abstract: UNASSIGNED: Objective: Case-control studies have linked mobile phone use to an increased risk of @entity0 in the most exposed brain areas, the temporal and parietal lobes, although inconsistently. We examined time trends in the incidence rates of @entity1 in New Zealand from 1995 to 2010. Methods: Data from the New Zealand Cancer Registry was used to calculate incidence rates of primary @entity2 , by age, gender, morphology and anatomical site. Log-linear regression analysis was used to assess trends in the annual incidence of primary @entity2 ; annual percentage changes and their 95% confidence intervals were estimated. Results: No consistent increases in all primary @entity2 , @entity0 , or temporal or parietal lobe @entity0 were seen. At ages 10-69, the incidence of all @entity2 declined significantly. Incidence of @entity0 increased at ages over 70. Conclusion: In New Zealand, there has been no consistent increase in incidence rates of primary @entity2 . An increase in @entity0 at ages over 70 is likely to be due to improvements in diagnosis. As with any such studies, a small effect, or one with a latent period of more than 10 to 15 years, cannot be excluded.

title: Trends in incidence of primary XXXX in New Zealand, 1995 to 2010.

answer: @entity2


abstract: BACKGROUND: Defibrillation testing by induction and termination of @entity6 is widely done at the time of implantation of @entity4 ( @entity4 ). We aimed to compare the efficacy and safety of @entity5 implantation without defibrillation testing versus the standard of @entity5 implantation with defibrillation testing. METHODS: In this single-blind, randomised, multicentre, non-inferiority trial (Shockless IMPLant Evaluation [SIMPLE]), we recruited @entity0 aged older than 18 years receiving their first @entity5 for standard indications at 85 hospitals in 18 countries worldwide. Exclusion criteria included pregnancy, awaiting transplantation, particpation in another randomised trial, unavailability for follow-up, or if it was expected that the @entity5 would have to be implanted on the right-hand side of the chest. @entity0 undergoing initial implantation of a Boston Scientific @entity5 were randomly assigned (1:1) using a computer-generated sequence to have either defibrillation testing (testing group) or not (no-testing group). We used random block sizes to conceal treatment allocation from the @entity0 , and randomisation was stratified by clinical centre. Our primary efficacy analysis tested the intention-to-treat population for non-inferiority of no-testing versus testing by use of a composite outcome of @entity2 or failed appropriate shock (ie, a shock that did not terminate a spontaneous episode of @entity6 ). The non-inferiority margin was a hazard ratio (HR) of 1  5 calculated from a proportional hazards model with no-testing versus testing as the only covariate; if the upper bound of the 95% CI was less than 1  5, we concluded that @entity5 insertion without testing was non-inferior to @entity5 with testing. We examined safety with two, 30 day, adverse event outcome clusters. The trial is registered with ClinicalTrials.gov, number NCT00800384. FINDINGS: Between Jan 13, 2009, and April 4, 2011, of 2500 eligible @entity0 , 1253 were randomly assigned to defibrillation testing and 1247 to no-testing, and followed up for a mean of 3  1 years (SD 1  0). The primary outcome of @entity2 or failed appropriate shock occurred in fewer @entity0 (90 [7% per year]) in the no-testing group than @entity0 who did receive it (104 [8% per year]; HR 0  86, 95% CI 0  65-1  14; pnon-inferiority <0  0001). The first safety composite outcome occurred in 69 (5  6%) of 1236 @entity0 with no-testing and in 81 (6  5%) of 1242 @entity0 with defibrillation testing, p=0  33. The second, pre-specified safety composite outcome, which included only events most likely to be directly caused by testing, occurred in 3  2% of @entity0 with no-testing and in 4  5% with defibrillation testing, p=0  08. @entity3 needing intravenous treatment with inotropes or diuretics was the most common adverse event (in 20 [2%] of 1236 @entity0 in the no-testing group vs 28 [2%] of 1242 @entity0 in the testing group, p=0  25). INTERPRETATION: Routine defibrillation testing at the time of @entity5 implantation is generally well tolerated, but does not improve shock efficacy or reduce @entity2 . FUNDING: Boston Scientific and the Heart and @entity1 Foundation (Ontario Provincial office).

title: Cardioverter defibrillator implantation without induction of XXXX : a single-blind, non-inferiority, randomised controlled trial (SIMPLE).

answer: @entity6


abstract: AIMS: The aim was to compare @entity1 to native @entity3 by near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS). METHODS AND RESULTS: Twenty-seven @entity3 (non-transplant) @entity0 and 28 heart transplant recipients undergoing routine surveillance coronary angiography underwent NIRS-IVUS imaging of the left anterior descending coronary artery. In each proximal, middle, and distal coronary artery segment, the maxLCBI4mm [4-mm long segment with maximum lipid core burden index (LCBI)] and corresponding IVUS parameters were compared. MaxLCBI4mm was significantly greater among @entity3 @entity0 than the transplant @entity0 in both proximal and middle coronary artery segments, but not in the distal segment. There was a positive linear correlation between maxLCBI4mm and maximum plaque burden in both groups, but @entity3 @entity0 demonstrated a smaller maxLCBI4mm than transplant recipients among segments with plaque burden <40%. Among segments with a maximum plaque burden >= 40%, native- @entity3 @entity0 had a greater maxLCBI4mm compared with transplant @entity0 (P = 0.015). Calcification was present in 72.9% of native @entity3 and 14.7% of transplant segments (P< 0.001). Among the 165 analysed segments, prevalence of lipid-rich plaque (LRP) with superficial attenuation (30.9 vs. 1.2%, P < 0.001) or calcified LRP (13.6 vs. 2.4%, P = 0.03) was significantly greater in native @entity3 compared with transplant @entity0 . Conversely, the proportion of segments with non-LRP (46.4 vs. 11.1%, P < 0.001) was higher in transplant @entity0 . CONCLUSION: NIRS-IVUS imaging demonstrated early and accelerated lipid accumulation with smaller plaque burden and less @entity2 in @entity0 after heart transplant when compared with @entity0 with native @entity3 .

title: In vivo comparison between XXXX and native @entity3 using near-infrared spectroscopy and intravascular ultrasound.

answer: @entity1


abstract: AIMS: The aim was to compare @entity1 to native @entity3 by near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS). METHODS AND RESULTS: Twenty-seven @entity3 (non-transplant) @entity0 and 28 heart transplant recipients undergoing routine surveillance coronary angiography underwent NIRS-IVUS imaging of the left anterior descending coronary artery. In each proximal, middle, and distal coronary artery segment, the maxLCBI4mm [4-mm long segment with maximum lipid core burden index (LCBI)] and corresponding IVUS parameters were compared. MaxLCBI4mm was significantly greater among @entity3 @entity0 than the transplant @entity0 in both proximal and middle coronary artery segments, but not in the distal segment. There was a positive linear correlation between maxLCBI4mm and maximum plaque burden in both groups, but @entity3 @entity0 demonstrated a smaller maxLCBI4mm than transplant recipients among segments with plaque burden <40%. Among segments with a maximum plaque burden >= 40%, native- @entity3 @entity0 had a greater maxLCBI4mm compared with transplant @entity0 (P = 0.015). Calcification was present in 72.9% of native @entity3 and 14.7% of transplant segments (P< 0.001). Among the 165 analysed segments, prevalence of lipid-rich plaque (LRP) with superficial attenuation (30.9 vs. 1.2%, P < 0.001) or calcified LRP (13.6 vs. 2.4%, P = 0.03) was significantly greater in native @entity3 compared with transplant @entity0 . Conversely, the proportion of segments with non-LRP (46.4 vs. 11.1%, P < 0.001) was higher in transplant @entity0 . CONCLUSION: NIRS-IVUS imaging demonstrated early and accelerated lipid accumulation with smaller plaque burden and less @entity2 in @entity0 after heart transplant when compared with @entity0 with native @entity3 .

title: In vivo comparison between @entity1 and native XXXX using near-infrared spectroscopy and intravascular ultrasound.

answer: @entity3


abstract: Ligation of intersphincteric fistula tract in treatment of @entity2 (LIFT) is being said to have satisfactory results in short and long follow up, with low risk of complications. This study was designed to evaluate the results in @entity0 with complex and recurrent @entity1 in comparison with simple transsphincteric @entity2 . The aim of the study was to present a single-center experience in LIFT procedure in treatment of both @entity2 , including recurrent @entity1 , in comparison with a review of current literature. MATERIAL AND METHODS: A series of 17 @entity0 were qualified to LIFT procedure. 5 @entity0 were treated for simple transsphincteric, 6 for complex @entity1 , 6 with @entity1 recurrent after fistulotomy. Median age was 47, most of the @entity0 were male (16/17). Mean follow up was 11 months. RESULTS: Mean operating time was 55 minutes counting from surgical site disinfection to final dressing of the wound. Of the 17 @entity0 the overall success rate was 53%. As expected, best results were achieved in @entity0 with simple @entity1 (80% success rate), then complex (50%), and recurrent @entity1 (only 33%). There were no early nor late complications of the surgery. CONCLUSION: As expected, in simple transsphincteric @entity1 the results were satisfactory, taking into account low complication rate. Complex and recurrent @entity1 seem to be risk factors of LIFT failure. The results are consistent with data published by other authors, based on the review of the current literature, and it seems there is still room for improvement, so further research is required.

title: Efficacy of lift (ligation of intersphincteric fistula tract) for complex and recurrent XXXX --a single-center experience and a review of the literature.

answer: @entity2


abstract: AIMS: @entity14 use has been associated with increased risk of developing @entity5 2 @entity1 (T2DM), and with impaired glycemic control in T2DM @entity0 . The association between @entity14 use and glycemic control in @entity5 1 @entity1 (T1DM) is unknown. The association between use of statins and glycemic control in T1DM @entity0 without known @entity7 was examined. METHODS: Cross-sectional study of 1093 T1DM @entity0 from the outpatient clinic at Steno @entity1 Center. Physical examination, questionnaires, and echocardiography were performed in all @entity0 . Investigators were blinded to all laboratory measurements. Data were analyzed in uni-and multivariable models. RESULTS: Mean age 49.6 years, 53% @entity0 , mean @entity1 duration 25.5 years, 475 (43.5%) received @entity14 . In baseline analyses @entity14 users tended to be older, have longer @entity1 duration, and have more severe @entity2 . Left ventricular ejection fraction was not associated with @entity14 use. In multivariable models including age, gender, @entity1 duration, BMI, blood pressure, physical activity, family history of @entity3 , physical activity, @entity10 , @entity9 , @entity11 , smoking, @entity6 , ejection fraction, @entity13 , and use of @entity12 /ATII-antagonists, @entity4 , @entity8 -antagonists, betablockers or diuretics, @entity14 use was independently and significantly associated with higher HbA1c (0.2% (95%CI: 0.1; 0.4) (2.0mmol/mol (0.2; 3.8)), p=0.029). CONCLUSIONS: In T1DM, use of statins is independently associated with impaired glycemic control. A causal relationship cannot be determined from this study. Given the benefit on cardiovascular outcome, this should not cause @entity0 to stop @entity14 treatment, but may indicate a need to revisit dose of insulin when starting @entity14 treatment.

title: Statins are independently associated with increased HbA1c in XXXX 1 @entity1 - The Thousand _ 1 Study.

answer: @entity5


abstract: AIMS: @entity14 use has been associated with increased risk of developing @entity5 2 @entity1 (T2DM), and with impaired glycemic control in T2DM @entity0 . The association between @entity14 use and glycemic control in @entity5 1 @entity1 (T1DM) is unknown. The association between use of statins and glycemic control in T1DM @entity0 without known @entity7 was examined. METHODS: Cross-sectional study of 1093 T1DM @entity0 from the outpatient clinic at Steno @entity1 Center. Physical examination, questionnaires, and echocardiography were performed in all @entity0 . Investigators were blinded to all laboratory measurements. Data were analyzed in uni-and multivariable models. RESULTS: Mean age 49.6 years, 53% @entity0 , mean @entity1 duration 25.5 years, 475 (43.5%) received @entity14 . In baseline analyses @entity14 users tended to be older, have longer @entity1 duration, and have more severe @entity2 . Left ventricular ejection fraction was not associated with @entity14 use. In multivariable models including age, gender, @entity1 duration, BMI, blood pressure, physical activity, family history of @entity3 , physical activity, @entity10 , @entity9 , @entity11 , smoking, @entity6 , ejection fraction, @entity13 , and use of @entity12 /ATII-antagonists, @entity4 , @entity8 -antagonists, betablockers or diuretics, @entity14 use was independently and significantly associated with higher HbA1c (0.2% (95%CI: 0.1; 0.4) (2.0mmol/mol (0.2; 3.8)), p=0.029). CONCLUSIONS: In T1DM, use of statins is independently associated with impaired glycemic control. A causal relationship cannot be determined from this study. Given the benefit on cardiovascular outcome, this should not cause @entity0 to stop @entity14 treatment, but may indicate a need to revisit dose of insulin when starting @entity14 treatment.

title: Statins are independently associated with increased HbA1c in @entity5 1 XXXX - The Thousand _ 1 Study.

answer: @entity1


abstract: BACKGROUND: @entity6 is a prognostic factor in @entity0 with @entity5 , but whether @entity4 level can predict clinical outcome of @entity5 ( @entity5 ) remains to be elucidated. We therefore investigated the association of @entity4 with mortality in @entity0 hospitalized for @entity5 .Methods   and   Results:Data for @entity0 hospitalized for @entity5 were drawn from an intramural registry. Biochemistry data, echocardiographic characteristics, and @entity4 level were collected. National Death Registry was linked for the identification of mortality data. Among a total of 1,835 @entity0 (age, 75  13 years, 68% @entity0 ), 794 @entity0 died during follow-up. @entity0 who died were older, had lower hemoglobin and estimated glomerular filtration rate, and higher pulmonary artery systolic pressure, NT-proBNP, and @entity4 . @entity4 was a significant predictor of mortality on univariate analysis (HR @entity3 SD, 1.18; 95% CI: 1.11-1.26) and in multivariate Cox models (HR, 1.15; 95% CI: 1.02-1.29). Survival analysis showed an increasing risk of @entity2 along the quartile distribution of @entity4 level. Given renal function, cardiac performance, and kidney perfusion as major determinants of @entity6 , the prognostic impact of @entity4 level was diminished as renal function deteriorated. CONCLUSIONS: @entity4 level was an independent predictor of mortality in @entity0 hospitalized for @entity5 , but the prognostic impact of @entity6 was @entity1 .

title: Determinants and Prognostic Impact of @entity6 in Hospitalization for Acute XXXX .

answer: @entity5


abstract: BACKGROUND: @entity6 is a prognostic factor in @entity0 with @entity5 , but whether @entity4 level can predict clinical outcome of @entity5 ( @entity5 ) remains to be elucidated. We therefore investigated the association of @entity4 with mortality in @entity0 hospitalized for @entity5 .Methods   and   Results:Data for @entity0 hospitalized for @entity5 were drawn from an intramural registry. Biochemistry data, echocardiographic characteristics, and @entity4 level were collected. National Death Registry was linked for the identification of mortality data. Among a total of 1,835 @entity0 (age, 75  13 years, 68% @entity0 ), 794 @entity0 died during follow-up. @entity0 who died were older, had lower hemoglobin and estimated glomerular filtration rate, and higher pulmonary artery systolic pressure, NT-proBNP, and @entity4 . @entity4 was a significant predictor of mortality on univariate analysis (HR @entity3 SD, 1.18; 95% CI: 1.11-1.26) and in multivariate Cox models (HR, 1.15; 95% CI: 1.02-1.29). Survival analysis showed an increasing risk of @entity2 along the quartile distribution of @entity4 level. Given renal function, cardiac performance, and kidney perfusion as major determinants of @entity6 , the prognostic impact of @entity4 level was diminished as renal function deteriorated. CONCLUSIONS: @entity4 level was an independent predictor of mortality in @entity0 hospitalized for @entity5 , but the prognostic impact of @entity6 was @entity1 .

title: Determinants and Prognostic Impact of XXXX in Hospitalization for Acute @entity5 .

answer: @entity6


abstract: OBJECTIVES: miRNAs play crucial roles in @entity1 tumourigenesis. This study was performed to measure expression and function of @entity4 in @entity0 . MATERIALS AND METHODS: Expression of @entity4 in breast tissues and cell lines (SK-BR-3, DA-MB-435s, MCF-7 and MDA-MB-231, HBL-100) was measured by using real-time RT-PCR. We restored expression of @entity4 in MCF-7 cells to measure its functional roles. Luciferase assays were performed to reveal the target gene of @entity4 . RESULTS: Expression of @entity4 was high in both @entity0 cell lines and specimens, and its overexpression increased @entity0 cell proliferation and invasion. @entity3 ( @entity3 ) is a direct target of @entity4 and overexpression of @entity4 reduced expression of @entity3 . Moreover, @entity3 was repressed, its levels inversely correlated to @entity4 expression. @entity3 rescued @entity4 -induced cell invasion and proliferation. CONCLUSIONS: These results demonstrate that @entity4 @entity2 effect was achieved by targeting @entity3 in @entity1 @entity0 specimens.

title: microRNA-762 promotes XXXX cell proliferation and invasion by targeting @entity3 expression.

answer: @entity0


abstract: OBJECTIVES: miRNAs play crucial roles in @entity1 tumourigenesis. This study was performed to measure expression and function of @entity4 in @entity0 . MATERIALS AND METHODS: Expression of @entity4 in breast tissues and cell lines (SK-BR-3, DA-MB-435s, MCF-7 and MDA-MB-231, HBL-100) was measured by using real-time RT-PCR. We restored expression of @entity4 in MCF-7 cells to measure its functional roles. Luciferase assays were performed to reveal the target gene of @entity4 . RESULTS: Expression of @entity4 was high in both @entity0 cell lines and specimens, and its overexpression increased @entity0 cell proliferation and invasion. @entity3 ( @entity3 ) is a direct target of @entity4 and overexpression of @entity4 reduced expression of @entity3 . Moreover, @entity3 was repressed, its levels inversely correlated to @entity4 expression. @entity3 rescued @entity4 -induced cell invasion and proliferation. CONCLUSIONS: These results demonstrate that @entity4 @entity2 effect was achieved by targeting @entity3 in @entity1 @entity0 specimens.

title: microRNA-762 promotes @entity0 cell proliferation and invasion by targeting XXXX expression.

answer: @entity3


abstract: @entity4 gene, playing an essential role in regulating osteoblast differentiation and chondrocyte maturation, may influence @entity0 ( @entity0 ) and @entity1 , but the genetic variations actually leading to the association remain to be elucidated. Therefore, the aim of this study was to investigate whether the genetic variants in @entity4 are associated with @entity0 and @entity3 risk. This study was performed in three samples from two ethnicities, including 1,300 Chinese Han subjects, 700 Chinese Han subjects (350 with @entity2 and 350 healthy controls) and 2,286 US white subjects. Twenty-eight SNPs in @entity4 were genotyped and tested for associations with hip @entity0 and @entity3 . We identified 3 SNPs in @entity4 significantly associated with hip @entity0 in the Chinese population after multiple testing adjustments, which were @entity5 (P = 1.06*10-4, b: -0.018 for allele C), @entity6 (P = 1.30*10-4, b: -0.018 for allele T), and @entity7 (P = 1.59*10-3, b: -0.015 for allele C), separately. These three SNPs were in high linkage disequilibrium. Haplotype analyses detected two significantly associated haplotypes, including one haplotype in block 2 (P = 9.54*10-4, b: -0.016) where these three SNPs located. SNP @entity7 was also associated with @entity2 (P = 0.043, OR: 1.42) in the Chinese population. The effect on @entity3 risk was consistent with its association with lower @entity0 . However, in the white population, we didn't observe significant associations with hip @entity0 . eQTL analyses revealed that SNPs associated with @entity0 also affected @entity4 mRNA expression levels in Chinese. Our findings, together with the prior biological evidence, suggest that @entity4 could be a new candidate for @entity1 in Chinese population. Our results also reveal an ethnic difference, which highlights the need for further genetic studies in each ethnic group.

title: Genetic Analysis Identifies XXXX as a Novel Gene Affecting Bone Mineral Density and Osteoporotic Fractures in Chinese Population.

answer: @entity4


abstract: Promotora Effectiveness Versus @entity5 Trial ( @entity7 ) is a randomized comparative effectiveness trial of a lifestyle intervention based on the @entity1 Prevention Program delivered by community health workers (or promotoras), @entity5 , and standard care. Eligibility criteria are Hispanic ethnicity, female sex, age>= 20years, fluent Spanish-speaking status, BMI >= 23kg/m(2), and @entity8 . We enrolled 92 @entity0 and randomized them to one of the following three groups: standard care, DPP-based lifestyle intervention, or @entity5 . The primary outcome of the trial is the 12-month difference in weight between groups. Secondary outcomes include the following cardiometabolic markers: BMI, waist circumference, blood pressure, and fasting plasma @entity3 , hemoglobin @entity6 (HbA1c), total @entity2 , @entity4 , LDL @entity2 , HDL @entity2 , and insulin. @entity7 @entity0 are socioeconomically disadvantaged Latinas with a mean annual household income of  15,527  9922 and educational attainment of 9.7  3.6years. Eighty-six percent of @entity0 are foreign born, 20% have a prior history of gestational @entity1 , and 71% have a first-degree relative with diagnosed @entity1 . At baseline, @entity7 @entity0 had a mean age of 45.1  12.5years, weight of 178.8  39.3lbs, BMI of 33.3  6.5kg/m(2), HbA1c of 5.9  0.2%, and waist circumference of 97.4  11.1cm. Mean baseline levels of other cardiometabolic markers were normal. The @entity7 study successfully recruited and randomized an understudied population of Latinas with @entity8 . This trial will be the first U.S. study to test the comparative effectiveness of @entity5 and lifestyle intervention versus standard care among prediabetic adults in a "real-world" setting.

title: The rationale, design, and baseline characteristics of @entity7 : A community-based comparative effectiveness trial of lifestyle intervention and XXXX among Latinas with @entity8 .

answer: @entity5


abstract: Promotora Effectiveness Versus @entity5 Trial ( @entity7 ) is a randomized comparative effectiveness trial of a lifestyle intervention based on the @entity1 Prevention Program delivered by community health workers (or promotoras), @entity5 , and standard care. Eligibility criteria are Hispanic ethnicity, female sex, age>= 20years, fluent Spanish-speaking status, BMI >= 23kg/m(2), and @entity8 . We enrolled 92 @entity0 and randomized them to one of the following three groups: standard care, DPP-based lifestyle intervention, or @entity5 . The primary outcome of the trial is the 12-month difference in weight between groups. Secondary outcomes include the following cardiometabolic markers: BMI, waist circumference, blood pressure, and fasting plasma @entity3 , hemoglobin @entity6 (HbA1c), total @entity2 , @entity4 , LDL @entity2 , HDL @entity2 , and insulin. @entity7 @entity0 are socioeconomically disadvantaged Latinas with a mean annual household income of  15,527  9922 and educational attainment of 9.7  3.6years. Eighty-six percent of @entity0 are foreign born, 20% have a prior history of gestational @entity1 , and 71% have a first-degree relative with diagnosed @entity1 . At baseline, @entity7 @entity0 had a mean age of 45.1  12.5years, weight of 178.8  39.3lbs, BMI of 33.3  6.5kg/m(2), HbA1c of 5.9  0.2%, and waist circumference of 97.4  11.1cm. Mean baseline levels of other cardiometabolic markers were normal. The @entity7 study successfully recruited and randomized an understudied population of Latinas with @entity8 . This trial will be the first U.S. study to test the comparative effectiveness of @entity5 and lifestyle intervention versus standard care among prediabetic adults in a "real-world" setting.

title: The rationale, design, and baseline characteristics of @entity7 : A community-based comparative effectiveness trial of lifestyle intervention and @entity5 among Latinas with XXXX .

answer: @entity8


abstract: Promotora Effectiveness Versus @entity5 Trial ( @entity7 ) is a randomized comparative effectiveness trial of a lifestyle intervention based on the @entity1 Prevention Program delivered by community health workers (or promotoras), @entity5 , and standard care. Eligibility criteria are Hispanic ethnicity, female sex, age>= 20years, fluent Spanish-speaking status, BMI >= 23kg/m(2), and @entity8 . We enrolled 92 @entity0 and randomized them to one of the following three groups: standard care, DPP-based lifestyle intervention, or @entity5 . The primary outcome of the trial is the 12-month difference in weight between groups. Secondary outcomes include the following cardiometabolic markers: BMI, waist circumference, blood pressure, and fasting plasma @entity3 , hemoglobin @entity6 (HbA1c), total @entity2 , @entity4 , LDL @entity2 , HDL @entity2 , and insulin. @entity7 @entity0 are socioeconomically disadvantaged Latinas with a mean annual household income of  15,527  9922 and educational attainment of 9.7  3.6years. Eighty-six percent of @entity0 are foreign born, 20% have a prior history of gestational @entity1 , and 71% have a first-degree relative with diagnosed @entity1 . At baseline, @entity7 @entity0 had a mean age of 45.1  12.5years, weight of 178.8  39.3lbs, BMI of 33.3  6.5kg/m(2), HbA1c of 5.9  0.2%, and waist circumference of 97.4  11.1cm. Mean baseline levels of other cardiometabolic markers were normal. The @entity7 study successfully recruited and randomized an understudied population of Latinas with @entity8 . This trial will be the first U.S. study to test the comparative effectiveness of @entity5 and lifestyle intervention versus standard care among prediabetic adults in a "real-world" setting.

title: The rationale, design, and baseline characteristics of XXXX : A community-based comparative effectiveness trial of lifestyle intervention and @entity5 among Latinas with @entity8 .

answer: @entity7


abstract: BACKGROUND: Intracranial @entity5 are rare among transplant recipients, and @entity13 is responsible for less than 2  % of them. @entity13 , a @entity2 and is difficult to treat. @entity2 involves lungs and eventually disseminates. Primary nocardial @entity5 are rare and we report a case from @entity10 Lanka. CASE PRESENTATION: A 38  year old @entity10 Lankan, who has received his 2nd @entity12 matched live donor transplantation, which was complicated with perinephric @entity7 and @entity3 . He presented with @entity1 , worsening @entity0 and @entity8 . An urgent magnetic resonance image (MRI) showed an occipital abscess with midline shift. Craniotomy and drainage followed by 3  week course of @entity9 and @entity11 , which rendered him symptom free. After 12  months he has stayed recurrence free. Imaging and bacteriology of the respiratory tract failed to demonstrate @entity13 . CONCLUSION: Isolated (Primary) nocardial @entity6 are rare, and have an excellent response to medical therapy. We achieved a good response from a relatively short course of antibiotics (not using @entity14 , due to @entity4 ), where long courses of antibiotic had been the norm.

title: "Primary" nocardial XXXX in a renal transplant patient.

answer: @entity6


abstract: BACKGROUND: @entity4 ( @entity4 ) is a @entity0 particularly common in Dachshunds. The breed is predisposed to early @entity3 and @entity2 ( @entity2 ). When calcified, these severely degenerated discs are visible in spinal radiographs. Since the @entity3 ( @entity3 ) is associated with @entity4 , spinal radiography can be utilized in screening programmes in attempts to diminish the incidence of @entity4 in Dachshunds. Our aims were to estimate the heritability and genetic trend of @entity3 in Dachshunds in Finland and to explore the effect of age at the time of radiographic screening. Since the @entity3 has a highly skewed distribution, a log-transformed @entity3 (lnNCD) was also used as an analysed trait. The variance components for both traits were estimated, using the restricted maximum likelihood method. The fixed effects of breed variant, sex, as well as year of screening and the random effects of litter and animal were included in the model. The genetic trends in the @entity3 and lnNCD were assessed from the estimated breeding values (EBVs) of individual @entity1 by comparing the mean EBV of @entity1 born in different years. The breeding values were estimated, using the best linear unbiased prediction animal model. The pedigree in the genetic analyses included a total of 9027 @entity1 , of which 1567 showed results for NCDs. RESULTS: The heritability estimates of the @entity3 and lnNCD in Dachshunds were high (0.53 and 0.45, respectively). Small genetic improvements were seen as the mean EBVs increased from 100 to 104 and 105 over a 15-year period. The gain in the entire Dachshund population in Finland may differ from that observed, since less than 10 % of the Dachshunds registered have a screening result for @entity3 . Age at the time of the screening did not significantly affect the @entity3 or lnNCD. CONCLUSIONS: We recommend systematic radiographic screening for @entity2 in Dachshunds and adopting EBVs as a tool for selecting breeding @entity1 . Age at the time of the radiographic screening may not be as important as previously suggested.

title: Estimate of heritability and genetic trend of XXXX in Dachshunds in Finland.

answer: @entity2


abstract: BACKGROUND: Combined endoscopic-laparoscopic surgery is a novel technique that can be used to avoid bowel resection for complex @entity4 that are not amenable to colonoscopic resection. OBJECTIVE: The aim of this study was to evaluate the safety and outcomes of combined endoscopic-laparoscopic surgery for complex @entity4 . DESIGN: This study is a retrospective review of consecutive combined endoscopic-laparoscopic surgeries. SETTING: This study was conducted at a single institution. @entity0 : All @entity0 that underwent combined endoscopic-laparoscopic surgery for a @entity4 at our center from October 2009 to October 2013 were followed. Each @entity0 's lesion was assessed by a therapeutic endoscopist before referral for combined endoscopic-laparoscopic surgery, and was deemed unresectable based on size, broad base, or location of the polyp. MAIN OUTCOME MEASURES: Intraoperative and @entity1 , length of hospital stay, and recurrence were the primary outcomes measured. RESULTS: Thirty consecutive @entity0 underwent combined endoscopic-laparoscopic surgery. Twenty (66.7%) @entity0 underwent laparoscopic-assisted colonoscopic polyp excision (10 of these excisions were facilitated by Endoloop placement at the polyp base), 9 (30%) @entity0 underwent colonoscopic-assisted laparoscopic cecectomy, and 1 (3.3%) @entity0 was converted from a colonoscopic-assisted laparoscopic cecectomy to a laparoscopic ileocolic resection. The median length of hospital stay was 2 days (range, 1-16). Twenty-nine (96.7%) of the final pathology results were benign, with 10 (33.3%) showing high-grade @entity3 . One (3.3%) final pathology result was positive for a well-differentiated @entity2 . This @entity0 subsequently underwent a laparoscopic right hemicolectomy and chemotherapy for node-positive disease. One (3.3%) @entity0 experienced a recurrent benign polyp at the previous excision site, which was removed by colonoscopy. The time to detection of recurrence was 274 days. LIMITATIONS: This study looked at a small group of @entity0 , over a short follow-up period. However, all consecutive @entity0 were captured, and there were no losses to follow-up. CONCLUSIONS: Combined endoscopic-laparoscopic surgery for complex benign @entity4 is a safe procedure, with good clinical outcomes and low recurrence rates.

title: Dynamic article: combined endoscopic-laparoscopic surgery for complex XXXX : postoperative outcomes and video demonstration of 3 key operative techniques.

answer: @entity4


abstract: BACKGROUND: This study aims to explore the perception and satisfaction of @entity1 screening by Visual Inspection with @entity2 (VIA) in Meknes-Tafilalet Region among target @entity0 . METHODS: A cross-sectional study was conducted using face-to-face interviews with @entity0 , routinely attending health centers, who met the inclusion criteria. Descriptive analysis was undertaken to report data. RESULTS: A total of 324 @entity0 were included in the study. Results revealed @entity1 (19.6  %) and a very high acceptability of VIA screening (94.5  %). Of the 306 @entity0 screened, 99  % stated that they would recommend the VIA testing to their friends and female relatives. All those @entity0 who were screened negative expressed their intent to repeat the test every three years. Those found VIA positive affirmed they would perform confirmatory explorations. The majority (96.3  %) of the @entity0 believed that screening by VIA could save their lives; @entity1 was a concern for 98.6  %; and only 11.6  % felt anxious about repeating the VIA test. The majority of @entity0 (98.6  %) were satisfied with the service received at the health center. CONCLUSIONS: This study showed that the @entity0 had a strong perception about @entity1 screening and were willing to have further confirmation or future retests.

title: Perception and satisfaction of @entity1 screening by Visual Inspection with XXXX (VIA) at Meknes-Tafilalet Region, Morocco: a population-based cross-sectional study.

answer: @entity2


abstract: BACKGROUND: This study aims to explore the perception and satisfaction of @entity1 screening by Visual Inspection with @entity2 (VIA) in Meknes-Tafilalet Region among target @entity0 . METHODS: A cross-sectional study was conducted using face-to-face interviews with @entity0 , routinely attending health centers, who met the inclusion criteria. Descriptive analysis was undertaken to report data. RESULTS: A total of 324 @entity0 were included in the study. Results revealed @entity1 (19.6  %) and a very high acceptability of VIA screening (94.5  %). Of the 306 @entity0 screened, 99  % stated that they would recommend the VIA testing to their friends and female relatives. All those @entity0 who were screened negative expressed their intent to repeat the test every three years. Those found VIA positive affirmed they would perform confirmatory explorations. The majority (96.3  %) of the @entity0 believed that screening by VIA could save their lives; @entity1 was a concern for 98.6  %; and only 11.6  % felt anxious about repeating the VIA test. The majority of @entity0 (98.6  %) were satisfied with the service received at the health center. CONCLUSIONS: This study showed that the @entity0 had a strong perception about @entity1 screening and were willing to have further confirmation or future retests.

title: Perception and satisfaction of XXXX screening by Visual Inspection with @entity2 (VIA) at Meknes-Tafilalet Region, Morocco: a population-based cross-sectional study.

answer: @entity1


abstract: PURPOSE: To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of @entity2 with the plasma @entity3 ( @entity3 ) level in normal-tension @entity2 (NTG). MATERIALS AND METHODS: We conducted a prospective, cross-sectional study on 25 @entity0 with NTG. Subjects with systemic diseases were excluded. The @entity0 underwent a complete ophthalmic examination and were referred to the Rheumatology Department, where nailfold capillaroscopy and HRV assessment were performed. The @entity0 were assigned to the lowest and highest HRV groups according to the standard deviation value of the qualified normal-to-normal intervals of the HRV assessment. Blood samples from all the subjects were assayed for @entity3 concentrations. RESULTS: The systemic @entity3 level was significantly associated with the nailfold capillaroscopy result (     =   0.439, p   =   0.032). Of the 25 @entity0 , seven had @entity1 ( @entity1 ). The mean @entity3 concentration was 4375.6        2923.2   pg/ml in @entity1 @entity0 and 5932.1        1265.4   pg/ml in @entity0 without @entity1 . However, there was no significant association of HRV parameters or disc @entity1 with the systemic @entity3 level. CONCLUSIONS: The systemic @entity3 level was associated with the nailfold capillaroscopy results in @entity0 with NTG but had no direct association with @entity1 .

title: The Association of Nailfold Capillaroscopy with Systemic XXXX Concentration in Normal-Tension Glaucoma.

answer: @entity3


abstract: UNASSIGNED: Parasitism of the gastrointestinal tract of @entity0 leads to diminished health and productivity of grazing livestock. Anthelmintics are used to decrease parasite loads in @entity0 for improved @entity1 . This critical review and meta-analysis aims to quantify the magnitude of the effect of use of anthelmintic products on production metrics in beef stocker @entity0 . Four databases were searched in March 2013. Eligible studies compared average daily gain (ADG), or @entity1 in stocker @entity0 in northern climates of the United States that received anthelmintic treatments compared with placebo or an alternative anthelmintic treatment. Study results were extracted, and where possible, summary effect measures were calculated. Of 512 citations identified by the search, 9 manuscripts with 23 relevant individual studies were selected. Risk of bias was assessed for all studies included in the review and assessed to be unclear for the majority of the studies. There were 23 studies that assessed the magnitude of effect of anthelmintic use on ADG (summary mean difference in ADG=0.05kg (50g), 95% CI=0.03-0.07kg, p<0.00001). The magnitude of @entity1 associated with anthelmintic use could not be assessed, as measures of precision (standard errors or standard deviations) were not reported in these studies. Overall, the conclusion was made that anthelmintic use is associated with an increased @entity1 . However, the approach to reporting employed by authors for this type of study means that many studies could not be included in the meta-analysis and the magnitude of effect not determined.

title: A critical review and meta-analysis of the magnitude of the effect of anthelmintic use on stocker XXXX production parameters in Northern US States.

answer: @entity0


abstract: UNASSIGNED: @entity4 ( @entity4 ) are rare and comprise only 5-10% of @entity5 . The concentration of eloquent neurological systems and the high rate of @entity2 presentation of AVMs particularly in this location complicate the management of such lesions. New therapeutic options, especially in endovascular neurosurgery, have fundamentally modified the strategy and, also, the outcome of cerebellar AVMs. Between 1995 and 2013, demographic, clinical and angiographic data of cerebral AVMs have been prospectively collected. We analyzed data of @entity0 treated for a cerebellar @entity4 , focusing on the angiographic anatomy. Fifty-nine @entity0 (mean age : 35years, male to female ratio : 2) were consecutively treated for a cerebellar @entity4 . 81.4% of them presented @entity2 at admission. 20 AVMs (33.9%) were in eloquent areas. The Spetzler-Martin grade was I or II in 36 cases (51%). An associated @entity1 was noted in more than 40% of cases and a @entity3 in 70%. The vast majority of cases of this series presented an anatomical risk factor of @entity2 . @entity0 with cerebellar AVMs presented with @entity2 more often than @entity0 with supratentorial AVMs, justifying an aggressive management. The analysis of angio-architecture highlighted the high rate of associated @entity1 that could explain the tendency to bleed of such lesion.

title: Anatomic and angiographic findings of cerebellar XXXX : Report of a single center experience.

answer: @entity4


abstract: We have made a preliminary assessment of the antitumor activity of the @entity2 analog, @entity5 , in leukemic @entity1 . This analog is known to substitute for @entity2 in protein biosynthesis in many prokaryotic and eukaryotic systems. Previous studies with cells grown in vitro indicated that @entity6 caused a marked inhibition of DNA synthesis and viability. The system used in the present study was C57BL/6 x DBA/2 F @entity1 bearing L1210 leukemic cells. Following an i.v. injection of 10 mg @entity6 , the @entity4 of @entity6 in the serum was estimated at 16 min. This finding suggested that frequent injections of high doses of @entity6 would be required for an effect on @entity0 cell proliferation. DNA synthesis by the L1210 cells, assayed by @entity3 incorporation, fell to 9% of the control value after 12 hourly i.p. injections of @entity6 (20 mg each). A constant s.c. infusion of 20 mg/hr for 24 hr caused an 86% inhibition of DNA synthesis. The antitumor activity of @entity6 was tested against L1210, using a 24-hr infusion schedule with treatment starting 24 hr after i.p. inoculation of 10(5) cells. An optimal dose of 18 g/kg body weight produced a median increased lifespan of 44% (p less than 0.005). These results suggest that @entity5 may be useful as an antitumor agent.

title: Antitumor activity of XXXX against L1210 @entity1 leukemia.

answer: @entity5


abstract: We have made a preliminary assessment of the antitumor activity of the @entity2 analog, @entity5 , in leukemic @entity1 . This analog is known to substitute for @entity2 in protein biosynthesis in many prokaryotic and eukaryotic systems. Previous studies with cells grown in vitro indicated that @entity6 caused a marked inhibition of DNA synthesis and viability. The system used in the present study was C57BL/6 x DBA/2 F @entity1 bearing L1210 leukemic cells. Following an i.v. injection of 10 mg @entity6 , the @entity4 of @entity6 in the serum was estimated at 16 min. This finding suggested that frequent injections of high doses of @entity6 would be required for an effect on @entity0 cell proliferation. DNA synthesis by the L1210 cells, assayed by @entity3 incorporation, fell to 9% of the control value after 12 hourly i.p. injections of @entity6 (20 mg each). A constant s.c. infusion of 20 mg/hr for 24 hr caused an 86% inhibition of DNA synthesis. The antitumor activity of @entity6 was tested against L1210, using a 24-hr infusion schedule with treatment starting 24 hr after i.p. inoculation of 10(5) cells. An optimal dose of 18 g/kg body weight produced a median increased lifespan of 44% (p less than 0.005). These results suggest that @entity5 may be useful as an antitumor agent.

title: Antitumor activity of @entity5 against L1210 XXXX leukemia.

answer: @entity1


abstract: @entity4 after extensive loss of functioning small or large intestine might predispose to the development of @entity0 in the residual adapted bowel. To test this hypothesis, male Fischer @entity1 were randomized to receive 85 to 90% jejunoileal resection or bypass, subtotal colectomy, or no operation (controls). One week later, the first of six weekly s.c. injections of @entity5 (15 mg/kg/week) was given. At the 36th week postoperatively, mean body weight after enterectomy or colectomy it was 78 to 79% of control. Adaptation after all three operations was characterized by 22 to 84% increments in villous height and crypt depth in the residual functioning ileum (p = 0.05 to 0.001); the depth of colonic crypts was unchanged. Fewer @entity1 developed @entity6 after enteric bypass (36%) than after any of the other treatments (80 to 91%) (p = 0.01 to 0.001); the depth of colonic crypts was unchanged. Fewer @entity1 developed @entity6 after enteric bypass (36%) than after any of the other treatments (80 to 91%) (p = 0.01 to 0.001). Compared with controls, bypass reduced the number of @entity3 by 77% (p less than 0.001). Although resection did not affect @entity3 yield, it tripled the incidence of @entity0 in the duodenum and jejunum (p = 0.025). Colectomy promoted @entity2 (p less than 0.05). @entity0 were commoner after intestinal resection. the lower frequency of @entity0 after jejunoileal bypass contrasts with enhanced @entity2 after enterectomy or colectomy. Profound reduction in body weight may prevent the promotional effect of @entity4 .

title: Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on @entity5 -induced intestinal XXXX .

answer: @entity2


abstract: @entity4 after extensive loss of functioning small or large intestine might predispose to the development of @entity0 in the residual adapted bowel. To test this hypothesis, male Fischer @entity1 were randomized to receive 85 to 90% jejunoileal resection or bypass, subtotal colectomy, or no operation (controls). One week later, the first of six weekly s.c. injections of @entity5 (15 mg/kg/week) was given. At the 36th week postoperatively, mean body weight after enterectomy or colectomy it was 78 to 79% of control. Adaptation after all three operations was characterized by 22 to 84% increments in villous height and crypt depth in the residual functioning ileum (p = 0.05 to 0.001); the depth of colonic crypts was unchanged. Fewer @entity1 developed @entity6 after enteric bypass (36%) than after any of the other treatments (80 to 91%) (p = 0.01 to 0.001); the depth of colonic crypts was unchanged. Fewer @entity1 developed @entity6 after enteric bypass (36%) than after any of the other treatments (80 to 91%) (p = 0.01 to 0.001). Compared with controls, bypass reduced the number of @entity3 by 77% (p less than 0.001). Although resection did not affect @entity3 yield, it tripled the incidence of @entity0 in the duodenum and jejunum (p = 0.025). Colectomy promoted @entity2 (p less than 0.05). @entity0 were commoner after intestinal resection. the lower frequency of @entity0 after jejunoileal bypass contrasts with enhanced @entity2 after enterectomy or colectomy. Profound reduction in body weight may prevent the promotional effect of @entity4 .

title: Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on XXXX -induced intestinal @entity2 .

answer: @entity5


abstract: OBJECTIVE: To summarize the clinical features of @entity11 ( @entity11 ) and to improve the understanding of this disease. METHODS: A retrospective study was performed on the clinical data of 12 @entity0 with @entity11 including clinical manifestations, laboratory results, imaging findings, treatment, and prognosis. RESULTS: Of the 12 cases, 8 were secondary to @entity8 , and 4 had undergone hematopoietic stem cell transplantation. Manifestations mainly included abdominal distention (4 cases), @entity2 with @entity7 (9 cases), @entity1 (6 cases), and weight increase (10 cases). Biochemical tests revealed varying degrees of @entity4 in all cases. In the coagulation function test, the activated partial thromboplastin time (APTT) was prolonged in 7 cases. Out of the 7 @entity0 who underwent serum D-dimer test, 4 showed elevated serum level of D-dimer. In routine blood tests, 4 cases showed @entity5 and neutrophils. In addition, varying degrees of @entity6 were observed in 9 cases. Eight @entity0 were subjected to color Doppler ultrasound examination, and diffuse @entity2 , inhomogeneous @entity4 , unclear or thinner hepatic veins, hydrothorax/ascites, or @entity1 was observed. @entity3 or hepatic cell infiltration was observed in 2 @entity0 who underwent liver biopsy. Treatments were basically symptomatic and supportive therapies, and the prognosis was good in all @entity0 . CONCLUSIONS: @entity11 should be considered in @entity0 who present with @entity2 , sudden @entity9 , @entity4 and @entity4 after they have received chemotherapy for @entity10 and hematopoietic stem cell transplantation.

title: [Clinical features of XXXX : report of 12 cases].

answer: @entity11


abstract: This study was designed to obtain information on prediction of diet digestibility from near-infrared reflectance spectroscopy (NIRS) scans of faecal spot samples from dairy @entity1 at different stages of lactation and to develop a faecal sampling protocol. NIRS was used to predict diet @entity0 ( @entity0 ) and indigestible neutral detergent fibre content (iNDF) from faecal samples, and @entity0 ( @entity0 ) using iNDF in feed and faecal samples as an internal marker. Acid-insoluble ash (AIA) as an internal digestibility marker was used as a reference method to evaluate the reliability of NIRS predictions. Feed and composite faecal samples were collected from 44 @entity1 at approximately 50, 150 and 250  days in milk (DIM). The estimated standard deviation for @entity1 -specific @entity0 analysed by AIA was 12.3  g/kg, which is small considering that the average was 724  g/kg. The phenotypic correlation between direct faecal @entity0 prediction by NIRS and @entity0 by AIA over the lactation was 0.51. The low repeatability and small variability estimates for direct @entity0 predictions by NIRS were not accurate enough to quantify small differences in @entity0 between @entity1 . In contrast to @entity0 , the repeatability estimates for @entity0 by iNDF and especially for direct faecal iNDF predictions were 0.32 and 0.46, respectively, indicating that developing of NIRS predictions for @entity1 -specific digestibility is possible. A data subset of 20 @entity1 with daily individual faecal samples was used to develop an on-farm sampling protocol. Based on the assessment of correlations between individual sample combinations and composite samples as well as repeatability estimates for individual sample combinations, we found that collecting up to three individual samples yields a representative composite sample. Collection of samples from all the @entity1 of a herd every third month might be a good choice, because it would yield a better accuracy.

title: XXXX -specific diet digestibility predictions based on near-infrared reflectance spectroscopy scans of faecal samples.

answer: @entity1


abstract: BACKGROUND: Hippocrates flagged the value of sleep for good health. Nonetheless, historically, researchers with an interest in developmental psychopathology have largely ignored a possible role for atypical sleep. Recently, however, there has been a surge of interest in this area, perhaps reflecting increased evidence that disturbed or insufficient sleep can result in poor functioning in numerous domains. This review outlines what is known about sleep in the @entity2 diagnoses most relevant to @entity0 and for which associations with sleep are beginning to be understood. While based on a comprehensive survey of the literature, the focus of the current review is on the latest science (largely from 2010). There is a description of both concurrent and longitudinal links as well as possible mechanisms underlying associations. Preliminary treatment research is also considered which suggests that treating @entity1 may result in improvements in behavioural areas beyond sleep quality. FINDINGS: To maximise progress in this field, there now needs to be: (a) greater attention to the assessment of sleep in @entity0 ; (b) sleep research on a wider range of @entity2 ; (c) a greater focus on and examination of mechanisms underlying associations; (d) a clearer consideration ofdevelopmental questions and (e) large-scale well-designed treatment studies. CONCLUSIONS: While sleep problems may sometimes be missed by parents and healthcare providers; hence constituting a hidden risk for other psychopathologies - knowing about these difficulties creates unique opportunities. The current excitement in this field from experts in diverse areas including developmental psychology, clinical psychology, genetics and neuropsychology should make these opportunities a reality.

title: Annual Research Review: Sleep problems in childhood XXXX - a review of the latest science.

answer: @entity2


abstract: A retrograde study was performed in 105 @entity0 operated upon between 1950 and 1972 for a @entity2 . Complete histories were available for 89 @entity0 . Forty-five @entity0 died within the first 3 months after operation. Of the 32 @entity0 who were still alive, 14 @entity0 had been operated upon 20-30 years previously and 18 @entity0 10-19 years previously. Twelve @entity0 died over 3 months after the operation; in 6 cases, recurrence of @entity1 was the cause of @entity3 . Of the 7 @entity0 who were irradiated post-operatively, 5 died. In 26 @entity0 the @entity1 had infiltrated the brain-stem and only 7 @entity0 survived the operation. However, 2 @entity0 are still alive after 25 and 10 years, respectively. The findings indicate that @entity0 operated upon for a localized cerebellar astrocytoms can be considered cured and irradiation and chemotherapy are not warranted. When the @entity1 has infiltrated the brain-stem, a survival period of more than 20 years is possible after partial resection.

title: Remarks on the follow-up of XXXX .

answer: @entity2


abstract: BACKGROUND: Secondary prevention often targets @entity0 who suffer from higher rates of second @entity2 than @entity0 , especially in the early years after first @entity3 . Yet, the occurrence of second @entity2 by certain times also depends on the death rate, which is higher in @entity0 than @entity0 . We compared the risk of sustaining second @entity2 by a certain time between @entity0 and @entity0 remaining alive at that time. METHODS: We retrieved 38,383 hospitalization records of @entity0 aged 60years or older, who were discharged alive after admission for @entity2 surgery between 1990 and 2005 in British Columbia, Canada. The outcome variable was the time to a subsequent @entity2 . RESULTS: During ten years of follow-up, 2,902 (8%) @entity0 sustained a second @entity2 , and 21,428 (56%) died before sustaining a second @entity2 . The risk of second @entity2 in the surviving post- @entity3 @entity0 was higher in @entity0 than in @entity0 : 2% vs 2%, 5% vs 4%, 9% vs 7%, 15% vs 13%, and 35% vs 30% at 1, 2, 3, 5, and 10years after initial @entity1 , respectively, crude @entity4 (95% CI: 1.13-1.39). However, the risk did not differ between @entity0 and @entity0 after adjustment, OR=1.09 (95% CI: 0.98-1.21). CONCLUSIONS: The risk of second @entity2 persists for at least ten years among @entity2 survivors, and therefore secondary prevention should continue beyond an early post- @entity3 period. @entity0 and @entity0 have similar risks of second @entity2 and both should be considered for secondary prevention.

title: Risk of second @entity2 persists for years after initial XXXX .

answer: @entity1


abstract: BACKGROUND: Secondary prevention often targets @entity0 who suffer from higher rates of second @entity2 than @entity0 , especially in the early years after first @entity3 . Yet, the occurrence of second @entity2 by certain times also depends on the death rate, which is higher in @entity0 than @entity0 . We compared the risk of sustaining second @entity2 by a certain time between @entity0 and @entity0 remaining alive at that time. METHODS: We retrieved 38,383 hospitalization records of @entity0 aged 60years or older, who were discharged alive after admission for @entity2 surgery between 1990 and 2005 in British Columbia, Canada. The outcome variable was the time to a subsequent @entity2 . RESULTS: During ten years of follow-up, 2,902 (8%) @entity0 sustained a second @entity2 , and 21,428 (56%) died before sustaining a second @entity2 . The risk of second @entity2 in the surviving post- @entity3 @entity0 was higher in @entity0 than in @entity0 : 2% vs 2%, 5% vs 4%, 9% vs 7%, 15% vs 13%, and 35% vs 30% at 1, 2, 3, 5, and 10years after initial @entity1 , respectively, crude @entity4 (95% CI: 1.13-1.39). However, the risk did not differ between @entity0 and @entity0 after adjustment, OR=1.09 (95% CI: 0.98-1.21). CONCLUSIONS: The risk of second @entity2 persists for at least ten years among @entity2 survivors, and therefore secondary prevention should continue beyond an early post- @entity3 period. @entity0 and @entity0 have similar risks of second @entity2 and both should be considered for secondary prevention.

title: Risk of second XXXX persists for years after initial @entity1 .

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is an autoimmune and @entity1 of the small intestine. There is reasonable evidence linking @entity1 to the initiation and continuation of @entity3 ( @entity3 ) in inflammatory conditions. Atrial @entity4 ( @entity4 ) was suggested as an early marker of @entity3 in previous studies. The objectives of this study were to evaluate atrial electromechanical properties measured by tissue Doppler imaging and simultaneous electrocardiography (ECG) tracing in @entity0 with @entity2 . METHODS: Thirty-nine @entity0 with @entity2 ( @entity2 ), and 26 healthy volunteers, matched for age and sex, were enrolled in the study. Atrial electromechanical properties were measured by using transthoracic echocardiography and surface ECG. Interatrial @entity4 ( @entity4 ), left @entity4 , right intratrial @entity4 were calculated. RESULTS: There was no difference between @entity2 @entity0 and healthy volunteers in terms of basal characteristics. @entity0 with @entity2 had significantly prolonged left and right intraatrial EMDs, and interatrial @entity4 compared to healthy controls (p= 0.03, p= 0.02, p<0.0001, respectively). Interatrial @entity4 was positively correlated with age, disease duration, anti-gliadin IgG, anti-endomysium and disease status. In multiple linear regression, interatrial @entity4 was independently associated with disease duration, anti-endomysium and disease status after adjusting for age and sex. CONCLUSIONS: In the present study, @entity3 were found significantly higher in @entity0 with @entity2 compared with healthy individuals. Measurement of @entity3 might be used to predict the risk of development of @entity3 in @entity0 with @entity2 .

title: Atrial Electromechanical Properties in XXXX .

answer: @entity2


abstract: BACKGROUND: The present study investigates the usefulness of @entity4 -PET/CT (PET/CT) in distinguishing between benign and malignant @entity2 . METHODS: This study includes 4 mature teratomas (MTs) with malignant transformation, 8 @entity3 teratomas (ITs), and 16 MTs that were diagnosed after surgical resection. @entity1 marker values, MRI findings, PET/CT SUVmax values, and other clinical parameters were retrospectively compared with those of 14 @entity0 who had MTs. RESULTS: The median @entity5 was significantly higher for ITs than for MTs (P  =  0.04). The median AFP was significantly higher for ITs than for MTs (P  =  0.0034). The median SUVmax values for MTs with malignant transformation, ITs, and MTs were 18.3 (5.3-23.3), 6.0 (3.6-22.6), and 1.1 (1.0-15.5), respectively. SUVmax was significantly higher in MTs with malignant transformation and ITs than in MTs (P  =  0.004, P  =  0.0007). With a cut-off SUVmax of 3.6 to distinguish between benign and malignant MTs, sensitivity was 100  %, specificity was 81  %, positive predictive value was 80  %, negative predictive value was 100  %, and diagnostic accuracy was 89  % (AUC 0.94). However, one @entity0 with an MT had a high SUVmax corresponding to values in the central nervous system (CNS). CONCLUSIONS: @entity4 -PET/CT has a high diagnostic accuracy in distinguishing between benign and malignant @entity2 . Thus, PET/CT may be useful in cases where the diagnosis is unclear on MRI and other clinical findings. However, some MTs with abundant CNS tissue may have a high SUVmax. Therefore, the diagnosis of a benign or malignant lesion should be made carefully in conjunction with other clinical findings.

title: The usefulness of XXXX -PET/CT in discriminating benign from malignant @entity2 .

answer: @entity4


abstract: BACKGROUND: The present study investigates the usefulness of @entity4 -PET/CT (PET/CT) in distinguishing between benign and malignant @entity2 . METHODS: This study includes 4 mature teratomas (MTs) with malignant transformation, 8 @entity3 teratomas (ITs), and 16 MTs that were diagnosed after surgical resection. @entity1 marker values, MRI findings, PET/CT SUVmax values, and other clinical parameters were retrospectively compared with those of 14 @entity0 who had MTs. RESULTS: The median @entity5 was significantly higher for ITs than for MTs (P  =  0.04). The median AFP was significantly higher for ITs than for MTs (P  =  0.0034). The median SUVmax values for MTs with malignant transformation, ITs, and MTs were 18.3 (5.3-23.3), 6.0 (3.6-22.6), and 1.1 (1.0-15.5), respectively. SUVmax was significantly higher in MTs with malignant transformation and ITs than in MTs (P  =  0.004, P  =  0.0007). With a cut-off SUVmax of 3.6 to distinguish between benign and malignant MTs, sensitivity was 100  %, specificity was 81  %, positive predictive value was 80  %, negative predictive value was 100  %, and diagnostic accuracy was 89  % (AUC 0.94). However, one @entity0 with an MT had a high SUVmax corresponding to values in the central nervous system (CNS). CONCLUSIONS: @entity4 -PET/CT has a high diagnostic accuracy in distinguishing between benign and malignant @entity2 . Thus, PET/CT may be useful in cases where the diagnosis is unclear on MRI and other clinical findings. However, some MTs with abundant CNS tissue may have a high SUVmax. Therefore, the diagnosis of a benign or malignant lesion should be made carefully in conjunction with other clinical findings.

title: The usefulness of @entity4 -PET/CT in discriminating benign from malignant XXXX .

answer: @entity2


abstract: @entity1 site @entity2 was monitored non-destructively at weekly intervals during healing of @entity3 in adult @entity0 . Two groups of 20 @entity0 each were treated with external fixators of two different @entity2 . Four animals from each group were killed at 3, 5, 6, 7, and 8 weeks to determine the bending moments at failure of the healing @entity1 . Normal @entity1 healing was accompanied by characteristic phases in the development of @entity1 site @entity2 . From 0 to 3 weeks there was a period of low and approximately constant @entity2 , followed by a linear increase during 3 to 5 weeks to an approximately three to four times greater @entity2 . The maximum average normalized axial @entity2 were reached at 6 weeks and were 57% ( @entity2 group) and 77% ( @entity2 group) of the untreated contralateral controls. The maximum average normalized failure moments occurred at 8 weeks and were 48% ( @entity2 ) and 44% ( @entity2 ) of controls. The differences due to fixator @entity2 were not statistically significant except for a large increase in failure moments at 3 weeks for the @entity2 group. @entity2 were correlated (r2 = 0.74 and 0.53, respectively) with failure moments, but only during the first 6 weeks. The monitoring technique provides a nondestructive means for following the biomechanical progress of @entity1 healing in an animal model. The occurrence of the characteristic increase in @entity1 site @entity2 at 3 to 5 weeks can also be used to distinguish between normal and abnormal healing.

title: Monitoring the healing of a tibial osteotomy in the XXXX treated with external fixation.

answer: @entity0


abstract: BACKGROUND: Water immersion may cause adverse cardiovascular events, including @entity4 in @entity0 with damaged cardiac muscle, e.g. with @entity3 . So far there have been rather few reports on @entity4 induced by water training in @entity0 with @entity2 ( @entity2 ). The aim of the study was to assess the influence of exercise training in moderately cold water (28-30  C) on @entity4 and physical capacity in stable @entity2 @entity0 with preserved left ventricular (LV) function. METHODS: 62 post-MI male @entity0 , mean age 50.9  7.9 years, participated in 16 @entity5 ( @entity5 ), lasted 55-min, twice a week in water at 28-30  C. Each subject underwent 24h Holter on-land monitoring (Holter-24) once during the study and twice in-water Holter monitoring (Holter-W) during @entity5 . Before and after @entity5 cardiopulmonary exercise test (CPET) was performed. The following parameters were analyzed: peak @entity1 consumption (peak VO   ), mean number of @entity6 ( @entity6 ) and supraventricular ectopic beats (SVEBs) during Holter-24 and Holter-W, the percentage of @entity0 who developed @entity4 during CPET versus Holter-24 and versus Holter-W. RESULTS: @entity5 significantly improved @entity0 ' physical capacity, and more often provoked @entity4 , mainly SVEBs, than CPET or daily activity assessed during Holter-24. During @entity5 58% @entity0 developed @entity6 and 62% SVEBs. CONCLUSIONS: 1. @entity5 provoked @entity4 significantly more often than did CPET and normal daily activity. 2. Owing to @entity5 @entity0 improved their physical capacity which was still maintained at one year follow-up.

title: The influence of water-based training on XXXX in @entity0 with stable @entity2 and preserved left ventricular function.

answer: @entity4


abstract: BACKGROUND: Water immersion may cause adverse cardiovascular events, including @entity4 in @entity0 with damaged cardiac muscle, e.g. with @entity3 . So far there have been rather few reports on @entity4 induced by water training in @entity0 with @entity2 ( @entity2 ). The aim of the study was to assess the influence of exercise training in moderately cold water (28-30  C) on @entity4 and physical capacity in stable @entity2 @entity0 with preserved left ventricular (LV) function. METHODS: 62 post-MI male @entity0 , mean age 50.9  7.9 years, participated in 16 @entity5 ( @entity5 ), lasted 55-min, twice a week in water at 28-30  C. Each subject underwent 24h Holter on-land monitoring (Holter-24) once during the study and twice in-water Holter monitoring (Holter-W) during @entity5 . Before and after @entity5 cardiopulmonary exercise test (CPET) was performed. The following parameters were analyzed: peak @entity1 consumption (peak VO   ), mean number of @entity6 ( @entity6 ) and supraventricular ectopic beats (SVEBs) during Holter-24 and Holter-W, the percentage of @entity0 who developed @entity4 during CPET versus Holter-24 and versus Holter-W. RESULTS: @entity5 significantly improved @entity0 ' physical capacity, and more often provoked @entity4 , mainly SVEBs, than CPET or daily activity assessed during Holter-24. During @entity5 58% @entity0 developed @entity6 and 62% SVEBs. CONCLUSIONS: 1. @entity5 provoked @entity4 significantly more often than did CPET and normal daily activity. 2. Owing to @entity5 @entity0 improved their physical capacity which was still maintained at one year follow-up.

title: The influence of water-based training on @entity4 in @entity0 with stable XXXX and preserved left ventricular function.

answer: @entity2


abstract: BACKGROUND: Water immersion may cause adverse cardiovascular events, including @entity4 in @entity0 with damaged cardiac muscle, e.g. with @entity3 . So far there have been rather few reports on @entity4 induced by water training in @entity0 with @entity2 ( @entity2 ). The aim of the study was to assess the influence of exercise training in moderately cold water (28-30  C) on @entity4 and physical capacity in stable @entity2 @entity0 with preserved left ventricular (LV) function. METHODS: 62 post-MI male @entity0 , mean age 50.9  7.9 years, participated in 16 @entity5 ( @entity5 ), lasted 55-min, twice a week in water at 28-30  C. Each subject underwent 24h Holter on-land monitoring (Holter-24) once during the study and twice in-water Holter monitoring (Holter-W) during @entity5 . Before and after @entity5 cardiopulmonary exercise test (CPET) was performed. The following parameters were analyzed: peak @entity1 consumption (peak VO   ), mean number of @entity6 ( @entity6 ) and supraventricular ectopic beats (SVEBs) during Holter-24 and Holter-W, the percentage of @entity0 who developed @entity4 during CPET versus Holter-24 and versus Holter-W. RESULTS: @entity5 significantly improved @entity0 ' physical capacity, and more often provoked @entity4 , mainly SVEBs, than CPET or daily activity assessed during Holter-24. During @entity5 58% @entity0 developed @entity6 and 62% SVEBs. CONCLUSIONS: 1. @entity5 provoked @entity4 significantly more often than did CPET and normal daily activity. 2. Owing to @entity5 @entity0 improved their physical capacity which was still maintained at one year follow-up.

title: The influence of water-based training on @entity4 in XXXX with stable @entity2 and preserved left ventricular function.

answer: @entity0


abstract: INTRODUCTION: Early recognition and treatment of @entity1 @entity0 requiring @entity2 ( @entity2 ) has been shown to reduce mortality. While many risk factors predicting @entity2 have been demonstrated, there is no universally accepted method or algorithm to identify these @entity0 . We hypothesised that even among experienced @entity1 surgeons, the clinical gestalt of identifying @entity0 who will require @entity2 is unreliable. METHODS: Transfusion and mortality outcomes after @entity1 were observed at 10 U.S. Level-1 @entity1 centres in @entity0 who survived >=  30 min after admission and received >=  1 unit of RBC within 6h of arrival. Subjects who received >=  10 units within 24h of admission were classified as @entity2 @entity0 . @entity1 surgeons were asked the clinical gestalt question "Is the @entity0 likely to be massively transfused?" 10 min after the @entity0 arrival. The performance of clinical gestalt to predict @entity2 was assessed using chi-square tests and ROC analysis to compare gestalt to previously described scoring systems. RESULTS: Of the 1245 @entity0 enrolled, 966 met inclusion criteria and 221 (23%) @entity0 received @entity2 . 415 (43%) were predicted to have a @entity2 and 551(57%) were predicted to not have @entity2 . @entity0 predicted to have @entity2 were younger, more often sustained penetrating @entity1 , had higher ISS scores, higher heart rates, and lower systolic blood pressures (all p<0.05). Gestalt sensitivity was 65.6% and specificity was 63.8%. @entity3 and NPV were 34.9% and 86.2% respectively. CONCLUSION: Data from this large multicenter trial demonstrates that predicting the need for @entity2 continues to be a challenge. Because of the increased mortality associated with delayed therapy, a more reliable algorithm is needed to identify and treat these severely injured @entity0 earlier.

title: Clinical gestalt and the prediction of XXXX after @entity1 .

answer: @entity2


abstract: INTRODUCTION: Early recognition and treatment of @entity1 @entity0 requiring @entity2 ( @entity2 ) has been shown to reduce mortality. While many risk factors predicting @entity2 have been demonstrated, there is no universally accepted method or algorithm to identify these @entity0 . We hypothesised that even among experienced @entity1 surgeons, the clinical gestalt of identifying @entity0 who will require @entity2 is unreliable. METHODS: Transfusion and mortality outcomes after @entity1 were observed at 10 U.S. Level-1 @entity1 centres in @entity0 who survived >=  30 min after admission and received >=  1 unit of RBC within 6h of arrival. Subjects who received >=  10 units within 24h of admission were classified as @entity2 @entity0 . @entity1 surgeons were asked the clinical gestalt question "Is the @entity0 likely to be massively transfused?" 10 min after the @entity0 arrival. The performance of clinical gestalt to predict @entity2 was assessed using chi-square tests and ROC analysis to compare gestalt to previously described scoring systems. RESULTS: Of the 1245 @entity0 enrolled, 966 met inclusion criteria and 221 (23%) @entity0 received @entity2 . 415 (43%) were predicted to have a @entity2 and 551(57%) were predicted to not have @entity2 . @entity0 predicted to have @entity2 were younger, more often sustained penetrating @entity1 , had higher ISS scores, higher heart rates, and lower systolic blood pressures (all p<0.05). Gestalt sensitivity was 65.6% and specificity was 63.8%. @entity3 and NPV were 34.9% and 86.2% respectively. CONCLUSION: Data from this large multicenter trial demonstrates that predicting the need for @entity2 continues to be a challenge. Because of the increased mortality associated with delayed therapy, a more reliable algorithm is needed to identify and treat these severely injured @entity0 earlier.

title: Clinical gestalt and the prediction of @entity2 after XXXX .

answer: @entity1


abstract: BACKGROUND: @entity7 is a medical emergency, and immediate diagnostic steps must be taken to establish the specific cause. Recurrence of @entity7 in @entity0 is not only potentially life-threatening, but also involves or induces @entity2 to the @entity0 through repeated hospitalization with many invasive investigations. CASE PRESENTATION: A 6-year-old @entity0 was diagnosed with recurrent @entity7 caused by @entity3 Pneumonia 23  F. He had received serial imaging studies for identifying the cause. The initial sinus computed tomography (CT) also showed @entity5 without @entity1 . However, after performing nuclear scan, the results showed cerebrospinal fluid (CSF) leaked originating from the right petrooccpital region into the middle ear. Subsequent high resolution CT (HRCT) reports showed focal @entity6 at geniculate ganglion and tympanic segment with tiny high-density spots. The reconstruction HRCT showed multiple bony defects at temporal bone. The magnetic resonance imaging revealed multifocal bony destruction with CSF collection in the right petrous ridge, carotid canal and jugular foramen. Eventually, CSF leakage to the right middle ear was confirmed and this could be the cause of the recurrent bacteria @entity4 in this @entity0 . CONCLUSION: Although recurrent @entity7 in childhood is not common, this case report illustrates that recurrence of @entity4 within a short period should be considered as cause of underline immunologic or anatomic defect.

title: Recurrent XXXX 23  @entity4 due to cerebrospinal fluid leakage from the ear cannel: a case report.

answer: @entity3


abstract: BACKGROUND: @entity7 is a medical emergency, and immediate diagnostic steps must be taken to establish the specific cause. Recurrence of @entity7 in @entity0 is not only potentially life-threatening, but also involves or induces @entity2 to the @entity0 through repeated hospitalization with many invasive investigations. CASE PRESENTATION: A 6-year-old @entity0 was diagnosed with recurrent @entity7 caused by @entity3 Pneumonia 23  F. He had received serial imaging studies for identifying the cause. The initial sinus computed tomography (CT) also showed @entity5 without @entity1 . However, after performing nuclear scan, the results showed cerebrospinal fluid (CSF) leaked originating from the right petrooccpital region into the middle ear. Subsequent high resolution CT (HRCT) reports showed focal @entity6 at geniculate ganglion and tympanic segment with tiny high-density spots. The reconstruction HRCT showed multiple bony defects at temporal bone. The magnetic resonance imaging revealed multifocal bony destruction with CSF collection in the right petrous ridge, carotid canal and jugular foramen. Eventually, CSF leakage to the right middle ear was confirmed and this could be the cause of the recurrent bacteria @entity4 in this @entity0 . CONCLUSION: Although recurrent @entity7 in childhood is not common, this case report illustrates that recurrence of @entity4 within a short period should be considered as cause of underline immunologic or anatomic defect.

title: Recurrent @entity3 23  XXXX due to cerebrospinal fluid leakage from the ear cannel: a case report.

answer: @entity4


abstract: PURPOSE: Racial genetic admixture (RGA), a measure to account for ancestral genetic background that correlates with individual's racial classification, could provide insights on causation of racial disparity in @entity2 ( @entity2 ). Our objective is to evaluate the association of RGA with @entity2 outcomes. METHODS: @entity2 @entity0 enrolled onto the GOG-210 protocol were eligible. A randomized subcohort stratified by stage and self-reported race/ethnicity of black or white was used. Genotyping was performed using custom-selected Ancestry Informative Markers to calculate individual admixture estimates of African and European ancestral background. RESULTS: A total of 149 @entity0 were evaluated (self-reported race: 70 black _ 79 white). Mean RGA for African ancestry for self-reported black @entity0 was 0.65 (range 0.04-0.86); while mean RGA for European ancestry for self-reported white @entity0 was 0.77 (range 0.12-0.88). Progression-free survival (PFS) analysis using proportional hazards models stratified by stage and race revealed that each 0.10 increase in African ancestry was associated with worse PFS with hazard ratio (HR) of 1.11 (95% CI 0.90-1.37). Each 0.10 increase in European RGA was associated with improved PFS with HR of 0.86 (95% CI 0.69-1.07). Using tertiles of African RGA showed increasing risk of progression of @entity1 with increasing African RGA (with 0-5% as reference), HR (95% CIs) for top two tertiles are: 6%-66%: 1.38 (0.64, 2.97), and 67%-86%: 2.27 (0.74, 6.95). CONCLUSION: RGA demonstrated a trend with PFS in self-reported black and white @entity0 with @entity2 . @entity0 with increased levels of African ancestry showed a trend towards worse survival after stratifying by stage/race.

title: The role of racial genetic admixture with XXXX outcomes: An NRG Oncology/Gynecologic Oncology Group study.

answer: @entity2


abstract: OBJECTIVES: A multi-center phase II study was conducted to evaluate the safety and efficacy of neoadjuvant chemotherapy (NAC) with S-1 plus @entity3 for advanced @entity2 . METHODS: The eligibility criteria were clinical T3/T4 or N2, not Stage IV. @entity0 received two 35-day cycles of S-1 plus @entity3 , and then underwent D2 gastrectomy. The primary endpoint was 3-year progression free survival (PFS). Secondary endpoints were ratio of R0 resection, response rate, adverse events, and overall survival. A sample size of 49 was determined to have 80% power for detecting 15% improvement in the 3-year PFS over 55% at a one-sided alpha of 0.1. RESULTS: Among 53 @entity0 enrolled, 44 @entity0 completed two cycles of NAC (83%), and 48 @entity0 underwent R0 resection (91%). @entity1 occurred in 13 @entity0 (26%). A pathological response was confirmed in 24 @entity0 (45%), including four complete responses. The 3-year PFS was 50.7%, while the 3-year OS was 74.9%. CONCLUSIONS: Although the observed 3-year PFS rate was worse than expected, NAC with S1 plus @entity3 was safe and led to a high rate of R0 resection. A randomized controlled trial is needed to make conclusions about the effectiveness of NAC in Japanese @entity0 undergoing D2 resection. J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: A phase II study of neoadjuvant chemotherapy with S-1 and XXXX for stage III gastric cancer: KUGC03.

answer: @entity3


abstract: UNASSIGNED: Healthcare providers use treatments whose effectiveness's derive partially or completely from 'non-specific' factors, frequently referred to as placebo effects. While the ethics of interventional placebo use continues to be debated, evidence suggests that placebos can produce clinically meaningful analgesic effects. Burgeoning evidence suggest that @entity0 with @entity2 may be open to placebos treatments under certain contexts despite limited knowledge of their well-established psycho-neurobiological underpinnings. This investigation sought to examine the effects of a brief, mechanism-based placebo analgesia educational intervention on aspects placebo knowledge and acceptability. @entity0 with chronic @entity3 completed a web-based survey where they rated their knowledge of placebo analgesia; assessed placebo acceptability across different medical contexts; and evaluated six unique @entity0 -provider treatment scenarios to assess the role of treatment effectiveness and deception on @entity0 /provider attributions. Using a pre-post design, @entity0 were randomized to receive either a placebo educational intervention or an active control education. Results demonstrated that the educational intervention greatly improved perceptions of placebo knowledge, effectiveness, and acceptability, even in deceptive treatment contexts. This is the first study of its kind to demonstrate the value of an educational intervention in increasing openness to and knowledge of placebo analgesic interventions among @entity0 with chronic @entity3 . PERSPECTIVE: This article highlights how @entity0 with @entity2 may be open to placebo interventions, particularly adjunct/complementary treatments, when provided education on the neurobiological and psychological mechanisms underlying placebo effects. Study findings highlight ethically acceptable ways to potentially utilize placebo factors to enhance existing @entity1 treatments and improve @entity0 health outcomes.

title: Placebo use in XXXX management: a mechanism-based educational intervention enhances placebo treatment acceptability.

answer: @entity1


abstract: The postoperative prognosis of @entity1 still is unfavourable with regard to both functional restitution and postoperative survival time. Short anamnestic times and severe neurological attacks developing within a short period of time up to a complete transverse @entity3 syndrome characterise the clinical picture. In addition to the usually existing increase in the lumbar cerebrospinal protein level (86 per cent), pathological native X-ray findings are found condierably more frequently than in processes of other topical localisations (72 per cent). In three quarters of the cases the pantopaque myelogram shows complete contrast medium passage disturbances. In 10.8 per cent of the cases, an improvement of the findings could be achieved by an operation, 76.9 per cent showed an unchanged condition up to four weeks post operationem and in 12.3 per cent a deterioration of the condition had occurred. The average survival times of the deceased @entity0 was 4.1 months. Prolonged survival times between three and six years were only seen in two @entity2 @entity0 and one @entity2 @entity0 . The cause of the unfavourable functional results are believed to be due to medullary circulation disturbances which are caused by the @entity1 and can non longer be influenced by an operation. In spite of the results being frequently unfavourable, a general rejection of the operation does not seem to be justified. It should, however, be rejected when (I) a complete transverse lesion syndrome has been present for several months, (2) extensive vertebral destruction can be demonstrated, (3) multiple destruction foci are present and (4) there ist an advanced stage of the primary process with a highly reduced general condition.

title: [Clinical picture of XXXX of the spine].

answer: @entity1


abstract: Diagnostic peritoneal lavage was attempted in 96 out of a consecutive series of 168 attacks of @entity4 , in order to evaluate its ability to predict severe disease. Lavage was successful in 89 instances, and resulted in relief of @entity1 in many @entity0 , and in one complication. Lavage indicated (by the presence of numerous organisms) that the diagnosis was incorrect in 1 @entity0 with suspected @entity4 ; the correct diagnosis, @entity3 , was revealed at post mortem examination. The severity of the attack was predicted by the clinician prior to lavage, and each attack was classified as mild or severe when the @entity0 left hospital according to a simple clinical scheme. Although there was a strong correlations between severe attacks and the concentrations of G. O. T., albumin, protein, @entity7 , @entity5 and @entity6 in the lavage fluid, a simple and immediate classification based upon the physical features of the free peritoneal fluid and the lavage return fluid was adopted. The presence of @entity8 , or more than 10 ml of free fluid, or mild-straw coloured lavage was taken as the lavage criterion of a severe attack. Of the 89 attacks with a successful lavage, 68 were classified as mild and 21 as severe according to the clinical outcome. Clinical assessment of the attack on the day of admission to hospital successfully predicted only 8 (38%) of the severe attacks, but 17 (76%) were correctly predicted by lavage, carried out at an average time of 7 hours after admission. False positive results of lavage were seen in only 4 (6%) of the 68 mild attacks. All attacks in which a shock-like illness developed, or which resulted in @entity2 (4) were predicted as severe by lavage. We feel that diagnostic lavage especially suited to select @entity0 who may be expected to benefit from therapeutic peritoneal lavage.

title: Early prediction of severity of XXXX using peritoneal lavage.

answer: @entity4


abstract: UNASSIGNED: The present study aimed to investigate the clinical features of nasal mucosa malignant @entity2 , including the histopathological features and factors affecting prognosis. A retrospective analysis of the clinical data obtained from the Department of Otolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital (Tianjin, China) between October 1999 and June 2013 was performed using the Kaplan-Meier method. In total, 29 cases of nasal mucosal malignant @entity2 were analyzed. The overall 3- and 5-year survival rates were 48.3 and 27.6%, respectively. The study group consisted of 18 males and 11 females, with a median age of 61.5 years. Overall, 19 @entity0 underwent surgery, 28 received radiotherapy and 17 received chemotherapy. The American Joint Committee on @entity1 staging system (AJCC) was used to retrospectively stage the @entity1 . In total, 8 were @entity1 stage (T)1, 10 were T2, 6 were T3 and 5 were T4. The results revealed that the T stage, surgical treatment, location of the @entity1 and the presence of black pigmentation affected the 5-year survival rate of the @entity0 . By contrast, radiotherapy and chemotherapy had no effect on the overall survival rate. Overall, endoscopic or endoscopic-assisted surgery were the preferred methods of treatment, and histological features, including the presence of @entity1 melanin pigmentation, affected the prognosis of the @entity0 . This study indicated that the AJCC staging system is able to effectively predict the prognosis of @entity0 with nasal mucosa malignant @entity2 .

title: Clinical analysis of 29 cases of nasal mucosal malignant XXXX .

answer: @entity2


abstract: UNASSIGNED: In advanced or relapsed @entity4 , mono- or duo-therapy has shown modest efficacy at best. The present study evaluated the efficacy of a triplet combination in relapsed or advanced @entity4 . A total of 37 @entity0 with @entity3 in stage III/IV or with @entity1 were treated with a @entity2 , @entity10 and @entity6 (GFP) regimen every 3 weeks. Only 29 out of 37 @entity0 were evaluable for response due to early treatment interruption in 8 @entity0 . The overall response rate was 24.1% and the disease control rate was 68.9%. The progression-free survival (PFS) rate was 61.5, 30.9 and 17.6% at 3, 6 and 9 months, respectively, and the @entity7 ( @entity7 ) rate was 46.5 and 30.6% at 6 and 12 months, respectively. Grade 3/4 @entity9 , @entity8 and @entity5 occurred in 18.4, 29.9 and 24.5% of 147 cycles, respectively. Old age and a poor performance status (PS) were associated with the early discontinuation of chemotherapy (P=0.038 and P=0.036, respectively). In @entity0 <65 years old and with a PS of <2, the median PFS and @entity7 times were 5.3 months and 10.3 months, respectively. Overall, although GFP resulted in acceptable response and survival rates, it does not appear to have marked superiority to @entity2 -based single or duplet chemotherapy.

title: Triplet cytotoxic chemotherapy with @entity2 , @entity10 and XXXX for advanced @entity4 .

answer: @entity6


abstract: UNASSIGNED: In advanced or relapsed @entity4 , mono- or duo-therapy has shown modest efficacy at best. The present study evaluated the efficacy of a triplet combination in relapsed or advanced @entity4 . A total of 37 @entity0 with @entity3 in stage III/IV or with @entity1 were treated with a @entity2 , @entity10 and @entity6 (GFP) regimen every 3 weeks. Only 29 out of 37 @entity0 were evaluable for response due to early treatment interruption in 8 @entity0 . The overall response rate was 24.1% and the disease control rate was 68.9%. The progression-free survival (PFS) rate was 61.5, 30.9 and 17.6% at 3, 6 and 9 months, respectively, and the @entity7 ( @entity7 ) rate was 46.5 and 30.6% at 6 and 12 months, respectively. Grade 3/4 @entity9 , @entity8 and @entity5 occurred in 18.4, 29.9 and 24.5% of 147 cycles, respectively. Old age and a poor performance status (PS) were associated with the early discontinuation of chemotherapy (P=0.038 and P=0.036, respectively). In @entity0 <65 years old and with a PS of <2, the median PFS and @entity7 times were 5.3 months and 10.3 months, respectively. Overall, although GFP resulted in acceptable response and survival rates, it does not appear to have marked superiority to @entity2 -based single or duplet chemotherapy.

title: Triplet cytotoxic chemotherapy with @entity2 , @entity10 and @entity6 for advanced XXXX .

answer: @entity4


abstract: UNASSIGNED: In advanced or relapsed @entity4 , mono- or duo-therapy has shown modest efficacy at best. The present study evaluated the efficacy of a triplet combination in relapsed or advanced @entity4 . A total of 37 @entity0 with @entity3 in stage III/IV or with @entity1 were treated with a @entity2 , @entity10 and @entity6 (GFP) regimen every 3 weeks. Only 29 out of 37 @entity0 were evaluable for response due to early treatment interruption in 8 @entity0 . The overall response rate was 24.1% and the disease control rate was 68.9%. The progression-free survival (PFS) rate was 61.5, 30.9 and 17.6% at 3, 6 and 9 months, respectively, and the @entity7 ( @entity7 ) rate was 46.5 and 30.6% at 6 and 12 months, respectively. Grade 3/4 @entity9 , @entity8 and @entity5 occurred in 18.4, 29.9 and 24.5% of 147 cycles, respectively. Old age and a poor performance status (PS) were associated with the early discontinuation of chemotherapy (P=0.038 and P=0.036, respectively). In @entity0 <65 years old and with a PS of <2, the median PFS and @entity7 times were 5.3 months and 10.3 months, respectively. Overall, although GFP resulted in acceptable response and survival rates, it does not appear to have marked superiority to @entity2 -based single or duplet chemotherapy.

title: Triplet cytotoxic chemotherapy with @entity2 , XXXX and @entity6 for advanced @entity4 .

answer: @entity10


abstract: UNASSIGNED: In advanced or relapsed @entity4 , mono- or duo-therapy has shown modest efficacy at best. The present study evaluated the efficacy of a triplet combination in relapsed or advanced @entity4 . A total of 37 @entity0 with @entity3 in stage III/IV or with @entity1 were treated with a @entity2 , @entity10 and @entity6 (GFP) regimen every 3 weeks. Only 29 out of 37 @entity0 were evaluable for response due to early treatment interruption in 8 @entity0 . The overall response rate was 24.1% and the disease control rate was 68.9%. The progression-free survival (PFS) rate was 61.5, 30.9 and 17.6% at 3, 6 and 9 months, respectively, and the @entity7 ( @entity7 ) rate was 46.5 and 30.6% at 6 and 12 months, respectively. Grade 3/4 @entity9 , @entity8 and @entity5 occurred in 18.4, 29.9 and 24.5% of 147 cycles, respectively. Old age and a poor performance status (PS) were associated with the early discontinuation of chemotherapy (P=0.038 and P=0.036, respectively). In @entity0 <65 years old and with a PS of <2, the median PFS and @entity7 times were 5.3 months and 10.3 months, respectively. Overall, although GFP resulted in acceptable response and survival rates, it does not appear to have marked superiority to @entity2 -based single or duplet chemotherapy.

title: Triplet cytotoxic chemotherapy with XXXX , @entity10 and @entity6 for advanced @entity4 .

answer: @entity2


abstract: UNASSIGNED: The chemokine system has been reported to be utilized and manipulated by @entity3 cells in order to promote @entity3 growth and distant dissemination. The present study aimed to investigate the expression of three chemokine ligand-receptor axes in @entity1 tissues. @entity3 and healthy normal tissue samples were obtained from 120 @entity1 @entity0 following surgical resection. Immunohistochemistry and reverse transcription quantitative polymerase chain reaction were used in order to identify the protein and messenger (m)RNA expression of chemokines, including chemokine (C-X-C motif) ligand (CXCL)12/stromal cell-derived factor (SDF)-1, @entity6 , chemokine ( @entity12 and @entity8 , and the corresponding chemokine receptors, chemokine ( @entity5 , @entity9 , @entity10 and chemokine ( @entity11 , respectively. The results revealed that compared with the normal lung tissues, @entity1 tissues expressed significantly higher mRNA levels of @entity7 / @entity7 , @entity5 , @entity6 / @entity6 , @entity10 , @entity12 and @entity11 (P<0.01). In four histological subtypes, @entity4 presented dominant expression of @entity5 , @entity10 , @entity6 / @entity6 and @entity12 (P<0.05). In addition, it was demonstrated that @entity3 staging was inversely correlated with @entity5 @entity11 and @entity10 mRNA expression as well as positively correlated with @entity7 / @entity7 , @entity6 / @entity6 and @entity12 mRNA levels (P<0.05). Lymph node @entity2 presented a positive correlation with @entity5 , @entity10 and @entity6 / @entity6 expression and a negative correlation with @entity12 and @entity11 expression (P<0.05). Furthermore, vascular invasion was more prevalent in @entity0 with higher expression levels of @entity5 , @entity11 or @entity12 (P<0.01). In conclusion, these data suggested that the ligand-receptor interaction of @entity13 , @entity7 - @entity5 and @entity14 may be involved in the tumorigenesis of @entity1 . Higher expression levels of chemokines and lower expression of chemokine receptors indicated poor @entity3 staging. The CXC chemokine receptors, @entity5 and @entity10 , promoted lymphatic @entity2 through the activation of their specific ligands, while @entity12 and its receptor @entity11 had an essential role in hematogenous @entity1 .

title: Association of chemokine and @entity5 expression with the invasion and XXXX .

answer: @entity1


abstract: UNASSIGNED: The chemokine system has been reported to be utilized and manipulated by @entity3 cells in order to promote @entity3 growth and distant dissemination. The present study aimed to investigate the expression of three chemokine ligand-receptor axes in @entity1 tissues. @entity3 and healthy normal tissue samples were obtained from 120 @entity1 @entity0 following surgical resection. Immunohistochemistry and reverse transcription quantitative polymerase chain reaction were used in order to identify the protein and messenger (m)RNA expression of chemokines, including chemokine (C-X-C motif) ligand (CXCL)12/stromal cell-derived factor (SDF)-1, @entity6 , chemokine ( @entity12 and @entity8 , and the corresponding chemokine receptors, chemokine ( @entity5 , @entity9 , @entity10 and chemokine ( @entity11 , respectively. The results revealed that compared with the normal lung tissues, @entity1 tissues expressed significantly higher mRNA levels of @entity7 / @entity7 , @entity5 , @entity6 / @entity6 , @entity10 , @entity12 and @entity11 (P<0.01). In four histological subtypes, @entity4 presented dominant expression of @entity5 , @entity10 , @entity6 / @entity6 and @entity12 (P<0.05). In addition, it was demonstrated that @entity3 staging was inversely correlated with @entity5 @entity11 and @entity10 mRNA expression as well as positively correlated with @entity7 / @entity7 , @entity6 / @entity6 and @entity12 mRNA levels (P<0.05). Lymph node @entity2 presented a positive correlation with @entity5 , @entity10 and @entity6 / @entity6 expression and a negative correlation with @entity12 and @entity11 expression (P<0.05). Furthermore, vascular invasion was more prevalent in @entity0 with higher expression levels of @entity5 , @entity11 or @entity12 (P<0.01). In conclusion, these data suggested that the ligand-receptor interaction of @entity13 , @entity7 - @entity5 and @entity14 may be involved in the tumorigenesis of @entity1 . Higher expression levels of chemokines and lower expression of chemokine receptors indicated poor @entity3 staging. The CXC chemokine receptors, @entity5 and @entity10 , promoted lymphatic @entity2 through the activation of their specific ligands, while @entity12 and its receptor @entity11 had an essential role in hematogenous @entity1 .

title: Association of chemokine and XXXX expression with the invasion and @entity1 .

answer: @entity5