abstract: OBJECTIVE: @entity4 ( @entity4 ) is associated with high cardiovascular risk. @entity1 ( @entity1 ) are common on brain magnetic resonance imaging (MRI) in @entity0 with increased cardiovascular risk. AIM: To investigate the relationship between cardiovascular risk, @entity1 , neuropsychological performance and brain volume in @entity4 . DESIGN/METHODS: Thirty-eight @entity0 with @entity4 (23 in remission, 15 active) and 38 controls sex-, age- and education-level matched underwent a neuropsychological and clinical evaluation, blood and urine tests and 3Tesla brain MRI. @entity1 were analysed with the Scheltens scale. Ten-year cardiovascular risk (10CVR) and @entity3 ( @entity3 ) were calculated according to an algorithm based on the Framingham heart study. RESULTS: @entity0 in remission had a higher degree of @entity1 than controls and active @entity0 (P<0.001 and P=0.008 respectively), which did not correlate with cognitive performance in any group. @entity1 severity positively correlated with diastolic blood pressure (r=0.659, P=0.001) and duration of @entity2 (r=0.478, P=0.021) in @entity0 in remission.   Both @entity0 groups (active and in remission) had higher 10CVR (P=0.030, P=0.041) and @entity3 than controls (P=0.013, P=0.039). Neither the 10CVR nor the @entity3 correlated with @entity1 , although both negatively correlated with cognitive function and brain volume in @entity0 in remission (P<0.05).   Total brain volume and grey matter volume in both @entity4 @entity0 groups were reduced compared to controls (total volume: active P=0.006, in remission P=0.012; grey matter: active P=0.001, in remission P=0.003), with no differences in white matter volume between groups. CONCLUSIONS: @entity0 in remission of @entity4 (but not active @entity0 ) have more severe @entity1 than controls, positively correlated with diastolic pressure and duration of @entity2 . Ten-year cardiovascular risk and @entity3 appear to be negatively correlated with the cognitive function and brain volume in @entity0 in remission of @entity4 .

title: Cardiovascular risk and @entity1 after endocrine control of XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity4 ) of salivary glands are rare @entity2 that mostly affect the major salivary glands. They are generally considered @entity3 that are locally destruc.tive and tend to recur, but only occasionally metastasize. Currently there are only a few reported cases of distant metastases from BCAC, and @entity1 to the liver is not previously described. We report the first case of BCAC with histologically confirmed liver metastases. A 40-year-old @entity0 presented with a 2-month history of a painless swelling in the left buccal region. The lesion was completely resected, and the @entity0 underwent postoperative radiotherapy. Permanent histology and immunohistochemical studies revealed a BCAC of the buccal minor salivary gland. After 14 months, two hepatic metastatic nodules were detected. The @entity0 underwent a partial hepatectomy with adjuvant chemotherapy. No evidence of progressive disease or further recurrence was observed for 20 months after the hepatic metastasectomy. @entity4 grow indolently and long-term survival can be expected. Surgery should be considered in selected @entity0 as a therapeutic option in metastatic disease.

title: XXXX of the buccal minor salivary gland with liver metastases.

answer: @entity4


abstract: PURPOSE: @entity2 ( @entity2 ) are common and frequently occur after @entity1 . They significantly impair visual function and cause disability particularly with regard to visual exploration. The purpose of this study was to assess a novel interventional treatment of monocular prism therapy on visual functioning in @entity0 with @entity2 of varied etiology using vision targeted, health-related quality of life (QOL) questionnaires. Our secondary aim was to confirm monocular and binocular visual field expansion pre- and posttreatment. METHODS: Twelve @entity0 with acquired, documented @entity2 were eligible to be included. All @entity0 underwent specific vision-targeted, health-related QOL questionnaire and monocular and binocular Goldmann perimetry before commencing prism therapy. @entity0 were fitted with monocular prisms on the side of the @entity2 with the base-in the direction of the field defect creating a peripheral optical exotropia and field expansion. After the treatment period, QOL questionnaires and perimetry were repeated. RESULTS: Twelve @entity0 were included in the treatment group, 10 of whom were included in data analysis. Overall, there was significant improvement within multiple vision-related, QOL functioning parameters, specifically within the domains of general health (p < 0.01), general vision (p < 0.05), distance vision (p < 0.01), peripheral vision (p < 0.05), role difficulties (p < 0.05), dependency (p < 0.05), and social functioning (p < 0.05). Visual field expansion was shown when measured monocularly and binocularly during the study period in comparison with pretreatment baselines. CONCLUSIONS: @entity0 with @entity2 demonstrate decreased QOL. Monocular sector prisms can improve the QOL and expand the visual field in these @entity0 .

title: Prism therapy and visual rehabilitation in homonymous XXXX .

answer: @entity2


abstract: UNASSIGNED: Cancer stem cells (CSCs) are key cellular targets for effective @entity0 therapy, due to their critical roles in @entity0 progression and chemo/radio-resistance. Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) are important players in the biology of @entity0 . However, it remains unknown whether lncRNAs could be exploited to target CSCs. We report that large intergenic non-coding RNA @entity4 ( @entity5 ) is a potent suppressor of stem-like traits of CSCs purified from both primary @entity1 ( @entity1 ) tissues and cell lines. A novel @entity5 -expressing adenoviral vector, which was armed with miRNA responsive element (MRE) of @entity3 (Ad-lnc- @entity4 -MRE), was generated to eliminate @entity1 CSCs. Integration of @entity3 MREs into the adenovirus efficiently delivered @entity5 into CSCs that contained low levels of @entity3 . Moreover, @entity5 inhibited the activity of b-catenin signaling, thereby attenuating the viability, self-renewal, and glycolysis of CSCs in vitro. By limiting dilution and serial @entity0 formation assay, we demonstrated that Ad-lnc- @entity4 -MRE significantly suppressed the self-renewal potential and tumorigenicity of CSCs in @entity2 . Importantly, application of @entity3 MREs appeared to protect normal liver cells from off-target expression of @entity5 in both @entity0 -bearing and na  ve @entity2 . Taken together, these findings suggest that lncRNAs may be promising therapeutic molecules to eradicate CSCs and @entity0 -suppressor miRNAs, such as @entity3 , may be exploited to ensure the specificity of CSC-targeting strategies.

title: miRNA-regulated delivery of XXXX suppresses b-catenin signaling and tumorigenicity of @entity1 stem cells.

answer: @entity5


abstract: UNASSIGNED: Cancer stem cells (CSCs) are key cellular targets for effective @entity0 therapy, due to their critical roles in @entity0 progression and chemo/radio-resistance. Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) are important players in the biology of @entity0 . However, it remains unknown whether lncRNAs could be exploited to target CSCs. We report that large intergenic non-coding RNA @entity4 ( @entity5 ) is a potent suppressor of stem-like traits of CSCs purified from both primary @entity1 ( @entity1 ) tissues and cell lines. A novel @entity5 -expressing adenoviral vector, which was armed with miRNA responsive element (MRE) of @entity3 (Ad-lnc- @entity4 -MRE), was generated to eliminate @entity1 CSCs. Integration of @entity3 MREs into the adenovirus efficiently delivered @entity5 into CSCs that contained low levels of @entity3 . Moreover, @entity5 inhibited the activity of b-catenin signaling, thereby attenuating the viability, self-renewal, and glycolysis of CSCs in vitro. By limiting dilution and serial @entity0 formation assay, we demonstrated that Ad-lnc- @entity4 -MRE significantly suppressed the self-renewal potential and tumorigenicity of CSCs in @entity2 . Importantly, application of @entity3 MREs appeared to protect normal liver cells from off-target expression of @entity5 in both @entity0 -bearing and na  ve @entity2 . Taken together, these findings suggest that lncRNAs may be promising therapeutic molecules to eradicate CSCs and @entity0 -suppressor miRNAs, such as @entity3 , may be exploited to ensure the specificity of CSC-targeting strategies.

title: miRNA-regulated delivery of @entity5 suppresses b-catenin signaling and tumorigenicity of XXXX stem cells.

answer: @entity1


abstract: UNASSIGNED: We have previously reported two trials in @entity4 ( @entity4 ) evaluating vaccine therapy with the telomerase peptide GV1001. The studies demonstrated considerable differences in survival among immune responders, highlighting that an immune response is not necessarily beneficial. In the present study, we conducted long-term clinical follow-up and investigated immunological factors hypothesized to influence clinical efficacy. Peripheral blood mononuclear cells from 33 @entity4 trial @entity0 and 15 healthy donors were analyzed by flow cytometry for T regulatory cells (Tregs, CD4(+) @entity5 (+)CD127(low/-)FOXP3(+)) and two types of myeloid-derived suppressor cells (MDSCs, HLA-DR (low) @entity7 (+) or Lin (-/lo) HLA-DR (-) @entity3 (+) @entity8 (+)). T cell cultures were analyzed for 17 cytokines. The results demonstrated that immune responders had increased overall survival (OS, p  <  0.001) and progression-free survival (p  =  0.003), compared to subjects without immunological response. The mean OS advantage was 54 versus 13  months. Six @entity0 were still alive at the last clinical update, all belonging to the immune responders. No serious @entity1 had developed (maximum observation 13  years). Most @entity0 developed a polyfunctional cytokine profile, with high IFNy/ @entity6 and IFNy/ @entity2 ratios. Low Treg levels were associated with improved OS (p  =  0.037) and a favorable cytokine profile, including higher IFNy/ @entity2 ratios. High @entity3 (+) MDSC levels were associated with poorer immune response rate (p  =  0.005). The levels of @entity7 (+) MDSC were significantly higher in @entity0 than in healthy controls (p  =  0.012). We conclude that a randomized GV1001 trial in @entity4 is warranted. The findings suggest that Tregs and MDSCs are associated with a tolerogenic cytokine milieu and impaired clinical efficacy of vaccine responses.

title: Immunological factors influencing clinical outcome in lung cancer XXXX after telomerase peptide vaccination.

answer: @entity0


abstract: The St. John's Wort (Hypericum perforatum) extract (Hp) represents one of the most useful natural therapeutic agents in the treatment of moderate and mild @entity1 . The antidepressant effects of Hp are different, by a molecular mechanism point of view, when compared to those of other antidepressant drugs and, we think, a further pharmacological characterization is needed. It is suggested that the neurochemical effects of Hp could be bind either to its activity on the uptake of some mediators in the central nervous system or to the inhibition of some enzymatic activity at the receptor level. The present study carried out with the loose patch clamp (LPC) in the @entity0 neuromuscular junction, indicates a potentiation of the @entity2 ( @entity3 ) action at the @entity0 neuromuscular junction. The spontaneous release of @entity3 was unaffected by Hp indicating that neither presynaptic nor postsynaptic function are modified by Hp. Indeed, both the frequency and the amplitude of the miniature end-plate currents (mepcs) were unmodified by Hp. Furthermore, the mepcs decay time (tau), i.e. the apparent cholinergic channel life time, was significantly increased after Hp treatment. The other parameter affected was the amplitude of the evoked end-plate currents (epcs) which was constantly and in a dose dependent manner increased by Hp. These findings suggest a possible action of Hp on the @entity4 ( @entity4 ) in terms of a reduction of the degradation rate of @entity3 .

title: Effects of Hypericum extract on the XXXX release: a loose patch clamp approach.

answer: @entity2


abstract: PURPOSE: To describe the characteristic features of @entity1 associated with granular @entity4 (GCD2). METHODS: Five @entity0 with GCD2 associated with the @entity5 mutation (2 homozygous GCD2 and 3 heterozygotes) were examined. The @entity3 of all @entity0 were assessed and reviewed by slit-lamp photographs. Density line profiles of corneal surfaces were evaluated around the discrete @entity3 using Image J software. A Fourier-domain optical coherence tomography with @entity2 anterior module was used to visualize the characteristic surrounding features of these granular deposits. A histopathological study of the homozygous corneal specimen obtained after keratoplasty was performed. RESULTS: Slit-lamp images and densitometry line profiles showed that discrete granules were surrounded by relatively clear areas in all @entity0 . The Fourier-domain optical coherence tomography image clearly showed highly reflective lesions, corresponding to the @entity3 , surrounded by lower reflective areas. Histopathological study revealed comparable findings to the optical coherence tomography image. Serial comparison of slit-lamp photographs demonstrated a recurrence pattern after penetrating keratoplasty in a homozygous @entity0 and natural progression in a heterozygote @entity0 . They were similar in that diffuse fine granules gradually increased in density and discrete granular deposits also enlarged or were newly formed. CONCLUSIONS: In GCD2, discrete @entity1 were surrounded by rather lucid areas and fine granular haze. These findings suggest that @entity1 may be formed by aggregation of surrounding fine granules.

title: Characteristic features of granular deposit formation in granular XXXX .

answer: @entity4


abstract: Phagostimulatory effects of pH values of @entity1 on Rhagoletis pomonella adults were studied in the laboratory. Flies were standardized for age, diet and food deprivation. Two presentation schemes were employed. The first varied pH value (3.0-10.0) with @entity1 concentration kept constant at 40%. The second varied both @entity1 concentration (8%, 24% and 40%) and pH value (5.0-8.0). @entity0 feeding propensity was evaluated by observation of @entity0 acceptance or rejection of @entity1 and duration of feeding. When tested on red wooden spheres treated with 40% @entity1 , @entity0 feeding acceptance was significantly greater when pH ranged from 5.0 to 8.0, and duration of feeding was significantly longer at pH 6.0-7.0. At pH </=4.0 or pH >/=8.0, feeding propensity was significantly reduced. Decrease in @entity1 concentration significantly increased @entity0 sensitivity to pH. Males were more responsive to varying pH than females. The @entity1 pH shown to stimulate maximal feeding response was 6.4. Such information is relevant to formulation improvement of a coating mixture of @entity1 and insecticide applied to red spheres as part of apple maggot @entity0 control programs.

title: Effects of pH on feeding responses in the apple maggot XXXX , Rhagoletis pomonella (Diptera: Tephritidae).

answer: @entity0


abstract: UNASSIGNED: The aim of this study was to demonstrate the variations in bioavailability remaining in industrial and agricultural soils contaminated by @entity0 ( @entity1 ) after bioremediation. After inoculation of Mycobacterium sp. and Mucor sp., @entity1 biodegradation was tested on a manufactured gas plant (MGP) soil and an agricultural soil. @entity1 bioavailability was assessed before and after biodegradation using solid-phase extraction (Tenax-TA extraction) and solid-phase micro-extraction (SPME) to represent bioaccessibility and chemical activity of @entity1 , respectively. Only 3- and 4-ring @entity1 were noticeably biodegradable in the MGP soil. @entity1 biodegradation in the agricultural soil was different from that in the MGP soil. The rapidly desorbing fractions ( @entity2 ) extracted by Tenax-TA and the freely dissolved concentrations of 3- and 4-ring @entity1 determined by SPME from the MGP soil decreased after 30 days biodegradation; those values of the 5- and 6-ring @entity1 changed to a lesser degree. For the agricultural soil, the @entity2 values of the 3- and 4-ring @entity1 also decreased after the biodegradation experiment. The Tenax-TA extraction and the SPME have the potential to assess variations in the bioavailability of @entity1 and the degree of biodegradation in contaminated MGP soils. In addition, Tenax-TA extraction is more sensitive than SPME when used in the agricultural soil.

title: Variations in the bioavailability of XXXX in industrial and agricultural soils after bioremediation.

answer: @entity0


abstract: German cockroaches @entity4 (L.) are gregarious insects. An aggregation @entity2 contributes to the maintenance of aggregates. Choice experiments checked the efficiency of different solvents, i.e. @entity1 , @entity0 and @entity5 , in extracting attractive substances and compared the attractiveness of extracts of different parts of the body. @entity1 and @entity5 were the most efficient solvents tested for extracting the attractive substances. @entity0 whole body extracts appeared inefficient to induce aggregation. The proportion of larvae attracted to conditioned papers decreased in relation to the size of cuticular surface washed, from whole body to half-body and again to a section of the body cut in three. Attractive substances appear to be present on all parts of the body. Chemical analysis by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) showed that the active extracts contained only cuticular @entity3 . In addition to behavioural tests, differences between the composition of @entity0 extracts and that of the extracts for the other two solvents were revealed by GC. These results indicated that the cuticular hydrocarbons operate as an aggregation pheromone in @entity4 .

title: Cuticular extracts inducing aggregation in the XXXX , @entity4 (L.).

answer: @entity4


abstract: German cockroaches @entity4 (L.) are gregarious insects. An aggregation @entity2 contributes to the maintenance of aggregates. Choice experiments checked the efficiency of different solvents, i.e. @entity1 , @entity0 and @entity5 , in extracting attractive substances and compared the attractiveness of extracts of different parts of the body. @entity1 and @entity5 were the most efficient solvents tested for extracting the attractive substances. @entity0 whole body extracts appeared inefficient to induce aggregation. The proportion of larvae attracted to conditioned papers decreased in relation to the size of cuticular surface washed, from whole body to half-body and again to a section of the body cut in three. Attractive substances appear to be present on all parts of the body. Chemical analysis by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) showed that the active extracts contained only cuticular @entity3 . In addition to behavioural tests, differences between the composition of @entity0 extracts and that of the extracts for the other two solvents were revealed by GC. These results indicated that the cuticular hydrocarbons operate as an aggregation pheromone in @entity4 .

title: Cuticular extracts inducing aggregation in the @entity4 , XXXX (L.).

answer: @entity4


abstract: AIMS: Lead @entity1 in @entity2 ( @entity2 ) @entity0 may cause inappropriate shocks (ISs). An early diagnosis is essential to prevent adverse clinical events. Implantable cardioverter-defibrillator remote monitoring (RM) permits prompt detection of lead @entity1 . Limited data define the impact of RM on ISs specifically related to lead @entity1 . We sought to compare the number of ISs related to lead @entity1 in @entity0 with vs. without RM follow-up. METHODS AND RESULTS: We checked the registry of our institution and collected, between July 2007 and June 2014, 115 cases of right @entity1 . All relevant data were documented from @entity0 ' files, device-interrogation printouts and electronic records, and remote transmissions databases when applicable. We assessed the ISs that were related to lead @entity1 . The first study endpoint was the number of ISs per shocked @entity0 . Among the 82 @entity0 with conventional follow-up (CFU) and the 33 @entity0 with RM, a first IS occurred to 32.9% (n = 27) and 30.3% (n = 10, P = 0.83) of the @entity0 , respectively. Shocked @entity0 in the RM group underwent significantly fewer ISs with a mean of 6    2 shocks per @entity0 [median of 3.5 shocks (2-8)] than those in the CFU group with a mean of 18    5 shocks per @entity0 [median of 10 shocks (5-22), P = 0.03]. CONCLUSION: Remote monitoring helps to reduce the burden of ISs related to @entity2 lead @entity1 .

title: Impact of remote monitoring on reducing the burden of inappropriate shocks related to implantable XXXX : insights from a French single-centre registry.

answer: @entity1


abstract: BACKGROUND: To study the rules that apparent diffusion coefficient (ADC) changes with time and space in @entity1 , and to provide the evidence in defining the @entity2 stages. METHODS: 117 work-ups in 98 @entity0 with @entity1 (12 hyperacute, 43 acute, 29 subacute, 10 steady, and 23 chronic @entity2 ) were imaged with both conventional MRI and diffusion weighted imaging. The average ADC values, the relative ADC (rADC) values, and the ADC values or rADC values from the center to the periphery of the lesion were calculated. RESULTS: The average ADC values and the rADC values of hyperacute and acute @entity3 depressed obviously. rADC values in hyperacute and acute stage was minimized, and increased progressively as time passed and appeared as "pseudonormal" values in approximately 8 to 14 days. Thereafter, rADC values became greater than normal in chronic stage. There was positive correlation between rADC values and time (P < 0.01). The ADC values and the rADC values in hyperacute and acute lesions had gradient signs that these lesions increased from the center to the periphery. The ADC values and the rADC values in subacute lesions had adverse gradient signs that these lesions decreased from the center to the periphery. CONCLUSION: The ADC values of @entity2 lesions have evolution rules with time and space. The evolution rules with time and those in space can be helpful to decide the clinical stage, and to provide the evidence in guiding the treatment or judging the prognosis in @entity2 .

title: The use of MRI apparent diffusion coefficient (ADC) in monitoring the development of XXXX .

answer: @entity3


abstract: UNASSIGNED: BACKGROUND Retention of surgical items after a surgical procedure is not only a medical error, but can also lead to various unexpected complications and additional surgery procedures even years after the initial operation. CASE REPORT A 59-year old @entity0 was referred to our hospital with intermittent @entity3 in the lesser pelvis for about three months. She had undergone laparotomy for cholecystectomy 24 years ago and adnexectomy more than 30 years ago. CT-scan and MRI indicated a @entity1 , most likely compatible with a @entity2 . A laparoscopic resection of the @entity1 was performed. Intraoperatively the @entity1 showed no clear capsule and could only be resected by fragments. The pathological report analyzed textile fibres, diagnosing a textiloma. The @entity0 showed an uneventful postoperative follow-up. CONCLUSIONS Most likely, the textile fibres originated from a sponge, which was retained during adnexectomy 33 years ago. There are numerous reports of retained surgical items discovered years after the initial operation. In literature, there are several reported cases of transmural migration of a sponge into the intestine, stomach and bladder. In our case, the sponge must have migrated to the deepest point of the retroperitoneum, which appears to be quite unusual, as no comparable case reports could be found. This case stresses the importance of the surgeon's awareness to particular appearances of a retained surgical sponge from a surgical procedure performed even decades ago. Additionally, this case report stresses the importance of meticulous analysis of individual @entity0 medical history.

title: Atypical Case of a Painful XXXX .

answer: @entity1


abstract: The economic impact of @entity2 infections has led a number of countries in Europe to start eradication or control programmes. While in both cases the primary step is identification and elimination of persistently infected (PI) animals, the strategy applied thereafter is dependent on the density and seroprevalence of the regional @entity0 population. One of the first countries to design and implement an eradication programme was Sweden in 1993, a country with a relatively low @entity0 density and no vaccination. For screening, an indirect antibody ELISA for serum, milk and bulk milk samples is being used. The basics of the Swedish model are no vaccination, @entity1 , and financing of the entire scheme by the subscribing farmers. @entity2 -free herds are certified and permanently checked. While in 1993 only about 35% of the herds were seronegative, about 87% were @entity2 -free in 2001. The aim of control programmes in high density areas with high seroprevalence is to minimize economic losses by reducing the incidence of PI animals and thereby virus circulation (German model). Participation is voluntary, and parts of the costs are carried by the public animal insurance (Tierseuchenkasse). Screening is performed using an antigen capture ELISA with blood or serum. In Lower Saxony, for example, a herd is declared @entity2 unsuspicious if all animals up to 36 months are BVDV antigen negative and the female offspring older than six months is vaccinated twice (an inactivated vaccine is used for basic immunization, and an attenuated live virus vaccine for boosting).

title: XXXX viral diarrhoea eradication and control programmes in Europe.

answer: @entity0


abstract: Pyramidal cells receive input from several types of @entity3 -releasing interneurons and innervate them reciprocally. Glutamatergic activation of interneurons involves both @entity0 ( @entity0 ) and @entity2 ( @entity1 ) type @entity5 receptors expressed in type I synapses, mostly on their dendritic shafts. On average, the synaptic @entity0 receptor content is several times higher on interneurons than in the spines of pyramidal cells. To compare the @entity1 receptor content of synapses, we used a quantitative postembedding immunogold technique on serial electron microscopic sections, and analysed the synapses on interneuron dendrites and pyramidal cell spines in the @entity4 area. Because all @entity1 receptors contain the obligatory @entity6 subunit, receptor localisation was carried out using antibodies recognising all splice variants of the @entity6 subunit. Four populations of synapse were examined: i). on spines of pyramidal cells in stratum (str.) radiatum and str. oriens; ii). on @entity7 -positive interneuronal dendritic shafts in str. radiatum; iii). on randomly found dendritic shafts in str. oriens and iv). on somatostatin-positive interneuronal dendritic shafts and somata in str. oriens. On average, the size of the synapses on spines was about half of those on interneurons. The four populations of synapse significantly differed in labelling for the @entity6 subunit. The median density of @entity6 subunit labelling was highest on pyramidal cell spines. It was lowest in the synapses on @entity7 -positive dendrites in str. radiatum, where more than half of these synapses were immunonegative. In str. oriens, synapses on interneurons had a high variability of receptor content; some dendrites were similar to those in str. radiatum, including the proximal synapses of somatostatin-positive cells, whereas others had immunoreactivity for the @entity6 subunit similar to or higher than synapses on pyramidal cell spines. These results show that synaptic @entity1 receptor density differs between pyramidal cells and interneurons. Some interneurons may have a high @entity1 receptor content, whereas others, like some @entity7 -expressing cells, a particularly low synaptic @entity1 receptor content. Consequently, fast glutamatergic activation of interneurons is expected to show cell type-specific time course and state-dependent dynamics.

title: Large variability in synaptic XXXX receptor density on interneurons and a comparison with pyramidal-cell spines in the rat hippocampus.

answer: @entity2


abstract: OBJECTIVE: To find out the features of glycemic excursion via continuous @entity2 monitoring system (CGMS) during continuous subcutaneous @entity3 infusion (CSII) treatment in type 2 @entity1 and discuss the possibility of predicting @entity6 with bedtime @entity2 level. METHODS: A total of 257 @entity1 @entity0 (156 males and 101 females, aged from 27 - 88 years old) with 0.1 - 40 years diabetic history were recruited. Their HbA1c level was (10.97    2.11)%. Glycated albumin level was (31.88    7.51)%. All @entity0 were switched to CSII therapy while a 72-hour period of CGMS was performed. @entity0 were divided into @entity4 group and non- @entity4 group according to the reading of hypoglycemic events from CGMS data. RESULTS: (1) From CGMS profiles, the investigators found that @entity5 was (9.66    2.00) mmol/L and SDBG (2.98    1.03) mmol/L. (2) A total of 243 @entity4 events occurred in 118 @entity0 at early stage of CSII treatment. (3) When bedtime blood @entity2 was below 5.9 mmol/L, the youden index was maximal on a receiver operating characteristic curve. The sensitive was 54.8% and specificity 77.8%. Positive predictive value was 44.3% and negative predictive value 84.2%. So the cut-off point of bedtime blood @entity2 to predict @entity4 might be 5.9 mmol/L. CONCLUSION: (1) @entity4 as detected by CGMS occurs in almost 1/2 type 2 @entity1 during CSII therapy. (2) There is a higher risk of @entity4 if the bedtime blood @entity2 concentration falls below 5.9 mmol/L.

title: [Prediction of @entity6 with bedtime XXXX level during continuous subcutaneous @entity3 infusion in type 2 @entity1 ].

answer: @entity2


abstract: OBJECTIVE: To find out the features of glycemic excursion via continuous @entity2 monitoring system (CGMS) during continuous subcutaneous @entity3 infusion (CSII) treatment in type 2 @entity1 and discuss the possibility of predicting @entity6 with bedtime @entity2 level. METHODS: A total of 257 @entity1 @entity0 (156 males and 101 females, aged from 27 - 88 years old) with 0.1 - 40 years diabetic history were recruited. Their HbA1c level was (10.97    2.11)%. Glycated albumin level was (31.88    7.51)%. All @entity0 were switched to CSII therapy while a 72-hour period of CGMS was performed. @entity0 were divided into @entity4 group and non- @entity4 group according to the reading of hypoglycemic events from CGMS data. RESULTS: (1) From CGMS profiles, the investigators found that @entity5 was (9.66    2.00) mmol/L and SDBG (2.98    1.03) mmol/L. (2) A total of 243 @entity4 events occurred in 118 @entity0 at early stage of CSII treatment. (3) When bedtime blood @entity2 was below 5.9 mmol/L, the youden index was maximal on a receiver operating characteristic curve. The sensitive was 54.8% and specificity 77.8%. Positive predictive value was 44.3% and negative predictive value 84.2%. So the cut-off point of bedtime blood @entity2 to predict @entity4 might be 5.9 mmol/L. CONCLUSION: (1) @entity4 as detected by CGMS occurs in almost 1/2 type 2 @entity1 during CSII therapy. (2) There is a higher risk of @entity4 if the bedtime blood @entity2 concentration falls below 5.9 mmol/L.

title: [Prediction of XXXX with bedtime @entity2 level during continuous subcutaneous @entity3 infusion in type 2 @entity1 ].

answer: @entity6


abstract: OBJECTIVE: To find out the features of glycemic excursion via continuous @entity2 monitoring system (CGMS) during continuous subcutaneous @entity3 infusion (CSII) treatment in type 2 @entity1 and discuss the possibility of predicting @entity6 with bedtime @entity2 level. METHODS: A total of 257 @entity1 @entity0 (156 males and 101 females, aged from 27 - 88 years old) with 0.1 - 40 years diabetic history were recruited. Their HbA1c level was (10.97    2.11)%. Glycated albumin level was (31.88    7.51)%. All @entity0 were switched to CSII therapy while a 72-hour period of CGMS was performed. @entity0 were divided into @entity4 group and non- @entity4 group according to the reading of hypoglycemic events from CGMS data. RESULTS: (1) From CGMS profiles, the investigators found that @entity5 was (9.66    2.00) mmol/L and SDBG (2.98    1.03) mmol/L. (2) A total of 243 @entity4 events occurred in 118 @entity0 at early stage of CSII treatment. (3) When bedtime blood @entity2 was below 5.9 mmol/L, the youden index was maximal on a receiver operating characteristic curve. The sensitive was 54.8% and specificity 77.8%. Positive predictive value was 44.3% and negative predictive value 84.2%. So the cut-off point of bedtime blood @entity2 to predict @entity4 might be 5.9 mmol/L. CONCLUSION: (1) @entity4 as detected by CGMS occurs in almost 1/2 type 2 @entity1 during CSII therapy. (2) There is a higher risk of @entity4 if the bedtime blood @entity2 concentration falls below 5.9 mmol/L.

title: [Prediction of @entity6 with bedtime @entity2 level during continuous subcutaneous @entity3 infusion in type 2 XXXX ].

answer: @entity1


abstract: OBJECTIVE: To find out the features of glycemic excursion via continuous @entity2 monitoring system (CGMS) during continuous subcutaneous @entity3 infusion (CSII) treatment in type 2 @entity1 and discuss the possibility of predicting @entity6 with bedtime @entity2 level. METHODS: A total of 257 @entity1 @entity0 (156 males and 101 females, aged from 27 - 88 years old) with 0.1 - 40 years diabetic history were recruited. Their HbA1c level was (10.97    2.11)%. Glycated albumin level was (31.88    7.51)%. All @entity0 were switched to CSII therapy while a 72-hour period of CGMS was performed. @entity0 were divided into @entity4 group and non- @entity4 group according to the reading of hypoglycemic events from CGMS data. RESULTS: (1) From CGMS profiles, the investigators found that @entity5 was (9.66    2.00) mmol/L and SDBG (2.98    1.03) mmol/L. (2) A total of 243 @entity4 events occurred in 118 @entity0 at early stage of CSII treatment. (3) When bedtime blood @entity2 was below 5.9 mmol/L, the youden index was maximal on a receiver operating characteristic curve. The sensitive was 54.8% and specificity 77.8%. Positive predictive value was 44.3% and negative predictive value 84.2%. So the cut-off point of bedtime blood @entity2 to predict @entity4 might be 5.9 mmol/L. CONCLUSION: (1) @entity4 as detected by CGMS occurs in almost 1/2 type 2 @entity1 during CSII therapy. (2) There is a higher risk of @entity4 if the bedtime blood @entity2 concentration falls below 5.9 mmol/L.

title: [Prediction of @entity6 with bedtime @entity2 level during continuous subcutaneous XXXX infusion in type 2 @entity1 ].

answer: @entity3


abstract: Primary @entity5 are rare @entity1 comprising two percent of all @entity7 . Although a treatment guideline has yet to be established, maximal surgical resection is primary in the treatment of @entity5 . Adjuvant radiotherapy has remained controversial, and it is unclear whether chemotherapy adds any benefit. In this case report, the authors present a 24-year-old male who had a seven-year history of @entity4 and a radiating @entity3 in both legs. Magnetic resonance image (MRI) showed an intramedullary mass at the T4-T8 level. He underwent subtotal @entity1 and pathologic diagnosis revealed a WHO grade II @entity6 . The @entity0 was treated with radiotherapy postoperatively and followed up with MRI annually. Clinical and radiological status of the @entity0 had been stationary for four years after the surgery. The five-year follow-up MRI showed an increase in the size and extent of the @entity2 . Despite radiological progression, considering that symptoms and the performance status of the @entity0 had remained unchanged, further treatment has not been performed. Given the clinical outcome of this @entity0 , close observation after subtotal removal with adjuvant radiotherapy is one of the acceptable treatment options for WHO grade II @entity5 .

title: Primary XXXX with Postoperative Adjuvant Radiotherapy: A Case Report.

answer: @entity5


abstract: PURPOSE: A major problem that urologists encounter is the recurrence of @entity1 after local therapy or the failure of primary therapy. There is no consensus on the treatment of these groups of @entity0 . The role of radiotherapy, hormonal therapy or chemotherapy must be defined. MATERIALS AND METHODS: A comprehensive literature review of the current management of recurrence after primary therapy in @entity1 was performed using MEDLINE, a review of current urology and oncology journals, and abstracts from recent urology meetings. The data collected focused on the role of radiotherapy, hormonal therapy and chemotherapy in this setting. RESULTS: Defining a high risk group of @entity0 using Gleason score, seminal vesicle or pelvic lymph node involvement and @entity3 recurrence time is important for treating the problem early in disease course. Adjuvant radiotherapy cannot offer a survival advantage but it provides longer biochemical recurrence-free survival. Early administration of salvage radiotherapy in adequate doses provides a success rate similar to that of adjuvant radiotherapy in @entity0 with low @entity3 . Although there is no good evidence that early @entity2 deprivation definitely prolongs @entity0 survival, increased time to progression in addition to excellent palliation with early hormonal therapy was reported in the majority of trials. Early trials of the use of chemotherapy showed improved survival rates with adjuvant chemotherapy alone or with a combination of hormonal therapy, especially in @entity0 with nonmetastatic disease. CONCLUSIONS: Although analysis of current literature revealed that @entity0 who have recurrence after primary therapy would benefit from radiotherapy, hormonal therapy, chemotherapy or a combination of therapies, additional prospective randomized studies are needed to support these findings.

title: The management of high risk XXXX .

answer: @entity1


abstract: PURPOSE: Previous studies have shown that early intracavernous @entity1 injection may reduce significantly the incidence of @entity2 before spontaneous erections recover after nerve sparing radical prostatectomy. We identify the more convenient postoperative timing for successful intracavernous injection rehabilitation in a series of @entity0 who underwent nonnerve sparing radical prostatectomy. MATERIALS AND METHODS: A total of 73 @entity0 with a normal preoperative International Index of Erectile Function score were randomly allocated to undergo dynamic color Doppler ultrasound study 20 mg. @entity1 at 1, 2 to 3, 4 to 6 and 7 to 12 months postoperatively, respectively. In all cases the peak systolic velocity, end diastolic velocity and resistance index were evaluated at 5, 10 and 20 minutes after injection. RESULTS: Of the @entity0 36 received the intracavernous injection within the first 3 months (group 1) and 37 received it at 4 to 12 months (group 2). A significantly higher proportion of group 1 @entity0 had grade 3 erection compared with group 2. Peak systolic velocity less than 30 cm. per second in at least 1 cavernosal artery was recorded in 22.2% of group 1 @entity0 and 51.3% of group 2 (p >0.05). CONCLUSIONS: Intracavernous injections after nonnerve sparing radical prostatectomy produce valid erectile responses in a significantly higher proportion of @entity0 when started within month 3 after the operation. Injection given in postoperative month 1 gives the best response rate but with significant complications and poor @entity0 compliance. Arteriogenic and venogenic factors seem to be involved with failure.

title: Is there an optimal time for intracavernous XXXX rehabilitation following nonnerve sparing radical prostatectomy? Results from a hemodynamic prospective study.

answer: @entity1


abstract: PURPOSE: @entity4 is a common sequel of @entity3 , particularly those associated with posterior @entity2 when it can be neurogenic or arteriogenic due to damage to the cavernous nerves or branches of the pudendal arteries. We studied erectile function of @entity0 with posterior @entity2 due to @entity3 . MATERIALS AND METHODS: @entity0 referred for posterior urethral reconstruction and strictures due to @entity3 were evaluated before reconstruction. All @entity0 underwent nocturnal penile tumescence testing, and if those results were abnormal, penile duplex ultrasound with intracavernous injection was performed. @entity0 with normal vascular function on duplex ultrasound were diagnosed with @entity4 . Those @entity0 with abnormal arterial function on duplex ultrasound underwent arteriography to further define the extent and location of @entity1 . RESULTS: The study included 25 consecutive @entity0 with @entity5 and a mean age of 28.6 years. Of the @entity0 18 (72%) had @entity4 as demonstrated by nocturnal penile tumescence and all underwent penile duplex ultrasound. Ultrasound confirmed normal vascular response in 13 of the 18 @entity0 and they were diagnosed with probable @entity4 . The remaining 5 @entity0 (28%) with @entity4 had an abnormal arterial response, and significant arterial pathology was confirmed by arteriography. CONCLUSIONS: @entity4 is common in @entity0 with @entity3 associated with @entity2 . We believe that erectile function should be assessed and documented in such @entity0 before attempting urethroplasty. In the majority of these @entity0 @entity4 is caused by disruption of the cavernous nerves with sparing of arterial inflow.

title: The incidence and causes of XXXX after @entity3 associated with posterior urethral disruption.

answer: @entity4


abstract: PURPOSE: @entity4 is a common sequel of @entity3 , particularly those associated with posterior @entity2 when it can be neurogenic or arteriogenic due to damage to the cavernous nerves or branches of the pudendal arteries. We studied erectile function of @entity0 with posterior @entity2 due to @entity3 . MATERIALS AND METHODS: @entity0 referred for posterior urethral reconstruction and strictures due to @entity3 were evaluated before reconstruction. All @entity0 underwent nocturnal penile tumescence testing, and if those results were abnormal, penile duplex ultrasound with intracavernous injection was performed. @entity0 with normal vascular function on duplex ultrasound were diagnosed with @entity4 . Those @entity0 with abnormal arterial function on duplex ultrasound underwent arteriography to further define the extent and location of @entity1 . RESULTS: The study included 25 consecutive @entity0 with @entity5 and a mean age of 28.6 years. Of the @entity0 18 (72%) had @entity4 as demonstrated by nocturnal penile tumescence and all underwent penile duplex ultrasound. Ultrasound confirmed normal vascular response in 13 of the 18 @entity0 and they were diagnosed with probable @entity4 . The remaining 5 @entity0 (28%) with @entity4 had an abnormal arterial response, and significant arterial pathology was confirmed by arteriography. CONCLUSIONS: @entity4 is common in @entity0 with @entity3 associated with @entity2 . We believe that erectile function should be assessed and documented in such @entity0 before attempting urethroplasty. In the majority of these @entity0 @entity4 is caused by disruption of the cavernous nerves with sparing of arterial inflow.

title: The incidence and causes of @entity4 after XXXX associated with posterior urethral disruption.

answer: @entity3


abstract: Thirty-eight @entity0 with chronic calcifying @entity4 of the shoulder were randomized prospectively into two groups: 19 @entity0 had endoscopic decompression and 19 had open decompression. Thirty-three @entity0 (19 with open and 14 with endoscopic decompression) were available for followup. Clinical and ultrasonographic investigations were done at followup. The purpose of the current study was to evaluate prospectively the clinical and sonographic results after open decompression and after endoscopic decompression. Apportionment of age and gender was similar in both groups. The followup was 15.7 months for @entity0 after open decompression and 17.1 months for @entity0 after endoscopic decompression. The average Patte score was 84.5 points (84.4 for @entity0 who had endoscopic decompression and 84.6 for @entity0 who had open decompression). Corresponding results were found with a Constant and Murley score of 96.6 points (97.6 for @entity0 who had endoscopic decompression and 95.8 for @entity0 who had open decompression). In the endoscopic group physiotherapy was recommended for 5 weeks more than in the open surgery group. Similar results were seen for the incapacity to work in both groups with 4.6 weeks for the @entity0 who had endoscopic surgery and 5 weeks for the @entity0 who had open surgery. No nerve @entity1 , wound @entity3 , or other @entity2 were found. Comparison of both surgical methods showed good clinical and score results. Endoscopic and open surgery are equally effective in the treatment of chronic calcifying @entity4 .

title: Prospective randomized surgical treatments for calcifying XXXX .

answer: @entity4


abstract: Importance: @entity8 is an undifferentiated @entity4 with a high rate of regional and distant spread and a grave prognosis (median survival, 3 months) with no standardized treatment. Objective: To review the effect of an active treatment policy on the outcome of @entity8 . Design, Setting, and @entity0 : Retrospective comparative study of all @entity0 diagnosed as having @entity8 and undergoing treatment from January 1, 2008, through December 31, 2013, in a tertiary university-affiliated medical center. Data were collected by medical record review. Final follow-up was completed on November 30, 2014. Data were analyzed from December 1 to 3, 2014. Interventions: Treatment options included surgery and adjuvant concomitant radiotherapy and chemotherapy with @entity5 or @entity6 for @entity3 ; full-dose chemoradiotherapy (70 Gy to the gross @entity2 ) for @entity3 when surgery was not feasible; aggressive palliative radiotherapy (50 Gy to the gross @entity2 ) for @entity1 ; and palliative radiotherapy ( <=30 Gy) for @entity1 with a low performance status. Main Outcomes and Measures: Survival time and quality of life. Results: Of the 26 @entity0 (including 15 @entity0 ) who met the inclusion criteria, 11 underwent radiotherapy with curative intent. These @entity0 included 5 who underwent curative surgery (5 with chemotherapy) and 6 who received primary chemotherapy. Nine @entity0 received aggressive palliative radiotherapy, and 3 received palliative radiotherapy. The remaining 3 @entity0 were not treated. Curative radiotherapy was associated with a significantly longer overall median (95% CI) survival time (11 [8.1-13.9] months) than aggressive palliative radiotherapy (6 [3.1-8.9] months), palliative radiotherapy (3 [0.0-7.8] months), and no treatment (1 month) (P   <   .001). Chemotherapy in 10 @entity0 had a significant effect on survival (mean [95% CI], 11 [1.2-6.8] vs 4 [8.1-13.9] months for @entity0 who did not receive chemotherapy; P   =   .01). Among the @entity0 who underwent surgery and curative radiotherapy, 3 were alive after more than 3 years of follow-up. No association of survival with @entity0 sex (median [95% CI] survival for @entity0 and @entity0 , 9 [3.6-14.4] and 5 [0.3-9.7] months, respectively; P   =   .54) or a history of @entity7 (median [95% CI] survival for those with and without, 4 [1.0-6.9] and 9 [5.4-12.5] months, respectively; P   =   .15) was found. Conclusions and Relevance: @entity8 has a grave prognosis, but an aggressive approach, including surgery, chemotherapy, and radiotherapy, seems to improve survival. Higher doses of radiotherapy may have a survival benefit in candidates for palliative treatment and may be considered for @entity0 with @entity3 .

title: XXXX and Survival in Anaplastic Thyroid Carcinoma.

answer: @entity4


abstract: UNASSIGNED: OBJECTIVE To characterize serum a-1 @entity3 ( @entity3 ) and @entity4 ( @entity4 ) concentrations at diagnosis and during treatment in @entity1 with @entity2 . ANIMALS 16 @entity1 with various anatomic forms of @entity2 and 25 healthy @entity1 . PROCEDURES Blood samples were collected from healthy @entity1 once and from @entity1 with @entity2 at diagnosis and 2-week intervals until the 12th week of antineoplastic treatment. Serum harvested from blood samples was assessed for @entity3 and @entity4 concentrations. Differences in serum @entity3 and @entity4 values were investigated between healthy @entity1 and @entity1 with @entity2 (at diagnosis) and, for @entity1 with @entity2 , between diagnosis and various points during treatment. RESULTS Serum @entity3 and @entity4 concentrations were higher in @entity1 with @entity2 at diagnosis (median, 832.60 and 1.03  g/mL, respectively), compared with those in healthy @entity1 (median, 269.85 and 0.10  g/mL). Treatment resulted in a gradual decrease in serum @entity3 concentration after 4 weeks and in @entity4 concentration after 8 weeks of treatment, and these concentrations returned to values comparable with those of healthy @entity1 by 12 weeks of treatment, by which point all @entity1 had achieved complete remission of the disease. CONCLUSIONS AND CLINICAL RELEVANCE Serum @entity3 and @entity4 concentrations in @entity1 with @entity2 were higher at diagnosis than after antineoplastic treatment. Decreases to values established for healthy @entity1 corresponded with achievement of @entity0 . Serum @entity3 and @entity4 may be useful protein markers for monitoring of antineoplastic treatment in @entity1 with @entity2 .

title: Serum a-1 XXXX and @entity4 concentrations in cats receiving antineoplastic treatment for @entity2 .

answer: @entity3


abstract: UNASSIGNED: OBJECTIVE To characterize serum a-1 @entity3 ( @entity3 ) and @entity4 ( @entity4 ) concentrations at diagnosis and during treatment in @entity1 with @entity2 . ANIMALS 16 @entity1 with various anatomic forms of @entity2 and 25 healthy @entity1 . PROCEDURES Blood samples were collected from healthy @entity1 once and from @entity1 with @entity2 at diagnosis and 2-week intervals until the 12th week of antineoplastic treatment. Serum harvested from blood samples was assessed for @entity3 and @entity4 concentrations. Differences in serum @entity3 and @entity4 values were investigated between healthy @entity1 and @entity1 with @entity2 (at diagnosis) and, for @entity1 with @entity2 , between diagnosis and various points during treatment. RESULTS Serum @entity3 and @entity4 concentrations were higher in @entity1 with @entity2 at diagnosis (median, 832.60 and 1.03  g/mL, respectively), compared with those in healthy @entity1 (median, 269.85 and 0.10  g/mL). Treatment resulted in a gradual decrease in serum @entity3 concentration after 4 weeks and in @entity4 concentration after 8 weeks of treatment, and these concentrations returned to values comparable with those of healthy @entity1 by 12 weeks of treatment, by which point all @entity1 had achieved complete remission of the disease. CONCLUSIONS AND CLINICAL RELEVANCE Serum @entity3 and @entity4 concentrations in @entity1 with @entity2 were higher at diagnosis than after antineoplastic treatment. Decreases to values established for healthy @entity1 corresponded with achievement of @entity0 . Serum @entity3 and @entity4 may be useful protein markers for monitoring of antineoplastic treatment in @entity1 with @entity2 .

title: Serum a-1 @entity3 and XXXX concentrations in cats receiving antineoplastic treatment for @entity2 .

answer: @entity4


abstract: UNASSIGNED: OBJECTIVE To characterize serum a-1 @entity3 ( @entity3 ) and @entity4 ( @entity4 ) concentrations at diagnosis and during treatment in @entity1 with @entity2 . ANIMALS 16 @entity1 with various anatomic forms of @entity2 and 25 healthy @entity1 . PROCEDURES Blood samples were collected from healthy @entity1 once and from @entity1 with @entity2 at diagnosis and 2-week intervals until the 12th week of antineoplastic treatment. Serum harvested from blood samples was assessed for @entity3 and @entity4 concentrations. Differences in serum @entity3 and @entity4 values were investigated between healthy @entity1 and @entity1 with @entity2 (at diagnosis) and, for @entity1 with @entity2 , between diagnosis and various points during treatment. RESULTS Serum @entity3 and @entity4 concentrations were higher in @entity1 with @entity2 at diagnosis (median, 832.60 and 1.03  g/mL, respectively), compared with those in healthy @entity1 (median, 269.85 and 0.10  g/mL). Treatment resulted in a gradual decrease in serum @entity3 concentration after 4 weeks and in @entity4 concentration after 8 weeks of treatment, and these concentrations returned to values comparable with those of healthy @entity1 by 12 weeks of treatment, by which point all @entity1 had achieved complete remission of the disease. CONCLUSIONS AND CLINICAL RELEVANCE Serum @entity3 and @entity4 concentrations in @entity1 with @entity2 were higher at diagnosis than after antineoplastic treatment. Decreases to values established for healthy @entity1 corresponded with achievement of @entity0 . Serum @entity3 and @entity4 may be useful protein markers for monitoring of antineoplastic treatment in @entity1 with @entity2 .

title: Serum a-1 @entity3 and @entity4 concentrations in cats receiving antineoplastic treatment for XXXX .

answer: @entity2


abstract: Recent advances in radiation chemistry and radiation biology have led to the combined use of radiosensitizing agents with radiation in the treatment of @entity1 . Various chemicals, including cancerocidal drugs, are used, although radiation sensitizers are defined as drugs which can increase cellular radiosensitivity but have no direct cancerocidal effect. At least four classes of agents, @entity8 analogues, @entity4 cell sensitizers, PLDR inhibitors and @entity6 -depleting agents, can modify radiosensitivity and have potential for differential sensitization. @entity8 analogues are incorporated into DNA in replicating @entity1 cells, and can sensitize these cells to radiation up to a factor of 3. Results of clinical trials of intra-arterial infusion of BUdR have not proved satisfactory, especially with regard to long-term survival, possibly because of the existence of non-replicating cells in the @entity1 . The latter two are still in the experimental stage of study. The radioresistance of @entity4 cells in @entity1 has been regarded as one of the limiting factors in the local control of @entity1 by radiation. Attempts to improve the situation involve high-LET radiation and combined use of chemicals, such as @entity2 , prefluorochemicals and electron-affinic compounds, with low-LET radiation. Although some clinical trials in @entity3 and in cervical @entity1 have yielded positive results in @entity0 treated using hyperbaric @entity2 , attempts have been made to devise other methods, such as those using perfluorochemicals with normobaric @entity2 , because of the technical difficulty involved with the former method. A more promising and easier method is the combined use of electron-affinic chemicals, which like @entity2 can sensitize the @entity4 cells. @entity9 (alpha @entity10 derivative) was found to be an excellent sensitizer of this kind in cultured @entity0 cells and in some @entity1 . Several randomized clinical trials to determine its efficacy have been carried out on a word-wide scale, but most of them failed to demonstrate any beneficial effect, mainly because of the drug's @entity7 which limits its dose. After @entity9 , many researchers have made every effort to develop more @entity5 . The present state and future prospects of study were reviewed with special reference to studies currently being undertaken in Japan.

title: [Radiation sensitizers: with special reference to XXXX cell sensitizers].

answer: @entity4


abstract: PURPOSE: Laparoscopic pyeloplasty has become a viable option for the treatment of select @entity0 with primary @entity12 with success rates similar to those of open surgery. However, little has been written on the application of this technique for secondary @entity12 . We report the largest series of secondary @entity12 managed by laparoscopic pyeloplasty. MATERIALS AND METHODS: Between March 1994 and March 2001, 36 @entity0 underwent laparoscopic transperitoneal pyeloplasty for secondary @entity12 . The @entity0 had undergone an average of 1.3 ureteropelvic junction procedures (range 1 to 4) prior to presentation, including cutting balloon retrograde endopyelotomy in 28, antegrade endoscopic endopyelotomy in 7, retrograde endoscopic endopyelotomy in 4, @entity6 in 4 and open pyeloplasty in 3. A preoperative diagnosis of recurrent obstruction was confirmed by renal scan in 31 cases, retrograde pyelography in 2 and computerized tomography in 3. Of the 31 @entity0 who underwent spiral computerized tomography angiogram 87% had crossing vessels. Laparoscopic repair comprised dismembered pyeloplasty in 31 cases, Fengerplasty in 3 and flap repair in 2. Postoperative renal scan or excretory urography objective followup was available for all @entity0 at a mean of 10 months (range 3 to 40). Postoperative subjective @entity0 well-being was assessed using an analog @entity2 scale at a mean followup of 21.8 months (range 3 to 85). RESULTS: Average operative time was 6.2 hours (range 2.7 to 10). Average hospital stay was 2.9 days (range 1 to 7). One @entity11 occurred, that is bleeding necessitating conversion to an open procedure. @entity4 occurred in 8 cases, including @entity8 in 4, and @entity5 , @entity1 , @entity9 , @entity3 , @entity7 and stone formation 2 months postoperatively in 1 each. On excretory urography, @entity10 renal scan or the Whitaker test 32 of 36 @entity0 (89%) had a widely patent ureteropelvic junction. Two @entity0 (5.5%) had equivocal radiographic studies but were asymptomatic. In 2 @entity0 the ureteropelvic junction was obstructed by renal scan. One @entity0 had an indwelling stent for renal function deterioration and 1 was asymptomatic. Hence, 34 of the 36 @entity0 (94%) had a reasonable objective response. Overall a 50% or greater decrease in @entity2 was seen in 32 of 36 @entity0 (89%). In the 4 @entity0 with a less than 50% decrease in @entity2 objective renal scans showed an open ureteropelvic junction. As such, the overall success rate of a greater than 50% decrease in @entity2 , a patent ureteropelvic junction and stable or improved function of the affected renal unit was 83% (30 of 36 @entity0 ). CONCLUSIONS: For secondary @entity12 , laparoscopic pyeloplasty can be performed safely with a success rate comparable to that of standard open pyeloplasty. The @entity0 benefits of laparoscopic ureteropelvic junction repair of secondary @entity12 are similar to the benefits of laparoscopic repair of primary @entity12 .

title: Laparoscopic pyeloplasty for secondary XXXX .

answer: @entity12


abstract: Nine @entity0 with @entity7 ( @entity7 ) were treated by a portal systemic shunt. One had @entity4 of the superior mesenteric vein (SMV) and another had @entity8 (IVC). All other @entity0 had a marked stenosis of the retrohepatic IVC with caval pressure ranging from 12 to 24 mmHg (mean: 17 mmHg). Seven @entity0 had an interposition mesocaval shunt using an autologous jugular vein. The @entity0 with a thrombosed SMV had a portoatrial shunt. The @entity0 with an obstructed IVC had a cavoatrial shunt after an erroneous portacaval shunt had failed to relieve @entity5 . There were no operative deaths and no major @entity3 . One @entity0 died 19 months after operation of acute @entity6 complicating @entity9 rubra vera. All other @entity0 were alive and well 8 months to 6 years after operation. None of them had @entity2 . These results suggest several comments: Portal systemic shunts are a good treatment for @entity7 and have a low operative risk. The mesocaval shunt is an efficient procedure, even when there is stenosis of the IVC with high caval pressure; shunts to the right atrium should be performed only in the case of complete obstruction or inaccessibility of the IVC. The long-term prognosis is excellent, except in @entity0 with potential @entity1 . Therefore, portal systemic shunts should be indicated early in @entity0 with symptomatic @entity7 .

title: Results of portal systemic shunts in XXXX .

answer: @entity7


abstract: The optimum surgical procedure for treatment of @entity5 in the neonatal period remains controversial. To assess immediate and long-term results of using primarily the subclavian flap angioplasty procedure (SFA), we reviewed our initial 5-year experience. The average follow-up was 6 years. From 1977 to 1981, 25 @entity0 under 3 months of age (1 to 86 days, mean 21) required emergency surgery for repair of @entity5 . Three groups of @entity0 were identified. Group I consisted of 10 @entity0 with or without @entity7 . In group II, 10 @entity0 had @entity5 association with one or multiple @entity6 ( @entity6 ) without other @entity1 . In group III, 5 @entity0 had @entity5 associated with more complex congenital @entity3 . Twenty-three SFAs and two patch aortoplasties were performed. No @entity0 with isolated @entity6 was banded. All @entity0 except one in group III with an associated @entity4 survived initial hospitalizations. Four late @entity2 occurred, all in @entity0 with associated complex @entity3 . There were three recurrent coarctations requiring surgery or balloon angioplasty (12%)--one in each group, with a total rate of 0.77 recurrences per 100 @entity0 -months. SFA for @entity5 in the neonatal period is a safe and effective operation with a low initial mortality (4%, 0-19%, 70% confidence limits) well tolerated in this group of ill @entity0 . Long-term outcome is primarily related to the presence of associated complex @entity1 . @entity0 with @entity6 associated with @entity5 did not require pulmonary artery banding unless primary intracardiac repair was not feasible.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Repair of XXXX in the first three months of life: immediate and long-term results.

answer: @entity5


abstract: OBJECTIVE: To investigate pregnancy outcomes in @entity0 after abdominal radical trachelectomy (RT) for @entity1 . METHODS: The @entity0 ' background, fertility, and pregnancy outcomes were reviewed in a total of 61 pregnancies in 48 of 172 @entity0 who underwent abdominal RT at Keio University Hospital between September 2002 and December 2013. RESULTS: There were 5 @entity0 with stage @entity9 , 2 with stage @entity10 , and 41 with stage @entity6 . Histological types were as follows: @entity4 (n = 36), @entity2 (n = 10), and @entity5 (n = 2). The pregnancy rate of @entity0 attempting to conceive after abdominal RT was 44% (48/109). The mean    SD duration from abdominal RT to conception was 3.1    1.9 years. Of 61 pregnancies, 42 pregnancies were achieved by fertility treatment (in vitro fertilization-embryo transfer, 39; intrauterine insemination, 3). After excluding one pregnancy without detailed clinical information, there were 42 live births (5 in 22-27 weeks, 11 in 28-33weeks, 20 in 34-36 weeks, and 6 in 37-38 weeks), 13 miscarriages, and 5 ongoing pregnancies. While there were 10 first trimester miscarriages, 3 pregnancies ended in the second trimester owing to @entity7 . The mean gestational age at birth was 33 weeks of pregnancy. Thirty-seven neonates were appropriate-for-date, and one was small-for-date. Six pregnancies exhibited @entity3 from the residual cervix in the late pregnancy. Preterm birth less than 34 weeks of pregnancy was related to premature rupture of the membrane (P < 0.05). @entity7 was evident in 9 of 11 pregnancies with preterm premature rupture of the membrane followed by birth at less than 34 weeks of pregnancy. No parturients exhibited lochiometra and @entity8 . CONCLUSIONS: Abdominal RT provided favorable pregnancy outcomes, and fertility treatment could be advantageous to conception. Massive @entity3 from the residual cervix as well as ascending infection might be characteristic features during pregnancy after abdominal RT.

title: Pregnancy Outcomes After Abdominal Radical Trachelectomy for Early-Stage Cervical XXXX : A 13-Year Experience in a Single Tertiary-Care Center.

answer: @entity1


abstract: AIM: In Japan, @entity4 ( @entity4 ) is still rare, but the number of @entity0 with @entity4 has been steadily increasing. It is important for early diagnosis and early management of @entity4 to recognize epidemiological characteristics of this condition. METHODS: We investigated the epidemiological characteristics of 252 @entity0 with @entity4 who were admitted to our institutions between 1975 and 2001. @entity4 was more prevalent in @entity0 that in @entity0 . It was observed the most in the age group between 50s to 70s, especially in @entity0 . Many @entity0 had prolonged immobilization, recent major operation, @entity2 , or @entity1 , as risk factors for @entity5 . One hundred and thirty-eight @entity0 developed @entity4 in hospital; 60 @entity0 were in Department of Internal Medicine, 28 in General Surgery, 15 in Orthopedics, 15 in Obstetrics and Gynecology, and 20 in other services. RESULTS: Among 58 @entity0 with @entity1 , 43% had @entity1 in digestive organs, 21% in gynecological, and 17% in urological. Among 61 @entity0 who were examined for the presence of @entity3 , 13 @entity0 had inherited @entity3 (8 @entity7 , 4 @entity6 , and 1 @entity8 ) 11 had antiphospholipid antibodies which indicated @entity3 . Five out of the above 61 @entity0 (8%) had no obvious risk factors including @entity3 . CONCLUSION: The findings in our @entity0 were almost the same as those in Western @entity0 , except for some points. These results might be useful to establish a preventive approach for @entity4 in Japan.

title: Epidemiological characteristics of XXXX in Japan.

answer: @entity4


abstract: This study used a prospectively managed clinical database in order to identify 1470 @entity0 with @entity7 receiving protracted venous infusion (PVI) @entity6 (5FU). It aimed to determine the time course of @entity2 due to PVI 5FU and to analyse factors predicting @entity2 . The initial development of @entity8 occurred more rapidly than @entity3 or @entity9 ( @entity9 ). The percentage of @entity0 with National @entity1 Institute Common @entity2 Criteria (CTC) grade 2 or worse @entity9 peaked at 9% between weeks 8 and 17, whereas this peak occurred earlier for @entity8 and @entity3 . The development of CTC grade 1 @entity2 in the first 28 days after commencement of chemotherapy was classified as early grade 1 @entity2 . Multivariate Cox regression analysis showed that female sex, better performance status, elevated @entity5 , early grade 1 @entity9 and early grade 1 @entity3 were independent prognostic factors for the development of CTC grade 2 or worse @entity9 (P<0.01). Female sex, increased age, elevated @entity4 transaminase and urea and early grade 1 @entity9 were significant independent prognostic factors for the development of CTC grade 2 or worse @entity8 (P<0.01). Early CTC grade 1 @entity3 predicted CTC grade 2 or worse @entity3 (P<0.01). Older, female @entity0 with good performance status and impaired liver and renal function who develop early grade 1 @entity9 alone or in combination with @entity3 are at highest risk of subsequently developing grade 2 or worse @entity9 or @entity8 during treatment with PVI 5FU. Reduction of infused 5FU dose should be considered for these @entity0 . Such an approach could both reduce severe @entity2 owing to chemotherapy and minimise treatment delays, and should be evaluated prospectively.

title: Analysis of the time course and prognostic factors determining XXXX due to infused @entity6 .

answer: @entity2


abstract: This study used a prospectively managed clinical database in order to identify 1470 @entity0 with @entity7 receiving protracted venous infusion (PVI) @entity6 (5FU). It aimed to determine the time course of @entity2 due to PVI 5FU and to analyse factors predicting @entity2 . The initial development of @entity8 occurred more rapidly than @entity3 or @entity9 ( @entity9 ). The percentage of @entity0 with National @entity1 Institute Common @entity2 Criteria (CTC) grade 2 or worse @entity9 peaked at 9% between weeks 8 and 17, whereas this peak occurred earlier for @entity8 and @entity3 . The development of CTC grade 1 @entity2 in the first 28 days after commencement of chemotherapy was classified as early grade 1 @entity2 . Multivariate Cox regression analysis showed that female sex, better performance status, elevated @entity5 , early grade 1 @entity9 and early grade 1 @entity3 were independent prognostic factors for the development of CTC grade 2 or worse @entity9 (P<0.01). Female sex, increased age, elevated @entity4 transaminase and urea and early grade 1 @entity9 were significant independent prognostic factors for the development of CTC grade 2 or worse @entity8 (P<0.01). Early CTC grade 1 @entity3 predicted CTC grade 2 or worse @entity3 (P<0.01). Older, female @entity0 with good performance status and impaired liver and renal function who develop early grade 1 @entity9 alone or in combination with @entity3 are at highest risk of subsequently developing grade 2 or worse @entity9 or @entity8 during treatment with PVI 5FU. Reduction of infused 5FU dose should be considered for these @entity0 . Such an approach could both reduce severe @entity2 owing to chemotherapy and minimise treatment delays, and should be evaluated prospectively.

title: Analysis of the time course and prognostic factors determining @entity2 due to infused XXXX .

answer: @entity6


abstract: OBJECTIVE: To determine amniotic fluid @entity3 concentrations in @entity0 @entity6 ( @entity6 ) with respect to microbial invasion of the @entity4 (MIAC), @entity1 (IAI), microbial-associated IAI, histological @entity5 , and short-term neonatal morbidity. METHODS: One hundred forty-five @entity0 with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for @entity3 concentrations by ELISA. IAI was defined as amniotic fluid @entity2 > 745 pg/mL. Microbial-associated IAI was defined as the presence of both MIAC and IAI. RESULT: No differences in @entity3 concentrations were found between @entity0 with and without MIAC (p=0.27). @entity0 with IAI (p=0.0008) and microbial-associated IAI (p=0.01) had higher @entity3 concentrations than @entity0 without these complications. @entity0 with histological @entity5 had higher @entity3 concentrations only in crude analysis (p=0.02), but not after adjustment for gestational age at sampling (p=0.10). No associations between amniotic fluid @entity3 concentrations and the selected conditions of severe neonatal morbidity were found. CONCLUSIONS: The intraamniotic inflammatory response either to infectious or to non-infectious stimulus, but not microbial invasion of the @entity4 per se, seems to be a main factor associated with the elevation of the amniotic fluid @entity3 concentrations in @entity0 with @entity6 .

title: Amniotic fluid @entity3 in pregnancies complicated by XXXX .

answer: @entity6


abstract: OBJECTIVE: To determine amniotic fluid @entity3 concentrations in @entity0 @entity6 ( @entity6 ) with respect to microbial invasion of the @entity4 (MIAC), @entity1 (IAI), microbial-associated IAI, histological @entity5 , and short-term neonatal morbidity. METHODS: One hundred forty-five @entity0 with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for @entity3 concentrations by ELISA. IAI was defined as amniotic fluid @entity2 > 745 pg/mL. Microbial-associated IAI was defined as the presence of both MIAC and IAI. RESULT: No differences in @entity3 concentrations were found between @entity0 with and without MIAC (p=0.27). @entity0 with IAI (p=0.0008) and microbial-associated IAI (p=0.01) had higher @entity3 concentrations than @entity0 without these complications. @entity0 with histological @entity5 had higher @entity3 concentrations only in crude analysis (p=0.02), but not after adjustment for gestational age at sampling (p=0.10). No associations between amniotic fluid @entity3 concentrations and the selected conditions of severe neonatal morbidity were found. CONCLUSIONS: The intraamniotic inflammatory response either to infectious or to non-infectious stimulus, but not microbial invasion of the @entity4 per se, seems to be a main factor associated with the elevation of the amniotic fluid @entity3 concentrations in @entity0 with @entity6 .

title: Amniotic fluid XXXX in pregnancies complicated by @entity6 .

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: The fascia iliaca compartment block provides a faster and more consistent simultaneous blockade of the lateral cutaneous and femoral nerves than the "3 in 1" block. We studied the effectiveness of this technique for @entity4 after a femoral @entity3 in pre-hospital care. METHODS: @entity0 with an isolated femoral shaft @entity3 were included. A fascia iliaca compartment block was performed on all of them. Twenty milliliters of @entity6 1.5 % with @entity5 were injected under the fascia iliaca. The intensity of @entity2 was measured using a simplified verbal scale (SVS) from 0 (no @entity2 ) to 4 (extreme @entity2 ). The SVS was noted before the block was performed, 10 minutes later, and then on admission to the @entity1 care center. Sensory blockade was evaluated using cold perception in the lateral, medial, and internal part of the thigh 10 minutes after block performance and on arrival at the @entity1 care center. RESULTS: Twenty-seven @entity0 were enrolled in this study. The SVS was 3 (3-4) before the block, 1 (0-2) 10 minutes after the block, and 0 (0-1) when arriving at the @entity1 care center (P <.05). The SVS was lower when the internal part of the thigh was blocked. CONCLUSION: The fascia iliaca compartment block is a simple, inexpensive, and effective method of prehospital @entity4 for femoral shaft @entity3 . A sensory block of the internal part of the thigh is an early predictive sign of @entity2 relief.

title: Fascia iliaca compartment block for femoral XXXX in prehospital care.

answer: @entity3


abstract: UNASSIGNED: In recent years, the release of chemical pollutants to water bodies has increased due to anthropogenic activities. @entity5 is an essential metal that causes damage to aquatic biota at high concentrations. Phytoplankton are photosynthesizing microscopic organisms that constitute a fundamental community in aquatic environments because they are primary producers that sustain the aquatic food web. @entity4 @entity0 has not been characterized in all of the affected levels of biological organization. For this reason, the present study evaluated the toxic effects of @entity4 on the growth of a primary producer, the green microalga Ankistrodesmus falcatus, and on its biochemical, enzymatic, and structural levels. The IC50 (96h) was determined for @entity5 . Based on this result, five concentrations were determined for additional tests, in which cell density was evaluated daily. At the end of the assay, pigments and six biomarkers, including antioxidant enzymes (catalase [CAT], @entity2 peroxidase [GPx], @entity1 dismutase [SOD]), and macromolecules (proteins, @entity3 and lipids), were quantified; the integrated biomarker response (IBR) was determined also. The microalgae were observed by SEM and TEM. Population growth was affected starting at 7.5 gL(-1) (0.028 M), and at 120 gL(-1) (0.450 M), growth was inhibited completely; the determined IC50 was 17 gL(-1). Exposure to @entity4 reduced the concentration of pigments, decreased the content of all of the macromolecules, inhibited of SOD activity, and increased CAT and GPx activities. The IBR revealed that @entity5 increased the antioxidant response and diminished the macromolecules concentration. A. falcatus was affected by @entity4 at very low concentrations; negative effects were observed at the macromolecular, enzymatic, cytoplasmic, and morphological levels, as well as in population growth. @entity5 @entity0 could result in environmental impacts with consequences on the entire aquatic community. Current regulations should be revised to protect primary producers.

title: XXXX has biochemical, physiological, and structural effects on the green microalga Ankistrodesmus falcatus: An integrative study.

answer: @entity4


abstract: A simple, specific, and rapid confirmatory method for determining 12 @entity3 ( @entity4 ) antibacterials in @entity1 liver and kidney is presented. This method is based on the matrix solid-phase dispersion technique with hot water as extractant followed by liquid chromatography/mass spectrometry (LC/MS) with an electrospray ion source. The method was tailored for use with both single-quadrupole MS (I) and @entity0 (II) instruments. After acidification and filtration of the aqueous extract, a 250-microL aliquot was injected into instrument I while only 25 microL was analyzed by instrument II. With instrument I MS data acquisition was performed in the selected ion monitoring (SIM) mode, selecting at least three ions for each target compound. With instrument II the selected reaction monitoring (SRM) mode with three fragmentation reactions for each compound was chosen. With the exception of @entity5 (SQX), recovery of the analytes at the 50 ppb level in both liver and kidney was 72-96% with @entity2 ( @entity2 ) ranging between 3 and 11%. The very poor recovery of SQX was due to its rapid enzymatic oxidation when in contact with the two tissues. With instrument I, limits of quantification (LOQs, S/N = 10) were 5-14 ppb of @entity4 . Even lower LOQs (1-8 ppb) were estimated by using instrument II, even though the extract volume analyzed was ten times lower than that with instrument I. With both matrices and using instrument I, severe ion signal suppression was experienced for the early-eluted @entity4 when trying to fractionate analytes by using a short chromatographic run time. This effect was traced to polar endogenous co-extractives eluted in the first part of the chromatographic run that interfered with gas-phase ion formation for @entity4 . Adopting more selective chromatographic conditions minimized this effect.

title: Confirmatory analysis of @entity3 antibacterials in XXXX liver and kidney: extraction with hot water and liquid chromatography coupled to a single- or triple-quadrupole mass spectrometer.

answer: @entity1


abstract: A simple, specific, and rapid confirmatory method for determining 12 @entity3 ( @entity4 ) antibacterials in @entity1 liver and kidney is presented. This method is based on the matrix solid-phase dispersion technique with hot water as extractant followed by liquid chromatography/mass spectrometry (LC/MS) with an electrospray ion source. The method was tailored for use with both single-quadrupole MS (I) and @entity0 (II) instruments. After acidification and filtration of the aqueous extract, a 250-microL aliquot was injected into instrument I while only 25 microL was analyzed by instrument II. With instrument I MS data acquisition was performed in the selected ion monitoring (SIM) mode, selecting at least three ions for each target compound. With instrument II the selected reaction monitoring (SRM) mode with three fragmentation reactions for each compound was chosen. With the exception of @entity5 (SQX), recovery of the analytes at the 50 ppb level in both liver and kidney was 72-96% with @entity2 ( @entity2 ) ranging between 3 and 11%. The very poor recovery of SQX was due to its rapid enzymatic oxidation when in contact with the two tissues. With instrument I, limits of quantification (LOQs, S/N = 10) were 5-14 ppb of @entity4 . Even lower LOQs (1-8 ppb) were estimated by using instrument II, even though the extract volume analyzed was ten times lower than that with instrument I. With both matrices and using instrument I, severe ion signal suppression was experienced for the early-eluted @entity4 when trying to fractionate analytes by using a short chromatographic run time. This effect was traced to polar endogenous co-extractives eluted in the first part of the chromatographic run that interfered with gas-phase ion formation for @entity4 . Adopting more selective chromatographic conditions minimized this effect.

title: Confirmatory analysis of XXXX antibacterials in @entity1 liver and kidney: extraction with hot water and liquid chromatography coupled to a single- or triple-quadrupole mass spectrometer.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: B-cell @entity5 is a well-recognized entity and its characterization as low-grade (LG) and high-grade (HG) @entity3 has been widely accepted. In the present study we reviewed a series of 95 surgical specimens of primary @entity7 selected between 1979 and 1998. Immunohistochemical expression of @entity4 , @entity2 , and Ki67 and @entity6 (Hp) infection was evaluated, along with a correlation with clinical outcome. METHODS: A morphologic and immunohistochemical analysis, including @entity4 , @entity2 , and Ki67 expression, was carried out in all cases. A complete follow-up was obtained in 49 @entity0 and in these cases a survival analysis was performed. RESULTS: @entity2 protein was highly expressed in 25 of 25 assessed @entity1 and in 20 of 24 assessed @entity1 . @entity4 protein was expressed in 13 of 25 assessed @entity1 and in 21 of 24 assessed @entity1 . High proliferation rate as expressed by Ki67 was detected in 15 of 25 assessed @entity1 and in 23 of 24 assessed @entity1 . @entity8 was detected in 11 of 16 assessed @entity1 and 2 of 10 assessed @entity1 . Median survival rates were 72 months for @entity1 and 24 months for @entity1 . CONCLUSIONS: A significant inverse relationship between @entity8 and histological grade was found. High @entity4 expression and high-proliferation rate correlated with @entity1 . However, a correlation between @entity4 , @entity2 , and Ki67 expression with clinical outcome was not found.

title: Clinicopathologic and immunohistochemical study of surgically treated primary XXXX .

answer: @entity7


abstract: BACKGROUND: Lesion patterns may predict prognosis after acute @entity1 within the middle cerebral artery (MCA) territory; yet it remains unclear whether such imaging prognostic factors are related to @entity0 outcome after intravenous thrombolysis. AIMS: The aim of this study is to investigate the clinical outcome after intravenous thrombolysis in acute MCA @entity1 with respect to diffusion-weighted imaging (DWI) lesion patterns. METHODS: Consecutive acute @entity1 cases of the MCA territory treated over a 7-year period were retrospectively analyzed. All acute @entity4 @entity0 underwent a MRI scan before intravenous thrombolytic therapy was included. DWI lesions were divided into 6 patterns (territorial, other cortical, small superficial, internal border zone, small deep, and other @entity3 ). Lesion volumes were measured by dedicated imaging processing software. Favorable outcome was defined as modified Rankin scale (mRS) of 0-2 at 90 days. RESULTS: Among the 172 @entity0 included in our study, 75 (43.6%) were observed to have territorial @entity3 patterns or other deep @entity3 patterns. These @entity0 also had higher baseline NIHSS score (p < 0.001), a higher proportion of large cerebral @entity2 (p < 0.001) and larger @entity3 volume (p < 0.001). Favorable outcome (mRS 0-2) was achieved in 89 @entity0 (51.7%). After multivariable analysis, groups with specific lesion patterns, including territorial @entity3 and other deep @entity3 pattern, were independently associated with favorable outcome (OR 0.40; 95% CI 0.16-0.99; p = 0.047). CONCLUSIONS: Specific lesion patterns predict differential outcome after intravenous thrombolysis therapy in acute @entity4 @entity0 .

title: DWI Lesion Patterns Predict Outcome in Stroke XXXX with Thrombolysis.

answer: @entity0


abstract: BACKGROUND: Specialized @entity1 services for adolescents and young adults (AYAs) are being developed in a number of countries to address the particular needs of this population. However, the evidence base to inform service design and associated care delivery is inadequate. OBJECTIVE: The aim of this study was to undertake a mapping study to identify the main components of @entity1 care to be studied further to reflect the range of approaches to service delivery currently provided in England. METHODS: Semistructured interviews were conducted with young @entity0 , their family members, and staff in 11 AYA principal treatment centers. Using different levels of extraction, these data were drawn together to illuminate the main components of @entity1 care and the range of approaches to service delivery. RESULTS: Young @entity0 , family members, and staff consistently identified and valued similar areas of @entity1 care: caring and supportive staff, activities designed for AYAs, and an environment that feels like home. CONCLUSION: The mapping exercise successfully informed the selection of 4 sites for an in-depth case study. The main components of specialized AYA care have been described. IMPLICATIONS FOR PRACTICE: This description can assist clinical teams interested in developing or refining their approach to @entity1 care. It could also offer a way to agree priorities, based on the key components young @entity0 consider as being essential for their care, and facilitate services to benchmark against these key components, and it could also go some way to address international AYA goals to support global change to reduce the current disparities in care.

title: Mapping Adolescent Cancer Services: How Do Young XXXX , Their Families, and Staff Describe Specialized Cancer Care in England?

answer: @entity0


abstract: BACKGROUND: @entity5 @entity0 appear to be at high risk of developing @entity1 ( @entity1 ) and @entity2 during their stay in the @entity4 ( @entity4 ). However, little is known about the clinical course of @entity3 in the @entity4 setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of @entity1 on hospital and @entity4 stay, duration of mechanical ventilation and mortality in @entity5 @entity0 . We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the @entity4 setting. MATERIALS AND METHODS: MEDLINE and EMBASE databases were searched up to week 4 of June 2012. Two reviewers selected studies and extracted data. Pooled results are reported as relative risks and weighted mean differences and are presented with 95% confidence intervals (CI). RESULTS: Seven studies for a total of 1,783 @entity0 were included. A diagnosis of @entity1 was frequent in these @entity0 with a mean rate of 12.7% (95% CI: 8.7-17.5%). @entity1 @entity0 had longer @entity4 and hospital stays compared to those without @entity1 (7.28 days; 95% CI: 1.4-13.15; and 11.2 days; 95% CI: 3.82-18.63 days, respectively). The duration of mechanical ventilation was significantly increased in @entity1 @entity0 (weighted mean difference: 4.85 days; 95% CI: 2.07-7.63). @entity1 @entity0 had a marginally significant increase in the risk of hospital mortality (relative risk 1.31; 95% CI: 0.99-1.74; p=0.06), and a not statistically significant increase in the risk of @entity4 mortality ( @entity6 .64; 95% CI: 0.91-2.93; p=0.10). CONCLUSIONS: A diagnosis of @entity1 upon @entity4 admission appears to affect clinically important outcomes including duration of @entity4 and hospital stay and hospital mortality. Larger, prospective studies are warranted.

title: The impact of @entity1 in XXXX @entity0 : a meta-analysis of major clinical outcomes.

answer: @entity5


abstract: BACKGROUND: @entity5 @entity0 appear to be at high risk of developing @entity1 ( @entity1 ) and @entity2 during their stay in the @entity4 ( @entity4 ). However, little is known about the clinical course of @entity3 in the @entity4 setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of @entity1 on hospital and @entity4 stay, duration of mechanical ventilation and mortality in @entity5 @entity0 . We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the @entity4 setting. MATERIALS AND METHODS: MEDLINE and EMBASE databases were searched up to week 4 of June 2012. Two reviewers selected studies and extracted data. Pooled results are reported as relative risks and weighted mean differences and are presented with 95% confidence intervals (CI). RESULTS: Seven studies for a total of 1,783 @entity0 were included. A diagnosis of @entity1 was frequent in these @entity0 with a mean rate of 12.7% (95% CI: 8.7-17.5%). @entity1 @entity0 had longer @entity4 and hospital stays compared to those without @entity1 (7.28 days; 95% CI: 1.4-13.15; and 11.2 days; 95% CI: 3.82-18.63 days, respectively). The duration of mechanical ventilation was significantly increased in @entity1 @entity0 (weighted mean difference: 4.85 days; 95% CI: 2.07-7.63). @entity1 @entity0 had a marginally significant increase in the risk of hospital mortality (relative risk 1.31; 95% CI: 0.99-1.74; p=0.06), and a not statistically significant increase in the risk of @entity4 mortality ( @entity6 .64; 95% CI: 0.91-2.93; p=0.10). CONCLUSIONS: A diagnosis of @entity1 upon @entity4 admission appears to affect clinically important outcomes including duration of @entity4 and hospital stay and hospital mortality. Larger, prospective studies are warranted.

title: The impact of XXXX in @entity5 @entity0 : a meta-analysis of major clinical outcomes.

answer: @entity1


abstract: BACKGROUND: @entity5 @entity0 appear to be at high risk of developing @entity1 ( @entity1 ) and @entity2 during their stay in the @entity4 ( @entity4 ). However, little is known about the clinical course of @entity3 in the @entity4 setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of @entity1 on hospital and @entity4 stay, duration of mechanical ventilation and mortality in @entity5 @entity0 . We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the @entity4 setting. MATERIALS AND METHODS: MEDLINE and EMBASE databases were searched up to week 4 of June 2012. Two reviewers selected studies and extracted data. Pooled results are reported as relative risks and weighted mean differences and are presented with 95% confidence intervals (CI). RESULTS: Seven studies for a total of 1,783 @entity0 were included. A diagnosis of @entity1 was frequent in these @entity0 with a mean rate of 12.7% (95% CI: 8.7-17.5%). @entity1 @entity0 had longer @entity4 and hospital stays compared to those without @entity1 (7.28 days; 95% CI: 1.4-13.15; and 11.2 days; 95% CI: 3.82-18.63 days, respectively). The duration of mechanical ventilation was significantly increased in @entity1 @entity0 (weighted mean difference: 4.85 days; 95% CI: 2.07-7.63). @entity1 @entity0 had a marginally significant increase in the risk of hospital mortality (relative risk 1.31; 95% CI: 0.99-1.74; p=0.06), and a not statistically significant increase in the risk of @entity4 mortality ( @entity6 .64; 95% CI: 0.91-2.93; p=0.10). CONCLUSIONS: A diagnosis of @entity1 upon @entity4 admission appears to affect clinically important outcomes including duration of @entity4 and hospital stay and hospital mortality. Larger, prospective studies are warranted.

title: The impact of @entity1 in @entity5 XXXX : a meta-analysis of major clinical outcomes.

answer: @entity0


abstract: Regular intake of @entity1 is associated with elevated levels of high density lipoproteins (HDL). Opinions differ, however, on the HDL subfraction which is preferentially influenced by @entity1 . In the present study we measured the HDL subfraction lipid and protein concentrations and postheparin plasma lipase activities in chronic @entity1 users immediately after cessation of drinking and sequentially during one week of total abstention. The @entity4 mass concentration decreased significantly already during two abstinent days the decline continuing until the 8th day. At this time the mean @entity4 concentration had decreased by 38% from the initial value (P less than 0.05). The @entity4 @entity0 , phospholipid and protein concentrations decreased in approximately similar proportions, whereas the @entity4 @entity2 increased by 40%. The @entity5 mass concentration decreased by 13% but this change was not significant. Also in @entity5 the @entity0 , phospholipid and protein contents decreased to a similar extent but the @entity2 content rose. The postheparin plasma lipoprotein lipase activity decreased by 41% and the @entity3 by 37% during the abstention. It is concluded that in chronic alcoholics @entity4 accounts for the major part of the increase in HDL.

title: Rapid decrease in high density lipoprotein subfractions and postheparin plasma lipase activities after cessation of chronic XXXX intake.

answer: @entity1


abstract: Adherence of @entity0 with chronic conditions to their treatment is generally low. However, poor medication adherence or persistence reduces therapeutic effectiveness and increases morbidity and health care costs. This is also the case for anti- @entity1 treatments that, in order to be effective, must be taken correctly, regularly and long-term. The community pharmacist can play an important role in encouraging long-term adherence to antiosteoporotic treatments. To promote adherence, it is essential, from the beginning, to give to the @entity0 the information needed for a good understanding and a proper course of treatment. The repeated contact between pharmacist and @entity0 creates an opportunity to regularly assess adherence. In order to improve adherence, one needs to identify the causes of non-adherence and adapt the interventions accordingly. Persistence also requires follow-up of the @entity0 . Regular reassessment of @entity0 's adherence, taking into account changes that may affect his expectations, preferences and priorities, is essential to adjust interventions to his new needs. This article suggests ways and tools to improve therapeutic adherence, particularly in @entity1 @entity0 .

title: [How can the community pharmacist improve the adherence to anti- XXXX treatments].

answer: @entity1


abstract: BACKGROUND: Genital @entity3 ) is a common sexually transmitted @entity2 . In the first 10 years of sexual activity, point prevalence rates approach 25% and the lifetime risk of acquisition of this @entity2 may be as high as 80%. There are over 200 types of HPV, of which approximately 50 infect the genital area. OBJECTIVE: This article aims to discuss HPV detection and its role in @entity1 development. DISCUSSION: The HPV types that cause genital warts do not cause @entity1 . The subclinical types (especially types 16 and 18) are most frequently found in high grade epithelial abnormalities and therefore can potentially cause @entity1 . @entity3 is a 'necessary but not sufficient cause for @entity1 '. Most genital @entity4 is transient. @entity1 is actually a rare outcome of @entity4 . However, only 5% of @entity0 in developing countries have had a Pap smear in the past five years, and worldwide approximately 250 thousand @entity0 die of this disease every year. The role of HPV DNA testing has not yet been defined, but is no doubt a potential tool for the future. Meanwhile, international vaccine trials using HPV virus-like particles are taking place, and look promising.

title: XXXX : beware the @entity2 you can't see.

answer: @entity3


abstract: BACKGROUND: Genital @entity3 ) is a common sexually transmitted @entity2 . In the first 10 years of sexual activity, point prevalence rates approach 25% and the lifetime risk of acquisition of this @entity2 may be as high as 80%. There are over 200 types of HPV, of which approximately 50 infect the genital area. OBJECTIVE: This article aims to discuss HPV detection and its role in @entity1 development. DISCUSSION: The HPV types that cause genital warts do not cause @entity1 . The subclinical types (especially types 16 and 18) are most frequently found in high grade epithelial abnormalities and therefore can potentially cause @entity1 . @entity3 is a 'necessary but not sufficient cause for @entity1 '. Most genital @entity4 is transient. @entity1 is actually a rare outcome of @entity4 . However, only 5% of @entity0 in developing countries have had a Pap smear in the past five years, and worldwide approximately 250 thousand @entity0 die of this disease every year. The role of HPV DNA testing has not yet been defined, but is no doubt a potential tool for the future. Meanwhile, international vaccine trials using HPV virus-like particles are taking place, and look promising.

title: @entity3 : beware the XXXX you can't see.

answer: @entity2


abstract: @entity1 is a rare but dangerous condition. We present three cases of @entity1 . All three @entity0 were females. CT scan was performed. One @entity0 had a @entity3 in the left temporal lobe, but CT scan was normal in the last two cases. MRI later revealed that @entity1 was the diagnosis in all three cases. MRI is the examination of choice when @entity1 is suspected. The @entity0 were treated with heparin. One developed @entity4 due to @entity5 . One had discreet @entity2 , and the last @entity0 had no neurological sequelae after she was discharged from the hospital.

title: [ XXXX . Clinical presentation of three cases].

answer: @entity1