abstract: @entity5 is a major, urgent @entity0 in which reactive @entity2 species (ROS) are deeply involved in the detrimental effects. @entity6 nanoparticle (nPt) species are a novel and strong scavenger of such ROS, so we examined the clinical and neuroprotective effects of nPts in @entity1 @entity3 brain. @entity1 were subjected to transient @entity9 (tMCAO) for 60 min. Upon reperfusion, nPt or vehicle was administered intravenously. At 48 hr after the tMCAO, motor function, @entity7 volume, immunohistochemistry of neurovascular components (endothelial NAGO, tight junctional occludin, and basal laminal collagen IV), and zymography for @entity8 activity were examined. @entity4 anion generation at 2 hr after tMCAO was determined with oxidized @entity10 . Compared with vehicle, treatment with nPts significantly improved the motor function and greatly reduced the @entity7 volume, especially in the cerebral cortex. Immunohistochemical analyses revealed that tMCAO resulted in a minimal decrease of NAGO and occludin but a great decrease of collagen IV and a remarkable increase of @entity8 . Treatment with nPts greatly reduced this decrease of collagen IV and activation of @entity8 and, with large reductions of @entity8 activation on zymography and @entity4 production. The present study demonstrates that treatment with nPts ameliorates the neurological scores with a large reduction in @entity7 size as well as the preservation of outer components of the neurovascular unit (collagen IV) and inactivation of @entity8 . A strong reduction of @entity4 anion production by nPts could account for such remarkable neurobehavioral and neuroprotective effects on @entity5 .

title: Neurological and pathological improvements of @entity5 in XXXX with @entity6 nanoparticles.

answer: @entity1


abstract: AIM: To detect and verify the existence of a specific form of T-cell @entity1 accompanied by @entity2 of bone marrow and @entity6 . MATERIAL AND METHODS: Four @entity0 with @entity6 were examined using clinical, histological, cytological, cytogenetic, and immunophenotypic methods. RESULTS: Four cases of @entity1 of bone marrow with clinical and morphological manifestations of @entity6 and scanty proliferation activity in bone marrow alone were diagnosed. The proliferation activity in bone marrow was observed as formation of small clusters composed of small-size lymphoid cells with dense nucleus. Dynamic monitoring of two @entity0 revealed a trend toward an increase in the lymphoproliferation base against the remaining clinical picture of @entity6 . The T-cell immunophenotype characterized by disappearance of some markers or decrease in their density, was observed only in some blood and bone marrow lymphocytes. The most significant changes of immunophenotype were observed in one of the @entity0 (CD2+CD3-CD4-CD5-CD7-CD8-CD16-CD56-CD45RO++). The same @entity0 had pronounced cytogenetic changes (47XY+Y[8], 47, XY, del(1)( @entity7 ) [23], 46 XY [3]) and resistance to routine therapy, including @entity3 . In one @entity0 the process transformed into @entity5 . CONCLUSION: The results obtained in four @entity0 allow their clinicomorphological characteristics to be regarded as particular forms of @entity1 accompanied by @entity4 and @entity6 .

title: [ @entity1 with XXXX ].

answer: @entity6


abstract: AIM: To detect and verify the existence of a specific form of T-cell @entity1 accompanied by @entity2 of bone marrow and @entity6 . MATERIAL AND METHODS: Four @entity0 with @entity6 were examined using clinical, histological, cytological, cytogenetic, and immunophenotypic methods. RESULTS: Four cases of @entity1 of bone marrow with clinical and morphological manifestations of @entity6 and scanty proliferation activity in bone marrow alone were diagnosed. The proliferation activity in bone marrow was observed as formation of small clusters composed of small-size lymphoid cells with dense nucleus. Dynamic monitoring of two @entity0 revealed a trend toward an increase in the lymphoproliferation base against the remaining clinical picture of @entity6 . The T-cell immunophenotype characterized by disappearance of some markers or decrease in their density, was observed only in some blood and bone marrow lymphocytes. The most significant changes of immunophenotype were observed in one of the @entity0 (CD2+CD3-CD4-CD5-CD7-CD8-CD16-CD56-CD45RO++). The same @entity0 had pronounced cytogenetic changes (47XY+Y[8], 47, XY, del(1)( @entity7 ) [23], 46 XY [3]) and resistance to routine therapy, including @entity3 . In one @entity0 the process transformed into @entity5 . CONCLUSION: The results obtained in four @entity0 allow their clinicomorphological characteristics to be regarded as particular forms of @entity1 accompanied by @entity4 and @entity6 .

title: [ XXXX with @entity6 ].

answer: @entity1


abstract: The aims of the study were to evaluate the short-term effects of a new thermosensitive, @entity2 (V-E) mousse on local free radicals (FR) and skin flux in @entity3 . A group of 40 @entity0 with @entity3 was included. The variation in measurements of skin FR was evaluated by the D-Rom test. Subjects were between 45 and 65 years with @entity5 and good metabolic control. E-mousse, a thermoactive preparation of acetate @entity2 (20%), was applied twice daily on the whole surface of the leg (below knee) and foot for 3 weeks. The contralateral leg was untreated acting as control. Subjects with age between 45 and 65 years with @entity5 (diagnosed at least 5 years before) and good metabolic control (blood sugar < 180 mg/dL) were included after informed consent. @entity0 with uncontrolled @entity1 , @entity4 , and severe lower limbs infections were excluded. Local free radicals (FR) and laser Doppler flux including the venoarteriolar response (VAR) were evaluated. The tolerability was evaluated by a semiquantitative score. Of the 40 included @entity0 34 completed the study. The 2 groups were comparable. At 3 weeks there was no decrease in FR in controls; the decrease in the treatment group was 45.3% (p < 0.05). Also in the treatment group RF decreased (p < 0.05) and the VARveno improved from an average of 21% to an average of 38% (p < 0.05). No significant variations were observed in the control group. The variation in symptomatic score was from a total value of 8 to 5 in the control group and from 8 to 1 in the treatment group (p < 0.02). Their tolerability was good. In conclusion local treatment with E-mousse for 3 weeks in @entity3 improves skin microcirculation and the metabolic condition as shown by the decrease in FR.

title: Evaluation of the local effects of @entity2 (E-Mousse) on free radicals in XXXX : a randomized, controlled trial.

answer: @entity3


abstract: The aims of the study were to evaluate the short-term effects of a new thermosensitive, @entity2 (V-E) mousse on local free radicals (FR) and skin flux in @entity3 . A group of 40 @entity0 with @entity3 was included. The variation in measurements of skin FR was evaluated by the D-Rom test. Subjects were between 45 and 65 years with @entity5 and good metabolic control. E-mousse, a thermoactive preparation of acetate @entity2 (20%), was applied twice daily on the whole surface of the leg (below knee) and foot for 3 weeks. The contralateral leg was untreated acting as control. Subjects with age between 45 and 65 years with @entity5 (diagnosed at least 5 years before) and good metabolic control (blood sugar < 180 mg/dL) were included after informed consent. @entity0 with uncontrolled @entity1 , @entity4 , and severe lower limbs infections were excluded. Local free radicals (FR) and laser Doppler flux including the venoarteriolar response (VAR) were evaluated. The tolerability was evaluated by a semiquantitative score. Of the 40 included @entity0 34 completed the study. The 2 groups were comparable. At 3 weeks there was no decrease in FR in controls; the decrease in the treatment group was 45.3% (p < 0.05). Also in the treatment group RF decreased (p < 0.05) and the VARveno improved from an average of 21% to an average of 38% (p < 0.05). No significant variations were observed in the control group. The variation in symptomatic score was from a total value of 8 to 5 in the control group and from 8 to 1 in the treatment group (p < 0.02). Their tolerability was good. In conclusion local treatment with E-mousse for 3 weeks in @entity3 improves skin microcirculation and the metabolic condition as shown by the decrease in FR.

title: Evaluation of the local effects of XXXX (E-Mousse) on free radicals in @entity3 : a randomized, controlled trial.

answer: @entity2


abstract: BACKGROUND: @entity0 is the second leading cause of @entity2 among @entity1 in the United States. Although the incidence of @entity0 is 13% higher in white @entity1 , mortality in black @entity1 is 28% higher, due to histological and socioeconomic factors. Existing research regarding racial differences in compliance with @entity0 screening recommendations has found conflicting results. METHODS: Data on more than 4,500 @entity1 were taken from the 1992 National Health Interview Survey, a nationally representative, population-based sample survey. Logistic regression was used to estimate the relative odds of knowledge of @entity0 ( @entity0 ) and mammograms, and compliance with @entity0 , clinical breast exams (CBE), and mammograms. RESULTS: Black @entity1 were less likely than white @entity1 to be aware of and use @entity0 screening tests. However, among @entity1 who were aware of screening tests, compliance was higher among black @entity1 . @entity1 with low educational attainment, low @entity2 knowledge, and no usual source of care were less likely to be CBE or mammogram compliant. Socioeconomic differences were larger for the two clinical tests than for @entity0 . CONCLUSIONS: Programs should inform @entity1 about @entity2 screening tests and remove barriers that hinder @entity1 from receiving clinical screening exams.

title: Racial differences in XXXX screening, knowledge and compliance.

answer: @entity0


abstract: BACKGROUND: The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT) because of its ability to deliver highly conformal radiation therapy to moving targets. This conformity is achieved via 100s of non-coplanar radiation beams, which could potentially increase transitory testicular irradiation and result in post-therapy @entity4 . We report on our early experience with CyberKnife SBRT for low- to intermediate-risk @entity3 @entity0 and assess the rate of inducing biochemical and clinical @entity4 . METHODS: Twenty-six @entity0 were treated with hypofractionated SBRT to a dose of 36.25 Gy in 5 fractions. All @entity0 had histologically confirmed low- to intermediate-risk @entity3 (clinical stage  <= T2b, Gleason score  <= 7, PSA  <= 20 ng/ml). PSA and total @entity2 levels were obtained pre-treatment, 1 month post-treatment and every 3 months thereafter, for 1 year. Biochemical @entity4 was defined as a total serum @entity2 level below 8 nmol/L. Urinary and gastrointestinal @entity1 was assessed using Common @entity1 Criteria v3; quality of life was assessed using the American Urological Association Symptom Score, Sexual Health Inventory for @entity0 and Expanded @entity3 Index Composite questionnaires. RESULTS: All 26 @entity0 completed the treatment with a median 15 months (range, 13-19 months) follow-up. Median pre-treatment PSA was 5.75 ng/ml (range, 2.3-10.3 ng/ml), and a decrease to a median of 0.7 ng/ml (range, 0.2-1.8 ng/ml) was observed by one year post-treatment. The median pre-treatment total serum @entity2 level was 13.81 nmol/L (range, 5.55 - 39.87 nmol/L). Post-treatment @entity2 levels slowly decreased with the median value at one year follow-up of 10.53 nmol/L, significantly lower than the pre-treatment value (p < 0.013). The median absolute fall was 3.28 nmol/L and the median percent fall was 23.75%. There was no increase in biochemical @entity4 at one year post-treatment. Average EPIC sexual and hormonal scores were not significantly changed by one year post-treatment. CONCLUSIONS: Hypofractionated SBRT offers the radiobiological benefit of a large fraction size and is well-tolerated by @entity0 with low- to intermediate-risk @entity3 . Early results are encouraging with an excellent biochemical response. The rate of new biochemical and clinical @entity4 was low one year after treatment.

title: Low incidence of new biochemical and clinical @entity4 following hypofractionated stereotactic body radiation therapy (SBRT) monotherapy for low- to intermediate-risk XXXX .

answer: @entity3


abstract: BACKGROUND: The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT) because of its ability to deliver highly conformal radiation therapy to moving targets. This conformity is achieved via 100s of non-coplanar radiation beams, which could potentially increase transitory testicular irradiation and result in post-therapy @entity4 . We report on our early experience with CyberKnife SBRT for low- to intermediate-risk @entity3 @entity0 and assess the rate of inducing biochemical and clinical @entity4 . METHODS: Twenty-six @entity0 were treated with hypofractionated SBRT to a dose of 36.25 Gy in 5 fractions. All @entity0 had histologically confirmed low- to intermediate-risk @entity3 (clinical stage  <= T2b, Gleason score  <= 7, PSA  <= 20 ng/ml). PSA and total @entity2 levels were obtained pre-treatment, 1 month post-treatment and every 3 months thereafter, for 1 year. Biochemical @entity4 was defined as a total serum @entity2 level below 8 nmol/L. Urinary and gastrointestinal @entity1 was assessed using Common @entity1 Criteria v3; quality of life was assessed using the American Urological Association Symptom Score, Sexual Health Inventory for @entity0 and Expanded @entity3 Index Composite questionnaires. RESULTS: All 26 @entity0 completed the treatment with a median 15 months (range, 13-19 months) follow-up. Median pre-treatment PSA was 5.75 ng/ml (range, 2.3-10.3 ng/ml), and a decrease to a median of 0.7 ng/ml (range, 0.2-1.8 ng/ml) was observed by one year post-treatment. The median pre-treatment total serum @entity2 level was 13.81 nmol/L (range, 5.55 - 39.87 nmol/L). Post-treatment @entity2 levels slowly decreased with the median value at one year follow-up of 10.53 nmol/L, significantly lower than the pre-treatment value (p < 0.013). The median absolute fall was 3.28 nmol/L and the median percent fall was 23.75%. There was no increase in biochemical @entity4 at one year post-treatment. Average EPIC sexual and hormonal scores were not significantly changed by one year post-treatment. CONCLUSIONS: Hypofractionated SBRT offers the radiobiological benefit of a large fraction size and is well-tolerated by @entity0 with low- to intermediate-risk @entity3 . Early results are encouraging with an excellent biochemical response. The rate of new biochemical and clinical @entity4 was low one year after treatment.

title: Low incidence of new biochemical and clinical XXXX following hypofractionated stereotactic body radiation therapy (SBRT) monotherapy for low- to intermediate-risk @entity3 .

answer: @entity4


abstract: The effect of physical training on the time course of sweat rate in @entity0 has been examined. Physically untrained and trained young female subjects pedaled a bicycle ergometer at work rates of 483 and 981 kgm. @entity1 , for 2 h in summer and winter in an ambient environment of 30 degrees C db and 60% rh. The trained @entity0 also worked at 1,070 kgm. @entity1 and the untrained at 391 kgm. @entity1 . Rectal temperature was measured, and capsule sweat samples were collected from the back every 5 min. Sweating was initiated more rapidly in the trained group than in the untrained group. The trained group working at a load of 981 kgm. @entity1 exhibited a progressive decrease in sweat rate. This was not observed at a work load of 483 kgm. @entity1 . Hidromeiosis was rarely seen in the untrained group. However, in the untrained @entity0 who underwent 60 days of physical training, initiation of sweating occurred more quickly and hidromeiosis was observed. It was concluded that previous physical training improved @entity0 's capacity for useful sweating during exercise in a hot environment.

title: Effect of physical training on exercise-induced sweating in XXXX .

answer: @entity0


abstract: The treatment of dysthymia in itself poses a problem in the everyday @entity5 practice and it can be further hindered when accompanied by pronounced personality traits (which are @entity3 ). Due to its @entity6 interferes with the @entity0 's quality of life and the ability to function in some segments of everyday life. These interferences enticed our @entity0 to opt for @entity5 treatment. During a three-year period, despite all the efforts made by psychiatrists in this comprehensive and challenging dysthymia treatment (psychotherapy, group psychotherapy, psychopharmacotherapy), the expected outcomes of the treatment did not occur. The @entity0 's goals and expectations included lifestyle change, achieving life satisfaction and mood improvement. The @entity0 was refusing suggested psychopharmaca until confronted, in psychotherapy, with the fact that she is the one prolonging her own helplessness and directing her passive agression at the members of the group. In the end the patent agreed to take psychopharmaca. Therefore, sertraline was introduced in the treatment, but the @entity0 experienced a severe @entity2 (Qiuncke's @entity1 ). After four months the second attempt was made and escitaloptam was introduced, which resulted in @entity4 . Due to these @entity2 to antidepressants, the @entity0 decided not to pursue the psychopharmacological treatment.

title: XXXX --outcome of sertraline and escitalopram treatments.

answer: @entity2


abstract: BACKGROUND: The clearance of surgical margins at the primary site is widely thought to influence the subsequent course of the disease in @entity0 operated on for oral and @entity3 . In some reports the adverse impact of close or involved margins was not negated by postoperative radiotherapy. These findings, in addition to descriptive histopathological studies, have led some authors to recommend margins of more than a macroscopic clearance of 1cm at certain subsites. We have therefore examined the relation between the condition of surgical margins and local recurrence and disease-specific survival. METHODS: Identical treatment protocols were used to treat two independent groups of @entity0 (Sydney, Australia, n=237; Lanarkshire, n=95) who presented with previously untreated @entity4 or oropharynx. All @entity0 were operated on with the primary objective of achieving a macroscopic clearance of 1cm. Postoperative radiotherapy was used according to a protocol. Data about @entity0 were entered into comprehensive computerised databases prospectively. Known clinical and pathological prognostic indicators, in addition to the condition of surgical margins, were analysed to find out if they were predictive of local recurrence and disease-specific survival using the Cox proportional hazard model. RESULTS: Local recurrence was predicted by the presence of perineural invasion at the primary site in both groups. Disease-specific survival was predicted by the presence and extent of regional lymph node @entity1 in both groups. The condition of surgical margins (clear, close, or involved) did not predict local recurrence, or disease-specific survival on multivariate analysis. CONCLUSIONS: A macroscopic margin of 1cm seems adequate in the surgical management of oral and @entity3 . For most @entity0 who have close or involved margins the biology of the disease influences the subsequent course irrespective of the width of clearance of @entity2 .

title: Influence of condition of surgical margins on local recurrence and disease-specific survival in oral and XXXX .

answer: @entity2


abstract: BACKGROUND: @entity3 is the most common gynecologic malignancy in the developed countries. Clinical studies have shown that early stage uterine @entity2 (USC) has outcomes similar to early stage high grade @entity4 ( @entity5 ) than to early stage low grade @entity4 ( @entity5 ). However, little is known about the origin of these different clinical outcomes. This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n=11) relative to stage I @entity5 (n=11) and stage I @entity5 (n=11), respectively. METHODOLOGY/PRINCIPAL FINDING: We found that the expression difference between USC and @entity5 , as measured by the number of differentially expressed genes (DEGs), is consistently less than that found between USC and @entity5 . Pathway enrichment analyses suggested that DEGs specific to USC vs. @entity5 are enriched for genes involved in signaling transduction, while DEGs specific to USC vs. @entity5 are enriched for genes involved in cell cycle. Gene expression differences for selected DEGs are confirmed by quantitative RT-PCR with a high validation rate. CONCLUSION: This data, although preliminary, indicates that stage I USC is genetically similar to stage I @entity5 compared to stage I @entity5 . DEGs identified from this study might provide an insight in to the potential mechanisms that influence the clinical outcome differences between @entity3 subtypes. They might also have potential prognostic and therapeutic impacts on @entity0 diagnosed with uterine @entity1 .

title: Gene expression profiles in stage I uterine @entity2 in comparison to grade 3 and grade 1 stage I XXXX .

answer: @entity4


abstract: BACKGROUND: @entity3 is the most common gynecologic malignancy in the developed countries. Clinical studies have shown that early stage uterine @entity2 (USC) has outcomes similar to early stage high grade @entity4 ( @entity5 ) than to early stage low grade @entity4 ( @entity5 ). However, little is known about the origin of these different clinical outcomes. This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n=11) relative to stage I @entity5 (n=11) and stage I @entity5 (n=11), respectively. METHODOLOGY/PRINCIPAL FINDING: We found that the expression difference between USC and @entity5 , as measured by the number of differentially expressed genes (DEGs), is consistently less than that found between USC and @entity5 . Pathway enrichment analyses suggested that DEGs specific to USC vs. @entity5 are enriched for genes involved in signaling transduction, while DEGs specific to USC vs. @entity5 are enriched for genes involved in cell cycle. Gene expression differences for selected DEGs are confirmed by quantitative RT-PCR with a high validation rate. CONCLUSION: This data, although preliminary, indicates that stage I USC is genetically similar to stage I @entity5 compared to stage I @entity5 . DEGs identified from this study might provide an insight in to the potential mechanisms that influence the clinical outcome differences between @entity3 subtypes. They might also have potential prognostic and therapeutic impacts on @entity0 diagnosed with uterine @entity1 .

title: Gene expression profiles in stage I uterine XXXX in comparison to grade 3 and grade 1 stage I @entity4 .

answer: @entity2


abstract: BACKGROUND: The efficacy of @entity4 mofetil ( @entity2 ) plus interferon beta-1a (IFNB-1a) in treatment of @entity3 ( @entity3 ) was evaluated. METHODS: This was a pilot study with randomized, double-blinded, placebo-controlled design. @entity0 with @entity3 and Expanded Disability Status Scale score (EDSS) of < 6.0 were included. Those with relapse within the previous two months and prior use of immunomodulatory/immunosuppressive drugs were excluded. @entity0 were randomized into @entity2 (n = 13) and placebo (n = 13) groups and received weekly intramuscular IFNB-1a plus either @entity2 or placebo. @entity2 started by 500 mg/d for one week and weekly escalated by 500 mg/d, until target divided dose of 2000 mg/d and continued for 12 months. Radiologic and clinical assessments were performed at baseline and then at month 12. RESULTS: After one year of therapy, difference between the two groups in number of new T2 lesions was not statistically significant (0.54    0.77 in @entity2 vs. 1.85    3.2 in placebo group, p = 0.169). Two @entity0 in the placebo group had gadoliniumenhanced lesions and one @entity0 had relapse. There were 3 @entity0 in each group with more than one point progression in EDSS. Common side effect in the @entity2 group included @entity1 , but no @entity0 discontinued the treatment. CONCLUSIONS: Combination of @entity2 with IFNB-1a in @entity0 with @entity3 is well tolerated, but the efficacy of such combination was not statistically significant in this pilot study and deserves further investigation with a larger sample size and a longer follow-up.

title: XXXX mofetil in combination with interferon beta-1a in the treatment of @entity3 : A preliminary study.

answer: @entity4


abstract: BACKGROUND: The efficacy of @entity4 mofetil ( @entity2 ) plus interferon beta-1a (IFNB-1a) in treatment of @entity3 ( @entity3 ) was evaluated. METHODS: This was a pilot study with randomized, double-blinded, placebo-controlled design. @entity0 with @entity3 and Expanded Disability Status Scale score (EDSS) of < 6.0 were included. Those with relapse within the previous two months and prior use of immunomodulatory/immunosuppressive drugs were excluded. @entity0 were randomized into @entity2 (n = 13) and placebo (n = 13) groups and received weekly intramuscular IFNB-1a plus either @entity2 or placebo. @entity2 started by 500 mg/d for one week and weekly escalated by 500 mg/d, until target divided dose of 2000 mg/d and continued for 12 months. Radiologic and clinical assessments were performed at baseline and then at month 12. RESULTS: After one year of therapy, difference between the two groups in number of new T2 lesions was not statistically significant (0.54    0.77 in @entity2 vs. 1.85    3.2 in placebo group, p = 0.169). Two @entity0 in the placebo group had gadoliniumenhanced lesions and one @entity0 had relapse. There were 3 @entity0 in each group with more than one point progression in EDSS. Common side effect in the @entity2 group included @entity1 , but no @entity0 discontinued the treatment. CONCLUSIONS: Combination of @entity2 with IFNB-1a in @entity0 with @entity3 is well tolerated, but the efficacy of such combination was not statistically significant in this pilot study and deserves further investigation with a larger sample size and a longer follow-up.

title: @entity4 mofetil in combination with interferon beta-1a in the treatment of XXXX : A preliminary study.

answer: @entity3


abstract: BACKGROUND: @entity0 endeavors to prevent @entity4 have led to the use of different modalities and agents, the most commonly used of which is fluoridated dentifrice. An in situ study was carried out to evaluate the efficacy of fluoridated dentifrices in achieving remineralization of @entity2 using surface microhardness measurements and to study the qualitative changes by scan-ning electron microscopy. METHODS: Sixteen @entity0 12-16 years of age wore a specially fabricated appliance with an artificially demineralized enamel slab for 24 hours a day, for four weeks. The @entity0 were divided into two groups, A and B. Following one week use of placebo dentifrice by both groups, group A used a @entity3 dentifrice containing l000 ppm @entity5 , whereas group B used a placebo twice daily for 5 minutes for 21 days. Surface microhardness test carried out using a Knoop diamond indenter followed by scanning electron microscopy to evaluate the lesions. The results were statistically analyzed using the student t test. P value less than 0.05 was considered significant. RESULTS: The average hardness recovery for the experimental group was significantly higher than that in the control group (P < 0.001). Scanning electron microscopy revealed that @entity3 significantly enhances remineralization of @entity2 . CONCLUSION: Regular use of fluoridated dentifrices significantly enhances remineralization of @entity1 .

title: Evaluation of ability of dentifrices to remineralize XXXX .

answer: @entity2


abstract: New conditioning regimens are being explored to reduce @entity1 and enable allogeneic bone marrow transplantation in @entity0 not eligible for conventional transplantation. We have investigated @entity4 , an alkylating agent, with the aim of developing an efficient and reliable but less-toxic conditioning regimen. A series of 30 @entity0 who were not eligible for standard conditioning therapy received transplants from HLA-matched related (n = 14) or unrelated (n = 16) donors after administration of @entity4 10 g/m2 intravenously daily for 3 days and @entity3 30 mg/m2 intravenously daily for 5 days. @entity0 receiving grafts from unrelated donors also were given rabbit antithymocyte globulin 10 mg/kg intravenously daily for 3 days. All @entity0 achieved prompt neutrophil and platelet recovery. @entity1 was generally mild with Common @entity1 Criteria (CTC) grade 3 or 4 attributable to the conditioning seen only with transaminases. Complete donor chimerism was achieved by 90% of the @entity0 . @entity2 ( @entity2 ) grade III or IV developed in 14% of the @entity0 and chronic @entity2 in 39%. An estimated overall survival rate of 73% and an event-free survival rate of 49% have been reached after a median of 22 months (range, 7.4-33.4 months). In summary, the combination of @entity4 and @entity3 is a safe and efficient conditioning regimen.

title: @entity4 and @entity3 : a new XXXX -reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation.

answer: @entity1


abstract: New conditioning regimens are being explored to reduce @entity1 and enable allogeneic bone marrow transplantation in @entity0 not eligible for conventional transplantation. We have investigated @entity4 , an alkylating agent, with the aim of developing an efficient and reliable but less-toxic conditioning regimen. A series of 30 @entity0 who were not eligible for standard conditioning therapy received transplants from HLA-matched related (n = 14) or unrelated (n = 16) donors after administration of @entity4 10 g/m2 intravenously daily for 3 days and @entity3 30 mg/m2 intravenously daily for 5 days. @entity0 receiving grafts from unrelated donors also were given rabbit antithymocyte globulin 10 mg/kg intravenously daily for 3 days. All @entity0 achieved prompt neutrophil and platelet recovery. @entity1 was generally mild with Common @entity1 Criteria (CTC) grade 3 or 4 attributable to the conditioning seen only with transaminases. Complete donor chimerism was achieved by 90% of the @entity0 . @entity2 ( @entity2 ) grade III or IV developed in 14% of the @entity0 and chronic @entity2 in 39%. An estimated overall survival rate of 73% and an event-free survival rate of 49% have been reached after a median of 22 months (range, 7.4-33.4 months). In summary, the combination of @entity4 and @entity3 is a safe and efficient conditioning regimen.

title: @entity4 and XXXX : a new @entity1 -reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation.

answer: @entity3


abstract: New conditioning regimens are being explored to reduce @entity1 and enable allogeneic bone marrow transplantation in @entity0 not eligible for conventional transplantation. We have investigated @entity4 , an alkylating agent, with the aim of developing an efficient and reliable but less-toxic conditioning regimen. A series of 30 @entity0 who were not eligible for standard conditioning therapy received transplants from HLA-matched related (n = 14) or unrelated (n = 16) donors after administration of @entity4 10 g/m2 intravenously daily for 3 days and @entity3 30 mg/m2 intravenously daily for 5 days. @entity0 receiving grafts from unrelated donors also were given rabbit antithymocyte globulin 10 mg/kg intravenously daily for 3 days. All @entity0 achieved prompt neutrophil and platelet recovery. @entity1 was generally mild with Common @entity1 Criteria (CTC) grade 3 or 4 attributable to the conditioning seen only with transaminases. Complete donor chimerism was achieved by 90% of the @entity0 . @entity2 ( @entity2 ) grade III or IV developed in 14% of the @entity0 and chronic @entity2 in 39%. An estimated overall survival rate of 73% and an event-free survival rate of 49% have been reached after a median of 22 months (range, 7.4-33.4 months). In summary, the combination of @entity4 and @entity3 is a safe and efficient conditioning regimen.

title: XXXX and @entity3 : a new @entity1 -reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation.

answer: @entity4


abstract: PURPOSE: To evaluate how implementation of the 2003 American Joint Committee on @entity2 (AJCC) staging system will affect stage-specific survival of @entity0 @entity1 . @entity1 AND METHODS: Records of 1,350 @entity1 treated on sequential institutional protocols with mastectomy and adjuvant @entity4 -based chemotherapy were reviewed. Pathologic stage was assigned retrospectively according to the 1988 and the 2003 AJCC staging criteria. Overall stage-specific survival (OS) was calculated using the Kaplan-Meier method, and hypothetical differences were compared by the log-rank test. RESULTS: Six hundred five of 1,087 @entity1 with @entity3 according to the 1988 classification system had @entity3 according to the 2003 system. The 10-year OS for @entity1 with @entity3 was significantly improved using the 2003 system (76% [2003] v 65% [1988]; P <.0001). Two hundred eighty-nine of 633 @entity1 with stage IIb disease using the 1988 system were stage IIb with the 2003 system, and 10-year OS was 58% (1988) versus 70% (2003; P =.003). The number of @entity1 with stage III disease increased from 207 (1988) to 443 (2003), and the 10-year OS changed from 45% (1988) to 50% (2003; P =.077). Most of this difference resulted from changes within stage IIIa: OS, 45% (1988) versus 59% (2003; P <.0001). CONCLUSION: Stage reclassification using the new AJCC staging system for @entity0 will result in significant changes in reported outcome by stage. It is imperative that careful attention is devoted to this effect so that accurate conclusions regarding the efficacy of new treatment strategies can be drawn.

title: Changes in the 2003 American Joint Committee on @entity2 staging for XXXX dramatically affect stage-specific survival.

answer: @entity0


abstract: PURPOSE: To evaluate how implementation of the 2003 American Joint Committee on @entity2 (AJCC) staging system will affect stage-specific survival of @entity0 @entity1 . @entity1 AND METHODS: Records of 1,350 @entity1 treated on sequential institutional protocols with mastectomy and adjuvant @entity4 -based chemotherapy were reviewed. Pathologic stage was assigned retrospectively according to the 1988 and the 2003 AJCC staging criteria. Overall stage-specific survival (OS) was calculated using the Kaplan-Meier method, and hypothetical differences were compared by the log-rank test. RESULTS: Six hundred five of 1,087 @entity1 with @entity3 according to the 1988 classification system had @entity3 according to the 2003 system. The 10-year OS for @entity1 with @entity3 was significantly improved using the 2003 system (76% [2003] v 65% [1988]; P <.0001). Two hundred eighty-nine of 633 @entity1 with stage IIb disease using the 1988 system were stage IIb with the 2003 system, and 10-year OS was 58% (1988) versus 70% (2003; P =.003). The number of @entity1 with stage III disease increased from 207 (1988) to 443 (2003), and the 10-year OS changed from 45% (1988) to 50% (2003; P =.077). Most of this difference resulted from changes within stage IIIa: OS, 45% (1988) versus 59% (2003; P <.0001). CONCLUSION: Stage reclassification using the new AJCC staging system for @entity0 will result in significant changes in reported outcome by stage. It is imperative that careful attention is devoted to this effect so that accurate conclusions regarding the efficacy of new treatment strategies can be drawn.

title: Changes in the 2003 American Joint Committee on XXXX staging for @entity0 dramatically affect stage-specific survival.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: It has been suggested that the @entity2 ( @entity2 ) allele 2 is a risk factor for @entity1 ( @entity1 ). Because @entity3 ( @entity3 ) often coexists with @entity1 , we examined the @entity2 polymorphism in @entity3 . METHODS: In a case-control study, @entity0 with pathologically verified @entity3 , @entity1 @entity0 without @entity3 , and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, and @entity2 was genotyped. Logistic regression was used to examine the @entity2 polymorphism in @entity3 @entity0 with and without @entity1 compared with @entity1 and non- @entity1 control subjects. RESULTS: There were 42 @entity0 with @entity3 , 232 @entity1 @entity0 , and 167 non- @entity1 control subjects. In age-adjusted analyses, there was no association between possession of @entity2 allele 2 and risk of @entity3 compared with @entity1 control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97; P=0.87) or non- @entity1 control subjects (OR, 0.94; 95% CI, 0.47 to 1.87; P=0.86). Stratifying for the presence of apolipoprotein E epsilon2 or epsilon4 demonstrated the known increased risk of @entity3 from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of the @entity2 2,2 genotype in @entity0 with @entity3 and @entity1 compared with those @entity3 @entity0 who did not have histological evidence indicating @entity1 (OR, 2.17; 95% CI, 0.15 to 122.3; P=0.64). Comparisons between @entity3 @entity0 with @entity1 and @entity1 control subjects and between @entity3 @entity0 without @entity1 and non- @entity1 control subjects did not demonstrate an association between @entity3 and possession of either the @entity2 allele 2 or the 2,2 genotype. CONCLUSIONS: The @entity2 allele 2 or 2,2 genotype does not appear to be a major risk factor for @entity3 .

title: Association between @entity2 polymorphism and XXXX .

answer: @entity3


abstract: BACKGROUND AND PURPOSE: It has been suggested that the @entity2 ( @entity2 ) allele 2 is a risk factor for @entity1 ( @entity1 ). Because @entity3 ( @entity3 ) often coexists with @entity1 , we examined the @entity2 polymorphism in @entity3 . METHODS: In a case-control study, @entity0 with pathologically verified @entity3 , @entity1 @entity0 without @entity3 , and neuropathologically normal control subjects were studied. DNA was extracted from brain tissue, and @entity2 was genotyped. Logistic regression was used to examine the @entity2 polymorphism in @entity3 @entity0 with and without @entity1 compared with @entity1 and non- @entity1 control subjects. RESULTS: There were 42 @entity0 with @entity3 , 232 @entity1 @entity0 , and 167 non- @entity1 control subjects. In age-adjusted analyses, there was no association between possession of @entity2 allele 2 and risk of @entity3 compared with @entity1 control subjects (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.45 to 1.97; P=0.87) or non- @entity1 control subjects (OR, 0.94; 95% CI, 0.47 to 1.87; P=0.86). Stratifying for the presence of apolipoprotein E epsilon2 or epsilon4 demonstrated the known increased risk of @entity3 from these lipoprotein E alleles. Subgroup analyses demonstrated a nonsignificant excess of the @entity2 2,2 genotype in @entity0 with @entity3 and @entity1 compared with those @entity3 @entity0 who did not have histological evidence indicating @entity1 (OR, 2.17; 95% CI, 0.15 to 122.3; P=0.64). Comparisons between @entity3 @entity0 with @entity1 and @entity1 control subjects and between @entity3 @entity0 without @entity1 and non- @entity1 control subjects did not demonstrate an association between @entity3 and possession of either the @entity2 allele 2 or the 2,2 genotype. CONCLUSIONS: The @entity2 allele 2 or 2,2 genotype does not appear to be a major risk factor for @entity3 .

title: Association between XXXX polymorphism and @entity3 .

answer: @entity2


abstract: The sequence content of @entity1 L cell pre-rRNA was examined by RNA gel transfer and blot hybridization. Nuclear RNAs were separated by agarose gel electrophoresis, transferred to @entity2 -paper, and hybridized to twelve different restriction fragments that are complementary to various sections of 45S pre-rRNA. An abundant new 34S pre-rRNA and less abundant new 37S, 26S and 17S pre-rRNAs were detected. The presence of these new pre-rRNAs suggests the existence of at least two new pre-rRNA cleavage pathways. 34S and 26S pre-rRNAs were also detected in HeLa cells suggesting that these new cleavage pathways are characteristic of @entity0 cells. Further, an abundant new 12S precursor to 5.8S rRNA was also detected and is common to all the proposed cleavage pathways. The previously identified 45S, 41S, 32S and 20S pre-rRNAs were readily detected and their general structure confirmed. The 20S pre-rRNA is characteristic of the known pathway used by HeLa and other cells, and its presence suggests that growing @entity1 L cells use this pre-rRNA cleavage pathway. The 36S pre-rRNA characteristic of the previously described @entity1 L cell cleavage pathway was not detected. In all these cleavage pathways pre-rRNA cleavage sites are apparently identical and occur at or near the termini of the mature 18S, 5.8S and 28S rRNA sequences. The pathways differ only in the temporal order of cleavage at these sites. The position of the 5.8S rRNA sequence was located within the internal transcribed spacer. The known and conserved sequence of 5.8S rRNA from several organisms predicts a characteristic pattern of restriction enzyme sites for 5.8S rDNA. Internal transcribed spacer rDNA was mapped with restriction enzymes, and the characteristic pattern was found near the midpoint of the internal transcribed spacer. This places the 5.8S rRNA sequence at or near the 5' terminus of 32S pre-rRNA.

title: Multiple ribosomal RNA cleavage pathways in XXXX cells.

answer: @entity0


abstract: PURPOSE: Retroperitoneal iliac procedures can enable successful endovascular repair of @entity2 ( @entity2 ) in @entity0 who otherwise would not be anatomically eligible. The purpose of this study was to determine perioperative outcome with adjunctive retroperitoneal procedures compared with standard bilateral femoral exposure. METHODS: Between August 1997 and November 2002, 164 @entity0 underwent elective @entity2 repair at a single university medical center. Anatomic, demographic, and early postoperative outcome data gathered prospectively were analyzed. Thirty-two @entity0 (20%) underwent 38 separate adjunctive retroperitoneal procedures. Indications included small external iliac arteries (16 of 32 @entity0 ; 50%) and concomitant @entity3 that precluded fixation of the endograft limbs in the common iliac arteries (16 of 32 @entity0 ; 50%). The 38 procedures consisted of 8 iliac conduits only, 14 iliac conduits with iliofemoral bypass grafts, and 16 hypogastric revascularization procedures. Data for the study @entity0 were compared with data for 132 @entity0 who underwent @entity2 repair through femoral incisions. Primary end points were hospital length of stay, and early morbidity and mortality. RESULTS: Retroperitoneal procedures enabled an additional 14% of @entity0 with @entity2 to undergo endovascular techniques. However, there was a significantly higher proportion of @entity0 and @entity0 at high risk for anesthesia (American Society of Anesthesiologists class IV or higher) in the group who underwent retroperitoneal procedures. On average, retroperitoneal procedures were associated with 2.6-fold greater @entity1 , 82% longer procedure time, 1.5 days additional hospital stay, and 1.8-fold higher rate of perioperative complications, compared with @entity2 repair with femoral exposure alone. In contrast, early mortality was similar in the two groups. CONCLUSION: Adjunctive retroperitoneal procedures during @entity2 repair are associated with increased risk for complications and longer hospital length of stay, compared with @entity2 repair with standard femoral exposure only. They do not, however, increase early mortality, even in @entity0 at high risk, and enable a larger subset of @entity0 with @entity2 to undergo endovascular repair.

title: Morbidity with retroperitoneal procedures during XXXX repair.

answer: @entity2


abstract: BACKGROUND: @entity1 is often considered to be a significant risk factor for postoperative mortality when selecting candidates for coronary artery bypass grafting (CABG). METHODS: We included all @entity0 undergoing a first isolated CABG at the Karolinska Hospital in Stockholm, Sweden, between 1980 and 1995 (n = 6728). @entity0 were categorized on the basis of body mass index (BMI): non-overweight (BMI <25 kg/m2), overweight (25 kg/m2 < or = BMI <30 kg/m2), and @entity1 (BMI > or =30 kg/m2). Multivariate Cox regression was used to assess the risk of re-operation for @entity3 , @entity4 , and early (< or =30 days) and late (< or =5 years) mortality rates. RESULTS: The average length of follow-up was 6.5 years. There were 252 re-operations for @entity3 , 53 deep sternal wound infections, and 628 @entity2 . @entity0 who were @entity1 had a significantly lower risk of re-operation for @entity3 (risk ratio [RR], 0.32; 95% CI, 0.19-0.53), but a greater risk of @entity4 (RR, 2.66; 95% CI, 1.21-5.88) compared with @entity0 who were not overweight. However, @entity0 who were @entity1 and @entity0 who were not overweight experienced similar 30-day (RR, 0.65; 95% CI, 0.34-1.27), 1-year (RR, 0.56; 95% CI, 0.29-1.10), and 5-year mortality rates (RR, 0.91; 95% CI, 0.66-1.25). Results for @entity0 who were overweight were consistent with those of @entity0 who were @entity1 . CONCLUSION: @entity0 who are @entity1 are not at a greater risk of early and late mortality after CABG compared with @entity0 who are not overweight, although they appear to have a lower risk of re-operation for @entity3 and a greater risk of @entity4 . Therefore, obesity per se is not a contraindication for CABG.

title: XXXX and the risk of early and late mortality after coronary artery bypass graft surgery.

answer: @entity1


abstract: Clinical evidence shows that @entity2 is an independent prognostic indicator of poor @entity0 outcome. @entity2 have altered physiologic processes, including increased regions of angiogenesis, @entity1 , increased distant metastasis and altered apoptotic programs. Since @entity3 is a potent controller of gene expression, identifying @entity3 -regulated genes is a means to investigate the molecular response to @entity3 stress. Traditional experimental approaches have identified physiologic changes in @entity3 cells. Recent studies have identified @entity3 -responsive genes that may define the mechanism(s) underlying these physiologic changes. For example, the regulation of glycolytic genes by @entity3 can explain some characteristics of the Warburg effect. The converse of this logic is also true. By identifying new classes of @entity3 -regulated gene(s), we can infer the physiologic pressures that require the induction of these genes and their protein products. Furthermore, these physiologically driven @entity3 gene expression changes give us insight as to the poor outcome of @entity0 with @entity2 . Approximately 1-1.5% of the genome is transcriptionally responsive to @entity3 . However, there is significant heterogeneity in the transcriptional response to @entity3 between different cell types. Moreover, the coordinated change in the expression of families of genes supports the model of physiologic pressure leading to expression changes. Understanding the evolutionary pressure to develop a ' @entity3 response' provides a framework to investigate the biology of the @entity2 microenvironment.

title: Investigating XXXX physiology through gene expression patterns.

answer: @entity2


abstract: To describe the epidemiological and laboratory characteristics of @entity3 at a referral center in Brazil. Charts of all @entity0 referred to the Ocular Microbiology Laboratory at Federal University of S  o Paulo (UNIFESP) from July 1975 to September 2007 were retrospectively reviewed. The following data were recorded: age, gender, involved eye, use of ocular medication, previous @entity1 or surgery, contact lens wear and the results of laboratory cultures. The study included 6,804 corneal cultures. The mean age was 42.1      21.4  years. The male-to-female ratio was 1.5:1. Positive cultures were obtained in 3,309 (48.6%) cases. Of these, bacteria were isolated in 2,699 (39.7%), fungi in 364 (5.3%) and Acanthamoeba in 246 (3.6%) samples. Positive bacterial cultures were 2.7-fold more frequent in @entity0 with previous use of @entity2 (P  <  0.01), and a 30% reduction in positive bacterial cultures was observed in @entity0 with previous use of antibiotics (P  <  0.01). A total of 1,524 @entity0 (22.4%) had a past history of ocular surgery. Contact lens wearers showed a 1.7 times greater chance of having an Acanthamoeba-positive culture (P  <  0.01). Previous @entity4 was present in 1,118 (16.4%) cases and injury caused by plants showed a 3.8 times greater chance of a positive fungal culture (P  <  0.01). Bacterial organisms were identified as the most frequent agent followed by fungi and Acanthamoeba. Prescription of @entity2 and antibiotics prior to corneal scrapings may modify the laboratory test results. Previous corneal surgery, contact lens wear and @entity4 have been shown to be risk factors for @entity5 , respectively.

title: XXXX at a referral center in Brazil.

answer: @entity3


abstract: BACKGROUND: A study was undertaken to assess clinical outcome and the role of proton therapy for local control of @entity4 ( @entity4 ). METHODS: All @entity0 who received proton therapy or mixed photon-proton radiotherapy from 1983 to 2009 at the Massachusetts General Hospital were reviewed. Criteria for proton therapy were the need for high dose in the context of highly conformal radiotherapy of unresected or partially resected @entity4 , positive postoperative margins, postoperative imaging studies with @entity1 , or incomplete resection as defined by the surgeon. The primary endpoint was local control of the site treated; secondary endpoints were disease-free survival (DFS), overall survival (OS), long-term @entity2 , and prognostic factors associated with clinical outcome. RESULTS: Fifty-five @entity0 with a median age of 29 years (range, 2-76 years) were offered proton therapy. The mean dose was 68.4 gray (Gy; standard deviation, 5.4 Gy). Of the total dose, 58.2% (range, 11%-100%) was delivered with protons. Local control after 3 and 5 years was 82% and 72%, respectively. The distant failure rate was 26% after 3 and 5 years. The 5-year DFS was 65%, and the 5-year OS was 67%. The extent of surgical resection did not correlate with outcome. Risk factors for local failure were >=  2 grade disease (P < .0001) and total treatment length (P = .008). Grade 3 to 4 late @entity2 was seen in 30.1 % of @entity0 . One @entity0 died from treatment-associated @entity5 , and 1 from secondary @entity3 . CONCLUSIONS: Proton therapy to deliver high radiotherapy doses allows locally curative treatment for some @entity0 with unresectable or incompletely resected @entity4 .

title: Proton-based radiotherapy for unresectable or incompletely resected XXXX .

answer: @entity4


abstract: AIM: To determine features of intestinal microbiocenosis in @entity5 as well as biological characteristics of isolated microflora in residents of Orenburg city. MATERIALS AND METHODS: 70 @entity0 one year old and 60 adult 1 - 60 years old were examined for @entity5 . Bacteriologic identification of the large intestine's content was performed using method of serial dilutions. Isolated microorganisms were identified by routine methods. Assessment of the degree of @entity1 was conducted according to the standard guideline " @entity0 management protocol. @entity5 ". Antibiotic resistance of @entity4 species was determined by disc-diffusion method, antagonistic activity of lactobacilli--by plate culture method, and @entity6 activity--by agar bullet method. RESULTS: @entity1 were registered in more than 90% of examined subjects. For @entity0 of both age groups, stage I of @entity5 was observed most often. @entity1 were characterized by increased amount of bacteria from @entity4 genus and @entity2 -like fungi from Candida genus. It was established that antibiotic resistance was widely prevalent in isolated strains of @entity4 . At the same time representatives of normal microflora, i.e. lactobacilli, had a marked antagonistic activity against @entity4 species, @entity3 , Candida fungi and low level of @entity6 activity. CONCLUSION: Among the population of Orenburg, @entity5 was widely prevalent and characterized by predominance of @entity4 spp. and Candida spp. among opportunistic microflora. One of the rational methods of correction of compensated forms of @entity5 is stimulation of growth of normal flora including lactobacilli, which have antagonistic activity.

title: [Features of microbiocenosis of the large intestine in XXXX ].

answer: @entity1


abstract: OBJECTIVE: Transapical @entity1 (TAVI) is a new method that might reduce the surgical risk of conventional surgical aortic valve replacement in very high-risk @entity0 . Increased downstream microembolization is expected in transapical @entity1 . However, whether it usually occurs, how often, and its clinical relevance are not known. We report the results of ultrasound microembolic signal detection in the middle cerebral artery during the procedure. METHODS: Fifty @entity0 (mean age: 80    5 years; mean EuroSCORE: 36    13 %) underwent transapical @entity1 . Intraoperative transcranial Doppler (TCD) sound examination of both middle cerebral arteries (MCA) was used to identify high-intensity transient signals (HITS) and @entity3 ( @entity3 ) during seven phases of the procedure. Pre- and postoperative computed tomography of the brain and clinical neurological examinations were performed preoperatively and daily during the first postoperative week. RESULTS: During the procedure, HITS [right MCA: 435    922 (range 9-5765); left MCA: 471    996 (range 24-6432)] and @entity3 [right MCA: 78    172 (range 1-955); left MCA: 62    190 (range 2-1553)] were detected in all @entity0 . Most of the @entity3 were recorded during valvuloplasty [right MCA: 3    5.6 (range 0-31); left MCA: 2    4.9 (range 0-30)] and positioning of the prosthetic valve in the aortic position [right MCA: 6    5 (range 0-22); left MCA: 2    6.9 (range 0-38)]. Postoperatively, there were no clinical signs of new @entity2 . CONCLUSIONS: Cerebral microemboli were detected by intraoperative transcranial Doppler sound examinations in all @entity0 during transapical @entity1 . Most of the signals were detected during balloon valvuloplasty and delivery of the prosthetic valve.

title: Transcranial Doppler sound detection of cerebral microembolism during transapical XXXX .

answer: @entity1


abstract: AIM: To estimate the association between baby swimming and recurrent @entity4 and @entity6 media in the first year of life in @entity0 of parents without and with atopy. METHODS: Norwegian schoolchildren (n = 2862) was enrolled in a cross-sectional study of @entity2 and @entity3 using the questionnaire of the International Study of @entity3 in Childhood (ISAAC). The outcomes were parental retrospective report of recurrent @entity4 and @entity6 media diagnosed by a physician in the first year of life. The exposure was baby swimming during the same period. Parental atopy reflects a history of maternal or paternal @entity2 , @entity5 or @entity1 . RESULTS: The prevalence of recurrent @entity4 was higher (12.3%) among @entity0 who took part in baby swimming than among those who did not (7.5%). The prevalence of recurrent @entity4 during the first year of life was 5.6% and 10.5%, respectively, in @entity0 of parents without and with atopy, whereas the prevalence of baby swimming was 5.6% and 5.1%, respectively, in the two groups. Stratified analysis using parental atopy as strata showed that the increased risk of recurrent @entity4 was only present among @entity0 of parents with atopy [adjusted odds ratio (aOR) 2.08, 95% confidence interval (95% CI) 1.08-4.031. A similar trend was present for @entity6 media (aOR 1.77, 95% CI 0.96-3.25). CONCLUSION: The results of this study suggest that baby swimming and @entity0 respiratory health may be linked. The findings need to be examined in a longitudinal study.

title: Baby swimming increases the risk of recurrent @entity4 and XXXX media.

answer: @entity6


abstract: AIM: To estimate the association between baby swimming and recurrent @entity4 and @entity6 media in the first year of life in @entity0 of parents without and with atopy. METHODS: Norwegian schoolchildren (n = 2862) was enrolled in a cross-sectional study of @entity2 and @entity3 using the questionnaire of the International Study of @entity3 in Childhood (ISAAC). The outcomes were parental retrospective report of recurrent @entity4 and @entity6 media diagnosed by a physician in the first year of life. The exposure was baby swimming during the same period. Parental atopy reflects a history of maternal or paternal @entity2 , @entity5 or @entity1 . RESULTS: The prevalence of recurrent @entity4 was higher (12.3%) among @entity0 who took part in baby swimming than among those who did not (7.5%). The prevalence of recurrent @entity4 during the first year of life was 5.6% and 10.5%, respectively, in @entity0 of parents without and with atopy, whereas the prevalence of baby swimming was 5.6% and 5.1%, respectively, in the two groups. Stratified analysis using parental atopy as strata showed that the increased risk of recurrent @entity4 was only present among @entity0 of parents with atopy [adjusted odds ratio (aOR) 2.08, 95% confidence interval (95% CI) 1.08-4.031. A similar trend was present for @entity6 media (aOR 1.77, 95% CI 0.96-3.25). CONCLUSION: The results of this study suggest that baby swimming and @entity0 respiratory health may be linked. The findings need to be examined in a longitudinal study.

title: Baby swimming increases the risk of recurrent XXXX and @entity6 media.

answer: @entity4


abstract: OBJECTIVE: There has been at least 40 years of active research on screening for @entity1 and distress in primary care. Both successes and failures have been documented. The purpose of this focussed narrative review was to summarise this research and present the key lessons for clinicians and researchers working in psychosocial oncology. METHODS: We searched for studies assessing the utility of screening in primary care in seven electronic bibliographic databases (CENTRAL, CINAHL, Embase, @entity2 , Medline, PsycINFO, Web of Knowledge) from inception to December 2010. Results were reviewed and summarised into key areas. RESULTS: We found that research could be distilled into the following key learning points. (1) Primary care is an important partner in psychosocial care. (2) Both over and under detection are problematic. (3) Barriers to identification involve @entity0 and clinician factors. (4) Acceptability of screening is critical to implementation. (5) Underserved groups need special attention in screening. (6) @entity0 -clinician trust is an important modifiable variable. (7) Greater contact influences detection. (8) Clinician confidence/skills influence screening success and subsequent action. (9) Training may improve confidence but effects upon long-term outcomes are modest. (10) Screening is generally ineffective without aftercare. CONCLUSIONS: Primary care has shown largely what does not work in relation to screening. Namely relying on clinicians' unassisted judgement without infrastructural support, using over-complex scales with low acceptability, looking for @entity1 alone, using screening without linked treatment, treating in the absence of follow-up and failing to engage @entity0 in their own care. These pitfalls can and should be avoided in psychosocial oncology.

title: Screening for distress and XXXX in cancer settings: 10 lessons from 40 years of primary-care research.

answer: @entity1


abstract: Blood management is an evolving field of reducing transfusions of allogeneic blood by maximizing multi-modality therapy to optimize red cell mass, reduce red cell loss, and harvest red cells that would have otherwise been discarded. These techniques are highly dependent upon teams working together. The programs are not just focused upon red cells but also on coagulation therapy. @entity3 is at times a difficult complex pathologic conundrum. In cardiac surgery the complexity is added to because of the inflammatory effects of anticoagulation, air/blood interfaces, and @entity1 . @entity0 respond variably due to their own genetic and environmental factors. There can be a rational approach, thereby avoiding panic (a normal fear response) if the clinician utilizes not only the available laboratory technologies existing today but also follows published algorithms for treatment. These technologies with their coexisting algorithms have been widely shown to decrease blood usage, yet not to decrease @entity2 . That finding suggests that therapy without such guidance wastes expensive pro-coagulant blood products and produces no advantage (a decrease in @entity2 ). When a therapy produces no advantage all that it leaves the @entity0 with is the side effects or adverse outcomes. Adverse outcomes from coagulation products are real and sobering.

title: Blood management-issues: the panic of XXXX --is there a rational approach?

answer: @entity2


abstract: The purpose of this prospective phase II trial was to investigate the safety and efficacy of a modified baseline BEACOPP ( @entity10 , @entity13 , @entity4 , @entity5 , @entity12 , @entity14 , and @entity3 ) regimen in the treatment of intermediate and advanced stage @entity6 ( @entity6 ). From October 1997 to November 2001, 51 consecutive, previously untreated @entity0 with stage IIA (bulky), IIB, III, and IV disease were treated with a modified baseline BEACOPP regimen with the @entity13 administered i.v. on day 1 and orally at a dose of 100 mg/m2, on days 2 and 3. Each @entity0 was scheduled to receive eight courses of BEACOPP with consolidation radiotherapy to bulky (> or =5 cm) or @entity1 . There were 25 males and 26 females with a median age of 32 yr (16-65 yr); 80.3% of the @entity0 had @entity16 @entity6 , 41% had bulky disease (> or =5 cm), 10 were in stage IIA (bulky > or =10 cm), 15 in stage IIB, 19 in stage III, and seven in stage IV. Thirty-seven @entity0 (72.5%) achieved a complete response and 17.6% partial response. No significant difference in overall response rate was observed between @entity0 with: (i) 0-2 vs. > or =3 negative prognostic factors, (ii) in stage II vs. stages III/IV, LDH level, and bulky disease. With a median follow up period of 39.5 months, actuarial 3-yr survival rate is 82% and time to progression rate 72.5%. Treatment with this combination was well tolerated. Grades 3 and 4 @entity9 and @entity8 occured in 26% and 28% of the @entity0 , respectively, whereas in 16.3% of the @entity0 infection was observed. Support with @entity7 was given to 59% of the @entity0 . No case of secondary @entity15 / @entity11 has been observed. The results of the present study demonstrate that the modified baseline BEACOPP regimen with radiotherapy used in our @entity0 was well tolerated and effective therapy for intermediate and advanced stage @entity6 . Further follow up time is required to evaluate long-term @entity2 .

title: Treatment of intermediate and advanced stage XXXX with modified baseline BEACOPP regimen: a Hellenic Co-operative Oncology Group Study.

answer: @entity6


abstract: The manual of the World Health Organization defines leucocytospermia as the presence of >1 x 10(6) white blood cells per ml semen. Most authors consider leucocytospermia to be a consequence of inflammation due to @entity4 . However, the efficacy of antibiotic therapy was not unequivocally demonstrated until now. We started a prospective, randomized, controlled study in 36 @entity0 , who consulted our department for @entity1 with leucocytospermia. None of the @entity0 reported any symptoms of @entity2 . The @entity0 were assigned randomly to two groups: group 1 received 250 mg @entity3 once a day over 10 days, @entity0 of group 2 received no therapy. Semen analysis was repeated 2 weeks later. After administration of @entity3 , a mean decrease of leucocyte count of 45.8 +/- 72.2% compared with a decrease of only 3 +/- 109.2% in the untreated group was observed. However, this difference is not statistically significant. There were no significant differences between the two groups with respect to leucocyte count, sperm count and sperm cell after treatment. We conclude from our study that antibiotic therapy does not provide benefit for treatment of @entity5 .

title: Treatment with @entity3 does not resolve XXXX --a randomized controlled study.

answer: @entity5


abstract: The manual of the World Health Organization defines leucocytospermia as the presence of >1 x 10(6) white blood cells per ml semen. Most authors consider leucocytospermia to be a consequence of inflammation due to @entity4 . However, the efficacy of antibiotic therapy was not unequivocally demonstrated until now. We started a prospective, randomized, controlled study in 36 @entity0 , who consulted our department for @entity1 with leucocytospermia. None of the @entity0 reported any symptoms of @entity2 . The @entity0 were assigned randomly to two groups: group 1 received 250 mg @entity3 once a day over 10 days, @entity0 of group 2 received no therapy. Semen analysis was repeated 2 weeks later. After administration of @entity3 , a mean decrease of leucocyte count of 45.8 +/- 72.2% compared with a decrease of only 3 +/- 109.2% in the untreated group was observed. However, this difference is not statistically significant. There were no significant differences between the two groups with respect to leucocyte count, sperm count and sperm cell after treatment. We conclude from our study that antibiotic therapy does not provide benefit for treatment of @entity5 .

title: Treatment with XXXX does not resolve @entity5 --a randomized controlled study.

answer: @entity3


abstract: OBJECTIVE: Our understanding of the neurobiology of @entity2 , although not complete, has advanced significantly with the development and application of genetic, neuroimaging and neurochemical approaches. METHOD: The neuroanatomical basis of @entity2 is reviewed with particular focus on the amygdala and the temporal and prefrontal cortex. The functional anatomical correlates of @entity2 such as @entity9 , @entity10 and @entity6 are also discussed. RESULTS: Functional neuroimaging studies in @entity0 with @entity2 have shown neurophysiological abnormalities during symptom provocation tests, implicating the limbic, paralimbic and sensory association regions. The involvement of neurotransmitters such as @entity5 and @entity7 in @entity3 is well established. Antidepressants that affect these neurotransmitter systems have also been shown to be useful in the treatment and management of @entity0 with @entity2 . The role of @entity5 and @entity7 in the pathophysiology of @entity2 is reviewed. In addition, the involvement of the stress hormone corticotropin-releasing hormone, the peptide @entity11 and the @entity4 transmitter @entity8 in @entity2 is reviewed. CONCLUSION: The inconsistency in the results of biologic investigations of @entity2 highlights the importance of addressing the neurobiologic heterogeneity inherent within criteria-based, @entity1 diagnoses. Understanding of this heterogeneity will be facilitated by the continued development and application of genetic, neuroimaging and neurochemical approaches that can refine @entity2 phenotypes and elucidate the genotypes associated with these disorders. Application of these experimental approaches will also facilitate research aimed at clarifying the mechanisms of anti- @entity2 therapies.

title: Neuroanatomical circuits modulating fear and XXXX .

answer: @entity1


abstract: INTRODUCTION: Separating nonisthmus-dependent @entity4 ( @entity4 ) from "organized" @entity3 ( @entity3 ), or isthmus-dependent @entity4 , may be difficult using ECG characteristics alone. We hypothesized that temporal and spatial phase analysis of ECG atrial waveforms could effectively separate these rhythms by quantifying subtle variations in ECG atrial activation during @entity5 ( @entity5 ). METHODS AND RESULTS: We studied 52 @entity0 at electrophysiologic study (EPS) who demonstrated isthmus-dependent (n = 15) and nonisthmus-dependent (n = 9) @entity4 , @entity1 (n = 6), AV nodal reentry (n = 9), orthodromic reciprocating @entity1 (n = 6), and @entity3 (n = 7). Atrial activity was represented as a series of correlations of an atrial template to successive time samples of the @entity2 ECG. Spatial phase was analyzed as a reproducible relationship of this atrial activity between leads over time; temporal regularity was measured from power spectra. Spatial phase was maintained (coherent) in lead planes V5/aVF (XY), V5/V1 (XZ), and aVF/V1 (YZ) in 15 of 15 cases of isthmus-dependent @entity4 , but in only 1 of 9 cases of nonisthmus-dependent @entity4 (P < 0.01; chi2). Temporally, all cases of @entity4 showed one dominant peak on correlation spectra (magnitude >6 dB), suggesting one activation wavefront, although this was smeared in nonisthmus-dependent cases. In contrast, @entity3 showed inconsistent spatial phase in all planes and broad band spectra, consistent with multiple and/or variable activation paths. All other SVTs showed spatial coherence and one dominant spectral peak. CONCLUSION: Coherence of temporal and spatial phase is a powerful approach to measure the spatial organization of intracardiac activation from the ECG that reveals a spectrum from @entity5 to isthmus-dependent and nonisthmus-dependent @entity4 , to @entity3 .

title: Quantifying intracardiac organization of XXXX using temporospatial phase of the electrocardiogram.

answer: @entity2


abstract: The technique of the Turnbull-Cutait pullthrough procedure as performed at the Cleveland Clinic for @entity3 and other conditions is described. The results in 127 @entity0 are reported. Eighty-four @entity0 were operated upon for @entity3 and 47 for miscellaneous benign conditions. The average distance of @entity1 from the anal margin was 7.6 cm. The average margin of resection was 4.1 cm. The overall operative mortality was 1.2% in the @entity1 group. @entity2 occurred in 1.2% of the @entity1 @entity0 , and minor @entity4 occurred in 7.1%. The five-year survival in Dukes' A, B and C @entity3 was 100%, 57% and 53%, respectively. The incidence of pelvic recurrence of the @entity1 at 6% was within acceptable limits. The quality of bowel function following the pullthrough procedure is discussed. It is concluded that this pullthrough procedure has a significant role in the management of @entity3 and other conditions.

title: The Turnbull-Cutait pullthrough procedure for certain XXXX of the rectum and Hirschsprung disease.

answer: @entity1


abstract: @entity3 ( @entity3 ) and @entity2 are routinely used to inhibit disease activity in @entity1 , but their mechanisms of action are incompletely understood. Individual treatment responses vary and candidate molecular markers that predict them have yet to be established. Why some @entity0 respond poorly to a certain treatment while others respond well is addressed by the pharmacogenomic approach, which postulates that the molecular response to treatment correlates with the clinical effects, and thus seeks biological markers to estimate prognosis, guide therapy, comprehend the drugs' mechanisms of action and offer insights into disease pathogenesis. A poor clinical response can be owing to genetic variants in drug receptors or signaling components, or the appearance of neutralizing antibodies that interfere with the drug's binding efficacy. Independently, such mechanisms could lead to inadequate, that is to say unchanged, molecular responses, or exceedingly increased or decreased changes. By means of DNA microarray studies, various research groups endeavour to establish a clinically relevant relationship between the biological response to these drugs and treatment effects. Molecular profiles obtained in this way differ in the pattern and number of modulated genes, suggesting the existence of an individual 'drug-response fingerprint'. To further unravel the underlying regulatory interaction structure of the genes responsive to these immunotherapies represents a daunting but inevitable task. In this article, we focus on longitudinal ex vivo transcriptomic studies in @entity1 and its therapy. We will discuss recurrently reported biomarker candidates, emphasizing those of immunologically meaning, and review studies with network module outputs.

title: Sieving treatment biomarkers from blood gene-expression profiles: a pharmacogenomic update on two types of XXXX therapy.

answer: @entity1


abstract: Radiation is used in the study of neurogenesis in the adult @entity2 both as a model for @entity0 undergoing radiation therapy for CNS @entity1 and as a tool to interrupt neurogenesis. We describe the use of a dedicated CT-guided precision device to irradiate specific sub-regions of the adult @entity2 brain. Improved CT visualization was accomplished with intrathecal injection of iodinated contrast agent, which enhances the lateral ventricles. T2-weighted MRI images were also used for target localization. Visualization of delivered beams (10 Gy) in tissue was accomplished with immunohistochemical staining for the protein y- @entity3 , a marker of DNA double-strand breaks. y- @entity3 stains showed that the lateral ventricle wall could be targeted with an accuracy of 0.19 mm (n = 10). In the hippocampus, y- @entity3 staining showed that the dentate gyrus can be irradiated unilaterally with a localized arc treatment. This resulted in a significant decrease of proliferative neural progenitor cells as measured by Ki-67 staining (P < 0.001) while leaving the contralateral side intact. Two months after localized irradiation, neurogenesis was significantly inhibited in the irradiated region as seen with @entity5 / @entity4 double labeling (P < 0.001). Localized radiation in the rodent brain is a promising new tool for the study of neurogenesis.

title: Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult XXXX brain.

answer: @entity2


abstract: BACKGROUND: Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for @entity2 older adults is controversial. METHODS: In this 1-year, randomized, controlled trial, we evaluated the independent and combined effects of weight loss and exercise in 107 adults who were 65 years of age or older and @entity2 . @entity0 were randomly assigned to a control group, a weight-management (diet) group, an exercise group, or a weight-management-plus-exercise (diet-exercise) group. The primary outcome was the change in score on the modified Physical Performance Test. Secondary outcomes included other measures of frailty, body composition, bone mineral density, specific physical functions, and quality of life. RESULTS: A total of 93 @entity0 (87%) completed the study. In the intention-to-treat analysis, the score on the Physical Performance Test, in which higher scores indicate better physical status, increased more in the diet-exercise group than in the diet group or the exercise group (increases from baseline of 21% vs. 12% and 15%, respectively); the scores in all three of those groups increased more than the scores in the control group (in which the score increased by 1%) (P<0.001 for the between-group differences). Moreover, the peak @entity1 consumption improved more in the diet-exercise group than in the diet group or the exercise group (increases of 17% vs. 10% and 8%, respectively; P<0.001); the score on the Functional Status Questionnaire, in which higher scores indicate better physical function, increased more in the diet-exercise group than in the diet group (increase of 10% vs. 4%, P<0.001). Body weight decreased by 10% in the diet group and by 9% in the diet-exercise group, but did not decrease in the exercise group or the control group (P<0.001). Lean body mass and bone mineral density at the hip decreased less in the diet-exercise group than in the diet group (reductions of 3% and 1%, respectively, in the diet-exercise group vs. reductions of 5% and 3%, respectively, in the diet group; P<0.05 for both comparisons). Strength, balance, and gait improved consistently in the diet-exercise group (P<0.05 for all comparisons). Adverse events included a small number of exercise-associated @entity3 . CONCLUSIONS: These findings suggest that a combination of weight loss and exercise provides greater improvement in physical function than either intervention alone. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT00146107.).

title: Weight loss, exercise, or both and physical function in XXXX older adults.

answer: @entity2


abstract: OBJECTIVE: To assess background pre-pandemic cross-reacting antibodies to the pandemic (H1N1) 2009 virus in older populations in Australia. DESIGN, SETTING AND @entity0 : Data were opportunistically generated from three cross-sectional pre-pandemic studies involving @entity0 aged 60 years or older: a 3-year (2006-2008) study of @entity1 outbreaks in aged care facilities (ACFs) in Sydney; an investigation of a respiratory virus outbreak in an @entity2 in rural New South Wales in June 2009; and a non- @entity1 serosurvey undertaken in NSW in 2007 and 2008. MAIN OUTCOME MEASURE: Prevalence of pandemic (H1N1) 2009 haemagglutination inhibition (HAI) antibody titres >=  1:40 (putative protective level) in pre-pandemic sera. RESULTS: In total, 259 serum samples from individuals aged 60 years or older (range, 60-101 years) were tested. More than half of the individuals tested were @entity0 (151/259; 58.3%). About a third of individuals (37.5%) had cross-reacting HAI antibody titres >=  1:40. The prevalence of cross-reacting antibodies was highest in the oldest age groups (>=  85 years), with more than 60% of these @entity0 having HAI antibody titres >=  1:40. The proportion of subjects with HAI antibody titres >=  1:40 decreased significantly and successively in younger groups to only 12% of those aged 60-64 years. CONCLUSIONS: Our study suggests a pre-existing @entity1 A antibody reserve in most of the oldest group of @entity0 that was cross-reactive to the new pandemic (H1N1) 2009 virus; this is likely to be lifelong and to have provided them with clinical protection against the first wave of the pandemic. Pandemic @entity1 control measures need to focus more on younger adults naive to the pandemic virus and at increased risk of severe disease.

title: Cross-reacting antibodies against the pandemic (H1N1) 2009 XXXX virus in older Australians.

answer: @entity1


abstract: Information on the clinical spectrum and management of @entity5 after kidney transplantation is limited. From April 2007 to April 2010, 17 kidney transplant recipients were diagnosed with @entity5 . The median time to @entity1 was 5 (range, 2-300) weeks after transplantation. Of the 17 @entity0 , 13 (76.5%) presented early, within 3 months posttransplant, and four (23.5%) presented late, more than 3 months after transplant. Besides urinary tract, involvement of other organs was common (63.6%) among @entity0 with @entity5 . Despite reduction of immunosuppression, six @entity0 subsequently had a rise in the level of blood viral load, mostly within a week after diagnosis. However, only three (27.3%) @entity0 with @entity1 developed disease progression. Compared to the late @entity1 group, @entity0 with @entity1 had significantly lower absolute lymphocyte counts at week 1 (p = 0.01) and 3 (p = 0.002) after diagnosis. Four @entity0 received intravenous @entity4 . At 6-month follow-up, 10 (90.9%) @entity0 had reversible @entity2 . Only one (5.7%) died from @entity3 . @entity5 is a significant complication following kidney transplantation. Early case recognition with reduction of immunosuppression is critical. Serial blood adenovirus viral loads and assessment of lymphocyte recovery are also useful in monitoring the course of @entity1 .

title: XXXX after kidney transplantation: course of @entity1 and outcome in relation to blood viral load and immune recovery.

answer: @entity5


abstract: Information on the clinical spectrum and management of @entity5 after kidney transplantation is limited. From April 2007 to April 2010, 17 kidney transplant recipients were diagnosed with @entity5 . The median time to @entity1 was 5 (range, 2-300) weeks after transplantation. Of the 17 @entity0 , 13 (76.5%) presented early, within 3 months posttransplant, and four (23.5%) presented late, more than 3 months after transplant. Besides urinary tract, involvement of other organs was common (63.6%) among @entity0 with @entity5 . Despite reduction of immunosuppression, six @entity0 subsequently had a rise in the level of blood viral load, mostly within a week after diagnosis. However, only three (27.3%) @entity0 with @entity1 developed disease progression. Compared to the late @entity1 group, @entity0 with @entity1 had significantly lower absolute lymphocyte counts at week 1 (p = 0.01) and 3 (p = 0.002) after diagnosis. Four @entity0 received intravenous @entity4 . At 6-month follow-up, 10 (90.9%) @entity0 had reversible @entity2 . Only one (5.7%) died from @entity3 . @entity5 is a significant complication following kidney transplantation. Early case recognition with reduction of immunosuppression is critical. Serial blood adenovirus viral loads and assessment of lymphocyte recovery are also useful in monitoring the course of @entity1 .

title: @entity5 after kidney transplantation: course of XXXX and outcome in relation to blood viral load and immune recovery.

answer: @entity1


abstract: BACKGROUND: Although 2-20% of @entity0 @entity1 develop a @entity0 ( @entity0 ), prognosis after @entity0 is still debated. Using a unique @entity1 cohort, we have investigated whether time interval to second @entity0 ( @entity4 ) and mode of detection are associated to prognosis. METHODS: Information on @entity1 -, @entity3 -, treatment-characteristics, and outcome was abstracted from @entity1 ' individual charts for all @entity1 diagnosed with metachronous @entity0 in the Southern Healthcare Region of Sweden from 1977-2007. Distant disease-free survival (DDFS) and risk of distant @entity2 were primary endpoints. RESULTS: The cohort included 723 @entity1 with metachronous @entity0 as @entity0 event. @entity1 with less than three years to @entity4 had a significantly impaired DDFS (p = 0.01), and in sub-group analysis, this effect was seen primarily in @entity1 aged <50. By logistic regression analysis, @entity1 diagnosed with @entity4 within routine follow-up examinations had a significantly lower risk of developing @entity2 compared to those who were symptomatic at diagnosis (p < 0.0001). Chemotherapy given after breast BC1 was a negative prognostic factor for DDFS, whereas endocrine treatment and radiotherapy given after @entity4 improved DDFS. CONCLUSIONS: In a large cohort of @entity1 with @entity0 , we found the time interval to @entity4 to be a strong prognostic factor for DDFS in young @entity1 and mode of detection to be related to risk of distant @entity2 . Future studies of @entity3 biology of @entity4 in relation to prognostic factors found in the present study can hopefully provide biological explanations to these findings.

title: Prediction of outcome after diagnosis of metachronous XXXX .

answer: @entity0


abstract: OBJECTIVES: Despite serious safety concerns, prescription rates of antipsychotics for the treatment of the behavioral and psychological symptoms of @entity3 remain high, especially in nursing homes. This high prevalence of antipsychotic use cannot be explained by the modest success rate reported in the literature. In this study, we aim at clarifying the reasons for prescribing an antipsychotic drug in behavioral and psychological symptoms of @entity3 and look at the role of nurses and family caregivers in the decision-making process that precedes the prescription of an antipsychotic drug. DESIGN: Questionnaire used in a one-on-one interview with elderly care physicians, nurses, and family caregivers. SETTING: We conducted a survey in 23 nursing homes in the Netherlands. METHOD: On each @entity3 ward, the physician selected 1 or 2 @entity0 who started antipsychotics most recently. An interviewer then held a structured questionnaire with the physician, the nurse, and the first relative of the @entity0 . The first part of the interview consisted of questions about the general ideas of the physicians and the second part consisted of case-related questions to physicians, nurses, and family caregivers. RESULTS: Physicians, nurses, and family caregivers generally consider the possible benefits of antipsychotics to outweigh the risk of side effects. The main reasons to start therapy are agitation and @entity2 . Physicians felt pressured by nurses to prescribe in 17% of cases. Physicians felt supported by the guideline of the Dutch Association of Elderly Care Physicians. The estimated average success rate in the discussed cases (the @entity0 is expected to improve on the @entity2 ) among physicians was 50%, nurses reported 53%, and relatives 55%. The most frequently expected adverse reactions were increased fall risk, sedation, and @entity4 . Nurses expected @entity1 . The family felt insufficiently informed about the side effects in 44% of the cases. CONCLUSION: The interviewed nursing home physicians and nurses expect almost half of their @entity0 with @entity3 and @entity2 to benefit from antipsychotic therapy. Serious side effects were expected to occur only sporadically. These expectations may contribute to the high rate of antipsychotic use among these @entity0 .

title: Reasons to prescribe antipsychotics for the behavioral symptoms of XXXX : a survey in Dutch nursing homes among physicians, nurses, and family caregivers.

answer: @entity3


abstract: OBJECTIVE: To evaluate somatosensory and auditory primary cortices using somatosensory evoked potentials (SEPs) and middle latency auditory evoked potentials (MLAEPs) in the prognosis of @entity6 in @entity4 @entity0 . METHODS: SEPs and MLAEPs were recorded in 131 severe @entity4 @entity0 . Latencies and amplitudes were measured. @entity4 had been caused by transient @entity5 (n=49), @entity2 (n=22), @entity1 (n=45), complications of neurosurgery (n=12) and @entity3 (n=3). One month after the onset of @entity4 @entity0 were classified as awake, still @entity4 or dead. Three months after (M3), they were classified into one of the 5 categories of the Glasgow outcome scale (GOS). RESULTS: At M3, 41.2% were dead, 47.3% were conscious (GOS 3-5) and 11.5% had not recovered consciousness. None of the @entity0 in whom somatosensory N20 and auditory Pa were absent did @entity6 and in the post-anoxic group, reduced cortical amplitude too was always associated with bad outcome. Conversely, N20 and Pa were present, respectively, in 33/69 and 34/69 @entity0 who did not recover. CONCLUSIONS: The prognostic value of SEPs and MLAEPs in @entity4 @entity0 depends on the cause of @entity4 . Measurement of response amplitudes is informative. Abolition of cortical SEPs and/or cortical MLAEPs precludes post-anoxic @entity4 @entity0 from returning to consciousness (100% specificity). In any case, the presence of short latency cortical somatosensory or auditory components is not a guarantee for @entity6 . Late components should then be recorded.

title: The prognostic value of evoked responses from primary somatosensory and auditory cortex in comatose XXXX .

answer: @entity0


abstract: OBJECTIVE: @entity7 ( @entity7 ) is a rapidly progressive @entity5 with typical clinical findings of @entity4 , @entity2 , and @entity6 and characteristic electroencephalographic (EEG) findings of bilateral synchronous periodic sharp waves. Advances in neuroimaging capabilities with diffusion-weighted and fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) techniques have shown promise in the non-invasive diagnosis of @entity7 . This series illustrates the correlation between the lateralized and focal clinical, EEG, and MRI FLAIR sequence abnormalities in 8 @entity0 (7 @entity0 and one @entity0 55-73 years old) with @entity7 . METHODS: A case series of 8 @entity0 , evaluated at Mayo Clinic, who had a history of rapidly progressive lateralized or focal @entity1 and laboratory findings consistent with @entity7 between 1996 and 1999 were identified. EEG, MRI of the head with FLAIR sequence, and cerebrospinal fluid studies were performed in all @entity0 . RESULTS: Mean time to death from symptom onset was 4 months. Symptoms were lateralized to the left hemisphere in 5 @entity0 and to the right hemisphere in two. One @entity0 showed bilateral occipital lobe involvement. In all @entity0 , the EEG showed lateralized or focal periodic sharp waves that colocalized with clinical @entity3 . FLAIR MRI images revealed increased signal in the cortical ribbon and deep gray matter corresponding to the lateralized clinical and EEG findings in 7 @entity0 . The other @entity0 had bilateral occipital increased signal on FLAIR MRI. CONCLUSIONS: @entity7 may present with lateralized or focal cortical syndromes with colocalizing EEG and MRI findings. With the appropriate clinical history and laboratory evaluation, the corresponding areas of increased signal on FLAIR MRI provide supportive evidence of the disease. SIGNIFICANCE: @entity7 can sometimes present with more focal or lateralized clinical findings, and the colocalizing EEG and MRI findings can help make or confirm the diagnosis of @entity7 .

title: Lateralized and focal clinical, EEG, and FLAIR MRI abnormalities in XXXX .

answer: @entity7


abstract: @entity2 ( @entity2 ) is a protein family that is found only in the Eukaryotes. They are used for the interfacing of cell to the outside world and are involved in many physiological processes. Their role in drug development is evident. Hence, the prediction of GPCRs is very much demanding. Because of the unavailability of 3D structures of most of the GPCRs; the statistical and machine learning based prediction of GPCRs is much demanding. The GPCRs are classified into family, sub family and sub-sub family levels in the proposed approach. We have extracted features using the hybrid combination of Pseudo @entity0 , Fast Fourier Transform and Split @entity0 techniques. The overall feature vector is then reduced using Principle component analysis. Mostly, GPCRs are composed of two or more sub units. The arrangement and number of sub units forming a @entity2 are referred to as quaternary structure. The functions of GPCRs are closely related to their quaternary structure. The classification in the present research is performed using @entity1 ( @entity1 ) measure, which can efficiently analyze the numerical relation between various components of GPCRs. The @entity1 measure based classification has shown remarkable improvement in predicting GPCRs.

title: Prediction of GPCRs with pseudo XXXX composition: employing composite features and @entity1 based classification.

answer: @entity0


abstract: @entity2 ( @entity2 ) is a protein family that is found only in the Eukaryotes. They are used for the interfacing of cell to the outside world and are involved in many physiological processes. Their role in drug development is evident. Hence, the prediction of GPCRs is very much demanding. Because of the unavailability of 3D structures of most of the GPCRs; the statistical and machine learning based prediction of GPCRs is much demanding. The GPCRs are classified into family, sub family and sub-sub family levels in the proposed approach. We have extracted features using the hybrid combination of Pseudo @entity0 , Fast Fourier Transform and Split @entity0 techniques. The overall feature vector is then reduced using Principle component analysis. Mostly, GPCRs are composed of two or more sub units. The arrangement and number of sub units forming a @entity2 are referred to as quaternary structure. The functions of GPCRs are closely related to their quaternary structure. The classification in the present research is performed using @entity1 ( @entity1 ) measure, which can efficiently analyze the numerical relation between various components of GPCRs. The @entity1 measure based classification has shown remarkable improvement in predicting GPCRs.

title: Prediction of GPCRs with pseudo @entity0 composition: employing composite features and XXXX based classification.

answer: @entity1


abstract: PROBLEM    In this baseline study, our aim is to show the relationship of parameters and gonad hormones in menopausal and postmenopausal @entity0 . METHOD    Blood samples were taken from menopausal and postmenopausal @entity0 (12-14 months and >= 10 years, respectfully, since their last menstruation). Adolescents aged 13.7    0.7 were used as controls. @entity7 were measured by ELISA and percentages of @entity4 , @entity1 , @entity2 , CD3, @entity3 , @entity5 , @entity6 and HLA-DR were measured by flow cytometry. RESULTS Both groups showed an increase in the percentage of CD3, @entity1 and @entity2 . Levels of @entity3 were significantly lower in the postmenopausal group. However, changes in immunologic parameters during menopause were less marked than the hormonal changes observed in these groups. Most of the correlations LH       CD3 (-ve), LH       @entity6 (-ve) and E2       @entity3 (+ve) suggesting how menopausal @entity0 with particularly high LH or low E2 levels may be affected. Only CD3 and HLA-DR correlated with the hormonal changes in the postmenopausal group. @entity5 levels were high in the menopausal group and low in the postmenopausal group; however, no correlation was observed. DISCUSSION    Menopause is characterized by increased levels of @entity5 , which has critical immune-modulatory effects. These changes may be related to the overall hormonal change process observed during menopause.

title: Relationship between lymphocytes, XXXX and the hormones E2, LH, PRG and FSH in menopausal and postmenopausal @entity0 .

answer: @entity5


abstract: PROBLEM    In this baseline study, our aim is to show the relationship of parameters and gonad hormones in menopausal and postmenopausal @entity0 . METHOD    Blood samples were taken from menopausal and postmenopausal @entity0 (12-14 months and >= 10 years, respectfully, since their last menstruation). Adolescents aged 13.7    0.7 were used as controls. @entity7 were measured by ELISA and percentages of @entity4 , @entity1 , @entity2 , CD3, @entity3 , @entity5 , @entity6 and HLA-DR were measured by flow cytometry. RESULTS Both groups showed an increase in the percentage of CD3, @entity1 and @entity2 . Levels of @entity3 were significantly lower in the postmenopausal group. However, changes in immunologic parameters during menopause were less marked than the hormonal changes observed in these groups. Most of the correlations LH       CD3 (-ve), LH       @entity6 (-ve) and E2       @entity3 (+ve) suggesting how menopausal @entity0 with particularly high LH or low E2 levels may be affected. Only CD3 and HLA-DR correlated with the hormonal changes in the postmenopausal group. @entity5 levels were high in the menopausal group and low in the postmenopausal group; however, no correlation was observed. DISCUSSION    Menopause is characterized by increased levels of @entity5 , which has critical immune-modulatory effects. These changes may be related to the overall hormonal change process observed during menopause.

title: Relationship between lymphocytes, @entity5 and the hormones E2, LH, PRG and FSH in menopausal and postmenopausal XXXX .

answer: @entity0


abstract: As the @entity6 shortly after death, a variety of gases and volatile organic compounds (VOCs) constantly emanate. Ethical and practical reasons limit the use of @entity0 corpses in controlled, time-dependent, intervening experiments for monitoring the chemistry of body decay. Therefore the utilization of @entity8 carcasses serves as a potential surrogate to @entity0 models. The aim of this work was to study buried body decay in conditions of entrapment in collapsed buildings. Six @entity15 were used to study carcass decay. They were enclosed in plastic body bags after being partially buried with rubbles, resembling entrapment in collapsed buildings. Three experimental cycles were performed, employing two @entity8 carcasses in each cycle; VOCs and inorganic gases were measured daily, along with daily visible and thermal images. VOCs were collected in standard sorbent tubes and subsequently analyzed using a Thermal Desorption/Gas Chromatograph/high sensitivity bench-top Time-of-Flight Mass Spectrometer (TD/GC/TOF-MS). A comprehensive, stage by stage, detailed information on the decay process is being presented based on the experimental macroscopic observations, justifying thus the use of @entity8 carcasses as surrogate material. A variety of VOCs were identified including almost all chemical classes: @entity3 , @entity7 , @entity1 compounds ( @entity9 , @entity11 , @entity17 , acids and @entity16 ), @entity12 , @entity5 and @entity14 . Carcasses obtained from a @entity8 farm resulted in more @entity3 and @entity7 cadaveric volatiles. @entity2 was by far the most abundant inorganic gas identified along with @entity4 , @entity10 and @entity13 . Visual monitoring was based on video captured images allowing for macroscopic observations, while thermal camera monitoring which is mostly temperature dependent, resulted in highlighting the local micro-changes on the carcasses, as a result of the intense microbial activity. The combination of chemical and optical methods proved very useful and informative, uncovering hidden aspects of the early stages of decay and also guiding in the development of combined chemical and imaging methods for the detection of dead bodies.

title: Combined chemical and optical methods for monitoring the early decay stages of surrogate XXXX models.

answer: @entity0