abstract: The purpose of the study was to determine the feasibility of preserving ovarian function after heterotopic transplantation by means of microvascular @entity3 of the transplanted vascular pedicles to a set of preselected vessels. Six groups of 10 Sprague-Dawley inbred @entity0 were used in this study. Group I underwent bilateral ovariectomy operation and served as the ovariectomy control. Group II underwent bilateral ovariectomy followed by @entity1 . Group III underwent bilateral ovariectomy and isogenic heterotopic ovarian transplantation by means of microvascular @entity3 . Group IV served as the laparotomy sham-operated control. Group V served as the ovarian donor for group II. Group VI served as the donor of the @entity4 pedicle complex for group III. Postoperative ovarian @entity2 levels were measured, and histological characteristics were elucidated in groups I, II, III, and IV. The results demonstrated that the @entity2 level of the transplantation group was comparable to that of the sham operation group and was significantly higher than that of the implantation group. Histologically normal ovarian architecture was observed in the sham group (IV) and also in the transplantation group (III). Altered architecture was observed in the implantation group (II). These findings indicate that extraabdominal heterotopic ovarian transplantation with microvascular @entity3 led to normal ovarian hormonal function and was effective in preserving oocyte production capacity.

title: Evaluation of the hormonal function and histological features of heterotopic isogenic ovarian transplantation in XXXX .

answer: @entity0


abstract: OBJECTIVE: Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. @entity5 , which selectively inhibits the enzyme @entity3 , is a novel anti-inflammatory drug with minimal @entity1 effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of @entity5 on gastric permeability in comparison with placebo and @entity4 . DESIGN: We conducted a prospective, double-blind, cross-over study. SETTING: This study is carried out at Marmara University Hospital. @entity0 : Twenty-five healthy subjects entered the study but 19 subjects completed the treatment. INTERVENTION: Subjects were randomized to @entity5 100 mg twice daily, @entity4 600 mg twice daily or placebo for 7 days in pre-defined sequences. Treatments were separated by a 7 day washout period. MAIN OUTCOME MEASURE: Gastric permeability was assessed by measuring urinary excretion of @entity2 spectrophotometrically. RESULTS: @entity4 600 mg twice daily produced greater increases in gastric permeability compared with placebo or @entity5 (geometric mean of urinary @entity2 recovery was 59.15, 32.65 and 33.11 mg/h for @entity4 , placebo and @entity5 , respectively) (P < 0.001). @entity5 was generally better tolerated than @entity4 . CONCLUSIONS: When compared with @entity4 , @entity5 100 mg twice daily has no significant effect on gastric mucosa in healthy subjects.

title: Effects of selective COX-2 inhibitors on the gastric permeability of @entity2 : a controlled study with placebo and XXXX .

answer: @entity4


abstract: OBJECTIVE: Acute and chronic use of non-steroidal anti-inflammatory drugs can increase gastrointestinal permeability. @entity5 , which selectively inhibits the enzyme @entity3 , is a novel anti-inflammatory drug with minimal @entity1 effects while retaining anti-inflammatory efficacy. Our aim was to assess the potential effects of @entity5 on gastric permeability in comparison with placebo and @entity4 . DESIGN: We conducted a prospective, double-blind, cross-over study. SETTING: This study is carried out at Marmara University Hospital. @entity0 : Twenty-five healthy subjects entered the study but 19 subjects completed the treatment. INTERVENTION: Subjects were randomized to @entity5 100 mg twice daily, @entity4 600 mg twice daily or placebo for 7 days in pre-defined sequences. Treatments were separated by a 7 day washout period. MAIN OUTCOME MEASURE: Gastric permeability was assessed by measuring urinary excretion of @entity2 spectrophotometrically. RESULTS: @entity4 600 mg twice daily produced greater increases in gastric permeability compared with placebo or @entity5 (geometric mean of urinary @entity2 recovery was 59.15, 32.65 and 33.11 mg/h for @entity4 , placebo and @entity5 , respectively) (P < 0.001). @entity5 was generally better tolerated than @entity4 . CONCLUSIONS: When compared with @entity4 , @entity5 100 mg twice daily has no significant effect on gastric mucosa in healthy subjects.

title: Effects of selective COX-2 inhibitors on the gastric permeability of XXXX : a controlled study with placebo and @entity4 .

answer: @entity2


abstract: UNASSIGNED: The adipocyte derived hormone leptin plays a critical role in the control of reproduction via signalling in hypothalamic neurones. The drivers of the @entity3 , the @entity1 neurones, do not have the receptors for leptin. Therefore, intermediate leptin responsive neurones must provide leptin-to- @entity1 signalling. We investigated the populations of leptin responsive neurones that provide input to the rostral preoptic area (rPOA, where @entity1 cell bodies reside). Fluorescent retrograde tracer beads (RetroBeads) were injected into the rPOA of transgenic leptin receptor reporter ( @entity4 -eGFP) female @entity0 . Uptake of the RetroBeads by @entity4 -eGFP neurones was assessed throughout the hypothalamus. RetroBead uptake was most evident in the medial arcuate nucleus (Arc), the dorsomedial nucleus (DMN), and the ventral premammillary nucleus ( @entity5 ) of the hypothalamus. The uptake of RetroBeads specifically by @entity4 -eGFP neurones was highest in the medial Arc (18% of tracer-labelled neurons @entity4 -eGFP-positive). Since we have previously shown that neurones which are both leptin responsive and GABAergic play a critical role in leptin's regulation of fertility, we next focussed on the location of these populations. To address whether GABAergic neurones in leptin-responsive hypothalamic regions project to the rPOA, the experiment was repeated in @entity2 neurone reporter @entity0 (Vgat-tdTomato). Between 10 and 45% of RetroBead labelled neurones in the Arc were GABAergic, whereas uptake of tracer by GABAergic neurones in the DMN and @entity5 was very low (<5%). These results show that both leptin responsive and GABAergic neurones from the Arc project to the region of the @entity1 cell bodies. Our findings suggest that @entity4 -expressing @entity2 neurones from the Arc may be mediators of leptin-to- @entity1 signalling. This article is protected by copyright. All rights reserved.

title: Leptin Responsive and GABAergic Projections to the Rostral Preoptic Area in XXXX .

answer: @entity0


abstract: We used the movements of adult milking @entity1 among farms enrolled in the Dairy Herd Improvement (DHI) program in Ontario to explore the size of an epidemic that might result from farm-to-farm movements of @entity1 in the Province if a reportable long-incubation @entity2 ( @entity2 ) were introduced and not detected for 1-3 years after introduction. A directed network was created for each year (2004-2006) using all pairs of individual shipments, defined as the movement of one or more @entity1 on a single day, from a single source DHI farm to a single recipient DHI farm. A 3-year network was also developed that included all @entity1 shipments that took place during these 3 years. The lower and upper bounds of potential maximal epidemic size were estimated using four network-analysis measures: (1) the farm out-degree, (2) the size of the largest strong and weak components, (3) the bow-tie approach, classifying farms into six different areas of a directed network and (4) the @entity0 chain of a farm. All four of the DHI movement networks were found to be small-world, indicating that @entity0 could spread over considerable distances by shipments that linked potentially distant clusters of farms. The networks were also scale-free, indicating most farms had relatively few connections to other farms, while there were a few highly connected farms. Characterization of the yearly networks showed that 41-47% of DHI farms were not involved in any @entity1 shipments and were therefore not at risk of @entity0 from this movement network; furthermore, if @entity0 were introduced into a DHI farm that shipped animals that year, the @entity0 would have stopped at that farm (or at least, not been passed on by shipment of adult milking @entity1 ) >50% of the time, and 75% of the time only one more DHI farm would have become infected through animal movements. Compared to the @entity0 chain, which accounted for both the direction and the time sequence of shipments in the movement network, the other network-analysis measures provided biased estimates of potential epidemic size. The bow-tie approach provided a schematic representation of the level of risk of each farm in the network in spreading an @entity0 , but overestimated the lower- and upper-bound measures of potential epidemic size because it did not account for the time sequence of shipments. Our @entity0 -chain results suggest that introducing a long-incubation disease into the network of farms enrolled in the DHI program in Ontario that was not identified until 12 months after the incursion would, in a worst-case scenario, have resulted in 168 farms (representing 5% of all Ontario DHI herds) being infected as a consequence of adult @entity1 movements among DHI farms. This estimate increased to 850 farms (26% of all DHI herds) if the @entity0 were not identified for 36 months.

title: Estimating potential epidemic size following introduction of a long-incubation disease in scale-free connected networks of milking- XXXX movements in Ontario, Canada.

answer: @entity1


abstract: Obliteration of the fat plane surrounding the superior mesenteric artery has been described as characteristic of @entity8 . To determine the specificity of this and other computed tomography findings in the pancreas and peripancreatic region, scans of 86 @entity0 were reviewed without clinical history. Diagnoses included @entity5 (26 @entity0 ); @entity5 (14 @entity0 ); @entity4 (17 @entity0 ); metastatic @entity3 (14 @entity0 ); and normal findings (15 @entity0 ). Confluent @entity7 could not be reliably differentiated from a pancreatic mass except when @entity7 separated the common bile duct from the duodenum. Retrocrural @entity7 was unusual with @entity8 . The fat plane surrounding the superior mesenteric artery was obliterated with @entity8 (36%), @entity3 (29%), and @entity4 (24%), but not with @entity5 , although perivascular @entity1 was seen in 19%. Evaluation of the @entity6 was less rewarding. Obliteration of the superior mesenteric artery fat plane is a sign of @entity2 , but it is not specific for @entity8 . We propose that the superior mesenteric artery origin be considered within a paraaortic space, separate from the anterior pararenal space. This explains its characteristic lack of involvement by @entity5 .

title: The superior mesenteric artery fat plane: is obliteration pathognomonic of XXXX ?

answer: @entity8


abstract: PURPOSE: Although @entity2 ablation (EA) is effective in the treatment of cystic thyroid nodules, it is less effective in nodules with solid component. Therefore refractory cases with solid component require another treatment modality such as radiofrequency ablation (RFA), which is effective in both solid and cystic thyroid nodules. We prospectively evaluated the efficacy of additional RFA and factors related to @entity1 in @entity0 showing unsatisfactory results after a single session of EA. MATERIALS AND METHODS: Of 94 @entity0 with predominantly cystic thyroid nodules who underwent EA, 20 @entity0 underwent additional RFA because of incompletely resolved clinical problems (symptomatic score reduction <50%) and presence of residual solid component at 1-month follow-up on ultrasonography. Improvement of clinical symptoms and nodule @entity1 were evaluated 6 month later. We evaluated factors related to nodule @entity1 after EA and RFA. RESULTS: RFA after a single session of EA was effective in reducing mean symptom score from 4.8 to 1.1 (p<0.001), mean cosmetic score from 3.5 to 1.4 (p<0.001) and mean nodule volume from 11.3 to 0.9 mL (p<0.001). The only independent factor related to @entity1 after EA was the presence of a solid component (p<0.001), and EA was less effective in nodules when solid component >20% (p=0.001). We identified no factors related to @entity1 after RFA. CONCLUSION: RFA is effective in treatment of benign predominantly cystic thyroid nodules in @entity0 whose clinical problems were incompletely resolved after EA.

title: How to manage the @entity0 with unsatisfactory results after XXXX ablation for thyroid nodules: role of radiofrequency ablation.

answer: @entity2


abstract: PURPOSE: Although @entity2 ablation (EA) is effective in the treatment of cystic thyroid nodules, it is less effective in nodules with solid component. Therefore refractory cases with solid component require another treatment modality such as radiofrequency ablation (RFA), which is effective in both solid and cystic thyroid nodules. We prospectively evaluated the efficacy of additional RFA and factors related to @entity1 in @entity0 showing unsatisfactory results after a single session of EA. MATERIALS AND METHODS: Of 94 @entity0 with predominantly cystic thyroid nodules who underwent EA, 20 @entity0 underwent additional RFA because of incompletely resolved clinical problems (symptomatic score reduction <50%) and presence of residual solid component at 1-month follow-up on ultrasonography. Improvement of clinical symptoms and nodule @entity1 were evaluated 6 month later. We evaluated factors related to nodule @entity1 after EA and RFA. RESULTS: RFA after a single session of EA was effective in reducing mean symptom score from 4.8 to 1.1 (p<0.001), mean cosmetic score from 3.5 to 1.4 (p<0.001) and mean nodule volume from 11.3 to 0.9 mL (p<0.001). The only independent factor related to @entity1 after EA was the presence of a solid component (p<0.001), and EA was less effective in nodules when solid component >20% (p=0.001). We identified no factors related to @entity1 after RFA. CONCLUSION: RFA is effective in treatment of benign predominantly cystic thyroid nodules in @entity0 whose clinical problems were incompletely resolved after EA.

title: How to manage the XXXX with unsatisfactory results after @entity2 ablation for thyroid nodules: role of radiofrequency ablation.

answer: @entity0


abstract: INTRODUCTION: When laparoscopic radical prostatectomy (LRP) was introduced as a novel treatment option for @entity2 , it had to compete with the established open techniques. The short- and intermediate-term oncologic and functional outcomes were encouraging and comparable to those with retropubic radical prostatectomy. However, the long-term oncologic safety for LRP has yet to be fully elucidated. We evaluated the long-term oncologic outcomes of an initial series of @entity0 who had undergone LRP. @entity0 AND METHODS: An initial unselected and consecutive series of 100 @entity0 who had undergone LRP for clinically @entity2 from 1999 to 2001 was identified. The pre-, intra-, and postoperative data were collected. Biochemical recurrence (BCR) was defined as a @entity4 (PSA) value of  >=  0.2 ng/mL. The outcome measures were @entity1 control (CC), BCR-free survival (BCRFS), @entity1 -specific survival (CSS), and @entity3 ( @entity3 ). RESULTS: The mean @entity0 age was 64    7 years, and the mean preoperative PSA level was 9.6    8.3 ng/mL. Of the 100 @entity0 , 79 (79%) had stage pT2 and 15 (15%) had stage @entity5 disease. Positive surgical margins were found in 25 @entity0 (25%; 16.4% for pT2 and 40% for @entity5 ). The median follow-up time was 126 months (range, 60-176 months). The 5-year CC rate was 82%. The estimated 10-year BCRFS was 83% and 80% for @entity0 with stage pT2 and @entity5 @entity1 , respectively. The median time to BCR was 52 months (range, 6-144 months). The estimated 10-year CSS and @entity3 was 98% and 93%, respectively. CONCLUSION: Our long-term follow-up data from an initial unselected @entity0 cohort have indicated that LRP offers excellent long-term oncologic control for @entity0 with @entity2 .

title: Long-Term Oncologic Outcome of an Initial Series of Laparoscopic Radical Prostatectomy for Clinically Localized XXXX After a Median Follow-up of 10 Years.

answer: @entity2


abstract: OBJECTIVE: To evaluate the safety and early and late outcomes of carotid endarterectomy in treating extracranial @entity3 . METHODS: From January 2010 to September 2014, 572 consecutive @entity0 with @entity3 underwent 618 @entity4 operations. 470 @entity0 were males and 102 @entity0 were females. Their age range was 36-87 years old. Average age was 66 years old. Among these @entity0 , symptomatic @entity3 is 58.2%, @entity4 high-risk @entity0 is 26.9% and 35.6% @entity0 combined contralateral @entity6 heavy @entity5 or totally occlusion. RESULTS: All the operations were success. Overall, perioperative major adverse events ( @entity2 / @entity1 /MI, MAEs) rates were 3.7%. The risk of MAEs was not associated with whether symptomatic @entity3 , @entity4 high-risk @entity0 and the lesions of contralateral @entity6 or not. 511 @entity0 were followed up for a mean period of 42 months. MAEs rate in follow-up period is 8.5% and restenosis rate is 3.3%. The results of Kaplan-Meier survival analysis show symptomatic @entity3 and @entity4 high-risk @entity0 couldn't increase the risk of MAEs. However, heavy @entity5 in contralateral @entity6 could increase the rate of @entity2 and @entity1 in the late follow-ups. CONCLUSIONS: @entity4 is a safety and effective method to treat extracranial @entity3 . The keys to prevent perioperative complications include a comprehensive evaluation of the @entity0 ' condition, an optional and personal surgical plan prior to the operations, and a dedicated management during the operations.

title: [Experience of carotid endarterectomy in treating extracranial XXXX : early and mid-term outcomes of 618 cases].

answer: @entity3


abstract: OBJECTIVE: To test the antitumor effects of the @entity5 inhibitor @entity4 in @entity0 stem cells and total cells in vitro and in vivo. METHODS: In vitro studies, we sorted ESA(+) @entity6 (+) @entity9 (-/low) cells as stem cells using flow cytometry from primary @entity0 cells. Apoptosis and the cell cycle distributions of stem cells were examined by flow cytometry. The tumorigenicity of stem cells after treatment was investigated by soft agar colony formation assays. BALB/c @entity2 were injected with stem cells and the different treatments were administered. After necropsy, the expression of @entity8 , @entity7 , @entity3 , and phospho-AKT (Thr308) was analyzed by immunohistochemistry. RESULTS: Treatment with @entity4 resulted in growth inhibition of all stem cells in a dose-dependent manner. An increase in G0-G1 cell cycle arrest and an increased population of cells in early apoptosis were seen in @entity4 treatment. In vivo, the volumes of the xenograft @entity1 significantly decreased in @entity4 alone group compared to control group. CONCLUSIONS: @entity4 could inhibit the growth of both total @entity0 cells and sorted stem cells in vitro and in vivo.

title: [Drug sensitivity research of @entity5 inhibitor on XXXX stem cells].

answer: @entity0


abstract: OBJECTIVE: To test the antitumor effects of the @entity5 inhibitor @entity4 in @entity0 stem cells and total cells in vitro and in vivo. METHODS: In vitro studies, we sorted ESA(+) @entity6 (+) @entity9 (-/low) cells as stem cells using flow cytometry from primary @entity0 cells. Apoptosis and the cell cycle distributions of stem cells were examined by flow cytometry. The tumorigenicity of stem cells after treatment was investigated by soft agar colony formation assays. BALB/c @entity2 were injected with stem cells and the different treatments were administered. After necropsy, the expression of @entity8 , @entity7 , @entity3 , and phospho-AKT (Thr308) was analyzed by immunohistochemistry. RESULTS: Treatment with @entity4 resulted in growth inhibition of all stem cells in a dose-dependent manner. An increase in G0-G1 cell cycle arrest and an increased population of cells in early apoptosis were seen in @entity4 treatment. In vivo, the volumes of the xenograft @entity1 significantly decreased in @entity4 alone group compared to control group. CONCLUSIONS: @entity4 could inhibit the growth of both total @entity0 cells and sorted stem cells in vitro and in vivo.

title: [Drug sensitivity research of XXXX inhibitor on @entity0 stem cells].

answer: @entity5


abstract: @entity0 aortic @entity2 ( @entity2 ) phenotype can be altered by physical forces. This has been demonstrated by cyclic strain-induced changes in proliferation and alignment. However, the intracellular coupling pathways remain ill defined. In the present study, we examined whether the @entity4 and S6 kinase pathway were involved in the mitogenic and morphological changes seen in SMCs exposed to cyclic strain. We seeded @entity0 aortic SMCs on silastic membranes that were deformed with 150-mmHg vacuum. Cyclic strain induced both alignment and proliferation of SMCs. @entity3 , a specific inhibitor of @entity4 , hindered @entity2 alignment, but not proliferation. @entity1 , a specific inhibitor of the mTOR-S6 kinase pathway, attenuated strain-induced proliferation, but not alignment. Peak activation of @entity4 and S6 kinase was 351 +/- 76.9% at 5 min and 363 +/- 56.2% at 60 min compared with static control, respectively (P < 0.05). The results suggest that strain-induced @entity2 alignment is dependent on activation of @entity4 , but not S6 kinase. Strain induced @entity2 proliferation is S6 kinase, but not @entity4 activation, dependent.

title: Involvement of S6 kinase and XXXX mitogen activated protein kinase pathways in strain-induced alignment and proliferation of @entity0 aortic smooth muscle cells.

answer: @entity4


abstract: @entity0 aortic @entity2 ( @entity2 ) phenotype can be altered by physical forces. This has been demonstrated by cyclic strain-induced changes in proliferation and alignment. However, the intracellular coupling pathways remain ill defined. In the present study, we examined whether the @entity4 and S6 kinase pathway were involved in the mitogenic and morphological changes seen in SMCs exposed to cyclic strain. We seeded @entity0 aortic SMCs on silastic membranes that were deformed with 150-mmHg vacuum. Cyclic strain induced both alignment and proliferation of SMCs. @entity3 , a specific inhibitor of @entity4 , hindered @entity2 alignment, but not proliferation. @entity1 , a specific inhibitor of the mTOR-S6 kinase pathway, attenuated strain-induced proliferation, but not alignment. Peak activation of @entity4 and S6 kinase was 351 +/- 76.9% at 5 min and 363 +/- 56.2% at 60 min compared with static control, respectively (P < 0.05). The results suggest that strain-induced @entity2 alignment is dependent on activation of @entity4 , but not S6 kinase. Strain induced @entity2 proliferation is S6 kinase, but not @entity4 activation, dependent.

title: Involvement of S6 kinase and @entity4 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of XXXX aortic smooth muscle cells.

answer: @entity0


abstract: OBJECTIVE: To investigate the effects of @entity3 -rich saline on cardiomyocyte autophagy during @entity1 -reperfusion in aged @entity0 . METHODS: One hundred and fifty healthy male @entity0 , 18 months old, weighing 400-540 g were selected. The @entity0 were then randomly divided into 5 groups (n = 30): Normal control group (group I); Sham operation group (group II); @entity1 -reperfusion group (group III); @entity3 -rich saline group (group IV); Normal saline group (group V). No any processing in group I. In group II, the anterior descending branch was only exposed but not ligated. Myocardial I/R was induced by occlusion of anterior descending branch of left coronary artery for 30 min followed by 12 h and 24 h of reperfusion with Bimbaum. @entity3 -rich saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group IV. Normal saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group V. The @entity0 were sacrificed at 12 h and 24 h of reperfusion and hearts were removed. The pathological changes of myocardial tissue were detected by HE staining. The rate of cardiomyocyte autophagy were detected by the MDC fluorescent dye and flow cytometry instrument. The expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue was investigated by Western blot. RESULT: Compared with groups I and II, the rate of cardiomyocyte autophagy, the expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue were significantly increased at 12 h, 24 h in groups III, IV and V (F = 23.45, 26.65, 25.58; F = 23.16, 25.15, 27.85; F = 21.04, 24.83, 27.43; F = 22.15, 25.79, 29.05; F = 22.58, 27.25, 28.46), P < 0.05. Compared with group III and V, the rate of cardiomyocyte autophagy, the expression of @entity5 , @entity2 , Beclin1, @entity4 were significantly decreased at 12 h, 24 h in group IV (F = 21.29, 24.71; F = 22.37, 25.84; F = 20.48, 22.38; F = 21.76, 28.43; F = 22.54, 27.21), P < 0.05. CONCLUSION: @entity3 -rich saline can attenuate myocardial reperfusion injury through inhibiting cardiomyocyte autophagy. The mechanism may be associated with decreasing the expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue.

title: [Effect of @entity3 -rich saline on cardiomyocyte autophagy during XXXX -reperfusion in aged @entity0 ].

answer: @entity1


abstract: OBJECTIVE: To investigate the effects of @entity3 -rich saline on cardiomyocyte autophagy during @entity1 -reperfusion in aged @entity0 . METHODS: One hundred and fifty healthy male @entity0 , 18 months old, weighing 400-540 g were selected. The @entity0 were then randomly divided into 5 groups (n = 30): Normal control group (group I); Sham operation group (group II); @entity1 -reperfusion group (group III); @entity3 -rich saline group (group IV); Normal saline group (group V). No any processing in group I. In group II, the anterior descending branch was only exposed but not ligated. Myocardial I/R was induced by occlusion of anterior descending branch of left coronary artery for 30 min followed by 12 h and 24 h of reperfusion with Bimbaum. @entity3 -rich saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group IV. Normal saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group V. The @entity0 were sacrificed at 12 h and 24 h of reperfusion and hearts were removed. The pathological changes of myocardial tissue were detected by HE staining. The rate of cardiomyocyte autophagy were detected by the MDC fluorescent dye and flow cytometry instrument. The expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue was investigated by Western blot. RESULT: Compared with groups I and II, the rate of cardiomyocyte autophagy, the expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue were significantly increased at 12 h, 24 h in groups III, IV and V (F = 23.45, 26.65, 25.58; F = 23.16, 25.15, 27.85; F = 21.04, 24.83, 27.43; F = 22.15, 25.79, 29.05; F = 22.58, 27.25, 28.46), P < 0.05. Compared with group III and V, the rate of cardiomyocyte autophagy, the expression of @entity5 , @entity2 , Beclin1, @entity4 were significantly decreased at 12 h, 24 h in group IV (F = 21.29, 24.71; F = 22.37, 25.84; F = 20.48, 22.38; F = 21.76, 28.43; F = 22.54, 27.21), P < 0.05. CONCLUSION: @entity3 -rich saline can attenuate myocardial reperfusion injury through inhibiting cardiomyocyte autophagy. The mechanism may be associated with decreasing the expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue.

title: [Effect of XXXX -rich saline on cardiomyocyte autophagy during @entity1 -reperfusion in aged @entity0 ].

answer: @entity3


abstract: OBJECTIVE: To investigate the effects of @entity3 -rich saline on cardiomyocyte autophagy during @entity1 -reperfusion in aged @entity0 . METHODS: One hundred and fifty healthy male @entity0 , 18 months old, weighing 400-540 g were selected. The @entity0 were then randomly divided into 5 groups (n = 30): Normal control group (group I); Sham operation group (group II); @entity1 -reperfusion group (group III); @entity3 -rich saline group (group IV); Normal saline group (group V). No any processing in group I. In group II, the anterior descending branch was only exposed but not ligated. Myocardial I/R was induced by occlusion of anterior descending branch of left coronary artery for 30 min followed by 12 h and 24 h of reperfusion with Bimbaum. @entity3 -rich saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group IV. Normal saline 1 ml/100 g were injected intraperitoneally 5 min before reperfusion in group V. The @entity0 were sacrificed at 12 h and 24 h of reperfusion and hearts were removed. The pathological changes of myocardial tissue were detected by HE staining. The rate of cardiomyocyte autophagy were detected by the MDC fluorescent dye and flow cytometry instrument. The expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue was investigated by Western blot. RESULT: Compared with groups I and II, the rate of cardiomyocyte autophagy, the expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue were significantly increased at 12 h, 24 h in groups III, IV and V (F = 23.45, 26.65, 25.58; F = 23.16, 25.15, 27.85; F = 21.04, 24.83, 27.43; F = 22.15, 25.79, 29.05; F = 22.58, 27.25, 28.46), P < 0.05. Compared with group III and V, the rate of cardiomyocyte autophagy, the expression of @entity5 , @entity2 , Beclin1, @entity4 were significantly decreased at 12 h, 24 h in group IV (F = 21.29, 24.71; F = 22.37, 25.84; F = 20.48, 22.38; F = 21.76, 28.43; F = 22.54, 27.21), P < 0.05. CONCLUSION: @entity3 -rich saline can attenuate myocardial reperfusion injury through inhibiting cardiomyocyte autophagy. The mechanism may be associated with decreasing the expression of @entity5 , @entity2 , Beclin1, @entity4 in myocardial tissue.

title: [Effect of @entity3 -rich saline on cardiomyocyte autophagy during @entity1 -reperfusion in aged XXXX ].

answer: @entity0


abstract: OBJECTIVES: To examine the association between neuropsychiatric symptoms and risk of institutionalization and @entity5 . DESIGN: Analysis of longitudinal data. SETTING: The Aging, Demographics, and Memory Study (ADAMS). @entity0 : Five hundred thirty-seven adults aged 71 and older with @entity1 drawn from the @entity6 ( @entity6 ). MEASUREMENTS: @entity2 (delusions, @entity8 , @entity9 , @entity7 , apathy, elation, @entity4 , @entity10 , @entity2 , and aberrant motor behaviors) and @entity3 were identified using the Neuropsychiatric Inventory. A consensus panel in the ADAMS assigned cognitive category. Date of nursing home placement and information on @entity5 , functional limitations, medical comorbidity, and sociodemographic characteristics were obtained from the @entity6 and ADAMS. RESULTS: Overall, the presence of one or more neuropsychiatric symptoms was not associated with a significantly higher risk for institutionalization or @entity5 during the 5-year study period, although when assessing each symptom individually, @entity7 , delusions, and @entity9 were each associated with a significantly higher risk of institutionalization (hazard rate (HR)=3.06, 95% confidence interval (CI)=1.09-8.59 for @entity7 ; HR=5.74, 95% CI=1.94-16.96 for clinically significant delusions; HR=4.70, 95% CI=1.07-20.70 for clinically significant @entity9 ). Caregiver distress mediated the association between delusions and @entity9 and institutionalization. @entity7 and @entity8 were associated with significantly higher mortality (HR=1.56, 95% CI=1.08-2.26 for @entity7 ; HR=2.59, 95% CI=1.09-6.16 for clinically significant @entity8 ). CONCLUSION: Some, but not all, neuropsychiatric symptoms are associated with a higher risk of institutionalization and @entity5 in @entity0 with @entity1 also influences institutionalization. Interventions that better target and treat @entity7 , delusions, @entity9 , and @entity8 , as well as @entity3 , may help delay or prevent these negative clinical outcomes.

title: @entity2 and the risk of institutionalization and XXXX : the aging, demographics, and memory study.

answer: @entity5


abstract: OBJECTIVES: To examine the association between neuropsychiatric symptoms and risk of institutionalization and @entity5 . DESIGN: Analysis of longitudinal data. SETTING: The Aging, Demographics, and Memory Study (ADAMS). @entity0 : Five hundred thirty-seven adults aged 71 and older with @entity1 drawn from the @entity6 ( @entity6 ). MEASUREMENTS: @entity2 (delusions, @entity8 , @entity9 , @entity7 , apathy, elation, @entity4 , @entity10 , @entity2 , and aberrant motor behaviors) and @entity3 were identified using the Neuropsychiatric Inventory. A consensus panel in the ADAMS assigned cognitive category. Date of nursing home placement and information on @entity5 , functional limitations, medical comorbidity, and sociodemographic characteristics were obtained from the @entity6 and ADAMS. RESULTS: Overall, the presence of one or more neuropsychiatric symptoms was not associated with a significantly higher risk for institutionalization or @entity5 during the 5-year study period, although when assessing each symptom individually, @entity7 , delusions, and @entity9 were each associated with a significantly higher risk of institutionalization (hazard rate (HR)=3.06, 95% confidence interval (CI)=1.09-8.59 for @entity7 ; HR=5.74, 95% CI=1.94-16.96 for clinically significant delusions; HR=4.70, 95% CI=1.07-20.70 for clinically significant @entity9 ). Caregiver distress mediated the association between delusions and @entity9 and institutionalization. @entity7 and @entity8 were associated with significantly higher mortality (HR=1.56, 95% CI=1.08-2.26 for @entity7 ; HR=2.59, 95% CI=1.09-6.16 for clinically significant @entity8 ). CONCLUSION: Some, but not all, neuropsychiatric symptoms are associated with a higher risk of institutionalization and @entity5 in @entity0 with @entity1 also influences institutionalization. Interventions that better target and treat @entity7 , delusions, @entity9 , and @entity8 , as well as @entity3 , may help delay or prevent these negative clinical outcomes.

title: XXXX and the risk of institutionalization and @entity5 : the aging, demographics, and memory study.

answer: @entity2


abstract: OBJECTIVES: To determine whether the presence of high depressive symptoms (Center for Epidemiologic Studies Depression Scale (CES-D) score >=  14) diminished physical performance benefits after a comprehensive physical activity intervention in older adults. DESIGN: A post hoc analysis of data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study, a single-blind randomized controlled trial comparing a moderate-intensity physical activity intervention (PA) with a successful aging control (SA). SETTING: Multicenter U.S. institutions participating in the LIFE-P trial. @entity0 : Four hundred twenty-four sedentary, noninstitutionalized adults aged 70 to 89. MEASUREMENTS: @entity1 were assessed using the CES-D. Physical performance tests included the Short Physical Performance Battery (SPPB) and 400-m walk time (400 mw) at baseline and 6 and 12 months. RESULTS: Of the @entity0 , 15.8% had high depressive symptom scores (CES-D >=  14). For @entity0 with @entity1 , SPPB scores improved more in the PA than the SA group over 12 months (adjusted score difference +0.70; P < .001 at 6 months and +0.58; P = .004 at 12 months), and 400 mw times improved in the PA group at 6 months (adjusted score difference -0.41 minutes; P = .02). For @entity0 with high depressive symptoms, the difference in improvement fell short of statistical significance on the SPPB between the PA and SA groups (adjusted score difference +0.76 (P = .18) at 6 months and +0.94 (P = .12) at 12 months). CONCLUSION: The presence of high depressive symptoms did not substantially diminish physical performance benefits realized after a PA intervention in sedentary older adults.

title: XXXX and physical performance in the lifestyle interventions and independence for elders pilot study.

answer: @entity1


abstract: @entity9 ( @entity9 ), variant of acute inflammatory demyelinating @entity11 , is recognized as clinical triad ( @entity9 ). @entity7 antibodies play an important role in the pathogenesis of acute @entity11 including @entity9 . To our knowledge, there has been no report of @entity9 presenting with atypical alternating @entity5 or with concurrent elevation of serum GD1 and asialo-GM1 antibody titers, and negative titers of GQ1b antibody such as our @entity0 . Our objective is to report @entity9 with unusual symptoms and to share our diagnostic approach. We report a rare case of @entity9 presenting with alternating @entity5 , @entity2 , and @entity6 after a @entity4 . Initial neurological examination revealed @entity5 , @entity1 , positive Romberg sign, and @entity6 . The ice pack test was negative. Three days later, contralateral @entity5 was observed, associated with @entity9 and @entity6 . However, there was significant improvement of the previous @entity5 . Serology revealed elevated asialo-GM1 and GD1b antibodies. @entity3 receptor antibodies were negative. Cerebral spinal fluid revealed elevated IgG index. Nerve conduction studies (NCS) performed four days after the onset of symptoms showed normal nerve conduction velocities and F-waves, and absent bilateral @entity10 -reflexes. Repetitive nerve stimulation (3 Hz) showed no decrement of compound muscle action potentials. Trial with a single dose of @entity8 showed no clinical improvement. The symptoms resolved without intervention. NCS 18 days after onset of symptoms showed mildly prolonged F-waves and absent H-reflexes. This case highlights an atypical presentation of @entity9 and raises the awareness of a rare autoantibody associated with it.

title: Alternating XXXX associated with asialo-GM1 and GD1b antibodies.

answer: @entity5


abstract: BACKGROUND: Alemtuzumab has single-agent activity in relapsed @entity10 ( @entity10 ), but the optimal dose and/or schedule in combination with chemotherapy for first-line use is unknown. The primary objectives were to establish the maximally tolerated dose and pharmacokinetics (PK) of alemtuzumab combined in this way. @entity0 AND METHODS: Adult @entity0 with untreated CD52-positive (CD52(+)) @entity10 were enrolled in a phase I trial. Alemtuzumab was given subcutaneously in escalating doses and/or schedules in combination with @entity11 ( @entity6 , @entity5 , @entity8 and @entity2 ) using a 3+3 design. Trough PK of alemtuzumab were measured on day 1 of each 21-day cycle and B and T cell subsets were serially measured. RESULTS: Twenty @entity0 were enrolled across 4 dose levels. Dose-limiting @entity1 necessitated expansion at 10 mg weekly (fatal @entity4 ) and 60 mg every 3 weeks (grade 4 @entity7 ) dose levels. Maximally tolerated dose was not reached. Ten @entity0 developed asymptomatic cytomegalovirus reactivations at a median of 39 days (range, 4-99 days). Two @entity0 developed @entity3 . The overall and complete response rates were 68% and 37%, respectively. Highest day 1 alemtuzumab trough levels were achieved at 60 mg (1973 ng/mL), but with significant inter- and intradose variability. @entity9 at baseline was common and  T cell recovery was significantly delayed. CONCLUSION: With monitoring and prophylaxis, alemtuzumab 60 mg combined with @entity11 showed activity in CD52(+) @entity10 and achieved the highest drug levels.

title: Alemtuzumab and XXXX Chemotherapy for the Treatment of @entity10 : A Multi-Center Phase I Study.

answer: @entity11


abstract: BACKGROUND: Alemtuzumab has single-agent activity in relapsed @entity10 ( @entity10 ), but the optimal dose and/or schedule in combination with chemotherapy for first-line use is unknown. The primary objectives were to establish the maximally tolerated dose and pharmacokinetics (PK) of alemtuzumab combined in this way. @entity0 AND METHODS: Adult @entity0 with untreated CD52-positive (CD52(+)) @entity10 were enrolled in a phase I trial. Alemtuzumab was given subcutaneously in escalating doses and/or schedules in combination with @entity11 ( @entity6 , @entity5 , @entity8 and @entity2 ) using a 3+3 design. Trough PK of alemtuzumab were measured on day 1 of each 21-day cycle and B and T cell subsets were serially measured. RESULTS: Twenty @entity0 were enrolled across 4 dose levels. Dose-limiting @entity1 necessitated expansion at 10 mg weekly (fatal @entity4 ) and 60 mg every 3 weeks (grade 4 @entity7 ) dose levels. Maximally tolerated dose was not reached. Ten @entity0 developed asymptomatic cytomegalovirus reactivations at a median of 39 days (range, 4-99 days). Two @entity0 developed @entity3 . The overall and complete response rates were 68% and 37%, respectively. Highest day 1 alemtuzumab trough levels were achieved at 60 mg (1973 ng/mL), but with significant inter- and intradose variability. @entity9 at baseline was common and  T cell recovery was significantly delayed. CONCLUSION: With monitoring and prophylaxis, alemtuzumab 60 mg combined with @entity11 showed activity in CD52(+) @entity10 and achieved the highest drug levels.

title: Alemtuzumab and @entity11 Chemotherapy for the Treatment of XXXX : A Multi-Center Phase I Study.

answer: @entity10


abstract: UNASSIGNED: A simple, rapid and high-throughput liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of ten antiepileptic drugs in @entity0 plasma has been developed and validated. The method required only 10  L of plasma. After simple protein precipitation using @entity4 , the analytes and internal standard @entity10 were separated on a Zorbax SB-C18 column (50 * 4.6 mm, 2.7  m) using @entity4 /water as the mobile phase at a flow rate of 0.9 mL/min. The total run time was 6 min for each sample. The validation results of specificity, matrix effects, recovery, linearity, precision and accuracy were satisfactory. The lower limit of quantification was 0.04  g/mL for @entity6 , 0.02  g/mL for @entity8 , 0.01  g/mL for @entity7 , 0.4  g/mL for @entity13 , 0.1  g/mL for @entity12 , 0.15  g/mL for @entity11 , 0.06  g/mL for @entity9 , 0.3  g/mL for @entity3 , 0.03  g/mL for @entity5 , and 0.15  g/mL for @entity1 . The intraday precision and interday precision were less than 7.6%, with the accuracy ranging between -8.1 and 7.9%. The method was successfully applied to therapeutic drug monitoring of 1237 @entity0 with @entity2 after administration of standard antiepileptic drugs. The method has been proved to meet the high-throughput requirements in therapeutic drug monitoring. This article is protected by copyright. All rights reserved.

title: Simultaneous determination of ten antiepileptic drugs in XXXX plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring.

answer: @entity0


abstract: OBJECTIVE: The objective of the study was to develop and begin to evaluate a new measure of the centrality of @entity2 in @entity0 ' lives. DESIGN: The study was designed as a cross-sectional survey and cognitive interviews. SETTING: The study was set in an academic general internal medicine clinic. @entity0 : Sixty-five adult internal medicine @entity0 with chronic @entity2 (CNMP) participated in the study. OUTCOME MEASURES: We assessed content validity and clarity of the 10-item Centrality of @entity2 Scale (COPS) by soliciting feedback from @entity5 experts and by conducting cognitive interviews with @entity0 with CNMP. We assessed internal consistency reliability using Cronbach's alpha. We assessed construct validity by comparing the COPS with other measures of @entity5 morbidity including @entity2 severity, @entity3 , @entity1 , physical and mental health function, @entity4 , quality of life, and provider assessment. RESULTS: Health care providers felt the COPS had excellent face validity. Cognitive interviews revealed that @entity0 ' understanding of the items matched the intended construct, the scale measured an important concept, and items were easy to understand. The COPS had excellent internal consistency (alpha = 0.9). It was negatively associated with age (r = -0.29; P = 0.02), but not with other demographic characteristics. Higher COPS scores were associated with poorer physical (r = -0.48; P < 0.001) and mental (r = -0.39; P = 0.002) health function, quality of life (r = -0.36; P = 0.004), and provider assessment of stability (r = -0.38; P = 0.004) as well as with greater @entity2 grade (r = 0.55; P < 0.001), and @entity3 (r = 0.63; P < 0.001). In multivariate analyses, age, physical and mental health function, and @entity3 were independently associated with COPS. CONCLUSIONS: The COPS has excellent internal consistency and construct validity. Additional studies are needed to further validate the scale.

title: Development and preliminary psychometric testing of the centrality of XXXX scale.

answer: @entity2


abstract: UNASSIGNED: Autoimmune bullous diseases, such as pemphigus, @entity3 , and @entity4 , are uniquely associated with vulnerability in the mucocutaneous barrier against @entity2 . The management of immunobullous diseases is complex and may at times require immunosuppressive medications. Iatrogenic immunosuppression may increase susceptibility to vaccine-preventable illnesses. Currently, there are no guidelines to assist the clinician treating @entity0 with @entity1 regarding the delivery of various vaccinations. The aim of this review is to provide recommendations for immunization in the unique setting of @entity1 . Recommendations are based on careful review of the literature in other conditions requiring iatrogenic immunosuppression, as well as the most recent Centers for Disease Control and Prevention guidelines. Immunization with nonlive vaccines appears to be a safe and effective strategy for preventing @entity2 in the particularly susceptible @entity0 with @entity1 . Opportunities for live vaccine administration may become available at lower levels of immune suppression or during clinical remission when immunosuppressive regimens can be reduced. Anticipatory vaccination before the initiation of iatrogenic immunosuppression is ideal. Although immunologic response to vaccination may be suboptimal during immunosuppression, nonlive vaccination is strongly recommended for this @entity0 population.

title: Literature-based immunization recommendations for XXXX requiring immunosuppressive medications for autoimmune bullous dermatoses.

answer: @entity0


abstract: INTRODUCTION: Racial-ethnic minority status is a consistent risk factor for @entity1 , with associations extending to @entity2 and subthreshold @entity3 experiences. However, few epidemiologic studies have been conducted in the U.S., and evidence is inconsistent. Furthermore, no U.S. studies of youths have directly investigated the phenomenological overlap between @entity1 and @entity2 . We aimed to do so at the subthreshold level in the Philadelphia Neurodevelopmental Cohort. METHODS: @entity0 included 6533 individuals, age 11-21years, from a community healthcare network. Latent class analysis was used to form subtypes of sub- @entity3 based on 12 attenuated positive items and 7 @entity2 items without duration criteria. Associations between race-ethnicity ( @entity4 , Hispanic, "other") and sub- @entity3 subtype were estimated using latent class regression. RESULTS: Four classes were identified: Sub-positive Only (13.4%), @entity2 Only (15.5%), Both (9.1%), and Neither (62.0%). Minority @entity0 were generally more likely than non-Hispanic whites to belong to one of the three sub- @entity3 classes compared to the Neither class. Associations for Hispanics and @entity5 remained after adjustment for age, sex, and maternal education, and restriction to @entity0 without significant physical health conditions. Racial-ethnic disparities were greater in magnitude for the two classes characterized by sub-positive symptoms, Sub-positive Only and Both, than for the @entity2 Only class. This pattern was statistically significant among @entity5 . CONCLUSIONS: We found evidence for racial-ethnic disparities in empirically-derived subtypes of subthreshold @entity3 , broadly defined, among U.S. youths. Further research is needed to determine whether these disparities persist to the clinical disorder level in adulthood.

title: Racial-ethnic disparities in empirically-derived subtypes of subclinical XXXX among a U.S. sample of youths.

answer: @entity3


abstract: AIMS: Since 1979 the diseased kidneys of 96 @entity0 on replacement therapy with @entity3 due to chronic @entity5 have been followed to investigate the development of acquired cysts and @entity1 . This is a report of the 20-year follow-up. MATERIALS AND METHODS: Ninety-six @entity0 were followed using periodic CT scan and were divided into hemodialysis, renal transplantation, bilateral nephrectomy and deceased groups during the follow-up. In the hemodialysis group, 36 @entity0 (19 males, 17 females) were followed for 20 years. RESULTS: Kidney volumes which were 57.8 (1.51) (geometric mean (geometric SD)) ml at start of the follow-up had become 185.3 (2.03) ml 20 years later in males, and in females, 57.3 (1.64) ml had become 99.7 (2.36) ml. The increased rate was 3.2 (2.06) fold in males and 1.7 (2.57) fold in females. This @entity2 was due to acquired cysts. Kidney volumes at the 20-year follow-up had increased more significantly than those at the 15-year follow-up in males; however, kidney volumes at the 20-year follow-up had not changed in females, if compared with data at the 15-year follow-up. Kidney volumes in males at 20-year follow-up were significantly larger than those in females (p = 0.0232). Males with more than 3.2-fold in kidney volume increase at the 20-year follow-up were under the age of 40 at entry into this study (p = 0.0055), although the correlation between the degree of kidney volume increase and age was not significant (p = 0.0910). Kidney volumes in the transplantation group remained small. There was no new @entity6 development after 15-year follow-up except for the local recurrence of a previous operated case. Although 7 of 44 @entity0 died during the past 20 years due to @entity1 , no @entity0 died of @entity6 because of early detection and treatment. One @entity0 died of @entity4 , which is a complication of acquired @entity2 . CONCLUSION: Male preponderance of acquired cysts was maintained at the 20-year follow-up. There was a tendency for the rate of increase in acquired @entity2 to be larger in young males. No one died of @entity6 , although the incidence of @entity6 was high.

title: Twenty-year follow-up of acquired XXXX .

answer: @entity2


abstract: BACKGROUND: To elucidate the evolution of a lung-sparing strategy with @entity3 ( @entity3 ) and induction therapy for @entity2 ( @entity2 ). METHODS: We retrospectively reviewed 205 @entity0 with @entity2 who underwent pneumonectomy (PN, n  =  54) or @entity3 (n  =  151) from 1994 to 2013. The study period was divided into four 5-year periods, and surgical trends were analyzed, focusing on the PN: @entity3 ratio. RESULTS: PN was associated with a significantly advanced pathological stage, a larger @entity1 size and less pulmonary function compared with @entity3 . The PN group had higher 30-day (3.7 vs. 0  %, p  =  0.018) and 90-day (13.0 vs. 1.3  %, p  =  0.0003) mortality than the @entity3 group. The overall 5-year survival rate was significantly higher with @entity3 (71.5  %) versus PN (42.8  %, p  =  0.011) for @entity0 with pN0-1. The ratio of PN among total surgeries decreased significantly over the four periods (1994-1998, 1999-2003, 2004-2008, and 2009-2013) from 5.63  % to 3.17, 1.40, and 1.38  %, respectively (p  <  0.0001); in contrast, the PN: @entity3 ratio increased significantly from 1.64 to 2.50, 3.71, and 5.44, respectively (p  =  0.041). During the last period, when we introduced induction therapy, 38 of 651 who received surgery underwent induction therapy. The PN: @entity3 ratios of those who did and did not undergo induction therapy were 15 (PN: 1, @entity3 : 15) and 4.25 (PN: 8, @entity3 : 34), respectively. CONCLUSIONS: A lung-sparing strategy with @entity3 for @entity2 can decrease the PN rate to less than 2  % with less mortality. Induction therapy may facilitate @entity3 and increase the PN: @entity3 ratio.

title: Evolution of a Lung-Sparing Strategy with Sleeve Lobectomy and Induction Therapy for XXXX : 20-Year Experience at a Single Institution.

answer: @entity2


abstract: BACKGROUND: Endovascular @entity3 repair (EVAR) is a prophylactic procedure, so the decision to operate should consider, as recent guidelines suggest, the life expectancy of the @entity0 . Several models for predicting life span have been already designed, but little is known about how intervened @entity0 evolve in Southern European Countries, where the incidence of @entity4 , the main cause of @entity2 among these subjects, is low. METHODS: We conducted a retrospective analysis of 176 consecutive @entity0 who underwent elective EVAR at the Vascular Surgery Department of the Hospital del Mar (Barcelona, Spain) during 2000-2014. Cox regressions were performed to identify preoperative factors associated with long-term survival after EVAR, and a risk model was developed. RESULTS: Three- and five-year survival rates were 73.9 and 53.9  %, respectively. During the follow-up, 72 deaths (40.9  %) were registered, @entity1 being the most frequent cause (41.7  %). Preoperative variables negatively associated with long-term survival were serum @entity6 >= 150    mol/L (HR 2.5; 95  % CI 1.4-4.2), chronic obstructive pulmonary disease (HR 1.9; 95  % CI 1.2-3.1), @entity5 (HR 2.0; 95  % CI 1.2-3.4), and prior @entity1 history (HR 1.9; 95  % CI 1.2-3.1). Distal pulses present in both lower limbs were marginally associated with survival (HR 0.65; 95  % CI 0.4-1.07). The survival predictive model showed a good discrimination capacity (C statistic  =  0.703; 95  % CI 0.641-0.765). CONCLUSIONS: Long-term survival of @entity0 submitted to EVAR in our setting was worse than expected and markedly related to @entity1 . Our study suggests that predictive models for long-term survival after EVAR may be influenced by regional characteristics of the intervened population. This effect should be taken in consideration in the decision-making process of these @entity0 .

title: Survival After Endovascular Abdominal XXXX Repair in a Population with a Low Incidence of @entity4 .

answer: @entity3


abstract: BACKGROUND: Endovascular @entity3 repair (EVAR) is a prophylactic procedure, so the decision to operate should consider, as recent guidelines suggest, the life expectancy of the @entity0 . Several models for predicting life span have been already designed, but little is known about how intervened @entity0 evolve in Southern European Countries, where the incidence of @entity4 , the main cause of @entity2 among these subjects, is low. METHODS: We conducted a retrospective analysis of 176 consecutive @entity0 who underwent elective EVAR at the Vascular Surgery Department of the Hospital del Mar (Barcelona, Spain) during 2000-2014. Cox regressions were performed to identify preoperative factors associated with long-term survival after EVAR, and a risk model was developed. RESULTS: Three- and five-year survival rates were 73.9 and 53.9  %, respectively. During the follow-up, 72 deaths (40.9  %) were registered, @entity1 being the most frequent cause (41.7  %). Preoperative variables negatively associated with long-term survival were serum @entity6 >= 150    mol/L (HR 2.5; 95  % CI 1.4-4.2), chronic obstructive pulmonary disease (HR 1.9; 95  % CI 1.2-3.1), @entity5 (HR 2.0; 95  % CI 1.2-3.4), and prior @entity1 history (HR 1.9; 95  % CI 1.2-3.1). Distal pulses present in both lower limbs were marginally associated with survival (HR 0.65; 95  % CI 0.4-1.07). The survival predictive model showed a good discrimination capacity (C statistic  =  0.703; 95  % CI 0.641-0.765). CONCLUSIONS: Long-term survival of @entity0 submitted to EVAR in our setting was worse than expected and markedly related to @entity1 . Our study suggests that predictive models for long-term survival after EVAR may be influenced by regional characteristics of the intervened population. This effect should be taken in consideration in the decision-making process of these @entity0 .

title: Survival After Endovascular Abdominal @entity3 Repair in a Population with a Low Incidence of XXXX .

answer: @entity4


abstract: OBJECTIVES: This study sought to examine the relationship between @entity0 and coronary microvascular function in asymptomatic individuals using positron emission tomography (PET) and assessment of coronary flow reserve (CFR). BACKGROUND: Coronary microvascular dysfunction is an early precursor of @entity1 ( @entity1 ) thought to result from endothelial cell activation and @entity0 , but data are limited. METHODS: We examined 268 asymptomatic male monozygotic and dizygotic twins. Plasma biomarkers of @entity0 and endothelial cell activation included @entity4 ( @entity4 ), @entity2 , white blood cell count (WBC), @entity6 , and @entity5 . Blood flow quantitation was obtained with [    N] ammonia PET at rest and after @entity3 stress. CFR was measured as the ratio of maximum flow to baseline flow at rest; abnormal CFR was defined as a ratio < 2.5. A summed stress score for visible perfusion defects was calculated. RESULTS: In within-pair analyses, all biomarkers, except @entity6 , were higher in twins with lower CFR than their brothers with higher CFR (p < 0.05). This was observed in the entire sample, as well as within pairs discordant for a CFR of <2.5. Associations persisted after adjusting for summed stress score and @entity1 risk factors. In contrast no biomarker, except @entity2 , was related to the summed stress score of visible defects. CONCLUSIONS: Even in asymptomatic subjects, a decrease in coronary microvascular function is accompanied by a systemic inflammatory response, independent of @entity1 risk factors. Our results, using a controlled twin design, highlight the importance of coronary microvascular function in the early phases of @entity1 .

title: XXXX is related to coronary flow reserve detected by positron emission tomography in asymptomatic male twins.

answer: @entity0


abstract: OBJECTIVES: @entity2 and @entity5 are @entity6 antidepressants. Currently, there are no adequate, well-controlled studies on the fetal safety of these drugs. Our primary objective was to determine whether the use of @entity2 or @entity5 during pregnancy is associated with an increased risk for major @entity1 . Secondary outcomes of interest included rates of spontaneous and therapeutic @entity4 , rates of @entity3 , and birth weight. METHODS: Pregnant @entity0 from 5 centres who had been exposed to these drugs (n = 147) were enrolled in the study during their first trimester. We compared the @entity0 with 2 groups of @entity0 who took either other antidepressant drugs (n = 147) or nonteratogenic drugs (n = 147). All the @entity0 were followed up after delivery to ascertain pregnancy outcome and the health of the baby. RESULTS: We have completed 147 follow-ups. There were 121 (82.4%) live births, 20 (13.6%) spontaneous @entity4 , and 6 (4%) therapeutic @entity4 . Of the live births, there were 2 (1.6%) major @entity1 . In all cases, drug exposure occurred during the first trimester, with 52 (35%) of the @entity0 using these drugs throughout pregnancy. The mean gestational age at birth was 38 weeks (SD 4.2), and the mean birth weight was 3306.34 g (SD 655). We found no statistically significant differences among the 3 groups in any of the endpoints of interest that we examined. Of the sample, 58 @entity0 were exposed to @entity2 , and 89 were exposed to @entity5 . CONCLUSION: Our results suggest that these drugs do not increase the rates of major @entity1 above the baseline rate of 1% to 3%.

title: A multicentre prospective controlled study to determine the safety of @entity2 and XXXX use during pregnancy.

answer: @entity5


abstract: OBJECTIVES: @entity2 and @entity5 are @entity6 antidepressants. Currently, there are no adequate, well-controlled studies on the fetal safety of these drugs. Our primary objective was to determine whether the use of @entity2 or @entity5 during pregnancy is associated with an increased risk for major @entity1 . Secondary outcomes of interest included rates of spontaneous and therapeutic @entity4 , rates of @entity3 , and birth weight. METHODS: Pregnant @entity0 from 5 centres who had been exposed to these drugs (n = 147) were enrolled in the study during their first trimester. We compared the @entity0 with 2 groups of @entity0 who took either other antidepressant drugs (n = 147) or nonteratogenic drugs (n = 147). All the @entity0 were followed up after delivery to ascertain pregnancy outcome and the health of the baby. RESULTS: We have completed 147 follow-ups. There were 121 (82.4%) live births, 20 (13.6%) spontaneous @entity4 , and 6 (4%) therapeutic @entity4 . Of the live births, there were 2 (1.6%) major @entity1 . In all cases, drug exposure occurred during the first trimester, with 52 (35%) of the @entity0 using these drugs throughout pregnancy. The mean gestational age at birth was 38 weeks (SD 4.2), and the mean birth weight was 3306.34 g (SD 655). We found no statistically significant differences among the 3 groups in any of the endpoints of interest that we examined. Of the sample, 58 @entity0 were exposed to @entity2 , and 89 were exposed to @entity5 . CONCLUSION: Our results suggest that these drugs do not increase the rates of major @entity1 above the baseline rate of 1% to 3%.

title: A multicentre prospective controlled study to determine the safety of XXXX and @entity5 use during pregnancy.

answer: @entity2


abstract: The knee joints of 36 @entity0 were immobilised in a padded plaster cast (18 in the flexed and 18 in the extended position) for 1, 2 and 3 weeks. The femoral articular cartilage was then examined under the scanning electron microscope. After 1 week's immobilisation in the flexed position, the surface layer of the cartilage showed disruption and the superficial chondrocytes were @entity1 . The sites of the @entity1 chondrocytes were seen as pits on the cartilage surface. In the animals whose knees were immobilised in the extended position, the changes were not so great in severity or extent. After 2 weeks, more advanced changes could be detected in both groups, but they were more severe in the flexed group. After 3 weeks the changes in articular cartilage were diffuse in the flexed, but focal in the extended group. Diffuse @entity1 of chondrocytes, with pit formation on the surface and disruption and disintegration of the collagen fibres, was seen to some extent in all the animals. In the flexed group the changes extended to the whole weightbearing surface of the articular cartilage of the femur, except the intercondylar sulcus. In the extended group, a superficial fibre network was found without the formation of closely packed collagen fibre bundles, and the changes in the chondrocytes were seen only in localised zones. The authors suggest that during immobilisation, especially in the flexed position, articular @entity2 occurs due to a decreased amount of synovial fluid, the increased compression of the cartilage surfaces and the increased intra-articular pressure. This @entity3 and @entity1 of the superficial chondrocytes and the superficial cartilage layer.

title: Fine structural changes in the articular cartilage of the XXXX 's knee following short-term immobilisation in various positions: a scanning electron microscopical study.

answer: @entity0


abstract: The effects of @entity4 , @entity8 and @entity2 on erythrocytes, hepatocytes, @entity5 ( @entity6 )-liposomes and surface tension were studied at various concentrations. @entity4 at 10 mM caused a slight inhibition of @entity3 in @entity0 erythrocytes. @entity8 at 4 and 10 mM and @entity2 at 0.6 to 10 mM caused a significant inhibition of @entity3 . In the enzyme leakage from isolated @entity0 hepatocytes, @entity4 at 0.001 to 0.4 mM and 2 to 10 mM, @entity8 at 2 to 10 mM and @entity2 at 0.001 to 4 mM caused an inhibition in GOT leakage. The leakage of @entity7 from hepatocytes was inhibited by @entity4 at 0.4 to 10 mM, @entity8 at 2 to 10 mM, and @entity2 at 0.001 to 4 mM. @entity2 at 10 mM caused increases in GOT and @entity7 leakage. The inhibition of @entity4 and @entity2 on the LDH leakage in hepatocytes were observed at a concentration of 0.001 mM and 0.1 to 1 mM, respectively. @entity8 or @entity2 at 10 mM caused an increase in LDH leakage. Phase-transition temperature of @entity6 -liposomes was @entity1 by @entity4 and @entity2 at 1 to 10 mM and by @entity8 at 5 and 10 mM. @entity8 at 1 and 10 mM and @entity2 at 10 mM caused a @entity1 of surface tension, but @entity4 caused no change in surface tension. The order of effects on erythrocyte, hepatocyte and @entity6 -liposome membranes was @entity2 greater than @entity4 greater than or equal to @entity8 . In the present study, @entity4 and its related compound showed a positive correlation between their effects on various membranes and germicidal effects as evaluated by the @entity4 coefficient, but the effects were not related to a @entity1 of surface tension.

title: [Effects of XXXX and related compounds on erythrocytes and hepatocytes from @entity0 and @entity5 -liposomes].

answer: @entity4


abstract: The effects of @entity4 , @entity8 and @entity2 on erythrocytes, hepatocytes, @entity5 ( @entity6 )-liposomes and surface tension were studied at various concentrations. @entity4 at 10 mM caused a slight inhibition of @entity3 in @entity0 erythrocytes. @entity8 at 4 and 10 mM and @entity2 at 0.6 to 10 mM caused a significant inhibition of @entity3 . In the enzyme leakage from isolated @entity0 hepatocytes, @entity4 at 0.001 to 0.4 mM and 2 to 10 mM, @entity8 at 2 to 10 mM and @entity2 at 0.001 to 4 mM caused an inhibition in GOT leakage. The leakage of @entity7 from hepatocytes was inhibited by @entity4 at 0.4 to 10 mM, @entity8 at 2 to 10 mM, and @entity2 at 0.001 to 4 mM. @entity2 at 10 mM caused increases in GOT and @entity7 leakage. The inhibition of @entity4 and @entity2 on the LDH leakage in hepatocytes were observed at a concentration of 0.001 mM and 0.1 to 1 mM, respectively. @entity8 or @entity2 at 10 mM caused an increase in LDH leakage. Phase-transition temperature of @entity6 -liposomes was @entity1 by @entity4 and @entity2 at 1 to 10 mM and by @entity8 at 5 and 10 mM. @entity8 at 1 and 10 mM and @entity2 at 10 mM caused a @entity1 of surface tension, but @entity4 caused no change in surface tension. The order of effects on erythrocyte, hepatocyte and @entity6 -liposome membranes was @entity2 greater than @entity4 greater than or equal to @entity8 . In the present study, @entity4 and its related compound showed a positive correlation between their effects on various membranes and germicidal effects as evaluated by the @entity4 coefficient, but the effects were not related to a @entity1 of surface tension.

title: [Effects of @entity4 and related compounds on erythrocytes and hepatocytes from @entity0 and XXXX -liposomes].

answer: @entity5


abstract: The effects of @entity4 , @entity8 and @entity2 on erythrocytes, hepatocytes, @entity5 ( @entity6 )-liposomes and surface tension were studied at various concentrations. @entity4 at 10 mM caused a slight inhibition of @entity3 in @entity0 erythrocytes. @entity8 at 4 and 10 mM and @entity2 at 0.6 to 10 mM caused a significant inhibition of @entity3 . In the enzyme leakage from isolated @entity0 hepatocytes, @entity4 at 0.001 to 0.4 mM and 2 to 10 mM, @entity8 at 2 to 10 mM and @entity2 at 0.001 to 4 mM caused an inhibition in GOT leakage. The leakage of @entity7 from hepatocytes was inhibited by @entity4 at 0.4 to 10 mM, @entity8 at 2 to 10 mM, and @entity2 at 0.001 to 4 mM. @entity2 at 10 mM caused increases in GOT and @entity7 leakage. The inhibition of @entity4 and @entity2 on the LDH leakage in hepatocytes were observed at a concentration of 0.001 mM and 0.1 to 1 mM, respectively. @entity8 or @entity2 at 10 mM caused an increase in LDH leakage. Phase-transition temperature of @entity6 -liposomes was @entity1 by @entity4 and @entity2 at 1 to 10 mM and by @entity8 at 5 and 10 mM. @entity8 at 1 and 10 mM and @entity2 at 10 mM caused a @entity1 of surface tension, but @entity4 caused no change in surface tension. The order of effects on erythrocyte, hepatocyte and @entity6 -liposome membranes was @entity2 greater than @entity4 greater than or equal to @entity8 . In the present study, @entity4 and its related compound showed a positive correlation between their effects on various membranes and germicidal effects as evaluated by the @entity4 coefficient, but the effects were not related to a @entity1 of surface tension.

title: [Effects of @entity4 and related compounds on erythrocytes and hepatocytes from XXXX and @entity5 -liposomes].

answer: @entity0


abstract: UNASSIGNED: Circulating @entity3 cells (CTCs) are cells that shed from a primary @entity3 and enter the peripheral blood circulation. The CTCs are closely associated with @entity3 development and @entity2 because of its high heterogeneity. However, there are still no effective methods to detect single-cell heterogeneity of the CTCs. To this end, we developed a method to detect gene mutation in CTCs at the single-cell level and applied it to the detection of @entity4 gene mutation in @entity1 CTC. Specifically, the rare CTCs were captured from blood using an integrated microfluidic system, and then were released into a microchip with thousands of nanoliter wells to isolate single CTC. The single CTC was then transferred into a PCR tube under the microscope for single-cell genome amplification and detection of @entity4 gene mutation. We firstly modified chip and capillary and optimized PCR conditions (annealing temperature, number of cycles) using @entity5 ( @entity5 ) cell lines A549, NCI-H1650 and NCI-H1975 as samples, which showed maximal amplification after 30 cycles with an annealing temperature at 59   . We then successfully detected blood samples from @entity5 @entity0 using this method. 5 CTCs were obtained from 2 mL @entity0 's blood and the sequencing of @entity4 exons 18, 19, 20 and 21 showed no mutations. Our results demonstrated that this method is sensitive enough to detect gene mutation in single CTC and has guiding significance in clinic research.

title: Single-cell detection of @entity4 gene mutation in circulating @entity3 cells in XXXX .

answer: @entity1


abstract: UNASSIGNED: Circulating @entity3 cells (CTCs) are cells that shed from a primary @entity3 and enter the peripheral blood circulation. The CTCs are closely associated with @entity3 development and @entity2 because of its high heterogeneity. However, there are still no effective methods to detect single-cell heterogeneity of the CTCs. To this end, we developed a method to detect gene mutation in CTCs at the single-cell level and applied it to the detection of @entity4 gene mutation in @entity1 CTC. Specifically, the rare CTCs were captured from blood using an integrated microfluidic system, and then were released into a microchip with thousands of nanoliter wells to isolate single CTC. The single CTC was then transferred into a PCR tube under the microscope for single-cell genome amplification and detection of @entity4 gene mutation. We firstly modified chip and capillary and optimized PCR conditions (annealing temperature, number of cycles) using @entity5 ( @entity5 ) cell lines A549, NCI-H1650 and NCI-H1975 as samples, which showed maximal amplification after 30 cycles with an annealing temperature at 59   . We then successfully detected blood samples from @entity5 @entity0 using this method. 5 CTCs were obtained from 2 mL @entity0 's blood and the sequencing of @entity4 exons 18, 19, 20 and 21 showed no mutations. Our results demonstrated that this method is sensitive enough to detect gene mutation in single CTC and has guiding significance in clinic research.

title: Single-cell detection of XXXX gene mutation in circulating @entity3 cells in @entity1 .

answer: @entity4


abstract: UNASSIGNED: Circulating @entity3 cells (CTCs) are cells that shed from a primary @entity3 and enter the peripheral blood circulation. The CTCs are closely associated with @entity3 development and @entity2 because of its high heterogeneity. However, there are still no effective methods to detect single-cell heterogeneity of the CTCs. To this end, we developed a method to detect gene mutation in CTCs at the single-cell level and applied it to the detection of @entity4 gene mutation in @entity1 CTC. Specifically, the rare CTCs were captured from blood using an integrated microfluidic system, and then were released into a microchip with thousands of nanoliter wells to isolate single CTC. The single CTC was then transferred into a PCR tube under the microscope for single-cell genome amplification and detection of @entity4 gene mutation. We firstly modified chip and capillary and optimized PCR conditions (annealing temperature, number of cycles) using @entity5 ( @entity5 ) cell lines A549, NCI-H1650 and NCI-H1975 as samples, which showed maximal amplification after 30 cycles with an annealing temperature at 59   . We then successfully detected blood samples from @entity5 @entity0 using this method. 5 CTCs were obtained from 2 mL @entity0 's blood and the sequencing of @entity4 exons 18, 19, 20 and 21 showed no mutations. Our results demonstrated that this method is sensitive enough to detect gene mutation in single CTC and has guiding significance in clinic research.

title: Single-cell detection of @entity4 gene mutation in circulating XXXX cells in @entity1 .

answer: @entity3


abstract: INTRODUCTION: Data from single-center series suggest that a delay in time to radical cystectomy (RC) more than 3 months after diagnosis of @entity1 ( @entity1 ) is associated with pathological upstaging and decreased survival. However, limited data is available from population-based studies. In this study, the effect of delayed RC was assessed in a nationwide cohort. MATERIALS AND METHODS: @entity0 who underwent RC between 2006 and 2010 with primary clinical T2-T4N0M0 @entity1 were selected using the Netherlands Cancer Registry database. Data from the Netherlands Cancer Registry was supplemented with data from the Nationwide Network and Registry of Histo- and Cytopathology database in case of incomplete information. The cohort was divided in @entity0 who underwent RC  <=3 months (group I) vs. @entity0 who underwent RC >3 months (group II). Median time from @entity1 diagnosis to RC, variables associated with delayed RC >3 and the effect of delayed RC on staging and @entity2 ( @entity2 ) were evaluated in @entity0 who underwent neoadjuvant therapy and @entity0 who did not. RESULTS: A total of 1,782 @entity0 were included. Median follow-up time was 5.1 years for living @entity0 and 1.3 years for deceased @entity0 . Median time from @entity1 diagnosis to RC was 50 days (interquartile range: 27 days) and 93% of @entity0 underwent RC <=3 months. @entity0 older than 75 years (odds ratio [OR] = 0.50; 95% CI: 0.32-0.77), referred for RC (OR = 0.41; 95% CI: 0.26-0.69), and treated in a university hospital (OR = 0.34; 95% CI: 0.21-0.56) were less likely to undergo RC <=3 months. Pathologic upstaging rate (43.9% vs. 42.1%) and node-positive disease rate (20.2% vs. 21.7%) did not differ for group I and II. Delayed RC>3 months was not associated with decreased @entity2 adjusting for confounding variables (hazard ratio = 1.16; 95% CI: 0.91-1.48; P = 0.25). Median time from @entity1 diagnosis to RC in @entity0 that received neoadjuvant therapy (n = 105) was 133 days (interquartile range: 62 days). Adjusting for confounding variables, delayed RC>3 months was not associated with @entity2 (hazard ratio = 0.90; 95% CI: 0.45-1.82). CONCLUSIONS: The vast majority of @entity0 underwent RC within 3 months after diagnosis of @entity1 , as recommended in the European Association of Urology @entity1 guideline. Delayed RC for more than 3 months had no adverse effect on staging and survival.

title: The effect of the time interval between diagnosis of XXXX and radical cystectomy on staging and survival: A Netherlands Cancer Registry analysis.

answer: @entity1


abstract: We describe a very rare case of nonfunctional @entity8 (NFPA) that exhibited corticotrophic activity after resection and radiotherapy. The possible mechanisms of the transformation from NFPA to @entity11 ( @entity11 ) are discussed.A 43-year-old @entity0 presented with @entity3 , and hyposexuality. He had no symptoms suggestive of @entity6 , and 8am plasma @entity7 concentration was 67.88ng/mL. Brain imaging revealed a 15*15*21-mm sellar mass suggestive of a macroadenoma. The @entity1 was resected by transsphenoidal surgery and identified by immunohistochemical analysis as a chromophobic @entity5 that did not stain for pituitary hormones. The @entity0 was treated with @entity4 and @entity9 replacement therapy. After a third recurrence, the @entity0 presented with clinical features and physical signs of @entity6 . Plasma @entity10 ( @entity10 ) and @entity7 concentrations were elevated, and there was a loss of circadian rhythms. Inferior petrosal sinus sampling after desmopressin showed the central-peripheral @entity10 ratio was greater than 3:1. A repeat transsphenoidal resection was undertaken. Immunohistochemistry revealed @entity10 positivity. Three months following surgery, imaging @entity2 , but plasma @entity10 remained elevated. He was referred for postoperative Gamma Knife radiotherapy.The immunological activity and biological features of the hormones secreted from a @entity8 vary with time. Because long-term outcomes are unpredictable, postoperative follow-up is essential to detect postoperative transformation from NFPA to @entity11 .

title: @entity11 After Treatment of Nonfunctional XXXX : A Case Report and Literature Review.

answer: @entity8


abstract: We describe a very rare case of nonfunctional @entity8 (NFPA) that exhibited corticotrophic activity after resection and radiotherapy. The possible mechanisms of the transformation from NFPA to @entity11 ( @entity11 ) are discussed.A 43-year-old @entity0 presented with @entity3 , and hyposexuality. He had no symptoms suggestive of @entity6 , and 8am plasma @entity7 concentration was 67.88ng/mL. Brain imaging revealed a 15*15*21-mm sellar mass suggestive of a macroadenoma. The @entity1 was resected by transsphenoidal surgery and identified by immunohistochemical analysis as a chromophobic @entity5 that did not stain for pituitary hormones. The @entity0 was treated with @entity4 and @entity9 replacement therapy. After a third recurrence, the @entity0 presented with clinical features and physical signs of @entity6 . Plasma @entity10 ( @entity10 ) and @entity7 concentrations were elevated, and there was a loss of circadian rhythms. Inferior petrosal sinus sampling after desmopressin showed the central-peripheral @entity10 ratio was greater than 3:1. A repeat transsphenoidal resection was undertaken. Immunohistochemistry revealed @entity10 positivity. Three months following surgery, imaging @entity2 , but plasma @entity10 remained elevated. He was referred for postoperative Gamma Knife radiotherapy.The immunological activity and biological features of the hormones secreted from a @entity8 vary with time. Because long-term outcomes are unpredictable, postoperative follow-up is essential to detect postoperative transformation from NFPA to @entity11 .

title: XXXX After Treatment of Nonfunctional @entity8 : A Case Report and Literature Review.

answer: @entity11


abstract: @entity1 ( @entity1 ) is a recognized cause of @entity2 . By using a cross-sectional comparative study, we aimed to verify whether neuropsychological performance of untreated @entity1 @entity0 conforms to a distinctive pattern. Forty-nine newly diagnosed, untreated @entity1 @entity0 , 27 with @entity4 ( @entity4 ), 31 with mild to moderate @entity4 of @entity3 (DAT) and 63 with severe @entity6 ( @entity6 ), all free from major comorbid dementing conditions were chosen for the study. The groups were matched for age and education. We found a bimodal distribution of cognitive performance in @entity1 group, which was therefore divided into two clusters having better (OSAb, n = 35) and worse (OSAw, n = 14) performance on a battery of 10 cognitive indexes. Cognitive performances of OSAb, OSAw, @entity4 , DAT and @entity6 were compared by discriminant analysis. OSAb performed better than OSAw in all but one test. Deductive thinking and verbal attainment were more severely impaired in OSAw than in @entity6 @entity0 . Constructive ability, deductive thinking and both verbal attainment and immediate memory were comparably impaired in OSAw and DAT. The mean neuropsychological scores of OSAw and @entity4 were comparable, but 71% of OSAw @entity0 had a distinctive cognitive profile, i.e. a group specific pattern of @entity2 , according to discriminant analysis. One of four newly diagnosed @entity1 @entity0 had a severe and distinctive @entity5 mainly involving inductive and deductive thinking, and constructive ability. Some analogy with cognitive pattern of @entity4 suggests that a mainly subcortical damage underlies this dysfunction.

title: Does XXXX conform to a distinctive pattern in obstructive sleep apnea syndrome?

answer: @entity2


abstract: We reported on 1 case of epithelioid inflammatory @entity3 (EIMS) that occurred in the colon and resulted in an incomplete @entity8 .A 65-year-old male @entity0 presented with @entity6 without any obvious predisposing cause. He reported a paroxysmal dull @entity2 . @entity4 occurred occasionally. The symptoms appeared repeatedly and became progressively more aggravated. The @entity0 sought medical advice in our hospital, and his enteroscopy showed @entity7 and an incomplete @entity7 . The laboratory examination indicated mild @entity5 . Plain and enhanced computed tomography (CT) scans showed a large, dumbbell-shaped, soft-tissue mass of 4.1cm*9.3cm in the curved lumen of the descending colon near the spleen. After enhancement, the lesion presented with progressive and uneven enhancement. The boundary between the lesion and parts of the left kidney and spleen was obscured. A small amount of exudation was observed around the lumen, and a slightly enlarged lymph node shadow was observed in the mesangial gap.After each preoperative examination was completed, the @entity1 invading the spleen and left kidney were excised. Based on the surgical specimen pathological histology and immunohistochemistry, epithelioid inflammatory @entity3 was diagnosed. @entity1 recurrence occurred a short time after excision.EIMS in the abdominal cavity could occur on the intestinal wall, occasionally manifesting as large masses that expand to the inside and the outside of the cavity. It needs to be distinguished from other @entity1 . @entity1 recurrence can easily occur after surgery. @entity9 ( @entity9 ) inhibitors are a potential alternative treatment option.

title: Incomplete Intestinal Obstruction Caused by a Rare Epithelioid Inflammatory Myofibroblastic XXXX : A Case Report.

answer: @entity7


abstract: UNASSIGNED: The aims of this study were to evaluate factors influencing the distribution of @entity3 in tissue of @entity0 suffering from varying degrees of @entity4 ( @entity4 ). Blood and tissue samples were collected from @entity0 undergoing debridement or amputation procedures and the amount of @entity3 in them was determined using high-performance liquid chromatography. All @entity0 were administered a 200-mg dose of intravenous @entity3 prior to the debridement or amputation procedure. Data, including @entity0 gender, age, type of @entity1 , presence of @entity2 , medications taken, and severity of @entity4 were collected. These data were then analyzed to determine factors influencing the concentrations of @entity3 in tissue of the lower limbs. The Kruskal-Wallis test, Spearman correlation, and chi-square test were used to relate covariates and fixed factors with the concentration of @entity3 in tissue. Following bivariate analysis, a 3-predictor regression model was fitted to predict tissue concentrations of @entity3 given information about these predictors. Blood and tissue samples were collected from 50 @entity0 having an average age of 68 years. Thirty-three @entity0 were males and 35 @entity0 suffered from type 2 @entity1 . The average number of medications that these @entity0 were taking was 10. The majority of @entity0 (n = 35) were suffering from severe @entity4 . Tissue concentrations of @entity3 were mainly related to plasma concentrations of @entity3 , number of medications that the @entity0 were taking and severity of @entity4 .

title: Factors Affecting Penetration of XXXX in Lower Extremity Ischemic Tissues.

answer: @entity3


abstract: BACKGROUND: @entity9 analogues [ @entity10 (FAMP); @entity8 and @entity7 ) and extracorporeal photochemotherapy (ECP) have been suggested to be active agents in advanced @entity2 ( @entity2 ) @entity0 . OBJECTIVES: To explore further the clinical efficacy and safety of FAMP monochemotherapy in advanced @entity2 and to evaluate if the sequential association of ECP to FAMP in selected @entity0 may improve the response rate (RR) and/or lengthen the remission duration. @entity0 AND METHODS: Forty-four @entity2 @entity0 [17 @entity5 ( @entity5 ); 26 @entity4 ( @entity4 ), stage IIB-IV or with peripheral blood involvement; one @entity4 associated with @entity6 ( @entity6 )] were enrolled in this pilot cohort study. All the @entity0 received FAMP 25 mg m(-2) 5 days monthly; 19 @entity0 (43.2%) underwent ECP after FAMP was discontinued. The majority of @entity0 with erythrodermic @entity2 or peripheral blood involvement underwent the combined FAMP-ECP schedule. RESULTS: After a median follow-up of 4.2 years, the overall FAMP RR was 29.5% (13/44); a higher RR was obtained in @entity5 (35.3%) than in @entity4 @entity0 (25.9%). According to the treatment group, the RR of the FAMP-ECP group (63.2%) was significantly higher than that of the FAMP monotherapy group (24%; P=0.021). No statistically significant difference was found in @entity3 ( @entity3 ) or survival by therapy group, even if the @entity3 of the @entity0 treated with the FAMP-ECP combination therapy was higher (median 13 vs. 7 months). A decrease or a normalization in the @entity1 +CD26- circulating subset was observed in responding @entity0 , paralleling the reduction in the circulating S  zary cells. CONCLUSIONS: FAMP confirms its clinical activity as a single agent in @entity5 ; conversely, FAMP results do not compare favourably with other therapeutic approaches for advanced stage @entity4 @entity0 . The sequential association of ECP after FAMP seems to increase the RR, even if future randomized studies are needed to confirm these results.

title: Treatment of advanced @entity4 / XXXX with fludarabine and potential adjunctive benefit to subsequent extracorporeal photochemotherapy.

answer: @entity5


abstract: BACKGROUND: @entity9 analogues [ @entity10 (FAMP); @entity8 and @entity7 ) and extracorporeal photochemotherapy (ECP) have been suggested to be active agents in advanced @entity2 ( @entity2 ) @entity0 . OBJECTIVES: To explore further the clinical efficacy and safety of FAMP monochemotherapy in advanced @entity2 and to evaluate if the sequential association of ECP to FAMP in selected @entity0 may improve the response rate (RR) and/or lengthen the remission duration. @entity0 AND METHODS: Forty-four @entity2 @entity0 [17 @entity5 ( @entity5 ); 26 @entity4 ( @entity4 ), stage IIB-IV or with peripheral blood involvement; one @entity4 associated with @entity6 ( @entity6 )] were enrolled in this pilot cohort study. All the @entity0 received FAMP 25 mg m(-2) 5 days monthly; 19 @entity0 (43.2%) underwent ECP after FAMP was discontinued. The majority of @entity0 with erythrodermic @entity2 or peripheral blood involvement underwent the combined FAMP-ECP schedule. RESULTS: After a median follow-up of 4.2 years, the overall FAMP RR was 29.5% (13/44); a higher RR was obtained in @entity5 (35.3%) than in @entity4 @entity0 (25.9%). According to the treatment group, the RR of the FAMP-ECP group (63.2%) was significantly higher than that of the FAMP monotherapy group (24%; P=0.021). No statistically significant difference was found in @entity3 ( @entity3 ) or survival by therapy group, even if the @entity3 of the @entity0 treated with the FAMP-ECP combination therapy was higher (median 13 vs. 7 months). A decrease or a normalization in the @entity1 +CD26- circulating subset was observed in responding @entity0 , paralleling the reduction in the circulating S  zary cells. CONCLUSIONS: FAMP confirms its clinical activity as a single agent in @entity5 ; conversely, FAMP results do not compare favourably with other therapeutic approaches for advanced stage @entity4 @entity0 . The sequential association of ECP after FAMP seems to increase the RR, even if future randomized studies are needed to confirm these results.

title: Treatment of advanced XXXX / @entity5 with fludarabine and potential adjunctive benefit to subsequent extracorporeal photochemotherapy.

answer: @entity4


abstract: OBJECTIVE: To discuss the feasibility and advantages of aberrant incision location of single-port video-assisted thoracoscopic surgery(VATS) in different gender when treating some @entity5 . METHODS: Retrospectively analyze the clinical data of these @entity0 who were received lung partial resection from the same surgeon in the First Affiliated Hospital of Soochow University, the 100 Hospital of PLA, Wu Zhong @entity0 's Hospital from January 2012 to December 2014. Among the males, 57 were undertook a single-port VATS surgery through areola incision (Observation Group A), and the rest 114 were received conventional uniportal VATS surgery (Control Group A). Among the females, 15 were operated through the subxiphoid incision (Observation Group B) and 45 were received conventional one (Control Group B). The operation time, @entity3 , @entity1 amount, chest tube drainage duration, postoperative hospital stay, the Visual Analogue Scale (VAS) @entity2 score of the 1st and 2nd postoperative day, the incision discomfort in the 30th and 90th postoperative day, and the incision satisfaction degree were evaluated. RESULTS: All the @entity0 were underwent total VATS surgery successfully and no severe complications were observed.In males, there were no significant differences in operation time, @entity3 , @entity1 amount, chest tube drainage duration, postoperative hospital day and the VAS score of the 1st postoperative day (P>0.05). Compared to control group A, the VAS score of the 2nd postoperative day was lower (3.56  1.78 vs 4.14  1.62, P=0.035), the incision discomfort of 30th and 90th postoperative day was reduced (33(57.9%) vs 86(75.4%), P=0.019; 29(50.9%) vs 76(66.7%), P=0.046) and the incision satisfaction degree was significantly improved (45(79.0%) vs 61(53.5%), P=0.001). In females, there were no statistical differences in intraoperative @entity3 , @entity1 amount, chest tube drainage duration, postoperative hospital day and the incision satisfaction degree (P>0.05). Compared to control group B, the operation time was obviously prolonged (57.67  5.72 vs 42.91  7.82, P=0.000), the VAS score of the 1st and 2nd postoperative day was significantly lower (2.13  1.06 vs 3.84  1.69, P=0.001; 2.60  1.24 vs 4.18  1.56, P=0.001) and the incision discomfort in 30th and 90th postoperative day was reduced (4(26.7%) vs 34(75.6%), P=0.001; 4(26.7%) vs 28(62.2%), P=0.017). CONCLUSION: In single-port VATS surgery for some @entity5 , we choose "individualized" incision location--trans-areola incision in males and subxiphoid incision in females--according to different gender and varieties of diseases, which was considered to raise incision satisfaction degree in males and reduce @entity4 in females, it warrants further clinical practice.

title: [Single-port VATS resection for some XXXX :strategies of the incision location in different gender].

answer: @entity5


abstract: The @entity0 At filamentation temperature sensitive (FtsH) metalloprotease gene family comprises 12 members ( @entity3 -AtFtsH12), including three pairs of closely related genes that are targeted to chloroplasts ( @entity1 and @entity4 ; @entity3 and @entity2 ; and @entity5 and @entity6 ). Mutations in @entity2 ( @entity2 ) and @entity1 ( @entity1 ) give rise to variegated plants with green- and white-sectored leaves. Cells in the green sectors contain morphologically normal chloroplasts, whereas cells in the white sectors are blocked in chloroplast biogenesis. A major question is how chloroplasts arise in cells that have a mutant genotype. We have found by two-dimensional (2-D) green gel and gel filtration analyses that @entity1 / @entity1 forms oligomeric complexes. Two bands in the 2-D green gels that correspond to @entity2 / @entity2 + @entity3 and @entity1 / @entity1 + @entity4 have been identified, and these bands are coordinately reduced in amount in @entity2 and @entity1 thylakoids that lack @entity2 / @entity2 and @entity1 / @entity1 , respectively. These reductions are not because of alterations in transcript abundance. Overexpression of @entity4 in @entity1 -4 (a putative null allele) normalizes the variegation phenotype of the mutant and restores the two bands to their wild-type levels. These results suggest that @entity4 is interchangeable with @entity1 / @entity1 in AtFtsH-containing oligomers, and that the two proteins have redundant functions. Consistent with this hypothesis, @entity1 and @entity4 have similar expression patterns, as monitored by promoter-beta-glucuronidase (GUS) fusion and RT-PCR experiments. Based on our findings, we propose that @entity3 , @entity1 / @entity1 , @entity2 / @entity2 , and @entity4 interact to form oligomeric structures, and that subunit stoichiometry is controlled post-transcriptionally in @entity2 and @entity1 , perhaps by turnover. A threshold model is presented to explain the pattern of variegation in @entity1 in which @entity4 provides a compensating activity in the green sectors of the mutant.

title: The XXXX FtsH metalloprotease gene family: interchangeability of subunits in chloroplast oligomeric complexes.

answer: @entity0


abstract: @entity4 ( @entity4 ) is an anti-inflammatory cytokine, which active form is a non-covalent homodimer. Given the potential of @entity4 for application in various medical conditions, it is essential to develop systems for its effective delivery. In previous work, it has been shown that a dextrin nanogel effectively incorporated and stabilized @entity5 , enabling its release over time. In this work, the delivery system based on dextrin nanogels was further analyzed. The biocompatibility of the nanogel was comprehensively analyzed, through @entity1 ( @entity3 dehydrogenase (LDH) release, MTS, Live, and Dead) and genotoxicity (comet) assays. The release profile of @entity5 and its biological activity were evaluated in vivo, using C57BL/6 @entity0 . Although able to maintain a stable concentration of @entity4 for at least 4 h in mice serum, the amount of protein released was rather low. Despite this, the amount of @entity5 released from the complex was biologically active inhibiting @entity2 production, in vivo, by LPS-challenged @entity0 . In spite of the significant stabilization achieved using the nanogel, @entity5 still denatures rather quickly. An additional effort is thus necessary to develop an effective delivery system for this cytokine, able to release active protein over longer periods of time. Nevertheless, the good biocompatibility, the protein stabilization effect and the ability to perform as a carrier with controlled release suggest that self-assembled dextrin nanogels may be useful protein delivery systems.

title: Self-assembled dextrin nanogel as protein carrier: controlled release and biological activity of XXXX .

answer: @entity4


abstract: BACKGROUND: Obstructive sleep @entity4 is characterised by repeated episodes of pauses in breathing during sleep due to obstruction of the upper airway that result in transient hypoxaemia, @entity5 and long-term @entity3 . The most common risk factors for @entity1 include: @entity2 , age over 50 and neck circumference of more than 41 cm for females and more than 43 cm in males. Sleep @entity4 is more common in @entity0 than in @entity0 . The aim of the conducted research was to evaluate relations between the anthropometric features connected with adipose tissue distribution and the severity of @entity1 . MATERIAL AND METHODS: The study was carried out on 180 @entity0 (144 males and 36 females) diagnosed with @entity1 ( @entity1 ). The standard sleep parameters obtained from night polisomnography as well as skin-fat fold thickness and neck circumference and waist-to-hip ratio were analysed. Statistical analysis was performed using STATISTICA 10. RESULTS: It was stated that anthropometric parameters connected with the accumulation of adipose tissue in upper body were significantly related to severity of @entity1 in males (P <=0.05). BMI was significantly correlated with severity of @entity1 in females (P <=0.05). CONCLUSIONS: in males, there is a connection between the severity of @entity1 , BMI and a higher accumulation of adipose tissue in upper part of the body measured by neck circumference and shoulder thickness of skin-fat folds, whereas in females only by BMI.

title: Anthropometric and physiologic assessment in sleep XXXX @entity0 regarding body fat distribution.

answer: @entity4