abstract: OBJECTIVE: @entity5 kinase inhibitors (TKIs) of the @entity4 ( @entity4 ) have been reported to be effective in the treatment of esophageal and esophagogastric junction @entity1 . The aim of this study was to detect the frequency of @entity4 mutation and expression in Chinese @entity0 with esophageal, esophagogastric junction and @entity2 , and to clarify the value of @entity4 mutation and expression in predicting the efficacy of TKI in the treatment of these @entity1 . METHODS: In this study, 180 @entity1 samples with histologically confirmed @entity3 (39 cases), @entity1 of the esophagogastric junction (92 cases) and @entity2 (49 cases) were collected. Twenty-nine different @entity4 mutations in exons 18-21 were assessed by real-time PCR-optimized oligonucleotide probe method. @entity4 protein expression was evaluated by immunohistochemistry (IHC) in 89 @entity1 samples. RESULTS: The mutation analysis for @entity4 (exons 18-21) showed no mutations in any of the hotspots of the gene in the 180 @entity1 samples analyzed. @entity4 expression was negative in 12 @entity1 samples, 1+ in 31 @entity1 samples, 2+ in 24 @entity1 samples, and 3+ in 22 @entity1 samples. @entity4 expression was 2+ or 3+ in 12 (92.3%) of the 13 esophageal @entity6 , 29 (47.5%) of the 61 esophagogastric junction @entity1 , and 5 (33.3%) of the 15 @entity2 . CONCLUSIONS: Our results indicate that @entity4 mutation in exons 18-21 is absent in the examined samples of esophageal, esophagogastric junction and @entity2 . More studies are warranted to explore the predictive biological markers for the therapeutic response to @entity4 TKI.

title: [Detection and significance of @entity4 mutation in esophageal, esophagogastric junction and XXXX ].

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is one of the most common @entity2 in adults in both developing and developed countries. The etiology and pathogenesis of @entity2 remain poorly understood, and the disease is refractory to therapy in many @entity0 . Mast cell activation has been demonstrated in the sinonasal mucosa of @entity0 with @entity2 ; however, the specific contribution of mast cells to the development and pathogenesis of this disease has not been established. OBJECTIVE: The objective of this study was to investigate the role of mast cells in the development of @entity2 . METHODS: C57BL/6 wild-type and C57BL/6-Kit(W-sh/W-sh) mast cell-deficient @entity1 were immunized by intraperitoneal allergen injection and subsequent chronic low dose intranasal allergen challenges. The sinonasal phenotypes of these groups were then evaluated and compared to saline-treated controls using radiologic, histologic, and immunologic methods. RESULTS: Wild-type @entity1 exposed to chronic intranasal allergen developed many features seen in @entity0 @entity2 , including mucosal thickening, cystic changes, polyp development, @entity4 , @entity3 , and mast cell activation. In contrast, sinonasal pathology was significantly attenuated in mast cell-deficient @entity1 subjected to the same chronic allergen protocol. Specifically, tissue @entity4 and @entity3 were reduced by approximately 50% compared to wild-type levels. Surprisingly, none of the mast cell-deficient @entity1 subjected to chronic allergen challenge developed cystic changes or polypoid changes in the nose or sinuses. CONCLUSIONS: These data identify a critical role for mast cells in the development of many features of a @entity1 model of @entity4 , suggesting that therapeutic strategies targeting mast cells be examined in @entity0 afflicted with this disease.

title: Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in XXXX .

answer: @entity1


abstract: PURPOSE: The purpose of this study was to develop evidence-based guidelines on @entity2 management via the web and to examine the effects in terms of @entity1 level of @entity0 undergoing abdominal surgery and nurses' knowledge of @entity2 management. METHODS: First, evidence-based @entity1 guidelines were developed via the web in a tertiary hospital. Second, a special educational program on evidence-based @entity1 guidelines for nurses was developed after validation of content by experts. Third, diverse strategies were adopted in order to facilitate incorporation of evidence-based @entity1 guidelines in practice. Fourth, nurses in the study units were educated on evidence-based guidelines using the developed educational program for 3 weeks before their implementation of evidence-based @entity1 guidelines to @entity0 . @entity0 were assigned to the control group (from July 29 to August 20, 2011) and the experimental group (from September 24 to October 25, 2011) according to interrupted time interval. The data were analyzed using chi-square test, analysis of variance test with Scheff  's test as a post hoc and repeated measure of analysis of variance. RESULTS: @entity0 in the experimental group showed a significantly lower level of @entity1 . Nurses' knowledge of management of @entity2 showed a significant increase after installation of evidence-based guidelines. CONCLUSION: Evidence-based @entity1 guidelines were effective in reducing the @entity1 level of @entity0 as well as improving nurses' knowledge of @entity1 management.

title: Effect of evidence-based XXXX guidelines via web for @entity0 undergoing abdominal surgery in South Korea.

answer: @entity2


abstract: PURPOSE: The purpose of this study was to develop evidence-based guidelines on @entity2 management via the web and to examine the effects in terms of @entity1 level of @entity0 undergoing abdominal surgery and nurses' knowledge of @entity2 management. METHODS: First, evidence-based @entity1 guidelines were developed via the web in a tertiary hospital. Second, a special educational program on evidence-based @entity1 guidelines for nurses was developed after validation of content by experts. Third, diverse strategies were adopted in order to facilitate incorporation of evidence-based @entity1 guidelines in practice. Fourth, nurses in the study units were educated on evidence-based guidelines using the developed educational program for 3 weeks before their implementation of evidence-based @entity1 guidelines to @entity0 . @entity0 were assigned to the control group (from July 29 to August 20, 2011) and the experimental group (from September 24 to October 25, 2011) according to interrupted time interval. The data were analyzed using chi-square test, analysis of variance test with Scheff  's test as a post hoc and repeated measure of analysis of variance. RESULTS: @entity0 in the experimental group showed a significantly lower level of @entity1 . Nurses' knowledge of management of @entity2 showed a significant increase after installation of evidence-based guidelines. CONCLUSION: Evidence-based @entity1 guidelines were effective in reducing the @entity1 level of @entity0 as well as improving nurses' knowledge of @entity1 management.

title: Effect of evidence-based @entity2 guidelines via web for XXXX undergoing abdominal surgery in South Korea.

answer: @entity0


abstract: OBJECTIVE: To evaluate the outcomes and the prognostic factors for advanced @entity1 after concurrent chemoradiotherapy (CCRT). METHODS: Totally 172 @entity0 with International Federation of Gynecology and Obstetrics stage IIb-IV who were treated in Cancer Hospital, Chinese Academy of Medical Sciences between January 2007 and December 2008 were retrospectively analyzed. @entity0 were received external radiotherapy, high-dose rate brachytherapy and @entity2 -based chemotherapy concurrently. RESULTS: The median follow-up period was 54.5 months. The 2-year and 5-year @entity4 ( @entity4 ) were separately 81.5% and 68.8%. The 2-year and 5-year progress-free survival (PFS) were separately 69.2% and 63.1%. Using univariate analysis followed with multivariate analysis, the results showed that these clinicopathological factors including stage (III and above versus IIb; P = 0.021, HR = 1.95; P = 0.020, HR = 1.86), maximum diameter of local @entity1 size (>4 versus  <= 4 cm; P = 0.009, HR = 2.55; P = 0.033, HR = 1.94), @entity3 antigen ( @entity5 ) level before treatment (>3 versus  <= 3   g/L; P = 0.010, HR = 2.47; P = 0.013, HR = 2.09) and retroperitoneal lymph node status on imaging (para-aortic lymph node positive versus negative, P = 0.009, HR = 3.00, P = 0.010, HR = 2.74; pelvic lymph node positive only versus negative, P = 0.044, HR = 1.98, P = 0.033, HR = 1.92) had the significant effect on @entity4 and PFS. @entity0 with no above adverse prognostic factor were assigned to Group A (n = 18), those with one factor were assigned to Group B (n = 43), and those with no less than two factors were assigned to Group C (n = 111). Among three groups, the 2-year @entity4 were separately 94.1%, 97.7% and 73.1%, the 5-year @entity4 were separately 81.4%, 90.1% and 58.6%, the 2-year PFS were separately 88.2%, 90.4% and 57.9%, the 5-year PFS were 82.4%, 87.9% and 50.0%. The results showed that group C was significant difference from Group A or B in @entity4 and PFS (all P < 0.05), while Group A had no significant difference from Group B in @entity4 and PFS (P > 0.05). CONCLUSIONS: Stage III or above, maximum diameter of local @entity1 size >4 cm, @entity5 level >3   g/L before treatment and positive retroperitoneal lymph nodes on imaging are four independent adverse factors for prognosis of @entity1 of advanced stage after CCRT. The treatment of @entity0 with no less than two adverse factors should be considered to be improved.

title: [Outcomes and prognostic factors of advanced XXXX after concurrent chemoradiotherapy].

answer: @entity1


abstract: BACKGROUND AND AIMS: Perioperative @entity2 are a significant cause of post-operative morbidity in @entity0 undergoing prolonged procedures. The aims of this study were to determine the incidence and possible causes of @entity2 in @entity0 undergoing abdominal free flap breast reconstruction and to develop methods of ameliorating this problem. METHODS: A 4-year retrospective study of @entity0 undergoing abdominal free flap breast reconstruction by a single surgeon and anaesthetist was undertaken to determine the incidence and potential causes of perioperative @entity1 . A new positioning protocol was introduced to minimise the stretch on the brachial plexus and to protect peripheral nerves from compression forces. In addition, regular intraoperative physiotherapy was introduced. A prospective study was then conducted on @entity0 managed by the same team to evaluate the effect of this change in practice on the subsequent incidence of @entity2 . RESULTS: Over the 4-year retrospective period, 93 consecutive @entity0 underwent abdominal free flap breast reconstruction, six of whom (6.5%) developed a @entity2 . Following the introduction of the new positioning protocol, prospective data collected on 65 consecutive @entity0 showed no further occurrences of perioperative @entity1 (p  =  0.04). There were no significant differences in the characteristics between the two cohorts. CONCLUSION: Perioperative @entity2 in abdominal free flap breast reconstruction is a preventable problem. This paper presents a @entity2 prevention protocol for managing these @entity0 .

title: Prevention of perioperative limb XXXX in abdominal free flap breast reconstruction.

answer: @entity1


abstract: OBJECTIVE: To study the role of mitogen-activated protein kinases (MAPKs) in @entity0 annulus fibrosus (AF) cells subjected to @entity7 ( @entity7 ). DESIGN: An in  vitro system for @entity7 studies was established using AF cultures on fibronectin-coated @entity4 dishes. MAPK phosphorylation was studied by western analysis, while gene expression was followed by qRT-PCR. DNA synthesis was assessed by both tritiated @entity3 incorporation and flow cytometry, and collagen synthesis using tritiated @entity6 incorporation and the protease-free collagenase method. RESULTS: All three MAPKs studied, i.e., ERK, SAPK/JNK, and @entity5 were found to be phosphorylated immediately after @entity7 application within physiological range. A second wave of phosphorylation appeared at later time points. MAPK activation was elevated at higher @entity7 magnitudes, but independent of the frequency. @entity7 did not stimulate DNA synthesis neither extracellular matrix turnover, but it stimulated the proinflammatory genes, @entity8 , @entity1 , and @entity2 . This stimulation was more intense at the highest magnitude (8%) tested  and at the median frequency (1  Hz) and time interval (12  h). Blocking of ERK, SAPK/JNK, and @entity5 MAPK inhibited the @entity7 -induced stimulation of @entity8 and @entity2 , while @entity1 expression was mediated only by SAPK/JNK and @entity5 MAPK. CONCLUSIONS: We have described for the first time the activation of MAPKs in @entity0 AF cells in response to @entity7  and showed that it drives an inflammatory reaction. These observations shed light on the mechanisms of intervertebral disc (IVD) cell responses to mechanical stress, contributing to the understanding of disc pathophysiology  and possibly to the design of novel therapeutic interventions.

title: Cyclic tensile stress of XXXX annulus fibrosus cells induces MAPK activation: involvement in proinflammatory gene expression.

answer: @entity0


abstract: PURPOSE: An ultrasonic resorbable @entity4 (SonicWeld, KLS Martin, M  hlheim, Germany) was compared with hyaluronic acid (Hyaloss Matrix, Anika Therapeutics, Bedford, MA) for their ability to maintain space in non-grafted sinus lifting. MATERIALS AND METHODS: A comparative split-mouth study was designed and implemented. Six @entity0 and 4 @entity0 were included (mean age, 56.7  yr). The primary predictors hyaluronic acid (HA) application and ultrasonic resorbable @entity4 fixation (URPF) were coded as binary variables. The primary outcome variables were height of @entity2 ( @entity3 ). Secondary outcomes were bone density and implant survival. RESULTS: The postoperative mean @entity2 was significantly higher than the preoperative mean @entity2 on the 2 sides (P < .05). Mean increases in @entity2 and @entity3 on the URPF side were significantly greater than those on the HA side (P < .05). In total, @entity0 were treated with 40 implants. No type I bone quality was identified; 14 (35%) implants were inserted in type II bone, 22 (50%) in @entity1 (15%) in type IV bone. There was no statistically meaningful difference between the 2 sides for implant survival or bone quality. At 6  months, all implants were clinically stable and the definitive prostheses were functional, resulting in a survival rate of 100%. CONCLUSIONS: There was sufficient bone height to eventually place implants on the 2 sides in all @entity0 . The 2 techniques yielded predictable outcomes in implant survival and bone quality. However, @entity2 and @entity3 were considerably greater on the URPF side.

title: Hyaluronic Acid Versus Ultrasonic Resorbable XXXX Fixation for Space Maintenance in Non-Grafted Sinus Lifting.

answer: @entity4


abstract: UNASSIGNED: Accurate prediction of the metabolic energy walking requires can inform numerous health, bodily status and fitness outcomes. Here, we adopted a two-step approach to identifying a concise, generalized equation for predicting level @entity0 walking metabolism. Using literature-aggregated values, we compared: 1) the predictive accuracy of three literature equations: ACSM, Pandolf, and @entity1 ( @entity1 ) equations, and 2) the goodness-of-fit possible from one- vs. two-component descriptions of walking metabolism. Literature metabolic rate values (n=127; speed range=0.4-1.9 m   s(-1)) were aggregated from 25 subject populations (n=5-42) whose means spanned a 1.8-fold range of heights and a 4.2-fold range of weights. Population-specific resting metabolic rates (VO2-rest) were determined using standardized equations. Our first finding was that the ACSM and Pandolf equations under-predicted nearly all 127 literature-aggregated values. Consequently, their standard errors of estimate (SEE) were nearly four times greater than those of the @entity1 equation (4.51 and 4.39 vs. 1.13 mls O2   kg(-1)   min(-1), respectively). For our second comparison, empirical best-fit relationships for walking metabolism were derived from the data set in one- and two-component forms for three VO2-speed model types: linear (   V(1.0)), exponential (   V(2.0)), and exponential/height (   V(2.0)/Ht). We found that the proportion of variance (R(2)) accounted for, when averaged across the three model types, was substantially lower for one- vs. two-component versions (0.63  0.1 vs. 0.90  0.03) and the predictive errors were nearly twice as great (SEE=2.22 vs. 1.21 mls O2   kg(-1)   min(-1)). Our final analysis identified the following concise, generalized equation for predicting level @entity0 walking metabolism: VO2-total=VO2-rest+3.85+5.97   V(2)/Ht (units: V, m   s(-1); Ht, m; and VO2, mls @entity2   kg(-1)   min(-1)).

title: Energy expenditure during level XXXX walking: seeking a simple and accurate predictive solution.

answer: @entity0


abstract: PURPOSE: The aim of this study is to evaluate the safety and efficacy of percutaneous treatment of @entity1 after paediatric liver transplantation. MATERIALS AND METHODS: In the period between October 1999 and October 2010, a total of 92 transplants in 86 @entity0 were performed at our Liver Transplant Centre. Eighteen @entity0 had @entity1 (in four cases associated with intrahepatic @entity4 ). Percutaneous treatment (transhepatic biliary drainage and conventional/cutting balloon dilatation) was proposed as a first approach in 13/18 @entity0 . Strict radiation protection precautions were taken in accordance with the ALARA (as low as reasonably achievable) principle. Mean follow-up time was 2,364  days. RESULTS: Surgical correction was required in 3/13 @entity0 ; in 8/13 cases, there was complete disappearance of clinical symptoms without bile duct dilatation; in one case, an asymptomatic persistent bile duct dilatation was detected while in the other case, the liver is currently in @entity3 (69  % clinical success including the asymptomatic @entity0 with @entity2 ). Two of the five @entity0 who were initially treated with surgery required percutaneous revision (clinical success of 100  %). There were two cases of long-term restenosis and two cases of transient haemobilia. CONCLUSIONS: Percutaneous procedures are safe and effective therapeutic options for the treatment of @entity1 after paediatric liver transplantation.

title: The role of interventional radiology in the treatment of XXXX after paediatric liver transplantation.

answer: @entity1


abstract: Compressive symptoms due to @entity2 and @entity6 have been shown to be associated with increased perioperative morbidity. However, little is known about the risk associated with the surgical management of @entity0 presenting with cervical @entity3 secondary to @entity2 . A retrospective review of data of @entity0 undergoing thyroid surgery in a tertiary referral center was performed. The outcomes of @entity0 with @entity3 due to @entity2 were compared to those of @entity0 without @entity3 . 886 @entity0 operated upon between 2005 and 2012 were included for analysis. 284 cases with @entity3 (study group) were compared to 602 cases without @entity3 (control group). There was no difference in the duration of surgery among both groups (123 vs. 126  min, p  =  0.75). There was no significant difference among both groups with regard to postoperative @entity5 (1.4 vs. 1.1  %), rate of recurrent @entity4 (6.3 vs. 7.2  %) and @entity1 (2.1 vs. 3.1  %). Compressive symptoms resolved in a significant number of @entity0 following surgery. There was no significant difference in postoperative outcome between @entity0 with and without @entity3 . Therefore, cervical compression due to @entity2 is not associated with increased perioperative morbidity.

title: Cervical compression due to XXXX is not associated with increased postoperative morbidity.

answer: @entity2


abstract: BACKGROUND: Bone cement implantation syndrome (BCIS) is characterized by @entity2 , @entity3 , and @entity4 occurring around the time of bone cementation. Using a recently proposed severity classification of BCIS, we estimated the incidence of and risk factors for BCIS and its impact on mortality in cemented hemiarthroplasty for @entity7 . METHODS: In this retrospective study, 1016 @entity0 undergoing cemented hemiarthroplasty were included. Medical history and medication were obtained from medical records. Anaesthesia charts for all @entity0 were reviewed for mean arterial pressure, arterial @entity1 saturation, and heart rate before, during, and after cementation. Each @entity0 was classified as having no BCIS (grade 0) or BCIS grade 1, 2, or 3, depending on the degree of @entity3 , arterial desaturation, or @entity4 around cementation. RESULTS: The incidence of BCIS grade 1, 2, and 3 were 21%, 5.1%, and 1.7%, respectively. Early mortality in BCIS grade 1 (9.3%) did not differ significantly from BCIS grade 0 (5.2%), while early mortality in BCIS grade 2 (35%) and grade 3 (88%) were significantly higher when compared with grades 0 and 1. Early mortality was also higher in BCIS grade 3 when compared with grade 2. Independent predictors for severe BCIS were: ASA grade III-IV, @entity5 , and medication with diuretics or @entity6 . Severe BCIS was associated with 16-fold increase in mortality. CONCLUSIONS: BCIS is a commonly occurring phenomenon in cemented hemiarthroplasty and severe BCIS has a huge impact on early and late mortality.

title: Bone cement implantation syndrome in cemented hemiarthroplasty for XXXX : incidence, risk factors, and effect on outcome.

answer: @entity7


abstract: BACKGROUND: Endoscopic resection is increasingly used to treat localized, early-stage @entity3 . We sought to assess its adoption, characterize the risks of nodal metastases, and define differences in procedural mortality and 5-year survival between endoscopic and surgical resection in the United States. METHODS: From the National Cancer Data Base, @entity0 with T1a and T1b lesions were identified. Treatment patterns were characterized, and hierarchical regression methods were used to define predictors and evaluate outcomes. All statistical tests were two-sided. RESULTS: Five thousand three hundred ninety @entity0 were identified and underwent endoscopic (26.5%) or surgical resection (73.5%). Endoscopic resection increased from 19.0% to 53.0% for T1a lesions (P < .001) and from 6.6% to 20.9% for T1b @entity2 (P < .001). The strongest predictors of endoscopic resection were depth of invasion (T1a vs T1b: odds ratio [OR] = 4.45; 95% confidence interval [CI] = 3.76 to 5.27) and @entity0 age of 75 years or older (vs age less than 55 years: OR = 4.86; 95% CI = 3.60 to 6.57). Among @entity0 undergoing surgery, lymph node @entity1 was 5.0% for T1a and 16.6% for T1b lesions. Predictors of nodal metastases included @entity2 size greater than 2 cm (vs. <2 cm) and intermediate-/high-grade lesions (vs low grade). For example, 0.5% of @entity0 with low-grade T1a lesions less than 2 cm had lymph node involvement. The risk of 30-day mortality was less after endoscopic resection (hazard ratio [HR] = 0.33; 95% CI = 0.19 to 0.58) but greater for conditional 5-year survival (HR = 1.63; 95% CI = 1.07 to 2.47). CONCLUSIONS: Endoscopic resection has become the most common treatment of T1a @entity3 and has increased for T1b @entity2 . It remains important to balance the risk of nodal metastases and procedural risk when counseling @entity0 regarding their treatment options.

title: Treatment trends, risk of lymph node @entity1 , and outcomes for localized XXXX .

answer: @entity3


abstract: BACKGROUND: Endoscopic resection is increasingly used to treat localized, early-stage @entity3 . We sought to assess its adoption, characterize the risks of nodal metastases, and define differences in procedural mortality and 5-year survival between endoscopic and surgical resection in the United States. METHODS: From the National Cancer Data Base, @entity0 with T1a and T1b lesions were identified. Treatment patterns were characterized, and hierarchical regression methods were used to define predictors and evaluate outcomes. All statistical tests were two-sided. RESULTS: Five thousand three hundred ninety @entity0 were identified and underwent endoscopic (26.5%) or surgical resection (73.5%). Endoscopic resection increased from 19.0% to 53.0% for T1a lesions (P < .001) and from 6.6% to 20.9% for T1b @entity2 (P < .001). The strongest predictors of endoscopic resection were depth of invasion (T1a vs T1b: odds ratio [OR] = 4.45; 95% confidence interval [CI] = 3.76 to 5.27) and @entity0 age of 75 years or older (vs age less than 55 years: OR = 4.86; 95% CI = 3.60 to 6.57). Among @entity0 undergoing surgery, lymph node @entity1 was 5.0% for T1a and 16.6% for T1b lesions. Predictors of nodal metastases included @entity2 size greater than 2 cm (vs. <2 cm) and intermediate-/high-grade lesions (vs low grade). For example, 0.5% of @entity0 with low-grade T1a lesions less than 2 cm had lymph node involvement. The risk of 30-day mortality was less after endoscopic resection (hazard ratio [HR] = 0.33; 95% CI = 0.19 to 0.58) but greater for conditional 5-year survival (HR = 1.63; 95% CI = 1.07 to 2.47). CONCLUSIONS: Endoscopic resection has become the most common treatment of T1a @entity3 and has increased for T1b @entity2 . It remains important to balance the risk of nodal metastases and procedural risk when counseling @entity0 regarding their treatment options.

title: Treatment trends, risk of lymph node XXXX , and outcomes for localized @entity3 .

answer: @entity1


abstract: UNASSIGNED: Conventional @entity2 markers have limited value for prognostication and treatment monitoring in @entity0 ( @entity0 ) @entity1 and novel circulating @entity2 markers therefore need to be explored. Hyaluronic acid (HA) is a major macropolysaccharide in the extracellular matrix and is reported to be associated with @entity2 progression. In our study, we investigated plasma HA level with respect to progression free survival (PFS) and @entity3 ( @entity3 ), as well as the treatment monitoring value in @entity0 @entity1 . The prognostic value of plasma HA level was investigated in a discovery cohort of 212 @entity0 @entity1 with 2.5-year follow-up and validated in an independent validation cohort of 334 @entity1 with 5-year follow-up. The treatment monitoring value of plasma HA level was investigated in 61 @entity0 @entity1 from discovery cohort who had been radiographically examined after 1(st) complete cycle of chemo therapy. We found a robust association between high plasma HA level and poor prognosis of @entity0 @entity1 in both discovery (pPFS = 7.92 * 10(-6) and pOS = 5.27 * 10(-5) ) and validation studies (pPFS = 3.66 * 10(-4) andpOS = 1.43 * 10(-4) ). In the discovery cohort, the plasma HA level displayed independent prognostic value after adjusted for age and clinicopathological factors, with respect to PFS and @entity3 . Further, the decrease of plasma HA level displayed good concordance with treatment response evaluated by radiographic examination (AUC=0.79). Plasma HA level displays prognostic value, as well as treatment monitoring value for @entity0 @entity1 . This article is protected by copyright. All rights reserved.

title: Plasma Hyaluronic Acid level as a Prognostic and Monitoring Marker of Metastatic XXXX .

answer: @entity0


abstract: BACKGROUND: Primary @entity1 of the central nervous system (CNS) are uncommon; @entity8 in this region are extremely rare. Very few cases of amelanotic variation of primary @entity4 in the CNS were reported on. General guidelines or recommendations to establish this diagnosis do not exist. CASE REPORT: A sixty-year-old male Hispanic @entity0 presented with a 7-day history of @entity6 and @entity7 . Initial laboratory work-up and physical examination were inconclusive. Cerebral radiological imaging showed a @entity2 . Further work-up after clinical deterioration revealed an increase in the lesion size consistent with @entity5 and changes in T1WI. Biopsy and immunochemistry demonstrated the presence of @entity8 in the CNS without evidence of another @entity2 . CONCLUSIONS: Primary @entity3 represents a challenge, clinically and diagnostically. Magnetic resonance imaging can be helpful in early stages. Final diagnosis is established with immunohistochemical testing. Physicians should be aware of the existence of this rare manifestation and difficulties faced while building this diagnosis.

title: Primary central nervous system XXXX in a Hispanic male: Case report.

answer: @entity8


abstract: STUDY DESIGN: Test-retest design OBJECTIVE.: The objective was to examine the intra-rater (test-retest) reliability of the core stability related tests and to develop a reliable core stability assessment battery. SUMMARY OF BACKGROUND DATA: Studies suggest that core stability exercises may improve function and decrease @entity1 in @entity0 with non-specific @entity3 ( @entity3 ). Reliable clinical tests are required to implement adequate rehabilitation and to evaluate results of these interventions. METHODS: The study had a test-retest design. Thirty-three different tests that might relate to core stability were identified with their mostly used protocols. Five different components of core stability including endurance, flexibility, strength, functional performance, and motor control were assessed in 38 @entity0 with non-specific @entity3 . The same testing procedure was performed again after 48-72hours. Intra-class correlation coefficients (ICCs), standard error of measurement, and minimal detectable change were calculated to assess the intra-rater reliability. RESULTS: The intra-rater reliability of the tests ranged from little to very high (ICC=0.08-0.98). Partial curl-up (ICC=0.90), lateral bridge (ICC=0.95-0.96), trunk flexor endurance (ICC=0.97), sit-and-reach (ICC=0.98), single-legged hop (ICC=0.98-0.97), lateral step-down (ICC=0.93-0.92), @entity2 and left leg unilateral stance (ICC=0.97 and 0.91) tests had the highest intra-rater reliability for each core stability component. CONCLUSIONS: The results indicated that the partial curl-up test (strength), side bridge and trunk flexor tests (endurance), sit-and-reach test (flexibility), single-legged hop, and lateral step-down (functional), unilateral stance test with eyes open (motor control) had very high intra-rater reliability. A core stability assessment battery involving these tests can be used in @entity0 with non-specific @entity3 to assess all components of core stability. LEVEL OF EVIDENCE: 3.

title: Developing a Reliable core Stability Assessment Battery for @entity0 With non-Specific Low Back XXXX .

answer: @entity1


abstract: STUDY DESIGN: Test-retest design OBJECTIVE.: The objective was to examine the intra-rater (test-retest) reliability of the core stability related tests and to develop a reliable core stability assessment battery. SUMMARY OF BACKGROUND DATA: Studies suggest that core stability exercises may improve function and decrease @entity1 in @entity0 with non-specific @entity3 ( @entity3 ). Reliable clinical tests are required to implement adequate rehabilitation and to evaluate results of these interventions. METHODS: The study had a test-retest design. Thirty-three different tests that might relate to core stability were identified with their mostly used protocols. Five different components of core stability including endurance, flexibility, strength, functional performance, and motor control were assessed in 38 @entity0 with non-specific @entity3 . The same testing procedure was performed again after 48-72hours. Intra-class correlation coefficients (ICCs), standard error of measurement, and minimal detectable change were calculated to assess the intra-rater reliability. RESULTS: The intra-rater reliability of the tests ranged from little to very high (ICC=0.08-0.98). Partial curl-up (ICC=0.90), lateral bridge (ICC=0.95-0.96), trunk flexor endurance (ICC=0.97), sit-and-reach (ICC=0.98), single-legged hop (ICC=0.98-0.97), lateral step-down (ICC=0.93-0.92), @entity2 and left leg unilateral stance (ICC=0.97 and 0.91) tests had the highest intra-rater reliability for each core stability component. CONCLUSIONS: The results indicated that the partial curl-up test (strength), side bridge and trunk flexor tests (endurance), sit-and-reach test (flexibility), single-legged hop, and lateral step-down (functional), unilateral stance test with eyes open (motor control) had very high intra-rater reliability. A core stability assessment battery involving these tests can be used in @entity0 with non-specific @entity3 to assess all components of core stability. LEVEL OF EVIDENCE: 3.

title: Developing a Reliable core Stability Assessment Battery for XXXX With non-Specific Low Back @entity1 .

answer: @entity0


abstract: AIMS: To better understand the genetic ontogeny of @entity3 of @entity4 , we analyzed telomerase reverse transcriptase ( @entity5 ) promoter mutation status in a group of 26 @entity3 in comparison with the mutation status of @entity2 with inverted growth (26 cases), conventional @entity2 (36 Ta noninvasive @entity2 , 35 T2 invasive @entity2 ), and @entity6 (25 cases). METHODS AND RESULTS: @entity5 promoter mutations in @entity3 , @entity2 with inverted growth, @entity2 , and @entity6 were 15% (4/26), 58% (15/26), 63% (45/71), and 0% (0/25), respectively. @entity7 mutations were the predominant mutations (97%) found in @entity1 while @entity8 aberrations occurred in only about 3% of @entity1 . In the @entity3 group, @entity5 mutation occurred predominantly in female @entity0 (P=0.006). Among @entity2 , @entity5 promoter mutation status did not correlate with gender, histologic grade or pathologic stage. CONCLUSIONS: @entity5 promoter mutations were found in 15% of @entity3 . Our data suggest that there is a subpopulation of @entity3 that shares a carcinogenetic pathway with @entity2 with inverted growth and conventional @entity2 . Caution is warranted in exploring @entity5 promoter mutation status as a screening or adjunct diagnostic test for @entity1 . This article is protected by copyright. All rights reserved.

title: Telomerase reverse transcriptase ( XXXX ) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of @entity3 with immortalizing genetic change.

answer: @entity5


abstract: AIMS: To better understand the genetic ontogeny of @entity3 of @entity4 , we analyzed telomerase reverse transcriptase ( @entity5 ) promoter mutation status in a group of 26 @entity3 in comparison with the mutation status of @entity2 with inverted growth (26 cases), conventional @entity2 (36 Ta noninvasive @entity2 , 35 T2 invasive @entity2 ), and @entity6 (25 cases). METHODS AND RESULTS: @entity5 promoter mutations in @entity3 , @entity2 with inverted growth, @entity2 , and @entity6 were 15% (4/26), 58% (15/26), 63% (45/71), and 0% (0/25), respectively. @entity7 mutations were the predominant mutations (97%) found in @entity1 while @entity8 aberrations occurred in only about 3% of @entity1 . In the @entity3 group, @entity5 mutation occurred predominantly in female @entity0 (P=0.006). Among @entity2 , @entity5 promoter mutation status did not correlate with gender, histologic grade or pathologic stage. CONCLUSIONS: @entity5 promoter mutations were found in 15% of @entity3 . Our data suggest that there is a subpopulation of @entity3 that shares a carcinogenetic pathway with @entity2 with inverted growth and conventional @entity2 . Caution is warranted in exploring @entity5 promoter mutation status as a screening or adjunct diagnostic test for @entity1 . This article is protected by copyright. All rights reserved.

title: Telomerase reverse transcriptase ( @entity5 ) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of XXXX with immortalizing genetic change.

answer: @entity3


abstract: @entity5 ( @entity6 ) are the most common @entity4 of the digestive tract. Approximately two thirds of clinically manifest @entity1 occur in the @entity8 , nearly one third in the small bowel, and the rest in the colorectal region with a few cases in the esophagus. @entity6 originate within the smooth muscle layer in the wall of the tubular gastrointestinal tract and grow mostly toward the serosa, far less often toward the mucosa. In the latter case, @entity7 may develop and can cause @entity3 as the cardinal symptom. However, most @entity6 are asymptomatic. They are increasingly detected incidentally as small intramural or @entity1 during endoscopy and particularly during endoscopic ultrasound. Epidemiological and molecular genetic findings suggest that early asymptomatic @entity6 (< 1 cm) show self-limiting tumorigenesis. Thus, early (< 1 cm) asymptomatic @entity2 (synonym: @entity6 ) are found in 20%-30% of the elderly. The mostly elderly @entity0 with early @entity2 have an excellent @entity6 -specific prognosis. @entity0 with early @entity6 can therefore be managed by endoscopic surveillance.

title: Management of early asymptomatic XXXX of the @entity8 .

answer: @entity5


abstract: @entity5 ( @entity6 ) are the most common @entity4 of the digestive tract. Approximately two thirds of clinically manifest @entity1 occur in the @entity8 , nearly one third in the small bowel, and the rest in the colorectal region with a few cases in the esophagus. @entity6 originate within the smooth muscle layer in the wall of the tubular gastrointestinal tract and grow mostly toward the serosa, far less often toward the mucosa. In the latter case, @entity7 may develop and can cause @entity3 as the cardinal symptom. However, most @entity6 are asymptomatic. They are increasingly detected incidentally as small intramural or @entity1 during endoscopy and particularly during endoscopic ultrasound. Epidemiological and molecular genetic findings suggest that early asymptomatic @entity6 (< 1 cm) show self-limiting tumorigenesis. Thus, early (< 1 cm) asymptomatic @entity2 (synonym: @entity6 ) are found in 20%-30% of the elderly. The mostly elderly @entity0 with early @entity2 have an excellent @entity6 -specific prognosis. @entity0 with early @entity6 can therefore be managed by endoscopic surveillance.

title: Management of early asymptomatic @entity5 of the XXXX .

answer: @entity8


abstract: BACKGROUND: Combined @entity2 ( @entity2 ) and @entity4 ( @entity4 ) is highly lethal. In a nonsurvival model of @entity2 + @entity4 , addition of high-dose @entity5 ( @entity7 ) (300 mg/kg) to hetastarch reduced @entity1 size and associated swelling 6 hours after injury; whether this would have translated into better neurologic outcomes remains unknown. It is also unclear whether lower doses of @entity7 would be neuroprotective. We hypothesized that addition of low-dose @entity7 to normal saline (NS) resuscitation would result in improved long-term neurologic recovery and decreased @entity1 size. METHODS: @entity2 was created in anesthetized @entity6 (40-43 kg) by controlled cortical impact, and volume-controlled @entity4 (40% volume) was induced concurrently. After 2 hours of shock, animals were randomized (n = 5 per group) to NS (3* shed blood) or NS + @entity7 (150 mg/kg). Six hours after resuscitation, packed red blood cells were transfused, and animals were recovered. Peripheral blood mononuclear cells were analyzed for acetylated histone-H3 at @entity3 -9. A Neurological Severity Score (NSS) was assessed daily for 30 days. Brain magnetic resonance imaging was performed on Days 3 and 10. Cognitive performance was assessed by training animals to retrieve food from color-coded boxes. RESULTS: There was a significant increase in histone acetylation in the NS + @entity7 -treated animals compared with NS treatment. The NS + @entity7 group demonstrated significantly decreased @entity0 and faster speed of recovery as well as smaller @entity1 size compared with the NS group. Although the final cognitive function scores were similar between the groups, the @entity7 -treated animals reached the goal significantly faster than the NS controls. CONCLUSION: In this long-term survival model of @entity2 + @entity4 , addition of low-dose @entity7 to saline resuscitation resulted in attenuated @entity0 , faster neurologic recovery, smaller @entity1 size, and a quicker normalization of cognitive functions.

title: Addition of low-dose @entity5 to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined XXXX and @entity4 .

answer: @entity2


abstract: BACKGROUND: Combined @entity2 ( @entity2 ) and @entity4 ( @entity4 ) is highly lethal. In a nonsurvival model of @entity2 + @entity4 , addition of high-dose @entity5 ( @entity7 ) (300 mg/kg) to hetastarch reduced @entity1 size and associated swelling 6 hours after injury; whether this would have translated into better neurologic outcomes remains unknown. It is also unclear whether lower doses of @entity7 would be neuroprotective. We hypothesized that addition of low-dose @entity7 to normal saline (NS) resuscitation would result in improved long-term neurologic recovery and decreased @entity1 size. METHODS: @entity2 was created in anesthetized @entity6 (40-43 kg) by controlled cortical impact, and volume-controlled @entity4 (40% volume) was induced concurrently. After 2 hours of shock, animals were randomized (n = 5 per group) to NS (3* shed blood) or NS + @entity7 (150 mg/kg). Six hours after resuscitation, packed red blood cells were transfused, and animals were recovered. Peripheral blood mononuclear cells were analyzed for acetylated histone-H3 at @entity3 -9. A Neurological Severity Score (NSS) was assessed daily for 30 days. Brain magnetic resonance imaging was performed on Days 3 and 10. Cognitive performance was assessed by training animals to retrieve food from color-coded boxes. RESULTS: There was a significant increase in histone acetylation in the NS + @entity7 -treated animals compared with NS treatment. The NS + @entity7 group demonstrated significantly decreased @entity0 and faster speed of recovery as well as smaller @entity1 size compared with the NS group. Although the final cognitive function scores were similar between the groups, the @entity7 -treated animals reached the goal significantly faster than the NS controls. CONCLUSION: In this long-term survival model of @entity2 + @entity4 , addition of low-dose @entity7 to saline resuscitation resulted in attenuated @entity0 , faster neurologic recovery, smaller @entity1 size, and a quicker normalization of cognitive functions.

title: Addition of low-dose XXXX to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined @entity2 and @entity4 .

answer: @entity5


abstract: BACKGROUND: Combined @entity2 ( @entity2 ) and @entity4 ( @entity4 ) is highly lethal. In a nonsurvival model of @entity2 + @entity4 , addition of high-dose @entity5 ( @entity7 ) (300 mg/kg) to hetastarch reduced @entity1 size and associated swelling 6 hours after injury; whether this would have translated into better neurologic outcomes remains unknown. It is also unclear whether lower doses of @entity7 would be neuroprotective. We hypothesized that addition of low-dose @entity7 to normal saline (NS) resuscitation would result in improved long-term neurologic recovery and decreased @entity1 size. METHODS: @entity2 was created in anesthetized @entity6 (40-43 kg) by controlled cortical impact, and volume-controlled @entity4 (40% volume) was induced concurrently. After 2 hours of shock, animals were randomized (n = 5 per group) to NS (3* shed blood) or NS + @entity7 (150 mg/kg). Six hours after resuscitation, packed red blood cells were transfused, and animals were recovered. Peripheral blood mononuclear cells were analyzed for acetylated histone-H3 at @entity3 -9. A Neurological Severity Score (NSS) was assessed daily for 30 days. Brain magnetic resonance imaging was performed on Days 3 and 10. Cognitive performance was assessed by training animals to retrieve food from color-coded boxes. RESULTS: There was a significant increase in histone acetylation in the NS + @entity7 -treated animals compared with NS treatment. The NS + @entity7 group demonstrated significantly decreased @entity0 and faster speed of recovery as well as smaller @entity1 size compared with the NS group. Although the final cognitive function scores were similar between the groups, the @entity7 -treated animals reached the goal significantly faster than the NS controls. CONCLUSION: In this long-term survival model of @entity2 + @entity4 , addition of low-dose @entity7 to saline resuscitation resulted in attenuated @entity0 , faster neurologic recovery, smaller @entity1 size, and a quicker normalization of cognitive functions.

title: Addition of low-dose @entity5 to saline resuscitation provides neuroprotection and improves long-term outcomes in a large animal model of combined @entity2 and XXXX .

answer: @entity4


abstract: Background   Ulnar impaction syndrome is a condition in which the ulna impacts on the ulnar carpus. This most commonly occurs when the ulna is longer than the radius, but it can also occur in wrists with ulnar neutral and ulnar negative variance. Materials and Methods   In this paper we outline our surgical technique for ulnar shortening osteotomy. A previously published retrospective case series of 28 @entity0 treated at our center is presented. Fifty consecutive @entity0 who underwent ulnar shortening osteotomy (USO) for @entity2 were approached for study, and 28 consented to review. Mean preoperative ulnar variance was +2.3   mm, and mean postoperative ulnar variance was -0.8 mm. Mean follow-up time was 21.2 months (8 to 41 months) and ten of 28 were receiving workers' compensation. Mean @entity1 score (visual analog scale; VAS) was 7.9. Univariate analysis was performed to assess clinical and demographic data. In addition, subgroup analysis of workers' compensation @entity0 and smokers was performed. Description of Technique   A longitudinal incision over the subcutaneous border of the ulna is used to expose the ulna between the distal and middle third of the ulna from the ulna styloid. Preoperative posteroanterior (PA) X-rays are reviewed to determine the amount of shortening required, with a goal of creating -2   mm variance postoperatively. A 6-hole dynamic compression plate is predrilled distally prior to performing two oblique osteotomies separated by the desired shortening length. The fragments are reduced, controlling for rotation, and plated using compression. In some cases, a lag screw is employed across the oblique osteotomy site. Results   Mean @entity1 scores were significantly reduced postoperatively (VAS 7.9 versus 3.1, P   <   0.0001). The mean Disabilities of the Arm, Shoulder, and Hand (DASH) score was 37.2 postoperatively. Flexion, extension, and supination were reduced compared with the contralateral unaffected extremity (84.6%, 85.3%, and 86.9% of normal). @entity0 receiving workers' compensation and smokers had significantly more @entity1 postoperatively (VAS 5.2 vs. 2.0, P   =   0.0002 and VAS 4.4 vs 2.4, P   <   0.05, respectively). Eleven of 28 @entity0 required hardware removal for plate irritation, and five of 28 @entity0 had a nonunion. Conclusion   We present our surgical technique for ulnar shortening osteotomy. @entity1 was significantly improved in our population; however, @entity0 receiving workers' compensation and smokers had less improvement in @entity1 and higher disability scores.

title: Ulnar shortening osteotomy for XXXX .

answer: @entity2


abstract: In revision total hip arthroplasty (THA), consensus is lacking regarding the optimal method for reconstruction of the most severe @entity3 . Porous @entity4 (TM) buttress augments were designed for the most severe postero-superior defects. The purpose of this study was to report the results of a consecutive series of acetabular reconstructions utilizing TM buttress augments. Eight complex acetabular reconstructions utilizing a TM buttress augment were performed at two centers. All were Paprosky 3A or Paprosky 3B @entity2 , with severe superior and posterior column deficiency where wedge augments were insufficient for mechanical support. The acetabular cup sizes ranged from 64-78, and a buttress shim was used in 7 of 8 cases. Clinical and radiographic follow-up averaged 16.5 months (range, 10-28) and no cases were lost to follow-up. There were no cases of clinical or radiographic loosening, and no case had required reoperation or revision. All @entity0 except one were ambulating with either no assist device or a single cane at final follow-up. There was one complication of an iliac wing @entity1 noted incidentally on postoperative x-rays in the lone @entity0 in whom a buttress shim was not used. At short-term follow-up, TM acetabular buttress augments appear to effectively substitute for the use of structural allografts or cages, which would otherwise be used in this challenging setting. The potential for biologic fixation is promising for the durability of these reconstructions; however, longer-term follow-up is required for full evaluation.

title: Porous XXXX Buttress Augments for Severe Acetabular Posterior Column Deficiency.

answer: @entity4


abstract: OBJECTIVE: To compare the @entity2 and developmental outcomes in @entity0 and young @entity0 with @entity1 who have undergone surgical and medical treatments. METHODS: An international, multicenter, observational cohort study was undertaken. A total of 317 @entity0 aged <6years, who had frequent disabling @entity2 despite intensive medical treatments, were registered. Among the enrolled @entity0 , 250 were treated medically (medical group), 31 underwent resective surgery (resective group), and 36 underwent palliative surgery [callosotomy (n=30) or vagal nerve stimulation (n=6); palliative group] on admission. @entity2 and developmental outcomes were obtained for 230 @entity0 during the 3-year follow-up period. Cox proportional hazard model was used to adjust for clinical backgrounds among treatment groups when comparing the @entity2 -free survival rates. RESULTS: At the 3-year follow-up, @entity2 -free survival was 15.7%, 32.1%, and 52.4% in the medical, palliative, and resective groups, respectively. The adjusted hazard ratios for @entity2 recurrence in the resective and palliative groups versus the medical group were 0.43 (95% CI, 0.21-0.87, P=0.019) and 0.82 (95% CI, 0.46-1.46, P=0.50), respectively; the former was statistically significant. Regarding the developmental outcome, the mean DQs in the resective group increased significantly compared to those in the medical group during the follow-up (P<0.01). As for subgroup analysis, better @entity2 and development outcomes were demonstrated in the resective group compared to the medical group in @entity0 with @entity1 (those to which no known @entity1 syndromes were applicable). SIGNIFICANCE: These results suggest that surgical treatments, particularly resective surgeries, are associated with better @entity2 and developmental outcomes compared with successive medical treatment. The present observations may facilitate the identification of @entity0 and young @entity0 with @entity1 who could benefit from surgery.

title: Surgical versus medical treatment for @entity0 with XXXX in infancy and early childhood: Results of an international multicenter cohort study in Far-East Asia (the FACE study).

answer: @entity1


abstract: OBJECTIVE: To compare the @entity2 and developmental outcomes in @entity0 and young @entity0 with @entity1 who have undergone surgical and medical treatments. METHODS: An international, multicenter, observational cohort study was undertaken. A total of 317 @entity0 aged <6years, who had frequent disabling @entity2 despite intensive medical treatments, were registered. Among the enrolled @entity0 , 250 were treated medically (medical group), 31 underwent resective surgery (resective group), and 36 underwent palliative surgery [callosotomy (n=30) or vagal nerve stimulation (n=6); palliative group] on admission. @entity2 and developmental outcomes were obtained for 230 @entity0 during the 3-year follow-up period. Cox proportional hazard model was used to adjust for clinical backgrounds among treatment groups when comparing the @entity2 -free survival rates. RESULTS: At the 3-year follow-up, @entity2 -free survival was 15.7%, 32.1%, and 52.4% in the medical, palliative, and resective groups, respectively. The adjusted hazard ratios for @entity2 recurrence in the resective and palliative groups versus the medical group were 0.43 (95% CI, 0.21-0.87, P=0.019) and 0.82 (95% CI, 0.46-1.46, P=0.50), respectively; the former was statistically significant. Regarding the developmental outcome, the mean DQs in the resective group increased significantly compared to those in the medical group during the follow-up (P<0.01). As for subgroup analysis, better @entity2 and development outcomes were demonstrated in the resective group compared to the medical group in @entity0 with @entity1 (those to which no known @entity1 syndromes were applicable). SIGNIFICANCE: These results suggest that surgical treatments, particularly resective surgeries, are associated with better @entity2 and developmental outcomes compared with successive medical treatment. The present observations may facilitate the identification of @entity0 and young @entity0 with @entity1 who could benefit from surgery.

title: Surgical versus medical treatment for XXXX with @entity1 in infancy and early childhood: Results of an international multicenter cohort study in Far-East Asia (the FACE study).

answer: @entity0


abstract: UNASSIGNED: Dystocias are common in dairy @entity0 and often adversely affect production, reproduction, animal welfare, labor, and economics within the dairy industry. An automated device that accurately predicts the onset of calving could potentially minimize the effect of @entity1 by enabling producers to intervene early. Although many well-documented indicators can detect the imminence of calving, research is limited on their effectiveness to predict calving when measured by automated devices. The objective of this experiment was to determine if a decrease in vaginal temperature (VT), @entity2 ( @entity2 ), and lying time (LT), or an increase in lying bouts (LB), as measured by 3 automated devices, could accurately predict the onset of calving within 24, 12, and 6 h. The combination of these 4 calving indicators was also evaluated. Forty-two multiparous Holstein @entity0 housed in tie-stalls were fitted with a temperature logger inserted in the vaginal cavity 7    2 d before their expected calving date; VT was recorded at 1-min intervals. An ear-attached sensor recorded @entity2 time every hour based on ear movement while an accelerometer fitted to the right hind leg recorded @entity0 position at 1-min intervals. On average, VT were 0.3    0.03  C lower, and @entity2 and LT were 41    17 and 52    28 min lower, respectively, on the calving day compared with the previous 4 @entity0 had 2    1 more LB on the calving day. Of the 4 indicators, a decrease in VT >=  0.1  C was best able to predict calving within the next 24 h with a sensitivity of 74%, specificity of 74%, positive and negative predictive values of 51 and 89%, and area under the curve of 0.80. Combining the indicators enhanced the performance to predict calving within the next 24, 12, and 6 h with best overall results obtained by combining the 3 devices for prediction within the next 24 h (sensitivity: 77%, specificity: 77%, positive and negative predictive values: 56 and 90%, area under the curve: 0.82). These results indicate that a device that could simultaneously measure these 4 calving indicators could not precisely determine the onset of calving, but the information collected would assist dairy farmers in monitoring the onset of calving.

title: Evaluation of calving indicators measured by automated monitoring devices to predict the onset of calving in Holstein dairy XXXX .

answer: @entity0


abstract: BACKGROUND: Mortality for refractory @entity4 remains high. In this @entity0 cohort, there have been mixed results in mechanical circulatory support device use as a bridge-to-decision therapy. We evaluated a continuous-flow external ventricular assist device (VAD), CentriMag VAD (Thoratec Corp., Pleasanton, CA), in @entity0 with various causes of refractory @entity4 . METHODS AND RESULTS: This is a retrospective review of adult @entity0 who underwent surgical CentriMag VAD insertion as bridge-to-decision therapy. From January 2007 through June 2012, 143 @entity0 received CentriMag VAD. The cause of refractory @entity4 was failure of medical management in 71 @entity0 , @entity5 in 37, graft failure post-heart transplantation in 22, and @entity1 post-implantable left VAD in 13. Mean age was 52  16 years, and 71% were in INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profile 1. Among 158 device runs, device configuration was BiVAD in 67%, isolated right VAD in 26%, and isolated left VAD in 8%. Median duration of support was 14 days (interquartile range, 8-26). Survival was 69% at 30 days and 49% at 1 year. The next destination after the CentriMag VAD was myocardial recovery in 30%, device exchange to an implantable VAD in 15%, and heart transplantation in 18%. The failure of medical management and the graft failure post-heart transplantation groups had higher 30-day survival compared with the @entity5 group. Major @entity2 events occurred in 33% and cerebrovascular accidents in 14%. There was no CentriMag pump failure or @entity3 . CONCLUSIONS: Bridge-to-decision therapy with CentriMag VAD is feasible in a variety of refractory @entity4 settings. @entity0 with @entity5 have inferior survival.

title: Bridge-to-decision therapy with a continuous-flow external ventricular assist device in refractory XXXX of various causes.

answer: @entity4


abstract: BACKGROUND: National data demonstrate minimal improvement in survival for @entity0 diagnosed with @entity1 despite a number of apparent advances during the past 3 decades. We wished to know how demographic characteristics, staging, therapy, and survival have changed over time for @entity0 with @entity1 who were accessioned to the @entity2 registry of a large community hospital in southern California. @entity0 AND METHODS: Clinical features and survival data were collected on @entity0 diagnosed during each of the successive 6-year eras of 1986 to 1991 (n = 812), 1992 to 1997 (n = 1072), 1998 to 2003 (n = 1209), and 2004 to 2009 (n = 1365). RESULTS: Median survival improved from 11 to 13 to 16 to 26 months and overall 5-year survival steadily improved from 16.5% to 19.1% to 24.0% to 31.1%. The proportion of @entity0 with @entity3 at diagnosis increased from 18.4% to 24.1% to 24.9% to 31.6%. Improvements in relative survival were much greater than have occurred nationally. Other obvious trends over time were increasing age of @entity0 , increasing proportions with diagnoses of @entity5 with concomitant decreases in squamous cell and small cell histologies, and decreases in the proportion of @entity4 with reciprocal increases in neuroendocrine diagnoses. The use of chemotherapy for @entity0 with @entity3 tripled in the most recent era. CONCLUSION: Survival has steadily improved for @entity0 in this community who were diagnosed with @entity1 . The explanations for this improvement are multifactorial, but include earlier stage at diagnosis, decreases in histologic types associated with active smoking, and increased use of systemic therapies.

title: Steadily improving survival in XXXX .

answer: @entity1


abstract: OBJECTIVE: To compare the initial clinical, biological, and radiographic findings of @entity3 by positivity for rheumatoid factor (RF) and/or anticyclic citrullinated peptide antibodies (anti-CCP), and to validate a @entity0 profile based on this serologic information. METHODS: The ESPOIR cohort comprises @entity0 presenting @entity2 of at least 2 joints for 6 weeks to 6 months. @entity0 underwent testing for IgM rheumatoid factor (IgM-RF) and anti- @entity5 antibodies and were divided into 4 groups: RF- and anti-CCP- (group 1), RF+ and anti-CCP- (group 2), RF- and anti-CCP+ (group 3), RF+ and anti-CCP+ (group 4). We compared the groups in terms of clinical, biological, and radiographic features (baseline scores and 6-month and 12-month progression). RESULTS: Of the 813 recruited @entity0 , 406 (50%) were in group 1, 91 (11.2%) in group 2, 34 (4.1%) in group 3, and 281 (34.6%) in group 4. Mean baseline erythrocyte sedimentation rate and @entity4 were higher for anti-CCP+ groups (groups 3 and 4) than for other groups (p < 0.001), and van der Heijde-modified Sharp score for radiographs was higher for group 4 than for other groups (p < 0.001). Clinical presentation was not consistently associated with serologic profile. Radiographic progression at 1 year was higher for anti-CCP+ groups than other groups (p < 0.001). CONCLUSION: The phenotype of @entity0 with @entity3 with or without anti-CCP and/or RF positivity did not correspond to a particular clinical presentation. However, baseline acute-phase reactants and short-term radiographic progression were high in patients with anti-CCP positivity, which may be associated with the inflammatory process and @entity1 in @entity0 with @entity3 .

title: Association of anticyclic citrullinated peptide antibodies and/or rheumatoid factor status and clinical presentation in XXXX : results from the ESPOIR cohort.

answer: @entity3


abstract: PURPOSE: The social needs of nursing home (NH) residents with @entity2 are often ignored even though they are capable of expressing their emotions and responding in social interactions. Insufficient social engagement in this population is known to be associated with low quality of life as well as many negative health outcomes, such as mortality, @entity4 , and functional decline. The purpose of this study was to identify the correlates of social engagement in NH residents with @entity2 . METHODS: The study used a descriptive, correlational design. A total of 153 older adults with @entity2 in 17 Iowa NHs participated in this study. Minimum Data Set for NH version 2.0 served as an outcome measure to evaluate social engagement, cognitive and physical functions, @entity3 , and behavioral symptoms. Demographic data were obtained from the @entity0 ' medical records. RESULTS: The findings indicated that no significant relationship was found between demographic characteristics and social engagement. There were significant and negative correlations between the degree of social engagement and the levels of @entity1 , activities of daily living impairment, @entity3 , and vision. Among these correlates, @entity3 was the most potent predictor of engagement. CONCLUSION: The study provided information about the correlates of social engagement in NH residents with @entity2 . Future research needs to be conducted to develop nursing interventions to involve these individuals in social activities tailored to functional levels, and @entity3 in more diverse geographic regions.

title: Correlates of social engagement in nursing home residents with XXXX .

answer: @entity2


abstract: Mutation is associated with developmental and @entity2 , aging, and @entity1 . While we understand some mutational processes operative in @entity0 disease, most remain mysterious. We used @entity7 whole-genome sequencing to model mutational signatures, analyzing 183 worm populations across 17 DNA repair-deficient backgrounds propagated for 20 generations or exposed to carcinogens. The baseline mutation rate in @entity7 was approximately one per genome per generation, not overtly altered across several DNA repair deficiencies over 20 generations. Telomere erosion led to complex chromosomal rearrangements initiated by breakage-fusion-bridge cycles and completed by simultaneously acquired, localized clusters of breakpoints. @entity9 induced substitutions of guanines in a GpC context, as observed in @entity10 -induced @entity3 . Mutational burden increased with impaired @entity4 excision repair. @entity5 and @entity8 , DNA crosslinking agents, caused dose- and genotype-dependent signatures among indels, substitutions, and rearrangements. Strikingly, both agents induced clustered rearrangements resembling "chromoanasynthesis," a replication-based mutational signature seen in constitutional genomic disorders, suggesting that interstrand crosslinks may play a pathogenic role in such events. @entity5 mutagenicity was most pronounced in xpf-1 mutants, suggesting that this gene critically protects cells against @entity6 chemotherapy. Thus, experimental model systems combined with genome sequencing can recapture and mechanistically explain mutational signatures associated with @entity0 disease.

title: XXXX whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency.

answer: @entity7


abstract: Purpose To evaluate the diagnostic performance of three-dimensional ( 3D three-dimensional ) quantitative enhancement-based and diffusion-weighted volumetric magnetic resonance (MR) imaging assessment of @entity3 ( @entity3 ) lesions in determining the extent of pathologic @entity2 ( @entity4 transarterial chemoembolization ). Materials and Methods This institutional review board-approved retrospective study included 17 @entity0 with @entity3 who underwent @entity4 transarterial chemoembolization before surgery. Semiautomatic 3D three-dimensional volumetric segmentation of target lesions was performed at the last MR examination before orthotopic liver transplantation or surgical resection. The amount of @entity1 tissue on contrast material-enhanced arterial phase MR images and the amount of diffusion-restricted @entity1 tissue on apparent diffusion coefficient ( ADC apparent diffusion coefficient ) maps were expressed as a percentage of the total @entity1 volume. Visual assessment of the extent of @entity1 @entity2 and @entity1 response according to European Association for the Study of the Liver ( EASL European Association for the Study of the Liver ) criteria was performed. Pathologic @entity1 @entity2 was quantified by using slide-by-slide segmentation. Correlation analysis was performed to evaluate the predictive values of the radiologic techniques. Results At histopathologic examination, the mean percentage of @entity1 @entity2 was 70% (range, 10%-100%). Both 3D three-dimensional quantitative techniques demonstrated a strong correlation with @entity1 @entity2 at pathologic examination (R(2) = 0.9657 and R(2) = 0.9662 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively) and a strong intermethod agreement (R(2) = 0.9585). Both methods showed a significantly lower discrepancy with pathologically measured @entity2 (residual standard error [ RSE residual standard error ] = 6.38 and 6.33 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively), when compared with non- 3D three-dimensional techniques ( RSE residual standard error = 12.18 for visual assessment). Conclusion This radiologic-pathologic correlation study demonstrates the diagnostic accuracy of 3D three-dimensional quantitative MR imaging techniques in identifying pathologically measured @entity1 @entity2 in @entity3 lesions treated with @entity4 transarterial chemoembolization .    RSNA, 2014 Online supplemental material is available for this article.

title: Radiologic-Pathologic Analysis of Contrast-enhanced and Diffusion-weighted MR Imaging in @entity0 with HCC after XXXX : Diagnostic Accuracy of 3D Quantitative Image Analysis.

answer: @entity4


abstract: Purpose To evaluate the diagnostic performance of three-dimensional ( 3D three-dimensional ) quantitative enhancement-based and diffusion-weighted volumetric magnetic resonance (MR) imaging assessment of @entity3 ( @entity3 ) lesions in determining the extent of pathologic @entity2 ( @entity4 transarterial chemoembolization ). Materials and Methods This institutional review board-approved retrospective study included 17 @entity0 with @entity3 who underwent @entity4 transarterial chemoembolization before surgery. Semiautomatic 3D three-dimensional volumetric segmentation of target lesions was performed at the last MR examination before orthotopic liver transplantation or surgical resection. The amount of @entity1 tissue on contrast material-enhanced arterial phase MR images and the amount of diffusion-restricted @entity1 tissue on apparent diffusion coefficient ( ADC apparent diffusion coefficient ) maps were expressed as a percentage of the total @entity1 volume. Visual assessment of the extent of @entity1 @entity2 and @entity1 response according to European Association for the Study of the Liver ( EASL European Association for the Study of the Liver ) criteria was performed. Pathologic @entity1 @entity2 was quantified by using slide-by-slide segmentation. Correlation analysis was performed to evaluate the predictive values of the radiologic techniques. Results At histopathologic examination, the mean percentage of @entity1 @entity2 was 70% (range, 10%-100%). Both 3D three-dimensional quantitative techniques demonstrated a strong correlation with @entity1 @entity2 at pathologic examination (R(2) = 0.9657 and R(2) = 0.9662 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively) and a strong intermethod agreement (R(2) = 0.9585). Both methods showed a significantly lower discrepancy with pathologically measured @entity2 (residual standard error [ RSE residual standard error ] = 6.38 and 6.33 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively), when compared with non- 3D three-dimensional techniques ( RSE residual standard error = 12.18 for visual assessment). Conclusion This radiologic-pathologic correlation study demonstrates the diagnostic accuracy of 3D three-dimensional quantitative MR imaging techniques in identifying pathologically measured @entity1 @entity2 in @entity3 lesions treated with @entity4 transarterial chemoembolization .    RSNA, 2014 Online supplemental material is available for this article.

title: Radiologic-Pathologic Analysis of Contrast-enhanced and Diffusion-weighted MR Imaging in XXXX with HCC after @entity4 : Diagnostic Accuracy of 3D Quantitative Image Analysis.

answer: @entity0


abstract: PURPOSE: To evaluate whether adding a contrast-enhanced fluid-attenuated inversion recovery (FLAIR) sequence to routine magnetic resonance imaging (MRI) can detect additional abnormalities in the brains of symptomatic @entity0 with mild @entity2 . MATERIALS AND METHODS: Fifty-four @entity0 with persistent symptoms following mild @entity6 were included in our retrospective study (M     F = 32     22, mean age: 59.8    16.4, age range: 26-84 years). All MRI examinations were obtained within 14 days after @entity3 (mean: 3.2    4.1 days, range: 0.2-14 days). Two neuroradiologists recorded (1) the presence of traumatic @entity1 on MR images with and without contrast-enhanced FLAIR images and (2) the pattern and location of meningeal enhancement depicted on contrast-enhanced FLAIR images. The number of additional traumatic @entity1 diagnosed with contrast-enhanced FLAIR was recorded. Correlations between meningeal enhancement and clinical findings were also evaluated. RESULTS: Traumatic @entity1 were detected on routine image sequences in 25 @entity0 . Three additional cases of @entity1 were detected with the contrast-enhanced FLAIR images. Meningeal enhancement was identified on contrast-enhanced FLAIR images in 9 cases while the other routine image sequences showed no findings of @entity2 . Overall, the additional contrast-enhanced FLAIR images revealed more extensive abnormalities than routine imaging in 37 cases (p<0.001). In multivariate logistic regression analysis, subdural @entity5 and @entity4 showed a significant association with meningeal enhancement on contrast-enhanced FLAIR images, with odds ratios 13.068 (95% confidence interval 2.037 to 83.852), and 15.487 (95% confidence interval 2.545 to 94.228), respectively. CONCLUSION: Meningeal enhancement on contrast-enhanced FLAIR images can help detect traumatic @entity1 as well as additional abnormalities not identified on routine unenhanced MRI. Therefore contrast-enhanced FLAIR MR imaging is recommended when a contrast MR study is indicated in a @entity0 with a symptomatic prior closed mild @entity3 .

title: Contrast-enhanced FLAIR (fluid-attenuated inversion recovery) for evaluating mild XXXX .

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of anterior cervical corpectomy and fusion (ACCF) and anterior cervical discectomy and fusion (ACDF) for treating two-adjacent-level @entity4 ( @entity4 ). DESIGN: A meta-analysis of the two anterior fusion methods was conducted. The electronic databases of PubMed, the Cochrane Central Register of Controlled Trials, ScienceDirect, CNKI, WANFANG DATA and CQVIP were searched. Quality assessment of the included studies was evaluated using the Cochrane Risk of Bias Tool and the Methodological Index for Non-Randomised Studies criteria. Pooled risk ratios of dichotomous outcomes and standardised mean differences (SMDs) of continuous outcomes were generated. Using the   (2) and I(2) tests, the statistical heterogeneity was assessed. Subgroup and sensitivity analyses were also performed. @entity0 : Nine eligible trials with a total of 631 @entity0 and a male-to-female ratio of 1.38:1 were included in this meta-analysis. INCLUSION CRITERIA: Randomised controlled trials (RCTs) and non-randomised controlled trials that adopted ACCF and ACDF to treat two-adjacent-level @entity4 were included. RESULTS: No significant differences were identified between the two groups regarding hospital stay, the Japanese Orthopaedic Association (JOA) score, visual analogue scale (VAS) scores for neck and arm @entity1 (ROM), fusion ROM, fusion rate, adjacent-level ossification and complications, while ACDF had significantly less @entity2 ( @entity5 =1.14, 95% CI (0.74 to 1.53)); a shorter operation time ( @entity5 =1.13, 95% CI (0.82 to 1.45)); greater cervical @entity3 , total cervical ( @entity5 =-2.95, 95% CI (-4.79 to -1.12)) and fused segment ( @entity5 =-2.24, 95% CI (-3.31 to -1.17)); higher segmental height ( @entity5 =-0.68, 95% CI (-1.03 to -0.34)) and less graft subsidence ( @entity5 =0.40, 95% CI (0.06 to 0.75)) compared to ACCF. CONCLUSIONS: The results suggested that ACDF has more advantages compared to ACCF. However, additional high-quality RCTs and a longer follow-up duration are needed.

title: Comparison of two anterior fusion methods in two-level XXXX : a meta-analysis.

answer: @entity4


abstract: OBJECTIVE: To relate neurophysiologic changes after mild/moderate @entity4 to @entity3 in a longitudinal diffusion tensor imaging investigation. METHODS: Fifty-three @entity0 were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three @entity0 were rescanned 1 year later. Thirty-three matched control subjects were recruited. At the time of scanning, @entity0 completed cognitive testing. Tract-Based Spatial Statistics was used to conduct voxel-wise analysis on diffusion changes and to explore regressions between diffusion metrics and cognitive performance. RESULTS: Acutely, increased axial diffusivity drove a fractional anisotropy (FA) increase, while decreased radial diffusivity drove a negative regression between FA and Verbal Letter Fluency across widespread white matter regions, but particularly in the ascending fibers of the corpus callosum. Raised FA is hypothesized to be caused by astrogliosis and compaction of axonal neurofilament, which would also affect cognitive functioning. Chronically, FA was decreased, suggesting @entity1 , but still regressed negatively with Verbal Letter Fluency in the anterior forceps. CONCLUSIONS: Acute mild/moderate @entity4 is characterized by increased tissue FA, which represents a clear neurobiological link between @entity3 and @entity2 after mild/moderate injury.

title: White matter correlates of @entity3 after mild XXXX .

answer: @entity4


abstract: OBJECTIVE: To relate neurophysiologic changes after mild/moderate @entity4 to @entity3 in a longitudinal diffusion tensor imaging investigation. METHODS: Fifty-three @entity0 were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three @entity0 were rescanned 1 year later. Thirty-three matched control subjects were recruited. At the time of scanning, @entity0 completed cognitive testing. Tract-Based Spatial Statistics was used to conduct voxel-wise analysis on diffusion changes and to explore regressions between diffusion metrics and cognitive performance. RESULTS: Acutely, increased axial diffusivity drove a fractional anisotropy (FA) increase, while decreased radial diffusivity drove a negative regression between FA and Verbal Letter Fluency across widespread white matter regions, but particularly in the ascending fibers of the corpus callosum. Raised FA is hypothesized to be caused by astrogliosis and compaction of axonal neurofilament, which would also affect cognitive functioning. Chronically, FA was decreased, suggesting @entity1 , but still regressed negatively with Verbal Letter Fluency in the anterior forceps. CONCLUSIONS: Acute mild/moderate @entity4 is characterized by increased tissue FA, which represents a clear neurobiological link between @entity3 and @entity2 after mild/moderate injury.

title: White matter correlates of XXXX after mild @entity4 .

answer: @entity3


abstract: BACKGROUND: Newer approaches to mammography, including digital image acquisition and computer-aided detection (CAD), and adjunct imaging (e.g., magnetic resonance imaging [MRI]) have diffused into clinical practice. The impact of these technologies on screening-related cost and outcomes remains undefined, particularly among older @entity1 . METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we constructed two cohorts of @entity1 without a history of @entity0 and followed each cohort for 2 years. We compared the use and cost of screening mammography including digital mammography and CAD, adjunct procedures including breast ultrasound, MRI, and biopsy between the period of 2001 and 2002 and the period of 2008 and 2009 using   (2) and t test. We also assessed the change in @entity0 stage and incidence rates using   (2) and Poisson regression. All statistical tests were two-sided. RESULTS: There were 137150 @entity1 (mean age = 76.0 years) in the early cohort (2001-2002) and 133097 @entity1 (mean age = 77.3 years) in the later cohort (2008-2009). The use of digital image acquisition for screening mammography increased from 2.0% in 2001 and 2002 to 29.8% in 2008 and 2009 (P < .001). CAD use increased from 3.2% to 33.1% (P < .001). Average screening-related cost per capita increased from  76 to  112 (P < .001), with annual national fee-for-service Medicare spending increasing from  666 million to  962 million. There was no statistically significant change in detection rates of early-stage @entity2 (2.45 vs 2.57 per 1000 @entity1 -years; P = .41). CONCLUSIONS: Although @entity0 screening-related costs increased substantially from 2001 through 2009 among Medicare beneficiaries, a clinically significant change in stage at diagnosis was not observed.

title: Evolution of XXXX screening in the Medicare population: clinical and economic implications.

answer: @entity0


abstract: @entity1 directly modulates the BK @entity2 channel to alter behaviors in species ranging from invertebrates to @entity0 . In the @entity5 @entity5 , mutations that eliminate the BK channel, @entity7 , convey dramatic resistance to intoxication by @entity3 . We hypothesized that certain conserved @entity4 are critical for @entity3 modulation, but not for basal channel function. To identify such residues, we screened @entity5 strains with different missense mutations in the @entity7 channel. A strain with the @entity7 missense mutation @entity8 in the RCK1 domain was highly resistant to intoxication. This mutation did not interfere with other BK channel-dependent behaviors, suggesting that the mutant channel retained normal in vivo function. Knock-in of wild-type versions of the worm or @entity0 BK channel rescued intoxication and other BK channel-dependent behaviors in a @entity6 -null mutant background. In contrast, knock-in of the worm @entity8 or equivalent @entity0 @entity9 mutant BK channel selectively rescued BK channel-dependent behaviors while conveying resistance to intoxication. Single-channel patch-clamp recordings confirmed that the @entity0 BK channel engineered with the @entity9 missense mutation was insensitive to activation by @entity3 , but otherwise had normal conductance, @entity2 selectivity, and only subtle differences in voltage dependence. Together, our behavioral and electrophysiological results demonstrate that the @entity9 mutation selectively disrupts @entity3 modulation of the BK channel. The @entity9 mutation may alter a binding site for @entity3 and/or interfere with @entity3 -induced conformational changes that are critical for behavioral responses to @entity3 .

title: Conserved single residue in the BK @entity2 channel required for activation by XXXX and intoxication in @entity5 .

answer: @entity1


abstract: @entity1 directly modulates the BK @entity2 channel to alter behaviors in species ranging from invertebrates to @entity0 . In the @entity5 @entity5 , mutations that eliminate the BK channel, @entity7 , convey dramatic resistance to intoxication by @entity3 . We hypothesized that certain conserved @entity4 are critical for @entity3 modulation, but not for basal channel function. To identify such residues, we screened @entity5 strains with different missense mutations in the @entity7 channel. A strain with the @entity7 missense mutation @entity8 in the RCK1 domain was highly resistant to intoxication. This mutation did not interfere with other BK channel-dependent behaviors, suggesting that the mutant channel retained normal in vivo function. Knock-in of wild-type versions of the worm or @entity0 BK channel rescued intoxication and other BK channel-dependent behaviors in a @entity6 -null mutant background. In contrast, knock-in of the worm @entity8 or equivalent @entity0 @entity9 mutant BK channel selectively rescued BK channel-dependent behaviors while conveying resistance to intoxication. Single-channel patch-clamp recordings confirmed that the @entity0 BK channel engineered with the @entity9 missense mutation was insensitive to activation by @entity3 , but otherwise had normal conductance, @entity2 selectivity, and only subtle differences in voltage dependence. Together, our behavioral and electrophysiological results demonstrate that the @entity9 mutation selectively disrupts @entity3 modulation of the BK channel. The @entity9 mutation may alter a binding site for @entity3 and/or interfere with @entity3 -induced conformational changes that are critical for behavioral responses to @entity3 .

title: Conserved single residue in the BK @entity2 channel required for activation by @entity1 and intoxication in XXXX .

answer: @entity5


abstract: @entity1 directly modulates the BK @entity2 channel to alter behaviors in species ranging from invertebrates to @entity0 . In the @entity5 @entity5 , mutations that eliminate the BK channel, @entity7 , convey dramatic resistance to intoxication by @entity3 . We hypothesized that certain conserved @entity4 are critical for @entity3 modulation, but not for basal channel function. To identify such residues, we screened @entity5 strains with different missense mutations in the @entity7 channel. A strain with the @entity7 missense mutation @entity8 in the RCK1 domain was highly resistant to intoxication. This mutation did not interfere with other BK channel-dependent behaviors, suggesting that the mutant channel retained normal in vivo function. Knock-in of wild-type versions of the worm or @entity0 BK channel rescued intoxication and other BK channel-dependent behaviors in a @entity6 -null mutant background. In contrast, knock-in of the worm @entity8 or equivalent @entity0 @entity9 mutant BK channel selectively rescued BK channel-dependent behaviors while conveying resistance to intoxication. Single-channel patch-clamp recordings confirmed that the @entity0 BK channel engineered with the @entity9 missense mutation was insensitive to activation by @entity3 , but otherwise had normal conductance, @entity2 selectivity, and only subtle differences in voltage dependence. Together, our behavioral and electrophysiological results demonstrate that the @entity9 mutation selectively disrupts @entity3 modulation of the BK channel. The @entity9 mutation may alter a binding site for @entity3 and/or interfere with @entity3 -induced conformational changes that are critical for behavioral responses to @entity3 .

title: Conserved single residue in the BK XXXX channel required for activation by @entity1 and intoxication in @entity5 .

answer: @entity2


abstract: UNASSIGNED: Essentials Elastic compression stocking (ECS) therapy is used to prevent @entity1 ( @entity1 ). We aimed to elicit @entity0 preferences regarding ECS therapy after @entity2 . The most valued attributes were @entity1 risk reduction and the ability to put on the ECS independently. Heterogeneous results with respect to education level stress the importance of proper counselling. SUMMARY: Background Elastic compression stocking (ECS) therapy is used for prevention of @entity1 ( @entity1 ) after @entity2 ( @entity2 ). Current evidence on its effectiveness is conflicting. Compliance, a major determinant of the effectiveness of ECS therapy, remained largely ignored in former studies. Objectives To gain insight into preferences regarding ECS therapy in @entity0 after @entity2 . @entity0 /methods A discrete choice experiment was conducted 3 months after @entity2 in @entity0 enrolled in the IDEAL @entity2 study, a randomized controlled trial comparing 2 years of ECS therapy with individually tailored duration of ECS therapy for the prevention of @entity1 . Nine unlabeled, forced-choice sets of two hypothetical types of ECS were presented to each @entity0 . Data were analyzed with multinomial logit models. Results The respondent sample consisted of 81% (300/369) of invited @entity0 . The most important determinants of preference were @entity1 risk reduction and putting on the ECS. @entity0 were willing to increase the duration of therapy by 1 year if this increases the @entity1 risk reduction with 10%. @entity0 accepted an increase in the risk of @entity1 of 29% if they were able to put on the ECS themselves. Preferences were heterogeneous with respect to education level. Conclusions Reduction of the risk of @entity1 and the ability to put on the ECS without help are the most important characteristics of ECS therapy. Physicians should pay considerable attention to @entity0 education regarding @entity1 . In addition, @entity0 should be supported in their ability to put on and take off the ECS independently. These rather simple interventions could improve compliance.

title: Eliciting @entity0 ' preferences for elastic compression stocking therapy after XXXX : potential for improving compliance.

answer: @entity2


abstract: UNASSIGNED: Essentials Elastic compression stocking (ECS) therapy is used to prevent @entity1 ( @entity1 ). We aimed to elicit @entity0 preferences regarding ECS therapy after @entity2 . The most valued attributes were @entity1 risk reduction and the ability to put on the ECS independently. Heterogeneous results with respect to education level stress the importance of proper counselling. SUMMARY: Background Elastic compression stocking (ECS) therapy is used for prevention of @entity1 ( @entity1 ) after @entity2 ( @entity2 ). Current evidence on its effectiveness is conflicting. Compliance, a major determinant of the effectiveness of ECS therapy, remained largely ignored in former studies. Objectives To gain insight into preferences regarding ECS therapy in @entity0 after @entity2 . @entity0 /methods A discrete choice experiment was conducted 3 months after @entity2 in @entity0 enrolled in the IDEAL @entity2 study, a randomized controlled trial comparing 2 years of ECS therapy with individually tailored duration of ECS therapy for the prevention of @entity1 . Nine unlabeled, forced-choice sets of two hypothetical types of ECS were presented to each @entity0 . Data were analyzed with multinomial logit models. Results The respondent sample consisted of 81% (300/369) of invited @entity0 . The most important determinants of preference were @entity1 risk reduction and putting on the ECS. @entity0 were willing to increase the duration of therapy by 1 year if this increases the @entity1 risk reduction with 10%. @entity0 accepted an increase in the risk of @entity1 of 29% if they were able to put on the ECS themselves. Preferences were heterogeneous with respect to education level. Conclusions Reduction of the risk of @entity1 and the ability to put on the ECS without help are the most important characteristics of ECS therapy. Physicians should pay considerable attention to @entity0 education regarding @entity1 . In addition, @entity0 should be supported in their ability to put on and take off the ECS independently. These rather simple interventions could improve compliance.

title: Eliciting XXXX ' preferences for elastic compression stocking therapy after @entity2 : potential for improving compliance.

answer: @entity0


abstract: BACKGROUND: Glandular @entity1 (GMs) (pancreas, breast, parotid, thyroid, or contralateral adrenal) are rare in metastatic @entity2 (mccRCC). In a multicenter study we have assessed outcome from mccRCC with or without GMs. @entity0 AND METHODS: @entity0 with mccRCC and @entity3 or non- @entity3 (NGM) at first presentation of mccRCC, treated at 9 European centers (5 French, 3 UK, and 1 Belgian centers) between January 2004 and October 2013, were retrospectively analyzed. Association between overall survival (OS) and site of @entity1 was assessed using the log-rank test for univariate analysis and the chi-square test for multivariable Cox regression. RESULTS: In all, 138 @entity0 with @entity3 mccRCC and 420 with NGM mccRCC were included; 37.2% @entity0 with @entity3 had Memorial Sloan-Kettering Cancer Center (MSKCC)-favorable risk vs. 18% NGM @entity0 ; 10.7% @entity0 with @entity3 had MSKCC-poor risk vs. 27% NGM @entity0 (P<0.0001). Median interval from @entity1 to treatment was 4.2 months (range: 0-221.3mo). Median OS was 61.5 months (51.4-81.6mo) for @entity3 and 37.4 months (31.3-42mo) for NGM (hazard ratio [HR] = 1.7; 95% CI = 1.3-2.2, P<0.001). In univariate OS analysis, age, delay between initial diagnosis and @entity1 , MSKCC, bone/lung @entity1 , and @entity3 or NGM group were significant parameters (P<0.001). In multivariate analysis, adjusted according to MSKCC risk group, NGM vs. @entity3 was a strong prognostic factor (HR = 1.4; 95% CI = 1.0-1.8, P=0.026); bone or liver @entity1 were also significant (HR = 1.3; 95% CI = 1.1-1.7, P<0.02; HR = 1.4; 95% CI = 1.1-1.7, P<0.02, respectively). Even in @entity0 without bone or liver @entity1 , @entity3 status was significant (HR = 1.8; 95% CI = 1.2-2.7, P<0.004). CONCLUSIONS: This large retrospective study shows that the presence of at least 1 @entity3 site in development of mccRCC was associated with a significantly longer OS. The presence of GMs vs. NGM disease was an independent prognostic factor for survival irrespective of the presence or absence of bone or liver @entity1 . This finding could affect daily practice in which @entity0 with mccRCC and GMs should receive more aggressive treatment with a potential for long-term survival. The causal mechanisms for this improved prognosis in @entity3 mccRCC would be evaluated in translational studies.

title: Effect of glandular @entity1 on overall survival of @entity0 with metastatic XXXX in the antiangiogenic therapy era.

answer: @entity2


abstract: BACKGROUND: Glandular @entity1 (GMs) (pancreas, breast, parotid, thyroid, or contralateral adrenal) are rare in metastatic @entity2 (mccRCC). In a multicenter study we have assessed outcome from mccRCC with or without GMs. @entity0 AND METHODS: @entity0 with mccRCC and @entity3 or non- @entity3 (NGM) at first presentation of mccRCC, treated at 9 European centers (5 French, 3 UK, and 1 Belgian centers) between January 2004 and October 2013, were retrospectively analyzed. Association between overall survival (OS) and site of @entity1 was assessed using the log-rank test for univariate analysis and the chi-square test for multivariable Cox regression. RESULTS: In all, 138 @entity0 with @entity3 mccRCC and 420 with NGM mccRCC were included; 37.2% @entity0 with @entity3 had Memorial Sloan-Kettering Cancer Center (MSKCC)-favorable risk vs. 18% NGM @entity0 ; 10.7% @entity0 with @entity3 had MSKCC-poor risk vs. 27% NGM @entity0 (P<0.0001). Median interval from @entity1 to treatment was 4.2 months (range: 0-221.3mo). Median OS was 61.5 months (51.4-81.6mo) for @entity3 and 37.4 months (31.3-42mo) for NGM (hazard ratio [HR] = 1.7; 95% CI = 1.3-2.2, P<0.001). In univariate OS analysis, age, delay between initial diagnosis and @entity1 , MSKCC, bone/lung @entity1 , and @entity3 or NGM group were significant parameters (P<0.001). In multivariate analysis, adjusted according to MSKCC risk group, NGM vs. @entity3 was a strong prognostic factor (HR = 1.4; 95% CI = 1.0-1.8, P=0.026); bone or liver @entity1 were also significant (HR = 1.3; 95% CI = 1.1-1.7, P<0.02; HR = 1.4; 95% CI = 1.1-1.7, P<0.02, respectively). Even in @entity0 without bone or liver @entity1 , @entity3 status was significant (HR = 1.8; 95% CI = 1.2-2.7, P<0.004). CONCLUSIONS: This large retrospective study shows that the presence of at least 1 @entity3 site in development of mccRCC was associated with a significantly longer OS. The presence of GMs vs. NGM disease was an independent prognostic factor for survival irrespective of the presence or absence of bone or liver @entity1 . This finding could affect daily practice in which @entity0 with mccRCC and GMs should receive more aggressive treatment with a potential for long-term survival. The causal mechanisms for this improved prognosis in @entity3 mccRCC would be evaluated in translational studies.

title: Effect of glandular XXXX on overall survival of @entity0 with metastatic @entity2 in the antiangiogenic therapy era.

answer: @entity1


abstract: BACKGROUND: Glandular @entity1 (GMs) (pancreas, breast, parotid, thyroid, or contralateral adrenal) are rare in metastatic @entity2 (mccRCC). In a multicenter study we have assessed outcome from mccRCC with or without GMs. @entity0 AND METHODS: @entity0 with mccRCC and @entity3 or non- @entity3 (NGM) at first presentation of mccRCC, treated at 9 European centers (5 French, 3 UK, and 1 Belgian centers) between January 2004 and October 2013, were retrospectively analyzed. Association between overall survival (OS) and site of @entity1 was assessed using the log-rank test for univariate analysis and the chi-square test for multivariable Cox regression. RESULTS: In all, 138 @entity0 with @entity3 mccRCC and 420 with NGM mccRCC were included; 37.2% @entity0 with @entity3 had Memorial Sloan-Kettering Cancer Center (MSKCC)-favorable risk vs. 18% NGM @entity0 ; 10.7% @entity0 with @entity3 had MSKCC-poor risk vs. 27% NGM @entity0 (P<0.0001). Median interval from @entity1 to treatment was 4.2 months (range: 0-221.3mo). Median OS was 61.5 months (51.4-81.6mo) for @entity3 and 37.4 months (31.3-42mo) for NGM (hazard ratio [HR] = 1.7; 95% CI = 1.3-2.2, P<0.001). In univariate OS analysis, age, delay between initial diagnosis and @entity1 , MSKCC, bone/lung @entity1 , and @entity3 or NGM group were significant parameters (P<0.001). In multivariate analysis, adjusted according to MSKCC risk group, NGM vs. @entity3 was a strong prognostic factor (HR = 1.4; 95% CI = 1.0-1.8, P=0.026); bone or liver @entity1 were also significant (HR = 1.3; 95% CI = 1.1-1.7, P<0.02; HR = 1.4; 95% CI = 1.1-1.7, P<0.02, respectively). Even in @entity0 without bone or liver @entity1 , @entity3 status was significant (HR = 1.8; 95% CI = 1.2-2.7, P<0.004). CONCLUSIONS: This large retrospective study shows that the presence of at least 1 @entity3 site in development of mccRCC was associated with a significantly longer OS. The presence of GMs vs. NGM disease was an independent prognostic factor for survival irrespective of the presence or absence of bone or liver @entity1 . This finding could affect daily practice in which @entity0 with mccRCC and GMs should receive more aggressive treatment with a potential for long-term survival. The causal mechanisms for this improved prognosis in @entity3 mccRCC would be evaluated in translational studies.

title: Effect of glandular @entity1 on overall survival of XXXX with metastatic @entity2 in the antiangiogenic therapy era.

answer: @entity0


abstract: To establish a series of objective parameters to predict the risk of relapse from axillary lymph node-negative (ANN) @entity0 , and evaluate the patterns of recurrence according to molecular subtypes, we collected information on 2126 consecutive @entity0 @entity1 operated between 2002 and 2006. In this case-control study, 212 @entity1 experiencing recurrence or @entity0 related @entity6 were defined as 'poor group'. Another 212 @entity1 were selected from the remaining cases with stratified sampling method to comprise the 'good group'. Significant differences were found in vascular invasion, grade and molecular subtype between the two groups. Expression of ER and PR in the 'poor group' was lower (P < 0.05). However, positive rates of Ki67, @entity9 and @entity4 in the 'poor group' were higher (P < 0.05). Multivariate analysis revealed that molecular subtype, expression of @entity4 , @entity3 grade, and vascular invasion were closely correlated with bad outcome. Analysis of the 'poor group' demonstrated that ' @entity11 positive' and 'triple negative' subtypes more commonly suffered from distant metastases and @entity6 . No @entity2 was found in @entity1 with pure invasive @entity10 , invasive @entity7 or @entity12 , whereas the diagnoses of invasive @entity5 , invasive @entity5 , invasive @entity10 mixed @entity8 , or @entity5 were correlated with distant @entity2 and @entity6 . In conclusion, molecular subtype and expression of @entity4 are useful markers for predicting prognosis of ANN @entity0 @entity1 . 'Luminal A-like' subtype has better outcome than others. Moreover, molecular subtypes have different recurrence patterns.

title: Predictors of recurrence in XXXX subtypes with negative lymph node in a Chinese population.

answer: @entity0