abstract: BACKGROUND: @entity9 and @entity10 , cell surface receptors of @entity3 , regulate cell migration and alteration of their expression has been associated with poor prognosis of @entity1 . The aim of this study was to detect their expression in @entity2 to identify associations with another cell adhesion molecule, @entity6 ( @entity6 ), and with clinicopathological data ex vivo, and then explore their potential role in @entity2 cells in vitro. MATERIALS AND METHODS: A total of 172 cases of @entity2 tissue specimens were collected for immunohistochemical analysis of @entity9 , @entity10 , and @entity6 expression. Expression of @entity9 and @entity10 proteins was knocked in or down using their cDNA and shRNA, respectively, in @entity2 cell lines to assess the changed cell phenotypes and gene expression. RESULTS: @entity9 , @entity10 , and @entity6 were expressed in 61.0%, 77.9%, and 75.6% of @entity2 tissues, respectively. Moreover, @entity9 and @entity10 expression was associated with @entity1 differentiations, advanced clinical stages, lymph node, and distant @entity0 of @entity2 . Similarly, @entity6 expression was associated with @entity9 and @entity10 . Expression of these three proteins was interrelated. In vitro study showed that levels of @entity9 and @entity10 proteins were associated with the capacity of @entity2 cell migration, while knockdown of their expression inhibited @entity2 cell migration and invasion abilities in vitro. In contrast, overexpression of @entity9 and @entity10 proteins promoted @entity1 cell migration and invasion. At the gene levels, knockdown of @entity9 or @entity10 expression suppressed expression of @entity11 , @entity8 , and @entity7 proteins and phosphorylated @entity4 and @entity5 . Conversely, upregulation of @entity9 or @entity10 promoted expression of @entity11 , @entity8 , @entity7 , and @entity4 proteins and phosphorylated @entity7 , @entity4 and @entity5 . CONCLUSIONS: These findings suggest that @entity9 and @entity10 play an important role in @entity2 progression. Further study will be performed to investigate whether target of their expression can be used as a novel strategy in clinical control of @entity2 @entity0 .

title: Association of CXCR1 and 2 expressions with @entity2 XXXX in ex vivo and @entity1 cell invasion in vitro.

answer: @entity0


abstract: BACKGROUND: @entity9 and @entity10 , cell surface receptors of @entity3 , regulate cell migration and alteration of their expression has been associated with poor prognosis of @entity1 . The aim of this study was to detect their expression in @entity2 to identify associations with another cell adhesion molecule, @entity6 ( @entity6 ), and with clinicopathological data ex vivo, and then explore their potential role in @entity2 cells in vitro. MATERIALS AND METHODS: A total of 172 cases of @entity2 tissue specimens were collected for immunohistochemical analysis of @entity9 , @entity10 , and @entity6 expression. Expression of @entity9 and @entity10 proteins was knocked in or down using their cDNA and shRNA, respectively, in @entity2 cell lines to assess the changed cell phenotypes and gene expression. RESULTS: @entity9 , @entity10 , and @entity6 were expressed in 61.0%, 77.9%, and 75.6% of @entity2 tissues, respectively. Moreover, @entity9 and @entity10 expression was associated with @entity1 differentiations, advanced clinical stages, lymph node, and distant @entity0 of @entity2 . Similarly, @entity6 expression was associated with @entity9 and @entity10 . Expression of these three proteins was interrelated. In vitro study showed that levels of @entity9 and @entity10 proteins were associated with the capacity of @entity2 cell migration, while knockdown of their expression inhibited @entity2 cell migration and invasion abilities in vitro. In contrast, overexpression of @entity9 and @entity10 proteins promoted @entity1 cell migration and invasion. At the gene levels, knockdown of @entity9 or @entity10 expression suppressed expression of @entity11 , @entity8 , and @entity7 proteins and phosphorylated @entity4 and @entity5 . Conversely, upregulation of @entity9 or @entity10 promoted expression of @entity11 , @entity8 , @entity7 , and @entity4 proteins and phosphorylated @entity7 , @entity4 and @entity5 . CONCLUSIONS: These findings suggest that @entity9 and @entity10 play an important role in @entity2 progression. Further study will be performed to investigate whether target of their expression can be used as a novel strategy in clinical control of @entity2 @entity0 .

title: Association of CXCR1 and 2 expressions with @entity2 @entity0 in ex vivo and XXXX cell invasion in vitro.

answer: @entity1


abstract: When @entity2 (AA) was given to a @entity0 which was previously heparinized, its arterial pressure began to fall. Indomethacin erased this vasodepressive power without modifying the sensitivity of the cardiovascular apparatus to @entity5 . Thus, it seems to depend on the biosynthesis of the @entity5 . This @entity1 action is used as an indication of natural factors which modify the biosynthesis of @entity5 in living subjects. @entity4 was used on 8 male @entity0 who had been fed normally, weighing 2.3-2.8 kg. The standard dose of .12 mg/kg of AA was injected in 80 seconds. 3 experiments were done without heparin, using a manometer in which the liquid had been made incoaguable by @entity3 . With 5 others, after injection of AA, the isotonic liquid with @entity3 was replaced by a manometer with heparin (20 mg/kg of heparin to avoid reabsorption of @entity3 during @entity1 ). Several injections of AA were given until a constant @entity1 action resulted; then 4 mg/kg of @entity4 were given and 10 minutes later, a new injection of AA. The results were: 1) With .12 mg/kg there was no @entity1 effect in the @entity0 without heparin. 2) A previous treatment with 4 mg/kg of @entity4 achieved a fall of 5-15%. 3) In heparinized @entity0 , after AA injections, there were falls of pressure which intensified and attained 25% 40 minutes after the heparin injection. 4) The injection of @entity4 obtained @entity1 of 45-50% in 5 @entity0 . It is concluded that in @entity0 @entity4 is an activator of the biosynthesis of @entity5 .

title: [Proceedings: Influence of @entity4 on the XXXX effect of @entity2 ].

answer: @entity1


abstract: When @entity2 (AA) was given to a @entity0 which was previously heparinized, its arterial pressure began to fall. Indomethacin erased this vasodepressive power without modifying the sensitivity of the cardiovascular apparatus to @entity5 . Thus, it seems to depend on the biosynthesis of the @entity5 . This @entity1 action is used as an indication of natural factors which modify the biosynthesis of @entity5 in living subjects. @entity4 was used on 8 male @entity0 who had been fed normally, weighing 2.3-2.8 kg. The standard dose of .12 mg/kg of AA was injected in 80 seconds. 3 experiments were done without heparin, using a manometer in which the liquid had been made incoaguable by @entity3 . With 5 others, after injection of AA, the isotonic liquid with @entity3 was replaced by a manometer with heparin (20 mg/kg of heparin to avoid reabsorption of @entity3 during @entity1 ). Several injections of AA were given until a constant @entity1 action resulted; then 4 mg/kg of @entity4 were given and 10 minutes later, a new injection of AA. The results were: 1) With .12 mg/kg there was no @entity1 effect in the @entity0 without heparin. 2) A previous treatment with 4 mg/kg of @entity4 achieved a fall of 5-15%. 3) In heparinized @entity0 , after AA injections, there were falls of pressure which intensified and attained 25% 40 minutes after the heparin injection. 4) The injection of @entity4 obtained @entity1 of 45-50% in 5 @entity0 . It is concluded that in @entity0 @entity4 is an activator of the biosynthesis of @entity5 .

title: [Proceedings: Influence of XXXX on the @entity1 effect of @entity2 ].

answer: @entity4


abstract: When @entity2 (AA) was given to a @entity0 which was previously heparinized, its arterial pressure began to fall. Indomethacin erased this vasodepressive power without modifying the sensitivity of the cardiovascular apparatus to @entity5 . Thus, it seems to depend on the biosynthesis of the @entity5 . This @entity1 action is used as an indication of natural factors which modify the biosynthesis of @entity5 in living subjects. @entity4 was used on 8 male @entity0 who had been fed normally, weighing 2.3-2.8 kg. The standard dose of .12 mg/kg of AA was injected in 80 seconds. 3 experiments were done without heparin, using a manometer in which the liquid had been made incoaguable by @entity3 . With 5 others, after injection of AA, the isotonic liquid with @entity3 was replaced by a manometer with heparin (20 mg/kg of heparin to avoid reabsorption of @entity3 during @entity1 ). Several injections of AA were given until a constant @entity1 action resulted; then 4 mg/kg of @entity4 were given and 10 minutes later, a new injection of AA. The results were: 1) With .12 mg/kg there was no @entity1 effect in the @entity0 without heparin. 2) A previous treatment with 4 mg/kg of @entity4 achieved a fall of 5-15%. 3) In heparinized @entity0 , after AA injections, there were falls of pressure which intensified and attained 25% 40 minutes after the heparin injection. 4) The injection of @entity4 obtained @entity1 of 45-50% in 5 @entity0 . It is concluded that in @entity0 @entity4 is an activator of the biosynthesis of @entity5 .

title: [Proceedings: Influence of @entity4 on the @entity1 effect of XXXX ].

answer: @entity2


abstract: OBJECTIVES: An exaggerated blood pressure (BP) response to exercise is associated with adverse cardiovascular outcomes, even in normotensive individuals. The purpose of this study was to compare myocardial function between normotensive individuals with and without an exaggerated BP response. METHODS: We evaluated global myocardial function using speckle tracking echocardiography in normotensive individuals. Two-dimensional speckle tracking echocardiography and a treadmill exercise test were performed simultaneously in 171 normotensive individuals (mean age: 48  8 years; 97 @entity0 ) without any structural @entity3 . RESULTS: Among 171 normotensive individuals, 19 (11%) exhibited an exaggerated BP response (>= 200 mmHg for @entity0 and >= 190 mmHg for @entity0 ) during the treadmill test. Conventional echocardiographic parameters were similar between the two groups. However, on strain analyses, the systolic and early @entity4 of the left ventricle (LV) and left atrium were lower in individuals with an exaggerated BP response to exercise. The peak @entity5 during exercise was inversely related to @entity3 of the LV (r=-0.35, P<0.01) and left atrium (r=-0.41, P<0.01). On multivariate analyses, an exaggerated BP response to exercise was shown to be an independent determinant of reduced global longitudinal strain of the LV (b=-0.20, P<0.05) and left atrium (b=-0.28, P<0.05). CONCLUSION: Normotensive individuals with an exaggerated BP response to exercise exhibit @entity2 . Even without apparent @entity1 , an exaggerated BP response could cause repeated increases in afterload and result in subclinical @entity2 .

title: An exaggerated blood pressure response to exercise is associated with subclinical XXXX in normotensive individuals.

answer: @entity2


abstract: PURPOSE: @entity6 ( @entity6 , MIM#310600) is an @entity2 characterized by severe @entity7 at birth. We report the results of causative @entity8 gene analysis in three male siblings with @entity6 and describe the associated phenotypes. METHODS: Three brothers with suspected @entity6 and their mother presented for clinical examination. After obtaining informed consent, DNA was extracted from the peripheral blood of the proband, one of his brothers and his unaffected mother. Exons 1-3 of the @entity8 gene were amplified by polymerase chain reaction (PCR), and direct sequencing was performed. Multiplex ligation-dependent probe amplification (MLPA) was also performed to search for copy number variants in the @entity8 gene. RESULTS: The clinical findings of the three brothers included no light perception, @entity4 , @entity5 , leukocoria, @entity3 and @entity1 . Exon 2 of the @entity8 gene was not amplified in the proband and one brother, even when the PCR primers for exon 2 were changed, whereas the other two exons showed no mutations by direct sequencing. MLPA analysis showed deletion of exon 2 of the @entity8 gene in the proband and one brother, while there was only one copy of exon 2 in the mother. CONCLUSION: @entity6 was diagnosed in three @entity0 from a Japanese family by clinical examination and was confirmed by genetic analysis. To localize the defect, confirmation of copy number variation by the MLPA method was useful in the present study.

title: Familial cases of XXXX detected by copy number analysis.

answer: @entity6


abstract: BACKGROUND: @entity3 remains a concern in general surgical practice. The significance lies in the resultant @entity4 , related morbidity and mortality, risk of @entity2 , permanent stoma creation and the effect on local recurrence and overall @entity0 survival in @entity1 cases. OBJECTIVES: This study serves to determine the leak rates and the mortality thereof related to colonic and rectal anastomoses at the University Hospital of the West Indies (UHWI) in Kingston, Jamaica. Independent factors contributing to @entity3 in these @entity0 will also be assessed and correlations determined. METHODS: A review of the medical records of one hundred and thirty-three cases of colonic and rectal anastomoses identified retrospectively over a three-year period provided relevant information for analysis. RESULTS: @entity3 were identified in twelve @entity0 , providing a leak rate of 9.0%. No 30-day mortality related to @entity3 was noted. Based on a multivariate analysis, male gender was identified as the sole independent factor related to @entity3 . Conclusion: Colorectal anastomotic leak rates at UHWI fell at the upper limit of leak rates typically quoted in the literature. No modifiable risk factor appeared to contribute to this leak rate. Early identification and intervention is critical in limiting mortality associated with @entity1 .

title: XXXX at the university hospital of the west indies: an analysis of risk factors.

answer: @entity1


abstract: KEY MESSAGE: Promising genome regions for improving cold tolerance of @entity1 were identified on chromosomes SBI-01, SBI-03, SBI-07, and SBI-10. @entity0 fluorescence had no major effect on growth rates at low temperatures. Developing fast growing @entity1 seedlings is an important breeding goal for temperate climates since low springtime temperatures are resulting in a prolonged juvenile development. The adaptation of @entity1 to tropical and subtropical highlands gives hint for certain genetic variation. The goals of the present study were to detect marker-trait associations for leaf and dry matter growth rate and for @entity0 fluorescence and content (SPAD) in relation to temperature. A diversity set comprising 194 genotypes was tested in eight controlled environments with temperatures ranging from 9.4 to 20.8   C. Significant marker-trait associations (p < 0.05) were identified for each individual temperature regime and on the parameters of regression analyses describing the responses of growth or @entity0 related traits to temperatures. The diversity set was fingerprinted with 171 diversity array technology (DArT) and 31 simple-sequence repeat (SSR) markers. SSRs were used to analyze the population structure while association studies were performed on DArT markers. Promising marker-trait associations for growth rates in relation to temperature were detected on chromosomes SBI-01, SBI-03, SBI-07, and SBI-10. Many promising loci were also significantly associated to the results obtained in individual low-temperature environments. Marker-trait associations for @entity0 content and fluorescence did occasionally co-locate to those for growth during juvenile development but there was no evidence supporting our hypothesis that seedling growth at low temperatures is largely influenced by SPAD or fluorescence.

title: Genetic dissection of temperature-dependent XXXX growth during juvenile development.

answer: @entity1


abstract: OBJECTIVE: To describe the baseline nutritional characteristics of a cohort of @entity4 ( @entity4 ) @entity0 attending a pre-dialysis clinic. SETTING: Outpatient clinic of a metropolitan tertiary teaching hospital in Sydney, Australia. SUBJECTS: All @entity4 @entity0 attending the multidisciplinary pre-dialysis assessment clinic between April 2002 and March  2008. METHODS: Retrospective analysis of data extracted from the routine initial nutrition assessment records. These included anthropometric and biochemical measures, Subjective Global Assessment, appetite score, presence of symptoms, dietary energy, protein, and other macro- and micronutrient intakes. RESULTS: Of the 210 @entity0 assessed, 60.5% were male; mean age was 65.7      13.6  years with a mean glomerular filtration rate of 17.3      6.5  mL/ @entity6 .73  m(2); 17.1% and 62.4% were underweight (body mass index <23  kg/m(2)) and overweight or @entity1 (BMI >= 26  kg/m(2)), respectively; 40.5% were rated as malnourished (Subjective Global Assessment scores B and C) with 19.0% overweight/ @entity1 and malnourished. Energy and protein intakes correlated positively with glomerular filtration rate, with r  =  0.17, P = .01, and r  =  0.29, P  <  .0001 respectively. Mean energy and protein intakes were 23.7      6.7  kcal/kg IBW/day and 1.18      0.42  g/kg IBW/day, with 62.6% and 13.1% not meeting the recommended intake, respectively. The positive predictive values (95%CI) of self-rated appetite score for energy and protein were 0.41 (0.36-0.45) and 0.92 (0.88-0.95), respectively, indicating subjective rating of a good appetite was associated with adequate protein but not energy intake. Fifty-one percent of the @entity0 experienced the symptoms, whereas 17.5% of the @entity0 self-imposed a dietary regimen inappropriately due to beliefs on dietary needs in @entity4 . Suboptimal nutrient intakes were observed, including @entity8 (41.2%), @entity3 (61.8%), @entity7 (67.6.2%), @entity5 (100.0%), and @entity2 (64.2%). CONCLUSION: @entity0 presented to the pre-dialysis assessment clinic with abnormal nutrition parameters associated with decreased renal function, symptoms burden, and poor dietary intake. This clinic may provide an opportunity to optimize the nutritional status of @entity4 @entity0 in the pre-dialysis period.

title: A high prevalence of abnormal nutrition parameters found in predialysis XXXX : is it a result of uremia or poor eating habits?

answer: @entity4


abstract: IMPORTANCE: Up-front treatment of older @entity0 with @entity2 can cause morbidity without clear survival benefit; however, most such @entity0 receive treatment instead of observation. The impact of physicians on the management approach is uncertain. OBJECTIVE: To determine the impact of physicians on the management of @entity2 with up-front treatment vs observation. DESIGN, SETTING, AND @entity0 : Retrospective cohort of @entity0 66 years and older with @entity2 diagnosed from 2006 through 2009. @entity0 and @entity1 characteristics were obtained from the Surveillance, Epidemiology, and End Results @entity1 registries. The diagnosing urologist, consulting radiation oncologist, @entity1 -directed therapy, and comorbid medical conditions were determined from linked Medicare claims. Physician characteristics were obtained from the American Medical Association Physician Masterfile. Mixed-effects models were used to evaluate management variation and factors associated with observation. MAIN OUTCOMES AND MEASURES: No @entity1 -directed therapy within 12 months of diagnosis (observation). RESULTS: A total of 2145 urologists diagnosed @entity2 in 12,068 @entity0 , of whom 80.1% received treatment and 19.9% were observed. The case-adjusted rate of observation varied widely across urologists, ranging from 4.5% to 64.2% of @entity0 . The diagnosing urologist accounted for 16.1% of the variation in up-front treatment vs observation, whereas @entity0 and @entity1 characteristics accounted for 7.9% of this variation. After adjustment for @entity0 and @entity1 characteristics, urologists who treat non- @entity2 (adjusted odds ratio [aOR], 0.71 [95% CI, 0.55-0.92]; P =   .01) and graduated in earlier decades (P =   .004) were less likely to manage low-risk disease with observation. Treated @entity0 were more likely to undergo prostatectomy (aOR, 1.71 [95% CI, 1.45-2.01]; P <   .001), cryotherapy (aOR, 28.2 [95% CI, 19.5-40.9]; P <   .001), brachytherapy (aOR, 3.41 [95% CI, 2.96-3.93]; P <   .001), or external-beam radiotherapy (aOR, 1.31 [95% CI, 1.08-1.58]; P =   .005) if their urologist billed for that treatment. Case-adjusted rates of observation also varied across consulting radiation oncologists, ranging from 2.2% to 46.8% of @entity0 . CONCLUSIONS AND RELEVANCE: Rates of management of @entity2 with observation varied widely across urologists and radiation oncologists. @entity0 whose diagnosis was made by urologists who treated @entity2 were more likely to receive up-front treatment and, when treated, more likely to receive a treatment that their urologist performed. Public reporting of physicians' @entity1 management profiles would enable informed selection of physicians to diagnose and manage @entity2 .

title: Physician variation in management of XXXX : a population-based cohort study.

answer: @entity2


abstract: BACKGROUND: It has not been shown whether accelerated rehabilitation following periacetabular osteotomy (PAO) is effective for early recovery. The purpose of this retrospective study was to compare complication rates in @entity0 with standard and accelerated rehabilitation protocols who underwent PAO. METHODS: Between January 2002 and August 2011, @entity0 with a lateral center-edge (CE) angle of   <   20  , showing good joint congruency with the hip in abduction, pre- or early stage of @entity2 , and age younger than 60 years were included in this study. We evaluated 156 hips in 138 @entity0 , with a mean age at the time of surgery of 30 years. Full weight-bearing with two crutches started 2 months postoperatively in 73 @entity0 (80 hips) with the standard rehabilitation protocol. In 65 @entity0 (76 hips) with the accelerated rehabilitation protocol, postoperative strengthening of the hip, thigh and core musculature was begun on the day of surgery as tolerated. The exercise program included active hip range of motion, and gentle isometric hamstring and quadriceps muscle sets; these exercises were performed for 30 minutes in the morning and 30 minutes in the afternoon with a physical therapist every weekday for 6 weeks. Full weight-bearing with two axillary crutches started on the day of surgery as tolerated. Complications were evaluated for 2 years. RESULTS: The clinical results at the time of follow-up were similar in the two groups. The average periods between the osteotomy and full-weight-bearing walking without support were 4.2 months and 6.9 months in @entity0 with the accelerated and standard rehabilitation protocols (P   <   0.001), indicating that the accelerated rehabilitation protocol could achieve earlier recovery of @entity0 . However, postoperative fractures of the ischial ramus and posterior column of the pelvis were more frequently found in @entity0 with the accelerated rehabilitation protocol (8/76) than in those with the standard rehabilitation protocol (1/80) (P   =   0.013). CONCLUSION: The accelerated rehabilitation protocol seems to have advantages for early muscle recovery in @entity0 undergoing PAO; however, @entity1 rates were unacceptably high in @entity0 with this protocol.

title: Early weight-bearing after periacetabular osteotomy leads to a high incidence of XXXX .

answer: @entity1


abstract: INRODUCTION: @entity3 results from irregular development of the nasomaxillary complex and @entity2 . Treatment of @entity3 in pediatric @entity0 is one of the biggest challenges in rhinology. Surgery may alter craniofacial growth patterns, and so it may be indicated only in the selected cases. The use of external nasal dilators is a relatively new treatment modality in nasal obstruction. OBJECTIVE: This study was performed to assess the efficacy of external nasal dilator in pediatric @entity3 @entity0 . METHODS: Seventy-six @entity0 who were diagnosed with @entity3 at our outpatient clinic were included in the study. The @entity0 were divided into 2 groups: the external nasal dilator group was composed of 48 @entity0 that had used an external nasal dilator for at least 1 month and still been using, while the control group was comprised of 28 @entity0 that had not received any treatment and had not used an external nasal dilator. The parents of the @entity0 were asked to complete the @entity1 18 questionnaire. In addition, the external nasal dilator group was asked to complete the questionnaire after stopping external nasal dilator use for 2 weeks and the control group also repeated the @entity1 18 questionnaire. RESULTS: The @entity1 18 questionnaire results were significantly different between the external nasal dilator group and the control group at the beginning of the study (i.e., when @entity0 in the external nasal dilator group were still using their dilators, P = 0.000). On the other hand, there was no difference between the 2 groups after the @entity0 in the external nasal dilator group had stopped using their external nasal dilator (P = 0.670). CONCLUSION: External nasal dilator use relieved @entity3 , which narrows the nasal valve. The results of this study suggest that external nasal dilator could be used in @entity0 that are not candidates for septoplasty.

title: Efficiency of external nasal dilators in pediatric XXXX .

answer: @entity3


abstract: OBJECTIVES: To describe the use of sonication and microcalorimetry in diagnosing @entity1 in a 27-year-old @entity0 with bilateral breast implants. METHODS: The removed breast implants were subjected to sonication and microcalorimetry. The microcalorimetry findings were correlated with conventional microbiologic methods. The time to detection of @entity3 was noted. RESULTS: The @entity0 had @entity2 of the right breast that enlarged within hours. Her @entity4 level was increased. Chest radiograph showed gas formation in the soft tissue lateral of the right breast. Surgery was performed: 300 mL (right breast) and 100 mL (left breast) of serous-purulent fluid were evacuated. @entity5 was cultured from the fluid 1 day after clinical presentation. Infection was diagnosed by microcalorimetry of sonication fluid in 1 hour and 21 minutes. The microcalorimetry curve from the right implant reached the peak earlier than did the left implant. CONCLUSION: Microcalorimetry will have a benefit in conditions in which rapid diagnosis of @entity3 is important.

title: XXXX after breast augmentation: rapid microbiologic detection by using sonication of removed implants and microcalorimetry.

answer: @entity1


abstract: OBJECTIVES: Cigarette smoking is the most important risk factor for @entity3 . The prognostic effect of cigarette smoking on disease recurrence and progression in @entity0 with non-muscle-invasive @entity3 (NMIBC), however, is still unclear. We evaluated the effect of smoking status and intensity, and timing of smoking cessation, on NMIBC prognosis. METHODS AND MATERIALS: A population-based series of @entity0 diagnosed with NMIBC from 1995 until 2010 was identified through the Netherlands Cancer Registry. Self-reported smoking history was obtained by a postal lifestyle questionnaire at study inclusion. Detailed clinical data concerning diagnosis, treatment, and disease course were collected retrospectively through a medical file survey. The association of smoking variables with recurrence- and progression-free survival of 963 @entity0 with primary NMIBC was studied using cumulative incidence curves and competing risk regression analyses. RESULTS: The study population comprised 181 never smokers (18.8%), 490 former smokers (50.9%), and 292 current smokers (30.3%) at the time of diagnosis. No statistically significant difference or trend in risk of recurrence (Ptrend = 0.47) or progression (Ptrend = 0.23) across the 3 smoking status categories was found. Moreover, no dose-response association was observed across categories of smoking quantity, duration, or cumulative exposure in relation to NMIBC prognosis. The timing of smoking cessation (i.e., ceased smoking>= 10y before diagnosis,<10y before diagnosis, vs. current smoker at diagnosis) did not significantly affect the risk of recurrence (Ptrend = 0.31) and progression (Ptrend = 0.19). CONCLUSIONS: Based on our study, smoking status, smoking intensity, or cessation at any time before diagnosis does not seem to alter the risks of recurrence and progression among @entity0 with NMIBC. @entity0 ' smoking history is not useful for the guidance of clinical management decisions. @entity0 should nevertheless be advised to quit considering the known beneficial effects on other non-NMIBC-related end points such as @entity2 and second @entity1 .

title: The effect of smoking and timing of smoking cessation on clinical outcome in non-muscle-invasive XXXX .

answer: @entity3


abstract: BACKGROUND: There are few prospective studies on the natural course of chronic @entity1 (CU) in @entity0 . OBJECTIVE: We sought to examine the natural history of CU in @entity0 and to identify predictors for remission. METHODS: @entity0 4 to 15 years of age with CU were investigated with a complete blood cell count, erythrocyte sedimentation rate, antinuclear antibody titer, complement CH50 level, thyroid studies, autologous serum skin test, skin-prick tests, food challenges, and stool examination for parasites. They were considered to be in remission if symptoms did not recur for at least 12 months without medication. RESULTS: In all, 92 @entity0 (53.3% female) with CU were recruited and followed up for a median duration of 4.3 years (range 2.5-5.8 years). @entity4 ( @entity4 ) was identified in 40% of the @entity0 . @entity5 was found in 8.7% and parasitic @entity3 in 5.4%. Remission rates at 1, 3, and 5  years after the onset of CU symptoms were 18.5%, 54%, and 67.7%, respectively. The remission rate did not differ in @entity4 compared with non- @entity4 . No predictor of CU remission was identified. LIMITATIONS: The basophil @entity2 release assay was not performed. CONCLUSION: @entity0 with CU have a favorable outcome. @entity4 did not have an intractable course.

title: The natural history of chronic XXXX in childhood: a prospective study.

answer: @entity1


abstract: PURPOSE: A number of @entity0 operated on for @entity6 continue to have @entity5 and abdominal distension for years after surgery. Some authors have proposed that @entity3 during surgery may induce @entity6 . The aim of the present study was to study the effects of @entity3 on the enteric nervous system of sigmoid colon in an animal model. METHODS: A surgical model of @entity3 was created. 34 adult @entity2 underwent a laparotomy where the marginal arterioles of the sigmoid colon were ligated. After that, a section in the middle segment of the sigmoid colon was performed followed by an @entity4 . The presence of @entity3 was assessed by measurement of visible light spectroscopy tissue oximetry and histological examination. Colonic function was assessed by evaluation of stool weight. @entity2 were killed at 1, 8 and 12 weeks after the operation. 12 @entity2 were sham-operated. Enteric nervous system was evaluated by means of immunohistochemistry with @entity7 p75. Quantitative analysis of the number of @entity1 and ganglion cells in the myenteric plexus was performed. RESULTS: The surgical model of @entity3 significantly decreased tissue oxygenation (pre-surgical = 54.69    7.32 %; post-surgical = 27.37    9.2 %; p < 0.001). There was no disturbance in body-weight gaining in experimental groups and daily stool output did not vary after surgery (pre-surgical = 4.24    0.94 g; post-surgical = 3.82    1 g; p = 0.09). All experimental groups showed persistent @entity1 . However, there was a significant decrease in the number of @entity1 in all the experimental groups compared to control (1w: 45.91    7.66; 8w: 44.17    10.56; 12w: 36.17    15.06 vs control: 56.88    8.66; p < 0.01). The number of total ganglion cells was significantly reduced only in the experimental group killed at week 12 compared to control (1w: 539    167.58; 8w: 488.58    154.41; 12w: 343.94    161.91 vs control: 513.96    126.97; p < 0.01). The rate of ganglion cells per @entity1 was significantly higher in the groups killed at week 1 and 8 versus control group (1w: 11.63    2.53; 8w: 11.11    2.56; 12w: 9.34    1.16 vs control: 9.02    1.81; p < 0.05). CONCLUSION: Long-term follow-up after surgically induced @entity3 in the @entity2 showed a decreased number of ganglion cells and @entity1 . Nevertheless, it did not produce @entity6 .

title: Surgical acquired XXXX : myth or reality?

answer: @entity6


abstract: OBJECTIVE: @entity2 is one of the most common mental illnesses. The reliability and the validity of the @entity0 Health Questionnaire (PHQ)-9, a @entity2 screening tool, have not been examined in the general population in China. Thus, this study evaluated the reliability and the validity of the Chinese version of the PHQ-9 in detecting major @entity2 in residents of a Chinese community. METHODS: A total of 1045 @entity0 from a Shanghai community were enrolled in our study. @entity0 completed the Chinese versions of the PHQ-9, the Self-Rating @entity2 Scale ( @entity1 ), the 36-item Short Form Health Survey (SF-36), and the Mini International Neuropsychiatric Interview. One hundred @entity0 were randomly selected to complete the PHQ-9 again 2 weeks after the initial assessment. The reliability, the validity and the receiver operating characteristic (ROC) curve of the PHQ-9 were analyzed. RESULTS: Cronbach's alpha for the internal consistency reliability of the Chinese version of the PHQ-9 was 0.86 for the entire scale. The correlation coefficient for the 2-week test-retest of the total score was 0.86. The PHQ-9 scale correlated positively with the @entity1 (r=0.29, p<0.001) and correlated negatively with all subscale scores of the SF-36 (correlation coefficients ranged from -0.11 to -0.47, p<0.001). The area under the curve of the ROC was 0.92 (95% confidence interval: 0.86-0.97). A cutoff score of 7 or higher on the PHQ-9 had a sensitivity of 0.86 and a specificity of 0.86. CONCLUSIONS: In the general Chinese population, the Chinese version of the PHQ-9 is a valid and efficient tool for screening @entity2 , with a recommended cutoff score of 7 or more.

title: Reliability and validity of the Chinese version of the XXXX Health Questionnaire (PHQ-9) in the general population.

answer: @entity0


abstract: BACKGROUND: Recent descriptions of the clinical and laboratory features of subjects with @entity10 in the US are lacking. Our aim was to describe clinical, biochemical and genetic features of 108 subjects. METHODS: Between Sep 2010-Dec 2012, 108 subjects with @entity10 [90 acute intermittent @entity9 , 9 @entity12 , 9 variegate @entity9 ] were enrolled into an observational study. Genetic testing was performed at a central genetic testing laboratory and clinical information entered into a central data base. Selected features were compared to data for adults in the USA. RESULTS: Most subjects [88/108, 81%] were female with self-reported onset of symptoms in 2(nd)-4(th) decades of life. The most common symptom was @entity7 . Appendectomies and cholecystectomies were common prior to a diagnosis of @entity9 . The diagnosis was delayed by a mean of 15 years. @entity3 and @entity6 were common, and 18% complained of chronic symptoms, especially @entity0 . The incidences of and @entity4 arterial @entity1 , @entity8 , @entity5 , and @entity2 conditions were markedly increased. Mutations of the known causative genes were found in 102/105 of those tested, with novel mutations being found in 37 including in 7/8 subjects with @entity12 . Therapy with intravenous @entity11 was the most effective therapy both for treatment of acute attacks and for prevention of recurrent attacks. CONCLUSIONS: @entity10 often remain undiagnosed for more than a decade after first symptoms develop. Intravenous hematin is the treatment of choice, both for treatment of acute attacks and for prevention of recurrent attacks. TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01561157.

title: XXXX in the USA: Features of 108 Subjects from Porphyria Consortium.

answer: @entity10


abstract: BACKGROUND AND OBJECTIVE: @entity7 , which is characterized by increased @entity4 levels and reduced HDL @entity3 levels, is underestimated and undertreated in clinical practice. We assessed its prevalence and the achievement of therapeutic objectives for HDL @entity3 and @entity4 levels in @entity0 treated at lipid and vascular risk units in Spain. @entity0 AND METHOD: This was an observational, longitudinal, retrospective, multicenter study performed in 14 autonomous Spanish communities that consecutively included 1828 @entity0 aged >= 18 years who were referred for @entity7 and vascular risk to 43 lipid clinics accredited by the Spanish Society of @entity8 . We collected information from the medical records corresponding to 2 visits conducted during 2010 and 2011-12, respectively. RESULTS: Of the 1649 @entity0 who had a lipid profile in the first visit (90.2%), 295 (17.9%) had @entity7 . The factors associated with @entity7 were excess weight/ @entity2 , not taking hypolipidemic drugs (statins and/or fibrates), @entity1 , @entity5 and previous @entity6 . Of the 273 (92.5%) @entity0 with @entity7 that had a lipid profile in the last visit, 44 (16.1%) achieved the therapeutic objectives for HDL @entity3 and @entity4 levels. The predictors of therapeutic success were normal weight and normoglycemia. CONCLUSION: One of every 6 @entity0 treated in lipid and vascular risk units had @entity7 . The degree to which the therapeutic goals for HDL @entity3 and @entity4 levels were achieved in these @entity0 was very low.

title: XXXX : prevalence and management in lipid clinics.

answer: @entity7


abstract: BACKGROUND: Anti-neutrophil cytoplasm antibody (ANCA) associated @entity4 with @entity1 requires treatment with potentially toxic drugs to reduce morbidity and mortality, and there is a major challenge to determine clinical and histological features predictive of renal prognosis. The aim of our study was to evaluate the use of the 2010 international histological classification for ANCA-associated @entity3 (AAGN) as a predictor of renal outcome when used in conjunction with other prognostic factors. METHODS: One hundred and four @entity0 with AAGN treated at our centre were included: 23 were classified as focal, 26 as crescentic, 48 as mixed and 7 as @entity6 . Renal outcomes were based on estimated glomerular filtration rate (eGFR) at 1 and 5 years, and on renal survival. RESULTS: By univariate analysis, @entity0 in the focal class had the best renal outcome, those in the @entity6 class the worst outcome, and those in the mixed and crescentic classes had intermediate renal survival. There was no significant difference in outcome between the mixed and crescentic classes. In multivariate models, histological class did not improve model fit or associate with renal outcome after adjusting for established prognostic factors. Lower percentage of normal glomeruli, greater degree of @entity2 ( @entity2 ), @entity5 -ANCA positivity, increasing age and lower starting eGFR, all correlated with poorer renal outcomes. CONCLUSIONS: We conclude that, in our cohort of @entity0 , the international histological classification is predictive of renal outcome in AAGN, but did not appear to be additionally informative over other established prognostic factors in multivariate analysis. However, it may be of value to combine the current histological classification with other established parameters, such as @entity2 and percentage normal glomeruli.

title: Long-term outcome of anti-neutrophil cytoplasm antibody-associated XXXX : evaluation of the international histological classification and other prognostic factors.

answer: @entity3


abstract: AIMS: The aim of the study was to study the clinical profile of the @entity0 with @entity1 ( @entity1 ) and @entity2 . SETTINGS AND DESIGN: This was a prospective, cross sectional, hospital-based study done at the Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India from September 2009 to January 2011. All @entity0 with @entity1 , diagnosed by United Kingdom @entity1 Society Brain Bank criteria, having with features of @entity2 as diagnosed by the neuropsychiatric inventory (NPI) were included. @entity0 without a caregiver who could validate the @entity0 's symptoms were excluded. RESULTS: A total of 40 @entity0 (5 @entity0 , 35 @entity0 ) with @entity1 with @entity2 (mean age: 54.2    11.5 years, mean duration of illness: 6.5    4.5 years, and mean duration of @entity2 : 4.3    4.3 years) were included in the study. The Global NPI score was 19.1    11.5. Majority of the @entity0 had pure @entity3 (85%), while the rest had either pure delusions (7.5%) or a combination of delusions and @entity3 (7.5%). In those with @entity3 , @entity3 were the commonest (60%) (pure only in 22.5%), followed by auditory (45%), minor @entity3 (45%), and tactile (20%). Only one @entity0 reported having @entity3 (2.5%). Loss of insight was most often observed during the @entity3 (52%), followed by tactile (44.4%), auditory (38.9 %), and minor @entity3 (33.3%). CONCLUSIONS: In @entity0 with @entity1 and @entity2 , pure @entity3 are common and @entity3 are the commonest among the @entity3 . A large proportion of @entity0 have minor @entity3 , which need to be recognized early for effective and early management. The limitations of the study were small sample size, use of a single scale to assess @entity2 and subjective assessment of insight.

title: A clinical profile of @entity0 with @entity1 and XXXX .

answer: @entity2


abstract: AIMS: The aim of the study was to study the clinical profile of the @entity0 with @entity1 ( @entity1 ) and @entity2 . SETTINGS AND DESIGN: This was a prospective, cross sectional, hospital-based study done at the Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India from September 2009 to January 2011. All @entity0 with @entity1 , diagnosed by United Kingdom @entity1 Society Brain Bank criteria, having with features of @entity2 as diagnosed by the neuropsychiatric inventory (NPI) were included. @entity0 without a caregiver who could validate the @entity0 's symptoms were excluded. RESULTS: A total of 40 @entity0 (5 @entity0 , 35 @entity0 ) with @entity1 with @entity2 (mean age: 54.2    11.5 years, mean duration of illness: 6.5    4.5 years, and mean duration of @entity2 : 4.3    4.3 years) were included in the study. The Global NPI score was 19.1    11.5. Majority of the @entity0 had pure @entity3 (85%), while the rest had either pure delusions (7.5%) or a combination of delusions and @entity3 (7.5%). In those with @entity3 , @entity3 were the commonest (60%) (pure only in 22.5%), followed by auditory (45%), minor @entity3 (45%), and tactile (20%). Only one @entity0 reported having @entity3 (2.5%). Loss of insight was most often observed during the @entity3 (52%), followed by tactile (44.4%), auditory (38.9 %), and minor @entity3 (33.3%). CONCLUSIONS: In @entity0 with @entity1 and @entity2 , pure @entity3 are common and @entity3 are the commonest among the @entity3 . A large proportion of @entity0 have minor @entity3 , which need to be recognized early for effective and early management. The limitations of the study were small sample size, use of a single scale to assess @entity2 and subjective assessment of insight.

title: A clinical profile of @entity0 with XXXX and @entity2 .

answer: @entity1


abstract: AIMS: The aim of the study was to study the clinical profile of the @entity0 with @entity1 ( @entity1 ) and @entity2 . SETTINGS AND DESIGN: This was a prospective, cross sectional, hospital-based study done at the Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India from September 2009 to January 2011. All @entity0 with @entity1 , diagnosed by United Kingdom @entity1 Society Brain Bank criteria, having with features of @entity2 as diagnosed by the neuropsychiatric inventory (NPI) were included. @entity0 without a caregiver who could validate the @entity0 's symptoms were excluded. RESULTS: A total of 40 @entity0 (5 @entity0 , 35 @entity0 ) with @entity1 with @entity2 (mean age: 54.2    11.5 years, mean duration of illness: 6.5    4.5 years, and mean duration of @entity2 : 4.3    4.3 years) were included in the study. The Global NPI score was 19.1    11.5. Majority of the @entity0 had pure @entity3 (85%), while the rest had either pure delusions (7.5%) or a combination of delusions and @entity3 (7.5%). In those with @entity3 , @entity3 were the commonest (60%) (pure only in 22.5%), followed by auditory (45%), minor @entity3 (45%), and tactile (20%). Only one @entity0 reported having @entity3 (2.5%). Loss of insight was most often observed during the @entity3 (52%), followed by tactile (44.4%), auditory (38.9 %), and minor @entity3 (33.3%). CONCLUSIONS: In @entity0 with @entity1 and @entity2 , pure @entity3 are common and @entity3 are the commonest among the @entity3 . A large proportion of @entity0 have minor @entity3 , which need to be recognized early for effective and early management. The limitations of the study were small sample size, use of a single scale to assess @entity2 and subjective assessment of insight.

title: A clinical profile of XXXX with @entity1 and @entity2 .

answer: @entity0


abstract: Two adult @entity0 presented with the rare @entity2 ( @entity2 ). Case 1: A 35-year-old male @entity0 had progressive stiffness of lower limbs of 13 years and generalized @entity9 and @entity5 of 3 years duration. Had periorbital @entity1 , dry skin, generalized @entity9 and @entity10 with hoarseness. Muscle power was normal. Jaw jerk and deep tendon reflexes were exaggerated. Case 2: A 24-year-old male @entity0 presented with @entity9 from childhood, slowness in motor activities and @entity3 . For 6 months, he had severe @entity5 , cramps and further increase in @entity6 . He had yellow tinged, dry skin, hoarseness of voice, gross @entity9 and minimal weakness. Both had markedly elevated serum @entity4 kinase (CK) levels and high thyroid stimulating hormone, low free @entity7 and free @entity8 levels. @entity8 treatment demonstrated remarkable reduction in muscle bulk at 2 months in both and no symptoms at 6 months. Magnetic resonance imaging of lower limbs in both cases revealed almost identical features with involvement of the muscles of posterior and adductor compartment of thighs and posterior and lateral compartments of the legs. Differential diagnosis of long duration muscle pseudohypertrophy and elevated CK levels should include @entity2 .

title: XXXX with unusually long duration: Report on clinical, laboratory and muscle imaging findings in two cases.

answer: @entity2


abstract: Background. Staging and treatment of @entity2 has yet to be formalized. We sought to determine the utility of the pediatric classification system in adults and determine the efficacy of different treatment modalities. Methods. Medical records of 118 adults ( @entity0 >17 years old) and 112 pediatric @entity0 (ages 2-17), who were treated for @entity2 at M.D. Anderson @entity1 Center from January 1994 to September 2012, were reviewed. International @entity2 risk group (INRG) variables were abstracted. The primary outcome of interest was actuarial progression-free survival. Results. Median age of pediatric @entity0 was 5 years (range 3-16) and 47 years (range 18-82) for adult @entity0 . There were no differences in PFS or OS between stage-matched risk categories between pediatric and adult @entity0 (L1-P = 0.40, L2-P = 0.54, and M-P = 0.73). In the treatment of L1 disease, median PFS for adults treated with surgery and radiation was 11.1 months compared with single modality local treatment    chemotherapy (6.4 and 5.1 months, resp.; P = 0.07). Median PFS in L2 adult @entity0 was 5.2 months with local therapy and 4 months with the addition of chemotherapy (P = 0.23). Conclusions. Adult and pediatric @entity0 with @entity2 achieve similar survival outcomes. INRG classification should be employed to stratify @entity2 @entity0 and help select treatment.

title: Adult versus Pediatric XXXX : The M.D. Anderson @entity1 Center Experience.

answer: @entity2


abstract: Background. Staging and treatment of @entity2 has yet to be formalized. We sought to determine the utility of the pediatric classification system in adults and determine the efficacy of different treatment modalities. Methods. Medical records of 118 adults ( @entity0 >17 years old) and 112 pediatric @entity0 (ages 2-17), who were treated for @entity2 at M.D. Anderson @entity1 Center from January 1994 to September 2012, were reviewed. International @entity2 risk group (INRG) variables were abstracted. The primary outcome of interest was actuarial progression-free survival. Results. Median age of pediatric @entity0 was 5 years (range 3-16) and 47 years (range 18-82) for adult @entity0 . There were no differences in PFS or OS between stage-matched risk categories between pediatric and adult @entity0 (L1-P = 0.40, L2-P = 0.54, and M-P = 0.73). In the treatment of L1 disease, median PFS for adults treated with surgery and radiation was 11.1 months compared with single modality local treatment    chemotherapy (6.4 and 5.1 months, resp.; P = 0.07). Median PFS in L2 adult @entity0 was 5.2 months with local therapy and 4 months with the addition of chemotherapy (P = 0.23). Conclusions. Adult and pediatric @entity0 with @entity2 achieve similar survival outcomes. INRG classification should be employed to stratify @entity2 @entity0 and help select treatment.

title: Adult versus Pediatric @entity2 : The M.D. Anderson XXXX Center Experience.

answer: @entity1


abstract: The effect of low intensity laser radiation in the treatment of acute and @entity3 is now established in many studies. Tri-geminal @entity1 is a @entity2 passes through nerve's branches and its trigger is located in skin or mucosa that could lead to @entity2 with a trigger stimulus. The @entity2 involved branches of trigeminal nerve that sometimes has @entity0 to seek the treatment for several years. Nowadays different treatments are used for relief of @entity2 that most of them cause tolerance and various side effects. This paper reviews and summarizes scientific papers available in English literature publishedin PubMed, Scopus, Science Direct, Inter science, and Iran Medex from 1986 until July 2011 about the effect of these types of lasers on @entity4 which is one of the most @entity2 afflictions known. In different studies, the effect of laser therapy has been compared with placebo irradiation or medicinal and surgical treatment modalities. Low-level laser therapy (LLLT) is a treatment strategy which uses a single wavelength light source. Laser radiation and monochromatic light may alter cell and tissue function. However, in most studies laser therapy was associated with significant reduction in the intensity and frequency of @entity2 compared with other treatment strategies, a few studies revealed that between laser and placebo group there was not any significant difference according to the analgesic effect. Low-level laser therapy could be considered in treatment of @entity4 without any side effects.

title: The Effect of Low-level Laser Therapy on Trigeminal XXXX : A Review of Literature.

answer: @entity1


abstract: BACKGROUND: Aim of our study was to determine the predictive impact of certain serum immunological markers on @entity5 ( @entity5 ) in @entity0 with @entity3 ( @entity3 ). METHODS: We assayed prospectively values of @entity4 ( @entity4 ), immunoglobulin G (IgG), C4, CD3+, @entity1 + and @entity2 + cells via flow cytometry, enzyme-linked immunosorbent assay (ELISA) and radial immunodiffusion in preoperative sera of adult @entity0 with de novo histologically confirmed supratentorial @entity3 . Kaplan-Meier method and Cox proportional hazards models were used to assess clinical, laboratory, and treatment prognostic factors for @entity5 . RESULTS: Twenty-six consecutive @entity0 were identified with a mean age of 59.6 years. Median follow up was 12 months. Lower @entity4 values (<7.97 pg/ml vs. >= 7.97 pg/ml, P = 0.029) und @entity1 + counts (<200 cells/ l vs. >= 200 cells/ l, P < 0.001) correlated significantly with a shorter @entity5 . The independent prognostic relevance of @entity1 + counts was confirmed by the multivariate analysis (HR = 0.010, 95% CI 0.001-0.226, P = 0.011). Further independent prognostic factors for @entity5 were type of resection (resection vs. biopsy) and administration of radiotherapy (yes/no). CONCLUSION: Preoperative values @entity4 and @entity1 + cells in sera may carry a prognostic impact. Novel diagnostic models prior to histopathological confirmation may be used to predict prognosis of @entity0 with @entity3 . Future studies should investigate whether targeting immune factors, such as @entity1 + and @entity4 , may improve the prognosis of @entity0 with @entity3 .

title: Prognostic value of the preoperative immunological profile in @entity0 with XXXX .

answer: @entity3


abstract: BACKGROUND: Aim of our study was to determine the predictive impact of certain serum immunological markers on @entity5 ( @entity5 ) in @entity0 with @entity3 ( @entity3 ). METHODS: We assayed prospectively values of @entity4 ( @entity4 ), immunoglobulin G (IgG), C4, CD3+, @entity1 + and @entity2 + cells via flow cytometry, enzyme-linked immunosorbent assay (ELISA) and radial immunodiffusion in preoperative sera of adult @entity0 with de novo histologically confirmed supratentorial @entity3 . Kaplan-Meier method and Cox proportional hazards models were used to assess clinical, laboratory, and treatment prognostic factors for @entity5 . RESULTS: Twenty-six consecutive @entity0 were identified with a mean age of 59.6 years. Median follow up was 12 months. Lower @entity4 values (<7.97 pg/ml vs. >= 7.97 pg/ml, P = 0.029) und @entity1 + counts (<200 cells/ l vs. >= 200 cells/ l, P < 0.001) correlated significantly with a shorter @entity5 . The independent prognostic relevance of @entity1 + counts was confirmed by the multivariate analysis (HR = 0.010, 95% CI 0.001-0.226, P = 0.011). Further independent prognostic factors for @entity5 were type of resection (resection vs. biopsy) and administration of radiotherapy (yes/no). CONCLUSION: Preoperative values @entity4 and @entity1 + cells in sera may carry a prognostic impact. Novel diagnostic models prior to histopathological confirmation may be used to predict prognosis of @entity0 with @entity3 . Future studies should investigate whether targeting immune factors, such as @entity1 + and @entity4 , may improve the prognosis of @entity0 with @entity3 .

title: Prognostic value of the preoperative immunological profile in XXXX with @entity3 .

answer: @entity0


abstract: @entity5 ( @entity5 ), a rare and highly @entity4 that presents in early childhood, has a poor prognosis. @entity3 /RTs are characterized by biallelic inactivating mutations of the gene @entity6 in 98% of @entity0 ; these mutations may serve as molecular markers for @entity2 cell detection in liquid biopsies. We developed a marker-specific method to detect residual @entity5 cells. Seven of 150 @entity0 samples were selected, each with a histological and genetically ascertained diagnosis of @entity5 . @entity1 tissue was either formalin fixed or fresh frozen. DNA was extracted from the @entity0 ' peripheral blood leukocytes (PBL) and cerebrospinal fluid (CSF). Multiplex ligation-dependent probe amplification, DNA sequencing, and fluorescence in situ hybridization were used to characterize the @entity1 ' mutations. @entity2 cell detection used mutation-specific primers and real-time PCR. The detection limit for the @entity2 cell search was 1-18%, depending on the quality of the template provided. The @entity2 cell search in PBL and CSF was negative for all seven @entity0 . The @entity6 region of chromosome 22 is prone to DNA double-strand breaks. The individual breakpoints and breakpoint-specific PCR offer the option to detect minimal @entity2 cells in CSF or blood. Even if we did not detect minimal @entity2 cells in the investigated material, proof of principle for this method was confirmed.

title: Identifying molecular markers for the sensitive detection of residual atypical XXXX cells.

answer: @entity5


abstract: AIM: The aim of this retrospective study was to compare the results of two different mesh fixation methods in laparoscopic transabdominal preperitoneal hernioplasty (TAPP): tacker vs. synthetic cyanoacrylate glue. METHODS: The study group includes 70 @entity0 with bilateral and monolateral recurrent inguinal @entity5 undergoing transabdominal preperitoneal repair (TAPP) in the period 2011-2013. A @entity11 mesh was fixed in group A (N.=35) with @entity6 tacks (EndoUniversal stapler, Covidien) or in group B (N.=35) with synthetic @entity9 glue (Glubran-2, GEM). @entity0 outcome was assessed by the following variables: sex, mean age, ASA score, intra- and postoperative morbidity, hospitalization, postoperative acute and @entity7 , recurrence rate. The observation period was 24 months, with a mean follow-up of 10.5 months (range, 1-23) for Group A and 11 months (range, 2-24) for Group B. RESULTS: No difference between the two groups was observed with respect to mean operative time and hospitalization. In all cases, surgery was successfully concluded laparoscopically. @entity10 occurred in 1 @entity0 of the group A and consisted of a urinary @entity8 , which was immediately sutured. @entity3 rate was 5.7% (4 @entity0 , of whom 3 in group A and 1 in group B). In each group we detected one recurrence within 6 (group A) and 18 months (group B) postsurgery; both @entity0 were treated with a re-TAPP. @entity4 at 6 months from surgery, measured by visual analogue score (VAS), was reported by 4 @entity0 in the group A and in no case of the group B (P=0.04). CONCLUSION: Data from this study demonstrate the advantages of synthetic cyanoacrylate glue for mesh fixation in laparoscopic transabdominal preperitoneal @entity2 , compared to @entity6 tacks. The use of this surgical glue was associated with a significantly reduced risk for developing chronic @entity1 and a shortened hospital stay. Nevertheless, further studies with longer follow-up periods are needed to confirm our encouraging results.

title: [Comparison between two different mesh fixation methods in laparoscopic XXXX : tacker vs. Synthetic cyanoacrylate glue.]

answer: @entity2


abstract: OBJECTIVES: To examine gender and racial disparities in @entity1 mortality related to metalworking fluid exposures and in the healthy worker survivor effect. METHOD: We examined @entity1 ( @entity1 ) mortality from 1941 to 1995 in a cohort of autoworkers with quantitative exposure to cumulative respirable particulate matter from water-based metalworking fluids. Cox models were used to estimate the exposure-response to soluble and synthetic fluids separately in white @entity0 , black @entity0 , and white @entity0 . In separate analyses, we used g-estimation to adjust for the healthy worker survivor effect. RESULTS: The risk of @entity1 was increased among black @entity0 (295 deaths) exposed to synthetic fluid with a hazard ratio (HR) of 3.47 (95% CI: 1.52, 7.92) in the highest cumulative exposure category. White @entity0 (119 deaths) had increased risk of @entity1 with increased soluble fluid (HR: 2.44 (0.93, 6.38)) in the second to highest category. However, Cox models show no increased risk in white @entity0 (2246 deaths). In contrast, g-estimation results indicate that if white @entity0 had been always unexposed to soluble and synthetic fluid, then on average for each case, 2.99 and 2.77 years of life would have been saved, respectively. CONCLUSIONS: We found increased risk of @entity1 for black @entity0 and white @entity0 exposed to metalworking fluids using Cox regression. After adjusting for the healthy worker survivor effect, increased risk was observed for white @entity0 . The ability to leave work for health related reasons may be an option more available to white male workers.

title: 0103   Racial and Gender Differences in the Risk of XXXX and the Healthy Worker Survivor Effect among Autoworkers.

answer: @entity1


abstract: OBJECTIVES: Selection of appropriate outcome measures in studies of work-related @entity0 ( @entity0 ) directly affects the observed exposure-response relationship. Considering that many different factors might affect different stages of disease severity, we examined disability outcomes that represent a spectrum of disease in a newly hired working population and described the transitions between various states of symptoms and disability. METHOD: From July 2004 to October 2006, 1107 newly hired workers were recruited to participate in the study. Subjects completed self-reported questionnaires including demographics, medical and work history, and current symptom and work status, nerve conduction studies, and a physical exam. Surveys were repeated at 6, 18, and 36 month follow-up; 827 subjects (75%) completed all follow-ups and were included in the analysis. The outcomes of interest were presence of @entity1 and limitations in work abilities, productivity, job restrictions, lost time, and job changes due to these symptoms. RESULTS: A majority of workers (72%) reported symptoms at least once during the study, yet less than half (44-46%) reported symptoms within any single follow-up period. Similarly, 31% of workers reported work limitations due to their symptoms at least once during the study, but only 15-16% within any single follow-up period. CONCLUSIONS: These results provide evidence for the dynamic nature of both @entity2 symptoms and work abilities over time, which has been theorised but with few explicit studies. If the risk factors for these outcomes differ, this may explain some of the lack of clarity in the current literature on work-related risk factors and @entity2 .

title: 0356   Transitions between upper XXXX and work limitation outcomes: a prospective study.

answer: @entity0


abstract: BACKGROUND: @entity1 control is an integral part of minor oral surgery and maxillary/mandibular nerve blocks have proved promising in achieving the same. Although intra oral techniques of @entity3 are common and are widely used, there are certain inherent disadvantages and potential complications. Less commonly described in the literature, the extra oral techniques have a wide spectrum of indications as well as can be more advantageous than the intra oral approach. This prospective clinical trial is an attempt to evaluate the feasibility and the efficacy of the extra oral frontozygomatic approach to the foramen rotundum to block the maxillary nerve. MATERIALS AND METHODS: Sample size was 100 @entity0 and the inclusion criteria were @entity0 of ASA I or II category who needed extraction of a minimum of 4 maxillary teeth in the same quadrant in a single sitting while exclusion criteria were @entity0 with a history of @entity2 to local anesthesia, medically compromised @entity0 in whom dental extraction was contraindicated. Mean age was 71.9  years and 56 @entity0 were males while 44 were females. Only a single quadrant (first or second) was chosen as the operative site in each @entity0 and local anaesthesia was secured using a 21 gauge 89  mm long spinal needle with frontozygomatic angle approach and the parameters used were @entity1 experienced during the injection, onset of subjective symptoms, time required for the peak effect (objective symptoms), @entity1 during extraction and the duration of anesthesia. All the parameters were expressed as mean values with standard deviations. RESULTS: A successful anesthesia was secured in first attempt in 98 @entity0 while in 2 @entity0 , the procedure had to be repeated owing to the difficulty in reaching the target site. A majority of the @entity0 i.e., 71  % scored 0-2 (no @entity1 ) on visual analogue scale (VAS) while only 2 @entity0 experienced a moderate degree of @entity1 . Subjective symptoms were reported in 27.24  s (mean value) and 12.93  s (mean value) in the palate and the infraorbital fossa respectively. Peak effect of anesthesia was noted in 66.7, 37.38 and 31.71  s (all values expressed as mean) in palate, infraorbital fossa and posterior superior alveolar areas respectively. CONCLUSION: Although with only dental extraction as the procedure of choice, the present study has favoured the frontozygomatic angle approach for the @entity3 as simple, safe, efficacious and associated with minimum and clinically mild complications.

title: Efficacy and feasibility of frontozygomatic angle approach for extra XXXX in oral surgery: a descriptive clinical trial.

answer: @entity3


abstract: BACKGROUND: Poor oral health, @entity2 , functional decline, and low cognitive ability can increase the risk of falls in the elderly. OBJECTIVES: The current study aimed to show the effects of oral health, @entity0 ( @entity0 ), @entity1 ( @entity1 ), @entity3 , functional status, and sociodemographic factors on the risk of falls in elderly with @entity4 . MATERIALS AND METHODS: The sample comprised 1,210 Malaysian elderly who were demented and noninstitutionalized. This study was a national cross-sectional survey entitled "Determinants of Health Status among Older Malaysians". The effects of age, ethnicity, sex differences, marital status, educational level, oral health, @entity0 , @entity1 , @entity3 , and functional status on the risk of falls were evaluated. The multiple logistic regression model was used to estimate the effects of contributing variables on the risk of falls in samples. RESULTS: The prevalence of falls was approximately 17% in subjects. It was found that age (odds ratio [OR] 1.02), non-Malay ethnicity (OR 1.66), @entity3 (OR 1.92), and functional decline (OR 1.58) significantly increased the risk of falls in respondents (P<0.05). Furthermore, having teeth (OR 0.59) and dentures (OR 0.66) significantly decreased the rate of falls (P<0.05). CONCLUSION: It was concluded that age, non-Malay ethnicity, functional decline, @entity3 , and oral health significantly affected falls in @entity4 .

title: Association between dentures and the rate of falls in XXXX .

answer: @entity4


abstract: BACKGROUND: @entity4 , @entity2 , and @entity1 are all part of the symptom triad in @entity3 ( @entity3 ). Despite the fact that @entity2 and @entity1 may be early manifestations of @entity3 , the clinical diagnosis is conventionally based on the presence of @entity4 and a positive genetic test for the @entity3 CAG repeat expansion. After investigating the frequencies of the triad manifestations in a large outpatient clinical cohort of @entity3 gene-expansion carriers, we propose a new clinical classification. METHODS: In this cross-sectional study, 107 gene-expansion carriers from a Danish outpatient clinic were recruited. All @entity0 underwent neurological examination, @entity2 evaluation and neuropsychological testing. @entity0 were categorised according to motor symptoms, @entity2 , the use of psychotropic medication, and @entity1 . RESULTS: Among the motor manifest @entity3 gene-expansion carriers, 51.8% presented with the full symptom triad, 25.0% were defined as @entity1 in addition to motor symptoms, and 14.3% had @entity2 along with motor symptoms. Only 8.9% had isolated motor symptoms. Among gene-expansion carriers without motor symptoms, 39.2% had @entity2 , were @entity1 , or had a combination of the two. CONCLUSION: This is the first study to report the frequencies of both motor symptoms, @entity1 , and @entity2 in @entity3 gene-expansion carriers in a national outpatient @entity3 clinical cohort. We found that almost 40% of the gene-expansion carriers without motor symptoms had either @entity2 , @entity1 or both, emphasising that these @entity0 are not premanifest in @entity2 and cognitive terms, suggesting that the current clinical classification is neither necessarily suitable nor helpful for this @entity0 group. Some premanifest gene-expansion carriers may have @entity2 and/or cognitive symptoms caused by reactive stress or other pathology than @entity3 . Acknowledging this fact we, however, suggest classifying all @entity3 gene-expansion carriers into three clinical categories: premanifest, non-motor manifest, and motor manifest.

title: A clinical classification acknowledging @entity1 in XXXX .

answer: @entity3


abstract: BACKGROUND: @entity4 , @entity2 , and @entity1 are all part of the symptom triad in @entity3 ( @entity3 ). Despite the fact that @entity2 and @entity1 may be early manifestations of @entity3 , the clinical diagnosis is conventionally based on the presence of @entity4 and a positive genetic test for the @entity3 CAG repeat expansion. After investigating the frequencies of the triad manifestations in a large outpatient clinical cohort of @entity3 gene-expansion carriers, we propose a new clinical classification. METHODS: In this cross-sectional study, 107 gene-expansion carriers from a Danish outpatient clinic were recruited. All @entity0 underwent neurological examination, @entity2 evaluation and neuropsychological testing. @entity0 were categorised according to motor symptoms, @entity2 , the use of psychotropic medication, and @entity1 . RESULTS: Among the motor manifest @entity3 gene-expansion carriers, 51.8% presented with the full symptom triad, 25.0% were defined as @entity1 in addition to motor symptoms, and 14.3% had @entity2 along with motor symptoms. Only 8.9% had isolated motor symptoms. Among gene-expansion carriers without motor symptoms, 39.2% had @entity2 , were @entity1 , or had a combination of the two. CONCLUSION: This is the first study to report the frequencies of both motor symptoms, @entity1 , and @entity2 in @entity3 gene-expansion carriers in a national outpatient @entity3 clinical cohort. We found that almost 40% of the gene-expansion carriers without motor symptoms had either @entity2 , @entity1 or both, emphasising that these @entity0 are not premanifest in @entity2 and cognitive terms, suggesting that the current clinical classification is neither necessarily suitable nor helpful for this @entity0 group. Some premanifest gene-expansion carriers may have @entity2 and/or cognitive symptoms caused by reactive stress or other pathology than @entity3 . Acknowledging this fact we, however, suggest classifying all @entity3 gene-expansion carriers into three clinical categories: premanifest, non-motor manifest, and motor manifest.

title: A clinical classification acknowledging XXXX in @entity3 .

answer: @entity1


abstract: BACKGROUND: Nanoparticles have become one of the leading technologies over the past two years. The extensive use of nanoparticles has raised great concern about their occupational fate and biological effects. With an increase in the production and use of nanomaterial, it is more likely to get exposed to them occupationally and environmentally. OBJECTIVE: To assess the @entity2 of @entity3 nanoparticles on @entity0 mononuclear cells. METHODS: In this in vitro experimental study, suspensions of blood mononuclear cells from 10 young healthy @entity0 were incubated with 10-nm @entity3 nanoparticles in different concentrations (range: 1-500  g/mL) for 6 and 24 hours by @entity1 assay. Positive and negative controls were used for comparison. RESULTS: After 6 hours of exposure, 10.9% to 48.4% of the cells died. After 24 hours of exposure, the rate ranged from 56.8% to 86.3%. Regardless of the exposure time, the maximum @entity2 was observed at the concentration of 500  g/mL of @entity3 nanoparticles. By increasing the exposure time to 24 hours, the @entity2 of nanoparticles substantially increased at all concentrations. Cell death was significantly higher when compared to the controls (p<0.01). CONCLUSION: @entity3 nanoparticles possess both time- and dose-dependent @entity2 and can thus be considered as very toxic for mononuclear cells.

title: The toxic effects of XXXX nanoparticles on blood mononuclear cells.

answer: @entity3


abstract: BACKGROUND _ OBJECTIVES: Staging of @entity3 is done clinically using International Federation of Obstetrics and Gynecology (FIGO) guidelines. It is based on physical examination findings and also includes results of biopsy, endoscopy and conventional radiological tests like chest radiograph, intravenous urography and barium enema. These conventional radiological investigations have largely been replaced by computed tomography (CT) and magnetic resonance imaging (MRI) at present. FIGO staging system does not consider CT and MRI mandatory; however, use of these modalities are encouraged. This prospective study was conducted to determine the role of CT in staging work up in @entity0 diagnosed with @entity3 . METHODS: Fifty three @entity0 diagnosed with @entity3 were evaluated with contrast enhanced CT scan of abdomen and pelvis. CT scan images were especially evaluated to determine @entity1 size, invasion of parmetrium, pelvic walls, rectum, urinary bladder and ureters, pelvic or @entity4 and distant metastases. CT findings were associated with clinical findings and staging, including findings from cystoscopy and sigmoidoscopy. RESULTS: There was a poor agreement between clinical and @entity1 . Primary @entity1 was demonstrated on CT in 36 (70%) of 53 @entity0 . CT underestimated the parametrial, vaginal and pelvic wall invasion when compared with physical examination. CT overestimated the urinary bladder and rectal invasion when compared with cysto-sigmoidoscopy, however, CT had 100 per cent negative predictive value (NPV) to exclude @entity2 . CT detection of lymph node enlargement and lung metastases influenced the management. INTERPRETATION _ CONCLUSIONS: Our findings show that CT scan does not reliably correlate with clinical FIGO staging of cervical @entity1 . However, it can detect urinary obstruction as well as nodal or distant metastases and thus improves the clinical FIGO staging.

title: Role of computed tomography (CT) scan in staging of XXXX .

answer: @entity3


abstract: PURPOSE: Little is known about the clinicopathological features of early @entity4 ( @entity4 ). The purpose of this study was to compare the clinicopathological features and prognosis between @entity0 with early @entity4 and those with early nonmucinous @entity4 (NMGC). METHODS: We reviewed the records of 2,732 @entity0 diagnosed with @entity4 who were treated surgically. There were 14 @entity0 (0.5%) with early @entity4 and 958 with early NMGC. RESULTS: Early @entity4 @entity0 had a higher prevalence of elevated type (71.4%) compared with early NMGC @entity0 (29.5%). More early @entity4 @entity0 had @entity3 , compared with early NMGC @entity0 (78.6% vs. 64.1%). The overall 5-year survival of the @entity0 with early @entity4 was 97.2% as compared with 92.7% for the @entity0 with early NMGC (P < 0.01). The statistically significant prognostic parameters influencing the 5-year survival rate according to Cox's proportional hazard regression model were: age (risk ratio, 2.22; 95% confidence interval [CI], 1.62-3.04; P < 0.01); sex (risk ratio, 1.97; 95% CI, 1.42-2.73; P < 0.01); and lymph node @entity1 (risk ratio, 1.88; 95% CI, 1.28-2.77; P < 0.01). CONCLUSION: @entity0 with early @entity4 had a better prognosis than those with early NMGC. Mucinous histology itself appears not to be an independent prognostic factor. Therefore, early detection is important for improving the prognosis for @entity0 with @entity4 regardless of @entity2 histology.

title: Prognosis of early XXXX .

answer: @entity4


abstract: Mucosal alterations of the fallopian tube are generally thought to represent alterations of the native tubal mucosal epithelium, whether benign or malignant. The current paradigm implicating the fallopian tube fimbriae as the origin of most pelvic high-grade serous @entity2 (HGSCs) is based on the premise that HGSC growing within the tubal mucosa originated there. This has fueled proposals to redefine classification rules for assigning the primary site of origin on the basis of the presence or absence of HGSC in the tubal mucosa. The corollary is that it is unlikely for @entity2 to @entity10 . Evidence to support or refute this corollary is minimal, in part because the fallopian tubes historically have been ignored. This study reports the pattern and topography of 100 nongynecologic @entity1 that metastasized to the fallopian tubes. Most @entity1 were @entity3 (87%), and the remainder included @entity4 , and @entity8 . The most common primary origins of @entity1 were the colon (35%) and breast (15%). Gross evidence of a tubal nodule or mass was only seen in 35% of cases. Ovarian @entity0 were present in 95% of cases, although 23% did not exhibit gross evidence of @entity0 . @entity1 involved the fimbriae in 49% of cases, including 10% of cases in which the @entity1 was restricted to the fimbriae without involving the nonfimbriated portion of the tube. The anatomic distribution of @entity0 included the tubal mucosa (29%), submucosa (43%), muscularis (54%), serosa (76%), lymphovascular spaces (38%), intraluminal space (16%), and mesonephric remnants (39%). The most common architectural pattern of @entity5 was a flat layer (22/29 cases), followed by varying degrees of stratification, tufting, and papillary growth. High-grade atypia was present in 18/29 cases of @entity5 , resulting in patterns that resembled primary tubal HGSC. Accompanying growth in the tubal submucosa frequently produced a pseudoinvasive pattern mimicking invasive tubal HGSC. Immunohistochemical expression of @entity6 by 8/18 high-grade mucosal @entity0 further contributed to the resemblance to primary tubal HGSC. Bland cytology was present in 11/29 cases of @entity5 , some of which also exhibited mucinous features, resulting in patterns that resembled either @entity9 or nonmucinous @entity7 . Although uncommon, it is possible for @entity0 of nongynecologic @entity1 to @entity10 and create a potential diagnostic pitfall. Intramucosal growth of a @entity1 in the fallopian tube is not pathognomonic of a primary tubal origin of the @entity1 . These findings may carry implications for proposed criteria using the status of the fallopian tube mucosa to assign primary origin of a @entity1 .

title: Nongynecologic @entity10 : a potential mimic of tubal high-grade serous @entity2 or nonmucinous XXXX .

answer: @entity7


abstract: Mucosal alterations of the fallopian tube are generally thought to represent alterations of the native tubal mucosal epithelium, whether benign or malignant. The current paradigm implicating the fallopian tube fimbriae as the origin of most pelvic high-grade serous @entity2 (HGSCs) is based on the premise that HGSC growing within the tubal mucosa originated there. This has fueled proposals to redefine classification rules for assigning the primary site of origin on the basis of the presence or absence of HGSC in the tubal mucosa. The corollary is that it is unlikely for @entity2 to @entity10 . Evidence to support or refute this corollary is minimal, in part because the fallopian tubes historically have been ignored. This study reports the pattern and topography of 100 nongynecologic @entity1 that metastasized to the fallopian tubes. Most @entity1 were @entity3 (87%), and the remainder included @entity4 , and @entity8 . The most common primary origins of @entity1 were the colon (35%) and breast (15%). Gross evidence of a tubal nodule or mass was only seen in 35% of cases. Ovarian @entity0 were present in 95% of cases, although 23% did not exhibit gross evidence of @entity0 . @entity1 involved the fimbriae in 49% of cases, including 10% of cases in which the @entity1 was restricted to the fimbriae without involving the nonfimbriated portion of the tube. The anatomic distribution of @entity0 included the tubal mucosa (29%), submucosa (43%), muscularis (54%), serosa (76%), lymphovascular spaces (38%), intraluminal space (16%), and mesonephric remnants (39%). The most common architectural pattern of @entity5 was a flat layer (22/29 cases), followed by varying degrees of stratification, tufting, and papillary growth. High-grade atypia was present in 18/29 cases of @entity5 , resulting in patterns that resembled primary tubal HGSC. Accompanying growth in the tubal submucosa frequently produced a pseudoinvasive pattern mimicking invasive tubal HGSC. Immunohistochemical expression of @entity6 by 8/18 high-grade mucosal @entity0 further contributed to the resemblance to primary tubal HGSC. Bland cytology was present in 11/29 cases of @entity5 , some of which also exhibited mucinous features, resulting in patterns that resembled either @entity9 or nonmucinous @entity7 . Although uncommon, it is possible for @entity0 of nongynecologic @entity1 to @entity10 and create a potential diagnostic pitfall. Intramucosal growth of a @entity1 in the fallopian tube is not pathognomonic of a primary tubal origin of the @entity1 . These findings may carry implications for proposed criteria using the status of the fallopian tube mucosa to assign primary origin of a @entity1 .

title: Nongynecologic @entity10 : a potential mimic of tubal high-grade serous XXXX or nonmucinous @entity7 .

answer: @entity2


abstract: Mucosal alterations of the fallopian tube are generally thought to represent alterations of the native tubal mucosal epithelium, whether benign or malignant. The current paradigm implicating the fallopian tube fimbriae as the origin of most pelvic high-grade serous @entity2 (HGSCs) is based on the premise that HGSC growing within the tubal mucosa originated there. This has fueled proposals to redefine classification rules for assigning the primary site of origin on the basis of the presence or absence of HGSC in the tubal mucosa. The corollary is that it is unlikely for @entity2 to @entity10 . Evidence to support or refute this corollary is minimal, in part because the fallopian tubes historically have been ignored. This study reports the pattern and topography of 100 nongynecologic @entity1 that metastasized to the fallopian tubes. Most @entity1 were @entity3 (87%), and the remainder included @entity4 , and @entity8 . The most common primary origins of @entity1 were the colon (35%) and breast (15%). Gross evidence of a tubal nodule or mass was only seen in 35% of cases. Ovarian @entity0 were present in 95% of cases, although 23% did not exhibit gross evidence of @entity0 . @entity1 involved the fimbriae in 49% of cases, including 10% of cases in which the @entity1 was restricted to the fimbriae without involving the nonfimbriated portion of the tube. The anatomic distribution of @entity0 included the tubal mucosa (29%), submucosa (43%), muscularis (54%), serosa (76%), lymphovascular spaces (38%), intraluminal space (16%), and mesonephric remnants (39%). The most common architectural pattern of @entity5 was a flat layer (22/29 cases), followed by varying degrees of stratification, tufting, and papillary growth. High-grade atypia was present in 18/29 cases of @entity5 , resulting in patterns that resembled primary tubal HGSC. Accompanying growth in the tubal submucosa frequently produced a pseudoinvasive pattern mimicking invasive tubal HGSC. Immunohistochemical expression of @entity6 by 8/18 high-grade mucosal @entity0 further contributed to the resemblance to primary tubal HGSC. Bland cytology was present in 11/29 cases of @entity5 , some of which also exhibited mucinous features, resulting in patterns that resembled either @entity9 or nonmucinous @entity7 . Although uncommon, it is possible for @entity0 of nongynecologic @entity1 to @entity10 and create a potential diagnostic pitfall. Intramucosal growth of a @entity1 in the fallopian tube is not pathognomonic of a primary tubal origin of the @entity1 . These findings may carry implications for proposed criteria using the status of the fallopian tube mucosa to assign primary origin of a @entity1 .

title: Nongynecologic XXXX : a potential mimic of tubal high-grade serous @entity2 or nonmucinous @entity7 .

answer: @entity10


abstract: @entity1 and @entity6 ( @entity5 ) play a role in the short-term inhibition of food intake. It is known that peripheral injection of @entity5 increases @entity4 -immunoreactivity (Fos-IR) in the nucleus of the solitary tract (NTS) in @entity0 , and injection of the @entity1 antagonist @entity3 decreases the number of @entity4 -IR cells in the NTS. This supports the idea of @entity1 contributing to the effects of @entity5 . The aim of the present study was to elucidate whether peripherally injected @entity5 -8S modulates the concentration of @entity1 in brain feeding-regulatory nuclei. Ad libitum fed male @entity0 received 5.2 and 8.7 nmol/kg @entity5 -8S (n=3/group) or 0.15M NaCl (n=3-5/group) injected intraperitoneally (ip). The number of @entity4 -IR neurons, and the fluorescence intensity of @entity1 in nerve fibers were assessed in the paraventricular nucleus (PVN), @entity2 ( @entity2 ), NTS and dorsal motor nucleus of the vagus ( @entity7 ). @entity5 -8S increased the number of @entity4 -ir neurons in the NTS (mean  SEM: 72  4, and 112  5 neurons/section, respectively) compared to vehicle-treated @entity0 (7  2 neurons/section, P<0.05), but did not modulate @entity4 expression in the @entity7 or @entity2 . Additionally, @entity5 -8S dose-dependently increased the number of @entity4 -positive neurons in the PVN (218  15 and 128  14, respectively vs. 19  5, P<0.05). In the NTS and @entity7 we observed a decrease of @entity1 -immunoreactivity 90 min after injection of @entity5 -8S (46  2 and 49  8 pixel/section, respectively) compared to vehicle (81  8 pixel/section, P<0.05). No changes of @entity1 -immunoreactivity were observed in the PVN and @entity2 . Our results suggest that @entity1 is involved in the mediation of @entity5 -8's effects in the brainstem.

title: Peripheral injected XXXX -8S modulates the concentration of @entity1 in nerve fibers of the @entity0 brainstem.

answer: @entity6


abstract: @entity1 and @entity6 ( @entity5 ) play a role in the short-term inhibition of food intake. It is known that peripheral injection of @entity5 increases @entity4 -immunoreactivity (Fos-IR) in the nucleus of the solitary tract (NTS) in @entity0 , and injection of the @entity1 antagonist @entity3 decreases the number of @entity4 -IR cells in the NTS. This supports the idea of @entity1 contributing to the effects of @entity5 . The aim of the present study was to elucidate whether peripherally injected @entity5 -8S modulates the concentration of @entity1 in brain feeding-regulatory nuclei. Ad libitum fed male @entity0 received 5.2 and 8.7 nmol/kg @entity5 -8S (n=3/group) or 0.15M NaCl (n=3-5/group) injected intraperitoneally (ip). The number of @entity4 -IR neurons, and the fluorescence intensity of @entity1 in nerve fibers were assessed in the paraventricular nucleus (PVN), @entity2 ( @entity2 ), NTS and dorsal motor nucleus of the vagus ( @entity7 ). @entity5 -8S increased the number of @entity4 -ir neurons in the NTS (mean  SEM: 72  4, and 112  5 neurons/section, respectively) compared to vehicle-treated @entity0 (7  2 neurons/section, P<0.05), but did not modulate @entity4 expression in the @entity7 or @entity2 . Additionally, @entity5 -8S dose-dependently increased the number of @entity4 -positive neurons in the PVN (218  15 and 128  14, respectively vs. 19  5, P<0.05). In the NTS and @entity7 we observed a decrease of @entity1 -immunoreactivity 90 min after injection of @entity5 -8S (46  2 and 49  8 pixel/section, respectively) compared to vehicle (81  8 pixel/section, P<0.05). No changes of @entity1 -immunoreactivity were observed in the PVN and @entity2 . Our results suggest that @entity1 is involved in the mediation of @entity5 -8's effects in the brainstem.

title: Peripheral injected @entity6 -8S modulates the concentration of XXXX in nerve fibers of the @entity0 brainstem.

answer: @entity1


abstract: @entity1 and @entity6 ( @entity5 ) play a role in the short-term inhibition of food intake. It is known that peripheral injection of @entity5 increases @entity4 -immunoreactivity (Fos-IR) in the nucleus of the solitary tract (NTS) in @entity0 , and injection of the @entity1 antagonist @entity3 decreases the number of @entity4 -IR cells in the NTS. This supports the idea of @entity1 contributing to the effects of @entity5 . The aim of the present study was to elucidate whether peripherally injected @entity5 -8S modulates the concentration of @entity1 in brain feeding-regulatory nuclei. Ad libitum fed male @entity0 received 5.2 and 8.7 nmol/kg @entity5 -8S (n=3/group) or 0.15M NaCl (n=3-5/group) injected intraperitoneally (ip). The number of @entity4 -IR neurons, and the fluorescence intensity of @entity1 in nerve fibers were assessed in the paraventricular nucleus (PVN), @entity2 ( @entity2 ), NTS and dorsal motor nucleus of the vagus ( @entity7 ). @entity5 -8S increased the number of @entity4 -ir neurons in the NTS (mean  SEM: 72  4, and 112  5 neurons/section, respectively) compared to vehicle-treated @entity0 (7  2 neurons/section, P<0.05), but did not modulate @entity4 expression in the @entity7 or @entity2 . Additionally, @entity5 -8S dose-dependently increased the number of @entity4 -positive neurons in the PVN (218  15 and 128  14, respectively vs. 19  5, P<0.05). In the NTS and @entity7 we observed a decrease of @entity1 -immunoreactivity 90 min after injection of @entity5 -8S (46  2 and 49  8 pixel/section, respectively) compared to vehicle (81  8 pixel/section, P<0.05). No changes of @entity1 -immunoreactivity were observed in the PVN and @entity2 . Our results suggest that @entity1 is involved in the mediation of @entity5 -8's effects in the brainstem.

title: Peripheral injected @entity6 -8S modulates the concentration of @entity1 in nerve fibers of the XXXX brainstem.

answer: @entity0


abstract: Endocrine disrupting compounds (EDCs) of natural or synthetic origin can interfere with the balance of the hormonal system, either by altering hormone production, secretion, transport, or their binding and consequently lead to an adverse outcome in intact animals. An important aspect is the prediction of effects of combined exposure to two or more EDCs at the same time. The @entity2 @entity0 assay (YES) is a broadly used method to assess estrogenic potential of chemicals. Besides exhibiting good predictivity to identify compounds which interfere with the @entity0 receptor, it is easy to handle, rapid and therefore allows screening of a large number of single compounds and varying mixtures. Herein, we applied the YES assay to determine the potential combination effects of binary mixtures of two estrogenic compounds, @entity4 and @entity3 , as well as one classical @entity1 that in vitro also exhibits estrogenic activity, @entity5 . In addition to generating data from combined exposure, we fitted these to a four-parametric logistic dose-response model. As all compounds tested share the same mode of action dose additivity was expected. To assess this, the Loewe model was utilized. Deviations between the Loewe additivity model and the observed responses were always small and global tests based on the whole dose-response data set indicated in general a good fit of the Loewe additivity model. At low concentrations concentration additivity was observed, while at high concentrations, the observed effect was lower than additivity, most likely reflecting receptor saturation. In conclusion, our results suggest that binary combinations of @entity3 , @entity4 and @entity5 in the YES assay do not deviate from expected additivity.

title: Effect of estrogenic binary mixtures in the @entity2 XXXX screen (YES).

answer: @entity0


abstract: Endocrine disrupting compounds (EDCs) of natural or synthetic origin can interfere with the balance of the hormonal system, either by altering hormone production, secretion, transport, or their binding and consequently lead to an adverse outcome in intact animals. An important aspect is the prediction of effects of combined exposure to two or more EDCs at the same time. The @entity2 @entity0 assay (YES) is a broadly used method to assess estrogenic potential of chemicals. Besides exhibiting good predictivity to identify compounds which interfere with the @entity0 receptor, it is easy to handle, rapid and therefore allows screening of a large number of single compounds and varying mixtures. Herein, we applied the YES assay to determine the potential combination effects of binary mixtures of two estrogenic compounds, @entity4 and @entity3 , as well as one classical @entity1 that in vitro also exhibits estrogenic activity, @entity5 . In addition to generating data from combined exposure, we fitted these to a four-parametric logistic dose-response model. As all compounds tested share the same mode of action dose additivity was expected. To assess this, the Loewe model was utilized. Deviations between the Loewe additivity model and the observed responses were always small and global tests based on the whole dose-response data set indicated in general a good fit of the Loewe additivity model. At low concentrations concentration additivity was observed, while at high concentrations, the observed effect was lower than additivity, most likely reflecting receptor saturation. In conclusion, our results suggest that binary combinations of @entity3 , @entity4 and @entity5 in the YES assay do not deviate from expected additivity.

title: Effect of estrogenic binary mixtures in the XXXX @entity0 screen (YES).

answer: @entity2


abstract: Abstract @entity5 ( @entity5 ) to @entity4 has been shown to increase the risk of cardiovascular events. Platelet-derived microvesicles (PMVs) may be prothrombotic and contribute to the risk of recurrent events observed in @entity0 with @entity5 . However, PMVs may also serve as biomarkers and be used to assess platelet function. We investigated the association between platelet responses to @entity4 (measured by whole blood impedance aggregometry) and circulating PMVs in @entity0 with @entity3 ( @entity3 ). Blood samples were obtained at discharge from 200 @entity0 with @entity3 who had undergone percutaneous coronary intervention (PCI). All @entity0 were loaded with @entity1 and @entity4 before PCI. @entity2 -induced whole blood impedance aggregometry and measurement of PMVs were performed. Cut-off values for @entity5 and other reactivity (i.e. normal on-treatment reactivity, NPR and low on-treatment reactivity, LPR) to @entity4 were set according to data from large prospective studies. We measured PMVs as phosphatidylserine and @entity8 positive vesicles, together with @entity6 or @entity7 , using flow cytometry. @entity2 -induced platelet aggregation revealed that approximately 20% of @entity0 had @entity5 . Levels of PMVs were almost two-fold higher in the @entity5 group compared with @entity0 without @entity5 (for both @entity8 - and @entity6 -positive PMVs, p   <   0.01). Furthermore, @entity0 with LPR to @entity4 had significantly fewer PMVs exposing @entity6 than @entity0 with @entity5 or those with NPR to @entity4 . @entity0 with @entity5 during @entity4 treatment have elevated levels of circulating PMVs, indicating ongoing platelet activation despite @entity4 treatment. Moreover, in @entity0 with LPR to @entity4 , circulating @entity9 numbers are decreased. Taken together, our data suggest that PMVs are potential biomarkers of antiplatelet responses to @entity4 . If PMVs also have prognostic value after, @entity3 should be tested in future studies.

title: Association between platelet reactivity and circulating platelet-derived microvesicles in @entity0 with XXXX .

answer: @entity3


abstract: Abstract @entity5 ( @entity5 ) to @entity4 has been shown to increase the risk of cardiovascular events. Platelet-derived microvesicles (PMVs) may be prothrombotic and contribute to the risk of recurrent events observed in @entity0 with @entity5 . However, PMVs may also serve as biomarkers and be used to assess platelet function. We investigated the association between platelet responses to @entity4 (measured by whole blood impedance aggregometry) and circulating PMVs in @entity0 with @entity3 ( @entity3 ). Blood samples were obtained at discharge from 200 @entity0 with @entity3 who had undergone percutaneous coronary intervention (PCI). All @entity0 were loaded with @entity1 and @entity4 before PCI. @entity2 -induced whole blood impedance aggregometry and measurement of PMVs were performed. Cut-off values for @entity5 and other reactivity (i.e. normal on-treatment reactivity, NPR and low on-treatment reactivity, LPR) to @entity4 were set according to data from large prospective studies. We measured PMVs as phosphatidylserine and @entity8 positive vesicles, together with @entity6 or @entity7 , using flow cytometry. @entity2 -induced platelet aggregation revealed that approximately 20% of @entity0 had @entity5 . Levels of PMVs were almost two-fold higher in the @entity5 group compared with @entity0 without @entity5 (for both @entity8 - and @entity6 -positive PMVs, p   <   0.01). Furthermore, @entity0 with LPR to @entity4 had significantly fewer PMVs exposing @entity6 than @entity0 with @entity5 or those with NPR to @entity4 . @entity0 with @entity5 during @entity4 treatment have elevated levels of circulating PMVs, indicating ongoing platelet activation despite @entity4 treatment. Moreover, in @entity0 with LPR to @entity4 , circulating @entity9 numbers are decreased. Taken together, our data suggest that PMVs are potential biomarkers of antiplatelet responses to @entity4 . If PMVs also have prognostic value after, @entity3 should be tested in future studies.

title: Association between platelet reactivity and circulating platelet-derived microvesicles in XXXX with @entity3 .

answer: @entity0