abstract: Subcellular localization of gene products and cell migration are both critical for pattern formation during development. The bullwinkle gene is required in @entity0 for disparate aspects of these processes. In females mutant at the bullwinkle locus, the follicle cells that synthesize the dorsal eggshell filaments do not migrate properly, creating short, broad structures. Mosaic analyses demonstrate that wild-type BULLWINKLE function is required in the germ line for these migrations. Since the mRNA for gurken, the putative ligand that signals dorsal follicle cell fate, is correctly localized in bullwinkle mutants, we conclude that our bullwinkle alleles do not affect the dorsoventral polarity of the oocyte and thus must be affecting the follicle cell migrations in some other way. In addition, the embryos that develop from bullwinkle mothers are bicaudal. A @entity2 : @entity1 fusion protein is correctly localized to the posterior pole of bullwinkle oocytes during stage 9. Thus, the microtubule structure of the oocyte and general transport along it do not appear to be disrupted prior to cytoplasmic streaming. Unlike other bicaudal mutants, oskar mRNA is localized correctly to the posterior pole of the oocyte at stage 10. By early embryogenesis, however, some oskar mRNA is mislocalized to the anterior pole. Consistent with the mislocalization of oskar mRNA, a fraction of the @entity4 protein and @entity3 mRNA are also mislocalized to the anterior pole of bullwinkle embryos. Mislocalization of @entity3 mRNA to the anterior is dependent on functional @entity4 protein. Although the mirror-image segmentation defects appear to result from the action of the posterior group genes, germ cells are not formed at the anterior pole. The bicaudal phenotype is also germ-line dependent for bullwinkle. We suspect that BULLWINKLE interacts with the cytoskeleton and extracellular matrix and is necessary for gene product localization and cell migration during oogenesis after stage 10a.

title: Mutations in the XXXX gene bullwinkle cause the formation of abnormal eggshell structures and bicaudal embryos.

answer: @entity0


abstract: 1. The transcriptional regulation of the @entity2 brain L-type @entity3 channel alpha 1D subunit (RB alpha 1D) gene was investigated using @entity1 @entity0 cells. 2. Differentiation of @entity1 cells in the presence of @entity6 or @entity5 resulted in the appearance of mRNA encoding the RB alpha 1D subunit detected using Northern blot analysis. 3. A @entity2 genomic DNA library was screened, and a 15.2-kb clone was isolated and partially sequenced which included part of the 5' upstream sequence through the initial part of intron 2 of the RB alpha 1D gene. 4. Deletion analysis, using a CAT reporter gene and transfected @entity1 cells, revealed that the 1.2-kb 5'-upstream sequence from the RB alpha 1D gene contains cis-acting positive and negative regulatory elements. A deletion of the 3' end of exon 1 also suggested the presence of regulatory elements in the first exon. 5. DNase footprinting of exon 1 of the RB alpha 1D gene revealed two regions protected from digestion by specific protein binding, and the second region included an (ATG)7 trinucleotide repeat sequence. Electrophoretic mobility shift assays confirmed nuclear protein(s) binding to the (ATG)7 sequence. 6. The (ATG)7 sequence functions as a enhancer when linked to a @entity4 kinase promoter and a CAT reporter gene. 7. These results provide the initial description of the transcriptional regulation of the RB alpha 1D gene and identify a novel enhancer that consists of an (ATG)7 trinucleotide repeat sequence.

title: Transcriptional regulation of the neuronal L-type XXXX channel alpha 1D subunit gene.

answer: @entity3


abstract: OBJECTIVE: Accuracy of continuous @entity2 monitoring (CGM) devices in @entity6 has been a widely reported shortcoming of this technology. We report the accuracy in @entity6 of a new version of the Dexcom (San Diego, CA) G4 @entity3 CGM system (software 505) and present results regarding the optimum setting of CGM hypoglycemic alerts. MATERIALS AND METHODS: CGM values were compared with YSI analyzer (YSI Life Sciences, Yellow Springs, @entity4 ) measurements every 15   min. We reviewed the accuracy of the CGM system in the hypoglycemic range using standard metrics. We analyzed the time required for the CGM system to detect biochemical @entity6 (70   mg/dL) compared with the YSI with alert settings at 70   mg/dL and 80   mg/dL. We also analyzed the time between the YSI value crossing 55   mg/dL, defined as the threshold for @entity1 due to @entity6 , and when the CGM system alerted for @entity6 . RESULTS: The mean absolute difference for a @entity2 level of less than 70   mg/dL was 6   mg/dL. Ninety-six percent of CGM values were within 20   mg/dL of the YSI values between 40 and 80   mg/dL. When the CGM hypoglycemic alert was set at 80   mg/dL, the device provided an alert for biochemical @entity6 within 10   min in 95% of instances and at least a 10-min advance warning before the @entity1 threshold in 91% of instances in the study. CONCLUSIONS: Use of an 80   mg/dL threshold setting for hypoglycemic alerts on the G4 @entity3 (software 505) may provide @entity0 with timely warning of @entity6 before the onset of @entity1 , enabling them to treat themselves for @entity6 with fast-acting @entity5 and prevent neuroglycopenia associated with very low @entity2 levels.

title: Hypoglycemic Accuracy and Improved Low XXXX Alerts of the Latest Dexcom G4 @entity3 Continuous @entity2 Monitoring System.

answer: @entity2


abstract: OBJECTIVE: Accuracy of continuous @entity2 monitoring (CGM) devices in @entity6 has been a widely reported shortcoming of this technology. We report the accuracy in @entity6 of a new version of the Dexcom (San Diego, CA) G4 @entity3 CGM system (software 505) and present results regarding the optimum setting of CGM hypoglycemic alerts. MATERIALS AND METHODS: CGM values were compared with YSI analyzer (YSI Life Sciences, Yellow Springs, @entity4 ) measurements every 15   min. We reviewed the accuracy of the CGM system in the hypoglycemic range using standard metrics. We analyzed the time required for the CGM system to detect biochemical @entity6 (70   mg/dL) compared with the YSI with alert settings at 70   mg/dL and 80   mg/dL. We also analyzed the time between the YSI value crossing 55   mg/dL, defined as the threshold for @entity1 due to @entity6 , and when the CGM system alerted for @entity6 . RESULTS: The mean absolute difference for a @entity2 level of less than 70   mg/dL was 6   mg/dL. Ninety-six percent of CGM values were within 20   mg/dL of the YSI values between 40 and 80   mg/dL. When the CGM hypoglycemic alert was set at 80   mg/dL, the device provided an alert for biochemical @entity6 within 10   min in 95% of instances and at least a 10-min advance warning before the @entity1 threshold in 91% of instances in the study. CONCLUSIONS: Use of an 80   mg/dL threshold setting for hypoglycemic alerts on the G4 @entity3 (software 505) may provide @entity0 with timely warning of @entity6 before the onset of @entity1 , enabling them to treat themselves for @entity6 with fast-acting @entity5 and prevent neuroglycopenia associated with very low @entity2 levels.

title: Hypoglycemic Accuracy and Improved Low @entity2 Alerts of the Latest Dexcom G4 @entity3 Continuous XXXX Monitoring System.

answer: @entity2


abstract: OBJECTIVE: Accuracy of continuous @entity2 monitoring (CGM) devices in @entity6 has been a widely reported shortcoming of this technology. We report the accuracy in @entity6 of a new version of the Dexcom (San Diego, CA) G4 @entity3 CGM system (software 505) and present results regarding the optimum setting of CGM hypoglycemic alerts. MATERIALS AND METHODS: CGM values were compared with YSI analyzer (YSI Life Sciences, Yellow Springs, @entity4 ) measurements every 15   min. We reviewed the accuracy of the CGM system in the hypoglycemic range using standard metrics. We analyzed the time required for the CGM system to detect biochemical @entity6 (70   mg/dL) compared with the YSI with alert settings at 70   mg/dL and 80   mg/dL. We also analyzed the time between the YSI value crossing 55   mg/dL, defined as the threshold for @entity1 due to @entity6 , and when the CGM system alerted for @entity6 . RESULTS: The mean absolute difference for a @entity2 level of less than 70   mg/dL was 6   mg/dL. Ninety-six percent of CGM values were within 20   mg/dL of the YSI values between 40 and 80   mg/dL. When the CGM hypoglycemic alert was set at 80   mg/dL, the device provided an alert for biochemical @entity6 within 10   min in 95% of instances and at least a 10-min advance warning before the @entity1 threshold in 91% of instances in the study. CONCLUSIONS: Use of an 80   mg/dL threshold setting for hypoglycemic alerts on the G4 @entity3 (software 505) may provide @entity0 with timely warning of @entity6 before the onset of @entity1 , enabling them to treat themselves for @entity6 with fast-acting @entity5 and prevent neuroglycopenia associated with very low @entity2 levels.

title: Hypoglycemic Accuracy and Improved Low @entity2 Alerts of the Latest Dexcom G4 XXXX Continuous @entity2 Monitoring System.

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) of the common carotid artery (CCA), measured with external vascular ultrasound, has been widely used in clinical trials as a surrogate marker for @entity3 . Despite this, the degree of correlation between carotid @entity2 and the extent and severity of @entity3 ( @entity3 ) is not known. METHODS AND RESULTS: Common carotid @entity2 was measured by ultrasound in 350 consecutive subjects of age 60 +/- 10 years (range, 30 to 85 years) on the day of coronary angiography. Carotid mean @entity2 was 0.83 +/- 0.20 mm (range, 0.43 to 1.80 mm), and maximum @entity2 was 1.04 +/- 0.27 mm (range, 0.49 to 2.19 mm). Coronary angiograms were analyzed by independent observers for disease severity (number of vessels with > or = 70% stenosis), extent score, and a modified Gensini score. Mean carotid @entity2 was weakly but significantly correlated with @entity3 severity (r = .26), extent (r = .23), and modified Gensini score (r = .29, P < .0001 for all correlations). Carotid @entity2 was not clinically useful, however, because it was not specific or sensitive enough to identify @entity0 with or without significant @entity3 . Increasing age, male sex, and presence of @entity1 were all associated with a significantly (P < .01) higher @entity3 score than the average for any level of carotid @entity2 , suggesting differential effects of these traditional risk factors on the coronary and common carotid arteries. CONCLUSIONS: Although carotid @entity2 is significantly correlated with extent and severity of @entity3 , the relationship is weak. This relatively poor correlation (r2 < .10) should be considered in the interpretation of clinical trials that use carotid @entity2 as a surrogate end point for @entity3 .

title: Carotid intima-media thickness is only weakly correlated with the extent and severity of XXXX .

answer: @entity3


abstract: Epidemiological evidence suggests that sleep duration and poor sleep are associated with mortality, as well as with a wide range of negative health outcomes. However, few studies have examined the association between sleep and self-rated health, particularly through the combination of sleep complaints. The objective of this study was to examine whether self-rated health is associated with sleep complaints, considering the combination of sleep duration, @entity1 , and sleep sufficiency. This cross-sectional study was performed in the 18 largest public hospitals in the city of Rio de Janeiro, Brazil. A total of 2518 female nurses answered a self-filled multidimensional questionnaire. The adjusted odds ratios and 95% confidence intervals (CIs) estimated the chance of poor self-rated health in the presence of different combinations of sleep duration and quality. Compared with @entity0 who reported adequate sleep duration with no @entity2 (reference group), the odds ratios (95% CI) for poor self-rated health were 1.79 (1.27-2.24) for those who reported only insufficient sleep, 1.85 (0.94-3.66) for only a @entity2 , and 3.12 (1.94-5.01) for only @entity1 . Compared with those who expressed all three complaints ( @entity2 , @entity1 , and insufficient sleep), the odds ratio for poor self-rated health was 4.49 (3.25-6.22). Differences in the magnitude of the associations were observed, depending on the combination of sleep complaints. Because self-rated health is a consistent predictor of morbidity, these results reinforce the increasing awareness of the role of sleep in health and disease. Our findings contribute to the recognition of sleep as a public health matter that deserves to be better understood and addressed by policymakers.

title: Associations of a Short Sleep Duration, Insufficient Sleep, and XXXX with Self-Rated Health among Nurses.

answer: @entity1


abstract: OBJECTIVE: @entity5 ( @entity5 ) carries a high mortality rate, even with prompt transfer to a medical center. An artificial neural network (ANN) is a computational model that improves predictive ability through pattern recognition while continually adapting to new input data. The goal of this study was to effectively use ANN modeling to provide vascular surgeons a discriminant adjunct to assess the likelihood of in-hospital mortality on a pending @entity5 admission using easily obtainable @entity0 information from the field. METHODS: Of 332 total @entity0 from a single institution from 1998 to 2013 who had attempted @entity5 repair, 125 were reviewed for preoperative factors associated with in-hospital mortality; 108 @entity0 received an open operation, and 17 @entity0 received endovascular repair. Five variables were found significant on multivariate analysis (P  < .05), and four of these five (preoperative shock, @entity3 , @entity4 , and age) were modeled by multiple logistic regression and an ANN. These predictive models were compared against the Glasgow @entity2 Score. All models were assessed by generation of receiver operating characteristic curves and actual vs predicted outcomes plots, with area under the curve and Pearson r(2) value as the primary measures of discriminant ability. RESULTS: Of the 125 @entity0 , 53 (42%) did not survive to discharge. Five preoperative factors were significant (P  < .05) independent predictors of in-hospital mortality in multivariate analysis: advanced age, @entity1 , @entity3 , @entity4 , and shock, although @entity1 was excluded from the models. The sequential accumulation of zero to four of these risk factors progressively increased overall mortality rate, from 11% to 16% to 44% to 76% to 89% (age  >=   70  years considered a risk factor). Algorithms derived from multiple logistic regression, ANN, and Glasgow @entity2 Score models generated area under the curve values of 0.85     0.04, 0.88     0.04 (training set), and 0.77      0.06 and Pearson r(2) values of .36, .52 and .17, respectively. The ANN model represented the most discriminant of the three. CONCLUSIONS: An ANN-based predictive model may represent a simple, useful, and highly discriminant adjunct to the vascular surgeon in accurately identifying those @entity0 who may carry a high mortality risk from attempted repair of @entity5 , using only easily definable preoperative variables. Although still requiring external validation, our model is available for demonstration at https://redcap.vanderbilt.edu/surveys/?s=NN97NM7DTK.

title: Prediction of in-hospital mortality after XXXX repair using an artificial neural network.

answer: @entity5


abstract: @entity6 ( @entity6 ) represent 23%-34% of @entity2 primary @entity3 . @entity5 account for 2%-6% of @entity6 but myxoid variants are rarely reported and information on their behaviour is fragmentary. An 8-year-old male crossbreed (case 1), a 12-year-old female French bulldog (case 2), and an 11-year-old crossbreed (case 3) underwent splenectomy after the detection of a splenic nodule. Histology, histochemistry, immunohistochemistry, and @entity4 ( @entity4 ) were performed. Bundles of spindle-to-polygonal cells containing occasional cytoplasmic oil-red-O positive vacuoles embedded in an Alcian blue-positive extracellular matrix were observed. Aggregates of round cells were detected in cases 1 and 3. All @entity1 were vimentin positive and actin, @entity8 , @entity7 , and S100 negative. The @entity4 evidenced different maturational stages of adipose cells (lipoblasts, intermediate, and undifferentiated). All the cases developed hepatic @entity0 and were euthanized. Disease free interval was 2 months in cases 1 and 3, and 21 months in case 2. The presence of a neoplastic embolus in case 1 and areas of round cell differentiation in cases 1 and 3 represented the sole prognostic indices.

title: Pathological characterization of primary splenic myxoid liposarcomas in three XXXX .

answer: @entity2


abstract: PURPOSE: To compare the occurrence rate of @entity2 and bradycardic events (HBEs) during arthroscopic rotator cuff repair performed with interscalene brachial plexus block anesthesia in the sitting position in 2 groups of @entity0 who underwent the procedure with @entity4 or @entity5 added to the irrigation fluid. The secondary objective was to evaluate the efficacy of @entity4 in comparison with @entity5 in controlling @entity3 and maintaining adequate visualization of the arthroscopic field of view during the procedure. We hypothesized that @entity4 added to the irrigation fluid during shoulder arthroscopy in the sitting position would reduce the occurrence of HBEs, allowing optimal @entity3 control. METHODS: One hundred twenty @entity0 underwent an arthroscopic rotator cuff repair performed under peripheral anesthesia and in the beach-chair position. @entity0 were randomly divided into 2 groups of 60 cases each: @entity4 (0.66 mg/L) and @entity5 (0.33 mg/L) were added to irrigation bags in group N and group E, respectively. The primary outcome was the occurrence rate of HBEs during surgery. The secondary outcomes were timing of onset of HBEs, accompanying symptoms, and @entity3 that @entity1 . The clarity of the visual field was rated postoperatively by the surgeon using a visual analog scale. Comparison between groups for all baseline variables and outcome measurements was performed with the   (2) or Fisher exact test, as appropriate, for categorical variables and the Student t test or Mann-Whitney U test, as appropriate, for continuous variables. Significance was set at P < .05. RESULTS: One @entity0 was excluded from group E because of block failure; therefore 119 @entity0 were finally included in the study. Comparison between groups showed no significant differences in baseline characteristics. The occurrence rate of HBEs was significantly greater in group E (n  = 15) than in group N (n  = 5) (P  = .02). No differences between groups were found in the average time of onset of HBEs, accompanying symptoms, and clarity of the visual field. CONCLUSIONS: Continuous administration of @entity4 , 0.66 mg/L, diluted in irrigation fluid during arthroscopic rotator cuff repair with the @entity0 in the beach-chair position reduces the incidence of HBEs and is as effective as @entity5 in controlling @entity3 and maintaining the visual clarity of the surgical field. LEVEL OF EVIDENCE: Level I, randomized clinical study.

title: The effect of XXXX versus @entity5 in irrigation fluid on the incidence of @entity2 /bradycardic events during arthroscopic rotator cuff repair with interscalene block in the sitting position.

answer: @entity4


abstract: PURPOSE: To compare the occurrence rate of @entity2 and bradycardic events (HBEs) during arthroscopic rotator cuff repair performed with interscalene brachial plexus block anesthesia in the sitting position in 2 groups of @entity0 who underwent the procedure with @entity4 or @entity5 added to the irrigation fluid. The secondary objective was to evaluate the efficacy of @entity4 in comparison with @entity5 in controlling @entity3 and maintaining adequate visualization of the arthroscopic field of view during the procedure. We hypothesized that @entity4 added to the irrigation fluid during shoulder arthroscopy in the sitting position would reduce the occurrence of HBEs, allowing optimal @entity3 control. METHODS: One hundred twenty @entity0 underwent an arthroscopic rotator cuff repair performed under peripheral anesthesia and in the beach-chair position. @entity0 were randomly divided into 2 groups of 60 cases each: @entity4 (0.66 mg/L) and @entity5 (0.33 mg/L) were added to irrigation bags in group N and group E, respectively. The primary outcome was the occurrence rate of HBEs during surgery. The secondary outcomes were timing of onset of HBEs, accompanying symptoms, and @entity3 that @entity1 . The clarity of the visual field was rated postoperatively by the surgeon using a visual analog scale. Comparison between groups for all baseline variables and outcome measurements was performed with the   (2) or Fisher exact test, as appropriate, for categorical variables and the Student t test or Mann-Whitney U test, as appropriate, for continuous variables. Significance was set at P < .05. RESULTS: One @entity0 was excluded from group E because of block failure; therefore 119 @entity0 were finally included in the study. Comparison between groups showed no significant differences in baseline characteristics. The occurrence rate of HBEs was significantly greater in group E (n  = 15) than in group N (n  = 5) (P  = .02). No differences between groups were found in the average time of onset of HBEs, accompanying symptoms, and clarity of the visual field. CONCLUSIONS: Continuous administration of @entity4 , 0.66 mg/L, diluted in irrigation fluid during arthroscopic rotator cuff repair with the @entity0 in the beach-chair position reduces the incidence of HBEs and is as effective as @entity5 in controlling @entity3 and maintaining the visual clarity of the surgical field. LEVEL OF EVIDENCE: Level I, randomized clinical study.

title: The effect of @entity4 versus @entity5 in irrigation fluid on the incidence of XXXX /bradycardic events during arthroscopic rotator cuff repair with interscalene block in the sitting position.

answer: @entity2


abstract: PURPOSE: To compare the occurrence rate of @entity2 and bradycardic events (HBEs) during arthroscopic rotator cuff repair performed with interscalene brachial plexus block anesthesia in the sitting position in 2 groups of @entity0 who underwent the procedure with @entity4 or @entity5 added to the irrigation fluid. The secondary objective was to evaluate the efficacy of @entity4 in comparison with @entity5 in controlling @entity3 and maintaining adequate visualization of the arthroscopic field of view during the procedure. We hypothesized that @entity4 added to the irrigation fluid during shoulder arthroscopy in the sitting position would reduce the occurrence of HBEs, allowing optimal @entity3 control. METHODS: One hundred twenty @entity0 underwent an arthroscopic rotator cuff repair performed under peripheral anesthesia and in the beach-chair position. @entity0 were randomly divided into 2 groups of 60 cases each: @entity4 (0.66 mg/L) and @entity5 (0.33 mg/L) were added to irrigation bags in group N and group E, respectively. The primary outcome was the occurrence rate of HBEs during surgery. The secondary outcomes were timing of onset of HBEs, accompanying symptoms, and @entity3 that @entity1 . The clarity of the visual field was rated postoperatively by the surgeon using a visual analog scale. Comparison between groups for all baseline variables and outcome measurements was performed with the   (2) or Fisher exact test, as appropriate, for categorical variables and the Student t test or Mann-Whitney U test, as appropriate, for continuous variables. Significance was set at P < .05. RESULTS: One @entity0 was excluded from group E because of block failure; therefore 119 @entity0 were finally included in the study. Comparison between groups showed no significant differences in baseline characteristics. The occurrence rate of HBEs was significantly greater in group E (n  = 15) than in group N (n  = 5) (P  = .02). No differences between groups were found in the average time of onset of HBEs, accompanying symptoms, and clarity of the visual field. CONCLUSIONS: Continuous administration of @entity4 , 0.66 mg/L, diluted in irrigation fluid during arthroscopic rotator cuff repair with the @entity0 in the beach-chair position reduces the incidence of HBEs and is as effective as @entity5 in controlling @entity3 and maintaining the visual clarity of the surgical field. LEVEL OF EVIDENCE: Level I, randomized clinical study.

title: The effect of @entity4 versus XXXX in irrigation fluid on the incidence of @entity2 /bradycardic events during arthroscopic rotator cuff repair with interscalene block in the sitting position.

answer: @entity5


abstract: AIMS AND BACKGROUND: @entity4 is a potent and safe agent that can be used after @entity7 and @entity6 treatment in @entity1 with @entity0 ( @entity0 ). The purpose of this study was to investigate the efficacy and safety of @entity4 monotherapy as a first-line treatment in @entity1 epidermal receptor 2 ( @entity5 )-negative @entity1 with @entity0 . METHODS AND STUDY DESIGN: In this single-center trial, a total of 109 @entity5 -negative @entity1 with @entity0 who received @entity4 monotherapy as first-line treatment between 2003 and 2014 were retrospectively analyzed. Kaplan-Meier survival analysis was carried out for progression-free survival (PFS) and for overall survival (OS). Two-sided p values of <0.05 were considered statistically significant. RESULTS: Median PFS was 7.0    0.67 (confidence interval (CI) 5.6-8.3) months and median OS was 30    4.1 (CI 21.8-38.1) months. First-line @entity4 treatment for @entity5 -negative @entity0 was more effective in the @entity3 receptor (ER)-positive @entity1 population compared to the ER-negative group (median PFS 9 vs 4 months (p = 0.002), median OS 33 vs 21 months (p = 0.01)). Indeed, the overall response rate in the ER-negative group was 16%, while this was calculated as 38% for ER-positive cases. While most of our @entity1 population was treated with a higher dose (1250 mg/m2), the observed grade 3-4 @entity2 were lower compared to some previously reported phase II and phase III @entity4 studies. CONCLUSIONS: @entity4 monotherapy is an effective and safe regimen for ER-positive, @entity5 -negative @entity1 with @entity0 . Its low @entity2 profile compared to other intravenous cytotoxic agents and the ease of its oral administration make this agent a preferable option for both physicians and @entity1 .

title: Efficacy of @entity4 monotherapy as the first-line treatment of metastatic XXXX -negative @entity0 .

answer: @entity5


abstract: AIMS AND BACKGROUND: @entity4 is a potent and safe agent that can be used after @entity7 and @entity6 treatment in @entity1 with @entity0 ( @entity0 ). The purpose of this study was to investigate the efficacy and safety of @entity4 monotherapy as a first-line treatment in @entity1 epidermal receptor 2 ( @entity5 )-negative @entity1 with @entity0 . METHODS AND STUDY DESIGN: In this single-center trial, a total of 109 @entity5 -negative @entity1 with @entity0 who received @entity4 monotherapy as first-line treatment between 2003 and 2014 were retrospectively analyzed. Kaplan-Meier survival analysis was carried out for progression-free survival (PFS) and for overall survival (OS). Two-sided p values of <0.05 were considered statistically significant. RESULTS: Median PFS was 7.0    0.67 (confidence interval (CI) 5.6-8.3) months and median OS was 30    4.1 (CI 21.8-38.1) months. First-line @entity4 treatment for @entity5 -negative @entity0 was more effective in the @entity3 receptor (ER)-positive @entity1 population compared to the ER-negative group (median PFS 9 vs 4 months (p = 0.002), median OS 33 vs 21 months (p = 0.01)). Indeed, the overall response rate in the ER-negative group was 16%, while this was calculated as 38% for ER-positive cases. While most of our @entity1 population was treated with a higher dose (1250 mg/m2), the observed grade 3-4 @entity2 were lower compared to some previously reported phase II and phase III @entity4 studies. CONCLUSIONS: @entity4 monotherapy is an effective and safe regimen for ER-positive, @entity5 -negative @entity1 with @entity0 . Its low @entity2 profile compared to other intravenous cytotoxic agents and the ease of its oral administration make this agent a preferable option for both physicians and @entity1 .

title: Efficacy of @entity4 monotherapy as the first-line treatment of metastatic @entity5 -negative XXXX .

answer: @entity0


abstract: AIMS AND BACKGROUND: @entity4 is a potent and safe agent that can be used after @entity7 and @entity6 treatment in @entity1 with @entity0 ( @entity0 ). The purpose of this study was to investigate the efficacy and safety of @entity4 monotherapy as a first-line treatment in @entity1 epidermal receptor 2 ( @entity5 )-negative @entity1 with @entity0 . METHODS AND STUDY DESIGN: In this single-center trial, a total of 109 @entity5 -negative @entity1 with @entity0 who received @entity4 monotherapy as first-line treatment between 2003 and 2014 were retrospectively analyzed. Kaplan-Meier survival analysis was carried out for progression-free survival (PFS) and for overall survival (OS). Two-sided p values of <0.05 were considered statistically significant. RESULTS: Median PFS was 7.0    0.67 (confidence interval (CI) 5.6-8.3) months and median OS was 30    4.1 (CI 21.8-38.1) months. First-line @entity4 treatment for @entity5 -negative @entity0 was more effective in the @entity3 receptor (ER)-positive @entity1 population compared to the ER-negative group (median PFS 9 vs 4 months (p = 0.002), median OS 33 vs 21 months (p = 0.01)). Indeed, the overall response rate in the ER-negative group was 16%, while this was calculated as 38% for ER-positive cases. While most of our @entity1 population was treated with a higher dose (1250 mg/m2), the observed grade 3-4 @entity2 were lower compared to some previously reported phase II and phase III @entity4 studies. CONCLUSIONS: @entity4 monotherapy is an effective and safe regimen for ER-positive, @entity5 -negative @entity1 with @entity0 . Its low @entity2 profile compared to other intravenous cytotoxic agents and the ease of its oral administration make this agent a preferable option for both physicians and @entity1 .

title: Efficacy of XXXX monotherapy as the first-line treatment of metastatic @entity5 -negative @entity0 .

answer: @entity4


abstract: BACKGROUND: @entity2 ( @entity2 ), which increases knee loading, muscle co-contraction, and @entity1 , is a mechanical disease that requires biomechanical exploration to reduce @entity1 in the knee. Therefore, this article aims to investigate the effectiveness of an exercise programme on the aforementioned outcomes in @entity0 with medial knee @entity2 . METHODS: Cohort pilot study design. A total of 19 @entity0 with knee @entity2 attended a six-week group exercise programme integrated with self-management education. The following outcomes were assessed before and after the exercise programme: external knee adduction moment (EKAM), knee adduction angular impulse (KAAI), knee antagonist muscle co-contraction, and @entity1 subscale of the @entity3 and @entity2 outcome score (KOOS). RESULTS: Of the 19 @entity0 , 14 completed the study. The EKAM and KAAI did not show statistical significance post-exercise intervention (p=0.21-0.7 and 0.56, respectively). Muscle co-contraction between vastus lateralis and biceps femoris muscles decreased in early-stance (64.78 (44.35) compared with 38.10 (23.10), p=0.01) and mid-stance (27.62 (32.12) compared with 14.94 (17.40), p=0.04). A corresponding significant @entity1 reduction was observed (p=0.00) with a median (range) of 51.50 (47.00 to 62.50) at week 6 compared with 34.50 (29.25 to 41.25) at baseline. CONCLUSION: This is the first known study to explore the effect of an exercise programme on knee loading and muscle co-contraction in @entity0 with @entity2 . Although the value of EKAM did not change, the findings suggest that the reduction in vastus lateralis and biceps femoris co-contraction might be the mechanism behind the reduction of @entity1 .

title: The effectiveness of an exercise programme on knee loading, muscle co-contraction, and XXXX in @entity0 with medial knee osteoarthritis: A pilot study.

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ), which increases knee loading, muscle co-contraction, and @entity1 , is a mechanical disease that requires biomechanical exploration to reduce @entity1 in the knee. Therefore, this article aims to investigate the effectiveness of an exercise programme on the aforementioned outcomes in @entity0 with medial knee @entity2 . METHODS: Cohort pilot study design. A total of 19 @entity0 with knee @entity2 attended a six-week group exercise programme integrated with self-management education. The following outcomes were assessed before and after the exercise programme: external knee adduction moment (EKAM), knee adduction angular impulse (KAAI), knee antagonist muscle co-contraction, and @entity1 subscale of the @entity3 and @entity2 outcome score (KOOS). RESULTS: Of the 19 @entity0 , 14 completed the study. The EKAM and KAAI did not show statistical significance post-exercise intervention (p=0.21-0.7 and 0.56, respectively). Muscle co-contraction between vastus lateralis and biceps femoris muscles decreased in early-stance (64.78 (44.35) compared with 38.10 (23.10), p=0.01) and mid-stance (27.62 (32.12) compared with 14.94 (17.40), p=0.04). A corresponding significant @entity1 reduction was observed (p=0.00) with a median (range) of 51.50 (47.00 to 62.50) at week 6 compared with 34.50 (29.25 to 41.25) at baseline. CONCLUSION: This is the first known study to explore the effect of an exercise programme on knee loading and muscle co-contraction in @entity0 with @entity2 . Although the value of EKAM did not change, the findings suggest that the reduction in vastus lateralis and biceps femoris co-contraction might be the mechanism behind the reduction of @entity1 .

title: The effectiveness of an exercise programme on knee loading, muscle co-contraction, and @entity1 in XXXX with medial knee osteoarthritis: A pilot study.

answer: @entity0


abstract: The objective of this study was to determine the utility of the @entity2 monocytic @entity3 cell line as a model for analyzing molecular mechanisms involved in enhancement of @entity0 -induced @entity4 dioxygenase ( @entity5 ) activity by interleukin-1 ( @entity1 ). Following treatment of @entity2 cells with combinations of @entity0 and @entity1 , @entity5 activity and @entity5 mRNA were quantified by HPLC and radioanalytic imaging of RT-PCR products, respectively. @entity1 increased the amount of @entity5 activity and the expression of @entity5 mRNA in IFN-treated cells; @entity1 alone had no effect on untreated @entity2 cells. Because @entity5 gene regulation might differ between immature @entity2 cells and mature macrophages, experiments were repeated using primary macrophage cultures. @entity0 induced @entity5 activity, and @entity5 mRNA was expressed in a dose-dependent manner. In the presence of @entity1 , 10 times less IFN was required to obtain the same amount of @entity5 mRNA and @entity5 activity. Furthermore, @entity1 alone increased @entity5 mRNA expression. It appears that unlike what was observed in @entity2 cells, @entity1 transcriptionally activates the @entity5 gene in primary macrophages. However, increases in @entity5 activity were not observed following treatment with @entity1 alone. Although the @entity2 cell may be used to model cytokine potentiation of IFN-induced @entity5 activity, some differences in regulation between @entity2 cells and primary macrophage cultures may exist.

title: Interleukin-1 enhances XXXX 2,3-dioxygenase activity by increasing specific mRNA expression in human mononuclear phagocytes.

answer: @entity4


abstract: A randomized double-blind parallel study with 20 healthy volunteers was performed to research the effect of a preservative in a decongestant nasal spray on the development of @entity1 . Ten subjects received @entity3 nasal spray with @entity2 and the others used @entity3 nasal spray without the preservative three times daily for 30 days. Before starting the course of treatment and after its conclusion, recordings of the mucosal surface positions were made with rhinostereometry followed by @entity0 challenge tests. Symptoms of nasal stuffiness were estimated on visual analogue scales (0-100) in the morning and the evening just before using the nasal spray. After 30 days, rebound swelling and nasal stuffiness were found in both groups. In the group receiving @entity3 nasal spray with @entity2 the mean rebound swelling was 1.1 mm and the estimated mean evening symptom score for nasal stuffiness was 43. In the group without @entity2 the corresponding variables were significantly less marked, with a mean rebound swelling of 0.5 mm (P < 0.05) and a mean evening symptom score of 25 (P < 0.05). The increase in @entity0 sensitivity in both groups was interpreted as a sign of nasal hyperreactivity. A new type of nasal spray bottle was used that has been shown to prevent bacterial contamination. In conclusion, the long-term use of @entity2 in @entity3 nasal spray accentuates the severity of @entity1 in healthy volunteers.

title: @entity2 in a decongestant nasal spray aggravates XXXX in healthy volunteers.

answer: @entity1


abstract: A randomized double-blind parallel study with 20 healthy volunteers was performed to research the effect of a preservative in a decongestant nasal spray on the development of @entity1 . Ten subjects received @entity3 nasal spray with @entity2 and the others used @entity3 nasal spray without the preservative three times daily for 30 days. Before starting the course of treatment and after its conclusion, recordings of the mucosal surface positions were made with rhinostereometry followed by @entity0 challenge tests. Symptoms of nasal stuffiness were estimated on visual analogue scales (0-100) in the morning and the evening just before using the nasal spray. After 30 days, rebound swelling and nasal stuffiness were found in both groups. In the group receiving @entity3 nasal spray with @entity2 the mean rebound swelling was 1.1 mm and the estimated mean evening symptom score for nasal stuffiness was 43. In the group without @entity2 the corresponding variables were significantly less marked, with a mean rebound swelling of 0.5 mm (P < 0.05) and a mean evening symptom score of 25 (P < 0.05). The increase in @entity0 sensitivity in both groups was interpreted as a sign of nasal hyperreactivity. A new type of nasal spray bottle was used that has been shown to prevent bacterial contamination. In conclusion, the long-term use of @entity2 in @entity3 nasal spray accentuates the severity of @entity1 in healthy volunteers.

title: XXXX in a decongestant nasal spray aggravates @entity1 in healthy volunteers.

answer: @entity2


abstract: Kampou medicine is a traditional Japanese therapeutic system which originated in China and was used to treat @entity1 for hundreds of years until it was superseded by Western medicine. In recent years, there has been a resurgence of interest in Kampou medicine among many physicians. Unfortunately, however, little evaluation has been performed using objective scientific methods until now, and the pharmacodynamics of Kampou medicine are still unclear. Generally speaking, Kampou medicine has been shown to have fewer side-effects than Western medicine based on the experience gained from its long usage. We first selected 16 Kampou extracts for screening as possible @entity4 stone prophylactic agents in vitro. This resulted in the selection of two kinds of Kampou extracts, Takusya and Kagosou, as potential Kampou extracts for stone prophylaxis. Next, these two Kampou extracts were tested in vivo for their effects on stone formation in an animal model. Takusya showed significant stone prophylaxis, while Kagosou did not. Lastly, Chorei-to, which contains Takusya and has been approved for prescription as a Kampou medicine for @entity2 @entity0 in Japan, was examined in vivo at two different concentrations. As a result, a low dose of Chorei-to which corresponded to the @entity0 daily dose per unit of body weight exhibited apparent stone prophylaxis, despite the disadvantage of decreasing @entity3 excretion. In contrast, high doses of Chorei-to did not exhibit stone prophylaxis in vivo.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The inhibitory effect of kampou extracts on in vitro XXXX crystallization and in vivo stone formation in an animal model.

answer: @entity4


abstract: BACKGROUND: Dislocation of the shoulder is one of our earliest frequent injuries. Many procedures have been evaluated for treatment of the condition since the mid 1960s. The modified Bristow procedure was initially described in 1970 by May. Technically easy, the procedure is very effective in prevention of redislocation, and has gained popularity over two decades of use. METHODS: A retrospective study was done of 32 @entity0 with recurrent @entity3 , who had received modified Bristow procedure during the years 1987 through 1991 in this Hospital. Average followup period was 26 months. RESULTS: At postoperative evaluation, average loss of external rotation and abduction as compared to the nonoperated side were 15 and 10 degrees, respectively. There was no limitation on daily activity, but some little restriction in extreme throwing sports was found. @entity1 included three @entity0 who had bone block resorption and one @entity0 who had superficial wound @entity2 . There was no redislocation nor implant loosening in the study. CONCLUSIONS: This procedure is technically easy, had a low rate of complication, a high degree of @entity0 satisfaction and very effectively prevents redislocation.

title: A modified Bristow procedure for recurrent XXXX .

answer: @entity3


abstract: Culture conditions that lead to swelling and germination dramatically influence cell surface characteristics and properties of @entity0 conidia. Conidial adherence to @entity3 and agglutination markedly increased during swelling, in a time-dependent manner. Agglutination appeared to be sensitive to @entity4 and @entity2 . Removal of cell wall polysaccharides by lyticase or @entity8 suppressed agglutination of conidia. Proteinase K weakly decreased it whereas @entity7 strongly dispersed the cells. These observations suggest that both cell surface @entity6 and proteins are involved in the agglutination process. Electron microscopic observations demonstrated that the cell wall of conidia was subject to some rearrangements during swelling, involving degradation and loss of the external convoluted layer, and subsequent exposure of underlying ligands. This was confirmed using lectins labelled with gold or @entity5 , which showed that some @entity6 , particularly those acting as ligands for peanut agglutinin, are largely exposed during the process. Finally, @entity1 -PAGE revealed major protein changes between resting and swollen conidia. We conclude that the ability of A. fumigatus conidia to aggregate correlates with an increase in adherence and biochemical reorganization of the cell wall.

title: Cell surface properties of XXXX conidia: correlation between adherence, agglutination, and rearrangements of the cell wall.

answer: @entity0


abstract: UNASSIGNED: @entity2 is a @entity0 pathogen whose principal virulence factor is its capsule. This structure allows the bacterium to evade the @entity0 immune system. Treatment of @entity1 caused by this bacterium is based on antibiotics; however, the emergence of antibiotic-resistant strains makes this task increasingly difficult. Therefore, it is necessary to investigate new therapies, such as those based on gold nanoparticles, for which unfortunately the mechanisms involved have not yet been investigated. As far as we know, this study is the first that attempts to explain how gold nanoparticles destroy the bacterium @entity2 . We found that the mean particle size was an important issue, and that the effect on the bacterium was dose-dependent. Cellular growth was inhibited by the presence of the nanoparticles, as was cell viability. The pH of the bacterial growth media was acidified, but interestingly the reactive species were not affected. A transmission electron microscopy analysis revealed the presence of inclusion bodies of gold nanoparticles within the bacterium. We present the first findings that attempt to explain how gold nanoparticles lyse Gram-positive bacteria.

title: Inclusion bodies and pH lowering: as an effect of gold nanoparticles in XXXX .

answer: @entity2


abstract: UNASSIGNED: A group of 107 F1 hybrid @entity2 was used to construct a linkage map using JoinMap 4.0. A total of 4877 microsatellite and single nucleotide polymorphism (SNP) markers isolated from a genomic library (978 microsatellite and 3899 SNP markers) were assigned to construct the genetic map, which comprised 50 linkage groups. The total length of the linkage map for the @entity2 was 4775.90 cM with an average distance between markers of 0.98 cM. Ten quantitative trait loci (QTL) were associated with eye diameter, corresponding to 10.5-57.2% of the total phenotypic variation. Twenty QTL were @entity1 , contributing to 10.8-36.9% of the total phenotypic variation. Two QTL for eye diameter and four @entity1 each accounted for more than 20% of the total phenotypic variation and were considered to be major QTL. One growth factor related to eye diameter was observed on LG10 of the @entity2 genome, and three growth factors @entity1 were observed on LG10, LG35, and LG44 of the @entity2 genome. The significant positive @entity0 with other commercial traits suggests that eye @entity1 can be used to assist in indirect selection for many commercial traits, particularly body weight. Thus, the growth factor for @entity1 may also contribute to the growth of body weight, implying that aggregate breeding could have multiple effects. These findings provide information for future genetic studies and breeding of @entity2 .

title: Genetic analysis of @entity0 in XXXX ( @entity2 L.) using microsatellites and SNPs.

answer: @entity2


abstract: UNASSIGNED: A group of 107 F1 hybrid @entity2 was used to construct a linkage map using JoinMap 4.0. A total of 4877 microsatellite and single nucleotide polymorphism (SNP) markers isolated from a genomic library (978 microsatellite and 3899 SNP markers) were assigned to construct the genetic map, which comprised 50 linkage groups. The total length of the linkage map for the @entity2 was 4775.90 cM with an average distance between markers of 0.98 cM. Ten quantitative trait loci (QTL) were associated with eye diameter, corresponding to 10.5-57.2% of the total phenotypic variation. Twenty QTL were @entity1 , contributing to 10.8-36.9% of the total phenotypic variation. Two QTL for eye diameter and four @entity1 each accounted for more than 20% of the total phenotypic variation and were considered to be major QTL. One growth factor related to eye diameter was observed on LG10 of the @entity2 genome, and three growth factors @entity1 were observed on LG10, LG35, and LG44 of the @entity2 genome. The significant positive @entity0 with other commercial traits suggests that eye @entity1 can be used to assist in indirect selection for many commercial traits, particularly body weight. Thus, the growth factor for @entity1 may also contribute to the growth of body weight, implying that aggregate breeding could have multiple effects. These findings provide information for future genetic studies and breeding of @entity2 .

title: Genetic analysis of @entity0 in @entity2 ( XXXX L.) using microsatellites and SNPs.

answer: @entity2


abstract: UNASSIGNED: A group of 107 F1 hybrid @entity2 was used to construct a linkage map using JoinMap 4.0. A total of 4877 microsatellite and single nucleotide polymorphism (SNP) markers isolated from a genomic library (978 microsatellite and 3899 SNP markers) were assigned to construct the genetic map, which comprised 50 linkage groups. The total length of the linkage map for the @entity2 was 4775.90 cM with an average distance between markers of 0.98 cM. Ten quantitative trait loci (QTL) were associated with eye diameter, corresponding to 10.5-57.2% of the total phenotypic variation. Twenty QTL were @entity1 , contributing to 10.8-36.9% of the total phenotypic variation. Two QTL for eye diameter and four @entity1 each accounted for more than 20% of the total phenotypic variation and were considered to be major QTL. One growth factor related to eye diameter was observed on LG10 of the @entity2 genome, and three growth factors @entity1 were observed on LG10, LG35, and LG44 of the @entity2 genome. The significant positive @entity0 with other commercial traits suggests that eye @entity1 can be used to assist in indirect selection for many commercial traits, particularly body weight. Thus, the growth factor for @entity1 may also contribute to the growth of body weight, implying that aggregate breeding could have multiple effects. These findings provide information for future genetic studies and breeding of @entity2 .

title: Genetic analysis of XXXX in @entity2 ( @entity2 L.) using microsatellites and SNPs.

answer: @entity0


abstract: BACKGROUND: The optimal sequence and extent of multimodality therapy remains to be defined for @entity2 because of its rarity. The purpose of our study was to assess the response to neoadjuvant chemotherapy followed by chemoradiation/radiation in @entity0 with @entity2 . MATERIALS AND METHODS: Four consecutively diagnosed @entity0 were included in this study. The primary @entity1 site was oropharynx in three @entity0 and esophagus in one. The @entity0 with the limited disease were treated with chemotherapy followed by concurrent chemoradiation (n=2) or radiotherapy (n=1). The @entity0 with the extensive disease with the primary site in vallecula was treated with chemotherapy and palliative radiotherapy to the metastatic site. RESULTS: The median follow-up was 22.5 months (range, 8-24 months). Three @entity0 with the limited disease (base of tongue, n=2; esophagus, n=1) were in complete remission. The @entity0 with the extensive disease died of loco-regional @entity1 progression at 8 months from the time of diagnosis. CONCLUSIONS: The combination of chemotherapy and radiotherapy is the preferred therapeutic approach for @entity0 with @entity2 . Induction chemotherapy followed by concurrent chemoradiation or radiation provides a good loco-regional control in @entity0 with limited disease.

title: XXXX - a Case Series of Oropharyngeal and Esophageal Primary Sites Treated with Chemo-Radiotherapy.

answer: @entity2


abstract: BACKGROUND: Although 3D image based brachytherapy is currently the standard of treatment in @entity1 , most of the centres in developing countries still practice orthogonal @entity4 due to financial constraints. The quest for optimum dose and fractionation schedule in @entity3 ( @entity3 ) @entity4 ( @entity4 ) is still ongoing. While the American Brachytherapy Society recommends four to eight fractions of each less than 7.5 Gy, there are some studies demonstrating similar efficacy and comparable @entity2 with higher doses per fraction. OBJECTIVE: To assess the treatment efficacy and late complications of @entity3 @entity4 with 9 Gy per fraction in two fractions. MATERIALS AND METHODS: This is a prospective institutional study in Southern India carried on from 1st June 2012 to 31st July 2014. In this period, 76 @entity0 of @entity1 satisfying our inclusion criteria were treated with concurrent chemo-radiation following @entity4 with 9 Gy per fraction in two fractions, five to seven days apart. RESULTS: The median follow-up period in the study was 24 months (range 10.6 - 31.2 months). The 2 year actuarial local control rate, disease-free survival and overall survival were 88.1%, 84.2% and 81.8% respectively. Although 38.2% @entity0 suffered from late @entity2 , only 3 @entity0 had grade III late @entity2 . CONCLUSIONS: In our experience, @entity3 brachytherapy with 9 Gy per fraction in two fractions is an effective dose fractionation for the treatment of @entity1 with acceptable @entity2 .

title: High Dose Rate Brachytherapy in Two 9 Gy Fractions in the Treatment of Locally Advanced XXXX - a South Indian Institutional Experience.

answer: @entity1


abstract: BACKGROUND: Recent reports have shown that @entity3 is widely expressed in normal tissues and is down- regulated in a wide range of @entity0 @entity2 , suggesting it may act as a @entity2 suppressor gene. We conducted a meta-analysis to determine the correlation between @entity3 expression and clinicopathological characteristics in @entity2 . MATERIALS AND METHODS: A detailed literature search was made for relevant publications from PubMed, EMBASE, Cochrane library databases, Web of Science, CNKI. The methodological quality of the studies was also evaluated. Analyses of pooled data were performed and odds ratios (ORs) were calculated and summarized. RESULTS: Final analysis was performed of 1,815 @entity2 @entity0 from 19 eligible studies. We observed that @entity3 expression was significantly lower in @entity2 than in normal tissues. @entity3 expression was not found to be associated with @entity2 differentiation status. However, @entity3 expression was obviously lower in advance stage than in early-stage @entity2 and was more down-regulated in metastatic than non-metastatic @entity2 . CONCLUSIONS: The results of our meta-analysis suggested that @entity3 expression is significantly lower in @entity2 than in normal tissues. Aberrant @entity3 expression may play an important role in @entity2 genesis and @entity1 .

title: Clinicopathological Significance of XXXX Expression in Cancer: a Meta-Analysis.

answer: @entity3


abstract: OBJECTIVE: The aim was to examine the feasibility, efficiency and safety of adenovirus-mediated in vivo gene transfer into the @entity1 myocardium by a percutaneous transluminal method using a needle-catheter. METHODS: Either a replication-defective adenovirus (Adex1SRLacZL) or a plasmid (pSRLacZ), both expressing @entity3 lacZ coding beta-galactosidase (beta-gal), was directly injected into the left ventricle of @entity1 through a needle-catheter inserted via a femoral artery. Expression of lacZ was examined by histochemical staining and quantified by measuring beta-gal activity. RESULTS: Injections with Adex1SRLacZL induced lacZ expression as a result of 40 out of 41 injections; the expression level was 10 times higher than that obtained with pSRLacZ. Induced beta-gal activity was detected within 24 h, peaked at 7 days and retained for 2 weeks after gene transfer. A repetitive administration of the same adenovirus at 14 days after the first injection also evoked a reduced but significant level of expression despite neutralizing antibodies to adenovirus in serum. Although injection induced an inflammatory response that peaked at 3 days after injection and gradually subsided without a second peak, the temporal change and the extent of @entity0 induced by adenovirus injection was not significantly different from those induced by injection with either saline or plasmid. Neither leakage of enzymes such as CPK or LDH nor alteration in the ECG was detected in the 30 days following gene transfer. CONCLUSIONS: Our findings demonstrate that a catheter-mediated direct injection with an adenovirus can induce gene expression in the ventricle more efficiently without additional @entity2 and @entity0 compared with injection with a plasmid. A repeat dose of the same adenovirus elicited gene expression at an attenuated but significant level. This method may potentially have clinical applications: in modifying @entity2 and/or improving general circulation under certain circumstances.

title: Percutaneous transluminal gene transfer into XXXX myocardium in vivo by replication-defective adenovirus.

answer: @entity1


abstract: BACKGROUND: The organ preservation approach of choice for the treatment of locally advanced @entity2 is concurrent chemoradiation with three weekly high doses of @entity5 . Although this is an efficacious treatment policy, it has high @entity4 , which lead to frequent treatment breaks and increased overall treatment time. Hence, the current study was undertaken to evaluate the efficacy of concurrent chemoradiation using 40 mg/m2 weekly @entity5 . MATERIALS AND METHODS: This is a single institutional retrospective study including the data of 266 locally advanced @entity2 @entity0 who were treated with concurrent chemoradiation using 40 mg/m2 weekly @entity5 from January 2012 to January 2014. A p-value of < 0.05 was taken to be significant statistically for all purposes in the study. RESULTS: The mean age of the study @entity0 was 48.8 years. Some 36.1% of the @entity0 had oral cavity primary @entity1 . The mean overall treatment time was 57.2 days. With a mean follow up of 15.2 months for all study @entity0 and 17.5 months for survivors, 3 year local control, locoregional control and disease free survival were seen in 62.8%, 42.8% and 42.1% of the study @entity0 . Primary @entity1 site, nodal stage of disease, AJCC stage of the disease and number of cycles of weekly @entity5 demonstrated statistically significant correlations with 3 year local control, locoregional control and disease free survival. CONCLUSIONS: Concurrent chemoradiotherapy with moderate dose weekly @entity5 is an efficacious treatment regime for locally advanced @entity2 with tolerable @entity3 which can be used in developing countries with limited resources.

title: Weekly XXXX -Based Concurrent Chemoradiotherapy for Treatment of Locally Advanced @entity2 : a Single Institution Study.

answer: @entity5


abstract: BACKGROUND: The organ preservation approach of choice for the treatment of locally advanced @entity2 is concurrent chemoradiation with three weekly high doses of @entity5 . Although this is an efficacious treatment policy, it has high @entity4 , which lead to frequent treatment breaks and increased overall treatment time. Hence, the current study was undertaken to evaluate the efficacy of concurrent chemoradiation using 40 mg/m2 weekly @entity5 . MATERIALS AND METHODS: This is a single institutional retrospective study including the data of 266 locally advanced @entity2 @entity0 who were treated with concurrent chemoradiation using 40 mg/m2 weekly @entity5 from January 2012 to January 2014. A p-value of < 0.05 was taken to be significant statistically for all purposes in the study. RESULTS: The mean age of the study @entity0 was 48.8 years. Some 36.1% of the @entity0 had oral cavity primary @entity1 . The mean overall treatment time was 57.2 days. With a mean follow up of 15.2 months for all study @entity0 and 17.5 months for survivors, 3 year local control, locoregional control and disease free survival were seen in 62.8%, 42.8% and 42.1% of the study @entity0 . Primary @entity1 site, nodal stage of disease, AJCC stage of the disease and number of cycles of weekly @entity5 demonstrated statistically significant correlations with 3 year local control, locoregional control and disease free survival. CONCLUSIONS: Concurrent chemoradiotherapy with moderate dose weekly @entity5 is an efficacious treatment regime for locally advanced @entity2 with tolerable @entity3 which can be used in developing countries with limited resources.

title: Weekly @entity5 -Based Concurrent Chemoradiotherapy for Treatment of Locally Advanced XXXX : a Single Institution Study.

answer: @entity2


abstract: PURPOSE: Most of what we know about adipose tissue is restricted to observations derived after an overnight fast. However, @entity0 spend the majority of waking hours in a postprandial (fed) state, and it is unclear whether increasing @entity4 impacts adipose tissue responses to feeding. The aim of this research was to investigate postprandial responses in adipose tissue across varying degrees of @entity4 . METHODS: Thirty males aged 35-55  years with waist circumference 81-118  cm were divided equally into groups categorized as either lean, overweight or @entity1 . @entity0 consumed a meal and insulinaemic, glycaemic and lipidaemic responses were monitored over 6  h. Subcutaneous adipose tissue samples were obtained at baseline and after 6  h to examine changes in gene expression and adipose tissue secretion of various adipokines. RESULTS: Following consumption of the meal, @entity5 and @entity2 responses were higher with increased @entity4 (total AUC effects of group; p  =  0.058 and p  =  0.027, respectively). At 6  h, significant time effects reflected increases in @entity3 (F  =  14.7, p  =  0.001) and @entity6 (F  =  10.7, p  =  0.003) and reduction in @entity7 adipose tissue gene expression (F  =  24.6, p  <  0.001), all independent of @entity4 . Ex vivo adipokine secretion from adipose tissue explants remained largely unchanged after feeding. CONCLUSIONS: Increased systemic measures of postprandial metabolism with greater @entity4 do not translate into increased inflammatory responses within adipose tissue. Instead, postprandial adipose tissue changes may represent a normal response to feeding or a (relatively) normalized response with increased @entity4 due to either similar net exposure (i.e. per g of adipose) or reduced adipose tissue responsiveness.

title: Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and XXXX @entity0 .

answer: @entity1


abstract: PURPOSE: Most of what we know about adipose tissue is restricted to observations derived after an overnight fast. However, @entity0 spend the majority of waking hours in a postprandial (fed) state, and it is unclear whether increasing @entity4 impacts adipose tissue responses to feeding. The aim of this research was to investigate postprandial responses in adipose tissue across varying degrees of @entity4 . METHODS: Thirty males aged 35-55  years with waist circumference 81-118  cm were divided equally into groups categorized as either lean, overweight or @entity1 . @entity0 consumed a meal and insulinaemic, glycaemic and lipidaemic responses were monitored over 6  h. Subcutaneous adipose tissue samples were obtained at baseline and after 6  h to examine changes in gene expression and adipose tissue secretion of various adipokines. RESULTS: Following consumption of the meal, @entity5 and @entity2 responses were higher with increased @entity4 (total AUC effects of group; p  =  0.058 and p  =  0.027, respectively). At 6  h, significant time effects reflected increases in @entity3 (F  =  14.7, p  =  0.001) and @entity6 (F  =  10.7, p  =  0.003) and reduction in @entity7 adipose tissue gene expression (F  =  24.6, p  <  0.001), all independent of @entity4 . Ex vivo adipokine secretion from adipose tissue explants remained largely unchanged after feeding. CONCLUSIONS: Increased systemic measures of postprandial metabolism with greater @entity4 do not translate into increased inflammatory responses within adipose tissue. Instead, postprandial adipose tissue changes may represent a normal response to feeding or a (relatively) normalized response with increased @entity4 due to either similar net exposure (i.e. per g of adipose) or reduced adipose tissue responsiveness.

title: Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and @entity1 XXXX .

answer: @entity0


abstract: UNASSIGNED: This study evaluated the clinical efficacy and value of computed tomography (CT)-guided percutaneous microwave ablation therapy (PMAT) for @entity1 without surgical treatment. A total of 39 lesions in 29 @entity0 with @entity1 were treated by CT-guided PMAT under local anesthesia. The microwave energy was 50-70 W at a frequency of 2450 MHz. The treatment was performed by using 1 or 2 points of ablation emission according to the size and shape of the @entity2 . Operations were completed in 29 @entity0 . The average operating time was 8 min (range: 5-12 min). After PMAT, lower density in the ablated area was observed by CT. Pre- and post-treatment CT values were 52.60 and 26.12 Hu, respectively. Eight, 14, 4, and 3 @entity0 achieved complete remission, partial remission, stable status, and progression, respectively, for an effectiveness rate of 75.86%. Complications included 5, 2, and 15 cases of pneumothorax, @entity3 , and fever, respectively. No needle track implantation was observed. Mean progression-free survival was 14.6 months. The 1- and 2-year survival rates were 91.3 and 82.6%, respectively. Thus, PMAT is a minimally invasive, safe, and effective treatment for @entity1 . It can improve quality of life, prolong survival, and improve the survival rate.

title: Computed tomography-guided percutaneous microwave ablation therapy for XXXX .

answer: @entity1


abstract: PURPOSE: Recent studies report systematic differences in how individuals categorize the severity of identical health and work limitation vignettes. We investigate how health professionals and disability recipients characterize the severity of work limitations and whether their reporting patterns are robust to demographic, education, and health characteristics. We use the results to illustrate the potential impact of reporting heterogeneity on the distribution of work disability estimated from self-reported categorical health and disability data. METHOD: Nationally representative data on anchoring disability vignettes from the 2004 @entity3 ( @entity3 ) are used to investigate how respondents with an occupation background in health and Social Security disability beneficiaries categorize work limitation vignettes. Using @entity2 , @entity1 , and @entity4 vignettes, we estimate generalized ordered probit models (N = 2,660 individuals or 39,681 @entity0 -vignette observations) that allow the severity thresholds to vary by respondent characteristics. RESULTS: We find that health professionals (excluding nurses) and disability recipients tend to classify identical work limitations as more severe compared to non-health professional non-disabled respondents. For disability recipients, the differences are most pronounced and particularly visible in the tails of the work limitations distribution. For health professionals, we observe smaller differences, affecting primarily the classification of mildly and moderately severe work limitations. The patterns for health professionals (excluding nurses) are robust to demographics, education, and health conditions. The greater likelihood of viewing the vignette @entity0 as more severely work limited observed among disability recipients is mostly explained by the fact that these respondents also tend to be in poorer health which itself predicts a more inclusive scale. CONCLUSIONS: Knowledge of reporting scales from health professionals and disabled individuals can benefit researchers in a broad range of applications in health and disability research. They may be useful as reference scales to evaluate disability survey data. Such knowledge may be beneficial when studying disability programs. Given the increasing availability of anchoring vignette data in surveys, this is a promising area for future evaluation research.

title: Anchoring Vignettes in the XXXX : How Do Medical Professionals and Disability Recipients Characterize the Severity of Work Limitations?

answer: @entity3


abstract: UNASSIGNED: All components of the endothelin (ET) system are present in renal tubular cells. In this review, we summarize current knowledge about ET and the most common tubular diseases: @entity4 ( @entity4 ) and @entity1 . @entity4 originally was called @entity8 , pointing to the most prominent morphologic findings. Similarly, cysts in @entity1 , and especially in @entity1 , are of tubular origin. Preclinical studies have indicated that the ET system and particularly @entity7 receptors are involved in the pathogenesis of @entity2 -reperfusion injury, although these findings have not been translated to clinical studies. The ET system also has been implicated in radiocontrast-dye-induced @entity4 , however, ET-receptor blockade in a large @entity0 study was not successful. The ET system is activated in @entity3 models of @entity4 ; the effectiveness of ET blocking agents in preclinical studies is variable depending on the model and the ET-receptor antagonist used. Numerous studies have shown that the ET system plays an important role in the complex pathophysiology associated with @entity1 . However, results from selective targeting of ET-receptor subtypes in animal models of @entity1 have proved disappointing and do not support clinical trials. These studies have shown that a critical balance between @entity7 and @entity5 receptor action is necessary to maintain structure and function in the @entity9 . In summary, ETs have been implicated in the pathogenesis of several renal @entity6 , however, experimental animal findings have not yet led to use of ET blockers in @entity0 beings.

title: Endothelin and XXXX .

answer: @entity1


abstract: OBJECTIVES: Medical treatment of complicated @entity4 or @entity5 in @entity6 patients includes antibiotics and @entity3 . Intrapleural fibrinolysis may facilitate @entity3 ; however, there is a lack of consensus regarding the optimal dosing regimen. The primary purpose of this study was to evaluate the efficacy and safety of a large-dose intrapleural alteplase regimen in @entity6 @entity0 . Secondarily, this investigation sought to differentiate the clinical characteristics of responders and non-responders to intrapleural alteplase therapy. METHODS: All @entity0 with parapneumonic effusions treated with intrapleural alteplase between June 2003 and December 2011 were reviewed retrospectively. Efficacy was assessed by comparing chest tube output, in mL/hr and mL/kg/hr, for 24 hours before and after the first dose of alteplase. Additional efficacy outcomes included duration of in situ chest tubes, a need for surgical intervention for @entity4 , and length of hospital stay. Safety was assessed by frequency and severity of adverse events. Non-responders and responders were compared based on demographic and disease characteristics. Responders were defined as @entity0 who did not require surgical intervention after intrapleural alteplase therapy. RESULTS: Seventy-three @entity0 , aged 0.5 to 22.5 years, received intrapleural alteplase to facilitate @entity3 . Median alteplase dose was 7 mg (range, 3 to 10 mg; median 0.38 mg/kg). Chest tube output increased from 10.7 to 24.2 mL/hr (p = 0.006), and median length of hospital stay was 9 days. Eighty-four percent of @entity0 were responders. The most common adverse events were @entity2 (20.5%) and @entity1 desaturation greater than 10% from baseline (16.4%). High-flow nasal cannula was the most common intervention for @entity1 desaturation to 80% to 90%. Nine @entity0 (12%) required a blood transfusion during the study. CONCLUSION: Large-dose intrapleural alteplase is effective in facilitating @entity3 in @entity6 @entity0 with complicated @entity4 or @entity5 . Common adverse effects include @entity2 and @entity1 desaturation. The potential for bleeding warrants clinical monitoring.

title: Retrospective analysis of large-dose intrapleural alteplase for complicated XXXX @entity4 and @entity5 .

answer: @entity6


abstract: OBJECTIVES: Medical treatment of complicated @entity4 or @entity5 in @entity6 patients includes antibiotics and @entity3 . Intrapleural fibrinolysis may facilitate @entity3 ; however, there is a lack of consensus regarding the optimal dosing regimen. The primary purpose of this study was to evaluate the efficacy and safety of a large-dose intrapleural alteplase regimen in @entity6 @entity0 . Secondarily, this investigation sought to differentiate the clinical characteristics of responders and non-responders to intrapleural alteplase therapy. METHODS: All @entity0 with parapneumonic effusions treated with intrapleural alteplase between June 2003 and December 2011 were reviewed retrospectively. Efficacy was assessed by comparing chest tube output, in mL/hr and mL/kg/hr, for 24 hours before and after the first dose of alteplase. Additional efficacy outcomes included duration of in situ chest tubes, a need for surgical intervention for @entity4 , and length of hospital stay. Safety was assessed by frequency and severity of adverse events. Non-responders and responders were compared based on demographic and disease characteristics. Responders were defined as @entity0 who did not require surgical intervention after intrapleural alteplase therapy. RESULTS: Seventy-three @entity0 , aged 0.5 to 22.5 years, received intrapleural alteplase to facilitate @entity3 . Median alteplase dose was 7 mg (range, 3 to 10 mg; median 0.38 mg/kg). Chest tube output increased from 10.7 to 24.2 mL/hr (p = 0.006), and median length of hospital stay was 9 days. Eighty-four percent of @entity0 were responders. The most common adverse events were @entity2 (20.5%) and @entity1 desaturation greater than 10% from baseline (16.4%). High-flow nasal cannula was the most common intervention for @entity1 desaturation to 80% to 90%. Nine @entity0 (12%) required a blood transfusion during the study. CONCLUSION: Large-dose intrapleural alteplase is effective in facilitating @entity3 in @entity6 @entity0 with complicated @entity4 or @entity5 . Common adverse effects include @entity2 and @entity1 desaturation. The potential for bleeding warrants clinical monitoring.

title: Retrospective analysis of large-dose intrapleural alteplase for complicated @entity6 @entity4 and XXXX .

answer: @entity5


abstract: OBJECTIVES: Medical treatment of complicated @entity4 or @entity5 in @entity6 patients includes antibiotics and @entity3 . Intrapleural fibrinolysis may facilitate @entity3 ; however, there is a lack of consensus regarding the optimal dosing regimen. The primary purpose of this study was to evaluate the efficacy and safety of a large-dose intrapleural alteplase regimen in @entity6 @entity0 . Secondarily, this investigation sought to differentiate the clinical characteristics of responders and non-responders to intrapleural alteplase therapy. METHODS: All @entity0 with parapneumonic effusions treated with intrapleural alteplase between June 2003 and December 2011 were reviewed retrospectively. Efficacy was assessed by comparing chest tube output, in mL/hr and mL/kg/hr, for 24 hours before and after the first dose of alteplase. Additional efficacy outcomes included duration of in situ chest tubes, a need for surgical intervention for @entity4 , and length of hospital stay. Safety was assessed by frequency and severity of adverse events. Non-responders and responders were compared based on demographic and disease characteristics. Responders were defined as @entity0 who did not require surgical intervention after intrapleural alteplase therapy. RESULTS: Seventy-three @entity0 , aged 0.5 to 22.5 years, received intrapleural alteplase to facilitate @entity3 . Median alteplase dose was 7 mg (range, 3 to 10 mg; median 0.38 mg/kg). Chest tube output increased from 10.7 to 24.2 mL/hr (p = 0.006), and median length of hospital stay was 9 days. Eighty-four percent of @entity0 were responders. The most common adverse events were @entity2 (20.5%) and @entity1 desaturation greater than 10% from baseline (16.4%). High-flow nasal cannula was the most common intervention for @entity1 desaturation to 80% to 90%. Nine @entity0 (12%) required a blood transfusion during the study. CONCLUSION: Large-dose intrapleural alteplase is effective in facilitating @entity3 in @entity6 @entity0 with complicated @entity4 or @entity5 . Common adverse effects include @entity2 and @entity1 desaturation. The potential for bleeding warrants clinical monitoring.

title: Retrospective analysis of large-dose intrapleural alteplase for complicated @entity6 XXXX and @entity5 .

answer: @entity4


abstract: INTRODUCTION: Ductoscopy is a low invasive method enabling the diagnostics of @entity2 in breasts. Fiberoptic ductoscopy (FDS) is important in the diagnosis of @entity1 with pathological nipple discharge. There are attempts to apply FDS in @entity1 with @entity0 without the presence of nipple discharge. AIM: To assess fiberoptic ductoscopy in the diagnostics of @entity0 . MATERIAL AND METHODS: The material was composed of a group of 164 @entity1 treated for @entity2 in breasts. In the analyzed group of @entity1 , FDS was conducted in 128 @entity1 with pathological nipple discharge and 36 @entity1 with the presence of @entity0 . The analyzed period was divided into three sub-periods. Sensitivity, specificity, positive predictive value ( @entity3 ) and negative predictive value (NPV) of FDS examination verified by post-operative histopathological examination were analyzed. The safety of the method was also assessed, taking into consideration the complications. RESULTS: An increasing number of successful ductoscopies together with the number of performed FDS examinations was noted. There were statistically significant differences in the percentage of successful cannulations in relation to the number of performed FDS examinations in the three subsequent stages of the project (p = 0.011). The duration of FDS examination in the third period was reduced in comparison with the first and second period (p < 0.001). Sensitivity of fiberoptic ductoscopy is 68.1%, specificity 77.3% and @entity3 90.4%, but NPV is 44.1%. CONCLUSIONS: The introduction of fiberoptic ductoscopy in our clinic has contributed to the widening of the diagnostic possibilities of small intraductal lesions of the mammary gland.

title: The significance of ductoscopy of mammary ducts in the diagnostics of XXXX .

answer: @entity0


abstract: UNASSIGNED: Three BRI protein family members have been identified. Among these are @entity3 and @entity4 , the latter is associated with Familial Danish and Familial British @entity1 . 'In silico' sequence analysis identified putative @entity5 binding sites in @entity4 and @entity3 . This is singularly important, given that protein phosphorylation is a major mechanism regulating intracellular processes. @entity5 ( @entity5 ) interacting proteins (PIPs) are fundamental in determining substrate specificity and subcellular localization of this phosphatase. More than 200 PIPs have thus far been reported. Both @entity4 and @entity3 are type II transmembrane glycoproteins relevant in neuronal systems. Using Myc- @entity4 and Myc- @entity3 , wild type and @entity5 binding mutant constructs, it was possible to show, for the first time, that in fact @entity4 and @entity3 bind @entity5 . The complexes @entity4 : @entity5 and @entity3 : @entity5 were validated in vitro and in vivo. The subcellular distribution of @entity4 and @entity3 is similar; both localize to the perinuclear area and Golgi apparatus in non-neuronal cells. However, in SH-SY5Y cells, @entity4 and @entity3 could also be detected in elongated cellular projections ('processes') and in @entity0 cortical neurons both are broadly distributed throughout the cell body, @entity2 and the nucleus. Consistently, co-localization of @entity4 and @entity3 with @entity5 was evident. The functional significance of these complexes is apparent given that both BRI proteins are substrates of @entity5 , thus simultaneously this is the first report of @entity4 and @entity3 as phosphoproteins. Moreover, we show that when @entity4 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident. Interestingly, the Alzheimer's amyloid precursor protein (APP), forms a trimeric complex composed of @entity5 and Fe65, with @entity5 having the capacity to dephosphorylate APP at Thr668 residue. The emerging consensus appears to be that @entity5 containing complexes are crucial in regulating signaling events underlying neuropathological conditions.

title: XXXX and @entity3 are functionally distinct phosphoproteins.

answer: @entity4


abstract: UNASSIGNED: Three BRI protein family members have been identified. Among these are @entity3 and @entity4 , the latter is associated with Familial Danish and Familial British @entity1 . 'In silico' sequence analysis identified putative @entity5 binding sites in @entity4 and @entity3 . This is singularly important, given that protein phosphorylation is a major mechanism regulating intracellular processes. @entity5 ( @entity5 ) interacting proteins (PIPs) are fundamental in determining substrate specificity and subcellular localization of this phosphatase. More than 200 PIPs have thus far been reported. Both @entity4 and @entity3 are type II transmembrane glycoproteins relevant in neuronal systems. Using Myc- @entity4 and Myc- @entity3 , wild type and @entity5 binding mutant constructs, it was possible to show, for the first time, that in fact @entity4 and @entity3 bind @entity5 . The complexes @entity4 : @entity5 and @entity3 : @entity5 were validated in vitro and in vivo. The subcellular distribution of @entity4 and @entity3 is similar; both localize to the perinuclear area and Golgi apparatus in non-neuronal cells. However, in SH-SY5Y cells, @entity4 and @entity3 could also be detected in elongated cellular projections ('processes') and in @entity0 cortical neurons both are broadly distributed throughout the cell body, @entity2 and the nucleus. Consistently, co-localization of @entity4 and @entity3 with @entity5 was evident. The functional significance of these complexes is apparent given that both BRI proteins are substrates of @entity5 , thus simultaneously this is the first report of @entity4 and @entity3 as phosphoproteins. Moreover, we show that when @entity4 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident. Interestingly, the Alzheimer's amyloid precursor protein (APP), forms a trimeric complex composed of @entity5 and Fe65, with @entity5 having the capacity to dephosphorylate APP at Thr668 residue. The emerging consensus appears to be that @entity5 containing complexes are crucial in regulating signaling events underlying neuropathological conditions.

title: @entity4 and XXXX are functionally distinct phosphoproteins.

answer: @entity3


abstract: UNASSIGNED: Vagus nerve stimulation (VNS) is a widely used adjunctive treatment option for intractable @entity2 . Most studies have demonstrated short-term @entity3 outcomes, usually for up to 5years, and thus far, none have reported psychosocial outcomes in adults. We aimed to assess long-term @entity3 and psychosocial outcomes in @entity0 with intractable @entity2 on VNS therapy for more than 15years. We identified @entity0 who had VNS implantation for treatment of intractable @entity2 from 1997 to 2013 at our Comprehensive @entity2 Program and gathered demographics including age at @entity2 onset and VNS implantation, @entity2 type, number of @entity4 ( @entity4 ) and @entity3 frequency before VNS implantation and at the last clinic visit, and the most recent stimulation parameters from electronic medical records (EMR). Phone surveys were conducted by research assistants from May to November 2014 to determine @entity0 ' current @entity3 frequency and psychosocial metrics, including driving, employment status, and use of antidepressants. @entity3 outcomes were based on modified Engel classification (I: @entity3 -free/rare simple partial @entity3 ; II: >90% @entity3 reduction (SR), III: 50-90% SR, IV: <50% SR; classes I to III (>50% SR)=favorable outcome). A total of 207 @entity0 underwent VNS implantation, 15 of whom were deceased at the time of the phone survey, and 40 had incomplete data for medical abstraction. Of the remaining 152, 90 (59%) were contacted and completed the survey. Of these, 51% were male, with the mean age at @entity2 onset of 9.4years (range: birth to 60years). There were 35 (39%) @entity0 with @entity2 , 19 (21%) with temporal, 18 (20%) with symptomatic generalized, 5 (6%) with idiopathic generalized, and 13 (14%) with multiple types. Final VNS settings showed 16 (18%) @entity0 with an output current >2mA and 14 (16%) with rapid cycling. Of the 80 @entity0 with @entity3 frequency information, 16 (20%) had a modified Engel class I outcome, 14 (18%) had class II, 24 (30%) had class III, and 26 (33%) had class IV. Eighty percent said having VNS was worthwhile. Among the 90 @entity0 , 43 @entity0 were >= 18years old without @entity1 in whom psychosocial outcomes were further analyzed. There was a decrease in the number of @entity0 driving (31% vs 14%, p=0.052) and working (44% vs 35%, p=0.285) and an increase in the number of patients using antidepressant medication (14% vs 28%, p=0.057) at the time of survey compared to before VNS. In this subset, @entity0 with >50% SR (60%) were taking significantly fewer @entity4 at the time of survey compared to @entity0 with unfavorable outcomes (median: 3 vs 4, p=0.045). The associations of >50% SR with the psychosocial outcomes of driving, employment, and antidepressant use were not significant, although 77% of this subset said VNS was worthwhile. This is the first study that assesses both @entity3 and psychosocial outcomes, and demonstrates favorable @entity3 outcomes of >50% SR in 68% of @entity0 and @entity3 freedom in 20% of @entity0 . A large majority of @entity0 (80%) considered VNS therapy worthwhile regardless of @entity2 type and psychosocial outcomes.

title: Long-term XXXX and psychosocial outcomes of vagus nerve stimulation for intractable @entity2 .

answer: @entity3


abstract: UNASSIGNED: Vagus nerve stimulation (VNS) is a widely used adjunctive treatment option for intractable @entity2 . Most studies have demonstrated short-term @entity3 outcomes, usually for up to 5years, and thus far, none have reported psychosocial outcomes in adults. We aimed to assess long-term @entity3 and psychosocial outcomes in @entity0 with intractable @entity2 on VNS therapy for more than 15years. We identified @entity0 who had VNS implantation for treatment of intractable @entity2 from 1997 to 2013 at our Comprehensive @entity2 Program and gathered demographics including age at @entity2 onset and VNS implantation, @entity2 type, number of @entity4 ( @entity4 ) and @entity3 frequency before VNS implantation and at the last clinic visit, and the most recent stimulation parameters from electronic medical records (EMR). Phone surveys were conducted by research assistants from May to November 2014 to determine @entity0 ' current @entity3 frequency and psychosocial metrics, including driving, employment status, and use of antidepressants. @entity3 outcomes were based on modified Engel classification (I: @entity3 -free/rare simple partial @entity3 ; II: >90% @entity3 reduction (SR), III: 50-90% SR, IV: <50% SR; classes I to III (>50% SR)=favorable outcome). A total of 207 @entity0 underwent VNS implantation, 15 of whom were deceased at the time of the phone survey, and 40 had incomplete data for medical abstraction. Of the remaining 152, 90 (59%) were contacted and completed the survey. Of these, 51% were male, with the mean age at @entity2 onset of 9.4years (range: birth to 60years). There were 35 (39%) @entity0 with @entity2 , 19 (21%) with temporal, 18 (20%) with symptomatic generalized, 5 (6%) with idiopathic generalized, and 13 (14%) with multiple types. Final VNS settings showed 16 (18%) @entity0 with an output current >2mA and 14 (16%) with rapid cycling. Of the 80 @entity0 with @entity3 frequency information, 16 (20%) had a modified Engel class I outcome, 14 (18%) had class II, 24 (30%) had class III, and 26 (33%) had class IV. Eighty percent said having VNS was worthwhile. Among the 90 @entity0 , 43 @entity0 were >= 18years old without @entity1 in whom psychosocial outcomes were further analyzed. There was a decrease in the number of @entity0 driving (31% vs 14%, p=0.052) and working (44% vs 35%, p=0.285) and an increase in the number of patients using antidepressant medication (14% vs 28%, p=0.057) at the time of survey compared to before VNS. In this subset, @entity0 with >50% SR (60%) were taking significantly fewer @entity4 at the time of survey compared to @entity0 with unfavorable outcomes (median: 3 vs 4, p=0.045). The associations of >50% SR with the psychosocial outcomes of driving, employment, and antidepressant use were not significant, although 77% of this subset said VNS was worthwhile. This is the first study that assesses both @entity3 and psychosocial outcomes, and demonstrates favorable @entity3 outcomes of >50% SR in 68% of @entity0 and @entity3 freedom in 20% of @entity0 . A large majority of @entity0 (80%) considered VNS therapy worthwhile regardless of @entity2 type and psychosocial outcomes.

title: Long-term @entity3 and psychosocial outcomes of vagus nerve stimulation for intractable XXXX .

answer: @entity2


abstract: AIM: To assess the role of @entity7 ( @entity7 ) for the treatment of highly complex @entity6 . METHODS: Overall, 96 Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification score 10 to 13 @entity6 were treated with @entity7 at our institution. All conventional perioperative variables, surgical, functional and oncological results were gathered in a prospectively maintained database. Survival curves were generated using a Kaplan-Meier method. Univariate analysis assessed the outcome differences. RESULTS: Mean (  1s.d.) clinical @entity1 diameter was 4.8 (  1.6  cm). 70.8% of @entity0 had >= cT1b stage. The PADUA score was recorded as 10, 11, 12 and 13 in 57.3%, 29.2%, 11.5%, and 2.1% of @entity1 respectively. Overall, 76 @entity0 were treated with an open approach and 20 robotically. Mean warm @entity2 time (WIT) was 19.2  min, and WIT greater than 25  min occurred in 14.6% of cases. Positive surgical margin (PSM) rate was 3.6% and trifecta was achieved in 64.3% of @entity0 . @entity4 occurred in 24% of @entity0 , with 14.6% Clavien-Dindo grade 1-2, 8.3% grade 3, and 1% grade 4. Five-year cancer specific survival (CSS), recurrent free survival (RFS), and overall survival (OS) rates resulted 96.1%, 90.8% and 88.0%, respectively. Overall, 4.2% of @entity0 experienced @entity3 . At follow-up, the mean decrease of @entity5 from preoperative value was 13.9  ml/min. This was not significantly correlated with PADUA score (p  =  0.69). The surgical approach was neither a predictor of Trifecta outcome, nor of @entity4 , WIT >25  min or PSM rate. CONCLUSIONS: @entity7 is an effective treatment for @entity6 , with a potential key role to widen the NSS (nephron sparing surgery) indications according to guidelines.

title: Simple enucleation for the treatment of highly complex XXXX : Perioperative, functional and oncological results.

answer: @entity6


abstract: BACKGROUND: Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in @entity0 . Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk. METHODS: The analysis was performed within the European Investigation into @entity1 and Nutrition prospective cohort study, which enrolled >500,000 @entity0 and @entity0 from 1992 to 2000, who were residing in a given town/geographic area in 10 European countries. The current analysis included 322,972 eligible @entity0 aged 25-70 years with 99  % complete follow-up for vital status. We assessed reproductive characteristics reported at the study baseline including parity, age at the first birth, breastfeeding, @entity3 , oral contraceptive use, age at menarche and menopause, total ovulatory years, and history of oophorectomy/hysterectomy. Hazard ratios (HRs) and 95  % confidence intervals (CIs) for mortality were determined using Cox proportional hazards regression models adjusted for menopausal status, body mass index, physical activity, education level, and smoking status/intensity and duration. RESULTS: During a mean follow-up of 12.9  years, 14,383 @entity2 occurred. The HR (95  % CI) for risk of all-cause mortality was lower in parous versus nulliparous @entity0 (0.80; 0.76-0.84), in @entity0 who had ever versus never breastfed (0.92; 0.87-0.97), in ever versus never users of oral contraceptives (among non-smokers; 0.90; 0.86-0.95), and in @entity0 reporting a later age at menarche (>= 15  years versus <12; 0.90; 0.85-0.96; P for trend   =   0.038). CONCLUSIONS: Childbirth, breastfeeding, oral contraceptive use, and a later age at menarche were associated with better health outcomes. These findings may contribute to the development of improved strategies to promote better long-term health in @entity0 .

title: Reproductive factors and risk of mortality in the European Prospective Investigation into XXXX and Nutrition; a cohort study.

answer: @entity1


abstract: OBJECTIVE: To study the growth and speech outcomes in @entity0 who were operated on for @entity2 ( @entity2 ) by a single surgeon using two different treatment protocols. MATERIAL AND METHODS: A total of 200 consecutive @entity0 with nonsyndromic @entity2 were randomly allocated to two different treatment protocols. Of the 200 @entity0 , 179 completed the protocol. However, only 85 @entity0 presented for follow-up during the mixed dentition period (7-10 years of age). The  following treatment protocol was followed. Protocol 1 consisted of the vomer flap (VF), whereby @entity0 underwent primary lip nose repair and vomer flap for hard palate single-layer closure, followed by soft palate repair 6 months later; Protocol 2 consisted of the two-flap technique (TF), whereby the @entity1 ( @entity1 ) was repaired by two-flap technique after primary lip and nose repair. GOSLON Yardstick scores for dental arch relation, and speech outcomes based on universal reporting parameters, were noted. RESULTS: A total of 40 @entity0 in the VF group and 45 in the TF group completed the treatment protocols. The GOSLON scores showed marginally better outcomes in the VF group compared to the TF group. Statistically significant differences were found only in two speech parameters, with better outcomes in the TF group. CONCLUSIONS: Our results showed marginally better growth outcome in the VF group compared to the TF group. However, the speech outcomes were better in the TF group.

title: A randomized controlled trial comparing two techniques for XXXX : Growth and speech outcomes during mixed dentition.

answer: @entity2


abstract: @entity2 (FA), a ubiquitous environmental pollutant, has long been suspected of having male reproductive @entity1 . However, FA male reproductive @entity1 was inconclusive due to dearth of @entity0 studies. Therefore, we sought to investigate whether occupational exposure to FA affects semen quality. Semen quality including five conventional parameters and seven kinematics parameters were compared between 114 male workers occupationally exposed to FA and 76 referents. FA exposure index (FEI) was measured and calculated. Our results showed that sperm progressive motility, @entity3 , @entity4 , VSL and VAP were statistically significant decreased in FA exposure workers compared with the referents. Moreover, FEI was significantly negative associated with sperm progressive motility (b   =   -0.19, P   =   0.01) and @entity3 (b   =   -0.23, P   =   0.004). In addition, a significant elevated risk of abnormal sperm progressive motility were observed in both low- (OR   =   2.58; 95%   CI: 1.11-5.97) and high-FA-exposed group (OR   =   3.41; 95%   CI: 1.45-7.92) respectively. Furthermore, a significant increased risk was also estimated for abnormal @entity3 in both low- (OR   =   3.21; 95%   CI: 1.24-8.28) and high-FA-exposed group (OR   =   4.84; 95%   CI: 1.83-12.81) respectively. In conclusion, our study revealed the adverse effects of FA occupation exposure on semen quality, especially on sperm motion parameters.

title: Associations between occupation exposure to XXXX and semen quality, a primary study.

answer: @entity2


abstract: BACKGROUND CONTEXT: Intraoperative reduction of low-grade lumbar spondylolisthesis (LGLS) remains disputed. There is currently no published data comparing midterm outcomes of reduction versus in situ fusion. PURPOSE: This study aimed to compare mid-term clinical, radiological, and perioperative outcomes for reduction versus in situ fusion in LGLS with @entity5 . STUDY DESIGN/SETTING: A retrospective review of prospectively collected spine registry data in a single institution was carried out. @entity0 SAMPLE: All @entity0 who underwent minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) for LGLS with @entity5 with a minimum 5-year follow-up comprised the @entity0 sample. OUTCOME MEASURES: Self-reported measures were @entity4 Index, North American Spine Society Neurogenic Symptom Score, Health Outcomes Survey Short Form-36 score, and Numerical Pain Rating Scale (back and leg @entity1 ). Radiological outcomes were fusion grading, @entity3 ( @entity3 ), and implant failure or loosening. Perioperative outcomes were fluoroscopic time, operative time, intraoperative @entity2 , opioid analgesia usage, time to ambulation, duration of hospitalization, and complication rate. Functional outcomes were @entity0 satisfaction rate and rate of return to full function. METHODS: A retrospective review was performed on prospectively collected registry data of @entity0 undergoing MIS TLIF for LGLS with @entity5 , from 2004 to 2009. The operative technique and postoperative protocol were standardized. Two groups were formed based on complete reduction of the spondylolisthesis (reduction group [RG]) or the lack thereof (non-reduction group [NRG]) in the immediate postoperative radiograph. Outcomes at baseline, 6 months, 2 years, and 5 years postsurgery were compared. RESULTS: There were 56 @entity0 included (RG=30, NRG=26). The two groups had comparable baseline characteristics: demographics, body mass index, spondylolisthesis etiology, spinal level involved, bone graft and bone morphogenetic protein used, and all self-reported outcome measures. Perioperative outcomes were not significantly different. The early complication rate (RG=3.3%, NRG=19.2%, p=.086) and late complication rate (RG=10%, NRG=23.1%, p=.184) were similar. All @entity0 achieved Bridwell grade 1 fusion from 2 years onward. @entity3 rate at 5 years was similar (RG=10%, NRG=0%, p=NS). Both groups showed significant postoperative improvement in all self-reported measures with no significant differences between the two groups at all follow-up points. Functional outcomes were equivalent. CONCLUSIONS: Intraoperative reduction does not improve outcomes in LGLS with @entity5 after MIS TLIF. Adequate decompression and solid fusion are likely the keys to good mid-term outcomes.

title: Intraoperative reduction does not result in better outcomes in low-grade lumbar spondylolisthesis with XXXX after minimally invasive transforaminal lumbar interbody fusion-a 5-year follow-up study.

answer: @entity5