abstract: UNASSIGNED: @entity4 ( @entity4 ) is a severe genetically @entity9 . @entity0 present with three principal phenotypes of motor symptoms: choreatic, @entity3 and mixed. The Q175 @entity1 model of disease offers an opportunity to investigate the cellular basis of the @entity3 form of @entity4 . At the age of 1year homozygote Q175 @entity1 exhibited the following signs of @entity5 : Reduced frequency of spontaneous movements on a precision balance at daytime (-55%), increased total time spent without movement in an open field (+42%), failures in the execution of unconditioned avoidance reactions (+32%), reduced ability for conditioned avoidance (-96%) and increased reaction times (+65%) in a shuttle box. Local field potential recordings revealed @entity7 in the striatum as a characteristic feature of @entity4 @entity1 at rest. There was no significant loss of @entity11 immunolabeled striatal projection neurons (SPNs) although the level of @entity11 immunoreactivity was lower in @entity4 . As a potential cause of @entity5 , @entity4 @entity1 revealed a strong reduction in striatal @entity8 -induced @entity2 release, accompanied by a decrease in the number of @entity6 hydroxylase-(TH)- and @entity12 -positive synaptic varicosities. The presynaptic TH fluorescence level was also reduced. Patch-clamp experiments were performed in slices from 1-year-old @entity1 to record unitary EPSCs (uEPSCs) of presumed cortical origin in the absence of G-protein-mediated modulation. In @entity4 @entity1 , the maximal amplitudes of uEPSCs amounted to 69% of the WT level which matches the loss of @entity10 +/SYP+ synaptic terminals in immunostained sections. These results identify impairment of cortico-striatal synaptic transmission and @entity2 release as a potential basis of @entity5 in @entity4 .

title: Pathological gamma oscillations, impaired @entity2 release, synapse loss and reduced dynamic range of unitary glutamatergic synaptic transmission in the striatum of hypokinetic Q175 Huntington XXXX .

answer: @entity1


abstract: OBJECTIVE: To assess the association between @entity3 ( @entity3 ) occurrence at the lumbar spine and Facet Joint (FJ) orientation, -tropism and - @entity2 . METHODS: Study group, 36 consecutive @entity0 with @entity3 and the same number of controls, with @entity1 without @entity3 were match paired for demographics and spine segment. Parameter assessment was by T2-weighted axial MRI scans. @entity3 diagnosis was confirmed histopathologically. Group comparison was by Student's t-test for continuous variables and X(2) for categorical variables. RESULTS: Nineteen female and 17 male @entity0 , aged between 45 and 85 years (mean 67.19  10.3 years) had a mean @entity3 size of 9.26  4.8mm occurring most frequently in the segment L4-L5 (75% n=25) and on the left side (61%). Mean FJ orientation of the study group was significantly more coronal compared to controls (left side 42   vs 36  , p<0.02*, 95% confidence interval: 0.9-11.5 and right side 43   vs 37  , p<0.02*, 95% confidence interval: 0.6-10.6 respectively). However, individual intersegmental analysis for study group @entity0 showed the @entity3 bearing side to be significantly more sagittally oriented 40    11.2   compared to 45    13.2   for the side without FJC (p<0.03*, 95% confidence interval: 8.1-1.7). 50% of the study group showed FJ asymmetry compared to 30% in controls, with a trend for FJ tropism (p<0.07). Severe (grade 3) FJ @entity2 was significantly more predominant in the study group 23/33 (p<0.001*) as compared to controls. CONCLUSIONS: Compared to a control group, @entity3 occurrence is associated with significant higher rates of @entity2 and coronally orientated FJ. At intersegment comparison within the same @entity0 cysts located in more sagittally orientated FJ and the asymmetric segments show a trend for FJ tropism.

title: Lumbar juxta-facet joint cysts in association with facet joint orientation, -tropism and - XXXX : A case-control study.

answer: @entity2


abstract: We have previously reported that fresh frozen plasma (FFP) may induce a rapid irreversible shock when repeatedly infused in @entity8 challenged with Gram-negative @entity2 . The aims of the present study were to elucidate the cardiovascular nature of the shock and determine the aetiologic role of @entity0 @entity1 factor (TNF), complement activation and @entity7 anaesthesia. Three groups of anaesthetized piglets were inoculated with a lethal dose of live @entity5 bacteria. Groups I (n = 8) and III (n = 8) were anaesthetized with @entity7 and group II (n = 8) with @entity9 . Animals in groups I and II received repeated infusions of FFP, whereas animals in group III received repeated infusions of 7% albumin. Six animals in group I and four animals in group II died during the first plasma infusion. Survival time was significantly longer in group II (P = 0.04) compared to group I. No animals in group III died during the albumin infusions, and no adverse effects were observed during the infusions. In group I the plasma induced shock was characterized by abruptly falling mean arterial pressure, cardiac index, systemic vascular resistance index and left ventricular contractility. Concomitant increases were recorded in left ventricular filling pressure and central venous pressure. Group II demonstrated a similar, but delayed response. Plasma infusion was associated with a significant increase in terminal complement complex (TCC) (P < 0.03 in group I, P < 0.05 in group II) and depletion of serum ionized @entity4 . We conclude that FFP may induce fatal @entity3 and @entity6 in severe @entity2 . Complement activation may be of aetiologic importance.

title: Fatal @entity3 and @entity6 associated with complement activation induced by plasma infusion in severe porcine XXXX .

answer: @entity2


abstract: We have previously reported that fresh frozen plasma (FFP) may induce a rapid irreversible shock when repeatedly infused in @entity8 challenged with Gram-negative @entity2 . The aims of the present study were to elucidate the cardiovascular nature of the shock and determine the aetiologic role of @entity0 @entity1 factor (TNF), complement activation and @entity7 anaesthesia. Three groups of anaesthetized piglets were inoculated with a lethal dose of live @entity5 bacteria. Groups I (n = 8) and III (n = 8) were anaesthetized with @entity7 and group II (n = 8) with @entity9 . Animals in groups I and II received repeated infusions of FFP, whereas animals in group III received repeated infusions of 7% albumin. Six animals in group I and four animals in group II died during the first plasma infusion. Survival time was significantly longer in group II (P = 0.04) compared to group I. No animals in group III died during the albumin infusions, and no adverse effects were observed during the infusions. In group I the plasma induced shock was characterized by abruptly falling mean arterial pressure, cardiac index, systemic vascular resistance index and left ventricular contractility. Concomitant increases were recorded in left ventricular filling pressure and central venous pressure. Group II demonstrated a similar, but delayed response. Plasma infusion was associated with a significant increase in terminal complement complex (TCC) (P < 0.03 in group I, P < 0.05 in group II) and depletion of serum ionized @entity4 . We conclude that FFP may induce fatal @entity3 and @entity6 in severe @entity2 . Complement activation may be of aetiologic importance.

title: Fatal @entity3 and XXXX associated with complement activation induced by plasma infusion in severe porcine @entity2 .

answer: @entity6


abstract: We have previously reported that fresh frozen plasma (FFP) may induce a rapid irreversible shock when repeatedly infused in @entity8 challenged with Gram-negative @entity2 . The aims of the present study were to elucidate the cardiovascular nature of the shock and determine the aetiologic role of @entity0 @entity1 factor (TNF), complement activation and @entity7 anaesthesia. Three groups of anaesthetized piglets were inoculated with a lethal dose of live @entity5 bacteria. Groups I (n = 8) and III (n = 8) were anaesthetized with @entity7 and group II (n = 8) with @entity9 . Animals in groups I and II received repeated infusions of FFP, whereas animals in group III received repeated infusions of 7% albumin. Six animals in group I and four animals in group II died during the first plasma infusion. Survival time was significantly longer in group II (P = 0.04) compared to group I. No animals in group III died during the albumin infusions, and no adverse effects were observed during the infusions. In group I the plasma induced shock was characterized by abruptly falling mean arterial pressure, cardiac index, systemic vascular resistance index and left ventricular contractility. Concomitant increases were recorded in left ventricular filling pressure and central venous pressure. Group II demonstrated a similar, but delayed response. Plasma infusion was associated with a significant increase in terminal complement complex (TCC) (P < 0.03 in group I, P < 0.05 in group II) and depletion of serum ionized @entity4 . We conclude that FFP may induce fatal @entity3 and @entity6 in severe @entity2 . Complement activation may be of aetiologic importance.

title: Fatal XXXX and @entity6 associated with complement activation induced by plasma infusion in severe porcine @entity2 .

answer: @entity3


abstract: OBJECTIVES: Randomized controlled trials (RCTs) in optimally cytoreduced @entity2 ( @entity2 ) @entity0 have demonstrated an impressive survival benefit of intraperitoneal (IP) @entity7 over intravenous (IV), but its use has been limited by significant @entity3 from @entity6 . The aim of this study was to compare the @entity3 and tolerability of IP @entity6 to IP @entity12 in @entity0 with optimally cytoreduced @entity2 . METHODS: Retrospective analysis of 141 @entity0 with @entity2 who underwent optimal surgical cytoreduction followed by IV @entity8 and IP @entity6 or IP @entity12 was performed. @entity3 of the two treatment regimens were compared. As a secondary outcome, @entity9 ( @entity9 ) and progression-free survival (PFS) probabilities were obtained using the Kaplan-Meier estimate; the log-rank test was used to compare survival curves. RESULTS: Of the 141 @entity0 , 77 (54.6%) received IP @entity6 and 64 (45.4%) received IP @entity12 . Eighty-six percent received at least 4cycles of IP chemotherapy. IP @entity6 was associated with significantly more grade 3 @entity4 and @entity5 (10.4% vs 1.6%, p=0.033), grade 3 @entity1 (7.8% vs 0%, p=0.013) and grade 2-3 @entity10 (22.1% vs 9.4%, p=0.042). No difference in PFS (p=0.602) or @entity9 (p=0.107) was found between the groups. CONCLUSION: IP chemotherapy had a high completion rate in both groups of @entity0 . IP @entity12 required a less resource intense protocol and was tolerated better than IP @entity6 with less @entity11 .

title: A comparison of the XXXX and tolerability of two intraperitoneal chemotherapy regimens for @entity2 .

answer: @entity3


abstract: OBJECTIVES: Randomized controlled trials (RCTs) in optimally cytoreduced @entity2 ( @entity2 ) @entity0 have demonstrated an impressive survival benefit of intraperitoneal (IP) @entity7 over intravenous (IV), but its use has been limited by significant @entity3 from @entity6 . The aim of this study was to compare the @entity3 and tolerability of IP @entity6 to IP @entity12 in @entity0 with optimally cytoreduced @entity2 . METHODS: Retrospective analysis of 141 @entity0 with @entity2 who underwent optimal surgical cytoreduction followed by IV @entity8 and IP @entity6 or IP @entity12 was performed. @entity3 of the two treatment regimens were compared. As a secondary outcome, @entity9 ( @entity9 ) and progression-free survival (PFS) probabilities were obtained using the Kaplan-Meier estimate; the log-rank test was used to compare survival curves. RESULTS: Of the 141 @entity0 , 77 (54.6%) received IP @entity6 and 64 (45.4%) received IP @entity12 . Eighty-six percent received at least 4cycles of IP chemotherapy. IP @entity6 was associated with significantly more grade 3 @entity4 and @entity5 (10.4% vs 1.6%, p=0.033), grade 3 @entity1 (7.8% vs 0%, p=0.013) and grade 2-3 @entity10 (22.1% vs 9.4%, p=0.042). No difference in PFS (p=0.602) or @entity9 (p=0.107) was found between the groups. CONCLUSION: IP chemotherapy had a high completion rate in both groups of @entity0 . IP @entity12 required a less resource intense protocol and was tolerated better than IP @entity6 with less @entity11 .

title: A comparison of the @entity3 and tolerability of two intraperitoneal chemotherapy regimens for XXXX .

answer: @entity2


abstract: OBJECTIVE: Stricture formation resulting in impedance of gastric emptying is a relatively common complication after gastric surgery that involves @entity1 creation or pyloroplasty. Treatment of the @entity3 with fluoroscopically guided @entity2 avoids further surgery. Accordingly, we report our experience with 32 dilating procedures in 24 consecutive @entity0 who had the postoperative complication of obstruction at a surgically created gastric outlet. MATERIALS AND METHODS: Out of our series of approximately 650 fluoroscopically guided balloon dilatations, 32 procedures were performed on 24 @entity0 with anastomotic strictures or pyloric narrowing after gastric surgery (vertical banded gastroplasty or gastric bypass surgery [n = 15], partial esophagectomy with esophagogastrostomy and pyloroplasty [n = 6], and partial gastrectomy with gastrojejunostomy [n = 3]). The group included 13 @entity0 and 11 @entity0 ranging from 32 to 79 years old (mean, 51 years). Diameters of the balloons chosen ranged from 10 to 20 mm, depending on the size of the surgically created @entity1 or pyloroplasty. Indications for @entity2 were clinical and radiographic evidence of @entity4 . The procedures were done between 13 days and 10 years (mean, 14 months) after gastric surgery. The result of each procedure was assessed by evaluating clinical outcome (relief or recurrence of symptoms) during the follow-up period of 2 days to 36 months (mean, 8 months) after the procedure. RESULTS: In 17 of the 24 @entity0 , the obstructive symptoms were treated successfully with a single dilatation procedure, and symptoms did not recur during follow-up ranging from 1 to 36 months (mean, 11 months). In the other seven @entity0 , the procedure was considered unsuccessful because the @entity0 experienced recurrent obstruction within 2 days to 13 weeks (mean, 3 weeks) after the initial procedure. In one of these, symptoms were relieved by a second procedure. Repeat dilatations in the other six @entity0 were unsuccessful, and all six eventually required surgical revision for definitive treatment. No complicating perforations were noted as a result of dilatation. CONCLUSION: Our experience shows that fluoroscopically guided @entity2 is a simple and safe technique for treating obstructive symptoms caused by strictures occurring after gastric surgery. In the majority of @entity0 , symptoms are relieved with a single @entity2 , eliminating the need for further surgery. However, @entity0 whose obstructive symptoms recur after the initial @entity2 procedure are less likely to benefit from further dilatations and usually require surgery.

title: Strictures after gastric surgery: treatment with fluoroscopically guided XXXX .

answer: @entity2


abstract: OBJECTIVE: The purposes of this study were to describe the characteristics of @entity2 of the oral cavity on unenhanced and contrast-enhanced T1-weighted spin-echo (SE) MR images and unenhanced T2-weighted @entity4 ( @entity4 ) MR images and to determine which sequences best delineate the margins and extent of the @entity1 . MATERIALS AND METHODS: Forty-four @entity0 with proved squamous cell @entity3 (tongue, 24; floor of mouth, seven; buccal mucosa, four; maxillary gingiva, two; and mandibular gingiva, seven) underwent unenhanced axial T2-weighted @entity4 MR imaging and unenhanced and enhanced axial and coronal T1-weighted SE MR imaging. The appearance, signal characteristics, and extent of the @entity1 were assessed, and the delineation of @entity1 margins with each sequence or combination of sequences was evaluated by use of a grading system ranging from 1 (poor) to 3 (excellent). Three @entity0 were excluded because of artifacts on the MR images caused by dental restorations. RESULTS: Tumors in all 41 @entity0 were depicted on unenhanced T1-weighted SE images, but in four @entity0 , @entity1 were not visible on T2-weighted @entity4 images. Except for @entity1 that invaded the maxillary gingiva, the @entity1 generally had homogeneous, low signal intensity on unenhanced T1-weighted images and nonhomogeneous, high signal intensity on T2-weighted @entity4 images. All @entity1 showed enhancement, 76% with a nonhomogeneous appearance. The delineation of @entity1 margins was excellent (grade 3) in 31 cases and fair (grade 2) in 10 cases. The highest rating was given for unenhanced T1-weighted images in 10 cases, for contrast-enhanced T1-weighted images in 10 cases, for the combination of both unenhanced and contrast-enhanced T1-weighted images in 18 cases, for the combination of unenhanced T1-weighted and T2-weighted @entity4 images in five cases, and for T2-weighted @entity4 images in one case. In three cases, the highest rating was given for both combinations of pulse sequences. CONCLUSION: An unenhanced T1-weighted sequence should be used as the basic pulse sequence for MR imaging of @entity1 of the oral cavity. When @entity1 margins are not clearly delineated with this sequence, T2-weighted @entity4 and contrast-enhanced T1-weighted sequences should be added. Although both of these sequences provide supplementary information, the contrast-enhanced T1-weighted sequence is more useful in delineating the margins and extent of @entity1 than is the T2-weighted @entity4 sequence.

title: Squamous cell carcinoma of the oral cavity: MR findings and value of T1-versus T2-weighted XXXX images.

answer: @entity4


abstract: To confirm the effect of 7-valent pneumococcal conjugate vaccine (PCV7), pneumococcal nasopharyngeal (NP) carriage was compared between vaccinated (3 + 1 doses PCV7) and non-vaccinated @entity0 . Vaccinated subjects were recruited from highly vaccinated regions (>=  60%), Seoul and Incheon whereas control subjects were recruited from Jeju Island where vaccination rates are low (< 15%). NP swabs were obtained from 400 @entity0 aged 18-59 months. Serotype and antibiotic susceptibility was analyzed. Pneumococcal carriage rate was 18.0% (36/200) and 31.5% (63/200) for the vaccinated and control group, respectively. Among those vaccinated, 41.7% (15/36) of the serotypes were vaccine-related type (VRT: 6A, 6C, 19A) with the most common serotype 6C. The next common type was non-typable/non-capsule 30.6% (11/36) followed by non- @entity3 16.7% (6/36) and @entity3 ( @entity3 ) serotypes were found in only 11.1% (4/36). In contrast, 52.4% (33/63) of the isolates in the control group were @entity3 . Resistance rates for @entity1 and @entity2 were lower in the vaccine group (vaccine vs control; @entity1 45.2% vs 71.4%, @entity2 74.2% vs 90.5%, P < 0.05). Multi-drug resistance was also lower in vaccinated subjects (vaccine vs control; 45.2% vs 69.8%, P < 0.05). PCV7 reduces carriage in @entity3 which leads to replacement of pneumococci by antibiotic susceptible VRT or non- @entity3 strains.

title: Nasopharyngeal pneumococcal carriage of XXXX attending day care centers in Korea: comparison between @entity0 immunized with 7-valent pneumococcal conjugate vaccine and non-immunized.

answer: @entity0


abstract: To confirm the effect of 7-valent pneumococcal conjugate vaccine (PCV7), pneumococcal nasopharyngeal (NP) carriage was compared between vaccinated (3 + 1 doses PCV7) and non-vaccinated @entity0 . Vaccinated subjects were recruited from highly vaccinated regions (>=  60%), Seoul and Incheon whereas control subjects were recruited from Jeju Island where vaccination rates are low (< 15%). NP swabs were obtained from 400 @entity0 aged 18-59 months. Serotype and antibiotic susceptibility was analyzed. Pneumococcal carriage rate was 18.0% (36/200) and 31.5% (63/200) for the vaccinated and control group, respectively. Among those vaccinated, 41.7% (15/36) of the serotypes were vaccine-related type (VRT: 6A, 6C, 19A) with the most common serotype 6C. The next common type was non-typable/non-capsule 30.6% (11/36) followed by non- @entity3 16.7% (6/36) and @entity3 ( @entity3 ) serotypes were found in only 11.1% (4/36). In contrast, 52.4% (33/63) of the isolates in the control group were @entity3 . Resistance rates for @entity1 and @entity2 were lower in the vaccine group (vaccine vs control; @entity1 45.2% vs 71.4%, @entity2 74.2% vs 90.5%, P < 0.05). Multi-drug resistance was also lower in vaccinated subjects (vaccine vs control; 45.2% vs 69.8%, P < 0.05). PCV7 reduces carriage in @entity3 which leads to replacement of pneumococci by antibiotic susceptible VRT or non- @entity3 strains.

title: Nasopharyngeal pneumococcal carriage of @entity0 attending day care centers in Korea: comparison between XXXX immunized with 7-valent pneumococcal conjugate vaccine and non-immunized.

answer: @entity0


abstract: INTRODUCTION: Washing the renal cavities using minipercutaneous surgery shaft is an ideal technical procedure for retrograde intrarenal surgery (RIRS) when lithiasic fragmentation is significant or if the anatomy of the renal cavities may obstruct the spontaneous elimination of fragments. MATERIALS AND METHODS: we performed 37 RIRS on 35 @entity0 with @entity1 (14 @entity0 , 21 @entity0 ) with a mean age of 56 (range 33-72) years, divided into two groups in accordance with the size of their @entity2 . Group A, 23 @entity0 with @entity4 <1.5 cm; Group B, 12 cases with @entity4 >1.5 cm. 28 @entity0 had a single kidney stone and 7 had multiple stones. APPROACH: Flexible uretrorenoscopy, 7.5 Fr (Flex-X(  , Karl Storz) by means of a ureteral access sheath. Holmium laser lithotripsy (Calculase  , Karl Storz) using 200 and 365 micrometer fibres. Fragment extraction with 1.7 Fr @entity3 baskets (N-gage, Cook). In cases of significant fragmented stone burden, the renal cavities were washed with low-pressure fluid irrigation using a ureteral access sheath, which was collected together with the stone fragments carried by the "mini-perc" sheath (Ultrax-x   18Fr, Cook; Rusch, 14 Fr) placed under radiologic and endoscopic control at the level of the calyx-papilla selected for fragment drainage. RESULTS: the mean diameter for group A was 9.13 (range 5-13) mm and 20.25 (range 16-28) mm for group B. The overall mean operating time was 81 (range 30-160) min. Group A required 66.43  35.18 min. and group B 107.5  46.73 min. (p=0.006). The rate of absence of stones immediately after surgery was 83.2%, 93.1% at 3 months (95.6% for A and 83.3% for B; p=0.217). In no case was ureteral stenosis observed as a result of the use of ureteral access sheaths. In 7 group B @entity0 (58.3%) with acute @entity4 and/or alteration in their pyelocaliceal anatomy, we performed active lavage of the renal cavities applying the aforementioned percutaneous technique. The mean post-surgery hospital stay was 2.1 (range 1-4) days. There were post-surgery complications (Clavien 1) in 7 @entity0 (20%). Two @entity0 required a second FURS. CONCLUSIONS: RIRS can be effective treatment for @entity1 >1.5 cm. Lavage of the renal cavities helps to eliminate stone fragments, reducing the possibility of retreatment.

title: [Retrograde intrarenal surgery (RIRS). Technical complement for cases of acute XXXX ].

answer: @entity4


abstract: OBJECTIVE: Our purpose was to determine the feasibility of ascertaining @entity1 for chromosomes X, Y, 18, and 16 by use of multiple-probe fluorescence in situ hybridization in blastomeres from preimplantation @entity0 embryos. STUDY DESIGN: A short fluorescence in situ hybridization procedure involving the simultaneous use of four deoxyribonucleic acid probes detected with red, green, blue, or a mixture of red and green fluorochromes was developed to determine numeric abnormalities of chromosomes X, Y, 18, and 16. Embryos underwent biopsy, and all or most cells were analyzed to distinguish true @entity1 from mosaicism and to assess technique variations within the same embryo (n = 64). RESULTS: The analysis of all the blastomeres of an embryo was achieved in 91% of the embryos. Successful analyses including biopsy, fixation, and fluorescence in situ hybridization were achieved in 87.8% of the blastomeres. Of the four chromosomes tested, numeric aberrations were found in 23% and 42% of normally and abnormally developing embryos, respectively, including @entity1 , @entity2 , haploidy, and mosaicism. When diploid embryos containing one or several tetraploid cells are counted as chromosomally abnormal, then 49% and 61% of normally and abnormally developing embryos, respectively, were chromosomally abnormal. @entity1 consisted of two monosomies for chromosome 16, one for chromosome 18, and a trisomy for chromosome 16. There was a tendency for @entity1 to increase with maternal age. CONCLUSIONS: Fluorescence in situ hybridization is a more efficient method than cytogenetic analysis to study specific aneuploidies at preimplantation stages of development in @entity0 embryos. In addition, the preimplantation genetic diagnosis of two blastomeres per eight-cell embryo may be sufficient to ensure successful analysis of @entity2 , haploidy, and specific aneuploidies without endangering the survival of the embryo. The technique can be easily modified to consider other chromosomes, including 13 and 21. Because most chromosomally abnormal embryos do not develop to term, the use of this technique may increase the delivery rate per embryo by allowing only transfer of embryos normal for the tested chromosomes. This technique would be most useful for older @entity0 undergoing in vitro fertilization, because @entity1 appears to increase with advancing maternal age.

title: Assessment of numeric abnormalities of X, Y, 18, and 16 chromosomes in preimplantation XXXX embryos before transfer.

answer: @entity0


abstract: Parent responses to the experiences of adolescents with @entity4 are deemed important. At the same time the best ways to conceptualize, measure, and intervene with these are unclear. The purpose of the present study was to develop a measure of parent responses based on the approach proposed in Acceptance and Commitment Therapy (ACT), an approach that focuses on @entity3 . A total of 183 adolescents attending a specialty treatment center for @entity4 , and adults attending with them, provided the data examined in this study. Standard measures of adolescent functioning and parent responses were obtained. In addition, the attending adults, who were mostly mothers, also completed a pool of items for an instrument called the Parent Psychological Flexibility Questionnaire (PPFQ). Preliminary analyses of these items showed an internal consistency of a=0.91. The total score for parent @entity3 was negatively correlated with protective and encouraging parent responses to @entity2 , as predicted. It was also positively correlated with adolescent acceptance of @entity2 and negatively correlated with measures of @entity2 on their social, emotional, family, and developmental functioning. Additional analyses showed that the PPFQ yields significant unique information about adolescent functioning independent of age and gender and beyond that provided by another well-established measure of parent responses. There is increasing evidence for the effectiveness of ACT in the treatment of a range of @entity1 in adults and young @entity0 and in training for @entity0 without identified "disorders." It seems potentially applicable for parent training in the context of adolescent @entity4 .

title: Role of @entity3 in parents of adolescents with XXXX : development of a measure and preliminary correlation analyses.

answer: @entity4


abstract: Parent responses to the experiences of adolescents with @entity4 are deemed important. At the same time the best ways to conceptualize, measure, and intervene with these are unclear. The purpose of the present study was to develop a measure of parent responses based on the approach proposed in Acceptance and Commitment Therapy (ACT), an approach that focuses on @entity3 . A total of 183 adolescents attending a specialty treatment center for @entity4 , and adults attending with them, provided the data examined in this study. Standard measures of adolescent functioning and parent responses were obtained. In addition, the attending adults, who were mostly mothers, also completed a pool of items for an instrument called the Parent Psychological Flexibility Questionnaire (PPFQ). Preliminary analyses of these items showed an internal consistency of a=0.91. The total score for parent @entity3 was negatively correlated with protective and encouraging parent responses to @entity2 , as predicted. It was also positively correlated with adolescent acceptance of @entity2 and negatively correlated with measures of @entity2 on their social, emotional, family, and developmental functioning. Additional analyses showed that the PPFQ yields significant unique information about adolescent functioning independent of age and gender and beyond that provided by another well-established measure of parent responses. There is increasing evidence for the effectiveness of ACT in the treatment of a range of @entity1 in adults and young @entity0 and in training for @entity0 without identified "disorders." It seems potentially applicable for parent training in the context of adolescent @entity4 .

title: Role of XXXX in parents of adolescents with @entity4 : development of a measure and preliminary correlation analyses.

answer: @entity3


abstract: Since @entity7 has only recently been recognized as a morphologic entity, its pathobiology has not been studied. Fourteen examples occurring in seven females and six males, ages 9 to 82 years (mean 29 years), were examined; one was associated with type 2 @entity10 . Of these cases, seven (50%) were spinal-intradural (six lumbar, one thoracic), three (21%) arose in the posterior fossa (cerebellopontine angle), three (21%) were supratentorial, and one (7%) was centered upon the foramen magnum. In one case (8%), two @entity2 were considered to be independent primaries. One @entity2 (8%) appeared to show no dural attachment. Thirteen @entity2 were subject to complete study. All were composed of sheets of clear, glycogen-rich, polygonal cells forming only a few vague whorls. @entity11 , both stromal and perivascular, was often extensive. Mitoses were rare in @entity2 . Immunohistochemistry showed vimentin and epithelial membrane antigen staining to be reactive in 100%. Stains for @entity9 protein and CAM 5.2 were negative. @entity6 and @entity4 receptor staining was observed in 77% and 0%, respectively. Ultrastructural study showed abundant cytoplasmic glycogen, a few cytoplasmic lumina, intermediate filaments, interdigitation of cell membranes, and desmosomal junctions. The means, medians, and ranges of @entity5 ( @entity5 ) and @entity8 antigen labeling indices for nonrecurring and recurring @entity2 were 10.4%, 8.8%, 0.8-23.4% and 11%, 1.4%, 0.1-50.3%, as compared with 7.4%, 6.7%, 2.9-17.2% and 13.3%, 13.4%, 3.3-25.7%, respectively. Twelve successful DNA ploidy studies showed that 11 @entity2 (85%) were diploid and one was tetraploid; percentage S-phase determinations varied from 4 to 9% (mean 6.0%). Recurrence was noted in eight @entity0 (61%) (five of whom had multiple recurrences); there was local discontinuous spread in two cases (15%) and widespread cranial to spinal @entity1 in one case (8%). Three @entity0 (23%) are dead of disease. In summary, @entity7 are morphologically unique, show no sex predilection, affect primarily the lumbar region and cerebellopontine angle, and despite their benign appearance, may be @entity3 , particularly intracranial examples. No close association was noted between recurrence or clinical outcome and such factors as mitotic activity, @entity5 proliferation indices, percent S-phase determination, or DNA ploidy status. In contrast, @entity8 proliferation indices were appreciably higher among recurring @entity2 .

title: XXXX . A clinicopathologic study of a potentially aggressive variant of @entity7 .

answer: @entity7


abstract: Since @entity7 has only recently been recognized as a morphologic entity, its pathobiology has not been studied. Fourteen examples occurring in seven females and six males, ages 9 to 82 years (mean 29 years), were examined; one was associated with type 2 @entity10 . Of these cases, seven (50%) were spinal-intradural (six lumbar, one thoracic), three (21%) arose in the posterior fossa (cerebellopontine angle), three (21%) were supratentorial, and one (7%) was centered upon the foramen magnum. In one case (8%), two @entity2 were considered to be independent primaries. One @entity2 (8%) appeared to show no dural attachment. Thirteen @entity2 were subject to complete study. All were composed of sheets of clear, glycogen-rich, polygonal cells forming only a few vague whorls. @entity11 , both stromal and perivascular, was often extensive. Mitoses were rare in @entity2 . Immunohistochemistry showed vimentin and epithelial membrane antigen staining to be reactive in 100%. Stains for @entity9 protein and CAM 5.2 were negative. @entity6 and @entity4 receptor staining was observed in 77% and 0%, respectively. Ultrastructural study showed abundant cytoplasmic glycogen, a few cytoplasmic lumina, intermediate filaments, interdigitation of cell membranes, and desmosomal junctions. The means, medians, and ranges of @entity5 ( @entity5 ) and @entity8 antigen labeling indices for nonrecurring and recurring @entity2 were 10.4%, 8.8%, 0.8-23.4% and 11%, 1.4%, 0.1-50.3%, as compared with 7.4%, 6.7%, 2.9-17.2% and 13.3%, 13.4%, 3.3-25.7%, respectively. Twelve successful DNA ploidy studies showed that 11 @entity2 (85%) were diploid and one was tetraploid; percentage S-phase determinations varied from 4 to 9% (mean 6.0%). Recurrence was noted in eight @entity0 (61%) (five of whom had multiple recurrences); there was local discontinuous spread in two cases (15%) and widespread cranial to spinal @entity1 in one case (8%). Three @entity0 (23%) are dead of disease. In summary, @entity7 are morphologically unique, show no sex predilection, affect primarily the lumbar region and cerebellopontine angle, and despite their benign appearance, may be @entity3 , particularly intracranial examples. No close association was noted between recurrence or clinical outcome and such factors as mitotic activity, @entity5 proliferation indices, percent S-phase determination, or DNA ploidy status. In contrast, @entity8 proliferation indices were appreciably higher among recurring @entity2 .

title: @entity7 . A clinicopathologic study of a potentially aggressive variant of XXXX .

answer: @entity7


abstract: OBJECTIVES: The aim of the article is to critically appraise and synthesize available evidence regarding the efficacy and regimen-related @entity2 (RRT) of @entity6 plus @entity8 (BuFlu) compared to @entity6 plus @entity3 (BuCy) as a conditioning regimen, prior to allogeneic hematopoietic stem cell transplantation (HSCT) in @entity0 with @entity5 . METHODS: A meta-analysis was attempted on clinical controlled trials (CCTs), randomized or non-randomized controlled trials (RCTs or non-RCTs), comparing BuCy with BuFlu. We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by @entity4 ( @entity4 ) and event-free survival (EFS), @entity7 ( @entity7 ). @entity1 (extensive) and other @entity2 were secondary endpoints. A relative risk or risk ratio (RR) and 95% confidence interval (CI) was calculated for each outcome in the meta-analysis. RESULTS: Nine clinical controlled trials were included, of which 4 tries were RCTs involving 584 @entity0 and the other 5 were non-RCTs involving 571 @entity0 . The cumulative incidences of @entity4 , EFS, @entity7 ( @entity7 ) were not significantly different between the two regimens. The non-relapse mortality was higher in BuCy but non-significant increment (RR=1.48, 95% CI: [0.97-2.26]). Liver related @entity2 was significantly higher with BuCy compared to BuFlu (RR=1.90, 95% CI: [1.00-3.61]). CONCLUSION: Liver related @entity2 is significantly lesser with BuFlu, but BuFlu regimen has no significant benefits compared with BuCy in @entity4 , EFS, @entity7 . For all this, the weight of evidence favors BuFlu over BuCy as a first choice-conditioning regimen for @entity0 with @entity5 , especially for @entity0 who have poor liver function.

title: XXXX plus @entity8 compared with @entity6 plus @entity3 as a conditioning regimen prior to hematopoietic stem cell transplantation in @entity0 with @entity5 : a meta-analysis.

answer: @entity6


abstract: OBJECTIVES: The aim of the article is to critically appraise and synthesize available evidence regarding the efficacy and regimen-related @entity2 (RRT) of @entity6 plus @entity8 (BuFlu) compared to @entity6 plus @entity3 (BuCy) as a conditioning regimen, prior to allogeneic hematopoietic stem cell transplantation (HSCT) in @entity0 with @entity5 . METHODS: A meta-analysis was attempted on clinical controlled trials (CCTs), randomized or non-randomized controlled trials (RCTs or non-RCTs), comparing BuCy with BuFlu. We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by @entity4 ( @entity4 ) and event-free survival (EFS), @entity7 ( @entity7 ). @entity1 (extensive) and other @entity2 were secondary endpoints. A relative risk or risk ratio (RR) and 95% confidence interval (CI) was calculated for each outcome in the meta-analysis. RESULTS: Nine clinical controlled trials were included, of which 4 tries were RCTs involving 584 @entity0 and the other 5 were non-RCTs involving 571 @entity0 . The cumulative incidences of @entity4 , EFS, @entity7 ( @entity7 ) were not significantly different between the two regimens. The non-relapse mortality was higher in BuCy but non-significant increment (RR=1.48, 95% CI: [0.97-2.26]). Liver related @entity2 was significantly higher with BuCy compared to BuFlu (RR=1.90, 95% CI: [1.00-3.61]). CONCLUSION: Liver related @entity2 is significantly lesser with BuFlu, but BuFlu regimen has no significant benefits compared with BuCy in @entity4 , EFS, @entity7 . For all this, the weight of evidence favors BuFlu over BuCy as a first choice-conditioning regimen for @entity0 with @entity5 , especially for @entity0 who have poor liver function.

title: @entity6 plus @entity8 compared with XXXX plus @entity3 as a conditioning regimen prior to hematopoietic stem cell transplantation in @entity0 with @entity5 : a meta-analysis.

answer: @entity6


abstract: OBJECTIVES: The aim of the article is to critically appraise and synthesize available evidence regarding the efficacy and regimen-related @entity2 (RRT) of @entity6 plus @entity8 (BuFlu) compared to @entity6 plus @entity3 (BuCy) as a conditioning regimen, prior to allogeneic hematopoietic stem cell transplantation (HSCT) in @entity0 with @entity5 . METHODS: A meta-analysis was attempted on clinical controlled trials (CCTs), randomized or non-randomized controlled trials (RCTs or non-RCTs), comparing BuCy with BuFlu. We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by @entity4 ( @entity4 ) and event-free survival (EFS), @entity7 ( @entity7 ). @entity1 (extensive) and other @entity2 were secondary endpoints. A relative risk or risk ratio (RR) and 95% confidence interval (CI) was calculated for each outcome in the meta-analysis. RESULTS: Nine clinical controlled trials were included, of which 4 tries were RCTs involving 584 @entity0 and the other 5 were non-RCTs involving 571 @entity0 . The cumulative incidences of @entity4 , EFS, @entity7 ( @entity7 ) were not significantly different between the two regimens. The non-relapse mortality was higher in BuCy but non-significant increment (RR=1.48, 95% CI: [0.97-2.26]). Liver related @entity2 was significantly higher with BuCy compared to BuFlu (RR=1.90, 95% CI: [1.00-3.61]). CONCLUSION: Liver related @entity2 is significantly lesser with BuFlu, but BuFlu regimen has no significant benefits compared with BuCy in @entity4 , EFS, @entity7 . For all this, the weight of evidence favors BuFlu over BuCy as a first choice-conditioning regimen for @entity0 with @entity5 , especially for @entity0 who have poor liver function.

title: @entity6 plus @entity8 compared with @entity6 plus XXXX as a conditioning regimen prior to hematopoietic stem cell transplantation in @entity0 with @entity5 : a meta-analysis.

answer: @entity3


abstract: OBJECTIVES: The aim of the article is to critically appraise and synthesize available evidence regarding the efficacy and regimen-related @entity2 (RRT) of @entity6 plus @entity8 (BuFlu) compared to @entity6 plus @entity3 (BuCy) as a conditioning regimen, prior to allogeneic hematopoietic stem cell transplantation (HSCT) in @entity0 with @entity5 . METHODS: A meta-analysis was attempted on clinical controlled trials (CCTs), randomized or non-randomized controlled trials (RCTs or non-RCTs), comparing BuCy with BuFlu. We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by @entity4 ( @entity4 ) and event-free survival (EFS), @entity7 ( @entity7 ). @entity1 (extensive) and other @entity2 were secondary endpoints. A relative risk or risk ratio (RR) and 95% confidence interval (CI) was calculated for each outcome in the meta-analysis. RESULTS: Nine clinical controlled trials were included, of which 4 tries were RCTs involving 584 @entity0 and the other 5 were non-RCTs involving 571 @entity0 . The cumulative incidences of @entity4 , EFS, @entity7 ( @entity7 ) were not significantly different between the two regimens. The non-relapse mortality was higher in BuCy but non-significant increment (RR=1.48, 95% CI: [0.97-2.26]). Liver related @entity2 was significantly higher with BuCy compared to BuFlu (RR=1.90, 95% CI: [1.00-3.61]). CONCLUSION: Liver related @entity2 is significantly lesser with BuFlu, but BuFlu regimen has no significant benefits compared with BuCy in @entity4 , EFS, @entity7 . For all this, the weight of evidence favors BuFlu over BuCy as a first choice-conditioning regimen for @entity0 with @entity5 , especially for @entity0 who have poor liver function.

title: @entity6 plus XXXX compared with @entity6 plus @entity3 as a conditioning regimen prior to hematopoietic stem cell transplantation in @entity0 with @entity5 : a meta-analysis.

answer: @entity8


abstract: OBJECTIVES: The aim of the article is to critically appraise and synthesize available evidence regarding the efficacy and regimen-related @entity2 (RRT) of @entity6 plus @entity8 (BuFlu) compared to @entity6 plus @entity3 (BuCy) as a conditioning regimen, prior to allogeneic hematopoietic stem cell transplantation (HSCT) in @entity0 with @entity5 . METHODS: A meta-analysis was attempted on clinical controlled trials (CCTs), randomized or non-randomized controlled trials (RCTs or non-RCTs), comparing BuCy with BuFlu. We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by @entity4 ( @entity4 ) and event-free survival (EFS), @entity7 ( @entity7 ). @entity1 (extensive) and other @entity2 were secondary endpoints. A relative risk or risk ratio (RR) and 95% confidence interval (CI) was calculated for each outcome in the meta-analysis. RESULTS: Nine clinical controlled trials were included, of which 4 tries were RCTs involving 584 @entity0 and the other 5 were non-RCTs involving 571 @entity0 . The cumulative incidences of @entity4 , EFS, @entity7 ( @entity7 ) were not significantly different between the two regimens. The non-relapse mortality was higher in BuCy but non-significant increment (RR=1.48, 95% CI: [0.97-2.26]). Liver related @entity2 was significantly higher with BuCy compared to BuFlu (RR=1.90, 95% CI: [1.00-3.61]). CONCLUSION: Liver related @entity2 is significantly lesser with BuFlu, but BuFlu regimen has no significant benefits compared with BuCy in @entity4 , EFS, @entity7 . For all this, the weight of evidence favors BuFlu over BuCy as a first choice-conditioning regimen for @entity0 with @entity5 , especially for @entity0 who have poor liver function.

title: @entity6 plus @entity8 compared with @entity6 plus @entity3 as a conditioning regimen prior to hematopoietic stem cell transplantation in @entity0 with XXXX : a meta-analysis.

answer: @entity5


abstract: OBJECTIVES: The aim of the article is to critically appraise and synthesize available evidence regarding the efficacy and regimen-related @entity2 (RRT) of @entity6 plus @entity8 (BuFlu) compared to @entity6 plus @entity3 (BuCy) as a conditioning regimen, prior to allogeneic hematopoietic stem cell transplantation (HSCT) in @entity0 with @entity5 . METHODS: A meta-analysis was attempted on clinical controlled trials (CCTs), randomized or non-randomized controlled trials (RCTs or non-RCTs), comparing BuCy with BuFlu. We did a systematic search of the indexed medical literature using appropriate keywords to identify potentially relevant articles. The primary outcome of interest was efficacy measured by @entity4 ( @entity4 ) and event-free survival (EFS), @entity7 ( @entity7 ). @entity1 (extensive) and other @entity2 were secondary endpoints. A relative risk or risk ratio (RR) and 95% confidence interval (CI) was calculated for each outcome in the meta-analysis. RESULTS: Nine clinical controlled trials were included, of which 4 tries were RCTs involving 584 @entity0 and the other 5 were non-RCTs involving 571 @entity0 . The cumulative incidences of @entity4 , EFS, @entity7 ( @entity7 ) were not significantly different between the two regimens. The non-relapse mortality was higher in BuCy but non-significant increment (RR=1.48, 95% CI: [0.97-2.26]). Liver related @entity2 was significantly higher with BuCy compared to BuFlu (RR=1.90, 95% CI: [1.00-3.61]). CONCLUSION: Liver related @entity2 is significantly lesser with BuFlu, but BuFlu regimen has no significant benefits compared with BuCy in @entity4 , EFS, @entity7 . For all this, the weight of evidence favors BuFlu over BuCy as a first choice-conditioning regimen for @entity0 with @entity5 , especially for @entity0 who have poor liver function.

title: @entity6 plus @entity8 compared with @entity6 plus @entity3 as a conditioning regimen prior to hematopoietic stem cell transplantation in XXXX with @entity5 : a meta-analysis.

answer: @entity0


abstract: OBJECTIVE: This study is to investigate the compensatory intracranial venous pathways in @entity4 ( @entity4 ) @entity0 by virtual reality technology. METHODS: A total of 48 @entity4 @entity0 ( @entity1 group) and 20 @entity0 with @entity7 and hemifacial @entity6 but without @entity3 (control group) were enrolled. All @entity0 underwent 3D CE-MRV examination. The 3D reconstructed images by virtual reality technology were used for assessment of diameter and number of intracranial veins, @entity1 location, @entity2 degree and collateral circulation formation. RESULTS: Diameter of bridging veins in posterior 1/3 superior sagittal sinus (SSS) in @entity1 group was significantly smaller than that of the control group (P < 0.05). For @entity1 located in mid 1/3 SSS, diameter of bridging veins and vein of Labb   (VL) in posterior 1/3 SSS decreased significantly (P < 0.05). For @entity1 located in posterior 1/3 SSS, bridging vein number and @entity5 ( @entity5 ) diameter significantly decreased while superficial Sylvian vein ( @entity8 ) diameter increased significantly (P < 0.05). Compared with @entity1 in posterior 1/3 SSS subgroup, number of bridging veins in the @entity1 in mid 1/3 SSS subgroup increased significantly (P < 0.05). Compared with control group, only the bridging vein number in anterior 1/3 SSS segment in invasion Type 3-4 @entity1 subgroup decreased significantly (P < 0.05). Diameter of @entity5 and bridging veins in posterior 1/3 SSS segment in sinus invasion Type 5-6 @entity1 subgroup decreased significantly (P < 0.05). Compared with control group, only the diameter of VL and @entity5 of collateral circulation Grade 1 @entity1 subgroup decreased significantly (P < 0.05) while in Grade 3 @entity1 subgroup, @entity5 diameter decreased and @entity8 diameter increased significantly (P < 0.05). CONCLUSIONS: The intracranial blood flow is mainly drained through @entity8 drainage after SSS occlusion by @entity4 .

title: Effects of XXXX on intracranial venous circulation assessed by the virtual reality technology.

answer: @entity4


abstract: @entity2 ( @entity2 ) after resection for @entity1 accelerates morbidity and mortality rates, extends hospital stay, and increases treatment costs, particularly when requiring laparotomy. The role of a protective diverting stoma (DS) in avoiding leakage has repeatedly been discussed, but prospective randomized studies on this subject are rare and their results contradictory. The MEDLINE database was searched for studies of @entity2 requiring laparotomy and of the associated rate of protective DSs in initial anterior resection (AR) to review these studies systematically. The collected data were used to determine the average rate of @entity2 requiring laparotomy after @entity0 surgery in the DS group compared with that in the non-DS group. A total of 930 abstracts were retrieved from MEDLINE; 15 articles on AR and 22 on low/ultralow AR (LAR) were included in the review and analysis. The overall rate of @entity2 requiring laparotomy was 6.57% (813/12, 376) in the AR studies and 4.13% (157/3, 802) in the LAR studies. In the AR studies, the pooled @entity2 rate in the DS group was higher than that in the non-DS group (12.30% vs. 9.16%, P < 0.001). However, the pooled rate of @entity2 requiring laparotomy in the DS group was lower than that in the non-DS group (3.69% vs. 7.42%, P < 0.001). In the LAR studies, the pooled @entity2 rate in the DS group was lower than that in the non-DS group (7.74% vs. 9.64%, P = 0.045). The pooled rate of @entity2 requiring laparotomy in the DS group was also lower than that in the non-DS group (2.67% vs. 5.21%, P < 0.001). By contrast, the pooled rate of definitive stomas and mortality caused by @entity2 did not have any statistical difference between the DS and non-DS groups in both AR studies (definitive stomas: 0% vs. 0.65%; mortality: 0.95% vs. 1.19%) and LAR studies (definitive stomas: 1.03% vs. 1.01%; mortality: 0.35% vs. 0.36%). Protective DSs significantly decrease the rate of @entity2 in LAR. @entity2 requiring surgical correction was significantly reduced in the DS group in both AR and LAR studies. Protective DSs did not affect the definitive stomas and mortality rate; this lack of an effect warrants further high-quality clinical trials.

title: Diverting stoma with anterior resection for XXXX : does it reduce overall anastomotic leakage and leaks requiring laparotomy?

answer: @entity0


abstract: OBJECTIVE: Uterine artery embolization (UAE) has been commonly used for uterine @entity1 with satisfactory effects, but the @entity0 during and following the procedure with an occurrence rate in 100%. The aim of this study was to observe the effects of intermittent injection with super-low pressure on @entity0 control during the UAE for uterine @entity1 . METHODS: 67 subjects were divided into 2 groups with 47 in-group A and 20 in group B. A underwent UAE with the intermittent injection at super-low pressure, while B underwent routine UAE. @entity0 was assessed according to WHO analgesic ladder. Meanwhile, all were scored with the visual analogue scale (VAS). RESULTS: The numbers of first, second and third step analgesic user in Group A were 21, 18 and 6, respectively, with 2 non-analgesic users, while in Group B were 4, 6 and 10, respectively without non-analgesic user (chi-square = 7.043, P = 0.008). VAS showed @entity0 control in 23 cases, satisfactory in 18 and poor in 6 in Group A, while in Group B, were 4, 8 and 8, respectively (chi-square = 7.329, P = 0.007). Mean follow-up was 16.5 months (range, 6-32 months). The abnormal menstruation was improved and the ultrasound examination 6 months later demonstrated a significant decrease in the diameter of @entity1 (from 6.65    2.40 cm to 5.22    1.86 cm, t = 3.186, P = 0.002). CONCLUSION: The application of intermittent injection with super-low pressure during UAE can decrease and possibly eliminate post-operative @entity0 . But the procedure time was increased.

title: Effects of the intermittent injection with super-low pressure on the postoperative pain control during the uterine artery embolization for uterine XXXX .

answer: @entity1


abstract: Three-dimensional structural model of @entity4 hydrolase (PchEHA) from Phanerochaete chrysosporium was constructed based on X-ray structure of @entity2 AD1 sEH using SWISS-MODEL server. Conserved residues constituting the active site cavity were identified, of which the functional roles of 14 residues were determined by site-directed mutagenesis. In catalytic triad, @entity0 105 and His308 play a leading role in alkylation and hydrolysis steps, respectively. Distance between @entity0 105 and @entity4 ring of substrate may determine the regiospecificity in the substrate docking model. @entity0 277 located at the entrance of substrate tunnel is concerned with catalysis but not essential. @entity5 had the highest activity and lower enantioselectivity among 14 mutants, suggesting @entity0 307 may be involved in choice of substrate configuration. @entity6 and @entity7 almost exhibited no activity, indicating that they are essential to bind substrate and facilitate opening of @entity4 ring. Besides, His35- @entity3 36- @entity1 37-Pro38, Trp106 and Trp309 surrounding @entity0 105, may coordinate the integration of active site cavity and influence substrate binding. Especially, W106I reversed the enantioselectivity, perhaps due to more deteriorative impact on the preferred @entity8 . @entity3 65 and Gly67 occurring at b-turns and Gly36 are vital in holding protein conformation. Conclusively, single conserved residue around the active sites has an important impact on catalytic properties.

title: Homology modelling and site-directed mutagenesis studies of the XXXX hydrolase from Phanerochaete chrysosporium.

answer: @entity4


abstract: OBJECTIVE: To demonstrate feasibility of performing quantitative MRI measurements in an immuno-competent @entity2 model of @entity5 by comparing in vivo anatomic and quantitative imaging measurements to @entity1 dissemination observations and histologic assays at necropsy. Meterials and methods: @entity2 ductal pancreatic @entity4 @entity2 cell line and Lewis @entity2 were used for these studies. 10(8) @entity2 cells were injected subcutaneously into the right flank of donor @entity2 . Donor @entity1 reaching 10 mm were excised, and 1 mm(3) @entity1 fragments were implanted within recipient @entity2 pancreas during mini-laparotomy. T1-weighted, T2-weighted, diffusion-weighted, and dynamic contrast-enhanced (DCE) MRI were performed using a Bruker 7.0T ClinScan. After MRI, all animals underwent autopsy. @entity1 size was measured, and dissemination score was used to assess local invasion and distant @entity0 . @entity1 and all sites of @entity0 were harvested and fixed for H_E, Masson's trichrome, and rat anti- @entity6 staining. Trichrome slides were scanned and digitized for measurement of fibrotic tissue areas. Anti- @entity6 slides were used for microvessel density (MVD) measurements. RESULTS: @entity1 , local invasion, and distant @entity0 were confirmed for all @entity2 . No significant differences were found between in vivo MRI measurements (48.7    5.3 mm) and ex vivo caliper measurements (43.6    3.6 mm) of @entity1 sizes (p > .05). Spleen, liver, diaphragm, peritoneum, and abdominal wall @entity0 were observed on MRI but smaller lung, mediastinum, omen, and mesentery @entity0 were only observed at necropsy. Contrast uptake observed during DCE measurements was significantly greater in both primary and metastatic @entity1 tissues compared to skeletal muscle and normal liver tissues. Both primary and @entity0 were hyper-intense in T2-weighted images and hypo-intense in T1-weighted images, but no differences were found between quantitative T2 measurements in @entity1 and that in @entity0 . Similarly, quantitative ADC measurements were similar for both @entity1 and liver @entity0 (1.13    0.3 * 10(-3) and 1.24    0.4 * 10(-3) mm(2)/s, respectively). Histologic @entity3 and MVD measurements were similar in @entity1 and @entity0 . CONCLUSIONS: Anatomic and quantitative functional MRI measurements are feasible in orthotropic DSL @entity2 model and will permit non-invasive monitoring of @entity1 responses during longitudinal studies intended to develop new interventional therapies for primary and metastatic disease.

title: Quantitative functional MRI in a clinical orthotopic model of XXXX in immunocompetent Lewis @entity2 .

answer: @entity5


abstract: OBJECTIVE: To demonstrate feasibility of performing quantitative MRI measurements in an immuno-competent @entity2 model of @entity5 by comparing in vivo anatomic and quantitative imaging measurements to @entity1 dissemination observations and histologic assays at necropsy. Meterials and methods: @entity2 ductal pancreatic @entity4 @entity2 cell line and Lewis @entity2 were used for these studies. 10(8) @entity2 cells were injected subcutaneously into the right flank of donor @entity2 . Donor @entity1 reaching 10 mm were excised, and 1 mm(3) @entity1 fragments were implanted within recipient @entity2 pancreas during mini-laparotomy. T1-weighted, T2-weighted, diffusion-weighted, and dynamic contrast-enhanced (DCE) MRI were performed using a Bruker 7.0T ClinScan. After MRI, all animals underwent autopsy. @entity1 size was measured, and dissemination score was used to assess local invasion and distant @entity0 . @entity1 and all sites of @entity0 were harvested and fixed for H_E, Masson's trichrome, and rat anti- @entity6 staining. Trichrome slides were scanned and digitized for measurement of fibrotic tissue areas. Anti- @entity6 slides were used for microvessel density (MVD) measurements. RESULTS: @entity1 , local invasion, and distant @entity0 were confirmed for all @entity2 . No significant differences were found between in vivo MRI measurements (48.7    5.3 mm) and ex vivo caliper measurements (43.6    3.6 mm) of @entity1 sizes (p > .05). Spleen, liver, diaphragm, peritoneum, and abdominal wall @entity0 were observed on MRI but smaller lung, mediastinum, omen, and mesentery @entity0 were only observed at necropsy. Contrast uptake observed during DCE measurements was significantly greater in both primary and metastatic @entity1 tissues compared to skeletal muscle and normal liver tissues. Both primary and @entity0 were hyper-intense in T2-weighted images and hypo-intense in T1-weighted images, but no differences were found between quantitative T2 measurements in @entity1 and that in @entity0 . Similarly, quantitative ADC measurements were similar for both @entity1 and liver @entity0 (1.13    0.3 * 10(-3) and 1.24    0.4 * 10(-3) mm(2)/s, respectively). Histologic @entity3 and MVD measurements were similar in @entity1 and @entity0 . CONCLUSIONS: Anatomic and quantitative functional MRI measurements are feasible in orthotropic DSL @entity2 model and will permit non-invasive monitoring of @entity1 responses during longitudinal studies intended to develop new interventional therapies for primary and metastatic disease.

title: Quantitative functional MRI in a clinical orthotopic model of @entity5 in immunocompetent Lewis XXXX .

answer: @entity2


abstract: A retrospective analysis was made about the results achieved in 64 @entity0 after combined surgical and radiotherapeutic treatment. The @entity2 areas were irradiated by fast electrons or @entity3 60 with 50 to 55 Gy, the lymph nodes received doses of 45 to 55 Gy. @entity2 control was achieved in 27 out of 28 @entity0 irradiated immediately after surgery (96%). In case of demonstrated lymph node invasion, local control was achieved in 14 out of 19 cases (74%). The median survival was 9.6 years for @entity0 in stage @entity5 .5 years for @entity0 in stage T1-4, N+, M0. The first two years following to therapy were decisive for the prognosis. Among those of our @entity0 who developed recurrences during this period, not one could be cured in the long run. Two years after the end of therapy, the survival probability of @entity0 without lymph node @entity1 becomes comparable to the survival curve of normal male population of the same age. In the treatment of @entity4 , a gradual proceeding depending on the stage is recommended for the combination of surgery and radiotherapy. In case of lymph node @entity1 , the application of adjuvant chemotherapy should be taken into consideration.

title: [Treatment results of surgical and radiologic therapy of XXXX ].

answer: @entity2


abstract: UNASSIGNED: Skull-base @entity7 is a @entity5 affecting the medulla of the temporal, sphenoid, and occipital bones. In general, it occurs due to external ear canal @entity4 caused by @entity1 . Skull-base @entity7 usually affects elderly @entity2 @entity0 . The @entity0 , a 58-year-old @entity0 , was referred for evaluation and management of the left jaw. Clinical examination of the @entity0 revealed @entity3 to the left. The maximum @entity6 was measured to about 27  mm. Panoramic, CT, and CBCT revealed bone resorption patterns in the left condyle. Through control of @entity2 , continued pharmacological treatment, arthrocentesis, and occlusal stabilization appliance therapy were carried out. The extent of @entity6 was increased to 45  mm, and @entity3 in the left jaw joint was alleviated. This was a case wherein complications caused by failure to control @entity2 induced skull-base @entity7 . There is a need for continued discussion about the advantages and disadvantages of arthrocentesis with lavage for @entity0 with skull-base @entity7 and other treatment options.

title: Temporomandibular joint disorder from skull-base XXXX : a case report.

answer: @entity7


abstract: The study aimed to analyze the lifestyles, weight control behavior, dietary habits, and @entity1 of female university students. The subjects were 532 students from 8 universities located in 4 provinces in Korea. According to percent ideal body weight, 33 (6.4%), 181 (34.0%), 283 (53.2%), 22 (4.1%) and 13 (2.5%) were severely underweight, underweight, normal, overweight and @entity0 , respectively, based on self-reported height and weight. As much as 64.1% and only 2.4%, respectively, overestimated and underestimated their body weight status. Six overweight subjects were excluded from overestimation group for the purpose of this study, resulting in overestimation group consisting of only underweight and normal weight subjects. Compared to those from the normal perception group, significantly more subjects from the overestimation group were currently smoking (P = 0.017) and drank more often than once a week (P = 0.015), without any significant differences in dietary habits. Despite similar BMIs, subjects who overestimated their own weight statuses had significantly higher weight dissatisfaction (P = 0.000), @entity0 stress (P = 0.000), obsession to lose weight (P = 0.007) and @entity1 (P = 0.018). Also, more of them wanted to lose weight (P = 0.000), checked their body weights more often than once a week (P = 0.025) and had dieting experiences using 'reducing meal size' (P = 0.012), 'reducing snacks' (P = 0.042) and 'taking prescribed pills' (P = 0.032), and presented 'for a wider range of clothes selection' as the reason for weight loss (P = 0.039), although none was actually overweight or @entity0 . Unlike the case with overestimating one's own weight, being overweight was associated with less drinking (P = 0.035) and exercising more often (P = 0.001) and for longer (P = 0.001) and healthier reasons for weight control (P = 0.002), despite no differences in frequency of weighing and @entity1 . The results showed that weight overestimation, independent of weight status, is associated with risky lifestyles, weight control behaviors, and mental conditions. Preventive interventions should focus not only on @entity0 , but also on body weight overestimation.

title: Overestimation of own body weights in female university students: associations with lifestyles, weight control behaviors and XXXX .

answer: @entity1


abstract: BACKGROUND: @entity0 who snore but do not have gas exchange abnormalities or alterations of sleep architecture have @entity4 ( @entity4 ). Since increasing evidence suggest that @entity4 may be associated with morbidity, we hypothesized that assessing genome-wide gene expression in peripheral blood leukocytes (PBL) will identify a distinct signature in @entity4 @entity0 . METHODS: @entity0 (aged 4-9 years) with and without habitual snoring and a normal @entity3 were designated as either @entity4 or controls. Whole genome expression profiles of PBL and metabolic parameters in 30 @entity0 with @entity4 and 30 age-, gender-, ethnicity-, and BMI-matched controls were compared. Pathway-focused gene network analysis of the PBL transcriptome was performed. Metabolic parameters were measured in an independent follow-up cohort of 98 @entity0 (64 @entity4 and 34 controls) to evaluate the computationally derived findings. RESULTS: @entity4 was not associated with a distinct transcriptional signature in PBL. Exploratory functional network analysis of enriched gene sets identified a number of putative pathways-including those mapping to insulin signaling, adipocyte differentiation, and @entity1 -with significant alterations in @entity2 metabolism and insulin sensitivity emerging in the follow-up cohort of @entity0 with @entity4 , but no differences in lipid profiles. CONCLUSIONS: @entity4 @entity0 do not exhibit global perturbations in their PBL transcriptional response, suggesting that current normative @entity3 criteria are overall valid. However, subtle differences in functionally coherent pathways involved in glycemic homeostasis were detected and confirmed in a larger independent pediatric cohort indicating that @entity4 may carry increased risk for end-organ morbidity in susceptible @entity0 .

title: Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring XXXX with normal polysomnographic findings.

answer: @entity0


abstract: @entity2 ions in dentifrices for treating 'hypersensitive' dentin are believed to act directly on intradental nerves by raising extracellular @entity2 ion concentration ([K+]o) sufficiently to prevent action potential generation by axonal accommodation. However, the [K+]o necessary to block nerve conduction is not precisely known, nor is it certain that K+ can diffuse from a dentifrice in sufficient amounts to inactivate intradental nerves. To establish more accurately the [K+]o required to block nerve conduction under controlled conditions, we studied the effects of increased [K+]o on the sizes of @entity6 ( @entity6 ) recorded from @entity0 spinal nerves in vitro. [K+]o was increased by the addition of either KCl or KNO3 to Krebs' solutions applied to the central portion of the nerves. @entity6 attenuation increased in a dose-dependent manner as [K+]o was raised in the 8 to 64 mmol/L range, and complete block was generally produced with solutions containing at least 32 mmol/L K+. @entity6 attenuation was reversible, and recovery times increased with increasing [K+]o. The effects of @entity4 and KNO3 solutions were the same for all [K+]o tested. Half-maximal (50%) reduction in the A beta-fiber component of the @entity6 occurred with 17.4 mmol/L K+, and with 17.8 mmol/L and 19.3 mmol/L K+, respectively, for the A delta- and @entity5 components. Control experiments with @entity1 and @entity3 confirmed that the conduction block observed with increased [K+]o was not due to increased solution osmolarity or ionic strength.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of XXXX ions on action potential conduction in A- and C-fibers of @entity0 spinal nerves.

answer: @entity2


abstract: @entity2 ions in dentifrices for treating 'hypersensitive' dentin are believed to act directly on intradental nerves by raising extracellular @entity2 ion concentration ([K+]o) sufficiently to prevent action potential generation by axonal accommodation. However, the [K+]o necessary to block nerve conduction is not precisely known, nor is it certain that K+ can diffuse from a dentifrice in sufficient amounts to inactivate intradental nerves. To establish more accurately the [K+]o required to block nerve conduction under controlled conditions, we studied the effects of increased [K+]o on the sizes of @entity6 ( @entity6 ) recorded from @entity0 spinal nerves in vitro. [K+]o was increased by the addition of either KCl or KNO3 to Krebs' solutions applied to the central portion of the nerves. @entity6 attenuation increased in a dose-dependent manner as [K+]o was raised in the 8 to 64 mmol/L range, and complete block was generally produced with solutions containing at least 32 mmol/L K+. @entity6 attenuation was reversible, and recovery times increased with increasing [K+]o. The effects of @entity4 and KNO3 solutions were the same for all [K+]o tested. Half-maximal (50%) reduction in the A beta-fiber component of the @entity6 occurred with 17.4 mmol/L K+, and with 17.8 mmol/L and 19.3 mmol/L K+, respectively, for the A delta- and @entity5 components. Control experiments with @entity1 and @entity3 confirmed that the conduction block observed with increased [K+]o was not due to increased solution osmolarity or ionic strength.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of @entity2 ions on action potential conduction in A- and C-fibers of XXXX spinal nerves.

answer: @entity0


abstract: OBJECTIVES: This study evaluated the predictive value of T wave amplitude and ST segment level on lead I for @entity6 , a first @entity4 , @entity5 and @entity2 in middle-aged and elderly @entity0 . BACKGROUND: Certain ST-T wave characteristics may reflect favorable autonomic cardiac control. Slight ST segment elevation has been reported to indicate a low risk of @entity2 mortality. METHODS: A total of 876 @entity0 , born between 1900 and 1920, participated in periodic medical examinations and were followed up with respect to morbidity and mortality from 1960 to 1985. In 1985, the remaining cohort was extended to 836 elderly @entity0 from the same birth cohort who were followed up until 1990. Relative risks in categories of T wave amplitude and ST segment level were estimated by survival analysis. RESULTS: Both middle-aged and elderly @entity0 with T wave amplitudes > or = 0.15 mV had a lower risk of @entity4 , @entity2 and @entity5 than @entity0 with T wave amplitudes 0.05 to 0.15 mV. The adjusted relative risk of @entity2 was 0.5 (95% confidence interval [CI] 0.2 to 1.0); in @entity0 with T wave amplitude < or = 0.05 mV, relative risk was 2.0 (95% CI 1.3 to 3.1). Slight ST segment elevation was also associated with decreased risk: relative risk 0.5 (95% CI 0.3 to 1.0) compared with the isoelectric ST segment level. In @entity0 with ST segment @entity3 , relative risk was 2.2 (95% CI 1.4 to 3.4). The association of T wave amplitude and ST segment level were independent of each other. CONCLUSIONS: In addition to the elevated risk of @entity2 that is associated with ST-T wave abnormalities, we observed that normal variations in repolarization characteristics are predictive of future @entity1 .

title: ST segment and T wave characteristics as indicators of XXXX risk: the Zutphen Study.

answer: @entity2


abstract: The @entity3 @entity1 suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many @entity0 @entity1 . Therefore, a central challenge in @entity0 @entity1 therapy is the identification of pathways that control @entity1 cell survival and chemosensitivity in the absence of functional @entity3 . The @entity3 -related transcription factors @entity5 and @entity6 exhibit distinct functions   @entity6 mediates chemosensitivity while @entity5 promotes proliferation and cell survival   and are both overexpressed in @entity4 ( @entity4 ). However, how @entity5 and @entity6 interact functionally and govern the balance between prosurvival and proapoptotic programs in SCC remains elusive. Here, we identify a microRNA-dependent mechanism of @entity5 / @entity6 crosstalk that regulates @entity3 -independent survival of both @entity0 and @entity2 SCC. We first discovered that a subset of @entity5 -regulated microRNAs target @entity6 for inhibition. One of these, @entity7 -5p, expression of which was repressed by @entity5 , was activated by proapoptotic @entity6 isoforms in both normal cells and @entity1 cells in vivo. Chemotherapy caused @entity5 / @entity6 -dependent induction of this microRNA, thereby limiting chemosensitivity due to microRNA-mediated feedback inhibition of @entity6 . Importantly, inhibiting @entity7 interrupted this feedback and thereby suppressed @entity1 cell viability and induced dramatic chemosensitivity both in vitro and in vivo. Thus, we have identified a direct, microRNA-dependent regulatory circuit mediating inducible chemoresistance, whose inhibition may provide a new therapeutic opportunity in @entity3 -deficient @entity1 .

title: A microRNA-dependent program controls @entity3 -independent survival and chemosensitivity in @entity0 and @entity2 XXXX .

answer: @entity4


abstract: The @entity3 @entity1 suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many @entity0 @entity1 . Therefore, a central challenge in @entity0 @entity1 therapy is the identification of pathways that control @entity1 cell survival and chemosensitivity in the absence of functional @entity3 . The @entity3 -related transcription factors @entity5 and @entity6 exhibit distinct functions   @entity6 mediates chemosensitivity while @entity5 promotes proliferation and cell survival   and are both overexpressed in @entity4 ( @entity4 ). However, how @entity5 and @entity6 interact functionally and govern the balance between prosurvival and proapoptotic programs in SCC remains elusive. Here, we identify a microRNA-dependent mechanism of @entity5 / @entity6 crosstalk that regulates @entity3 -independent survival of both @entity0 and @entity2 SCC. We first discovered that a subset of @entity5 -regulated microRNAs target @entity6 for inhibition. One of these, @entity7 -5p, expression of which was repressed by @entity5 , was activated by proapoptotic @entity6 isoforms in both normal cells and @entity1 cells in vivo. Chemotherapy caused @entity5 / @entity6 -dependent induction of this microRNA, thereby limiting chemosensitivity due to microRNA-mediated feedback inhibition of @entity6 . Importantly, inhibiting @entity7 interrupted this feedback and thereby suppressed @entity1 cell viability and induced dramatic chemosensitivity both in vitro and in vivo. Thus, we have identified a direct, microRNA-dependent regulatory circuit mediating inducible chemoresistance, whose inhibition may provide a new therapeutic opportunity in @entity3 -deficient @entity1 .

title: A microRNA-dependent program controls XXXX -independent survival and chemosensitivity in @entity0 and @entity2 @entity4 .

answer: @entity3


abstract: The @entity3 @entity1 suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many @entity0 @entity1 . Therefore, a central challenge in @entity0 @entity1 therapy is the identification of pathways that control @entity1 cell survival and chemosensitivity in the absence of functional @entity3 . The @entity3 -related transcription factors @entity5 and @entity6 exhibit distinct functions   @entity6 mediates chemosensitivity while @entity5 promotes proliferation and cell survival   and are both overexpressed in @entity4 ( @entity4 ). However, how @entity5 and @entity6 interact functionally and govern the balance between prosurvival and proapoptotic programs in SCC remains elusive. Here, we identify a microRNA-dependent mechanism of @entity5 / @entity6 crosstalk that regulates @entity3 -independent survival of both @entity0 and @entity2 SCC. We first discovered that a subset of @entity5 -regulated microRNAs target @entity6 for inhibition. One of these, @entity7 -5p, expression of which was repressed by @entity5 , was activated by proapoptotic @entity6 isoforms in both normal cells and @entity1 cells in vivo. Chemotherapy caused @entity5 / @entity6 -dependent induction of this microRNA, thereby limiting chemosensitivity due to microRNA-mediated feedback inhibition of @entity6 . Importantly, inhibiting @entity7 interrupted this feedback and thereby suppressed @entity1 cell viability and induced dramatic chemosensitivity both in vitro and in vivo. Thus, we have identified a direct, microRNA-dependent regulatory circuit mediating inducible chemoresistance, whose inhibition may provide a new therapeutic opportunity in @entity3 -deficient @entity1 .

title: A microRNA-dependent program controls @entity3 -independent survival and chemosensitivity in XXXX and @entity2 @entity4 .

answer: @entity0


abstract: The @entity3 @entity1 suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many @entity0 @entity1 . Therefore, a central challenge in @entity0 @entity1 therapy is the identification of pathways that control @entity1 cell survival and chemosensitivity in the absence of functional @entity3 . The @entity3 -related transcription factors @entity5 and @entity6 exhibit distinct functions   @entity6 mediates chemosensitivity while @entity5 promotes proliferation and cell survival   and are both overexpressed in @entity4 ( @entity4 ). However, how @entity5 and @entity6 interact functionally and govern the balance between prosurvival and proapoptotic programs in SCC remains elusive. Here, we identify a microRNA-dependent mechanism of @entity5 / @entity6 crosstalk that regulates @entity3 -independent survival of both @entity0 and @entity2 SCC. We first discovered that a subset of @entity5 -regulated microRNAs target @entity6 for inhibition. One of these, @entity7 -5p, expression of which was repressed by @entity5 , was activated by proapoptotic @entity6 isoforms in both normal cells and @entity1 cells in vivo. Chemotherapy caused @entity5 / @entity6 -dependent induction of this microRNA, thereby limiting chemosensitivity due to microRNA-mediated feedback inhibition of @entity6 . Importantly, inhibiting @entity7 interrupted this feedback and thereby suppressed @entity1 cell viability and induced dramatic chemosensitivity both in vitro and in vivo. Thus, we have identified a direct, microRNA-dependent regulatory circuit mediating inducible chemoresistance, whose inhibition may provide a new therapeutic opportunity in @entity3 -deficient @entity1 .

title: A microRNA-dependent program controls @entity3 -independent survival and chemosensitivity in @entity0 and XXXX @entity4 .

answer: @entity2


abstract: UNASSIGNED: @entity0 Wharton's Jelly-derived Mesenchymal Stem Cells (hWJ-MSCs) are easily available cells without transplant rejection problems or ethical concerns compared to bone-marrow-derived MSCs for prospective clinical applications. These cells display immunosuppressive properties and may be able to play an important role in @entity6 . Regulatory T-cells (Treg) are important to prevent @entity6 development. Interleukin 35 (IL-35) induces the proliferation of Treg cell populations and reduces the activity of T helper 17 (Th17) and T helper 1 (Th1) cells, which play a central role in @entity2 and @entity6 .Recent studies identified IL-35 as a new inhibitory cytokine required for the suppressive function of Treg cells. We created IL-35-producing hWJ-MSCs as a good vehicle for @entity2 and     @entity6 .     We     isolated     hWJ-MSCs     based     on     explant     culture.     HWJ-MSCs were transduced at MOI=50 ( @entity3 ) with lentiviral particles harboring @entity1 Interleukin 35 (mIL-35). Expression of IL-35 in hWJ-MSCs was quantified by an IL-35 ELISA kit.IL-35 bioactivity was analyzed by inhibiting the proliferation of @entity1 splenocytes using CFSE cell proliferation kit. Frequency of @entity5 +CD25+ @entity7 low/neg @entity4 + Treg cells was measured by flow cytometry. There was an up to 85% GFP positive transduction rate, and the cells successfully released a high level of mIL-35 protein (750 ng/ml). IL-35 managed to inhibit @entity5 + T cell proliferation with @entity8 , and improved the frequency of Treg cells.Our data suggest that transduced hWJ-MSCs overexpressing IL-35 may provide a useful approach for basic research on gene therapy for @entity6 .

title: In Vitro Generation of IL-35-expressing XXXX Wharton's Jelly-derived Mesenchymal Stem Cells Using Lentiviral Vector.

answer: @entity0


abstract: BACKGROUND: The left thoracoabdominal (LTA) approach is the conventional way to treat @entity6 ( @entity8 ). The study was to review the outcome of the LTA approach with @entity6 of the @entity8 in a single institution in China. METHODS: 135 consecutive @entity6 of @entity8 @entity0 who underwent surgical treatment were retrospectively analyzed; data gathered included basic information on the @entity1 , surgical approach, @entity4 and survival rate. RESULTS: LTA esophagogastrectomy was performed in all @entity0 . No @entity0 received allogeneic blood transfusion during the operation. Among the resective procedures, proximal gastrectomy was performed in 122 cases. The mean operation time was 150 min (90-240). R(0) resection was obtained in 120 @entity0 (88.9%). Two @entity0 developed @entity7 2 days after surgery. Contrast swallow revealed a leak at the @entity3 in 2 @entity0 . One early anastomotic stricture was observed radiologically, and @entity2 was observed in 3 @entity0 . The number of @entity0 with @entity9 and wound @entity5 were 3 and 5, respectively. The percentage was zero in-hospital deaths. The overall survival rates at 1 year and 2 years were 89.2 and 69%, respectively. The median survival was 27.1 months. CONCLUSION: LTA esophagogastrectomy has a major role in the management of @entity6 of the @entity8 , at least in the northern Henan Province of China.

title: Left thoracoabdominal approach in surgical treatment of XXXX in the Northern Henan Province of China.

answer: @entity6


abstract: BACKGROUND: Trigeminal @entity2 is a rare, devastating condition that can be intractable and resistant to treatment. When medical treatment fails, invasive options are limited. @entity4 ( @entity4 ) is a relatively recent technique introduced to treat central @entity1 . The use of @entity4 to treat trigeminal neuropathic or deafferentation @entity3 is not widespread and clinical data in the medical literature that demonstrate efficacy are limited. METHOD: We retrospectively reviewed @entity0 with trigeminal neuropathic or trigeminal deafferentation @entity3 who were treated at the Oregon Health _ Science University between 2001 and 2008 by 1 neurosurgeon using @entity4 . RESULTS: Eight of 11 @entity0 (3 male, 8 female) underwent successful permanent implantation of an @entity4 system. All 8 @entity0 reported initial @entity3 control. Three failed to experience continued @entity3 control (6 months of follow-up). Five continued to experience long-term @entity3 control (mean follow-up, 33 months). Average programming sessions were 2.2/year (all 8 @entity0 ) and 1.55/year (5 @entity0 who sustained long-term @entity3 control). @entity0 with anesthesia dolorosa or trigeminal deafferentation @entity3 who had previously undergone ablative trigeminal procedures responded poorly to @entity4 . We encountered no perioperative complications. CONCLUSION: @entity4 is a safe and potentially effective therapy in certain @entity0 with @entity2 .

title: XXXX for trigeminal neuropathic or deafferentation @entity3 : an institutional case series experience.

answer: @entity4


abstract: BACKGROUND: Trigeminal @entity2 is a rare, devastating condition that can be intractable and resistant to treatment. When medical treatment fails, invasive options are limited. @entity4 ( @entity4 ) is a relatively recent technique introduced to treat central @entity1 . The use of @entity4 to treat trigeminal neuropathic or deafferentation @entity3 is not widespread and clinical data in the medical literature that demonstrate efficacy are limited. METHOD: We retrospectively reviewed @entity0 with trigeminal neuropathic or trigeminal deafferentation @entity3 who were treated at the Oregon Health _ Science University between 2001 and 2008 by 1 neurosurgeon using @entity4 . RESULTS: Eight of 11 @entity0 (3 male, 8 female) underwent successful permanent implantation of an @entity4 system. All 8 @entity0 reported initial @entity3 control. Three failed to experience continued @entity3 control (6 months of follow-up). Five continued to experience long-term @entity3 control (mean follow-up, 33 months). Average programming sessions were 2.2/year (all 8 @entity0 ) and 1.55/year (5 @entity0 who sustained long-term @entity3 control). @entity0 with anesthesia dolorosa or trigeminal deafferentation @entity3 who had previously undergone ablative trigeminal procedures responded poorly to @entity4 . We encountered no perioperative complications. CONCLUSION: @entity4 is a safe and potentially effective therapy in certain @entity0 with @entity2 .

title: @entity4 for trigeminal neuropathic or deafferentation XXXX : an institutional case series experience.

answer: @entity3


abstract: UNASSIGNED: In this comparative cross-sectional study, possible associations between maternal anti-HLA class I antibodies and birth weight in @entity1 are explored. Although commonly detected in pregnancies and generally regarded as harmless, it has been suggested that such antibodies might be associated with @entity2 ( @entity2 ). As a link between @entity2 due to human platelet antigen 1a-specific antibodies and reduced birth weight in @entity0 has previously been demonstrated, we wanted to explore whether maternal anti-HLA class I antibodies might also affect birth weight. To examine this, suspected cases of @entity2 referred to the Norwegian National Unit for Platelet Immunology during the period 1998-2009 were identified. Pregnancies where the only finding was maternal anti-HLA class I antibodies were included. An unselected group of pregnant @entity0 participating in a prospective study investigating maternal-fetal hemodynamics at the University Hospital North Norway during the years 2006-2010 served as controls. Twenty-nine percent of controls had anti-HLA class I antibodies. The @entity1 neonates had a significantly lower adjusted birth weight (linear regression, P=0.036) and significantly higher odds of being small for gestational age (OR=6.72, P<0.001) compared with controls. Increasing anti-HLA class I antibody levels in the mother were significantly associated with lower birth weight and placental weight among @entity1 neonates, but not among controls. These results indicate that maternal anti-HLA class I antibodies in @entity1 neonates are associated with reduced fetal growth. Further studies are needed to test if placental function is affected.

title: Maternal anti-HLA class I antibodies are associated with reduced birth weight in XXXX neonates.

answer: @entity1


abstract: UNASSIGNED: Automated analysis and differentiation of mild @entity1 and @entity3 using MR images is clinically significant in @entity2 . @entity3 ( @entity3 ) is a fatal and common form of @entity4 that progressively affects the @entity0 . Shape descriptors could better differentiate the morphological alterations of brain structures and aid in the development of prospective disease modifying therapies. @entity5 is considered as a significant biomarker in the @entity3 diagnosis. In this work, a method has been proposed to differentiate MCI from the healthy normal and @entity3 subjects using Laplace-Beltrami (LB) eigen value shape descriptors. Prior to this, Reaction Diffusion (RD) level set is used to segment the ventricles in MR images and the results are validated against the @entity6 ( @entity6 ). LB eigen values are infinite series of spectrum that describes the intrinsic geometry of objects. Most significant LB shape descriptors are identified and their performance is analysed using linear Support Vector Machine (SVM) classifier. Results show that, the RD level set is able to segment the ventricles. The segmented ventricles are found to have high correlation with @entity6 . The eigen values in the LB spectrum could show distinction in the feature space better than the geometric features. High accuracy is observed in the classification results of linear SVM. The proposed automated system is able to distinctly separate the MCI from normal and @entity3 subjects. Thus this pipeline of work seems to be clinically significant in the automated analysis of dementic subjects.

title: A Method to Differentiate Mild XXXX and Alzheimer in MR Images using Eigen Value Descriptors.

answer: @entity1


abstract: PURPOSE: A phase II study of stent therapy for unresectable malignant @entity1 was conducted to ascertain the clinical efficacy, safety, and procedural feasibility. METHODS: Inclusion criteria comprised unresectable obstruction of the rectum or sigmoid colon; no other apparent stenosis; performance status by Eastern Cooperative Oncology Group  <=3; and maintained major organ function. The treatment protocol was to place an uncovered metal stent through the anus in an obstructive portion under x-ray fluoroscopic guidance. The @entity0 were followed for 4 weeks after therapy, and the degree of improvement in subjective symptoms lasting >= 2 weeks was assessed as effective when the @entity0 was decompressed with stent, or ineffective when not decompressed. Rate of clinical efficacy was defined as the proportion of effective cases. RESULTS: The @entity0 of the study comprised 33 @entity0 (13 @entity0 and 20 @entity0 ; mean age, 60 y). Rate of procedure completion was 97.0% (32/33). Treatment was effective in 27 @entity0 , ineffective in 4, and unassessable in 1, yielding a clinical efficacy rate of 81.8% (27/33). @entity3 owing to underlying disease (n=3), stent removal owing to anal @entity2 (n=1), and occlusion at another location (n=1) were noted. No recurrences were seen among clinically effective cases. Adverse reactions included grades 2 to 3 @entity4 (n=12), @entity2 (n=5), @entity5 (n=1), and @entity6 (n=1), but no grade 4 adverse reactions or treatment-related @entity3 were identified. CONCLUSIONS: Stent therapy for unresectable malignant @entity1 is effective, safe, and feasible.

title: Phase II clinical study on stent therapy for unresectable malignant XXXX (JIVROSG-0206).

answer: @entity1


abstract: PURPOSE OF REVIEW: Fluid resuscitation in @entity2 @entity0 with @entity4 is controversially discussed in the literature. The coincidence of @entity7 complicates management of these @entity0 . This article summarizes the current knowledge on nonblood component fluid resuscitation and choice of fluids in @entity0 with @entity6 . RECENT FINDINGS: Whereas current evidence suggests the efficacy of fluid therapy in @entity4 without active @entity4 , experimental and clinical data demonstrate that aggressive volume challenge may be futile or even deleterious in the setting of uncontrolled @entity4 . Large amounts of isotonic crystalloids may be associated with @entity8 , @entity3 and @entity1 . In @entity0 with traumatic @entity7 hypertonic solutions may positively influence @entity1 and intracranial pressure without affecting neurologic outcome or mortality. SUMMARY: To date no large-scale clinical studies exist to either support or refute the use of nonblood component fluid resuscitation of @entity4 in @entity2 @entity0 . The optimal choice of fluid remains to be determined, but existing evidence suggests avoiding crystalloids in favor of hypertonic solutions. The role of modern, iso-oncotic colloids in the treatment of @entity4 has not yet been sufficiently defined. In @entity0 with concomitant @entity7 , arterial @entity5 must be avoided and infusion of @entity9 solutions is obsolete, whereas administration of hypertonic solutions may exert beneficial effects beyond hemodynamic stabilization.

title: Fluid resuscitation in XXXX @entity0 .

answer: @entity6


abstract: PURPOSE OF REVIEW: Fluid resuscitation in @entity2 @entity0 with @entity4 is controversially discussed in the literature. The coincidence of @entity7 complicates management of these @entity0 . This article summarizes the current knowledge on nonblood component fluid resuscitation and choice of fluids in @entity0 with @entity6 . RECENT FINDINGS: Whereas current evidence suggests the efficacy of fluid therapy in @entity4 without active @entity4 , experimental and clinical data demonstrate that aggressive volume challenge may be futile or even deleterious in the setting of uncontrolled @entity4 . Large amounts of isotonic crystalloids may be associated with @entity8 , @entity3 and @entity1 . In @entity0 with traumatic @entity7 hypertonic solutions may positively influence @entity1 and intracranial pressure without affecting neurologic outcome or mortality. SUMMARY: To date no large-scale clinical studies exist to either support or refute the use of nonblood component fluid resuscitation of @entity4 in @entity2 @entity0 . The optimal choice of fluid remains to be determined, but existing evidence suggests avoiding crystalloids in favor of hypertonic solutions. The role of modern, iso-oncotic colloids in the treatment of @entity4 has not yet been sufficiently defined. In @entity0 with concomitant @entity7 , arterial @entity5 must be avoided and infusion of @entity9 solutions is obsolete, whereas administration of hypertonic solutions may exert beneficial effects beyond hemodynamic stabilization.

title: Fluid resuscitation in @entity6 XXXX .

answer: @entity0


abstract: OBJECTIVE: The aim of this study was to describe a new @entity2 thyroplasty medializing implant and evaluate its usefulness. MATERIAL AND METHOD: Retrospective study of 9 male @entity0 with severe unilateral vocal fold @entity3 after @entity1 surgery who underwent type I thyoplasty with arytenoid adduction under general anesthesia. Preoperative and postoperative glottal closure and voice function were evaluated by acoustic analysis (Jitter %, Shimmer %, NHR), stroboscopic findings, maximum phonation time, mean airflow rate, voice handicap index and computed tomography findings. These tests were evaluated before and 3 months after surgery. RESULT: All acoustic parameters improved after surgery. In stroboscopic findings, symmetrical mucosal waves were identified in 3 cases. Maximum phonation time prolonged, mean flow rate decreased and voice handicap index improved. In computed-tomography findings, breakage, deformation, dropped and migration of @entity2 plate were not identified. CONCLUSION: In surgery of vocal fold paralyzed @entity0 , it is necessary to reconstruct vocal fold in physiological state at the time of phonation. Using the @entity2 plate developed for this purpose, all @entity0 obtained good vocal improvement.

title: [Investigation of Type I Thyroplasty Using XXXX Implant].

answer: @entity2


abstract: Implant supported rehabilitation has become very common in treatment plans nowadays, yet many @entity0 lack the vertical and horizontal bone dimensions required for endosseous implant insertion. Distraction osteogenesis is a technique in which bone is generated by progressive elongation of two bone fragments following an osteotomy or corticotomy. Distraction osteogenesis of the alveolar ridge as a treatment modality in implant dentistry is a very useful technique that allows for adequate bone formation suitable for implant insertion. Alveolar distraction can be unidirectional, bidirectional, multidirectional or horizontal. Alveolar distraction osteogenesis can be performed by using intraosseous distraction devices, intraosseous distraction implants or by extraosseous devices which are the most prevalent today. Distraction osteogenesis has many advantages such as gradual lengthening of the bone with no need for an autogenous bone graft and lack of the associated donor site morbidity as well as distraction of the surrounding soft tissue together with the transported bone. One of the major challenges when using alveolar distraction osteogenesis is controlling the vector of distraction, this problem should be further addressed in future researches. We describe different methods for alveolar distraction osteogenesis, including the surgical procedure, latency period, lengthening and consolidation period. We also discuss the advantages, disadvantages and complications of the method. In this manuscript a case of @entity1 following mandibular @entity2 and @entity3 and the alveolar bone is presented. This @entity0 was treated by alveolar distraction osteogenesis with excellent results. This @entity0 was later rehabilitated . using endosseous implants as demonstrated by radiographs. Alveolar distraction osteogenesis provides a method to regain both hard tissue and soft tissue without additional grafting and is an efficient modality in cases of medium to severe @entity4 .

title: [Distraction osteogenesis of XXXX prior to dental rehabilitation].

answer: @entity4