abstract: OBJECTIVE: To study the effect of @entity8 on vascular biomarkers and carotid @entity2 ( @entity2 ) in @entity5 ( @entity5 ). METHODS: @entity5 @entity0 with inactive disease and subclinical @entity4 were randomized in a double-blinded manner to receive either @entity8 (10 mg/day) or matching placebo (half in each group were also randomly allocated low-dose @entity1 ). After 12 months, treatment was unblinded. @entity0 treated with @entity8 and @entity1 were continued on the same medications for another 12 months. Plasma levels of @entity6 , high-sensitivity C-reactive protein (hsCRP), soluble @entity7 , @entity9 , and thrombomodulin were measured at baseline, 6 months, and 12 months. Measurement of carotid @entity2 was repeated at 24 months. RESULTS: Seventy-two @entity0 were studied (97% @entity0 , mean    SD age 50.8    9.7 years). Thirty-six @entity0 were randomly assigned to each of the study arms (18 @entity0 in each arm also received @entity1 ). Baseline clinical characteristics and medications were similar between the two groups. At 12 months, the mean low-density lipoprotein @entity3 (mean    SD 2.62    1.04 mmoles/liter to 1.69    0.72 mmoles/liter; P < 0.001) and median hsCRP levels (1.26 mg/liter, interquartile range [IQR] 2.3 to 0.88 mg/liter, IQR 1.1; P = 0.02) decreased significantly in the @entity8 group. There was no significant change in @entity6 , and @entity1 use did not influence the levels of the biomarkers studied. A subgroup analysis of @entity0 with a @entity5 Activity Index score  <=2 revealed a significant decrease in hsCRP (1.20 mg/liter, IQR 2.3 to 0.92 mg/liter, IQR 1.1; P = 0.04) and thrombomodulin levels (0.76 ng/ml, IQR 1.2 to 0.67 ng/ml, IQR 1.0; P = 0.001) with @entity8 treatment. At 24 months, the @entity2 of the internal carotid arteries appeared to be decreased in @entity0 treated with @entity8 , which was well tolerated. CONCLUSION: In stable @entity5 @entity0 , low-dose @entity8 leads to a significant reduction in hsCRP and thrombomodulin levels, which may possibly help to reduce cardiovascular risk.

title: Effects of XXXX on vascular biomarkers and carotid atherosclerosis in lupus: a randomized, double-blind, placebo-controlled trial.

answer: @entity8


abstract: UNASSIGNED: Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of @entity0 @entity6 ( @entity6 ). @entity7 (-/-) @entity0 were implanted with saline- or @entity8 ( @entity8 )-filled miniosmotic pumps then treated with either the autophagy inhibitor @entity4 (CQ; 50 mg  (kg body mass)(-1)  day(-1), by intraperitoneal injection) or saline. @entity8 -elicited aneurysmal expansion of the suprarenal aorta coupled with @entity5 formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for @entity8 compared with 46.2% for @entity8 + CQ; P = NS) and categorical distribution of @entity2 . The markedly reduced survival rate observed with @entity8 (57.1% for @entity8 compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for @entity8 + CQ; P = NS compared with @entity8 ). CQ did not affect the mean maximum suprarenal aortic diameter (1.91    0.19 mm for @entity8 compared with 1.97    0.21 mm for @entity8 + CQ; P = NS). @entity9 fragmentation, collagen accumulation, and smooth @entity1 , which were higher in @entity8 -treated @entity0 , were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental @entity6 , suggesting that global loss of autophagy is unlikely to be a causal factor in the development of @entity3 . Manipulation of autophagy as a mechanism to reduce @entity6 may need re-evaluation.

title: Effects of long-term XXXX administration on the natural history of @entity3 in @entity0 .

answer: @entity4


abstract: UNASSIGNED: Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of @entity0 @entity6 ( @entity6 ). @entity7 (-/-) @entity0 were implanted with saline- or @entity8 ( @entity8 )-filled miniosmotic pumps then treated with either the autophagy inhibitor @entity4 (CQ; 50 mg  (kg body mass)(-1)  day(-1), by intraperitoneal injection) or saline. @entity8 -elicited aneurysmal expansion of the suprarenal aorta coupled with @entity5 formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for @entity8 compared with 46.2% for @entity8 + CQ; P = NS) and categorical distribution of @entity2 . The markedly reduced survival rate observed with @entity8 (57.1% for @entity8 compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for @entity8 + CQ; P = NS compared with @entity8 ). CQ did not affect the mean maximum suprarenal aortic diameter (1.91    0.19 mm for @entity8 compared with 1.97    0.21 mm for @entity8 + CQ; P = NS). @entity9 fragmentation, collagen accumulation, and smooth @entity1 , which were higher in @entity8 -treated @entity0 , were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental @entity6 , suggesting that global loss of autophagy is unlikely to be a causal factor in the development of @entity3 . Manipulation of autophagy as a mechanism to reduce @entity6 may need re-evaluation.

title: Effects of long-term @entity4 administration on the natural history of XXXX in @entity0 .

answer: @entity3


abstract: UNASSIGNED: Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of @entity0 @entity6 ( @entity6 ). @entity7 (-/-) @entity0 were implanted with saline- or @entity8 ( @entity8 )-filled miniosmotic pumps then treated with either the autophagy inhibitor @entity4 (CQ; 50 mg  (kg body mass)(-1)  day(-1), by intraperitoneal injection) or saline. @entity8 -elicited aneurysmal expansion of the suprarenal aorta coupled with @entity5 formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for @entity8 compared with 46.2% for @entity8 + CQ; P = NS) and categorical distribution of @entity2 . The markedly reduced survival rate observed with @entity8 (57.1% for @entity8 compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for @entity8 + CQ; P = NS compared with @entity8 ). CQ did not affect the mean maximum suprarenal aortic diameter (1.91    0.19 mm for @entity8 compared with 1.97    0.21 mm for @entity8 + CQ; P = NS). @entity9 fragmentation, collagen accumulation, and smooth @entity1 , which were higher in @entity8 -treated @entity0 , were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental @entity6 , suggesting that global loss of autophagy is unlikely to be a causal factor in the development of @entity3 . Manipulation of autophagy as a mechanism to reduce @entity6 may need re-evaluation.

title: Effects of long-term @entity4 administration on the natural history of @entity3 in XXXX .

answer: @entity0


abstract: An in vitro model of @entity8 was developed to study the pathophysiology of posttraumatic @entity3 . A 25 mm length of thoracic spinal cord was removed from the adult male @entity1 (n = 27). A dorsal column segment was isolated and pinned in a recording chamber and superfused with oxygenated (95% O2/5% @entity5 ) Ringer. The cord was stimulated with a bipolar electrode, while two point responses were recorded extracellularly. Injury was accomplished by compression with a modified @entity4 which applied a 2 g force for 15 s. With injury the compound action potential (CAP) amplitude decreased to 53.7 +/- 5.4% (P < 0.001), while the latency increased to 115.6 +/- 3.1% (P < 0.0025) of control values. The absolute refractory period increased with injury from 1.7 +/- 0.1 ms to 2.1 +/- 0.1 ms (P < 0.05). The infusion of 5 mM @entity6 ( @entity7 ), a blocker of voltage-sensitive 'fast' K channels confined to internodal regions, resulted in broadening of the CAP of injured axons to 114.9 +/- 3.1% of control (P < 0.05). Ultrastructural analysis of the injured dorsal column segments revealed marked axonal and myelin pathology, including considerable myelin disruption. In conclusion, we have developed and characterized an in vitro model of @entity0 @entity8 which simulates many of the features of in vivo @entity2 . Injured axons display characteristic changes in physiological function including a shift in refractory period and high frequency conduction failure. The ultrastructural data and response of injured axons to 4-AP suggest that myelin disruption with exposure of 'fast' K+ channels contributes to posttraumatic @entity3 .

title: XXXX in an in vitro model of acute compressive injury to adult @entity1 spinal cord axons.

answer: @entity3


abstract: An in vitro model of @entity8 was developed to study the pathophysiology of posttraumatic @entity3 . A 25 mm length of thoracic spinal cord was removed from the adult male @entity1 (n = 27). A dorsal column segment was isolated and pinned in a recording chamber and superfused with oxygenated (95% O2/5% @entity5 ) Ringer. The cord was stimulated with a bipolar electrode, while two point responses were recorded extracellularly. Injury was accomplished by compression with a modified @entity4 which applied a 2 g force for 15 s. With injury the compound action potential (CAP) amplitude decreased to 53.7 +/- 5.4% (P < 0.001), while the latency increased to 115.6 +/- 3.1% (P < 0.0025) of control values. The absolute refractory period increased with injury from 1.7 +/- 0.1 ms to 2.1 +/- 0.1 ms (P < 0.05). The infusion of 5 mM @entity6 ( @entity7 ), a blocker of voltage-sensitive 'fast' K channels confined to internodal regions, resulted in broadening of the CAP of injured axons to 114.9 +/- 3.1% of control (P < 0.05). Ultrastructural analysis of the injured dorsal column segments revealed marked axonal and myelin pathology, including considerable myelin disruption. In conclusion, we have developed and characterized an in vitro model of @entity0 @entity8 which simulates many of the features of in vivo @entity2 . Injured axons display characteristic changes in physiological function including a shift in refractory period and high frequency conduction failure. The ultrastructural data and response of injured axons to 4-AP suggest that myelin disruption with exposure of 'fast' K+ channels contributes to posttraumatic @entity3 .

title: @entity3 in an in vitro model of acute compressive injury to adult XXXX spinal cord axons.

answer: @entity1


abstract: @entity4 are a heterogenous group of @entity1 that show variable histologies, @entity3 and clinical outcomes. The idea of rigid distinctions between @entity1 types is appealing to pathologists, gynecologists, researchers and @entity0 , but in a recent study where high grade @entity4 were reviewed by three experienced gynecologic pathologists, diagnostic agreement about @entity1 type was reached in only approximately one half of cases. In general, biologically and clinically validated diagnostic criteria are lacking for high grade @entity4 and for those that appear mixed epithelial. Until such criteria are developed, it remains important to define which morphologic patterns convey accurate clinical and biological information and which do not or might not. " @entity4 with ambiguous features," the focus of this review, are @entity1 with comparatively uninformative morphologic features. Some publications indicate that gland forming and @entity4 that appear morphologically low grade or ambiguous are really high grade. There are also indications that high grade @entity4 are biologically heterogeneous and that the morphologic clues we currently use to distinguish one subtype from another fail to correlate with biological data. Many @entity1 that appear morphologically mixed are, in fact, not biologically or clinically confused: most represent biologically "pure" @entity1 with variant morphology. Interesting associations between the presence of @entity6 ( @entity2 ) and ambiguous morphology have been discussed in the literature. An apparent relationship between morphologic ambiguity and malignant mixed @entity1 ( @entity5 ) also exists. The identity of some morphologically ambiguous @entity4 can be elucidated with immunohistochemistry or other ancillary techniques at present, but the nature of many still remains undefined. This review presents the concept of morphologically ambiguous @entity4 , proposes morphological gold standard diagnostic criteria for @entity1 that are not ambiguous (an effort that helps define @entity1 that are ambiguous), provides a relevant literature review and offers practical guidance for sorting through diagnostically challenging cases.

title: XXXX with ambiguous features.

answer: @entity4


abstract: INTRODUCTION: @entity2 ( @entity2 ) has been reported to occur in @entity0 with @entity9 . In both conditions there is evidence to suggest disordered cerebral autoregulation. OBJECTIVES: We sought to investigate the concurrence of @entity2 with @entity9 and to describe the associated obstetric, radiologic and critical care correlates. METHODS: Single center 2001-2010 retrospective cohort study of all @entity0 with @entity9 who underwent neuroimaging via magnetic resonance imaging (MRI) or computerized tomography (CT) with or without contrast. The medical records of all @entity0 with @entity9 during the study interval were identified, evaluated and extracted for pertinent data; a diagnosis of @entity2 was made by radiologists using standard criteria. RESULTS: Forty-six of forty-seven (97.9%) @entity0 with @entity9 revealed @entity2 on neuroimaging using one or more modalities: MRI without contrast=41 (87.2%), MRI with contrast=27 (57.4%), CT without contrast=16 (34%), CT with contrast=7 (14.8%) and/or MRA/ @entity10 (4.3%). @entity2 was identified within the parietal (36, 78.3%), occipital (35, 76.1%), frontal (29, 63%), temporal (13, 28.3%) and basal ganglia/ brainstem/cerebellum (12, 26.1%). @entity9 occurred antepartum in 23 @entity0 , postpartum in 24 @entity0 with 22 vaginal/25 cesarean deliveries at a mean maternal age of 21.8 years (range 15-39) and a mean gestational age of 33.9 weeks (range 22.4-41.7 weeks). Ethnicity was African-American in 38 @entity0 . @entity1 was the most common presenting symptom (87.2%) followed by @entity6 (51.1%), @entity4 (34%) and @entity7 (19.1%). Severe systolic @entity3 was present in 22 (47%) of @entity0 .Use of antihypertensives (87%), @entity8 (100%), diuretics (66%) and @entity5 (50%) facilitated maternal recovery in all cases with usually a brief hospitalization (mean 3.9 days, range 1-20 days). CONCLUSION: The common finding of @entity2 in @entity0 with @entity9 suggests that @entity2 may be part of the pathogenesis of @entity9 . We speculate that therapy targeted at prevention or reversal of @entity2 pathogenesis will prevent or facilitate recovery from @entity9 .

title: PP137. @entity2 ( @entity2 ) is a constant component of XXXX .

answer: @entity9


abstract: INTRODUCTION: @entity2 ( @entity2 ) has been reported to occur in @entity0 with @entity9 . In both conditions there is evidence to suggest disordered cerebral autoregulation. OBJECTIVES: We sought to investigate the concurrence of @entity2 with @entity9 and to describe the associated obstetric, radiologic and critical care correlates. METHODS: Single center 2001-2010 retrospective cohort study of all @entity0 with @entity9 who underwent neuroimaging via magnetic resonance imaging (MRI) or computerized tomography (CT) with or without contrast. The medical records of all @entity0 with @entity9 during the study interval were identified, evaluated and extracted for pertinent data; a diagnosis of @entity2 was made by radiologists using standard criteria. RESULTS: Forty-six of forty-seven (97.9%) @entity0 with @entity9 revealed @entity2 on neuroimaging using one or more modalities: MRI without contrast=41 (87.2%), MRI with contrast=27 (57.4%), CT without contrast=16 (34%), CT with contrast=7 (14.8%) and/or MRA/ @entity10 (4.3%). @entity2 was identified within the parietal (36, 78.3%), occipital (35, 76.1%), frontal (29, 63%), temporal (13, 28.3%) and basal ganglia/ brainstem/cerebellum (12, 26.1%). @entity9 occurred antepartum in 23 @entity0 , postpartum in 24 @entity0 with 22 vaginal/25 cesarean deliveries at a mean maternal age of 21.8 years (range 15-39) and a mean gestational age of 33.9 weeks (range 22.4-41.7 weeks). Ethnicity was African-American in 38 @entity0 . @entity1 was the most common presenting symptom (87.2%) followed by @entity6 (51.1%), @entity4 (34%) and @entity7 (19.1%). Severe systolic @entity3 was present in 22 (47%) of @entity0 .Use of antihypertensives (87%), @entity8 (100%), diuretics (66%) and @entity5 (50%) facilitated maternal recovery in all cases with usually a brief hospitalization (mean 3.9 days, range 1-20 days). CONCLUSION: The common finding of @entity2 in @entity0 with @entity9 suggests that @entity2 may be part of the pathogenesis of @entity9 . We speculate that therapy targeted at prevention or reversal of @entity2 pathogenesis will prevent or facilitate recovery from @entity9 .

title: PP137. XXXX ( @entity2 ) is a constant component of @entity9 .

answer: @entity2


abstract: INTRODUCTION: @entity2 ( @entity2 ) has been reported to occur in @entity0 with @entity9 . In both conditions there is evidence to suggest disordered cerebral autoregulation. OBJECTIVES: We sought to investigate the concurrence of @entity2 with @entity9 and to describe the associated obstetric, radiologic and critical care correlates. METHODS: Single center 2001-2010 retrospective cohort study of all @entity0 with @entity9 who underwent neuroimaging via magnetic resonance imaging (MRI) or computerized tomography (CT) with or without contrast. The medical records of all @entity0 with @entity9 during the study interval were identified, evaluated and extracted for pertinent data; a diagnosis of @entity2 was made by radiologists using standard criteria. RESULTS: Forty-six of forty-seven (97.9%) @entity0 with @entity9 revealed @entity2 on neuroimaging using one or more modalities: MRI without contrast=41 (87.2%), MRI with contrast=27 (57.4%), CT without contrast=16 (34%), CT with contrast=7 (14.8%) and/or MRA/ @entity10 (4.3%). @entity2 was identified within the parietal (36, 78.3%), occipital (35, 76.1%), frontal (29, 63%), temporal (13, 28.3%) and basal ganglia/ brainstem/cerebellum (12, 26.1%). @entity9 occurred antepartum in 23 @entity0 , postpartum in 24 @entity0 with 22 vaginal/25 cesarean deliveries at a mean maternal age of 21.8 years (range 15-39) and a mean gestational age of 33.9 weeks (range 22.4-41.7 weeks). Ethnicity was African-American in 38 @entity0 . @entity1 was the most common presenting symptom (87.2%) followed by @entity6 (51.1%), @entity4 (34%) and @entity7 (19.1%). Severe systolic @entity3 was present in 22 (47%) of @entity0 .Use of antihypertensives (87%), @entity8 (100%), diuretics (66%) and @entity5 (50%) facilitated maternal recovery in all cases with usually a brief hospitalization (mean 3.9 days, range 1-20 days). CONCLUSION: The common finding of @entity2 in @entity0 with @entity9 suggests that @entity2 may be part of the pathogenesis of @entity9 . We speculate that therapy targeted at prevention or reversal of @entity2 pathogenesis will prevent or facilitate recovery from @entity9 .

title: PP137. @entity2 ( XXXX ) is a constant component of @entity9 .

answer: @entity2


abstract: INTRODUCTION: @entity6 is a major cause of maternal and perinatal morbidity and mortality in Brazil and worldwide. It is a heterogeneous and @entity2 , with no clear etiology and pathophysiology. The identification of risk factors for its development may help in prevention and early diagnosis of disease clinical onset. OBJECTIVES: To identify risk factors and complications of @entity6 ( @entity6 ) and gestational @entity3 (GH) in a population of primiparas, who had birth care at the Ceilandia Regional Hospital of Brasilia - Federal District. METHODS: Case-control study was conducted from November 2009 to December 2010 in a population of primiparas. We included all primiparas diagnosed with @entity6 /GH, with random choice of normotensive primiparas in a ratio of 1:3. The variables studied as socio-demographic, @entity4 were collected using pre-tested questionnaire, after informed consent of the pregnant @entity0 . Chi-square and Fisher's multiple comparison were used in the data analysis, considering results significant when p <0.05. RESULTS: Among 1264 primiparas analyzed, 972 (76.9%) were normotensive and 292 (23.1%) @entity3 @entity0 , being 64 (22%) with gestational @entity3 and 228 (78%) with @entity6 . Risk factors such as maternal age over 35years, @entity0 whose mother and/or sister with chronic @entity3 history or who developed @entity3 during pregnancy, use of male condom as a contraceptive method, @entity1 and excessive @entity5 during pregnancy showed statistically significant correlation with development of the pathology. CONCLUSION: The development of @entity3 in primiparous @entity0 is associated with family history and @entity1 , factors that can be used as screening for early identification of @entity0 at risk of @entity6 development.

title: PP175. Gestational XXXX syndromes: Risk factors identification and complications in a primiparous population.

answer: @entity3


abstract: PURPOSE: The dysfunctional sympathetic nervous system in individuals with cervical @entity4 (CSCI) impairs adrenergic responses and may, therefore, contribute to the blunted post-exercise cytokine response. The purpose of this study was to investigate an alternative way to exercise to induce an acute cytokine response by passive core temperature elevation in CSCI. METHODS: Seven male @entity0 with a motor complete CSCI and 8 male able-bodied controls were immersed for 60  min in water set at a temperature 2    C above the individuals' resting oesophageal temperature. Blood was collected pre, post, and every hour up to 4  h post-immersion. RESULTS: Hot water immersion resulted in an @entity1 plasma concentration mean increase of 133      144  % in both groups (P  =  0.001). On a group level, @entity1 plasma concentrations were 68      38  % higher in CSCI (P  =  0.06). In both groups, @entity2 increased by 14      11  % (P  =  0.02) and @entity3 by 18      17  % (P  =  0.05). @entity5 plasma concentrations were significantly reduced in CSCI (P  <  0.05) and did not increase following immersion. CONCLUSIONS: Passive elevation of core temperature acutely elevates @entity1 , @entity2 and @entity3 in CSCI despite a blunted adrenergic response, which is in contrast to earlier exercise interventions in CSCI. The present study lays the foundation for future studies to explore water immersion as an alternative to exercise to induce an acute cytokine response in CSCI.

title: Hot water immersion induces an acute cytokine response in cervical XXXX .

answer: @entity4


abstract: OBJECTIVE: To study operative mortality and long-term survival following emergency operations for @entity2 . DESIGN: Retrospective survey in a university hospital. MATERIALS: Two hundred and twenty-seven @entity0 with median age 72 years, (17% @entity0 ). METHODS: Founded on data from the Norwegian Registrar's Office, operative mortality and long-term survival was estimated using the life-table method. Expected survival for demographically matched subgroups was calculated from death rate tables issued by the Norwegian Central Bureau of Statistics. RESULTS: Operative mortality was 41% for the 175 @entity0 with @entity3 and 17% for the 52 with imminent @entity1 . The 6-year survival rate was 61% for all the successfully operated @entity0 , and not different from that of a demographically matched population. For the @entity0 of 72 years or older the 6-year survival rate was 53%. This was equal to that of an age and sex matched population. The younger @entity0 had an observed 6-year survival rate of 64%, which was significantly lower than the expected of 84%. The standard mortality rate for this group was 2.25. No statistically significant difference in long-term survival was detected between the two age groups. CONCLUSIONS: Age at the time of the operation for a symptomatic @entity2 does not seem to influence long-term survival. Consequently, younger @entity0 experience a higher relative mortality compared to the older.

title: The influence of age on operative mortality and long-term relative survival following emergency XXXX .

answer: @entity2


abstract: Of 2171 @entity0 who underwent open heart surgery between 1981 and 1986, 41 (1.8%) developed postoperative @entity5 and were treated by closed irrigation drainage or open chest therapy. Six @entity0 , (mean age 59 years) developed @entity2 of the right ventricular free wall. The primary procedures were: resection of @entity1 (2), mitral valve replacement (1), coronary bypass grafting (1), removal of a left @entity6 (1) and repair of post- @entity4 @entity2 of the left ventricle (1). In 2 @entity0 , @entity2 occurred in the operating theatre during revision of the irrigation drainage. Both @entity0 died after repair. In 4 @entity0 , @entity2 occurred during coughing. One died before surgery. In the 3 other cases, the defects were repaired either by direct suture (2 @entity0 ) or with a pericardial patch (1 @entity0 ) with the aid of normothermic extracorporeal circulation. Three days later, a muscular flap (pectoral or dorso-lumbar) was mobilized to protect the mediastinal viscera. All 3 @entity0 are alive and well. When @entity3 occurs during treatment of @entity5 , an immediate exploration with extracorporeal circulation to close the defect should be considered.

title: Rupture of the right ventricular free wall. An unusual complication of XXXX after cardiac surgery.

answer: @entity5


abstract: Double outlet right ventricle associated with @entity2 , @entity3 and situs solitus of the atria is a subset of double outlet right ventricle related through the surgical treatment. From 1974 to 1985, 14 @entity0 , 5 males, 9 females (mean age 8.9 years, range 13 months-22 years) were operated upon. All @entity0 had @entity5 and normal or large pulmonary arteries. The apex of the heart was to the right in 2 @entity0 , the right and left ventricles were superior and inferior in 2 @entity0 and 1 @entity0 had both anomalies. The @entity4 was subaortic in 11 @entity0 (aorto-mitral discontinuity in 5) and non-committed in 3 @entity0 . Three @entity0 had 2 @entity4 . The aorta was anterior in 3 @entity0 and to the right of the pulmonary artery in 11 @entity0 . All @entity0 , through a transventricular and transatrial approach, had a reconstructive surgery. In 3 @entity0 , an aortic homograft valved conduit was used. One @entity0 had the @entity4 enlarged. There was one early @entity1 (7.1%) from high residual right ventricle pressure and no late @entity1 . One @entity0 had a transient @entity2 . One @entity0 was reoperated upon for a residual @entity4 . All survivors had a good clinical result. Re-evaluation in 8 @entity0 confirmed excellent haemodynamics: the right ventricle to pulmonary artery pressure gradient decreased from 80 mm Hg (range 60-95) preoperatively to 24 mm Hg (range 3-32) postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Exclusive double outlet right ventricle with @entity2 and XXXX . Results of reconstructive surgery.

answer: @entity3


abstract: Double outlet right ventricle associated with @entity2 , @entity3 and situs solitus of the atria is a subset of double outlet right ventricle related through the surgical treatment. From 1974 to 1985, 14 @entity0 , 5 males, 9 females (mean age 8.9 years, range 13 months-22 years) were operated upon. All @entity0 had @entity5 and normal or large pulmonary arteries. The apex of the heart was to the right in 2 @entity0 , the right and left ventricles were superior and inferior in 2 @entity0 and 1 @entity0 had both anomalies. The @entity4 was subaortic in 11 @entity0 (aorto-mitral discontinuity in 5) and non-committed in 3 @entity0 . Three @entity0 had 2 @entity4 . The aorta was anterior in 3 @entity0 and to the right of the pulmonary artery in 11 @entity0 . All @entity0 , through a transventricular and transatrial approach, had a reconstructive surgery. In 3 @entity0 , an aortic homograft valved conduit was used. One @entity0 had the @entity4 enlarged. There was one early @entity1 (7.1%) from high residual right ventricle pressure and no late @entity1 . One @entity0 had a transient @entity2 . One @entity0 was reoperated upon for a residual @entity4 . All survivors had a good clinical result. Re-evaluation in 8 @entity0 confirmed excellent haemodynamics: the right ventricle to pulmonary artery pressure gradient decreased from 80 mm Hg (range 60-95) preoperatively to 24 mm Hg (range 3-32) postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Exclusive double outlet right ventricle with XXXX and @entity3 . Results of reconstructive surgery.

answer: @entity2


abstract: Recent studies suggest that @entity0 with @entity2 exhibit demographic features that differ from those of @entity0 with @entity3 at other intraoral sites. In this study, we sought to explore this hypothesis in greater detail. Records from the University of Connecticut Oral Biopsy Service from 1975 through 1992 inclusive were surveyed for cases of @entity5 . A total of 577 cases were retrieved and analyzed with respect to prevalence, gender distribution, and age at diagnosis. We found that the @entity4 (alveolar ridge included) was the third most common site for oral @entity3 after @entity5 and tongue. Further, the relative proportion of @entity1 at other intraoral subsites remained essentially constant throughout the study period. Male-to-female ratios were significantly greater for @entity1 as compared with both @entity1 and @entity1 of the @entity4 (ridge included). Age was not a significant predictor of @entity1 subsite, and there were no apparent differences between @entity2 of the dentate @entity4 and that of the edentulous ridge. Results of this study indicate that gender-specific predilections exist for @entity3 at different intraoral subsites. These differences suggest the possibility of different etiologic factors and pathogenetic mechanisms involved in @entity2 compared with surface @entity2 at other intraoral sites.

title: XXXX . A case series analysis.

answer: @entity3


abstract: OBJECTIVES: This study aims to evaluate the effect of combining the confidingly preferred modality of radiofrequency (RF) application with intranasal corticosteroid spray treatment on the efficacy of RF and on the number of sessions in @entity0 with @entity2 of inferior turbinate. @entity0 AND METHODS: Fifty @entity0 (37 males, 13 females; mean age 42.9 years; range 15 to 74 years) who admitted with the complaint of nasal obstruction and were detected to have @entity2 inferior turbinate by nasal endoscopy were enrolled in the study. The @entity0 were divided into two groups, each consisting of 25 @entity0 . Before the treatment, the severity of nasal obstruction was evaluated and scored by a visual analogue scale (VAS). Radiofrequency was applied to every @entity0 . Control group received no medical treatment following RF application. Drug group received @entity3 nasal spray (MFNS) at a dose of 200 mcg once daily into both nasal passages for eight weeks following surgery. All @entity0 were asked to return for a control visit at week eight after treatment. Radiofrequency application was repeated in @entity0 who continued to have complaints of nasal blockage. At the end of treatment, @entity0 were reevaluated and VAS scores were recorded. RESULTS: The improvement in VAS scores following treatment was statistically significant in both groups (p<0.05). When the two groups were compared, there was no statistical difference between the two groups before treatment; however there was an improvement in the post-treatment corticostreoid group (p<0.05). The mean session number was calculated to be 1.16 in the control group and 1.08 in the @entity1 treatment group. The difference between the two groups was not statistically significant (p>0.05). CONCLUSION: We recommend the use of intranasal corticosteroids with RF applications to increase the efficacy of radiofrequency.

title: [Evaluation of the effect of intranasal corticosteroid sprays on radiofrequency tissue ablation in the treatment of XXXX inferior turbinate].

answer: @entity2


abstract: BACKGROUND: @entity9 is the first long-acting inhaled @entity7 -agonist available in the US for the maintenance treatment of @entity5 . OBJECTIVE: To compare the safety of @entity9 with that of the short-acting @entity7 -agonist @entity8 . METHODS: Two identically designed, prospective, randomized, double-blind, parallel studies were conducted comparing @entity9 42 micrograms twice daily, @entity8 180 micrograms four times daily, and placebo over 12 weeks in 556 @entity0 (12 to 73 years old) with mild-to-moderate @entity2 . @entity0 in each treatment group could use @entity8 as needed to control acute symptoms. RESULTS: The incidence of potentially drug-related adverse events was similar among the treatment groups (range: 22% to 23%), with @entity1 being the most commonly reported (range: 9% to 10%). No @entity3 occurred during the studies. Concomitant use of > 4 puffs of supplemental @entity8 per day in the @entity9 group produced no increase in the incidence of adverse events either in general or of a cardiovascular nature. There were no statistically significant differences among treatment groups or clinically significant changes from pretreatment values in mean pulse rate, @entity4 , or clinical laboratory values after 12 weeks. There were no clinically significant differences among groups in heart rates nor were there differences in the frequency of supraventricular or @entity6 during 24-hr Holter monitoring. The frequency of @entity5 exacerbations was lowest among @entity0 receiving @entity9 (and highest among those who received placebo), and this rate did not increase over the 12 weeks. @entity5 exacerbations were treated successfully with nebulized @entity8 (2.5 mg), with no evidence of any increased risk of cardiovascular events. CONCLUSIONS: @entity9 42 micrograms twice daily is well-tolerated in @entity0 with @entity5 , having a similar safety profile as that of @entity8 180 micrograms inhaled four times daily or placebo (plus as-needed @entity8 ). Concomitant use of @entity8 , either by @entity10 or nebulization, did not affect the safety of @entity9 . Extensive cardiovascular monitoring revealed no significant cardiovascular adverse effects or arrhythmogenic effects associated with @entity9 over 12 weeks.

title: Safety of XXXX in the maintenance treatment of @entity5 .

answer: @entity9


abstract: BACKGROUND: @entity9 is the first long-acting inhaled @entity7 -agonist available in the US for the maintenance treatment of @entity5 . OBJECTIVE: To compare the safety of @entity9 with that of the short-acting @entity7 -agonist @entity8 . METHODS: Two identically designed, prospective, randomized, double-blind, parallel studies were conducted comparing @entity9 42 micrograms twice daily, @entity8 180 micrograms four times daily, and placebo over 12 weeks in 556 @entity0 (12 to 73 years old) with mild-to-moderate @entity2 . @entity0 in each treatment group could use @entity8 as needed to control acute symptoms. RESULTS: The incidence of potentially drug-related adverse events was similar among the treatment groups (range: 22% to 23%), with @entity1 being the most commonly reported (range: 9% to 10%). No @entity3 occurred during the studies. Concomitant use of > 4 puffs of supplemental @entity8 per day in the @entity9 group produced no increase in the incidence of adverse events either in general or of a cardiovascular nature. There were no statistically significant differences among treatment groups or clinically significant changes from pretreatment values in mean pulse rate, @entity4 , or clinical laboratory values after 12 weeks. There were no clinically significant differences among groups in heart rates nor were there differences in the frequency of supraventricular or @entity6 during 24-hr Holter monitoring. The frequency of @entity5 exacerbations was lowest among @entity0 receiving @entity9 (and highest among those who received placebo), and this rate did not increase over the 12 weeks. @entity5 exacerbations were treated successfully with nebulized @entity8 (2.5 mg), with no evidence of any increased risk of cardiovascular events. CONCLUSIONS: @entity9 42 micrograms twice daily is well-tolerated in @entity0 with @entity5 , having a similar safety profile as that of @entity8 180 micrograms inhaled four times daily or placebo (plus as-needed @entity8 ). Concomitant use of @entity8 , either by @entity10 or nebulization, did not affect the safety of @entity9 . Extensive cardiovascular monitoring revealed no significant cardiovascular adverse effects or arrhythmogenic effects associated with @entity9 over 12 weeks.

title: Safety of @entity9 in the maintenance treatment of XXXX .

answer: @entity5


abstract: The supernatant of @entity2 + cells, isolated from a permanent lymphoblastoid cell clone established from a long term culture of a T cell @entity3 , contained two distinct molecules with suppressive activity on @entity9 -induced PBMC proliferation. This clone does not produce @entity1 , @entity8 , alpha-IFN, gamma-IFN, @entity5 , @entity4 and has not natural killer activity. In the attempt to purify and biochemically characterize the lymphoblastic cell line-derived T-cell SFs, a multi-step chromatographic separation has been used. Two different peaks of biologic activity have been separated by HPLC gel permeation in the range of 100-120 Kd and 75-85 Kd referred to as high molecular weight suppressor factor HMWSF, and low molecular weight suppressor factor LMWSF, respectively. These fractions were then concentrated, dialyzed and further purified by anion exchange HPLC. This chromatographic step allowed us to considerably purify the two SFs. The biologically active fractions derived from the previous chromatographic step were eventually subjected to hydrophobic interaction HPLC (HIC) for final purification. The highly purified material was characterized by @entity6 gel electrophoresis in @entity7 ( @entity0 -PAGE): a single band corresponding to 115 Kd was observed for HMWSF, while LMWSF yielded a single band at 80 Kd. The isoelectric points (pI) of the different SFs was determined by flat-bed isoelectric-focusing: the HMWSF yielded a single band at pI 7.4, while a much lower pI was observed for LMWSF, 3.5-3.6. Studies on temperature lability indicated that both proteins are stable for 3-4 hours at room temperature (RT), 24-36 hours at +4 degrees C and 7-10 days at -80 degrees C.

title: [Immunosuppressive factors produced by a T cell line derived from XXXX ].

answer: @entity3


abstract: 1. The @entity0 consumption (VO2) of unrestrained @entity1 given a 'cafeteria' (high energy, high fat) or control diet was studied. The resting values of @entity5 were the same in each dietary group, whether maintained at 26 degrees C or 6 degrees C. This negative finding suggests that cafeteria feeding is not an important cause of diet-induced thermogenesis (DIT). 2. The response of each group of @entity1 to injected @entity3 or @entity2 was also studied. Each @entity4 could increase VO2 values but the response was much less in cold-adapted @entity1 measured at 6 degrees C. In all experimental circumstances the @entity2 response exceeded that of @entity3 . There was no evidence that the cafeteria diet consistently increased the response to either @entity4 . 3. These results suggest that DIT cannot be equated with non-shivering thermogenesis (NST). Furthermore, it is suggested that @entity2 would be a better agent for measuring the @entity0 equivalent of NST, since it would stimulate the @entity2 receptors as well as the alpha- and beta-adrenoreceptors of brown fat.

title: Thermogenesis and the effect of injected catecholamines on the XXXX consumption of cafeteria-fed @entity1 .

answer: @entity0


abstract: 1. The @entity0 consumption (VO2) of unrestrained @entity1 given a 'cafeteria' (high energy, high fat) or control diet was studied. The resting values of @entity5 were the same in each dietary group, whether maintained at 26 degrees C or 6 degrees C. This negative finding suggests that cafeteria feeding is not an important cause of diet-induced thermogenesis (DIT). 2. The response of each group of @entity1 to injected @entity3 or @entity2 was also studied. Each @entity4 could increase VO2 values but the response was much less in cold-adapted @entity1 measured at 6 degrees C. In all experimental circumstances the @entity2 response exceeded that of @entity3 . There was no evidence that the cafeteria diet consistently increased the response to either @entity4 . 3. These results suggest that DIT cannot be equated with non-shivering thermogenesis (NST). Furthermore, it is suggested that @entity2 would be a better agent for measuring the @entity0 equivalent of NST, since it would stimulate the @entity2 receptors as well as the alpha- and beta-adrenoreceptors of brown fat.

title: Thermogenesis and the effect of injected catecholamines on the @entity0 consumption of cafeteria-fed XXXX .

answer: @entity1


abstract: BACKGROUND: Osteocalcin is a hormone with a complex cross-talk between adipose tissue and the skeleton. The aim of the present study was to explore the relation of osteocalcin with histopathological changes of NALFD @entity0 . SUBJECTS: A population of 69 @entity4 @entity0 was analyzed. A liver biopsy was realized. Weight, fat mass, body mass index, basal @entity3 , @entity6 , @entity6 resistance (HOMA), total @entity2 , LDL @entity2 , HDL- @entity2 , @entity5 and osteocalcin levels were measured. RESULTS: @entity0 were divided in two groups by median osteocalcin value (11.34 ng/mL), group I ( @entity0 with the low values) and group II ( @entity0 with the high values). Only liver @entity1 frequencies were different between groups (group I: 22.9% vs group II: 9.4%; p < 0.05). @entity0 in group I had higher levels of @entity3 (115.6    28.1 mg/dL vs. 103.7    24.3 mg/dL; p < 0.04), HOMA (4.6    3.1 units vs. 3.6    1.8 units; p < 0.04), weight (102.9    32.4 kg vs. 85.9    16.8 kg; p = 0.002) and body mass index (38.3    11.4 kg/m(2) vs. 30.1    5.7 kg/m(2); p = 0.001)) than @entity0 in group II. Osteocalcin was inverse correlated with @entity3 (r =-0.4; p = 0.002) and HOMA (r = -0.3:p = 0.01). CONCLUSION: Osteocalcin is associated with liver @entity1 . However, this association disappeared in a multivariate analysis, and HOMA remained as an independent factor.

title: Relation of osteocalcin with XXXX resistance and histopathological changes of non alcoholic fatty liver disease.

answer: @entity6


abstract: PURPOSE: The diagnostic value of endorectal coil MRI, body coil MRI, transrectal ultrasound, digital rectal examination and @entity2 levels were prospectively analysed in order to define the most accurate preoperative staging method. METHODS: 33 @entity0 with @entity1 , who underwent subsequent prostatectomy, were enrolled in the study and examined on a 1.5T system using the body coil as well as the endorectal surface coil before and after the administration of contrast material. The results were compared to digital rectal examination, @entity2 levels and endorectal ultrasound. RESULTS: Staging accuracy of endorectal coil MRI was 87.9% with a sensitivity of 88.9% and specificity of 86.7%. For body coil MRI, the staging accuracy was 75.7%, the sensitivity 66.7% and the specificity 87.9%, for transrectal ultrasound 69.6%, 41.7% and 100% and for the digital rectal examination 56.6%, 33.3% and 100%, respectively. Prediction was improved by combining results of endorectal coil MRI with @entity2 values. CONCLUSION: Endorectal ultrasound and digital rectal examination both had a tendency to underestimate the extent of the lesion. Endorectal coil MRI proved to be the best preoperative staging method. In combination with @entity2 values, diagnostic accuracy could be further improved. Therefore, local staging of @entity1 could be based on these two parameters alone.

title: Optimization of XXXX staging: comparison of imaging and clinical methods.

answer: @entity1


abstract: A 76-year-old @entity0 was admitted to our hospital because of progressive @entity8 , @entity3 , and consciousness disturbance. @entity10 was diagnosed by chest image findings and laboratory findings of @entity6 and serum. The @entity0 was first given an antimicrobial agent, and chest drainage was performed. Although his general condition improved, his @entity4 @entity1 and chest radiograph findings did not. Then, thoracoscopy under local anesthesia was considered. However, surgery was almost impossible, because he was hemiparetic, with mild conscious disturbance following @entity9 . We decided to insert another drain into the thoracic cavity and continued to perform irrigation with saline in addition to the @entity4 administration of antibiotics for 3 weeks. His general condition gradually improved. Although the volume of drained fluid from the thoracic cavity decreased, the @entity2 did not completely disappear. We then performed irrigation with saline and urokinase for 3 days, from the 40th hospital day. Irrigation drainage using saline was more effective than previously, before urokinase administration; his symptoms and @entity2 markedly improved without antibiotics treatment. He was discharged on the 95th hospital day. For the treatment of chronic emypema, surgery using recently developed thoracoscopic techniques should be considered first, but may not be appropriate for frail elderly with severe @entity4 complications. Conventional intrathoracic irrigation using saline containing urokinase may be a treatment of choice for intractable @entity10 in frail older @entity0 with @entity7 caused by @entity5 .

title: [Successful treatment of thoracic drainage using urokinase for XXXX in an elderly @entity0 ].

answer: @entity10


abstract: A 76-year-old @entity0 was admitted to our hospital because of progressive @entity8 , @entity3 , and consciousness disturbance. @entity10 was diagnosed by chest image findings and laboratory findings of @entity6 and serum. The @entity0 was first given an antimicrobial agent, and chest drainage was performed. Although his general condition improved, his @entity4 @entity1 and chest radiograph findings did not. Then, thoracoscopy under local anesthesia was considered. However, surgery was almost impossible, because he was hemiparetic, with mild conscious disturbance following @entity9 . We decided to insert another drain into the thoracic cavity and continued to perform irrigation with saline in addition to the @entity4 administration of antibiotics for 3 weeks. His general condition gradually improved. Although the volume of drained fluid from the thoracic cavity decreased, the @entity2 did not completely disappear. We then performed irrigation with saline and urokinase for 3 days, from the 40th hospital day. Irrigation drainage using saline was more effective than previously, before urokinase administration; his symptoms and @entity2 markedly improved without antibiotics treatment. He was discharged on the 95th hospital day. For the treatment of chronic emypema, surgery using recently developed thoracoscopic techniques should be considered first, but may not be appropriate for frail elderly with severe @entity4 complications. Conventional intrathoracic irrigation using saline containing urokinase may be a treatment of choice for intractable @entity10 in frail older @entity0 with @entity7 caused by @entity5 .

title: [Successful treatment of thoracic drainage using urokinase for @entity10 in an elderly XXXX ].

answer: @entity0


abstract: @entity6 ( @entity6 ) is characterized by brain @entity1 that occur in about 30 to 50% of @entity0 . To control @entity2 growth potential with maintaining neurocognitive function is important in the recent radiotherapy against brain @entity1 . From this viewpoint, we investigated the utility of repeat stereotactic radiosurgery (SRS) with a linear accelerator in the management of brain @entity1 from @entity6 . Between October 1998 and May 2010, 28 @entity0 harboring brain @entity1 received repeat SRS (20 @entity0 and 8 @entity0 , with the age ranged from 51 to 79). The total number of SRS sessions ranged from 2 to 5, and the total number of lesions in one @entity0 ranged from 1 to 8. @entity3 due to uncontrolled @entity4 was identified in 9 of 28 @entity0 after the repeat SRS, while the remaining 19 @entity0 showed no neurological decline. Out of the 28 @entity0 , 18 @entity0 died by July 1, 2010; 12 @entity0 died of active @entity5 and 6 @entity0 died from progressive @entity4 , considered @entity3 . The 2-year and 4-year overall survival rates were 51% and 23%, respectively, and the median survival time was 26 months. In conclusion, repeat SRS is a preferred option to manage brain @entity1 from @entity6 , leading to a long survival with a decreased neurological decline. Repeat SRS is promising to preserve neurocognition, because the convergent dose distribution decreases the unfavorable influences from radiation on germinal niches, thereby preserving neural stem cells that are responsible for the nervous system repair.

title: Repeat stereotactic radiosurgery in the management of brain @entity1 from XXXX .

answer: @entity6


abstract: @entity6 ( @entity6 ) is characterized by brain @entity1 that occur in about 30 to 50% of @entity0 . To control @entity2 growth potential with maintaining neurocognitive function is important in the recent radiotherapy against brain @entity1 . From this viewpoint, we investigated the utility of repeat stereotactic radiosurgery (SRS) with a linear accelerator in the management of brain @entity1 from @entity6 . Between October 1998 and May 2010, 28 @entity0 harboring brain @entity1 received repeat SRS (20 @entity0 and 8 @entity0 , with the age ranged from 51 to 79). The total number of SRS sessions ranged from 2 to 5, and the total number of lesions in one @entity0 ranged from 1 to 8. @entity3 due to uncontrolled @entity4 was identified in 9 of 28 @entity0 after the repeat SRS, while the remaining 19 @entity0 showed no neurological decline. Out of the 28 @entity0 , 18 @entity0 died by July 1, 2010; 12 @entity0 died of active @entity5 and 6 @entity0 died from progressive @entity4 , considered @entity3 . The 2-year and 4-year overall survival rates were 51% and 23%, respectively, and the median survival time was 26 months. In conclusion, repeat SRS is a preferred option to manage brain @entity1 from @entity6 , leading to a long survival with a decreased neurological decline. Repeat SRS is promising to preserve neurocognition, because the convergent dose distribution decreases the unfavorable influences from radiation on germinal niches, thereby preserving neural stem cells that are responsible for the nervous system repair.

title: Repeat stereotactic radiosurgery in the management of brain XXXX from @entity6 .

answer: @entity1


abstract: Prevalence of @entity1 is high among poor, young, Hispanic inner city @entity0 . Depot- @entity2 ( @entity3 ) is a popular contraceptive choice in this group. @entity3 labelling suggests that @entity1 may worsen with use. In order to identify any association of @entity3 use with worsening @entity1 , we surveyed an English-speaking subset of @entity3 users in a Title-X funded family planning clinic. Eighty @entity0 completed the CES-D scale on two occasions: once about four weeks after a @entity3 injection when the subject would have been exposed to the highest blood levels, and once immediately prior to an injection when recent blood levels of the drug would be somewhat lower (or absent preceding the first injection). The median CES-D score was 14. The scores were not related to timing of the test (pre- or post-injection). The @entity1 scores were somewhat higher among those @entity0 receiving their first @entity3 injection during the study period (i.e., unexposed @entity0 ) and among those @entity0 who had received four or more injections. Scores were unrelated to age or parity, but were somewhat higher in @entity0 who reported fewer years of education or a recent adverse pregnancy outcome. These data provide little evidence of increasing @entity1 with long-term use of @entity3 and no evidence of a short-term effect of dose (within the contraceptive range) on mood. @entity0 at risk of @entity1 should not be denied @entity3 as a contraceptive choice.

title: XXXX in users of @entity2 .

answer: @entity1


abstract: Prevalence of @entity1 is high among poor, young, Hispanic inner city @entity0 . Depot- @entity2 ( @entity3 ) is a popular contraceptive choice in this group. @entity3 labelling suggests that @entity1 may worsen with use. In order to identify any association of @entity3 use with worsening @entity1 , we surveyed an English-speaking subset of @entity3 users in a Title-X funded family planning clinic. Eighty @entity0 completed the CES-D scale on two occasions: once about four weeks after a @entity3 injection when the subject would have been exposed to the highest blood levels, and once immediately prior to an injection when recent blood levels of the drug would be somewhat lower (or absent preceding the first injection). The median CES-D score was 14. The scores were not related to timing of the test (pre- or post-injection). The @entity1 scores were somewhat higher among those @entity0 receiving their first @entity3 injection during the study period (i.e., unexposed @entity0 ) and among those @entity0 who had received four or more injections. Scores were unrelated to age or parity, but were somewhat higher in @entity0 who reported fewer years of education or a recent adverse pregnancy outcome. These data provide little evidence of increasing @entity1 with long-term use of @entity3 and no evidence of a short-term effect of dose (within the contraceptive range) on mood. @entity0 at risk of @entity1 should not be denied @entity3 as a contraceptive choice.

title: @entity1 in users of XXXX .

answer: @entity2


abstract: BACKGROUND: @entity1 is a major public health problem in India. A key factor that has led to lack of improvement in prognosis of @entity1 over the years, is delay in diagnosis and treatment. In many instances, a significant proportion of oral @entity5 develop from @entity2 and conditions. Identification of such lesions and conditions is very important in order to prevent @entity1 . The role of @entity4 has been studied and holds promise as an indicator to predict @entity1 . So we designed a study to analyze the prevalence of fungal hyphae in biopsies of @entity0 with clinically diagnosed cases of @entity2 and conditions. AIMS AND OBJECTIVES: To determine and compare the prevalence of fungal hyphae in biopsies of @entity0 with clinically diagnosed cases of potentially malignant lesions and conditions and to assess the possible association between the degree of @entity10 and presence or absence of fungal hyphae. MATERIALS AND METHODS: Clinically suspected and histopathologically diagnosed 70 cases of potentially malignant lesions and conditions (29 @entity12 , 16 @entity3 and 25 lichen planus) made up the study group. Three tissue sections (5 m) of each were stained with @entity8 and @entity9 (H and E), periodic acid- @entity11 (PAS) and Grocott's @entity7 silver (GMS) and evaluated for fungal hyphae. The data collected was statistically analyzed by using Chi-square test and Statistical Package for Social Sciences (SPSS) software. RESULTS: The estimated prevalence of fungal hyphae in cases with or without @entity6 in @entity12 was 41.4%, lichen planus 36% and @entity3 25%. There was a significant association between degree of @entity10 with presence or absence of fungal hyphae in all the study groups. CONCLUSION: Presence of fungal hyphae in potentially malignant lesions and conditions may prove to be a useful indicator in predicting @entity1 .

title: Prevalence of fungal hyphae in potentially malignant lesions and conditions-does its occurrence play a role in XXXX ?

answer: @entity10


abstract: CONTEXT: @entity3 is predominantly due to exaggerated host response to pathogenic microorganisms and their products which causes an imbalance between the reactive @entity1 species-antioxidant in gingival crevicular fluid (GCF). @entity2 is an important redox regulator in GCF and maintenance of stable @entity2 ( @entity4 ): @entity6 ( @entity6 ) ratio is essential for periodontal health. AIMS: The present study was undertaken to evaluate and compare the level of @entity2 and redox balance ( @entity4 : @entity6 ratio) in GCF of @entity5 @entity0 , periodontally healthy controls and also to evaluate the effect of nonsurgical periodontal therapy on the level of @entity2 and redox balance during 3 months postoperative visit. STUDY DESIGN: Baseline GCF samples were collected from 20 @entity5 @entity0 and 20 periodontally healthy subjects for @entity4 and @entity6 levels estimation. @entity3 @entity0 were recalled 3 months postnonsurgical periodontal therapy to re-sample GCF. MATERIALS AND METHODS: @entity4 and @entity6 levels were measured by high-performance liquid chromatography. The values were statistically analyzed by Paired t-test. RESULTS: The mean @entity4 and @entity6 values in GCF were found to be significantly lower in @entity3 @entity0 pre- and 3 months post-nonsurgical periodontal therapy, compared with those in the control group subjects. In addition, the successful nonsurgical therapy even though leading to a significant improvement in the @entity4 and @entity6 levels, does not restore @entity2 concentration to the levels seen in healthy subjects. CONCLUSION: Successful nonsurgical periodontal therapy leads to significant improvement in the redox balance ( @entity4 : @entity6 ratio) in @entity5 @entity0 .

title: Evaluation of @entity2 level in gingival crevicular fluid in periodontal health, in XXXX and after nonsurgical periodontal therapy: A clinicobiochemical study.

answer: @entity5


abstract: CONTEXT: @entity3 is predominantly due to exaggerated host response to pathogenic microorganisms and their products which causes an imbalance between the reactive @entity1 species-antioxidant in gingival crevicular fluid (GCF). @entity2 is an important redox regulator in GCF and maintenance of stable @entity2 ( @entity4 ): @entity6 ( @entity6 ) ratio is essential for periodontal health. AIMS: The present study was undertaken to evaluate and compare the level of @entity2 and redox balance ( @entity4 : @entity6 ratio) in GCF of @entity5 @entity0 , periodontally healthy controls and also to evaluate the effect of nonsurgical periodontal therapy on the level of @entity2 and redox balance during 3 months postoperative visit. STUDY DESIGN: Baseline GCF samples were collected from 20 @entity5 @entity0 and 20 periodontally healthy subjects for @entity4 and @entity6 levels estimation. @entity3 @entity0 were recalled 3 months postnonsurgical periodontal therapy to re-sample GCF. MATERIALS AND METHODS: @entity4 and @entity6 levels were measured by high-performance liquid chromatography. The values were statistically analyzed by Paired t-test. RESULTS: The mean @entity4 and @entity6 values in GCF were found to be significantly lower in @entity3 @entity0 pre- and 3 months post-nonsurgical periodontal therapy, compared with those in the control group subjects. In addition, the successful nonsurgical therapy even though leading to a significant improvement in the @entity4 and @entity6 levels, does not restore @entity2 concentration to the levels seen in healthy subjects. CONCLUSION: Successful nonsurgical periodontal therapy leads to significant improvement in the redox balance ( @entity4 : @entity6 ratio) in @entity5 @entity0 .

title: Evaluation of XXXX level in gingival crevicular fluid in periodontal health, in @entity5 and after nonsurgical periodontal therapy: A clinicobiochemical study.

answer: @entity2


abstract: OBJECTIVES: We evaluated the biological interaction between blood pressure (BP) and uterine artery Doppler (UAD) in the second trimester for early-onset @entity1 (EO-PE) risk. STUDY DESIGN: A prospective cohort study. MAIN OUTCOME MEASURES: In 2410 pregnant @entity0 , mean pulsatility index (mPI) and mean notch depth index (mNDI) were examined by UAD at 16-23weeks' gestation. We defined EO-PE as PE with onset at <34weeks, abnormal UAD as coexistence of mPI   90th percentile and mNDI   90th percentile, and high BP as systolic BP/diastolic BP   120/80mmHg. Abnormal UAD and high BP were combined as a series of dummy variables, and were entered into a logistic regression model. The relative excess risk due to biological interaction (RERI) was calculated using the following equation: RERI=odds ratio (OR) in @entity0 with both high BP and abnormal UAD - OR in @entity0 with high BP alone - OR in @entity0 with abnormal UAD alone +1. RERI   10 was considered as strong. RESULTS: EO-PE and @entity2 ( @entity2 ) occurred in 1.1% and 1.2%, respectively. Adjusted odds ratio (95% CI) in @entity0 with abnormal UAD alone, high BP alone, and both high BP and abnormal UAD for predicting EO-PE was 4.3 (0.37-49), 12 (2.6-55) and 85 (17-422), respectively; and that for predicting @entity2 was 6.3 (1.5-27), 6.1 (2.1-17) and 15 (3.6-61), respectively. The RERI for EO-PE and @entity2 was 70 and 3.3, respectively. CONCLUSION: High BP and abnormal UAD may have a strong biological interaction for the occurrence of EO-PE.

title: Biophysical interaction between blood pressure and uterine artery Doppler for the occurrence of early-onset XXXX : A prospective cohort study.

answer: @entity1


abstract: Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of @entity1 in nasal cavity air ( @entity4 ) is influenced by @entity3 and/or @entity2 , both of which are common causes of UACS. We measured @entity4 levels in @entity0 with UACS and those with other causes. We also examined the usefulness of measuring @entity4 for differentiating @entity0 with @entity2 from those without @entity2 . The study included 93 adult @entity0 with prolonged cough lasting more than threeweeks. Etiologies of cough were identified and @entity4 was measured at the initial investigation. UACS was diagnosed in 58 @entity0 (62.4%), and @entity2 was identified in 11 (19.0%) of the 58 @entity0 with UACS. Levels of @entity4 in UACS did not differ from non-UACS etiologies (316.2  129.2 vs. 334.9  88.2 ppb; p=0.452), suggesting that the measurement of @entity4 could not discriminate UACS from other etiologies of prolonged cough. However, @entity0 with @entity2 showed significantly decreased @entity4 levels (190.1  114.8ppb) compared with @entity0 with UACS without @entity2 (345.7  114.6ppb; p<0.001) and non-UACS @entity0 (334.9  88.2 ppb; p<0.001). In a receiver operating characteristic curve analysis for the diagnosis of @entity2 in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a @entity4 cutoff value of 279.0 ppb. These findings imply that the measurement of @entity4 could be useful for diagnosis of prolonged cough associated with @entity2 .

title: Measurement of nasal @entity1 is useful for the diagnosis of XXXX -induced prolonged cough.

answer: @entity2


abstract: Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of @entity1 in nasal cavity air ( @entity4 ) is influenced by @entity3 and/or @entity2 , both of which are common causes of UACS. We measured @entity4 levels in @entity0 with UACS and those with other causes. We also examined the usefulness of measuring @entity4 for differentiating @entity0 with @entity2 from those without @entity2 . The study included 93 adult @entity0 with prolonged cough lasting more than threeweeks. Etiologies of cough were identified and @entity4 was measured at the initial investigation. UACS was diagnosed in 58 @entity0 (62.4%), and @entity2 was identified in 11 (19.0%) of the 58 @entity0 with UACS. Levels of @entity4 in UACS did not differ from non-UACS etiologies (316.2  129.2 vs. 334.9  88.2 ppb; p=0.452), suggesting that the measurement of @entity4 could not discriminate UACS from other etiologies of prolonged cough. However, @entity0 with @entity2 showed significantly decreased @entity4 levels (190.1  114.8ppb) compared with @entity0 with UACS without @entity2 (345.7  114.6ppb; p<0.001) and non-UACS @entity0 (334.9  88.2 ppb; p<0.001). In a receiver operating characteristic curve analysis for the diagnosis of @entity2 in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a @entity4 cutoff value of 279.0 ppb. These findings imply that the measurement of @entity4 could be useful for diagnosis of prolonged cough associated with @entity2 .

title: Measurement of nasal XXXX is useful for the diagnosis of @entity2 -induced prolonged cough.

answer: @entity1


abstract: A 30-year-old @entity0 , who was diagnosed with Beh  et disease at 10 years of age, was hospitalized because of transient @entity5 after presenting with high @entity1 . Brain MRI revealed @entity6 in the area supplied by the anterior cerebral arteries. Analysis of cerebrospinal fluid (CSF) showed pleocytosis and a high @entity3 ( @entity3 ) concentration (668   pg/ml). The @entity0 was diagnosed with acute @entity2 associated with exacerbation of Beh  et disease. After initiation of corticosteroid therapy, his clinical symptoms improved, and the CSF @entity3 concentration decreased. One year later, the @entity0 developed high @entity1 . Brain MRI showed an @entity6 in the right putamen, and CSF analysis showed an elevated @entity3 concentration (287   pg/ml). Brain CT angiography revealed @entity4 of the @entity7 and occlusion of the right anterior cerebral artery, which had been well visualized one year previously. Involvement of the intracranial cerebral arteries in Beh  et disease is extremely rare. To the best of our knowledge, this is the first case report of a @entity0 with recurrent symptomatic @entity2 associated with high @entity1 , which suggests exacerbation of Beh  et disease.

title: A case of Beh  et disease developing recurrent XXXX .

answer: @entity2


abstract: PURPOSE: Recent publications have reported contradictory results of pretreatment diffusion-weighted magnetic resonance imaging (DWI) for the prediction of chemoradiotherapeutic response in primary @entity3 of the head and neck ( @entity2 ). Therefore, we evaluated the diagnostic performance of DWI obtained with both standard (b = 0 and 1,000 s/mm(2)) and high (b = 0 and 2,000 s/mm(2)) b-values for predicting response to induction chemotherapy in HNSCCs. METHODS: For 25 @entity0 with primary @entity2 who underwent DWI with both standard and high b-values prior to treatment, we calculated corresponding apparent diffusion coefficient (ADC) maps. Regions of interest containing the @entity1 were drawn on every section of ADC maps and summated to make volume-based data of the entire @entity1 . Histogram parameters (mean ADC, kurtosis, and skewness) were correlated with treatment response using unpaired Student t test. Univariate and multivariate analysis of the ADC parameters, @entity0 age, sex, whole @entity1 volume, and T stage were also performed to predict @entity1 response to induction chemotherapy. RESULTS: Response to induction chemotherapy was good in 13 of the 25 @entity0 and poor in 12. The mean ADC values of good responders at standard b-value (ADC1000), 1.23    0.34 (* 10(-3) mm(2)/s), and high b-value (ADC2000), 0.62    0.14 (* 10(-3) mm(2)/s), were lower than those of poor responders (ADC1000, 1.32    0.28 [* 10(-3) mm(2)/s]; ADC2000, 0.76    0.15 [* 10(-3) mm(2)/s]), but significant difference was achieved only at the ADC2000 map (P = 0.02). In addition, mean @entity1 volume prior to treatment of good responders was smaller than that of poor responders. However, at multiple logistic regression analysis, only the mean ADC2000 value remained as a significant predictor of response to induction chemotherapy. CONCLUSION: DWI with high b-values (b = 0 and 2,000 s/mm(2)) as an assessment of ADC values may help predict @entity1 response to neoadjuvant chemotherapy for primary HNSCCs.

title: XXXX of the Head and Neck: Comparison of Diffusion-weighted MRI at b-values of 1,000 and 2,000 s/mm(2) to Predict Response to Induction Chemotherapy.

answer: @entity3


abstract: AIM: This study aimed to explore the test-retest reliability of the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test for @entity1 ( @entity2 [ @entity3 ]), the concurrent validity of this test with the Vineland Adaptive Behavior Scales (VABS-II), and parents' perceptions of usability. METHOD: A convenience sample of @entity0 (n=39) was recruited nationally through disability organizations. Parents of young @entity0 aged 10 to 18  years (mean age 14y 10mo, SD 2y 8mo; 34 males, five females) who reported a diagnosis of @entity3 were eligible to participate. Parents completed the VABS-II questionnaire once and the @entity2 ( @entity3 ) twice (n=29) no more than 3  weeks apart (mean 12d) using computer-simulated administration. Parents also answered questions about the usability of these instruments. We examined score reliability using intraclass correlation coefficients (ICCs) and we explored the relationship between instruments using Spearman's rank correlation coefficients. Parent responses were grouped by common content; content categories were triangulated by an additional reviewer. RESULTS: Intraclass correlation coefficients indicate excellent reliability for all @entity2 ( @entity3 ) domain scores (ICC>= 0.86). @entity2 ( @entity3 ) and VABS-II domain scores correlated as expected or stronger than expected (0.57-0.81). Parents reported that the computer-based @entity2 ( @entity3 ) was easy to use and included fewer irrelevant questions than the VABS-II instrument. INTERPRETATION: These findings suggest that the @entity2 ( @entity3 ) is a reliable assessment that parents can easily use. The @entity2 ( @entity3 ) operationalizes the International Classification of Function, Disability and Health for @entity0 and Youth constructs of 'activity' and 'participation', and this preliminary research suggests that the instrument's constructs are related to those of VABS-II.

title: Validity, reliability, and usability of the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test for XXXX .

answer: @entity1


abstract: BACKGROUND: A subgroup of young @entity0 with @entity1 ( @entity1 ) have significant @entity2 (phonology, grammar, vocabulary), although such impairments are not considered to be core symptoms of and are not unique to @entity1 . @entity0 with @entity4 ( @entity4 ) display similar @entity2 . Given evidence for phenotypic and possibly etiologic overlap between @entity4 and @entity1 , it has been suggested that @entity2 @entity0 with @entity1 ( @entity1   +   @entity2 , ALI) may be characterized as having both @entity1 and @entity4 . However, the extent to which the language phenotypes in @entity4 and ALI can be viewed as similar or different depends in part upon the age of the individuals studied. The purpose of the current study is to examine differences in memory abilities, specifically those that are key "markers" of heritable @entity4 , among young school-age @entity0 with @entity4 , ALI, and @entity3 ( @entity1   +   language normal). METHODS: In this cross-sectional study, three groups of @entity0 between ages 5 and 8 years participated: @entity4 (n   =   18), ALI (n   =   22), and @entity3 (n   =   20). A battery of cognitive, language, and @entity1 assessments was administered as well as a nonword repetition (NWR) test and measures of verbal memory, visual memory, and processing speed. RESULTS: NWR difficulties were more severe in @entity4 than in ALI, with the largest effect sizes in response to nonwords with the shortest syllable lengths. Among @entity0 with @entity1 , NWR difficulties were not associated with the presence of impairments in multiple @entity1 domains, as reported previously. Verbal memory difficulties were present in both @entity4 and ALI groups relative to @entity0 with @entity3 . Performance on measures related to verbal but not visual memory or processing speed were significantly associated with the relative degree of @entity2 in @entity0 with @entity1 , supporting the role of verbal memory difficulties in @entity2 among early school-age @entity0 with @entity1 . CONCLUSIONS: The primary difference between @entity0 with @entity4 and ALI was in NWR performance, particularly in repeating two- and three-syllable nonwords, suggesting that shared difficulties in early language learning found in previous studies do not necessarily reflect the same underlying mechanisms.

title: Memory in language-impaired @entity0 with and without XXXX .

answer: @entity3


abstract: BACKGROUND: A subgroup of young @entity0 with @entity1 ( @entity1 ) have significant @entity2 (phonology, grammar, vocabulary), although such impairments are not considered to be core symptoms of and are not unique to @entity1 . @entity0 with @entity4 ( @entity4 ) display similar @entity2 . Given evidence for phenotypic and possibly etiologic overlap between @entity4 and @entity1 , it has been suggested that @entity2 @entity0 with @entity1 ( @entity1   +   @entity2 , ALI) may be characterized as having both @entity1 and @entity4 . However, the extent to which the language phenotypes in @entity4 and ALI can be viewed as similar or different depends in part upon the age of the individuals studied. The purpose of the current study is to examine differences in memory abilities, specifically those that are key "markers" of heritable @entity4 , among young school-age @entity0 with @entity4 , ALI, and @entity3 ( @entity1   +   language normal). METHODS: In this cross-sectional study, three groups of @entity0 between ages 5 and 8 years participated: @entity4 (n   =   18), ALI (n   =   22), and @entity3 (n   =   20). A battery of cognitive, language, and @entity1 assessments was administered as well as a nonword repetition (NWR) test and measures of verbal memory, visual memory, and processing speed. RESULTS: NWR difficulties were more severe in @entity4 than in ALI, with the largest effect sizes in response to nonwords with the shortest syllable lengths. Among @entity0 with @entity1 , NWR difficulties were not associated with the presence of impairments in multiple @entity1 domains, as reported previously. Verbal memory difficulties were present in both @entity4 and ALI groups relative to @entity0 with @entity3 . Performance on measures related to verbal but not visual memory or processing speed were significantly associated with the relative degree of @entity2 in @entity0 with @entity1 , supporting the role of verbal memory difficulties in @entity2 among early school-age @entity0 with @entity1 . CONCLUSIONS: The primary difference between @entity0 with @entity4 and ALI was in NWR performance, particularly in repeating two- and three-syllable nonwords, suggesting that shared difficulties in early language learning found in previous studies do not necessarily reflect the same underlying mechanisms.

title: Memory in language-impaired XXXX with and without @entity3 .

answer: @entity0


abstract: The failure of medical therapy for @entity2 may be followed by its perforation, a complication associated with high mortality. We assessed the role of percutaneous catheter drainage in management of the sequelae of @entity1 in 13 critically ill @entity0 ; 22 intrahepatic lesions, three of which were multiloculated, were drained. Catheters were also placed in 17 extrahepatic collections: pleural space (n = 5), subphrenic (n = 7), perihepatic/subhepatic (n = 3), greater sac of peritoneum (n = 2). No attempt at percutaneous drainage failed. Prompt resolution of clinical features following drainage was a uniform feature. Successful resolution of the abscesses occurred within 20 days in 11 @entity0 . In the remaining two, catheters needed to be retained in situ for 35 and 50 days. The mean hospital stay was 15 days (range 10-20 days). 100% @entity0 survival was achieved, without a single morbid episode. Our results suggest that @entity0 with @entity1 can be effectively and safely managed by percutaneous catheter drainage irrespective of the extent of extrahepatic contamination.

title: XXXX : the role of percutaneous catheter drainage.

answer: @entity2


abstract: The @entity0 lower esophageal sphincter (LES) is believed to be innervated by nonadrenergic, noncholinergic inhibitory nerves, and cholinergic excitatory nerves. In idiopathic @entity1 , LES relaxation is abnormal because the inhibitory nerves to the sphincter are either absent or functionally impaired. The integrity of cholinergic excitatory nerves to the LES, however, has not been thoroughly evaluated. In 27 @entity0 with untreated idiopathic @entity1 , and 21 healthy volunteers, we investigated the hypothesis that postganglionic cholinergic nerves to the LES are functionally intact in @entity1 . The LES responses to @entity4 , @entity5 , @entity2 , @entity3 , and @entity6 were assessed. In 2 @entity1 @entity0 , patterns of fasting motor activity in the LES were investigated during overnight manometric studies. Resting LES pressure was significantly greater in the @entity1 @entity0 , 41 +/- 4 mmHg (mean +/- SE), than in the normal subjects, 20 +/- 2 mmHg. @entity4 significantly reduced LES pressure in both groups by 30%-75%. @entity5 increased LES pressure in the @entity1 @entity0 but had negligible effect on the normal subjects. The LES in @entity1 @entity0 exhibited an increased sensitivity to both @entity2 and @entity6 compared with the normal subjects. In both @entity0 who underwent an overnight manometric study, the LES exhibited cyclic phasic contractile activity synchronous with gastric contractions during the migrating motor complex. We conclude that the study findings support the hypothesis that postganglionic cholinergic LES innervation in @entity1 @entity0 is either normal or only minimally impaired, in contrast to the marked impairment of the inhibitory nerves governing LES relaxation.

title: Integrity of cholinergic innervation to the lower esophageal sphincter in XXXX .

answer: @entity1


abstract: Polyfunctional @entity9 ( @entity7 ) is increasingly used as a water-based @entity3 , paint primers, lacquers, topcoats and other protective coatings. The crosslinker is made by reacting multifunctional acrylic monomer with a highly reactive @entity9 compound. @entity2 or @entity1 from @entity7 has not been reported previously. During 1978-1991 we came across nine cases with @entity1 from @entity7 : two had @entity4 ( @entity4 ), four had @entity6 and three had both of them. Five of the @entity0 were parquet layers, two were fibreboard painters, one was a spray painter and one was a salesman of @entity7 products. @entity4 was diagnosed by positive allergic patch test reactions with @entity7 in a dilution series in petrolatum: 0.32%-0.5% gave a 2(+)-3+ @entity1 in the five cases with @entity4 but 0.1% gave only a weak reaction in one case, whereas the @entity8 patch test series was negative. The diagnosis of seven cases of @entity6 due to @entity7 hardener was based on symptoms related to exposure to @entity7 hardener at work, and on positive provocation tests with @entity7 hardener. One had an immediate type reaction, one a had a dual reaction, and the others had late reactions. The positive reactions with the @entity7 hardener and the negative reactions with the @entity5 compounds indicate that @entity7 caused @entity4 which is different from the previous reports in which acrylates present as impurities in the @entity7 hardener caused the sensitization.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Occupational @entity2 caused by polyfunctional XXXX hardener.

answer: @entity9


abstract: Polyfunctional @entity9 ( @entity7 ) is increasingly used as a water-based @entity3 , paint primers, lacquers, topcoats and other protective coatings. The crosslinker is made by reacting multifunctional acrylic monomer with a highly reactive @entity9 compound. @entity2 or @entity1 from @entity7 has not been reported previously. During 1978-1991 we came across nine cases with @entity1 from @entity7 : two had @entity4 ( @entity4 ), four had @entity6 and three had both of them. Five of the @entity0 were parquet layers, two were fibreboard painters, one was a spray painter and one was a salesman of @entity7 products. @entity4 was diagnosed by positive allergic patch test reactions with @entity7 in a dilution series in petrolatum: 0.32%-0.5% gave a 2(+)-3+ @entity1 in the five cases with @entity4 but 0.1% gave only a weak reaction in one case, whereas the @entity8 patch test series was negative. The diagnosis of seven cases of @entity6 due to @entity7 hardener was based on symptoms related to exposure to @entity7 hardener at work, and on positive provocation tests with @entity7 hardener. One had an immediate type reaction, one a had a dual reaction, and the others had late reactions. The positive reactions with the @entity7 hardener and the negative reactions with the @entity5 compounds indicate that @entity7 caused @entity4 which is different from the previous reports in which acrylates present as impurities in the @entity7 hardener caused the sensitization.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Occupational XXXX caused by polyfunctional @entity9 hardener.

answer: @entity2


abstract: BACKGROUND: Childhood adversities have been associated with adult @entity4 in the general population. However, most research has focused on only a few types of maltreatment and has not always controlled for factors correlated with early adversities and @entity4 . OBJECTIVES: The aim of this study was to investigate the relationship between early adversities and @entity4 , while controlling for a range of potential explanatory factors. METHODS: We analyzed data from the 2012 Canadian Community Health Survey - Mental Health. Using a representative sample of 10,358 @entity0 and 12,638 @entity0 , we undertook gender-specific logistic regression analyses to determine the association between number and type of self-reported childhood adversities (physical abuse, @entity3 , and witnessing parental domestic violence) and @entity4 , while controlling for sociodemographics, comorbid adversities, health behaviors, @entity2 , and @entity1 . RESULTS: In total, 6.5% of @entity0 and 14.2% of @entity0 reported @entity4 . All three adversities were significantly associated with @entity4 for both genders, even after controlling for a range of variables. The fully adjusted odds of @entity4 associated with physical abuse, parental domestic violence, and @entity3 were 1.61 (95% confidence interval [CI]   =   1.42-1.83), 1.64 (95% CI   =   1.39-1.93), and 1.32 (95% CI   =   1.11-1.57), respectively, for @entity0 , and 1.50 (95% CI   =   1.25-1.80), 1.52 (95% CI   =   1.16-1.98), and 1.70 (95% CI   =   1.22-2.36) for @entity0 . Greater number of adversities was also associated with increasing odds of @entity4 . @entity0 reporting all three adversities had over three times (odds ratio   =   3.26; 95% CI   =   2.09-5.07) and @entity0 over two times (OR   =   2.85; 95% CI   =   2.25-3.60) the odds of @entity4 compared with those without childhood adversities. CONCLUSIONS: Number and type of early adversities are associated with @entity4 among Canadian @entity0 and @entity0 .

title: The Painful Legacy of Childhood Violence: XXXX Among Adult Survivors of Adverse Childhood Experiences.

answer: @entity4


abstract: BACKGROUND: Biological studies on megakaryopoiesis have been hampered by the scarcity of megakaryocytes in normal bone marrow and difficulty in long term culture. Alternatively, @entity5 cell lines with megakaryocytic differentiation potential may provide good models to counter these problems. METHODS: Leukemic cells from a @entity0 with @entity7 were put into long-term culture and established into a cell line which was designated as VGH-MK1. The VGH-MK1 cells were challenged with differentiation agents and/or cytokines, and the differentiation of these cells was examined using morphological, immunocytochemical and surface-marker studies. RESULTS: Morphologically, VGH-MK1 cells had prominent nucleoli and basophilic cytoplasm with some protrusions, but large cells were occasionally seen. Under regular culture condition, the cells had a doubling time of 36-48 hours. The cloned cell line exhibited markers characteristic of megakaryoblasts after differentiation induction. Specifically, when stimulated with @entity1 ( @entity2 ), cells became larger and had large or multinuclei. They were induced to express platelet glycoproteins GPIb ( @entity8 ), @entity3 /IIIa ( @entity3 ), and @entity4 ( @entity4 ) antigens, but not erythroid nor lymphoid markers. Platelet peroxidase (PPO) activity was also induced. @entity6 did not exhibit similar differentiation-inducing effects. In contrast, it counteracted the effects induced by @entity2 . CONCLUSIONS: An unique @entity0 @entity5 cell line, VGH-MK1, has been established here. It could be induced to exhibit some characteristics of megakaryocytic lineage, and may be an useful model for the biological studies of megakaryopoiesis.

title: Induction of megakaryocytic differentiation in a newly established @entity0 @entity5 cell line by XXXX .

answer: @entity1


abstract: BACKGROUND: Biological studies on megakaryopoiesis have been hampered by the scarcity of megakaryocytes in normal bone marrow and difficulty in long term culture. Alternatively, @entity5 cell lines with megakaryocytic differentiation potential may provide good models to counter these problems. METHODS: Leukemic cells from a @entity0 with @entity7 were put into long-term culture and established into a cell line which was designated as VGH-MK1. The VGH-MK1 cells were challenged with differentiation agents and/or cytokines, and the differentiation of these cells was examined using morphological, immunocytochemical and surface-marker studies. RESULTS: Morphologically, VGH-MK1 cells had prominent nucleoli and basophilic cytoplasm with some protrusions, but large cells were occasionally seen. Under regular culture condition, the cells had a doubling time of 36-48 hours. The cloned cell line exhibited markers characteristic of megakaryoblasts after differentiation induction. Specifically, when stimulated with @entity1 ( @entity2 ), cells became larger and had large or multinuclei. They were induced to express platelet glycoproteins GPIb ( @entity8 ), @entity3 /IIIa ( @entity3 ), and @entity4 ( @entity4 ) antigens, but not erythroid nor lymphoid markers. Platelet peroxidase (PPO) activity was also induced. @entity6 did not exhibit similar differentiation-inducing effects. In contrast, it counteracted the effects induced by @entity2 . CONCLUSIONS: An unique @entity0 @entity5 cell line, VGH-MK1, has been established here. It could be induced to exhibit some characteristics of megakaryocytic lineage, and may be an useful model for the biological studies of megakaryopoiesis.

title: Induction of megakaryocytic differentiation in a newly established @entity0 XXXX cell line by @entity1 .

answer: @entity5


abstract: BACKGROUND: Biological studies on megakaryopoiesis have been hampered by the scarcity of megakaryocytes in normal bone marrow and difficulty in long term culture. Alternatively, @entity5 cell lines with megakaryocytic differentiation potential may provide good models to counter these problems. METHODS: Leukemic cells from a @entity0 with @entity7 were put into long-term culture and established into a cell line which was designated as VGH-MK1. The VGH-MK1 cells were challenged with differentiation agents and/or cytokines, and the differentiation of these cells was examined using morphological, immunocytochemical and surface-marker studies. RESULTS: Morphologically, VGH-MK1 cells had prominent nucleoli and basophilic cytoplasm with some protrusions, but large cells were occasionally seen. Under regular culture condition, the cells had a doubling time of 36-48 hours. The cloned cell line exhibited markers characteristic of megakaryoblasts after differentiation induction. Specifically, when stimulated with @entity1 ( @entity2 ), cells became larger and had large or multinuclei. They were induced to express platelet glycoproteins GPIb ( @entity8 ), @entity3 /IIIa ( @entity3 ), and @entity4 ( @entity4 ) antigens, but not erythroid nor lymphoid markers. Platelet peroxidase (PPO) activity was also induced. @entity6 did not exhibit similar differentiation-inducing effects. In contrast, it counteracted the effects induced by @entity2 . CONCLUSIONS: An unique @entity0 @entity5 cell line, VGH-MK1, has been established here. It could be induced to exhibit some characteristics of megakaryocytic lineage, and may be an useful model for the biological studies of megakaryopoiesis.

title: Induction of megakaryocytic differentiation in a newly established XXXX @entity5 cell line by @entity1 .

answer: @entity0


abstract: BACKGROUND: In treating severe @entity1 of the esophagus and stomach, prompt diagnosis, adequate fluid resuscitation and warranted surgical intervention are the most important factors in rescue of @entity3 @entity0 . The purpose of this study was to evaluate the need for, and the advantages of, a surgical approach to treatment of such @entity1 to the upper gastrointestinal (UGI) tract, as well as to select the most suitable technique to achieve a good survival rate. METHODS: From January 1983 to December 1991, 220 @entity0 were treated for caustic ingestion injury to the UGI tract. A retrospective review of their records allowed targeting of 27 @entity0 with severe @entity1 that surgical intervention was required. In this study, peritoneal sign was taken as the key indicator for early emergency operation. The age, sex, elapsed time from injury to operation, the sort and quantity of caustic agent used, injury mechanism, clinical manifestations, alternative surgical treatment methods and causes of @entity2 were also reviewed and analyzed in this study. RESULTS: The @entity0 included 13 @entity0 and 14 @entity0 , of whom the majority were adults (96.3%) who had attempted suicide (85.2%). All of them had taken liquid corrosive agents, usually @entity4 (63%). Eighteen underwent emergency operations; the other nine received only supportive treatment, given their terminal status. The mortality rates for @entity0 with surgery and supportive treatment were 66.7% and 100%, respectively. Four @entity0 died after undergoing esophagectomy with resection of the stomach using the thoracoabdominal method. Only three of the eight @entity0 who received esophageal stripping combined with resection of the stomach through the abdomen died (37.5%). CONCLUSIONS: The time elapsed between injury and development of peritoneal sign is a good indicator of the severity and extent of the injury. When peritoneal sign manifests at a very early stage, it is an indicator that the @entity1 is very advanced in its progress and that, no matter what procedures were performed, the outcome would be the same. Yet if there were a six-hour gap then aggressive surgical management can rescue some @entity0 . It is recommended based on experience here, that when using the surgical approach, resection of the stomach with stripping of the esophagus is superior to the thoracoabdominal method.

title: Emergency surgical intervention for severe XXXX of the upper digestive tract.

answer: @entity1


abstract: Recombinant @entity0 interferon-alpha I 1 ( @entity3 ) was tested for effects on lymphocyte migration into and out of the lymph nodes of @entity1 . Chronic lymph drainage methods were used to monitor the efferent lymph of single lymph nodes of unanaesthetized animals. When @entity3 was injected into the drainage area of the lymph node, infused directly via an afferent lymphatic, or injected intravenously, a marked decrease in cell output was observed. Nanogram quantities of @entity3 produced an effect that lasted several hours. To test whether this effect was specific for lymphocytes, we first stimulated a lymph node with @entity2 so that large numbers of neutrophils and lymphocytes were present in efferent lymph. When @entity3 was then injected, the lymphocytes disappeared from efferent lymph but the neutrophils did not. Normal efferent lymph cells were labeled with radioisotopes and injected intravenously during the @entity3 induced effect. The entry of lymphocytes from the blood was significantly enhanced at a time coinciding with the suppressed cell exit in the efferent lymph. Recovery data indicated that the lymphocytes were retained temporarily in the lymph node but were not destroyed. Furthermore, the @entity0 @entity3 does not appear to be conspicuously antigenic in @entity1 . It is not yet certain whether @entity3 enhances the interactions of cells within the lymph node thereby potentiating immunologic reactions.

title: Recombinant XXXX interferon-alpha I 1 inhibits the migration of lymphocytes from lymph nodes but not into lymph nodes.

answer: @entity0


abstract: OBJECTIVE: The risk of developing @entity2 in @entity1 is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers. METHODS: In a prospective cohort of @entity0 with @entity1 , we evaluated six molecular markers: @entity5 , @entity4 , @entity7 , 20q, @entity3 and aneusomy by DNA fluorescence in situ hybridisation on brush cytology specimens. Primary study outcomes were the development of high-grade @entity6 or @entity2 . The most predictive clinical variables and markers were determined using Cox proportional-hazards models, receiver operating characteristic curves and a leave-one-out analysis. RESULTS: A total of 428 @entity0 participated (345 @entity0 ; median age 60   years) with a cumulative follow-up of 2019 @entity0 -years (median 45   months per @entity0 ). Of these @entity0 , 22 progressed; nine developed high-grade @entity6 and 13 @entity2 . The clinical variables, age and circumferential Barrett's length, and the markers, @entity5 loss, @entity3 gain and aneusomy, were significantly associated with progression on univariate analysis. We defined an 'Abnormal Marker Count' that counted abnormalities in @entity5 , @entity3 and aneusomy, which significantly improved risk prediction beyond using just age and Barrett's length. In multivariate analysis, these three factors identified a high-risk group with an 8.7-fold (95% CI 2.6 to 29.8) increased HR when compared with the low-risk group, with an area under the curve of 0.76 (95% CI 0.66 to 0.86). CONCLUSIONS: A prediction model based on age, Barrett's length and the markers @entity5 , @entity3 and aneusomy determines progression risk in @entity1 .

title: Derivation of genetic biomarkers for cancer risk stratification in XXXX : a prospective cohort study.

answer: @entity1


abstract: This study investigated whether @entity3 and quantitative changes observed with intravascular ultrasound at the most stenotic site are representative of the ultimate outcome after @entity0 . @entity2 coronary arteries (n = 40) were studied in vitro with intravascular ultrasound. From each vascular specimen, 10 corresponding intravascular ultrasound cross sections obtained before and after balloon angioplasty were selected for comparison with their histologic counterpart. Morphologic and quantitative data obtained from all cross sections were compared with data derived from the most stenotic site. The incidence of @entity3 (i.e., dissection, @entity1 , and media rupture) at the most stenotic site was lower than that seen for each vascular specimen. The sensitivity of intravascular ultrasound in detecting these morphologic features for each vascular specimen was high for dissection and media rupture (79% and 76%, respectively), and low for @entity1 (37%). After balloon angioplasty, quantitative changes seen at the most stenotic site were greater than those in all cross sections: free lumen area +58% versus +29%, media-bound area +17% versus +12%, and plaque area reduction -9% versus -6%, respectively. The increase in free lumen area was caused predominantly by media-bound area increase (81%) and to a lesser extent by plaque area decrease (19%). This study revealed that a higher incidence of @entity3 is found when the whole segment is analyzed rather than 1 single cross section at the most stenotic site. Quantitative effects of @entity0 seen with intravascular ultrasound were greater at the most stenotic site than at all cross sections.

title: Comparison of intravascular ultrasonic findings after XXXX evaluated in vitro with histology.

answer: @entity0


abstract: Eight @entity0 , aged 5 to 57 years, with uncontrolled symptomatic @entity2 for 2.5 to 41 years (mean 15) and significant @entity4 in the absence of any other apparent underlying @entity1 underwent evaluation. Incessant @entity2 was present for 0.5 to 6.0 years (mean 2.1) in 7 @entity0 . One @entity0 had an ectopic @entity2 and 7 @entity0 had an accessory atrioventricular pathway that participated in reciprocating @entity2 . Six @entity0 underwent surgery; the ectopic focus was ablated in 1 @entity0 and an accessory pathway was divided in 5 @entity0 . One @entity0 underwent open ablation of the His bundle and 1 @entity0 underwent closed-chest ablation of the atrioventricular conduction system. Myocardial biopsy specimens were obtained from 5 @entity0 , none of which yielded a specific diagnosis. Pretreatment radionuclide angiography demonstrated a mean ejection fraction (EF) of 19 +/- 9% (range 10 to 35%). Following @entity2 control a marked improvement in LV function was noted in 6 of 8 @entity0 at rest and in 1 additional @entity0 during exercise. The EF increased to 33 +/- 17% (range 16 to 56%) an average of 8 days after treatment and to 45 +/- 15% (range 22 to 67%) at late follow-up 3.5 +/- 40 months (mean 17) later (p less than 0.005). Seven @entity0 remain asymptomatic 11 to 40 months (mean 22) after the corrective procedure and have resumed normal activities. These findings suggest that chronic uncontrolled @entity2 may result in significant @entity4 , which is reversible in some cases after control of the @entity3 .

title: @entity2 -induced cardiomyopathy: a reversible form of XXXX .

answer: @entity4