abstract: Updated guidelines published recently by the National @entity2 Education Program place greater emphasis on @entity8 , characterized by low high-density lipoprotein (HDL) @entity2 ; elevated @entity7 ; and small, dense, low-density lipoprotein (LDL) particles, as well as the drugs that can alter the condition. Both low HDL @entity2 and elevated @entity7 are independent risk factors for @entity5 . Low-density lipoprotein particles can be divided into subclasses with differing atherogenicity. Phenotype A is characterized by large buoyant LDL particles, and phenotype B by small, dense particles associated with increased atherogenicity. The frequency of phenotype B in @entity0 increases as @entity4 levels increase and HDL @entity2 levels decrease. Fibrates and @entity6 have been shown to improve @entity8 in clinical trials. @entity6 effectively lowers @entity7 , raises HDL @entity2 , and shifts LDL particles to a less atherogenic phenotype (phenotype A). The various @entity6 formulations available differ in terms of safety and efficacy. When administered alone or in combination with other lipid-modifying agents, @entity6 prevents progression and promotes regression of @entity3 and reduces coronary risk. Combination therapy is also an effective option for improving @entity1 . In studies, a once-daily, single-tablet combination of @entity6 extended-release/lovastatin showed additive LDL @entity2 lowering and was more effective than would be anticipated from doubling the component @entity9 dose. Combination products provide a viable strategy for treating the full spectrum of lipid abnormalities seen in some @entity0 , including those with @entity8 , and will be increasingly used in the treatment of @entity8 . Other combination products are currently undergoing clinical testing.

title: @entity6 -based therapy for XXXX : past evidence and future advances.

answer: @entity8


abstract: Updated guidelines published recently by the National @entity2 Education Program place greater emphasis on @entity8 , characterized by low high-density lipoprotein (HDL) @entity2 ; elevated @entity7 ; and small, dense, low-density lipoprotein (LDL) particles, as well as the drugs that can alter the condition. Both low HDL @entity2 and elevated @entity7 are independent risk factors for @entity5 . Low-density lipoprotein particles can be divided into subclasses with differing atherogenicity. Phenotype A is characterized by large buoyant LDL particles, and phenotype B by small, dense particles associated with increased atherogenicity. The frequency of phenotype B in @entity0 increases as @entity4 levels increase and HDL @entity2 levels decrease. Fibrates and @entity6 have been shown to improve @entity8 in clinical trials. @entity6 effectively lowers @entity7 , raises HDL @entity2 , and shifts LDL particles to a less atherogenic phenotype (phenotype A). The various @entity6 formulations available differ in terms of safety and efficacy. When administered alone or in combination with other lipid-modifying agents, @entity6 prevents progression and promotes regression of @entity3 and reduces coronary risk. Combination therapy is also an effective option for improving @entity1 . In studies, a once-daily, single-tablet combination of @entity6 extended-release/lovastatin showed additive LDL @entity2 lowering and was more effective than would be anticipated from doubling the component @entity9 dose. Combination products provide a viable strategy for treating the full spectrum of lipid abnormalities seen in some @entity0 , including those with @entity8 , and will be increasingly used in the treatment of @entity8 . Other combination products are currently undergoing clinical testing.

title: XXXX -based therapy for @entity8 : past evidence and future advances.

answer: @entity6


abstract: INTRODUCTION: @entity2 of the face, especially @entity10 and @entity11 are indications for surgical interventions after failed medical therapy. In contrast to other forms of @entity3 or atypical @entity8 , where surgical measures are considered to be contraindicated, percutaneous procedures or @entity12 are able to produce immediate and @entity8 relief. Careful preoperative evaluation is essential to confirm the clinical diagnosis and to rule out other causes as @entity4 or @entity1 afflicting the cranial nerves. The following study will summarize the common surgical techniques and their role considering a mechanism-based therapy as well as document long-term results of these measures. METHODS: Between 1977 and 1997 316 thermo-controlled radiofrequency trigeminal rhizotomies (TK) and 379 @entity12 ( @entity12 ) were performed in our hospital to treat @entity10 ; additional 6 MVDs for @entity11 and one @entity12 of the intermediate facial nerve were carried out. Questionnaires were sent out to all @entity0 still living in 1981, 1982, 1992 and 1998. For all other @entity0 , interviews with relatives or the general practitioners were conducted. A retrospective analysis of @entity9 relief was performed using Kaplan-Meier curves at the latest follow-up. Additionally 80 @entity0 underwent careful quantitative sensory testing with Von-Frey-hairs. RESULTS: 225 @entity0 who underwent @entity12 and 206 with radiofrequency trigeminal rhizotomies were further analyzed. There was a 50% risk for @entity8 recurrence two years after radiofrequency rhizotomy. On the other hand 64% of @entity0 who underwent @entity12 remained painfree 20 years postoperatively. @entity0 with @entity12 without @entity5 were painfree significantly longer than @entity0 with @entity6 . DISCUSSION: Etiology and pathogenesis of @entity13 are far from understood despite several hypotheses. Based on current models there is no explanation for the immediate @entity8 relief especially after @entity12 . Some authors even discuss surgical @entity7 as the only cause for @entity9 relief.

title: [Neurosurgical therapy of XXXX ].

answer: @entity13


abstract: Nineteen adult @entity0 with poor-risk @entity6 received @entity5 ( @entity5 ) hematopoietic progenitor cell (HPC) transplant from partially mismatched related donors (PMRD). The preparative regimen (FITFA) included fractionated @entity2 , thiotepa, @entity9 , and @entity7 (n = 3) or @entity1 (n = 16) anti-thymocyte anti-sera (ATG). GVHD prophylaxis consisted of @entity5 by positive/negative selection using the Isolex 300i system and pre-transplant ATG with no post-transplant immunosuppression. The mean number (+/-s.d.) of transplanted @entity8 (+) and CD3(+) cells were 8.9 x 10(6)/kg +/-4.3 (range 2.6-19.3) and 1.4 x 10(4)/kg +/-1.2 (range 0.3-4.6) respectively. Seventeen @entity0 evaluable for neutrophil engraftment achieved an ANC >0.5 x 10(9)/l at a median of 12 days (range 9-27), with evidence of full donor chimerism. Thirteen @entity0 died of the following causes: relapse (n = 6), @entity3 (n = 5), @entity4 (n = 1), and unknown causes (n = 1) None of the recipients of @entity1 ATG required therapy for acute or chronic GVHD. Five @entity0 are alive and disease-free at a median time of 303 days post transplant (range 100-660). The FITFA preparative regimen using fractionated @entity2 is well tolerated and is sufficiently immunosuppressive to allow rapid and stable donor origin hematopoietic engraftment without 'mega' doses of @entity8 (+) cells. Combination of stringent ex vivo @entity5 and pre-transplant ATG is effective GVHD prophylaxis.

title: Rapid hematopoietic engraftment following fractionated XXXX conditioning and transplantation with @entity8 (+) enriched hematopoietic progenitor cells from partially mismatched related donors.

answer: @entity2


abstract: Nineteen adult @entity0 with poor-risk @entity6 received @entity5 ( @entity5 ) hematopoietic progenitor cell (HPC) transplant from partially mismatched related donors (PMRD). The preparative regimen (FITFA) included fractionated @entity2 , thiotepa, @entity9 , and @entity7 (n = 3) or @entity1 (n = 16) anti-thymocyte anti-sera (ATG). GVHD prophylaxis consisted of @entity5 by positive/negative selection using the Isolex 300i system and pre-transplant ATG with no post-transplant immunosuppression. The mean number (+/-s.d.) of transplanted @entity8 (+) and CD3(+) cells were 8.9 x 10(6)/kg +/-4.3 (range 2.6-19.3) and 1.4 x 10(4)/kg +/-1.2 (range 0.3-4.6) respectively. Seventeen @entity0 evaluable for neutrophil engraftment achieved an ANC >0.5 x 10(9)/l at a median of 12 days (range 9-27), with evidence of full donor chimerism. Thirteen @entity0 died of the following causes: relapse (n = 6), @entity3 (n = 5), @entity4 (n = 1), and unknown causes (n = 1) None of the recipients of @entity1 ATG required therapy for acute or chronic GVHD. Five @entity0 are alive and disease-free at a median time of 303 days post transplant (range 100-660). The FITFA preparative regimen using fractionated @entity2 is well tolerated and is sufficiently immunosuppressive to allow rapid and stable donor origin hematopoietic engraftment without 'mega' doses of @entity8 (+) cells. Combination of stringent ex vivo @entity5 and pre-transplant ATG is effective GVHD prophylaxis.

title: Rapid hematopoietic engraftment following fractionated @entity2 conditioning and transplantation with XXXX (+) enriched hematopoietic progenitor cells from partially mismatched related donors.

answer: @entity8


abstract: OBJECTIVE: To evaluate racial differences in limb loss caused by @entity4 in a diverse, statewide population. DESIGN: Retrospective analysis of a cohort of dysvascular amputees. SETTING: Maryland State Hospital Discharge Data from 1986 to 1997. @entity0 : @entity0 with a procedure code for lower-limb amputation (ICD9-CM code 84.11-.19) were identified. @entity0 with limb loss because of @entity2 , @entity1 , or @entity3 were excluded. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Incidence rates standardized for age, gender, and race; and time trends. RESULTS: There were 27,149 discharges with dysvascular amputations, yielding an average annual rate of 44.3 per 100,000 @entity0 . Incidence rates for dysvascular amputations increased from 41.4 per 100,000 in 1986 to 47.2 per 100,000 in 1997. For all levels of amputation, annual incidence rates among African Americans were considerably higher than those of other @entity0 . African Americans were 2 to 4 times more likely to lose a lower limb than white @entity0 of similar age and gender. CONCLUSIONS: Rising rates of lower-limb amputations in the general population combined with disproportionately higher rates among African Americans are concerning and warrant further investigation into their underlying causes and consequences.

title: Racial differences in the incidence of limb loss secondary to XXXX : a population-based study.

answer: @entity4


abstract: BACKGROUND: @entity6 ( @entity6 ) has been recognized as a cause of @entity4 . Its main risk factor is @entity1 . AIM: To describe the clinical and liver pathological findings in a group of @entity0 who underwent surgery as @entity1 treatment. @entity0 AND METHODS: Sixty eight @entity0 with severe or morbid @entity1 were subjected to surgery as @entity1 treatment. Each @entity0 was evaluated with a complete clinical and laboratory medical assessment. A wedge of liver was excised during surgery. Liver biopsies were analyzed without knowledge of clinical and laboratory findings. The presence of @entity5 , @entity2 (portal or lobular), @entity3 and @entity3 were recorded in the pathological analysis. Age and body mass index (BMI) were correlated with pathological data. Significance was set at a p value of less than 0.05. RESULTS: Ninety one percent of @entity0 had @entity5 , 45% @entity2 and 47% @entity3 . One @entity0 had @entity3 (1.4%). There was a statistically significant association between BMI and moderate or severe @entity5 (p < 0.03). There was also an association between BMI and portal (p = 0.017) and @entity2 (p = 0.034). A BMI over 40 kg/m2 (morbid @entity1 ) was significantly associated with the presence of @entity3 (p = 0.032). Moreover, the presence of moderate or severe @entity5 was a risk factor for the development of @entity7 (p = 0.026). CONCLUSIONS: Obesity is a major and independent risk factor for @entity5 and @entity3 . The degree of @entity5 in the liver biopsy, is a risk factor for the development of @entity3 .

title: [Obesity: risk factor for XXXX and @entity7 ].

answer: @entity5


abstract: BACKGROUND: @entity6 ( @entity6 ) has been recognized as a cause of @entity4 . Its main risk factor is @entity1 . AIM: To describe the clinical and liver pathological findings in a group of @entity0 who underwent surgery as @entity1 treatment. @entity0 AND METHODS: Sixty eight @entity0 with severe or morbid @entity1 were subjected to surgery as @entity1 treatment. Each @entity0 was evaluated with a complete clinical and laboratory medical assessment. A wedge of liver was excised during surgery. Liver biopsies were analyzed without knowledge of clinical and laboratory findings. The presence of @entity5 , @entity2 (portal or lobular), @entity3 and @entity3 were recorded in the pathological analysis. Age and body mass index (BMI) were correlated with pathological data. Significance was set at a p value of less than 0.05. RESULTS: Ninety one percent of @entity0 had @entity5 , 45% @entity2 and 47% @entity3 . One @entity0 had @entity3 (1.4%). There was a statistically significant association between BMI and moderate or severe @entity5 (p < 0.03). There was also an association between BMI and portal (p = 0.017) and @entity2 (p = 0.034). A BMI over 40 kg/m2 (morbid @entity1 ) was significantly associated with the presence of @entity3 (p = 0.032). Moreover, the presence of moderate or severe @entity5 was a risk factor for the development of @entity7 (p = 0.026). CONCLUSIONS: Obesity is a major and independent risk factor for @entity5 and @entity3 . The degree of @entity5 in the liver biopsy, is a risk factor for the development of @entity3 .

title: [Obesity: risk factor for @entity5 and XXXX ].

answer: @entity7


abstract: Severe chronic @entity3 is defined as less than two bowel movements per week, hard stools, non productive urgency and the need of digital maneuvers in more than 25% of bowel evacuations. The best studied causes of chronic severe @entity3 are slow bowel transit @entity5 . However, there are mixed forms that cross link with @entity4 . The main diagnostic tests are anorrectal manometry, bowel evacuation, X-ray studies and anorrectal sphincteromyomectomy, that can be therapeutic. Five percent of @entity0 are surgical candidates. In cases of slow bowel movement, total colectomy with @entity1 has satisfactory results in 80 to 90% of @entity0 . Some @entity0 with pelvic floor dysfunction have an occult rectal prolapse, rectocele or sigmoidocele and obtain benefits with the correction of these conditions. The remaining @entity0 require a training of bowel evacuation, known as biofeedback. We have performed a total colectomy in 10 @entity0 with @entity2 with good functional results in 80%. After 56 months of follow-up, a mean 2.6 bowel movements per day is reported by the @entity0 . Four @entity0 were also operated due to a solitary rectal ulcer and two @entity0 due to a sigmoidocele, with satisfactory results.

title: [Severe chronic XXXX . Is it a problem of surgery?].

answer: @entity3


abstract: PURPOSE: To analyze the effect of intensified topical @entity3 therapy after Descemet membrane endothelial keratoplasty combined with @entity2 surgery (triple-DMEK) on the incidence of @entity4 ( @entity4 ). DESIGN: Single-center comparative clinical study with historical controls. METHODS: Setting: Department of Ophthalmology, University of Cologne, Germany, tertiary hospital, performing 500 corneal transplant surgeries per year. @entity0 : Total of 131 @entity0 (150 eyes) undergoing triple-DMEK surgery. Inclusion Criterion: Triple-DMEK surgery. EXCLUSION CRITERIA: Prior retinal surgery, history of prior @entity4 . INTERVENTIONS: @entity5 eye drops 1% 5 times daily for the first week after surgery. After an internal change of therapy regimen: @entity5 eye drops 1% hourly for the first postoperative week. We compared 75 consecutive eyes before with 75 consecutive eyes after the change of therapy regimen. @entity0 received macular spectral-domain optical coherence tomography (SD OCT) preoperatively, as well as 6  weeks and 3 and 6  months post surgery. MAIN OUTCOME MEASURE: Development of @entity4 detected by macular SD OCT during 6  months postoperatively. RESULTS: Both groups were comparable regarding baseline age, sex, central corneal thickness, rebubbling rate, and visual acuity. With topical @entity3 therapy 5 times per day during the first postoperative week, we observed 9 cases of subsequent @entity4 (12%). With hourly topical @entity3 therapy none of the @entity0 developed @entity4 subsequently (P  = .003). Apart from the topical @entity1 during the first week, medical treatment was identical in both groups. CONCLUSIONS: Early intensified postoperative topical  @entity3 therapy constitutes an effective prophylactic treatment to reduce incidence of @entity4 after triple-DMEK surgery.

title: Intensified Topical XXXX as Prophylaxis for Macular Edema After Posterior Lamellar Keratoplasty Combined With Cataract Surgery.

answer: @entity1


abstract: BACKGROUND: Ischemic @entity1 are usually found above the lateral, and @entity3 at the medial malleoli. Leg @entity1 occur in at least 25% of @entity4 ( @entity9 ) @entity0 in clinic populations, usually in the malleolar region. The function of the large leg veins in most @entity9 @entity0 is unimpaired. @entity0 AND METHODS: We determined leg @entity1 location in 41 @entity4 (SS), and 4 sickle-beta 0 thalassemic @entity0 with longstanding chronic and/or recurrent leg ulceration, and reviewed published reports of @entity6 in @entity7 . RESULTS: Of the 57 legs of the 45 @entity9 @entity0 with only 1 @entity1 , 42 (74%) were medial and 15 lateral. The difference was significant (p < 0.001). Of @entity0 with only a single @entity1 , 22 were medial and 4 lateral. Of 15 reported @entity0 with @entity6 related to @entity8 or @entity2 , 20/24 (83%) @entity1 were medial. CONCLUSIONS: The medial malleoli are the most common site of leg ulceration in @entity9 and in other chronic @entity5 . This suggests that @entity3 may play a role in the leg ulceration associated with chronic @entity5 .

title: Predilection of XXXX for the medial malleolus.

answer: @entity5


abstract: AIMS: @entity5 ( @entity5 ) is a @entity1 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity2 concentration is reduced in specific areas of the @entity1 microenvironment, which leads to intratumoral @entity4 . Crosstalk between @entity3 , @entity7 , @entity6 and @entity8 under @entity4 conditions has been implicated in invadopodia formation, @entity1 invasiveness and @entity0 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity5 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity5 , 8 cases of @entity1 ( @entity1 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity3 , anti- @entity7 , anti- @entity6 and anti- @entity8 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity5 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity5 exhibited increased presence of proteins associated with @entity1 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity1 . This article is protected by copyright. All rights reserved.

title: Role of @entity4 -related proteins in invasion of @entity5 cells: crosstalk between @entity3 , @entity6 , XXXX , and @entity8 .

answer: @entity7


abstract: AIMS: @entity5 ( @entity5 ) is a @entity1 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity2 concentration is reduced in specific areas of the @entity1 microenvironment, which leads to intratumoral @entity4 . Crosstalk between @entity3 , @entity7 , @entity6 and @entity8 under @entity4 conditions has been implicated in invadopodia formation, @entity1 invasiveness and @entity0 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity5 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity5 , 8 cases of @entity1 ( @entity1 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity3 , anti- @entity7 , anti- @entity6 and anti- @entity8 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity5 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity5 exhibited increased presence of proteins associated with @entity1 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity1 . This article is protected by copyright. All rights reserved.

title: Role of @entity4 -related proteins in invasion of @entity5 cells: crosstalk between XXXX , @entity6 , @entity7 , and @entity8 .

answer: @entity3


abstract: AIMS: @entity5 ( @entity5 ) is a @entity1 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity2 concentration is reduced in specific areas of the @entity1 microenvironment, which leads to intratumoral @entity4 . Crosstalk between @entity3 , @entity7 , @entity6 and @entity8 under @entity4 conditions has been implicated in invadopodia formation, @entity1 invasiveness and @entity0 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity5 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity5 , 8 cases of @entity1 ( @entity1 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity3 , anti- @entity7 , anti- @entity6 and anti- @entity8 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity5 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity5 exhibited increased presence of proteins associated with @entity1 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity1 . This article is protected by copyright. All rights reserved.

title: Role of @entity4 -related proteins in invasion of XXXX cells: crosstalk between @entity3 , @entity6 , @entity7 , and @entity8 .

answer: @entity5


abstract: AIMS: @entity5 ( @entity5 ) is a @entity1 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity2 concentration is reduced in specific areas of the @entity1 microenvironment, which leads to intratumoral @entity4 . Crosstalk between @entity3 , @entity7 , @entity6 and @entity8 under @entity4 conditions has been implicated in invadopodia formation, @entity1 invasiveness and @entity0 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity5 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity5 , 8 cases of @entity1 ( @entity1 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity3 , anti- @entity7 , anti- @entity6 and anti- @entity8 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity5 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity5 exhibited increased presence of proteins associated with @entity1 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity1 . This article is protected by copyright. All rights reserved.

title: Role of XXXX -related proteins in invasion of @entity5 cells: crosstalk between @entity3 , @entity6 , @entity7 , and @entity8 .

answer: @entity4


abstract: AIMS: @entity5 ( @entity5 ) is a @entity1 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity2 concentration is reduced in specific areas of the @entity1 microenvironment, which leads to intratumoral @entity4 . Crosstalk between @entity3 , @entity7 , @entity6 and @entity8 under @entity4 conditions has been implicated in invadopodia formation, @entity1 invasiveness and @entity0 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity5 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity5 , 8 cases of @entity1 ( @entity1 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity3 , anti- @entity7 , anti- @entity6 and anti- @entity8 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity5 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity5 exhibited increased presence of proteins associated with @entity1 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity1 . This article is protected by copyright. All rights reserved.

title: Role of @entity4 -related proteins in invasion of @entity5 cells: crosstalk between @entity3 , @entity6 , @entity7 , and XXXX .

answer: @entity8


abstract: AIMS: @entity5 ( @entity5 ) is a @entity1 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity2 concentration is reduced in specific areas of the @entity1 microenvironment, which leads to intratumoral @entity4 . Crosstalk between @entity3 , @entity7 , @entity6 and @entity8 under @entity4 conditions has been implicated in invadopodia formation, @entity1 invasiveness and @entity0 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity5 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity5 , 8 cases of @entity1 ( @entity1 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity3 , anti- @entity7 , anti- @entity6 and anti- @entity8 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity5 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity5 exhibited increased presence of proteins associated with @entity1 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity1 . This article is protected by copyright. All rights reserved.

title: Role of @entity4 -related proteins in invasion of @entity5 cells: crosstalk between @entity3 , XXXX , @entity7 , and @entity8 .

answer: @entity6


abstract: UNASSIGNED: The DNA repair pathway mismatch repair (MMR) is responsible for the recognition and correction of DNA biosynthetic errors caused by inaccurate @entity5 incorporation during replication. Faulty MMR leads to failure to address the mispairs or insertion deletion loops (IDLs) left behind by the replicative polymerases and results in increased mutation load at the genome. The realization that defective MMR leads to a hypermutation phenotype and increased risk of tumorigenesis highlights the relevance of this pathway for @entity0 disease. The association of MMR defects with increased risk of @entity1 development was first observed in @entity2 @entity0 that carried inactivating germline mutations in MMR genes and the disease was named as @entity2 ( @entity2 ). Currently, a growing list of @entity1 is found to be MMR defective and @entity2 has been renamed @entity4 ( @entity4 ) partly to include the associated risk of developing @entity3 . In addition, a number of non-hereditary, mostly epigenetic, alterations of MMR genes have been described in @entity1 . Besides conferring a strong @entity1 predisposition, genetic or epigenetic inactivation of MMR genes also renders cells resistant to some chemotherapeutic agents. Therefore, diagnosis of @entity6 has important implications for the management of the @entity0 , the surveillance of their relatives in the case of @entity4 and for the choice of treatment. Some of the alterations found in MMR genes have already been well defined and their pathogenicity assessed. Despite this substantial wealth of knowledge, the effects of a large number of alterations remain uncharacterized (variants of uncertain significance, VUSs). The advent of personalized genomics is likely to increase the list of VUSs found in MMR genes and anticipates the need of diagnostic tools for rapid assessment of their pathogenicity. This review describes current tools and future strategies for addressing the relevance of MMR gene alterations in @entity0 disease.

title: Approaches to diagnose DNA mismatch repair gene defects in XXXX .

answer: @entity1


abstract: BACKGROUND: It is unknown, whether cardiac troponin (cTn) I or @entity3 is the preferred biomarker in the detection of exercise-induced @entity1 . METHODS: We investigated @entity0 with suspected @entity1 referred for exercise or pharmacological rest/stress myocardial perfusion single-photon emission computed tomography (SPECT) to directly compare the diagnostic accuracy of high-sensitivity @entity2 (hs- @entity2 ) and hs- @entity3 . Diagnostic performance was analyzed separately according to stress modality. Hs- @entity2 and hs- @entity3 were measured before, immediately after, as well as 2h and 4h after maximal exercise in a blinded fashion. Further, all clinical information available to the treating cardiologist was used to quantify the clinical judgment regarding the presence of @entity1 using a visual analog scale twice: once prior and once after stress-testing. The presence of stress-induced @entity1 was adjudicated using SPECT combined with coronary angiography findings. RESULT: A total of 403 consecutive @entity0 were enrolled in our study, of which 229 underwent exercise stress and 174 @entity0 pharmacological stress. Exercise-stress-induced @entity1 was detected in 90 @entity0 (39.3% of 229). Levels of hs- @entity2 and hs- @entity3 were both significantly higher at all time-points examined in @entity0 with exercise-induced @entity1 as compared to @entity0 without @entity1 (all p<0.001). Correlation of hs- @entity2 and hs- @entity3 was high in direct comparison of time-points (Spearman's rho all >= 0.7). The AUCs for baseline/peak/2h/4h for hs- @entity2 and hs- @entity3 were 0.71/0.71/0.72/0.69 vs. 0.74/0.73/0.71/0.72, respectively (all p=ns for hs- @entity2 versus hs- @entity3 ). In @entity0 undergoing pharmacological stress, the AUCs for baseline/peak/2h/4h for hs- @entity2 and hs- @entity3 were 0.66/0.66/0.68/0.67 and 0.61/0.62/0.64/0.59, respectively (all p=ns for hs- @entity2 versus hs- @entity3 ). Also the combinations including clinical judgment or changes during serial sampling were similar for hs- @entity2 and hs- @entity3 (all p=ns). CONCLUSIONS: Hs- @entity2 and hs- @entity3 provide comparable diagnostic information regarding exercise-induced @entity1 . Overall, their diagnostic accuracy seems moderate. UNIQUE IDENTIFIER: NCT01838148.

title: Direct comparison of cardiac troponin I and cardiac troponin T in the detection of exercise-induced XXXX .

answer: @entity1


abstract: AIMS: @entity1 ( @entity1 ) is considered to be one of the important risk factors for @entity2 . Frank @entity1 is usually preceded by long term abnormality in @entity3 homeostasis which is called pre- @entity1 . The hypothesis that @entity1 @entity0 have greater risk and worse prognosis of @entity4 ( @entity4 ) than pre- @entity1 is controversial. Considering that India has been declared as a @entity1 capital of the world, the study aimed to assess the load of pre @entity1 , @entity1 and non- @entity1 landing in @entity4 . MATERIALS AND METHODS: The study consisted of through physiological and biochemical evaluation of 200 @entity0 of newly diagnosed @entity4 and evaluating the load of non- @entity1 , pre- @entity1 and @entity1 among them. RESULT: It was found that the total non- @entity1 population (normoglycaemic and pre- @entity1 ) formed the bulk of @entity4 @entity0 (69%) in our study. The degree of biochemical alterations seen among the three groups suggests that abnormal @entity3 homeostasis is not the sole determinant of the severity of @entity4 . The study data also suggests that glycaemic status, which poses a risk for @entity4 , differs in male and female individuals. Males even with normal @entity3 level are at increased risk to develop MI. CONCLUSION: The study concludes that both males and females with their blood @entity3 in pre- @entity1 range are seen to be vulnerable to develop @entity4 . Thus all individuals irrespective of their glycaemic status around the age of forty should be screened and individuals with fasting sugar in pre- @entity1 range should take extra precaution in terms of healthy diet, life style and regular check up.

title: Glycaemic status in @entity0 of XXXX : A detailed analysis.

answer: @entity4


abstract: AIMS: @entity1 ( @entity1 ) is considered to be one of the important risk factors for @entity2 . Frank @entity1 is usually preceded by long term abnormality in @entity3 homeostasis which is called pre- @entity1 . The hypothesis that @entity1 @entity0 have greater risk and worse prognosis of @entity4 ( @entity4 ) than pre- @entity1 is controversial. Considering that India has been declared as a @entity1 capital of the world, the study aimed to assess the load of pre @entity1 , @entity1 and non- @entity1 landing in @entity4 . MATERIALS AND METHODS: The study consisted of through physiological and biochemical evaluation of 200 @entity0 of newly diagnosed @entity4 and evaluating the load of non- @entity1 , pre- @entity1 and @entity1 among them. RESULT: It was found that the total non- @entity1 population (normoglycaemic and pre- @entity1 ) formed the bulk of @entity4 @entity0 (69%) in our study. The degree of biochemical alterations seen among the three groups suggests that abnormal @entity3 homeostasis is not the sole determinant of the severity of @entity4 . The study data also suggests that glycaemic status, which poses a risk for @entity4 , differs in male and female individuals. Males even with normal @entity3 level are at increased risk to develop MI. CONCLUSION: The study concludes that both males and females with their blood @entity3 in pre- @entity1 range are seen to be vulnerable to develop @entity4 . Thus all individuals irrespective of their glycaemic status around the age of forty should be screened and individuals with fasting sugar in pre- @entity1 range should take extra precaution in terms of healthy diet, life style and regular check up.

title: Glycaemic status in XXXX of @entity4 : A detailed analysis.

answer: @entity0


abstract: CONTEXT: New therapies have evolved from our improved understanding of the biology of @entity5 ( @entity5 ) and the availability of a useful transgenic animal model. Several therapeutic options are available that interrupt the sickling process at various key pathways. @entity4 (NO)is a critical factor in the pathophysiology of @entity5 and is a promising antisickling agent with vasodilation properties. NO regulates blood vessel tone, endothelial adhesion, and the severity of ischaemia-reperfusion injury and @entity3 in @entity5 . Although NO is difficult to administer, its precursor, @entity6 , is an oral supplement. STARTING POINT: J R Romero and colleagues recently demonstrated in sickle @entity1 that oral @entity2 supplementation induced NO production and reduced red-cell density by inhibiting the Gardos channel, which modulates cell hydration and polymerisation of haemoglobin S (Blood 2002; 99:1103-08). Haemoglobinopathies can be cured by stem-cell transplantation. This therapy is now accepted treatment in symptomatic @entity0 . However, most @entity0 lack a genotypically identical family donor. G La Nasa and colleagues demonstrated unrelated-donor stem-cell transplantation may give similar results to related-donor stem-cell transplantation when extended phenotypic matching is used (Blood 2002; 99: 4350-56). This pilot study offers the possibility of cure to @entity0 without a family donor. WHERE NEXT: Although potential opportunities to prevent morbidity in @entity5 through new therapies are exciting, most @entity0 do not have access to standard multidisciplinary specialty care. @entity0 require both.

title: New therapies in XXXX .

answer: @entity5


abstract: Percutaneous stenting has become the procedure of choice for treatment of obstructive @entity0 . @entity1 , however, continues to be in the range of 15-25% of treated vessels. In this study, clinical and angiographic predictors of @entity1 were assessed. Of 132 vessels included, fifty-eight were followed for @entity1 using duplex Doppler (n=15), conventional angiogram (n=33) or multislice computed tomography (CT) angiogram (n=10). Fifteen vessels (26%) met the criteria for @entity1 (lesion > or =50% by conventional or CT angiography or >60% by Doppler) at a follow-up range of 2-20 months (5% <2 months; 68% 3-12 months; 27% 13-20 months). Cox Regression analyses were performed for selected variables. A p-value <0.05 was considered statistically significant. History of smoking [odds ratio (OR), 6.6:1; p=0.005] and time to evaluate for @entity1 were independent predictors of the occurrence of @entity1 . Also, a high @entity1 rate (40%) was seen in vessels < or =4 mm in diameter (n=20) in contrast to larger vessels (n=38) >4 mm (18.4%). Although statistical significance was not reached (possibly because of the small sample size), clinically this is a significant finding. A significant drop in systolic (-15.6 mmHg) and diastolic (-6.2 mmHg) blood pressures was seen following @entity0 stenting with no significant change in the total number of antihypertensives used (2.4 versus 2.5 for pre- and post-renal stenting, respectively). CONCLUSION: @entity1 occurred in 26% of successfully stented RAs. History of smoking, time to evaluate for @entity1 and small vessels (< or =4 mm) were predictors of its occurrence. Clinically, a significant drop in blood pressure was seen with @entity0 stenting without a change in the total number of antihypertensives on follow-up.

title: Clinical and angiographic predictors of XXXX stenting.

answer: @entity0


abstract: A @entity0 given intravesical BCG immunotherapy developed @entity8 . After resection of a superficial @entity1 , the @entity0 was given weekly intravesical BCG infusions. After the 4th session, the @entity0 developed @entity2 (40 degrees C), shivers, dry cough, profuse sweating, and @entity5 . Initially, the chest x-ray was normal. The @entity0 was given isoniazid (5 mg/kg) in a single-drug regimen. Rapid degradation of the general status led to a new chest x-ray, 10 days later, which demonstrated a @entity7 . High-resolution thoracic CT confirmed the diagnosis of @entity8 . A three-drug antituberculosis regimen associated with @entity4 was followed by restoration of the general status. Antituberculosis therapy was continued for 9 months. The 9-month thoracic CT revealed a smaller number of micronodules in the @entity6 . This case illustrates the discussion concerning the appropriate treatment for @entity0 who develop a @entity3 after intravesical BCG-therapy.

title: [ XXXX following intravesical BCG-therapy].

answer: @entity8


abstract: AIM: To assess the level of evidence for subjective and objective parameters in clinical orofacial examination and determine if predictors for @entity2 ( @entity2 ) involvement in @entity3 ( @entity3 ) @entity0 exist in the current literature. METHOD: A comprehensive systematic electronic search strategy was performed in all major medical databases in June 2015. Studies were selected independently by two reviewers in accordance with a prespecified protocol and a risk of bias assessment for all included studies. Subjective examination outcome measures assessed were @entity1 , decreased @entity2 function, and @entity2 sounds. The objective outcome measures assessed were maximal incisor opening, mandibular asymmetric opening, condylar translation, protrusion, @entity1 on palpation, @entity4 , and micro- or retrognathism. RESULTS: The electronic database search identified 345 unique citations. After application of our strict, predefined inclusion and exclusion criteria, 21 articles were included and data extracted. The study heterogeneity did not allow for meta-analyses. No singular outcome measure can be suggested as a predictor of @entity2 involvement in @entity3 , as sensitivity and/or specificity is too low compared to contrast-enhanced magnetic resonance imaging. CONCLUSION: The current low level of evidence and study heterogeneity do not allow us to conclude on singular clinical outcome measures. To increase study comparability, we call for a standardized terminology and evidence-based guidelines for clinical orofacial examination parameters in @entity3 @entity0 .

title: Clinical predictors of temporomandibular joint arthritis in XXXX : A systematic literature review.

answer: @entity3


abstract: @entity0 with @entity3 levels over 1,000 mg/dl are at high risk of developing acute @entity4 . This study aimed to determine the effectiveness of plasma exchange (PE) in reducing @entity3 levels during an acute attack of @entity4 ( @entity4 ). A total of 17 @entity8 @entity0 with the complication of acute @entity4 received one course of PE treatment for one or two consecutive sessions. The respective mean removal rates during a single PE for @entity3 , @entity1 , amylase, and lipase were 66.3, 62.1, 70.0, and 84.8%, respectively. An additional one exchange increased the removal rate to 83.3, 66.2, 85.5, and 87.0%, respectively. For the two-sessions of treatment, the removal rates were higher for @entity3 (P=0.0015) and amylase with a borderline statistical significance (P=0.0641). Better @entity3 clearance correlated well with lower levels of transmembrane pressure ( @entity6 ) at 90 minutes after PE (r2=0.5782, P=0.0010) and shorter plasmapheresis duration (r2=0.2241, P=0.0427). Thirteen of seventeen @entity0 (76.5%) recovered completely, eight @entity0 in a single-session, and five in two-sessions. Two @entity0 developed @entity7 , necessitating surgical drainage and two @entity0 died due to both @entity2 and @entity5 . No significant predictor of clinical outcome was identified. In summary, PE treatment is an effective method to clear lipids and enzymes from plasma in a single session for most @entity4 @entity0 . A greater extraction of @entity3 would result in a reduced @entity6 and a shorter duration of PE treatment.

title: Plasmapheresis for XXXX .

answer: @entity4


abstract: INTRODUCTION: Approximately 60 000 prosthetic valves are implanted annually in the USA. The risk of prosthesis dysfunction ranges from 0.1% to 4% per year. Prosthesis @entity4 is usually caused by a @entity7 obstructing the prosthetic discs. However, 10% of prosthetic valves are dysfunctional due to @entity11 formation, and 12% of prostheses are damaged by both fibrinous and @entity7 components. The authors present two @entity0 with dysfunctional aortic prostheses who were referred for cardiac surgery. Different surgical solutions were used in the treatment of each case. CASE STUDY 1: The first @entity0 was a 71-year-old @entity0 whose medical history included arterial @entity2 , stable @entity6 , @entity1 , @entity10 ( @entity10 ), and @entity9 ; she had previously undergone left-sided mastectomy and radiotherapy. The @entity0 was admitted to the Cardiac Surgery Department due to @entity13 . Transthoracic echocardiography revealed @entity14 and a severe reduction in the mobility of the second. The mean transvalvular gradient was very high. During the operation, @entity11 covering the discs' surface was found. A biological aortic prosthesis was reimplanted without complications. CASE STUDY 2: The second @entity0 was an 87-year-old @entity0 with arterial @entity2 , persistent @entity8 , and @entity10 , whose past medical history included @entity12 and @entity5 . As in the case of the first @entity0 , she was admitted due to @entity4 . Preoperative transthoracic echocardiography revealed an obstruction of the posterior prosthetic disc and significant @entity3 . Transesophageal echocardiography and fluoroscopy confirmed the prosthetic dysfunction. During the operation, a @entity7 growing around a minor @entity11 was found. The @entity7 and @entity11 were removed, and normal functionality of the prosthetic valve was restored. CONCLUSIONS: Precise and modern diagnostic methods facilitated selection of the treatment method. However, the intraoperative view also seems to be crucial in individualizing the surgical approach.

title: Artificial aortic valve dysfunction due to XXXX and @entity7 - different methods of cardiac surgical management.

answer: @entity11


abstract: INTRODUCTION: Approximately 60 000 prosthetic valves are implanted annually in the USA. The risk of prosthesis dysfunction ranges from 0.1% to 4% per year. Prosthesis @entity4 is usually caused by a @entity7 obstructing the prosthetic discs. However, 10% of prosthetic valves are dysfunctional due to @entity11 formation, and 12% of prostheses are damaged by both fibrinous and @entity7 components. The authors present two @entity0 with dysfunctional aortic prostheses who were referred for cardiac surgery. Different surgical solutions were used in the treatment of each case. CASE STUDY 1: The first @entity0 was a 71-year-old @entity0 whose medical history included arterial @entity2 , stable @entity6 , @entity1 , @entity10 ( @entity10 ), and @entity9 ; she had previously undergone left-sided mastectomy and radiotherapy. The @entity0 was admitted to the Cardiac Surgery Department due to @entity13 . Transthoracic echocardiography revealed @entity14 and a severe reduction in the mobility of the second. The mean transvalvular gradient was very high. During the operation, @entity11 covering the discs' surface was found. A biological aortic prosthesis was reimplanted without complications. CASE STUDY 2: The second @entity0 was an 87-year-old @entity0 with arterial @entity2 , persistent @entity8 , and @entity10 , whose past medical history included @entity12 and @entity5 . As in the case of the first @entity0 , she was admitted due to @entity4 . Preoperative transthoracic echocardiography revealed an obstruction of the posterior prosthetic disc and significant @entity3 . Transesophageal echocardiography and fluoroscopy confirmed the prosthetic dysfunction. During the operation, a @entity7 growing around a minor @entity11 was found. The @entity7 and @entity11 were removed, and normal functionality of the prosthetic valve was restored. CONCLUSIONS: Precise and modern diagnostic methods facilitated selection of the treatment method. However, the intraoperative view also seems to be crucial in individualizing the surgical approach.

title: Artificial aortic valve dysfunction due to @entity11 and XXXX - different methods of cardiac surgical management.

answer: @entity7


abstract: BACKGROUND: Japan has four seasons and many chances of low atmospheric pressure or approaches of typhoon, therefore it has been empirically known that the fluctuation of weather induces @entity2 in @entity0 . Generally, its mechanism has been interpreted as follows: physical loading, attributed by atmospheric pressure to @entity0 bodies, compresses or dilates @entity0 blood vessels, which leads to abnormality in blood flow and induces @entity2 . We report our examination of the stage in which @entity2 tends to be induced focusing on the variation of atmospheric pressure. FINDINGS: Subjects were 34 @entity0 with @entity2 , who were treated in our hospital. The @entity0 included 31 females and three males, whose mean age was 32      6.7. 22 @entity0 had @entity3 and 12 @entity0 had @entity4 . All of @entity0 with @entity2 maintained a @entity1 diary to record atmospheric pressures when they developed a @entity2 . The standard atmospheric pressure was defined as 1013  hPa, and with this value as the criterion, we investigated slight fluctuations in the atmospheric pressure when they developed a @entity2 . It was found that the atmospheric pressure when the @entity0 developed a @entity2 was within 1003-1007  hPa in the approach of low atmospheric pressure and that the @entity0 developed a @entity2 when the atmospheric pressure decreased by 6-10  hPa, slightly less than the standard atmospheric pressure. CONCLUSION: Small decreases of 6-10  hPa relative to the standard atmospheric pressure of 1013  hPa induced @entity2 attacks most frequently in @entity0 with @entity2 .

title: Examination of fluctuations in atmospheric pressure related to XXXX .

answer: @entity2


abstract: OBJECTIVE: To evaluate the sensitivity and specificity of immunohistochemical (IHC) staining of DNA mismatch repair (MMR) protein for the screening of @entity2 ( @entity2 ) @entity1 ( @entity1 ). METHODS: A total of 255 @entity1 cases were studied, including 140 cases of routine paraffin-embedded tissue samples and 115 cases constructed on tissue microarray. Expressions of 4 MMR proteins including MHL1, @entity3 , @entity4 and @entity5 were investigated by IHC. Negative protein expression was defined as complete absence of nuclear staining within @entity0 cells in the presence of positively labeled internal non-neoplastic cells. Focal staining was defined as the presence of staining in < 5% of the @entity0 cells. CRCs showing negative staining for any MMR proteins were interpreted as MMR deficient @entity0 . PCR-genescan @entity2 analysis was performed in each case by a five marker panel including Bat26, Bat25, NR-21, NR-24 and MONO-27. RESULTS: Among the 140 CRCs with routine formalin-fixed paraffin embedded tissue sections, concordance rate between IHC and PCR-genescan was 98.6% (138/140), the sensitivity and specificity of IHC in detecting @entity0 were 94.9% (37/39) and 100.0% (101/101), respectively. The 2 disconcordant cases showed focal staining in at least one of the MMR proteins but were confirmed to be @entity2 CRCs by PCR-genescan assay. On tissue microarray, 91.3% (105/115) of the cases had informative results. The concordance rate between IHC and PCR-genescan was 100.0% (105/105). Both the specificity and sensitivity of IHC in detecting @entity0 on available tissue microarray samples were 100.0%. Ten cases were inclusive due to the presence of negative stains of MMR proteins in both the @entity0 and internal control cells. CONCLUSIONS: Detection of 4 MMR proteins expression by IHC is reliable for identifying @entity2 CRCs and is recommended for routine practice. @entity0 with focal MMR protein staining are highly suspected for the presence of @entity2 and PCR-genescan based @entity2 analysis should be performed to confirm.

title: [Value of detection of DNA mismatch repair proteins deficiency by immunohistochemistry in predicting XXXX microsatellite status].

answer: @entity0


abstract: BACKGROUND: Red cell distribution width (RDW) is associated with morbidity and mortality in chronic @entity3 . The aim of the present study was to investigate the role of RDW as a predictor of adverse outcome in @entity0 with @entity5 . MATERIALS AND METHODS: We prospectively studied 1065 of 1286 consecutive @entity0 with neurological asymptomatic @entity4 as assessed by duplex Doppler sonography. The study endpoints were all-cause mortality and cardiovascular mortality respectively. RESULTS: During a median follow-up time of 6.2 years (interquartile range 5.9 to 6.6), corresponding to 5,551 overall @entity0 -years, 275 @entity0 (25.8%) died. Of these, 182 @entity0 (66.2%) died due to cardiovascular causes. RDW was significantly associated with adverse outcome. In a continuous multivariate Cox regression analysis, the adjusted hazard ratio for each percent increase in RDW was 1.39 (95% CI 1.27-1.53; p<0.001) for all-cause and 1.43 (95% CI 1.28-1.60; p<0.001) for cardiovascular mortality, respectively. Kaplan-Meier estimates showed a gradual relationship between increasing quartiles of RDW and @entity2 (log rank p<0.001). Adjusted hazard ratios for all-cause @entity2 ranged from 0.89 to 1.94 for the highest versus the lowest quartile (p<0.001 for trend) and for @entity1 from 1.08 to 2.34 for the highest versus the lowest quartile (p<0.001 for trend), respectively. CONCLUSIONS: RDW was significantly and independently associated with all-cause and @entity1 in @entity0 with asymptomatic @entity5 . This article is protected by copyright. All rights reserved.

title: Red cell distribution width and mortality in XXXX .

answer: @entity5


abstract: OBJECTIVES: To summarize the characteristics of backfill in @entity0 with @entity2 (SpA) and @entity0 with @entity1 ( @entity1 ) and healthy controls, and to assess the value of backfill in diagnosing axial SpA. METHODS: Three readers blinded recorded backfill seen on T1SE MRI scans from 647  subjects: 297  @entity0 with @entity2 ( @entity2 ), 126  @entity0 with non-radiographic axial SpA (nr-axSpA), 147  @entity0 with @entity1 , and 77  healthy controls. The SPARCC SIJ Structural Score (SSS) method was used to assess backfill. The changes of backfill were evaluated by the follow-up MRI scans from 157  @entity0 . We summarized the characteristics of backfill and calculated its sensitivity and specificity for diagnosing axial SpA. RESULTS: Backfill was recorded in 78.8% @entity2 @entity0 , 11.1% nr-axSpA @entity0 , 1.8% @entity0 with @entity1 , and no healthy control. Backfill affected more frequently at ilium bone, lower half of sacroiliac joints in axial SpA (both P<0.05). The SSS score of backfill was much higher in axial SpA than in @entity0 with @entity1 (both P<0.01) and it did not correlate with demographics and BASDAI, BASFI, and CRP (all P>0.05). The score of backfill only positively correlated with symptom duration in @entity2 (r=0.251, P<0.01) and in nr-axSpA (r=0.743, P<0.01) @entity0 . Only 8.9% @entity0 had the change of backfill in an average follow-up time of 1.09  years. Backfill had high specificity (0.98) and moderate sensitivity (0.59) for diagnosing axial SpA. CONCLUSIONS: We summarized the characteristics of backfill and found that backfill is a specific sign of axial SpA seen on T1SE MRI.

title: Backfill is a specific sign of XXXX seen on MRI.

answer: @entity2


abstract: Eleven pairs of symmetrically conjoined twins underwent surgical separation at the Queen Sirikit National Institute of @entity0 Health. Six were omphalopagus, 4 were thoracopagus and 1 was pygopagus. Eight were female and 3 were male. Three pairs were separated on emergency or semi-emergency bases, and the remaining 8 pairs were separated electively at an older age. Of the 3 pairs who had early emergency separations, one pair, whose combined birth weight was only 2,500 g, underwent emergency separation at the age of 44 days after the death of one twin. The second twin also expired one hour after the separation. In the remaining 2 pairs, early separation was done because of the deterioration of one twin due to @entity1 . In both cases, the @entity0 with @entity1 expired but the others survived the separation satisfactorily. In one pair of @entity2 , one twin had cyanotic @entity1 . They were electively separated at the age of 2 years and 9 months. The twin with @entity1 expired 2 hours after surgery, but the other survived the separation satisfactorily. In the remaining 7 pairs who underwent elective separations, both twins of each pair survived the separation satisfactorily. However, one twin expired unexpectedly 10 days after the separation.

title: XXXX : surgical separation in 11 cases.

answer: @entity2


abstract: UNASSIGNED: The aim of this study is to investigate the epidemiology, diagnosis, treatment and risk factors of @entity3 @entity0 with @entity1 ( @entity1 ) in China. We analyzed @entity3 ( @entity3 ) @entity0 receiving chemotherapy in a prospective multicenter study. Basic characteristics, the diagnosis, and treatment of @entity1 were recorded. A total of 395 @entity3 @entity0 were enrolled, who received a total of 443 chemotherapy courses. Among them, 17 IFDs were diagnosed during one chemotherapy course. Fourteen of these were possible @entity1 and 3 were probable @entity1 . Ten of the 14 @entity0 with possible @entity1 had @entity2 . Thirty eight (8.6  %) patients received antifungal prophylaxis, and 47.4  % of them were administered with @entity4 . @entity0 who had a history of @entity1 or underwent a combined therapy with two antibiotics for over 7  days and with a history of @entity5 or ductus venosus insertion were more likely to be treated with antifungal prophylaxis. All of first-line antifungal therapies were monotherapy. Eleven (84.6  %) cases were treated with @entity6 . The median time of initial antifungal therapy was 8  days. The general condition of two @entity0 with probable @entity1 and 10 @entity0 (90.9  %) with possible @entity1 improved, while 1 @entity0 with possible @entity1 died. Multivariate analysis revealed that history of @entity1 is an independent risk factor of @entity1 . The present multicenter study suggests that the incidence of @entity1 per chemotherapy courses in @entity3 @entity0 is 3.8  % and most @entity0 are labelled as having possible @entity1 . @entity4 is the most common antifungal agent for prophylaxis and @entity7 for therapeutic treatment. Previous @entity1 is a probable independent risk factor of @entity1 in @entity3 @entity0 receiving chemotherapy.

title: Epidemiology and treatment of invasive fungal diseases in @entity0 with XXXX : findings from a multicenter prospective study from China.

answer: @entity3


abstract: UNASSIGNED: The aim of this study is to investigate the epidemiology, diagnosis, treatment and risk factors of @entity3 @entity0 with @entity1 ( @entity1 ) in China. We analyzed @entity3 ( @entity3 ) @entity0 receiving chemotherapy in a prospective multicenter study. Basic characteristics, the diagnosis, and treatment of @entity1 were recorded. A total of 395 @entity3 @entity0 were enrolled, who received a total of 443 chemotherapy courses. Among them, 17 IFDs were diagnosed during one chemotherapy course. Fourteen of these were possible @entity1 and 3 were probable @entity1 . Ten of the 14 @entity0 with possible @entity1 had @entity2 . Thirty eight (8.6  %) patients received antifungal prophylaxis, and 47.4  % of them were administered with @entity4 . @entity0 who had a history of @entity1 or underwent a combined therapy with two antibiotics for over 7  days and with a history of @entity5 or ductus venosus insertion were more likely to be treated with antifungal prophylaxis. All of first-line antifungal therapies were monotherapy. Eleven (84.6  %) cases were treated with @entity6 . The median time of initial antifungal therapy was 8  days. The general condition of two @entity0 with probable @entity1 and 10 @entity0 (90.9  %) with possible @entity1 improved, while 1 @entity0 with possible @entity1 died. Multivariate analysis revealed that history of @entity1 is an independent risk factor of @entity1 . The present multicenter study suggests that the incidence of @entity1 per chemotherapy courses in @entity3 @entity0 is 3.8  % and most @entity0 are labelled as having possible @entity1 . @entity4 is the most common antifungal agent for prophylaxis and @entity7 for therapeutic treatment. Previous @entity1 is a probable independent risk factor of @entity1 in @entity3 @entity0 receiving chemotherapy.

title: Epidemiology and treatment of invasive fungal diseases in XXXX with @entity3 : findings from a multicenter prospective study from China.

answer: @entity0


abstract: UNASSIGNED: @entity2 ( @entity2 ) represent the most common @entity1 group in the age group of 20 to 40-years old @entity0 . The potentially curable effect of cytotoxic therapy in @entity2 is mediated mainly by the induction of apoptosis. Autophagy has been discussed as an alternative mechanism of cell death but also of treatment resistance in various types of @entity1 . However, in @entity2 the expression and role of core autophagy-associated factors is hitherto unknown. We designed the study in order to evaluate the potential role of autophagy-associated factors in the development and progression of @entity1 . Eighty-four @entity0 were assessed for autophagy ( @entity4 , @entity5 ) and apoptosis (cleaved caspase  3) markers using immunohistochemistry (IHC) on tissue micro- arrays. In addition, western blot analyses of frozen tissue of @entity3 and @entity3 were performed. Our findings show that @entity4 was significantly upregulated in @entity3 as compared to @entity3 but not to normal testicular tissue. No significant difference of @entity5 expression was detected between neoplastic and normal tissue or between @entity3 and @entity3 . @entity4 and @entity5 showed distinct loco  -regional expression patterns in normal and neoplastic @entity0 testicular tissues. In contrast to the autophagic markers, apoptosis rate was significantly higher in @entity1 as compared to normal testicular tissue, but not between different @entity2 subtypes. The present study, for the first time, examined the expression of central autophagy proteins @entity4 and @entity5 in @entity1 . Our findings imply that in general apoptosis but not autophagy induction differs between normal and neoplastic testis tissue.

title: Autophagy-associated proteins @entity4 and @entity5 in XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity2 ( @entity2 ) represent the most common @entity1 group in the age group of 20 to 40-years old @entity0 . The potentially curable effect of cytotoxic therapy in @entity2 is mediated mainly by the induction of apoptosis. Autophagy has been discussed as an alternative mechanism of cell death but also of treatment resistance in various types of @entity1 . However, in @entity2 the expression and role of core autophagy-associated factors is hitherto unknown. We designed the study in order to evaluate the potential role of autophagy-associated factors in the development and progression of @entity1 . Eighty-four @entity0 were assessed for autophagy ( @entity4 , @entity5 ) and apoptosis (cleaved caspase  3) markers using immunohistochemistry (IHC) on tissue micro- arrays. In addition, western blot analyses of frozen tissue of @entity3 and @entity3 were performed. Our findings show that @entity4 was significantly upregulated in @entity3 as compared to @entity3 but not to normal testicular tissue. No significant difference of @entity5 expression was detected between neoplastic and normal tissue or between @entity3 and @entity3 . @entity4 and @entity5 showed distinct loco  -regional expression patterns in normal and neoplastic @entity0 testicular tissues. In contrast to the autophagic markers, apoptosis rate was significantly higher in @entity1 as compared to normal testicular tissue, but not between different @entity2 subtypes. The present study, for the first time, examined the expression of central autophagy proteins @entity4 and @entity5 in @entity1 . Our findings imply that in general apoptosis but not autophagy induction differs between normal and neoplastic testis tissue.

title: Autophagy-associated proteins XXXX and @entity5 in @entity1 .

answer: @entity4


abstract: UNASSIGNED: @entity2 ( @entity2 ) represent the most common @entity1 group in the age group of 20 to 40-years old @entity0 . The potentially curable effect of cytotoxic therapy in @entity2 is mediated mainly by the induction of apoptosis. Autophagy has been discussed as an alternative mechanism of cell death but also of treatment resistance in various types of @entity1 . However, in @entity2 the expression and role of core autophagy-associated factors is hitherto unknown. We designed the study in order to evaluate the potential role of autophagy-associated factors in the development and progression of @entity1 . Eighty-four @entity0 were assessed for autophagy ( @entity4 , @entity5 ) and apoptosis (cleaved caspase  3) markers using immunohistochemistry (IHC) on tissue micro- arrays. In addition, western blot analyses of frozen tissue of @entity3 and @entity3 were performed. Our findings show that @entity4 was significantly upregulated in @entity3 as compared to @entity3 but not to normal testicular tissue. No significant difference of @entity5 expression was detected between neoplastic and normal tissue or between @entity3 and @entity3 . @entity4 and @entity5 showed distinct loco  -regional expression patterns in normal and neoplastic @entity0 testicular tissues. In contrast to the autophagic markers, apoptosis rate was significantly higher in @entity1 as compared to normal testicular tissue, but not between different @entity2 subtypes. The present study, for the first time, examined the expression of central autophagy proteins @entity4 and @entity5 in @entity1 . Our findings imply that in general apoptosis but not autophagy induction differs between normal and neoplastic testis tissue.

title: Autophagy-associated proteins @entity4 and XXXX in @entity1 .

answer: @entity5


abstract: PURPOSE: The goal of our study was to determine the benefits of screening by non-mydriatic retinal camera in the @entity4 region and to present the results of this screening. @entity0 AND METHODS: We report a prospective study of 430  @entity1 @entity0 , or 860  eyes, compiled between December  2012 and June  2013 in the Dokkarat health center, "integrated referral center for management of @entity1 and @entity2 " in the region of @entity4 . All @entity0 underwent an examination by non-mydriatic fundus camera, obtaining two digital images per eye. The photos are taken by a nurse and a general practitioner. Interpretation of the images was performed in the ophthalmology department of the Hassan  II University Medical Center of @entity4 . RESULTS: A total of 430  @entity0 were screened (78.4% female, 21.6% male). The mean age was 54.7  years (range, 10-80  years). The average duration of @entity1 was 7.7  years (  5.9). Most @entity0 had @entity3  2 @entity1 (94%). Insulin therapy was found in 35.3%. The mean HbA1c (obtained from 421  @entity0 ) was 8.21%. 38,8% of @entity0 had never consulted an ophthalmologist before. The fundus photographs were not interpretable for at least one eye in 75  cases (17.4%). Among the interpretable images, the prevalence of @entity1 ( @entity1 ) was 44.6%. @entity1 was present in at least one eye in 2.5% and @entity1 in 32  cases (9%). After screening, 69% of @entity0 with @entity1 were seen by the ophthalmologist. CONCLUSION: These data confirm the benefits of screening by non-mydriatic retinal camera, because it helps reintegrate @entity0 into the healthcare system and thus provides a real benefit in terms of public health and prevention of complications.

title: [Screening for @entity1 by non-mydriatic retinal camera in the region of XXXX ].

answer: @entity4


abstract: PURPOSE: The goal of our study was to determine the benefits of screening by non-mydriatic retinal camera in the @entity4 region and to present the results of this screening. @entity0 AND METHODS: We report a prospective study of 430  @entity1 @entity0 , or 860  eyes, compiled between December  2012 and June  2013 in the Dokkarat health center, "integrated referral center for management of @entity1 and @entity2 " in the region of @entity4 . All @entity0 underwent an examination by non-mydriatic fundus camera, obtaining two digital images per eye. The photos are taken by a nurse and a general practitioner. Interpretation of the images was performed in the ophthalmology department of the Hassan  II University Medical Center of @entity4 . RESULTS: A total of 430  @entity0 were screened (78.4% female, 21.6% male). The mean age was 54.7  years (range, 10-80  years). The average duration of @entity1 was 7.7  years (  5.9). Most @entity0 had @entity3  2 @entity1 (94%). Insulin therapy was found in 35.3%. The mean HbA1c (obtained from 421  @entity0 ) was 8.21%. 38,8% of @entity0 had never consulted an ophthalmologist before. The fundus photographs were not interpretable for at least one eye in 75  cases (17.4%). Among the interpretable images, the prevalence of @entity1 ( @entity1 ) was 44.6%. @entity1 was present in at least one eye in 2.5% and @entity1 in 32  cases (9%). After screening, 69% of @entity0 with @entity1 were seen by the ophthalmologist. CONCLUSION: These data confirm the benefits of screening by non-mydriatic retinal camera, because it helps reintegrate @entity0 into the healthcare system and thus provides a real benefit in terms of public health and prevention of complications.

title: [Screening for XXXX by non-mydriatic retinal camera in the region of @entity4 ].

answer: @entity1


abstract: OBJECTIVE: To report the incidence and analyze the factor predisposing to @entity2 after orthotopic liver transplantation (OLTx). METHODS: A retrospective study was made for the @entity0 who develop of all cases in which @entity0 presented with @entity2 after OLTx from April 1993 to December 2001 in the First Affiliated Hospital of Sun Yat-sen University, Guangzhou. RESULTS: Eighty-nine liver transplants were performed in 88 @entity0 . @entity2 developed in 65 (73%) @entity0 . Among these 65 complications, 6 were @entity1 , 9 were @entity6 , 59 were @entity3 and 5 were @entity4 . portoperative mortality rate related to @entity2 was 12.4% (11/89). Except for the preexisting @entity5 , the unbalance between coagulant and anticoagulant function in @entity0 after OLTx may play a role in @entity1 after OLTx. @entity6 was correlated with massive intraoperative blood transplantation (chi2=5.714, P<0.05). CONCLUSION: @entity2 are common after OLTx. They are severe and highly related to mortality. The unbalance between coagulant and anticoagulant function in @entity0 after OLTx resulting in the @entity7 in coronary artery may be the cause of @entity1 . Massive intraoperative blood transplantation may be responsible for @entity6 .

title: [The clinical management of XXXX after orthotopic liver transplantation].

answer: @entity2


abstract: @entity0 @entity3 ( @entity3 ) is the autoantigen recognized by anti-liver cytosol type 1 (LC1) autoantibodies in @entity2 ( @entity2 ) @entity0 . In @entity1 , this octameric protein is localized on the Golgi apparatus and binds brain microtubules (MTs) and vimentin. Subcellular localization of @entity0 @entity3 and its implication in the pathogenesis of @entity2 are unknown. Localization of the @entity0 @entity3 in @entity0 hepatocytes was done using indirect immunofluorescence and subcellular fractionations followed by in vitro binding techniques. The @entity3 antigen at two distinct locations in hepatocytes, free in the cytosol and associated with the Golgi membranes are recognized by anti-liver cytosol type 1 autoantibodies. The @entity0 @entity3 binds reversibly to the Golgi membranes and this complex formation is increased by anti-liver cytosol type 1 autoantibodies. Finally, @entity0 @entity3 does not interact with liver-specific cytoskeleton proteins. Anti-liver cytosol type 1 autoantibodies are directed against the mature high molecular form of @entity0 @entity3 . Therefore, the subcellular location of the protein may influence the production of autoantibodies and their role in the pathogenesis of @entity2 . This antigen-driven response does not appear to be facilitated or enhanced by a possible interaction between @entity0 @entity3 and hepatocyte cytoskeleton proteins.

title: Characterization of the antigenicity of the XXXX in @entity2 .

answer: @entity3


abstract: @entity0 @entity3 ( @entity3 ) is the autoantigen recognized by anti-liver cytosol type 1 (LC1) autoantibodies in @entity2 ( @entity2 ) @entity0 . In @entity1 , this octameric protein is localized on the Golgi apparatus and binds brain microtubules (MTs) and vimentin. Subcellular localization of @entity0 @entity3 and its implication in the pathogenesis of @entity2 are unknown. Localization of the @entity0 @entity3 in @entity0 hepatocytes was done using indirect immunofluorescence and subcellular fractionations followed by in vitro binding techniques. The @entity3 antigen at two distinct locations in hepatocytes, free in the cytosol and associated with the Golgi membranes are recognized by anti-liver cytosol type 1 autoantibodies. The @entity0 @entity3 binds reversibly to the Golgi membranes and this complex formation is increased by anti-liver cytosol type 1 autoantibodies. Finally, @entity0 @entity3 does not interact with liver-specific cytoskeleton proteins. Anti-liver cytosol type 1 autoantibodies are directed against the mature high molecular form of @entity0 @entity3 . Therefore, the subcellular location of the protein may influence the production of autoantibodies and their role in the pathogenesis of @entity2 . This antigen-driven response does not appear to be facilitated or enhanced by a possible interaction between @entity0 @entity3 and hepatocyte cytoskeleton proteins.

title: Characterization of the antigenicity of the @entity3 in XXXX .

answer: @entity2


abstract: PURPOSE: To investigate the feasibility of raster scanned heavy charged particle therapy in the treatment of @entity2 (PCa,) with special regard to the influence of internal organ motion on the dose distribution. METHODS AND MATERIALS: The CT data of 8 @entity0 with PCa who underwent three-dimensional conformal radiotherapy (RT) were chosen. In addition to the routine treatment planning scan, three to five additional positioning control CT scans were performed. The organs at risk and the target volumes were defined on all CT scans. Primary and boost @entity3 ion plans were calculated to deliver 66 Gy to the clinical target volume/planning target volume, with an additional 10 Gy to the gross @entity1 volume (GTV). To estimate the influence of internal organ motion on plan quality, the dose was recalculated on the basis of the control CT scans. The comparative analysis was based on the dose-volume histogram-derived physical parameters. RESULTS: The average 90% target coverage was 99.1% for the GTV. The maximal dose to the rectum was 71.8 Gy. The average rectal mean dose was 19 Gy. The volume of the rectum receiving 70 and 68 Gy was 0.1 and 0.3 cm3. The average difference in the 90% coverage for the GTV on control CT cubes was 3.6%. The maximal rectal dose increased to 76.2 Gy. The deviation in the mean rectal dose was <1 Gy on average. The rectal volume receiving 70 and 68 Gy increased to 2.5 and 3.3 cm3. CONCLUSION: The investigation demonstrated the feasibility of raster scanned @entity3 ions for PCa RT. Excellent coverage of the target volume and optimal sparing of the rectum were acquired. The combination of photon intensity-modulated RT and a @entity3 ion boost to the GTV is the most rational solution for the gain of clinical experience in heavy ion RT for PCa @entity0 .

title: Evaluation of therapeutic potential of heavy ion therapy for @entity0 with locally advanced XXXX .

answer: @entity2


abstract: PURPOSE: To investigate the feasibility of raster scanned heavy charged particle therapy in the treatment of @entity2 (PCa,) with special regard to the influence of internal organ motion on the dose distribution. METHODS AND MATERIALS: The CT data of 8 @entity0 with PCa who underwent three-dimensional conformal radiotherapy (RT) were chosen. In addition to the routine treatment planning scan, three to five additional positioning control CT scans were performed. The organs at risk and the target volumes were defined on all CT scans. Primary and boost @entity3 ion plans were calculated to deliver 66 Gy to the clinical target volume/planning target volume, with an additional 10 Gy to the gross @entity1 volume (GTV). To estimate the influence of internal organ motion on plan quality, the dose was recalculated on the basis of the control CT scans. The comparative analysis was based on the dose-volume histogram-derived physical parameters. RESULTS: The average 90% target coverage was 99.1% for the GTV. The maximal dose to the rectum was 71.8 Gy. The average rectal mean dose was 19 Gy. The volume of the rectum receiving 70 and 68 Gy was 0.1 and 0.3 cm3. The average difference in the 90% coverage for the GTV on control CT cubes was 3.6%. The maximal rectal dose increased to 76.2 Gy. The deviation in the mean rectal dose was <1 Gy on average. The rectal volume receiving 70 and 68 Gy increased to 2.5 and 3.3 cm3. CONCLUSION: The investigation demonstrated the feasibility of raster scanned @entity3 ions for PCa RT. Excellent coverage of the target volume and optimal sparing of the rectum were acquired. The combination of photon intensity-modulated RT and a @entity3 ion boost to the GTV is the most rational solution for the gain of clinical experience in heavy ion RT for PCa @entity0 .

title: Evaluation of therapeutic potential of heavy ion therapy for XXXX with locally advanced @entity2 .

answer: @entity0


abstract: Three obstetric groups matched for parity, age, color, marital and socioeconomic status, were compared for the psychosocial antecedents to abortion or term delivery and sequelae that did exist. One group had induced abortion by suction curettage, the second had induced abortion by saline injection, and the third had term delivery. 373 @entity0 were interviewed during pregnancy; 211 were included in follow-up after an average of 16 months for abortion @entity0 and 13 months for the term delivery group. The 373 @entity0 received a structured 90-minute interview about family relationships, consort relationships, living arrangements, income, education, religious behavior, sexual behavior, contraceptive knowledge and use, pregnancy history and desired family size. The Srole @entity2 scale and the Rosenberg Self-Esteem scale were also used. At the followup interview, similar questions were asked and the two attitude scales were again presented. The MMPI (Minnesota Multiphasic Personality Inventory) and the SCL (Symptom Check List) were also used. 12% of the 211 follow-up scored higher than 70 on the MMPI for @entity1 and psychopathy scales; these @entity0 were evenly divided among the three groups. SCL scales showed the three groups of @entity0 to be similar after abortion or birth, with the only statistically significant difference being the suction curettage group, which had fewer complaints after abortion than either of the other two groups. There was no difference on the @entity2 or self-esteem scale between pre- or post-procedure for any of the groups. The data suggest neither great harm nor great benefit with regard to these variables due to either @entity3 or term birth. Early abortion by suction curettage was possibly more therapeutic than carrying a pregnancy to term. There were striking improvements with regard to contraceptive use after the procedure. 71% of each group used effective contraception for more than 12 months after abortion or birth: a 20% increase for the term birth group, a 13% increase for the suction curettage group, and a 26% increase for the saline abortion group. Among abortion @entity0 , those found to have low self-esteem, low contraceptive knowledge, high alienation, and who delayed in seeking abortion were related to long recovery times, a high MMPI psychopathology scale, and a number of unpleasant body symptoms post-abortion. These @entity0 could be predicted with accuracy 32% better than chance alone.

title: Psychiatric sequelae to term birth and induced XXXX : a longitudinal study.

answer: @entity3


abstract: The majority of @entity3 among @entity0 after renal transplantation is attributed to @entity1 ( @entity1 ). @entity2 ( @entity2 ) of the common carotid artery is related to @entity7 . One of the major causes of @entity3 due to @entity1 is @entity12 , which is precipitated by @entity6 and subsequent @entity10 . The aim of the study was to evaluate associations between some fibrinolytic factors: antigens of @entity15 ( @entity15 ), plasminogen activator inhibitor ( @entity14 ), and @entity9 ( @entity9 ), and @entity2 in a population of renal transplant recipients. The study was performed on 33 Caucasian, clinically stable kidney transplant recipients (11 @entity0 , mean age 43 years, range 26 to 62 years). All the @entity0 were on triple immunosuppressive regimen ( @entity4 , @entity5 , and @entity8 ) and had stable graft function (serum @entity11 1.7 +/- 0.7 mg/dL). The mean time since transplantation was 49.9 months (range 4.1 to 131.8 months). In univariate analysis @entity2 correlated significantly with age (r =.5; P =.001), pulse pressure (PP) (r =.4; P =.05), time on dialysis prior to transplantation (r =.6; P =.001), @entity13 (r =.4; P =.02), and @entity15 (r =.6; P =.001). Multiple regression analysis showed that @entity15 antigen concentration (P =.001), @entity13 (P <.05), and time on dialysis prior to transplantation (P <.05) were positive independent predictors of @entity2 . These data support the concept of the coincidence of disturbances in fibrinolysis and arterial remodelling in @entity0 after kidney transplantation. On the other hand the study shows that the duration of dialysis therapy before transplantation is detrimental to the arterial vasculature.

title: Plasma XXXX , @entity13 , and time on dialysis prior to transplantation are related to carotid intima media thickness in renal transplant recipients.

answer: @entity15


abstract: The majority of @entity3 among @entity0 after renal transplantation is attributed to @entity1 ( @entity1 ). @entity2 ( @entity2 ) of the common carotid artery is related to @entity7 . One of the major causes of @entity3 due to @entity1 is @entity12 , which is precipitated by @entity6 and subsequent @entity10 . The aim of the study was to evaluate associations between some fibrinolytic factors: antigens of @entity15 ( @entity15 ), plasminogen activator inhibitor ( @entity14 ), and @entity9 ( @entity9 ), and @entity2 in a population of renal transplant recipients. The study was performed on 33 Caucasian, clinically stable kidney transplant recipients (11 @entity0 , mean age 43 years, range 26 to 62 years). All the @entity0 were on triple immunosuppressive regimen ( @entity4 , @entity5 , and @entity8 ) and had stable graft function (serum @entity11 1.7 +/- 0.7 mg/dL). The mean time since transplantation was 49.9 months (range 4.1 to 131.8 months). In univariate analysis @entity2 correlated significantly with age (r =.5; P =.001), pulse pressure (PP) (r =.4; P =.05), time on dialysis prior to transplantation (r =.6; P =.001), @entity13 (r =.4; P =.02), and @entity15 (r =.6; P =.001). Multiple regression analysis showed that @entity15 antigen concentration (P =.001), @entity13 (P <.05), and time on dialysis prior to transplantation (P <.05) were positive independent predictors of @entity2 . These data support the concept of the coincidence of disturbances in fibrinolysis and arterial remodelling in @entity0 after kidney transplantation. On the other hand the study shows that the duration of dialysis therapy before transplantation is detrimental to the arterial vasculature.

title: Plasma @entity15 , XXXX , and time on dialysis prior to transplantation are related to carotid intima media thickness in renal transplant recipients.

answer: @entity13


abstract: The present paper combines the estimates of efficacy and side effects of 10 mg @entity3 for emergency contraception obtained from randomized trials. A total of 6083 @entity0 participating in 12 randomized trials and receiving 10 mg @entity3 for emergency contraception up to 120 h after intercourse, were analyzed for efficacy. Between 4188 and 5833 @entity0 were analyzed for side effects and 3601 for delay of menses of more than 7 days. Prevented fractions, the effect of delay and of further acts of intercourse after treatment administration were analyzed in 3440 @entity0 , using individual data. The combined pregnancy rate from all the 12 trials was 1.7% [101/6083, 95% confidence interval (CI): 1.3-2.2]. From the three trials providing individual data, the combined pregnancy rate was 1.3% (45/3440, 95% CI: 0.9-1.7) and the estimate of pregnancies prevented was 83.4% (95% CI: 77.4-87.8). There was a sharp decline in efficacy when treatment was administered during the 5th day after intercourse compared to administration during the 1st day, the odds of pregnancy increasing by a factor of 5.3 (95% CI: 1.9-14.9). The relative risk of pregnancy was about 28 times higher among @entity0 with unprotected acts of coitus between treatment administration and the onset of next menses, compared with @entity0 reporting none [odds ratio (OR) = 27.6, 95% CI: 12.7-60.2]. The increase in risk for @entity0 reporting protected acts of intercourse during this interval was not statistically significant (OR = 1.8, 95% CI: 0.9-3.8). There was a large heterogeneity among trials in all side effects and delay of menses of more than 7 days (all had p < 0.0001 for the test of homogeneity). The percentage of @entity0 with @entity1 ranged from 0.0-19.4% (highest upper 95% confidence limit: 23.0%), that of vomiting from 0.0-4.3% (highest upper 95% confidence limit: 6.1%), that of lower @entity2 from 4.3-19.1% (highest upper 95% confidence limit: 22.7%). The percentage of @entity0 with delay of menses of more than 7 days ranged from 4.3-25.8% (highest upper 95% confidence limit: 34.1%). We conclude that 10 mg @entity3 is an effective emergency contraception regimen, with an acceptable side-effects profile. Postponing treatment until the 5th day seriously decreases efficacy. The risk of pregnancy is dramatically increased among @entity0 having unprotected acts of intercourse between treatment administration and the onset of next menses. This risk may be enhanced for @entity0 whose ovulation is postponed by treatment.

title: Combined estimates of effectiveness of XXXX 10 mg in emergency contraception.

answer: @entity3


abstract: @entity0 @entity10 ( @entity10 ) is a recently discovered member of the tissue kallikrein family of secreted @entity4 proteases, which includes @entity9 / @entity5 , the @entity1 biomarker to date. Given that @entity10 is hormonally regulated, differentially expressed in endocrine-related @entity1 , and a prognostic marker for @entity6 at the mRNA level, we hypothesize that its encoded protein, @entity7 , like @entity9 / @entity5 , may constitute a new biomarker for endocrine-related @entity1 . The objective of this study was to generate immunological reagents for @entity7 , to develop an ELISA and immunohistochemical techniques to study its expression in normal and cancerous tissues and biological fluids. Recombinant @entity7 was produced in @entity8 , purified by affinity chromatography, and injected into @entity2 and rabbits for polyclonal antibody generation. Using the @entity2 and rabbit antisera, a sandwich-type immunofluorometric ELISA and immunohistochemical methodologies were developed for @entity7 . The ELISA was sensitive (detection limit of 0.1 micro g/liter), specific for @entity7 , linear from 0 to 20 micro g/liter with between-run and within-run coefficients of variation of <10%. @entity7 was quantified in @entity0 tissue extracts and biological fluids. Highest levels were observed in the breast, skin, prostate, seminal plasma, and amniotic fluid, with almost undetectable levels in normal serum. @entity7 concentration was higher in 40% of @entity3 tissues compared with normal ovarian tissues. Serum @entity7 levels were elevated in a proportion of @entity0 with ovarian (65%) and breast (40%) @entity1 . Immunohistochemical analyses indicated strong cytoplasmic staining of @entity7 by the epithelial cells of normal and malignant skin, ovary, breast, and testis. In conclusion, we report the first ELISA and immunohistochemical assays for @entity7 and describe its distribution in tissues and biological fluids. Our preliminary data indicate that @entity7 is a potential biomarker for @entity6 .

title: @entity0 kallikrein 14: a new potential biomarker for XXXX .

answer: @entity6


abstract: @entity0 @entity10 ( @entity10 ) is a recently discovered member of the tissue kallikrein family of secreted @entity4 proteases, which includes @entity9 / @entity5 , the @entity1 biomarker to date. Given that @entity10 is hormonally regulated, differentially expressed in endocrine-related @entity1 , and a prognostic marker for @entity6 at the mRNA level, we hypothesize that its encoded protein, @entity7 , like @entity9 / @entity5 , may constitute a new biomarker for endocrine-related @entity1 . The objective of this study was to generate immunological reagents for @entity7 , to develop an ELISA and immunohistochemical techniques to study its expression in normal and cancerous tissues and biological fluids. Recombinant @entity7 was produced in @entity8 , purified by affinity chromatography, and injected into @entity2 and rabbits for polyclonal antibody generation. Using the @entity2 and rabbit antisera, a sandwich-type immunofluorometric ELISA and immunohistochemical methodologies were developed for @entity7 . The ELISA was sensitive (detection limit of 0.1 micro g/liter), specific for @entity7 , linear from 0 to 20 micro g/liter with between-run and within-run coefficients of variation of <10%. @entity7 was quantified in @entity0 tissue extracts and biological fluids. Highest levels were observed in the breast, skin, prostate, seminal plasma, and amniotic fluid, with almost undetectable levels in normal serum. @entity7 concentration was higher in 40% of @entity3 tissues compared with normal ovarian tissues. Serum @entity7 levels were elevated in a proportion of @entity0 with ovarian (65%) and breast (40%) @entity1 . Immunohistochemical analyses indicated strong cytoplasmic staining of @entity7 by the epithelial cells of normal and malignant skin, ovary, breast, and testis. In conclusion, we report the first ELISA and immunohistochemical assays for @entity7 and describe its distribution in tissues and biological fluids. Our preliminary data indicate that @entity7 is a potential biomarker for @entity6 .

title: XXXX kallikrein 14: a new potential biomarker for @entity6 .

answer: @entity0


abstract: PURPOSE: To determine the effect of digital rectal examination findings, sextant biopsy results, and @entity3 levels on reader accuracy in the localization of @entity2 with endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging. MATERIALS AND METHODS: This was a retrospective study of 37 @entity0 (mean age, 57 years) with biopsy-proved @entity2 . Transverse T1-weighted, transverse high-spatial-resolution, and coronal T2-weighted MR images and MR spectroscopic images were obtained. Two independent readers, unaware of clinical data, recorded the size and location of suspicious peripheral zone @entity1 nodules on a standardized diagram of the prostate. Readers also recorded their degree of diagnostic confidence for each nodule on a five-point scale. Both readers repeated this interpretation with knowledge of rectal examination findings, sextant biopsy results, and @entity3 level. Step-section histopathologic findings were the reference standard. Logistic regression analysis with generalized estimating equations was used to correlate @entity1 detection with clinical data, and alternative free-response receiver operating characteristic (AFROC) curve analysis was used to examine the overall effect of clinical data on all positive results. RESULTS: Fifty-one peripheral zone @entity1 nodules were identified at histopathologic evaluation. Logistic regression analysis showed awareness of clinical data significantly improved @entity1 detection rate (P <.02) from 15 to 19 nodules for reader 1 and from 13 to 19 nodules for reader 2 (27%-37% overall) by using both size and location criteria. AFROC analysis showed no significant change in overall reader performance because there was an associated increase in the number of false-positive findings with awareness of clinical data, from 11 to 21 for reader 1 and from 16 to 25 for reader 2. CONCLUSION: Awareness of clinical data significantly improves reader detection of @entity2 nodules with endorectal MR imaging and MR spectroscopic imaging, but there is no overall change in reader accuracy, because of an associated increase in false-positive findings. A stricter definition of a true-positive result is associated with reduced sensitivity for @entity2 nodule detection.

title: XXXX localization with endorectal MR imaging and MR spectroscopic imaging: effect of clinical data on reader accuracy.

answer: @entity2


abstract: BACKGROUND: Lung auscultation and bedside chest radiography are routinely used to assess the respiratory condition of ventilated @entity0 with @entity2 ( @entity2 ). Clinical experience suggests that the diagnostic accuracy of these procedures is poor. METHODS: This prospective study of 32 @entity0 with @entity2 and 10 healthy volunteers was performed to compare the diagnostic accuracy of auscultation, bedside chest radiography, and lung ultrasonography with that of thoracic computed tomography. Three pathologic entities were evaluated in 384 lung regions (12 per @entity0 ): @entity4 , and @entity5 . RESULTS: Auscultation had a diagnostic accuracy of 61% for @entity4 , 36% for @entity1 , and 55% for @entity5 . Bedside chest radiography had a diagnostic accuracy of 47% for @entity4 , 75% for @entity1 , and 72% for @entity5 . Lung ultrasonography had a diagnostic accuracy of 93% for @entity4 , 97% for @entity1 , and 95% for @entity5 . Lung ultrasonography, in contrast to auscultation and chest radiography, could quantify the extent of @entity3 . Interobserver agreement for the ultrasound findings as assessed by the kappa statistic was satisfactory: 0.74, 0.77, and 0.73 for detection of @entity5 , @entity1 , and @entity4 , respectively. CONCLUSIONS: At the bedside, lung ultrasonography is highly sensitive, specific, and reproducible for diagnosing the main lung pathologic entities in @entity0 with @entity2 and can be considered an attractive alternative to bedside chest radiography and thoracic computed tomography.

title: Comparative diagnostic performances of auscultation, chest radiography, and lung ultrasonography in XXXX .

answer: @entity2


abstract: There is evidence that 8q amplification is associated with poor prognosis in @entity2 . A previous comparative genomic hybridization analysis identified a critical region in chromosomal bands 8q11.2-q13. Using restriction landmark genomic scanning in combination with a virtual genome scan, we showed that this region is delineated by sequences within contig NT_008183 of chromosomal subbands 8q11.22-q11.23. A real-time PCR-based genomic copy number assay of 20 @entity2 revealed @entity1 in this critical chromosomal region in eight @entity0 . The expression of four genes and expressed sequence tags (ESTs) within this newly defined region was assayed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in four @entity0 with and six @entity0 without @entity1 . The @entity4 oncogene was found to be highly expressed in all but one @entity0 compared to normal liver tissue. Furthermore, quantitative RT-PCR revealed that the expression level of the developmentally regulated transcription factor @entity4 was 3-12 times greater in @entity0 and cell lines compared to age-matched normal liver and comparable to the expression in fetal liver tissue. @entity4 has been shown be a transcriptional activator of @entity3 in other @entity0 types. Using luciferase reporter assays, we demonstrated that @entity4 transactivates transcription from the embryonic @entity3 promoter P3, also in @entity2 cell lines. Thus, our results provide evidence that @entity4 overexpression may be responsible for the frequently observed up-regulation of @entity3 in @entity2 and therefore may be implicated in the molecular pathogenesis of this childhood @entity0 .

title: Amplification and overexpression of the XXXX regulator @entity4 in @entity2 .

answer: @entity3


abstract: There is evidence that 8q amplification is associated with poor prognosis in @entity2 . A previous comparative genomic hybridization analysis identified a critical region in chromosomal bands 8q11.2-q13. Using restriction landmark genomic scanning in combination with a virtual genome scan, we showed that this region is delineated by sequences within contig NT_008183 of chromosomal subbands 8q11.22-q11.23. A real-time PCR-based genomic copy number assay of 20 @entity2 revealed @entity1 in this critical chromosomal region in eight @entity0 . The expression of four genes and expressed sequence tags (ESTs) within this newly defined region was assayed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) in four @entity0 with and six @entity0 without @entity1 . The @entity4 oncogene was found to be highly expressed in all but one @entity0 compared to normal liver tissue. Furthermore, quantitative RT-PCR revealed that the expression level of the developmentally regulated transcription factor @entity4 was 3-12 times greater in @entity0 and cell lines compared to age-matched normal liver and comparable to the expression in fetal liver tissue. @entity4 has been shown be a transcriptional activator of @entity3 in other @entity0 types. Using luciferase reporter assays, we demonstrated that @entity4 transactivates transcription from the embryonic @entity3 promoter P3, also in @entity2 cell lines. Thus, our results provide evidence that @entity4 overexpression may be responsible for the frequently observed up-regulation of @entity3 in @entity2 and therefore may be implicated in the molecular pathogenesis of this childhood @entity0 .

title: Amplification and overexpression of the @entity3 regulator @entity4 in XXXX .

answer: @entity2