abstract: OBJECTIVES: To examine the safety and efficacy of anhydrous crystalline @entity3 for treatment of @entity2 and other symptoms of dryness in @entity0 with primary @entity1 . DESIGN: Anhydrous crystalline @entity3 was delivered orally as a 200-mg lozenge given three times daily over a 24-week period to a total of 100 subjects. All @entity0 had prominent complaints of persistent @entity2 associated with primary @entity1 . @entity0 were examined at baseline and every 6 weeks of treatment. SETTINGS: @entity0 were seen in outpatient clinics at a total of 27 sites within the United States. OUTCOME MEASURES: Unstimulated whole saliva output, a measure of basal salivary gland function, was determined at each visit. Symptoms associated with oral and ocular dryness were assessed at the same time with the use of 100-mm visual analogue scales. Safety was assessed by physical examination and laboratory studies. RESULTS: During this clinical trial, a majority of evaluable subjects (39/76) demonstrated an increase in unstimulated whole saliva output, and the treatment exhibited an excellent safety profile. The anhydrous crystalline @entity3 treatment led to significant improvement in several subjective measures of oral and ocular comfort. CONCLUSIONS: In this study, anhydrous crystalline @entity3 lozenges administered three times daily for 24 weeks improved salivary output and decreased complaints of @entity2 and eyes in @entity0 with primary @entity1 . Side-effects were minimal, and treatment was without significant adverse events. These results are similar to the benefits observed in two prior studies reported by the authors. This safe and simple intervention appears to provide clinical benefit to primary @entity1 @entity0 with distressing @entity2 .

title: A third study on the use of orally administered anhydrous crystalline @entity3 for relief of XXXX in primary @entity1 .

answer: @entity2


abstract: OBJECTIVE: Holter monitoring is one option in risk-stratification after acute @entity2 ( @entity2 ). Measurements of heart rate variability (HRV), @entity3 ( @entity3 ) and ST-segment elevation (ST upward arrow ) have been useful in predicting clinical outcome. We investigated if a combination of different Holter variables could optimize risk-stratification. DESIGN: One hundred and twenty-one @entity0 < 70 years old with a first @entity2 were studied. Holter monitoring for 24 h was started 11 +/- 5 days after @entity2 and analysed for HRV, @entity3 and ST. Follow-up was 10-12 years with @entity1 as endpoint. RESULTS: Thirty-six @entity0 were positive for > or = 1 Holter variable (HRV in 15, @entity3 in 16, ST in 10). At follow-up 22 @entity1 had occurred. The prognostic sensitivity of individual Holter variables ranged from 23 to 36%, but increased to 64% if combined. The @entity1 rate in Holter positive @entity0 (39%) was significantly higher than in Holter negative @entity0 (9%) (p < 0.0001). CONCLUSION: By combining measurements of HRV, @entity3 and ST the prognostic importance of Holter monitoring can be significantly improved. The @entity0 can be stratified in a low-risk group with an annual mortality < 1% vs a high-risk group with a @entity1 rate around 40% over the following decade.

title: Improvement of risk-stratification by use of a new combination of Holter variables in survivors of XXXX .

answer: @entity2


abstract: OBJECTIVE: An increase in intracranial pressure has been shown to threaten the outcome of @entity0 with @entity1 or traumatic @entity4 . Its impact on the outcome of @entity5 undergoing hypothermic @entity3 has been evaluated in this study. DESIGN: Fifty-six @entity5 underwent a 75-min period of hypothermic @entity3 at 20 degrees C. Intracranial pressure, cerebral microdialysis, hemodynamic and metabolic parameters were monitored throughout the experiment. The animals were allowed to survive until the 7th postoperative day and, then, electively killed. RESULTS: The 7-day survival rate was 60.7%, and among survivors, 20 of them (58.8%) developed @entity6 . A significant increase in intracranial pressure as compared with the baseline level was observed since the end of cooling (p = 0.047) and the difference became larger during all the postoperative intervals (p < 0.0001). Animals that died postoperatively tended to have higher intracranial pressure levels during all the postoperative intervals, but such a difference reached significance only at the 4-h postoperative interval (p = 0.040). The same tendency was observed among animals that survived until the 7th postoperative day and that developed @entity6 or not, but the difference between these two groups did not reach statistical significance. The animals that died or developed postoperatively @entity6 had higher intracranial pressure values postoperatively as compared with those that survived without developing @entity6 and such a difference reached significance at the 2-h (p = 0.015) and 4-h postoperative intervals (p = 0.035). The peak intracranial pressure was 17.2 mmHg (IQR, 13.7-20.8) in animals that died or developed @entity6 and 14.1 mmHg (IQR, 11.8-16.4) in those that survived 7 days without developing @entity6 (p = NS). CONCLUSION: Intracranial pressure increases significantly after 75 min of experimental hypothermic @entity3 and such an increase is associated with a high risk of @entity2 and @entity6 .

title: Increase of intracranial pressure after hypothermic XXXX in a chronic porcine model.

answer: @entity3


abstract: BACKGROUND: Aortobifemoral bypass grafting is the treatment of choice for @entity0 with symptomatic @entity2 . Yet, traditional operative exposure through a midline laparotomy incision carries significant morbidity. The authors compare operative and @entity0 outcomes following @entity4 ( @entity4 ) bypass and @entity3 ( @entity3 ) bypass. METHODS: An initial series of @entity0 who underwent @entity4 bypass grafting (n = 8) were compared with a simultaneous cohort of @entity0 treated with standard open bypass (n = 10). The two groups were similar with respect to age, weight, and sex. Operative parameters, clinical outcomes, and complications were compared. RESULTS: @entity4 was successfully performed in all eight cases attempted. Operative times did not differ between the laparoscopic and open groups (234 +/- 42 minutes vs. 206 +/- 43 minutes, P =.99). Mean @entity1 values were comparable (562 mL [ @entity4 ] vs. 756 mL [ @entity3 ], P =.56). There were no conversions. Time to resumption of oral intake (1.8 vs. 4.7 days, P =.001) and length of stay (3.8 vs. 6.3 days, P =.0004) were significantly shorter in the laparoscopic than in the open group. CONCLUSIONS: @entity4 is a safe and technically feasible procedure. When compared with the traditional open operation, this technique may result in shorter hospitalization, more rapid return of bowel function, and earlier return to activity.

title: Hand-assisted laparoscopic aortobifemoral bypass versus open bypass for XXXX .

answer: @entity2


abstract: PURPOSE: Recurrent or persistent @entity3 and @entity1 are typical complications of @entity4 . Toxic eosinophil granule proteins such as major basic protein ( @entity2 ) and @entity5 ( @entity5 ) may be involved in this pathogenetic process. This study was designed to demonstrate the presence of toxic eosinophil granule proteins in corneal tissue from a @entity0 with corneal complications of @entity4 . DESIGN: Observational case report. METHODS: Three corneal buttons of a @entity0 with @entity4 associated @entity1 or scarring were examined by light microscopy and by immunofluorescence technique. RESULTS: A linear deposition of eosinophil granular substance was detected subepithelially above Bowman's membrane in all corneal buttons. Indirect immunofluorescence identified this material as @entity2 and @entity5 . The deposits were not limited to the area of ulceration, but were also found underneath intact corneal epithelium. Multiple eosinophils were present in the upper @entity3 . Normal corneas and negative control sections of the pathologic buttons revealed only minimal nonspecific staining at the surface of the epithelium. CONCLUSIONS: Both @entity2 and @entity5 are known to affect @entity0 corneal epithelial cell viability and morphology in vitro. Moreover, @entity2 was shown to inhibit epithelial migration and protein synthesis. These toxic eosinophil proteins may also be responsible for corneal instability, recurrent and persistent corneal epithelial defects and @entity1 in @entity0 with @entity4 .

title: Toxic eosinophil granule protein deposition in corneal XXXX and scars associated with @entity4 .

answer: @entity1


abstract: PURPOSE: Recurrent or persistent @entity3 and @entity1 are typical complications of @entity4 . Toxic eosinophil granule proteins such as major basic protein ( @entity2 ) and @entity5 ( @entity5 ) may be involved in this pathogenetic process. This study was designed to demonstrate the presence of toxic eosinophil granule proteins in corneal tissue from a @entity0 with corneal complications of @entity4 . DESIGN: Observational case report. METHODS: Three corneal buttons of a @entity0 with @entity4 associated @entity1 or scarring were examined by light microscopy and by immunofluorescence technique. RESULTS: A linear deposition of eosinophil granular substance was detected subepithelially above Bowman's membrane in all corneal buttons. Indirect immunofluorescence identified this material as @entity2 and @entity5 . The deposits were not limited to the area of ulceration, but were also found underneath intact corneal epithelium. Multiple eosinophils were present in the upper @entity3 . Normal corneas and negative control sections of the pathologic buttons revealed only minimal nonspecific staining at the surface of the epithelium. CONCLUSIONS: Both @entity2 and @entity5 are known to affect @entity0 corneal epithelial cell viability and morphology in vitro. Moreover, @entity2 was shown to inhibit epithelial migration and protein synthesis. These toxic eosinophil proteins may also be responsible for corneal instability, recurrent and persistent corneal epithelial defects and @entity1 in @entity0 with @entity4 .

title: Toxic eosinophil granule protein deposition in corneal @entity1 and scars associated with XXXX .

answer: @entity4


abstract: @entity3 ( @entity3 ) risk factors affect a large proportion of European adult populations; hence most @entity3 results from the exposure of many @entity0 to moderately elevated risk factor levels. The population strategy is directed to improving the health-related behaviour of the entire population, by means of mass education and administrative measures aimed at nutrition, smoking and exercise; these measures are reviewed in some detail. This approach is inadequate for minimising risk in the minority in whom pronounced risk factor levels are present (e.g. major forms of hyperlipidaemia); such @entity0 require individual therapy in a clinical setting, i.e. an individual strategy. The @entity5 Society (EAS) endorses both strategies and regards them as complementary. It advocates a case-finding approach to identifying those @entity0 requiring individual care. Although lipid risk factors, like blood pressure, are continuous variables, the EAS has defined action limits for plasma @entity2 , @entity4 and HDL- @entity2 concentrations; the interpretation of these is influenced by the presence and extent of other risk factors and of @entity1 , and by age and sex. Recently the EAS has produced guidelines on the recognition and treatment of hyperlipidaemia. These provide sufficient step by step detail to permit the effective, safe management of most hyperlipidaemic @entity0 by the non-specialised physician, with advice on dietary and drug therapies, and the investigation and management of all major forms of hyperlipidaemia. The main features of these guidelines are described in this paper.

title: Population and individual strategies for the prevention of XXXX . Policy of the @entity5 Society.

answer: @entity3


abstract: @entity3 ( @entity3 ) risk factors affect a large proportion of European adult populations; hence most @entity3 results from the exposure of many @entity0 to moderately elevated risk factor levels. The population strategy is directed to improving the health-related behaviour of the entire population, by means of mass education and administrative measures aimed at nutrition, smoking and exercise; these measures are reviewed in some detail. This approach is inadequate for minimising risk in the minority in whom pronounced risk factor levels are present (e.g. major forms of hyperlipidaemia); such @entity0 require individual therapy in a clinical setting, i.e. an individual strategy. The @entity5 Society (EAS) endorses both strategies and regards them as complementary. It advocates a case-finding approach to identifying those @entity0 requiring individual care. Although lipid risk factors, like blood pressure, are continuous variables, the EAS has defined action limits for plasma @entity2 , @entity4 and HDL- @entity2 concentrations; the interpretation of these is influenced by the presence and extent of other risk factors and of @entity1 , and by age and sex. Recently the EAS has produced guidelines on the recognition and treatment of hyperlipidaemia. These provide sufficient step by step detail to permit the effective, safe management of most hyperlipidaemic @entity0 by the non-specialised physician, with advice on dietary and drug therapies, and the investigation and management of all major forms of hyperlipidaemia. The main features of these guidelines are described in this paper.

title: Population and individual strategies for the prevention of @entity3 . Policy of the XXXX Society.

answer: @entity5


abstract: Experimental studies indicate significant cardioprotective effects of recombinant @entity5 ( @entity5 ) by binding to the @entity6 ( @entity6 ) and by inducing various molecular mechanisms, including activation of @entity3 , a transcription factor that induces anti-apoptotic genes. However, specific molecular mechanisms of @entity6 regulation in cardiomyocytes are unknown. We identified a 774 bp regulatory domain in the @entity6 5' flanking region by reporter gene assays in @entity0 HL-1 cardiomyocytes. The binding sites for @entity8 and Sp transcription factors both significantly contributed to @entity6 promoter activity. DNA-binding studies (EMSA and ChIP assays) identified @entity3 and @entity4 as @entity6 promoter-binding proteins in @entity7 cardiomyocytes. Although @entity4 alone stimulates @entity6 only slightly, forced expression of @entity3 significantly induced @entity6 mRNA expression. In addition, knockdown of @entity3 (but also of @entity4 ) resulted in a significant decrease of @entity6 transcript levels in HL-1 cardiomyocytes. Cumulative in vitro data suggest that function of the @entity4 site is essential for the @entity3 -mediated transcription. In vivo, analysis of @entity0 expressing an inducible small-hairpin RNA against @entity3 confirmed suppression of @entity6 expression in the heart. Treating @entity0 with high-dose @entity2 not only resulted in @entity3 protein depletion, but also down-regulated @entity6 , followed by up-regulation of @entity6 transcripts when @entity3 levels recovered. In conclusion, we identified @entity3 as novel regulator of @entity6 transcription in cardiomyocytes. In models of @entity1 , down-regulation of @entity3 or @entity4 may limit the accessibility of the @entity6 for binding of erythropoiesis-stimulating agents (ESA). Thereby our data underline the essential role of @entity3 in mediating cardioprotective effects.

title: XXXX and @entity4 regulate expression of the @entity5 receptor in cardiomyocytes.

answer: @entity3


abstract: Experimental studies indicate significant cardioprotective effects of recombinant @entity5 ( @entity5 ) by binding to the @entity6 ( @entity6 ) and by inducing various molecular mechanisms, including activation of @entity3 , a transcription factor that induces anti-apoptotic genes. However, specific molecular mechanisms of @entity6 regulation in cardiomyocytes are unknown. We identified a 774 bp regulatory domain in the @entity6 5' flanking region by reporter gene assays in @entity0 HL-1 cardiomyocytes. The binding sites for @entity8 and Sp transcription factors both significantly contributed to @entity6 promoter activity. DNA-binding studies (EMSA and ChIP assays) identified @entity3 and @entity4 as @entity6 promoter-binding proteins in @entity7 cardiomyocytes. Although @entity4 alone stimulates @entity6 only slightly, forced expression of @entity3 significantly induced @entity6 mRNA expression. In addition, knockdown of @entity3 (but also of @entity4 ) resulted in a significant decrease of @entity6 transcript levels in HL-1 cardiomyocytes. Cumulative in vitro data suggest that function of the @entity4 site is essential for the @entity3 -mediated transcription. In vivo, analysis of @entity0 expressing an inducible small-hairpin RNA against @entity3 confirmed suppression of @entity6 expression in the heart. Treating @entity0 with high-dose @entity2 not only resulted in @entity3 protein depletion, but also down-regulated @entity6 , followed by up-regulation of @entity6 transcripts when @entity3 levels recovered. In conclusion, we identified @entity3 as novel regulator of @entity6 transcription in cardiomyocytes. In models of @entity1 , down-regulation of @entity3 or @entity4 may limit the accessibility of the @entity6 for binding of erythropoiesis-stimulating agents (ESA). Thereby our data underline the essential role of @entity3 in mediating cardioprotective effects.

title: @entity3 and @entity4 regulate expression of the XXXX receptor in cardiomyocytes.

answer: @entity5


abstract: Experimental studies indicate significant cardioprotective effects of recombinant @entity5 ( @entity5 ) by binding to the @entity6 ( @entity6 ) and by inducing various molecular mechanisms, including activation of @entity3 , a transcription factor that induces anti-apoptotic genes. However, specific molecular mechanisms of @entity6 regulation in cardiomyocytes are unknown. We identified a 774 bp regulatory domain in the @entity6 5' flanking region by reporter gene assays in @entity0 HL-1 cardiomyocytes. The binding sites for @entity8 and Sp transcription factors both significantly contributed to @entity6 promoter activity. DNA-binding studies (EMSA and ChIP assays) identified @entity3 and @entity4 as @entity6 promoter-binding proteins in @entity7 cardiomyocytes. Although @entity4 alone stimulates @entity6 only slightly, forced expression of @entity3 significantly induced @entity6 mRNA expression. In addition, knockdown of @entity3 (but also of @entity4 ) resulted in a significant decrease of @entity6 transcript levels in HL-1 cardiomyocytes. Cumulative in vitro data suggest that function of the @entity4 site is essential for the @entity3 -mediated transcription. In vivo, analysis of @entity0 expressing an inducible small-hairpin RNA against @entity3 confirmed suppression of @entity6 expression in the heart. Treating @entity0 with high-dose @entity2 not only resulted in @entity3 protein depletion, but also down-regulated @entity6 , followed by up-regulation of @entity6 transcripts when @entity3 levels recovered. In conclusion, we identified @entity3 as novel regulator of @entity6 transcription in cardiomyocytes. In models of @entity1 , down-regulation of @entity3 or @entity4 may limit the accessibility of the @entity6 for binding of erythropoiesis-stimulating agents (ESA). Thereby our data underline the essential role of @entity3 in mediating cardioprotective effects.

title: @entity3 and XXXX regulate expression of the @entity5 receptor in cardiomyocytes.

answer: @entity4


abstract: Recent data indicate that phagocytosis mediated by FcgammaRs is controlled by the @entity1 and @entity2 families of protein @entity0 kinases. In this study, we demonstrate a sequential involvement of @entity3 and @entity2 in the phagocytosis of IgG-coated particles. The particles isolated at the stage of their binding to FcgammaRs (4 degrees C) were accompanied by high amounts of @entity3 , in addition to the signaling gamma-chain of FcgammaRs. Simultaneously, the particle binding induced rapid @entity0 phosphorylation of numerous proteins. During synchronized internalization of the particles induced by shifting the cell to 37 degrees C, @entity2 kinase and @entity1 homology 2-containing @entity0 phosphatase-1 ( @entity4 ) were associated with the formed phagosomes. At this step, most of the proteins were dephosphorylated, although some underwent further @entity0 phosphorylation. Quantitative immunoelectron microscopy studies confirmed that @entity3 accumulated under the plasma membrane beneath the bound particles. High amounts of the gamma-chain and @entity0 -phosphorylated proteins were also observed under the bound particles. When the particles were internalized, the gamma-chain was still detected in the region of the phagosomes, while amounts of @entity3 were markedly reduced. In contrast, the vicinity of the phagosomes was heavily decorated with anti- @entity2 and anti- @entity4 Abs. The local level of protein @entity0 phosphorylation was reduced. The data indicate that the accumulation of @entity3 during the binding of IgG-coated particles to FcgammaRs correlated with strong @entity0 phosphorylation of numerous proteins, suggesting an initiating role for @entity3 in protein phosphorylation at the onset of the phagocytosis. @entity2 kinase and @entity4 phosphatase are mainly engaged at the stage of particle internalization.

title: @entity3 and XXXX kinases are sequentially engaged in phagocytosis mediated by Fc gamma R.

answer: @entity2


abstract: Recent data indicate that phagocytosis mediated by FcgammaRs is controlled by the @entity1 and @entity2 families of protein @entity0 kinases. In this study, we demonstrate a sequential involvement of @entity3 and @entity2 in the phagocytosis of IgG-coated particles. The particles isolated at the stage of their binding to FcgammaRs (4 degrees C) were accompanied by high amounts of @entity3 , in addition to the signaling gamma-chain of FcgammaRs. Simultaneously, the particle binding induced rapid @entity0 phosphorylation of numerous proteins. During synchronized internalization of the particles induced by shifting the cell to 37 degrees C, @entity2 kinase and @entity1 homology 2-containing @entity0 phosphatase-1 ( @entity4 ) were associated with the formed phagosomes. At this step, most of the proteins were dephosphorylated, although some underwent further @entity0 phosphorylation. Quantitative immunoelectron microscopy studies confirmed that @entity3 accumulated under the plasma membrane beneath the bound particles. High amounts of the gamma-chain and @entity0 -phosphorylated proteins were also observed under the bound particles. When the particles were internalized, the gamma-chain was still detected in the region of the phagosomes, while amounts of @entity3 were markedly reduced. In contrast, the vicinity of the phagosomes was heavily decorated with anti- @entity2 and anti- @entity4 Abs. The local level of protein @entity0 phosphorylation was reduced. The data indicate that the accumulation of @entity3 during the binding of IgG-coated particles to FcgammaRs correlated with strong @entity0 phosphorylation of numerous proteins, suggesting an initiating role for @entity3 in protein phosphorylation at the onset of the phagocytosis. @entity2 kinase and @entity4 phosphatase are mainly engaged at the stage of particle internalization.

title: XXXX and @entity2 kinases are sequentially engaged in phagocytosis mediated by Fc gamma R.

answer: @entity3


abstract: The purpose of this study was to assess stability of @entity1 across time. 29 @entity0 were seen at both 9 and 9.5 mo.; 20 of these @entity0 were seen again at 12 mo. At each visit the @entity0 were presented several objects for familiarization and tested for response to discrepant objects. Each trial was scored for the duration of looking, rotating the object, fingering, mouthing, and banging, the frequency of transferring the object from hand to hand, and the frequency of dropping, throwing and pushing the object away. Analysis of the data yielded moderate to high correlations between 9 and 9.5 mo. for all but one behavior. Correlations between 9 and 12 mo. were in the same range for most of the behaviors. On the test trials, there were fewer significant correlations. When the behaviors were separated into exploratory and nonexploratory categories, there was more stability for the nonexploratory behaviors; summary scores for both were concurrently related to Bayley Mental Development Index at 12 mo., but in opposite directions. The results suggest that there is stability in some @entity1 , and further, that it is useful to conceptualize two types of @entity1 .

title: Stability of individual differences in XXXX ' manipulation and exploration of objects.

answer: @entity0


abstract: We report two cases of @entity9 in young @entity0 . The first @entity0 was 15 years old and had experienced @entity1 and @entity6 for one month, but no @entity5 . Cerebral tomodensitometry results were normal, but lumbar puncture showed increased pressure and normal biology. Benign intracranial @entity4 was diagnosed. Recent treatment with @entity8 for acne @entity13 was the only etiology. @entity9 was totally regressed at 6 weeks, after interruption of the antibiotic treatment. A prescription of @entity10 was added for a short period of 10 days. The second @entity0 , aged 29 years, presented @entity9 with severe @entity5 , with vision limited to light perception with @entity11 of the right eye. Lumbar puncture was not indicated because of a hypophyseal microadenoma revealed on MRI investigation. No other associated abnormalities were observed, in particular, no @entity3 . Corticotherapy using @entity7 for 72 hours had no clinical effect. Fast visual recovery was obtained with intravenous @entity10 therapy and was completely resolved at 2 months. Right @entity5 persisted. @entity8 and @entity2 are recognized as precipitating factors in @entity12 . The literature advocates consideration of surgical treatment by optic nerve sheath fenestration if antiedematous treatment has no effect and the eye is nearly blind.

title: [Bilateral XXXX in young @entity0 : two case reports of @entity12 ?].

answer: @entity9


abstract: We report two cases of @entity9 in young @entity0 . The first @entity0 was 15 years old and had experienced @entity1 and @entity6 for one month, but no @entity5 . Cerebral tomodensitometry results were normal, but lumbar puncture showed increased pressure and normal biology. Benign intracranial @entity4 was diagnosed. Recent treatment with @entity8 for acne @entity13 was the only etiology. @entity9 was totally regressed at 6 weeks, after interruption of the antibiotic treatment. A prescription of @entity10 was added for a short period of 10 days. The second @entity0 , aged 29 years, presented @entity9 with severe @entity5 , with vision limited to light perception with @entity11 of the right eye. Lumbar puncture was not indicated because of a hypophyseal microadenoma revealed on MRI investigation. No other associated abnormalities were observed, in particular, no @entity3 . Corticotherapy using @entity7 for 72 hours had no clinical effect. Fast visual recovery was obtained with intravenous @entity10 therapy and was completely resolved at 2 months. Right @entity5 persisted. @entity8 and @entity2 are recognized as precipitating factors in @entity12 . The literature advocates consideration of surgical treatment by optic nerve sheath fenestration if antiedematous treatment has no effect and the eye is nearly blind.

title: [Bilateral @entity9 in young @entity0 : two case reports of XXXX ?].

answer: @entity12


abstract: We report two cases of @entity9 in young @entity0 . The first @entity0 was 15 years old and had experienced @entity1 and @entity6 for one month, but no @entity5 . Cerebral tomodensitometry results were normal, but lumbar puncture showed increased pressure and normal biology. Benign intracranial @entity4 was diagnosed. Recent treatment with @entity8 for acne @entity13 was the only etiology. @entity9 was totally regressed at 6 weeks, after interruption of the antibiotic treatment. A prescription of @entity10 was added for a short period of 10 days. The second @entity0 , aged 29 years, presented @entity9 with severe @entity5 , with vision limited to light perception with @entity11 of the right eye. Lumbar puncture was not indicated because of a hypophyseal microadenoma revealed on MRI investigation. No other associated abnormalities were observed, in particular, no @entity3 . Corticotherapy using @entity7 for 72 hours had no clinical effect. Fast visual recovery was obtained with intravenous @entity10 therapy and was completely resolved at 2 months. Right @entity5 persisted. @entity8 and @entity2 are recognized as precipitating factors in @entity12 . The literature advocates consideration of surgical treatment by optic nerve sheath fenestration if antiedematous treatment has no effect and the eye is nearly blind.

title: [Bilateral @entity9 in young XXXX : two case reports of @entity12 ?].

answer: @entity0


abstract: BACKGROUND: The authors report their initial experience with partial and total thyroidectomy, and neck exploration for @entity3 using the video-assisted approach. @entity0 AND METHODS: Between June 1999 and March 2001, 114 @entity0 underwent a thyroid (n = 57) or @entity4 (n = 57) operation using a video-assisted cervical approach. Video-assisted neck exploration was conducted in all cases under general anaesthesia leading to a partial or total thyroidectomy, and to a selective adenoma removal in PHPT or to a subtotal @entity4 resection in SHPT. RESULTS: IN THE THYROID GROUP: The mean cranio-caudal and transversal diameter of the resected specimen were respectively 4.9 +/- 0.9 and 2.8 +/- 0.6 cm, and mean total lobar weight was 11.7 +/- 5.8 g. Conversion to conventional surgery was required in 5 @entity0 (8.8%). The mean operative time was 133.9 +/- 26.9 and 86.5 +/- 22.5 minutes for total and partial thyroidectomy respectively. The laryngeal nerve was identified in 96% of cases. The mean length of skin incision was 24.0 +/- 2 mm. There were 3 cases of postoperative @entity5 , and 2 cases of postoperative hoarseness. The postoperative hospital stay was less than 24 hours for 72.7% of @entity0 . The @entity1 intensity at day one (VAS) was 2.1 +/- 1.3. IN THE PARATHYROID GROUP: Seven of the 44 @entity0 who underwent PHPT (15.9%) and 4 of the 13 @entity0 who underwent surgery for SHPT (30.8%) were converted to a conventional surgical technique. The mean operative time in PHPT and SHPT was 47.3 +/- 22.3 minutes and 136.8 +/- 18.7 minutes, respectively. Recurrent laryngeal nerve was identified in 53.1% of the @entity0 . The median diameter and weight of the resected @entity4 glands were 1.5 cm (range 0.8-2.7) and 0.9 g (range 0.5-7), respectively. The length of skin incision was 24 +/- 2 mm. All but 2 @entity0 are currently cured. Postoperative complications included @entity2 and transient hoarseness each in one @entity0 (1.75%). The median @entity1 intensity at day one (VAS) was 0.5 (range: 0 to 3.6). In the PHPT group, the postoperative hospital stay was less than 24 hours for 56.7% of the @entity0 , and less than 48 hours for 91.9% of them. CONCLUSION: The video-assisted approach for thyroid and @entity4 surgery is feasible, safe and effective in selected cases. Benefits for the @entity0 should be further assessed in future prospective comparative trials.

title: Contributions of the video-assisted approach to thyroid and XXXX surgery.

answer: @entity4


abstract: 1. The effects of @entity1 ( @entity2 ) on developed @entity3 and intracellular @entity0 concentration (as measured with aequorin) were studied in ferret papillary muscles, and on twitch shortening, the action potential and membrane currents in ferret ventricular myocytes. 2. Addition of @entity2 to ferret papillary muscles resulted in decreases in developed @entity3 and the intracellular @entity0 transient, both of which then partially recovered in the continued presence of @entity2 ('fade' of the response). On wash-off of @entity2 both developed @entity3 and the intracellular @entity0 transient increased above control ('rebound') before returning to control values. 3. Addition of @entity2 to ferret ventricular myocytes resulted in a membrane hyperpolarization of 2 +/- 0.5 mV (mean +/- S.E.M.; n = 9), a decrease in action potential duration to 23 +/- 6% of control and a decrease in twitch shortening to 31 +/- 5% of control. In the continued presence of @entity2 these responses to @entity2 faded. Thirty seconds after the maximal effect of @entity2 , action potential duration had partially recovered to 34 +/- 6% of control and twitch shortening to 46 +/- 7% of control. 4. The effects of @entity2 on twitch shortening could be mimicked under voltage clamp by varying voltage clamp pulse duration to simulate the @entity2 -induced changes in action potential duration. 5. When @entity2 was applied during a train of voltage clamp pulses of constant duration, 81% of the cells showed less than a 20% decrease in @entity0 current and twitch shortening. However in 19% of the cells twitch shortening and the apparent @entity0 current decreased by more than 30%. 6. In the 81% of cells, the normal decrease in twitch shortening was wholly the result of the shortening of the action potential. This in turn was the result of an increase in an outward background current which increased the rate of repolarization during the action potential. The @entity2 -induced background current reversed at -89 +/- 2 mV and showed inward-going rectification; these properties suggest that it was carried by K+. 7. In the 19% of cells, the normal decrease in twitch shortening was only partly the result of the shortening of the action potential (due to both the increase in outward background current as well as the apparent decrease in @entity0 current). In these cells the decrease in twitch shortening may also have been partly the direct result of the apparent decrease of @entity0 current.

title: The negative inotropic effect of XXXX on ferret ventricular myocardium.

answer: @entity1


abstract: It has been suggested that @entity2 @entity0 suffer a selective loss of episodic memory while semantic memory remains well preserved. To assess the validity of this idea we studied remote memory in an @entity2 @entity0 , (M.R.L.), using several different measures that differ in the extent to which they engage episodic or semantic memory. On two different versions of the Albert et al. (1979) remote memory battery M.R.L. displayed severe @entity3 ( @entity3 ) extending backwards in time for about 15 years with excellent preservation of older memories. With standard recall instructions his overall performance on the Crovitz test of autobiographical memory was impaired and all of M.R.L.'s specific, temporally dated memories were given from the first half of his life. When asked to reconstruct his past residential history in detail, M.R.L. provide specific and generally accurate information for residences occupied from his boyhood until 1970, but thereafter his memory became quite unreliable. On a test of knowledge of terms commonly employed in the surveying profession, in which he worked for the past 20 years, M.R.L.'s performance was also impaired. The consistent pattern of @entity3 displayed by this @entity0 on all of the tests of remote memory indicates that both @entity1 are impaired in @entity2 .

title: Remote memory in a @entity0 with XXXX due to hypoxia.

answer: @entity2


abstract: It has been suggested that @entity2 @entity0 suffer a selective loss of episodic memory while semantic memory remains well preserved. To assess the validity of this idea we studied remote memory in an @entity2 @entity0 , (M.R.L.), using several different measures that differ in the extent to which they engage episodic or semantic memory. On two different versions of the Albert et al. (1979) remote memory battery M.R.L. displayed severe @entity3 ( @entity3 ) extending backwards in time for about 15 years with excellent preservation of older memories. With standard recall instructions his overall performance on the Crovitz test of autobiographical memory was impaired and all of M.R.L.'s specific, temporally dated memories were given from the first half of his life. When asked to reconstruct his past residential history in detail, M.R.L. provide specific and generally accurate information for residences occupied from his boyhood until 1970, but thereafter his memory became quite unreliable. On a test of knowledge of terms commonly employed in the surveying profession, in which he worked for the past 20 years, M.R.L.'s performance was also impaired. The consistent pattern of @entity3 displayed by this @entity0 on all of the tests of remote memory indicates that both @entity1 are impaired in @entity2 .

title: Remote memory in a XXXX with @entity2 due to hypoxia.

answer: @entity0


abstract: Extracts of 13 Brazilian medicinal plants were screened for their antimicrobial activity against bacteria and @entity1 . Of these, 10 plant extracts showed varied levels of antibacterial activity. Piper regnellii presented a good activity against @entity3 and @entity6 , a moderate activity on @entity4 , and a weak activity against @entity2 . Punica granatum showed good activity on @entity3 and was inactive against the other standard strains. Eugenia uniflora presented moderate activity on both @entity3 and @entity2 . Psidium guajava,Tanacetum vulgare, Arctium lappa, Mikania glomerata, Sambucus canadensis, Plantago major and Erythrina speciosa presented some degree of antibacterial activity. Spilanthes acmella, @entity8 were considered inactive. Five of the plant extracts presented compounds with Rf values similar to the antibacterial compounds visible on bioautogram. Of these, three plants belong to the Asteraceae family. This may mean that the same compounds are responsible for the antibacterial activity in these plants. Anticandidal activity was detected in nine plant extracts (P. guajava, E. uniflora, P. granatum, A. lappa, @entity5 , M. glomerata, L. alba, P. regnellii, and @entity7 ). The results might explain the ethnobotanical use of the studied species for the treatment of various @entity0 .

title: Screening of some plants used in the Brazilian folk medicine for the treatment of XXXX .

answer: @entity0


abstract: BACKGROUND AND STUDY AIMS: Management options for @entity2 ( @entity1 ) include @entity1 removal or surveillance. If the latter is chosen, it requires repeated measurements of the @entity1 diameter. Although this can be achieved using endoscopy or endosonography (EUS), a less invasive and cheaper method would be welcome. The aim of this prospective study was to assess the proportion of gastric @entity1 that can be visualized using transabdominal ultrasound of the water-filled stomach. @entity0 AND METHODS: Fifty-one consecutive @entity0 with endosonographically diagnosed gastric @entity1 underwent transabdominal ultrasound examinations of the water-filled stomach performed immediately after EUS; both procedures were carried out by the same investigator. Transabdominal ultrasound was considered positive only if: firstly, the @entity1 was visualized unequivocally; secondly, its dimensions could be measured; and thirdly, photographic documentation could be recorded. In each case, a positive result had to be confirmed by an independent investigator, who reviewed the photographic documentation. RESULTS: The median size of @entity1 on EUS was 25 mm (range 4 - 55 mm). Twelve @entity1 were located in the antrum, 25 in the gastric body, and 14 in the gastric fundus or @entity3 . Transabdominal ultrasound demonstrated the @entity1 in 35 of 51 @entity0 (69 %). For @entity1 < or = 30 mm, the visualization rate was 61 % (22 of 36). The location of the @entity1 and its EUS features did not significantly affect the sensitivity of transabdominal ultrasound. CONCLUSIONS: In 69 % of @entity0 with endosonographically diagnosed gastric @entity1 , the @entity1 can also be visualized (and measured) using transabdominal ultrasound of the water-filled stomach. This noninvasive and inexpensive method may potentially be useful for surveillance in @entity0 with @entity1 , and further evaluation in this setting is warranted.

title: Transabdominal ultrasound for visualizing XXXX diagnosed by endosonography: can surveillance be simplified?

answer: @entity2


abstract: 1. The current-voltage relationships of @entity2 of @entity0 have been determined using constant current and voltage clamp techniques. 2. The current-voltage relationships were non-linear over the membrane potential range -60 to -90 mV, the conductance increasing with hyperpolarization. 3. The membrane potential ranges over which the membrane conductance increased were changed by changing the external concentration of @entity1 ions. 4. Changing the external concentrations of @entity3 and @entity4 ions had no effect on the arteriolar current-voltage relationships. 5. The hyperpolarization-activated conductance increase was prevented by low concentrations of @entity5 ions. 6. It is suggested that these arterioles display @entity1 -selective inward rectification and that the rectifier supplies the dominant resting @entity1 conductance. The properties of this rectifier are compared with those of other tissues.

title: Inward rectification in submucosal arterioles of XXXX ileum.

answer: @entity0


abstract: There were 2385 (1236 female, 1149 male) cases of @entity3 diagnosed in Kaunas region. Forty-five cases of histologically confirmed malignant @entity5 diagnosed throughout 1981-2000 period are discussed. The disease was diagnosed to 37 @entity0 only after surgery and to other eight by means of endoscopical investigation. Before establishing the correct diagnosis, @entity2 was supposed to 27 @entity0 , gastric @entity4 to 12 @entity0 , gastropathia erosiva to 6 @entity0 . Histologically primary non-Hodgkin @entity5 was diagnosed to 29 @entity0 . That consisted 78.3 per cent of all surgically treated @entity0 , 64.4 per cent of histologically confirmed cases and 1.2 per cent of all diagnosed @entity3 . @entity2 was diagnosed to 16 @entity0 . Primary lymphogranulomatosis three cases. After supposed @entity1 , three @entity0 were operated. All @entity0 were examined by X-ray, CT and endoscopy. Biopsy was taken from pathological or not pathological mucous membrane.

title: [Diagnosis of XXXX ].

answer: @entity3


abstract: The objective of the study was to describe the practice patterns of the @entity2 ( @entity2 ) as compared with consensus guidelines for diagnosis and to determine whether practice patterns correlate with @entity0 demographics and physician specialty. A retrospective medical chart review was conducted at the American University Hospital, in Beirut, Lebanon. All adult and pediatric @entity0 admitted to the hospital between 1 January and 31 December 1998 who underwent either anticardiolipin antibodies (aCL) or @entity3 ( @entity3 ) testing were included in the study. @entity2 was compared with: (a) the consensus guidelines for clinical diagnosis; (b) physician specialty; and (c) @entity0 demographics (age, gender, ethnicity, health insurance status). Eighty-seven @entity0 fulfilled at least one clinical criterion for @entity2 ; 92% were for work-up of @entity1 and 8% for pregnancy morbidities. Fifty-one percent underwent both aCL and @entity3 . Overall 38% (33) of @entity0 had an abnormal test result, however only 18% (6) underwent retesting, of whom only two satisfied a minimum of 6 weeks between test and retest TheAPS diagnostic work-up was requested by 11 different specialties. Rheumatologists were the most consistent in asking for both tests. @entity2 is seen and diagnosed by a variety of medical specialties. Practice patterns as compared with the latest consensus are sub-optimal, and need to be improved. Interventions to help improve this have been discussed and are being implemented.

title: Practice patterns of XXXX at a tertiary teaching hospital in Lebanon.

answer: @entity2


abstract: Graves' @entity3 and @entity5 are closely related @entity2 . Whether the @entity5 is an integral part of @entity6 or a separate entity is controversial. To investigate this we have examined the genetic associations of @entity9 and @entity3 , and compared their phenotype and gene frequencies with a control normal population. @entity4 , and DR antigens were typed in 67 @entity0 with @entity5 ( @entity10 ), 60 @entity3 @entity0 without significant @entity5 ( @entity1 ) and 500 normal subjects. @entity0 were also typed for a variety of other genetic markers: blood group systems (10), serum proteins (6) and red cell enzyme systems (10). Increased frequency of B8 and @entity7 in @entity6 was confirmed; @entity8 occurred less frequently and appears to be protective. HLA antigen frequencies for @entity10 did not differ from @entity1 . The MNS blood group showed a significant association with @entity6 , the @entity1 @entity0 having a deficit of the s gene compared with controls. The most interesting finding was an increased frequency of blood group P in @entity10 @entity0 compared with either @entity1 or controls. Significant differences were not seen with any of the other HLA antigens, blood groups, protein or enzyme markers considered individually. Multivariate analysis applied first to the HLA and then to the non-HLA systems indicated clear separation of the two @entity0 groups. Although @entity5 shares the same HLA associations as @entity3 , it differs in the increased frequency of P blood group, suggesting that additional genetic factors may determine which @entity0 with @entity6 develop @entity9 .

title: Differentiation of XXXX from Graves' @entity3 by analysis of genetic markers.

answer: @entity2


abstract: Graves' @entity3 and @entity5 are closely related @entity2 . Whether the @entity5 is an integral part of @entity6 or a separate entity is controversial. To investigate this we have examined the genetic associations of @entity9 and @entity3 , and compared their phenotype and gene frequencies with a control normal population. @entity4 , and DR antigens were typed in 67 @entity0 with @entity5 ( @entity10 ), 60 @entity3 @entity0 without significant @entity5 ( @entity1 ) and 500 normal subjects. @entity0 were also typed for a variety of other genetic markers: blood group systems (10), serum proteins (6) and red cell enzyme systems (10). Increased frequency of B8 and @entity7 in @entity6 was confirmed; @entity8 occurred less frequently and appears to be protective. HLA antigen frequencies for @entity10 did not differ from @entity1 . The MNS blood group showed a significant association with @entity6 , the @entity1 @entity0 having a deficit of the s gene compared with controls. The most interesting finding was an increased frequency of blood group P in @entity10 @entity0 compared with either @entity1 or controls. Significant differences were not seen with any of the other HLA antigens, blood groups, protein or enzyme markers considered individually. Multivariate analysis applied first to the HLA and then to the non-HLA systems indicated clear separation of the two @entity0 groups. Although @entity5 shares the same HLA associations as @entity3 , it differs in the increased frequency of P blood group, suggesting that additional genetic factors may determine which @entity0 with @entity6 develop @entity9 .

title: Differentiation of @entity2 from Graves' XXXX by analysis of genetic markers.

answer: @entity3


abstract: @entity3 of the calcaneus typically occur in individuals working on ladders, scaffolding or roofs. Male individuals in their productive age are most at risk. The functional problems that frequently persist are a well-known risk since they may obstruct a safe resumption of the former job. According to the data of the National Institute for Sickness and Invalidity Insurance the number of @entity1 in Belgium have stabilised over the last ten years. These figures indicate the necessity for a better prevention policy. Scientific literature about the problem of @entity2 in these cases is rare and lacks uniformity. A retrospective study was therefore performed on 65 private insurance compensation @entity0 who were treated for intra-articular @entity1 . The mean period of work incapacity was 260.5 days and the mean percentage of impairment was 12.3%. A large group (86.2%) were able to resume their former activities including the height workers. More than half of the @entity0 (57%) needed a supportive device. Working at heights and falls from a height were a significant risk factor for long-term work incapacity. The figures are compared with the limited literature and further discussed.

title: Impairment and return to work after XXXX of the calcaneus.

answer: @entity3


abstract: OBJECTIVES: We report our experience about @entity1 management in a small hospital with no possibility of coronarography. MATERIALS AND METHODS: In 1998, 60 @entity0 were hospitalized for @entity1 < 10 days. We studied characteristics of @entity0 , the management of @entity1 , the mortality. RESULTS: Our population consisted of 83% of @entity0 and 17% of @entity0 with a mean age of 63.5 and 74 years respectively. An out-hospital doctor was first warned by 60% of @entity0 . For hospitalization, the emergency ambulance service (SMUR) was used in 45% of cases, out-hospital doctors using these means of transport in 36% of cases. The global time of intervention was 18h30. The mean time for @entity0 managed in the first sixth hours was 2h10. A thrombolysis was applied for 35% of @entity0 (15% in prehospital that is to say 32% of "SMUR @entity0 ", and 20% in hospital). A transfer to the neighbouring university hospital for primary or rescue coronary angioplasty was decide for 41% of @entity0 . A total of 77% of our @entity0 underwent a coronarography. The global mortality at 10 days was 13.3% (< 75 years: 10.6%; > 75 years: 23%). CONCLUSIONS: A low volume centre and with no possibility of coronarography can manage the acute phase of @entity1 with results closed to those of the literature.

title: [Acute XXXX management in a hospital center with emergency ambulance service and intensive care unit, without cardiac catheterization laboratory].

answer: @entity1


abstract: PURPOSE: To determine if a mailed health promotion program reduced outpatient visits while improving health status. DESIGN: Randomized controlled trial. SETTING: A midsized, group practice model, managed care organization in Ohio. SUBJECTS: Members invited (N = 3214) were high utilizers, 18 to 64 years old, with @entity3 , @entity2 , or @entity5 (or all). A total of 886 members agreed to participate, and 593 members returned the initial questionnaires. The 593 members were randomized to the following groups: 99 into @entity5 treatment and 100 into @entity5 control, 94 into blood pressure treatment and 92 into blood pressure control, and 104 into @entity2 treatment and 104 into @entity2 control. MEASURES: Outpatient utilization, health status, and self-efficacy were followed over 30 months. INTERVENTIONS: Health risk appraisal questionnaires were mailed to treatment and control groups before randomization and at 1 year. The treatment group received three additional condition-specific ( @entity5 , @entity2 , or @entity3 ) questionnaires and a health information handbook. The treatment group also received written health education materials and an individualized feedback letter after each returned questionnaire. The control group received condition-specific written health education materials and reimbursement for exercise equipment or fitness club membership after returning the 1-year end of the study questionnaire. RESULTS: Changes in visit rates were disease specific. Parameter estimates were calculated from a Poisson regression model. For intervention vs. controls, the @entity5 group decreased visits 4.84 per 30 months (p < 0.00), the @entity2 group had no significant change, and the @entity3 group increased visits 2.89 per 30 months (p < 0.05), the overall health status improved significantly (-6.5 vs. 2.3, p < 0.01) for the @entity5 group but showed no significant change for the other two groups, and @entity4 and @entity1 risk scores did not change significantly for any group individually. Overall self-efficacy for intervention group completers improved by -8.6 points (p < 0.03) for the @entity5 group, and the other groups showed no significant change. CONCLUSIONS: This study demonstrated that in a population of 18 to 64 years with chronic conditions, mailed health promotion programs might only benefit @entity0 with certain conditions.

title: The impact of a health education program targeting XXXX with high visit rates in a managed care organization.

answer: @entity0


abstract: The availability of @entity1 ( @entity1 ) cells isolated from @entity0 blastocysts may open novel avenues for medical treatment of otherwise incurable diseases. Yet the generation of @entity0 @entity1 cells requires the destruction of early @entity0 embryos. This confronts us with the moral problem of whether it is justifiable to sacrifice @entity0 life in order to treat other @entity0 life. This article outlines the development of the German debate about research with @entity1 cells and explicates the arguments that are central to that debate with respect to the aims and means of research with @entity1 cells. With regard to the means, the isolation of @entity1 cells from @entity0 embryos raises the question of the moral status of the @entity0 embryo. A restrictive position acknowledges the @entity0 dignity of the embryo in its very early stage of development and claims that the embryo's life must be protected accordingly. In contrast, a gradualist position acknowledges @entity0 dignity, and therefore the full level of protection, only when the embryo has reached a certain stage of development. In addition, the intentions behind the generation of @entity0 embryos, i.e. exclusively for research purposes, and the mode of generating them, i.e. by nuclear transfer technology, have strong ethical relevance in the German debate. Based on these results, the ethical reasoning underlying the draft of a Stem Cell Act recently passed by the German Parliament is outlined.

title: Principles of ethical decision making regarding XXXX cell research in Germany.

answer: @entity1


abstract: According to the Rubicon Model of Action Phases (in: J. Gollwitzer, 1996), Motivation, volition, and action, Enzyclopedia of psychology, series "motivation and emotion", Vol. 4, Hogrefe, G  ttingen, 1996, pp. 531-582), different stages in goal pursuit are accompanied by different mindsets that enhance processing of mindset-congruous information. Before @entity0 engage in action, they usually deliberate possible goals for a given situation (deliberative mindset). Once a goal is chosen, they plan how to achieve this particular goal (implemental mindset). The present experiments tested the hypothesis that @entity0 with social @entity1 show a reversal of mindsets when approaching social situations. In Experiment 1, 20 students were asked to either deliberate goals for a hypothetical social conflict (deliberation), or to think about steps to solve the conflict (implementation). An unexpected recognition test demonstrated different recognition memory for deliberation-related versus implementation-related information in the two groups, consistent with the hypothesis of different mindsets. In Experiment 2, 48 students who were either high or low in social @entity1 were randomly assigned to either the deliberation or the implementation condition. @entity0 high in social @entity1 showed a pattern in the recognition test that was consistent with a reversal of mindsets. When asked to plan social situations, they showed an inappropriate deliberative mindset. In contrast, they lacked a deliberative mindset when deliberating goals for the social situation. The result indicate that socially anxious @entity0 engage in information processing that interferes with successful goal attainment when approaching social situations.

title: Mindsets in social XXXX : a new look at selective information processing.

answer: @entity1


abstract: Obesity is a major chronic health problem in adults. It is a complex, @entity5 characterised by excess accumulation of adipose tissue. It is associated with a number of complications including @entity4 , @entity6 , @entity7 2 @entity2 , dyslipidaemia and @entity1 . A weight loss in the order of 5-10% is associated with clinically meaningful reductions with respect to all comorbidities. Diet and exercise has been the cornerstone of weight management therapy, but this approach has limitations, especially for weight maintenance. Previous drugs used in @entity3 had serious side effects including @entity8 . However, recent drugs like @entity9 and @entity10 have been rigorously tested and proven safe. @entity9 , a lipase inhibitor, inhibits absorption of dietary fat by approximately 30%. Taken with a hypocaloric diet, it produces and maintains clinically meaningful weight loss. @entity10 is a centrally-acting agent which enhances satiety and thermogenesis by inhibiting @entity11 and @entity12 re-uptake. It is appropriate for @entity0 who are unable to lose weight by lifestyle modification.

title: Pharmacological management of XXXX .

answer: @entity3


abstract: The rate of recurrence of @entity1 after classic antireflux surgery (fundoplication) is 10-15%. This rate is different in @entity0 with @entity4 with and without @entity2 . We evaluated the clinical and laboratory findings in 104 @entity0 with postoperative recurrent @entity1 , determining the results of repeat antireflux surgery or an acid suppression-bile diversion procedure. Repeat fundoplication was performed in 26 @entity0 , and truncal vagotomy, antrectomy, and Roux-en-Y gastrojejunostomy in 78 @entity0 . Esophagectomy as a third operation was performed in seven @entity0 . After repeat antireflux surgery, endoscopic evaluation demonstrated improvement of @entity4 in a small proportion of @entity0 . @entity2 remained unchanged, and no regression of @entity3 or stricture was observed. These complications improved significantly after acid suppression-bile diversion surgery. Incompetent lower esophageal sphincter (LES) was present in 55.8% after initial surgery and in 23% after reoperation. Acid reflux, initially present in 94.6% of @entity0 , was also observed in 93.6% after fundoplication, 68.8% after redo fundoplication, and 16.6% after treatment with the acid suppression-bile diversion technique. A positive Bilitec test was present in 78% of @entity0 before the operation and 56.6% after the repeat operation, and was negative after bile diversion surgery. Among 13 @entity0 (50%) submitted to repeat surgery alone, esophagectomy as a third operation was necessary as a result of severe non-dilatable stricture in seven @entity0 . Our conclusions are that repeat antireflux surgery alone failed to improve @entity2 and that the best results were obtained in @entity0 submitted to acid suppression-bile diversion surgery.

title: Results of surgical treatment for recurrent XXXX .

answer: @entity1


abstract: BACKGROUND: The progression of @entity2 from diagnosis of @entity4 2 @entity1 has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma @entity7 or renal replacement therapy (RRT), and @entity6 . METHODS: Using observed and modeled data from 5097 subjects in the UK Prospective @entity1 , we measured the annual probability of transition from stage to stage (incidence), prevalence, cumulative incidence, ten-year survival, median duration per stage, and risk of @entity6 from all-causes or @entity3 . RESULTS: From diagnosis of @entity1 , progression to microalbuminuria occurred at 2.0% per year, from microalbuminuria to macroalbuminuria at 2.8% per year, and from macroalbuminuria to elevated plasma @entity7 (>or=175 micromol/L) or renal replacement therapy at 2.3% per year. Ten years following diagnosis of @entity1 , the prevalence of microalbuminuria was 24.9%, of macroalbuminuria was 5.3%, and of elevated plasma @entity7 or RRT was 0.8%. @entity0 with elevated plasma @entity7 or RRT had an annual @entity6 rate of 19.2% (95% confidence interval, CI, 14.0 to 24.4%). There was a trend for increasing risk of @entity3 with increasing @entity2 (P < 0.0001), with an annual rate of 0.7% for subjects in the stage of no @entity2 , 2.0% for those with microalbuminuria, 3.5% for those with macroalbuminuria, and 12.1% with elevated plasma @entity7 or RRT. Individuals with macroalbuminuria were more likely to die in any year than to develop @entity5 . CONCLUSIONS: The proportion of @entity0 with @entity4 2 @entity1 who develop microalbuminuria is substantial with one quarter affected by 10 years from diagnosis. Relatively fewer @entity0 develop macroalbuminuria, but in those who do, the @entity6 rate exceeds the rate of progression to worse @entity2 .

title: Development and progression of XXXX in @entity4 2 @entity1 : the United Kingdom Prospective @entity1 (UKPDS 64).

answer: @entity2


abstract: BACKGROUND: The progression of @entity2 from diagnosis of @entity4 2 @entity1 has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma @entity7 or renal replacement therapy (RRT), and @entity6 . METHODS: Using observed and modeled data from 5097 subjects in the UK Prospective @entity1 , we measured the annual probability of transition from stage to stage (incidence), prevalence, cumulative incidence, ten-year survival, median duration per stage, and risk of @entity6 from all-causes or @entity3 . RESULTS: From diagnosis of @entity1 , progression to microalbuminuria occurred at 2.0% per year, from microalbuminuria to macroalbuminuria at 2.8% per year, and from macroalbuminuria to elevated plasma @entity7 (>or=175 micromol/L) or renal replacement therapy at 2.3% per year. Ten years following diagnosis of @entity1 , the prevalence of microalbuminuria was 24.9%, of macroalbuminuria was 5.3%, and of elevated plasma @entity7 or RRT was 0.8%. @entity0 with elevated plasma @entity7 or RRT had an annual @entity6 rate of 19.2% (95% confidence interval, CI, 14.0 to 24.4%). There was a trend for increasing risk of @entity3 with increasing @entity2 (P < 0.0001), with an annual rate of 0.7% for subjects in the stage of no @entity2 , 2.0% for those with microalbuminuria, 3.5% for those with macroalbuminuria, and 12.1% with elevated plasma @entity7 or RRT. Individuals with macroalbuminuria were more likely to die in any year than to develop @entity5 . CONCLUSIONS: The proportion of @entity0 with @entity4 2 @entity1 who develop microalbuminuria is substantial with one quarter affected by 10 years from diagnosis. Relatively fewer @entity0 develop macroalbuminuria, but in those who do, the @entity6 rate exceeds the rate of progression to worse @entity2 .

title: Development and progression of @entity2 in XXXX 2 @entity1 : the United Kingdom Prospective @entity1 (UKPDS 64).

answer: @entity4


abstract: BACKGROUND: The progression of @entity2 from diagnosis of @entity4 2 @entity1 has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma @entity7 or renal replacement therapy (RRT), and @entity6 . METHODS: Using observed and modeled data from 5097 subjects in the UK Prospective @entity1 , we measured the annual probability of transition from stage to stage (incidence), prevalence, cumulative incidence, ten-year survival, median duration per stage, and risk of @entity6 from all-causes or @entity3 . RESULTS: From diagnosis of @entity1 , progression to microalbuminuria occurred at 2.0% per year, from microalbuminuria to macroalbuminuria at 2.8% per year, and from macroalbuminuria to elevated plasma @entity7 (>or=175 micromol/L) or renal replacement therapy at 2.3% per year. Ten years following diagnosis of @entity1 , the prevalence of microalbuminuria was 24.9%, of macroalbuminuria was 5.3%, and of elevated plasma @entity7 or RRT was 0.8%. @entity0 with elevated plasma @entity7 or RRT had an annual @entity6 rate of 19.2% (95% confidence interval, CI, 14.0 to 24.4%). There was a trend for increasing risk of @entity3 with increasing @entity2 (P < 0.0001), with an annual rate of 0.7% for subjects in the stage of no @entity2 , 2.0% for those with microalbuminuria, 3.5% for those with macroalbuminuria, and 12.1% with elevated plasma @entity7 or RRT. Individuals with macroalbuminuria were more likely to die in any year than to develop @entity5 . CONCLUSIONS: The proportion of @entity0 with @entity4 2 @entity1 who develop microalbuminuria is substantial with one quarter affected by 10 years from diagnosis. Relatively fewer @entity0 develop macroalbuminuria, but in those who do, the @entity6 rate exceeds the rate of progression to worse @entity2 .

title: Development and progression of @entity2 in @entity4 2 XXXX : the United Kingdom Prospective @entity1 (UKPDS 64).

answer: @entity1


abstract: BACKGROUND: The progression of @entity2 from diagnosis of @entity4 2 @entity1 has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma @entity7 or renal replacement therapy (RRT), and @entity6 . METHODS: Using observed and modeled data from 5097 subjects in the UK Prospective @entity1 , we measured the annual probability of transition from stage to stage (incidence), prevalence, cumulative incidence, ten-year survival, median duration per stage, and risk of @entity6 from all-causes or @entity3 . RESULTS: From diagnosis of @entity1 , progression to microalbuminuria occurred at 2.0% per year, from microalbuminuria to macroalbuminuria at 2.8% per year, and from macroalbuminuria to elevated plasma @entity7 (>or=175 micromol/L) or renal replacement therapy at 2.3% per year. Ten years following diagnosis of @entity1 , the prevalence of microalbuminuria was 24.9%, of macroalbuminuria was 5.3%, and of elevated plasma @entity7 or RRT was 0.8%. @entity0 with elevated plasma @entity7 or RRT had an annual @entity6 rate of 19.2% (95% confidence interval, CI, 14.0 to 24.4%). There was a trend for increasing risk of @entity3 with increasing @entity2 (P < 0.0001), with an annual rate of 0.7% for subjects in the stage of no @entity2 , 2.0% for those with microalbuminuria, 3.5% for those with macroalbuminuria, and 12.1% with elevated plasma @entity7 or RRT. Individuals with macroalbuminuria were more likely to die in any year than to develop @entity5 . CONCLUSIONS: The proportion of @entity0 with @entity4 2 @entity1 who develop microalbuminuria is substantial with one quarter affected by 10 years from diagnosis. Relatively fewer @entity0 develop macroalbuminuria, but in those who do, the @entity6 rate exceeds the rate of progression to worse @entity2 .

title: Development and progression of @entity2 in @entity4 2 @entity1 : the United Kingdom Prospective XXXX (UKPDS 64).

answer: @entity1


abstract: @entity5 reportedly has little direct myocardial effect. However, because of interactions between the heart and vascular load, the effects on myocardial contractility and left ventricular @entity0 consumption (LVO2) have not been established. The authors performed experiments on six isolated, blood-perfused @entity1 left ventricles that were isovolumically contracting and paced at constant rate. @entity3 ( @entity3 ) and coronary blood flow were measured for evaluation of coronary vascular resistance, and coronary arteriovenous @entity0 difference was measured for determination of LVO2. Intracoronary injection of 1 and 10 micrograms of @entity5 decreased coronary vascular resistance by 16.9 and 36.8% ( @entity3 approximately 40 mm Hg), respectively, and by 21.5 and 47.7% ( @entity3 approximately 80 mm Hg). At both doses, @entity5 caused no decrease in peak systolic pressure as long as @entity3 was kept constant at 80 mm Hg. However, when @entity3 was decreased to 40 mm Hg, peak systolic pressure was significantly decreased even without @entity5 . This impaired contractile state was associated with a decreased coronary blood flow and a slight decrease in LVO2, whereas 10 micrograms of @entity5 at @entity3 approximately 80 mm Hg increased LVO2 significantly. Using the end-systolic pressure-volume relationship as an index of contractility, the authors found @entity5 not to change the contractile state at @entity3 approximately 80 mm Hg. They conclude that @entity5 decreases coronary vascular resistance over a wide range of @entity3 . It neither depresses the contractile state nor decreases LVO2 in the @entity1 left ventricle. @entity5 might effectively counteract @entity4 by dilating the coronary vessels without @entity2 myocardial contractility as found in this study on normal ventricle.

title: Effect of @entity5 on coronary resistance, contractility and XXXX consumption of the isolated blood-perfused @entity1 left ventricle.

answer: @entity0


abstract: @entity5 reportedly has little direct myocardial effect. However, because of interactions between the heart and vascular load, the effects on myocardial contractility and left ventricular @entity0 consumption (LVO2) have not been established. The authors performed experiments on six isolated, blood-perfused @entity1 left ventricles that were isovolumically contracting and paced at constant rate. @entity3 ( @entity3 ) and coronary blood flow were measured for evaluation of coronary vascular resistance, and coronary arteriovenous @entity0 difference was measured for determination of LVO2. Intracoronary injection of 1 and 10 micrograms of @entity5 decreased coronary vascular resistance by 16.9 and 36.8% ( @entity3 approximately 40 mm Hg), respectively, and by 21.5 and 47.7% ( @entity3 approximately 80 mm Hg). At both doses, @entity5 caused no decrease in peak systolic pressure as long as @entity3 was kept constant at 80 mm Hg. However, when @entity3 was decreased to 40 mm Hg, peak systolic pressure was significantly decreased even without @entity5 . This impaired contractile state was associated with a decreased coronary blood flow and a slight decrease in LVO2, whereas 10 micrograms of @entity5 at @entity3 approximately 80 mm Hg increased LVO2 significantly. Using the end-systolic pressure-volume relationship as an index of contractility, the authors found @entity5 not to change the contractile state at @entity3 approximately 80 mm Hg. They conclude that @entity5 decreases coronary vascular resistance over a wide range of @entity3 . It neither depresses the contractile state nor decreases LVO2 in the @entity1 left ventricle. @entity5 might effectively counteract @entity4 by dilating the coronary vessels without @entity2 myocardial contractility as found in this study on normal ventricle.

title: Effect of XXXX on coronary resistance, contractility and @entity0 consumption of the isolated blood-perfused @entity1 left ventricle.

answer: @entity5


abstract: @entity5 reportedly has little direct myocardial effect. However, because of interactions between the heart and vascular load, the effects on myocardial contractility and left ventricular @entity0 consumption (LVO2) have not been established. The authors performed experiments on six isolated, blood-perfused @entity1 left ventricles that were isovolumically contracting and paced at constant rate. @entity3 ( @entity3 ) and coronary blood flow were measured for evaluation of coronary vascular resistance, and coronary arteriovenous @entity0 difference was measured for determination of LVO2. Intracoronary injection of 1 and 10 micrograms of @entity5 decreased coronary vascular resistance by 16.9 and 36.8% ( @entity3 approximately 40 mm Hg), respectively, and by 21.5 and 47.7% ( @entity3 approximately 80 mm Hg). At both doses, @entity5 caused no decrease in peak systolic pressure as long as @entity3 was kept constant at 80 mm Hg. However, when @entity3 was decreased to 40 mm Hg, peak systolic pressure was significantly decreased even without @entity5 . This impaired contractile state was associated with a decreased coronary blood flow and a slight decrease in LVO2, whereas 10 micrograms of @entity5 at @entity3 approximately 80 mm Hg increased LVO2 significantly. Using the end-systolic pressure-volume relationship as an index of contractility, the authors found @entity5 not to change the contractile state at @entity3 approximately 80 mm Hg. They conclude that @entity5 decreases coronary vascular resistance over a wide range of @entity3 . It neither depresses the contractile state nor decreases LVO2 in the @entity1 left ventricle. @entity5 might effectively counteract @entity4 by dilating the coronary vessels without @entity2 myocardial contractility as found in this study on normal ventricle.

title: Effect of @entity5 on coronary resistance, contractility and @entity0 consumption of the isolated blood-perfused XXXX left ventricle.

answer: @entity1


abstract: 1. The effect of intravenous vasoactive intestinal peptide ( @entity7 , 6 pmol/kg per min) on renal function in six @entity0 with @entity6 was examined. 2. @entity7 caused generalized vasodilation and increased plasma @entity3 activity, but diminished the glomerular filtration rate by about one third. 3. The excretion of water, @entity5 , @entity4 and @entity2 also fell significantly. 4. These results differ from our findings in normal @entity0 in whom @entity7 diminished water and electrolyte secretion largely by increasing tubular reabsorption. 5. It is concluded that the elevated @entity7 levels present in @entity0 with severe @entity1 may affect renal function, but that the presence of @entity1 may affect renal responses to @entity7 .

title: Effects of vasoactive intestinal polypeptide infusions on renal function in @entity0 with XXXX .

answer: @entity1


abstract: 1. The effect of intravenous vasoactive intestinal peptide ( @entity7 , 6 pmol/kg per min) on renal function in six @entity0 with @entity6 was examined. 2. @entity7 caused generalized vasodilation and increased plasma @entity3 activity, but diminished the glomerular filtration rate by about one third. 3. The excretion of water, @entity5 , @entity4 and @entity2 also fell significantly. 4. These results differ from our findings in normal @entity0 in whom @entity7 diminished water and electrolyte secretion largely by increasing tubular reabsorption. 5. It is concluded that the elevated @entity7 levels present in @entity0 with severe @entity1 may affect renal function, but that the presence of @entity1 may affect renal responses to @entity7 .

title: Effects of vasoactive intestinal polypeptide infusions on renal function in XXXX with @entity1 .

answer: @entity0


abstract: Beh  et disease is relatively rare in pediatric age group. And the bowel involvement is seen in only a small portion of Beh  et disease. However, once the bowel is involved it is potentially life threatening event. We report a 15 year old @entity0 with intestinal Beh  et's disease who had a history of recurrent @entity5 for several years. He underwent right hemicolectomy under the impression of @entity4 . Pathologically the lesion was a large sharply delineated @entity2 in the cecum. The @entity2 was round and deep with elevating margin, and was associated with thickening of affected intestinal wall. Microscopically, the @entity2 base consisted of granulation tissue with fissurings and underminings. Characteristic @entity3 and occlusive @entity1 were seen in intestinal wall. The inflammatory lesion was most pronounced around the @entity2 but could be recognizable throughout the resected specimen.

title: Intestinal Beh  et's disease in a XXXX --a case report.

answer: @entity0


abstract: Lens capsule thickness was measured in 105 @entity1 lenses with and without @entity2 . The lenses were removed by intracapsular cryoextraction. Forty lenses (38%) showed exfoliation, while 65 (62%) were exfoliation negative. Thickness values were measured by light microscopy from the central anterior capsule, central posterior capsule and from the equator. The mean thickness values were for the central anterior capsule 8.2 +/- 3.2 mu, for the central posterior capsule 3.2 +/- 1.4 and for the equator 3.9 +/- 1.3. There was no statistical difference between the exfoliation-positive and exfoliation-negative lenses. The capsule thickness varied greatly throughout the present material. The highest value, 22.4 mu, was measured from an exfoliation-negative central anterior lens capsule of a male @entity0 aged 33 years. The lowest value, 0.6 mu, was measured from an exfoliation-positive central posterior capsule of a male @entity0 aged 64 years. The central posterior capsule is the thinnest area of the lens capsule. The findings call for great caution in polishing the posterior capsule during extracapsular @entity1 surgery. The higher complication rate in eyes with @entity2 cannot be explained by thinner lens capsules but rather on the more friable zonules.

title: Capsule thickness of XXXX lenses with and without @entity2 .

answer: @entity1


abstract: Lens capsule thickness was measured in 105 @entity1 lenses with and without @entity2 . The lenses were removed by intracapsular cryoextraction. Forty lenses (38%) showed exfoliation, while 65 (62%) were exfoliation negative. Thickness values were measured by light microscopy from the central anterior capsule, central posterior capsule and from the equator. The mean thickness values were for the central anterior capsule 8.2 +/- 3.2 mu, for the central posterior capsule 3.2 +/- 1.4 and for the equator 3.9 +/- 1.3. There was no statistical difference between the exfoliation-positive and exfoliation-negative lenses. The capsule thickness varied greatly throughout the present material. The highest value, 22.4 mu, was measured from an exfoliation-negative central anterior lens capsule of a male @entity0 aged 33 years. The lowest value, 0.6 mu, was measured from an exfoliation-positive central posterior capsule of a male @entity0 aged 64 years. The central posterior capsule is the thinnest area of the lens capsule. The findings call for great caution in polishing the posterior capsule during extracapsular @entity1 surgery. The higher complication rate in eyes with @entity2 cannot be explained by thinner lens capsules but rather on the more friable zonules.

title: Capsule thickness of @entity1 lenses with and without XXXX .

answer: @entity2


abstract: A 60-year-old @entity0 , who had been receiving chronic hemodialysis for @entity2 due to polycystic disease for 7 years, was admitted to our hospital with the chief complaints of right @entity6 and high-grade @entity3 on February 3, 1986. She had a family history of @entity1 and her elder sister has been undergoing chronic hemodialysis. The @entity0 has had repeated episodes of @entity4 . The right markedly distended kidney was palpated with severe @entity7 , and the performance status was poor. Computerized tomography showed the right kidney enlarging beyond the median line, but localization of the infected cysts was not clear. The 7-day intensive antibiotic therapy had no beneficial effect. On the 8th hospital day, percutaneous drainage, which was carried out for a large cyst with low-level echoes using ultrasonic guidance, yielded 600 ml of hemopurulent fluid. Bacterial culture of the aspirated fluid was positive for @entity5 . As the clinical symptoms did not improve after the 8th day, 10 Fr. catheter placement, percutaneous drainage and catheter placement were added for other cysts containing hemopurulent fluid. Although hematopyuria persisted, the @entity0 became afebrile and the right kidney became smaller and softer. Both catheters were removed on the 30th hospital day. Repeated computerized tomography or ultrasonography revealed a few hyperdense or hyperechoic @entity1 . However, no recurrence of high-grade @entity3 or right @entity6 has been seen for 3 months. Ultrasonic-guided percutaneous drainage has a great potential for @entity0 care of infected cysts in @entity1 .

title: [Successful percutaneous drainage for infected cysts in XXXX in a case of chronic hemodialysis].

answer: @entity1


abstract: The fate of 103 @entity0 consecutively operated upon for chronic @entity5 between 1978 and 1986 was examined with a multivariate statistical approach to verify the operative indications and results. In the early risk phase, up to 39 days after operation, 15 @entity0 (15%) died. Mortality was mostly due to a @entity4 and was significantly related to older age and to functional (NYHA) and anginal (CCS) class. In the late risk phase, starting 1.9 years after surgery, 9 @entity0 died (10%) and the significant risk factors were anterior @entity2 and older age at operation. Actuarial survival curves showed 82% survival at 5 years and 61% at 9.5 years. In 25 @entity0 older than 50 years and with an anterior @entity2 , these rates were 51% and 34%, respectively. Improved functional class was observed in 87% of the @entity0 interviewed, but 30% complained of @entity3 or new @entity6 . Survival free of @entity1 was 64% at 5 years and 13% at 9.5 years. This development of @entity1 recurrences was significantly related to older age and to incomplete revascularization despite multiple grafts. These results suggest modification of the grafting policy and of the techniques of repair in identified high-risk subsets.

title: Early and late determinants of survival after surgery of XXXX .

answer: @entity5


abstract: From November 1980 to November 1986, 63 @entity0 aged 4 months to 13 years (mean 3.4 years) underwent repair of anomalies of ventriculo-arterial connection with @entity3 and @entity4 , using a technique (REV) first described by us in 1982. The selection of @entity0 was based on preoperative criteria, namely the measurement of the distance between the tricuspid and the semilunar valves. These measurements enabled us to select from @entity0 with an abnormal ventriculo-arterial connection, those in whom the @entity1 could be repaired by intra-ventricular partition alone. In the remaining cases, REV was indicated in the presence of @entity2 . The principles of the technique are: (1) resection of the infundibular septum creating a large, direct and subarterial communication between the left ventricle and the aorta; (2) construction of a straight left ventricle to aorta tunnel by intraventricular partition; (3) direct anastomosis of the pulmonary trunk to the right ventricle. There were 12 hospital deaths (19%). The mean follow-up was 32 months. One @entity0 died suddenly 1 year after repair. Six @entity0 required reoperation. All survivors are in NYHA class I, except for 3 @entity0 who are in class II. No stenosis of the left ventricular outflow tract was found but 5 @entity0 had a significant pressure gradient at the pulmonary outflow tract level. Our present experience suggests that in properly selected @entity0 , REV allows anatomic repair in a wide variety of anomalies of the ventriculo-arterial connection associated with @entity3 and @entity4 with an acceptable rate of mortality and morbidity.

title: Anatomic repair of anomalies of ventriculo-arterial connection (REV). Results of a new technique in cases associated with XXXX .

answer: @entity4


abstract: One hundred and fifty @entity0 were assessed during an outbreak of @entity4 in Northern Italy. The aetiological agent was proved to be T. nelsoni. A detailed prospective rheumatological study was carried out. @entity6 was observed in 88 per cent, @entity5 in 60 per cent, @entity10 in 62 per cent and @entity9 in 20 per cent of the @entity0 . The @entity9 score was strictly related to @entity6 - @entity10 . The degree of @entity10 correlated with the degree of @entity8 . @entity2 in tissue samples was often observed in areas where eosinophils were the major cell population infiltrating the tissue. No relationship was seen between IgG antibody titers against Trichinella or IgE levels and clinical manifestations. @entity3 , @entity12 or @entity11 were not administered. We observed no CNS or heart involvement nor did we see @entity7 . After six months 18 @entity0 , with the highest degree of @entity10 and @entity8 had all improved. None showed abnormalities in laboratory tests and only four were still complaining of @entity2 . T. nelsoni-related @entity4 appears to induce @entity1 in the majority of @entity0 , but the long term course and prognosis is favourable.

title: Prospective rheumatological study of muscle and joint symptoms during XXXX .

answer: @entity4


abstract: The incidence of @entity7 , @entity2 and electrolyte disorders in 64 bone marrow transplant recipients randomized to receive either @entity4 or @entity6 was investigated. Sixty-four per cent of @entity0 developed @entity7 , 75 per cent @entity2 , and 88 per cent significant @entity8 . The incidence of diastolic @entity2 and @entity8 was greater in the patents treated with @entity4 . @entity8 was due to @entity9 wasting by the kidney. Both groups received similar cumulative doses of @entity11 antibiotics. Significant @entity5 developed in all but one @entity0 and @entity10 -range @entity5 was noted in 21 per cent. The cause of the @entity5 is unclear; no obvious morphologic changes were seen at autopsy in @entity0 who exhibited @entity10 -range @entity5 . The @entity1 were shown to be transient in @entity0 who were observed for periods ranging from one to three years. It is concluded that @entity2 , @entity3 and @entity8 are common in the setting of bone marrow transplantation. Whereas @entity4 probably aggravates the severity of these disorders, it is likely that other factors (e.g., @entity11 antibiotics) play a major role as shown by the high incidence of renal and electrolyte disorders in @entity0 treated with @entity6 alone.

title: @entity2 and XXXX in bone marrow transplant recipients.

answer: @entity1


abstract: The incidence of @entity7 , @entity2 and electrolyte disorders in 64 bone marrow transplant recipients randomized to receive either @entity4 or @entity6 was investigated. Sixty-four per cent of @entity0 developed @entity7 , 75 per cent @entity2 , and 88 per cent significant @entity8 . The incidence of diastolic @entity2 and @entity8 was greater in the patents treated with @entity4 . @entity8 was due to @entity9 wasting by the kidney. Both groups received similar cumulative doses of @entity11 antibiotics. Significant @entity5 developed in all but one @entity0 and @entity10 -range @entity5 was noted in 21 per cent. The cause of the @entity5 is unclear; no obvious morphologic changes were seen at autopsy in @entity0 who exhibited @entity10 -range @entity5 . The @entity1 were shown to be transient in @entity0 who were observed for periods ranging from one to three years. It is concluded that @entity2 , @entity3 and @entity8 are common in the setting of bone marrow transplantation. Whereas @entity4 probably aggravates the severity of these disorders, it is likely that other factors (e.g., @entity11 antibiotics) play a major role as shown by the high incidence of renal and electrolyte disorders in @entity0 treated with @entity6 alone.

title: XXXX and @entity1 in bone marrow transplant recipients.

answer: @entity2


abstract: Congenital cystic segmentary dilatation of the intrahepatic biliary ducts is a rare disease. Although several cases has been described in medical literature, its occurrence such as it was originally referred is exceptional. Some cases coexist with @entity6 and portal @entity2 . A characteristic phenomenon is the formation of stones and canalicular @entity3 . In this article, three cases of @entity9 (females, 57, 53 and 58 years old) are described. Case n 1 was a complex @entity4 including: a) cystic and segmentary dilatations of the intrahepatic biliar ducts; b) intra and @entity8 and recurrent infections; c) fusion of the choledocus and gallbladder in a common sac; d) hepatic cavernosus @entity5 and a supernumerarious lobe. Case n 2 showed: a) cystic and segmentary dilatation of the intrahepatic biliar ducts; b) portal @entity1 ; c) @entity7 ; d) portal @entity2 . Case n 3 showed: a) cystic and segmentary dilatation of the intrahepatic biliar ducts; b) portal @entity1 ; c) @entity7 and spleen; d) portal @entity2 . Prognostic of this @entity0 is variable and depends on the recurrent infections and the coexistence of other @entity4 which are frequently severe. Surgery is the only treatment for the disease although there are no definite conclusions concerning the long-term results.

title: [ XXXX : congenital cystic and segmentary dilatation of the intrahepatic bile ducts].

answer: @entity9


abstract: We report six @entity0 from our Intensive Care Unit with @entity4 ( @entity4 ) post @entity1 . There were 3 males and 3 females, mean age 57.8. None of them had prior @entity1 . Four @entity0 had recent onset angina and 2 had not previous angina. @entity1 was two-fold times more frequent than anterior wall @entity3 . Three @entity0 had right ventricular @entity3 . Early severe @entity2 was present in 85% of @entity0 , being sudden in onset in 3. In 2 @entity0 surgical closure of @entity4 was performed, being it successful in 1 with good long-term survival. In conclusion, @entity4 is a serious complication of @entity1 . Accuracy in diagnosis and solid therapeutic measures are required.

title: [Ventricular septal defect after XXXX ].

answer: @entity1


abstract: The purpose of this study is to review 30 @entity0 with failed, multiply operated knees, or knees with gross instability which were reconstructed using the expanded @entity2 ( @entity2 ) prosthetic ligament as a substitute for the ACL. The results were then compared with our experience with the proplast ligament used in a previous clinical series. This prospective review evaluated the @entity0 preoperatively and at regular intervals during the postoperative period. The average followup was 24 months postoperation. Eighty-three percent of the @entity0 had a satisfactory result, scoring greater than 140 points on a 200 point knee grading scale. Objectively, the anterior instability pattern was improved in 87% of the knees. Subjectively, @entity1 of at least a mild degree persisted in 70% of the @entity0 postoperatively. This @entity1 seemed to correlate with articular cartilage changes documented intraoperatively. Major complications occurred in two @entity0 . In conclusion, the @entity2 prosthetic ligament was an improvement over the proplast ligament in the reconstruction of the multiply operated, unstable knee. The 83% satisfactory rate with the @entity2 was promising compared to a 52% satisfactory rate using the proplast ligament. However, we encourage future long term studies of the @entity2 prosthetic ligament in the reconstruction of the ACL in the chronically unstable knee.

title: Anterior cruciate reconstruction in the chronically unstable knee using an expanded XXXX ( @entity2 ) prosthetic ligament.

answer: @entity2


abstract: The purpose of this study is to review 30 @entity0 with failed, multiply operated knees, or knees with gross instability which were reconstructed using the expanded @entity2 ( @entity2 ) prosthetic ligament as a substitute for the ACL. The results were then compared with our experience with the proplast ligament used in a previous clinical series. This prospective review evaluated the @entity0 preoperatively and at regular intervals during the postoperative period. The average followup was 24 months postoperation. Eighty-three percent of the @entity0 had a satisfactory result, scoring greater than 140 points on a 200 point knee grading scale. Objectively, the anterior instability pattern was improved in 87% of the knees. Subjectively, @entity1 of at least a mild degree persisted in 70% of the @entity0 postoperatively. This @entity1 seemed to correlate with articular cartilage changes documented intraoperatively. Major complications occurred in two @entity0 . In conclusion, the @entity2 prosthetic ligament was an improvement over the proplast ligament in the reconstruction of the multiply operated, unstable knee. The 83% satisfactory rate with the @entity2 was promising compared to a 52% satisfactory rate using the proplast ligament. However, we encourage future long term studies of the @entity2 prosthetic ligament in the reconstruction of the ACL in the chronically unstable knee.

title: Anterior cruciate reconstruction in the chronically unstable knee using an expanded @entity2 ( XXXX ) prosthetic ligament.

answer: @entity2


abstract: The clinical and pathological features of eight @entity4 with glandular patterns resembling those of @entity8 are described. The @entity0 ranged in age from 11 to 34 years (mean, 22 years) and presented with @entity6 or @entity2 . The serum @entity5 ( @entity5 ) level was elevated at the time of presentation or later in all seven @entity0 in whom it was measured. Seven @entity3 were unilateral, one was bilateral, and three had spread beyond the ovary. There was a contralateral streak gonad in two cases. The @entity3 were 6-35 cm in diameter; seven were solid and cystic, and one was a unilocular cyst with a small solid nodule in the wall. Microscopic examination revealed a prominent, and in two cases, pure endometrioid-like glandular pattern that often simulated that of an early secretory endometrium. @entity7 were also present in five @entity3 ; minor teratomatous foci (squamous epithelium and cartilage) were present in one. Immunohistochemical staining revealed @entity5 , alpha-1-anti-trypsin (AAT), and carcinoembryonic antigen within the glandular epithelium; @entity5 and AAT were also present in areas showing the other patterns. Three @entity0 died of recurrent or @entity1 19-60 months postoperatively; in the remaining cases, there was a @entity3 -free follow-up of short duration. The endometrioid-like pattern reflects an unusual form of @entity7 that should be distinguished from @entity8 .

title: Endometrioid-like variant of XXXX . A clinicopathological analysis of eight cases.

answer: @entity4


abstract: Warthin's @entity1 comprised 14 percent of all @entity1 operated on. The average @entity0 age in our series was 57.2 years. Eighty-seven percent of the @entity1 occurred in the parotid tail. The rest were in the deep lobe, or in an extraparotid location. Fifteen @entity0 had multifocal @entity1 . The maximum number of @entity1 foci in one @entity0 was six. A significant increase in the female incidence was noted with a 1.5:1 male-to-female ratio as compared with the previous male dominant ratio of 8:1. Eighty-two percent of the female @entity0 in our group were smokers. We correlated a very high incidence of cigarette smoking in our series when compared with age-matched groups in both sexes within the general population. Since it is estimated that one of eight @entity0 with @entity2 will have multifocal disease, we suggest wider exposure and more meticulous operative exploration to avoid overlooked @entity1 foci and subsequent recurrence.

title: XXXX : multicentricity and increasing incidence in @entity0 .

answer: @entity2


abstract: Warthin's @entity1 comprised 14 percent of all @entity1 operated on. The average @entity0 age in our series was 57.2 years. Eighty-seven percent of the @entity1 occurred in the parotid tail. The rest were in the deep lobe, or in an extraparotid location. Fifteen @entity0 had multifocal @entity1 . The maximum number of @entity1 foci in one @entity0 was six. A significant increase in the female incidence was noted with a 1.5:1 male-to-female ratio as compared with the previous male dominant ratio of 8:1. Eighty-two percent of the female @entity0 in our group were smokers. We correlated a very high incidence of cigarette smoking in our series when compared with age-matched groups in both sexes within the general population. Since it is estimated that one of eight @entity0 with @entity2 will have multifocal disease, we suggest wider exposure and more meticulous operative exploration to avoid overlooked @entity1 foci and subsequent recurrence.

title: @entity2 : multicentricity and increasing incidence in XXXX .

answer: @entity0


abstract: Male @entity0 experimentally infected with dengue @entity1 types 1, 2, 3, or 4 transmitted their infection sexually to female Ae. albopictus. Such transmission was enhanced if the females had taken a bloodmeal 2 to 7 days prior to mating. Male Ae. albopictus also transmitted dengue @entity1 vertically to their F1 progeny. Infected progeny were found among those derived from eggs laid greater than or equal to 73 hr after mating but not among those derived from eggs laid prior to that time. This suggests that @entity1 probably was not transmitted directly to ova but, rather, underwent prior replication in the female genital tract. Female Ae. albopictus experimentally infected with @entity1 did not transmit their infection sexually to males. This finding supports the hypothesis that male mosquitoes naturally infected with dengue @entity1 acquired their infection vertically.

title: Sexual transmission of dengue viruses by XXXX .

answer: @entity0