abstract: The new life of a @entity0 being begins at the moment of fertilization, i.e. when an ovum and a sperm join together. From this moment on the fertilized egg has the capacity to achieve its complete development whether or not nidation takes place. Abortion means interruption of pregnancy through death of the fetus. Postcoital contraceptive agents are not contraceptive agents but abortifacient agents, since they intervene on an already fertilized egg. @entity2 have usually pathological reasons, as do early deliveries. The majority of the so called therapeutic abortions are really induced abortions disguised under another name; the cases in which a new pregnancy can really be detrimental to the mother are, these days, extremely rare, and @entity1 indications for abortion are mostly excuses to free a @entity0 from an unwanted pregnancy. Moreover, it is precisely the mothers who have sought an abortion who often become affected by serious psychological problems. Contraceptive agents must be distinguished according to their mechanism of action; those which are really anovulatory agents, and those which are antiimplantation agents, and, as such, abortifacient agents. The mechanism of action of @entity3 ( @entity4 ) does inhibit ovulation; at times, however, it inhibits implantation either by modifying tubal or uterine contractility, or by causing endometrial changes. In this case even @entity3 are abortifacient agents. The mechanism of action of all types of IUDs always leads to inhibition of nidation by modification of endometrial functions; as such, any IUD is an abortifacient agent. As international statistics can demonstrate the widespread use of contraception has not diminished the number of abortions; on the contrary the number has increased enormously. Obviously the step from contraception to abortion in case of contraception failure is a very short one.

title: [The rights of XXXX before birth].

answer: @entity0


abstract: BACKGROUND: @entity3 ( @entity3 ) with combined @entity9 / @entity1 and MYC rearrangement are rare and their clinical, cytogenetic and immunophenotypic features are not well characterized. Here, we describe a case of a 61-year-old @entity0 with @entity3 associated with these cytogenetic alterations and present a review of the literature of this disease. METHODS: Four-color flow cytometry (FC) was performed on a BD FACSCanto II flow cytometer. Data were analyzed with BD FACSDiva software. Cytogenetic, fluorescence in situ hybridization (FISH), and molecular studies were performed by conventional methods. A review of the literature was performed by a PubMed-assisted search. RESULTS: Including our case, eight B-LBLs associated with a documented "double-hit" karyotype ( @entity9 / @entity1 and 8q24/MYC rearrangement) were identified in the literature (male/female 2/6, age 15-65). Three occurred de-novo, and five had a history of a @entity8 + @entity5 . The typical immunophenotype was @entity8 , @entity4 , @entity10 positive, and negative for @entity7 and surface immunoglobulin (Ig), established either by flow cytometry or immunohistochemistry. Seven cases were @entity6 -, and one case was @entity6 +. Translocation partners of MYC varied, and included @entity9 , lambda light chain, and an unknown gene on chromosome 9. Prognosis was poor with median survival of five months. CONCLUSIONS: @entity0 with @entity3 associated with a combined @entity9 / @entity1 and MYC rearrangement often have a history of a mature @entity5 . The immunophenotype of these cases is different from that of mature "double-hit" @entity2 ; FC is essential to differentiate the @entity3 cases from the leukemic phase of mature @entity5 . This article is protected by copyright. All rights reserved.

title: Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined XXXX / @entity1 and MYC rearrangement.

answer: @entity9


abstract: BACKGROUND: @entity3 ( @entity3 ) with combined @entity9 / @entity1 and MYC rearrangement are rare and their clinical, cytogenetic and immunophenotypic features are not well characterized. Here, we describe a case of a 61-year-old @entity0 with @entity3 associated with these cytogenetic alterations and present a review of the literature of this disease. METHODS: Four-color flow cytometry (FC) was performed on a BD FACSCanto II flow cytometer. Data were analyzed with BD FACSDiva software. Cytogenetic, fluorescence in situ hybridization (FISH), and molecular studies were performed by conventional methods. A review of the literature was performed by a PubMed-assisted search. RESULTS: Including our case, eight B-LBLs associated with a documented "double-hit" karyotype ( @entity9 / @entity1 and 8q24/MYC rearrangement) were identified in the literature (male/female 2/6, age 15-65). Three occurred de-novo, and five had a history of a @entity8 + @entity5 . The typical immunophenotype was @entity8 , @entity4 , @entity10 positive, and negative for @entity7 and surface immunoglobulin (Ig), established either by flow cytometry or immunohistochemistry. Seven cases were @entity6 -, and one case was @entity6 +. Translocation partners of MYC varied, and included @entity9 , lambda light chain, and an unknown gene on chromosome 9. Prognosis was poor with median survival of five months. CONCLUSIONS: @entity0 with @entity3 associated with a combined @entity9 / @entity1 and MYC rearrangement often have a history of a mature @entity5 . The immunophenotype of these cases is different from that of mature "double-hit" @entity2 ; FC is essential to differentiate the @entity3 cases from the leukemic phase of mature @entity5 . This article is protected by copyright. All rights reserved.

title: Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined @entity9 / XXXX and MYC rearrangement.

answer: @entity1


abstract: INTRODUCTION: Robot-assisted minimally invasive esophagectomy with intra-thoracic @entity2 showed encouraging results but there is a lack of data to demonstrate the safety and feasibility. OBJECTIVE: The aim of this study is to report our experience in RA-ILE (robotic-assisted Ivor-Lewis esophagectomy) with robotic hand-sewn @entity2 . METHODS: This is a retrospective study of @entity0 who underwent robotic-assisted esophagectomy in prone position with intrathoracic @entity2 for @entity1 of the esophagus or esophago-gastric junction. RESULTS: From January 2012 to December 2014 we performed eight completely robot-assisted esophagectomy without @entity3 . The mortality rate at 30-day was zero. In two @entity0 we observed a partial leakage of the gastric tube that required revision. The mean operative time was 499        46   min including robotic set up and @entity0 positioning. The median hospital-stay was 10   days. Complete (R0) resection was accomplished in all @entity0 and the mean number of lymph nodes removed was 37.6        14 .7. CONCLUSIONS: This preliminary experience suggests that robotic-assisted RA-ILE for @entity1 is a real surgical option compared with conventional surgery with satisfactory results. Copyright    2015 John Wiley _ Sons, Ltd.

title: Robot-sewn Ivor-Lewis XXXX : preliminary experience and technical details.

answer: @entity2


abstract: UNASSIGNED: While chemotherapy is universally recognized as a frontline treatment strategy for @entity0 , it is not always successful; among the leading causes of treatment failure is existing and/or acquired multidrug resistance. @entity2 stem cells (CSCs), which constitute a minority of the cells of a @entity2 , are acknowledged to be responsible for increased resistance to chemo-drugs through a combination of increased expression of @entity6 -binding cassette transporters (ABC transporters), an increased anti-apoptotic defense, and/or the ability for extensive DNA repair like normal stem cells. Consequently, more effective therapy, especially targeted to CSCs, is urgently required. We studied the characteristics of 231-CSCs ( @entity7 +/ @entity10 -) sorted from @entity1 MDA-MB-231 @entity0 cells and demonstrated that 231-CSCs exhibited enhanced capacities for proliferation, migration, tumorigenesis and chemotherapy resistance. To address these multifunctional facets of CSCs, we devised a non-ionic surfactant-based vesicle (niosome) @entity3 to simultaneously deliver siRNAs, targeted to both the ABC transporter ( @entity9 ) and the anti-apoptosis defense gene ( @entity4 ), and @entity5 ( @entity8 ) to CSCs. The rationale is to sensitize CSCs to @entity8 by down regulating the drug-resistance gene @entity9 and simultaneously induce apoptosis by lowering @entity4 expression. The @entity3 ( @entity3 ) successfully delivered siRNAs and @entity8 to the cytoplasm and nuclei, respectively, and resulted in a down-regulation of @entity9 - and @entity4 mRNAs in CSCs by 60% and 65%, respectively, compared to the control. A corresponding decrease in protein expression was observed using Western blotting. The IC50 of @entity8 in CSCs concurrently decreased significantly. Our result established @entity3 as a promising multi-drug delivery platform for @entity2 treatment.

title: Enhanced efficacy of chemotherapy for XXXX stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense.

answer: @entity0


abstract: BACKGROUND: The @entity0 @entity2 ( @entity2 ) plays an important role in the pathogenesis of @entity3 ( @entity3 ). @entity3 is the leading cause of @entity4 worldwide. There is currently no effective treatment available. Preclinical studies in @entity3 @entity1 models are essential to develop new therapeutics. This requires further in-depth knowledge of the similarities and differences between @entity1 and @entity0 @entity2 . METHODS: We performed a microarray study to identify and functionally annotate @entity2 specific gene expression in @entity1 and @entity0 @entity2 . We used a meticulous method to determine C57BL/6J @entity1 @entity2 signature genes, correcting for possible RNA contamination from its adjacent layers: the choroid and the photoreceptors. We compared the signature genes, gene expression profiles and functional annotations of the @entity1 and @entity0 @entity2 . RESULTS: We defined sets of @entity1 (64), @entity0 (171) and @entity1 - @entity0 interspecies (22) @entity2 signature genes. Not unexpectedly, our gene expression analysis and comparative functional annotation suggested that, in general, the @entity1 and @entity0 @entity2 are very similar. For example, we found similarities for general features, like "organ development" and "disorders related to neurological tissue". However, detailed analysis of the molecular pathways and networks associated with @entity2 functions, suggested also multiple species-specific differences, some of which may be relevant for the development of @entity3 . For example, @entity5 , most likely the main complement regulator in @entity3 pathogenesis was highly expressed in @entity0 @entity2 , but almost absent in @entity1 @entity2 . Furthermore, functions assigned to @entity1 and @entity0 @entity2 expression profiles indicate (patho-) biological differences related to @entity3 , such as oxidative stress, Bruch's membrane, immune-regulation and outer blood retina barrier. CONCLUSION: These differences may be important for the development of new therapeutic strategies and translational studies in age-related @entity3 .

title: Comparison of @entity1 and @entity0 Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related XXXX .

answer: @entity3


abstract: BACKGROUND: The @entity0 @entity2 ( @entity2 ) plays an important role in the pathogenesis of @entity3 ( @entity3 ). @entity3 is the leading cause of @entity4 worldwide. There is currently no effective treatment available. Preclinical studies in @entity3 @entity1 models are essential to develop new therapeutics. This requires further in-depth knowledge of the similarities and differences between @entity1 and @entity0 @entity2 . METHODS: We performed a microarray study to identify and functionally annotate @entity2 specific gene expression in @entity1 and @entity0 @entity2 . We used a meticulous method to determine C57BL/6J @entity1 @entity2 signature genes, correcting for possible RNA contamination from its adjacent layers: the choroid and the photoreceptors. We compared the signature genes, gene expression profiles and functional annotations of the @entity1 and @entity0 @entity2 . RESULTS: We defined sets of @entity1 (64), @entity0 (171) and @entity1 - @entity0 interspecies (22) @entity2 signature genes. Not unexpectedly, our gene expression analysis and comparative functional annotation suggested that, in general, the @entity1 and @entity0 @entity2 are very similar. For example, we found similarities for general features, like "organ development" and "disorders related to neurological tissue". However, detailed analysis of the molecular pathways and networks associated with @entity2 functions, suggested also multiple species-specific differences, some of which may be relevant for the development of @entity3 . For example, @entity5 , most likely the main complement regulator in @entity3 pathogenesis was highly expressed in @entity0 @entity2 , but almost absent in @entity1 @entity2 . Furthermore, functions assigned to @entity1 and @entity0 @entity2 expression profiles indicate (patho-) biological differences related to @entity3 , such as oxidative stress, Bruch's membrane, immune-regulation and outer blood retina barrier. CONCLUSION: These differences may be important for the development of new therapeutic strategies and translational studies in age-related @entity3 .

title: Comparison of XXXX and @entity0 Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related @entity3 .

answer: @entity1


abstract: BACKGROUND: The @entity0 @entity2 ( @entity2 ) plays an important role in the pathogenesis of @entity3 ( @entity3 ). @entity3 is the leading cause of @entity4 worldwide. There is currently no effective treatment available. Preclinical studies in @entity3 @entity1 models are essential to develop new therapeutics. This requires further in-depth knowledge of the similarities and differences between @entity1 and @entity0 @entity2 . METHODS: We performed a microarray study to identify and functionally annotate @entity2 specific gene expression in @entity1 and @entity0 @entity2 . We used a meticulous method to determine C57BL/6J @entity1 @entity2 signature genes, correcting for possible RNA contamination from its adjacent layers: the choroid and the photoreceptors. We compared the signature genes, gene expression profiles and functional annotations of the @entity1 and @entity0 @entity2 . RESULTS: We defined sets of @entity1 (64), @entity0 (171) and @entity1 - @entity0 interspecies (22) @entity2 signature genes. Not unexpectedly, our gene expression analysis and comparative functional annotation suggested that, in general, the @entity1 and @entity0 @entity2 are very similar. For example, we found similarities for general features, like "organ development" and "disorders related to neurological tissue". However, detailed analysis of the molecular pathways and networks associated with @entity2 functions, suggested also multiple species-specific differences, some of which may be relevant for the development of @entity3 . For example, @entity5 , most likely the main complement regulator in @entity3 pathogenesis was highly expressed in @entity0 @entity2 , but almost absent in @entity1 @entity2 . Furthermore, functions assigned to @entity1 and @entity0 @entity2 expression profiles indicate (patho-) biological differences related to @entity3 , such as oxidative stress, Bruch's membrane, immune-regulation and outer blood retina barrier. CONCLUSION: These differences may be important for the development of new therapeutic strategies and translational studies in age-related @entity3 .

title: Comparison of @entity1 and XXXX Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related @entity3 .

answer: @entity0


abstract: UNASSIGNED: Despite major advances in understanding the molecular and genetic basis of @entity3 , @entity2 remains the cause of >90% of @entity3 -related mortality. Understanding @entity2 initiation and progression is critical to developing new therapeutic strategies to treat and prevent @entity2 . Prevailing theories hypothesize that @entity2 are seeded by rare @entity3 cells with unique properties, which may function like stem cells in their ability to initiate and propagate @entity3 . However, the identity of @entity2 -initiating cells in @entity1 @entity0 remains elusive, and whether @entity2 are hierarchically organized is unknown. Here we show at the single-cell level that early stage metastatic cells possess a distinct stem-like gene expression signature. To identify and isolate metastatic cells from @entity1 -derived xenograft models of @entity1 @entity0 , we developed a highly sensitive fluorescence-activated cell sorting (FACS)-based assay, which allowed us to enumerate metastatic cells in @entity4 peripheral tissues. We compared gene signatures in metastatic cells from tissues with low versus high metastatic burden. Metastatic cells from low-burden tissues were distinct owing to their increased expression of stem cell, epithelial-to-mesenchymal transition, pro-survival, and dormancy-associated genes. By contrast, metastatic cells from high-burden tissues were similar to primary @entity3 cells, which were more heterogeneous and expressed higher levels of luminal differentiation genes. Transplantation of stem-like metastatic cells from low-burden tissues showed that they have considerable @entity3 -initiating capacity, and can differentiate to produce luminal-like @entity3 cells. Progression to high metastatic burden was associated with increased proliferation and MYC expression, which could be attenuated by treatment with cyclin-dependent kinase (CDK) inhibitors. These findings support a hierarchical model for @entity2 , in which @entity2 are initiated by stem-like cells that proliferate and differentiate to produce advanced @entity2 .

title: Single-cell analysis reveals a stem-cell program in @entity1 metastatic XXXX cells.

answer: @entity0


abstract: UNASSIGNED: Despite major advances in understanding the molecular and genetic basis of @entity3 , @entity2 remains the cause of >90% of @entity3 -related mortality. Understanding @entity2 initiation and progression is critical to developing new therapeutic strategies to treat and prevent @entity2 . Prevailing theories hypothesize that @entity2 are seeded by rare @entity3 cells with unique properties, which may function like stem cells in their ability to initiate and propagate @entity3 . However, the identity of @entity2 -initiating cells in @entity1 @entity0 remains elusive, and whether @entity2 are hierarchically organized is unknown. Here we show at the single-cell level that early stage metastatic cells possess a distinct stem-like gene expression signature. To identify and isolate metastatic cells from @entity1 -derived xenograft models of @entity1 @entity0 , we developed a highly sensitive fluorescence-activated cell sorting (FACS)-based assay, which allowed us to enumerate metastatic cells in @entity4 peripheral tissues. We compared gene signatures in metastatic cells from tissues with low versus high metastatic burden. Metastatic cells from low-burden tissues were distinct owing to their increased expression of stem cell, epithelial-to-mesenchymal transition, pro-survival, and dormancy-associated genes. By contrast, metastatic cells from high-burden tissues were similar to primary @entity3 cells, which were more heterogeneous and expressed higher levels of luminal differentiation genes. Transplantation of stem-like metastatic cells from low-burden tissues showed that they have considerable @entity3 -initiating capacity, and can differentiate to produce luminal-like @entity3 cells. Progression to high metastatic burden was associated with increased proliferation and MYC expression, which could be attenuated by treatment with cyclin-dependent kinase (CDK) inhibitors. These findings support a hierarchical model for @entity2 , in which @entity2 are initiated by stem-like cells that proliferate and differentiate to produce advanced @entity2 .

title: Single-cell analysis reveals a stem-cell program in XXXX metastatic @entity0 cells.

answer: @entity1


abstract: OBJECTIVES: To compare the efficacy of two exercise programmes in reducing @entity1 for individuals with non-specific @entity2 and to examine the underlying mechanical factors related to @entity1 for individuals with NSLBP. DESIGN: A single-blind, randomized controlled trial. METHODS: Eighty @entity0 were recruited from eleven community-based general medical practices and randomized into two groups completing either a lumbopelvic motor control or a combined lumbopelvic motor control and progressive hip strengthening exercise therapy programme. All @entity0 received an education session, 6 rehabilitation sessions including real time ultrasound training, and a home based exercise programme manual and log book. The primary outcomes were @entity1 (0-100mm visual analogue scale), and disability (Oswestry Disability Index V2). The secondary outcomes were hip strength (N/kg) and two-dimensional frontal plane biomechanics (  ) measure during the static Trendelenburg test and while walking. All outcomes were measured at baseline and at 6-week follow up. RESULTS: There was no statistical difference in the change in @entity1 (x  =-4.0mm, t=-1.07, p=0.29, 95%CI -11.5, 3.5) or disability (x  =-0.3%, t=-0.19, p=0.85, 95%CI -3.5, 2.8) between groups. Within group comparisons revealed clinically meaningful reductions in @entity1 for both Group One (x  =-20.9mm, 95%CI -25.7, -16.1) and Group Two (x  =-24.9, 95%CI -30.8, -19.0). CONCLUSIONS: Both exercise programmes had similar efficacy in reducing @entity1 . The addition of hip strengthening exercises to a motor control exercise programme does not appear to result in improved clinical outcome for @entity1 for individuals with non-specific @entity2 .

title: The effect of the addition of hip strengthening exercises to a lumbopelvic exercise programme for the treatment of non-specific XXXX : A randomized controlled trial.

answer: @entity2


abstract: AIMS: @entity11 independently predicts @entity3 and @entity6 . We examined the @entity9 ( @entity9 , defined as an estimated GFR <  60  ml/min/1.73  m(2) ) and quality of care in a cross-sectional survey of adults (age >=   18  years) with @entity4  2 @entity1 across Asia. METHODS: The Joint Asia @entity1 Evaluation programme is a disease-management programme implemented using an electronic portal that systematically captures clinical characteristics of all @entity0 enrolled. Between July 2007 and December 2012, data on 28  110 consecutively enrolled @entity0 (China: 3415, Hong Kong: 15  196, India: 3714, Korea: 1651, Philippines: 3364, Vietnam: 692, Taiwan: 78) were analysed. RESULTS: In this survey, 15.9% of @entity0 had @entity9 , 25.0% had microalbuminuria and 12.5% had macroalbuminuria. @entity0 with @entity9 were less likely to achieve HbA1c   <  53  mmol/mol (7.0%) (36.0% vs. 42.3%) and blood pressure <  130/80  mmHg (20.8% vs. 35.3%), and were more likely to have @entity10 (26.2% vs. 8.7%), @entity2 (29.0% vs. 7.7%), @entity3 (26.6% vs. 8.7%) and self-reported hypoglycaemia (18.9% vs. 8.2%). Despite high frequencies of @entity8 (74.8%) and dyslipidaemia (93.0%) among @entity9 @entity0 , only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins. On logistic regression, old age, male gender, @entity7 use, long disease duration, high HbA1c , blood pressure and BMI, and low LDL @entity5 were independently associated with @entity9 (all P  <  0.05). CONCLUSIONS: The poor control of risk factors, suboptimal use of organ-protective drugs and high frequencies of hypoglycaemia highlight major treatment gaps in @entity0 with @entity11 in Asia. This article is protected by copyright. All rights reserved.

title: Quality of care in @entity0 with @entity11 in Asia: The Joint Asia XXXX Evaluation (JADE) Registry.

answer: @entity1


abstract: AIMS: @entity11 independently predicts @entity3 and @entity6 . We examined the @entity9 ( @entity9 , defined as an estimated GFR <  60  ml/min/1.73  m(2) ) and quality of care in a cross-sectional survey of adults (age >=   18  years) with @entity4  2 @entity1 across Asia. METHODS: The Joint Asia @entity1 Evaluation programme is a disease-management programme implemented using an electronic portal that systematically captures clinical characteristics of all @entity0 enrolled. Between July 2007 and December 2012, data on 28  110 consecutively enrolled @entity0 (China: 3415, Hong Kong: 15  196, India: 3714, Korea: 1651, Philippines: 3364, Vietnam: 692, Taiwan: 78) were analysed. RESULTS: In this survey, 15.9% of @entity0 had @entity9 , 25.0% had microalbuminuria and 12.5% had macroalbuminuria. @entity0 with @entity9 were less likely to achieve HbA1c   <  53  mmol/mol (7.0%) (36.0% vs. 42.3%) and blood pressure <  130/80  mmHg (20.8% vs. 35.3%), and were more likely to have @entity10 (26.2% vs. 8.7%), @entity2 (29.0% vs. 7.7%), @entity3 (26.6% vs. 8.7%) and self-reported hypoglycaemia (18.9% vs. 8.2%). Despite high frequencies of @entity8 (74.8%) and dyslipidaemia (93.0%) among @entity9 @entity0 , only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins. On logistic regression, old age, male gender, @entity7 use, long disease duration, high HbA1c , blood pressure and BMI, and low LDL @entity5 were independently associated with @entity9 (all P  <  0.05). CONCLUSIONS: The poor control of risk factors, suboptimal use of organ-protective drugs and high frequencies of hypoglycaemia highlight major treatment gaps in @entity0 with @entity11 in Asia. This article is protected by copyright. All rights reserved.

title: Quality of care in @entity0 with XXXX in Asia: The Joint Asia @entity1 Evaluation (JADE) Registry.

answer: @entity11


abstract: AIMS: @entity11 independently predicts @entity3 and @entity6 . We examined the @entity9 ( @entity9 , defined as an estimated GFR <  60  ml/min/1.73  m(2) ) and quality of care in a cross-sectional survey of adults (age >=   18  years) with @entity4  2 @entity1 across Asia. METHODS: The Joint Asia @entity1 Evaluation programme is a disease-management programme implemented using an electronic portal that systematically captures clinical characteristics of all @entity0 enrolled. Between July 2007 and December 2012, data on 28  110 consecutively enrolled @entity0 (China: 3415, Hong Kong: 15  196, India: 3714, Korea: 1651, Philippines: 3364, Vietnam: 692, Taiwan: 78) were analysed. RESULTS: In this survey, 15.9% of @entity0 had @entity9 , 25.0% had microalbuminuria and 12.5% had macroalbuminuria. @entity0 with @entity9 were less likely to achieve HbA1c   <  53  mmol/mol (7.0%) (36.0% vs. 42.3%) and blood pressure <  130/80  mmHg (20.8% vs. 35.3%), and were more likely to have @entity10 (26.2% vs. 8.7%), @entity2 (29.0% vs. 7.7%), @entity3 (26.6% vs. 8.7%) and self-reported hypoglycaemia (18.9% vs. 8.2%). Despite high frequencies of @entity8 (74.8%) and dyslipidaemia (93.0%) among @entity9 @entity0 , only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins. On logistic regression, old age, male gender, @entity7 use, long disease duration, high HbA1c , blood pressure and BMI, and low LDL @entity5 were independently associated with @entity9 (all P  <  0.05). CONCLUSIONS: The poor control of risk factors, suboptimal use of organ-protective drugs and high frequencies of hypoglycaemia highlight major treatment gaps in @entity0 with @entity11 in Asia. This article is protected by copyright. All rights reserved.

title: Quality of care in XXXX with @entity11 in Asia: The Joint Asia @entity1 Evaluation (JADE) Registry.

answer: @entity0


abstract: BACKGROUND: The study meant to define the prognostic factors that help in prescribing intrauterine insemination (IUI) for @entity2 treatment which remains an area of continuous improvements. METHODS: The diagnostic indications of a cohort of IUI-treated @entity0 and their corresponding pregnancy rates (PRs) were randomly and prospectively studied among Saudi cohort of 303 @entity0 for a period of 20 months. The indications of IUI cases were statistically analyzed for those eligible @entity0 over a period of twenty months (January 2010 till August 2011), and the PR that corresponded to each group was investigated as well. P-value less than 0.05 was considered significant. RESULTS: The highest PR, 18.87%, of the @entity4 ( @entity4 )-only diagnosed @entity0 , was significantly higher than the average PR of all other indications combined, 7.22%, (p = 0.011, compared to all other groups combined). The second highest PR, 14.0%, of the @entity6 ( @entity6 )-only indication, was double the PR average of all other indications combined, though it did not reach significance. However, @entity4 and @entity6 accompanied by other indications caused the PR to drop to 5.88% and 5.56%, respectively. However, a group of some hormonal-imbalance based indications had the least PR (0.0% to 2.70%). Those indications were elevated serum FSH, @entity5 , hypogonadotrophy, @entity3 and @entity1 . The rest of the indications had an average PR (8.33% to 11.11%). CONCLUSION: There is a reasonable chance of conception after IUI treatment for female factor @entity2 except in cases with sever hormonal imbalance. The @entity4 cases having the best success chances.

title: Accurate diagnosis as a prognostic factor in intrauterine insemination treatment of XXXX saudi @entity0 .

answer: @entity2


abstract: BACKGROUND: The study meant to define the prognostic factors that help in prescribing intrauterine insemination (IUI) for @entity2 treatment which remains an area of continuous improvements. METHODS: The diagnostic indications of a cohort of IUI-treated @entity0 and their corresponding pregnancy rates (PRs) were randomly and prospectively studied among Saudi cohort of 303 @entity0 for a period of 20 months. The indications of IUI cases were statistically analyzed for those eligible @entity0 over a period of twenty months (January 2010 till August 2011), and the PR that corresponded to each group was investigated as well. P-value less than 0.05 was considered significant. RESULTS: The highest PR, 18.87%, of the @entity4 ( @entity4 )-only diagnosed @entity0 , was significantly higher than the average PR of all other indications combined, 7.22%, (p = 0.011, compared to all other groups combined). The second highest PR, 14.0%, of the @entity6 ( @entity6 )-only indication, was double the PR average of all other indications combined, though it did not reach significance. However, @entity4 and @entity6 accompanied by other indications caused the PR to drop to 5.88% and 5.56%, respectively. However, a group of some hormonal-imbalance based indications had the least PR (0.0% to 2.70%). Those indications were elevated serum FSH, @entity5 , hypogonadotrophy, @entity3 and @entity1 . The rest of the indications had an average PR (8.33% to 11.11%). CONCLUSION: There is a reasonable chance of conception after IUI treatment for female factor @entity2 except in cases with sever hormonal imbalance. The @entity4 cases having the best success chances.

title: Accurate diagnosis as a prognostic factor in intrauterine insemination treatment of @entity2 saudi XXXX .

answer: @entity0


abstract: BACKGROUND: Endothelial injuries regularly occur in @entity4 and during interventional therapies of the @entity2 . Disturbances in the endothelial integrity can lead to insufficient blood supply and bear the risk of @entity3 formation and acute @entity2 . At present, effective therapeutics to restore endothelial integrity are barely available. We analyzed the effect of pharmacological @entity11 -inhibition by @entity10 on endogenous progenitor cell-based endothelial regeneration via the SDF-1a/ @entity8 -axis after acute endothelial damage in a @entity0 model of @entity1 . METHODS AND RESULTS: Induction of a defined endothelial injury was performed in the carotid artery of C57Bl/6 @entity0 which led to a local upregulation of SDF-1a expression. Animals were treated with placebo, @entity10 or @entity10 + @entity7 . Using mass spectrometry we could prove that @entity10 prevented cleavage of the chemokine SDF-1a. Accordingly, increased SDF-1a concentrations enhanced recruitment of systemically applied and endogenous circulating @entity8 + progenitor cells to the site of @entity5 followed by a significantly accelerated reendothelialization as compared to placebo-treated animals. Improved endothelial recovery, as well as recruitment of circulating @entity8 + progenitor cells (CD133+, @entity9 +), was reversed by @entity8 -antagonization through @entity7 . In addition, short-term @entity10 treatment did not significantly promote @entity6 . CONCLUSION: @entity10 can accelerate endothelial regeneration after acute endothelial injury. @entity11 inhibitors prevent degradation of the chemokine SDF-1a and thus improve the recruitment of regenerative circulating @entity8 + progenitor cells which mediate local endothelial cell proliferation without adversely affecting vessel wall architecture.

title: Short-term inhibition of XXXX enhances endothelial regeneration after acute @entity5 via enhanced recruitment of circulating progenitor cells.

answer: @entity11


abstract: BACKGROUND: Endothelial injuries regularly occur in @entity4 and during interventional therapies of the @entity2 . Disturbances in the endothelial integrity can lead to insufficient blood supply and bear the risk of @entity3 formation and acute @entity2 . At present, effective therapeutics to restore endothelial integrity are barely available. We analyzed the effect of pharmacological @entity11 -inhibition by @entity10 on endogenous progenitor cell-based endothelial regeneration via the SDF-1a/ @entity8 -axis after acute endothelial damage in a @entity0 model of @entity1 . METHODS AND RESULTS: Induction of a defined endothelial injury was performed in the carotid artery of C57Bl/6 @entity0 which led to a local upregulation of SDF-1a expression. Animals were treated with placebo, @entity10 or @entity10 + @entity7 . Using mass spectrometry we could prove that @entity10 prevented cleavage of the chemokine SDF-1a. Accordingly, increased SDF-1a concentrations enhanced recruitment of systemically applied and endogenous circulating @entity8 + progenitor cells to the site of @entity5 followed by a significantly accelerated reendothelialization as compared to placebo-treated animals. Improved endothelial recovery, as well as recruitment of circulating @entity8 + progenitor cells (CD133+, @entity9 +), was reversed by @entity8 -antagonization through @entity7 . In addition, short-term @entity10 treatment did not significantly promote @entity6 . CONCLUSION: @entity10 can accelerate endothelial regeneration after acute endothelial injury. @entity11 inhibitors prevent degradation of the chemokine SDF-1a and thus improve the recruitment of regenerative circulating @entity8 + progenitor cells which mediate local endothelial cell proliferation without adversely affecting vessel wall architecture.

title: Short-term inhibition of @entity11 enhances endothelial regeneration after acute XXXX via enhanced recruitment of circulating progenitor cells.

answer: @entity5


abstract: BACKGROUND: @entity2 ( @entity2 ) is characterized by the accumulation of b-amyloid (Ab) associated with @entity3 and @entity0 . The functional form to model the association between Ab and regional @entity3 has not been well defined. To determine the relationship between Ab and @entity1 , we compared the performance of the usual dichotomization of cerebrospinal fluid (CSF) Ab to identify subjects as Ab+ and Ab- with a trilinear spline model of CSF Ab. METHODS: One hundred and eighty-three subjects with mild @entity0 and 108 cognitively normal controls with baseline CSF Ab and up to 4  years of longitudinal magnetic resonance imaging data from the @entity2 Neuroimaging Initiative were analyzed using mixed-effects regression. Piecewise-linear splines were used to evaluate the nonlinear nature of the association between CSF Ab and regional @entity1 and to identify points of acceleration of @entity1 with respect to Ab. Several parameterizations of CSF Ab were compared using likelihood ratio tests and the Akaike information criterion. Periods of acceleration of @entity1 in which subjects transition from CSF Ab negativity to CSF Ab positivity were estimated from the spline models and tested for significance. RESULTS: Spline models resulted in better fits for many temporal and parietal regions compared with the dichotomous models. The trilinear model showed that periods of acceleration of @entity1 varied greatly by region with early changes seen in the insula, amygdala, precuneus, hippocampus, and other temporal regions, occurring before the clinical threshold for CSF Ab positivity. CONCLUSION: The use of piecewise-linear splines provides an improved model of the nonlinear association between CSF Ab and regional @entity1 in regions implicated in the progression of @entity2 . The important biological finding of this work is that some brain regions show periods of accelerated volume loss well before the CSF Ab42 threshold. This implies that signs of @entity3 develop before the current conventional definition of "preclinical @entity2 ".

title: The transitional association between b-amyloid pathology and regional XXXX .

answer: @entity3


abstract: UNASSIGNED: BackgroundDespite the expanding worldwide distribution of @entity0 and its increasing relevance as arboviral vector, current methods to collect adult specimens are not optimal. Improved approaches are thus needed to monitor their density and pathogen infections, and to establish baseline data for control interventions. A widely used device is the BG-Sentinel (BG-trap) which mostly targets host-seeking females attracted by release of @entity4 and/or a synthetic odour blend (the BG lure). We compared the attractiveness of this blend to that of the Mbita ( @entity5 ) lure, a new synthetic blend of proven efficiency in attracting @entity2 vectors, and evaluated the additional effect of @entity4 to the two odour baits.FindingsWe carried out 6x6 Latin square experiments in two Ae. @entity1 areas in Rome, baiting the BG-traps as follows: @entity4 , BG lure, @entity5 lure, BG lure  +  @entity4 , @entity5 lure  +  @entity4 , no bait. @entity4 was derived from @entity3 -fermented sugar. Overall, 949 females and 816 males were collected. Baited traps collected significantly more females than unbaited ones. Traps baited with either lures in combination with @entity4 were more effective than those baited with @entity4 alone. No significant differences were observed in female captures between traps baited with any of the two lures, nor between the two lures, independently from the addition of @entity4 . The use of BG lure  +  @entity4 significantly increased males catches compared to unbaited traps.ConclusionsThe results suggest a broad significance of the @entity5 lure for sampling medically important mosquito species and highlight the high efficacy of the combination of lures  +  @entity4 for female Ae. albopictus and of BG lure  +  @entity4 for males, leading to consider @entity4 as an essential additional cue for the sampling of this species.

title: Field evaluation of a novel synthetic odour blend and of the synergistic role of carbon dioxide for sampling host-seeking XXXX adults in Rome, Italy.

answer: @entity0


abstract: OBJECTIVE: To assess if a 12-week exercise intervention to improve aerobic fitness, muscle strength, and core stability also had an impact on @entity3 , @entity2 , activity, and participation in adults with @entity4 , an @entity1 . DESIGN: Open-label trial. Change was assessed by the chi-square test and Wilcoxon signed-rank test. SETTING: Physiotherapy practices. @entity0 : Mildly affected adult @entity0 with @entity4 who were not dependent on ventilators and/or walking devices and were receiving enzyme replacement therapy. INTERVENTION: @entity0 participated in a 12-week exercise program, which included 36 sessions of standardized aerobic, resistance, and core stability exercises. MAIN OUTCOME MEASURES: Before and after the training program we evaluated @entity3 (Fatigue Severity Scale), @entity2 (yes/no), motor function (Quantitative Muscle Function Test, Rasch-built Pompe-specific Activity Scale), amount of physical activity (activity monitor), and health status (Medical Outcomes Study 36-Item Short-Form Health Survey). RESULTS: Of the 25 @entity0 enrolled, 23 completed the program. At the end of the program, levels of @entity3 (median, 5.33 to 4.78, P=.01) and @entity2 (56.5% to 21.7%, P=.04) improved. The quality of motor function and the amount of physical activity @entity0 engaged in did not change. Changes in @entity2 and @entity3 were not related to improvements in aerobic fitness or muscle strength. CONCLUSIONS: This study in mildly affected adult @entity0 with @entity4 suggests that a combined training program aiming to increase aerobic fitness, muscle strength, and core stability also leads to improvements in @entity3 and @entity2 .

title: Exercise training in adults with @entity4 : the effects on @entity2 , XXXX , and functioning.

answer: @entity3


abstract: OBJECTIVE: To assess if a 12-week exercise intervention to improve aerobic fitness, muscle strength, and core stability also had an impact on @entity3 , @entity2 , activity, and participation in adults with @entity4 , an @entity1 . DESIGN: Open-label trial. Change was assessed by the chi-square test and Wilcoxon signed-rank test. SETTING: Physiotherapy practices. @entity0 : Mildly affected adult @entity0 with @entity4 who were not dependent on ventilators and/or walking devices and were receiving enzyme replacement therapy. INTERVENTION: @entity0 participated in a 12-week exercise program, which included 36 sessions of standardized aerobic, resistance, and core stability exercises. MAIN OUTCOME MEASURES: Before and after the training program we evaluated @entity3 (Fatigue Severity Scale), @entity2 (yes/no), motor function (Quantitative Muscle Function Test, Rasch-built Pompe-specific Activity Scale), amount of physical activity (activity monitor), and health status (Medical Outcomes Study 36-Item Short-Form Health Survey). RESULTS: Of the 25 @entity0 enrolled, 23 completed the program. At the end of the program, levels of @entity3 (median, 5.33 to 4.78, P=.01) and @entity2 (56.5% to 21.7%, P=.04) improved. The quality of motor function and the amount of physical activity @entity0 engaged in did not change. Changes in @entity2 and @entity3 were not related to improvements in aerobic fitness or muscle strength. CONCLUSIONS: This study in mildly affected adult @entity0 with @entity4 suggests that a combined training program aiming to increase aerobic fitness, muscle strength, and core stability also leads to improvements in @entity3 and @entity2 .

title: Exercise training in adults with @entity4 : the effects on XXXX , @entity3 , and functioning.

answer: @entity2


abstract: OBJECTIVE: To assess if a 12-week exercise intervention to improve aerobic fitness, muscle strength, and core stability also had an impact on @entity3 , @entity2 , activity, and participation in adults with @entity4 , an @entity1 . DESIGN: Open-label trial. Change was assessed by the chi-square test and Wilcoxon signed-rank test. SETTING: Physiotherapy practices. @entity0 : Mildly affected adult @entity0 with @entity4 who were not dependent on ventilators and/or walking devices and were receiving enzyme replacement therapy. INTERVENTION: @entity0 participated in a 12-week exercise program, which included 36 sessions of standardized aerobic, resistance, and core stability exercises. MAIN OUTCOME MEASURES: Before and after the training program we evaluated @entity3 (Fatigue Severity Scale), @entity2 (yes/no), motor function (Quantitative Muscle Function Test, Rasch-built Pompe-specific Activity Scale), amount of physical activity (activity monitor), and health status (Medical Outcomes Study 36-Item Short-Form Health Survey). RESULTS: Of the 25 @entity0 enrolled, 23 completed the program. At the end of the program, levels of @entity3 (median, 5.33 to 4.78, P=.01) and @entity2 (56.5% to 21.7%, P=.04) improved. The quality of motor function and the amount of physical activity @entity0 engaged in did not change. Changes in @entity2 and @entity3 were not related to improvements in aerobic fitness or muscle strength. CONCLUSIONS: This study in mildly affected adult @entity0 with @entity4 suggests that a combined training program aiming to increase aerobic fitness, muscle strength, and core stability also leads to improvements in @entity3 and @entity2 .

title: Exercise training in adults with XXXX : the effects on @entity2 , @entity3 , and functioning.

answer: @entity4


abstract: BACKGROUND: @entity2 is a major, complicated disease in @entity0 with @entity5 . However, the influence of @entity2 on the prognosis of @entity0 with varying types of @entity5 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity0 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity0 with subtypes of @entity5 , specifically @entity3 ( @entity3 ), @entity7 ( @entity7 ), or @entity6 ( @entity6 ), were neuropathologically diagnosed and examined. @entity2 incidence, cause of @entity4 , and the clinical time-course of @entity5 were compared among the @entity5 subtypes. The time to @entity4 from @entity5 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity5 with or without @entity2 . Risk factors for survival time on all study @entity0 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity0 , 63 (40.1%) had @entity3 , 42 (26.8%) had @entity7 , and 52 (33.1%) had @entity6 . @entity2 complication was observed with high incidence in each subtype of @entity5 , especially in @entity7 (90.5%). The median total duration from @entity5 onset to @entity4 was 8 years in @entity3 and @entity7 , and 5 years in @entity6 . The @entity6 subtype had more male @entity0 than @entity3 or @entity7 (P = 0.010), and age of @entity4 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity2 (P = 0.002). The factors associated with shorter survival time were male gender, @entity2 , @entity1 , age of @entity5 onset   >=    75   years, and @entity6 . CONCLUSIONS: @entity2 complications shortened the survival time of @entity0 with @entity3 , @entity7 , and @entity6 .

title: Influence of @entity2 on the prognosis of @entity0 with autopsy-confirmed XXXX , @entity7 , and @entity6 .

answer: @entity3


abstract: BACKGROUND: @entity2 is a major, complicated disease in @entity0 with @entity5 . However, the influence of @entity2 on the prognosis of @entity0 with varying types of @entity5 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity0 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity0 with subtypes of @entity5 , specifically @entity3 ( @entity3 ), @entity7 ( @entity7 ), or @entity6 ( @entity6 ), were neuropathologically diagnosed and examined. @entity2 incidence, cause of @entity4 , and the clinical time-course of @entity5 were compared among the @entity5 subtypes. The time to @entity4 from @entity5 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity5 with or without @entity2 . Risk factors for survival time on all study @entity0 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity0 , 63 (40.1%) had @entity3 , 42 (26.8%) had @entity7 , and 52 (33.1%) had @entity6 . @entity2 complication was observed with high incidence in each subtype of @entity5 , especially in @entity7 (90.5%). The median total duration from @entity5 onset to @entity4 was 8 years in @entity3 and @entity7 , and 5 years in @entity6 . The @entity6 subtype had more male @entity0 than @entity3 or @entity7 (P = 0.010), and age of @entity4 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity2 (P = 0.002). The factors associated with shorter survival time were male gender, @entity2 , @entity1 , age of @entity5 onset   >=    75   years, and @entity6 . CONCLUSIONS: @entity2 complications shortened the survival time of @entity0 with @entity3 , @entity7 , and @entity6 .

title: Influence of @entity2 on the prognosis of @entity0 with autopsy-confirmed @entity3 , @entity7 , and XXXX .

answer: @entity6


abstract: BACKGROUND: @entity2 is a major, complicated disease in @entity0 with @entity5 . However, the influence of @entity2 on the prognosis of @entity0 with varying types of @entity5 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity0 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity0 with subtypes of @entity5 , specifically @entity3 ( @entity3 ), @entity7 ( @entity7 ), or @entity6 ( @entity6 ), were neuropathologically diagnosed and examined. @entity2 incidence, cause of @entity4 , and the clinical time-course of @entity5 were compared among the @entity5 subtypes. The time to @entity4 from @entity5 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity5 with or without @entity2 . Risk factors for survival time on all study @entity0 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity0 , 63 (40.1%) had @entity3 , 42 (26.8%) had @entity7 , and 52 (33.1%) had @entity6 . @entity2 complication was observed with high incidence in each subtype of @entity5 , especially in @entity7 (90.5%). The median total duration from @entity5 onset to @entity4 was 8 years in @entity3 and @entity7 , and 5 years in @entity6 . The @entity6 subtype had more male @entity0 than @entity3 or @entity7 (P = 0.010), and age of @entity4 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity2 (P = 0.002). The factors associated with shorter survival time were male gender, @entity2 , @entity1 , age of @entity5 onset   >=    75   years, and @entity6 . CONCLUSIONS: @entity2 complications shortened the survival time of @entity0 with @entity3 , @entity7 , and @entity6 .

title: Influence of XXXX on the prognosis of @entity0 with autopsy-confirmed @entity3 , @entity7 , and @entity6 .

answer: @entity2


abstract: BACKGROUND: @entity2 is a major, complicated disease in @entity0 with @entity5 . However, the influence of @entity2 on the prognosis of @entity0 with varying types of @entity5 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity0 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity0 with subtypes of @entity5 , specifically @entity3 ( @entity3 ), @entity7 ( @entity7 ), or @entity6 ( @entity6 ), were neuropathologically diagnosed and examined. @entity2 incidence, cause of @entity4 , and the clinical time-course of @entity5 were compared among the @entity5 subtypes. The time to @entity4 from @entity5 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity5 with or without @entity2 . Risk factors for survival time on all study @entity0 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity0 , 63 (40.1%) had @entity3 , 42 (26.8%) had @entity7 , and 52 (33.1%) had @entity6 . @entity2 complication was observed with high incidence in each subtype of @entity5 , especially in @entity7 (90.5%). The median total duration from @entity5 onset to @entity4 was 8 years in @entity3 and @entity7 , and 5 years in @entity6 . The @entity6 subtype had more male @entity0 than @entity3 or @entity7 (P = 0.010), and age of @entity4 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity2 (P = 0.002). The factors associated with shorter survival time were male gender, @entity2 , @entity1 , age of @entity5 onset   >=    75   years, and @entity6 . CONCLUSIONS: @entity2 complications shortened the survival time of @entity0 with @entity3 , @entity7 , and @entity6 .

title: Influence of @entity2 on the prognosis of @entity0 with autopsy-confirmed @entity3 , XXXX , and @entity6 .

answer: @entity7


abstract: BACKGROUND: @entity2 is a major, complicated disease in @entity0 with @entity5 . However, the influence of @entity2 on the prognosis of @entity0 with varying types of @entity5 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity0 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity0 with subtypes of @entity5 , specifically @entity3 ( @entity3 ), @entity7 ( @entity7 ), or @entity6 ( @entity6 ), were neuropathologically diagnosed and examined. @entity2 incidence, cause of @entity4 , and the clinical time-course of @entity5 were compared among the @entity5 subtypes. The time to @entity4 from @entity5 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity5 with or without @entity2 . Risk factors for survival time on all study @entity0 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity0 , 63 (40.1%) had @entity3 , 42 (26.8%) had @entity7 , and 52 (33.1%) had @entity6 . @entity2 complication was observed with high incidence in each subtype of @entity5 , especially in @entity7 (90.5%). The median total duration from @entity5 onset to @entity4 was 8 years in @entity3 and @entity7 , and 5 years in @entity6 . The @entity6 subtype had more male @entity0 than @entity3 or @entity7 (P = 0.010), and age of @entity4 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity2 (P = 0.002). The factors associated with shorter survival time were male gender, @entity2 , @entity1 , age of @entity5 onset   >=    75   years, and @entity6 . CONCLUSIONS: @entity2 complications shortened the survival time of @entity0 with @entity3 , @entity7 , and @entity6 .

title: Influence of @entity2 on the prognosis of XXXX with autopsy-confirmed @entity3 , @entity7 , and @entity6 .

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: It is crucial to decrease @entity1 during functional endoscopic sinus surgery. Our primary goal was to investigate the effects of magnesium sulfate and dexmedetomidine used for controlled @entity2 on the visibility of the surgical site. METHODS: 60 @entity0 aged between 18 and 65 years were enrolled. In the magnesium sulfate group (Group M), @entity0 were administered 40mg/kg magnesium sulfate in 100mL saline solution over 10min as the intravenous loading dose 10min before induction, with a subsequent 10-15 g/kg/h infusion during surgery. In the dexmedetomidine group (Group D), @entity0 were administered 1 g/kg dexmedetomidine in 100mL saline solution as the loading dose 10min before surgery and 0.5-1 g/kg/h dexmedetomidine during surgery. Deliberate @entity2 was defined as a mean arterial pressure of 60-70mmHg. RESULTS: Bleeding score was significantly decreased in Group D (p=0.002). Mean arterial pressure values were significantly decreased in Group D compared to that in Group M, except for the initial stage, after induction and 5min after intubation (p<0.05). The number of @entity0 who required nitroglycerine was significantly lower in Group D (p=0.01) and surgeon satisfaction was significantly increased in the same group (p=0.001). Aldrete recovery score >= 9 duration was significantly shorter in Group D (p=0.001). There was no difference between the two groups in terms of recovery room verbal numerical rating scale. CONCLUSIONS: Dexmedetomidine can provide more effective controlled @entity2 and thus contribute to improved visibility of the surgical site.

title: Comparison between magnesium sulfate and dexmedetomidine in controlled XXXX during functional endoscopic sinus surgery.

answer: @entity2


abstract: Airborne particulate matter was collected on filters at various times in Duisburg, Duesseldorf, Muenster and in 2 rural areas. After extraction with organic solvents the extract was partly fractionated and analyzed for @entity4 and 7 other @entity2 ( @entity3 ). The carcinogenicity was examined with the subcutaneous test using 7000 @entity1 in total. The amount of extract required was relatively small. Extracts from suspended matter with a @entity4 content of 0.37 to 1.1 microgram @entity4 brought about @entity0 rates in the range of 30%. On account of the results the following can be concluded: 1. The total extract of atmospheric particulates results in definite dose-response relationship, when the part of the compounds not belonging to the @entity3 is rather low. 2. The @entity3 fractions derived from the suspended matter collected in different cities show the same carcinogenic potency, when they are adjusted to the same @entity4 level by means of concentration or dilution. 3. The @entity3 bear the most important share with respect to the carcinogenic potency of an extract from suspended matter. 4. Numerous compounds (polar substances) which are not classed with the @entity3 are carcinogenic to some extent, partly they are able to inhibit the carcinogenic effect. 5. The dose-response relationship of @entity4 is strongly leveled off in general when all the substances of an extract are present. That means when the dose of an extract is low, the importance of @entity4 becomes less. Therefore a fixed ratio concerning the effect of @entity4 within an extract cannot be given. It has to be examined in particular, which @entity3 and non- @entity3 are necessary to analyse in order to describe the carcinogenic effect due to an extract from airborne particulates. Much more attention is to be payed to the polar substances.

title: [Studies on the tumourigenicity of extracts and their fractions of airborne particulates with the subcutaneous test in the XXXX (author's transl)].

answer: @entity1


abstract: Polygraphy (PG) and polysomnography (PSG) are used in clinical settings in Europe for diagnosing @entity2 ( @entity2 ), but their equivalence in unselected clinical cohorts is unknown. We hypothesized that the method would affect both diagnostic outcomes and disease severity stratification. Data from 11  049 @entity0 in the multi-centre European Sleep Apnea Cohort (ESADA) with suspected @entity2 (male and female, aged 18-80  years) were used in two groups of @entity0 to compare PG (n  =  5745) and PSG (n  =  5304). Respiratory events were scored using the 2007 American Association of Sleep Medicine (AASM) criteria. In subjects who underwent PSG, mean @entity2 index (AHI) using sleep time (AHIPSG 31.0      26.1  h(-1) ) and total analysed time (TAT) (AHITAT 24.7      22.0  h(-1) ) were higher than in subjects who underwent PG (AHIPG 22.0      23.5  h(-1) ) (P  <  0.0001). The @entity1 desaturation index (ODI) was lower in subjects investigated with PG (ODIPG 18.4      21.7  h(-1) ) compared to subjects investigated with PSG (ODIPSG 23.0      25.3  h(-1) ) but not different when the PSG was indexed by TAT (ODITAT 18.6      21.4  h(-1) , P  <  0.65). The proportion of @entity0 with an AHI >=   15 was 64% in the subjects who underwent PSG and 47% in the subjects who underwent PG (P  <  0.001). Overall, @entity0 investigated using PG are likely to have a 30% lower AHI on average, compared to @entity0 investigated by PSG. This study suggests that PG interpreted using standard guidelines results in underdiagnosis and misclassification of @entity2 . We advocate the development of PG-specific guidelines for the management of @entity2 @entity0 .

title: The diagnostic method has a strong influence on classification of XXXX .

answer: @entity2


abstract: AIMS: @entity6 ( @entity6 ) progression is accompanied by systemic oxidative stress, which contributes to an increase in the risk of @entity3 ( @entity3 ). @entity7 (NAC) is among the most studied antioxidants, but its therapeutic benefits in @entity6 -associated CVD remain controversial. Here, we investigated whether NAC could inhibit the oxidative stress induced by @entity11 in vitro and in vivo. MAIN METHODS: Endothelial and smooth muscle cells were challenged with @entity0 uremic or non-uremic sera, and the effects of a pre-treatment with 2mM NAC were evaluated. Reactive @entity1 species (ROS) production, protein oxidation and total @entity9 / @entity12 (tGSH/ @entity12 ) ratios were measured. Five-sixths nephrectomized or sham-operated @entity2 were orally treated (in the drinking water) with 60mg/kg/day NAC or not treated for 53days. Plasma @entity5 / @entity8 reduction potential Eh(Cyss/2Cys) was determined as a novel marker of the systemic oxidative stress. KEY FINDINGS: NAC inhibited all the determined oxidative stress parameters, likely by increasing the t @entity10 / @entity12 ratio, in both cell lines exposed to uremic serum. Orally administered NAC attenuated the systemic oxidative stress in uremic @entity2 . SIGNIFICANCE: The present results indicate that NAC, by preventing @entity10 depletion in vascular cells exposed to uremic serum and by attenuating the systemic oxidative stress during @entity6 progression, emerges as a potential strategy to prevent the oxidative stress induced by @entity4 in the vascular system.

title: XXXX as a potential strategy to attenuate the oxidative stress induced by uremic serum in the vascular system.

answer: @entity7


abstract: BACKGROUND: Previous radiation for @entity3 ( @entity3 ) contra-indicates neoadjuvant chemoradiotherapy for @entity1 ( @entity1 ) because of risk of cumulative radiation dose @entity2 . Postoperative outcomes after proctectomy have not been well studied in these @entity0 who did not receive optimal treatment. METHODS: Eighty-four consecutive male @entity0 underwent surgery for stage II-III mid or low @entity1 between 2002 and 2011. @entity0 who previously received radiation for @entity3 (n   =   8) and @entity0 who had not previously undergone radiation for @entity3 but who received neoadjuvant chemoradiotherapy for @entity1 (n   =   64) were retrospectively compared. RESULTS: Previous radiation for @entity3 was an independent factor that significantly increased intraoperative (25% vs. 1.6%, P   =   0.002) and postoperative morbidities (62.5% vs. 28.1%, P   =   0.028), @entity4 (62.5% vs. 12.5%, P   <   0.001) and definitive stoma rates (25% vs. 17.4%, P   =   0.022). It significantly altered median overall survival (32.0 vs. 130.6 months, P   =   0.05) and local recurrence-free survival rates (14.0 months vs. "median not reached," P   =   0.016). CONCLUSIONS: This is the first report of altered survival rates after proctectomy in @entity0 who had previously received radiation for @entity3 . Postoperative morbidity and definitive defunctioning stoma rates were significantly increased in these @entity0 with poor prognoses. Therapeutic strategies should thus be individualized. Large, multicenter cohort studies are needed. J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Previous radiation for prostate XXXX alters surgical and oncologic outcomes after @entity1 surgery.

answer: @entity1


abstract: BACKGROUND: Previous radiation for @entity3 ( @entity3 ) contra-indicates neoadjuvant chemoradiotherapy for @entity1 ( @entity1 ) because of risk of cumulative radiation dose @entity2 . Postoperative outcomes after proctectomy have not been well studied in these @entity0 who did not receive optimal treatment. METHODS: Eighty-four consecutive male @entity0 underwent surgery for stage II-III mid or low @entity1 between 2002 and 2011. @entity0 who previously received radiation for @entity3 (n   =   8) and @entity0 who had not previously undergone radiation for @entity3 but who received neoadjuvant chemoradiotherapy for @entity1 (n   =   64) were retrospectively compared. RESULTS: Previous radiation for @entity3 was an independent factor that significantly increased intraoperative (25% vs. 1.6%, P   =   0.002) and postoperative morbidities (62.5% vs. 28.1%, P   =   0.028), @entity4 (62.5% vs. 12.5%, P   <   0.001) and definitive stoma rates (25% vs. 17.4%, P   =   0.022). It significantly altered median overall survival (32.0 vs. 130.6 months, P   =   0.05) and local recurrence-free survival rates (14.0 months vs. "median not reached," P   =   0.016). CONCLUSIONS: This is the first report of altered survival rates after proctectomy in @entity0 who had previously received radiation for @entity3 . Postoperative morbidity and definitive defunctioning stoma rates were significantly increased in these @entity0 with poor prognoses. Therapeutic strategies should thus be individualized. Large, multicenter cohort studies are needed. J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Previous radiation for prostate @entity1 alters surgical and oncologic outcomes after XXXX surgery.

answer: @entity1


abstract: OBJECTIVE: To demonstrate the benefit of complexity metrics such as the @entity1 ( @entity1 ) and monitor units (MUs) in multi-institutional audits of @entity0 ( @entity0 ) delivery. METHODS: 39 @entity0 treatment plans were analysed using @entity1 and MU. A virtual phantom planning exercise was planned and independently measured using the PTW Octavius(  ) phantom and seven29(  ) 2D array (PTW-Freiburg GmbH, Freiburg, Germany). @entity1 and MU were compared with the median gamma index pass rates (2%/2 and 3%/3   mm) and plan quality. The treatment planning systems (TPS) were grouped by @entity0 modelling being specifically designed for the linear accelerator manufacturer's own treatment delivery system (Type 1) or independent of vendor for @entity0 delivery (Type 2). Differences in plan complexity ( @entity1 and MU) between TPS types were compared. RESULTS: For Varian(  ) linear accelerators (Varian(  ) Medical Systems, Inc., Palo Alto, CA), @entity1 and MU were significantly correlated with gamma pass rates. Type 2 TPS created poorer quality, more complex plans with significantly higher MUs and @entity1 than Type 1 TPS. Plan quality was significantly correlated with MU for Type 2 plans. A statistically significant correlation was observed between MU and @entity1 for all plans (R   =   -0.84, p   <   0.01). CONCLUSION: MU and @entity1 have a role in assessing plan complexity in audits along with plan quality metrics. Plan complexity metrics give some indication of plan deliverability but should be analysed with plan quality. Advances in knowledge: Complexity metrics were investigated for a national rotational audit involving 34 institutions and they showed value. The metrics found that more complex plans were created for planning systems which were independent of vendor for @entity0 delivery.

title: The role of complexity metrics in a multi-institutional dosimetry audit of XXXX .

answer: @entity0


abstract: BACKGROUND: Recently, two simple clinical scores were published to predict survival in @entity1 @entity0 . Both scores may successfully guide major @entity1 triage, but neither has been independently validated in a hospital setting. METHODS: This is a cohort study with 30-day mortality as the primary outcome to validate two new @entity1 scores-Mechanism, Glasgow @entity3 Scale (GCS), Age, and Pressure (MGAP) score and GCS, Age and Pressure (GAP) score-using data from the UK @entity1 Audit and Research Network. First, an assessment of discrimination, using the area under the receiver operating characteristic (ROC) curve, and calibration, comparing mortality rates with those originally published, were performed. Second, we calculated sensitivity, specificity, predictive values, and likelihood ratios for prognostic score performance. Third, we propose new cutoffs for the risk categories. RESULTS: A total of 79,807 adult (>= 16 years) major @entity1 @entity0 (2000-2010) were included; 5,474 (6.9%) died. Mean (SD) age was 51.5 (22.4) years, median GCS score was 15 (interquartile range, 15-15), and median Injury Severity Score (ISS) was 9 (interquartile range, 9-16). More than 50% of the @entity0 had a low-risk GAP or MGAP score (1% mortality). With regard to discrimination, areas under the ROC curve were 87.2% for GAP score (95% confidence interval, 86.7-87.7) and 86.8% for MGAP score (95% confidence interval, 86.2-87.3). With regard to calibration, 2,390 (3.3%), 1,900 (28.5%), and 1,184 (72.2%) @entity0 died in the low, medium, and high GAP risk categories, respectively. In the low- and medium-risk groups, these were almost double the previously published rates. For MGAP, 1,861 (2.8%), 1,455 (15.2%), and 2,158 (58.6%) @entity0 died in the low-, medium-, and high-risk categories, consonant with results originally published. Reclassifying score point cutoffs improved likelihood ratios, sensitivity and specificity, as well as areas under the ROC curve. CONCLUSION: We found both scores to be valid triage tools to stratify emergency department @entity0 , according to their risk of @entity2 . MGAP calibrated better, but GAP slightly improved discrimination. The newly proposed cutoffs better differentiate risk classification and may therefore facilitate hospital resource allocation. LEVEL OF EVIDENCE: Prognostic study, level II.

title: Validation and reclassification of MGAP and GAP in hospital settings using data from the XXXX Audit and Research Network.

answer: @entity1


abstract: BACKGROUND: As emergency care becomes increasingly regionalized, systems planners must determine how system expansion impacts existing system assets. We hypothesized that accrediting new Level II and III @entity1 centers impacted the @entity1 @entity0 census and severity at a nearby Level I @entity1 center and estimated the magnitude of the impact. METHODS: We conducted an interrupted time series analysis using monthly @entity0 counts during the past 10 years for five @entity1 centers located near one another in Pennsylvania. The Level I center (TC-A) operated for the entire period. A Level II center 39 miles away was accredited after 70 months ( @entity3 ), one Level III center 46 miles away was accredited after 95 months but lost accreditation after 11 months ( @entity4 ), and two other Level III centers 40 miles and 45 miles away were accredited after 107 months ( @entity5 and TC-E). RESULTS: Monthly @entity0 volume at the Level I center, which increased gradually over the study and summed to 25,120 @entity0 , decreased by 10.8% (p < 0.05) when @entity3 was accredited and decreased by an additional 12.9% (p < 0.05) when @entity5 and @entity2 were accredited simultaneously. No change stemmed from temporarily accrediting @entity4 . Ultimately, the Level I center treated 1,903 fewer @entity0 than expected over 51 months, an 11.9% volume reduction, and @entity0 severity remained consistent but mortality decreased. CONCLUSION: Accrediting Level II and Level III @entity1 centers reduced @entity0 volume and reduced overall mortality at a nearby Level I center. Strategic planning of statewide @entity1 systems can help balance rapid access to care with maintenance of adequate annual @entity0 volumes of critically injured @entity0 . LEVEL OF EVIDENCE: Epidemiologic study, Level IV.

title: Impact of adding Level II and III @entity1 centers on volume and disease severity at a nearby Level I XXXX center.

answer: @entity1


abstract: BACKGROUND: As emergency care becomes increasingly regionalized, systems planners must determine how system expansion impacts existing system assets. We hypothesized that accrediting new Level II and III @entity1 centers impacted the @entity1 @entity0 census and severity at a nearby Level I @entity1 center and estimated the magnitude of the impact. METHODS: We conducted an interrupted time series analysis using monthly @entity0 counts during the past 10 years for five @entity1 centers located near one another in Pennsylvania. The Level I center (TC-A) operated for the entire period. A Level II center 39 miles away was accredited after 70 months ( @entity3 ), one Level III center 46 miles away was accredited after 95 months but lost accreditation after 11 months ( @entity4 ), and two other Level III centers 40 miles and 45 miles away were accredited after 107 months ( @entity5 and TC-E). RESULTS: Monthly @entity0 volume at the Level I center, which increased gradually over the study and summed to 25,120 @entity0 , decreased by 10.8% (p < 0.05) when @entity3 was accredited and decreased by an additional 12.9% (p < 0.05) when @entity5 and @entity2 were accredited simultaneously. No change stemmed from temporarily accrediting @entity4 . Ultimately, the Level I center treated 1,903 fewer @entity0 than expected over 51 months, an 11.9% volume reduction, and @entity0 severity remained consistent but mortality decreased. CONCLUSION: Accrediting Level II and Level III @entity1 centers reduced @entity0 volume and reduced overall mortality at a nearby Level I center. Strategic planning of statewide @entity1 systems can help balance rapid access to care with maintenance of adequate annual @entity0 volumes of critically injured @entity0 . LEVEL OF EVIDENCE: Epidemiologic study, Level IV.

title: Impact of adding Level II and III XXXX centers on volume and disease severity at a nearby Level I @entity1 center.

answer: @entity1


abstract: @entity4 resistant @entity7 (VREF) ia an emerging and challenging nosocomial pathogen. This study aimed to determine the prevalence, risk factors and clonal relationships between different VREF isolates in the intensive care units (ICUs) of the university hospitals in our geographic location. This prospective study was conducted from July, 2012 until September, 2013 on 781 @entity0 who were admitted to the ICUs of the Mansoura University Hospitals (MUHs), and fulfilled the healthcare-associated @entity2 (HAI) criteria. Susceptibility testing was determined using the disk diffusion method. The clonal relationships were evaluated with pulsed field gel electrophoresis (PFGE). Out of 52 @entity7 isolates, 12 (23.1%) were @entity4 resistant. The significant risk factors for the @entity2 were: transfer to the ICU from a ward, @entity1 , an extended ICU stay and use of third-generation @entity6 , @entity3 , or @entity5 . PFGE with the 12 isolates showed 9 different patterns; 3 belonged to the same pulsotype and another 2 carried a second pulsotypes. The similar pulsotypes isolates were isolated from ICUs of one hospital (EICUs); however, all of the isolates from the other ICUs had different patterns. Infection control policy, in conjunction with antibiotic stewardship, is important to combat VREF transmission in these high-risk @entity0 .

title: Healthcare-associated XXXX resistant @entity7 infections in the Mansoura University Hospitals intensive care units, Egypt.

answer: @entity4


abstract: @entity4 resistant @entity7 (VREF) ia an emerging and challenging nosocomial pathogen. This study aimed to determine the prevalence, risk factors and clonal relationships between different VREF isolates in the intensive care units (ICUs) of the university hospitals in our geographic location. This prospective study was conducted from July, 2012 until September, 2013 on 781 @entity0 who were admitted to the ICUs of the Mansoura University Hospitals (MUHs), and fulfilled the healthcare-associated @entity2 (HAI) criteria. Susceptibility testing was determined using the disk diffusion method. The clonal relationships were evaluated with pulsed field gel electrophoresis (PFGE). Out of 52 @entity7 isolates, 12 (23.1%) were @entity4 resistant. The significant risk factors for the @entity2 were: transfer to the ICU from a ward, @entity1 , an extended ICU stay and use of third-generation @entity6 , @entity3 , or @entity5 . PFGE with the 12 isolates showed 9 different patterns; 3 belonged to the same pulsotype and another 2 carried a second pulsotypes. The similar pulsotypes isolates were isolated from ICUs of one hospital (EICUs); however, all of the isolates from the other ICUs had different patterns. Infection control policy, in conjunction with antibiotic stewardship, is important to combat VREF transmission in these high-risk @entity0 .

title: Healthcare-associated @entity4 resistant XXXX infections in the Mansoura University Hospitals intensive care units, Egypt.

answer: @entity7


abstract: BACKGROUND CONTEXT: Corrective surgery for @entity2 ( @entity2 ) leads to vertical growth arrest of the instrumented spine. This might be offset by the immediate gain in spinal height (SH) as a result of correction of the curvature. PURPOSE: This study aimed to identify predictors of gain in SH following corrective surgery for @entity2 . We present a unique model to predict postoperative height prior to intervention, which could contribute to the preoperative counseling and consenting process. STUDY DESIGN: This was a retrospective case series. All surgeries were performed by one of four substantive pediatric spinal surgeons within a single regional center over a 3.5-year period. @entity0 SAMPLE: There were 104 @entity0 who had instrumented posterior spinal fusion for @entity2 included. There were 93 females, and the age range was from 11 to 17 years. All @entity0 had posterior instrumented fusion using rods and anchors (pedicle screws  hooks). OUTCOME MEASURES: Postoperative SH was the primary outcome measure. The SH (C7-L5) and Cobb angles were measured from a pre- and postoperative standing X-ray of each @entity0 . METHODS: Variables associated with @entity0 (demographic and radiological) and the surgical constructs were analyzed for predictability of @entity1 . A model was derived including only significant predictors of substantive importance using hierarchical regression methods. Cross-validation procedures verified the adequacy of the model fit. Analysis was performed using IBM SPSS Statistics for Windows version 20.0 (IBM Corp. Armonk, NY, USA). RESULTS: The major curve was thoracic in 90% of cases. The number of vertebrae fused ranged from 5 to 15. The average preoperative Cobb angle was 66  , with an average correction of 45  . The average change in SH was 4.66   cm (SD 2.13   cm). The model presented included preoperative height, preoperative Cobb angle, and number of vertebrae within the construct, with coefficients of 1.00 (95% CI: 0.90, 1.09), 0.067 (95% CI: 0.039, 0.095), and 0.26 (95% CI: 0.11, 0.41), respectively. This model had an adjusted-R(2) value of 0.83 and a R(2) for prediction of 0.79, and can be shown to have similar predictive capability as a model comprising a wider range of predictors. CONCLUSION: The greatest postoperative height values following posterior spinal fusion for @entity2 could be expected from a @entity0 with greater preoperative height and Cobb angle, and whose construct spans a large number of vertebrae.

title: Change in spinal height following correction of XXXX .

answer: @entity2


abstract: OBJECTIVES: To investigate the optimal threshold of subtraction method for quantification of air trapping on co-registered CT in @entity1 @entity0 in correlation with pulmonary function parameters. METHODS: From June 2005 to October 2010, 174 @entity0 were included in our study. Inspiration and expiration CT were performed followed by non-rigid registration using in-house software. The subtraction value per voxel between inspiration and registered expiration CT was obtained, and volume fraction of air trapping (air trapping index, ATI), using variable thresholds was calculated. ATI, expiration/inspiration ratio of mean lung density (E/I @entity3 ) and the percentage of lung voxels below -856  HU on expiration CT (Exp-856) were correlated with FEF25-75% and RV/TLC. RESULTS: The highest correlation coefficient with FEF25-75% was -0.656, using the threshold of 80  HU. As for RV/TLC, the highest correlation coefficient was 0.664, using the threshold of 30  HU. When plotting the relationship between subtraction thresholds and FEF25-75% and RV/TLC, the threshold of 60  HU was most suitable (r   =   -0.649 and 0.651). Those correlation coefficients were comparable to the results with E/I @entity3 (r   =   -0.670 and 0.657) and Exp-856 (r   =   -0.604 and 0.565). CONCLUSIONS: The optimal threshold for quantification of air trapping was 60  HU and showed comparable correlations with pulmonary function parameters. KEY POINTS:     The optimal CT threshold of subtraction method for air trapping was 60  HU.     ATI with 60  HU threshold was comparable to E/I @entity3 and Exp -856 .     @entity2 may substantially contribute to air trapping with statistical significance (P   <   0.001).

title: Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in XXXX @entity0 .

answer: @entity1


abstract: OBJECTIVES: To investigate the optimal threshold of subtraction method for quantification of air trapping on co-registered CT in @entity1 @entity0 in correlation with pulmonary function parameters. METHODS: From June 2005 to October 2010, 174 @entity0 were included in our study. Inspiration and expiration CT were performed followed by non-rigid registration using in-house software. The subtraction value per voxel between inspiration and registered expiration CT was obtained, and volume fraction of air trapping (air trapping index, ATI), using variable thresholds was calculated. ATI, expiration/inspiration ratio of mean lung density (E/I @entity3 ) and the percentage of lung voxels below -856  HU on expiration CT (Exp-856) were correlated with FEF25-75% and RV/TLC. RESULTS: The highest correlation coefficient with FEF25-75% was -0.656, using the threshold of 80  HU. As for RV/TLC, the highest correlation coefficient was 0.664, using the threshold of 30  HU. When plotting the relationship between subtraction thresholds and FEF25-75% and RV/TLC, the threshold of 60  HU was most suitable (r   =   -0.649 and 0.651). Those correlation coefficients were comparable to the results with E/I @entity3 (r   =   -0.670 and 0.657) and Exp-856 (r   =   -0.604 and 0.565). CONCLUSIONS: The optimal threshold for quantification of air trapping was 60  HU and showed comparable correlations with pulmonary function parameters. KEY POINTS:     The optimal CT threshold of subtraction method for air trapping was 60  HU.     ATI with 60  HU threshold was comparable to E/I @entity3 and Exp -856 .     @entity2 may substantially contribute to air trapping with statistical significance (P   <   0.001).

title: Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in @entity1 XXXX .

answer: @entity0


abstract: UNASSIGNED: A method based on the combination of hollow fiber liquid-liquid-liquid microextraction and solid-phase microextraction (SPME) followed by gas chromatography-electron capture detection was developed for the determination of @entity3 in water and wastewater samples. Silica microstructures fabricated on the surface of a stainless steel wire were coated by an organic solvent and used as a SPME fiber. The analytes were extracted through a hollow fiber membrane containing @entity7 from sample solution to an alkaline aqueous acceptor phase. They were then extracted and in situ derivatized on the SPME fiber using @entity4 . Experimental parameters such as the type of extraction solvent, acceptor phase @entity2 concentration, donor phase @entity1 concentration, the amount of derivatizing reagent, salt concentration, stirring rate and extraction time were investigated and optimized. The precision of the method for the analytes at 0.02-30 gL(-1) concentration level ranged from 7.1 to 10.2% (as intra-day relative standard deviation) and 6.4 to 9.8% (as inter-day relative standard deviation). The linear dynamic ranges were in the interval of 5-500 gL(-1), 0.05-5 gL(-1), 0.02-1 gL(-1) and 0.001-0.5 gL(-1) for @entity8 , @entity6 , @entity5 and @entity0 , respectively. The enrichment factors were between 432 and 785. The limits of detection were in the range of 0.0004-1.2 gL(-1). Tap water, well water and wastewater samples were also analyzed to evaluate the method capability for real sample analysis.

title: Hollow fiber liquid-liquid-liquid microextraction followed by solid-phase microextraction and in situ derivatization for the determination of XXXX by gas chromatography-electron capture detection.

answer: @entity3


abstract: BACKGROUND: Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used modalities in the treatment of @entity2 . However, despite its high efficacy, conventional Goeckerman treatment has fallen out of favor in recent years and some institutions are now using NBUVB with coal tar as their regimen. OBJECTIVE: To evaluate the efficacy of NB-UVB, Goeckerman therapy and the effect of addition of @entity1 to the treatment regimen in the treatment of @entity2 ,. @entity0 AND METHODS: A retrospective analysis of 65 @entity0 who underwent 81 courses of treatment in our department was undertaken. The efficacy of NB-UVB and Goeckerman therapy individually, and in combination with @entity3 was assessed. Data were analysed to evaluate the contribution of @entity3 to these modalities. RESULTS: PASI-75 responses in the NB-UVB, @entity1 + NB-UVB (re-NB), Goeckerman and @entity1 + Goeckerman (re-Goeckerman) groups were achieved for 12 of 31 @entity0 (39%), 13 of 21 @entity0 (62%), 15 of 17 @entity0 (88%) and 10 of 12 @entity0 , respectively. The addition of @entity3 to both modalities reduced both the number of sessions and the cumulative ultraviolet-B dose delivered. LIMITATIONS: This is a retrospective study, the @entity0 were not randomized and the number of @entity0 in the treatment groups were dissimilar. CONCLUSION: Goeckerman therapy is more effective than NB-UVB phototherapy. Although the addition of @entity3 to both NB-UVB and Goeckerman therapy did not contribute to treatment outcomes in terms of PASI-75 responses, it enabled a reduction in UV exposures and enhanced efficacy.

title: Narrow band ultraviolet-B versus Goeckerman therapy for @entity2 with and without XXXX : A retrospective study.

answer: @entity3


abstract: BACKGROUND: Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used modalities in the treatment of @entity2 . However, despite its high efficacy, conventional Goeckerman treatment has fallen out of favor in recent years and some institutions are now using NBUVB with coal tar as their regimen. OBJECTIVE: To evaluate the efficacy of NB-UVB, Goeckerman therapy and the effect of addition of @entity1 to the treatment regimen in the treatment of @entity2 ,. @entity0 AND METHODS: A retrospective analysis of 65 @entity0 who underwent 81 courses of treatment in our department was undertaken. The efficacy of NB-UVB and Goeckerman therapy individually, and in combination with @entity3 was assessed. Data were analysed to evaluate the contribution of @entity3 to these modalities. RESULTS: PASI-75 responses in the NB-UVB, @entity1 + NB-UVB (re-NB), Goeckerman and @entity1 + Goeckerman (re-Goeckerman) groups were achieved for 12 of 31 @entity0 (39%), 13 of 21 @entity0 (62%), 15 of 17 @entity0 (88%) and 10 of 12 @entity0 , respectively. The addition of @entity3 to both modalities reduced both the number of sessions and the cumulative ultraviolet-B dose delivered. LIMITATIONS: This is a retrospective study, the @entity0 were not randomized and the number of @entity0 in the treatment groups were dissimilar. CONCLUSION: Goeckerman therapy is more effective than NB-UVB phototherapy. Although the addition of @entity3 to both NB-UVB and Goeckerman therapy did not contribute to treatment outcomes in terms of PASI-75 responses, it enabled a reduction in UV exposures and enhanced efficacy.

title: Narrow band ultraviolet-B versus Goeckerman therapy for XXXX with and without @entity3 : A retrospective study.

answer: @entity2


abstract: BACKGROUND: Bronchial artery embolisation (BAE) becomes a mainstay in the treatment of @entity5 . OBJECTIVE: To characterise @entity0 with @entity5 undergoing bronchial artery angiography (BAA) for embolisation, evaluating outcomes. METHODS: We retrospectively evaluated @entity0 with acute severe or chronic recurrent @entity5 admitted to the Pulmonology department and submitted to BAA for purpose of embolisation. RESULTS: A total of 88 @entity0 were submitted to BAA, 47 (53.4%) were male, with a mean age of 61.4  15.8 years. In 64 (72.7%) @entity0 , @entity5 presented as chronic recurrent episodes. @entity5 was considered severe in 40 (45.5%) @entity0 . @entity4 (other than @entity3 ) (n=35; 38.0%) and @entity1 sequelae (n=31; 35.2) were the major aetiology for @entity5 . The main angiographic abnormality was @entity2 and tortuosity (n=68; 77.3%). BAE was performed in 67 (76.1%) of the 88 @entity0 submitted to BAA. Immediate success was achieved in 66 (98.5%) @entity0 . Recurrence of @entity5 occurred in 25 (37.3%) @entity0 , and was related to presence of shunting (p=0.049). The procedure-related complications were self-limited. CONCLUSION: Our results suggest that BAE is a safe and effective treatment for acute severe and chronic recurrent @entity5 , supporting the current literature. Besides this, bleeding recurrence was relatively high, and correlated with presence of systemic pulmonary shunting.

title: Bronchial artery embolisation in management of XXXX - A retrospective analysis in a tertiary university hospital.

answer: @entity5


abstract: BACKGROUND: The purpose of the present study was to investigate the existence of @entity5 in the white matter circuit in @entity1 @entity0 and its relationship to @entity3 episodes. To target the prevention of @entity3 , we also investigated the relationship between lymphocyte subsets and @entity2 in @entity0 . METHODS: @entity0 included 18 @entity0 with acute @entity4 and 22 healthy control subjects. Diffusion tensor imaging was performed. Whole-brain voxel-based analysis was used to compare fractional anisotropy (FA) between groups. Blood samples were obtained, and the lymphocyte subsets were evaluated using flow cytometry. Follow-up examinations were conducted on 12 @entity0 at 6 months. RESULTS: FA was decreased in the bilateral anterior limb of the internal capsule in @entity1 @entity0 . At the 6-month follow-up examination, there was a significant increase in FA, which was associated with a lower @entity3 scale score. @entity0 showed a decreased percentage of circulated regulatory T lymphocytes, and the degree of reduction was related to the decrease in the FA value in the internal capsule. CONCLUSIONS: FA reductions in the anterior limb of the internal capsule cause @entity6 and confer a biological vulnerability, which in combination with environmental stressors results in the onset of @entity3 . Our findings also demonstrated the possibility of preventing @entity1 by targeting the role of regulatory T lymphocytes in brain tissue repair and regeneration after @entity1 .

title: XXXX in white matter, regulatory T lymphocytes, and @entity3 after @entity1 .

answer: @entity5


abstract: BACKGROUND: The purpose of the present study was to investigate the existence of @entity5 in the white matter circuit in @entity1 @entity0 and its relationship to @entity3 episodes. To target the prevention of @entity3 , we also investigated the relationship between lymphocyte subsets and @entity2 in @entity0 . METHODS: @entity0 included 18 @entity0 with acute @entity4 and 22 healthy control subjects. Diffusion tensor imaging was performed. Whole-brain voxel-based analysis was used to compare fractional anisotropy (FA) between groups. Blood samples were obtained, and the lymphocyte subsets were evaluated using flow cytometry. Follow-up examinations were conducted on 12 @entity0 at 6 months. RESULTS: FA was decreased in the bilateral anterior limb of the internal capsule in @entity1 @entity0 . At the 6-month follow-up examination, there was a significant increase in FA, which was associated with a lower @entity3 scale score. @entity0 showed a decreased percentage of circulated regulatory T lymphocytes, and the degree of reduction was related to the decrease in the FA value in the internal capsule. CONCLUSIONS: FA reductions in the anterior limb of the internal capsule cause @entity6 and confer a biological vulnerability, which in combination with environmental stressors results in the onset of @entity3 . Our findings also demonstrated the possibility of preventing @entity1 by targeting the role of regulatory T lymphocytes in brain tissue repair and regeneration after @entity1 .

title: @entity5 in white matter, regulatory T lymphocytes, and @entity3 after XXXX .

answer: @entity1


abstract: BACKGROUND: The purpose of the present study was to investigate the existence of @entity5 in the white matter circuit in @entity1 @entity0 and its relationship to @entity3 episodes. To target the prevention of @entity3 , we also investigated the relationship between lymphocyte subsets and @entity2 in @entity0 . METHODS: @entity0 included 18 @entity0 with acute @entity4 and 22 healthy control subjects. Diffusion tensor imaging was performed. Whole-brain voxel-based analysis was used to compare fractional anisotropy (FA) between groups. Blood samples were obtained, and the lymphocyte subsets were evaluated using flow cytometry. Follow-up examinations were conducted on 12 @entity0 at 6 months. RESULTS: FA was decreased in the bilateral anterior limb of the internal capsule in @entity1 @entity0 . At the 6-month follow-up examination, there was a significant increase in FA, which was associated with a lower @entity3 scale score. @entity0 showed a decreased percentage of circulated regulatory T lymphocytes, and the degree of reduction was related to the decrease in the FA value in the internal capsule. CONCLUSIONS: FA reductions in the anterior limb of the internal capsule cause @entity6 and confer a biological vulnerability, which in combination with environmental stressors results in the onset of @entity3 . Our findings also demonstrated the possibility of preventing @entity1 by targeting the role of regulatory T lymphocytes in brain tissue repair and regeneration after @entity1 .

title: @entity5 in white matter, regulatory T lymphocytes, and XXXX after @entity1 .

answer: @entity3


abstract: BACKGROUND: Endocrine disrupting chemicals (EDCs) present in the environment may disrupt thyroid hormones, which in early life are essential for brain development. Observational studies regarding this topic are still limited, however as the presence of chemicals in the environment is ubiquitous, further research is warranted. The objective of the current study was to assess the association between exposure markers of various EDCs and thyroxine (T4) levels in newborns in a mother- @entity0 cohort in the Netherlands. METHODS: Exposure to @entity5 ( @entity5 ), three @entity4 ( @entity4 ) metabolites, @entity8 ( @entity8 ), polychlorinated biphenyl ( @entity3 )-153, @entity6 ( @entity7 ), and @entity1 ( @entity2 ) was determined in cord plasma or breast milk, and information on T4 levels in heel prick blood spots was obtained through the neonatal screening programme in the Netherlands. Linear regression models were composed to determine associations between each of the compounds and T4, which were stratified for gender and adjusted for a priori defined covariates. RESULTS: Mean T4 level was 86.9 nmol/L (n = 83). @entity0 in the highest quartile of @entity5 and @entity2 exposure showed an increased T4 level compared to the lowest quartile with both crude and fully adjusted models ( @entity5 > 107.50 ng/L, +24.8 nmol/L, 95% CI 0.79, 48.75; @entity2 > 1200 ng/L, +38.6 nmol/L, 95% CI 13.34, 63.83). In @entity0 a lower T4 level was seen in the second quartile of exposure for both @entity7 and @entity2 , however after fully adjusting the models these associations were attenuated. No effects were observed for the other compounds. CONCLUSION: @entity5 and perfluorinated alkyl acids may be associated with T4 in a sex-specific manner. These results should however be interpreted with caution, due to the relatively small study population. More research is warranted, as studies on the role of environmental contaminants in this area are still limited.

title: Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in XXXX - a Dutch prospective cohort study.

answer: @entity0


abstract: UNASSIGNED: Abstract Purpose: A port-a-cath is a device implanted under the skin for continuous drug administration. It is composed of a catheter and a @entity2 or metal reservoir. A simulation study was done to assess the impact of a port-a-cath implant on the quality of superficial @entity1 treatments applied using the Lucite cone applicator (LCA). Methods: Specific absorption rate (SAR) and temperature distributions were predicted using SEMCAD-X (version 14.8). We simulated 72 arrangements: two LCA-implant set-ups (central port-a-cath or at an edge below the LCA footprint), six translations of the LCA per set-up, two LCA orientations (Parallel or perpendicular electric field direction) per set-up, two implant materials ( @entity3 or metal) and a control without port-a-cath. Treatment quality was quantified by the average 1   g SAR coverage (CV25%), i.e. volume within the 25% iso-SAR surface, and the volume within the 40     C iso-temperature surface (CV40     C). Results: CV25% reduced with a @entity3 port-a-cath located below the LCA footprint. In the worst scenario, only 64% of the CV25% of the control set-up was achieved. For a metal port-a-cath below the LCA aperture, dramatic reductions of CV25% were predicted: worst scenario down to 12.1% of the control CV25%. For the CV40     C the worst case values were 74.5% and 6.5%, for @entity3 and metal implants, respectively. Conclusions: A @entity2 port-a-cath below the LCA had a smaller effect on treatment quality than a metal implant. Based on this study we recommend verifying heating quality by 3D @entity0 -specific treatment planning when a port-a-cath is located below the footprint of the applicator.

title: Impact of XXXX and metal port-a-cath implants on superficial @entity1 treatment quality.

answer: @entity2