abstract: UNASSIGNED: ABSTRACT Aim: In locally @entity2 with bowel involvement appropriate surgical treatment is still controversial. Objective was to delineate factors to select those most likely to benefit from radical surgery in @entity0 with locally @entity2 . Methods: Therefore, we retrospectively evaluated 207 consecutive @entity0 with primary @entity2 who underwent primary surgery between 2000 and 2007. Every @entity0 received stage-related surgery and adjuvant @entity3 -based chemotherapy. Median follow-up was 53.5 months. Data collected included stage, histology, extent of cytoreduction and type of bowel resection. Univariate survival analyses were performed to investigate variables associated with outcome. Results: Optimal cytoreduction (OCR) (R  <= 1  cm) was achieved in 76.8%. Most @entity0 presented histologic grade 2/3 (96.6%), @entity2 (84.1%) and lymph node involvement (52.2%). Complete cytoreduction (R = 0  mm) has significant best prognostic impact in FIGO IIB-IV (p = .026). Regarding bowel involvement, bowel resection was performed in 82 @entity0 (39.6%). In this subgroup of @entity0 complete cytoreduction led to significant better overall survival than R > 0  mm-1  cm, even in FIGO IIIC-IV @entity0 (p = .027); this fact is independent of bowel resection. Noticeably, for survival bowel resection achieving @entity1 mass below 1  cm was also one main prognostic factor and even recurrence rate was associated with @entity1 mass. Conclusion: Our findings suggest that the major prognostic factor in @entity0 with @entity2 needing colorectal resection is completeness of cytoreduction. Therefore, in @entity2 @entity0 , multivisceral surgery is indicated to achieve OCR (R  <= 1  cm) with or without bowel resection with best prognostic impact.

title: The Prognostic Role of Optimal Cytoreduction in Advanced, Bowel Infiltrating XXXX .

answer: @entity2


abstract: The effects of timing of a single daily meal on the circadian rhythm of blood @entity1 clearance rates were investigated in two groups of @entity0 maintained on opposite 12 hours light: 12 hours dark (LD) schedules. Initially, the @entity0 were fed ad libitum. Then feeding was restricted to 4 mid-light (ML) hours for one group and 4 @entity2 ( @entity2 ) hours for the other. Finally, the meal timing was reversed; the ML-fed group became the @entity2 -fed group and vice versa. Following acclimatization to each of the 3 feeding regimens, blood @entity1 clearance @entity0 ere determined for subgroups (n - 8) of both groups injected (i.p.) with @entity1 at 5 times during 24-hour spans. The LD schedule synchronized the clearance rate rhythm during ad libitum feeding. Although the rhythm persisted without significant amplitude changes during restricted feeding regimens, minimal clearance rates during ML and @entity2 feeding approximately the time of food presentation, with maximal rates 8-12 hours later. This relationship remained constant with the feeding phases were reversed. Thus, when food availability is limited, the single daily mean dominates the lighting regimen as synchronizer of the circadian blood @entity1 clearance rate rhythm.

title: Meal timing dominates the lighting regimen as a synchronizer of the circadian blood XXXX clearance rate rhythm in @entity0 .

answer: @entity1


abstract: The effects of timing of a single daily meal on the circadian rhythm of blood @entity1 clearance rates were investigated in two groups of @entity0 maintained on opposite 12 hours light: 12 hours dark (LD) schedules. Initially, the @entity0 were fed ad libitum. Then feeding was restricted to 4 mid-light (ML) hours for one group and 4 @entity2 ( @entity2 ) hours for the other. Finally, the meal timing was reversed; the ML-fed group became the @entity2 -fed group and vice versa. Following acclimatization to each of the 3 feeding regimens, blood @entity1 clearance @entity0 ere determined for subgroups (n - 8) of both groups injected (i.p.) with @entity1 at 5 times during 24-hour spans. The LD schedule synchronized the clearance rate rhythm during ad libitum feeding. Although the rhythm persisted without significant amplitude changes during restricted feeding regimens, minimal clearance rates during ML and @entity2 feeding approximately the time of food presentation, with maximal rates 8-12 hours later. This relationship remained constant with the feeding phases were reversed. Thus, when food availability is limited, the single daily mean dominates the lighting regimen as synchronizer of the circadian blood @entity1 clearance rate rhythm.

title: Meal timing dominates the lighting regimen as a synchronizer of the circadian blood @entity1 clearance rate rhythm in XXXX .

answer: @entity0


abstract: The karyotypes of a Puerto Rican strain of @entity0 and a Kenyan strain of S. rodhaini are similar in number of general morphology. For each species there are eight pairs of chromosomes (2n =16) which are divided into three size groups. C-banded methods revealed, in addition to centromeric heterochromatin, a large @entity2 in one for the No. 2 chromosomes in females but not in the other. Neither No. 2 chromosome of males possessed the @entity2 . This pair (2) is interpreted as the sex chromosomes, with the female being heterogametic (ZW), the male homogametic (ZZ). Differences between karyotypes of the two species occurred. These included a satellite on the No. 3 chromosome of @entity1 and a euchromatic tip on the otherwise heterochromatic short arm of the W chromosome of this species; neither of these was present in S. rodhaini. The two species also differed in that the centromeric index of the Z of @entity1 was smaller than that of the W, whereas in S rodhaini the reverse was true. In @entity1 the large @entity2 of the W chromosome was identified in prophase and interphase nuclei as well as at metaphase.

title: Conventional giemsa and C-banded karyotypes of XXXX and S. rodhaini.

answer: @entity0


abstract: BACKGROUND: Laparoscopic resection for transverse @entity3 remains controversial. The aim of this study is to investigate the short- and long-term outcomes of laparoscopic surgery for transverse @entity3 . METHODS: A total of 278 @entity0 with transverse @entity3 from a single institution were included. All @entity0 underwent curative surgery, 156 @entity0 underwent laparoscopic resection (LR), and 122 @entity0 underwent open resection (OR). The short- and long-term results were compared between two groups. RESULTS: Baseline demographic and clinical characteristics were comparable between two groups. Conversions were required in eight (5.1  %) @entity0 . LR group was associated with significantly longer median operating time (180 vs. 140  min; P   <   0.001). Median estimated @entity2 was significantly less in LR group (90 vs. 100  ml; P   =   0.001). Time to first flatus and oral intake was significantly earlier in LR group. Perioperative mortality and morbidity rate were not significantly different between two groups. @entity1 size, number of lymph nodes harvested, length of proximal, and distal resection margin were comparable between two groups. Postoperative hospital stay was significantly shorter in LR group (9 vs. 10d; P   <   0.001). Five-year disease-free survival and overall survival rate were similar between two groups. CONCLUSIONS: Laparoscopic resection for transverse @entity3 is associated with better short-term outcomes and equivalent long-term oncologic outcomes.

title: Outcome of Laparoscopic Versus Open Resection for Transverse XXXX .

answer: @entity3


abstract: OBJECTIVE: The objective of this study was to report the long-term outcomes of cooled radiofrequency (CRF) @entity4 ( @entity4 ) as a treatment for sacroiliac (SI) region @entity1 . Whereas the 1-, 3-, 6-, and 9-month outcomes of this procedure compared to sham treatment were previously reported, this current report shows the 12-month outcomes of CRF/ @entity4 treatment for SI region @entity1 . DESIGN: This study originally included 51 subjects who were randomized 2:1 to receive CRF/ @entity4 treatment or a sham intervention, respectively, for SI region @entity1 . Subjects and assessors were blinded for 3  months. At that time, sham @entity0 were permitted to receive CRF/ @entity4 , designated as "crossover" study subjects, and followed for 6 additional months. For the purpose of this evaluation, the original CRF/ @entity4 -treated study subjects were followed for a total of 12  months. Study @entity0 were 18 to 88  years of age and had chronic (symptomatic for >6  months) @entity2 . All subjects were qualified for study inclusion following positive responses to dual lateral branch blocks. @entity4 was performed by CRF to ablate the S1 to S3 lateral branches and the L5 dorsal ramus. @entity1 was measured by a numerical rating scale (NRS) and Short Form 36-bodily @entity1 (SF36-BP) scores. The @entity3 index and Short Form 36-physical functioning (SF36-PF) assessment each served to evaluate subject disability. Treatment successes ("responders") in the originally treated CRF/ @entity4 group at 12  months, and in the crossover group at 6  months, were also determined. RESULTS: In the original CRF/ @entity4 treatment group, 12-month outcomes compared to baseline were favorable, with a mean 2.7 point drop in the NRS score, a 13.9 decrease in the ODI, and a 15.8 increase in SF-36BP. In the crossover study group, 6-month outcomes were also favorable, with a mean NRS score decrease of 2.5 points, a reduction in ODI of 8.8, and an increase in SF36-BP of 11.9. CONCLUSIONS: These favorable 12-month results illustrate the durability of effective CRF/ @entity4 -mediated treatment of SI region @entity1 for selected @entity0 . Furthermore, successful CRF/ @entity4 treatments in unblinded crossover study subjects demonstrate the unlikelihood that such positive outcomes are attributable to a "placebo" effect, and suggest that CRF/ @entity4 is an effective therapeutic option for alleviating @entity1 , and improving physical function and quality of life, with few complications.

title: Twelve-Month Follow-Up of a Randomized Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Region XXXX .

answer: @entity1


abstract: UNASSIGNED: Owing to applications in the food and nutraceutical industries, inulinases, fructosyltransferases and sucrases have gained considerable attention in recent times. Twenty-five fungal strains were screened for production of these enzymes on three different media formulated using inulin-rich plant extracts prepared from asparagus root, dahlia tuber and dandelion root extract. Culture filtrates of the fungi were examined for hydrolytic activities. Fungi belonging to genus Aspergillus, A. @entity1 GNCC 2655 (11.3  U/ml), A. awamori MTCC 2879 (8.2  U/ml), A. @entity1 ATCC 26011 (7.9  U/ml) secreted high titers of inulinase followed by Penicillium sp. NFCCI 2768 (2.6  U/ml) and Penicillium citrinum MTCC 1256 (1.1  U/ml). High sucrase activity was noticed in A. @entity1 GNCC 2613 (113  U/ml) and A. awamori MTCC 2879 (107.8  U/ml). Analysis of end products of inulinase action by HPLC revealed that most of the enzymes were exo-inulinases liberating @entity0 exclusively from inulin. Five fungi, P. citrinum MTCC 1256, Penicillium rugulosum MTCC 3487, Penicillium sp. NFCCI 2768, A. fumigatus GNCC 1351 and A. @entity1 ATCC 26011 however, produced a mixture of endo- and exo-inulinases liberating oligosaccharides (GF3 and GF2) along with @entity0 . High inulinase/sucrase yielding strains were evaluated for extracellular and intracellular hydrolytic and transfructosylating activities and intracellular enzyme profiles were found to be considerably different in terms of titers and end products.

title: Production of inulinase, fructosyltransferase and sucrase from fungi on low-value inulin-rich substrates and their use in generation of XXXX and fructo-oligosaccharides.

answer: @entity0


abstract: UNASSIGNED: Abstract Objectives: Exploratory pilot study to determine the correlation between @entity7 and vaginal cytokine levels. Methods: Postmenopausal @entity0 (n   =   34) not using menopausal hormone therapy and presenting with or without symptoms of @entity1 were screened. Each @entity0 underwent a vaginal examination and screening for @entity5 . A cervicovaginal lavage (CVL) with sterile saline and a peripheral blood sample were obtained. Main outcome measures were assessed by Luminex   X-map method on the Bio-Plex   platform. Main outcome measures were cervicovaginal and serum @entity9 , @entity3 , @entity6 , IL-12, @entity10 , @entity4 , @entity8 , @entity12 and @entity11 level. Cervicovaginale cytokines were adjusted to total protein concentration [pg/mcg protein]. Results: Twenty-six postmenopausal @entity0 were enrolled (symptomatic: n   =   15; asymptomatic: n   =   11). There were no significant differences between groups: age, age at menopause, vaginal pH and all CVL and serum cytokines ( @entity9 , @entity3 , @entity6 , IL-12, @entity10 , @entity4 , @entity8 , @entity12 and @entity11 ). @entity8 was the most abundant vaginal cytokine (symptomatic: 146.5        165.6   pg/mcg protein; asymptomatic: 146.0        173.5   pg/mcg protein; p   =   0.99). Conclusions: Postmenopausal vulvovaginal symptoms did not correlate with vaginal inflammatory marker. There was no difference in serum or CVL cytokines between symptomatic and asymptomatic postmenopasual @entity0 . Vaginal symptoms after menopause are not related to the vaginal cytokine changes associated with loss of @entity2 .

title: Vaginal cytokines do not correlate with XXXX .

answer: @entity7


abstract: OBJECTIVE: To compare the clinical effect of graciloplasty using two different gracilis encircled loops and to research the better method for the treatment of @entity3 after anoplasty for imperforate anus. METHODS: Clinical data of 38 @entity1 @entity0 with @entity2 undergoing graciloplasty in our hospitals from January 2009 to January 2012 were retrospectively analyzed. Twenty @entity0 received the modified surgery in which the gracilis muscle was transposed anticlockwise into a circum-anal tunnel with a U-loop and its tendon secured to the ipsilateral pectineal ligament. Eighteen @entity0 received the traditional surgery in which the gracilis muscle was wrapped clockwise around the anus with a y-loop and its tendon secured to the contralateral periosteum of ischial tuberosity or pectineal ligament. All the @entity0 were evaluated via Wexner score and anal manometry before surgery and 2 weeks, 6 months, 1 year and 2 years after surgery. In addition, it was assessed whether the @entity0 had difficulty defecating while squatting after surgery. RESULTS: Generalized estimating equations showed that the Wexner score in two groups gradually decreased after surgery(P=0.000), but there was no significant difference between two groups(P=0.554). At 2 weeks, 6 months, 1 year and 2 years after surgery, there were respectively 4 cases(20.0%), 3 cases(15.0%), 2 cases(10.0%), 1 case(5.0%), who showed squatting difficult defecation in the U-loop group, and 10 cases(55.6%), 12 cases(66.7%), 10 cases(55.6%), 8 cases(44.4%) in the y-loop group. The probability of squatting difficult defecation in U-loop group was significantly lower compared to y-loop group(P=0.002), but the probability of squatting difficult defecation in two groups did not obviously change with time(P=0.057). Repeated measures ANOVA showed that anal resting pressure, anal maximal squeeze pressure, duration of anal squeeze, and rectal maximum tolerable volume in two groups were gradually improved after surgery (all P<0.01), but there were no significant differences between two groups(all P>0.05). CONCLUSIONS: Graciloplasty with different gracilis loops can improve anal function. However, U-loop can better improve difficult defecating while squatting, and is worthwhile for spreading in clinical practice.

title: [Effects of different gracilis loops in graciloplasty on XXXX ].

answer: @entity3


abstract: OBJECTIVE: The role of Gamma knife radiosurgery (GKS) after the resection of brain metastases remains undefined. We evaluated the outcomes of postoperative GKS to the @entity2 bed after the resection of brain @entity1 compared with GKS alone without resection in the same @entity0 . METHODS: We performed a retrospective review of 24 @entity0 who underwent GKS to the @entity2 bed after the resection of brain metastases. In this cohort, 25 metastatic lesions were treated with postoperative GKS, and 37 brain metastatic lesions were simultaneously managed with GKS alone without resection. RESULTS: The median target volume and marginal dose of GKS to the surgical bed were 10.5 cm(3) and 15.0 Gy, respectively. The median target volume and marginal dose of GKS alone for the metastatic lesions were 0.5 cm(3) and 21.0 Gy, respectively. The actuarial 1-year and 2-year overall survival of the @entity0 were 43.1% and 28.7%, respectively. The median overall survival of all @entity0 was 11 months. The actuarial 6-month and 12-month local progression-free survival of GKS alone for metastatic lesions without resection were 92.6% and 84.9%; however, the actuarial 6-month and 12-month local progression-free survival of GKS to the surgical bed were 82% and 71%, respectively. CONCLUSIONS: For @entity0 with brain metastases treated with surgical resection, postoperative GKS to the resection area is an effective and safe treatment option. Particularly, concurrent postoperative GKS to the surgical cavity with GKS alone for multiple small metastatic lesions is a feasible treatment strategy for multiple brain metastases.

title: Effectiveness of Postoperative Gamma Knife Radiosurgery to the Tumor Bed After Resection of Brain XXXX .

answer: @entity1


abstract: BACKGROUND: To summarize data on long-term ipsilateral local recurrence (LR) and @entity0 death rate (BCDR) for @entity1 with @entity4 ( @entity4 ) who received different treatments. METHODS: Systematic review and study-level meta-analysis of prospective (n   =   5) and retrospective (n   =   21) studies of @entity1 with pure @entity4 and with median or mean follow-up time of >= 10  years. Meta-regression was performed to assess and adjust for effects of potential confounders - the average age of @entity1 , period of initial treatment, and of bias - follow-up duration on recurrence- and death-rates in each treatment group. LR and BCDR rates by local treatment used were reported. Outside of randomized trials, remaining studies were likely to have tailored @entity1 treatment according to the clinical situation. RESULTS: Nine thousand four hundred and four @entity4 cases in 9391 @entity1 with 10-year follow-up were included. The adjusted meta-regression LR rate for mastectomy was 2.6  % (95 % CI, 0.8-4.5); breast-conserving surgery with radiotherapy (RT), 13.6  % (95 % CI, 9.8-17.4); breast-conserving surgery without RT, 25.5  % (95 % CI, 18.1-32.9); and biopsy-only (residual predominately low-grade @entity4 following inadequate excision), 27.8  % (95 % CI, 8.4-47.1). RT   +   @entity3 ( @entity5 ) in conservation surgery (CS) @entity1 resulted in lower LR compared to one or no adjuvant treatments: LR rate for CS   +   RT   +   @entity5 , 9.7  %; CS   +   RT(no @entity5 ), 14.1  %; CS   +   @entity5 (no RT), 24.7  %; CS(alone), 25.1  % (linear trend for treatment P   <   0.0001). Compared to CS   +   RT   +   @entity5 , a significantly higher invasive LR was observed for CS(alone), odds ratio (OR) 2.61 (P   <   0.0001); CS   +   @entity5 (no RT), OR 2.52 (P   =   0.001); CS   +   RT(no @entity5 ), OR 1.59 (P   =   0.022). BCDR was similar for mastectomy, breast-conserving surgery with or without RT (1.3-2.0  %) and non-significantly higher for biopsy-only (2.7  %). Additionally, the 15-year follow-up was reported where all like-studies had   >=    15-year data sets; the biopsy-only @entity1 had a meta-analysed total LR rate of 40.2  % and the invasive LR rate was 28.1  %. The biopsy-only @entity1 had a   >=    15-year BCDR (that included @entity1 with @entity2 ) of 17.9  %; the   >=    15-year BCDR was 55.2  % for those with invasive LR. CONCLUSIONS: More local intervention was associated with greater local control for @entity1 with @entity4 at long-term follow-up. For @entity1 undergoing breast-conservation, invasive LR was significantly lower when two rather than one adjuvant treatment modalities were given.

title: Long-term outcomes of XXXX of the breast: a systematic review, meta-analysis and meta-regression analysis.

answer: @entity4


abstract: BACKGROUND: The development of long-term @entity1 can be linked to the intrauterine environment, and maternal nutrition during gestation plays a critical role in the future vascular health of offspring. The purpose of this investigation was to test the hypothesis that a high-energy (HE) gestational diet, HE post-weaning diet, or their combination will lead to @entity0 in offspring. METHODS: Duroc * Landrace gilts (n   =   16) were assigned to either a HE (10,144 Kcal/day, n   =   8) or normal energy (NE: 6721 Kcal/day, n   =   8) diet throughout pregnancy. Piglets were placed on either a NE or HE diet during the growth phase. At 3  months of age femoral arteries were harvested from offspring (n   =   47). Endothelial-dependent and -independent vasorelaxation was measured utilizing wire-myography and increasing concentrations of bradykinin (BK) and sodium nitroprusside (SNP), respectively. RESULTS: BK and SNP induced vasorelaxation were significantly reduced in the femoral arteries of gestational HE offspring. However, no effect for the post-weaning diet on BK and SNP induced vasorelaxation was seen. This investigation demonstrates that a HE diet prenatally diminishes both BK and SNP induced vasorelaxation in @entity3 . CONCLUSIONS: These findings suggest that a HE gestational diet can play a critical role in the development of offspring's vascular function, predisposing them to @entity0 . This dysfunction may lead to @entity2 development later in life.

title: Impact of excess gestational and post-weaning energy intake on vascular function of XXXX offspring.

answer: @entity3


abstract: OBJECTIVE: Assess reported risk of suicide attempts by @entity0 with @entity1 ( @entity2 ). METHOD: Systematic searching yielded 101 reports from 22 countries (79  937 subjects). We analyzed for risk (%) and incidence rates (%/year) of attempts, comparing sex and diagnostic types, including by meta-analysis. RESULTS: Attempt risk averaged 31.1% [CI: 27.9-34.3] of subjects, or 4.24 [3.78-4.70]%/year. In @entity2 -I (43 studies) and @entity2 subjects (30 studies), risks (29.9%, 31.4%) and incidence rates (4.01, 4.11%/year) were similar and not different by meta-analysis. Among @entity0 vs. @entity0 , risks (33.7% vs. 25.5%) and incidence (4.50 vs. 3.21%/year) were greater (also supported by meta-analysis: RR  =  1.35 [CI: 1.25-1.45], P  <  0.0001). Neither measure was related to reporting year, % @entity0 /study, or to onset or current age. Risks were greater with longer exposure, whereas incidence rates decreased with longer time at risk, possibly through 'dilution' by longer exposure. CONCLUSION: This systematic update of international experience underscores high risks of suicide attempts among @entity0 with @entity2 ( @entity2 -I  =  @entity2 ; @entity0  >  @entity0 ). Future studies should routinely include exposure times and incidence rates by diagnostic type and sex for those who attempt suicide or not.

title: Suicide attempts in XXXX : comprehensive review of 101 reports.

answer: @entity1


abstract: PURPOSE: Based on a nation-wide database, this study analysed the influence of @entity3 ( @entity6 ), @entity5 inhibitors and a combination of the two on @entity4 occurrence in JIA @entity0 . METHODS: Data from the National Paediatric Rheumatological Database in Germany were used in this study. Between 2002 and 2013, data from JIA @entity0 were annually documented at the participating paediatric rheumatological sites. @entity0 with @entity1 duration of less than 12 months at initial documentation and >= 2 years of follow-up were included in this study. The impact of anti-inflammatory treatment on the occurrence of @entity4 was evaluated by discrete-time survival analysis. RESULTS: A total of 3,512 JIA @entity0 (mean age 8.3  4.8 years, female 65.7%, ANA-positive 53.2%, mean age at @entity2 onset 7.8  4.8 years) fulfilled the inclusion criteria. Mean total follow-up time was 3.6  2.4 years. @entity4 developed in a total of 180 @entity0 (5.1%) within one year after @entity2 onset. @entity4 onset after the first year was observed in another 251 @entity0 (7.1%). DMARD treatment in the year before @entity4 onset significantly reduced the risk for @entity4 : @entity6 (HR 0.63, p=0.022), @entity5 inhibitors (HR 0.56, p<0.001) and a combination of the two (HR 0.10, p<0.001). @entity0 treated with @entity6 within the first year of JIA had an even a lower @entity4 risk (HR 0.29, p<0.001). CONCLUSION: The use of DMARDs in JIA @entity0 significantly reduced the risk for @entity4 onset. Early @entity6 use within the first year of disease and the combination of @entity6 with a @entity5 inhibitor had the highest protective effect. This article is protected by copyright. All rights reserved.

title: Impact of anti-inflammatory treatment on the onset of XXXX in juvenile idiopathic arthritis: Longitudinal analysis from a nation-wide paediatric rheumatological database.

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a serious disease. The gut microbiota has recently been identified as a new potential risk factor in addition to well-known @entity1 risk factors. To investigate the gut microbiota composition in association with the dietary patterns in @entity0 with different @entity2 tolerance we analyzed 92 @entity0 : with normal @entity2 tolerance (n=48), @entity6 ( @entity6 , n=24), @entity4 (n=20). Metagenomic analysis was performed using 16SrRNA sequencing. The diet has been studied by a frequency method with a quantitative evaluation of food intake using a computer program. Microbiota in the samples was predominantly represented by Firmicutes, in a less degree by Bacteroidetes. Blautia was a dominanting genus in all samples. The representation of Blautia, @entity7 was lower in @entity6 than in @entity4 @entity0 , and even lower in those with normal @entity2 tolerance. After the clustering of the samples into groups according to the percentage of protein, fat, @entity5 in the diet, the representation of the Bacteroides turned to be lower and Prevotella abundance turned to be higher in @entity3 cluster. There were more @entity0 with insulin resistance, @entity4 in the fat-protein cluster. Using the Calinski-Harabasz index identified the samples with more similar diets. It was discovered that half of the @entity0 with a high-fat diet had normal tolerance, the others had @entity4 . The regression analysis showed that these @entity4 @entity0 also had a higher representation of Blautia. Our study provides the further evidence concerning the structural modulation of the gut microbiota in the T2DM pathogenesis depending on the dietary patterns.

title: Gut microbiota and diet in @entity0 with different XXXX tolerance.

answer: @entity2


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a serious disease. The gut microbiota has recently been identified as a new potential risk factor in addition to well-known @entity1 risk factors. To investigate the gut microbiota composition in association with the dietary patterns in @entity0 with different @entity2 tolerance we analyzed 92 @entity0 : with normal @entity2 tolerance (n=48), @entity6 ( @entity6 , n=24), @entity4 (n=20). Metagenomic analysis was performed using 16SrRNA sequencing. The diet has been studied by a frequency method with a quantitative evaluation of food intake using a computer program. Microbiota in the samples was predominantly represented by Firmicutes, in a less degree by Bacteroidetes. Blautia was a dominanting genus in all samples. The representation of Blautia, @entity7 was lower in @entity6 than in @entity4 @entity0 , and even lower in those with normal @entity2 tolerance. After the clustering of the samples into groups according to the percentage of protein, fat, @entity5 in the diet, the representation of the Bacteroides turned to be lower and Prevotella abundance turned to be higher in @entity3 cluster. There were more @entity0 with insulin resistance, @entity4 in the fat-protein cluster. Using the Calinski-Harabasz index identified the samples with more similar diets. It was discovered that half of the @entity0 with a high-fat diet had normal tolerance, the others had @entity4 . The regression analysis showed that these @entity4 @entity0 also had a higher representation of Blautia. Our study provides the further evidence concerning the structural modulation of the gut microbiota in the T2DM pathogenesis depending on the dietary patterns.

title: Gut microbiota and diet in XXXX with different @entity2 tolerance.

answer: @entity0


abstract: UNASSIGNED: @entity2 ( @entity9 ) is naturally produced in the body and stored in muscles where it is involved in energy generation. It is widely used, especially by athletes, as a staple supplement for improving physical performance. Recent reports have shown that @entity9 displays antioxidant activity which could explain its beneficial cellular effects. We have evaluated the ability of @entity9 to protect @entity0 erythrocytes and lymphocytes against oxidative damage. Erythrocytes were challenged with model oxidants, @entity10 (AAPH) and @entity1 ( @entity7 ) in the presence and absence of @entity9 . Incubation of erythrocytes with oxidant alone increased @entity5 , @entity6 levels, lipid peroxidation and protein @entity8 content. This was accompanied by decrease in @entity4 levels. Antioxidant enzymes and antioxidant power of the cell were compromised while the activity of membrane bound enzyme was lowered. This suggests induction of oxidative stress in erythrocytes by AAPH and @entity7 . However, @entity9 protected the erythrocytes by ameliorating the AAPH and @entity7 induced changes in these parameters. This protective effect was confirmed by electron microscopic analysis which showed that oxidant-induced cell damage was attenuated by @entity9 . No cellular alterations were induced by @entity9 alone even at 20 mM, the highest concentration used. @entity3 , a by-product of @entity9 metabolism, was also shown to exert protective effects, although it was slightly less effective than @entity9 . @entity0 lymphocytes were similarly treated with @entity7 in absence and presence of different concentrations of @entity9 . Lymphocytes incubated with oxidant alone had alterations in various biochemical and antioxidant parameters including decrease in cell viability and induction of DNA damage. The presence of @entity9 attenuated all these @entity7 -induced changes in lymphocytes. Thus, @entity9 can function as a blood antioxidant, protecting cells from oxidative damage, genotoxicity and can potentially increase their lifespan.

title: Diminution of Oxidative Damage to @entity0 Erythrocytes and Lymphocytes by XXXX : Possible Role of @entity2 in Blood.

answer: @entity2


abstract: UNASSIGNED: @entity2 ( @entity9 ) is naturally produced in the body and stored in muscles where it is involved in energy generation. It is widely used, especially by athletes, as a staple supplement for improving physical performance. Recent reports have shown that @entity9 displays antioxidant activity which could explain its beneficial cellular effects. We have evaluated the ability of @entity9 to protect @entity0 erythrocytes and lymphocytes against oxidative damage. Erythrocytes were challenged with model oxidants, @entity10 (AAPH) and @entity1 ( @entity7 ) in the presence and absence of @entity9 . Incubation of erythrocytes with oxidant alone increased @entity5 , @entity6 levels, lipid peroxidation and protein @entity8 content. This was accompanied by decrease in @entity4 levels. Antioxidant enzymes and antioxidant power of the cell were compromised while the activity of membrane bound enzyme was lowered. This suggests induction of oxidative stress in erythrocytes by AAPH and @entity7 . However, @entity9 protected the erythrocytes by ameliorating the AAPH and @entity7 induced changes in these parameters. This protective effect was confirmed by electron microscopic analysis which showed that oxidant-induced cell damage was attenuated by @entity9 . No cellular alterations were induced by @entity9 alone even at 20 mM, the highest concentration used. @entity3 , a by-product of @entity9 metabolism, was also shown to exert protective effects, although it was slightly less effective than @entity9 . @entity0 lymphocytes were similarly treated with @entity7 in absence and presence of different concentrations of @entity9 . Lymphocytes incubated with oxidant alone had alterations in various biochemical and antioxidant parameters including decrease in cell viability and induction of DNA damage. The presence of @entity9 attenuated all these @entity7 -induced changes in lymphocytes. Thus, @entity9 can function as a blood antioxidant, protecting cells from oxidative damage, genotoxicity and can potentially increase their lifespan.

title: Diminution of Oxidative Damage to @entity0 Erythrocytes and Lymphocytes by @entity2 : Possible Role of XXXX in Blood.

answer: @entity2


abstract: UNASSIGNED: @entity2 ( @entity9 ) is naturally produced in the body and stored in muscles where it is involved in energy generation. It is widely used, especially by athletes, as a staple supplement for improving physical performance. Recent reports have shown that @entity9 displays antioxidant activity which could explain its beneficial cellular effects. We have evaluated the ability of @entity9 to protect @entity0 erythrocytes and lymphocytes against oxidative damage. Erythrocytes were challenged with model oxidants, @entity10 (AAPH) and @entity1 ( @entity7 ) in the presence and absence of @entity9 . Incubation of erythrocytes with oxidant alone increased @entity5 , @entity6 levels, lipid peroxidation and protein @entity8 content. This was accompanied by decrease in @entity4 levels. Antioxidant enzymes and antioxidant power of the cell were compromised while the activity of membrane bound enzyme was lowered. This suggests induction of oxidative stress in erythrocytes by AAPH and @entity7 . However, @entity9 protected the erythrocytes by ameliorating the AAPH and @entity7 induced changes in these parameters. This protective effect was confirmed by electron microscopic analysis which showed that oxidant-induced cell damage was attenuated by @entity9 . No cellular alterations were induced by @entity9 alone even at 20 mM, the highest concentration used. @entity3 , a by-product of @entity9 metabolism, was also shown to exert protective effects, although it was slightly less effective than @entity9 . @entity0 lymphocytes were similarly treated with @entity7 in absence and presence of different concentrations of @entity9 . Lymphocytes incubated with oxidant alone had alterations in various biochemical and antioxidant parameters including decrease in cell viability and induction of DNA damage. The presence of @entity9 attenuated all these @entity7 -induced changes in lymphocytes. Thus, @entity9 can function as a blood antioxidant, protecting cells from oxidative damage, genotoxicity and can potentially increase their lifespan.

title: Diminution of Oxidative Damage to XXXX Erythrocytes and Lymphocytes by @entity2 : Possible Role of @entity2 in Blood.

answer: @entity0


abstract: BACKGROUND: This study aims to assess the effects and outcomes of continuous positive airway pressure (CPAP) therapy for @entity1 ( @entity1 ) in @entity0 who have undergone endoscopic dacryocystorhinostomy (DCR). DESIGN: Retrospective series in a university setting. @entity0 : A total of 205 consecutive @entity0 were included in this study. METHODS: A 10-year retrospective review was performed of 205 consecutive @entity0 who had undergone powered endoscopic DCR for nasolacrimal duct obstruction. @entity0 notes were reviewed for demographic, clinical and surgical information. In addition, all @entity0 were contacted and asked to complete a standardized telephone survey relating to @entity1 , CPAP use and associated symptoms. MAIN OUTCOME MEASURE: Effects of CPAP following DCR. RESULTS: Ten of the 205 @entity0 undergoing DCR were identified to use CPAP for @entity1 . Eight @entity0 were initiated on a nasal device, while two used a full-face mask. The mean CPAP pressures were 8 cm H20 (range: 6-10 cm H20). Eighty percent (8/10) of @entity0 complained of symptoms from the use of their CPAP following DCR. The most commonly described symptom was that of air regurgitation in 70% of @entity0 followed by ophthalmic symptoms in 60% (6/10). 50% (5/10) of @entity0 discontinued their CPAP as a consequence of their symptoms with 20% (2/10) discontinuing because of intolerable ophthalmic symptoms. CONCLUSION: Symptoms from CPAP use post-endoscopic DCR are a common occurrence and may contribute to poor compliance with CPAP therapy. Detailed preoperative counseling with regards to CPAP use and its effects should be mandatory in known or at risk @entity1 @entity0 undergoing DCR.

title: Endoscopic XXXX : the effects and outcomes of continuous positive airway pressure therapy.

answer: @entity1


abstract: STUDY DESIGN: The Bracing in @entity1 Trial (BrAIST) included skeletally immature high risk @entity0 with @entity1 ( @entity1 ) with moderate curve sizes (20- 40). BrAIST was a multicenter, controlled trial using both randomized and preference treatment arms into either an observation group or a brace treatment group. OBJECTIVE: The aim was to analyze and compare body image and quality-of-life (QOL) in female @entity1 @entity0 who were observed or treated with a brace. SUMMARY OF BACKGROUND DATA: Brace treatment is an effective means for controlling progressive @entity2 and preventing the need for surgery, but there is no consensus regarding the effect of brace treatment on body image or on QOL in adolescents with @entity1 . METHODS: Data from female BrAIST @entity0 in the randomized (n=132) or preference (n=187) arms and were observed (n=120) or brace treated (n=199) were analyzed. @entity0 completed the Spinal Appearance Questionnaire (SAQ) and the PedsQOL4.0 Generic Scales at baseline and six month follow-up visits up to two years. Items on the SAQ measured three body image constructs (self, ideal, overall). The PedsQOL measured health, activities, feelings, social factors, and school. RESULTS: In general, there were no significant differences within or between study arms or treatments regarding body image or QOL through two years of follow-up. Poorer body image was significantly correlated with poorer QOL during the first two years of follow-up regardless of study arm or treatment. @entity0 that crossed-over to a different treatment and @entity0 with largest Cobb angles >=  40 degrees had significantly poorer body image, in particular self-body image, compared to those that did not. CONCLUSION: This study does not support findings from previous research indicating that wearing a brace has a negative impact on or is negatively impacted by body image or QOL. LEVEL OF EVIDENCE: 4.

title: Body Image and Quality-of-Life in Untreated Versus Brace-Treated Females with XXXX .

answer: @entity1


abstract: AIM: Several HLA alleles have been associated with @entity1 ( @entity1 )-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not been investigated in @entity9 ( @entity9 ). Thus, the purpose of this preliminary study was to determine the association of HLA class I alleles with AED-induced cADRs in @entity9 @entity0 . MATERIALS _ METHODS: This case-control association study included 21 @entity9 @entity0 with @entity7 ( @entity11 )-, @entity4 ( @entity5 )-, or @entity6 (LTG)-induced @entity3 ( @entity3 ) or @entity8 ( @entity8 ); 31 @entity9 @entity0 tolerant to the same @entity1 ; and 225 unrelated, healthy @entity9 volunteers. HLA class I genotyping was performed. Differences in HLA allele frequencies between AED-induced cADR @entity0 and AED-tolerant @entity0 were assessed. Frequencies of alleles possibly associated with AED-induced cADRs in @entity9 @entity0 were compared with those in @entity9 population. RESULTS: The frequency of @entity10 *08:01 allele in @entity11 -induced @entity3 was higher than that in the @entity11 -tolerant group (pc = 0.0179) or in the @entity9 population (pc < 0.0001). For the first time, @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype was associated with LTG-induced @entity3 (pc = 0.0048 for LTG-tolerant groups and pc < 0.0001 for @entity9 population). CONCLUSION: Our data suggest the @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype may be a biomarker for LTG-induced @entity3 and the @entity10 *08:01 allele for @entity11 -induced @entity3 . We also identified @entity2 *01:01:01 and -A*31:01:02 as candidates alleles associated with @entity5 -induced @entity3 in @entity9 @entity0 . However, further investigations are necessary to confirm these findings. Original submitted 28 March 2014; Revision submitted 15 September 2014.

title: XXXX *02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with @entity6 -induced @entity3 in Mexican Mestizo @entity0 .

answer: @entity2


abstract: AIM: Several HLA alleles have been associated with @entity1 ( @entity1 )-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not been investigated in @entity9 ( @entity9 ). Thus, the purpose of this preliminary study was to determine the association of HLA class I alleles with AED-induced cADRs in @entity9 @entity0 . MATERIALS _ METHODS: This case-control association study included 21 @entity9 @entity0 with @entity7 ( @entity11 )-, @entity4 ( @entity5 )-, or @entity6 (LTG)-induced @entity3 ( @entity3 ) or @entity8 ( @entity8 ); 31 @entity9 @entity0 tolerant to the same @entity1 ; and 225 unrelated, healthy @entity9 volunteers. HLA class I genotyping was performed. Differences in HLA allele frequencies between AED-induced cADR @entity0 and AED-tolerant @entity0 were assessed. Frequencies of alleles possibly associated with AED-induced cADRs in @entity9 @entity0 were compared with those in @entity9 population. RESULTS: The frequency of @entity10 *08:01 allele in @entity11 -induced @entity3 was higher than that in the @entity11 -tolerant group (pc = 0.0179) or in the @entity9 population (pc < 0.0001). For the first time, @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype was associated with LTG-induced @entity3 (pc = 0.0048 for LTG-tolerant groups and pc < 0.0001 for @entity9 population). CONCLUSION: Our data suggest the @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype may be a biomarker for LTG-induced @entity3 and the @entity10 *08:01 allele for @entity11 -induced @entity3 . We also identified @entity2 *01:01:01 and -A*31:01:02 as candidates alleles associated with @entity5 -induced @entity3 in @entity9 @entity0 . However, further investigations are necessary to confirm these findings. Original submitted 28 March 2014; Revision submitted 15 September 2014.

title: @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with XXXX -induced @entity3 in Mexican Mestizo @entity0 .

answer: @entity6


abstract: AIM: Several HLA alleles have been associated with @entity1 ( @entity1 )-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not been investigated in @entity9 ( @entity9 ). Thus, the purpose of this preliminary study was to determine the association of HLA class I alleles with AED-induced cADRs in @entity9 @entity0 . MATERIALS _ METHODS: This case-control association study included 21 @entity9 @entity0 with @entity7 ( @entity11 )-, @entity4 ( @entity5 )-, or @entity6 (LTG)-induced @entity3 ( @entity3 ) or @entity8 ( @entity8 ); 31 @entity9 @entity0 tolerant to the same @entity1 ; and 225 unrelated, healthy @entity9 volunteers. HLA class I genotyping was performed. Differences in HLA allele frequencies between AED-induced cADR @entity0 and AED-tolerant @entity0 were assessed. Frequencies of alleles possibly associated with AED-induced cADRs in @entity9 @entity0 were compared with those in @entity9 population. RESULTS: The frequency of @entity10 *08:01 allele in @entity11 -induced @entity3 was higher than that in the @entity11 -tolerant group (pc = 0.0179) or in the @entity9 population (pc < 0.0001). For the first time, @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype was associated with LTG-induced @entity3 (pc = 0.0048 for LTG-tolerant groups and pc < 0.0001 for @entity9 population). CONCLUSION: Our data suggest the @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype may be a biomarker for LTG-induced @entity3 and the @entity10 *08:01 allele for @entity11 -induced @entity3 . We also identified @entity2 *01:01:01 and -A*31:01:02 as candidates alleles associated with @entity5 -induced @entity3 in @entity9 @entity0 . However, further investigations are necessary to confirm these findings. Original submitted 28 March 2014; Revision submitted 15 September 2014.

title: @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with @entity6 -induced XXXX in Mexican Mestizo @entity0 .

answer: @entity3


abstract: AIM: Several HLA alleles have been associated with @entity1 ( @entity1 )-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not been investigated in @entity9 ( @entity9 ). Thus, the purpose of this preliminary study was to determine the association of HLA class I alleles with AED-induced cADRs in @entity9 @entity0 . MATERIALS _ METHODS: This case-control association study included 21 @entity9 @entity0 with @entity7 ( @entity11 )-, @entity4 ( @entity5 )-, or @entity6 (LTG)-induced @entity3 ( @entity3 ) or @entity8 ( @entity8 ); 31 @entity9 @entity0 tolerant to the same @entity1 ; and 225 unrelated, healthy @entity9 volunteers. HLA class I genotyping was performed. Differences in HLA allele frequencies between AED-induced cADR @entity0 and AED-tolerant @entity0 were assessed. Frequencies of alleles possibly associated with AED-induced cADRs in @entity9 @entity0 were compared with those in @entity9 population. RESULTS: The frequency of @entity10 *08:01 allele in @entity11 -induced @entity3 was higher than that in the @entity11 -tolerant group (pc = 0.0179) or in the @entity9 population (pc < 0.0001). For the first time, @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype was associated with LTG-induced @entity3 (pc = 0.0048 for LTG-tolerant groups and pc < 0.0001 for @entity9 population). CONCLUSION: Our data suggest the @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype may be a biomarker for LTG-induced @entity3 and the @entity10 *08:01 allele for @entity11 -induced @entity3 . We also identified @entity2 *01:01:01 and -A*31:01:02 as candidates alleles associated with @entity5 -induced @entity3 in @entity9 @entity0 . However, further investigations are necessary to confirm these findings. Original submitted 28 March 2014; Revision submitted 15 September 2014.

title: @entity2 *02:01:01/-B*35:01:01/-C*04:01:01 haplotype associated with @entity6 -induced @entity3 in Mexican Mestizo XXXX .

answer: @entity0


abstract: STUDY DESIGN.: Retrospective administrative database analysis. OBJECTIVE.: To investigate the incidence and characteristics of pediatric cervical @entity1 utilizing the Kids' Inpatient Database (KID). SUMMARY OF BACKGROUND DATA.: Pediatric cervical @entity1 (PCSI) is debilitating, but comprehensive analyses have been difficult due to its rarity. There have been a few database studies on PCSI; however, the studies employed databases that suffer from selection bias. METHODS.: The triennial KID was queried from years 2000 to 2012 using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Pediatric admissions were divided into five age groups reflecting different developmental stages. PCSI was analyzed in terms of trend, demographics, injury characteristics, hospital characteristics, comorbidities, and outcomes variables. Multivariate logistic regression analyses were used to identify independent risk factors for PCSI among @entity1 admissions and to identify independent risk factors for mortality among PCSI admissions. RESULTS.: Over the past decade, the overall prevalence of traumatic PCSI was 2.07%, and the mortality rate was 4.87%. Most frequent cause of PCSI was transportation accidents, accounting for 57.51%. Upper c- @entity1 (C1-C4), cervical @entity2 with @entity4 , @entity4 without radiographic abnormality (SCIWORA), and dislocation showed a decreasing trend with age. Some comorbidities, including, but not limited to, fluid and electrolyte disorders, and @entity3 were common across all age groups while substance abuse showed a bimodal distribution. Independent risk factors for PCSI after @entity1 were older cohorts, non-Northeast region, and transportation accidents. For mortality after PCSI, independent risk factors were younger cohorts, transportation accidents, upper c- @entity1 , dislocation, and @entity4 . Median length of stay and cost were 3.84 days and  14,742. CONCLUSION.: Pediatric @entity0 are highly heterogeneous, constantly undergoing behavioral, environmental, and anatomical changes. PCSI after @entity1 is more common among older cohorts; however, mortality after sustaining PCSI is higher among younger @entity0 . LEVEL OF EVIDENCE: 4.

title: Pediatric Cervical Spine and XXXX : A National Database Study.

answer: @entity4


abstract: UNASSIGNED: @entity0 recovering from anesthesia are at risk of life threatening @entity1 ( @entity1 ). @entity1 events are rare, and so the study of @entity1 requires the analysis of long cardiorespiratory records. Manual scoring is the preferred method of analysis for these data, but it is limited by low intra- and inter-scorer repeatability. Furthermore, recommended scoring rules do not provide a comprehensive description of the respiratory patterns. This work describes a set of manual scoring tools that address these limitations. These tools include: (i) a set of definitions and scoring rules for 6 mutually exclusive, unique patterns that fully characterize @entity0 respiratory inductive plethysmography (RIP) signals; (ii) RIPScore, a graphical, manual scoring software to apply these rules to @entity0 data; (iii) a library of data segments representing each of the 6 patterns; (iv) a fully automated, interactive formal training protocol to standardize the analysis and establish intra- and inter-scorer repeatability; and (v) a quality control method to monitor scorer ongoing performance over time. To evaluate these tools, three scorers from varied backgrounds were recruited and trained to reach a performance level similar to that of an expert. These scorers used RIPScore to analyze data from @entity0 at risk of @entity1 in two separate, independent instances. Scorers performed with high accuracy and consistency, analyzed data efficiently, had very good intra- and inter-scorer repeatability, and exhibited only minor confusion between patterns. These results indicate that our tools represent an excellent method for the analysis of respiratory patterns in long data records. Although the tools were developed for the study of @entity1 , their use extends to any study of respiratory patterns using RIP (e.g., sleep @entity2 , extubation readiness). Moreover, by establishing and monitoring scorer repeatability, our tools enable the analysis of large data sets by multiple scorers, which is essential for longitudinal and multicenter studies.

title: Scoring Tools for the Analysis of XXXX Respiratory Inductive Plethysmography Signals.

answer: @entity0


abstract: UNASSIGNED: A newly developed recombinant factor IX (BAX326(1) ) was investigated for prophylactic use in paediatric @entity0 aged <12  years with severe ( @entity4 level <1%) or moderately severe ( @entity4 level 1-2%) @entity5 . The aim of this prospective clinical trial was to assess the safety, haemostatic efficacy and pharmacokinetic profile of BAX326 in previously treated paediatric @entity0 . BAX326 was administered as prophylaxis twice a week for a period of 6  months, and on demand for treatment of @entity1 . Safety was assessed by the occurrence of related AEs, @entity2 events and immunologic assessments. Efficacy was evaluated by annualized bleeding rate (ABR), and by treatment response rating (excellent, good, fair, none). PK was assessed over 72  h. None of the 23 treated paediatric subjects had treatment-related SAEs or AEs. There were no @entity2 events, inhibitory or specific binding antibodies against @entity4 , @entity6 or CHO protein. @entity1 (19 @entity3 ) occurred (mean ABR 2.7      3.14, median 2.0), of which 23 were injury-related. Twenty subjects (87%) did not experience any @entity1 of spontaneous aetiology. Haemostatic efficacy of BAX326 was excellent or good for >96% of @entity1 (100% of minor, 88.9% of moderate and 100% of major @entity1 ); the majority (88.5%) resolved after 1-2 infusions. Longer T1/2 and lower IR were observed in younger @entity0 (<6  years) compared to those aged 6 to 12  years. BAX326 administered as prophylactic treatment as well as for controlling @entity1 is efficacious and safe in paediatric @entity0 aged <12  years with @entity5 .

title: Recombinant factor IX (BAX326) in previously treated paediatric @entity0 with XXXX : a prospective clinical trial.

answer: @entity5


abstract: UNASSIGNED: A newly developed recombinant factor IX (BAX326(1) ) was investigated for prophylactic use in paediatric @entity0 aged <12  years with severe ( @entity4 level <1%) or moderately severe ( @entity4 level 1-2%) @entity5 . The aim of this prospective clinical trial was to assess the safety, haemostatic efficacy and pharmacokinetic profile of BAX326 in previously treated paediatric @entity0 . BAX326 was administered as prophylaxis twice a week for a period of 6  months, and on demand for treatment of @entity1 . Safety was assessed by the occurrence of related AEs, @entity2 events and immunologic assessments. Efficacy was evaluated by annualized bleeding rate (ABR), and by treatment response rating (excellent, good, fair, none). PK was assessed over 72  h. None of the 23 treated paediatric subjects had treatment-related SAEs or AEs. There were no @entity2 events, inhibitory or specific binding antibodies against @entity4 , @entity6 or CHO protein. @entity1 (19 @entity3 ) occurred (mean ABR 2.7      3.14, median 2.0), of which 23 were injury-related. Twenty subjects (87%) did not experience any @entity1 of spontaneous aetiology. Haemostatic efficacy of BAX326 was excellent or good for >96% of @entity1 (100% of minor, 88.9% of moderate and 100% of major @entity1 ); the majority (88.5%) resolved after 1-2 infusions. Longer T1/2 and lower IR were observed in younger @entity0 (<6  years) compared to those aged 6 to 12  years. BAX326 administered as prophylactic treatment as well as for controlling @entity1 is efficacious and safe in paediatric @entity0 aged <12  years with @entity5 .

title: Recombinant factor IX (BAX326) in previously treated paediatric XXXX with @entity5 : a prospective clinical trial.

answer: @entity0


abstract: UNASSIGNED: In land systems, equitably managing trade-offs between planetary boundaries and @entity0 development needs represents a grand challenge in sustainability oriented initiatives. Informing such initiatives requires knowledge about the nexus between land use, poverty, and environment. This paper presents results from @entity1 PDR, where we combined nationwide spatial data on land use types and the environmental state of landscapes with village-level poverty indicators. Our analysis reveals two general but contrasting trends. First, landscapes with paddy or permanent @entity2 allow a greater number of @entity0 to live in less poverty but come at the price of a decrease in natural vegetation cover. Second, @entity0 practising extensive @entity2 and living in intact environments are often better off than @entity0 in degraded paddy or permanent @entity2 . As poverty rates within different landscape types vary more than between landscape types, we cannot stipulate a land use-poverty-environment nexus. However, the distinct spatial patterns or configurations of these rates point to other important factors at play. Drawing on ethnicity as a proximate factor for endogenous development potentials and accessibility as a proximate factor for external influences, we further explore these linkages. Ethnicity is strongly related to poverty in all land use types almost independently of accessibility, implying that social distance outweighs geographic or physical distance. In turn, accessibility, almost a precondition for poverty alleviation, is mainly beneficial to ethnic majority groups and @entity0 living in paddy or permanent @entity2 . These groups are able to translate improved accessibility into poverty alleviation. Our results show that the concurrence of external influences with local-highly contextual-development potentials is key to shaping outcomes of the land use-poverty-environment nexus. By addressing such leverage points, these findings help guide more effective development interventions. At the same time, they point to the need in land change science to better integrate the understanding of place-based land indicators with process-based drivers of land use change.

title: Towards a Spatial Understanding of Trade-Offs in Sustainable Development: A Meso-Scale Analysis of the Nexus between Land Use, Poverty, and Environment in the XXXX PDR.

answer: @entity1


abstract: OBJECTIVES: Severe @entity4 after liver transplant is common. In this study, our aim was to develop an algorithm to guide biliary intervention in these @entity0 . MATERIALS AND METHODS: A retrospective review was performed on @entity0 who had undergone a hepatobiliary scan, with or without subsequent endoscopic retrograde cholangiogram, during the immediate postoperative period. These findings were evaluated along with laboratory values to determine the benefit for this evaluative process. @entity4 was defined as > than a 50% reduction in serum @entity3 within 48 hours of endoscopic retrograde cholangiogram intervention. RESULTS: Twelve @entity0 had endoscopic retrograde cholangiogram with 6 stents in 25 @entity0 with normal a hepatobiliary scan, and 2 @entity0 met criteria for @entity4 . Twenty-two @entity0 had endoscopic retrograde cholangiogram with 14 stents in 32 @entity0 with delayed uptake, suggesting hepatocellular dysfunction on a hepatobiliary scan, and 4 @entity0 met criteria for @entity4 . In the 57 @entity0 with severe @entity5 , 6 @entity0 (11%) had @entity4 as a cause. Among the 34 endoscopic retrograde cholangiograms performed, 17% had @entity1 . On multivariate analysis, @entity0 having both serum @entity2 transaminase concentrations < 1500 IU/L and serum total @entity3 levels > 257  mol/L had an odds ratio of 25.1 for predicting @entity1 (95% CI: 6-37; P = .002). CONCLUSIONS: A hepatobiliary scan with a combination peak serum @entity2 transaminase and peak serum total @entity3 levels offer a valuable tool to identify @entity0 with hepatocellular dysfunction and can avoid endoscopic retrograde cholangiogram in the immediate posttransplant period.

title: Clinical algorithm to guide the need for endoscopic retrograde cholangiopancreatography to evaluate early postliver transplant XXXX .

answer: @entity4


abstract: BACKGROUND: To determine @entity3 during @entity1 ( @entity1 ) administrated through a peripheral venous line, PICC-line or PORT-A-CATH (PAC). METHODS: Catheter related @entity3 in @entity0 with @entity5 during @entity1 were identified through a retrospective review of @entity0 files supplemented by an interview. RESULTS: In 64 treatment episodes with a peripheral venous line, 51 (79.7  %) used bolus injection and 13 (20.3  %) used infusion pump. 27 out of 51 (53.0  %) bolus injection episodes experienced @entity3 , which required removal. None were observed for infusion pump treatments. The infectious @entity3 requiring removal of peripheral venous line were 9 out of 23 (39.1  %) for the PICC line and 11 out of 26 (42.3  %) for the PAC. No anaphylaxis was observed during the @entity1 treatments. CONCLUSIONS: Our data indicate that using an infusion pump to administer the antibiotic treatment minimized @entity4 . The frequency of @entity3 leading to removal of the catheter is about the same for PICC-lines and PACs, but the average life-time of the latter is much longer. @entity2 are not a major problem.

title: Outpatient parenteral antimicrobial therapy ( @entity1 ) in @entity0 with XXXX .

answer: @entity5


abstract: BACKGROUND: To determine @entity3 during @entity1 ( @entity1 ) administrated through a peripheral venous line, PICC-line or PORT-A-CATH (PAC). METHODS: Catheter related @entity3 in @entity0 with @entity5 during @entity1 were identified through a retrospective review of @entity0 files supplemented by an interview. RESULTS: In 64 treatment episodes with a peripheral venous line, 51 (79.7  %) used bolus injection and 13 (20.3  %) used infusion pump. 27 out of 51 (53.0  %) bolus injection episodes experienced @entity3 , which required removal. None were observed for infusion pump treatments. The infectious @entity3 requiring removal of peripheral venous line were 9 out of 23 (39.1  %) for the PICC line and 11 out of 26 (42.3  %) for the PAC. No anaphylaxis was observed during the @entity1 treatments. CONCLUSIONS: Our data indicate that using an infusion pump to administer the antibiotic treatment minimized @entity4 . The frequency of @entity3 leading to removal of the catheter is about the same for PICC-lines and PACs, but the average life-time of the latter is much longer. @entity2 are not a major problem.

title: Outpatient parenteral antimicrobial therapy ( XXXX ) in @entity0 with @entity5 .

answer: @entity1


abstract: BACKGROUND: To determine @entity3 during @entity1 ( @entity1 ) administrated through a peripheral venous line, PICC-line or PORT-A-CATH (PAC). METHODS: Catheter related @entity3 in @entity0 with @entity5 during @entity1 were identified through a retrospective review of @entity0 files supplemented by an interview. RESULTS: In 64 treatment episodes with a peripheral venous line, 51 (79.7  %) used bolus injection and 13 (20.3  %) used infusion pump. 27 out of 51 (53.0  %) bolus injection episodes experienced @entity3 , which required removal. None were observed for infusion pump treatments. The infectious @entity3 requiring removal of peripheral venous line were 9 out of 23 (39.1  %) for the PICC line and 11 out of 26 (42.3  %) for the PAC. No anaphylaxis was observed during the @entity1 treatments. CONCLUSIONS: Our data indicate that using an infusion pump to administer the antibiotic treatment minimized @entity4 . The frequency of @entity3 leading to removal of the catheter is about the same for PICC-lines and PACs, but the average life-time of the latter is much longer. @entity2 are not a major problem.

title: Outpatient parenteral antimicrobial therapy ( @entity1 ) in XXXX with @entity5 .

answer: @entity0


abstract: BACKGROUND: The Lab-score, based on the combined determination of @entity3 , @entity2 and urinary dipstick results, has been shown accurate in detecting serious @entity4 (SBI) in @entity0 with @entity1 ( @entity1 ) on retrospective cohorts. We aimed to prospectively assess the utility of the Lab-score in safely decreasing antibiotic prescriptions in @entity0 with @entity1 and to determine its diagnostic characteristics compared to common SBI biomarkers. METHODS: Randomized controlled trial in @entity0 7 days to 36 months old with @entity1 , allocated either to the Lab-score group (Lab-score reported, blinded WBC count) or to the control group (WBC, bands and @entity2 determined, blinded @entity3 and Lab-score), followed up until recovery. Demographic data, antibiotic prescription rate, admission rate and diagnostic properties of the Lab-score were analyzed. RESULTS: 271 @entity0 were analyzed. No statistically significant difference concerning antibiotic prescription rate was observed: 41.2% (54 of 131) in the Lab-score group and 42.1% (59 of 140) in the control group (p=1.000). If recommendations based on the Lab-score had been strictly applied, a hypothetical 30.6% treatment rate would have been encountered, compared to the overall 41.7% observed rate (p=0.0095). A Lab-score >= 3 showed the following characteristics: sensitivity 85.1% (95% CI: 76.5-93.6%), specificity 87.3% (95% CI: 82.7-91.8%), positive predictive value 68.7% (95% CI: 58.7-78.7%), negative predictive value 94.1% (95% CI: 91.5-97.9%), positive and negative likelihood ratios: 6.68 and 0.17 respectively. Area under the receiver operating characteristic curve was best for the Lab-score (0.911, 95% CI: 0.871-0.950). DISCUSSION: No difference regarding antibiotic treatment rate was observed when using the Lab-score, due to lack of adherence to the related recommendations. However, if strictly followed, a significant 26.5% reduction of antibiotic prescriptions would have been encountered. Medical education needs to be reinforced in order to observe rather than treat low-risk well-appearing @entity0 with @entity1 . TRIAL REGISTRATION: ClinicalTrials.gov NCT02179398.

title: Impact of the Lab-Score on Antibiotic Prescription Rate in XXXX with Fever without Source: A Randomized Controlled Trial.

answer: @entity0


abstract: UNASSIGNED: In deep-sea hydrothermal environments, most invertebrates associate with dense populations of symbiotic microorganisms in order to obtain nutrition. The molecular interactions between deep-sea animals and environmental microbes, including their symbionts, have not yet been elucidated in detail. Hemagglutinins/lectins, which are @entity2 -binding proteins, have recently been reported to play important roles in a wide array of biological processes, including the recognition and control of non-self materials. We herein assessed hemagglutination activity in the serum of a deep-sea vent endemic crab, @entity4 , which harbors chemosynthetic epibionts on its plumose setae. @entity1 and @entity0 erythrocytes were agglutinated using this serum (opt. pH 7.5 and opt. temperature 15  C). Agglutinating activity was inhibited by eight kinds of @entity3 and several divalent cations, did not require any divalent metal ions, and remained detectable even after heating the serum at 100  C for 30 min. By using fluorescently labeled serum, we demonstrated that deep-sea crab serum components bound to the epibionts even in the presence of @entity3 . This study represents the first immunological assessment of a deep-sea vent endemic crab and demonstrated the possibility of a non-lectin-mediated symbiont-host interaction.

title: Effects of Hemagglutination Activity in the Serum of a Deep-Sea Vent Endemic Crab, XXXX , on Non-Symbiotic and Symbiotic Bacteria.

answer: @entity4


abstract: PURPOSE: This study assessed the performance of a novel flow cytometry (FCM) cervical @entity1 screening system compared with @entity4 ) Hybrid Capture 2 (HC2). METHODS: Chinese @entity0 aged 20years or older were enrolled in this study at Fudan University Shanghai @entity1 Center. All @entity0 underwent cytology/pathology testing (gold standard), HPV HC2 testing and FCM testing involving analysis of cell proliferation index (CPIx). RESULTS: Among 437 @entity0 enrolled in this study, 185 @entity0 (42.3%) were diagnosed as "gold standard positive" by pathology with diseases including @entity5 ( @entity5 ) grade 2 (n=11), CIN3 (n=41), @entity3 ( @entity3 ; n=115), @entity2 in situ (n=2) and @entity2 (n=16). The remaining 252 cases were deemed "gold standard negative". The sensitivity was 87.6% (95% CI, 82.8-92.3) for FCM testing and 89.7% (95% CI, 85.4-94.1; p=0.5121) for HPV HC2 testing. The specificity of FCM testing was 90.5% (95% CI, 86.2-94.7), which was superior to the specificity of HPV HC2 testing (84.5%, 95% CI, 79.3-89.7; p=0.04). In the 20-29years old group, the sensitivity and the specificity of FCM testing were 90.0% (95% CI, 71.4-100.0) and 92.9% (95% CI, 76.9-100.0), respectively. The FCM testing CPIx statistically increased with the transition from normal cervical specimens to @entity3 specimens. CONCLUSIONS: Our results showed that the FCM screening system had high sensitivity and specificity for @entity0 of various ages. The FCM CPIx was able to evaluate the severity of disease quantitatively.

title: A novel highly sensitive and specific flow cytometry system for cervical XXXX screening.

answer: @entity1


abstract: In fungi, unisexual reproduction, where sexual development is initiated without the presence of two compatible mating type alleles, has been observed in several species that can also undergo traditional bisexual reproduction, including the important @entity0 fungal pathogens @entity3 and @entity5 . While unisexual reproduction has been well characterized qualitatively, detailed quantifications are still lacking for aspects of this process, such as the frequency of recombination during unisexual reproduction, and how this compares with bisexual reproduction. Here, we analyzed meiotic recombination during a-a unisexual and a-a bisexual reproduction of @entity3 . We found that meiotic recombination operates in a similar fashion during both modes of @entity2 . Specifically, we observed that in a-a unisexual reproduction, the numbers of crossovers along the chromosomes during meiosis, recombination frequencies at specific chromosomal regions, as well as meiotic recombination hot and cold spots, are all similar to those observed during a-a bisexual reproduction. The similarity in meiosis is also reflected by the fact that phenotypic segregation among progeny collected from the two modes of @entity2 is also similar, with transgressive segregation being observed in both. Additionally, we found diploid meiotic progeny were also produced at similar frequencies in the two modes of @entity2 , and transient @entity1 and duplication likely occurs frequently and results in @entity4 and loss of heterozygosity that can span entire chromosomes. Furthermore, in both a-a unisexual and a-a bisexual reproduction, we observed biased allele inheritance in regions on chromosome 4, suggesting the presence of fragile chromosomal regions that might be vulnerable to mitotic recombination. Interestingly, we also observed a crossover event that occurred within the MAT locus during a-a unisexual reproduction. Our results provide definitive evidence that a-a unisexual reproduction is a meiotic process similar to a-a bisexual reproduction.

title: Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in XXXX .

answer: @entity3


abstract: UNASSIGNED: Alternaria toxins and @entity3 are mycotoxins produced by fungi growing on different raw materials and agricultural commodities. Maximum levels of these toxins in foods are currently under consideration by the European Commission as a risk management measure. In this study, a new quantitative method is described for the determination of five Alternaria toxins and @entity3 in @entity1 and @entity1 juice samples based on LC- @entity0 / @entity0 detection. Samples were extracted with pure @entity2 , followed by a derivatisation step with @entity4 to improve the determination of @entity5 and to decrease the wide polarity difference between the compounds of interest. Samples were purified on hydrophilic-modified styrene polymer solid-phase extraction cartridges. High-performance liquid chromatographic columns packed with different core-shell materials were tested for the separation of toxins and a C-18 phase was in the final method applied to achieve sufficient separation of all relevant analytes. A key element of this approach was to prove successful transferability of the method to three different triple quadrupole mass spectrometers. A full single laboratory method validation was performed on two LC- @entity0 / @entity0 systems and performance characteristics met the predefined requirements. Moreover, the method was used in an international proficiency test and the satisfactory z-scores obtained (-0.1 to 0.8 in @entity1 juice samples) demonstrated the reliability of the approach described. The method will be validated in an inter-laboratory collaborative study and if the criteria for method precision are met, the method will be proposed as a new Work Item to the European Committee for Standardisation.

title: Simultaneous analysis of Alternaria toxins and XXXX in @entity1 : an optimised method using liquid chromatography-tandem mass spectrometry.

answer: @entity3


abstract: UNASSIGNED: Alternaria toxins and @entity3 are mycotoxins produced by fungi growing on different raw materials and agricultural commodities. Maximum levels of these toxins in foods are currently under consideration by the European Commission as a risk management measure. In this study, a new quantitative method is described for the determination of five Alternaria toxins and @entity3 in @entity1 and @entity1 juice samples based on LC- @entity0 / @entity0 detection. Samples were extracted with pure @entity2 , followed by a derivatisation step with @entity4 to improve the determination of @entity5 and to decrease the wide polarity difference between the compounds of interest. Samples were purified on hydrophilic-modified styrene polymer solid-phase extraction cartridges. High-performance liquid chromatographic columns packed with different core-shell materials were tested for the separation of toxins and a C-18 phase was in the final method applied to achieve sufficient separation of all relevant analytes. A key element of this approach was to prove successful transferability of the method to three different triple quadrupole mass spectrometers. A full single laboratory method validation was performed on two LC- @entity0 / @entity0 systems and performance characteristics met the predefined requirements. Moreover, the method was used in an international proficiency test and the satisfactory z-scores obtained (-0.1 to 0.8 in @entity1 juice samples) demonstrated the reliability of the approach described. The method will be validated in an inter-laboratory collaborative study and if the criteria for method precision are met, the method will be proposed as a new Work Item to the European Committee for Standardisation.

title: Simultaneous analysis of Alternaria toxins and @entity3 in XXXX : an optimised method using liquid chromatography-tandem mass spectrometry.

answer: @entity1


abstract: BACKGROUND: Complex traumatic upper extremity injuries frequently possess compromised local vasculature or extensive defects that are not amenable to local flap reconstruction. Free tissue transfer is required to provide adequate soft tissue coverage. The present study aimed to evaluate risk factors that contribute to @entity2 and @entity4 in complex upper extremity reconstruction. METHODS: Retrospective chart review was performed for all @entity0 undergoing free tissue transfer for upper extremity reconstruction from 1976 to 2001. Data collected included @entity0 demographic characteristics, timing of reconstruction, location of @entity1 characteristics, operative interventions, and @entity2 . Statistical analysis was performed using   (2) and Fisher exact tests. RESULTS: In total, 238 @entity0 underwent 285 free tissue transfers and met inclusion criteria, from which 3 were excluded because of inadequate information (n  =  282). Extremities were repaired within 24  h (75 cases; 27%), in days 2-7 (32 cases; 12%), or after day 7 (172 cases; 62%). Timing of reconstruction did not significantly affect postoperative outcomes. Proximal location of injury was significantly associated with superficial (relative risk [RR], 6.5; P  <  .01) and @entity3 (RR, 5.3; P  <  .01), and @entity5 (RR, 4.0; P  <  .01), although not with flap failure (P  =  .30). Presence of an open @entity1 was significantly associated with developing superficial (RR, 3.1; P  =  .01) and deep (RR, 1.9; P  <  .01) infection, as well as @entity5 (RR, 1.6; P  <  .01). Having a closed @entity1 did not negatively influence postoperative outcomes. CONCLUSIONS: This study supports the safety of early free tissue transfer for reconstruction of traumatized upper extremities. Injuries proximal to the elbow and open @entity1 were associated with a significantly higher infection rate. Gustilo grade IIIC @entity1 , need for interpositional vein grafts, and anastomotic revision at index operation resulted in significantly higher risk of @entity4 , whereas the presence of @entity1 , @entity1 fixation, and injury location were not predictors of flap failure.

title: Free tissue transfer to the traumatized upper extremity: Risk factors for XXXX in 282 cases.

answer: @entity2


abstract: UNASSIGNED: @entity0 with longstanding trigger finger may develop @entity4 at the proximal interphalangeal (PIP) joint that persists even after division of the A1 pulley. The purpose of this study was to explore the hypothesis that @entity5 in advanced trigger finger is caused by severe adhesion between the flexor digitorum superficialis (FDS) and the @entity6 ( @entity6 ) tendons. Ten freshly frozen cadaveric hands were used in the experiments. After preparation of the extrinsic flexor, extrinsic extensor, and @entity2 , we applied weights to the flexor tendons and minimal tension to the extrinsic extensor and @entity2 . We then measured the initial flexion angles of the metacarpophalangeal (MCP) and @entity5 . Next, we measured the flexion angles of the MCP and @entity5 as increasing tension was applied to the extrinsic extensor and @entity2 , respectively. We repeated these experiments after constructing flexor @entity3 model. The @entity5 were greater in the adhesion model, as were the average tensions required for full extension of these joints. Our results suggest that adhesion between two flexor tendons contributes to progression of @entity1 in the PIP joint.    2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:XX-XX, 2014.

title: Biomechanical analyses of the @entity0 flexor XXXX models in the hand: A cadaveric study.

answer: @entity3


abstract: UNASSIGNED: @entity0 with longstanding trigger finger may develop @entity4 at the proximal interphalangeal (PIP) joint that persists even after division of the A1 pulley. The purpose of this study was to explore the hypothesis that @entity5 in advanced trigger finger is caused by severe adhesion between the flexor digitorum superficialis (FDS) and the @entity6 ( @entity6 ) tendons. Ten freshly frozen cadaveric hands were used in the experiments. After preparation of the extrinsic flexor, extrinsic extensor, and @entity2 , we applied weights to the flexor tendons and minimal tension to the extrinsic extensor and @entity2 . We then measured the initial flexion angles of the metacarpophalangeal (MCP) and @entity5 . Next, we measured the flexion angles of the MCP and @entity5 as increasing tension was applied to the extrinsic extensor and @entity2 , respectively. We repeated these experiments after constructing flexor @entity3 model. The @entity5 were greater in the adhesion model, as were the average tensions required for full extension of these joints. Our results suggest that adhesion between two flexor tendons contributes to progression of @entity1 in the PIP joint.    2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:XX-XX, 2014.

title: Biomechanical analyses of the XXXX flexor @entity3 models in the hand: A cadaveric study.

answer: @entity0


abstract: OBJECTIVE: This study investigates patterns of physical activity in older adults with @entity2 ( @entity1 ) compared to older adults without knee @entity1 across six European countries. We expect country specific differences in the physical activity levels between @entity0 with knee @entity1 compared to @entity0 without knee @entity1 . A varying degree of physical activity levels across countries would express a facilitating or impeding influence of the social, environmental and other contextual factors on a physically active lifestyle. METHODS: Baseline cross-sectional data from the European Project on @entity1 (EPOSA) were analysed. In total 2,551 @entity0 from six European countries (Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom) were included. RESULTS: @entity0 with knee @entity1 were less likely to follow physical activity recommendations and had poorer overall physical activity profiles than those without knee @entity1 (M=62.9 versus M=81.5 minutes/day, p = 0.015). The magnitude of this difference varied across countries. Detailed analysis showed that low physical activity levels in @entity0 with knee @entity1 could be attributed to less everyday walking time [OR 1.31, 95% CI 1.07-1.62]. CONCLUSION: This study highlighted that having knee @entity1 is associated with a varying degree of physical activity patterns in different countries. This implicates that low levels of physical activity among @entity0 with knee @entity1 cannot be explained exclusively by individual or disease specific factors, but social, environmental and other contextual factors should also be taken into account. This article is protected by copyright. All rights reserved.

title: Physical activity patterns among older adults with and without XXXX in six European Countries.

answer: @entity2


abstract: OBJECTIVE: @entity3 ( @entity3 ) frequently leads to secondary generalized @entity2 (SGTCS). However, little is known about the clinical, electrophysiologic, and radiologic correlates of SGTCS and whether these could influence diagnosis and treatment. METHODS: A cohort of 48 @entity0 with confirmed @entity3 was retrospectively identified and dichotomized into a group with and a group without SGTCS defined by history (>= 1/year) or video-electroencephalography (vEEG). Demographics, @entity2 semiology, vEEG, neuroimaging data, and estimated @entity2 -onset zone were tabulated, and their association with the occurrence of SGTCS was evaluated with use of a chi-square test. Independent predictors of SGTCS were confirmed using a stepwise multivariate analysis. Similarly, these predictors as well as a history of SGTCS were tested as multivariate predictors of the postoperative International League Against @entity1 (ILAE) score in the surgical subgroup (n  =  25). RESULTS: We identified three independent predictors of a history of SGTCS in @entity3 , including loss of responsiveness at @entity2 onset (corrected p  =  0.04), a semiology involving early elementary motor signs (corrected p  =  0.01), and multifocal spikes on EEG (corrected p  =  0.02). A @entity2 -free outcome occurred in 57% of surgical cases and was more likely in the group without SGTCS (100%, p  =  0.001). When considering only SGTCS occurring during video-EEG monitoring, the association with semiology and surgical outcome vanished, but the association with preserved awareness and a multifocal EEG persisted. SIGNIFICANCE: A history of SGTCS is related to a specific ictal semiology and interictal EEG, and may have a role in surgical risk stratification.

title: Recurrent secondary generalization in XXXX : Predictors and a potential link to surgical outcome?

answer: @entity3


abstract: We report a rare case of @entity4 caused by bilateral @entity5 -secreting @entity3 in a 63-year-old @entity0 . Our preoperative diagnosis was based on endocrinological results and imaging findings. Laparoscopic adrenalectomy has become a standard technique for @entity1 ; however, bilateral adrenalectomy results in postoperative @entity7 , necessitating lifelong @entity2 replacement. To preserve adrenal function, the left adrenal gland was completely resected, whereas the right adrenal gland was partially resected laparoscopically. @entity5 supplementation was initiated at a dose of 30 mg/day and was slowly tapered. However, symptoms of @entity7 developed, and adrenal @entity2 secretion did not respond to exogenous @entity8 . Bilateral @entity5 -secreting @entity1 rarely cause @entity4 . The present study comprised few @entity0 , and the utilized surgical procedures (i.e., total/partial adrenalectomy or bilateral total adrenalectomy) were not uniform. Few cases of bilateral adrenal-preserving surgery have been reported. However, our @entity0 developed @entity7 after the oral @entity6 supplementation was tapered. This report demonstrates that partial adrenalectomy does not necessarily preserve normal adrenocortical function. Therefore, careful postoperative observation is necessary for @entity0 undergoing a partial adrenalectomy.

title: A Rare Case of XXXX Due to Bilateral Adrenocortical Adenomas.

answer: @entity4


abstract: Purpose: Severe @entity1 can have a profound impact on personal independence through its effect on mobility. We investigated whether the mobility of @entity0 with vision low enough to be registered as blind could be improved by presenting the visual environment in a distance-based manner for easier detection of obstacles. Methods: We accomplished this by developing a pair of "residual vision glasses" (RVGs) that use a head-mounted depth camera and displays to present information about the distance of obstacles to the wearer as brightness, such that obstacles closer to the wearer are represented more brightly. We assessed the impact of the RVGs on the mobility performance of @entity1 @entity0 during the completion of a set of obstacle courses. @entity0 position was monitored continuously, which enabled us to capture the temporal dynamics of mobility performance. This allowed us to find correlates of obstacle detection and hesitations in walking behavior, in addition to the more commonly used measures of trial completion time and number of collisions. Results: All @entity0 were able to use the smart glasses to navigate the course, and mobility performance improved for those @entity1 @entity0 with the worst prior mobility performance. However, walking speed was slower and hesitations increased with the altered visual representation. Conclusions: A depth-based representation of the visual environment may offer @entity2 @entity0 improvements in independent mobility. It is important for further work to explore whether practice can overcome the reductions in speed and increased hesitation that were observed in our trial.

title: Improving Mobility Performance in XXXX With a Distance-Based Representation of the Visual Scene.

answer: @entity2


abstract: UNASSIGNED: Acquired @entity5 and associated @entity1 can be consequences of immunoglobulin light chain @entity4 . There are limited data on the safety and efficacy of autologous stem cell transplant (ASCT) on @entity5 . We retrospectively reviewed immunoglobulin light chain @entity4 @entity0 with factor X levels below 50%, not on chronic anticoagulation who underwent ASCT at the Mayo Clinic, Rochester, Minnesota, USA, between April 1995 and December 2011. Twenty-seven of 358 @entity0 (7.5%) met study criteria. Median pre-ASCT factor X was 36% (range: 2-49%). The most frequent and severe @entity1 complications occurred in @entity0 with factor X levels below 10%. Peri-procedural prophylaxis included activated recombinant factor VII, fresh frozen plasma and platelet transfusions. Steady-state post-ASCT factor X levels were determined in 12 @entity0 . Post-ASCT factor X levels increased in 100% of @entity0 , with median factor X improvement of +32% (range: +8 to +92%). About 46.2% of @entity0 were no longer factor X deficient after ASCT. The degree of improvement in factor X levels was correlated with an improvement in markers of renal involvement by amyloid. Improvement in factor X correlated with an improvement in the degree of total serum protein (  =0.54; P=0.04) and @entity2 (  =-0.54; P=0.04). Our findings support the decision to offer ASCT to factor @entity3 @entity0 as both appropriate and efficacious.

title: Autologous stem cell transplantation in immunoglobulin light chain XXXX with @entity5 .

answer: @entity4


abstract: UNASSIGNED: Acquired @entity5 and associated @entity1 can be consequences of immunoglobulin light chain @entity4 . There are limited data on the safety and efficacy of autologous stem cell transplant (ASCT) on @entity5 . We retrospectively reviewed immunoglobulin light chain @entity4 @entity0 with factor X levels below 50%, not on chronic anticoagulation who underwent ASCT at the Mayo Clinic, Rochester, Minnesota, USA, between April 1995 and December 2011. Twenty-seven of 358 @entity0 (7.5%) met study criteria. Median pre-ASCT factor X was 36% (range: 2-49%). The most frequent and severe @entity1 complications occurred in @entity0 with factor X levels below 10%. Peri-procedural prophylaxis included activated recombinant factor VII, fresh frozen plasma and platelet transfusions. Steady-state post-ASCT factor X levels were determined in 12 @entity0 . Post-ASCT factor X levels increased in 100% of @entity0 , with median factor X improvement of +32% (range: +8 to +92%). About 46.2% of @entity0 were no longer factor X deficient after ASCT. The degree of improvement in factor X levels was correlated with an improvement in markers of renal involvement by amyloid. Improvement in factor X correlated with an improvement in the degree of total serum protein (  =0.54; P=0.04) and @entity2 (  =-0.54; P=0.04). Our findings support the decision to offer ASCT to factor @entity3 @entity0 as both appropriate and efficacious.

title: Autologous stem cell transplantation in immunoglobulin light chain @entity4 with XXXX .

answer: @entity5


abstract: UNASSIGNED: Prophylactic surgical options for @entity4 ( @entity4 ) are either colectomy and ileorectal @entity2 (IRA) or proctocolectomy and ileal pouch-anal @entity2 (IPAA). The aim of this study was to analyse the short-term and long-term outcomes of these two operative techniques. All @entity0 with @entity4 in Finland have been prospectively recorded in a database since 1963 were retrospectively reviewed in this analysis. Altogether 140 (61  %) colectomies with IRA and 88 (39  %) proctocolectomies with IPAA have been performed. Complications occurred in 28 (21  %) @entity0 after IRA and in 26 (30  %) @entity0 after IPAA. There were 15 (11  %) severe complications for IRA and 5 (6  %) for IPAA. Twenty-one (15  %) @entity0 of the IRA group ended up in conventional ileostomy whereas 3 (3.4  %) @entity0 of the IPAA group had their ileal reservoir converted to an ileostomy (p  =  0.01). Cumulative survival for IRA was lower than for the IPAA (p  =  0.03), but if accounting only for operations made after the IPAA era had commenced, there was no significant difference. IPAA was associated with improved long-term survival without an @entity3 . The risk of death after colectomy and IRA seemed to be predominantly related to the remaining risk of @entity1 . Therefore, we favour proctocolectomy with IPAA as the prophylactic surgical procedure for @entity4 with intermediate or severe @entity4 .

title: Comparison of proctocolectomy and ileal pouch-anal @entity2 to colectomy and ileorectal @entity2 in XXXX .

answer: @entity4


abstract: UNASSIGNED: Prophylactic surgical options for @entity4 ( @entity4 ) are either colectomy and ileorectal @entity2 (IRA) or proctocolectomy and ileal pouch-anal @entity2 (IPAA). The aim of this study was to analyse the short-term and long-term outcomes of these two operative techniques. All @entity0 with @entity4 in Finland have been prospectively recorded in a database since 1963 were retrospectively reviewed in this analysis. Altogether 140 (61  %) colectomies with IRA and 88 (39  %) proctocolectomies with IPAA have been performed. Complications occurred in 28 (21  %) @entity0 after IRA and in 26 (30  %) @entity0 after IPAA. There were 15 (11  %) severe complications for IRA and 5 (6  %) for IPAA. Twenty-one (15  %) @entity0 of the IRA group ended up in conventional ileostomy whereas 3 (3.4  %) @entity0 of the IPAA group had their ileal reservoir converted to an ileostomy (p  =  0.01). Cumulative survival for IRA was lower than for the IPAA (p  =  0.03), but if accounting only for operations made after the IPAA era had commenced, there was no significant difference. IPAA was associated with improved long-term survival without an @entity3 . The risk of death after colectomy and IRA seemed to be predominantly related to the remaining risk of @entity1 . Therefore, we favour proctocolectomy with IPAA as the prophylactic surgical procedure for @entity4 with intermediate or severe @entity4 .

title: Comparison of proctocolectomy and ileal pouch-anal XXXX to colectomy and ileorectal @entity2 in @entity4 .

answer: @entity2


abstract: UNASSIGNED: Prophylactic surgical options for @entity4 ( @entity4 ) are either colectomy and ileorectal @entity2 (IRA) or proctocolectomy and ileal pouch-anal @entity2 (IPAA). The aim of this study was to analyse the short-term and long-term outcomes of these two operative techniques. All @entity0 with @entity4 in Finland have been prospectively recorded in a database since 1963 were retrospectively reviewed in this analysis. Altogether 140 (61  %) colectomies with IRA and 88 (39  %) proctocolectomies with IPAA have been performed. Complications occurred in 28 (21  %) @entity0 after IRA and in 26 (30  %) @entity0 after IPAA. There were 15 (11  %) severe complications for IRA and 5 (6  %) for IPAA. Twenty-one (15  %) @entity0 of the IRA group ended up in conventional ileostomy whereas 3 (3.4  %) @entity0 of the IPAA group had their ileal reservoir converted to an ileostomy (p  =  0.01). Cumulative survival for IRA was lower than for the IPAA (p  =  0.03), but if accounting only for operations made after the IPAA era had commenced, there was no significant difference. IPAA was associated with improved long-term survival without an @entity3 . The risk of death after colectomy and IRA seemed to be predominantly related to the remaining risk of @entity1 . Therefore, we favour proctocolectomy with IPAA as the prophylactic surgical procedure for @entity4 with intermediate or severe @entity4 .

title: Comparison of proctocolectomy and ileal pouch-anal @entity2 to colectomy and ileorectal XXXX in @entity4 .

answer: @entity2


abstract: PURPOSE: In Caucasian @entity0 , research has shown that energy balance and taste preference change throughout the menstrual cycle. However, the contributory role of the menstrual cycle to @entity1 and insulin resistance among Asian @entity0 remains unclear. We investigate the impact of the menstrual cycle on energy balance and taste preference in Singaporean Chinese females. METHODS: Thirty-one healthy young Chinese female subjects with regular menstrual cycles were recruited. Anthropometrics, body composition, energy intake, resting metabolic rate, @entity4 ( @entity4 ) severity and taste preference to @entity2 were assessed during three phases (menses, follicular and luteal), over one (N  =  18) to two (N  =  13) menstrual cycles. RESULTS: For all subjects (N  =  31), we found significant reductions in energy, fat intake (p  <  0.05) and taste preference for @entity2 (p  <  0.05) in the luteal phase compared to early follicular phase as far as Cycle 1 is concerned. No significant differences were observed for @entity3 and protein intake as well as @entity4 score. In those evaluated for two full cycles (N  =  13), we found that taste preference for @entity2 and @entity4 score were significantly higher in the menstrual phase in Cycle 2 (p  <  0.05). No significant differences were observed in energy and macronutrient intake throughout Cycle 2. RMR was similar across the three phases. However, non-significant cyclic variations were noted within and between the cycles. CONCLUSION: Cyclic variations in energy intake and expenditure contributed by sensory and behavioural changes occur during the menstrual cycle. Whether this contributes to cyclic weight gain is speculative and remains to be proven. Further research in non-Caucasians spanning more than one menstrual cycle is needed to establish the impact of the menstrual cycle on taste preference and energy balance.

title: The influence of the menstrual cycle on energy balance and taste preference in Asian Chinese XXXX .

answer: @entity0


abstract: A prospective clinical study was carried out to investigate whether endometrial microvessels in @entity0 with @entity3 (HMB) of endometrial origin (HMB-E) are fragile due to low pericyte coverage. Idiopathic HMB-E is characterized by large endothelial cell gaps related to the microvascular overexpression of @entity1 ( @entity1 )-A and @entity1 receptors  1-3. A total of 10  @entity0 with a normal menstrual cycle and a history of HMB of <5  years, and 17  healthy @entity0 with a normal menstrual cycle were recruited from the Karolinska University Hospital. Blood samples were obtained for hormone analysis and coagulation tests. Endometrial biopsies were collected in the proliferative or in the secretory phase. Pericyte coverage was assessed using immunohistochemical staining for smooth muscle actin-a  (SMAa) and by image analysis (microvascular density) of endometrial biopsies from 10  @entity0 with HMB-E and 17  healthy ovulating @entity0 (control subjects). Previously published data on endothelial cell gap size and the expression of @entity1 receptors were used. Although microvascular density did not differ between the @entity0 with HMB-E and the control subjects, the number of SMAa-positive microvessels in the proliferative phase was significantly (P=0.005) lower in the @entity0 with HMB-E than in the control subjects. Moreover, the number of SMAa-positive microvessels in the control subjects was significantly fewer in the secretory (P=0.04) than in the proliferative phase, whereas this number did not differ among the @entity0 with HMB-E regardless of phase. A significant negative correlation was observed between the number of @entity1 -positive microvessels and microvessels with pericyte coverage (r=0.8; P=0.04). Finally, the endothelial cell layer was significantly thicker in the @entity0 with HMB-E than in the control subjects. Thus, the upregulation of @entity1 in idiopathic HMB-E is associated with a low pericyte coverage during the proliferative phase of intense angiogenesis, which may confer @entity4 , possibly leading to excessive @entity2 .

title: Low pericyte coverage of endometrial microvessels in heavy menstrual @entity3 correlates with the microvessel expression of XXXX .

answer: @entity1