abstract: PURPOSE: All previous studies reported the benefit of antibiotic prophylaxis in cirrhotic @entity0 with either a mixture of nonvariceal and variceal @entity4 or variceal @entity4 alone. Reports on sole peptic ulcers @entity4 are lacking. We aimed to assess the effect of antibiotic prophylaxis in cirrhotic @entity0 with peptic @entity5 after endoscopic interventions and the risk factors associated with recurrent @entity4 . METHODS: A cross-sectional retrospective chart review study was conducted on 148 cirrhotic @entity0 with acute peptic ulcer @entity4 who underwent therapeutic endoscopic procedures. @entity0 who received prophylactic intravenous @entity6 were classified as group A (n  =  38) and those who did not receive antibiotics were classified as group B (n  =  110). The outcomes were prevention of @entity3 , length of hospital stay, time of rebleeding, and @entity2 . RESULTS: More @entity0 suffered from recurrent @entity4 and @entity3 in group B than those in group A (28.2 vs. 5.3  %; p  =  0.003, and 26.4 vs. 10.5  %; p  =  0.043, respectively). The risk factors associated with recurrent @entity4 were being male (OR  =  3.4; p  =  0.024), those with advanced stage of @entity1 with @entity0 -Pugh's class C (OR  =  3.8; p  <  0.001), and those without antibiotic prophylaxis (OR  =  8.9; p  =  0.003). The observed 30-day survival was virtually identical for both groups (p  =  0.279). CONCLUSIONS: Antibiotic prophylaxis in cirrhotic @entity0 after endoscopic interventions for acute peptic ulcer @entity4 reduced @entity3 and decreased rebleeding. Male gender, @entity1 @entity0 -Pugh's class C, and no antibiotic prophylaxis were independent predictors of recurrent @entity4 . Further studies should be directed to explore ways to improve the overall outcome of these @entity0 .

title: The effect of systemic antibiotic prophylaxis for cirrhotic @entity0 with peptic XXXX after endoscopic interventions.

answer: @entity5


abstract: PURPOSE: All previous studies reported the benefit of antibiotic prophylaxis in cirrhotic @entity0 with either a mixture of nonvariceal and variceal @entity4 or variceal @entity4 alone. Reports on sole peptic ulcers @entity4 are lacking. We aimed to assess the effect of antibiotic prophylaxis in cirrhotic @entity0 with peptic @entity5 after endoscopic interventions and the risk factors associated with recurrent @entity4 . METHODS: A cross-sectional retrospective chart review study was conducted on 148 cirrhotic @entity0 with acute peptic ulcer @entity4 who underwent therapeutic endoscopic procedures. @entity0 who received prophylactic intravenous @entity6 were classified as group A (n  =  38) and those who did not receive antibiotics were classified as group B (n  =  110). The outcomes were prevention of @entity3 , length of hospital stay, time of rebleeding, and @entity2 . RESULTS: More @entity0 suffered from recurrent @entity4 and @entity3 in group B than those in group A (28.2 vs. 5.3  %; p  =  0.003, and 26.4 vs. 10.5  %; p  =  0.043, respectively). The risk factors associated with recurrent @entity4 were being male (OR  =  3.4; p  =  0.024), those with advanced stage of @entity1 with @entity0 -Pugh's class C (OR  =  3.8; p  <  0.001), and those without antibiotic prophylaxis (OR  =  8.9; p  =  0.003). The observed 30-day survival was virtually identical for both groups (p  =  0.279). CONCLUSIONS: Antibiotic prophylaxis in cirrhotic @entity0 after endoscopic interventions for acute peptic ulcer @entity4 reduced @entity3 and decreased rebleeding. Male gender, @entity1 @entity0 -Pugh's class C, and no antibiotic prophylaxis were independent predictors of recurrent @entity4 . Further studies should be directed to explore ways to improve the overall outcome of these @entity0 .

title: The effect of systemic antibiotic prophylaxis for cirrhotic XXXX with peptic @entity5 after endoscopic interventions.

answer: @entity0


abstract: PURPOSE: Tear film proteins adhere to the surface of contact lenses (CLs). While the proteins in the tears have been extensively studied with various proteomic techniques, adhered proteins to CLs are less studied. In this pilot study, we have separated proteins with 2D gel electrophoresis prior to the conventional @entity5 ( @entity5 ) in order to analyse the deposited proteins on hydrogel CLs from myopic @entity0 . METHODS: pHEMA and @entity2 hydrogel CLs worn by 3 @entity0 for different time lengths were analysed. After wear, the CLs were frozen at -20  C. Proteins were extracted in lysis buffer, separated on 12% @entity4 gels and @entity1 -stained. Protein spots were excised and identified with liquid chromatography - tandem @entity5 . RESULTS: Deposited proteins were extracted with a yield of 26-66   g and separated by 2D gel electrophoresis. The @entity1 -stained gels showed similar protein patterns independent of the @entity0 , hydrogel type and wear time. Seventy-two spots were analysed with @entity5 , representing at least 12 different tear film proteins or protein fragments. CONCLUSIONS: Deposited tear film proteins from a single set of CLs worn for 1  day can successfully be analysed first with 2D gel electrophoresis and subsequently with @entity5 , thus making examination of individual @entity0 possible. The protein composition appeared homogeneous between the test @entity0 which is a necessity for additional comparison analysis. The molecular masses of the identified proteins indicate that protein degradation occurs only as a minor event. Myopic @entity0 were investigated in this pilot study, but the combined techniques can easily be applied to other @entity3 .

title: Tear film proteins deposited on high water content contact lenses identified with two-dimensional gel electrophoresis and XXXX .

answer: @entity5


abstract: UNASSIGNED: 38 I. 38 II. 39 III. 39 IV. 41 V. 41 VI. 41 VII. 42 42 References 42 SUMMARY: @entity0 ( @entity1 ) is a key phytohormone promoting abiotic stress tolerance as well as developmental processes such as seed dormancy. A spatiotemporal map of @entity1 concentrations would greatly advance our understanding of the cell type and timing of @entity1 action. Organ and tissue-level @entity1 measurements, as well as indirect in  vivo measurements such as cell-specific transcriptional analysis of @entity1 metabolic enzymes and @entity1 -responsive promoters, have all contributed to current views of the localization and timing of @entity1 accumulations. Recently developed F  rster resonance energy transfer (FRET) biosensors for @entity1 that sense @entity1 levels directly promise to add unprecedented resolution to in  vivo @entity1 spatiotemporal mapping and expand our knowledge of the mechanisms controlling @entity1 levels in space and time.

title: A new look at stress: XXXX patterns and  dynamics at high-resolution.

answer: @entity0


abstract: OBJECTIVES: Postoperative recurrences of @entity3 ( @entity3 ) are usually disseminated and systemic. Recently, the concept of oligo-recurrence, which is theoretically curable by definitive local therapy (DLT), has been proposed in several @entity2 . The aim of this study was to clarify clinical features and outcomes of @entity0 with postoperative oligo-recurrence of @entity3 . METHODS: From 3275 @entity0 with resected pathological stage IA-IIIB @entity3 between 1993 and 2011, a total of 768 @entity0 who developed recurrence were included in this study. Oligo-recurrence was defined as 1-3 loco-regional or distant recurrent lesions restricted to a single organ. Other recurrences were classified as poly-recurrence. Second @entity1 and suspected lesions were excluded. DLT included surgery, stereotactic radiotherapy and radiotherapy with a 45 Gy or higher dose, performed with curative intent. RESULTS: Oligo-recurrence was identified in 162 (21%) @entity0 , mainly as a solitary recurrence (n = 129, 80%) in regional lymph nodes, brain, lung, bone and adrenal gland, and the proportion of @entity0 with oligo-recurrence increased gradually year by year. The @entity0 with oligo-recurrence had more early-staged disease at initial surgery and a longer time to recurrence than those with poly-recurrence. The entire population of oligo-recurrence @entity0 had better @entity4 ( @entity4 ) than those with poly-recurrence (5-year @entity4 : 32.9 vs 9.9%, P < 0.001). For oligo-recurrence, DLT was totally conducted in 105 (65%) @entity0 as initial treatment. Multivariate analyses revealed that the initial DLT was associated with improved @entity4 [odds ratio (OR) 0.44; 95% confidence interval (CI) 0.29-0.68]. The recurrence location and initial pathological stage did not affect @entity4 . The 5-year @entity4 and postoperative progression-free survival rates after DLT were 38.6 and 22.3%, respectively. Of the 10 long-term (>= 5-year) progression-free survivors, 9 were those with a solitary recurrence. CONCLUSIONS: Initial DLT for oligo-recurrence achieved favourable @entity4 in a selected population. Oligo-recurrence curable by DLT was found in a subset of @entity0 who received DLT, mostly as a solitary recurrence.

title: Postoperative oligo-recurrence of XXXX : clinical features and survival   .

answer: @entity3


abstract: Transvascular escape rate of albumin [TERalb, i.e. the fraction of the intravascular mass of albumin (IVMalb) passing to the extravascular space per unit time] was determined from the disappearance of i.v. injected radioiodinated serum albumin in anaesthetized @entity4 during control conditions and during regional venous congestion in the infradiaphragmatic area. Balloon catheters were placed in the portal vein ( @entity2 ) and in the inferior vena cava above (suprahepatic caval congestion) and below (infrahepatic caval congestion) the outlets of the hepatic veins. TERalb was on the average 13% IVMalb.h-1 under basal pressure conditions. TERalb rose significantly (p less than 0.01) during suprahepatic caval and @entity2 to an average of 29 and 19% IVMalb.h-1, respectively. TERalb was positively correlated to the portal pressure (r = 0.75, P less than 0.001). Only a minor increment in TERalb was found during infrahepatic caval congestion. The hepatic share of the increased TERalb during stasis above the hepatic veins was estimated to be threefold that of the extrahepatic splanchnic area. Our results point to filtration of protein, predominantely through the lining of the sinusoids and perisinusoidal space of the liver into the interstitial space around the portal vessels and further into the lymphatics, as the main mechanism of the previously demonstrated marked increase in TERalb in @entity0 with @entity1 due to @entity3 .

title: Increased transvascular escape rate of albumin during experimental portal and @entity1 in the @entity4 . Relation to findings in @entity0 with XXXX .

answer: @entity3


abstract: Transvascular escape rate of albumin [TERalb, i.e. the fraction of the intravascular mass of albumin (IVMalb) passing to the extravascular space per unit time] was determined from the disappearance of i.v. injected radioiodinated serum albumin in anaesthetized @entity4 during control conditions and during regional venous congestion in the infradiaphragmatic area. Balloon catheters were placed in the portal vein ( @entity2 ) and in the inferior vena cava above (suprahepatic caval congestion) and below (infrahepatic caval congestion) the outlets of the hepatic veins. TERalb was on the average 13% IVMalb.h-1 under basal pressure conditions. TERalb rose significantly (p less than 0.01) during suprahepatic caval and @entity2 to an average of 29 and 19% IVMalb.h-1, respectively. TERalb was positively correlated to the portal pressure (r = 0.75, P less than 0.001). Only a minor increment in TERalb was found during infrahepatic caval congestion. The hepatic share of the increased TERalb during stasis above the hepatic veins was estimated to be threefold that of the extrahepatic splanchnic area. Our results point to filtration of protein, predominantely through the lining of the sinusoids and perisinusoidal space of the liver into the interstitial space around the portal vessels and further into the lymphatics, as the main mechanism of the previously demonstrated marked increase in TERalb in @entity0 with @entity1 due to @entity3 .

title: Increased transvascular escape rate of albumin during experimental portal and XXXX in the @entity4 . Relation to findings in @entity0 with @entity3 .

answer: @entity1


abstract: Transvascular escape rate of albumin [TERalb, i.e. the fraction of the intravascular mass of albumin (IVMalb) passing to the extravascular space per unit time] was determined from the disappearance of i.v. injected radioiodinated serum albumin in anaesthetized @entity4 during control conditions and during regional venous congestion in the infradiaphragmatic area. Balloon catheters were placed in the portal vein ( @entity2 ) and in the inferior vena cava above (suprahepatic caval congestion) and below (infrahepatic caval congestion) the outlets of the hepatic veins. TERalb was on the average 13% IVMalb.h-1 under basal pressure conditions. TERalb rose significantly (p less than 0.01) during suprahepatic caval and @entity2 to an average of 29 and 19% IVMalb.h-1, respectively. TERalb was positively correlated to the portal pressure (r = 0.75, P less than 0.001). Only a minor increment in TERalb was found during infrahepatic caval congestion. The hepatic share of the increased TERalb during stasis above the hepatic veins was estimated to be threefold that of the extrahepatic splanchnic area. Our results point to filtration of protein, predominantely through the lining of the sinusoids and perisinusoidal space of the liver into the interstitial space around the portal vessels and further into the lymphatics, as the main mechanism of the previously demonstrated marked increase in TERalb in @entity0 with @entity1 due to @entity3 .

title: Increased transvascular escape rate of albumin during experimental portal and @entity1 in the XXXX . Relation to findings in @entity0 with @entity3 .

answer: @entity4


abstract: Transvascular escape rate of albumin [TERalb, i.e. the fraction of the intravascular mass of albumin (IVMalb) passing to the extravascular space per unit time] was determined from the disappearance of i.v. injected radioiodinated serum albumin in anaesthetized @entity4 during control conditions and during regional venous congestion in the infradiaphragmatic area. Balloon catheters were placed in the portal vein ( @entity2 ) and in the inferior vena cava above (suprahepatic caval congestion) and below (infrahepatic caval congestion) the outlets of the hepatic veins. TERalb was on the average 13% IVMalb.h-1 under basal pressure conditions. TERalb rose significantly (p less than 0.01) during suprahepatic caval and @entity2 to an average of 29 and 19% IVMalb.h-1, respectively. TERalb was positively correlated to the portal pressure (r = 0.75, P less than 0.001). Only a minor increment in TERalb was found during infrahepatic caval congestion. The hepatic share of the increased TERalb during stasis above the hepatic veins was estimated to be threefold that of the extrahepatic splanchnic area. Our results point to filtration of protein, predominantely through the lining of the sinusoids and perisinusoidal space of the liver into the interstitial space around the portal vessels and further into the lymphatics, as the main mechanism of the previously demonstrated marked increase in TERalb in @entity0 with @entity1 due to @entity3 .

title: Increased transvascular escape rate of albumin during experimental portal and @entity1 in the @entity4 . Relation to findings in XXXX with @entity3 .

answer: @entity0


abstract: We assess the in-vivo relationship between international normalized ratio (INR) and @entity3 tests in @entity0 with life-threatening bleeding who received prothrombin complex concentrate (PCC) for warfarin reversal. This was a prospective pilot study in adult @entity0 with @entity1 related to anticoagulation with warfarin. Thromboelastography (TEG), @entity2 generation parameters and INR were assessed at baseline, 30 min, 2 and 24 h after PCC. Changes in laboratory parameters and relationship between INR and @entity3 tests were assessed over time. Eight @entity0 mean [standard deviation (SD)] age 72 (16) were included and received mean (SD) dose of PCC 24 (5)units/kg. Four @entity0 died during the study, all with INR values more than 1.5 thirty minutes after PCC. Mean (SD) INR was 3.0 (1.3) and decreased significantly to 1.8 (0.48) thirty minutes after PCC (P<0.01). Baseline endogenous @entity2 potential and @entity2 peak were 890 nmol/min and 123 nmol and increased significantly to 1943 nmol/min (P<0.01) and 301 nmol (P<0.01) 30 min after PCC administration. Reaction (R)-time decreased significantly (P=0.02), and maximum amplitude and overall coagulation index (CI) significantly increased during treatment (P<0.01, respectively). @entity2 generation and TEG values corrected after PCC administration; however, INR did not fully correct. @entity0 that died tended to be older with prolonged INR values across the study period. INR and TEG values correlated well with @entity2 generation before administration of PCC, but this relationship was lost afterward.

title: Laboratory assessment of warfarin reversal with @entity3 tests versus international normalized ratio in @entity0 with XXXX .

answer: @entity1


abstract: We assess the in-vivo relationship between international normalized ratio (INR) and @entity3 tests in @entity0 with life-threatening bleeding who received prothrombin complex concentrate (PCC) for warfarin reversal. This was a prospective pilot study in adult @entity0 with @entity1 related to anticoagulation with warfarin. Thromboelastography (TEG), @entity2 generation parameters and INR were assessed at baseline, 30 min, 2 and 24 h after PCC. Changes in laboratory parameters and relationship between INR and @entity3 tests were assessed over time. Eight @entity0 mean [standard deviation (SD)] age 72 (16) were included and received mean (SD) dose of PCC 24 (5)units/kg. Four @entity0 died during the study, all with INR values more than 1.5 thirty minutes after PCC. Mean (SD) INR was 3.0 (1.3) and decreased significantly to 1.8 (0.48) thirty minutes after PCC (P<0.01). Baseline endogenous @entity2 potential and @entity2 peak were 890 nmol/min and 123 nmol and increased significantly to 1943 nmol/min (P<0.01) and 301 nmol (P<0.01) 30 min after PCC administration. Reaction (R)-time decreased significantly (P=0.02), and maximum amplitude and overall coagulation index (CI) significantly increased during treatment (P<0.01, respectively). @entity2 generation and TEG values corrected after PCC administration; however, INR did not fully correct. @entity0 that died tended to be older with prolonged INR values across the study period. INR and TEG values correlated well with @entity2 generation before administration of PCC, but this relationship was lost afterward.

title: Laboratory assessment of warfarin reversal with XXXX tests versus international normalized ratio in @entity0 with @entity1 .

answer: @entity3


abstract: We assess the in-vivo relationship between international normalized ratio (INR) and @entity3 tests in @entity0 with life-threatening bleeding who received prothrombin complex concentrate (PCC) for warfarin reversal. This was a prospective pilot study in adult @entity0 with @entity1 related to anticoagulation with warfarin. Thromboelastography (TEG), @entity2 generation parameters and INR were assessed at baseline, 30 min, 2 and 24 h after PCC. Changes in laboratory parameters and relationship between INR and @entity3 tests were assessed over time. Eight @entity0 mean [standard deviation (SD)] age 72 (16) were included and received mean (SD) dose of PCC 24 (5)units/kg. Four @entity0 died during the study, all with INR values more than 1.5 thirty minutes after PCC. Mean (SD) INR was 3.0 (1.3) and decreased significantly to 1.8 (0.48) thirty minutes after PCC (P<0.01). Baseline endogenous @entity2 potential and @entity2 peak were 890 nmol/min and 123 nmol and increased significantly to 1943 nmol/min (P<0.01) and 301 nmol (P<0.01) 30 min after PCC administration. Reaction (R)-time decreased significantly (P=0.02), and maximum amplitude and overall coagulation index (CI) significantly increased during treatment (P<0.01, respectively). @entity2 generation and TEG values corrected after PCC administration; however, INR did not fully correct. @entity0 that died tended to be older with prolonged INR values across the study period. INR and TEG values correlated well with @entity2 generation before administration of PCC, but this relationship was lost afterward.

title: Laboratory assessment of warfarin reversal with @entity3 tests versus international normalized ratio in XXXX with @entity1 .

answer: @entity0


abstract: @entity0 is the leading cause of @entity1 worldwide and @entity2 ( @entity2 ) accounts for a significant proportion of all @entity0 cases. Even so, the underlying mechanism governing @entity2 development remains poorly understood and @entity2 related @entity1 stands high despite decades of intensive investigation. We noted that both miR-138 and @entity3 have been implicated in development of @entity1 . Also, there is a recent report showing the role of miR-138 in mediating DNA damage response by targeting @entity3 . In light of these data, we sought to characterize the role of miR-138 for @entity2 cell growth and cell-cycle progression by regulating @entity3 expression. Results showed that miR-138 is significantly down-regulated in @entity2 tissues as well as in three @entity2 cell lines. After successfully engineering miR-138 overexpression in one of the @entity2 cell lines, NCI-H2081, we observed a remarkable reduction of cell growth and a significant inhibition on cell-cycle progression. Moreover, we were able to show that miR-138 potently inhibits @entity3 expression, which suggests that @entity3 may serve as a downstream executor for miR-138. Consistent with this hypothesis, we found that engineered @entity3 knockdown achieves a similar effect as observed for miR-138 overexpression in terms of @entity2 growth and cell cycle regulation. We also showed that @entity3 overexpression largely abolished miR-138-mediated @entity1 cell growth and cell-cycle progression inhibition, which strongly suggests, at least in vitro, that miR-138 potently regulates @entity2 development by targeting @entity3 . In addition, we found lower miR-138 expression confers @entity2 cells with greater DNA damage repair capacity. Finally, we were able to show miR-138 overexpression inhibits DNA damage repair in @entity2 cells while miR-138 knockdown further facilitates DNA damage repair in these cells after IR. To date, there has been no study showing the role of miR-138/ @entity3 machinery in @entity2 development. Our results may shed a light to development of new lines of @entity2 diagnosis and treatment approaches.

title: MicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting XXXX .

answer: @entity3


abstract: INTRODUCTION: A majority of @entity0 with @entity1 do not have levels of glycated hemoglobin (HbA1c) and low-density lipoprotein @entity4 (LDL-C) under control, either individually or in combination. The objective was to assess the clinical benefits and @entity0 characteristics associated with @entity6 [HbA1c <7% (53  mmol/mol) and LDL-C <100  mg/dL] versus only LDL-C goal achievement in adults with newly diagnosed @entity3 2 @entity1 . METHODS: Newly diagnosed @entity0 with >= 2 measures of LDL-C and @entity5 c were identified in the South Central Veterans Affairs Health Care Network (01/2004-06/2010). The index date was the first @entity5 c assessment within 3  months of the first @entity3 2 @entity1 diagnosis. Multivariate Cox proportional hazards models were used to assess the association between time-varying goal achievement and post-index microvascular and @entity2 . @entity0 characteristics associated with @entity6 in the 7-12  months post-index were identified using a logistic regression. RESULTS: The sample included 16,829 @entity0 . Compared with LDL-C goal achievement, @entity6 was associated with lower risk of microvascular complications [hazard ratio (95% confidence interval): 0.69 (0.63, 0.76)]. Other outcomes did not differ between those two groups. Characteristics associated with @entity6 (44.2% of @entity0 ) include prior @entity6 , older age, and use of lipid-lowering drugs. CONCLUSION: @entity6 in newly diagnosed @entity3 2 @entity1 is associated with a lower risk of microvascular complications versus only LDL-C goal achievement. Although @entity6 rates are suboptimal, early and regular intervention will increase its likelihood. FUNDING: Daiichi Sankyo, Inc., Parsippany, NJ, USA.

title: Glycemic and XXXX Control Versus Single-Goal Control in US Veterans with Newly Diagnosed Type 2 Diabetes: A Retrospective Observational Study.

answer: @entity4


abstract: @entity5 ( @entity5 ) is a complex syndrome characterized by progressive decline in left ventricular function, low exercise tolerance and raised mortality and morbidity. @entity6 plays a major role in @entity5 and progression of most @entity3 . The current recommended goals can theoretically be accomplished via exercise and pharmacological therapy so the aim of the present study was to evaluate the impact of cardiac rehabilitation program on @entity1 and health related quality of life and to determine the correlation between changes in @entity6 and domains of health-related quality of life (HRQoL). Forty @entity0 with @entity5 were diagnosed as having @entity4 ( @entity4 ) with @entity3 . The @entity0 were equally and randomly divided into training and control groups. Only 30 of them completed the study duration. The training group participated in rehabilitation program in the form of circuit-interval aerobic training adjusted according to 55-80% of heart rate reserve for a period of 7  months. Circuit training improved both @entity3 in the training group. On the other hand, only a significant correlation was found between improvement in @entity1 and health related quality of life measured by Kansas @entity2 Questionnaire. It was concluded that improvement in @entity1 as a result of rehabilitation program is one of the important underlying mechanisms responsible for improvement in health-related quality of life in @entity4 @entity0 .

title: Correlation between changes in XXXX and health-related quality of life after cardiac rehabilitation program in @entity4 .

answer: @entity1


abstract: @entity5 ( @entity5 ) is a complex syndrome characterized by progressive decline in left ventricular function, low exercise tolerance and raised mortality and morbidity. @entity6 plays a major role in @entity5 and progression of most @entity3 . The current recommended goals can theoretically be accomplished via exercise and pharmacological therapy so the aim of the present study was to evaluate the impact of cardiac rehabilitation program on @entity1 and health related quality of life and to determine the correlation between changes in @entity6 and domains of health-related quality of life (HRQoL). Forty @entity0 with @entity5 were diagnosed as having @entity4 ( @entity4 ) with @entity3 . The @entity0 were equally and randomly divided into training and control groups. Only 30 of them completed the study duration. The training group participated in rehabilitation program in the form of circuit-interval aerobic training adjusted according to 55-80% of heart rate reserve for a period of 7  months. Circuit training improved both @entity3 in the training group. On the other hand, only a significant correlation was found between improvement in @entity1 and health related quality of life measured by Kansas @entity2 Questionnaire. It was concluded that improvement in @entity1 as a result of rehabilitation program is one of the important underlying mechanisms responsible for improvement in health-related quality of life in @entity4 @entity0 .

title: Correlation between changes in @entity1 and health-related quality of life after cardiac rehabilitation program in XXXX .

answer: @entity4


abstract: PURPOSE: To determine the incidence and the risks factors of peripherally inserted central catheter (PICC)-related infectious complications. MATERIALS AND METHODS: Medical charts of every in- @entity0 that underwent a PICC insertion in our hospital between January 2010 and October 2013 were reviewed. All PICC-related @entity1 were recorded and categorized as catheter-related bloodstream @entity1 (CR-BSI), exit-site @entity1 , and septic @entity2 . RESULTS: Nine hundred and twenty-three PICCs were placed in 644 unique @entity0 , mostly male (68.3%) with a median age of 58 years. 31 (3.4%) PICC-related @entity1 occurred during the study period corresponding to an infection rate of 1.64 per 1000 catheter-days. We observed 27 (87.1%) CR-BSI, corresponding to a rate of 1.43 per 1000 catheter-days, 3 (9.7%) septic @entity2 , and 1 (3.2%) exit-site infection. Multivariate logistic regression analysis showed a higher PICC-related infection rate with chemotherapy (odds ratio (OR) 7.2-confidence interval (CI) 95% [1.77-29.5]), auto/allograft (OR 5.9-CI 95% [1.2-29.2]), and anti-coagulant therapy (OR 2.2-95% [1.4-12]). CONCLUSION: Chemotherapy, auto/allograft, and anti-coagulant therapy are associated with an increased risk of developing PICC-related @entity1 . CLINICAL ADVANCE: Chemotherapy, auto/allograft, and anti-coagulant therapy are important predictors of PICC-associated @entity1 . A careful assessment of these risk factors may be important for future success in preventing PICC-related @entity1 .

title: Peripherally Inserted Central Catheter-Related Infections in a Cohort of Hospitalized Adult XXXX .

answer: @entity0


abstract: Effects of @entity5 on @entity2 healing were prospectively investigated for @entity4 . Although there were no significant differences in clinical outcomes, the presence of intravertebral cleft was related to the medication use. These results suggest that suspension of @entity5 use should be considered during the @entity2 healing period. INTRODUCTION: The purpose of this prospective study is to investigate whether @entity5 -based anti- @entity1 medication affects @entity2 healing and clinical outcomes of conservatively treated @entity4 ( @entity4 ). METHODS: A total of 105 @entity0 who were diagnosed with acute @entity4 were prospectively enrolled. According to their previous medication history, the @entity0 were allocated into group I (n   =   39, no history of @entity5 use) or group II (n   =   66, history of @entity5 use). Clinical outcomes were assessed using visual analogue scale (VAS), and @entity3 index (ODI). Radiographic parameters including changes in height loss and kyphotic angle at the index vertebra were measured, and radiographic findings suggesting impaired @entity2 healing such as the intravertebral cleft (IVC) sign and @entity2 instability were evaluated. Univariate and multivariate regression analyses were used to identify related factors. RESULTS: There were no significant differences in the last VAS and ODI between groups. There were also no significant differences in the radiographic parameters. Although the IVC sign was seen more commonly in group II (30.3  %) than in group I (20.5  %), @entity2 instability combined with IVC was noted in the same number of cases. On multiple regression analysis, medication history showed no significant relationship with the clinical parameters. However, the presence of the IVC sign was related to medication history (odds ratio 4.8; 95  % confidence interval [CI] 1.02-22.69). CONCLUSIONS: @entity5 use does not significantly affect the clinical results during conservative treatment for @entity4 . However, the occurrence of the IVC sign was related to medication history. Although further studies are needed to verify our findings, these results suggest that suspension of @entity5 use should be considered during the @entity2 healing period for acute @entity4 .

title: Does @entity5 -based anti- XXXX medication affect @entity4 healing?

answer: @entity1


abstract: Effects of @entity5 on @entity2 healing were prospectively investigated for @entity4 . Although there were no significant differences in clinical outcomes, the presence of intravertebral cleft was related to the medication use. These results suggest that suspension of @entity5 use should be considered during the @entity2 healing period. INTRODUCTION: The purpose of this prospective study is to investigate whether @entity5 -based anti- @entity1 medication affects @entity2 healing and clinical outcomes of conservatively treated @entity4 ( @entity4 ). METHODS: A total of 105 @entity0 who were diagnosed with acute @entity4 were prospectively enrolled. According to their previous medication history, the @entity0 were allocated into group I (n   =   39, no history of @entity5 use) or group II (n   =   66, history of @entity5 use). Clinical outcomes were assessed using visual analogue scale (VAS), and @entity3 index (ODI). Radiographic parameters including changes in height loss and kyphotic angle at the index vertebra were measured, and radiographic findings suggesting impaired @entity2 healing such as the intravertebral cleft (IVC) sign and @entity2 instability were evaluated. Univariate and multivariate regression analyses were used to identify related factors. RESULTS: There were no significant differences in the last VAS and ODI between groups. There were also no significant differences in the radiographic parameters. Although the IVC sign was seen more commonly in group II (30.3  %) than in group I (20.5  %), @entity2 instability combined with IVC was noted in the same number of cases. On multiple regression analysis, medication history showed no significant relationship with the clinical parameters. However, the presence of the IVC sign was related to medication history (odds ratio 4.8; 95  % confidence interval [CI] 1.02-22.69). CONCLUSIONS: @entity5 use does not significantly affect the clinical results during conservative treatment for @entity4 . However, the occurrence of the IVC sign was related to medication history. Although further studies are needed to verify our findings, these results suggest that suspension of @entity5 use should be considered during the @entity2 healing period for acute @entity4 .

title: Does XXXX -based anti- @entity1 medication affect @entity4 healing?

answer: @entity5


abstract: Effects of @entity5 on @entity2 healing were prospectively investigated for @entity4 . Although there were no significant differences in clinical outcomes, the presence of intravertebral cleft was related to the medication use. These results suggest that suspension of @entity5 use should be considered during the @entity2 healing period. INTRODUCTION: The purpose of this prospective study is to investigate whether @entity5 -based anti- @entity1 medication affects @entity2 healing and clinical outcomes of conservatively treated @entity4 ( @entity4 ). METHODS: A total of 105 @entity0 who were diagnosed with acute @entity4 were prospectively enrolled. According to their previous medication history, the @entity0 were allocated into group I (n   =   39, no history of @entity5 use) or group II (n   =   66, history of @entity5 use). Clinical outcomes were assessed using visual analogue scale (VAS), and @entity3 index (ODI). Radiographic parameters including changes in height loss and kyphotic angle at the index vertebra were measured, and radiographic findings suggesting impaired @entity2 healing such as the intravertebral cleft (IVC) sign and @entity2 instability were evaluated. Univariate and multivariate regression analyses were used to identify related factors. RESULTS: There were no significant differences in the last VAS and ODI between groups. There were also no significant differences in the radiographic parameters. Although the IVC sign was seen more commonly in group II (30.3  %) than in group I (20.5  %), @entity2 instability combined with IVC was noted in the same number of cases. On multiple regression analysis, medication history showed no significant relationship with the clinical parameters. However, the presence of the IVC sign was related to medication history (odds ratio 4.8; 95  % confidence interval [CI] 1.02-22.69). CONCLUSIONS: @entity5 use does not significantly affect the clinical results during conservative treatment for @entity4 . However, the occurrence of the IVC sign was related to medication history. Although further studies are needed to verify our findings, these results suggest that suspension of @entity5 use should be considered during the @entity2 healing period for acute @entity4 .

title: Does @entity5 -based anti- @entity1 medication affect XXXX healing?

answer: @entity4


abstract: Background. @entity1 survivors with @entity3 experience difficulty associated with their @entity2 . While much has been written about @entity3 's impacts on partners/family, we lack data regarding the psychosocial adjustment of @entity1 survivors, with a paucity of data from the @entity0 themselves. Methods. Qualitative study of lived experiences of individuals with @entity3 . Each of the @entity1 survivors with @entity3 completed 3-4 semistructured interviews. In most cases, @entity0 ' partners jointly participated in interviews, which were transcribed and analyzed using techniques derived from grounded theory. Results. 12 @entity0 were interviewed, with the total of 45 interviews over 18 months. Themes included poststroke changes in @entity0 ' relationships and identities, which were altered across several domains including occupational identity, relationship and family roles, and social identity. While all these domains were impacted by @entity3 , the impact varied over time. Conclusion. Despite the challenges of interviewing individuals with @entity3 , we explored @entity3 's impacts on how individuals experience their identity and develop new identities months and years after @entity1 . This data has important implications for primary care of @entity0 with @entity3 , including the importance of the long-term primary care relationship in supporting psychosocial adjustment to life after @entity1 .

title: Changes in identity after XXXX : implications for primary care.

answer: @entity1


abstract: @entity4 , primarily a @entity1 , is associated with a variety of serious problems due to @entity1 localization. @entity1 during surgery is difficult and total resection can rarely be achieved. Growth of the remaining @entity1 continues and symptoms of @entity3 , further @entity2 and hormonal disturbances reappear. However, conservative operation in conjunction with radical irradiation shows good results as regards @entity1 regression and survival with satisfactory quality of life. Irradiation with 50 Gy on average was performed in 5 out of 6 @entity0 with remaining @entity1 or @entity1 recurrence, and satisfactory results were obtained. In all cases @entity1 size regressed. Endocrine disturbances could be ascertained by the combined LHRH-TRH-insulin test and the clinical picture. In nearly every case there was finally a complete lack of hormones of the @entity5 . Substitution of various hormones became necessary in all cases. Meticulous surveillance of @entity0 still undergoing developmental maturation is mandatory. All six @entity0 are well and lead a nearly normal life.

title: [ XXXX : experience with combined operative and radiotherapy and problems of hormone substitution (author's transl)].

answer: @entity4


abstract: The @entity2 adrenal cortex is grossly composed of two regions: an outer, yellow zone and an inner, brown zone. These zones, which represent 33% and 66% of the total adrenocortical volume, respectively, can be separated by blunt dissection. It has been previously reported that specific @entity3 and @entity4 binding proteins are present in the high speed supernatant fraction (cytosol) prepared from the whole adrenal cortex of the @entity2 . However, when cytosol was prepared from the separate outer and inner cortical zones, it was found that the @entity0 -binding proteins were concentrated in the inner zone. This correlated with the level of @entity3 which was significantly greater in the cytosol of the inner zone where greater than 50% was found to be bound. In contrast, the concentration of @entity1 was 30 times greater in the cytosol of the outer cortical zone and less than 4% was found to be bound. These data suggest that @entity1 is produced primarily in the outer cortical zone, a region which comprises only one-third of the total cortical volume. On the other hand, the coexistence of @entity3 and its binding protein in the inner cortical zone, a region which comprises two-thirds or the greatest cortical volume, indicates a different functional status for this zone. The exact hormonal control of these two vastly different regions (chromatically, morphologically, and functionally) remains to be determined. It is speculated that the inner cortical zone of the adult @entity2 adrenal is the counterpart of the fetal cortex which did not involute.

title: Functional differences between the outer and inner zones of the XXXX adrenal cortex.

answer: @entity2


abstract: The places where a @entity0 lives and attends to school are both major environmental and social determinants of its present and future health status. @entity2 ( @entity2 ) and some of their risk factors among @entity0 and adolescent populations are @entity1 and @entity6 , so finding the patterns of distribution of these risk factors by gender, type of school, area, and margination level is important to do health intervention focusing in their necessities to prevent diseases at younger ages. Because of that, a cross-sectional study was performed among elementary and junior high school students from public and private schools in six of the seven areas of the metropolitan zone of San Luis Potosi, Mexico. Biochemical @entity6 indicators ( @entity5 , total @entity3 , and high-density lipoprotein) and anthropometric data (weight and height) were obtained. Seventeen public schools and five private schools with a total of 383 students were included. More than half of the studied population (53.0  %) had elevated @entity4 levels. A total of 330 students (86.2  %) had normal levels of total @entity3 with a mean value of 141.7  mg/dl, and 202 schoolchildren (52.8  %) had lower than acceptable levels of high-density lipoprotein (HDL) with a mean value of 43.9  mg/dl. There were differences in the levels of high-density protein between the areas and the type of school where they had been studied. Finally, a total of 150 students (39.4  %) had at least one altered lipid value and 103 @entity0 (26.9  %) had two altered values. Several students, despite their young age, showed a high prevalence of risk factors, so it is important to design programs according to their necessities.

title: Socio-Urban Spatial Patterns Associated with XXXX among Schoolchildren in the City of San Luis Potosi, Mexico.

answer: @entity6


abstract: BACKGROUND: Since @entity11 ( @entity11 ) appears to be a risk factor for @entity2 , the aim of the study was to determine the relationship between the size of @entity7 and inflammatory markers (hsCRP, @entity5 , @entity3 ), as well as lipids and lipoproteins ( @entity10 , @entity9 , @entity8 level) in blood serum of @entity0 with @entity11 . METHODS: The @entity0 studied (n   =   43) were divided into groups: @entity0 under 50 and over 50  years of age, and a separate subgroup of the oldest age with the largest size of @entity7 . @entity9 ( @entity9 ) above 150  mg/dL and below 150  mg/dL was used as an important criterion for the division of @entity0 into groups. The @entity7 size was measured using the Kodak digital imaging system software. The control group consisted of clinically healthy volunteers (n   =   20) without @entity11 . Lipids were measured on a Siemens analyzer (Germany), @entity9 , @entity8 , hsCRP levels were determined by immunonephelometric method, using the Health Care Diagnostic Product (Siemens GmbH, Germany), and @entity5 , @entity3 and LpPLAG7 assay kits (ELISA, R_D Systems) were used. RESULTS: The findings suggested that in @entity0 with @entity11 and their age increase, the @entity7 size, the concentration of inflammatory markers and @entity10 mass increased. Correlations between the @entity7 size and @entity10 mass and between the @entity7 size and TG level in @entity0 with @entity9 150    <=   mg/dL showed increase TG in atherogenic @entity8 -containing @entity4 -rich lipoprotein and TC in @entity1 -rich lipoprotein. The @entity0 with a low @entity9 and high @entity10 level can have a higher risk of odontogenic disease and progression of @entity6 and @entity2 . CONCLUSION: We have found a positive correlation between @entity9 level and the @entity7 size and a negative correlation between @entity10 level and the @entity7 size. The results suggest that @entity9 and @entity10 in HDL particles have antiinflammatory action and together can limit the @entity7 size in @entity0 with a higher @entity9 level. The literature data on the distribution of lipoprotein particles in subjects are still insufficient, so this problem requires further studies.

title: Lipids and lipoproteins and inflammatory markers in @entity0 with XXXX .

answer: @entity11


abstract: BACKGROUND: Since @entity11 ( @entity11 ) appears to be a risk factor for @entity2 , the aim of the study was to determine the relationship between the size of @entity7 and inflammatory markers (hsCRP, @entity5 , @entity3 ), as well as lipids and lipoproteins ( @entity10 , @entity9 , @entity8 level) in blood serum of @entity0 with @entity11 . METHODS: The @entity0 studied (n   =   43) were divided into groups: @entity0 under 50 and over 50  years of age, and a separate subgroup of the oldest age with the largest size of @entity7 . @entity9 ( @entity9 ) above 150  mg/dL and below 150  mg/dL was used as an important criterion for the division of @entity0 into groups. The @entity7 size was measured using the Kodak digital imaging system software. The control group consisted of clinically healthy volunteers (n   =   20) without @entity11 . Lipids were measured on a Siemens analyzer (Germany), @entity9 , @entity8 , hsCRP levels were determined by immunonephelometric method, using the Health Care Diagnostic Product (Siemens GmbH, Germany), and @entity5 , @entity3 and LpPLAG7 assay kits (ELISA, R_D Systems) were used. RESULTS: The findings suggested that in @entity0 with @entity11 and their age increase, the @entity7 size, the concentration of inflammatory markers and @entity10 mass increased. Correlations between the @entity7 size and @entity10 mass and between the @entity7 size and TG level in @entity0 with @entity9 150    <=   mg/dL showed increase TG in atherogenic @entity8 -containing @entity4 -rich lipoprotein and TC in @entity1 -rich lipoprotein. The @entity0 with a low @entity9 and high @entity10 level can have a higher risk of odontogenic disease and progression of @entity6 and @entity2 . CONCLUSION: We have found a positive correlation between @entity9 level and the @entity7 size and a negative correlation between @entity10 level and the @entity7 size. The results suggest that @entity9 and @entity10 in HDL particles have antiinflammatory action and together can limit the @entity7 size in @entity0 with a higher @entity9 level. The literature data on the distribution of lipoprotein particles in subjects are still insufficient, so this problem requires further studies.

title: Lipids and lipoproteins and inflammatory markers in XXXX with @entity11 .

answer: @entity0


abstract: Background/Aims. The aim of this study is to clarify the differences of @entity6 and @entity5 expression, chemokine correlated to intestinal homeostasis, between pediatric and adult @entity1 ( @entity1 ) @entity0 . Methods. Onehundred forty-one @entity0 who underwent proctocolectomy were divided to two groups including childhood-onset @entity1 (CUC, <16 years old, n = 24) and adult-onset @entity1 (AUC,    16 years old, n = 117). A total of 141 @entity2 -fixed, @entity3 -embedded tissue samples of rectum were obtained from these @entity0 . Histological inflammation of rectum in resected specimen was evaluated by using Geboes histological assessment. In immunohistochemistry study, the @entity6 expression was evaluated by intensity and the stained area, and the @entity5 expression was evaluated by lymphocytes infiltration pattern. Results. @entity6 score and @entity5 positive lymphocytes infiltration pattern were statistically significantly correlated with histological inflammation severity of @entity1 in all @entity0 (P < 0.05). @entity6 and @entity5 expression in CUC were statistically significantly higher than that in AUC in all or pathologically severe cases (P < 0.05). Conclusions. @entity6 and @entity5 may play a significant role in local damage and pathological changes in @entity1 especially pediatric @entity0 . In the future, our understanding of the differences in CCL- @entity5 interaction between adults and @entity0 may lead to the pathogenesis of @entity4 .

title: The Increased Expression of @entity6 and XXXX in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis.

answer: @entity5


abstract: Background/Aims. The aim of this study is to clarify the differences of @entity6 and @entity5 expression, chemokine correlated to intestinal homeostasis, between pediatric and adult @entity1 ( @entity1 ) @entity0 . Methods. Onehundred forty-one @entity0 who underwent proctocolectomy were divided to two groups including childhood-onset @entity1 (CUC, <16 years old, n = 24) and adult-onset @entity1 (AUC,    16 years old, n = 117). A total of 141 @entity2 -fixed, @entity3 -embedded tissue samples of rectum were obtained from these @entity0 . Histological inflammation of rectum in resected specimen was evaluated by using Geboes histological assessment. In immunohistochemistry study, the @entity6 expression was evaluated by intensity and the stained area, and the @entity5 expression was evaluated by lymphocytes infiltration pattern. Results. @entity6 score and @entity5 positive lymphocytes infiltration pattern were statistically significantly correlated with histological inflammation severity of @entity1 in all @entity0 (P < 0.05). @entity6 and @entity5 expression in CUC were statistically significantly higher than that in AUC in all or pathologically severe cases (P < 0.05). Conclusions. @entity6 and @entity5 may play a significant role in local damage and pathological changes in @entity1 especially pediatric @entity0 . In the future, our understanding of the differences in CCL- @entity5 interaction between adults and @entity0 may lead to the pathogenesis of @entity4 .

title: The Increased Expression of XXXX and @entity5 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis.

answer: @entity6


abstract: @entity10 ( @entity10 , @entity10 , or extramedullary @entity1 ) is an extramedullary mass forming @entity1 composed of myeloid precursor cells. It is usually associated with @entity11 but very rarely may precede the onset of @entity6 . Here, we are presenting a rare case of primary vaginal @entity10 in a geriatric female @entity0 without initial presentation of @entity8 ( @entity8 ). A 68-year-old female @entity0 with ECOG Performance Score of 1 presented with pervaginal @entity4 for 20 days. On colposcopic examination, she was found to have mass in the anterior fornix of vagina. A punch biopsy specimen revealed @entity13 . @entity12 ( @entity12 ), @entity9 ( @entity9 ), and @entity7 were strongly positive on IHC (immunohistochemistry). The @entity0 's routine blood investigations were normal including peripheral smear, @entity5 dehydrogenase, @entity3 , 2D echocardiography, conventional cytogenetics, @entity2 , and biopsy. The @entity0 was given 4 cycles of @entity14 (Decitex, manufactured by Sun Pharmaceutical Industries Limited, India), 20   mg/m(2) for 5 days at an interval of 28 days. There was a partial response to @entity14 according to RECIST criteria. As @entity14 therapy was well tolerated, we are continuing in the same way until disease progression without any complications. The @entity0 is undergoing regular follow-up at our centre.

title: XXXX : a rare case report and review of the literature.

answer: @entity10


abstract: @entity2 is extremely rare, with less than 10 cases reported in the literature. We report a case of small bowel dissemination of @entity8 in a 21-year-old African American male with a history of living in San Joaquin Valley. The @entity0 presented with one week of @entity4 , @entity3 , @entity6 , intermittent fever, and sweat, and one month of @entity7 . A chest radiograph revealed complete effusion of left lung. A computed tomography scan of the abdomen showed diffuse small bowel thickening and enhancement, as well as omental and peritoneal nodules, and @entity5 . The coccidioidal complement fixation titer was 1   :   256. The duodenal biopsy revealed many spherules filled with round fungal endospores. Later, blood fungal culture showed positivity for @entity9 . The final diagnosis is disseminated @entity8 involving lungs, blood, and duodenum. Despite aggressive antifungal therapy, the @entity0 's clinical situation deteriorated and he succumbed to multisystem organ failure one and half months later. A high index of suspicion for @entity2 should be maintained in @entity0 from an endemic area presenting as @entity7 and @entity1 .

title: Small bowel dissemination of XXXX .

answer: @entity8


abstract: UNASSIGNED: The incidence and mortality of invasive @entity1 (IPA) are rising, particularly in @entity4 @entity0 and @entity0 with severe @entity2 ( @entity2 ). Noninvasive @entity3 occurring in these @entity0 requires special attention because of the possibility of developing subsequent IPA, given the poor health and worsened immune state of these @entity0 . We compared the performance of the Platelia galactomannan (GM) enzyme immunoassay in the bronchoalveolar lavage fluid (BALF) and serum. The sensitivity, and specificity of BALF-GM were 85.4% and 62.4%, and those of serum-GM were 67.9% and 93.5% at the cutoff index of 0.5. As the cutoff index increased, the specificity of BALF-GM detection was increased with the detriment of sensitivity. The area under the ROC curves was 0.817 (95% CI: 0.718-0.916) for BALF-GM and 0.819 (95% CI: 0.712-0.926) for serum-GM. The optimal cutoff index was 1.19 for BALF-GM, and the sensitivity and specificity were 67.9% and 89.2%. The BALF-GM assay is more sensitive in detecting @entity1 than serum-GM assay and fungal cultures. However, BALF-GM assay has a high false-positive rate at the cutoff index of 0.5. Hence, the diagnostic cutoff index of the BALF-GM assay should be improved to avoid the overdiagnosis of @entity1 in clinic.

title: The Diagnosis of Invasive and Noninvasive XXXX by Serum and Bronchoalveolar Lavage Fluid Galactomannan Assay.

answer: @entity1


abstract: UNASSIGNED: A 42-year-old @entity0 presenting with complaints of squint for last 20 years. His visual acuity was 20/400 in right eye (RE) and 20/30 in left eye (LE) with glasses. His refraction was RE -16.75/-2.5 D cycl 180 and LE was -14.5/-1.5 D cycl 180. His axial length was 31.23 mm In RE and 29.72 mm in LE. On examination we found he had RE large @entity2 with hypotropia measuring 130 pd base out and 40 pd base up in RE. A computerized tomography scan revealed that the superior rectus (SR) was shifted nasally, and lateral rectus (LR) was shifted inferiorly. A RE medial rectus (MR) recession and LR resection with muscle transplantation on the MR was done. A loop myopexy was done to correct the path of the LR and SR. The @entity0 had only 18 pd eso and 20 pd hypo on follow-up after 3 months. Loop myopexy in conjunction with muscle transplantation is a safe and effective procedure for large angle @entity2 associated with @entity1 .

title: Loop myopexy with true muscle transplantation for very large angle XXXX @entity0 .

answer: @entity1


abstract: UNASSIGNED: A 42-year-old @entity0 presenting with complaints of squint for last 20 years. His visual acuity was 20/400 in right eye (RE) and 20/30 in left eye (LE) with glasses. His refraction was RE -16.75/-2.5 D cycl 180 and LE was -14.5/-1.5 D cycl 180. His axial length was 31.23 mm In RE and 29.72 mm in LE. On examination we found he had RE large @entity2 with hypotropia measuring 130 pd base out and 40 pd base up in RE. A computerized tomography scan revealed that the superior rectus (SR) was shifted nasally, and lateral rectus (LR) was shifted inferiorly. A RE medial rectus (MR) recession and LR resection with muscle transplantation on the MR was done. A loop myopexy was done to correct the path of the LR and SR. The @entity0 had only 18 pd eso and 20 pd hypo on follow-up after 3 months. Loop myopexy in conjunction with muscle transplantation is a safe and effective procedure for large angle @entity2 associated with @entity1 .

title: Loop myopexy with true muscle transplantation for very large angle @entity1 XXXX .

answer: @entity0


abstract: UNASSIGNED: The reproductive performance of @entity0 is one of the main determinants of the profit farmers make from @entity0 production. This study was undertaken to describe whether periods of high environmental temperature have an effect on the farrowing rate, litter sizes and number of @entity1 in commercial breeding units in South Africa. Data were collected weekly from four commercial breeding units with good records from December 2010 to August 2012. These data included the number of sows mated, number of sows farrowed and number of piglets born alive, as well as the number of @entity1 . Note was also taken of whether environmental temperature control mechanisms were employed. Temperature data from weather stations within 100 km of the breeding units were obtained from the South African Weather Service. In all breeding units a decrease in farrowing rate following mating during severe average temperatures (> 30   C) when compared to the farrowing rate following mating during mild average temperatures (< 22   C) was observed. When mating occurred at higher temperatures, the resultant litter size was marginally decreased in the breeding units that did not employ environmental temperature control, but was unaffected in the breeding units that did. In all four breeding units the trend was for the average number of piglets born alive to increase as the environmental temperature around the time of farrowing increased and the trend in three of the four breeding units was for the percentage of @entity1 per litter to decrease with increased temperature around the time of farrowing. The most significant observation in this study was the trend for farrowing rates to decrease following inseminations during times of high ambient temperatures (> 30   C). Environmental temperature control did not negate this effect, but the breeding units employing the environmental temperature control did show higher average farrowing rates overall.

title: The influence of environmental temperatures on farrowing rates and litter sizes in South African XXXX breeding units.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: To study the significance of @entity5 as a prognostic marker for acute @entity2 @entity3 @entity0 undergoing revascularization treatment after @entity6 . METHODS: @entity0 with @entity6 , who underwent intravenous and/or intra-arterial revascularization treatment, were enrolled. Intracranial @entity5 scores were calculated by counting calcified intracranial arteries among major seven arteries on computed tomographic angiography. @entity0 were divided into high ( @entity7 ; score >= 3) or low calcification burden (LCB; score <3) groups. Demographic, imaging, and outcome data were compared, and whether @entity7 is a prognostic factor was evaluated. Grave prognosis was defined as modified Rankin Scale 5-6 for this study. RESULTS: Of 80 enrolled @entity0 , the @entity7 group comprised 15 @entity0 , who were older, and more commonly had @entity1 than @entity0 in the LCB group. Initial National Institutes of Health @entity3 Scale (NIHSS) scores did not differ ( @entity7 13.3  2.7 vs. LCB 14.6  3.8) between groups. The final good reperfusion after revascularization treatment (thrombolysis in @entity4 score 2b-3, @entity7 66.7% vs. LCB 69.2%) was similarly achieved in both groups. However, the @entity7 group had significantly higher NIHSS scores at discharge (16.0  12.3 vs. 7.9  8.3), and more frequent grave outcome at 3 months (57.1% vs. 22.0%) than the LCB group. @entity7 was proven as an independent predictor for grave outcome at 3 months when several confounding factors were adjusted (odds ratio 4.135, 95% confidence interval, 1.045-16.359, P=0.043). CONCLUSIONS: Intracranial @entity7 was associated with grave prognosis in @entity0 who have undergone revascularization for @entity6 .

title: Cerebral XXXX is an imaging prognostic marker for revascularization treatment of @entity6 .

answer: @entity5


abstract: BACKGROUND AND PURPOSE: To study the significance of @entity5 as a prognostic marker for acute @entity2 @entity3 @entity0 undergoing revascularization treatment after @entity6 . METHODS: @entity0 with @entity6 , who underwent intravenous and/or intra-arterial revascularization treatment, were enrolled. Intracranial @entity5 scores were calculated by counting calcified intracranial arteries among major seven arteries on computed tomographic angiography. @entity0 were divided into high ( @entity7 ; score >= 3) or low calcification burden (LCB; score <3) groups. Demographic, imaging, and outcome data were compared, and whether @entity7 is a prognostic factor was evaluated. Grave prognosis was defined as modified Rankin Scale 5-6 for this study. RESULTS: Of 80 enrolled @entity0 , the @entity7 group comprised 15 @entity0 , who were older, and more commonly had @entity1 than @entity0 in the LCB group. Initial National Institutes of Health @entity3 Scale (NIHSS) scores did not differ ( @entity7 13.3  2.7 vs. LCB 14.6  3.8) between groups. The final good reperfusion after revascularization treatment (thrombolysis in @entity4 score 2b-3, @entity7 66.7% vs. LCB 69.2%) was similarly achieved in both groups. However, the @entity7 group had significantly higher NIHSS scores at discharge (16.0  12.3 vs. 7.9  8.3), and more frequent grave outcome at 3 months (57.1% vs. 22.0%) than the LCB group. @entity7 was proven as an independent predictor for grave outcome at 3 months when several confounding factors were adjusted (odds ratio 4.135, 95% confidence interval, 1.045-16.359, P=0.043). CONCLUSIONS: Intracranial @entity7 was associated with grave prognosis in @entity0 who have undergone revascularization for @entity6 .

title: Cerebral @entity5 is an imaging prognostic marker for revascularization treatment of XXXX .

answer: @entity6


abstract: UNASSIGNED: Endometriosis is a significant risk factor for clear cell and @entity2 and is often found contiguous with these @entity1 . Using whole-genome shotgun sequencing of seven @entity2 ( @entity2 ) and targeted sequencing in synchronous @entity3 , we have investigated how this @entity5 may evolve from @entity3 . In every case we observed multiple @entity1 -associated somatic mutations in at least one concurrent @entity4 . @entity7 and @entity6 mutations appeared consistently in concurrent @entity3 when present in the primary @entity2 . In several cases, one or more @entity4 carried the near-complete complement of somatic mutations present in the index @entity2 . Ancestral mutations were detected in both @entity1 -adjacent and -distant @entity4 , regardless of any cytological atypia. These findings provide objective evidence that multifocal benign @entity4 are clonally related and that CCCs arising in these @entity0 progress from @entity4 that may already carry sufficient @entity1 -associated mutations to be considered @entity1 themselves, albeit with low malignant potential. We speculate that genomically distinct classes of @entity3 exist and that @entity2 with high mutational burden represents one class at high risk for malignant transformation.    2015 The Authors. The Journal of Pathology published by John Wiley _ Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

title: Multifocal @entity4 associated with XXXX are clonal and carry a high mutation burden.

answer: @entity1


abstract: UNASSIGNED: Endometriosis is a significant risk factor for clear cell and @entity2 and is often found contiguous with these @entity1 . Using whole-genome shotgun sequencing of seven @entity2 ( @entity2 ) and targeted sequencing in synchronous @entity3 , we have investigated how this @entity5 may evolve from @entity3 . In every case we observed multiple @entity1 -associated somatic mutations in at least one concurrent @entity4 . @entity7 and @entity6 mutations appeared consistently in concurrent @entity3 when present in the primary @entity2 . In several cases, one or more @entity4 carried the near-complete complement of somatic mutations present in the index @entity2 . Ancestral mutations were detected in both @entity1 -adjacent and -distant @entity4 , regardless of any cytological atypia. These findings provide objective evidence that multifocal benign @entity4 are clonally related and that CCCs arising in these @entity0 progress from @entity4 that may already carry sufficient @entity1 -associated mutations to be considered @entity1 themselves, albeit with low malignant potential. We speculate that genomically distinct classes of @entity3 exist and that @entity2 with high mutational burden represents one class at high risk for malignant transformation.    2015 The Authors. The Journal of Pathology published by John Wiley _ Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

title: Multifocal XXXX associated with @entity1 are clonal and carry a high mutation burden.

answer: @entity4


abstract: Two groups of @entity1 received @entity2 (Amp). One group (AA) received a single acute dose of 1 mg/kg i.v. The second (CA) received 10 mg/kg i.p. daily for 4 days. In AA @entity1 , measurements 1 to 5 hr after Amp were compared with their own preinfusion values. Inulin clearance, (CIn, 4.5 ml X min-1 X kg-1 per kidney pre vs. 1.3 post), @entity0 ( @entity0 , 12.0 ml X min-1 X kg-1 vs. 7.4), and the estimated pressure in the glomerular capillaries ( @entity3 , 52 mm Hg vs. 40), were all significantly decreased while renal vascular resistance (5.2 mm Hg/ml vs. 12.0) was increased. Only 45% of the 3H-inulin injected into surface tubules was recovered in the urine as contrasted with 100% recovery before injection. This suggests that tubule permeability was increased, but there was no histologic evidence of @entity4 . Twenty-four hours after intravenous Amp, CIn and @entity0 returned to normal. Data from CA @entity1 were compared with values from sham-treated pairfed (PF) control @entity1 . Again, CIn (4.22 ml X min-1 X kg-1 in PF vs. 2.69 in CA), @entity0 (16.1 ml X min-1 X kg-1 vs. 8.3), and @entity3 (48 mm Hg vs. 38) were decreased, and renal vascular resistance (4.9 mm Hg/ml vs. 8.0) was increased. The recovery of 3H-inulin in the urine was slightly, but significantly, decreased (96% vs. 83%). These findings demonstrate that Amp decreases renal function by at least two mechanisms. An increase in renal vascular resistance is most important, although increased tubule permeability with a "backleak" of tubule fluid also contributes to @entity0 , particularly after intravenous Amp.

title: XXXX nephrotoxicity: increased renal resistance and tubule permeability.

answer: @entity2


abstract: PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) imaging characteristics of @entity2 in @entity0 with normal, fibrotic and cirrhotic livers. MATERIALS AND METHODS: Retrospective, institutional review board approved study (waiver of informed consent). Eighty-nine consecutive @entity0 with 231 @entity2 who underwent liver MR imaging for lesion characterization were included. Lesions were classified into three groups according to the @entity0 ' liver condition: no underlying @entity4 (group 1), @entity1 (group 2) and @entity1 (group 3). Qualitative and quantitative characteristics (number, size, signal intensities on T1-, T2-, and DW MR images, T2 shine-through effect, enhancement patterns (classical, rapidly filling, delayed filling), and ADC values) were compared. RESULTS: There were 160 (69%), 45 (20%), and 26 (11%) @entity5 in groups 1, 2 and 3, respectively. Lesions were larger in @entity0 with normal liver (group 1 vs. groups 2 and 3; P=.009). No difference was found between the groups on T2-weighted images (fat-suppressed fast spin-echo (P=.82) and single-shot (P=.25)) and in enhancement patterns (P=.56). Mean ADC values of @entity5 were similar between groups 1, 2 and 3 (2.11  .52*10(-3)mm(2)/s, 2.1  .53*10(-3)mm(2)/s and 2.14  .44*10(-3)mm(2)/s, P=87, respectively). T2 shine-through effect was less frequently observed in @entity1 (P=.02). CONCLUSION: MR imaging characteristics of @entity2 were similar in @entity0 with normal compared to fibrotic and cirrhotic livers. Smaller lesion size was observed with @entity4 and less T2 shine-through effect was seen in @entity5 developed on @entity1 , the latter being an important finding to highlight in these @entity0 at risk of developing @entity3 .

title: Is magnetic resonance imaging of XXXX any different in liver @entity1 and @entity1 compared to normal liver?

answer: @entity2


abstract: PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) imaging characteristics of @entity2 in @entity0 with normal, fibrotic and cirrhotic livers. MATERIALS AND METHODS: Retrospective, institutional review board approved study (waiver of informed consent). Eighty-nine consecutive @entity0 with 231 @entity2 who underwent liver MR imaging for lesion characterization were included. Lesions were classified into three groups according to the @entity0 ' liver condition: no underlying @entity4 (group 1), @entity1 (group 2) and @entity1 (group 3). Qualitative and quantitative characteristics (number, size, signal intensities on T1-, T2-, and DW MR images, T2 shine-through effect, enhancement patterns (classical, rapidly filling, delayed filling), and ADC values) were compared. RESULTS: There were 160 (69%), 45 (20%), and 26 (11%) @entity5 in groups 1, 2 and 3, respectively. Lesions were larger in @entity0 with normal liver (group 1 vs. groups 2 and 3; P=.009). No difference was found between the groups on T2-weighted images (fat-suppressed fast spin-echo (P=.82) and single-shot (P=.25)) and in enhancement patterns (P=.56). Mean ADC values of @entity5 were similar between groups 1, 2 and 3 (2.11  .52*10(-3)mm(2)/s, 2.1  .53*10(-3)mm(2)/s and 2.14  .44*10(-3)mm(2)/s, P=87, respectively). T2 shine-through effect was less frequently observed in @entity1 (P=.02). CONCLUSION: MR imaging characteristics of @entity2 were similar in @entity0 with normal compared to fibrotic and cirrhotic livers. Smaller lesion size was observed with @entity4 and less T2 shine-through effect was seen in @entity5 developed on @entity1 , the latter being an important finding to highlight in these @entity0 at risk of developing @entity3 .

title: Is magnetic resonance imaging of @entity2 any different in liver XXXX and @entity1 compared to normal liver?

answer: @entity1


abstract: PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) imaging characteristics of @entity2 in @entity0 with normal, fibrotic and cirrhotic livers. MATERIALS AND METHODS: Retrospective, institutional review board approved study (waiver of informed consent). Eighty-nine consecutive @entity0 with 231 @entity2 who underwent liver MR imaging for lesion characterization were included. Lesions were classified into three groups according to the @entity0 ' liver condition: no underlying @entity4 (group 1), @entity1 (group 2) and @entity1 (group 3). Qualitative and quantitative characteristics (number, size, signal intensities on T1-, T2-, and DW MR images, T2 shine-through effect, enhancement patterns (classical, rapidly filling, delayed filling), and ADC values) were compared. RESULTS: There were 160 (69%), 45 (20%), and 26 (11%) @entity5 in groups 1, 2 and 3, respectively. Lesions were larger in @entity0 with normal liver (group 1 vs. groups 2 and 3; P=.009). No difference was found between the groups on T2-weighted images (fat-suppressed fast spin-echo (P=.82) and single-shot (P=.25)) and in enhancement patterns (P=.56). Mean ADC values of @entity5 were similar between groups 1, 2 and 3 (2.11  .52*10(-3)mm(2)/s, 2.1  .53*10(-3)mm(2)/s and 2.14  .44*10(-3)mm(2)/s, P=87, respectively). T2 shine-through effect was less frequently observed in @entity1 (P=.02). CONCLUSION: MR imaging characteristics of @entity2 were similar in @entity0 with normal compared to fibrotic and cirrhotic livers. Smaller lesion size was observed with @entity4 and less T2 shine-through effect was seen in @entity5 developed on @entity1 , the latter being an important finding to highlight in these @entity0 at risk of developing @entity3 .

title: Is magnetic resonance imaging of @entity2 any different in liver @entity1 and XXXX compared to normal liver?

answer: @entity1


abstract: BACKGROUND: Eosinophilic @entity11 with @entity11 (EGPA) is a rare @entity13 associated with @entity6 , @entity9 , and @entity7 . EGPA is potentially life-threatening and often involves @entity10 , peptic ulcers, @entity12 , and @entity3 . However, there is limited understanding of the prognostics factors for @entity0 with EGPA. We investigated the clinical features and factors affecting @entity0 ' in-hospital mortality, using a national inpatient database in Japan. METHODS: We retrospectively collected data of EGPA @entity0 who required hospitalization between July 2010 and March 2013, using the Diagnosis Procedure Combination database. We evaluated EGPA @entity0 ' characteristics and performed multivariate logistic regression analyses to assess the factors associated with in-hospital mortality. RESULTS: A total of 2195 EGPA @entity0 were identified. The mean age was 61.9  years, 42.1% (924/2195) were male, and 41.6% (914/2195) had emergent admission. In-hospital deaths occurred in 97/2195 @entity0 (4.4%). Higher in-hospital mortality was associated with age older than 65  years, disturbance of consciousness on admission, unscheduled admission, @entity8 , @entity4 , @entity2 , @entity5 , and @entity1 on admission. Lower mortality was associated with female gender and @entity10 . CONCLUSIONS: Our study revealed the clinical features of EGPA @entity0 who required hospitalization and the factors associated with their mortality. These results may be useful for physicians when assessing disease severity or treatments for hospitalized EGPA @entity0 .

title: Factors that predict in-hospital mortality in eosinophilic XXXX with @entity11 .

answer: @entity11


abstract: BACKGROUND: Eosinophilic @entity11 with @entity11 (EGPA) is a rare @entity13 associated with @entity6 , @entity9 , and @entity7 . EGPA is potentially life-threatening and often involves @entity10 , peptic ulcers, @entity12 , and @entity3 . However, there is limited understanding of the prognostics factors for @entity0 with EGPA. We investigated the clinical features and factors affecting @entity0 ' in-hospital mortality, using a national inpatient database in Japan. METHODS: We retrospectively collected data of EGPA @entity0 who required hospitalization between July 2010 and March 2013, using the Diagnosis Procedure Combination database. We evaluated EGPA @entity0 ' characteristics and performed multivariate logistic regression analyses to assess the factors associated with in-hospital mortality. RESULTS: A total of 2195 EGPA @entity0 were identified. The mean age was 61.9  years, 42.1% (924/2195) were male, and 41.6% (914/2195) had emergent admission. In-hospital deaths occurred in 97/2195 @entity0 (4.4%). Higher in-hospital mortality was associated with age older than 65  years, disturbance of consciousness on admission, unscheduled admission, @entity8 , @entity4 , @entity2 , @entity5 , and @entity1 on admission. Lower mortality was associated with female gender and @entity10 . CONCLUSIONS: Our study revealed the clinical features of EGPA @entity0 who required hospitalization and the factors associated with their mortality. These results may be useful for physicians when assessing disease severity or treatments for hospitalized EGPA @entity0 .

title: Factors that predict in-hospital mortality in eosinophilic @entity11 with XXXX .

answer: @entity11


abstract: PURPOSE: To quantitatively analyze @entity5 ( @entity5 ) in @entity0 with primary @entity4 (PACG) and @entity2 ( @entity2 ), and to evaluate its correlation with severity of @entity3 . METHODS: In this retrospective study, records of @entity0 with previously diagnosed @entity2 or PACG at a tertiary @entity3 service were reviewed. @entity5 was measured by ultrasound pachymetry. @entity6 ( @entity6 ) on @entity1 ( @entity1 ) testing was recorded for @entity3 severity determination. @entity5 and age- and sex-adjusted @entity5 were compared among the study groups using Student's t-test and analysis of covariance (ANCOVA), respectively. Univariate and multivariate regression models were used for correlation of age, @entity6 and @entity5 . RESULTS: A total of 115 @entity0 with PACG, 215 with @entity2 , and 100 normal controls were included with mean age of 64.1    10.4, 59.9    10.5, and 62.04    10.80 years, respectively. @entity5 was thicker in PACG eyes (545.5    46.1  m) as compared to @entity2 eyes (531.7    37.3  m) and controls (531.0    38.3  m) even after age and gender adjustment (ANCOVA, P = 0.05). @entity5 was found to decrease with increasing age only in the @entity2 group (b = -0.57, P = 0.01). Disease severity ( @entity6 of @entity1 ) was significantly and inversely correlated with @entity5 in both @entity2 and PACG eyes (b = 1.89, P = 0.02; and b = 1.38, P = 0.04, respectively) after age and sex correction. CONCLUSION: PACG eyes had thicker @entity5 as compared to @entity2 and normal healthy eyes in Iranian subjects. Severity of the disease was inversely correlated with @entity5 in eyes with both @entity2 and PACG.

title: Central corneal thickness in primary angle closure and open XXXX .

answer: @entity3


abstract: BACKGROUND: India is currently suffering from an epidemic of noncommunicable diseases; it is thus imperative to screen for cardiovascular risk factors in @entity0 visiting Primary Health Centers (PHCs). The objective of the study was to measure the amount of undiagnosed @entity3 and selected cardiovascular risk factors present among the adult population through opportunistic screening at the PHC. METHODS: A facility-based opportunistic screening program was carried out in a PHC in rural Puducherry. @entity0 and accompanying @entity0 aged 30 years and above, who attended the daily outpatient department (OPD) were included. The OPD provides outpatient services and medical procedures or tests without requirement of an overnight stay, and functions for 4 h a day. Known @entity3 @entity0 and pregnant @entity0 were excluded. Information on age, gender, @entity1 status, and personal history of @entity4 and alcohol use were collected using an interview schedule. Height, weight and waist circumference were measured, along with blood pressure and blood sugar using standard protocols. Systolic blood pressure (SBP) >= 140 and/or diastolic blood pressure (DBP) >= 90 mm Hg was taken as @entity3 . SBP of 120-139 mm Hg and/or DBP of 80-89 mm Hg were taken as @entity6 . RESULTS: A total of 324 @entity0 were screened; 56.8% were females. The mean standard deviation (SD) age of the @entity0 was 47.7 (SD 12.6) years. @entity3 and @entity6 were present in 17.9% and 37.7% of the @entity0 respectively. 17.3% @entity0 had @entity1 . 22.2% and 21.3% of all @entity0 were current users of @entity4 and alcohol respectively. Generalized @entity2 was present in 31.8% of the @entity0 ; 19.1% were overweight. 45.1% @entity0 had @entity5 . CONCLUSIONS: A relatively large proportion of adults were found to have @entity6 and @entity2 , thus showing the need for early intervention.

title: Opportunistic Screening for XXXX and Selected Cardiovascular Risk Factors among Adults Attending a Primary Health Center in Puducherry, India.

answer: @entity3


abstract: The purpose was to test the hypothesis that the magnitude of the reduction in peak @entity1 uptake (VO2) after bed rest is directly proportional to the level of pre-bed rest peak VO2. Complete pre- and post-bed rest working capacity and body weight data were available from three studies involving 24 @entity0 (19-24 yr; peak VO2, 2.39-4.80 l . @entity2 ) and 8 @entity0 (23-34 yr; peak VO2 1.47-2.58 l . @entity2 ), who underwent bed rest for 14-20 d with no remedial treatments. Regression analysis of percent change in post-bed rest peak VO2 on pre-bed rest peak VO2 with 32 subjects resulted in correlation coefficients (r) of--0.03 (NS) for data expressed in l . @entity2 (NS) for data expressed in ml . @entity2 . kg-1. Significant correlations were found that supported the hypothesis only when peak VO2 data were analyzed separately from studies that utilized the cycle ergometer, particularly with subjects in the supine position, as opposed to data obtained from treadmill peak VO2 tests. We conclude that orthostatic factors, associated with the upright body position and relatively high levels of physical fitness from endurance training, appear to increase variability of pre- and particularly post-bed rest peak VO2 data, which would lead to rejection of the hypothesis.

title: Reduction in peak XXXX uptake after prolonged bed rest.

answer: @entity1


abstract: AIM: To systematically compare the efficacy and safety of off-label bevacizumab versus licensed ranibizumab intravitreal injections as well as monthly regimen versus pro re nata [PRN (as needed)] regimen in the treatment of neovascular age-related @entity4 (nAMD). METHODS: Relevant publications were identified through automatically retrieve of database and manually retrieving. The methodological quality of studies included was assessed using the Jadad score and the risk-of-bias assessment. The efficacy estimates were measured by the @entity1 ( @entity1 ) for the improvement of best-corrected visual acuity (BCVA) and central @entity3 . The safety estimates were measured by odds ratios (OR) for adverse events rates. Statistical analysis was conducted by Revman 5.2.7. RESULTS: Seven studies were included in the Meta-analysis. There were no statistically significant differences between bevacizumab and ranibizumab in BCVA at 1 and 2y (P=0.37, P=0.18, respectively), However, both drugs has better BCVA given monthly than given as needed at 1 and 2y (P<0.05). The results demonstrated the mean decrease in CRT was less in bevacizumab group than ranibizumab group at 1y (P<0.05), while the difference was not significant at 2y (P=0.24). Treatment monthly gained much more decrease in CRT at 1 and 2y (P<0.005). There were no differences between drugs in the rates of @entity0 , arterial @entity2 events and venous @entity2 events (P=0.41, P=0.55, P=0.10, respectively), while the rates of medical dictionary for regulatory activities (MedDAR) system organ class events and >= 1 systemic serious adverse events were higher in bevacizumab group than ranibizumab group (P<0.05). But the incidences of @entity0 , arterial @entity2 events, venous @entity2 events, MedDAR system organ class events as well as >= 1 systemic serious adverse events were not statistically different between both treatment regimens of monthly and as needed (P=0.14, P=0.76, P=0.73, P=0.12, P=0.11, respectively). CONCLUSION: Bevacizumab was equivalent to ranibizumab for BCVA, however bevacizumab tended to gain less decrease in CRT and had higher rates of serious adverse events. Compared with treatment as needed, treatment monthly showed superior efficacy in BCVA improvement and CRT reduction, while the rates of adverse events were similar in the two dosing regimens.

title: Bevacizumab versus ranibizumab for neovascular age-related XXXX : a Meta-analysis.

answer: @entity4


abstract: The relationship between dairy consumption and @entity1 resistance was ascertained in 272 middle-aged, nondiabetic @entity0 using a cross-sectional design. @entity0 kept 7-day, weighed food records to report their diets, including dairy intake. @entity1 resistance was assessed using the homeostatic model assessment (HOMA). The Bod Pod was used to measure body fat percentage, and accelerometry for 7 days was used to objectively index physical activity. Regression analysis was used to determine the extent to which mean HOMA levels differed across low, moderate, and high dairy intake categories. Results showed that @entity0 in the highest quartile of dairy consumption had significantly greater log-transformed HOMA values (0.41    0.53) than those in the middle-two quartiles (0.22    0.55) or the lowest quartile (0.19    0.58) (F = 6.90, P = 0.0091). The association remained significant after controlling for each potential confounder individually and all covariates simultaneously. Adjusting for differences in energy intake weakened the relationship most, but the association remained significant. Of the 11 potential confounders, only protein intake differed significantly across the dairy categories, with those consuming high dairy also consuming more total protein than their counterparts. Apparently, high dairy intake is a significant predictor of @entity1 resistance in middle-aged, nondiabetic @entity0 .

title: Dairy consumption and XXXX resistance: the role of body fat, physical activity, and energy intake.

answer: @entity1


abstract: OBJECTIVE: Effects of the long-term use of antiepileptic drugs (AEDs) on the brains of @entity0 with @entity2 have been previously reported. The aim of this study was to determine the rapid @entity1 induced by single-dose intravenous AED administration that rules out the potential effects of @entity2 . METHODS: Ten @entity4 were randomly divided into two groups and were intravenously administered a single dose of @entity3 (VPA) or @entity5 (LEV) at treatment dosages. Magnetic resonance imaging (MRI) data were recorded from every subject prior to AED administration and at 2h and 1 week after administration. Using optimized voxel-based morphometry (VBM) analysis, we measured changes in regional gray matter volume (GMV) and white matter volume (WMV) in each group over time following medication and directly compared the differences between the two groups. RESULTS: Both AEDs induced brain volume alterations at 2h after their administration, but these changes had reverted at 1 week. The VPA group exhibited increased GMV in the right geniculate nucleus and the right pulvinar, whereas the LEV group exhibited WMV reductions in the right pulvinar, the right parietal lobe and the right occipital lobe. Directly compared with the LEV group, the VPA group exhibited a temporally constant GMV increase in the bilateral temporal cortex and a WMV reduction in the left pedunculus cerebri. CONCLUSIONS: Single-dose intravenous administration of a level of VPA or LEV that mimics clinical use is associated with rapid and reversible VBM-detected GMV or WMV alterations in @entity4 . This finding may provide new insights into the understanding of AED-induced @entity1 and may contribute to our understanding of the brain-level mechanisms and targets of AED action.

title: Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of XXXX and @entity5 in @entity4 .

answer: @entity3


abstract: OBJECTIVE: Effects of the long-term use of antiepileptic drugs (AEDs) on the brains of @entity0 with @entity2 have been previously reported. The aim of this study was to determine the rapid @entity1 induced by single-dose intravenous AED administration that rules out the potential effects of @entity2 . METHODS: Ten @entity4 were randomly divided into two groups and were intravenously administered a single dose of @entity3 (VPA) or @entity5 (LEV) at treatment dosages. Magnetic resonance imaging (MRI) data were recorded from every subject prior to AED administration and at 2h and 1 week after administration. Using optimized voxel-based morphometry (VBM) analysis, we measured changes in regional gray matter volume (GMV) and white matter volume (WMV) in each group over time following medication and directly compared the differences between the two groups. RESULTS: Both AEDs induced brain volume alterations at 2h after their administration, but these changes had reverted at 1 week. The VPA group exhibited increased GMV in the right geniculate nucleus and the right pulvinar, whereas the LEV group exhibited WMV reductions in the right pulvinar, the right parietal lobe and the right occipital lobe. Directly compared with the LEV group, the VPA group exhibited a temporally constant GMV increase in the bilateral temporal cortex and a WMV reduction in the left pedunculus cerebri. CONCLUSIONS: Single-dose intravenous administration of a level of VPA or LEV that mimics clinical use is associated with rapid and reversible VBM-detected GMV or WMV alterations in @entity4 . This finding may provide new insights into the understanding of AED-induced @entity1 and may contribute to our understanding of the brain-level mechanisms and targets of AED action.

title: Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of @entity3 and XXXX in @entity4 .

answer: @entity5


abstract: OBJECTIVE: Effects of the long-term use of antiepileptic drugs (AEDs) on the brains of @entity0 with @entity2 have been previously reported. The aim of this study was to determine the rapid @entity1 induced by single-dose intravenous AED administration that rules out the potential effects of @entity2 . METHODS: Ten @entity4 were randomly divided into two groups and were intravenously administered a single dose of @entity3 (VPA) or @entity5 (LEV) at treatment dosages. Magnetic resonance imaging (MRI) data were recorded from every subject prior to AED administration and at 2h and 1 week after administration. Using optimized voxel-based morphometry (VBM) analysis, we measured changes in regional gray matter volume (GMV) and white matter volume (WMV) in each group over time following medication and directly compared the differences between the two groups. RESULTS: Both AEDs induced brain volume alterations at 2h after their administration, but these changes had reverted at 1 week. The VPA group exhibited increased GMV in the right geniculate nucleus and the right pulvinar, whereas the LEV group exhibited WMV reductions in the right pulvinar, the right parietal lobe and the right occipital lobe. Directly compared with the LEV group, the VPA group exhibited a temporally constant GMV increase in the bilateral temporal cortex and a WMV reduction in the left pedunculus cerebri. CONCLUSIONS: Single-dose intravenous administration of a level of VPA or LEV that mimics clinical use is associated with rapid and reversible VBM-detected GMV or WMV alterations in @entity4 . This finding may provide new insights into the understanding of AED-induced @entity1 and may contribute to our understanding of the brain-level mechanisms and targets of AED action.

title: Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of @entity3 and @entity5 in XXXX .

answer: @entity4


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity2 ( @entity2 ) for @entity1 control in @entity0 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity0 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity0 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity4 - @entity3 cream application, (3) @entity2 and (4) @entity2 + intrarectal @entity4 - @entity3 cream application (combined group). @entity0 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity1 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity2 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity2 , @entity4 - @entity3 cream and combined groups compared to the control group (P < .001). In addition, the @entity2 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity2 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity2 alone seemed to be superior to @entity4 - @entity3 cream application in @entity0 undergoing prostate biopsy. Addition of @entity4 - @entity3 cream application to @entity2 may not provide better analgesia._

title: Novel Approach for @entity1 Control in @entity0 Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of @entity4 - XXXX : A Randomized Controlled Trial.

answer: @entity3


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity2 ( @entity2 ) for @entity1 control in @entity0 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity0 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity0 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity4 - @entity3 cream application, (3) @entity2 and (4) @entity2 + intrarectal @entity4 - @entity3 cream application (combined group). @entity0 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity1 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity2 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity2 , @entity4 - @entity3 cream and combined groups compared to the control group (P < .001). In addition, the @entity2 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity2 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity2 alone seemed to be superior to @entity4 - @entity3 cream application in @entity0 undergoing prostate biopsy. Addition of @entity4 - @entity3 cream application to @entity2 may not provide better analgesia._

title: Novel Approach for @entity1 Control in @entity0 Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of XXXX - @entity3 : A Randomized Controlled Trial.

answer: @entity4


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity2 ( @entity2 ) for @entity1 control in @entity0 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity0 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity0 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity4 - @entity3 cream application, (3) @entity2 and (4) @entity2 + intrarectal @entity4 - @entity3 cream application (combined group). @entity0 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity1 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity2 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity2 , @entity4 - @entity3 cream and combined groups compared to the control group (P < .001). In addition, the @entity2 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity2 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity2 alone seemed to be superior to @entity4 - @entity3 cream application in @entity0 undergoing prostate biopsy. Addition of @entity4 - @entity3 cream application to @entity2 may not provide better analgesia._

title: Novel Approach for XXXX Control in @entity0 Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of @entity4 - @entity3 : A Randomized Controlled Trial.

answer: @entity1


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity2 ( @entity2 ) for @entity1 control in @entity0 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity0 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity0 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity4 - @entity3 cream application, (3) @entity2 and (4) @entity2 + intrarectal @entity4 - @entity3 cream application (combined group). @entity0 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity1 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity2 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity2 , @entity4 - @entity3 cream and combined groups compared to the control group (P < .001). In addition, the @entity2 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity2 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity2 alone seemed to be superior to @entity4 - @entity3 cream application in @entity0 undergoing prostate biopsy. Addition of @entity4 - @entity3 cream application to @entity2 may not provide better analgesia._

title: Novel Approach for @entity1 Control in XXXX Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of @entity4 - @entity3 : A Randomized Controlled Trial.

answer: @entity0