abstract: OBJECTIVE: @entity3 ( @entity3 ) is often seen in conjunction with an underlying @entity4 . Imaging methods that are used to localize the @entity5 also detect associated thyroid nodules and @entity2 . The aim of this study was to detect the rate of @entity2 identified while performing parathyroidectomy and thyroidectomy in @entity0 with @entity3 . MATERIAL AND METHODS: Files of all @entity0 who were operated for @entity3 and who underwent simultaneous thyroidectomy were analyzed. Data regarding parathyroid pathology, surgical procedures, indications of thyroid surgery, and pathology results were retrospectively recorded. The indications for thyroid surgery included presence of suspicious thyroid nodules in ultrasonography, increase in size of thyroid nodules in follow-up ultrasound, or presence of suspicious thyroid fine needle aspiration biopsy (FNAB) findings. Rates of @entity2 detection were investigated according to definite pathology reports. RESULTS: Eighty-three @entity0 who underwent parathyroidectomy with a diagnosis of @entity3 with concurrent thyroidectomy in Department of General Surgery,   stanbul University   stanbul Faculty of Medicine were included in the study. Eighteen @entity0 were male (22%) and 65 were female (78%). The median age was 53 (18-70) years. The primary indication for parathyroidectomy was @entity3 in all @entity0 . The thyroid procedures applied in addition to parathyroidectomy were lobectomy + isthmusectomy in 29 @entity0 (35%), bilateral subtotal thyroidectomy in 20 @entity0 (24%), bilateral total thyroidectomy in 23 @entity0 (28%), and total thyroidectomy on one side and near total thyroidectomy to the other side in 11 @entity0 (13%). The only indication for thyroidectomy was the presence of thyroid nodules until 2000 (20 @entity0 , 24%). Indications in the remaining 63 @entity0 included the presence of multiple nodules that cannot be followed up by ultrasonography in 25 @entity0 (30%), presence of a suspicious nodule on ultrasonography in 33 @entity0 (40%), growth in nodule size in 2 @entity0 (2%), and detection of suspicious findings on FNAB in 3 @entity0 (4%). Five @entity0 (6%) were diagnosed with @entity6 , four of whom were @entity1 . CONCLUSION: Imaging methods performed to localize the pathological parathyroid gland for a diagnosis of @entity3 are useful in estimating other accompanying pathologies. Presence of thyroid nodules should be evaluated before all parathyroid procedures, and if the nodule has an indication for surgery, thyroid surgery should be considered at the same operation with parathyroid surgery.

title: XXXX incidence in simultaneous thyroidectomy with parathyroid surgery.

answer: @entity2


abstract: UNASSIGNED: @entity2 ( @entity2 ) is the most @entity1 due to its high recurrence rate following initial treatment. Previous studies have indicated that @entity1 stem cells (CSCs) may be a potential cause underlying the high proportion of recurrence. Side population (SP) cells isolated from @entity1 cell lines have been shown to exhibit characteristics associated with CSCs, but studies on SP cells in @entity0 ovarian SK-OV-3 cell line are limited. In the present study, the SP cell fraction (4.83% of the total cell population) was isolated using flow cytometry, and analyzed by immunocytochemical analysis and reverse transcription-quantitative polymerase chain reaction. The results showed that SP cells exhibited a high mean fluorescence intensity for @entity5 , a CSC marker, in addition to elevated expression of the CSCs-associated genes, @entity3 -binding cassette sub-family G member 2 and Nestin. These findings indicated the stem cell-like features of the SP cells. Furthermore, a colony formation test showed that the isolated SP cells possessed a marked capacity for self-regeneration and proliferation. In addition, a cell cycle assay involving @entity4 indicated that the SP cells were strongly resistant to chemotherapy. In conclusion, the present results suggested that SP cells isolated from the SK-OV-3 cell line exhibited properties typically associated with CSCs. Therefore, the isolated SP cells may be used to provide novel insight into potential therapies against @entity2 .

title: Isolation and characterization of side population cells from the @entity0 XXXX cell line SK-OV-3.

answer: @entity2


abstract: UNASSIGNED: @entity2 ( @entity2 ) is the most @entity1 due to its high recurrence rate following initial treatment. Previous studies have indicated that @entity1 stem cells (CSCs) may be a potential cause underlying the high proportion of recurrence. Side population (SP) cells isolated from @entity1 cell lines have been shown to exhibit characteristics associated with CSCs, but studies on SP cells in @entity0 ovarian SK-OV-3 cell line are limited. In the present study, the SP cell fraction (4.83% of the total cell population) was isolated using flow cytometry, and analyzed by immunocytochemical analysis and reverse transcription-quantitative polymerase chain reaction. The results showed that SP cells exhibited a high mean fluorescence intensity for @entity5 , a CSC marker, in addition to elevated expression of the CSCs-associated genes, @entity3 -binding cassette sub-family G member 2 and Nestin. These findings indicated the stem cell-like features of the SP cells. Furthermore, a colony formation test showed that the isolated SP cells possessed a marked capacity for self-regeneration and proliferation. In addition, a cell cycle assay involving @entity4 indicated that the SP cells were strongly resistant to chemotherapy. In conclusion, the present results suggested that SP cells isolated from the SK-OV-3 cell line exhibited properties typically associated with CSCs. Therefore, the isolated SP cells may be used to provide novel insight into potential therapies against @entity2 .

title: Isolation and characterization of side population cells from the XXXX @entity2 cell line SK-OV-3.

answer: @entity0


abstract: One-hundred thirty eligible @entity0 with advanced @entity1 who had received no prior chemotherapy were randomized to either @entity6 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity3 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity4 ( @entity4 ), 400 mg/m2 intravenously weekly--( @entity5 )--or @entity4 , 600 mg/m2 intravenously weekly ( @entity4 ). One hundred twenty-six @entity0 are evaluable for response. Of 62 @entity0 treated with @entity5 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity0 treated with @entity4 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity0 receiving @entity5 was 9.5 months compared with 10.3 months for @entity0 receiving @entity4 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity0 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity5 compared to @entity4 therapy alone in advanced @entity1 . In addition, hematologic @entity2 was significantly greater with the combination ( @entity5 ) regimen.

title: Combination chemotherapy ( @entity4 , methyl-CCNU, XXXX ) versus @entity4 alone for advanced previously untreated @entity1 . A phase III study of the Piedmont Oncology Association.

answer: @entity3


abstract: One-hundred thirty eligible @entity0 with advanced @entity1 who had received no prior chemotherapy were randomized to either @entity6 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity3 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity4 ( @entity4 ), 400 mg/m2 intravenously weekly--( @entity5 )--or @entity4 , 600 mg/m2 intravenously weekly ( @entity4 ). One hundred twenty-six @entity0 are evaluable for response. Of 62 @entity0 treated with @entity5 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity0 treated with @entity4 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity0 receiving @entity5 was 9.5 months compared with 10.3 months for @entity0 receiving @entity4 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity0 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity5 compared to @entity4 therapy alone in advanced @entity1 . In addition, hematologic @entity2 was significantly greater with the combination ( @entity5 ) regimen.

title: Combination chemotherapy ( @entity4 , methyl-CCNU, @entity3 ) versus @entity4 alone for advanced previously untreated XXXX . A phase III study of the Piedmont Oncology Association.

answer: @entity1


abstract: One-hundred thirty eligible @entity0 with advanced @entity1 who had received no prior chemotherapy were randomized to either @entity6 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity3 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity4 ( @entity4 ), 400 mg/m2 intravenously weekly--( @entity5 )--or @entity4 , 600 mg/m2 intravenously weekly ( @entity4 ). One hundred twenty-six @entity0 are evaluable for response. Of 62 @entity0 treated with @entity5 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity0 treated with @entity4 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity0 receiving @entity5 was 9.5 months compared with 10.3 months for @entity0 receiving @entity4 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity0 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity5 compared to @entity4 therapy alone in advanced @entity1 . In addition, hematologic @entity2 was significantly greater with the combination ( @entity5 ) regimen.

title: Combination chemotherapy ( XXXX , methyl-CCNU, @entity3 ) versus @entity4 alone for advanced previously untreated @entity1 . A phase III study of the Piedmont Oncology Association.

answer: @entity4


abstract: One-hundred thirty eligible @entity0 with advanced @entity1 who had received no prior chemotherapy were randomized to either @entity6 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity3 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity4 ( @entity4 ), 400 mg/m2 intravenously weekly--( @entity5 )--or @entity4 , 600 mg/m2 intravenously weekly ( @entity4 ). One hundred twenty-six @entity0 are evaluable for response. Of 62 @entity0 treated with @entity5 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity0 treated with @entity4 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity0 receiving @entity5 was 9.5 months compared with 10.3 months for @entity0 receiving @entity4 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity0 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity5 compared to @entity4 therapy alone in advanced @entity1 . In addition, hematologic @entity2 was significantly greater with the combination ( @entity5 ) regimen.

title: Combination chemotherapy ( @entity4 , methyl-CCNU, @entity3 ) versus XXXX alone for advanced previously untreated @entity1 . A phase III study of the Piedmont Oncology Association.

answer: @entity4


abstract: UNASSIGNED: The aim of the present study was to determine the long-term outcomes of @entity1 following a rotational atherectomy (ROTA). In this retrospective study, @entity0 that had undergone a ROTA of the bifurcation coronary lesions in Juntendo University Hospital (Tokyo, Japan) were enrolled between January 2007 and December 2009, and received follow-up for a median duration of 48 months (range, 12-84 months). A total of 337 @entity0 were enrolled. Each @entity0 was treated with an average of 1.2  0.4 ROTA burrs (mean size, 2.9  0.3 mm). Baseline lesion length, reference diameter, @entity5 ( @entity5 ) and percentage of diameter stenosis (%DS) prior to the procedure were comparable between the @entity4 and non- @entity4 @entity0 . Furthermore, @entity5 , %DS and @entity3 following the procedure were similar between the two groups. At follow-up, @entity4 @entity0 exhibited a significantly decreased @entity5 (1.97  0.92 vs. 2.26  0.73 mm; P=0.0038), increased %DS (27.9  21.3 vs. 20.2  13.3%; P=0.022) and late loss (0.70  0.45 vs. 0.42  0.36 mm; P=0.0047) compared with the non- @entity4 @entity0 . Follow-up examinations (mean duration, 52.2  19.4 months) revealed that the @entity4 @entity0 experienced significantly higher rates of @entity1 revascularization (TLR) [28 (15.7%) vs. 8 (5.0%); P=0.0011], @entity1 ( @entity1 ) restenosis [46 (25.8%) vs. 20 (12.6%); P=0.0019] and major adverse @entity2 (MACE) [36 (20.2%) vs. 19 (12.0%), P=0.039] compared with the non- @entity4 @entity0 . Although the usage of ROTA and drug-eluting stent evidently improved long-term outcomes in @entity0 with @entity1 , @entity4 remained an independent risk factor for TLR, @entity1 restenosis and MACE. Therefore, the management of @entity4 in @entity1 treated with ROTA requires increased investigation in future clinical practice.

title: Long-term outcomes of rotational atherectomy in coronary XXXX .

answer: @entity1


abstract: BACKGROUND: The non-operative management of blunt @entity3 can be applied in almost 80% of @entity0 with this @entity2 , with the advantages of the need for fewer blood transfusions, less @entity4 , and a better survival rate, than with the operative approach. However, @entity5 , as a known complication of the non-operative management of blunt @entity3 , is discussed infrequently. Therefore, we herein review our experience and describe this complication in detail. MATERIALS AND METHODS: From 1995 to 2001, 674 @entity0 were admitted to our hospital due to blunt @entity1 . Among these @entity0 , 279 underwent laparotomy and the remaining 395 @entity0 were treated non-operatively. Twenty-two @entity0 were identified as having @entity5 , with 16 of them belonging to the operative group, and six to the non-operative group. A retrospective review of these six @entity0 and their characteristics, as well as pathogenesis, diagnosis, and the management of the liver abscesses, was conducted. RESULTS: These six @entity0 were all male, with a median age of 19.5 years (range 3-24). The median injury severity score was 16.5 (range 9-25); three @entity0 sustained grade-3 @entity1 , and the other three were grade 4. The main diagnostic tool was abdominal computed tomography, and the abscesses took a median of 6 days (range 1-12) to form and be diagnosed. The abscesses were usually caused by infection from mixed organisms, and an abscess resulting from @entity6 developed within 1 day after injury. These abscesses were treated with antibiotics and drainage, and the median length of hospital stay was 26 days (range 8-44), without mortality or long-term morbidity. CONCLUSION: @entity5 as a complication of the non-operative management of blunt @entity1 is a rare entity, with an incidence of 1.5% (6/395). It is usually seen in severe @entity1 (grade 3 and above), but all our @entity0 were all treated successfully, with no mortality. However, prolonged hospitalization may be required in this @entity0 group.

title: @entity5 after non-operative management of blunt XXXX .

answer: @entity1


abstract: BACKGROUND: The non-operative management of blunt @entity3 can be applied in almost 80% of @entity0 with this @entity2 , with the advantages of the need for fewer blood transfusions, less @entity4 , and a better survival rate, than with the operative approach. However, @entity5 , as a known complication of the non-operative management of blunt @entity3 , is discussed infrequently. Therefore, we herein review our experience and describe this complication in detail. MATERIALS AND METHODS: From 1995 to 2001, 674 @entity0 were admitted to our hospital due to blunt @entity1 . Among these @entity0 , 279 underwent laparotomy and the remaining 395 @entity0 were treated non-operatively. Twenty-two @entity0 were identified as having @entity5 , with 16 of them belonging to the operative group, and six to the non-operative group. A retrospective review of these six @entity0 and their characteristics, as well as pathogenesis, diagnosis, and the management of the liver abscesses, was conducted. RESULTS: These six @entity0 were all male, with a median age of 19.5 years (range 3-24). The median injury severity score was 16.5 (range 9-25); three @entity0 sustained grade-3 @entity1 , and the other three were grade 4. The main diagnostic tool was abdominal computed tomography, and the abscesses took a median of 6 days (range 1-12) to form and be diagnosed. The abscesses were usually caused by infection from mixed organisms, and an abscess resulting from @entity6 developed within 1 day after injury. These abscesses were treated with antibiotics and drainage, and the median length of hospital stay was 26 days (range 8-44), without mortality or long-term morbidity. CONCLUSION: @entity5 as a complication of the non-operative management of blunt @entity1 is a rare entity, with an incidence of 1.5% (6/395). It is usually seen in severe @entity1 (grade 3 and above), but all our @entity0 were all treated successfully, with no mortality. However, prolonged hospitalization may be required in this @entity0 group.

title: XXXX after non-operative management of blunt @entity1 .

answer: @entity5


abstract: UNASSIGNED: Whole-brain radiotherapy (WBRT) has been an important component of treatment for @entity1 ( @entity1 ), but delayed @entity3 has been a matter of concern. We have employed partial-brain radiotherapy (PBRT) with wide margins for @entity1 @entity0 with a single lesion or a few lesions. In this study, we evaluated the treatment outcome in @entity1 @entity0 undergoing PBRT. Between 2003 and 2014, 24 @entity0 were treated with PBRT; 16 received high-dose- @entity2 (MTX) -containing chemotherapy before PBRT. Conventional fractionation with a median dose of 54 Gy was used. For reference, 15 @entity0 undergoing MTX-based chemotherapy and WBRT were also analyzed. The 3-year overall survival rate was 60% for all 24 @entity0 undergoing PBRT and 68% for the 16 @entity0 undergoing MTX-based chemotherapy plus PBRT. The 3-year progression-free survival rate was 41% for all 24 @entity0 undergoing PBRT and 36% for the 16 @entity0 undergoing MTX-based chemotherapy. The in-field recurrence rate was 26% and the out-of-field recurrence rate was 15% at 3 years for all 24 @entity0 undergoing PBRT. The rates for in-field recurrence and the out-of-field recurrence were 27% and 21%, respectively, for the 16 @entity0 undergoing MTX-based chemotherapy. CNS-recurrence rates were similar in @entity0 undergoing MTX-based chemotherapy and PBRT to the rates in those undergoing MTX-based chemotherapy and WBRT. @entity1 developed in 3 of the 16 @entity0 undergoing MTX + PBRT and in 4 of 15 @entity0 undergoing MTX + WBRT (P = 0.68). PBRT seems to be a feasible treatment option for solitary @entity1 . Further investigations are warranted to evaluate the advantages of PBRT over WBRT.

title: Partial-brain radiotherapy for XXXX : multi-institutional experience.

answer: @entity1


abstract: OBJECTIVE: This study examined the impact of neoadjuvant chemotherapy and concurrent high-dose radiation therapy on survival in @entity0 with node-negative T3 and T4 @entity3 . METHODS: A total of 110 consecutive @entity0 underwent surgical resection for invasive T3N0M0 (94 @entity0 ) and T4N0M0 (16 @entity0 ) @entity3 between 1979 and 2008. Forty-seven @entity0 received neoadjuvant chemotherapy and concurrent high-dose (5940 cGy) radiation therapy before resection (Chemo-RT group). Sixty-three @entity0 underwent surgical resection without receiving induction chemoradiotherapy (Surg group), of whom 21 received neoadjuvant radiation, 19 received adjuvant radiation, 17 received surgery alone, 2 received adjuvant chemotherapy, 2 received adjuvant chemoradiotherapy, and 2 received brachytherapy. Survival of the Chemo-RT and Surg groups was compared using both crude and adjusted Cox proportional hazards models. RESULTS: The 5-year, 10-year, and median survivals were 61%, 50%, and 90 months, respectively, in the Chemo-RT group versus 22%, 14%, and 22 months, respectively, in the Surg group. Subjects in the Surg group had an increased risk of @entity2 (hazard ratio, 2.60; 95% confidence interval, 1.62-4.18; P  =  .0001) compared with the Chemo-RT group. After adjustment for potential confounding variables of age, sex, @entity1 size, @entity1 location, type of operation, and decade of care, subjects in the Surg group remained at increased risk of @entity2 (hazard ratio, 2.81; 95% confidence interval, 1.45-5.44, P  =  .002) compared with the Chemo-RT group. CONCLUSIONS: Aggressive treatment of node-negative invasive T3 and T4 NSCLC with induction chemoradiotherapy may significantly prolong survival. This approach should be evaluated in a prospective multicenter national trial.

title: Impact of neoadjuvant chemoradiotherapy followed by surgical resection on node-negative T3 and T4 XXXX .

answer: @entity3


abstract: The objective of this study was to establish the necessary protocols and assess the efficacy of @entity2 ( @entity3 ) as an antimicrobial intervention on beef @entity0 hides. Experiments using CPC were conducted to determine (i) the methods of neutralization needed to obtain valid efficacy measurements, (ii) the effect of concentration and dwell time after treatment, (iii) the effect of CPC on hide and carcass microbial populations when @entity0 were treated at a feedlot and then transported to a processing facility for harvest, and (iv) the effectiveness of spray pressure and two-spray combinations of CPC and water to reduce hide microbial populations. Residual CPC in hide sponge samples prevented bacterial growth. Dey-Engley neutralization media at 7.8% and a centrifugation step were necessary to overcome this problem. All dwell times, ranging from 30 s to 4 h, after 1% CPC application to @entity0 hides resulted in aerobic plate counts and Enterobacteriaceae counts 1.5 log CFU/100 cm2 lower than controls. The most effective dose of CPC was 1%, which reduced aerobic plate counts and Enterobacteriaceae counts 2 and 1 log CFU/100 cm2, respectively. Low-pressure application of 1% CPC at the feedlot, transport to the processing facility, and harvest within 5 h of application resulted in no effect on @entity1 O157 prevalence on hides or preevisceration carcasses. Two high-pressure CPC washes lowered aerobic plate counts and Enterobacteriaceae counts by 4 log CFU/100 cm2, and two medium-pressure CPC washes were only slightly less effective. These results indicate that under the proper conditions, CPC may still be effective for reducing microbial populations on @entity0 hides. Further study is warranted to determine if this effect will result in reduction of hide-to-carcass contamination during processing.

title: Protocol for evaluating the efficacy of XXXX as a beef hide intervention.

answer: @entity2


abstract: Stationary-phase @entity1 cells that were either pH dependent acid adapted or not acid adapted were heat challenged at 60 degrees C in a two-level full factorial design for three variables. The three variables and the levels consisted of tryptic soy broth (TSB) and sterile cell-free culture supernatant (sterile TSB), the presence and absence of 1% added @entity0 , and pH 4.8 and pH 7. Non-acid-adapted cells were most heat resistant when challenged in TSB (mean decimal reduction times at 60 degrees C: D60 = 1.16 min). In the absence of added @entity0 , non-acid-adapted cells had similar D60-values for inactivations at pH 4.8 and pH 7; however, the presence of @entity0 caused non-acid-adapted cells challenged at pH 4.8 to be more heat sensitive (D60 = 0.65 min) than those inactivated at pH 7 (D60 = 1.03 min), indicating an interaction between @entity0 and pH. Overall, the significantly decreased heat resistance of the acid-adapted cells was due to the presence of @entity0 (D60 = 0.78 min without @entity0 , D60 = 0.59 min with @entity0 ). Acid-adapted cells heat challenged in TSB had similar D60-values for inactivations at pH 4.8 and pH 7; however, acid-adapted cells in sterile TSB challenged at pH 4.8 (D60 = 0.52 min) had significantly lower heat resistance than did cells challenged at pH 7 (D60 = 0.76 min), indicating an interaction between the medium and pH. The @entity1 survivor data were modeled to extract information on the frequency distribution of heat resistance within heat-challenged populations, and the frequency distribution characteristics of mean, mode, and variance were compared among treatment conditions. Significant differences in the frequency distribution data were compared with the D60-values. These data indicated that the presence and level of cross-protection is highly dependent on the physiological state of the cells and nutrient availability at the time of heat challenge. Such conditions should be considered to ensure that stressed pathogens in foods are destroyed or inactivated.

title: Changes in heat resistance resulting from pH and nutritional shifts of acid-adapted and non-acid-adapted XXXX Scott A.

answer: @entity1


abstract: In view of the reported association of @entity2 ( @entity2 ) and ferritin, ferritin-bearing lymphocytes were followed during 2-year period in 79 @entity2 @entity0 . Indirect immunofluorescent method was used to evaluate the percentage of ferritin positive cells. In 22 untreated @entity0 a high percentage of ferritin-bearing circulating lymphocytes (mean value 37.3%) was found. In regard to the extent of the disease higher values were found in clinical stage III and IV (mean value 40.6%) as compared to the stage I and II (mean value 26.2%). Similarly, 17 @entity0 in relapse and with disease progression had mean values 41%. These proportions of cells were significantly lower in 44 @entity0 in complete remission with mean value of 8.7% (60 examinations). In 30 healthy controls the mean value was 1.4%. Repeatedly performed examinations of ferritin-bearing lymphocytes during the follow-up period in 17 @entity0 showed to be an important prognostic tool. A negative correlation of ferritin-bearing lymphocytes with E-rosette-forming cells was found. @entity1 content in peripheral blood lymphocytes was confirmed cytochemically after pre-incubation with antiferritin antibody. The results support the presumed role of ferritin in impaired cellular immunity in @entity2 and suggest diagnostic and prognostic value of the examination of ferritin-bearing lymphocytes in @entity2 .

title: Ferritin-bearing lymphocytes in XXXX .

answer: @entity2


abstract: OBJECTIVE: The objective was to analyse relationships between inspiratory and expiratory static and dynamic elastic pressure-volume (P(el)/V) curves in healthy @entity1 . DESIGN: The modulated low flow method was developed to allow studies also of the expiratory P(el)/V curves. Static P(el)/V (P(el,st)/V) and dynamic P(el)/V (P(el,dyn)/V) loops were studied in healthy @entity1 . SETTING: Animal research laboratory in a university hospital. MATERIAL: Ten healthy anaesthetised and paralysed @entity1 . INTERVENTIONS AND MEASUREMENTS: A computer controlled a Servo Ventilator 900C with respect to respiratory rate, inspiratory flow and expiratory pressure to achieve a sinusoidal modulation of inspiration and expiration for determination of P(el,dyn)/V loops from zero end-expiratory pressure (ZEEP) and from a positive end-expiratory pressure (PEEP) of 6 cm @entity2 to 20, 35 and 50 cm @entity2 . The same system was used for studies of P(el,st)/V loops with the flow-interruption method from ZEEP and @entity3 to 35 cm @entity2 . Recordings were analysed with an iterative technique. RESULTS: The feasibility of automated determination of P(el,dyn)/V loops was demonstrated. Differences between P(el,dyn)/V and P(el,st)/V loops were explained by viscoelastic behaviour. P(el,st)/V loops recorded from PEEP to 35 cm @entity2 showed no significant hysteresis, indicating a non-significant surface tension hysteresis. P(el,dyn)/V loops from PEEP and both P(el,st)/V and P(el,dyn)/V loops from ZEEP to 35 cm @entity2 showed hysteresis. This indicates that lung collapse/re-expansion caused P(el)/V loop hysteresis which, in P(el,dyn)/V loops, was augmented by viscoelastic behaviour. CONCLUSIONS: Viscoelasticity influences P(el,dyn)/V curves. Hysteresis caused by surface tension merits re-evaluation. @entity0 and re-expansion may be indicated by hysteresis of P(el)/V loops.

title: Dynamic elastic pressure-volume loops in healthy XXXX recorded with inspiratory and expiratory sinusoidal flow modulation. Relationship to static pressure-volume loops.

answer: @entity1


abstract: In this article two @entity0 are reported with recurrent upper airways and @entity2 . Laboratory investigation showed a persistent @entity3 . The @entity1 showed a normal cellularity of the erythroid series and the megakaryocytes. The myeloid series were normal with a decreased number of mature segmented neutrophils. In these patients the serum levels of immunoglobulins were within normal range and antibodies against the white cells could not be demonstrated. By the age of 2-3 years the recurrence of @entity2 had decreased and @entity2 of importance have not been reported since. By that age the peripheral white count was not abnormal. This combination of signs and symptoms is known as 'chronic @entity3 '. The etiology is obscure. Our investigation in one case (by that time recovered) showed a diminished growth of the myeloid series of donor bone marrow in the presence of patient's serum. This suggests a plasma-factor responsible for the maturation of the myeloid series. This finding has not yet been reported in the literature.

title: [Chronic XXXX possibly caused by a plasma factor].

answer: @entity3


abstract: The aim of this study was to determine the prevalence of signs and symptoms of @entity3 in @entity0 with @entity2 ( @entity2 ) occurring as a consequence of exposure to war stress. The examined group consisted of 100 male subjects, aged from 25 to 50 years, who had taken part in the War in Croatia, and in whom @entity2 had previously been diagnosed. The control group comprised 100 subjects, without @entity2 , of the same sex and age group, who had not taken part in the War. A functional evaluation of the stomatognathic system was performed using the Helkimo Anamnestic and Clinical Dysfunction Index. Eighty-two per cent of the group with @entity2 had at least one symptom, and 98% at least one sign of @entity1 . Eight per cent reported mild symptoms and 74% severe symptoms. Twenty-eight per cent showed mild clinical signs, 22% had signs of moderate, and 48% of severe @entity1 . Twenty-four per cent of the control group of subjects had at least one symptom, and 52% at least one clinical sign of @entity1 . Twenty-two per cent reported mild and 2% severe symptoms. Mild clinical signs of @entity1 were found in 50% of subjects in the control group, moderate in 2% and none exhibited severe clinical signs. It is concluded that correlation exists between war stress and @entity3 .

title: The influence of war stress on the prevalence of signs and symptoms of XXXX .

answer: @entity3


abstract: OBJECTIVE: The objective of this study was to determine the relationship between drug-related problems (DRPs) and health-related quality-of-life (HRQoL) in ambulatory, community-dwelling @entity0 with @entity1 . METHODS: A 12-month, prospective, observational study was conducted in 12 independent community pharmacies in eastern Iowa. Ambulatory @entity0 with self-reported diagnoses of @entity3 , @entity2 , or @entity6 were invited to participate. During quarterly visits to the pharmacy, @entity0 used touch-screen computers to fill out the Short Form-36 (SF-36) general health survey. Using the results of these point-of-service health status assessments, community pharmacists interviewed @entity0 to assess for DRPs. To examine the influences of different DRP characteristics on HRQoL and controlling for potential confounders, both univariate and multivariate analyses were performed using the change in physical component summary (PCS) score and @entity5 ( @entity5 ) score of the SF-36 from baseline to 12 months as the dependent variables. In each regression, the independent variables were those significant variables from the univariate analyses, as well as the types of DRPs and their outcomes. RESULTS: A total of 461 @entity0 were enrolled in the study. Through 12 months, 926 cumulative DRPs were identified. Overall regression models were significant for the PCS and @entity5 scores, respectively. Two types of DRPs showed significant negative associations with change in PCS: wrong drug and needs additional drug therapy. One type of DRP showed significant negative association with change in @entity5 : needs additional drug therapy. Resolution or improvement in DRPs showed a significant positive correlation with change in @entity5 but not PCS. CONCLUSIONS: Two DRPs, needs additional drug therapy and wrong drug, are associated with reduced self-reported physical health in @entity4 and @entity6 , while the DRP needs additional drug therapy is also associated with reduced self-reported mental health. Resolution of DRPs is associated with improvement in mental health in this cohort.

title: Drug-related problems and quality of life in @entity4 and XXXX sufferers.

answer: @entity6


abstract: OBJECTIVE: The objective of this study was to determine the relationship between drug-related problems (DRPs) and health-related quality-of-life (HRQoL) in ambulatory, community-dwelling @entity0 with @entity1 . METHODS: A 12-month, prospective, observational study was conducted in 12 independent community pharmacies in eastern Iowa. Ambulatory @entity0 with self-reported diagnoses of @entity3 , @entity2 , or @entity6 were invited to participate. During quarterly visits to the pharmacy, @entity0 used touch-screen computers to fill out the Short Form-36 (SF-36) general health survey. Using the results of these point-of-service health status assessments, community pharmacists interviewed @entity0 to assess for DRPs. To examine the influences of different DRP characteristics on HRQoL and controlling for potential confounders, both univariate and multivariate analyses were performed using the change in physical component summary (PCS) score and @entity5 ( @entity5 ) score of the SF-36 from baseline to 12 months as the dependent variables. In each regression, the independent variables were those significant variables from the univariate analyses, as well as the types of DRPs and their outcomes. RESULTS: A total of 461 @entity0 were enrolled in the study. Through 12 months, 926 cumulative DRPs were identified. Overall regression models were significant for the PCS and @entity5 scores, respectively. Two types of DRPs showed significant negative associations with change in PCS: wrong drug and needs additional drug therapy. One type of DRP showed significant negative association with change in @entity5 : needs additional drug therapy. Resolution or improvement in DRPs showed a significant positive correlation with change in @entity5 but not PCS. CONCLUSIONS: Two DRPs, needs additional drug therapy and wrong drug, are associated with reduced self-reported physical health in @entity4 and @entity6 , while the DRP needs additional drug therapy is also associated with reduced self-reported mental health. Resolution of DRPs is associated with improvement in mental health in this cohort.

title: Drug-related problems and quality of life in XXXX and @entity6 sufferers.

answer: @entity4


abstract: BACKGROUND AND PURPOSE: The best strategy for treatment of @entity4 due to @entity7 is obliteration of the @entity3 as soon as possible. Early surgery is desirable if the @entity0 does not develop severe @entity8 or is clinically stable. However, if the @entity0 has already developed severe @entity8 on admission, surgery may carry the risk of increasing the severity. We evaluated the safety and effectiveness of combined Guglielmi detachable coil (GDC) @entity5 and angioplasty in a single session for the treatment of @entity7 associated with symptomatic @entity8 . METHODS: From January 1992 to January 2001, 12 consecutive @entity0 with @entity7 associated with symptomatic @entity8 were treated. @entity0 were classified as Hunt and Hess grade 2 (n = 1), 3 (n = 6), 4 (n = 4), or 5 (n = 1) and Fisher CT group 2 (n = 1), 3 (n = 10), or 4 (n = 1). They underwent GDC @entity3 and balloon angioplasty (n = 6), intraarterial papaverine infusion (n = 2), or both (n = 4) in a single session. In nine @entity0 , @entity3 coil occlusion was performed first. RESULTS: @entity2 was achieved in eight @entity0 , a small neck remnant persisted in three, and @entity5 was incomplete in one @entity0 . In all @entity0 , angiographic improvement of @entity8 was obtained. In one @entity0 , a @entity6 occurred and was treated with urokinase. Clinical outcomes at discharge were good recovery in six, moderate disability in two, severe disability in three, or @entity1 in one. CONCLUSION: Endovascular treatment can be the first therapeutic option for @entity7 associated with severe @entity8 on admission. It offers some advantages over surgery in this setting, but these are balanced by the risk of @entity6 .

title: Combined endovascular treatment for both intracranial aneurysm and symptomatic XXXX .

answer: @entity8


abstract: BACKGROUND: @entity1 is occasionally detected on routine imaging studies in healthy hosts with no or mild symptoms. Isolated @entity1 may be observed without specific therapy in asymptomatic immunocompetent hosts. However, considering that dissemination from a @entity1 can occur in @entity0 with no immunologic defects, treatment of asymptomatic @entity1 in immunocompetent hosts remains controversial. The aim of this study was to determine the role of @entity2 therapy in the management of isolated @entity1 in asymptomatic healthy hosts. METHODS: We retrospectively analyzed the medical records and radiographic findings of 10 healthy subjects with isolated @entity1 diagnosed incidentally and treated with oral @entity2 . RESULTS: All @entity0 had no respiratory or constitutional symptoms. The most common radiological findings were pulmonary nodules, and the number of nodules in each @entity0 was from 1 to 9. After histological confirmation, all @entity0 were treated with oral @entity2 at a dosage of 400 mg per day for a median period of 6.4 months. No @entity0 developed an adverse reaction to @entity2 . The mean interval between the initiation of antifungal therapy and final radiological response was 8.3 months. Seven of the 10 @entity0 showed complete resolution, and the other 3 @entity0 were assessed as having partial resolution. During the average follow-up period of 11.9 months, all @entity0 showed a favourable outcome with no relapse. The overall cure rate was 70%. CONCLUSION: These results suggest that @entity2 may be an attractive therapeutic option for asymptomatic @entity1 in immunocompetent hosts.

title: Treatment of asymptomatic XXXX in immunocompetent hosts with oral @entity2 .

answer: @entity1


abstract: BACKGROUND: @entity1 is occasionally detected on routine imaging studies in healthy hosts with no or mild symptoms. Isolated @entity1 may be observed without specific therapy in asymptomatic immunocompetent hosts. However, considering that dissemination from a @entity1 can occur in @entity0 with no immunologic defects, treatment of asymptomatic @entity1 in immunocompetent hosts remains controversial. The aim of this study was to determine the role of @entity2 therapy in the management of isolated @entity1 in asymptomatic healthy hosts. METHODS: We retrospectively analyzed the medical records and radiographic findings of 10 healthy subjects with isolated @entity1 diagnosed incidentally and treated with oral @entity2 . RESULTS: All @entity0 had no respiratory or constitutional symptoms. The most common radiological findings were pulmonary nodules, and the number of nodules in each @entity0 was from 1 to 9. After histological confirmation, all @entity0 were treated with oral @entity2 at a dosage of 400 mg per day for a median period of 6.4 months. No @entity0 developed an adverse reaction to @entity2 . The mean interval between the initiation of antifungal therapy and final radiological response was 8.3 months. Seven of the 10 @entity0 showed complete resolution, and the other 3 @entity0 were assessed as having partial resolution. During the average follow-up period of 11.9 months, all @entity0 showed a favourable outcome with no relapse. The overall cure rate was 70%. CONCLUSION: These results suggest that @entity2 may be an attractive therapeutic option for asymptomatic @entity1 in immunocompetent hosts.

title: Treatment of asymptomatic @entity1 in immunocompetent hosts with oral XXXX .

answer: @entity2


abstract: OBJECTIVES: To report the outcomes of two-stage repair for @entity5 using a buccal mucosa graft as a tube. METHODS: A total of 57 adult @entity0 who underwent surgery for severe @entity6 at our institution from January 2002 to March 2010 were included in this analysis. The urethroplasty procedure included penile urethra reconstruction with the buccal mucosa graft used as a tube in the first stage, @entity3 of the unobstructed urethra in the second stage and a scrotal fascio-cutaneous flap transferred to resurface the reconstructed urethra for waterproofing. RESULTS: No complications occurred after the first stage, whereas @entity2 occurred in six cases and @entity1 occurred in two cases after the second stage. All eight of these @entity0 had the complication of @entity4 , which healed after 2-4 weeks by cleaning and changing dressings in six @entity0 . Twelve @entity0 complained of straining at voiding in the early postoperative period. However, nine of these @entity0 had an obvious increase in maximum flow rate without any intervention 3 months after the operation. Follow up ranged from 6 to 62 months (mean 28 months) in 46 @entity0 . Most of the @entity0 presented terminal meatus, no chordee, no urethral stricture and normal voiding. The majority of @entity0 achieved excellent cosmetic and functional results. CONCLUSIONS: A buccal mucosa graft as a tube is a reliable and durable method of two-stage repair for severe and complicated @entity5 in adults. The use of scrotal flaps seems to contribute to a good vascularized waterproof cover.

title: Two-stage repair with buccal mucosa for severe and complicated XXXX in adults.

answer: @entity5


abstract: @entity3 ( @entity3 ) is a major cause of morbidity and mortality following allogeneic bone marrow transplantation (BMT). We studied 159 @entity0 with @entity3 longitudinally to characterize the natural history of @entity3 and identify reliable predictors of response and long-term mortality. Rates of response to treatment were 61%, 53%, and 50% at 6 months, 1 year, and 2 years, respectively. A high incidence of @entity2 (7 of 1,000 @entity0 -days at 0 to 6 months, 2.5 of 1,000 @entity0 -days at 6 months to 1 year, and 0.6 of 1,000 @entity0 -days at 1 to 2 years) was observed. After a median follow-up of 8.4 years, an overall survival rate of 40% was observed. The overall survival rate was 63% (95% confidence interval [CI], 56%-71%) at 1 year, 51% (95% CI, 43%-59%) at 2 years, and 39% (95% CI, 31%-47%) at 10 years. In multivariate analysis, age older than 20 years (RR = 1.5; 95% CI, 0.9%-2.5%; P =.09), progressive onset of @entity3 (RR = 1.6; 95% CI, 1.0%-2.4%; P =.04), platelet count of <100,000/ microL (RR = 2.1; 95% CI, 1.3%-3.4%; P =.001), and GI involvement (RR = 1.5; 95% CI, 1.0%-2.4%; P =.05) were associated with increased mortality. Among @entity0 surviving more than 6 months, no response (RR = 4.5; 95% CI, 1.9%-10.5%; P =.0006) and partial response (RR = 2.5; 95% CI, 1.1%-6.1%; P =.04) to treatment at 6 months also were significant predictors of mortality. The prevalence of active @entity3 was 33% at 2 years. However, the cumulative incidence of successful discontinuation of therapy was only 13% at 2 years. Among @entity0 with clinical resolution of @entity3 , only 18% were off immunosuppressive therapy by 2 years, and 89% by 4 years. Despite high initial response rates, a large majority of @entity0 had active disease requiring prolonged immunosuppression. This requires improved infection prevention for a longer time. Recognition of a high-risk group should facilitate assignment of more intensified regimens. Better treatment regimens need to be identified to improve survival and limit @entity1 of prolonged immunosuppression.

title: XXXX : a prospective cohort study.

answer: @entity3


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity4 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity10 (Trip). The present study was to investigate the effect of Trip on @entity0 in a model of @entity6 ( @entity6 ). METHODS: @entity6 or sham-operated @entity1 were randomly assigned to receive @entity3 ( @entity8 ), Trip or vehicle and were killed on days 7 and 14 after @entity6 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity5 ( @entity5 ) and osteopontin. Interstitial collagen deposition and amounts of @entity7 ( @entity7 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity7 , @entity9 ( @entity9 ), @entity5 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity5 and osteopontin, interstitial collagen deposition and amounts of @entity7 were significantly reduced by @entity8 or Trip. @entity8 or Trip significantly reduced the mRNA expression of @entity7 , @entity9 , @entity5 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity2 in a @entity1 @entity6 model and the effect of Trip on @entity0 was similar to that of @entity8 . Trip may be useful as a potential candidate in the treatment of @entity0 .

title: @entity10 attenuates XXXX in @entity1 with @entity6 .

answer: @entity0


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity4 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity10 (Trip). The present study was to investigate the effect of Trip on @entity0 in a model of @entity6 ( @entity6 ). METHODS: @entity6 or sham-operated @entity1 were randomly assigned to receive @entity3 ( @entity8 ), Trip or vehicle and were killed on days 7 and 14 after @entity6 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity5 ( @entity5 ) and osteopontin. Interstitial collagen deposition and amounts of @entity7 ( @entity7 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity7 , @entity9 ( @entity9 ), @entity5 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity5 and osteopontin, interstitial collagen deposition and amounts of @entity7 were significantly reduced by @entity8 or Trip. @entity8 or Trip significantly reduced the mRNA expression of @entity7 , @entity9 , @entity5 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity2 in a @entity1 @entity6 model and the effect of Trip on @entity0 was similar to that of @entity8 . Trip may be useful as a potential candidate in the treatment of @entity0 .

title: XXXX attenuates @entity0 in @entity1 with @entity6 .

answer: @entity10


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity4 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity10 (Trip). The present study was to investigate the effect of Trip on @entity0 in a model of @entity6 ( @entity6 ). METHODS: @entity6 or sham-operated @entity1 were randomly assigned to receive @entity3 ( @entity8 ), Trip or vehicle and were killed on days 7 and 14 after @entity6 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity5 ( @entity5 ) and osteopontin. Interstitial collagen deposition and amounts of @entity7 ( @entity7 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity7 , @entity9 ( @entity9 ), @entity5 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity5 and osteopontin, interstitial collagen deposition and amounts of @entity7 were significantly reduced by @entity8 or Trip. @entity8 or Trip significantly reduced the mRNA expression of @entity7 , @entity9 , @entity5 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity2 in a @entity1 @entity6 model and the effect of Trip on @entity0 was similar to that of @entity8 . Trip may be useful as a potential candidate in the treatment of @entity0 .

title: @entity10 attenuates @entity0 in @entity1 with XXXX .

answer: @entity6


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity4 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity10 (Trip). The present study was to investigate the effect of Trip on @entity0 in a model of @entity6 ( @entity6 ). METHODS: @entity6 or sham-operated @entity1 were randomly assigned to receive @entity3 ( @entity8 ), Trip or vehicle and were killed on days 7 and 14 after @entity6 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity5 ( @entity5 ) and osteopontin. Interstitial collagen deposition and amounts of @entity7 ( @entity7 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity7 , @entity9 ( @entity9 ), @entity5 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity5 and osteopontin, interstitial collagen deposition and amounts of @entity7 were significantly reduced by @entity8 or Trip. @entity8 or Trip significantly reduced the mRNA expression of @entity7 , @entity9 , @entity5 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity2 in a @entity1 @entity6 model and the effect of Trip on @entity0 was similar to that of @entity8 . Trip may be useful as a potential candidate in the treatment of @entity0 .

title: @entity10 attenuates @entity0 in XXXX with @entity6 .

answer: @entity1


abstract: BACKGROUND: Surgical stress elicits a characteristic response involving induction of synthesis and release of acute-phase proteins such as @entity5 ( @entity5 ). To objectively evaluate the surgical stress in @entity0 with asymptomatic @entity3 , serum levels of @entity5 after direct clipping via the pterional approach were measured. METHODS: 42 @entity0 who experienced an uneventful postoperative course, were evaluated according to age (less or more than 65 years old [adult or elderly]), aneurysmal location (middle cerebral artery territory [MC], anterior communicating artery [Acom] or internal carotid artery territory [ @entity6 ]) and intraoperative @entity1 (positive or negative). We defined intraoperative @entity1 as intentional vein cutting, perforator vessel injury or suction of the gyrus rectus. All @entity0 received standardized general anesthesia and were treated after the operations according to our standard protocols. Serum levels of @entity5 on postoperative day 2 were compared in each category. RESULTS: Serum levels of @entity5 showed no significant difference between the adult group and the elderly group, but were greater in Acom @entity0 than in MC and @entity6 @entity0 (p < 0.01, p < 0.05). As to intraoperative @entity1 , the positive group (almost all were intentional vein cutting) showed greater @entity5 levels than the negative group in MC and @entity6 @entity0 (p < 0.05). Operation time and volume of @entity2 were almost the same in each category. CONCLUSION: Our study shows that as far as serum levels of @entity5 are concerned, Acom location and vein cutting are the main factors of surgical stress in cases of @entity4 .

title: [Surgical stress in @entity0 with asymptomatic XXXX ].

answer: @entity3


abstract: BACKGROUND: Surgical stress elicits a characteristic response involving induction of synthesis and release of acute-phase proteins such as @entity5 ( @entity5 ). To objectively evaluate the surgical stress in @entity0 with asymptomatic @entity3 , serum levels of @entity5 after direct clipping via the pterional approach were measured. METHODS: 42 @entity0 who experienced an uneventful postoperative course, were evaluated according to age (less or more than 65 years old [adult or elderly]), aneurysmal location (middle cerebral artery territory [MC], anterior communicating artery [Acom] or internal carotid artery territory [ @entity6 ]) and intraoperative @entity1 (positive or negative). We defined intraoperative @entity1 as intentional vein cutting, perforator vessel injury or suction of the gyrus rectus. All @entity0 received standardized general anesthesia and were treated after the operations according to our standard protocols. Serum levels of @entity5 on postoperative day 2 were compared in each category. RESULTS: Serum levels of @entity5 showed no significant difference between the adult group and the elderly group, but were greater in Acom @entity0 than in MC and @entity6 @entity0 (p < 0.01, p < 0.05). As to intraoperative @entity1 , the positive group (almost all were intentional vein cutting) showed greater @entity5 levels than the negative group in MC and @entity6 @entity0 (p < 0.05). Operation time and volume of @entity2 were almost the same in each category. CONCLUSION: Our study shows that as far as serum levels of @entity5 are concerned, Acom location and vein cutting are the main factors of surgical stress in cases of @entity4 .

title: [Surgical stress in XXXX with asymptomatic @entity3 ].

answer: @entity0


abstract: BACKGROUND: Malignant perivascular epitheliod cell @entity1 ( @entity6 ) is a very rare entity composed of distinctive perivascular epitheliod cells with variable immunoreactivity for melanocytic and muscle markers. At present this @entity1 does not have a known normal cellular counterpart and the natural history is often unpredictable. Up to now, few cases of @entity6 have been described and treatment modalities are still controversial, particularly in advanced conditions. CASE PRESENTATION: We handled the case of a 42-year-old @entity0 with unresectable @entity6 of the abdomen. A 7 cm hepatic hypodense lesion between segment V and @entity4 of the liver and diffuse intraperitoneal nodules of 0,3-3,5 cm along the right subcapsular hepatic region, were documented by a CT scan. Radiological images showed abnormal lymph nodes of the right internal mammary chain and anterior @entity7 . The @entity0 underwent an explorative laparotomy for uncontrolled @entity3 without a well-defined preoperative @entity1 diagnosis. At surgery, multiple lobulated nodules containing hemorrhagic fluid on the liver surface, peritoneum and omentum were confirmed. The procedure had a palliative intent and consisted of hemostasis, @entity5 evacuation and omentectomy. The diagnosis of @entity6 was made after surgery on the basis of morphological and immunohistochemical criteria. Radiological and intra operative findings suggest that the mass has an hepatic origin with diffuse involvement of hepatic capsule and suspensory ligaments. The @entity0 received medical support care with blood and plasma transfusions. In our experience, @entity6 was clinically malignant, leading to a fatal outcome 25 days after hospital admission of @entity0 . CONCLUSIONS: Here we report and discuss the peculiar clinical, radiological and morphological presentation of unresectable @entity6 . Although in the majority of the reported series, @entity6 show a more better prognosis, our case presents with a particular @entity2 biological behaviour. The importance of a correct preoperative diagnosis, the need for more effective targeted therapies based on @entity1 molecular knowledge and evidence-based clinical studies are emphasized together with a revision of the concerning scientific literature.

title: XXXX : a case report with emphasis on clinical and morphological criteria.

answer: @entity1


abstract: The life expectancy of @entity0 with @entity2 ( @entity2 ) has increased. A cross-sectional study of @entity2 @entity0 showed that 54 % of 13-year-old @entity0 are @entity1 and that 54 % of 18-year-old @entity0 are underweight. We aimed to describe the natural evolution of weight status in @entity2 . This retrospective multi-centre audit collected body-weight measurements for seventy @entity2 @entity0 born before 1992. The body-weight:age ratio (W:A) was used to evaluate weight status in reference to the Griffiths and Edwards chart. At the age of 13 years, 73 % were @entity1 and 4 % were underweight. At maximal follow-up (age 15-26 years, mean 18  3 (sd 2  3) years), 47 % were @entity1 and 34 % were underweight. Obesity at the age of 13 years was associated with @entity1 , whereas normal weight status and underweight in 13-year-old @entity0 predicted later underweight. A W:A >=  151 % in 13-year-old @entity0 predicted @entity1 , and a W:A  <= 126  5 % predicted later underweight. Our audit provides the first longitudinal information about the spontaneous outcome of weight status in @entity2 . @entity0 (13 years old) with a W:A >=  151 % were more likely to become @entity1 in late adolescence, but @entity1 prevented later underweight. These data suggest that mild @entity1 in 13-year-old @entity2 @entity0 (W:A between 120 and 150 %) should not be discouraged because it prevents later underweight.

title: Natural evolution of weight status in XXXX : a retrospective audit.

answer: @entity2


abstract: BACKGROUND: Little is known about @entity0 ' views on taking selective @entity1 -reuptake inhibitors (SSRIs) and their decision-making processes regarding either continuation or discontinuation within a few months of initiating therapy. OBJECTIVE: To explore the experiences and beliefs of SSRI users in relation to initiation and execution of treatment, with the intention to identify patterns leading to discontinuation or continuation of treatment. METHODS: Semistructured qualitative interview study. Eighteen @entity0 , older than 18 years, were interviewed 3 months after starting SSRI treatment prescribed by a general practitioner (GP), 9 of whom had discontinued (discontinuers) and 9 of whom continued treatment (continuers). RESULTS: Two main patterns lead to either discontinuation or continuation of use. Continuers were satisfied with the GP's role during initiation and execution of SSRI treatment and fully trusted their decision. Continuers' attitudes toward treatment were predominantly positive; they seemed to have little doubt about the necessity of using an SSRI and hardly considered discontinuing for fear of relapse. Discontinuers, on the other hand, seemed to be less involved in decision making and often appeared to have little confidence in their GPs. Most discontinuers felt that they lacked knowledge, and their attitude toward taking SSRIs was rather negative. Discontinuers often were unconvinced about the necessity of using an SSRI and appeared to have a strong desire to discontinue treatment. CONCLUSION: Lack of shared decision making between @entity0 and GP, limited counseling during treatment, lack of knowledge, and @entity0 ' negative attitudes toward SSRI use and the disease itself, hampered the acceptance of the SSRI and brought on the decisional conflict to discontinue treatment. Health care professionals could be more supportive during the initial months of SSRI treatment by eliciting @entity0 ' considerations for continuing or discontinuing treatment.

title: The decision to continue or discontinue treatment: experiences and beliefs of users of selective XXXX -reuptake inhibitors in the initial months--a qualitative study.

answer: @entity1


abstract: OBJECTIVE: To examine the outcome of assisted reproduction techniques (ART) using cryopreserved semen from @entity0 with @entity1 . DESIGN: Prospective. SETTING: Therapeutic semen banking program at a tertiary healthcare center. @entity0 (S): Twenty-nine @entity0 with @entity1 who cryopreserved their sperm before treatment at our facility from 1982 to 2001 and withdrew their samples for assisted reproduction (IUI, IVF, or intracytoplasmic sperm injection [ICSI]). INTERVENTION(S): Sperm bank records were used to identify the @entity0 . Information on fertility potential indices was obtained from medical records and through interviews. Of the 29 @entity0 , 9 had @entity1 , 12 had @entity3 , and 8 had other types of @entity1 . MAIN OUTCOME MEASURE(S): Pregnancy and live births. RESULT(S): A total of 87 ART cycles (42 IUI, 26 IVF, and 19 ICSI) was performed. Of those cycles, 18.3% resulted in pregnancy (7% IUI, 23% IVF, and 37% ICSI), and 75% of the pregnancies resulted in a live birth (100% IUI, 83% IVF, and 57% ICSI). There was no significant difference in the outcomes when the results were stratified by type of ART and @entity1 . None of the 11 @entity0 who were born had @entity2 . CONCLUSION(S): Our findings emphasize the need for physicians to discuss the issue of semen cryopreservation with all @entity0 of reproductive age who have @entity1 before antineoplastic therapy is started.

title: Fertility after XXXX : a prospective review of assisted reproductive outcome with banked semen specimens.

answer: @entity1


abstract: BACKGROUND: Most dietary pattern analyses in southern Europe have relied on a priori food approaches using Mediterranean-style diet indexes. These methods may not reflect the current population's food consumption. OBJECTIVE: To assess the association of a posteriori dietary patterns with @entity4 ( @entity4 ) and cardiovascular risk markers in the general adult population of Porto, Portugal. DESIGN: A population-based case-control study was conducted. Information was collected by trained interviewers. Diet was assessed with a validated 82-item food frequency questionnaire. @entity0 /SETTING: Cases were @entity0 consecutively hospitalized for an incident non-fatal @entity4 (n=820), and controls were individuals free of previous @entity4 selected from the hospitals' catchment area (n=2,196). STATISTICAL ANALYSES: Dietary patterns, representing mutually exclusive clusters of individuals, were identified by multivariate finite mixture models among controls. Odds ratios (OR) and their 95% confidence intervals (CIs) were obtained from unconditional logistic regression, with adjustment for main confounders. RESULTS: In comparison to @entity0 with a "healthy" dietary pattern, those with a "low fruit and vegetables" pattern and a "red meat and alcohol" (also characterized by lower intake of dairy products and vegetables) pattern showed a higher risk of @entity4 (OR 1.85, 95% CI 1.01 to 3.39 and OR 1.91, 95% CI 1.17 to 3.12, respectively). Female controls with the "red meat and alcohol" pattern also had a higher total to high-density lipoprotein @entity1 ratio. In comparison to @entity0 with a "healthy" pattern, those with the "red meat and alcohol" pattern, similar to the counterpart found in @entity0 , were more likely to experience an @entity4 (OR 1.98, 95% CI 1.35 to 2.92); male controls with this pattern had higher diastolic and systolic blood pressure, @entity5 , and @entity3 levels. CONCLUSIONS: A dietary pattern with lower fruit and vegetable intakes in @entity0 , and a pattern characterized by higher consumption of red meat and @entity2 (and lower of dairy products and vegetables) in both sexes, were associated with an increased risk of @entity4 and adverse cardiovascular risk profiles. These findings highlight the importance of sustained recommendations for fruit and vegetable intake and cautious guidance on consumption of alcoholic beverages, which clusters with less healthy dietary patterns of @entity0 and @entity0 .

title: Major habitual dietary patterns are associated with XXXX and cardiovascular risk markers in a southern European population.

answer: @entity4


abstract: PURPOSE: To analyze, in a prospective clinical trial, the efficacy and @entity4 of concurrent radiotherapy and chemotherapy with @entity3 and @entity7 in @entity0 with incompletely (R1) resected @entity5 . METHODS AND MATERIALS: Between 2000 and 2002, a total of 30 @entity5 @entity0 were treated. Radiotherapy was performed in 15 @entity0 up to a total dose of 45.0 Gy. An additional 15 @entity0 received a total dose of 50.0 Gy according to the International Commission on Radiation Units and Measurements (ICRU) Report 50 reference point (equivalent to 45.0 Gy at the isodose, including 90% covering the former @entity2 area and local lymph nodes). Concurrent with radiotherapy, four applications of @entity3 (300 mg/m(2)) and @entity7 (30 mg/m(2)) were administered. After chemoradiotherapy, @entity0 received four additional courses of @entity3 (1000 mg/m(2)) and @entity7 (50 mg/m(2)) on Days 1 and 15 in a 4-week cycle. RESULTS: The median progression-free survival was 10.6 months, and the median overall survival was 22.8 months. The 1-, 2-, and 3-year survival rate was 81%, 43%, and 26%, respectively. After completion of chemoradiotherapy, distant @entity1 was observed in 14 @entity0 during a median follow-up of 15.0 months (range, 4.6-30.0). One @entity0 developed both local recurrence and distant metastases. Hematologic @entity4 were the most prominent side effects ( @entity8 Grade 3 and 4 in 53% and 7% and @entity6 Grade 3 and 4 in 33% and 7% of @entity0 , respectively). Grade 3 and 4 @entity4 was not observed. CONCLUSION: Postoperative chemoradiotherapy with @entity3 and @entity7 after incomplete (R1) resection of @entity9 is safe and feasible. A prolonged progression-free survival suggests high local efficacy, translating into a benefit of overall survival. On the basis of the favorable outcome of @entity0 receiving @entity3 / @entity7 -based chemoradiotherapy, testing this combined treatment strategy appears warranted in a comparative trial.

title: Concurrent chemoradiotherapy with @entity3 and XXXX after incomplete (R1) resection of locally advanced @entity9 .

answer: @entity7


abstract: PURPOSE: To analyze, in a prospective clinical trial, the efficacy and @entity4 of concurrent radiotherapy and chemotherapy with @entity3 and @entity7 in @entity0 with incompletely (R1) resected @entity5 . METHODS AND MATERIALS: Between 2000 and 2002, a total of 30 @entity5 @entity0 were treated. Radiotherapy was performed in 15 @entity0 up to a total dose of 45.0 Gy. An additional 15 @entity0 received a total dose of 50.0 Gy according to the International Commission on Radiation Units and Measurements (ICRU) Report 50 reference point (equivalent to 45.0 Gy at the isodose, including 90% covering the former @entity2 area and local lymph nodes). Concurrent with radiotherapy, four applications of @entity3 (300 mg/m(2)) and @entity7 (30 mg/m(2)) were administered. After chemoradiotherapy, @entity0 received four additional courses of @entity3 (1000 mg/m(2)) and @entity7 (50 mg/m(2)) on Days 1 and 15 in a 4-week cycle. RESULTS: The median progression-free survival was 10.6 months, and the median overall survival was 22.8 months. The 1-, 2-, and 3-year survival rate was 81%, 43%, and 26%, respectively. After completion of chemoradiotherapy, distant @entity1 was observed in 14 @entity0 during a median follow-up of 15.0 months (range, 4.6-30.0). One @entity0 developed both local recurrence and distant metastases. Hematologic @entity4 were the most prominent side effects ( @entity8 Grade 3 and 4 in 53% and 7% and @entity6 Grade 3 and 4 in 33% and 7% of @entity0 , respectively). Grade 3 and 4 @entity4 was not observed. CONCLUSION: Postoperative chemoradiotherapy with @entity3 and @entity7 after incomplete (R1) resection of @entity9 is safe and feasible. A prolonged progression-free survival suggests high local efficacy, translating into a benefit of overall survival. On the basis of the favorable outcome of @entity0 receiving @entity3 / @entity7 -based chemoradiotherapy, testing this combined treatment strategy appears warranted in a comparative trial.

title: Concurrent chemoradiotherapy with XXXX and @entity7 after incomplete (R1) resection of locally advanced @entity9 .

answer: @entity3


abstract: PURPOSE: To analyze, in a prospective clinical trial, the efficacy and @entity4 of concurrent radiotherapy and chemotherapy with @entity3 and @entity7 in @entity0 with incompletely (R1) resected @entity5 . METHODS AND MATERIALS: Between 2000 and 2002, a total of 30 @entity5 @entity0 were treated. Radiotherapy was performed in 15 @entity0 up to a total dose of 45.0 Gy. An additional 15 @entity0 received a total dose of 50.0 Gy according to the International Commission on Radiation Units and Measurements (ICRU) Report 50 reference point (equivalent to 45.0 Gy at the isodose, including 90% covering the former @entity2 area and local lymph nodes). Concurrent with radiotherapy, four applications of @entity3 (300 mg/m(2)) and @entity7 (30 mg/m(2)) were administered. After chemoradiotherapy, @entity0 received four additional courses of @entity3 (1000 mg/m(2)) and @entity7 (50 mg/m(2)) on Days 1 and 15 in a 4-week cycle. RESULTS: The median progression-free survival was 10.6 months, and the median overall survival was 22.8 months. The 1-, 2-, and 3-year survival rate was 81%, 43%, and 26%, respectively. After completion of chemoradiotherapy, distant @entity1 was observed in 14 @entity0 during a median follow-up of 15.0 months (range, 4.6-30.0). One @entity0 developed both local recurrence and distant metastases. Hematologic @entity4 were the most prominent side effects ( @entity8 Grade 3 and 4 in 53% and 7% and @entity6 Grade 3 and 4 in 33% and 7% of @entity0 , respectively). Grade 3 and 4 @entity4 was not observed. CONCLUSION: Postoperative chemoradiotherapy with @entity3 and @entity7 after incomplete (R1) resection of @entity9 is safe and feasible. A prolonged progression-free survival suggests high local efficacy, translating into a benefit of overall survival. On the basis of the favorable outcome of @entity0 receiving @entity3 / @entity7 -based chemoradiotherapy, testing this combined treatment strategy appears warranted in a comparative trial.

title: Concurrent chemoradiotherapy with @entity3 and @entity7 after incomplete (R1) resection of locally advanced XXXX .

answer: @entity9


abstract: Luteinizing hormone (LH) concentrations and pulsatility are increased in @entity1 @entity0 with @entity6 ( @entity6 ). In addition, @entity0 have @entity6 and insulin resistance. The mechanisms involved in aberrant hormone regulation in @entity6 are still unclear. We investigated 15 @entity6 @entity0 with a body mass index between 30 and 54 kg/m(2) and 9 healthy @entity1 controls (body mass index, 31-60 kg/m(2)) with regular menstrual cycles. Subjects underwent 24-hour blood sampling at 10-minute intervals for later measurements of LH, leptin, @entity3 , and insulin concentrations. Data were analyzed with a new deconvolution program, approximate entropy (and bivariate approximate entropy), and a cross-correlation network. @entity0 had increased LH pulse frequency and more than 2-fold greater daily LH secretion, with diminished pattern regularity. @entity3 secretion was increased 2-fold, but pattern regularity was similar to that in controls. In the network construct, insulin was correlated positively with LH, whereas leptin and @entity3 were correlated negatively with LH. Bivariate synchrony of LH with insulin was decreased. Short-term caloric restriction paradoxically increased LH secretion by 1.5-fold and pattern irregularity, and reduced interpulse variability. @entity3 secretion and fasting concentrations of @entity2 and @entity4 levels remained unchanged. Correlations between LH and insulin, leptin, and calculated free @entity3 decreased. This study demonstrates marked alterations in the control of LH secretion in @entity6 in the fed and calorie-restricted states. The ensemble results point to abnormal feedback control of not only the @entity5 -gonadotrope complex, but also LH's relationships with leptin, insulin, and @entity3 .

title: Altered multihormone synchrony in @entity1 @entity0 with XXXX .

answer: @entity6


abstract: Luteinizing hormone (LH) concentrations and pulsatility are increased in @entity1 @entity0 with @entity6 ( @entity6 ). In addition, @entity0 have @entity6 and insulin resistance. The mechanisms involved in aberrant hormone regulation in @entity6 are still unclear. We investigated 15 @entity6 @entity0 with a body mass index between 30 and 54 kg/m(2) and 9 healthy @entity1 controls (body mass index, 31-60 kg/m(2)) with regular menstrual cycles. Subjects underwent 24-hour blood sampling at 10-minute intervals for later measurements of LH, leptin, @entity3 , and insulin concentrations. Data were analyzed with a new deconvolution program, approximate entropy (and bivariate approximate entropy), and a cross-correlation network. @entity0 had increased LH pulse frequency and more than 2-fold greater daily LH secretion, with diminished pattern regularity. @entity3 secretion was increased 2-fold, but pattern regularity was similar to that in controls. In the network construct, insulin was correlated positively with LH, whereas leptin and @entity3 were correlated negatively with LH. Bivariate synchrony of LH with insulin was decreased. Short-term caloric restriction paradoxically increased LH secretion by 1.5-fold and pattern irregularity, and reduced interpulse variability. @entity3 secretion and fasting concentrations of @entity2 and @entity4 levels remained unchanged. Correlations between LH and insulin, leptin, and calculated free @entity3 decreased. This study demonstrates marked alterations in the control of LH secretion in @entity6 in the fed and calorie-restricted states. The ensemble results point to abnormal feedback control of not only the @entity5 -gonadotrope complex, but also LH's relationships with leptin, insulin, and @entity3 .

title: Altered multihormone synchrony in XXXX @entity0 with @entity6 .

answer: @entity1


abstract: Luteinizing hormone (LH) concentrations and pulsatility are increased in @entity1 @entity0 with @entity6 ( @entity6 ). In addition, @entity0 have @entity6 and insulin resistance. The mechanisms involved in aberrant hormone regulation in @entity6 are still unclear. We investigated 15 @entity6 @entity0 with a body mass index between 30 and 54 kg/m(2) and 9 healthy @entity1 controls (body mass index, 31-60 kg/m(2)) with regular menstrual cycles. Subjects underwent 24-hour blood sampling at 10-minute intervals for later measurements of LH, leptin, @entity3 , and insulin concentrations. Data were analyzed with a new deconvolution program, approximate entropy (and bivariate approximate entropy), and a cross-correlation network. @entity0 had increased LH pulse frequency and more than 2-fold greater daily LH secretion, with diminished pattern regularity. @entity3 secretion was increased 2-fold, but pattern regularity was similar to that in controls. In the network construct, insulin was correlated positively with LH, whereas leptin and @entity3 were correlated negatively with LH. Bivariate synchrony of LH with insulin was decreased. Short-term caloric restriction paradoxically increased LH secretion by 1.5-fold and pattern irregularity, and reduced interpulse variability. @entity3 secretion and fasting concentrations of @entity2 and @entity4 levels remained unchanged. Correlations between LH and insulin, leptin, and calculated free @entity3 decreased. This study demonstrates marked alterations in the control of LH secretion in @entity6 in the fed and calorie-restricted states. The ensemble results point to abnormal feedback control of not only the @entity5 -gonadotrope complex, but also LH's relationships with leptin, insulin, and @entity3 .

title: Altered multihormone synchrony in @entity1 XXXX with @entity6 .

answer: @entity0


abstract: @entity2 ( @entity2 ) is a locally aggressive cutaneous @entity1 that exhibits a marked tendency for recurrence after local excision. This case series aims to study the clinical, histological and immunohistochemical features of @entity2 in Asians. Ten @entity0 with @entity2 diagnosed between 1992 and 2001 were reviewed. There were more @entity0 than @entity0 in a ratio of 4:1. There were six Chinese, two Malays, one Indian and one Eurasian. The mean age was 38 years. The duration of each lesion before excision varied from 6 months to 27 years. Fifty per cent of @entity1 occurred on the trunk. On histology, all the lesions were dermal-centred spindle cell @entity1 , extending to the subcutis, and exhibited the characteristic storiform pattern. One @entity1 also demonstrated @entity2 . Two @entity1 were of the rare pigmented variant ( @entity1 ). Immunohistochemistry with @entity3 was positive in all cases, except the @entity1 , which was negative for @entity3 . For comparison, six cases of deep-penetrating @entity4 were stained for @entity3 and all showed an absence of @entity3 expression. Wide excision of the @entity1 was performed in all cases of @entity2 . There was no recurrence after mean follow up of 6 years (range 2.25-9.5 years).

title: XXXX : a clinicopathological analysis of 10 cases in Asians.

answer: @entity2


abstract: BACKGROUND: Hospital registries are an important component of @entity1 screening efforts of individuals and communities. This paper describes the structure and goals of a @entity8 Family Registry at a metropolitan hospital. @entity0 characteristics, differences between @entity6 among probands, subjective distress in relation to perception of @entity2 , and quality of life were examined. METHODS: @entity0 were @entity0 with @entity2 ( @entity2 ), @entity9 ( @entity9 ), @entity2 ( @entity2 ) and inflammatory bowel disease @entity4 ( @entity4 ) and @entity3 representing a range of @entity8 . A total of 630 probands were recruited into the registry and administered a questionnaire. RESULTS: Of the 630 probands, 198 (31.4%) were diagnosed with @entity2 , 36 (5.3%) with @entity9 or @entity2 and 272 (43.2%) with @entity4 or @entity3 . The majority of all three groups had some level of college education, was white, and reported a household income greater then  70,000. The Impact of Event Scale score was found to be of notable significance when categorized by relation to proband (p<0.01) and proband diagnoses (p  <= 0.000). On the quality of life item, the largest difference was between @entity9 or @entity2 and @entity4 or @entity3 without @entity2 . CONCLUSION: Subjective distress scores were higher for @entity2 probands in comparison to probands with other @entity2 . Quality of life was relatively high for all probands. @entity7 should be explored in more depth and more frequently to screen for any concomitant @entity5 disorders like post-traumatic symptoms that have been linked to a @entity1 diagnosis.

title: Descriptive characteristics of a XXXX family registry at an urban hospital.

answer: @entity8


abstract: A @entity4 analogue, @entity5 was administered to control the postpartum @entity3 , immediately after the baby was born, to 74 healthy @entity0 , who had normal pregnancy and delivery. Divided into three groups they received 50 or 100 micrograms intravenously, or 200 micrograms intramuscularly. The results were compared with those of a group of 54 @entity0 , which received 0.2 mg @entity6 i.m. and 5 IU @entity2 i.v. respectively. The @entity1 was measured during the third stage of labour and during two hours thereafter. The pilot dose of 50 micrograms was not effective enough. The @entity1 in the group of 100 micrograms i.v. was 386 +/- 175 ml, in the group of 200 micrograms i.m. 325 +/- 197 ml, and in the @entity6 - @entity2 group 302 +/- 202 ml. @entity5 200 micrograms i.m. seems to be effective treatment to control the postpartum @entity3 . Only four @entity0 had mild side-effects after @entity5 administration.

title: @entity5 in the control of postpartum XXXX .

answer: @entity3


abstract: A @entity4 analogue, @entity5 was administered to control the postpartum @entity3 , immediately after the baby was born, to 74 healthy @entity0 , who had normal pregnancy and delivery. Divided into three groups they received 50 or 100 micrograms intravenously, or 200 micrograms intramuscularly. The results were compared with those of a group of 54 @entity0 , which received 0.2 mg @entity6 i.m. and 5 IU @entity2 i.v. respectively. The @entity1 was measured during the third stage of labour and during two hours thereafter. The pilot dose of 50 micrograms was not effective enough. The @entity1 in the group of 100 micrograms i.v. was 386 +/- 175 ml, in the group of 200 micrograms i.m. 325 +/- 197 ml, and in the @entity6 - @entity2 group 302 +/- 202 ml. @entity5 200 micrograms i.m. seems to be effective treatment to control the postpartum @entity3 . Only four @entity0 had mild side-effects after @entity5 administration.

title: XXXX in the control of postpartum @entity3 .

answer: @entity5


abstract: BACKGROUND: @entity3 ( @entity3 ) is an important prevention initiative in reducing @entity2 /AIDS transmission. Despite current global prevention efforts, many low- and middle-income countries continue reporting low @entity3 levels. Little is known about the association of within- and between-country socioeconomic inequalities and @entity3 . Based on the 'inverse equity hypothesis,' this study examines the degree to which low socioeconomic groups in developing countries are disadvantaged in @entity3 . METHODS: Using recently released data from the 2002 to 2003 @entity1 ( @entity1 ) for 106 705 individuals in 49 countries, this study used multilevel logistic regression to examine the association of individual- and national-level factors with @entity3 , and whether national economic development moderated the association between individual income and @entity3 . Individual income was based on country-specific income quintiles. National economic development was based on national gross domestic product per capita ( @entity4 /c). Effect modification was evaluated with the likelihood ratio test (G(2)). Individuals eligible for the @entity3 question of the @entity1 were adults between the ages of 18-49 years; @entity0 who had given birth in the last 2 years were excluded from this question. RESULTS: @entity3 was more likely among higher income quintiles and in countries with higher @entity4 /c. @entity4 /c moderated the association between individual income and @entity3 whereby relative income differences in @entity3 were greater in countries with lower @entity4 /c (G(2)= 9.21; P= 0.002). Individual socio-demographic characteristics were also associated with the likelihood of a @entity0 having @entity3 . CONCLUSIONS: Relative socioeconomic inequalities in @entity3 coverage appear to decline when higher SES groups reach a certain level of coverage. These findings suggest that changes to international @entity3 programs may be necessary to moderate the relative @entity3 differences between high- and low-income individuals in lower @entity4 /c nations.

title: Global income-related inequalities in XXXX testing.

answer: @entity2


abstract: Budget studies have shown that internal cycling may contribute a large proportion of the annual nutrient supply required to support new growth in trees. Use of budgets to quantify internal cycling only quantifies the net transfer of nutrients within the plant. Differential partitioning of remobilized nutrients and current nutrient uptake could lead to errors in the interpretation of results from these studies. We have quantified the dynamic relationships among tree growth, nutrient uptake and internal cycling by labeling the current uptake of N in trees that received contrasting amounts of nutrient. Two-year-old seedlings of @entity1 ( @entity1 (Bong.) Carr.) were grown in sand culture in a greenhouse for one year. The trees received nutrients in a balanced solution at either a high (high-RAR) or a low (low-RAR) relative addition rate throughout the experiment. Current N uptake was labeled with @entity0 from April 13 to July 25. Thereafter, trees were re-potted in clean sand and unlabeled N applied until November 13. Overall growth was sustained for approximately 10 weeks before treatment effects were observed. Initially, no differences in the partition of growth or remobilized N occurred, although partition of current uptake favored the roots of plants in the low-RAR treatment. After 6 weeks, the partition of both growth and remobilized N altered in favor of roots of plants in the low-RAR treatment. Nutrient supply had no effect on the amount or rate of N remobilization. No evidence was found to suggest that N taken up in the current season and partitioned to preexisting shoots or roots is remobilized late in the season to support growth of new shoots. However, some trees in the high-RAR treatment exhibited a second flush of growth later in the season that was partially sustained by remobilization of @entity0 from current shoots formed earlier in the season. Use of @entity0 demonstrated differential partitioning of current uptake and remobilized N. The results highlight the limitations of simple budget studies for quantifying internal cycling.

title: Relationships between nutrient supply, nitrogen partitioning and growth in young XXXX ( @entity1 ).

answer: @entity1


abstract: Budget studies have shown that internal cycling may contribute a large proportion of the annual nutrient supply required to support new growth in trees. Use of budgets to quantify internal cycling only quantifies the net transfer of nutrients within the plant. Differential partitioning of remobilized nutrients and current nutrient uptake could lead to errors in the interpretation of results from these studies. We have quantified the dynamic relationships among tree growth, nutrient uptake and internal cycling by labeling the current uptake of N in trees that received contrasting amounts of nutrient. Two-year-old seedlings of @entity1 ( @entity1 (Bong.) Carr.) were grown in sand culture in a greenhouse for one year. The trees received nutrients in a balanced solution at either a high (high-RAR) or a low (low-RAR) relative addition rate throughout the experiment. Current N uptake was labeled with @entity0 from April 13 to July 25. Thereafter, trees were re-potted in clean sand and unlabeled N applied until November 13. Overall growth was sustained for approximately 10 weeks before treatment effects were observed. Initially, no differences in the partition of growth or remobilized N occurred, although partition of current uptake favored the roots of plants in the low-RAR treatment. After 6 weeks, the partition of both growth and remobilized N altered in favor of roots of plants in the low-RAR treatment. Nutrient supply had no effect on the amount or rate of N remobilization. No evidence was found to suggest that N taken up in the current season and partitioned to preexisting shoots or roots is remobilized late in the season to support growth of new shoots. However, some trees in the high-RAR treatment exhibited a second flush of growth later in the season that was partially sustained by remobilization of @entity0 from current shoots formed earlier in the season. Use of @entity0 demonstrated differential partitioning of current uptake and remobilized N. The results highlight the limitations of simple budget studies for quantifying internal cycling.

title: Relationships between nutrient supply, nitrogen partitioning and growth in young @entity1 ( XXXX ).

answer: @entity1


abstract: During different phases of the annual growth cycle, xylem sap was collected from trunk segments of adult beech (Fagus sylvatica L.) trees by the water displacement technique. Irrespective of the height of the trunk, both @entity1 and reduced @entity2 compounds were detected in the xylem sap throughout the year. @entity1 was the predominant @entity2 compound in all samples analyzed. Its concentration in the xylem sap varied between 10 and 350 micro mol l(-1), with highest concentrations in April, shortly before bud break. In contrast to other tree species, @entity0 and not @entity4 was the predominant @entity3 transported in the xylem sap of beech trees. The @entity0 concentration ranged between 0.1 and 1 micro mol l(-1). As observed for @entity1 , maximum @entity0 concentrations were found in April. Apparently, both @entity1 and @entity0 transport contribute to the @entity2 supply of the developing leaves. Seasonal changes in the axial distribution of @entity0 and @entity1 differed, indicating differences in the source-sink relations of these @entity2 compounds. High, but uniform, xylem sap @entity1 concentrations in April may originate from balanced @entity1 uptake by the roots, whereas high @entity0 concentrations in April, increasing with increasing height of the trunk, may originate in part from protein breakdown in the trunk. Reversal of the axial distribution of xylem sap @entity0 in late summer-early fall to higher concentrations in the lower part of the trunk than in the upper part of the trunk suggests that the upper part of the trunk becomes a sink for @entity0 as a result of the synthesis of storage proteins at this time of the year.

title: Xylem sap composition of beech (Fagus sylvatica L.) trees: seasonal changes in the axial distribution of XXXX compounds.

answer: @entity2


abstract: There is considerable evidence that alterations in striatal medium-sized spiny neurons (MSSNs) giving rise to the direct ( @entity9 -expressing) and indirect ( @entity8 -expressing) pathways differentially contribute to the phenotype of @entity4 ( @entity4 ). To determine how each subpopulation of MSSN is functionally affected, we examined spontaneous excitatory postsynaptic currents (sEPSCs) and @entity2 (DA) modulation in two @entity4 @entity0 models, the YAC128 and the BACHD (a @entity6 ). These @entity0 also expressed enhanced green fluorescent protein (EGFP) under the control of the promoter for either DA D1 or D2 receptors to identify neurons. In early symptomatic YAC128 and BACHD @entity0 , @entity5 transmission was increased in both D1 and D2 MSSNs, but in different ways. D1 cells displayed increased sEPSC frequencies and decreased paired-pulse ratios (PPRs) while D2 cells displayed larger evoked @entity5 currents but no change in sEPSC frequencies or PPRs. @entity9 modulation of sEPSCs was absent in D1-YAC128 cells at the early symptomatic stage but was restored by treating the slices with @entity3 . In contrast, in fully symptomatic YAC128 @entity0 , @entity5 transmission was decreased specifically in D1 cells, and @entity9 modulation was normal in D1-YAC128 cells. Behaviorally, early symptomatic @entity0 showed increased stereotypies that were decreased by @entity3 treatment. Together, these studies support differential imbalances in @entity5 and DA transmission in direct and indirect pathway MSSNs. @entity1 at an early stage could be explained by increased @entity5 activity and DA tone in direct pathway neurons, whereas @entity7 at later stages could result from reduced input onto these neurons.

title: Differential electrophysiological changes in striatal output neurons in XXXX .

answer: @entity4


abstract: The nonpoliovirus enteroviruses commonly infect newborns, with consequences ranging from @entity12 and benign illness, to severe, life-threatening disease. Frequently occurring symptoms include @entity4 , @entity3 , lethargy, @entity6 , and @entity10 . Although most illnesses are mild, severe disease develops in a subset of newborns infected in the first 2 weeks of life. Severe disease may consist of @entity5 , @entity13 , @entity11 , @entity1 , @entity2 , and/or @entity8 . Substantial mortality rates have been reported, and long-term sequelae may occur among survivors. Risk factors and clinical features associated with severe disease include absence of neutralizing antibody to the infecting serotype, maternal illness prior to or at delivery, prematurity, illness onset within the first few days of life, multiorgan disease, severe @entity2 , positive serum viral culture, and specific infecting serotype (e.g. group B coxsackieviruses and echovirus 11). Whereas the mainstay of diagnosis has traditionally been viral isolation in tissue culture, the polymerase chain reaction has been demonstrated to be more sensitive than culture, highly specific, and rapid. Immunoglobulin has been used as a therapeutic agent for neonates with enterovirus disease; however, clinical efficacy has not been proven. Specific antiviral therapy for enteroviruses is in development. Pleconaril is an investigational agent that inhibits viral attachment to host cell receptors and uncoating of viral nucleic acid. It has broad and potent anti-enterovirus activity, excellent oral bioavailability, and is well tolerated. Some clinical trials have demonstrated benefit in @entity0 and adults with @entity7 , and in adults with @entity9 caused by picornaviruses (rhinoviruses or enteroviruses). Data summarizing compassionate use for severe @entity14 (including @entity5 ) also suggest possible benefit. Limited pharmacokinetic data are available in @entity0 and neonates. A multicenter, placebo-controlled, randomized trial of @entity15 in neonates with severe @entity2 , @entity8 , and/or @entity11 is currently being conducted.

title: Presentation, diagnosis, and management of XXXX in neonates.

answer: @entity14


abstract: PURPOSE: Mutations in the @entity8 gene cause recessive, severe @entity5 ( @entity5 ). @entity8 encodes the b subunit of the rod-specific phosphodiesterase (bPDE), which, when absent, results in toxic levels of intracellular @entity1 and photoreceptor cell death. @entity1 blockers, such as @entity6 , as well as light restriction, slow @entity2 in animal models of @entity3 . The goal of the study was to evaluate the efficacy of @entity4 /5- or @entity4 /8-mediated gene replacement in combination with @entity6 and/or with light restriction in the @entity7 @entity0 bearing homozygous @entity7 mutations. METHODS: AAV vectors encoding either bPDE or EGFP were subretinally administered at postnatal day (P)2. @entity6 was administered from P7 to P28. For light restriction, pregnant @entity7 @entity0 were kept in a dark environment until their pups were 28 days old. All functional and histologic analyses were performed at P35. RESULTS: Significant morphologic photoreceptor protection was observed after subretinal administration of AAV vectors encoding EGFP. This protection further increased after administration of @entity4 /8 or -2/5 encoding for bPDE and was not associated with significant functional improvement. Photoreceptor protection was higher after @entity4 /8- than after @entity4 /5-mediated delivery and was not significantly augmented by additional drug therapy and/or light restriction. The protective effect was lost after P35. CONCLUSIONS: In conclusion, more efficient gene transfer tools than those used in this study, as well as a better understanding of the disease pathogenesis, should be explored to increase the effect of gene replacement and to design gene-based strategies that block the apoptotic pathways activated by @entity3 .

title: AAV-mediated gene replacement, either alone or in combination with physical and pharmacological agents, results in partial and transient protection from XXXX associated with @entity3 .

answer: @entity2