abstract: OBJECTIVE: To evaluate the clinical effectiveness of bolus-dose @entity6 and @entity5 to treat @entity4 in @entity0 with severe @entity3 . DESIGN: Retrospective cohort. SETTING: PICU in a university-affiliated @entity0 's hospital level I @entity2 center. @entity0 : Thirty-one @entity0 0-18 years of age with severe @entity3 (Glasgow Coma Scale score of  <= 8) who received bolus doses of @entity6 and/or @entity5 for treatment of @entity4 . INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The area under the curve from high-resolution intracranial pressure-time plots was calculated to represent cumulative intracranial @entity1 exposure: area under the curve for intracranial pressure above 20 mm Hg (area under the curve-intracranial @entity1 ) was calculated in 15-minute epochs before and after administration of @entity6 and/or @entity5 for the treatment of @entity4 . Our primary outcome measure, the difference between predrug and postdrug administration epochs (  area under the curve-intracranial @entity1 ), was calculated for all occurrences. We examined potential covariates including age, injury severity, mechanism, and time after injury; time after injury correlated with   area under the curve-intracranial @entity1 . In a mixed-effects model, with @entity0 as a random effect, drug/dose combination as a fixed effect, and time after injury as a covariate, intracranial @entity1 increased after administration of @entity6 and/or @entity5 (overall aggregate mean   area under the curve-intracranial @entity1 = +17 mm Hg * min, 95% CI, 0-34 mm Hg * min; p = 0.04). The mean   area under the curve-intracranial @entity1 increased significantly after administration of high-dose @entity6 (p = 0.02), low-dose @entity5 (p = 0.006), and high-dose @entity6 plus low-dose @entity5 (0.007). Secondary analysis using age-dependent thresholds showed no significant impact on cerebral perfusion pressure deficit (mean   area under the curve-cerebral perfusion pressure). CONCLUSIONS: Bolus dosing of @entity6 and @entity5 fails to reduce the intracranial @entity1 burden when administered for @entity4 . Paradoxically, we observed an overall increase in intracranial @entity1 burden following drug administration, even after accounting for within-subject effects and time after injury. Future work is needed to confirm these findings in a prospective study design.

title: @entity6 and XXXX Are Ineffective in Reducing @entity4 in Severe Pediatric @entity3 .

answer: @entity5


abstract: BACKGROUND: Open reading frames are common in long noncoding RNAs (lncRNAs) and 5'UTRs of protein coding transcripts (uORFs). The question of whether those ORFs are translated was recently addressed by several groups using ribosome profiling. Most of those studies concluded that certain lncRNAs and uORFs are translated, essentially based on computational analysis of ribosome footprints. However, @entity3 remain on the scope of translation and the translational status of individual ORFs. In consequence, further criteria are required to reliably identify translated ORFs from ribosome profiling data. RESULTS: We examined the effect of the translation inhibitors @entity6 , @entity7 and @entity4 on @entity1 @entity2 cell ribosome footprints. We found that @entity6 , a drug that targets eIF4A, allows a far more accurate identification of translated sequences than previously used drugs and computational scoring schemes. Our data show that at least one third but less than two thirds of @entity2 cell lncRNAs are translated. We also identified translated uORFs in hundreds of annotated coding transcripts including key pluripotency transcripts, such as dicer, @entity5 , @entity8 , and ctcf. CONCLUSION: @entity6 inhibition data clearly increase the precision of the detection of translated ORFs in ribosome profiling experiments. Our data show that translation of lncRNAs and uORFs in @entity1 @entity2 cells is rather common although less pervasive than previously suggested. The observation of translated uORFs in several key pluripotency transcripts suggests that translational regulation by uORFs might be part of the network that defines @entity0 stem cell identity.

title: XXXX -sensitive ribosome profiling reveals the scope of translation in @entity1 embryonic stem cells.

answer: @entity6


abstract: BACKGROUND: Open reading frames are common in long noncoding RNAs (lncRNAs) and 5'UTRs of protein coding transcripts (uORFs). The question of whether those ORFs are translated was recently addressed by several groups using ribosome profiling. Most of those studies concluded that certain lncRNAs and uORFs are translated, essentially based on computational analysis of ribosome footprints. However, @entity3 remain on the scope of translation and the translational status of individual ORFs. In consequence, further criteria are required to reliably identify translated ORFs from ribosome profiling data. RESULTS: We examined the effect of the translation inhibitors @entity6 , @entity7 and @entity4 on @entity1 @entity2 cell ribosome footprints. We found that @entity6 , a drug that targets eIF4A, allows a far more accurate identification of translated sequences than previously used drugs and computational scoring schemes. Our data show that at least one third but less than two thirds of @entity2 cell lncRNAs are translated. We also identified translated uORFs in hundreds of annotated coding transcripts including key pluripotency transcripts, such as dicer, @entity5 , @entity8 , and ctcf. CONCLUSION: @entity6 inhibition data clearly increase the precision of the detection of translated ORFs in ribosome profiling experiments. Our data show that translation of lncRNAs and uORFs in @entity1 @entity2 cells is rather common although less pervasive than previously suggested. The observation of translated uORFs in several key pluripotency transcripts suggests that translational regulation by uORFs might be part of the network that defines @entity0 stem cell identity.

title: @entity6 -sensitive ribosome profiling reveals the scope of translation in XXXX embryonic stem cells.

answer: @entity1


abstract: BACKGROUND: @entity3 is a common orthopedic problem. Rest, activity modification, and conservative therapies are generally efficacious in relieving symptoms in the majority of @entity0 ; however, a small percentage of @entity0 will experience refractory @entity1 and require surgical intervention to alleviate their discomfort. Surgical release of the common extensor origin can be done through an open, percutaneous, or arthroscopic approach. @entity0 AND METHODS: This prospective study includes 33 @entity0 with chronic resistant @entity3 who had received conservative treatment including modification of activity and 2 injections of 80  mg of @entity2 , for more than 6  months, aiming to compare two different techniques of treatment. The first group included 14 @entity0 with a mean age of 42  years treated by arthroscopic release of common extensor origin. The second group included 19 @entity0 with a mean age of 48  years treated by percutaneous tenotomy. The mean follow up was 12  months for the arthroscopic group and 10  months for the percutaneous tenotomy group. RESULTS: The results were evaluated according to the Disabilities of the Arm, Shoulder and Hand (DASH) score and the visual analogue scale (VAS). In the first group (treated by arthroscopy), the average DASH score improved from 72 to 48 and the average VAS improved from 9.1 to 2. In the second group (treated by percutaneous tenotomy), the average DASH score improved from 70 to 50 and the average VAS improved from 9 to 2.1. Concerning @entity0 satisfaction after surgery, in the first group 7 @entity0 (50%) were pleased, 6 (42.85%) were satisfied and 1 case (7.14%) was not satisfied. In the second group, 7 @entity0 (36.84%) were pleased, 10(52.63%) were satisfied and 2 cases (10.52%) were not satisfied. CONCLUSION: Both arthroscopic and percutaneous release of the common extensor origin can be effective in treatment of @entity3 . Arthroscopic treatment of @entity3 gives more favorable results than percutaneous tenotomy. Although technically more difficult than percutaneous tenotomy, arthroscopy has the advantage of visualization of the pathology and much better improvement of elbow functions.

title: Arthroscopic versus percutaneous release of common extensor origin for treatment of chronic XXXX .

answer: @entity3


abstract: BACKGROUND: Prolonged dual antiplatelet therapy (DAPT) is recommended after an @entity6 ( @entity6 ) to reduce @entity1 events but is associated with increased rates of major and @entity5 . OBJECTIVES: This study sought to determine the incidence of post-percutaneous coronary intervention (PCI) @entity5 that occurs on contemporary DAPT and its impact on quality of life (QOL). METHODS: We studied 9,290 @entity6 @entity0 treated with PCI and discharged alive between April 2010 and September 2012. Post-discharge @entity5 was categorized according to the Bleeding Academic Research Consortium (BARC) definition. The primary outcome was the 6-month @entity7 QOL-5 Dimension (EQ-5D) index score (a measure of health utility); a secondary outcome was the EQ-5D visual analog scale (VAS) at 6 months. RESULTS: Of the 9,290 @entity0 with @entity6 , @entity5 events occurred as follows: any BARC @entity5 : 24.2%; BARC 1: 9.1%; BARC 2: 13.8%; BARC 3: 1.1%; BARC 4: 0.03%; and BARC 5: 0%. Those who experienced any BARC @entity5 had lower scores across all 5 EQ-5D domains (mobility, self-care, usual activities, @entity4 , and @entity3 ), as well as lower EQ-5D VAS and EQ-5D index scores. After clinical risk adjustment, any BARC @entity5 was independently associated with 6-month EQ-5D index score (p  < 0.0001) and lower QOL (p  < 0.001). Both the EQ-5D index and the VAS score declined in a stepwise fashion with increasing BARC severity. CONCLUSIONS: Among @entity0 undergoing PCI for @entity6 , @entity5 during follow-up was associated with worse 6-month utility and QOL. Although even @entity5 was associated with @entity2 status and QOL, the degree of impairment increased in a stepwise fashion with @entity5 severity.

title: Impact of Bleeding on Quality of Life in XXXX on DAPT: Insights From TRANSLATE-ACS.

answer: @entity0


abstract: INTRODUCTION: The correlation between an increased body mass index and @entity1 has been a topical subject matter of literature. The thesis examines whether for @entity0 with @entity1 of the @entity4 the relation between the body cross section and the muscle mass at a particular spot at the abdomen is dislocated toward @entity5 . @entity0 , MATERIALS, AND METHODS: CT examinations of 120 @entity0 with @entity1 have been compared to CTs of 60 @entity2 surgery @entity0 . MEASUREMENTS: In thickness of the layer at the lowest point of the umbilicus the area of the total body cross section and the Mm. psoas majores were determined and their quotient was calculated. Furthermore, the thickness of the M. rectus abdominis and the Mm. obliquii abdominis have been determined at the broadest spot. RESULTS: The reproducibility of the measured data has been extremely high (kappa >0.9). There has been no significant difference in any of the examined parameters between the comparison group and the total @entity0 group. DISCUSSION: According to the literature, @entity0 with @entity1 of the @entity4 on average show a higher body-mass-index (BMI) compared to a comparable group of equivalent age. The height of the umbilicus is a body region, where for adipose @entity0 the amplitude increases markedly, hence for reference measurement appropriate. On the basis of the outcome of this thesis, the most probable explanation for the BMI rise is @entity3 at other body parts.

title: Is XXXX associated with increased muscle mass or adiposity?

answer: @entity1


abstract: @entity2 ( @entity1 ) is the commonest chronic disease in @entity0 . @entity2 and its Impact on Asthma ( @entity4 ) classification based on symptom duration (intermittent vs. persistent) and severity (mild vs. moderate/severe) has not been yet validated in @entity0 . Thus our objective was to validate @entity4 classification in @entity0 , after determining the severity and duration of @entity1 in a pediatric population, using @entity4 definitions. @entity0 aged 6-12 with a diagnosis of @entity1 were included in an observational, cross-sectional, multicenter study. @entity0 were classified according to @entity4 guidelines. AR symptoms were assessed using the Total Four Symptoms Score (T4SS). Severity was also evaluated by the @entity0 using a visual analogue scale (VAS). Comparisons were made by means of a statistical analysis. One thousand two hundred and seventy-five @entity0 from 271 centers were included. Among them, 59.5% had intermittent and 40.5% persistent @entity1 , while 60.7% seasonal and 39.3% perennial according to dated classification, with significant differences existing between one classification and another; 89.7% had moderate/severe @entity3 . Significantly higher T4SS and VAS scores were obtained in moderate/severe compared to mild @entity1 . In our experience, the current @entity4 classification can be considered a valid tool also in @entity0 from 6- to 12-yr old.

title: Validation of XXXX ( @entity2 and its Impact on Asthma) classification in a pediatric population: the PEDRIAL study.

answer: @entity4


abstract: @entity2 ( @entity1 ) is the commonest chronic disease in @entity0 . @entity2 and its Impact on Asthma ( @entity4 ) classification based on symptom duration (intermittent vs. persistent) and severity (mild vs. moderate/severe) has not been yet validated in @entity0 . Thus our objective was to validate @entity4 classification in @entity0 , after determining the severity and duration of @entity1 in a pediatric population, using @entity4 definitions. @entity0 aged 6-12 with a diagnosis of @entity1 were included in an observational, cross-sectional, multicenter study. @entity0 were classified according to @entity4 guidelines. AR symptoms were assessed using the Total Four Symptoms Score (T4SS). Severity was also evaluated by the @entity0 using a visual analogue scale (VAS). Comparisons were made by means of a statistical analysis. One thousand two hundred and seventy-five @entity0 from 271 centers were included. Among them, 59.5% had intermittent and 40.5% persistent @entity1 , while 60.7% seasonal and 39.3% perennial according to dated classification, with significant differences existing between one classification and another; 89.7% had moderate/severe @entity3 . Significantly higher T4SS and VAS scores were obtained in moderate/severe compared to mild @entity1 . In our experience, the current @entity4 classification can be considered a valid tool also in @entity0 from 6- to 12-yr old.

title: Validation of @entity4 ( XXXX and its Impact on Asthma) classification in a pediatric population: the PEDRIAL study.

answer: @entity2


abstract: @entity8 ( @entity8 ) is an @entity11 characterized by progressive @entity9 , @entity3 , and @entity1 . The use of @entity6 ( @entity12 ), a specific inhibitor of vesicular @entity5 transporter, is approved for @entity10 in @entity8 @entity0 . We aimed to review the medical literature concerning the efficacy and tolerability of @entity12 in the treatment of @entity8 @entity0 and to report our personal experience about @entity12 use in a cohort of @entity8 @entity0 . We searched PubMed (1960 to July 2010) using the following keywords: " @entity6 " + " @entity8 + @entity10 ". We included randomized controlled trials, open-label trials, and retrospective studies. We excluded case reports and studies conducted on fewer than 20 @entity0 . In addition, we retrospectively evaluated 2 years' follow-up of @entity12 treatment on motor and cognitive performances and functional abilities in 28 @entity8 @entity0 , compared with 10 @entity0 treated by other neuroleptics ( @entity13 ). Only four papers fulfilled the requested criteria. In the first study, which included 84 randomized outpatients, @entity12 showed a significant improvement of @entity10 compared with placebo. In the open-label study extension, @entity12 confirmed its efficacy on @entity10 , with a frequent occurrence of withdrawals due to side effects. In a retrospective study of long-term efficacy, 63 @entity0 under @entity12 therapy for an average period of 34 months showed a stable effect on @entity10 , despite a slight reduction of effect over time. In a telephone survey conducted on a total of 118 @entity0 affected by different @entity4 , @entity12 showed the most favorable effect for the 28 included @entity8 @entity0 . Our @entity8 @entity0 showed a slight deterioration of motor performances over time that was nonsignificant compared with @entity12 or @entity13 treatments. Despite the fact that the global effect of @entity12 seems positive in @entity8 , more attention on evaluating symptomatic treatments for @entity1 as well as @entity7 would alleviate this @entity2 until a neuroprotective treatment becomes available.

title: Management of XXXX : role of @entity6 .

answer: @entity8


abstract: @entity8 ( @entity8 ) is an @entity11 characterized by progressive @entity9 , @entity3 , and @entity1 . The use of @entity6 ( @entity12 ), a specific inhibitor of vesicular @entity5 transporter, is approved for @entity10 in @entity8 @entity0 . We aimed to review the medical literature concerning the efficacy and tolerability of @entity12 in the treatment of @entity8 @entity0 and to report our personal experience about @entity12 use in a cohort of @entity8 @entity0 . We searched PubMed (1960 to July 2010) using the following keywords: " @entity6 " + " @entity8 + @entity10 ". We included randomized controlled trials, open-label trials, and retrospective studies. We excluded case reports and studies conducted on fewer than 20 @entity0 . In addition, we retrospectively evaluated 2 years' follow-up of @entity12 treatment on motor and cognitive performances and functional abilities in 28 @entity8 @entity0 , compared with 10 @entity0 treated by other neuroleptics ( @entity13 ). Only four papers fulfilled the requested criteria. In the first study, which included 84 randomized outpatients, @entity12 showed a significant improvement of @entity10 compared with placebo. In the open-label study extension, @entity12 confirmed its efficacy on @entity10 , with a frequent occurrence of withdrawals due to side effects. In a retrospective study of long-term efficacy, 63 @entity0 under @entity12 therapy for an average period of 34 months showed a stable effect on @entity10 , despite a slight reduction of effect over time. In a telephone survey conducted on a total of 118 @entity0 affected by different @entity4 , @entity12 showed the most favorable effect for the 28 included @entity8 @entity0 . Our @entity8 @entity0 showed a slight deterioration of motor performances over time that was nonsignificant compared with @entity12 or @entity13 treatments. Despite the fact that the global effect of @entity12 seems positive in @entity8 , more attention on evaluating symptomatic treatments for @entity1 as well as @entity7 would alleviate this @entity2 until a neuroprotective treatment becomes available.

title: Management of @entity8 : role of XXXX .

answer: @entity6


abstract: Th17 cells have emerged as a key factor in the pathogenesis of @entity6 as well as other @entity4 . They secrete a number of cytokines including @entity10 , @entity11 and @entity15 and until now the effects of these cytokines on resident cells of the eye were not yet clear. The purpose of this study was to investigate the effects of Interleukin (IL)-17A, @entity11 and @entity15 on the production of inflammatory mediators and barrier function of @entity5 cells. We showed that @entity0 cells, a spontaneously arisen cell line of @entity5 ( @entity5 ), constitutively expressed @entity16 and @entity14 , but not @entity18 . @entity10 significantly enhanced the production of @entity3 , @entity9 , @entity17 and @entity2 by these cells. @entity11 had a similar effect on the production of @entity3 , @entity9 and @entity2 by @entity0 cells, but did not influence the expression of @entity17 . Both @entity10 and @entity11 significantly decreased the transepithelial electrical resistance (TER) of the ARPE-19 monolayer and increased the diffusion rate of @entity7 ( @entity8 )-dextran. They also disrupted the distribution of the junction proteins @entity13 and @entity12 at the interface of adjacent cells. @entity15 did not have a detectable effect on the production of the tested inflammatory mediators by @entity0 cells, TER of the ARPE-19 monolayer, the diffusion rate of @entity8 -dextran or the distribution of @entity19 . This study demonstrates that @entity10 and @entity11 , but not @entity15 , significantly promoted @entity0 cells to secrete inflammatory mediators and compromised the ARPE-19 monolayer barrier function in association with a disrupted distribution of @entity19 . These results suggest that both @entity10 and @entity11 may play a role in @entity1 of the eye.

title: The effects of Th17 cytokines on the inflammatory mediator production and barrier function of XXXX cells.

answer: @entity0


abstract: BACKGROUND: In order to fight digestive parasitism in Tunisia, a national program of surveillance of non-permanent resident students in Tunisia has been found to detect these @entity3 in this target population. OBJECTIVE: To determine the prevalence of @entity1 among non-permanent resident students in Tunisia, to identify the different parasitic species founded and to show the interest of this screening. METHODS: During a period of 23 years (1990-2012), 7386 parasitological examinations of stools has been made among students essentially from or had visited tropical Africa, Maghreb and Middle-East, at the laboratory of Parasitology-Mycology at the Rabta Hospital of Tunis. RESULTS: The prevalence of @entity4 found was 34.45% (i.e. 2545 infested students). Among the protozoa that have been isolated in the majority of cases (78.75%), amoebae were most frequently found (86.4%) represented mainly by Entamoeba coli and Endolimax nanus in respectively, 25.62 and 23.33% of parasites isolated; while @entity2 /dispar, only pathogenic Amoeba was found in 8.05% of the total of parasites isolated. Regarding helminths, found in 21.25% of parasites isolated, Ankylostome was predominant (34.5%) represented by the species of @entity5 . A single case of Ancylostom duodenale has been isolated. Among the identified parasite species, 38.7% were known parasitic pathogens for @entity0 . CONCLUSIONS: These results note the interest of the control of the non-permanent resident students in Tunisia. The precocious tracking and treatment of affected subjects permits to avoid the introduction and the dissemination of parasites already rare and virulent strains in our country.

title: Intestinal XXXX among non-permanent resident students in tunisia: a review of 23 years of monitoring in the department of Parasitology-mycology at the rabta hospital of tunis.

answer: @entity3


abstract: OBJECTIVE: To evaluate the clinical effects of dynamic neutralization system (K-Rod) in treating @entity1 . METHODS: From October 2011 to October 2013, 20 @entity0 with @entity1 were treated with dynamic neutralization system (K-Rod). There were 8 males and 12 females with an average age of 45.4 years old (ranged from 31 to 65) and an average course of 3.8 years (ranged from 9 months to 6.25 years). All @entity0 had the history of @entity4 . Among them, 10 cases were far @entity3 , 7 cases were @entity5 , 3 cases were lumbar spondylolisthesis (degree I in 2 cases and degree II in 1 case). Every @entity0 had only one responsible segment which causing the symptom would have to be rigidly fixed during operations, and the adjacent intervertebral disc of the responsible segments at least 1 segment has already obvious degenerated. All @entity0 underwent the operation to relieve compressed nerves and reconstruct spinal stability with K-Rod system (the responsible segments were fixed with interbody fusion, and the adjacent segments were fixed with dynamic stabilization). Visual analogue scale (VAS), Japanese Orthopaedic Association Scores (JOA) and @entity2 Index (ODI) were used to evaluate the clinical effects. Imaging data were used to analyze the range of motion (ROM), intervertebral disc height and intervertebral disc signal (according to modified Pfirrmann grading system) in degenerative adjacent segment. RESULTS: All @entity0 were followed up for more than 1 year, and preoperative symptoms obviously relieved. There were significant differences in VAS, JOA, ODI between preoperative and postoperative (postoperative at 1 week and 1 year) (P<0.05). Radiological examination showed that all responsible segments had already fused, and no looseness, displacement and breakage of internal fixations were found. Postoperative at 1 year, the ROM of adjacent segments were decreased (P<0.05). There was no significant difference in intervertebral disc height between preoperative and postoperative at 1 year (P>0.05). According to modified Pfirrmann grading system to classification for the 25 disks of adjacent segment, 8 disks (32%) got improvement, 15 disks (60%) got no change and 2 disks (8%) got aggravation at 1 year after operation. CONCLUSION: Dynamic neutralization system (K-Rod) combined with interbody fusion could obtain short-term clinical effects in the treatment of @entity1 .

title: [Clinical application of dynamic neutralization system (K-Rod) in treating XXXX ].

answer: @entity1


abstract: BACKGROUND: The long-term significance of @entity9 ( @entity9 ) has not been thoroughly studied. OBJECTIVES: To evaluate, at age 5 years, the health status of consecutive @entity0 diagnosed with @entity9 in infancy. METHODS: Based on the diagnostic workup, @entity0 were classified into two groups: a 'broad' evaluation group (at least one test/procedure related to each of the five main causes: infectious, metabolic, cardiopulmonary, gastroenterological, neurological), and a 'narrow' workup group whose evaluation did not cover all five domains. Health status around age 5 was obtained from hospital records, community clinics and parents/caregivers. RESULTS: We identified 132 @entity0 with @entity9 . @entity8 (49.2%) was the most common description, followed by @entity5 (13.6%), suspected @entity6 (12.9%), @entity7 (12.1%), breath-holding spell (8.3%), and pallor (3.8%). A broad diagnostic workup was performed in 62.1% of the @entity0 , and a narrow workup in 37.9%. At age 5 years, 56.8% of the @entity0 were healthy; 27.3% reported chronic conditions unrelated to @entity9 . Twenty-one @entity0 (15.9%) had unrelated @entity3 , mostly @entity2 . One of the 132 @entity9 @entity0 relapsed and was eventually diagnosed with @entity4 . CONCLUSIONS: A single episode of @entity9 in infancy was neither predictive of nor associated with chronic systemic or @entity1 at age 5 years.

title: Apparent Life-Threatening Events: XXXX ' Health Status at 5 Years of Age.

answer: @entity0


abstract: OBJECTIVE: Endometrial biopsy score is an accepted marker of uterine health and predicted fertility, and it has been suggested that endometrial alternations are correlated with susceptibility to persistent @entity3 . The objective of this study was to investigate associations of endometrial biopsy score with: 1) presence of polymorphonuclear cells (PMNs) in the epithelium and stratum compactum in histopathology; 2) presence of PMNs in cytology and 3) presence of @entity1 in microbiology. MATERIALS AND METHODS: The material for examination was collected from 69 mares suspected for subclinical @entity3 (bred three or more times unsuccessfully in the same breeding season) and from 15 maiden mares. Samples were collected by endometrial biopsy and cytobrush technique. RESULTS: Endometrial alterations (biopsy score IIA, IIB, III) were found in 64 of 82 mares (78%). There was an increase in PMN occurrence for grades IIA, IIB and III. When comparing grades and PMNs infiltration, we observed statistically significant differences between grades I and IIA (p = 0.222) and grades I and IIB (p  =  0.042) in samples collected by endometrial biopsy. Statistically significant differences were found in microbiological examination (biopsy p  =  0.036; cytobrush p  = 0.189), cytological examination (biopsy p  =  0.040; cytobrush p  =  0.079) and PMN infiltration (p=0.042) between mares with biopsy scores I and IIB. Furthermore, the highest percentage of infected mares was in grade IIA and IIB, and we found statistically significant differences between grades I and IIA (p  =  0.043), and grades I and IIB (p  =  0.036) in biopsy samples. We observed a tendency to higher prevalence of @entity2 in mares with biopsy score IIA, IIB and III than with biopsy score I in samples collected using cytobrush technique. However, there were no statistical significant differences. CONCLUSION: Degenerative endometrial changes can predispose to uterine @entity1 and @entity0 . Our study shows that mares with endometrial score I are less predisposed to @entity1 than mares with category IIA, IIB and III. Endometrial biopsy is a reliable diagnostic tool.

title: Relationship between uterine biopsy score, XXXX and @entity0 .

answer: @entity2


abstract: OBJECTIVE: Endometrial biopsy score is an accepted marker of uterine health and predicted fertility, and it has been suggested that endometrial alternations are correlated with susceptibility to persistent @entity3 . The objective of this study was to investigate associations of endometrial biopsy score with: 1) presence of polymorphonuclear cells (PMNs) in the epithelium and stratum compactum in histopathology; 2) presence of PMNs in cytology and 3) presence of @entity1 in microbiology. MATERIALS AND METHODS: The material for examination was collected from 69 mares suspected for subclinical @entity3 (bred three or more times unsuccessfully in the same breeding season) and from 15 maiden mares. Samples were collected by endometrial biopsy and cytobrush technique. RESULTS: Endometrial alterations (biopsy score IIA, IIB, III) were found in 64 of 82 mares (78%). There was an increase in PMN occurrence for grades IIA, IIB and III. When comparing grades and PMNs infiltration, we observed statistically significant differences between grades I and IIA (p = 0.222) and grades I and IIB (p  =  0.042) in samples collected by endometrial biopsy. Statistically significant differences were found in microbiological examination (biopsy p  =  0.036; cytobrush p  = 0.189), cytological examination (biopsy p  =  0.040; cytobrush p  =  0.079) and PMN infiltration (p=0.042) between mares with biopsy scores I and IIB. Furthermore, the highest percentage of infected mares was in grade IIA and IIB, and we found statistically significant differences between grades I and IIA (p  =  0.043), and grades I and IIB (p  =  0.036) in biopsy samples. We observed a tendency to higher prevalence of @entity2 in mares with biopsy score IIA, IIB and III than with biopsy score I in samples collected using cytobrush technique. However, there were no statistical significant differences. CONCLUSION: Degenerative endometrial changes can predispose to uterine @entity1 and @entity0 . Our study shows that mares with endometrial score I are less predisposed to @entity1 than mares with category IIA, IIB and III. Endometrial biopsy is a reliable diagnostic tool.

title: Relationship between uterine biopsy score, @entity2 and XXXX .

answer: @entity0


abstract: BACKGROUND: Eosinophils are the key inflammatory cells in @entity2 , and more and more evidence suggests their crucial role in exercise-induced bronchoconstriction (EIB). Eotaxin, as the most important chemotactic factor for eosinophils, plays an important role in the pathogenesis of @entity2 . OBJECTIVES: The aim of the study was to evaluate the changes in eotaxin levels in exhaled breath condensate (EBC) following intensive exercise in allergic asthmatics. METHODS: The study was performed in a group of 27 asthmatics (17 with EIB, 13 without EIB) and 9 healthy volunteers. Changes induced by intensive exercise in the concentrations of eotaxin in EBC during the 24 h after an exercise test were assessed. The possible correlations of these measurements with the results of other tests commonly associated with @entity1 were also determined. RESULTS: In @entity3 @entity0 with EIB, a statistically significant increase in eotaxin concentrations in EBC collected during the first 24 h after an exercise test - with maximal increase after 6 h - was revealed. A statistically significant correlation between the maximum increase in eotaxin concentrations in EBC after exercise, and an increase in either serum eosinophil cationic protein or F(ENO) 24 h after exercise in the group of asthmatics with EIB, was observed. CONCLUSIONS: Our results confirm connections between EIB and airway eosinophilic @entity1 . The increase of eotaxin in @entity3 airways, by promoting the migration and activation of eosinophils, may play an important role in upregulation and sustaining of the airway @entity1 observed in EIB in @entity3 @entity0 .

title: Eotaxin in exhaled breath condensate of allergic asthma XXXX with exercise-induced bronchoconstriction.

answer: @entity0


abstract: OBJECTIVES: @entity2 use is a risk factor for the development and progression of @entity1 . The purpose of this study was to determine the correlation between smoking status among @entity0 and their compliance with @entity1 screening guidelines. MATERIALS AND METHODS: A cross-sectional analysis of the Behavioral Risk Factor Surveillance System was performed using the 2006 survey data. @entity0 with no history of hysterectomy who answered the questions regarding smoking status, age, and last @entity3 smear were included (n = 150,786). Data were weighted for survey design. RESULTS: The overall prevalence of compliance with @entity1 screening guidelines was 83.9%. The rate of compliance was highest among former smokers (86.7%) compared with never smokers (83.7%) and current smokers (81.7%; p < .001). Among @entity0 aged 21 to 65 years, the odds of current smokers having had a @entity3 test in the past 3 years was 0.70 compared with @entity0 who never smoked (95% confidence interval = 0.63-0.77), when controlled for marital status, income, and access to health care. The odds of former smokers complying with screening guidelines were similar to @entity0 who never smoked. CONCLUSIONS: @entity0 who smoke are at higher risk for developing @entity1 but have a lower rate of screening for the disease. Efforts to increase prevalence of @entity3 test compliance should target current smokers.

title: Correlation between smoking status and XXXX screening: a cross-sectional study.

answer: @entity1


abstract: UNASSIGNED: Action mechanisms of anesthetics remain unclear because of difficulty in explaining how structurally different anesthetics cause similar effects. In @entity0 , local anesthetics and antipsychotic @entity3 induced responses similar to those caused by @entity1 starvation, and they eventually inhibited cell growth. These drugs inhibited @entity1 uptake but additional @entity1 conferred resistance to their effects; hence, the primary action of the drugs is to cause @entity1 starvation. In hxt(0) strains with all @entity4 transporter (HXT) genes deleted, a strain harboring a single copy of @entity5 ( @entity5 ) was more sensitive to @entity2 than a strain harboring multiple copies (HXT1m), which indicates that quantitative reduction of @entity5 increases @entity2 sensitivity. However, additional @entity1 rather than the overexpression of @entity6 conferred @entity2 resistance to wild-type @entity0 ; therefore, Hxts that actively transport hexoses apparently confer @entity2 resistance. Additional @entity1 alleviated sensitivity to local anesthetics and @entity3 in the HXT1m strain but not @entity5 s strain; thus, the @entity1 -induced effects required a certain amount of @entity5 . At low concentrations, fluorescent @entity3 were distributed in various membranes. At higher concentrations, they destroyed the membranes and thereby delocalized @entity5 -GFP from the plasma membrane, similar to local anesthetics. These results suggest that the aforementioned drugs affect various membrane targets via nonspecific interactions with membranes. However, the drugs preferentially inhibit the function of abundant Hxts, resulting in @entity1 starvation. When Hxts are scarce, this preference is lost, thereby losing the alleviation by additional @entity1 . These results provide a mechanism that explains how different compounds induce similar effects according to lipid theory.

title: Local Anesthetics and Antipsychotic XXXX Interact Nonspecifically with Membranes and Inhibit Hexose Transporters in @entity0 .

answer: @entity3


abstract: UNASSIGNED: Action mechanisms of anesthetics remain unclear because of difficulty in explaining how structurally different anesthetics cause similar effects. In @entity0 , local anesthetics and antipsychotic @entity3 induced responses similar to those caused by @entity1 starvation, and they eventually inhibited cell growth. These drugs inhibited @entity1 uptake but additional @entity1 conferred resistance to their effects; hence, the primary action of the drugs is to cause @entity1 starvation. In hxt(0) strains with all @entity4 transporter (HXT) genes deleted, a strain harboring a single copy of @entity5 ( @entity5 ) was more sensitive to @entity2 than a strain harboring multiple copies (HXT1m), which indicates that quantitative reduction of @entity5 increases @entity2 sensitivity. However, additional @entity1 rather than the overexpression of @entity6 conferred @entity2 resistance to wild-type @entity0 ; therefore, Hxts that actively transport hexoses apparently confer @entity2 resistance. Additional @entity1 alleviated sensitivity to local anesthetics and @entity3 in the HXT1m strain but not @entity5 s strain; thus, the @entity1 -induced effects required a certain amount of @entity5 . At low concentrations, fluorescent @entity3 were distributed in various membranes. At higher concentrations, they destroyed the membranes and thereby delocalized @entity5 -GFP from the plasma membrane, similar to local anesthetics. These results suggest that the aforementioned drugs affect various membrane targets via nonspecific interactions with membranes. However, the drugs preferentially inhibit the function of abundant Hxts, resulting in @entity1 starvation. When Hxts are scarce, this preference is lost, thereby losing the alleviation by additional @entity1 . These results provide a mechanism that explains how different compounds induce similar effects according to lipid theory.

title: Local Anesthetics and Antipsychotic @entity3 Interact Nonspecifically with Membranes and Inhibit Hexose Transporters in XXXX .

answer: @entity0


abstract: CONTEXT: Argemone mexicana L. is native to Mexico and the plant extracts are used in traditional medicine in India and South American countries. Argemone oil (AO) is a common adulterant of mustard oil in India and causes serious pathophysiological consequences leading to outbreaks of @entity0 among consumers. In vivo cytogenetic studies on the toxicological effects of AO and its component alkaloids are limited. OBJECTIVE: The present study was undertaken to evaluate the safety of AO by assessment of their in vivo genotoxic potential in bone marrow cells of @entity1 . MATERIALS AND METHODS: AO mixed in @entity3 oil in the proportions of 0.01, 0.1, and 1   ml AO/kg body weight in a total volume of 10   ml/kg body weight and a single undiluted dose of AO (10   ml/kg body weight) were administered intraperitoneally in separate groups of male Swiss Albino @entity1 for 24   h. In addition, a single concentration of @entity4 (SG) (50   mg/kg body weight) was also administered. Genotoxicity was evaluated by chromosome aberration (CA) and sister chromatid exchange (SCE) tests. @entity2 ( @entity2 ) differential technique was used to study the effect on cell replication by the calculation of average generation time (AGT). RESULTS: The minimum effective concentrations that produced significant frequencies of CA and SCE were 0.1 and 0.01   ml/kg, respectively. AO and SG induced an insignificant increase of AGT indicating that they are non-cytotoxic in the concentrations tested. DISCUSSION AND CONCLUSION: Our results confirm that AO is genotoxic even at low concentrations and its usage should be checked.

title: Argemone oil induces genotoxicity in XXXX .

answer: @entity1


abstract: OBJECTIVES: To evaluate the effectiveness and comparative effectiveness of treatments for @entity0 with @entity11 ( @entity11 ) and bariatric surgery @entity0 and @entity0 with loss-of-control (LOC) eating. Studies of @entity11 therapies include pharmacological interventions, psychological and behavioral interventions, or combinations of approaches. We examined whether treatment effectiveness differed in @entity0 subgroups and described @entity5 for @entity11 and LOC eating. DATA SOURCES: We searched MEDLINE(  ), EMBASE(  ), the Cochrane Library, Academic OneFile, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) through January 19, 2015. Eligible studies included randomized controlled trials (RCTs), nonrandomized trials, meta-analyses, and, for @entity5 , cohort and case-control studies. REVIEW METHODS: Pairs of reviewers independently selected, extracted data from, and rated the risk of bias of relevant studies; they graded the strength of evidence using established criteria. We conducted meta-analysis for some treatment outcomes. RESULTS: Of 52 included RCTs of treatment; 48 concerned @entity11 therapy. Course-of- @entity5 evidence came from 15 observational studies. We examined four major outcomes: binge eating and abstinence, eating-related psychopathology, weight, and general psychological and other outcomes. Second-generation antidepressants (as a class), @entity8 (an anticonvulsant), and @entity13 (a stimulant) were superior to placebo in achieving abstinence and reducing binge episodes and/or binge days and eating-related obsessions and @entity9 . Second-generation antidepressants decreased @entity6 . @entity8 and @entity13 produced @entity7 in study populations whose members were virtually all overweight or @entity4 . A few formats of cognitive behavioral therapy (CBT)   therapist led, partially therapist led, and guided self-help   were superior to placebo in achieving abstinence and reducing binge frequency. CBT for @entity11 was generally ineffective for reducing weight or @entity6 in this population. Therapist-led CBT was not superior to either partially therapist-led CBT or structured self-help CBT for @entity12 and weight outcomes. Behavioral weight loss treatment produced greater weight loss than CBT at the end of treatment but not over the longer run. @entity8 , @entity10 , and @entity13 were associated with @entity3 , including @entity2 ; @entity8 and @entity13 were associated with sympathetic nervous system arousal and @entity1 . We found no evidence on bariatric surgery @entity0 . Treatments for LOC eating in @entity0 did not achieve superior @entity7 outcomes. Evidence on the course of either @entity5 was limited. Early adolescent @entity11 and LOC eating predicts such behaviors in the future. CONCLUSIONS: @entity11 @entity0 may benefit from treatment with second-generation antidepressants, @entity13 , @entity8 , and CBT. Additional studies should address other treatments, combinations of treatment, and comparisons between treatments; treatment for postbariatric surgery @entity0 and @entity0 ; and the course of these illnesses.

title: Management and Outcomes of XXXX

answer: @entity11


abstract: 1. The subunits alpha and beta of @entity6 DNA-dependent RNA polymerase have been purified to electrophoretic homogeneity. Both have mol.wt. 18000 and they are required in equimolar amounts for optimum activity. 2. The instability of the complete enzyme, alphabeta, in the absence of salt is due to the rapid inactivation of the beta subunit in these conditions. 3. Nearest-neighbour analysis of the product formed on poly[d( @entity3 )] as template shows that the enzyme copies the latter accurately. 4. The enzyme initiates new chains with purine @entity5 exclusively. 5. The product obtained in the standard assay conditions contains some high mol.wt. (>16S) material, but consists primarily of short chains, of average length 70-80 @entity0 units. 6. The template specificity of the complete enzyme has been studied at high and low ionic strength. Its extreme dependence on salt concentration is unrelated to the gross overall base composition of the DNA used. 7. T(7) DNA is transcribed asymmetrically and the enzyme selectively copies the T(7) ;early' genes. 8. Preliminary @entity2 analyses of alpha and beta subunits show that their overall content of acidic, basic and neutral @entity4 does not differ appreciably from that of @entity1 RNA polymerase.

title: Isolation and properties of highly purified XXXX deoxyribonucleic acid-dependent ribonucleic acid polymerase.

answer: @entity6


abstract: The aim of this study was to identify the @entity2 on @entity5 ( @entity5 ) in @entity0 with @entity4 ( @entity4 ) and to examine the relationship with the duration of disease and pulmonary function test (PFT) results. Twenty male @entity4 @entity0 with a mean age of 37.1    9.4 years were enrolled in this study. The @entity0 were assigned into 2 groups according to disease duration: @entity0 with disease duration <10 years (n = 10) and >=  10 years (n = 10). All @entity0 underwent clinical examination, @entity8 and @entity5 . @entity5 revealed @entity3 @entity0 (70%). The most common findings were apical @entity1 (45%) and @entity6 (25%). @entity5 findings were more prominent in late @entity4 @entity0 (disease duration >=  10 years) (P = 0.015). PFT were considered as abnormal in 4 @entity0 (20%). While 3 @entity0 had a restrictive type @entity2 , one @entity0 had a mild obstructive pattern. Three of these @entity0 had concomitant @entity7 . On the other hand, 10 @entity0 with normal PFT had abnormalities on @entity5 . These findings suggest that @entity2 in @entity4 @entity0 without respiratory symptoms could be sensitively detected by @entity5 . However, the clinical significance of these @entity3 should be examined in further prospective studies.

title: @entity2 on @entity5 in XXXX : relationship to disease duration and pulmonary function testing.

answer: @entity4


abstract: The aim of this study was to identify the @entity2 on @entity5 ( @entity5 ) in @entity0 with @entity4 ( @entity4 ) and to examine the relationship with the duration of disease and pulmonary function test (PFT) results. Twenty male @entity4 @entity0 with a mean age of 37.1    9.4 years were enrolled in this study. The @entity0 were assigned into 2 groups according to disease duration: @entity0 with disease duration <10 years (n = 10) and >=  10 years (n = 10). All @entity0 underwent clinical examination, @entity8 and @entity5 . @entity5 revealed @entity3 @entity0 (70%). The most common findings were apical @entity1 (45%) and @entity6 (25%). @entity5 findings were more prominent in late @entity4 @entity0 (disease duration >=  10 years) (P = 0.015). PFT were considered as abnormal in 4 @entity0 (20%). While 3 @entity0 had a restrictive type @entity2 , one @entity0 had a mild obstructive pattern. Three of these @entity0 had concomitant @entity7 . On the other hand, 10 @entity0 with normal PFT had abnormalities on @entity5 . These findings suggest that @entity2 in @entity4 @entity0 without respiratory symptoms could be sensitively detected by @entity5 . However, the clinical significance of these @entity3 should be examined in further prospective studies.

title: XXXX on @entity5 in @entity4 : relationship to disease duration and pulmonary function testing.

answer: @entity2


abstract: The aim of this study was to identify the @entity2 on @entity5 ( @entity5 ) in @entity0 with @entity4 ( @entity4 ) and to examine the relationship with the duration of disease and pulmonary function test (PFT) results. Twenty male @entity4 @entity0 with a mean age of 37.1    9.4 years were enrolled in this study. The @entity0 were assigned into 2 groups according to disease duration: @entity0 with disease duration <10 years (n = 10) and >=  10 years (n = 10). All @entity0 underwent clinical examination, @entity8 and @entity5 . @entity5 revealed @entity3 @entity0 (70%). The most common findings were apical @entity1 (45%) and @entity6 (25%). @entity5 findings were more prominent in late @entity4 @entity0 (disease duration >=  10 years) (P = 0.015). PFT were considered as abnormal in 4 @entity0 (20%). While 3 @entity0 had a restrictive type @entity2 , one @entity0 had a mild obstructive pattern. Three of these @entity0 had concomitant @entity7 . On the other hand, 10 @entity0 with normal PFT had abnormalities on @entity5 . These findings suggest that @entity2 in @entity4 @entity0 without respiratory symptoms could be sensitively detected by @entity5 . However, the clinical significance of these @entity3 should be examined in further prospective studies.

title: @entity2 on XXXX in @entity4 : relationship to disease duration and pulmonary function testing.

answer: @entity5


abstract: @entity0 with @entity2 and @entity4 have been reported to respond poorly to sacral neuromodulation. We report on our experience in treating voiding symptoms with sacral neuromodulation after spinal surgery. The medical charts of @entity0 evaluated for sacral neuromodulation from 2000-2008 were retrospectively reviewed. Indications, need for explantation, and clinical success (>50% symptom improvement) were recorded. The cohort of @entity0 who had undergone prior spinal surgery was compared to @entity0 with no history of spinal surgery or @entity1 . Thirty-two @entity0 with a history of spinal surgery and 136 with no history of @entity1 underwent sacral neuromodulation testing. Twenty @entity0 and @entity0 (62.5%) from the spinal surgery group ultimately underwent permanent implantation. Seventeen of the 32 @entity0 were diagnosed with urge @entity3 , of whom 52.9% reported a successful outcome at a mean of 2.3 years of follow-up, compared to an 80.3% success rate in @entity0 with no history of spinal surgery (p=0.018). Sixteen of 32 carried a diagnosis of urgency/frequency with 62.5% success at last follow-up, compared 73.9% (p=0.35) of those without a history of spinal surgery or @entity1 . Thirteen of 32 @entity0 diagnosed with urinary retention experienced a 61.5% long-term success rate, compared with 63.6% for those without spinal surgery and urinary retention. Six of 20 (30.0%) in the spinal surgery group were explanted at a mean time of 2.9 years, compared with 27 of 102 (26.5%) of the non-neurologic @entity0 . Clinical success can be achieved using sacral neuromodulation in @entity0 with @entity4 and a history of spinal surgery; however, those with urge @entity3 are less likely to report significant improvement.

title: Sacral neuromodulation for refractory urge XXXX is less effective following spinal surgery.

answer: @entity3


abstract: BACKGROUND: Controversy exists regarding the best treatment of @entity2 in the elderly. Recent studies of open reduction and internal fixation have demonstrated high complication rates. QUESTIONS/PURPOSES: We asked whether (1) open reduction and internal fixation could be performed with low rates of immediate and delayed complications, (2) reduction of these @entity2 could be maintained over time by evaluating long-term radiographs and visual analog @entity1 scores, and (3) 6-week immobilization would lead to disabling @entity5 by evaluating postoperative motion and functional scores. @entity0 AND METHODS: We retrospectively reviewed all 35 @entity0 older than 75  years with displaced @entity2 treated using a "hybrid" technique between 2002 and 2008. All @entity0 were immobilized for 6  weeks after surgery. Thirteen of the 35 @entity0 either died or developed severe @entity3 during followup. The analysis included 22 @entity0 followed a minimum of 1  year (mean, 3  years; range, 1-6.7  years). RESULTS: There were no early or late reoperations in this series. An acceptable reduction was achieved in 89% of the shoulders and maintained over time. All @entity2 healed. @entity4 was noted on radiographs in 11% of the shoulders. Six weeks of immobilization did not lead to disabling @entity5 . At most recent followup, mean active elevation was 141  , mean active internal rotation L1, mean active external rotation 36  , and mean American Society of Shoulder and Elbow Surgeons score 68. CONCLUSIONS: Utilizing this approach, open reduction and internal fixation followed by 6-week immobilization results in a low rate of reoperation and good functional outcomes for elderly @entity0 with @entity2 . LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

title: XXXX in the elderly can be reliably fixed with a "hybrid" locked-plating technique.

answer: @entity2


abstract: BACKGROUND: The unavailability of an effective and long-lasting treatment for sacroiliac-based @entity1 has led researchers to study the efficacy of radiofrequency in denervation. In this study, we aimed to investigate the efficacy and safety of novel cooled radiofrequency application for sacral lateral-branch denervation. METHODS: @entity0 experiencing chronic @entity1 were selected for our observational study. Fluoroscopy guidance cooled radiofrequency denervation was applied on the L5 dorsal ramus and the @entity3 lateral branches on @entity0 who had twice undergone consecutive joint blockages to confirm the diagnosis and obtained at least 75% @entity1 relief. At the 1st, 3rd and 6th month postoperatively, the @entity0 ' @entity1 was evaluated using a visual analog scale (VAS), and their physical function was evaluated with the @entity2 Index (ODI). RESULTS: Cooled radiofrequency was applied on a total of 15 @entity0 . Prior to the procedures, the median VAS score (interquartile range) was 8 (7-9), but at the 1st, 3rd and 6th month, this had fallen to 3 (1-4), 2 (1-3) and 3 (2-4). The baseline median ODI score (interquartile range) was 36 (32-38), while at the 1st, 3rd and 6th month, it was 16 (8-20), 12 (9-18) and 14 (10-20), respectively. At the final control, while 80% of the @entity0 reported at least a 50% decline in @entity1 scores, 86.7% of those reported at least a ten-point reduction in ODI scores. CONCLUSION: It was seen that the cooled radiofrequency used for sacroiliac denervation was an effective and safe method in the short to intermediate term.

title: Cooled radiofrequency application for treatment of XXXX .

answer: @entity1


abstract: PURPOSE: We evaluated the effectiveness of an early POI in newly diagnosed @entity1 @entity0 in reducing the occurrence of @entity2 disturbances. METHODS: We designed a mono-institutional prospective study involving all new @entity0 admitted to the Oncology Department of Fatebenefratelli and Ophtalmic Hospital in Milan from January 2005 until September 2008. During the first visit, the oncologist could offer support with a psycho-oncologist. The @entity0 who accepted had a first interview (T0), during which they took a self-evaluation test (HADS, @entity3 and @entity4 scale). On the basis of the score, the psycho-oncologist could offer psychotherapy and/or pharmacological intervention, if necessary. At the end of the eight sessions (T1), the @entity0 repeated the self-evaluation test with the HADS, and we analysed both the difference in the HADS score between T0 and T1 and the clinical evaluation of the psycho-oncologist. RESULTS: Three hundred eighteen @entity0 were evaluated with a psychoanalytical psychotherapy approach by two psycho-oncologists through a first interview and 90 of them were eligible for the present study also for the evaluation of HADS. The average HADS score in T0 was 15.26 for @entity4 (sd=3.21) and 13.86 for @entity3 (sd   =   2.05). The reassessment at the end of the psychotherapy (T1) showed an average HADS score of 5.94 for @entity4 (sd   =   3.11) and 6.58 for @entity3 (sd   =   2.88). Only five @entity0 were treated with a pharmacological approach alone. CONCLUSIONS: Considering all the limits of our study, we may conclude that an early POI significantly reduces @entity0 ' @entity2 symptoms and the risk of a negative evolution of pathological situations in those @entity0 who are motivated and express a need for psychological help.

title: A mono-institutional prospective study on the effectiveness of a specialist psychotherapeutic intervention (POI) started at the diagnosis of XXXX .

answer: @entity1


abstract: OBJECTIVE: To assess if pulmonary CT angiography (CTA) can predict outcome in @entity0 with @entity2 ( @entity2 ). METHODS: Retrospective analysis of CTA studies of @entity0 with @entity2 and documentation of pulmonary artery (PA)/aorta ratio, right ventricular (RV)/left ventricular (LV) ratio, superior vena cava ( @entity3 ) diameter, pulmonary obstruction index (POI), ventricular septal bowing (VSB), venous contrast reflux (VCR), @entity4 and @entity1 . Furthermore, duration of total hospital stay, necessity for/duration of ICU therapy, necessity for mechanical ventilation and mortality were recorded. Comparison was performed by logistic/linear regression analysis with significance at 5%. RESULTS: 152 @entity0 were investigated. Mean duration of hospital stay was 21          24 days. 66 @entity0 were admitted to the ICU; 20 received mechanical ventilation. Mean duration of ICU therapy was 3          8 days. Mortality rate was 8%. Significant positive associations of POI, VCR and @entity4 with necessity for ICU therapy were shown. VCR was significantly associated with necessity for mechanical ventilation and duration of ICU treatment. Pleural effusions were significantly associated with duration of total hospital stay whereas the RV/LV ratio correlated with mortality. CONCLUSION: Selected CTA findings showed significant associations with the clinical course of @entity2 and may thus be used as predictive parameters.

title: Multidetector-CT angiography in XXXX -can image parameters predict clinical outcome?

answer: @entity2


abstract: OBJECTIVE: To conduct a dose testing analysis of @entity4 microbubble ( @entity5 ) @entity3 ( @entity3 ) to determine the optimal dose for detection of liver @entity1 in @entity0 with extra-hepatic primary @entity2 . METHODS: 157 @entity0 were investigated with conventional US and @entity3 . @entity3 was performed following intravenous administration of @entity4 microbubbles (using one dose of either 0.008, 0.08, 0.12 or 0.36  L/kg body weight). Three blinded off-site readers recorded the number and locations of metastatic lesions detected by US and @entity3 . Contrast enhanced CT and MRI were used as the "Standard Of Reference" (SOR). Sensitivity, specificity and accuracy of liver @entity1 detection with US versus @entity3 , for each dose group were obtained. Dose group analysis was performed using the Chi-square test. RESULTS: 165 @entity1 were present in 92 @entity0 who each had 1-7 lesions present on the SOR. Sensitivity of US versus @entity3 (for all doses combined) was 38% and 67% (p   =   0.0001). The 0.12 dose group with @entity3 (78%) had significantly higher sensitivity and accuracy (70%) compared to other dose groups (p   <   0.05). CONCLUSION: The diagnostic performance of @entity3 is dose dependent with the 0.12  L/kg @entity5 dose group showing the greatest sensitivity and accuracy in detection of liver @entity1 .

title: Contrast enhanced ultrasound in the detection of liver XXXX : a prospective multi-centre dose testing study using a @entity4 microbubble contrast agent ( @entity5 ).

answer: @entity1


abstract: OBJECTIVE: To conduct a dose testing analysis of @entity4 microbubble ( @entity5 ) @entity3 ( @entity3 ) to determine the optimal dose for detection of liver @entity1 in @entity0 with extra-hepatic primary @entity2 . METHODS: 157 @entity0 were investigated with conventional US and @entity3 . @entity3 was performed following intravenous administration of @entity4 microbubbles (using one dose of either 0.008, 0.08, 0.12 or 0.36  L/kg body weight). Three blinded off-site readers recorded the number and locations of metastatic lesions detected by US and @entity3 . Contrast enhanced CT and MRI were used as the "Standard Of Reference" (SOR). Sensitivity, specificity and accuracy of liver @entity1 detection with US versus @entity3 , for each dose group were obtained. Dose group analysis was performed using the Chi-square test. RESULTS: 165 @entity1 were present in 92 @entity0 who each had 1-7 lesions present on the SOR. Sensitivity of US versus @entity3 (for all doses combined) was 38% and 67% (p   =   0.0001). The 0.12 dose group with @entity3 (78%) had significantly higher sensitivity and accuracy (70%) compared to other dose groups (p   <   0.05). CONCLUSION: The diagnostic performance of @entity3 is dose dependent with the 0.12  L/kg @entity5 dose group showing the greatest sensitivity and accuracy in detection of liver @entity1 .

title: Contrast enhanced ultrasound in the detection of liver @entity1 : a prospective multi-centre dose testing study using a XXXX microbubble contrast agent ( @entity5 ).

answer: @entity4


abstract: OBJECTIVE: To conduct a dose testing analysis of @entity4 microbubble ( @entity5 ) @entity3 ( @entity3 ) to determine the optimal dose for detection of liver @entity1 in @entity0 with extra-hepatic primary @entity2 . METHODS: 157 @entity0 were investigated with conventional US and @entity3 . @entity3 was performed following intravenous administration of @entity4 microbubbles (using one dose of either 0.008, 0.08, 0.12 or 0.36  L/kg body weight). Three blinded off-site readers recorded the number and locations of metastatic lesions detected by US and @entity3 . Contrast enhanced CT and MRI were used as the "Standard Of Reference" (SOR). Sensitivity, specificity and accuracy of liver @entity1 detection with US versus @entity3 , for each dose group were obtained. Dose group analysis was performed using the Chi-square test. RESULTS: 165 @entity1 were present in 92 @entity0 who each had 1-7 lesions present on the SOR. Sensitivity of US versus @entity3 (for all doses combined) was 38% and 67% (p   =   0.0001). The 0.12 dose group with @entity3 (78%) had significantly higher sensitivity and accuracy (70%) compared to other dose groups (p   <   0.05). CONCLUSION: The diagnostic performance of @entity3 is dose dependent with the 0.12  L/kg @entity5 dose group showing the greatest sensitivity and accuracy in detection of liver @entity1 .

title: Contrast enhanced ultrasound in the detection of liver @entity1 : a prospective multi-centre dose testing study using a @entity4 microbubble contrast agent ( XXXX ).

answer: @entity5


abstract: The clinical significance of @entity2 -infiltrating immune cells has been reported in a variety of @entity1 @entity3 including @entity0 . However, molecular signature of @entity2 -infiltrating immune cells and their prognostic value in @entity0 @entity1 remain elusive. We hypothesized that a distinct network of immune function genes at the @entity2 site can predict a low risk versus high risk of distant relapse in @entity0 @entity1 regardless of the status of ER, PR, or @entity5 in their @entity2 . We conducted retrospective studies in a diverse cohort of @entity0 @entity1 with a 1-5  year @entity2 relapse versus those with up to 7  years relapse-free survival. The RNAs were extracted from the frozen @entity2 specimens at the time of diagnosis and subjected to microarray analysis and real-time RT-PCR. @entity4 -embedded tissues were also subjected to immunohistochemistry staining. We determined that a network of immune function genes involved in B cell development, interferon signaling associated with allograft rejection and autoimmune reaction, antigen presentation pathway, and cross talk between adaptive and innate immune responses were exclusively upregulated in @entity1 with relapse-free survival. Among the 299 genes, five genes which included B cell response genes were found to predict with >85% accuracy relapse-free survival. Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX recurrence score assay panel. These data suggest that neoadjuvant immunotherapy in @entity1 with high risk of relapse may reduce @entity2 recurrence by inducing the immune function genes.

title: A signature of immune function genes associated with recurrence-free survival in XXXX @entity1 .

answer: @entity0


abstract: The clinical significance of @entity2 -infiltrating immune cells has been reported in a variety of @entity1 @entity3 including @entity0 . However, molecular signature of @entity2 -infiltrating immune cells and their prognostic value in @entity0 @entity1 remain elusive. We hypothesized that a distinct network of immune function genes at the @entity2 site can predict a low risk versus high risk of distant relapse in @entity0 @entity1 regardless of the status of ER, PR, or @entity5 in their @entity2 . We conducted retrospective studies in a diverse cohort of @entity0 @entity1 with a 1-5  year @entity2 relapse versus those with up to 7  years relapse-free survival. The RNAs were extracted from the frozen @entity2 specimens at the time of diagnosis and subjected to microarray analysis and real-time RT-PCR. @entity4 -embedded tissues were also subjected to immunohistochemistry staining. We determined that a network of immune function genes involved in B cell development, interferon signaling associated with allograft rejection and autoimmune reaction, antigen presentation pathway, and cross talk between adaptive and innate immune responses were exclusively upregulated in @entity1 with relapse-free survival. Among the 299 genes, five genes which included B cell response genes were found to predict with >85% accuracy relapse-free survival. Real-time RT-PCR confirmed the 5-gene prognostic signature that was distinct from an FDA-cleared 70-gene signature of MammaPrint panel and from the Oncotype DX recurrence score assay panel. These data suggest that neoadjuvant immunotherapy in @entity1 with high risk of relapse may reduce @entity2 recurrence by inducing the immune function genes.

title: A signature of immune function genes associated with recurrence-free survival in @entity0 XXXX .

answer: @entity1


abstract: PURPOSE: We sought to determine the association between health-related quality of life (HRQOL) and graft function in renal transplant recipients. DESIGN AND METHODS: We enrolled 577 kidney transplant recipients aged 18-74 years (response rate 87%). Recipients with multiple or multi-organ transplantation, @entity5 kinase >200 U/L, @entity4 or cellular rejection (n = 64), and without @entity6 assessments in 3 months pre-enrollment (n = 127) were excluded. The questionnaire included @entity8 QOL 5 Dimensions (EQ-5D), Health Utility Index III (HUI-III), @entity1 Quality of Life-36 (KDQOL36) which include a generic section (RAND SF-12). Data on medical conditions, therapy regimens, and biochemistry results were extracted from clinical charts. We used general linear models adjusted for demographic, socioeconomic, and clinical characteristics to assess the association between HRQOL and severity of @entity3 ( @entity3 ). RESULTS: @entity0 with more advanced @entity3 were more likely to be African-American, covered by public insurance, more likely to have shorter time after transplantation, higher @entity7 and lower hemoglobin, serum albumin, and @entity2 levels. All HRQOL scales were inversely associated with @entity3 severity. All associations were robust to adjustment for possible confounders. CONCLUSIONS: Several health-related quality of life dimensions may be affected by poor renal function after transplantation.

title: XXXX is associated with worse self-reported outcomes after kidney transplantation.

answer: @entity1


abstract: BACKGROUND: Robotic-assisted excision of a pelvic @entity3 is presented. METHODS: A 27 year-old female presented with occasional numbness of the right thigh. Imaging studies revealed a large mass adjacent to the right ovary. Robotic surgery with adjunctive electrophysiological monitoring was performed. The mass was adhered to the L4, L5 roots and was displacing the iliac vessels and the ureter. The @entity1 bulk was decompressed and total excision was facilitated. RESULTS: Pathology revealed a @entity1 consisting of spindle cells. Immunochemistry revealed S-100(+) and a growth index Ki-67 < 1%. These findings were consistent with the diagnosis of @entity3 . The intraoperative time was comparable to laparoscopy and the @entity0 had an uneventful recovery. CONCLUSION: @entity3 is often diagnosed only when it is large enough to produce symptoms. Robotic surgery with adjunctive electrophysiological monitoring is a safe technique for the @entity2 .

title: Robotic-assisted surgical XXXX : a novel approach to a rare variant.

answer: @entity2


abstract: UNASSIGNED: Oral anticoagulation is highly effective for @entity1 prevention in high-risk- @entity0 with @entity6 . AF is also a risk for @entity2 , and effective OAC reduces the risk of @entity2 . Up to 30% of @entity0 with @entity6 have a @entity3 and antiplatelets are used to avoid @entity5 complications]. @entity0 with @entity6 oft have an @entity7 und undergo a percutaneous intervention with stent-implantation. These @entity0 require a triple therapy, i.e. the combination of oral anticoagulation with dual-anti-platelet therapy. It is obvious that OAC may induce @entity4 with potentially deleterious effects on mortality. Even the occurrence of minor @entity4 is problematic. The review describes available data on used antithromboembolic regimens in @entity0 treated with oral anticoagulation ( @entity8 antagonists and non- @entity8 antagonists) who need a triple therapy (i.e. anticoagulation and antiplatelets). Most data are from @entity0 who were treated for an @entity7 and cannot be directly extrapolated for @entity0 with @entity6 . The impact of used stents and novel @entity9 antagonist-antiplatelets and duration of triple therapy is discussed. Often some high-risk @entity0 with @entity6 would need anticoagulation but cannot be given this therapy because of excessive @entity4 risks or contraindicating comorbidities: in these @entity0 left atrial appendage closure with an occluding device can be used as an alternative to antithromboembolic therapy- The unavoidable antithromboembolic triple therapy carries a strong potential for @entity4 events, which increase mortality. We have many data and several recommendations are offered. . Nonetheless, we lack solid data on the best antithromboembolic regimen in @entity0 with @entity6 who need anticoagulation and antiplatelets.

title: Antithromboembolic strategies in XXXX : A review.

answer: @entity6


abstract: BACKGROUND/AIMS: The aim of this study was to evaluate the efficacy, effects on survival and complications of self-expandable metal stent applications in @entity0 with @entity1 . METHODS: Twenty-five @entity0 undergoing metal stent insertion due to @entity1 between February 2005 and July 2009 were included in the present study. In all @entity0 , self-expandable metal stent 22 mm in diameter was inserted under scopic guidance. The @entity0 were evaluated regarding age, gender, etiology, efficacy of stent insertion, complications, and duration of patency of the stent. RESULTS: Of the 25 @entity0 included in the study, 15 were female and 10 were male. Their mean age was 65.9 years (57-81 years). The most common etiological causes were @entity1 (n=10, 40%) and @entity2 (n=8, 32%). Duodenal stent was inserted successfully in all @entity0 . In 4 @entity0 , percutaneous biliary metal stent was inserted at the same time due to @entity4 . No mortality occurred during the procedure. A second stent was inserted in 4 @entity0 due to stent migration. The @entity0 were followed for a mean of 92 days (7 to 258 days) after the procedure. The stents remained clinically patent in all @entity0 during the follow-up period until death. CONCLUSIONS: Insertion of duodenal metal stent is an effective and safe therapeutic approach in the palliative treatment of malignant @entity3 .

title: Palliative treatment of XXXX : Applications of self-expandable metal stent.

answer: @entity1


abstract: BACKGROUND: Aim of the study was to assess results of treatment and quality of life of @entity0 with hemifacial @entity6 (HFS) after microvascular decompression and to analyze intraoperative data in surgical revision of intracranial portion of @entity5 . MATERIALS AND METHODS: The study included 30 @entity0 with HFS who underwent microvascular decompression. Duration of symptoms varied between 1 and 30 years (mean--6.7 years). Typical manifestation of @entity6 was observed in 28 cases, atypical--in 22. Severity of @entity7 and its influence on everyday activity were assessed using 5-grade scale (by E. Tan), and surgical results--according to degree of clinical improvement combined with evaluation of quality of life using scale HFS-7. RESULTS. Most frequent type of conflict observed in the series was contact between @entity5 and AICA (64.4%). Compression of @entity5 root entry zone was revealed in vast majority of cases (93.3%), and in 2 @entity0 (6.7%) site of compression was distal to the root entry zone. In a female @entity0 with secondary HFS due to the @entity1 relations of @entity4 were altered and their displacement produced conflict between AICA loop and @entity5 . In our series @entity3 of different severity was observed in 16.7% of @entity0 . This disorder is persistent and does not regress in the follow-up period. All other symptoms of @entity2 are amenable to resolve within 1-2 months. CONCLUSION: Microvascular decompression of @entity5 is pathogenetically feasible and effective method of treatment of HFS. It allows achievement of consistent regression of symptoms and improvement of quality of life of @entity0 with HFS.

title: [Long-term results of microvascular decompression in treatment of hemifacial XXXX ].

answer: @entity6


abstract: BACKGROUND: SYNTAX score II (SS-II) has been demonstrated to predict long-term outcomes in unprotected left main or multiple vessels in @entity0 with @entity1 . But its prognostic value for @entity0 with @entity2 ( @entity2 ) remains unknown. The poor myocardial perfusion (myocardial blush grade, @entity3 0/1) after primary percutaneous coronary intervention (PPCI) has a negative prognostic value in @entity0 with @entity2 . We aimed to assess SS-II and its possible relationships with @entity3 0/1 in @entity0 with @entity2 treated with PPCI. METHODS: The study included 477 @entity0 with @entity2 who underwent PPCI between October 2010 and May 2014. The SS-II and @entity3 were determined in all @entity0 . @entity3 were divided into @entity3 0/1 (poor myocardial perfusion) and @entity3 2/3 (normal myocardial perfusion). @entity0 were divided into 3 tertiles: SS-II low ( <= 20), SS-II intermediate (20-26) and SS-II high (>=  26). RESULTS: Compared with the SS-II intermediate and SS-II low tertiles, the SS-II high tertile had more @entity3 0/1 (46.1%, 32.1% and 21.8%, p<0.001, respectively). On multivariate logistic regression analysis, SS-II was an independent predictor of @entity3 0/1 (Hazard ratio [HR]: 1.084, 95% CI: 1.050 to 1.119; p<0.001). Receiver operating characteristic (ROC) analysis identified SS-II > 24 as the best cut-off value predicting @entity3 0/1 (sensitivity of 66%, specificity of 54%). CONCLUSIONS: High SS-II is an independent predictor of @entity3 0/1 in @entity0 with @entity2 undergoing PPCI.

title: Does SYNTAX score II predict poor myocardial perfusion in XXXX ?

answer: @entity2


abstract: @entity1 ( @entity1 ) for care-dependent older @entity0 gain increasing importance as a setting for nursing care in Germany, both in terms of numbers and user preference. This article aims to answer the questions in which phases @entity1 have developed over time, what the initiator's objectives are, and what factors contributed to @entity1 proliferation. A systematic review of the literature was conducted that finally included 73 articles. As a result it can be demonstrated that @entity1 started from "individual user initiatives", became "developing novel services" and finally established themselves as "regular services" in the nursing setting. A typology of different models of @entity1 can be organised along two dimensions: Firstly the temporal dimension of care organisation and secondly the way care services are purchased. Objectives formulated by the initiators of @entity1 are: Establishment of a family - like environment, inclusion of relatives, community orientation, security of care provision and maintenance of self-determination. Tailor-made financial and legal regulations supported the spread of SHAs. In reflection of the available literature it becomes evident that no satisfactory consensus on those elements exist that are constitutive for SHAs. Furthermore, there is a dearth of research on whether postulated objectives and other health related goals are actually being met in SHAs. Open questions pertain also the level of self-determination achieved in practice and other outcomes attained.

title: [Shared-housing arrangements for care-dependent older XXXX - characteristics, development and drivers].

answer: @entity0


abstract: BACKGROUND/AIMS: This study aimed to demonstrate the efficacy and tolerability of low-dose weekly @entity2 as a radiosensitizer in unresectable @entity6 @entity0 treated with chemoradiotherapy. METHODS: Twenty-four histologically confirmed @entity8 @entity0 (female/male: 10/14, median age: 60) were evaluated. Seven (29%) @entity0 received @entity2 either as a single agent or in combination prior to chemoradiotherapy. Concurrent 75 mg/m2 @entity2 was infused weekly. Radiotherapy was delivered to the @entity1 and positive lymphatics with 3D-conformal radiotherapy to a total dose of 4500 cGy. Local progression-free survival, distant metastasis-free survival and overall survival were evaluated by Kaplan-Meier method. RESULTS: Median follow-up was 36 weeks. Median local progression-free survival, distant metastasis-free survival and overall survival were 22 weeks (95% confidence interval [CI]: 5-59 weeks), 19 weeks (95%CI: 6.9-31 weeks) and 36 weeks (95%CI: 28-43 weeks), respectively. All @entity0 completed radiotherapy as scheduled. Concurrent @entity2 was given fully in 58.3% of @entity0 . @entity2 was terminated in four (16.6%) @entity0 due to grade 3 @entity7 (n=1), grade 3 @entity4 / @entity5 (n=2) or @entity0 's reluctance (n=1). @entity0 with local response and stable disease to chemoradiotherapy revealed a median survival of 39 weeks (95%CI: 30-47.9 weeks) compared to 36 weeks (95%CI: 9.7-62.2 weeks) in @entity0 with locally progressive disease (p=0.52). @entity3 was improved in 50% of @entity0 . CONCLUSIONS: Weekly low-dose radiosensitizing @entity2 is effective and safe in unresectable @entity6 @entity0 .

title: Concomitant chemoradiotherapy with low-dose weekly @entity2 for nonmetastatic unresectable XXXX .

answer: @entity6


abstract: BACKGROUND/AIMS: This study aimed to demonstrate the efficacy and tolerability of low-dose weekly @entity2 as a radiosensitizer in unresectable @entity6 @entity0 treated with chemoradiotherapy. METHODS: Twenty-four histologically confirmed @entity8 @entity0 (female/male: 10/14, median age: 60) were evaluated. Seven (29%) @entity0 received @entity2 either as a single agent or in combination prior to chemoradiotherapy. Concurrent 75 mg/m2 @entity2 was infused weekly. Radiotherapy was delivered to the @entity1 and positive lymphatics with 3D-conformal radiotherapy to a total dose of 4500 cGy. Local progression-free survival, distant metastasis-free survival and overall survival were evaluated by Kaplan-Meier method. RESULTS: Median follow-up was 36 weeks. Median local progression-free survival, distant metastasis-free survival and overall survival were 22 weeks (95% confidence interval [CI]: 5-59 weeks), 19 weeks (95%CI: 6.9-31 weeks) and 36 weeks (95%CI: 28-43 weeks), respectively. All @entity0 completed radiotherapy as scheduled. Concurrent @entity2 was given fully in 58.3% of @entity0 . @entity2 was terminated in four (16.6%) @entity0 due to grade 3 @entity7 (n=1), grade 3 @entity4 / @entity5 (n=2) or @entity0 's reluctance (n=1). @entity0 with local response and stable disease to chemoradiotherapy revealed a median survival of 39 weeks (95%CI: 30-47.9 weeks) compared to 36 weeks (95%CI: 9.7-62.2 weeks) in @entity0 with locally progressive disease (p=0.52). @entity3 was improved in 50% of @entity0 . CONCLUSIONS: Weekly low-dose radiosensitizing @entity2 is effective and safe in unresectable @entity6 @entity0 .

title: Concomitant chemoradiotherapy with low-dose weekly XXXX for nonmetastatic unresectable @entity6 .

answer: @entity2


abstract: BACKGROUND: Iatrogenic colon perforation is a rare but life-threatening complication of colonscopy. As in other diseases, laparoscopic treatment has increasingly been propagated for the treatment of @entity3 in the last years. The aim of this comparative study was to answer the question of whether laparoscopic surgical treatment may serve as a suitable treatment for the acute colon perforation comparable to open surgery. @entity0 AND METHODS: The data of all @entity0 who underwent surgery for @entity2 within a 13-year time period (1997-2009) were recorded prospectively and analysed retrospectively with regard to different perioperative parameters. In the following analysis the laparoscopically and open surgically treated @entity0 were compared. RESULTS: In the observation period 24 @entity0 with @entity2 were treated laparoscopically and 12 @entity0 with open surgery. There were no significant differences concerning age in both groups. In both groups resection of the affected region was preferred [open surgically: 58 % (n = 7), laparoscopically: 80 % (n = 19)]. The median operation time was 105 min (range: 35 - 180) for the open surgically treated @entity0 and 165 min (90 - 420) for laparoscopic procedures (p = 0.006). In 4 cases of the laparoscopic group a conversion via laparotomy was -necessary. There was no significant difference concerning the hospital stay between both groups with 14.5 days (7-40) for the open surgical and 11 days (7-25) for the laparoscopic group. Concerning the postoperative morbidity a significantly higher incidence could be seen in the open surgical group (p < 0.0001). CONCLUSION: An @entity2 mostly leeds to the immediate indication for a surgical treatment. The morbidity and mortality is -primarily determined through the appearance of @entity1 due to delays in diagnostics and treatment. In this study the feasibility of a laparoscopic treatment could be shown. The laparoscopy with its minimal access trauma offers an enlargement of the diagnostics as well as a safe treatment of the perforation in most @entity0 . However, the laparoscopic treatment especially in emergancy situations requires -advanced experience of the surgeon and always needs a critical benefit-risk consideration in the individual situation.

title: [Open surgical versus laparoscopic treatment of XXXX - results of a 13-year experience].

answer: @entity2


abstract: 215 @entity0 with @entity2 ( @entity2 ) were treated at the Royal Marsden Hospital between 1963 and 1985 (median follow-up 9 years). The actuarial 5- and 10-year survival was 77 and 65%, respectively with 55 and 48% 5 and 10 year disease-free survival. Of 13 variables tested, age was the only independent prognostic indicator for survival on multivariate analysis. @entity0 aged under 40, 40-59 and over 60 years had a 10-year survival of 76, 41 and 8%, respectively (p much less than 0.001). Ninety-one @entity0 were initially treated with combined chemotherapy and radiotherapy (combined modality therapy, @entity3 ), 73 @entity0 with radiotherapy (RT) and 51 @entity0 with chemotherapy (CT) alone. @entity0 under 40 years treated with @entity3 achieved the best disease-free survival (10 year disease-free survival: @entity3 68%; RT 38%; CT 45%). The observed survival advantage for @entity3 was not statistically significant. In @entity0 aged greater than 40 there was no survival or disease-free survival advantage following @entity3 . Analysis of recurrence pattern confirmed that @entity3 improves @entity1 control both at previously involved and uninvolved sites. Recurrences at previously uninvolved sites continued up to 6 years following CT, up to 8 years following @entity3 and up to 14 years after RT alone. These results indicate that only long-term follow-up gives the true picture of stage III @entity2 .

title: XXXX --long-term results following chemotherapy, radiotherapy and combined modality therapy.

answer: @entity2


abstract: The @entity5 @entity3 ( @entity3 ), representing the percentage of cells in the DNA-synthesis phase, was measured in vitro prior to therapy in 87 @entity0 with @entity4 of the @entity2 , who were treated between 1977 and 1982. The @entity3 was not related to @entity0 age, site of the @entity1 , clinical stage or histological grade. Overall survival was 44.5%. Univariate analysis demonstrated that survival was affected by the following factors: (1) age: @entity0 older than 55 had a better outcome (p = 0.03); (2) site of the @entity1 (p = 0.005): @entity1 had the best survival; (3) clinical stage (p = 0.05). Histological grade did not influence the survival (p = 0.41). @entity0 having a @entity1 higher than 15.5% (mean + 1 S.D.) had a significantly lower survival than @entity0 with lower @entity1 (p = 0.008). A multivariate analysis using the Cox model showed that clinical stage and @entity3 kept their prognostic impact with regard to survival. Finally, survival after relapse was lower in @entity0 with a high @entity1 . These results demonstrate that a high @entity1 proliferation rate is an additional factor influencing the disease outcome in @entity2 . @entity0 with bad prognosis defined by this parameter could be offered a more energetic treatment.

title: The XXXX : a prognostic factor in @entity2 .

answer: @entity3


abstract: The @entity5 @entity3 ( @entity3 ), representing the percentage of cells in the DNA-synthesis phase, was measured in vitro prior to therapy in 87 @entity0 with @entity4 of the @entity2 , who were treated between 1977 and 1982. The @entity3 was not related to @entity0 age, site of the @entity1 , clinical stage or histological grade. Overall survival was 44.5%. Univariate analysis demonstrated that survival was affected by the following factors: (1) age: @entity0 older than 55 had a better outcome (p = 0.03); (2) site of the @entity1 (p = 0.005): @entity1 had the best survival; (3) clinical stage (p = 0.05). Histological grade did not influence the survival (p = 0.41). @entity0 having a @entity1 higher than 15.5% (mean + 1 S.D.) had a significantly lower survival than @entity0 with lower @entity1 (p = 0.008). A multivariate analysis using the Cox model showed that clinical stage and @entity3 kept their prognostic impact with regard to survival. Finally, survival after relapse was lower in @entity0 with a high @entity1 . These results demonstrate that a high @entity1 proliferation rate is an additional factor influencing the disease outcome in @entity2 . @entity0 with bad prognosis defined by this parameter could be offered a more energetic treatment.

title: The @entity3 : a prognostic factor in XXXX .

answer: @entity2


abstract: Cardiomyocyte dedifferentiation, as detected in hibernating @entity7 of chronic @entity1 @entity0 , is one of the characteristics seen at the border of @entity3 in small and large animals. Our objectives were to study in detail the morphological changes occurring at the border zone of a @entity2 @entity3 and its use as model for hibernating @entity7 . Ligation of the left coronary artery (LAD) was performed on @entity2 hearts and animals were sacrificed at 2, 4, 8 and 12 weeks post- @entity6 . These hearts together with a non-infarcted control heart were perfusion-fixed and tissue samples were embedded in @entity4 resin. Hibernating cardiomyocytes were mainly distributed in the non-infarcted region adjacent to the border zone of infarcted @entity7 but only in a limited number. In the border zone itself vacuolated cardiomyocytes surrounded by fibrotic tissue were frequently observed. Ultrastructural analysis of these vacuolated cells revealed the presence of a basal lamina inside the vacuoles adjacent to the surrounding membrane, the presence of pinocytotic vesicles and an association with cisternae of the sarcoplasmatic reticulum. Myocyte quantitative analyses revealed a gradual increase in vacuolar area/total cell area ratio and in collagen fibril deposition inside the vacuoles from 2 to 12 weeks post- @entity6 . Related to the remote zone, the increase in cell width of myocytes located in and adjacent to the border zone demonstrated cellular @entity5 . These results indicate the occurrence of cardiomyocyte remodelling mechanisms in the border zone and adjacent regions of infarcted @entity7 . It is suggested that the vacuoles represent plasma membrane invaginations and/or dilatations of T-tubular structures.

title: Structural remodelling of cardiomyocytes in the border zone of infarcted XXXX heart.

answer: @entity2


abstract: This study investigated whether a novel ionogenic substance, containing amongst others @entity0 and @entity4 (PHI-5; Dermagenics Inc, Memphis, TN, USA), could improve the healing of full-thickness @entity1 . Uniform wounds were created on the right flank of @entity2 . Micro-grooved @entity3 rubber membranes, containing 0 (controls), 1.25, 5.00, or 10.00 microg PHI-5, were sutured onto this wound. Standardized digital wound photographs were made after 1, 3, and 6 weeks. Also, wound biopsies were taken after 3 and 6 weeks for histological and histomorphometrical evaluation. For all study groups, 6 animals were used. Analysis of the 1-week digital photographs showed that the surface area of the wounds decreased significantly, with an increasing PHI-5 concentration. No other differences were found in the wound photographs. Also, no differences were measured in histomorphometry at 3 and 6 weeks. Concluding, in our study model a single application of PHI-5 did have a significant positive influence on initial wound healing.

title: The influence of a PHI-5-loaded XXXX membrane, on cutaneous wound healing in vivo.

answer: @entity3


abstract: Articular involvement was reported to be present in approximately 5-76% of Beh  et @entity0 . Therefore, we need a useful non-invasive method to detect articular involvement early in Beh  et @entity0 with nonspecific complaints. We aimed to evaluate the usefulness of @entity4 ( @entity4 ) bone scintigraphy in the detection of the articular involvement of @entity1 ( @entity1 ). Bone scintigraphy with @entity4 was performed in 32 (17 male, 15 female) consecutive @entity0 with @entity1 . The sacroiliac (SI) joints with SI index higher than 1.34 were diagnosed as having @entity3 . Although joint complaints were present in only 8 (25%) @entity0 , we detected joint involvement by scintigraphy in 27/32 (84.4%) Beh  et @entity0 mostly affecting the knees (62.5%), ankles (59.4%), @entity2 (25%), wrists (21.9%), shoulders (18.7%), elbows (12.5%) and hips (3.1%). The articular involvement was monoarticular in four cases (12.5%) and was oligoarticular in the remaining. There was no correlation between joint involvement and age, gender, disease duration, drug usage or other clinical manifestations. Despite the fact that our @entity0 were clinically asymptomatic and had normal pelvis radiography, @entity3 was found in 8 @entity0 (25%). Bone scintigraphy is sensitive in the diagnosis of joint involvement allowing earlier diagnosis and showing the presence of articular involvement, especially in @entity2 .

title: The usefulness of XXXX bone scintigraphy in detection of articular involvement of @entity1 .

answer: @entity4


abstract: Articular involvement was reported to be present in approximately 5-76% of Beh  et @entity0 . Therefore, we need a useful non-invasive method to detect articular involvement early in Beh  et @entity0 with nonspecific complaints. We aimed to evaluate the usefulness of @entity4 ( @entity4 ) bone scintigraphy in the detection of the articular involvement of @entity1 ( @entity1 ). Bone scintigraphy with @entity4 was performed in 32 (17 male, 15 female) consecutive @entity0 with @entity1 . The sacroiliac (SI) joints with SI index higher than 1.34 were diagnosed as having @entity3 . Although joint complaints were present in only 8 (25%) @entity0 , we detected joint involvement by scintigraphy in 27/32 (84.4%) Beh  et @entity0 mostly affecting the knees (62.5%), ankles (59.4%), @entity2 (25%), wrists (21.9%), shoulders (18.7%), elbows (12.5%) and hips (3.1%). The articular involvement was monoarticular in four cases (12.5%) and was oligoarticular in the remaining. There was no correlation between joint involvement and age, gender, disease duration, drug usage or other clinical manifestations. Despite the fact that our @entity0 were clinically asymptomatic and had normal pelvis radiography, @entity3 was found in 8 @entity0 (25%). Bone scintigraphy is sensitive in the diagnosis of joint involvement allowing earlier diagnosis and showing the presence of articular involvement, especially in @entity2 .

title: The usefulness of @entity4 bone scintigraphy in detection of articular involvement of XXXX .

answer: @entity1


abstract: This study aims to compare radiographic healing rates of Austin bunionectomies in smokers, nonsmokers, and secondhand smokers. Delayed @entity1 has been linked to cigarette smoking previously, but no study is known to have examined smoking in relation to elective foot surgery. We hypothesized that smoking will delay @entity1 after elective foot surgery. Surgical @entity0 were placed into 1 of 3 cigarette smoking-related groups. @entity3 @entity2 was measured by the standardized modified Fagerstr  m est and a urine @entity4 test. Bone healing was determined via examination of postsurgical radiographs. Outcomes were assessed with 1-way analyses of variance. Forty-six @entity0 were prospectively evaluated. There were 17 smokers, 12 secondhand smokers, and 17 nonsmokers. Healing time after Austin bunionectomy was 69 days (SD = 26.0), 120 days (SD = 55.3), and 78 days (SD = 19.1) in nonsmokers, smokers, and secondhand smokers, respectively. It was noted that as urine @entity4 number increased, the healing time also increased (Pearson correlation = -.314, P < .01). The same was noted with the score associated with the Fagerstr  m questionnaire, showing an increase in healing time with an increase in score (Pearson correlation = -.128, P < .05). The osteotomy of a smoker took 1.73 times longer to reach radiographic bone consolidation than that of a nonsmoker. This equates to a 42% increase in time to @entity1 in the smoking @entity0 . Increased healing time was also correlated to increased urine @entity4 and a higher Fagerstr  m number. Smoking is shown to delay radiographic healing. LEVEL OF CLINICAL EVIDENCE: 2.

title: The effect of cigarette smoking on radiographic XXXX after elective foot surgery.

answer: @entity1


abstract: PURPOSE: This work was undertaken to determine the clinical course and prognostic factors in @entity0 with primary @entity7 ( @entity7 ). MATERIAL AND METHODS: 64 @entity0 were enrolled, including 26 females and 38 males, aged 22 to 80 years. The diagnosis of @entity7 was made on the basis of histopathologic examination of samples collected during gastroscopy in 50 or gastrectomy in 14 @entity0 . A retrospective analysis was performed of the relationship between the outcome of treatment and age, gender, histological type of the @entity6 , clinical staging according to the original Ann Arbor classification and as modified by Stein and coworkers, functional status according to the ECOG scale, International Prognostic Index, type of @entity6 according to the classification of Kramer, and type of primary therapy. Survival probability was calculated according to Kaplan-Meier. RESULTS: The results are presented in figures and tables. CONCLUSIONS: 1. The clinical picture of primary @entity7 is unrevealing. @entity0 usually complain of @entity1 , @entity4 , @entity5 , and @entity3 . Clinical symptoms are rarely typical of a @entity2 . 2. Age, gender, functional status, histological type of the @entity6 , and clinical stage do not correlate with treatment outcome and survival. 3. Gastrectomy as the primary method of treatment has no advantage over chemotherapy in terms of treatment outcome and survival.

title: [Primary XXXX : clinical findings and prognostic factors].

answer: @entity7


abstract: AIM: The aim of this study was to assess the ability of artificial neural network (ANN) in predicting survival in @entity0 undergoing surgical resection for @entity2 and oesophago-gastric junction. METHODS: From January 1995 to August 2004 @entity0 who underwent surgery for oesophageal and @entity3 were identified. Biographical data, body mass index and pathological minimal @entity1 dataset were used to design an ANN. Post-operative survival was assessed at 1 and 3 years. Sixty percent of data was used to train and validate the ANN and 40% was used to evaluate the accuracy of trained ANN in predicting survival. This was compared with Union Internacional Contra la Cancrum UICC TNM classification system. RESULTS: Two hundred and sixteen @entity0 underwent resectional surgery for oesophageal and OGJ @entity2 . The accuracy of the ANN in predicting survival at 1 and 3 years was 88% (sensitivity: 92.3%, specificity: 84.5%, DP = 2.3) and 91.5% (sensitivity of 94.61%, specificity: 88%, DP = 2.72), respectively. These figures were significantly better than 1- and 3-year survival predictions using the UICC TNM classification system 71.6% (sensitivity of 66.4%, specificity: 75.5%, and @entity4 ) and 74.7% (sensitivity of 70.5%, specificity: 74.9%, @entity4 ), respectively (P < 0.01) (P < 0.05). CONCLUSION: ANNs are superior to the UICC TNM classification system in correlating with survival following resection of @entity2 and OG junction and can become valuable tools in the management of @entity0 with @entity2 .

title: Prediction of survival from XXXX and oesophago-gastric junction following surgical resection using an artificial neural network.

answer: @entity2