abstract: BACKGROUND: Totally implantable venous access port (TIVAP) implantation is one of the most often performed operations in general surgery (over 100,000/year in Germany). The two main approaches for TIVAP placement are insertion into the cephalic vein through an @entity2 ( @entity2 ) or closed cannulation technique of the subclavian vein (CC) with Seldinger technique. Both procedures are performed with high success rates and very low complication frequencies. Because of the low incidence of complications, no single interventional trial is able to report a valid comparison of peri- and @entity1 frequencies between both techniques. Therefore, the aim of this systematic review is to summarize evidence for peri- and @entity1 rates in @entity0 undergoing @entity2 or CC. METHODS/DESIGN: A systematic literature search will be conducted in The Cochrane Library, MEDLINE, and Embase to identify randomized controlled trials (RCTs), observational clinical studies (OCS), or case series (CS) reporting peri- and/or @entity1 of at least one implantation technique. A priori defined data will be extracted from included studies, and methodological quality will be assessed. Event rates with their 95% confidence intervals will be derived taking into account the follow-up time per study by @entity0 -months where appropriate. Pooled estimates of event rates with corresponding 95% confidence intervals will be calculated on the base of the Freeman-Tukey double arcsine transformation within a random effect model framework. DISCUSSION: The findings of this systematic review with proportional meta-analysis will help to identify the procedure with the best benefit/risk ratio for TIVAP implantation. This may have influence on daily practice, and data may be implemented in treatment guidelines. Considering the impact of TIVAP implantation on @entity0 ' well being together with its socioeconomic relevance, @entity0 will benefit from evidence-based treatment and health-care costs may also be reduced. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42013005180.

title: Closed cannulation of subclavian vein vs open cut-down of cephalic vein for totally implantable venous access port (TIVAP) implantation: protocol for a systematic review and proportional meta-analysis of perioperative and XXXX .

answer: @entity1


abstract: BACKGROUND: Postmastectomy breast reconstruction is an important component of @entity0 care, but few receive it at the time of the mastectomy. Virtually nothing is known about receipt of reconstruction after initial @entity2 therapy and why treatment might be delayed. MATERIALS AND METHODS: A 5-year follow-up survey was mailed to a population-based cohort of mastectomy-treated @entity0 @entity1 who were initially surveyed at time of diagnosis in 2002 and reported to the Los Angeles and Detroit SEER registries (N  =  645, response rate 60%). Outcomes were receipt of reconstruction (immediate [IR], delayed [DR], or none) and @entity1 appraisal of their treatment decisions. RESULTS: About one-third (35.9%) had IR, 11.5% had DR, and 52.6% had no reconstruction. One-third delayed reconstruction because they focused more on other @entity2 interventions, and nearly half were concerned about surgical complications and interference with @entity2 surveillance. Two-thirds of those with no reconstruction said that the procedure was not important to them. A large proportion of all @entity1 were satisfied with their reconstruction decision-making (89.4% IR, 78.4% DR, 80.4% no reconstruction, P  =  NS). However, only 59.3% of those with no reconstruction felt that they were adequately informed about their reconstructive options (vs 82.7% IR and 78.4% DR, P  <  .01). CONCLUSIONS: There was modest uptake of breast reconstruction after initial @entity2 treatment. Factors associated with delayed reconstruction were primarily related to uncertainty about the procedure, concern about @entity2 surveillance, and low priority. Those without reconstruction demonstrated significant informational needs, which should be addressed with future research efforts.

title: Receipt of delayed breast reconstruction after mastectomy: do XXXX revisit the decision?

answer: @entity1


abstract: 1. The membrane properties of the longitudinal muscle layer of the @entity0 rectum were studied in @entity2 solution (twice the normal Krebs by addition of @entity1 ) by the micro-electrode technique. To produce the electrotonic potential and spike, stimulating partitions were used.2. @entity2 solution hyperpolarized the membrane and increased the membrane resistance. However, no change in the space constant was observed before and after treatment with @entity2 solution.3. The appearance and amplitude of the spike became regular after treatment with @entity2 solution and appearance of the overshoot was consistent.4. The characteristic constants and the conduction velocity were measured in @entity2 solution.(i) The space constant of the membrane was 0.81 mm, the time constant of the electrotonic potential was 83.7 msec and the time constant of the foot of the propagated spike was 8.8 msec.(ii) The conduction velocity of the excitation measured by insertions of the two micro-electrodes was 4.4 cm/sec.(iii) The chronaxie of the membrane was 71.3 msec.5. The results obtained from the present experiments were discussed in relation to the cable theory, and it was concluded that the passive properties of the membrane of the rectal smooth muscle could be explained by the cable equations.6. The specificities of the electrical properties of rectal smooth muscle were compared with muscle from other regions of the alimentary canal.

title: Biophysical properties of the longitudinal smooth muscle of the XXXX rectum.

answer: @entity0


abstract: 1. Changes in the endocochlear potential between the 8th and 18th days after birth were investigated in the @entity0 . Initially the potential was low but its magnitude increased rapidly between the 11th and 16th day. During the 13th and 14th days the rate of increase was approximately 1 mV/hr.2. The rapid potential increase arose virtually simultaneously in all three turns of the cochlea.3. Histological examination revealed the cochlea, including the hair cells of Corti's organ and the stria vascularis, to be fully mature before the period of rapid change in the endocochlear potential, apart from the cells of Claudius, whose final development coincided with the latter part of this phase.4. The endolymphatic @entity3 concentration (average 1.0 m-equiv/l.) had attained the very low adult level in the earliest period studied. The @entity2 and @entity4 concentrations were slightly below the normal adult levels, the result of some degree of general @entity5 present at this time.5. The endolymphatic ionic concentrations remained unchanged during the phase of rapid increase in the endocochlear potential.6. The findings thus indicate that the distinctive endolymphatic ionic composition and the endocochlear potential arise largely independently and in succession during cochlear maturation.7. No differences in osmotic pressure were demonstrated between endolymph, perilymph and serum. The problems concerning the homoeostasis of the inner ear fluids do not consequently seem to be complicated by unusual hydrodynamic aspects.8. Alterations in body fluid osmolality, produced by intraperitoneal injection of water or hypertonic @entity1 , were accompanied by simultaneous changes in the osmotic pressures of the inner ear fluids. Some portion of the membranes bounding the endolymphatic space is therefore considered to be freely permeable to water.9. The investigations provide no further information about the nature of the endocochlear potential, although an increase in the electrical resistance of the cochlear duct membranes is thought responsible for its appearance. The time relationships of this period support the concept that the potential is an essential feature of the mechano-electric transduction process.

title: A study of the electrochemistry and osmotic relationships of the cochlear fluids in the neonatal XXXX at the time of the development of the endocochlear potential.

answer: @entity0


abstract: UNASSIGNED: Background: The aim of this study was to evaluate the stability over time of the individually defined interval of intravitreal ranibizumab injection (IVR) for the treatment of recurrent @entity1 ( @entity1 ) in central @entity2 (CRVO). @entity0 and Methods: A case series of treatment na  ve @entity0 followed in the Jules Gonin Eye Hospital for @entity1 due to central @entity2 is presented. @entity0 were treated monthly with IVR until complete absence of fluid on qualitative SD-OCT with a minimum of 5 monthly IVR. Thereafter, they were followed according to a modified treat and extend regimen ( @entity3 ). Results: Twelve eyes (12 @entity0 ) with @entity1 due to CRVO were included. The mean follow-up period was 31.3 months. Analysis showed that best corrected visual acuity (BCVA), central macular thickness and qualitative spectral domain optical coherence tomography (SD-OCT) showed comparable results under monthly interval, after titration of an individualized interval and when performed in a series. 78% of treating intervals were within      2 weeks of the first individually adjusted interval. The mean first defined interval was 4.3 weeks and the mean interval over time was 5.5 weeks (p   =   0.003). There was a trend towards longer interval over time. Conclusion: The adjusted interval of retreatment of @entity0 with @entity1 due to CRVO showed a high stability with a trend toward longer duration over time. An @entity3 regimen seems to be valuable to follow @entity0 with @entity1 with good stabilization of VA.

title: Recurrent XXXX in Central @entity2 Treated with Intravitreal Ranibizumab using a Modified Treat and Extend Regimen.

answer: @entity1


abstract: UNASSIGNED: Background: The aim of this study was to evaluate the stability over time of the individually defined interval of intravitreal ranibizumab injection (IVR) for the treatment of recurrent @entity1 ( @entity1 ) in central @entity2 (CRVO). @entity0 and Methods: A case series of treatment na  ve @entity0 followed in the Jules Gonin Eye Hospital for @entity1 due to central @entity2 is presented. @entity0 were treated monthly with IVR until complete absence of fluid on qualitative SD-OCT with a minimum of 5 monthly IVR. Thereafter, they were followed according to a modified treat and extend regimen ( @entity3 ). Results: Twelve eyes (12 @entity0 ) with @entity1 due to CRVO were included. The mean follow-up period was 31.3 months. Analysis showed that best corrected visual acuity (BCVA), central macular thickness and qualitative spectral domain optical coherence tomography (SD-OCT) showed comparable results under monthly interval, after titration of an individualized interval and when performed in a series. 78% of treating intervals were within      2 weeks of the first individually adjusted interval. The mean first defined interval was 4.3 weeks and the mean interval over time was 5.5 weeks (p   =   0.003). There was a trend towards longer interval over time. Conclusion: The adjusted interval of retreatment of @entity0 with @entity1 due to CRVO showed a high stability with a trend toward longer duration over time. An @entity3 regimen seems to be valuable to follow @entity0 with @entity1 with good stabilization of VA.

title: Recurrent @entity1 in Central XXXX Treated with Intravitreal Ranibizumab using a Modified Treat and Extend Regimen.

answer: @entity2


abstract: OBJECTIVE: To calculate the numbers of @entity1 and prevalence of @entity2 , and to predict future trend of @entity2 incidences in South Korea. METHODS: Weekly incidences of @entity2 for 13 years from the period 2001-2013 in South Korea were analyzed. The back-calculation equations were used with incubation period distributions. The maximum likelihood estimation for Poisson model was also used. The confidence intervals of the estimates were obtained by a bootstrap method. A regression model for time series of @entity2 incidences over 13 years was fitted by the non-linear least squares method, and used to predict futuretrend. RESULTS: The estimated @entity1 curve is narrower and more concentrated in the summer than in the incidence distribution. Infection started around the 19th week and was over around the 41st week. The maximum weekly @entity1 110 was obtained at the 29th week. The prevalence at the first week was around 496 @entity0 , the minimum number was 366 at 22nd week, and the maximum prevalence was 648 at 34th week. Prevalence drops in late spring with @entity0 that falling ill and had had long incubation periods and rose in the summer with new @entity1 . Our future forecast based on the regression model was that an increase at year 2014 compared to 2013 may reach a peak (at maximum about 70 weekly cases) at year 2015, with a decreasing trend after then. CONCLUSIONS: This work shows that back-calculation methods could work well in estimating the @entity1 rates and the prevalence of @entity2 . The obtained results can be useful in establishing an efficient preventive program for @entity1 . The method presented here can be used in other countries where incidence data and incubation period are available.

title: Statistical estimations for Plasmodium vivax XXXX in South Korea.

answer: @entity2


abstract: UNASSIGNED: Purpose To investigate the cardiac computed tomographic (CT) findings and clinical implications of @entity2 in @entity0 who have undergone aortic valve replacement. Materials and Methods The institutional review board approved this retrospective study, and the need to obtain written informed consent was waived. From April 2011 to March 2012, 88 @entity0 (mean age, 63 years; 45 @entity0 ) with a prosthetic aortic valve who underwent @entity1 were retrospectively selected. Dynamic @entity1 images were analyzed by using a multiplanar reformatted technique. The presence or absence of @entity2 and its extent were evaluated at @entity1 . The geometric orifice area and the effective orifice area of each prosthetic valve were measured to enable analysis of the @entity2 encroachment ratio in the systolic phase. Hemodynamic parameters at echocardiography, including mean transprosthetic pressure gradient (MTPG), were compared between @entity0 with and those without @entity2 . The encroachment ratio and the MTPG were correlated by using the Spearman test to evaluate the relationship between the two variables. Results Seventeen @entity0 (19%) had @entity2 at @entity1 . In @entity0 with @entity2 , MTPG, peak pressure gradient, transvalvular peak velocity, and left ventricular ejection fraction (LVEF) were significantly higher than in @entity0 without @entity2 (MTPG: 28.1 mm Hg    19.8 [standard deviation] vs 14.0 mm Hg    6.5, P = .004; peak pressure gradient: 53.1 mm Hg    38.4 vs 26.1 mm Hg    11.4, P = .004; transvalvular peak velocity: 3.3 m/sec    1.3 vs 2.5 m/sec    0.5; and LVEF: 64.7%    7.4 vs 56.8%    10.5, P = .004). A high MTPG (>= 40 mm Hg) was observed in four @entity0 at echocardiography, and subprosthetic panni were identified at CT in all four @entity0 . In @entity0 with increased MTPGs, the encroachment ratio by @entity2 at CT was significantly higher than that in @entity0 with MTPGs of less than 40 mm Hg (42.7    13.3 vs 7.6    3, P = .012). Conclusion Cardiac CT revealed @entity2 to be a cause of the hemodynamic changes in @entity0 who had undergone aortic valve replacement. By helping quantify the encroachment ratio by @entity2 , @entity1 may help differentiate which subprosthetic panni might lead to substantial flow limitation over the prosthetic aortic valve. (  ) RSNA, 2015.

title: XXXX after Aortic Valve Replacement Surgery: Cardiac CT Findings and Clinical Features.

answer: @entity2


abstract: The aggregation of @entity2 (a- @entity3 ) is linked to @entity0 . The mechanism of @entity1 steps and the effect of pathogenic single-point mutations remain elusive. We report here a single-molecule fluorescence study of a- @entity3 dimerization and the effect of mutations. Specific interactions between tethered fluorophore-free a- @entity3 monomers on a substrate and fluorophore-labeled monomers diffusing freely in solution were observed using total internal reflection fluorescence microscopy. The results showed that wild-type (WT) a- @entity3 dimers adopt two types of dimers. The lifetimes of type 1 and type 2 dimers were determined to be 197    3  ms and 3334    145  ms, respectively. All three of the mutations used, @entity4 , @entity6 , and @entity5 , increased the lifetime of type 1 dimer and enhanced the relative population of type 2 dimer, with type 1 dimer constituting the major fraction. The kinetic stability of type 1 dimers (expressed in terms of lifetime) followed the order @entity4 (693    14  ms) > @entity6 (292    5  ms) > @entity5 (226    6  ms) > WT (197    3  ms). Type 2 dimers, which are more stable, had lifetimes in the range of several seconds. The strongest effect, observed for the @entity4 mutant, resulted in a lifetime 3.5 times higher than observed for the WT type 1 dimer. This mutation also doubled the relative fraction of type 2 dimer. These data show that single-point mutations promote dimerization, and they suggest that the structural heterogeneity of a- @entity3 dimers could lead to different aggregation pathways.

title: Direct Detection of XXXX Dimerization Dynamics: Single-Molecule Fluorescence Analysis.

answer: @entity2


abstract: BACKGROUND: The nodal status of primary @entity2 is of prognostic value for survival after the resection for colorectal liver metastases (CRLM). However, in the past decade, effective adjuvant chemotherapy for lymph node positive primary @entity3 was introduced. This study evaluated the prognostic value of primary lymph node status in @entity0 with resectable metachronous CRLM in the @entity4 of effective systemic therapy. METHODS: Between January 2000 and December 2011, all consecutive @entity0 undergoing curative liver resection for CRLM were retrospectively analyzed. Overall survival (OS) was analyzed by the localization of the @entity1 (colon vs. rectum) and by lymph node status (positive vs. negative) of the @entity1 . RESULTS: A total of 286 @entity0 with metachronous CRLM's were selected. Five-year OS was similar for colon and rectal primaries (42 and 40%, p = 0.62). Lymph node positivity was only a prognostic factor in rectal primaries (N+ 32% vs. N0 49%, p = 0.04) and not in colon primaries (N+ 42% vs. N0 41%, p = 0.99). In multivariate analysis, these results were confirmed. CONCLUSION: The current study demonstrates that the nodal status of primary @entity3 does not have prognostic value in @entity0 undergoing resection for metachronous CRLM. A possible explanation might be the administration of effective adjuvant chemotherapy in node positive @entity3 .    2015 S. Karger AG, Basel.

title: The Prognostic Value of the @entity1 's Nodal Status after Surgery for Colorectal Liver Metastases in the XXXX of Effective Systemic Therapy.

answer: @entity4


abstract: BACKGROUND: The nodal status of primary @entity2 is of prognostic value for survival after the resection for colorectal liver metastases (CRLM). However, in the past decade, effective adjuvant chemotherapy for lymph node positive primary @entity3 was introduced. This study evaluated the prognostic value of primary lymph node status in @entity0 with resectable metachronous CRLM in the @entity4 of effective systemic therapy. METHODS: Between January 2000 and December 2011, all consecutive @entity0 undergoing curative liver resection for CRLM were retrospectively analyzed. Overall survival (OS) was analyzed by the localization of the @entity1 (colon vs. rectum) and by lymph node status (positive vs. negative) of the @entity1 . RESULTS: A total of 286 @entity0 with metachronous CRLM's were selected. Five-year OS was similar for colon and rectal primaries (42 and 40%, p = 0.62). Lymph node positivity was only a prognostic factor in rectal primaries (N+ 32% vs. N0 49%, p = 0.04) and not in colon primaries (N+ 42% vs. N0 41%, p = 0.99). In multivariate analysis, these results were confirmed. CONCLUSION: The current study demonstrates that the nodal status of primary @entity3 does not have prognostic value in @entity0 undergoing resection for metachronous CRLM. A possible explanation might be the administration of effective adjuvant chemotherapy in node positive @entity3 .    2015 S. Karger AG, Basel.

title: The Prognostic Value of the XXXX 's Nodal Status after Surgery for Colorectal Liver Metastases in the @entity4 of Effective Systemic Therapy.

answer: @entity1


abstract: AIMS: Adipocytes play a critical role in energy balance. Growth of fat tissue is achieved via an increase in adipocyte mass and the formation of newly differentiated adipocytes from precursor cells. Understanding the cellular and molecular mechanisms of adipocyte differentiation is crucial for the study of @entity0 - and fat-related diseases. The present study was designed to study whether small heterodimer partner-interacting @entity1 zipper protein ( @entity5 ), a novel co-repressor, could regulate differentiation of adipocyte in 3T3-L1 cells. MATERIALS AND METHODS: Treatment of endoplasmic stress inducers, @entity3 and @entity2 , inhibited adipocyte differentiation, stimulated @entity5 mRNA expression, and repressed the expression of adiponectin ( @entity4 ) in 3T3-L1 pre-adipocyte. Overexpression of @entity5 in 3T3-L1 cells decreased the expression of the mRNA encoding @entity4 , a major marker of adipocytes, significantly. Furthermore, knockdown of @entity5 recovered the @entity3 -mediated repression of @entity4 transcription. Co-immunoprecipitation experiments revealed that @entity5 interacted physically with PPARy in 3T3-L1 cells. In addition, chromatin immunoprecipitation experiments revealed that @entity5 suppressed the binding affinity of PPARy for the @entity4 promoter. KEY FINDINGS: we demonstrate that @entity5 controls adipocyte differentiation by regulating the transactivity of peroxisome proliferator-activated receptor y (PPARy). SIGNIFICANCE: These findings demonstrate that @entity5 represses adipocyte differentiation by regulating PPARy transactivity; hence, @entity5 is a potential regulator of PPARy-related diseases.

title: Small heterodimer partner-interacting XXXX zipper protein inhibits adipogenesis by regulating Peroxisome proliferator-activated receptor y activity.

answer: @entity1


abstract: OBJECTIVE: To investigate the comparative effectiveness of current standard treatment, against an individually tailored behavioural programme delivered via the Internet or face-to-face for @entity0 with acute @entity3 associated disorders. DESIGN: A multicentre, randomized, three-group design, with concealed allocation. SUBJECTS AND SETTINGS: A total of 55 @entity0 (37 female), age 18-65, with acute @entity1 (Grade I-II), recruited at two emergency clinics in Sweden. INTERVENTIONS: Before randomization all @entity0 received standard self-care instructions. The Internet and face-to-face groups followed a seven-week behavioural programme involving individual tailoring, via email (Internet group), or in sessions at a physical therapy unit (face-to-face group). The control group only received the self-care instructions. MAIN MEASURES: @entity2 , @entity2 intensity, self-efficacy in daily activities, catastrophizing and fear of movement/(re)injury. Assessments were performed at baseline (2-4   weeks postinjury) and at three, six and 12   months postintervention. RESULTS: Both the Internet (n   =   16) and face-to-face (n   =   14) group showed a larger decrease in @entity2 than the control group (n   =   16); -12 and -11, respectively, compared with -5 in the control group at 12-months follow-up. Significant differences between the groups in overall treatment effect were shown in all outcomes except @entity2 intensity. All groups improved significantly over time in all outcomes, except for fear of movement/(re)injury and catastrophizing in the control group. CONCLUSION: An individually tailored behavioural programme improved biopsychosocial factors in @entity0 with @entity3 associated disorders up to 12   months after treatment. Internet-delivered intervention was as effective as clinic-based face-to-face therapy sessions.

title: What is the comparative effectiveness of current standard treatment, against an individually tailored behavioural programme delivered either on the Internet or face-to-face for @entity0 with acute XXXX ? A randomized controlled trial.

answer: @entity1


abstract: OBJECTIVE: To investigate the comparative effectiveness of current standard treatment, against an individually tailored behavioural programme delivered via the Internet or face-to-face for @entity0 with acute @entity3 associated disorders. DESIGN: A multicentre, randomized, three-group design, with concealed allocation. SUBJECTS AND SETTINGS: A total of 55 @entity0 (37 female), age 18-65, with acute @entity1 (Grade I-II), recruited at two emergency clinics in Sweden. INTERVENTIONS: Before randomization all @entity0 received standard self-care instructions. The Internet and face-to-face groups followed a seven-week behavioural programme involving individual tailoring, via email (Internet group), or in sessions at a physical therapy unit (face-to-face group). The control group only received the self-care instructions. MAIN MEASURES: @entity2 , @entity2 intensity, self-efficacy in daily activities, catastrophizing and fear of movement/(re)injury. Assessments were performed at baseline (2-4   weeks postinjury) and at three, six and 12   months postintervention. RESULTS: Both the Internet (n   =   16) and face-to-face (n   =   14) group showed a larger decrease in @entity2 than the control group (n   =   16); -12 and -11, respectively, compared with -5 in the control group at 12-months follow-up. Significant differences between the groups in overall treatment effect were shown in all outcomes except @entity2 intensity. All groups improved significantly over time in all outcomes, except for fear of movement/(re)injury and catastrophizing in the control group. CONCLUSION: An individually tailored behavioural programme improved biopsychosocial factors in @entity0 with @entity3 associated disorders up to 12   months after treatment. Internet-delivered intervention was as effective as clinic-based face-to-face therapy sessions.

title: What is the comparative effectiveness of current standard treatment, against an individually tailored behavioural programme delivered either on the Internet or face-to-face for XXXX with acute @entity1 ? A randomized controlled trial.

answer: @entity0


abstract: BACKGROUND: Due to the growing use of various types of industrial and agricultural machinery, occupational accidents are among the most serious ones and quite frequently result in the permanent posttraumnatic disability of the injured @entity0 . In Poland, a replantation service has been operating since 2010. Each day, one out of six centres provides emergency replantation service accepting amputation calls from across the country. @entity0 qualified for replantation often need to be transported from places located even several hundred kilometres from the target hospital. MATERIAL AND METHODS: The analysis covered 174 @entity2 ( @entity2 ) missions and 112 interhospital transports. The data were obtained as a result of a retrospective analysis of the air and medical documentation of 23 460 missions carried out by the Polish Medical Air Rescue (Samodzielny Publiczny @entity4  ad Opieki Zdrowotnej Lotnicze Pogotowie Ratunkowe - SP ZOZ LPR) aircrafts in the years 2011-2013. RESULTS: In the period under study, the Polish Medical Air Rescue helicopters dressed 135 @entity0 with @entity3 amputations at the scene and transported them to hospitals as part of @entity2 missions. At the same time, SP ZOZ LPR aircrafts made 102 interhospital transports. Ninety @entity0 were qualified for treatment in replantation service centres. The average air transport time was 76 min, while the total transport time was 172.3 min. With transport exceeding 300 kin, the average time advantage over the ground transport was approximately 1.5 h. CONCLUSIONS: In justified cases, the use of helicopters and airplanes is an optimal method of transporting @entity0 with the major @entity1 to upper extremities.

title: [Rescue procedures in the major XXXX of upper extremities - the role of the Polish medical air rescue in the therapeutic process].

answer: @entity1


abstract: INTRODUCTION: @entity7 frequently begins in childhood, and is characterized by excessive @entity1 , with the presence of @entity8 reflecting a more severe phenotype. @entity7 may result from genetic predisposition involving deregulation of immune pathways, particularly involving T helper 2 cells (Th2). Increased activation of Th2 cells is usually manifested as @entity2 such as @entity6 , @entity3 , and @entity4 . We hypothesized that the presence of @entity2 indicative of increased Th2 balance may dampen the severity of the phenotype in @entity0 with @entity7 . METHODS: A retrospective chart review of childhood @entity7 @entity0 was conducted at three major pediatric sleep centers. @entity0 were divided into those with @entity7 without @entity8 (NC-) and @entity7 with @entity8 (NC+). Demographics, polysomnographic and Multiple Sleep Latency Test data, and extraction of information on the presence of @entity2 such @entity5 , @entity3 , and @entity4 was performed. RESULTS: There were 468 @entity0 identified, with 193 @entity0 in NC- group and 275 @entity0 in the NC+ group. Overall, NC+ @entity0 were significantly younger, had higher body mass index, and had shorter mean sleep latencies and increased sleep onset rapid eye movement events. The frequency of @entity2 , particularly @entity4 and @entity5 , was markedly lower in NC+ (58/275) compared to NC- @entity0 (94/193; P < 0.0001). CONCLUSION: Involvement of the immune system plays an important role in the pathophysiology of @entity7 . Current findings further suggest that an increased shift toward Th2, as indicated by the presence of @entity2 , may modulate the severity of the phenotype in childhood @entity7 , and reduce the prevalence of @entity8 in these @entity0 .

title: Allergies and Disease Severity in XXXX : Preliminary Findings.

answer: @entity7


abstract: Purpose: The American Society of Anesthesia practice guidelines recommend that pediatric and adult @entity0 who undergo ambulatory surgery be screened for @entity1 (OSA). With this in mind, our objective was to assess the frequency of screening by anesthesia providers for the signs and symptoms of OSA in @entity0 undergoing surgery in an ambulatory setting. Methods: Prospective single-blinded observational study of anesthesia providers' preoperative interview of caregivers of consecutive @entity0 younger than age 18 who were scheduled for ambulatory surgery. Results: One hundred one @entity0 (30 females) were identified, with a mean age of 6.9    5.0 years; 54 were classified as white, 33 as black, and 14 as other. Total OSA-18 scores ranged from 18 to 97, with a mean of 33.1    14.8. The mean score for adenotonsillectomy @entity0 was higher than that for @entity0 who underwent procedures other than adenotonsillectomy. Thirty-one percent of @entity0 were screened for OSA, and snoring was the most common symptom recorded (28%). @entity0 who were screened for OSA were more likely to have snoring (p < 0.001), known OSA (p = 0.006), and a scheduled adenotonsillectomy (p = 0.02). Conclusion: OSA was not routinely screened for by anesthesia providers prior to ambulatory pediatric surgery. When screening did occur, "snoring" was the most commonly recorded symptom. Paradoxically, @entity0 with undiagnosed OSA who would benefit the most from screening were the least likely to be screened. Commentary: A commentary on this article appears in this issue on page 697.

title: Screening for XXXX before Ambulatory Surgery.

answer: @entity1


abstract: @entity4 ( @entity4 ) of the shoulder is a rare disease. Here, we report two cases, with different destruction patterns, which were most probably due to @entity6 ( @entity6 ). Case 1 involved a 77-year-old @entity0 with right shoulder @entity1 . Rapid destruction of both the humeral head and glenoid was seen within 1 month of the onset of shoulder @entity1 . We diagnosed shoulder @entity4 and performed a hemiarthroplasty. Case 2 involved a 74-year-old @entity0 with left shoulder @entity1 . Humeral head collapse was seen within 5 months of @entity1 onset, without glenoid destruction. Magnetic resonance imaging showed a @entity3 pattern with an associated subchondral low-intensity band, typical of SIF. Total shoulder arthroplasty was performed in this case. Shoulder @entity4 occurs as a result of SIF in elderly @entity0 ; the progression of the joint destruction is more rapid in cases with @entity6 of both the humeral head and the glenoid. Although shoulder @entity4 is rare, this disease should be included in the differential diagnosis of acute onset shoulder @entity1 in elderly female @entity0 with @entity2 and @entity5 .

title: Rapid destruction of the humeral head caused by XXXX : a report of two cases.

answer: @entity6


abstract: The aim of the study was to test the performance of a new definition of @entity2 ( @entity2 ), which better describes metabolic dysfunction in @entity0 . Methods. 15,794 youths aged 6-18 years participated. Mean z-score for CVD risk factors was calculated. Sensitivity analyses were performed to evaluate which parameters best described the metabolic dysfunction by analysing the score against independent variables not included in the score. Results. More youth had clustering of CVD risk factors (>6.2%) compared to the number selected by existing @entity2 (International @entity1 Federation (IDF) < 1%). Waist circumference and BMI were interchangeable, but using insulin resistance homeostasis model assessment (HOMA) instead of fasting @entity4 increased the score. The continuous @entity2 score was increased when @entity3 ( @entity3 ) and leptin were included. A mean z-score of 0.40-0.85 indicated borderline and above 0.85 indicated clustering of risk factors. A noninvasive risk score based on adiposity and @entity3 showed sensitivity and specificity of 0.85 and an area under the curve of 0.92 against IDF definition of @entity2 . Conclusions. Diagnosis for @entity2 in youth can be improved by using continuous variables for risk factors and by including @entity3 and leptin.

title: A new approach to define and diagnose cardiometabolic disorder in XXXX .

answer: @entity0


abstract: Bioactive compounds from edible plants have limited efficacy in treating advanced @entity2 , but they have potential to increase the efficacy of chemotherapy drugs in a combined treatment. An aqueous extract of berries of Pimenta dioica (Allspice) shows promise as one such candidate for combination therapy or chemoprevention. An aqueous extract of Allspice (AAE) was tested against @entity1 @entity0 ( @entity0 ) cells in vitro and in vivo. AAE reduced the viability and clonogenic growth of several types of @entity0 cells (IC50  <= 100  g/ml) with limited @entity4 in non-tumorigenic, quiescent cells (IC50 >200  g/ml). AAE induced @entity4 in @entity0 was inconsistent with apoptosis, but was associated with increased levels of autophagy markers @entity8 and @entity8 -positive puncta. Silencing the expression of autophagy related genes (ATGs) prevented AAE-induced cell death. Further, AAE caused inhibition of @entity5 / @entity7 signaling, and showed enhanced @entity4 when combined with @entity6 , a chemotherapy drug and an inhibitor of @entity7 signaling. Oral administration (gavage) of AAE into athymic @entity3 implanted with @entity2 inhibited @entity2 growth slightly but not significantly (mean decrease ~ 14%, p >=  0.20) if @entity3 were gavaged post- @entity2 implant. @entity2 growth showed a significant delay (38%) in @entity2 palpability and growth rate (time to reach @entity2 volume >=  1,000 mm3) when @entity3 were pre-dosed with AAE for two weeks. Analysis of @entity2 tissues showed increased levels of @entity8 in AAE treated @entity2 , indicating elevated @entity2 cell death in vivo in treated @entity3 . These results demonstrate antitumor and chemo-preventive activity of AAE against @entity0 and potential for adjuvant to @entity7 inhibition.

title: Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills XXXX cells by autophagy and delays growth of @entity0 in athymic @entity3 .

answer: @entity0


abstract: Bioactive compounds from edible plants have limited efficacy in treating advanced @entity2 , but they have potential to increase the efficacy of chemotherapy drugs in a combined treatment. An aqueous extract of berries of Pimenta dioica (Allspice) shows promise as one such candidate for combination therapy or chemoprevention. An aqueous extract of Allspice (AAE) was tested against @entity1 @entity0 ( @entity0 ) cells in vitro and in vivo. AAE reduced the viability and clonogenic growth of several types of @entity0 cells (IC50  <= 100  g/ml) with limited @entity4 in non-tumorigenic, quiescent cells (IC50 >200  g/ml). AAE induced @entity4 in @entity0 was inconsistent with apoptosis, but was associated with increased levels of autophagy markers @entity8 and @entity8 -positive puncta. Silencing the expression of autophagy related genes (ATGs) prevented AAE-induced cell death. Further, AAE caused inhibition of @entity5 / @entity7 signaling, and showed enhanced @entity4 when combined with @entity6 , a chemotherapy drug and an inhibitor of @entity7 signaling. Oral administration (gavage) of AAE into athymic @entity3 implanted with @entity2 inhibited @entity2 growth slightly but not significantly (mean decrease ~ 14%, p >=  0.20) if @entity3 were gavaged post- @entity2 implant. @entity2 growth showed a significant delay (38%) in @entity2 palpability and growth rate (time to reach @entity2 volume >=  1,000 mm3) when @entity3 were pre-dosed with AAE for two weeks. Analysis of @entity2 tissues showed increased levels of @entity8 in AAE treated @entity2 , indicating elevated @entity2 cell death in vivo in treated @entity3 . These results demonstrate antitumor and chemo-preventive activity of AAE against @entity0 and potential for adjuvant to @entity7 inhibition.

title: Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills @entity0 cells by autophagy and delays growth of XXXX in athymic @entity3 .

answer: @entity0


abstract: Bioactive compounds from edible plants have limited efficacy in treating advanced @entity2 , but they have potential to increase the efficacy of chemotherapy drugs in a combined treatment. An aqueous extract of berries of Pimenta dioica (Allspice) shows promise as one such candidate for combination therapy or chemoprevention. An aqueous extract of Allspice (AAE) was tested against @entity1 @entity0 ( @entity0 ) cells in vitro and in vivo. AAE reduced the viability and clonogenic growth of several types of @entity0 cells (IC50  <= 100  g/ml) with limited @entity4 in non-tumorigenic, quiescent cells (IC50 >200  g/ml). AAE induced @entity4 in @entity0 was inconsistent with apoptosis, but was associated with increased levels of autophagy markers @entity8 and @entity8 -positive puncta. Silencing the expression of autophagy related genes (ATGs) prevented AAE-induced cell death. Further, AAE caused inhibition of @entity5 / @entity7 signaling, and showed enhanced @entity4 when combined with @entity6 , a chemotherapy drug and an inhibitor of @entity7 signaling. Oral administration (gavage) of AAE into athymic @entity3 implanted with @entity2 inhibited @entity2 growth slightly but not significantly (mean decrease ~ 14%, p >=  0.20) if @entity3 were gavaged post- @entity2 implant. @entity2 growth showed a significant delay (38%) in @entity2 palpability and growth rate (time to reach @entity2 volume >=  1,000 mm3) when @entity3 were pre-dosed with AAE for two weeks. Analysis of @entity2 tissues showed increased levels of @entity8 in AAE treated @entity2 , indicating elevated @entity2 cell death in vivo in treated @entity3 . These results demonstrate antitumor and chemo-preventive activity of AAE against @entity0 and potential for adjuvant to @entity7 inhibition.

title: Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills @entity0 cells by autophagy and delays growth of @entity0 in athymic XXXX .

answer: @entity3


abstract: The aim of this study was to triage platelet reactivity and adverse vascular outcomes after dual antiplatelet therapy due to percutaneous coronary intervention (PCI) dependent on @entity9 *2 and @entity9 *3 genotypes in @entity0 with @entity3 . Fifty-five @entity0 with @entity3 were studied serially pre-PCI and post-PCI. Platelet reactivity was assessed by conventional light transmission aggregometry, VerifyNow Analyzer, and thromboelastography with platelet mapping. Genetic testing was performed with allele-specific real-time polymerase chain reaction. Adverse events included @entity1 , acute @entity4 , repeated PCI, definite stent @entity5 , and @entity6 . The common genotype (GG) was found in 39 @entity0 , heterozygous polymorphism @entity9 (GA) @entity10 allele was detected in 14 @entity0 , and the rare homozygous polymorphism @entity9 (AA) @entity10 allele was exhibited in 2 @entity0 . There were no @entity9 *3 ( @entity11 ) carriers among index @entity0 . The platelet reactivity was higher in @entity0 with heterozygous and homozygous carriers compared with GG genotype. The largest differences were observed among GG, GA, and AA genotypes, which correlated with the average values of @entity8 (P = 0.02). There was a significant link between adverse events and high platelet reactivity assessed by light transmission aggregometry (P = 0.002). We found a trend between different genotype and VerifyNow readings (P = 0.057); moreover, their cumulative impact on adverse events was significant (P = 0.041). Platelet reactivity is higher in @entity0 with heterozygous and homozygous carriers of @entity9 *2 versus common genotype and may predict an increased risk of @entity7 response variability and/or experiencing adverse @entity2 .

title: XXXX response variability: impact of genetic polymorphism and platelet biomarkers for predicting adverse outcomes poststenting.

answer: @entity7


abstract: BACKGROUND: Intramedullary spinal @entity4 are @entity1 . OBJECTIVE: To provide a large retrospective review in the modern neuroimaging era from a tertiary center where aggressive surgical resection is favored. METHODS: Charts of intramedullary spinal @entity4 treated between 1983 and 2006 were reviewed. RESULTS: Sixty-seven cases were reviewed. The mean age was 45.6 years (range, 11-78 years) with a male-to-female ratio of 2:1. The most common location was the cervical spine, followed by the thoracic and lumbar spine. The average duration of symptoms was 33 months, with the most common symptom being @entity3 , followed by @entity5 , @entity7 , and urinary or sexual symptoms. Gross total resection was achieved in 55 @entity0 and a subtotal resection was performed in 12 @entity0 ; 9 @entity0 were treated with adjuvant radiation therapy. Mean follow-up was 32 months. The mean McCormick neurological grade at last follow-up was 2.0. The preoperative outcome correlated significantly with postoperative outcome (P < .001). A significant number of @entity0 who initially worsened improved at their 3-month follow-up examination. Outcomes were significantly worse in @entity0 undergoing subtotal resection with or without radiation therapy (P < .05). There were 3 recurrences. The overall complication rate was 34%. The primary complications were @entity8 or @entity9 . CONCLUSION: Spinal @entity6 are @entity2 to treat. Aggressive surgical resection is associated with a high overall complication rate. However, when gross total resection can be achieved, overall outcomes are excellent and the recurrence rate is low.

title: Surgical technique and outcomes in the treatment of spinal XXXX , part 1: @entity4 .

answer: @entity6


abstract: BACKGROUND: Intramedullary spinal @entity4 are @entity1 . OBJECTIVE: To provide a large retrospective review in the modern neuroimaging era from a tertiary center where aggressive surgical resection is favored. METHODS: Charts of intramedullary spinal @entity4 treated between 1983 and 2006 were reviewed. RESULTS: Sixty-seven cases were reviewed. The mean age was 45.6 years (range, 11-78 years) with a male-to-female ratio of 2:1. The most common location was the cervical spine, followed by the thoracic and lumbar spine. The average duration of symptoms was 33 months, with the most common symptom being @entity3 , followed by @entity5 , @entity7 , and urinary or sexual symptoms. Gross total resection was achieved in 55 @entity0 and a subtotal resection was performed in 12 @entity0 ; 9 @entity0 were treated with adjuvant radiation therapy. Mean follow-up was 32 months. The mean McCormick neurological grade at last follow-up was 2.0. The preoperative outcome correlated significantly with postoperative outcome (P < .001). A significant number of @entity0 who initially worsened improved at their 3-month follow-up examination. Outcomes were significantly worse in @entity0 undergoing subtotal resection with or without radiation therapy (P < .05). There were 3 recurrences. The overall complication rate was 34%. The primary complications were @entity8 or @entity9 . CONCLUSION: Spinal @entity6 are @entity2 to treat. Aggressive surgical resection is associated with a high overall complication rate. However, when gross total resection can be achieved, overall outcomes are excellent and the recurrence rate is low.

title: Surgical technique and outcomes in the treatment of spinal @entity6 , part 1: XXXX .

answer: @entity4


abstract: To obtain rates of mRNA synthesis and decay in @entity0 , we established dynamic transcriptome analysis ( @entity1 ). @entity1 combines non-perturbing metabolic RNA labeling with dynamic kinetic modeling. @entity1 reveals that most mRNA synthesis rates are around several transcripts per cell and cell cycle, and most mRNA half-lives range around a median of 11 min. @entity1 can monitor the cellular response to osmotic stress with higher sensitivity and temporal resolution than standard transcriptomics. In contrast to monotonically increasing total mRNA levels, @entity1 reveals three phases of the stress response. During the initial shock phase, mRNA synthesis and decay rates decrease globally, resulting in mRNA storage. During the subsequent induction phase, both rates increase for a subset of genes, resulting in production and rapid removal of stress-responsive mRNAs. During the recovery phase, decay rates are largely restored, whereas synthesis rates remain altered, apparently enabling growth at high salt concentration. Stress-induced changes in mRNA synthesis rates are predicted from gene occupancy with RNA polymerase II. @entity1 -derived mRNA synthesis rates identified 16 stress-specific pairs/triples of cooperative transcription factors, of which seven were known. Thus, @entity1 realistically monitors the dynamics in mRNA metabolism that underlie gene regulatory systems.

title: Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in XXXX .

answer: @entity0


abstract: BACKGROUND: Recent research has shown that most of the excess risk of @entity4 following breast and @entity3 in England compared with Norway and Sweden occurs in older age groups during the first year, and especially in the first month of follow-up. The aim of this study was to explore the characteristics of @entity1 dying within 30 days of being diagnosed with one of these @entity2 in Scotland during 2003-2007. METHODS: Anonymised @entity2 registry records linked to hospital discharge and @entity4 records were extracted. The study population was divided into @entity1 who died within 30 days of diagnosis (cases) and those who survived beyond this threshold (controls). Differences in @entity1 -, @entity2 -, and health service-related characteristics were assessed using the   (2)-test and logistic regression. RESULTS: @entity1 dying within 30 days were more likely to be elderly and to have experienced emergency admission to non-surgical specialities. Their @entity2 were less likely to have been verified microscopically, but they appeared more likely to be of high grade and advanced in stage. A substantial number of @entity1 died from causes other than their @entity2 . CONCLUSION: These results suggest that early mortality after a diagnosis of @entity0 may be partly due to comorbidity and lifestyle factors, as well as due to more @entity5 . Further research is required to determine the precise explanation for these findings and, in particular, if any potentially avoidable factors such as delays in presentation, referral, or diagnosis exist.

title: Characteristics of @entity1 dying within 30 days of diagnosis of XXXX in Scotland, 2003-2007.

answer: @entity0


abstract: BACKGROUND: Recent research has shown that most of the excess risk of @entity4 following breast and @entity3 in England compared with Norway and Sweden occurs in older age groups during the first year, and especially in the first month of follow-up. The aim of this study was to explore the characteristics of @entity1 dying within 30 days of being diagnosed with one of these @entity2 in Scotland during 2003-2007. METHODS: Anonymised @entity2 registry records linked to hospital discharge and @entity4 records were extracted. The study population was divided into @entity1 who died within 30 days of diagnosis (cases) and those who survived beyond this threshold (controls). Differences in @entity1 -, @entity2 -, and health service-related characteristics were assessed using the   (2)-test and logistic regression. RESULTS: @entity1 dying within 30 days were more likely to be elderly and to have experienced emergency admission to non-surgical specialities. Their @entity2 were less likely to have been verified microscopically, but they appeared more likely to be of high grade and advanced in stage. A substantial number of @entity1 died from causes other than their @entity2 . CONCLUSION: These results suggest that early mortality after a diagnosis of @entity0 may be partly due to comorbidity and lifestyle factors, as well as due to more @entity5 . Further research is required to determine the precise explanation for these findings and, in particular, if any potentially avoidable factors such as delays in presentation, referral, or diagnosis exist.

title: Characteristics of XXXX dying within 30 days of diagnosis of @entity0 in Scotland, 2003-2007.

answer: @entity1


abstract: BACKGROUND: With increasing laparoscopic surgery experience and improved new vessel-sealing equipment, @entity1 ( @entity1 ) for splenectomy has emerged as an alternative to multiport laparoscopy, but the application of @entity1 for @entity2 is still challenging due to technical difficulties. The aim of this study was to describe the suture suspension technique contributing to @entity1 for @entity4 ( @entity4 ). MATERIALS AND METHODS: A retrospective review was conducted to evaluate all @entity1 for @entity2 performed by a single surgeon. On preoperative ultrasonography, the spleen size index ranged from 0.67 to 0.82. An umbilical incision was used for the placement of a multichannel single port. To provide excellent exposure of the splenic hilum, a needle with a 1-0 suture was percutaneously introduced from the left hypochondriac region and then penetrated out the anterior chest wall for suspending the enlarged spleen. Dissection was facilitated by the use of a 5-mm curved reusable grasper and a 5-mm Harmonic(  ) scalpel (Ethicon Endo-Surgery, Cincinnati, @entity3 ), and the splenic vessels were ligated with 5-mm Weck(  ) Hem-o-lok(  ) clips (Teleflex(  ), Morrisville, NC). The resected spleen was placed in an endosurgical bag, morcellated, and removed from the abdomen via the umbilical incision. RESULTS: Nine @entity0 underwent @entity1 during the study period without conversion to open procedures or requiring additional ports. The suture suspension technique was successfully used and markedly improved the exposure of the splenic hilum. The operative time was 122.6  31.2 minutes, and the extracted spleen weight was 562  74.5   g (range, 420-1260   g). No intraoperative or postoperative complications were recorded. The umbilical incision healed well with a satisfactory cosmetic effect. CONCLUSIONS: Our outcome shows the suture suspension enables safe and feasible usage of @entity1 for the management of @entity2 in @entity0 with @entity4 . More experience is needed to assess advantages and disadvantages compared with the standard laparoscopic approach.

title: Single-Incision Laparoscopic Splenectomy Using the Suture Suspension Technique for XXXX in @entity0 with @entity4 .

answer: @entity2


abstract: BACKGROUND: With increasing laparoscopic surgery experience and improved new vessel-sealing equipment, @entity1 ( @entity1 ) for splenectomy has emerged as an alternative to multiport laparoscopy, but the application of @entity1 for @entity2 is still challenging due to technical difficulties. The aim of this study was to describe the suture suspension technique contributing to @entity1 for @entity4 ( @entity4 ). MATERIALS AND METHODS: A retrospective review was conducted to evaluate all @entity1 for @entity2 performed by a single surgeon. On preoperative ultrasonography, the spleen size index ranged from 0.67 to 0.82. An umbilical incision was used for the placement of a multichannel single port. To provide excellent exposure of the splenic hilum, a needle with a 1-0 suture was percutaneously introduced from the left hypochondriac region and then penetrated out the anterior chest wall for suspending the enlarged spleen. Dissection was facilitated by the use of a 5-mm curved reusable grasper and a 5-mm Harmonic(  ) scalpel (Ethicon Endo-Surgery, Cincinnati, @entity3 ), and the splenic vessels were ligated with 5-mm Weck(  ) Hem-o-lok(  ) clips (Teleflex(  ), Morrisville, NC). The resected spleen was placed in an endosurgical bag, morcellated, and removed from the abdomen via the umbilical incision. RESULTS: Nine @entity0 underwent @entity1 during the study period without conversion to open procedures or requiring additional ports. The suture suspension technique was successfully used and markedly improved the exposure of the splenic hilum. The operative time was 122.6  31.2 minutes, and the extracted spleen weight was 562  74.5   g (range, 420-1260   g). No intraoperative or postoperative complications were recorded. The umbilical incision healed well with a satisfactory cosmetic effect. CONCLUSIONS: Our outcome shows the suture suspension enables safe and feasible usage of @entity1 for the management of @entity2 in @entity0 with @entity4 . More experience is needed to assess advantages and disadvantages compared with the standard laparoscopic approach.

title: Single-Incision Laparoscopic Splenectomy Using the Suture Suspension Technique for @entity2 in @entity0 with XXXX .

answer: @entity4


abstract: BACKGROUND: With increasing laparoscopic surgery experience and improved new vessel-sealing equipment, @entity1 ( @entity1 ) for splenectomy has emerged as an alternative to multiport laparoscopy, but the application of @entity1 for @entity2 is still challenging due to technical difficulties. The aim of this study was to describe the suture suspension technique contributing to @entity1 for @entity4 ( @entity4 ). MATERIALS AND METHODS: A retrospective review was conducted to evaluate all @entity1 for @entity2 performed by a single surgeon. On preoperative ultrasonography, the spleen size index ranged from 0.67 to 0.82. An umbilical incision was used for the placement of a multichannel single port. To provide excellent exposure of the splenic hilum, a needle with a 1-0 suture was percutaneously introduced from the left hypochondriac region and then penetrated out the anterior chest wall for suspending the enlarged spleen. Dissection was facilitated by the use of a 5-mm curved reusable grasper and a 5-mm Harmonic(  ) scalpel (Ethicon Endo-Surgery, Cincinnati, @entity3 ), and the splenic vessels were ligated with 5-mm Weck(  ) Hem-o-lok(  ) clips (Teleflex(  ), Morrisville, NC). The resected spleen was placed in an endosurgical bag, morcellated, and removed from the abdomen via the umbilical incision. RESULTS: Nine @entity0 underwent @entity1 during the study period without conversion to open procedures or requiring additional ports. The suture suspension technique was successfully used and markedly improved the exposure of the splenic hilum. The operative time was 122.6  31.2 minutes, and the extracted spleen weight was 562  74.5   g (range, 420-1260   g). No intraoperative or postoperative complications were recorded. The umbilical incision healed well with a satisfactory cosmetic effect. CONCLUSIONS: Our outcome shows the suture suspension enables safe and feasible usage of @entity1 for the management of @entity2 in @entity0 with @entity4 . More experience is needed to assess advantages and disadvantages compared with the standard laparoscopic approach.

title: Single-Incision Laparoscopic Splenectomy Using the Suture Suspension Technique for @entity2 in XXXX with @entity4 .

answer: @entity0


abstract: A 63-year-old @entity0 with @entity2 was referred to our hospital. Her pancreatic enzymes were elevated, and an abdominal computed tomography (CT) scan showed an enlarged pancreas, consistent with @entity3 , and gas collection containing an impacted stone adjacent to @entity5 . This finding raised the suspicion of a duodenal diverticulum. A subsequent ERCP showed a juxtapapillary duodenal diverticulum (JPDD) filled with calculi and pus. The @entity3 improved with 2 weeks of conservative treatment. Subsequently, the @entity0 underwent resection of the uterus and bilateral adnexa to remove a large @entity1 that was also identified on the admission CT scan. On the third postoperative day, she developed @entity2 . CT revealed @entity4 caused by an enterolith expelled from JPDD. Enterotomy was performed to remove the stone. To our knowledge, only three similar cases have been previously reported in Japan.

title: A case of enterolith ileus secondary to acute XXXX associated with a juxtapapillary duodenal diverticulum.

answer: @entity3


abstract: @entity2 is caused by the tapeworm @entity6 and it is an endemic @entity4 disease of the Mediterranean countries. Although the liver is the most involved organ by this disease, @entity5 can be found anywhere in the @entity0 body. Rare forms of location may pose diagnostic and therapeutic dilemmas. Herein we report our experience with unusual located hydatid disease diagnosed and treated at our center the last 33 years. A total of 233 @entity0 were treated for @entity5 (91 males: 39% and 142 females: 61%) between 1980 and 2013 at our center. 18 of them (7, 8%) with uncommon located hydatid disease, were analyzed retrospectively. 18 @entity0 (8 males and 10 females) were presented with unusual location of hydatid disease in our series. Two of them had only extrahepatic cysts (0, 9%). A total of 64 hydatid cysts with unusual location were analyzed. The most prevalent extrahepatic sites were peritoneal cavity and spleen. Total cystectomy with or without tube drainage or omentopexy was performed for hydatid cysts of the peritoneal cavity in our series. Splenectomy was performed in all cases of @entity5 . The mean time of post operative stay was 16, 3 days (range 7-35 days), morbidity 11% and mortality 5, 4%. Although @entity5 is found most often in the liver and lungs, it seems that any organ can be involved by this zoonotic disease. The operating surgeon must always consider the possibility of unusual location of @entity1 when dealing with @entity0 with @entity3 in endemic areas, because any misinterpretation may result in unfavorable outcomes.

title: Unusual locations of hydatid disease: a 33  year's experience analysis on 233 XXXX .

answer: @entity0


abstract: BACKGROUND: To investigate the efficacy and safety of adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver in partial hepatectomy for @entity1 . MATERIALS AND METHODS: This is a retrospective study on data that were prospectively collected and entered into a computer database. A total of 36 @entity0 who underwent partial hepatectomy for @entity3 by adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver at a tertiary care university hospital were compared with a historical case-matched control group of 36 @entity0 who received intermittent Pringle maneuver only. RESULTS: The @entity0 characteristics were comparable for the 2 groups of @entity0 . The mean hepatic artery occlusion time was 58  min (range 36-98  min). Intraoperative @entity2 and blood transfusion rate in the study group were significantly lower than the control group (P  <  .001 and P  =  .004, respectively). There were no significant differences in the postoperative serum @entity4 transaminase and total @entity5 levels (P  =  .087, P  =  .135, respectively), and in the postoperative hospital stay and surgical complications according to Clavien's classification between the two groups (P  =  0.213, P  =  1.000, respectively). The disease-free survival rates in the study group was significantly better than the control group (P  =  .023). Overall, @entity1 @entity0 with @entity3 had poor prognosis. CONCLUSIONS: The addition of continuous occlusion of hepatic artery proper to intermittent Pringle maneuver significantly reduced intraoperative @entity2 for partial hepatectomy in @entity0 with @entity3 when compared with intermittent Pringle maneuver alone. The procedure was found to be safe even for @entity0 with @entity6 .

title: Continuous occlusion of hepatic artery proper for prevention of XXXX in partial hepatectomy for @entity1 : a case-matched comparative study.

answer: @entity2


abstract: BACKGROUND: To investigate the efficacy and safety of adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver in partial hepatectomy for @entity1 . MATERIALS AND METHODS: This is a retrospective study on data that were prospectively collected and entered into a computer database. A total of 36 @entity0 who underwent partial hepatectomy for @entity3 by adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver at a tertiary care university hospital were compared with a historical case-matched control group of 36 @entity0 who received intermittent Pringle maneuver only. RESULTS: The @entity0 characteristics were comparable for the 2 groups of @entity0 . The mean hepatic artery occlusion time was 58  min (range 36-98  min). Intraoperative @entity2 and blood transfusion rate in the study group were significantly lower than the control group (P  <  .001 and P  =  .004, respectively). There were no significant differences in the postoperative serum @entity4 transaminase and total @entity5 levels (P  =  .087, P  =  .135, respectively), and in the postoperative hospital stay and surgical complications according to Clavien's classification between the two groups (P  =  0.213, P  =  1.000, respectively). The disease-free survival rates in the study group was significantly better than the control group (P  =  .023). Overall, @entity1 @entity0 with @entity3 had poor prognosis. CONCLUSIONS: The addition of continuous occlusion of hepatic artery proper to intermittent Pringle maneuver significantly reduced intraoperative @entity2 for partial hepatectomy in @entity0 with @entity3 when compared with intermittent Pringle maneuver alone. The procedure was found to be safe even for @entity0 with @entity6 .

title: Continuous occlusion of hepatic artery proper for prevention of @entity2 in partial hepatectomy for XXXX : a case-matched comparative study.

answer: @entity1


abstract: UNASSIGNED: Calcification is a rare phenomenon in high grade @entity2 (HGG). CT scans are sensitive to mineralization but used infrequently for @entity1 assessment in the MRI era. The presence of @entity6 can be overlooked on routine MRI. Calcification may reflect chronicity and natural changes in the @entity1 or its milieu over time and may be accelerated by certain treatments. Calcification may have clinical significance which could signal potential risk for @entity3 or @entity5 related to particular therapies; or it may be a positive prognostic factor for treatment response. The true incidence and relevance of @entity6 in HGG and relation to therapy is unclear. During treatment of HGG @entity0 with bevacizumab (BVZ) we observed significant @entity1 @entity6 on brain CT. We performed a retrospective review of HGG @entity0 treated with BVZ to quantitate the incidence of @entity6 in this group compared to those treated with cytotoxic therapy alone. Sixty-two @entity0 with progressive HGG were treated with BVZ and a cytotoxic agent. Among 19 @entity0 treated for 6+ months, 12 had a CT scan performed. We observed an unexpected phenomenon of @entity6 in the CT scans of several @entity0 . We were also able to comparatively quantitate the incidence of @entity6 in a control group of @entity4 (GB) @entity0 not exposed to BVZ therapy. The incidence of @entity6 in the general GB population is increased with longer survival. The phenomenon is increased with anti-angiogenic therapy for @entity7 . Calcification may have significance as a predictor for treatment response.

title: Calcification in high grade XXXX treated with bevacizumab.

answer: @entity2


abstract: BACKGROUND: @entity2 immune globulin (HBIg) in combination with a nucleos(t)ide analog is the mainstay of prophylactic regimen to prevent recurrence of @entity2 following orthotopic liver transplantation (OLT). HBIg therapy is costly and inconvenient for the @entity0 . There is a growing experience converting HBIg/nucleos(t)ide to combination @entity3 / @entity4 analogs from. METHODS: Twenty-six @entity0 that underwent OLT between March 2001 and July 2011 who had received at least 12  months of HBIg and single nucleos(t)ide were enrolled. HBsAg and @entity1 DNA were undetectable, and anti-HBs were detectable at the time of switch. @entity1 DNA and @entity5 were measured every 3  months following discontinuation of HBIg and addition of nucleos(t)ide. RESULTS: @entity0 included 23 Asians/3 Caucasian, 21 males/5 females. Mean time of conversion from HBIg/nucleos(t)ide to @entity4 / @entity3 combination was 77.5 (range 11-132) months after OLT. Mean duration of follow-up after conversion was 31.9 (range 14-70) months. All @entity0 had undetectable @entity1 DNA, and 24 @entity0 remained HBsAg negative during follow-up. Two @entity0 recurred 7 and 9  months later, respectively, with detectable HBsAg. Both @entity0 continued to have undetectable @entity1 DNA and normal ALT. HBsAg was neutralized by reinfusion of HBIg. CONCLUSION: @entity4 / @entity3 combination is an effective alternative to HBIg/nucleos(t)ide to prevent recurrence of @entity2 after OLT.

title: @entity4 - XXXX Analog Combination Therapy Is Effective in Preventing Recurrent @entity2 After Liver Transplantation.

answer: @entity3


abstract: BACKGROUND: @entity2 immune globulin (HBIg) in combination with a nucleos(t)ide analog is the mainstay of prophylactic regimen to prevent recurrence of @entity2 following orthotopic liver transplantation (OLT). HBIg therapy is costly and inconvenient for the @entity0 . There is a growing experience converting HBIg/nucleos(t)ide to combination @entity3 / @entity4 analogs from. METHODS: Twenty-six @entity0 that underwent OLT between March 2001 and July 2011 who had received at least 12  months of HBIg and single nucleos(t)ide were enrolled. HBsAg and @entity1 DNA were undetectable, and anti-HBs were detectable at the time of switch. @entity1 DNA and @entity5 were measured every 3  months following discontinuation of HBIg and addition of nucleos(t)ide. RESULTS: @entity0 included 23 Asians/3 Caucasian, 21 males/5 females. Mean time of conversion from HBIg/nucleos(t)ide to @entity4 / @entity3 combination was 77.5 (range 11-132) months after OLT. Mean duration of follow-up after conversion was 31.9 (range 14-70) months. All @entity0 had undetectable @entity1 DNA, and 24 @entity0 remained HBsAg negative during follow-up. Two @entity0 recurred 7 and 9  months later, respectively, with detectable HBsAg. Both @entity0 continued to have undetectable @entity1 DNA and normal ALT. HBsAg was neutralized by reinfusion of HBIg. CONCLUSION: @entity4 / @entity3 combination is an effective alternative to HBIg/nucleos(t)ide to prevent recurrence of @entity2 after OLT.

title: XXXX - @entity3 Analog Combination Therapy Is Effective in Preventing Recurrent @entity2 After Liver Transplantation.

answer: @entity4


abstract: BACKGROUND: @entity2 immune globulin (HBIg) in combination with a nucleos(t)ide analog is the mainstay of prophylactic regimen to prevent recurrence of @entity2 following orthotopic liver transplantation (OLT). HBIg therapy is costly and inconvenient for the @entity0 . There is a growing experience converting HBIg/nucleos(t)ide to combination @entity3 / @entity4 analogs from. METHODS: Twenty-six @entity0 that underwent OLT between March 2001 and July 2011 who had received at least 12  months of HBIg and single nucleos(t)ide were enrolled. HBsAg and @entity1 DNA were undetectable, and anti-HBs were detectable at the time of switch. @entity1 DNA and @entity5 were measured every 3  months following discontinuation of HBIg and addition of nucleos(t)ide. RESULTS: @entity0 included 23 Asians/3 Caucasian, 21 males/5 females. Mean time of conversion from HBIg/nucleos(t)ide to @entity4 / @entity3 combination was 77.5 (range 11-132) months after OLT. Mean duration of follow-up after conversion was 31.9 (range 14-70) months. All @entity0 had undetectable @entity1 DNA, and 24 @entity0 remained HBsAg negative during follow-up. Two @entity0 recurred 7 and 9  months later, respectively, with detectable HBsAg. Both @entity0 continued to have undetectable @entity1 DNA and normal ALT. HBsAg was neutralized by reinfusion of HBIg. CONCLUSION: @entity4 / @entity3 combination is an effective alternative to HBIg/nucleos(t)ide to prevent recurrence of @entity2 after OLT.

title: @entity4 - @entity3 Analog Combination Therapy Is Effective in Preventing Recurrent XXXX After Liver Transplantation.

answer: @entity2


abstract: PURPOSE: To identify and highlight the variable causes of @entity14 . METHOD: Literature review. RESULTS: Camptocormia ( @entity14 ) is an acquired postural disease characterised by forward flexion of the thoraco-lumbar spine. Camptocormia leads to lumbar kyphosis and increases during walking or standing and completely disappears in supine position. Camptocormia is multicausal due to central or @entity13 , @entity16 or due to some rare conditions. Camptocormia is most frequently associated with @entity6 . Other causes include @entity15 , @entity19 , @entity7 , @entity3 , @entity18 , @entity12 or chronic inflammatory demyelinating @entity8 . Rare causes include adverse reactions of drugs, disc @entity17 , @entity9 , @entity11 , @entity2 , or @entity5 disease (more rarely than previously thought). Camptocormia is diagnosed upon clinical investigations, imaging of the cerebrum or spine, electromyography or muscle biopsy. Treatment is limited on supportive conservative measures, to withdrawal of causative drugs, electroconvulsive therapy, surgical correction or deep brain stimulation and effective only in single @entity0 . CONCLUSIONS: Camptocormia is organic in the vast majority of the cases due to @entity1 , or rarely drugs, @entity4 , @entity10 or @entity16 .

title: Causes of XXXX .

answer: @entity14


abstract: By regulating the timing of cellular processes, the circadian clock provides a way to adapt physiology and behaviour to the geophysical time. In mammals, a light-entrainable master clock located in the @entity6 ( @entity6 ) controls peripheral clocks that are present in virtually every body cell. Defective circadian timing is associated with several pathologies such as @entity2 and @entity3 . To better understand the circadian regulation of cellular processes, we developed a bioinformatics pipeline encompassing the analysis of high-throughput data sets and the exploitation of published knowledge by text-mining. We identified 118 novel potential clock-regulated genes and integrated them into an existing high-quality circadian network, generating the to-date most comprehensive network of circadian regulated genes (NCRG). To validate particular elements in our network, we assessed publicly available ChIP-seq data for @entity5 , REV-ERBa/b and @entity9 /y proteins and found strong evidence for circadian regulation of @entity7 , @entity8 , Dhx6, @entity10 and @entity12 all of which are involved in the regulation of tumourigenesis. Furthermore, we identified @entity4 and @entity11 , as targets of RORy and REV-ERBa, b, respectively. Most interestingly, these genes were also reported to be involved in miRNA regulation; in particular, @entity4 regulates several miRNAs, all involved in @entity2 . Thus, @entity4 represents a novel potential link via which the circadian clock, and specifically RORy, regulates the expression of miRNAs, with particular consequences in @entity0 progression. Our findings bring us one step forward towards a mechanistic understanding of @entity1 circadian regulation, and provide further evidence of the influence of circadian deregulation in @entity2 .

title: Assembly of a comprehensive regulatory network for the XXXX circadian clock: a bioinformatics approach.

answer: @entity1


abstract: AIMS: We investigated the interaction between magnetic @entity2 nanotubes (CNTs) and mesenchymal stem cells (MSCs), and their ability to guide these intravenously injected cells in living @entity0 by using an external magnetic field. MATERIALS _ METHODS: Multiwalled CNTs were used to treat MSCs derived from @entity0 bone marrow. @entity1 induced by nanotubes was studied using the WST-1 proliferation and Hoechest 33258 apoptosis assays. The effects of nanotubes on MSCs were evaluated by monitoring the effects on cellular growth rates, immunophenotyping and differentiation, and on the arrangement of cytoskeletal actin. MSCs loaded with nanotubes were injected in vivo in the portal vein of @entity0 driving their localization in the liver by magnetic field. An histological analysis was performed on the liver, lungs and kidneys of all animals. RESULTS: CNTs did not affect cell viability and their ability to differentiate in osteocytes and adipocytes. Both the CNTs and the magnetic field did not alter the cell growth rate, phenotype and cytoskeletal conformation. CNTs, when exposed to magnetic fields, are able to shepherd MSCs towards the magnetic source in vitro. Moreover, the application of a magnetic field alters the biodistribution of CNT-labelled MSCs after intravenous injection into @entity0 , increasing the accumulation of cells into the target organ (liver). CONCLUSION: Multiwalled CNTs hold the potential for use as nanodevices to improve therapeutic protocols for transplantation and homing of stem cells in vivo. This could pave the way for the development of new strategies for the manipulation/guidance of MSCs in regenerative medicine and cell transplantation.

title: Magnetic XXXX nanotubes: a new tool for shepherding mesenchymal stem cells by magnetic fields.

answer: @entity2


abstract: UNASSIGNED: Power ultrasound reduces the traditional @entity2 steeping time from 18 to 1.5 h during tortilla chips dough (masa) processing. This study sought to examine consumer (n = 99) acceptability and quality of tortilla chips made from the masa by traditional compared with ultrasonic methods. Overall appearance, flavor, and texture acceptability scores were evaluated using a 9-point hedonic scale. The baked chips (process intermediate) before and after frying (finished product) were analyzed using a texture analyzer and machine vision. The texture values were determined using the 3-point bend test using breaking force gradient (BFG), peak breaking force (PBF), and breaking distance (BD). The fracturing properties determined by the crisp @entity0 support rig using @entity0 force gradient (FFG), peak @entity0 force (PFF), and @entity0 ( @entity0 ). The machine vision evaluated the total surface area, lightness (L), color difference (  E), Hue (  h), and @entity1 (C*). The results were evaluated by analysis of variance and means were separated using Tukey's test. Machine vision values of L,   h, were higher (P < 0.05) and   E was lower (P < 0.05) for fried and L,   h were significantly (P < 0.05) higher for baked chips produced from ultra-sonication as compare to traditional. Baked chips texture for ultra-sonication was significantly higher (P < 0.05) on BFG, BPD, PFF, and @entity0 . Fried tortilla chips texture were higher significantly (P < 0.05) in BFG and PFF for ultra-sonication than traditional processing. However, the instrumental differences were not detected in sensory analysis, concluding possibility of power ultrasound as potential tortilla chips processing aid.

title: Sensory and Quality Evaluation of Traditional Compared with Power Ultrasound Processed XXXX (Zea Mays) Tortilla Chips.

answer: @entity2


abstract: PURPOSE: Rolapitant is a novel, long-acting @entity9 ( @entity10 antagonist. This study evaluated the safety and efficacy of four different doses of rolapitant for prevention of chemotherapy-induced @entity6 (CINV) due to highly emetogenic chemotherapy (HEC). METHODS: This randomized, double-blind, active-controlled, global study was conducted in @entity0 receiving @entity4 -based chemotherapy >= 70  mg/m(2). @entity0 received a 9, 22.5, 90, or 180  mg oral dose of rolapitant or placebo with ondansetron and @entity3 on day 1 of chemotherapy. The primary end point was complete response (CR; no emesis and no use of rescue medication) in the overall (0 to 120  h) phase of cycle 1. Other assessments were CR in delayed (24-120  h) and acute (0-24  h) phases, no emesis, no significant @entity2 , and no @entity2 . RESULTS: Four hundred fifty-four @entity0 were randomized. All doses of rolapitant improved CR with the greatest benefit observed with rolapitant 180  mg vs. active control in the overall phase (62.5 and 46.7  %, p   =   0.032) and in the acute (87.6 vs. 66.7  %, p   =   0.001) and delayed (63.6 vs. 48.9  %, p   =   0.045) phases. Rates for no emesis and no significant @entity2 were significantly (p   <   0.05) higher with rolapitant 180  mg vs. active control in the overall, acute, and delayed phases. Treatment-related adverse events were largely considered related to the chemotherapy and included @entity5 , @entity1 , @entity7 , and @entity8 which were mostly mild or moderate and were similar across treatment groups. CONCLUSION: All doses of rolapitant were well tolerated and showed greater CR rates than active control. @entity11 180  mg demonstrated significant clinical efficacy for preventing CINV in the overall, delayed, and acute phases for @entity0 receiving HEC.

title: Study of rolapitant, a novel, long-acting, @entity10 antagonist, for the prevention of chemotherapy-induced XXXX (CINV) due to highly emetogenic chemotherapy (HEC).

answer: @entity6


abstract: PURPOSE: Rolapitant is a novel, long-acting @entity9 ( @entity10 antagonist. This study evaluated the safety and efficacy of four different doses of rolapitant for prevention of chemotherapy-induced @entity6 (CINV) due to highly emetogenic chemotherapy (HEC). METHODS: This randomized, double-blind, active-controlled, global study was conducted in @entity0 receiving @entity4 -based chemotherapy >= 70  mg/m(2). @entity0 received a 9, 22.5, 90, or 180  mg oral dose of rolapitant or placebo with ondansetron and @entity3 on day 1 of chemotherapy. The primary end point was complete response (CR; no emesis and no use of rescue medication) in the overall (0 to 120  h) phase of cycle 1. Other assessments were CR in delayed (24-120  h) and acute (0-24  h) phases, no emesis, no significant @entity2 , and no @entity2 . RESULTS: Four hundred fifty-four @entity0 were randomized. All doses of rolapitant improved CR with the greatest benefit observed with rolapitant 180  mg vs. active control in the overall phase (62.5 and 46.7  %, p   =   0.032) and in the acute (87.6 vs. 66.7  %, p   =   0.001) and delayed (63.6 vs. 48.9  %, p   =   0.045) phases. Rates for no emesis and no significant @entity2 were significantly (p   <   0.05) higher with rolapitant 180  mg vs. active control in the overall, acute, and delayed phases. Treatment-related adverse events were largely considered related to the chemotherapy and included @entity5 , @entity1 , @entity7 , and @entity8 which were mostly mild or moderate and were similar across treatment groups. CONCLUSION: All doses of rolapitant were well tolerated and showed greater CR rates than active control. @entity11 180  mg demonstrated significant clinical efficacy for preventing CINV in the overall, delayed, and acute phases for @entity0 receiving HEC.

title: Study of rolapitant, a novel, long-acting, XXXX antagonist, for the prevention of chemotherapy-induced @entity6 (CINV) due to highly emetogenic chemotherapy (HEC).

answer: @entity10


abstract: OBJECTIVES: To assess the feasibility of a novel diagnostic algorithm targeting @entity0 with risk factors for @entity4 in a community setting. DESIGN: Prospective cross-sectional study. SETTING: Two primary care practices (adult @entity0 population 10   479) in Nottingham, UK. @entity0 : Adult @entity0 (aged 18   years or over) fulfilling one or more selected risk factors for developing @entity4 : (1) hazardous @entity3 use, (2) type 2 @entity1 or (3) persistently elevated @entity6 aminotransferase (ALT) liver function enzyme with negative serology. INTERVENTIONS: A serial biomarker algorithm, using a simple blood-based marker ( @entity7 aminotransferase:ALT ratio for hazardous @entity3 users, BARD score for other risk groups) and subsequently liver stiffness measurement using transient elastography (TE). MAIN OUTCOME MEASURES: Diagnosis of clinically significant @entity4 (defined as liver stiffness >= 8   kPa); definitive diagnosis of @entity5 . RESULTS: We identified 920 @entity0 with the defined risk factors of whom 504 @entity0 agreed to undergo investigation. A normal blood biomarker was found in 62 @entity0 (12.3%) who required no further investigation. Subsequently, 378 @entity0 agreed to undergo TE, of whom 98 (26.8% of valid scans) had elevated liver stiffness. Importantly, 71/98 (72.4%) @entity0 with elevated liver stiffness had normal liver enzymes and would be missed by traditional investigation algorithms. We identified 11 new @entity0 with definite @entity2 , representing a 140% increase in the number of diagnosed cases in this population. CONCLUSIONS: A non-invasive liver investigation algorithm based in a community setting is feasible to implement. Targeting risk factors using a non-invasive biomarker approach identified a substantial number of @entity0 with previously undetected @entity2 . TRIAL REGISTRATION NUMBER: The diagnostic algorithm utilised for this study can be found on clinicaltrials.gov (NCT02037867), and is part of a continuing longitudinal cohort study.

title: Direct targeting of risk factors significantly increases the detection of XXXX in primary care: a cross-sectional diagnostic study utilising transient elastography.

answer: @entity5


abstract: AIM: To investigate the dynamic changes and functions of @entity5 (UT) in pulmonary arteries of @entity0 chronically exposed to @entity3 - @entity4 . METHODS: In @entity0 with @entity3 - @entity4 at 1, 2 and 4 weeks @entity5 receptor binding of pulmonary arteries sarcolemma was determined by radioligand assay. @entity5 mRNA and UTmRNA in various grades of pulmonary arterioles were measured by in situ hybridization. RESULTS: (1) Mean pulmonary pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV + S) of 1-week group were higher than those of normal control (NC) group by 26.2% and 21.6% (P < 0.01), respectively, and 2-week group higher than 1-week group by 22.5% and 14.1% (respectively, P < 0.01). However, no significant changes were found between 4-week and 2-week group. (2) U Il receptor (Bmax) of 1-week group was higher than NC group by 38.8%, 2-week group higher than 1-week group by 23.2%, and 4-week group increased 7.3% compared with 2-week group (respectively, P < 0.01). The UT changes were time-dependent, while the affinity to @entity5 (Kd) was no different among each group. (3) @entity5 mRNA in each grade of pulmonary arterioles of 2-week group and 4-week group were higher than NC group (respectively, P < 0.01), and those of 2-week group were higher than 1-week group by 5.9% (P > 0.05), 16.4% and 9.1% (respectively, P < 0.01), while no differences existed between 2-week group and 4-week group. (4) UT mRNA in each grade of pulmonary arterioles of all @entity3 - @entity4 groups was higher than NC group (respectively, P < 0.01), and those of two abaxial grade vessels in 1-week group were the highest. No differences existed between 2-week group and 4-week group. (5) The pulmonary vessels remodeling were time-dependently aggravated by @entity3 - @entity4 . CONCLUSION: The dynamic changes of UT in pulmonary arterioles might have important contribution to the development of @entity1 and @entity2 remodeling induced by chronic @entity3 - @entity4 in @entity0 .

title: [Dynamic changes of urotensin II receptor in pulmonary artery and arterioles of @entity0 chronically exposed to XXXX - @entity4 ].

answer: @entity3


abstract: AIM: To investigate the dynamic changes and functions of @entity5 (UT) in pulmonary arteries of @entity0 chronically exposed to @entity3 - @entity4 . METHODS: In @entity0 with @entity3 - @entity4 at 1, 2 and 4 weeks @entity5 receptor binding of pulmonary arteries sarcolemma was determined by radioligand assay. @entity5 mRNA and UTmRNA in various grades of pulmonary arterioles were measured by in situ hybridization. RESULTS: (1) Mean pulmonary pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV + S) of 1-week group were higher than those of normal control (NC) group by 26.2% and 21.6% (P < 0.01), respectively, and 2-week group higher than 1-week group by 22.5% and 14.1% (respectively, P < 0.01). However, no significant changes were found between 4-week and 2-week group. (2) U Il receptor (Bmax) of 1-week group was higher than NC group by 38.8%, 2-week group higher than 1-week group by 23.2%, and 4-week group increased 7.3% compared with 2-week group (respectively, P < 0.01). The UT changes were time-dependent, while the affinity to @entity5 (Kd) was no different among each group. (3) @entity5 mRNA in each grade of pulmonary arterioles of 2-week group and 4-week group were higher than NC group (respectively, P < 0.01), and those of 2-week group were higher than 1-week group by 5.9% (P > 0.05), 16.4% and 9.1% (respectively, P < 0.01), while no differences existed between 2-week group and 4-week group. (4) UT mRNA in each grade of pulmonary arterioles of all @entity3 - @entity4 groups was higher than NC group (respectively, P < 0.01), and those of two abaxial grade vessels in 1-week group were the highest. No differences existed between 2-week group and 4-week group. (5) The pulmonary vessels remodeling were time-dependently aggravated by @entity3 - @entity4 . CONCLUSION: The dynamic changes of UT in pulmonary arterioles might have important contribution to the development of @entity1 and @entity2 remodeling induced by chronic @entity3 - @entity4 in @entity0 .

title: [Dynamic changes of urotensin II receptor in pulmonary artery and arterioles of @entity0 chronically exposed to @entity3 - XXXX ].

answer: @entity4


abstract: AIM: To investigate the dynamic changes and functions of @entity5 (UT) in pulmonary arteries of @entity0 chronically exposed to @entity3 - @entity4 . METHODS: In @entity0 with @entity3 - @entity4 at 1, 2 and 4 weeks @entity5 receptor binding of pulmonary arteries sarcolemma was determined by radioligand assay. @entity5 mRNA and UTmRNA in various grades of pulmonary arterioles were measured by in situ hybridization. RESULTS: (1) Mean pulmonary pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV + S) of 1-week group were higher than those of normal control (NC) group by 26.2% and 21.6% (P < 0.01), respectively, and 2-week group higher than 1-week group by 22.5% and 14.1% (respectively, P < 0.01). However, no significant changes were found between 4-week and 2-week group. (2) U Il receptor (Bmax) of 1-week group was higher than NC group by 38.8%, 2-week group higher than 1-week group by 23.2%, and 4-week group increased 7.3% compared with 2-week group (respectively, P < 0.01). The UT changes were time-dependent, while the affinity to @entity5 (Kd) was no different among each group. (3) @entity5 mRNA in each grade of pulmonary arterioles of 2-week group and 4-week group were higher than NC group (respectively, P < 0.01), and those of 2-week group were higher than 1-week group by 5.9% (P > 0.05), 16.4% and 9.1% (respectively, P < 0.01), while no differences existed between 2-week group and 4-week group. (4) UT mRNA in each grade of pulmonary arterioles of all @entity3 - @entity4 groups was higher than NC group (respectively, P < 0.01), and those of two abaxial grade vessels in 1-week group were the highest. No differences existed between 2-week group and 4-week group. (5) The pulmonary vessels remodeling were time-dependently aggravated by @entity3 - @entity4 . CONCLUSION: The dynamic changes of UT in pulmonary arterioles might have important contribution to the development of @entity1 and @entity2 remodeling induced by chronic @entity3 - @entity4 in @entity0 .

title: [Dynamic changes of urotensin II receptor in pulmonary artery and arterioles of XXXX chronically exposed to @entity3 - @entity4 ].

answer: @entity0


abstract: BACKGROUND AND OBJECTIVE: @entity0 with @entity2 , an abnormally short, thickened, or tight lingual frenulum, may have @entity1 mobility and sequelae, such as speech and feeding difficulties and social concerns. We systematically reviewed literature on feeding, speech, and social outcomes of treatments for @entity0 and @entity0 with @entity2 . METHODS: Medline, PsycINFO, Cumulative Index of Nursing and Allied Health Literature, and Embase were searched. Two reviewers independently assessed studies against predetermined inclusion/exclusion criteria. Two investigators independently extracted data on study populations, interventions, and outcomes and assessed study quality. RESULTS: Two randomized controlled trials, 2 cohort studies, and 11 case series assessed the effects of frenotomy on feeding, speech, and social outcomes. Bottle feeding and social concerns, such as ability to use the tongue to eat ice cream and clean the mouth, improved more in treatment groups in comparative studies. Supplementary bottle feedings decreased over time in case series. Two cohort studies reported improvement in articulation and intelligibility with treatment. Other benefits were unclear. One randomized controlled trial reported improved articulation after Z-frenuloplasty compared with horizontal-to-vertical frenuloplasty. Numerous noncomparative studies reported speech benefits posttreatment; however, studies primarily discussed modalities, with outcomes including safety or feasibility, rather than speech. We included English-language studies, and few studies addressed longer-term speech, social, or feeding outcomes; nonsurgical approaches, such as complementary and alternative medicine; and outcomes beyond infancy, when speech or social concerns may arise. CONCLUSIONS: Data are currently insufficient for assessing the effects of frenotomy on nonbreastfeeding outcomes that may be associated with @entity2 .

title: Treatment of XXXX for Reasons Other Than Breastfeeding: A Systematic Review.

answer: @entity2


abstract: INTRODUCTION AND AIM: Low Level Laser Therapy (LLLT) can facilitate wound healing stimulating a more rapid resolution and an earlier start for the proliferation phase. The purpose of this study is to evaluate the effects of LLLT on postoperative @entity2 and @entity1 following the removal of impacted lower third molars. MATERIALS AND METHODS: Fifty-nine @entity0 , who were to undergo surgical removal of their lower third molars, were studied. @entity0 were randomly allocated to one of three groups: 17 @entity0 LLLT + traditional drug treatment17 @entity0 traditional drug treatment as control group25 @entity0 treated with LLLT only on one side+traditional drug treatment. The laser we have used for this study is a diode laser, @entity3 , which delivers both in the infrared band at the wavelength of 910 nanometers (pulsed and superpulsed source), and in the visible (continuous source) at the wavelength of 650 nanometers (red). LLLT was performed just after the intervention and approximately 12 hours after surgery delivering 240 J in 15 minutes with theoretical fluence values of 480 J/cm(2) and 31 J/cm(2) for every minute of irradiation. We considered and signed with a label constant landmarks on both sides of the face of each @entity0 ; measurements were taken: before the surgery, after the surgery right after the 1st laser treatment, after approximately 24 hours after the 2(nd) laser treatment. RESULTS: We collected all the values of the @entity1 measurements and the VAS reports and performed a statistical analysis by means One-way Analysis of Variance (ANOVA) test: for the evaluated values (X, Y, Z) an extremely significant difference was found with p values of 0.003 for Y at the first evaluation (pre-12 hours) and less than 0.001 for the other evaluations. A significant result was obtained for VAS recorded at hospital discharge (p<0.0001). CONCLUSIONS: This study demonstrates that LLLT is effective on postoperative @entity2 and @entity1 accelerating healing time and reducing @entity0 distress.

title: Efficacy of LLLT in swelling and XXXX control after the extraction of lower impacted third molars.

answer: @entity2


abstract: UNASSIGNED: @entity2 ( @entity2 ) is a potentially devastating @entity1 . The pathogenesis of this @entity1 remains poorly elucidated. Previous studies focused on analysis of expression and function of known oncogenes and @entity1 suppressor genes. However, emerging reports highlight that it is also important to analyze the expression of genes that are ectopically expressed in @entity2 (e.g., embryonic stem cell genes (ESC), @entity1 ( @entity1 ) genes, etc.). Currently, it is not known whether ESC genes are expressed in @entity2 . In the current work, we analyze by RT-PCR the expression of 26 ESC genes, many of which are known to regulate pluripotency and promote @entity1 stem cell-like phenotype, in a historic cohort of 60 @entity0 from Boston and in a panel of 11 @entity0 -derived @entity2 cell lines and compare such expression to benign inflammatory dermatoses that often clinically mimic @entity2 . Our findings document that many critical ESC genes including @entity4 , @entity6 , @entity5 ( @entity5 ) and their upstream and downstream signaling members are expressed in @entity2 . Similarly, polycomb repressive complex 2 (PRC2) genes (i.e., @entity10 , @entity9 , and @entity13 ) are also expressed in @entity2 lesional skin. Furthermore, select ESC genes ( @entity5 , @entity9 , @entity8 , @entity15 , @entity11 , @entity12 , @entity14 ) are preferentially expressed in @entity2 samples when compared to benign skin biopsies. Our work suggests that ESC genes are ectopically expressed together with @entity1 genes, thymocyte development genes and B cell-specific genes and may be working in concert to promote tumorigenesis. Specifically, while ESC genes may be promoting @entity1 stem cell-like phenotype, @entity1 genes may be contributing to @entity3 and @entity7 by producing aberrant chromosomal translocations. Further analysis of ESC expression and function in this @entity1 will greatly enhance our fundamental understanding of @entity2 and will help us identify novel therapeutic targets.

title: Ectopic expression of embryonic stem cell and other developmental genes in XXXX .

answer: @entity2


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Pereskia aculeata Miller (Cactaceae), known as Barbados gooseberry, are used in Brazilian traditional medicine as emollients and to treat @entity6 and @entity2 . This study investigated the topical anti-inflammatory activity of the @entity16 fraction (HF) obtained from the @entity10 extract of the leaves of this species in models of @entity12 in @entity1 . MATERIAL AND METHODS: @entity1 ear @entity0 was induced by topical application of croton oil, @entity11 , @entity13 , @entity18 and @entity15 ; and by subcutaneous injection of @entity4 . Ear biopsies were obtained to determine the levels of @entity7 , @entity9 and @entity8 cytokines by ELISA assay. Histopathological analysis was also performed to evaluate the HF activity in croton oil multiple application test. In addition, acute dermal irritation/corrosion test in @entity3 was accomplished. HF chemical characterization was performed by GC-MS analysis. RESULTS: HF intensively reduced the inflammatory process induced by all irritant agents used, except for @entity11 . This activity is related, at least in part, to the reduction of @entity9 and @entity8 cytokines levels. Moreover, when the glucocorticoid receptor antagonist @entity14 was used, HF failed to respond to the croton oil application.The results strongly suggested a glucocorticoid-like effect, which was reinforced by the presence of considerable amounts of @entity17 compounds identified in HF. The acute dermal irritaton/corrosion test showed no signs of @entity5 . CONCLUSIONS: This study showed that the acute and chronic anti-inflammatory activity of P. aculeata leaves is very promising, and corroborates to better understand their ethnopharmacological applications.

title: Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of XXXX .

answer: @entity12