abstract: This study aims to evaluate clinical efficacy of short segment pedicle screw fixation without bone fusion for unstable thoracolumbar burst @entity2 . Nineteen @entity0 younger than 40 years old with unstable thoracolumbar burst @entity2 were included. The surgical procedure included postural reduction for 3 days and screw fixations at one level above, one level below and at the fractured level itself. The implants were removed 12 months after initial operation. Imaging and clinical findings were analyzed at preoperative, 12 months after surgery, just before implant removal, and at six months after implant removal. Results indicated that difference was statistically significant between preoperative period or postoperative 1 year follow-up, just before implant removal and 6 months after implant removal (P < 0.05). Results at postoperative 1 year follow-up, just before implant removal and 6 months after implant removal were better than preoperative period. There were no significant complications or @entity1 after screws insert and removal in any @entity0 . The rate of clinical outcome with excellent and good was 94.7%. In conclusion, short segment pedicle screw fixation without bone fusion can be an effective and safe operative srategytechnique in the management of young @entity0 suffering from unstable burst @entity2 .

title: Short segment screw fixation without fusion in treatment for unstable thoracolumbar burst XXXX .

answer: @entity2


abstract: We recently experienced two @entity0 with @entity2 -like symptoms and ascending @entity10 (AAD) in our outpatient department. Both @entity0 were transferred to our hospital presenting with @entity1 such as @entity9 and conjugate deviation. They did not complain from any chest or @entity5 . Their MRI did not show fresh @entity8 or main @entity7 . A chest CT image showed AAD. The former @entity0 was immediately transferred to a tertiary hospital and the latter received conservative management in the cardiovascular department. Discussion. As neither @entity0 was experiencing any @entity3 , we initially diagnosed them with @entity4 and began treatment. Fortunately, @entity6 complications did not occur. In such cases, problems are caused when intravenous @entity11 ) injection is administered with the aim of reopening the occluded intracranial arteries. In fact, @entity0 with AAD undergoing t-PA injection have been reported to die from @entity6 complications without any recognition of the dissection. These findings suggest that confirmation using carotid ultrasound, carotid MR angiography, and a D-dimer test is crucial and should be adopted in emergency departments.

title: Consideration of two cases of ascending @entity10 that began with XXXX -like symptoms.

answer: @entity2


abstract: We recently experienced two @entity0 with @entity2 -like symptoms and ascending @entity10 (AAD) in our outpatient department. Both @entity0 were transferred to our hospital presenting with @entity1 such as @entity9 and conjugate deviation. They did not complain from any chest or @entity5 . Their MRI did not show fresh @entity8 or main @entity7 . A chest CT image showed AAD. The former @entity0 was immediately transferred to a tertiary hospital and the latter received conservative management in the cardiovascular department. Discussion. As neither @entity0 was experiencing any @entity3 , we initially diagnosed them with @entity4 and began treatment. Fortunately, @entity6 complications did not occur. In such cases, problems are caused when intravenous @entity11 ) injection is administered with the aim of reopening the occluded intracranial arteries. In fact, @entity0 with AAD undergoing t-PA injection have been reported to die from @entity6 complications without any recognition of the dissection. These findings suggest that confirmation using carotid ultrasound, carotid MR angiography, and a D-dimer test is crucial and should be adopted in emergency departments.

title: Consideration of two cases of ascending XXXX that began with @entity2 -like symptoms.

answer: @entity10


abstract: OBJECTIVE: Compare the efficacy of surrogate or gestational carrier (GC) cycles to that of autologous @entity2 ( @entity2 )/intracytoplasmic sperm injections (ICSI) in @entity0 with gynecologic or medical co-morbidities contraindicative to pregnancy. DESIGN: Retrospective cohort study. SETTING: @entity5 @entity0 from a single university hospital-based program from 1998-2009. INTERVENTIONS: 128 GC cycles from 80 intended parents were identified and compared with 15,311 @entity2 or ICSI cycles. MAIN OUTCOME MEASURES: The peak @entity3 (E2), number of oocytes retrieved, cycle cancellation, ongoing pregnancy, and live-birth were compared between GCs and autologous @entity2 carriers. Indications for GC use were also identified. Multiple cycles contributed by the same @entity0 were accounted for using multivariable generalized estimating equations and two-sided Wald p-values. RESULTS: Uterine factors (67%) was the most common indication for using a GC, followed by non-gynecologic medical conditions including @entity7 (13%), @entity6 (10%), @entity4 (5%) and @entity1 (5%). Adjusting for age, ovulation induction in GC cycles had similar peak E2 levels and number of oocytes retrieved relative to @entity2 cycles (p = 0.23 and 0.43, respectively). Clinical pregnancy (49% vs. 42%, p = 0.28) and live-birth rates (31% vs. 32%, p = 0.74) were also comparable. A sub-analysis of GC cycles in those @entity0 with uterine factor indications, demonstrated significantly higher clinical pregnancy rates (OR = 2.0; CI = 1.2 - 3.5) with 60% greater odds of live-birth relative to @entity2 /ICSI cycles, however this odds was not statistically significant for differences in live-birth (CI = 0.9 - 2.9). Conclusions: GCs are a viable alternative to start families for @entity0 with medical co-morbidities precluding pregnancy.

title: Gestational carriers: A viable alternative for XXXX with medical contraindications to pregnancy.

answer: @entity0


abstract: A study is reported which tries to identify those members of the general population who may be at increased risk of @entity2 . It is probable that @entity0 who have had previous @entity6 episodes are inherently more at risk of further episodes and that a @entity6 many months ago will not affect current tests. Accordingly we carried out a number of tests involving platelets on 'controls', and on @entity0 with a past history of either @entity4 or @entity7 ( @entity7 ) and @entity0 suffering from @entity5 who also are assumed to be at higher risk than the controls. Differences were demonstrated between controls and @entity0 groups and these differences were utilized to develop statistical functions with the ability to discriminate between the groups. The functions were then tested using a second set of data from similar groups. Those designed to discriminate between @entity4 @entity0 and controls and between @entity0 with @entity5 and controls were validated. The heparin @entity3 clotting time was found to be the prime predictor variable; the platelet count, platelet volume, platelet factor 3 clotting time and the bleeding time have some predictive value. The @entity9 clotting time, @entity8 and platelet adhesiveness tests as measured were not found to have discriminating potential. It is suggested that these appropriate risk functions could be of practical value in identifying members of the general population who may be at greater risk than average. The discriminate functions for @entity7 @entity0 and controls could not be validated, suggesting differences in platelet involvement in arterial and @entity1 .

title: Platelets in the prediction of XXXX risk.

answer: @entity6


abstract: PURPOSE: To study the demographic characteristics of @entity4 in Central Sarawak and identify the determinant factors of poor visual outcome. DESIGN: A retrospective study of @entity4 cases presenting at the referral hospital in 2013. METHODS: @entity0 were identified and recruited from hospital records. Those presenting for follow-up review were excluded. Case records were retrieved and reviewed after recruitment. RESULTS: We studied 168 @entity0 with 179 @entity5 , of which 44% were work related. Compared with non-work-related cases, work-related cases were more likely to be male [odds ratio (OR), 19.7; 95% confidence interval (CI), 2.6-150.9] and foreign (OR, 18.0; 95% CI, 2.3-142.0). @entity3 constituted a higher percentage of @entity2 (VA) during the first visit: 84.6% compared with 18.1% for closed @entity1 (OR, 25.0; 95% CI, 5.3-118.4; P < 0.001). Of the @entity3 , 61.5% worsened or showed no improvement in VA after 3 months compared with closed @entity1 (28.9%) (OR, 3.9; 95% CI, 1.2-12.7; P = 0.015). Of cases presenting 7 or more days after @entity1 , 76.9% worsened or showed no improvement in VA after 3 months compared with those presenting in less than 7 days (27.7%) (OR, 8.7; 95% CI, 2.3-33.0; P < 0.001). Among those with work-related injuries, 23.1% had used eye protective devices (EPDs). CONCLUSIONS: @entity5 in Central Sarawak were predominantly work related, occurring at industrial premises, and involving males and foreigners. Both @entity3 and a delay in seeking treatment resulted in significantly poorer visual outcomes.

title: Determinant Factors of Poor Visual Outcome After XXXX : A Retrospective Study in Central Sarawak, Malaysia.

answer: @entity4


abstract: UNASSIGNED: The sensitivity of @entity3 mRNA-based Aptima HPV test (AHPV; Hologic Inc) for detection of cervical @entity1 has been reported based on only a small number of cases. We determined the sensitivity of AHPV in comparison with the DNA-based Hybrid Capture 2 HPV test ( @entity2 ; Qiagen) for the detection of oncogenic HPV in a large number of @entity1 at the time of diagnosis using cervical samples obtained in ThinPrep (Hologic). Samples yielding discordant results were genotyped using Linear Array assay (LA; Roche). Of 396 cases tested, AHPV detected 377 (sensitivity, 95.2%; 95% CI: 93.1 - 97.3), and @entity2 376 (sensitivity, 94.9%; 95% CI: 92.7 - 97.1) with an agreement of 97.2% (kappa 0.7; 95% CI: 0.54-0.87). Among six AHPV   +   / @entity2 - cases, LA identified oncogenic HPV types in four including a type 73 and was negative in two. Among five AHPV-/ @entity2 + cases, LA detected oncogenic HPV types in two including a type 73 and was negative in three. Of 14 AHPV-/ @entity2 - cases, 13 were genotyped. LA detected oncogenic HPV types in six, non-oncogenic types in three, and was negative in four. This is the largest study to demonstrate the sensitivity of AHPV for the detection of @entity0 and this assay showed equal sensitivity to @entity2 . This article is protected by copyright. All rights reserved.

title: Sensitivity of APTIMA HPV @entity3 mRNA test in comparison with hybrid capture 2 HPV DNA test for detection of high risk oncogenic human papillomavirus in 396 biopsy confirmed XXXX .

answer: @entity1


abstract: UNASSIGNED: The sensitivity of @entity3 mRNA-based Aptima HPV test (AHPV; Hologic Inc) for detection of cervical @entity1 has been reported based on only a small number of cases. We determined the sensitivity of AHPV in comparison with the DNA-based Hybrid Capture 2 HPV test ( @entity2 ; Qiagen) for the detection of oncogenic HPV in a large number of @entity1 at the time of diagnosis using cervical samples obtained in ThinPrep (Hologic). Samples yielding discordant results were genotyped using Linear Array assay (LA; Roche). Of 396 cases tested, AHPV detected 377 (sensitivity, 95.2%; 95% CI: 93.1 - 97.3), and @entity2 376 (sensitivity, 94.9%; 95% CI: 92.7 - 97.1) with an agreement of 97.2% (kappa 0.7; 95% CI: 0.54-0.87). Among six AHPV   +   / @entity2 - cases, LA identified oncogenic HPV types in four including a type 73 and was negative in two. Among five AHPV-/ @entity2 + cases, LA detected oncogenic HPV types in two including a type 73 and was negative in three. Of 14 AHPV-/ @entity2 - cases, 13 were genotyped. LA detected oncogenic HPV types in six, non-oncogenic types in three, and was negative in four. This is the largest study to demonstrate the sensitivity of AHPV for the detection of @entity0 and this assay showed equal sensitivity to @entity2 . This article is protected by copyright. All rights reserved.

title: Sensitivity of APTIMA HPV XXXX mRNA test in comparison with hybrid capture 2 HPV DNA test for detection of high risk oncogenic human papillomavirus in 396 biopsy confirmed @entity1 .

answer: @entity3


abstract: UNASSIGNED: Complement inhibitors have not been thoroughly evaluated in the treatment of acute antibody-mediated rejection (ABMR). We performed a prospective, single-arm pilot study to investigate the potential effects and safety of @entity3 ( @entity4 ) Berinert added to high-dose intravenous immunoglobulin (IVIG) for the treatment of acute ABMR that is nonresponsive to conventional therapy. Kidney recipients with nonresponsive active ABMR and acute allograft dysfunction were enrolled between April 2013 and July 2014 and received @entity4 and IVIG for 6 months (six @entity0 ). The primary end point was the change in @entity1 at 6 months after inclusion (M+6). Secondary end points included the changes in histology and DSA characteristics and adverse events as evaluated at M+6. All @entity0 showed an improvement in @entity1 between inclusion and M+6: from 38.7    17.9 to 45.2    21.3 mL/min/1.73 m(2) (p = 0.0277). There was no change in histological features, except a decrease in the C4d deposition rate from 5/6 to 1/6 (p = 0.0455). There was a change in DSA C1q status from 6/6 to 1/6 positive (p = 0.0253). One @entity2 was observed. In a secondary analysis, C1- @entity3 @entity0 were compared with a similar historical control group (21 @entity0 ). @entity4 added to IVIG is safe and may improve allograft function in kidney recipients with nonresponsive acute ABMR.

title: XXXX in Acute Antibody-Mediated Rejection Nonresponsive to Conventional Therapy in Kidney Transplant Recipients: A Pilot Study.

answer: @entity3


abstract: BACKGROUND: The anesthetic management of @entity0 undergoing endovascular treatment of @entity1 in the interventional neuroradiology suite can be challenged by @entity2 because of low ambient temperature for operating and maintaining its equipments. We evaluated the efficacy of skin surface warming prior to induction of anesthesia to prevent the decrease in core temperature and reduce the incidence of @entity2 . METHODS: Seventy-two @entity0 were randomized to pre-warmed and control group. The @entity0 in pre-warmed group were warmed 30  minutes before induction with a forced-air warming blanket set at 38  C. Pre-induction tympanic temperature (Tpre) was measured using an infrared tympanic thermometer and core temperature was measured at the esophagus immediately after intubation (T0) and recorded at 20  minutes intervals (T20, T40, T60, T80, T100, and T120). The number of @entity0 who became hypothermic at each time was recorded. RESULTS: Tpre in the control and pre-warmed group were 36.4        0.4  C and 36.6        0.3  C, whereas T0 were 36.5        0.4  C and 36.6        0.2  C. Core temperatures in the pre-warmed group were significantly higher than the control group at T20, T40, T60, T80, T100, and T120 (P   <   0.001). Compared to T0, core temperatures at each time were significantly lower in both two groups (P   =   0.007 at T20 in pre-warmed group, P   <   0.001 at the other times in both groups). The incidence of @entity2 was significantly lower in the pre-warmed group than the control group from T20 to T120 (P   =   0.002 at T20, P   <   0.001 at the other times). CONCLUSION: Pre-warming for 30  minutes at 38  C did not modify the trends of the temperature decrease seen in the INR suite. It just slightly elevated the beginning post intubation base temperature. The rate of decrease was similar from T20 to T120. However, pre-warming considerably reduced the risk of intraprocedural @entity2 . TRIAL REGISTRATION: Clinical Research Information Service (CRiS) Identifier: KCT0001320. Registered December 19th, 2014.

title: The efficacy of pre-warming on reducing intraprocedural XXXX in endovascular coiling of @entity1 .

answer: @entity2


abstract: BACKGROUND: The anesthetic management of @entity0 undergoing endovascular treatment of @entity1 in the interventional neuroradiology suite can be challenged by @entity2 because of low ambient temperature for operating and maintaining its equipments. We evaluated the efficacy of skin surface warming prior to induction of anesthesia to prevent the decrease in core temperature and reduce the incidence of @entity2 . METHODS: Seventy-two @entity0 were randomized to pre-warmed and control group. The @entity0 in pre-warmed group were warmed 30  minutes before induction with a forced-air warming blanket set at 38  C. Pre-induction tympanic temperature (Tpre) was measured using an infrared tympanic thermometer and core temperature was measured at the esophagus immediately after intubation (T0) and recorded at 20  minutes intervals (T20, T40, T60, T80, T100, and T120). The number of @entity0 who became hypothermic at each time was recorded. RESULTS: Tpre in the control and pre-warmed group were 36.4        0.4  C and 36.6        0.3  C, whereas T0 were 36.5        0.4  C and 36.6        0.2  C. Core temperatures in the pre-warmed group were significantly higher than the control group at T20, T40, T60, T80, T100, and T120 (P   <   0.001). Compared to T0, core temperatures at each time were significantly lower in both two groups (P   =   0.007 at T20 in pre-warmed group, P   <   0.001 at the other times in both groups). The incidence of @entity2 was significantly lower in the pre-warmed group than the control group from T20 to T120 (P   =   0.002 at T20, P   <   0.001 at the other times). CONCLUSION: Pre-warming for 30  minutes at 38  C did not modify the trends of the temperature decrease seen in the INR suite. It just slightly elevated the beginning post intubation base temperature. The rate of decrease was similar from T20 to T120. However, pre-warming considerably reduced the risk of intraprocedural @entity2 . TRIAL REGISTRATION: Clinical Research Information Service (CRiS) Identifier: KCT0001320. Registered December 19th, 2014.

title: The efficacy of pre-warming on reducing intraprocedural @entity2 in endovascular coiling of XXXX .

answer: @entity1


abstract: Shiga toxin-producing @entity1 O157:H7 (O157) are significant foodborne pathogens and pose a serious threat to public health worldwide. The major reservoirs of O157 are asymptomatic @entity0 which harbor the organism in the terminal recto-anal junction (RAJ). Some colonized animals, referred to as "super-shedders" ( @entity5 ), are known to shed O157 in exceptionally large numbers (>104 CFU/g of feces). Recent studies suggest that @entity5 @entity0 play a major role in the prevalence and transmission of O157, but little is known about the molecular mechanisms associated with super-shedding. Whole genome sequence analysis of an @entity5 O157 strain (SS17) revealed a genome of 5,523,849 bp chromosome with 5,430 open reading frames and two plasmids, pO157 and pSS17, of 94,645 bp and 37,446 bp, respectively. Comparative analyses showed that SS17 is clustered with @entity3 -associated O157 outbreak strains, and belongs to the lineage I/II, clade 8, D group, and genotype 1, a subgroup of O157 with predicted @entity4 . A large number of non-synonymous SNPs and other polymorphisms were identified in SS17 as compared with other O157 strains (EC4115, EDL933, Sakai, TW14359), including in key adherence- and virulence-related loci. Phenotypic analyses revealed a distinctive and strongly adherent aggregative phenotype of SS17 on @entity0 @entity2 ( @entity2 ) cells that was conserved amongst other @entity5 isolates. Molecular genetic and functional analyses of defined mutants of SS17 suggested that the strongly adherent aggregative phenotype amongst @entity5 isolates is LEE-independent, and likely results from a novel mechanism. Taken together, our study provides a rational framework for investigating the molecular mechanisms associated with @entity5 , and strong evidence that @entity5 O157 isolates have distinctive features and use a LEE-independent mechanism for hyper-adherence to @entity0 rectal epithelial cells.

title: Comparative Analysis of Super-Shedder Strains of XXXX O157:H7 Reveals Distinctive Genomic Features and a Strongly Aggregative Adherent Phenotype on @entity0 Rectoanal Junction Squamous Epithelial Cells.

answer: @entity1


abstract: Shiga toxin-producing @entity1 O157:H7 (O157) are significant foodborne pathogens and pose a serious threat to public health worldwide. The major reservoirs of O157 are asymptomatic @entity0 which harbor the organism in the terminal recto-anal junction (RAJ). Some colonized animals, referred to as "super-shedders" ( @entity5 ), are known to shed O157 in exceptionally large numbers (>104 CFU/g of feces). Recent studies suggest that @entity5 @entity0 play a major role in the prevalence and transmission of O157, but little is known about the molecular mechanisms associated with super-shedding. Whole genome sequence analysis of an @entity5 O157 strain (SS17) revealed a genome of 5,523,849 bp chromosome with 5,430 open reading frames and two plasmids, pO157 and pSS17, of 94,645 bp and 37,446 bp, respectively. Comparative analyses showed that SS17 is clustered with @entity3 -associated O157 outbreak strains, and belongs to the lineage I/II, clade 8, D group, and genotype 1, a subgroup of O157 with predicted @entity4 . A large number of non-synonymous SNPs and other polymorphisms were identified in SS17 as compared with other O157 strains (EC4115, EDL933, Sakai, TW14359), including in key adherence- and virulence-related loci. Phenotypic analyses revealed a distinctive and strongly adherent aggregative phenotype of SS17 on @entity0 @entity2 ( @entity2 ) cells that was conserved amongst other @entity5 isolates. Molecular genetic and functional analyses of defined mutants of SS17 suggested that the strongly adherent aggregative phenotype amongst @entity5 isolates is LEE-independent, and likely results from a novel mechanism. Taken together, our study provides a rational framework for investigating the molecular mechanisms associated with @entity5 , and strong evidence that @entity5 O157 isolates have distinctive features and use a LEE-independent mechanism for hyper-adherence to @entity0 rectal epithelial cells.

title: Comparative Analysis of Super-Shedder Strains of @entity1 O157:H7 Reveals Distinctive Genomic Features and a Strongly Aggregative Adherent Phenotype on XXXX Rectoanal Junction Squamous Epithelial Cells.

answer: @entity0


abstract: AIM: We have previously reported that early phase (1   week) of experimental @entity5 ( @entity5 ) has an adaptive phenotype while wall stress-matched pressure overload (PO) is maladaptive. Here we investigate the transition from adaptation to @entity4 ( @entity4 ) in long-term @entity5 . METHODS AND RESULTS: FVB/N wild-type @entity0 were subjected to @entity5 induced by aortocaval shunt, and were followed by serial echocardiography until in vivo left ventricular ejection fraction was below <50% (135        35   days). @entity4 was evident from increased lung and liver weight and increased mortality compared with sham. Maladaptive remodelling resulted in significantly reduced sarcomeric @entity7 phosphorylation (causing increased sarcomeric stiffness), whereas @entity1 was not increased. This was paralleled by re-expression of the fetal gene program, activation of @entity3 /calmodulin-dependent protein kinase II (CaMKII), decreased protein kinase B ( @entity6 ) phosphorylation, high oxidative stress, and increased apoptosis. Consistently, development of @entity4 and mortality were significantly aggravated in @entity6 -deficient @entity0 . CONCLUSION: Transition to @entity4 in @entity5 is associated with decreased @entity6 and increased CaMKII signalling pathways together with increased oxidative stress and apoptosis. Lack of @entity1 together with sarcomeric @entity7 hypophosphorylation indicates an increased stiffness at the sarcomeric but not matrix level in @entity5 -induced @entity4 (in contrast to PO). Transition to @entity4 may result from myocyte loss and @entity2 owing to increased stiffness.

title: Molecular and structural transition mechanisms in long-term XXXX .

answer: @entity5


abstract: BACKGROUND: Nodal staging is crucial in determining the use of adjuvant chemotherapy for @entity3 . The number of metastatic lymph nodes has been positively correlated with the number of lymph nodes examined. Current guidelines recommend that at minimum 12 to 14 lymph nodes be assessed. In some studies, @entity4 has been associated with lymph node yield. OBJECTIVE: The purpose of this work was to determine whether mismatch repair-deficient @entity2 are associated with increased lymph node yield. DESIGN: We queried an institutional database to analyze colectomy specimens with immunohistochemistry for mismatch repair genes in @entity0 treated for @entity2 between 1999 and 2012. Before 2006, immunohistochemistry was performed at the request of an oncologist or surgeon. After 2006, it was routinely performed for @entity0 <50 years of age. We measured the association of clinical and pathologic features with lymph node quantity. Fourteen predictors and confounders were jointly analyzed in a multivariable linear regression model. SETTINGS: The study was conducted at a single tertiary care institution. @entity0 : Tissue specimens from 256 @entity0 were reviewed. MAIN OUTCOME MEASURES: The correlation of @entity1 , @entity0 , and operative variables to the yield of mesenteric lymph nodes was measured. RESULTS: Of 256 colectomy specimens reviewed, 94 had @entity4 . On univariate analysis, @entity4 was associated with lower lymph node yield, older @entity0 age, right-sided @entity1 , and poor differentiation. The linear regression model identified 5 variables with independent relationships to lymph node yield, including @entity0 age, specimen length, lymph node ratio, perineural invasion, and @entity1 size. A positive correlation was observed with @entity1 size, specimen length, and perineural invasion. @entity1 location had a more complex, nonlinear, quadratic relationship with lymph node yield; proximal @entity1 were associated with a higher yield than more distal lesions. @entity4 was not independently associated with lymph node yield. LIMITATIONS: Mismatch repair immunohistochemistry based on @entity0 age, family history, and pathologic features may reduce the generalizability of these results. Our sample size was too small to identify variables with small measures of effect. The retrospective nature of the study did not permit a true assessment of the extent of mesenteric resection. CONCLUSIONS: @entity0 age, length of bowel resected, lymph node ratio, perineural invasion, @entity1 size, and @entity1 location were significant predictors of lymph node yield. However, when controlling for surgical and pathologic factors, mismatch repair protein expression did not predict lymph node yield.

title: Lymph node yield after colectomy for XXXX : is absence of mismatch repair a factor?

answer: @entity1


abstract: BACKGROUND: Colonic stenting has failed to show an improvement in mortality rates in comparison with emergency surgery for @entity2 . However, it remains unclear which @entity0 are more likely to benefit from this procedure. OBJECTIVE: The aim of this study is to identify factors that may be predictive of successful outcome of colonic stenting in @entity2 . DESIGN: All @entity0 undergoing colonic stenting for @entity2 between 1999 and 2013 were studied. The demographics and characteristics of the obstructing lesion were analyzed. SETTINGS: This investigation was conducted at a district general hospital. @entity0 : A total of 126 (76 @entity0 ; median age, 76 y; range, 42-94 y) with @entity2 were included in the analysis. INTERVENTION: The insertion of a self-expanding metal stent was attempted for each @entity0 to relieve the obstruction. MAIN OUTCOME MEASURES: The primary outcomes measured were technical success in the deployment of the stent, clinical decompression, and perforation rates. RESULTS: Technical deployment of the stent was accomplished in 108 of 126 (86%) @entity0 ; however, only 89 (70%) achieved clinical decompression. Successful deployment and clinical decompression was associated with @entity1 (p = 0.03), shorter strictures (p = 0.01), and wider angulation distal to the obstruction (p = 0.049). Perforation was associated with longer strictures (p = 0.03) LIMITATIONS:: This study was limited by its retrospective nature. CONCLUSION: Colonic stenting in @entity2 is more likely to be successful in shorter, malignant strictures with less angulation distal to the obstruction. Longer benign strictures are less likely to be successful and may be associated with an increased risk of perforation.

title: Predictive factors for successful colonic stenting in XXXX : a 15-year cohort analysis.

answer: @entity2


abstract: UNASSIGNED: @entity1 is the second most prevalent @entity2 . Spinal metastases are found in 30-90% of @entity0 with @entity4 attributed to @entity2 . Due to bony destruction caused by metastases, surgical intervention is often required to restore spinal alignment and stability. While some research suggests that @entity7 may possess tumorigenic effects, other studies show possible inhibition of @entity2 growth. Thirty-six athymic @entity3 underwent intraosseous injection of lung @entity5 cells into the L5 vertebral body. Cells were pre-treated with vehicle control (Group A) or rhBMP-2 (Group B) prior to implantation. At 4 weeks post-implantation, in vivo bioluminescent imaging (BLI) was performed to confirm presence of @entity2 and quantify signal. Plain radiographs and microComputed Tomography (microCT) were employed to establish and quantitate osteolysis. Histological analysis characterized pathologic changes in the vertebral body. At 4 weeks post-implantation, BLI showed focal signal in the L5 vertebral body in 93% of Group A animals and 89% of Group B animals. Average @entity2 burden by BLI radiance was 7.43   *   10(3) p/s/cm(2) /sr (Group A) and 1.11   *   10(4) p/s/cm(2) /sr (Group B). Radiographs and microCT demonstrated osteolysis in 100% of animals showing focal BLI signal. MicroCT demonstrated significant @entity6 in both groups compared to age-matched controls but no difference between study groups. Histological analysis confirmed @entity2 invasion in the L5 vertebral body. These findings provide a reliable in vivo model to study isolated spinal metastases from @entity1 . Statement of Clinical Significance: The data support the notion that exposure to rhBMP-2 does not promote the growth of A549 @entity1 spine lesions. This article is protected by copyright. All rights reserved.

title: The effect of recombinant @entity0 @entity7 on a novel XXXX spine metastasis model in rodents.

answer: @entity1


abstract: UNASSIGNED: @entity1 is the second most prevalent @entity2 . Spinal metastases are found in 30-90% of @entity0 with @entity4 attributed to @entity2 . Due to bony destruction caused by metastases, surgical intervention is often required to restore spinal alignment and stability. While some research suggests that @entity7 may possess tumorigenic effects, other studies show possible inhibition of @entity2 growth. Thirty-six athymic @entity3 underwent intraosseous injection of lung @entity5 cells into the L5 vertebral body. Cells were pre-treated with vehicle control (Group A) or rhBMP-2 (Group B) prior to implantation. At 4 weeks post-implantation, in vivo bioluminescent imaging (BLI) was performed to confirm presence of @entity2 and quantify signal. Plain radiographs and microComputed Tomography (microCT) were employed to establish and quantitate osteolysis. Histological analysis characterized pathologic changes in the vertebral body. At 4 weeks post-implantation, BLI showed focal signal in the L5 vertebral body in 93% of Group A animals and 89% of Group B animals. Average @entity2 burden by BLI radiance was 7.43   *   10(3) p/s/cm(2) /sr (Group A) and 1.11   *   10(4) p/s/cm(2) /sr (Group B). Radiographs and microCT demonstrated osteolysis in 100% of animals showing focal BLI signal. MicroCT demonstrated significant @entity6 in both groups compared to age-matched controls but no difference between study groups. Histological analysis confirmed @entity2 invasion in the L5 vertebral body. These findings provide a reliable in vivo model to study isolated spinal metastases from @entity1 . Statement of Clinical Significance: The data support the notion that exposure to rhBMP-2 does not promote the growth of A549 @entity1 spine lesions. This article is protected by copyright. All rights reserved.

title: The effect of recombinant @entity0 XXXX on a novel @entity1 spine metastasis model in rodents.

answer: @entity7


abstract: UNASSIGNED: @entity1 is the second most prevalent @entity2 . Spinal metastases are found in 30-90% of @entity0 with @entity4 attributed to @entity2 . Due to bony destruction caused by metastases, surgical intervention is often required to restore spinal alignment and stability. While some research suggests that @entity7 may possess tumorigenic effects, other studies show possible inhibition of @entity2 growth. Thirty-six athymic @entity3 underwent intraosseous injection of lung @entity5 cells into the L5 vertebral body. Cells were pre-treated with vehicle control (Group A) or rhBMP-2 (Group B) prior to implantation. At 4 weeks post-implantation, in vivo bioluminescent imaging (BLI) was performed to confirm presence of @entity2 and quantify signal. Plain radiographs and microComputed Tomography (microCT) were employed to establish and quantitate osteolysis. Histological analysis characterized pathologic changes in the vertebral body. At 4 weeks post-implantation, BLI showed focal signal in the L5 vertebral body in 93% of Group A animals and 89% of Group B animals. Average @entity2 burden by BLI radiance was 7.43   *   10(3) p/s/cm(2) /sr (Group A) and 1.11   *   10(4) p/s/cm(2) /sr (Group B). Radiographs and microCT demonstrated osteolysis in 100% of animals showing focal BLI signal. MicroCT demonstrated significant @entity6 in both groups compared to age-matched controls but no difference between study groups. Histological analysis confirmed @entity2 invasion in the L5 vertebral body. These findings provide a reliable in vivo model to study isolated spinal metastases from @entity1 . Statement of Clinical Significance: The data support the notion that exposure to rhBMP-2 does not promote the growth of A549 @entity1 spine lesions. This article is protected by copyright. All rights reserved.

title: The effect of recombinant XXXX @entity7 on a novel @entity1 spine metastasis model in rodents.

answer: @entity0


abstract: @entity1 outcomes are improved by protocols for @entity3 , typically activated after physician evaluation at a hospital. Previous analysis suggested that prehospital vital signs contained patterns indicating the presence or absence of @entity3 . In an observational study of adults (aged >= 18 years) transported to level I @entity1 centers by helicopter, we investigated the diagnostic performance of the Automated Processing of the Physiological Registry for Assessment of Injury Severity (APPRAISE) system, a computational platform for real-time analysis of vital signs, for identification of @entity3 in @entity1 @entity0 with explicitly @entity3 . We studied 209 subjects prospectively and 646 retrospectively. In our multivariate analysis, prospective performance was not significantly different from retrospective. The APPRAISE system was 76% sensitive for 24-h packed red blood cells of 9 or more units (95% confidence interval, 59% - 89%) and significantly more sensitive (P < 0.05) than any prehospital Shock Index of 1.4 or higher; sensitivity, 59%; initial systolic blood pressure (SBP) less than 110 mmHg, 50%; and any prehospital SBP less than 90 mmHg, 50%. The APPRAISE specificity for 24-h packed red blood cells of 0 units was 87% (88% for any Shock Index >= 1.4, 88% for initial SBP <110 mmHg, and 90% for any prehospital SBP <90 mmHg). Median APPRAISE hemorrhage notification time was 20 min before arrival at the @entity1 center. In conclusion, APPRAISE identified @entity3 before @entity1 center arrival. En route, this capability could allow medics to focus on direct @entity0 care rather than the monitor and, via advance radio notification, could expedite hospital interventions for @entity0 with substantial @entity2 .

title: Automated analysis of vital signs to identify @entity0 with XXXX before hospital arrival: a feasibility study.

answer: @entity3


abstract: @entity1 outcomes are improved by protocols for @entity3 , typically activated after physician evaluation at a hospital. Previous analysis suggested that prehospital vital signs contained patterns indicating the presence or absence of @entity3 . In an observational study of adults (aged >= 18 years) transported to level I @entity1 centers by helicopter, we investigated the diagnostic performance of the Automated Processing of the Physiological Registry for Assessment of Injury Severity (APPRAISE) system, a computational platform for real-time analysis of vital signs, for identification of @entity3 in @entity1 @entity0 with explicitly @entity3 . We studied 209 subjects prospectively and 646 retrospectively. In our multivariate analysis, prospective performance was not significantly different from retrospective. The APPRAISE system was 76% sensitive for 24-h packed red blood cells of 9 or more units (95% confidence interval, 59% - 89%) and significantly more sensitive (P < 0.05) than any prehospital Shock Index of 1.4 or higher; sensitivity, 59%; initial systolic blood pressure (SBP) less than 110 mmHg, 50%; and any prehospital SBP less than 90 mmHg, 50%. The APPRAISE specificity for 24-h packed red blood cells of 0 units was 87% (88% for any Shock Index >= 1.4, 88% for initial SBP <110 mmHg, and 90% for any prehospital SBP <90 mmHg). Median APPRAISE hemorrhage notification time was 20 min before arrival at the @entity1 center. In conclusion, APPRAISE identified @entity3 before @entity1 center arrival. En route, this capability could allow medics to focus on direct @entity0 care rather than the monitor and, via advance radio notification, could expedite hospital interventions for @entity0 with substantial @entity2 .

title: Automated analysis of vital signs to identify XXXX with @entity3 before hospital arrival: a feasibility study.

answer: @entity0


abstract: INTRODUCTION: @entity1 is a debilitating problem that is not only uncomfortable and inconvenient, but also embarrassing in work and social situations. In spite of the availability of several options for the treatment of axillary @entity1 , recently, there has been an increasing interest in the use of laser therapy. This study aims to evaluate the efficacy of a laser diode device emitting at wavelengths of 924 and 975   nm and classical curettage either alone, simultaneously or in combination. MATERIAL AND METHODS: A randomized prospective controlled trial was carried out on 100 @entity0 divided into four groups, each with a different protocol: Laser alone at 975   nm (group 1), laser alone at 924/975   nm simultaneously (group 2), curettage alone (group 3), and finally laser at 924/975   nm followed by curettage (group 4). HDSS, starch test and GAIS were used to assess treatment efficacy. The follow-up extended to one year. Statistical analysis (SPSS) was used to determine the accuracy of the results. RESULT:: Two @entity0 of group 1 experienced burns during treatment, which took over a month to heal. This group of @entity0 achieved the worst results: The starch test scale results after treatment were 2.48        0.51 and 2.76        0.44 (at 1 and 12 months). The GAIS results were 1.04        0.35 and 0.92        0.28 (1 and 12 months). In group 2 the starch test scale results after treatment were 1.36        0.49 and 1.48        0.51 (at 1 and 12 months). The GAIS results were 2.36        0.49 and 2.72        0.46 (at 1 and 12 months). In group 3, the starch test scale results after treatment were 1.56        0.51 and 1.76        0.60 (at 1 and 12 months), which corresponds to small to substantially smaller dark areas. The GAIS results were 2.28        0.46 and 2.64        0.49 (at 1 and 12 months). The best results were obtained in group 4: HDSS scores were reduced from 3.88        0.33 before treatment to 1.24        0.44 and 0.48        0.51 at the 1 and 12 months controls. The starch test scale results after treatment were 0.40        0.50 and 0.44        0.51 (at 1 and 12 months). The GAIS results were 3.72        0.54 and 3.76        0.44 (at 1 and 12 months). CONCLUSION:: In this study, the laser at 924/975   nm combined with curettage was determined to be the optimal treatment option of those tested for axillary @entity1 . This treatment was safe, with few side effects and improvement that persisted to one year follow-up. Lasers Surg. Med.    2015 Wiley Periodicals, Inc.

title: Efficacy and safety of laser therapy on axillary XXXX after one year follow-up: A randomised blinded controlled trial.

answer: @entity1


abstract: BACKGROUND: Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. @entity4 is associated with worse outcomes in various acute @entity1 . An integrative approach is presently used according to the existing paradigm for the association of series of temporal @entity2 with the outcomes of @entity0 with @entity3 ( @entity3 ). OBJECTIVE: To explore the influence of the duration of @entity2 events on severe @entity3 @entity0 outcomes. @entity0 age was also included in the analysis of the prospectively collected clinical data. METHODS: CA monitoring included 33 prospective severe @entity3 @entity0 . The pressure reactivity index [ @entity5 (t)] was continuously monitored to collect information on the dynamics of CA status and to analyze associations between the duration of the longest @entity2 event and @entity0 outcomes. RESULTS: The Glasgow outcome scale and the duration of the longest @entity2 were negatively correlated. The duration of autoregulation impairment significantly correlated with worse outcomes. Multidimensional representation of Glasgow outcome scale plots showed that better outcomes were obtained for younger @entity0 (age < 47 years) and those whose longest @entity2 event was shorter than 40 minutes if @entity5 (t) was above 0.7 in the @entity2 event. CONCLUSION: Unfavorable outcomes for @entity3 @entity0 are more significantly associated with the duration of the single longest @entity2 episode at a high @entity5 (t) value, rather than with averaged @entity5 (t) values or the average time of all @entity2 episodes. ABBREVIATIONS: ABP, arterial blood pressureABP(t), continuous reference arterial blood pressureCA, cerebrovascular autoregulationCBF, cerebral blood flowCPP, cerebral perfusion pressureGOS, Glasgow outcome scaleGOSHD, Glasgow outcome scale after hospital dischargeGOS6M, Glasgow outcome scale at 6 months after dischargeICP, intracranial pressureICP(t), continuously monitored intracranial pressureLCAI, longest CA impairmentoptCPP, optimal cerebral perfusion pressurePRx(t), pressure reactivity indexTBI, @entity3 .

title: Association of Severe XXXX @entity0 Outcomes With Duration of Cerebrovascular Autoregulation Impairment Events.

answer: @entity3


abstract: BACKGROUND: Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. @entity4 is associated with worse outcomes in various acute @entity1 . An integrative approach is presently used according to the existing paradigm for the association of series of temporal @entity2 with the outcomes of @entity0 with @entity3 ( @entity3 ). OBJECTIVE: To explore the influence of the duration of @entity2 events on severe @entity3 @entity0 outcomes. @entity0 age was also included in the analysis of the prospectively collected clinical data. METHODS: CA monitoring included 33 prospective severe @entity3 @entity0 . The pressure reactivity index [ @entity5 (t)] was continuously monitored to collect information on the dynamics of CA status and to analyze associations between the duration of the longest @entity2 event and @entity0 outcomes. RESULTS: The Glasgow outcome scale and the duration of the longest @entity2 were negatively correlated. The duration of autoregulation impairment significantly correlated with worse outcomes. Multidimensional representation of Glasgow outcome scale plots showed that better outcomes were obtained for younger @entity0 (age < 47 years) and those whose longest @entity2 event was shorter than 40 minutes if @entity5 (t) was above 0.7 in the @entity2 event. CONCLUSION: Unfavorable outcomes for @entity3 @entity0 are more significantly associated with the duration of the single longest @entity2 episode at a high @entity5 (t) value, rather than with averaged @entity5 (t) values or the average time of all @entity2 episodes. ABBREVIATIONS: ABP, arterial blood pressureABP(t), continuous reference arterial blood pressureCA, cerebrovascular autoregulationCBF, cerebral blood flowCPP, cerebral perfusion pressureGOS, Glasgow outcome scaleGOSHD, Glasgow outcome scale after hospital dischargeGOS6M, Glasgow outcome scale at 6 months after dischargeICP, intracranial pressureICP(t), continuously monitored intracranial pressureLCAI, longest CA impairmentoptCPP, optimal cerebral perfusion pressurePRx(t), pressure reactivity indexTBI, @entity3 .

title: Association of Severe @entity3 XXXX Outcomes With Duration of Cerebrovascular Autoregulation Impairment Events.

answer: @entity0


abstract: BACKGROUND: Conventional systematic biopsy has the shortcoming of sampling error and reveals "no evidence of @entity1 " with a rate of >50% on @entity3 ( @entity3 ). The objective of this study is to report our initial experience of applying a 3D-documented biopsy-mapping technology to precisely re-visit geographically documented @entity2 and to perform serial analysis of cell-cycle-progression (CCP) gene-panel. METHODS: Over a period of 40 months (1/2010-4/2013), the 3D-biopsy-mapping technique, in which the spatial location of biopsy-trajectory was digitally recorded (Koelis), was carried out. A pair of diagnostic (1st-look) and surveillance (2nd-look) biopsy were performed per subject (n   =   25), with median interval of 12 months. The documented biopsy-trajectory was used as a target to guide the re-visiting biopsy from the documented @entity1 focus, as well as the targeted field-biopsy from the un-sampled prostatic field adjacent to negative diagnostic biopsies. The accuracy of re-visiting biopsy and biopsy-derived CCP signatures were evaluated in the pair of the serial biopsy-cores. RESULTS: The 1st-look-biopsy revealed a total of 43 @entity1 (1.7 per @entity0 ). The accuracy of re-visiting @entity1 was 86% (37/43) per lesion, 76% (65/86) per core, and 80% (20/25) per @entity0 . This technology also provided an opportunity for 3D-targeted field-biopsy in order to potentially minimize sampling errors. The CCP gene-panel of the 1st-look (-0.59) versus 2nd-look (-0.37) samples had no significant difference (P   =   0.4); which suggested consistency in the molecular signature of the known @entity1 foci during the short-time interval of median 12 months. Any change in CCP of the same @entity1 foci would be likely due to change in sampling location from the less to more significant portion in the @entity1 foci rather than true molecular progression. The study limitations include a small number of the @entity0 . CONCLUSION: The 3D-documented biopsy-mapping technology achieved an encouraging re-sampling accuracy of 86% from the known @entity2 foci, allowing the serial analysis of biopsy-derived CCP signatures. Prostate    2015 Wiley Periodicals, Inc.

title: A novel technique using three-dimensionally documented biopsy mapping allows precise XXXX foci with serial surveillance of cell cycle progression gene panel.

answer: @entity2


abstract: BACKGROUND: The worldwide epidemic of @entity2 2 @entity1 (T2DM) underlines the need for @entity1 prevention strategies. In this study the feasibility and effectiveness of a nurse led lifestyle program for subjects with impaired fasting @entity3 (IFG) is assessed. METHODS: A cluster randomized clinical trial in 26 primary care practices in the Netherlands included 366 @entity0 older than 45  years with newly diagnosed IFG and motivated to change their lifestyle (intervention group, n   =   197; usual care group, n   =   169). The one-year intervention, consisting of four to five individual nurse-led consultations, was directed at improving physical activity and dietary habits. The primary outcome measure was body mass index (BMI). Linear and logistic multilevel analyses and a process evaluation were performed. RESULTS: Both groups showed small reductions in BMI at 1 and 2  years, but differences between groups were not significant. At both 1 and 2-year follow-up the number of @entity0 physically active for at least 30  minutes at least five days a week was significantly improved in the intervention group compared to the usual care group (intervention group vs. usual care group: OR1year   =   3.53; 95  % CI   =   1.69-7.37 and OR2years   =   1.97; 95  % CI   =   1.22-3.20, respectively). The total drop-out rate was 24  %. Process evaluation revealed that @entity0 in the intervention group received fewer consultations than advised, while some practice nurses and @entity0 considered the RM protocol too intensive. CONCLUSIONS: This relatively simple lifestyle program in subjects with IFG resulted in a significant improvement in reported physical activity, but not in BMI. Despite its simplicity, some @entity0 still considered the intervention too intensive. This viewpoint could be related to poor motivation and an absence of disease burden due to IFG, such that @entity0 do not feel a need for behavioural change. Although the intervention provided some benefit, its wider use cannot be advised. TRIAL REGISTRATION: Current Controlled Trials ISRCTN41209683 , date of registration 16/10/2013h   .

title: Effects of a lifestyle program in subjects with Impaired Fasting XXXX , a pragmatic cluster-randomized controlled trial.

answer: @entity3


abstract: UNASSIGNED: MicroRNAs (miRNA, @entity3 ) have been implicated as promising blood-based biomarkers for @entity1 @entity0 . This study aimed to clinically validate miRNA as potential @entity1 biomarkers. Plasma levels of 10 miRNAs were analyzed using qPCR in a cohort of 61 @entity1 @entity0 and 62 normal controls, as well as 25 @entity0 particularly selected for a six-week antipsychotic treatment course. Positive And Negative Syndrome Scale (PANSS), Global Assessment Scale (GAS) and Clinical Global Impression (CGI) were administered to assess the clinical symptoms. The results demonstrated that a panel of miRNAs consisting of @entity9 , @entity3 -181b, @entity2 , @entity8 and @entity4 had significantly increased expression levels with significant combined diagnostic value (AUC:0.713; sensitivity:35.5%; specificity:90.2%). In response to pharmacological treatment, expression levels of @entity5 , @entity3 -181b, @entity7 and @entity9 were significantly decreased. In addition, the improvement of clinical symptomatology was significantly correlated with the changes of @entity5 , @entity3 -181b, @entity6 and @entity9 expression levels. Furthermore, the decreases of plasma levels of @entity5 and @entity7 were significantly greater in high-effect subgroup than those in low-effect subgroup after six-week treatment course. We conclude that @entity9 , @entity3 -181b, @entity2 , @entity8 and @entity4 combined as a panel are potentially useful non-invasive biomarkers for @entity1 diagnosis. Markers @entity5 , @entity3 -181b, @entity9 and @entity7 are potential indicators for symptomatology improvements, treatment responses and prognosis for @entity1 @entity0 .    2015 Wiley Periodicals, Inc.

title: A preliminary analysis of microRNA as potential clinical biomarker for XXXX .

answer: @entity1


abstract: UNASSIGNED: Abstract Objectives: Around 40% of @entity1 @entity0 have lowered testosterone and symptoms of @entity4 but the prevalence of @entity4 among @entity3 @entity0 is unknown. The aim of this study was to investigate the prevalence of late-onset @entity4 (LOH) in population of Polish @entity0 with @entity3 . Methods: This study was performed in 196 @entity3 @entity0 and in 184 normoglycemic, control group. @entity3 was defined as impaired fasting @entity5 , @entity5 and/or HbA1c 5.7-6.4%. LOH was defined as low libido, diminished frequency of morning erections and @entity2 in @entity0 with total testosterone <12   nmol/l. Results: Total testosterone (TT) level in @entity3 group was 11.78        1.76 and 16.37        1.6   nmol/l in control group (p   <   0.001). LOH was diagnosed in 30% @entity3 @entity0 and in 13.6% control @entity0 . There were negative relationships between calculated free testosterone (cFT) and HbA1c (r   =   -0.3856; p   <   0.005). In @entity3 group, TT and cFT levels were lower in @entity0 with @entity5 than impaired fasting @entity5 (p   <   0.05 and p   <   0.02, respectively). We showed inverse relationships between IIEF-5 score and cFT (r   =   -0.414, p   <   0.005) and between IIEF-5 and HbA1c (r   =   -0.395, p   <   0.002). Conclusions: In population of Polish @entity0 with @entity3 we observed high prevalence of LOH. Routine testosterone screening should be performed in all @entity3 @entity0 .

title: Late-onset XXXX among old and middle-aged males with @entity3 in Polish population.

answer: @entity4


abstract: UNASSIGNED: Abstract Objectives: Around 40% of @entity1 @entity0 have lowered testosterone and symptoms of @entity4 but the prevalence of @entity4 among @entity3 @entity0 is unknown. The aim of this study was to investigate the prevalence of late-onset @entity4 (LOH) in population of Polish @entity0 with @entity3 . Methods: This study was performed in 196 @entity3 @entity0 and in 184 normoglycemic, control group. @entity3 was defined as impaired fasting @entity5 , @entity5 and/or HbA1c 5.7-6.4%. LOH was defined as low libido, diminished frequency of morning erections and @entity2 in @entity0 with total testosterone <12   nmol/l. Results: Total testosterone (TT) level in @entity3 group was 11.78        1.76 and 16.37        1.6   nmol/l in control group (p   <   0.001). LOH was diagnosed in 30% @entity3 @entity0 and in 13.6% control @entity0 . There were negative relationships between calculated free testosterone (cFT) and HbA1c (r   =   -0.3856; p   <   0.005). In @entity3 group, TT and cFT levels were lower in @entity0 with @entity5 than impaired fasting @entity5 (p   <   0.05 and p   <   0.02, respectively). We showed inverse relationships between IIEF-5 score and cFT (r   =   -0.414, p   <   0.005) and between IIEF-5 and HbA1c (r   =   -0.395, p   <   0.002). Conclusions: In population of Polish @entity0 with @entity3 we observed high prevalence of LOH. Routine testosterone screening should be performed in all @entity3 @entity0 .

title: Late-onset @entity4 among old and middle-aged males with XXXX in Polish population.

answer: @entity3


abstract: Evoked potentials (EPs) of the dorsal hippocampus were recorded in non-immobilized non-anaesthetized @entity0 before and after tetanization of the medial septum and the dentate fascia. Changes of @entity2 ( @entity3 ) efficiency were tested during long-lasting potentiation (LLP) and @entity1 ( @entity1 ). Increase in the amplitude of the EP fast component (population spike) during microiontophoresis of @entity3 was used as an index of @entity3 efficiency. In various tests both decrease and enhancement of @entity3 efficiency after tetanization were observed independent of the LLP or @entity1 appearance. "Relative" @entity3 efficiency in most cases decreased during LLP and enhanced during @entity1 . These changes were nonspecific since they were observed in response to the stimulation of both medial septum (cholinergic input), and dentate fascia (non-cholinergic input). Reactions to the stimulation of the control (non-tetanized) input were mainly depressed with diminution of @entity3 efficiency. The above experiments do not confirm the hypothesis that LLP and @entity1 are based on respective changes in the sensitivity of the subsynaptic membrane to the transmitter. The most probable LLP mechanism seems to be the enhancement of synaptic efficiency due to increased release of the transmitter. @entity1 mechanisms probably include changes at the level of the postsynaptic membrane and call for further analysis.

title: [Effect of @entity2 on hippocampal response during long-term post-tetanic potentiation and XXXX of the medial septum and dentate gyrus].

answer: @entity1


abstract: Evoked potentials (EPs) of the dorsal hippocampus were recorded in non-immobilized non-anaesthetized @entity0 before and after tetanization of the medial septum and the dentate fascia. Changes of @entity2 ( @entity3 ) efficiency were tested during long-lasting potentiation (LLP) and @entity1 ( @entity1 ). Increase in the amplitude of the EP fast component (population spike) during microiontophoresis of @entity3 was used as an index of @entity3 efficiency. In various tests both decrease and enhancement of @entity3 efficiency after tetanization were observed independent of the LLP or @entity1 appearance. "Relative" @entity3 efficiency in most cases decreased during LLP and enhanced during @entity1 . These changes were nonspecific since they were observed in response to the stimulation of both medial septum (cholinergic input), and dentate fascia (non-cholinergic input). Reactions to the stimulation of the control (non-tetanized) input were mainly depressed with diminution of @entity3 efficiency. The above experiments do not confirm the hypothesis that LLP and @entity1 are based on respective changes in the sensitivity of the subsynaptic membrane to the transmitter. The most probable LLP mechanism seems to be the enhancement of synaptic efficiency due to increased release of the transmitter. @entity1 mechanisms probably include changes at the level of the postsynaptic membrane and call for further analysis.

title: [Effect of XXXX on hippocampal response during long-term post-tetanic potentiation and @entity1 of the medial septum and dentate gyrus].

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Computed tomographic (CT) @entity4 ( @entity4 ) areas after endovascular therapy for acute @entity3 are a common finding indicative of blood-brain barrier disruption. @entity7 allows an accurate differentiation between @entity4 areas related to @entity1 ( @entity1 ) or to @entity6 ( @entity6 ). We sought to evaluate the prognostic significance of the presence of @entity1 and @entity6 after endovascular therapy. METHODS: A prospective cohort of 132 @entity0 treated with endovascular therapy was analyzed. According to dual-energy CT findings, @entity0 were classified into 3 groups: no @entity4 areas (n=53), @entity1 (n=32), and @entity6 (n=47). The rate of new @entity5 transformations was recorded at follow-up neuroimaging. Clinical outcome was evaluated at 90 days with the modified Rankin Scale (poor outcome, 3-6). RESULTS: Poor outcome was associated with the presence of @entity1 (odds ratio [OR], 11.3; 95% confidence interval, 3.34-38.95) and @entity6 (OR, 10.4; 95% confidence interval, 3.42-31.68). The rate of poor outcome despite complete recanalization was also significantly higher in @entity1 (OR, 9.7; 95% confidence interval, 2.55-37.18) and @entity6 (OR, 15.1; 95% confidence interval, 3.85-59.35) groups, compared with the no- @entity4 group. @entity0 with @entity1 disclosed a higher incidence of delayed @entity5 transformation at follow-up (OR, 4.5; 95% confidence interval, 1.22-16.37) compared with no- @entity4 @entity0 . CONCLUSIONS: Blood-brain barrier disruption, defined as @entity1 and @entity6 on dual-energy CT, was associated with poor clinical outcomes in @entity0 with @entity2 treated with endovascular therapies. Moreover, isolated @entity1 was associated with delayed @entity5 transformation. These results support the clinical relevance of blood-brain barrier disruption in @entity2 .

title: Relevance of Blood-Brain Barrier Disruption After Endovascular Treatment of XXXX : Dual-Energy Computed Tomographic Study.

answer: @entity3


abstract: OBJECTIVE: Platelets contribute to @entity7 , and platelet @entity11 ( @entity11 ) are central in pathogen detection, potentially mediating infection-induced @entity5 . Using a large community-based cohort study, we sought to examine if platelets express all known TLR transcripts and analyze their association with cardiovascular risk factors. APPROACH AND RESULTS: mRNA levels for @entity11 were measured in isolated platelets by high-throughput quantitative reverse transcriptase polymerase chain reaction in 1625 @entity0 (mean age, 66.6  9; 54% @entity0 ) of the Framingham Heart Study. We measured circulating inflammatory and thrombotic markers ( @entity8 , @entity6 , @entity9 , intracellular cell adhesion molecule 1, soluble @entity1 @entity2 factor-a receptor 1, and soluble @entity14 ) and analyzed @entity11 and their association with sex and cardiovascular risk factors by multivariable logit regression model adjusted for confounding factors. Platelets expressed all 10 TLR transcripts, and all @entity11 were coexpressed. @entity0 had higher platelet TLR expression, which associated with different cardiovascular risk factors, compared with @entity0 . In @entity0 , @entity15 , @entity13 , @entity16 , and @entity12 were associated with body mass index and @entity17 , @entity12 , and @entity19 were associated with total @entity4 to high-density lipoprotein ratio. In @entity0 , @entity15 , @entity10 , and @entity13 were associated with lipid and @entity18 with @entity3 treatment. Similarly, TLR expression in @entity0 was more commonly associated with circulating inflammatory markers (soluble @entity1 @entity2 factor-a receptor 1 and intracellular cell adhesion molecule 1), whereas in @entity0 , TLR expression was associated with soluble @entity14 levels. CONCLUSIONS: We report the first study to demonstrate that platelets express all TLR transcripts using a large community-based observational cohort. These transcripts are more abundant in @entity0 and have distinct associations with cardiovascular risk and inflammatory biomarkers that vary by sex.

title: Sex differences in platelet XXXX and their association with cardiovascular risk factors.

answer: @entity11


abstract: 61 @entity0 with constitutional delay of growth and maturation, aged 9-19 years and with a bone age (BA) lag of 1.3-5.5 years, were administered @entity1 (0.05-0.24 mg/kg daily orally, relative dose increasing with age) to accelerate growth. The therapy was continuous and lasted 0.4-3.6 years. The findings are compared with 37 observation periods in a similar group of untreated @entity0 . Growth velocity increased in every treated @entity0 during the therapy, the mean first-year increment being 4.3 +/- 1.6 cm/year. For most @entity0 this brought about a decrease in the height difference from peers, and so afforded the psychosocial relief that was the objective of the therapy. After therapy the velocity decreased slightly in most @entity0 , from a mean of 9.1 +/- 1.4 to 7.1 +/- 3.3 cm/year. The effect of the intervention on final height was assessed by three relatively independent methods of prediction. These were found to be equally valid in the 15 control @entity0 for whom final heights are known. The effect appeared to vary individually, but on the average there appeared to be no loss of height potential. No individual @entity0 with initial BA greater than 10.5 years showed a substantial reduction in predicted final height.

title: Acceleration of delayed growth with XXXX .

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity6 ) is caused by @entity4 ). India is considered as a nonendemic region for @entity4 . Recent upsurge of cases have been noted in southern parts of India. AIMS AND OBJECTIVES: The objective was to describe skin manifestations in various types of @entity6 . MATERIALS AND METHODS: Clinical examination, blood investigations, skin biopsies, lymph node biopsies, and immunohistochemistry were performed in five @entity0 . Flow cytometry was performed in two cases. RESULTS: Serological testing was positive for @entity4 in all @entity0 . All @entity0 presented with @entity1 . Rare presentations of molluscum contagiosum like papules, purpuric macules and plaques, hypopigmented macules and verrucous papules were seen. @entity2 occurred in two @entity0 . @entity5 was seen in one @entity0 . Histological features include @entity3 with or without epidermotropism. Presence of epidermotropism did not correlate with the severity of disease. All @entity0 except one succumbed to illness within few months to 1 year period. CONCLUSIONS: @entity6 manifest in myriad presentations and @entity1 are often the earliest manifestation. Cutaneous manifestations of @entity6 vary from subtle hypopigmented macules to florid nodular lesions, and @entity4 screening need to be carried out in all doubtful cases.

title: Multifaceted XXXX in India: a case series.

answer: @entity6


abstract: Ms. V, a 10-year-old @entity0 was referred to @entity0 Psychiatry Department with complaints of @entity2 from eyes for last 3 months. Bleeding was spontaneous, recurrent, painless, and self-limited. History revealed significant Psychological stressors, Temperamental Difficulties and Conflicts with Mother. Mental status examination revealed @entity1 in Ms. V. During hospital stay, Ms. V developed repeated @entity2 episodes. The presence of hemoglobin is confirmed in the @entity2 sample. Hematologic investigations and computed tomography brain were normal. Ms. V was started on @entity5 , @entity3 , and @entity4 . Both Ms. V and her Mother were psycho-educated about the nature of the illness. Ms. V was discharged and under follow-up. This case is reported for the rarity of presentation ( @entity2 from Eyes) of a childhood @entity1 .

title: The story of a @entity0 with weeping blood: XXXX with a rare presentation.

answer: @entity1


abstract: Ms. V, a 10-year-old @entity0 was referred to @entity0 Psychiatry Department with complaints of @entity2 from eyes for last 3 months. Bleeding was spontaneous, recurrent, painless, and self-limited. History revealed significant Psychological stressors, Temperamental Difficulties and Conflicts with Mother. Mental status examination revealed @entity1 in Ms. V. During hospital stay, Ms. V developed repeated @entity2 episodes. The presence of hemoglobin is confirmed in the @entity2 sample. Hematologic investigations and computed tomography brain were normal. Ms. V was started on @entity5 , @entity3 , and @entity4 . Both Ms. V and her Mother were psycho-educated about the nature of the illness. Ms. V was discharged and under follow-up. This case is reported for the rarity of presentation ( @entity2 from Eyes) of a childhood @entity1 .

title: The story of a XXXX with weeping blood: @entity1 with a rare presentation.

answer: @entity0


abstract: OBJECTIVE: To discuss surgical approach selection and treatment strategy for preservation of the facial and lower cranial nerves' function in jugular foramen @entity5 surgery. METHODS: Retrospectively analyzed the clinical presentation, surgical approaches selection, facial and lower cranial nerves follow-up outcomes of 38 jugular foramen @entity5 , who received operations in the Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital affiliated to Shanghai Jiaotong University, School of Medicine during 2002 and 2012. RESULTS: A total of 38 @entity0 , including 18 @entity0 and 20 @entity0 , with ages ranged from 21 to 70 years (mean 45.3). @entity2 or @entity8 in preoperative clinical presentation was present in 27 @entity0 (71.1%) and cervical mass in 9 @entity0 (23.7%). @entity4 , mainly the vagus nerve, were present in 21 @entity0 (55.3%). MRI finding: 19 @entity1 were intra- and extracranial, 10 were intracranial and 9 were extracranial. According to the @entity1 location and region, select the surgical approaches. 25 @entity0 used infratemporal fossa type A approach, 5 @entity0 used petrous occipital transsigmoid approach and 8 @entity0 used transcervial approach to remove @entity1 . The percentage of total resection was 92.1% (35/38). Adjunctive radiosurgery was used in the management of @entity3 in two @entity0 . All cases obtained ultimately @entity1 control. @entity0 were followed by MRI every 6 months for 1 year. Thereafter, they performed follow-up imaging every 1-2 years, and the @entity4 was analyzed and evaluated. They were followed up from 26-124 months (median follow-up was 62.3 months). During follow-up period, good facial function was obtained in 36 @entity0 (94.7%). All @entity0 had no @entity6 . Complete compensation of lower @entity4 was achieved in all @entity0 . CONCLUSIONS: The preoperative estimation and location of @entity1 in nature is of great importance in the determination of proper surgical planning of jugular foramen @entity5 . @entity7 and lower @entity4 can be preserved in maximal degree by proper surgical approaches and careful operative manipulation. Initial surgical resection followed by radiosurgery may be an effective option for some special @entity0 .

title: [Management of jugular foramen XXXX ].

answer: @entity5


abstract: BACKGROUND: Primary extended resection has been proposed as the initial treatment for @entity0 with @entity3 . This approach comprises an extended en-bloc resection of the directly infiltrated organs and adjacent uninvolved organs. The results of such radical surgery have yet to be validated. This retrospective study aims to investigate this practice in a contemporary series from a referral center in the UK. METHODS: We extracted data from consecutive @entity0 who underwent extended resectional surgery between 2009 and 2013, and investigated the type of resection performed, the effectiveness of extended surgery in providing negative microscopic margins, and the occurrence of post-surgical adverse events. RESULTS: A total of 69 @entity0 were included. Fifty-two @entity0 had a primary @entity1 (75.4  %), and in 55 @entity0 (79.7  %) the @entity1 was resected en bloc with adjacent organs or structures. Colonic resection (N  =  35, 50.7  %) and nephrectomy (N  =  28, 40.6  %) were the most frequently performed organ resections. Organs were infiltrated in 22 @entity0 (32  %), and there was no association between organ infiltration and @entity0 variables and staging characteristics. Negative microscopic margins were achieved in 88.6  % of @entity0 in this series. @entity4 occurred in 21 @entity0 (30  %) and a reoperation was required in ten cases (14.5  %). No independent predictors of morbidity were identified and no 30-day postoperative @entity2 occurred. CONCLUSIONS: Four-fifths of @entity0 in this series had organs removed in association with the @entity3 . This approach in a specialist sarcoma unit results in negative microscopic @entity1 margins in up to 90  % of cases and can be performed safely.

title: Outcomes Following Extended Surgery for XXXX : Results From a UK Referral Centre.

answer: @entity3


abstract: BACKGROUND: Prenatal @entity2 disrupts the pattern of maturation and development of the hippocampus and its neuroanatomy and increases inhibition of the granular cell layer of the fascia dentata. If local @entity1 inter-neurons are partly responsible for inhibition of the hippocampus, it is reasonable to assume that there may be an increase in the @entity1 cell population of prenatal @entity2 @entity0 . OBJECTIVE: This experimental study was conducted to ascertain the effects of prenatal @entity2 on the density of GABAergic interneurons at the cornus ammonis and fascia dentata in @entity0 . METHODS: Animals were investigated under two nutritional conditions: (i) prenatal @entity2 group fed 6% protein, and (ii) well-nourished control group fed 25% protein. Using an antibody for @entity1 , immunoreactive cells (GABAergic) were assessed in the rostral-caudal direction of the dorsal hippocampus at four levels. RESULTS: (i) In 30-day-old @entity0 with prenatal @entity2 , the fascia dentata had an average of 27% more GABAergic cells than the control group; this higher amount was not detectable at 90 days. (ii) There was a significant 18% increase in GABAergic neurons at level 1 of the cornus ammonis at 90 days of age. CONCLUSIONS: There was an increase in the population of interneurons in the fascia dentata and cornus ammonis in prenatal @entity2 @entity0 . We conclude that prenatal hypoprotein @entity2 produces changes at 30 days in the fascia dentata. Results suggest that prenatal @entity2 also produces a delay in the programmed chronology of @entity1 interneurons. Finally, in cornus ammonis, at 90 days of age, prenatal @entity2 showed an increase only at level 1; this effect may be evidenced in the long term, despite postnatal rehabilitation.

title: Prenatal Protein Malnutrition Affects the Density of GABAergic Interneurons During Hippocampus Development in XXXX .

answer: @entity0


abstract: Over the past decades, @entity4 (serum @entity3 <0.7 mmol/L) has been strongly associated with @entity1 ( @entity1 ). @entity0 with @entity4 show a more rapid disease progression and have an increased risk for @entity5 . Clinical studies demonstrate that @entity1 @entity0 with @entity4 have reduced pancreatic b-cell activity and are more @entity6 resistant. Moreover, dietary @entity3 supplementation for @entity0 with @entity1 improves glucose metabolism and @entity6 sensitivity. Intracellular @entity3 regulates glucokinase, KATP channels, and L-type @entity2 channels in pancreatic b-cells, preceding @entity6 secretion. Moreover, @entity7 autophosphorylation is dependent on intracellular @entity3 concentrations, making @entity3 a direct factor in the development of @entity6 resistance. Conversely, @entity6 is an important regulator of @entity3 homeostasis. In the kidney, @entity6 activates the renal @entity3 channel transient receptor potential melastatin type 6 that determines the final urinary @entity3 excretion. Consequently, @entity0 with @entity1 and @entity4 enter a vicious circle in which @entity4 causes @entity6 resistance and @entity6 resistance reduces serum @entity3 concentrations. This Perspective provides a systematic overview of the molecular mechanisms underlying the effects of @entity3 on @entity6 secretion and @entity6 signaling. In addition to providing a review of current knowledge, we provide novel directions for future research and identify previously neglected contributors to @entity4 in @entity1 .

title: XXXX in Type 2 Diabetes: A Vicious Circle?

answer: @entity4


abstract: UNASSIGNED: Studies comparing rabbit antithymocyte globulin (rATG) and @entity2 ATG (hATG) in @entity0 with @entity3 ( @entity3 ) have shown conflicting results. These studies included fewer than 60 subjects in the rATG arm with relatively short follow-up. A total of 169 @entity0 treated with rATG and 62 treated with hATG were included in this retrospective analysis, across 33 centers. @entity0 were treated with rATG or hATG plus cyclosporine A. Over half were classified, as having severe @entity3 (SAA) or very severe @entity3 (VSAA), and the mean follow-up was 45  months. There was no significant difference detected in cumulative response to treatment or survival between the rATG and hATG groups. The response to treatment was 63  % in the rATG group versus 66  % in the hATG group at 3  months. By 12  months, this pattern had reversed, and 84  % of rATG @entity0 had responded to treatment versus 76  % in the hATG group (n.s.). Early mortality due to @entity1 tended to be higher with rATG compared to hATG (n.s). rATG and hATG would seem to be therapeutically equivalent in SAA and VSAA. However, @entity0 treated with rATG may take longer to respond than those treated with hATG and may also require more active prevention of @entity1 .

title: Rabbit antithymocyte globulin versus horse antithymocyte globulin for treatment of acquired XXXX : a retrospective analysis.

answer: @entity3


abstract: @entity0 proprioception is essential for motor control, yet its central processing is still debated. Previous studies of passive movements and illusory vibration have reported inconsistent activation patterns related to proprioception, particularly in high-order sensorimotor cortices. We investigated brain activation specific to proprioception, its laterality, and changes following @entity1 . Twelve healthy and three @entity1 -affected individuals with @entity2 participated. Proprioception was assessed clinically with the Wrist Position Sense Test, and @entity0 underwent functional magnetic resonance imaging scanning. An event-related study design was used, where each proprioceptive stimulus of passive wrist movement was followed by a motor response of mirror -copying with the other wrist. Left (LWP) and right (RWP) wrist proprioception were tested separately. Laterality indices (LIs) were calculated for the main cortical regions activated during proprioception. We found proprioception-related brain activation in high-order sensorimotor cortices in healthy @entity0 especially in the supramarginal gyrus (SMG LWP z   =   4.51, RWP z   =   4.24) and the dorsal premotor cortex (PMd LWP z   =   4.10, RWP z   =   3.93). Right hemispheric dominance was observed in the SMG (LI LWP mean 0.41, SD 0.22; RWP 0.29, SD 0.20), and to a lesser degree in the PMd (LI LWP 0.34, SD 0.17; RWP 0.13, SD 0.25). In @entity1 -affected @entity0 , the main difference in proprioception-related brain activation was reduced laterality in the right SMG. Our findings indicate that the SMG and PMd play a key role in proprioception probably due to their role in spatial processing and motor control, respectively. The findings from @entity1 --affected individuals suggest that decreased right SMG function may be associated with decreased proprioception. We recommend that clinicians pay particular attention to the assessment and rehabilitation of proprioception following right hemispheric lesions.

title: The Right Supramarginal Gyrus Is Important for Proprioception in Healthy and Stroke-Affected XXXX : A Functional MRI Study.

answer: @entity0


abstract: INTRODUCTION: Lumbar degenerative spondylolisthesis is a major cause of impaired quality of life and diminished functional capacity in the elderly. @entity1 often involves only one or two level and tend to present with one or two level @entity2 . CASE REPORT: The authors describe an unusual case of degenerative spondylolisthesis involving 3 levels of the lumbar spine from L2 to L5. The @entity0 was a 58-year-old @entity0 who suffered @entity4 and @entity3 . Plain radiography revealed grade I degenerative spondylolisthesis at L2-L3, L3-L4 and L4-L5. Elevated pedicle-facet joint angles and W-type facet joints at the lumbar spine was observed. Magnetic resonance imaging showed L2-S1 @entity5 at the lumbar spine. @entity0 underwent L2-S1 decompression laminectomy and posterior lateral fusion of L2-S1 with posterior instrumentation and bone grafting. Symptoms improved significantly at 4 months follow-up. CONCLUSION: Thorough evaluation for multilevel segmental involvement in degenerative spondylolisthesis is important because of the frequency of severe symptomatic @entity2 or foraminal encroachment. Good surgical outcome can be expected from decompression and stabilisation. The pathogenesis of multi-level lumbar degenerative spondylolisthesis can be complex and heterogeneous.

title: A case report of 3-level degenerative spondylolisthesis with XXXX .

answer: @entity2


abstract: BACKGROUND _ PURPOSE: Globally, @entity1 is one of the most common non-contagious diseases resulting in severe complications. Fostered hope facilitates coping and improves self-care and one of the Factors affecting hope is religious beliefs. This research investigated the level of hope and its relationship with religious coping among @entity2 2 @entity1 @entity0 . MATERIAL _ METHODS: This correlation, cross-sectional study was conducted on 150 @entity0 with @entity2 2 @entity1 , who had been referred to the Karaj @entity1 Association during the period, March-June 2011, and selected through purposive sampling. A three-part questionnaire including demographic data, the Herth Hope Index, and a short form of religious coping, was used for data collection. The data were analyzed using descriptive and analytic statistics, including Pearson's correlation coefficient, the t-test, a one-way ANOVA, and a multiple regression analysis. The set significance level was p<0.05. RESULTS: The mean hope score was 34.89 (SD  8.75); most of the subjects (46.7%) showed high levels of hope. Positive religious coping, marital status, and social support significantly affected hope fostering(r=0.897, p =0.000). A significant negative relationship was found between hope and age (r=-0.373, p=0.000), and between hope and negative religious coping (r=-0.749, p=0.000). CONCLUSION: Positive religious coping, married life, and social support significantly affected the development of hope. Moreover, there was a significant positive relationship between positive religious coping and social support. So, strengthening social support could lead to increased levels of positive religious coping and fostering of hope.

title: The Relationship Between Hope and Religious Coping Among XXXX With Type 2 Diabetes.

answer: @entity0


abstract: AIM: @entity1 is a life-threatening condition. Considerable doubts exist over the effects of this disease on @entity0 ' sexual activity and satisfaction. The aim of this study was to evaluate the relationship between @entity1 and sexual satisfaction. METHODS: In a retrospective cohort study, the convenience sample of 150 @entity0 exposure with @entity1 and 150 @entity0 without exposure it was drawn from Shahid Beheshti hospital, Kashan, Iran. Sampling was performed from March to September 2014. We employed the Larson's Sexual Satisfaction Questionnaire for gathering the data. Data were analyzed using descriptive statistics and Chi-square, t-test and linear regression analysis. RESULTS: The means of sexual satisfaction in @entity0 exposure with @entity1 and among the subjects without exposure it were 101.47  13.42 and 100.91  16.52, respectively. There was no significant difference between the two groups regarding sexual satisfaction. However, sexual satisfaction was significantly correlated with gender and the use of cardiac medications (P value<0.05). CONCLUSION: The level of sexual satisfaction in @entity0 with exposure @entity1 is similar to the @entity0 without exposure it. Moreover, the @entity0 and the @entity0 who do not receive cardiac medications have higher levels of sexual satisfaction. Nurses who are providing care to @entity0 with @entity1 need to pay closer attention to @entity0 education about sexual issues.

title: Relationship Between XXXX and Sexual Satisfaction.

answer: @entity1


abstract: OBJECT Ependymomas of the filum terminale provide specific surgical challenges due to their often enormous size, contact with nerve roots of the cauda equina and conus, and potential for @entity4 . This study presents treatment results for these @entity1 over a 30-year period. METHODS Among 1447 @entity0 with @entity1 of the spinal canal treated between 1980 and 2014, 618 @entity0 presented with extramedullary @entity1 . Of these, 42 @entity0 (25 males, 17 females) demonstrated a @entity3 in the lumbosacral region. Thirty-four @entity0 underwent 36 operations for 39 such @entity1 . The mean @entity0 age was 38    14 years (range 11-73 years), with an average clinical history of 37    67 months. @entity0 were followed through outpatient visits and questionnaires, with a mean follow-up of 10 years (127    100 months). Twenty-seven operations were performed to treat de novo @entity1 and the remainder were undertaken on recurrent @entity1 . Short-term results were determined for individual symptoms, and @entity1 recurrence rates were calculated with Kaplan-Meier statistical analyses. RESULTS Subarachnoid dissemination was observed in 11 @entity0 and was related to previous surgery in 9 @entity0 and associated with extensive @entity1 in 2 @entity0 . Gross-total resections (GTR) were achieved in 28 operations (77.7%) and subtotal resections in the remainder. Subtotal resections were restricted to @entity3 (61.5%). Radiotherapy was employed after 6 operations on unencapsulated @entity1 , with 5 of these also demonstrating subarachnoid seeding. Permanent surgical morbidity affected 3 @entity0 who experienced permanent @entity5 , while 7 @entity0 showed no postoperative changes, and the remaining 26 operations were followed by improvements. Long-term outcome depended on the amount of resection and the presence of a @entity1 capsule. Eight of 9 @entity1 recurrences affected unencapsulated @entity1 , of which 3 had undergone GTR. The overall recurrence rates were 6.6%, 19.0%, and 37.0% after 1, 10, and 20 years, respectively. For @entity3 , the corresponding rates were 15.6%, 32.5%, and 66.2% after 1, 10, and 20 years, respectively, with significantly lower rates of 9.1% after 10 and 20 years for encapsulated @entity1 . Postoperative radiotherapy tended to prolong the recurrence-free interval for @entity0 with unencapsulated @entity1 . Five @entity0 @entity2 occurred during follow-up, of which 2 @entity2 were @entity1 related and occurred at 216 and 287 months after surgery. CONCLUSION @entity3 are @entity1 in the lumbosacral region, sometimes with an indolent course for long periods of time. Despite their delicate location and often enormous size, surgical morbidity in experienced hands is low, with good chances for postoperative clinical improvements and very low recurrence rates after GTR for encapsulated @entity1 . The role of postoperative radiotherapy remains controversial. Radiotherapy may be considered after incomplete resections of unencapsulated @entity1 and/or for @entity0 with @entity4 .

title: XXXX . Part 2: Ependymomas of the filum terminale.

answer: @entity3


abstract: UNASSIGNED: Invasive coronary angiography (ICA) was the only method to image coronary arteries for a long time and is still the gold-standard. Technology of noninvasive imaging by coronary computed-tomography angiography (CCTA) has experienced remarkable progress during the last two decades. It is possible to visualize @entity3 in the vessel wall in contrast to "lumenography" performed by ICA. @entity1 can be ruled out by CCTA with excellent accuracy. The degree of stenoses is, however, often overestimated which impairs specificity. @entity3 can be characterized as calcified, non-calcified and partially calcified. Calcified plaques are usually quantified using the Agatston-Score. Higher scores are correlated with worse cardiovascular outcome and increased risk of @entity0 . For non-calcified or partially calcified plaques different angiographic findings like positive remodelling, a large necrotic core or spotty calcification more frequently lead to @entity2 . CCTA is an important tool with increasing clinical value for ruling out @entity1 or relevant stenoses as well as for advanced risk stratification.

title: Coronary CT Angiography in Managing XXXX .

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity3 ) is the most common of the ocular @entity1 .This study evaluates the types of @entity3 and its management in @entity0 presenting to the paediatric and strabismus unit of a tertiary care eye hospital. METHODS: This case series study involved 41 @entity0 diagnosed with @entity3 between January 2007 and December 2009. History of presenting complaints, past treatment and family history were recorded. Ocular examination and orthoptic assessment was carried out RESULTS: Forty one @entity0 were included in this case series study. It involved 10 right eyes, 27 @entity2 @entity0 . There were 26 females and 15 males. @entity3 was present in 28 (68.3%), type 2 in 8 (19.5%), Type-3 in 4 (9.8%) and type-4 with synergistic divergence was present in 1 (2.4%) @entity0 . Comorbidity was present in 6(14.6%) @entity0 . Surgery was carried out in 26 (63.4%) @entity0 either for   abnormal head posturing or significant upshoots or down shoots. Upshoots noted in 21 eyes, were completely or partially resolved in 15 cases. Among 4 @entity0 with down shoots on adduction, complete resolution was seen in 1. The pre and post-operative measurements of horizontal deviation showed statistically significant difference in Duane type-1 and 2, where as in Duane type-3 it was not significant. One @entity0 with type-4 Duane did not undergo surgery. CONCLUSIONS: Recession of the horizontal recti is more effective in treating the upshoot or down shoot associated with @entity3 as compared to recession and y-split of the horizontal muscle.

title: XXXX : surgical outcome and non ophthalmologic associations.

answer: @entity3


abstract: BACKGROUND: There are no conclusive cost-effectiveness studies measuring the efficacy of salvage LT after liver resection (LR) and radiofrequency ablation (RFA) in @entity0 with @entity3 ( @entity3 ) and compensated @entity2 . The aim of the present study is to compare liver transplantation (LT) versus locoregional therapy plus salvage LT (to treat @entity1 recurrence) in @entity0 with early @entity3 and compensated @entity2 . METHODS: Reference case: 55-year old male with @entity3 within Milan criteria and @entity0 -Pugh A @entity2 . The analysis was performed in two geographical cost settings: USA and Italy. Survival benefit measured in quality-adjusted life years (QALYs), costs (C) in US , incremental cost-effectiveness, willingness to pay, and net health benefit (NHB). RESULTS: In the base-case analysis, NHB of LT vs. LR and RFA was -1.7 and -1.3  years for @entity1   <=3  cm, -1.2 and -0.7 for single nodules measuring 3.1-5  cm and -0.7 and -0.7 for @entity1   <=3  cm in Italy. In USA, NHB of LT versus LR and RFA were -1.2 and -0.8  years for @entity1   <=3  cm, -0.9 and -0.5 for single nodules measuring 3.1-5  cm, and -0.5 and -0.4 for @entity1   <=  3  cm. On the Monte Carlo simulation, only young @entity0 with multi-nodular @entity3 and short waiting list time had a positive NHB. Salvage LT proved to be an ineffective cost strategy after RFA or LR. CONCLUSION: In @entity0 with @entity3 within Milan criteria and @entity0 -Pugh A @entity2 , LR and RFA were more cost-effective than LT. Salvage LT was not cost-effective.

title: The Relative Net Health Benefit of Liver Resection, Ablation, and Transplantation for Early XXXX .

answer: @entity3


abstract: To determine the LH release response to @entity5 in @entity0 with virilizing @entity4 ( @entity4 ), we examined six @entity0 with glucocorticoid-treated virilizing @entity4 , five @entity0 and one @entity0 , chonological age (CA) 4 years 2 months-15 years 9 months and bone age (BA) range 8-18 years. All the @entity0 but one, were treated with nocturnal @entity2 . Their ages at the onset of treatment ranged from 2 years 6 months to 13 years 8 months. An additional @entity0 (CA = 4 years 3 months and BA = 7-8 years) was studied 10 days after removal of a virilizing @entity3 . @entity5 (3mg/kg/day) was administered orally in two doses/day for 8 days. Venous blood was collected on days 0, 4, 6 and 8. Two @entity0 were also studied in consecutive years. In three @entity0 no increase was noted over the basal levels of LH, but in the others LH rose during @entity5 administration. In two @entity0 studied in consecutive years, there was detectable shift of LH release pattern. The basal LH levels and the sum of responses (day 4, 6 and 8) to @entity5 and particularly their decimal logarithms were statistically significantly correlated with their respective BA. These results confirm that previous prolonged exposure to elevated concentrations of adrenal sex @entity1 , in @entity0 with treated virilizing @entity4 , may induce precocious maturation of the hypothalamic pubertal mechanism of LH secretion. This maturation was closely correlated with the degree of skeletal maturation.

title: Pubertal maturation of the lh stimulatory response to XXXX in congenital virilizing @entity4 .

answer: @entity5


abstract: To determine the LH release response to @entity5 in @entity0 with virilizing @entity4 ( @entity4 ), we examined six @entity0 with glucocorticoid-treated virilizing @entity4 , five @entity0 and one @entity0 , chonological age (CA) 4 years 2 months-15 years 9 months and bone age (BA) range 8-18 years. All the @entity0 but one, were treated with nocturnal @entity2 . Their ages at the onset of treatment ranged from 2 years 6 months to 13 years 8 months. An additional @entity0 (CA = 4 years 3 months and BA = 7-8 years) was studied 10 days after removal of a virilizing @entity3 . @entity5 (3mg/kg/day) was administered orally in two doses/day for 8 days. Venous blood was collected on days 0, 4, 6 and 8. Two @entity0 were also studied in consecutive years. In three @entity0 no increase was noted over the basal levels of LH, but in the others LH rose during @entity5 administration. In two @entity0 studied in consecutive years, there was detectable shift of LH release pattern. The basal LH levels and the sum of responses (day 4, 6 and 8) to @entity5 and particularly their decimal logarithms were statistically significantly correlated with their respective BA. These results confirm that previous prolonged exposure to elevated concentrations of adrenal sex @entity1 , in @entity0 with treated virilizing @entity4 , may induce precocious maturation of the hypothalamic pubertal mechanism of LH secretion. This maturation was closely correlated with the degree of skeletal maturation.

title: Pubertal maturation of the lh stimulatory response to @entity5 in congenital virilizing XXXX .

answer: @entity4


abstract: BACKGROUND: Although of interest, few data exist on the clinical characteristics of Japanese @entity1 with an extremely high @entity6 level (>= 1000  mg/dL). OBJECTIVE: We assessed the clinical characteristics of Japanese @entity1 with an extremely high @entity6 level. METHODS: We investigated the presence of @entity7 , history of @entity8 , the presence of @entity11 , and the potential causes of elevated @entity6 in Japanese subjects with an extremely high level of fasting @entity6 (>= 1000  mg/dL) among 70,368 subjects whose serum @entity6 was measured for any reason at Kanazawa University Hospital from April 2004 to March  2014. RESULTS: We identified 215 (0.31%) subjects (mean age, 46  years; male, 170, mean body mass index, 25  kg/m(2)) with severe @entity12 . Among them, 4 (1.9%) subjects were classified as type I, 97 (45.1%) subjects were type IV, and 114 (53.0%) subjects were @entity15 , according to Fredrickson's classification. Among 215 subjects, 116 subjects (54.0%) drank @entity4 , 58 (27.0%) showed heavy intake (>= 60  g/d), and 64 (29.8%) subjects had @entity2 . In total, 59 (27.4%) subjects had transient severe @entity12 caused by @entity5 (N  =  19), antidepressant (N  =  18), @entity13 and @entity3 for @entity9 (N  =  15), hormone replacement therapy for @entity0 (N  =  9), b-blocker (N  =  5), @entity10 (N  =  4), pregnancy (N  =  4), and @entity14 (N  =  2). As many as 119 (55.3%) subjects exhibited @entity11 . Moreover, 12 (5.6%) and 17 (7.9%) subjects had a history of @entity8 and @entity7 , respectively. CONCLUSIONS: A variety of situations can cause severe @entity12 . We suggest that potential secondary causes should be carefully assessed for such @entity1 .

title: Clinical characteristics of Japanese @entity1 with severe XXXX .

answer: @entity12


abstract: BACKGROUND: Although of interest, few data exist on the clinical characteristics of Japanese @entity1 with an extremely high @entity6 level (>= 1000  mg/dL). OBJECTIVE: We assessed the clinical characteristics of Japanese @entity1 with an extremely high @entity6 level. METHODS: We investigated the presence of @entity7 , history of @entity8 , the presence of @entity11 , and the potential causes of elevated @entity6 in Japanese subjects with an extremely high level of fasting @entity6 (>= 1000  mg/dL) among 70,368 subjects whose serum @entity6 was measured for any reason at Kanazawa University Hospital from April 2004 to March  2014. RESULTS: We identified 215 (0.31%) subjects (mean age, 46  years; male, 170, mean body mass index, 25  kg/m(2)) with severe @entity12 . Among them, 4 (1.9%) subjects were classified as type I, 97 (45.1%) subjects were type IV, and 114 (53.0%) subjects were @entity15 , according to Fredrickson's classification. Among 215 subjects, 116 subjects (54.0%) drank @entity4 , 58 (27.0%) showed heavy intake (>= 60  g/d), and 64 (29.8%) subjects had @entity2 . In total, 59 (27.4%) subjects had transient severe @entity12 caused by @entity5 (N  =  19), antidepressant (N  =  18), @entity13 and @entity3 for @entity9 (N  =  15), hormone replacement therapy for @entity0 (N  =  9), b-blocker (N  =  5), @entity10 (N  =  4), pregnancy (N  =  4), and @entity14 (N  =  2). As many as 119 (55.3%) subjects exhibited @entity11 . Moreover, 12 (5.6%) and 17 (7.9%) subjects had a history of @entity8 and @entity7 , respectively. CONCLUSIONS: A variety of situations can cause severe @entity12 . We suggest that potential secondary causes should be carefully assessed for such @entity1 .

title: Clinical characteristics of Japanese XXXX with severe @entity12 .

answer: @entity1