abstract: A 73-year-old @entity0 was admitted to our hospital with @entity3 and high grade fever on Aug, 1992. Physical examination revealed a @entity1 in the nasopharyngeal cavity, generalized skin eruptions and three @entity1 on different subcutaneous lesions, @entity2 2 cm below the costal margin, and the enlargement of the right cervical and axillary lymph nodes. Biopsy of the nasopharyngeal and cutaneous @entity1 disclosed @entity6 (WF: Diffuse small cleaved). Peripheral blood examination showed a WBC of 4,800/microliters with 10% blastoid cells. Bone marrow examination showed 60% blastoid cells which frequently appeared a hand mirror configuration had no azurophilic granules in the cytoplasm. Flow cytometic analysis of these cells in the bone marrow showed that they expressed @entity7 (NKH-1) and Ia but not expressed T-cell antigens as well as B-cell antigens and myeloid cell antigens. Phenotype of subcutaneous @entity1 biopsy cells was similar to that of blastoid cells in the bone marrow. T-cell receptor gene ( @entity8 and gamma) rearrangements in blastoid cells were not found. The @entity0 was treated with local radiotherapy to nasopharyngeal and @entity5 , followed by chemotherapy. The @entity0 died of complication with @entity3 due to DIC. These results suggested that this @entity4 derived from NK cell.

title: [Primary XXXX with CD3- and @entity7 + phenotype].

answer: @entity4


abstract: A 73-year-old @entity0 was admitted to our hospital with @entity3 and high grade fever on Aug, 1992. Physical examination revealed a @entity1 in the nasopharyngeal cavity, generalized skin eruptions and three @entity1 on different subcutaneous lesions, @entity2 2 cm below the costal margin, and the enlargement of the right cervical and axillary lymph nodes. Biopsy of the nasopharyngeal and cutaneous @entity1 disclosed @entity6 (WF: Diffuse small cleaved). Peripheral blood examination showed a WBC of 4,800/microliters with 10% blastoid cells. Bone marrow examination showed 60% blastoid cells which frequently appeared a hand mirror configuration had no azurophilic granules in the cytoplasm. Flow cytometic analysis of these cells in the bone marrow showed that they expressed @entity7 (NKH-1) and Ia but not expressed T-cell antigens as well as B-cell antigens and myeloid cell antigens. Phenotype of subcutaneous @entity1 biopsy cells was similar to that of blastoid cells in the bone marrow. T-cell receptor gene ( @entity8 and gamma) rearrangements in blastoid cells were not found. The @entity0 was treated with local radiotherapy to nasopharyngeal and @entity5 , followed by chemotherapy. The @entity0 died of complication with @entity3 due to DIC. These results suggested that this @entity4 derived from NK cell.

title: [Primary @entity4 with CD3- and XXXX + phenotype].

answer: @entity7


abstract: The distribution of @entity2 synthase immunoreactivity (NOS-IR) and the changes in this distribution after peripheral axotomy were examined in lumbosacral afferent and preganglionic neurons (PGNs) innervating the pelvic viscera of the male @entity0 . The visceral neurons in L6-S1 and L1-L2 dorsal root ganglia (DRG) and in the spinal cord were identified by retrograde axonal transport following injection of Fluorogold (FG) into the major @entity1 (MPG). Axotomy was performed by removing the MPG on one side 2-4 weeks prior to sacrificing the animals. A differential distribution of NOS-IR was detected in DRG cells at different segmental levels of control animals. Significantly greater numbers of NOS-IR cells were present in thoracic (T8, T10, T12; 30-44 cell profiles/section) and rostral lumbar DRGs (L1-L2; 3-15 NOS-IR cell profiles/section) compared to caudal lumbosacral (L5-S1) DRGs (0.2-0.7 cell profiles/section). A significant increase in the number of NOS-IR cells was detected in the L6-S1 DRG (p < or = 0.001; 11 NOS-IR cell profiles/section) but not in the L2 or L5 DRG ipsilateral to axotomy. In these ganglia, an average of 37.0 +/- 4.0% (L6) and 20.6 +/- 2.2% (S1), respectively, of FG-labeled pelvic afferent neurons were NOS-IR compared to 1.1 +/- 0.5% (L6) and 2.5 +/- 1.4% (S1) contralateral to the axotomy. Following axotomy, a significantly greater percentage of dye-labeled pelvic visceral afferents in the L1 and L2 DRG also exhibited NOS-IR in comparison to the contralateral side. Following axotomy, NOS-IR fibers were detected along the lateral edge of the dorsal horn extending from Lissauer's tract to the region of the sacral parasympathetic nucleus (SPN) on the ipsilateral side of the L6 and S1 spinal segments. These NOS-IR fibers were not detected in adjacent spinal segments (L4, L5, or S2). Axotomy also changed the numbers of @entity3 -d-positive and NOS-IR cells in the region of the SPN in the L6 spinal segment. Contralateral to the axotomy 38.3 +/- 4.0% of PGNs in the L6 spinal segment were colabeled with NOS-IR; however, ipsilateral to axotomy, a significantly greater percentage (61.0 +/- 3.0%; p < or = 0.01) of PGNs exhibited NOS-IR. Axotomy did not alter the distribution of PGNs in the S1 segment exhibiting NOS-IR. These results indicate that NOS-IR in visceral afferent and PGNs is plastic and can be upregulated by @entity4 .

title: Increased expression of neuronal XXXX synthase (NOS) in visceral neurons after nerve injury.

answer: @entity2


abstract: BACKGROUND: Textile @entity2 is a well-established entity, but there are relatively few Australian reports in this area. OBJECTIVES: To report the combined experience of textile contact @entity3 from the general and occupational contact @entity3 clinics at the Skin and Cancer Foundation, Melbourne, Victoria, Australia. @entity0 /METHODS: On the basis of the clinical suspicion of @entity2 , 2069 @entity0 were tested with a textile series. RESULTS: One hundred and fifty-seven (7.6%) @entity0 reacted to any of the textile-related allergens. The most common allergen was Basic Red 46 (20.2% of the positive reactions), followed by @entity5 and @entity6 (11.8% and 11.2%, respectively). Reactions to @entity1 and @entity1 -releasing chemicals accounted for 30.6% of the concomitant reactions, and reactions to @entity4 accounted for 12.6% of the concomitant reactions. The use of Disperse Blue mix yielded only 12.2% of @entity0 sensitive to either of these two allergens, and it is not endorsed as a screening agent for textile dye @entity2 . CONCLUSION: Textile @entity2 is not uncommon. In Melbourne, Basic Red 46 in inexpensive, dark-coloured, acrylic-blend, @entity0 's work socks is the most important cause. It is important to test with samples of @entity0 ' clothing.

title: Textile XXXX --the Melbourne experience.

answer: @entity2


abstract: AIMS: To characterize the frequency and the nature (symptomatic vs. asymptomatic) of hypoglycaemia in @entity0 with @entity2 1 @entity1 with impaired awareness of hypoglycaemia. METHODS: A group of 19 @entity0 with @entity2 1 @entity1 with normal hypoglycaemia awareness were matched for age, sex, duration of @entity1 and glycaemic control with 19 @entity0 with impaired awareness of hypoglycaemia. Frequency of severe hypoglycaemia in the preceding year was estimated retrospectively. Capillary blood @entity3 was monitored prospectively four times daily, over a 4-week period. All blood @entity3 values < 3 mmol/l were recorded and classified by symptom response. RESULTS: The @entity0 with impaired awareness of hypoglycaemia exhibited twice the frequency of all episodes of hypoglycaemia over the 4-week monitoring period than those with normal awareness (mean   sd 7.9    5.4 vs. 3.7    3.6, P =   0.003). No differences between the two subgroups were observed in the total number of symptomatic hypoglycaemia episodes (4.2    3.3 vs. 3.2    3.4, P = 0.25). The group with impaired awareness of hypoglycaemia had a sevenfold higher incidence of asymptomatic hypoglycaemia than those with normal awareness (3.7    5.3 vs. 0.5    1.2, P = 0.001); these episodes comprised 47% of all @entity3 values < 3.0 mmol/l in this group, compared with 14% in the normal awareness group. The annual prevalence of severe hypoglycaemia for @entity0 with impaired awareness of hypoglycaemia was 53% compared with 5% for @entity0 with normal awareness, and these @entity0 had a significantly higher incidence of severe events (1.6    2.8 vs. 0.1    0.3, P = 0.001). CONCLUSIONS: Adults with @entity2 1 @entity1 who have impaired awareness of hypoglycaemia are exposed to a much higher incidence of asymptomatic hypoglycaemia than those with normal awareness and are at higher risk of developing severe hypoglycaemia.

title: Frequency of symptomatic and asymptomatic hypoglycaemia in XXXX 1 @entity1 : effect of impaired awareness of hypoglycaemia.

answer: @entity2


abstract: AIMS: To characterize the frequency and the nature (symptomatic vs. asymptomatic) of hypoglycaemia in @entity0 with @entity2 1 @entity1 with impaired awareness of hypoglycaemia. METHODS: A group of 19 @entity0 with @entity2 1 @entity1 with normal hypoglycaemia awareness were matched for age, sex, duration of @entity1 and glycaemic control with 19 @entity0 with impaired awareness of hypoglycaemia. Frequency of severe hypoglycaemia in the preceding year was estimated retrospectively. Capillary blood @entity3 was monitored prospectively four times daily, over a 4-week period. All blood @entity3 values < 3 mmol/l were recorded and classified by symptom response. RESULTS: The @entity0 with impaired awareness of hypoglycaemia exhibited twice the frequency of all episodes of hypoglycaemia over the 4-week monitoring period than those with normal awareness (mean   sd 7.9    5.4 vs. 3.7    3.6, P =   0.003). No differences between the two subgroups were observed in the total number of symptomatic hypoglycaemia episodes (4.2    3.3 vs. 3.2    3.4, P = 0.25). The group with impaired awareness of hypoglycaemia had a sevenfold higher incidence of asymptomatic hypoglycaemia than those with normal awareness (3.7    5.3 vs. 0.5    1.2, P = 0.001); these episodes comprised 47% of all @entity3 values < 3.0 mmol/l in this group, compared with 14% in the normal awareness group. The annual prevalence of severe hypoglycaemia for @entity0 with impaired awareness of hypoglycaemia was 53% compared with 5% for @entity0 with normal awareness, and these @entity0 had a significantly higher incidence of severe events (1.6    2.8 vs. 0.1    0.3, P = 0.001). CONCLUSIONS: Adults with @entity2 1 @entity1 who have impaired awareness of hypoglycaemia are exposed to a much higher incidence of asymptomatic hypoglycaemia than those with normal awareness and are at higher risk of developing severe hypoglycaemia.

title: Frequency of symptomatic and asymptomatic hypoglycaemia in @entity2 1 XXXX : effect of impaired awareness of hypoglycaemia.

answer: @entity1


abstract: Commonly used procedures for reconstructing hypopharyngeal and cervical esophageal defects resulting from total laryngopharyngectomy (TL) are the gastric conduit or colon transposition as well as microvascularized free flaps. Herein we designed an alternative procedure utilizing bilateral platysma myocutaneous flaps (PMCFs) for the reconstruction of hypopharyngeal and cervical esophageal defects. This report summarizes the technical description of this procedure. TL and cervical esophagectomy were performed and bilateral PMCFs were harvested for reconstruction of hypopharyngeal and cervical esophageal defects in 25 @entity0 aged between 46 and 73 years (mean 58.7    16.2 years). All these @entity0 had @entity1 with involvement of the cervical esophagus. Operative time ranged from 176 to 382 minutes (average 243    91 minutes) and the mean intraoperative @entity4 was 294    119mL. There were six cases of @entity5 (24.0%) and two of them (8.0%) developed anastomotic stricture. Neither flap @entity2 nor postoperative death was observed. The majority of our @entity0 (68.0%) were restored to a normal unrestricted oral diet after surgery. The 3-year and 5-year actuarial survival rates were approximately 54.7% and 26.1%, respectively. We conclude that reconstruction of the cervical esophagus with bilateral PMCFs is a valuable method for treating advanced @entity3 .

title: Reconstruction of hypopharyngeal and cervical esophageal defect after resection of XXXX : a new technique based on the use of bilateral platysma myocutaneous flaps.

answer: @entity3


abstract: Target tissues for @entity1 hormones are responsive by virtue of and to the extent of their content of functional intracellular receptors. Recent years have seen a shift in considerations of the cellular dynamics and distribution of these receptors, with current views favoring predominant intranuclear localization in the intact cell. This paper summarizes our analyses of the microsomal @entity2 and @entity3 binding capability of @entity0 uterine and ventral prostate tissue, respectively; these studies have revealed a set of high affinity sites that may act as a conduit for @entity2 traversing the cell en route to the nucleus. These sites have many properties in common with cytosolic receptors, with the salient difference of a failure to activate to a more avid DNA-binding form under conditions which permit such activation of cytosolic receptors. The microsomal @entity2 -binding proteins also have appreciable affinity for @entity6 , another distinction from other known cellular @entity2 receptor species. Various experimental approaches were employed to demonstrate that the microsomal receptors were not simply cytosol contaminants; the most convincing evidence is the recent successful separation of the cytosolic and microsomal forms by differential @entity5 precipitation. Discrete subfractionation of subcellular components on successive @entity4 gradients, with simultaneous assessments of binding capability and marker enzyme concentrations, indicates that the major portion of the binding is localized within the vesicles of the endoplasmic reticulum free of significant plasma membrane contamination. The microsomal receptors are readily solubilized by extraction with high- or low-salt-containing buffers or with @entity1 . The residual microsomes following such extraction have the characteristics of saturable acceptor sites for cytosolic @entity2 -receptor complexes. The extent to which these sites will accept the cytosolic complexes is equal to the concentration of microsomal binding sites extracted. These observations suggest three possible roles for the microsomal receptor-like proteins: (a) modulation of @entity2 access to nuclear binding sites; (b) formation of functional complexes which diffuse to other extranuclear sites to alter non-genomic cellular processes; (c) regulation of nuclear concentration of @entity2 -receptor complexes by virtue of producing microsomal acceptor sites for uptake of free or loosely associated nuclear complexes, previously thought to exist in the cytoplasm.

title: Microsomal receptor for XXXX hormones: functional implications for nuclear activity.

answer: @entity1


abstract: BACKGROUND: To evaluate and compare the efficacy and @entity2 between combination of @entity1 and @entity4 (GC) and combination of @entity6 and @entity4 (VC) in the treatment of @entity0 with advanced @entity5 ( @entity5 ). METHODS: Sixty-seven @entity0 with locally advanced or metastatic @entity5 were enrolled into the study, with 32 @entity0 in GC group and 35 in VC group. @entity0 ' characteristics were similar between the two groups. They were given gemcitabine 1 000-1 250 mg/m  , or @entity6 25 mg/m   on days 1 and 8, and @entity4 80-100 mg/m   on days 1-3. The chemotherapy was repeated every 3 weeks as a cycle. RESULTS: An objective response rate of 37.5% was observed in GC arm versus 34.3% in VC arm (P=0.59). The 1-year survival rate was 38.7% in GC compared to 34.3% in VC (P=0.48). The median survival duration was 9.5 months for GC arm and 8.6 months for VC arm. Myelosuppression was the major dose-limiting @entity2 . The incidence of @entity7 was significantly higher in the VC group than that in DC group (P=0.01), while grade III/IV @entity3 occurred more frequently in the GC group than that in VC group (P=0.015). CONCLUSIONS: The GC combination is as equally active and well tolerated as the VC combination in the treatment of @entity0 with advanced @entity5 .

title: [ @entity1 plus XXXX versus @entity6 plus @entity4 in the treatment of advanced @entity5 ].

answer: @entity4


abstract: BACKGROUND: To evaluate and compare the efficacy and @entity2 between combination of @entity1 and @entity4 (GC) and combination of @entity6 and @entity4 (VC) in the treatment of @entity0 with advanced @entity5 ( @entity5 ). METHODS: Sixty-seven @entity0 with locally advanced or metastatic @entity5 were enrolled into the study, with 32 @entity0 in GC group and 35 in VC group. @entity0 ' characteristics were similar between the two groups. They were given gemcitabine 1 000-1 250 mg/m  , or @entity6 25 mg/m   on days 1 and 8, and @entity4 80-100 mg/m   on days 1-3. The chemotherapy was repeated every 3 weeks as a cycle. RESULTS: An objective response rate of 37.5% was observed in GC arm versus 34.3% in VC arm (P=0.59). The 1-year survival rate was 38.7% in GC compared to 34.3% in VC (P=0.48). The median survival duration was 9.5 months for GC arm and 8.6 months for VC arm. Myelosuppression was the major dose-limiting @entity2 . The incidence of @entity7 was significantly higher in the VC group than that in DC group (P=0.01), while grade III/IV @entity3 occurred more frequently in the GC group than that in VC group (P=0.015). CONCLUSIONS: The GC combination is as equally active and well tolerated as the VC combination in the treatment of @entity0 with advanced @entity5 .

title: [ @entity1 plus @entity4 versus @entity6 plus XXXX in the treatment of advanced @entity5 ].

answer: @entity4


abstract: BACKGROUND: To evaluate and compare the efficacy and @entity2 between combination of @entity1 and @entity4 (GC) and combination of @entity6 and @entity4 (VC) in the treatment of @entity0 with advanced @entity5 ( @entity5 ). METHODS: Sixty-seven @entity0 with locally advanced or metastatic @entity5 were enrolled into the study, with 32 @entity0 in GC group and 35 in VC group. @entity0 ' characteristics were similar between the two groups. They were given gemcitabine 1 000-1 250 mg/m  , or @entity6 25 mg/m   on days 1 and 8, and @entity4 80-100 mg/m   on days 1-3. The chemotherapy was repeated every 3 weeks as a cycle. RESULTS: An objective response rate of 37.5% was observed in GC arm versus 34.3% in VC arm (P=0.59). The 1-year survival rate was 38.7% in GC compared to 34.3% in VC (P=0.48). The median survival duration was 9.5 months for GC arm and 8.6 months for VC arm. Myelosuppression was the major dose-limiting @entity2 . The incidence of @entity7 was significantly higher in the VC group than that in DC group (P=0.01), while grade III/IV @entity3 occurred more frequently in the GC group than that in VC group (P=0.015). CONCLUSIONS: The GC combination is as equally active and well tolerated as the VC combination in the treatment of @entity0 with advanced @entity5 .

title: [ @entity1 plus @entity4 versus @entity6 plus @entity4 in the treatment of advanced XXXX ].

answer: @entity5


abstract: BACKGROUND: To evaluate and compare the efficacy and @entity2 between combination of @entity1 and @entity4 (GC) and combination of @entity6 and @entity4 (VC) in the treatment of @entity0 with advanced @entity5 ( @entity5 ). METHODS: Sixty-seven @entity0 with locally advanced or metastatic @entity5 were enrolled into the study, with 32 @entity0 in GC group and 35 in VC group. @entity0 ' characteristics were similar between the two groups. They were given gemcitabine 1 000-1 250 mg/m  , or @entity6 25 mg/m   on days 1 and 8, and @entity4 80-100 mg/m   on days 1-3. The chemotherapy was repeated every 3 weeks as a cycle. RESULTS: An objective response rate of 37.5% was observed in GC arm versus 34.3% in VC arm (P=0.59). The 1-year survival rate was 38.7% in GC compared to 34.3% in VC (P=0.48). The median survival duration was 9.5 months for GC arm and 8.6 months for VC arm. Myelosuppression was the major dose-limiting @entity2 . The incidence of @entity7 was significantly higher in the VC group than that in DC group (P=0.01), while grade III/IV @entity3 occurred more frequently in the GC group than that in VC group (P=0.015). CONCLUSIONS: The GC combination is as equally active and well tolerated as the VC combination in the treatment of @entity0 with advanced @entity5 .

title: [ @entity1 plus @entity4 versus XXXX plus @entity4 in the treatment of advanced @entity5 ].

answer: @entity6


abstract: BACKGROUND: To evaluate and compare the efficacy and @entity2 between combination of @entity1 and @entity4 (GC) and combination of @entity6 and @entity4 (VC) in the treatment of @entity0 with advanced @entity5 ( @entity5 ). METHODS: Sixty-seven @entity0 with locally advanced or metastatic @entity5 were enrolled into the study, with 32 @entity0 in GC group and 35 in VC group. @entity0 ' characteristics were similar between the two groups. They were given gemcitabine 1 000-1 250 mg/m  , or @entity6 25 mg/m   on days 1 and 8, and @entity4 80-100 mg/m   on days 1-3. The chemotherapy was repeated every 3 weeks as a cycle. RESULTS: An objective response rate of 37.5% was observed in GC arm versus 34.3% in VC arm (P=0.59). The 1-year survival rate was 38.7% in GC compared to 34.3% in VC (P=0.48). The median survival duration was 9.5 months for GC arm and 8.6 months for VC arm. Myelosuppression was the major dose-limiting @entity2 . The incidence of @entity7 was significantly higher in the VC group than that in DC group (P=0.01), while grade III/IV @entity3 occurred more frequently in the GC group than that in VC group (P=0.015). CONCLUSIONS: The GC combination is as equally active and well tolerated as the VC combination in the treatment of @entity0 with advanced @entity5 .

title: [ XXXX plus @entity4 versus @entity6 plus @entity4 in the treatment of advanced @entity5 ].

answer: @entity1


abstract: Soccer is a game that demands a combination of repeated maximal sprinting wit with 10 to 11km of moderate running, sometimes performed under extremely warm conditions. Over the course of a match, there is partial to near complete depletion of glycogen reserves in the leg muscles (depending on the extent of initial reserves and the level of competition), with a resultant decrease in physical performance. Blood @entity0 levels also fall, sometimes to values likely to cause a deterioration of both tactical thinking and cooperation between players (3.0 to 3.8 mmol/L), while in tropical climates, fluid losses can amount to 4 to 5kg of bodyweight. The effectiveness of @entity0 solutions in correcting these problems is limited for 2 main reasons: concentrations greater than 2.5% slow the rate of gastric emptying and thus fluid absorption, while provoking a secretion of @entity3 with a resultant hypoglycaemia. @entity1 solutions are less liable to increase @entity3 secretion, but they have an equal propensity for slowing gastric emptying; moreover, the ingested @entity1 is largely metabolised in the liver, without boosting blood @entity0 . However, @entity0 polymer preparations have a low osmotic pressure per unit content of @entity0 equivalent, so that substantial amounts of @entity2 can be administered in this fashion before gastric emptying is inhibited. If polymers are given before and during a soccer game, they sustain blood @entity0 , sparing muscle glycogen stores and increasing game performance. If the concentration of polymer is too high, one possible complication is a movement of water from the plasma into the gut; nevertheless, with an appropriate choice of concentration (for example, 7% polycose, 360 mOsm/L, plasma volume is increased rather than decreased relative to that seen with administration of water. Probably because the intergame interval for competitive soccer players is short, replenishment of glycogen reserves proceeds quite slowly. Moreover, this process does not seem to be helped by ingestion of either @entity0 polymers or a high @entity2 diet.

title: XXXX and fluid needs of the soccer player.

answer: @entity2


abstract: Accelerated allograft @entity10 (chronic rejection) has emerged as a major factor affecting long-term survival of @entity0 cardiac allografts. The underlying mechanism of this disorder remains unclear. The purpose of this study was to investigate the effect of @entity2 on the development of @entity4 at the cellular and molecular level. Heterotopic @entity1 cardiac allografts from DA donors to WF recipients, with a strong genetic disparity in major histocompatibility complex and non-major histocompatibility complex loci, were used. The allograft recipients received triple-drug immunosuppression consisting of @entity9 (0.5 mg/kg/day), @entity5 (2 mg/kg/day), and three different doses of @entity2 ( @entity6 ; 5, 10, and 20 mg/kg/day). The grafts were removed 3 months after transplantation and processed for histology and immunohistochemistry. Low dose @entity6 (5 mg/kg/day) was associated with a severe form of intimal cell accumulation and intimal thickening in epicardial arteries and in smaller intramyocardial arterioles with nearly occluded vessel lumens 3 months after transplantation. The intermediate dose @entity6 (10 mg/kg/day) significantly inhibited arterial intimal thickening but was not efficient in reducing intimal cell accumulation. Instead, high dose @entity6 (20 mg/kg/day) significantly inhibited all arteriosclerotic vascular wall changes in the allografts. Immunohistochemistry revealed that the occluded epicardial arteries of cardiac allografts with low dose @entity6 expressed @entity3 on the endothelium. Higher @entity6 doses significantly reduced the expression of endothelial @entity3 . Neither @entity8 nor major histocompatibility complex class II were expressed. Perivascular arterial infiltrates consisting of T helper cells and monocytes/macrophages were a characteristic finding in the allograft with low dose @entity6 . In the allografts treated with higher doses of @entity6 , arterial perivascular infiltrates were seldom seen. Our results conclusively demonstrate that sufficient immunosuppression with @entity6 inhibits intimal thickening and intimal cell accumulation of long-surviving @entity1 cardiac allografts in a dose-dependent fashion. @entity7 alterations associated with increased expression of arterial endothelial @entity3 were totally down-regulated by high doses of @entity6 .

title: How XXXX modifies histological and molecular events in the vascular wall during chronic rejection of @entity1 cardiac allografts.

answer: @entity2


abstract: Accelerated allograft @entity10 (chronic rejection) has emerged as a major factor affecting long-term survival of @entity0 cardiac allografts. The underlying mechanism of this disorder remains unclear. The purpose of this study was to investigate the effect of @entity2 on the development of @entity4 at the cellular and molecular level. Heterotopic @entity1 cardiac allografts from DA donors to WF recipients, with a strong genetic disparity in major histocompatibility complex and non-major histocompatibility complex loci, were used. The allograft recipients received triple-drug immunosuppression consisting of @entity9 (0.5 mg/kg/day), @entity5 (2 mg/kg/day), and three different doses of @entity2 ( @entity6 ; 5, 10, and 20 mg/kg/day). The grafts were removed 3 months after transplantation and processed for histology and immunohistochemistry. Low dose @entity6 (5 mg/kg/day) was associated with a severe form of intimal cell accumulation and intimal thickening in epicardial arteries and in smaller intramyocardial arterioles with nearly occluded vessel lumens 3 months after transplantation. The intermediate dose @entity6 (10 mg/kg/day) significantly inhibited arterial intimal thickening but was not efficient in reducing intimal cell accumulation. Instead, high dose @entity6 (20 mg/kg/day) significantly inhibited all arteriosclerotic vascular wall changes in the allografts. Immunohistochemistry revealed that the occluded epicardial arteries of cardiac allografts with low dose @entity6 expressed @entity3 on the endothelium. Higher @entity6 doses significantly reduced the expression of endothelial @entity3 . Neither @entity8 nor major histocompatibility complex class II were expressed. Perivascular arterial infiltrates consisting of T helper cells and monocytes/macrophages were a characteristic finding in the allograft with low dose @entity6 . In the allografts treated with higher doses of @entity6 , arterial perivascular infiltrates were seldom seen. Our results conclusively demonstrate that sufficient immunosuppression with @entity6 inhibits intimal thickening and intimal cell accumulation of long-surviving @entity1 cardiac allografts in a dose-dependent fashion. @entity7 alterations associated with increased expression of arterial endothelial @entity3 were totally down-regulated by high doses of @entity6 .

title: How @entity2 modifies histological and molecular events in the vascular wall during chronic rejection of XXXX cardiac allografts.

answer: @entity1


abstract: BACKGROUND: Ascites is a common sequela of advanced or recurrent gynecologic @entity1 , such as @entity9 , or endometrium. Symptomatic treatment with repeated paracentesis is the initial management after failure of chemotherapy. STUDY DESIGN: This study was done to evaluate the safety and effectiveness of a peritoneovenous shunt (PVS) in the palliation of these @entity0 with recurrent @entity6 . A retrospective review of 25 @entity0 having a PVS between 1982 and 1992 was performed. RESULTS: The 25 @entity0 consisted of 21 @entity0 with @entity2 , two with @entity3 of the peritoneum, one with @entity7 , and one @entity0 with @entity9 . The mean weight and abdominal girth decreased after shunt insertion (p < 0.001). @entity4 and @entity8 also improved with PVS insertion. There was no change in mean Karnofsky score after placement of a PVS. Two @entity0 died within ten days postoperatively. The median survival period was 80 days and @entity5 occurred in four @entity0 . CONCLUSIONS: The insertion of a PVS is effective in relieving refractory @entity1 in gynecologic @entity1 . The impact on quality of life requires further study.

title: Peritoneovenous shunt for palliation of gynecologic XXXX .

answer: @entity1


abstract: The hydrothermal vent clam Calyptogena magnifica (Bivalvia: Mollusca) is a member of the Vesicomyidae. Species within this family form symbioses with chemosynthetic Gammaproteobacteria. They exist in environments such as hydrothermal vents and cold seeps and have a rudimentary gut and feeding groove, indicating a large @entity3 on their endosymbionts for nutrition. The C. magnifica symbiont, @entity5 , was the first intracellular @entity2 -oxidizing endosymbiont to have its genome sequenced (Newton et al. 2007). Here we expand upon the original report and provide additional details complying with the emerging MIGS/MIMS standards. The complete genome exposed the genetic blueprint of the metabolic capabilities of the symbiont. Genes which were predicted to encode the proteins required for all the metabolic pathways typical of free-living chemoautotrophs were detected in the symbiont genome. These include major pathways including @entity0 fixation, @entity2 oxidation, @entity4 assimilation, as well as @entity1 and cofactor/vitamin biosynthesis. This genome sequence is invaluable in the study of these enigmatic associations and provides insights into the origin and evolution of autotrophic endosymbiosis.

title: Complete genome sequence of XXXX .

answer: @entity5


abstract: BACKGROUND: @entity1 microenvironments present significant barriers to penetration by antibodies and immunoconjugates. @entity1 microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in vivo and an alternative research model more representative of the in vivo @entity1 is more desirable. SS1P is an immunotoxin composed of the Fv portion of a mesothelin-specific antibody fused to a bacterial toxin that is presently undergoing clinical trials in @entity3 . METHODOLOGY/PRINCIPAL FINDINGS: Here, we examined how the @entity1 microenvironment affects the penetration and killing activity of SS1P in a new three-dimensional (3D) spheroid model cultured in vitro using the @entity0 @entity3 cell line ( @entity0 ) and two primary cell lines isolated from the ascites of @entity4 @entity0 . Mesothelioma cells grown as monolayers or as spheroids expressed comparable levels of mesothelin; however, spheroids were at least 100 times less affected by SS1P. To understand this disparity in @entity2 , we made fluorescence-labeled SS1P molecules and used confocal microscopy to examine the time course of SS1P penetration within spheroids. The penetration was limited after 4 hours. Interestingly, we found a significant increase in the number of tight junctions in the core area of spheroids by electron microscopy. Expression of @entity5 , a protein involved in the assembly and sealing of tight junctions and highly expressed in @entity4 , was found significantly increased in spheroids as compared to monolayers. Moreover, we found that siRNA silencing and antibody inhibition targeting @entity5 could enhance SS1P immunotoxin therapy in vitro. CONCLUSION/SIGNIFICANCE: This work is one of the first to investigate immunotoxins in 3D @entity1 spheroids in vitro. This initial description of an in vitro @entity1 model may offer a simple and more representative model of in vivo @entity1 and will allow for further investigations of the microenvironmental effects on drug penetration and @entity1 cell killing. We believe that the methods developed here may apply to the studies of other @entity1 -targeting antibodies and immunoconjugates in vitro.

title: The development and characterization of a @entity0 XXXX in vitro 3D model to investigate immunotoxin therapy.

answer: @entity3


abstract: BACKGROUND: @entity1 microenvironments present significant barriers to penetration by antibodies and immunoconjugates. @entity1 microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than those grown in vivo and an alternative research model more representative of the in vivo @entity1 is more desirable. SS1P is an immunotoxin composed of the Fv portion of a mesothelin-specific antibody fused to a bacterial toxin that is presently undergoing clinical trials in @entity3 . METHODOLOGY/PRINCIPAL FINDINGS: Here, we examined how the @entity1 microenvironment affects the penetration and killing activity of SS1P in a new three-dimensional (3D) spheroid model cultured in vitro using the @entity0 @entity3 cell line ( @entity0 ) and two primary cell lines isolated from the ascites of @entity4 @entity0 . Mesothelioma cells grown as monolayers or as spheroids expressed comparable levels of mesothelin; however, spheroids were at least 100 times less affected by SS1P. To understand this disparity in @entity2 , we made fluorescence-labeled SS1P molecules and used confocal microscopy to examine the time course of SS1P penetration within spheroids. The penetration was limited after 4 hours. Interestingly, we found a significant increase in the number of tight junctions in the core area of spheroids by electron microscopy. Expression of @entity5 , a protein involved in the assembly and sealing of tight junctions and highly expressed in @entity4 , was found significantly increased in spheroids as compared to monolayers. Moreover, we found that siRNA silencing and antibody inhibition targeting @entity5 could enhance SS1P immunotoxin therapy in vitro. CONCLUSION/SIGNIFICANCE: This work is one of the first to investigate immunotoxins in 3D @entity1 spheroids in vitro. This initial description of an in vitro @entity1 model may offer a simple and more representative model of in vivo @entity1 and will allow for further investigations of the microenvironmental effects on drug penetration and @entity1 cell killing. We believe that the methods developed here may apply to the studies of other @entity1 -targeting antibodies and immunoconjugates in vitro.

title: The development and characterization of a XXXX @entity3 in vitro 3D model to investigate immunotoxin therapy.

answer: @entity0


abstract: OBJECTIVE: @entity3 following @entity1 is common, with negative consequences for functional outcome. However, existing studies typically do not include quantitative measures of discriminative sensibility. The aim of this study was to quantify the proportion of @entity1 @entity0 presenting with discriminative sensory loss of the hand in the post-acute rehabilitation phase. DESIGN: Prospective cohort study of @entity1 survivors presenting for rehabilitation. @entity0 : Fifty-one consecutive @entity0 admitted to a metropolitan rehabilitation centre over a continuous 12-month period who met selection criteria. METHODS: Quantitative measures of touch discrimination and limb position sense, with high re-test reliability, good discriminative test properties and objective criteria of abnormality, were employed. Both upper limbs were tested, in counterbalanced order. RESULTS: Impaired touch discrimination was identified in the hand contralateral to the lesion in 47% of @entity0 , and in the ipsilesional hand in 16%. Forty-nine percent showed @entity2 sense in the contralesional limb and 20% in the ipsilesional limb. Sixty-seven percent demonstrated impairment of at least one modality in the contralesional limb. Ipsilesional impairment was less severe. CONCLUSION: Discriminative sensory impairment was quantified in the contralesional hand in approximately half of @entity1 @entity0 presenting for rehabilitation. A clinically significant number also experienced @entity2 "unaffected" hand.

title: Frequency of discriminative sensory loss in the hand after XXXX in a rehabilitation setting.

answer: @entity1


abstract: OBJECTIVES: To describe the @entity3 ( @entity3 ) knowledge and risk behaviors, and to determine factors related to condom use among male commercial sex workers (CSW) and male tourist clients in Bali, Indonesia. DESIGN: Individual survey interviews were conducted with a sample of 80 male CSW and 100 tourist clients in the Kuta area of Bali. METHODS: Survey interviews included detailed questions on @entity2 / @entity3 knowledge, @entity1 , and psychosocial measures related to risk taking. RESULTS: Most of the male CSW had heard about @entity2 and other @entity3 , although some misconceptions about transmission and risks of different sexual practices remained. Both oral and anal intercourse with tourists were common and condom use was far from consistent. Factors related to condom use for anal intercourse with tourist clients were condom beliefs, self efficacy, susceptibility to @entity3 , and @entity3 knowledge. Tourist clients were mainly from Australia and Europe and many had paid for sex in other parts of Indonesia as well as in high prevalence countries. Knowledge of @entity2 / @entity3 was very good among the tourists and previous experience with @entity3 was common. Factors related to condom use with male CSW were condom beliefs and self efficacy. CONCLUSION: There is a very active and mobile group of male CSW and tourist clients present in Bali. Interventions with these @entity0 are needed due to the low level of knowledge about @entity2 among CSW, their experience with @entity3 and @entity3 symptoms, and their level of risky @entity1 .

title: XXXX knowledge, risk behaviors, and factors related to condom use among male commercial sex workers and male tourist clients in Bali, Indonesia.

answer: @entity2


abstract: To avoid anticoagulation and minimize @entity6 phenomena, between 1975 and 1980 we used 18 porcine bioprosthetic valves (BPVs) to replace 11 aortic and seven mitral valves in 17 @entity0 ranging from 7 to 18 years of age (mean, 8.2 years). Ten BPVs (91%) in the aortic position had to be replaced one to six years (mean, 4.2 years) after insertion. Nine of these valves developed severe @entity4 with leaflet immobility and severe @entity5 . The tenth valve became insufficient with a disrupted cusp. Six (86%) of seven BPVs inserted in the mitral position required replacement two to four years (mean, 3.1 years) after insertion. Massive @entity1 developed in three, while in the other three @entity7 was prominent. All explanted BPVs exhibited @entity4 with disruption and loss of mobility of the leaflets. Hemodynamic deterioration often occurred catastrophically, with nine @entity0 requiring @entity2 . Elective valve replacement carried no hospital mortality, whereas @entity2 carried a 33% mortality. The @entity8 failure rate of 94% within six years leads us to recommend against the use of biologic valves in the pediatric age group in the aortic or mitral position. @entity3 may occur catastrophically and replacement should be carried out early to avoid the higher operative mortality associated with emergency surgery.

title: Fate of left-sided cardiac bioprosthesis valves in XXXX .

answer: @entity0


abstract: A double-blind controlled clinical trial on the medical treatment of the acute episode of duodenal @entity2 and the prevention of symptomatic relapses was performed. A total of 164 @entity0 with active duodenal @entity2 were either treated with @entity4 1 g/day (70 @entity0 ), @entity7 ( @entity6 ) 1.5 g/day (64 @entity0 ) or @entity6 2.5 g/day (30 @entity0 ). @entity6 is an allegedly protective agent stimulating mucosal @entity3 synthesis. Cumulative healing rates after 4 weeks in the 3 groups were 66, 28 and 28% and after 8 weeks 94, 70 and 63%, respectively. One hundred and five @entity0 with healed duodenal @entity2 received, in a second double-blind study, either @entity6 0.5 g/day or placebo. Thus, @entity2 was more rapid with @entity4 than with @entity6 . @entity6 did not prevent relapses. No presenting characteristic was associated with slow healing. Three presenting characteristics--smoking, teetotalling and @entity1 episode in the past--were associated with early symptomatic relapse. The present study was compared with a previous study performed by the same group of investigators using a similar study protocol. In both trials, an early relapse was associated with smoking. No other presenting characteristic was identified which in both trials was associated with slow healing or early symptomatic relapse. Thus, smoking appears to be the only one of the commonly available presenting characteristics which allows a prediction of the course of @entity5 .

title: Presenting characteristics of @entity0 with duodenal @entity2 and outcome of medical treatment in controlled clinical trials using @entity4 and diethylamine persilate to treat XXXX attack and diethylamine persilate and placebo to prevent relapses.

answer: @entity2


abstract: A double-blind controlled clinical trial on the medical treatment of the acute episode of duodenal @entity2 and the prevention of symptomatic relapses was performed. A total of 164 @entity0 with active duodenal @entity2 were either treated with @entity4 1 g/day (70 @entity0 ), @entity7 ( @entity6 ) 1.5 g/day (64 @entity0 ) or @entity6 2.5 g/day (30 @entity0 ). @entity6 is an allegedly protective agent stimulating mucosal @entity3 synthesis. Cumulative healing rates after 4 weeks in the 3 groups were 66, 28 and 28% and after 8 weeks 94, 70 and 63%, respectively. One hundred and five @entity0 with healed duodenal @entity2 received, in a second double-blind study, either @entity6 0.5 g/day or placebo. Thus, @entity2 was more rapid with @entity4 than with @entity6 . @entity6 did not prevent relapses. No presenting characteristic was associated with slow healing. Three presenting characteristics--smoking, teetotalling and @entity1 episode in the past--were associated with early symptomatic relapse. The present study was compared with a previous study performed by the same group of investigators using a similar study protocol. In both trials, an early relapse was associated with smoking. No other presenting characteristic was identified which in both trials was associated with slow healing or early symptomatic relapse. Thus, smoking appears to be the only one of the commonly available presenting characteristics which allows a prediction of the course of @entity5 .

title: Presenting characteristics of @entity0 with duodenal XXXX and outcome of medical treatment in controlled clinical trials using @entity4 and diethylamine persilate to treat @entity2 attack and diethylamine persilate and placebo to prevent relapses.

answer: @entity2


abstract: A double-blind controlled clinical trial on the medical treatment of the acute episode of duodenal @entity2 and the prevention of symptomatic relapses was performed. A total of 164 @entity0 with active duodenal @entity2 were either treated with @entity4 1 g/day (70 @entity0 ), @entity7 ( @entity6 ) 1.5 g/day (64 @entity0 ) or @entity6 2.5 g/day (30 @entity0 ). @entity6 is an allegedly protective agent stimulating mucosal @entity3 synthesis. Cumulative healing rates after 4 weeks in the 3 groups were 66, 28 and 28% and after 8 weeks 94, 70 and 63%, respectively. One hundred and five @entity0 with healed duodenal @entity2 received, in a second double-blind study, either @entity6 0.5 g/day or placebo. Thus, @entity2 was more rapid with @entity4 than with @entity6 . @entity6 did not prevent relapses. No presenting characteristic was associated with slow healing. Three presenting characteristics--smoking, teetotalling and @entity1 episode in the past--were associated with early symptomatic relapse. The present study was compared with a previous study performed by the same group of investigators using a similar study protocol. In both trials, an early relapse was associated with smoking. No other presenting characteristic was identified which in both trials was associated with slow healing or early symptomatic relapse. Thus, smoking appears to be the only one of the commonly available presenting characteristics which allows a prediction of the course of @entity5 .

title: Presenting characteristics of @entity0 with duodenal @entity2 and outcome of medical treatment in controlled clinical trials using XXXX and diethylamine persilate to treat @entity2 attack and diethylamine persilate and placebo to prevent relapses.

answer: @entity4


abstract: A double-blind controlled clinical trial on the medical treatment of the acute episode of duodenal @entity2 and the prevention of symptomatic relapses was performed. A total of 164 @entity0 with active duodenal @entity2 were either treated with @entity4 1 g/day (70 @entity0 ), @entity7 ( @entity6 ) 1.5 g/day (64 @entity0 ) or @entity6 2.5 g/day (30 @entity0 ). @entity6 is an allegedly protective agent stimulating mucosal @entity3 synthesis. Cumulative healing rates after 4 weeks in the 3 groups were 66, 28 and 28% and after 8 weeks 94, 70 and 63%, respectively. One hundred and five @entity0 with healed duodenal @entity2 received, in a second double-blind study, either @entity6 0.5 g/day or placebo. Thus, @entity2 was more rapid with @entity4 than with @entity6 . @entity6 did not prevent relapses. No presenting characteristic was associated with slow healing. Three presenting characteristics--smoking, teetotalling and @entity1 episode in the past--were associated with early symptomatic relapse. The present study was compared with a previous study performed by the same group of investigators using a similar study protocol. In both trials, an early relapse was associated with smoking. No other presenting characteristic was identified which in both trials was associated with slow healing or early symptomatic relapse. Thus, smoking appears to be the only one of the commonly available presenting characteristics which allows a prediction of the course of @entity5 .

title: Presenting characteristics of XXXX with duodenal @entity2 and outcome of medical treatment in controlled clinical trials using @entity4 and diethylamine persilate to treat @entity2 attack and diethylamine persilate and placebo to prevent relapses.

answer: @entity0


abstract: Previous studies have shown that intravenous @entity4 does modify @entity5 development, reduce @entity7 . To assess the clinical efficacy of an oral dosage regimen with 800 mg @entity4 five times daily, double-blind, placebo-controlled studies were carried out at three centres within the U.K., using a common protocol. According to inclusion criteria (immune competent @entity0 over 60 years of age with a clinical diagnosis of @entity6 with @entity5 of no more than 72 h duration, no previous systemic antiviral treatment, no history of @entity3 ) 205 @entity0 were recruited after they had given their informed consent. @entity0 were randomly assigned to receive either two 400 mg tablets @entity4 (41 @entity0 , 59 @entity0 ) or matching placebo (46 @entity0 , 59 @entity0 ) five times daily for seven days. Treatment was predominantly domiciliary based. According to clinical assessment and @entity2 score @entity4 recipients showed a significant benefit in terms of reduction in @entity5 progression if treatment was started within 48 h of the onset of @entity5 , and alleviation of @entity2 during the acute phase of @entity6 . Overall, the number of @entity0 developing @entity1 was significantly lower in the @entity4 group than in the placebo group (p = 0.02). However, there were no significant differences in @entity5 progression and @entity2 response in @entity0 with @entity6 affecting the ophthalmic division of the trigeminal nerve in @entity0 who received @entity4 (n = 21) compared to those who received placebo (n = 32). 12 @entity4 and 13 placebo recipients reported symptoms, predominantly gastrointestinal in nature, possibly or probably related to therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Oral XXXX for acute herpes zoster infections in immune-competent adults.

answer: @entity4


abstract: Surgery is still the single most important treatment modality for @entity0 . Even if some @entity1 with early stage @entity2 are treated, and in a clinical sense cured, by surgery alone, adjuvant local and systemic treatments are required for most @entity1 for the best possible @entity2 control. Surgery must be compatible and timed with other treatment modalities. It helps provide local control, which in some cases is enough for cure but in others is limited to being a means of palliation. Surgery provides the clinical team with material for diagnosis, for prognostication and for help in clinical decision making. The choice of the surgical procedure and its performance should be handled by surgeons, knowledgeable and interested in the field in order to obtain the best possible functional and cosmetic results. An algorithm for deciding the appropriate surgical treatment of the breast is presented. Surgical treatment of the axilla is controversial. Current debate indicates that exploration of the axilla can be safely omitted in some @entity1 groups, but more research is needed. Other important areas for clinical surgical research are use of immediate breast reconstruction, choice of management when margins are involved with @entity2 growth after breast-sparing operations, and surgical @entity2 which have been treated with chemotherapy preoperatively.

title: Role of surgery in invasive XXXX .

answer: @entity0


abstract: Conventionally raised crossbred Hampshire @entity2 were vaccinated orally with attenuated @entity3 in combination with an anthelmintic, @entity4 or @entity6 . @entity2 in group I (n = 9) were treated with @entity4 and vaccinated with attenuated @entity3 and those in group II (n = 9) were treated with @entity4 and permitted to commingle (contact exposure) with group I. @entity2 in group III (n = 9) were vaccinated in a similar manner and were treated with @entity6 . @entity2 in group IV (n = 9) were treated with @entity6 and permitted to commingle with group III. Control @entity2 (group V; n = 9) were not given any anthelmintic, nor were they vaccinated; they were housed separately. During the 8-week interval between vaccination and challenge inoculation, 4 total days and 8 total days of @entity0 were observed in @entity2 in groups I and II, respectively. Likewise, 5 total days and 10 total days of @entity0 were seen in groups III and IV, respectively. In all groups, the @entity2 tended to shed the organism in their feces after they were vaccinated or challenge inoculated, as determined by a @entity1 ( @entity1 ) and @entity5 ( @entity5 ). Overall mean shedding patterns of 5.5% and 24.5% identified by @entity5 and @entity1 , respectively, were seen in the 2 @entity4 -treated groups (I and II). In contrast, mean shedding patterns of 4% and 18% of the isolation attempts were detected by @entity5 and @entity1 , respectively, in the 2 @entity6 -treated groups. @entity0 and shedding of @entity3 in the controls (group V) did not occur.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of XXXX on the clinical and immunologic responses to oral vaccine of @entity3 .

answer: @entity4


abstract: Conventionally raised crossbred Hampshire @entity2 were vaccinated orally with attenuated @entity3 in combination with an anthelmintic, @entity4 or @entity6 . @entity2 in group I (n = 9) were treated with @entity4 and vaccinated with attenuated @entity3 and those in group II (n = 9) were treated with @entity4 and permitted to commingle (contact exposure) with group I. @entity2 in group III (n = 9) were vaccinated in a similar manner and were treated with @entity6 . @entity2 in group IV (n = 9) were treated with @entity6 and permitted to commingle with group III. Control @entity2 (group V; n = 9) were not given any anthelmintic, nor were they vaccinated; they were housed separately. During the 8-week interval between vaccination and challenge inoculation, 4 total days and 8 total days of @entity0 were observed in @entity2 in groups I and II, respectively. Likewise, 5 total days and 10 total days of @entity0 were seen in groups III and IV, respectively. In all groups, the @entity2 tended to shed the organism in their feces after they were vaccinated or challenge inoculated, as determined by a @entity1 ( @entity1 ) and @entity5 ( @entity5 ). Overall mean shedding patterns of 5.5% and 24.5% identified by @entity5 and @entity1 , respectively, were seen in the 2 @entity4 -treated groups (I and II). In contrast, mean shedding patterns of 4% and 18% of the isolation attempts were detected by @entity5 and @entity1 , respectively, in the 2 @entity6 -treated groups. @entity0 and shedding of @entity3 in the controls (group V) did not occur.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of @entity4 on the clinical and immunologic responses to oral vaccine of XXXX .

answer: @entity3


abstract: The genetic diversity of @entity0 strains was studied by using 30 isolates obtained from nodules on @entity0 growing in uninoculated fields over a wide geographic range. The following taxonomic approaches were used: DNA-DNA relatedness analysis, restriction fragment length polymorphism analysis of the amplified 16S ribosomal DNA (rDNA) intergenic spacer (IGS), and total 16S rRNA sequence analysis. The division of @entity0 -infective strains into two major phylogenetic groups (groups A and B) that has been described previously was confirmed by the polymorphism of the 16S IGS rDNA. We identified a total of five genomic species, including the previously described species @entity2 . All of the group B strains except one were homogeneous and belonged to a single genomic species corresponding to @entity2 . Group A was heterogeneous, containing three genomic species and five strains that remained unclassified, and its members had very different PCR restriction fragment length polymorphism profiles. The complete 16S rRNA sequences of strains representing the two major groups, @entity2 UPM-Ca7T (T = type strain) and genomic species 2 strain UPM-Ca36T, exhibited 19 mismatches. Both of these strains belonged to the @entity1 -Rhizobium huakuii branch; @entity2 UPM-Ca7T was closely related to @entity1 , and strain UPM-Ca36T was clearly separated from @entity2 and closely related to R. huakuii. Thus, genomic species 2 could be distinguished from @entity2 by its 16S rRNA sequence, by DNA relatedness data, by the polymorphism of the 16S IGS rDNAs, and by previously described multilocus enzyme electrophoresis results and phenotypic characteristics. Therefore, we propose that strains belonging to genomic species 2 should be classified in a new species, Rhizobium mediterraneum, and that strain UPM-Ca36 should be the type strain.

title: Genomic heterogeneity of strains nodulating XXXX ( @entity0 .) and description of Rhizobium mediterraneum sp. nov.

answer: @entity0


abstract: The genetic diversity of @entity0 strains was studied by using 30 isolates obtained from nodules on @entity0 growing in uninoculated fields over a wide geographic range. The following taxonomic approaches were used: DNA-DNA relatedness analysis, restriction fragment length polymorphism analysis of the amplified 16S ribosomal DNA (rDNA) intergenic spacer (IGS), and total 16S rRNA sequence analysis. The division of @entity0 -infective strains into two major phylogenetic groups (groups A and B) that has been described previously was confirmed by the polymorphism of the 16S IGS rDNA. We identified a total of five genomic species, including the previously described species @entity2 . All of the group B strains except one were homogeneous and belonged to a single genomic species corresponding to @entity2 . Group A was heterogeneous, containing three genomic species and five strains that remained unclassified, and its members had very different PCR restriction fragment length polymorphism profiles. The complete 16S rRNA sequences of strains representing the two major groups, @entity2 UPM-Ca7T (T = type strain) and genomic species 2 strain UPM-Ca36T, exhibited 19 mismatches. Both of these strains belonged to the @entity1 -Rhizobium huakuii branch; @entity2 UPM-Ca7T was closely related to @entity1 , and strain UPM-Ca36T was clearly separated from @entity2 and closely related to R. huakuii. Thus, genomic species 2 could be distinguished from @entity2 by its 16S rRNA sequence, by DNA relatedness data, by the polymorphism of the 16S IGS rDNAs, and by previously described multilocus enzyme electrophoresis results and phenotypic characteristics. Therefore, we propose that strains belonging to genomic species 2 should be classified in a new species, Rhizobium mediterraneum, and that strain UPM-Ca36 should be the type strain.

title: Genomic heterogeneity of strains nodulating @entity0 ( XXXX .) and description of Rhizobium mediterraneum sp. nov.

answer: @entity0


abstract: Streptokinase (1 million international units) was given intravenously over 30 or 60 minutes to 50 @entity0 four hours or less after the onset of @entity2 . All were aged less than or equal to 70 years and had 4 mm or greater ST segment elevation in anterior or inferior leads. Rapid (mean 95 min) ST segment resolution, which was taken to indicate reperfusion of the myocardium, occurred in 36 (72%) @entity0 . In these 36 the average time from onset of symptoms to peak @entity5 kinase, @entity5 kinase MB, and myoglobin was 9.45 hours, whereas it was 17 hours in the 14 @entity0 in whom indirect criteria did not indicate reperfusion. Reperfusion @entity6 were invariably present and @entity7 developed in five @entity0 and @entity9 in two. The @entity8 related artery was seen to be open in 28 (70%) of the 40 @entity0 who had delayed coronary arteriography. The frequency of patency in the @entity8 related artery was no different in @entity0 given streptokinase less than 2 hours or between 2-4 hours from onset of symptoms nor did it differ when streptokinase was infused over 30 or 60 minutes. Mean left ventricular ejection fraction was 57% in those with a @entity0 @entity8 related artery and 48% in those with an occluded vessel. Eight @entity0 subsequently underwent elective percutaneous transluminal coronary angioplasty after successful thrombolysis and six had coronary artery bypass grafting. There were nine in-hospital reocclusions of the @entity8 related coronary arteries. Two @entity1 episodes occurred; one required transfusion. Five of the 50 @entity0 died in hospital. All of them had had an anterior @entity2 ; four had @entity3 and one had @entity4 . During follow up, four @entity0 died, two suddenly and two from reinfarction. During follow up (mean 15 months) the frequency of reinfarction, dyspnoea, and angina was low and there was no difference in the proportions of @entity0 returning to work between those with an open @entity8 related artery and those with a closed @entity8 related artery. Intravenous administration of high dose streptokinase to selected @entity0 during the acute phase of @entity2 is a safe, effective, and practical method of thrombolysis. It must, however, be followed by coronary arteriography to select those @entity0 in whom percutaneous transluminal coronary angioplasty or coronary artery bypass grafting will be helpful.

title: High dose intravenous streptokinase in XXXX --short and long term prognosis.

answer: @entity2


abstract: The Wolfram, or @entity11 , syndrome is a rare @entity2 that is associated with @entity6 , @entity4 of an early onset, bilateral @entity5 and @entity7 . @entity10 are usually present as well. We have studied nine @entity0 belonging to five different families. All of the family members were HLA typed (including DR), and islet cell as well as antinuclear antibody determinations were carried out. Although individuals with @entity4 are very prone to have either HLA- @entity8 or - @entity9 antigens, none of our @entity0 had @entity8 antigens and only one was @entity9 positive. On the other hand, three of our @entity0 were typed as HLA-DR2 positive. This antigen is uncommon in classical insulin dependent @entity1 . In one of the families, the affected siblings did not share the same HLA haplotype. Islet cell and antinuclear antibodies were not found in any of the cases and six of the @entity0 had a small, but significant, insulin secretory reserve. On the basis of some of the clinical features it was also possible to further distinguish between the @entity11 and the classical @entity4 . The differences encountered between classical and @entity4 --the presence/absence of HLA linkage, HLA-DR2, - @entity8 and - @entity9 associations, islet cell or antinuclear antibodies, the tendency to @entity3 and @entity1 --indicate that their etiopathogenies are triggered by distinct mechanisms.

title: Contrasting features of XXXX associated with neuroectodermal defects and classical @entity4 .

answer: @entity4


abstract: The Wolfram, or @entity11 , syndrome is a rare @entity2 that is associated with @entity6 , @entity4 of an early onset, bilateral @entity5 and @entity7 . @entity10 are usually present as well. We have studied nine @entity0 belonging to five different families. All of the family members were HLA typed (including DR), and islet cell as well as antinuclear antibody determinations were carried out. Although individuals with @entity4 are very prone to have either HLA- @entity8 or - @entity9 antigens, none of our @entity0 had @entity8 antigens and only one was @entity9 positive. On the other hand, three of our @entity0 were typed as HLA-DR2 positive. This antigen is uncommon in classical insulin dependent @entity1 . In one of the families, the affected siblings did not share the same HLA haplotype. Islet cell and antinuclear antibodies were not found in any of the cases and six of the @entity0 had a small, but significant, insulin secretory reserve. On the basis of some of the clinical features it was also possible to further distinguish between the @entity11 and the classical @entity4 . The differences encountered between classical and @entity4 --the presence/absence of HLA linkage, HLA-DR2, - @entity8 and - @entity9 associations, islet cell or antinuclear antibodies, the tendency to @entity3 and @entity1 --indicate that their etiopathogenies are triggered by distinct mechanisms.

title: Contrasting features of @entity4 associated with neuroectodermal defects and classical XXXX .

answer: @entity4


abstract: @entity6 has now been shown to produce an increase in @entity3 release in a number of species, including @entity0 . Our work suggests that @entity6 is capable of producing this effect by a direct action on the @entity3 -secreting juxtaglomerular cells of the kidney. We have found no evidence to support the possibility that @entity6 produces this effect as a neurotransmitter in the kidney. In this regard, it should be noted that @entity6 has been identified as a cotransmitter primarily in cholinergic neurons. The kidney is thought to lack cholinergic innervation, and @entity4 has no effect on @entity3 secretion. We have explored two conditions where @entity3 secretion is known to increase and found that circulating levels of @entity6 did not increase along with the increase in PRA. Thus, at least in @entity2 and dietary @entity5 restriction, @entity6 does not appear to affect @entity3 secretion through a humoral mechanism. There could be other untested situations where a humoral effect of @entity6 might come into play since we have shown that the whole animal is capable of increasing plasma @entity6 to levels that affect @entity3 release. Studies employing recently developed @entity6 antagonists have the potential to determine in which physiological or pathological situations @entity6 contributes to the control of @entity3 secretion. For example, in @entity1 , plasma levels of both @entity6 and PRA are significantly elevated. Could the increase in PRA be partly dependent on an action of circulating @entity6 ?

title: Vasoactive intestinal peptide and XXXX secretion.

answer: @entity3


abstract: Twenty-one @entity0 with chronic @entity1 (CUC) or @entity6 underwent total colectomy, rectal mucosectomy, @entity8 formation and @entity2 of the pouch to the dentate line. Eleven (52%) intraoperative problems occurred. No deaths resulted. Ten (48%) @entity3 were treated without operative intervention. Ten @entity3 required a minor or major procedure to remedy the problem. The most common major complications were four small @entity7 . The only septic complication was a single wound @entity4 . Functional results have been satisfactory with 14 of 19 (74%) having six or fewer bowel movements per day. Most @entity0 do not wear perineal pads either day or night. Only one @entity0 felt his lifestyle had worsened. Seventeen of 19 (90%) @entity0 were satisfied with their result and would choose to have the operation again. Frequent diarrheal stools associated with @entity5 was the primary reason for a failure and excision of one pouch. This procedure is becoming the alternative of choice for CUC and @entity6 because of the ability to cure the disease as well as preserve anal sphincter function.

title: A review of twenty-one rectal mucosectomy and XXXX pull through procedures.

answer: @entity8


abstract: OBJECTIVE: The prognostic significance of recanalisation of a chronically occluded @entity4 @entity6 remains controversial, in contrast to early re-opening of the @entity4 vessel in the acute state of @entity4 . It was the purpose of this prospective study to discover whether successful recanalisation in the former influences the incidence of @entity2 ( @entity1 , @entity4 , by-pass operation) and clinical symptoms in the long term. @entity0 AND METHOD: Recanalisation procedures were successful in 58, unsuccessful in 41 of 99 @entity0 (81 @entity0 , 18 @entity0 ; mean age 55 [28-79] years) with anterior wall (n = 53) or posterior wall (n = 46) @entity3 (AMI and PMI, respectively). The two groups were similar with respect to age, sex, left-ventricular function, indication, exercise capacity and premedication. But the interval between @entity4 and recanalisation was shorter in the @entity0 who had successful recanalisation (5.1 +/- 5.3 vs 7.8 +/- 7.6 months; P < 0.05). Mean follow-up period for all @entity0 was 55.8 +/- 8.9 months after the recanalisation procedure. RESULTS: There were significantly fewer @entity2 after successful than failed recanalisation, both for the total group of @entity0 (5% vs 23%; P < 0.01) and those with @entity5 (9 vs 36%; P = 0.012). In the @entity0 with PMI there was only a trend in favour of those with successful recanalisation (0% vs 14%; P = 0.058). Symptomatic improvement was reported by 73% of @entity0 after successful but only 40% after failed recanalisation (P < 0.01). CONCLUSION: The results provide pointers towards prognostic indications of recanalisation even after chronic occlusion of the @entity4 vessel. The procedure should therefore be attempted if the occlusion is morphologically suitable.

title: [The recanalization of the chronically occluded XXXX @entity6 . The reduction of @entity2 in long-term clinical follow-up].

answer: @entity4


abstract: OBJECTIVE: The prognostic significance of recanalisation of a chronically occluded @entity4 @entity6 remains controversial, in contrast to early re-opening of the @entity4 vessel in the acute state of @entity4 . It was the purpose of this prospective study to discover whether successful recanalisation in the former influences the incidence of @entity2 ( @entity1 , @entity4 , by-pass operation) and clinical symptoms in the long term. @entity0 AND METHOD: Recanalisation procedures were successful in 58, unsuccessful in 41 of 99 @entity0 (81 @entity0 , 18 @entity0 ; mean age 55 [28-79] years) with anterior wall (n = 53) or posterior wall (n = 46) @entity3 (AMI and PMI, respectively). The two groups were similar with respect to age, sex, left-ventricular function, indication, exercise capacity and premedication. But the interval between @entity4 and recanalisation was shorter in the @entity0 who had successful recanalisation (5.1 +/- 5.3 vs 7.8 +/- 7.6 months; P < 0.05). Mean follow-up period for all @entity0 was 55.8 +/- 8.9 months after the recanalisation procedure. RESULTS: There were significantly fewer @entity2 after successful than failed recanalisation, both for the total group of @entity0 (5% vs 23%; P < 0.01) and those with @entity5 (9 vs 36%; P = 0.012). In the @entity0 with PMI there was only a trend in favour of those with successful recanalisation (0% vs 14%; P = 0.058). Symptomatic improvement was reported by 73% of @entity0 after successful but only 40% after failed recanalisation (P < 0.01). CONCLUSION: The results provide pointers towards prognostic indications of recanalisation even after chronic occlusion of the @entity4 vessel. The procedure should therefore be attempted if the occlusion is morphologically suitable.

title: [The recanalization of the chronically occluded @entity4 XXXX . The reduction of @entity2 in long-term clinical follow-up].

answer: @entity6


abstract: OBJECTIVE: The prognostic significance of recanalisation of a chronically occluded @entity4 @entity6 remains controversial, in contrast to early re-opening of the @entity4 vessel in the acute state of @entity4 . It was the purpose of this prospective study to discover whether successful recanalisation in the former influences the incidence of @entity2 ( @entity1 , @entity4 , by-pass operation) and clinical symptoms in the long term. @entity0 AND METHOD: Recanalisation procedures were successful in 58, unsuccessful in 41 of 99 @entity0 (81 @entity0 , 18 @entity0 ; mean age 55 [28-79] years) with anterior wall (n = 53) or posterior wall (n = 46) @entity3 (AMI and PMI, respectively). The two groups were similar with respect to age, sex, left-ventricular function, indication, exercise capacity and premedication. But the interval between @entity4 and recanalisation was shorter in the @entity0 who had successful recanalisation (5.1 +/- 5.3 vs 7.8 +/- 7.6 months; P < 0.05). Mean follow-up period for all @entity0 was 55.8 +/- 8.9 months after the recanalisation procedure. RESULTS: There were significantly fewer @entity2 after successful than failed recanalisation, both for the total group of @entity0 (5% vs 23%; P < 0.01) and those with @entity5 (9 vs 36%; P = 0.012). In the @entity0 with PMI there was only a trend in favour of those with successful recanalisation (0% vs 14%; P = 0.058). Symptomatic improvement was reported by 73% of @entity0 after successful but only 40% after failed recanalisation (P < 0.01). CONCLUSION: The results provide pointers towards prognostic indications of recanalisation even after chronic occlusion of the @entity4 vessel. The procedure should therefore be attempted if the occlusion is morphologically suitable.

title: [The recanalization of the chronically occluded @entity4 @entity6 . The reduction of XXXX in long-term clinical follow-up].

answer: @entity2


abstract: AIM: The study was designed to characterise more exactly the complex syndrome of exercise-induced @entity1 and @entity5 in order to obtain guidelines for their management. METHODS: 30 @entity0 (18 @entity0 and 12 @entity0 with physical exercise-induced @entity1 and @entity5 were investigated by questionnaire. The following items were of particular interest: age and sex; age at first manifestation; type, duration and intensity of the precipitating activity; type, duration and sequence of symptoms; prophylactic or therapeutic measures as cofactors. RESULTS: Initial symptoms occurred at an average age of 22 (7-50) years. Atopy was present in 70%. Jogging (60%), ball games (40%) and walking (27%) were the most frequent precipitating activities. On each occasion symptoms began a few minutes to hours after the start of the exercise. During a typical episode an average of eight symptoms were observed, most frequently affecting the skin ( @entity2 , angiooedema, @entity6 and @entity1 ), dyspnoea and @entity3 . @entity4 occurred in nine @entity0 : before they lost consciousness they noted at least two prodromal symptoms. The most common co-factors were humid-warm weather, severe @entity7 and eating certain foods shortly before the exercise. Prophylactic measures were quite different between individuals. CONCLUSION: Providing detailed information on how to avoid possible cofactors and manage prodromal symptoms should be at the forefront of looking after such @entity0 , most of whom lead a rather active life.

title: [Exercise-induced XXXX and @entity5 ].

answer: @entity1


abstract: AIM: The study was designed to characterise more exactly the complex syndrome of exercise-induced @entity1 and @entity5 in order to obtain guidelines for their management. METHODS: 30 @entity0 (18 @entity0 and 12 @entity0 with physical exercise-induced @entity1 and @entity5 were investigated by questionnaire. The following items were of particular interest: age and sex; age at first manifestation; type, duration and intensity of the precipitating activity; type, duration and sequence of symptoms; prophylactic or therapeutic measures as cofactors. RESULTS: Initial symptoms occurred at an average age of 22 (7-50) years. Atopy was present in 70%. Jogging (60%), ball games (40%) and walking (27%) were the most frequent precipitating activities. On each occasion symptoms began a few minutes to hours after the start of the exercise. During a typical episode an average of eight symptoms were observed, most frequently affecting the skin ( @entity2 , angiooedema, @entity6 and @entity1 ), dyspnoea and @entity3 . @entity4 occurred in nine @entity0 : before they lost consciousness they noted at least two prodromal symptoms. The most common co-factors were humid-warm weather, severe @entity7 and eating certain foods shortly before the exercise. Prophylactic measures were quite different between individuals. CONCLUSION: Providing detailed information on how to avoid possible cofactors and manage prodromal symptoms should be at the forefront of looking after such @entity0 , most of whom lead a rather active life.

title: [Exercise-induced @entity1 and XXXX ].

answer: @entity5


abstract: BACKGROUND: Molecular genetics are a fundamental turning point in the approach to @entity2 of adults ( @entity6 ). DNA analysis makes diagnosis possible at in any ontogenic period, i.e. also during the prenatal period. The objective of the present study was to test the presymptomatic DNA diagnosis in a major group of @entity0 with @entity6 and the possibility to detect the disease in the initial stage and influence its development by early treatment and advise the @entity0 on parenthood. METHODS AND RESULTS: In 1990-1994 the authors contacted 157 @entity0 with @entity1 , @entity3 ( @entity6 ). 87 families were examined by Southern's RFLP method (gene @entity4 , 16p13.3, standard probe 3'HVR and restrictase Pvu II). Of 493 members of these families only 25 (5.1%) refused to be examined. So far 378 examinations were completed, 90 proceed. In 40 of 132 examined subjects with the risk of @entity6 transmission of the gene was proved. Of four examinations of the foetus with the risk of @entity6 twice transmission of the gene was proved and the pregnancy was terminated. In three families with three or more members suffering from @entity6 in some there was not agreement between the result of linkage analysis of DNA and the clinical finding. The authors analyzed whether the cause is recombination or ADKPD conditioned by mutation of gene @entity5 (4p13-23). Linkage analysis remains in @entity6 the basic examination as the sequence of gene @entity4 is not yet completed. Discovery of gene @entity5 the mutations of which condition as many as 15% of all cases of @entity6 has an impact on the evaluation of linkage analysis. The reliability of prediction rises with the number of examined subjects in the family. The examination revealed that @entity0 are willing to have DNA examinations (as many as 98%); despite this the number of examined subjects is only a small fraction of the anticipated 10,000 @entity0 in the Czech Republic suffering from @entity6 : CONCLUSIONS: DNA analysis in @entity0 with @entity1 is the most important examination for its diagnosis. It makes the diagnosis possible in all stages of ontogenesis, incl. prenatal diagnosis. It is a highly valid parameter when these @entity0 decide on parenthood. It makes early treatment possible which can influence the development of the disease and its complications.

title: [Autosomal dominant XXXX ].

answer: @entity1


abstract: BACKGROUND: Up to the present time radical microsurgery of the @entity2 was considered the most satisfactory treatment. Now an ever more important part in the treatment of these @entity2 is played by radiosurgery. It involves minimal surgical stress, a minimal rate of complications and minimal change of lifestyle during the postoperative period. The objective of the submitted work was to evaluate the authors' results with the use of Leksell's gamma knife. METHODS AND RESULTS: In 1992-1994 48 @entity0 with @entity4 were indicated for treatment with a gamma knife. The group comprised 12 @entity0 (25%) and 36 @entity0 (75%) aged 18-73 years (mean age 52.8 years which did not differ significantly in the two groups). In 19 @entity0 (39.6%) one or more neurosurgical operations were carried out previously, in 4 @entity0 (8.3%) fractionated radiotherapy. Karnofski's score, as an indicator of the general condition, varied between 30-90%, the mean value for the whole group being 71%. The calculated volume of the @entity4 was between 0.7 and 25.8 cm3, the average being 7.4 cm3. @entity1 in the adjacent area of the @entity2 was found in 6 @entity0 (12.5%). In 19 @entity0 (39.6%) the @entity2 was at the base of the skull, in 29 @entity0 (60.4%) at other sites. The radiosurgically administered dose was within the range of 6.5-24 Gy, on average 14,2 Gy, on the isodose on average 50.7% (range 40-75%). The dose below the maximum was within the range of 13-45 Gy), on average 28.3 Gy. Only in two @entity0 fractionated administration of the dose was used. After a 6-month interval following operation 30 @entity0 were examined. In 7 @entity0 (23.3%) partial wrinkling of the @entity4 occurred (range 6-18 months), Karnofski's score improved by 10% in 8 (26.6%) and deteriorated in 3 @entity0 (10%). The neurodeficit improved in 7 (23.3%) and deteriorated in 4 @entity0 (13.3%). @entity1 developed in 5 @entity0 (16.6%) 5-7 months after operation, in about half the @entity0 it was symptom free. During the follow up period 2 @entity0 died (8 and 5 months following surgery): in one the cause of @entity3 was not associated with the basic disease, in the second @entity0 (where radiotherapy was the third neurosurgical operation) the radiosurgical operation could not reverse tha fatal course of the disease. CONCLUSIONS: Radiosurgery of @entity4 is a safe therapeutic method with zero mortality, minimal surgical stress, a minimal rate of complications and a minimal morbidity. It is indicated in @entity4 and possibly their residues after subtotal neurosurgery up to a maximal volume of 30 cm3. It is primary treatment suitable in particular in old. @entity0 , @entity0 with a high per- and postoperative risk and in @entity0 refusing open neurosurgery.

title: [Radiosurgical treatment of XXXX with the Leksell gamma knife].

answer: @entity4


abstract: Paroxysmal sensorimotor phenomena of spinal cord origin are well documented in the literature dealing with @entity1 , but have seldom been identified in other conditions. These @entity3 are characterized by tonic @entity7 in the extremities, often accompanied by @entity2 , and are fleeting, usually lasting no more than two minutes. Although they may occur spontaneously, they are commonly precipitated by tactile stimulation or movement of the extremity. These episodes must be clinically differentiated from @entity4 as they have been shown to be responsive to anticonvulsants such as @entity6 ( @entity6 ). We present two @entity0 admitted to our rehabilitation facility with a diagnosis of @entity8 . Clinical and diagnostic evaluation revealed no evidence of @entity1 and follow-up studies for two and one-half years in case 1 and one year in case 2 continued to support the admitting diagnoses. Each @entity0 developed focal sensorimotor phenomena relatively early in the course of the disease which interfered with rehabilitation. Effective treatment was obtained with administration of @entity6 . Subsequently, both @entity0 developed signs and symptoms of @entity1 . The complication of @entity3 may become a limiting factor in the rehabilitation of @entity0 with @entity8 is recognized and appropriate anticonvulsant therapy initiated. It may also be the first indicator that @entity1 rather than "idiopathic" transverse @entity5 is present.

title: XXXX in transverse @entity5 : report of two cases.

answer: @entity3


abstract: Paroxysmal sensorimotor phenomena of spinal cord origin are well documented in the literature dealing with @entity1 , but have seldom been identified in other conditions. These @entity3 are characterized by tonic @entity7 in the extremities, often accompanied by @entity2 , and are fleeting, usually lasting no more than two minutes. Although they may occur spontaneously, they are commonly precipitated by tactile stimulation or movement of the extremity. These episodes must be clinically differentiated from @entity4 as they have been shown to be responsive to anticonvulsants such as @entity6 ( @entity6 ). We present two @entity0 admitted to our rehabilitation facility with a diagnosis of @entity8 . Clinical and diagnostic evaluation revealed no evidence of @entity1 and follow-up studies for two and one-half years in case 1 and one year in case 2 continued to support the admitting diagnoses. Each @entity0 developed focal sensorimotor phenomena relatively early in the course of the disease which interfered with rehabilitation. Effective treatment was obtained with administration of @entity6 . Subsequently, both @entity0 developed signs and symptoms of @entity1 . The complication of @entity3 may become a limiting factor in the rehabilitation of @entity0 with @entity8 is recognized and appropriate anticonvulsant therapy initiated. It may also be the first indicator that @entity1 rather than "idiopathic" transverse @entity5 is present.

title: @entity3 in transverse XXXX : report of two cases.

answer: @entity5


abstract: OBJECTIVE: @entity4 replacement in adults may be considered beneficial by clinicians, but @entity0 may not perceive any benefits. The purpose of this study was to determine whether there were any factors which influenced whether an adult wished to continue on long-term GH replacement after taking part in a study of GH replacement. DESIGN: A 12-month study (double-blind placebo controlled for the first 6 months and open for the second 6 months) of GH replacement (0.125 IU/kg/week for the first month and 0.25 IU/kg/week thereafter) in adults. @entity0 : Sixty-three adults (27 @entity0 , 36 @entity0 , aged 34.9 +/- 1.4 (mean +/- SE, range 20.1-59.5) years) with @entity6 (peak serum GH response to provocative testing less than 10 mU/l) who entered a 12-month study of GH replacement. Thirty @entity0 (48%) wished to continue on GH replacement and 33 @entity0 (52%) did not wish to continue on GH replacement after the study. MEASUREMENTS: Biochemical, anthropometric and demographic characteristics, and well-being, were compared in those @entity0 who wished to continue on long-term GH replacement and in those who did not. In the two groups of @entity0 the age, height, weight, body mass index, serum @entity3 , @entity5 and @entity3 age matched standard deviation score ( @entity2 ) were compared at entry into the study, and changes in @entity3 , @entity5 and @entity3 SDS were compared after 6 months of GH replacement. The @entity0 were compared according to pretreatment peak serum GH response to provocative testing, sex, estimated duration of @entity6 , whether @entity6 was of childhood or adult onset, presence or absence of additional @entity7 , underlying @entity1 , previous therapeutic interventions, employment status, marital status and living arrangement, and according to development of side-effects of GH replacement and the requirement for reduction in dose of GH because of side-effects during the study. Scores on two questionnaire measures of well-being or distress, the Nottingham Health Profile (NHP) and the Psychological General Well-Being Schedule (PGWBS), were compared at entry into the study in the two groups, as were change in scores on these questionnaires after 6 months of GH replacement. RESULTS: Those who continued on GH replacement tended to have a greater severity of @entity6 (median peak serum GH concentration 0.7 vs 2.3 mU/l, P = 0.06), tended to have greater distress in terms of energy (NHP, P = 0.06) and vitality (PGWBS, P = 0.06) at entry into the study and showed an improvement in energy during the study compared with no change in those who did not wish to continue on GH replacement (NHP, P = 0.06). CONCLUSION: Those adults who wished to continue on GH replacement tended to have a greater severity of @entity6 , to experience more distress in terms of energy and vitality at entry into the study and to experience an improvement in energy after 6 months treatment with GH.

title: Factors influencing the desire for long-term XXXX replacement in adults.

answer: @entity4


abstract: We studied prospectively 154 febrile @entity0 to determine the diagnostic value of the quantitative serum @entity5 concentrations ( @entity5 ). @entity0 with @entity3 , @entity3 , or treated with antibiotics during the two previous weeks and @entity0 less than 2 months of age were excluded. Ninety seven @entity0 were from private paediatric practice and 57 were @entity0 who had been admitted to hospital. The comparison group consisted of 75 @entity0 with confirmed @entity6 whose @entity5 values were recorded retrospectively. In the study group 35 (23%) @entity0 had a confirmed @entity4 , 92 (59%) had a probable @entity4 as judged from the clinical picture and outcome of the illness, and 27 (18%) had a bacterial or probable @entity6 . When the duration of the disease was more than 12 hours and the @entity5 value less than 20 mg/l, all @entity0 had a confirmed or probable @entity4 . Nine @entity0 (one from the study group and eight from the comparison group) were found to have a @entity1 and a @entity5 value of 20 mg/l or less. In all these cases, however, the duration of the symptoms was less than 12 hours. In addition @entity5 less than or equal to 20 mg/l was found in five (14%) @entity0 with @entity2 in the comparison group. @entity5 values of 20-40 mg/l were recorded in @entity0 with both viral and @entity6 . A @entity5 value greater than or equal to 40 mg/l detected 79% of @entity6 with 90% specificity. Our data show that determination of serum @entity5 concentrations is a valuable tool in evaluating @entity0 who have been ill for more than 12 hours.

title: XXXX in the evaluation of febrile illness.

answer: @entity5


abstract: Mitral valve repair has been increasingly used at our hospital for @entity3 with and without @entity2 . From January, 1984, to June, 1987, of 338 @entity0 undergoing all forms of mitral valve surgery, 140 had first-time surgery for pure @entity3 : 75 had valve repair, and 65 had valve replacement. Thirty-three of 75 (44%) had concomitant coronary bypass in the repair group, while 21 of 65 (32%) had coronary bypass in the replacement group. The mean functional class (3.4 versus 3.5), age (60 versus 61 years), and preoperative hemodynamics were similar in both groups. The cause of @entity3 in the repair group was myxomatous change in 32 @entity0 , @entity1 in 27, @entity4 in 12, and @entity5 in 4. A Carpentier ring was used in 46, a Duran ring was used in 11, and none was used in 18. The operative mortality was 3 of 75 @entity0 (4%) in the repair group, all with coronary artery bypass grafting, versus 2 of 65 @entity0 (3%) in the replacement group, 1 of whom had undergone coronary artery bypass grafting. The mean postoperative functional class 15 months postoperatively was 1.12 in the repair group versus 1.15 in the replacement group. There were 7 late deaths in the replacement group and only 3 late deaths in the repair group. Actuarial survival at 30 months was 85 +/- 6% for the replacement group and 94 +/- 4% for the repair group. There were 5 late emboli (1 fatal, 4 nonfatal) after valve replacement and none after valve repair (p = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Comparative morbidity of mitral valve repair versus replacement for XXXX with and without coronary artery disease.

answer: @entity3


abstract: UNASSIGNED: @entity2 ( @entity2 ) is an escalating challenge to individuals and the welfare state, with mental health problems as imminent hazard. The objective of the present paper was to determine if a diagnosis of @entity1 increased the risk of subsequent @entity2 , and whether the risk differed by gender. A population cohort of 1230 @entity0 were diagnostically interviewed (Composite International Diagnostic Interview, CIDI) in a population study examining mental health, linked to the @entity2 registry and followed for 10  years. The risk for @entity2 following @entity1 was estimated using Cox regression. Life-time @entity1 , as well as current @entity1 , increased the risk of subsequent @entity2 for both genders. The fully adjusted [baseline health, health behavior and socio-economic status (SES)] hazard ratios (HRs) for life-time depressed @entity0 and @entity0 were 2.9 [95% confidence interval (CI) 1.5-5.8] and 1.6 (95% CI 1.0-2.5) respectively. @entity0 were significantly older at time of @entity2 . There are reasons to believe that @entity1 went under-recognized and under-treated. To augment knowledge in the field, without underestimating @entity1 as risk for @entity2 , a deeper understanding of the nature and effects of other distress is needed. Copyright    2015 John Wiley _ Sons, Ltd.

title: Predicting disability pension - XXXX as hazard: a 10  year population-based cohort study in norway.

answer: @entity1


abstract: BACKGROUND: Due to the increasing evidence of their health benefits, whole grains are recommended for consumption worldwide. Such recommendations are, however, rarely quantitative. Our aim was to perform a quantitative evaluation of the relationship between whole grain consumption and the occurrence of @entity1 ( @entity1 ) to support a recommendation on the daily consumption of whole grains. METHODS AND FINDINGS: We conducted a systematic review by searching three bibliographic databases. We included @entity0 studies addressing the relationship between whole grain consumption and @entity1 occurrence, and providing quantitative information on daily intake of whole grains. A dose-response meta-regression analysis between whole grain intake and @entity1 occurrence was performed, using a hierarchical mixed least square linear regression model. Eight observational studies were included (all but one prospective), with a total of 15,573 cases of @entity1 among 316,051 @entity0 . Quantitative meta-regression demonstrated a significant linear inverse relationship between whole grain intake and @entity1 occurrence (P<0.0001), with an overall absolute reduction of 0.3% in the @entity1 rate for each additional 10 g of whole grain ingredient consumed daily. The association persisted when adjusted on sex, age, country, study design, follow up duration, and mode of report of whole grain intakes (as foods or ingredients). CONCLUSIONS: The meta-regression model made it possible to estimate the decrease in @entity1 risk corresponding to various changes in whole grain intakes, and the results contribute to setting up quantitative recommendations. For instance, consuming three servings of whole grain foods (45 g of whole grain ingredients) daily would induce a 20% relative reduction in the @entity1 risk as compared to consuming a half serving (7.5 g of whole grain ingredients). These results should be considered for future recommendations, by considering the actual whole grain intake of the concerned populations. The systematic review protocol was published on the PROSPERO register (CRD42013006925).

title: Systematic Review and Meta-Analysis of XXXX Studies to Support a Quantitative Recommendation for Whole Grain Intake in Relation to Type 2 Diabetes.

answer: @entity0


abstract: 1. The @entity0 heart develops a @entity3 after @entity4 which is secondary to @entity5 in the left ventricle (LV) and to pressure overload in the right ventricle (RV). This study was undertaken to determine whether the reduced inotropic response to @entity1 presented by the LV of infarcted @entity0 extends to the RV and whether this hemodynamic profile in vivo affects the contractile performance of the ventricles assessed in vitro. 2. Male adult @entity0 were submitted to left coronary artery ligation to produce @entity4 ( @entity4 ) or to a sham surgery (SO) and used 4 to 5 weeks later. The hemodynamic data were recorded in the anesthetized animals and the systolic performance of both ventricles was evaluated in vitro in the hearts perfused by the Langendorff technique. The isovolumic systolic pressure (ISP) developed by both ventricles was measured at various diastolic pressures (0 to 30 mmHg) and @entity1 concentrations (0.62, 1.25, and 2.50 mM). 3. The RV systolic pressure was higher in @entity4 (N = 12) than in SO (N = 12) @entity0 (42 +/- 5 vs 26 +/- 1 mmHg, P < 0.05). A positive and linear correlation (r = 0.86, P < 0.01) between RV systolic pressure and the RV weight to body weight ratio in @entity4 @entity0 was observed. 4. Length-dependent activation, evaluated by using normalized ventricular function curves, was unchanged in the RV of @entity4 hearts. In the @entity4 LV, however, a slight improvement of the normalized systolic performance was observed in relation to SO hearts for diastolic pressures higher than 15 mmHg. 5. A similar @entity2 of the inotropic response to @entity1 was observed in both ventricles of @entity4 hearts. Moreover, for @entity4 hearts the increase of the ISP to @entity1 flattened at lower @entity1 concentrations in relation to the SO group. 6. The present results demonstrate that LV @entity4 in @entity0 depresses the contractile performance of both ventricles. The reduced inotropic response to @entity1 presented by both ventricles may contribute to the reduced capacity of the @entity4 heart to generate external work under conditions of higher metabolic demand.

title: Analysis of right and left ventricular performance of the XXXX heart with chronic myocardial infarction.

answer: @entity0


abstract: UNASSIGNED: Microorganisms responsible for the degradation of @entity2 in a clean forest soil sample were identified by DNA-based stable isotope probing (SIP). The soil was artificially amended with either 12C- or @entity1 -labeled @entity2 , and soil DNA was extracted on days 3, 6 and 9. Terminal restriction fragment length polymorphism (TRFLP) results revealed that the fragments of 219- and 241-bp in HaeIII digests were distributed throughout the gradient profile at three different sampling time points, and both fragments were more dominant in the heavy fractions of the samples exposed to the @entity1 -labeled contaminant. 16S rRNA sequencing of the @entity1 -enriched fraction suggested that Acidobacterium spp. within the class Acidobacteria, and Collimonas spp. within the class Betaproteobacteria, were directly involved in the uptake and degradation of @entity2 at different times. To our knowledge, this is the first report that the genus Collimonas has the ability to degrade @entity0 . Two PAH-RHDa genes were identified in @entity1 -labeled DNA. However, isolation of pure cultures indicated that strains of Staphylococcus sp. @entity3 , Pseudomonas sp. PHE-1, and Pseudomonas sp. PHE-2 in the soil had high @entity2 -degrading ability. This emphasizes the role of a culture-independent method in the functional understanding of microbial communities in situ.

title: Novel XXXX -Degrading Bacteria Identified by DNA-Stable Isotope Probing.

answer: @entity2