abstract: PURPOSE: To determine why Polish @entity0 included in the International @entity2 Trial (IST) had a higher early case @entity9 than @entity0 from other countries. METHODS: Of 19,435 @entity0 randomised to IST, 17,370 had CT or autopsy-confirmed @entity2 . We compared the baseline clinical state and 14-day case @entity9 of @entity0 randomised in Polish centres with those from all other IST countries. We examined: age, gender, presence of @entity7 ( @entity7 ), conscious level, @entity1 , cause of @entity5 and @entity4 use in the 3 days before @entity2 . RESULTS: In Poland, the 14-day case @entity9 rate was significantly higher than in other IST countries (13% vs. 9.6%; odds ratio, OR, 1.5, 95% confidence interval, CI, 1.2-1.9). In Poland, a significantly higher proportion of @entity5 was attributed to @entity6 (2.5% vs. 0.7%) and @entity8 (1.0% vs. 0.4%). Polish @entity0 had higher percentage of @entity7 and drowsiness, but were younger. When these factors were adjusted for, Polish @entity0 still had approximately a 57% higher risk of @entity5 within 14 days compared with other countries. A logistic regression analysis revealed that an increased risk of @entity5 within 14 days in Poland compared to other IST @entity0 was present among @entity0 younger than 75 years (OR 1.7; 95% CI 1.3-2.4), females (OR 1.8; 95% CI 1.3-2.5), @entity0 who were alert at onset (OR 2.4; 95% CI 1.7-3.4), with partial anterior circulation syndrome (PACS) (OR 2.0; 95% CI 1.4-2.8) or @entity10 ( @entity10 ) (OR 2.4; 95% CI 1.1-5.0) and without @entity7 (OR 1.8; 95% CI 1.3-2.4). Polish @entity0 were less likely to have been on @entity4 before their @entity2 than other countries (7.6% vs. 20.8%). CONCLUSION: The 14-day case @entity9 was significantly higher in Poland than in other countries in IST. Part of the increase was due to greater @entity2 severity in the Polish @entity0 . However, differences persisted even after adjustment for baseline @entity2 severity. Several factors may have contributed the excess: poor attention to treatment of @entity3 , less attention to treatment of secondary complications of @entity2 and some other--as yet unidentified--factor specific to Poland.

title: High early case @entity9 after XXXX in Poland: exploration of possible explanations in the International @entity2 Trial.

answer: @entity2


abstract: PURPOSE: To determine why Polish @entity0 included in the International @entity2 Trial (IST) had a higher early case @entity9 than @entity0 from other countries. METHODS: Of 19,435 @entity0 randomised to IST, 17,370 had CT or autopsy-confirmed @entity2 . We compared the baseline clinical state and 14-day case @entity9 of @entity0 randomised in Polish centres with those from all other IST countries. We examined: age, gender, presence of @entity7 ( @entity7 ), conscious level, @entity1 , cause of @entity5 and @entity4 use in the 3 days before @entity2 . RESULTS: In Poland, the 14-day case @entity9 rate was significantly higher than in other IST countries (13% vs. 9.6%; odds ratio, OR, 1.5, 95% confidence interval, CI, 1.2-1.9). In Poland, a significantly higher proportion of @entity5 was attributed to @entity6 (2.5% vs. 0.7%) and @entity8 (1.0% vs. 0.4%). Polish @entity0 had higher percentage of @entity7 and drowsiness, but were younger. When these factors were adjusted for, Polish @entity0 still had approximately a 57% higher risk of @entity5 within 14 days compared with other countries. A logistic regression analysis revealed that an increased risk of @entity5 within 14 days in Poland compared to other IST @entity0 was present among @entity0 younger than 75 years (OR 1.7; 95% CI 1.3-2.4), females (OR 1.8; 95% CI 1.3-2.5), @entity0 who were alert at onset (OR 2.4; 95% CI 1.7-3.4), with partial anterior circulation syndrome (PACS) (OR 2.0; 95% CI 1.4-2.8) or @entity10 ( @entity10 ) (OR 2.4; 95% CI 1.1-5.0) and without @entity7 (OR 1.8; 95% CI 1.3-2.4). Polish @entity0 were less likely to have been on @entity4 before their @entity2 than other countries (7.6% vs. 20.8%). CONCLUSION: The 14-day case @entity9 was significantly higher in Poland than in other countries in IST. Part of the increase was due to greater @entity2 severity in the Polish @entity0 . However, differences persisted even after adjustment for baseline @entity2 severity. Several factors may have contributed the excess: poor attention to treatment of @entity3 , less attention to treatment of secondary complications of @entity2 and some other--as yet unidentified--factor specific to Poland.

title: High early case @entity9 after @entity2 in Poland: exploration of possible explanations in the International XXXX Trial.

answer: @entity2


abstract: PURPOSE: To determine why Polish @entity0 included in the International @entity2 Trial (IST) had a higher early case @entity9 than @entity0 from other countries. METHODS: Of 19,435 @entity0 randomised to IST, 17,370 had CT or autopsy-confirmed @entity2 . We compared the baseline clinical state and 14-day case @entity9 of @entity0 randomised in Polish centres with those from all other IST countries. We examined: age, gender, presence of @entity7 ( @entity7 ), conscious level, @entity1 , cause of @entity5 and @entity4 use in the 3 days before @entity2 . RESULTS: In Poland, the 14-day case @entity9 rate was significantly higher than in other IST countries (13% vs. 9.6%; odds ratio, OR, 1.5, 95% confidence interval, CI, 1.2-1.9). In Poland, a significantly higher proportion of @entity5 was attributed to @entity6 (2.5% vs. 0.7%) and @entity8 (1.0% vs. 0.4%). Polish @entity0 had higher percentage of @entity7 and drowsiness, but were younger. When these factors were adjusted for, Polish @entity0 still had approximately a 57% higher risk of @entity5 within 14 days compared with other countries. A logistic regression analysis revealed that an increased risk of @entity5 within 14 days in Poland compared to other IST @entity0 was present among @entity0 younger than 75 years (OR 1.7; 95% CI 1.3-2.4), females (OR 1.8; 95% CI 1.3-2.5), @entity0 who were alert at onset (OR 2.4; 95% CI 1.7-3.4), with partial anterior circulation syndrome (PACS) (OR 2.0; 95% CI 1.4-2.8) or @entity10 ( @entity10 ) (OR 2.4; 95% CI 1.1-5.0) and without @entity7 (OR 1.8; 95% CI 1.3-2.4). Polish @entity0 were less likely to have been on @entity4 before their @entity2 than other countries (7.6% vs. 20.8%). CONCLUSION: The 14-day case @entity9 was significantly higher in Poland than in other countries in IST. Part of the increase was due to greater @entity2 severity in the Polish @entity0 . However, differences persisted even after adjustment for baseline @entity2 severity. Several factors may have contributed the excess: poor attention to treatment of @entity3 , less attention to treatment of secondary complications of @entity2 and some other--as yet unidentified--factor specific to Poland.

title: High early case XXXX after @entity2 in Poland: exploration of possible explanations in the International @entity2 Trial.

answer: @entity9


abstract: The incidence of @entity0 based solely on @entity3 ( @entity3 ) score was compared with a protocol using a combination of @entity3 score plus a score for @entity1 (ED score). The population of @entity2 studied included 425 Bernese mountain @entity2 and 22 @entity2 of other breeds. The overall agreement between the two systems was high. However, 12 per cent of @entity3 -score negative cases were positive using the ED score. This difference was statistically significant (P < 0.005). The female:male ratio of the @entity2 missed using the @entity3 score was 2:1. The proportion of @entity2 affected with @entity3 increased with age, male @entity2 being affected more frequently. The development of @entity3 depends not only on age and breed, but probably also on gender. Thus, screening for @entity4 should be based on at least two radiographic projections, including @entity3 and @entity1 . As the vast majority of @entity2 in this study were Bernese mountain @entity2 , conclusions are valid only for this breed.

title: Comparison of two classification protocols in the evaluation of XXXX in the @entity2 .

answer: @entity4


abstract: The incidence of @entity0 based solely on @entity3 ( @entity3 ) score was compared with a protocol using a combination of @entity3 score plus a score for @entity1 (ED score). The population of @entity2 studied included 425 Bernese mountain @entity2 and 22 @entity2 of other breeds. The overall agreement between the two systems was high. However, 12 per cent of @entity3 -score negative cases were positive using the ED score. This difference was statistically significant (P < 0.005). The female:male ratio of the @entity2 missed using the @entity3 score was 2:1. The proportion of @entity2 affected with @entity3 increased with age, male @entity2 being affected more frequently. The development of @entity3 depends not only on age and breed, but probably also on gender. Thus, screening for @entity4 should be based on at least two radiographic projections, including @entity3 and @entity1 . As the vast majority of @entity2 in this study were Bernese mountain @entity2 , conclusions are valid only for this breed.

title: Comparison of two classification protocols in the evaluation of @entity4 in the XXXX .

answer: @entity2


abstract: PURPOSE: There are limited data about the effectiveness of surgery in @entity0 with painful varicocele. We report a retrospective study done for the follow up on all varicocele high ligations performed for @entity1 to evaluate the effectiveness of the operations. MATERIALS AND METHODS: The @entity0 who were all physically active workers and who underwent high inguinal ligation of varicocele for @entity1 from January 1995 to January 2000, were invited for interviews. Their charts were reviewed to document @entity0 age, grade and location of varicocele, duration and quality of @entity1 , response to conservative treatment. All @entity0 who could be contacted were interviewed for resolution of @entity1 and complications, their physical examinations were made. RESULTS: 87 of 140 (62.1%) @entity0 were available for the follow up. Median @entity0 age was 26 (15 to 34) years old. The varicocele was on the left side in 82 @entity0 and bilateral in 5. The @entity1 was dull in 42, throbbing in 25, sharp in 6 and as a pulling sensation in 14. The longest conservative therapy given in the literature failed in all @entity0 . Varicocele grades were as follows: Grade I in 17, Grade II in 34 and Grade III in 36 @entity0 . High inguinal ligation was used in all @entity0 . 72 (82.8%) @entity0 reported complete resolution, 8 (9.2%) @entity0 reported partial response, 7 (8%) @entity0 had persistant @entity1 . CONCLUSIONS: High inguinal ligation is effective in the treatment of painful varicocele in highly selected @entity0 . Prospective randomized studies are needed comparing surgical and conservative treatments.

title: High ligation to treat XXXX in varicocele.

answer: @entity1


abstract: OBJECTIVE: To describe a novel, effective, and minimally invasive surgical technique for avoiding excess @entity1 and hysterectomy in intractable postpartum @entity2 . Previously described techniques-uterine artery ligation at various levels, hypogastric (internal iliac) artery ligation, uterine compression-all require an abdominal approach. METHODS: This procedure, which is quickly learned, is performable in the delivery room with minimal preparation, with or without bladder retraction. A 2-cm horizontal incision is made in the anterior cervix 1 cm beneath the estimated vaginocervical fold and the bladder reflected in the natural plane. Firm but gentle downward traction on the uterus to the contralateral side of the intended ligature maximizes cephalad and lateral access, permitting bilateral uterine artery ligation from laterally under direct vision and/or indirect transcervical palpation. RESULTS: Between November 1997 and June 2001, 13 @entity0 with intractable postpartum @entity2 chose the vaginal route over laparotomy as a uterus-preserving procedure. Hysterectomy proved necessary in only one case (8%) because of @entity4 . One @entity0 has since delivered a healthy term @entity0 by cesarean, and uterine vascularization was unimpaired. CONCLUSION: The vaginal route offers a novel, simple, effective, and minimally invasive technique for treating intractable puerperal @entity2 by uterine artery ligation. Timely intervention avoids hysterectomy and @entity3 and preserves reproductive potential.

title: Vaginal uterine artery ligation avoids high @entity1 and puerperal hysterectomy in postpartum XXXX .

answer: @entity2


abstract: OBJECTIVE: To describe a novel, effective, and minimally invasive surgical technique for avoiding excess @entity1 and hysterectomy in intractable postpartum @entity2 . Previously described techniques-uterine artery ligation at various levels, hypogastric (internal iliac) artery ligation, uterine compression-all require an abdominal approach. METHODS: This procedure, which is quickly learned, is performable in the delivery room with minimal preparation, with or without bladder retraction. A 2-cm horizontal incision is made in the anterior cervix 1 cm beneath the estimated vaginocervical fold and the bladder reflected in the natural plane. Firm but gentle downward traction on the uterus to the contralateral side of the intended ligature maximizes cephalad and lateral access, permitting bilateral uterine artery ligation from laterally under direct vision and/or indirect transcervical palpation. RESULTS: Between November 1997 and June 2001, 13 @entity0 with intractable postpartum @entity2 chose the vaginal route over laparotomy as a uterus-preserving procedure. Hysterectomy proved necessary in only one case (8%) because of @entity4 . One @entity0 has since delivered a healthy term @entity0 by cesarean, and uterine vascularization was unimpaired. CONCLUSION: The vaginal route offers a novel, simple, effective, and minimally invasive technique for treating intractable puerperal @entity2 by uterine artery ligation. Timely intervention avoids hysterectomy and @entity3 and preserves reproductive potential.

title: Vaginal uterine artery ligation avoids high XXXX and puerperal hysterectomy in postpartum @entity2 .

answer: @entity1


abstract: PURPOSE: The purpose of this article is to evaluate whether the presence of perineural invasion (PNI) in the biopsy specimen is predictive of 5-year biochemical disease-free outcome after prostate brachytherapy. MATERIALS AND METHODS: Four hundred twenty-five @entity0 underwent transperineal ultrasound-guided prostate brachytherapy using either 103Pd or 125I for clinical T1b/T3a NXMO (1997 American Joint Committee on Cancer) @entity3 from April 1995 to October 1999. No @entity0 was lost to follow-up, and no @entity0 underwent pathological lymph node staging. Two hundred twenty-one @entity0 were implanted with 103Pd, and 204 @entity0 were implanted with 125I. Of this cohort, 190 @entity0 were implanted without supplemental beam radiation, and 235 received moderate-dose external-beam radiation therapy followed by a prostate brachytherapy boost. One hundred sixty-three @entity0 received hormonal manipulation in conjunction with the brachytherapy implant (86 of these @entity0 received moderate-dose external-beam radiation therapy before brachytherapy), and 262 @entity0 were hormone na  ve. @entity1 , defined as @entity2 tracking along or around a nerve within the perineural space, was identified in 105 @entity0 (24.7% of the population). The median @entity0 age was 68 years (range, 48-81 years). The mean follow-up was 37.1 +/- 15.2 months, and the median follow-up was 35.4 months (range, 6-74 months). Follow-up was calculated from the date of implantation. Biochemical disease-free survival was defined by the American Society of Therapeutic Radiation and Oncology (ASTRO) consensus definition. RESULTS: When Kaplan-Meier survival analysis was performed, the presence of PNI did not predict failure. When PNI was entered into a Cox regression analysis with evaluated clinical predictors of failure (age, clinical T stage, pretreatment @entity4 level, and Gleason score) or treatment parameters (use of neoadjuvant hormonal therapy, supplemental external-beam radiation therapy, and choice of isotope), PNI did not add to the predictive strength of these variables. The median disease-free @entity4 level was 0.1 ng/mL for the entire cohort. CONCLUSIONS: Our results indicate that actuarial 5-year biochemical outcomes with a prostate brachytherapy approach that utilizes generous periprostatic margins is not dependent on the presence of PNI. In addition, PNI should not be used as an independent prognosticator in determining the need for combined-modality therapy in @entity0 undergoing prostate brachytherapy.

title: XXXX is not predictive of biochemical outcome following prostate brachytherapy.

answer: @entity1


abstract: STUDY OBJECTIVES: To study the impact of filgrastim 5 microg/kg given once/day through absolute neutrophil count (ANC) recovery on the duration of grade 4 @entity2 (ANC < 0.5 x 10(3)/mm3) and time to ANC recovery. Additional objectives were to study the average number of filgrastim injections/cycle required to achieve ANC recovery and differences in outcome by cycle. DESIGN: Combined analysis of two double-blind, randomized, multicenter trials. @entity1 : Two hundred twenty-two @entity1 treated for @entity0 . MEASUREMENTS AND MAIN RESULTS: All @entity1 but one were evaluable for efficacy end points. Mean +/- SD duration of grade 4 @entity2 was 1.7 +/- 1.3 days in cycle 1; the duration decreased in cycles 2-4 to between 1.0 and 1.2 days. Fifty percent of @entity1 had ANC recovery to 10 x 10(3)/mm3 or greater by day 11 of the cycle, and 90% by day 13, corresponding to 10 and 12 days of filgrastim administration, respectively. Across all cycles, the mean +/- SD number of filgrastim injections/cycle was 10.51 +/- 1.70, with little variation among cycles. CONCLUSION: When filgrastim is administered as recommended, starting 24 hours after chemotherapy and continuing through an ANC of 10 x 10(3)/mm3 or greater, neutrophil recovery is rapid and predictable. Because the first cycle of chemotherapy has the highest rates of @entity2 and @entity2 , it seems prudent to administer growth factor support preemptively.

title: Filgrastim-mediated neutrophil recovery in @entity1 with XXXX treated with docetaxel and doxorubicin.

answer: @entity0


abstract: STUDY OBJECTIVES: To study the impact of filgrastim 5 microg/kg given once/day through absolute neutrophil count (ANC) recovery on the duration of grade 4 @entity2 (ANC < 0.5 x 10(3)/mm3) and time to ANC recovery. Additional objectives were to study the average number of filgrastim injections/cycle required to achieve ANC recovery and differences in outcome by cycle. DESIGN: Combined analysis of two double-blind, randomized, multicenter trials. @entity1 : Two hundred twenty-two @entity1 treated for @entity0 . MEASUREMENTS AND MAIN RESULTS: All @entity1 but one were evaluable for efficacy end points. Mean +/- SD duration of grade 4 @entity2 was 1.7 +/- 1.3 days in cycle 1; the duration decreased in cycles 2-4 to between 1.0 and 1.2 days. Fifty percent of @entity1 had ANC recovery to 10 x 10(3)/mm3 or greater by day 11 of the cycle, and 90% by day 13, corresponding to 10 and 12 days of filgrastim administration, respectively. Across all cycles, the mean +/- SD number of filgrastim injections/cycle was 10.51 +/- 1.70, with little variation among cycles. CONCLUSION: When filgrastim is administered as recommended, starting 24 hours after chemotherapy and continuing through an ANC of 10 x 10(3)/mm3 or greater, neutrophil recovery is rapid and predictable. Because the first cycle of chemotherapy has the highest rates of @entity2 and @entity2 , it seems prudent to administer growth factor support preemptively.

title: Filgrastim-mediated neutrophil recovery in XXXX with @entity0 treated with docetaxel and doxorubicin.

answer: @entity1


abstract: Negative @entity3 balance and accelerated muscle protein breakdown are characteristics of @entity1 . The mechanism by which muscle proteolysis occurs may be activation of the ubiquitin-proteasome pathway, but needs to be further elucidated. The aim of this study was to gain more insight into the role of ubiquitin-proteasome pathway in muscle proteolysis, after @entity1 in a @entity0 @entity1 model. The proteolytic rates and mRNA expression of ubiquitin, @entity5 in extensor digital longus (EDL) and soleus (SOL) muscle were determined by @entity2 analyzer and Northern blot, respectively. The results were as follows: the total and myofibrillar proteolytic rate of EDL muscle increased markedly, especially at 12 and 24h post-burn. The levels of 2.4kb mRNA for ubiquitin, 1.2kb mRNA for @entity5 (a rate-limiting and regulated enzyme for conjugation of ubiquitin with protein substrate) and mRNA for subunit RC2 (the largest subunit of 20S proteasome) predominantly increased in EDL muscle after the stimulation of @entity1 . No significant changes in proteolytic rate and transcription of ubiquitin, @entity5 in SOL muscle were observed. There was a significantly positive correlation between the proteolytic rate and the levels of 2.4kb mRNA for ubiquitin, 1.2kb mRNA for @entity5 , or mRNA for subunit RC2. The results indicated that @entity4 after @entity1 was mainly due to the accelerated breakdown of myofibrils, and EDL muscle was more sensitive to @entity1 than SOL muscle. The activation of ubiquitin-proteasome pathway was one reason for the enhanced protein catabolism in skeletal muscle. This is the first demonstration of upregulated expression of @entity5 in muscle, in response to @entity1 , and it provides a clue to reduce @entity4 by specifically inhibiting the specific enzymes or subunits involved in the enhancement of the activity of ubiquitin-proteasome pathway after @entity1 .

title: The relationship between skeletal muscle proteolysis and ubiquitin-proteasome proteolytic pathway in burned XXXX .

answer: @entity0


abstract: @entity1 is an important public health problem among adult @entity0 in developing countries in South and Central America, sub-Saharan Africa, and south and south-east Asia. Frequently repeated cytology screening programmes--either organized or opportunistic--have led to a large decline in @entity1 incidence and mortality in developed countries. In contrast, @entity1 remains largely uncontrolled in high-risk developing countries because of ineffective or no screening. This article briefly reviews the experience from existing screening and research initiatives in developing countries. Substantial costs are involved in providing the infrastructure, manpower, consumables, follow-up and surveillance for both organized and opportunistic screening programmes for @entity1 . Owing to their limited health care resources, developing countries cannot afford the models of frequently repeated screening of @entity0 over a wide age range that are used in developed countries. Many low-income developing countries, including most in sub-Saharan Africa, have neither the resources nor the capacity for their health services to organize and sustain any kind of screening programme. Middle-income developing countries, which currently provide inefficient screening, should reorganize their programmes in the light of experiences from other countries and lessons from their past failures. Middle-income countries intending to organize a new screening programme should start first in a limited geographical area, before considering any expansion. It is also more realistic and effective to target the screening on high-risk @entity0 once or twice in their lifetime using a highly sensitive test, with an emphasis on high coverage (>80%) of the targeted population. Efforts to organize an effective screening programme in these developing countries will have to find adequate financial resources, develop the infrastructure, train the needed manpower, and elaborate surveillance mechanisms for screening, investigating, treating, and following up the targeted @entity0 . The findings from the large body of research on various screening approaches carried out in developing countries and from the available managerial guidelines should be taken into account when reorganizing existing programmes and when considering new screening initiatives.

title: Effective screening programmes for XXXX in low- and middle-income developing countries.

answer: @entity1


abstract: INTRODUCTION: Intra-atrial reentrant @entity1 (IART) circuits after Mustard operation remain incompletely understood due to the complex atrial anatomy after extensive surgical procedures. The aim of this study was to delineate IART circuits and their relations to the individual anatomic boundaries in Mustard @entity0 . METHODS AND RESULTS: Twelve @entity0 (10 @entity0 and 2 @entity0 ; age 29 +/- 4.6 years) with @entity3 after Mustard operation were included in this study. During 14 IARTs and 2 focal @entity1 , electroanatomic mapping and entrainment mapping were performed in both the @entity2 . The latter was accessed via a retrograde transaortic approach. Thirteen IARTs used a single-loop reentrant circuit, and 1 IART used a dual-loop reentrant circuit. Ten (77%) of 13 single-loop reentrant circuits used the tricuspid annulus (TA) as their central barrier. The remaining 3 IARTs rotated around the inferior vena cava (IVC) (n = 2) or ostium of the right upper pulmonary vein (n = 1). In 6 (60%) of the 10 peritricuspid IARTs, both @entity2 components of the mid-portion of the TA-IVC isthmus were demonstrated to be part of the reentry. Overall, 12 (86%) of 14 IARTs in 10 @entity0 were successfully ablated by bridging two barriers that constrained the reentrant circuit. Eight (80%) of 10 peritricuspid circuits were abolished by linear ablation connecting the TA to the IVC (n = 4), incisional scar (n = 2), patch (n = 1), and atriotomy (n = 1). CONCLUSIONS: In Mustard @entity0 , the TA serves as the most frequent central barrier of IART. Biatrial electroanatomic mapping combined with entrainment mapping facilitates delineation of IART circuits in relation to their anatomic barriers and enables the design of individual ablation strategies to achieve high success.

title: Delineation of intra-atrial reentrant XXXX circuits after mustard operation for transposition of the great arteries using biatrial electroanatomic mapping and entrainment mapping.

answer: @entity1


abstract: OBJECTIVE: To investigate the variations in blood @entity4 levels, hemodynamic effects and @entity0 @entity2 scores during tooth extraction in @entity0 with @entity1 T2DM and @entity3 under local anesthesia with 2% @entity6 with or without @entity5 . STUDY DESIGN: This is a prospective randomized study of 70 @entity0 with T2DM with @entity3 who underwent oral surgery. The study was double blind with respect to the glycemia measurements. Blood @entity4 levels were continuously monitored for 24 hours using the MiniMed Continuous @entity4 Monitoring System. @entity0 were randomized into two groups: 35 @entity0 received 5.4 mL of 2% @entity6 , and 35 @entity0 received 5.4 mL of 2% @entity6 with 1:100,000 @entity5 . Hemodynamic parameters (blood pressure and heart rate) and @entity2 levels were also evaluated. RESULTS: There was no difference in blood @entity4 levels between the groups at each time point evaluated. Surprisingly, both groups demonstrated a significant decrease in blood @entity4 levels over time. The groups showed no significant differences in hemodynamic and @entity2 status parameters. CONCLUSION: The administration of 5.4 mL of 2% @entity6 with @entity5 neither caused @entity7 nor had any significant impact on hemodynamic or @entity2 parameters. However, lower blood @entity4 levels were observed. This is the first report using continuous blood @entity4 monitoring to show the benefits and lack of side effects of local anesthesia with @entity5 in @entity0 with @entity1 and @entity3 .

title: Local anesthesia with XXXX is safe and effective for oral surgery in @entity0 with @entity1 and @entity3 : a prospective randomized study.

answer: @entity5


abstract: OBJECTIVE: To investigate the variations in blood @entity4 levels, hemodynamic effects and @entity0 @entity2 scores during tooth extraction in @entity0 with @entity1 T2DM and @entity3 under local anesthesia with 2% @entity6 with or without @entity5 . STUDY DESIGN: This is a prospective randomized study of 70 @entity0 with T2DM with @entity3 who underwent oral surgery. The study was double blind with respect to the glycemia measurements. Blood @entity4 levels were continuously monitored for 24 hours using the MiniMed Continuous @entity4 Monitoring System. @entity0 were randomized into two groups: 35 @entity0 received 5.4 mL of 2% @entity6 , and 35 @entity0 received 5.4 mL of 2% @entity6 with 1:100,000 @entity5 . Hemodynamic parameters (blood pressure and heart rate) and @entity2 levels were also evaluated. RESULTS: There was no difference in blood @entity4 levels between the groups at each time point evaluated. Surprisingly, both groups demonstrated a significant decrease in blood @entity4 levels over time. The groups showed no significant differences in hemodynamic and @entity2 status parameters. CONCLUSION: The administration of 5.4 mL of 2% @entity6 with @entity5 neither caused @entity7 nor had any significant impact on hemodynamic or @entity2 parameters. However, lower blood @entity4 levels were observed. This is the first report using continuous blood @entity4 monitoring to show the benefits and lack of side effects of local anesthesia with @entity5 in @entity0 with @entity1 and @entity3 .

title: Local anesthesia with @entity5 is safe and effective for oral surgery in @entity0 with XXXX and @entity3 : a prospective randomized study.

answer: @entity1


abstract: OBJECTIVE: To investigate the variations in blood @entity4 levels, hemodynamic effects and @entity0 @entity2 scores during tooth extraction in @entity0 with @entity1 T2DM and @entity3 under local anesthesia with 2% @entity6 with or without @entity5 . STUDY DESIGN: This is a prospective randomized study of 70 @entity0 with T2DM with @entity3 who underwent oral surgery. The study was double blind with respect to the glycemia measurements. Blood @entity4 levels were continuously monitored for 24 hours using the MiniMed Continuous @entity4 Monitoring System. @entity0 were randomized into two groups: 35 @entity0 received 5.4 mL of 2% @entity6 , and 35 @entity0 received 5.4 mL of 2% @entity6 with 1:100,000 @entity5 . Hemodynamic parameters (blood pressure and heart rate) and @entity2 levels were also evaluated. RESULTS: There was no difference in blood @entity4 levels between the groups at each time point evaluated. Surprisingly, both groups demonstrated a significant decrease in blood @entity4 levels over time. The groups showed no significant differences in hemodynamic and @entity2 status parameters. CONCLUSION: The administration of 5.4 mL of 2% @entity6 with @entity5 neither caused @entity7 nor had any significant impact on hemodynamic or @entity2 parameters. However, lower blood @entity4 levels were observed. This is the first report using continuous blood @entity4 monitoring to show the benefits and lack of side effects of local anesthesia with @entity5 in @entity0 with @entity1 and @entity3 .

title: Local anesthesia with @entity5 is safe and effective for oral surgery in @entity0 with @entity1 and XXXX : a prospective randomized study.

answer: @entity3


abstract: OBJECTIVE: To investigate the variations in blood @entity4 levels, hemodynamic effects and @entity0 @entity2 scores during tooth extraction in @entity0 with @entity1 T2DM and @entity3 under local anesthesia with 2% @entity6 with or without @entity5 . STUDY DESIGN: This is a prospective randomized study of 70 @entity0 with T2DM with @entity3 who underwent oral surgery. The study was double blind with respect to the glycemia measurements. Blood @entity4 levels were continuously monitored for 24 hours using the MiniMed Continuous @entity4 Monitoring System. @entity0 were randomized into two groups: 35 @entity0 received 5.4 mL of 2% @entity6 , and 35 @entity0 received 5.4 mL of 2% @entity6 with 1:100,000 @entity5 . Hemodynamic parameters (blood pressure and heart rate) and @entity2 levels were also evaluated. RESULTS: There was no difference in blood @entity4 levels between the groups at each time point evaluated. Surprisingly, both groups demonstrated a significant decrease in blood @entity4 levels over time. The groups showed no significant differences in hemodynamic and @entity2 status parameters. CONCLUSION: The administration of 5.4 mL of 2% @entity6 with @entity5 neither caused @entity7 nor had any significant impact on hemodynamic or @entity2 parameters. However, lower blood @entity4 levels were observed. This is the first report using continuous blood @entity4 monitoring to show the benefits and lack of side effects of local anesthesia with @entity5 in @entity0 with @entity1 and @entity3 .

title: Local anesthesia with @entity5 is safe and effective for oral surgery in XXXX with @entity1 and @entity3 : a prospective randomized study.

answer: @entity0


abstract: @entity3 ( @entity3 ) is the most common form of primary @entity2 . It is the most common cause of chronic @entity4 and the most frequent reason for heart transplantation in young adults. There is increasing evidence demonstrating that @entity1 are involved in the pathogenesis of idiopathic @entity3 . Recent studies have shown that genetically defective @entity6 predisposes animals to @entity3 . However, the association of @entity6 with @entity3 in @entity0 has not been reported. In the current study, the whole coding region and flanking splice junction sites of the @entity6 gene were sequenced in 220 unrelated @entity0 with idiopathic @entity3 . The available relatives of the index @entity0 harboring identified mutations and 200 unrelated ethnically matched healthy individuals used as controls were also genotyped for @entity6 . The functional effect of the @entity6 mutations was analyzed in silico. As a result, two novel heterozygous @entity6 mutations, @entity7 and @entity8 , were identified in two families with @entity3 , respectively, with a mutational prevalence of ~0.91%. Genetic analyses of the pedigrees showed that in each family, the mutation co-segregated with @entity3 was transmitted as an autosomal dominant trait with complete penetrance. The missense mutations were absent in 400 control chromosomes and the altered @entity5 were completely conserved evolutionarily across various species. Functional analysis in silico indicated that the @entity6 mutations were causative. This study firstly reports the association of @entity6 mutations with enhanced susceptibility to @entity3 in @entity0 , which provides novel insight into the molecular mechanism underpinning @entity3 , and contributes to the development of novel prophylactic and therapeutic strategies for @entity3 .

title: Prevalence and spectrum of XXXX mutations associated with idiopathic dilated cardiomyopathy.

answer: @entity6


abstract: OBJECTIVES: @entity7 is a rare @entity8 that appears in less than 1% of @entity0 with @entity4 . In the literature, the generally recommended treatment is en bloc @entity2 excision with @entity5 . Based on our 12 years of experience, we discuss the necessity of performing thyroid lobectomy on @entity7 @entity0 . RESULTS: Eleven @entity7 cases were included in the study. All operations were performed at the Department of Endocrine Surgery at Ankara University Medical School. Seven of the @entity0 were male (63.6%), and the mean @entity0 age was 48.9    14.0 years. @entity6 was the most common indication for surgery (n  10, 90.9%). @entity3 was detected in 5 @entity0 (45.5%), invasive disease was detected in 5 @entity0 (45.5%) and @entity1 was detected in 1 @entity0 (9.1%). The mean follow-up period was 99.6    42.1 months, and the @entity0 ' average disease-free survival was 96.0    49.0 months. During the follow-up period, only 1 @entity0 died of metastatic @entity7 . CONCLUSION: @entity7 has a slow-growing natural progression, and regional lymph node @entity1 are uncommon. Although our study comprised few @entity0 , it nevertheless showed that in selected cases, @entity7 could be solely treated with parathyroidectomy.

title: Is local resection sufficient for XXXX ?

answer: @entity7


abstract: Several genotypic methods have been developed for determining the host origin of fecal bacteria in contaminated waters. Some of these methods rely on a host origin database to identify environmental isolates. It is not well understood to what degree these host origin isolates are geographically variable (i.e., cosmopolitan or endemic). This is important because a geographically limited host origin database may or may not be universally applicable. The objective of our study was to use one genotypic method, ribotyping, to determine the geographic variability of the fecal bacterium, @entity1 , from one location in Idaho and three locations in Georgia for @entity0 ( @entity0 ), @entity3 ( @entity3 ), @entity4 ( @entity4 ), and @entity2 ( @entity2 ). A total of 568 fecal @entity1 isolates from Kimberly, ID (125 isolates), Athens, GA (210 isolates), Brunswick, GA (102 isolates), and Tifton, GA (131 isolates), yielded 213 ribotypes. The percentage of ribotype sharing within an animal species increased with decreased distance between geographic locations for @entity0 and @entity3 , but not for @entity4 and @entity2 . When the @entity1 ribotypes among the four host species were compared at one location, the percent of unshared ribotypes was 86, 89, 81, and 79% for Kimberly, Athens, Brunswick, and Tifton, respectively. These data suggest that there is good ribotype separation among host animal species at each location. The ability to match environmental isolates to a host origin database may depend on a large number of environmental and host origin isolates that ideally are not geographically separated.

title: Geographic variability of XXXX ribotypes from animals in Idaho and Georgia.

answer: @entity1


abstract: OBJECTIVE: To report a retrospective chart review of @entity0 who developed @entity3 ( @entity3 ) or several @entity5 ( @entity5 ) recurrences after brachytherapy for treating @entity2 . @entity0 AND METHODS: In the past 3 years 18 @entity0 with devastating complications after prostate brachytherapy were referred to our centre ( @entity3 in 11, @entity5 in seven; mean age 63 years, range 60-81). All @entity0 with @entity3 initially underwent diverting colostomy (six cystoprostatectomy with closure of the @entity3 , omental interposition and urinary diversion; one prostatectomy, @entity5 closure, @entity3 closure with omentum flap and continent vesicostomy). Three @entity0 had the @entity3 closed with gracilis muscle flap using the York-Mason approach (one had a @entity5 closure and suprapubic tube; one elected to have no treatment). All @entity0 with @entity5 had received three or more procedures to resect or incise their contracture. Four had diversion with a catheterizable segment, two used an indwelling Foley catheter and one uses intermittent catheterization. RESULTS: All six @entity0 who had cystoprostatectomy with urinary diversion have had no recurrence of their @entity3 . All three treated with the York-Mason procedure healed well. One developed recurrent @entity2 and two a secondary @entity1 in the prostate or rectum ( @entity6 and neuroendocrine, respectively). The enterocystoplasty @entity0 developed @entity4 after colostomy reversal and subsequently died. In those @entity0 with @entity5 , the four who underwent urinary diversion fared well; two tolerate the indwelling catheter poorly, and the seventh uses intermittent catheterization with occasional difficulty. CONCLUSIONS: Brachytherapy with or without external irradiation can be associated with severe complications. @entity3 managed with aggressive anterior pelvic exenteration and urinary diversion can be associated with excellent results. The York-Mason procedure in @entity0 with an adequate urinary continence mechanism and bladder dynamics may provide good functional results. The presence of a secondary malignancy in @entity0 deserves further investigation. Many recurrences of a @entity5 tend be refractory to transurethral resection/incision; indwelling catheters are then poorly tolerated and @entity0 may require a major reconstructive procedure.

title: Devastating complications after brachytherapy in the treatment of XXXX .

answer: @entity2


abstract: BACKGROUND: @entity9 is one of the most common @entity5 after colorectal surgery. We sought to investigate the predictors of prolonged @entity11 following elective colon resections procedures. METHODS: The national @entity0 user files of NSQIP databases were utilized to examine the clinical outcomes of @entity0 undergoing elective colon resection during 2012-2013. Multivariate regression analysis was performed to investigate predictors of prolonged @entity11 . @entity9 was defined as no return of bowel function in 7 days. RESULTS: We sampled a total of 27,560 @entity0 who underwent colon resections; of these, 3497 (12.7%) @entity0 had prolonged @entity11 . @entity0 with @entity4 ( @entity4 ) had a significantly higher rate of prolonged @entity11 compared to @entity0 with @entity2 ( @entity2 ) (15 vs. 11.5%, AOR 1.25, P < 0.01). @entity9 was significantly associated with @entity10 (13 vs. 2.8%, AOR 2.56, P < 0.01) and @entity7 (12 vs. 2.4%, AOR 2.50, P < 0.01). Factors such as @entity6 (AOR 1.63, P < 0.01), disseminated @entity1 (AOR 1.24, P = 0.01), and @entity8 (AOR 1.27, P = 0.02) were associated with an increased risk of prolonged @entity11 , whereas oral antibiotic bowel preparation (AOR 0.77, P < 0.01) and laparoscopic surgery (AOR 0.51, P < 0.01) are associated with decreased prolonged @entity11 risk. CONCLUSIONS: @entity9 is a common condition following colon resection, with an incidence of 12.7%. Among colon surgeries, colectomy with @entity4 resulted in the highest rate of postoperative prolonged @entity11 . @entity9 is positively associated with @entity7 and @entity10 ; thus, a high index of suspicion must be had in all @entity0 with prolonged @entity3 .

title: Risk factors for prolonged XXXX following colon surgery.

answer: @entity11


abstract: UNASSIGNED: The @entity2 ( @entity2 ) drives circadian rhythms in behavioral and physiological variables, including the inflammatory response. Shift work is known to disturb circadian rhythms and is associated with increased susceptibility to develop disease. In rodents, circadian disruption due to shifted light schedules (jet lag) induced increased innate immune responses. To gain more insight into the influence of circadian disruption on the immune response, we characterized the inflammatory response in a model of rodent shift work and demonstrated that circadian disruption affected the inflammatory response to lipopolysaccharide (LPS) both in vivo and in vitro. Since food consumption is a main disturbing element in the shift work schedule, we also evaluated the inflammatory response to LPS in a group of @entity0 that had no access to food during their working hours. Our results demonstrated that the shift work schedule decreased basal @entity1 levels in the liver but not in the circulation. Despite this, we observed that shift work induced increased cytokine response after LPS stimulation in comparison to control @entity0 . Also, Kupffer cells (liver macrophages) isolated from shift work @entity0 produced more @entity1 in response to in vitro LPS stimulation, suggesting important effects of circadian desynchronization on the functionality of this cell type. Importantly, the effects of shift work on the inflammatory response to LPS were prevented when food was not available during the working schedule. Together, these results show that dissociating behavior and food intake from the synchronizing drive of the @entity2 severely disturbs the immune response.

title: Shift Work in XXXX Results in Increased Inflammatory Response after Lipopolysaccharide Administration: A Role for Food Consumption.

answer: @entity0


abstract: The purpose of this international collaborative study was to investigate the prescription patterns of antipsychotic drugs for @entity2 in East Asia and to analyze factors that affect these patterns. Prescription patterns for @entity0 admitted for treatment of @entity2 were surveyed using a standardized protocol from six East-Asian region/countries: China, Hong Kong, Japan, Korea, Singapore and Taiwan. @entity0 ' social and clinical characteristics, @entity1 symptoms, @entity3 , and adverse effects of medications were systematically assessed and recorded. Prescriptions of the first- and second-generation antipsychotic drugs were compared. A total of 2399 @entity0 were recruited. The second-generation drugs comprised 28.1% of all prescribed antipsychotics, and 46% of the antipsychotic prescriptions were in the context of polypharmacy. The mean dosage of antipsychotics for the whole sample was 675.3 + 645.1 mg @entity7 equivalents. Japan had a high frequency of prescribing high doses and polypharmacy; Singapore had a high utilization of depot injections while China had a higher prescription of @entity6 . Using multiple logistic regression analysis, distinctions in the prescription patterns of antipsychotic drugs were found: first-generation drugs were mainly for controlling @entity1 , while second-generation drugs were targeted at the alleviation of positive, negative @entity4 as well as @entity5 in @entity2 . The present collaborative study highlighted differences in the prescription patterns, especially the under-utilization of second-generation antipsychotic drugs in East Asia. The pattern of antipsychotic medication use varied from country to country and is likely to be influenced by the prevailing health-care system, the availability and cost of the drugs.

title: Antipsychotic drug prescription for XXXX in East Asia: rationale for change.

answer: @entity2


abstract: Genome-wide association studies in @entity0 @entity8 ( @entity8 ) have renewed interest in the pancreatic islet as a contributor to @entity8 risk. @entity4 resulting from @entity3 is a risk factor for @entity8 and a possible trigger of b-cell failure. In this study, microarray data were collected from @entity2 islets after overnight treatment with cytokines at concentrations consistent with the chronic low-grade @entity4 in @entity8 . Genes with a cytokine-induced change of >2-fold were then examined for associations between single @entity10 polymorphisms and the acute insulin response to @entity6 (AIRg) using data from the Genetics Underlying @entity1 in Hispanics (GUARDIAN) Consortium. Significant evidence of association was found between AIRg and single nucleotide polymorphisms in @entity12 (5q31.3), @entity13 (6p25.3), @entity14 (3q27.1), @entity11 (1q42.3), @entity15 (11p13), @entity16 (8q21.3), and @entity17 (7q21.12). To assess the potential relevance to islet function, @entity2 islets were exposed to conditions modeling low-grade @entity4 , mitochondrial stress, @entity7 ( @entity7 ) stress, glucotoxicity, and lipotoxicity. RT-PCR revealed that one or more forms of stress significantly altered expression levels of all genes except @entity12 . @entity9 -induced @entity7 stress up-regulated both @entity15 and @entity14 . Three genes confirmed microarray predictions of significant cytokine sensitivity: @entity13 was down-regulated 3.3-fold by cytokines, @entity16 was up-regulated 1.5- to 3-fold by all stressors, and @entity17 was profoundly cytokine sensitive (167-fold up-regulation). Three genes were thus closely associated with low-grade @entity4 in @entity2 islets and also with a marker for islet function (AIRg) in a @entity1 -prone @entity0 population. This islet-targeted genome-wide association scan identified several previously unrecognized candidate genes related to @entity5 during the development of @entity8 .

title: An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 XXXX .

answer: @entity1


abstract: OBJECTIVE: This paper investigates the characteristics of pharmacies that are associated with the degree of counselling provided to customers purchasing medicines. METHODS: Twelve ' @entity2 ' (research assistants posing as normal customers) purchased restricted medicines at 180 pharmacies around New Zealand. One drug ( @entity1 ) and one class of drugs (vaginal antifungals) were purchased. The amount of counselling provided was recorded, and linked to profile data on the pharmacies, obtained through a questionnaire, from Census data, and from direct observations of pharmacies. RESULTS: Location within a city, a large town, or strip shopping did not affect the level of counselling pharmacies provided. Pharmacies adjacent to medical centres gave significantly less counselling to @entity1 purchasers than other pharmacies. No consistent relationship was found between pharmacy size and the level of counselling provided. There were large differences between areas of the country. A strong negative relationship was found between the amount of counselling given about thrush, and the proportion of Pacific Island @entity0 in the population around the pharmacy. Although only some results reached statistical significance, there seems to have been a similar trend for pharmacies to provide less counselling in areas with more Maori @entity0 and with higher levels of social deprivation. CONCLUSIONS: Regional variation in the provision of pharmacy services, and in particular the tendency for pharmacies to provide less counselling in areas that are likely to have higher health care needs, must be addressed if pharmacies are to fulfil their potential as health care providers.

title: Which sorts of pharmacies provide more XXXX counselling?

answer: @entity0


abstract: OBJECTIVE: To characterize the biological function of calmodulin (CaM) from @entity7 ( @entity8 , Cs) and investigate its role in @entity10 -associated hepatic @entity3 . METHODS: The full-length sequence of CsCaM gene was isolated from Cs cDNA library and its homologues were searched using BLASTx for comparison. Bioinformatics analysis was performed to compare the homologues and predict the physiochemical characteristics and functional domains. The gene was cloned in a prokaryotic plasmid and expressed in @entity5 , and the recombinant protein was purified by affinity chromatography for immunizing @entity2 to produce polyclonal antibodies, whose titer was determined using ELISA analysis. Immunoblotting analysis was carried out to determine of the purity and antibody recognition of CsCaM. Immunofluorescence assay was employed to analyze the tissue location of the protein. A @entity2 model of @entity6 was established by introperitoneal injection of the recombinant protein. RESULTS: The recombinant CsCaM protein obtained contained 150 @entity9 with a theoretical molecular mass of 23.4 kD. CsCaM homologue had EF hand motifs. The recombinant pET-30a-CsCaM plasmid expressed in BL21 @entity5 was about 23.4 kD. The total IgG antibody titer in the immunized @entity0 reached the peak level (over 1: 51200) 2 to 4 weeks after the first injection. Immunohistochemistry showed that CsCaM located in the testis of adult @entity8 . The @entity2 receiving intraperitoneal injection of CsCaM showed severe @entity4 with mild to moderate @entity6 . CONCLUSION: The pro- @entity1 and pro- @entity3 effects of CsCaM in @entity2 liver suggest its involvement in @entity10 - associated hepatic @entity3 .

title: [Characterization of a XXXX sinensis antigen, calmodulin, and its relationship with @entity6 ].

answer: @entity7


abstract: OBJECTIVE: To characterize the biological function of calmodulin (CaM) from @entity7 ( @entity8 , Cs) and investigate its role in @entity10 -associated hepatic @entity3 . METHODS: The full-length sequence of CsCaM gene was isolated from Cs cDNA library and its homologues were searched using BLASTx for comparison. Bioinformatics analysis was performed to compare the homologues and predict the physiochemical characteristics and functional domains. The gene was cloned in a prokaryotic plasmid and expressed in @entity5 , and the recombinant protein was purified by affinity chromatography for immunizing @entity2 to produce polyclonal antibodies, whose titer was determined using ELISA analysis. Immunoblotting analysis was carried out to determine of the purity and antibody recognition of CsCaM. Immunofluorescence assay was employed to analyze the tissue location of the protein. A @entity2 model of @entity6 was established by introperitoneal injection of the recombinant protein. RESULTS: The recombinant CsCaM protein obtained contained 150 @entity9 with a theoretical molecular mass of 23.4 kD. CsCaM homologue had EF hand motifs. The recombinant pET-30a-CsCaM plasmid expressed in BL21 @entity5 was about 23.4 kD. The total IgG antibody titer in the immunized @entity0 reached the peak level (over 1: 51200) 2 to 4 weeks after the first injection. Immunohistochemistry showed that CsCaM located in the testis of adult @entity8 . The @entity2 receiving intraperitoneal injection of CsCaM showed severe @entity4 with mild to moderate @entity6 . CONCLUSION: The pro- @entity1 and pro- @entity3 effects of CsCaM in @entity2 liver suggest its involvement in @entity10 - associated hepatic @entity3 .

title: [Characterization of a @entity7 sinensis antigen, calmodulin, and its relationship with XXXX ].

answer: @entity6


abstract: INTRODUCTION: Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. @entity8 has been detected recently in some @entity0 with lone @entity5 . Virchow's triad of low blood flow, @entity2 , and @entity3 , enhances @entity4 formation. The present study was designed to elucidate the role of @entity3 in thrombogenesis associated with @entity5 . MATERIAL AND METHODS: We investigated tissue factor expression in the endothelia of left atrial appendages obtained from seven @entity0 with @entity5 and cardiogenic @entity6 . Tissues were divided into 7-13 sections and compared with control specimens from four @entity0 who died of noncardiac events. Expression of tissue factor, @entity9 factor and tissue factor pathway inhibitor was evaluated by immunohistochemistry. RESULTS: Histopathologically, inflammatory cells infiltrated the endocardium and all seven @entity0 showed features of persistent @entity8 . @entity10 cells [15.3+/-9.4 @entity7 ( @entity7 , mean+/-S.D.) vs. control 2.2+/-4.4/ @entity7 (P=0.0294)] and a few macrophages [5.1+/-8.4 cells/ @entity7 vs. control 2.4+/-3.5 cells/ @entity7 (P=NS)] infiltrated the endocardium. Tissue factor was overexpressed in the endothelia particularly in tissues containing inflammatory cells and denuded matrix of the endocardium, compared with the control group. @entity9 factor, but not tissue factor pathway inhibitor, was also overexpressed in these tissues. CONCLUSION: Tissue factor expression induced by @entity1 is involved in the pathogenesis of @entity4 in @entity0 with @entity5 .

title: Tissue factor expression in atrial endothelia associated with XXXX : possible involvement in intracardiac thrombogenesis.

answer: @entity5


abstract: The long-term effects of sciatic nerve section on @entity1 ( @entity1 ) were studied using dual-energy X-ray absorptiometry (DEXA) in skeletally mature @entity0 . Unilateral sciatic neurectomy caused the rapid loss of cancellous bone in the proximal and distal femur and tibia in the ipsilateral hindlimb and, to a lesser extent, in the contralateral intact hindlimb. The reduction in @entity1 rapidly progressed for 4 weeks after sciatic section and then gradually stabilized with no evidence of recovery at 12 weeks. The development of @entity3 in the contralateral intact hindlimb was a novel finding. There was no evidence of disuse in the normal contralateral hindlimb after unilateral sciatic section; grid-crossing activity over a 24-h interval was unchanged and there was no reduction in weight bearing on the contralateral normal hindpaw during the stance phase of ambulation. Unilateral peripheral nerve lesions have well-documented effects on substance P content and function in the corresponding contralateral intact nerve. We hypothesized that after sciatic section a reduction in substance P signaling might contribute to @entity4 in the contralateral hindlimb. Daily administration of the @entity6 (NK1) antagonist @entity7 for 2 weeks caused significant loss of cancellous bone in the denervated and the contralateral hindlimb, evidence that substance P signaling sustained bone density after nerve section. After sciatic neurectomy there was a 33% reduction in sciatic nerve stimulation-evoked extravasation in the contralateral intact hindlimb, indicating transmedian inhibition of substance P signaling after @entity2 . Furthermore, there was a 50% reduction in the substance P content in both tibias after unilateral sciatic section. Collectively, these data support the hypothesis that a widespread reduction in substance P content in bone contributes to the @entity5 and that residual substance P signaling maintains bone integrity after nerve section in both the denervated and contralateral intact hindlimb.

title: A XXXX (NK1) antagonist enhances the widespread osteoporotic effects of sciatic nerve section.

answer: @entity6


abstract: A 56-year-old @entity0 with persistently elevated liver enzyme levels, fatigue, lethargy and a 9.0 kg weight loss over six months underwent a percutaneous liver biopsy that demonstrated multiple @entity8 . Screening serologies were positive for @entity13 , and he was started on @entity10 treatment. He returned to hospital the same night with coffee-ground emesis and in @entity14 requiring parenteral @entity4 and intensive care unit support. An abdominal computed tomography scan revealed bilaterally enlarged, nonenhancing adrenal glands suggestive of @entity9 , presumed secondary to @entity13 . Treatment was initiated with @entity11 , and @entity12 was cultured from his urine and cerebrospinal fluid. A serum immunodiffusion test was also positive for both @entity15 and M bands, indicating @entity5 with @entity13 species. His serum and urine samples were also weakly positive for the antigen. Despite complications of @entity3 , @entity1 and @entity7 , he recovered with medical therapy and was discharged home to complete a prolonged course of @entity10 therapy. While @entity2 often reflect an occult disease process, the cause may remain undiscovered in 30% to 50% of @entity0 despite exhaustive investigations. @entity12 is an uncommon cause of @entity6 , and with its protean clinical presentation, a high index of suspicion is needed to make the diagnosis and avoid the potentially high fatality rate associated with disseminated @entity5 .

title: A case of @entity12 causing XXXX and @entity14 .

answer: @entity6


abstract: A 56-year-old @entity0 with persistently elevated liver enzyme levels, fatigue, lethargy and a 9.0 kg weight loss over six months underwent a percutaneous liver biopsy that demonstrated multiple @entity8 . Screening serologies were positive for @entity13 , and he was started on @entity10 treatment. He returned to hospital the same night with coffee-ground emesis and in @entity14 requiring parenteral @entity4 and intensive care unit support. An abdominal computed tomography scan revealed bilaterally enlarged, nonenhancing adrenal glands suggestive of @entity9 , presumed secondary to @entity13 . Treatment was initiated with @entity11 , and @entity12 was cultured from his urine and cerebrospinal fluid. A serum immunodiffusion test was also positive for both @entity15 and M bands, indicating @entity5 with @entity13 species. His serum and urine samples were also weakly positive for the antigen. Despite complications of @entity3 , @entity1 and @entity7 , he recovered with medical therapy and was discharged home to complete a prolonged course of @entity10 therapy. While @entity2 often reflect an occult disease process, the cause may remain undiscovered in 30% to 50% of @entity0 despite exhaustive investigations. @entity12 is an uncommon cause of @entity6 , and with its protean clinical presentation, a high index of suspicion is needed to make the diagnosis and avoid the potentially high fatality rate associated with disseminated @entity5 .

title: A case of @entity12 causing @entity6 and XXXX .

answer: @entity14


abstract: A 56-year-old @entity0 with persistently elevated liver enzyme levels, fatigue, lethargy and a 9.0 kg weight loss over six months underwent a percutaneous liver biopsy that demonstrated multiple @entity8 . Screening serologies were positive for @entity13 , and he was started on @entity10 treatment. He returned to hospital the same night with coffee-ground emesis and in @entity14 requiring parenteral @entity4 and intensive care unit support. An abdominal computed tomography scan revealed bilaterally enlarged, nonenhancing adrenal glands suggestive of @entity9 , presumed secondary to @entity13 . Treatment was initiated with @entity11 , and @entity12 was cultured from his urine and cerebrospinal fluid. A serum immunodiffusion test was also positive for both @entity15 and M bands, indicating @entity5 with @entity13 species. His serum and urine samples were also weakly positive for the antigen. Despite complications of @entity3 , @entity1 and @entity7 , he recovered with medical therapy and was discharged home to complete a prolonged course of @entity10 therapy. While @entity2 often reflect an occult disease process, the cause may remain undiscovered in 30% to 50% of @entity0 despite exhaustive investigations. @entity12 is an uncommon cause of @entity6 , and with its protean clinical presentation, a high index of suspicion is needed to make the diagnosis and avoid the potentially high fatality rate associated with disseminated @entity5 .

title: A case of XXXX causing @entity6 and @entity14 .

answer: @entity12


abstract: OBJECTIVE: To investigate the relationship between injury in the marginal division (MrD) of the striatum and the @entity2 . METHODS: Twenty @entity0 with injury in the MrD of the striatum were examined routinely by magnetic resonance imaging (MRI). Cognitive tests of each @entity0 were performed and the results evaluated against their MRI findings. A comparative study of the MRI features and the degree of @entity2 was also performed between these @entity0 and 10 @entity0 with @entity4 ( @entity4 ). RESULTS: @entity1 was the main cause of MrD injuries, manifested by abnormal signals (long T1 and T2 signals) in the MrD. The findings in the 10 @entity4 @entity0 were characterized by atrophy of the temporal lobe, hippocampus and the cortex. The average mini-mental-status examination (MMSE) score of the 20 @entity0 was 19.7, with impaired memory and computation abilities as the main manifestations of @entity2 . The average MMSE score in the @entity4 group was 11, and the @entity2 included all aspects of the cognitive function. No significant difference of the @entity2 was noted between the @entity0 with only injury in the MrD and those with also the injury in other areas of the striatum. CONCLUSION: The MrD is probably a new area related to the memory function of the brain, and the @entity3 may cause @entity2 .

title: [Clinical analysis of the relationship between injury of the marginal division and XXXX ].

answer: @entity2


abstract: Charcot @entity5 is a devastating process that occurs in the @entity0 foot. It must be distinguished from other conditions, such as @entity4 , with efficiency and accuracy. The prognosis and treatment depends on it. Charcot progresses along four radiographically identifiable stages; therefore, plain films should be the first step in the evaluation. When @entity4 is suspected, a three-phase bone scan may allow clear enough anatomic detail to diagnosis bony involvement compared with soft tissue in the forefoot. In the midfoot, a three-phase bone scan alone is not specific enough to distinguish between Charcot and @entity4 . Enhancing the bone scans by adding an additional phase (four-phase) or tracer ( @entity3 ) does not appear to improve specificity significantly. Computerized bone flow studies may be more helpful in making the distinction, particularly in acute presentation. A CT scan is not indicated because the MR image will better define the anatomic extent of the process for preoperative planning. The combined WBC scans and @entity2 colloid marrow scans show improved specificity and can distinguish between Charcot and @entity4 . Combined leukocyte scan with bone marrow imaging is superior to leukocyte and bone scan alone or in combination for detecting @entity1 in the neuropathic foot. The combined leukocyte scan and bone marrow imaging is the current gold standard for evaluating the presence of @entity0 versus @entity5 , and MR imagine is the anatomic gold standard that may be used to define the extent of the process.

title: Imaging modalities of the XXXX foot.

answer: @entity0


abstract: The effect of intracerebroventricular (i.c.v.) perfusion of @entity2 (BBS) on the interdigestive migrating myoelectric complex (MMC) activity was examined in conscious @entity0 with electrodes implanted on the stomach and small intestine. Cannulas and a catheter were chronically positioned in the lateral and fourth cerebral ventricles, respectively. i.c.v. perfusion of BBS, which failed to increase plasma BBS levels, replaced phase I activity in the stomach and duodenum by intense irregular spike activity and decreased the occurrence rate of MMCs, whereas intravenous infusion of BBS evoked phase II-like activity, mainly in the jejunum and ileum, and suppressed phase III activity. These data suggest that the effect of i.c.v. administration of BBS was mediated by direct activation of central brain structures. During i.c.v. perfusion of BBS, cycling in plasma levels of motilin persisted even when phase III activity was absent and plasma levels of @entity1 rose significantly. @entity1 infusion, however, did not affect myoelectric gastrointestinal activity except for prolonging phase II. Thus it is unlikely that the central action of BBS is exerted by motilin or @entity1 .

title: Effect of cerebroventricular perfusion of XXXX on gastrointestinal myoelectric activity.

answer: @entity2


abstract: @entity2 , a 167 @entity1 peptide, is known to influence the gonads via direct and indirect effects. Recent studies provide contradictory proposition about the peripheral impact of @entity2 in the male gonads. Thus, we examined @entity2 and its receptors in @entity0 seminal plasma and in @entity0 ejaculated spermatozoa by Western blot technique and fluorescence microscopy. In seminal plasma we found a free @entity2 band (16 kDa) by an anti- @entity2 polyclonal antibody. Incubation of seminal plasma with recombinant @entity2 caused a statistically significant increase in the amount of free @entity2 (p < 0.01) and supports this finding. Furthermore, a soluble @entity3 (145 kDa) was found in @entity0 seminal plasma in the same specimen. We also detected a 145-kDa @entity3 isoform in ejaculated spermatozoa as a possible target of @entity2 action in the male genital tract, which was localized at the tail of spermatozoa by immunofluorescence microscopy only. This receptor was significantly associated with the intactness of sperm plasma membranes. Spermatozoa with deteriorated membranes contained 49.2 +/- 6.9% @entity3 signal intensity compared with spermatozoa having intact membranes (p < 0.01). This finding is difficult to interpret and may be caused by a leakage of @entity3 due to loss of membrane integrity. In conclusion, these data provide further hints for a peripheral role of @entity2 in the male genital tract, possibly, by an interaction between @entity2 and spermatozoa via sperm @entity2 receptors.

title: Leptin and leptin receptor in XXXX seminal plasma and in @entity0 spermatozoa.

answer: @entity0


abstract: @entity2 , a 167 @entity1 peptide, is known to influence the gonads via direct and indirect effects. Recent studies provide contradictory proposition about the peripheral impact of @entity2 in the male gonads. Thus, we examined @entity2 and its receptors in @entity0 seminal plasma and in @entity0 ejaculated spermatozoa by Western blot technique and fluorescence microscopy. In seminal plasma we found a free @entity2 band (16 kDa) by an anti- @entity2 polyclonal antibody. Incubation of seminal plasma with recombinant @entity2 caused a statistically significant increase in the amount of free @entity2 (p < 0.01) and supports this finding. Furthermore, a soluble @entity3 (145 kDa) was found in @entity0 seminal plasma in the same specimen. We also detected a 145-kDa @entity3 isoform in ejaculated spermatozoa as a possible target of @entity2 action in the male genital tract, which was localized at the tail of spermatozoa by immunofluorescence microscopy only. This receptor was significantly associated with the intactness of sperm plasma membranes. Spermatozoa with deteriorated membranes contained 49.2 +/- 6.9% @entity3 signal intensity compared with spermatozoa having intact membranes (p < 0.01). This finding is difficult to interpret and may be caused by a leakage of @entity3 due to loss of membrane integrity. In conclusion, these data provide further hints for a peripheral role of @entity2 in the male genital tract, possibly, by an interaction between @entity2 and spermatozoa via sperm @entity2 receptors.

title: Leptin and leptin receptor in @entity0 seminal plasma and in XXXX spermatozoa.

answer: @entity0


abstract: AIMS: To undertake a clinicopathological study of @entity16 of epithelial histogenesis which clinically and pathologically mimic @entity11 . METHODS AND RESULTS: Over a 10-year (1990-2000) study period 53 @entity3 mimicking @entity10 ('pseudomesotheliomatous' @entity3 ) were identified. The study group comprised 50 @entity0 and three females, age range 33-77 (median 68) years. In 46 (87%) cases there was a history of smoking and in 40 (76%) cases a history of asbestos exposure. Histologically the @entity3 could be divided into two broad groups: primary @entity1 with florid pleurotropic growth (n = 47), of which 34 (70%) were @entity5 ; and diffuse @entity12 involvement of the pleura by @entity2 (n = 6). This latter group comprised two @entity9 of @entity8 , one ductal @entity6 , one @entity4 and one @entity7 of @entity14 gland origin. Follow-up data were available in 35 cases. @entity2 type, survival was poor (median 8 months) and comparable to @entity10 . CONCLUSIONS: @entity3 are uncommon (comprising 6% of referrals), pathologically heterogeneous @entity2 with poor prognosis. Tissue diagnosis should be obtained in all cases of suspected @entity2 . By light microscopy and immunophenotype many of the @entity2 mimicked @entity11 . In particular, an awareness that all @entity2 exhibiting squamous differentiation may express @entity13 and @entity15 is important to prevent misinterpretation. In this respect, calretinin is regarded as the most specific and sensitive mesothelial marker. Misdiagnosis may have medico-legal implications in asbestos-related compensation claims.

title: 'Pseudomesotheliomatous' XXXX of the pleura: a 10-year analysis of cases from the Environmental Lung Disease Research Group, Cardiff.

answer: @entity3


abstract: The complete sequence of the circular 101,016-bp megaplasmid pKB1 from the @entity6 -degrading bacterium @entity7 Kb1, which represents the first described extrachromosomal DNA of a member of this genus, was determined. Plasmid pKB1 harbors 105 open reading frames. The predicted products of 46 of these are significantly related to proteins of known function. Plasmid pKB1 is organized into three functional regions that are flanked by insertion sequence (IS) elements: (i) a replication and putative partitioning region, (ii) a putative metabolic region, and (iii) a large putative conjugative transfer region, which is interrupted by an additional IS element. Southern hybridization experiments revealed the presence of another copy of this conjugational transfer region on the bacterial chromosome. The origin of replication (oriV) of pKB1 was identified and used for construction of @entity2 -Gordonia shuttle vectors, which was also suitable for several other @entity4 and related genera. The metabolic region included the heavy-metal resistance gene @entity8 , encoding a P-type ATPase. Expression of @entity8 in @entity2 mediated resistance to @entity3 , but not to @entity0 , and decreased the cellular content of @entity3 in this host. When @entity7 Kb1 was cured of plasmid pKB1, the resulting derivative strains exhibited slightly decreased @entity3 resistance. Furthermore, they had lost the ability to use @entity5 rubber as a sole source of @entity1 and energy, suggesting that genes essential for rubber degradation are encoded by pKB1.

title: Characterization of the 101-kilobase-pair megaplasmid pKB1, isolated from the rubber-degrading bacterium XXXX Kb1.

answer: @entity7


abstract: The @entity2 receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as @entity1 , @entity0 , and chronic conditions arising from @entity3 . Previous research suggests that the @entity5 subunit of the receptor contributes to NMDAR excitotoxicity in heterologous cells and in neurons in vivo. To investigate the role of @entity5 in NMDAR excitotoxicity, we have developed a system based on flow cytometry that allows rapid evaluation of the effect of antisense constructs on protein expression and channel function. The enhanced yellow fluorescent protein (EYFP) was fused to obligatory NMDAR subunits, allowing expression to be monitored in living cultured cells. An @entity5 antisense construct, asNR2A, specifically and effectively reduced @entity5 -EYFP expression. @entity4 and @entity5 fusion proteins formed functional, excitotoxic channels upon co-expression. The asNR2A RNA significantly reduced NMDAR excitotoxicity when @entity5 levels were limiting for channel formation. Using our assay system, further optimization can be achieved rapidly. The asNR2A construct and the assays developed for this study can be used to provide insights into NMDAR biology and disease.

title: An antisense construct reduces XXXX receptor 2A expression and receptor-mediated excitotoxicity as determined by a novel flow cytometric approach.

answer: @entity2


abstract: OBJECTIVE: To understand correlates of marital satisfaction in @entity0 with @entity1 ( @entity1 ) and their spouses. METHODS: In a cross-sectional survey, 79 @entity0 with @entity1 and 78 spouses completed the Kansas Marital Satisfaction Scale, the revised Ways of Coping Questionnaire scales, and the Health Assessment Questionnaire. A series of linear regression analyses were then performed to investigate correlates of marital satisfaction for @entity0 and spouses. RESULTS: Seventy-six percent of @entity0 were @entity0 . Mean @entity0 age was 56.5 years (+/- 12.5 years), number of years married was 30.7 (+/- 13.5), and duration of @entity1 was 14.2 years (+/- 9.0 years). Demographic features of spouses resembled those of @entity0 . @entity0 and spouses were generally satisfied with their marriages. Linear regression analyses showed that lower marital satisfaction in @entity0 was associated with higher education level (P < 0.01), @entity0 's greater use of escape into fantasy (P < 0.01), @entity0 's greater use of finding blame (P < 0.05), and spouse's higher use of escape into fantasy (P < 0.001). Spouses less satisfied with their marriages were more likely to use passive acceptance (P < 0.05) and less likely to find blame (P < 0.05). Female spouses were less likely to be satisfied in their marriages (P < 0.01) than male spouses. CONCLUSIONS: This study indicates that certain passive coping styles are associated with lower marital satisfaction in @entity0 with @entity1 and their spouses. More highly educated @entity0 and female spouses are also less satisfied in their marriages. These cross-sectional correlations should not be regarded as causal and should be examined further in longitudinal studies.

title: Marital satisfaction in couples with XXXX .

answer: @entity1


abstract: OBJECTIVE: To explore the roles played by Hispanic ethnic background and acculturation to the mainstream English language culture of the United States in the @entity3 and mental health of @entity4 ( @entity4 ) @entity0 . METHODS: Members of a consecutive cohort of @entity0 with @entity4 were studied cross-sectionally. All underwent a comprehensive clinical and psychosocial evaluation. @entity3 were measured with the Center for Epidemiologic Studies Depression Scale (CES-D), and @entity5 was measured with the Medical Outcomes Study Short Form 36 (SF-36) mental health scale. RESULTS: Two hundred thirty-six @entity0 were studied. @entity0 had significantly higher median CES-D scores than @entity0 (19 versus 14, P = 0.0004), Hispanics scored higher than non-Hispanics (14 versus 8, P = 0.0002), and foreign-born scored higher than US-born @entity0 (14 versus 10, P = 0.009). Compared with those who were fully acculturated, @entity0 who were partially acculturated were more likely to have a score > or = 16 on the @entity4 -adjusted CES-D (odds ratio [OR] = 1.79, 95% confidence interval [95% CI] 1.37 to 2.35, P < or = 0.001). Among unacculturated @entity0 , the likelihood of a score > or = 16 increased 6-fold (OR = 6.68; 95% CI 3.50 to 12.72; P < or = 0.001). A similar, inverse pattern was observed for the SF-36 mental health scale. In multivariate models accounting for age, sex, education, income, @entity2 , @entity1 , and the level of disability, low acculturation was independently associated with high @entity3 , and a Hispanic background was independently associated with lower SF-36 mental health. CONCLUSIONS: In this consecutive series of @entity4 @entity0 , Hispanics, particularly those who are not fully acculturated to the mainstream Anglo society, had more @entity3 and @entity5 than did non-Hispanics.

title: Symptoms of XXXX and @entity5 among Hispanics with @entity4 .

answer: @entity3


abstract: OBJECTIVE: To explore the roles played by Hispanic ethnic background and acculturation to the mainstream English language culture of the United States in the @entity3 and mental health of @entity4 ( @entity4 ) @entity0 . METHODS: Members of a consecutive cohort of @entity0 with @entity4 were studied cross-sectionally. All underwent a comprehensive clinical and psychosocial evaluation. @entity3 were measured with the Center for Epidemiologic Studies Depression Scale (CES-D), and @entity5 was measured with the Medical Outcomes Study Short Form 36 (SF-36) mental health scale. RESULTS: Two hundred thirty-six @entity0 were studied. @entity0 had significantly higher median CES-D scores than @entity0 (19 versus 14, P = 0.0004), Hispanics scored higher than non-Hispanics (14 versus 8, P = 0.0002), and foreign-born scored higher than US-born @entity0 (14 versus 10, P = 0.009). Compared with those who were fully acculturated, @entity0 who were partially acculturated were more likely to have a score > or = 16 on the @entity4 -adjusted CES-D (odds ratio [OR] = 1.79, 95% confidence interval [95% CI] 1.37 to 2.35, P < or = 0.001). Among unacculturated @entity0 , the likelihood of a score > or = 16 increased 6-fold (OR = 6.68; 95% CI 3.50 to 12.72; P < or = 0.001). A similar, inverse pattern was observed for the SF-36 mental health scale. In multivariate models accounting for age, sex, education, income, @entity2 , @entity1 , and the level of disability, low acculturation was independently associated with high @entity3 , and a Hispanic background was independently associated with lower SF-36 mental health. CONCLUSIONS: In this consecutive series of @entity4 @entity0 , Hispanics, particularly those who are not fully acculturated to the mainstream Anglo society, had more @entity3 and @entity5 than did non-Hispanics.

title: Symptoms of @entity3 and XXXX among Hispanics with @entity4 .

answer: @entity5


abstract: OBJECTIVE: To explore the roles played by Hispanic ethnic background and acculturation to the mainstream English language culture of the United States in the @entity3 and mental health of @entity4 ( @entity4 ) @entity0 . METHODS: Members of a consecutive cohort of @entity0 with @entity4 were studied cross-sectionally. All underwent a comprehensive clinical and psychosocial evaluation. @entity3 were measured with the Center for Epidemiologic Studies Depression Scale (CES-D), and @entity5 was measured with the Medical Outcomes Study Short Form 36 (SF-36) mental health scale. RESULTS: Two hundred thirty-six @entity0 were studied. @entity0 had significantly higher median CES-D scores than @entity0 (19 versus 14, P = 0.0004), Hispanics scored higher than non-Hispanics (14 versus 8, P = 0.0002), and foreign-born scored higher than US-born @entity0 (14 versus 10, P = 0.009). Compared with those who were fully acculturated, @entity0 who were partially acculturated were more likely to have a score > or = 16 on the @entity4 -adjusted CES-D (odds ratio [OR] = 1.79, 95% confidence interval [95% CI] 1.37 to 2.35, P < or = 0.001). Among unacculturated @entity0 , the likelihood of a score > or = 16 increased 6-fold (OR = 6.68; 95% CI 3.50 to 12.72; P < or = 0.001). A similar, inverse pattern was observed for the SF-36 mental health scale. In multivariate models accounting for age, sex, education, income, @entity2 , @entity1 , and the level of disability, low acculturation was independently associated with high @entity3 , and a Hispanic background was independently associated with lower SF-36 mental health. CONCLUSIONS: In this consecutive series of @entity4 @entity0 , Hispanics, particularly those who are not fully acculturated to the mainstream Anglo society, had more @entity3 and @entity5 than did non-Hispanics.

title: Symptoms of @entity3 and @entity5 among Hispanics with XXXX .

answer: @entity4


abstract: BACKGROUND AND OBJECTIVES: Approximately one third of all @entity3 @entity0 will experience disease recurrence. Factors that affect @entity0 survival following local, regional, or distant first recurrences of localized @entity3 are the subject of this investigation. METHODS: Survival times for a total of 1,085 first recurrences from 4,568 localized @entity3 @entity0 were examined in relationship to @entity0 and disease factors by Cox regression. Nearly half (48.8%) of all first recurrences were regional, 21.8% were local, and 29.4% were distant recurrences. RESULTS: Survival following recurrence differed significantly by site of recurrence (local, regional, or distant; P < 0.0001). Within each site, the median survival time did not differ by time of recurrence following diagnosis. Significant @entity2 factors for survival following local recurrence included @entity2 thickness (P = 0.0263) and lesion location (P < 0.0001). For regional recurrences, survival was significantly related to @entity4 (P = 0.0105) and whether the recurrence was combined with a local recurrence (P = 0.0429). Survival following distant @entity1 was related to number of distant sites (P < 0.0001) and whether a visceral site was involved (P < 0.0001). CONCLUSIONS: @entity0 and @entity2 characteristics predict survival following recurrence. Regardless of disease-free interval, long-term follow-up of @entity3 @entity0 is necessary. @entity0 experiencing distant @entity1 have the shortest median survival time compared to @entity0 experiencing local or regional recurrences.

title: Factors affecting survival following local, regional, or distant recurrence from localized XXXX .

answer: @entity3


abstract: The aim of the study was to estimate developmental changes in the @entity0 basolateral complex (BLC) by stereological and histochemical methods. Material consisted of 45 brains of @entity0 (aged from 2 to 180 days, P2 to P180) of both sexes, divided into nine groups. The following parameters were estimated: volume of the cerebral hemisphere; volume of the whole BLC and of particular BLC nuclei; neuronal density and total number of neurons in these nuclei. Developmental changes in @entity1 ( @entity1 ) activity in the BLC were also examined. The volume of the cerebral hemisphere increased until P30, whereas volumes of nuclei increased for longer--until P90. The density of neurons in all nuclei studied reached the level characteristic for an adult animal at about P30. The total number of neurons in the dorsolateral division of the lateral nucleus (Ldl) stabilized the earliest--between P30 and P60, whereas in the ventromedial division of the lateral nucleus (Lvm), basomedial (BM) and basolateral (BL) nuclei the number stabilized later--between P60 and P90. @entity1 activity appears minimal in the BLC on P2, reaches a maximum on P30 and then decreases to the level characteristic of an adult animal on P60. @entity1 activity was greater in BL than in other nuclei in all age groups. Reaching adult @entity1 activity 1 month earlier than the total number of neurons in the BLC may indicate a role of the cholinergic system in BLC maturation.

title: Postnatal development of the basolateral complex of XXXX amygdala: a stereological and histochemical study.

answer: @entity0


abstract: The treatment of @entity1 using a distraction procedure as described by Ilizarov is a standard surgical intervention. Nevertheless, there are problems in achieving bony stability in about 10% of cases even after repeated surgery as reported by Lammens et al. (2000). Traub et al. (1999) found a rate of 50% amputations in 33 cases treated since 1927. To prevent an Ilizarov procedure from resulting in a delayed union or nonunion, Paley et al. (1992) recommended autografting immediately after distraction. Based on the good results in the stimulation of osteogenesis in adults, we started to treat delayed bone union following distraction treatment with high-energy shock wave therapy also in @entity0 . In @entity0 suffering from @entity1 with a deviation of the @entity3 , we combine this surgery-substituting therapy with fixation of a Taylor spatial frame in order to correct the @entity2 . Using this new method of treatment, we were able to achieve stability in four @entity0 who previously had had nonunion even after multiple surgical interventions.

title: [3D-navigated high energy shockwave therapy and @entity2 correction after failed distraction treatment of XXXX ].

answer: @entity1


abstract: The treatment of @entity1 using a distraction procedure as described by Ilizarov is a standard surgical intervention. Nevertheless, there are problems in achieving bony stability in about 10% of cases even after repeated surgery as reported by Lammens et al. (2000). Traub et al. (1999) found a rate of 50% amputations in 33 cases treated since 1927. To prevent an Ilizarov procedure from resulting in a delayed union or nonunion, Paley et al. (1992) recommended autografting immediately after distraction. Based on the good results in the stimulation of osteogenesis in adults, we started to treat delayed bone union following distraction treatment with high-energy shock wave therapy also in @entity0 . In @entity0 suffering from @entity1 with a deviation of the @entity3 , we combine this surgery-substituting therapy with fixation of a Taylor spatial frame in order to correct the @entity2 . Using this new method of treatment, we were able to achieve stability in four @entity0 who previously had had nonunion even after multiple surgical interventions.

title: [3D-navigated high energy shockwave therapy and XXXX correction after failed distraction treatment of @entity1 ].

answer: @entity2


abstract: BACKGROUND: The significance of @entity2 volume as an indicator of lymph node @entity1 in advanced @entity3 remains to be clarified. MATERIALS AND METHODS: @entity2 volume was measured from continuous tissue sections taken from 60 @entity0 with advanced @entity3 (34 males and 26 females, aged 35 to 81 years; average 57.3 years) using a computer generated surface rendering method. The @entity2 volume and conventional clinicopathological factors were then analyzed with respect to the prevalence of lymph node @entity1 . RESULTS: Lymph node @entity1 was detected in 26 @entity0 (43%). Of 28 @entity0 with a @entity2 > or = 2000 mm3, lymph node @entity1 was observed in 17 @entity0 (61%): n1, 12 @entity0 ; n2, 3 @entity0 ; n3, 2 @entity0 . Of 32 @entity0 with a @entity2 < 2000 mm3, lymph node @entity1 was observed in 9 @entity0 (28%): n1, 6 @entity0 ; n2, 3 @entity0 . A significant difference was found in the prevalence of lymph node @entity1 between the two groups (p = 0.011). Furthermore, only @entity2 volume was an independent variable associated with lymph node @entity1 according to logistic regression analysis (p = 0.013, odds ratio: 0.253, 95% confidence interval: 0.086-0.747). CONCLUSION: @entity2 volume appears to be an important indicator of lymph node @entity1 in advanced @entity3 . However, this factor cannot be used to introduce the option of limited lymphadenectomy for such @entity0 .

title: @entity2 volume as an indicator of nodal status in advanced XXXX .

answer: @entity3


abstract: BACKGROUND: The significance of @entity2 volume as an indicator of lymph node @entity1 in advanced @entity3 remains to be clarified. MATERIALS AND METHODS: @entity2 volume was measured from continuous tissue sections taken from 60 @entity0 with advanced @entity3 (34 males and 26 females, aged 35 to 81 years; average 57.3 years) using a computer generated surface rendering method. The @entity2 volume and conventional clinicopathological factors were then analyzed with respect to the prevalence of lymph node @entity1 . RESULTS: Lymph node @entity1 was detected in 26 @entity0 (43%). Of 28 @entity0 with a @entity2 > or = 2000 mm3, lymph node @entity1 was observed in 17 @entity0 (61%): n1, 12 @entity0 ; n2, 3 @entity0 ; n3, 2 @entity0 . Of 32 @entity0 with a @entity2 < 2000 mm3, lymph node @entity1 was observed in 9 @entity0 (28%): n1, 6 @entity0 ; n2, 3 @entity0 . A significant difference was found in the prevalence of lymph node @entity1 between the two groups (p = 0.011). Furthermore, only @entity2 volume was an independent variable associated with lymph node @entity1 according to logistic regression analysis (p = 0.013, odds ratio: 0.253, 95% confidence interval: 0.086-0.747). CONCLUSION: @entity2 volume appears to be an important indicator of lymph node @entity1 in advanced @entity3 . However, this factor cannot be used to introduce the option of limited lymphadenectomy for such @entity0 .

title: XXXX volume as an indicator of nodal status in advanced @entity3 .

answer: @entity2


abstract: The availability of a reliable @entity1 model in large animals is important. We report upon our efforts to develop a chronic @entity1 model in seven @entity5 using sequential ligation of the @entity6 ( @entity6 ) coronary artery and its diagonal branch. After anesthesia and left thoracotomy, the @entity6 artery was ligated, and the diagonal vessel at the same level was ligated one hour later. Cardiac measurements were performed with a thermodilution catheter and by ultrasonography. Two months after the operation, the same measurements were made and animals were sacrificed for postmortem examinations of their hearts. Hemodynamic measurements, except cardiac output, showed no significant changes immediately after the coronary artery ligation. Echocardiographic measurements showed significant changes in the ejection fraction and fractional shortening without changes in left ventricular dimensions. Wall motion analyses demonstrated variable degrees of anteroseptal @entity3 and @entity3 in all animals immediately after coronary artery ligation. Five animals have undergone hemodynamic and ultrasonographic studies 2 months after coronary artery ligation. The results obtained from these animals showed significant increases in central venous pressure, right ventricular pressure, pulmonary artery pressure, and pulmonary artery capillary wedge pressure, and a significant decrease in cardiac output. Increases in left ventricular dimensions and decreases in ejection fraction with fractional shortening in ultrasonographic studies were also observed. Pathologically, well-demarcated thin-walled anteroseptal @entity4 , with chamber enlargement, were clearly seen with dilatation of the @entity0 in all specimens. Based on this study, we conclude that @entity5 , like @entity2 , can provide a reliable model of chronic @entity1 by coronary artery ligation and in view of the many advantages offered by @entity5 , we believe that this animal model will be useful for cardiac experimentation.

title: A chronic XXXX model by coronary artery ligation in the @entity5 .

answer: @entity1


abstract: The availability of a reliable @entity1 model in large animals is important. We report upon our efforts to develop a chronic @entity1 model in seven @entity5 using sequential ligation of the @entity6 ( @entity6 ) coronary artery and its diagonal branch. After anesthesia and left thoracotomy, the @entity6 artery was ligated, and the diagonal vessel at the same level was ligated one hour later. Cardiac measurements were performed with a thermodilution catheter and by ultrasonography. Two months after the operation, the same measurements were made and animals were sacrificed for postmortem examinations of their hearts. Hemodynamic measurements, except cardiac output, showed no significant changes immediately after the coronary artery ligation. Echocardiographic measurements showed significant changes in the ejection fraction and fractional shortening without changes in left ventricular dimensions. Wall motion analyses demonstrated variable degrees of anteroseptal @entity3 and @entity3 in all animals immediately after coronary artery ligation. Five animals have undergone hemodynamic and ultrasonographic studies 2 months after coronary artery ligation. The results obtained from these animals showed significant increases in central venous pressure, right ventricular pressure, pulmonary artery pressure, and pulmonary artery capillary wedge pressure, and a significant decrease in cardiac output. Increases in left ventricular dimensions and decreases in ejection fraction with fractional shortening in ultrasonographic studies were also observed. Pathologically, well-demarcated thin-walled anteroseptal @entity4 , with chamber enlargement, were clearly seen with dilatation of the @entity0 in all specimens. Based on this study, we conclude that @entity5 , like @entity2 , can provide a reliable model of chronic @entity1 by coronary artery ligation and in view of the many advantages offered by @entity5 , we believe that this animal model will be useful for cardiac experimentation.

title: A chronic @entity1 model by coronary artery ligation in the XXXX .

answer: @entity5


abstract: Increasingly, there is the need to analyze gene expression in @entity0 tissues and correlate these findings with clinical outcome. Because there are few tissue banks containing enough frozen material suitable for large-scale genetic analyses, methods to isolate and quantify messenger RNA (mRNA) from @entity2 -fixed, @entity5 -embedded tissue sections are needed. Recovery of RNA from routinely processed biopsies and quantification by the polymerase chain reaction (PCR) has been reported; however, the effects of @entity2 fixation have not been well studied. We used a proteinase K-salt precipitation RNA isolation protocol followed by TaqMan quantitative PCR to compare the effect of @entity2 fixation for 24, 48, and 72 hours and for 1 week in normal (2), @entity7 (3), and @entity4 (4) specimens yielding 9 fresh and 36 @entity2 -fixed samples. We also compared mRNA and protein expression levels using immunohistochemistry for @entity3 ( @entity3 ), @entity8 , @entity9 , and @entity1 ( @entity1 ) in 15 randomly selected and routinely processed @entity6 . We were able to extract RNA suitable for quantitative @entity10 ( @entity10 ) from all fresh (9/9) and @entity2 -fixed (36/36) specimens fixed for differing lengths of time and from all (15/15) randomly selected @entity4 . We found that prolonged @entity2 fixation (>48 h) had a detrimental effect on quantitative @entity10 polymerase chain reaction results that was most marked for @entity8 and @entity1 but less evident for @entity9 and @entity3 . Comparisons of quantitative @entity10 polymerase chain reaction and immunohistochemistry showed that for all markers, except @entity9 , there was good correlation between mRNA and protein levels. @entity9 mRNA was overexpressed in only one case, but protein levels were elevated in all but one @entity0 , consistent with the established translational regulation of @entity9 . These results show that RNA can be reliably isolated from @entity2 -fixed, @entity5 -embedded tissue sections and can produce reliable quantitative @entity10 -PCR data. However, results for some markers are adversely affected by prolonged @entity2 fixation times.

title: Effect of duration of fixation on quantitative XXXX polymerase chain reaction analyses.

answer: @entity10


abstract: OBJECTIVE: The aim of this prospective, controlled study was to evaluate the risk factors for @entity4 in @entity0 undergoing gynecologic surgery and receiving @entity0 -controlled analgesia for three days. METHODS: Six hundred twenty-five gynecologic @entity0 with an American Society of Anesthesiologists physical status of I to III undergoing lower-abdominal surgeries were enrolled. A standard, general anesthetic technique was used. @entity2 was treated by a @entity0 -controlled analgesia device with bolus intravenous doses of 1 mg @entity5 . For 3 days after surgery @entity0 were assessed for occurrence of @entity3 , sedation, and @entity1 intensity when at rest and during movement. RESULTS: The incidence of @entity3 was 26% on postoperative day 1, 13% on day 2, and 4% on day 3. On all 3 days, @entity0 ' @entity1 scores when at rest and when coughing were higher for those with @entity3 than for those without. During the first 2 postoperative days the @entity0 with and those without @entity3 consumed similar amounts of @entity5 daily, but on the third day the @entity0 with @entity3 consumed significantly more @entity5 than did those without @entity3 ( <0.05). Further logistic regression analysis showed that incident @entity1 was the main risk factor for @entity4 on all 3 days. CONCLUSIONS: The results suggested that @entity2 was an associative risk factor to increase the incidence of @entity3 in these female @entity0 .

title: Does @entity2 induce XXXX ?

answer: @entity3