abstract: OBJECTIVE: The maximal diameter of an @entity2 ( @entity2 ) and the change in diameter over time reflect rupture risk and are used for surgical planning. However, evidence has emerged that @entity1 volume may be a better indicator of @entity2 remodeling. The purpose of this study was to assess the relationship between the volume and maximal diameter of the abdominal aorta in @entity0 with untreated @entity2 . MATERIALS AND METHODS: This was a retrospective study of 100 @entity0 with @entity2 who were followed for more than 6 months. We examined 2 sets of computed tomography images for each @entity0 , acquired >=  6 months apart. The maximal diameter and volume of the infrarenal abdominal aorta were determined by semiautomated segmentation software. RESULTS: At baseline, mean maximal infrarenal diameter was 5.1    1.0 cm and mean aortic volume was 139    72 mL. There was good correlation between the maximal diameter and aortic volume at baseline (r(2) = 0.55; P<0.001). The mean change in maximal diameter between studies was 0.2    0.3 cm and the mean volume change was 19    19 mL. However, the correlation between diameter change and volume change was modest (r(2) = 0.34; P=0.001). Most @entity0 (n = 64) had no measurable change in maximal diameter between studies ( <= 2 mm), but the change in volume was found to vary widely (-2 to 69 mL). CONCLUSION: In @entity0 with untreated @entity2 , a change in aortic volume can occur in the absence of a significant change in maximal diameter. Additional work is needed to examine the relationship between change in @entity2 volume and outcomes in this @entity0 group.

title: Aortic volume as an indicator of disease progression in @entity0 with untreated XXXX .

answer: @entity1


abstract: OBJECTIVE: The maximal diameter of an @entity2 ( @entity2 ) and the change in diameter over time reflect rupture risk and are used for surgical planning. However, evidence has emerged that @entity1 volume may be a better indicator of @entity2 remodeling. The purpose of this study was to assess the relationship between the volume and maximal diameter of the abdominal aorta in @entity0 with untreated @entity2 . MATERIALS AND METHODS: This was a retrospective study of 100 @entity0 with @entity2 who were followed for more than 6 months. We examined 2 sets of computed tomography images for each @entity0 , acquired >=  6 months apart. The maximal diameter and volume of the infrarenal abdominal aorta were determined by semiautomated segmentation software. RESULTS: At baseline, mean maximal infrarenal diameter was 5.1    1.0 cm and mean aortic volume was 139    72 mL. There was good correlation between the maximal diameter and aortic volume at baseline (r(2) = 0.55; P<0.001). The mean change in maximal diameter between studies was 0.2    0.3 cm and the mean volume change was 19    19 mL. However, the correlation between diameter change and volume change was modest (r(2) = 0.34; P=0.001). Most @entity0 (n = 64) had no measurable change in maximal diameter between studies ( <= 2 mm), but the change in volume was found to vary widely (-2 to 69 mL). CONCLUSION: In @entity0 with untreated @entity2 , a change in aortic volume can occur in the absence of a significant change in maximal diameter. Additional work is needed to examine the relationship between change in @entity2 volume and outcomes in this @entity0 group.

title: Aortic volume as an indicator of disease progression in XXXX with untreated @entity1 .

answer: @entity0


abstract: OBJECTIVES: To describe the demographic characteristics, incidence of extra-abdominal hospital-acquired @entity2 and outcome of @entity0 admitted to intensive care unit (ICU) with severe acute @entity3 . STUDY DESIGN: A retrospective, observational multiple center (65 centers) analysis of prospectively acquired data. @entity0 AND METHODS: During 2 years, all consecutive admitted @entity0 to ICU for severe acute @entity3 in the centers participating in the nosocomial @entity2 surveillance network CClin Sud-Est were included. @entity0 whose ICU stay was less than 48 hours were not included. Demographic characteristics, extra-abdominal hospital-acquired @entity2 and clinical course were described. RESULTS: During the study period, 510 @entity0 were included which represented 2 % of @entity0 with a length of stay longer than 48 hours in the 65 participating ICUs. The global attack rate of extra-abdominal hospital-acquired @entity2 ( @entity1 , @entity5 , urinary tract or central @entity4 ) was 23 % in overall @entity0 and it was 33 % in the 294 mechanically ventilated @entity0 . ICU mortality was 20 % in overall @entity0 and it was 34 % in mechanically ventilated @entity0 . CONCLUSION: Severe acute @entity3 represents 2 % of ICU stay longer than 48 hours. Its clinical course is frequently complicated by hospital-acquired @entity2 and is associated with an high ICU mortality rate. This epidemiological observational study may be used for calculating sample size for future multicenter interventional therapeutic studies.

title: [Severe and acute XXXX admitted in intensive care: a prospective epidemiological multiple centre study using CClin network database].

answer: @entity3


abstract: AIM: Imprinted genes are known regulators of embryo growth. Studies from our laboratory have demonstrated that treatment of adult male @entity0 with @entity1 increased post-implantation loss at around midgestation. Expression of @entity3 ( @entity3 ), a paternally expressed imprinted gene was down-regulated in the resorbing embryos obtained at embryonic day 13. Hypomethylation of @entity3 -H19 imprint control region was observed in the resorbing embryo sires and spermatozoa obtained from @entity1 -treated @entity0 thereby suggesting that errors in imprint acquisition during spermatogenesis can result in @entity2 . The present study aims at studying the expression of other imprinted genes, besides @entity3 in the embryos sired by @entity1 -treated males. MAIN METHODS: Gene expression profiles of resorbing versus normal embryos were assessed by microarrays. Real time quantitative RT-PCR for six imprinted genes and four genes involved in cell cycle was done to validate gene expression data. The affected pathways and functions were identified in the resorbing embryos and effect on cell cycle was confirmed by flow cytometry. KEY FINDINGS: Aberrant expression of a number of imprinted genes was observed in the resorbing embryos when compared to the normal embryos at embryonic days 11 and 13. Down-regulation of Notch signaling, Wnt signaling and cell cycle pathway was observed in the resorbing embryos. SIGNIFICANCE: The study suggests that exposure of male germ cells to @entity1 during adulthood results in aberrant expression of imprinted genes and down-regulation of development associated pathways in the F(1) progeny thereby causing @entity2 .

title: Aberrant expression of imprinted genes in post-implantation XXXX embryos.

answer: @entity0


abstract: Progress in the treatment of childhood @entity5 has not equalled the advances obtained in the management of @entity3 . Two recent chemotherapy studies (i.e. @entity6 and @entity7 ), however, reported marked increase in the proportion of long-term remissions. The initial therapy of the cooperative study @entity7 consisted of two 4-week phases of intensive induction/consolidation with 7 different drugs and cranial irradiation followed by maintenance with @entity1 and @entity4 for 2 years and additional @entity2 during the first year. A total of 151 @entity0 with @entity5 were enrolled in the study from 30 centers. Of these 119 (79%) @entity0 achieved complete remission. After a median observation time of 34 (14-57) months, there have been 46 relapses. CNS was involved in 6 of these relapses. Life table analyses revealed the following probabilities after 4 1/2 years: survival: 46%; disease-free survival: 41% (total group), 52% (remission group); disease-free interval 56% (remission group). The risk of relapse appears to decrease considerably after 2 1/2 years. No risk factors for the occurrence of relapse have been identified.

title: Treatment of XXXX in @entity0 .

answer: @entity5


abstract: Progress in the treatment of childhood @entity5 has not equalled the advances obtained in the management of @entity3 . Two recent chemotherapy studies (i.e. @entity6 and @entity7 ), however, reported marked increase in the proportion of long-term remissions. The initial therapy of the cooperative study @entity7 consisted of two 4-week phases of intensive induction/consolidation with 7 different drugs and cranial irradiation followed by maintenance with @entity1 and @entity4 for 2 years and additional @entity2 during the first year. A total of 151 @entity0 with @entity5 were enrolled in the study from 30 centers. Of these 119 (79%) @entity0 achieved complete remission. After a median observation time of 34 (14-57) months, there have been 46 relapses. CNS was involved in 6 of these relapses. Life table analyses revealed the following probabilities after 4 1/2 years: survival: 46%; disease-free survival: 41% (total group), 52% (remission group); disease-free interval 56% (remission group). The risk of relapse appears to decrease considerably after 2 1/2 years. No risk factors for the occurrence of relapse have been identified.

title: Treatment of @entity5 in XXXX .

answer: @entity0


abstract: BACKGROUND: Lung @entity2 survivors are at an increased risk for recurrence and the development of secondary @entity2 and other comorbid conditions. However, little is known about @entity1 survivors' risk behaviors and the effect of these behaviors on overall health perceptions. OBJECTIVE: The purpose of this study was to describe the prevalence of health risk behaviors among @entity4 survivors and their relationship perception to overall health. METHODS: One hundred forty-two survivors of @entity4 with a minimum of 5 years disease free completed a battery of questionnaires to assess perception of health status and self-reported risk behaviors (smoking, exposure to secondhand smoke, @entity3 use) and weight before and after diagnosis. Urinary @entity5 level was used to verify smoking status, and actual height and weight were obtained to determine overweight status (body mass index, >/=25). Descriptive statistics and logistic regression were used to analyze the data. RESULTS: Seventy percent of @entity0 reported their health as good to excellent. Although 81% quit smoking after diagnosis, 13.4% continued to smoke and 28% reported exposure to secondhand smoke. Approximately half the sample (58%) drank @entity3 (16.3% quit after diagnosis) and was overweight (51%). A strong agreement between current smoking and exposure to secondhand smoke was observed. In a multivariate analysis, smoking (odds ratio [OR], 7.02; CI, 2.45 to 20.13), exposure to secondhand smoke (OR, 5.37; CI, 2.42 to 11.95), @entity3 use (OR, 9.04; CI, 3.28 to 24.92), and overweight (OR, 8.51; CI, 3.44 to 21.10) were independent predictors of perceived poor health status. CONCLUSION: Although most @entity1 survivors have made healthy lifestyle changes, a substantial proportion has not. Our findings suggest the need for multiple risk factor interventions to decrease risk behaviors and improve overall health after a @entity2 diagnosis.

title: Health perceptions and risk behaviors of XXXX survivors.

answer: @entity1


abstract: CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of French @entity1 centers (FNCLCC), the 20 French @entity1 centers, scientific societies, and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of @entity1 @entity0 . The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in @entity1 care delivery. OBJECTIVES: To develop clinical practice guidelines for the use of positron emission tomography with @entity6 in oncology according to the definitions of the Standards, Options and Recommendations project. METHODS: More than 600 articles were identified by searching Medline, web sites, and using the personal reference lists of members of the expert groups. Once the guidelines were defined, the document was submitted for review to independent reviewers (n = 82). RESULTS: The different steps in @entity0 care are studied in this report: diagnosis of the @entity2 , initial and secondary assessment of metastatic extension, evaluation of treatment response and examination for recurrence. The guidelines were developed for each @entity1 sites: bronchopulmonary and @entity1 , @entity5 , gynaecological @entity1 , @entity8 , @entity4 , @entity1 , @entity7 , soft-tissue and @entity3 , @entity1 of unknown primary site. The recommendations were made on the basis of data published up to February 2002. Systematic monitoring of the new scientific data on FDG-PET has been set up by the working group of the FNCLCC, which will ensure dissemination of the updating on its web site: www.fnclcc.fr/sor.htm.

title: [Standards, Options and Recommendations 2002 for the use of Positron Emission Tomography with XXXX (PET-FDG in cancerology (integral connection].

answer: @entity6


abstract: After greater than 60 gray (Gy) irradiation, we performed the pulmonary resection in the 18 primary @entity1 cases. The mean irradiation dose to the @entity2 was 68.2 (range 60-101) Gy, and the mean irradiation dose to the bronchial stump was 47.1 (range 0-82) Gy. Median time from end of irradiation to surgical resection was 136 (range 20-894) days. One partial resection, 9 single lobectomies, 3 double lobectomies, and 5 pneumonectomies were done. Mainly, we closed the bronchial stump by the automatic stapling device and additional hand suturing. The bronchial stump was covered in the 12 cases by the owner stalk thymus, the intercostals muscular flap, the omentum flap, and et al. The major @entity3 due to preoperative irradiation were not seen. @entity4 did not occur. Pathologically, the wall of the submucosal capillary vessels were getting thick in the @entity0 operated more than 3 months later after irradiation. In such cases with the decrease of the blood flow, the bronchial stump should be covered. The pulmonary resection after the high dose irradiation was considered to be tolerable.

title: [Resected cases with primary XXXX after preoperative high dose irradiation].

answer: @entity1


abstract: OBJECTIVE: Our aim was to evaluate the subsequent obstetrical outcome and rate of uterine @entity1 following a caesarean section before 32 weeks of gestation. @entity0 AND METHODS: A retrospective cohort study of 200 consecutive @entity0 with a prior caesarean section performed between 25 and 32 weeks were contacted by questionnaire or followed through medical charts to determine the subsequent mode of delivery. RESULTS: Two hundred caesarean section were performed between 25 and 32 weeks from January 1997 to March 2000. Thirty-nine @entity0 (19.2%) were lost to follow-up. Seventy-one @entity0 had a subsequent delivery. Thirty-two attempted vaginal birth and the success rate was 87.5%. Thirty-nine @entity0 had a subsequent caesarean. One case of uterine @entity1 occurred before labour at 31 weeks (1.4%, % IC 95% [0.25; 7.56]). CONCLUSION: After a previous caesarean delivery before 32 weeks, a trial of labour may be proposed when obstetrical conditions are optimal. However, uterine @entity1 may occur prior to labor.

title: [Obstetrical outcome and risk of uterine XXXX following a caesarean section before 32 weeks].

answer: @entity1


abstract: OBJECTIVE: To study the bone conductive @entity2 in @entity4 media with effusion (OME). METHOD: Fifty adults of OME treated in our hospital, from Mar. 2009 to Feb. 2010, were enrolled for analyzing bone conduction @entity2 (BCHL) before auripuncture and after auripuncture, the difference between which were compared in 51 ears. BCT of pre auripuncture 24 subjects, BCT of post-auripuncture 22 subjects, and BCT recovered from OME 9 subjects compared with the contralateral ear respectively. High and extend high frequency (8, 10, 12, 16 kHz) air conduction threshold (ACT) after recover from OME was compared to the normal contralateral ear in 4 adults. RESULT: BCT improved significantly after auripuncture at the frequencies (0.5-4.0 kHz), and the improvements in 4.0 kHz are more than that in 0.5 kHz significantly (P<0.05). In the unilateral OME subjects, BCT, of post auripuncture and recovered from OME, nearly recovered to the same level as the contralateral ear in most cases. While high and extend-high frequency (8, 10, 12, 16 kHz) ACT elevated in 3 of 4 @entity0 recovered from OME. CONCLUSION: Both effusion in middle ear and @entity1 result in the elevation of BCT. Elevation of BCT at regular frequencies (0.5-4.0 kHz) is frequently associated with the effusion in middle ear, while these frequencies were insensitive in the early @entity1 . The high and extend high frequency ACT elevation may be sensitive for the early @entity3 . As the disease prolonged, @entity3 of the lower frequencies (0.5-4.0 kHz) could be detected of OME @entity0 .

title: [A primary study of bone conduction XXXX in adults with @entity4 media with effusion].

answer: @entity2


abstract: OBJECTIVE: To study the bone conductive @entity2 in @entity4 media with effusion (OME). METHOD: Fifty adults of OME treated in our hospital, from Mar. 2009 to Feb. 2010, were enrolled for analyzing bone conduction @entity2 (BCHL) before auripuncture and after auripuncture, the difference between which were compared in 51 ears. BCT of pre auripuncture 24 subjects, BCT of post-auripuncture 22 subjects, and BCT recovered from OME 9 subjects compared with the contralateral ear respectively. High and extend high frequency (8, 10, 12, 16 kHz) air conduction threshold (ACT) after recover from OME was compared to the normal contralateral ear in 4 adults. RESULT: BCT improved significantly after auripuncture at the frequencies (0.5-4.0 kHz), and the improvements in 4.0 kHz are more than that in 0.5 kHz significantly (P<0.05). In the unilateral OME subjects, BCT, of post auripuncture and recovered from OME, nearly recovered to the same level as the contralateral ear in most cases. While high and extend-high frequency (8, 10, 12, 16 kHz) ACT elevated in 3 of 4 @entity0 recovered from OME. CONCLUSION: Both effusion in middle ear and @entity1 result in the elevation of BCT. Elevation of BCT at regular frequencies (0.5-4.0 kHz) is frequently associated with the effusion in middle ear, while these frequencies were insensitive in the early @entity1 . The high and extend high frequency ACT elevation may be sensitive for the early @entity3 . As the disease prolonged, @entity3 of the lower frequencies (0.5-4.0 kHz) could be detected of OME @entity0 .

title: [A primary study of bone conduction @entity2 in adults with XXXX media with effusion].

answer: @entity4


abstract: PURPOSE: The purpose of this study was to develop and validate an animal model of drug disposition in synovial fluid (SF) by comparing microdialysis with arthrocentesis using the anti-arthritic drug @entity2 ( @entity3 ). METHODS: Microdialysis probes were calibrated in vitro with the no net flux method using @entity1 synovial fluid. The probes were implanted surgically into the stifle joint space of four @entity1 and were dialyzed overnight using a portable microinfusion pump. The membrane integrity of the probes was monitored by retrodialysis using an internal standard. After an intravenous bolus of 2.5 mg/kg of @entity3 , unbound concentrations in synovial fluid, as well as total plasma concentrations, were measured by liquid chromatography tandam mass spectrometer (LC/MS/MS) in samples collected from 0 to 48 h postdose. RESULTS: The probe membrane remained intact at least 48 h after implantation. The mean probe recovery and unbound fraction of @entity3 in SF were 46.8% and 44.8%, respectively. The unbound fraction of @entity3 was 44% in synovial fluid. @entity3 penetrated into the joint space rapidly, with maximal concentrations of 6.6 microM reached at approximately 1 h postdose. The unbound @entity3 area under the curve in SF was approximately 40% of the total area under the curve in plasma. These data agree well with the previous data obtained for @entity3 using arthrocentesis. CONCLUSION: In contrast with arthrocentesis, microdialysis enables the collection of multiple serial SF samples from individual animals with minimal @entity0 and potential blood contamination. This animal model should prove valuable for studying the disposition of new antiarthritis compounds or biomarkers in SF.

title: Development of a @entity1 microdialysis model for determining synovial fluid pharmacokinetics of anti-arthritis compounds exemplified by XXXX .

answer: @entity2


abstract: PURPOSE: The purpose of this study was to develop and validate an animal model of drug disposition in synovial fluid (SF) by comparing microdialysis with arthrocentesis using the anti-arthritic drug @entity2 ( @entity3 ). METHODS: Microdialysis probes were calibrated in vitro with the no net flux method using @entity1 synovial fluid. The probes were implanted surgically into the stifle joint space of four @entity1 and were dialyzed overnight using a portable microinfusion pump. The membrane integrity of the probes was monitored by retrodialysis using an internal standard. After an intravenous bolus of 2.5 mg/kg of @entity3 , unbound concentrations in synovial fluid, as well as total plasma concentrations, were measured by liquid chromatography tandam mass spectrometer (LC/MS/MS) in samples collected from 0 to 48 h postdose. RESULTS: The probe membrane remained intact at least 48 h after implantation. The mean probe recovery and unbound fraction of @entity3 in SF were 46.8% and 44.8%, respectively. The unbound fraction of @entity3 was 44% in synovial fluid. @entity3 penetrated into the joint space rapidly, with maximal concentrations of 6.6 microM reached at approximately 1 h postdose. The unbound @entity3 area under the curve in SF was approximately 40% of the total area under the curve in plasma. These data agree well with the previous data obtained for @entity3 using arthrocentesis. CONCLUSION: In contrast with arthrocentesis, microdialysis enables the collection of multiple serial SF samples from individual animals with minimal @entity0 and potential blood contamination. This animal model should prove valuable for studying the disposition of new antiarthritis compounds or biomarkers in SF.

title: Development of a XXXX microdialysis model for determining synovial fluid pharmacokinetics of anti-arthritis compounds exemplified by @entity2 .

answer: @entity1


abstract: OBJECTIVE: To evaluate capsule endoscopy in terms of incomplete examinations and capsule retentions, to describe the characteristic of these events and to find risk factors for these events. METHODS: This retrospective and consecutive case-control study includes data of 204 capsule enteroscopy examinations in @entity0 with @entity1 , performed at the first hospital affiliated to zhejiang university medical school from June 2003 to April 2014. RESULTS: The frequency of complete examinations was 56.9%. Male gender (OR=2.48, P=0.026), @entity2 (OR=2.88, P=0.002), melena/bloody stools/OB+ (OR=3.34, P=0.009) were risk factors for an incomplete examination. Capsule retention occurred in 8.33% (n=17). The ratio of male and female was 12:5. While the average age of these @entity0 was 42.2  16.2, and the average course of disease was 52.5  46.6 months. Of the seventeen cases of retained capsules, four @entity0 chose to undergo surgery to remove the capsule for occurring symptoms of @entity3 , spontaneous passage occurred in twelve @entity0 after medical treatment, and one @entity0 still have the capsule retained after 16 months of expectation. The longest capsule retained time in @entity0 was four years. Risk factors for capsule retention was abdominal distention (OR=8.45, P=0.006). CONCLUSIONS: The majority of capsule endoscopy retention develops into spontaneous passage after medical treatment. Therefore capsule endoscopy is considered a safe procedure, although obstructive symptoms and serious complications due to capsule retention can be found in @entity0 with known @entity1 .

title: The clinical characteristic and risk of capsule incomplete and retention in XXXX .

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Low-level laser therapy (LLLT) has been shown to promote chronic wound healing in conditions of reduced microcirculation. In this preliminary study, we report the results of using LLLT to heal foot @entity2 in @entity0 with @entity1 . MATERIALS AND METHODS: Twenty-three @entity0 with a @entity1 foot wound for at least 3 months were included in this double-blind randomized clinical trial. @entity0 were randomized to receive placebo treatment (n = 10) or LLLT (n = 13) (685 nm, energy density 10 J/cm(2)) in addition to conventional therapy. @entity0 were followed for 20 weeks. Ulcer size reduction and the number of @entity0 with complete healing were compared between the LLLT and placebo groups. RESULTS: There were no significant differences in baseline characteristics of @entity0 and foot @entity2 receiving LLLT and placebo treatment. At week 4, the size of @entity2 decreased significantly in the LLLT group (p = 0.04). After 20 weeks, in the LLLT group, eight @entity0 had complete healing and in the placebo group only three @entity0 experienced complete wound healing. The mean time of complete healing in LLLT @entity0 (11 weeks) was less than that in placebo @entity0 (14 weeks) though the difference was not statistically significant. CONCLUSIONS: The study provides evidence that LLLT can accelerate the healing process of chronic @entity3 , and it can be presumed that LLLT may shorten the time period needed to achieve complete healing.

title: A randomized clinical trial on the effect of low-level laser therapy on chronic XXXX foot wound healing: a preliminary report.

answer: @entity1


abstract: @entity5 ( @entity5 ) is one of the most common and deadly causes of @entity1 worldwide. However, to date, the mechanisms underlying its pathogenesis remain unclear. The present study investigated the gene expression profile of @entity0 @entity3 cell line TE-1, a cell model for @entity5 , to gain insight to the genetic regulation of this disease. @entity0 @entity3 TE-1 cells and normal esophageal @entity0 cells were cultured for isolation of total RNA. Differential expression of RNA transcripts was assessed using the Agilent 4*44 K microarray, combined with real-time PCR (qRT-PCR) for validation. Classification and function of the differential genes were illustrated by bioinformatics processing including hierarchical clustering and gene ontology (GO) analysis. We identified 4,986 transcripts with differential expression (fold-change >= 1.5, P<0.05), including 2,368 up-regulated and 2,618 down-regulated transcripts. GO analysis showed that the dysregulated transcripts were associated with biological process, cellular component, and molecular function. After bioinformatic analysis of significantly regulated signaling pathways, we found these transcripts may target 35 gene pathways, including @entity4 signaling, @entity2 , ubiquitin-mediated proteolysis, insulin signaling, cell cycle, @entity7 metabolism, @entity6 signaling, and MAPK signaling. The differentially expressed transcripts were screened between the @entity3 cell line TE-1 and normal esophageal cell line HET-1A, as well as their target gene pathways. Further data mining is related to prevention and treatment of @entity3 .

title: Gene expression profile of @entity0 XXXX cell line TE-1.

answer: @entity5


abstract: @entity5 ( @entity5 ) is one of the most common and deadly causes of @entity1 worldwide. However, to date, the mechanisms underlying its pathogenesis remain unclear. The present study investigated the gene expression profile of @entity0 @entity3 cell line TE-1, a cell model for @entity5 , to gain insight to the genetic regulation of this disease. @entity0 @entity3 TE-1 cells and normal esophageal @entity0 cells were cultured for isolation of total RNA. Differential expression of RNA transcripts was assessed using the Agilent 4*44 K microarray, combined with real-time PCR (qRT-PCR) for validation. Classification and function of the differential genes were illustrated by bioinformatics processing including hierarchical clustering and gene ontology (GO) analysis. We identified 4,986 transcripts with differential expression (fold-change >= 1.5, P<0.05), including 2,368 up-regulated and 2,618 down-regulated transcripts. GO analysis showed that the dysregulated transcripts were associated with biological process, cellular component, and molecular function. After bioinformatic analysis of significantly regulated signaling pathways, we found these transcripts may target 35 gene pathways, including @entity4 signaling, @entity2 , ubiquitin-mediated proteolysis, insulin signaling, cell cycle, @entity7 metabolism, @entity6 signaling, and MAPK signaling. The differentially expressed transcripts were screened between the @entity3 cell line TE-1 and normal esophageal cell line HET-1A, as well as their target gene pathways. Further data mining is related to prevention and treatment of @entity3 .

title: Gene expression profile of XXXX @entity5 cell line TE-1.

answer: @entity0


abstract: PURPOSE: The purpose of this prospective study was to evaluate the efficiency, feasibility, and surgical outcomes of microlaparoscopy-assisted pull-through (MAPT) for @entity1 . METHODS: Starting in 2005, pull-through procedures for @entity1 were performed exclusively using 2-mm instruments and miniscopes (microlaparoscopy). Three miniports were inserted laterally in the right abdominal wall in one line, with the miniscope at the level of the umbilicus and the working trocars cranially/caudally of the scope. The left colon was dissected, and transanal pull-through was performed. RESULTS: MAPT was performed in 16 @entity0 (10 @entity0 and 6 @entity0 ; average age: 5.7 months). Six @entity0 had previous abdominal surgeries. A 1.9-mm cystoscope or a 2.4-mm arthroscope was used in the first 5 cases. In the remainder, a recently developed 2.4-mm miniscope was used for visualization. The length of the resected colon segment was up to the left colonic flexur in 5 @entity0 , up to the middle of the descending colon in 4 cases and up to the sigmoid-descending segment in 7 @entity0 . The average operation time was 185 minutes (range: 120-330 minutes). The only intraoperative complication that occurred was an injury of the right iliac vein by inadvertent slippage of an electrocautery hook requiring laparotomy. At follow-up, 80% of the parents were unable to identify the scars after microlaparoscopy. CONCLUSION: MAPT is a safe and practical procedure regardless of age or previous surgery.

title: A microlaparoscopically assisted pull-through procedure for XXXX : initial experiences.

answer: @entity1


abstract: The authors report here robust autophagy observed by electron microscopy in both the Echigo-1 strain of @entity2 in hamsters and the Fujisaki strain of Gerstmann-Str  ussler-Scheinker disease in @entity0 . In both models, autophagic vacuoles were observed in several cellular compartments. In neuronal cell bodies, autophagic vacuoles of different size were seen. The cytoplasm of some neurons also contained semicircular cisterns equivalent to an early autophasophore. The major target of autophagy was @entity3 , i.e., enlarged neuritic processes--mostly dendrites but also axonal terminals and preterminals. They contained numerous double- or multiple-membrane-bound autophagosomes or autophagolysosomes and large multivesicular bodies. Multivesicular bodies were also observed within autophagic vacuoles, and large multivesicular bodies were seen within synaptic terminals. Some @entity3 was filled almost completely with multivesicular bodies; the latter were occasionally confluent. The authors conclude that autophagy is an important part of @entity1 . They also suggest that spongiform vacuoles, a hallmark for the whole group of @entity1 , may in reality originate from autophagic vacuoles.

title: Autophagy contributes to widespread neuronal degeneration in hamsters infected with the Echigo-1 strain of XXXX and @entity0 infected with the Fujisaki strain of Gerstmann-Str  ussler-Scheinker (GSS) syndrome.

answer: @entity2


abstract: The authors report here robust autophagy observed by electron microscopy in both the Echigo-1 strain of @entity2 in hamsters and the Fujisaki strain of Gerstmann-Str  ussler-Scheinker disease in @entity0 . In both models, autophagic vacuoles were observed in several cellular compartments. In neuronal cell bodies, autophagic vacuoles of different size were seen. The cytoplasm of some neurons also contained semicircular cisterns equivalent to an early autophasophore. The major target of autophagy was @entity3 , i.e., enlarged neuritic processes--mostly dendrites but also axonal terminals and preterminals. They contained numerous double- or multiple-membrane-bound autophagosomes or autophagolysosomes and large multivesicular bodies. Multivesicular bodies were also observed within autophagic vacuoles, and large multivesicular bodies were seen within synaptic terminals. Some @entity3 was filled almost completely with multivesicular bodies; the latter were occasionally confluent. The authors conclude that autophagy is an important part of @entity1 . They also suggest that spongiform vacuoles, a hallmark for the whole group of @entity1 , may in reality originate from autophagic vacuoles.

title: Autophagy contributes to widespread neuronal degeneration in hamsters infected with the Echigo-1 strain of @entity2 and XXXX infected with the Fujisaki strain of Gerstmann-Str  ussler-Scheinker (GSS) syndrome.

answer: @entity0


abstract: AIM: The aim of this study was to compare endoloops and endostaples for closing the stump of the appendix during laparoscopic appendectomy (LA) for @entity2 in @entity0 . METHODS: All LA performed for @entity2 from 2005 to 2009 were analyzed prospectively. Cases of @entity1 such as @entity2 or @entity5 were excluded, leaving 75 cases closed with loops and 81 cases closed with staples. Choice of technique was determined by the attending surgeon's preference. All @entity0 were managed according to the same pre-, intra-, and postoperative protocols. RESULTS: There were no significant differences between mean age at surgery, gender ratio, preoperative mean white blood cell count and mean @entity3 , histopathologic findings, mean duration of surgery, and mean hospitalization. There were no intra-operative complications in either group, but one loop case required conversion to open surgery (P   =   NS). There were no significant differences in the incidences of @entity5 , transient @entity4 . The postoperative readmission rate for management of complications was 4.0% for loop cases and 2.5% for staple cases (P   =   NS). Overall, using staples for a standard LA (anesthesia and stump closure) was U.S.  405 more expensive than when loops were used. CONCLUSION: This is the first prospective study comparing endoloops with endostaples for closing the stump of the appendix during LA for @entity2 in @entity0 . Although stapling proved to be more expensive, the choice of technique should reflect the surgeon's experience and confidence to ensure that the @entity0 has the safest possible LA.

title: A prospective analysis of endoloops and endostaples for closing the stump of the appendix in XXXX .

answer: @entity0


abstract: BACKGROUND: Much controversy exists regarding the initial choice of antibiotics and selected outcomes for @entity0 with @entity1 ( @entity1 ). METHODS: The investigators analyzed a hospital claims-made database to assess the impact of initial antibiotic choice on 30-day mortality, total hospital costs, and hospital length of stay (LOS). Fine risk groups allowed for stratification for variations in the severity of illness. @entity0 were divided into five monotherapy groups (ie, @entity2 , "other" @entity3 , @entity4 , @entity5 , or penicillins) and four groups that received dual therapy (ie, the agents listed above, except @entity5 ) plus @entity5 . @entity0 also were stratified by age (ie, > 65 years of age and < 65 years of age). Severely ill @entity0 were excluded. RESULTS: Overall, 44,814 @entity0 met the criteria for inclusion. Among monotherapy @entity0 , those who received @entity5 had the least mortality but were the least ill. @entity0 who received dual therapy generally had shorter LOSs, lower total hospital charges, and decreased mortality compared with those who received monotherapy. Differences among dual-therapy regimens regarding outcomes studies were noted. @entity0 who were < 65 years of age had lower mortality rates, shorter LOSs, and lower hospital charges than did the more elderly @entity0 . Within this group, those who received dual therapy had better outcomes than those who received monotherapy. CONCLUSIONS: We confirmed the value of dual therapy employing @entity5 as a second agent in decreasing mortality from @entity1 , and we provided similar data regarding shorter LOSs and lower hospital charges. This appears to hold for a younger population. Differences among dual-therapy regimens (all employing @entity5 ) appear to exist and may be clinically relevant.

title: Impact of initial antibiotic choice on clinical outcomes in XXXX : analysis of a hospital claims-made database.

answer: @entity1


abstract: BACKGROUND: Diet has been identified as a major determinant of @entity2 ( @entity2 ) but little is known of its influence on @entity2 survival. AIMS: To study the influence of dietary factors on survival in @entity0 who had undergone potentially curative @entity2 surgery. @entity0 : Among 171 @entity0 included in a case control study of @entity2 aetiological factors, 10 year survival data on 148 @entity0 who underwent resection of the @entity1 for potential cure were obtained from a Registry of Digestive Tumours. METHODS: Tertiles of food and nutrient intakes were entered into Cox proportional hazards survival models, controlling for age, sex, @entity1 stage, and @entity1 location. RESULTS: Only five year survival was influenced by the pre-diagnosis diet. High energy intake, as a result of high @entity4 , protein, and lipid intake, was strongly related to increased survival. Five year relative risk of @entity3 for the highest versus the two lowest tertiles of energy intake was 0.18 (95% confidence interval 0.07; 0.44). This effect was similar in both sexes, for the colon and for the rectum. It was stronger in @entity0 with N+/M+ @entity1 (relative risk 0.06) than in those with less advanced @entity1 (relative risk 0.37; stage-energy interaction term non-significant). No specific food or nutrient could be identified as having prognostic significance. CONCLUSIONS: Whether high energy intake selects less severe tumoral clones or modifies antitumoral immunity remains unclear. Larger series need to be investigated before conducting intervention studies but our findings should prompt nutritional follow up in @entity2 @entity0 .

title: Influence of dietary factors on XXXX survival.

answer: @entity2


abstract: Eighty-two localized fibrous @entity1 of the pleura (LFTP) were reviewed retrospectively for the clinical, pathologic, and radiologic findings. Forty-four @entity0 and 38 @entity0 ranged in age from 17 to 78 years (mean, 54.7 years). Sixty-four benign LFTP ranged in size from 2 to 30 cm (mean, 13.2 cm), and 18 @entity1 ranged from 3 to 23 cm (mean, 14.4 cm). Forty-eight @entity0 (60%) presented with symptoms. Radiographs of 76 @entity0 demonstrated solitary masses occupying or extending into the inferior hemithorax (79%). Computed tomography (CT) of 78 lesions demonstrated lobular masses (83%) that formed at least one acute angle (96%) or only acute angles (65%) with the adjacent pleura. @entity2 attenuation was documented in 88% of enhanced and in 68% of unenhanced CT scans. Contrast enhancement was common (62% of cases). Magnetic resonance (MR) imaging of 18 lesions demonstrated heterogeneous signal intensity on both T1- and T2-weighted images (78% and 83%, respectively). Multiplanar MR imaging allowed visualization of the diaphragm and documentation of an intrathoracic mass in all cases. LFTP are solitary lobular heterogeneous masses that occur in symptomatic adults and often affect the inferior hemithorax. @entity1 are radiologically indistinguishable from those with benign histologic characteristics. Radiographic and CT features characteristic of pleural location are typically absent.

title: From the archives of the AFIP: Localized fibrous XXXX .

answer: @entity1


abstract: AIM: This article discusses the clinical implications of adverse health outcomes derived during heatwaves for @entity0 with @entity2 , substance misuse and those taking prescribed medications such as @entity4 , various neuroleptic and anticholinergic drugs. BACKGROUND: With climate change it is predicted that the incidence of prolonged periods of extreme heat will increase. Specific adverse health outcomes associated with high environmental temperatures include @entity1 and heat exhaustion. Those at increased risk for heat-related mortality are those with chronic health conditions, including those with @entity2 and substance misuse. DATA SOURCES: Sources of evidence included and 'grey' literature published between 1985 and 2010, such as key texts, empirical research, public policies, training manuals and community information sheets on heat waves. DISCUSSION: Current clinical practice and clinical impact of heatwaves on those @entity0 with comorbidity is explored. This includes the physiological components of heat stress, heat regulation, and the impact of @entity3 and other drugs; and, ramifications and professional practice issues for those with mental health conditions and those requiring mental health medications. IMPLICATIONS FOR NURSING: Client education covering modification of the environment and the use of client heat safety action plans. Secure, accessible stores of prescribed medication are recommended and emergency substance withdrawal kits could be made available. CONCLUSION: All nurses have a responsibility to increase the capability and resilience of their clients to manage their chronic health needs during a heatwave. At these times nurses need to give extra monitoring and assistance when clients lack the capacity or resources to protect themselves.

title: Heatwaves and their impact on @entity0 with XXXX , drug and mental health conditions: a discussion paper on clinical practice considerations.

answer: @entity3


abstract: AIM: This article discusses the clinical implications of adverse health outcomes derived during heatwaves for @entity0 with @entity2 , substance misuse and those taking prescribed medications such as @entity4 , various neuroleptic and anticholinergic drugs. BACKGROUND: With climate change it is predicted that the incidence of prolonged periods of extreme heat will increase. Specific adverse health outcomes associated with high environmental temperatures include @entity1 and heat exhaustion. Those at increased risk for heat-related mortality are those with chronic health conditions, including those with @entity2 and substance misuse. DATA SOURCES: Sources of evidence included and 'grey' literature published between 1985 and 2010, such as key texts, empirical research, public policies, training manuals and community information sheets on heat waves. DISCUSSION: Current clinical practice and clinical impact of heatwaves on those @entity0 with comorbidity is explored. This includes the physiological components of heat stress, heat regulation, and the impact of @entity3 and other drugs; and, ramifications and professional practice issues for those with mental health conditions and those requiring mental health medications. IMPLICATIONS FOR NURSING: Client education covering modification of the environment and the use of client heat safety action plans. Secure, accessible stores of prescribed medication are recommended and emergency substance withdrawal kits could be made available. CONCLUSION: All nurses have a responsibility to increase the capability and resilience of their clients to manage their chronic health needs during a heatwave. At these times nurses need to give extra monitoring and assistance when clients lack the capacity or resources to protect themselves.

title: Heatwaves and their impact on XXXX with @entity3 , drug and mental health conditions: a discussion paper on clinical practice considerations.

answer: @entity0


abstract: BACKGROUND: Previous studies on the effect of the @entity1 and @entity2 -containing varnish (Cervitec((R))) have consistently shown a reduction in @entity3 , while the data on the caries-inhibiting effect are conflicting. AIM: To measure the effect of a @entity1 - and @entity2 -containing varnish (Cervitec) on approximal caries in a low caries population. MATERIAL: Eighty-five schoolchildren, 13 years of age, entered the study after being selected on the basis of bitewing radiographs. @entity0 with at least one approximal lesion were included after informed consent. METHODS: The study was carried out as a double-blind, randomized controlled trial according to a split-mouth design using Cervitec on one side and a placebo varnish on the other side. All approximal surfaces between molars and premolars were treated every 3rd month. After 2 years new bitewing radiographs were taken. A total of 73 @entity0 completed the 2-year study. RESULTS: Neither the difference in number of new lesions between the Cervitec-treated and the placebo-treated side (d: -0.21; 95% CI: -0.57; 0.16) nor the mean difference in number of already existing lesions that progressed (d: -0.01; 95% CI: -0.33; 0.30) were statistically significant (paired t test; p > 0.05). CONCLUSION: The results of our study do not indicate an effect of Cervitec on initiation or progression of approximal caries in a population with a low DMFS.

title: Effect of a varnish containing XXXX and @entity2 (Cervitec) on approximal caries in 13- to 16-year-old schoolchildren in a low caries area.

answer: @entity1


abstract: BACKGROUND: Previous studies on the effect of the @entity1 and @entity2 -containing varnish (Cervitec((R))) have consistently shown a reduction in @entity3 , while the data on the caries-inhibiting effect are conflicting. AIM: To measure the effect of a @entity1 - and @entity2 -containing varnish (Cervitec) on approximal caries in a low caries population. MATERIAL: Eighty-five schoolchildren, 13 years of age, entered the study after being selected on the basis of bitewing radiographs. @entity0 with at least one approximal lesion were included after informed consent. METHODS: The study was carried out as a double-blind, randomized controlled trial according to a split-mouth design using Cervitec on one side and a placebo varnish on the other side. All approximal surfaces between molars and premolars were treated every 3rd month. After 2 years new bitewing radiographs were taken. A total of 73 @entity0 completed the 2-year study. RESULTS: Neither the difference in number of new lesions between the Cervitec-treated and the placebo-treated side (d: -0.21; 95% CI: -0.57; 0.16) nor the mean difference in number of already existing lesions that progressed (d: -0.01; 95% CI: -0.33; 0.30) were statistically significant (paired t test; p > 0.05). CONCLUSION: The results of our study do not indicate an effect of Cervitec on initiation or progression of approximal caries in a population with a low DMFS.

title: Effect of a varnish containing @entity1 and XXXX (Cervitec) on approximal caries in 13- to 16-year-old schoolchildren in a low caries area.

answer: @entity2


abstract: @entity1 factor management by French vs US primary care physicians was studied. A survey was conducted that found that French physicians spend >20 minutes while US physicians spend five to 10 minutes (P<.001) addressing cardiovascular risk with @entity0 . Fifty-three percent of French (vs 33% of US) physicians focus more on lifestyle modification and less on medication management (P<.0001). Sixty-nine percent of French physicians spend 0% to 20% of their time on administration while 65% of US physicians spend 10% to 30% (P=.0028). Fifty-one percent of French physicians see @entity0 in one to three months for follow-up, while 51% of US physicians see @entity0 in three to six months (P<.0001). Eighty-seven percent of French (vs 39% of US) physicians have guidelines available in the examination room either frequently or very frequently. US physicians report disparities in care more frequently than do French physicians (P<.0001). Forty-nine percent of French (vs 10% of US) physicians believe that they have relative freedom to practice medicine (P<.001). US physicians report greater administrative efforts, frustration, and disparities in their practice. French physicians focus more of their efforts on lifestyle management and see their @entity0 more frequently and for a longer visit time.

title: Physician XXXX risk factor management: practices in France vs the United States.

answer: @entity1


abstract: The ultrasonic diagnosis of @entity2 can give a more accurate information than clinical data alone. In diagnosis of the parotid gland diseases, it is necessary to differentiate @entity1 from other diseases. When a @entity1 is suspected, its presence should be confirmed, and determined if it is solitary, multiple, unilateral or bilateral, intra or extraglandular, and benign or malignant. In the period of May 1998 to January 2001 ultrasound examinations were performed in 354 @entity0 , FNAB with ultrasound control were performed in 152 @entity0 with a mean age of 49.7 years. The ultrasound and cytologic findings were correlated with surgical and histologic findings. Results indicate that in @entity0 with solid mass of the salivary gland, ultrasound examination confirmed the finding of @entity1 in all @entity0 (100%). In non-solid diseases of salivary glands the diagnostic accuracy was slightly lower. The use of ultrasound techniques in the study of salivary gland pathology is well justified, due to its capacity to provide high resolution and improving clinical diagnosis. FNAB is a simple quick, accurate and virtually complications free investigative modality. The data on its ability to distinguish between lesions requiring surgery or not are encouraging.

title: Fine needle aspiration biopsy in a diagnostic workup algorithm of XXXX .

answer: @entity1


abstract: OBJECTIVES: To determine the incremental risk of diagnosis of clinically insignificant @entity2 with serial prostate biopsies. METHODS: We reviewed our institutional radical prostatectomy (RP) database comprising 2411 consecutive @entity0 undergoing RP. We then stratified @entity0 by the prostate biopsy on which their @entity1 was diagnosed and correlated biopsy number with the risk of clinically insignificant disease and adverse pathology at radical prostatectomy. RESULTS: A total of 1867 (77.4%), 281 (11.9%), and 175 (7.3%) @entity0 underwent 1, 2, and 3 or more prostate biopsies, respectively, before RP. Increasing number of prostate biopsies was associated with increasing prostate volume (P <.01), @entity3 (P <.01), associated @entity4 (P <.01), and increased likelihood of clinical Gleason 6 or less disease (P <.01). On pathologic analysis, increasing number of prostate biopsies was associated with increased risk of low-volume (P <.01), organ-confined (P <.01) disease. The risk of clinically insignificant disease was found to be 31.1%, 43.8%, and 46.8% in those undergoing 1, 2, and 3+ prostate biopsies, respectively. Conversely, the risk of adverse pathology was found to be 64.6%, 53.0%, and 52.0% in those undergoing 1, 2, and 3+ prostate biopsies, respectively. CONCLUSIONS: @entity0 undergoing multiple prostate biopsies before RP are more likely to harbor clinically insignificant @entity2 than those who only undergo 1 biopsy before resection. Nonetheless, the risk of adverse pathology in @entity0 undergoing serial biopsies remains significant. The increased risk of @entity2 overdiagnosis and overtreatment must be balanced with the continued risk of clinically significant disease when counseling @entity0 regarding serial biopsies.

title: Repeat prostate biopsy and the incremental risk of clinically insignificant XXXX .

answer: @entity2


abstract: BACKGROUND: Primary @entity3 is an extremely rare @entity13 with fewer than 30 documented cases worldwide. Immunohistochemically, @entity3 are characterized by the expression of alpha-smooth muscle actin (alpha-SMA). Until recently, no report investigated the role of @entity8 expression in primary @entity3 . We report the management and an immunohistochemical analysis of @entity8 in a @entity0 with primary @entity3 . CASE REPORT: The @entity0 , a 71-year-old @entity0 , presented with a history of lower @entity6 and a palpable mass in the lower abdomen. Surgical exploration revealed a large left adnexal mass that had developed from the left ovary and infiltrated one part of the omentum adherent to the left adnexa. Microscopically the left @entity1 consisted of spindle cells arranged in smooth-muscle bundles and fascicles. The @entity1 was characterized by high cellularity and nuclear polymorphism, as well as patchy @entity2 and large areas of @entity7 . Mitotic activity exceeded 5 mitoses per 10 high-power fields with many atypical mitoses. The @entity1 appeared encapsulated, and the capsule was partially disrupted by @entity1 cells. Immunohistochemically, the @entity1 showed a strong staining reaction for muscle actin, alpha-SMA and @entity12 , and also a weak reaction for @entity11 . Strong staining of @entity8 was detected, with more than 80% of @entity5 cells positive. According to the FIGO staging system for @entity3 , the @entity1 was classified as a primary @entity3 stage III C, and the @entity0 was treated with an adjuvant chemotherapy regimen consisting of @entity9 and @entity10 . Two days after the third cycle of @entity9 /ifosfamid she developed an apoplexy spontaneously and chemotherapy was therefore discontinued. The @entity0 remained without evidence of disease until she died as a result of intercurrent @entity4 14 months after initial surgery. CONCLUSIONS: Beside the routine histological and immunohistochemical characteristics of primary @entity3 , strong staining for @entity8 was detected. In order to understand more about the nature and the behaviour of this highly malignant @entity1 and to be able to improve the treatment, the prognostic value of @entity8 has to be investigated in additional studies.

title: @entity8 expression in a primary XXXX : a case report.

answer: @entity3


abstract: BACKGROUND: Primary @entity3 is an extremely rare @entity13 with fewer than 30 documented cases worldwide. Immunohistochemically, @entity3 are characterized by the expression of alpha-smooth muscle actin (alpha-SMA). Until recently, no report investigated the role of @entity8 expression in primary @entity3 . We report the management and an immunohistochemical analysis of @entity8 in a @entity0 with primary @entity3 . CASE REPORT: The @entity0 , a 71-year-old @entity0 , presented with a history of lower @entity6 and a palpable mass in the lower abdomen. Surgical exploration revealed a large left adnexal mass that had developed from the left ovary and infiltrated one part of the omentum adherent to the left adnexa. Microscopically the left @entity1 consisted of spindle cells arranged in smooth-muscle bundles and fascicles. The @entity1 was characterized by high cellularity and nuclear polymorphism, as well as patchy @entity2 and large areas of @entity7 . Mitotic activity exceeded 5 mitoses per 10 high-power fields with many atypical mitoses. The @entity1 appeared encapsulated, and the capsule was partially disrupted by @entity1 cells. Immunohistochemically, the @entity1 showed a strong staining reaction for muscle actin, alpha-SMA and @entity12 , and also a weak reaction for @entity11 . Strong staining of @entity8 was detected, with more than 80% of @entity5 cells positive. According to the FIGO staging system for @entity3 , the @entity1 was classified as a primary @entity3 stage III C, and the @entity0 was treated with an adjuvant chemotherapy regimen consisting of @entity9 and @entity10 . Two days after the third cycle of @entity9 /ifosfamid she developed an apoplexy spontaneously and chemotherapy was therefore discontinued. The @entity0 remained without evidence of disease until she died as a result of intercurrent @entity4 14 months after initial surgery. CONCLUSIONS: Beside the routine histological and immunohistochemical characteristics of primary @entity3 , strong staining for @entity8 was detected. In order to understand more about the nature and the behaviour of this highly malignant @entity1 and to be able to improve the treatment, the prognostic value of @entity8 has to be investigated in additional studies.

title: XXXX expression in a primary @entity3 : a case report.

answer: @entity8


abstract: BACKGROUND AND AIMS: Nearly 25% of normal weight individuals display abnormal metabolic profiles associated with @entity1 . As a wide range in body fat percentage (%BF) exists for BMI-defined normal weight individuals, we investigated whether elevated %BF (determined using DXA) was associated with @entity8 among 977 normal weight subjects (192 @entity0 , 785 @entity0 ) from the Canadian province of Newfoundland and Labrador. METHODS AND RESULTS: BMI and %BF were measured after a 12-h fasting period. @entity7 considered included elevated @entity5 , @entity6 and hsCRP levels, decreased HDL @entity4 , insulin resistance, and @entity3 . Subjects were classified as metabolically healthy (0 or 1 @entity7 ) or abnormal (>= 2 @entity7 ) and divided into sex-specific %BF tertiles as follows: low ( <=15.2% @entity0 ,  <=29.7% @entity0 ), medium (15.3-20.7%% @entity0 , 29.8-34.9%% @entity0 ) and high (>= 20.8% @entity0 , >= 35.0% @entity0 ). The prevalence of the metabolically abnormal phenotype was higher among medium and high %BF subjects (12.0% and 19.5%, respectively) compared to the low group (7.4%; p  <  0.05). Furthermore, the odds of being metabolically abnormal were 1.61 (95% CI 0.94-2.77) for medium %BF subjects compared to the low group and nearly tripled for high %BF subjects (OR 2.73, 95% CI 1.63-4.86). ORs remained significant after further adjustment for waist circumference. CONCLUSION: Our findings indicate that those with elevated %BF are at increased risk of developing @entity2 despite having a normal BMI. Future development of adequate screening tools to identify these individuals is crucial to the prevention of @entity1 .

title: Body fat percentage is associated with XXXX in BMI-defined normal weight subjects.

answer: @entity8


abstract: OBJECTIVE: Low-frequency repetitive transcranial magnetic stimulation (rTMS) is emerging as a therapeutic tool in @entity1 . In recent years, several open-label trials have shown an encouraging reduction in @entity2 frequency in @entity0 with @entity1 . However, the data from controlled trials are mixed with respect to antiepileptic rTMS efficacy, and the field would benefit from further carefully controlled trials. Prior to initiating new trials, it is important assess the magnitude of the placebo effect of presently used sham rTMS methods. METHODS: We systematically analyzed individual subject data from three placebo-controlled trials and measured the placebo effect at follow-up intervals of 2, 4, and 8 weeks after sham rTMS treatment. Given the relatively small subgroup sample size, placebo condition data were pooled for analysis. RESULTS: Three methods for sham rTMS were employed in the reviewed studies: (1) coil positioning orthogonal to the scalp, (2) a spring-loaded sham coil, and (3) a double active-sham coil. The placebo response overall was consistently low across follow-up intervals, both for median change in @entity2 frequency (Kruskal-Wallis, P>0.4, df=2) and for responder (defined as >=  50% @entity2 frequency reduction) rate (Fisher's exact rest, P>0.9, df=2). The aggregate effect of the placebo condition was a 0-2% median @entity2 reduction rate and a responder rate of 16-20%. CONCLUSION: We anticipate that these data will contribute to future power analysis as well as selection and design of sham rTMS methods for controlled rTMS trials.

title: An estimate of placebo effect of repetitive transcranial magnetic stimulation in XXXX .

answer: @entity1


abstract: Autogenous fat augmentation for @entity2 has been used previously in @entity0 treatment regimes. However, relatively little information is currently available regarding the effectiveness of fat injection for @entity0 with vocal fold @entity1 who have complete glottal closure (VFACGC). This paper compares, in retrospect, the efficiency of fat injection after surgery in @entity0 with VFACGC (n=21). The perceptual acoustic and phonatory functions and videolaryngostroboscopic data were evaluated before and after fat augmentation was performed on 13 @entity0 . Mean follow-up time was 9.5 months. Fifteen @entity0 displayed excellent results, four experienced post-procedure failure, and two were unavailable for follow-up analysis. The majority of VFACGC @entity0 (71%) also suffered from muscular @entity3 (MTD) preoperatively. The procedure also resolved the MTD in half (54%) of the @entity0 in this study. Perceptual rating showed significant improvement in grade, roughness and breathiness (P<0.05). The videolaryngostroboscopic rating showed significant improvements in vocal fold edge linearity (P<0.01), vocal fold vibration amplitude and mucosal wave excursion (P<0.05). VFACGC is commonly misdiagnosed as MTD and is, therefore, unresponsive to speech therapy that is targeted to the latter. Fat injection is an effective autogenous implant and should be considered as an option in the treatment of @entity0 with VFACGC. Although fat re-absorption was identified as a problem, repeating the procedure could be considered to minimize the effect of such.

title: Autogenous fat injection for vocal fold XXXX .

answer: @entity1


abstract: UNASSIGNED: Wide surgical resection or a marginal/incomplete resection followed by full-course radiation therapy is the current standard of care for @entity3 soft tissue @entity4 . The purpose of this retrospective, descriptive, bi-institutional study was to determine the effectiveness and @entity2 of a hypofractionated 5  *  6 Gy protocol on macroscopic @entity3 soft tissue @entity4 in terms of progression-free interval (PFI) and @entity5 ( @entity5 ), and to identify prognostic factors for @entity0 outcome. @entity3 with @entity4 irradiated with 5 * 6 Gy were eligible for the study. @entity5 were compared with respect to different @entity1 and @entity0 characteristics by the Kaplan-Meier method and multivariable Cox regression analysis. Fifty @entity3 with macroscopic disease were included. All @entity3 received the same radiation therapy protocol; part of the group (n = 20) received postradiation metronomic chemotherapy. Median PFI for all cases was 419 days (95% confidence interval (CI): 287-551) and median @entity5 was 513 days (95% CI: 368-658). @entity3 with @entity1 on the limbs had significantly longer PFI and @entity5 , compared with head or trunk. Increasing @entity1 burden decreased @entity5 . The addition of metronomic chemotherapy yielded a significantly longer @entity5 (757 days (95% CI: 570-944) compared with @entity3 that did not receive systemic treatment (286 days (95% CI: 0-518), (P = 0.023)), but did not influence progression-free interval. @entity2 was low throughout all treatments. The 5 * 6 Gy radiation therapy protocol was well tolerated and provided long PFI and @entity5 in @entity3 with @entity4 .

title: HYPOFRACTIONATED RADIOTHERAPY FOR MACROSCOPIC XXXX SOFT TISSUE SARCOMA: A RETROSPECTIVE STUDY OF 50 CASES TREATED WITH A 5 * 6 GY PROTOCOL WITH OR WITHOUT METRONOMIC CHEMOTHERAPY.

answer: @entity3


abstract: UNASSIGNED: Oral sedation for pre-cooperative and anxious pediatric @entity0 is an important tool for the pediatric dentist. Few studies have examined the sedation regimen of @entity3 and @entity2 . OBJECTIVES: The primary goal of this study was to evaluate the overall safety and effectiveness of the @entity3 / @entity2 drug combination. Secondary goals included detecting potential factors that alter sedation effectiveness. STUDY DESIGN: Two hundred and forty eight electronic health records of pediatric @entity0 (131 females, 117 males) who received @entity3 / @entity2 sedations in a university setting were evaluated. Pediatric dental residents rated each case according to the Frankl behavioral scale and for effectiveness. Numerous factors were analyzed to evaluate their significance on overall effectiveness. Factors examined included age at time of treatment, gender, ASA status, Frankl score at various points during treatment, sextant of treatment, operator experience, dosage, use of @entity1 , and any complications encountered during treatment, both major and minor. RESULTS: Over 81% of sedations were considered effective or very effective. Statistically significant findings included age of @entity0 , pre-sedation behavior, and willingness to take the medication. Less than 5% of sedations were aborted due to behavior. Only one major complication was found, which was not related to the sedation. CONCLUSIONS: @entity3 combined with @entity2 is a safe and effective sedation regimen for uncooperative or pre-cooperative @entity0 during dental treatment.

title: A Retrospective Study of 248 Pediatric Oral Sedations Utilizing the Combination of XXXX and @entity2 for Dental Treatment.

answer: @entity3


abstract: UNASSIGNED: Oral sedation for pre-cooperative and anxious pediatric @entity0 is an important tool for the pediatric dentist. Few studies have examined the sedation regimen of @entity3 and @entity2 . OBJECTIVES: The primary goal of this study was to evaluate the overall safety and effectiveness of the @entity3 / @entity2 drug combination. Secondary goals included detecting potential factors that alter sedation effectiveness. STUDY DESIGN: Two hundred and forty eight electronic health records of pediatric @entity0 (131 females, 117 males) who received @entity3 / @entity2 sedations in a university setting were evaluated. Pediatric dental residents rated each case according to the Frankl behavioral scale and for effectiveness. Numerous factors were analyzed to evaluate their significance on overall effectiveness. Factors examined included age at time of treatment, gender, ASA status, Frankl score at various points during treatment, sextant of treatment, operator experience, dosage, use of @entity1 , and any complications encountered during treatment, both major and minor. RESULTS: Over 81% of sedations were considered effective or very effective. Statistically significant findings included age of @entity0 , pre-sedation behavior, and willingness to take the medication. Less than 5% of sedations were aborted due to behavior. Only one major complication was found, which was not related to the sedation. CONCLUSIONS: @entity3 combined with @entity2 is a safe and effective sedation regimen for uncooperative or pre-cooperative @entity0 during dental treatment.

title: A Retrospective Study of 248 Pediatric Oral Sedations Utilizing the Combination of @entity3 and XXXX for Dental Treatment.

answer: @entity2


abstract: The purpose of this study was to determine whether (1) there is a menstrual phase effect on blood pressure (BP) and @entity1 ( @entity1 ), and (2) the effects of physical effort, posture, or moods on BP and @entity1 is mediated by the menstrual phase. Twelve normotensive @entity0 , aged between 28 and 50, with normal menstrual cycles were studied. BP was measured at 30- to 60-min intervals during a 24-hr period using an ambulatory BP monitor on Days 1, 8, 15, and 22 of the menstrual cycle. @entity0 were asked to report their posture, physical effort, and mood ("annoyed," "tense," and "happy") on 5-point Likert-type scales each time the ambulatory BP monitor took measurements. Systolic BP (SBP) was lower on Day 8 of the cycle. @entity2 were lower on Days 1 and 8. Daytime SBP was affected by the time of the day and posture, but not by moods, whereas daytime DBP was affected by posture and levels of tenseness. The level of physical effort only affected @entity1 , not BP. The average daytime physical and emotional variables had little influence over the average daytime BP. In 12 normotensive @entity0 with a normal menstrual cycle, SBP was lower during the follicular phase and DBP and @entity1 were lower during the follicular phase and menstruation even after controlling the effects of other factors. Physical activity or moods had only momentary effects on BP or @entity1 . A cross-validation statistical method used is suggested to study how individuals are affected by various factors. With the use of this method, the inclusion of menstrual phase in the model improved the prediction of SBP for 5 out of the 12 @entity0 studied.

title: Effects of daily activities on ambulatory blood pressure during menstrual cycle in normotensive XXXX .

answer: @entity0


abstract: Disruption of the ureter is very rarely caused by a @entity1 , only 12 cases having been reported in Japan. A 20-year-old male suffered from a blunt @entity4 in a traffic accident. Although his urinalysis showed no abnormalities, a dull @entity2 in the left flank region persisted for over a week after the injury. Under the suspicion of @entity0 , an excretory urogram (DIP) was conducted. The form of renal pelvis and calyces was almost normal on both sides, while extravasation of contrast medium was recognized around the lower pole of the left kidney. The retrograde pyelogram of the left side revealed that catheterization was possible up to 30 cm from the ureteral orifice, but the injected medium leaked into the retroperitoneal space making it impossible to visualize the left renal pelvis and calyces. An operation was performed under the diagnosis of left @entity5 on the 19th day after @entity1 . The left ureter was completely disrupted 2 cm distally from the ureteropelvic junction. An end to end @entity3 of the ureter was done with 6-0 Dexon sutures. The DIP taken on the 25th day after the operation showed slight dilatation of the left pelvis and calyces. However, the renogram conducted 6 months after the operation demonstrated a normal pattern on both sides.

title: [A case of XXXX caused by a traffic accident].

answer: @entity5


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2 ( @entity3 ) has been used for treating acne. The ability of @entity3 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity4 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity3 25% peels with those of @entity4 30% in @entity0 with @entity5 . MATERIALS AND METHODS: Twenty @entity0 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity3 was applied to the right half of the face and 30% @entity4 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity4 peeling (95%) versus (85%) with @entity3 . Total comedones improvement was more frequent with @entity3 peeling (80%) versus (70%) with @entity4 . Improvement of inflammatory lesions was more frequent among the side treated with @entity4 (85%) versus (80%) with @entity3 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2 is more superior in treating @entity1 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: @entity2 Versus @entity4 in the Treatment of @entity5 in Dark-Skinned XXXX .

answer: @entity0


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2 ( @entity3 ) has been used for treating acne. The ability of @entity3 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity4 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity3 25% peels with those of @entity4 30% in @entity0 with @entity5 . MATERIALS AND METHODS: Twenty @entity0 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity3 was applied to the right half of the face and 30% @entity4 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity4 peeling (95%) versus (85%) with @entity3 . Total comedones improvement was more frequent with @entity3 peeling (80%) versus (70%) with @entity4 . Improvement of inflammatory lesions was more frequent among the side treated with @entity4 (85%) versus (80%) with @entity3 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2 is more superior in treating @entity1 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: @entity2 Versus XXXX in the Treatment of @entity5 in Dark-Skinned @entity0 .

answer: @entity4


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2 ( @entity3 ) has been used for treating acne. The ability of @entity3 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity4 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity3 25% peels with those of @entity4 30% in @entity0 with @entity5 . MATERIALS AND METHODS: Twenty @entity0 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity3 was applied to the right half of the face and 30% @entity4 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity4 peeling (95%) versus (85%) with @entity3 . Total comedones improvement was more frequent with @entity3 peeling (80%) versus (70%) with @entity4 . Improvement of inflammatory lesions was more frequent among the side treated with @entity4 (85%) versus (80%) with @entity3 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2 is more superior in treating @entity1 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: XXXX Versus @entity4 in the Treatment of @entity5 in Dark-Skinned @entity0 .

answer: @entity2


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2 ( @entity3 ) has been used for treating acne. The ability of @entity3 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity4 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity3 25% peels with those of @entity4 30% in @entity0 with @entity5 . MATERIALS AND METHODS: Twenty @entity0 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity3 was applied to the right half of the face and 30% @entity4 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity4 peeling (95%) versus (85%) with @entity3 . Total comedones improvement was more frequent with @entity3 peeling (80%) versus (70%) with @entity4 . Improvement of inflammatory lesions was more frequent among the side treated with @entity4 (85%) versus (80%) with @entity3 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2 is more superior in treating @entity1 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: @entity2 Versus @entity4 in the Treatment of XXXX in Dark-Skinned @entity0 .

answer: @entity5


abstract: BACKGROUND: Spontaneous @entity9 ( @entity9 ) is a devastating @entity2 subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of @entity7 and @entity8 to @entity9 ( @entity9 ) susceptibility and @entity6 size. METHODS: Associations were tested by logistic regression and @entity10 ( @entity10 ) where appropriate, adjusting with covariables of age, sex, @entity3 , @entity1 , smoking, and @entity4 consumption. Association analyses were performed first by stratification of genders and then by the age of 65 years old (y/o). Elder population was defined as subjects who were older than 65 y/o. RESULTS: There were 396 @entity9 @entity0 and 376 control subjects in this study. In the elder group, @entity13 @entity11 variant in @entity8 was associated with @entity9 in male and overall @entity0 (OR = 3.49, 95% CI 1.45 to 8.40, P = 0.005 and OR = 2.45, 95% CI 1.37 to 4.38, P = 0.003, respectively) in additive genetic model. In recessive genetic model, @entity12 TT genotype in @entity7 was correlated to @entity9 in male @entity0 and overall elder group (OR = 7.30, 95% CI 1.3 to 40, P = 0.02 and OR = 2.91, 95% CI 1.02 to 8.31, P = 0.046, respectively), and @entity14 AA genotype in @entity8 was associated with @entity9 in female @entity0 (OR = 0.29, 95% CI 0.1 to 0.84, P = 0.02). In younger male and overall younger @entity0 , @entity9 @entity0 who had @entity5 had significantly lower frequency of AA genotypes in @entity14 than those with @entity5 (OR = 0.36, 95% CI 0.17 to 0.75, P = 0.006 and OR = 0.43, 95% CI 0.22 to 0.84, P = 0.014, respectively). @entity5 size increased by 9.7 (95% CI 2.1 to 43, P = 0.004) cm3 per minor allele (A) of the @entity13 variant in the elder female @entity0 and increased by 4.3 (95% CI 1.4 to 12.9, P = 0.009) cm3 per minor allele (A) in all elder @entity0 . In younger @entity0 , the @entity5 size decreased by 3.3 (95% CI 1.2 to 9.5, P = 0.03) cm3 per minor allele of the s7503726 variant in the female @entity0 . CONCLUSIONS: This study showed a significant association between the variants of @entity7 and @entity8 promoters and @entity9 susceptibility with significant age and gender differences. @entity5 location and size might be affected by @entity8 promoter variants in the @entity9 @entity0 .

title: Polymorphisms in the Promoters of the XXXX and @entity8 Genes Are Associated with Spontaneous @entity9 in the Taiwan Population.

answer: @entity7


abstract: BACKGROUND: Spontaneous @entity9 ( @entity9 ) is a devastating @entity2 subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of @entity7 and @entity8 to @entity9 ( @entity9 ) susceptibility and @entity6 size. METHODS: Associations were tested by logistic regression and @entity10 ( @entity10 ) where appropriate, adjusting with covariables of age, sex, @entity3 , @entity1 , smoking, and @entity4 consumption. Association analyses were performed first by stratification of genders and then by the age of 65 years old (y/o). Elder population was defined as subjects who were older than 65 y/o. RESULTS: There were 396 @entity9 @entity0 and 376 control subjects in this study. In the elder group, @entity13 @entity11 variant in @entity8 was associated with @entity9 in male and overall @entity0 (OR = 3.49, 95% CI 1.45 to 8.40, P = 0.005 and OR = 2.45, 95% CI 1.37 to 4.38, P = 0.003, respectively) in additive genetic model. In recessive genetic model, @entity12 TT genotype in @entity7 was correlated to @entity9 in male @entity0 and overall elder group (OR = 7.30, 95% CI 1.3 to 40, P = 0.02 and OR = 2.91, 95% CI 1.02 to 8.31, P = 0.046, respectively), and @entity14 AA genotype in @entity8 was associated with @entity9 in female @entity0 (OR = 0.29, 95% CI 0.1 to 0.84, P = 0.02). In younger male and overall younger @entity0 , @entity9 @entity0 who had @entity5 had significantly lower frequency of AA genotypes in @entity14 than those with @entity5 (OR = 0.36, 95% CI 0.17 to 0.75, P = 0.006 and OR = 0.43, 95% CI 0.22 to 0.84, P = 0.014, respectively). @entity5 size increased by 9.7 (95% CI 2.1 to 43, P = 0.004) cm3 per minor allele (A) of the @entity13 variant in the elder female @entity0 and increased by 4.3 (95% CI 1.4 to 12.9, P = 0.009) cm3 per minor allele (A) in all elder @entity0 . In younger @entity0 , the @entity5 size decreased by 3.3 (95% CI 1.2 to 9.5, P = 0.03) cm3 per minor allele of the s7503726 variant in the female @entity0 . CONCLUSIONS: This study showed a significant association between the variants of @entity7 and @entity8 promoters and @entity9 susceptibility with significant age and gender differences. @entity5 location and size might be affected by @entity8 promoter variants in the @entity9 @entity0 .

title: Polymorphisms in the Promoters of the @entity7 and XXXX Genes Are Associated with Spontaneous @entity9 in the Taiwan Population.

answer: @entity8


abstract: BACKGROUND: Spontaneous @entity9 ( @entity9 ) is a devastating @entity2 subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of @entity7 and @entity8 to @entity9 ( @entity9 ) susceptibility and @entity6 size. METHODS: Associations were tested by logistic regression and @entity10 ( @entity10 ) where appropriate, adjusting with covariables of age, sex, @entity3 , @entity1 , smoking, and @entity4 consumption. Association analyses were performed first by stratification of genders and then by the age of 65 years old (y/o). Elder population was defined as subjects who were older than 65 y/o. RESULTS: There were 396 @entity9 @entity0 and 376 control subjects in this study. In the elder group, @entity13 @entity11 variant in @entity8 was associated with @entity9 in male and overall @entity0 (OR = 3.49, 95% CI 1.45 to 8.40, P = 0.005 and OR = 2.45, 95% CI 1.37 to 4.38, P = 0.003, respectively) in additive genetic model. In recessive genetic model, @entity12 TT genotype in @entity7 was correlated to @entity9 in male @entity0 and overall elder group (OR = 7.30, 95% CI 1.3 to 40, P = 0.02 and OR = 2.91, 95% CI 1.02 to 8.31, P = 0.046, respectively), and @entity14 AA genotype in @entity8 was associated with @entity9 in female @entity0 (OR = 0.29, 95% CI 0.1 to 0.84, P = 0.02). In younger male and overall younger @entity0 , @entity9 @entity0 who had @entity5 had significantly lower frequency of AA genotypes in @entity14 than those with @entity5 (OR = 0.36, 95% CI 0.17 to 0.75, P = 0.006 and OR = 0.43, 95% CI 0.22 to 0.84, P = 0.014, respectively). @entity5 size increased by 9.7 (95% CI 2.1 to 43, P = 0.004) cm3 per minor allele (A) of the @entity13 variant in the elder female @entity0 and increased by 4.3 (95% CI 1.4 to 12.9, P = 0.009) cm3 per minor allele (A) in all elder @entity0 . In younger @entity0 , the @entity5 size decreased by 3.3 (95% CI 1.2 to 9.5, P = 0.03) cm3 per minor allele of the s7503726 variant in the female @entity0 . CONCLUSIONS: This study showed a significant association between the variants of @entity7 and @entity8 promoters and @entity9 susceptibility with significant age and gender differences. @entity5 location and size might be affected by @entity8 promoter variants in the @entity9 @entity0 .

title: Polymorphisms in the Promoters of the @entity7 and @entity8 Genes Are Associated with Spontaneous XXXX in the Taiwan Population.

answer: @entity9


abstract: UNASSIGNED: Background: There are not many studies investigating mental health of individuals with @entity3 . The aim of this study is to provide data on @entity2 and @entity1 in individuals with @entity3 . Method: In a cross-sectional study, we assessed @entity0 and @entity0 with @entity3 (18-65 years) with a standardized instrument with 2 divisions (division 1: variables "residence", "self-determination capabilities", "violence experiences", division 2: variables " @entity2 " and " @entity1 " with the @entity0 Health Questionaire-4). Univariate and bivariate analysis of the data was performed. Result: Out of a total of 59% @entity0 and 41% @entity0 , 44 participated in the study (response rate=45%). Overall, 20% (n=9) of the @entity0 had an increased PHQ-2 score. This can be used as an indicator for @entity2 . 18% (n=8) of the subject group indicated an increased @entity4 score. This can be used as an indicator of @entity1 . Risk factors for @entity2 were "an increased level of disability" (RR=11,8), "living with parents" (RR=6, 7), "limited self-determination capabilities"(RR=6,2) and "fear of new situations" (RR=5:0). Violence experiences were a risk factor (RR=13,3) for @entity1 . Conclusion: In view of the special methodological challenges of this study, the target group is very small. Nevertheless, this is one of the first studies in Germany that reveals factors with an impact on the mental health of individuals with @entity3 . The association of experience of violence with @entity1 in individuals with @entity3 represents an important challenge for public health.

title: ["Mental Health in Adults with @entity3 . Protective and Risk Factors for XXXX and @entity1 " - a Cross-sectional Study].

answer: @entity2


abstract: UNASSIGNED: Background: There are not many studies investigating mental health of individuals with @entity3 . The aim of this study is to provide data on @entity2 and @entity1 in individuals with @entity3 . Method: In a cross-sectional study, we assessed @entity0 and @entity0 with @entity3 (18-65 years) with a standardized instrument with 2 divisions (division 1: variables "residence", "self-determination capabilities", "violence experiences", division 2: variables " @entity2 " and " @entity1 " with the @entity0 Health Questionaire-4). Univariate and bivariate analysis of the data was performed. Result: Out of a total of 59% @entity0 and 41% @entity0 , 44 participated in the study (response rate=45%). Overall, 20% (n=9) of the @entity0 had an increased PHQ-2 score. This can be used as an indicator for @entity2 . 18% (n=8) of the subject group indicated an increased @entity4 score. This can be used as an indicator of @entity1 . Risk factors for @entity2 were "an increased level of disability" (RR=11,8), "living with parents" (RR=6, 7), "limited self-determination capabilities"(RR=6,2) and "fear of new situations" (RR=5:0). Violence experiences were a risk factor (RR=13,3) for @entity1 . Conclusion: In view of the special methodological challenges of this study, the target group is very small. Nevertheless, this is one of the first studies in Germany that reveals factors with an impact on the mental health of individuals with @entity3 . The association of experience of violence with @entity1 in individuals with @entity3 represents an important challenge for public health.

title: ["Mental Health in Adults with XXXX . Protective and Risk Factors for @entity2 and @entity1 " - a Cross-sectional Study].

answer: @entity3


abstract: UNASSIGNED: Background: There are not many studies investigating mental health of individuals with @entity3 . The aim of this study is to provide data on @entity2 and @entity1 in individuals with @entity3 . Method: In a cross-sectional study, we assessed @entity0 and @entity0 with @entity3 (18-65 years) with a standardized instrument with 2 divisions (division 1: variables "residence", "self-determination capabilities", "violence experiences", division 2: variables " @entity2 " and " @entity1 " with the @entity0 Health Questionaire-4). Univariate and bivariate analysis of the data was performed. Result: Out of a total of 59% @entity0 and 41% @entity0 , 44 participated in the study (response rate=45%). Overall, 20% (n=9) of the @entity0 had an increased PHQ-2 score. This can be used as an indicator for @entity2 . 18% (n=8) of the subject group indicated an increased @entity4 score. This can be used as an indicator of @entity1 . Risk factors for @entity2 were "an increased level of disability" (RR=11,8), "living with parents" (RR=6, 7), "limited self-determination capabilities"(RR=6,2) and "fear of new situations" (RR=5:0). Violence experiences were a risk factor (RR=13,3) for @entity1 . Conclusion: In view of the special methodological challenges of this study, the target group is very small. Nevertheless, this is one of the first studies in Germany that reveals factors with an impact on the mental health of individuals with @entity3 . The association of experience of violence with @entity1 in individuals with @entity3 represents an important challenge for public health.

title: ["Mental Health in Adults with @entity3 . Protective and Risk Factors for @entity2 and XXXX " - a Cross-sectional Study].

answer: @entity1


abstract: BACKGROUND: Early observational studies of endoscopic treatment and extracorporeal shock wave lithotripsy (ESWL) reported considerable or complete relief of @entity1 in 50%-80% of @entity0 with chronic @entity2 . There is no consensus on the measurement of @entity1 , making comparison of observational studies difficult, and little attention has been paid to the type and amount of analgesics used by @entity0 before and after decompressive treatment. METHODS: We performed a retrospective study of all @entity0 with chronic @entity2 and @entity3 and receiving decompressing treatment between 1 November 1994 and 31 July 1999. Primary parameters were type and amount of analgesics used. RESULTS: Forty-nine @entity0 with chronic @entity2 and @entity3 received stenting of the pancreatic duct (28 @entity0 ), ESWL (6 @entity0 ) or both (15 @entity0 ). After a median follow-up of 21 months, 35% of all @entity0 were @entity1 -free and a further 6% were not using analgesics. Seven @entity0 no longer needed opioids during follow-up, but five other @entity0 needed addition of opioids to treatment. The median opioid dose among opioid-dependent @entity0 rose slightly (9%). The median increase of weight after treatment was 1 kg per year. CONCLUSION: After decompressive treatment of @entity0 with chronic @entity2 and @entity3 , we observed a small increase in weight and a small reduction in the number of opioid users. The changes may not be different from the natural course of the disease.

title: Stenting and extracorporeal shock wave lithotripsy in chronic XXXX .

answer: @entity2


abstract: PURPOSE: The use of organs from deceased after @entity5 and extended criteria donors grew in the last decade. These organs are more sensitive to @entity2 -reperfusion injury during transplantation and current preservation protocols do not protect them adequately. MATERIALS AND METHODS: In an autotransplanted, deceased after @entity5 donor @entity6 kidney model we evaluated the benefits of supplementation with University of Wisconsin solution trophic factors and @entity7 , an inhibitor of p38 mitogen-activated protein kinase. RESULTS: Supplemented solution improved renal recovery and limited @entity2 -reperfusion injury, particularly when agents were used in conjunction. Long-term benefits were highlighted by @entity4 , as determined by Picrosirius staining, and @entity0 , as evaluated by renal cell infiltration. Mechanistic evaluation showed decreased expression of epithelial-to-mesenchymal transition markers, a process involved in renal @entity3 development. Tumor @entity1 factor-a was markedly decreased in the treated experimental group. Apoptosis was also decreased, accompanied by decreased p38 mitogen-activated protein kinase phosphorylation. CONCLUSIONS: Supplementing the current gold standard kidney preservation protocol with trophic factors and p38 mitogen-activated protein kinase inhibitors markedly increased the quality of grafts in our @entity6 deceased after @entity5 donor model. Hence, this represents a strategy of interest to improve transplantation outcomes.

title: Trophic factor and XXXX supplementation during cold storage rescue chronic renal injury.

answer: @entity7


abstract: PURPOSE: Abnormal miRNA expression has emerged as crucial factors in @entity2 and is important in the comprehension of @entity3 behavior. We determined the correlation of miRNA expression profiles with @entity3 progression. MATERIALS AND METHODS: We studied frozen specimens from 49 @entity0 treated for @entity3 with radical prostatectomy. We intentionally chose 28 @entity0 without and 21 with biochemical recurrence, defined as @entity5 greater than 0.2 ng/ml. The expression of 14 miRNAs was determined by quantitative reverse transcriptase-polymerase chain reaction. All radical prostatectomy specimens were studied in toto to determine @entity1 volume, Gleason score and 2002 TNM pathological stage. Benign prostate tissue from @entity4 served as a control. RESULTS: Four miRNAs were related to @entity1 recurrence. Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of @entity9 , @entity6 , @entity8 and @entity7 , respectively. When considering statistically significant clinical variables on univariate analysis of biochemical-free survival, @entity5 and @entity1 volume, results revealed that @entity9 and @entity1 volume were independently related to @entity1 recurrence. CONCLUSIONS: A high level of @entity9 is related to biochemical recurrence of @entity3 in @entity0 treated with radical prostatectomy. The role of @entity9 during @entity2 must be resolved in future studies to better understand the molecular pathways in which @entity9 is involved. This may open the possibility of using it as a prognostic marker and inspire the development of a target drug.

title: MicroRNA-100 expression is independently related to biochemical recurrence of XXXX .

answer: @entity3


abstract: Psychiatric language in Latvia has been invaded by the diagnosis of @entity2 and @entity2 . @entity2 has been promoted by the translation into Latvian of the International Classification of Diseases and by conferences organized by pharmaceutical companies and aimed at educating psychiatrists and family doctors about the new diagnostic categories. The language of @entity2 represents a radical departure from older languages of somatic distress that were central both to Soviet Psychiatry and to lay conceptualizations of distress. However, the new practitioners who favour the diagnosis of @entity2 have a highly atomistic and culture blind approach to @entity0 ' problems. In order to selectively cleanse the presentation of distress, various strategies for eliminating social context and suppressing @entity0 ' narratives are used during @entity1 consultations. Alongside these imported @entity1 languages, recognition of the physically and socially embedded nature of @entity0 experience and its historicity persist. Not all psychiatrists eliminate subjective narrative from the consultation dialogue. However, prioritizing mental over physical states is not linked in a straightforward way to other dualisms such as the intentional versus the accidental and the voluntary versus the involuntary. For many @entity2 @entity0 autonomy is restricted to being a good @entity0 and learning about their condition. Conversely, psychiatrists who start out by addressing their @entity0 ' physical discomfort may move on to open up a range of narrative possibilities.

title: From damaged nerves to XXXX : inevitability and hope in Latvian @entity1 narratives.

answer: @entity2


abstract: Psychiatric language in Latvia has been invaded by the diagnosis of @entity2 and @entity2 . @entity2 has been promoted by the translation into Latvian of the International Classification of Diseases and by conferences organized by pharmaceutical companies and aimed at educating psychiatrists and family doctors about the new diagnostic categories. The language of @entity2 represents a radical departure from older languages of somatic distress that were central both to Soviet Psychiatry and to lay conceptualizations of distress. However, the new practitioners who favour the diagnosis of @entity2 have a highly atomistic and culture blind approach to @entity0 ' problems. In order to selectively cleanse the presentation of distress, various strategies for eliminating social context and suppressing @entity0 ' narratives are used during @entity1 consultations. Alongside these imported @entity1 languages, recognition of the physically and socially embedded nature of @entity0 experience and its historicity persist. Not all psychiatrists eliminate subjective narrative from the consultation dialogue. However, prioritizing mental over physical states is not linked in a straightforward way to other dualisms such as the intentional versus the accidental and the voluntary versus the involuntary. For many @entity2 @entity0 autonomy is restricted to being a good @entity0 and learning about their condition. Conversely, psychiatrists who start out by addressing their @entity0 ' physical discomfort may move on to open up a range of narrative possibilities.

title: From damaged nerves to @entity2 : inevitability and hope in Latvian XXXX narratives.

answer: @entity1