abstract: OBJECTIVE: To search for predictors of placebo response in clinical trials of @entity3 for the treatment of DSM-IV-TR-defined @entity1 ( @entity1 ) in @entity0 and adults. METHOD: We used data from 2 clinical trials: (1) a 4-week, phase 3, multicenter, randomized, double-blind, forced-dose, parallel-group study of @entity0 aged 6 to 12 years with @entity1 (n = 290) and (2) a 4-week, randomized, double-blind, placebo-controlled, parallel-group, forced-dose titration study in adult subjects, aged 18-55 years with @entity1 (n = 420). Response and remission were defined using the @entity1 Rating Scale-IV and the Clinical Global Impressions-Improvement scale. RESULTS: Symptom remission was inversely correlated with baseline severity in both @entity0 and adults (P < .001), with less robust effects seen for response. The time to response and remission was delayed in adult subjects prescribed placebo versus @entity3 , while response time in @entity0 was also significantly slower with placebo versus @entity3 (P < .01). We found little evidence that demographic factors, prior pharmacotherapy, the emergence of adverse events during the trial, or changes in @entity1 symptoms from the screening to baseline assessments predicted placebo response. Certain comorbid medical symptoms reduced the response and remission rates to placebo in @entity0 (P < .001) and adults (P < .001). CONCLUSIONS: In both @entity0 and adults, baseline symptom severity was the most consistent predictor of remission with placebo while the temporal profile of response reliably differentiated placebo from medication responders. Placebo effects are most likely to be minimized in shorter trials enrolling more severely impaired subjects. The impact of medical and @entity2 comorbidities on placebo response merits further investigation. TRIAL REGISTRATION: clinicaltrials.gov identifiers NCT00556296 and NCT00334880.

title: Prediction of placebo response in 2 clinical trials of XXXX for the treatment of @entity1 .

answer: @entity3


abstract: BACKGROUND: Long-term outcomes of laparoscopic totally extraperitoneal (TEP) @entity2 performed by supervised surgical trainees are absent. METHODS: Retrospective review of TEP inguinal hernioplasties performed by trainees at our institution. RESULTS: From 1995 to 2009, a total of 1,479 @entity2 on 976 @entity0 were performed by supervised surgical trainees. The mean @entity0 age was 54 years (range 5-86). @entity0 (97%), direct defects (51%), and bilateral repairs (52%) predominated. Recurrent @entity4 compromised 17%. Four (.4%) @entity0 were converted to open surgery because of @entity7 . @entity3 consisted of urinary retention (8%), @entity6 (3%), and @entity5 (2%). Trainee participation included interns (46%), PGY-2s (10%), @entity8 s (2%), @entity9 s (3%), and PGY-5s (39%). With a mean follow-up of 6.1 years, recurrence and bothersome groin @entity1 rates were 2.6% and 1.5%, respectively. CONCLUSIONS: With adequate supervision, surgical trainees can safely perform the TEP repair with good long-term outcomes.

title: Long-term outcomes of laparoscopic totally extraperitoneal XXXX performed by supervised surgical trainees.

answer: @entity2


abstract: OBJECTIVE: To examine incidence and severity of @entity1 ( @entity1 ), and associated factors among preterm survivors (gestational age <34 weeks), admitted to a neonatal intensive care unit from 1990-2005. STUDY DESIGN: Eighteen antenatal, perinatal and postnatal factors were analyzed. The cohort was divided in four birth periods: 1990-1993 (n=661), 1994-1997 (n=726), 1998-2001 (n=723), and 2002-2005 (n=850). The Gross Motor Function Classification System was used as primary outcome measure (mean age: 32.9    5.3 months). Logistic regression analyses were used. RESULTS: @entity1 incidence decreased from 6.5% in period I, to 2.6%, 2.9% and 2.2% (P<.001) in period II-IV, respectively. Simultaneously, @entity3 ( @entity3 ) decreased from 3.3% in period I to 1.3% in period IV (P=.004). Within the total cohort (n=3287), @entity3 grade III decreased from 2.3% in period I to 0.2% in period IV (P=.003). The number of @entity0 with Gross Motor Function Classification System levels III-V decreased from period I to IV (P=.035). Independent risk factors for @entity1 were @entity3 and severe @entity2 , whereas antenatal antibiotics, presence of an arterial line, Caesarean section, and gestational age were independent protective factors. CONCLUSION: @entity1 incidence and severity decreased from 1990-1993 onward, which could be attributed to a reduction of 93% in severe @entity3 .

title: Decreasing incidence and severity of XXXX in prematurely born @entity0 .

answer: @entity1


abstract: OBJECTIVE: To examine incidence and severity of @entity1 ( @entity1 ), and associated factors among preterm survivors (gestational age <34 weeks), admitted to a neonatal intensive care unit from 1990-2005. STUDY DESIGN: Eighteen antenatal, perinatal and postnatal factors were analyzed. The cohort was divided in four birth periods: 1990-1993 (n=661), 1994-1997 (n=726), 1998-2001 (n=723), and 2002-2005 (n=850). The Gross Motor Function Classification System was used as primary outcome measure (mean age: 32.9    5.3 months). Logistic regression analyses were used. RESULTS: @entity1 incidence decreased from 6.5% in period I, to 2.6%, 2.9% and 2.2% (P<.001) in period II-IV, respectively. Simultaneously, @entity3 ( @entity3 ) decreased from 3.3% in period I to 1.3% in period IV (P=.004). Within the total cohort (n=3287), @entity3 grade III decreased from 2.3% in period I to 0.2% in period IV (P=.003). The number of @entity0 with Gross Motor Function Classification System levels III-V decreased from period I to IV (P=.035). Independent risk factors for @entity1 were @entity3 and severe @entity2 , whereas antenatal antibiotics, presence of an arterial line, Caesarean section, and gestational age were independent protective factors. CONCLUSION: @entity1 incidence and severity decreased from 1990-1993 onward, which could be attributed to a reduction of 93% in severe @entity3 .

title: Decreasing incidence and severity of @entity1 in prematurely born XXXX .

answer: @entity0


abstract: AIM OF THE STUDY: Prognostication may be difficult in comatose @entity3 survivors. Magnetic resonance imaging (MRI) is potentially useful in the prediction of neurological outcome, and it may detect acute @entity1 at an early stage. In a pilot setting we determined the prevalence and development of @entity5 using serial MRI examinations and neurological assessment. METHODS: Ten witnessed out-of-hospital @entity3 @entity0 were included. MRI was carried out approximately 2h after admission to the hospital, repeated after 24h of therapeutic @entity4 and 96 h after the arrest. The images were assessed for development of @entity5 . Neurophysiological and cognitive tests as well as a self-reported quality-of-life questionnaire, Short Form-36 (SF-36), were administered minimum 12 months after discharge. RESULTS: None of the @entity0 had @entity5 on MRI at admission. Three @entity0 developed @entity5 after therapeutic @entity4 . There was a change in the apparent diffusion coefficient, which significantly correlated with the temperature (p < 0.001). The neurophysiological tests appeared normal. The @entity0 scored significantly better on SF 36 than the controls as regards both bodily @entity2 (p = 0.023) and mental health (p = 0.016). CONCLUSIONS: MRI performed in an early phase after @entity3 has limitations, as MRI performed after 24 and 96 h revealed @entity5 not detectable on admission. ADC was related to the core temperature, and not to the volume distributed intravenously. Follow-up neurophysiologic tests and self-reported quality of life were good.

title: Repeated magnetic resonance imaging and cerebral performance after XXXX --a pilot study.

answer: @entity3


abstract: OBJECTIVES: This study assessed the safety and efficacy of thoracic endovascular aortic repair (TEVAR) in the management of aortobronchial @entity1 . METHODS: A retrospective review was performed at Emory University Hospital to identify all @entity0 who presented with an aortobronchial fistula. The diagnosis was based on clinical, radiologic, and bronchoscopic findings. @entity0 who underwent TEVAR as definitive management of these @entity1 were identified. Demographics, history of thoracic aorta pathology or intervention, type and number of endografts used, need for reoperation, and clinical and radiologic follow-up data were collected for each individual. RESULTS: Between 2000 and 2009, 11 @entity0 received TEVAR as definitive management of aortobronchial @entity1 . Technical success was achieved in 10 @entity0 (91%). Six @entity0 (55%) had previously undergone thoracic aortic surgery. A proximal type 1 endoleak developed in one @entity0 after graft deployment and required reintervention for additional graft placement. No intraoperative or 30-day deaths occurred. Postoperative clinical and radiographic assessment was a mean of 8.8 months (range, 1-40 months). For all 10 @entity0 in whom technical success was achieved at the initial operation, no endoleaks were noted at the follow-up CT scan. In addition, no @entity0 required a further intervention. CONCLUSIONS: This study represents the largest reported series on the use of TEVAR in the management of aortobronchial @entity1 . Supported by postoperative surveillance imaging and clinical evaluation, TEVAR has proven to be a safe and effective management strategy for an otherwise lethal condition. Long-term follow-up data are needed to ascertain the durability of this approach.

title: Thoracic endovascular repair as a safe management strategy for aortobronchial XXXX .

answer: @entity1


abstract: The present study is based on electron microscopical examinations of 15 conventional @entity2 , 1 clear cell @entity2 , 3 @entity6 , 2 so-called @entity1 (extraskeletal @entity4 ), 4 sacrococcygeal @entity5 , 2 ecchordoses and 1 @entity0 of tibia with features of a true peripheral @entity5 (parachordoma). The neoplastic cells from various types of @entity2 shared a number of features with nonneoplastic chondrocytes as e.g. a well-developed rough endoplasmic reticulum and microvillous cytoplasmic processes. In @entity3 , glycogen accumulation in the @entity0 cells was a prominent feature. The cells of @entity6 usually showed the characteristics of immature mesenchymal cells. In contrast, @entity5 commonly contained physaliferous cells with two types of vacuoles in their cytoplasm. The first type can be most adequately characterized as intracytoplasmic pseudoinclusions of intercellular substance, whereas the other type, glycogen-containing, single membrane-bound vacuoles most probably correspond to autophagosomes (cytolysosomes). Only vacuoles of the first type were recorded in the so-called @entity1 . They were also seen in @entity2 . In contrast, both types of vacuoles were identified in the above-mentioned tibial @entity0 which, in addition, showed even other cytological characteristics of @entity5 . The findings presented here have demonstrated distinct structural relationships between @entity1 and @entity0 . On the other hand, our observation of the uncommon tibial @entity0 indicates the possibility that @entity0 identical with @entity5 may occur at sites other than the axial skeleton.

title: A comparative ultrastructural study of XXXX , @entity1 , @entity5 and @entity5 periphericum.

answer: @entity2


abstract: The present study is based on electron microscopical examinations of 15 conventional @entity2 , 1 clear cell @entity2 , 3 @entity6 , 2 so-called @entity1 (extraskeletal @entity4 ), 4 sacrococcygeal @entity5 , 2 ecchordoses and 1 @entity0 of tibia with features of a true peripheral @entity5 (parachordoma). The neoplastic cells from various types of @entity2 shared a number of features with nonneoplastic chondrocytes as e.g. a well-developed rough endoplasmic reticulum and microvillous cytoplasmic processes. In @entity3 , glycogen accumulation in the @entity0 cells was a prominent feature. The cells of @entity6 usually showed the characteristics of immature mesenchymal cells. In contrast, @entity5 commonly contained physaliferous cells with two types of vacuoles in their cytoplasm. The first type can be most adequately characterized as intracytoplasmic pseudoinclusions of intercellular substance, whereas the other type, glycogen-containing, single membrane-bound vacuoles most probably correspond to autophagosomes (cytolysosomes). Only vacuoles of the first type were recorded in the so-called @entity1 . They were also seen in @entity2 . In contrast, both types of vacuoles were identified in the above-mentioned tibial @entity0 which, in addition, showed even other cytological characteristics of @entity5 . The findings presented here have demonstrated distinct structural relationships between @entity1 and @entity0 . On the other hand, our observation of the uncommon tibial @entity0 indicates the possibility that @entity0 identical with @entity5 may occur at sites other than the axial skeleton.

title: A comparative ultrastructural study of @entity2 , @entity1 , XXXX and @entity5 periphericum.

answer: @entity5


abstract: The present study is based on electron microscopical examinations of 15 conventional @entity2 , 1 clear cell @entity2 , 3 @entity6 , 2 so-called @entity1 (extraskeletal @entity4 ), 4 sacrococcygeal @entity5 , 2 ecchordoses and 1 @entity0 of tibia with features of a true peripheral @entity5 (parachordoma). The neoplastic cells from various types of @entity2 shared a number of features with nonneoplastic chondrocytes as e.g. a well-developed rough endoplasmic reticulum and microvillous cytoplasmic processes. In @entity3 , glycogen accumulation in the @entity0 cells was a prominent feature. The cells of @entity6 usually showed the characteristics of immature mesenchymal cells. In contrast, @entity5 commonly contained physaliferous cells with two types of vacuoles in their cytoplasm. The first type can be most adequately characterized as intracytoplasmic pseudoinclusions of intercellular substance, whereas the other type, glycogen-containing, single membrane-bound vacuoles most probably correspond to autophagosomes (cytolysosomes). Only vacuoles of the first type were recorded in the so-called @entity1 . They were also seen in @entity2 . In contrast, both types of vacuoles were identified in the above-mentioned tibial @entity0 which, in addition, showed even other cytological characteristics of @entity5 . The findings presented here have demonstrated distinct structural relationships between @entity1 and @entity0 . On the other hand, our observation of the uncommon tibial @entity0 indicates the possibility that @entity0 identical with @entity5 may occur at sites other than the axial skeleton.

title: A comparative ultrastructural study of @entity2 , @entity1 , @entity5 and XXXX periphericum.

answer: @entity5


abstract: The present study is based on electron microscopical examinations of 15 conventional @entity2 , 1 clear cell @entity2 , 3 @entity6 , 2 so-called @entity1 (extraskeletal @entity4 ), 4 sacrococcygeal @entity5 , 2 ecchordoses and 1 @entity0 of tibia with features of a true peripheral @entity5 (parachordoma). The neoplastic cells from various types of @entity2 shared a number of features with nonneoplastic chondrocytes as e.g. a well-developed rough endoplasmic reticulum and microvillous cytoplasmic processes. In @entity3 , glycogen accumulation in the @entity0 cells was a prominent feature. The cells of @entity6 usually showed the characteristics of immature mesenchymal cells. In contrast, @entity5 commonly contained physaliferous cells with two types of vacuoles in their cytoplasm. The first type can be most adequately characterized as intracytoplasmic pseudoinclusions of intercellular substance, whereas the other type, glycogen-containing, single membrane-bound vacuoles most probably correspond to autophagosomes (cytolysosomes). Only vacuoles of the first type were recorded in the so-called @entity1 . They were also seen in @entity2 . In contrast, both types of vacuoles were identified in the above-mentioned tibial @entity0 which, in addition, showed even other cytological characteristics of @entity5 . The findings presented here have demonstrated distinct structural relationships between @entity1 and @entity0 . On the other hand, our observation of the uncommon tibial @entity0 indicates the possibility that @entity0 identical with @entity5 may occur at sites other than the axial skeleton.

title: A comparative ultrastructural study of @entity2 , XXXX , @entity5 and @entity5 periphericum.

answer: @entity1


abstract: BACKGROUND: @entity1 is a @entity1 , and nodule formation. The @entity2 ( @entity2 ) and @entity5 ( @entity5 ) are very important cytokines in hepatic fibrogenesis. The aim of this study was to examine the relationship between the changes of the serum cytokines and morphological changes following common bile duct ligation in experimental @entity0 . METHODS: Common bile ducts of fifty male @entity0 were ligated and seven male @entity0 were set aside as controls. Five @entity0 each were sacrificed in 1, 2, 4, 6, 8, and 10 experimental weeks. Light microscopic studies and liver function tests were performed during the above experimental weeks. The levels of serum @entity2 and @entity5 were analyzed by ELISA. Also, @entity3 ( @entity3 ) immunohistochemical stains were performed. RESULTS: On the eighth week after common bile duct ligation, most hepatic lobular areas had been replaced by proliferated bile ducts and fibrous tissue (typical @entity4 ). Serum @entity2 levels between the control group and the common bile duct ligation group showed statistically significant changes. The @entity3 was stained at proliferated bile ducts. These findings were correlated with each other. CONCLUSION: Thus, this experiment may clarify our understanding of the mechanism in liver fibrogenesis. Also, indicated is a need to explore the therapeutic potential of these cytokines as anti-fibrotic agents.

title: Changes in serum cytokine concentration: a morphological study of liver cirrhosis induced by common bile duct ligation in XXXX .

answer: @entity0


abstract: Tuberculous and nontuberculous @entity4 is often initially misdiagnosed, delaying therapy. To identify findings which might help avoid such delays, we performed a retrospective review of all @entity0 admitted to two community hospitals over a 6-year period for @entity2 or apical segment of the lower lobe. 10 @entity0 with @entity5 and 16 with nontuberculous @entity3 were identified. Delays in initiating therapy were common to both. Most signs and symptoms were nonspecific. The mean duration of symptoms was greater in @entity5 (72 days) compared to nontuberculous @entity3 (18 days). Putrid sputum was found only in nontuberculous @entity3 (11/16). Roentgenographic features of fibronodular infiltration and @entity7 occurred only in @entity5 . Air fluid levels were seen only in nontuberculous disease (10/16). @entity6 with @entity1 neutrophils was found only in @entity0 with nontuberculous cavities. We conclude that the previously described clinical, laboratory, and roentgenographic features may be useful in correctly diagnosing @entity4 .

title: Differentiation of tuberculous from nontuberculous XXXX .

answer: @entity4


abstract: @entity1 resection is a common surgical procedure in @entity0 with @entity2 . The aim of this study is to develop and validate a computer-assisted method for selecting the most appropriate allograft from a cadaver bone bank. Fifty tibiae and femora were 3D reconstructed from computed tomography (CT) images. A transepiphyseal resection was applied to all of them in a virtual environment. A tool was developed and evaluated that compares each metaphyseal piece against all other bones in the data bank. This is done through a template matching process, where the template is extracted from the contralateral healthy bone of the same @entity0 . The method was validated using surface distance metrics and statistical tests comparing it against manual methods. The developed algorithm was able to accurately detect the bone segment that best matches the @entity0 's anatomy. The automatic method showed improvement over the manual counterpart. The proposed method also substantially reduced computation time when compared to state-of-the-art methods as well as the manual selection. Our findings suggest that the accuracy, robustness, and speed of the developed method are suitable for clinical trials and that it can be readily applied for preoperative allograft selection.

title: Allograft selection for transepiphyseal XXXX resection around the knee using three-dimensional surface registration.

answer: @entity1


abstract: RATIONALE AND OBJECTIVES: Because of the increased clinical use of computed tomography (CT) for imaging the abdominal vasculature and urinary tract, there is a need for negative contrast agents. The authors undertook this study to assess the suitability of @entity2 -coated cellulose (SCC), which is approved for use as an oral contrast agent in sonography, for use as a negative oral contrast agent in abdominal CT. MATERIALS AND METHODS: This prospective study involved 40 adult @entity0 scheduled to undergo abdominal CT for the evaluation of @entity1 . Prior to scanning, 20 subjects received 800 mL of SCC and 20 received 800 mL of water as an oral contrast agent. Imaging was performed with a multi-detector row helical scanner in two phases, according to the abdominal CT protocol used for @entity1 evaluation at the authors' institution. The first, "early" phase began an average of 15 minutes after the ingestion of contrast material; the second, "late" phase began an average of 45 minutes after the ingestion of contrast material. Blinded analysis was performed by three abdominal radiologists separately, using a three-point scale (0 = poor, 1 = acceptable, 2 = excellent) to assess the effectiveness of SCC for marking the proximal, middle, and distal small bowel. Average scores for enhancement with SCC and with water were obtained and compared. Statistical analysis was performed with a Wilcoxon signed-rank test. RESULTS: SCC was assigned higher mean scores than water for enhancement in each segment of the bowel, both on early-phase images (0.8-1.35 for SCC vs 0.6-1.1 for water) and on late-phase images (1.1-1.4 vs 0.81-0.96). Bowel marking with SCC, particularly in the jejunum and ileum, also was rated better than that with water in a high percentage of @entity0 . The differences between the scores for water and for SCC, however, were not statistically significant (P > .05). CONCLUSION: SCC is effective as a negative oral contrast agent for small bowel marking at CT.

title: Evaluation of XXXX -coated cellulose as a negative oral contrast agent for abdominal CT.

answer: @entity2


abstract: BACKGROUND: Phospholipase C-yl (PLC-yl) is known to play a critical role in cell adhesion and migration and is highly expressed in @entity0 . In the current study, we found that cells transformed by PLC overexpression (PLC-yl cells) exhibited a marked decrease in expression of the @entity5 ( @entity5 ). Here, we assessed the role of @entity5 -dependent signaling pathways in PLC-yl-dependent regulation of cell adhesion and migration. METHODS: Expression and phosphorylation of @entity5 and its functional role in PLC-yl cells were evaluated by immunoblot analysis or cell adhesion assay. The mechanism for PLC-y1-induced @entity5 downregulation was analyzed by blockage of proteosomal degradation with @entity4 . @entity5 expression was also confirmed in @entity1 tissues in which PLC-yl was highly expressed. RESULTS: @entity5 was present on @entity2 fibroblasts, where it functionally active and capable of increasing cell adhesion and migratory activity. However, PLC-yl cells significantly decreased the @entity3 -dependent effects via ubiquitination-proteosomal degradation of @entity5 . A marked decrease of @entity5 expression was confirmed in @entity1 tissues that showed high-level of PLC-yl expression. CONCLUSION: The @entity3 / @entity5 complex plays a critical role in the adhesion and migration of @entity2 fibroblasts, and its functional inactivation is associated with PLC-yl-dependent reduction of cell-matrix adhesion and this also affects cell migration.

title: Downregulation of XXXX receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells.

answer: @entity3


abstract: BACKGROUND: The incidence of @entity2 after proximal humerus @entity7 is variable, ranging from 6.2% to as much as 67%. However, it is unclear what factors might contribute to these injuries or whether they can be prevented by intraoperative nerve monitoring. QUESTIONS/PURPOSES: Therefore, using intraoperative nerve monitoring, we assessed the incidence, pattern of nerve involvement, and predisposing factors for @entity4 before and during shoulder @entity7 fixation. @entity0 AND METHODS: We used continuous intraoperative monitoring of the brachial plexus in 37 @entity0 undergoing open operative treatment of proximal humerus @entity7 . Impending intraoperative compromise of nerve function was signaled by sustained neurotonic EMG activity or greater than 50% amplitude attenuation of transcranial electrical motor evoked potentials (MEPs) (or both). When a nerve alert occurred, current surgical activity and arm and retractor position were recorded and adjustments were made to relieve @entity9 . RESULTS: The intraoperative affected nerves included axillary (46%), combined (mixed @entity10 ) (23%), radial (23%), musculocutaneous (4%), and ulnar (4%). Postoperatively, three @entity0 had @entity5 , which fully resolved within 3 weeks of surgery. Low body mass index (BMI) (22.7    2.8), history of cervical @entity3 , @entity1 , and delay in surgical treatment (14    2.9 days from @entity6 ) were associated with an increased incidence of @entity5 . CONCLUSIONS: Our observations suggest transcranial electrical MEPs are sensitive indicators of impending @entity6 to the @entity8 (or both) during open operative treatment of proximal humerus @entity7 . The use of intraoperative nerve monitoring during these procedures may be considered for the prevention of @entity4 , particularly in @entity0 with underlying cervical @entity3 , low BMI, @entity1 , and/or delay in surgical treatment greater than approximately 14 days. LEVEL OF EVIDENCE: Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

title: Nerve monitoring during proximal humeral XXXX fixation: what have we learned?

answer: @entity7


abstract: In the year 2000, the level of @entity3 ( @entity4 ) @entity2 in dermatology clinics in Europe exceeded the level of @entity2 to all other preservatives, with a prevalence of 3.5%. In the present study, cases of primary sensitization and elicitation to @entity4 due to cosmetic products were collected over an 8-month period at the Department of Dermatology, Gentofte University Hospital. The aim was to identify the products related to hand @entity1 , assess exposure to @entity4 in these products and relate the findings to results from a newly developed updated risk assessment model for contact @entity2 . Out of 24 @entity0 with a positive patch test to @entity4 , 17 @entity0 with hand @entity1 were identified. In 11 of these @entity0 , cosmetic products used in relation to the onset of the disease were shown to contain @entity4 (65%). In 8 of these 11 cases, primary sensitization was probable, 5 due to hand/body lotions and 3 due to lotions and/or liquid hand soap. Chemical analysis of 12 products showed that lotions contained 149-390 ppm of @entity4 , liquid hand soap 144-399 ppm, a rinsing cream 293 ppm and shampoos 78-79 ppm. The shampoo exposure was not of certain relevance to the @entity1 . Applying the newly developed updated risk assessment model showed that the concentrations of @entity4 in lotions of 149-390 ppm exceeded the calculated maximum acceptable exposure level for @entity4 , which would be expected to lead to sensitization in consumers using such products, as seen in the current study. The present cases and updated exposure-based risk assessment process add to the evidence and need for re-defining safe-use concentrations of @entity4 in cosmetic products.

title: XXXX : clinical experience and exposure-based risk assessment.

answer: @entity3


abstract: @entity2 ( @entity2 ), one of the most active cytotoxic antineoplastic agents, can cause @entity3 . This side effect is dose-dependent, the frequency of @entity3 being 3% at a cumulative @entity2 dose of 400 mg/m2 and 18% at 700 mg/m2. It is assumed that @entity2 , or other @entity5 derivatives, are still active when the @entity4 level is reached. In this retrospective study of 171 @entity0 with various metastatic @entity1 , the total dose of @entity2 given to the @entity0 and the reasons for withholding the treatment have been analyzed. Overall, among the 171 @entity0 treated by @entity2 -containing combination chemotherapy, 54 objective remissions (31%) were observed. Remissions were more frequent in untreated @entity0 (52%) than in previously treated @entity0 (20%). In 36 of 54 @entity0 the disease progressed before the cumulative @entity4 level was reached. @entity2 could be discontinued in only 18 @entity0 still in remission. 8 of 171 @entity0 received more than 450 mg/m2 @entity2 without @entity4 side effects being observed. Among the 171 @entity0 , @entity4 probably related to @entity6 developed in 5 cases (3%), in all cases at a level below 450 mg/m2. These results suggest that in most cases @entity2 becomes inactive before the dose-limiting cumulative @entity4 level is reached.

title: [Is the use of @entity2 ( @entity2 ) limited by its XXXX ?].

answer: @entity4


abstract: @entity2 ( @entity2 ), one of the most active cytotoxic antineoplastic agents, can cause @entity3 . This side effect is dose-dependent, the frequency of @entity3 being 3% at a cumulative @entity2 dose of 400 mg/m2 and 18% at 700 mg/m2. It is assumed that @entity2 , or other @entity5 derivatives, are still active when the @entity4 level is reached. In this retrospective study of 171 @entity0 with various metastatic @entity1 , the total dose of @entity2 given to the @entity0 and the reasons for withholding the treatment have been analyzed. Overall, among the 171 @entity0 treated by @entity2 -containing combination chemotherapy, 54 objective remissions (31%) were observed. Remissions were more frequent in untreated @entity0 (52%) than in previously treated @entity0 (20%). In 36 of 54 @entity0 the disease progressed before the cumulative @entity4 level was reached. @entity2 could be discontinued in only 18 @entity0 still in remission. 8 of 171 @entity0 received more than 450 mg/m2 @entity2 without @entity4 side effects being observed. Among the 171 @entity0 , @entity4 probably related to @entity6 developed in 5 cases (3%), in all cases at a level below 450 mg/m2. These results suggest that in most cases @entity2 becomes inactive before the dose-limiting cumulative @entity4 level is reached.

title: [Is the use of XXXX ( @entity2 ) limited by its @entity4 ?].

answer: @entity2


abstract: @entity2 ( @entity2 ), one of the most active cytotoxic antineoplastic agents, can cause @entity3 . This side effect is dose-dependent, the frequency of @entity3 being 3% at a cumulative @entity2 dose of 400 mg/m2 and 18% at 700 mg/m2. It is assumed that @entity2 , or other @entity5 derivatives, are still active when the @entity4 level is reached. In this retrospective study of 171 @entity0 with various metastatic @entity1 , the total dose of @entity2 given to the @entity0 and the reasons for withholding the treatment have been analyzed. Overall, among the 171 @entity0 treated by @entity2 -containing combination chemotherapy, 54 objective remissions (31%) were observed. Remissions were more frequent in untreated @entity0 (52%) than in previously treated @entity0 (20%). In 36 of 54 @entity0 the disease progressed before the cumulative @entity4 level was reached. @entity2 could be discontinued in only 18 @entity0 still in remission. 8 of 171 @entity0 received more than 450 mg/m2 @entity2 without @entity4 side effects being observed. Among the 171 @entity0 , @entity4 probably related to @entity6 developed in 5 cases (3%), in all cases at a level below 450 mg/m2. These results suggest that in most cases @entity2 becomes inactive before the dose-limiting cumulative @entity4 level is reached.

title: [Is the use of @entity2 ( XXXX ) limited by its @entity4 ?].

answer: @entity2


abstract: Proteins with internal repeats are highly conserved among budding @entity0 . In this study, the isolation of two proteins with internal repeats (PIR) genes, i.e. PpPIR1 and PpPIR2, from the methylotrophic @entity0 @entity3 has been reported. The @entity5 and @entity4 genes' open reading frames were found to contain 1068 and 972 bases, respectively. The sequence homology search showed a homologous conserved repeat of PIR @entity0 block (SQIGDGQIQATT) in both proteins. The PIR @entity0 block was present eight times in the PpPir1p and four times in the PpPir2p proteins. Both proteins showed conserved @entity1 (Q) and @entity2 (D) in the repeated sequences, indicating a possible alkali-sensitive b1,3-glucan ester linkage. The fusion constructs of PpPir1-2p and enhanced green fluorescent protein (EGFP) were developed for @entity0 cell surface display. The immunofluorescence assay showed uniform localization of EGFP protein on the @entity3 cell surface in all fusion constructs. Furthermore, new vectors were developed for recombinant protein secretion in @entity3 , utilizing the pre-pro signal of PpPir1p protein. Efficient processing of the signal sequence was observed from EGFP and human a1-antitrypsin (AAT) fusion constructs and recombinant protein secretion was obtained in the culture supernatant.

title: Isolation of XXXX PIR genes and their utilization for cell surface display and recombinant protein secretion.

answer: @entity3


abstract: OBJECTIVE: To compare the resorption characteristics of dorsal onlay cartilage autografts from the septum, auricle, and rib. METHODS: Fourteen New Zealand white @entity1 underwent harvesting of equal-sized septal, auricular, and costal cartilage grafts free of perichondrium. All autografts were implanted subcutaneously on the nasal dorsum and then removed after 3 months. Graft mass, chondrocyte density, and histologic features from @entity3 - @entity4 -stained sections were compared before and 3 months after implantation. RESULTS: At 3 months after implantation, septal cartilage grafts averaged 30.8% resorption by weight, followed by auricular (23.1%) and costal (7.6%) cartilage. All 3 groups demonstrated similar changes in chondrocyte density and minor @entity2 at 3 months. There was no evidence of @entity0 or inflammatory changes in any of the specimens. CONCLUSIONS: Although the septum is often the preferred source of autogenous cartilage for nasal reconstruction, short-term resorption of septal cartilage appears to be higher for dorsal onlay grafts. The low resorption of costal cartilage may be due in part to its compact shape compared with septal and auricular cartilage. It remains to be seen whether these differences in resorption persist in the long term.

title: Dorsal onlay cartilage autografts: comparing resorption in a XXXX model.

answer: @entity1


abstract: BACKGROUND: Caspase-cleaved @entity4 (CCCK-18) is released during apoptosis. Serum CCCK-18 concentrations are associated with prognosis of some @entity5 . We investigated the potential relationships between serum CCCK-18 concentrations and disease severity and long-term clinical outcomes after @entity3 . METHODS: Serum CCCK-18 concentrations were determined in a total of 102 @entity0 and 102 controls. Multivariate models were used to predict high concentration of CCCK-18 and 6-month clinical outcomes. The predictive values were evaluated based on areas under receiver operating curve. RESULTS: Compared with controls, serum CCCK-18 concentrations were increased in @entity0 (245.8  108.3U/l vs. 23.6  18.1U/l, P<0.001). National Institute of Health @entity1 Scale scores [odds ratio (OR), 1.164; 95% confidence interval (CI), 1.027-1.320; P=0.003] and @entity2 volumes (OR, 1.079; 95% CI, 1.018-1.205; P=0.008) were independent predictors of high concentration of CCCK-18. CCCK-18 was identified as an independent predictor of 6-month mortality (OR, 1.019; 95% CI, 1.010-1.038; P=0.013) and 6-month unfavorable outcome (OR, 1.017; 95% CI, 1.008-1.029; P=0.032) and possessed high predictive values. CONCLUSION: Increased serum CCCK-18 concentrations are associated with disease severity and clinical outcomes, suggesting that CCCK represent a novel prognostic predictive biomarker after @entity3 .

title: Predictive value of serum caspase-cleaved @entity4 concentrations after acute XXXX .

answer: @entity3


abstract: BACKGROUND: Caspase-cleaved @entity4 (CCCK-18) is released during apoptosis. Serum CCCK-18 concentrations are associated with prognosis of some @entity5 . We investigated the potential relationships between serum CCCK-18 concentrations and disease severity and long-term clinical outcomes after @entity3 . METHODS: Serum CCCK-18 concentrations were determined in a total of 102 @entity0 and 102 controls. Multivariate models were used to predict high concentration of CCCK-18 and 6-month clinical outcomes. The predictive values were evaluated based on areas under receiver operating curve. RESULTS: Compared with controls, serum CCCK-18 concentrations were increased in @entity0 (245.8  108.3U/l vs. 23.6  18.1U/l, P<0.001). National Institute of Health @entity1 Scale scores [odds ratio (OR), 1.164; 95% confidence interval (CI), 1.027-1.320; P=0.003] and @entity2 volumes (OR, 1.079; 95% CI, 1.018-1.205; P=0.008) were independent predictors of high concentration of CCCK-18. CCCK-18 was identified as an independent predictor of 6-month mortality (OR, 1.019; 95% CI, 1.010-1.038; P=0.013) and 6-month unfavorable outcome (OR, 1.017; 95% CI, 1.008-1.029; P=0.032) and possessed high predictive values. CONCLUSION: Increased serum CCCK-18 concentrations are associated with disease severity and clinical outcomes, suggesting that CCCK represent a novel prognostic predictive biomarker after @entity3 .

title: Predictive value of serum caspase-cleaved XXXX concentrations after acute @entity3 .

answer: @entity4


abstract: The @entity0 genome encodes a single Hand bHLH transcription factor. Either @entity2 or a @entity2 deletion causes partially penetrant defects in viability and gonadogenesis. Dead embryos and young larvae are often misshapen at the posterior end. Our primary focus has been the role of @entity2 in gonadogenesis. Wild-type @entity0 has two somatic gonadal precursors and two primordial germ cells in stereotyped positions within its four-celled gonadal primordium. The @entity2 gene affects the presence and position of both the somatic gonadal precursors and primordial germ cells within the primordium, but does not appear to have any role in later gonadogenesis. @entity2 probably acts within the somatic gonadal precursors or their mesodermal predecessors; defects in primordial germ cells and germ line appear to be secondary. In @entity2 mutants, somatic gonadal precursors are generated normally, but are not maintained properly and sometimes die. A similar role in controlling the maintenance of precursor fates has been described for other genes governing early organogenesis, including the @entity1 Hand gene hands off. We also report the discovery of two genes, ehn-1 and @entity3 , that have overlapping functions with @entity2 in embryogenesis and gonadogenesis.

title: The XXXX Hand gene controls embryogenesis and early gonadogenesis.

answer: @entity0


abstract: Epidermal cells in the root of @entity0 seedling differentiate either as hair or non-hair cells, while in the hypocotyl they become either stomatal or elongated cells. WEREWOLF (WER) and @entity3 ( @entity3 ) are positive regulators of non-hair and elongated cell development. @entity4 ( @entity4 ) is a positive regulator of hair cell development in the root. We show that WER, @entity3 and @entity4 are expressed and active during the stages of embryogenesis when the pattern of cells in the epidermis of the root-hypocotyl @entity2 forms. @entity3 is first expressed in the future epidermis in the heart stage embryo and its expression is progressively restricted to those cells that will acquire a non-hair identity in the transition between torpedo and mature stage. The expression of @entity3 at the heart stage requires WER function. WER and @entity4 are transiently expressed throughout the root epidermal layer in the torpedo stage embryo when the cell-specific pattern of @entity3 expression is being established in the epidermis. We also show that WER positively regulates @entity4 transcription and @entity3 negatively regulates WER transcription in the mature embryo. We propose that the restriction of @entity3 to the future non-hair cells in the root epidermis can be correlated with the activities of WER and @entity4 during torpedo stage. In the @entity1 we show that WER controls @entity3 expression. We also provide evidence indicating that @entity4 may also regulate @entity3 expression in the hypocotyl.

title: Epidermal patterning genes are active during embryogenesis in XXXX .

answer: @entity0


abstract: The aim of the study was to analyze the association between prenatal environmental @entity1 smoke exposure (ETS) and @entity0 anthropometric parameters at birth such birth weight, length, head and chest circumference. The study population consisted of 107 pregnant @entity0 from Lodz district as the part of Polish Mother and @entity0 Cohort study. The @entity0 prenatal ETS exposure was assessed based on questionnaire with mothers and @entity2 level in saliva collected three times in pregnancy. The level of @entity2 in biological samples was analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS ESI+). About 35% of the @entity0 were prenatally exposed to ETS. The birth weight of the @entity0 prenatally exposed to ETS was 335 g lower than the birth weight of non-exposed newborns p < 0.001 after adjustment for: maternal educational level, marital status, prepregnancy weight, @entity0 gender, and gestational age. The same refers to @entity0 length and chest circumference (coef. -1.1 cm; p = 0.03 and coef. -1.3 cm; p = 0.002 respectively). Taking into account the negative effect of prenatal exposure to ETS, more efforts need to be taken to eliminate @entity0 ETS exposure.

title: [Impact of prenatal environmental XXXX smoke exposure on birth parameters].

answer: @entity1


abstract: Smoking @entity1 is a problem which is concerned with all environments including disabled @entity0 . It is involved in increasing a lot of diseases, especially intensify disability and earlier passing away. The main objective of this thesis was the assessment of the problem of being addicted to smoke @entity1 among disabled countrymen and the identification of the social and demographic factors, which have influence on smoking @entity1 by disabled @entity0 . The researches were done among disabled @entity0 lived in villages of Kalisz. The questionnaire of survey was an instrument of the research. Demographic features such as: gender, age, education, marital status, cause and the age of becoming disabled were analyzed. 175 disabled @entity0 (69 @entity0 and 96 @entity0 ) with the 18 - 45 age group were examined. Chi square test was capitalize on the statistical compilation. 5% mistake of deduction was accepted (p < 0.05). The statistical analysis showed dependence of smoking cigarettes on gender, cause and age of becoming disabled (p < 0.05). The identification of factors affected by smoking cigarettes allowed to isolate the smaller groups of disabled @entity0 to whom programs including healthy way of life should be promoted.

title: [Social and demographic factors v smoking XXXX among disabled countrymen].

answer: @entity1


abstract: To allow vaccination irrespective of HLA type, DNA vaccines encoding full-length antigens are required. However, here, we demonstrate that the immunogenicity of DNA vaccines encoding the full-length @entity4 ) @entity6 E7 and E6 proteins is highly reduced compared to vaccines encoding only the immunodominant epitope. Furthermore, the low remaining immunogenicity is essentially lost for both E7 and E6 when a nononcogenic "gene-shuffled" variant is utilized. To address these issues, we tested whether alterations in transgene design can restore the immunogenicity of full-length and gene-shuffled DNA vaccines. Remarkably, genetic fusion of E7 with @entity1 toxin fragment C (TTFC) resulted in a dramatic increase in immunogenicity both for the full-length and the gene-shuffled version of E7. Moreover, the TTFC fusion vaccines were more immunogenic than a vaccine encoding a fusion of E7 and mycobacterial @entity5 protein-70, which has recently been tested in a clinical trial. Interestingly, vaccination with these TTFC fusion vaccines also resulted in extremely persistent T-cell responses. The E7-specific CD8(+) T cells induced by TTFC fusion vaccines were functional in terms of @entity3 production, formation of immunological memory, in vivo cytolytic activity and @entity0 eradication. Finally, we show that genetic fusion with TTFC also improves the immunogenicity of a gene-shuffled E6 DNA vaccine. These data demonstrate that genetic fusion with @entity1 toxin fragment C can dramatically improve the immunogenicity of full-length and gene-shuffled DNA vaccines. The DNA fusion vaccines developed here will be evaluated for the treatment of @entity2 in future studies.

title: Preclinical development of highly effective and safe DNA vaccines directed against XXXX E6 and E7.

answer: @entity6


abstract: BACKGROUND: The optimal treatment for @entity1 ( @entity1 ) remains controversial. In Sweden, the standard treatment is unthreaded fixation over the physis, with the purpose to permit continued growth of the femoral neck. The aim of the present study was to verify and quantify longitudinal growth of the femoral neck after in situ pinning with the Hansson hook-pin. METHODS: We performed a retrospective study of 54 @entity0 treated with the Hansson hook-pin for @entity1 between 2001 and 2009. The immediate postoperative radiograph and the radiograph after physeal closure (mean interval, 34 mo) were analyzed. Because the smooth Hansson hook-pin only has a grip fixation in the epiphysis, the femoral neck growth was determined as the difference in nail protrusion from the lateral cortex between the 2 radiographs. The femoral neck offset was also measured in all radiographs. RESULTS: Significant longitudinal growth occurred both in the slipped and the prophylactically treated contralateral hip by mean 7.1 mm (P<0.001) and 10.0 mm (P<0.001), respectively. There was no difference in growth between genders and no correlation between the amount of longitudinal growth and slip severity (range, 4.0 to 71,6 degrees; mean 27.3 degrees). Young @entity0 (less than 11 y) grew more than older @entity0 (more than 14 y), 12.1 vs. 4.2 mm, P=0.002. The femoral offset increased by mean 16% from mean 30.0 to 35.2 mm (P<0.001). The longitudinal growth of the femoral neck correlated with the increase in femoral offset (R=0.51, P<0.001). CONCLUSIONS: Unthreaded fixation of @entity1 with the Hansson hook-pin allows continued growth of the femoral neck. The remaining growth enables the @entity0 to achieve an almost anatomic offset of the hip. This is essential to optimize the abduction forces that stabilize the pelvis during gait. Future studies need to establish whether the longitudinal growth also results in improved remodelling of the proximal femur. LEVEL OF EVIDENCE: Level III-retrospective comparative study.

title: Unthreaded Fixation of Slipped Capital XXXX Leads to Continued Growth of the Femoral Neck.

answer: @entity1


abstract: BACKGROUND: Restoration of flexion in the elbow is the priority in the management of @entity1 . Current techniques of reconstructions, combining both nerve grafting and nerve transfer, allow more extensive repair, with additional targets: shoulder, elbow extension, hand. The transfer of intercostal nerves onto the nerve of the triceps long head is used to restore elbow extension. The aim of this retrospective study is to evaluate the results of this procedure, in total @entity2 with uninjured C5 and C6 roots. METHODS: Eleven @entity0 with total @entity1 were reviewed 24 months in average after intercostal nerves transfer. The average age of the @entity0 was twenty-nine years. The average time to surgery after occurrence of the injury was 5 months. Triceps re-innervation and strength of elbow extension were evaluated. RESULTS: The averaged time required for triceps re-innervation after intercostal nerve transfer was 9 months. Seven @entity0 achieved M4 elbow extension according to the Medical Research Council grading system. Two @entity0 achieved M3 elbow extension. Two @entity0 had poor results (M2 and M0). DISCUSSION AND CONCLUSIONS: Transfer of intercostal nerves onto the nerve of the triceps long head is a reliable procedure for the restoration of elbow extension in total @entity2 .

title: Reanimation of elbow extension with intercostal nerves transfers in total XXXX .

answer: @entity2


abstract: PURPOSE: To evaluate the suitability of an improved version of an automatic segmentation method based on geodesic active regions (GAR) for segmenting cerebral vasculature with @entity2 from 3D x-ray reconstruction angiography (3DRA) and time of flight magnetic resonance angiography (TOF-MRA) images available in the clinical routine. METHODS: Three aspects of the GAR method have been improved: execution time, robustness to variability in imaging protocols, and robustness to variability in image spatial resolutions. The improved GAR was retrospectively evaluated on images from @entity0 containing @entity1 in the area of the @entity3 and imaged with two modalities: 3DRA and TOF-MRA. Images were obtained from two clinical centers, each using different imaging equipment. Evaluation included qualitative and quantitative analyses of the segmentation results on 20 images from 10 @entity0 . The gold standard was built from 660 cross-sections (33 per image) of vessels and @entity2 , manually measured by interventional neuroradiologists. GAR has also been compared to an interactive segmentation method: isointensity surface extraction (ISE). In addition, since @entity0 had been imaged with the two modalities, we performed an intermodality agreement analysis with respect to both the manual measurements and each of the two segmentation methods. RESULTS: Both GAR and ISE differed from the gold standard within acceptable limits compared to the imaging resolution. GAR (ISE) had an average accuracy of 0.20 (0.24) mm for 3DRA and 0.27 (0.30) mm for TOF-MRA, and had a repeatability of 0.05 (0.20) mm. Compared to ISE, GAR had a lower qualitative error in the vessel region and a lower quantitative error in the @entity2 region. The repeatability of GAR was superior to manual measurements and ISE. The intermodality agreement was similar between GAR and the manual measurements. CONCLUSIONS: The improved GAR method outperformed ISE qualitatively as well as quantitatively and is suitable for segmenting 3DRA and TOF-MRA images from clinical routine.

title: Automated segmentation of cerebral vasculature with XXXX in 3DRA and TOF-MRA using geodesic active regions: an evaluation study.

answer: @entity2


abstract: With the growing number of biotechnology products and drug delivery systems entering preclinical and clinical studies, pharmacological imaging studies with PET play an increasingly significant role. Such studies often require investigation of slow and complex pharmacokinetics (PK). This suggests labeling of the drug candidate with radionuclides that have long physical half-lives. Among the currently available PET positron emitters,        I has the longest physical half-life (4.2 days). This, combined with the well-investigated behavior of @entity2 in vivo, makes        I very attractive for pharmacological studies. However, the high energy of the positrons emitted by        I and the presence of single photons in the        I emission can potentially introduce limitations in the quantitative analysis of the images. The objective of this research was to determine whether the use of        I as a PET label provides data quality suitable for PK studies. The study was carried out using MicroPET P4 scanner ( @entity3 ). Spatial resolution, count-rate performance, sensitivity and scatter fraction were measured using a line source and a cylindrical phantom. Model animal studies in @entity1 and @entity4 were carried out using @entity0 recombinant proteins. The proteins were labeled with        I, up to 185 MBq/mg. The transaxial and axial spatial resolutions in the center of the camera were satisfactory and higher for OSEM3D/MAP than FORE-2DFBP (FWHM 2.52 vs 3.31 mm, and 3.10 vs 3.69 mm). Linearity of the true coincidence count-rate was observed up to 44 MBq. Animal studies demonstrated excellent delineation and resolution of even very small organs. At optimal doses, 2-10 MBq per animal for rodents and 4-10 MBq per kg of body weight for larger animals, the quality of numerical data was appropriate for PK analysis in all experimental timeframes from minutes (dynamic studies) to 10 days. Overall, the data suggest that        I is an excellent label for quantitative pharmacological PET imaging studies.

title: XXXX -124 as a label for pharmacological PET imaging.

answer: @entity2


abstract: OBJECT: This study was conducted both prospectively and retrospectively at one center over a period of 8 years. The population consisted of all @entity0 with both an age 18 years or younger and a diagnosed penetrating @entity2 (PMI) during the study interval. The authors analyzed factors determining outcome and demographic trends in this population, and they compared them with those in the more developed world. METHODS: Fifty-one @entity0 were the victims of armed conflict, although no one was directly a party to any battle. This mechanism of injury is in strong opposition to data in the literature from developed countries, in which most missile injuries are the result of suicide or homicide or are even sports related. Moreover, all previous studies on the pediatric population have considered only injuries from gunshots, but authors of the current study have included injuries from other penetrating missiles as well. RESULTS: On cross tabulation analysis using the chi-square test, the factors shown to correlate with outcome included the Glasgow @entity4 Scale (GCS) score, @entity5 , @entity0 age, hemodynamic status, and @entity1 . On multinomial regression analysis, the two strongest predictors of @entity3 were GCS score and @entity5 . The GCS score and hemodynamic status were the strongest predictors of disability. CONCLUSIONS: There was no difference in the prognostic factors for PMI between developing or more developed countries. Glasgow @entity4 Scale score, @entity5 , and hemodynamic status were the strongest predictors of outcome. In conflict zones in developing countries the victims were mostly innocent bystanders, whereas in the more developed countries homicides and suicides were the leading etiological factors.

title: XXXX to the pediatric brain in conflict zones.

answer: @entity2


abstract: OBJECT: The authors present their experience in the surgical treatment of @entity3 by @entity1 . The pitfalls and advantages of the surgical technique are discussed, along with the long-term clinical results in 48 consecutive cases. METHODS: Forty-eight consecutive @entity0 in whom @entity3 was diagnosed between 1990 and 2009 were treated with frontal @entity5 and @entity6 . Of these @entity0 , 38 (79%) were @entity0 and 10 (21%) were @entity0 . The age at the time of surgical treatment ranged between 4 and 42 months (mean    SD 11.4    8.7 months). The average follow-up period was 5.5    4.2 years (range 5 months-19 years). The preoperative and latest postoperative photographs of the @entity0 were evaluated for the following features: 1) shape of the forehead; 2) @entity7 ; and 3) temporal @entity4 . Scores of 0, 1, or 2 were assigned for each item: 0 was normal, 1 meant moderate @entity2 , and 2 denoted severe @entity2 . RESULTS: In the early postoperative period, no complications were documented. The average hospitalization period was 4 days. Follow-up radiographs or 3D CT scans were obtained at regular intervals. The mean preoperative scores for the evaluated items were 1.38    0.49 for the shape of the forehead, 1.33    0.48 for @entity7 , and 1.7    0.46 for the temporal @entity4 . The mean postoperative scores were 0.06    0.24 for the shape of the forehead, 0.21    0.4 for @entity7 , and 0.67    0.48 for the temporal @entity4 . Overall, the total preoperative score dropped from 4.4 to 0.93 postoperatively (p < 0.05). All the @entity0 were contented with the cosmetic results. CONCLUSIONS: Early detection and treatment of metopic suture synostosis has a significant, favorable influence on the outcomes. Good understanding of the structural abnormality and the pathophysiological mechanisms of the possible complications is very important for performing proper surgical reconstruction.

title: Surgical treatment of XXXX : technique and long-term results in 48 cases.

answer: @entity3


abstract: AIMS: To investigate the course of @entity1 defined by Research Diagnostic Criteria for @entity4 ( @entity6 / @entity5 ) over a period of 5 years, and to identify prognostic factors from baseline data. METHODS: Subjects were 155 consecutive @entity0 and 80 community cases identified from an age-stratified representative population sample; all met the primary selection criterion of reporting @entity1 in the @entity2 ( @entity2 ) or masticatory muscles. The 2 groups were combined to yield a total sample of 235 subjects (50 male, 185 female; mean age = 39 years). Subjects were evaluated at baseline, 1 year, 3 years, and 5 years by trained examiners using standardized, reliable methods. Psychological and behavioral factors were assessed by self report. RESULTS: According to @entity6 / @entity5 criteria, 50 (31%) of the 165 subjects presenting with @entity1 ( @entity1 ) at baseline continued to have their disorder over a period of 5 years; 55 (33%) remitted, and 60 (36%) were recurrent cases. Bivariate statistics and multivariate logistic regression analyses indicated that baseline @entity1 frequency, number of painful palpation sites, and total number of body sites with @entity1 were significant predictors of persistent vs remitted and recurrent cases. No predictors that distinguished remission vs recurrence could be identified. Thirty subjects from the 70 without a diagnosis of @entity1 at baseline developed a new @entity1 . A high baseline @entity3 score (without @entity1 items) was a significant risk factor for onset of @entity1 . CONCLUSION: Muscle disorders classified by @entity6 / @entity5 are predominantly chronic or fluctuating @entity1 conditions, with a modest probability (31%) of remission.

title: Longitudinal outcome of XXXX : a 5-year epidemiologic study of muscle disorders defined by research diagnostic criteria for @entity4 .

answer: @entity4


abstract: AIMS: To investigate the course of @entity1 defined by Research Diagnostic Criteria for @entity4 ( @entity6 / @entity5 ) over a period of 5 years, and to identify prognostic factors from baseline data. METHODS: Subjects were 155 consecutive @entity0 and 80 community cases identified from an age-stratified representative population sample; all met the primary selection criterion of reporting @entity1 in the @entity2 ( @entity2 ) or masticatory muscles. The 2 groups were combined to yield a total sample of 235 subjects (50 male, 185 female; mean age = 39 years). Subjects were evaluated at baseline, 1 year, 3 years, and 5 years by trained examiners using standardized, reliable methods. Psychological and behavioral factors were assessed by self report. RESULTS: According to @entity6 / @entity5 criteria, 50 (31%) of the 165 subjects presenting with @entity1 ( @entity1 ) at baseline continued to have their disorder over a period of 5 years; 55 (33%) remitted, and 60 (36%) were recurrent cases. Bivariate statistics and multivariate logistic regression analyses indicated that baseline @entity1 frequency, number of painful palpation sites, and total number of body sites with @entity1 were significant predictors of persistent vs remitted and recurrent cases. No predictors that distinguished remission vs recurrence could be identified. Thirty subjects from the 70 without a diagnosis of @entity1 at baseline developed a new @entity1 . A high baseline @entity3 score (without @entity1 items) was a significant risk factor for onset of @entity1 . CONCLUSION: Muscle disorders classified by @entity6 / @entity5 are predominantly chronic or fluctuating @entity1 conditions, with a modest probability (31%) of remission.

title: Longitudinal outcome of @entity4 : a 5-year epidemiologic study of muscle disorders defined by research diagnostic criteria for XXXX .

answer: @entity4


abstract: @entity12 is an uncommon maternal auto-antibody-associated disease characterized by cutaneous, cardiac, hepatic, hematological, neurological, and @entity3 . A retrospective study was performed to review clinical manifestations, investigation results, outcomes of @entity12 @entity0 and their mothers at the Department of Pediatrics, Siriraj Hospital during 1993 to 2008. Seventeen @entity12 @entity0 (10 @entity0 and seven @entity0 ) were identified. Cutaneous, cardiac, hepatobiliary, and hematological involvement was found in 70.6%, 64.7%, 52.9%, and 35.3% of @entity0 , respectively. @entity2 were erythematous patches (91.7%), subacute @entity9 (50%), petechiae (41.7%), persistent @entity6 marmorata (16.7%), and discoid lesions (8.3%). @entity10 was found in nine cases, and @entity8 were found in nine cases. All sera of @entity0 were positive for antinuclear antibodies. Patients (87.5%) showed positive antiRo/SSA, and 50% had positive antiLa/ @entity11 antibodies. Most @entity12 mothers (64.7%) were asymptomatic. Five mothers were diagnosed with @entity5 , and one mother was diagnosed with @entity7 . All maternal sera was positive for antinuclear antibodies and antiRo/SSA antibody. Seven @entity0 required pacemaker implantation. The mortality rate was 11.8%, caused by @entity4 and @entity1 . Antinuclear antibody tests should be used as one of the screening tests in mothers or @entity0 suspected of having @entity12 .

title: XXXX : clinical character, investigation, and outcome.

answer: @entity12


abstract: BACKGROUND: Surface proteins are a key to a deeper understanding of the behaviour of Gram-positive bacteria interacting with the @entity0 gastro-intestinal tract. Such proteins contribute to cell wall synthesis and maintenance and are important for interactions between the bacterial cell and the @entity0 host. Since they are exposed and may play roles in pathogenicity, surface proteins are interesting targets for drug design. RESULTS: Using methods based on proteolytic "shaving" of bacterial cells and subsequent mass spectrometry-based protein identification, we have identified surface-located proteins in @entity6 . In total 69 unique proteins were identified, few of which have been identified and characterized previously. 33 of these proteins are predicted to be cytoplasmic, whereas the other 36 are predicted to have surface locations (31) or to be secreted (5). Lipid-anchored proteins were the most dominant among the identified surface proteins. The seemingly most abundant surface proteins included a membrane protein with a potentially shedded extracellular sulfatase domain that could act on the @entity2 groups in mucin and a lipid-anchored @entity5 reductase that could contribute to generation of reactive @entity1 species. CONCLUSIONS: The present proteome analysis gives an experimental impression of the protein landscape on the cell surface of the pathogenic bacterium E. faecalis. The 36 identified secreted (5) and surface (31) proteins included several proteins involved in cell wall synthesis, @entity4 -regulated processes, and transport of solutes, as well as proteins with unknown function. These proteins stand out as interesting targets for further investigation of the interaction between @entity3 and its environment.

title: Identification of surface proteins in XXXX .

answer: @entity6


abstract: Over the past decade, eastern Europe has experienced a resurgence of @entity2 . A recent outbreak in Serbia, Yugoslavia, from December 2001 to January 2002, involving 309 @entity0 , revealed many of the causes for this reemergence. Epidemiological investigations indicate that the immediate cause of the recent outbreak was the consumption of smoked sausages produced by a small slaughterhouse or meat processor. However, failure of in-house meat inspection procedures and quality assurance as well as oversight by official veterinary control were also responsible. Further analysis of this breakdown in the food safety net revealed additional general factors that have yielded a seriously deficient veterinary control system, and these are factors that are relevant to the problems experienced throughout eastern Europe and other regions. The recent civil war that led to the breakup of the former Federation of Yugoslavia resulted in severe economic and demographic changes, including high inflation and external economic sanctions. This led to (1) the loss of large numbers of experienced @entity3 and their replacement with inexperienced personnel, (2) a change in the @entity1 industry with reduction in the number of large establishments with in-house inspection and replacement with more than 1,000 small abattoirs, too small to afford full-time in-house inspection, and (3) an increase in smallholder @entity1 farming with reduced government oversight to ensure high standards in @entity1 -rearing practices (infection risk management). The consequences of these events have been a 300% increase in Serbian @entity1 infection and a concomittant large increase in @entity0 outbreaks. Before 1990, @entity1 @entity2 in Serbia was confined to 4 small districts, but today about one third of the Republic is considered endemic for @entity2 . The reemergence of @entity2 in Serbia illustrates the ability of this zoonosis to "leak" through a poorly maintained food safety barrier and the vulnerability of effective veterinary control to national and international events.

title: Social, political, and economic factors responsible for the reemergence of XXXX in Serbia: a case study.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is prevalent in the emergency departments. Nearly 60% of them may lead to @entity3 . A complete color-flow duplex ultrasound (CFDU), performed by the radiologists, is the most common diagnostic method used to detect @entity2 . A limited B-mode compression technique (BMCT) can also be useful for the emergency specialists visiting suspicious cases. OBJECTIVES: The purpose of this study was to compare the sensitivity, specificity, and accuracy of a BMCT done by emergency medicine residents with that of a CFDU in diagnosing the proximal @entity2 of lower extremities. METHODS: This prospective study was conducted on 74 @entity0 (41 @entity0 and 33 @entity0 ) presenting with @entity1 and swollen lower limbs in the emergency department of Imam Khomeini Hospital. First, the affected lower extremity was examined by a BMCT carried out by one of the 2 emergency medicine residents. Then, the CFDU was performed by a radiologist blinded to the results of the BMCT. The sensitivity, specificity, and accuracy of the BMCT were compared with that of the CFDU as a gold standard. RESULTS: The mean age of the @entity0 was 55.16    17.4 years. Positive results were reported in 35 @entity0 (47.3%) using the 2 tests. Compared with CFDU, BMCT had a sensitivity, specificity, accuracy, positive predictive values, and negative predictive values of 100%. CONCLUSION: These findings suggest that BMCT performed by the emergency medicine specialists to diagnose proximal @entity2 of lower extremities is not only an acceptable method but also less time-consuming when compared with CFDU.

title: The accuracy of limited B-mode compression technique in diagnosing XXXX in lower extremities.

answer: @entity2


abstract: OBJECTIVE: The purpose of this study was to describe the findings of MR imaging and radiographic changes that occur in osseous structures adjacent to soft-tissue @entity1 of the extremities and to correlate them with @entity0 symptomatology, the size of the @entity1 , and their proximity to adjacent bone. MATERIALS AND METHODS: We retrospectively reviewed the radiographs and MR images of 35 @entity0 with soft-tissue @entity1 of the extremities. The pattern and extent of the osseous change were categorized as periosteal, cortical, or medullary. Symptomatology, size, and proximity of the @entity1 to the adjacent bone were compared with the presence or absence of osseous change. Statistical analysis was performed using the Student's t test. RESULTS: Osseous change was noted on radiographs in 13 (37%) of 35 @entity0 and on MR images in 11 (31%) of 35 @entity0 with a total of 14 @entity0 (40%) showing osseous change on at least one study. Periosteal change was present in eight (23%) of 35 @entity0 ; cortical change, in 11 (31%) of 35 @entity0 ; and medullary change, in 10 (29%) of 35 @entity0 . Direct contact between the soft-tissue @entity1 and the adjacent bone was seen in 13 of 14 @entity0 with osseous change. In those @entity0 without osseous change, the average distance between the soft-tissue @entity1 and bone was 1.06 cm (range, 0-4 cm). No correlation was found between symptoms and the presence of osseous change. CONCLUSION: Soft-tissue @entity1 of the extremities frequently result in adjacent osseous change that can be categorized as either periosteal, cortical, or medullary. Only medullary changes correspond with @entity1 size, whereas all three categories of change correlate with the proximity of the @entity1 to the adjacent bone. The presence of osseous change does not correlate with @entity0 symptomatology.

title: Osseous change adjacent to soft-tissue XXXX of the extremities: correlation with lesion size and proximity to bone.

answer: @entity1


abstract: Emergence @entity2 (EA) is a postanesthetic problem that interferes with a @entity0 's recovery and presents a challenge in terms of assessment and management. In this prospective cohort study, we sought to determine the incidence of EA, evaluate factors associated with and predictive of EA, and describe associated outcomes in healthy @entity0 . @entity0 aged 3-7 yr who were undergoing general anesthesia for elective outpatient procedures were included. All perioperative care was documented, and @entity1 in the postanesthesia care unit were recorded. Parents completed the Behavioral Style Questionnaire for 3- to 7-yr-olds. Five-hundred-twenty-one @entity0 were studied, of whom 96 (18%) had EA. Agitation lasted up to 45 min in some cases (range, 3-45 min; mean, 14 +/- 11 min), required pharmacologic intervention in 52% of @entity0 , and was associated with a prolonged postanesthesia care unit stay (117 +/- 66 min versus 101 +/- 61 min for nonagitated @entity0 ; P = 0.02). Ten factors were found to be associated with EA, including age, previous surgery, adaptability, ophthalmology and otorhinolaryngology procedures, @entity3 , @entity4 , @entity3 / @entity4 , analgesics, and time to awakening. Of these, otorhinolaryngology procedures, time to awakening, and @entity4 were shown to be independent risk factors. IMPLICATIONS: @entity0 may become agitated after general anesthesia. This study describes several factors that may increase the risk for @entity2 . These data are important in planning anesthesia care for young @entity0 .

title: A prospective cohort study of emergence XXXX in the pediatric postanesthesia care unit.

answer: @entity2


abstract: We revealed that pre-treatment with @entity3 ( @entity6 ) 12 h before @entity2 (ADR) administration significantly reduced ADR-induced @entity1 compared with the simultaneous dosing schedule that was commonly used in previous studies. We considered that pre-treatment with @entity6 relieves ADR-induced @entity4 . In this study, we investigated the influence of @entity6 on the pharmacokinetics and pharmacodynamics of ADR in order to clarify the mechanism by which @entity6 pre-treatment relieves ADR-induced @entity4 . When ADR and/or @entity6 was intravenously administered, the @entity6 pre-treatment ( @entity6 -ADR) group showed significantly less @entity1 than the ADR-alone group. We examined hepatopathy, @entity0 , @entity5 , and @entity4 , all of which can cause @entity1 . Of these @entity1 , ADR-induced @entity4 was significantly relieved in the @entity6 -ADR group. To elucidate the mechanism by which @entity6 pre-treatment relieved ADR-induced @entity4 , lipid peroxidation as a proxy for the free radical level and the pharmacokinetics of ADR were measured. There was no difference in the pharmacokinetics of ADR between the ADR and @entity6 -ADR groups. On the other hand, the @entity6 -ADR group showed significantly inhibited lipid peroxidation in the heart compared with the ADR group. It was considered that @entity6 pre-administration inhibited ADR-induced free radicals and decreased @entity4 .

title: Mechanism of the cardioprotective effects of @entity3 pre-administration against @entity2 -induced XXXX .

answer: @entity4


abstract: We revealed that pre-treatment with @entity3 ( @entity6 ) 12 h before @entity2 (ADR) administration significantly reduced ADR-induced @entity1 compared with the simultaneous dosing schedule that was commonly used in previous studies. We considered that pre-treatment with @entity6 relieves ADR-induced @entity4 . In this study, we investigated the influence of @entity6 on the pharmacokinetics and pharmacodynamics of ADR in order to clarify the mechanism by which @entity6 pre-treatment relieves ADR-induced @entity4 . When ADR and/or @entity6 was intravenously administered, the @entity6 pre-treatment ( @entity6 -ADR) group showed significantly less @entity1 than the ADR-alone group. We examined hepatopathy, @entity0 , @entity5 , and @entity4 , all of which can cause @entity1 . Of these @entity1 , ADR-induced @entity4 was significantly relieved in the @entity6 -ADR group. To elucidate the mechanism by which @entity6 pre-treatment relieved ADR-induced @entity4 , lipid peroxidation as a proxy for the free radical level and the pharmacokinetics of ADR were measured. There was no difference in the pharmacokinetics of ADR between the ADR and @entity6 -ADR groups. On the other hand, the @entity6 -ADR group showed significantly inhibited lipid peroxidation in the heart compared with the ADR group. It was considered that @entity6 pre-administration inhibited ADR-induced free radicals and decreased @entity4 .

title: Mechanism of the cardioprotective effects of @entity3 pre-administration against XXXX -induced @entity4 .

answer: @entity2


abstract: We revealed that pre-treatment with @entity3 ( @entity6 ) 12 h before @entity2 (ADR) administration significantly reduced ADR-induced @entity1 compared with the simultaneous dosing schedule that was commonly used in previous studies. We considered that pre-treatment with @entity6 relieves ADR-induced @entity4 . In this study, we investigated the influence of @entity6 on the pharmacokinetics and pharmacodynamics of ADR in order to clarify the mechanism by which @entity6 pre-treatment relieves ADR-induced @entity4 . When ADR and/or @entity6 was intravenously administered, the @entity6 pre-treatment ( @entity6 -ADR) group showed significantly less @entity1 than the ADR-alone group. We examined hepatopathy, @entity0 , @entity5 , and @entity4 , all of which can cause @entity1 . Of these @entity1 , ADR-induced @entity4 was significantly relieved in the @entity6 -ADR group. To elucidate the mechanism by which @entity6 pre-treatment relieved ADR-induced @entity4 , lipid peroxidation as a proxy for the free radical level and the pharmacokinetics of ADR were measured. There was no difference in the pharmacokinetics of ADR between the ADR and @entity6 -ADR groups. On the other hand, the @entity6 -ADR group showed significantly inhibited lipid peroxidation in the heart compared with the ADR group. It was considered that @entity6 pre-administration inhibited ADR-induced free radicals and decreased @entity4 .

title: Mechanism of the cardioprotective effects of XXXX pre-administration against @entity2 -induced @entity4 .

answer: @entity3


abstract: Limited data suggest that @entity7 reductase inhibitors (statins) may slow @entity3 in individuals with @entity6 . This study was conducted to determine whether @entity9 reduced rates of @entity3 in @entity0 with moderate @entity6 . This was a post hoc subgroup analysis of a randomized double-blind placebo controlled trial. Data were analyzed from the CARE study (a randomized trial of @entity9 versus placebo in 4159 @entity0 with previous @entity4 and total plasma @entity2 < 240 mg/dl). @entity0 with estimated @entity8 ( @entity8 ) < 60 ml/min per 1.73 m(2) body surface area at baseline were considered to have moderate @entity6 . Multivariate regression was used to calculate rates of decline in @entity8 for individuals receiving @entity9 and placebo, controlling for prospectively determined covariates that might influence rates of renal function loss. Change in renal function could be calculated in 3384 individuals, of whom 690 (20.4%) had @entity8 < 60 ml/min per 1.73 m(2) and were eligible for inclusion. Among all individuals with @entity8 < 60 ml/min per 1.73 m(2)), the @entity8 decline in the @entity9 group was not significantly different from that in the placebo group (0.1 ml/min per 1.73 m(2)/yr slower; 95% CI, -0.2 to 0.4; P = 0.49). However, there was a significant stepwise inverse relation between @entity8 before treatment and slowing of renal function loss with @entity9 use, with more benefit in those with lower @entity8 at baseline (P = 0.04). Rate of change in @entity8 in the @entity9 group was 0.6 ml/min per 1.73 m(2)/yr slower than placebo (95% CI, -0.1 to 1.2; P = 0.07) in those with @entity8 < 50 ml/min, and 2.5 ml/min per 1.73 m(2)/yr slower (95% CI, 1.4 to 3.6 slower; P = 0.0001) in those with @entity8 < 40 ml/min per 1.73 m(2)/yr. @entity9 also reduced rates of @entity1 to a greater extent in @entity0 with than without @entity5 at baseline (P = 0.006). It is concluded that @entity9 may @entity3 in individuals with moderate to severe @entity1 , especially those with @entity5 . These findings require confirmation by a large randomized trial conducted specifically in @entity0 with @entity6 .

title: Effect of @entity9 on @entity3 in @entity0 with moderate XXXX and cardiovascular disease.

answer: @entity6


abstract: Limited data suggest that @entity7 reductase inhibitors (statins) may slow @entity3 in individuals with @entity6 . This study was conducted to determine whether @entity9 reduced rates of @entity3 in @entity0 with moderate @entity6 . This was a post hoc subgroup analysis of a randomized double-blind placebo controlled trial. Data were analyzed from the CARE study (a randomized trial of @entity9 versus placebo in 4159 @entity0 with previous @entity4 and total plasma @entity2 < 240 mg/dl). @entity0 with estimated @entity8 ( @entity8 ) < 60 ml/min per 1.73 m(2) body surface area at baseline were considered to have moderate @entity6 . Multivariate regression was used to calculate rates of decline in @entity8 for individuals receiving @entity9 and placebo, controlling for prospectively determined covariates that might influence rates of renal function loss. Change in renal function could be calculated in 3384 individuals, of whom 690 (20.4%) had @entity8 < 60 ml/min per 1.73 m(2) and were eligible for inclusion. Among all individuals with @entity8 < 60 ml/min per 1.73 m(2)), the @entity8 decline in the @entity9 group was not significantly different from that in the placebo group (0.1 ml/min per 1.73 m(2)/yr slower; 95% CI, -0.2 to 0.4; P = 0.49). However, there was a significant stepwise inverse relation between @entity8 before treatment and slowing of renal function loss with @entity9 use, with more benefit in those with lower @entity8 at baseline (P = 0.04). Rate of change in @entity8 in the @entity9 group was 0.6 ml/min per 1.73 m(2)/yr slower than placebo (95% CI, -0.1 to 1.2; P = 0.07) in those with @entity8 < 50 ml/min, and 2.5 ml/min per 1.73 m(2)/yr slower (95% CI, 1.4 to 3.6 slower; P = 0.0001) in those with @entity8 < 40 ml/min per 1.73 m(2)/yr. @entity9 also reduced rates of @entity1 to a greater extent in @entity0 with than without @entity5 at baseline (P = 0.006). It is concluded that @entity9 may @entity3 in individuals with moderate to severe @entity1 , especially those with @entity5 . These findings require confirmation by a large randomized trial conducted specifically in @entity0 with @entity6 .

title: Effect of XXXX on @entity3 in @entity0 with moderate @entity6 and cardiovascular disease.

answer: @entity9


abstract: Limited data suggest that @entity7 reductase inhibitors (statins) may slow @entity3 in individuals with @entity6 . This study was conducted to determine whether @entity9 reduced rates of @entity3 in @entity0 with moderate @entity6 . This was a post hoc subgroup analysis of a randomized double-blind placebo controlled trial. Data were analyzed from the CARE study (a randomized trial of @entity9 versus placebo in 4159 @entity0 with previous @entity4 and total plasma @entity2 < 240 mg/dl). @entity0 with estimated @entity8 ( @entity8 ) < 60 ml/min per 1.73 m(2) body surface area at baseline were considered to have moderate @entity6 . Multivariate regression was used to calculate rates of decline in @entity8 for individuals receiving @entity9 and placebo, controlling for prospectively determined covariates that might influence rates of renal function loss. Change in renal function could be calculated in 3384 individuals, of whom 690 (20.4%) had @entity8 < 60 ml/min per 1.73 m(2) and were eligible for inclusion. Among all individuals with @entity8 < 60 ml/min per 1.73 m(2)), the @entity8 decline in the @entity9 group was not significantly different from that in the placebo group (0.1 ml/min per 1.73 m(2)/yr slower; 95% CI, -0.2 to 0.4; P = 0.49). However, there was a significant stepwise inverse relation between @entity8 before treatment and slowing of renal function loss with @entity9 use, with more benefit in those with lower @entity8 at baseline (P = 0.04). Rate of change in @entity8 in the @entity9 group was 0.6 ml/min per 1.73 m(2)/yr slower than placebo (95% CI, -0.1 to 1.2; P = 0.07) in those with @entity8 < 50 ml/min, and 2.5 ml/min per 1.73 m(2)/yr slower (95% CI, 1.4 to 3.6 slower; P = 0.0001) in those with @entity8 < 40 ml/min per 1.73 m(2)/yr. @entity9 also reduced rates of @entity1 to a greater extent in @entity0 with than without @entity5 at baseline (P = 0.006). It is concluded that @entity9 may @entity3 in individuals with moderate to severe @entity1 , especially those with @entity5 . These findings require confirmation by a large randomized trial conducted specifically in @entity0 with @entity6 .

title: Effect of @entity9 on XXXX in @entity0 with moderate @entity6 and cardiovascular disease.

answer: @entity3


abstract: Limited data suggest that @entity7 reductase inhibitors (statins) may slow @entity3 in individuals with @entity6 . This study was conducted to determine whether @entity9 reduced rates of @entity3 in @entity0 with moderate @entity6 . This was a post hoc subgroup analysis of a randomized double-blind placebo controlled trial. Data were analyzed from the CARE study (a randomized trial of @entity9 versus placebo in 4159 @entity0 with previous @entity4 and total plasma @entity2 < 240 mg/dl). @entity0 with estimated @entity8 ( @entity8 ) < 60 ml/min per 1.73 m(2) body surface area at baseline were considered to have moderate @entity6 . Multivariate regression was used to calculate rates of decline in @entity8 for individuals receiving @entity9 and placebo, controlling for prospectively determined covariates that might influence rates of renal function loss. Change in renal function could be calculated in 3384 individuals, of whom 690 (20.4%) had @entity8 < 60 ml/min per 1.73 m(2) and were eligible for inclusion. Among all individuals with @entity8 < 60 ml/min per 1.73 m(2)), the @entity8 decline in the @entity9 group was not significantly different from that in the placebo group (0.1 ml/min per 1.73 m(2)/yr slower; 95% CI, -0.2 to 0.4; P = 0.49). However, there was a significant stepwise inverse relation between @entity8 before treatment and slowing of renal function loss with @entity9 use, with more benefit in those with lower @entity8 at baseline (P = 0.04). Rate of change in @entity8 in the @entity9 group was 0.6 ml/min per 1.73 m(2)/yr slower than placebo (95% CI, -0.1 to 1.2; P = 0.07) in those with @entity8 < 50 ml/min, and 2.5 ml/min per 1.73 m(2)/yr slower (95% CI, 1.4 to 3.6 slower; P = 0.0001) in those with @entity8 < 40 ml/min per 1.73 m(2)/yr. @entity9 also reduced rates of @entity1 to a greater extent in @entity0 with than without @entity5 at baseline (P = 0.006). It is concluded that @entity9 may @entity3 in individuals with moderate to severe @entity1 , especially those with @entity5 . These findings require confirmation by a large randomized trial conducted specifically in @entity0 with @entity6 .

title: Effect of @entity9 on @entity3 in XXXX with moderate @entity6 and cardiovascular disease.

answer: @entity0


abstract: Cardiac involvement is an uncommon presentation of hydatid cyst disease, accounting for approximately 0.5-2% of all @entity9 cases, and mainly occurring as part of a @entity2 . Herein, we report on an isolated cardiac hydatid cyst in a 57-year-old @entity0 . She presented with a complaint of squeezing @entity3 of 10 month-history. On transthoracic echocardiography, a mass like appearance with heterogeneous echogenicity was noted in the left ventricular wall, suggesting a primary @entity7 or a mass compressing the left ventricle. @entity5 computed tomography findings were reported as a calcified @entity4 50x65 mm in size and minimal pericardial fluid. Coronary angiography showed normal epicardial coronary arteries and an apical mass with calcified contours. Serological test was negative for @entity1 . Cardiac magnetic resonance imaging showed a @entity8 , 54x48 mm in size, in the left ventricular anterolateral wall, protruding into the lumen. After @entity6 treatment for four weeks, surgery was performed for excision of the cyst. During the operation, rupture of the cyst was noted. The diagnosis of cardiac hydatid cyst was confirmed by pathological examination. During a six-month follow-up, the @entity0 was asymptomatic, with no cystic appearance on transthoracic echocardiography.

title: Cardiac hydatid cyst mimicking XXXX and diagnosed by magnetic resonance imaging.

answer: @entity4


abstract: @entity4 ( @entity4 ) rarely affect @entity0 , mainly @entity0 . Pediatric @entity4 typically arise in the stomach as @entity2 with a multinodular growth pattern, epithelioid morphology, lymph node @entity1 , an absence of KIT and @entity5 gene mutations, and indolent behavior. Occasional @entity4 in adults show similar features. Such @entity2 are not widely recognized. @entity4 with a multinodular growth pattern in @entity0 over the age of 18 years were retrieved from surgical and consultation files. @entity6 and @entity7 -stained slides were reviewed, immunohistochemistry was performed, and KIT (exons 9, 11, 13, and 17) and @entity5 (exons 12, 14, and 18) genes were screened for mutations. Clinical follow-up was obtained. Sixteen cases were identified, affecting 13 @entity0 and 3 @entity0 (median age, 31.5 y; range, 19 to 56 y), all in the stomach. The mean @entity2 size was 5.4 cm (range, 1.8 to 11 cm); 4 were multifocal. All @entity2 showed a multinodular or plexiform architecture and epithelioid (N=3) or mixed epithelioid and spindle cell (N=13) morphology. Five @entity2 had vascular invasion; 6 had focal @entity3 . Mitotic activity ranged from 3 to 156/50 high-power fields (8 @entity2 had  <=5/50 high-power fields). Using Armed Forces Institute of Pathology risk stratification, categories for @entity2 were: none (N=2), very low risk (N=3), low risk (N=3), moderate risk (N=3), and high risk (N=5). By immunohistochemistry, all @entity2 were positive for KIT, 82% @entity10 , 72% @entity9 , 18% caldesmon, 9% S-100, 8% smooth muscle actin, and 0% desmin. All @entity2 were wild type for KIT and @entity5 in the exons that were screened. At primary resection, 9 @entity0 (56%) had lymph node @entity1 and 3 @entity0 had liver @entity1 . Follow-up ranged from 16 months to 16 years (median, 5 y). Two @entity2 recurred locally in the stomach and 7 @entity0 developed subsequent @entity1 to the lymph nodes (N=5), liver (N=3), and peritoneum/omentum (N=3). @entity2 from 7 @entity0 with @entity1 were Armed Forces Institute of Pathology low risk, very low risk, or no risk of recurrence. None of the @entity1 responded to treatment with @entity8 . One @entity0 died of disseminated liver and intra-abdominal @entity1 and the remaining @entity0 were alive at last follow-up. Gastric @entity4 in adults with a multinodular or plexiform growth pattern and epithelioid or mixed morphology are similar to pediatric @entity4 . Unlike conventional adult @entity4 , this distinctive subset predominantly affects @entity0 , often metastasizes to lymph nodes, and lacks mutations in KIT and @entity5 . Current risk assessment criteria do not reliably predict behavior for this group. Although @entity1 are common and most @entity2 are @entity8 resistant, they pursue a relatively indolent clinical course. Recognition of "pediatric-type" @entity4 in adults is critical for prognosis, appropriate therapy, and follow-up.

title: " XXXX in adults: distinctive histology predicts genotype and clinical behavior.

answer: @entity4


abstract: STUDY DESIGN: Retrospective analysis of @entity0 @entity1 with metastatic epidural @entity8 (MESCC) undergoing surgery and radiation therapy. OBJECTIVE: To assess feasibility and clinical outcome of multidisciplinary approach in @entity0 @entity1 with MESCC. SUMMARY OF BACKGROUND DATA: Studies so far published in the setting of surgery and/or radiotherapy in the management of MESCC usually included many @entity2 , without considering the different primary histology. However, when looking at prognostic variables of this therapy, histological type comes out as a major determinant of outcome. METHODS: Twenty-three @entity1 with symptomatic MESCC from @entity0 treated between January 2004 and April 2009 were included in this analysis. Twenty-six surgical procedures followed by radiotherapy were performed. Clinical outcome and local recurrence was evaluated by modified visual analog scale for @entity5 , Frankel scale for @entity3 , and magnetic resonance imaging or computed tomography scans. Twenty-three cases (88.4%) had @entity7 before treatment with a visual analog scale score 6 or greater; @entity3 (FS A-D) was present in 19 cases (65.5%). RESULTS: Complete remission of @entity5 , lasting until @entity6 or progression of disease in another skeletal site, was obtained in 25/26 cases (96.1%). All @entity1 had complete recovery of @entity3 . No major morbidity occurred. No @entity1 had recurrence in the site of treatment. Median survival was 36 months (range, 3-60) and overall survival at one, three, and five years was 70%, 42%, and 34%, respectively. CONCLUSION: We provided evidence of surgery and radiotherapy to be feasible with limited morbidity. Clinical outcome has been highly satisfactory in terms of @entity5 and @entity4 control. The discussion of each case within a multidisciplinary team is of central importance in defining the most appropriate therapeutic approach.

title: Surgery followed by radiotherapy for the treatment of metastatic epidural XXXX from @entity0 .

answer: @entity8


abstract: STUDY DESIGN: Retrospective analysis of @entity0 @entity1 with metastatic epidural @entity8 (MESCC) undergoing surgery and radiation therapy. OBJECTIVE: To assess feasibility and clinical outcome of multidisciplinary approach in @entity0 @entity1 with MESCC. SUMMARY OF BACKGROUND DATA: Studies so far published in the setting of surgery and/or radiotherapy in the management of MESCC usually included many @entity2 , without considering the different primary histology. However, when looking at prognostic variables of this therapy, histological type comes out as a major determinant of outcome. METHODS: Twenty-three @entity1 with symptomatic MESCC from @entity0 treated between January 2004 and April 2009 were included in this analysis. Twenty-six surgical procedures followed by radiotherapy were performed. Clinical outcome and local recurrence was evaluated by modified visual analog scale for @entity5 , Frankel scale for @entity3 , and magnetic resonance imaging or computed tomography scans. Twenty-three cases (88.4%) had @entity7 before treatment with a visual analog scale score 6 or greater; @entity3 (FS A-D) was present in 19 cases (65.5%). RESULTS: Complete remission of @entity5 , lasting until @entity6 or progression of disease in another skeletal site, was obtained in 25/26 cases (96.1%). All @entity1 had complete recovery of @entity3 . No major morbidity occurred. No @entity1 had recurrence in the site of treatment. Median survival was 36 months (range, 3-60) and overall survival at one, three, and five years was 70%, 42%, and 34%, respectively. CONCLUSION: We provided evidence of surgery and radiotherapy to be feasible with limited morbidity. Clinical outcome has been highly satisfactory in terms of @entity5 and @entity4 control. The discussion of each case within a multidisciplinary team is of central importance in defining the most appropriate therapeutic approach.

title: Surgery followed by radiotherapy for the treatment of metastatic epidural @entity8 from XXXX .

answer: @entity0


abstract: A case of acute idiopathic myopericarditis with transient severe @entity1 and akinesis of the interventricular septum on echocardiograms was reported. A 35-year-old @entity0 was admitted to our CCU because of @entity4 five days after the onset of "common cold". Electrocardiograms revealed low voltage and ST-segment elevation in all leads except for a VR and a VL. Serum @entity6 , GOT and LDH were slightly elevated. Echocardiograms showed severe @entity7 ( @entity7 , 20 mm), akinesis of the interventricular septum and moderate @entity5 . With improvement of the clinical course and of the hemodynamic data, the thickness and wall motion of the interventricular septum became normal. Serum antiviral antibodies were not elevated throughout the course. Transvenous percutaneous right ventricular endomyocardial biopsy revealed @entity3 with interstitial cellular infiltration and @entity1 in the subacute phase (8th hospital day), but showed only focal @entity2 in the chronic phase. Coronary arteriograms and left ventriculograms in the chronic phase (50th hospital day) were normal. From these findings we can conclude that the severe transient @entity7 is due to myocardial inflammatory @entity1 .

title: [Acute idiopathic myocarditis having myocardial inflammatory XXXX demonstrated by echocardiography: a case report].

answer: @entity1


abstract: BACKGROUND: MicroRNA-145 ( @entity4 ) has been reported to be a @entity1 -suppressing agent in several studies. It can repress pluripotency and control @entity0 embryonic stem cell differentiation by regulating the core pluripotency factor @entity5 . However, it is not known whether @entity4 can play a role in inducing @entity1 cell differentiation and repressing growth of @entity1 . METHODS: Ishikawa cells, the established @entity0 @entity3 cells, were treated with @entity4 mimics, inhibitor, or small interfering RNA @entity5 . @entity4 levels were assayed using TaqMan microRNA assays, and the messenger RNA levels of @entity5 and the differentiation marker glycodelin were measured using real-time polymerase chain reaction. The protein levels of @entity5 and glycodelin were characterized via flow cytometry, western blotting, and immunohistochemistry. In vivo activity was measured in a xenograft @entity2 model. RESULTS: Up-regulating @entity4 reduced the expression of @entity5 and induced the differentiation of Ishikawa cells to closely resemble normal endometrial epithelium both in vitro and in vivo. @entity4 successfully inhibited @entity1 growth. We also found that in @entity0 with @entity3 , @entity4 and @entity5 were expressed in tissues, and there was a relationship between @entity4 , @entity5 , and the degree of @entity1 cell differentiation. CONCLUSIONS: Our results strongly suggested that @entity4 is a @entity1 cell differentiation-inducing agent in @entity3 , and that @entity4 or @entity5 may be useful markers for grading @entity3 .

title: Up-regulation of microRNA-145 promotes differentiation by repressing XXXX in @entity0 @entity3 cells.

answer: @entity5