abstract: UNASSIGNED: A novel method of harvesting whole-plant @entity1 silage, shredlage, may increase kernel processing and physically effective fiber. Improved fiber effectiveness may be especially advantageous when feeding brown midrib (BMR) @entity1 hybrids, which have reduced lignin content. The objective of this study was to determine the effect of feeding TMR containing BMR @entity1 shredlage (SHRD) compared with BMR conventionally processed @entity1 silage (KP) or KP plus chopped alfalfa hay (KPH) on intake, lactation performance, and total-tract nutrient digestibility in dairy @entity0 . The KP was harvested using conventional rolls (2-mm gap) and the self-propelled forage harvester set at 19 mm of theoretical length of cut, whereas SHRD was harvested using novel cross-grooved rolls (2-mm gap) and the self-propelled forage harvester set at 26 mm of theoretical length of cut. Holstein @entity0 (n = 120; 81    8 d in @entity2 at trial initiation), stratified by parity, days in @entity2 , and @entity2 yield, were randomly assigned to 15 pens of 8 @entity0 each. Pens were randomly assigned to 1 of 3 treatment diets, SHRD, KP, or KPH, in a completely randomized design using a 2-wk covariate period with @entity0 fed a common diet followed by a 14-wk treatment period with @entity0 fed their assigned treatment diet. The TMR contained (dry matter basis) KP or SHRD forages (45%), alfalfa silage (10%), and a concentrate mixture (45%). Hay replaced 10% of KP silage in the KPH treatment TMR (dry matter basis). @entity2 , protein, and lactose yields were 3.4, 0.08, and 0.16 kg/d greater, respectively, for @entity0 fed KP and SHRD than KPH. A week by treatment interaction was detected for @entity2 yield, such that @entity0 fed SHRD produced or tended to produce 1.5 kg/d per @entity0 more @entity2 , on average, than @entity0 fed KP during 6 of the 14 treatment weeks. Component-corrected @entity2 yields were similar among treatments. @entity0 fed KPH had greater @entity2 fat concentration than @entity0 fed KP and SHRD (3.67 vs. 3.30% on average). Consumption of dry matter, rumination activity, and sorting behavior were similar among treatments. Ruminal in situ starch digestibility was greater for SHRD than KP forages, and total-tract dietary starch digestibility was greater for SHRD than KP. @entity2 yield and starch digestibility were greater for SHRD than KP. Lack of improvement in @entity2 fat content and rumination activity for SHRD compared with KP and reduced @entity2 fat content for SHRD compared with KPH, however, suggest no improvement in physically effective fiber from the longer theoretical length of cut used with SHRD in a BMR hybrid.

title: Brown midrib XXXX shredlage in diets for high-producing dairy @entity0 .

answer: @entity1


abstract: UNASSIGNED: @entity0 babesiosis occurs mainly in tropical and subtropical areas. The @entity0 parasite @entity1 sp. Xinjiang is widespread in China, and our goal is to characterize rap-1 (rhoptry-associated protein 1) gene diversity and expression as a first step of a long term goal aiming at developing a recombinant subunit vaccine. Seven different @entity4 genes were amplified in @entity1 sp. Xinjiang, using degenerate primers designed from conserved motifs. @entity5 and rap-1c gene types could not be identified. In all seven @entity4 genes, the 5' regions exhibited identical sequences over 936nt, and the 3' regions differed at 28 positions over 147nt, defining two types of genes designated a and b. The remaining 3' part varied from 72 to 360nt in length, depending on the gene. This region consists of a succession of two to ten 36nt repeats, which explains the size differences. Even if the @entity3 sequences varied, 6 repeats encoded the same stretch of @entity2 . Transcription of at least four a and two b genes was demonstrated by standard RT-PCR.

title: Rhoptry-associated protein (rap-1) genes in the XXXX pathogen @entity1 sp. Xinjiang: Multiple transcribed copies differing by 3' end repeated sequences.

answer: @entity0


abstract: UNASSIGNED: @entity0 babesiosis occurs mainly in tropical and subtropical areas. The @entity0 parasite @entity1 sp. Xinjiang is widespread in China, and our goal is to characterize rap-1 (rhoptry-associated protein 1) gene diversity and expression as a first step of a long term goal aiming at developing a recombinant subunit vaccine. Seven different @entity4 genes were amplified in @entity1 sp. Xinjiang, using degenerate primers designed from conserved motifs. @entity5 and rap-1c gene types could not be identified. In all seven @entity4 genes, the 5' regions exhibited identical sequences over 936nt, and the 3' regions differed at 28 positions over 147nt, defining two types of genes designated a and b. The remaining 3' part varied from 72 to 360nt in length, depending on the gene. This region consists of a succession of two to ten 36nt repeats, which explains the size differences. Even if the @entity3 sequences varied, 6 repeats encoded the same stretch of @entity2 . Transcription of at least four a and two b genes was demonstrated by standard RT-PCR.

title: Rhoptry-associated protein (rap-1) genes in the @entity0 pathogen XXXX sp. Xinjiang: Multiple transcribed copies differing by 3' end repeated sequences.

answer: @entity1


abstract: OBJECTIVE: To present and evaluate an unselected national single center strategy with fertility preserving trachelectomy in @entity1 . In 2003 nationwide single-center referral of @entity0 for trachelectomies was agreed upon between all Danish departments performing @entity1 surgery with the purpose of increasing volume, to increase surgical safety and facilitate follow-up. METHODS: Prospective data were recorded in the Danish Gynecological Cancer Database of all Vaginal Radical Trachelectomies (VRT) performed in Denmark between 2002 and 2013. Oncologic, fertility and obstetrical outcomes of 120 unselected consecutive VRTs were assessed. To obtain complete follow-up about fertility treatment, pregnancy and obstetric outcome the @entity0 filled out an electronic questionnaire. Median follow-up: 55.7 months. RESULTS: 85.8% of the @entity0 had stage @entity2 disease, 68.3% squamous cell carcinomas, 30.0% adenocarcinomas and 1.7% adenosquamous carcinomas. Six recurrences (5.1%) and 2 deaths (1.7%) occurred. Four @entity0 with adenocarcinomas (10.5%) had recurrences, compared to two @entity0 with squamous cell carcinomas (2.5%). Seventy-two @entity0 (60.0%) desired to conceive and 55 @entity0 obtained a total of 77 pregnancies. Of the 72 @entity0 40 were referred to fertility treatment. First and second trimester miscarriage rates were 21.6% and 2.7%, respectively. A total of 53 @entity0 were born of which 41 were delivered after gestational week 34. CONCLUSION: This unselected national single center referral study confirms the oncological safety of Vaginal Radical Trachelectomy. The complete follow-up regarding reproductive data, reveals a surprisingly extensive need of fertility treatment and due to the rate of prematurity, these pregnancies must be regarded as high-risk pregnancies.

title: Vaginal Radical Trachelectomy for early XXXX . Results of the Danish National Single Center Strategy.

answer: @entity1


abstract: AIMS: To clone and characterize sanO, a gene involved in the biosynthesis of @entity1 in Streptomyces ansochromogenes. METHODS AND RESULTS: A 4.5-kb BamHI-KpnI fragment was cloned and sequenced. Sequence analysis revealed that this fragment contains three complete open reading frames. The largest one with 2034 bp was designated sanO, which encodes a protein consisting of 667 @entity0 with high similarity to module of peptide synthetase. sanO disruption mutants produced no @entity2 , but formed @entity3 at almost the same level of the wild-type strain. The production of @entity2 can be recovered by genetic complementation of sanO disruption mutants. Primer extension also revealed that transcription start point(tsp) of sanO was localized 87 bp upstream of the potential start codon (GTG). CONCLUSIONS: sanO was essential for the biosynthesis of @entity2 . SIGNIFICANCE AND IMPACT OF THE STUDY: Nikkomycins have received increased interest of study because of their prospective application in agriculture and medicine. Cloning and characterization of genes involved in the @entity3 biosynthesis will help to elucidate the whole biosynthetic pathway of nikkomycins.

title: Cloning and characterization of sanO, a gene involved in XXXX biosynthesis in Streptomyces ansochromogenes.

answer: @entity3


abstract: BACKGROUND: The objective of this study was to construct and validate a brief, clinically-relevant symptom index for @entity3 . METHODS: Questions were extracted from a commonly-used multi-dimensional @entity1 quality of life instrument with prostate-specific items, the Functional Assessment of Cancer Therapy-Prostate (FACT-P). Surveys of disease-related symptoms were presented to an international sample of 44 expert physicians. Each expert narrowed the list to no more than five of the most important symptoms or concerns to monitor when assessing the value of treatment for @entity3 . Symptoms/concerns endorsed at a frequency greater than chance probability (17%) were retained for the symptom index and called the FACT Advanced Prostate Symptom Index-8 (FAPSI-8): @entity2 (three items), @entity5 , @entity4 , urinary difficulties (two items), and concern about the condition becoming worse. The FAPSI-8 was validated using data from a clinical trial of 288 @entity0 being treated for hormone @entity3 . RESULTS: The FAPSI-8 showed good internal consistency (r = 0.67-0.80); association with existing FACT scales (e.g., FACT-P, Physical Well-being, Functional Well-being; r = 0.44-0.85, p <.0001), responsiveness to clinical change (Guyatt's Responsiveness statistic = 1.29), and ability to differentiate @entity0 by performance status (p <.0001). A six-item alternate version of the FAPSI was also evaluated with comparable results. CONCLUSIONS: This project produced a reliable and valid list of the eight most important clinician-rated targets of drug therapy for @entity3 . These questions perform comparably to the longer derivative questionnaire. Examination of @entity0 agreement with this priority list and the extent to which changes in these 8 targets are related to meaningful clinical benefit to the @entity0 are important next steps for future research.

title: Brief assessment of priority symptoms in hormone XXXX : the FACT Advanced Prostate Symptom Index (FAPSI).

answer: @entity3


abstract: The objective of the study was to measure the utilization and diagnostic value of tests used in the @entity1 ( @entity1 ) on @entity0 with undifferentiated @entity2 . Specific goals were to measure how often these tests led to changes in diagnosis or disposition, which tests were most commonly used, and which tests providers considered most helpful. We conducted a pilot single-center, prospective descriptive study, enrolling all eligible adult @entity0 who presented to our @entity1 with @entity2 during defined hours of our intake period. Based on serial provider interviews pre- and post-testing, we measured the frequency of change of most likely diagnosis and disposition, which tests were performed, and the provider-perceived value of tests. We enrolled 124 subjects with a mean age of 44 years; 27% were admitted. Testing led to a change in most likely diagnosis in 37% of subjects, and in disposition in 41%. Frequency of diagnostic test use varied from a high of 93% for CBC to 6% for a blood or urine culture. Overall, 65% of @entity0 had at least one imaging study performed, and 39% had an abdominal/pelvic computed tomography (CT) scan. Over all subjects, providers identified the most useful tests as the CT scan (31%) and urinalysis (17%). In conclusion, among @entity1 @entity0 who presented with @entity2 to one @entity3 center, the pre-test most likely diagnosis and disposition were changed based on the @entity1 evaluation in over one-third of subjects. Almost all received blood tests and two-thirds received one or more imaging studies. Based on providers' subjective opinions, the most valuable tests were the abdomino/pelvic CT scan and the urinalysis.

title: Use of diagnostic testing in the emergency department for XXXX presenting with non-traumatic abdominal pain.

answer: @entity0


abstract: The study was carried out to analyze peripheral blood covering 23 @entity0 with prevalent phases of @entity6 received no treatment previously. The clinical analysis of blood was implemented using hematologic analyzer Sysmex XE-2100. The content of ferritin, soluble receptors of @entity2 and @entity7 was estimated using enzyme-linked immunosorbent assay. The free hemoglobin was estimated using hemoglobin cyanide method. The direct Coombs test, counting of leukogram and analysis of morphology of erythrocytes were applied to all @entity0 . The @entity4 is diagnosed in 19 @entity0 (83%). In 18 out of them the @entity5 corresponded to @entity4 and in one @entity0 asiderotic @entity4 was established. The rest of @entity0 had no @entity4 . The @entity4 of @entity3 characterized by microcytosis and hypochromia of erythrocytes, inadequate degree of @entity4 by production of @entity7 and functional deficiency of @entity1 in most of the @entity0 . It should be emphasized that @entity4 of @entity3 commonly is normocyte normochrome @entity4 whereas in @entity0 with prevalent phases of Hodgkin Iymphoma the microcyte hypochrome @entity4 was detected before the treatment and it was followed by functional deficiency of @entity1 . In @entity0 without @entity5 microcytosis and hypochromia of erythrocytes were marked too. The techniques of laboratory diagnostic objectively reflecting @entity1 metabolism (evaluation of level of soluble receptors of @entity2 andferritin) and appropriate hormonal response to degree of @entity4 (production of @entity7 ) are to be included into algorithm of treatment of @entity0 . The purpose is to timely detect type of @entity4 with the purpose of its appropriate correction prior to treatment onset.

title: [The characteristics of @entity5 in @entity0 with prevalent phases of XXXX before treatment].

answer: @entity6


abstract: The study was carried out to analyze peripheral blood covering 23 @entity0 with prevalent phases of @entity6 received no treatment previously. The clinical analysis of blood was implemented using hematologic analyzer Sysmex XE-2100. The content of ferritin, soluble receptors of @entity2 and @entity7 was estimated using enzyme-linked immunosorbent assay. The free hemoglobin was estimated using hemoglobin cyanide method. The direct Coombs test, counting of leukogram and analysis of morphology of erythrocytes were applied to all @entity0 . The @entity4 is diagnosed in 19 @entity0 (83%). In 18 out of them the @entity5 corresponded to @entity4 and in one @entity0 asiderotic @entity4 was established. The rest of @entity0 had no @entity4 . The @entity4 of @entity3 characterized by microcytosis and hypochromia of erythrocytes, inadequate degree of @entity4 by production of @entity7 and functional deficiency of @entity1 in most of the @entity0 . It should be emphasized that @entity4 of @entity3 commonly is normocyte normochrome @entity4 whereas in @entity0 with prevalent phases of Hodgkin Iymphoma the microcyte hypochrome @entity4 was detected before the treatment and it was followed by functional deficiency of @entity1 . In @entity0 without @entity5 microcytosis and hypochromia of erythrocytes were marked too. The techniques of laboratory diagnostic objectively reflecting @entity1 metabolism (evaluation of level of soluble receptors of @entity2 andferritin) and appropriate hormonal response to degree of @entity4 (production of @entity7 ) are to be included into algorithm of treatment of @entity0 . The purpose is to timely detect type of @entity4 with the purpose of its appropriate correction prior to treatment onset.

title: [The characteristics of XXXX in @entity0 with prevalent phases of @entity6 before treatment].

answer: @entity5


abstract: The study was carried out to analyze peripheral blood covering 23 @entity0 with prevalent phases of @entity6 received no treatment previously. The clinical analysis of blood was implemented using hematologic analyzer Sysmex XE-2100. The content of ferritin, soluble receptors of @entity2 and @entity7 was estimated using enzyme-linked immunosorbent assay. The free hemoglobin was estimated using hemoglobin cyanide method. The direct Coombs test, counting of leukogram and analysis of morphology of erythrocytes were applied to all @entity0 . The @entity4 is diagnosed in 19 @entity0 (83%). In 18 out of them the @entity5 corresponded to @entity4 and in one @entity0 asiderotic @entity4 was established. The rest of @entity0 had no @entity4 . The @entity4 of @entity3 characterized by microcytosis and hypochromia of erythrocytes, inadequate degree of @entity4 by production of @entity7 and functional deficiency of @entity1 in most of the @entity0 . It should be emphasized that @entity4 of @entity3 commonly is normocyte normochrome @entity4 whereas in @entity0 with prevalent phases of Hodgkin Iymphoma the microcyte hypochrome @entity4 was detected before the treatment and it was followed by functional deficiency of @entity1 . In @entity0 without @entity5 microcytosis and hypochromia of erythrocytes were marked too. The techniques of laboratory diagnostic objectively reflecting @entity1 metabolism (evaluation of level of soluble receptors of @entity2 andferritin) and appropriate hormonal response to degree of @entity4 (production of @entity7 ) are to be included into algorithm of treatment of @entity0 . The purpose is to timely detect type of @entity4 with the purpose of its appropriate correction prior to treatment onset.

title: [The characteristics of @entity5 in XXXX with prevalent phases of @entity6 before treatment].

answer: @entity0


abstract: AIMS: The role of @entity9 /2-induced @entity5 (PG) in unilateral chronic @entity0 of anesthetized @entity2 was examined. METHODS: @entity1 kidneys were established by reducing renal blood flow of left renal artery to 10% of baseline with an adjustable clip. After 4 weeks, changes in intrarenal contents of @entity4 /PGI2 and angiotensin (Ang) II were evaluated with renal microdialysis and biopsy. Furthermore, the effect of a non-specific COX inhibitor ( @entity10 ), a @entity6 -specific inhibitor ( @entity7 ), and an Ang receptor antagonist ( @entity11 ) on renal function and renal PG contents were evaluated. RESULTS: Unilateral renal artery clipping reduced renal plasma flow (RPF) in clipped (from 59 +/- 2 to 17 +/- 1 ml/min, n = 18) and nonclipped kidneys (from 59 +/- 2 to 44 +/- 2 ml/min) and natriuresis. Intrarenal @entity4 increased only in clipped kidneys (from 114 +/- 7 to 375 +/- 25 pg/ml), whereas @entity8 increased in both kidneys. @entity10 reduced intrarenal PG contents, and decreased RPF, GFR, and urinary @entity3 excretion (UNaV), whereas @entity7 reduced UNaV in clipped (from 4.0 +/- 0.9 to 1.7 +/- 0.2 microEq/min) and nonclipped kidneys (from 5.4 +/- 0.5 to 2.9 +/- 0.3 microEq/min), without affecting renal hemodynamics. Intrarenal Ang II contents increased in clipped (from 0.70 +/- 0.06 to 2.32 +/- 0.33 pg/mg, n = 18) and nonclipped kidneys (from 0.65 +/- 0.06 to 2.45 +/- 0.33 pg/mg, n = 18), and @entity11 improved renal hemodynamics and natriuresis. The elevated intrarenal Ang II content was suppressed by @entity7 only in clipped kidneys. CONCLUSION: Unilateral @entity0 elevates intrarenal @entity4 contents in clipped kidneys, which serves to countervail the aggravation of renal function. Furthermore, intrarenal COX isoforms may play differential roles, with @entity9 participating in modulation of renal hemodynamics, and @entity6 contributing to @entity3 excretion and Ang II formation.

title: Distinct role of intrarenal cyclooxygenase-1/2 in chronic XXXX .

answer: @entity0


abstract: BACKGROUND AND PURPOSE: To review the multiple factors in intermittent @entity2 (X(T)) responsible for the discrepancy between the distance and near deviations; to challenge the classification of X(T) into types according to the two standard clinical tests of occlusion of one eye and the use of +3.00 D spherical lenses at near by demonstrating the pitfalls of these two tests, as in X(T), masquerading as high AC/A ratio at times or as strong proximal fusional convergence at other times. METHODS OF STUDY: Fifteen @entity0 demonstrating findings characteristic of X(T) with so-called high AC/A ratio are reported. Fourteen @entity0 had an @entity2 initially. The fifteenth had become exotropic following medial rectus recessions for infantile @entity3 . Fourteen @entity0 had bilateral lateral rectus recession and one had unilateral lateral rectus recession. RESULTS: The only @entity0 who did develop a long term postoperative overcorrected high AC/A ratio @entity3 was the @entity0 who had initially an infantile @entity3 . Of the other 14 @entity0 @entity1 (T) none developed a long term postoperative overcorrected high AC/A ratio @entity3 . Fifty % of these were "cured" (OT +/- @entity4 ) and 50% had a "significant (> or = @entity4 ) recurrence" of their @entity2 . CONCLUSION: @entity0 with intermittent @entity2 and significantly more @entity2 at distance than at near, and classified to have high AC/A ratio by occlusion of one eye and the use of +3.00 spheres at near, do not necessarily have a high accommodation-convergence relationship but rather, other factors mimicking this high AC/A relationship. They do not necessarily develop a postoperative overcorrected high AC/A ratio @entity3 .

title: Intermittent XXXX with high AC/A ratio: is it a bane to surgical cure? Some facts and fictions of the two clinical tests: occlusion of one eye and the use of +3.00 spherical lenses.

answer: @entity2


abstract: The protein @entity1 phosphatase PTP-Basophil (PTP-Bas) and its @entity0 homologue, @entity4 ( @entity4 ), are high molecular mass protein phosphatases consisting of a number of diverse protein-protein interaction modules. Several splicing variants of these phosphatases are known to exist thus demonstrating the complexity of these molecules. PTP-Bas/BL serves as a central scaffolding protein facilitating the assembly of a multiplicity of different proteins mainly via five different PDZ domains. Many of these interacting proteins are implicated in the regulation of the actin cytoskeleton. However, some proteins demonstrate a nuclear function of this protein @entity1 phosphatase. PTP-Bas is involved in the regulation of cell surface expression of the cell death receptor, Fas. Moreover, it is a negative regulator of ephrinB phosphorylation, a receptor playing an important role during development. The phosphorylation status of other proteins such as RIL, @entity2 and @entity3 can also be regulated by this phosphatase. Finally, @entity4 has been shown to be involved in the regulation of cytokinesis, the last step in cell division. Although the precise molecular function of PTP-Bas/BL is still elusive, current data suggest clearly that PTP-Bas/BL belongs to the family of PDZ domain containing proteins involved in the regulation of the cytoskeleton and of intracellular vesicular transport processes.

title: The protein XXXX phosphatase PTP-Basophil/Basophil-like. Interacting proteins and molecular functions.

answer: @entity1


abstract: BACKGROUND: Prior studies have demonstrated a significant gap between guideline-based recommendations and clinical practice in the management of @entity1 ( @entity1 ) in China. AIMS: This study implements a targeted multifaceted quality improvement intervention in @entity1 @entity0 and identifies the feasibility and efficacy of this intervention. DESIGN: This is a multicenter, 2-arm, open-label, cluster-randomized trial involving 40 clusters (hospitals) from China National Network of @entity1 Research. Hospitals are randomized to receive a targeted multifaceted quality improvement intervention (experimental group) or routine standard of care (control group). The multifaceted intervention includes an evidence-based clinical pathway, written care protocols, a quality coordinator, and a monitoring and feedback system of performance measures. The number of enrolled @entity0 in the trial will be 4,800. Primary outcome is the measure of the adherence to @entity1 evidence-based performance measures including the composite measure (defined as the total number of interventions performed among eligible @entity0 divided by the total number of possible interventions among eligible @entity0 ) and the all-or-none measure (defined as the proportion of eligible @entity0 who receive all of the performance measure interventions for which they are eligible). Secondary @entity0 outcomes include @entity2 ; a new vascular event; disability; and all-cause @entity2 at 3, 6, and 12 months after initial symptom onset. All analyses will be performed according to the intention-to-treatment principle and accounted for clustering using generalized estimating equations. CONCLUSIONS: If proven effective, this targeted multifaceted intervention model will be extended nationwide as a model to bridge the evidence-based gap in the @entity1 management in China.

title: Rationale and design of a cluster-randomized multifaceted intervention trial to improve XXXX care quality in China: The GOLDEN BRIDGE-Acute Ischemic Stroke.

answer: @entity1


abstract: Gatherings of large numbers of @entity0 at concerts, sporting events, and other occasions lead to an assembled population with a potential for a wide variety of illnesses and injuries. The collection of large numbers of @entity0 in a single location has led some authors to recommend the placement of resuscitation equipment or other medical services in close proximity to these activities. These recommendations not withstanding, data on the frequency of @entity5 at mass gatherings (a group exceeding 1000 @entity0 ) are difficult to ascertain. Therefore, it was the purpose of this study to describe the incidence of @entity5 among assembled populations at mass gatherings. An observational prospective study was conducted involving @entity0 encounters at a large, multipurpose, indoor mass-gathering complex in Houston, Texas occurring between September 1, 1996 and June 30, 1997. Demographic, treatment, disposition and diagnostic data were analyzed in a computerized database. Of the 3.3 million attendants to the 253 events analyzed during the 10-month study period, there were 2762 (0.08%) @entity0 encounters. Fifty-two percent were @entity0 . Mean age was 32 +/- 15.6 years. Of these @entity0 , 51.1% were patrons and the remaining @entity0 were employees or contractors of the facility. A wide variety of illness was seen with @entity2 (39.5%), @entity1 (31%), and other medical complaints (29.5%) being most frequent. Disposition of the @entity0 included 95.3% being discharged to go back to the event and 2.2% being counseled to seek other medical attention. One hundred twenty-nine @entity0 (4.7%) were referred to the @entity3 ( @entity3 ); of these, 70 were transferred for abrasions, lacerations, or skeletal injuries and 13 for @entity4 . Of those referred to the @entity3 , 50 (38.7%) @entity0 were transported by ambulance and only 17.4% were admitted to telemetry, with none admitted to an ICU. It is concluded that @entity5 at mass gatherings is infrequent, as seen in this study, with very few being admitted to telemetry and none to an ICU. Careful consideration of cost-benefit should occur when determining allocation of resources for these activities.

title: XXXX at mass gatherings is uncommon.

answer: @entity5


abstract: BACKGROUND: Clinical evidence suggests that platelet concentrate (PC) could have beneficial therapeutic effects on hard and soft tissue healing, due to the contents of growth factors (GFs) stored in the platelets. The objectives of this study were: 1) to determine the concentrations of platelet-derived growth factor-BB (PDGF-BB), @entity5 ( @entity5 ), @entity1 ( @entity1 ), and @entity3 ( @entity3 ) released from PCs and whole blood (WB), before and after the addition of various concentrations of @entity2 and @entity4 ) to assess the physiological importance of the released GFs on angiogenesis. METHODS: WB and PCs were harvested and prepared from three healthy volunteers. Enzyme-linked immunosorbent assay tests, specific for PDGF-BB, @entity5 , @entity1 , and @entity3 , were performed on WB and PC supernatants, collected before and 30 minutes after the addition of various concentrations of @entity2 and @entity4 . The supernatants were also added to @entity0 umbilical vein endothelial cell (HUVEC) cultures in order to measure their effects on endothelial cell proliferation. RESULTS: Growth factor concentrations detected in PC supernatants were significantly greater (280% to 800% increase) than concentrations present in WB supernatants. @entity2 and @entity4 induced immediate GF release from PCs in a dose-dependent fashion. Furthermore, PC supernatants led to greater HUVEC proliferation rates than WB supernatants. However, there was no correlation between the concentrations of specific GFs and HUVEC proliferation rates. CONCLUSION: These results suggest that PCs could stimulate blood vessel formation. They also reinforce the relevance for using PCs in regenerative therapies.

title: Platelet concentrates: effects of XXXX and @entity4 on endothelial cell proliferation and growth factor release.

answer: @entity2


abstract: BACKGROUND: Clinical evidence suggests that platelet concentrate (PC) could have beneficial therapeutic effects on hard and soft tissue healing, due to the contents of growth factors (GFs) stored in the platelets. The objectives of this study were: 1) to determine the concentrations of platelet-derived growth factor-BB (PDGF-BB), @entity5 ( @entity5 ), @entity1 ( @entity1 ), and @entity3 ( @entity3 ) released from PCs and whole blood (WB), before and after the addition of various concentrations of @entity2 and @entity4 ) to assess the physiological importance of the released GFs on angiogenesis. METHODS: WB and PCs were harvested and prepared from three healthy volunteers. Enzyme-linked immunosorbent assay tests, specific for PDGF-BB, @entity5 , @entity1 , and @entity3 , were performed on WB and PC supernatants, collected before and 30 minutes after the addition of various concentrations of @entity2 and @entity4 . The supernatants were also added to @entity0 umbilical vein endothelial cell (HUVEC) cultures in order to measure their effects on endothelial cell proliferation. RESULTS: Growth factor concentrations detected in PC supernatants were significantly greater (280% to 800% increase) than concentrations present in WB supernatants. @entity2 and @entity4 induced immediate GF release from PCs in a dose-dependent fashion. Furthermore, PC supernatants led to greater HUVEC proliferation rates than WB supernatants. However, there was no correlation between the concentrations of specific GFs and HUVEC proliferation rates. CONCLUSION: These results suggest that PCs could stimulate blood vessel formation. They also reinforce the relevance for using PCs in regenerative therapies.

title: Platelet concentrates: effects of @entity2 and XXXX on endothelial cell proliferation and growth factor release.

answer: @entity4


abstract: INTRODUCTION: @entity1 registries capture valid information at the time of @entity1 diagnosis, but often do not conduct longitudinal follow-up evaluations. However, investigators may be interested in questions relating to subsequent relapsed disease. Linking administrative data to registry data, as in the creation of the SEER (Surveillance, Epidemiology, and End Results) and Medicare data set, can provide the ability to infer the occurrence of relapse in selected situations. METHODS: The authors created different algorithms to detect relapse of @entity2 ( @entity2 ). A retrospective cohort of @entity0 with @entity2 was identified, and both their billing data and medical records were obtained. The algorithms were then applied to the billing data, the results were compared with medical record review. RESULTS: Eighty-nine @entity0 were identified, of whom 22 were treated for relapsed @entity2 . The sensitivity of the best algorithm for detecting relapse was 86%, and the specificity 99%, with a positive predictive value of 95% and a negative predictive value of 96%. CONCLUSIONS: Identification of relapse from SEER-Medicare data using clinical algorithms is feasible for @entity1 where a majority of @entity0 receive treatment for relapse, without a "watch and wait" strategy, and where that treatment is with a modality that can be detected in billing data (ie, intravenous chemotherapy, radiation, surgery, or all three). Optimal analytic situations are ones in which the investigator is mostly interested in positive predictive value, less interested in sensitivity, and wants to evaluate outcomes among those @entity0 who receive treatment for their relapsed disease. However, the accuracy of such an approach for @entity1 other than @entity2 has not yet been established.

title: Identifying XXXX relapse using SEER-Medicare data.

answer: @entity1


abstract: PURPOSE: We present our long-term experience with intravesical @entity4 ( @entity4 ) for primary @entity2 . MATERIALS AND METHODS: The study included 4 males and 2 females 28 to 68 years old (mean age 54) at diagnosis of biopsy proven primary @entity3 involving the bladder diffusely or extensively in 1 locale. All @entity0 had normal upper urinary tracts. They continued to be symptomatic ( @entity1 in 3, irritative voiding symptoms in 1, and @entity1 and irritative voiding symptoms in 2) despite conventional transurethral destructive therapy. Every 2 weeks they received 30-minute instillations of 50 ml. 50% @entity4 intravesically for 3 months ( @entity0 1), 6 months (1) and 1 year (4). RESULTS: Therapy failed at 3 and 6 months in 2 @entity0 of whom 1 with a contracted bladder underwent cystectomy and another was stabilized for 1 year with laser therapy. In the remaining 4 @entity0 who were followed for 6 years disease stabilized for 2 to 6 years (mean 3.5) but 3 later required additional therapy including repeat @entity4 in 1 and laser therapy in 2. CONCLUSIONS: Diffuse or locally extensive @entity2 by primary @entity3 usually fails to respond to conventional transurethral destructive surgical procedures. Collectively, our experience and the literature suggest that intravesical @entity4 can be a bladder saving measure and help resolve @entity5 in some @entity0 . High recurrence rate mandates lifelong cystoscopic surveillance.

title: Primary XXXX : experience with @entity4 therapy.

answer: @entity2


abstract: PURPOSE: We present our long-term experience with intravesical @entity4 ( @entity4 ) for primary @entity2 . MATERIALS AND METHODS: The study included 4 males and 2 females 28 to 68 years old (mean age 54) at diagnosis of biopsy proven primary @entity3 involving the bladder diffusely or extensively in 1 locale. All @entity0 had normal upper urinary tracts. They continued to be symptomatic ( @entity1 in 3, irritative voiding symptoms in 1, and @entity1 and irritative voiding symptoms in 2) despite conventional transurethral destructive therapy. Every 2 weeks they received 30-minute instillations of 50 ml. 50% @entity4 intravesically for 3 months ( @entity0 1), 6 months (1) and 1 year (4). RESULTS: Therapy failed at 3 and 6 months in 2 @entity0 of whom 1 with a contracted bladder underwent cystectomy and another was stabilized for 1 year with laser therapy. In the remaining 4 @entity0 who were followed for 6 years disease stabilized for 2 to 6 years (mean 3.5) but 3 later required additional therapy including repeat @entity4 in 1 and laser therapy in 2. CONCLUSIONS: Diffuse or locally extensive @entity2 by primary @entity3 usually fails to respond to conventional transurethral destructive surgical procedures. Collectively, our experience and the literature suggest that intravesical @entity4 can be a bladder saving measure and help resolve @entity5 in some @entity0 . High recurrence rate mandates lifelong cystoscopic surveillance.

title: Primary @entity2 : experience with XXXX therapy.

answer: @entity4


abstract: PURPOSE: We designed an investigational study and placebo controlled trial to evaluate the efficacy of magnetic stimulation of the sacral roots for treating urinary frequency and urge @entity1 . MATERIALS AND METHODS: A total of 48 @entity0 43 to 75 years old (mean age 61) with the complaint of urinary frequency and/or urge @entity1 were studied. We applied 15 Hz. repetitive magnetic stimulation of the sacral roots with 50% intensity output for 5 seconds per minute for 30 minutes. Urodynamic investigations during magnetic stimulation were performed in 11 cases to evaluate acute effects for lowering urinary tract function. Another 37 @entity0 were enrolled in a placebo controlled study to investigate short-term effects. The mean number of voids daily, mean urine volume per void, number of leaks for 3 days and quality of life score were evaluated before and 1 week after stimulation. RESULTS: Urodynamic investigations revealed apparent elevation in mean maximum urethral closure pressure plus or minus standard deviation during stimulation in all 11 cases (8.4 +/- 3.6 cm. water, p = 0.00001) and a significant increase in mean bladder capacity after stimulation (58.2 +/- 50.2 ml., p = 0.003). In the placebo controlled study all parameters significantly improved in the active stimulation group. Intergroup comparison showed that mean urine volume per void, mean number of leaks and mean quality of life score improved more significantly in the active than in the sham stimulation group (23.5 +/- 25.6 ml. versus 6.2 +/- 22.5, p = 0.04, 3.6 +/- 4.1 versus 0.4 +/- 1.4, p = 0.04 and 1.4 +/- 1.3 versus 0.4 +/- 0.8, p = 0.01, respectively). No adverse effects were noted in any @entity0 . CONCLUSIONS: These results suggest that magnetic stimulation of the sacral roots may be useful for treating urinary frequency and urge @entity1 .

title: Magnetic stimulation of the sacral roots for the treatment of urinary frequency and urge XXXX : an investigational study and placebo controlled trial.

answer: @entity1


abstract: BACKGROUND: Cereals are among the major foods that account for @entity1 reactions. Salt-soluble proteins appear to be the most important allergens contributing to the @entity8 response. In contrast, very limited information is available regarding cereal allergens responsible for @entity1 after ingestion of cereal proteins. OBJECTIVE: The aim of this study was to evaluate the allergenic reactivity of ingested and inhaled cereal allergens in different ages, in order to investigate if the response to different allergens would depend on the sensitization route. METHODS: We included 66 @entity0 in three groups. Group 1: 40 @entity0 aged 3 to 6 months who suffered from @entity3 , @entity5 , @entity6 or @entity4 after the introduction of cereal formula in their diet and in which a possibility of @entity2 was discarded. Group 2: 18 adults with @entity12 due to cereals tested by prick tests, specific IgE and food challenge. Group 3: eight @entity0 previously diagnosed as having @entity13 . Sera pool samples were collected from each group of @entity0 and IgE immunoblotting was performed. RESULTS: We found an important sensitization to cereal in the 40 @entity0 . The most important allergens were @entity10 followed by @entity9 and rye. Among the adults with @entity7 , sensitization to other allergens was common, especially to @entity11 (rye grass) pollen. Immunoblotting showed similar allergenic detection in the three groups. CONCLUSION: Clinically significant reactivity to cereal may be observed in early life. Inhalation and ingestion routes causing @entity7 seem to involve similar allergens. The diet control was more effective in @entity0 . The possibility of @entity7 after the introduction of cereal formula during the lactation period should not be underestimated.

title: XXXX after ingestion or inhalation of cereals involves similar allergens in different ages.

answer: @entity7


abstract: BACKGROUND: The choice of surgical strategy for @entity0 with @entity4 of the oesophagogastric junction is controversial. This study was performed to analyse the surgical results of a 20-year experience with these lesions. METHODS: From January 1981 to January 2001, 126 @entity0 with @entity4 underwent resection in the authors' institution. The treatment of choice was oesophagectomy for @entity1 , and extended gastrectomy for @entity2 . Morbidity, mortality and survival were determined retrospectively. RESULTS: Fifty-six @entity0 (44.4 per cent) had @entity1 , 44 (34.9 per cent) type II and 26 (20.6 per cent) type III. Primary resection was performed in 113 @entity0 (89.7 per cent). Oesophagectomy with resection of the proximal stomach was carried out in 65 @entity0 (51.6 per cent) and extended total gastrectomy with transhiatal resection of the distal oesophagus in 61 (48.4 per cent). In-hospital mortality and morbidity rates were 4.8 and 34.1 per cent respectively. The overall 3- and 5-year survival rates were 40.9 and 25.1 per cent respectively, and were not affected by the surgical approach. Survival was significantly associated with R0 resection, pathological node-positive category, @entity3 and @entity1 differentiation. CONCLUSION: Postoperative mortality, morbidity and long-term survival did not appear to be affected by surgical approach. Further prospective studies are needed to confirm the equivalence between transthoracic and transabdominal approaches.

title: Surgical management of and long-term survival after XXXX .

answer: @entity4


abstract: BACKGROUND: Cognitive variables such as negative self-evaluations have been discussed as vulnerability factors for @entity2 . In the context of @entity1 dysfunctional cognitive structures have received little interest as these @entity0 seem to be less disturbed during the euthymic interval than @entity0 with @entity2 . METHODS: In the present study, the self-esteem of remitted @entity0 with DSM-III-R diagnosis of @entity2 (n=20), @entity1 (n=20) and healthy controls (n=20) was measured with the Frankfurt Self-concept Scale (FSKN). RESULTS: 1) Statistical analysis by analysis of variance (ANOVA) showed no significant differences as to age, sex, etc. between the psychiatric groups. The clinical groups showed lower self-esteem ratings in comparison to healthy controls. 2) Four groups (T1-T4) of remitted @entity0 with @entity1 (20 in each group) were successfully maintained on mood stabilizers ( @entity3 or @entity4 ) and classified by the duration of their episode-free period. T1 included those who were episode-free for only the week before discharge from hospital. T2 were symptom-free for <30 months. T3 were episode-free for >30 months and <60 months. T4 were episode-free for >60 months. The comparison of their FSKN self-esteem ratings by ANOVA suggests that self-esteem improves during successful prophylactic treatment. A posteriori contrasts indicate a normalized self-esteem after a bipolar episode-free period of at least 47 months. CONCLUSIONS: Dysfunctional cognitions can be demonstrated in unipolar as well as in bipolar @entity0 . Successful episode-preventive medication with mood stabilizers seems to counteract lowered self-esteem. Adjunctive cognitive therapy might help to optimize the long-term course of @entity1 .

title: The influence of successful prophylactic drug treatment on cognitive dysfunction in XXXX .

answer: @entity1


abstract: Augmentation mammaplasty has become more popular in Taiwan. Therefore, clinical imaging is necessary to evaluate those @entity1 who develop @entity0 . The purpose of this study was to evaluate the detection of @entity3 after augmentation mammaplasty by means of mammography and sonography. A retrospective follow-up study and analysis of diagnostic methods including mammography, sonography, physical examination, and aspiration cytology was conducted on 105 @entity1 who underwent augmentation mammaplasty at Kaohsiung Medical University Hospital between 1989 and 2001. A total of 105 @entity1 were identified in this study, and mean follow-up was 4 years. Two @entity2 from 8 @entity2 @entity1 were visible on standard mammograms, and seven @entity2 were diagnosed as @entity2 by sonography. One of 15 @entity0 was interpreted as a suspected @entity2 , and 7 @entity2 were interpreted as normal findings on mammograms. Fourteen of 15 @entity0 were diagnosed correctly except for one suspicious case examined by sonography. Sonography showed the highest rate of diagnostic accuracy (91.3%) and mammograms had the lowest rate (73.9%). The accuracy rate of physical examination was 73.9%, and aspiration cytology was 90.0% accurate. This study affirms that sonography is a more useful diagnostic tool than mammography in Taiwanese @entity1 who have undergone augmentation mammaplasty.

title: Comparison between sonography and mammography for XXXX diagnosis in oriental @entity1 after augmentation mammaplasty.

answer: @entity0


abstract: Augmentation mammaplasty has become more popular in Taiwan. Therefore, clinical imaging is necessary to evaluate those @entity1 who develop @entity0 . The purpose of this study was to evaluate the detection of @entity3 after augmentation mammaplasty by means of mammography and sonography. A retrospective follow-up study and analysis of diagnostic methods including mammography, sonography, physical examination, and aspiration cytology was conducted on 105 @entity1 who underwent augmentation mammaplasty at Kaohsiung Medical University Hospital between 1989 and 2001. A total of 105 @entity1 were identified in this study, and mean follow-up was 4 years. Two @entity2 from 8 @entity2 @entity1 were visible on standard mammograms, and seven @entity2 were diagnosed as @entity2 by sonography. One of 15 @entity0 was interpreted as a suspected @entity2 , and 7 @entity2 were interpreted as normal findings on mammograms. Fourteen of 15 @entity0 were diagnosed correctly except for one suspicious case examined by sonography. Sonography showed the highest rate of diagnostic accuracy (91.3%) and mammograms had the lowest rate (73.9%). The accuracy rate of physical examination was 73.9%, and aspiration cytology was 90.0% accurate. This study affirms that sonography is a more useful diagnostic tool than mammography in Taiwanese @entity1 who have undergone augmentation mammaplasty.

title: Comparison between sonography and mammography for @entity0 diagnosis in oriental XXXX after augmentation mammaplasty.

answer: @entity1


abstract: The monoclonal antibody HISL-19 was originally generated after immunizing BALB/c @entity2 with @entity0 islet cells. We used this antibody to study a wide variety of neuroendocrine (NE) and non-NE @entity1 by immunohistochemical, immunoelectron microscopic, and biochemical (Western blotting) techniques. Of the @entity4 , HISL-19 specifically immunoreacted with @entity3 of the thyroid (MCT); of the @entity5 , it reacted with @entity7 and a @entity8 ; of the @entity1 , it reacted with @entity6 . HISL-19 showed particularly strong immunoreactivity to a gross granular material at the perinuclear area in the MCT and @entity1 but not in the benign @entity6 , although the latter cells showed a faint and homogenous positive reactivity in the cytoplasm. The strongly HISL-19-positive material was found to consist of newly synthesized antigenic proteins with a molecular weight between 60 and 65 kilodaltons (kDa) by Western blotting. Immunoelectron microscopic analysis revealed that this antigenic protein was located in the secretory granules that appear markedly in @entity1 , usually located close to the nucleus. Thus, HISL-19 is a useful and specific marker for the immunohistochemical diagnosis of NE cell @entity1 . The specific antigenic proteins of HISL-19 were defined in MCT and @entity1 . These proteins are speculated to be actively synthesized and more highly produced in the secretory granules of @entity1 than benign ones. Thus, a preoperative immunohistochemical study using HISL-19 might be useful for predicting the grade of @entity1 and thus help determine an appropriate operative procedure, in addition to being a useful marker of @entity9 .

title: Immunohistochemical, biochemical and immunoelectron microscopic analysis of antigenic proteins on XXXX using monoclonal antibody HISL-19.

answer: @entity9


abstract: @entity13 is a very uncommon @entity1 (<1% of @entity5 ) characterized by severe local course and rapid metastatic dissemination and very poor prognosis. We report the case of an 84-year-old @entity0 hospitalized for expiratory @entity10 , severe @entity11 and @entity9 leading to @entity6 . She had a voluminous (20 cm) extra-thoracic @entity12 with a considerable superficial venous pattern that had developed on an old @entity12 before growing recently. @entity7 and @entity3 levels were normal. The cervical-thoracic CT demonstrated a partially necrosed heterogeneously hypodense @entity1 compressing the esophagus and the @entity8 with displacement of adjacent structures which were not directly invaded. Large areas of @entity2 and a probable metastatic image measuring 3 cm in the right median pulmonary lobe were observed. Macrobiopsy disclosed grade 3 @entity4 . Complete resection delivered a 3.170 kg @entity1 . Histology confirmed the diagnosis of @entity4 without neoplastic extension. Apart from right recurrent palsy, the initial post-operative period was satisfactory and the @entity0 was discharged. Four and a half months later she was rehospitalized with local recurrence with a large metastatis in the right lung. She died two weeks later.

title: XXXX : a case report.

answer: @entity13


abstract: PURPOSE: The metabolic peturbations of @entity2 cause functional and structural changes in the retinal microvasculature which are termed @entity2 . Exposure of the eye to ionising @entity5 results in @entity4 with a clinical manifestation known as @entity4 . Anecdotal studies have suggested that exposure to even low levels of ionising @entity5 may accelerate development of pathological changes in the retinal vessels of @entity0 with @entity2 . This in vitro study was designed to test the hypothesis that the combination of a high ambient @entity3 environment (mimicking hyperglycaemia and @entity2 ) along with exposure to ionising @entity5 would result in more accentuated damage to cultured @entity4 . METHODS: Retinal microvascular endothelial cells and pericytes were propagated for 5 days in either 5 mM (euglycaemia) or 15 mM (hyperglycaemia) @entity3 . Cells were irradiated with 250, 500 or 1000 cGy of ionising @entity5 using a 6 MV beam photon accelerator which was used for radiotherapy. Similarly treated but unirradiated cells were used as controls. DNA damage was assessed using the single-cell gel electrophoresis (comet) assay. RESULTS: Unirradiated control cells pre-exposed to @entity3 at either 5 mM or 15 mM for 5 days showed no significant difference in mean percentage tail DNA representing damage. However, in both pericytes and endothelial cells exposed to ionising @entity5 , cells cultured in 15 mM @entity3 showed significantly higher levels of DNA damage compared with those cultured in 5 mM @entity3 , with maximal differences being seen at the higher @entity5 doses (500 and 1000 cGy). CONCLUSIONS: This study has demonstrated that retinal microvascular cells cultured in high @entity3 express more DNA damage when exposed ionising @entity5 . These findings have important implications for the management of @entity0 with @entity2 if they require radiotherapy for @entity1 .

title: The effects of high ambient XXXX on the radiosensitivity of retinal microvascular endothelial cells and pericytes.

answer: @entity3


abstract: AIMS: To evaluate the role of the superior rectus bridle suture in the development of post @entity2 . METHODS: We compared the incidence of @entity1 in two groups of @entity0 undergoing @entity2 extraction. In the first group (32 @entity0 ), a temporal corneal approach was employed with no superior rectus bridle suture. In the second group (38 @entity0 ), a superior approach with a bridle suture was used. Both groups of @entity0 underwent phacoemulsification with the use of peribulbar anaesthesia, a pressure lowering device and a speculum. We recorded the lid position at least 12 weeks following surgery and determined the degree of @entity1 . Two-sided Fischer's Exact Test was used to test for significant difference between the two groups (using a statistical software package Instat Version 3.0 for Windows). RESULTS: Taking 2 mm of @entity3 as a significant change, 11.5% of those undergoing temporal section sustained @entity1 whilst it occurred in 12.9% of those who underwent a superior approach. CONCLUSIONS: The presence or absence of the superior rectus bridle suture and the site of the ocular wound do not significantly contribute to the incidence of @entity1 . We would suggest that the causative factors are peribulbar anaesthesia, a pressure lowering device and the use of the speculum.

title: XXXX --the bridle suture factor?

answer: @entity3


abstract: PURPOSE: To survey clinical visual function including quantitative manual perimetry results in a group of @entity0 taking @entity5 ; to assess the severity of any field defects; to tabulate cumulative and daily doses of medication and to assess possible changes in visual function over time. METHOD: A prevalence study of 100 out of 183 @entity0 currently attending a tertiary referral @entity3 centre who were taking or had recently discontinued @entity5 (duration 83-3570 days; mean 1885 days) as part of combination anticonvulsant therapy. Complete neuro-ophthalmic examination including Goldmann kinetic perimetry was performed and monocular @entity4 ( @entity4 ) to the I/4e isopter calculated. @entity0 were followed up at 6-monthly intervals for not less than 18 months. RESULTS: Acuity and colour vision remained stable in all @entity0 regardless of changes in visual fields. Twenty per cent of @entity0 had significant constriction of their visual field defined as a monocular @entity4 of 30 degrees or less. Males were significantly more likely to be severely affected than females (P < 0.01). Twenty one @entity0 were followed after discontinuing @entity5 treatment. Only three of these showed a change in @entity4 of 10 degrees or more with two deteriorating and one improving. No correlation between treatment duration or cumulative dosage/kg and the severity of defects could be demonstrated. CONCLUSIONS: Earlier reports of a high prevalence of both moderate and more serious field defects were confirmed in @entity0 taking @entity5 but not in @entity3 @entity0 taking other anti-convulsants. We found no evidence of progression or resolution of @entity2 on discontinuing the drug, and no relationship between dose history and @entity2 . An @entity1 retina may underlie the pathogenesis of the @entity2 in some @entity0 .

title: @entity5 associated XXXX : a clinical audit to study prevalence, drug history and effects of drug withdrawal.

answer: @entity2


abstract: PURPOSE: To survey clinical visual function including quantitative manual perimetry results in a group of @entity0 taking @entity5 ; to assess the severity of any field defects; to tabulate cumulative and daily doses of medication and to assess possible changes in visual function over time. METHOD: A prevalence study of 100 out of 183 @entity0 currently attending a tertiary referral @entity3 centre who were taking or had recently discontinued @entity5 (duration 83-3570 days; mean 1885 days) as part of combination anticonvulsant therapy. Complete neuro-ophthalmic examination including Goldmann kinetic perimetry was performed and monocular @entity4 ( @entity4 ) to the I/4e isopter calculated. @entity0 were followed up at 6-monthly intervals for not less than 18 months. RESULTS: Acuity and colour vision remained stable in all @entity0 regardless of changes in visual fields. Twenty per cent of @entity0 had significant constriction of their visual field defined as a monocular @entity4 of 30 degrees or less. Males were significantly more likely to be severely affected than females (P < 0.01). Twenty one @entity0 were followed after discontinuing @entity5 treatment. Only three of these showed a change in @entity4 of 10 degrees or more with two deteriorating and one improving. No correlation between treatment duration or cumulative dosage/kg and the severity of defects could be demonstrated. CONCLUSIONS: Earlier reports of a high prevalence of both moderate and more serious field defects were confirmed in @entity0 taking @entity5 but not in @entity3 @entity0 taking other anti-convulsants. We found no evidence of progression or resolution of @entity2 on discontinuing the drug, and no relationship between dose history and @entity2 . An @entity1 retina may underlie the pathogenesis of the @entity2 in some @entity0 .

title: XXXX associated @entity2 : a clinical audit to study prevalence, drug history and effects of drug withdrawal.

answer: @entity5


abstract: Dynamic MR imaging provides hemodynamic information about normal and pathologic tissue of the brain. The purpose of our study was to evaluate the usefulness of dynamic MR imaging in the assessment of @entity1 vascularity and the @entity1 tissue blood flow of @entity2 . We studied 13 @entity0 with @entity2 using dynamic spin-echo MR imaging. The histological subtypes of @entity2 were confirmed by the examination of surgical specimens in all @entity0 , and @entity1 were meningothelial in 9 cases, fibrous in 2, transitional in 1, and psammomatous in 1. Serial images were obtained every 18-24 sec for 8 minutes and 30 seconds after rapid injection of @entity3 . Different parameters (time to peak, maximum of signal intensity and the washout ratio) were calculated directly from signal intensity curves. As an indicator of @entity1 vascularity, microvessel density was counted based on immunohistochemically stained sections and @entity1 tissue blood flow was measured using an xenon-CT system. The maximum of signal intensity corresponded to the @entity1 vascularity. With dynamic MR imaging, the time intensity curves (TI curves) were divided into two patterns; type 1 had a steep increase with a peak and type 2 had a slow increase to a peak followed by plateau. The maximum of signal intensity measured from TI curve of dynamic MR imaging correlated significantly with microvessel density (R2 = 0.840, p < 0.0001). Linear regression revealed a significant positive relation between the washout ratio and the @entity1 tissue blood flow in group showed type 1 on TI curve (R2 = 0.961, p < 0.001). There was also a significant negative correlation between the time to peak and the @entity1 tissue blood flow (R2 = 0.792, p < 0.01). We suggest that dynamic MR imaging is useful for evaluating hemodynamics of @entity2 .

title: [Assessment of hemodynamics of XXXX with dynamic MR imaging].

answer: @entity2


abstract: Tissues from @entity2 were screened by PCR for the presence of sequences homologous to known adeno-associated virus (AAV) serotypes 1-6. DNA spanning entire rep-cap ORFs from two novel AAVs, called AAV7 and AAV8, were isolated. Sequence comparisons among these and previously described AAVs revealed the greatest divergence in capsid proteins. AAV7 and AAV8 were not neutralized by heterologous antisera raised to the other serotypes. Neutralizing antibodies to AAV7 and AAV8 were rare in human serum and, when present, were low in activity. Vectors formed with capsids from AAV7 and AAV8 were generated by using rep and inverted terminal repeats (ITRs) from @entity3 and were compared with similarly constructed vectors made from capsids of @entity4 , @entity3 , and @entity4 . @entity1 models of skeletal muscle and liver-directed gene transfer were used to evaluate relative vector performance. AAV7 vectors demonstrated efficiencies of transgene expression in skeletal muscle equivalent to that observed with @entity4 , the most efficient known serotype for this application. In liver, transgene expression was 10- to 100-fold higher with AAV8 than observed with other serotypes. This improved efficiency correlated with increased persistence of vector DNA and higher number of transduced hepatocytes. The efficiency of AAV8 vector for liver-directed gene transfer of factor IX was not impacted by preimmunization with the other AAV serotypes. Vectors based on these novel, nonhuman primate AAVs should be considered for @entity0 gene therapy because of low reactivity to antibodies directed to @entity0 AAVs and because gene transfer efficiency in muscle was similar to that obtained with the best known serotype, whereas, in liver, gene transfer was substantially higher than previously described.

title: Novel adeno-associated viruses from XXXX as vectors for @entity0 gene therapy.

answer: @entity2


abstract: Tissues from @entity2 were screened by PCR for the presence of sequences homologous to known adeno-associated virus (AAV) serotypes 1-6. DNA spanning entire rep-cap ORFs from two novel AAVs, called AAV7 and AAV8, were isolated. Sequence comparisons among these and previously described AAVs revealed the greatest divergence in capsid proteins. AAV7 and AAV8 were not neutralized by heterologous antisera raised to the other serotypes. Neutralizing antibodies to AAV7 and AAV8 were rare in human serum and, when present, were low in activity. Vectors formed with capsids from AAV7 and AAV8 were generated by using rep and inverted terminal repeats (ITRs) from @entity3 and were compared with similarly constructed vectors made from capsids of @entity4 , @entity3 , and @entity4 . @entity1 models of skeletal muscle and liver-directed gene transfer were used to evaluate relative vector performance. AAV7 vectors demonstrated efficiencies of transgene expression in skeletal muscle equivalent to that observed with @entity4 , the most efficient known serotype for this application. In liver, transgene expression was 10- to 100-fold higher with AAV8 than observed with other serotypes. This improved efficiency correlated with increased persistence of vector DNA and higher number of transduced hepatocytes. The efficiency of AAV8 vector for liver-directed gene transfer of factor IX was not impacted by preimmunization with the other AAV serotypes. Vectors based on these novel, nonhuman primate AAVs should be considered for @entity0 gene therapy because of low reactivity to antibodies directed to @entity0 AAVs and because gene transfer efficiency in muscle was similar to that obtained with the best known serotype, whereas, in liver, gene transfer was substantially higher than previously described.

title: Novel adeno-associated viruses from @entity2 as vectors for XXXX gene therapy.

answer: @entity0


abstract: BACKGROUND: @entity5 from @entity6 is a life-threatening complication of portal @entity2 . Fundal and isolated @entity6 are at high risk for @entity5 . In this study, we report our experience with @entity8 (BC) in @entity0 with large @entity6 . STUDY: twenty-nine @entity0 (15 male, 14 female) with large fundal varices (active bleed, 5; passive bleed after eradication of esophageal varices, 13; unbled fundal varices with red color sign, 11) underwent endoscopic sclerotherapy with BC. @entity1 was present in 13 @entity0 ; extrahepatic portal @entity4 , in 13; and noncirrhotic portal @entity1 , in 3. @entity8 after mixing with @entity7 (1:1) was given to the initial 10 @entity0 and was given in undiluted form to the remaining @entity0 , followed by injection of 0.7 mL of distilled water to rinse the injection catheter. One to three injections (0.5-1 mL) were given until all @entity6 became hard. All @entity0 were on long-term endoscopic sclerotherapy or variceal ligation programs for eradication of esophageal varices. RESULTS: acute @entity5 was controlled in all five @entity0 with BC injections. Eradication of @entity6 was achieved in 27 (93.1%) @entity0 (20 @entity0 in 1 session, 4 @entity0 in 2, and 3 @entity0 in 3-6). Rebleeding occurred in three (10.3%) @entity0 who responded to repeat BC injections. Complications related to the procedure occurred in two (6.9%) @entity0 . In one @entity0 , the needle became impacted into the tissue adhesive. This @entity0 died 5 days later because of massive @entity3 . In the other @entity0 , there was distal embolization. CONCLUSIONS: sclerotherapy of @entity6 with BC is a safe and an effective treatment for control of @entity5 and eradication. The needle should be withdrawn immediately after the BC injection to prevent its impaction into the tissue adhesive.

title: Endoscopic sclerotherapy of gastric @entity5 with XXXX .

answer: @entity8


abstract: BACKGROUND: @entity5 from @entity6 is a life-threatening complication of portal @entity2 . Fundal and isolated @entity6 are at high risk for @entity5 . In this study, we report our experience with @entity8 (BC) in @entity0 with large @entity6 . STUDY: twenty-nine @entity0 (15 male, 14 female) with large fundal varices (active bleed, 5; passive bleed after eradication of esophageal varices, 13; unbled fundal varices with red color sign, 11) underwent endoscopic sclerotherapy with BC. @entity1 was present in 13 @entity0 ; extrahepatic portal @entity4 , in 13; and noncirrhotic portal @entity1 , in 3. @entity8 after mixing with @entity7 (1:1) was given to the initial 10 @entity0 and was given in undiluted form to the remaining @entity0 , followed by injection of 0.7 mL of distilled water to rinse the injection catheter. One to three injections (0.5-1 mL) were given until all @entity6 became hard. All @entity0 were on long-term endoscopic sclerotherapy or variceal ligation programs for eradication of esophageal varices. RESULTS: acute @entity5 was controlled in all five @entity0 with BC injections. Eradication of @entity6 was achieved in 27 (93.1%) @entity0 (20 @entity0 in 1 session, 4 @entity0 in 2, and 3 @entity0 in 3-6). Rebleeding occurred in three (10.3%) @entity0 who responded to repeat BC injections. Complications related to the procedure occurred in two (6.9%) @entity0 . In one @entity0 , the needle became impacted into the tissue adhesive. This @entity0 died 5 days later because of massive @entity3 . In the other @entity0 , there was distal embolization. CONCLUSIONS: sclerotherapy of @entity6 with BC is a safe and an effective treatment for control of @entity5 and eradication. The needle should be withdrawn immediately after the BC injection to prevent its impaction into the tissue adhesive.

title: Endoscopic sclerotherapy of gastric XXXX with @entity8 .

answer: @entity5


abstract: OBJECTIVE: To determine the feasibility of surgically correcting @entity9 and @entity1 in adult @entity0 . SUMMARY BACKGROUND DATA: Although pectus @entity6 are common, many @entity0 progress to adulthood without surgical repair and experience increasing symptoms. There are sparse published data regarding repair of @entity1 in adults. METHODS: Since 1987, 116 @entity0 over the age of 18 years with @entity9 (n = 104) or carinatum (n = 12) deformities underwent correction using a highly modified Ravitch repair, with a temporary internal support bar. The ages ranged from 19 to 53 years (mean 30.1). Eighty-six @entity0 sought repair after reviewing information regarding @entity1 available on the Internet. Each @entity0 experienced @entity8 with mild exertion and decreased endurance; 84 had @entity5 with activity; 75 had palpitations and/or @entity4 . Seven @entity0 underwent repair for symptomatic recurrent deformities. The mean severity score (chest width divided by distance from sternum to spine) was 4.8. The sternal bar was removed from 101 @entity0 6 months after the repair without complications. RESULTS: Each of the @entity0 with reduced endurance or @entity8 with mild exercise experienced marked improvement within 6 months. Chest discomfort was reduced in 82 of the 84 @entity0 . Complications included @entity7 (n = 7), pneumothorax (n = 2), @entity10 (n = 2), dislodged sternal bar (n = 3), and mildly @entity11 (n = 12). Mean hospitalization was 2.9 days; mean @entity3 was 122 mL. @entity2 was mild and of short duration (intravenous analgesics were used a mean of 2.1 days). There were no deaths. With a mean follow-up of 4.3 years, 109 of 113 respondents had a very good or excellent result. CONCLUSIONS: Although technically more difficult than in @entity0 , @entity1 may be repaired in adults with low morbidity, short hospital stay, and very good physiologic and cosmetic results.

title: Repair of @entity9 and XXXX in 116 adults.

answer: @entity1


abstract: OBJECTIVE: To determine the feasibility of surgically correcting @entity9 and @entity1 in adult @entity0 . SUMMARY BACKGROUND DATA: Although pectus @entity6 are common, many @entity0 progress to adulthood without surgical repair and experience increasing symptoms. There are sparse published data regarding repair of @entity1 in adults. METHODS: Since 1987, 116 @entity0 over the age of 18 years with @entity9 (n = 104) or carinatum (n = 12) deformities underwent correction using a highly modified Ravitch repair, with a temporary internal support bar. The ages ranged from 19 to 53 years (mean 30.1). Eighty-six @entity0 sought repair after reviewing information regarding @entity1 available on the Internet. Each @entity0 experienced @entity8 with mild exertion and decreased endurance; 84 had @entity5 with activity; 75 had palpitations and/or @entity4 . Seven @entity0 underwent repair for symptomatic recurrent deformities. The mean severity score (chest width divided by distance from sternum to spine) was 4.8. The sternal bar was removed from 101 @entity0 6 months after the repair without complications. RESULTS: Each of the @entity0 with reduced endurance or @entity8 with mild exercise experienced marked improvement within 6 months. Chest discomfort was reduced in 82 of the 84 @entity0 . Complications included @entity7 (n = 7), pneumothorax (n = 2), @entity10 (n = 2), dislodged sternal bar (n = 3), and mildly @entity11 (n = 12). Mean hospitalization was 2.9 days; mean @entity3 was 122 mL. @entity2 was mild and of short duration (intravenous analgesics were used a mean of 2.1 days). There were no deaths. With a mean follow-up of 4.3 years, 109 of 113 respondents had a very good or excellent result. CONCLUSIONS: Although technically more difficult than in @entity0 , @entity1 may be repaired in adults with low morbidity, short hospital stay, and very good physiologic and cosmetic results.

title: Repair of XXXX and @entity1 in 116 adults.

answer: @entity9


abstract: There is a strong need for antipruritic substances for treating itch in clinical dermatology. In one recent @entity0 study, topically applied @entity4 has been described to rapidly decrease @entity3 -induced itch. We have established a model for periferally elicited @entity2 by injecting @entity5 into the rostral back area (neck) in @entity1 . Using this model, we aimed to investigate the antipruritic potential of four different salicylic compounds, which all possess different skin penetration characteristics. Eighteen @entity1 were studied for 6 weeks. Prior to @entity5 injections (2 mg/ml, 50 micro l), 10 micro l of test substances was applied to a circular area 18 mm in diameter. The four substances were @entity6 , @entity9 , @entity10 and @entity7 , all solubilized in @entity8 to a concentration of 5% w/w. @entity10 and @entity7 were previously shown to be slowly absorbed through @entity1 skin in contrast to @entity6 and @entity9 . After @entity5 injections, scratching was monitored by video recording for 1.5 h. Compared with the vehicle, a lower number of scratch sequences were seen when @entity10 (P < 0.001) and @entity7 (P = 0.005) had been applied. The numbers of scratch sequences were lower with @entity10 and @entity7 than with the vehicle throughout the 1.5-h study period. We conclude that topical application of @entity10 and @entity7 could suppress @entity5 -induced scratching in rats. The antipruritic effect seems to be related to the slow drug release of the two substances. The results may be clinically relevant as @entity5 induces itch in @entity0 .

title: The effect of topically applied salicylic compounds on XXXX -induced scratching behaviour in hairless @entity1 .

answer: @entity5


abstract: There is a strong need for antipruritic substances for treating itch in clinical dermatology. In one recent @entity0 study, topically applied @entity4 has been described to rapidly decrease @entity3 -induced itch. We have established a model for periferally elicited @entity2 by injecting @entity5 into the rostral back area (neck) in @entity1 . Using this model, we aimed to investigate the antipruritic potential of four different salicylic compounds, which all possess different skin penetration characteristics. Eighteen @entity1 were studied for 6 weeks. Prior to @entity5 injections (2 mg/ml, 50 micro l), 10 micro l of test substances was applied to a circular area 18 mm in diameter. The four substances were @entity6 , @entity9 , @entity10 and @entity7 , all solubilized in @entity8 to a concentration of 5% w/w. @entity10 and @entity7 were previously shown to be slowly absorbed through @entity1 skin in contrast to @entity6 and @entity9 . After @entity5 injections, scratching was monitored by video recording for 1.5 h. Compared with the vehicle, a lower number of scratch sequences were seen when @entity10 (P < 0.001) and @entity7 (P = 0.005) had been applied. The numbers of scratch sequences were lower with @entity10 and @entity7 than with the vehicle throughout the 1.5-h study period. We conclude that topical application of @entity10 and @entity7 could suppress @entity5 -induced scratching in rats. The antipruritic effect seems to be related to the slow drug release of the two substances. The results may be clinically relevant as @entity5 induces itch in @entity0 .

title: The effect of topically applied salicylic compounds on @entity5 -induced scratching behaviour in hairless XXXX .

answer: @entity1


abstract: INTRODUCTION: Numerous reports on the inducibility of @entity4 ( @entity4 ) in @entity0 with atypical @entity1 and right precordial ST-elevation ( @entity5 ) are based on multicentre studies that have used different stimulation protocols. Therefore, we prospectively investigated the inducibility of @entity4 in these @entity0 using a uniform protocol. METHODS: In 41 consecutive @entity0 (29 males) showing a pattern of @entity1 and ST-elevation, programmed ventricular stimulation was performed in the right ventricular apex with up to three premature stimuli at sinus rhythm and at four different paced cycle lengths (500, 430, 370, and 330 ms) until refractoriness was reached or reproducible induction of a sustained (>30s) @entity4 occurred. If a @entity4 was not reproducibly inducible, the same protocol was repeated in the right ventricular outflow tract. RESULTS: A history of life-threatening events defined as @entity2 (n=17) or aborted @entity3 (n=13) was present in 30 @entity0 (73%); 11 individuals were asymptomatic. Inducibility (68%) was similar between symptomatic (n=21, 70%) and asymptomatic @entity0 (n=7, 64%). In 16 (39%) @entity0 , @entity4 were reproducibly inducible. If @entity0 were only stimulated in the right ventricular apex, inducibility rate decreased to 39%. If only two @entity6 at two sites were used it was as low as 32%. The mean coupling intervals of the second and third premature stimuli inducing sustained @entity4 were short: 189+/-21 ms vs 186+/-22 ms, respectively. Forty-four percent of all @entity0 (i.e. 64% of the inducible @entity0 ) had inducible @entity4 only with coupling intervals shorter than 200 ms. CONCLUSIONS: The stimulation protocol markedly influences the extent of inducibility of @entity4 in @entity0 with @entity1 and ST-segment elevation. These findings question the significance of previous multicentre studies using different stimulation protocols and should have implications for further studies.

title: Electrophysiologic investigation in @entity5 ; yield of programmed ventricular stimulation at two ventricular sites with up to three XXXX .

answer: @entity6


abstract: INTRODUCTION: Numerous reports on the inducibility of @entity4 ( @entity4 ) in @entity0 with atypical @entity1 and right precordial ST-elevation ( @entity5 ) are based on multicentre studies that have used different stimulation protocols. Therefore, we prospectively investigated the inducibility of @entity4 in these @entity0 using a uniform protocol. METHODS: In 41 consecutive @entity0 (29 males) showing a pattern of @entity1 and ST-elevation, programmed ventricular stimulation was performed in the right ventricular apex with up to three premature stimuli at sinus rhythm and at four different paced cycle lengths (500, 430, 370, and 330 ms) until refractoriness was reached or reproducible induction of a sustained (>30s) @entity4 occurred. If a @entity4 was not reproducibly inducible, the same protocol was repeated in the right ventricular outflow tract. RESULTS: A history of life-threatening events defined as @entity2 (n=17) or aborted @entity3 (n=13) was present in 30 @entity0 (73%); 11 individuals were asymptomatic. Inducibility (68%) was similar between symptomatic (n=21, 70%) and asymptomatic @entity0 (n=7, 64%). In 16 (39%) @entity0 , @entity4 were reproducibly inducible. If @entity0 were only stimulated in the right ventricular apex, inducibility rate decreased to 39%. If only two @entity6 at two sites were used it was as low as 32%. The mean coupling intervals of the second and third premature stimuli inducing sustained @entity4 were short: 189+/-21 ms vs 186+/-22 ms, respectively. Forty-four percent of all @entity0 (i.e. 64% of the inducible @entity0 ) had inducible @entity4 only with coupling intervals shorter than 200 ms. CONCLUSIONS: The stimulation protocol markedly influences the extent of inducibility of @entity4 in @entity0 with @entity1 and ST-segment elevation. These findings question the significance of previous multicentre studies using different stimulation protocols and should have implications for further studies.

title: Electrophysiologic investigation in XXXX ; yield of programmed ventricular stimulation at two ventricular sites with up to three @entity6 .

answer: @entity5


abstract: OBJECTIVE: To investigate the mechanism of @entity3 resistance in @entity6 . METHODS: WHONET-5 software was used to analyze the trend of @entity5 resistance in @entity6 collected from 1999 to 2001 at Peking Union Medical College Hospital. Analytical isoelectric focusing was used to measure the pI of the beta-lactamase. Conjugation experiment was used to study the transfer of @entity5 resistance and plasmid DNA was extracted and purified with Qiagen Plasmid Mini Kit. The homology of the isolates was determined by pulsed field gel electrophoresis (PFGE). Integrase genes and blaIMP-, blaVIM-, blaOXA- genes for resistant isolates were amplified and sequenced. RESULTS: @entity4 resistance in A. baumannii was ranged from 1.8%-8.5%, but only 9 resistant isolates were viable. They were co-resistant to other @entity3 , @entity8 , @entity9 , and @entity1 , and four isolates were resistant to @entity2 . Impipenem resistance could not be transferred to susceptible strains. No plasmid was extracted. Each isolate produced TEM-1, AmpC, and two enzymes (pI 6.7, 6.0), which can not be inhibited by @entity7 and @entity0 . Each isolate had class I intergase gene. Nine isolates were all negative for PCR of blaIMP- and blaVIM- genes, but positive for blaOXA-23 specific PCR. Sequencing found 100% homology with blaOXA-23. PFGE found 3 clones (A type: 5 isolates; B type: 3 isolates; C type: 1 isolate). Control isolates ( @entity4 -susceptible, but @entity8 , @entity2 , and @entity1 resistant) were also A clone. CONCLUSIONS: Production of OXA-23 carbapenemase in A. baumannii was one of the main mechanisms of @entity3 resistance at our hospital. It brings concern that @entity4 -resistant clone has evoluted from nosocomial multiple-resistant strains.

title: [Mechanism of @entity3 resistance in XXXX ].

answer: @entity6


abstract: OBJECTIVE: To investigate the mechanism of @entity3 resistance in @entity6 . METHODS: WHONET-5 software was used to analyze the trend of @entity5 resistance in @entity6 collected from 1999 to 2001 at Peking Union Medical College Hospital. Analytical isoelectric focusing was used to measure the pI of the beta-lactamase. Conjugation experiment was used to study the transfer of @entity5 resistance and plasmid DNA was extracted and purified with Qiagen Plasmid Mini Kit. The homology of the isolates was determined by pulsed field gel electrophoresis (PFGE). Integrase genes and blaIMP-, blaVIM-, blaOXA- genes for resistant isolates were amplified and sequenced. RESULTS: @entity4 resistance in A. baumannii was ranged from 1.8%-8.5%, but only 9 resistant isolates were viable. They were co-resistant to other @entity3 , @entity8 , @entity9 , and @entity1 , and four isolates were resistant to @entity2 . Impipenem resistance could not be transferred to susceptible strains. No plasmid was extracted. Each isolate produced TEM-1, AmpC, and two enzymes (pI 6.7, 6.0), which can not be inhibited by @entity7 and @entity0 . Each isolate had class I intergase gene. Nine isolates were all negative for PCR of blaIMP- and blaVIM- genes, but positive for blaOXA-23 specific PCR. Sequencing found 100% homology with blaOXA-23. PFGE found 3 clones (A type: 5 isolates; B type: 3 isolates; C type: 1 isolate). Control isolates ( @entity4 -susceptible, but @entity8 , @entity2 , and @entity1 resistant) were also A clone. CONCLUSIONS: Production of OXA-23 carbapenemase in A. baumannii was one of the main mechanisms of @entity3 resistance at our hospital. It brings concern that @entity4 -resistant clone has evoluted from nosocomial multiple-resistant strains.

title: [Mechanism of XXXX resistance in @entity6 ].

answer: @entity3


abstract: OBJECTIVE: To investigate perioperative patterns of @entity3 and @entity1 secretion rhyme in @entity0 undergoing coronary artery bypass grafting surgery. METHODS: Eleven male @entity0 scheduled for elective coronary artery bypass grafting surgery (CABG) under hypothermic cardiopulmonary bypass (CPB) were enrolled in the study. Anesthesia was induced and maintained with @entity2 (3 mg.kg-1.h-1) and supplemented with @entity4 (15 micrograms/kg). Blood samples were taken during surgery at specific time-points and every 3 h in the immediate postoperative period and postoperative day 2 and day 3. Plasma @entity3 and @entity1 levels were measured by radioimmunoassay and enzyme-linked immunosorbent assay respectively. RESULTS: During surgery, plasma @entity3 levels were below the minimum sensitivity level but low levels, without circadian variation, were measured during the immediate postoperative period. During postoperative day 2 and day 3, circadian secretion patterns of @entity3 were present in 10 @entity0 and showed an inverse correlation with light intensity exposed (r = -0.480, P = 0.01). Plasma @entity1 levels in the immediate postoperative period were significantly higher than those before induction of anesthesia (P < 0.01). During postoperative day 2 and day 3, only 3 @entity0 regained circadian secretion of @entity1 . CONCLUSIONS: It is concluded that @entity3 and @entity1 secretion are disrupted during cardiac surgery and in the immediate postoperative period.

title: [Perioperative XXXX secretion rhyme in @entity0 undergoing coronary artery bypass grafting surgery].

answer: @entity3


abstract: OBJECTIVE: To investigate perioperative patterns of @entity3 and @entity1 secretion rhyme in @entity0 undergoing coronary artery bypass grafting surgery. METHODS: Eleven male @entity0 scheduled for elective coronary artery bypass grafting surgery (CABG) under hypothermic cardiopulmonary bypass (CPB) were enrolled in the study. Anesthesia was induced and maintained with @entity2 (3 mg.kg-1.h-1) and supplemented with @entity4 (15 micrograms/kg). Blood samples were taken during surgery at specific time-points and every 3 h in the immediate postoperative period and postoperative day 2 and day 3. Plasma @entity3 and @entity1 levels were measured by radioimmunoassay and enzyme-linked immunosorbent assay respectively. RESULTS: During surgery, plasma @entity3 levels were below the minimum sensitivity level but low levels, without circadian variation, were measured during the immediate postoperative period. During postoperative day 2 and day 3, circadian secretion patterns of @entity3 were present in 10 @entity0 and showed an inverse correlation with light intensity exposed (r = -0.480, P = 0.01). Plasma @entity1 levels in the immediate postoperative period were significantly higher than those before induction of anesthesia (P < 0.01). During postoperative day 2 and day 3, only 3 @entity0 regained circadian secretion of @entity1 . CONCLUSIONS: It is concluded that @entity3 and @entity1 secretion are disrupted during cardiac surgery and in the immediate postoperative period.

title: [Perioperative @entity3 secretion rhyme in XXXX undergoing coronary artery bypass grafting surgery].

answer: @entity0


abstract: We report a case of @entity2 infiltrating the left main bronchus in which radical esophagectomy with clear surgical margins could be performed after preoperative radiochemotherapy. The @entity0 was a 57-year-old @entity0 , who was found to have @entity5 of the middle thoracic esophagus during a work-up of @entity4 . Bronchoscopy revealed an elevated region protruding into the lumen of the left main bronchus. After radiochemotherapy (liniac irradiation + low-dose FP therapy), the esophageal and @entity6 became smaller. The case was evaluated as a clinically complete response. Bronchoscopic ultrasonography showed a clear boundary between the membranous portion of the @entity3 and the esophageal wall. Based on these findings, the lesion was considered resectable and radical surgery, including 3-field lymph node dissection, was performed. The resected esophageal specimen had @entity1 covered with normal mucosa. However, the @entity0 is currently healthy with no evidence of disease. The indication for surgical resection in cases of @entity2 with contiguous spread, and a good response to preoperative radiochemotherapy, is controversial. It is necessary to verify the effectiveness of surgical resection, as a secondary treatment, by accumulating data on cases such as the present one.

title: [Resection of XXXX infiltrating the left main bronchus following complete response to preoperative radiochemotherapy--a case report].

answer: @entity2


abstract: OBJECTIVE: To investigate the antigenicity of the peptide vaccine HDS from @entity2 glucosyltransferase and its ability to induce protective immune responses in an experimental @entity0 model of @entity1 . METHODS: Artificial antigen HDS-KLH, peptide HDS, glycosyltransferase were injected to immunize @entity0 . Measurement of the specific anti-HDS, GTF IgG or IgA concentration in saliva and serum were undertaken by ELISA among the experimental groups. Gnotobiotic @entity0 model was developed when challenged @entity2 and a caries promoting diet. The jaws of the @entity0 were selected and dyed. The Keyes caries score for each jaw were counted. RESULTS: The level of serum and salivary specific anti-HDS IgG and IgA in the group immunized by HDS-KLH was significantly higher than that in control group (P < 0.05). The Keyes caries score of GTF, HDS and HDS-KLH immunized group were significantly lower than that of control group, especially lower in smooth tooth surface. CONCLUSION: Artificial antigen HDS-KLH could induce immune response. As a peptide vaccine, HDS-KLH could reduce the caries incidence in experimental @entity0 model.

title: [The study of peptide vaccine HDS from XXXX glucosyltransferase].

answer: @entity2


abstract: OBJECTIVE: To study @entity2 mortality among main subgroups of workers employed in VC/ @entity10 production potentially exposed to toxics and carcinogens. MATERIALS AND METHODS: We reanalyzed the mortality of 1,658 males (follow up 1972-1995; 35,626 @entity0 years; 170 @entity5 ) by Poisson regression, adjusting for age, age at hiring, calendar period, length of exposure and latency. We calculated the relative risks (RR) and the 95% confidence intervals (CI) for @entity10 baggers (n. = 197), @entity10 compound (n. = 403) and autoclave (n. = 209) workers. As an internal reference we used two groups of workers: technicians and employees (main reference: n. = 202 subjects), with the group of other blue collar workers (n. = 639) added for statistical purposes only (minor reference: n. = 841 subjects). RESULTS: Pooling the four subgroups of exposed workers, the comparison with the main reference group allowed us to detect increased mortality from all causes of @entity5 (RR = 2.09; CI = 1.09-4.00; 160 @entity5 ), all @entity2 (RR = 1.53; ns; 81 @entity5 ), @entity1 (RR = 2.05; ns; 29 @entity5 ) and @entity3 (RR = 3.57; ns; 29 @entity5 ). The analysis for each specific subgroup revealed increased mortality from all causes of @entity5 among both @entity10 baggers (RR = 2.66; CI = 1.27-5.59) and @entity10 compound workers (RR = 2.68; CI = 1.36-5.27). Comparison of the minor reference group with the overall population of exposed workers showed increased RRs for other diseases, namely, @entity4 (RR = 4.08; ns; 9 @entity5 ), @entity6 and @entity9 (RR = 2.97; ns; 7 @entity5 ) and @entity8 (RR = 3.30; ns; 11 @entity5 ). The analysis for each specific subgroup revealed significantly increased RR for all @entity2 among @entity10 compound workers (RR = 1.74; CI = 1.06-2.85), for @entity1 among @entity10 baggers workers (RR = 3.04; CI = 1.15-7.99) and for @entity4 (RR = 9.57; CI = 1.69-54.1) and @entity8 (RR = 6.32; CI = 1.37-29.07) among autoclave workers. In addition, the two @entity5 from @entity7 were observed among @entity10 compound workers. CONCLUSIONS: To highlight the risk previously reported in the literature and to reduce the possible dilution effect (due to comparison bias, healthy worker effect), it proved methodologically pivotal to separate exposed and probably unexposed workers (considered as an internal reference group).

title: [Reanalysis of mortality in a petrochemical plant producing vinyl chloride and XXXX ].

answer: @entity10


abstract: PURPOSE: To investigate the relationship between the susceptibility of @entity2 ( @entity2 ) cells to DNA damage-induced apoptosis, the kinetics of DNA strand-break rejoining, and chromosome damage after exposure to ionizing irradiation. MATERIALS AND METHODS: Lymphocytes from @entity2 @entity0 were gamma-irradiated in vitro with 0.2-5 Gy and stimulated by @entity1 cowan I (SAC I) for estimation of chromosomal damage. Induction of apoptosis after irradiation was studied in 50 @entity0 by two methods: morphological characterization of apoptotic cells after fluorescent staining (Hoechst), and specific quantification of mono- and oligonucleosomes in cytoplasmic cell fractions (ELISA assay). Morphological chromosome damage was scored in the first cell generation after irradiation (13 @entity0 ). In parallel, the kinetics of DNA single-strand break rejoining were investigated by the alkaline comet assay (12 @entity0 ). RESULTS: Ionizing irradiation did not induce apoptosis in lymphocytes from a subset of @entity2 @entity0 . The results suggest that @entity2 cells resistant to radiation-induced apoptosis could repair DNA strand-breaks more rapidly and showed a higher level of chromosome aberrations than radiation-sensitive @entity2 cells. CONCLUSION: Each of three biological effects observed (apoptosis, kinetics of DNA single-strand-break repair, chromosomal damage) might be explained by different modifications occurring in irradiated @entity2 cells. Their convergence strongly suggests that resistance to apoptotic death initiation by DNA damage may be impeded by a rapid engaging of the DNA repair mechanisms. The higher level of chromosome aberrations observed in these cells suggests that the type of DNA repair system involved may generate inaccurate repair.

title: High levels of chromosome aberrations correlate with impaired in vitro radiation-induced apoptosis and DNA repair in XXXX B-chronic lymphocytic leukaemia cells.

answer: @entity0


abstract: In the early days of video-assisted laparoscopic cholecystectomy (VLC), @entity1 was considered a contraindication for the procedure. We reviewed charts from 304 @entity0 undergoing VLC; 90 @entity0 were @entity1 , and among these, according to a classification currently used by medical nutritionists and based on BMI, 45 were overweight (BMI > or = 25 < or = 29.9), 27 were considered conventionally @entity1 (BMI > or = 30 and < 40) and 18 morbidly @entity1 (BMI > or = 40). In this study we considered only the morbidly @entity1 @entity0 (5 males and 13 females). The average age was 42.3 years (range: 21-65) and the average weight 275 Ib (range: 186-331 Ib). Six @entity0 had previously undergone abdominal surgery. All @entity0 were symptomatic for @entity7 , and 5 of them were suffering from acute @entity6 . Mean operative time was 20 minutes (range: 10-45 minutes) longer than that of @entity1 @entity0 . No open conversion was necessary. No major postoperative morbidity and no cases of mortality occurred. The mean hospital stay and resumption of normal diet were similar to those of @entity1 @entity0 . Regardless of the higher postoperative risks after open cholecystectomy in @entity1 @entity0 ( @entity4 , @entity5 , wound @entity3 and @entity2 ), we suggest VLC as the procedure of choice for cholecystectomy in these @entity0 .

title: Laparoscopic cholecystectomy in the morbidly XXXX .

answer: @entity1


abstract: @entity2 ( @entity2 ) is believed to play an important role in cardiac ischaemia/reperfusion injury. @entity2 is synthesized from preproET-1 by the action of @entity3 ( @entity3 ). It is unclear to what extent the ET system is activated following prolonged ischaemia. In this study we used a model mimicking the conditions of the donor heart during transplantation. Isolated @entity0 hearts perfused with Krebs-Henseleit buffer were subjected to 30 min of normothermic perfusion, then 4 h of @entity1 at 4 degrees C with St Thomas' Hospital solution, followed by reperfusion for 2 h. Hearts were freeze-clamped at different time points during the protocol. Using quantitative reverse transcription-PCR, relative levels of @entity5 mRNA expression were measured and compared with a housekeeping gene ( @entity4 ). During reperfusion there was a consistent decrease in coronary flow to approx. 85-90% of pre-ischaemic flow. There was no significant alteration in preproET-1 mRNA expression during 2 h of reperfusion. However, @entity3 mRNA expression was increased by 77.5% at 1 h and by 74.6% at 2 h following ischaemia compared with pre-ischaemic values (P<0.05). Thus we conclude that @entity3 mRNA expression is increased following prolonged hypothermic @entity1 . Elevations in the expression of this enzyme may help to explain the role of the ET system in the pathogenesis of ischaemia/reperfusion injury following cardiac surgery and transplantation.

title: Up-regulation of endothelin-converting-enzyme mRNA expression following XXXX .

answer: @entity1


abstract: The @entity4 binding proteins (pebps) are an evolutionarily conserved family of proteins recently implicated in mitogen-activated protein (MAP) kinase pathway regulation, where they are called raf kinase inhibitory proteins. Here, we describe the cloning, cellular localization, and partial characterization of a new member, pebp-2, with potential roles in male fertility. Expression data show that pebp-2 is a testis-specific 21-kDa protein found within late meiotic and haploid germ cells in a stage-specific pattern that is temporally distinct from that of @entity3 . Sequence analyses suggest that pebp-2 forms a distinct subset of the pebp family within mammals. Database analyses revealed the existence of a third subset. Analysis suggests that the specificity/regulation of the distinct pebps subsets is likely to be determined by the @entity1 terminal 40 @entity2 or the 3' untranslated region, where the majority of sequence differences occur. Protein homology modeling suggests that pebp-2 protein is, however, topologically similar to other pebps and composed of Greek key fold motifs, a dominant beta-sheet formed from five anti-parallel beta strands forming a shallow groove associated with a putative @entity4 binding site. The pebp-2 gene is intronless and data suggest that it is a retrogene derived from @entity3 . Further, pebp-2 colocalizes with members of the MAP kinase pathway in late spermatocytes and spermatids and on the midpiece of epididymal sperm. These data raise the possibility that pebp-2 is a novel @entity0 in the MAP kinase signaling pathway, with a role in spermatogenesis or posttesticular sperm maturation.

title: Identification of a novel testis-specific member of the XXXX binding protein family, pebp-2.

answer: @entity4


abstract: BACKGROUND: Following the emergence of @entity1 and @entity5 resistant @entity3 in the United States, inclusion of @entity2 in empiric therapy for all suspected @entity4 was recommended by the American Academy of Pediatrics. Few data are available to evaluate this policy. AIMS: To examine the management and clinical course in relation to antibiotic therapy of a large unselected cohort of @entity0 with @entity3 in a geographic area where antibiotic resistance has recently increased. METHODS: Retrospective review of all cases of @entity3 in a defined population (Sydney, Australia), 1994-99. RESULTS: A total of 104 cases without predisposing illnesses were identified; timing of lumbar puncture (LP) was known in 103. Resistance to @entity1 increased from 0 to 20% over the study period. Only 57 (55%) had an early LP (prior to parenteral antibiotics); 55 (96%) had organisms on Gram stain. Severe disease (intensive care admission or death) increased significantly from 57 cases with early LP (28%) to 33 with delayed LP (42%) to 13 with no LP (62%). Evidence of @entity6 was available within 24 hours in 85% of those with delayed or no LP. Outcome was not related to empiric @entity2 use, which increased from 5% prior to 1998 to 48% in 1999. CONCLUSION: LP is frequently delayed in @entity3 . Based on disease severity, empiric @entity2 is most justified when LP is deferred. If an early LP is done, @entity2 can be withheld if Gram positive diplococci are not seen.

title: The emergence of resistant XXXX --implications for empiric therapy.

answer: @entity3