abstract: @entity2 has high rate of mortality among @entity1 . Because of its @entity3 and low rate of 5 year survival of @entity0 treated, it is important to realise a screening program for its early diagnosis. Today, immunologic research is directed to the study of tumoral markers that allow us to detect the presence of still clinically silent @entity2 . Some tumoral markers such as @entity4 and @entity5 are available for post-surgical monitoring of @entity0 treated for @entity2 . The Authors have carried out a study to evaluate the possibility of their use in the depistage of ovarian neoplastic pathology. A blood sample was taken for the evaluation of serum @entity4 and @entity5 in a series of 520 @entity0 older than 45 years, who did not complain signs or symptoms of pelvic pathology. A pathologic value for @entity4 was considered higher than 7.3 ng/ml and for @entity5 greater than 37 U/ml. For @entity4 2.5% (13 cases) presented pathologic values compared to 2.88% (15 cases) for @entity5 . One third of cases (0.5%) with high levels of @entity4 had repeated blood samples. 3 of them had confirmed high levels of @entity4 but echotomography performed in these @entity0 was negative for pathologic ovarian masses. 15 @entity0 had @entity5 high levels. 3 out of 15 cases repeated the blood sample that resulted normal. On 11 of these cases an echotomography was also performed that diagnosed a uterine myomatosis in 4 @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Tumoral markers ( XXXX -- @entity4 ) in the screening of @entity2 .

answer: @entity5


abstract: @entity2 has high rate of mortality among @entity1 . Because of its @entity3 and low rate of 5 year survival of @entity0 treated, it is important to realise a screening program for its early diagnosis. Today, immunologic research is directed to the study of tumoral markers that allow us to detect the presence of still clinically silent @entity2 . Some tumoral markers such as @entity4 and @entity5 are available for post-surgical monitoring of @entity0 treated for @entity2 . The Authors have carried out a study to evaluate the possibility of their use in the depistage of ovarian neoplastic pathology. A blood sample was taken for the evaluation of serum @entity4 and @entity5 in a series of 520 @entity0 older than 45 years, who did not complain signs or symptoms of pelvic pathology. A pathologic value for @entity4 was considered higher than 7.3 ng/ml and for @entity5 greater than 37 U/ml. For @entity4 2.5% (13 cases) presented pathologic values compared to 2.88% (15 cases) for @entity5 . One third of cases (0.5%) with high levels of @entity4 had repeated blood samples. 3 of them had confirmed high levels of @entity4 but echotomography performed in these @entity0 was negative for pathologic ovarian masses. 15 @entity0 had @entity5 high levels. 3 out of 15 cases repeated the blood sample that resulted normal. On 11 of these cases an echotomography was also performed that diagnosed a uterine myomatosis in 4 @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Tumoral markers ( @entity5 -- XXXX ) in the screening of @entity2 .

answer: @entity4


abstract: @entity2 has high rate of mortality among @entity1 . Because of its @entity3 and low rate of 5 year survival of @entity0 treated, it is important to realise a screening program for its early diagnosis. Today, immunologic research is directed to the study of tumoral markers that allow us to detect the presence of still clinically silent @entity2 . Some tumoral markers such as @entity4 and @entity5 are available for post-surgical monitoring of @entity0 treated for @entity2 . The Authors have carried out a study to evaluate the possibility of their use in the depistage of ovarian neoplastic pathology. A blood sample was taken for the evaluation of serum @entity4 and @entity5 in a series of 520 @entity0 older than 45 years, who did not complain signs or symptoms of pelvic pathology. A pathologic value for @entity4 was considered higher than 7.3 ng/ml and for @entity5 greater than 37 U/ml. For @entity4 2.5% (13 cases) presented pathologic values compared to 2.88% (15 cases) for @entity5 . One third of cases (0.5%) with high levels of @entity4 had repeated blood samples. 3 of them had confirmed high levels of @entity4 but echotomography performed in these @entity0 was negative for pathologic ovarian masses. 15 @entity0 had @entity5 high levels. 3 out of 15 cases repeated the blood sample that resulted normal. On 11 of these cases an echotomography was also performed that diagnosed a uterine myomatosis in 4 @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Tumoral markers ( @entity5 -- @entity4 ) in the screening of XXXX .

answer: @entity2


abstract: BACKGROUND: The outcome of @entity5 has remained constant over the past 30 years. Histological response to preoperative chemotherapy is the best predictor of outcome. Strategies to alter treatment based on histological response have not resulted in increased survival. PROCEDURE: @entity0 with @entity5 received preoperative chemotherapy with @entity8 , @entity6 , and @entity10 . @entity0 whose @entity1 had a good histological response (>= 90% @entity2 ) continued with the same treatment postoperatively. @entity0 with poor histological response (<90% @entity2 ) received three courses of @entity11 100 mg/m(2) on day -4, @entity7 2,000 mg/m(2) on days -3, and -2 followed by stem cell infusion. RESULTS: Fifty-two @entity0 were enrolled. Median age was 14 years, and 56% of @entity0 were male. The femur was the most common site. Forty @entity0 underwent limb salvage surgery and amputation was performed in six @entity0 . Forty-eight percent of @entity1 showed good histological response. Forty @entity0 were evaluable for outcome; 18 @entity0 with poor histologic response received high-dose chemotherapy. The 5-year event-free survival (EFS) and @entity9 ( @entity9 ) for @entity0 treated on the high-dose chemotherapy arm were 28% (95% confidence interval [CI], 10-49) and 48% (95% CI, 23-69), respectively. The 5-year EFS and @entity9 for @entity0 treated on the standard chemotherapy arm were 62% (95% CI, 36-80) and 74% (95% CI, 44-90), respectively. All @entity0 who received high-dose chemotherapy developed grade 3 or higher hematological @entity3 . There were no treatment-related @entity4 . CONCLUSIONS: Postoperative alkylator intensification with high-dose @entity7 and @entity11 in @entity0 with @entity5 with poor histological response failed to improve survival.

title: Risk-Based Therapy for XXXX .

answer: @entity5


abstract: Importance: There is extensive evidence suggesting that black @entity0 with @entity2 (PCa) have worse @entity1 -specific mortality compared with their non-Hispanic white counterparts. Objective: To evaluate racial disparities in the use, quality of care, and outcomes of radical prostatectomy (RP) in elderly @entity0 (>= 65 years) with nonmetastatic PCa. Design, Setting, and @entity0 : This retrospective analysis of outcomes stratified according to race (black vs non-Hispanic white) included 2020 elderly black @entity0 (7.6%) and 24   462 elderly non-Hispanic white @entity0 (92.4%) with localized PCa who underwent RP within the first year of PCa diagnosis in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database between 1992 and 2009. The study was performed in 2014. Main Outcomes and Measures: Process of care (ie, time to treatment, lymph node dissection), as well as outcome measures (ie, complications, emergency department visits, readmissions, PCa-specific and all-cause mortality, costs) were evaluated using Cox proportional hazards regression. Multivariable conditional logistic regression and quantile regression were used to study the association of racial disparities with process of care and outcome measures. Results: The proportion of black @entity0 with @entity2 who underwent RP within 90 days was 59.4% vs 69.5% of non-Hispanic white @entity0 (P   <   .001). In quantile regression of the top 50% of @entity0 , blacks had a 7-day treatment delay compared with non-Hispanic whites. (P   <   .001). Black @entity0 were less likely to undergo lymph node dissection (odds ratio [OR], 0.76 [95% CI, 0.66-0.80]; P   <   .001) but had higher odds of postoperative visits to the emergency department (within 30 days: OR, 1.48 [95% CI, 1.18-1.86]); after 30 days or more (OR, 1.45 [95% CI, 1.19-1.76]) and readmissions (within 30 days: OR, 1.28 [95% CI, 1.02-1.61]); >= 30 days (OR, 1.27 [95% CI, 1.07-1.51]) compared with non-Hispanic whites. The surgical treatment of black @entity0 was associated with a higher incremental annual cost (the top 50% of blacks spent  1185.50 (95% CI ,  804.85-1  1566.10; P   <   .001) more than the top 50% of non-Hispanic whites). There was no difference in PCa-specific mortality (P   =   .16) or all-cause mortality (P   =   .64) between black and non-Hispanic white @entity0 . Conclusions and Relevance: Blacks treated with RP for localized PCa are more likely to experience adverse events and incur higher costs compared with non-Hispanic white @entity0 ; however, this does not translate into a difference in PCa-specific or all-cause mortality.

title: Racial Differences in the Surgical Care of Medicare Beneficiaries With Localized XXXX .

answer: @entity2


abstract: BACKGROUND: We have previously shown that overall cost of hospitalization for Emergency General Surgery (EGS) diseases is over  28 billion annually and rising. The purpose of this study was to estimate the costs associated with specific @entity7 and identify factors associated with high cost hospitalizations. METHODS: The American Association for the Surgery of @entity4 definition was used to identify hospitalizations of adult EGS @entity1 in the 2010 National Inpatient Sample (NIS) data. Cost of each hospitalization was obtained utilizing cost-to-charge ratio in NIS. Regression analysis was used to estimate cost for each EGS disease adjusted for @entity1 and hospital characteristics. Hospitalizations with cost exceeding 75th percentile for each EGS disease were compared to lower cost hospitalizations to identify factors associated with high cost. RESULTS: Thirty-one @entity7 resulted in 2,602,074 hospitalizations nationwide in 2010 at an average adjusted cost of  10,110 (95% CI =  10,086 to  10,134) per hospitalization. Of these, only nine diseases constituted 80% of the total volume and 74% of the total cost. @entity6 , @entity3 , and small intestine @entity2 were the most expensive @entity7 with adjusted mean cost per hospitalization exceeding  20,000, while @entity0 , @entity5 , and soft tissue infection were the least expensive, with mean adjusted costs less than  7,000 per hospitalization. Most important factors associated with high cost hospitalizations was the number and type of procedures performed (76.2% of variance), but a region in Western United States (11.3%), Medicare and Medicaid payors (2.6%), and hospital ownership by public or not-for-profit entities (5.6%) were also associated with high cost hospitalizations. CONCLUSIONS: A small number of diseases constitute a vast majority of EGS hospitalizations and their cost. Attempts at reducing the cost of EGS hospitalization will require controlling the cost of procedures. LEVEL OF EVIDENCE: III.

title: Cost of Specific Emergency General Surgery Diseases and Factors Associated with High Cost XXXX .

answer: @entity1


abstract: To assess whether free radicals affect the characteristic sequence of events in an in vitro model of @entity0 and reperfusion, isolated @entity2 cardiac Purkinje fibers were exposed to anti-free radical agents, @entity1 dismutase 50 U/ml; @entity7 600 U/ml; @entity5 2 mM and 20 mM and combined @entity1 dismutase, @entity7 , and @entity5 20 mM. Fibers were superfused for 60 min with altered Tyrode's solution which mimicked some conditions of @entity0 ( @entity3 -free, containing @entity4 , equilibrated with 90% N2-10% @entity6 ), and then re-exposed to normal, oxygenated Tyrode's solution. Anti-free radical agents alone had no electrophysiological effects. Ischemic conditions resulted in moderate depolarization in most preparations (10 control; 43 treated) but in severe depolarization, to less than -60 mV, in some (3 control, 11 treated). Re-exposure to normal, oxygenated solution resulted in prompt initial hyperpolarization followed by marked depolarization, and finally by recovery to baseline maximum diastolic potential. Anti-free radical agents had not effect on maximum diastolic potential during exposure to @entity0 conditions or on initial hyperpolarization following re-exposure to oxygenated solution. Preparations that became severely depolarized during exposure to @entity0 conditions were not protected by anti-free radical interventions from developing marked depolarization following re-exposure to oxygenated solution. However, in fibers only moderately depolarized by the @entity0 conditions, all anti-free radical interventions except @entity5 , 2 mM significantly attenuated depolarization following re-exposure to oxygenated solution. Anti-free radical interventions significantly reduced the number of preparations that became markedly depolarized (to less than -65 mV) during re-exposure to oxygenated solution (except for @entity5 , 2 mM). Agents had no effect on the occurrence of abnormal automaticity; the occurrence of inexcitability was reduced, but not significantly, except when all agents were used in combination. The results suggest that free radical production may contribute to electrophysiological abnormalities when Purkinje fibers are re-exposed to oxygenated Tyrode's solution after they have been exposed to @entity0 conditions.

title: Electrophysiological effects of anti-free radical interventions in XXXX Purkinje fibers.

answer: @entity2


abstract: Conventional surgical treatment of @entity1 involves multiple or extensive resections or bypass procedures. These contribute to the morbidity and mortality of the disease. Minimal resection with appropriate "strictureplasty" is proposed as an alternative approach. Strictureplasty is analogous to pyloroplasty. The authors performed 15 strictureplasties in three @entity0 , all of whom had previously undergone small-bowel resection for @entity1 . They presented with symptoms of chronic @entity4 resistant to medical therapy. There were two minor @entity2 . Two @entity0 were asymptomatic 20 months postoperatively; the third required reoperation for recurrent @entity3 . The technique is safe. Its efficacy will be determined by long-term follow-up.

title: New options in the surgical management of XXXX .

answer: @entity1


abstract: OBJECTIVE: To investigate clinical effects of strategy by stages for preventing @entity5 of @entity0 with acute cervical @entity4 (ACSCI). METHODS: From September 2009 to May 2013,the clinical data of 91 @entity0 with ACSCI underwent surgery were retrospectively analyzed. Among the @entity0 , 42 @entity0 were divided into in-stages group, including 30 males and 12 females with an average age of 50 years old (ranged 28 to 76) which were treated with strategy by stages for preventing @entity5 ; others 49 @entity0 which were not treated with the strategy regarded as control group, including 38 males and 11 females with an average age of 47 years old (ranged 30 to 77). All of them had definite history of @entity2 , and were admitted to orthopaedics within 48 h after @entity2 . In in-stages group, respiratory muscle strength training, high-dose @entity6 using and other treatment were performed to prevent respiratory complilcations according to preoperative, intraoperative and postoperative stage. While in control group, there were no systematic and effective measures utilized. Chi-square test was used to evaluate the difference for @entity5 rate, the rate of tracheostomy or intubation and mortality caused by the @entity5 between two groups. RESULTS: Ten @entity0 developed with @entity5 in in-stages group (7 @entity0 with @entity1 , 1 with @entity3 and 2 with @entity5 ), among which 3 @entity0 underwent tracheostomy or intubation. In control group, 24 @entity0 developed with respiratory complilcations (15 with @entity1 ,3 with @entity3 and 6 with @entity5 ), among which 11 @entity0 underwent tracheostomy or intubation. There was significant difference between two groups (  2 = 6.12, 4.07; P = 0.013, 0.044). Five @entity0 died because of @entity5 , one case were in in-stages group and 4 in control group. There was significant difference between two groups (  2 = l.39, P = 0.238). CONCLUSION: The strategy by stages is an effective method for preventing @entity5 of ACSCI and can reduce the @entity5 rate and improve the prognosis of @entity5 .

title: [Strategy by stages for preventing XXXX of acute cervical @entity4 ].

answer: @entity5


abstract: OBJECTIVE: To investigate clinical effects of strategy by stages for preventing @entity5 of @entity0 with acute cervical @entity4 (ACSCI). METHODS: From September 2009 to May 2013,the clinical data of 91 @entity0 with ACSCI underwent surgery were retrospectively analyzed. Among the @entity0 , 42 @entity0 were divided into in-stages group, including 30 males and 12 females with an average age of 50 years old (ranged 28 to 76) which were treated with strategy by stages for preventing @entity5 ; others 49 @entity0 which were not treated with the strategy regarded as control group, including 38 males and 11 females with an average age of 47 years old (ranged 30 to 77). All of them had definite history of @entity2 , and were admitted to orthopaedics within 48 h after @entity2 . In in-stages group, respiratory muscle strength training, high-dose @entity6 using and other treatment were performed to prevent respiratory complilcations according to preoperative, intraoperative and postoperative stage. While in control group, there were no systematic and effective measures utilized. Chi-square test was used to evaluate the difference for @entity5 rate, the rate of tracheostomy or intubation and mortality caused by the @entity5 between two groups. RESULTS: Ten @entity0 developed with @entity5 in in-stages group (7 @entity0 with @entity1 , 1 with @entity3 and 2 with @entity5 ), among which 3 @entity0 underwent tracheostomy or intubation. In control group, 24 @entity0 developed with respiratory complilcations (15 with @entity1 ,3 with @entity3 and 6 with @entity5 ), among which 11 @entity0 underwent tracheostomy or intubation. There was significant difference between two groups (  2 = 6.12, 4.07; P = 0.013, 0.044). Five @entity0 died because of @entity5 , one case were in in-stages group and 4 in control group. There was significant difference between two groups (  2 = l.39, P = 0.238). CONCLUSION: The strategy by stages is an effective method for preventing @entity5 of ACSCI and can reduce the @entity5 rate and improve the prognosis of @entity5 .

title: [Strategy by stages for preventing @entity5 of acute cervical XXXX ].

answer: @entity4


abstract: OBJECTIVE: To determine the difference of post-operative mortality between @entity2 ( @entity2 ) and hip replacement for the treatment of @entity1 in elderly by using survival analysis. METHODS: The clinical data of 110 @entity0 above 60 years old who underwent surgical treatment ( @entity2 or hip replacement) for the @entity1 between April 2003 and May 2013 were retrospectively analyzed. Among the @entity0 , 83 cases were treated with @entity2 ( @entity2 group), there were 32 males and 51 females, aged from 61.44 to 98.75 years old with an average of (78.52    7.98) years old; and 27 cases were treated with hip replacement (arthroplasty group), there were 8 males and 19 females, aged from 71.82 to 96.54 years old with an average of (79.99    6.11) years old. A survival analysis was performed on the clinical data by using SPSS 110 software. The survival rate of 1-year,2-year, 5-year and the mean survival time for the total @entity0 , the mortality rate of 1-year, 2-year in each group, the survival rate of 1-year, 2-year and mean survival time and survival curve in each group were included. RESULTS: All wounds achieved primary healing and no deaths were found in stay hospital. All @entity0 were followed up from 1 to 125 months with an average of (46.93    29.53) months. Among all 110 cases, 31 were dead and 79 survived. The survival rate of 1-year, 2-year and 5-year was (90.7    2.8)%, (82.5    3.9)% and (57.6    6.5)%, respectively,while the ensemble mean survival time was (84.137    5.902) months. The mortality rate of 1-year, 2-year in @entity2 group was 7.2% and 12.0%, respectively; and in arthroplasty group, there was 14.8% and 25.9%, respectively. There was no significant difference in mortality rate of 1-year and 2-year between two groups. According to the survival analysis of the @entity2 group, the survival rate of 1-year, 2-year was (92.6    2.9)%, and (85.8    4.3)%, respectively, and the mean survival time was (87.508    6.063) months. In arthroplasty group, the survival rate of 1-year, 2-year was (85.2    6.8)% and (73.9    8.5)%,and the mean survival time was (67.294    11.180) months. There was significant difference in mean survival time between two groups (P < 0.05). CONCLUSION: @entity2 can achieve a better postoperative survival compare with hip replacement in treating @entity1 in elderly.

title: [Comparison of the prognosis of XXXX with different surgical methods in elderly: a retrospective survival analysis].

answer: @entity1


abstract: The objective of the present study was to investigate the effects of maternal administration of acute doses of @entity1 at preimplantation stages of pregnancy on the fetus and fetal membranes. Single doses of 0.02 ml and 0.03 ml/g body wt. of 25% v/v of absolute @entity1 in saline were administered to groups of @entity5 @entity0 on one of days 1-6 of gestation. Controls were either pair-fed and pair-watered or saline-treated. Fetuses and placentae were collected on day 15. Resorption and @entity6 were increased in most of the @entity1 treatment groups. The reduction in fetal body weight was significant in the 0.03 ml group. Compared to the saline controls, most experimental groups exhibited a rise in placental weight. The reduction in cord length was significant in comparison to untreated controls. Craniofacial and @entity4 appeared to correlate with retardation of fetal growth. Hence, following treatment of 0.03 ml/g body wt. of @entity1 solution on days 2 and 6, fetuses were collected on days 14, 16 and 18. Most fetuses were found to recover gradually from anomalies associated with @entity2 but the 'catch up' growth was not adequate enough to compensate for the reduction in body weight. These observations indicate that the pre-implantation stage of @entity0 embryo development is susceptible to the deleterious effects ( @entity6 and @entity3 ) of acute doses of @entity1 .

title: Effects of acute doses of ethanol administered at pre-implantation stages on fetal development in the XXXX .

answer: @entity0


abstract: Summary BACKGROUND: The transmission pathways of @entity4 are not fully understood. Solid evidence exists for an increased risk for individuals living in close contact with @entity2 @entity0 but the existence of @entity3 , environmental reservoirs and @entity1 -related transmission has also been established. PURPOSE: To assess the current state of knowledge on @entity4 transmission, we conducted a systematic review of the peer-reviewed literature pertaining to this topic. METHOD: Major electronic bibliographic databases were searched for relevant peer-reviewed articles published up to January 2014. No restrictions on study types, @entity0 and location were applied, and all outcomes demonstrated to contribute to the transmission of @entity4 were considered. Included studies were grouped by mode of transmission, namely (i) @entity0 -to- @entity0 via aerosols or direct contact; (ii) direct inoculation (e.g. injury); and (iii) transmission to @entity0 from environmental or zoonotic reservoirs, and by insects. The importance of the different transmission pathways and the strength of the evidence were assessed considering the number of publications describing similar findings, the consistency of the findings and the methodological quality of the studies. RESULTS: A total of 79 relevant articles were retained out of 3,805 hits resulting from the application of the search strategy. Solid evidence for transmission among contacts exists, and for @entity3 in the southern States of the USA. Based on the extant evidence, skin-to-skin contact, aerosols/droplets and shedding of bacteria into the environment and subsequent infection, e.g. through dust or small wounds, all remain possible options. CONCLUSION: No study has unequivocally demonstrated the mechanisms by which @entity4 bacteria travel from one case of @entity2 to another.

title: Current knowledge on XXXX transmission: a systematic literature review.

answer: @entity4


abstract: Treating @entity0 who have @entity2 in @entity1 hospitals is difficult for several reasons. The first reason is that there is a shortage of qualified psychiatrists. For each psychiatrist, there are approximately thirty hospitalized @entity0 . In addition to this limited number of psychiatrists, funding in @entity1 hospitals only provides for a limited number of other medical staff when compared with funding available for general hospitals. The second reason is that there is a problem with the national medical treatment fee system. Specifically, in the current system, @entity0 are not permitted to stay in hospitals long-term; outpatient treatment is preferred. The third reason is that @entity1 hospitals are not equipped to deal with @entity0 who have physical illnesses. The following two case studies highlight the problems and limitations associated with treating @entity0 who have @entity2 . Ways in which @entity1 hospitals can collaborate with other organizations, including low enforcement officials, are also considered. Although it is clear that an integrated and collaborative approach is necessary, implementation of such a system is still a long way from being realized, and greater effort is needed to provide @entity0 suffering from @entity2 with the best possible treatment.

title: [Limitations and Problems with Treatment of XXXX in a Psychiatric Hospital].

answer: @entity2


abstract: OBJECTIVE: To explore the effect of low-dose @entity3 (CP) on @entity4 ( @entity4 ) and inflammatory reaction of acute @entity0 reperfusion injury (IRI), providing new ideas for clinical treatment. MATERIALS AND METHODS: Sixty healthy adult male @entity1 were selected and divided randomly into sham operation group (n = 20), IRI group (n = 20 cases), and the experimental group (n = 20 cases). @entity1 in the experimental group were pretreated with low-dose CP and @entity5 . @entity6 ( @entity6 ) immunohistochemical staining was conducted after the 24h and the detection of @entity7 protein by Western blot method. Postoperative 3h and 7 day survival rate, the results of @entity6 immunohistochemistry staining and the gray values of @entity7 ( @entity7 ) of @entity1 were compared between the three groups. RESULTS: The survival rates of @entity1 in the IRI group and the experimental group after operation were decreased significantly (p < 0.05). However, the survival rates of @entity1 in the experimental group were higher than that in the IRI group. The differences were significant (p < 0.05). The expression of @entity6 was significantly reduced (p < 0.05). The difference was statistically significant. The expression of @entity6 was significantly reduced (p < 0.05). The gray values of @entity1 in the IRI group and the experimental group were significantly increased. The difference was statistically significant (p < 0.05). And the gray value in the IRI group increased more than that of the experimental group. The difference was statistically significant (p < 0.05). CONCLUSIONS: The pretreatment with low-dose CP for @entity1 with acute renal IRI can reduce effectively the @entity4 and @entity2 , which reduces @entity0 for @entity1 and have good effect on prolonging its life. It provides a good way for the guidance of clinical research.

title: Effect of low-dose @entity3 on @entity4 and inflammatory reaction of acute XXXX reperfusion injury.

answer: @entity0


abstract: OBJECTIVE: To explore the effect of low-dose @entity3 (CP) on @entity4 ( @entity4 ) and inflammatory reaction of acute @entity0 reperfusion injury (IRI), providing new ideas for clinical treatment. MATERIALS AND METHODS: Sixty healthy adult male @entity1 were selected and divided randomly into sham operation group (n = 20), IRI group (n = 20 cases), and the experimental group (n = 20 cases). @entity1 in the experimental group were pretreated with low-dose CP and @entity5 . @entity6 ( @entity6 ) immunohistochemical staining was conducted after the 24h and the detection of @entity7 protein by Western blot method. Postoperative 3h and 7 day survival rate, the results of @entity6 immunohistochemistry staining and the gray values of @entity7 ( @entity7 ) of @entity1 were compared between the three groups. RESULTS: The survival rates of @entity1 in the IRI group and the experimental group after operation were decreased significantly (p < 0.05). However, the survival rates of @entity1 in the experimental group were higher than that in the IRI group. The differences were significant (p < 0.05). The expression of @entity6 was significantly reduced (p < 0.05). The difference was statistically significant. The expression of @entity6 was significantly reduced (p < 0.05). The gray values of @entity1 in the IRI group and the experimental group were significantly increased. The difference was statistically significant (p < 0.05). And the gray value in the IRI group increased more than that of the experimental group. The difference was statistically significant (p < 0.05). CONCLUSIONS: The pretreatment with low-dose CP for @entity1 with acute renal IRI can reduce effectively the @entity4 and @entity2 , which reduces @entity0 for @entity1 and have good effect on prolonging its life. It provides a good way for the guidance of clinical research.

title: Effect of low-dose @entity3 on XXXX and inflammatory reaction of acute @entity0 reperfusion injury.

answer: @entity4


abstract: OBJECTIVE: To explore the effect of low-dose @entity3 (CP) on @entity4 ( @entity4 ) and inflammatory reaction of acute @entity0 reperfusion injury (IRI), providing new ideas for clinical treatment. MATERIALS AND METHODS: Sixty healthy adult male @entity1 were selected and divided randomly into sham operation group (n = 20), IRI group (n = 20 cases), and the experimental group (n = 20 cases). @entity1 in the experimental group were pretreated with low-dose CP and @entity5 . @entity6 ( @entity6 ) immunohistochemical staining was conducted after the 24h and the detection of @entity7 protein by Western blot method. Postoperative 3h and 7 day survival rate, the results of @entity6 immunohistochemistry staining and the gray values of @entity7 ( @entity7 ) of @entity1 were compared between the three groups. RESULTS: The survival rates of @entity1 in the IRI group and the experimental group after operation were decreased significantly (p < 0.05). However, the survival rates of @entity1 in the experimental group were higher than that in the IRI group. The differences were significant (p < 0.05). The expression of @entity6 was significantly reduced (p < 0.05). The difference was statistically significant. The expression of @entity6 was significantly reduced (p < 0.05). The gray values of @entity1 in the IRI group and the experimental group were significantly increased. The difference was statistically significant (p < 0.05). And the gray value in the IRI group increased more than that of the experimental group. The difference was statistically significant (p < 0.05). CONCLUSIONS: The pretreatment with low-dose CP for @entity1 with acute renal IRI can reduce effectively the @entity4 and @entity2 , which reduces @entity0 for @entity1 and have good effect on prolonging its life. It provides a good way for the guidance of clinical research.

title: Effect of low-dose XXXX on @entity4 and inflammatory reaction of acute @entity0 reperfusion injury.

answer: @entity3


abstract: @entity5 Marburg strain displays DNA methyltransferase activity. This enzyme, M.BsuM, methylates @entity6 in the sequence 5'-YTCGAR-3' (Y = @entity7 ; R = @entity9 ). M.BsuM was purified from the exponentially growing cells of @entity8 M. This enzyme (45 +/- 1 kDa) is monomeric and recognizes only double-stranded DNA. It is inhibited partially by @entity1 , @entity4 ions and @entity10 and almost totally by @entity3 , @entity2 and agarose. This enzyme methylates specifically the three methylatable sites of the plasmid pBM3. Relaxation of specificity ('star' activity) was observed in the presence of organic solvents. A very low amount of M.BsuM was obtained in the standard Marburg strain. To obtain sufficient enzyme attempts are being made to clone the M.BsuM gene in @entity0 by using a constructed plasmid (pBM14) vector. Only one transformant containing a 3-kb insert and showing a low level of expression, was obtained.

title: DNA methyltransferase of XXXX Marburg: purification, properties and further evidence of specificity.

answer: @entity5


abstract: The @entity2 ( @entity2 ) and the @entity3 ( @entity3 ) both have multiple hamartomata as prominent features. @entity6 , @entity7 , exostoses, @entity1 , @entity4 , and sporadic occurrence are seen in @entity2 , whereas @entity0 with @entity3 have @entity5 and related craniofacial findings. @entity3 has been observed in families as an autosomal dominant trait. Although the two syndromes can be distinguished in most @entity0 , there are features in common to both that may pose a diagnostic dilemma in an isolated case. We report the case of a 3-year-old @entity0 with @entity5 , @entity7 , and superficial and intra-abdominal hamartomata who illustrates the problem of differentiating between @entity2 and @entity3 . We compare this @entity0 and another recently reported @entity0 with other published cases of @entity2 and @entity3 . @entity0 with @entity2 , in general, show more extensive systemic involvement, including skeletal and cutaneous manifestations. @entity5 , seen in all reported @entity0 with @entity3 , is also found in 14% of @entity0 with @entity2 . Overlap among syndromes which include hamartomata as prominent features suggests that they might be etiologically or pathogenetically related. The present case also illustrates the usefulness of imaging techniques in the diagnosis of mixed mesodermal hamartomata.

title: @entity2 versus XXXX : a problem in differential diagnosis.

answer: @entity3


abstract: The @entity2 ( @entity2 ) and the @entity3 ( @entity3 ) both have multiple hamartomata as prominent features. @entity6 , @entity7 , exostoses, @entity1 , @entity4 , and sporadic occurrence are seen in @entity2 , whereas @entity0 with @entity3 have @entity5 and related craniofacial findings. @entity3 has been observed in families as an autosomal dominant trait. Although the two syndromes can be distinguished in most @entity0 , there are features in common to both that may pose a diagnostic dilemma in an isolated case. We report the case of a 3-year-old @entity0 with @entity5 , @entity7 , and superficial and intra-abdominal hamartomata who illustrates the problem of differentiating between @entity2 and @entity3 . We compare this @entity0 and another recently reported @entity0 with other published cases of @entity2 and @entity3 . @entity0 with @entity2 , in general, show more extensive systemic involvement, including skeletal and cutaneous manifestations. @entity5 , seen in all reported @entity0 with @entity3 , is also found in 14% of @entity0 with @entity2 . Overlap among syndromes which include hamartomata as prominent features suggests that they might be etiologically or pathogenetically related. The present case also illustrates the usefulness of imaging techniques in the diagnosis of mixed mesodermal hamartomata.

title: XXXX versus @entity3 : a problem in differential diagnosis.

answer: @entity2


abstract: Serum and urinary concentrations of @entity3 ( @entity2 ) were measured by high-performance liquid chromatography (HPLC) with an electrochemical detector (ECD) in 10 normal subjects and 43 @entity1 @entity0 after intravenous and oral administration of the drug. The pharmacokinetic parameters of @entity2 were estimated in 5 normal subjects and 15 @entity1 @entity0 according to a two-compartment model after intravenous injection of a 10 mg dose. The mean half-life of the distribution phase ( @entity4 ) was 2.7 +/- 1.0 h (mean +/- SD) and 3.1 +/- 1.4 h and that of the slower-phase ( @entity4 ) was 20.7 +/- 9.6 h and 18.5 +/- 12.9 h in normal subjects and @entity1 @entity0 , respectively. There were no significant differences between pharmacokinetic parameters of normal subjects and those of @entity1 @entity0 . No correlations between free T4 index (FT4I) and pharmacokinetic parameters were observed. Maximum serum @entity2 concentrations (Cmax) (213 +/- 84 and 299 +/- 92 ng/ml) were attained 1.8 +/- 1.4 h and 2.3 +/- 0.8 h after a single dose of 10 mg in 5 normal subjects and in 15 @entity1 @entity0 , respectively. In @entity1 @entity0 the time taken to reach the peak concentration (Tmax) after a single dose of 10 mg was similar to that after a single 15 mg and 30 mg dose. The pharmacokinetic parameters, except Cmax and the area under the curve (AUC), were not affected by the administered dose and those, except Cmax, were not affected by the thyroid function. All urine was collected at intervals of 3 h for the first 12 h and then at 24 h and 48 h after intravenous and oral administration of @entity2 . In all subjects, @entity2 rapidly appeared in the urine and the rate of excretion was highest in the first 3 h. The cumulative urinary excretion of @entity2 was 5.5-8.5% of administered doses in normal subjects and @entity1 @entity0 . These findings in the present study are compatible with the assumption that the extent of absorption of @entity2 is high, if not complete, and @entity1 does not affect the kinetics of @entity2 , and that interindividual variation is observed in the time taken to reach the peak concentration after oral administration.

title: Pharmacokinetics of XXXX in normal subjects and @entity1 @entity0 .

answer: @entity3


abstract: Serum and urinary concentrations of @entity3 ( @entity2 ) were measured by high-performance liquid chromatography (HPLC) with an electrochemical detector (ECD) in 10 normal subjects and 43 @entity1 @entity0 after intravenous and oral administration of the drug. The pharmacokinetic parameters of @entity2 were estimated in 5 normal subjects and 15 @entity1 @entity0 according to a two-compartment model after intravenous injection of a 10 mg dose. The mean half-life of the distribution phase ( @entity4 ) was 2.7 +/- 1.0 h (mean +/- SD) and 3.1 +/- 1.4 h and that of the slower-phase ( @entity4 ) was 20.7 +/- 9.6 h and 18.5 +/- 12.9 h in normal subjects and @entity1 @entity0 , respectively. There were no significant differences between pharmacokinetic parameters of normal subjects and those of @entity1 @entity0 . No correlations between free T4 index (FT4I) and pharmacokinetic parameters were observed. Maximum serum @entity2 concentrations (Cmax) (213 +/- 84 and 299 +/- 92 ng/ml) were attained 1.8 +/- 1.4 h and 2.3 +/- 0.8 h after a single dose of 10 mg in 5 normal subjects and in 15 @entity1 @entity0 , respectively. In @entity1 @entity0 the time taken to reach the peak concentration (Tmax) after a single dose of 10 mg was similar to that after a single 15 mg and 30 mg dose. The pharmacokinetic parameters, except Cmax and the area under the curve (AUC), were not affected by the administered dose and those, except Cmax, were not affected by the thyroid function. All urine was collected at intervals of 3 h for the first 12 h and then at 24 h and 48 h after intravenous and oral administration of @entity2 . In all subjects, @entity2 rapidly appeared in the urine and the rate of excretion was highest in the first 3 h. The cumulative urinary excretion of @entity2 was 5.5-8.5% of administered doses in normal subjects and @entity1 @entity0 . These findings in the present study are compatible with the assumption that the extent of absorption of @entity2 is high, if not complete, and @entity1 does not affect the kinetics of @entity2 , and that interindividual variation is observed in the time taken to reach the peak concentration after oral administration.

title: Pharmacokinetics of @entity3 in normal subjects and XXXX @entity0 .

answer: @entity1


abstract: Serum and urinary concentrations of @entity3 ( @entity2 ) were measured by high-performance liquid chromatography (HPLC) with an electrochemical detector (ECD) in 10 normal subjects and 43 @entity1 @entity0 after intravenous and oral administration of the drug. The pharmacokinetic parameters of @entity2 were estimated in 5 normal subjects and 15 @entity1 @entity0 according to a two-compartment model after intravenous injection of a 10 mg dose. The mean half-life of the distribution phase ( @entity4 ) was 2.7 +/- 1.0 h (mean +/- SD) and 3.1 +/- 1.4 h and that of the slower-phase ( @entity4 ) was 20.7 +/- 9.6 h and 18.5 +/- 12.9 h in normal subjects and @entity1 @entity0 , respectively. There were no significant differences between pharmacokinetic parameters of normal subjects and those of @entity1 @entity0 . No correlations between free T4 index (FT4I) and pharmacokinetic parameters were observed. Maximum serum @entity2 concentrations (Cmax) (213 +/- 84 and 299 +/- 92 ng/ml) were attained 1.8 +/- 1.4 h and 2.3 +/- 0.8 h after a single dose of 10 mg in 5 normal subjects and in 15 @entity1 @entity0 , respectively. In @entity1 @entity0 the time taken to reach the peak concentration (Tmax) after a single dose of 10 mg was similar to that after a single 15 mg and 30 mg dose. The pharmacokinetic parameters, except Cmax and the area under the curve (AUC), were not affected by the administered dose and those, except Cmax, were not affected by the thyroid function. All urine was collected at intervals of 3 h for the first 12 h and then at 24 h and 48 h after intravenous and oral administration of @entity2 . In all subjects, @entity2 rapidly appeared in the urine and the rate of excretion was highest in the first 3 h. The cumulative urinary excretion of @entity2 was 5.5-8.5% of administered doses in normal subjects and @entity1 @entity0 . These findings in the present study are compatible with the assumption that the extent of absorption of @entity2 is high, if not complete, and @entity1 does not affect the kinetics of @entity2 , and that interindividual variation is observed in the time taken to reach the peak concentration after oral administration.

title: Pharmacokinetics of @entity3 in normal subjects and @entity1 XXXX .

answer: @entity0


abstract: A retrospective study is presented of 200 cases of @entity1 admitted to Auckland Hospital over the 6-year period 1979-84. The epidemiology of the total group, the mode or type of presentation, pathology and investigative practice have been examined. Seventy-six @entity0 required surgical intervention either electively or as an emergency and these cases have been considered in detail. The surgical group included 44 @entity0 and 32 @entity0 ; 21 @entity0 presented for elective resection, and 55 @entity0 underwent surgery during their emergency admission. In the emergency group, 20 laparotomies were performed for pericolic/pelvic abscesses, five for small/large bowel obstruction, 30 for @entity3 and only one laparotomy was performed for @entity4 . The mortality for the entire group was 4% with all @entity2 occurring in the @entity6 group. Three @entity2 followed emergency surgery and a further five @entity0 died without coming to surgery, the diagnosis of @entity6 being made only at post-mortem. Overall, 44% of cases of @entity6 underwent emergency surgery and a further 6% required surgery over the next 1-5 years. Resectional surgery was practised widely in the emergency group (the most common being Hartmann's operation). Less radical surgery is also preferred for localized sepsis in selected cases. The mortality was confined to @entity0 who did not undergo resection of the septic focus. The elective group (24 @entity0 ) usually presented as a result of stricture, or chronic symptoms, and these @entity0 generally did well with elective resection. The group of @entity0 presenting with @entity5 behaved in a very benign manner. There was no mortality and only one @entity0 required emergency surgery for @entity4 .

title: XXXX in Auckland.

answer: @entity1


abstract: UNASSIGNED: Transcatheter @entity3 (TAVI) has been established as a valuable alternative to surgical aortic valve replacement in @entity0 deemed to have high or prohibitive perioperative risk. However, there are several technical constraints and procedural risks inherent to TAVI. These risks include @entity2 , @entity7 , @entity5 , @entity4 , and dislodgement or migration of the valve prosthesis to the aorta or the left ventricle (LV). Other complications may be @entity1 and subsequent @entity6 . Most complications cannot be detected at an early stage without echocardiographic guidance. Although not addressed by current guidelines, some European centres have advocated a 'minimalist' approach with exclusively fluoroscopic and angiographic guidance. Transoesophageal echocardiography (TEE), including real-time three-dimensional (RT-3D) imaging, has been established as a standard approach for peri-interventional guidance of TAVI. However, TEE monitoring almost always necessitates general anaesthesia and endotracheal intubation. A potential alternative to TEE is intracardiac echocardiography (ICE) that may provide a solution to a common dilemma: the most important advantage of ICE being the compatibility with monitored anaesthesia care without endotracheal intubation. Other advantages of ICE include uninterrupted monitoring, no fluoroscopic interference, and precise Doppler-based assessment of pulmonary artery pressures. Limitations of ICE include the need for additional venous access, the learning curve associated with a new device, and potentially increased cost.

title: Intracardiac echocardiography for guidance of transcatheter XXXX under monitored sedation: a solution to a dilemma?

answer: @entity3


abstract: BACKGROUND: To date, the optimal surgical strategy for @entity3 has not been determined. The purpose of this study was to clarify the significance of lymphadenectomy with splenectomy in @entity3 surgery. METHODS: This retrospective cohort study was conducted at the Kumamoto Regional Medical Center. The primary endpoint was overall survival after surgery. We retrospectively analyzed the clinicopathologic features, surgical treatments, and long-term prognosis of @entity3 @entity0 treated with total gastrectomy. RESULTS: A total of 80 @entity0 with @entity3 in the remnant stomach after distal gastrectomy and who underwent total gastrectomy were enrolled in the study. Splenectomy was performed in 38 @entity0 . Lymph node @entity1 in the splenic hilum was not observed in the @entity0 with @entity5 /pT2 @entity2 , whereas nodal @entity1 at the splenic hilum was detected in 30.4% of the @entity0 with @entity4 /pT4 @entity2 . The survival rate of the @entity0 with @entity4 /pT4 @entity2 who underwent splenectomy was significantly higher than that of the @entity0 who did not undergo splenectomy, although there was no difference in the @entity0 with @entity5 /pT2 @entity2 . Among the @entity0 classified as R0, the survival rate of the @entity0 with @entity4 /pT4 @entity2 who underwent splenectomy was significantly higher than that of the @entity0 who did not undergo splenectomy. CONCLUSION: Lymphadenectomy with splenectomy in radical surgery is beneficial for @entity0 with advanced ( @entity4 /pT4) @entity3 .

title: Significance of lymphadenectomy with splenectomy in radical surgery for advanced ( @entity4 /pT4) XXXX .

answer: @entity3


abstract: BACKGROUND: To date, the optimal surgical strategy for @entity3 has not been determined. The purpose of this study was to clarify the significance of lymphadenectomy with splenectomy in @entity3 surgery. METHODS: This retrospective cohort study was conducted at the Kumamoto Regional Medical Center. The primary endpoint was overall survival after surgery. We retrospectively analyzed the clinicopathologic features, surgical treatments, and long-term prognosis of @entity3 @entity0 treated with total gastrectomy. RESULTS: A total of 80 @entity0 with @entity3 in the remnant stomach after distal gastrectomy and who underwent total gastrectomy were enrolled in the study. Splenectomy was performed in 38 @entity0 . Lymph node @entity1 in the splenic hilum was not observed in the @entity0 with @entity5 /pT2 @entity2 , whereas nodal @entity1 at the splenic hilum was detected in 30.4% of the @entity0 with @entity4 /pT4 @entity2 . The survival rate of the @entity0 with @entity4 /pT4 @entity2 who underwent splenectomy was significantly higher than that of the @entity0 who did not undergo splenectomy, although there was no difference in the @entity0 with @entity5 /pT2 @entity2 . Among the @entity0 classified as R0, the survival rate of the @entity0 with @entity4 /pT4 @entity2 who underwent splenectomy was significantly higher than that of the @entity0 who did not undergo splenectomy. CONCLUSION: Lymphadenectomy with splenectomy in radical surgery is beneficial for @entity0 with advanced ( @entity4 /pT4) @entity3 .

title: Significance of lymphadenectomy with splenectomy in radical surgery for advanced ( XXXX /pT4) @entity3 .

answer: @entity4


abstract: BACKGROUND: The Lyon brace is commonly prescribed in many European countries to @entity0 with thoracic curves and is based on the three-point pressure system. The purpose of this study was to evaluate the efficacy of Lyon bracing for the conservative treatment of adolescent females with @entity1 in a case series selected on the basis of the @entity2 ( @entity2 ) Committee on Bracing and Nonoperative Management Standardization Criteria and followed the guidelines on management of @entity3 with corrective braces, proposed by the International Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT). METHODS: Prospective study based on an ongoing database. From 1297 @entity0 treated for @entity3 between 1995 and 2014 fulfill the inclusion criteria 102 @entity0 treated with Lyon brace. Of these, 69 @entity0 had a definite outcome, 17 have abandoned treatment e 16 are still in treatment. The 104 @entity0 were adolescent females with curvatures in the thoracic spine and a pre-treatment Risser score ranging from 0 to 2. All @entity0 were prescribed with full-time Lyon bracing. The minimum duration of follow-up was 24  months after the end of weaning (mean: 41.64        31.45  months). Anteroposterior radiographs were used to estimate the curve magnitude (CM) at 5 time points: beginning of treatment (t1), one year after the beginning of treatment (t2), intermediate time between t1 and t4 (t3), end of weaning (t4), 2-year minimum follow-up from t4 (t5). Three outcomes were distinguished: curve correction, curve stabilization and curve progression. RESULTS: The results from our study showed that of the 69 @entity0 with a definite outcome the CM mean value was 31.51          4.34 SD at @entity4          7.6 SD at t5. Curve correction was accomplished in 85.5  % of @entity0 , curve stabilization was obtained in 13  % of @entity0 and curve progression was evident in only 1.5  %. None of the @entity0 were recommended surgery post-bracing. Of 17 @entity0 who abandoned the treatment, at the time of abandonment (14.4 age) have achieved curve correction in 13 cases (77  %), stabilization in 53 cases (18  %) and progression in 1 case (5  %). CONCLUSION: The Lyon brace, through its biomechanical action on vertebral modeling, is highly effective in correcting thoracic curves in particularly when the SOSORT guidelines were adopted in addition to the @entity2 criteria.

title: Lyon bracing in adolescent females with XXXX : a prospective study based on @entity2 and SOSORT criteria.

answer: @entity1


abstract: BACKGROUND: The Lyon brace is commonly prescribed in many European countries to @entity0 with thoracic curves and is based on the three-point pressure system. The purpose of this study was to evaluate the efficacy of Lyon bracing for the conservative treatment of adolescent females with @entity1 in a case series selected on the basis of the @entity2 ( @entity2 ) Committee on Bracing and Nonoperative Management Standardization Criteria and followed the guidelines on management of @entity3 with corrective braces, proposed by the International Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT). METHODS: Prospective study based on an ongoing database. From 1297 @entity0 treated for @entity3 between 1995 and 2014 fulfill the inclusion criteria 102 @entity0 treated with Lyon brace. Of these, 69 @entity0 had a definite outcome, 17 have abandoned treatment e 16 are still in treatment. The 104 @entity0 were adolescent females with curvatures in the thoracic spine and a pre-treatment Risser score ranging from 0 to 2. All @entity0 were prescribed with full-time Lyon bracing. The minimum duration of follow-up was 24  months after the end of weaning (mean: 41.64        31.45  months). Anteroposterior radiographs were used to estimate the curve magnitude (CM) at 5 time points: beginning of treatment (t1), one year after the beginning of treatment (t2), intermediate time between t1 and t4 (t3), end of weaning (t4), 2-year minimum follow-up from t4 (t5). Three outcomes were distinguished: curve correction, curve stabilization and curve progression. RESULTS: The results from our study showed that of the 69 @entity0 with a definite outcome the CM mean value was 31.51          4.34 SD at @entity4          7.6 SD at t5. Curve correction was accomplished in 85.5  % of @entity0 , curve stabilization was obtained in 13  % of @entity0 and curve progression was evident in only 1.5  %. None of the @entity0 were recommended surgery post-bracing. Of 17 @entity0 who abandoned the treatment, at the time of abandonment (14.4 age) have achieved curve correction in 13 cases (77  %), stabilization in 53 cases (18  %) and progression in 1 case (5  %). CONCLUSION: The Lyon brace, through its biomechanical action on vertebral modeling, is highly effective in correcting thoracic curves in particularly when the SOSORT guidelines were adopted in addition to the @entity2 criteria.

title: Lyon bracing in adolescent females with @entity1 : a prospective study based on XXXX and SOSORT criteria.

answer: @entity2


abstract: PURPOSE: Urological chronic pelvic @entity1 syndromes have @entity3 as the dominant symptom. This has been attributed to changes in  the central nervous system caused by a chronic barrage of noxious stimuli. We  developed what is to our knowledge a novel challenge protocol that induced @entity2 in study @entity0 to reproduce @entity1 and urinary symptoms. We tested to see whether it could discriminate between @entity0 with urological chronic @entity4 and asymptomatic controls. MATERIALS AND METHODS: We recruited 10 female twin pairs who were discordant for urological chronic @entity4 . Before scanning each  twin urinated to completion and then consumed 500 cc water. Each twin was scanned with our resting state functional magnetic resonance imaging protocol immediately and approximately 50 minutes after consumption. Time series were extracted from the right and left periaqueductal gray, and the right and left amygdala subregions. We performed the repeated measures 2-sample t-test to assess differences in connectivity between symptomatic and asymptomatic twins before and after @entity2 . RESULTS: Group by condition interaction effects were found from the periaqueductal gray to the right cerebellum VIIIa, the amygdala, the right premotor cortex/supplementary motor area and the insular cortex, and between the amygdala and the frontal pole/medial orbital frontal cortex, the hypothalamus, the insular cortex, the thalamus and the anterior cingulate cortex. CONCLUSIONS: These findings demonstrate that our noninvasive @entity2 protocol can detect differences in the processing of urinary sensation between twins discordant for lower urinary tract @entity1 .

title: Alterations in Connectivity on Functional Magnetic Resonance Imaging with Provocation of Lower Urinary Tract Symptoms: A MAPP Research Network Feasibility Study of Urological Chronic Pelvic XXXX Syndromes.

answer: @entity1


abstract: UNASSIGNED: @entity1 and @entity2 adversely affect behavior though these conditions may be handled through environmental and dietary changes. Diet rich in @entity4 and @entity3 may support reducing @entity1 and @entity2 . @entity2 is most common but serious illness making life miserable; however the usage of dietary and herbal complements to treat @entity1 and @entity2 had been grown by the time. The purpose of this investigation was to characterize the behavioral properties of Citrus paradisi in @entity0 at diverse doses i.e. 0.1, 0.3 and 0.5  ml/kg. Anxiolytic and antidepressant actions were particularly measured twice in 15  days through elevated plus maze, open field and forced swimming tests. C. paradisi, revealed increase in the locomotor activity and the exploratory skills of the animals, as assessed in the open-field. Indeed C. paradisi had a strong anxiolytic effect in elevated plus-maze, as assessed by an augmented number of entries and the proportion of time spent in the open arms. Moreover there was decline in duration of immobility and rise in duration of climbing during forced swimming test. At the tested doses these results suggest that C. paradisi have the potential to exert a range of CNS-mediated biological activities and thus encourage more investigations in this field.

title: Behavioral effects of citrus paradisi in XXXX .

answer: @entity0


abstract: BACKGROUND: @entity2 is a major dairy starter used for manufacturing of dairy products. In the present study, we developed a @entity1 ( @entity1 ) scheme for this important food bacterium. Sequences of 10 housekeeping genes (carB, clpX, dnaA, murC, murE, pepN, pepX, pyrG, recA, and rpoB) were obtained for 239   @entity3 strains, which were isolated from home-made fermented dairy foods in 18 different regions of Mongolia and China. METHODS: All 10 genes of @entity3 were sequenced, aligned, and defined sequence types (STs) using the BioNumerics Software. The @entity0 diversity was calculated by START v2.0. The population structure, phylogenetic relationships and the role of recombination were inferred using ClonalFrame v1.2, SplitsTree 4.0 and Structure v2.3. RESULTS: The 239   @entity3 isolates and 18 reference strains could be assigned into 119 different STs, which could be further separated into 16 clonal complexes (CCs) and 38 singletons. Among the 10 loci, a total of 132 polymorphic sites were detected. The standardized index of association (I A (S)    =   0.0916), split-decomposition and   /   (relative frequency of occurrence of recombination and mutation) and r/m value (relative impact of recombination and mutation in the diversification) confirms that recombination may have occurred, but it occurred at a low frequency in these 10 loci. Phylogenetic trees indicated that there were five lineages in the @entity3 isolates used in our study. MSTree and ClonalFrame tree analyses suggest that the evolution of @entity3 isolates have little relationship with geographic locality, but revealed no association with the types of fermented dairy product. Phylogenetic analysis of 36 whole genome strains (18   @entity3 , 2   S. vestibularis and 16   @entity4 strains) indicated that our @entity1 scheme could clearly separate three closely related species within the salivarius group and is suitable for analyzing the population structure of the other two species in the salivarius group. CONCLUSIONS: Our newly developed @entity1 scheme improved the understanding on the genetic diversity and population structure of the @entity3 , as well as provided useful information for further studies on the genotyping and evolutionary research for @entity3 strains with global diversity.

title: Multilocus sequence typing of XXXX from naturally fermented dairy foods in China and Mongolia.

answer: @entity2


abstract: UNASSIGNED: We report here a rare case of @entity3 and @entity5 associated with @entity6 due to @entity4 . An 84-year-old male was referred to our hospital complaining of macrohematuria, fecaluria, pneumaturia and micturitional @entity2 . Computed tomography (CT) showed @entity6 . Other examinations, including colonoscopy and cystoscopy, did not reveal a clear cause for the @entity6 . Only an elevated serum level of the @entity0 marker CA19-9 suggested the possibility of @entity4 . Eleven days after hospitalization, bilateral scrotal contents had swollen rapidly to the size of a goose egg. CT suggested @entity3 with @entity5 formation. @entity5 and colostomy were performed. Intraoperatively, the @entity3 of the bulbar urethra was revealed. Because increased serum CA19-9 suggested a diagnosis of @entity4 , cystectomy and sigmoid colectomy with right nephrectomy were performed. Pathological examination revealed @entity7 with @entity1 . His condition was improved with rehabilitation 6 months after operation.

title: [Urethral Fistula and @entity5 Associated with @entity6 Due to the Sigmoid XXXX ].

answer: @entity4


abstract: UNASSIGNED: We report here a rare case of @entity3 and @entity5 associated with @entity6 due to @entity4 . An 84-year-old male was referred to our hospital complaining of macrohematuria, fecaluria, pneumaturia and micturitional @entity2 . Computed tomography (CT) showed @entity6 . Other examinations, including colonoscopy and cystoscopy, did not reveal a clear cause for the @entity6 . Only an elevated serum level of the @entity0 marker CA19-9 suggested the possibility of @entity4 . Eleven days after hospitalization, bilateral scrotal contents had swollen rapidly to the size of a goose egg. CT suggested @entity3 with @entity5 formation. @entity5 and colostomy were performed. Intraoperatively, the @entity3 of the bulbar urethra was revealed. Because increased serum CA19-9 suggested a diagnosis of @entity4 , cystectomy and sigmoid colectomy with right nephrectomy were performed. Pathological examination revealed @entity7 with @entity1 . His condition was improved with rehabilitation 6 months after operation.

title: [Urethral Fistula and XXXX Associated with @entity6 Due to the Sigmoid @entity4 ].

answer: @entity5


abstract: UNASSIGNED: We report here a rare case of @entity3 and @entity5 associated with @entity6 due to @entity4 . An 84-year-old male was referred to our hospital complaining of macrohematuria, fecaluria, pneumaturia and micturitional @entity2 . Computed tomography (CT) showed @entity6 . Other examinations, including colonoscopy and cystoscopy, did not reveal a clear cause for the @entity6 . Only an elevated serum level of the @entity0 marker CA19-9 suggested the possibility of @entity4 . Eleven days after hospitalization, bilateral scrotal contents had swollen rapidly to the size of a goose egg. CT suggested @entity3 with @entity5 formation. @entity5 and colostomy were performed. Intraoperatively, the @entity3 of the bulbar urethra was revealed. Because increased serum CA19-9 suggested a diagnosis of @entity4 , cystectomy and sigmoid colectomy with right nephrectomy were performed. Pathological examination revealed @entity7 with @entity1 . His condition was improved with rehabilitation 6 months after operation.

title: [Urethral Fistula and @entity5 Associated with XXXX Due to the Sigmoid @entity4 ].

answer: @entity6


abstract: The control of anterior pituitary hormone gene expression by @entity1 in male @entity0 pituitaries in vivo was investigated using dot-blot mRNA-cDNA hybridization assays. Common alpha subunit mRNA levels doubled by 2 days after orchidectomy and rose progressively to reach plateau levels three to four times intact control values by 2 weeks. @entity3 mRNA increased significantly (congruent to 50%) within 12 h, and thereafter progressively to seven times intact control values by 3 weeks after orchidectomy. The changes in alpha mRNA were likely to have occurred in gonadotrophs and not thyrotrophs, since @entity2 mRNA levels were unaltered by orchidectomy. LH subunit mRNA changes were accompanied by an initial (1-4 days) decrease in pituitary LH content; thereafter, pituitary LH increased in parallel with and by a similar magnitude to the @entity3 mRNA. Serum LH rises occurred before significant increases in LH subunit mRNA after orchidectomy. The lack of temporal correlation between mRNA levels and serum and pituitary LH in the early stages after removal of @entity1 feedback contrasts with the good correlation when a new steady state was achieved after 3-4 weeks, and indicates differing kinetics for changes in these aspects of gonadotroph function. An inhibitory effect of @entity1 on LH subunit gene expression was confirmed by prevention of the rise in alpha and @entity3 mRNAs when treatment commenced immediately after castration. However, pituitary LH content and serum LH levels were reduced relative to control values, suggesting additional inhibitory actions of @entity1 on translational and post-translational events in gonadotrophs.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Gonadal regulation of pituitary hormone mRNA levels in male XXXX .

answer: @entity0


abstract: @entity5 , or @entity5 , is a pathologically and clinically very inhomogeneous disease, the main features of which are @entity1 combined with deafness of varying degrees. Our experience with 18 @entity0 from 6 families demonstrates the variability in the manifestation of the clinical defect syndromes with @entity1 . In the majority of our cases, @entity2 was diagnosed. 7 @entity0 are undergoing chronic intermittent hemodialysis, and 4 @entity0 survive with a kidney transplant. Following kidney transplantation, histological changes in the sense of a recurrent @entity3 were demonstrated in some cases. The existence of prevailing histocompatibility antigen @entity6 serves as a clue to the possibility of an underlying @entity4 . We calculate a relative risk of 6.0. The HLA-D region controls the expression of surface antigens. They are responsible for the communication with lymphoid cells. Defect immune response genes in combination with missing reaction to autoantibodies against @entity3 may lead to an increase of susceptibility for the disease.

title: XXXX --an autoaggressive immunopathy?

answer: @entity5


abstract: @entity9 ( @entity9 ) is a rare syndrome with unknown pathogenesis. Data have shown a higher prevalence in female gender. We present a @entity0 with @entity7 and @entity6 and antitubular antibody. A 23-year-old @entity0 presented with a history of @entity1 , @entity5 , and @entity6 . His serum @entity4 was 2.1mg/d with @entity8 and @entity3 in urinalysis. Other laboratory and imaging studies were unremarkable. Kidney biopsy showed granulomatous @entity7 . Normal renal tissue specimen treated with patient's serum showed focal cytoplasmic staining in cortical tubular cells. The @entity0 received @entity2 for 1 month. @entity7 and @entity6 were well controlled. There was no recurrence in 1-year follow-up. We suggest that @entity7 and @entity6 should be considered in differential diagnosis of @entity0 with @entity7 and @entity6 . Antitubular antibody may be used as a diagnosis marker for this syndrome.

title: XXXX : report of a rare syndrome.

answer: @entity9


abstract: BACKGROUND: @entity5 ( @entity5 ) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo. Several reports indicated the presence of sRANKL in gingival crevicular fluid of @entity0 with @entity4 . OBJECTIVE: To determine the presence of @entity5 in peri-implant crevicular fluid samples of implants with @entity3 , @entity1 and healthy controls. METHODS: In this study, 40 implants were categorized as clinically healthy, @entity1 and @entity3 according to the clinical and radiographic findings. Filter paper strips were used to collect peri-implant crevicular fluid for 30 seconds in the base of the crevice/pocket. Peri-implant crevicular fluid (PICF) samples were obtained from buccal and lingual aspects of implants. Plaque index, probing depth, gingival index and @entity2 on probing were recorded at six sites per implant. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the PICF levels of sRANKL. RESULTS: There were no statistically significant differences in sRANKL concentration between healthy group, @entity1 and @entity3 (p=0.12). There were also no statistical correlation between the concentration of sRANKL and probing pocket depth (R=0.051, p=0.65), or any of the other clinical regarding (p>0.05). No differences between the mean sRANKL concentration in the buccal and lingual sites were found (p=0.693). CONCLUSION: Our results may suggest that peri-implant crevicular fluid analysis of sRANKL in conjunction with some other osteoclastogenic mediators could be further investigated in further well-designed prospective longitudinal studies on a larger-scale sample size in the evaluation of dental implants.

title: XXXX ( @entity5 ) levels in peri-implant crevicular fluid.

answer: @entity5


abstract: BACKGROUND: @entity5 ( @entity5 ) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo. Several reports indicated the presence of sRANKL in gingival crevicular fluid of @entity0 with @entity4 . OBJECTIVE: To determine the presence of @entity5 in peri-implant crevicular fluid samples of implants with @entity3 , @entity1 and healthy controls. METHODS: In this study, 40 implants were categorized as clinically healthy, @entity1 and @entity3 according to the clinical and radiographic findings. Filter paper strips were used to collect peri-implant crevicular fluid for 30 seconds in the base of the crevice/pocket. Peri-implant crevicular fluid (PICF) samples were obtained from buccal and lingual aspects of implants. Plaque index, probing depth, gingival index and @entity2 on probing were recorded at six sites per implant. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the PICF levels of sRANKL. RESULTS: There were no statistically significant differences in sRANKL concentration between healthy group, @entity1 and @entity3 (p=0.12). There were also no statistical correlation between the concentration of sRANKL and probing pocket depth (R=0.051, p=0.65), or any of the other clinical regarding (p>0.05). No differences between the mean sRANKL concentration in the buccal and lingual sites were found (p=0.693). CONCLUSION: Our results may suggest that peri-implant crevicular fluid analysis of sRANKL in conjunction with some other osteoclastogenic mediators could be further investigated in further well-designed prospective longitudinal studies on a larger-scale sample size in the evaluation of dental implants.

title: @entity5 ( XXXX ) levels in peri-implant crevicular fluid.

answer: @entity5


abstract: BACKGROUND: Asthma and @entity3 are among the most common diseases in the world. OBJECTIVE: The aim of this study was to detect, by skin prick test, aeroallergens in @entity1 @entity0 in Sari, Mazandaran in north of Iran. METHODS: This is a prospective study of skin prick test of aeroallergens in @entity2 , @entity3 and their combination with clinical diagnosis. Three hundred and seventy five cases aged between 5 to 50 years, were referred to Tooba and Boo-Ali @entity1 centers of Mazandaran University of Medical Sciences between December 2006 and July 2009. The aeroallergens studied included house dust mites ( @entity5 , @entity4 ), cockroaches, feather, aspergillus, Alternaria, pigweed, nettle, oak and maple. RESULTS: Of the studied individuals, 175 cases were males (46.7%) and 200 were females (53.3%), of which 156 (n=41.5%) reacted to allergen extracts. In @entity2 , @entity3 and their combination, the respective positive percentages were 26.6%, 22.9%, and 32.6% for @entity5 ; 26.6%, 25.3%, and 23.3% for @entity4 ; 12.7%, 17.4%, and 11.6% for cockroaches and 16.5%, 4.7%, and 7.0% for the feather. Other allergens were positive up to 5 percent. Total IgE levels were elevated in 56.4%, 53% and 60.5% of asthmatic, @entity3 and the combination group, respectively. Eosinophils count was elevated in 40.5%, 33.2% and 37.2% of the same groups, respectively. CONCLUSION: The @entity1 to house dust mites is very common in north of Iran which may be attributed to the warm and humid weather of this area.

title: XXXX to house dust mite and cockroach is the most common allergy in north of iran.

answer: @entity1


abstract: Fourteen @entity0 had mesenteric, portal, or @entity2 that was diagnosed primarily by contrast-enhanced CT. The group included five @entity0 with @entity11 , three with @entity12 , two with @entity3 and @entity4 , one with @entity10 , and one with @entity5 . In two @entity0 , no etiology was determined. In all cases, CT easily identified low-density @entity2 , which frequently involved more than one vein. In four @entity0 , all three splanchnic veins were involved; five @entity0 had occlusion of two veins. In five @entity0 , only one vein was involved. Additional CT findings included ascites, collateral veins, @entity7 , and @entity6 . No venous wall enhancement was found. CT also was helpful in defining the cause of @entity9 in six of 14 @entity0 . Mesenteric @entity1 and/or bowel wall thickening was not identified. None of the @entity0 had classic clinical evidence of @entity8 , and none died primarily of that disease. The major morbidity suffered by these @entity0 stemmed from complications of @entity8 , and nine @entity0 ultimately required sclerotherapy, splenectomy, and portal decompression. We conclude that CT is useful in the diagnosis of @entity2 . Our experience suggests that mesenteric, @entity2 may occur more commonly than has been previously thought and that the disease in many cases is not life threatening.

title: XXXX of the splanchnic veins: CT diagnosis.

answer: @entity9


abstract: UNASSIGNED: Long-term live cell imaging was used in this study to determine the responses of @entity0 epithelial cells to pathogenic biofilms formed by @entity1 . Epithelial cells of the skin represent the front line of defense against invasive pathogens such as @entity1 but under certain circumstances, especially when the host's immune system is compromised, the skin barrier is breached. The mechanisms by which the fungal pathogen penetrates the skin and invade the deeper layers are not fully understood. In this study we used keratinocytes grown in culture as an in vitro model system to determine changes in host cell migration and the actin cytoskeleton in response to virulence factors produced by biofilms of pathogenic @entity1 . It is clear that changes in epithelial cell migration are part of the response to virulence factors secreted by biofilms of @entity1 and the actin cytoskeleton is the downstream effector that mediates cell migration. Our goal is to understand the mechanism by which virulence factors hijack the signaling pathways of the actin cytoskeleton to alter cell migration and thereby invade host tissues. To understand the dynamic changes of the actin cytoskeleton during infection, we used long-term live cell imaging to obtain spatial and temporal information of actin filament dynamics and to identify signal transduction pathways that regulate the actin cytoskeleton and its associated proteins. Long-term live cell imaging was achieved using a high resolution, multi-mode epifluorescence microscope equipped with specialized light sources, high-speed cameras with high sensitivity detectors, and specific biocompatible fluorescent markers. In addition to the multi-mode epifluorescence microscope, a spinning disk confocal long-term live cell imaging system (Olympus CV1000) equipped with a stage incubator to create a stable in vitro environment for long-term real-time and time-lapse microscopy was used. Detailed descriptions of these two long-term live cell imaging systems are provided.

title: Long-Term Live Cell Imaging of Cell Migration: Effects of Pathogenic Fungi on XXXX Epithelial Cell Migration.

answer: @entity0


abstract: Between January and March 1984, the first community outbreak of transient @entity7 in the United States was documented in a seven-county area of southeastern Nebraska; 36 of the total 49 @entity0 resided in York County (2.4 cases per 1,000 population). The median age of @entity0 was 36 years, range six to 82 years; 51 percent were @entity0 . By definition, all @entity0 were symptomatic, visited a physician, and had a newly identified elevated serum concentration of @entity6 or @entity5 of unknown cause. None had a @entity8 or a @entity1 . Low 131I uptake measurements were found in all nine @entity0 studied. Six @entity0 were hospitalized; none died. Investigation of all 12 household contacts of eight selected @entity0 revealed five additional @entity0 with @entity7 and four with asymptomatic @entity9 . A case-control study revealed that illness was associated with a significantly higher frequency of a @entity4 . In another case-control study, the HLA-DR3 antigen was present in more case subjects (39 percent) than control subjects (14 percent). In addition, a significantly higher proportion of @entity0 than control subjects purchased beef from one of the three supermarkets in York Country. Concomitant with the outbreak, the supermarket implicated in the outbreak purchased an unusually large quantity of beef (7,000 pounds) from a nonregular supplier in Nebraska, which had reportedly instituted the practice of trimming gullets (a procedure that removes the muscles from @entity2 larynx for beef) about three months earlier. Thus, it is concluded that the Nebraska outbreak, like one in Minnesota that occurred 18 months later, probably resulted from @entity0 having eaten ground beef that was contaminated with @entity2 thyroid gland. This form of @entity7 , perhaps misdiagnosed as @entity3 in the past, probably represents a previously under-recognized public health problem.

title: Community outbreak of XXXX : epidemiology, immunogenetic characteristics, and long-term outcome.

answer: @entity7


abstract: BACKGROUND: Public health is increasingly concerned with recognising factors that lead to sex differences in @entity2 . We conducted a study to determine the effect of sex on knowledge of @entity2 risk factors and warning signs, and how both are perceived, in a representative sample of adults. METHODS: A representative sample of the population of Extremadura, Spain was selected using a double randomisation technique. Previously trained medical students carried out face-to-face interviews using a structured questionnaire. RESULTS: 2409 subjects were interviewed [59.9  % @entity0 ; mean age (SD) 49.0 (18.7) years]. Seventy-three percent of all subjects reported at least one correct warning sign of @entity2 (OR: 1.01; 95  % CI: 0.84-1.21). The most frequently mentioned warning signs were @entity5 , @entity6 , and @entity1 . There were no sex differences regarding the types of warning symptoms that respondents listed. @entity0 displayed better knowledge of risk factors than @entity0 (OR: 1.23; 95  % CI: 1.05-1.46). @entity0 were more likely to name @entity3 as a risk factor for @entity2 whereas @entity0 more frequently listed smoking, @entity4 consumption and a sedentary lifestyle as risk factors. In response to @entity2 , @entity0 were significantly less likely than @entity0 to choose to call an ambulance or to go immediately to hospital (OR: 0.69; 95  % CI: 0.60-0.85). CONCLUSIONS: @entity2 knowledge is suboptimal in both @entity0 and @entity0 . We detected better knowledge of @entity2 risk factors in @entity0 , as well as differences in the type of risk factors listed by @entity0 and @entity0 . There were significant sex differences regarding response to @entity2 or to its warning signs.

title: Knowledge of XXXX a study from a sex perspective.

answer: @entity2


abstract: Our experience of radical nephrectomy was analyzed and recent management of @entity3 was reviewed. One hundred forty-eight @entity0 with @entity3 were treated by radical nephrectomy between 1970 and December, 1986. The 5-year survival rate according to pathological @entity2 was 100% for 4 @entity0 in @entity5 , 73% for 85 @entity0 in pT2, 51% for 54 @entity0 in @entity4 , and 0% for 5 @entity0 in pT4. Four @entity0 in @entity5 had no venous involvement, lymph node @entity1 , or distant @entity1 . Thirty @entity0 had venous involvement, 8 in pT2, 20 in @entity4 and 2 in pT4. Seventeen @entity0 had positive lymph nodes, 0 in pT2, 15 in @entity4 and 2 in pT4. Thirty-three @entity0 had distant @entity1 at the time of nephrectomy, 12 in pT2, 18 in @entity4 and 3 in pT4. The 5-year survival rates of 30 @entity0 with venous involvement, 17 with lymph node @entity1 and 33 with distant @entity1 were 47%, 30% and 37%, respectively. No anti- @entity2 drugs have been recognized to be effective for @entity3 . However, recent experiences with interferon and lymphokine-activated killer cell therapy suggest that immunotherapy may have a potential role in the management of @entity3 .

title: [Recent management of XXXX ].

answer: @entity3


abstract: OBJECTIVE: To explore the clinicopathological characteristics and prognosis of @entity3 @entity0 with extremely elevated serum carcinoembryonic antigen( @entity5 ) level before operation(>50  g/L). METHODS: Clinicopathological and follow-up data of 1250 @entity0 with @entity3 undergoing @entity2 resection between January 2001 and December 2011 were retrospectively analyzed. All the @entity0 were divided into three groups according to the preoperative serum @entity5 levels as normal group (0-5  g/L, 721 cases), elevated group(5-50  g/L, 408 cases) and extremely elevated(>50  g/L, 121 cases). Kaplan-Meier method was used to analyze the overall survival and disease-free survival. Log-rank test was used to compare the survival between groups. Cox regression was used to screen the independent prognostic factors of @entity3 . RESULTS: Compared with normal and elevated groups, @entity0 with extremely elevated @entity5 had more @entity4 ,N,M stages (P<0.01), more palliative surgery (P<0.01) and more lymphovascular invasion(P<0.01). During the follow-up, @entity0 with extremely elevated @entity5 demonstrated significantly higher ratio of distant @entity1 and liver @entity1 (both P=0.001). After radical surgery, 5-year overall survival rate of @entity0 with normal, elevated and extremely elevated @entity5 levels was 70.1%, 54.4% and 42%, respectively, with statistically significant difference among three groups (P<0.001). Multivariate analysis showed that @entity2 differentiation, TNM staging, preoperative @entity5 levels, lymphovascular invasion and adjuvant chemotherapy were independent prognostic factors for @entity3 (all P<0.01). CONCLUSIONS: @entity3 @entity0 with extremely elevated preoperative @entity5 levels are associated with more unfavorable pathological factors, advanced TNM stage and more distant @entity1 (especially the liver @entity1 ) during the follow-up. The elevated degree of preoperative @entity5 level is an independent poor prognostic factor of @entity0 with @entity3 .

title: [Clinical characteristics and prognosis of XXXX @entity0 with extremely elevated carcinoembryonic antigen level].

answer: @entity3


abstract: OBJECTIVE: To explore the clinicopathological characteristics and prognosis of @entity3 @entity0 with extremely elevated serum carcinoembryonic antigen( @entity5 ) level before operation(>50  g/L). METHODS: Clinicopathological and follow-up data of 1250 @entity0 with @entity3 undergoing @entity2 resection between January 2001 and December 2011 were retrospectively analyzed. All the @entity0 were divided into three groups according to the preoperative serum @entity5 levels as normal group (0-5  g/L, 721 cases), elevated group(5-50  g/L, 408 cases) and extremely elevated(>50  g/L, 121 cases). Kaplan-Meier method was used to analyze the overall survival and disease-free survival. Log-rank test was used to compare the survival between groups. Cox regression was used to screen the independent prognostic factors of @entity3 . RESULTS: Compared with normal and elevated groups, @entity0 with extremely elevated @entity5 had more @entity4 ,N,M stages (P<0.01), more palliative surgery (P<0.01) and more lymphovascular invasion(P<0.01). During the follow-up, @entity0 with extremely elevated @entity5 demonstrated significantly higher ratio of distant @entity1 and liver @entity1 (both P=0.001). After radical surgery, 5-year overall survival rate of @entity0 with normal, elevated and extremely elevated @entity5 levels was 70.1%, 54.4% and 42%, respectively, with statistically significant difference among three groups (P<0.001). Multivariate analysis showed that @entity2 differentiation, TNM staging, preoperative @entity5 levels, lymphovascular invasion and adjuvant chemotherapy were independent prognostic factors for @entity3 (all P<0.01). CONCLUSIONS: @entity3 @entity0 with extremely elevated preoperative @entity5 levels are associated with more unfavorable pathological factors, advanced TNM stage and more distant @entity1 (especially the liver @entity1 ) during the follow-up. The elevated degree of preoperative @entity5 level is an independent poor prognostic factor of @entity0 with @entity3 .

title: [Clinical characteristics and prognosis of @entity3 XXXX with extremely elevated carcinoembryonic antigen level].

answer: @entity0


abstract: We report two cases of @entity5 . Case 1 is a 66-year-old @entity0 whose left eye was enucleated about one month after onset of @entity1 . Ophthalmoscopic examination disclosed multiple choroidal masses. Six weeks before the onset of ocular manifestations he had undergone a prolonged carotid endarterectomy with intraoperative complications. The source of the @entity6 was probably exogenous. Case 2 is a 49-year-old @entity0 who had @entity3 ( @entity4 ) with severe @entity2 . She had received moderate doses of corticosteroids. Seventeen months after initiation of therapy she developed ocular manifestations leading to enucleation of the eye one month later. Histopathologically, the enucleated eyes in both cases showed numerous branching, Gram-positive, filamentous organisms involving mainly the plane of Bruch's membrane and the subretinal space. The nosological and microbiological aspects of @entity7 are reviewed.

title: XXXX : report of two cases studied histopathologically.

answer: @entity5


abstract: BACKGROUND: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of @entity1 has been realized. This study aimed to identify a novel biomarker for @entity2 ( @entity2 ). METHODS: The expression profiles of @entity1 cells in 152 @entity0 with stage I-III @entity2 were examined using microarray analysis. High expression in @entity2 cells, especially in @entity0 with distant recurrences, was a prerequisite to select candidate genes. Thus, we identified seventeen candidate genes, and selected @entity3 - and Nck-interacting kinase ( @entity4 ), which was known to be associated with progression in @entity2 through Wnt signaling pathways. We analyzed the protein expression of @entity4 using immunohistochemistry (IHC) and investigated the relationship between protein expression and @entity0 characteristics in 220 stage I-III @entity2 @entity0 . RESULTS: Relapse-free survival was significantly worse in the @entity4 high expression group than in the @entity4 low expression group in stage II (p   =   0.028) and stage III (p   =   0.006) @entity0 . In multivariate analysis, high @entity4 expression was identified as a significant independent risk factor of distant recurrence in stage III @entity0 . CONCLUSION: This study is the first to demonstrate the prognostic significance of intratumoral @entity4 protein expression in clinical tissue samples of @entity2 , in that high expression of @entity4 protein in primary @entity1 was associated with distant recurrence in stage II and III @entity2 @entity0 . This @entity4 IHC study might contribute to practical decision-making in the treatment of these @entity0 .

title: Prognostic significance of Traf2- and Nck- interacting kinase ( @entity4 ) in XXXX .

answer: @entity2


abstract: BACKGROUND: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of @entity1 has been realized. This study aimed to identify a novel biomarker for @entity2 ( @entity2 ). METHODS: The expression profiles of @entity1 cells in 152 @entity0 with stage I-III @entity2 were examined using microarray analysis. High expression in @entity2 cells, especially in @entity0 with distant recurrences, was a prerequisite to select candidate genes. Thus, we identified seventeen candidate genes, and selected @entity3 - and Nck-interacting kinase ( @entity4 ), which was known to be associated with progression in @entity2 through Wnt signaling pathways. We analyzed the protein expression of @entity4 using immunohistochemistry (IHC) and investigated the relationship between protein expression and @entity0 characteristics in 220 stage I-III @entity2 @entity0 . RESULTS: Relapse-free survival was significantly worse in the @entity4 high expression group than in the @entity4 low expression group in stage II (p   =   0.028) and stage III (p   =   0.006) @entity0 . In multivariate analysis, high @entity4 expression was identified as a significant independent risk factor of distant recurrence in stage III @entity0 . CONCLUSION: This study is the first to demonstrate the prognostic significance of intratumoral @entity4 protein expression in clinical tissue samples of @entity2 , in that high expression of @entity4 protein in primary @entity1 was associated with distant recurrence in stage II and III @entity2 @entity0 . This @entity4 IHC study might contribute to practical decision-making in the treatment of these @entity0 .

title: Prognostic significance of Traf2- and Nck- interacting kinase ( XXXX ) in @entity2 .

answer: @entity4


abstract: UNASSIGNED: The data of factors on the changes in survival before and after the introduction of @entity5 in unselected @entity4 ( @entity4 ) @entity0 is scarce in Asian population. We analyzed the clinical features and treatment outcomes of 270 consecutive @entity4 @entity0 admitted to our hospital between January 1995 and August 2014. The @entity0 were divided into two groups, 1995-2005 (n   =   106) and 2006-2014 (n   =   164), based on @entity5 availability. There were no differences in baseline characteristics between the groups, except age and percentage of @entity0 receiving autologous stem cell transplantation (auto- @entity6 ). The proportion of @entity0 obtaining >= very good partial response (VGPR) was higher in the recent cohort, which was translated as better overall survival in both younger and older @entity0 (36.1 vs. 79.8  months, P   =   0.024, and 40.0 vs. 110.7  months, respectively). @entity0 receiving @entity5 early after diagnosis showed significantly better survival. However, there was no difference in survival between @entity0 obtaining >= VGPR in the two groups. On multivariate analysis, age >= 75 and @entity2 dehydrogenase (LDH) >normal were associated with shorter survival, while early @entity5 use and auto- @entity6 were associated with longer survival. On Cox regression analysis, @entity1 ( @entity1 ) stage III, LDH, and treatment response <VGPR in the previous cohort and @entity1 stage III, @entity3 >= 2.0  mg/dL, and treatment response <VGPR in the recent cohort were associated with poorer survival. Our observations indicated marked improvement of survival in @entity4 @entity0 diagnosed from 2006 to 2014 mainly due to the availability of @entity5 in Japan.

title: Changes in survival rate of @entity4 after the introduction of XXXX : a single institutional experience over 20  years.

answer: @entity5


abstract: UNASSIGNED: The data of factors on the changes in survival before and after the introduction of @entity5 in unselected @entity4 ( @entity4 ) @entity0 is scarce in Asian population. We analyzed the clinical features and treatment outcomes of 270 consecutive @entity4 @entity0 admitted to our hospital between January 1995 and August 2014. The @entity0 were divided into two groups, 1995-2005 (n   =   106) and 2006-2014 (n   =   164), based on @entity5 availability. There were no differences in baseline characteristics between the groups, except age and percentage of @entity0 receiving autologous stem cell transplantation (auto- @entity6 ). The proportion of @entity0 obtaining >= very good partial response (VGPR) was higher in the recent cohort, which was translated as better overall survival in both younger and older @entity0 (36.1 vs. 79.8  months, P   =   0.024, and 40.0 vs. 110.7  months, respectively). @entity0 receiving @entity5 early after diagnosis showed significantly better survival. However, there was no difference in survival between @entity0 obtaining >= VGPR in the two groups. On multivariate analysis, age >= 75 and @entity2 dehydrogenase (LDH) >normal were associated with shorter survival, while early @entity5 use and auto- @entity6 were associated with longer survival. On Cox regression analysis, @entity1 ( @entity1 ) stage III, LDH, and treatment response <VGPR in the previous cohort and @entity1 stage III, @entity3 >= 2.0  mg/dL, and treatment response <VGPR in the recent cohort were associated with poorer survival. Our observations indicated marked improvement of survival in @entity4 @entity0 diagnosed from 2006 to 2014 mainly due to the availability of @entity5 in Japan.

title: Changes in survival rate of XXXX after the introduction of @entity5 : a single institutional experience over 20  years.

answer: @entity4


abstract: Second-look surgery is used in restaging @entity0 with @entity2 to define sites of recurrence, plan therapy, and perform @entity1 debulking. We evaluated the role of CT in detecting residual or recurrent @entity1 in 55 @entity0 in whom 64 abdominopelvic CT scans were obtained. Forty-eight @entity0 underwent a second-look operation, and eight of these @entity0 had an additional third-look operation. CT correctly identified 17 (85%) of 20 cases with residual or recurrent pelvic disease and three (75%) of four cases with bulky @entity5 . CT failed to detect @entity1 in any of the five cases with minimal @entity3 and was able to detect @entity4 in only two (8%) of 24 cases. In four cases, CT detected pelvic disease not identified on clinical pelvic examination. On the 56 scans in 48 @entity0 with surgical proof (280 surgical findings), CT had a sensitivity of 40% (22/55) and a specificity of 99% (224/225). In seven additional @entity0 , second-look laparotomy was canceled because of CT findings of extensive, unresectable @entity1 . We conclude that CT provided valuable information regarding residual or recurrent @entity1 prior to second- and third-look surgery. In selective cases, CT findings obviated unnecessary surgery. However, the CT's lack of sensitivity in identifying minimal @entity3 and @entity4 precludes its use as a substitute for second-look surgery.

title: CT prior to second-look operation in XXXX .

answer: @entity2


abstract: BACKGROUND: It has been demonstrated that cognitive behavioural therapy (CBT) has a moderate effect on symptom reduction and on general well being of @entity0 suffering from @entity1 . However, questions regarding the specific efficacy of CBT, the treatment safety, the cost-effectiveness, and the moderators and mediators of treatment effects are still a major issue. The major objective of this trial is to investigate whether CBT is specifically efficacious in reducing positive symptoms when compared with non-specific supportive therapy (ST) which does not implement CBT-techniques but provides comparable therapeutic attention. METHODS/DESIGN: The POSITIVE study is a multicenter, prospective, single-blind, parallel group, randomised clinical trial, comparing CBT and ST with respect to the efficacy in reducing positive symptoms in @entity2 . CBT as well as ST consist of 20 sessions altogether, 165 @entity0 receiving CBT and 165 @entity0 receiving ST. Major methodological aspects of the study are systematic recruitment, explicit inclusion criteria, reliability checks of assessments with control for rater shift, analysis by intention to treat, data management using remote data entry, measures of quality assurance (e.g. on-site monitoring with source data verification, regular query process), advanced statistical analysis, manualized treatment, checks of adherence and competence of therapists. Research relating the psychotherapy process with outcome, neurobiological research addressing basic questions of delusion formation using fMRI and neuropsychological assessment and treatment research investigating adaptations of CBT for adolescents is combined in this network. Problems of transfer into routine clinical care will be identified and addressed by a project focusing on cost efficiency. DISCUSSION: This clinical trial is part of efforts to intensify psychotherapy research in the field of @entity1 in Germany, to contribute to the international discussion on psychotherapy in @entity2 , and to help implement psychotherapy in routine care. Furthermore, the study will allow drawing conclusions about the mediators of treatment effects of CBT of @entity2 .

title: Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in XXXX : the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial.

answer: @entity2