abstract: @entity1 (SNC) in @entity0 were produced by electrolytic coagulation or by an injection of @entity10 . Two to 5 weeks later, after being preselected for @entity14 -induced @entity3 behavior, the animals were administered narcotic agonists or antagonists and their circling behavior was observed. @entity5 , @entity2 , @entity16 , @entity17 or @entity15 induced @entity3 movements; both @entity6 and @entity13 were without effect. Ipsilateral circling was also observed in @entity0 with unilateral electrolytic lesions after administration of agents that are thought to enhance central dopaminergic activities: @entity9 , @entity11 and @entity12 . In @entity0 with unilateral electrolytic or @entity10 SNC lesions that were rendered highly @entity5 -dependent by multiple- @entity5 pellet implantation, contralateral (C) circling behavior was observed within 1 to 2 minutes after a @entity6 challenge; the onset and duration of C circling behavior coincided with the initial appearance and duration of precipitated- @entity5 withdrawal signs. C circling was also observed after administration of putative @entity4 receptor blockers, @entity8 and @entity7 in @entity0 with either unilateral electrolytic or @entity10 SNC lesions. @entity5 pretreatment diminished both the C circling intensity and the appearance of withdrawal signs observed after a @entity6 challenge in @entity5 -dependent, SNC-lesioned @entity0 . The @entity6 -precipitated withdrawal in unilaterally lesioned @entity5 -dependent @entity0 was accompanied by a 20% elevation of neostriatal @entity4 in the intact side. In contrast to the effects of a chronic @entity1 in decreasing neostriatal @entity4 , a 77% increase was observed in the lesioned side 30 minutes after electrolytic coagulation. Thus, narcotic agonists and partial agonists may enhance central dopaminergic activities and @entity6 -precipitated withdrawal may involve a diminution in central dopaminergic activities of the nigroneostriatal pathway.

title: Circling behavior after narcotic drugs and during @entity6 -precipitated abstinence in XXXX with unilateral nigral lesions.

answer: @entity0


abstract: Suicide and decompensation of @entity5 peak in spring and, to a lesser extent, in fall. Several recent studies reported that suicide and decompensation peaks coincided with spring and fall aeroallergen peaks. @entity1 occur as the result of a complex biochemical cascade initiated by IgE antibodies (sensitization) and allergens (triggers). Animal models have shown molecular/neurochemical changes in the brain, as well as relevant behavioral changes associated with this IgE-mediated biochemical cascade. These factors suggest that @entity4 could precipitate suicidality and mood instability. In the current study, we compared the prior suicide attempt and history of decompensation of @entity6 in allergen sensitive vs nonsensitive @entity0 . Further, we compared the ratio of events (attempts and decompensations) during the @entity4 season to events occurring during the rest of the year. @entity0 with @entity3 or @entity2 (n=80) were studied. There were no statistical differences in any measurement performed between the allergen sensitive and nonsensitive @entity0 . These negative results are not consistent with recent epidemiological studies supporting a predictive association between @entity4 and categorical measures of suicidality (ideation, attempts, and completion). Clinical samples are likely not adequate to study less than strong predictive associations with suicide and suicide risk factors.

title: Allergen Specific IgE, Number and Timing of Past Suicide Attempts, and Instability in @entity0 with Recurrent XXXX .

answer: @entity6


abstract: Suicide and decompensation of @entity5 peak in spring and, to a lesser extent, in fall. Several recent studies reported that suicide and decompensation peaks coincided with spring and fall aeroallergen peaks. @entity1 occur as the result of a complex biochemical cascade initiated by IgE antibodies (sensitization) and allergens (triggers). Animal models have shown molecular/neurochemical changes in the brain, as well as relevant behavioral changes associated with this IgE-mediated biochemical cascade. These factors suggest that @entity4 could precipitate suicidality and mood instability. In the current study, we compared the prior suicide attempt and history of decompensation of @entity6 in allergen sensitive vs nonsensitive @entity0 . Further, we compared the ratio of events (attempts and decompensations) during the @entity4 season to events occurring during the rest of the year. @entity0 with @entity3 or @entity2 (n=80) were studied. There were no statistical differences in any measurement performed between the allergen sensitive and nonsensitive @entity0 . These negative results are not consistent with recent epidemiological studies supporting a predictive association between @entity4 and categorical measures of suicidality (ideation, attempts, and completion). Clinical samples are likely not adequate to study less than strong predictive associations with suicide and suicide risk factors.

title: Allergen Specific IgE, Number and Timing of Past Suicide Attempts, and Instability in XXXX with Recurrent @entity6 .

answer: @entity0


abstract: BACKGROUND: @entity1 represent an increasing burden for health care systems. Ongoing research efforts provide regularly new scientific evidence on how optimize current medical care. In regard to @entity3 , as for other health problems, optimal management of these conditions has been summarized in recent consensus guidelines but implementation of these recommendations is still poor. Not only are the key messages of such guidelines often unknown to the practitioner and the @entity0 but even when it is, they are often insufficiently integrated into current care, often related to behavioral, organizational and communication barriers. METHODS: Literature review on the topic of Clinical Practice Guidelines implementation and reference to recent projects aimed at improving management of @entity2 in the province of Quebec and elsewhere, as models for such implementation process. RESULTS: The basic principles of an effective translation of current knowledge into day-to-day care are known, but healthcare delivery structures, practice tools and resources, and regional/local leadership should be available to make it happen. Ideally, implementation requires a multidisciplinary effort of care providers, specialists, general practitioners, allied health professionals, @entity0 and their family. The general public, health administrators and policy makers should also be aware of the consequences of poor management of these diseases and be supportive of the proposed initiatives. Finally, these last should be adequately evaluated to ensure their effectiveness and determine if they should be improved. Recently projects performed in Quebec have proposed disease management models to identify @entity2 care gaps and improve translation of current Guidelines into day-to-day care. CONCLUSIONS: Although the @entity0 and socio-economical burden of @entity1 is still increasing, their current management is still often deficient. In the recent decades, Practice Guidelines have been developed to guide Practitioners towards optimal care, but implementation of these Guides is still poor. Recent Canadian and International initiatives have proposed valid models to help address current care gaps.

title: Improving knowledge transfer on chronic XXXX : a Canadian perspective. How to translate recent advances in @entity3 into day-to-day care.

answer: @entity3


abstract: BACKGROUND: @entity1 represent an increasing burden for health care systems. Ongoing research efforts provide regularly new scientific evidence on how optimize current medical care. In regard to @entity3 , as for other health problems, optimal management of these conditions has been summarized in recent consensus guidelines but implementation of these recommendations is still poor. Not only are the key messages of such guidelines often unknown to the practitioner and the @entity0 but even when it is, they are often insufficiently integrated into current care, often related to behavioral, organizational and communication barriers. METHODS: Literature review on the topic of Clinical Practice Guidelines implementation and reference to recent projects aimed at improving management of @entity2 in the province of Quebec and elsewhere, as models for such implementation process. RESULTS: The basic principles of an effective translation of current knowledge into day-to-day care are known, but healthcare delivery structures, practice tools and resources, and regional/local leadership should be available to make it happen. Ideally, implementation requires a multidisciplinary effort of care providers, specialists, general practitioners, allied health professionals, @entity0 and their family. The general public, health administrators and policy makers should also be aware of the consequences of poor management of these diseases and be supportive of the proposed initiatives. Finally, these last should be adequately evaluated to ensure their effectiveness and determine if they should be improved. Recently projects performed in Quebec have proposed disease management models to identify @entity2 care gaps and improve translation of current Guidelines into day-to-day care. CONCLUSIONS: Although the @entity0 and socio-economical burden of @entity1 is still increasing, their current management is still often deficient. In the recent decades, Practice Guidelines have been developed to guide Practitioners towards optimal care, but implementation of these Guides is still poor. Recent Canadian and International initiatives have proposed valid models to help address current care gaps.

title: Improving knowledge transfer on chronic @entity3 : a Canadian perspective. How to translate recent advances in XXXX into day-to-day care.

answer: @entity3


abstract: In a recent study, the vasodilating drugs @entity6 , @entity9 , @entity10 , and @entity8 induced @entity3 in @entity1 , when given on day 16 of pregnancy. Histologically, the changes were characterized by disturbed chondrogenesis. In order to elucidate mechanisms behind the defects, the fetal concentration of @entity10 was measured, and the fetal limb plates were examined histologically, at 0, 2, 4, 8, 12, and 24 hours after single oral administration of @entity10 (12 mumol/kg) on day 16 in pregnant @entity1 . The effects of @entity6 , @entity9 , and @entity10 were also investigated in an in vitro system, in which @entity7 embryonic mesenchymal limb bud cells differentiated into chondrocytes. In this system, no inhibition of chondrogenesis was observed below concentrations 3 x 10(5) M. At this concentration, unspecific @entity2 was found. The highest fetal concentrations of @entity10 were more than 500 times lower than what was required for in vitro @entity2 . Histologically, the digital areas of the limb plates showed extensive @entity0 and dilatation of marginal sinus within 2 hours. After 8 hours, @entity4 of the thin-walled vessels occurred with @entity5 . Finally, small necroses and blisters were observed. Similar early changes have been reported in experiments where @entity3 were induced by clamping uterine vessels. This study thus indicates that the @entity3 after administration of high doses of vasodilators are secondary to pharmacological action (associated with a significant reduction in the uteroplacental blood flow), and not a direct effect on fetal chondrogenesis.

title: Histological and in vitro studies supporting decreased uteroplacental blood flow as explanation for XXXX after administration of vasodilators.

answer: @entity3


abstract: BACKGROUND: Operative techniques for the management of juvenile @entity2 of the knee include drilling, internal fixation, fragment removal, and chondral resurfacing. PURPOSE: To evaluate the functional and radiographic outcome of internal fixation of juvenile @entity2 of the knee. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: The study design was a retrospective case series. Twenty-six knees in 24 skeletally immature @entity0 underwent internal fixation of @entity2 . Mean follow-up was 4.25 years (range, 2-14.75 years). Mean @entity0 age was 14.7 years (range, 11-16 years). There were 13 @entity0 and 11 @entity0 . Lesions were graded per the Ewing and Voto classification, with 9 stage II lesions (fissured), 11 @entity1 (partially attached), and 6 stage IV lesions (detached). Methods of internal fixation included variable pitch screws (n = 11), bioabsorbable tacks (n = 10), partially threaded cannulated screws (n = 3), and bioabsorbable pins (n = 3). Mean follow-up was 4.25 years (range, 2.0-14.75 years). RESULTS: Healing occurred in 22 of 26 lesions (healing rate, 84.6%). There was no significant difference in healing rate for lesion location, fixation method, or lesion grade. In fact, all 6 stage IV (detached) lesions healed. The mean postoperative Lysholm score was 85.8, mean postoperative International Knee Documentation Committee score was 82.6, and mean postoperative Tegner activity level was 7.4. Mean time to healing was 6 months. Eight @entity0 underwent additional procedures: 4 for nonunion, 1 for @entity3 , and 3 for elective screw removal. CONCLUSION: Given the relatively high healing rate, good functional outcome, and low complication rate, the authors advocate internal fixation of unstable juvenile @entity2 of the knee, even for detached lesions and in @entity0 with a history of surgery for the @entity2 .

title: Internal fixation of juvenile XXXX of the knee.

answer: @entity2


abstract: In the therapy of the chronic peripheral @entity1 , angioplasty is rarely used to treat the infra-renal @entity2 , whereas the @entity3 and the short occlusion of the iliac artery is a classical indication. Primarily, stenoses and occlusions of the iliac artery should be treated with balloon angioplasty exclusively. Only secondarily, when the result of angioplasty was insufficient, e.g. remaining @entity3 or dissection, stent implantation is appropriate. Angioplasty is most frequently applied in the obliteration of the femoro-popliteal artery. It can be stated that early- and long-term results are the better, the shorter the occlusion is. Stent implantation in the femoro-popliteal artery should be avoided because of poor results. Only with the intention of limb salvage, when there is no opportunity for surgical treatment, a stent implantation should be considered. In case of recurrent stenoses after stent implantation, angioplasty can be reapplied with great success. The indication for any vascular intervention should be a decision of both, the interventional radiologist and the vascular surgeon, because both kinds of treatment are palliative and not causal. It is the task of the angiologist to do clinical diagnostics and the after-treatment. Quality monitoring is indispensable. It consists of documentation of pre-angioplasty diagnostics and should be able to prove the correct indication for the intervention. The result of the intervention should also be documented by angiography and functional tests. Regular control of the @entity0 after the intervention is necessary for the early recognition of recurrent stenoses.

title: [Possibilities and limits of interventional therapy in chronic peripheral XXXX ].

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity3 ) is a severe side effect of the prophylaxis of @entity8 with unfractionated heparin. The aim of the present study is to gain more information on the incidence of @entity3 during prophylaxis of @entity8 with low-molecular-weight heparin in elective hip surgery. METHODS: 586 consecutive @entity0 were included into the prospective study, who were admitted to hospital for elective hip replacement. The incidence of @entity3 , clinically manifest @entity8 and of the heparin-induced IgG antibodies were analysed during prophylaxis with low molecular-weight heparin. @entity0 received once daily subcutaneously low molecular-weight heparin for a mean of 28 days postoperatively. Platelet counts and clinical examinations for the presence of @entity8 were done at days 0, 2, 7 (+/- 1) and 12 (+/- 2). Heparin-induced IgG antibodies were determined before and after a 12 (+/- 2) days prophylaxis with low molecular-weight heparin in 265 of 586 @entity0 randomly. @entity0 were reexamined for @entity5 complications after 3 and 6 months. The clinical suspicion of @entity5 complication was documented objectively. RESULTS: None of the @entity0 developed a decrease of platelets of < 50% of the initial value. Ten of 265 @entity0 had elevated IgG antibodies against heparin/platelet factor 4 before prophylaxis (3.8%). After the 12 (+/- 2) days prophylaxis 13 of 265 @entity0 had elevated IgG antibodies (4.9%). C14 @entity2 assay was positive in 0 of 10 @entity0 before treatment and in 3 of 19 @entity0 at day 12 (+/- 2). Ten @entity0 developed @entity8 postoperatively (8 x @entity6 , 2 x @entity7 , no fatal @entity4 ). Only 1/19 @entity0 with elevated antiheparin IgG titres developed @entity8 . The C14 @entity2 assay was negative in this @entity0 . Two @entity0 died in the postoperative phase due to underlying @entity1 . CONCLUSIONS: In @entity0 with elective hip replacement prophylaxis of @entity8 with low molecular-weight heparin was associated with a very low incidence of @entity3 , and hence screening for @entity3 antibodies is not required.

title: [ @entity3 after elective hip joint replacement with postoperative prevention of XXXX with low-molecular-weight heparin].

answer: @entity5


abstract: BACKGROUND: @entity3 ( @entity3 ) is a severe side effect of the prophylaxis of @entity8 with unfractionated heparin. The aim of the present study is to gain more information on the incidence of @entity3 during prophylaxis of @entity8 with low-molecular-weight heparin in elective hip surgery. METHODS: 586 consecutive @entity0 were included into the prospective study, who were admitted to hospital for elective hip replacement. The incidence of @entity3 , clinically manifest @entity8 and of the heparin-induced IgG antibodies were analysed during prophylaxis with low molecular-weight heparin. @entity0 received once daily subcutaneously low molecular-weight heparin for a mean of 28 days postoperatively. Platelet counts and clinical examinations for the presence of @entity8 were done at days 0, 2, 7 (+/- 1) and 12 (+/- 2). Heparin-induced IgG antibodies were determined before and after a 12 (+/- 2) days prophylaxis with low molecular-weight heparin in 265 of 586 @entity0 randomly. @entity0 were reexamined for @entity5 complications after 3 and 6 months. The clinical suspicion of @entity5 complication was documented objectively. RESULTS: None of the @entity0 developed a decrease of platelets of < 50% of the initial value. Ten of 265 @entity0 had elevated IgG antibodies against heparin/platelet factor 4 before prophylaxis (3.8%). After the 12 (+/- 2) days prophylaxis 13 of 265 @entity0 had elevated IgG antibodies (4.9%). C14 @entity2 assay was positive in 0 of 10 @entity0 before treatment and in 3 of 19 @entity0 at day 12 (+/- 2). Ten @entity0 developed @entity8 postoperatively (8 x @entity6 , 2 x @entity7 , no fatal @entity4 ). Only 1/19 @entity0 with elevated antiheparin IgG titres developed @entity8 . The C14 @entity2 assay was negative in this @entity0 . Two @entity0 died in the postoperative phase due to underlying @entity1 . CONCLUSIONS: In @entity0 with elective hip replacement prophylaxis of @entity8 with low molecular-weight heparin was associated with a very low incidence of @entity3 , and hence screening for @entity3 antibodies is not required.

title: [ XXXX after elective hip joint replacement with postoperative prevention of @entity5 with low-molecular-weight heparin].

answer: @entity3


abstract: Computed tomography (CT)-guided biopsy of the spine is considered a safe, accurate, and relatively inexpensive examination technique. Our purpose was to determine the diagnostic accuracy of CT-guided biopsies exclusively for @entity2 . A retrospective study was performed from a consecutive series of 72 @entity0 with confirmed @entity2 with 46 CT-guided biopsies performed in 40 @entity0 . Biopsy specimens were sent for bacteriologic and cytologic analysis. An adequate specimen for microbiologic examination was not obtained in one case and not enough sample for additional pathologic examination in 17 cases. The mean age of @entity0 was 58 years, with a range of 1-88 years, including 24 @entity0 and 16 @entity0 . The level of spinal biopsy was thoracic in 18 (40%) and lumbar in 28 (60%). The analysis revealed the infection agent in 20 cases (43% sensitivity). Diagnostic rates obtained in @entity0 with previous antibiotic treatment were significantly lower (23% vs. 60%, p = 0.013). Computed tomography-guided fine-needle aspiration biopsy is an important tool in the diagnostic evaluation of @entity2 . However, this technique yields a lower diagnostic rate than previously reported biopsy of neoplastic @entity1 , especially if performed in @entity0 with previous antibiotic treatment.

title: CT-guided fine-needle aspiration in XXXX : true usefulness of a common practice.

answer: @entity2


abstract: The management of anaesthesia in @entity0 suffering @entity2 has to be selected individually. There is a high rate of caesarean sections in @entity0 with @entity2 . Intubation anaesthesia or regional anaesthesia are commonly used methods and can be considered comparable and equally useful. In our opinion, the application of regional anaesthesia should be preferred, if the initial criteria, such as normal neurologic status and @entity1 , are fulfilled. We believe in a considerable reduction of vital risks when using regional anaesthesia. Our aim was to figure out the risk-factors of @entity2 and preterm maturity regarding anaesthesia management. @entity2 is a severe illness in pregnancy with a frequency of 5-10%. In 1997, we experienced 73 @entity0 with praeeclampsia according to the definition of ISSPH. Mode of delivery was conventional in 10 @entity0 , 2 @entity0 had a vacuum extraction and 61 @entity0 needed a caesarean section. The rate of epidural anesthesia for delivery was 51%. We used epidural anaesthesia in 6 spontaneous deliveries, in 2 vacuum extractions and in 30 caesarean sections. There were no problems with epidural anaesthesia and the outcome of mother and @entity0 was also considered to be excellent. We suggest to use regional anesthesia techniques whenever possible.

title: [ XXXX and anesthesia].

answer: @entity2


abstract: BACKGROUND: Decreased callosal size and anisotropy have been described in @entity1 @entity0 but their longitudinal progression remains poorly understood. METHODS: We performed diffusion-tensor and structural magnetic resonance imaging at baseline and at follow-up four years later in 49 chronic @entity1 @entity0 and 16 healthy comparison subjects. @entity1 @entity0 were subdivided into good-outcome (n=23) and poor-outcome (n=26) groups. Baseline-to-follow-up changes in size, shape, position and fractional anisotropy of the corpus callosum, divided into five sagittal sections and five rostro-caudal segments, were assessed. RESULTS: At baseline scan and in comparison to healthy subjects, @entity1 @entity0 displayed 1) smaller callosal size, 2) lower average anisotropy in all sagittal sections except the midline, and 3) more dorsal average coordinate position. During the four years after the baseline scan, @entity0 with @entity1 exhibited a more pronounced decline in absolute size of the corpus callosum than healthy comparison subjects. As compared with the good-outcome group, the corpus callosum in poor-outcome @entity0 at baseline was of smaller size and lower average anisotropy, more elongated and posteriorly positioned. During the follow-up interval, poor-outcome @entity0 displayed a more pronounced decline in size but less pronounced decline in anisotropy of the corpus callosum than @entity0 with good outcomes. CONCLUSIONS: Differences in callosal size between @entity1 @entity0 and healthy subjects seen at baseline continue to widen in the chronic phase of the illness, especially in @entity0 with poor functional outcome. Baseline differences in callosal anisotropy among @entity0 with different outcomes, however, diminish over time.

title: A longitudinal study of the corpus callosum in chronic XXXX .

answer: @entity1


abstract: HISTORY AND ADMISSION FINDINGS: A 38-year-old @entity0 was admitted for increasing @entity10 , @entity5 and emesis during the preceding year. Clinically he was in @entity7 NYHA stage III. He had not been on any regular medication and had no other medical complaints. Physical examination revealed a pulse of 100/min., @entity6 (100/60 mmHg) and @entity11 . Bilateral pulmonary rales were noted on auscultation. A slight @entity1 of both lower legs was noted. INVESTIGATIONS: A 12-lead electrocardiogram showed complete @entity8 with a QRS duration of 160 ms. Chest x-ray revealed @entity9 with @entity4 . Transthoracic echocardiography demonstrated reduced left ventricular function with an ejection fraction of 10-15%. Left heart catheterization excluded @entity3 and confirmed the decreased left ventricular function. TREATMENT AND COURSE: Medical treatment for @entity7 secondary to dilated @entity2 was initiated without significant improvement in clinical status. Cardiac resynchronization therapy (CRT) was therefore performed with implantation of a biventricular pacer with defibrillator (CRT-D) and a fluid status monitoring system (OptiVol). Subsequently the @entity0 was able to increase his physical activity to NYHA class II and was followed in our outpatient clinic. Since initial treatment the @entity0 has been seen twice for clinical signs of @entity12 . Both times the fluid monitoring system of the CRT-D gave an alarm signal early enough to allow cardiac re-compensation by expanding the current medication. Both times hospital admission was avoided. CONCLUSIONS: Cardiac resynchronization therapy has been established as an adjunct to optimal pharmacological therapy in eligible @entity0 with severe @entity7 . A fluid status monitoring system integrated into the device measures intrathoracic impedance, allowing @entity0 to be alerted before the onset of symptoms of fluid overload. Thus, treatment can be adjusted and hospitalization is avoidable.

title: [Early warning system for pulmonary fluid status monitoring in terminal XXXX ].

answer: @entity7


abstract: CASE HISTORY: A 17-year-old male presented in an agitated, deranged state with rapidly increasing swelling of the neck. Except for regular abuse of @entity5 there was no medical history of note. He had a @entity10 (130 bpm), a slow pupillary reflex, @entity7 and @entity11 around the neck and shoulders. INVESTIGATIONS AND DIAGNOSIS: Laboratory tests showed elevated inflammatory markers. The chest X-ray demonstrated a bilateral pneumothorax and large @entity11 . Subsequent computed tomography of neck and thorax showed an extensive @entity12 and the described @entity11 . There was no evidence of a ruptured @entity4 or esophageal perforation. The underlying cause was presumed to have been a Valsalva maneuver during marijuana smoking. TREATMENT AND COURSE: As the pneumothorax was completely reabsorbed, no chest drains were inserted and the @entity0 was transferred to our toxicological intensive care unit. Recurring drug-induced @entity2 had to be treated with repeated doses of @entity8 . The @entity9 was slowly reabsorbed without any further complication. The @entity0 was transferred back to a @entity1 ward after five days. CONCLUSION: Although @entity5 is thought to be one of the "safe" drugs, its abuse can have life-threatening effects. One complication is the occurrence of a pneumothorax after a Valsalva maneuver. As the rate of @entity5 has been increasing during the last few years, the risk of life-threatening complications should be mentioned in relevant publications and as part of drug education. @entity0 presenting with @entity6 should always be carefully questioned about possible @entity3 .

title: ["Usual" XXXX producing an unusual incident].

answer: @entity5


abstract: @entity1 is a devastating disease. For transmission to occur, Plasmodium, the causative agent of @entity1 , must complete a complex developmental cycle in its mosquito vector. Thus, the mosquito is a potential target for disease control. Plasmodium ookinetes, which develop within the mosquito midgut, must first cross the midgut's peritrophic matrix (PM), a thick extracellular sheath that completely surrounds the blood meal. The PM poses a partial, natural barrier against parasite invasion of the midgut and it is speculated that modifications to the PM may lead to a complete barrier to @entity0 . However, such strategies require thorough characterization of the structure of the PM. Here, we describe for the first time, the complete PM proteome of the main @entity1 vector, @entity2 . Altogether, 209 proteins were identified by mass spectrometry. Among them were nine new chitin-binding peritrophic matrix proteins, expanding the list from three to twelve peritrophins. Lastly, we provide a model for the putative interactions among the proteins identified in this study.

title: The XXXX adult midgut peritrophic matrix proteome.

answer: @entity2


abstract: Many studies in Asia have demonstrated that Asian populations may require lower cut-off levels for body mass index (BMI) and waist circumference to define @entity2 and @entity5 respectively, compared to western populations. Optimal cut-off levels for body mass index and waist circumference were determined to assess the relationship between the two anthropometric- and cardiovascular indices. Receiver operating characteristics analysis was used to determine the optimal cut-off levels. The study sample included 1833 subjects (mean age of 44+/-14 years) from 93 primary care clinics in Malaysia. Eight hundred and seventy two of the subjects were @entity0 and 960 were @entity0 . The optimal body mass index cut-off values predicting dyslipidaemia, @entity4 , @entity1 , or at least one @entity3 factor varied from 23.5 to 25.5 kg/m2 in @entity0 and 24.9 to 27.4 kg/m2 in @entity0 . As for waist circumference, the optimal cut-off values varied from 83 to 92 cm in @entity0 and from 83 to 88 cm in @entity0 . The optimal cut-off values from our study showed that body mass index of 23.5 kg/m2 in @entity0 and 24.9 kg/m2 in @entity0 and waist circumference of 83 cm in @entity0 and @entity0 may be more suitable for defining the criteria for overweight or @entity2 among adults in Malaysia. Waist circumference may be a better indicator for the prediction of @entity2 -related @entity3 factors in @entity0 and @entity0 compared to BMI. Further investigation using a bigger sample size in Asia needs to be done to confirm our findings.

title: Optimal cut-off levels to define @entity2 : body mass index and waist circumference, and their relationship to XXXX , dyslipidaemia, @entity4 and @entity1 in Malaysia.

answer: @entity3


abstract: Many studies in Asia have demonstrated that Asian populations may require lower cut-off levels for body mass index (BMI) and waist circumference to define @entity2 and @entity5 respectively, compared to western populations. Optimal cut-off levels for body mass index and waist circumference were determined to assess the relationship between the two anthropometric- and cardiovascular indices. Receiver operating characteristics analysis was used to determine the optimal cut-off levels. The study sample included 1833 subjects (mean age of 44+/-14 years) from 93 primary care clinics in Malaysia. Eight hundred and seventy two of the subjects were @entity0 and 960 were @entity0 . The optimal body mass index cut-off values predicting dyslipidaemia, @entity4 , @entity1 , or at least one @entity3 factor varied from 23.5 to 25.5 kg/m2 in @entity0 and 24.9 to 27.4 kg/m2 in @entity0 . As for waist circumference, the optimal cut-off values varied from 83 to 92 cm in @entity0 and from 83 to 88 cm in @entity0 . The optimal cut-off values from our study showed that body mass index of 23.5 kg/m2 in @entity0 and 24.9 kg/m2 in @entity0 and waist circumference of 83 cm in @entity0 and @entity0 may be more suitable for defining the criteria for overweight or @entity2 among adults in Malaysia. Waist circumference may be a better indicator for the prediction of @entity2 -related @entity3 factors in @entity0 and @entity0 compared to BMI. Further investigation using a bigger sample size in Asia needs to be done to confirm our findings.

title: Optimal cut-off levels to define XXXX : body mass index and waist circumference, and their relationship to @entity3 , dyslipidaemia, @entity4 and @entity1 in Malaysia.

answer: @entity2


abstract: Many studies in Asia have demonstrated that Asian populations may require lower cut-off levels for body mass index (BMI) and waist circumference to define @entity2 and @entity5 respectively, compared to western populations. Optimal cut-off levels for body mass index and waist circumference were determined to assess the relationship between the two anthropometric- and cardiovascular indices. Receiver operating characteristics analysis was used to determine the optimal cut-off levels. The study sample included 1833 subjects (mean age of 44+/-14 years) from 93 primary care clinics in Malaysia. Eight hundred and seventy two of the subjects were @entity0 and 960 were @entity0 . The optimal body mass index cut-off values predicting dyslipidaemia, @entity4 , @entity1 , or at least one @entity3 factor varied from 23.5 to 25.5 kg/m2 in @entity0 and 24.9 to 27.4 kg/m2 in @entity0 . As for waist circumference, the optimal cut-off values varied from 83 to 92 cm in @entity0 and from 83 to 88 cm in @entity0 . The optimal cut-off values from our study showed that body mass index of 23.5 kg/m2 in @entity0 and 24.9 kg/m2 in @entity0 and waist circumference of 83 cm in @entity0 and @entity0 may be more suitable for defining the criteria for overweight or @entity2 among adults in Malaysia. Waist circumference may be a better indicator for the prediction of @entity2 -related @entity3 factors in @entity0 and @entity0 compared to BMI. Further investigation using a bigger sample size in Asia needs to be done to confirm our findings.

title: Optimal cut-off levels to define @entity2 : body mass index and waist circumference, and their relationship to @entity3 , dyslipidaemia, @entity4 and XXXX in Malaysia.

answer: @entity1


abstract: Many studies in Asia have demonstrated that Asian populations may require lower cut-off levels for body mass index (BMI) and waist circumference to define @entity2 and @entity5 respectively, compared to western populations. Optimal cut-off levels for body mass index and waist circumference were determined to assess the relationship between the two anthropometric- and cardiovascular indices. Receiver operating characteristics analysis was used to determine the optimal cut-off levels. The study sample included 1833 subjects (mean age of 44+/-14 years) from 93 primary care clinics in Malaysia. Eight hundred and seventy two of the subjects were @entity0 and 960 were @entity0 . The optimal body mass index cut-off values predicting dyslipidaemia, @entity4 , @entity1 , or at least one @entity3 factor varied from 23.5 to 25.5 kg/m2 in @entity0 and 24.9 to 27.4 kg/m2 in @entity0 . As for waist circumference, the optimal cut-off values varied from 83 to 92 cm in @entity0 and from 83 to 88 cm in @entity0 . The optimal cut-off values from our study showed that body mass index of 23.5 kg/m2 in @entity0 and 24.9 kg/m2 in @entity0 and waist circumference of 83 cm in @entity0 and @entity0 may be more suitable for defining the criteria for overweight or @entity2 among adults in Malaysia. Waist circumference may be a better indicator for the prediction of @entity2 -related @entity3 factors in @entity0 and @entity0 compared to BMI. Further investigation using a bigger sample size in Asia needs to be done to confirm our findings.

title: Optimal cut-off levels to define @entity2 : body mass index and waist circumference, and their relationship to @entity3 , dyslipidaemia, XXXX and @entity1 in Malaysia.

answer: @entity4


abstract: Background The @entity11 ( @entity12 ) mutation has been reported to be a cause of @entity2 . Recently, we detected this mutation in a large proportion of @entity0 with @entity6 , suggesting that in Italy the incidence of @entity11 ( @entity12 ) mutation could be underestimated. DESIGN AND METHODS: We extended the search for this mutation to all @entity0 with @entity10 who had a positive family history for @entity6 or @entity10 . We identified eight Italian families positive for the @entity11 ( @entity12 ) mutation. Clinical and hematologic data were available for members of seven families, including 21 @entity0 with a proven mutation and 20 relatives with @entity6 . RESULTS: Fifteen major @entity5 episodes, nine of which were fatal, were recorded among 41 @entity0 . The @entity5 manifestation was @entity1 in four cases, @entity4 in seven cases, fetal loss in two cases, @entity7 of the leg in one case and @entity8 in one case. Almost all @entity0 over 20 years old had @entity3 and @entity9 , while these were rarely observed in @entity0 under 20 years old, suggesting that these manifestations are associated with aging. Finally, the life expectancy of family members with @entity6 was significantly shorter than that of members without @entity6 (P=0.003). Conclusions @entity0 with @entity6 caused by a @entity11 ( @entity12 ) mutation have a high risk of @entity5 and, with aging, develop @entity3 and @entity9 , significantly affecting their life expectancy.

title: @entity2 caused by MPLSer505Asn is associated with a high @entity5 risk, @entity3 and progression to XXXX .

answer: @entity9


abstract: Background The @entity11 ( @entity12 ) mutation has been reported to be a cause of @entity2 . Recently, we detected this mutation in a large proportion of @entity0 with @entity6 , suggesting that in Italy the incidence of @entity11 ( @entity12 ) mutation could be underestimated. DESIGN AND METHODS: We extended the search for this mutation to all @entity0 with @entity10 who had a positive family history for @entity6 or @entity10 . We identified eight Italian families positive for the @entity11 ( @entity12 ) mutation. Clinical and hematologic data were available for members of seven families, including 21 @entity0 with a proven mutation and 20 relatives with @entity6 . RESULTS: Fifteen major @entity5 episodes, nine of which were fatal, were recorded among 41 @entity0 . The @entity5 manifestation was @entity1 in four cases, @entity4 in seven cases, fetal loss in two cases, @entity7 of the leg in one case and @entity8 in one case. Almost all @entity0 over 20 years old had @entity3 and @entity9 , while these were rarely observed in @entity0 under 20 years old, suggesting that these manifestations are associated with aging. Finally, the life expectancy of family members with @entity6 was significantly shorter than that of members without @entity6 (P=0.003). Conclusions @entity0 with @entity6 caused by a @entity11 ( @entity12 ) mutation have a high risk of @entity5 and, with aging, develop @entity3 and @entity9 , significantly affecting their life expectancy.

title: @entity2 caused by MPLSer505Asn is associated with a high @entity5 risk, XXXX and progression to @entity9 .

answer: @entity3


abstract: Background The @entity11 ( @entity12 ) mutation has been reported to be a cause of @entity2 . Recently, we detected this mutation in a large proportion of @entity0 with @entity6 , suggesting that in Italy the incidence of @entity11 ( @entity12 ) mutation could be underestimated. DESIGN AND METHODS: We extended the search for this mutation to all @entity0 with @entity10 who had a positive family history for @entity6 or @entity10 . We identified eight Italian families positive for the @entity11 ( @entity12 ) mutation. Clinical and hematologic data were available for members of seven families, including 21 @entity0 with a proven mutation and 20 relatives with @entity6 . RESULTS: Fifteen major @entity5 episodes, nine of which were fatal, were recorded among 41 @entity0 . The @entity5 manifestation was @entity1 in four cases, @entity4 in seven cases, fetal loss in two cases, @entity7 of the leg in one case and @entity8 in one case. Almost all @entity0 over 20 years old had @entity3 and @entity9 , while these were rarely observed in @entity0 under 20 years old, suggesting that these manifestations are associated with aging. Finally, the life expectancy of family members with @entity6 was significantly shorter than that of members without @entity6 (P=0.003). Conclusions @entity0 with @entity6 caused by a @entity11 ( @entity12 ) mutation have a high risk of @entity5 and, with aging, develop @entity3 and @entity9 , significantly affecting their life expectancy.

title: XXXX caused by MPLSer505Asn is associated with a high @entity5 risk, @entity3 and progression to @entity9 .

answer: @entity2


abstract: Background The @entity11 ( @entity12 ) mutation has been reported to be a cause of @entity2 . Recently, we detected this mutation in a large proportion of @entity0 with @entity6 , suggesting that in Italy the incidence of @entity11 ( @entity12 ) mutation could be underestimated. DESIGN AND METHODS: We extended the search for this mutation to all @entity0 with @entity10 who had a positive family history for @entity6 or @entity10 . We identified eight Italian families positive for the @entity11 ( @entity12 ) mutation. Clinical and hematologic data were available for members of seven families, including 21 @entity0 with a proven mutation and 20 relatives with @entity6 . RESULTS: Fifteen major @entity5 episodes, nine of which were fatal, were recorded among 41 @entity0 . The @entity5 manifestation was @entity1 in four cases, @entity4 in seven cases, fetal loss in two cases, @entity7 of the leg in one case and @entity8 in one case. Almost all @entity0 over 20 years old had @entity3 and @entity9 , while these were rarely observed in @entity0 under 20 years old, suggesting that these manifestations are associated with aging. Finally, the life expectancy of family members with @entity6 was significantly shorter than that of members without @entity6 (P=0.003). Conclusions @entity0 with @entity6 caused by a @entity11 ( @entity12 ) mutation have a high risk of @entity5 and, with aging, develop @entity3 and @entity9 , significantly affecting their life expectancy.

title: @entity2 caused by MPLSer505Asn is associated with a high XXXX risk, @entity3 and progression to @entity9 .

answer: @entity5


abstract: BACKGROUND: @entity10 is an anticonvulsant drug that has analgesic properties for acute @entity4 . However, the analgesic effect of @entity10 as an antiepileptic prophylactic drug on @entity0 undergoing craniotomy is unclear. In this study, we evaluated the postoperative effectiveness of @entity10 on acute @entity4 when it is used for antiepileptic prophylaxis in @entity0 undergoing craniotomy for @entity1 resection. METHODS: Eighty @entity0 undergoing craniotomy for @entity1 resection were randomly assigned into two groups. @entity0 in Group G (n = 40) received oral @entity10 (3 x 400 mg), and @entity0 in Group P (n = 40) received oral @entity11 (3 x 100 mg) for 7 days before the operation and postoperatively. An identical anesthesia protocol was performed for both the groups. Anesthesia was maintained with @entity8 and @entity9 infusion. @entity0 -controlled analgesia with @entity5 was used, and @entity3 levels were measured. The antiepileptic-related side effects, anesthetic consumption, duration of anesthesia and surgery, tracheal extubation time, @entity4 scores, @entity5 consumption, and sedation scores were recorded. RESULTS: Thirty-seven @entity0 in Group G and 38 @entity0 in Group P completed the study. During the preoperative period in Group G, one @entity0 had severe @entity6 , one had severe @entity7 , and one @entity0 's surgical procedure was changed. The median plasma levels of @entity10 were 34 micromol/mL (range, 23-51 micromol/mL) in 34 @entity0 . In Group P, one @entity0 withdrew from the study preoperatively and one developed transient @entity2 postoperatively. The demographic data and mean duration of anesthesia and surgery were similar in both the groups. The total @entity8 and @entity9 consumption in Group G (1847 +/- 548 mg/3034 +/- 1334 microg) was significantly less than that of Group P (2293 +/- 580 mg/4287 +/- 1282 microg) (P = 0.01). However, tracheal extubation could be done earlier in Group P (4.5 +/- 2 min) than in Group G (16.6 +/- 22 min) (P < 0.001). @entity3 scores were significantly higher in Group P at 15 min, 30 min, and 1 h (P < 0.001). The total @entity5 consumption was also significantly higher in Group P (33 +/- 17 mg vs 24 +/- 19 mg) (P = 0.01). The postoperative sedation scores were significantly higher in Group G at 15 min, 30 min, 1 h, and 2 h (P < 0.001). CONCLUSIONS: The administration of @entity10 to @entity0 undergoing craniotomy for @entity1 resection was effective for acute @entity4 . It also decreased analgesic consumption after surgery. However, it may lead to side effects such as delayed tracheal extubation and increased sedation postoperatively.

title: The analgesic effect of @entity10 as a prophylactic anticonvulsant drug on postcraniotomy XXXX : a prospective randomized study.

answer: @entity3


abstract: BACKGROUND: @entity10 is an anticonvulsant drug that has analgesic properties for acute @entity4 . However, the analgesic effect of @entity10 as an antiepileptic prophylactic drug on @entity0 undergoing craniotomy is unclear. In this study, we evaluated the postoperative effectiveness of @entity10 on acute @entity4 when it is used for antiepileptic prophylaxis in @entity0 undergoing craniotomy for @entity1 resection. METHODS: Eighty @entity0 undergoing craniotomy for @entity1 resection were randomly assigned into two groups. @entity0 in Group G (n = 40) received oral @entity10 (3 x 400 mg), and @entity0 in Group P (n = 40) received oral @entity11 (3 x 100 mg) for 7 days before the operation and postoperatively. An identical anesthesia protocol was performed for both the groups. Anesthesia was maintained with @entity8 and @entity9 infusion. @entity0 -controlled analgesia with @entity5 was used, and @entity3 levels were measured. The antiepileptic-related side effects, anesthetic consumption, duration of anesthesia and surgery, tracheal extubation time, @entity4 scores, @entity5 consumption, and sedation scores were recorded. RESULTS: Thirty-seven @entity0 in Group G and 38 @entity0 in Group P completed the study. During the preoperative period in Group G, one @entity0 had severe @entity6 , one had severe @entity7 , and one @entity0 's surgical procedure was changed. The median plasma levels of @entity10 were 34 micromol/mL (range, 23-51 micromol/mL) in 34 @entity0 . In Group P, one @entity0 withdrew from the study preoperatively and one developed transient @entity2 postoperatively. The demographic data and mean duration of anesthesia and surgery were similar in both the groups. The total @entity8 and @entity9 consumption in Group G (1847 +/- 548 mg/3034 +/- 1334 microg) was significantly less than that of Group P (2293 +/- 580 mg/4287 +/- 1282 microg) (P = 0.01). However, tracheal extubation could be done earlier in Group P (4.5 +/- 2 min) than in Group G (16.6 +/- 22 min) (P < 0.001). @entity3 scores were significantly higher in Group P at 15 min, 30 min, and 1 h (P < 0.001). The total @entity5 consumption was also significantly higher in Group P (33 +/- 17 mg vs 24 +/- 19 mg) (P = 0.01). The postoperative sedation scores were significantly higher in Group G at 15 min, 30 min, 1 h, and 2 h (P < 0.001). CONCLUSIONS: The administration of @entity10 to @entity0 undergoing craniotomy for @entity1 resection was effective for acute @entity4 . It also decreased analgesic consumption after surgery. However, it may lead to side effects such as delayed tracheal extubation and increased sedation postoperatively.

title: The analgesic effect of XXXX as a prophylactic anticonvulsant drug on postcraniotomy @entity3 : a prospective randomized study.

answer: @entity10


abstract: OBJECTIVES: To evaluate feasibility, technical success, and the need for reintervention in the early perioperative period, following the introduction of intraoperative DynaCT (DynaCT, Siemens AG, Berlin, Germany) in @entity0 undergoing @entity2 repair (EVAR). DynaCT involves the generation of computed tomography (CT)-like images from "on table" rotational angiographic acquisition. METHODS: A prospectively maintained database of 312 @entity0 undergoing EVAR (September 2001 - February 2007) was interrogated to determine incidence of early reintervention following satisfactory appearances of uniplanar completion angiography (control group). Following the introduction of DynaCT (DynaCT group - 80 @entity0 ), clinical and radiologic outcomes were prospectively evaluated (September 2007 - May 2008). Both groups underwent pre-discharge computed tomographic angiography (CTA) and color-flow duplex scan. Comparative analysis of procedural data, hospital-stay, mortality, and early reintervention between the two groups was undertaken. RESULTS: In the control group, 14 (4.5%) @entity0 required reintervention procedures within 30 days of EVAR (10 endovascular, 7 surgical). Six @entity0 had type 1 endoleaks and 8 presented with @entity1 . Review of this cohort suggested that the majority of complications (86%) may have been immediately identifiable with improved intra-operative quality control. In the DynaCT group, DynaCT was feasible in 81.3% (n = 65/80) of @entity0 and resulted in the detection of five clinically significant anomalies (6.25%, n = 5/80). These technical problems were not identified at completion angiography but were corrected after DynaCT (2 type 1 endoleaks, 1 type 3 endoleak, 1 limb compression, and 1 graft @entity3 ). Standard pre-discharge imaging did not identify any further graft-related complications in the DynaCT group. Introduction of DynaCT resulted in a reduced need for early reintervention (0/80 vs 14/312, P = .05). CONCLUSION: Most graft-related complications that mandate early reintervention following EVAR are due to remediable technical problems which are not identified by uniplanar completion angiography alone. DynaCT is a feasible intra-operative adjunct to completion angiography, which improves intra-operative quality control during endovascular repair of @entity4 .

title: Intra-operative DynaCT improves technical success of endovascular repair of XXXX .

answer: @entity4


abstract: We investigated the effects of dietary conjugated @entity3 ( @entity4 ) on @entity1 ( @entity1 ) in heavy @entity2 . Twelve @entity2 were assigned to 1 of 2 groups supplemented with either 0 or 0.75% of a @entity4 preparation (isomeric mixture) and were slaughtered at 159 +/- 2.3 kg live weight. Their subcutaneous @entity1 was analyzed by both chemical and microanatomical methods. The @entity1 of @entity4 -fed @entity2 tended to have a higher protein content (P = 0.064) and smaller adipocytes (P = 0.053) than that of control (CTR) @entity2 . The number of proliferating preadipocytes tended to be greater (P = 0.076) in @entity2 fed @entity4 , whereas the number of apoptotic adipocytes was greater (P < 0.01) than in CTR @entity2 . Immunohistochemistry revealed that leptin (Ob) expression was lower (P = 0.048) in adipocytes from treated @entity2 and Western blot quantification of Ob revealed lower levels (P < 0.05) in @entity4 -fed @entity2 . The @entity5 was not affected by dietary @entity4 supplementation. @entity0 hydroxylase activity was higher (P < 0.001) in @entity1 of @entity4 fed- @entity2 than in CTR. It is conceivable that the increased noradrenergic activity due to dietary @entity4 decreases the Ob expression, although it does not diminish the lipid content of @entity1 , at least in heavy @entity2 . This article describes the interaction between @entity4 and Ob in the @entity1 of heavy @entity2 and we hypothesize that there is an increased noradrenergic stimulation of lipolysis directly in the target tissue.

title: Dietary conjugated XXXX decrease leptin in porcine adipose tissue.

answer: @entity3


abstract: PURPOSE: To compare the incidence of @entity3 in anterior cruciate ligament (ACL) reconstruction with autograft versus allograft. METHODS: We completed a retrospective medical record review of ACL reconstructions performed at our institutions between 2001 and 2005. These included 170 autograft, 628 allograft, and 3 combined autograft/allograft reconstructions. Data collection included @entity0 demographics, comorbidities, preoperative antibiotics, fixation type, and the occurrence of @entity1 . RESULTS: Of the 801 @entity0 who underwent ACL reconstruction, 6 (0.75%) developed a confirmed @entity2 . There were 2 confirmed deep infections in 170 autograft reconstructions (1.2%) compared with 4 confirmed deep infections in 628 allograft reconstructions (0.6%). Multivariate analysis revealed that ACL reconstruction using autograft had a nearly twice the risk of @entity2 compared to allograft reconstructions (adjusted odds ratio, 1.83; 95% confidence interval, 0.16 to 12.94). CONCLUSIONS: This study failed to find a higher rate of deep @entity3 in ACL reconstructions when allograft tissue was used. We therefore feel that surgeons should consider allograft tissue as an alternative to autograft when there is a concern about donor-site morbidity, or for revision reconstructions. LEVEL OF EVIDENCE: Level III, therapeutic retrospective comparative study.

title: A retrospective comparison of the incidence of XXXX following anterior cruciate ligament reconstruction with autograft versus allograft.

answer: @entity3


abstract: BACKGROUND: The link between socioeconomic status (SES), @entity1 , dietary quality, and central adiposity remains unclear. OBJECTIVE: Pathways linking SES to dietary quality and central adiposity through @entity1 were examined across sex-ethnicity groups. DESIGN: Extensive data on US adults aged 30-64 y from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study were used in multiple linear logistic regression models and structural equation models to test pathway associations. Measures included Center for Epidemiologic Studies-Depression (CES-D) scores, 2005 Healthy Eating Index (HEI) values, and dual-energy X-ray absorptiometry. Sample sizes for most analyses ranged between 1789 for anthropometric outcomes and 1227 for trunk fat outcomes. RESULTS: The CES-D score was associated with lower HEI scores in all sex-ethnicity groups, except in African American @entity0 , and with higher waist-to-hip ratios (WHRs) among African American @entity0 . A CES-D score > or =16 was positively associated with waist circumference (WC) and with trunk fat among white @entity0 and @entity0 , respectively. SES was positively related to central adiposity among African American @entity0 ( @entity2 and WC) and African American @entity0 ( @entity2 and percentage trunk fat) but was inversely related to central adiposity among white @entity0 . Among whites only, the total positive effect of SES on HEI was significantly mediated by CES-D score. Among white @entity0 , the total inverse effect of SES on WC and WHR was significantly explained by the CES-D score and HEI, whereas the CES-D score was positively associated with WHR among African American @entity0 , independently of SES. CONCLUSION: Future mental health interventions targeted at reducing SES disparities in dietary quality and central adiposity may have different effects across sex-ethnicity groups.

title: Role of XXXX in explaining socioeconomic status disparities in dietary quality and central adiposity among US adults: a structural equation modeling approach.

answer: @entity1


abstract: @entity2 are primarily composed of extracellular aggregates of @entity4 ( @entity4 ) peptide and are a pathological signature of @entity1 . However, the factors that influence the dynamics of @entity2 formation and growth in vivo are largely unknown. Using serial intravital multiphoton microscopy through a thinned-skull cranial window in APP/ @entity5 @entity0 , we found that amyloid plaques appear and grow over a period of weeks before reaching a mature size. Growth was more prominent early after initial plaque formation: plaques grew faster in 6-month-old compared with 10-month-old @entity0 . Plaque growth rate was also size-related, as smaller plaques exhibited more rapid growth relative to larger plaques. Alterations in interstitial @entity4 concentrations were associated with changes in plaque growth. Parallel studies using multiphoton microscopy and in vivo microdialysis revealed that pharmacological reduction of soluble extracellular @entity4 by as little as 20-25% was associated with a dramatic decrease in plaque formation and growth. Furthermore, this small reduction in @entity4 synthesis was sufficient to reduce @entity2 load in 6-month-old but not 10-month-old @entity0 , suggesting that treatment early in disease pathogenesis may be more effective than later treatment. In contrast to thinned-skull windows, no significant plaque growth was observed under open-skull windows, which demonstrated extensive microglial and astrocytic activation. Together, these findings indicate that individual @entity2 growth in vivo occurs over a period of weeks and may be influenced by interstitial @entity4 concentration as well as reactive @entity3 .

title: Characterizing the appearance and growth of amyloid plaques in APP/ XXXX @entity0 .

answer: @entity5


abstract: @entity2 are primarily composed of extracellular aggregates of @entity4 ( @entity4 ) peptide and are a pathological signature of @entity1 . However, the factors that influence the dynamics of @entity2 formation and growth in vivo are largely unknown. Using serial intravital multiphoton microscopy through a thinned-skull cranial window in APP/ @entity5 @entity0 , we found that amyloid plaques appear and grow over a period of weeks before reaching a mature size. Growth was more prominent early after initial plaque formation: plaques grew faster in 6-month-old compared with 10-month-old @entity0 . Plaque growth rate was also size-related, as smaller plaques exhibited more rapid growth relative to larger plaques. Alterations in interstitial @entity4 concentrations were associated with changes in plaque growth. Parallel studies using multiphoton microscopy and in vivo microdialysis revealed that pharmacological reduction of soluble extracellular @entity4 by as little as 20-25% was associated with a dramatic decrease in plaque formation and growth. Furthermore, this small reduction in @entity4 synthesis was sufficient to reduce @entity2 load in 6-month-old but not 10-month-old @entity0 , suggesting that treatment early in disease pathogenesis may be more effective than later treatment. In contrast to thinned-skull windows, no significant plaque growth was observed under open-skull windows, which demonstrated extensive microglial and astrocytic activation. Together, these findings indicate that individual @entity2 growth in vivo occurs over a period of weeks and may be influenced by interstitial @entity4 concentration as well as reactive @entity3 .

title: Characterizing the appearance and growth of amyloid plaques in APP/ @entity5 XXXX .

answer: @entity0


abstract: A retrospective audit of all cases of @entity2 seen in genitourinary (GU) medicine clinics in Teesside was undertaken between 2005 and 2007. In all 80 @entity0 @entity2 was identified. Data on @entity0 sexuality, treatment, and serological follow-up and partner notification were collected and analysed. There were 48 heterosexual cases. There were 21 heterosexual males, and of the 27 females, 12 (44%) were diagnosed during antenatal care. Intramuscular injections of @entity5 penicillin were used to treat 75 out of the 80 @entity0 at the clinics. The remaining five @entity0 received oral therapy for two weeks: four had a course of @entity4 and one received @entity1 plus probenecid. The treatment rate of the population was 100%. In total, there were 115 contactable partners, of whom 87 (75.7%) were screened and/or treated. Successful treatment was defined as a four-fold or greater titre decrease in the @entity3 Reference Laboratory test within 3-6 months after treatment. Twenty-one @entity0 were excluded when assessing this due to incomplete serological follow-up. Satisfactory titre declines occurred in 56 (94.9%) of the 59 @entity0 . Overall, the clinics were shown to have adhered well with national standards. The rise in heterosexual and antenatal incidence is of concern.

title: Audit of XXXX : Teesside experience 2005-2007.

answer: @entity2


abstract: Anticancer agents, such as @entity4 , stimulate @entity2 , @entity3 , and behaviors indicative of malaise. @entity1 and @entity0 do not possess a @entity3 response, and, therefore, in these species, the ingestion of @entity7 clay (a pica response) has been used as an index of malaise. In the @entity1 , @entity4 -induced @entity7 intake is inhibited by antiemetic treatments. In addition, @entity4 activates vagal afferent fibers in the gut, and @entity7 intake induced by @entity4 is largely dependent on an intact vagus. Nevertheless, little is known about the brain pathways controlling pica. We investigated the role of the lateral parabrachial nucleus (lPBN), a major visceral afferent link between the hindbrain and forebrain, in @entity4 -induced @entity8 expression and pica. Injection of @entity4 (6 mg/kg ip) produced @entity8 expression in the @entity9 , a region receiving viscerosensory input. In @entity1 with bilateral @entity6 lPBN lesions, @entity4 treatment substantially increased @entity7 intake compared with controls ( approximately 30 g vs. approximately 5 g, respectively, over 24 h). Food intake was reduced by @entity4 treatment and by @entity5 , an emetic agent that acts centrally. Unlike @entity4 , however, @entity5 stimulated @entity7 intake to a similar degree in both the lesioned and control @entity1 , suggesting that lPBN damage neither produces nonspecific effects nor enhances malaise in general. These data suggest that lPBN-lesioned animals not only demonstrate pica after @entity4 treatment, but, in fact, show an exaggerated response that is greatly in excess of any treatment known to produce @entity7 intake in @entity1 .

title: Chemotherapy-induced XXXX intake is increased by lesion of the lateral parabrachial nucleus of the @entity1 .

answer: @entity7


abstract: Anticancer agents, such as @entity4 , stimulate @entity2 , @entity3 , and behaviors indicative of malaise. @entity1 and @entity0 do not possess a @entity3 response, and, therefore, in these species, the ingestion of @entity7 clay (a pica response) has been used as an index of malaise. In the @entity1 , @entity4 -induced @entity7 intake is inhibited by antiemetic treatments. In addition, @entity4 activates vagal afferent fibers in the gut, and @entity7 intake induced by @entity4 is largely dependent on an intact vagus. Nevertheless, little is known about the brain pathways controlling pica. We investigated the role of the lateral parabrachial nucleus (lPBN), a major visceral afferent link between the hindbrain and forebrain, in @entity4 -induced @entity8 expression and pica. Injection of @entity4 (6 mg/kg ip) produced @entity8 expression in the @entity9 , a region receiving viscerosensory input. In @entity1 with bilateral @entity6 lPBN lesions, @entity4 treatment substantially increased @entity7 intake compared with controls ( approximately 30 g vs. approximately 5 g, respectively, over 24 h). Food intake was reduced by @entity4 treatment and by @entity5 , an emetic agent that acts centrally. Unlike @entity4 , however, @entity5 stimulated @entity7 intake to a similar degree in both the lesioned and control @entity1 , suggesting that lPBN damage neither produces nonspecific effects nor enhances malaise in general. These data suggest that lPBN-lesioned animals not only demonstrate pica after @entity4 treatment, but, in fact, show an exaggerated response that is greatly in excess of any treatment known to produce @entity7 intake in @entity1 .

title: Chemotherapy-induced @entity7 intake is increased by lesion of the lateral parabrachial nucleus of the XXXX .

answer: @entity1


abstract: The @entity3 dehydration test (GDT) has been used to test for the presence of M  ni  re's disease and elicits acute alterations in vestibular reflexes in both normal and pathological states. Activation of the vestibulosympathetic reflex (VSR) increases muscle sympathetic nerve activity (MSNA) and peripheral vascular resistance. We hypothesized that the GDT would attenuate the VSR through fluid shifts of the inner ear. Sixteen male subjects (26    1 yr) were randomly assigned to be administered either @entity3 mixed with cranberry juice (97    3 ml @entity3 + equal portion of cranberry juice; n = 9) or a placebo control [water + cranberry juice (100 ml each); n = 7]. Subjects in both groups performed @entity4 ( @entity4 ), which engages the VSR, before and after administration of either the @entity3 or placebo. MSNA (microneurography), arterial blood pressure, and leg blood flow ( @entity2 plethysmography) were measured during @entity4 . Before @entity3 administration, @entity4 significantly increased MSNA burst frequency (/\8    1 bursts/min; P < 0.01) and total activity (/\77    18%; P < 0.01) and decreased @entity1 vascular conductance (-/\20    3%; P < 0.01). However, @entity4 performed postadministration of @entity3 resulted in an attenuated MSNA increase (/\3    1 bursts/min, /\22    3% total activity) and decrease in @entity1 vascular conductance (-/\7    4%). @entity4 significantly increased MSNA burst frequency (/\5    1 and /\5    2 bursts/min) and total activity (/\58    13% and /\52    18%) in the placebo group before and after placebo, respectively (P < 0.01). Likewise, decreases in @entity1 vascular conductance during @entity4 before and after placebo were not different (-/\13    4% and -/\14    2%, respectively; P < 0.01). These results suggest that fluid shifts of the inner ear via @entity3 dehydration attenuate the VSR. These data provide support that inner ear fluid dynamics can have a significant impact on blood pressure regulation via the VSR in @entity0 .

title: XXXX -induced fluid shifts attenuate the vestibulosympathetic reflex in @entity0 .

answer: @entity3


abstract: The @entity3 dehydration test (GDT) has been used to test for the presence of M  ni  re's disease and elicits acute alterations in vestibular reflexes in both normal and pathological states. Activation of the vestibulosympathetic reflex (VSR) increases muscle sympathetic nerve activity (MSNA) and peripheral vascular resistance. We hypothesized that the GDT would attenuate the VSR through fluid shifts of the inner ear. Sixteen male subjects (26    1 yr) were randomly assigned to be administered either @entity3 mixed with cranberry juice (97    3 ml @entity3 + equal portion of cranberry juice; n = 9) or a placebo control [water + cranberry juice (100 ml each); n = 7]. Subjects in both groups performed @entity4 ( @entity4 ), which engages the VSR, before and after administration of either the @entity3 or placebo. MSNA (microneurography), arterial blood pressure, and leg blood flow ( @entity2 plethysmography) were measured during @entity4 . Before @entity3 administration, @entity4 significantly increased MSNA burst frequency (/\8    1 bursts/min; P < 0.01) and total activity (/\77    18%; P < 0.01) and decreased @entity1 vascular conductance (-/\20    3%; P < 0.01). However, @entity4 performed postadministration of @entity3 resulted in an attenuated MSNA increase (/\3    1 bursts/min, /\22    3% total activity) and decrease in @entity1 vascular conductance (-/\7    4%). @entity4 significantly increased MSNA burst frequency (/\5    1 and /\5    2 bursts/min) and total activity (/\58    13% and /\52    18%) in the placebo group before and after placebo, respectively (P < 0.01). Likewise, decreases in @entity1 vascular conductance during @entity4 before and after placebo were not different (-/\13    4% and -/\14    2%, respectively; P < 0.01). These results suggest that fluid shifts of the inner ear via @entity3 dehydration attenuate the VSR. These data provide support that inner ear fluid dynamics can have a significant impact on blood pressure regulation via the VSR in @entity0 .

title: @entity3 -induced fluid shifts attenuate the vestibulosympathetic reflex in XXXX .

answer: @entity0


abstract: In the present study, we examined prolonged @entity2 after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three @entity0 strains (BALB/c, Swiss, and C57BL/6). Using this @entity0 model of @entity2 , we showed that antigen induction of @entity2 at more than one site led to a local suppression of active lesions, which increased the time course of experimental @entity6 ( @entity6 ). @entity2 with a simultaneous @entity2 of the peritoneum or a mucosal site appeared to cause prolonged @entity3 . Using knockout (KO) @entity0 , we observed that antigenic co-stimulation caused progressive illness in CD8-KO animals and an effective immune response in the absence of @entity5 . In @entity7 @entity0 , co-stimulation provoked @entity2 (not prolonged), suggesting that B1 B cells play an important role in the control of @entity3 . The tissue response to @entity2 was similar in all co-stimulated @entity0 groups, as anatomopathologic sections revealed @entity1 ( @entity4 -like). In general, these @entity0 had acute responses at primary antigenic sites with an intense migration of polymorphonuclear leukocytes (PMNs), whereas the distant @entity2 sites (footpad) showed signs of @entity2 . The migration of PMNs to the secondary site (footpad) increased in the later periods of @entity2 , especially after the disappearance of the primary antigenic focus. PMN migration was associated with lesion-dormancy breakage and fungal elimination. Our findings suggest that the host inflammatory/suppression mechanisms induced by antigenic co-stimulation to systemically fight the same pathogen act coordinately through responses that differ at the sites of @entity2 between acute and chronic integrated healing processes that are more prolonged than an acute @entity2 at a single site. However, the long persistence of fungal cells in the host may be linked to microbial adaptation to a @entity2 as observed in co-stimulated @entity7 @entity0 .

title: Prolonged infection by Fonsecaea pedrosoi after antigenic co-stimulation at different sites in experimental @entity0 XXXX .

answer: @entity6


abstract: In the present study, we examined prolonged @entity2 after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three @entity0 strains (BALB/c, Swiss, and C57BL/6). Using this @entity0 model of @entity2 , we showed that antigen induction of @entity2 at more than one site led to a local suppression of active lesions, which increased the time course of experimental @entity6 ( @entity6 ). @entity2 with a simultaneous @entity2 of the peritoneum or a mucosal site appeared to cause prolonged @entity3 . Using knockout (KO) @entity0 , we observed that antigenic co-stimulation caused progressive illness in CD8-KO animals and an effective immune response in the absence of @entity5 . In @entity7 @entity0 , co-stimulation provoked @entity2 (not prolonged), suggesting that B1 B cells play an important role in the control of @entity3 . The tissue response to @entity2 was similar in all co-stimulated @entity0 groups, as anatomopathologic sections revealed @entity1 ( @entity4 -like). In general, these @entity0 had acute responses at primary antigenic sites with an intense migration of polymorphonuclear leukocytes (PMNs), whereas the distant @entity2 sites (footpad) showed signs of @entity2 . The migration of PMNs to the secondary site (footpad) increased in the later periods of @entity2 , especially after the disappearance of the primary antigenic focus. PMN migration was associated with lesion-dormancy breakage and fungal elimination. Our findings suggest that the host inflammatory/suppression mechanisms induced by antigenic co-stimulation to systemically fight the same pathogen act coordinately through responses that differ at the sites of @entity2 between acute and chronic integrated healing processes that are more prolonged than an acute @entity2 at a single site. However, the long persistence of fungal cells in the host may be linked to microbial adaptation to a @entity2 as observed in co-stimulated @entity7 @entity0 .

title: Prolonged infection by Fonsecaea pedrosoi after antigenic co-stimulation at different sites in experimental XXXX @entity6 .

answer: @entity0


abstract: A @entity0 presenting severe @entity3 despite low or normal secretion of insulin was found to have IgM antibodies to the @entity4 . These antibodies stimulated lipogenesis in fat cells in vitro and competed with insulin for binding to insulin receptors. After treatment with glucocorticoids, the anti-receptor antibodies and the @entity3 both disappeared, and antibodies to insulin appeared in the patient's serum. The anti-insulin antibodies were isolated by affinity chromatography and were found to inhibit the anti- @entity4 antibodies that were present earlier. The interaction between the patient's anti-insulin antibodies and his anti-receptor antibodies suggests that these two species of antibodies are related as idiotypes and anti-idiotypes. We also studied the interaction of the hypoglycemic patient's anti-receptor antibodies with anti-insulin antibodies of a @entity1 @entity0 and with anti-insulin antibodies of @entity2 immunized to insulin. The hypoglycemic patient's anti-receptor antibodies were neutralized by the @entity1 patient's anti-insulin antibodies, indicating that anti-insulin antibodies with a common idiotype may arise in both @entity1 and @entity3 . Moreover, mouse anti-insulin antibodies that interacted with mouse anti-receptor antibodies neutralized the hypoglycemic patient's anti-receptor antibodies. In contrast, mouse anti-insulin antibodies that did not interact with the mouse anti-receptor antibodies did not neutralize the hypoglycemic patient's anti-receptor antibodies. Thus, the human anti-insulin antibodies share an idiotype with a specific class of mouse anti-insulin antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Antibodies to XXXX followed by anti-idiotype. Antibodies to insulin in @entity0 with @entity3 .

answer: @entity4


abstract: A @entity0 presenting severe @entity3 despite low or normal secretion of insulin was found to have IgM antibodies to the @entity4 . These antibodies stimulated lipogenesis in fat cells in vitro and competed with insulin for binding to insulin receptors. After treatment with glucocorticoids, the anti-receptor antibodies and the @entity3 both disappeared, and antibodies to insulin appeared in the patient's serum. The anti-insulin antibodies were isolated by affinity chromatography and were found to inhibit the anti- @entity4 antibodies that were present earlier. The interaction between the patient's anti-insulin antibodies and his anti-receptor antibodies suggests that these two species of antibodies are related as idiotypes and anti-idiotypes. We also studied the interaction of the hypoglycemic patient's anti-receptor antibodies with anti-insulin antibodies of a @entity1 @entity0 and with anti-insulin antibodies of @entity2 immunized to insulin. The hypoglycemic patient's anti-receptor antibodies were neutralized by the @entity1 patient's anti-insulin antibodies, indicating that anti-insulin antibodies with a common idiotype may arise in both @entity1 and @entity3 . Moreover, mouse anti-insulin antibodies that interacted with mouse anti-receptor antibodies neutralized the hypoglycemic patient's anti-receptor antibodies. In contrast, mouse anti-insulin antibodies that did not interact with the mouse anti-receptor antibodies did not neutralize the hypoglycemic patient's anti-receptor antibodies. Thus, the human anti-insulin antibodies share an idiotype with a specific class of mouse anti-insulin antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Antibodies to @entity4 followed by anti-idiotype. Antibodies to insulin in @entity0 with XXXX .

answer: @entity3


abstract: A @entity0 presenting severe @entity3 despite low or normal secretion of insulin was found to have IgM antibodies to the @entity4 . These antibodies stimulated lipogenesis in fat cells in vitro and competed with insulin for binding to insulin receptors. After treatment with glucocorticoids, the anti-receptor antibodies and the @entity3 both disappeared, and antibodies to insulin appeared in the patient's serum. The anti-insulin antibodies were isolated by affinity chromatography and were found to inhibit the anti- @entity4 antibodies that were present earlier. The interaction between the patient's anti-insulin antibodies and his anti-receptor antibodies suggests that these two species of antibodies are related as idiotypes and anti-idiotypes. We also studied the interaction of the hypoglycemic patient's anti-receptor antibodies with anti-insulin antibodies of a @entity1 @entity0 and with anti-insulin antibodies of @entity2 immunized to insulin. The hypoglycemic patient's anti-receptor antibodies were neutralized by the @entity1 patient's anti-insulin antibodies, indicating that anti-insulin antibodies with a common idiotype may arise in both @entity1 and @entity3 . Moreover, mouse anti-insulin antibodies that interacted with mouse anti-receptor antibodies neutralized the hypoglycemic patient's anti-receptor antibodies. In contrast, mouse anti-insulin antibodies that did not interact with the mouse anti-receptor antibodies did not neutralize the hypoglycemic patient's anti-receptor antibodies. Thus, the human anti-insulin antibodies share an idiotype with a specific class of mouse anti-insulin antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Antibodies to @entity4 followed by anti-idiotype. Antibodies to insulin in XXXX with @entity3 .

answer: @entity0


abstract: In this paper we report the @entity1 recorded on basal ECG, on Holter monitoring or on exercise test, in 32 pts affected by arrhythmogenic right ventricle (ARV). A sustained @entity2 ( @entity2 ) was present in 11 pts a non sustained @entity2 in 15 pts, a slow @entity2 in 2 pts, a @entity3 ( @entity3 ) in 3 pts and both sustained @entity2 and @entity3 in 1 pt. All but 1 case of sustained @entity2 showed a LBBB like pattern. The heart rate during @entity2 ranged between 170 and 280 beats/min. The frontal axis of the @entity2 showed a wide range of deviation. Among non sustained @entity2 , 9 cases had LBBB like pattern and 6 cases had polymorphic configuration. The 2 cases of slow @entity2 showed LBBB like pattern with right axis deviation. A comparison between @entity1 and @entity0 was made. The data obtained suggest that the effort plays an important role in the induction of @entity2 in pts with localized @entity0 . In conclusion a wide spectrum of @entity2 is present in the ARV. Probably the RV "arrhythmogenic" zones and the electrophysiological mechanism causing the @entity1 are various.

title: [Tachycardia and XXXX in the arrhythmogenic right ventricle (arrhythmogenic dysplasia of the right ventricle). Clinical and electrocardiographic spectrum].

answer: @entity3


abstract: Eighteen @entity0 with early @entity2 of various etiologies were tested with pattern and focal electroretinograms (macular ERGs), with high (400 cd/M2) and moderate (40 cd/M2) stimulus intensities and a four-alternative forced choice (4AFC) contrast sensitivity test in addition to intensive clinical examinations. High spatial frequency contrast sensitivity loss on the 4AFC test was the most striking and consistent feature of all cases. The only eyes not outside normal contrast sensitivity limits were three in which diagnosis was uncertain and the @entity0 had not recognized any problem, including two @entity3 . @entity2 also substantially reduced macular ERG amplitudes. Criterion scores on these tests separated @entity0 from normals more effectively than other noninvasive procedures and only missed one eye detected by contrast sensitivity. Latencies were affected but the delays were of no clinical significance in the individual case. Stimulus intensity was not critical. The results indicate that contrast sensitivity testing and macular ERGs are very reliable indices of central @entity1 at a stage when visible macular changes are too subtle for confident diagnosis. Contrast sensitivity has appeal because of its reliability, objectivity, simplicity, and noninvasive nature. It is equally applicable to @entity0 and adults. Pattern and focal ERGs can establish that the @entity1 has a retinal origin and can provide the most reliable objective confirmation.

title: Macular electroretinograms and contrast sensitivity as sensitive detectors of early XXXX .

answer: @entity2


abstract: Operations for pulmonary @entity1 were carried out on 33 @entity0 from January 1st 1976 to December 31st 1985 at the Surgical Division, University of Cologne. In six cases each, the @entity2 were @entity7 , @entity3 and osteocarcinoma. There were five cases of @entity6 , three cases of @entity4 , two cases of @entity4 and two cases of soft-tissue @entity5 as well as one case each of parotid, tonsillar and @entity4 . The large number of @entity1 could be determined in 21 cases (64%) by means of preoperative radiodiagnostics with X-rays of the chest in two planes, conventional tomography and computer tomography of the thorax. Computer tomography was the most efficient single investigation. 17 @entity0 received atypical resection and lobectomy was carried out in 16 cases. For all @entity0 , the cumulative survivals revealed a one-year actuarial survival of around 70% and a three-year actuarial survival of about 20%. @entity0 with several @entity1 (two to six) had a very much poorer prognosis than @entity0 with solitary pulmonary @entity1 . There was no connection between the surgical technique selected and the expected survival time in any case. The @entity2 -free interval between operation on the @entity2 and resection of the pulmonary @entity1 only had a slight prognostic significance.

title: [Diagnosis and surgical therapy of lung XXXX ].

answer: @entity1


abstract: The dimerization of avian @entity6 (PP) was studied by large-zone gel chromatography using integral boundary analysis. The association constant has been determined as a function of temperature and pH. The dimerization is endothermic and entropically driven, which suggests hydrophobic interactions, and is enhanced with increasing pH. Analysis of the pH dependence indicates the involvement of ionizable groups. with pKa values of 4.5-5.5. In the avian PP molecule, there are six groups which are potentially titratable in this pH range. A comparison of the @entity4 sequence of avian PP with that of the @entity1 and @entity0 homologues, which also exhibit pH-dependent dimerization [Noelken, M.E., Chang, P.J. _ Kimmel, J.R. (1980) Biochemistry (preceding paper in this issue)], shows that they have three @entity3 and two @entity2 groups in common. It is suggested that salt linkages involving these groups participate in dimerization. In the avian peptide, @entity5 -34 may also be involved.

title: Reversible dimerization of avian XXXX .

answer: @entity6


abstract: Carroll et al. reported that an abnormal @entity1 suppression test (DST) may identify approximately 50% of endogenous depressives and that normalization of the test occurs with clinical recovery. Brown et al. and Schlesser et al. have confirmed the diagnostic utility of the test. A preliminary study suggested that when the DST failed to normalize at discharge, @entity0 were at high risk for early relapse. In this study, we compared ten unipolar or bipolar endogenous depressives who had an abnormal DST on admission and a normal DST at discharge, with four @entity0 whose abnormal DST on admission failed to convert at discharge. On all measures, those whose DST fail to convert showed substantially less improvement. @entity0 whose DST fail to normalize may have incomplete resolution of their underlying depressive process. Despite clinical judgment that discharge may be appropriate these @entity0 may require further active treatment. Use of the DST prior to discharge may help discriminate between @entity0 whose remaining symptoms reflect situational or psychosocial problems and those with a continuing endogenomorphic process.

title: Normalization of XXXX suppression test: a laboratory index of recovery from endogenous depression.

answer: @entity1


abstract: BACKGROUND _ OBJECTIVES: Probability models for assessing a mosquito repellent's potential to reduce @entity2 transmission are not readily available to public health researchers. To provide a means for estimating the epidemiological efficacy of mosquito repellents in communities, we developed a simple mathematical model. STUDY DESIGN: A static probability model is presented to simulate @entity1 in a community during a single transmission season. The model includes five parameters- sporozoite rate, @entity0 @entity1 rate, biting pressure, repellent efficacy, and product-acceptance rate. INTERVENTIONS: The model assumes that a certain percentage of the population uses a personal mosquito repellent over the course of a seven-month transmission season and that this repellent maintains a constant rate of protective efficacy against the bites of @entity2 vectors. MAIN OUTCOME MEASURES: This model measures the probability of evading @entity1 in circumstances where vector biting pressure, repellent efficacy, and product acceptance may vary. [corrected] RESULTS _ CONCLUSION: Absolute protection using mosquito repellents alone requires high rates of repellent efficacy and product acceptance. [corrected] Using performance data from a highly effective repellent, the model estimates an 88.9% reduction of infections over a seven- month transmission season. A corresponding reduction in the incidence of @entity1 in community members not completely evading @entity1 can also be presumed. Thus, the model shows that mass distribution of a repellent with >98% efficacy and >98% product acceptance would suppress new @entity1 to levels lower than those achieved with insecticide treated nets (ITNs). A combination of both interventions could create synergies that result in reductions of disease burden significantly greater than with the use of ITNs alone.

title: Estimating a mosquito repellent's potential to reduce XXXX in communities.

answer: @entity2


abstract: BACKGROUND: The superiority of @entity3 and @entity2 (CisGem) chemotherapy over @entity2 ( @entity7 ) alone in @entity0 with @entity4 ( @entity4 ) has been demonstrated in two randomised trials; ABC02 and the Biliary Tract (BT) 22 study. We used a combined dataset from these two trials to investigate the derived neutrophil-to-lymphocyte ratio (dNLR), which is thought to be a prognostic factor associated with clinical outcomes in several solid @entity1 , including @entity4 . METHODS: White blood cell (WBC) and absolute neutrophil count (ANC) were available for 379 of 410 @entity0 from @entity4 -02 and all 83 @entity0 in @entity6 . The dNLR was calculated as ANC/(WBC-ANC), as previously specified. We examined the association between dNLR and @entity5 ( @entity5 ) and progression-free survival (PFS), as well as comparing the treatment effect in two @entity0 groups defined by their dNLR level. A high dNLR was defined as >= 3.0, which was approximately the upper tertile value. RESULTS: A total of 462 individual @entity0 records were analysed, 328 with baseline dNLR <3 and 134 with dNLR >= 3. There were 443 deaths in the cohort, and all surviving @entity0 had a dNLR <3. There was strong evidence that dNLR was closely associated with both @entity5 [hazard ratio (HR), 1.62; 95% confidence interval (CI) 1.32-2.01] and PFS (HR, 1.40; 95% CI 1.13-1.72). There was limited evidence (P = 0.10) of a differential effect of CisGem on @entity5 between the two dNLR groups, but this was clearest in the @entity4 -02 dataset (P = 0.06). There was good evidence (P = 0.008) of an association between low baseline dNLR and long-term survival on a CisGem regimen. There was also good evidence of an association between ECOG performance status (split at 0 and 1 versus 2) on both @entity5 (P < 0.001) and PFS (P = 0.01), but no evidence of a differential treatment effect, with both groups receiving benefit from the addition of @entity3 . CONCLUSIONS: These data confirm that high dNLR is associated with worse @entity5 and PFS, and suggests it may also be predictive of benefit for the addition of @entity3 to @entity2 in European @entity0 with @entity4 . Incorporating dNLR into the clinical context may better inform prognosis and chemotherapy decisions in @entity4 @entity0 .

title: Derived neutrophil lymphocyte ratio may predict benefit from XXXX in the advanced @entity1 : the @entity4 -02 and @entity6 studies.

answer: @entity3


abstract: BACKGROUND: The superiority of @entity3 and @entity2 (CisGem) chemotherapy over @entity2 ( @entity7 ) alone in @entity0 with @entity4 ( @entity4 ) has been demonstrated in two randomised trials; ABC02 and the Biliary Tract (BT) 22 study. We used a combined dataset from these two trials to investigate the derived neutrophil-to-lymphocyte ratio (dNLR), which is thought to be a prognostic factor associated with clinical outcomes in several solid @entity1 , including @entity4 . METHODS: White blood cell (WBC) and absolute neutrophil count (ANC) were available for 379 of 410 @entity0 from @entity4 -02 and all 83 @entity0 in @entity6 . The dNLR was calculated as ANC/(WBC-ANC), as previously specified. We examined the association between dNLR and @entity5 ( @entity5 ) and progression-free survival (PFS), as well as comparing the treatment effect in two @entity0 groups defined by their dNLR level. A high dNLR was defined as >= 3.0, which was approximately the upper tertile value. RESULTS: A total of 462 individual @entity0 records were analysed, 328 with baseline dNLR <3 and 134 with dNLR >= 3. There were 443 deaths in the cohort, and all surviving @entity0 had a dNLR <3. There was strong evidence that dNLR was closely associated with both @entity5 [hazard ratio (HR), 1.62; 95% confidence interval (CI) 1.32-2.01] and PFS (HR, 1.40; 95% CI 1.13-1.72). There was limited evidence (P = 0.10) of a differential effect of CisGem on @entity5 between the two dNLR groups, but this was clearest in the @entity4 -02 dataset (P = 0.06). There was good evidence (P = 0.008) of an association between low baseline dNLR and long-term survival on a CisGem regimen. There was also good evidence of an association between ECOG performance status (split at 0 and 1 versus 2) on both @entity5 (P < 0.001) and PFS (P = 0.01), but no evidence of a differential treatment effect, with both groups receiving benefit from the addition of @entity3 . CONCLUSIONS: These data confirm that high dNLR is associated with worse @entity5 and PFS, and suggests it may also be predictive of benefit for the addition of @entity3 to @entity2 in European @entity0 with @entity4 . Incorporating dNLR into the clinical context may better inform prognosis and chemotherapy decisions in @entity4 @entity0 .

title: Derived neutrophil lymphocyte ratio may predict benefit from @entity3 in the advanced XXXX : the @entity4 -02 and @entity6 studies.

answer: @entity1


abstract: BACKGROUND: The superiority of @entity3 and @entity2 (CisGem) chemotherapy over @entity2 ( @entity7 ) alone in @entity0 with @entity4 ( @entity4 ) has been demonstrated in two randomised trials; ABC02 and the Biliary Tract (BT) 22 study. We used a combined dataset from these two trials to investigate the derived neutrophil-to-lymphocyte ratio (dNLR), which is thought to be a prognostic factor associated with clinical outcomes in several solid @entity1 , including @entity4 . METHODS: White blood cell (WBC) and absolute neutrophil count (ANC) were available for 379 of 410 @entity0 from @entity4 -02 and all 83 @entity0 in @entity6 . The dNLR was calculated as ANC/(WBC-ANC), as previously specified. We examined the association between dNLR and @entity5 ( @entity5 ) and progression-free survival (PFS), as well as comparing the treatment effect in two @entity0 groups defined by their dNLR level. A high dNLR was defined as >= 3.0, which was approximately the upper tertile value. RESULTS: A total of 462 individual @entity0 records were analysed, 328 with baseline dNLR <3 and 134 with dNLR >= 3. There were 443 deaths in the cohort, and all surviving @entity0 had a dNLR <3. There was strong evidence that dNLR was closely associated with both @entity5 [hazard ratio (HR), 1.62; 95% confidence interval (CI) 1.32-2.01] and PFS (HR, 1.40; 95% CI 1.13-1.72). There was limited evidence (P = 0.10) of a differential effect of CisGem on @entity5 between the two dNLR groups, but this was clearest in the @entity4 -02 dataset (P = 0.06). There was good evidence (P = 0.008) of an association between low baseline dNLR and long-term survival on a CisGem regimen. There was also good evidence of an association between ECOG performance status (split at 0 and 1 versus 2) on both @entity5 (P < 0.001) and PFS (P = 0.01), but no evidence of a differential treatment effect, with both groups receiving benefit from the addition of @entity3 . CONCLUSIONS: These data confirm that high dNLR is associated with worse @entity5 and PFS, and suggests it may also be predictive of benefit for the addition of @entity3 to @entity2 in European @entity0 with @entity4 . Incorporating dNLR into the clinical context may better inform prognosis and chemotherapy decisions in @entity4 @entity0 .

title: Derived neutrophil lymphocyte ratio may predict benefit from @entity3 in the advanced @entity1 : the XXXX -02 and @entity6 studies.

answer: @entity4


abstract: BACKGROUND: The superiority of @entity3 and @entity2 (CisGem) chemotherapy over @entity2 ( @entity7 ) alone in @entity0 with @entity4 ( @entity4 ) has been demonstrated in two randomised trials; ABC02 and the Biliary Tract (BT) 22 study. We used a combined dataset from these two trials to investigate the derived neutrophil-to-lymphocyte ratio (dNLR), which is thought to be a prognostic factor associated with clinical outcomes in several solid @entity1 , including @entity4 . METHODS: White blood cell (WBC) and absolute neutrophil count (ANC) were available for 379 of 410 @entity0 from @entity4 -02 and all 83 @entity0 in @entity6 . The dNLR was calculated as ANC/(WBC-ANC), as previously specified. We examined the association between dNLR and @entity5 ( @entity5 ) and progression-free survival (PFS), as well as comparing the treatment effect in two @entity0 groups defined by their dNLR level. A high dNLR was defined as >= 3.0, which was approximately the upper tertile value. RESULTS: A total of 462 individual @entity0 records were analysed, 328 with baseline dNLR <3 and 134 with dNLR >= 3. There were 443 deaths in the cohort, and all surviving @entity0 had a dNLR <3. There was strong evidence that dNLR was closely associated with both @entity5 [hazard ratio (HR), 1.62; 95% confidence interval (CI) 1.32-2.01] and PFS (HR, 1.40; 95% CI 1.13-1.72). There was limited evidence (P = 0.10) of a differential effect of CisGem on @entity5 between the two dNLR groups, but this was clearest in the @entity4 -02 dataset (P = 0.06). There was good evidence (P = 0.008) of an association between low baseline dNLR and long-term survival on a CisGem regimen. There was also good evidence of an association between ECOG performance status (split at 0 and 1 versus 2) on both @entity5 (P < 0.001) and PFS (P = 0.01), but no evidence of a differential treatment effect, with both groups receiving benefit from the addition of @entity3 . CONCLUSIONS: These data confirm that high dNLR is associated with worse @entity5 and PFS, and suggests it may also be predictive of benefit for the addition of @entity3 to @entity2 in European @entity0 with @entity4 . Incorporating dNLR into the clinical context may better inform prognosis and chemotherapy decisions in @entity4 @entity0 .

title: Derived neutrophil lymphocyte ratio may predict benefit from @entity3 in the advanced @entity1 : the @entity4 -02 and XXXX studies.

answer: @entity6


abstract: OBJECTIVE: To investigate the strength of the association between victimisation by peers at age 13 years and @entity1 at 18 years. DESIGN: Longitudinal observational study. SETTING: Avon Longitudinal Study of Parents and @entity0 , a UK community based birth cohort. @entity0 : 6719 @entity0 who reported on peer victimisation at age 13 years. MAIN OUTCOME MEASURES: Depression defined according to international classification of diseases, 10th revision (ICD-10) criteria, assessed using the clinical interview schedule-revised during clinic assessments with @entity0 when they were aged 18 years. 3898 @entity0 had data on both victimisation by peers at age 13 years and @entity1 at age 18 years. RESULTS: Of the 683 @entity0 who reported frequent victimisation at age 13 years, 101 (14.8%) were @entity1 according to ICD-10 criteria at 18 years; of the 1446 @entity0 reporting some victimisation at age 13 years, 103 (7.1%) were @entity1 at age 18 years; and of the 1769 @entity0 reporting no victimisation at age 13 years, 98 (5.5%) were @entity1 at age 18 years. Compared with @entity0 who were not victimised those who were frequently victimised by peers had over a twofold increase in odds of @entity1 (odds ratio 2.96, 95% confidence interval 2.21 to 3.97, P<0.001). This association was slightly reduced when adjusting for confounders (2.32, 1.49 to 3.63, P<0.001). The population attributable fraction suggested that 29.2% (95% confidence interval 10.9% to 43.7%) of @entity1 at age 18 years could be explained by peer victimisation if this were a causal relation. CONCLUSION: When using observational data it is impossible to be certain that associations are causal. However, our results are consistent with the hypothesis that victimisation by peers in adolescence is associated with an increase in the risk of developing @entity1 as an adult.

title: Peer victimisation during adolescence and its impact on XXXX in early adulthood: prospective cohort study in the United Kingdom.

answer: @entity1