abstract: OBJECTIVE: In animal experiments many hormones were demonstrated in immune cells. However, very few data are at our disposal in the case of @entity0 immune cells. In an earlier experiment, @entity7 , endorphin and T(3) were studied and found in different subsets of @entity0 immune cells. Here, three biogenic @entity6 ( @entity2 , @entity3 and @entity5 ) were studied. METHODS: Biogenic @entity8 content of immunophenotyped @entity0 lymphocytes from 15 blood donors were investigated by multicolor flow cytometry using anti-biogenic @entity8 antibodies. Monocytes and granulocytes separated by size and granularity were also studied. RESULTS: Each biogenic @entity8 could be detected in each subset of leukocytes, except @entity5 and @entity3 in granulocytes. Activated T cells contained a higher amount of the @entity6 , and @entity4 +B cells a higher amount of @entity2 , related to the whole lymphocyte population and to other subsets. Monocytes contained more @entity2 and @entity5 than lymphocytes and granulocytes contained twice as much @entity2 as monocytes and three times as much as lymphocytes. CONCLUSION: @entity0 lymphocytes contain the three biogenic @entity8 , similar to @entity1 . However, while each @entity8 was present in monocytes, in granulocytes @entity3 and @entity5 were not demonstrated. The results call attention to the possible extrapolation of animal data to @entity0 lymphocytes and monocytes, but in the case of granulocytes, caution is needed. Taking into consideration earlier results, activated T cells appear to have an important role in the loss or production of hormones inside the immune system.

title: Presence and distribution of biogenic XXXX ( @entity2 , @entity3 and @entity5 ) in immunophenotyped @entity0 immune cells.

answer: @entity6


abstract: OBJECTIVE: In animal experiments many hormones were demonstrated in immune cells. However, very few data are at our disposal in the case of @entity0 immune cells. In an earlier experiment, @entity7 , endorphin and T(3) were studied and found in different subsets of @entity0 immune cells. Here, three biogenic @entity6 ( @entity2 , @entity3 and @entity5 ) were studied. METHODS: Biogenic @entity8 content of immunophenotyped @entity0 lymphocytes from 15 blood donors were investigated by multicolor flow cytometry using anti-biogenic @entity8 antibodies. Monocytes and granulocytes separated by size and granularity were also studied. RESULTS: Each biogenic @entity8 could be detected in each subset of leukocytes, except @entity5 and @entity3 in granulocytes. Activated T cells contained a higher amount of the @entity6 , and @entity4 +B cells a higher amount of @entity2 , related to the whole lymphocyte population and to other subsets. Monocytes contained more @entity2 and @entity5 than lymphocytes and granulocytes contained twice as much @entity2 as monocytes and three times as much as lymphocytes. CONCLUSION: @entity0 lymphocytes contain the three biogenic @entity8 , similar to @entity1 . However, while each @entity8 was present in monocytes, in granulocytes @entity3 and @entity5 were not demonstrated. The results call attention to the possible extrapolation of animal data to @entity0 lymphocytes and monocytes, but in the case of granulocytes, caution is needed. Taking into consideration earlier results, activated T cells appear to have an important role in the loss or production of hormones inside the immune system.

title: Presence and distribution of biogenic @entity6 ( @entity2 , @entity3 and XXXX ) in immunophenotyped @entity0 immune cells.

answer: @entity5


abstract: OBJECTIVE: In animal experiments many hormones were demonstrated in immune cells. However, very few data are at our disposal in the case of @entity0 immune cells. In an earlier experiment, @entity7 , endorphin and T(3) were studied and found in different subsets of @entity0 immune cells. Here, three biogenic @entity6 ( @entity2 , @entity3 and @entity5 ) were studied. METHODS: Biogenic @entity8 content of immunophenotyped @entity0 lymphocytes from 15 blood donors were investigated by multicolor flow cytometry using anti-biogenic @entity8 antibodies. Monocytes and granulocytes separated by size and granularity were also studied. RESULTS: Each biogenic @entity8 could be detected in each subset of leukocytes, except @entity5 and @entity3 in granulocytes. Activated T cells contained a higher amount of the @entity6 , and @entity4 +B cells a higher amount of @entity2 , related to the whole lymphocyte population and to other subsets. Monocytes contained more @entity2 and @entity5 than lymphocytes and granulocytes contained twice as much @entity2 as monocytes and three times as much as lymphocytes. CONCLUSION: @entity0 lymphocytes contain the three biogenic @entity8 , similar to @entity1 . However, while each @entity8 was present in monocytes, in granulocytes @entity3 and @entity5 were not demonstrated. The results call attention to the possible extrapolation of animal data to @entity0 lymphocytes and monocytes, but in the case of granulocytes, caution is needed. Taking into consideration earlier results, activated T cells appear to have an important role in the loss or production of hormones inside the immune system.

title: Presence and distribution of biogenic @entity6 ( @entity2 , XXXX and @entity5 ) in immunophenotyped @entity0 immune cells.

answer: @entity3


abstract: OBJECTIVE: In animal experiments many hormones were demonstrated in immune cells. However, very few data are at our disposal in the case of @entity0 immune cells. In an earlier experiment, @entity7 , endorphin and T(3) were studied and found in different subsets of @entity0 immune cells. Here, three biogenic @entity6 ( @entity2 , @entity3 and @entity5 ) were studied. METHODS: Biogenic @entity8 content of immunophenotyped @entity0 lymphocytes from 15 blood donors were investigated by multicolor flow cytometry using anti-biogenic @entity8 antibodies. Monocytes and granulocytes separated by size and granularity were also studied. RESULTS: Each biogenic @entity8 could be detected in each subset of leukocytes, except @entity5 and @entity3 in granulocytes. Activated T cells contained a higher amount of the @entity6 , and @entity4 +B cells a higher amount of @entity2 , related to the whole lymphocyte population and to other subsets. Monocytes contained more @entity2 and @entity5 than lymphocytes and granulocytes contained twice as much @entity2 as monocytes and three times as much as lymphocytes. CONCLUSION: @entity0 lymphocytes contain the three biogenic @entity8 , similar to @entity1 . However, while each @entity8 was present in monocytes, in granulocytes @entity3 and @entity5 were not demonstrated. The results call attention to the possible extrapolation of animal data to @entity0 lymphocytes and monocytes, but in the case of granulocytes, caution is needed. Taking into consideration earlier results, activated T cells appear to have an important role in the loss or production of hormones inside the immune system.

title: Presence and distribution of biogenic @entity6 ( @entity2 , @entity3 and @entity5 ) in immunophenotyped XXXX immune cells.

answer: @entity0


abstract: We investigated somatic mutations of the @entity4 gene in @entity6 tissue and their detection using real-time polymerase chain reaction with TaqMan-MGB probes. METHODS: The DNA was extracted from surgically resected @entity6 specimens. Genes encoding for @entity4 @entity5 (exons 18, 19, and 21) were amplified by nested polymerase chain reaction, sequenced, and analyzed by chromatograms with manual review. TaqMan-MGB probes were designed to detect the @entity4 gene mutations in the @entity2 tissues using real-time polymerase chain reaction. RESULTS: Somatic point mutations and deletions were identified in the @entity5 kinase domain of the @entity4 gene in 21 of 80 @entity6 @entity0 , including 13 @entity0 with deletion mutations occurring in exon 19 and 8 @entity0 with point mutations occurring in codon 858 (exon 21). The results from real-time polymerase chain reaction with TaqMan-MGB probes were completely consistent with sequencing outcomes. Both the sensitivity and specificity for detecting the @entity4 gene mutations using real-time polymerase chain reaction with TaqMan-MGB probes were 100%. The mutation incidence was significantly higher in female @entity0 , nonsmokers, and @entity0 with @entity3 than in male @entity0 , smokers, and those with nonadenocarcinomas (P < 0.05). The mutations were not related to @entity0 's age or @entity2 nodal @entity1 staging. CONCLUSIONS: Somatic mutations of the @entity4 gene that develop in @entity6 @entity0 are more common in female @entity0 , nonsmokers, and @entity0 with @entity3 . Real-time polymerase chain reaction using TaqMan-MGB probes is effective, simple, and fast in the detection of @entity4 gene mutations.

title: Rapid detection of @entity4 mutations in XXXX using real-time polymerase chain reaction with TaqMan-MGB probes.

answer: @entity6


abstract: We investigated somatic mutations of the @entity4 gene in @entity6 tissue and their detection using real-time polymerase chain reaction with TaqMan-MGB probes. METHODS: The DNA was extracted from surgically resected @entity6 specimens. Genes encoding for @entity4 @entity5 (exons 18, 19, and 21) were amplified by nested polymerase chain reaction, sequenced, and analyzed by chromatograms with manual review. TaqMan-MGB probes were designed to detect the @entity4 gene mutations in the @entity2 tissues using real-time polymerase chain reaction. RESULTS: Somatic point mutations and deletions were identified in the @entity5 kinase domain of the @entity4 gene in 21 of 80 @entity6 @entity0 , including 13 @entity0 with deletion mutations occurring in exon 19 and 8 @entity0 with point mutations occurring in codon 858 (exon 21). The results from real-time polymerase chain reaction with TaqMan-MGB probes were completely consistent with sequencing outcomes. Both the sensitivity and specificity for detecting the @entity4 gene mutations using real-time polymerase chain reaction with TaqMan-MGB probes were 100%. The mutation incidence was significantly higher in female @entity0 , nonsmokers, and @entity0 with @entity3 than in male @entity0 , smokers, and those with nonadenocarcinomas (P < 0.05). The mutations were not related to @entity0 's age or @entity2 nodal @entity1 staging. CONCLUSIONS: Somatic mutations of the @entity4 gene that develop in @entity6 @entity0 are more common in female @entity0 , nonsmokers, and @entity0 with @entity3 . Real-time polymerase chain reaction using TaqMan-MGB probes is effective, simple, and fast in the detection of @entity4 gene mutations.

title: Rapid detection of XXXX mutations in @entity6 using real-time polymerase chain reaction with TaqMan-MGB probes.

answer: @entity4


abstract: BACKGROUND: @entity7 is the principal cause of @entity3 after hepatectomy. Its progression towards @entity3 and its relationship with @entity4 are unclear. This study analysed predictors of mortality in @entity0 with @entity5 and the role of @entity4 in the @entity3 of these @entity0 . METHODS: The study focused on @entity0 with @entity5 , excluding those with vascular @entity6 , after liver resection at one of two centres between 1998 and 2006. RESULTS: @entity5 occurred after 57 (4.5 per cent) of 1271 hepatectomies. Fifty-three @entity0 without vascular @entity6 were included in the analysis, with a mortality rate of 23 per cent. Independent predictors of @entity3 were age (odds ratio (OR) 1.18 per year increase; P = 0.017), @entity1 (OR 54.09; P = 0.004) and @entity2 (OR 37.58; P = 0.005). @entity4 occurred in 15 @entity0 (28 per cent), seven of whom died. Intestinal pathogens were isolated in 12 @entity0 with @entity4 . The risk of @entity4 was significantly increased in those with surgical complications (11 of 16 versus four of 37; P < 0.001). CONCLUSION: @entity4 plays a key role in the @entity3 of @entity0 with @entity5 after hepatectomy. Early recognition and aggressive treatment of @entity4 may reduce mortality.

title: @entity5 and XXXX determine operative mortality after liver resection.

answer: @entity4


abstract: BACKGROUND: @entity7 is the principal cause of @entity3 after hepatectomy. Its progression towards @entity3 and its relationship with @entity4 are unclear. This study analysed predictors of mortality in @entity0 with @entity5 and the role of @entity4 in the @entity3 of these @entity0 . METHODS: The study focused on @entity0 with @entity5 , excluding those with vascular @entity6 , after liver resection at one of two centres between 1998 and 2006. RESULTS: @entity5 occurred after 57 (4.5 per cent) of 1271 hepatectomies. Fifty-three @entity0 without vascular @entity6 were included in the analysis, with a mortality rate of 23 per cent. Independent predictors of @entity3 were age (odds ratio (OR) 1.18 per year increase; P = 0.017), @entity1 (OR 54.09; P = 0.004) and @entity2 (OR 37.58; P = 0.005). @entity4 occurred in 15 @entity0 (28 per cent), seven of whom died. Intestinal pathogens were isolated in 12 @entity0 with @entity4 . The risk of @entity4 was significantly increased in those with surgical complications (11 of 16 versus four of 37; P < 0.001). CONCLUSION: @entity4 plays a key role in the @entity3 of @entity0 with @entity5 after hepatectomy. Early recognition and aggressive treatment of @entity4 may reduce mortality.

title: XXXX and @entity4 determine operative mortality after liver resection.

answer: @entity5


abstract: BACKGROUND _ OBJECTIVE: Reactive @entity5 following chemotherapy for @entity1 is likely to be misdiagnosed as @entity1 residue or relapse, therefore, leads to unnecessary treatment. This study was to analyze the clinical features of reactive @entity5 following chemotherapy for childhood @entity2 . METHODS: Clinical data of 13 @entity0 with reactive @entity5 following chemotherapy for @entity2 , treated from Mar. 1999 to Mar. 2004, were retrospectively analyzed. Of the 13 cases, 5 were @entity3 ( @entity3 ), and 8 were @entity4 ( @entity4 ). All @entity0 received computed tomography (CT) to evaluate the therapeutic effect. When a new thymic mass emerged, positive electron tomography/computed tomography (PET/CT) was performed to identify its quality. RESULTS: At diagnosis, 10 @entity0 had mediastinal involvement. Reactive @entity5 occurred following the completion of chemotherapy in 9 cases, or during the maintenance of chemotherapy in 4 cases. CT showed that the longest diameters of the new mediastinal masses were 2.2-6.0 cm (mean 3.7 cm). The interval from last chemotherapy cycle to the occurrence of @entity5 was 2-12 months (mean 4 months). PET/CT was performed to 5 cases, and showed no vital @entity1 in the mediastinum. Three cases were misdiagnosed as @entity1 residue or relapse, and received second-line therapy. All @entity0 were followed-up for 1-6 years (median 4 years), and none @entity1 relapse. CONCLUSIONS: Reactive @entity5 may occur following intensive chemotherapy for childhood @entity2 . It should not be misdiagnosed as @entity1 and overtreated.

title: [Clinical analysis of reactive XXXX following chemotherapy for childhood @entity2 ].

answer: @entity5


abstract: BACKGROUND _ OBJECTIVE: Reactive @entity5 following chemotherapy for @entity1 is likely to be misdiagnosed as @entity1 residue or relapse, therefore, leads to unnecessary treatment. This study was to analyze the clinical features of reactive @entity5 following chemotherapy for childhood @entity2 . METHODS: Clinical data of 13 @entity0 with reactive @entity5 following chemotherapy for @entity2 , treated from Mar. 1999 to Mar. 2004, were retrospectively analyzed. Of the 13 cases, 5 were @entity3 ( @entity3 ), and 8 were @entity4 ( @entity4 ). All @entity0 received computed tomography (CT) to evaluate the therapeutic effect. When a new thymic mass emerged, positive electron tomography/computed tomography (PET/CT) was performed to identify its quality. RESULTS: At diagnosis, 10 @entity0 had mediastinal involvement. Reactive @entity5 occurred following the completion of chemotherapy in 9 cases, or during the maintenance of chemotherapy in 4 cases. CT showed that the longest diameters of the new mediastinal masses were 2.2-6.0 cm (mean 3.7 cm). The interval from last chemotherapy cycle to the occurrence of @entity5 was 2-12 months (mean 4 months). PET/CT was performed to 5 cases, and showed no vital @entity1 in the mediastinum. Three cases were misdiagnosed as @entity1 residue or relapse, and received second-line therapy. All @entity0 were followed-up for 1-6 years (median 4 years), and none @entity1 relapse. CONCLUSIONS: Reactive @entity5 may occur following intensive chemotherapy for childhood @entity2 . It should not be misdiagnosed as @entity1 and overtreated.

title: [Clinical analysis of reactive @entity5 following chemotherapy for childhood XXXX ].

answer: @entity2


abstract: Our objective was to estimate the effect of Mycobacterium @entity0 on milk, fat, and protein yield deviations, pregnancy rate, lactation somatic cell score, and projected total months in milk (productive life). A serum ELISA and fecal culture for M. @entity2 were performed on 4375 Holsteins in 232 DHIA herds throughout the US. Primarily first through third lactation @entity1 (99% of total) were assayed for @entity0 . Trait information (except productive life) was obtained for the lactation concurrent with disease tests. Productive life was total months in milk through a @entity1 's life, which was projected if a @entity1 was still milking. For most analyses, case definition for M. @entity0 was defined as either an ELISA S/P ratio>or=0.25 or a positive fecal culture for M. @entity2 or both. To determine if diagnostic test affected estimates, case definition was redefined to include only @entity1 with ELISA S/P ratios>or=0.25 or only fecal culture-positive @entity1 . Linear models were used to estimate effect of M. @entity0 on traits. M. @entity0 @entity1 (7.89% of @entity1 ) produced 303.9 kg less milk/lactation, 11.46 kg less fat/lactation, and 9.49 kg less protein/lactation (P<or=0.003). Infected @entity1 had higher pregnancy rates (1.39%) (P=0.0385) and lower productive life (2.85 months) (P<or=0.0001). M. @entity0 did not affect somatic cell score. Effect of @entity0 on milk and protein yields was larger in first lactation M. @entity2 -positive @entity1 relative to @entity1 that tested positive in later lactations. Fecal culture-positive @entity1 had consistently larger effects on all traits than ELISA-positive @entity1 . M. @entity0 , and not just clinical @entity2 , decreases milk, fat, and protein yields, thus increasing the estimated cost of @entity2 to the US dairy industry.

title: Effect of Mycobacterium XXXX on production, reproduction, and health traits in US Holsteins.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVE: Several studies have Shown the correlation of high numbers of @entity1 -infiltrating natural killer (NK) cells with a good prognosis for @entity1 @entity0 . This study was to investigate the impact of NK cell infiltration on the survival and prognosis of @entity0 with @entity2 ( @entity2 ) after resection. METHODS: The proportion of infiltrating NK cells of @entity2 @entity0 was measured using flow cytometry, and the expression of @entity3 + (NK) cells was investigated using immunohistochemistry. Prognostic values of intratumoral and peritumoral NK cell densities were evaluated by Kaplan-Meier method and Cox regression. RESULTS: The level of NK cells was significantly lower in @entity1 -infiltrating lymphocytes (TIL) of @entity2 @entity0 than in nontumor-infiltrating lymphocytes (NIL) [(11.8 +/- 8.1)% vs. (18.0+/-7.9)%, P=0.002]. The density of NK cells was also significantly lower in @entity1 nests than in peritumoral lesions (2.3 +/- 2.6 vs. 8.5 +/- 4.5 cells per field, P<0.001). @entity0 with low intratumoral NK cells had shorter disease-free survival (P=0.027) and overall survival (P=0.005) than @entity0 with high intratumoral NK cells. In contrast, NK cells in the peritumoral area showed no prognostic significance for either disease-free survival or overall survival. Multivariate Cox proportional hazards analysis showed that intratumoral NK cell density was an independent prognostic factor of prolonged overall survival (hazard ratio = 2.658, P=0.019). CONCLUSION: Low NK cells infiltration could predict poor prognosis in @entity0 with @entity2 .

title: [Prognostic significance of natural killer cell infiltration in XXXX ].

answer: @entity2


abstract: OBJECTIVE: This study tested whether @entity1 , a continuity of care intervention for substance-use disorders, improved employment among @entity0 and @entity0 on public assistance compared with usual welfare management. METHOD: @entity0 were 421 welfare applicants identified via substance-use-disorder screening and assigned via a computerized allocation program to @entity1 ( @entity1 ; n = 232) or referral and monitoring practices in usual care (UC; n = 189). Substance use, treatment attendance, job training and search activities, and employment outcomes were assessed for 1 year after baseline. RESULTS: @entity0 were more likely to be working than @entity0 overall. Among @entity0 , @entity1 clients increased their employment over time, whereas UC clients remained stable at very low employment levels. There were no treatment effects on employment for @entity0 . Also among @entity0 only, greater substance-use-disorder treatment attendance and abstinence in the first 6 months of @entity1 predicted higher rates of later employment. Job training activities were low and did not differ by condition between either gender. CONCLUSIONS: Findings are consistent with previous research supporting the effectiveness of case management for improving abstinence, which leads to employment gains, among substance-using @entity0 on public assistance. In contrast, various mandated elements of welfare-to-work programs for substance users-treatment attendance, case management, job training-did not improve employment rates for @entity0 . Implications of study results for designing effective welfare-to-work interventions in a post-welfare-reform era are discussed.

title: Does XXXX improve employment for substance-using welfare recipients?

answer: @entity1


abstract: The arterial baroreflex is a fundamental reflex that buffers rapid changes in arterial blood pressure (BP) via regulation of the heart rate and sympathetic nerve activity to the vasculature. In adults a sigmoidal relationship between BP and both heart rate and sympathetic nerve activity is well documented. Its role in blood pressure control before birth is unclear. Preterm babies have a high incidence of low BP, especially in the first few days of life, which could be related, in part, to immaturity of the baroreflex. In the present study, we investigated the baroreflex control of fetal heart rate and renal sympathetic nerve activity (RSNA) in preterm fetal @entity2 in utero (102 +/- 1 days of gestation; term 140 days). @entity4 was associated with a significant increase in BP from 38 +/- 2 to 58 +/- 3 mmHg and a decrease in heart rate (HR) from 177 +/- 4 to 116 +/- 8 beats per minute (bpm). @entity3 was associated with a significant fall in BP from 38 +/- 2 to 26 +/- 1 mmHg and an increase in HR from 182 +/- 4 to 274 +/- 8 bpm. However, the time between the 50% changes in BP and HR was significantly greater after @entity1 than @entity0 (31 +/- 8 s vs. 14 +/- 5 s, P < 0.05). No significant changes in RSNA occurred with either stimulus. This suggests that there are different maturational tempos for the components of the central autonomic response to altered blood pressure.

title: Is baroreflex control of sympathetic activity and heart rate active in the preterm fetal XXXX ?

answer: @entity2


abstract: OBJECTIVES: To compare a laparoscopic (totally extraperitoneal patch (TEP)) and an open technique (Lichtenstein) for @entity1 regarding recurrence rate and possible risk factors for recurrence. SUMMARY BACKGROUND DATA: Laparoscopic hernia repair has been introduced as an alternative to open repair. Short-term follow-up suggests benefits for those @entity0 operated with a laparoscopic approach compared with open techniques; ie, less @entity2 and a shorter convalescence period. Long-term results, however, are less well known. METHODS: The study was conducted as a multicenter randomized trial with a 5-year follow-up. A total of 1512 @entity0 aged 30 to 70 years, with a primary @entity1 , were randomized to either TEP or Lichtenstein repair. RESULTS: Overall, 665 @entity0 in the TEP group and 705 @entity0 in the Lichtenstein group were evaluable. The cumulative recurrence rate was 3.5% in the TEP group and 1.2% in the Lichtenstein group (P = 0.008). Test for heterogeneity revealed significant differences between individual surgeons. The exclusion of 1 surgeon, who was responsible for 33% (7 of 21) of all recurrences in the TEP group, lowered the cumulative recurrence rate to 2.4% in this group, which was not statistically different from that of the Lichtenstein group. CONCLUSIONS: The recurrence rate for both @entity3 and Lichtenstein repair was low. A higher cumulative recurrence rate in the TEP group was seen at 5 years. Further analysis revealed that this could be attributable to incorrect surgical technique.

title: Low recurrence rate after laparoscopic (TEP) and open (Lichtenstein) XXXX : a randomized, multicenter trial with 5-year follow-up.

answer: @entity1


abstract: BACKGROUND: No randomized controlled trial has compared laparoscopic sigmoid resection (LSR) to open sigmoid resection (OSR) for symptomatic @entity5 of the sigmoid colon. This study tested the hypothesis that LSR is associated with @entity3 rates as compared with OSR. METHODS: This was a prospective, multicenter, double-blind, parallel-arm, randomized controlled trial. Eligible @entity0 were randomized to either LSR or OSR. Endpoints included postoperative mortality, and complications were classified as major and minor. The generator of the allocation sequence was separated from the executor. Blinding was ensured using an opaque wound dressing to cover the abdomen. Symptomatic @entity5 of the sigmoid colon was defined as recurrent disease Hinchey I, IIa, IIb, symptomatic stricture, or severe @entity4 . The decision to discharge @entity0 was made by independent physicians blind to the allocation sequence. Data were analyzed according to the intention to treat principle. RESULTS: From 2002 to 2006, 104 @entity0 were randomized in 5 centers. All @entity0 underwent the allocated intervention. Fifty-two LSR @entity0 were comparable to 52 OSR @entity0 for gender, age, BMI, ASA grade, comorbid conditions, previous abdominal surgery, and indication for surgery. LSR took longer (P = 0.0001) but caused less @entity2 (P = 0.033). Conversion rate was 19.2%. Mortality rate was 1%. There were significantly more major complications in OSR @entity0 (9.6% vs. 25.0%; P = 0.038). Minor complication rates were similar (LSR 36.5% vs. OSR 38.5%; P = 0.839). LSR @entity0 had @entity1 (Visual Analog Scale 1.6; P = 0.0003), systemic analgesia requirement (P = 0.029), and returned home earlier (P = 0.046). The short form-36 questionnaire showed significantly better quality of life for LSR. CONCLUSIONS: LSR was associated with a 15.4% reduction in major complication rates, @entity1 , improved quality of life, and shorter hospitalization at the cost of a longer operating time.

title: Laparoscopic sigmoid resection for XXXX decreases major morbidity rates: a randomized control trial: short-term results of the Sigma Trial.

answer: @entity5


abstract: The safety and effectiveness of the minimum incision technique were assessed in 138 hands of 108 consecutive @entity0 with @entity4 treated from April 1, 1997 to March 31, 2006. Clinical and electrophysiological examinations were conducted before and after surgical decompression. All hands were divided into early, mild, moderate, and severe groups based on preoperative electrophysiological severity. We examined the surgical outcomes of the affected hands in each group. Nocturnal or @entity1 , which had been present in 132 (96%) of the 138 hands preoperatively, was completely relieved in 124 (94%) of the 132 hands. Complete relief was achieved in 7 (100%) of the 7 hands in the early group, 68 (99%) of the 69 hands in the mild group, and 45 (94%) of the 48 hands in the moderate group. Complete relief was achieved only in 4 (50%) of the 8 hands in the severe group, and 3 (38%) of the 8 hands did not show any improvement. No @entity3 or @entity5 was observed in this series. Only 2 @entity0 complained of @entity2 after more than 12 months, which completely disappeared by 14 months after surgery. Minimum incision open carpal tunnel release is a safe and reliable procedure with a high rate of functional improvement and @entity0 satisfaction. Postoperative results were satisfactory regardless of the degree of preoperative electrophysiological severity if preoperative sensory nerve action potentials were detected.

title: XXXX : electrophysiological grading and surgical results by minimum incision open carpal tunnel release.

answer: @entity4


abstract: PURPOSE: The purpose of this study was to identify the intra-articular pathology associated with peroneal @entity4 and report the outcomes after tendon repair or tenodesis with arthroscopic treatment. METHODS: Thirty @entity0 were evaluated who underwent ankle arthroscopy followed by peroneal tendon repair. Intra-articular pathology was treated arthroscopically before peroneal tendon surgery was performed. All @entity0 were available for a minimum 2-year follow-up. Preoperative and postoperative American Orthopaedic Foot _ Ankle Society and Karlsson scores were analyzed for all @entity0 . RESULTS: A total of 60 @entity1 were treated arthroscopically in 30 ankles. We diagnosed 13 lesions preoperatively (22%), and 47 lesions (78%) were discovered during arthroscopy. Of the @entity0 , 5 (17%) had associated anterolateral instability requiring an open reconstruction. Soft-tissue impingement was seen in 6 @entity0 (20%), anterior @entity5 in 4 (13%), loose bodies in 4 (13%), @entity1 in 4 (13%), extensive scar tissue in 24 (80%), extensive @entity3 in 7 (23%), @entity2 in 2 (7%), and a torn posterior transverse tibiofibular ligament in 2 (5%). Postoperative American Orthopaedic Foot _ Ankle Society and Karlsson scores were significantly improved compared with preoperative scores. @entity0 with chronic complaints before surgery had better outcome scores than @entity0 with an isolated, acute twisting injury. It is unclear whether the incidental pathology discovered at the time of arthroscopic examination influenced outcome measures. CONCLUSIONS: All @entity0 with peroneal @entity4 had associated intra-articular pathology, with the majority of @entity0 having more than 1 intra-articular lesion. For @entity0 meeting surgical criteria, correction of the @entity4 and arthroscopic treatment of the @entity1 produced statistically significantly improved results and @entity0 satisfaction, paralleling historical controls. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

title: XXXX : associated arthroscopic findings and results after repair.

answer: @entity4


abstract: BACKGROUND: Improvement 1-2 years after @entity6 is well established but the pattern thereafter is unclear. Past studies have not examined representative @entity6 populations and typically report findings in terms of functioning across social, @entity5 , or cognitive domains rather than global outcome. OBJECTIVE: To determine the late outcome of a representative cohort of @entity0 admitted to hospital after a @entity6 5-7 years previously and to identify early and late factors correlating with persisting disability and change between one and 5-7 years. METHODS: A representative cohort of head injured @entity0 whose outcome one year after @entity2 was reported previously, were followed up 5-7 years after @entity2 . @entity0 were assessed using structured and validated measures of global outcome (Glasgow Outcome Scale Extended), @entity1 , @entity5 , health status, and social factors. RESULTS: Of 475 survivors studied at one year, 115 (24%) had died by seven years. In survivors at 5-7 years, disability remained frequent (53%); and the rate, similar to that found at one year (57%). Sixty three @entity0 (29%) had improved but 55 (25%) deteriorated. The persistence of disability and its development after previous recovery each showed stronger associations with indices of @entity4 , @entity3 , and low self-esteem than with initial severity of @entity2 or persisting @entity1 . CONCLUSIONS: Admission to hospital after @entity6 is followed 5-7 years later by disability in a high proportion of survivors. Persistence of disability and development of new disability are strongly associated with psychosocial factors that may be open to remediation, even late after @entity2 .

title: Disability in young @entity0 and adults after XXXX : 5-7 year follow up of a prospective cohort study.

answer: @entity6


abstract: BACKGROUND: Improvement 1-2 years after @entity6 is well established but the pattern thereafter is unclear. Past studies have not examined representative @entity6 populations and typically report findings in terms of functioning across social, @entity5 , or cognitive domains rather than global outcome. OBJECTIVE: To determine the late outcome of a representative cohort of @entity0 admitted to hospital after a @entity6 5-7 years previously and to identify early and late factors correlating with persisting disability and change between one and 5-7 years. METHODS: A representative cohort of head injured @entity0 whose outcome one year after @entity2 was reported previously, were followed up 5-7 years after @entity2 . @entity0 were assessed using structured and validated measures of global outcome (Glasgow Outcome Scale Extended), @entity1 , @entity5 , health status, and social factors. RESULTS: Of 475 survivors studied at one year, 115 (24%) had died by seven years. In survivors at 5-7 years, disability remained frequent (53%); and the rate, similar to that found at one year (57%). Sixty three @entity0 (29%) had improved but 55 (25%) deteriorated. The persistence of disability and its development after previous recovery each showed stronger associations with indices of @entity4 , @entity3 , and low self-esteem than with initial severity of @entity2 or persisting @entity1 . CONCLUSIONS: Admission to hospital after @entity6 is followed 5-7 years later by disability in a high proportion of survivors. Persistence of disability and development of new disability are strongly associated with psychosocial factors that may be open to remediation, even late after @entity2 .

title: Disability in young XXXX and adults after @entity6 : 5-7 year follow up of a prospective cohort study.

answer: @entity0


abstract: OBJECT: The authors conducted a study to evaluate and compare prospectively the implantation of either an empty @entity2 fiber composite frame cage (CFCFC) or an iliac crest autograft after @entity7 ( @entity7 ) for @entity6 with monoradiculopathy. METHODS: Thirty-six consecutive @entity0 with one-level @entity3 due to single-level @entity6 were treated by @entity7 , and implantation of either an empty CFCFC (24 @entity0 ) or an iliac crest autograft (12 @entity0 ). Radiological and clinical assessments were performed preoperatively, immediately postoperatively, and at 3, 6, and 12 months postoperatively. Fusion at the 12-month follow-up examination was demonstrated in 96% of the @entity0 in the cage group and in 100% of those in the autograft group. The mean anterior intervertebral body height was 3.7 mm preoperatively and 3.9 mm at 12 months in the CFCFC, @entity4 .8 mm, respectively, in the autograft group. In cage-treated @entity0 , @entity7 , as measured using the visual analog scale (VAS) (Score 0 = minimum; 10 = maximum) decreased from 6.4 preoperatively to 2.0 at 12 months, and @entity1 decreased from 8.4 preoperatively to 1.5 at 12 months. In the autograft group, @entity7 changed from a mean preoperative VAS score of 7.2 to 2.5 at 12 months, and @entity1 decreased from a preoperative mean of 7.8 to 1.4 at 12 months. Analysis of the 12-Item Short Form Health Survey domains and the @entity5 Index scores indicated a significant improvement in both the Physical and Mental Component Summary domains in both groups. CONCLUSIONS: Implantation of an empty CFCFC or a tricortical iliac crest autograft after @entity7 are safe and reliable options for the treatment of @entity6 causing one-sided @entity3 . Both procedures produced equally satisfying clinical and radiological results, leading to a high fusion rate and maintaining intervertebral height. Implantation of an empty CFCFC has the advantages of avoiding any donor site morbidity and requiring a significantly shorter operative time.

title: Implantation of an empty XXXX fiber cage or a tricortical iliac crest autograft after cervical discectomy for single-level @entity6 : a prospective comparative study.

answer: @entity2


abstract: OBJECT: The authors conducted a study to evaluate and compare prospectively the implantation of either an empty @entity2 fiber composite frame cage (CFCFC) or an iliac crest autograft after @entity7 ( @entity7 ) for @entity6 with monoradiculopathy. METHODS: Thirty-six consecutive @entity0 with one-level @entity3 due to single-level @entity6 were treated by @entity7 , and implantation of either an empty CFCFC (24 @entity0 ) or an iliac crest autograft (12 @entity0 ). Radiological and clinical assessments were performed preoperatively, immediately postoperatively, and at 3, 6, and 12 months postoperatively. Fusion at the 12-month follow-up examination was demonstrated in 96% of the @entity0 in the cage group and in 100% of those in the autograft group. The mean anterior intervertebral body height was 3.7 mm preoperatively and 3.9 mm at 12 months in the CFCFC, @entity4 .8 mm, respectively, in the autograft group. In cage-treated @entity0 , @entity7 , as measured using the visual analog scale (VAS) (Score 0 = minimum; 10 = maximum) decreased from 6.4 preoperatively to 2.0 at 12 months, and @entity1 decreased from 8.4 preoperatively to 1.5 at 12 months. In the autograft group, @entity7 changed from a mean preoperative VAS score of 7.2 to 2.5 at 12 months, and @entity1 decreased from a preoperative mean of 7.8 to 1.4 at 12 months. Analysis of the 12-Item Short Form Health Survey domains and the @entity5 Index scores indicated a significant improvement in both the Physical and Mental Component Summary domains in both groups. CONCLUSIONS: Implantation of an empty CFCFC or a tricortical iliac crest autograft after @entity7 are safe and reliable options for the treatment of @entity6 causing one-sided @entity3 . Both procedures produced equally satisfying clinical and radiological results, leading to a high fusion rate and maintaining intervertebral height. Implantation of an empty CFCFC has the advantages of avoiding any donor site morbidity and requiring a significantly shorter operative time.

title: Implantation of an empty @entity2 fiber cage or a tricortical iliac crest autograft after cervical discectomy for single-level XXXX : a prospective comparative study.

answer: @entity6


abstract: BACKGROUND: Increased total @entity5 (tHcy) is an independent risk factor for @entity2 . The measurement of tHcy in blood is therefore of potential great importance especially in @entity0 with @entity3 2 @entity1 . OBJECTIVE: To determine the total @entity5 levels in ambulatory @entity0 with @entity3 2 @entity1 . DESIGN: Cross-sectional, prospective study. SETTING: Outpatient @entity1 clinic of the Kenyatta National Hospital. SUBJECTS: Ambulatory @entity0 with @entity6 . MAIN OUTCOME MEASURES: Serum levels of tHcy, HbA1c, lipids and socio-demographic characteristics. RESULTS: A total of 115 @entity0 , 48% males, with @entity3 2 @entity1 were included in the study. The mean (sd) age of the males was 56.85 (8.96) years and of the females was 55.68 (8.93) years. The mean (sd) total serum @entity5 for males of 12.97 (6.06) micromol/l was significantly higher than that of the females of 10.64 (4.41) micromol/l. The @entity4 , glycated haemoglobin, the body mass index and blood pressure of the study subjects did not show any statistically significant influence on their @entity5 levels. However, increasing age and duration of @entity1 showed a significant linear relationship with rising level of total serum @entity5 . Some study @entity0 reported smoking habit but unreliably. CONCLUSION: There was a significant proportion of the study @entity0 with high levels of serum @entity5 , although most of them were of low to intermediate risk category. It may be prudent to assay @entity5 levels in @entity0 with @entity3 2 @entity1 who are either older or have had @entity1 for long duration for potential intervention.

title: Patterns of @entity5 in Kenyans with XXXX 2 @entity1 without overt @entity2 at Kenyatta National Hospital, Nairobi.

answer: @entity3


abstract: BACKGROUND: Increased total @entity5 (tHcy) is an independent risk factor for @entity2 . The measurement of tHcy in blood is therefore of potential great importance especially in @entity0 with @entity3 2 @entity1 . OBJECTIVE: To determine the total @entity5 levels in ambulatory @entity0 with @entity3 2 @entity1 . DESIGN: Cross-sectional, prospective study. SETTING: Outpatient @entity1 clinic of the Kenyatta National Hospital. SUBJECTS: Ambulatory @entity0 with @entity6 . MAIN OUTCOME MEASURES: Serum levels of tHcy, HbA1c, lipids and socio-demographic characteristics. RESULTS: A total of 115 @entity0 , 48% males, with @entity3 2 @entity1 were included in the study. The mean (sd) age of the males was 56.85 (8.96) years and of the females was 55.68 (8.93) years. The mean (sd) total serum @entity5 for males of 12.97 (6.06) micromol/l was significantly higher than that of the females of 10.64 (4.41) micromol/l. The @entity4 , glycated haemoglobin, the body mass index and blood pressure of the study subjects did not show any statistically significant influence on their @entity5 levels. However, increasing age and duration of @entity1 showed a significant linear relationship with rising level of total serum @entity5 . Some study @entity0 reported smoking habit but unreliably. CONCLUSION: There was a significant proportion of the study @entity0 with high levels of serum @entity5 , although most of them were of low to intermediate risk category. It may be prudent to assay @entity5 levels in @entity0 with @entity3 2 @entity1 who are either older or have had @entity1 for long duration for potential intervention.

title: Patterns of XXXX in Kenyans with @entity3 2 @entity1 without overt @entity2 at Kenyatta National Hospital, Nairobi.

answer: @entity5


abstract: BACKGROUND: Increased total @entity5 (tHcy) is an independent risk factor for @entity2 . The measurement of tHcy in blood is therefore of potential great importance especially in @entity0 with @entity3 2 @entity1 . OBJECTIVE: To determine the total @entity5 levels in ambulatory @entity0 with @entity3 2 @entity1 . DESIGN: Cross-sectional, prospective study. SETTING: Outpatient @entity1 clinic of the Kenyatta National Hospital. SUBJECTS: Ambulatory @entity0 with @entity6 . MAIN OUTCOME MEASURES: Serum levels of tHcy, HbA1c, lipids and socio-demographic characteristics. RESULTS: A total of 115 @entity0 , 48% males, with @entity3 2 @entity1 were included in the study. The mean (sd) age of the males was 56.85 (8.96) years and of the females was 55.68 (8.93) years. The mean (sd) total serum @entity5 for males of 12.97 (6.06) micromol/l was significantly higher than that of the females of 10.64 (4.41) micromol/l. The @entity4 , glycated haemoglobin, the body mass index and blood pressure of the study subjects did not show any statistically significant influence on their @entity5 levels. However, increasing age and duration of @entity1 showed a significant linear relationship with rising level of total serum @entity5 . Some study @entity0 reported smoking habit but unreliably. CONCLUSION: There was a significant proportion of the study @entity0 with high levels of serum @entity5 , although most of them were of low to intermediate risk category. It may be prudent to assay @entity5 levels in @entity0 with @entity3 2 @entity1 who are either older or have had @entity1 for long duration for potential intervention.

title: Patterns of @entity5 in Kenyans with @entity3 2 @entity1 without overt XXXX at Kenyatta National Hospital, Nairobi.

answer: @entity2


abstract: BACKGROUND: Increased total @entity5 (tHcy) is an independent risk factor for @entity2 . The measurement of tHcy in blood is therefore of potential great importance especially in @entity0 with @entity3 2 @entity1 . OBJECTIVE: To determine the total @entity5 levels in ambulatory @entity0 with @entity3 2 @entity1 . DESIGN: Cross-sectional, prospective study. SETTING: Outpatient @entity1 clinic of the Kenyatta National Hospital. SUBJECTS: Ambulatory @entity0 with @entity6 . MAIN OUTCOME MEASURES: Serum levels of tHcy, HbA1c, lipids and socio-demographic characteristics. RESULTS: A total of 115 @entity0 , 48% males, with @entity3 2 @entity1 were included in the study. The mean (sd) age of the males was 56.85 (8.96) years and of the females was 55.68 (8.93) years. The mean (sd) total serum @entity5 for males of 12.97 (6.06) micromol/l was significantly higher than that of the females of 10.64 (4.41) micromol/l. The @entity4 , glycated haemoglobin, the body mass index and blood pressure of the study subjects did not show any statistically significant influence on their @entity5 levels. However, increasing age and duration of @entity1 showed a significant linear relationship with rising level of total serum @entity5 . Some study @entity0 reported smoking habit but unreliably. CONCLUSION: There was a significant proportion of the study @entity0 with high levels of serum @entity5 , although most of them were of low to intermediate risk category. It may be prudent to assay @entity5 levels in @entity0 with @entity3 2 @entity1 who are either older or have had @entity1 for long duration for potential intervention.

title: Patterns of @entity5 in Kenyans with @entity3 2 XXXX without overt @entity2 at Kenyatta National Hospital, Nairobi.

answer: @entity1


abstract: BACKGROUND: In this trial of the treatment of newly diagnosed multiple @entity3 , we compared a protocol that entailed a hematopoietic stem-cell autograft followed by an allograft from an HLA-identical sibling with a protocol of tandem autografts. METHODS: We enrolled 162 consecutive @entity0 with newly diagnosed @entity3 who were 65 years of age or younger and who had at least one sibling. All @entity0 were initially treated with @entity4 , @entity2 , and @entity1 , followed by melphalan and autologous stem-cell rescue. @entity0 with an HLA-identical sibling then received nonmyeloablative total-body irradiation and stem cells from the sibling. @entity0 without an HLA-identical sibling received two consecutive myeloablative doses of melphalan, each of which was followed by autologous stem-cell rescue. The primary end points were overall survival and event-free survival. RESULTS: After a median follow-up of 45 months (range, 21 to 90), the median overall survival and event-free survival were longer in the 80 @entity0 with HLA-identical siblings than in the 82 @entity0 without HLA-identical siblings (80 months vs. 54 months, P=0.01; and 35 months vs. 29 months, P=0.02, respectively). Among @entity0 who completed their assigned treatment protocols, treatment-related mortality did not differ significantly between the double-autologous-transplant group (46 @entity0 ) and the autograft-allograft group (58 @entity0 , P=0.09), but disease-related mortality was significantly higher in the double-autologous-transplant group (43% vs. 7%, P<0.001). The cumulative incidence rates of grades II, III, and IV @entity5 ( @entity5 ) combined and of grade IV @entity5 in the autograft-allograft group were 43% and 4%, respectively. Overall, 21 of 58 @entity0 (36%) were in complete remission after a median follow-up of 38 months (range, 10 to 72) after allografting. Of the 46 @entity0 who received two autografts, 25 (54%) died. CONCLUSIONS: Among @entity0 with newly diagnosed @entity3 , survival in recipients of a hematopoietic stem-cell autograft followed by a stem-cell allograft from an HLA-identical sibling is superior to that in recipients of tandem stem-cell autografts. (ClinicalTrials.gov number, NCT00415987 [ClinicalTrials.gov].).

title: A comparison of allografting with autografting for newly diagnosed XXXX .

answer: @entity3


abstract: OBJECTIVE: The purpose of this study is to examine the oncological safety of breast conserving surgery (BCS) for @entity1 with multifocal @entity0 . SUMMARY BACKGROUND DATA: Few studies have reported about BCS for multifocal @entity0 . BCS for multifocal @entity2 has a risk of local failure in previous reports, whereas recent studies reported the feasibility of BCS. However, because all studies have dealt with a small number of @entity1 , multifocal @entity0 is still considered a relative contraindication for BCS. METHODS: This retrospective study includes 478 @entity1 with multifocal @entity0 who underwent BCS or mastectomy and 930 with unifocal @entity2 who underwent BCS for stage 0-II. @entity2 was defined as 2 or more distinct @entity2 in the same quadrant. Of 478 @entity1 , 147 underwent BCS and 331 underwent mastectomy. We compared the local recurrence rate (LRR), disease free survival, and overall survival for BCS with mastectomy for multifocal @entity2 . In addition, the LRR of BCS for multifocal @entity2 was compared for unifocal @entity2 . RESULTS: There is no significant difference in stage distribution and other clinical and pathologic characteristics except @entity3 for stage IIA between BCS and mastectomy for multifocal @entity2 . The mean follow-up period was 59.33 months (range, 1.00-177.20) for breast conserving group and 64.98 months (range, 6.23-196.03) for mastectomy group. The 5-year overall survival was 93.38% for BCS and 94.53% for mastectomy (log rank P = 0.208). The 5-year disease-free survival was 89.08% for BCS and 91.88% for mastectomy (log rank P = 0.451). The local failure occurred in 3 (2.0%) of 147 @entity1 underwent BCS, 3 (0.9%) of 331 @entity1 underwent mastectomy (P = 0.378). Compared with BCS for unifocal @entity2 @entity1 , the LRR of @entity1 with multifocal @entity2 was not statistically different (2.0% for multifocal, 1.3% for unifocal; P = 0.445). CONCLUSIONS: Our study demonstrates that BCS for multifocal @entity0 is oncologically safe in selected @entity1 .

title: Breast conserving surgery for multifocal XXXX .

answer: @entity0


abstract: OBJECTIVE: To evaluate the significance of multifocality on @entity4 ( @entity4 ) in @entity0 with @entity3 ( @entity3 ) and establish a data-derived, prognostically and therapeutically useful definition of sarcomatosis. SUMMARY BACKGROUND DATA: The incidence, clinical features, and prognostic significance of multifocality in @entity3 is unknown. No current standardized definition for sarcomatosis is available. METHODS: We conducted a retrospective analysis of 393 @entity0 with primary or recurrent nonmetastatic @entity3 treated at a comprehensive @entity1 center between 1996 and 2006. Baseline and treatment variables were compared in @entity0 with @entity2 . A multivariate model was used to evaluate the association of multifocality and @entity4 and identify additional prognostic factors in @entity0 with @entity2 . RESULTS: The median follow-up time for all @entity0 was 69 months; 79 @entity0 (20%) presented with @entity2 . The 5-year @entity4 rate was less in the multifocal group compared with the unifocal group (31% vs. 60%, respectively; P < 0.0001). After multivariate analysis, multifocality remained an independent predictor of worse @entity4 {hazard ratio (HR) 1.7 (95% confidence interval (CI), 1.2-2.5); P = 0.004}. Additionally, @entity0 with more @entity1 had significantly worse prognosis (>7 @entity1 , HR 2.1 (95% CI, 1.1-3.9); P = 0.03), with a 5-year @entity4 rate of 7%. CONCLUSIONS: Multifocal @entity3 is associated with worse @entity4 in @entity0 with either primary or recurrent @entity3 ; @entity0 with >7 @entity1 had the worst prognosis. This criterion can be used to define sarcomatosis, thereby identifying @entity0 whose survival will ultimately depend on effective systemic therapy.

title: Multifocality in XXXX : a prognostic factor critical to surgical decision-making.

answer: @entity3


abstract: OBJECTIVE: To determine whether imputed data can be used to produce unbiased hospital quality measures. BACKGROUND: Different methods for handling missing data may influence which hospitals are designated as quality outliers. METHODS: Monte-Carlo simulation study based on 63,020 @entity0 with no missing data in 68 hospitals using the National @entity1 Data Bank (NTDB, version 6.1). @entity0 were assigned missing data for the motor component of the Glasgow @entity2 scale (GCS) conditional on their observed clinical risk factors. Multiple imputation was then used to "fill in" the missing data. Hospital risk-adjusted quality measures (observed-to-expected mortality ratio) based either on (1) imputed data, (2) excluding @entity0 with missing data (complete case analysis), or (3) excluding the predictor with missing data were compared with hospital quality based on the true data (no missing data). Pair-wise comparisons of hospital quality were performed using the intraclass correlation coefficient (ICC) and the kappa statistic. RESULTS: With 10% of the data missing, the level of agreement between multiple imputation and the true data (ICC = 0.99 and kappa = 0.87) was better compared with the level of agreement between complete case analysis and the true data (ICC = 0.93 and kappa = 0.62). Excluding the predictor (motor GCS) with missing data from the risk adjustment model resulted in the least amount of agreement with quality assessment based on the true data (ICC = 0.88 and kappa = 0.46). CONCLUSION: Multiple imputation can be used to impute missing data and yields hospital quality measures that are nearly identical to those based on the true data. Simply excluding @entity0 with missing data or excluding risk factors with missing data from hospital quality assessment yields substantially inferior quality measures.

title: Impact of statistical approaches for handling missing data on XXXX center quality.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Autoantibodies against antigens in oxidized low-density lipoprotein are common in @entity0 ; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the @entity3 -modified peptide corresponding @entity6 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid @entity2 ( @entity2 ). METHODS: IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, @entity5 , @entity7 , or @entity5 / @entity7 in 751 individuals participating in the BCAPS. Carotid @entity2 was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. RESULTS: Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of @entity1 both at 18 (r=0.09, P<0.05) and 36 months (r=0.12, P<0.005). At 36 months, the difference in @entity2 progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm (95% CI=0.005 to 0.018 mm, P<0.0001). Treatment with @entity7 markedly decreased the progression of @entity2 among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and @entity4 progression. CONCLUSIONS: IgM against the @entity3 -modified peptide corresponding @entity6 3136 and 3155 in apo B-100 is common in subjects with asymptomatic @entity1 , and high levels are associated with a more rapid progression of @entity4 . The observation that the effect of @entity7 was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group.

title: Association between IgM against an @entity3 -modified peptide in apolipoprotein B-100 and progression of XXXX .

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Autoantibodies against antigens in oxidized low-density lipoprotein are common in @entity0 ; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the @entity3 -modified peptide corresponding @entity6 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid @entity2 ( @entity2 ). METHODS: IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, @entity5 , @entity7 , or @entity5 / @entity7 in 751 individuals participating in the BCAPS. Carotid @entity2 was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. RESULTS: Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of @entity1 both at 18 (r=0.09, P<0.05) and 36 months (r=0.12, P<0.005). At 36 months, the difference in @entity2 progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm (95% CI=0.005 to 0.018 mm, P<0.0001). Treatment with @entity7 markedly decreased the progression of @entity2 among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and @entity4 progression. CONCLUSIONS: IgM against the @entity3 -modified peptide corresponding @entity6 3136 and 3155 in apo B-100 is common in subjects with asymptomatic @entity1 , and high levels are associated with a more rapid progression of @entity4 . The observation that the effect of @entity7 was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group.

title: Association between IgM against an XXXX -modified peptide in apolipoprotein B-100 and progression of @entity1 .

answer: @entity3


abstract: OBJECTIVES: To estimate the percentage of @entity0 with @entity16 ( @entity16 ) attending urology or gynaecology outpatient clinics who show associated diseases which complicate their clinical state and quality of life. METHODS: This is an epidemiologic, cross-sectional and multicentre real world trial. 1,659 @entity0 with @entity16 were studied in urology or gynaecology outpatient clinics. Demographic data, anthropometric data, presence of @entity6 ( @entity5 , @entity1 , @entity4 , @entity3 , @entity14 , cognitive damaged, @entity7 , @entity13 and @entity15 ), presence of associated diseases (falls, lower @entity10 , genital @entity9 , @entity11 , @entity8 and @entity2 ), presence of @entity12 and impact on quality of life according to ICIQ-UI SF score. RESULTS: Mean age (S.D) of studied sample was 59.2 (12.9) years and 73.6% were female. Most @entity0 lived in urban settings (67.3%), had primary studies or less (56.8%) and had active work or at home work (66.2%). Most frequent diseases associated to @entity16 , lower @entity10 and @entity2 . @entity8 was more frequent in males than in females; lower @entity10 , genital @entity9 and @entity11 were more frequent in females than in males. @entity0 with these diseases showed higher ICIQ-UI SF scores than @entity0 without them, indicating higher impact. CONCLUSIONS: Presence of associated diseases in @entity0 with @entity16 is frequent in males and females and it is associated to higher impact in @entity0 's life. It seems relevant to pay attention in detecting them through the medical history of @entity0 consulting about @entity16 or @entity12 .

title: [Comorbidity associated to XXXX ].

answer: @entity16


abstract: OBJECTIVE: Numerous studies have identified an association between @entity6 and vestibular symptoms, such as dizziness, vertigo, and motion sensitivity. Using bipolar, binaural @entity2 ( @entity2 ), our objectives were to (1) determine the degree of vestibular sensitivity in borderline @entity1 sufferers, and (2) characterize the postural response to vestibular perturbation in these individuals. METHODS: Fourteen volunteers participated in this study: 8 individuals with @entity6 (6 with @entity5 and 2 with @entity4 ( @entity4 )), and 6 healthy control subjects. Thirty trials of 15-second duration were conducted across 6 conditions ( @entity2 left (L) or right (R), or no stimulation (No @entity2 ) with either @entity3 closed (EC)). Peak medial-lateral (M-L) centre of pressure (CoP) was calculated during quiet stance. RESULTS: @entity1 subjects demonstrated significantly higher peak displacement of the M-L CoP than control subjects (p=0.0461). Although peak M-L CoP in both the EO (p = 0.0753) and EC (p=0.09623) visual conditions were not significantly different between @entity1 sufferers compared to healthy controls, there is some suggestion that @entity0 with @entity6 may use vestibular information to a greater extent and that the presence of vision may not sufficiently compensate for vestibular induced instability. The initial push M-L CoP was not significantly different between groups, suggesting different sensory contributions for the initial and latter response to @entity2 . CONCLUSIONS: @entity0 with @entity6 exhibit increased postural sway, which may reflect the re-weighting of sensory information with an increased vestibular and a reduced visual contribution to postural control. SIGNIFICANCE: These results support existing research on @entity2 in @entity6 sufferers that may provide a basis for future treatment therapies.

title: Increased vestibular contribution to posture control in individuals with XXXX .

answer: @entity6


abstract: AIM OF THE STUDY: To evaluate the ability of VEMP to disclose spatial dissemination of @entity1 . MATERIALS AND METHODS: Forty-six @entity1 @entity0 with auditory and/or vestibular symptoms were studied. @entity0 were divided in two groups. Group 1 included 24 @entity0 with brainstem MRI findings, and Group 2 included 22 @entity0 without MRI findings. VEMP and BAEP have been recorded and assessed. RESULTS: Abnormal p13n23 wave was observed in 50%, while unilateral absence or bilateral delay of the n34p44 in 43% of the @entity0 . The overall diagnostic value considering abnormal cases suggested by both first and second VEMP waves was increased to 71%. Statistically significant differences revealed between @entity0 and controls for @entity5 latency (p=0.018). The p13n23 was abnormal in 7 @entity0 , although MRI scanning did not reveal @entity2 . In 9 out of 18 @entity1 @entity0 suffering from @entity3 , n34p44 was present in the unaffected ears and absent in the affected side, although p13n23 was normal. CONCLUSION: Abnormal VEMP imply the presence of lesions undetected by MRI neuroimaging, which verifies the diagnostic value of the method. Unilateral absence of n34p44 complex was related with @entity4 , supporting the hypothesis that n34p44 is of cochlear origin.

title: The diagnostic value of earlier and later components of Vestibular Evoked Myogenic Potentials (VEMP) in XXXX .

answer: @entity1


abstract: BACKGROUND: Neovascularization was shown to be critically involved in the progression of @entity2 , and treatment approaches targeting @entity2 -associated @entity5 provide convincing results in recent years in some @entity2 entities. However, little is known about the @entity2 -associated @entity5 in @entity3 . The present study was conducted to analyze @entity2 -associated @entity5 in @entity3 and to determine its influence on @entity2 growth, @entity1 , recurrence, and prognosis. METHODS: We analyzed tissue specimens of @entity3 (n = 60) by immunohistochemistry using the endothelial-specific antibody @entity4 and subsequently quantified the microvessel density (MVD). The MVD was correlated with clinicopathological characteristics and recurrence pattern of the @entity2 as well as survival of @entity0 . RESULTS: @entity3 revealed a high degree of vascularization, with a calculated mean MVD of 28.1 +/- 14.5 vessels. @entity2 with a high MVD had a significant higher incidence of lymph node involvement (P = 0.009) and local recurrence (P < 0.001). Furthermore, a high MVD was identified to be a significant overall survival disadvantage (3-year, 28% vs. 93%; 5-year, 8% vs. 78%; P < 0.001) as well as disease-free survival disadvantage (3-year, 7% vs. 88%, 5-year, 7% vs. 72%; P < 0.001), with MVD representing an independent prognostic factor for survival. CONCLUSIONS: Neovascularization is associated with nodal spread as well as local recurrence and serves as an independent prognostic factor for survival after curative resection of @entity3 . Therefore, @entity2 -associated @entity5 seems to be critically involved in the progression of this @entity2 entity. In addition, @entity5 may represent a potential target in he development of new therapeutic approaches in @entity3 .

title: Microvessel density correlates with lymph node @entity1 and prognosis in XXXX .

answer: @entity3


abstract: BACKGROUND: Neovascularization was shown to be critically involved in the progression of @entity2 , and treatment approaches targeting @entity2 -associated @entity5 provide convincing results in recent years in some @entity2 entities. However, little is known about the @entity2 -associated @entity5 in @entity3 . The present study was conducted to analyze @entity2 -associated @entity5 in @entity3 and to determine its influence on @entity2 growth, @entity1 , recurrence, and prognosis. METHODS: We analyzed tissue specimens of @entity3 (n = 60) by immunohistochemistry using the endothelial-specific antibody @entity4 and subsequently quantified the microvessel density (MVD). The MVD was correlated with clinicopathological characteristics and recurrence pattern of the @entity2 as well as survival of @entity0 . RESULTS: @entity3 revealed a high degree of vascularization, with a calculated mean MVD of 28.1 +/- 14.5 vessels. @entity2 with a high MVD had a significant higher incidence of lymph node involvement (P = 0.009) and local recurrence (P < 0.001). Furthermore, a high MVD was identified to be a significant overall survival disadvantage (3-year, 28% vs. 93%; 5-year, 8% vs. 78%; P < 0.001) as well as disease-free survival disadvantage (3-year, 7% vs. 88%, 5-year, 7% vs. 72%; P < 0.001), with MVD representing an independent prognostic factor for survival. CONCLUSIONS: Neovascularization is associated with nodal spread as well as local recurrence and serves as an independent prognostic factor for survival after curative resection of @entity3 . Therefore, @entity2 -associated @entity5 seems to be critically involved in the progression of this @entity2 entity. In addition, @entity5 may represent a potential target in he development of new therapeutic approaches in @entity3 .

title: Microvessel density correlates with lymph node XXXX and prognosis in @entity3 .

answer: @entity1


abstract: PURPOSE: To evaluate inter- and intrafraction organ motion with an ultrasound-based prostate localization system (BAT) for @entity0 treated with intensity-modulated radiotherapy for @entity1 . @entity0 AND METHODS: After set-up to external skin marks, 260/219 ultrasound-based alignments were performed before/after irradiation in 32 consecutive @entity0 . Image quality was classified as good, satisfactory or poor. @entity0 - and imaging-related parameters were analyzed to identify predictors for poor image quality. Shifts in relation to the treatment planning computed tomography (CT) were recorded before/after irradiation in the superior-inferior (SI), anterior-posterior (AP) and right-left (RL) directions to determine inter-/intrafraction prostate motion. RESULTS: The thickness of tissue anterior to the bladder and bladder volume during the ultrasound localization as well as an inferior prostate position relative to @entity2 (determined in treatment planning CT) were found to be independent predictors of a poor image quality. Interfraction shifts (mean+/-standard deviation: -0.2+/-4.8 [SI], 2.4+/-6.6 [AP] and 1.9+/-4.6 [RL]) varied much stronger than intrafraction shifts (0.0+/-2.0 [SI], 0.6+/-2.2 [AP] and 0.2+/-1.9 [RL]). A larger pressure of the ultrasound probe (determined as a larger reduction of the distance abdominal skin to prostate between the planning CT and the ultrasound) was applied in case of poor image quality, associated with larger systematic posterior prostate displacements. CONCLUSION: Intrafraction prostate shifts are considerably smaller in comparison to interfraction shifts. Bladder filling and a small pressure on the ultrasound probe are crucial to achieve an adequate image quality without systematic prostate displacements.

title: Image-guided radiotherapy for XXXX . Implementation of ultrasound-based prostate localization for the analysis of inter- and intrafraction organ motion.

answer: @entity1


abstract: Presented in this study were three cases of @entity1 undergoing pulmonary venoplasty. In the 3 @entity0 with central type of @entity1 involving pulmonary vein, the main branch of right superior pulmonary vein and the distal end of the superior-lobe vein were occluded. The root part of the vein of right-middle lobe, plus part of vessel of of right superior vein was resected. The right superior vein was reconstructed by continuous 6-0 Prolene sutures. After the operation, the reconstructed was patent and the surgical margin was @entity2 -free. Postoperatively, clinical manifestations and @entity3 did not show any signs of venous blockade. The @entity0 were discharged healed 3 weeks after the operation. The technical details of the surgery were presented, the improvements on the basis of traditional methods were discussed and its clinical application was evaluated. It is concluded that pulmonary venoplasty is a safe and feasible operation. Further improvement of the surgery will help conserve more lung tissue and benefit more @entity0 because of expanded indications.

title: Application of pulmonary venoplasty in the surgical treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: Between January 2001 and January 2005 we performed the exchange of infected total hip arthroplasties in 40 cases. MATERIAL AND METHODS: We applied a two-stage procedure when implant salvage was not possible. Our treatment algorithm included complete removal of the infected material, thorough d  bridement, and repeated revisions until cultures were negative. We then implanted a cemented acetabular @entity2 cup with specific antibiotic addition and a cementless modular stem (reverse modular hybrid endoprosthesis). Appropriate intravenous and oral antibiotic therapy was prescribed. RESULTS: A total of 18 @entity0 and 22 @entity0 (age 48-86 years) were followed up for 4-48 months (mean: 12 months). Up to now 38 have remained @entity1 free; in two cases the treatment failed and a resection arthroplasty had to be performed. There were eight complications intraoperatively (shaft fractures); four of them were treated conservatively and four needed additional stabilization. The mean hip score improved from 21 points initially to 81 points at the last examination. All details are listed in table form. Two-stage revision hip arthroplasty for @entity1 using the inverse modular hybrid technique seems to be a safe and reliable method. Further investigation and a larger number of @entity0 are necessary to confirm these preliminary results.

title: [Two-stage procedure to exchange XXXX . Early results after implantation of a reverse modular hybrid endoprosthesis].

answer: @entity1


abstract: INTRODUCTION: An estimated one-fourth to one-third of @entity0 with @entity4 will experience vertigo associated with their @entity4 attacks. Vestibular @entity4 frequently presents as a diagnostic challenge as objective neurological findings consistent with this entity have not been well described. OBJECTIVE: The aim of this study is to characterize eye movements of @entity0 presenting with @entity2 during attacks of @entity4 . DESIGN: A retrospective study of 26 @entity0 presenting with @entity2 during an acute vestibular @entity4 was performed. All @entity0 were examined while symptomatic during a @entity4 spell, and also while asymptomatic. All @entity0 underwent tests of vestibular function with either bithermal water caloric or rotary chair electronystagmography. RESULTS: The most common @entity0 was a female of perimenopausal age. Spontaneous @entity2 was seen in 19% of @entity0 and @entity2 provoked by horizontal headshaking was seen in 35%. @entity2 could be provoked with positional testing in 100% of symptomatic @entity0 with fixation blocked. The positional @entity2 most commonly was sustained, of low velocity, and could be horizontal, vertical or torsional. Bithermal water caloric or rotary chair tests obtained during symptom-free intervals were normal in all @entity0 . CONCLUSIONS: Although @entity2 characteristics are quite variable during vestibular @entity4 , the finding on examination of low-velocity, sustained @entity2 with positional testing in a young to middle-aged adult @entity0 presenting with vertigo, @entity3 and @entity1 is highly suggestive of vestibular @entity4 as long as the @entity2 dissipates when the @entity0 is free of symptoms.

title: XXXX during attacks of vestibular @entity4 : an aid in diagnosis.

answer: @entity2


abstract: INTRODUCTION: An estimated one-fourth to one-third of @entity0 with @entity4 will experience vertigo associated with their @entity4 attacks. Vestibular @entity4 frequently presents as a diagnostic challenge as objective neurological findings consistent with this entity have not been well described. OBJECTIVE: The aim of this study is to characterize eye movements of @entity0 presenting with @entity2 during attacks of @entity4 . DESIGN: A retrospective study of 26 @entity0 presenting with @entity2 during an acute vestibular @entity4 was performed. All @entity0 were examined while symptomatic during a @entity4 spell, and also while asymptomatic. All @entity0 underwent tests of vestibular function with either bithermal water caloric or rotary chair electronystagmography. RESULTS: The most common @entity0 was a female of perimenopausal age. Spontaneous @entity2 was seen in 19% of @entity0 and @entity2 provoked by horizontal headshaking was seen in 35%. @entity2 could be provoked with positional testing in 100% of symptomatic @entity0 with fixation blocked. The positional @entity2 most commonly was sustained, of low velocity, and could be horizontal, vertical or torsional. Bithermal water caloric or rotary chair tests obtained during symptom-free intervals were normal in all @entity0 . CONCLUSIONS: Although @entity2 characteristics are quite variable during vestibular @entity4 , the finding on examination of low-velocity, sustained @entity2 with positional testing in a young to middle-aged adult @entity0 presenting with vertigo, @entity3 and @entity1 is highly suggestive of vestibular @entity4 as long as the @entity2 dissipates when the @entity0 is free of symptoms.

title: @entity2 during attacks of vestibular XXXX : an aid in diagnosis.

answer: @entity4


abstract: OBJECTIVE: To describe actual and preferred place of @entity2 of Italian @entity1 @entity0 and to analyse the preferences met regarding the place of @entity2 . DESIGN: Mortality follow back survey of 2000 @entity1 deaths, identified with a two stage probability sample representative of the whole country. Information on @entity0 ' experience was gathered from the non-professional caregiver with an interview. A section of the interview covered information on the actual and preferred place of @entity2 of the @entity0 . SETTING: 30 Italian local health districts randomly selected after stratification in four geographical areas. @entity0 : 1900 of 2000 (95.0%) caregivers of @entity1 deaths identified. MAIN OUTCOME MEASURES: Prevalence of actual and preferred places of @entity2 . RESULTS: Valid interviews were obtained for 66.9% (n = 1271) of the caregivers. Place of @entity2 was home for 57.9% of Italian @entity1 @entity0 , hospital for 34.6%, hospice for 0.7%, nursing home for 6.5%, and ambulance for 0.4%. Wide and significant differences within Italy were seen (home deaths ranged between 94.0% in the south and 28.2% in the north east). Home was the preferred place of @entity2 for 93.5% of @entity0 that expressed a preference, with minimal differences within the country (between 89.5% and 99.0%). Overall 67.1% of the sample died in the place where they preferred to die. CONCLUSIONS: Policymakers should encourage health services to focus on ways of meeting individual preferences on place of @entity2 . As home was the preferred place of @entity2 for most @entity1 @entity0 , effective programmes to enable the @entity0 to remain at home should be implemented.

title: Actual and preferred place of XXXX @entity0 . Results from the Italian survey of the dying of @entity1 (ISDOC).

answer: @entity1


abstract: OBJECTIVE: To describe actual and preferred place of @entity2 of Italian @entity1 @entity0 and to analyse the preferences met regarding the place of @entity2 . DESIGN: Mortality follow back survey of 2000 @entity1 deaths, identified with a two stage probability sample representative of the whole country. Information on @entity0 ' experience was gathered from the non-professional caregiver with an interview. A section of the interview covered information on the actual and preferred place of @entity2 of the @entity0 . SETTING: 30 Italian local health districts randomly selected after stratification in four geographical areas. @entity0 : 1900 of 2000 (95.0%) caregivers of @entity1 deaths identified. MAIN OUTCOME MEASURES: Prevalence of actual and preferred places of @entity2 . RESULTS: Valid interviews were obtained for 66.9% (n = 1271) of the caregivers. Place of @entity2 was home for 57.9% of Italian @entity1 @entity0 , hospital for 34.6%, hospice for 0.7%, nursing home for 6.5%, and ambulance for 0.4%. Wide and significant differences within Italy were seen (home deaths ranged between 94.0% in the south and 28.2% in the north east). Home was the preferred place of @entity2 for 93.5% of @entity0 that expressed a preference, with minimal differences within the country (between 89.5% and 99.0%). Overall 67.1% of the sample died in the place where they preferred to die. CONCLUSIONS: Policymakers should encourage health services to focus on ways of meeting individual preferences on place of @entity2 . As home was the preferred place of @entity2 for most @entity1 @entity0 , effective programmes to enable the @entity0 to remain at home should be implemented.

title: Actual and preferred place of @entity1 @entity0 . Results from the Italian survey of the dying of XXXX (ISDOC).

answer: @entity1


abstract: OBJECTIVE: To describe actual and preferred place of @entity2 of Italian @entity1 @entity0 and to analyse the preferences met regarding the place of @entity2 . DESIGN: Mortality follow back survey of 2000 @entity1 deaths, identified with a two stage probability sample representative of the whole country. Information on @entity0 ' experience was gathered from the non-professional caregiver with an interview. A section of the interview covered information on the actual and preferred place of @entity2 of the @entity0 . SETTING: 30 Italian local health districts randomly selected after stratification in four geographical areas. @entity0 : 1900 of 2000 (95.0%) caregivers of @entity1 deaths identified. MAIN OUTCOME MEASURES: Prevalence of actual and preferred places of @entity2 . RESULTS: Valid interviews were obtained for 66.9% (n = 1271) of the caregivers. Place of @entity2 was home for 57.9% of Italian @entity1 @entity0 , hospital for 34.6%, hospice for 0.7%, nursing home for 6.5%, and ambulance for 0.4%. Wide and significant differences within Italy were seen (home deaths ranged between 94.0% in the south and 28.2% in the north east). Home was the preferred place of @entity2 for 93.5% of @entity0 that expressed a preference, with minimal differences within the country (between 89.5% and 99.0%). Overall 67.1% of the sample died in the place where they preferred to die. CONCLUSIONS: Policymakers should encourage health services to focus on ways of meeting individual preferences on place of @entity2 . As home was the preferred place of @entity2 for most @entity1 @entity0 , effective programmes to enable the @entity0 to remain at home should be implemented.

title: Actual and preferred place of @entity1 XXXX . Results from the Italian survey of the dying of @entity1 (ISDOC).

answer: @entity0


abstract: An 11-year-old @entity0 manifested with @entity8 , @entity6 , external @entity9 , @entity7 , @entity3 , @entity4 , and generalized @entity2 (six months). Her elder sister had had uncontrolled @entity2 and @entity8 and died at seven years of age. In the patient, serum @entity5 was high (55 mg/dl). Muscle biopsy revealed characteristic ragged red and ragged blue fibers, diagnostic of @entity12 . Sequencing of the complete mitochondrial genome of the DNA obtained from the muscle biopsy of the @entity0 did not show any characteristic mutation. Four months later, the @entity0 was admitted with a one-week history of @entity11 partialis @entity11 (EPC). EEG revealed Periodic Lateralized Epileptiform Discharges (PLEDs), once in 2-4 seconds, over the right temporo-occipital leads. MRI revealed signal change of right motor cortex, which had restricted diffusion. MR spectroscopy (MRS) from this region revealed lactate peak. EPC remained refractory to multiple anti- @entity1 drugs, immuno-modulators, coenzyme-Q, and @entity10 . This thought provoking report expands the spectrum of mitochondrial cytopathies.

title: @entity11 XXXX in mitochondrial dysfunction: Interesting phenotypic and MRI observations.

answer: @entity11


abstract: An 11-year-old @entity0 manifested with @entity8 , @entity6 , external @entity9 , @entity7 , @entity3 , @entity4 , and generalized @entity2 (six months). Her elder sister had had uncontrolled @entity2 and @entity8 and died at seven years of age. In the patient, serum @entity5 was high (55 mg/dl). Muscle biopsy revealed characteristic ragged red and ragged blue fibers, diagnostic of @entity12 . Sequencing of the complete mitochondrial genome of the DNA obtained from the muscle biopsy of the @entity0 did not show any characteristic mutation. Four months later, the @entity0 was admitted with a one-week history of @entity11 partialis @entity11 (EPC). EEG revealed Periodic Lateralized Epileptiform Discharges (PLEDs), once in 2-4 seconds, over the right temporo-occipital leads. MRI revealed signal change of right motor cortex, which had restricted diffusion. MR spectroscopy (MRS) from this region revealed lactate peak. EPC remained refractory to multiple anti- @entity1 drugs, immuno-modulators, coenzyme-Q, and @entity10 . This thought provoking report expands the spectrum of mitochondrial cytopathies.

title: XXXX @entity11 in mitochondrial dysfunction: Interesting phenotypic and MRI observations.

answer: @entity11


abstract: RATIONALE: Airway remodeling is an important feature of chronic @entity5 that causes irreversible airflow obstruction. Although @entity5 is considered to be a @entity2 disease, the role of @entity9 and @entity10 , the key transcription factors for differentiation toward @entity6 and @entity2 cells, in the pathogenesis of airway remodeling is poorly understood. OBJECTIVES: We therefore examined the effects of @entity10 or @entity9 induction of @entity6 / @entity2 bias on the development of airway remodeling in @entity0 . METHODS: The development of airway remodeling after repeated allergen challenges was analyzed using @entity0 overexpressing either @entity10 or @entity9 . MAIN RESULTS: The degrees of subepithelial @entity3 and airway smooth @entity4 after repeated allergen exposure were significantly enhanced in @entity0 overexpressing @entity10 , compared with wild-type @entity0 . Allergen-induced @entity8 and mucus hypersecretion were significantly lower in @entity0 overexpressing @entity9 than in wild-type @entity0 . Eosinophilic airway inflammation increased in @entity0 overexpressing @entity10 , but decreased in @entity0 overexpressing @entity9 after repeated allergen exposure. Cytokine analysis revealed that the @entity6 / @entity2 cytokine balance shifted to @entity2 in lung homogenates and lung T cells of @entity0 overexpressing @entity10 , whereas this balance shifted to @entity6 in those of @entity0 overexpressing @entity9 after allergen exposure. Lung transforming growth factor-beta and @entity7 levels were associated with the degree of subepithelial @entity3 and @entity1 , respectively. CONCLUSIONS: Overall, the results indicate that development of airway remodeling is regulated by the lung @entity6 / @entity2 bias induced by @entity10 and @entity9 .

title: Transcription factors XXXX and @entity10 regulate development of airway remodeling.

answer: @entity9


abstract: RATIONALE: Airway remodeling is an important feature of chronic @entity5 that causes irreversible airflow obstruction. Although @entity5 is considered to be a @entity2 disease, the role of @entity9 and @entity10 , the key transcription factors for differentiation toward @entity6 and @entity2 cells, in the pathogenesis of airway remodeling is poorly understood. OBJECTIVES: We therefore examined the effects of @entity10 or @entity9 induction of @entity6 / @entity2 bias on the development of airway remodeling in @entity0 . METHODS: The development of airway remodeling after repeated allergen challenges was analyzed using @entity0 overexpressing either @entity10 or @entity9 . MAIN RESULTS: The degrees of subepithelial @entity3 and airway smooth @entity4 after repeated allergen exposure were significantly enhanced in @entity0 overexpressing @entity10 , compared with wild-type @entity0 . Allergen-induced @entity8 and mucus hypersecretion were significantly lower in @entity0 overexpressing @entity9 than in wild-type @entity0 . Eosinophilic airway inflammation increased in @entity0 overexpressing @entity10 , but decreased in @entity0 overexpressing @entity9 after repeated allergen exposure. Cytokine analysis revealed that the @entity6 / @entity2 cytokine balance shifted to @entity2 in lung homogenates and lung T cells of @entity0 overexpressing @entity10 , whereas this balance shifted to @entity6 in those of @entity0 overexpressing @entity9 after allergen exposure. Lung transforming growth factor-beta and @entity7 levels were associated with the degree of subepithelial @entity3 and @entity1 , respectively. CONCLUSIONS: Overall, the results indicate that development of airway remodeling is regulated by the lung @entity6 / @entity2 bias induced by @entity10 and @entity9 .

title: Transcription factors @entity9 and XXXX regulate development of airway remodeling.

answer: @entity10


abstract: OBJECTIVE: In this study, the authors assessed the ability of @entity0 bone marrow derived mesenchymal stem cells (BMDMSCs), in the presence of a growth factor, @entity2 ( @entity2 ) and @entity1 , to act as a scaffold for posterolateral spinal fusion in a @entity0 model. METHODS: Using a @entity0 posterolateral spine fusion model, the experimental study comprised 3 groups. Group 1 was composed of 6 animals that were implanted with 0.08 gram @entity1 only. Group 2 was composed of 6 animals that were implanted with 0.08 gram @entity1 containing 1 x 10(6)/ 60 microL @entity0 of BMDMSCs. Group 3 was composed of 6 animals that were implanted with 0.08 gram @entity1 containing 1 x 10(6)/ 60 microL of @entity0 BMDMSCs and @entity2 1 microG to induce the bony differentiation of the BMDMSCs. @entity0 were assessed using radiographs obtained at 4, 6, and 8 weeks postoperatively. After sacrifice, spines were explanted and assessed by manual palpation, high-resolution microcomputerized tomography, and histological analysis. RESULTS: Radiographic, high-resolution microcomputerized tomographic, and manual palpation revealed spinal fusion in five @entity0 (83%) in Group 2 at 8 weeks. However, in Group 1, three (60%) @entity0 developed fusion at L4-L5 by radiography and two (40%) by manual palpation in radiographic examination. In addition, in Group 3, bone fusion was observed in only 50% of @entity0 by manual palpation and radiographic examination at this time. CONCLUSION: The present study demonstrates that 0.08 gram of @entity1 with 1 x 10(6)/ 60 microL @entity0 of BMDMSCs induced bone fusion. @entity2 , added to differentiate primitive 1 x 10(6)/ 60 microL @entity0 of BMDMSCs did not induce fusion. Based on histologic data, @entity2 appears to induce fibrotic change rather than differentiation to bone by 1 x 10(6)/ 60 microL @entity0 of BMDMSCs.

title: Evaluation of Spinal Fusion Using Bone Marrow Derived Mesenchymal Stem Cells with or without XXXX .

answer: @entity2


abstract: PURPOSE: To evaluate the short-term safety and efficacy of intravitreal bevacizumab for the treatment of @entity3 ( @entity3 ) secondary to @entity4 . DESIGN: Retrospective, noncomparative, interventional case series. @entity0 : Thirteen @entity0 undergoing treatment for recalcitrant uveitic macular @entity1 at one referral center. METHODS: Charts of @entity0 who received one 2.5-mg intravitreal injection of bevacizumab in one eye were reviewed for clinical information including best-corrected Snellen visual acuity (VA), examination findings, optical coherence tomography (OCT) results, and @entity2 angiography results. Kaplan-Meier survival analysis was used to calculate probability success rates. The statistical significance of change in mean retinal thickness and VA was assessed using repeated-measures analysis of variance. MAIN OUTCOME MEASURES: Assessments of changes in best-corrected Snellen VA and OCT retinal thickness were made. RESULTS: Six (46.15%) @entity0 had a decrease in foveal thickness at the end of the follow-up, whereas 5 (38.4%) @entity0 had an improvement of VA by > or =2 lines 84 days or more after the injection. Mean retinal thickness showed a significant decrease over the follow-up (P<0.02). The change in mean logarithm of the minimum angle of resolution VA over the follow-up was not significant (P>0.05). Survival analysis showed that the probability of any improvement in VA increased progressively starting at 6 weeks and reached 81% at 14 weeks. No significant ocular or systemic adverse effects were observed. CONCLUSIONS: These results suggest that a single intravitreal injection of bevacizumab is well tolerated and is associated with short-term improvement in VA and decreased OCT retinal thickness in a considerable proportion of @entity0 with uveitic @entity3 resistant to conventional therapy. Further evaluation of intravitreal bevacizumab for uveitic @entity3 in controlled randomized studies is warranted.

title: Intravitreal bevacizumab for treatment of uveitic macular XXXX .

answer: @entity1


abstract: Previous research has shown that @entity0 with @entity2 have a characteristic cognitive bias, making internal attributions when evaluating negative events. However, there is less clarity about their attributions for positive events. There are suggestions that this cognitive style might be influenced by depressed mood. This study examines attributional style in the @entity2 for positive and negative events, independent of covariant effects of @entity1 . Twenty-five eating-disordered @entity0 and 26 nonclinical @entity0 each completed measures of attributional style, depressed mood, and eating pathology. They also completed a measure of verbal intelligence (to ensure comparability of groups). @entity0 with an @entity2 had a greater tendency to attribute negative situations to the self when compared with nonclinical @entity0 , even when differences in depressed mood were controlled for. There were no comparable differences in positive attributional biases. @entity0 with an @entity2 adopt a self-blaming style when evaluating negative events, and such self-blame is likely to contribute to the maintenance of an @entity2 . This suggests that therapy for the @entity2 should include an element that focuses on highlighting and re-evaluating such interpretations.

title: Attributional style in the XXXX .

answer: @entity2


abstract: OBJECTIVE: To compare survival rates of @entity0 with in-hospital @entity1 due to @entity3 treated with @entity5 , @entity4 , or @entity4 plus @entity5 . DESIGN: Multicenter retrospective medical record review. SETTING: Three academic medical centers in the United States. @entity0 : Hospitalized adult @entity0 who received @entity4 , @entity5 , or a combination for @entity3 between August 1, 2000, and July 31, 2002. MEASUREMENTS AND MAIN RESULTS: Data were collected according to the Utstein style. In-hospital proportion of @entity0 living at 24 hrs and discharge were analyzed using chi-square analysis. Of the 605 @entity0 medical records reviewed, 194 met criteria for inclusion (n=79 for @entity5 , n=74 for @entity4 , n=41 for combination). Available data showed no difference in proportion of @entity0 alive 24 hrs post- @entity1 (p=.39). Cox regression analysis indicated a decreased likelihood of survival in @entity0 with @entity3 as an initial rhythm as compared with those who presented with @entity2 followed by @entity3 and in those @entity0 who received @entity4 as compared with @entity5 . However, only 14 @entity0 (25%) in the @entity4 group received the recommended initial 300-mg intravenous bolus, and @entity4 was administered an average of 8 mins later in the code compared with @entity5 (p<.001). CONCLUSIONS: These results generate the hypothesis that inpatients with @entity1 may have different benefits from @entity5 and @entity4 than previously demonstrated. Inadequate dosing and later administration of @entity4 in the code were two confounding factors in this study. Prospective studies evaluating these agents are warranted.

title: Comparing intravenous @entity4 or XXXX , or both, outcomes for inpatients with pulseless ventricular arrhythmias.

answer: @entity5


abstract: OBJECTIVE: To compare survival rates of @entity0 with in-hospital @entity1 due to @entity3 treated with @entity5 , @entity4 , or @entity4 plus @entity5 . DESIGN: Multicenter retrospective medical record review. SETTING: Three academic medical centers in the United States. @entity0 : Hospitalized adult @entity0 who received @entity4 , @entity5 , or a combination for @entity3 between August 1, 2000, and July 31, 2002. MEASUREMENTS AND MAIN RESULTS: Data were collected according to the Utstein style. In-hospital proportion of @entity0 living at 24 hrs and discharge were analyzed using chi-square analysis. Of the 605 @entity0 medical records reviewed, 194 met criteria for inclusion (n=79 for @entity5 , n=74 for @entity4 , n=41 for combination). Available data showed no difference in proportion of @entity0 alive 24 hrs post- @entity1 (p=.39). Cox regression analysis indicated a decreased likelihood of survival in @entity0 with @entity3 as an initial rhythm as compared with those who presented with @entity2 followed by @entity3 and in those @entity0 who received @entity4 as compared with @entity5 . However, only 14 @entity0 (25%) in the @entity4 group received the recommended initial 300-mg intravenous bolus, and @entity4 was administered an average of 8 mins later in the code compared with @entity5 (p<.001). CONCLUSIONS: These results generate the hypothesis that inpatients with @entity1 may have different benefits from @entity5 and @entity4 than previously demonstrated. Inadequate dosing and later administration of @entity4 in the code were two confounding factors in this study. Prospective studies evaluating these agents are warranted.

title: Comparing intravenous XXXX or @entity5 , or both, outcomes for inpatients with pulseless ventricular arrhythmias.

answer: @entity4


abstract: BACKGROUND: Paralysis of abducens nerve is a very rare complication of lumbar puncture, which is a common procedure most often used for diagnostic and anesthetic purposes. CASE REPORT: A 38-year-old @entity0 underwent surgery for a @entity7 while he was under spinal anesthesia. On the first postoperative day, the @entity0 experienced a severe @entity1 that did not respond to standard nonsteroidal anti-inflammatory medication and hydration. During the second postoperative day, @entity2 and @entity3 occurred. On the fourth postoperative day, @entity2 ceased completely but the @entity0 complained of @entity5 . Examination revealed bilateral strabismus with bilateral @entity6 . His @entity5 resolved completely after 9 weeks and strabismus after 6 months. CONCLUSION: @entity9 following spinal anesthesia is a rare and reversible complication. Spinal anesthesia is still a feasible procedure for both the orthopaedic surgeon and the @entity0 . Other types of anesthesia or performing spinal anesthesia with smaller diameter or atraumatic spinal needles may help decrease the incidence of @entity9 . Informing the @entity0 about the reversibility of the complication is essential during the follow-up because the palsy may last for as long as 6 months. Special attention must be paid to @entity0 positioning following the operation. Recumbency and lying flat should be accomplished as soon as possible to prevent @entity8 and resultant @entity4 . This becomes much more important if the @entity0 has postdural puncture @entity1 .

title: Eye problem following foot surgery-- XXXX as a complication of spinal anesthesia.

answer: @entity9