abstract: BACKGROUND: Robot-assisted laparoscopic radical prostatectomy (RALP) has become widely used without high-grade evidence of superiority regarding long-term clinical outcomes compared with open retropubic radical prostatectomy (RRP), the gold standard. OBJECTIVE: To compare @entity0 -reported @entity2 and @entity3 12 mo after RALP or RRP. DESIGN, SETTING, AND @entity0 : This was a prospective, controlled, nonrandomised trial of @entity0 undergoing prostatectomy in 14 centres using RALP or RRP. Clinical-record forms and validated @entity0 questionnaires at baseline and 12 mo after surgery were collected. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSES: Odds ratios (ORs) were calculated with logistic regression and adjusted for possible confounders. The primary end point was @entity2 (change of pad less than once in 24h vs one time or more per 24h) at 12 mo. Secondary end points were @entity3 at 12 mo and positive surgical margins. RESULTS AND LIMITATIONS: Of 2625 eligible @entity0 , 2431 (93%) could be evaluated for the primary end point. At 12 mo after RALP, 366 @entity0 (21.3%) were incontinent, as were 144 (20.2%) after RRP. The adjusted OR was 1.08 (95% confidence interval [CI], 0.87-1.34). @entity3 was observed in 1200 @entity0 (70.4%) 12 mo after RALP and 531 (74.7%) after RRP. The adjusted OR was 0.81 (95% CI, 0.66-0.98). The frequency of positive surgical margins did not differ significantly between groups: 21.8% in the RALP group and 20.9% in the RRP group (adjusted OR: 1.09; 95% CI, 0.87-1.35). The nonrandomised design is a limitation. CONCLUSIONS: In a Swedish setting, RALP for @entity1 was modestly beneficial in preserving erectile function compared with RRP, without a statistically significant difference regarding @entity2 or surgical margins. @entity0 SUMMARY: We compared @entity0 -reported @entity2 after prostatectomy with two types of surgical technique. There was no statistically significant improvement in the rate of urinary leakage, but there was a small improvement regarding erectile function after robot-assisted operation.

title: Urinary Incontinence and XXXX After Robotic Versus Open Radical Prostatectomy: A Prospective, Controlled, Nonrandomised Trial.

answer: @entity3


abstract: Neospora caninum-induced abortion is a major production problem in the dairy @entity1 industry in the United States and worldwide. Abortions attributable to naturally acquired N @entity0 also have been observed in pygmy @entity2 . We studied experimentally induced @entity0 with N caninum in pregnant pygmy does to determine whether abortions attributable to N @entity0 would occur after inoculation. Seven pregnant pygmy does (1 control doe and 6 inoculated with N caninum) were studied. The control doe remained clinically normal throughout the study and delivered 2 healthy kids. Abortion, @entity3 , and stillbirths were observed in some pregnant does inoculated with N caninum. Two pregnant pygmy does inoculated with N caninum early in gestation (day 51) had fetuses that died and were aborted, or died and were reabsorbed. Neospora caninum tachyzoites and lesions were observed in the brain, spinal cord, and heart of aborted fetuses; parasites also were isolated from the placenta. Four additional pregnant pygmy does (2 inoculated at mid-gestation [day 85], and 2 at late gestation [day 127]) did not abort after inoculation. However, 1 doe inoculated during mid-gestation delivered a stillborn fetus that had died about 1 week prior to parturition. This kid was congenitally infected with N caninum. Neospora caninum was isolated from the placentas of all inoculated does examined. Neonatal neosporosis was not observed in live-born kids, nor were stages of N caninum isolated from any live-born kid. Does did not undergo abortion or have congenitally infected kids when they were rebred and evaluated for neosporosis.

title: Abortions, XXXX , and stillbirths in pregnant pygmy @entity2 inoculated with tachyzoites of Neospora caninum.

answer: @entity3


abstract: Neospora caninum-induced abortion is a major production problem in the dairy @entity1 industry in the United States and worldwide. Abortions attributable to naturally acquired N @entity0 also have been observed in pygmy @entity2 . We studied experimentally induced @entity0 with N caninum in pregnant pygmy does to determine whether abortions attributable to N @entity0 would occur after inoculation. Seven pregnant pygmy does (1 control doe and 6 inoculated with N caninum) were studied. The control doe remained clinically normal throughout the study and delivered 2 healthy kids. Abortion, @entity3 , and stillbirths were observed in some pregnant does inoculated with N caninum. Two pregnant pygmy does inoculated with N caninum early in gestation (day 51) had fetuses that died and were aborted, or died and were reabsorbed. Neospora caninum tachyzoites and lesions were observed in the brain, spinal cord, and heart of aborted fetuses; parasites also were isolated from the placenta. Four additional pregnant pygmy does (2 inoculated at mid-gestation [day 85], and 2 at late gestation [day 127]) did not abort after inoculation. However, 1 doe inoculated during mid-gestation delivered a stillborn fetus that had died about 1 week prior to parturition. This kid was congenitally infected with N caninum. Neospora caninum was isolated from the placentas of all inoculated does examined. Neonatal neosporosis was not observed in live-born kids, nor were stages of N caninum isolated from any live-born kid. Does did not undergo abortion or have congenitally infected kids when they were rebred and evaluated for neosporosis.

title: Abortions, @entity3 , and stillbirths in pregnant pygmy XXXX inoculated with tachyzoites of Neospora caninum.

answer: @entity2


abstract: BACKGROUND: Although the safety of same day discharge (SDD) after laparoscopic cholecystectomy (LC) for symptomatic @entity2 (SC) and @entity1 ( @entity1 ) in adults has been well documented in the literature, the same data in the pediatric population are lacking. We have recently instituted a protocol for SDD after LC for SC and @entity1 , and this study is an analysis of our initial experience. METHODS: A retrospective chart review of all @entity0 who underwent LC for @entity1 and SC in our institution from January 2011-July 2014 was performed. RESULTS: A total of 227 LC were performed for SC and @entity1 during the study period. Approximately 25% (n  =  57) of @entity0 were in the SDD group. The remaining 75% (n  =  170) of @entity0 were admitted at least overnight stay (ONS) for the following reasons: medical 16.5% (n  =  28), surgery ending too late 4.1% (n  =  7), or clinical care habits 79.4% (n  =  135). Comparing the SDD group with ONS group, no differences were found in the complication rate, readmissions, or follow up before scheduled appointment. Length of stay was significantly less for the SDD group than for the ONS. A trend for more SDDs was observed as time elapsed from initiation of the protocol. Also, earlier completion of surgery trended toward SDD. CONCLUSIONS: SDD appears safe for pediatric @entity0 undergoing LC for @entity1 or SC. The main obstacles to discharge were time of surgery completion and clinical care habits, both of which improved as comfort level with SDD grew among the staff.

title: Same day discharge after laparoscopic cholecystectomy in XXXX .

answer: @entity0


abstract: BACKGROUND: Although only a few @entity4 ( @entity4 ) @entity0 develop frank @entity3 ( @entity3 ), motor @entity2 (MNDys) occur in a larger proportion of @entity0 . The aim of this study is to evaluate MNDys and @entity3 in a sample of consecutively enrolled sporadic @entity4 @entity0 . METHODS: Clinical and neurophysiological evaluations (i.e. needle electromyography) assessed lower (LMN) and upper (UMN) motor neuron function at the baseline in 70 probable @entity4 @entity0 (i.e., 26 behavioural variant-bvFTD, 20 primary progressive aphasias-PPAs and 24 corticobasal syndrome-CBS). To obtain a more accurate estimation, quantitative scales were also applied (i.e. ALSFRS-r and UMN scale). @entity0 were screened for @entity6 , @entity7 and @entity5 mutations. A mean clinical follow-up of 27.8  22.4 months assessed MNDys progression and the clinical presentation of @entity3 . RESULTS: Five genetic cases were identified. Within the sample of sporadic @entity0 , a relative low rate of @entity4 @entity0 was diagnosed as probable @entity3 (5%), while a higher proportion of @entity0 (17%) showed clinical and neurophysiological MNDys. Thirteen @entity0 (20%) presented with isolated clinical signs of @entity1 , and 8 @entity0 (12%) showed neurogenic changes at the electromyography. No differences in @entity4 phenotype and disease duration were found between MNDys positive and negative @entity0 . Clinical MNDys were highly associated with positive electromyographic findings. At follow-up, no MNDys positive @entity0 developed @entity3 . CONCLUSION: Neurophysiological and clinical examinations revealed mild MNDys in @entity4 @entity0 not fulfilling criteria for @entity3 . This condition did not evolve at a mean follow-up of two years. These results, indicating a @entity2 and lower motor neurons, suggest that @entity4 @entity0 may be more at risk of MNDys than the general population.

title: Motor @entity2 in the XXXX spectrum: A clinical and neurophysiological study.

answer: @entity4


abstract: BACKGROUND: Although only a few @entity4 ( @entity4 ) @entity0 develop frank @entity3 ( @entity3 ), motor @entity2 (MNDys) occur in a larger proportion of @entity0 . The aim of this study is to evaluate MNDys and @entity3 in a sample of consecutively enrolled sporadic @entity4 @entity0 . METHODS: Clinical and neurophysiological evaluations (i.e. needle electromyography) assessed lower (LMN) and upper (UMN) motor neuron function at the baseline in 70 probable @entity4 @entity0 (i.e., 26 behavioural variant-bvFTD, 20 primary progressive aphasias-PPAs and 24 corticobasal syndrome-CBS). To obtain a more accurate estimation, quantitative scales were also applied (i.e. ALSFRS-r and UMN scale). @entity0 were screened for @entity6 , @entity7 and @entity5 mutations. A mean clinical follow-up of 27.8  22.4 months assessed MNDys progression and the clinical presentation of @entity3 . RESULTS: Five genetic cases were identified. Within the sample of sporadic @entity0 , a relative low rate of @entity4 @entity0 was diagnosed as probable @entity3 (5%), while a higher proportion of @entity0 (17%) showed clinical and neurophysiological MNDys. Thirteen @entity0 (20%) presented with isolated clinical signs of @entity1 , and 8 @entity0 (12%) showed neurogenic changes at the electromyography. No differences in @entity4 phenotype and disease duration were found between MNDys positive and negative @entity0 . Clinical MNDys were highly associated with positive electromyographic findings. At follow-up, no MNDys positive @entity0 developed @entity3 . CONCLUSION: Neurophysiological and clinical examinations revealed mild MNDys in @entity4 @entity0 not fulfilling criteria for @entity3 . This condition did not evolve at a mean follow-up of two years. These results, indicating a @entity2 and lower motor neurons, suggest that @entity4 @entity0 may be more at risk of MNDys than the general population.

title: Motor XXXX in the @entity4 spectrum: A clinical and neurophysiological study.

answer: @entity2


abstract: OBJECTIVE: Our study investigated the role of @entity5 and its molecular @entity1 ( @entity1 ) cells. METHODS: An inhibitor of @entity5 was transiently transfected into the @entity1 cell line, MHCC-97L. The effect of this transfection on mRNA levels of epithelial-mesenchymal transition (EMT)-related genes was measured by fluorescence-based quantitative real-time polymerase chain reaction (qRT-PCR). Further, protein levels of EMT-related genes, cell proliferation and apoptosis-related markers were assessed by Western blot analysis in these transfected cells. @entity0 and wound-healing assay were used to evaluate the proliferation and migration of MHCC-97L cells in presence and in absence of @entity5 inhibitor. RESULTS: Compared with miR-NC control group, qRT-PCR results in anti- @entity5 group revealed a significant reduction in the mRNA levels of @entity4 , with a concomitant increasing in @entity3 mRNA level (all P < 0.05). Western blot results showed higher @entity4 and @entity2 protein expressions in anti- @entity5 group compared to miR-NC group (P < 0.05). In addition, @entity3 and Ki-67 protein expression was found sharply decreased in anti- @entity5 group compared to miR-NC group (P < 0.05). Consistent with this, wound-healing and @entity0 assay showed that migration and proliferation capacity of MHCC-97L cells in anti- @entity5 group is significantly increased compared with miR-NC group (both P < 0.05). CONCLUSION: Our study reveals an important role of @entity5 in inhibiting EMT, proliferation and migration in @entity1 cells, suggesting the possibility of @entity5 -based therapeutics in @entity1 .

title: MicroRNA-200a inhibits epithelial-mesenchymal transition in human XXXX cell line.

answer: @entity1


abstract: BACKGROUND: @entity5 is correlated with @entity2 progression and @entity1 in types of @entity2 . But the role of @entity5 in @entity3 remains unclear. In this study, we aimed to investigate the expression of @entity5 and its correlation with clinical outcomes in @entity3 . @entity0 AND METHODS: Immunohistochemical staining was performed in samples from 288 @entity0 with @entity3 . We used Kaplan-Meier method and Cox proportional hazard models to value the association between @entity5 expression and clinical outcome. Nomogram was constructed to predict overall survival at 5 and 8 years after nephrectomy. RESULTS: @entity5 expression was significantly decreased in @entity2 compared to non- @entity2 tissue (P<0.001). Lower @entity5 expression in @entity2 predicted a shorter survival time (P=0.007). By multivariate cox analysis, @entity5 was defined as an independent prognostic factor (P=0.006). The nomogram performed better in predicting 5- and 8-year overall survival than the @entity4 stage alone in @entity3 . CONCLUSION: @entity5 is an independent prognostic factor for @entity3 and could be incorporated with the other parameters to predict 5- and 8-year overall survival for @entity3 @entity0 .

title: Decreased expression of mucin 18 is associated with unfavorable postoperative prognosis in @entity0 with XXXX .

answer: @entity3


abstract: BACKGROUND: @entity5 is correlated with @entity2 progression and @entity1 in types of @entity2 . But the role of @entity5 in @entity3 remains unclear. In this study, we aimed to investigate the expression of @entity5 and its correlation with clinical outcomes in @entity3 . @entity0 AND METHODS: Immunohistochemical staining was performed in samples from 288 @entity0 with @entity3 . We used Kaplan-Meier method and Cox proportional hazard models to value the association between @entity5 expression and clinical outcome. Nomogram was constructed to predict overall survival at 5 and 8 years after nephrectomy. RESULTS: @entity5 expression was significantly decreased in @entity2 compared to non- @entity2 tissue (P<0.001). Lower @entity5 expression in @entity2 predicted a shorter survival time (P=0.007). By multivariate cox analysis, @entity5 was defined as an independent prognostic factor (P=0.006). The nomogram performed better in predicting 5- and 8-year overall survival than the @entity4 stage alone in @entity3 . CONCLUSION: @entity5 is an independent prognostic factor for @entity3 and could be incorporated with the other parameters to predict 5- and 8-year overall survival for @entity3 @entity0 .

title: Decreased expression of mucin 18 is associated with unfavorable postoperative prognosis in XXXX with @entity3 .

answer: @entity0


abstract: UNASSIGNED: @entity6 ( @entity6 ) presents a significant health burden and is associated with high @entity2 and mortality. This is particularly true in African Americans who generally have higher rates of @entity2 . Outcomes in @entity6 are related to extent of @entity2 , but markers for outcome are not clearly established. @entity9 ( @entity9 ) has emerged as an important measure of left ventricular systolic function that is additive to traditional ejection fraction (EF). It can be measured on routine digital echocardiography and is reproducible. This study tested the hypothesis that @entity9 is associated with mortality in black Americans with @entity6 and preserved EF. Forty-eight outpatients undergoing hemodialysis, 59.4    13.3  years, with EF >= 50% were prospectively enrolled. @entity9 , measured by an offline speckle tracking algorithm, ranged from  -8.6% to  -22.0% with a mean of  -13.4%, substantially below normal (-16% or more negative). The prevalence of @entity8 , as determined by @entity9 , was 89%. @entity0 were followed for an average of 1.9  years; all-cause mortality was 19% (9 deaths). @entity9 was significantly associated with mortality (hazard ratio 1.15, 95% confidence interval 1.02 to 1.30, p  = 0.02), whereas EF was not. After adjustment for multiple potential confounders (age, gender, race, smoking, @entity3 , @entity1 , @entity5 , @entity4 , @entity7 , and EF), @entity9 remained strongly associated with mortality (hazard ratio 1.30, 95% confidence interval 1.10 to 1.56, p  = 0.002). In  conclusion, @entity9 is an important index in @entity0 with @entity6 , which is additive to EF as a marker for mortality in this high-risk group.

title: Echocardiographic Strain and Mortality in Black Americans With XXXX on Hemodialysis.

answer: @entity6


abstract: Mosquito control using insecticides has been the most successful intervention known to reduce @entity3 prevalence or incidence. However, vector control is facing a threat due to the emergence of resistance to synthetic insecticides. Insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. In this research, the leaf aqueous leachate of Tephrosia vogelii was evaluated for its @entity0 against larvae of the most invasive mosquito worldwide, @entity2 (Diptera: Culicidae), and toward adults of the water flea, Daphnia magna (Cladocera: Crustacea) and @entity5 , two non-target aquatic organisms that share the same ecological niche of A. albopictus. The leaf aqueous leachate of T. vogelii was evaluated against fourth-instar larvae, non-blood fed 3-5 days old laboratory strains of A. albopictus under @entity4 . In addition, the objective of the present work was to study the environmental safety evaluation for aquatic ecosystem. Mortality was then recorded after 7d exposure. The leaf aqueous leachate of T. vogelii showed high mosquitocidal activity against larvae of A. albopictus, with a LC50=1.18 g/mL. However, it had a remarkable acute @entity0 also toward adults of the non-target arthropod D. magna, with a LC50=0.47 g/L and @entity5 with a LC50=5.31 g/L. The present findings have important implications in the practical control of mosquito larvae in the aquatic ecosystem, as the medicinal plants studied are commonly available in large quantities. The extract could be used in stagnant water bodies for the control of mosquitoes acting as vector for many @entity1 .

title: Laboratory evaluation of aqueous leaf extract of Tephrosia vogelii against larvae of XXXX (Diptera: Culicidae) and non-target aquatic organisms.

answer: @entity2


abstract: BACKGROUND: The evaluation of the interaction of @entity0 , venous endothelial cells (HUVEC) with body foreign materials on the cellular level cannot be performed in vivo, but is investigated in vitro under standard culture conditions. To maintain the vitality, proliferation and morphology of HUVEC seeded on body foreign substrates over days, the cell culture medium is usually exchanged every second day. It is well known, that alterations in the microenvironment of cells bear the risk of influencing cell morphology and function. In the current study the influence of cell culture medium exchange on HUVEC cytoskeletal microfilament structure and function was investigated. MATERIAL AND METHODS: HUVEC in the third passage were seeded on extracellular matrix (ECM) - which was secreted from @entity1 corneal endothelial cells on glass- until functional confluence was reached. The experiment started 11 days after HUVEC seeding with an exchange of the cell culture medium followed by a staining of the actin microfilaments with @entity3 -rhodamin 1.5 and 5 minutes after medium exchange. The microfilaments were documented by use of an Olympus microscope (IMT-2) equipped with a UV lamp and online connected to a TV chain (Sony XC 50 ST/monochrome) implying an OPTIMAS - Image analysis system. @entity2 was analysed in the cell culture supernatant. RESULTS: 1.5min after culture medium exchange in the functionally confluent cultures a slight disturbance of the actin microfilament structure with a broadening of the marginal filament band, a partial disconnection of cell-cell contacts and the appearance of intercellular fenestrations were observed. 5 minutes after medium exchange a redevelopment of the slightly disturbed microfilament structure with a condensation and narrowing of the marginal filament band was seen. 12h later a further consolidation of the microfilament structure occurred. In addition, a perturbation of the cultured HUVEC occurred after cell culture medium exchange. The @entity2 concentration in the supernatant increased significantly after 1.5min to 466    543 pg  mL-1 (p< 0.001) and after 5min to 408    458 pg  mL-1 (p< 0.001), while in control cells the @entity2 concentration did not change remaining in the range of 50    48.9 pg  mL-1. CONCLUSION: This study revealed that the exchange of the cell culture medium led to a rapid disturbance of the HUVEC with stress fiber formation, disconnection of cell-cell contacts and an altered @entity2 secretion, which had regressed nearly completely after 12 hours. Therefore, the evaluation of HUVEC on body foreign materials should be performed not earlier than 12 hours after cell culture medium exchange to avoid a misinterpretation of the endothelial cell morphological state. This procedure minimizes the risk of a misinterpretation of the endothelial cell morphology - caused by the culture medium exchange and not by the interaction between biomaterials and HUVEC.

title: Morphology of primary XXXX venous endothelial cell cultures before and after culture medium exchange.

answer: @entity0


abstract: OBJECTIVE: This study used a @entity0 model of post-traumatic @entity3 ( @entity2 ) created by anterior cruciate ligament transection with partial medial meniscectomy (ACLT  +  pMMx). In this model, mild to moderate structural changes that are typical of knee @entity2 have been observed within 2 and 8  weeks post-surgery. We aimed to determine whether @entity1 can distinguish between an ACLT  +  pMMx and a sham surgery group. DESIGN: Three-month old male @entity0 underwent ACLT  +  pMMx on their right hindlimb within two groups of n  =  6 each, and sham surgery within two groups of n  =  5 each. Assessments evaluated percent ipsilateral weight-bearing for static weight-bearing and 18 different variables of exploratory motor behaviour at multiple time points between 1 and 8  weeks post-surgery. Histology was performed on the right hindlimbs at 4 and 8  weeks post-surgery. RESULTS: Histology confirmed mild to moderate knee @entity2 changes in the ACLT  +  pMMx group and the absence of knee @entity2 changes in the sham group. Compared to the sham group, the ACLT  +  pMMx group had significantly lower percent ipsilateral weight-bearing from 1 through 8  weeks post-surgery. Compared to the sham group, the ACLT  +  pMMx group had significantly lower vertical activity (episode count, time, and count) values. CONCLUSIONS: These findings suggest that ipsilateral weight-bearing deficit and vertical activity limitations resulted from the presence of knee @entity2 -like changes in this model. When using the ACLT  +  pMMx-induced @entity0 model of knee @entity2 , percent ipsilateral weight-bearing and vertical activity distinguished between @entity0 with and without knee @entity2 changes. These variables may be useful outcome measures in preclinical research performed with this experimental post-traumatic knee @entity2 model.

title: Weight-bearing asymmetry and vertical activity differences in a @entity0 model of post-traumatic XXXX .

answer: @entity3


abstract: OBJECTIVE: This study used a @entity0 model of post-traumatic @entity3 ( @entity2 ) created by anterior cruciate ligament transection with partial medial meniscectomy (ACLT  +  pMMx). In this model, mild to moderate structural changes that are typical of knee @entity2 have been observed within 2 and 8  weeks post-surgery. We aimed to determine whether @entity1 can distinguish between an ACLT  +  pMMx and a sham surgery group. DESIGN: Three-month old male @entity0 underwent ACLT  +  pMMx on their right hindlimb within two groups of n  =  6 each, and sham surgery within two groups of n  =  5 each. Assessments evaluated percent ipsilateral weight-bearing for static weight-bearing and 18 different variables of exploratory motor behaviour at multiple time points between 1 and 8  weeks post-surgery. Histology was performed on the right hindlimbs at 4 and 8  weeks post-surgery. RESULTS: Histology confirmed mild to moderate knee @entity2 changes in the ACLT  +  pMMx group and the absence of knee @entity2 changes in the sham group. Compared to the sham group, the ACLT  +  pMMx group had significantly lower percent ipsilateral weight-bearing from 1 through 8  weeks post-surgery. Compared to the sham group, the ACLT  +  pMMx group had significantly lower vertical activity (episode count, time, and count) values. CONCLUSIONS: These findings suggest that ipsilateral weight-bearing deficit and vertical activity limitations resulted from the presence of knee @entity2 -like changes in this model. When using the ACLT  +  pMMx-induced @entity0 model of knee @entity2 , percent ipsilateral weight-bearing and vertical activity distinguished between @entity0 with and without knee @entity2 changes. These variables may be useful outcome measures in preclinical research performed with this experimental post-traumatic knee @entity2 model.

title: Weight-bearing asymmetry and vertical activity differences in a XXXX model of post-traumatic @entity3 .

answer: @entity0


abstract: UNASSIGNED: @entity4 is a common and serious @entity7 that lacks a pharmaceutical intervention to improve long-term outcome. @entity6 is implicated in some of the consequences of @entity4 and is a potential pharmacological target. Protein phosphatase 2A is a heterotrimeric protein that regulates key signalling pathways, and protein phosphatase 2A heterotrimers consisting of the PR55 B-subunit represent the major tau phosphatase in the brain. Here we investigated whether @entity4 in @entity2 and @entity0 would induce changes in protein phosphatase 2A and phosphorylated tau, and whether treatment with @entity8 -a potent PR55 activator-would reduce phosphorylated tau and improve @entity4 outcomes in @entity2 . Ninety young adult male Long-Evans @entity2 were administered either a fluid percussion injury or sham-injury. A proportion of @entity2 were killed at 2, 24, and 72 h post-injury to assess acute changes in protein phosphatase 2A and tau. Other @entity2 were given either @entity8 or saline-vehicle treatment that was continuously administered via subcutaneous osmotic pump for 12 weeks. Serial magnetic resonance imaging was acquired prior to, and at 1, 4, and 12 weeks post-injury to assess evolving structural @entity3 and @entity1 . Behavioural impairments were assessed at 12 weeks post-injury. The results showed that @entity4 in @entity2 acutely reduced PR55 expression and protein phosphatase 2A activity, and increased the expression of phosphorylated tau and the ratio of phosphorylated tau to total tau. Similar findings were seen in post-mortem brain samples from acute @entity0 @entity4 @entity0 , although many did not reach statistical significance. Continuous @entity8 treatment for 12 weeks after sham or fluid percussion injury in @entity2 increased protein phosphatase 2A activity and PR55 expression, and reduced the ratio of phosphorylated tau to total tau, attenuated @entity3 , and improved behavioural outcomes in @entity2 given a fluid percussion injury. Notably, total tau levels were decreased in @entity2 12 weeks after fluid percussion injury, and several other factors, including the use of anaesthetic, the length of recovery time, and that some @entity5 and behavioural dysfunction still occurred in @entity2 treated with @entity8 must be considered in the interpretation of this study. However, taken together these data suggest protein phosphatase 2A and hyperphosphorylated tau may be involved in the neurodegenerative cascade of @entity4 , and support the potential use of @entity8 as a novel @entity4 therapy.

title: @entity8 reduces hyperphosphorylated tau and improves outcomes after XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity4 is a common and serious @entity7 that lacks a pharmaceutical intervention to improve long-term outcome. @entity6 is implicated in some of the consequences of @entity4 and is a potential pharmacological target. Protein phosphatase 2A is a heterotrimeric protein that regulates key signalling pathways, and protein phosphatase 2A heterotrimers consisting of the PR55 B-subunit represent the major tau phosphatase in the brain. Here we investigated whether @entity4 in @entity2 and @entity0 would induce changes in protein phosphatase 2A and phosphorylated tau, and whether treatment with @entity8 -a potent PR55 activator-would reduce phosphorylated tau and improve @entity4 outcomes in @entity2 . Ninety young adult male Long-Evans @entity2 were administered either a fluid percussion injury or sham-injury. A proportion of @entity2 were killed at 2, 24, and 72 h post-injury to assess acute changes in protein phosphatase 2A and tau. Other @entity2 were given either @entity8 or saline-vehicle treatment that was continuously administered via subcutaneous osmotic pump for 12 weeks. Serial magnetic resonance imaging was acquired prior to, and at 1, 4, and 12 weeks post-injury to assess evolving structural @entity3 and @entity1 . Behavioural impairments were assessed at 12 weeks post-injury. The results showed that @entity4 in @entity2 acutely reduced PR55 expression and protein phosphatase 2A activity, and increased the expression of phosphorylated tau and the ratio of phosphorylated tau to total tau. Similar findings were seen in post-mortem brain samples from acute @entity0 @entity4 @entity0 , although many did not reach statistical significance. Continuous @entity8 treatment for 12 weeks after sham or fluid percussion injury in @entity2 increased protein phosphatase 2A activity and PR55 expression, and reduced the ratio of phosphorylated tau to total tau, attenuated @entity3 , and improved behavioural outcomes in @entity2 given a fluid percussion injury. Notably, total tau levels were decreased in @entity2 12 weeks after fluid percussion injury, and several other factors, including the use of anaesthetic, the length of recovery time, and that some @entity5 and behavioural dysfunction still occurred in @entity2 treated with @entity8 must be considered in the interpretation of this study. However, taken together these data suggest protein phosphatase 2A and hyperphosphorylated tau may be involved in the neurodegenerative cascade of @entity4 , and support the potential use of @entity8 as a novel @entity4 therapy.

title: XXXX reduces hyperphosphorylated tau and improves outcomes after @entity4 .

answer: @entity8


abstract: OBJECTIVE: Deep brain stimulation of the globus pallidus internus ( @entity4 -DBS) is an efficient and safe treatment for medically refractory @entity2 . However, recent studies reported gait problems, falls and @entity1 in @entity0 after the DBS procedure. The aim of this study was to quantify the effect of @entity4 -DBS on postural performance in @entity0 with @entity3 . METHODS: Thirteen @entity0 with focal @entity2 and @entity4 -DBS participated in the study. We performed two postural tests (pull test and push and release test) in on- and off-stimulation conditions and recorded the movements of the @entity0 with inertial sensors. RESULTS: Under stimulation @entity0 exhibited a higher number of steps (p=0.015), reduced first step length (p=0.011) and lower stepping velocity (p=0.001), compared to off stimulation. We observed a higher number of steps in the push and release test compared to the pull test (p=0.038). The interaction between stimulation condition and test type was significant (p=0.027). CONCLUSIONS: The velocity and amplitude of postural reactions are compromised by @entity4 -DBS in @entity0 with @entity3 . SIGNIFICANCE: This information corresponds to @entity0 's reports of falls and postural instability after @entity4 -DBS. Pre-operatively, @entity0 should be informed about the possibility of the occurrence of such phenomena.

title: Postural stability under globus pallidus internus stimulation for XXXX .

answer: @entity2


abstract: OBJECTIVE: To determine whether @entity0 with @entity2 are less likely than unaffected controls to have had one or more endoscopic procedures (flexible sigmoidoscopy, colonoscopy, or polypectomy) before being diagnosed with @entity1 . DESIGN: Case-control study. SETTING: Hospitals of the Department of Veterans Affairs. @entity0 : 8722 and 7629 case- @entity0 with @entity3 , respectively, and age-, sex-, race-matched controls who were discharged at the same time as the corresponding case- @entity0 . MEASUREMENTS: Number and type of endoscopic procedures of the large bowel done from 1981 until the development of @entity2 in each case- @entity0 . The influence of endoscopic procedures on the development of @entity2 was tested by conditional multiple logistic regression analysis. RESULTS: Compared with controls, @entity0 with @entity2 were less likely to have had an endoscopic procedure of the large bowel before being diagnosed with @entity1 (odds ratio for @entity3 , 0.51 [95% CI, 0.44 to 0.58]; odds ratio for @entity1 , 0.55 [CI, 0.47 to 0.64]). In @entity0 who had flexible sigmoidoscopy, colonoscopy, and polypectomy, the odds ratios were even smaller. When analyzed by separate 1-year intervals, @entity0 with @entity1 had significantly fewer procedures during periods of up to 6 years before their onset of their @entity1 . Similarly, fewer inpatient and outpatient procedures were done in @entity0 than in controls. CONCLUSIONS: Endoscopic procedures of the large bowel reduce the risk for developing @entity3 by 50%, their protective influence lasting 6 years.

title: Prevention of XXXX by flexible endoscopy and polypectomy. A case-control study of 32,702 veterans.

answer: @entity2


abstract: UNASSIGNED: The relationship between @entity3 genetic polymorphisms and essential @entity1 (EH) remains unclear. The aim of this study was to investigate the association of @entity3 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 @entity0 (270 EH @entity0 and 288 controls) and a Uighur population including 473 @entity0 (181 EH @entity0 and 292 controls) were selected. Five single-nucleotide polymorphisms (SNPs) ( @entity4 , @entity5 , @entity6 , @entity7 , and @entity8 ) were genotyped using real-time PCR (TaqMan). In the Uighur population, for the total and the @entity0 , @entity4 , @entity6 and @entity7 were found to be associated with EH ( @entity4 : P <=0.02, @entity6 : P <=0.002, @entity7 : P <=0.004, respectively). The difference remained statistically significant after the multivariate adjustment (all P<0.05). The overall distributions of the haplotypes established by @entity2 -SNP3, @entity2 -SNP4, @entity2 -SNP3-SNP5 and @entity2 -SNP4-SNP5 were significantly different between the EH @entity0 and the control subjects (for the total: P=0.013, P=0.008, P=0.032, P=0.010, for @entity0 : P<0.001, P=0.001, P=0.010, P=0.00). In the Han population, for @entity0 , @entity8 was found to be associated with EH in a recessive model (P=0.007); the significant difference was not retained after the adjustment for the covariates (date not shown). The A allele of @entity4 could be a susceptible genetic marker, and the T allele of @entity7 could be a protective genetic marker of EH. The AC genotype of @entity4 , the AG genotype of @entity6 and the TT genotype of @entity7 could be protective genetic markers of EH.

title: Relationship between XXXX Genetic Polymorphism and Essential @entity1 in a Chinese Population.

answer: @entity3


abstract: UNASSIGNED: The relationship between @entity3 genetic polymorphisms and essential @entity1 (EH) remains unclear. The aim of this study was to investigate the association of @entity3 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 @entity0 (270 EH @entity0 and 288 controls) and a Uighur population including 473 @entity0 (181 EH @entity0 and 292 controls) were selected. Five single-nucleotide polymorphisms (SNPs) ( @entity4 , @entity5 , @entity6 , @entity7 , and @entity8 ) were genotyped using real-time PCR (TaqMan). In the Uighur population, for the total and the @entity0 , @entity4 , @entity6 and @entity7 were found to be associated with EH ( @entity4 : P <=0.02, @entity6 : P <=0.002, @entity7 : P <=0.004, respectively). The difference remained statistically significant after the multivariate adjustment (all P<0.05). The overall distributions of the haplotypes established by @entity2 -SNP3, @entity2 -SNP4, @entity2 -SNP3-SNP5 and @entity2 -SNP4-SNP5 were significantly different between the EH @entity0 and the control subjects (for the total: P=0.013, P=0.008, P=0.032, P=0.010, for @entity0 : P<0.001, P=0.001, P=0.010, P=0.00). In the Han population, for @entity0 , @entity8 was found to be associated with EH in a recessive model (P=0.007); the significant difference was not retained after the adjustment for the covariates (date not shown). The A allele of @entity4 could be a susceptible genetic marker, and the T allele of @entity7 could be a protective genetic marker of EH. The AC genotype of @entity4 , the AG genotype of @entity6 and the TT genotype of @entity7 could be protective genetic markers of EH.

title: Relationship between @entity3 Genetic Polymorphism and Essential XXXX in a Chinese Population.

answer: @entity1


abstract: PURPOSE: To report 6-month, 1- and 2-year endothelial cell loss (ECL), @entity2 in a large series of @entity0 undergoing either Descemets stripping endothelial keratoplasty (DSEK) or a combined phacoemulsification and DSEK in a UK centre. @entity0 AND METHODS: @entity0 undergoing DSEK with or without concurrent @entity1 surgery were included in this retrospective study. Surgeries were performed between January 2006 and May 2013. Main outcomes included @entity2 and percentage ECL. RESULTS: DSEK was performed in 226 eyes (210 @entity0 ). Of these, 141 eyes (126 @entity0 ) underwent DSEK alone and 85 eyes (84 @entity0 ) underwent DSEK combined with @entity1 surgery. Excluding complex anterior segment pathology the mean percentage ECL at 6, 12 and 24 months was 40.5  13.4, 45.1  14.6 and 53.1  13.0 in the DSEK group and 40.7  15.4, 42.6  15.3 and 49.6  16.5 in @entity0 undergoing the combined procedure, respectively. There was no significant difference in percentage ECL at 6 or 24 months between the two groups both in complex and routine cases. @entity3 occurred in four @entity0 undergoing DSEK and three undergoing combined procedure. @entity2 rates did not reach statistical significance between the groups. CONCLUSION: Mean ECL and complication rates were comparable at 6, 12 and 24 months in routine cases undergoing concurrent DSEK with @entity1 surgery and those undergoing DSEK. These data support the combined procedure in @entity0 requiring both @entity1 surgery and endothelial keratoplasty. Further collaboration to report endothelial cell counts from other UK centres should be encouraged.

title: Endothelial cell loss and complication rates with combined Descemets stripping endothelial keratoplasty and XXXX surgery in a UK centre.

answer: @entity1


abstract: @entity3 ( @entity3 ) has been found to be closely associated with many types of @entity0 @entity1 and often shows strong correlations with specific @entity1 features. However, the relationship between @entity3 and @entity1 are still unclear. The aim of the present study is to explore the relationships between @entity3 , @entity1 formation under the mutagenic effects of @entity7 ( @entity8 ). @entity2 were administered with either @entity8 (90mg/kg) or PBS and @entity5 (control) at the beginning of the 1st week of the experiment. Of the 31 @entity2 that survived the entire experimental time course, 19 (61.3%) @entity2 developed @entity6 . In addition, 52.6% (10/19) of the @entity1 had metastasized to the liver. We detected @entity3 in @entity8 -treated @entity2 using a panel of 42 mutation-sensitive loci. Nineteen loci (45.2%) in six organs showed 70 @entity3 events. Locus D8Mit14 showed enhanced @entity3 compared with the other examined loci. @entity3 frequency in thymus was higher than in other organs. Interestingly, there was no significant difference observed between the metastatic and non-metastatic livers. The @entity3 frequency (4.6%, 23/(42*12)) in the @entity8 -treated thymus that had never developed @entity1 was significantly higher than this in the thymus that had developed @entity4 (0.5%, 4/(42*19)) (p<0.0001). These results indicate that, although thymic tumorigenesis is associated with @entity3 , it occurs with higher frequency in these that have not developed @entity1 upon the @entity8 -treatment. Our study provides additional insights into the relationship between @entity3 occurrence and tumorigenesis.

title: Analysis of the relationship between microsatellite instability and XXXX induced by @entity7 in C57BL/6J @entity2 .

answer: @entity6


abstract: @entity3 ( @entity3 ) has been found to be closely associated with many types of @entity0 @entity1 and often shows strong correlations with specific @entity1 features. However, the relationship between @entity3 and @entity1 are still unclear. The aim of the present study is to explore the relationships between @entity3 , @entity1 formation under the mutagenic effects of @entity7 ( @entity8 ). @entity2 were administered with either @entity8 (90mg/kg) or PBS and @entity5 (control) at the beginning of the 1st week of the experiment. Of the 31 @entity2 that survived the entire experimental time course, 19 (61.3%) @entity2 developed @entity6 . In addition, 52.6% (10/19) of the @entity1 had metastasized to the liver. We detected @entity3 in @entity8 -treated @entity2 using a panel of 42 mutation-sensitive loci. Nineteen loci (45.2%) in six organs showed 70 @entity3 events. Locus D8Mit14 showed enhanced @entity3 compared with the other examined loci. @entity3 frequency in thymus was higher than in other organs. Interestingly, there was no significant difference observed between the metastatic and non-metastatic livers. The @entity3 frequency (4.6%, 23/(42*12)) in the @entity8 -treated thymus that had never developed @entity1 was significantly higher than this in the thymus that had developed @entity4 (0.5%, 4/(42*19)) (p<0.0001). These results indicate that, although thymic tumorigenesis is associated with @entity3 , it occurs with higher frequency in these that have not developed @entity1 upon the @entity8 -treatment. Our study provides additional insights into the relationship between @entity3 occurrence and tumorigenesis.

title: Analysis of the relationship between microsatellite instability and @entity6 induced by XXXX in C57BL/6J @entity2 .

answer: @entity7


abstract: @entity3 ( @entity3 ) has been found to be closely associated with many types of @entity0 @entity1 and often shows strong correlations with specific @entity1 features. However, the relationship between @entity3 and @entity1 are still unclear. The aim of the present study is to explore the relationships between @entity3 , @entity1 formation under the mutagenic effects of @entity7 ( @entity8 ). @entity2 were administered with either @entity8 (90mg/kg) or PBS and @entity5 (control) at the beginning of the 1st week of the experiment. Of the 31 @entity2 that survived the entire experimental time course, 19 (61.3%) @entity2 developed @entity6 . In addition, 52.6% (10/19) of the @entity1 had metastasized to the liver. We detected @entity3 in @entity8 -treated @entity2 using a panel of 42 mutation-sensitive loci. Nineteen loci (45.2%) in six organs showed 70 @entity3 events. Locus D8Mit14 showed enhanced @entity3 compared with the other examined loci. @entity3 frequency in thymus was higher than in other organs. Interestingly, there was no significant difference observed between the metastatic and non-metastatic livers. The @entity3 frequency (4.6%, 23/(42*12)) in the @entity8 -treated thymus that had never developed @entity1 was significantly higher than this in the thymus that had developed @entity4 (0.5%, 4/(42*19)) (p<0.0001). These results indicate that, although thymic tumorigenesis is associated with @entity3 , it occurs with higher frequency in these that have not developed @entity1 upon the @entity8 -treatment. Our study provides additional insights into the relationship between @entity3 occurrence and tumorigenesis.

title: Analysis of the relationship between microsatellite instability and @entity6 induced by @entity7 in C57BL/6J XXXX .

answer: @entity2


abstract: The purpose of this study was to examine the effect of circulating @entity5 on neuroendocrine, autonomic, and behavioral responses to stress. The effects of conditioned stress were studied in male @entity0 that were intact, gonadectomized, or gonadectomized and treated with @entity1 ( @entity2 ). Intact animals received sham surgeries. Animals were stressed 3 wk after surgery. The adrenocorticotropic hormone (ACTH) response to conditioned stress was significantly potentiated (P < 0.01) in gonadectomized males compared with sham-operated and gonadectomized @entity2 -treated animals. In stressed @entity0 , plasma @entity3 levels were significantly higher (P < 0.05) in gonadectomized animals compared with @entity2 -treated castrates. The prolactin response to stress was decreased (P < 0.01) in gonadectomized males compared with sham-operated and gonadectomized @entity2 -treated @entity0 . The stress-induced increases in plasma @entity4 activity and concentration were not altered in gonadectomized or in gonadectomized @entity2 -treated animals. Nonstressed @entity2 -treated castrates exhibited more "fearlike" behavior compared with nonstressed sham-operated and gonadectomized animals. However, conditioned stress produced the same behavioral effects in all treatment groups. The results demonstrate that the ACTH/ @entity3 , prolactin, and behavioral responses to a psychological stressor are differentially regulated by circulating @entity5 .

title: Castration attenuates prolactin response but potentiates ACTH response to conditioned stress in the XXXX .

answer: @entity0


abstract: BACKGROUND: Blastic plasmacytoid @entity3 (BPDCN) is a rare @entity4 that was once believed to be derived from natural killer cells and is now recognized as originating from precursors of plasmacytoid dendritic cells. It generally involves the skin and has an aggressive clinical course. Due to its highly malignant behavior, a fast and accurate diagnosis of this condition is of the utmost importance. METHODS: Six cytology specimens from 5 @entity0 diagnosed with BPDCN were reviewed as well as their clinical records. Findings were compared with 3 previously published cases. RESULTS: Two exfoliative cytology specimens (cerebrospinal fluid) and 4 fine-needle aspiration specimens (3 lymph node specimens and 1 cutaneous specimen) were reviewed. The cytomorphological aspects were similar in all cases. The smears were hypercellular with a monotonous population of intermediate-sized cells, dispersed singly or arranged in loose aggregates. The cells had round to oval nuclei, with fine chromatin and prominent nucleoli; the cytoplasm was generally scant, without visible granules. Intracytoplasmic microvacuoles were found in the majority of cases. Four cases were also characterized by flow cytometry, which revealed expression of @entity6 , @entity5 and/or @entity2 . Fine-needle aspiration was used in 1 case for primary diagnosis. Histological confirmation was available in all cases. CONCLUSIONS: BPDCN is a highly malignant @entity1 with a poor outcome. Cytology, in association with flow cytometry immunophenotyping and clinical history, is a reliable method with which to establish the diagnosis. @entity1 ( @entity1 Cytopathol) 2015.    2015 American @entity1 Society.

title: Cytomorphological features of XXXX on FNA and cerebrospinal fluid cytology: A review of 6 cases.

answer: @entity3


abstract: Atraumatic @entity8 is an uncommon complication of @entity4 . This report describes the case of a 30-year-old @entity0 with @entity4 and @entity5 complicated by @entity8 . The @entity0 was admitted to the emergency department with @entity2 in the upper abdomen that had been present for six hours and was associated with @entity3 and sweating. He was diagnosed with @entity4 of alcoholic etiology. Upon computed tomography (CT) of the abdomen, the @entity6 was scored as Balthazar C grade, and a suspicious area of @entity1 affecting 30% of the pancreas with @entity5 was revealed. Seventy-two hours after admission, the @entity0 had significant improvement in symptoms. However, he showed clinical worsening on the sixth day of hospitalization, with increasing abdominal distension and reduced hemoglobin levels. A CT angiography showed a large amount of free fluid in the abdominal cavity, along with a large splenic @entity7 and contrast extravasation along the spleen artery. The @entity0 subsequently underwent laparotomy, which showed hemoperitoneum due to @entity8 . A splenectomy was then performed, followed by ultrasound-guided percutaneous drainage.

title: Acute XXXX complicated with @entity8 : A case report.

answer: @entity6


abstract: Atraumatic @entity8 is an uncommon complication of @entity4 . This report describes the case of a 30-year-old @entity0 with @entity4 and @entity5 complicated by @entity8 . The @entity0 was admitted to the emergency department with @entity2 in the upper abdomen that had been present for six hours and was associated with @entity3 and sweating. He was diagnosed with @entity4 of alcoholic etiology. Upon computed tomography (CT) of the abdomen, the @entity6 was scored as Balthazar C grade, and a suspicious area of @entity1 affecting 30% of the pancreas with @entity5 was revealed. Seventy-two hours after admission, the @entity0 had significant improvement in symptoms. However, he showed clinical worsening on the sixth day of hospitalization, with increasing abdominal distension and reduced hemoglobin levels. A CT angiography showed a large amount of free fluid in the abdominal cavity, along with a large splenic @entity7 and contrast extravasation along the spleen artery. The @entity0 subsequently underwent laparotomy, which showed hemoperitoneum due to @entity8 . A splenectomy was then performed, followed by ultrasound-guided percutaneous drainage.

title: Acute @entity6 complicated with XXXX : A case report.

answer: @entity8


abstract: OBJECTIVES: Our aim is to investigate socioeconomic disparities in cervical @entity1 screening utilization among and between ethnic groups in the United States. STUDY DESIGN: Observational study. METHODS: Data on 26,338 @entity0 aged 21 to 64 years were obtained from the 2007 to 2011 years of the Medical Expenditure Panel Survey. Data on cervical @entity1 screening utilization in the preceding 12 months and 3 years, and a range of sociodemographic characteristics were included. Analyses were undertaken for all @entity0 and across racial/ethnic grouping (ie, white, black, Hispanic, and other). Concentration indices were used to measure the socioeconomic gradient across ethnic groups. Probit regression analyses were used to examine variations in utilization related to socioeconomic factors across ethnic groups controlling for a range of pertinent characteristics. RESULTS: Annual utilization rates are high in the United States (60.15%) and greatest among black @entity0 (66.25%). Disparities, as measured by concentration indices (CIs), are large in the United States, with the largest being for white @entity0 (CI, 0.179) relative to black (CI, 0.103) and Hispanic (CI, 0.081) @entity0 . Screening differences across income, education and insurance status are also greater amongst white @entity0 . CONCLUSIONS: Uptake of cervical @entity1 screening is common in the United States, with large socioeconomic disparities also evident. Those from lower socioeconomic or uninsured groups who are most likely to have, and to die from, cervical @entity1 , are least likely to use preventive screening. Disparities differ across ethnic groups and are greatest amongst white @entity0 . Incorporating organized screening may serve to improve both the systems efficiency and address disparities between and within groups.

title: Socioeconomic disparities across ethnicities: an application to cervical XXXX screening.

answer: @entity1


abstract: UNASSIGNED: Rheumatoid factors (RF) and the disease-specific anti-citrullinated protein autoantibodies ( @entity13 ) coexist in the joints of @entity2 ( @entity2 ) @entity0 where they probably contribute to @entity5 . We investigated the influence of IgM and IgA RF on the FcR- and complement-dependent effects of @entity13 immune complexes ( @entity13 -IC). When stimulated by @entity13 -IC formed in the presence of IgM RF or IgA RF fractions purified from @entity2 serum pools, @entity12 -generated macrophages skewed their cytokine response toward @entity1 , with increases in the @entity3 / @entity8 ratio and in @entity6 and @entity7 secretion, and decreases in the @entity9 / @entity10 ratio. In the IgM RF-mediated amplification of the inflammatory response of macrophages, the participation of an IgM receptor was excluded, notably by showing that they did not express any established receptor for IgM. Rather, this amplification depended on the IgM RF-mediated recruitment of more IgG into the @entity13 -IC. However, the macrophages expressed FcaRI and blocking its interaction with IgA inhibited the IgA RF-mediated amplification of @entity3 secretion induced by @entity13 -IC, showing its major implication in the effects of RF of the IgA class. @entity4 further amplified the @entity3 response of macrophages to RF-containing @entity13 -IC. Lastly, the presence of IgM or IgA RF increased the capacity of @entity13 -IC to activate the complement cascade. Therefore, specifically using autoantibodies from @entity2 @entity0 , the strong FcR-mediated or complement-dependent pathogenic potential of IC including both @entity13 and IgM or IgA RF was established. Simultaneous FcR triggering by these RF-containing @entity13 -IC and @entity11 ligation possibly makes a major contribution to @entity2 .

title: IgM and IgA Rheumatoid Factors Purified from XXXX Sera Boost the Fc Receptor- and Complement-Dependent Effector Functions of the Disease-Specific Anti-Citrullinated Protein Autoantibodies.

answer: @entity2


abstract: BACKGROUND: Few reports exist regarding @entity4 where the initial work up was concerning for a @entity1 . To date, no published reports exist regarding a nongiant thrombosed @entity3 , where the primary workup and treatment plan was directed toward a preliminary diagnosis of @entity1 . CASE DESCRIPTION: We report a 43-year-old female who presented with a generalized @entity2 attributed to a lesion along the right superior temporal gyrus. The lesion enhanced on initial magnetic resonance imaging (MRI) of the brain, as well as on follow-up MRI. Subsequent vascular studies and metastatic work up were negative. A craniotomy with image guidance was performed and an intraoperative diagnosis was made of a thrombosed @entity4 along a branch of the middle cerebral artery. The @entity4 was trapped and resected as there was no significant flow from the branch as seen on the prior cerebral angiogram. The @entity0 had an uneventful postoperative course. CONCLUSION: Completely thrombosed, nongiant @entity4 can mimic an @entity1 . Typical imaging features for @entity4 may be missed, especially if the @entity4 are small, where imaging characteristics of the intraluminal contents is more difficult to appreciate. Although imaging may be consistent with a @entity5 , there should be suspicion for a potential underlying @entity4 .

title: A completely thrombosed, nongiant XXXX mimicking an @entity1 .

answer: @entity3


abstract: BACKGROUND: Few reports exist regarding @entity4 where the initial work up was concerning for a @entity1 . To date, no published reports exist regarding a nongiant thrombosed @entity3 , where the primary workup and treatment plan was directed toward a preliminary diagnosis of @entity1 . CASE DESCRIPTION: We report a 43-year-old female who presented with a generalized @entity2 attributed to a lesion along the right superior temporal gyrus. The lesion enhanced on initial magnetic resonance imaging (MRI) of the brain, as well as on follow-up MRI. Subsequent vascular studies and metastatic work up were negative. A craniotomy with image guidance was performed and an intraoperative diagnosis was made of a thrombosed @entity4 along a branch of the middle cerebral artery. The @entity4 was trapped and resected as there was no significant flow from the branch as seen on the prior cerebral angiogram. The @entity0 had an uneventful postoperative course. CONCLUSION: Completely thrombosed, nongiant @entity4 can mimic an @entity1 . Typical imaging features for @entity4 may be missed, especially if the @entity4 are small, where imaging characteristics of the intraluminal contents is more difficult to appreciate. Although imaging may be consistent with a @entity5 , there should be suspicion for a potential underlying @entity4 .

title: A completely thrombosed, nongiant @entity3 mimicking an XXXX .

answer: @entity1


abstract: UNASSIGNED: Antibiotic resistance is the major cause for @entity1 eradication failure. @entity1 @entity2 resistance mutations were evaluated in 84 (82 phenotypically @entity2 resistant and 2 intermediately susceptible) strains by allele-specific PCR and 3'-mismatched PCR. Many (57.1%) of these strains were @entity0 resistant. Prevalence of cagA(+), cagE(+), vacA s1a, m1, i1, and i2 strains was 76.2%, 58.0%, 82.1%, 35.7%, 50.0%, and 50.0%, respectively. @entity3 , @entity4 , @entity5 , and @entity3 + @entity4 mutation rates were 64.3%, 23.8%, 1.2%, and 10.7%, respectively. Strains harboring the @entity4 mutation showed 5.3-fold higher @entity2 MIC50 than those harboring the @entity3 mutation. The @entity3 mutation alone was 1.7-fold more common in vacA i2 strains compared with vacA i1 strains, while the @entity4 mutation alone was 3-fold more frequent in vacA i1 strains than vacA i2 strains and 3.1-fold more common in @entity0 -susceptible compared with @entity0 -resistant strains. Briefly, @entity2 resistance mutations were significantly linked to vacA i allele and @entity0 susceptibility. This is the first report about associations between the @entity3 mutation and less virulent vacA i2 strains, and between the @entity4 mutation and more virulent vacA i1 strains. As the 2143G mutation often predicts eradication failure by @entity2 -based regimens, the results may be linked to the better eradication of more virulent strains compared with the less virulent strains.

title: XXXX Resistance Mutations in @entity1 in Association with Virulence Factors and Antibiotic Susceptibility of the Strains.

answer: @entity2


abstract: UNASSIGNED: Antibiotic resistance is the major cause for @entity1 eradication failure. @entity1 @entity2 resistance mutations were evaluated in 84 (82 phenotypically @entity2 resistant and 2 intermediately susceptible) strains by allele-specific PCR and 3'-mismatched PCR. Many (57.1%) of these strains were @entity0 resistant. Prevalence of cagA(+), cagE(+), vacA s1a, m1, i1, and i2 strains was 76.2%, 58.0%, 82.1%, 35.7%, 50.0%, and 50.0%, respectively. @entity3 , @entity4 , @entity5 , and @entity3 + @entity4 mutation rates were 64.3%, 23.8%, 1.2%, and 10.7%, respectively. Strains harboring the @entity4 mutation showed 5.3-fold higher @entity2 MIC50 than those harboring the @entity3 mutation. The @entity3 mutation alone was 1.7-fold more common in vacA i2 strains compared with vacA i1 strains, while the @entity4 mutation alone was 3-fold more frequent in vacA i1 strains than vacA i2 strains and 3.1-fold more common in @entity0 -susceptible compared with @entity0 -resistant strains. Briefly, @entity2 resistance mutations were significantly linked to vacA i allele and @entity0 susceptibility. This is the first report about associations between the @entity3 mutation and less virulent vacA i2 strains, and between the @entity4 mutation and more virulent vacA i1 strains. As the 2143G mutation often predicts eradication failure by @entity2 -based regimens, the results may be linked to the better eradication of more virulent strains compared with the less virulent strains.

title: @entity2 Resistance Mutations in XXXX in Association with Virulence Factors and Antibiotic Susceptibility of the Strains.

answer: @entity1


abstract: @entity9 was added to cardioplegia and studied for its efficacy in stabilizing the postischemic rhythm after aortic declamping in cardiac surgery. Fifty-six @entity0 scheduled for coronary artery bypass grafting (CABG), were included in a randomized, double-blind study. The @entity0 were anesthetized with @entity7 , low-dose @entity6 , @entity4 , and @entity8 . In the study group (28 @entity0 ), St. Thomas' Hospital cardioplegic solution II (Plegisol) was prepared with 1 mM @entity9 . The control group (28 @entity0 ) was given the same cardioplegia with saline. @entity3 ( @entity3 ) occurring after declamping was treated with direct current (DC) shock (8-12-12-20 J). There were no significant differences with regard to demographic properties or anesthesiologic and surgical treatment. Two @entity0 (7%) in the @entity9 group required DC shock for @entity3 , compared to 28 (100%) in the control group (P < 0.001). The amount of @entity5 (mean +/- SEM) given for resistant @entity1 was 3.6 mg +/- 3.6 in the @entity9 group compared to 35.7 mg +/- 9.2 in the control group (P < 0.002). One @entity0 in each group required temporary pacing. The number of synchronized DC shocks for conversion of @entity2 was lower in the @entity9 group (P < 0.05). The enzyme release the first day after surgery was lower in the @entity9 group (P < 0.05). @entity9 (1 mM) in cardioplegia stabilizes the postischemic rhythm in CABG surgery in @entity0 without any observed adverse effects.

title: XXXX is effective for minimizing @entity3 in cardiac surgery.

answer: @entity9


abstract: @entity9 was added to cardioplegia and studied for its efficacy in stabilizing the postischemic rhythm after aortic declamping in cardiac surgery. Fifty-six @entity0 scheduled for coronary artery bypass grafting (CABG), were included in a randomized, double-blind study. The @entity0 were anesthetized with @entity7 , low-dose @entity6 , @entity4 , and @entity8 . In the study group (28 @entity0 ), St. Thomas' Hospital cardioplegic solution II (Plegisol) was prepared with 1 mM @entity9 . The control group (28 @entity0 ) was given the same cardioplegia with saline. @entity3 ( @entity3 ) occurring after declamping was treated with direct current (DC) shock (8-12-12-20 J). There were no significant differences with regard to demographic properties or anesthesiologic and surgical treatment. Two @entity0 (7%) in the @entity9 group required DC shock for @entity3 , compared to 28 (100%) in the control group (P < 0.001). The amount of @entity5 (mean +/- SEM) given for resistant @entity1 was 3.6 mg +/- 3.6 in the @entity9 group compared to 35.7 mg +/- 9.2 in the control group (P < 0.002). One @entity0 in each group required temporary pacing. The number of synchronized DC shocks for conversion of @entity2 was lower in the @entity9 group (P < 0.05). The enzyme release the first day after surgery was lower in the @entity9 group (P < 0.05). @entity9 (1 mM) in cardioplegia stabilizes the postischemic rhythm in CABG surgery in @entity0 without any observed adverse effects.

title: @entity9 is effective for minimizing XXXX in cardiac surgery.

answer: @entity3


abstract: UNASSIGNED: We studied the processes of inhibition and facilitation in the dentate gyrus (DG) and the @entity2 field by examining the effects of paired-pulse stimulation on the evoked @entity3 ( @entity3 ) in dorsal (DH) and ventral (VH) hippocampal slices from the adult rat. The antidromic-orthodromic (A-O) and the orthodromic-orthodromic (O-O) paired-pulse stimulation protocols were used at varying inter-pulse intervals (IPI). In the DG, the A-O stimulation produced an early @entity1 of @entity3 lasting 30-40ms which was significantly stronger in the VH compared with DH. The O-O stimulation produced a biphasic pattern of effects, in both dorsal and ventral DG, consisting of an early @entity1 of @entity3 followed by facilitation at relatively longer intervals. In the DH but not the VH the phase of facilitation was followed by a late @entity1 of @entity3 (>200ms). In the @entity2 field both A-O and O-O stimulation had a biphasic effect consisting of an early phase of strong @entity1 of similar strength in DH and VH. The @entity1 was followed by a phase of facilitation which was more pronounced with O-O stimulation. The facilitation observed with the O-O stimulation was much stronger in DH than VH and in DH only it was significantly reduced by the antagonist of GABAB receptors @entity4 . Furthermore, the facilitation was insensitive to changes in [ @entity0 ]o in both hippocampal poles. These findings suggest that the dorsal compared with ventral DG is more amenable to fast-frequency input but filters out slow-frequency inputs more reliably while the gating and amplification of the excitatory input in the @entity2 circuitry is more prominent in DH than in VH.

title: Differences in paired-pulse inhibition and facilitation in the dentate gyrus and XXXX field between dorsal and ventral rat hippocampus.

answer: @entity2


abstract: BACKGROUND: Atypical antipsychotic augmentation was demonstrated to be efficacious in @entity2 ( @entity2 ) in previous meta-analyses. We investigate whether there are differences in the effect size of atypical antipsychotic augmentation in @entity1 according to the degree of treatment resistance. METHODS: A comprehensive search of four databases identified 11 randomized controlled trials. The 11 trials, which included 3 341 @entity0 , were pooled using a random-effects meta-analysis. RESULTS: Atypical antipsychotic augmentation of antidepressant therapy showed superior efficacy compared to antidepressant monotherapy in @entity2 in terms of both response and remission rates (response, risk ratio [RR] = 1.38, 95% confidence interval [CI] = 1.25 to 1.53; remission, RR = 1.62, 95% CI = 1.42 to 1.85). In addition, regarding response rates in the @entity2 trials, atypical antipsychotic augmentation exhibited significantly different effect sizes according to the degree of treatment resistance ( @entity2 1: RR = 1.24; @entity2 2: RR = 1.37; @entity2 2-4: RR = 1.58). In non- @entity2 trials, atypical antipsychotic augmentation failed to show superior efficacy over antidepressant monotherapy in terms of remission rates (RR = 0.89; 95% CI = 0.69 to 1.14). Atypical antipsychotic augmentation of antidepressant therapy exhibits greater effect size in @entity0 with a higher degree of treatment resistance. CONCLUSIONS: This finding strengthens the rationale for considering atypical antipsychotic augmentation among @entity1 @entity0 with multiple previous treatment failures in clinical practice. The efficacy of atypical antipsychotic augmentation for non- @entity2 seems to be different from that for @entity2 and, thus, further studies of non- @entity2 populations are needed.

title: Can Atypical Antipsychotic Augmentation Reduce Subsequent Treatment Failure More Effectively Among Depressed XXXX with a Higher Degree of Treatment Resistance? A Meta-Analysis of Randomized Controlled Trials.

answer: @entity0


abstract: The authors present a case report that provides support for a relationship between @entity2 and the menstrual cycle on the 1 hand and @entity5 on the other. The @entity0 in this case, a 35-year old @entity0 , suffered from a rapid cycling affective disorder that was severely affected by her menstrual cycle and responded positively to oral contraceptives (OCs). The @entity0 had a 24-year history of numerous manic and @entity3 episodes, the 1st of which coincided with menarche. She had noted that, 4 days before menses, she would experience symptoms of @entity8 ( @entity8 ) and often the onset of an affective episode. Treatment with a series of psychotropic agents had not been effective in controlling the number of episodes. However, the @entity0 reported that there had been an 8-9-month period in the past when she had taken OCs and had fewer symptoms. Thus, the @entity0 was placed on Ortho-Novum as well as @entity7 . At the 9-month follow-up, she reported there had been no further episodes of @entity3 or @entity1 . The exact mechanism behind @entity2 's psychotropic effect is unclear, although it increases the central availability of @entity4 and induces changes in dopaminergic, noradrenergic, and serotonergic receptors. @entity9 levels covary with @entity2 levels, and @entity2 seems to affect every major neurotransmitter system. The fact that @entity2 has not consistently been shown to be effective in this regard may only signify the existence of a distinct subclass of @entity5 closely linked to the menstrual cycle. This subclass may have some type of dysfunction within the @entity6 that contributes to @entity5 .

title: Antidepressant effects of XXXX .

answer: @entity2


abstract: BACKGROUND: The @entity1 Endoscopic Index of Severity (UCEIS) accounts for 86% of the variance between observers in the overall assessment of endoscopic severity, but has not been correlated with outcomes. METHODS: Consecutive cases of acute severe @entity5 (ASC) defined by Truelove and Witts (TW) criteria were retrospectively evaluated. Demographic details, number of TW criteria, prior medical therapy, UCEIS and inpatient medical therapy were recorded. Pre-specified (adverse) endpoints included rescue therapy, colectomy and readmission. RESULTS: Eighty-nine @entity0 , 48 (54%) male, mean age 38 years, all received intravenous @entity4 400mg/d (median 5 days [range 1-11]). Median follow-up was 14 months (2-33). Forty-eight (54%) were diagnosed the year prior to or at the time of admission. Thirty-six (40%) required rescue therapy (infliximab 25/36, @entity2 12/36, one receiving both). Twenty-one (24%) underwent colectomy on the index admission (9/21) or during follow-up (12/21). Median UCEIS score (possible range 0-8) was 5 (3-8). UCEIS was higher in @entity0 requiring rescue therapy or colectomy (median score 6 [range 4-8] versus 5/8 [3-8], both p < 0.005). For UCEIS >= 5, 27/54 (50%) required rescue therapy, compared with 9/33 (27%) for UCEIS  <=4 (p = 0.037). When UCEIS was >= 5, 18/54 (33%) came to colectomy during follow-up, compared with 3/33 (9%) with UCEIS  <=4. Of 14 @entity0 with UCEIS 7 or 8, 11/14 needed rescue therapy and 13/14 met any adverse endpoint. CONCLUSION: Endoscopic severity is associated with a worse outcome in ASC. When the UCEIS is >= 7 on admission, almost all @entity0 will need treatment with infliximab or @entity2 beyond @entity3 . This may mark a threshold for an early decision to use infliximab or @entity2 .

title: Association Between the @entity1 Endoscopic Index of Severity (UCEIS) and Outcomes in Acute XXXX .

answer: @entity1


abstract: BACKGROUND: The @entity1 Endoscopic Index of Severity (UCEIS) accounts for 86% of the variance between observers in the overall assessment of endoscopic severity, but has not been correlated with outcomes. METHODS: Consecutive cases of acute severe @entity5 (ASC) defined by Truelove and Witts (TW) criteria were retrospectively evaluated. Demographic details, number of TW criteria, prior medical therapy, UCEIS and inpatient medical therapy were recorded. Pre-specified (adverse) endpoints included rescue therapy, colectomy and readmission. RESULTS: Eighty-nine @entity0 , 48 (54%) male, mean age 38 years, all received intravenous @entity4 400mg/d (median 5 days [range 1-11]). Median follow-up was 14 months (2-33). Forty-eight (54%) were diagnosed the year prior to or at the time of admission. Thirty-six (40%) required rescue therapy (infliximab 25/36, @entity2 12/36, one receiving both). Twenty-one (24%) underwent colectomy on the index admission (9/21) or during follow-up (12/21). Median UCEIS score (possible range 0-8) was 5 (3-8). UCEIS was higher in @entity0 requiring rescue therapy or colectomy (median score 6 [range 4-8] versus 5/8 [3-8], both p < 0.005). For UCEIS >= 5, 27/54 (50%) required rescue therapy, compared with 9/33 (27%) for UCEIS  <=4 (p = 0.037). When UCEIS was >= 5, 18/54 (33%) came to colectomy during follow-up, compared with 3/33 (9%) with UCEIS  <=4. Of 14 @entity0 with UCEIS 7 or 8, 11/14 needed rescue therapy and 13/14 met any adverse endpoint. CONCLUSION: Endoscopic severity is associated with a worse outcome in ASC. When the UCEIS is >= 7 on admission, almost all @entity0 will need treatment with infliximab or @entity2 beyond @entity3 . This may mark a threshold for an early decision to use infliximab or @entity2 .

title: Association Between the XXXX Endoscopic Index of Severity (UCEIS) and Outcomes in Acute @entity1 .

answer: @entity1


abstract: BACKGROUND: @entity3 is a known potential complication of @entity2 . Because U.S. veterans cared for at the U.S. Department of Veterans Affairs are older and have more @entity1 ( @entity1 ) risk factors than the general U.S. population, veterans are at risk for @entity3 of @entity2 . We investigated biomarkers of @entity3 characteristics and associated @entity3 among veterans who received cardiac biomarker testing  <=30  days after laboratory-confirmed @entity7 . METHODS: Laboratory-confirmed @entity5 cases among veterans cared for at U.S. Department of Veterans Affairs' facilities for October 2010-December 2012 were identified using electronic medical records (EMRs). Influenza confirmation was based on respiratory specimen viral culture or antigen or nucleic acid detection. Acute @entity3 (ACI) was defined as an elevated cardiac biomarker (troponin I or @entity9 kinase isoenzyme MB) >99  % of the upper reference limit occurring  <=30  days after @entity5 specimen collection. EMRs were reviewed for demographics, @entity1 history and risk factors, and ACI-associated @entity3 . RESULTS: Among 38,197 @entity0 with @entity5 testing results, 4,469 (12  %) had a positive result; 600 of those @entity0 had cardiac biomarker testing performed  <=30  days after @entity5 testing, and 143 (24  %) had one or more elevated cardiac biomarkers. Among these 143, median age was 73  years (range 44-98 years), and 98 (69  %) were non-Hispanic white. All @entity0 had one or more @entity1 risk factors, and 98 (69  %) had a history of @entity1 . Eighty-six percent of ACI-associated events occurred within 3  days of @entity5 specimen collection date. Seventy @entity0 (49  %) had documented or probable acute @entity4 , 8 (6  %) acute @entity6 , 6 (4  %) @entity10 , and 4 (3  %) @entity8 . Eleven (8  %) had non-cardiac explanations for elevated cardiac biomarkers, and 44 (31  %) had no documented explanation. Sixty-eight (48  %) @entity0 had received @entity5 vaccination during the related @entity5 season. CONCLUSION: Among veterans with laboratory-confirmed @entity2 and cardiac biomarker testing  <=30  days after @entity5 testing, approximately 25  % had evidence of ACI, the majority within 3  days. Approximately half were @entity4 . Our findings emphasize the importance of considering ACI associated with @entity2 among @entity0 at high risk, including this older population with prevalent @entity1 risk factors.

title: Acute XXXX events  <=30  days after laboratory-confirmed @entity7 among U.S. veterans, 2010-2012.

answer: @entity3


abstract: BACKGROUND: @entity3 is a known potential complication of @entity2 . Because U.S. veterans cared for at the U.S. Department of Veterans Affairs are older and have more @entity1 ( @entity1 ) risk factors than the general U.S. population, veterans are at risk for @entity3 of @entity2 . We investigated biomarkers of @entity3 characteristics and associated @entity3 among veterans who received cardiac biomarker testing  <=30  days after laboratory-confirmed @entity7 . METHODS: Laboratory-confirmed @entity5 cases among veterans cared for at U.S. Department of Veterans Affairs' facilities for October 2010-December 2012 were identified using electronic medical records (EMRs). Influenza confirmation was based on respiratory specimen viral culture or antigen or nucleic acid detection. Acute @entity3 (ACI) was defined as an elevated cardiac biomarker (troponin I or @entity9 kinase isoenzyme MB) >99  % of the upper reference limit occurring  <=30  days after @entity5 specimen collection. EMRs were reviewed for demographics, @entity1 history and risk factors, and ACI-associated @entity3 . RESULTS: Among 38,197 @entity0 with @entity5 testing results, 4,469 (12  %) had a positive result; 600 of those @entity0 had cardiac biomarker testing performed  <=30  days after @entity5 testing, and 143 (24  %) had one or more elevated cardiac biomarkers. Among these 143, median age was 73  years (range 44-98 years), and 98 (69  %) were non-Hispanic white. All @entity0 had one or more @entity1 risk factors, and 98 (69  %) had a history of @entity1 . Eighty-six percent of ACI-associated events occurred within 3  days of @entity5 specimen collection date. Seventy @entity0 (49  %) had documented or probable acute @entity4 , 8 (6  %) acute @entity6 , 6 (4  %) @entity10 , and 4 (3  %) @entity8 . Eleven (8  %) had non-cardiac explanations for elevated cardiac biomarkers, and 44 (31  %) had no documented explanation. Sixty-eight (48  %) @entity0 had received @entity5 vaccination during the related @entity5 season. CONCLUSION: Among veterans with laboratory-confirmed @entity2 and cardiac biomarker testing  <=30  days after @entity5 testing, approximately 25  % had evidence of ACI, the majority within 3  days. Approximately half were @entity4 . Our findings emphasize the importance of considering ACI associated with @entity2 among @entity0 at high risk, including this older population with prevalent @entity1 risk factors.

title: Acute @entity3 events  <=30  days after laboratory-confirmed XXXX among U.S. veterans, 2010-2012.

answer: @entity7


abstract: @entity7 -associated @entity6 (EBV-HLH) is a life-threatening complication of @entity4 . MicroRNAs (miRNAs) were small non-coding RNA, and EBV could encode miRNAs that are involved in the progression of @entity1 . However, the profiles of EBV-miRNAs in EBV-HLH were unknown. Here, we aimed to profile the expression of EBV-miRNAs in @entity0 with EBV-HLH by analyzing 44 known EBV-miRNAs, encoded within the BamHI fragment H rightward open reading frame 1 (BHRF1) and the BamHI-A region rightward transcript (BART), in plasma and cellular targets by real-time quantitative PCR. The study included 15 @entity0 with EBV-HLH, 15 @entity0 with @entity5 ( @entity5 ), and 15 healthy controls. @entity2 (+) T cells were found to be the cellular target of @entity4 in EBV-HLH, while @entity3 (+) B cells were infected with EBV in @entity5 . We also found the greater levels of several miRNAs encoded by BART in EBV-HLH, compared to those in @entity5 and healthy controls, whereas the levels of BHRF1 miRNAs were lower than those in @entity5 . The profile and pattern of EBV-miRNAs in EBV-HLH indicated that EBV could display type II latency in EBV-HLH. Importantly, the level of plasma @entity8 -BART16-1 continued decreasing during the whole chemotherapy, suggesting that plasma @entity8 -BART16-1 could be a potential biomarker for monitoring EBV-HLH progression. The pathogenesis of EBV-HLH might be attributed to the abundance of EBV-miRNAs in EBV-HLH. These findings help elucidate the roles of EBV miRNAs in EBV-HLH, enabling the understanding of the basis of this disease and providing clues for its treatment.

title: Profiling of EBV-Encoded microRNAs in EBV-Associated XXXX .

answer: @entity6


abstract: STUDY OBJECTIVE: @entity2 @entity0 have marked circadian variation in disease severity, with @entity5 far worse between midnight and 8 AM than at other times of day. In this study we sought to determine whether circadian variation in @entity1 severity is clinically relevant for purposes of emergency management. DESIGN: Prospective, observational cohort study. SETTING: The emergency department of a large urban university hospital. @entity0 : @entity2 @entity0 16 years and older who presented with the complaint of @entity1 exacerbation. RESULTS: Peak expiratory flow rate (PEFR), respiratory rate, and objective and subjective assessments of @entity3 severity were determined at the time of each @entity0 's presentation to the @entity4 and at the time of disposition decision. Time of symptom onset, duration of symptoms, response to therapy, and final disposition were recorded. Nocturnal presentation and onset were defined as arrival in the @entity4 or onset of symptoms between midnight and 8 AM. We enrolled 188 @entity2 @entity0 in the study; 52 (28%) presented nocturnally. Comparison of @entity2 @entity0 who presented nocturnally and those who presented at other times revealed no differences in initial or final PEFR or respiratory rate, change in PEFR, subjective or objective @entity3 , or rate of hospitalization, although nocturnal @entity0 did have a significantly shorter @entity4 treatment time. Analysis by time of symptom onset also revealed no differences between nocturnally and nonnocturnally presenting subjects in disease severity or outcome, with the exception that those with nocturnal symptom onset had less subjective @entity3 than other @entity2 @entity0 . Repeat analysis with different "nocturnal" time periods did not alter the results. CONCLUSION: In our study group, @entity2 @entity0 who presented nocturnally to the @entity4 did not differ from other @entity2 @entity0 in disease severity and therefore do not appear to represent a unique population for purposes of @entity4 management or disposition decisions.

title: Is circadian variation in XXXX severity relevant in the emergency department?

answer: @entity1


abstract: BACKGROUND: Increasing evidences have indicated that there are gender differences in the prevalence of @entity2 ( @entity1 ), but the mechanism is uncertain. METHODS: A total of 711 subjects aged 35-65  years accepted health examinations both in 1992 and 2007. Since 114 subjects had @entity1 and 7 had @entity3 at baseline, they were excluded from the analysis. Therefore, 590 subjects with complete data (male: 61.5  %) were available and analysed. After the relationship between gender and incident @entity1 at follow-up was tested, these subjects were categorized into four groups according to the baseline resting heart rate(RHR) classified by genders. Trend tests of @entity1 incidences across the four groups of resting heart rate were conducted by Cochran-Armitage tend tests in both @entity0 and @entity0 . Additionally, three logistic regression models were used to estimate the effects of RHR on the new onset of @entity1 by taking RHR as a continuous variable(per 4 beats/min elevation). RESULTS: Gender( @entity0 ) itself was an independent risk factor for incident @entity1 at follow-up(OR   =   2.64, 1.33-5.23, P   =   0.005). The incidences of @entity1 according to the RHR categories showed a statistical linear trend in @entity0 (P for trend   =   0.018) rather than in @entity0 (P for trend   =   0.194). The ORs[95  % confidence intervals(CIs)] of @entity1 for each 4  bpm elevation in RHR was 1.18(1.03-1.36)(P   =   0.020) in a univariate model, 1.20 (1.04-1.38) (P   =   0.011) adjusted for age and health related behaviors only and 1.23(1.06-1.43)(P   =   0.007) adjusted for age, health related behaviors and pre-existing components of @entity1 in the baseline in @entity0 . Otherwise, RHR did not have any significant associations with incident @entity1 in @entity0 neither in a univariate model nor in multivariate models. CONCLUSIONS: In this study, elevated RHR is correlated with the development of @entity1 in @entity0 rather than in @entity0 .

title: Elevated resting heart rate predisposes XXXX in @entity0 rather than in @entity0 : a 15-year prospective study.

answer: @entity2


abstract: BACKGROUND: Increasing evidences have indicated that there are gender differences in the prevalence of @entity2 ( @entity1 ), but the mechanism is uncertain. METHODS: A total of 711 subjects aged 35-65  years accepted health examinations both in 1992 and 2007. Since 114 subjects had @entity1 and 7 had @entity3 at baseline, they were excluded from the analysis. Therefore, 590 subjects with complete data (male: 61.5  %) were available and analysed. After the relationship between gender and incident @entity1 at follow-up was tested, these subjects were categorized into four groups according to the baseline resting heart rate(RHR) classified by genders. Trend tests of @entity1 incidences across the four groups of resting heart rate were conducted by Cochran-Armitage tend tests in both @entity0 and @entity0 . Additionally, three logistic regression models were used to estimate the effects of RHR on the new onset of @entity1 by taking RHR as a continuous variable(per 4 beats/min elevation). RESULTS: Gender( @entity0 ) itself was an independent risk factor for incident @entity1 at follow-up(OR   =   2.64, 1.33-5.23, P   =   0.005). The incidences of @entity1 according to the RHR categories showed a statistical linear trend in @entity0 (P for trend   =   0.018) rather than in @entity0 (P for trend   =   0.194). The ORs[95  % confidence intervals(CIs)] of @entity1 for each 4  bpm elevation in RHR was 1.18(1.03-1.36)(P   =   0.020) in a univariate model, 1.20 (1.04-1.38) (P   =   0.011) adjusted for age and health related behaviors only and 1.23(1.06-1.43)(P   =   0.007) adjusted for age, health related behaviors and pre-existing components of @entity1 in the baseline in @entity0 . Otherwise, RHR did not have any significant associations with incident @entity1 in @entity0 neither in a univariate model nor in multivariate models. CONCLUSIONS: In this study, elevated RHR is correlated with the development of @entity1 in @entity0 rather than in @entity0 .

title: Elevated resting heart rate predisposes @entity2 in XXXX rather than in @entity0 : a 15-year prospective study.

answer: @entity0


abstract: BACKGROUND: Increasing evidences have indicated that there are gender differences in the prevalence of @entity2 ( @entity1 ), but the mechanism is uncertain. METHODS: A total of 711 subjects aged 35-65  years accepted health examinations both in 1992 and 2007. Since 114 subjects had @entity1 and 7 had @entity3 at baseline, they were excluded from the analysis. Therefore, 590 subjects with complete data (male: 61.5  %) were available and analysed. After the relationship between gender and incident @entity1 at follow-up was tested, these subjects were categorized into four groups according to the baseline resting heart rate(RHR) classified by genders. Trend tests of @entity1 incidences across the four groups of resting heart rate were conducted by Cochran-Armitage tend tests in both @entity0 and @entity0 . Additionally, three logistic regression models were used to estimate the effects of RHR on the new onset of @entity1 by taking RHR as a continuous variable(per 4 beats/min elevation). RESULTS: Gender( @entity0 ) itself was an independent risk factor for incident @entity1 at follow-up(OR   =   2.64, 1.33-5.23, P   =   0.005). The incidences of @entity1 according to the RHR categories showed a statistical linear trend in @entity0 (P for trend   =   0.018) rather than in @entity0 (P for trend   =   0.194). The ORs[95  % confidence intervals(CIs)] of @entity1 for each 4  bpm elevation in RHR was 1.18(1.03-1.36)(P   =   0.020) in a univariate model, 1.20 (1.04-1.38) (P   =   0.011) adjusted for age and health related behaviors only and 1.23(1.06-1.43)(P   =   0.007) adjusted for age, health related behaviors and pre-existing components of @entity1 in the baseline in @entity0 . Otherwise, RHR did not have any significant associations with incident @entity1 in @entity0 neither in a univariate model nor in multivariate models. CONCLUSIONS: In this study, elevated RHR is correlated with the development of @entity1 in @entity0 rather than in @entity0 .

title: Elevated resting heart rate predisposes @entity2 in @entity0 rather than in XXXX : a 15-year prospective study.

answer: @entity0


abstract: BACKGROUND: @entity1 (PVAs) are rare, and the pathogenesis is not fully understood. The optimum management of these @entity0 is unknown. METHODS: Consecutive @entity0 with @entity5 were identified over an 18-year period (1992-2010). A retrospective review was conducted. Clinical presentation, modality of diagnosis, surgical treatment, 30-day morbidity and mortality, and follow-up are reported. RESULTS: Four @entity0 were identified who underwent surgical management of an extrahepatic @entity5 . Operative technique using left renal vein, femoral vein panel graft, @entity4 (ePTFE) graft, and segmental @entity1 wall resected with aneurysmorrhaphy is described. Early complications occurred in 1 @entity0 with an ePTFE graft. The @entity0 returned to the operating room for @entity2 . In addition, the same @entity0 had a late graft @entity3 6 years postoperatively when the anticoagulation was discontinued for pregnancy. The remainder of the @entity0 recovered without complication, and their repairs are still patent with a mean follow-up of 78  months (17-144  months). There were no mortalities in the series. CONCLUSIONS: Operative intervention for portomesenteric @entity1 can be done safely in select @entity0 and should be considered in those with symptoms, rapid growth, mural @entity3 , or @entity1 >= 4  cm in diameter. Repair with an autogenous interposition graft affords good long-term patency. Aneurysmorrhaphy may be performed if the remaining venous wall is of good quality.

title: Operative Interventions for Extrahepatic XXXX and Long-Term Outcomes.

answer: @entity1


abstract: BACKGROUND: @entity2 are rarely witnessed by physicians, and the diagnosis is usually made on the basis of the history. Tongue biting is classically considered to favor a diagnosis of @entity1 . The usefulness of tongue biting in the differential diagnosis of @entity2 was evaluated. METHODS: A prospective study of the presence of oral lacerations in 106 consecutive @entity0 admitted to our Epilepsy Monitoring Unit and a retrospective study of a population of 45 @entity0 with @entity4 were performed. The relationship between tongue biting and diagnosis ( @entity1 vs nonepileptic events) was analyzed. RESULTS: Of the 106 monitored @entity0 , 63 had episodes characterized by bilateral motor activity, @entity3 , or both; 34 @entity0 had @entity1 , while 29 @entity0 had exclusively nonepileptic episodes. Eight @entity0 suffered an oral laceration; all involved the side of the tongue, and all had documented @entity1 . Of the 45 @entity0 with @entity4 , in only one was the tongue lacerated, and this was at the tip. Tongue biting had a sensitivity of 24% and a specificity of 99% for the diagnosis of generalized @entity2 . @entity5 was 100% specific to grand @entity2 . CONCLUSION: Tongue biting, particularly if it is lateral, is highly specific to generalized @entity2 .

title: @entity5 biting in the diagnosis of XXXX .

answer: @entity2


abstract: BACKGROUND: @entity2 are rarely witnessed by physicians, and the diagnosis is usually made on the basis of the history. Tongue biting is classically considered to favor a diagnosis of @entity1 . The usefulness of tongue biting in the differential diagnosis of @entity2 was evaluated. METHODS: A prospective study of the presence of oral lacerations in 106 consecutive @entity0 admitted to our Epilepsy Monitoring Unit and a retrospective study of a population of 45 @entity0 with @entity4 were performed. The relationship between tongue biting and diagnosis ( @entity1 vs nonepileptic events) was analyzed. RESULTS: Of the 106 monitored @entity0 , 63 had episodes characterized by bilateral motor activity, @entity3 , or both; 34 @entity0 had @entity1 , while 29 @entity0 had exclusively nonepileptic episodes. Eight @entity0 suffered an oral laceration; all involved the side of the tongue, and all had documented @entity1 . Of the 45 @entity0 with @entity4 , in only one was the tongue lacerated, and this was at the tip. Tongue biting had a sensitivity of 24% and a specificity of 99% for the diagnosis of generalized @entity2 . @entity5 was 100% specific to grand @entity2 . CONCLUSION: Tongue biting, particularly if it is lateral, is highly specific to generalized @entity2 .

title: XXXX biting in the diagnosis of @entity2 .

answer: @entity5


abstract: INTRODUCTION: Upper intestinal leaks and perforations are associated with high morbidity and mortality rates. Despite the growing experience using endoscopically placed stents, the treatment of these leaks and perforations remain a challenge. Endoluminal vacuum (E-Vac) therapy is a novel treatment that has been successfully used in Germany to treat upper @entity2 and perforations. There currently are no reports on its use in the USA. METHODS: E-Vac therapy was used to treat 11 @entity0 with upper @entity2 and perforations from September 2013 to September 2014. Five @entity0 with leaks following sleeve gastrectomy were excluded from this study. A total of six @entity0 were treated with E-Vac therapy; these included: (n  =  2) iatrogenic esophageal perforations, (n  =  1) iatrogenic esophageal and gastric perforations, (n  =  1) iatrogenic @entity3 , (n  =  1) gastric staple line leak following a surgical repair of a traumatic @entity3 , and (n  =  1) esophageal perforation due to an invasive @entity4 . Four @entity0 had failed an initial surgical repair prior to starting E-Vac therapy. RESULTS: All six @entity0 (100  %) had complete closure of their perforation or leak after an average of 35.8  days of E-Vac therapy requiring 7.2 different E-Vac changes. No @entity1 occurred in the 30  days following E-Vac therapy. One @entity0 died following complete closure of his perforation and transfer to an acute care facility due to an unrelated complication. There were no complications directly related to the use of E-Vac therapy. Only one @entity0 had any symptoms of @entity5 . This @entity0 had severe @entity5 from an esophagogastric anastomotic stricture prior to her iatrogenic perforations. Following E-Vac therapy, her @entity5 had actually improved and she could now tolerate a soft diet. CONCLUSIONS: E-Vac therapy is a promising new method in the treatment of upper @entity2 and perforations. Current successes need to be validated through future prospective controlled studies.

title: The use of endoluminal vacuum (E-Vac) therapy in the management of upper XXXX and perforations.

answer: @entity2


abstract: INTRODUCTION: We herein describe a rare case of a sclerosing @entity3 without IgG4-related disease. This case was clearly excluded from IgG4-related disease, because this patient's serum IgG4 level was not elevated. Specifically, this patient's serum IgG4 level was 7.9mg/dl (4.8-105). PRESENTATION OF CASE: A 61-year-old Japanese female presented at our hospital due to an abnormal chest X-ray that showed a growing shadow in the mediastinum. Chest computed tomography (CT) showed an 80*75*75mm @entity1 , which located in the anterior mediastinum. This large @entity1 surrounded the thoracic aorta, left brachiocephalic vein and superior vena cava. It was difficult to obtain a definitive diagnosis. We tried to perform three biopsies, and eventually performed a partial resection of the @entity1 . DISCUSSION: This case did not fit the criteria for IgG4-related disease, and it was therefore unclear whether @entity2 therapy should be used for this case. We will continue to carefully follow up this @entity0 's residual lesion, and there have been no changes in the lesion at present. CONCLUSION: Sclerosing @entity3 and IgG4-related disease should be included in the differential diagnosis of @entity0 presenting with a @entity1 . However, sclerosing @entity3 is difficult to diagnose, and it is important to obtain a sufficient amount of tissue to ensure an accurate diagnosis.

title: Sclerosing XXXX of unknown origin: Report of a case.

answer: @entity3


abstract: UNASSIGNED: There are few effective treatments for recurrent @entity1 ( @entity1 ). We present a @entity0 with recurrent @entity1 who achieved a prolonged response to treatment with @entity5 , an irreversible @entity2 family blocker, plus @entity4 . A 58-year-old female @entity0 was diagnosed with multifocal primary @entity1 . After surgical resection, first-line therapy comprised radiotherapy and @entity4 . Following disease progression after 3 @entity4 cycles, the @entity0 entered a phase I/II clinical trial of @entity5 (20-40 mg daily for 28 days) plus @entity4 (50 mg/m2 every 21/28 days). Next-generation sequencing analysis of the @entity3 specimen was performed. At the last assessment, 63 treatment cycles had been completed and the @entity0 had survived for ~5 years since recurrence. Significant disease regression was observed after 5 cycles and was maintained during long-term follow-up. Adverse events were consistent with the known tolerability profile of @entity5 and were managed by treatment interruption/dose reduction. The @entity0 had several @entity2 ( @entity2 ) aberrations, including gene amplification and EGFRvIII positivity. Three somatic mutations were identified, including an unprecedented extracellular-domain substitution ( @entity6 ). The @entity0 has survived ~6-fold longer than normally expected in @entity0 with recurrent @entity1 . The complex @entity2 genotype may underlie sustained response to @entity5 plus @entity4 .

title: XXXX , an irreversible @entity2 family blocker, with protracted @entity4 in recurrent @entity1 : a case report.

answer: @entity5