abstract: The Lund Clinic serves a population of 1.46 million inhabitants. During the calendar year 1981, 72 @entity0 presented with a ruptured supratentorial @entity2 , diagnosed either at angiography or at autopsy. Upon admission, 60% of the @entity0 were in good condition and 40% were in poor condition. Eighty-three per cent were admitted within 72 hours after the @entity3 ( @entity3 ). In the total series, 50% made a good recovery; the overall management morbidity was 19% and the management mortality was 31%. Thirty-one @entity0 in Grades I-III underwent early operation (43% of the total series), with a favorable outcome in 74% and 7% mortality. Of the 35 @entity0 who were admitted early and in good condition, 71% made a good recovery, and the management mortality was 9%. These figures may be compared to the 51% favorable outcome and 27% mortality reported from the Cooperative @entity2 Study with late operation. In the early operation cases, the incidence of significant arterial narrowing at postoperative angiography performed on Day 9 +/- 2 after @entity3 was 30% and the incidence of permanent @entity1 of delayed onset was 10%. Two of the early operation @entity0 developed permanent symptomatic @entity4 .

title: Early management of XXXX .

answer: @entity3


abstract: UNASSIGNED: Inhalation of @entity3 (NO) produces selective pulmonary vasodilation and is an effective therapy for treating @entity1 in adults and @entity0 . In the United States, the average cost of 5 days of inhaled NO for persistent @entity1 of the newborn is about  14,000. NO therapy involves gas cylinders and distribution, a complex delivery device, gas monitoring and calibration equipment, and a trained respiratory therapy staff. The objective of this study was to develop a lightweight, portable device to serve as a simple and economical method of producing pure NO from air for bedside or portable use. Two NO generators were designed and tested: an offline NO generator and an inline NO generator placed directly within the inspiratory line. Both generators use pulsed electrical discharges to produce therapeutic range NO (5 to 80 parts per million) at gas flow rates of 0.5 to 5 liters/min. NO was produced from air, as well as gas mixtures containing up to 90% @entity6 and 10% N2. Potentially toxic gases produced in the plasma, including @entity9 ( @entity8 ) and @entity4 (O3), were removed using a @entity7 scavenger. An @entity5 spark electrode produced the lowest ratio of @entity8 /NO. In @entity2 with @entity1 , breathing electrically generated NO produced pulmonary vasodilation and reduced pulmonary arterial pressure and pulmonary vascular resistance index. In conclusion, electrical plasma NO generation produces therapeutic levels of NO from air. After scavenging to remove @entity8 and O3 and filtration to remove particles, electrically produced NO can provide safe and effective treatment of @entity1 .

title: Producing XXXX by pulsed electrical discharge in air for portable inhalation therapy.

answer: @entity3


abstract: BACKGROUND: @entity2 is a very rare paediatric @entity1 . This study was performed in order to understand clinical features and prognosis of @entity2 in @entity0 and adolescents. METHODS: 443 @entity0    18years of age with @entity2 were prospectively registered with the German Central @entity2 Registry between 1983 and 2011. Cases were collected from 58 participating centres. 276 paediatric cases with a follow-up >3months were evaluated for survival probabilities and prognostic factors by Kaplan-Meier method. RESULTS: Age of diagnosis ranged from 3months to 18years (median age 16years). The male to female ratio was 0.8 (202 male, 240 female). Most @entity2 were located at the trunk (n=195) and the lower extremity (n=114). @entity0 with >3months of follow-up (median 55months) showed an @entity4 ( @entity4 ) of 94.8% in 5years. Survival according to @entity1 stage was 98.5% for stage I (n=190), 91.1% for stage II (n=39) and 53.0% for stage III/IV @entity1 (n=11). Worse outcome was seen in @entity0 with @entity2 ( @entity4 77.9%, n=42) compared to superficial spread histotype ( @entity4 100%, n=138) or other histotype ( @entity4 96.9%, n=88) (p<0.0001), in case of thicker @entity1 (Clark level IV or V, @entity4 87.1%, n=84) compared to thinner @entity1 (Clark level I, II, III, @entity4 99.1%, n=164) (p=0.0008) and in case of @entity3 ( @entity4 65.6%, n=17) compared to no @entity3 ( @entity4 99.2%, n=182). CONCLUSION: @entity0 and @entity1 characteristics in paediatric @entity2 @entity0 show no evident differences to adult @entity2 cases. The same clinical approach as in adults should be used.

title: 443 paediatric cases of @entity2 registered with the German Central XXXX Registry between 1983 and 2011.

answer: @entity2


abstract: BACKGROUND: @entity2 is a very rare paediatric @entity1 . This study was performed in order to understand clinical features and prognosis of @entity2 in @entity0 and adolescents. METHODS: 443 @entity0    18years of age with @entity2 were prospectively registered with the German Central @entity2 Registry between 1983 and 2011. Cases were collected from 58 participating centres. 276 paediatric cases with a follow-up >3months were evaluated for survival probabilities and prognostic factors by Kaplan-Meier method. RESULTS: Age of diagnosis ranged from 3months to 18years (median age 16years). The male to female ratio was 0.8 (202 male, 240 female). Most @entity2 were located at the trunk (n=195) and the lower extremity (n=114). @entity0 with >3months of follow-up (median 55months) showed an @entity4 ( @entity4 ) of 94.8% in 5years. Survival according to @entity1 stage was 98.5% for stage I (n=190), 91.1% for stage II (n=39) and 53.0% for stage III/IV @entity1 (n=11). Worse outcome was seen in @entity0 with @entity2 ( @entity4 77.9%, n=42) compared to superficial spread histotype ( @entity4 100%, n=138) or other histotype ( @entity4 96.9%, n=88) (p<0.0001), in case of thicker @entity1 (Clark level IV or V, @entity4 87.1%, n=84) compared to thinner @entity1 (Clark level I, II, III, @entity4 99.1%, n=164) (p=0.0008) and in case of @entity3 ( @entity4 65.6%, n=17) compared to no @entity3 ( @entity4 99.2%, n=182). CONCLUSION: @entity0 and @entity1 characteristics in paediatric @entity2 @entity0 show no evident differences to adult @entity2 cases. The same clinical approach as in adults should be used.

title: 443 paediatric cases of XXXX registered with the German Central @entity2 Registry between 1983 and 2011.

answer: @entity2


abstract: BACKGROUND: Vagus nerve stimulation (VNS) has been approved for the treatment of refractory partial epi.lepsy in adults and @entity0 over 12 years of age. Later on, its application expanded to include younger @entity0 and other types of @entity1 . We report our experience with this treatment modality for @entity1 in Saudi Arabia. DESIGN AND SETTINGS: Open-label, uncontrolled, retrospective study of @entity0 with @entity1 , who were treated with VNS in a tertiary care hospital from January 2010 to June 2013. @entity0 AND METHODS: Collected data included 26 @entity0 ' demographics, @entity1 characteristics, sei.zure frequency, and treatment history. @entity0 with a follow-up duration of minimum 12 months were included in the analysis. The examined outcome measures were @entity2 reduction rates, @entity3 ( @entity3 ) burden, and impact on @entity0 ' quality of life (QOL). RESULTS: Onset of @entity2 was from birth to 30 years. @entity0 ' ages at VNS implantation ranged from 4 to 38 years (18.9 [8.7] years). @entity1 was classified as focal in 8 @entity0 (30%), multifocal in 9 @entity0 (35%), and generalized in 9 @entity0 (35%). The average number of @entity3 failed before VNS was 4.2 (1.4). Greater than 50% @entity2 reduction was achieved in 50% of @entity0 at 3 months, 67% at 6 months, 73% at 12 months, and 78% at 24 months. There was no significant reduction in @entity3 burden during the same period. Subjective QOL improvement was reported by 72% of @entity0 at 3 months, 83% at 6 months, 78% at 12 months, and 73% at 24 months after VNS. Minor adverse effects were reported in 27% of @entity0 . One @entity0 had the device replaced due to malfunction. CONCLUSION: The experience with VNS in a single center in Saudi Arabia confirms that it is a safe and effec.tive adjunctive therapy for @entity1 in adult and pediatric @entity0 .

title: Vagus nerve stimulation for XXXX : experience from Saudi Arabia.

answer: @entity1


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity0 @entity3 (BRD) complex in Holstein pre-weaned dairy @entity0 . Systematic @entity2 ( @entity2 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity0 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity0 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity0 ) from North America were studied. All @entity0 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity2 (cutoff used >= 1cm of @entity1 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity2 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity2 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity2 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the XXXX respiratory scoring chart and ultrasonography for the diagnosis of @entity0 @entity3 in pre-weaned dairy @entity0 .

answer: @entity0


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity0 @entity3 (BRD) complex in Holstein pre-weaned dairy @entity0 . Systematic @entity2 ( @entity2 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity0 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity0 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity0 ) from North America were studied. All @entity0 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity2 (cutoff used >= 1cm of @entity1 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity2 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity2 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity2 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the @entity0 respiratory scoring chart and ultrasonography for the diagnosis of XXXX @entity3 in pre-weaned dairy @entity0 .

answer: @entity0


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity0 @entity3 (BRD) complex in Holstein pre-weaned dairy @entity0 . Systematic @entity2 ( @entity2 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity0 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity0 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity0 ) from North America were studied. All @entity0 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity2 (cutoff used >= 1cm of @entity1 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity2 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity2 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity2 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the @entity0 respiratory scoring chart and ultrasonography for the diagnosis of @entity0 @entity3 in pre-weaned dairy XXXX .

answer: @entity0


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity0 @entity3 (BRD) complex in Holstein pre-weaned dairy @entity0 . Systematic @entity2 ( @entity2 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity0 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity0 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity0 ) from North America were studied. All @entity0 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity2 (cutoff used >= 1cm of @entity1 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity2 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity2 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity2 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the @entity0 respiratory scoring chart and ultrasonography for the diagnosis of @entity0 XXXX in pre-weaned dairy @entity0 .

answer: @entity3


abstract: BACKGROUND CONTEXT: The most common adverse event after a lumbar puncture (LP) is a @entity1 : In anaesthesiology, well studied is the protective effect of atraumatic spinal needles, and they are routinely used. However, this is less well known in diagnostic LP, and neurologists use atraumatic needles in less than 2% of times. PURPOSE: The purpose of this study was to define the impact of needle type, atraumatic (Sprotte [S]) versus traumatic (Quincke [Q]) on postdural puncture @entity1 (PDPH) incidence. STUDY DESIGN: The study is based on a prospective, randomized, and simple-blinded clinical trial. @entity0 SAMPLE: @entity0 older than 14 years were scheduled for a diagnostic or therapeutic LP. OUTCOME MEASURES: The outcome measure included the development of PDPH according to the International @entity1 Association criteria. METHODS: @entity0 fulfilling eligibility criteria were randomly allocated to one of two kinds of spinal needle: atraumatic or S-type or traumatic or Q-type. They were interviewed on days 2 and 7 about the development of PDPH. RESULTS: The incidence of PDPH was 22.43% with Q-type needle and 8.51% with S-type needle, p=.04. The duration of PDPH in @entity0 in the S-type was 1 day or less, compared with a median of 4.14 days in the Q-type (p=.00). In the logistic regression model, the S-type needle together with the age of the @entity0 were the only two statistically significant factors in the development of postlumbar puncture @entity1 (PLPH), both of them being protective. CONCLUSIONS: We found a lower incidence of PDPH with atraumatic needles, and it was statistically significant compared with the traumatic needles. Our study confirms the effectiveness of the atraumatic needles to prevent PDPH.

title: Postdural puncture XXXX : impact of needle type, a randomized trial.

answer: @entity1


abstract: BACKGROUND AND STUDY AIMS: Endoscopic implantation of a duodenal-jejunal bypass liner (DJBL) is a novel bariatric technique to induce @entity4 and remission of @entity1 . Placement of the DJBL mimics the bypass component of the Roux-en-Y gastric bypass (RYGB) procedure. In this observational study, we evaluated improvement of glycemic control and @entity4 in the course of the treatment (0-24 weeks after DJBL implantation) and analyzed accompanying gut hormone responses. @entity0 AND METHODS: 12 @entity2 individuals with @entity3 2 @entity1 were selected for DJBL implantation. Body weight, fat mass, and fasting plasma levels of @entity5 , insulin, C-peptide, and glycated hemoglobin (HbA1c), were analyzed at 0, 1, 4 and 24 weeks post-implant. Fasting ghrelin, gastric inhibitory peptide (GIP), and glucagon-like peptide ( @entity6 ) were determined at 0, 1 and 4 weeks post-implant. RESULTS: Besides significant @entity4 , fat mass, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index were also significantly decreased after DJBL implantation and a 42% reduction was found in @entity1 medication (P<0.05). The fasting @entity6 response in the first 4 weeks post-implant was significantly correlated with the fasting insulin and HOMA-IR response. Fasting ghrelin was found to be significantly elevated, in contrast to the decrease in ghrelin that is found after RYGB surgery. CONCLUSIONS: DJBL implantation provoked significant @entity4 , a decrease in fat mass, and an early remission of @entity3 2 @entity1 , comparable to results seen after RYGB surgery. Gut hormone analyses revealed a potential role of fasting @entity6 in early remission of @entity3 2 @entity1 . Interestingly, the DJBL-induced elevation of ghrelin contradicts the suggested role of reduced ghrelin levels after RYGB in improvement of glycemic control.

title: Duodenal-jejunal bypass liner implantation provokes rapid XXXX and improved glycemic control, accompanied by elevated fasting ghrelin levels.

answer: @entity4


abstract: Establishment of @entity5 infective larvae is blocked to a large degree in the immune @entity0 as compared with the nonimmune host. The rapidity with which this response occurs indicates that most worms are either prevented from penetrating the intestinal epithelium or are rejected immediately after cell entry. It is proposed that interference with larval infectivity is due to alterations in the epithelial cell apical or brush border membrane. Alterations may result from prior @entity1 or may reflect an acute change induced by @entity1 . In either case the establishment of normal populations of larvae in the mucosa is disturbed. Lectin binding capacity of brush border membranes was used to assess possible membrane alterations. This parameter in uninfected (control) @entity0 was compared with that in infected @entity0 , which acquire resistance to subsequent challenge, and in infected @entity0 immediately after a challenge inoculum. Enriched brush border membrane preparations were characterized for their binding of @entity3 germ agglutinin, which attaches specifically to the @entity2 , @entity4 . Maximum specific binding of 125I-labeled @entity3 germ agglutinin occurred within 20 min. The spontaneous rate of dissociation was negligible for 90 min. Highest specific binding resulted at 24 degrees C, pH 6.0 and with 75 micrograms brush border membrane protein per assay tube. Results suggested the existence of multiple binding sites. 1 mg of membrane protein from uninfected @entity0 and @entity0 immunized by @entity1 maximally bound 9.8 X 10(10) and 4.3 X 10(10) molecules of @entity3 germ agglutinin, respectively. Binding for the 'immune' brush border membrane, as compared with the 'uninfected' brush border membrane was reduced during the first 3 weeks of @entity1 and remained low for at least 3 months. No further reduction in binding was observed for brush border membrane isolated within minutes after a secondary @entity1 . These results reveal the induction by a @entity1 of changes in brush border membrane structure and the persistence of these changes in the immune host. In view of the rapid turnover time of epithelial tissue the mechanism by which this change is perpetuated speculatively involves immune elements in the lamina propria.

title: Intestinal epithelial membrane changes in @entity0 immune to XXXX .

answer: @entity5


abstract: Establishment of @entity5 infective larvae is blocked to a large degree in the immune @entity0 as compared with the nonimmune host. The rapidity with which this response occurs indicates that most worms are either prevented from penetrating the intestinal epithelium or are rejected immediately after cell entry. It is proposed that interference with larval infectivity is due to alterations in the epithelial cell apical or brush border membrane. Alterations may result from prior @entity1 or may reflect an acute change induced by @entity1 . In either case the establishment of normal populations of larvae in the mucosa is disturbed. Lectin binding capacity of brush border membranes was used to assess possible membrane alterations. This parameter in uninfected (control) @entity0 was compared with that in infected @entity0 , which acquire resistance to subsequent challenge, and in infected @entity0 immediately after a challenge inoculum. Enriched brush border membrane preparations were characterized for their binding of @entity3 germ agglutinin, which attaches specifically to the @entity2 , @entity4 . Maximum specific binding of 125I-labeled @entity3 germ agglutinin occurred within 20 min. The spontaneous rate of dissociation was negligible for 90 min. Highest specific binding resulted at 24 degrees C, pH 6.0 and with 75 micrograms brush border membrane protein per assay tube. Results suggested the existence of multiple binding sites. 1 mg of membrane protein from uninfected @entity0 and @entity0 immunized by @entity1 maximally bound 9.8 X 10(10) and 4.3 X 10(10) molecules of @entity3 germ agglutinin, respectively. Binding for the 'immune' brush border membrane, as compared with the 'uninfected' brush border membrane was reduced during the first 3 weeks of @entity1 and remained low for at least 3 months. No further reduction in binding was observed for brush border membrane isolated within minutes after a secondary @entity1 . These results reveal the induction by a @entity1 of changes in brush border membrane structure and the persistence of these changes in the immune host. In view of the rapid turnover time of epithelial tissue the mechanism by which this change is perpetuated speculatively involves immune elements in the lamina propria.

title: Intestinal epithelial membrane changes in XXXX immune to @entity5 .

answer: @entity0


abstract: PURPOSE: The surgical margin is the main prognostic factor over which the surgeon has control during resection of @entity2 ( @entity2 ). This study examined the association between surgical excision margins of @entity0 with @entity2 and outcomes of disease-free and overall survival. MATERIALS AND METHODS: The authors implemented a retrospective cohort study. The sample was composed of @entity0 with @entity2 having resection as their initial treatment. The predictor variable was the pathologic surgical margin, defined as clear (>5  mm), close (1 to 5  mm), or involved (<1  mm). The outcome variables were disease-free (absence of locoregional recurrence) and overall survival. Data were analyzed using Kaplan-Meier survival curves and @entity1 regression hazard model. RESULTS: The sample was composed of 54 @entity0 with a mean age of 60.5  years (range, 19 to 85  yr) and 26% were @entity0 . The 2- and 5-year overall survival rates were 59 and 50%, respectively. The clear surgical margin group showed higher disease-free survival rates than @entity0 with close and involved margins (5-yr probability, 0.78 vs 0.43 and 0.29; P  = .014) and a trend toward increased overall survival at 2 and 5  years (P  = .093). CONCLUSION: The results suggest that the presence of a close surgical margin (1 to 5  mm) is an adverse risk feature comparable to an involved margin and therefore is associated with decreased disease-free and overall survival. Future studies are needed to replicate these findings before they can be used as a basis for clinical recommendations.

title: How Does the Close Surgical Margin Impact Recurrence and Survival When Treating XXXX ?

answer: @entity2


abstract: KEY MESSAGE: Conditions for the isolation and transfection of @entity2 nucellus protoplasts were established. We demonstrated its utilization for protein expression, localization, protein-protein interaction, and the investigation of @entity0 -related processes. Plant protoplasts are an important and versatile cell system that is widely used in the analysis of gene characterization and diverse signaling pathways. @entity0 ( @entity0 ) occurs throughout the life of plants from embryogenesis to fertilization. The @entity2 nucellus undergoes typical @entity0 during development of the embryo sac. The nucellus protoplast shows potential for use in research of @entity0 -related processes. No studies have reported previously the isolation and transfection of nucellus protoplasts. In this study, conditions for the isolation and transfection of @entity2 nucellus protoplasts were established. The @entity2 protoplast system can be used for protein expression, localization, and protein-protein interaction. We applied this system to investigate @entity0 -related processes. Quantitative real-time PCR analysis revealed that transient expression of @entity3 in the @entity2 nucellus protoplast increases @entity1 -protease gene transcript level. In addition, b-glucuronidase and luciferase activity assays showed that @entity3 could enhance the promoter activities of the @entity1 -protease gene. Thus, we demonstrated the potential of a highly efficient @entity2 nucellus protoplast system for transient gene expression and investigation of @entity0 -related processes.

title: A highly efficient XXXX nucellus protoplast system for transient gene expression and studying programmed cell death-related processes.

answer: @entity2


abstract: @entity3 is a rare @entity1 leading to systemic changes including early and severe @entity2 which affects mobility. For unknown reasons, the onset of degenerative changes is delayed to around 30 years of age when both objective and subjective symptoms develop. In order to complement description of the structural changes in @entity3 with measures of movement function, clinical gait analysis was added to the list of assessments in 2013. The aim of this study was to describe the deviation of gait from normality as a function of age in @entity0 with @entity3 . Three-dimensional movement of reflective markers attached to joints were captured during walking in 39 @entity0 and 10 controls. Subsequent to processing the data to emphasise the shape of marker trajectories, the mean Movement Deviation Profile was generated for all @entity0 . This single number measure gives the deviation of a @entity0 's gait from a distributed definition of gait normality. Results showed that gait deviation roughly follows a sigmoid profile with minimal increase of gait deviations in a younger @entity0 group and an abrupt large increase around the second half of the 4th decade of life. Larger variations of gait deviations were found in the older group than in the younger group suggesting a complex interaction of multiple factors which determine gait function after symptoms manifest. Continued gait analysis of adults with @entity3 , extended to younger adults and @entity0 with @entity3 , is expected to complete understanding of both the natural history of @entity3 and how interventions can affect movement function.

title: Age-Related Deviation of Gait from Normality in XXXX .

answer: @entity3


abstract: BACKGROUND: Cervical nerve root @entity3 after @entity2 is a well-known occurrence. It is associated with traction injuries to the brachial plexus, commonly after high-speed motor vehicle collisions. @entity5 @entity3 occurs when traction forces pull the nerve root sleeve into the intervertebral foramen with associated tearing of the meninges. The proximal nerve root retracts, and the neural foramen fills with cerebrospinal fluid and eventually forms a pseudomeningocele. Although imaging characteristics often include nerve root @entity1 and pseudomeningoceles, there has only been one description of associated @entity8 in the literature. CASE DESCRIPTION: A 3-year-old @entity0 restrained in a passenger-side rear car seat presented to the emergency department after a high-speed motor vehicle collision. The @entity0 was found lying unconscious on the floor of the front passenger side. On arrival, she was flaccid with absent sensation in her left upper extremity, 3/5 strength in her right upper extremity, and full strength in her lower extremities. Computed tomography of the cervical spine was negative for acute @entity4 . Magnetic resonance imaging (MRI) of the cervical spine demonstrated a noncompressive @entity8 from @entity6 and MRI brachial plexus demonstrated diffuse left cervical nerve root @entity1 and @entity6 @entity3 with pseudomeningoceles, which were not seen on the MRI cervical spine. The @entity0 was managed conservatively for her @entity7 . CONCLUSIONS: Although pseudomeningocele formation after cervical nerve root @entity3 is commonly cited, associated @entity8 are not well described. It is important to consider this etiology in @entity0 with asymmetric examinations and @entity8 before surgical evacuation.

title: Posttraumatic Cervical Nerve Root XXXX .

answer: @entity8


abstract: PURPOSE: This paper presents a new cognitive assistive technology, nonlinear contextually aware prompting system (N-CAPS) that uses advanced sensing and artificial intelligence to monitor and provide assistance to workers with @entity1 during a factory assembly task. METHODS: The N-CAPS system was designed through the application of various computer vision and artificial intelligence algorithms that allows the system to track a user during a specific assembly task, and then provide verbal and visual prompts to the worker as needed. A pilot study was completed with the N-CAPS solution in order to investigate whether it was an appropriate intervention. Four @entity0 completed the required assembly task five different times, using the N-CAPS system. RESULTS: The @entity0 completed all of the trials that they attempted with 85.7% of the steps completed without assistance from the job coach. Of the 85.7% of steps completed independently, 32.5% of these were completed in response to prompts given by N-CAPS. Overall system accuracy was 83.3%, the overall sensitivity was 86.2% and the overall specificity was 82.4%. CONCLUSIONS: The results from the study were positive in that they showed that this type of technology does have merit with this population. Implications for Rehabilitation It provides a concise summary of the importance of work in the lives of @entity0 with @entity2 and how technology can support this life goal. It describes the first artificially intelligent system designed to support workers with intellectually disabilities. It provides evidence that individuals with @entity2 can perform a work task in response to technology.

title: A nonlinear contextually aware prompting system (N-CAPS) to assist workers with XXXX to perform factory assembly tasks: system overview and pilot testing.

answer: @entity2


abstract: Case 1 involved a 77-year-old @entity0 admitted to our hospital after he lost almost all memory of work on the day before. Diffusion-weighted imaging (DWI) revealed spotty hyperintensities in the bilateral hippocampi, which were considered responsible for the @entity6 . Transesophageal echocardiography (TEE) showed severe aortic arch @entity4 , 6.8   mm in diameter with extension to the branch. @entity3 to the bilateral hippocampi was diagnosed. Case 2 involved a 66-year-old @entity0 admitted to our hospital because she had lost all memory of the 5 hours she was out. She had transient anterograde @entity6 . DWI revealed no @entity7 , but magnetic resonance angiography (MRA) revealed @entity2 of the right posterior cerebral artery. MRA on hospital day 7 revealed partial recanalization. TEE showed aortic arch @entity4 of 3.9   mm in diameter with extension to the branch. In both cases, aortogenic @entity3 to the hippocampus might have been causally related to transient @entity5 . In @entity0 with acute @entity5 , the possibility of @entity1 should be considered.

title: Two cases of ischemic cerebrovascular disease with only XXXX as neurological symptom and abnormal MR findings.

answer: @entity5


abstract: UNASSIGNED: A 19-year-old @entity0 with @entity7 and @entity6 after strenuous exercise presented to emergency department . On physical examination, the neck and shoulders appeared to be swollen. There was crepitus on @entity3 . Chest X-ray disclosed @entity8 and @entity9 . CT showed additional finding of air in epidural space. The @entity0 was discharged after 2   days of hospitalisation with conservative treatment uneventfully. @entity11 is usually caused by abrupt increase in intrathoracic pressure in instance of forceful @entity4 , cough or @entity5 attack in an otherwise healthy young adult. It is usually accompanied with @entity9 . The management of epidural @entity10 should be tailored according to its primary cause. For most @entity0 with @entity11 associated to a spontaneous @entity9 without @entity1 , this condition is generally self-limited. For epidural free air of large volume that causes @entity2 , surgical laminectomy may be indicated.

title: Teenager with XXXX and swollen neck: a leave-it-alone condition.

answer: @entity6


abstract: Single test stimulation of the ventricle revealed initiation of echoes with a supraventricular QRS complex with a shorter P-R than R-P interval in 28 of 300 @entity0 consecutively studied with programmed electrical stimulation of the heart because of documented or suspected @entity1 . In all 28 the initiation of echoes was related to a discontinuity in the retrograde conduction curve. In 10 @entity0 a different atrial activation sequence in the endocavitary leads was present before and after the discontinuity in the retrograde conduction curve. In five of these a sustained @entity1 with a shorter P-R than R-P interval could be initiated, and in all five @entity0 an accessory pathway with a long conduction time as the retrograde arm of the @entity1 circuit could be demonstrated. In these five @entity0 spontaneous initiation of @entity1 was observed during sinus rhythm or after @entity5 . @entity1 accelerated after the administration of @entity3 . In the remaining 23 @entity0 the initiation of echoes showing a shorter P-R than R-P interval was nonsustained. In these @entity0 spontaneous @entity4 or initiation by @entity5 was not observed, and echoes with this relation of the P-R and R-P intervals systematically disappeared after administration of @entity3 . It is postulated that in these @entity0 a slow atrioventricular (A-V) nodal pathway is used in the retrograde direction during echoes showing a shorter P-R than R-P interval. @entity2 junctional @entity1 showing this relation between P-R and R-P intervals favors incorporation of an accessory pathway with slow retrograde conduction in the @entity1 circuit.

title: Observations in XXXX showing A-V junctional echoes with a shorter P-R than R-P interval.

answer: @entity0


abstract: BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tube placement is recommended in @entity3 ( @entity3 ) @entity0 with @entity5 to provide reliable access for medications and nutrition. It is preferably done while forced vital capacity (FVC) is greater than 50% of predicted to reduce risk of postprocedural @entity6 . Percutaneous radiologic gastrostomy has been shown to have higher success rates and lower complication rates compared with PEG. The authors sought to investigate the safety of PEG placement in @entity3 @entity0 with varying respiratory compromise. METHODS: The records of 21 @entity0 with @entity3 who underwent PEG tube placement from October 2010 to October 2013 were retrospectively reviewed to determine rates of successful placement, complication, mortality and survival. RESULTS: PEG was placed successfully in 95.2% of @entity0 . There was 1 major complication, procedure-related @entity2 , and failed placement in a @entity0 with FVC 15% predicted who developed procedure-related @entity4 and @entity6 and @entity2 8 days after failed PEG attempt. Minor complications included 3 @entity0 with minor @entity1 at insertion site, 1 @entity0 with minor bleeding requiring cauterization and 2 @entity0 requiring PEG tube replacement within 6 months of procedure for accidental dislodgement. After PEG placement, median survival was 327 days (95% confidence interval: 180-687). CONCLUSIONS: In conclusion, PEG tube placement in @entity0 with @entity3 seems to be a safe procedure in @entity0 without significant respiratory compromise. In @entity0 with FVC <50%, based on literature review and the results of this study, the authors recommend percutaneous radiologic gastrostomy over PEG placement.

title: Percutaneous Endoscopic Gastrostomy in XXXX .

answer: @entity3


abstract: The use of barbiturates to induce @entity6 as a means of extending the period of reversible @entity9 is reviewed. @entity12 use in @entity0 who had had @entity3 or were undergoing @entity4 surgery was initially encouraging. In uncontrolled feasibility trials in @entity0 with @entity7 or in deep @entity6 , 40 @entity0 received 10 mg/kg thiopental @entity8 by i.v. push followed by 20 mg/kg thiopental @entity8 i.v. over the next 30 minutes; 60% of these @entity0 regained consciousness. In a subgroup of 22 @entity0 who had @entity2 normally associated with a 90% mortality rate, 14 recovered completely. In the largest clinical trial, 45 @entity0 with severe @entity5 and elevated intracranial pressure received 3--5 mg/kg @entity10 over 10--20 minutes. A serum @entity12 level of 2.5--4.0 mg/dl was maintained for 14 days, and 30% of these @entity0 recovered but with @entity1 . Other results in @entity3 and drowning victims were not as encouraging. It is concluded that @entity12 therapy is beneficial in the lowering of intracranial pressure. Focal and global @entity9 have been shown amenable to @entity12 therapy in isolated cases. The prophylactic use of barbiturates in surgical procedures requiring focal @entity11 appears to be beneficial. Controlled trials of the use of @entity12 -induced @entity6 are clearly indicated.

title: @entity12 -induced @entity6 to protect against XXXX and increased intracranial pressure.

answer: @entity9


abstract: The use of barbiturates to induce @entity6 as a means of extending the period of reversible @entity9 is reviewed. @entity12 use in @entity0 who had had @entity3 or were undergoing @entity4 surgery was initially encouraging. In uncontrolled feasibility trials in @entity0 with @entity7 or in deep @entity6 , 40 @entity0 received 10 mg/kg thiopental @entity8 by i.v. push followed by 20 mg/kg thiopental @entity8 i.v. over the next 30 minutes; 60% of these @entity0 regained consciousness. In a subgroup of 22 @entity0 who had @entity2 normally associated with a 90% mortality rate, 14 recovered completely. In the largest clinical trial, 45 @entity0 with severe @entity5 and elevated intracranial pressure received 3--5 mg/kg @entity10 over 10--20 minutes. A serum @entity12 level of 2.5--4.0 mg/dl was maintained for 14 days, and 30% of these @entity0 recovered but with @entity1 . Other results in @entity3 and drowning victims were not as encouraging. It is concluded that @entity12 therapy is beneficial in the lowering of intracranial pressure. Focal and global @entity9 have been shown amenable to @entity12 therapy in isolated cases. The prophylactic use of barbiturates in surgical procedures requiring focal @entity11 appears to be beneficial. Controlled trials of the use of @entity12 -induced @entity6 are clearly indicated.

title: XXXX -induced @entity6 to protect against @entity9 and increased intracranial pressure.

answer: @entity12


abstract: The use of barbiturates to induce @entity6 as a means of extending the period of reversible @entity9 is reviewed. @entity12 use in @entity0 who had had @entity3 or were undergoing @entity4 surgery was initially encouraging. In uncontrolled feasibility trials in @entity0 with @entity7 or in deep @entity6 , 40 @entity0 received 10 mg/kg thiopental @entity8 by i.v. push followed by 20 mg/kg thiopental @entity8 i.v. over the next 30 minutes; 60% of these @entity0 regained consciousness. In a subgroup of 22 @entity0 who had @entity2 normally associated with a 90% mortality rate, 14 recovered completely. In the largest clinical trial, 45 @entity0 with severe @entity5 and elevated intracranial pressure received 3--5 mg/kg @entity10 over 10--20 minutes. A serum @entity12 level of 2.5--4.0 mg/dl was maintained for 14 days, and 30% of these @entity0 recovered but with @entity1 . Other results in @entity3 and drowning victims were not as encouraging. It is concluded that @entity12 therapy is beneficial in the lowering of intracranial pressure. Focal and global @entity9 have been shown amenable to @entity12 therapy in isolated cases. The prophylactic use of barbiturates in surgical procedures requiring focal @entity11 appears to be beneficial. Controlled trials of the use of @entity12 -induced @entity6 are clearly indicated.

title: @entity12 -induced XXXX to protect against @entity9 and increased intracranial pressure.

answer: @entity6


abstract: UNASSIGNED: Background and study aims: The clinical utility of computed virtual chromoendoscopy with flexible spectral imaging color enhancement (FICE) in capsule endoscopy (CE) remains controversial. To clarify the clinical utility of FICE-enhanced CE in evaluating @entity2 , we quantitatively assessed white light (WL), FICE, and blue mode (BM) images and examined the sensitivity of these 3 imaging modes of small-bowel lesions from @entity0 who underwent CE. Methods: The CIELAB color difference (   E) and visual analogue scales (VAS) were measured in 261CE images (3 different lesion categories) using WL and FICE set 1, 2, and 3, and BM images, respectively. Three endoscopists reviewed CE videos with WL, 3 FICE mode settings, and BM, and compared the sensitivity and detectability for small intestinal diseases from 50 @entity0 who underwent CE. Results: In the assessment of visibility in the 152 vascular lesion images, the    E and VAS of FICE set 1, 2, and BM images were significantly higher than that of WL images. In 88 @entity5 /ulceration images, the    E and VAS of FICE set 1 and 2 images were significantly higher than that of WL images. In 21 @entity1 images, there were no significant differences in    E among these modalities. When analyzed on a per- @entity0 basis, FICE settings 1 and 2 had the highest sensitivity (100%) and specificity (97.3-100%) for @entity3 . As for erosive/ulcerative lesions, FICE setting 2 had the highest sensitivity (100%) and specificity (97.2%). For @entity1 or @entity4 , WL had the highest sensitivity (90.9%) and specificity (87.1%). In per-lesion analysis, FICE settings 1 and 2 showed significantly superior detection ability over WL for @entity3 . In the detection of erosive/ulcerative lesions, FICE setting 2 was significantly superior to WL. In @entity1 images, there was no significant improvement with any of the settings relative to WL images. Conclusions: FICE is most useful for improving CE image quality and detection in cases of angioectasia and @entity5 /ulceration of the small intestine.

title: Clinical utility of capsule endoscopy with flexible spectral imaging color enhancement for diagnosis of XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity1 repair (EVAR) is a comparatively less invasive technique than open repair (OR). Debate remains with regard to the benefit of EVAR for @entity0 with @entity2 ( @entity2 ). We sought to evaluate and report outcomes of EVAR for @entity2 in an Irish tertiary vascular referral centre. METHODS: @entity0 undergoing emergency surgery for ruptured or symptomatic @entity3 were identified from theatre logbooks and HIPE database. Retrospective chart review was undertaken. Data were exported to IBM SPSS version 21 for statistical analysis with p  <  0.05 considered significant. RESULTS: A total of 41 @entity0 underwent surgery for @entity2 . The mean age was 74 years old with a range from 55 to 89 years. The majority (n  =  25, 61%) were baseline American Society of Anaesthesiology (ASA) grade 3-4. Of these 56% underwent EVAR with the remaining 44% repaired open. Mortality rate in those undergoing emergency EVAR was 34.8%, compared with 38.9% in those undergoing open surgery. This difference was not statistically significant. The mean overall length of stay was 13 days. With regard to prognostic indicators of @entity0 outcome, increasing @entity0 age was noted to be significantly associated with increased mortality (p  =  0.013), as was increased ASA score at time of surgery (p  =  0.029). CONCLUSIONS: Mortality rates in those undergoing EVAR for @entity2 are comparable with those undergoing open repair. Increasing age and ASA score are significant predictors of mortality in @entity0 with @entity2 undergoing intervention.

title: Endovascular versus open repair of XXXX .

answer: @entity2


abstract: BACKGROUND: Negative pressure wound therapy (NPWT) is a widely accepted method of temporary coverage for complex lower extremity wounds before definitive reconstruction. However, the precise role of NPWT in the perioperative management of @entity0 with complicated lower @entity1 remains unclear. In this study, we examine the effect of NPWT on flap complications and overall outcomes based on timing of soft-tissue reconstruction relative to @entity1 . METHODS: We retrospectively reviewed the medical records of 32 consecutive @entity0 presenting to a single institution receiving lower extremity reconstruction after Gustilo class IIIB or IIIC open @entity2 over a 5-y period. Length of hospitalization, number of surgical procedures, flap failure, infection, and nonunion were parameters of interest in this study. RESULTS: The incidence of complications in @entity0 treated with NPWT was lower compared with @entity0 who underwent wet-to-dry dressing changes, regardless of when surgery was performed. The highest rate of complications was observed in @entity0 operated on >6  wk after injury and who received wet-to-dry dressing changes wound care. By comparison, those who underwent surgery within 1  wk of injury and who were bridged with NPWT had the lowest rate of complications. CONCLUSIONS: The use of NPWT therapy in the perioperative management of @entity0 with open lower extremity @entity2 reduces complication rates associated with limb salvage surgery. Our results suggest that NPWT can be used as a temporizing measure to optimize @entity0 before flap surgery, effectively lengthening the window of opportunity for definitive reconstruction.

title: The use of negative pressure wound therapy in severe open lower extremity XXXX : identifying the association between length of therapy and surgical outcomes.

answer: @entity2


abstract: @entity1 chronotherapy aims at enhancing tolerability and efficacy of anticancer drugs through their delivery according to circadian clocks. However, @entity3 and @entity0 data show that lifestyle, sex, genetics, drugs, and @entity1 can modify both host circadian clocks and metabolism pathways dynamics, and thus the optimal timing of drug administration. The mathematical modeling of chronopharmacology could indeed help moderate optimal timing according to @entity0 -specific determinants. Here, we combine in vitro and in silico methods, in order to characterize the critical molecular pathways that drive the chronopharmacology of @entity5 , a topoisomerase I inhibitor with complex metabolism and known activity against @entity2 . Large transcription rhythms moderated drug bioactivation, detoxification, transport, and target in synchronized @entity2 . These molecular rhythms translated into statistically significant changes in pharmacokinetics and pharmacodynamics according to in vitro circadian drug timing. The top-up of the multiple coordinated chronopharmacology pathways resulted in a four-fold difference in @entity5 -induced apoptosis according to drug timing. @entity5 @entity4 was directly linked to clock gene @entity6 expression: The least apoptosis resulted from drug exposure near @entity6 mRNA nadir (P < 0.001), whereas clock silencing through siBMAL1 exposure ablated all the chronopharmacology mechanisms. Mathematical modeling highlighted circadian bioactivation and detoxification as the most critical determinants of @entity5 chronopharmacology. In vitro-in silico systems chronopharmacology is a new powerful methodology for identifying the main mechanisms at work in order to optimize circadian drug delivery.

title: Identification of Circadian Determinants of XXXX Chronotherapy through In Vitro Chronopharmacology and Mathematical Modeling.

answer: @entity1


abstract: OBJECTIVES: In @entity0 , @entity2 type 1 and 2 receptors ( @entity3 and AT2R) have been implicated in trophoblast invasion and placental development. Since the utero-placental unit of @entity1 (GP) and @entity0 share a morphologic structure, hormonal, vasodilator patterns and uterine spiral artery remodeling, this species was deemed suitable to study the spatio-temporal expression of the vasoconstrictive ( @entity3 ) and vasodilator (AT2R) receptors of @entity2 . METHODS: Utero-placental units were collected in days (D) 15, 20, 40 and 60 of a 64-67days long pregnancy in Pirbright White @entity1 (n=3 per period). The localization and intensity of expression of @entity3 and AT2R in different structures of utero-placental units was evaluated by immunohistochemistry. Additionally immunogold electron microscopy for both receptors was performed in day 60. RESULTS: @entity3 and AT2R were detected along pregnancy in the interlobium, the endothelium and syncytiotrophoblast of the placental labyrinth, subplacenta, giant cells, syncytial streamers, decidua, vascular smooth muscle of spiral arteries and myometrium; in day 20 in perivascular and intramural trophoblasts, while in late pregnancy these were observed in endoluminal trophoblasts in lateral and myometrial spiral arteries. The immunoreactivity of @entity3 and AT2R was prominent in D15 in syncytial streamers and in D40 in intramural and intraluminal trophoblasts. Immunoelectron microscopy in D60 demonstrated both receptors in cell membrane, cytosol (cyt) and nucleus (nu) in the placenta (Figure). CONCLUSIONS: The spatial pattern of @entity3 and AT2R supports their association with decidualization, trophoblast invasion, vascular remodeling. This similarity with the @entity0 , added to an analogous intracellular localization of @entity3 , validates the use of @entity1 to understand the local adaptations of pregnancy. Supported by Fondecyt 1121161 DISCLOSURES: S. Acuna: None. G. Valdes: None.

title: [107-POS] : Cellular and subcellular localization of angiotensin AT1 and AT2 receptors in XXXX utero-placental units along pregnancy.

answer: @entity1


abstract: OBJECTIVES: @entity0 who experienced @entity2 pregnancy need life-long follow up of blood pressure, due to the higher risk of later @entity1 . However, routine visit for practitioner is sometimes difficult for postpartum mothers because of her lifestyle or the distance to doctors. In this study, we investigated the usability of mobile sphygmomanometer for follow up of @entity2 pregnancy. METHODS: One multi-para pregnant subject complicated with @entity3 (#1) and other multi-para who experienced severe @entity4 and @entity5 at 32 weeks' gestation in former pregnancy (#2) were recruited to the trial of use web-linked sphygmomanometer (HEM-7251G with MedLINK system, Omron, Japan). Next, two mild @entity2 @entity0 who successfully given birth (#3, who experienced @entity5 in former pregnancy; #4 without medication) who moved to the distant area (100 km and 500 km from our hospital) were recruited for the trial for 6 months with informed consent. Blood pressure data were automatically sent twice a day after their measurement. The data were gathered, analyzed and seen on a secured website. RESULTS: All @entity0 completed their measurement twice a day without any technical problem. The @entity0 #1 had a normal spontaneous delivery and #2 is now planned for cesarean section with no complications. Average systolic blood pressure of the @entity0 #3 was 135  11mmHg at morning and 136   12 at evening, and of #4 was 135  11 and 140  12. No @entity2 emergency was observed in all @entity0 . CONCLUSIONS: The compliance of the @entity0 for the routine measurement of their blood pressure was notably good and produced good check-up of their health condition, both in pregnancy and on postpartum period in the distant area. A problem to be solved is corroboration with regional emergency care system when the @entity0 experienced the @entity2 emergency. DISCLOSURES: S. Onishi: None. K. Nakano: None. K. Iwai: None. Y. Yamada: None. J. Akasaka: None. A. Shigemitsu: None. K. Naruse: None. H. Kobayashi: None.

title: [165-POS] : Postpartum follow-up of XXXX pregnancy using at-home web-linked mobile sphygmomanometer.

answer: @entity2


abstract: This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5  min) in @entity0 with @entity3 , @entity4 , and @entity5 ( @entity5 ). Twenty-six @entity0 with 29 lesions (4 @entity3 , 13 high-grade @entity3 , 7 @entity1 , and 5 @entity5 ) underwent DCE-MRI in a 3  T scanner. A ROI was placed on the hotspot of each @entity2 in maps for volume transfer contrast K (trans) , extravascular extracellular volume V e , and fractional plasma volume V p . We analyzed differences in parameters between @entity2 using the Mann-Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis. Mean K (trans) values of LGG, HGG, @entity1 and @entity5 were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each @entity2 was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each @entity2 was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other @entity2 types, @entity3 showed lower K (trans) (P   <   0.01, sensitivity   =   88%, specificity   =   100%) and lower V e (P   <   0.01, sensitivity   =   96%, specificity   =   100%). @entity5 showed higher V e (P   <   0.01, sensitivity   =   100%, specificity   =   88%), but the other perfusion parameters overlapped with those of different histology. Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of @entity6 .

title: Diagnosis of XXXX using dynamic contrast-enhanced perfusion imaging with a short acquisition time.

answer: @entity6


abstract: Background. Triweekly @entity5 -based postoperative concurrent chemoradiotherapy (CCRT) has high intolerance and @entity4 in locally advanced @entity3 (LAHNC). We evaluated the effect of a modified weekly @entity5 -based chemotherapy in postoperative CCRT. Methods. A total of 117 @entity0 with LAHNC were enrolled between December 2007 and December 2012. Survival, compliance/adverse events, and independent prognostic factors were analyzed. Results. Median follow-up time was 30.0 (3.1-73.0) months. Most @entity0 completed the entire course of postoperative CCRT (radiotherapy >=  60   Gy, 94.9%; >= 6 times weekly chemotherapy, 75.2%). Only 17.1% @entity0 required hospital admission. The most common adverse effect was grade 3/4 @entity2 (28.2%). No @entity0 died due to protocol-related adverse effects. Multivariate analysis revealed the following independent prognostic factors: @entity1 , extracapsular spread, and total radiation dose. Two-year progression-free survival and overall survival rates were 70.9% and 79.5%, respectively. Conclusion. Modified weekly @entity5 -based chemotherapy is an acceptable regimen in postoperative CCRT for LAHNC.

title: Modified weekly XXXX -based chemotherapy is acceptable in postoperative concurrent chemoradiotherapy for locally advanced @entity3 .

answer: @entity5


abstract: Background. Triweekly @entity5 -based postoperative concurrent chemoradiotherapy (CCRT) has high intolerance and @entity4 in locally advanced @entity3 (LAHNC). We evaluated the effect of a modified weekly @entity5 -based chemotherapy in postoperative CCRT. Methods. A total of 117 @entity0 with LAHNC were enrolled between December 2007 and December 2012. Survival, compliance/adverse events, and independent prognostic factors were analyzed. Results. Median follow-up time was 30.0 (3.1-73.0) months. Most @entity0 completed the entire course of postoperative CCRT (radiotherapy >=  60   Gy, 94.9%; >= 6 times weekly chemotherapy, 75.2%). Only 17.1% @entity0 required hospital admission. The most common adverse effect was grade 3/4 @entity2 (28.2%). No @entity0 died due to protocol-related adverse effects. Multivariate analysis revealed the following independent prognostic factors: @entity1 , extracapsular spread, and total radiation dose. Two-year progression-free survival and overall survival rates were 70.9% and 79.5%, respectively. Conclusion. Modified weekly @entity5 -based chemotherapy is an acceptable regimen in postoperative CCRT for LAHNC.

title: Modified weekly @entity5 -based chemotherapy is acceptable in postoperative concurrent chemoradiotherapy for locally advanced XXXX .

answer: @entity3


abstract: The purification of the various types of cells in solid @entity0 is necessary for study of their biochemical and immunological functions. The R3230AC @entity2 contains both a variety of stromal cells and well-differentiated neoplastic cells that possess many of the biosynthetic capabilities of normal @entity1 mammary cells. Suspensions of cells from @entity0 weighing less than 1.2 g consisted of 70.4 +/- 7.2% (S.D.) malignant cells by morphology, 6.8 +/- 3.0% lymphocytes, 6.3 +/- 3.2% macrophages, 15.2 +/- 5.2% red blood cells, 0.8 +/- 0.5% granulocytes, and 0.5 +/- 0.6% unidentified cells. Sedimentation of the cells from the R3230AC @entity0 in a previously described isokinetic gradient resulted in a 5- to 6-fold purification of lymphocytes and macrophages. The modal fraction of malignant cells contained 95.3 +/- 2.9% malignant cells. Detection of alpha-lactalbumin by the direct peroxidase conjugate technique gave vacuolar staining of malignant cells, in contrast to the indirect and peroxidase-antiperoxidase techniques which stained ducts from normal lactating mammary gland and a wide variety of cells without vacuoles in the @entity0 . The best fixative for frozen sections, paraffin-embedded tissue, and cell suspensions was 50% @entity3 -50% @entity4 . The suspensions of @entity0 cells contained 14.4 +/- 9.4% cells with histochemically demonstrable alpha-lactalbumin. Squamous metaplasia was commonly observed in @entity0 than lactating @entity1 .

title: Separation and characterization of the neoplastic and stromal elements of the R3230AC mammary XXXX .

answer: @entity2


abstract: UNASSIGNED: Literature comparing 'jumping to conclusions' (JTC) between @entity0 and healthy controls has demonstrated the importance of the reasoning bias in the development of delusions. When groups that vary along the entire delusional continuum are included, the relationship between JTC and delusionality is less clear. This study compared JTC and delusional dimensions between 28 @entity0 with delusions, 35 delusion-prone individuals and 32 non-delusion-prone individuals. Delusion proneness was defined by an established threshold based on the Peters et al. @entity1 Inventory. Two versions of the beads task (85:15 and 60:40) were used to measure JTC. As hypothesized, @entity0 manifested hastier data gathering than the two non-clinical groups on both beads tasks. However, delusion-prone individuals did not manifest a hastier decision making style than non-delusion prone individuals. Instead, non-delusion-prone @entity0 showed more JTC bias than delusion-prone individuals on the easier beads task. There was no evidence for a dose-response relationship between JTC and delusional dimensions, with correlations between JTC and PDI scores found in the non-delusion-prone group only. The present finding confirms the link between an extreme JTC bias and the presence of clinical delusions, and argues against a linear relationship between JTC and delusionality along the symptomatic continuum.

title: Jumping to Conclusions Style along the Continuum of XXXX : Delusion-Prone Individuals Are Not Hastier in Decision Making than Healthy Individuals.

answer: @entity1


abstract: OBJECTIVE: The purpose of this article is to determine whether MRI features of @entity3 ( @entity3 ), such as enhancing solid component and T1 signal intensity, are associated with clinicopathologic outcomes. MATERIALS AND METHODS: This retrospective study included 241 RCCs in 230 @entity0 who underwent preoperative MRI, had pathologic analysis results available, and were monitored for at least 3 months. A radiologist assessed @entity2 features on MRI, including unenhanced T1 signal relative to renal cortex and the percentage of solid enhancing components. The electronic medical record or follow-up images were reviewed to assess for the development of local recurrence or @entity1 . Statistical analysis was performed to correlate imaging features at MRI with pathologic and clinical outcome. RESULTS: The following @entity2 features were observed: predominantly cystic morphologic features (defined as solid component  <= 25%, n = 33), solid component greater than 25% (n = 208), T1 hypointensity (n = 97), and T1 intermediate intensity or hyperintensity (n = 144). Local recurrence or @entity1 were observed in 14 @entity0 . Compared with T1-intermediate or -hyperintense lesions, T1-hypointense RCCs were more likely to be low stage (90.7% vs 74.3%; p = 0.001) and low grade (78.9% vs 41.8%; p < 0.001) and had a lower rate of recurrence or @entity1 (3.3% vs 8%; p = 0.167). Compared with lesions with greater than 25% solid enhancement, predominantly cystic RCCs were more likely to be lower stage (93.9% vs 78.8%; p = 0.053) and lower grade (94.7 vs 56.5%; p < 0.001) and to have no incidence of recurrence or @entity1 (0% vs 6.9%; p = 0.227). RCCs that were both cystic and T1 hypointense (n = 14) were lower stage (100% vs 79.6%; p = 0.047) and lower grade (92.9% vs 58.1%; p = 0.01) and had no recurrence or @entity1 on follow-up. CONCLUSION: Cystic and T1-hypointense @entity3 show less-aggressive pathologic features and favorable clinical behavior.

title: MRI Features of XXXX That Predict Favorable Clinicopathologic Outcomes.

answer: @entity3


abstract: OBJECTIVES: The aim of this study was to describe the role of contrast-enhanced cardiac magnetic resonance (CMR) in the workup of @entity0 with @entity6 ( @entity6 ) and in the prediction of long-term outcomes. BACKGROUND: @entity2 is a key substrate for @entity6 , and late @entity9 enhancement (LGE) on a CMR study is a robust technique for imaging of @entity2 . METHODS: We performed a retrospective review of all survivors of @entity6 who were referred for CMR studies and performed follow-up for the subsequent occurrence of an adverse event ( @entity1 and appropriate defibrillator therapy). RESULTS: After a workup that included a clinical history, electrocardiogram, echocardiography, and coronary angiogram, 137 @entity0 underwent CMR for workup of @entity6 (66% male; mean age 56    11 years; left ventricular ejection  fraction 43    12%). The presenting @entity4 were @entity8 (n  = 105 [77%]) and @entity7 (n  = 32 [23%]). Overall, LGE was found in 98 @entity0 (71%), with an average extent of 9.9    5% of the left ventricular myocardium. CMR imaging provided a diagnosis or an arrhythmic substrate in 104 @entity0 (76%), including the presence of an infarct-pattern LGE in 60 @entity0 (44%), noninfarct LGE in 21 (15%), active @entity10 in 14 (10%), @entity5 in 3 (2%), @entity3 in 3, and arrhythmogenic @entity2 in 3. In a median follow-up of 29 months (range 18 to 43 months), there were 63 events. In a multivariable analysis, the strongest predictors of recurrent events were the presence of LGE (adjusted hazard ratio: 6.7; 95% CI: 2.38 to 18.85; p  < 0.001) and the extent of LGE (hazard ratio: 1.15; 95% CI: 1.11 to 1.19; p  < 0.001). CONCLUSIONS: Among @entity0 with @entity6 , CMR with contrast identified LGE in 71% and provided a potential arrhythmic  substrate in 76%. In follow-up, both the presence and extent of LGE identified a group at markedly increased risk of future adverse events.

title: Late XXXX enhancement among survivors of @entity6 .

answer: @entity9


abstract: OBJECTIVES: The aim of this study was to describe the role of contrast-enhanced cardiac magnetic resonance (CMR) in the workup of @entity0 with @entity6 ( @entity6 ) and in the prediction of long-term outcomes. BACKGROUND: @entity2 is a key substrate for @entity6 , and late @entity9 enhancement (LGE) on a CMR study is a robust technique for imaging of @entity2 . METHODS: We performed a retrospective review of all survivors of @entity6 who were referred for CMR studies and performed follow-up for the subsequent occurrence of an adverse event ( @entity1 and appropriate defibrillator therapy). RESULTS: After a workup that included a clinical history, electrocardiogram, echocardiography, and coronary angiogram, 137 @entity0 underwent CMR for workup of @entity6 (66% male; mean age 56    11 years; left ventricular ejection  fraction 43    12%). The presenting @entity4 were @entity8 (n  = 105 [77%]) and @entity7 (n  = 32 [23%]). Overall, LGE was found in 98 @entity0 (71%), with an average extent of 9.9    5% of the left ventricular myocardium. CMR imaging provided a diagnosis or an arrhythmic substrate in 104 @entity0 (76%), including the presence of an infarct-pattern LGE in 60 @entity0 (44%), noninfarct LGE in 21 (15%), active @entity10 in 14 (10%), @entity5 in 3 (2%), @entity3 in 3, and arrhythmogenic @entity2 in 3. In a median follow-up of 29 months (range 18 to 43 months), there were 63 events. In a multivariable analysis, the strongest predictors of recurrent events were the presence of LGE (adjusted hazard ratio: 6.7; 95% CI: 2.38 to 18.85; p  < 0.001) and the extent of LGE (hazard ratio: 1.15; 95% CI: 1.11 to 1.19; p  < 0.001). CONCLUSIONS: Among @entity0 with @entity6 , CMR with contrast identified LGE in 71% and provided a potential arrhythmic  substrate in 76%. In follow-up, both the presence and extent of LGE identified a group at markedly increased risk of future adverse events.

title: Late @entity9 enhancement among survivors of XXXX .

answer: @entity6


abstract: BACKGROUND: Fracture of the hip (HF) is a significant cause of morbidity and mortality in elderly individuals. HF is an acute stress that triggers a state of @entity1 which may affect immune responses and physical recovery. METHODS: Longitudinal study of the impact of HF on the functions of polymorphonuclear neutrophils (PMNs) in elderly subjects. Data were recorded prior to surgery, 6weeks and 6months later. RESULTS: PMN functions were severely impaired shortly after HF ( @entity14 , phagocytosis, @entity4 production) but there was a time-related recovery of some PMN functions ( @entity14 , phagocytosis) over time, except in the case of @entity4 production. Whereas FcyRII ( @entity3 ) expression remained unchanged, FcyRIII ( @entity13 ) increased from low values before surgery to levels of controls 6months post-surgery. This was also the case for the C5a complement receptor and @entity15 . @entity11 and @entity12 expressions were unchanged. Cytokine and chemokine secretions by stimulated PMN were altered. @entity5 and @entity7 secretions were increased following HF but @entity6 secretion was decreased. @entity2 prior to surgery were related to alterations in PI3K and NF-kB signaling pathways. Recovery of these functions paralleled increased PI3K activity, although @entity4 production remained low. Sustained activation of the NF-kB pathway by @entity5 has been reported to involve upregulation of IKKb kinase activity. Activated IKKb kinase inhibits @entity10 and results in concomitant downstream inhibition of @entity8 oxidase complex which can account for sustained impaired production of ROS in HF @entity0 . CONCLUSION: Our data showed that the stress caused by HF negatively affects initial PMN responses shortly after the event and that may negatively influence clinical outcomes such as resolving long-term @entity1 and recovery, as well as explaining susceptibility to @entity9 .

title: Altered neutrophil functions in elderly XXXX during a 6-month follow-up period after a hip fracture.

answer: @entity0


abstract: @entity4 have been shown to contain a population of @entity1 stem cells (CSCs) that present self-renewing capacity and support @entity1 growth and @entity0 . CSCs were shown to secrete large amount of extracellular vesicles (EVs) that can transfer several molecules (proteins, lipids and nucleic acids) and induce epigenetic changes in target cells. Mesenchymal Stromal Cells (MSCs) are susceptible to @entity1 signalling and can be recruited to @entity1 regions. The precise role of MSCs in @entity1 development is still under debate since both pro- and anti-tumorigenic effects have been reported. In this study we analysed the participation of renal CSC-derived EVs in the interaction between @entity1 and MSCs. We found that CSC-derived EVs promoted persistent phenotypical changes in MSCs characterized by an increased expression of genes associated with cell migration ( @entity2 , @entity7 ), matrix remodeling ( @entity8 ), angiogenesis and @entity1 growth ( @entity3 , @entity5 and @entity6 ). EV-stimulated MSCs exhibited in vitro an enhancement of migration toward the @entity1 conditioned medium. Moreover, EV-stimulated MSCs enhanced migration of @entity4 cells and induced vessel-like formation. In vivo, EV-stimulated MSCs supported @entity1 development and vascularization, when co-injected with @entity4 cells. In conclusion, CSC-derived EVs induced phenotypical changes in MSCs that are associated with @entity1 growth.

title: Extracellular vesicles derived from XXXX stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells.

answer: @entity4


abstract: OBJECTIVES: @entity0 reported outcomes (PROs) are relevant in rheumatology. Variable accessibility and validity of commonly used PROs are obstacles to homogeneity in evidence synthesis. The objective of this project was to provide a comprehensive library of "validated PROs". METHODS: A launch meeting with rheumatologists, PROs methodological experts, and @entity0 , was held to define the library's aims and scope, and basic requirements. To feed the library we performed systematic reviews on selected diseases and domains. Relevant information on PROs was collected using standardised data collection forms based on the COSMIN checklist. RESULTS: The EULAR Outcomes Measures Library (OML), whose aims are to provide and to advise on PROs on a user-friendly manner albeit based on scientific grounds, has been launched and made accessible to all. PROs currently included cover any domain and, are generic or specifically target to the following diseases: @entity5 , @entity6 , @entity9 , @entity8 , @entity7 , @entity3 , @entity2 , @entity10 , and @entity4 . Up to 236 instruments (106 generic and 130 specific) have been identified, evaluated, and included. The systematic review for @entity7 , which yielded 10 specific instruments, is presented here as an example. The OML website includes, for each PRO, information on the construct being measured and the extent of validation, recommendations for use, and available versions; it also contains a glossary on common validation terms. CONCLUSIONS: The OML is an in progress library led by rheumatologists, related professionals and @entity0 , that will help to better understand and apply @entity1 .

title: The EULAR Outcome Measures Library: development and an example from a systematic review for XXXX instruments.

answer: @entity7


abstract: Purpose: @entity3 following primary surgery is frequently indicated in @entity0 with @entity2 . The aim of this study is to evaluate the role of an MRI-based strategy in avoiding trimodality therapy. Materials and Methods: We retrospectively reviewed all @entity0 with @entity2 treated initially with primary surgery at Seoul National University Hospital. We suggest an alternative triage strategy in which the primary treatment modality is determined based on preoperative MRI findings. Using this strategy, primary surgery is only indicated when there is no evidence of parametrial involvement (PMI) and lymph node @entity1 (LNM) in the MRI results; when there is evidence of either or both of these factors, primary chemoradiation is selected. Assuming that this strategy is applied to our cohort, we evaluate how the rate of trimodality therapy is affected. Results: Of the 254 @entity0 in our sample, 77 (30.3%) had at least one Category 1 risk factor (PMI, LNM, positive resection margin) upon pathologic examination. If the MRI-based strategy had been applied to our cohort, 168 @entity0 would have undergone primary surgery and 86 would have undergone primary chemoradiation. Only 25 @entity0 (9.8%) would have required trimodality therapy based on an indication of at least one Category 1 pathologic risk factor following radical hysterectomy. Conclusion: The inclusion of MRI in the decision-making process for primary treatment modality could have reduced the number of @entity0 requiring trimodality therapy based on the indication of a Category 1 risk factor from 30.3% to 9.8% in our cohort.

title: An Alternative Triage Strategy Based on Preoperative MRI for Avoiding Trimodality Therapy in Stage IB Cervical XXXX .

answer: @entity2


abstract: BACKGROUND: Brain dead organ donors have altered central hemodynamic performance, impaired hormone physiology, exaggerated systemic inflammatory response, end-organ microcirculatory dysfunction, and tissue @entity2 . A new treatment, @entity1 ( @entity1 ), stabilizes vital organ blood flow after conventionally resuscitated shock to improve these derangements. STUDY DESIGN: A prospective case-control study of adjunctive @entity1 compared 26 experimental @entity0 (brain dead organ donors) to 52 controls (protocolized conventionally resuscitated donors). Actual organ procurement rates were compared with the Scientific Registry of Transplant Recipient predicted organ yield per @entity0 . Achievement of donor management goals and effective hepatic blood flow were recorded. RESULTS: Fourteen of 26 (53.8%) @entity0 treated with @entity1 achieved all donor management goals compared with 17 of 52 (32.7%) @entity0 treated with conventionally resuscitated (odds ratio  = 2.4; 95% CI, 0.92-6.3; p  = 0.06). @entity0 treated with @entity1 were more than 2 times as likely to achieve final @entity3 >100 on 40% FiO2 compared with controls (odds ratio  = 2.8; 95% CI, 1-7.69; p  = 0.03). Also, @entity1 -treated @entity0 required less IV crystalloid during the first 12 hours of management ( @entity1 : 3,167    1,893 mL vs 4,154    2,100 mL; p  = 0.046) and required less vasopressor agents at 12 hours post resuscitation (odds ratio  = 7.7; 95% CI, 0.82-42; p  = 0.02). Direct peritoneal resuscitation @entity0 had enhanced effective hepatic blood flow and significantly higher organs transplanted per donor rates compared with controls (3.7    1.7 vs 3.1    1.3; p  = 0.024). CONCLUSIONS: Direct peritoneal resuscitation reduced IV fluid requirement and IV pressor use as well as increased hepatic blood flow and organs transplanted per donor. Direct peritoneal resuscitation studies show it to be a safe, effective method to augment organ donor resuscitation and additional large-scale trials should be conducted to validate these findings.

title: Addition of direct peritoneal lavage to XXXX cadaver organ donor resuscitation improves organ procurement.

answer: @entity0


abstract: UNASSIGNED: Our objective was to conduct a systematic review and meta-analysis of studies assessing the diagnostic performance of @entity1 standardized uptake value (SUV) in @entity2 ( @entity2 ), as measured by positron emission tomography. A systematic search of the indexed medical literature was conducted using appropriate keywords to identify relevant studies. Six articles were identified by searching electronic databases. A statistical analysis was performed with RevMan 4.2.2 software. SUV measurement and the SUV threshold for defining high SUV were studied dependently. For each publication, we first obtained an estimate of the relative risk (RR) for comparing @entity0 with a low and those with a high SUV. Subsequently, we aggregated the individual RRs into a combined RR using the fixed-effects model to yield weighted mean pooled estimates with 95% confidence intervals (CIs). Publication bias was assessed with a funnel plot. A total of 6 clinical trials involving 453 @entity0 were included in the meta-analysis. The combined RR from the 6 reports for local control was 0.72 (95% CI: 0.63-0.81). The funnel plot revealed symmetrical distribution, indicating no evidence of significant publication bias. The increase in the SUV of the @entity1 was found to be a poor prognostic marker for @entity0 with @entity2 in the meta-analysis, which requires further confirmation in a meta-analysis based on individual @entity0 data.

title: @entity1 standardized uptake value as a prognostic factor in primary XXXX .

answer: @entity2


abstract: UNASSIGNED: Our objective was to conduct a systematic review and meta-analysis of studies assessing the diagnostic performance of @entity1 standardized uptake value (SUV) in @entity2 ( @entity2 ), as measured by positron emission tomography. A systematic search of the indexed medical literature was conducted using appropriate keywords to identify relevant studies. Six articles were identified by searching electronic databases. A statistical analysis was performed with RevMan 4.2.2 software. SUV measurement and the SUV threshold for defining high SUV were studied dependently. For each publication, we first obtained an estimate of the relative risk (RR) for comparing @entity0 with a low and those with a high SUV. Subsequently, we aggregated the individual RRs into a combined RR using the fixed-effects model to yield weighted mean pooled estimates with 95% confidence intervals (CIs). Publication bias was assessed with a funnel plot. A total of 6 clinical trials involving 453 @entity0 were included in the meta-analysis. The combined RR from the 6 reports for local control was 0.72 (95% CI: 0.63-0.81). The funnel plot revealed symmetrical distribution, indicating no evidence of significant publication bias. The increase in the SUV of the @entity1 was found to be a poor prognostic marker for @entity0 with @entity2 in the meta-analysis, which requires further confirmation in a meta-analysis based on individual @entity0 data.

title: XXXX standardized uptake value as a prognostic factor in primary @entity2 .

answer: @entity1


abstract: UNASSIGNED: Similar to @entity2 , there are clear associations between resistance or susceptibility to @entity1 and the classic human leukocyte antigen (HLA) profile of an individual. HLA-associated susceptibility to childhood @entity3 ( @entity3 ) may provide clues to leukemogenesis in general and to the role of other risk factors. The present study aimed to determine the association between the @entity4 genotype and susceptibility to @entity3 in @entity0 and to assess the prognostic value of @entity4 alleles in these @entity0 . This study included 50 @entity3 @entity0 who were consecutively admitted to the Pediatric Oncology Unit of Zagazig University Hospital and 50 gender-matched healthy volunteers as a control group. The @entity0 were subjected to full clinical history, thorough clinical examination and routine laboratory investigations. Molecular @entity4 typing for @entity0 and controls using the reverse sequence-specific oligonucleotide probe technique was performed. @entity4 *04 allele frequency was significantly higher in female @entity0 compared to that in female controls (P=0.03) and in @entity0 aged <10 years compared to those aged >= 10 years at the time of diagnosis (P=0.01). @entity4 *11 allele frequency was significantly higher in high-risk compared to standard-risk @entity0 (P=0.01) and in refractory @entity0 compared to those who achieved remission (P=0.02). In conclusion, the @entity4 *04 allele appears to be a female-specific susceptibility factor for the acquisition of @entity3 and it may affect the age of onset of @entity3 . In addition, the @entity4 *11 allele may be of prognostic significance in @entity3 . However, further larger studies are required to support the conclusions drawn from this study.

title: Human leukocyte antigen-DRB1 polymorphism in childhood XXXX .

answer: @entity3


abstract: INTRODUCTION: @entity0 exposed to potentially traumatic events (PTEs) are at high risk for developing @entity2 , including @entity6 ( @entity6 ), @entity3 ( @entity3 ), @entity4 ( @entity4 ), and @entity5 . However, this risk is not universal. Most @entity0 are resistant (i.e., remain asymptomatic), or recover following a brief symptomatic period. This study examined the psychological factors associated with resistant and recovered outcomes in a sample of high-risk @entity0 exposed to assault-related PTEs. METHOD: One hundred and fifty-nine @entity0 completed the Life Events Checklist and were administered the Structured Clinical Interview for DSM-IV @entity1 . This resulted in three groups: (1) no diagnosis (no past or current @entity2 diagnosis; n  =  56), (2) past diagnosis (a past @entity2 diagnosis, but none currently; n  =  31), and (3) current diagnosis (a current diagnosis of one or more @entity2 ; n  =  72). Groups were compared on sociodemographics, PTE exposure, psychopathology, health-related quality of life (HRQOL), and psychological resilience-related factors. RESULTS: The majority of respondents (79%) did not develop chronic @entity6 following assault exposure, and the most common @entity2 outcome was @entity4 (30%). High endorsement of mastery and social support were associated with the no diagnosis group; and greater reports of mastery and posttraumatic growth were associated with recovery from a past @entity2 . Furthermore, both resilient groups (i.e., no diagnosis and past diagnosis) scored higher on HRQOL measures compared with the current diagnosis group (P  <  0.001). CONCLUSION: Psychological resilience has ramifications to health and well-being, and identifying these factors has potential to inform preventive strategies and treatment interventions for assault exposed @entity0 .

title: Determinants of psychological resistance and recovery among XXXX exposed to assaultive trauma.

answer: @entity0


abstract: BACKGROUND: @entity4 ( @entity4 ) is one of the most common disk lesions, inducing @entity5 ( @entity5 ). Various therapeutic options have been proposed for treatment of @entity4 ( @entity4 ). Intradiscal injection of @entity6 has been suggested for treatment of @entity4 . OBJECTIVES: To determine the effect of intradiscal @entity6 injection on @entity2 score and disability in @entity0 with @entity5 from disk prolapsed. @entity0 AND METHODS: @entity0 with @entity5 diagnosed with @entity4 were enrolled in this clinical trial study. After prep and drape the area and under the fluoroscopy guide (c-arm), intradiscal injection of @entity6 / @entity1 mixture (4 mL, 40   g/mL) was performed. @entity2 score and functional ability of the @entity0 according to @entity3 Index (ODI) were measured prior to the injection (baseline) and then at 2 and 4 weeks and then at 3 and 6 months after the injection. RESULTS: Thirty @entity0 (17 females, 13 males) with the mean age of 58.6 y (range, 42-73 y) enrolled in the study. The mean    standard deviation (SD) of @entity2 score before intervention was 8.1    0.8. After two weeks, it was reduced to 3.2    0.6 (P < 0.001) and finally dropped to 2.0    0.6 sixth months after intervention (P = 0.0001). Functional status of ODI was 28.5    2.1 before intervention and showed significant reduction after two weeks (with the mean of 12.3), and it was almost sustained till sixth months after intervention, with the mean of 11.4 (P = 0.001). CONCLUSIONS: Altogether, @entity6 had significant positive effects on @entity0 with @entity4 unresponsive to other conservative and minimally invasive treatments.

title: Injection of intradiscal o2-o3 to reduce @entity2 and disability of @entity0 with XXXX due to prolapsed lumbar disk.

answer: @entity5


abstract: BACKGROUND: @entity4 ( @entity4 ) is one of the most common disk lesions, inducing @entity5 ( @entity5 ). Various therapeutic options have been proposed for treatment of @entity4 ( @entity4 ). Intradiscal injection of @entity6 has been suggested for treatment of @entity4 . OBJECTIVES: To determine the effect of intradiscal @entity6 injection on @entity2 score and disability in @entity0 with @entity5 from disk prolapsed. @entity0 AND METHODS: @entity0 with @entity5 diagnosed with @entity4 were enrolled in this clinical trial study. After prep and drape the area and under the fluoroscopy guide (c-arm), intradiscal injection of @entity6 / @entity1 mixture (4 mL, 40   g/mL) was performed. @entity2 score and functional ability of the @entity0 according to @entity3 Index (ODI) were measured prior to the injection (baseline) and then at 2 and 4 weeks and then at 3 and 6 months after the injection. RESULTS: Thirty @entity0 (17 females, 13 males) with the mean age of 58.6 y (range, 42-73 y) enrolled in the study. The mean    standard deviation (SD) of @entity2 score before intervention was 8.1    0.8. After two weeks, it was reduced to 3.2    0.6 (P < 0.001) and finally dropped to 2.0    0.6 sixth months after intervention (P = 0.0001). Functional status of ODI was 28.5    2.1 before intervention and showed significant reduction after two weeks (with the mean of 12.3), and it was almost sustained till sixth months after intervention, with the mean of 11.4 (P = 0.001). CONCLUSIONS: Altogether, @entity6 had significant positive effects on @entity0 with @entity4 unresponsive to other conservative and minimally invasive treatments.

title: Injection of intradiscal o2-o3 to reduce XXXX and disability of @entity0 with @entity5 due to prolapsed lumbar disk.

answer: @entity2


abstract: BACKGROUND: @entity4 ( @entity4 ) is one of the most common disk lesions, inducing @entity5 ( @entity5 ). Various therapeutic options have been proposed for treatment of @entity4 ( @entity4 ). Intradiscal injection of @entity6 has been suggested for treatment of @entity4 . OBJECTIVES: To determine the effect of intradiscal @entity6 injection on @entity2 score and disability in @entity0 with @entity5 from disk prolapsed. @entity0 AND METHODS: @entity0 with @entity5 diagnosed with @entity4 were enrolled in this clinical trial study. After prep and drape the area and under the fluoroscopy guide (c-arm), intradiscal injection of @entity6 / @entity1 mixture (4 mL, 40   g/mL) was performed. @entity2 score and functional ability of the @entity0 according to @entity3 Index (ODI) were measured prior to the injection (baseline) and then at 2 and 4 weeks and then at 3 and 6 months after the injection. RESULTS: Thirty @entity0 (17 females, 13 males) with the mean age of 58.6 y (range, 42-73 y) enrolled in the study. The mean    standard deviation (SD) of @entity2 score before intervention was 8.1    0.8. After two weeks, it was reduced to 3.2    0.6 (P < 0.001) and finally dropped to 2.0    0.6 sixth months after intervention (P = 0.0001). Functional status of ODI was 28.5    2.1 before intervention and showed significant reduction after two weeks (with the mean of 12.3), and it was almost sustained till sixth months after intervention, with the mean of 11.4 (P = 0.001). CONCLUSIONS: Altogether, @entity6 had significant positive effects on @entity0 with @entity4 unresponsive to other conservative and minimally invasive treatments.

title: Injection of intradiscal o2-o3 to reduce @entity2 and disability of XXXX with @entity5 due to prolapsed lumbar disk.

answer: @entity0


abstract: UNASSIGNED: The miR-200 family promotes the epithelial state by suppressing the @entity8 / @entity9 epithelial gene transcriptional repressors. To identify other miR-200-regulated genes, we isolated mRNAs bound to transfected biotinylated @entity14 in @entity1 @entity0 cells. In all, 520 mRNAs were significantly enriched in @entity14 binding at least twofold. Putative miR-200-regulated genes included @entity9 , enriched 3.5-fold in the pull down. However, @entity9 knockdown does not fully recapitulate @entity14 overexpression, suggesting that regulating other miR-200 targets contributes to miR-200's enhancement of epithelial gene expression. Candidate genes were highly enriched for @entity14 seed pairing in their 3'UTR and coding sequence and for genes that were downregulated by @entity14 overexpression. @entity6 and downstream MAPK signaling pathways were the most enriched pathways. Genes whose products mediate transforming growth factor (TGF)-b signaling were also significantly overrepresented, and miR-200 counteracted the suppressive effects of @entity2 and @entity4 ( @entity4 ) on epithelial gene expression. @entity14 regulated the 3'UTRs of 12 of 14 putative @entity14 -binding mRNAs tested. The extent of mRNA binding to @entity14 strongly correlated with gene suppression. Twelve targets of @entity14 ( @entity15 , @entity16 , @entity7 , @entity5 , @entity17 , @entity18 /14-3-3y, Ywhab/14-3-3b, @entity10 , @entity12 , @entity3 , @entity13 , @entity11 ) were experimentally validated by identifying their 3'UTR miR-200 recognition elements. @entity7 and @entity10 form a complex with @entity9 and Ywhab/14-3-3b and @entity18 /14-3-3y form a complex with @entity11 . These complexes that repress transcription assemble on epithelial gene promoters. miR-200 overexpression induced RNA polymerase II localization and reduced @entity9 and @entity11 binding to epithelial gene promoters. Expression of miR-200-resistant @entity10 modestly, but significantly, reduced epithelial gene induction by miR-200. miR-200 expression and @entity9 knockdown are known to inhibit cell invasion in in vitro assays. Knockdown of each of three novel miR-200 target genes identified here, @entity10 , @entity18 and @entity15 , also profoundly suppressed cell invasion. Thus, miR-200 suppresses @entity2 /BMP signaling, promotes epithelial gene expression and suppresses cell invasion by regulating a network of genes.Oncogene advance online publication, 23 March 2015; doi:10.1038/onc.2015.69.

title: miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the XXXX and @entity11 transcriptional repressor complexes.

answer: @entity9


abstract: UNASSIGNED: The miR-200 family promotes the epithelial state by suppressing the @entity8 / @entity9 epithelial gene transcriptional repressors. To identify other miR-200-regulated genes, we isolated mRNAs bound to transfected biotinylated @entity14 in @entity1 @entity0 cells. In all, 520 mRNAs were significantly enriched in @entity14 binding at least twofold. Putative miR-200-regulated genes included @entity9 , enriched 3.5-fold in the pull down. However, @entity9 knockdown does not fully recapitulate @entity14 overexpression, suggesting that regulating other miR-200 targets contributes to miR-200's enhancement of epithelial gene expression. Candidate genes were highly enriched for @entity14 seed pairing in their 3'UTR and coding sequence and for genes that were downregulated by @entity14 overexpression. @entity6 and downstream MAPK signaling pathways were the most enriched pathways. Genes whose products mediate transforming growth factor (TGF)-b signaling were also significantly overrepresented, and miR-200 counteracted the suppressive effects of @entity2 and @entity4 ( @entity4 ) on epithelial gene expression. @entity14 regulated the 3'UTRs of 12 of 14 putative @entity14 -binding mRNAs tested. The extent of mRNA binding to @entity14 strongly correlated with gene suppression. Twelve targets of @entity14 ( @entity15 , @entity16 , @entity7 , @entity5 , @entity17 , @entity18 /14-3-3y, Ywhab/14-3-3b, @entity10 , @entity12 , @entity3 , @entity13 , @entity11 ) were experimentally validated by identifying their 3'UTR miR-200 recognition elements. @entity7 and @entity10 form a complex with @entity9 and Ywhab/14-3-3b and @entity18 /14-3-3y form a complex with @entity11 . These complexes that repress transcription assemble on epithelial gene promoters. miR-200 overexpression induced RNA polymerase II localization and reduced @entity9 and @entity11 binding to epithelial gene promoters. Expression of miR-200-resistant @entity10 modestly, but significantly, reduced epithelial gene induction by miR-200. miR-200 expression and @entity9 knockdown are known to inhibit cell invasion in in vitro assays. Knockdown of each of three novel miR-200 target genes identified here, @entity10 , @entity18 and @entity15 , also profoundly suppressed cell invasion. Thus, miR-200 suppresses @entity2 /BMP signaling, promotes epithelial gene expression and suppresses cell invasion by regulating a network of genes.Oncogene advance online publication, 23 March 2015; doi:10.1038/onc.2015.69.

title: miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the @entity9 and XXXX transcriptional repressor complexes.

answer: @entity11


abstract: UNASSIGNED: Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting @entity1 . Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time. It is generally believed that differential TDRM-persistence is caused, at least partially, by variations in TDRM-fitness-costs. However, in vivo epidemiological evidence for the impact of fitness costs on TDRM-persistence is rare. Here, we studied the persistence of TDRM in @entity4 using longitudinally-sampled @entity2 sequences from the Swiss- @entity3 -Cohort-Study (SHCS). All treatment-na  ve individuals with TDRM at baseline were included. Persistence of TDRM was quantified via reversion rates (RR) determined with interval-censored survival models. Fitness costs of TDRM were estimated in the genetic background in which they occurred using a previously published and validated machine-learning algorithm (based on in vitro replicative capacities) and were included in the survival models as explanatory variables. In 857 sequential samples from 168 treatment-na  ve @entity0 , 17 TDRM were analyzed. RR varied substantially and ranged from 174.0/100- @entity0 -years;CI=[51.4, 588.8] (for 184V) to 2.7/100- @entity0 -years;[0.7, 10.9] (for 215D). RR increased significantly with fitness cost (increase by 1.6[1.3,2.0] per standard deviation of fitness costs). When subdividing fitness costs into the average fitness cost of a given mutation and the deviation from the average fitness cost of a mutation in a given genetic background, we found that both components were significantly associated with reversion-rates. Our results show that the substantial variations of TDRM persistence in the absence of drugs are associated with fitness-cost differences both among mutations and among different genetic backgrounds for the same mutation.

title: Persistence of Transmitted XXXX Drug Resistance Mutations Associated with Fitness Costs and Viral Genetic Backgrounds.

answer: @entity4


abstract: UNASSIGNED: Tumor progression depends on @entity0 milieu, which influences neovasculature formation and immunosuppression. Combining immunotherapy with antiangiogenic/antivascular therapy might be an effective therapeutic approach. The aim of our study was to elaborate an anticancer therapeutic strategy based on the induction of immune response which leads to polarization of @entity0 milieu. To achieve this, we developed a @entity0 cell-based vaccine. @entity4 peptide was used as a B16-F10 cell death-inducing agent. The lysates were used as a vaccine to immunize @entity1 bearing B16-F10 @entity2 . To further improve the therapeutic effect of the vaccine, we combined it with interleukin (IL)-12 gene therapy. IL-12, a cytokine with antiangiogenic properties, activates nonspecific and specific immune responses. We observed that combined therapy is significantly more effective (as compared with monotherapies) in inhibiting @entity0 growth. Furthermore, the tested combination polarizes the @entity0 microenvironment, which results in a switch from a proangiogenic/immunosuppressive to an antiangiogenic/immunostimulatory one. The switch manifests itself as a decreased number of @entity0 blood vessels, increased levels of @entity0 -infiltrating @entity3 (+), CD8(+) and NK cells, as well as lower level of suppressor lymphocytes (Treg). Our results suggest that polarizing @entity0 milieu by such combined therapy does inhibit @entity0 growth and seems to be a promising therapeutic strategy.

title: Combined Tumor Cell-Based Vaccination and Interleukin-12 Gene Therapy Polarizes the Tumor Microenvironment in XXXX .

answer: @entity1