abstract: UNASSIGNED: Various environmental stresses limit plant growth, development, and reproductive success. Plants have therefore evolved sophisticated adaptive responses to deal with environmental challenges. The responses of plants to environmental stresses are mainly mediated by @entity1 ( @entity2 )-dependent and @entity2 -independent signaling pathways. While these two pathways have been implicated to play discrete roles in abiotic stress responses, accumulating evidence suggests that they are also intertwined. Here, we report that an R2R3-type MYB transcription factor, @entity4 , integrates the @entity2 and cold signaling pathways. In addition to its role in @entity2 -mediated drought responses, @entity4 is also induced by cold stress in an @entity2 -independent manner and subsequently activates freezing tolerance. Notably, @entity4 regulates @entity0 ( @entity0 ) genes by binding to their promoters. The @entity0 proteins, in turn, interact with C-REPEAT BINDING FACTOR (CBF) upstream regulators, such as @entity5 ( @entity5 ), @entity6 , and @entity3 ( @entity3 ). The specific interactive networks of HHPs with the CBF upstream regulators are necessary to facilitate transcriptional activation of the CBF regulon under stressful conditions. Together, the @entity4 - @entity0 module integrates @entity2 -dependent and @entity2 -independent signals and activates the CBF pathway, ensuring plant adaptation to a wide range of adverse environmental fluctuations.

title: The @entity4 - XXXX module integrates cold and @entity1 signaling to activate the CBF-COR pathway in Arabidopsis.

answer: @entity0


abstract: BACKGROUND: Retama raetam (RR) fruit is used in traditional Saudi folk medicine as a hypoglycemic herb. However, the potential @entity2 of RR has not been fully investigated. The current study aimed to explore the potential acute and subacute @entity2 of the methanolic extract of RR fruit in male and female @entity0 . METHODS: The extent of acute @entity2 of RR was tested 14 days after a single oral dose was administered (250  mg/kg, 500  mg/kg, or 750  mg/kg). Additionally, subacute @entity2 was tested 28 days after an oral dose of 250  mg/kg/d, 500  mg/kg/d, or 750  mg/kg/d was administered for 4 weeks. RESULTS: Subsequent to variable dosage testing, oral LD50 of RR was found to be 1995  mg/kg in @entity0 . Oral doses of 500  mg/kg and 750  mg/kg significantly decreased body @entity4 . Subacute administration (750  mg/kg) was associated with significant manifestations of @entity2 . Additionally, subacute administration of the extract at doses of 500  mg/kg or 750  mg/kg significantly elevated @entity5 transaminase and aspartate transaminase activities. Hepatotoxicity of RR was confirmed with histopathological findings. Subacute administration of RR (500  mg/kg) showed histopathological changes in the liver as indicated by degenerated hepatocytes and early @entity1 , while a dosage of 750  mg/kg showed congested central vein and @entity3 . Moreover, subacute administration of the extract at doses of 250  mg/kg, 500  mg/kg, or 750  mg/kg showed histopathological alterations in @entity0 kidney that ranged from mild interstitial congestion to @entity3 . The extract showed positive result in the Ames test. CONCLUSION: Repeated administration of methanolic extract of RR (250  mg/kg) has a low nephrotoxic subacute @entity2 potential, while it might have hepatotoxic, nephrotoxic, and mutagenic effects at higher doses.

title: Assessment of acute and subacute toxic effects of the Saudi folk herb Retama raetam in XXXX .

answer: @entity0


abstract: BACKGROUND/PURPOSE: Intravenous thrombolysis for @entity1 saves societal costs. The aim of this study was to investigate the cost burden that hospitals may shoulder. METHODS: @entity0 code activations between May 2009 and April 2011 were recorded and divided into groups based on work and duty time, as well as the period of the day or season. "Time cost of nonclosing service" (TCNS) per @entity0 code activation or intravenous thrombolysis treatment was calculated by dividing the time by the number of activations or thrombolysis treatments during that period. Comparisons were made among groups. RESULTS: There were a total of 634 @entity0 code activations in a period of 2  years, and intravenous thrombolysis was used in 132 (20.8%) of these cases. The rates of thrombolysis were not statistically different between the groups. Overall, the average TCNS for the @entity0 team was 27.6  hours per code activation and 132.7  hours per thrombolysis treatment. The TCNS during duty time was 1.38 times that during work time per @entity0 code activation and 1.46 times per thrombolysis treatment. In summer, the TCNS was 1.6 times that in winter per code activation and 2.2 times per thrombolysis treatment. During the late night hours, the TCNS was four times that of early night hours per code activation and 9.8 times per thrombolysis treatment. CONCLUSION: Our results demonstrate a large variation in the time cost of a nonclosing service for intravenous thrombolysis. Payment based on piece-rate compensation may not be appropriate and requires improvement.

title: Time cost of a nonclosing intravenous thrombolysis service for acute XXXX .

answer: @entity1


abstract: OBJECTIVE: @entity1 , occurring days after surgery, is associated with both short- and long-term adverse events. Postanesthesia care unit (PACU) @entity2 , immediately after recovery from anesthesia, is associated with continued @entity2 in the succeeding days and adverse cognitive outcomes at discharge. Longer-term consequences are unclear. The objective was to evaluate 18-month outcomes of @entity0 with versus without @entity2 in the PACU after surgery with general anesthesia. METHODS: In a prospective, observational, cohort study, 91 consecutive English-speaking @entity0 , aged at least 70 years and capable of independently providing informed consent before surgery, were followed after admission for a surgical procedure in one teaching hospital. @entity0 completed cognitive testing before surgery. After recovery from general anesthesia, they were evaluated for a DSM-IV diagnosis of @entity2 . @entity0 or proxies were evaluated, at a median of 19 months after surgery (interquartile range: 18-20 months), for survival, cognitive and physical functioning, and healthcare utilization outcomes. RESULTS: All 91 @entity0 or proxies (41 with @entity2 [45%]) were contacted at follow-up, with 7 deaths (8%) and 3 declining further participation (3%); 81 (96% of survivors) completed follow-up evaluations, demonstrating no significant cognitive or functional decline from baseline, with 75% of the cohort living independently in the community, and no differences in any outcomes between @entity0 with versus without PACU @entity2 . CONCLUSION: In a small cohort of older @entity0 evaluated 18 months after surgery, we could not detect an association of @entity2 diagnosed in the PACU with @entity0 survival, cognitive/physical functioning, and healthcare utilization.

title: Long-Term Outcomes of Older Adults with and Without XXXX Immediately After Recovery from General Anesthesia for Surgery.

answer: @entity2


abstract: I prospectively studied 100 @entity0 to see whether "incidental appendectomy" with cholecystectomy affects wound @entity1 rate. Randomization resulted in groups similar in age, habitus, and sex. Forty-seven @entity0 had appendectomy. The most frequent @entity2 was chronic @entity3 . Positive cultures were obtained from 11% of gallbladders. The mean age of @entity0 with gallbladder bacteria was 14.5 years older than that of the series. True pathologic changes were seen in 6% of appendices. Average operative time was extended six minutes by appendectomy. Length of postoperative hospital stay was unchanged by the addition of appendectomy. There were no infections in the @entity0 without appendectomy and one (2%) in the group with appendectomy. The total 1% @entity1 rate is considerably below most reported rates. There was no difference in @entity1 rate between groups with and without appendectomy (P = .47). Unless the procedure is technically difficult, appendectomy with elective cholecystectomy does not increase the chance of @entity1 .

title: Prospective analysis of the effect of incidental appendectomy on XXXX rate after cholecystectomy.

answer: @entity1


abstract: The aim of the study was to present the trend as regards @entity2 in Norway since 1950, on the basis of data on incidence and mortality in the total population and @entity1 rate among pupils leaving primary school. The decline in incidence continued until the late 1980s. While the decline was 11% per year during the period 1950-74, it has been slower in recent years. In 1990-92 the incidence level was somewhat higher than in 1989, but figures for 1993-94 indicate a new decline. Mortality declined more slowly after the mid-1970s; a similar trend is found for prevalence of @entity1 among pupils. The incidence is among the lowest in Europe. The proportion of cases among immigrants increased gradually from 4% in 1977 to 40% in 1993. Among the Norwegian-born population the incidence rate of @entity3 has shown a steady decline, also during the last decades. Norwegian-born cases are mainly elderly @entity0 infected many decades ago. @entity1 is probably rare, and the proportion of infected @entity0 is gradually declining.

title: [ XXXX trends in Norway--has the decline stopped?].

answer: @entity2


abstract: The characteristics of @entity8 in Africa differ sharply from those in North America with respect to diagnosis and epidemiology, and in a clinical sense. The study of 78 @entity0 treated in Kinshasa, Zaire during the period of October 1983-July 1984 yielded the following results: 159 out of a total of 1051 hospitalized @entity0 were suspected of having @entity8 , and there were 78 proven cases (54 of them died). The average age of 40 @entity0 and 38 @entity0 was 27 and 31 years, respectively, and the ratio of married @entity0 was 35% and 74%, respectively, with a lot of @entity0 living in polygamous relationships. In the first stage of the disease weight loss appeared in 100%, recurrent @entity4 in 83.3%, significant loss of strength in 75.6%, febrile conditions in 68.3%, and @entity2 in 58.9%. The ratio of @entity0 to @entity0 was 5:5, since heterosexuality and polygamy prevailed. Cigarette smoking was the main addition, thus drug addition per se did not appear as a risk factor. Blood transfusions occurred frequently (for instance, in @entity5 ), but hemophilic @entity0 receiving lyophilized preparations were rare. Haitians visited in fairly large numbers after the 1960's propagating the risk of @entity8 . Black Africans accounted for 100% of cases. The number of concomitant, opportunistic diseases in @entity8 @entity0 in Zaire were: 34 cases of @entity7 , 32 cases of @entity15 , 30 @entity6 , 21 @entity13 and/or genitalis, 19 cases of dermal and @entity10 , 12 cases of @entity18 , 9 cases of @entity11 , 5 cases of @entity14 , 3 cases of @entity3 , 3 cases of @entity16 , 2 cases of @entity12 , and 1 case of @entity1 ( @entity19 ). @entity7 , @entity9 , @entity18 , and @entity17 were more frequent opportunistic diseases in Zaire than in the U.S.A., while @entity1 caused by @entity19 and @entity11 were relatively rare.

title: [Acquired immunodeficiency syndrome ( XXXX ) in the African environment].

answer: @entity8


abstract: INTRODUCTION: @entity6 ( @entity6 ) are among major causes of mortality in @entity0 with @entity4 . @entity1 develop either during the empirical antibiotic therapy or one week after cessation of therapy for a FNE. The aim of the study was to investigate the risk factors associated with secondary infections in febrile neutropenic @entity0 . METHODS: We retrospectively analyzed 750 @entity6 in 473 @entity0 between January 2000 and December 2006. RESULTS: @entity1 were diagnosed in 152 (20%) of 750 @entity6 . The median time to develop secondary infection was 10 days (range 2-34 days). The duration of @entity3 over 10 days significantly increased the risk of secondary infections (p<0.001). The proportion of @entity0 with microbiologically documented infections was found to be higher in primary infections (271/750, 36%) compared to secondary infections (43/152, 28%) (p=0.038). Age, sex, underlying disease, antibacterial, antifungal or antiviral prophylaxis, blood transfusion or bone marrow transplantation, central venous catheter or severity of @entity3 did not differ significantly between primary and secondary infections (p>0.05) While fever of unknown origin (FUO) (p=0.005) and catheter-related @entity5 (p<0.001) were less frequently observed in secondary infections, the frequency of microbiologically (p=0.003) and clinically (p<0.001) documented infections, @entity2 (p<0.001), infections related with gram positive bacteria (p=0.04) and fungi (p<0.001) and 30-day mortality rate (p<0.001) were significantly higher in secondary infections (p<0.001). DISCUSSION AND CONCLUSION: @entity1 should be regarded as life-threatening complications of @entity3 . @entity1 represent a more severe and mortal complication and cannot be regarded just as another febrile neutropenic episode.

title: Secondary Infections in XXXX in @entity4 : More Than Another Febrile Neutropenic Episode.

answer: @entity3


abstract: INTRODUCTION: @entity6 ( @entity6 ) are among major causes of mortality in @entity0 with @entity4 . @entity1 develop either during the empirical antibiotic therapy or one week after cessation of therapy for a FNE. The aim of the study was to investigate the risk factors associated with secondary infections in febrile neutropenic @entity0 . METHODS: We retrospectively analyzed 750 @entity6 in 473 @entity0 between January 2000 and December 2006. RESULTS: @entity1 were diagnosed in 152 (20%) of 750 @entity6 . The median time to develop secondary infection was 10 days (range 2-34 days). The duration of @entity3 over 10 days significantly increased the risk of secondary infections (p<0.001). The proportion of @entity0 with microbiologically documented infections was found to be higher in primary infections (271/750, 36%) compared to secondary infections (43/152, 28%) (p=0.038). Age, sex, underlying disease, antibacterial, antifungal or antiviral prophylaxis, blood transfusion or bone marrow transplantation, central venous catheter or severity of @entity3 did not differ significantly between primary and secondary infections (p>0.05) While fever of unknown origin (FUO) (p=0.005) and catheter-related @entity5 (p<0.001) were less frequently observed in secondary infections, the frequency of microbiologically (p=0.003) and clinically (p<0.001) documented infections, @entity2 (p<0.001), infections related with gram positive bacteria (p=0.04) and fungi (p<0.001) and 30-day mortality rate (p<0.001) were significantly higher in secondary infections (p<0.001). DISCUSSION AND CONCLUSION: @entity1 should be regarded as life-threatening complications of @entity3 . @entity1 represent a more severe and mortal complication and cannot be regarded just as another febrile neutropenic episode.

title: Secondary Infections in @entity3 in XXXX : More Than Another Febrile Neutropenic Episode.

answer: @entity4


abstract: OBJECTIVE: Investigate the impact of socioeconomic status and other demographic variables on adherence to the National @entity3 treatment guidelines among @entity0 with stage I/II disease. METHODS: @entity0 diagnosed with @entity3 between 1/1/96-12/31/06 were identified from the California @entity1 Registry. Univariate analysis and multivariate logistic regression models were used to evaluate differences in surgical procedures, chemotherapy regimens, and overall adherence to the NCCN guidelines according to increasing SES quintiles ( @entity4 to SES-5). RESULTS: A total of 5445 stage I and II @entity0 were identified. The median age at diagnosis was 54.0years (range=18-99years); 72.5% of @entity0 had stage I disease, while 27.5% had @entity2 . With a median follow-up time of 5years, the 5-year @entity3 -specific survival for all @entity0 was 82.7% (SE=0.6%). Overall, 23.7% of @entity0 received care that was adherent to the NCCN guidelines. Compared to @entity0 in the highest SES quintile (SES-5), @entity0 in the lowest SES quintile ( @entity4 ) were significantly less likely to receive proper surgery (27.3% vs 47.9%, p<0.001) or chemotherapy (42.4% vs 53.6%, p<0.001). There were statistically significant trends between increasing SES and the likelihood of overall treatment plan adherence to the NCCN guidelines: @entity4 =16.4%, @entity5 =19.0%, @entity6 =22.4%, SES-4=24.2% and SES-5=31.6% (p<0.001). Multivariate logistic regression analysis revealed that compared to SES-5, decreasing SES was independently predictive of a higher risk of non-standard overall care. CONCLUSIONS: For @entity0 with @entity3 , low SES is a significant and independent predictor of deviation from the NCCN guidelines for surgery, chemotherapy, and overall treatment.

title: Socioeconomic status as a predictor of adherence to treatment guidelines for XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity0 embryonic stem cells (hESCs) exhibiting skewed X chromosome inactivation (XCI) have been reported. The copy number variations (CNVs), loss of heterozygosity (LOH), or single- @entity2 variant (SNV) events in those epigenetically distinct cells remain unknown, and whether such genetic abnormalities will influence the XCI status of hESCs is unclear. In this study, three hESCs with skewed XCI, three with random XCI, and two male hESC lines at different passages were analyzed for CNVs and LOH levels using a high-resolution genotyping microarray. Whole-exome sequencing was used to investigate the potentially damaging SNVs. On average, 17.6 CNVs and 5.3 cases of LOH were identified in the skewed hESCs, which were similar to the rates observed in random hESCs. Five recurrent @entity1 regions were uniquely identified in the skewed hESCs, but all of them were considered polymorphisms. With the exception of a nongenic @entity1 , no additional CNVs were detected on the X chromosome in the skewed hESCs. Although the XCI status in two hESC lines was observed to be changed from random to skewed, no significant @entity1 difference was identified before and after the XCI change. SNV analysis indicated that normal alleles are maintained for most genes within copy-neutral LOH regions. Three types of expression patterns were observed in heterozygous alleles, and the damaging SNVs in skewed hESCs favored the expression of the wild-type alleles. In conclusion, in the present study, we did not find genetic differences in the @entity1 and LOH levels between hESCs with and without skewed XCI. Wild-type allele expression in the presence of damaging SNVs on the X chromosome in skewed hESCs might alleviate adverse effects in those hESCs.

title: Genetic Evaluation of Copy Number Variations, Loss of Heterozygosity, and Single-Nucleotide Variant Levels in XXXX Embryonic Stem Cells With or Without Skewed X Chromosome Inactivation.

answer: @entity0


abstract: Central @entity6 have been reported on the hemiplegic side only. In a study on supratentorial @entity4 ( @entity4 ), we found @entity1 ( @entity1 ) prolongation on the non-hemiplegic side in 12 @entity0 . This study reports the prognostic significance of @entity1 prolongation on the non-hemiplegic side. CT scans were reviewed and @entity1 was measured at the 2nd, 4th and 12th week. Recovery was defined on the basis of the 3 months' Barthel index score. Their mean age was 52 (range 25-60) years, 6 were males. Eight had putaminal, 3 thalamic and 1 frontal hematomata. The size of the @entity3 was large in 5 and moderate in 7. The clinical signs of @entity5 were present in 5; radiological evidence of midline shift in 10 and tentorial @entity5 in 6 @entity0 was also present. There was no other @entity2 to account for the prolongation of @entity1 on the non-hemiplegic side which returned to normal in all 5 @entity0 after a mean duration of 34 (range 11-120) days. Five of these @entity0 died and the remaining had a poor outcome. We conclude that @entity1 prolongation on the non-hemiplegic side in supratentorial @entity3 suggests a poor prognosis.

title: Prognostic significance of central motor conduction on the non-hemiplegic side in supratentorial XXXX .

answer: @entity3


abstract: @entity2 is the most common form of @entity1 , and is caused by defects in the @entity3 gene. @entity3 is an RNA-binding protein and the syndrome results from lack of expression of @entity3 or expression of a mutant protein that is impaired in RNA binding. The specific function of @entity3 is not known. As a step towards understanding the function of @entity3 we searched for proteins that interact with it in vivo. We have cloned and sequenced a protein that interacts tightly with @entity3 in vivo and in vitro. This novel protein, @entity5 , is very similar to @entity3 (60% identity). @entity5 encodes a 74 kDa protein which, like @entity3 , contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The @entity5 gene is located on @entity0 chromosome 17 at 17p13.1. In addition, @entity3 and @entity5 interact tightly with the recently described autosomal homolog @entity4 . Each of these three proteins is capable of forming heteromers with the others, and each can also form homomers. @entity4 and @entity5 are thus likely to play important roles in the function of @entity3 and in the pathogenesis of the @entity2 .

title: The XXXX protein interacts with novel homologs @entity4 and @entity5 .

answer: @entity2


abstract: @entity2 is the most common form of @entity1 , and is caused by defects in the @entity3 gene. @entity3 is an RNA-binding protein and the syndrome results from lack of expression of @entity3 or expression of a mutant protein that is impaired in RNA binding. The specific function of @entity3 is not known. As a step towards understanding the function of @entity3 we searched for proteins that interact with it in vivo. We have cloned and sequenced a protein that interacts tightly with @entity3 in vivo and in vitro. This novel protein, @entity5 , is very similar to @entity3 (60% identity). @entity5 encodes a 74 kDa protein which, like @entity3 , contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The @entity5 gene is located on @entity0 chromosome 17 at 17p13.1. In addition, @entity3 and @entity5 interact tightly with the recently described autosomal homolog @entity4 . Each of these three proteins is capable of forming heteromers with the others, and each can also form homomers. @entity4 and @entity5 are thus likely to play important roles in the function of @entity3 and in the pathogenesis of the @entity2 .

title: The @entity2 protein interacts with novel homologs XXXX and @entity5 .

answer: @entity4


abstract: @entity2 is the most common form of @entity1 , and is caused by defects in the @entity3 gene. @entity3 is an RNA-binding protein and the syndrome results from lack of expression of @entity3 or expression of a mutant protein that is impaired in RNA binding. The specific function of @entity3 is not known. As a step towards understanding the function of @entity3 we searched for proteins that interact with it in vivo. We have cloned and sequenced a protein that interacts tightly with @entity3 in vivo and in vitro. This novel protein, @entity5 , is very similar to @entity3 (60% identity). @entity5 encodes a 74 kDa protein which, like @entity3 , contains two KH domains, has the capacity to bind RNA and is localized to the cytoplasm. The @entity5 gene is located on @entity0 chromosome 17 at 17p13.1. In addition, @entity3 and @entity5 interact tightly with the recently described autosomal homolog @entity4 . Each of these three proteins is capable of forming heteromers with the others, and each can also form homomers. @entity4 and @entity5 are thus likely to play important roles in the function of @entity3 and in the pathogenesis of the @entity2 .

title: The @entity2 protein interacts with novel homologs @entity4 and XXXX .

answer: @entity5


abstract: The aim of this study was to determine the relationship between @entity1 consumption and occurrence of @entity2 in the general population. During 1988 in a cross sectional survey, the Edinburgh Artery Study, 1,592 @entity0 and @entity0 aged 55-74 years were selected at random from the age-sex registers of ten general practices distributed geographically and socio-economically across the city. @entity0 were asked to recall the number of units of wine, beer and spirits consumed in the previous week and whether or not this was typical. @entity2 was measured using the ankle brachial pressure index (ABPI). @entity0 and @entity0 were analysed separately because of large differences in @entity1 consumption. There was no association between ABPI and @entity1 consumption in @entity0 but, in @entity0 , increasing @entity1 consumption was associated with a higher ABPI (test for trend, p = 0.03) indicating less severe disease. This relationship was linear rather than U-shaped. In multiple regression analysis, after age-adjustment the ABPI was related to wine consumption but not beer or spirits in @entity0 (p < or = 0.01). On adjusting for age and cumulative lifetime cigarette smoking, the association of wine consumption with the ABPI was diminished but remained statistically significant (p < 0.05). On adjusting for age and social class, the relationship of total @entity1 intake and wine consumption with the ABPI became non significant (p > 0.05). We conclude that in males, greater @entity1 consumption is related to a higher ABPI and that any protective 'effect' of @entity1 relates to wine consumption rather than beer or spirits.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX intake as a risk factor for @entity2 in the general population in the Edinburgh Artery Study.

answer: @entity1


abstract: The aim of this study was to determine the relationship between @entity1 consumption and occurrence of @entity2 in the general population. During 1988 in a cross sectional survey, the Edinburgh Artery Study, 1,592 @entity0 and @entity0 aged 55-74 years were selected at random from the age-sex registers of ten general practices distributed geographically and socio-economically across the city. @entity0 were asked to recall the number of units of wine, beer and spirits consumed in the previous week and whether or not this was typical. @entity2 was measured using the ankle brachial pressure index (ABPI). @entity0 and @entity0 were analysed separately because of large differences in @entity1 consumption. There was no association between ABPI and @entity1 consumption in @entity0 but, in @entity0 , increasing @entity1 consumption was associated with a higher ABPI (test for trend, p = 0.03) indicating less severe disease. This relationship was linear rather than U-shaped. In multiple regression analysis, after age-adjustment the ABPI was related to wine consumption but not beer or spirits in @entity0 (p < or = 0.01). On adjusting for age and cumulative lifetime cigarette smoking, the association of wine consumption with the ABPI was diminished but remained statistically significant (p < 0.05). On adjusting for age and social class, the relationship of total @entity1 intake and wine consumption with the ABPI became non significant (p > 0.05). We conclude that in males, greater @entity1 consumption is related to a higher ABPI and that any protective 'effect' of @entity1 relates to wine consumption rather than beer or spirits.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity1 intake as a risk factor for XXXX in the general population in the Edinburgh Artery Study.

answer: @entity2


abstract: Fat @entity3 (FES) is a serious clinical disorder occurring in @entity1 @entity0 . The diagnosis of @entity5 may be difficult to establish clinically. We therefore wanted to investigate the usefulness of bronchoalveolar lavage (BAL) in the diagnostic evaluation of @entity5 . We analysed the presence of fat droplets in BAL cells in 32 @entity1 @entity0 (7 with full diagnostic criteria of @entity5 , 17 with incomplete diagnostic criteria, and 8 with no diagnostic criteria at the time of bronchoscopy), 9 nontrauma @entity0 with @entity4 and @entity2 , and a control group composed of 10 individuals. An increased percentage of oil red O positive alveolar macrophages (cut-off point > 3%) in BAL was found in 6 out of 7 @entity0 with definite clinical criteria of @entity5 , and in 6 out of 20 @entity1 @entity0 without the clinical diagnosis of @entity5 . In two @entity0 with @entity5 , sequential BAL showed that the percentage of positive macrophages decreased when the clinical @entity6 disappeared. An increased number of BAL macrophages with fat droplets was also observed in two @entity1 @entity0 without evidence of @entity5 after long-bone surgical intervention. By contrast, all non- @entity1 @entity0 had a percentage of positive cells lower than 3%. Our findings suggest that BAL oil red O positive macrophages are frequently observed in @entity1 @entity0 irrespective of the presence of @entity5 . Conceivably, a high number of oil red O positive macrophages could reflect clinically silent fat embolization.

title: Role of bronchoalveolar lavage in the diagnosis of XXXX .

answer: @entity5


abstract: INTRODUCTION: @entity0 ( @entity0 ) has the highest mortality rates of all subtypes. @entity6 and @entity5 regimens yield unsatisfactorily low rates of pathologic complete response (pCR) and are often not feasible in cardiac comorbidity. This study seeks to increase pCR and survival by introducing platin agents. @entity1 AND METHODS: In this multicentric, open-label study with six cycles of @entity3 (75mg/m(2)) and @entity4 AUC 6 q3w, @entity1 were unwilling or unsuitable for @entity6 -based regimens. Primary endpoint was pCR (ypT0/ypTis ypN0) and survival. RESULTS: pCR rate was 50%. After 2 and 5years, overall survival (OS) was 96.7 and 89.7%, disease-free-survival (DFS) 96.7 and 85.7%, DDFS 96.7 and 89.6%. Grade 3/4 @entity2 were rare. Ninety-three per cent of @entity1 completed six cycles. No @entity2 -related treatment discontinuation or febrile neutropaenia was recorded. CONCLUSION: This regimen is highly effective and feasible in @entity0 and may be combined with @entity7 .

title: Neoadjuvant, XXXX -free chemotherapy with @entity4 and @entity3 in triple-negative, @entity0 : a multicentric analysis of rates of pathologic complete response and survival.

answer: @entity6


abstract: INTRODUCTION: @entity0 ( @entity0 ) has the highest mortality rates of all subtypes. @entity6 and @entity5 regimens yield unsatisfactorily low rates of pathologic complete response (pCR) and are often not feasible in cardiac comorbidity. This study seeks to increase pCR and survival by introducing platin agents. @entity1 AND METHODS: In this multicentric, open-label study with six cycles of @entity3 (75mg/m(2)) and @entity4 AUC 6 q3w, @entity1 were unwilling or unsuitable for @entity6 -based regimens. Primary endpoint was pCR (ypT0/ypTis ypN0) and survival. RESULTS: pCR rate was 50%. After 2 and 5years, overall survival (OS) was 96.7 and 89.7%, disease-free-survival (DFS) 96.7 and 85.7%, DDFS 96.7 and 89.6%. Grade 3/4 @entity2 were rare. Ninety-three per cent of @entity1 completed six cycles. No @entity2 -related treatment discontinuation or febrile neutropaenia was recorded. CONCLUSION: This regimen is highly effective and feasible in @entity0 and may be combined with @entity7 .

title: Neoadjuvant, @entity6 -free chemotherapy with @entity4 and @entity3 in triple-negative, XXXX : a multicentric analysis of rates of pathologic complete response and survival.

answer: @entity0


abstract: INTRODUCTION: @entity0 ( @entity0 ) has the highest mortality rates of all subtypes. @entity6 and @entity5 regimens yield unsatisfactorily low rates of pathologic complete response (pCR) and are often not feasible in cardiac comorbidity. This study seeks to increase pCR and survival by introducing platin agents. @entity1 AND METHODS: In this multicentric, open-label study with six cycles of @entity3 (75mg/m(2)) and @entity4 AUC 6 q3w, @entity1 were unwilling or unsuitable for @entity6 -based regimens. Primary endpoint was pCR (ypT0/ypTis ypN0) and survival. RESULTS: pCR rate was 50%. After 2 and 5years, overall survival (OS) was 96.7 and 89.7%, disease-free-survival (DFS) 96.7 and 85.7%, DDFS 96.7 and 89.6%. Grade 3/4 @entity2 were rare. Ninety-three per cent of @entity1 completed six cycles. No @entity2 -related treatment discontinuation or febrile neutropaenia was recorded. CONCLUSION: This regimen is highly effective and feasible in @entity0 and may be combined with @entity7 .

title: Neoadjuvant, @entity6 -free chemotherapy with XXXX and @entity3 in triple-negative, @entity0 : a multicentric analysis of rates of pathologic complete response and survival.

answer: @entity4


abstract: INTRODUCTION: @entity0 ( @entity0 ) has the highest mortality rates of all subtypes. @entity6 and @entity5 regimens yield unsatisfactorily low rates of pathologic complete response (pCR) and are often not feasible in cardiac comorbidity. This study seeks to increase pCR and survival by introducing platin agents. @entity1 AND METHODS: In this multicentric, open-label study with six cycles of @entity3 (75mg/m(2)) and @entity4 AUC 6 q3w, @entity1 were unwilling or unsuitable for @entity6 -based regimens. Primary endpoint was pCR (ypT0/ypTis ypN0) and survival. RESULTS: pCR rate was 50%. After 2 and 5years, overall survival (OS) was 96.7 and 89.7%, disease-free-survival (DFS) 96.7 and 85.7%, DDFS 96.7 and 89.6%. Grade 3/4 @entity2 were rare. Ninety-three per cent of @entity1 completed six cycles. No @entity2 -related treatment discontinuation or febrile neutropaenia was recorded. CONCLUSION: This regimen is highly effective and feasible in @entity0 and may be combined with @entity7 .

title: Neoadjuvant, @entity6 -free chemotherapy with @entity4 and XXXX in triple-negative, @entity0 : a multicentric analysis of rates of pathologic complete response and survival.

answer: @entity3


abstract: UNASSIGNED: Glandular lesions of the urinary bladder include a broad spectrum of entities ranging from completely benign to primary and secondary @entity0 . The accurate diagnosis of these lesions is both important and challenging. Recently, studies suggest that @entity7 ( @entity7 ) promoter mutations could be a biomarker for @entity2 ( @entity2 ). We hypothesized that these mutations can distinguish @entity2 with glandular differentiation from @entity4 , primary @entity6 (PAUB), or secondary @entity0 . Twenty-five cases of @entity1 (including @entity4 ); 29 cases of @entity2 with glandular differentiation; 10 cases of PAUB; and 10 cases each of metastatic @entity5 , @entity3 , and @entity2 from Mullerian origin were collected. Slides were reviewed and selected to make sure the lesion was at least 10% to 20% of all tissue. Macrodissection was performed in some of cases, and genomic DNA was extracted from the tissue. @entity7 promoter mutations were determined by standard polymerase chain reaction sequencing. Twenty-one cases (72%) of @entity2 with glandular differentiation were positive for @entity7 promoter mutations. However, none of the remaining cases (total 65 cases of benign lesions, PAUB, and @entity2 ) was positive for @entity7 promoter mutation. @entity7 promoter mutations were highly associated with @entity2 including @entity2 with glandular differentiation but not other glandular lesions of bladder. Therefore, in conjunction with morphologic features, Immunohistochemistry stain profile, and clinical information, @entity7 promoter mutations could distinguish @entity2 with glandular differentiation from other @entity6 . In addition, lack of @entity7 promoter mutations in primary @entity6 suggests that this entity may have different origin or carcinogenesis from those of @entity2 .

title: XXXX promoter mutations in glandular lesions of the urinary bladder.

answer: @entity7


abstract: UNASSIGNED: Food @entity1 prevalence has increased during the last years, affecting 15-20% of @entity0 , in this case, egg @entity1 affects from 0.5-2.5%. Most of the egg allergic reactions are type I or IgE mediated antibodies against egg proteins. Five major proteins have been identified: ovomucoid (Gal d1), ovoalbumin (Gal d2), ovotransferrin (Gal d3), lysozyme ( @entity2 ). Ovomucoid protein, which is found in the egg white, is heat resistant and enzyme resistant. This protein is the most allergenic and the most common in egg composition. Clinical diagnosis requires a detailed questionnaire. Skin prick test or Ige specific diagnosis are made as first choice. Skin prick tests are quick and useful to determine the presence of IgE specific antibodies to egg. Specific IgE for egg can be measured using standarized IgE studies in vitro, making a quantitative measure. Traditionally with the clinical history a diagnosis can be made. Standarized oral double blinded-placebo controlled challenge continues to be the gold standard for food @entity1 diagnosis. The identification and elimination of egg proteins from the diet is the primary treatment and the only one validated to this food, but there are more studies needed to stablish protocols for each specific egg allergen before the oral inmunotherapy becomes a routine practice.

title: [Allergy to egg proteins in XXXX ].

answer: @entity0


abstract: BACKGROUND: @entity4 are a group of prevalent and life-threatening diseases. Selective inhibition of pathological @entity4 holds the key to treat variety of @entity4 . The pathological @entity4 can be induced by either tissue @entity1 and deregulated @entity0 . @entity2 , as an important proinflammatory cytokine and a late mediator, also involves on @entity4 disease. However, the underlying mechanisms are not fully understood. METHODS: Immunofluorescence, ELISA assay, Platelet Aggregation, Thromboelastogram (TEG) analyzes. Flow cytometric analysis and Western blot analysis were used to investigated the role of @entity2 in @entity5 and obtained following observations. RESULTS: By doing so, we obtained the following observations: i) Highly purified @entity2 recombinant protein induces @entity5 and secretion in a dose-dependent manner in the presence of serum. ii) Low concentration of extracellular @entity2 could synergistically promote subthreshold concentration of collagen or @entity3 induced @entity5 . iii) Extracellular @entity2 promoted @entity5 in a platelet-expressed @entity6 /IIIa-dependent manner. iv) We proposed that extracellular @entity2 seems to promote the phosphorylation of @entity6 /IIIa and subsequent @entity5 via @entity7 /NF-kB and @entity8 pathway. CONCLUSIONS: In this study, we provide evidence for the hypothesis that @entity2 interact with platelet might play an important role in the haemostasis and @entity4 . Our research might be provide an interesting avenue for the treatment of @entity4 in the future.

title: @entity2 : a novel protein that induced platelets active and aggregation via @entity7 , NF-kB and XXXX dependent mechanisms.

answer: @entity8


abstract: BACKGROUND: @entity4 are a group of prevalent and life-threatening diseases. Selective inhibition of pathological @entity4 holds the key to treat variety of @entity4 . The pathological @entity4 can be induced by either tissue @entity1 and deregulated @entity0 . @entity2 , as an important proinflammatory cytokine and a late mediator, also involves on @entity4 disease. However, the underlying mechanisms are not fully understood. METHODS: Immunofluorescence, ELISA assay, Platelet Aggregation, Thromboelastogram (TEG) analyzes. Flow cytometric analysis and Western blot analysis were used to investigated the role of @entity2 in @entity5 and obtained following observations. RESULTS: By doing so, we obtained the following observations: i) Highly purified @entity2 recombinant protein induces @entity5 and secretion in a dose-dependent manner in the presence of serum. ii) Low concentration of extracellular @entity2 could synergistically promote subthreshold concentration of collagen or @entity3 induced @entity5 . iii) Extracellular @entity2 promoted @entity5 in a platelet-expressed @entity6 /IIIa-dependent manner. iv) We proposed that extracellular @entity2 seems to promote the phosphorylation of @entity6 /IIIa and subsequent @entity5 via @entity7 /NF-kB and @entity8 pathway. CONCLUSIONS: In this study, we provide evidence for the hypothesis that @entity2 interact with platelet might play an important role in the haemostasis and @entity4 . Our research might be provide an interesting avenue for the treatment of @entity4 in the future.

title: @entity2 : a novel protein that induced platelets active and aggregation via XXXX , NF-kB and @entity8 dependent mechanisms.

answer: @entity7


abstract: BACKGROUND: @entity4 are a group of prevalent and life-threatening diseases. Selective inhibition of pathological @entity4 holds the key to treat variety of @entity4 . The pathological @entity4 can be induced by either tissue @entity1 and deregulated @entity0 . @entity2 , as an important proinflammatory cytokine and a late mediator, also involves on @entity4 disease. However, the underlying mechanisms are not fully understood. METHODS: Immunofluorescence, ELISA assay, Platelet Aggregation, Thromboelastogram (TEG) analyzes. Flow cytometric analysis and Western blot analysis were used to investigated the role of @entity2 in @entity5 and obtained following observations. RESULTS: By doing so, we obtained the following observations: i) Highly purified @entity2 recombinant protein induces @entity5 and secretion in a dose-dependent manner in the presence of serum. ii) Low concentration of extracellular @entity2 could synergistically promote subthreshold concentration of collagen or @entity3 induced @entity5 . iii) Extracellular @entity2 promoted @entity5 in a platelet-expressed @entity6 /IIIa-dependent manner. iv) We proposed that extracellular @entity2 seems to promote the phosphorylation of @entity6 /IIIa and subsequent @entity5 via @entity7 /NF-kB and @entity8 pathway. CONCLUSIONS: In this study, we provide evidence for the hypothesis that @entity2 interact with platelet might play an important role in the haemostasis and @entity4 . Our research might be provide an interesting avenue for the treatment of @entity4 in the future.

title: XXXX : a novel protein that induced platelets active and aggregation via @entity7 , NF-kB and @entity8 dependent mechanisms.

answer: @entity2


abstract: The morphological consequences of @entity5 @entity3 are well documented. Much less is known about changes in visual function during degeneration and whether central @entity2 directly reflect changes in retinal ganglion cell (RGC) function. To address this, we compared changes in visual function of RGCs and cells in the superior colliculus (SC) in transgenic (Tg) @entity10 -1 @entity0 , a model of @entity6 ( @entity6 ), and @entity1 ( @entity1 ) @entity0 at postnatal days 35-50 (P35-50) and P300. RGCs were classified on the basis of their responses to light: onset (ON), offset (OFF), or both (ON-OFF). The distribution of ON, OFF, and ON-OFF RGCs is similar between @entity1 and P35 Tg @entity10 -1 @entity0 . By P300, many Tg @entity10 -1 RGCs are nonresponsive (NR). At this age, there is a sharp decline in ON and ON-OFF RGCs, and the majority that remain are OFF RGCs. Spontaneous rhythmic activity was observed in many RGCs at P300, but only in OFF or NR RGCs. In the SC, @entity1 and P50 Tg @entity10 -1 responses are similar. At P300, Tg @entity10 -1 ON SC responses declined but OFF responses increased. We examined postsynaptic @entity4 receptor expression located on the bipolar cells (BC), where the ON and OFF pathways arise. At @entity9 , metabotropic @entity4 receptor 6 ( @entity7 ) expression is lower than in @entity1 , consistent with a decrease in ON RGC responses. @entity8 expression, an ionotropic @entity4 receptor associated with OFF BCs, appears similar to that in @entity1 . The loss of ON responses in Tg @entity10 -1 RGCs and in the SC is conserved and related to reduced @entity7 signaling.

title: Functional changes in Tg XXXX -1 @entity0 retinal responses: differences between ON and OFF pathway transmission to the superior colliculus.

answer: @entity10


abstract: The morphological consequences of @entity5 @entity3 are well documented. Much less is known about changes in visual function during degeneration and whether central @entity2 directly reflect changes in retinal ganglion cell (RGC) function. To address this, we compared changes in visual function of RGCs and cells in the superior colliculus (SC) in transgenic (Tg) @entity10 -1 @entity0 , a model of @entity6 ( @entity6 ), and @entity1 ( @entity1 ) @entity0 at postnatal days 35-50 (P35-50) and P300. RGCs were classified on the basis of their responses to light: onset (ON), offset (OFF), or both (ON-OFF). The distribution of ON, OFF, and ON-OFF RGCs is similar between @entity1 and P35 Tg @entity10 -1 @entity0 . By P300, many Tg @entity10 -1 RGCs are nonresponsive (NR). At this age, there is a sharp decline in ON and ON-OFF RGCs, and the majority that remain are OFF RGCs. Spontaneous rhythmic activity was observed in many RGCs at P300, but only in OFF or NR RGCs. In the SC, @entity1 and P50 Tg @entity10 -1 responses are similar. At P300, Tg @entity10 -1 ON SC responses declined but OFF responses increased. We examined postsynaptic @entity4 receptor expression located on the bipolar cells (BC), where the ON and OFF pathways arise. At @entity9 , metabotropic @entity4 receptor 6 ( @entity7 ) expression is lower than in @entity1 , consistent with a decrease in ON RGC responses. @entity8 expression, an ionotropic @entity4 receptor associated with OFF BCs, appears similar to that in @entity1 . The loss of ON responses in Tg @entity10 -1 RGCs and in the SC is conserved and related to reduced @entity7 signaling.

title: Functional changes in Tg @entity10 -1 XXXX retinal responses: differences between ON and OFF pathway transmission to the superior colliculus.

answer: @entity0


abstract: AIM: The present study aimed: (1) to evaluate the proportion of each @entity1 ( @entity1 ) risk category, according to the International Working Group on the @entity1 (IWGDF) consensus, in @entity0 attending the @entity1 clinic in Selebi Phikwe Government Hospital (SPGH) and (2) to examine some of the factors that may be associated with the progression to higher risk categories such as anthropometric measurements, blood pressure, glycosylated haemoglobin (HbA1c) and lipid profile. METHODS: A retrospective, cross sectional chart review of @entity0 who had attended the @entity1 clinic in SPGH from January 2013 to December 2013  was performed. @entity0 were included if they had undergone  a foot examination. @entity0 with amputation due to accident were excluded. The @entity1 risk category was assessed by determining the proportion of @entity0 in each of four risk categories,  as described  by the IWGDF consensus. RESULTS: The study encompassed 144 records from @entity0 reviewed for foot examination from January to December 2013. @entity0 ' ages were between 16 and 85 years, 46 (40%) were male and 98 (60%) were female. The majority (122, [85%]) of @entity0 were in @entity1 risk category 0, whilst a limited number of @entity0 were classified in risk category 1 (10, [6.9%]), risk category 2 (7, [4.9%]) and risk category 3 (5, [3.5%]). Most of the @entity0 had the @entity1 (139, [97%; 95% CI 92% - 99%]). @entity0 ' ages were associated with the progressively higher @entity1 risk categories. The adjusted odd ratio was 1.1 (95% CI 1.03-1.14;  p = 0.004). CONCLUSION: The present study revealed that about 15% of @entity0 attending the SPGH @entity1 clinic were categorised in higher risk groups for @entity1 ; @entity0 ' ages were linked to the higher @entity1 risk categories.

title: The XXXX risks profile in Selebi Phikwe Government Hospital, Botswana.

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity3 ) in @entity0 with @entity5 ( @entity5 ) is still controversial. The aim of this study was to examine the risk factors and the incidence of central lymph node metastases (CLNMs) in @entity0 with @entity5 who underwent thyroidectomy and @entity3 . @entity0 AND METHODS: Between 2002 and 2013, 613 @entity0 were enrolled who underwent thyroidectomy with routine @entity3 for @entity5 at the Korea University Medical Center, Ansan Hospital and risk factors and the incidence of CLNM were analyzed. In addition, we also evaluated the complications after thyroidectomy with @entity3 . RESULTS: Out of 613 @entity0 , 239 (39.0%) were found to have CLNM. Male sex (p  =  0.012), @entity1 size >=  0.5  cm (p  =  0.001), capsular invasion or extrathyroidal extension (p  =  0.029), and multifocality (p  =  0.004) were independent risk factors for CLNM. Among the 69 @entity0 who had @entity5 without these risk factors, CLNM was identified in 12 (17.4%). In this study group, two (0.3%) had permanent recurrent @entity6 , two (0.3%) had persistent @entity4 , and two (0.3%) developed @entity2 . CONCLUSION: CLNM in @entity5 is highly prevalent in male sex, @entity1 size >=  0.5  cm, extrathyroidal extension, and multifocality. Even in @entity5 @entity0 without these risk factors, the incidence of CLNM is rather higher than expected, and the complication rate of thyroidectomy with @entity3 is acceptable. Thus, @entity3 should be considered in all @entity0 with @entity5 .

title: Should central lymph node dissection be considered for all XXXX ?

answer: @entity5


abstract: UNASSIGNED: We perform a systematic review of repeat radiosurgery for @entity3 ( @entity2 ) with an emphasis on lesion obliteration rates and complications. Radiosurgery is an accepted treatment modality for @entity2 located in eloquent cortex or deep brain structures. For residual or persistent lesions, repeat radiosurgery can be considered if sufficient time has passed to allow for a full appreciation of treatment effects, usually at least 3years. A systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. References for this review were identified by searches of MEDLINE, Web of Science and Google Scholar databases. A total of 14 studies comprising 733 @entity0 met the review criteria and were included. For series that reported target dose at both first and repeat treatments, the weighted means were 19.42Gy and 19.06Gy, respectively. The mean and median obliteration rate for the repeat radiosurgery treatments were 61% (95% confidence interval 51.9-71.7%) and 61.5%, respectively. The median follow up following radiosurgery ranged from 19.5 to 80months. Time to complete obliteration after the repeat treatment ranged from 21 to 40.8months. The most common complications of repeat radiosurgery for @entity2 included @entity1 (7.6%) and radiation-induced changes (7.4%). Repeat radiosurgery can be used to treat incompletely obliterated @entity2 with an obliteration rate of 61%. Complications are related to treatment effect latency ( @entity1 risk) as well as radiation-induced changes. Repeat radiosurgery can be performed at 3 years following the initial treatment, allowing for full realization of effects from the initial treatment prior to commencing therapy.

title: Repeat radiosurgery for XXXX .

answer: @entity3


abstract: OBJECTIVE: To determine the prevalence of @entity4 in a nursing home population and to identify clinical factors that increase the risk for development of @entity4 . DESIGN: Retrospective and prospective record review. SETTING: A Veterans Affairs nursing home care unit. @entity0 : One hundred nineteen residents, who ranged in age from 60 to 103 years. Sixty ambulatory @entity0 , 62 to 91 years of age, who attended a geriatric medicine outpatient clinic served as a reference population. MEASUREMENTS: Most recent serum @entity3 , @entity2 , BUN, and all serum @entity3 determinations during the preceding 12 months; clinical diagnoses, diet, medications, and significant events at the time of recorded hyponatremic episodes; response to acute water loading in a subset of @entity0 ; number of deaths in the 12 months following entry into the study. RESULTS: In the 119 nursing home @entity0 , ages 60 years or older, the most recent serum @entity3 identified 18% who were hyponatremic, compared with a prevalence of 8% in similarly aged ambulatory @entity0 . When all serum @entity3 determinations for the previous 12 months were examined, 53% of the nursing home @entity0 had at least one episode of @entity4 during this time period. There was a high incidence of central nervous system (CNS) and @entity1 in the total nursing home population. Episodes of @entity4 were frequently associated with an increased intake of fluids, given either orally or intravenously, and with tube feeding. Water load testing revealed abnormal water handling consistent with the syndrome of inappropriate @entity5 ( @entity5 ) secretion in 18 of 23 @entity0 who had a history of @entity4 . Seventeen percent of the @entity0 with @entity4 died over the following 12 months, compared to a death rate of 21% in the normonatremic @entity0 . CONCLUSIONS: @entity4 is a common occurrence in nursing home residents and may be a consequence of abnormal @entity5 secretion resulting from @entity6 . Exposure to increased fluid intake, or to a low @entity3 tube-feeding diet, can lead to the onset of @entity4 or to a worsening of an already present low-serum @entity3 concentration.

title: XXXX in a nursing home population.

answer: @entity4


abstract: UNASSIGNED: Generation of DNA fragments is a hallmark of cell apoptosis and is executed within the dying cells (autonomous) or in the engulfing cells (non-autonomous). The TUNEL method is used as an in situ assay of apoptosis by labeling DNA fragments generated by caspase associated DNase (CAD), but not those by the downstream DNase II. Here, we report a method of ToLFP (topoisomerase ligation fluorescence probes) for directly visualizing DNA fragments generated by DNase II in @entity0 embryos. ToLFP analysis provided the first demonstration of a cell autonomous mode of DNase II activity in dying cells in @entity1 embryos, which are defective in engulfing apoptotic bodies. Compared with the number of ToLFP signals between @entity1 and wild-type (N2) embryos, a 30% increase in N2 embryos was found, suggesting that the ratio of non-autonomous and autonomous modes of DNase II was about 3 to 7. Among three DNase II mutant embryos ( @entity2 , @entity3 , and @entity4 ), @entity2 embryos exhibited the least number of ToLFP. The ToLFP results confirmed the previous findings that @entity2 is the major DNase II for degrading apoptotic DNA. To further elucidate @entity2 's mode of action, @entity2 -rescuing transgenic worms that ectopically express free or membrane-bound forms of @entity2 fusion proteins were utilized. ToLFP analyses revealed that anteriorly expressed @entity2 digests apoptotic DNA in posterior blastomeres in a non-autonomous and secretion-dependent manner. Collectively, we demonstrate that the ToLFP method can be used to differentiate the locations of blastomeres where DNase II acts autonomously or non-autonomously in degrading apoptotic DNA.

title: Autonomous and non-autonomous roles of DNase II during cell death in XXXX embryos.

answer: @entity0


abstract: BACKGROUND: An increase in interstitial bony fluid occurs in bone- @entity6 (BME). The exact pathogenetic processes still remain unknown. BME is an unspecific finding that can occur on its own or accompany @entity2 and pathologies. GOAL: Literature review and presentation of new guidelines. MATERIAL AND METHODS: This is a narrative literature review followed by current advice for the therapy of atraumatic @entity8 of the hip, based on the recently published S3-guidelines for this disease. RESULTS AND DISCUSSION: The differentiation of at least 3 different etiologies is proposed (mechanic, reactive and @entity1 ). Difficult, but important, is the distinction between the mostly painful, but benign entities ( @entity6 , @entity3 ) and the progressive pathologies ( @entity8 , @entity7 , @entity9 , @entity0 ). Treatment options are dependent on etiology and clinic and can often be symptomatic. Core decompression is the surgical gold standard, leading to immediate pressure relief and therefore reduction in @entity4 . Recently, it was shown that intravenous administration of Iloprost and @entity5 are also effective in achieving a reduction of BME and @entity4 , with considerable improvement in the accompanying symptoms. The combination of core decompression and infusion seems to be another possible optimization ofthe therapy, in particular in the treatment of @entity8 .

title: [Bone XXXX and atraumatic necrosis of the femoral head : Therapy].

answer: @entity6


abstract: BACKGROUND: Despite improved operative techniques, open @entity3 repair (VHR) surgery in high-risk, potentially contaminated @entity0 remains challenging. As previously reported by our group, the use of a modified negative-pressure wound therapy system (hybrid-VAC or HVAC) in @entity0 with grade 2 @entity2 is associated with lower surgical site occurrence (SSO) and @entity1 ( @entity1 ) rates. Accordingly, the authors aim to evaluate whether the HVAC would similarly improve surgical site outcomes following VHR in @entity0 with grade 3 @entity2 . METHODS: A 4-year retrospective review (2011-2014) was conducted of all consecutive, modified @entity3 working group (VHWG) grade 3 @entity2 repairs with HVAC closure performed by a single surgeon (FEE) at a single institution. Operative data and 90-day outcomes were evaluated. Overall outcomes (e.g., recurrence, reoperation, mortality) were reviewed for the study group. RESULTS: A total of 117 @entity0 with an average age of 56.7        11.9  years were classified as grade 3 @entity2 and underwent open VHR with subsequent HVAC closure. Fifty @entity0 were male (42.7  %), the mean BMI was 35.2 (  9.5), and 60.7  % had a history of prior @entity2 repair. The average fascial defect size was 201.5 (  167.3)   cm(2) and the mean length of stay was 14.2 (  9.3)   days. Ninety-day outcomes showed an SSO rate of 20.7  % and an  @entity1 rate of  5.2  %. The overall @entity2 recurrence rate was 4.2 % (n=6) with a mean follow-up of 11        7.3  months. CONCLUSION: Modified VHWG grade 3 @entity3 are associated with significant morbidity. In our series utilizing the HVAC system after VHR, the observed rate of SSO and @entity1 compared favorably to reported series. Further prospective cost-effective studies are warranted to validate these findings.

title: Negative-Pressure Wound Therapy in the Management of High-Grade XXXX .

answer: @entity3


abstract: UNASSIGNED: In the present study, induced pluripotent stem cells (iPSCs), induced neural stem cells (iNSCs), mesenchymal stem cells (MSCs) and an immortalized cell line (RMNE6), representing different characteristics of stem cells, were transplanted into normal and/or injured brain areas of @entity3 models, and their effects were compared to select suitable stem cells for cell replacement @entity3 therapy. The @entity2 and @entity1 ischaemic models were constructed using the middle cerebral artery occlusion technique. Both electrocoagulation of the artery and the intraluminal filament technique were used. The behaviour changes and fates of grafted stem cells were determined mainly by behaviour testing and immunocytochemistry. Following iPSC transplantation into the corpora striata of normal @entity1 , a @entity0 developed in the brain. The iNSCs survived well and migrated towards the injured area without differentiation. Although there was no tumourigenesis in the brain of normal or ischaemic @entity1 after the iNSCs were transplanted in the cortices, the behaviour in ischaemic @entity1 was not improved. Upon transplanting MSC and RMNE6 cells into ischaemic @entity2 brains, results similar to iNSCs in @entity1 were seen. However, transplantation of RMNE6 caused a @entity4 . Thus, tumourigenesis and indeterminate improvement of behaviour are challenging problems encountered in stem cell therapy for @entity3 , and the intrinsic characteristics of stem cells should be remodelled before transplantation. Copyright    2015 John Wiley _ Sons, Ltd.

title: Comparison of intracerebral transplantation effects of different stem cells on XXXX models.

answer: @entity3


abstract: OBJECTIVES: To examine the association between @entity6 , total and bioavailable @entity4 , @entity9 , and total and bioavailable @entity1 concentrations and the risk of @entity3 from cardiovascular and @entity5 . DESIGN: 19 year old population based prospective study with 99.9% follow up. SETTING: Rancho Bernardo, California. SUBJECTS: 651 postmenopausal @entity0 , none taking @entity7 . MAIN OUTCOME MEASURES: Concentrations of plasma sex hormones measured by radioimmunoassay in an endocrinology research laboratory. Cardiovascular and @entity5 deaths assessed by @entity3 certificate; 85% of 30% sample validated by record review. RESULTS: Age adjusted concentrations of sex hormones did not differ significantly in @entity0 with and without a history of @entity5 at baseline and did not predict @entity2 or @entity3 from @entity5 . Most 95% confidence intervals for the age adjusted relative risk of @entity2 or @entity3 from @entity5 were narrow, and all included one. Endogenous @entity7 concentrations were not associated with significantly more favourable risk factors for @entity5 , and @entity4 was not associated with less favourable risk factors. CONCLUSION: These prospective data do not support a causal or preventive role for endogenous @entity7 or @entity8 and cardiovascular mortality in older @entity0 .

title: Prospective study of endogenous sex hormones and fatal XXXX in postmenopausal @entity0 .

answer: @entity2


abstract: OBJECTIVES: To examine the association between @entity6 , total and bioavailable @entity4 , @entity9 , and total and bioavailable @entity1 concentrations and the risk of @entity3 from cardiovascular and @entity5 . DESIGN: 19 year old population based prospective study with 99.9% follow up. SETTING: Rancho Bernardo, California. SUBJECTS: 651 postmenopausal @entity0 , none taking @entity7 . MAIN OUTCOME MEASURES: Concentrations of plasma sex hormones measured by radioimmunoassay in an endocrinology research laboratory. Cardiovascular and @entity5 deaths assessed by @entity3 certificate; 85% of 30% sample validated by record review. RESULTS: Age adjusted concentrations of sex hormones did not differ significantly in @entity0 with and without a history of @entity5 at baseline and did not predict @entity2 or @entity3 from @entity5 . Most 95% confidence intervals for the age adjusted relative risk of @entity2 or @entity3 from @entity5 were narrow, and all included one. Endogenous @entity7 concentrations were not associated with significantly more favourable risk factors for @entity5 , and @entity4 was not associated with less favourable risk factors. CONCLUSION: These prospective data do not support a causal or preventive role for endogenous @entity7 or @entity8 and cardiovascular mortality in older @entity0 .

title: Prospective study of endogenous sex hormones and fatal @entity2 in postmenopausal XXXX .

answer: @entity0


abstract: AIM: To compare the outcomes of @entity3 (TACE) for @entity4 ( @entity4 ) according to the Barcelona Clinic @entity2 (BCLC) staging system. METHODS: A consecutive sample of 540 @entity0 with solitary @entity4 who underwent liver resection (n = 312) or TACE (n = 128) were included in the present study. Baseline characteristics, @entity1 characteristics, and post-operative complications were compared between the two groups. The Kaplan-Meier method was used for long-term survival analysis. Independent prognostic predictors were identified using the Cox proportional hazards model (univariate and multivariate analyses). RESULTS: The TACE and liver resection groups had similar baseline demographic and clinicopathological characteristics. The TACE group showed a significantly lower rate of major complications than the liver resection group (3.9% vs 17.4%, P < 0.001). Univariate and multivariate analyses indicated that TACE did not contribute to poor overall survival compared with liver resection; however, a solitary @entity1 diameter of greater than 6 cm should be considered a risk factor for poor overall survival (HR = 1.328, 95%CI: 1.002-1.783, P = 0.048). The liver resection and TACE groups had comparable overall survival rates at 1 year, 3 years, and 5 years (86.2%, 62.8%, and 44.0% vs 88.3%, 59.8%, and 40.6%, respectively, P = 0.419). In cases with @entity1 diameters equal to or less than 6 cm, the liver resection group showed a survival benefit compared with the TACE group at 1 year, 3 years, and 5 years (P = 0.030). The 1-, 3-, and 5-year overall survival rates of @entity4 cases with @entity1 diameters of more than 6 cm were similar among the liver resection and TACE groups (P = 0.467). CONCLUSION: A @entity1 diameter of 6 cm should be the cutoff for deciding between liver resection and TACE.

title: XXXX for @entity4 .

answer: @entity3


abstract: AIM: To compare the outcomes of @entity3 (TACE) for @entity4 ( @entity4 ) according to the Barcelona Clinic @entity2 (BCLC) staging system. METHODS: A consecutive sample of 540 @entity0 with solitary @entity4 who underwent liver resection (n = 312) or TACE (n = 128) were included in the present study. Baseline characteristics, @entity1 characteristics, and post-operative complications were compared between the two groups. The Kaplan-Meier method was used for long-term survival analysis. Independent prognostic predictors were identified using the Cox proportional hazards model (univariate and multivariate analyses). RESULTS: The TACE and liver resection groups had similar baseline demographic and clinicopathological characteristics. The TACE group showed a significantly lower rate of major complications than the liver resection group (3.9% vs 17.4%, P < 0.001). Univariate and multivariate analyses indicated that TACE did not contribute to poor overall survival compared with liver resection; however, a solitary @entity1 diameter of greater than 6 cm should be considered a risk factor for poor overall survival (HR = 1.328, 95%CI: 1.002-1.783, P = 0.048). The liver resection and TACE groups had comparable overall survival rates at 1 year, 3 years, and 5 years (86.2%, 62.8%, and 44.0% vs 88.3%, 59.8%, and 40.6%, respectively, P = 0.419). In cases with @entity1 diameters equal to or less than 6 cm, the liver resection group showed a survival benefit compared with the TACE group at 1 year, 3 years, and 5 years (P = 0.030). The 1-, 3-, and 5-year overall survival rates of @entity4 cases with @entity1 diameters of more than 6 cm were similar among the liver resection and TACE groups (P = 0.467). CONCLUSION: A @entity1 diameter of 6 cm should be the cutoff for deciding between liver resection and TACE.

title: @entity3 for XXXX .

answer: @entity4


abstract: @entity3 strains are being developed as microbial production hosts for production of a range of amphiphilic and hydrophobic biochemicals. @entity3 's obligate aerobic growth thereby can be an economical and technical challenge because it requires constant rigorous aeration and often causes reactor foaming. Here, we engineered a strain of @entity5 that can produce @entity6 redox-mediators from @entity1 to allow partial redox balancing with an electrode under @entity0 -limited conditions. @entity1 is known to employ its @entity6 -type redox mediators for electron exchange with an anode in bioelectrochemical systems (BES). We transferred the seven core @entity6 biosynthesis genes phzA-G and the two specific genes phzM and phzS required for @entity4 synthesis from @entity1 on two inducible plasmids into @entity5 . The best clone, @entity3 pPhz, produced 45 mg/L @entity4 over 25 h of growth, which was visible as blue color formation and is comparable to the @entity4 production of @entity1 . This new strain was then characterized under different @entity0 -limited conditions with electrochemical redox control and changes in central energy metabolism were evaluated in comparison to the unmodified @entity5 . In the new strain, @entity6 synthesis with supernatant concentrations up to 33  g/mL correlated linearly with the ability to discharge electrons to an anode, whereby @entity2 served as the dominating redox mediator. @entity3 pPhz sustained strongly @entity0 -limited metabolism for up to 2 weeks at up to 12  A/cm(2) anodic current density. Together, this work lays a foundation for future @entity0 -limited biocatalysis with @entity3 strains.

title: Engineering mediator-based electroactivity in the obligate aerobic bacterium XXXX .

answer: @entity5


abstract: BACKGROUND: Acute @entity7 is a rare, but potentially life-threatening, cause of upper @entity2 . CLINICAL CASE: Male of 60  years old with severe @entity1 and @entity5 with haematemesis on two occasions. The @entity0 was haemodynamically stable, with @entity5 and palpable @entity8 . Hematic cytology showed: haemoglobin 8.2g/dl and haematocrit 27%. Abdominal X-ray showed an elevation of left diaphragm with a hugely dilated @entity6 . A nasogastric tube was inserted. Endoscopy was performed. There was no active @entity4 , but it was impossible to reach the duodenum due to the @entity6 distortion. The upper gastrointestinal X-ray study showed the appearance of an inverted @entity6 in the chest and an organoaxial gastric torsion. The CT scans of thorax and abdomen showed a gastric ascent into the thoracic cavity. Laparoscopic surgery was performed, finding the left hemi-diaphragm elevated, and the @entity6 , splenic angle of the colon, the spleen and tail of the pancreas were also raised. A linear gastrectomy ( @entity3 ) was performed. The postoperative progress was satisfactory. Oral feeding was started 72hours after surgery, and the @entity0 was discharged, and has remained asymptomatic during the following by 8  years. CONCLUSIONS: Emergency physicians must maintain a high level of suspicion in @entity0 that present with signs and symptoms suggesting upper digestive tract occlusion. The @entity3 is an excellent alternative to avoid recurrence of @entity7 .

title: [Laparoscopic XXXX in @entity7 secondary to diaphragmatic eventration in an adult @entity0 ].

answer: @entity3


abstract: BACKGROUND: Acute @entity7 is a rare, but potentially life-threatening, cause of upper @entity2 . CLINICAL CASE: Male of 60  years old with severe @entity1 and @entity5 with haematemesis on two occasions. The @entity0 was haemodynamically stable, with @entity5 and palpable @entity8 . Hematic cytology showed: haemoglobin 8.2g/dl and haematocrit 27%. Abdominal X-ray showed an elevation of left diaphragm with a hugely dilated @entity6 . A nasogastric tube was inserted. Endoscopy was performed. There was no active @entity4 , but it was impossible to reach the duodenum due to the @entity6 distortion. The upper gastrointestinal X-ray study showed the appearance of an inverted @entity6 in the chest and an organoaxial gastric torsion. The CT scans of thorax and abdomen showed a gastric ascent into the thoracic cavity. Laparoscopic surgery was performed, finding the left hemi-diaphragm elevated, and the @entity6 , splenic angle of the colon, the spleen and tail of the pancreas were also raised. A linear gastrectomy ( @entity3 ) was performed. The postoperative progress was satisfactory. Oral feeding was started 72hours after surgery, and the @entity0 was discharged, and has remained asymptomatic during the following by 8  years. CONCLUSIONS: Emergency physicians must maintain a high level of suspicion in @entity0 that present with signs and symptoms suggesting upper digestive tract occlusion. The @entity3 is an excellent alternative to avoid recurrence of @entity7 .

title: [Laparoscopic @entity3 in XXXX secondary to diaphragmatic eventration in an adult @entity0 ].

answer: @entity7


abstract: BACKGROUND: Acute @entity7 is a rare, but potentially life-threatening, cause of upper @entity2 . CLINICAL CASE: Male of 60  years old with severe @entity1 and @entity5 with haematemesis on two occasions. The @entity0 was haemodynamically stable, with @entity5 and palpable @entity8 . Hematic cytology showed: haemoglobin 8.2g/dl and haematocrit 27%. Abdominal X-ray showed an elevation of left diaphragm with a hugely dilated @entity6 . A nasogastric tube was inserted. Endoscopy was performed. There was no active @entity4 , but it was impossible to reach the duodenum due to the @entity6 distortion. The upper gastrointestinal X-ray study showed the appearance of an inverted @entity6 in the chest and an organoaxial gastric torsion. The CT scans of thorax and abdomen showed a gastric ascent into the thoracic cavity. Laparoscopic surgery was performed, finding the left hemi-diaphragm elevated, and the @entity6 , splenic angle of the colon, the spleen and tail of the pancreas were also raised. A linear gastrectomy ( @entity3 ) was performed. The postoperative progress was satisfactory. Oral feeding was started 72hours after surgery, and the @entity0 was discharged, and has remained asymptomatic during the following by 8  years. CONCLUSIONS: Emergency physicians must maintain a high level of suspicion in @entity0 that present with signs and symptoms suggesting upper digestive tract occlusion. The @entity3 is an excellent alternative to avoid recurrence of @entity7 .

title: [Laparoscopic @entity3 in @entity7 secondary to diaphragmatic eventration in an adult XXXX ].

answer: @entity0


abstract: The upper digestive @entity3 is one of the main causes of mortality from @entity4 ( @entity1 ). The measurement of the @entity2 ( @entity2 ) by angiographic way can be used for the determination of the risk of @entity3 . The aim of this study is to verify the influence of the @entity2 measurement upon the survival in @entity0 with @entity1 and upper digestive @entity3 . A retrospective pilot study on 33 @entity0 with upper digestive @entity3 divided into two groups according to the therapeutic attitude followed, was carried out. One group was classically treated, with variceal band ligation, non-elective beta-blockers and in emergency Octreotide. The other group was treated depending on the value of @entity2 . From the moment of the first episode of digestive @entity3 , the survival period was in average of 8.1 months for the @entity0 with viral etiology and for those with alcoholic etiology it was of 19.7 months. In @entity0 treated after @entity2 measurement, the average survival period was of 34.2 months and in @entity0 "classically" treated, the average survival period was of 15.5 months (significant difference). In conclusion, the measurement of @entity2 allowed the selection of a high-risk group of @entity0 . This permitted the making of a therapeutical decision with a significant prolongation of life in these @entity0 .

title: Measuring the XXXX in the upper digestive hemorrhages.

answer: @entity2


abstract: AIM: To outline the feasibility, safety, adverse events and early results of endoscopic ultrasound (EUS)-radiofrequency ablation (RFA) in @entity6 using a novel probe. METHODS: This is a multi-center, pilot safety feasibility study. The intervention described was radiofrequency ablation (RF) which was applied with an innovative monopolar RF probe (1.2 mm Habib EUS-RFA catheter) placed through a 19 or 22 gauge fine needle aspiration (FNA) needle once FNA was performed in @entity0 with a @entity1 in the head of the pancreas. The Habib    EUS-RFA is a 1 Fr wire (0.33 mm, 0.013") with a working length of 190 cm, which can be inserted through the biopsy channel of an echoendoscope. RF power is applied to the electrode at the end of the wire to coagulate tissue in the liver and pancreas. RESULTS: Eight @entity0 [median age of 65 (range 27-82) years; 7 female and 1 male] were recruited in a prospective multicenter trial. Six had a @entity6 (four a @entity3 , one had @entity7 and one a @entity5 ) and two had a @entity1 ( @entity1 ) in the head of pancreas. The mean size of the @entity1 and @entity1 were 36.5 mm (SD    17.9 mm) and 27.5 mm (SD    17.7 mm) respectively. The EUS-RFA was successfully completed in all cases. Among the 6 @entity0 with a @entity1 , post procedure imaging in 3-6 mo showed complete resolution of the cysts in 2 cases, whilst in three more there was a 48.4% reduction [mean pre RF 38.8 mm (SD    21.7 mm) vs mean post RF 20 mm (SD    17.1 mm)] in size. In regards to the @entity1 @entity0 , there was a change in vascularity and central @entity2 after EUS-RFA. No major complications were observed within 48 h of the procedure. Two @entity0 had mild @entity4 that resolved within 3 d. CONCLUSION: EUS-RFA of @entity6 with a novel monopolar RF probe was well tolerated in all cases. Our preliminary data suggest that the procedure is straightforward and safe. The response ranged from complete resolution to a 50% reduction in size.

title: Endoscopic ultrasound guided radiofrequency ablation, for XXXX .

answer: @entity6


abstract: UNASSIGNED: The role of circulating @entity2 cells (CTCs) as a marker for disease progression in @entity2 is controversial. The current review will serve to summarize the evidence on CTCs as a marker of disease progression in @entity1 with metastatic @entity0 . The immunohistochemistry(IHC)-based CellSearch(  ) is the only FDA-approved isolation technique for quantifying CTCs in @entity1 with metastatic @entity0 . We searched PubMed and Web of Knowledge for clinical studies that assessed the prognostic and predictive value of CTCs using IHC-based isolation. The @entity1 outcomes reported include median and Cox-proportional hazard ratios for overall-survival (OS) and progression-free-survival (PFS). All studies reported shorter OS for CTC-positive @entity1 versus CTC-negative. A subset of the selected trials reported significant lower median PFS for CTC-positive @entity1 . The reported trials support the utility of CTC enumeration for @entity1 prognosis. But further studies are required to determine the utility of CTC enumeration for guiding @entity1 therapy. There are three clinical trials ongoing to test this hypothesis. These studies, and others, will further establish the role of CTCs in clinical practice.

title: Circulating @entity2 Cells in Metastatic XXXX : A Prognostic and Predictive Marker.

answer: @entity0


abstract: UNASSIGNED: The role of circulating @entity2 cells (CTCs) as a marker for disease progression in @entity2 is controversial. The current review will serve to summarize the evidence on CTCs as a marker of disease progression in @entity1 with metastatic @entity0 . The immunohistochemistry(IHC)-based CellSearch(  ) is the only FDA-approved isolation technique for quantifying CTCs in @entity1 with metastatic @entity0 . We searched PubMed and Web of Knowledge for clinical studies that assessed the prognostic and predictive value of CTCs using IHC-based isolation. The @entity1 outcomes reported include median and Cox-proportional hazard ratios for overall-survival (OS) and progression-free-survival (PFS). All studies reported shorter OS for CTC-positive @entity1 versus CTC-negative. A subset of the selected trials reported significant lower median PFS for CTC-positive @entity1 . The reported trials support the utility of CTC enumeration for @entity1 prognosis. But further studies are required to determine the utility of CTC enumeration for guiding @entity1 therapy. There are three clinical trials ongoing to test this hypothesis. These studies, and others, will further establish the role of CTCs in clinical practice.

title: Circulating XXXX Cells in Metastatic @entity0 : A Prognostic and Predictive Marker.

answer: @entity2


abstract: UNASSIGNED: Epithelial-mesenchymal transition (EMT) is associated with the @entity1 and poor prognosis of @entity2 . However, the underlying mechanisms are poorly defined. In the present study, we investigated whether Twist  plays a direct role in @entity0 @entity2 using immunohistochemical and western blot analyses. Immunohistochemical analysis revealed that Twist  is highly expressed in @entity2 , which correlates with poor @entity2 pathological differentiation or lymph node @entity1 (P<0.05). Depletion of Twist  by stable shRNA-mediated knockdown decreased the migratory ability of @entity2 cell lines in  vitro. Suppression or overexpression of Twist  also resulted in an altered expression of the molecular mediators of EMT. Furthermore, exogenous @entity3 promoted EMT by upregulating the expression of Twist  through the @entity3 / @entity4 pathway, and this effect was eliminated by Twist  depletion in @entity2 cells as demonstrated in the in  vitro study. The use of in  vivo models revealed a decreased @entity2 proliferation potential in Twist-depleted @entity2 cells. The results suggested a novel function for Twist  in the promotion of EMT via @entity3 / @entity4 signaling pathway. Thus, Twist  constitutes a potential therapeutic target in @entity0 @entity2 .

title: Twist  induces epithelial-mesenchymal transition in cervical carcinogenesis by regulating the @entity3 / XXXX signaling pathway.

answer: @entity4


abstract: UNASSIGNED: Epithelial-mesenchymal transition (EMT) is associated with the @entity1 and poor prognosis of @entity2 . However, the underlying mechanisms are poorly defined. In the present study, we investigated whether Twist  plays a direct role in @entity0 @entity2 using immunohistochemical and western blot analyses. Immunohistochemical analysis revealed that Twist  is highly expressed in @entity2 , which correlates with poor @entity2 pathological differentiation or lymph node @entity1 (P<0.05). Depletion of Twist  by stable shRNA-mediated knockdown decreased the migratory ability of @entity2 cell lines in  vitro. Suppression or overexpression of Twist  also resulted in an altered expression of the molecular mediators of EMT. Furthermore, exogenous @entity3 promoted EMT by upregulating the expression of Twist  through the @entity3 / @entity4 pathway, and this effect was eliminated by Twist  depletion in @entity2 cells as demonstrated in the in  vitro study. The use of in  vivo models revealed a decreased @entity2 proliferation potential in Twist-depleted @entity2 cells. The results suggested a novel function for Twist  in the promotion of EMT via @entity3 / @entity4 signaling pathway. Thus, Twist  constitutes a potential therapeutic target in @entity0 @entity2 .

title: Twist  induces epithelial-mesenchymal transition in cervical carcinogenesis by regulating the XXXX / @entity4 signaling pathway.

answer: @entity3


abstract: INTRODUCTION: @entity1 and unintended pregnancy, did not want to be pregnant then or any time in the future, are current epidemics that differentially affect @entity0 based on sociodemographic factors. We aim to explore unintended pregnancy and contraceptive use among @entity1 and nonobese @entity0 in Los Angeles County. METHODS: We analyzed the 2012 Los Angeles Mommy and Baby data. Los Angeles Mommy and Baby is a population-based surveillance system designed to monitor self-reported experiences occurring before, during, and after pregnancy.    tests and logistic regression assessed differences between @entity1 and nonobese mothers. Analyses were conducted using sampling weights to account for the complex sampling scheme. RESULTS: There were 6,843 respondents to the 2012 Los Angeles Mommy and Baby survey. Overall, 48% of births in Los Angeles County were unintended. Mothers who were @entity1 were 1.1 times (P<.001) more likely to have an unintended pregnancy compared with mothers who were not @entity1 . Overweight @entity0 (body mass index [BMI, calculated as weight (kg)/[height (m)]] between 25.0 and 29.9) were 1.3 times more likely to not use any method of birth control than normal-weight @entity0 (BMI less than 25). Obese @entity0 (BMI greater than 30) were 1.1 times more likely to not use contraception than normal-weight @entity0 . CONCLUSION: @entity1 in mothers was associated with an increased chance of unintended pregnancy. Both overweight and @entity1 @entity0 were more likely to report not having used birth control before pregnancy than normal-weight @entity0 . To reduce the number of unintended pregnancies in Los Angeles County, it is important to educate overweight and @entity1 mothers about the significance of contraceptive methods.

title: Maternal XXXX and Its Association With Unintended Pregnancies and Contraceptive Use [273].

answer: @entity1


abstract: INTRODUCTION: A variety of treatment approaches are available for @entity1 . Many specialties are involved in their management, but criteria for early recognition of high-risk @entity0 and prompt referral guidelines do not exist. METHODS: A retrospective cohort of @entity1 cases treated at a single, urban tertiary care center from 2011 to 2013 was identified. Analyses were completed on two groups: pediatric (younger than 18 years old) and adults (older than 18 years old). Univariate analyses examined @entity0 factors associated with length of stay. RESULTS: A total of 250 @entity0 with @entity1 were identified. Of those, 54 (25%) were pediatric @entity0 with a mean age of 5 years (standard deviation [SD] 5.6), and 196 (75%) were adults with a mean age 43 years (SD 17.8, range 18-95 years). The prevalence of length of stay of 1 or more days was 57% (n=31) in the pediatric group, and the majority were managed with a surgical procedure (97.8% [53/54]) by nongynecologic surgeons (95.4%). In the adult population, the prevalence of length of stay of 1 or more days was 27% (n=53), and 74.4% (133/180) of adult @entity0 had operative procedures performed by a gynecologist. Characteristics that predicted length of stay of 1 or more days were two preoperative comorbidities for @entity0 (odds ratio [OR] 2.07, 95% confidence interval [CI] 1.59-3.37) and seven comorbidities for adult @entity0 (OR 4.9, 95% CI 6.64-8.00). An increasing trend between comorbidities and number of procedures performed was demonstrated (r=0.497, P=.01). CONCLUSION: This study identified a subset of high-risk @entity0 with @entity1 who would benefit from earlier treatment and more specialized services and interventions.

title: When Should Gynecology Be Consulted to Manage a XXXX ? [301].

answer: @entity1


abstract: BACKGROUND: The shift towards earlier stages of disease advancement at diagnosis when introducing mammography screening is expected to affect the treatment costs of @entity0 . MATERIALS AND METHODS: We collected data on hospital resource use in Norway following a @entity0 diagnosis for the period 1 January, 2008 through 31 December, 2009 for @entity1 aged 50-69  years, diagnosed with @entity0 during the period 1 January, 1999 through 31 December, 2009. We estimated treatment costs using a function that included the probability of being at risk for receiving treatment, estimated by means of the Cox proportional hazard model. RESULTS: In total, 16,045 @entity1 were included for the analyses among which 10.5  % died during the study period. The mean 10-year per- @entity1 treatment cost was < @entity4 >31,940 (95  % CI < @entity4 >31,030-32,880), and lower for @entity2 detected within the public screening program (< @entity4 >30,730) than for those detected elsewhere (< @entity4 >36,230). For @entity3 in situ (DCIS) and @entity2 in stages I thru IV, treatment costs were < @entity4 >15,740, < @entity4 >23,570, < @entity4 >46,550, < @entity4 >55,230 and < @entity4 >60,430, respectively. @entity2 occurring within the screening program were generally more resource demanding than both @entity2 detected at screening or elsewhere. CONCLUSIONS: Ten-year treatment costs increased by increasing stage at diagnosis. @entity1 whose @entity2 was detected within the public screening program had lower treatment costs than those detected elsewhere. @entity2 had higher costs than others.

title: Expected 10-year treatment cost of XXXX detected within and outside a public screening program in Norway.

answer: @entity0


abstract: PURPOSE: @entity3 is associated with a variety of diseases. @entity3 on in vivo imaging may facilitate the early detection and treatment of @entity4 . Although routinely used in thoracic imaging, computed tomography has thus far not been compellingly shown to characterize @entity2 in vivo. Alternatively, magnetic resonance imaging (MRI) is a nonionizing radiation technique to better visualize and characterize pulmonary tissue. Prior to routine adoption of MRI for early characterization of @entity2 in @entity0 , a rigorous and quantitative characterization of the utility of MRI to identify @entity2 is required. Such characterization may be achieved by considering ex vivo histology as the ground truth, since it enables the definitive spatial assessment of @entity2 . In this study, the authors introduce a novel framework to integrate 2D histology, ex vivo and in vivo imaging to enable the mapping of the extent of disease from ex vivo histology onto in vivo imaging, with the goal of facilitating computerized feature analysis and interrogation of disease appearance on in vivo imaging. The authors' framework was evaluated in a preclinical preliminary study aimed to identify computer extracted features on in vivo MRI associated with @entity3 . METHODS: The authors' image analytics framework first involves reconstructing the histologic volume in 3D from individual histology slices. Second, the authors map the disease ground truth onto in vivo MRI via coregistration with 3D histology using the ex vivo lung MRI as a conduit. Finally, computerized feature analysis of the disease extent is performed to identify candidate in vivo imaging signatures of disease presence and extent. RESULTS: The authors evaluated the framework by assessing the quality of the 3D histology reconstruction and the histology-MRI fusion, in the context of an initial use case involving characterization of @entity2 in a @entity1 model. The authors' evaluation considered three @entity1 , two with an @entity2 phenotype and one control. The authors' iterative 3D histology reconstruction yielded a 70.1%    2.7% overlap with the ex vivo MRI volume. Across a total of 17 anatomic landmarks manually delineated at the division of airways, the target registration error between the ex vivo MRI and 3D histology reconstruction was 0.85    0.44 mm, suggesting that a good alignment of the ex vivo 3D histology and ex vivo MRI had been achieved. The 3D histology-in vivo MRI coregistered volumes resulted in an overlap of 73.7%    0.9%. Preliminary computerized feature analysis was performed on an additional four control @entity1 , for a total of seven @entity1 considered in this study. Gabor texture filters appeared to best capture differences between the inflamed and noninflamed regions on MRI. CONCLUSIONS: The authors' 3D histology reconstruction and multimodal registration framework were successfully employed to reconstruct the histology volume of the lung and fuse it with in vivo MRI to create a ground truth map for @entity2 on in vivo MRI. The analytic platform presented here lays the framework for a rigorous validation of the identified imaging features for @entity3 on MRI in a large prospective cohort.

title: Framework for 3D histologic reconstruction and fusion with in vivo MRI: Preliminary results of XXXX in a @entity1 model.

answer: @entity3


abstract: PURPOSE: @entity3 is associated with a variety of diseases. @entity3 on in vivo imaging may facilitate the early detection and treatment of @entity4 . Although routinely used in thoracic imaging, computed tomography has thus far not been compellingly shown to characterize @entity2 in vivo. Alternatively, magnetic resonance imaging (MRI) is a nonionizing radiation technique to better visualize and characterize pulmonary tissue. Prior to routine adoption of MRI for early characterization of @entity2 in @entity0 , a rigorous and quantitative characterization of the utility of MRI to identify @entity2 is required. Such characterization may be achieved by considering ex vivo histology as the ground truth, since it enables the definitive spatial assessment of @entity2 . In this study, the authors introduce a novel framework to integrate 2D histology, ex vivo and in vivo imaging to enable the mapping of the extent of disease from ex vivo histology onto in vivo imaging, with the goal of facilitating computerized feature analysis and interrogation of disease appearance on in vivo imaging. The authors' framework was evaluated in a preclinical preliminary study aimed to identify computer extracted features on in vivo MRI associated with @entity3 . METHODS: The authors' image analytics framework first involves reconstructing the histologic volume in 3D from individual histology slices. Second, the authors map the disease ground truth onto in vivo MRI via coregistration with 3D histology using the ex vivo lung MRI as a conduit. Finally, computerized feature analysis of the disease extent is performed to identify candidate in vivo imaging signatures of disease presence and extent. RESULTS: The authors evaluated the framework by assessing the quality of the 3D histology reconstruction and the histology-MRI fusion, in the context of an initial use case involving characterization of @entity2 in a @entity1 model. The authors' evaluation considered three @entity1 , two with an @entity2 phenotype and one control. The authors' iterative 3D histology reconstruction yielded a 70.1%    2.7% overlap with the ex vivo MRI volume. Across a total of 17 anatomic landmarks manually delineated at the division of airways, the target registration error between the ex vivo MRI and 3D histology reconstruction was 0.85    0.44 mm, suggesting that a good alignment of the ex vivo 3D histology and ex vivo MRI had been achieved. The 3D histology-in vivo MRI coregistered volumes resulted in an overlap of 73.7%    0.9%. Preliminary computerized feature analysis was performed on an additional four control @entity1 , for a total of seven @entity1 considered in this study. Gabor texture filters appeared to best capture differences between the inflamed and noninflamed regions on MRI. CONCLUSIONS: The authors' 3D histology reconstruction and multimodal registration framework were successfully employed to reconstruct the histology volume of the lung and fuse it with in vivo MRI to create a ground truth map for @entity2 on in vivo MRI. The analytic platform presented here lays the framework for a rigorous validation of the identified imaging features for @entity3 on MRI in a large prospective cohort.

title: Framework for 3D histologic reconstruction and fusion with in vivo MRI: Preliminary results of @entity3 in a XXXX model.

answer: @entity1


abstract: AIM: To record in real life the appreciation of elderly @entity0 , their caregivers and physicians of a once daily formulation of prolonged release of @entity4 in the treatment of mild to moderate @entity1 . METHODS: A prospective, multicenter, observational study was conducted in 128 elderly @entity0 , treated for 6 months with @entity4 , @entity2 or @entity3 . RESULTS: Of the @entity0 treated with @entity4 , 82 of the 97 (84.5%) were continuing their treatment after 6 months. These @entity0 reported their condition as improved in 49%, unchanged in 47% and worsened in 4%. Caregivers rated global evaluation as 37% better, 41% unchanged and 22% worse. Physicians rated global clinical impression of change as 46% better, 34% unchanged and 20% worse. Measurements of cognition and behavior remained stable. The appreciation of physicians and caregivers corresponded well (P<0.001). The incidence of serious side-effects possibly related to @entity4 was 9.3%, which was not different from that in @entity0 treated with other cholinesterase inhibitors. CONCLUSION: In a real life setting, @entity4 once daily is safe and is favorably appreciated by @entity0 , their caregivers and physicians.

title: @entity4 ( @entity4 ) once daily outcome and satisfaction survey (RODOS) in mild to moderate XXXX : a study in a real life population.

answer: @entity1


abstract: AIM: To record in real life the appreciation of elderly @entity0 , their caregivers and physicians of a once daily formulation of prolonged release of @entity4 in the treatment of mild to moderate @entity1 . METHODS: A prospective, multicenter, observational study was conducted in 128 elderly @entity0 , treated for 6 months with @entity4 , @entity2 or @entity3 . RESULTS: Of the @entity0 treated with @entity4 , 82 of the 97 (84.5%) were continuing their treatment after 6 months. These @entity0 reported their condition as improved in 49%, unchanged in 47% and worsened in 4%. Caregivers rated global evaluation as 37% better, 41% unchanged and 22% worse. Physicians rated global clinical impression of change as 46% better, 34% unchanged and 20% worse. Measurements of cognition and behavior remained stable. The appreciation of physicians and caregivers corresponded well (P<0.001). The incidence of serious side-effects possibly related to @entity4 was 9.3%, which was not different from that in @entity0 treated with other cholinesterase inhibitors. CONCLUSION: In a real life setting, @entity4 once daily is safe and is favorably appreciated by @entity0 , their caregivers and physicians.

title: XXXX ( @entity4 ) once daily outcome and satisfaction survey (RODOS) in mild to moderate @entity1 : a study in a real life population.

answer: @entity4


abstract: AIM: To record in real life the appreciation of elderly @entity0 , their caregivers and physicians of a once daily formulation of prolonged release of @entity4 in the treatment of mild to moderate @entity1 . METHODS: A prospective, multicenter, observational study was conducted in 128 elderly @entity0 , treated for 6 months with @entity4 , @entity2 or @entity3 . RESULTS: Of the @entity0 treated with @entity4 , 82 of the 97 (84.5%) were continuing their treatment after 6 months. These @entity0 reported their condition as improved in 49%, unchanged in 47% and worsened in 4%. Caregivers rated global evaluation as 37% better, 41% unchanged and 22% worse. Physicians rated global clinical impression of change as 46% better, 34% unchanged and 20% worse. Measurements of cognition and behavior remained stable. The appreciation of physicians and caregivers corresponded well (P<0.001). The incidence of serious side-effects possibly related to @entity4 was 9.3%, which was not different from that in @entity0 treated with other cholinesterase inhibitors. CONCLUSION: In a real life setting, @entity4 once daily is safe and is favorably appreciated by @entity0 , their caregivers and physicians.

title: @entity4 ( XXXX ) once daily outcome and satisfaction survey (RODOS) in mild to moderate @entity1 : a study in a real life population.

answer: @entity4