abstract: BACKGROUND: @entity5 is reported in up to 7.8% of @entity0 with @entity1 . A distinct @entity1 phenotype has been suggested in adults and in small pediatric cohorts. AIMS: To evaluate the features of @entity1 associated with @entity5 and to analyze the characteristics of the @entity5 . METHODS: Information on @entity0 was obtained from the Italian Pediatric @entity1 Registry. Data of @entity0 with and without @entity5 were compared. RESULTS: @entity5 was detected in 6.8% of the 677 @entity0 enrolled and was significantly associated with the diagnosis of @entity2 (83%), with @entity6 (84%), and with perinuclear anti-neutrophil cytoplasmic antibody positivity (41%) (all ps < 0.05). @entity5 was defined as sclerosing @entity4 in 61% of the @entity0 and as an overlap syndrome in 33%. Concomitant intra and extrahepatic biliary involvement was reported in 61% of cases, while exclusive @entity3 were reported in 21%. Hepatobiliary complications were observed in 9% of the @entity0 during follow-up. CONCLUSIONS: @entity5 , especially sclerosing @entity4 , was significantly more common in @entity0 with extensive @entity2 . Although complications are relatively rare in the pediatric age, monitoring is recommended.

title: Clinical Features and Risk Factors of Autoimmune Liver Involvement in Pediatric XXXX .

answer: @entity1


abstract: UNASSIGNED: Several studies have investigated the effects of fish oil (FO) on @entity0 growth, but little is known about the effects of FO and sex on @entity1 ( @entity1 ), the main regulator of growth in childhood. We explored whether FO v. sunflower oil (SO) supplementation from 9 to 18 months of age affected @entity1 and its binding protein-3 ( @entity2 ) and whether the potential effects were sex specific. Danish @entity0 (n 115) were randomly allocated to 5 ml/d FO (1  2 g/d n-3 long-chain PUFA (n-3 LCPUFA)) or SO. We measured growth, @entity1 , @entity2 and erythrocyte EPA, a biomarker of n-3 LCPUFA intake and status, at 9 and 18 months. Erythrocyte @entity3 increased strongly with FO compared with SO (P<0  001). There were no effects of FO compared with SO on @entity1 in the total population, but a sex*group interaction (P=0  02). Baseline-adjusted @entity1 at 18 months was 11  1   g/l (95 % CI 0  4, 21  8; P=0  04) higher after FO compared with SO supplementation among @entity0 only. The sex*group interaction was borderline significant in the model of @entity2 (P=0  09), with lower @entity2 with FO compared with SO among @entity0 only (P=0  03). The results were supported by sex-specific dose-response associations between changes in erythrocyte EPA and changes in @entity1 and @entity2 (both P<0  03). Moreover, @entity1 was sex specifically associated with BMI and length. In conclusion, FO compared with SO resulted in higher @entity1 among @entity0 and lower @entity2 among @entity0 . The potential long-term implications for growth and body composition should be investigated further.

title: Fish oil supplementation from 9 to 18 months of age affects the insulin-like growth factor axis in a sex-specific manner in Danish XXXX .

answer: @entity0


abstract: UNASSIGNED: Ventriculoperitoneal (VP) shunt insertion is a common neurosurgical procedure, essentially unchanged in recent years, with high revision rates. We aimed to identify potentially modifiable associations with shunt failure. One hundred and forty @entity0 who underwent insertion of a VP shunt from 2005-2009 were followed for 5-9years. Age at shunt insertion ranged from 0 to 91years (median 44, 26% <18years). The main causes of @entity4 were congenital (26%), @entity1 -related (25%), post- @entity3 (24%) or normal pressure @entity4 (19%). Fifty-eight (42%) @entity0 required    1 shunt revision. Of these, 50 (88%) were for proximal catheter blockage. The median time to first revision was 108days. Early post-operative CT scans were available in 105 @entity0 . Using a formal grading system, catheter placement was considered excellent in 49 (47%) but poor (extraventricular) in 13 (12%). On univariate analysis, younger age, poor ventricular catheter placement and use of a non-programmable valve were associated with shunt failure. On logistic regression modelling, the independent associations with VP shunt failure were poor catheter placement (odds ratio [OR] 4.9, 95% confidence interval [CI] 1.3-18.9, p=0.02) and use of a non-programmable valve (OR 0.4, 95% CI 0.2-1.0, p=0.04). In conclusion, poor catheter placement (revision rate 77%) was found to be the strongest predictor of shunt failure, with no difference in revisions between excellent (43%) and moderate (43%) catheter placement. Avoiding poor placement in those with mild or moderate @entity4 may best reduce @entity2 . There may also be an influence of valve choice on VP shunt survival.

title: Choice of valve type and poor ventricular catheter placement: Modifiable factors associated with XXXX .

answer: @entity2


abstract: Th1 cell activation and cytokine production shift the balance between Th1 and Th2, favoring the upregulation of proinflammatory activity that leads to destruction of allogeneic hepatocytes following transplantation. Th2-type cytokines. such as @entity1 , have immune regulatory function. The aim of this study was to determine the antirejection efficacy of allogeneic hepatocytes with spheroidal shape (spheroids) genetically modified with viral @entity1 ( @entity2 -10). Allogeneic hepatocyte spheroids, transferred @entity2 -10 gene by using adenovirus as the vector, were transplanted into the spleen of Nagase's analbuminemic @entity0 (NAR). NAR transplanted with @entity2 -10-transfected hepatocytes showed an abrupt rise in serum albumin levels that peaked on day 7 and remained at high levels up to day 21 after transplantation. The peak level of albumin on day 7 in @entity2 -10-transfected NAR was eminently higher than that in nontransfected NAR. Histopathological analysis revealed that in nontransfected NAR hepatocyte spheroids were more or less rejected on day 4, and, in contrast, @entity2 -10-transfected spheroids were still not rejected on day 14. This protective effect correlated with sustained high @entity2 -10 level in the splenic vein in NAR transplanted with @entity2 -10-transfected hepatocyte spheroids, suggesting that @entity2 -10 secreted from the transplanted hepatocytes induced an active suppression of allogeneic response. This study provides evidence to support the possibility of using @entity2 -10 gene therapy to prevent allogeneic response in hepatocyte transplantation.

title: Suppression of allogeneic response by viral XXXX gene transfer.

answer: @entity1


abstract: BACKGROUND: The Physiological and Operative Severity Score for enUmeration of Mortality and morbidity (POSSUM), which consists of a physiological score (PS) and an operative severity score, is useful in determining the risk profile for @entity0 with @entity3 in Western countries, but no information is available on the use of this method in Japan. METHODS AND RESULTS: A retrospective cohort study involving 225 @entity0 was performed, and the prognostic factors for morbidity and in-hospital mortality including POSSUM were investigated. The morbidity rate was 26%. On univariate analysis age, @entity1 , hemoglobin, albumin, operation time, @entity2 and PS were significantly different. On multivariate analysis PS was significantly different. Using receiver operating characteristic (ROC) analysis, PS had an area under the curve (AUC) of 0.712 and the best cut-off point was 18. The in-hospital mortality rate was 2.2%. On univariate analysis @entity1 , albumin and PS were significantly different, and on multivariate analysis PS was significantly different. On ROC analysis PS had an AUC of 0.921 and the best cut-off point was 22. CONCLUSIONS: PS was the only independent risk factor for morbidity and in-hospital mortality. Further studies may be required to develop a risk-scoring system.

title: Usefulness of POSSUM physiological score for the estimation of morbidity and mortality risk after elective XXXX repair in Japan.

answer: @entity3


abstract: BACKGROUND: Despite anticoagulant therapy, many @entity0 with @entity1 and @entity2 develop @entity3 . These @entity0 have a high risk of @entity5 , but the etiology is not clear. We studied autonomic function and the possibility of malignant @entity4 through heart rate variability. METHODS: We studied six @entity1 @entity0 with @entity3 and 16 normal controls. Heart rate variability was investigated using a 24 h electrocardiogram. We assessed the standard deviation from the mean of the normal R-R intervals (SDNN), the proportion of adjacent R-R intervals with a difference greater than 50 msec (pNN50) and the root-mean square of successive R-R differences as time-domain analysis (rMSSD). We assessed very low-frequency power, low-frequency power (LF), high-frequency power (HF) and the LF/HF ratio in frequency-domain analysis. RESULTS: There was no significant difference in SDNN, but there was a significant difference in pNN50 and rMSSD. @entity0 with @entity1 showed lower HF and higher LF/HF than normal controls. CONCLUSION: Our findings suggest that @entity0 with @entity1 and @entity3 show decreased vagal activity, which could cause malignant @entity4 .

title: Autonomic function in XXXX with @entity3 : usefulness of monitoring heart rate variability.

answer: @entity1


abstract: BACKGROUND: Despite anticoagulant therapy, many @entity0 with @entity1 and @entity2 develop @entity3 . These @entity0 have a high risk of @entity5 , but the etiology is not clear. We studied autonomic function and the possibility of malignant @entity4 through heart rate variability. METHODS: We studied six @entity1 @entity0 with @entity3 and 16 normal controls. Heart rate variability was investigated using a 24 h electrocardiogram. We assessed the standard deviation from the mean of the normal R-R intervals (SDNN), the proportion of adjacent R-R intervals with a difference greater than 50 msec (pNN50) and the root-mean square of successive R-R differences as time-domain analysis (rMSSD). We assessed very low-frequency power, low-frequency power (LF), high-frequency power (HF) and the LF/HF ratio in frequency-domain analysis. RESULTS: There was no significant difference in SDNN, but there was a significant difference in pNN50 and rMSSD. @entity0 with @entity1 showed lower HF and higher LF/HF than normal controls. CONCLUSION: Our findings suggest that @entity0 with @entity1 and @entity3 show decreased vagal activity, which could cause malignant @entity4 .

title: Autonomic function in @entity1 with XXXX : usefulness of monitoring heart rate variability.

answer: @entity3


abstract: The relationship between antibiotic consumption and selection of resistant strains has been studied mainly by employing conventional statistical methods. A time delay in effect must be anticipated and this has rarely been taken into account in previous studies. Therefore, distributed lags time series analysis and simple linear correlation were compared in their ability to evaluate this relationship. Data on monthly antibiotic consumption for @entity1 , @entity3 / @entity5 , carbapenems and cefepime as well as @entity0 susceptibility were retrospectively collected for the period April 2006 to July 2007. Using distributed lags analysis, a significant temporal relationship was identified between @entity1 , @entity2 and cefepime consumption and the resistance rates of @entity0 isolates to these antibiotics. This effect was lagged for @entity1 and @entity4 [1 month (R=0.827, P=0.039) and 2 months (R=0.962, P=0.001), respectively] and was simultaneous for @entity2 (lag 0, R=0.876, P=0.002). Furthermore, a significant concomitant effect of @entity2 consumption on the appearance of multidrug-resistant @entity0 strains (resistant to three or more representatives of classes of antibiotics) was identified (lag 0, R=0.992, P<0.001). This effect was not delayed and it was therefore identified both by distributed lags analysis and the Pearson's correlation coefficient. Correlation coefficient analysis was not able to identify relationships between antibiotic consumption and bacterial resistance when the effect was delayed. These results indicate that the use of diverse statistical methods can yield significantly different results, thus leading to the introduction of possibly inappropriate infection control measures.

title: Distributed lags time series analysis versus linear correlation analysis (Pearson's r) in identifying the relationship between antipseudomonal antibiotic consumption and the susceptibility of XXXX isolates in a single Intensive Care Unit of a tertiary hospital.

answer: @entity0


abstract: OBJECTIVE: We evaluate presentation and outcome of @entity0 with metastatic @entity3 from our institution and published literature. METHODS: @entity0 with a history of @entity3 @entity1 from @entity4 were selected from our institution's prospective database. A systematic PubMed search was performed to identify articles describing @entity0 with metastatic @entity3 . The final cohort included 33 @entity0 : 4 from our institution and 29 from 28 previously published cases. Survival analysis was conducted using log-rank Kaplan-Meier analysis. RESULTS: Median @entity0 age was 63 years and the majority of @entity0 were male. Most @entity0 were asymptomatic and diagnosed with @entity3 @entity1 on imaging performed for surveillance or staging. The median time to @entity3 @entity1 following nephrectomy was 4 years. @entity1 to the @entity3 occurred both synchronously (33%) and metachronously (67%). Of the @entity0 with available histology, all had clear cell @entity4 (n = 28). Of all @entity0 , 13 (39%) had @entity1 only to the @entity3 , while 20 (61%) had additional sites of @entity1 . The most common sites of additional @entity1 were contralateral kidney (30%), pancreas (21%), lung (18%), adrenal (18%), and lymph nodes (9%). All @entity0 underwent cholecystectomy. At a median follow up time of 1.5 years after cholecystectomy, 54% of @entity0 had no evidence of disease, 14% were alive with @entity1 , 23% had died from metastatic @entity4 , and 9% died from causes unrelated to their @entity2 . CONCLUSION: Gallbladder @entity1 from @entity4 is a rare event that may occur synchronously or metachronously with most @entity0 being asymptomatic. @entity4 appears to be the primary pathology associated with @entity3 @entity1 . High rates of bilateral @entity4 and pancreatic @entity1 suggest novel associations in @entity0 with @entity4 and @entity3 @entity1 .

title: @entity4 with @entity1 to the XXXX : four cases from the National @entity2 Institute (NCI) and review of the literature.

answer: @entity3


abstract: OBJECTIVE: We evaluate presentation and outcome of @entity0 with metastatic @entity3 from our institution and published literature. METHODS: @entity0 with a history of @entity3 @entity1 from @entity4 were selected from our institution's prospective database. A systematic PubMed search was performed to identify articles describing @entity0 with metastatic @entity3 . The final cohort included 33 @entity0 : 4 from our institution and 29 from 28 previously published cases. Survival analysis was conducted using log-rank Kaplan-Meier analysis. RESULTS: Median @entity0 age was 63 years and the majority of @entity0 were male. Most @entity0 were asymptomatic and diagnosed with @entity3 @entity1 on imaging performed for surveillance or staging. The median time to @entity3 @entity1 following nephrectomy was 4 years. @entity1 to the @entity3 occurred both synchronously (33%) and metachronously (67%). Of the @entity0 with available histology, all had clear cell @entity4 (n = 28). Of all @entity0 , 13 (39%) had @entity1 only to the @entity3 , while 20 (61%) had additional sites of @entity1 . The most common sites of additional @entity1 were contralateral kidney (30%), pancreas (21%), lung (18%), adrenal (18%), and lymph nodes (9%). All @entity0 underwent cholecystectomy. At a median follow up time of 1.5 years after cholecystectomy, 54% of @entity0 had no evidence of disease, 14% were alive with @entity1 , 23% had died from metastatic @entity4 , and 9% died from causes unrelated to their @entity2 . CONCLUSION: Gallbladder @entity1 from @entity4 is a rare event that may occur synchronously or metachronously with most @entity0 being asymptomatic. @entity4 appears to be the primary pathology associated with @entity3 @entity1 . High rates of bilateral @entity4 and pancreatic @entity1 suggest novel associations in @entity0 with @entity4 and @entity3 @entity1 .

title: @entity4 with XXXX to the @entity3 : four cases from the National @entity2 Institute (NCI) and review of the literature.

answer: @entity1


abstract: OBJECTIVE: We evaluate presentation and outcome of @entity0 with metastatic @entity3 from our institution and published literature. METHODS: @entity0 with a history of @entity3 @entity1 from @entity4 were selected from our institution's prospective database. A systematic PubMed search was performed to identify articles describing @entity0 with metastatic @entity3 . The final cohort included 33 @entity0 : 4 from our institution and 29 from 28 previously published cases. Survival analysis was conducted using log-rank Kaplan-Meier analysis. RESULTS: Median @entity0 age was 63 years and the majority of @entity0 were male. Most @entity0 were asymptomatic and diagnosed with @entity3 @entity1 on imaging performed for surveillance or staging. The median time to @entity3 @entity1 following nephrectomy was 4 years. @entity1 to the @entity3 occurred both synchronously (33%) and metachronously (67%). Of the @entity0 with available histology, all had clear cell @entity4 (n = 28). Of all @entity0 , 13 (39%) had @entity1 only to the @entity3 , while 20 (61%) had additional sites of @entity1 . The most common sites of additional @entity1 were contralateral kidney (30%), pancreas (21%), lung (18%), adrenal (18%), and lymph nodes (9%). All @entity0 underwent cholecystectomy. At a median follow up time of 1.5 years after cholecystectomy, 54% of @entity0 had no evidence of disease, 14% were alive with @entity1 , 23% had died from metastatic @entity4 , and 9% died from causes unrelated to their @entity2 . CONCLUSION: Gallbladder @entity1 from @entity4 is a rare event that may occur synchronously or metachronously with most @entity0 being asymptomatic. @entity4 appears to be the primary pathology associated with @entity3 @entity1 . High rates of bilateral @entity4 and pancreatic @entity1 suggest novel associations in @entity0 with @entity4 and @entity3 @entity1 .

title: XXXX with @entity1 to the @entity3 : four cases from the National @entity2 Institute (NCI) and review of the literature.

answer: @entity4


abstract: OBJECTIVE: We evaluate presentation and outcome of @entity0 with metastatic @entity3 from our institution and published literature. METHODS: @entity0 with a history of @entity3 @entity1 from @entity4 were selected from our institution's prospective database. A systematic PubMed search was performed to identify articles describing @entity0 with metastatic @entity3 . The final cohort included 33 @entity0 : 4 from our institution and 29 from 28 previously published cases. Survival analysis was conducted using log-rank Kaplan-Meier analysis. RESULTS: Median @entity0 age was 63 years and the majority of @entity0 were male. Most @entity0 were asymptomatic and diagnosed with @entity3 @entity1 on imaging performed for surveillance or staging. The median time to @entity3 @entity1 following nephrectomy was 4 years. @entity1 to the @entity3 occurred both synchronously (33%) and metachronously (67%). Of the @entity0 with available histology, all had clear cell @entity4 (n = 28). Of all @entity0 , 13 (39%) had @entity1 only to the @entity3 , while 20 (61%) had additional sites of @entity1 . The most common sites of additional @entity1 were contralateral kidney (30%), pancreas (21%), lung (18%), adrenal (18%), and lymph nodes (9%). All @entity0 underwent cholecystectomy. At a median follow up time of 1.5 years after cholecystectomy, 54% of @entity0 had no evidence of disease, 14% were alive with @entity1 , 23% had died from metastatic @entity4 , and 9% died from causes unrelated to their @entity2 . CONCLUSION: Gallbladder @entity1 from @entity4 is a rare event that may occur synchronously or metachronously with most @entity0 being asymptomatic. @entity4 appears to be the primary pathology associated with @entity3 @entity1 . High rates of bilateral @entity4 and pancreatic @entity1 suggest novel associations in @entity0 with @entity4 and @entity3 @entity1 .

title: @entity4 with @entity1 to the @entity3 : four cases from the National XXXX Institute (NCI) and review of the literature.

answer: @entity2


abstract: UNASSIGNED: Mitochondrial protein homeostasis is crucial for cellular function and integrity and is therefore maintained by several classes of proteins possessing chaperone and/or proteolytic activities. In this work we focused on characterization of @entity4 (lactation elevated 1) function in mitochondrial protein homeostasis maintenance. @entity4 is the @entity0 homologue of @entity1 mitochondrial @entity7 ATPase, a member of SEC18-NSF, @entity8 , @entity2 -VCP, TBP family. @entity1 @entity7 was shown to mediate degradation of mitochondrially-encoded complex IV subunits, and based on its similarity with @entity2 (p97/VCP) it was suggested to facilitate extraction of polytopic membrane proteins. Here we show that @entity4 , which is a mitochondrial integral membrane protein, exists as part of three complexes of approx. 140, 400 and 500 kDa and is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. We demonstrate that @entity4 mediates degradation of nuclear-encoded complex IV subunits @entity3 , @entity5 and COX6A, and is required for normal activity of complexes III and IV of respiratory chain. Using affinity purification of @entity4 -FLAG expressed in @entity4 knockdown background we show that the protein physically interacts with @entity3 and @entity5 subunits of complex IV and with mitochondrial inner-membrane protease YME1L. Finally, we demonstrate by ectopic expression of both @entity6 Walker A and @entity9 Walker B mutants, that an intact ATPase domain is essential for @entity4 -mediated degradation of nuclear-encoded complex IV subunits. Thus, our work establishes @entity4 as a novel factor with crucial role in mitochondrial protein homeostasis maintenance.

title: The @entity0 homologue of XXXX @entity7 ATPase (Lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.

answer: @entity1


abstract: UNASSIGNED: Mitochondrial protein homeostasis is crucial for cellular function and integrity and is therefore maintained by several classes of proteins possessing chaperone and/or proteolytic activities. In this work we focused on characterization of @entity4 (lactation elevated 1) function in mitochondrial protein homeostasis maintenance. @entity4 is the @entity0 homologue of @entity1 mitochondrial @entity7 ATPase, a member of SEC18-NSF, @entity8 , @entity2 -VCP, TBP family. @entity1 @entity7 was shown to mediate degradation of mitochondrially-encoded complex IV subunits, and based on its similarity with @entity2 (p97/VCP) it was suggested to facilitate extraction of polytopic membrane proteins. Here we show that @entity4 , which is a mitochondrial integral membrane protein, exists as part of three complexes of approx. 140, 400 and 500 kDa and is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. We demonstrate that @entity4 mediates degradation of nuclear-encoded complex IV subunits @entity3 , @entity5 and COX6A, and is required for normal activity of complexes III and IV of respiratory chain. Using affinity purification of @entity4 -FLAG expressed in @entity4 knockdown background we show that the protein physically interacts with @entity3 and @entity5 subunits of complex IV and with mitochondrial inner-membrane protease YME1L. Finally, we demonstrate by ectopic expression of both @entity6 Walker A and @entity9 Walker B mutants, that an intact ATPase domain is essential for @entity4 -mediated degradation of nuclear-encoded complex IV subunits. Thus, our work establishes @entity4 as a novel factor with crucial role in mitochondrial protein homeostasis maintenance.

title: The @entity0 homologue of @entity1 XXXX ATPase (Lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.

answer: @entity7


abstract: UNASSIGNED: Mitochondrial protein homeostasis is crucial for cellular function and integrity and is therefore maintained by several classes of proteins possessing chaperone and/or proteolytic activities. In this work we focused on characterization of @entity4 (lactation elevated 1) function in mitochondrial protein homeostasis maintenance. @entity4 is the @entity0 homologue of @entity1 mitochondrial @entity7 ATPase, a member of SEC18-NSF, @entity8 , @entity2 -VCP, TBP family. @entity1 @entity7 was shown to mediate degradation of mitochondrially-encoded complex IV subunits, and based on its similarity with @entity2 (p97/VCP) it was suggested to facilitate extraction of polytopic membrane proteins. Here we show that @entity4 , which is a mitochondrial integral membrane protein, exists as part of three complexes of approx. 140, 400 and 500 kDa and is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. We demonstrate that @entity4 mediates degradation of nuclear-encoded complex IV subunits @entity3 , @entity5 and COX6A, and is required for normal activity of complexes III and IV of respiratory chain. Using affinity purification of @entity4 -FLAG expressed in @entity4 knockdown background we show that the protein physically interacts with @entity3 and @entity5 subunits of complex IV and with mitochondrial inner-membrane protease YME1L. Finally, we demonstrate by ectopic expression of both @entity6 Walker A and @entity9 Walker B mutants, that an intact ATPase domain is essential for @entity4 -mediated degradation of nuclear-encoded complex IV subunits. Thus, our work establishes @entity4 as a novel factor with crucial role in mitochondrial protein homeostasis maintenance.

title: The XXXX homologue of @entity1 @entity7 ATPase (Lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.

answer: @entity0


abstract: We report a 16 years old @entity0 with diagnosis of @entity6 with severe immune suppression secondary to his @entity5 's treatment. Early during the course of his chemotherapy he developed symptoms and signs compatible with @entity2 ( @entity2 ). Lungs were primarily compromised followed by CNS involvement with manifestations of @entity3 . Laboratory exams were remarkable for prolonged @entity4 and indirect evidence of @entity1 , with successive detection of positive and increasing levels of galactoman antigen in serum. With this case we want emphasize the great importance of @entity2 in immune suppressed @entity0 and particularly the CNS compromise. This represents a medical emergency which deserves to start a complete and comprehensive microbiology diagnosis and concomitantly start an empiric antifungal treatment. The importance of neuroimaging for a correct identification of the number, location and size of CNS lesions must be highlighted. The election of MRI, if available, should be preferred due to a better performance than CT scan. Brain biopsy should be discussed when all the non invasive attempts for etiology identification have failed. The invasive fungal CNS compromise has medical treatment and the surgical drainage has to be considered for lesions greater than 2 cm or for those making a mass effect or have failed with medical treatment.

title: [Importance of images and etiological diagnosis of central nervous system involvement in immunocompromised XXXX ].

answer: @entity0


abstract: BACKGROUND: @entity1 is the result of an interplay of many different cell types, including basophils and mast cells, in combination with various inflammatory lipid mediators, such as platelet-activating factor ( @entity8 ) and @entity5 (LT). LTC4 synthesis by @entity0 basophils has been studied quite extensively. However, not much is known about the synthesis of @entity8 by @entity0 basophils. OBJECTIVE: In this study, we have made a comprehensive comparison between the kinetics of @entity8 and LTC4 synthesis, in highly purified basophils, activated with different stimuli or with combinations of stimuli. METHODS: Synthesis of @entity8 and LTC4 by @entity0 basophils was determined with commercially available assay kits. The basophils were activated with C5a, @entity7 , @entity6 , allergen or anti-IgE, in the absence and presence of @entity4 and/or in combination with elevation of cytosolic free @entity2 by the sarcoplasmic reticulum @entity2 -ATPase inhibitor @entity3 . RESULTS: Most stimuli were found to induce both @entity8 and LTC4 synthesis. @entity8 synthesis and LTC4 release were enhanced by preincubation of the basophils with @entity4 or by elevation of cytosolic free @entity2 by @entity3 . Incubation of @entity0 basophils with @entity4 alone or @entity3 alone did not result in detectable synthesis of @entity8 and LTC4, whereas the combination of the two resulted in high amounts of @entity8 and LTC4 synthesis. Depending on the stimulus used, LTC4 release was 5-100-fold higher than @entity8 synthesis. In addition, @entity8 , but not LTC4, was transiently detected, probably due to @entity8 degradation. LTC4 and @entity8 synthesis was strongly blocked by inhibitors of cytosolic phospholipase A2, indicating that this enzyme is involved in @entity8 and LTC4 synthesis by activated @entity0 basophils. CONCLUSION: This study provides a first comprehensive comparison of @entity8 and LTC4 synthesis in highly purified @entity0 basophils, stimulated with a variety of stimuli.

title: Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated XXXX basophils.

answer: @entity0


abstract: We use asexual development of @entity2 as a model system with which to determine the causes of cell differentiation. Air exposure of a mycelial mat induces @entity1 , and adherent hyphae grow aerial hyphae that, in turn, form conidia. Previous work indicated the development of a hyperoxidant state at the start of these morphogenetic transitions and a large increase in catalase activity during conidiation. Catalase 3 (CAT-3) increases at the end of exponential growth and is induced by different stress conditions. Here we analyzed the effects of cat-3-null strains on growth and asexual development. The lack of CAT-3 was not compensated by other catalases, even under oxidative stress conditions, and cat-3(RIP) colonies were sensitive to @entity0 , indicating that wild-type (Wt) resistance to external @entity0 was due to CAT-3. cat-3(RIP) colonies grown in the dark produced high levels of @entity3 as a consequence of oxidative stress. Light exacerbated oxidative stress and further increased carotene synthesis. In the cat-3(RIP) mutant strain, increased aeration in liquid cultures led to increased @entity1 and protein oxidation. Compared to the Wt, the cat-3(RIP) mutant strain produced six times more aerial hyphae and conidia in air-exposed mycelial mats, as a result of longer and more densely packed aerial hyphae. Protein oxidation in colonies was threefold higher and showed more aerial hyphae and conidia in mutant strains than did the Wt. Results indicate that oxidative stress due to lack of CAT-3 induces carotene synthesis, @entity1 , and more aerial hyphae and conidia.

title: Asexual development is increased in XXXX cat-3-null mutant strains.

answer: @entity2


abstract: PURPOSE: A preliminary evaluation of the efficacy of @entity5 in @entity0 with @entity1 demonstrated modest activity. A markedly lower than expected incidence of drug-related @entity3 was also noted. This was consistent with pharmacokinetic data indicating that the total body clearance (CL) of @entity5 in this @entity0 population was considerably greater than in @entity2 @entity0 . Concomitant medications used chronically in @entity4 @entity0 , especially glucocorticoids and anticonvulsants that induce hepatic enzymes involved in the metabolism or excretion of drugs, were believed to be the cause of the alteration in pharmacokinetic behavior. A Phase I study was therefore undertaken in @entity0 with recurrent @entity1 to independently determine the maximum tolerated dose (MTD) of @entity5 in @entity0 stratified according to the use of enzyme-inducing anticonvulsants (EIAs). EXPERIMENTAL DESIGN: @entity0 with recurrent @entity1 received @entity5 as a weekly 90-min i.v. infusion for four consecutive weeks, with additional cycles of treatment repeated every 6 weeks. The starting dose was 125 mg/m(2)/week for both groups of @entity0 (+/-EIA). Groups of >/==" BORDER="0">3 @entity0 were evaluated at each dose level, and the modified continual reassessment method was used for dose adjustments. The plasma pharmacokinetics of @entity5 , its active metabolite, @entity5 ( @entity5 ), and the glucuronide conjugate of @entity5 , @entity5 glucuronide, were determined in all @entity0 during treatment with the first weekly dose. RESULTS: Forty @entity0 were enrolled into the study and treated with a total of 135 cycles of @entity5 . The MTD was determined to be 411 mg/m(2)/week in the +EIA cohort and 117 mg/m(2)/week in the -EIA cohort for the weekly x 4 every 6 weeks schedule. Pharmacokinetic studies showed that the CL of @entity5 was distinctly dose dependent in the @entity0 receiving EIAs, decreasing from approximately 50 liters/h/m(2) at the lower dose levels (125-238 mg/m(2)) to a mean +/- SD value of 29.7 +/- 9.0 liters/h/m(2) (n = 7) at the MTD. The grand mean CL for a group of 13 @entity0 who were not taking EIAs, 18.8 +/- 10.6 liters/h/m(2), was significantly different from the mean CL at the MTD of the +EIA cohort (P = 0.033). Mean values of the AUC of @entity5 (P = 0.4) and @entity6 (P = 0.55) were not significantly different at the MTDs for the two cohorts of @entity0 . CONCLUSIONS: The MTD of @entity5 was 3.5 times greater in @entity0 with @entity1 who were concurrently receiving EIAs than in those who were not. This study has also served to confirm that the concomitant administration of EIAs results in marked enhancement in the CL of @entity5 . These findings have important implications for subsequent clinical trials to further evaluate @entity5 in @entity4 @entity0 and underscore the importance of assessing the potential for pharmacokinetic interactions between concurrent medications and chemotherapeutic agents.

title: Phase I clinical and pharmacokinetic study of @entity5 in adults with recurrent XXXX .

answer: @entity1


abstract: PURPOSE: A preliminary evaluation of the efficacy of @entity5 in @entity0 with @entity1 demonstrated modest activity. A markedly lower than expected incidence of drug-related @entity3 was also noted. This was consistent with pharmacokinetic data indicating that the total body clearance (CL) of @entity5 in this @entity0 population was considerably greater than in @entity2 @entity0 . Concomitant medications used chronically in @entity4 @entity0 , especially glucocorticoids and anticonvulsants that induce hepatic enzymes involved in the metabolism or excretion of drugs, were believed to be the cause of the alteration in pharmacokinetic behavior. A Phase I study was therefore undertaken in @entity0 with recurrent @entity1 to independently determine the maximum tolerated dose (MTD) of @entity5 in @entity0 stratified according to the use of enzyme-inducing anticonvulsants (EIAs). EXPERIMENTAL DESIGN: @entity0 with recurrent @entity1 received @entity5 as a weekly 90-min i.v. infusion for four consecutive weeks, with additional cycles of treatment repeated every 6 weeks. The starting dose was 125 mg/m(2)/week for both groups of @entity0 (+/-EIA). Groups of >/==" BORDER="0">3 @entity0 were evaluated at each dose level, and the modified continual reassessment method was used for dose adjustments. The plasma pharmacokinetics of @entity5 , its active metabolite, @entity5 ( @entity5 ), and the glucuronide conjugate of @entity5 , @entity5 glucuronide, were determined in all @entity0 during treatment with the first weekly dose. RESULTS: Forty @entity0 were enrolled into the study and treated with a total of 135 cycles of @entity5 . The MTD was determined to be 411 mg/m(2)/week in the +EIA cohort and 117 mg/m(2)/week in the -EIA cohort for the weekly x 4 every 6 weeks schedule. Pharmacokinetic studies showed that the CL of @entity5 was distinctly dose dependent in the @entity0 receiving EIAs, decreasing from approximately 50 liters/h/m(2) at the lower dose levels (125-238 mg/m(2)) to a mean +/- SD value of 29.7 +/- 9.0 liters/h/m(2) (n = 7) at the MTD. The grand mean CL for a group of 13 @entity0 who were not taking EIAs, 18.8 +/- 10.6 liters/h/m(2), was significantly different from the mean CL at the MTD of the +EIA cohort (P = 0.033). Mean values of the AUC of @entity5 (P = 0.4) and @entity6 (P = 0.55) were not significantly different at the MTDs for the two cohorts of @entity0 . CONCLUSIONS: The MTD of @entity5 was 3.5 times greater in @entity0 with @entity1 who were concurrently receiving EIAs than in those who were not. This study has also served to confirm that the concomitant administration of EIAs results in marked enhancement in the CL of @entity5 . These findings have important implications for subsequent clinical trials to further evaluate @entity5 in @entity4 @entity0 and underscore the importance of assessing the potential for pharmacokinetic interactions between concurrent medications and chemotherapeutic agents.

title: Phase I clinical and pharmacokinetic study of XXXX in adults with recurrent @entity1 .

answer: @entity5


abstract: BACKGROUND AND OBJECTIVE: Body-image issues associated with dermatological side effects induced by anticancer-targeted therapies have not been specifically explored until now despite growing literature about their impact on quality of life. Prospective and longitudinal investigations were needed. The aim of our study was to describe body-image changes occurring with cutaneous @entity1 and their psychosocial impact on @entity0 . @entity0 AND METHODS: Thirty-three @entity0 were evaluated four times during the first 3  months of targeted therapy in terms of body satisfaction, physical attitudes and @entity2 with validated and ad hoc questionnaires. The NCI-CTCAE V4.0 was used to grade adverse dermatological events. Descriptive and inferential analyses were conducted with SPSS 14.0 software. RESULTS: Ninety-four per cent of the @entity0 developed @entity1 . Body satisfaction remained stable and slightly better than average over this period. About one-third of the @entity0 reported body-image issues at baseline. Body satisfaction and @entity2 levels at baseline appeared to be significantly associated with body-image issues after 3  months of therapy. CONCLUSION: In the framework of regular dermatological monitoring, @entity1 did not appear to be associated with body-image issues. Body satisfaction and depressive symptoms at the beginning of targeted therapy emerged as critical factors that practitioners should consider in order to prevent deterioration of body image that could impact on quality of life and compromise compliance.

title: Impact of Skin XXXX Associated with Targeted Cancer Therapies on Body Image: A Prospective Study.

answer: @entity1


abstract: OBJECTIVE: To investigate alterations in protein kinases and phosphatases that regulate the activity of mitogen activated protein kinase (MAPK) in @entity2 ( @entity2 ). BACKGROUND: In vacuolated fibers in @entity2 , several studies reported upregulation of the @entity1 ( @entity1 ) subclass of MAPK family. Whereas MAPK kinases (MKK) activate MAPK, MAPK phosphatases (MKP) inactivate MAPK. @entity4 is involved in muscle fiber differentiation and it is downregulated during myotube formation. METHODS: Immunolocalization of @entity3 through @entity6 and @entity4 to @entity7 was tested in muscle specimens from 10 @entity0 with @entity2 and controls. RESULTS: In @entity2 , strong and focal deposits of @entity4 were observed in vacuolated fibers. The @entity4 -positive deposits were colocalized with @entity1 . @entity5 , @entity7 , and MKK were not associated with vacuolated fibers. CONCLUSIONS: In @entity2 , @entity4 is abnormally induced in vacuolated fibers probably to inactivate @entity1 . Although direct activators other than those tested in the current study might induce @entity1 , the absence of activation of MKK suggests that the aggregation of @entity1 protein itself causes the seeming upregulation of the protein kinase in @entity2 . Like @entity1 and its nuclear substrate, @entity4 is an enzyme that forms aggregates in vacuolated fibers and is involved in myogenesis.

title: @entity4 is induced in abnormal fibers in XXXX .

answer: @entity2


abstract: OBJECTIVE: To investigate alterations in protein kinases and phosphatases that regulate the activity of mitogen activated protein kinase (MAPK) in @entity2 ( @entity2 ). BACKGROUND: In vacuolated fibers in @entity2 , several studies reported upregulation of the @entity1 ( @entity1 ) subclass of MAPK family. Whereas MAPK kinases (MKK) activate MAPK, MAPK phosphatases (MKP) inactivate MAPK. @entity4 is involved in muscle fiber differentiation and it is downregulated during myotube formation. METHODS: Immunolocalization of @entity3 through @entity6 and @entity4 to @entity7 was tested in muscle specimens from 10 @entity0 with @entity2 and controls. RESULTS: In @entity2 , strong and focal deposits of @entity4 were observed in vacuolated fibers. The @entity4 -positive deposits were colocalized with @entity1 . @entity5 , @entity7 , and MKK were not associated with vacuolated fibers. CONCLUSIONS: In @entity2 , @entity4 is abnormally induced in vacuolated fibers probably to inactivate @entity1 . Although direct activators other than those tested in the current study might induce @entity1 , the absence of activation of MKK suggests that the aggregation of @entity1 protein itself causes the seeming upregulation of the protein kinase in @entity2 . Like @entity1 and its nuclear substrate, @entity4 is an enzyme that forms aggregates in vacuolated fibers and is involved in myogenesis.

title: XXXX is induced in abnormal fibers in @entity2 .

answer: @entity4


abstract: BACKGROUND: The association between @entity1 ( @entity1 ) and @entity3 is uncertain, and there is little data reported in Asia. This study examined the association of both diseases based on the computed tomographic colonography (CTC). METHODS: This study was designed as a case-control study. Korean subjects undergoing CTC between April 2002 to April 2008 in Samsung Medical Center were eligible. @entity0 with histologically proven @entity1 (case group) and asymptomatic age and gender matched controls (control group) were analyzed retrospectively. RESULTS: A total of 604 subjects were enrolled in this study (Case group N = 302, Control group N = 302). The case group was 54.6% male and the median age was 56.9 years old. Among them 24.5% of @entity1 @entity0 had @entity3 compared to 29.5% of controls (P = 0.169). The distribution of @entity3 between the two groups was similar. Subset analysis revealed no difference in the location of @entity3 in @entity0 with right @entity2 and left @entity2 (P = 0.781). CONCLUSIONS: This study indicates that @entity1 is not associated with @entity3 .

title: Association between XXXX and colonic diverticulosis: case-control study based on computed tomographic colonography.

answer: @entity1


abstract: OBJECTIVE: To investigate the feasibility of various molecular forms of hemoglobin as markers for fetal nucleated red blood cells (NRBCs). METHODS: The presence of epsilon and gamma globin positive NRBCs was investigated in pure fetal blood and in blood from pregnant @entity0 before and after chorion biopsy. Maternal samples were enriched for NRBCs by various conventional methods, including limited enrichment by only positive @entity2 selection or single density gradient. We searched for fetal cells on slides by automated scanning. Fetal cells were defined by (1) the presence of epsilon or gamma globin and (2) simultaneously by the presence of a Y chromosome signal. RESULTS: 18 of 25 gamma globin positive cells identified in blood samples after chorion biopsy were chromosome Y signal positive, and 1 cell had two X chromosome signals. 263 of 339 @entity1 positive cells identified in blood samples after chorion biopsy were hybridized with X and Y chromosome probes. None had two X signals, and 249 were Y positive. In blood samples before chorion biopsy, only 1 @entity1 positive fetal NRBC and no @entity1 positive maternal NRBCs were found. CONCLUSIONS: @entity1 may be specific for fetal NRBCs. Only 1 @entity1 positive fetal cell was identified in 1 of 12 blood samples before chorion biopsy, representing a total of 182 ml of maternal blood. This suggests that most fetal cells found in maternal blood by fluorescence in situ hybridization methods may not be NRBCs.

title: Studies on the isolation and identification of fetal nucleated red blood cells in the circulation of pregnant XXXX before and after chorion villus sampling.

answer: @entity0


abstract: During 1964 to 1967, a survey of 30,534 @entity0 for @entity2 was made on all over the country with the following results: 1. Among 24,816 draftees from all over the country in the army recruitment camp 155(0.63 %) were found infected with @entity1 . Cheju Do showed the highest microfilaria rate(3.5 %), North Kyongsang Do(1.4 %) the next and South Cholla Do(1.2 %) the third. 2. Blood films from 2,308 inhabitants were examined and 407(17.6 %) showed microfilaria in Cheju Do. 30(3.1 %) out of 974 inhabitants in North Kyongsang Do were found to be infected. The microfilaria rates were 2.0 per cent for 400 inhabitants of Chindo island in South Cholla Do. However, no positive case of microfilaria was found in the inhabitants of Kokumdo among 1,820 @entity0 examined in South Cholla Do and of Namhae island(among 165 @entity0 examined) in South Kyongsang Do. 3. The mean microfilarial density per 20 cu. mm of blood was 52.6 in the inhabitants of Cheju Do, 12.2 in North Kyongsang Do and 27.3 in Chindo island(South Cholla Do). 4. Any distinct relationship between the incidence of positive cases of microfilariae and age or sex of the cases was not observed in Cheju Do. However, in Norh Kyongsang Do and South Cholla Do the microfilaria rate of the male group is higher than the one of the female group of the inhabitants. 5. From the above survey results it turned out that @entity2 was found throughout Southern Korea except Kyonggi Do and South Kyongsang Do. A total 30,534 @entity0 examined, 601(2.0 %) were found to be infected by @entity1 . Therefore, it seems that there are some endemic foci of @entity2 in three main areas such as North Kyongsang Do, South Cholla Do and Cheju Do.

title: The Epidemiological Studies On The Filariasis In Korea: II. Distribution And Prevalence Of XXXX In Southern Korea.

answer: @entity2


abstract: PURPOSE: We obtained detailed information on the time and number of ejaculations to @entity1 after vasectomy by ligation and excision. MATERIALS AND METHODS: @entity0 seeking vasectomy at 3 public clinics in Mexico City were invited to participate in this prospective noncomparative study. Vasectomy was performed using the no-scalpel technique. The vas was occluded using 2 silk sutures and the segment of vas between the ligatures was excised. @entity0 were followed biweekly up to 24 weeks after vasectomy or until @entity1 was confirmed. Semen was examined at each visit for sperm concentration and motility. The main outcome measure was @entity1 in uncentrifuged semen samples. RESULTS: The life table rate for time to @entity1 was 81.5/100 @entity0 (95% CI 76.2 to 86.9) by the end of the study. Cumulative Kaplan-Meier event probability attained a maximum of 79.5/100 @entity0 (95% CI 73.7 to 85.2) at 70 ejaculations. Only 60/100 and 27.9/100 @entity0 were azoospermic by 12 weeks and 20 ejaculations, respectively. These end points are the commonly recommended waiting periods when semen analysis is unavailable. Of the 217 @entity0 36 (16.6%) did not achieve @entity1 by 24 weeks, of whom 25 (11.5% of all @entity0 ) were considered to have vasectomy failure. CONCLUSIONS: Our results suggest that it is not possible to develop guidelines for clearance based only on the time or number of ejaculations when ligation and excision are performed. In addition, of the methods for vas occlusion during vasectomy ligation and excision may not provide the best success rates.

title: A prospective study of time and number of ejaculations to XXXX after vasectomy by ligation and excision.

answer: @entity1


abstract: BACKGROUND: Due to recent lifestyle changes, the worldwide incidence of @entity2 is on the increase. This study focuses on the clinical and pathological profile of @entity2 of the oropharynx as seen in a north-central Nigerian teaching hospital. METHODS: This is a descriptive retrospective analysis of the clinical and pathological profile of this disease. RESULTS: Six @entity0 aged between 37 years and 78 years had @entity2 . There were 5 (83.3%) males and 1 (16.7%) female. All @entity0 presented with cervical @entity1 , @entity4 , odynophagia and muffled voice with @entity6 and visible masses filling up the oral cavity and oropharynx. Four (66.7%) @entity0 presented with @entity5 and 3 (50%) with @entity9 and @entity8 . Three (50%) @entity0 had histologic diagnosis of @entity7 (centroblastic), 1 had lymphoepithelioma and 2 had @entity3 . Two (33.3%) @entity0 died during treatment, 2 (33.30%) defaulted and 1 (16.7%) is being followed up for 5 years and is @entity2 free. CONCLUSION: @entity2 has a poor prognosis in the tropics due to late presentation. Proper health education aimed at early detection and treatment in our environment is required.

title: Clinicopathological profile of XXXX of the oropharynx: a case series.

answer: @entity2


abstract: OBJECTIVE: To outline methods for deriving and validating @entity1 ( @entity1 ) antimicrobial utilization (AU) measures from computerized data and to describe programming problems that emerged. DESIGN: Retrospective evaluation of computerized pharmacy and administrative data. SETTING: ICUs from 4 academic medical centers over 36 months. INTERVENTIONS: Investigators separately developed and validated programming code to report AU measures in selected ICUs. Use of antibacterial and antifungal drugs for systemic administration was categorized and expressed as antimicrobial-days (each day that each antimicrobial drug was given to each @entity0 ) and @entity0 -days receiving antimicrobials (each day that any antimicrobial drug was given to each @entity0 ). Monthly rates were compiled and analyzed centrally, with @entity1 @entity0 -days as the denominator. Results were validated against data collected from manual review of medical records. Frequent discussion among investigators aided identification and correction of programming problems. RESULTS: AU data were successfully programmed though a reiterative process of computer code revision. After identifying and resolving major programming errors, comparison of computerized @entity0 -level data with data collected by manual review of medical records revealed discrepancies in antimicrobial-days and @entity0 -days receiving antimicrobials that ranged from less than 1% to 17.7%. The hospital from which numerator data were derived from electronic records of medication administration had the least discrepant results. CONCLUSIONS: Computerized AU measures can be derived feasibly, but threats to validity must be sought out and corrected. The magnitude of discrepancies between computerized AU data and a gold standard based on manual review of medical records varies, with electronic records of medication administration providing maximal accuracy.

title: Deriving measures of XXXX antimicrobial use from computerized pharmacy data: methods, validation, and overcoming barriers.

answer: @entity1


abstract: Thermotherapy combined with tegafur ( @entity5 ) and @entity3 was performed in 13 @entity0 with @entity2 . The thermotherapy was performed using a closed circulation type of thermotherapeutic apparatus manufactured for this experiment, by way of a 3-way catheter. The flow rate of the perfusate was 150 ml/min at a constant temperature of 43 degrees C. The temperature was monitored at the inlet and outlet catheter of the urethral meatus. The thermotherapy was performed for a 6-hour period once a week. A tegafur 3000-mg suppository was given 2 hours before the thermotherapy, and @entity3 was added to the perfusate at the time of thermotherapy. No anesthesia was used. @entity1 was observed in 1 case. The concentrations of tegafur in the serum, @entity1 and bladder wall were measured simultaneously. The levels obtained at two hours after rectal administration of the tegafur 3000-mg suppository were 19.420 mcg/ml for @entity5 and 0.025 mcg/ml for @entity4 in the serum, 13.170 mcg/g for @entity5 and 0.140 mcg/g for @entity4 in the @entity2 , and 20.447 mcg/g for @entity5 and 0.252 mcg/g for @entity4 in the bladder wall. Eruption was observed in 1 case. No other side effects were noted.

title: [Thermotherapy for @entity2 in combination with tegafur suppository and XXXX --concentrations of tegafur in the serum and tissues in @entity2 ].

answer: @entity3


abstract: Thermotherapy combined with tegafur ( @entity5 ) and @entity3 was performed in 13 @entity0 with @entity2 . The thermotherapy was performed using a closed circulation type of thermotherapeutic apparatus manufactured for this experiment, by way of a 3-way catheter. The flow rate of the perfusate was 150 ml/min at a constant temperature of 43 degrees C. The temperature was monitored at the inlet and outlet catheter of the urethral meatus. The thermotherapy was performed for a 6-hour period once a week. A tegafur 3000-mg suppository was given 2 hours before the thermotherapy, and @entity3 was added to the perfusate at the time of thermotherapy. No anesthesia was used. @entity1 was observed in 1 case. The concentrations of tegafur in the serum, @entity1 and bladder wall were measured simultaneously. The levels obtained at two hours after rectal administration of the tegafur 3000-mg suppository were 19.420 mcg/ml for @entity5 and 0.025 mcg/ml for @entity4 in the serum, 13.170 mcg/g for @entity5 and 0.140 mcg/g for @entity4 in the @entity2 , and 20.447 mcg/g for @entity5 and 0.252 mcg/g for @entity4 in the bladder wall. Eruption was observed in 1 case. No other side effects were noted.

title: [Thermotherapy for XXXX in combination with tegafur suppository and @entity3 --concentrations of tegafur in the serum and tissues in @entity2 ].

answer: @entity2


abstract: Thermotherapy combined with tegafur ( @entity5 ) and @entity3 was performed in 13 @entity0 with @entity2 . The thermotherapy was performed using a closed circulation type of thermotherapeutic apparatus manufactured for this experiment, by way of a 3-way catheter. The flow rate of the perfusate was 150 ml/min at a constant temperature of 43 degrees C. The temperature was monitored at the inlet and outlet catheter of the urethral meatus. The thermotherapy was performed for a 6-hour period once a week. A tegafur 3000-mg suppository was given 2 hours before the thermotherapy, and @entity3 was added to the perfusate at the time of thermotherapy. No anesthesia was used. @entity1 was observed in 1 case. The concentrations of tegafur in the serum, @entity1 and bladder wall were measured simultaneously. The levels obtained at two hours after rectal administration of the tegafur 3000-mg suppository were 19.420 mcg/ml for @entity5 and 0.025 mcg/ml for @entity4 in the serum, 13.170 mcg/g for @entity5 and 0.140 mcg/g for @entity4 in the @entity2 , and 20.447 mcg/g for @entity5 and 0.252 mcg/g for @entity4 in the bladder wall. Eruption was observed in 1 case. No other side effects were noted.

title: [Thermotherapy for @entity2 in combination with tegafur suppository and @entity3 --concentrations of tegafur in the serum and tissues in XXXX ].

answer: @entity2


abstract: BACKGROUND: A number of studies have examined the effects of prenatal exposure to stress on birth outcomes but few have specifically focused on @entity3 . In the present protocol, we aim to examine if work characterised by high demands and low control, during pregnancy, is associated with the risk of giving birth to a @entity0 born preterm or small for gestational age. METHODS AND DESIGN: We will use the Danish National Birth Cohort where 100.000 @entity0 are included at baseline. In the present study 49,340 pregnancies will be included. Multinomial logistic regression will be applied to estimate odds ratios for the outcomes: preterm; full term but small for gestational age; full term but large for gestational age, as a function of job-strain (high strain, active and passive versus low strain). In the analysis we control for maternal age, Body Mass Index, parity, exercise, smoking, @entity2 use, coffee consumption, type of work (manual versus non-manual), @entity1 and parents' heights as well as gestational age at interview. DISCUSSION: The prospective nature of the design and the high number of @entity0 strengthen the study. The large statistical power allows for interpretable results regardless of whether or not the hypotheses are confirmed. This is, however, not a controlled study since all kinds of 'natural' interventions takes place throughout pregnancy (e.g. work absence, medical treatment and job-redesign). The analysis will be performed from a public health perspective. From this perspective, we are not primarily interested in the effect of job strain per se but if there is residual effect of job strain after naturally occurring preventive measures have been taken.

title: Testing the association between XXXX and adverse birth outcomes--design and methods.

answer: @entity3


abstract: OBJECTIVE: To present our experience in the treatment of severe @entity2 of the external urinary meatus in male @entity0 and adults with @entity4 . MATERIALS AND METHODS: A total of 21 @entity0 were operated on in a 5-year period, using the meatoplasty technique of Malone. Mean @entity0 age was 41.7 years (range 7-75). Mean postoperative follow-up was 40.8 months (range 6-54). The surgical procedure consisted in making a small ventral incision of the urethral meatus with an extensive dorsal meatotomy, correcting the esthetic defect of the gland with an inverted V-shaped relieving incision. The postoperative evaluation was performed in every @entity0 by written questionnaire informing about the functional and cosmetic results of the surgical technique. RESULTS: No @entity1 or recurrences of the @entity3 were recorded. A total of 18 @entity0 (85.7%) replied to the post-surgical questionnaire. All were very satisfied with the functional result. Fifteen (83.3%) were also very satisfied with the cosmetic results of the technique. CONCLUSION: The meatoplasty of Malone is a good alternative for the treatment of @entity3 . It is an easy and rapid-to-perform technique. It avoids creating a hypospadiac meatus and achieves good postoperative results.

title: [Treatment of XXXX due to @entity4 . Long term results using the meatoplasty of Malone].

answer: @entity3


abstract: OBJECTIVE: To present our experience in the treatment of severe @entity2 of the external urinary meatus in male @entity0 and adults with @entity4 . MATERIALS AND METHODS: A total of 21 @entity0 were operated on in a 5-year period, using the meatoplasty technique of Malone. Mean @entity0 age was 41.7 years (range 7-75). Mean postoperative follow-up was 40.8 months (range 6-54). The surgical procedure consisted in making a small ventral incision of the urethral meatus with an extensive dorsal meatotomy, correcting the esthetic defect of the gland with an inverted V-shaped relieving incision. The postoperative evaluation was performed in every @entity0 by written questionnaire informing about the functional and cosmetic results of the surgical technique. RESULTS: No @entity1 or recurrences of the @entity3 were recorded. A total of 18 @entity0 (85.7%) replied to the post-surgical questionnaire. All were very satisfied with the functional result. Fifteen (83.3%) were also very satisfied with the cosmetic results of the technique. CONCLUSION: The meatoplasty of Malone is a good alternative for the treatment of @entity3 . It is an easy and rapid-to-perform technique. It avoids creating a hypospadiac meatus and achieves good postoperative results.

title: [Treatment of @entity3 due to XXXX . Long term results using the meatoplasty of Malone].

answer: @entity4


abstract: Lysoplasmalogenase (EC 3.3.2.2 and EC 3.3.2.5) is an enzyme that catalyzes hydrolytic cleavage of the @entity7 bond of lysoplasmalogen, forming @entity9 and @entity8 or @entity6 and is specific for the sn-2-deacylated form of plasmalogen. Here we report the purification, characterization, identification, and cloning of lysoplasmalogenase. @entity1 liver microsomal lysoplasmalogenase was solubilized with @entity4 and purified 500-fold to near homogeneity using four chromatography steps. The purified enzyme has apparent K(m) values of    50  m for both @entity5 and @entity5 and apparent V(m) values of 24.5 and 17.5  mol/min/mg protein for the two substrates, respectively. The pH optimum was 7.0. Lysoplasmalogenase was competitively inhibited by @entity3 (K(i)    20  m). The predominant band on a gel at    19 kDa was subjected to trypsinolysis, and the peptides were identified by mass spectrometry as @entity10 , a protein of unknown function. Transient transfection of @entity0 embryonic kidney (HEK) 293T cells showed that @entity10 cDNA yielded lysoplasmalogenase activity, and Western blot analyses confirmed the synthesis of @entity10 protein. The protein was localized in the membrane fractions. The @entity10 gene was also transformed into @entity2 , and its expression was verified by Western blot and activity analyses. @entity10 is a hydrophobic transmembrane protein of the YhhN family. Northern blot analyses demonstrated that liver expressed the highest level of @entity10 , which agreed with tissue distribution of activity. Overexpression of @entity10 in HEK 293T cells resulted in decreased levels of plasmalogens, suggesting that the enzyme may be important in regulating plasmalogen levels in animal cells.

title: Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the XXXX bond of lysoplasmalogen.

answer: @entity7


abstract: @entity10 of the liver has been a controversial entity, in particular, regarding differentiation from @entity8 of the bile duct. In this study, we compared the characteristics of hepatic mucinous @entity2 (n=29) to those of cyst-forming @entity8 of the bile duct (n=12). Radiological or macroscopic appearance, histological grade of @entity1 , and postoperative clinical course were recorded. Immunohistochemistry for biliary or gastrointestinal markers was performed to characterize cell phenotypes. The @entity0 with hepatic mucinous @entity1 were all female and ranged in age from 21 to 67 years, which was significantly younger than that in the @entity0 with @entity5 . Eighteen mucinous @entity1 (76%) were located in the left lobe, with 13 (54%) in segment IV. @entity10 were significantly larger than @entity8 (median diameter: 110 vs 50 mm, P=0.008). In contrast to @entity8 that were all histologically malignant, 26 mucinous @entity1 (90%) were @entity4 , 2 (7%) were borderline malignant, and 1 (3%) was a @entity3 in situ. Benign mucinous @entity9 had the pure biliary immunophenotype, whereas gastrointestinal markers including @entity6 and @entity7 core proteins 2, 5AC, and 6 were more frequently expressed in borderline or malignant mucinous @entity1 and @entity5 . There was no mortality in the @entity0 with mucinous @entity1 , whereas one @entity0 with @entity8 died of @entity1 . In conclusion, hepatic mucinous @entity1 and @entity5 have different clinicopathological characteristics as evidenced by differences in the age and gender of @entity0 , macroscopic appearance, immunophenotypes, and grades of @entity1 .

title: Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with XXXX of the bile duct.

answer: @entity8


abstract: The precipitation and growth of @entity2 on @entity0 in physiological @entity1 solution were investigated. @entity2 was found to form at bottom of scratches on the surface which may be the less effective sites for diffusion or the favorable sites for heterogeneous nucleation. Patches of @entity3 expanded laterally on the substrate until a continuous film formed. The ionic transport path through this newly formed continuous film was via spaces between @entity2 patches. As the film grew, the spaces between @entity2 patches closed and ion transport was primarily via micro-channels running through @entity2 patches. The decrease of @entity2 layer conductivity during film growth were attributed to the clogging of micro-channels or decrease in charge carrier concentration inside the micro-channels. Under thin @entity2 layer, i.e. on the order of a micrometer, the dissolution of @entity0 substrate was under mixed activation-Ohmic control. Under thick @entity2 layer, i.e. on the order of tens of micrometers, the dissolution of @entity0 substrate was mediated by the Ohmic resistance of @entity2 layer.

title: The Effect of XXXX Formation on the Kinetics of @entity0 Dissolution in Chloride Solution.

answer: @entity3


abstract: The precipitation and growth of @entity2 on @entity0 in physiological @entity1 solution were investigated. @entity2 was found to form at bottom of scratches on the surface which may be the less effective sites for diffusion or the favorable sites for heterogeneous nucleation. Patches of @entity3 expanded laterally on the substrate until a continuous film formed. The ionic transport path through this newly formed continuous film was via spaces between @entity2 patches. As the film grew, the spaces between @entity2 patches closed and ion transport was primarily via micro-channels running through @entity2 patches. The decrease of @entity2 layer conductivity during film growth were attributed to the clogging of micro-channels or decrease in charge carrier concentration inside the micro-channels. Under thin @entity2 layer, i.e. on the order of a micrometer, the dissolution of @entity0 substrate was under mixed activation-Ohmic control. Under thick @entity2 layer, i.e. on the order of tens of micrometers, the dissolution of @entity0 substrate was mediated by the Ohmic resistance of @entity2 layer.

title: The Effect of @entity3 Formation on the Kinetics of XXXX Dissolution in Chloride Solution.

answer: @entity0


abstract: BACKGROUND: Nurses working in @entity1 ( @entity1 ) are in the most danger of workplace violence (WPV) because of the critical nature of the wards. AIMS: This study aimed to find the frequency and nature of physical and verbal WPV against Iranian nurses working in @entity1 . METHODS: A cross-sectional study was carried out using consensus sampling of 196 bachelor's degree nurses working in 11 @entity1 of teaching hospitals in Tehran, Iran. The data were collected through the adapted version of a self-administered questionnaire developed by the International Labor Office/International Council of Nurses/World Health Organization/Public Services International on WPV in the health sector. The gathered data were analysed using descriptive and inferential statistics. RESULTS: The @entity0 were mostly (89.1%) female and their work experiences (63.2%) in nursing were between 1 and 5 years; 19.7% of the nurses had faced physical violence. All of the physical violence incidents were without-weapon; 91.6% of the @entity0 experienced @entity2 during the past year. @entity0 ' relatives were the most common source of violence. Dissatisfaction was reported on the way the incidents were handled. CONCLUSION: It is believed that finding the pattern and nature of WPV is the first step to develop suitable strategies to deal with the issue. Establishing WPV management teams and enacting appropriate laws can improve workplace safety for nurses and @entity0 ' care quality.

title: Workplace violence against Iranian nurses working in XXXX .

answer: @entity1


abstract: In Mauritius, the maternal mortality rate (MMR) was 21 per 100000 live births for the year 2001 and this is comparable with figures from developed countries. There has been poor documentation in the area of @entity1 disorders of pregnancy until recently in the island. Consequently, we analysed data from the Ministry of Health. @entity1 of pregnancy occurred in 6.7% gravidas in 2001. Out of four maternal @entity2 recorded in 2001, two occurred due to severe @entity5 . In the second part of our study, we scrutinised also the obstetric notes and interviewed 862 hospitalised @entity0 from four main hospitals of the island between 1995 and 1997. The majority of @entity0 were affected by non-proteinuric @entity1 (70%), followed by @entity4 (24%) and chronic @entity1 (6%). Preeclamptic primi and multigravidas developed the condition earlier and also gave birth to growth-retarded babies. Highly significant results supported the relationship between @entity3 and @entity4 in different parities, irrespective of the length of exposure of the baby in utero. Preeclampsia affects both Indo-Mauritians and Creoles to the same extent, but the latter are much more prone to gestational @entity1 . In addition, @entity1 disorders of pregnancy are more a problem of multigravid @entity0 in Creoles while they are more classically a condition of primigravidae in Indians.

title: Epidemiology of XXXX in Mauritius island.

answer: @entity4


abstract: Transplant-transmitted malignances are rare but devastating events. @entity4 are the least common among reported donor-derived @entity1 . We report a case of donor-transmitted @entity3 , a @entity6 , in a two-yr-old male recipient, who presented with a rapidly growing mass in the right mandible, four months after multiple visceral organ transplantation. The recipient had liver, pancreas, and small bowel transplants because of end-stage @entity5 and @entity2 , which was secondary to large bowel resection for management of @entity7 complicated by intestinal volvulus. The donor autopsy results became available seven wk after transplantation, which found a @entity3 with meningeal spread. Evaluation of eyes, adrenal glands, bone marrow, and other organs did not identify @entity0 outside the CNS. A biopsy of the recipient's right mandibular mass revealed a malignant small round blue cell @entity1 with the immunohistochemistry profile of a @entity6 . Staging evaluation revealed the @entity1 in the right mandible with bone marrow involvement. Further investigation showed that @entity1 and donor's @entity3 shared the same immunophenotype and HLA type, suggesting the @entity1 is a donor-transmitted @entity3 . This is the first case report of donor-transmitted @entity3 post-organ transplant.

title: Donor transmission of XXXX in a two-yr-old male recipient of a multivisceral transplant: a case report.

answer: @entity3


abstract: OBJECTIVES: To analyze @entity2 ( @entity2 ) presentations after @entity6 -accelerated detoxification. METHODS: This was a retrospective cohort analysis of @entity0 presentations to Sir Charles Gairdner Hospital Emergency Department over a six-month period (November 2000 to April 2001). RESULTS: During the six-month study period, 42 @entity0 presented to the @entity2 after @entity6 -accelerated detoxification. This represented 7% of @entity0 treated at a single clinic over the same period. Presentation occurred within 24 hours in 40% of cases and within 48 hours in 74%. Clinical features on presentation included @entity3 ( @entity4 , 60%; @entity5 , 55%; @entity1 , 45%), central nervous system [CNS] symptoms (excessive drowsiness, 55%; @entity8 requiring sedation, 50%), and respiratory symptoms ( @entity9 , 33%; respiratory difficulties, 19%). Gastrointestinal symptoms were managed adequately with supportive therapy in most cases (intravenous fluids; antiemetics). Agitation sometimes required large doses of intravenous @entity7 (up to 730 mg in 44 hours), one-to-one nursing, and security staff. Two of 14 @entity0 presenting with predominantly CNS disturbance required intubation (14%). Mean in-hospital stay for all @entity0 was 18 hours (range 1 to 92 hours). CONCLUSIONS: A few @entity0 undergoing outpatient @entity6 -accelerated detoxification during a six-month period subsequently required @entity2 management. The clinical features encountered in this group of @entity0 can be subdivided into GI or CNS predominance, with different management strategies. Most presentations can be managed in the @entity2 or an associated observation ward, but departmental resources must be available for one-to-one nursing and security personnel. @entity0 presenting with @entity8 should be sedated with @entity7 ; large doses may be required. Close monitoring of respiratory function is mandatory, and advanced airway management may be required.

title: Emergency department presentations of XXXX -accelerated detoxification.

answer: @entity6


abstract: OBJECTIVES: To compare the characteristics of sexual assault in pubertal @entity0 (<18 years old) and adults in a community-based population of @entity0 presenting to an urban @entity2 . METHODS: This case-series analysis evaluated consecutive female @entity0 presenting to a @entity2 during a three-year study period. The clinic is associated with a university-affiliated emergency medicine residency program and is staffed by forensic nurses trained to perform medicolegal examinations using colposcopy with nuclear staining. @entity0 demographics, assault characteristics, and injury patterns were recorded using a standardized classification system. Data from the two @entity0 groups (adolescents vs. @entity0 > or =18 years of age) were analyzed using chi-square test and t-test. RESULTS: A total of 766 cases were identified: 43% of the victims were 13 to 17 years old (mean 15.0 years old), and 57% were older than 17 years old (mean 30.8 years old). Adolescents were more likely to be assaulted by an acquaintance or relative (84% vs. 50%, p < 0.001) and to delay medical evaluation (17 hours vs. 12 hours, p < 0.001) than were older @entity0 . Adolescent sexual assault was less likely to involve weapons or physical coercion (29% versus 57%, p < 0.001) and was associated with fewer @entity1 (33% vs. 55%, p < 0.001). Adolescents had a greater frequency of @entity1 (83% vs. 64%, p < 0.001), however, compared with older @entity0 . Common sites of injury in adolescents were posterior, including the fossa navicularis, hymen, fourchette, and labia minora. The injuries showed consistent topologic features, varying with the site and nature of tissue. Adult victims of sexual assault had a less consistent pattern of @entity1 with fewer @entity1 , greater @entity1 , and widespread erythema. CONCLUSIONS: Of @entity0 presenting to an urban @entity2 , 43% were adolescents. The epidemiology of @entity1 in this age group are unique and may pose special challenges to emergency health care providers.

title: Comparative analysis of adult versus adolescent sexual assault: epidemiology and patterns of XXXX .

answer: @entity1


abstract: BACKGROUND: Because of the quick development and widespread use of mobile phones, and their vast effect on communication and interactions, it is important to study possible negative health effects of mobile phone exposure. The overall aim of this study was to investigate whether there are associations between psychosocial aspects of mobile phone use and mental health symptoms in a prospective cohort of young adults. METHODS: The study group consisted of young adults 20-24 years old (n = 4156), who responded to a questionnaire at baseline and 1-year follow-up. Mobile phone exposure variables included frequency of use, but also more qualitative variables: demands on availability, perceived stressfulness of accessibility, being awakened at night by the mobile phone, and personal overuse of the mobile phone. Mental health outcomes included current stress, @entity1 , and symptoms of @entity2 . Prevalence ratios (PRs) were calculated for cross-sectional and prospective associations between exposure variables and mental health outcomes for @entity0 and @entity0 separately. RESULTS: There were cross-sectional associations between high compared to low mobile phone use and stress, @entity1 , and symptoms of @entity2 for the @entity0 and @entity0 . When excluding respondents reporting mental health symptoms at baseline, high mobile phone use was associated with @entity1 and symptoms of @entity2 for the @entity0 and symptoms of @entity2 for the @entity0 at 1-year follow-up. All qualitative variables had cross-sectional associations with mental health outcomes. In prospective analysis, overuse was associated with stress and @entity1 for @entity0 , and high accessibility stress was associated with stress, @entity1 , and symptoms of @entity2 for both @entity0 and @entity0 . CONCLUSIONS: High frequency of mobile phone use at baseline was a risk factor for mental health outcomes at 1-year follow-up among the young adults. The risk for reporting mental health symptoms at follow-up was greatest among those who had perceived accessibility via mobile phones to be stressful. Public health prevention strategies focusing on attitudes could include information and advice, helping young adults to set limits for their own and others' accessibility.

title: Mobile phone use and stress, @entity1 , and symptoms of XXXX among young adults--a prospective cohort study.

answer: @entity2


abstract: BACKGROUND: Because of the quick development and widespread use of mobile phones, and their vast effect on communication and interactions, it is important to study possible negative health effects of mobile phone exposure. The overall aim of this study was to investigate whether there are associations between psychosocial aspects of mobile phone use and mental health symptoms in a prospective cohort of young adults. METHODS: The study group consisted of young adults 20-24 years old (n = 4156), who responded to a questionnaire at baseline and 1-year follow-up. Mobile phone exposure variables included frequency of use, but also more qualitative variables: demands on availability, perceived stressfulness of accessibility, being awakened at night by the mobile phone, and personal overuse of the mobile phone. Mental health outcomes included current stress, @entity1 , and symptoms of @entity2 . Prevalence ratios (PRs) were calculated for cross-sectional and prospective associations between exposure variables and mental health outcomes for @entity0 and @entity0 separately. RESULTS: There were cross-sectional associations between high compared to low mobile phone use and stress, @entity1 , and symptoms of @entity2 for the @entity0 and @entity0 . When excluding respondents reporting mental health symptoms at baseline, high mobile phone use was associated with @entity1 and symptoms of @entity2 for the @entity0 and symptoms of @entity2 for the @entity0 at 1-year follow-up. All qualitative variables had cross-sectional associations with mental health outcomes. In prospective analysis, overuse was associated with stress and @entity1 for @entity0 , and high accessibility stress was associated with stress, @entity1 , and symptoms of @entity2 for both @entity0 and @entity0 . CONCLUSIONS: High frequency of mobile phone use at baseline was a risk factor for mental health outcomes at 1-year follow-up among the young adults. The risk for reporting mental health symptoms at follow-up was greatest among those who had perceived accessibility via mobile phones to be stressful. Public health prevention strategies focusing on attitudes could include information and advice, helping young adults to set limits for their own and others' accessibility.

title: Mobile phone use and stress, XXXX , and symptoms of @entity2 among young adults--a prospective cohort study.

answer: @entity1


abstract: BACKGROUND: Cyclosporin A (CsA), a potent immunosuppressive agent, can be nephrotoxic. Because clinical studies have suggested that the intrarenal renin-angiotensin system may be involved in the mechanism responsible for CsA nephrotoxicity, we have analysed the effects of CsA on angiotensin II ( @entity2 ) receptors in medullary thick ascending limb (mTAL) cells known to be sensitive to the action of CsA. METHODS: Experiments were carried out on subcultured @entity0 mTAL cells. The expression of mRNA of @entity2 subtype 1 and 2 ( @entity1 (1) and @entity1 (2)) receptors was investigated using reverse transcription-polymerase chain reaction (RT-PCR). [(3)H] @entity2 was used for radioligand and binding studies. Fluorimetric recordings using the fluorescent dye fura-2/AM were performed to determine the effect of CsA on the intracellular calcium ([Ca(2+)]i) content of untreated and @entity3 II-treated mTAL cells. RESULTS: Subcultured mTAL cells expressed @entity1 (1) and @entity1 (2) @entity2 receptor mRNAs, and binding studies revealed that the @entity1 (1) receptors were the predominant @entity2 receptor subtype ( approximately 90%) in mTAL cells. CsA (100 ng/ml, 24 h) increased (1.7-fold) the number of @entity2 receptors (untreated, 315.8; +CsA, 543.6 fmol/mg protein) without altering the K(D) (untreated, 7.16; +CsA, 7.06 nM). CsA also significantly increased the level of [Ca(2+)]i measured in cultured mTAL cells both in the basal state (-CSA, 72.2; +CsA, 93.4 nM/10(6) cells) and in the presence of @entity2 (-CSA, 97.8; +CsA, 206.3 nM/10(6) cells). CONCLUSIONS: These findings suggest that the increase in @entity2 @entity1 (1) receptors and [Ca(2+)]i caused by CsA may be involved in the mechanism(s) responsible for CsA nephrotoxicity.

title: Cyclosporin increases the density of angiotensin II subtype 1 (AT1) receptors in XXXX medullary thick ascending limb cells.

answer: @entity0


abstract: BACKGROUND: This study examined associations of @entity1 and @entity2 with cognitive processes, @entity3 achievement, and behavior, independent of demographic factors, at the baseline of an exercise trial. METHODS: Overweight, sedentary but otherwise healthy 7-11 year olds (N=170) participated in a study of health, cognition and achievement in the Augusta, GA area from 2003-2006. @entity0 underwent evaluations of @entity2 and @entity1 , psychological assessments of cognition and @entity3 achievement, and behavior ratings by parents and teachers. Partial correlations examined associations of @entity1 and @entity2 with cognitive and achievement scores and behavior ratings, controlling for demographic factors. RESULTS: Fitness was associated with better cognition, achievement and behavior, and @entity2 with worse scores. Specifically, executive function, mathematics and reading achievement, and parent ratings of @entity0 behavior were related to @entity1 and @entity2 . Teacher ratings were related to @entity1 . CONCLUSION: These results extend prior studies by providing reliable, standardized measures of cognitive processes, achievement, and behavior in relation to detailed measures of @entity1 and @entity2 . However, cross-sectional associations do not necessarily indicate that improving one factor, such as @entity2 or @entity1 , will result in improvements in factors that were associated with it. Thus, randomized clinical trials are necessary to determine the effects of interventions.

title: Fitness, @entity2 , cognition, behavior, and XXXX achievement among overweight @entity0 : do cross-sectional associations correspond to exercise trial outcomes?

answer: @entity3


abstract: BACKGROUND: This study examined associations of @entity1 and @entity2 with cognitive processes, @entity3 achievement, and behavior, independent of demographic factors, at the baseline of an exercise trial. METHODS: Overweight, sedentary but otherwise healthy 7-11 year olds (N=170) participated in a study of health, cognition and achievement in the Augusta, GA area from 2003-2006. @entity0 underwent evaluations of @entity2 and @entity1 , psychological assessments of cognition and @entity3 achievement, and behavior ratings by parents and teachers. Partial correlations examined associations of @entity1 and @entity2 with cognitive and achievement scores and behavior ratings, controlling for demographic factors. RESULTS: Fitness was associated with better cognition, achievement and behavior, and @entity2 with worse scores. Specifically, executive function, mathematics and reading achievement, and parent ratings of @entity0 behavior were related to @entity1 and @entity2 . Teacher ratings were related to @entity1 . CONCLUSION: These results extend prior studies by providing reliable, standardized measures of cognitive processes, achievement, and behavior in relation to detailed measures of @entity1 and @entity2 . However, cross-sectional associations do not necessarily indicate that improving one factor, such as @entity2 or @entity1 , will result in improvements in factors that were associated with it. Thus, randomized clinical trials are necessary to determine the effects of interventions.

title: Fitness, XXXX , cognition, behavior, and @entity3 achievement among overweight @entity0 : do cross-sectional associations correspond to exercise trial outcomes?

answer: @entity2


abstract: BACKGROUND: This study examined associations of @entity1 and @entity2 with cognitive processes, @entity3 achievement, and behavior, independent of demographic factors, at the baseline of an exercise trial. METHODS: Overweight, sedentary but otherwise healthy 7-11 year olds (N=170) participated in a study of health, cognition and achievement in the Augusta, GA area from 2003-2006. @entity0 underwent evaluations of @entity2 and @entity1 , psychological assessments of cognition and @entity3 achievement, and behavior ratings by parents and teachers. Partial correlations examined associations of @entity1 and @entity2 with cognitive and achievement scores and behavior ratings, controlling for demographic factors. RESULTS: Fitness was associated with better cognition, achievement and behavior, and @entity2 with worse scores. Specifically, executive function, mathematics and reading achievement, and parent ratings of @entity0 behavior were related to @entity1 and @entity2 . Teacher ratings were related to @entity1 . CONCLUSION: These results extend prior studies by providing reliable, standardized measures of cognitive processes, achievement, and behavior in relation to detailed measures of @entity1 and @entity2 . However, cross-sectional associations do not necessarily indicate that improving one factor, such as @entity2 or @entity1 , will result in improvements in factors that were associated with it. Thus, randomized clinical trials are necessary to determine the effects of interventions.

title: Fitness, @entity2 , cognition, behavior, and @entity3 achievement among overweight XXXX : do cross-sectional associations correspond to exercise trial outcomes?

answer: @entity0


abstract: OBJECTIVE: To describe results of treating @entity2 of the head and neck with a Mohs surgical technique in which @entity1 margins were evaluated with inverted horizontal paraffin sections to identify the margin of resection necessary to achieve @entity1 -free borders. STUDY DESIGN: Retrospective case study of nine @entity0 . METHODS: In each case, Mohs surgery using inverted horizontal frozen-section analysis was continued until @entity1 -free margins were achieved. The @entity1 -free specimens collected during this procedure were immediately reprocessed by using inverted horizontal paraffin sectioning, and the histological results of the two techniques were compared. To identify the margins of resection needed to achieve @entity1 -free margins, preoperative lesion size was compared with postoperative defect size. RESULTS: Paraffin section analysis showed persistent @entity1 in seven of the nine @entity0 in whom the frozen-section technique was used to clear the @entity1 . @entity1 -free margins were achieved in all @entity0 by using one additional excision. The @entity1 had spread extensively beyond clinical margins and required a mean minimum margin of 3.7 cm around the gross area of @entity1 (margin range, 2.5-6.0 cm). @entity0 treated by this technique showed no local, regional, or distant recurrence at follow-up performed at a mean time of 43 months postoperatively (range, 19-74 mo). CONCLUSIONS: @entity2 of the head and neck is a @entity1 that shows extensive infiltration beyond gross margins. Wide local excision with 2- to 3-cm margins results in an unacceptably high recurrence rate; larger excisional margins are necessary to remove all disease. Accurate margin identification achieved by using Mohs surgery with rush paraffin section analysis results in @entity1 removal and excellent control rates. This method should be preferred for treatment of @entity2 of the head and neck.

title: XXXX of the head and neck: treatment with Mohs surgery using inverted horizontal paraffin sections.

answer: @entity2


abstract: OBJECTIVE: To analyze clinical data and possible prognostic factors of @entity0 with @entity4 of the parotid gland. STUDY DESIGN: A retrospective study was made of 85 @entity0 with suspected @entity2 who were admitted to the Center of Head and Neck Oncology at Odense University Hospital (Odense, Denmark) from 1975 to 1994. METHODS: @entity0 records were retrospectively reviewed and tabulated for relevant clinical parameters. A complete revision of histological examination was performed by the same pathologist and the @entity2 were classified according to the 1991 international guidelines from the World Health Organization. @entity2 (6%) did not fulfill the criteria of @entity2 and were reclassified as benign. In another five cases the assumed primary @entity4 were found to be metastatic disease from @entity2 of the breast, prostate, skin, and lungs. Ten @entity0 (12%) were excluded from the analysis, leaving 75 individuals for the study. RESULTS: Twenty-four percent of @entity0 were classified as T1, 32% as T2, 15% as T3, and 28% as T4. One @entity0 (1%) was not classifiable (TX). Regional lymph node @entity1 were found in 17 cases (23%). Two of these were classified as N1 (3%), 2 as N2A (3%) and 13 as N2B (17%). Four @entity0 were registered as not classifiable (NX) (5%). No @entity0 were classified as N3. Distant @entity1 were found in four @entity0 (5%) (one @entity0 had bone and liver @entity1 and three @entity0 had lung @entity1 ). Five-year recurrence-free survival of the entire study group was 63%, disease-specific survival was 69%, and crude survival was 52%. In univariate analysis, @entity2 size, histological appearance, T status, stage, the presence of lymph node @entity1 , distant @entity1 , @entity3 had a significant influence on survival. CONCLUSIONS: A thorough histological revision is pivotal in retrospective @entity4 studies, and @entity2 size; histological appearance; T, N, and M status; stage; @entity5 ; and @entity3 from the face and/or neck seem to be significant prognostic indicators for @entity0 with primary @entity4 .

title: XXXX : impact of clinical factors on prognosis in a histologically revised series.

answer: @entity4


abstract: PURPOSE: To describe a new surgical technique in which @entity8 is diverted from the anterior chamber to the suprachoroidal space for the augmentation of uveoscleral outflow in the management of @entity3 . METHODS: Four @entity7 of four consecutive @entity0 were included in the study. Mean age of @entity0 was 54.7+/- 9.2 years. Preoperative diagnosis was @entity5 complicating @entity1 in three cases and chronic @entity6 in one case. Mean preoperative intraocular pressure of the @entity0 receiving two medications was 58.5 +/- 9.2 mm Hg. A modified Krupin eye valve with disk was implanted into the suprachoroidal space. The anterior tube part of the Seton device was placed into the anterior chamber through the long scleral tunnel for draining the @entity8 from the anterior chamber to the suprachoroidal space. RESULTS: The placement of modified Krupin eye valve with disk to the suprachoroidal space was achieved in all cases. While mean preoperative intraocular pressure was 58.5 +/- 9.2 mm Hg, it was 14.2 +/- 4.7 mm Hg at postoperative one week. It was 13.5 +/- 4.6 mm Hg and 15 +/- 4.9 mm Hg at one and three months respectively. At the last follow-up visit, mean intraocular pressure was 17.25 +/- 5.37 mm Hg ranging from 12 to 24 mm Hg. @entity4 was developed in one case and regressed in six weeks. Rubeosis irides regressed at third month in three cases. None of the eyes developed @entity2 , @entity4 , or phthisis bulbi. CONCLUSION: The drainage of @entity8 from the anterior chamber to the suprachoroidal space with the implantation of the @entity3 Seton device is effective in lowering intraocular pressure in @entity3 .

title: XXXX : a novel surgical technique.

answer: @entity3


abstract: Cartilage tissue engineering aims to replace damaged or diseased tissue with a functional regenerate that restores joint function. Scaffolds are used to deliver cells and facilitate tissue development, but they can also interfere with the structural assembly of the cartilage matrix. Biodegradable scaffolds have been proposed as a means to improve matrix deposition and the biomechanical properties of neocartilage. The challenge is designing scaffolds with appropriate degradation rates, ideally such that scaffold degradation is proportional to matrix deposition. In this study, we developed a bioresponsive hydrogel with cell-mediated degradation aligned to the chondrogenic differentiation of @entity0 mesenchymal stem cells (hMSCs). We identified @entity1 ( @entity1 ) as an enzyme with a temporal expression pattern that corresponded with cartilage development. By embedding @entity1 peptide substrates within a @entity2 backbone, we built @entity1 -sensitive hydrogels with distinct degradation rates. When @entity1 -sensitive scaffolds were compared with nondegradable scaffolds in vitro, photoencapsulated hMSCs produced neocartilage constructs with more extensive collagenous matrices, as demonstrated through immunohistochemistry and biochemical quantification of matrix molecules. Furthermore, these changes translated into an increased dynamic compressive modulus. This work presents a practical strategy for designing biomaterials uniquely tuned to individual biological processes.

title: A bioresponsive hydrogel tuned to chondrogenesis of XXXX mesenchymal stem cells.

answer: @entity0


abstract: PURPOSE: To determine the relationship between the postural changes of the intraocular pressure and the @entity1 in @entity0 with primary @entity2 . METHODS: Eleven normal subjects and 11 @entity0 with primary @entity2 were studied. Intraocular pressure was measured in both the sitting and the supine positions. Visual fields were measured with automated perimetry. RESULTS: When @entity0 moved from a sitting to supine position, the intraocular pressure increased by an average of 3.1 +/- 0.4 mm Hg (mean +/- SEM) in normal subjects and 4.0 +/- 0.2 mm Hg in @entity0 with primary @entity2 . There was a significant difference between the normal subjects and @entity0 with primary @entity2 (P = 0.049). Intraocular pressure increased by 4.4 +/- 0.3 mm Hg (P = 0.02) in the worse eye for mean deviation and 3.6 +/- 0.3 mm Hg (P = 0.38) in the better eye for mean deviation. There was no significant difference in intraocular pressure in the sitting position between both groups. CONCLUSIONS: The greatest difference in intraocular pressure between the sitting and supine positions was observed in the worse eye of @entity0 with primary @entity2 . This result suggests that damage to the optic nerve in primary @entity2 might occur when @entity0 are asleep in the supine position.

title: Relationship between postural change of the intraocular pressure and XXXX in primary @entity2 .

answer: @entity1


abstract: PURPOSE: To determine the relationship between the postural changes of the intraocular pressure and the @entity1 in @entity0 with primary @entity2 . METHODS: Eleven normal subjects and 11 @entity0 with primary @entity2 were studied. Intraocular pressure was measured in both the sitting and the supine positions. Visual fields were measured with automated perimetry. RESULTS: When @entity0 moved from a sitting to supine position, the intraocular pressure increased by an average of 3.1 +/- 0.4 mm Hg (mean +/- SEM) in normal subjects and 4.0 +/- 0.2 mm Hg in @entity0 with primary @entity2 . There was a significant difference between the normal subjects and @entity0 with primary @entity2 (P = 0.049). Intraocular pressure increased by 4.4 +/- 0.3 mm Hg (P = 0.02) in the worse eye for mean deviation and 3.6 +/- 0.3 mm Hg (P = 0.38) in the better eye for mean deviation. There was no significant difference in intraocular pressure in the sitting position between both groups. CONCLUSIONS: The greatest difference in intraocular pressure between the sitting and supine positions was observed in the worse eye of @entity0 with primary @entity2 . This result suggests that damage to the optic nerve in primary @entity2 might occur when @entity0 are asleep in the supine position.

title: Relationship between postural change of the intraocular pressure and @entity1 in primary XXXX .

answer: @entity2


abstract: BACKGROUND: Involvement of the Achilles tendon is frequent in @entity6 , but it is easily missed at clinical examination. OBJECTIVE: To seek evidence of @entity3 by means of sonography in psoriatic @entity0 and to correlate sonographic findings with clinical symptoms (tendon and soft-tissue swelling, @entity1 , and difficulty in walking). METHODS: Fifty-nine @entity0 with @entity5 (Psoriasis Area and Severity Index score, 3.7-34.7) and 50 healthy, aged-matched volunteers underwent clinical and sonographic evaluation of Achilles tendons and peritendinous structures. RESULTS: Eighteen (30.5%) of the 59 @entity0 had clinical symptoms of @entity4 . Thirty-five (59.3%) of the @entity0 had sonographic abnormalities. Of these, 13 @entity0 had clinically symptomatic abnormalities, and 11 had @entity6 . @entity2 was the most frequent sonographic finding (76.9%) among @entity0 with symptomatic conditions. Five @entity0 with symptoms did not have sonographic alterations. None of the controls had clinical or sonographic changes. CONCLUSIONS: In psoriatic @entity0 @entity3 cannot be excluded even when they are clinically absent.

title: XXXX in @entity5 : clinical and sonographic findings.

answer: @entity4