abstract: AIM: To investigate the ability of the preferential hyperacuity perimeter test to assess responsiveness to ranibizumab therapy for exudative @entity2 ( @entity2 ). METHODS: Fourteen consecutive @entity0 with newly diagnosed @entity4 underwent a preferential hyperacuity perimeter metamorphopsia test (main outcome measures) 1 h before (baseline) and 1 h, 1 day, 1 week and 1 month after one intravitreal injection of ranibizumab (0.05 ml/0.5 mg). Best corrected visual acuity (BCVA) and several spectral domain optical coherence tomography (OCT) parameters (secondary outcome measures) were compared with the metamorphopsia test. RESULTS: Fourteen eyes (14 @entity0 , 78% @entity0 , mean age 83    6.2 years) were included in the analysis. The mean preferential hyperacuity perimeter metamorphopsia test score improved significantly from 20.4    35 at baseline to 9.2    23 after the single ranibizumab injection (p < 0.05). The mean reduction in central macular thickness, maximal retinal thickness at the fovea, maximal height of subretinal fluid, maximal diameter of the largest retinal cyst and maximal height of @entity3 , as evaluated by spectral domain OCT, closely reflected the functional improvements as evaluated by preferential hyperacuity perimeter, showing a significant correlation with metamorphopsia changes (Spearman correlation 0.9, p < 0.05). Mean BCVA improved significantly from 20/80 to 20/60 (p < 0.05). A significant correlation was also found between the mean BCVA changes and the mean metamorphopsia changes (Spearman correlation 0.97, p < 0.05). The correlation coefficient between OCT measurements and preferential hyperacuity perimeter score within subjects was 0.51 (p < 0.05). CONCLUSION: The improvement in metamorphopsia test score after intravitreal ranibizumab injection, which correlated closely with improvement in several OCT parameters, suggests that the preferential hyperacuity perimeter test may be used to monitor the response to @entity1 ( @entity1 ) treatment in @entity0 with exudative @entity2 .

title: Preferential hyperacuity perimeter in assessing responsiveness to ranibizumab therapy for exudative XXXX .

answer: @entity2


abstract: @entity0 has caused severe outbreaks of @entity1 worldwide with thousands of recorded deaths annually. Molecular diagnosis for @entity1 has become increasingly important for rapid detection of @entity1 as the conventional methods are time-consuming and labour intensive. However, traditional PCR tests still require cold-chain transportation and storage as well as trained personnel to perform, which makes them user-unfriendly. The aim of this study was to develop a thermostabilized triplex PCR test for @entity1 which is in a ready-to-use form and requires no cold chain. The PCR test specifically detects both toxigenic and non-toxigenic strains of @entity0 based on the @entity1 toxin A (ctxA) and outer-membrane lipoprotein (lolB) genes. The thermostabilized triplex PCR also incorporates an internal amplification control that helps to check for PCR inhibitors in samples. PCR reagents and the specific primers were lyophilized into a pellet form in the presence of @entity2 , which acts as an enzyme stabilizer. The triplex PCR was validated with 174 bacteria-spiked stool specimens and was found to be 100% sensitive and specific. The stability of the thermostabilized PCR was evaluated using the Q10 method and it was found to be stable for approximately 7 months at 24   C. The limit of detection of the thermostabilized triplex PCR assay was 2 10(4) c.f.u. at the bacterial cell level and 100 pg DNA at the genomic DNA level, comparable to conventional PCR methods. In conclusion, a rapid thermostabilized triplex PCR assay was developed for detecting toxigenic and non-toxigenic @entity0 which requires minimal pipetting steps and is cold chain-free.

title: Development of a dry reagent-based triplex PCR for the detection of toxigenic and non-toxigenic XXXX .

answer: @entity0


abstract: INTRODUCTION: : Rotavirus vaccines were introduced into the funded Australian @entity2 ( @entity2 ) in July 2007. Due to purchasing arrangements, individual states and territories chose either a 2-dose RV1 (Rotarix, GSK) regimen or 3-dose RV5 (Rotateq, Merck/ @entity4 ) regimen. This allowed comparison of both vaccines in similar populations with high @entity0 vaccination coverage. METHODS: : Admission and rotavirus identification data from the major pediatric hospitals in 3 states (2 using RV5, 1 RV1), together with state-based hospitalization and vaccination data from Queensland (RV5) were analyzed for the years before, and up to 30 months following rotavirus vaccine introduction. Emergency encounters and short-stay unit admissions for @entity3 are also described. RESULTS: : Rotavirus vaccine coverage in Australia is high, with 87% of @entity0 receiving at least 1 dose. Hospital admissions for both @entity3 and nonrotavirus-coded @entity3 were reduced following vaccine introduction in all states, not only for the age group eligible for @entity2 rotavirus vaccination, but also for @entity0 born prior. RV5 vaccine efficacy in Queensland has been estimated at 89.3%. Marked reductions in @entity1 presentations and short-stay unit admissions have also been observed. CONCLUSIONS: : Early evidence from the @entity2 in Australia has demonstrated high rotavirus coverage with both RV1 and RV5. The introduction of both vaccines has been associated with a marked reduction in @entity3 admissions, supportive of both direct vaccine protection, as well as with indirect herd protection.

title: Reduction in rotavirus-associated acute XXXX following introduction of rotavirus vaccine into Australia's National Childhood vaccine schedule.

answer: @entity3


abstract: BACKGROUND: The molecular mechanisms underlying the growth of small size grafts and the remaining livers are poorly understood. MicroRNAs (miRNAs) negatively modulate expression of genes that are involved in cellular function and metabolism. The aim of this study is to identify critical miRNA species that modulate the growth of small grafts and the remaining livers after partial hepatectomy (PH). METHODS: Small size graft liver transplantation was performed in @entity0 . Liver tissue was harvested after transplant or PH for the determination of miRNA expression profile, and the data were confirmed by quantitative reverse-transcriptase polymerase chain reaction. The genes involved in cell cycle and proliferation were analyzed by quantitative reverse-transcriptase polymerase chain reaction and immunohistochemical staining. RESULTS: Compared with control liver, miR_122a, Let_7b, and @entity1 were reduced by more than 90% in 45% volume grafts. In the remaining livers after 50% PH, 30 miRNAs were down-regulated by more than 50%, and among them, miR_22a, @entity1 , @entity2 , Let_7f, and Let_7g were markedly decreased. A negative correlation existed between down-regulated miRNAs and highly up-regulated genes involved in cell cycle and proliferation in the remaining livers. Moreover, overexpression of @entity1 markedly down-regulated @entity3 protein levels and significantly decreased proliferation of HepG2 cells. CONCLUSION: Down-regulated miRNAs play a pivotal role in promoting the growth of small size grafts and the remaining livers. The negative correlation between down-regulated miRNAs and up-regulated genes suggests that these specific miRNAs participate in the modulation of a growth response in both living donors and small size graft recipients.

title: miRNA regulation of liver growth after 50% partial hepatectomy and small size grafts in XXXX .

answer: @entity0


abstract: Microalbuminuria is a common condition associated with increased incidence of cardiovascular events and mortality. @entity3 is associated with microalbuminuria, but studies linking @entity4 ( @entity4 ) and microalbuminuria are limited. Our objective was to determine the associations of @entity1 with @entity4 and @entity4 ( @entity4 ). We performed a cross-sectional study in the Framingham Multi-Detector Computed Tomography (MDCT) cohort (n = 3099, 48.2% @entity0 , mean age 53 years). @entity4 and @entity4 volumes were measured using computed tomography. Urinary albumin-to- @entity2 ratio (UACR) was calculated from spot urine samples. Microalbuminuria was defined as a UACR >25 mg/g in @entity0 or >17 mg/g in @entity0 . Overall, 7.9% (n = 244) of the sample had microalbuminuria. Among @entity0 , @entity4 ( @entity6 per s.d., P < 0.0001) and @entity4 (OR 1.37 per s.d., P = 0.0002) were associated with microalbuminuria in minimally adjusted models, which remained significant after multivariable adjustment ( @entity4 OR 1.34 per s.d., P = 0.001; @entity4 OR 1.28 per s.d., P = 0.005). Additionally, when considered jointly, @entity4 (P = 0.002) but not @entity4 (P = 0.2) was associated with microalbuminuria. In @entity0 , @entity4 was associated with microalbuminuria after minimal adjustment (OR 1.28, P = 0.01), but not after multivariable adjustment (OR 1.03, P = 0.8). In multivariable models in @entity0 , @entity4 was associated with a decreased odds of having microalbuminuria (OR 0.75 per s.d., P = 0.03). In conclusion, @entity4 is associated with microalbuminuria in @entity0 but not @entity0 . @entity1 may be a manifestation of @entity5 .

title: Association of subcutaneous and XXXX with @entity1 : the Framingham Heart Study.

answer: @entity5


abstract: Microalbuminuria is a common condition associated with increased incidence of cardiovascular events and mortality. @entity3 is associated with microalbuminuria, but studies linking @entity4 ( @entity4 ) and microalbuminuria are limited. Our objective was to determine the associations of @entity1 with @entity4 and @entity4 ( @entity4 ). We performed a cross-sectional study in the Framingham Multi-Detector Computed Tomography (MDCT) cohort (n = 3099, 48.2% @entity0 , mean age 53 years). @entity4 and @entity4 volumes were measured using computed tomography. Urinary albumin-to- @entity2 ratio (UACR) was calculated from spot urine samples. Microalbuminuria was defined as a UACR >25 mg/g in @entity0 or >17 mg/g in @entity0 . Overall, 7.9% (n = 244) of the sample had microalbuminuria. Among @entity0 , @entity4 ( @entity6 per s.d., P < 0.0001) and @entity4 (OR 1.37 per s.d., P = 0.0002) were associated with microalbuminuria in minimally adjusted models, which remained significant after multivariable adjustment ( @entity4 OR 1.34 per s.d., P = 0.001; @entity4 OR 1.28 per s.d., P = 0.005). Additionally, when considered jointly, @entity4 (P = 0.002) but not @entity4 (P = 0.2) was associated with microalbuminuria. In @entity0 , @entity4 was associated with microalbuminuria after minimal adjustment (OR 1.28, P = 0.01), but not after multivariable adjustment (OR 1.03, P = 0.8). In multivariable models in @entity0 , @entity4 was associated with a decreased odds of having microalbuminuria (OR 0.75 per s.d., P = 0.03). In conclusion, @entity4 is associated with microalbuminuria in @entity0 but not @entity0 . @entity1 may be a manifestation of @entity5 .

title: Association of subcutaneous and @entity5 with XXXX : the Framingham Heart Study.

answer: @entity1


abstract: We have previously shown that adenoviral-mediated interferon a (Ad- @entity8 ) is cytotoxic both to cells that are sensitive to recombinant interferon a ( @entity8 ) and to cells which are resistant to @entity8 . The @entity1 cell-specific cytotoxic effects of Ad- @entity8 involve three different mechanisms: 1. The direct effect of @entity8 production causing @entity1 cell death in @entity8 sensitive cells (1); 2. The direct effect of Ad- @entity8 @entity4 and high levels of @entity8 expression in @entity8 resistant @entity1 cells (2); and 3. The indirect effect of the Ad- @entity8 bystander factors produced (2-4). After Ad- @entity8 @entity4 , the cells produce a large amount of perinuclear localized IFN protein. This protein over-load could be a major factor in the direct @entity1 cell death of those cells infected with Ad- @entity8 compared with the indirect cytotoxic effects of the bystander factors produced. Here, we investigated whether a component of Ad-IFN-induced cell death involves @entity6 -induced endoplasmic reticulum (ER) stress, using an @entity8 -resistant @entity0 @entity3 cell line (KU7), and the normal @entity0 urothelial cell line, TERT-NHUC, as preclinical models. We found that the two ER stress response pathways examined were activated in KU7 cells. In contrast, following treatment of the normal TERT-NHUC cells with Ad- @entity8 , no ER stress signals were observed. In addition, no ER stress related changes were seen, when KU7 cells were exposed to conditioned medium from Ad- @entity8 -treated KU7 cells, indicating that bystander produced @entity2 did not involve ER stress. After 24   h of Ad- @entity8 @entity4 , the KU7 @entity1 cells produced spliced @entity9 and @entity10 protein ( @entity10 ), evoking an ER stress response that could contribute to Ad- @entity8 induced apoptosis in these @entity1 cells. In addition, @entity7 / @entity7 , @entity11 and @entity5 were also subsequently modified following activation of the ER stress pathways, thereby signaling downstream effectors in a pro-apoptotic manner.

title: Direct gene transfer of adenoviral-mediated interferon a into @entity0 @entity3 cells but not the bystander factors produced induces endoplasmic reticulum stress-related XXXX .

answer: @entity2


abstract: We have previously shown that adenoviral-mediated interferon a (Ad- @entity8 ) is cytotoxic both to cells that are sensitive to recombinant interferon a ( @entity8 ) and to cells which are resistant to @entity8 . The @entity1 cell-specific cytotoxic effects of Ad- @entity8 involve three different mechanisms: 1. The direct effect of @entity8 production causing @entity1 cell death in @entity8 sensitive cells (1); 2. The direct effect of Ad- @entity8 @entity4 and high levels of @entity8 expression in @entity8 resistant @entity1 cells (2); and 3. The indirect effect of the Ad- @entity8 bystander factors produced (2-4). After Ad- @entity8 @entity4 , the cells produce a large amount of perinuclear localized IFN protein. This protein over-load could be a major factor in the direct @entity1 cell death of those cells infected with Ad- @entity8 compared with the indirect cytotoxic effects of the bystander factors produced. Here, we investigated whether a component of Ad-IFN-induced cell death involves @entity6 -induced endoplasmic reticulum (ER) stress, using an @entity8 -resistant @entity0 @entity3 cell line (KU7), and the normal @entity0 urothelial cell line, TERT-NHUC, as preclinical models. We found that the two ER stress response pathways examined were activated in KU7 cells. In contrast, following treatment of the normal TERT-NHUC cells with Ad- @entity8 , no ER stress signals were observed. In addition, no ER stress related changes were seen, when KU7 cells were exposed to conditioned medium from Ad- @entity8 -treated KU7 cells, indicating that bystander produced @entity2 did not involve ER stress. After 24   h of Ad- @entity8 @entity4 , the KU7 @entity1 cells produced spliced @entity9 and @entity10 protein ( @entity10 ), evoking an ER stress response that could contribute to Ad- @entity8 induced apoptosis in these @entity1 cells. In addition, @entity7 / @entity7 , @entity11 and @entity5 were also subsequently modified following activation of the ER stress pathways, thereby signaling downstream effectors in a pro-apoptotic manner.

title: Direct gene transfer of adenoviral-mediated interferon a into @entity0 XXXX cells but not the bystander factors produced induces endoplasmic reticulum stress-related @entity2 .

answer: @entity3


abstract: We have previously shown that adenoviral-mediated interferon a (Ad- @entity8 ) is cytotoxic both to cells that are sensitive to recombinant interferon a ( @entity8 ) and to cells which are resistant to @entity8 . The @entity1 cell-specific cytotoxic effects of Ad- @entity8 involve three different mechanisms: 1. The direct effect of @entity8 production causing @entity1 cell death in @entity8 sensitive cells (1); 2. The direct effect of Ad- @entity8 @entity4 and high levels of @entity8 expression in @entity8 resistant @entity1 cells (2); and 3. The indirect effect of the Ad- @entity8 bystander factors produced (2-4). After Ad- @entity8 @entity4 , the cells produce a large amount of perinuclear localized IFN protein. This protein over-load could be a major factor in the direct @entity1 cell death of those cells infected with Ad- @entity8 compared with the indirect cytotoxic effects of the bystander factors produced. Here, we investigated whether a component of Ad-IFN-induced cell death involves @entity6 -induced endoplasmic reticulum (ER) stress, using an @entity8 -resistant @entity0 @entity3 cell line (KU7), and the normal @entity0 urothelial cell line, TERT-NHUC, as preclinical models. We found that the two ER stress response pathways examined were activated in KU7 cells. In contrast, following treatment of the normal TERT-NHUC cells with Ad- @entity8 , no ER stress signals were observed. In addition, no ER stress related changes were seen, when KU7 cells were exposed to conditioned medium from Ad- @entity8 -treated KU7 cells, indicating that bystander produced @entity2 did not involve ER stress. After 24   h of Ad- @entity8 @entity4 , the KU7 @entity1 cells produced spliced @entity9 and @entity10 protein ( @entity10 ), evoking an ER stress response that could contribute to Ad- @entity8 induced apoptosis in these @entity1 cells. In addition, @entity7 / @entity7 , @entity11 and @entity5 were also subsequently modified following activation of the ER stress pathways, thereby signaling downstream effectors in a pro-apoptotic manner.

title: Direct gene transfer of adenoviral-mediated interferon a into XXXX @entity3 cells but not the bystander factors produced induces endoplasmic reticulum stress-related @entity2 .

answer: @entity0


abstract: PURPOSE: Creation of a temporary loop ileostomy is a standard surgical procedure. This study was undertaken to determine whether dehydration associated with the ileostomy causes @entity1 . METHODS: The prospective data from 107 consecutive @entity0 undergoing temporary loop ileostomy between 2004 and 2009 was evaluated. GFR was calculated at the time of hospital discharge after constructing the ileostomy and at the time of deciding to close the ileostomy. RESULTS: The average GFR at the time of discharge after constructing the ileostomy was a median of 92.50 (60.75-223.88); at the time of deciding to close the ileostomy, it was 75.25 (4-135.13) ml/ @entity2 .73  m(2) (p   <   0.001). In 20 @entity0 renal function decreased, with a GFR <60  ml/ @entity2 .73  m(2) during the ileostomy period; in six of these 20 @entity0 , the decrease was severe (GFR <30  ml/ @entity2 .73  m(2)). Underlying diseases, reasons for constructing ileostomies, sex, and time interval to closure did not affect renal function. @entity0 in whom GFR was decreased at the time of deciding to close the ileostomy presented with significantly more closure-related surgical complications. CONCLUSIONS: @entity1 is a well-known potential complication of loop ileostomy. To avoid this complication, close control and backup support is recommended in these @entity0 .

title: XXXX caused by temporary loop ileostomy.

answer: @entity1


abstract: The tethered @entity2 is a disease that is part of the group of @entity6 , that was recently recognized as an individualized nosological entity, yet not frequently diagnosed among us. It is characterized by shortening and thickening of the filum terminale which prevents the ascent of the spinal cord into spinal canal, the conus medularis abnormally remaining in a low place. It is associated in all cases with @entity6 . The diagnosis is simple, once the disease is suspected. It is manifested by progressive @entity5 , @entity1 , @entity4 and @entity3 , specially in young @entity0 . The plain @entity7 always shows @entity6 . Myelography makes the diagnostic. It shows, basically, the negative image of the thickened filum terminale and the low placed conus medularis. Other exams which can help are the computerized tomography and the ultra-sound of the spinal cord. The surgical treatment is very simple and heals without sequels if done in due time. It consists in a sectioning of the filum terminale through laminectomy. Two cases diagnosed and treated at Hospital da Baleia, from Funda    o Benjamin Guimar  cs, Belo Horizonte, are reported in this paper.

title: [Tethered XXXX : report of 2 cases].

answer: @entity2


abstract: A Denver peritoneovenous (PV) shunt was inserted in 54 consecutive @entity0 for relief of malignant (24 @entity0 ) or cirrhotic (30) refractory ascites. The median age of both groups was 58 years, and the most frequent diagnoses were @entity3 and @entity16 (25). Median survival time was 1.7 and 3.5 months (range, 0.1-15.5 and 0.1-50.5), and the 1-month mortality 42% and 27%, respectively. Postoperative 24-h urinary output increased by 2-31, and the 1-week weight reduction was 8 and 11 kg, respectively, compared with before shunting. @entity6 was encountered early in two @entity0 , due to catheter malposition and clotting. Four more @entity0 experienced transient failure, for an early dysfunction rate of 11%. A shunt-related operative mortality of 6% was caused by @entity1 (two @entity0 ) and @entity7 (one @entity0 ). Shunt malfunction intervened in almost half (6 of 14) of the @entity2 @entity0 surviving 1 month but was relieved in all but 1. In 3 of 22 cirrhotic 1-month survivors, the Denver shunt had to be removed owing to clotting or @entity7 (2 @entity0 ) or revised because of blockage. Seven @entity0 with @entity4 are alive a median of 18 months (range, 2-51) after PV shunt surgery. Side effects were detected in 22 @entity0 (41%): @entity13 (9 @entity0 ), @entity7 (7), @entity9 oesophageal varices (3), @entity11 (2), postoperative @entity15 (2), @entity12 (2), and @entity1 (2). @entity0 with @entity14 or severe @entity8 did not benefit from the procedure. A history of @entity5 or a serum @entity10 level above about 100 mumol/l was a bad prognostic sign. We could confirm the reported considerable morbidity and mortality after PV shunting, but also its efficiency in certain cases. Careful @entity0 selection and follow-up study, timing of operation, and adherence to technical details are mandatory to improve the results.

title: Denver peritoneovenous shunting for XXXX . A prospective consecutive series.

answer: @entity2


abstract: In the treatment of refractory @entity6 antiarrhythmic drugs must sometimes be combined. An electrophysiologically appropriate combination is @entity9 and @entity8 and, when needed, @entity2 -blocking agent. The hemodynamic effects of this treatment were studied in 6 @entity0 in the acute phase of @entity4 . After a control period, an infusion of @entity9 was started and 1 h later @entity8 /placebo was added in a double-blind system and finally also @entity10 /placebo. The drugs were given intravenously in ordinary doses. Hemodynamics were studied by bedside catheterization. During triple treatment heart rate and aortic pressures fell significantly whereas right atrial mean pressure increased compared to the control period. @entity1 volume, cardiac output and pulmonary artery pressures were unchanged. Most of the changes appeared when @entity10 was added. Following the @entity8 injection a transient fall in aortic pressures was noted. @entity9 gave no hemodynamic effects. The number of ventricular premature beats was reduced in all @entity0 and no @entity0 had @entity6 during treatment. In these @entity0 it was possible to combine @entity9 , @entity8 and @entity10 in the acute phase of @entity4 . However, 3 @entity0 developed @entity3 , 1 sinus @entity7 and 1 had a short run of @entity5 . It is concluded that this kind of combined treatment, because of its potential risks, should be restricted to critical clinical situations and then it ought to be hemodynamically controlled.

title: Hemodynamic effects of combined treatment with XXXX , @entity8 and @entity10 in acute @entity4 .

answer: @entity9


abstract: In the treatment of refractory @entity6 antiarrhythmic drugs must sometimes be combined. An electrophysiologically appropriate combination is @entity9 and @entity8 and, when needed, @entity2 -blocking agent. The hemodynamic effects of this treatment were studied in 6 @entity0 in the acute phase of @entity4 . After a control period, an infusion of @entity9 was started and 1 h later @entity8 /placebo was added in a double-blind system and finally also @entity10 /placebo. The drugs were given intravenously in ordinary doses. Hemodynamics were studied by bedside catheterization. During triple treatment heart rate and aortic pressures fell significantly whereas right atrial mean pressure increased compared to the control period. @entity1 volume, cardiac output and pulmonary artery pressures were unchanged. Most of the changes appeared when @entity10 was added. Following the @entity8 injection a transient fall in aortic pressures was noted. @entity9 gave no hemodynamic effects. The number of ventricular premature beats was reduced in all @entity0 and no @entity0 had @entity6 during treatment. In these @entity0 it was possible to combine @entity9 , @entity8 and @entity10 in the acute phase of @entity4 . However, 3 @entity0 developed @entity3 , 1 sinus @entity7 and 1 had a short run of @entity5 . It is concluded that this kind of combined treatment, because of its potential risks, should be restricted to critical clinical situations and then it ought to be hemodynamically controlled.

title: Hemodynamic effects of combined treatment with @entity9 , XXXX and @entity10 in acute @entity4 .

answer: @entity8


abstract: In the treatment of refractory @entity6 antiarrhythmic drugs must sometimes be combined. An electrophysiologically appropriate combination is @entity9 and @entity8 and, when needed, @entity2 -blocking agent. The hemodynamic effects of this treatment were studied in 6 @entity0 in the acute phase of @entity4 . After a control period, an infusion of @entity9 was started and 1 h later @entity8 /placebo was added in a double-blind system and finally also @entity10 /placebo. The drugs were given intravenously in ordinary doses. Hemodynamics were studied by bedside catheterization. During triple treatment heart rate and aortic pressures fell significantly whereas right atrial mean pressure increased compared to the control period. @entity1 volume, cardiac output and pulmonary artery pressures were unchanged. Most of the changes appeared when @entity10 was added. Following the @entity8 injection a transient fall in aortic pressures was noted. @entity9 gave no hemodynamic effects. The number of ventricular premature beats was reduced in all @entity0 and no @entity0 had @entity6 during treatment. In these @entity0 it was possible to combine @entity9 , @entity8 and @entity10 in the acute phase of @entity4 . However, 3 @entity0 developed @entity3 , 1 sinus @entity7 and 1 had a short run of @entity5 . It is concluded that this kind of combined treatment, because of its potential risks, should be restricted to critical clinical situations and then it ought to be hemodynamically controlled.

title: Hemodynamic effects of combined treatment with @entity9 , @entity8 and XXXX in acute @entity4 .

answer: @entity10


abstract: In the treatment of refractory @entity6 antiarrhythmic drugs must sometimes be combined. An electrophysiologically appropriate combination is @entity9 and @entity8 and, when needed, @entity2 -blocking agent. The hemodynamic effects of this treatment were studied in 6 @entity0 in the acute phase of @entity4 . After a control period, an infusion of @entity9 was started and 1 h later @entity8 /placebo was added in a double-blind system and finally also @entity10 /placebo. The drugs were given intravenously in ordinary doses. Hemodynamics were studied by bedside catheterization. During triple treatment heart rate and aortic pressures fell significantly whereas right atrial mean pressure increased compared to the control period. @entity1 volume, cardiac output and pulmonary artery pressures were unchanged. Most of the changes appeared when @entity10 was added. Following the @entity8 injection a transient fall in aortic pressures was noted. @entity9 gave no hemodynamic effects. The number of ventricular premature beats was reduced in all @entity0 and no @entity0 had @entity6 during treatment. In these @entity0 it was possible to combine @entity9 , @entity8 and @entity10 in the acute phase of @entity4 . However, 3 @entity0 developed @entity3 , 1 sinus @entity7 and 1 had a short run of @entity5 . It is concluded that this kind of combined treatment, because of its potential risks, should be restricted to critical clinical situations and then it ought to be hemodynamically controlled.

title: Hemodynamic effects of combined treatment with @entity9 , @entity8 and @entity10 in acute XXXX .

answer: @entity4


abstract: PURPOSE: To evaluate the safety and efficacy of the Amplatzer vascular plug (AVP) for embolization of the splenic artery in @entity0 with @entity1 after orthotopic liver transplantation (OLT). MATERIALS AND METHODS: Thirteen @entity0 (9 @entity0 and 4 @entity0 ) with a mean age of 56 years (range 22-70) who developed @entity3 after OLT with decreased liver perfusion and clinically relevant @entity2 (increased transaminase or serum @entity4 levels, @entity5 , and/or therapy-refractory ascites) were treated by embolization of the proximal third of the splenic artery using the AVP. The plugs ranged in diameter from 6 to 16 mm, and they were introduced through femoral (n = 9), axillary (n = 3), or brachial (n = 1) access using a 5F or 8F guiding catheter. RESULTS: The plugs were successfully placed, and @entity3 was achieved in all @entity0 . Placement of two plugs was necessary for complete occlusion in 3 of the 13 @entity0 . Occlusion took on average 10 min (range 4-35). There was no nontarget embolization or plug migration into more distal segments of the splenic artery. All @entity0 showed improved arterial perfusion, including the liver periphery, on postinterventional angiogram. After embolization, liver function parameters (transaminase and @entity4 levels) improved with normalization of concomitant @entity5 and a decrease in ascites volume. CONCLUSION: Our initial experience in a small @entity0 population with SAS suggests that the AVP enables precise embolization of the proximal splenic artery, thus providing safe and effective treatment for poor liver perfusion after OLT due to SAS.

title: XXXX after orthotopic liver transplantation: treatment with the Amplatzer vascular plug.

answer: @entity3


abstract: To provide insight into the reduced post- @entity1 all-cause mortality among Mexican Americans, we explored ethnic differences in the pre- @entity1 prevalence of (1) spirituality, (2) optimism, (3) @entity3 , and (4) @entity4 in a Mexican American and non-Hispanic white @entity1 population. The @entity2 in Corpus Christi (BASIC) project is a population-based @entity1 surveillance study in Nueces County, Texas. Seven hundred ten @entity1 @entity0 were queried. For @entity4 , optimism, and @entity3 scales, unadjusted ethnic comparisons were made using linear regression models. Regression models were also used to explore how age and gender modify the ethnic associations after adjustment for education. For the categorical spirituality variables, ethnic comparisons were made using Fisher's exact tests. Mexican Americans reported significantly more spirituality than non-Hispanic whites. Among @entity0 , age modified the ethnic associations with @entity1 and @entity4 but not optimism. Mexican American @entity0 had more optimism than non-Hispanic white @entity0 . With age, Mexican American @entity0 had less @entity3 and @entity4 , while non-Hispanic white @entity0 had more @entity4 and similar @entity3 . Among @entity0 , after adjustment for education and age, there was no ethnic association with @entity4 , @entity3 , and optimism. Spirituality requires further study as a potential mediator of increased survival following @entity1 among Mexican Americans. Among @entity0 , evaluation of the role of optimism, @entity3 , and @entity4 as they relate to ethnic differences in post- @entity1 mortality should be explored.

title: The prevalence of spirituality, optimism, XXXX , and @entity4 in a bi-ethnic @entity1 population.

answer: @entity3


abstract: To provide insight into the reduced post- @entity1 all-cause mortality among Mexican Americans, we explored ethnic differences in the pre- @entity1 prevalence of (1) spirituality, (2) optimism, (3) @entity3 , and (4) @entity4 in a Mexican American and non-Hispanic white @entity1 population. The @entity2 in Corpus Christi (BASIC) project is a population-based @entity1 surveillance study in Nueces County, Texas. Seven hundred ten @entity1 @entity0 were queried. For @entity4 , optimism, and @entity3 scales, unadjusted ethnic comparisons were made using linear regression models. Regression models were also used to explore how age and gender modify the ethnic associations after adjustment for education. For the categorical spirituality variables, ethnic comparisons were made using Fisher's exact tests. Mexican Americans reported significantly more spirituality than non-Hispanic whites. Among @entity0 , age modified the ethnic associations with @entity1 and @entity4 but not optimism. Mexican American @entity0 had more optimism than non-Hispanic white @entity0 . With age, Mexican American @entity0 had less @entity3 and @entity4 , while non-Hispanic white @entity0 had more @entity4 and similar @entity3 . Among @entity0 , after adjustment for education and age, there was no ethnic association with @entity4 , @entity3 , and optimism. Spirituality requires further study as a potential mediator of increased survival following @entity1 among Mexican Americans. Among @entity0 , evaluation of the role of optimism, @entity3 , and @entity4 as they relate to ethnic differences in post- @entity1 mortality should be explored.

title: The prevalence of spirituality, optimism, @entity3 , and @entity4 in a bi-ethnic XXXX population.

answer: @entity1


abstract: To provide insight into the reduced post- @entity1 all-cause mortality among Mexican Americans, we explored ethnic differences in the pre- @entity1 prevalence of (1) spirituality, (2) optimism, (3) @entity3 , and (4) @entity4 in a Mexican American and non-Hispanic white @entity1 population. The @entity2 in Corpus Christi (BASIC) project is a population-based @entity1 surveillance study in Nueces County, Texas. Seven hundred ten @entity1 @entity0 were queried. For @entity4 , optimism, and @entity3 scales, unadjusted ethnic comparisons were made using linear regression models. Regression models were also used to explore how age and gender modify the ethnic associations after adjustment for education. For the categorical spirituality variables, ethnic comparisons were made using Fisher's exact tests. Mexican Americans reported significantly more spirituality than non-Hispanic whites. Among @entity0 , age modified the ethnic associations with @entity1 and @entity4 but not optimism. Mexican American @entity0 had more optimism than non-Hispanic white @entity0 . With age, Mexican American @entity0 had less @entity3 and @entity4 , while non-Hispanic white @entity0 had more @entity4 and similar @entity3 . Among @entity0 , after adjustment for education and age, there was no ethnic association with @entity4 , @entity3 , and optimism. Spirituality requires further study as a potential mediator of increased survival following @entity1 among Mexican Americans. Among @entity0 , evaluation of the role of optimism, @entity3 , and @entity4 as they relate to ethnic differences in post- @entity1 mortality should be explored.

title: The prevalence of spirituality, optimism, @entity3 , and XXXX in a bi-ethnic @entity1 population.

answer: @entity4


abstract: @entity2 is the most common cause of an -acute abdomen. Around 135 000 @entity0 undergo appendectomy in Germany every year. @entity1 shows changes in epidemiology, -diagnosis and therapy. Epidemiological data indicate a continuing decrease in the incidence of @entity2 . The incidence of @entity2 has remained constant despite laparoscopy and imaging diagnostics. The status of sonography and CT scanning is increasing in the diagnosis of @entity2 . But there are differences between the sensitivity and specifity of study results and the clinical routine. The in-crease of imaging diagnostics does not correlate with a decrease in the incidence of @entity2 . Laparoscopic appendectomy has -developed as a dominant method for operative therapy. There is no proof of a higher rate of postoperative intraabdominal abscesses any more. The use of a stapler is mostly required for appendical stump closure.

title: [ XXXX - changes in epidemiology, diagnosis and therapy].

answer: @entity1


abstract: Twenty-nine @entity0 with recurrent or advanced, incurable @entity2 were entered into a phase I-II trial of @entity16 in combination with @entity11 ( @entity11 ), 1,000 mg/m2/d continuous intravenous (IV) infusion for five days every 28 days. The initial dose of @entity16 was 300 mg/m2 for @entity0 with Karnofsky performance scores greater than or equal to 70%, and 240 mg/m2 for @entity0 with scores of 50% to 60%. Subsequent doses were modified to achieve grade 2 myelo-suppression: WBC, 2,000 to 2,999 cells/microL; granulocytes, 1,000 to 1,499 cells/microL; and platelets, 50,000 to 75,000 cells/microL. Dose levels were 180, 240, 300, 360, and 420 mg/m2. Twenty-eight @entity0 had @entity13 and one had an @entity15 . There were 26 @entity0 with recurrent disease; 22 had received prior RT; only two had received other chemotherapy immediately before study entry. Three @entity0 had newly diagnosed incurable stage IV disease. The median performance status was 80% (range, 60% to 90%). All @entity0 had objectively measurable disease, and 28 were evaluable for response. There were three complete responses (CRs) and ten partial responses (PRs) (48% CR and PR); the median duration of response was 4.7 months (range, 1.5 to 15+ months). Dose-limiting @entity3 were @entity17 , @entity7 , and @entity18 . Prolonged myelosuppression delayed retreatment in eight @entity0 and delayed 19 of 107 (18%) courses. @entity18 occurred in 61% and @entity4 in 29%. @entity11 dosage was decreased in ten @entity0 (36%) for grade 2 or greater @entity18 or @entity4 . Mild to moderate @entity5 and @entity6 occurred in 66% of @entity0 trials in which no pretreatment antiemetics were administered. Other @entity3 included @entity19 from @entity11 in 71%, @entity3 in 11%, mild @entity14 in 25%, and @entity10 in 54% of @entity0 . Nephrotoxicity ( @entity9 greater than 2.0 mg/dL) occurred in one @entity0 . The dose of @entity16 resulting in grade 2 @entity3 was 180 mg/m2 in one @entity0 , 240 mg/m2 in one, 300 mg/m2 in seven, 360 mg/m2 in ten, and 420 mg/m2 in one. Based on these results, we recommend a starting dose of @entity16 , 300 mg/m2, in combination with five days of continuous infusion @entity11 . In this dose and schedule, this combination was well tolerated and demonstrated antitumor activity in @entity2 . To confirm these promising results, a Southwest Oncology Group prospective randomized trial is in progress comparing @entity16 and @entity11 , @entity8 and @entity11 , and standard-dose weekly @entity12 in @entity1 @entity0 .

title: A phase I-II trial of XXXX and @entity11 combination chemotherapy in advanced carcinoma of the @entity2 .

answer: @entity16


abstract: Twenty-nine @entity0 with recurrent or advanced, incurable @entity2 were entered into a phase I-II trial of @entity16 in combination with @entity11 ( @entity11 ), 1,000 mg/m2/d continuous intravenous (IV) infusion for five days every 28 days. The initial dose of @entity16 was 300 mg/m2 for @entity0 with Karnofsky performance scores greater than or equal to 70%, and 240 mg/m2 for @entity0 with scores of 50% to 60%. Subsequent doses were modified to achieve grade 2 myelo-suppression: WBC, 2,000 to 2,999 cells/microL; granulocytes, 1,000 to 1,499 cells/microL; and platelets, 50,000 to 75,000 cells/microL. Dose levels were 180, 240, 300, 360, and 420 mg/m2. Twenty-eight @entity0 had @entity13 and one had an @entity15 . There were 26 @entity0 with recurrent disease; 22 had received prior RT; only two had received other chemotherapy immediately before study entry. Three @entity0 had newly diagnosed incurable stage IV disease. The median performance status was 80% (range, 60% to 90%). All @entity0 had objectively measurable disease, and 28 were evaluable for response. There were three complete responses (CRs) and ten partial responses (PRs) (48% CR and PR); the median duration of response was 4.7 months (range, 1.5 to 15+ months). Dose-limiting @entity3 were @entity17 , @entity7 , and @entity18 . Prolonged myelosuppression delayed retreatment in eight @entity0 and delayed 19 of 107 (18%) courses. @entity18 occurred in 61% and @entity4 in 29%. @entity11 dosage was decreased in ten @entity0 (36%) for grade 2 or greater @entity18 or @entity4 . Mild to moderate @entity5 and @entity6 occurred in 66% of @entity0 trials in which no pretreatment antiemetics were administered. Other @entity3 included @entity19 from @entity11 in 71%, @entity3 in 11%, mild @entity14 in 25%, and @entity10 in 54% of @entity0 . Nephrotoxicity ( @entity9 greater than 2.0 mg/dL) occurred in one @entity0 . The dose of @entity16 resulting in grade 2 @entity3 was 180 mg/m2 in one @entity0 , 240 mg/m2 in one, 300 mg/m2 in seven, 360 mg/m2 in ten, and 420 mg/m2 in one. Based on these results, we recommend a starting dose of @entity16 , 300 mg/m2, in combination with five days of continuous infusion @entity11 . In this dose and schedule, this combination was well tolerated and demonstrated antitumor activity in @entity2 . To confirm these promising results, a Southwest Oncology Group prospective randomized trial is in progress comparing @entity16 and @entity11 , @entity8 and @entity11 , and standard-dose weekly @entity12 in @entity1 @entity0 .

title: A phase I-II trial of @entity16 and XXXX combination chemotherapy in advanced carcinoma of the @entity2 .

answer: @entity11


abstract: Twenty-nine @entity0 with recurrent or advanced, incurable @entity2 were entered into a phase I-II trial of @entity16 in combination with @entity11 ( @entity11 ), 1,000 mg/m2/d continuous intravenous (IV) infusion for five days every 28 days. The initial dose of @entity16 was 300 mg/m2 for @entity0 with Karnofsky performance scores greater than or equal to 70%, and 240 mg/m2 for @entity0 with scores of 50% to 60%. Subsequent doses were modified to achieve grade 2 myelo-suppression: WBC, 2,000 to 2,999 cells/microL; granulocytes, 1,000 to 1,499 cells/microL; and platelets, 50,000 to 75,000 cells/microL. Dose levels were 180, 240, 300, 360, and 420 mg/m2. Twenty-eight @entity0 had @entity13 and one had an @entity15 . There were 26 @entity0 with recurrent disease; 22 had received prior RT; only two had received other chemotherapy immediately before study entry. Three @entity0 had newly diagnosed incurable stage IV disease. The median performance status was 80% (range, 60% to 90%). All @entity0 had objectively measurable disease, and 28 were evaluable for response. There were three complete responses (CRs) and ten partial responses (PRs) (48% CR and PR); the median duration of response was 4.7 months (range, 1.5 to 15+ months). Dose-limiting @entity3 were @entity17 , @entity7 , and @entity18 . Prolonged myelosuppression delayed retreatment in eight @entity0 and delayed 19 of 107 (18%) courses. @entity18 occurred in 61% and @entity4 in 29%. @entity11 dosage was decreased in ten @entity0 (36%) for grade 2 or greater @entity18 or @entity4 . Mild to moderate @entity5 and @entity6 occurred in 66% of @entity0 trials in which no pretreatment antiemetics were administered. Other @entity3 included @entity19 from @entity11 in 71%, @entity3 in 11%, mild @entity14 in 25%, and @entity10 in 54% of @entity0 . Nephrotoxicity ( @entity9 greater than 2.0 mg/dL) occurred in one @entity0 . The dose of @entity16 resulting in grade 2 @entity3 was 180 mg/m2 in one @entity0 , 240 mg/m2 in one, 300 mg/m2 in seven, 360 mg/m2 in ten, and 420 mg/m2 in one. Based on these results, we recommend a starting dose of @entity16 , 300 mg/m2, in combination with five days of continuous infusion @entity11 . In this dose and schedule, this combination was well tolerated and demonstrated antitumor activity in @entity2 . To confirm these promising results, a Southwest Oncology Group prospective randomized trial is in progress comparing @entity16 and @entity11 , @entity8 and @entity11 , and standard-dose weekly @entity12 in @entity1 @entity0 .

title: A phase I-II trial of @entity16 and @entity11 combination chemotherapy in advanced carcinoma of the XXXX .

answer: @entity2


abstract: BACKGROUND: Endovascular repair of complex @entity3 (CAAs) can be performed in high-risk individuals, yet is still associated with significant morbidity, including @entity9 , @entity2 , and @entity1 . This analysis was undertaken to better define the cardiac risk for @entity10 . METHODS: A prospective database of @entity0 undergoing @entity8 repair with branched and fenestrated endografts was used to retrospectively determine the number of @entity2 , defined as @entity4 ( @entity4 ), @entity7 ( @entity7 ), and @entity6 ( @entity6 ), that occurred  <= 30 days of surgery. Postoperative serial troponin measurements were performed in 266 @entity0 . Any additional available cardiac information, including preoperative echocardiography, physiologic stress tests, and history of @entity2 , was obtained from medical records. The efficacy of preoperative stress testing and the association of various echo parameters were evaluated in the context of cardiac outcomes using univariable and multivariable logistic regression models. RESULTS: Between August 2001 and December 2007, 395 @entity0 underwent endovascular repair of a @entity8 . The incidence of @entity7 , @entity6 , and 30-day cardiac-related @entity1 was 9%, 3%, and 2%, respectively. Overall 30-day mortality was 6%. Univariable analysis showed the presence of @entity5 was associated with @entity4 (odds ratio [OR], 3.5; 95% confidence interval [CI], 0.9-13.8; P = .07). Left atrium cavity area, ejection fraction, left ventricle mass, and left ventricular mass index were univariably associated with the presence of @entity6 . Multivariable analysis showed only the left atrium cavity area was independently associated with @entity6 (OR, 1.2; 95% CI, 1.0-1.5; P = .07). Stress test was done in 179 @entity0 . Negative stress test results occurred in 152 (85%), of whom 9 (6%) sustained an @entity4 during the 30-day perioperative course. @entity4 occurred in 2 of the 27 @entity0 (7%) who had a positive stress test result. CONCLUSIONS: Endovascular repair of @entity10 can be performed in high-risk individuals but is associated with significant cardiac risk. It remains difficult to risk stratify @entity0 using preoperative stress testing. Echo evaluation may help to identify @entity0 who may be more likely to develop @entity6 in the postoperative period and thus warrant closer monitoring. Postoperative troponin monitoring of all @entity0 undergoing repair of @entity10 is warranted given the overall risk of @entity4 .

title: Perioperative @entity2 in endovascular repair of complex XXXX and association with preoperative studies.

answer: @entity3


abstract: BACKGROUND: Endovascular repair of complex @entity3 (CAAs) can be performed in high-risk individuals, yet is still associated with significant morbidity, including @entity9 , @entity2 , and @entity1 . This analysis was undertaken to better define the cardiac risk for @entity10 . METHODS: A prospective database of @entity0 undergoing @entity8 repair with branched and fenestrated endografts was used to retrospectively determine the number of @entity2 , defined as @entity4 ( @entity4 ), @entity7 ( @entity7 ), and @entity6 ( @entity6 ), that occurred  <= 30 days of surgery. Postoperative serial troponin measurements were performed in 266 @entity0 . Any additional available cardiac information, including preoperative echocardiography, physiologic stress tests, and history of @entity2 , was obtained from medical records. The efficacy of preoperative stress testing and the association of various echo parameters were evaluated in the context of cardiac outcomes using univariable and multivariable logistic regression models. RESULTS: Between August 2001 and December 2007, 395 @entity0 underwent endovascular repair of a @entity8 . The incidence of @entity7 , @entity6 , and 30-day cardiac-related @entity1 was 9%, 3%, and 2%, respectively. Overall 30-day mortality was 6%. Univariable analysis showed the presence of @entity5 was associated with @entity4 (odds ratio [OR], 3.5; 95% confidence interval [CI], 0.9-13.8; P = .07). Left atrium cavity area, ejection fraction, left ventricle mass, and left ventricular mass index were univariably associated with the presence of @entity6 . Multivariable analysis showed only the left atrium cavity area was independently associated with @entity6 (OR, 1.2; 95% CI, 1.0-1.5; P = .07). Stress test was done in 179 @entity0 . Negative stress test results occurred in 152 (85%), of whom 9 (6%) sustained an @entity4 during the 30-day perioperative course. @entity4 occurred in 2 of the 27 @entity0 (7%) who had a positive stress test result. CONCLUSIONS: Endovascular repair of @entity10 can be performed in high-risk individuals but is associated with significant cardiac risk. It remains difficult to risk stratify @entity0 using preoperative stress testing. Echo evaluation may help to identify @entity0 who may be more likely to develop @entity6 in the postoperative period and thus warrant closer monitoring. Postoperative troponin monitoring of all @entity0 undergoing repair of @entity10 is warranted given the overall risk of @entity4 .

title: Perioperative XXXX in endovascular repair of complex @entity3 and association with preoperative studies.

answer: @entity2


abstract: Previous studies have documented disparities in both access to invasive cardiovascular procedures and outcomes in @entity0 with Medicaid, Medicare, or no insurance. Outcomes by insurance have yet not been examined in a percutaneous coronary intervention (PCI) population. Data from @entity0 undergoing PCI from June 2000 to June 2009 were retrospectively analyzed. Insurance was categorized as private, Medicare, Medicaid, and uninsured, according to the primary insurance at discharge. The outcome variable of interest was major adverse @entity2 (a composite of @entity1 , Q-wave @entity3 , and target vessel revascularization) at 1 year. Multivariable Cox regression analysis was stratified according to age <65 and >= 65 years. Of the 13,573 @entity0 who had undergone PCI, 6,653 (49.0%) had private insurance, 6,150 (45.3%) had Medicare, 486 (3.6%) had Medicaid, and 284 (2.1%) were uninsured. Of the @entity0 <65 years old, Medicaid (hazard ratio [HR] 1.59, 95% confidence interval [CI] 1.04 to 2.43), Medicare (HR 2.18, 95% CI 1.58 to 2.99), and no insurance (HR 2.41, 95% CI 1.36 to 4.27) were associated with greater rates of adjusted major adverse @entity2 at 1 year compared with private insurance. Of the @entity0 >= 65 years old, only Medicaid (HR 3.07, 95% CI 1.09 to 8.61) was associated with a greater rate of adjusted major adverse @entity2 at 1 year. In conclusion, @entity0 with government-sponsored insurance and no insurance have worse cardiovascular outcomes than @entity0 with private insurance after PCI at 1 year. This implies that the provision of health insurance alone might not have a dramatic effect on cardiovascular outcomes after PCI.

title: Effect of insurance type on adverse XXXX after percutaneous coronary intervention.

answer: @entity2


abstract: OBJECTIVES: @entity0 with @entity1 are at high risk for suicide ideation, attempts, and completed suicide. However, suicidal behavior during the prodromal phase of @entity1 and a possible association between prodromal suicidal behavior and suicidality after the onset of overt @entity4 are not studied. METHODS: One hundred six consecutively admitted @entity1 @entity0 with recent onset were evaluated retrospectively for prodromal symptoms and suicidality during the prodromal phase and after the onset of @entity4 . In addition, 106 matched control subjects from the general population were evaluated for suicidality during the same age period of the prodromal phase of the corresponding @entity0 . RESULTS: Suicide ideation and attempt during the prodromal period were reported in 25.5% and 7.5% of the @entity0 , which are 3.8- and 8-fold greater than in the controls, respectively. @entity0 with suicidal behavior experienced a greater number of prodromal symptoms than those without. @entity3 , marked impairment in role functioning, and @entity2 smoking exerted an independent effect on suicide ideation, whereas @entity3 mood was the symptom significantly more frequent in @entity0 with suicide attempt. Suicide attempts were associated with an earlier onset of prodromal symptoms and @entity4 . All @entity0 with prodromal suicide attempts were cigarette smokers. Suicide ideation during the prodromal phase was strongly associated with lifetime suicidality after the onset of @entity4 . CONCLUSIONS: Suicidal behavior is quite common during the prodromal period. The association of smoking, @entity3 mood, impaired functioning, and a large number of prodromal symptoms, particularly in @entity0 with an early onset of symptomatology, carries a substantially increased risk for suicide ideation. Particular care is needed in @entity0 with prodromal suicide ideation after the onset of @entity4 because the risk to attempt suicide is high.

title: Suicidality in the "prodromal" phase of XXXX .

answer: @entity1


abstract: OBJECTIVES: To evaluate the efficacy and postoperative morbidity of a mini-incision vasectomy reversal (MIVR) using no-scalpel vasectomy principles compared with traditional incisional approaches to vasectomy reversal (VR). METHODS: Of 164 @entity0 undergoing consecutive VR, 139 underwent bilateral vasovasostomy (55% bilateral MIVR, 24% mixed MIVR/traditional incision VR, and 21% bilateral traditional incision VR). The MIVRs were performed using a subcentimeter incision after the vas deferens was captured and delivered through the skin using the no-scalpel vasectomy principles and instruments. Semen analyses were obtained at 3-month intervals postoperatively until pregnancy was achieved. Motile sperm in the ejaculate after VR defined patency. @entity1 and functional recovery after surgery were evaluated using a previously validated 10-point @entity1 scale adapted to VR. The no-scalpel vasectomy @entity0 served as controls for the @entity2 assessments. RESULTS: The median follow-up was 11.6 months. The patency rate was 96%, 100%, and 91% for the MIVR, mixed MIVR/traditional incision, and bilateral traditional incision VR, respectively (P = .4). The semen parameters did not significantly differ among the VR approaches. The @entity1 severity during the first 48 hours after surgery was significantly less (P < .05) for the @entity0 who had undergone bilateral MIVR than for the @entity0 who had undergone traditional incision VR and did not significantly differ from that of the @entity0 who had undergone no-scalpel vasectomy. The @entity0 returned to normal activities an average of 2 days earlier after MIVR than after traditional incision VR. CONCLUSIONS: The results of our study have shown that MIVR does not compromise patency outcomes or semen parameters compared with more traditional approaches to VR and results in @entity1 during the early period of recovery after surgery and quicker functional recovery.

title: Mini-incision vasectomy reversal using no-scalpel vasectomy principles: efficacy and XXXX compared with traditional approaches to vasectomy reversal.

answer: @entity2


abstract: After a general clinical observation period of over 4 weeks, 20 essential @entity1 subjects (Japanese) were randomly divided into two groups. One group (n = 10; 4 @entity0 and 6 @entity0 ; 51.4 +/- 2.8 years of age) agreed to physical training using bicycle ergometer exercise with the intensity at blood lactate threshold for 60 minutes three times a week for 10 weeks, while the other group (n = 10; 4 @entity0 and 6 @entity0 ; 51.0 +/- 2.9 years of age) did no particular physical training and was followed once a week as the control. Changes in blood pressure, hemodynamics, and humoral factors of the exercised group were compared with values in the controls. The following significant changes were found only in the exercised group. Blood pressure was significantly (p less than 0.01) reduced. Whole blood and plasma volume indices were significantly reduced (p less than 0.05, p less than 0.01, respectively). The change in ratio of serum @entity5 to @entity3 positively correlated with the change in systolic blood pressure (r = 0.76, p less than 0.02). Plasma @entity4 concentrations both at rest and at the workload of blood @entity2 threshold during graded exercise tests were significantly reduced (p less than 0.05, p less than 0.02 respectively) after 10 weeks of exercise training. The change in the resting level of plasma @entity4 positively correlated with that in the mean blood pressure. No such changes were observed in the control group. In both groups, body weight and urinary @entity5 excretion showed no statistically significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Antihypertensive and volume-depleting effects of mild exercise on essential XXXX .

answer: @entity1


abstract: From October 1, 1976 through July 31, 1979, at the University of Kansas Medical Center, CT/M examinations were performed on 1625 @entity1 . Seventy-eight @entity2 were histologically diagnosed. A CT/M study using our contrast medium enhancement technique yields both static anatomical changes and dynamic measurements of abnormal @entity4 concentrations in the @entity0 . This unique ability of CT/M provides many advantages as compared with conventional mammography in the diagnosis of @entity0 . The detection rate in 78 @entity2 by CT/M was 94% and 77% for the mammography. The CT/M appears to be specially superior to the mammography for detecting @entity2 in dense, @entity3 breasts. The CT/M can detect totally unsuspected @entity0 that were unable to be identified by conventional mammography or physical examinations. The CT/M scan also seems to be a better test for recognizing precancerous high risk lesions. CT/M evaluation affords definitive diagnostic help in instances where the mammographic and/or physical examinations are inconclusive. Although CT/M will not replace conventional mammography in routine breast examinations, it overcomes the limitation of mammography.

title: Computed tomography in detection and diagnosis of XXXX .

answer: @entity0


abstract: 32 hospitalized adult @entity0 with infective episodes of @entity6 were enrolled in an ongoing double-blind, placebo-controlled study comparing @entity4 with @entity1 . They were randomized to receive either 200 mg @entity4 or 1 g @entity1 , both t.i.d. orally for ten days. In the @entity4 group (15 @entity0 ), clinical response was excellent (clinical cure) in 11 and fair (clinical improvement or early reinfection) in three @entity0 with one failure. In the @entity1 group (17 @entity0 ), clinical response was excellent in six, fair in five, and poor (treatment failure) in six @entity0 . @entity4 levels at 2 h (day 5) were 2.3 to 8.2 mg/l (mean 3.9 mg/l) for serum and 1.3 to 15 mg/l (mean 4.5 mg/l) for sputum. Sputum: serum ratio was 1.2:1. @entity1 levels at 2 h were 10 to 40 mg/l (mean 19.9 mg/l) for serum and 0 to 1.5 mg/l (mean 0.3 mg/l) for sputum, with no @entity1 detected in sputum in 10 of 17 patients. Sputum: serum ratio was 0.02:1. One @entity0 in the @entity4 group had @entity3 . In the @entity1 group, four @entity0 had @entity3 and @entity2 , one had vertigo and one had transient peripheral @entity5 . @entity4 thus yielded higher sputum concentration and appeared to be more effective and better tolerated than @entity1 in infective episodes of @entity6 .

title: A double-blind randomized study comparing @entity4 and @entity1 in treating infective episodes in XXXX .

answer: @entity6


abstract: 32 hospitalized adult @entity0 with infective episodes of @entity6 were enrolled in an ongoing double-blind, placebo-controlled study comparing @entity4 with @entity1 . They were randomized to receive either 200 mg @entity4 or 1 g @entity1 , both t.i.d. orally for ten days. In the @entity4 group (15 @entity0 ), clinical response was excellent (clinical cure) in 11 and fair (clinical improvement or early reinfection) in three @entity0 with one failure. In the @entity1 group (17 @entity0 ), clinical response was excellent in six, fair in five, and poor (treatment failure) in six @entity0 . @entity4 levels at 2 h (day 5) were 2.3 to 8.2 mg/l (mean 3.9 mg/l) for serum and 1.3 to 15 mg/l (mean 4.5 mg/l) for sputum. Sputum: serum ratio was 1.2:1. @entity1 levels at 2 h were 10 to 40 mg/l (mean 19.9 mg/l) for serum and 0 to 1.5 mg/l (mean 0.3 mg/l) for sputum, with no @entity1 detected in sputum in 10 of 17 patients. Sputum: serum ratio was 0.02:1. One @entity0 in the @entity4 group had @entity3 . In the @entity1 group, four @entity0 had @entity3 and @entity2 , one had vertigo and one had transient peripheral @entity5 . @entity4 thus yielded higher sputum concentration and appeared to be more effective and better tolerated than @entity1 in infective episodes of @entity6 .

title: A double-blind randomized study comparing @entity4 and XXXX in treating infective episodes in @entity6 .

answer: @entity1


abstract: 32 hospitalized adult @entity0 with infective episodes of @entity6 were enrolled in an ongoing double-blind, placebo-controlled study comparing @entity4 with @entity1 . They were randomized to receive either 200 mg @entity4 or 1 g @entity1 , both t.i.d. orally for ten days. In the @entity4 group (15 @entity0 ), clinical response was excellent (clinical cure) in 11 and fair (clinical improvement or early reinfection) in three @entity0 with one failure. In the @entity1 group (17 @entity0 ), clinical response was excellent in six, fair in five, and poor (treatment failure) in six @entity0 . @entity4 levels at 2 h (day 5) were 2.3 to 8.2 mg/l (mean 3.9 mg/l) for serum and 1.3 to 15 mg/l (mean 4.5 mg/l) for sputum. Sputum: serum ratio was 1.2:1. @entity1 levels at 2 h were 10 to 40 mg/l (mean 19.9 mg/l) for serum and 0 to 1.5 mg/l (mean 0.3 mg/l) for sputum, with no @entity1 detected in sputum in 10 of 17 patients. Sputum: serum ratio was 0.02:1. One @entity0 in the @entity4 group had @entity3 . In the @entity1 group, four @entity0 had @entity3 and @entity2 , one had vertigo and one had transient peripheral @entity5 . @entity4 thus yielded higher sputum concentration and appeared to be more effective and better tolerated than @entity1 in infective episodes of @entity6 .

title: A double-blind randomized study comparing XXXX and @entity1 in treating infective episodes in @entity6 .

answer: @entity4


abstract: BACKGROUND: We conducted a retrospective analysis to investigate treatment results and prognostic factors of pediatric @entity3 @entity0 . METHODS: This retrospective study was carried out analyzing the medical records of @entity0 with the pathological diagnosis of @entity3 seen at South Egypt Cancer Institute, Assiut University during the period from January 2001 and January 2010. After induction chemotherapy, response according to international neuoblastoma response criteria was assessed. Radiotherapy to @entity0 with residual primary @entity1 was applied. Overall and event free survival ( @entity5 and EFS) rates were estimated using Graphed prism program. The Log-rank test was used to examine differences in @entity5 and EFS rates. Cox-regression multivariate analysis was done to determine the independent prognostic factors affecting survival rates. RESULTS: Fifty three cases were analyzed. The median follow-up duration was 32 months and ranged from 2 to 84 months. The 3-year @entity5 and EFS rates were 39.4% and 29.3% respectively. Poor prognostic factors included age >1 year of age, @entity4 amplification, and high risk group. The majority of @entity0 (68%) presented in high risk group, where treatment outcome was poor, as only 21% of @entity0 survived for 3 year. CONCLUSION: Multivariate analysis confirmed only the association between survival and risk group. However, in univariate analysis, local radiation therapy resulted in significant survival improvement. Therefore, radiotherapy should be given to @entity0 with @entity2 evident after induction chemotherapy and surgery. Future attempts to improve @entity5 in high risk group @entity0 with aggressive chemotherapy and bone marrow transplantation should be considered.

title: Treatment results and prognostic factors of pediatric XXXX : a retrospective study.

answer: @entity3


abstract: The approach to @entity3 , as recommended in this article, is derived from understanding the mechanism of injury. Fractures that are inherently unstable can be recognized by observing the depth of comminution presented on the lateral postreduction radiography. These unstable @entity1 demand a more vigorous approach to achieve the result our @entity0 have come to demand. External fixators, percutaneous pinning, and bone grafting have all been successfully used to achieve a satisfactory result. Fortunately, the majority of Colles' @entity1 are stable and can be treated by accurate closed reduction and immobilization in plaster. If the @entity1 results in loss of containment of the carpus, a chronically weak and sometimes painful wrist will result. This event can be remedied surgically. The final emphasis I would like to impart is the prevention of sympathetic reflex @entity2 . Early involvement by the @entity0 in their rehabilitation process is essential in minimizing this condition. Understanding and application of the principles I have presented will result in @entity0 pleased with the result of their care and, consequently, with their physician.

title: A rational approach for the recognition and treatment of XXXX .

answer: @entity3


abstract: To determine bronchial reactivity patterns in adults, 211 subjects, 22 to 86 years of age, underwent a @entity4 challenge in a Natural History of Asthma study. The diagnosis of @entity3 or nonasthmatic @entity1 was based on a standardized respiratory questionnaire. Subjects were nonsmokers and had not had an @entity2 for 1 month. Intradermal skin tests were done to a battery of common antigens. The @entity4 challenge response was expressed as the area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units. Thirty-three subjects with @entity3 , 47 normal subjects from normal families (NF), 59 normal subjects from families with @entity3 (AF), 31 allergic subjects without @entity3 , 23 subjects with questionable @entity3 , and 18 subjects with prior @entity3 were studied. Overall, 50% of the subjects without @entity3 had a negative response to @entity4 . There was a difference (p less than 0.02) in the distribution of log10 @entity4 area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units responses in normal subjects from NFs compared to normal subjects from AFs. The allergic subjects from AF had a greater degree of bronchial reactivity compared to normal individuals from NF. The age of the normal subjects had an influence on the degree of bronchial reactivity. @entity4 challenge studies in adult @entity0 need to be interpreted with age and family history in mind.

title: Distribution of XXXX inhalation challenge responses in a selected adult population.

answer: @entity4


abstract: The pancreatic exocrine secretion responses to distension of the thoracic oesophagus were studied in @entity4 anesthetized @entity0 and decerebrated @entity0 occluded the pyloric sphincter with submucosal ligature. In 79 of 149 distensions, the pancreatic outflow was increased by 70.6% of control value before the distension with latencies of one to five minutes. This response was accompanied by the increased protein and @entity2 outputs of 83.1% and 303.0% of control value, respectively. In 68 of 149 distensions, the pancreatic outflow, protein and @entity2 outputs were decreased by 23.2%, 17.1% and 29.1% of control value, respectively. After transthoracic vagotomy immediately above the diaphragm or administration of @entity3 , the increased response was abolished, but the decreased one was not. The decreased response was markedly reduced by @entity1 , and completely abolished after following adrenalectomy. Furthermore, it was completely abolished after splanchnicotomy, too. There was no relationship between the pancreatic exocrine secretion and the serum @entity5 concentration before and after distension of the oesophagus. These results provide an evidence for the existence of the oesophago-pancreatic excitatory and inhibitory responses. The excitatory one is due to the vago-vagal reflex and the inhibitory one is due to the vago-splanchnic reflex.

title: [Effects of esophageal distension on XXXX pancreatic exocrine secretion].

answer: @entity0


abstract: Presented is a case of @entity4 of the cecum metastatic to the anterior mandible. The @entity0 had a Duke's C2 @entity4 resected twenty months prior to her development of loose teeth, @entity2 , and jaw mass. A biopsy of the mass revealed @entity4 , identical to her primary @entity1 . @entity3 to the mandible is a rare event. A review of the literature reveals only nineteen cases of @entity5 metastatic to the jaw. When further subdivided, there is only one other case of @entity4 metastasizing to the jaw. Almost half of the other cases have been @entity3 . Treatment of these @entity0 has been uniformly unsuccessful, with life expectancy reported between one and seven months. The literature has shown that @entity7 and radiotherapy may produce @entity6 . The @entity0 presented here responded well to @entity7 and radiotherapy.

title: Metastatic XXXX to the jaw: a case report and review of the literature.

answer: @entity5


abstract: A case of @entity2 similar to @entity9 is reported. A 21-year-old @entity0 was injured in the traffic accident and admitted to our hospital with @entity4 state. Bilateral carotid angiograms revealed no abnormal findings. Then, he was treated conservatively as a diagnosis of @entity1 . Nine years after the initial admission, he was fallen into @entity4 state suddenly and admitted to a local hospital. On the next day, he was transferred to our hospital. Neurological examination disclosed @entity4 state, right oculomotor palsy, and left @entity5 . CT scan showed a crescent shaped high density area in the right subdural space, right temporal intracerebral high density area, and left frontal low density area, suggesting right acute subdural @entity6 , right temporal @entity7 , and left frontal old @entity1 respectively. Right carotid angiogram revealed an abnormal vascularity in the right middle fossa, which was fed by the middle meningeal artery and drained into the superior sagittal sinus and the transverse sinus. Surgical treatment was performed immediately. Following the evacuation of @entity7 , the abnormal vascular mass suggesting a nidus of @entity9 was removed totally, that was attached to the dura mater. Pathological specimen showed large veins and arteries with @entity3 , however, no characteristic feature of @entity9 . Then, this was thought to be an arteriovenous fistula between the branches of middle meningeal artery and the veins of @entity8 following by the @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of XXXX similar to @entity9 ].

answer: @entity2


abstract: A case of @entity2 similar to @entity9 is reported. A 21-year-old @entity0 was injured in the traffic accident and admitted to our hospital with @entity4 state. Bilateral carotid angiograms revealed no abnormal findings. Then, he was treated conservatively as a diagnosis of @entity1 . Nine years after the initial admission, he was fallen into @entity4 state suddenly and admitted to a local hospital. On the next day, he was transferred to our hospital. Neurological examination disclosed @entity4 state, right oculomotor palsy, and left @entity5 . CT scan showed a crescent shaped high density area in the right subdural space, right temporal intracerebral high density area, and left frontal low density area, suggesting right acute subdural @entity6 , right temporal @entity7 , and left frontal old @entity1 respectively. Right carotid angiogram revealed an abnormal vascularity in the right middle fossa, which was fed by the middle meningeal artery and drained into the superior sagittal sinus and the transverse sinus. Surgical treatment was performed immediately. Following the evacuation of @entity7 , the abnormal vascular mass suggesting a nidus of @entity9 was removed totally, that was attached to the dura mater. Pathological specimen showed large veins and arteries with @entity3 , however, no characteristic feature of @entity9 . Then, this was thought to be an arteriovenous fistula between the branches of middle meningeal artery and the veins of @entity8 following by the @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of @entity2 similar to XXXX ].

answer: @entity9


abstract: Ninety-nine @entity0 with @entity3 of the membranes (PROM) before 36 weeks' gestation and documented @entity4 were studied prospectively. Fifty-two @entity0 in labor were allowed to deliver. The remaining 47 were randomly assigned to either prompt delivery (N = 26) or conservative management (N = 21). The overall corrected perinatal survival was excellent (96%). Only one death in the entire series clearly was due to prematurity. Expectant management prolonged gestation greater than one week in only four of 21 @entity0 (19%), and was associated with a significantly increased risk of @entity1 . There were no failed inductions of labor, and 22 of 24 induced @entity0 (92%) delivered vaginally. Neonatal morbidity was similar in each group. These findings in an indigent, largely black population suggest that when @entity2 is present, the maternal risks of conservative management may exceed the potential benefit to the fetus and newborn. The findings of this study may be specific to the population studied, and extrapolation to dissimilar populations may not be warranted.

title: Preterm XXXX of the membranes with @entity4 present: a prospective study.

answer: @entity3


abstract: Ninety-nine @entity0 with @entity3 of the membranes (PROM) before 36 weeks' gestation and documented @entity4 were studied prospectively. Fifty-two @entity0 in labor were allowed to deliver. The remaining 47 were randomly assigned to either prompt delivery (N = 26) or conservative management (N = 21). The overall corrected perinatal survival was excellent (96%). Only one death in the entire series clearly was due to prematurity. Expectant management prolonged gestation greater than one week in only four of 21 @entity0 (19%), and was associated with a significantly increased risk of @entity1 . There were no failed inductions of labor, and 22 of 24 induced @entity0 (92%) delivered vaginally. Neonatal morbidity was similar in each group. These findings in an indigent, largely black population suggest that when @entity2 is present, the maternal risks of conservative management may exceed the potential benefit to the fetus and newborn. The findings of this study may be specific to the population studied, and extrapolation to dissimilar populations may not be warranted.

title: Preterm @entity3 of the membranes with XXXX present: a prospective study.

answer: @entity4


abstract: The following perinatal intensive care management protocol is suggested to minimize morbidity and mortality in multiple pregnancy. 1. Early diagnosis is essential, with ultrasound examination regarding as invaluable for all pregnant @entity0 . If ultrasound examination has not been done, multiple pregnancy should be suspected in all @entity0 who have a family history of dizygotic births, are large for dates or anemic, or have a low-grade preeclampsia. 2. Maternal care should be provided at a tertiary care (level III) perinatatl center, which is more fully equipped to manage @entity3 . 3. Bed rest, if instituted early enough (26-29 weeks) appears to be of value, especially in promoting increased birth weight. 4. A liberal approach to performing cesarean birth is suggested when any abnormal presentation exists. 5. Aggressive management, using tocolytic agents to delay @entity2 and @entity1 to accelerate pulmonary maturity, should be strongly considered. 6. The personnel of a neonatal intensive care unit should employ a team approach to the preparation for and management of multiple preterm births.

title: Management of XXXX .

answer: @entity3


abstract: Although @entity2 is a rare and potentially @entity1 , 10 cases were documented during a 5-year period at the University of Toronto Perinatal Complex. Diagnosis was made in the six cases in which prenatal ultrasound examination was performed. One @entity0 with twins elected to terminate the pregnancy at 19 weeks. In three of the cases diagnosed prenatally, serial ultrasound was performed. There was a 75% cesarean section rate. In all cases diagnosed prenatally, the large @entity1 size affected the mode of delivery. In the four cases without prenatal diagnosis, two @entity0 were delivered vaginally, and two were delivered abdominally for obstetric reasons. There was one case of neonatal morbidity where @entity1 vascularity and @entity3 resulted in @entity4 . All @entity1 were resected and found to be benign. A plan of management is recommended and, with appropriate obstetric and pediatric care, a good outcome can be anticipated in most cases.

title: XXXX : prenatal diagnosis and management.

answer: @entity2


abstract: @entity1 -induced arterial contraction in vitro is known to be increased after endothelial denudation and during the subsequent development of intimal @entity2 . We now report the response to @entity1 in intimal-thickened iliac vessels in conscious @entity0 . Seven @entity0 underwent balloon catheter deendothelialization of the right iliac artery. Three weeks later, ultrasonic transducers were implanted on both iliac arteries to record dynamic vessel dimension. A catheter was inserted into the terminal abdominal aorta for drug infusion and blood pressure monitoring. The @entity0 were studied unsedated 2 days after instrumentation. @entity1 was infused at doses that did not affect blood pressure (0.01 to 0.05 micrograms/kg/min). Control vessel diameter decreased from 5.2 mm +/- 0.3 to 5.1 mm +/- 0.3 (2.4% +/- 1.0% when standardized to baseline diameter) and intimal hyperplastic vessels from 6.2 mm +/- 0.4 to 5.7 mm +/- 0.4 (7.6% +/- 1.7%). The difference between control and intimal hyperplastic vessel vasoconstriction was significant at p less than 0.0025. The calculated reduction in total vessel cross-section area for control vessels was 4.5% +/- 1.9%. In intimal hyperplastic vessels total cross-sectional area was reduced by 14.5% +/- 3.3% by vasoconstriction and the luminal cross-sectional area was reduced by 17.9% +/- 0.7% by the intimal @entity2 . These data suggest that luminal compromise due to intimal @entity2 is compounded by increased sensitivity to @entity1 . This effect, demonstrated in a large elastic artery shortly after endothelial denudation, may be of even greater significance in a smaller vessel with advanced intimal @entity2 .

title: XXXX -induced vasoconstriction is increased in intimal hyperplastic arteries of the @entity0 .

answer: @entity1


abstract: @entity1 -induced arterial contraction in vitro is known to be increased after endothelial denudation and during the subsequent development of intimal @entity2 . We now report the response to @entity1 in intimal-thickened iliac vessels in conscious @entity0 . Seven @entity0 underwent balloon catheter deendothelialization of the right iliac artery. Three weeks later, ultrasonic transducers were implanted on both iliac arteries to record dynamic vessel dimension. A catheter was inserted into the terminal abdominal aorta for drug infusion and blood pressure monitoring. The @entity0 were studied unsedated 2 days after instrumentation. @entity1 was infused at doses that did not affect blood pressure (0.01 to 0.05 micrograms/kg/min). Control vessel diameter decreased from 5.2 mm +/- 0.3 to 5.1 mm +/- 0.3 (2.4% +/- 1.0% when standardized to baseline diameter) and intimal hyperplastic vessels from 6.2 mm +/- 0.4 to 5.7 mm +/- 0.4 (7.6% +/- 1.7%). The difference between control and intimal hyperplastic vessel vasoconstriction was significant at p less than 0.0025. The calculated reduction in total vessel cross-section area for control vessels was 4.5% +/- 1.9%. In intimal hyperplastic vessels total cross-sectional area was reduced by 14.5% +/- 3.3% by vasoconstriction and the luminal cross-sectional area was reduced by 17.9% +/- 0.7% by the intimal @entity2 . These data suggest that luminal compromise due to intimal @entity2 is compounded by increased sensitivity to @entity1 . This effect, demonstrated in a large elastic artery shortly after endothelial denudation, may be of even greater significance in a smaller vessel with advanced intimal @entity2 .

title: @entity1 -induced vasoconstriction is increased in intimal hyperplastic arteries of the XXXX .

answer: @entity0


abstract: The definition of resistant @entity3 is imprecise and variable according to the different authors. In most cases, the definition concerns @entity3 @entity0 who have received well managed treatment with optimal doses of a thymoanaleptic over a sufficiently long period of time. The distinction of @entity2 ( @entity2 ) with a rapid cycle also raises the problem of resistance to the prophylactic effect of mood regulators in @entity2 . The inefficacy of treatment in at least 20% of cases of @entity3 has led a number of authors to propose original drug combinations with the aim of potentiating the action of previous treatments. Most of the studies published report isolated cases in which the therapeutic approach is often empirical and rarely explained. The most frequently reported combination is that of 2 drugs, generally including one antidepressant. Such combinations can induce pharmacodynamic or pharmacokinetic interactions resulting in either a potentiation or a reduction of the effects of one of the 2 drugs or to the induction of @entity1 . These last two possibilities illustrate what the authors describe as "bad combinations". Various drug combinations are reviewed and critically analysed. The most interesting and best documented combinations involve the addition of @entity5 , MAOI and thyroid hormones to tricyclic treatment in non-responding @entity0 . Other combinations with tricyclics have been reported less frequently: ECT, neuroleptics, @entity9 , @entity7 , 5 HTP, @entity8 , @entity4 , @entity10 , @entity6 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Good and bad therapeutic combinations in the treatment of resistant XXXX ].

answer: @entity3


abstract: Polyclonal antibodies were prepared to the subunits of the @entity2 photosystem II fraction (PS II): p47, p43, p27, p33, p24, and p17. (The protein nomenclature refers to Mr). p47 and p43 are the subunits of reaction center complex, and p27 is light-harvesting chlorophyll protein. p33, p24, and p17 are extractable from PS II with 1 M Tris, and p24 and p17 with 1 M @entity1 . With untreated PS II fractions, the antibody to p24 inhibited the photosynthetic @entity0 -evolving activity, but not the DCPI-photoreduction activity in the presence of DPC, indicating that p24 played an important role in the former activity. Bindings of the respective antibodies to the PS II treated with @entity3 were regarded as 100%. To untreated PS II, the bindings were 20-30% for p47, p43, and p27, about 50% for p33, and 70-80% for p24 and p17. To @entity1 -washed PS II, the binding to p33 increased by 9%, indicating that p33 was adjacent or bound with p24 or/and p17. To Tris-washed PS II, the binding to p43 increased by 7%, indicating that p43 was adjacent or bound with p33. To PS II treated with 3% of @entity5 , only the binding to p27 increased appreciably. To PS II treated with 1% of @entity4 , the binding to p47 was still lower than 50%, whereas those to the other subunits were 74-91%. These values could be a measure of the extents to which the subunits were exposed to the aqueous phase, because of the nature of polyclonal antibodies. These results suggest that in intact PS II, p47, p43, and p27 were in most part buried in the inside, p47 being located at the most central and p27 at the outermost part, whereas p33, p24, and p17 were exposed to the outside by 50-75%.

title: Intermolecular relations of the photosystem II complex in XXXX chloroplasts as detected by immunochemical assay.

answer: @entity2


abstract: Recent treatment strategies have been directed toward blockade of @entity6 action or inhibition of @entity6 biosynthesis as a means of inducing regression of hormone-dependent @entity0 . The major source of @entity6 in postmenopausal @entity1 is the peripheral conversion of @entity12 to @entity9 through the enzyme aromatase. It is known that aromatase activity increases proportionately with degree of @entity3 in @entity1 . To test the importance of this modulatory factor, we correlated body weight with @entity6 excretion in our population of @entity1 with @entity0 and found significant relationships. In situ production of @entity4 from plasma precursors within @entity0 tissue may provide another source of @entity6 . Major enzymes mediating @entity6 biosynthesis were found to be present in @entity2 biopsy specimens. Aromatase activity was found to be present in 48/61 @entity1 @entity2 , sulfatase in 35/35, and @entity16 in 41/41. One inhibitor of aromatase, @entity13 , has been extensively studied in @entity1 with @entity0 . The additional effects of this drug on @entity5 side-chain cleavage and on 11-hydroxylase activity require coadministration of replacement glucocorticoid in treatment regimens. In pilot trials, 37% of @entity1 experienced objective @entity2 regression with a combination of 1000 mg @entity13 and 40 mg @entity8 daily. In randomized clinical trials with this regimen, aromatase inhibition with @entity13 produced @entity2 regression with similar frequency as did surgical hypophysectomy, surgical adrenalectomy, or @entity7 administration. The side effects of @entity13 , including lethargy, @entity10 , and @entity11 complicate its use even though these problems are generally transient. Regimens of low-dose @entity13 are being developed to reduce these side effects. Low-dose @entity13 appears to block aromatase effectively and to have limited side effects, and is undergoing extensive clinical trial. A more specific aromatase inhibitor, @entity14 , is now also being tested clinically, whereas @entity15 , another new selective inhibitor, is undergoing study in animals.

title: Inhibition of aromatase as treatment of XXXX in postmenopausal @entity1 .

answer: @entity0


abstract: Recent treatment strategies have been directed toward blockade of @entity6 action or inhibition of @entity6 biosynthesis as a means of inducing regression of hormone-dependent @entity0 . The major source of @entity6 in postmenopausal @entity1 is the peripheral conversion of @entity12 to @entity9 through the enzyme aromatase. It is known that aromatase activity increases proportionately with degree of @entity3 in @entity1 . To test the importance of this modulatory factor, we correlated body weight with @entity6 excretion in our population of @entity1 with @entity0 and found significant relationships. In situ production of @entity4 from plasma precursors within @entity0 tissue may provide another source of @entity6 . Major enzymes mediating @entity6 biosynthesis were found to be present in @entity2 biopsy specimens. Aromatase activity was found to be present in 48/61 @entity1 @entity2 , sulfatase in 35/35, and @entity16 in 41/41. One inhibitor of aromatase, @entity13 , has been extensively studied in @entity1 with @entity0 . The additional effects of this drug on @entity5 side-chain cleavage and on 11-hydroxylase activity require coadministration of replacement glucocorticoid in treatment regimens. In pilot trials, 37% of @entity1 experienced objective @entity2 regression with a combination of 1000 mg @entity13 and 40 mg @entity8 daily. In randomized clinical trials with this regimen, aromatase inhibition with @entity13 produced @entity2 regression with similar frequency as did surgical hypophysectomy, surgical adrenalectomy, or @entity7 administration. The side effects of @entity13 , including lethargy, @entity10 , and @entity11 complicate its use even though these problems are generally transient. Regimens of low-dose @entity13 are being developed to reduce these side effects. Low-dose @entity13 appears to block aromatase effectively and to have limited side effects, and is undergoing extensive clinical trial. A more specific aromatase inhibitor, @entity14 , is now also being tested clinically, whereas @entity15 , another new selective inhibitor, is undergoing study in animals.

title: Inhibition of aromatase as treatment of @entity0 in postmenopausal XXXX .

answer: @entity1


abstract: Head-out immersion of @entity0 in cold water concurrently stimulates low-pressure receptors and cutaneous cold receptors. In theory, the low-pressure receptors inhibit sympathetic nerve activity to the extent of modifying plasma @entity2 responses to chilling of the skin. @entity0 plasma @entity2 concentrations ([NE]p's) were measured when low-pressure receptors were stimulated by 6 h of head-out immersion in thermoneutral water (35 degrees C). The experimental protocol was repeated when cold receptors were activated by a separate exposure to 14.8 degrees C air. Furthermore, both types of receptors were activated by 6 h of immersion in cold water (29.8 degrees C). The control exposure maintained [NE]p close to a constant value of 0.34 ng/ml. Thermoneutral water reduced [NE]p to 0.18 ng/ml after 30 min of immersion, but the change was not statistically significant (two-way ANOVA). [NE]p increased to peak values of 1.5 ng/ml in cold air (P less than 0.05) and 1.1 ng/ml in cold water (P less than 0.5), with no significant differences observed between [NE]p's in cold air and cold water. Equal rates of body @entity1 occurred during the exposures to cold air and cold water. Since [NE]p's were comparably raised by separate exposures to cold water and cold air, stimulation of low-pressure receptors by immersion did not significantly depress peripheral vasomotor nerve activity during head-out immersion in cold water.

title: Effect of hydrostatic pressure on plasma concentrations of XXXX during cold water immersion.

answer: @entity2


abstract: Multiplanar images of 62 pelvic lesions in 58 @entity0 and adolescents (aged 7 months to 19 years; mean, 10.6 years) were obtained with 0.3-T magnetic resonance (MR) imaging. Lesions were divided into three categories: @entity2 , @entity4 and fluid collections, and @entity1 . MR demonstrated lesions well in all categories. Midline lesions were best imaged sagittally, and lesions of paired structures, axially. The coronal plane was useful in evaluating the superoinferior extent of lesions and in defining the extent of @entity3 . T1-weighted sequences were sufficient to depict most congenital and @entity4 . T2-weighted sequences were useful in demonstrating the extent of @entity1 and the position of ectopic gonads. Ultrasonography (US) was also performed in 45 cases. MR and US delineated lesions equally well in 25 cases (55.5%), MR was superior in 19 (42.4%), and US was superior in one (2.2%). Computed tomography (CT) was performed in 13 cases. MR and CT delineated lesions equally well in eight cases (61.5%), MR was superior in four (30.8%), and CT was superior in one (7.7%).

title: Pelvic abnormalities in XXXX : assessment with MR imaging.

answer: @entity0


abstract: OBJECTIVE: Analyzing the results and validating the procedure of testicular sperm extraction (TESE) performed on the day of oocyte retrieval in non obstructive @entity1 (NOA) @entity0 . @entity0 AND METHODS: Sixty TESE were performed on the day of oocyte retrieval ( @entity2 ), in 52  NOA @entity0 . @entity0 were sorted into three groups according to the results of the surgical procedure: 1: sperm recovery with possible sperm freezing (n=20); 2: sperm recovery without freezing (n=27); 3: "negative" biopsy (n=13). ICSI outcomes in the two groups with sperm recovery were compared to those of ICSI performed with frozen-thawed sperm obtained from TESE performed (n=13). RESULTS: The rate of positive sperm retrieval was 78%. While the overall clinical pregnancy rate was 50%, no difference in the fertilization, implantation and clinical pregnancy rates was found in the two groups with positive sperm retrieval as compared to frozen-thawed sperm group. Twelve pregnancies were obtained in @entity0 without further sperm cryopreservation. CONCLUSION: After TESE in NOA @entity0 , cryopreserved sperm produced comparable results with freshly obtained sperm. However, TESE performed on @entity2 can offer the opportunity, in @entity0 with rare sperm that might not survive freeze-thaw, to have a possible fresh embryo transfer. Couples should be counselled regarding the possibility of oocyte retrieval without sperm for ICSI.

title: [Non-obstructive XXXX : option of the testicular sperm extraction performed on the day of oocyte retrieval].

answer: @entity1


abstract: BACKGROUND: Rotational atherectomy followed by drug-eluting stent (DES) implantation for complex, severely @entity3 is a rational combination that has not been sufficiently evaluated. METHODS: We investigated 102 consecutive @entity0 with angiographic evidence of heavily @entity3 that underwent DES implantation following rotational atherectomy at our institution between June 2005 and October 2009, and we examined the long-term clinical outcomes. The major adverse @entity5 monitored were @entity4 , @entity7 and @entity3 revascularization. RESULTS: @entity0 were 68.8    7.4 years old, 52.9% were @entity1 , and 12.7% had @entity9 . Forty-seven @entity0 (46.1%) had @entity2 , and 13 (12.7%) had left main @entity10 . The radial approach was used in 37.3% of cases. The procedure was successful in 97%. In-hospital @entity4 occurred in 1 @entity0 (0.9%), and 3 @entity0 (2.9%) developed stent @entity8 . At the mean follow-up period of 15 months (range 1- 54), the total @entity4 rate was 4.9%, @entity3 revascularization was 8.8% and the incidence of @entity7 was 3.9%. The combined endpoint occurred in 12.7% of cases. CONCLUSION: DES following rotational atherectomy for heavily calcified @entity6 is a safe and effective procedure that provides good long-term clinical outcomes.

title: Drug-eluting stents following rotational atherectomy for heavily calcified XXXX : long-term clinical outcomes.

answer: @entity6


abstract: These experiments were performed to determine whether the neurotransmitters @entity3 ( @entity4 ) and vasoactive intestinal peptide ( @entity6 ) increase cerebral blood flow (CBF). In anesthetized @entity2 , infusion of very large doses of @entity4 (500 microgram/min) into the carotid artery increased CBF (measured with microspheres) 50%. Anatomical limitations prevented adequate testing of cerebrovascular responses in @entity2 . In anesthetized @entity1 , infusion of @entity4 (10 microgram/min) into the carotid artery produced a twofold increase in CBF. Vessels in gray matter were more responsive than vessels in white matter. @entity4 did not alter cerebral @entity0 consumption, which indicates that the dilator effect of the drug is not an indirect effect mediated through an increase in metabolism. The vasodilator response to @entity4 was attenuated by @entity5 (1 mg iv). Intracarotid infusion of @entity6 in @entity1 increased blood flow to cerebral gray matter: infusion of @entity6 (10 microgram/min) incresed flow 33%. We conclude that 1) cerebral vasodilator responses to @entity4 and @entity6 are larger than previously recognized and 2) responses to these drugs occur primarily in cerebral gray matter. Because the neurotransmitters increase CBF significantly, these studies should encourage further studies concerning effects of cholinergic and peptidergic nerves on cerebral vessels.

title: Effect of XXXX and vasoactive intestinal peptide on cerebral blood flow.

answer: @entity3


abstract: Evidence points to the efficacy of physical and occupational therapy intervention for the management of @entity2 related to the treatment of @entity0 . However, few studies give voice to the @entity1 participating in the physical rehabilitation programs intended to ameliorate their deficits. OBJECTIVE: The purpose of this qualitative investigation was to explore the experience of physical rehabilitation as well as to identify recommendations for physical and occupational therapy practice from the perspective of the client undergoing therapy for @entity0 . DESIGN: A phenomenological design was chosen and included a purposive sample of @entity1 (n = 10) undergoing physical rehabilitation for impairments related to @entity0 treatment. Data included semistructured interviews and artifact examination. METHODS: Ten semistructured interviews were conducted at a setting of the @entity1 ' choice. Data collection continued until saturation was reached. Data analysis was cyclical and ongoing and involved all six researchers in analyzing and triangulating all pieces of data. Member checks and a peer review were conducted to confirm relevance and validity. RESULTS: Five themes emerged: 1) challenges with obtaining referrals, 2) challenges with @entity1 education, 3) improvements in functional impairments, 4) emotional support, and 5) benefits of a specialized clinic environment. CONCLUSIONS: Consideration of the five themes led to four recommendations for physical and occupational therapist practice from the perspective of the client: 1) advocate for presurgical therapy consultations, 2) be competent in the management of all @entity2 associated with @entity0 treatment, 3) be aware of the emotional support the therapist has the capacity to provide or not provide, and 4) as much as possible, create an inviting, nonclinical environment.

title: Recommendations for physical and occupational therapy practice from the perspective of clients undergoing therapy for XXXX .

answer: @entity0