abstract: The acquisition of FSH receptor during preantral folliculogenesis is believed to be a key step in the subsequent development of follicles. We examined the interaction between activin and @entity1 in FSH receptor induction in @entity0 granulosa cells by measuring 125I-FSH binding and FSH receptor mRNA. In the 125I-FSH binding study, 0.2 mM @entity3 and 1 microM @entity2 were maximally effective in FSH receptor induction (169 and 220% respectively of control), while higher concentrations gave attenuated responses. It appears that @entity1 has ambivalent effects on FSH receptor induction depending on the concentration and length of exposure. Activin alone dramatically increased the number of FSH receptors (314% of control). Moreover, synergistic effects of activin and @entity3 or @entity2 were observed on FSH receptor induction: a combination of activin (80 ng/ml) and low doses of @entity3 (0.2 mM) or @entity2 (1 microM) was most effective (160 or 140% of that induced by activin alone) and receptor levels reached a maximum at 24 h. These levels than markedly decreased after 72 h of incubation. Northern blot analysis revealed that the combination of activin (80 ng/ml) and @entity3 (0.2 mM) or @entity2 (1 microM) increased FSH receptor mRNA to about 140% of that induced by activin alone. These results indicate that activin and @entity1 induced FSH receptor synergistically. However, activin did not enhance the production of @entity1 induced by @entity2 . In addition, a protein kinase A inhibitor (H89) (2 microM), which inhibited the effects of @entity2 , had no effect on the action of activin.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Interaction between activin A and XXXX in the induction of FSH receptor in cultured @entity0 granulosa cells.

answer: @entity1


abstract: The acquisition of FSH receptor during preantral folliculogenesis is believed to be a key step in the subsequent development of follicles. We examined the interaction between activin and @entity1 in FSH receptor induction in @entity0 granulosa cells by measuring 125I-FSH binding and FSH receptor mRNA. In the 125I-FSH binding study, 0.2 mM @entity3 and 1 microM @entity2 were maximally effective in FSH receptor induction (169 and 220% respectively of control), while higher concentrations gave attenuated responses. It appears that @entity1 has ambivalent effects on FSH receptor induction depending on the concentration and length of exposure. Activin alone dramatically increased the number of FSH receptors (314% of control). Moreover, synergistic effects of activin and @entity3 or @entity2 were observed on FSH receptor induction: a combination of activin (80 ng/ml) and low doses of @entity3 (0.2 mM) or @entity2 (1 microM) was most effective (160 or 140% of that induced by activin alone) and receptor levels reached a maximum at 24 h. These levels than markedly decreased after 72 h of incubation. Northern blot analysis revealed that the combination of activin (80 ng/ml) and @entity3 (0.2 mM) or @entity2 (1 microM) increased FSH receptor mRNA to about 140% of that induced by activin alone. These results indicate that activin and @entity1 induced FSH receptor synergistically. However, activin did not enhance the production of @entity1 induced by @entity2 . In addition, a protein kinase A inhibitor (H89) (2 microM), which inhibited the effects of @entity2 , had no effect on the action of activin.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Interaction between activin A and @entity1 in the induction of FSH receptor in cultured XXXX granulosa cells.

answer: @entity0


abstract: A number of operative techniques have been described for the treatment of herniated @entity6 . The transfacet pedicle-sparing approach allows for @entity7 limited spinal column disruption and soft-tissue dissection. Fifteen cadaveric spinal columns were used for evaluation of exposure, development of thoracic microdiscectomy instrumentation, and establishment of morphometric measurements. This approach was used to remove eight @entity6 in six @entity0 . Levels of herniation ranged from T-7 through @entity8 . Preoperatively, all @entity0 had moderate to severe @entity1 , and three (50%) of the six had @entity1 . @entity3 was present in four (67%) of the six @entity0 . Through a 4-cm opening, the ipsilateral paraspinal muscles were reflected, and a partial facetectomy was performed. The disc was then removed using specially designed microscopic instrumentation. Postoperatively, the @entity4 resolved in all @entity0 . @entity1 and @entity3 were completely resolved or significantly improved in all @entity0 . The minimal amount of bone resection and muscle dissection involved in the operation allows for: 1) decreased operative time and @entity2 ; 2) diminished perioperative @entity1 ; 3) shorter hospitalization time and faster return to premorbid activity; 4) avoidance of closed chest tube drainage; and 5) preservation of the integrity of the facet-pedicle complex, with potential for improvement in outcome related to @entity1 . This technique appears best suited for the removal of all centrolateral discs, although it has been used successfully for treating a disc occupying nearly the entire ventral canal. The initial experience suggests that this approach may be used to safely remove appropriately selected @entity5 with good results.

title: The transfacet pedicle-sparing approach for XXXX : cadaveric morphometric analysis and preliminary clinical experience.

answer: @entity6


abstract: BACKGROUND: Gastrointestinal bypass changes the gut microbiota and decreases systemic @entity5 in @entity1 subjects. Epithelial barrier integrity is crucial for confining enteric bacteria in the lumen and preventing gut-derived @entity5 . The effect of bypass surgery on intestinal barrier functions remains poorly understood. This study aimed to evaluate the changes in intestinal permeability and gut barrier between @entity2 receiving Roux-en-Y duodenojejunal bypass (DJB) or sham operation (SO). METHODS: Eighteen @entity2 were assigned to DJB or SO groups. Tissues of the alimentary, biliopancreatic, and common limbs in the small intestine, and the colon, were collected 2  weeks after operation. Mucosa-associated bacteria were quantified by colony forming units. Intestinal permeability was determined by mucosal-to-serosal dextran flux measured in Ussing chambers. Expression of @entity3 and @entity4 ( @entity4 ) in the intestinal mucosa was examined by western blots. RESULTS: Enteric bacterial numbers were increased in the alimentary and common limbs after DJB. Reduced dextran permeability was found in the alimentary limb, common limb, and colon after DJB. Moreover, increased villus height and crypt depth were found to be associated with higher mucosal levels of @entity3 and @entity4 levels in the alimentary and common limbs after DJB. CONCLUSIONS: DJB in @entity2 altered gut microbiota and reduced intestinal permeability due to increased epithelial proliferation and tight junctional protein expression. Our results show that bypass surgery led to fortification of the intestinal barrier functions, which may provide an explanation for the decreased risk of systemic @entity5 in postoperative @entity0 .

title: Duodenojejunal Bypass Leads to Altered Gut Microbiota and Strengthened Epithelial Barriers in XXXX .

answer: @entity2


abstract: PURPOSE: The aim of this study is to systematically evaluate the efficacy of commonly used non-surgical treatments in acute care of adults with @entity4 ( @entity4 ). METHODS: A systematic approach was used to search eight electronic databases for randomized controlled trials (RCTs) examining analgesic medications, passive physical therapies, bed rest or orthoses. Data on @entity0 , activity/participation and adverse events were extracted. Methodological quality and quality of evidence were assessed with the Physiotherapy Evidence Database (PEDro) scale (score range 0-10) and the GRADE criteria, respectively. RESULTS: Five RCTs (total n  =  350) were identified including one placebo-controlled and four controlled trials examining analgesics (2 studies) and orthoses (3). PEDro scores ranged from 4 to 7. The overall quality of evidence ranged from very low to low. In two trials, spinal orthoses provided significantly higher medium-term @entity0 relief [pooled standardized mean differences (SMD): -1.47, 95  % confidence interval (CI) -1.82, -1.13; I (2)  =  0  %] and disability reduction (pooled SMD: -1.73, 95  % CI -2.09, -1.37; I (2)  =  0  %) than no intervention. Immediate- and short-term @entity0 effects of @entity3 (a non-steroidal anti-inflammatory drug) and @entity2 (a strong opioid) were demonstrated when compared to a Chinese medicine, whereas non-significant effects were found for @entity1 and @entity6 (strong opioids) in a placebo-controlled trial. Low/insufficient statistical power, co-interventions and potential conflict of interest might have influenced the results. CONCLUSIONS: At present, there is insufficient evidence to inform conservative care for @entity5 related to VCF. Large, multinational, placebo/sham-controlled trials to address this gap in evidence are needed.

title: The efficacy of conservative treatment of @entity4 on XXXX relief: a systematic review with meta-analysis.

answer: @entity5


abstract: PURPOSE: The aim of this study is to systematically evaluate the efficacy of commonly used non-surgical treatments in acute care of adults with @entity4 ( @entity4 ). METHODS: A systematic approach was used to search eight electronic databases for randomized controlled trials (RCTs) examining analgesic medications, passive physical therapies, bed rest or orthoses. Data on @entity0 , activity/participation and adverse events were extracted. Methodological quality and quality of evidence were assessed with the Physiotherapy Evidence Database (PEDro) scale (score range 0-10) and the GRADE criteria, respectively. RESULTS: Five RCTs (total n  =  350) were identified including one placebo-controlled and four controlled trials examining analgesics (2 studies) and orthoses (3). PEDro scores ranged from 4 to 7. The overall quality of evidence ranged from very low to low. In two trials, spinal orthoses provided significantly higher medium-term @entity0 relief [pooled standardized mean differences (SMD): -1.47, 95  % confidence interval (CI) -1.82, -1.13; I (2)  =  0  %] and disability reduction (pooled SMD: -1.73, 95  % CI -2.09, -1.37; I (2)  =  0  %) than no intervention. Immediate- and short-term @entity0 effects of @entity3 (a non-steroidal anti-inflammatory drug) and @entity2 (a strong opioid) were demonstrated when compared to a Chinese medicine, whereas non-significant effects were found for @entity1 and @entity6 (strong opioids) in a placebo-controlled trial. Low/insufficient statistical power, co-interventions and potential conflict of interest might have influenced the results. CONCLUSIONS: At present, there is insufficient evidence to inform conservative care for @entity5 related to VCF. Large, multinational, placebo/sham-controlled trials to address this gap in evidence are needed.

title: The efficacy of conservative treatment of XXXX on @entity5 relief: a systematic review with meta-analysis.

answer: @entity4


abstract: BACKGROUND: @entity4 is a major barrier to achieving optimal glycemic control and managing @entity1 successfully in @entity0 with @entity1 . Falls are the most significant consequences caused by @entity4 episodes. Both @entity4 and falls lead to substantial economic burden on the health care system in the United States. OBJECTIVE: To examine the association of @entity4 with fall-related outcomes in elderly @entity0 with @entity1 ( @entity1 ).   METHODS: Records were obtained for @entity1 @entity0 (N   =   1,147,937) from January 1, 2008, to December 31, 2011. The nonhypoglycemia @entity0 were randomly matched 1:1 by age and gender to the @entity4 @entity0 . Fall-related events (composite of fall-related outcomes) were defined using ICD-9-CM codes. Conditional logistic regression models were used to compare the fall-related events within 30 days, 90 days, 180 days, and 365 days between the 2 cohorts.   RESULTS: A total of 21,613 @entity4 @entity0 were matched with 21,613 nonhypoglycemic @entity0 . @entity0 with @entity4 had higher fall-related events within 30 days, 90 days, 180 days, and 365 days (P    less than    0.001 for all frequency differences). Conditional logistic regression analyses showed an elevated risk for fall-related events over 365 days (aOR   =   1.95, 95% CI   =   1.70-2.24). Subgroup analysis showed elevated risk for @entity0 aged less than    75 years and >=    75 years. Elevated risks were also seen for individual fall-related outcomes of @entity2 , @entity3 , long-term care placement, and hospital admissions. CONCLUSIONS: The risk of fall-related events over 365 days increased 2-fold among elderly @entity0 with @entity1 who experienced @entity4 .

title: Association between @entity4 and fall-related events in XXXX : analysis of a u.s. Commercial database.

answer: @entity1


abstract: BACKGROUND: @entity4 is a major barrier to achieving optimal glycemic control and managing @entity1 successfully in @entity0 with @entity1 . Falls are the most significant consequences caused by @entity4 episodes. Both @entity4 and falls lead to substantial economic burden on the health care system in the United States. OBJECTIVE: To examine the association of @entity4 with fall-related outcomes in elderly @entity0 with @entity1 ( @entity1 ).   METHODS: Records were obtained for @entity1 @entity0 (N   =   1,147,937) from January 1, 2008, to December 31, 2011. The nonhypoglycemia @entity0 were randomly matched 1:1 by age and gender to the @entity4 @entity0 . Fall-related events (composite of fall-related outcomes) were defined using ICD-9-CM codes. Conditional logistic regression models were used to compare the fall-related events within 30 days, 90 days, 180 days, and 365 days between the 2 cohorts.   RESULTS: A total of 21,613 @entity4 @entity0 were matched with 21,613 nonhypoglycemic @entity0 . @entity0 with @entity4 had higher fall-related events within 30 days, 90 days, 180 days, and 365 days (P    less than    0.001 for all frequency differences). Conditional logistic regression analyses showed an elevated risk for fall-related events over 365 days (aOR   =   1.95, 95% CI   =   1.70-2.24). Subgroup analysis showed elevated risk for @entity0 aged less than    75 years and >=    75 years. Elevated risks were also seen for individual fall-related outcomes of @entity2 , @entity3 , long-term care placement, and hospital admissions. CONCLUSIONS: The risk of fall-related events over 365 days increased 2-fold among elderly @entity0 with @entity1 who experienced @entity4 .

title: Association between XXXX and fall-related events in @entity1 : analysis of a u.s. Commercial database.

answer: @entity4


abstract: BACKGROUND: @entity5 ( @entity5 ) are the most common @entity6 of the brain. They are most commonly asymptomatic and often diagnosed incidentally. ILLUSTRATIVE CASE: We present a rare case of a 9-year-old @entity0 with @entity3 caused by a subcortically located @entity8 posterior to the postcentral gyrus of the left brain hemisphere. MRI also showed an enlarged, microcystically altered pineal gland and an extracranial @entity7 . EEG showed left fronto-centro-parietal spikes that corresponded with the location of the @entity8 . The spikes were occasionally secondary generalized. The @entity0 responded well to oxcarbazepine treatment, and no surgical intervention was required. Control MRI scans showed no progression of the @entity8 . CONCLUSION: @entity2 may be caused by @entity8 . The treatment starts with anticonvulsants. The surgical treatment is the therapeutic choice only if @entity3 are resistant to conservative therapy because surgery might result in serious @entity1 or @entity4 complications because @entity5 are considered to be variations of normal transmedullary veins that are necessary for the drainage of white and gray matter.

title: XXXX in a @entity0 with a @entity5 -case-based update.

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ) are the most common @entity6 of the brain. They are most commonly asymptomatic and often diagnosed incidentally. ILLUSTRATIVE CASE: We present a rare case of a 9-year-old @entity0 with @entity3 caused by a subcortically located @entity8 posterior to the postcentral gyrus of the left brain hemisphere. MRI also showed an enlarged, microcystically altered pineal gland and an extracranial @entity7 . EEG showed left fronto-centro-parietal spikes that corresponded with the location of the @entity8 . The spikes were occasionally secondary generalized. The @entity0 responded well to oxcarbazepine treatment, and no surgical intervention was required. Control MRI scans showed no progression of the @entity8 . CONCLUSION: @entity2 may be caused by @entity8 . The treatment starts with anticonvulsants. The surgical treatment is the therapeutic choice only if @entity3 are resistant to conservative therapy because surgery might result in serious @entity1 or @entity4 complications because @entity5 are considered to be variations of normal transmedullary veins that are necessary for the drainage of white and gray matter.

title: @entity2 in a @entity0 with a XXXX -case-based update.

answer: @entity5


abstract: BACKGROUND: @entity5 ( @entity5 ) are the most common @entity6 of the brain. They are most commonly asymptomatic and often diagnosed incidentally. ILLUSTRATIVE CASE: We present a rare case of a 9-year-old @entity0 with @entity3 caused by a subcortically located @entity8 posterior to the postcentral gyrus of the left brain hemisphere. MRI also showed an enlarged, microcystically altered pineal gland and an extracranial @entity7 . EEG showed left fronto-centro-parietal spikes that corresponded with the location of the @entity8 . The spikes were occasionally secondary generalized. The @entity0 responded well to oxcarbazepine treatment, and no surgical intervention was required. Control MRI scans showed no progression of the @entity8 . CONCLUSION: @entity2 may be caused by @entity8 . The treatment starts with anticonvulsants. The surgical treatment is the therapeutic choice only if @entity3 are resistant to conservative therapy because surgery might result in serious @entity1 or @entity4 complications because @entity5 are considered to be variations of normal transmedullary veins that are necessary for the drainage of white and gray matter.

title: @entity2 in a XXXX with a @entity5 -case-based update.

answer: @entity0


abstract: @entity8 after cardiac valve replacement is a dreaded complication with consequent mortality estimated as high as 70%. We have reviewed 2,491 @entity0 with @entity4 to assess the impact of @entity8 upon mortality in our institution in the past 10 years. @entity8 developed after valve replacement in 36 @entity0 (1.4%). All @entity0 required operative intervention for @entity3 with positive bacterial cultures. Twelve of these @entity0 had other perioperative problems associated with a high mortality independent of @entity8 : @entity9 not cured by valve replacement (three), recent preoperative @entity6 (four), @entity5 with @entity2 (one), and severe perioperative @entity1 (four). Ten of these high-risk @entity0 died (83.3%). The impact of @entity8 upon survival is best evaluated in the remaining 24 @entity0 without high-risk perioperative problems. Eight of these @entity0 were managed before 1980 with d  bridement and irrigation as the primary treatment, with two hospital deaths (25%). Pectoral or rectus muscle flaps were frequently used after 1980 (flaps in 11 of 16 @entity0 ), leading to a significantly shorter time between diagnosis of @entity3 (62 versus 385 days, p less than 0.05). Only one of these 16 @entity0 died. Valve re-replacement for @entity7 was performed in three of these 24 @entity0 although 13 of 24 had positive blood cultures. @entity8 after valve operations in the absence of other high-risk perioperative problems can be successfully managed. Early d  bridement and muscle flap closure has led to a 94% survival rate in 16 @entity0 during the past 4 years.

title: XXXX after @entity4 . Impact upon survival.

answer: @entity8


abstract: @entity8 after cardiac valve replacement is a dreaded complication with consequent mortality estimated as high as 70%. We have reviewed 2,491 @entity0 with @entity4 to assess the impact of @entity8 upon mortality in our institution in the past 10 years. @entity8 developed after valve replacement in 36 @entity0 (1.4%). All @entity0 required operative intervention for @entity3 with positive bacterial cultures. Twelve of these @entity0 had other perioperative problems associated with a high mortality independent of @entity8 : @entity9 not cured by valve replacement (three), recent preoperative @entity6 (four), @entity5 with @entity2 (one), and severe perioperative @entity1 (four). Ten of these high-risk @entity0 died (83.3%). The impact of @entity8 upon survival is best evaluated in the remaining 24 @entity0 without high-risk perioperative problems. Eight of these @entity0 were managed before 1980 with d  bridement and irrigation as the primary treatment, with two hospital deaths (25%). Pectoral or rectus muscle flaps were frequently used after 1980 (flaps in 11 of 16 @entity0 ), leading to a significantly shorter time between diagnosis of @entity3 (62 versus 385 days, p less than 0.05). Only one of these 16 @entity0 died. Valve re-replacement for @entity7 was performed in three of these 24 @entity0 although 13 of 24 had positive blood cultures. @entity8 after valve operations in the absence of other high-risk perioperative problems can be successfully managed. Early d  bridement and muscle flap closure has led to a 94% survival rate in 16 @entity0 during the past 4 years.

title: @entity8 after XXXX . Impact upon survival.

answer: @entity4


abstract: Although @entity3 is a choice made by the @entity0 , there are many psychological factors involved and often after the abortion many @entity0 have lasting psychological reactions which may go on for many months or years. Looking back upon a study conducted on 1000 @entity0 in Geneva in 1971, abortion was not always found to be a true choice, but rather the last remedy for reestablishing a balance that an unwanted @entity0 disturbs. Research conducted in Geneva, London, and New York showed that the case histories of @entity0 who had resorted to abortion revealed @entity2 and @entity1 of a conflicting nature toward their mothers going back to their childhood. These @entity0 displayed a distorted affectivity, both on the sexual plane and also in couple relationships. The desire for pregnancy seems to persist even after the abortion, but there is a contradictory affection because the @entity0 on the 1 hand is loved, but on the other is looked upon as a rival destined to do away with his parents. In 1973 WHO reported that many @entity0 who had resorted to abortion frequently suffered remorse and regret later followed by a sense of relief. However, 3-6 months after the abortion the event continued as an agonizing memory. Recent surveys taken in Switzerland proved that often the choice of an abortion made on a rational basis could clash with an unconscious but intense desire for pregnancy, and the sense of guilt which remained at a latent level was often responsible for the difficulty in getting through the @entity1 . The @entity1 that accompanies abortion is 1st somatic and then psychic. The somatic part can be partially avoided by refining the intervention techniques, but the psychic part can be dealt with only by psychological intervention and, unlike the somatic @entity1 , its effects last much longer. While the @entity0 is making the decision to have the abortion, she is in balance; when the abortion is actually performed, however, the choice no longer exists because the ultimate goal has been achieved and she falls out of balance due to her conflicting feelings. It is best that decisions of this nature be made slowly because the psychological effects of a hasty decision can go on long after abortion.

title: [Psychoreactivity in XXXX ].

answer: @entity3


abstract: PURPOSE: To describe the changes in the characteristics of @entity0 treated for severe @entity1 ( @entity1 ) in a tertiary referral unit in China after screening guidelines were issued in 2004 and to evaluate the effectiveness of the current criteria. METHODS: Information on consecutive @entity0 referred to a single eye department for treatment of Stage 3 (Type 1 pretheshold and threshold disease), Stage 4, and Stage 5 @entity1 between January 2001 and May 2012 was retrieved from medical records. RESULTS: The mean gestational age was 29.98    2.13 weeks (range 26-34 weeks), and the mean birth weight was 1,414.32    343.18 g (range 742-2,087 g). The proportion of @entity0 with Stage 4 and Stage 5 @entity1 decreased statistically significantly over time (P = 0.026 and P < 0.001, respectively) after screening guidelines for @entity1 were issued in 2004. The median postmenstrual age when @entity0 first visited the study hospital was 48.32 weeks (range 30-602 weeks); later presentation was significantly associated with more advanced @entity1 (P < 0.001). In addition, the postmenstrual age of first presentation showed a significant decrease over time (P < 0.001) after the screening guidelines were issued. The current Chinese screening guidelines cover 99.63% of @entity0 while 9.07% of @entity0 exceeded the U.K. screening criteria and 35.77% of @entity0 exceeded the U.S. criteria. CONCLUSION: After the government issued guidelines on @entity1 screening, the birth weight and gestational age of severe @entity1 @entity0 remain similar. Big @entity0 got severe @entity1 as before. But the awareness of @entity1 increased, the proportion of @entity0 with @entity2 caused by @entity1 decreased, and the @entity0 received more timely treatment. The current @entity1 screening criteria are very effective.

title: ANALYSIS OF CHANGES IN CHARACTERISTICS OF SEVERE RETINOPATHY OF PREMATURITY XXXX AFTER SCREENING GUIDELINES WERE ISSUED IN CHINA.

answer: @entity0


abstract: BACKGROUND: Altered flow in ductus venosus (DV) may be caused by the changes in preload or afterload. Its association with @entity1 and @entity4 ( @entity4 ) was widely described. OBJECTIVES: The aim of this study was to examine the incidence of a reversed a-wave in DV flow (revDV) and the absence of DV (noDV), their coincidences with other markers of @entity2 in a mixed-risk population. METHODS: The study group covered @entity0 who underwent an ultrasound scan between 11+0 and 13+6 weeks' gestation. Applied inclusion criteria: Singleton pregnancies with known pregnancy outcome and a crown-rump length of 45-84 mm. RESULTS: A total of 5811 cases, including 137 @entity1 , met the inclusion criteria: 35 subjects of noDV, 189 of revDV and 5587 of normal DV flow. The incidence of noDV in euploidy was 0.47%, and in @entity1 5.8%. The incidence of revDV in euploidy was 2.46%, and in @entity1 35.7%. Among @entity1 , the highest prevalence of noDV was found in monosomy 45X. revDV showed the highest prevalence in trisomy 18. Isolated noDV was only found in euploidy. Isolated revDV subjects were only observed in euploidy and trisomy 21. Any combination of revDV with additional markers showed high incidence in major trisomies. Extracardiac anatomy and abnormal cardiac findings showed a higher prevalence in noDV and revDV cases. CONCLUSIONS: The presence of noDV might be useful in suspicion of @entity3 among cases with increased nuchal translucency, as well as in differentiating them from other @entity1 . The combinations of @entity1 markers with revDV are strong indicators of @entity1 . revDV alone is a poor screening tool for @entity1 and euploidy with CHD.

title: First trimester severe ductus venosus flow abnormalities in isolation or combination with other markers of XXXX .

answer: @entity2


abstract: BACKGROUND: Many @entity0 with @entity2 ( @entity2 ) have insufficient knowledge about @entity2 , which is associated with poorer health outcomes. Effective @entity0 -provider communication can improve @entity2 @entity0 ' knowledge, thereby augmenting their participation in self-care practices. However, barriers to addressing @entity2 @entity0 ' information needs have not been previously characterized. METHODS: Adults with an estimated glomerular filtration rate (eGFR) of <60 mL/ @entity3 .73 m(2) or on chronic dialysis or with a kidney transplant were recruited from a Department of Veterans Affairs (VA) nephrology clinic. Semi-structured telephone interviews were conducted to assess @entity0 ' @entity2 information needs and demographic characteristics. A qualitative approach was used to analyze interview transcripts and identify themes pertaining to communication dynamics. RESULTS: Thirty-two @entity0 participated. The mean age of @entity0 was 63 years; most were male (94%) and non-Hispanic white (53%). @entity2 severity groups represented included @entity2 -3 (eGFR 30-59 mL/ @entity3 .73 m(2); 34%), @entity2 -4 (eGFR 15-29 mL/ @entity3 .73 m(2); 25%), @entity2 -5 (eGFR <15 mL/ @entity3 .73 m(2); 16%), @entity1 on dialysis (13%) and kidney transplant recipients (12%). Several key themes emerged about barriers to @entity0 -provider communication based on @entity0 ' reported care at both VA and non-VA facilities, including @entity0 perceived their role as a 'listener', reported limited @entity2 knowledge, did not understand physicians' explanations and were dissatisfied with the @entity0 -provider relationship. CONCLUSIONS: Several barriers to @entity0 -provider communication prevent @entity0 from meeting their information needs and perpetuate @entity0 passivity. Future research should evaluate whether interventions that empower @entity2 @entity0 to actively participate in their care increase knowledge and improve health outcomes.

title: Barriers to effective communication between veterans with XXXX and their healthcare providers.

answer: @entity2


abstract: UNASSIGNED: Background.    @entity3 is a leading cause of @entity2 , and there are limited data on prognosis markers in disease development. We aimed to study 3 virology targets (glycoprotein [g]B, gN, and UL144) to assess their correlation with @entity2 and various organ system involvement. Methods.    Forty-eight congenital cases and 58 postnatally infected @entity0 were included (2003-2014). Genotyping for the 3 targets and distribution among the cohorts were investigated, and the relationship between the gB, gN, and UL144 types with clinical manifestations in @entity2 was also studied. Results.    All of the genotypes were similarly represented among cohorts, and the most prevalent were the UL144B, @entity5 , and @entity6 genotypes. The @entity4 genotype was associated with abnormal image findings by ultrasound and/or magnetic resonance in @entity2 (odds ratio [OR], 6.2; 95% confidence interval [CI], 1.1-34.3; P = .036); the @entity6 genotype was associated with an elevated risk of developing @entity1 (OR, 7.0; 95% CI, 1.1-45.9; P = .043). Both @entity6 and @entity4 were independent factors for symptomatic @entity2 . Statistical analyses showed no association between any UL144 genotype and disease severity. Conclusions.    All of the genotypes can be involved in @entity2 , although the @entity4 and @entity6 genotypes might be associated with a more serious illness.

title: Cytomegalovirus Genotype Distribution Among Congenitally and Postnatally Infected XXXX : Association of Particular Glycoprotein (g)B and gN Types With Symptomatic Disease.

answer: @entity0


abstract: BACKGROUND: Odontogenic infections may result in local, systemic, and even potentially life-threatening complications. The authors investigated whether water fluoridation was associated with reduction in rates of hospitalizations due to odontogenic infections. METHODS: The authors included cities in Israel that had @entity2 concentrations of either 0.7 milligrams per liter or more (optimally fluoridated) or 0.5  mg/L or less (nonoptimally fluoridated) and that had a public water @entity2 concentration consistent for the last decade. The authors compared hospitalization rates (per 10,000 @entity0 ) for odontogenic infections in @entity0 younger than 18 years in each socioeconomic group between optimally and nonoptimally fluoridated cities. RESULTS: The authors included 1,413 hospitalizations between January 2005 and December 2011 of @entity0 residing in the 38 studied municipalities. The cities with the higher @entity2 concentration reported a lower hospitalization rate (2.0 versus 4.3 for cities with a lower @entity2 concentration; relative risk [RR]: 2.16; P  < .001). When the authors divided cities into 3 socioeconomic groups, a large difference in hospitalization rates was seen in the lowest socioeconomic group (10.1 versus 2.6; RR: 3.79; P  < .001) and the middle socioeconomic group (3.6 versus 1.9; RR: 2.35; P  < .001) in optimally and nonoptimally fluoridated cities, respectively. No significant difference in hospitalization rates was apparent between the 2 fluoridation groups in the higher socioeconomic level. CONCLUSIONS: These results clearly indicate that there is an association between adequacy of water fluoridation and hospitalization due to @entity1 among @entity0 and adolescents. This effect is more prominent in populations of lower socioeconomic status. PRACTICAL IMPLICATIONS: Water fluoridation is associated with reduction in dental health disparity.

title: Hospitalizations for XXXX : Optimally versus nonoptimally fluoridated areas in Israel.

answer: @entity1


abstract: UNASSIGNED: Significant progress has been made in the treatment of @entity2 ( @entity2 ) @entity0 during the last two decades. In this review we present a personal case study for discussion on contemporary management in @entity2 . Presently immunochemotherapy using @entity4 , @entity1 , and rituximab (FCR) is the standard upfront regimen for physically fit @entity0 requiring treatment. @entity0 older than 65  years can be treated with modified doses of FCR, @entity7 , or @entity5 combined with anti- @entity3 antibody. This treatment can be repeated at relapse when the duration of response is over 2  years. @entity0 at high risk (with 17p deletion or early relapse) need alternative treatment with novel agents, e.g. @entity6 or @entity8 . However, the optimal use of the novel agents in terms of duration, combinations, and long-term adverse effects is unknown. In selected eligible @entity0 at high risk, allogeneic transplantation should be considered. Clinical trials in all stages of treatment are encouraged.

title: Pitting new treatments for XXXX against old ones: how do they fare?

answer: @entity2


abstract: OBJECTIVE: Until now the problem of the typical age of @entity2 onset has been actively discussing in the world literature. Though there are more and more publications, which mention the growth in the number of cases with late-onset and @entity1 , a conviction that @entity2 is the illness of teenagers or young @entity0 is still exists. Author aimed to determine a preferable age of the onset of @entity2 . MATERIAL AND METHODS: Data obtained in multi-year epidemiological research in Mental Health Research Center (Moscow) were analized. The total number of @entity0 with @entity2 and spectrum disorders was 5486. A subgroup of the @entity0 with the diagnosis that met the current diagnostic criteria of @entity2 included 1108 @entity0 . The study was based on clinical-epidemiological and statistical methods. RESULTS: Most of @entity0 had early onset @entity2 (16-20 years old maximum). However, it mostly depended on demographic factors, because more than half of @entity0 were young or middle aged at the moment of the examination. The examination of the group aged over 60 years and those who conditionally belonged to this generation (if 100% would have lived to that age) showed that the maximum number of @entity0 had onset between 30-40 years old. CONCLUSION: This research demonstrates the essential predominance of cases with onset of the disease in adolescent and young age that may be rather related with demographic characteristics than pathogenetic mechanisms of @entity2 . The latter determine predominantly middle age of disease onset (30-40 years). Cases both with early and late onset of the disease are not rare and are random deviations from the mean valuation.

title: [ XXXX : age at disease onset].

answer: @entity2


abstract: UNASSIGNED: The type-h thioredoxins (TRXs) play a fundamental role in oxidative stress tolerance and defense responses against pathogens. In pepper plants, type-h TRXs participate in the defense mechanism against @entity0 . The goal of this study was to analyze the role of the CaTRXh1-cicy gene in pepper plants during compatible interaction with a DNA virus, the @entity3 -Yucatan Peninsula (EuMV-YP). The effects of a transient silencing of the CaTRXh1-cicy gene in pepper plants w  re evaluated by observing the accumulation of viral DNA and the visible symptoms of pepper plants under different treatments. The accumulation of @entity1 (SA) and the relative expression of the defense genes @entity2 and PR10 were also evaluated. Results showed that viral DNA accumulation was higher in transiently CaTRXh1-cicy silenced plants that were also infected with EuMV-YP. Symptoms in these plants were more severe compared to the non-silenced plants infected with EuMV-YP. The SA levels in the EuMV-YP-infected plants were rapidly induced at 1  h post infection (hpi) in comparison to the non-silenced plants inoculated with EuMV-YP. Additionally, in pepper plants infected with EuMV-YP, the expression of @entity2 decreased by up to 41 and 58  % at 28  days post infection (dpi) compared to the non-silenced pepper plants infected with only EuMV-YP and healthy non-inoculated pepper plants, respectively. PR10 gene expression decreased by up to 70  % at 28 dpi. Overall, the results indicate that the CaTRXh1-cicy gene participates in defense mechanisms during the compatible interaction of pepper plants with the EuMV-YP DNA virus.

title: Expression of genes involved in the XXXX pathway in type h1 thioredoxin transiently silenced pepper plants during a begomovirus compatible interaction.

answer: @entity1


abstract: A procedure to enrich microbodies from @entity0 and a method to evaluate the purity and integrity of the microbodies are described. As a @entity0 microbody marker @entity2 ( @entity2 ) was used. The @entity0 hyphae were converted into protoplasts with Novozym 234. In Percoll-sucrose buffer the protoplasts were separated from @entity1 after 10,000 x g centrifugation. Purified protoplasts were lysed, and the cell homogenate was centrifuged to form a 14,000 x g pellet. After 2 h, 45,000 x g isopycnic centrifugation of the 14,000 x g pellet on a continuous 20-60% nycodenz gradient, ten fractions were collected. The fractions were analyzed for @entity2 containing microbodies by immuno-blotting and immuno-electron microscopy. The results showed that @entity2 -microbodies are enriched in the 38% nycodenz fraction. The microbodies had a diameter of 400 to 500 nm, revealed an intact single membrane and confined @entity2 . The estimated equilibrium density of the P. chyrsogenum microbodies was 1.20 g ml-1 as deduced from the 38% (w/v) nycodenz concentration.

title: Enrichment of XXXX microbodies by isopycnic centrifugation in nycodenz as visualized with immuno-electron microscopy.

answer: @entity0


abstract: Flies achieve supreme flight maneuverability through a small set of miniscule steering muscles attached to the wing base. The fast flight maneuvers arise from precisely timed activation of the steering muscles and the resulting subtle modulation of the wing @entity0 . In addition, slower modulation of wing kinematics arises from changes in the activity of indirect flight muscles in the thorax. We investigated if these modulations can be described as a superposition of a limited number of @entity0 that are under independent physiological control. Using a high-speed computer vision system, we recorded the wing motion of tethered flying @entity1 for up to 12 000 consecutive wing strokes at a sampling rate of 6250 Hz. We then decomposed the joint motion pattern of both wings into components that had the minimal mutual information (a measure of statistical dependence). In 100 flight segments measured from 10 individual flies, we identified 7 distinct types of frequently occurring least-dependent components, each defining a kinematic pattern (a specific deformation of the wing @entity0 and the sequence of its activation from cycle to cycle). Two of these @entity0 can be associated with the control of yaw torque and total flight force, respectively. A third deformation involves a change in the downstroke-to-upstroke duration ratio, which is expected to alter the pitch torque. A fourth kinematic pattern consists in the alteration of @entity0 amplitude with a period of 2 wingbeat cycles, extending for dozens of cycles. Our analysis indicates that these four elementary kinematic patterns can be activated mutually independently, and occur both in isolation and in linear superposition. The results strengthen the available evidence for independent control of yaw torque, pitch torque, and total flight force. Our computational method facilitates systematic identification of novel patterns in large kinematic datasets.

title: Independently Controlled Wing Stroke Patterns in the XXXX @entity1 .

answer: @entity1


abstract: Flies achieve supreme flight maneuverability through a small set of miniscule steering muscles attached to the wing base. The fast flight maneuvers arise from precisely timed activation of the steering muscles and the resulting subtle modulation of the wing @entity0 . In addition, slower modulation of wing kinematics arises from changes in the activity of indirect flight muscles in the thorax. We investigated if these modulations can be described as a superposition of a limited number of @entity0 that are under independent physiological control. Using a high-speed computer vision system, we recorded the wing motion of tethered flying @entity1 for up to 12 000 consecutive wing strokes at a sampling rate of 6250 Hz. We then decomposed the joint motion pattern of both wings into components that had the minimal mutual information (a measure of statistical dependence). In 100 flight segments measured from 10 individual flies, we identified 7 distinct types of frequently occurring least-dependent components, each defining a kinematic pattern (a specific deformation of the wing @entity0 and the sequence of its activation from cycle to cycle). Two of these @entity0 can be associated with the control of yaw torque and total flight force, respectively. A third deformation involves a change in the downstroke-to-upstroke duration ratio, which is expected to alter the pitch torque. A fourth kinematic pattern consists in the alteration of @entity0 amplitude with a period of 2 wingbeat cycles, extending for dozens of cycles. Our analysis indicates that these four elementary kinematic patterns can be activated mutually independently, and occur both in isolation and in linear superposition. The results strengthen the available evidence for independent control of yaw torque, pitch torque, and total flight force. Our computational method facilitates systematic identification of novel patterns in large kinematic datasets.

title: Independently Controlled Wing Stroke Patterns in the @entity1 XXXX .

answer: @entity1


abstract: In the absence of immunosuppressive treatment, suspensions of cells from the developing septal region of @entity0 embryos were transplanted successfully into the denervated hippocampal formations of adult @entity1 hosts. The longitudinal recovery of @entity2 ( @entity2 )-containing fibers in the host was the index of transplant success. In transplant recipients, the fornix-fimbrial interconnection between the septum and hippocampal formation was severed unilaterally, and two 5 microliter aliquots of cell suspension were injected into the hippocampal formations of host @entity1 . Five sets of controls included one in which animals received no surgical intervention (Normal Controls), and another which was subjected to a sham operation (Sham Controls). The fornix-fimbria pathway was transected unilaterally in Lesion Control animals, while Hippocampal Controls received the same lesion plus two injections of non-cholinergic cells from the hippocampal formations of @entity0 embryos. Injection Controls were subjected to a fornix-fimbria transection and given two injections of debris and dead cells in saline. The cross-species transplants induced the return of a normal @entity2 laminar pattern in the recipient @entity1 . The density of the laminar pattern, quantified with laser densitometry, was greatest in transplants that had survived for one week, but only in sections adjacent to the injection sites. Although the density decreased from the first through third weeks of survival, overall density of @entity2 staining stabilized from the fourth through 17th weeks of survival. Because the success rates of these cross-species transplants were similar to those reported for homogenic tissue, it was concluded that the @entity1 brain is a suitable host for xenogenic transplants of septal neurons from embryonic @entity0 .

title: Cross-species neural transplants of embryonic septal nuclei to the hippocampal formation of adult XXXX .

answer: @entity1


abstract: OBJECTIVE: to evaluate the efficacy of combination therapy with three antiglaucoma agents ( @entity4 + @entity5 / @entity3 ) for @entity2 . MATERIAL AND METHODS: The study enrolled 20 @entity0 with anterior @entity1 complicated by intraocular pressure (IOP) elevation. Besides standard anti-inflammatory agents, the treatment included IOP-lowering instillations, namely @entity4 2% 3 times daily and @entity3 0.5% 2 times daily. Those @entity0 whose IOP remained uncompensated were then switched to a three-drug regimen: @entity4 2% 3 times daily and a fixed combination of @entity5 0.2%, an aLPHA2-receptor agonist, and @entity3 0.5%, a 3-blocker, 2 times daily (Combigan, Allergan). IOP was measured with Maklakov tonometer three times during the day before the treatment and then three times daily while performing the two- or three-drug combination therapy. RESULTS: The mean initial IOP was 34.57 +/- 0.09 mmHg with daily fluctuations of 5.2 +/- 0.08 mmHg. After starting the unfixed combination therapy ( @entity4 + @entity3 ) the mean IOP decreased by 7.86 +/- 0.07 mmHg. Switching to the three-drug therapy ( @entity4 + @entity5 / @entity3 ) enabled an additional decrease in IOP by 5.43 +/- 0.06 mmHg. Thus, with the new regimen the total decrease in IOP averaged 13.29 +/- 0.09 mmHg with daily fluctuations of 2.5?0.06 mmHg, which ensured that the target IOP was achieved in all @entity0 . All the drugs were well-tolerated. CONCLUSION: Combination therapy with three antiglaucoma agents in the form of two medications-- @entity4 2% and @entity5 / @entity3 fixed combination (Combigan)--is shown to be effective in @entity2 @entity0 .

title: [Current therapeutic possibilities for XXXX ].

answer: @entity2


abstract: CLINICAL/METHODICAL ISSUE: Despite an increased cardiovascular risk in @entity0 with @entity1 they are a heterogeneous population with very different individual manifestation of diseases; therefore, a profound stratification is recommended. STANDARD METHODS: Clinical examinations and blood biomarkers are typically used in @entity1 @entity0 to determine the risk for developing cardio-cerebrovascular events. METHODICAL INNOVATIONS: Cardiac as well as whole-body magnetic resonance imaging (MRI) including cardiovascular sequences are established methods for clinical diagnostics. Their significance in predicting the outcome and the corresponding risk stratification for @entity0 with @entity1 is becoming increasingly more important based on recent study results. PERFORMANCE: Late @entity4 enhancement (LGE) in cardiac MRI detects silent @entity3 in up to 30   % of @entity1 @entity0 , which is associated with a hazard ratio of 3-6 for cardiovascular events. Regional left ventricular wall motion abnormalities and decreased ejection fraction also have a prognostic value in @entity1 . Based on whole-body MRI, the vessel score as well as @entity2 have been evaluated as additional predictors for cardio-cerebrovascular events. ACHIEVEMENTS: The MRI-based predictors have independent and incremental prognostic value beyond traditional risk stratification for cardio-cerebrovascular events; however, only the comprehensive assessment of whole-body MRI including angiography allows the identification of @entity0 who remain free of cardio-cerebrovascular events over a period of 6  years. PRACTICAL RECOMMENDATIONS: Cardiac MRI, particularly the detection of LGE, can be recommended for risk stratification of @entity0 with @entity1 . The clinical relevance of the added prognostic value of whole-body MRI needs to be clarified in further studies.

title: [Prognostic value of cardiovascular MRI in XXXX .]

answer: @entity1


abstract: UNASSIGNED: The cuticle of the @entity0 @entity0 is a specialized extracellular matrix whose major component is collagen. Cuticle collagens are encoded by a large multigene family consisting of more than 150 members. Cuticle collagen genes are expressed in epidermis (hypodermis) and may be stage-specific or cyclically expressed. We identified cuticle collagen genes as transcriptional targets of the @entity1 TGF-b-related signaling pathway. These studies prompted us to investigate the cis-regulatory sequences required for transcription of one of the target genes, @entity2 . We generated reporter constructs that reproduce stage- and tissue-specific expression of fluorescent markers. We identify four conserved sequence elements that are required for transcription of reporters. Finally, we provide evidence that @entity2 expression is controlled by a sequence element containing two GATA sites and by the epidermal GATA transcription factors @entity3 and @entity4 . genesis, 2015.    2015 Wiley Periodicals, Inc.

title: Multiple cis elements and GATA factors regulate a cuticle collagen gene in XXXX .

answer: @entity0


abstract: PURPOSE: The dose-proportionality of pharmacokinetics of an iodinated contrast medium, @entity2 , encapsulated into liposomes was investigated. METHODS: Following single intravenous administration of 150 mg @entity1 /kg (potential diagnostic dose) and a five-fold higher dose in @entity0 the pattern of elimination was studied until 7 d and the blood concentrations were monitored up to 72 h after administration. The @entity1 concentration in the liver was calculated on the basis of the blood concentration and related to the concentration measured in the @entity0 liver. RESULTS: The dose-normalized blood concentration-time profiles of the encapsulated @entity1 were not superimposable. Contrary to the low dose a steady-state concentration of 2.8 mg @entity1 /mL was observed in blood for 60 min after the high dose administration indicating a saturation of the liposomal liver uptake. For both doses the elimination of @entity1 occurred predominantly via the kidneys and was complete 7 d after administration. The dose-normalized amounts of @entity1 excreted with the urine were similar for both dose groups. From the blood data it was calculated that doses up to about 300 mg @entity1 /kg should result in a dose-proportional increase of liposomal liver uptake before saturation occurs. This was confirmed by the measured @entity1 liver concentrations after increasing the doses stepwise from 150 to 750 mg @entity1 /kg. CONCLUSIONS: In @entity0 for the dose range 150 to 750 mg @entity1 /kg @entity2 liposomes reveal dose-dependent pharmacokinetics due to a saturation in liver uptake which occurs for doses of 300 mg @entity1 /kg corresponding to 300 mg lipid/kg onwards.

title: Pharmacokinetics of XXXX liposomes in @entity0 .

answer: @entity2


abstract: PURPOSE: The dose-proportionality of pharmacokinetics of an iodinated contrast medium, @entity2 , encapsulated into liposomes was investigated. METHODS: Following single intravenous administration of 150 mg @entity1 /kg (potential diagnostic dose) and a five-fold higher dose in @entity0 the pattern of elimination was studied until 7 d and the blood concentrations were monitored up to 72 h after administration. The @entity1 concentration in the liver was calculated on the basis of the blood concentration and related to the concentration measured in the @entity0 liver. RESULTS: The dose-normalized blood concentration-time profiles of the encapsulated @entity1 were not superimposable. Contrary to the low dose a steady-state concentration of 2.8 mg @entity1 /mL was observed in blood for 60 min after the high dose administration indicating a saturation of the liposomal liver uptake. For both doses the elimination of @entity1 occurred predominantly via the kidneys and was complete 7 d after administration. The dose-normalized amounts of @entity1 excreted with the urine were similar for both dose groups. From the blood data it was calculated that doses up to about 300 mg @entity1 /kg should result in a dose-proportional increase of liposomal liver uptake before saturation occurs. This was confirmed by the measured @entity1 liver concentrations after increasing the doses stepwise from 150 to 750 mg @entity1 /kg. CONCLUSIONS: In @entity0 for the dose range 150 to 750 mg @entity1 /kg @entity2 liposomes reveal dose-dependent pharmacokinetics due to a saturation in liver uptake which occurs for doses of 300 mg @entity1 /kg corresponding to 300 mg lipid/kg onwards.

title: Pharmacokinetics of @entity2 liposomes in XXXX .

answer: @entity0


abstract: This study was designed to measure early changes in myocardial perfusion after acute @entity3 , and to examine the relationships among blood flow, @entity2 , and magnetic relaxation times of ex vivo myocardial tissue. In ten @entity1 , the left anterior descending coronary artery was occluded for 4 hours prior to sacrifice of the animals. Regional myocardial blood flow was measured using radiolabeled microspheres (15 micron), which were injected into the left atrium 5 minutes prior to sacrifice. Multiple subendocardial tissue samples from the left ventricular free wall were obtained for measurement of magnetic relaxation times, percent water content and tissue radioactivity. Mild, moderate, and severe @entity0 were defined as reductions in myocardial blood flow to 30% to 50%, 15% to 30%, and less than or equal to 15% of control, respectively. Myocardial water content was increased with mild @entity0 (79.6 +/- 0.7%), moderate @entity0 (79.9 +/- 0.4%), and severe @entity0 (80.3 +/- 0.6%), all P less than .005 vs. control. T1 relaxation times rose with mild (544 +/- 10 msec, P less than .005 vs. control), moderate (543 +/- 11 msec, P less than .005 vs. control), and severe @entity0 (574 +/- 10 msec, P less than .001 vs. control). T2 relaxation times behaved in a similar manner, being prolonged in the mildly, moderately, and severely @entity0 groups (38.3 +/- 0.3, 38.1 +/- 0.3 and 38.2 +/- 0.3 msec, respectively; all P less than .001 vs. control).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Regional myocardial blood flow, edema formation, and magnetic relaxation times during acute myocardial ischemia in the XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity2 is the most frequent @entity0 . With over 90 genes and 110 loci causally implicated in @entity3 , it is phenotypically and genetically heterogeneous. Here, we investigate the genetic etiology of @entity2 in four families of Iranian origin segregating @entity3 ( @entity3 ). We used a combination of linkage analysis, homozygosity mapping, and a targeted genomic enrichment platform to simultaneously screen 90 known @entity2 -causing genes for pathogenic variants. Variant segregation was confirmed by Sanger sequencing. Linkage analysis and homozygosity mapping showed segregation with the @entity7 locus on chromosome 10 in two families. Targeted genomic enrichment with massively parallel sequencing identified causal variants in @entity6 : a homozygous missense variant ( @entity8 ) in one family and compound heterozygosity for missense ( @entity9 ) and nonsense ( @entity10 ) variants in the second family. Screening of two additional families identified two more variants: ( @entity11 ) and ( @entity12 ). Variant segregation with the @entity1 phenotype was confirmed in all families by Sanger sequencing. The missense variants are predicted to be deleterious, and the two nonsense mutations produce null alleles. This report is the first to show that mutations in @entity6 cause @entity3 , a finding that offers addition insight into the @entity4 interactome. We also describe a novel likely disease-causing mutation in @entity5 and illustrate the complexity associated with gene identification in diseases that exhibit large genetic and phenotypic heterogeneity.    2015 Wiley Periodicals, Inc.

title: @entity6 and XXXX : More than just a modifier.

answer: @entity1


abstract: UNASSIGNED: @entity2 is the most frequent @entity0 . With over 90 genes and 110 loci causally implicated in @entity3 , it is phenotypically and genetically heterogeneous. Here, we investigate the genetic etiology of @entity2 in four families of Iranian origin segregating @entity3 ( @entity3 ). We used a combination of linkage analysis, homozygosity mapping, and a targeted genomic enrichment platform to simultaneously screen 90 known @entity2 -causing genes for pathogenic variants. Variant segregation was confirmed by Sanger sequencing. Linkage analysis and homozygosity mapping showed segregation with the @entity7 locus on chromosome 10 in two families. Targeted genomic enrichment with massively parallel sequencing identified causal variants in @entity6 : a homozygous missense variant ( @entity8 ) in one family and compound heterozygosity for missense ( @entity9 ) and nonsense ( @entity10 ) variants in the second family. Screening of two additional families identified two more variants: ( @entity11 ) and ( @entity12 ). Variant segregation with the @entity1 phenotype was confirmed in all families by Sanger sequencing. The missense variants are predicted to be deleterious, and the two nonsense mutations produce null alleles. This report is the first to show that mutations in @entity6 cause @entity3 , a finding that offers addition insight into the @entity4 interactome. We also describe a novel likely disease-causing mutation in @entity5 and illustrate the complexity associated with gene identification in diseases that exhibit large genetic and phenotypic heterogeneity.    2015 Wiley Periodicals, Inc.

title: XXXX and @entity1 : More than just a modifier.

answer: @entity6


abstract: UNASSIGNED: @entity2 is a disease whereby an injury in the wall of the aorta leads to the creation of a true lumen and a false lumen separated by an intimal flap which may contain multiple communicating tears between the lumina. It has a high associated morbidity and mortality, but at present, the timing of surgical intervention for stable type B dissections remains an area of debate. Detailed knowledge of haemodynamics may yield greater insight into the long-term outcomes for dissection @entity0 by providing a greater understanding of pressures, wall shear stress and velocities in and around the dissection. In this paper, we aim to gather further insight into the complex haemodynamics in @entity2 using medical imaging and computational fluid dynamics modelling. Towards this end, several computer models of the aorta of a @entity0 presenting with an acute Stanford type B dissection were created whereby morphometric parameters related to the dissection septum were altered, such as removal of the septum, and the variation of the number of connecting tears between the lumina. @entity0 -specific flow data acquired using 2D PC-MRI in the ascending aorta were used to set the inflow boundary condition. Coupled zero-dimensional (Windkessel) models representing the distal vasculature were used to define the outlet boundary conditions and tuned to match 2D PC-MRI flow data acquired in the descending aorta. Haemodynamics in the dissected aorta were compared to those in an equivalent 'healthy aorta', created by virtually removing the intimal flap (septum). Local regions of increased velocity, pressure, wall shear stress and alterations in flow distribution were noted, particularly in the narrow true lumen and around the primary entry tear. The computed flow patterns compared favourably with those obtained using 4D PC-MRI. A lumped-parameter heart model was subsequently used to show that in this case there was an estimated 14  % increase in left @entity1 work with the onset of dissection. Finally, the effect of secondary connecting tears (i.e. those excluding the primary entry and exit tears) was also studied, revealing significant haemodynamic changes when no secondary tears are included in the model, particularly in the true lumen where increases in flow over [Formula: see text] and drops in peak pressure of 18  % were observed.

title: Multi-modality image-based computational analysis of haemodynamics in XXXX .

answer: @entity2


abstract: UNASSIGNED: Recent data indicate that serum @entity5 ( @entity3 ) levels are @entity4 . However, there is no report in the literature on circulating @entity5 levels in @entity1 . In this pilot study, we measured serum @entity5 levels in 11 pregnant @entity0 with pregestational @entity1 , 38 @entity0 with @entity7 , and 40 healthy pregnant @entity0 with ELISA. Plasma @entity2 levels, serum insulin concentrations, HbA1c values, and the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) index were also determined. According to our results, serum @entity5 concentrations were significantly higher in @entity0 with @entity1 than in healthy pregnant @entity0 . In addition, pregestational @entity1 @entity0 had significantly higher @entity5 levels than those with @entity7 . Furthermore, in the group of @entity0 with @entity1 , serum @entity5 levels showed a significant positive correlation with @entity6 c values. However, there was no other relationship between clinical features and metabolic parameters of the study subjects and their serum @entity5 levels in either study group. In conclusion, we demonstrated for the first time in the literature that serum @entity5 levels are increased and correlate with HbA1c values in @entity0 with @entity1 . Nevertheless, further studies are needed to determine whether circulating @entity5 plays a causative role in the pathogenesis of @entity7 or elevated serum @entity5 levels are only consequences of the disease.

title: Increased circulating heat shock protein 70 ( XXXX ) levels in @entity1 : a pilot study.

answer: @entity3


abstract: UNASSIGNED: Recent data indicate that serum @entity5 ( @entity3 ) levels are @entity4 . However, there is no report in the literature on circulating @entity5 levels in @entity1 . In this pilot study, we measured serum @entity5 levels in 11 pregnant @entity0 with pregestational @entity1 , 38 @entity0 with @entity7 , and 40 healthy pregnant @entity0 with ELISA. Plasma @entity2 levels, serum insulin concentrations, HbA1c values, and the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) index were also determined. According to our results, serum @entity5 concentrations were significantly higher in @entity0 with @entity1 than in healthy pregnant @entity0 . In addition, pregestational @entity1 @entity0 had significantly higher @entity5 levels than those with @entity7 . Furthermore, in the group of @entity0 with @entity1 , serum @entity5 levels showed a significant positive correlation with @entity6 c values. However, there was no other relationship between clinical features and metabolic parameters of the study subjects and their serum @entity5 levels in either study group. In conclusion, we demonstrated for the first time in the literature that serum @entity5 levels are increased and correlate with HbA1c values in @entity0 with @entity1 . Nevertheless, further studies are needed to determine whether circulating @entity5 plays a causative role in the pathogenesis of @entity7 or elevated serum @entity5 levels are only consequences of the disease.

title: Increased circulating heat shock protein 70 ( @entity3 ) levels in XXXX : a pilot study.

answer: @entity1


abstract: BACKGROUND: @entity0 with @entity1 are at increased risk of serious @entity3 related complications with higher rates of hospitalization and mortality than healthy cohorts. Although annual vaccination against @entity2 is recommended, vaccination rates among @entity1 @entity0 are apparently low. The reasons for the low compliance to @entity3 vaccine and the @entity3 vaccination rate among @entity1 @entity0 have not been studied in detail yet. @entity0 AND METHODS: From July 1, 2013 to October 31, 2013, 444 @entity0 treated in the outpatient departments of the Clinical Division of Oncology and the Clinical Division of Haematology and Haemostaseology of the General Hospital Vienna participated in a survey on different aspects of @entity3 vaccination. RESULTS: In total, only 80 out of 444 @entity0 (18%) had received @entity3 vaccination in the previous year. The @entity3 vaccination rate was higher amongst @entity0 with haematological @entity1 (22%) compared to @entity0 with solid @entity1 (13%). Higher age was significantly associated with a higher probability for being vaccinated. Collecting information about @entity3 vaccination primarily from media or the internet was not significantly associated with @entity3 vaccination status. Information through a medical consultation or a recommendation by the attending physician resulted in significant higher @entity3 vaccination coverage rates. Only 199 out of the 444 @entity0 (44.8%) were informed by a physician about @entity3 vaccination and only 18 out of 337 @entity0 (5.3%) with a diagnosis of a @entity1 were informed by their treating oncologist. The main reasons for @entity3 vaccination denial were concerns about interaction with the @entity1 and potential side-effects. CONCLUSION: Information about @entity3 vaccination during a medical consultation and a clear recommendation by the attending physician are highly predictive for acceptance of @entity3 vaccination. Increased awareness among physicians, especially oncologists is of utmost importance to effectively improve IVR in @entity0 with @entity1 .

title: Influenza vaccination perception and coverage among @entity0 with XXXX .

answer: @entity1


abstract: BACKGROUND: @entity0 with @entity1 are at increased risk of serious @entity3 related complications with higher rates of hospitalization and mortality than healthy cohorts. Although annual vaccination against @entity2 is recommended, vaccination rates among @entity1 @entity0 are apparently low. The reasons for the low compliance to @entity3 vaccine and the @entity3 vaccination rate among @entity1 @entity0 have not been studied in detail yet. @entity0 AND METHODS: From July 1, 2013 to October 31, 2013, 444 @entity0 treated in the outpatient departments of the Clinical Division of Oncology and the Clinical Division of Haematology and Haemostaseology of the General Hospital Vienna participated in a survey on different aspects of @entity3 vaccination. RESULTS: In total, only 80 out of 444 @entity0 (18%) had received @entity3 vaccination in the previous year. The @entity3 vaccination rate was higher amongst @entity0 with haematological @entity1 (22%) compared to @entity0 with solid @entity1 (13%). Higher age was significantly associated with a higher probability for being vaccinated. Collecting information about @entity3 vaccination primarily from media or the internet was not significantly associated with @entity3 vaccination status. Information through a medical consultation or a recommendation by the attending physician resulted in significant higher @entity3 vaccination coverage rates. Only 199 out of the 444 @entity0 (44.8%) were informed by a physician about @entity3 vaccination and only 18 out of 337 @entity0 (5.3%) with a diagnosis of a @entity1 were informed by their treating oncologist. The main reasons for @entity3 vaccination denial were concerns about interaction with the @entity1 and potential side-effects. CONCLUSION: Information about @entity3 vaccination during a medical consultation and a clear recommendation by the attending physician are highly predictive for acceptance of @entity3 vaccination. Increased awareness among physicians, especially oncologists is of utmost importance to effectively improve IVR in @entity0 with @entity1 .

title: Influenza vaccination perception and coverage among XXXX with @entity1 .

answer: @entity0


abstract: The present study evaluated the effects of single-dose @entity3 in protecting @entity1 against fever associated with transportation using 48 healthy Thoroughbreds. All @entity1 were premedicated with interferon-a (0.5 U/kg, sublingually, every 24 hr) for 2 days before transportation and on the day of transportation. @entity1 were randomly assigned to receive @entity3 (2 mg/kg, IV, once; MRFX group), @entity2 (5 mg/kg, IV, once; ERFX group) or saline (0.9% @entity0 ) solution (10 ml, IV, once; control group)  <=1 hr before being transportation. Each group contained 16 @entity1 (8 males, 8 females). @entity1 were transported 1,210 km using commercial vans over the course of approximately 26 hr. Clinical examinations and hematologic analyses were performed on all @entity1 both before and after transportation. Post-transportation neutrophil to lymphocyte ratios were significantly lower in @entity1 in the MRFX group compared with the control horses. The serum amyloid A levels were significantly lower in @entity1 in the MRFX group and ERFX group compared with the control @entity1 . Regarding the post-transportation rectal temperatures, fever was detected in 0 @entity1 and 1 @entity1 in the MRFX and ERFX groups, respectively, whereas fevers exceeding 39.1  C were detected in 2 @entity1 in the control group. Additionally, the number of essential post-transportation treatments provided by veterinarians was reduced 3-fold in the MRFX and ERFX groups compared with the saline group. MRFX provided ERFX-like protection against fever associated with long-distance transportation, yielding significantly better protection than saline. Administration of MRFX just before transportation deserves a further study for efficacy in preventing @entity1 fever associated with transportation.

title: Effects of pre-shipping XXXX administration on fever and blood properties in healthy Thoroughbreds transported a long distance.

answer: @entity3


abstract: STUDY OBJECTIVES: Sleep disordered @entity5 (SDB) is a frequent comorbidity in @entity2 @entity0 . SDB is one of the independent risk factors for @entity3 . Conversely, @entity2 may contribute to SDB onset or aggravate premorbid SDB. Multiple mechanisms underlying SDB might be responsible for the development of @entity2 . The aim of this study was to compare polysomnographic, clinical, and laboratory characteristics of wake-up (WUS) and non-wake-up acute @entity3 (NWUS). METHODS: We prospectively enrolled 88 @entity0 with acute @entity3 . Clinical characteristics of the population were recorded on admission, and blood samples were obtained in the fasting condition following morning. SDB was assessed using standard overnight polysomnography in the acute phase of the @entity2 . RESULTS: WUS were present in 16 @entity0 (18.2%), and NWUS in 72 @entity0 (81.8%). In WUS compared to NWUS, we observed significantly higher values of @entity1 index (24.8 vs. 7.6, p = 0.007), desaturation index ([DI] 26.9 vs. 8.8, p = 0.005), arousal index (22.6 vs. 13.1, p = 0.035), diastolic blood pressure (91.6 mm Hg vs. 85.2 mm Hg, p = 0.039), @entity4 levels ([TG] 1.9 mmol/L vs. 1.2 mmol/L, p = 0.049), and significantly lower levels of D-dimer (0.4  g/L vs. 0.7  g/L, p = 0.035). DI (CI: 1.003-1.054, p = 0.031) and TG (CI: 1.002-1.877, p = 0.049) were the only independent variables significantly associated with WUS in binary logistic regression model. CONCLUSION: Although the design of our study does not prove the causal relationship between SDB and WUS, higher severity of SDB parameters in WUS supports this hypothesis.

title: Association of Sleep Disordered Breathing with Wake-Up Acute XXXX : A Full Polysomnographic Study.

answer: @entity3


abstract: 1. @entity0 costal cartilage was found to begin to calcify normally when the @entity0 weigh 35-45g. 2. The cartilage is suggested as a model for the study in vivo of mechanisms concerned with normal @entity2 . 3. The model was tested by studying the incorporation of @entity3 into the mineral deposited in the tissue. 4. The percentage of inorganic material in cartilage rose from approx. 3% of the dry weight in the uncalcified tissue to 62% in the tissue from @entity0 weighing 300g. 5. Mineral deposited had a @entity1 / @entity5 molar ratio of 1.65. 6. After the oral administration of @entity6 to @entity0 , @entity3 was incorporated into cartilage mineral. 7. The concentration of @entity3 in cartilage ash increased rapidly with @entity2 and the mineral became more highly fluoridated than the corresponding rib bone. 8. Fluoridated mineral showed a marked decrease in @entity4 concentration.

title: A model for studying the initiation of normal XXXX in vivo.

answer: @entity2


abstract: UNASSIGNED: While early stages of @entity3 are usually cured by surgery, metastatic @entity3 are difficult to treat because the widely available options have low response rates. Careful and precise diagnosis and staging are essential to determine @entity0 's risk and to select appropriate treatments. Fortunately, the recent progress in immunotherapy is very encouraging. In this context, it is important to characterize the intratumoral infiltration of immune cells in each @entity0 , which is however not done routinely due to the lack of standardized methods. In this study, we used Fourier transform infrared (FTIR) imaging combined with multivariate statistical analyses to investigate non-metastatic and metastatic lymph nodes from @entity3 @entity0 . Our results show that the different cell types have different infrared spectral features allowing automated identification of these cell types. High recognition rates were obtained using a supervised partial least square discriminant analysis (PLS-DA) model. @entity3 cells were recognized with 87.1% sensitivity and 85.7% specificity, showing that FTIR spectroscopy has similar detection power as immunohistochemistry. Besides, FTIR imaging could also distinguish lymphocyte subpopulations (B and T cells). Finally, we investigated the changes in lymphocytes due to the presence of @entity1 . Interestingly, specific features of spectra of lymphocytes present in metastatic or @entity2 -free lymph nodes could be evidenced by PCA. A PLS-DA model was capable of predicting whether lymphocytes originated from invaded or non-invaded lymph nodes. These data demonstrate that FTIR imaging is capable to distinguish known and also novel biological features in @entity0 tissues, with potential practical relevance for histopathological diagnosis and biomarker assessment.

title: Identification of XXXX cells and lymphocyte subpopulations in lymph node @entity1 by FTIR imaging histopathology.

answer: @entity3


abstract: UNASSIGNED: While early stages of @entity3 are usually cured by surgery, metastatic @entity3 are difficult to treat because the widely available options have low response rates. Careful and precise diagnosis and staging are essential to determine @entity0 's risk and to select appropriate treatments. Fortunately, the recent progress in immunotherapy is very encouraging. In this context, it is important to characterize the intratumoral infiltration of immune cells in each @entity0 , which is however not done routinely due to the lack of standardized methods. In this study, we used Fourier transform infrared (FTIR) imaging combined with multivariate statistical analyses to investigate non-metastatic and metastatic lymph nodes from @entity3 @entity0 . Our results show that the different cell types have different infrared spectral features allowing automated identification of these cell types. High recognition rates were obtained using a supervised partial least square discriminant analysis (PLS-DA) model. @entity3 cells were recognized with 87.1% sensitivity and 85.7% specificity, showing that FTIR spectroscopy has similar detection power as immunohistochemistry. Besides, FTIR imaging could also distinguish lymphocyte subpopulations (B and T cells). Finally, we investigated the changes in lymphocytes due to the presence of @entity1 . Interestingly, specific features of spectra of lymphocytes present in metastatic or @entity2 -free lymph nodes could be evidenced by PCA. A PLS-DA model was capable of predicting whether lymphocytes originated from invaded or non-invaded lymph nodes. These data demonstrate that FTIR imaging is capable to distinguish known and also novel biological features in @entity0 tissues, with potential practical relevance for histopathological diagnosis and biomarker assessment.

title: Identification of @entity3 cells and lymphocyte subpopulations in lymph node XXXX by FTIR imaging histopathology.

answer: @entity1


abstract: BACKGROUND: The aim was to assess the impact of a one-to-one 30-min individualized interaction per day on the behavior and quality of life of care-dependent residents with @entity1 . METHODS: In a pre-/post-test study, 15 care-dependent residents with @entity1 (mean age 88.8 years, 86.7% @entity0 ) were included. Resident behavior was measured using video observation and quality of life using Qualidem. Health care professionals (n = 13) and direct relatives (n = 4) were interviewed about the effect of the intervention. The effect of the intervention was analyzed using the Friedman analysis of variance. RESULTS: The video observation showed that maintaining eye contact, touching, responding to speaking, tracking observable stimuli and asking questions about the activity significantly increased during the intervention. These findings were supported by interviews with nurses who described experiences of making @entity0 -to- @entity0 contact with the residents. No significant overall changes were found in quality of life. These findings were partially supported by interviews with health care professionals and relatives as some perceived effects beyond the 30-min intervention. CONCLUSIONS: Interaction offered on a one-to-one basis tailored to individual preferences significantly improved positive interactive behavior of care-dependent residents with @entity1 during the intervention. Surveys revealed no significant overall effect of the intervention. The interviews indicated there might be effects beyond the intervention for some residents.

title: The impact of individualized interaction on the quality of life of elderly dependent on care as a result of XXXX : a study with a pre-post design.

answer: @entity1


abstract: @entity7 and @entity4 are type II topoisomerase enzymes that have important but distinct roles in DNA replication and RNA transcription. Recently, @entity4 has been implicated in the transcription of long genes in particular that play crucial roles in neural development and are susceptible to mutations contributing to neurodevelopmental conditions such as @entity3 and @entity1 . This study maps their expression in the early foetal @entity0 telencephalon between 9 and 12 post-conceptional weeks. @entity7 immunoreactivity was restricted to cell nuclei of the @entity2 (GE), including the ventricular zone and subventricular zone (SVZ) closely matching expression of the proliferation marker KI67. Comparison with sections immunolabelled for @entity6 , a medial GE (MGE) marker, and @entity5 , a cortical progenitor cell and lateral GE (LGE) marker, revealed that @entity7 -expressing cells were more abundant in MGE than the LGE. In the cortex, @entity4 is expressed in cell nuclei in both proliferative (SVZ) and post-mitotic compartments (intermediate zone and cortical plate) as revealed by comparison with immunostaining for @entity5 and the post-mitotic neuron marker @entity8 . However, co-expression with KI67 was rare. In the GE, @entity4 was also expressed by proliferative and post-mitotic compartments. In situ hybridisation studies confirmed these patterns of expression, except that @entity7 mRNA is restricted to cells in the G2/M phase of division. Thus, during early development, @entity7 is likely to have a role in cell proliferation, whereas @entity4 is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

title: Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal XXXX telencephalon.

answer: @entity0


abstract: Glossina pallidipes, G. f. fuscipes and G. brevipalpis in Stages I and II of hunger were caught from Bukunya and Buyundo villages in south-east Uganda during the period December 1969 to February 1971, and the origins of their blood meals identified. G. pallidipes fed mainly on bovids in the two villages; bushbuck was the most favoured host (44.9% of all blood feeds) though in Buyundo buffalo provided a significant alternative (20.8%). G. f. fuscipes frequently fed on bovids (75.6%), particularly bushbuck (46.7%), but it had a wider range of acceptable hosts. In both villages, G. brevipalpis took most of its blood meals from bushpig (45.5%), bovids (25.6%) and @entity4 (28.5%). The feeding patterns of the three tsetse species during different months of the study period showed only small variations, and such differences were due probably to variations in the availability of the hosts. Examination of the relationships between trypanosome infection rates and natural hosts of the three vector species showed that the vivax-type infections originated from bovids, possibly bushbuck, while the congolense-type trypanosome came from bovids as well as bushpig. @entity4 probably had no trypanosome infections. There was a positive correlation between the trypanosome infection rates in the tsetse and the increasing mean maximum temperatures. In this region of Uganda, there was continuous transmission of pathogenic trypanosomes by the three tsetse species among their natural hosts; when present, the vectors' adventitious hosts became exposed to a high risk from the diseases. @entity0 - @entity1 contact during different months was impersonal, but high and sporadic. This is a high endemic region for @entity0 @entity3 . Also, the introduced @entity2 succumb to the diseases very rapidly. The overall results are discussed in terms of the concept of challenge of African @entity3 .

title: Studies on Glossina pallidipes, G. fuscipes fuscipes and G. brevipalpis in terms of the epidemiology and epizootiology of XXXX in south-eastern Uganda.

answer: @entity3


abstract: UNASSIGNED: @entity2 ( @entity2 ) is the most common @entity3 and contributes to increased morbidity and compromised cardiovascular outcomes. @entity1 are common but rarely reported and addressed by primary health providers. An American Academy of Sleep Medicine task force (2015) released quality measures for the care of adult @entity0 with @entity2 ; the first outcome is improved detection and categorization of @entity2 symptoms and severity to promote assessment and diagnosis of the disorder. This state of the science integrative review aimed to evaluate the screening and assessment for @entity2 in primary care settings including the psychometric properties of @entity2 screening measures. Studies that met inclusion criteria were fourteen non-experimental and three experimental designs. @entity2 screening measurements (Berlin questionnaire, @entity1 scale, STOP Bang) with extensive validation studies were examined. Conclusions are that the current practice model of screening and assessment for @entity2 in primary care is fragmented and ineffective. Primary care providers encounter @entity0 with @entity2 symptoms but do not routinely screen, assess, or refer to a sleep specialist. More psychometric research is needed for the @entity2 screening measurements in primary care. The results of these studies can be translated into practice to increase detection of @entity2 .

title: Screening and assessment for obstructive XXXX in primary care.

answer: @entity3


abstract: BACKGROUND: Although laparoscopic spleen-preserving distal pancreatectomy surgery is more and more popular, the reports about the en bloc technique used for @entity3 were still rare. The aim of our study was to illustrate the detail of the spleen-preserving en bloc technique as well as the short-term and long-term outcomes. METHODS: The detail of the en bloc technique with pictures was described. The prognosis of the successive 23 cases that underwent the laparoscopic distal pancreatectomy (LDP) surgery was evaluated. RESULTS: There were 17 cases that underwent spleen-preserving LDP while six cases underwent spleen-resecting LDP. The average surgery time was 203        54  min, and the average @entity2 volume was 208        264  ml; one case transferred to open surgery because of severe @entity4 . The complication rate was 47  % (n   =   8) shortly after surgery. @entity5 rate was 41  % (n   =   7). No lethal case occurred. The average diameter of the @entity1 was 32        12  mm. The average number of the lymph nodes obtained was 19.8        9.3. All the cutting edges were negative. Survival rates of the @entity0 after 1, 3, and 5  years are 64.7, 52.9, and 41.2  %, respectively. These records showed no statistical significance compared with spleen-resecting LDP and open distal pancreatectomy (ODP) surgeries. CONCLUSIONS: The en bloc spleen-preserving LDP can be performed by experienced surgeons. This surgery has good short-term and long-term outcomes.

title: The detail of the en bloc technique and prognosis of spleen-preserving laparoscopic distal pancreatectomy for XXXX .

answer: @entity3


abstract: INTRODUCTION: @entity1 increases the risk of both early and late @entity2 . Antiepileptic prophylaxis reduces early @entity2 , but their use beyond 1   week does not prevent the development of @entity3 . Furthermore, prolonged prophylaxis exposes @entity0 to side effects of the drugs and has occupational implications. The American Academy of Neurology recommends that antiepileptic prophylaxis should be started for @entity0 with severe @entity1 and discontinued after 1   week. An audit is presented here that investigates the use of prophylaxis in a cohort of military @entity0 admitted to the UK Defence Medical Rehabilitation Centre (DMRC). METHODS: Data were collected and analysed retrospectively from electronic and paper records between February 2009 and August 2012. The timing and duration of antiepileptic drug use and the incidence of @entity2 were recorded. RESULTS: During the study period, 52 @entity0 with severe @entity1 were admitted to the rehabilitation centre: 25 @entity0 (48%) were commenced on prophylaxis during the first week following injury while 27 (52%) did not receive prophylaxis. Only one @entity0 (2%) received prophylaxis for the recommended period of 1   week, 22 @entity0 (42%) received prophylaxis for longer than 1   week with a mean duration of 6.2   months. Two @entity0 (4%) had @entity3 and started on treatment at DMRC. CONCLUSIONS: The use of antiepileptic prophylaxis varies widely and is generally inconsistent with evidence-based guidance. This exposes some @entity0 to a higher risk of early @entity2 and others to unnecessary use of antiepileptics. Better implementation of prophylaxis is required.

title: Antiepileptic prophylaxis following severe XXXX within a military cohort.

answer: @entity1


abstract: OBJECTIVE: @entity8 ( @entity8 ) of the temporal lobe often present with @entity4 . Surgical resection of these lesions can offer durable @entity4 control. There is, however, no universally accepted methodology for assessing and surgically treating these @entity0 . We propose an algorithm to maximize positive surgical outcomes ( @entity4 control) while minimizing post-surgical @entity1 . METHODS: A retrospective review of 34 @entity0 who underwent @entity3 surgery for radiographically proven temporal lobe @entity8 was conducted. @entity0 underwent a relatively standard work-up for @entity4 localization. In @entity0 with @entity6 ( @entity6 ), a complete resection of the epileptogenic zone was performed including amygdalo-hippocampectomy in addition to a lesionectomy if not contraindicated by pre-operative work-up. @entity0 with neocortical @entity3 underwent intraoperative electrocorticography (ECoG)-guided lesionectomy. RESULTS: @entity4 -free rate for mesial and neocortical (anterior, lateral, and basal) location was 90 vs. 83  %, respectively. Complete resection of the lesion, irrespective of location, was statistically significant for @entity4 control (p   =   0.018). There was no difference in @entity4 control based on disease duration or location (p   >   0.05). @entity0 with mesial temporal @entity8 who presented with @entity6 were presumed to also have @entity7 ( @entity7 ), or dual pathology. These @entity0 underwent routine resection of the mesial structures. Interestingly, @entity0 who had @entity6 and basal (neocortical) lesions who underwent a mesial resection for suspected @entity7 were found not to have dual pathology. CONCLUSIONS: @entity0 with temporal lobe @entity8 should be offered resection for durable @entity4 control, prevention of secondary epileptogenic foci, and elimination of @entity5 risk. The preoperative work-up should follow a team approach. Surgical intervention should include complete lesionectomy in all cases. Intra or extra-operative ECoG for @entity2 may be beneficial. Management of mesial temporal CCMs (archicortex) should consider resection of a well-defined epileptogenic zone (including mesial structures) due to high probability of pathologically proven @entity7 . The use of this treatment algorithm is useful for the education and treatment of these @entity0 .

title: XXXX and cavernous malformations: surgical strategies and long-term outcomes.

answer: @entity6


abstract: INTRODUCTION: Complex embryological processes form the head and neck of @entity0 . It is not flawless; remnants lead to sinuses or cysts, commonly in the head and neck region. CASE PRESENTATION: We present the a case of an 8-year-old @entity0 , a primary school pupil, from rural Kenya with chronic cough, wheezing, difficulty in breathing and @entity2 on exertion. He was treated with antibiotics and antitubercular drugs without improvement prior to referral to our hospital. A computed tomography scan of his chest revealed a superior mediastinal mass extending into his neck. A diagnosis of a brachial cleft cyst was made and our @entity0 underwent a successful excision of the mass through a median strenotomy and neck dissection. CONCLUSIONS: @entity3 are common, accounting for 20% of pediatric neck masses. Usually they present as a neck mass but in our case it presented as a mediastinal mass, which is a very rare clinical presentation. Surgical excision is the mainstay of treatment. To the surgeon, the embryology and anatomy should be absolutely clear as dissection may be challenging due to the close proximity and variable course of the cystic stalk to @entity1 .

title: XXXX : an unusual cause of a mediastinal mass: a case report.

answer: @entity3


abstract: UNASSIGNED: Background: Severe @entity2 with @entity5 (SFTS) is a newly emerging @entity1 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity0 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity4 +/total lymphocytes, @entity4 + @entity6 +/ @entity4 + cells and @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity4 +/total lymphocytes and @entity4 + @entity6 +/ @entity4 + cells was observed in @entity0 with SFTS compared with healthy controls. In contrast, the percentage of @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in the @entity0 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity0 with SFTS at different stages. The results showed that the proportion of @entity4 +/total lymphocytes and @entity4 + @entity6 +/ @entity4 + cells in the non-severe group was prominently higher than that in @entity0 with severe SFTS. Conversely, the proportion of @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity0 with SFTS. Our investigation suggested that the proportions of @entity4 +/total lymphocytes and @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.

title: Circulating regulatory T cells in @entity0 with severe XXXX with @entity5 .

answer: @entity2


abstract: UNASSIGNED: Background: Severe @entity2 with @entity5 (SFTS) is a newly emerging @entity1 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity0 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity4 +/total lymphocytes, @entity4 + @entity6 +/ @entity4 + cells and @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity4 +/total lymphocytes and @entity4 + @entity6 +/ @entity4 + cells was observed in @entity0 with SFTS compared with healthy controls. In contrast, the percentage of @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in the @entity0 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity0 with SFTS at different stages. The results showed that the proportion of @entity4 +/total lymphocytes and @entity4 + @entity6 +/ @entity4 + cells in the non-severe group was prominently higher than that in @entity0 with severe SFTS. Conversely, the proportion of @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity0 with SFTS. Our investigation suggested that the proportions of @entity4 +/total lymphocytes and @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.

title: Circulating regulatory T cells in @entity0 with severe @entity2 with XXXX .

answer: @entity5


abstract: UNASSIGNED: Background: Severe @entity2 with @entity5 (SFTS) is a newly emerging @entity1 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity0 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity4 +/total lymphocytes, @entity4 + @entity6 +/ @entity4 + cells and @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity4 +/total lymphocytes and @entity4 + @entity6 +/ @entity4 + cells was observed in @entity0 with SFTS compared with healthy controls. In contrast, the percentage of @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in the @entity0 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity0 with SFTS at different stages. The results showed that the proportion of @entity4 +/total lymphocytes and @entity4 + @entity6 +/ @entity4 + cells in the non-severe group was prominently higher than that in @entity0 with severe SFTS. Conversely, the proportion of @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity0 with SFTS. Our investigation suggested that the proportions of @entity4 +/total lymphocytes and @entity4 + @entity6 + @entity3 +/ @entity4 + @entity6 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.

title: Circulating regulatory T cells in XXXX with severe @entity2 with @entity5 .

answer: @entity0