abstract: OBJECTIVES: (1) To explain general practitioners' (GPs') approaches to @entity2 ( @entity2 ) testing and overdiagnosis; (2) to explain how GPs reason about their @entity2 testing routines and (3) to explain how these routines influence GPs' personal experience as clinicians. SETTING: Primary care practices in Australia including @entity0 's health clinics and rural practices with variable access to urology services. @entity0 : 32 urban and rural GPs within Australia. We included GPs of varying ages, gender (11 female), clinical experience and @entity0 populations. All GPs interested in participating in the study were included. PRIMARY AND SECONDARY OUTCOME MEASURES: Data were analysed using grounded theory methods to determine how and why GPs provide (or do not provide) @entity2 testing to their asymptomatic male @entity0 . RESULTS: We observed patterned variation in GP practice, and identified four heuristics to describe GP preference for, and approaches to, @entity2 testing and overdiagnosis: (1) GPs who prioritised avoiding underdiagnosis, (2) GPs who weighed underdiagnosis and overdiagnosis case by case, (3) GPs who prioritised avoiding overdiagnosis and (4) GPs who did not engage with overdiagnosis at all. The heuristics guided GPs' Routine Practice (usual testing, communication and responses to @entity0 request). The heuristics also reflected GPs' different Practice Rationales (drawing on experience, medicolegal obligations, guidelines and evidence) and produced different Practice Outcomes (GPs' experiences of the consequences of their @entity2 testing decisions). Some of these heuristics were more responsive to @entity0 preferences than others. CONCLUSIONS: Variation in GPs' @entity2 testing practices is strongly related to their approach to overdiagnosis and underdiagnosis of @entity1 . @entity0 receive very different care depending on their GP's reasoning and practice preferences. Future policy to address overdiagnosis will be more likely to succeed if it responds to these patterned variations.

title: Doctors' approaches to XXXX testing and overdiagnosis in primary healthcare: a qualitative study.

answer: @entity2


abstract: Studying sleep behavior in animal models demands clear separation of vigilance states. Pure manual scoring is time-consuming and commercial scoring software is costly. We present a LabVIEW-based, semi-automated scoring routine using recorded EEG and EMG signals. This scoring routine is    designed to reliably assign the vigilance/sleep states @entity1 ( @entity1 ), @entity3 ( @entity3 ) and rapid eye @entity2 (REMS) to defined EEG/EMG episodes.   straightforward to use even for beginners in the field of sleep research.   freely available upon request. Chronic recordings from @entity0 were used to design and evaluate the scoring routine consisting of an artifact-removal, a scoring- and a rescoring routine. The scoring routine processes EMG and different EEG frequency bands. Amplitude-based thresholds for EEG and EMG parameters trigger a decision tree assigning each EEG episode to a defined vigilance/sleep state automatically. Using the rescoring routine individual episodes or particular state transitions can be re-evaluated manually. High agreements between auto-scored and manual sleep scoring could be shown for experienced scorers and for beginners quickly and reliably. With small modifications to the software, it can be easily adapted for sleep analysis in other animal models.

title: Sleep scoring made easy-Semi-automated sleep analysis software and manual rescoring tools for basic sleep research in XXXX .

answer: @entity0


abstract: BACKGROUND: Little is known about the long-term outcomes of catheter ablation of @entity4 ( @entity4 ) using @entity1 ( @entity1 ). METHODS: One hundred twenty @entity0 underwent catheter ablation of SVTs with @entity1 (Niobe, Stereotaxis, USA): atrioventricular nodal re-entrant @entity2 (AVNRT; n   =   59), @entity2 ( @entity2 ; n   =   45), and focal @entity2 ( @entity2 , n   =   16). The outcome of @entity2 with right free wall accessory pathway was compared with those of a group of 26 consecutive @entity0 undergoing manual ablation. RESULTS: Mean follow-up period was 2.2        1.4  years. Overall @entity3 -free survival was 86  %; @entity2 (77  %), AVNRT (96  %), and focal @entity2 (71  %). After the learning period (initial 50 cases), procedural outcomes had improved for @entity2 and AVNRT (91  % in overall group, 90  % in @entity2 group, 100  % in AVNRT group, and 68  % in focal @entity2 group). The recurrence-free rate was higher for the free wall accessory pathways than those of the other sites (92 vs. 73  %, log-rank P   =   0.06). Furthermore, when it is confined for the right free wall accessory pathway, @entity1 showed excellent long-term outcome (7/7, 100  %) compared to the results of manual approach (18/26, 69.2  %, log-rank P   =   0.07). CONCLUSIONS: @entity1 showed favorable long-term outcomes for the ablation of @entity4 . In our experience, @entity1 -guided ablation may be associated with a higher success rate as compared to manual ablation when treating right-sided free wall pathways.

title: Long-term outcomes of remote magnetic navigation for ablation of XXXX .

answer: @entity4


abstract: OBJECTIVES: Periorbital microcystic @entity2 ( @entity2 ) can cause severe symptoms, such as @entity5 , @entity8 , chemosis, strabismus, @entity7 , and @entity6 . The purpose of this study was to evaluate the clinical outcome in periorbital microcystic @entity2 @entity0 with @entity5 who underwent surgical treatment combined with intralesional @entity4 injection. @entity0 AND METHODS: A retrospective study including nine @entity0 diagnosed as periorbital microcystic @entity2 with @entity5 was conducted. All of the @entity0 underwent surgical treatment and @entity4 injection from January 2010 to January 2014. The lesion was resected through the lower eyebrow and/or a coronal incision at the first stage, and levator resection was performed at the second stage. Any persistent lesion or its recurrence was managed by intralesional @entity4 injection. RESULTS: @entity5 and @entity1 were corrected in all @entity0 . Mean follow-up was 24.6months. Six @entity0 had recurrence during the follow-up, and two @entity0 who had partial eyelid closure after the second stage surgery recovered in three months. @entity8 , @entity3 , and strabismus were not improved after treatment. All of the @entity0 had excellent aesthetic improvement and corrected @entity5 . CONCLUSIONS: Resection through a lower eyebrow and coronal incision and levator resection performed in two stages can quickly correct the @entity1 caused by periorbital microcystic @entity2 with @entity5 . Intralesional @entity4 injection is a promising adjunctive therapy for residual or recurrent lesions after surgery.

title: Management of periorbital microcystic @entity2 with @entity5 : Surgical treatment combined with intralesional XXXX injection.

answer: @entity4


abstract: OBJECTIVES: Periorbital microcystic @entity2 ( @entity2 ) can cause severe symptoms, such as @entity5 , @entity8 , chemosis, strabismus, @entity7 , and @entity6 . The purpose of this study was to evaluate the clinical outcome in periorbital microcystic @entity2 @entity0 with @entity5 who underwent surgical treatment combined with intralesional @entity4 injection. @entity0 AND METHODS: A retrospective study including nine @entity0 diagnosed as periorbital microcystic @entity2 with @entity5 was conducted. All of the @entity0 underwent surgical treatment and @entity4 injection from January 2010 to January 2014. The lesion was resected through the lower eyebrow and/or a coronal incision at the first stage, and levator resection was performed at the second stage. Any persistent lesion or its recurrence was managed by intralesional @entity4 injection. RESULTS: @entity5 and @entity1 were corrected in all @entity0 . Mean follow-up was 24.6months. Six @entity0 had recurrence during the follow-up, and two @entity0 who had partial eyelid closure after the second stage surgery recovered in three months. @entity8 , @entity3 , and strabismus were not improved after treatment. All of the @entity0 had excellent aesthetic improvement and corrected @entity5 . CONCLUSIONS: Resection through a lower eyebrow and coronal incision and levator resection performed in two stages can quickly correct the @entity1 caused by periorbital microcystic @entity2 with @entity5 . Intralesional @entity4 injection is a promising adjunctive therapy for residual or recurrent lesions after surgery.

title: Management of periorbital microcystic XXXX with @entity5 : Surgical treatment combined with intralesional @entity4 injection.

answer: @entity2


abstract: OBJECTIVES: Periorbital microcystic @entity2 ( @entity2 ) can cause severe symptoms, such as @entity5 , @entity8 , chemosis, strabismus, @entity7 , and @entity6 . The purpose of this study was to evaluate the clinical outcome in periorbital microcystic @entity2 @entity0 with @entity5 who underwent surgical treatment combined with intralesional @entity4 injection. @entity0 AND METHODS: A retrospective study including nine @entity0 diagnosed as periorbital microcystic @entity2 with @entity5 was conducted. All of the @entity0 underwent surgical treatment and @entity4 injection from January 2010 to January 2014. The lesion was resected through the lower eyebrow and/or a coronal incision at the first stage, and levator resection was performed at the second stage. Any persistent lesion or its recurrence was managed by intralesional @entity4 injection. RESULTS: @entity5 and @entity1 were corrected in all @entity0 . Mean follow-up was 24.6months. Six @entity0 had recurrence during the follow-up, and two @entity0 who had partial eyelid closure after the second stage surgery recovered in three months. @entity8 , @entity3 , and strabismus were not improved after treatment. All of the @entity0 had excellent aesthetic improvement and corrected @entity5 . CONCLUSIONS: Resection through a lower eyebrow and coronal incision and levator resection performed in two stages can quickly correct the @entity1 caused by periorbital microcystic @entity2 with @entity5 . Intralesional @entity4 injection is a promising adjunctive therapy for residual or recurrent lesions after surgery.

title: Management of periorbital microcystic @entity2 with XXXX : Surgical treatment combined with intralesional @entity4 injection.

answer: @entity5


abstract: BACKGROUND/PURPOSE: @entity0 with @entity2 ( @entity2 ) undergoing umbilical cord blood transplantation (UCBT) who are at risk for post-transplant failure to thrive may benefit from pretransplant @entity3 ( @entity3 ) placement. Here we sought to determine predictors of posttransplant failure to thrive. METHODS: A retrospective analysis was performed for IMD @entity0 who underwent UCBT at a single center from 2001 to 2011. @entity0 who received GTs were compared with controls. Multivariable logistic regression was used to determine significant predictors for @entity3 placement. Recursive partitioning was performed to determine appropriate cut-offs for significant continuous variables. RESULTS: Two hundred and seventeen @entity0 met inclusion criteria of which twenty-three were excluded due to @entity1 within one hundred days of transplant. Forty (20.6%) of the remaining @entity0 underwent a surgical @entity3 placement. Multivariable logistic regression demonstrated that weight percentile at time of transplant was significantly associated with @entity3 placement (Adjusted odds ratio (AOR): 0.87 per 10th percentile, p=0.022). Recursive partitioning demonstrated that the 40th weight percentile at time of transplant was an optimal cut-off for predicting @entity3 placement. CONCLUSIONS: @entity0 preparing for umbilical cord transplantation who are below the 40th percentile for weight may benefit from pre-emptive @entity3 placement prior to transplant.

title: Predictors of gastrostomy placement in @entity0 with XXXX treated by umbilical cord blood transplantation.

answer: @entity2


abstract: BACKGROUND/PURPOSE: @entity0 with @entity2 ( @entity2 ) undergoing umbilical cord blood transplantation (UCBT) who are at risk for post-transplant failure to thrive may benefit from pretransplant @entity3 ( @entity3 ) placement. Here we sought to determine predictors of posttransplant failure to thrive. METHODS: A retrospective analysis was performed for IMD @entity0 who underwent UCBT at a single center from 2001 to 2011. @entity0 who received GTs were compared with controls. Multivariable logistic regression was used to determine significant predictors for @entity3 placement. Recursive partitioning was performed to determine appropriate cut-offs for significant continuous variables. RESULTS: Two hundred and seventeen @entity0 met inclusion criteria of which twenty-three were excluded due to @entity1 within one hundred days of transplant. Forty (20.6%) of the remaining @entity0 underwent a surgical @entity3 placement. Multivariable logistic regression demonstrated that weight percentile at time of transplant was significantly associated with @entity3 placement (Adjusted odds ratio (AOR): 0.87 per 10th percentile, p=0.022). Recursive partitioning demonstrated that the 40th weight percentile at time of transplant was an optimal cut-off for predicting @entity3 placement. CONCLUSIONS: @entity0 preparing for umbilical cord transplantation who are below the 40th percentile for weight may benefit from pre-emptive @entity3 placement prior to transplant.

title: Predictors of gastrostomy placement in XXXX with @entity2 treated by umbilical cord blood transplantation.

answer: @entity0


abstract: BACKGROUND: A healthy Nordic dietary pattern has shown beneficial effects in relation to several @entity3 . However, no study has evaluated the association between a healthy Nordic food index (HNFI) and risk of @entity0 . METHODS: We conducted a prospective cohort study including 44,296 @entity1 , aged 29-49 at baseline in 1991-1992, who completed a food frequency questionnaire at baseline, and have been followed up ever since, through the Swedish @entity2 Registry and Cause of Death Registry. Each @entity1 was assigned a HNFI score ranging from 0 to 6. We calculated multivariable relative risks (RRs) and 95  % confidence intervals (CIs) using Poisson regression models with attained age as the underlying timescale. The association between the HNFI and risk of @entity0 was assessed both overall, by menopausal status and by hormone receptor status. RESULTS: A total of 1,464 @entity0 cases were diagnosed during a median follow-up time of 20  years. A higher adherence to the HNFI was not associated with a lower risk of @entity0 overall, nor of varied hormone receptor status, or when we examining premenopausal and postmenopausal @entity1 separately. The multivariable RRs (95  % CI) for @entity0 per 1-point increment in the HNFI were 1.02 (95  % CI 0.98-1.06) for all @entity1 , 1.01 (95  % CI 0.95-1.08) for premenopausal @entity1 , and 1.02 (95  % CI 0.97-1.07) for postmenopausal @entity1 . CONCLUSION: Adherence to a HNFI was not associated with @entity0 incidence in this cohort of relatively young @entity1 , regardless of menopausal status or hormone receptor status.

title: Adherence to a healthy Nordic food index and XXXX risk: results from a Swedish cohort study.

answer: @entity0


abstract: BACKGROUND: Major life-threatening complications secondary to cisplatin-based chemotherapy are rare in @entity0 with @entity1 ( @entity1 ). The incidence of complications increases with dosage of chemotherapy and with a variety of @entity0 -related as well as disease-related conditions. We here report the first case of @entity1 experiencing as many as four major complications most of which can be explained by the conjunction of several predispositions. CASE PRESENTATION: A 48  year old @entity0 with @entity10 and bulky retroperitoneal and mediastinal metastases underwent cisplatin based chemotherapy. During the third cycle of chemotherapy, he developed @entity7 of the central venous port device, subtotal @entity8 , and Bleomycin induced @entity4 (BIP). Three months after completion of therapy, he was struck by @entity8 . Genetic testing then revealed heterozygote mutation of @entity11 ( @entity11 ). He received full-dose warfarin anticoagulation treatment and steroid treatment for BIP. 18  months thereafter, the @entity0 is still disease-free, oncologically. @entity2 have disappeared, but @entity5 persists with a vital capacity of 50%. CONCLUSION: The unique co-incidence of four major complications occurring in this @entity0 were obviously triggered by the genetically determined predisposition of the @entity0 to @entity7 events ( @entity11 ). Additionally, several @entity0 -related and disease-related conditions contributed to the unique pattern of complications, i.e. (1) the slightly advanced age (48  years), (2) the @entity6 caused by the disease of @entity1 , (3) the central venous port device, (4) retroperitoneal bulky metastasis, and (5) cisplatin chemotherapy. Whether or not @entity11 contributed to the @entity9 as well, remains elusive. Practically, in the case of one major vascular complication during cisplatin chemotherapy at standard dose, genetic testing for hereditary @entity3 should be considered. Thus, precautions for preventing further complications could be initiated.

title: XXXX mutation triggering four major complications to standard dose cisplatin-chemotherapy for @entity10 : a case report.

answer: @entity11


abstract: BACKGROUND: Major life-threatening complications secondary to cisplatin-based chemotherapy are rare in @entity0 with @entity1 ( @entity1 ). The incidence of complications increases with dosage of chemotherapy and with a variety of @entity0 -related as well as disease-related conditions. We here report the first case of @entity1 experiencing as many as four major complications most of which can be explained by the conjunction of several predispositions. CASE PRESENTATION: A 48  year old @entity0 with @entity10 and bulky retroperitoneal and mediastinal metastases underwent cisplatin based chemotherapy. During the third cycle of chemotherapy, he developed @entity7 of the central venous port device, subtotal @entity8 , and Bleomycin induced @entity4 (BIP). Three months after completion of therapy, he was struck by @entity8 . Genetic testing then revealed heterozygote mutation of @entity11 ( @entity11 ). He received full-dose warfarin anticoagulation treatment and steroid treatment for BIP. 18  months thereafter, the @entity0 is still disease-free, oncologically. @entity2 have disappeared, but @entity5 persists with a vital capacity of 50%. CONCLUSION: The unique co-incidence of four major complications occurring in this @entity0 were obviously triggered by the genetically determined predisposition of the @entity0 to @entity7 events ( @entity11 ). Additionally, several @entity0 -related and disease-related conditions contributed to the unique pattern of complications, i.e. (1) the slightly advanced age (48  years), (2) the @entity6 caused by the disease of @entity1 , (3) the central venous port device, (4) retroperitoneal bulky metastasis, and (5) cisplatin chemotherapy. Whether or not @entity11 contributed to the @entity9 as well, remains elusive. Practically, in the case of one major vascular complication during cisplatin chemotherapy at standard dose, genetic testing for hereditary @entity3 should be considered. Thus, precautions for preventing further complications could be initiated.

title: @entity11 mutation triggering four major complications to standard dose cisplatin-chemotherapy for XXXX : a case report.

answer: @entity10


abstract: PURPOSE: The aim of this study was to compare multidetector CT (MDCT), MRI, and FDG PET/CT imaging for the @entity3 ( @entity3 ) in @entity2 . @entity0 AND METHODS: Fifteen @entity0 with @entity2 and suspected @entity3 underwent MDCT, MRI, and FDG PET/CT, shortly before surgery. Nine abdominopelvic regions were defined according to the peritoneal @entity1 index. We applied lesion size scores on MDCT and MR and measured FDG PET/CT standard uptake. We blindly read MDCT, MR, and PET/CT before joint review and comparison with histopathology. Receiver operating characteristics analysis was performed. RESULTS: Ten @entity0 had @entity3 (67%). Altogether, 135 abdominopelvic sites were compared. Multidetector CT, MRI, and FDG PET/CT had a sensitivity of 96%, 98%, and 95%, and specificity was 92%, 84%, and 96%, respectively. Corresponding receiver operating characteristics area was 0.94, 0.90, and 0.96, respectively, without any significant differences between them (P = 0.12). FDG PET/CT detected supradiaphragmatic disease in 3 @entity0 (20%) not seen by MDCT or MRI. CONCLUSIONS: Although MRI had the highest sensitivity and FDG PET/CT had the highest specificity, no significant differences were found between the 3 techniques. Thus, MDCT, as the fastest, most economical, and most widely available modality, is the examination of choice, if a stand-alone technique is required. If inconclusive, PET/CT or MRI may offer additional insights. Whole-body FDG PET/CT may be more accurate for supradiaphragmatic metastatic extension.

title: XXXX in Primary @entity2 : Comparison Between MDCT, MRI, and 18F-FDG PET/CT.

answer: @entity3


abstract: PURPOSE: The aim of this study was to compare multidetector CT (MDCT), MRI, and FDG PET/CT imaging for the @entity3 ( @entity3 ) in @entity2 . @entity0 AND METHODS: Fifteen @entity0 with @entity2 and suspected @entity3 underwent MDCT, MRI, and FDG PET/CT, shortly before surgery. Nine abdominopelvic regions were defined according to the peritoneal @entity1 index. We applied lesion size scores on MDCT and MR and measured FDG PET/CT standard uptake. We blindly read MDCT, MR, and PET/CT before joint review and comparison with histopathology. Receiver operating characteristics analysis was performed. RESULTS: Ten @entity0 had @entity3 (67%). Altogether, 135 abdominopelvic sites were compared. Multidetector CT, MRI, and FDG PET/CT had a sensitivity of 96%, 98%, and 95%, and specificity was 92%, 84%, and 96%, respectively. Corresponding receiver operating characteristics area was 0.94, 0.90, and 0.96, respectively, without any significant differences between them (P = 0.12). FDG PET/CT detected supradiaphragmatic disease in 3 @entity0 (20%) not seen by MDCT or MRI. CONCLUSIONS: Although MRI had the highest sensitivity and FDG PET/CT had the highest specificity, no significant differences were found between the 3 techniques. Thus, MDCT, as the fastest, most economical, and most widely available modality, is the examination of choice, if a stand-alone technique is required. If inconclusive, PET/CT or MRI may offer additional insights. Whole-body FDG PET/CT may be more accurate for supradiaphragmatic metastatic extension.

title: @entity3 in Primary XXXX : Comparison Between MDCT, MRI, and 18F-FDG PET/CT.

answer: @entity2


abstract: UNASSIGNED: Intimate partner violence (IPV) is a worldwide health concern and an important risk factor for poor mental/physical health in both @entity0 and @entity0 . Little is known about whether IPV leads to @entity1 . However, sleep problems may be common in the context of IPV and may mediate relationships with mental/physical health. Data from the 2006 Behavioral Risk Factor Surveillance System (BRFSS) were used (N = 34,975). IPV was assessed in female and male @entity0 for any history of being threatened by, physically hurt by, or forced to have sex with an intimate partner (THREAT, HURT, and SEX, respectively), and, further, as being forced to have sex with or physically injured by an intimate partner within the past year (SEXyr and HURTyr, respectively). These survey items were coded yes/no. @entity1 was assessed as @entity2 , staying asleep, or sleeping too much at least 6 of the last 14 days. Logistic regression analyses, adjusted for age, sex, race, income, education, and physical/mental health, assessed whether IPV predicted @entity1 . Sobel-Goodman tests assessed whether relationships between IPV and physical/mental health were partially mediated by @entity1 . All IPV variables were associated with @entity1 , even after adjusting for the effects of age, sex, race/ethnicity, income, education, employment, marital status, physical health and mental health. THREAT was associated with @entity1 (odds ratio [OR] = 2.798, p < .0001), as was HURT (OR = 2.683, p < .0001), SEX (OR = 3.237, p < .0001), SEXyr (OR = 7.741, p < .0001), and HURTyr (OR = 7.497, p < .0001). In mediation analyses, all IPV variables were associated with mental health (p < .0001), and all were associated with physical health (p < .007) except SEXyr. @entity1 partially mediated all relationships (Sobel p < .0005 for all tests). Mediation was around 30%, ranging from 18% (HURTyr and mental health) to 41% (HURT and physical health). IPV was strongly associated with current @entity1 above the effect of demographics and overall mental/physical health, even if the IPV happened in the past. Furthermore, @entity1 partially mediates the relationship between IPV and mental/physical health. Sleep interventions may potentially mitigate negative effects of IPV.

title: Sleep Disturbance Partially Mediates the Relationship Between Intimate Partner Violence and Physical/Mental Health in XXXX and @entity0 .

answer: @entity0


abstract: UNASSIGNED: Intimate partner violence (IPV) is a worldwide health concern and an important risk factor for poor mental/physical health in both @entity0 and @entity0 . Little is known about whether IPV leads to @entity1 . However, sleep problems may be common in the context of IPV and may mediate relationships with mental/physical health. Data from the 2006 Behavioral Risk Factor Surveillance System (BRFSS) were used (N = 34,975). IPV was assessed in female and male @entity0 for any history of being threatened by, physically hurt by, or forced to have sex with an intimate partner (THREAT, HURT, and SEX, respectively), and, further, as being forced to have sex with or physically injured by an intimate partner within the past year (SEXyr and HURTyr, respectively). These survey items were coded yes/no. @entity1 was assessed as @entity2 , staying asleep, or sleeping too much at least 6 of the last 14 days. Logistic regression analyses, adjusted for age, sex, race, income, education, and physical/mental health, assessed whether IPV predicted @entity1 . Sobel-Goodman tests assessed whether relationships between IPV and physical/mental health were partially mediated by @entity1 . All IPV variables were associated with @entity1 , even after adjusting for the effects of age, sex, race/ethnicity, income, education, employment, marital status, physical health and mental health. THREAT was associated with @entity1 (odds ratio [OR] = 2.798, p < .0001), as was HURT (OR = 2.683, p < .0001), SEX (OR = 3.237, p < .0001), SEXyr (OR = 7.741, p < .0001), and HURTyr (OR = 7.497, p < .0001). In mediation analyses, all IPV variables were associated with mental health (p < .0001), and all were associated with physical health (p < .007) except SEXyr. @entity1 partially mediated all relationships (Sobel p < .0005 for all tests). Mediation was around 30%, ranging from 18% (HURTyr and mental health) to 41% (HURT and physical health). IPV was strongly associated with current @entity1 above the effect of demographics and overall mental/physical health, even if the IPV happened in the past. Furthermore, @entity1 partially mediates the relationship between IPV and mental/physical health. Sleep interventions may potentially mitigate negative effects of IPV.

title: Sleep Disturbance Partially Mediates the Relationship Between Intimate Partner Violence and Physical/Mental Health in @entity0 and XXXX .

answer: @entity0


abstract: OBJECTIVE AND DESIGN: Adipose tissue macrophages (ATMs) have been implicated in a number of @entity2 . Because the activated macrophages associated with many types of autoimmune and inflammatory diseases express a @entity3 receptor (FR) that can be exploited for FR-targeted drug delivery, we examined the visceral adipose tissue of @entity2 @entity1 and @entity0 to determine whether ATMs also express FR that are accessible by @entity3 conjugates. MATERIAL OR SUBJECTS: C57BL/6 or FATSO @entity1 fed on either a low- or high-fat diet were used in @entity1 studies. @entity0 adipose tissue were obtained from healthy volunteers during adipose reduction surgery. METHODS: Visceral adipose tissue was collected from both @entity2 @entity1 and @entity0 , collagenase digested, and stained with @entity3 -Oregon Green and antibodies for macrophage markers including F4/80, @entity5 receptor ( @entity7 ), @entity6 , and @entity4 . Cells were then examined for expression of the above markers by flow cytometry. Furthermore, the ability of @entity3 conjugates to target the FR-expressing ATMs in @entity2 @entity1 was evaluated in vivo. RESULTS: A subset of the ATMs harvested from @entity2 @entity1 were found to express FR. Subpopulations of ATMs also simultaneously express both pro- and anti-inflammatory markers, and FR is expressed on both subsets. We then demonstrate that FR-expressing ATMs can be targeted with @entity3 -linked fluorescent dyes in vivo. CONCLUSIONS: FR are expressed on multiple subsets of ATMs and these subsets can be targeted with @entity3 -linked drugs, allowing for the possible development of FR-targeted therapies for @entity2 -related inflammatory diseases.

title: XXXX receptor expression on @entity1 and @entity0 adipose tissue macrophages.

answer: @entity3


abstract: OBJECTIVE AND DESIGN: Adipose tissue macrophages (ATMs) have been implicated in a number of @entity2 . Because the activated macrophages associated with many types of autoimmune and inflammatory diseases express a @entity3 receptor (FR) that can be exploited for FR-targeted drug delivery, we examined the visceral adipose tissue of @entity2 @entity1 and @entity0 to determine whether ATMs also express FR that are accessible by @entity3 conjugates. MATERIAL OR SUBJECTS: C57BL/6 or FATSO @entity1 fed on either a low- or high-fat diet were used in @entity1 studies. @entity0 adipose tissue were obtained from healthy volunteers during adipose reduction surgery. METHODS: Visceral adipose tissue was collected from both @entity2 @entity1 and @entity0 , collagenase digested, and stained with @entity3 -Oregon Green and antibodies for macrophage markers including F4/80, @entity5 receptor ( @entity7 ), @entity6 , and @entity4 . Cells were then examined for expression of the above markers by flow cytometry. Furthermore, the ability of @entity3 conjugates to target the FR-expressing ATMs in @entity2 @entity1 was evaluated in vivo. RESULTS: A subset of the ATMs harvested from @entity2 @entity1 were found to express FR. Subpopulations of ATMs also simultaneously express both pro- and anti-inflammatory markers, and FR is expressed on both subsets. We then demonstrate that FR-expressing ATMs can be targeted with @entity3 -linked fluorescent dyes in vivo. CONCLUSIONS: FR are expressed on multiple subsets of ATMs and these subsets can be targeted with @entity3 -linked drugs, allowing for the possible development of FR-targeted therapies for @entity2 -related inflammatory diseases.

title: @entity3 receptor expression on XXXX and @entity0 adipose tissue macrophages.

answer: @entity1


abstract: OBJECTIVE AND DESIGN: Adipose tissue macrophages (ATMs) have been implicated in a number of @entity2 . Because the activated macrophages associated with many types of autoimmune and inflammatory diseases express a @entity3 receptor (FR) that can be exploited for FR-targeted drug delivery, we examined the visceral adipose tissue of @entity2 @entity1 and @entity0 to determine whether ATMs also express FR that are accessible by @entity3 conjugates. MATERIAL OR SUBJECTS: C57BL/6 or FATSO @entity1 fed on either a low- or high-fat diet were used in @entity1 studies. @entity0 adipose tissue were obtained from healthy volunteers during adipose reduction surgery. METHODS: Visceral adipose tissue was collected from both @entity2 @entity1 and @entity0 , collagenase digested, and stained with @entity3 -Oregon Green and antibodies for macrophage markers including F4/80, @entity5 receptor ( @entity7 ), @entity6 , and @entity4 . Cells were then examined for expression of the above markers by flow cytometry. Furthermore, the ability of @entity3 conjugates to target the FR-expressing ATMs in @entity2 @entity1 was evaluated in vivo. RESULTS: A subset of the ATMs harvested from @entity2 @entity1 were found to express FR. Subpopulations of ATMs also simultaneously express both pro- and anti-inflammatory markers, and FR is expressed on both subsets. We then demonstrate that FR-expressing ATMs can be targeted with @entity3 -linked fluorescent dyes in vivo. CONCLUSIONS: FR are expressed on multiple subsets of ATMs and these subsets can be targeted with @entity3 -linked drugs, allowing for the possible development of FR-targeted therapies for @entity2 -related inflammatory diseases.

title: @entity3 receptor expression on @entity1 and XXXX adipose tissue macrophages.

answer: @entity0


abstract: OBJECTIVES: @entity8 ( @entity8 ) is an early @entity3 characterized by the sudden onset of @entity2 in the parotid region at the first bite of each meal. The etiology is not certain, hence a standardized therapy does not exist. METHODS: A 50-year old @entity0 referred to us complaining of a swelling in the right parotid region. @entity4 ( @entity4 ) was diagnostic for pleomorphus @entity5 gland. A 50-year old @entity0 presented with a mass in the right side of the neck, @entity4 was diagnostic for parapharyngeal space @entity6 . The first @entity0 was submitted to total parotidectomy with @entity7 , the second to extracapsular dissection of the @entity1 . A week after surgery both @entity0 developed @entity8 . A qualitative/quantitative description of @entity2 was obtained by means of a self-coded questionnaire. The score ranges from 8 to 44, corresponding to the lowest and the highest discomfort possible, respectively. Acupuncture was used to treat these 2 @entity0 . The treatment protocol comprised 6 sessions, one per week, lasting 30 minutes each. RESULTS: Our questionnaire was administered before and after treatment and the score dropped from 33 to 25 in the female, from 30 to 15 in the male @entity0 . CONCLUSION: @entity8 is a complication of upper cervical surgery with a high morbidity rate. We describe the first two cases of @entity8 that were successfully treated with acupuncture in our ENT department. We believe that this procedure may represent a valid therapeutic alternative in the future.

title: Potential use of acupuncture in the treatment of first XXXX .

answer: @entity8


abstract: UNASSIGNED: Mitochondria produce @entity2 ( @entity2 ), critical for cellular metabolism. @entity2 declines with age, which is associated with @entity1 . Here, we measure retinal and brain @entity2 in normal C57BL/6 and complement factor H knockout @entity0 ( @entity6 (-/-)), which are proposed as a model of age-related @entity3 . We show a significant premature 30% decline in retinal @entity2 in @entity6 (-/-) @entity0 and a subsequent shift in expression of a @entity4 protein that is predominantly mitochondrial ( @entity5 ). Changes in @entity5 are associated with stress and neuroprotection. We find no differences in brain @entity2 between C57BL/6 and @entity6 (-/-) @entity0 . Near infrared (NIR) increases @entity2 and reduces @entity1 . @entity2 decline in @entity6 (-/-) @entity0 was corrected with NIR which also shifted @entity5 labeling patterns. @entity2 decline in @entity6 (-/-) @entity0 occurs before @entity1 becomes established and photoreceptor loss occurs and may relate to disease etiology. However, @entity2 levels were corrected with NIR. In summary, we provide evidence for a mitochondrial basis for this disease in @entity0 and correct this with simple light exposure known to improve mitochondrial function.

title: Mitochondrial decline precedes phenotype development in the complement factor XXXX model of retinal degeneration but can be corrected by near infrared light.

answer: @entity0


abstract: UNASSIGNED: Photooxidative damage and chronic innate immune activation have been implicated in @entity2 ( @entity2 ) dysfunction, a process that underlies blinding diseases such as @entity3 ( @entity3 ). To identify a potential molecular link between these mechanisms, we investigated whether @entity7 -mediated @entity6 activates the @entity5 inflammasome in @entity2 cells in vitro. We found that blue light irradiation (dominant wavelength 448  nm, irradiance 0.8  mW/cm(2), duration 6  h) of @entity7 -loaded primary @entity0 @entity2 cells and @entity0 cells induced photooxidative damage, lysosomal membrane permeabilization (79.5  % of cells vs. 3.8  % in nonirradiated controls), and cytosolic leakage of lysosomal enzymes. This resulted in activation of the inflammasome with activation of @entity9 and secretion of @entity4 (14.6 vs. 0.9  pg/ml in nonirradiated controls) and @entity8 (87.7 vs. 0.2  pg/ml in nonirradiated controls). Interleukin secretion was dependent on the activity of @entity5 , @entity9 , and lysosomal proteases @entity1 and L. These results demonstrate that accumulation of @entity7 -like material in vitro renders @entity2 cells susceptible to phototoxic destabilization of lysosomes, resulting in @entity5 inflammasome activation and secretion of inflammatory cytokines. This new mechanism of inflammasome activation links photooxidative damage and innate immune activation in @entity2 pathology and may provide novel targets for therapeutic intervention in @entity2 such as @entity3 . KEY MESSAGE:     Visible light irradiation of @entity7 -loaded @entity2 cells activates inflammasome.     Inflammasome activation results from lysosomal permeabilization and enzyme leakage.     Inflammasome activation induces secretion of inflammatory cytokines by @entity2 cells.     Photooxidative damage by visible light as new mechanism of inflammasome activation.     Novel link between hallmark pathogenetic features of @entity2 .

title: Light induces XXXX inflammasome activation in retinal pigment epithelial cells via @entity7 -mediated photooxidative damage.

answer: @entity5


abstract: UNASSIGNED: Photooxidative damage and chronic innate immune activation have been implicated in @entity2 ( @entity2 ) dysfunction, a process that underlies blinding diseases such as @entity3 ( @entity3 ). To identify a potential molecular link between these mechanisms, we investigated whether @entity7 -mediated @entity6 activates the @entity5 inflammasome in @entity2 cells in vitro. We found that blue light irradiation (dominant wavelength 448  nm, irradiance 0.8  mW/cm(2), duration 6  h) of @entity7 -loaded primary @entity0 @entity2 cells and @entity0 cells induced photooxidative damage, lysosomal membrane permeabilization (79.5  % of cells vs. 3.8  % in nonirradiated controls), and cytosolic leakage of lysosomal enzymes. This resulted in activation of the inflammasome with activation of @entity9 and secretion of @entity4 (14.6 vs. 0.9  pg/ml in nonirradiated controls) and @entity8 (87.7 vs. 0.2  pg/ml in nonirradiated controls). Interleukin secretion was dependent on the activity of @entity5 , @entity9 , and lysosomal proteases @entity1 and L. These results demonstrate that accumulation of @entity7 -like material in vitro renders @entity2 cells susceptible to phototoxic destabilization of lysosomes, resulting in @entity5 inflammasome activation and secretion of inflammatory cytokines. This new mechanism of inflammasome activation links photooxidative damage and innate immune activation in @entity2 pathology and may provide novel targets for therapeutic intervention in @entity2 such as @entity3 . KEY MESSAGE:     Visible light irradiation of @entity7 -loaded @entity2 cells activates inflammasome.     Inflammasome activation results from lysosomal permeabilization and enzyme leakage.     Inflammasome activation induces secretion of inflammatory cytokines by @entity2 cells.     Photooxidative damage by visible light as new mechanism of inflammasome activation.     Novel link between hallmark pathogenetic features of @entity2 .

title: Light induces @entity5 inflammasome activation in retinal pigment epithelial cells via XXXX -mediated photooxidative damage.

answer: @entity7


abstract: BACKGROUND: This paper demonstrates the mechanism of a multidimensional computerized adaptive test (CAT) to measure @entity2 in @entity0 with @entity1 ( @entity1 ). A CAT can be used to precisely measure @entity0 -reported outcomes at an individual level as items are consequentially selected based on the @entity0 's previous answers. The item bank of the CAT Fatigue @entity1 has been developed from the @entity0 ' perspective and consists of 196 items pertaining to three @entity2 dimensions: severity, impact and variability of @entity2 . METHODS: The CAT Fatigue @entity1 was completed by fifteen @entity0 . To test the CAT's working mechanism, we applied the flowchart-check-method. The adaptive item selection procedure for each @entity0 was checked by the researchers. The estimated @entity2 levels and the measurement precision per dimension were illustrated with the selected items, answers and flowcharts. RESULTS: The CAT Fatigue @entity1 selected all items in a logical sequence and those items were selected which provided the most information about the @entity0 's individual @entity2 . Flowcharts further illustrated that the CAT reached a satisfactory measurement precision, with less than 20 items, on the dimensions severity and impact and to somewhat lesser extent also for the dimension variability. @entity0 ' @entity2 scores varied across the three dimensions; sometimes severity scored highest, other times impact or variability. The CAT's ability to display different @entity2 experiences can improve communication in daily clinical practice, guide interventions, and facilitate research into possible predictors of @entity2 . CONCLUSIONS: The results indicate that the CAT Fatigue @entity1 measures precise and comprehensive. Once it is examined in more detail in a consecutive, elaborate validation study, the CAT will be available for implementation in daily clinical practice and for research purposes.

title: Working mechanism of a multidimensional computerized adaptive test for XXXX in @entity1 .

answer: @entity2


abstract: BACKGROUND: This paper demonstrates the mechanism of a multidimensional computerized adaptive test (CAT) to measure @entity2 in @entity0 with @entity1 ( @entity1 ). A CAT can be used to precisely measure @entity0 -reported outcomes at an individual level as items are consequentially selected based on the @entity0 's previous answers. The item bank of the CAT Fatigue @entity1 has been developed from the @entity0 ' perspective and consists of 196 items pertaining to three @entity2 dimensions: severity, impact and variability of @entity2 . METHODS: The CAT Fatigue @entity1 was completed by fifteen @entity0 . To test the CAT's working mechanism, we applied the flowchart-check-method. The adaptive item selection procedure for each @entity0 was checked by the researchers. The estimated @entity2 levels and the measurement precision per dimension were illustrated with the selected items, answers and flowcharts. RESULTS: The CAT Fatigue @entity1 selected all items in a logical sequence and those items were selected which provided the most information about the @entity0 's individual @entity2 . Flowcharts further illustrated that the CAT reached a satisfactory measurement precision, with less than 20 items, on the dimensions severity and impact and to somewhat lesser extent also for the dimension variability. @entity0 ' @entity2 scores varied across the three dimensions; sometimes severity scored highest, other times impact or variability. The CAT's ability to display different @entity2 experiences can improve communication in daily clinical practice, guide interventions, and facilitate research into possible predictors of @entity2 . CONCLUSIONS: The results indicate that the CAT Fatigue @entity1 measures precise and comprehensive. Once it is examined in more detail in a consecutive, elaborate validation study, the CAT will be available for implementation in daily clinical practice and for research purposes.

title: Working mechanism of a multidimensional computerized adaptive test for @entity2 in XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate ranibizumab 0.5 mg using bimonthly monitoring and individualized re-treatment after monthly follow-up for 6 months in @entity0 with @entity1 due to @entity2 ( @entity2 ). DESIGN: A phase IIIb, 18-month, prospective, open-label, multicenter, single-arm study in the United Kingdom. @entity0 : @entity0 (N  = 109) with @entity1 due to @entity2 . METHODS: @entity0 received 3 initial monthly ranibizumab 0.5 mg injections (day 0 to month 2), followed by individualized best-corrected visual acuity (BCVA) and optical coherence tomography-guided re-treatment with monthly (months 3-5) and subsequent bimonthly follow-up (months 6-18). Laser was allowed after month  6. MAIN OUTCOME MEASURES: Mean change in BCVA from baseline to month 12 (primary end point), mean change in BCVA and central retinal thickness (CRT) from baseline to month 18, gain of >= 10 and >= 15 letters, treatment exposure, and incidence of adverse events over 18 months. RESULTS: Of 109 @entity0 , 100 (91.7%) and 99 (90.8%) completed the 12 and 18 months of the study, respectively. The mean age was 63.7 years, the mean duration of @entity2 was 40 months, and 77.1% of the @entity0 had received prior laser treatment (study eye). At baseline, mean BCVA was 62.9 letters, 20% of @entity0 had a baseline BCVA of >73 letters, and mean baseline CRT was 418.1  m, with 32% of @entity0 having a baseline CRT <300  m. The mean change in BCVA from baseline to month 6 was  +6.6 letters (95% confidence interval [CI], 4.9-8.3), and after institution of bimonthly treatment the mean change in BCVA at month 12 was  +4.8 letters (95% CI, 2.9-6.7; P < 0.001) and  +6.5 letters (95% CI, 4.2-8.8) at month 18. The proportion of @entity0 gaining >= 10 and >= 15 letters was 24.8% and 13.8% at month 12 and 34.9% and 19.3% at month 18, respectively. @entity0 received a mean of 6.8 and 8.5 injections over 12 and 18 months, respectively. No new ocular or nonocular safety findings were observed during the study. CONCLUSIONS: The BCVA gain achieved in the initial 6-month treatment period was maintained with an additional 12 months of bimonthly ranibizumab PRN treatment.

title: Ranibizumab 0.5 mg for XXXX with Bimonthly Monitoring after a Phase of Initial Treatment: 18-Month, Multicenter, Phase IIIB RELIGHT Study.

answer: @entity2


abstract: BACKGROUND: Isolated dissecting @entity6 (PICA) are rare lesions, which carry high risk of rebleeding and mortality. However, the existing literature concerning predictors of outcome after endovascular treatment is limited and controversial. Our present study retrospectively reviewed and analyzed the clinical outcome of endovascular treatment-ruptured PICA-dissecting @entity3 and explored the predictors of outcome. METHODS: We retrospectively reviewed 17 consecutive @entity0 with ruptured PICA dissecting @entity3 that underwent endovascular treatment from January 2003 to January 2014. Nine @entity0 underwent selective coiling, whereas 7 @entity0 underwent parent @entity2 and 1 @entity0 underwent stent-assisted coiling. Follow-up outcomes were evaluated using the modified Rankin Scale. The clinical outcomes of @entity0 were categorized as favorable (modified Rankin Scale [mRS] score 0-1) or unfavorable (mRS score 2-6). RESULTS: Favorable outcomes (mRS score 0-1) were obtained in 13 of 17 @entity0 . Post-treatment recurrence occurred in 1 @entity0 with selective coiling in the 15-month follow-up, and the @entity0 received stent-assisted coiling. The only @entity0 with stent-assisted coiling developed PICA occlusion during follow-up. @entity3 located in distal segment usually presented with @entity4 (P  =  .015). @entity1 , coexisting @entity5 , and time to operation (latter than 2  weeks) were associated with unfavorable outcome. CONCLUSIONS: Endovascular treatment of isolated dissecting @entity3 of PICA had excellent clinical outcomes, @entity1 , coexisting @entity5 , and time to operation (latter than 2  weeks), which were associated with unfavorable outcome. Long-term follow-ups are necessary to provide stronger conclusions.

title: Endovascular Treatment of Dissecting XXXX and Predictors of Outcome.

answer: @entity6


abstract: OBJECTIVE: To establish a novel method to determine specific type of @entity6 through laser microdissection and mass spectrometry ( @entity9 / @entity1 ) based proteomic analysis. METHODS: There were 138 @entity2 -fixed and @entity4 -embedded (FFPE) biopsy samples of @entity0 who were diagnosed as @entity5 used in this study. For each case, a 10  m section stained with congo-red and positive @entity3 were identified under fluorescent light, followed by micro-dissection and mass spectrometry analysis. The @entity6 subtype was confirmed based on the most abundant amyloid protein. RESULTS: The tissue types of 138 specimens were as following: subcutaneous abdominal fat accounted for 26%, tongue for 19%, gingiva for 11%, kidney for 9%, intestine for 9%, heart for 6% and others for 20%. Specific types of amyloid were accurately detected in 121 cases, including 106 (87.6%) @entity7 ( @entity7 ) type, 7 (5.8%) amyloid trans-thy-retin (ATTR), 2 (1.7%) amyloidogenic protein A (AA), 2 (1.7%) @entity8 ( @entity8 )/ @entity7 + @entity8 , 2 (1.7%) fibrinogen alpha chain (AFib), 1(0.8%) amyloid apolipoprotein A-type II (AApoA-II) and one (0.8%) amyloid lysozyme (ALys). Diagnosis of @entity6 was excluded in 5 cases. The types of twelve cases were indeterminate by @entity9 / @entity1 . On the whole, @entity9 / @entity1 reached 91.3% accuracy rate in amyloid typing. Commonly involved organs (for example, heart, kidney and liver) turned out to be suitable sources of FFPE samples with typing success rate of almost 100%. In contrast, @entity1 analysis was successful in only 83.3% of subcutaneous abdominal fat samples. CONCLUSION: @entity9 / @entity1 method provided a more direct technique for accurate typing of @entity6 in a single procedure.

title: [Classification of XXXX by laser micro-dissection and mass spectrometry based proteomic analysis].

answer: @entity6


abstract: BACKGROUND: @entity2 is a global public health problem caused by the spirochaete @entity1 . Our previous studies found differences in disease severity between @entity4 - and @entity3 SZ-infected @entity0 . We hypothesized that genes that are differentially expressed between Borrelia isolates encode bacterial factors that contribute to disease diversity. METHODS: The present study used high-throughput sequencing technology to characterize and compare the transcriptional profiles of @entity4 and @entity3 SZ cultured in vitro. Real-time quantitative RT-PCR was used to validate selected data from RNA-seq experiments. RESULTS: A total of 731 genes were differentially expressed between @entity4 and @entity3 SZ isolates, including those encoding lipoproteins and purine transport proteins. The fold difference in expression for @entity3 SZ versus @entity4 ranged from 22.07 to 1.01. Expression of the OspA, OspB and DbpB genes were significantly lower in @entity3 SZ compared to @entity4 . CONCLUSIONS: The results support the hypothesis that global changes in gene expression underlie differences in Borrelia pathogenicity. The findings also provide an empirical basis for studying the mechanism of action of specific genes as well as their potential usefulness for the diagnosis and management of @entity2 .

title: RNA-Seq-based analysis of changes in XXXX gene expression linked to pathogenicity.

answer: @entity1


abstract: BACKGROUND: Red foxes ( @entity5 ) have recently been recognized as potential reservoirs of several vector-borne pathogens and a source of infection for domestic @entity1 and @entity0 , mostly due to their close vicinity to urban areas and frequent exposure to different arthropod vectors. The aim of this study was to investigate the presence and distribution of @entity2 spp., Hepatozoon canis, Anaplasma spp., Bartonella spp., 'Candidatus Neoehrlichia mikurensis', @entity4 , Rickettsia spp. and blood filaroid @entity3 in free-ranging red foxes from Bosnia and Herzegovina. METHODS: Spleen samples from a total of 119 red foxes, shot during the hunting season between October 2013 and April 2014 throughout Bosnia and Herzegovina, were examined for the presence of blood vector-borne pathogens by conventional PCRs and sequencing. RESULTS: In the present study, three species of apicomplexan parasites were molecularly identified in 73 red foxes from the entire sample area, with an overall prevalence of 60.8%. The DNA of @entity6 , B. cf. microti and @entity6 was found in 1 (0.8%), 38 (31.9%) and 46 (38.6%) spleen samples, respectively. In 11 samples (9.2%) co-infections with B. cf. microti and @entity6 were detected and one fox harboured all three parasites (0.8%). There were no statistically significant differences between geographical region, sex or age of the host in the infection prevalence of B. cf. microti, although females (52.9%; 18/34) were significantly more infected with @entity6 than males (32.9%; 28/85). The presence of vector-borne bacteria and filaroid @entity3 was not detected in our study. CONCLUSION: This is the first report of @entity6 , B. cf. microti and @entity6 parasites in foxes from Bosnia and Herzegovina and the data presented here provide a first insight into the distribution of these pathogens among the red fox population. Moreover, the relatively high prevalence of B. cf. microti and @entity6 reinforces the assumption that this wild canid species might be a possible reservoir and source of infection for domestic @entity1 .

title: A molecular survey of vector-borne pathogens in red foxes ( XXXX ) from Bosnia and Herzegovina.

answer: @entity5


abstract: Purpose: The purpose of this study is to compare the treatment outcomes for locally advanced resectable @entity1 between organ-preserving chemoradiotherapy (CRT) and surgery followed by radiotherapy (SRT). Materials and Methods: We reviewed 91 @entity0 with stage III/IV @entity3 treated with radiotherapy. In the CRT group (n=34), 18 @entity0 were treated with concurrent CRT and 16 @entity0 with induction chemotherapy plus concurrent CRT. In the SRT group (n=57), 6 patents were treated with total laryngopharyngectomy (TLP), 34 @entity0 with total laryngectomy and partial pharyngectomy ( @entity4 /PP), and 17 @entity0 with partial pharyngectomy (PP), which were followed by adjuvant RT (n=41) or CRT (n=16). The median RT dose was 70 Gy for CRT and 59.4 Gy for SRT. Results: Five-year local control (84.1% vs. 90.9%), and disease-free (DFS: 51.0% vs. 52.7%) and overall survival (OS: 58.6% vs. 56.6%) showed no significant difference between the CRT and SRT groups. The functional larynx-preservation rate was higher in the CRT group (88.2% vs. 29.8%). Treatment-related @entity2 , requiring surgical intervention, occurred more frequently in the SRT group (37% vs. 12%). In the SRT group, @entity4 resulted in a significantly higher DFS than larynx-sparing surgery (63.9% vs. 26.5%, p = 0.027). Treatment outcome of the SRT group improved when only @entity0 with @entity4 were considered (n = 40); however, 5-year OS (67.1% vs. 58.6%, p = 0.830) and DFS (63.9% vs. 51.0%, p = 0.490) did not improve significantly when compared to the CRT group. Conclusion: Organ preserving CRT provided a treatment outcome that is comparable to SRT for locally advanced @entity1 , while offering an opportunity for functional larynx-preservation and reduced treatment-related @entity2 .

title: Definitive Chemoradiotherapy versus Surgery Followed by Adjuvant Radiotherapy in Resectable Stage III/IV XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity10 is a rare @entity8 whose hallmark is atypical @entity11 . Symptoms can include @entity2 , @entity5 , and abnormal blood cell counts. High levels of @entity6 ( @entity6 ) are observed frequently in this disorder and are believed to drive the disease. Recently, therapies that target @entity6 or its receptor have been shown to be effective in @entity11 . CASE PRESENTATION: We report the case of a 76-year-old Caucasian @entity0 with aggressive biopsy-proven @entity11 who experienced pulmonary and lymph node involvement, as well as @entity2 and @entity3 . He was treated with siltuximab, a chimeric anti- @entity6 antibody. After 5 months, fluorodeoxyglucose positron emission tomography computed tomography scans showed marked improvement in his lungs, but worsening mediastinal disease, consistent with a mixed response. Biopsy of the mediastinal disease revealed lymphoplasmacytic infiltrate with non-caseating, ill-defined @entity7 and @entity9 consistent with @entity4 . Prednisone 50mg by mouth daily was started, which was tapered to 2.0-5.0mg daily. Siltuximab was continued. A subsequent fluorodeoxyglucose positron emission tomography computed tomography scan showed near-complete resolution of lung and mediastinal disease, now ongoing for 3.5+ years without serious adverse events. CONCLUSIONS: Lymphomas have previously been reported to coexist with @entity4 , albeit rarely, but there has been only a single previous case of this type with @entity11 . Of importance, early recognition of the presence of @entity4 in our @entity0 prevented discontinuation of siltuximab therapy due to "progression." Our experience may also have broader implications in that it suggests that etiology of "mixed responses" should be confirmed by performing biopsies on the progressive @entity1 .

title: @entity11 and XXXX , a rare association resulting in a "mixed" response: a case report.

answer: @entity4


abstract: INTRODUCTION: @entity10 is a rare @entity8 whose hallmark is atypical @entity11 . Symptoms can include @entity2 , @entity5 , and abnormal blood cell counts. High levels of @entity6 ( @entity6 ) are observed frequently in this disorder and are believed to drive the disease. Recently, therapies that target @entity6 or its receptor have been shown to be effective in @entity11 . CASE PRESENTATION: We report the case of a 76-year-old Caucasian @entity0 with aggressive biopsy-proven @entity11 who experienced pulmonary and lymph node involvement, as well as @entity2 and @entity3 . He was treated with siltuximab, a chimeric anti- @entity6 antibody. After 5 months, fluorodeoxyglucose positron emission tomography computed tomography scans showed marked improvement in his lungs, but worsening mediastinal disease, consistent with a mixed response. Biopsy of the mediastinal disease revealed lymphoplasmacytic infiltrate with non-caseating, ill-defined @entity7 and @entity9 consistent with @entity4 . Prednisone 50mg by mouth daily was started, which was tapered to 2.0-5.0mg daily. Siltuximab was continued. A subsequent fluorodeoxyglucose positron emission tomography computed tomography scan showed near-complete resolution of lung and mediastinal disease, now ongoing for 3.5+ years without serious adverse events. CONCLUSIONS: Lymphomas have previously been reported to coexist with @entity4 , albeit rarely, but there has been only a single previous case of this type with @entity11 . Of importance, early recognition of the presence of @entity4 in our @entity0 prevented discontinuation of siltuximab therapy due to "progression." Our experience may also have broader implications in that it suggests that etiology of "mixed responses" should be confirmed by performing biopsies on the progressive @entity1 .

title: XXXX and @entity4 , a rare association resulting in a "mixed" response: a case report.

answer: @entity11


abstract: Twenty-four @entity0 were refueling a missile when a large spill of oxidizer occurred. Three crewmen were exposed to very high concentrations of the @entity8 of @entity6 . One died within minutes. Severe @entity4 developed in the other two, one of whom survived. Twenty-one other workers were exposed to minimal to moderate concentrations of the gas. Most remained asymptomatic while six had @entity5 of breath, cough, or hemoptysis. The three with persistent symptoms received corticosteroid therapy; the complaints resolved in two. Corticosteroid therapy for four asymptomatic @entity0 who had moderate @entity3 two weeks after the accident may have aborted the second stage of @entity7 injury. Six @entity0 with minimal exposure had persisting @entity1 , @entity2 , and emotional difficulties. These latter findings may represent an unusual complication of exposure to these gases.

title: The McConnell missile accident. Clinical spectrum of XXXX exposure.

answer: @entity7


abstract: BACKGROUND: A new technique of @entity0 ( @entity0 ) using laparoscopically harvested pedicled omental flap has been developed in the past 10  years. This study aimed to evaluate the feasibility of this technique. METHODS: Twenty-five @entity1 underwent @entity0 using laparoscopically harvested omental flap. Operative time, @entity3 , complications, recurrence, and cosmetic outcomes were prospectively analyzed. RESULTS: Between June 2010 and March 2014, 25 @entity1 were recruited in our study. The surgery was performed successfully in 24 @entity1 . All these @entity1 recovered uneventfully after the surgery. Mean operative time was 310  min, ranging from 205 to 410  min. Mean @entity3 was 70  ml, ranging from 20 to 150  ml. @entity1 were followed up for 32  months on average, ranging from 6 to 51  months. Four @entity1 complained of mild epigastric discomfort. One @entity1 had local recurrence and distant bone and liver @entity2 and died 11  months after the surgery. One @entity1 was diagnosed with @entity2 in the lung, bone, and liver without local recurrence 2  years after surgery. The cosmetic satisfaction rate was 91.7% and 95.8% by surgeon and @entity1 , respectively. CONCLUSION: @entity0 with laparoscopically harvested omental flap might be a feasible technique with a good cosmetic outcome.

title: The XXXX with pedicled omental flap harvested by laparoscopy: initial experiences from China.

answer: @entity0


abstract: BACKGROUND: the @entity2 ( @entity2 ) was validated as a predictor of adverse outcomes in community-dwelling older @entity0 . In our hospital, the use of the @entity2 in emergency admissions of @entity0 aged >=  75 years was introduced under the Commissioning for Quality and Innovation payment framework. AIM: we retrospectively studied the association of the @entity2 with @entity0 characteristics and outcomes. DESIGN: retrospective observational study in a large tertiary university National Health Service hospital in UK. METHODS: the @entity2 was correlated with transfer to specialist Geriatric ward, length of stay (LOS), in- @entity0 mortality and 30-day readmission rate. RESULTS: between 1st August 2013 and 31st July 2014, there were 11 271 emergency admission episodes of @entity0 aged >=  75 years (all specialties), corresponding to 7532 unique @entity0 (first admissions); of those, 5764 had the @entity2 measured by the admitting team (81% of them within 72   hr of admission). After adjustment for age, gender, Charlson comorbidity index and history of @entity1 and/or current cognitive concern, the @entity2 was an independent predictor of in- @entity0 mortality [odds ratio (OR)   =   1.60, 95% confidence interval (CI): 1.48 to 1.74, P   <   0.001], transfer to Geriatric ward (OR   =   1.33, 95% CI: 1.24 to 1.42, P   <   0.001) and LOS >=  10 days (OR   =   1.19, 95% CI: 1.14 to 1.23, P   <   0.001). The @entity2 was not a multivariate predictor of 30-day readmission. CONCLUSIONS: the @entity2 may help predict in- @entity0 mortality and target specialist geriatric resources within the hospital. Usual hospital metrics such as mortality and LOS should take into account measurable @entity0 complexity.

title: Association of the XXXX with hospital outcomes.

answer: @entity2


abstract: BACKGROUND: Asthma is the most common chronic condition of childhood and disproportionately affects inner-city minority @entity0 . Low rates of @entity2 preventer medication adherence is a major contributor to poor @entity2 control in these @entity0 . Web-based methods have potential to improve @entity0 knowledge and medication adherence by providing interactive @entity0 education, monitoring of symptoms and medication use, and by facilitation of communication and teamwork among @entity0 and health care providers. Few studies have evaluated web-based @entity2 support environments using all of these potentially beneficial interventions. The multidimensional website created for this study, BostonBreathes, was designed to intervene on multiple levels, and was evaluated in a pilot trial. METHODS: An interactive, engaging website for @entity0 with @entity2 was developed to promote adherence to @entity2 medications, provide a platform for teamwork between caregivers and @entity0 , and to provide primary care providers with up-to-date symptom information and data on medication use. Fifty-eight (58) @entity0 primarily from inner city Boston with persistent-level @entity2 were randomised to either usual care or use of BostonBreathes. Subjects completed @entity2 education activities, and reported their symptoms and medication use. Primary care providers used a separate interface to monitor their @entity0 ' website use, their reported symptoms and medication use, and were able to communicate online via a discussion board with their @entity0 and with an @entity2 specialist. RESULTS: After 6-months, reported wheezing improved significantly in both intervention and control groups, and there were significant improvements in the intervention group only in night-time awakening and @entity1 , but there were no significant differences between intervention and control groups in these measures. Emergency room or acute visits to a physician for @entity2 did not significantly change in either group. Among the subgroup of subjects with low controller medication adherence at baseline, adherence improved significantly only in the intervention group. Knowledge of the purpose of controller medicine increased significantly in the intervention group, a statistically significant improvement over the control group. CONCLUSIONS: This pilot study suggests that a multidimensional web-based educational, monitoring, and communication platform may have positive influences on pediatric @entity0 ' @entity2 -related knowledge and use of @entity2 preventer medications.

title: Evaluation of a web-based XXXX self-management system: a randomised controlled pilot trial.

answer: @entity2


abstract: BACKGROUND: @entity8 ( @entity8 ) is a rare disease, currently considered a benign @entity2 of unknown etiology, and whose treatment is still unclear and challenging. @entity0 AND METHODS: Two @entity0 in their thirties consulted for itchy lesions of the right ear. Both presented with a @entity4 papulonodular infiltration of the auricle, with a nodule at the entrance to the external auditory canal in the first @entity0 . Laboratory tests showed no abnormalities and in particular no @entity7 or elevated serum immunoglobulin E. In both cases, histology of lesional skin showed @entity2 with thick-walled vessels lined by plump endothelial cells, protruding into the lumen, together with a mixed dermal inflammatory infiltrate consisting primarily of eosinophils and lymphocytes. A diagnosis of @entity8 was made in both @entity0 based on clinical and histological features. MRA revealed no underlying @entity6 in both cases. @entity0 started treatment with 0.1% @entity5 ointment twice daily. The @entity9 sensation and bleeding had completely subsided within two weeks and the reddish infiltration and nodules had practically disappeared after two months of topical @entity5 . Continuous application resulted in no recurrence at 6 months of follow-up. DISCUSSION: Treatment of @entity8 is still poorly standardized due to doubts concerning the pathophysiology of this rare condition and the small number of available studies. Topical @entity5 was originally developed for the treatment of moderate to severe @entity3 because of its anti-inflammatory and immunomodulatory properties. Recent studies suggest that this drug may be effective in treating other forms of inflammatory @entity1 . Our two observations suggest that @entity5 ointment also represents potentially valuable treatment in AHLE.

title: [Treatment of @entity8 with @entity7 ( XXXX ) using topical @entity5 : Two cases].

answer: @entity8


abstract: BACKGROUND: @entity8 ( @entity8 ) is a rare disease, currently considered a benign @entity2 of unknown etiology, and whose treatment is still unclear and challenging. @entity0 AND METHODS: Two @entity0 in their thirties consulted for itchy lesions of the right ear. Both presented with a @entity4 papulonodular infiltration of the auricle, with a nodule at the entrance to the external auditory canal in the first @entity0 . Laboratory tests showed no abnormalities and in particular no @entity7 or elevated serum immunoglobulin E. In both cases, histology of lesional skin showed @entity2 with thick-walled vessels lined by plump endothelial cells, protruding into the lumen, together with a mixed dermal inflammatory infiltrate consisting primarily of eosinophils and lymphocytes. A diagnosis of @entity8 was made in both @entity0 based on clinical and histological features. MRA revealed no underlying @entity6 in both cases. @entity0 started treatment with 0.1% @entity5 ointment twice daily. The @entity9 sensation and bleeding had completely subsided within two weeks and the reddish infiltration and nodules had practically disappeared after two months of topical @entity5 . Continuous application resulted in no recurrence at 6 months of follow-up. DISCUSSION: Treatment of @entity8 is still poorly standardized due to doubts concerning the pathophysiology of this rare condition and the small number of available studies. Topical @entity5 was originally developed for the treatment of moderate to severe @entity3 because of its anti-inflammatory and immunomodulatory properties. Recent studies suggest that this drug may be effective in treating other forms of inflammatory @entity1 . Our two observations suggest that @entity5 ointment also represents potentially valuable treatment in AHLE.

title: [Treatment of XXXX with @entity7 ( @entity8 ) using topical @entity5 : Two cases].

answer: @entity8


abstract: BACKGROUND: @entity8 ( @entity8 ) is a rare disease, currently considered a benign @entity2 of unknown etiology, and whose treatment is still unclear and challenging. @entity0 AND METHODS: Two @entity0 in their thirties consulted for itchy lesions of the right ear. Both presented with a @entity4 papulonodular infiltration of the auricle, with a nodule at the entrance to the external auditory canal in the first @entity0 . Laboratory tests showed no abnormalities and in particular no @entity7 or elevated serum immunoglobulin E. In both cases, histology of lesional skin showed @entity2 with thick-walled vessels lined by plump endothelial cells, protruding into the lumen, together with a mixed dermal inflammatory infiltrate consisting primarily of eosinophils and lymphocytes. A diagnosis of @entity8 was made in both @entity0 based on clinical and histological features. MRA revealed no underlying @entity6 in both cases. @entity0 started treatment with 0.1% @entity5 ointment twice daily. The @entity9 sensation and bleeding had completely subsided within two weeks and the reddish infiltration and nodules had practically disappeared after two months of topical @entity5 . Continuous application resulted in no recurrence at 6 months of follow-up. DISCUSSION: Treatment of @entity8 is still poorly standardized due to doubts concerning the pathophysiology of this rare condition and the small number of available studies. Topical @entity5 was originally developed for the treatment of moderate to severe @entity3 because of its anti-inflammatory and immunomodulatory properties. Recent studies suggest that this drug may be effective in treating other forms of inflammatory @entity1 . Our two observations suggest that @entity5 ointment also represents potentially valuable treatment in AHLE.

title: [Treatment of @entity8 with @entity7 ( @entity8 ) using topical XXXX : Two cases].

answer: @entity5


abstract: BACKGROUND: @entity8 ( @entity8 ) is a rare disease, currently considered a benign @entity2 of unknown etiology, and whose treatment is still unclear and challenging. @entity0 AND METHODS: Two @entity0 in their thirties consulted for itchy lesions of the right ear. Both presented with a @entity4 papulonodular infiltration of the auricle, with a nodule at the entrance to the external auditory canal in the first @entity0 . Laboratory tests showed no abnormalities and in particular no @entity7 or elevated serum immunoglobulin E. In both cases, histology of lesional skin showed @entity2 with thick-walled vessels lined by plump endothelial cells, protruding into the lumen, together with a mixed dermal inflammatory infiltrate consisting primarily of eosinophils and lymphocytes. A diagnosis of @entity8 was made in both @entity0 based on clinical and histological features. MRA revealed no underlying @entity6 in both cases. @entity0 started treatment with 0.1% @entity5 ointment twice daily. The @entity9 sensation and bleeding had completely subsided within two weeks and the reddish infiltration and nodules had practically disappeared after two months of topical @entity5 . Continuous application resulted in no recurrence at 6 months of follow-up. DISCUSSION: Treatment of @entity8 is still poorly standardized due to doubts concerning the pathophysiology of this rare condition and the small number of available studies. Topical @entity5 was originally developed for the treatment of moderate to severe @entity3 because of its anti-inflammatory and immunomodulatory properties. Recent studies suggest that this drug may be effective in treating other forms of inflammatory @entity1 . Our two observations suggest that @entity5 ointment also represents potentially valuable treatment in AHLE.

title: [Treatment of @entity8 with XXXX ( @entity8 ) using topical @entity5 : Two cases].

answer: @entity7


abstract: INTRODUCTION: Linear growth rate (LGR) is the most commonly employed trigger for definitive intervention in @entity0 with renal masses managed with an initial period of @entity3 ( @entity3 ). Using our institutional cohort, we explored the association between @entity2 anatomic complexity at presentation and LGR in @entity0 managed with @entity3 . METHODS AND MATERIALS: Enhancing renal masses managed expectantly for at least 6 months were included for analysis. The association between Nephrometry Score and LGR was assessed using generalized estimating equations, adjusting for the age, Charlson score, race, sex, and initial @entity2 size. RESULTS: Overall, 346 @entity0 (401 masses) met the inclusion criteria (18% >=  cT1b), with a median follow-up of 37 months (range: 6-169). Of these, 44% @entity0 showed progression to definitive intervention with a median duration of 27 months (range: 6-130). On comparing @entity0 managed expectantly to those requiring intervention, no difference was seen in median @entity2 size at presentation (2.2 vs. 2.2 cm), whereas significant differences in median age (74 vs. 65 y, P < 0.001), Charlson comorbidity score (3 vs. 2, P<0.001), and average LGR (0.23 vs. 0.49 cm/y, P < 0.001) were observed between groups. Following adjustment, for each 1-point increase in Nephrometry Score sum, the average @entity2 LGR increased by 0.037 cm/y (P = 0.002). Of the entire cohort, 6 @entity0 (1.7%) showed progression to @entity1 . CONCLUSIONS: The demonstrated association between anatomic @entity2 complexity at presentation and renal masses of LGR of clinical stage 1 under @entity3 may afford a clinically useful cue to tailor individual @entity0 radiographic surveillance schedules and warrants further evaluation.

title: Is anatomic complexity associated with renal tumor growth kinetics under XXXX ?

answer: @entity3


abstract: PURPOSE: Survivorship care plans (SCPs) have been suggested to reduce fragmentation of care experienced by @entity2 survivors. Acceptance of SCPs is high, but trials in the United States are few. This pilot study used a quasiexperimental design to examine the outcomes achieved by @entity0 survivors receiving a standardized @entity3 visit at one of seven comprehensive @entity2 centers. MATERIALS AND METHODS: Outcomes were assessed before and again 3 months after delivery of an @entity3 and included survivors' use of and satisfaction with SCPs, perceived knowledge about survivorship, and assessment of the quality and coordination of survivorship care. RESULTS: One hundred thirty-nine survivors of @entity0 completed baseline and follow-up measures and received a standardized @entity3 visit. @entity1 most commonly used @entity3 materials to make decisions about exercise (64%), which tests to receive and when (62%), and dietary changes (62%). Only 21% shared the @entity3 with their primary care provider during that time. Satisfaction with the @entity3 was high, with 90% of @entity1 reporting being at least satisfied with the @entity3 . Perceived knowledge about survivorship improved after @entity3 delivery, as did perceived care coordination and the provider's knowledge of the effects of @entity2 on survivors (all P < .001). Individuals closer to the time of diagnosis reported greater satisfaction with and use of SCPs. CONCLUSION: This study demonstrates improvements in perceived knowledge and quality of survivorship care after receipt of a comprehensive @entity3 . Survivors were satisfied with their @entity3 , and those closer to diagnosis reported greater satisfaction with and use of the materials.

title: Outcomes and satisfaction after delivery of a XXXX survivorship care plan: results of a multicenter trial.

answer: @entity0


abstract: UNASSIGNED: @entity1 is the most common complaint among @entity0 with @entity1 . Conventional treatment does not always relieve @entity1 satisfactorily. Therefore, many @entity0 with @entity1 have turned to complementary therapies to help them with their physical, emotional, and spiritual well-being. Massage therapy is increasingly used for symptom relief in @entity0 with @entity1 . The current study aimed to investigate by meta-analysis the effects of massage therapy for @entity1 @entity0 experiencing @entity2 . Nine electronic databases were systematically searched for studies published through August 2013 in English, Chinese, and Korean. Methodological quality was assessed using the Physiotherapy Evidence Database (PEDro) and Cochrane risk-of-bias scales. Twelve studies, including 559 @entity0 , were used in the meta-analysis. In 9 high-quality studies based on the PEDro scale (standardized mean difference, -1.24; 95% confidence interval, -1.72 to -0.75), we observed reduction in @entity1 after massage. Massage therapy significantly reduced @entity1 compared with no massage treatment or conventional care (standardized mean difference, -1.25; 95% confidence interval, -1.63 to -0.87). Our results indicate that massage is effective for the relief of @entity1 , especially for surgery-related @entity2 . Among the various types of massage, foot reflexology appeared to be more effective than body or aroma massage. Our meta-analysis indicated a beneficial effect of massage for relief of @entity1 . Further well-designed, large studies with longer follow-up periods are needed to be able to draw firmer conclusions regarding the effectiveness.

title: Meta-Analysis of Massage Therapy on Cancer XXXX .

answer: @entity2


abstract: @entity1 are cultivated in southwest Greenland without the use of pesticides and with limited crop rotation. Despite the fact that plant-pathogenic fungi are present, no severe-disease outbreaks have yet been observed. In this report, we document that a @entity1 soil at Inneruulalik in southern Greenland is suppressive against Rhizoctonia solani Ag3 and uncover the suppressive antifungal mechanism of a highly potent biocontrol bacterium, @entity2 In5, isolated from the suppressive @entity1 soil. A combination of molecular genetics, genomics, and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) imaging mass spectrometry (IMS) revealed an antifungal genomic island in @entity2 In5 encoding two nonribosomal peptides, nunamycin and nunapeptin, which are key components for the biocontrol activity by strain In5 in vitro and in soil microcosm experiments. Furthermore, complex microbial behaviors were highlighted. Whereas nunamycin was demonstrated to inhibit the mycelial growth of R.  solani Ag3, but not that of Pythium aphanidermatum, nunapeptin instead inhibited P.  aphanidermatum but not R.  solani Ag3. Moreover, the synthesis of nunamycin by @entity2 In5 was inhibited in the presence of P.  aphanidermatum. Further characterization of the two peptides revealed nunamycin to be a monochlorinated 9-amino-acid cyclic lipopeptide with similarity to members of the syringomycin group, whereas nunapeptin was a 22-amino-acid cyclic lipopeptide with similarity to corpeptin and syringopeptin. IMPORTANCE: Crop rotation and systematic pest management are used to only a limited extent in Greenlandic @entity1 farming. Nonetheless, although plant-pathogenic fungi are present in the soil, the farmers do not experience major @entity0 outbreaks. Here, we show that a Greenlandic @entity1 soil is suppressive against Rhizoctonia solani, and we unravel the key biocontrol components for @entity2 In5, one of the potent biocontrol bacteria isolated from this Greenlandic suppressive soil. Using a combination of molecular genetics, genomics, and microbial imaging mass spectrometry, we show that two cyclic lipopeptides, nunamycin and nunapeptin, are important for the biocontrol activity of @entity2 In5 both in vitro and in microcosm assays. Furthermore, we demonstrate that the synthesis of nunamycin is repressed by the oomycete Pythium aphanidermatum. Overall, our report provides important insight into interkingdom interference between bacteria and fungi/oomycetes.

title: Nonribosomal Peptides, Key Biocontrol Components for XXXX In5, Isolated from a Greenlandic Suppressive Soil.

answer: @entity2


abstract: Background. @entity2 (AF) is the most common form of @entity1 . Several trials have suggested that acupuncture may prevent AF. However, the efficacy of acupuncture for AF prevention has not been well investigated. Therefore, we designed a prospective, two-parallel-armed, @entity0 and assessor blinded, randomized, sham-controlled clinical trial to investigate acupuncture in persistent AF (ACU-AF). Methods. A total of 80 @entity0 will be randomly assigned to active acupuncture or sham acupuncture groups in a 1   :   1 ratio. Both groups will take the same antiarrhythmic medication during the study period. @entity0 will receive 10 sessions of acupuncture treatment once a week for 10 weeks. The primary endpoint is AF recurrence rate. Secondary endpoints are left atrium (LA) and left atrial appendage (LAA) changes in function and volume, and inflammatory biomarker changes. Ethics. This study protocol was approved by the institutional review boards (IRBs) of Kyung Hee University Hospital (number 1335-04). This trial is registered with clinicaltrials.gov NCT02110537.

title: Acupuncture antiarrhythmic effects on drug refractory persistent XXXX : study protocol for a randomized, controlled trial.

answer: @entity2


abstract: BACKGROUND: To evaluate the application value of a @entity8 ( @entity8 ) in an ileal pouch-anal @entity5 , which is a novel procedure first performed in our hospital in 2008. MATERIALS AND METHODS: Two males cases with @entity1 and one female with @entity7 were treated with colorectal surgery at the First Affiliated Hospital of Zhejiang University since March 2010. The surgery was designed as total proctocolectomy with an ileal pouch-anal @entity5 and @entity8 . The surgical plan and procedure was determined with the @entity0 after analyzing their hospitalized records and follow-up information. RESULTS: No operation-induced @entity3 or @entity6 occurred. One @entity0 had a persistent @entity4 and another @entity0 presented with postoperative urinary retention. The average time until @entity9 occurred post- @entity8 was 26 days, and the average time until the removal of the postoperative stomal tube was 46 days that healed well. CONCLUSIONS: An @entity8 can effectively protect the @entity5 with a simple operation and avoid the second surgery. @entity0 with @entity1 require a two-stage operation, those who were in poor health and had a long history of hormone treatment even requiring a three-stage operation. However, a one- or two-stage operation could help alleviate @entity2 for @entity0 who require multiple surgeries and reduce economic burden.

title: Application of a @entity8 in an ileal pouch-anal XXXX : a preliminary study.

answer: @entity5


abstract: BACKGROUND: To evaluate the application value of a @entity8 ( @entity8 ) in an ileal pouch-anal @entity5 , which is a novel procedure first performed in our hospital in 2008. MATERIALS AND METHODS: Two males cases with @entity1 and one female with @entity7 were treated with colorectal surgery at the First Affiliated Hospital of Zhejiang University since March 2010. The surgery was designed as total proctocolectomy with an ileal pouch-anal @entity5 and @entity8 . The surgical plan and procedure was determined with the @entity0 after analyzing their hospitalized records and follow-up information. RESULTS: No operation-induced @entity3 or @entity6 occurred. One @entity0 had a persistent @entity4 and another @entity0 presented with postoperative urinary retention. The average time until @entity9 occurred post- @entity8 was 26 days, and the average time until the removal of the postoperative stomal tube was 46 days that healed well. CONCLUSIONS: An @entity8 can effectively protect the @entity5 with a simple operation and avoid the second surgery. @entity0 with @entity1 require a two-stage operation, those who were in poor health and had a long history of hormone treatment even requiring a three-stage operation. However, a one- or two-stage operation could help alleviate @entity2 for @entity0 who require multiple surgeries and reduce economic burden.

title: Application of a XXXX in an ileal pouch-anal @entity5 : a preliminary study.

answer: @entity8


abstract: Introduction. Several laparoscopic treatment techniques were designed for improving the outcome over the last decade. The various techniques differ in their approach to the inguinal internal ring, suturing and knotting techniques, number of ports used in the procedures, and mode of dissection of the @entity2 sac. @entity0 and Surgical Technique. 90 @entity0 were subjected to surgery and they undergone two-port laparoscopic repair of @entity1 in @entity0 . Technique feasibility in relation to other modalities of repair was the aim of this work. 90 @entity0 including 75 males and 15 females underwent surgery. @entity2 in 55 cases was right-sided and in 15 left-sided. Two @entity0 had recurrent @entity2 following open @entity2 repair. 70 (77.7%) cases were suffering unilateral @entity2 and 20 (22.2%) @entity0 had @entity2 . Out of the 20 cases 5 cases were diagnosed by laparoscope (25%). The @entity0 ' median age was 18 months. The mean operative time for unilateral repairs was 15 to 20 minutes and bilateral was 21 to 30 minutes. There was no conversion. The complications were as follows: one case was recurrent @entity1 and the second was stitch sinus. Discussion. The results confirm the safety and efficacy of two ports laparoscopic @entity2 repair in @entity1 in relation to other modalities of treatment.

title: Two ports laparoscopic XXXX repair in @entity0 .

answer: @entity1


abstract: Introduction. Several laparoscopic treatment techniques were designed for improving the outcome over the last decade. The various techniques differ in their approach to the inguinal internal ring, suturing and knotting techniques, number of ports used in the procedures, and mode of dissection of the @entity2 sac. @entity0 and Surgical Technique. 90 @entity0 were subjected to surgery and they undergone two-port laparoscopic repair of @entity1 in @entity0 . Technique feasibility in relation to other modalities of repair was the aim of this work. 90 @entity0 including 75 males and 15 females underwent surgery. @entity2 in 55 cases was right-sided and in 15 left-sided. Two @entity0 had recurrent @entity2 following open @entity2 repair. 70 (77.7%) cases were suffering unilateral @entity2 and 20 (22.2%) @entity0 had @entity2 . Out of the 20 cases 5 cases were diagnosed by laparoscope (25%). The @entity0 ' median age was 18 months. The mean operative time for unilateral repairs was 15 to 20 minutes and bilateral was 21 to 30 minutes. There was no conversion. The complications were as follows: one case was recurrent @entity1 and the second was stitch sinus. Discussion. The results confirm the safety and efficacy of two ports laparoscopic @entity2 repair in @entity1 in relation to other modalities of treatment.

title: Two ports laparoscopic @entity1 repair in XXXX .

answer: @entity0


abstract: The @entity2 is produced by the epithelium of the ciliary body, a complex structure encircling the anterior segment of the eye. @entity2 production occurs by active transport, but the mechanism of this process is not understood. To produce a preparation in which active transport can be investigated, we have attempted to prepare cultures suitable for measurements of ion and water flux. We have grown @entity0 ciliary body epithelial cells on permeable supports, coated with several extracellular matrix proteins. We then examined the ability of these proteins to promote the growth of a differentiated layer of epithelial cells. Non-pigmented and pigmented cells formed sheets of contiguous cells when grown on a variety of support media. The most successful substrate was a permeable support produced by @entity3 with a mixture of collagen IV, laminin and heparan @entity1 . Under these conditions, cultures could be maintained for several months, but pigmented cell cultures did not develop a measurable transepithelial resistance (TER), and the TER of non-pigmented cell cultures was typically only 20-30 omega cm2. Much higher TERs exceeding 200 omega cm2 could be measured from non-pigmented cell cultures 3-5 days after plating, but these high values were unstable. Examination of the cultures with electron microscopy revealed that the cells were partially differentiated with the formation of a basal lamina and intercellular junctions. Labelling with a specific monoclonal antibody marker for tight junction protein (ZO-1) suggested that non-pigmented cell cultures showed extensive tight junction formation. The low TER of the non-pigmented cell cultures appears therefore not to be due to the lack of tight junctions but rather to the presence of spaces between cells.

title: Tissue culture of XXXX ciliary body epithelial cells on permeable supports.

answer: @entity0


abstract: 1. The effects of the volatile anesthetics @entity5 , @entity4 , and @entity6 on @entity3 ( @entity3 ) receptor-mediated inhibitory postsynaptic currents (IPSCs) were studied in cultured @entity0 hippocampal neurons. The experimental concentrations of anesthetics were measured directly using gas chromatography. All three anesthetics increased the overall duration of IPSCs, measured as the time to half-decay (T1/2). Clinically effective concentrations of anesthetics [between 0.5 and 1.5 times MAC (minimum alveolar concentration)] produced between 100 and 400% increases in T1/2. These effects were fully reversible, and did not involve alterations in the reversal potential for the IPSC (EIPSC). 2. The decay of the IPSC was fitted as a sum of two exponential functions, yielding a fast component (tau fast = 20 ms), and a slow component (tau slow = 77 ms), such that the fast component accounted for 79% of the IPSC amplitude and 52% of the total charge transfer. All three anesthetics produced concentration-related @entity1 , while simultaneously decreasing the amplitude and charge transfer of the fast component. Thus T1/2 approximated tau fast under control conditions, but approximated tau slow in the presence of the anesthetics. 3. Varying the @entity2 chelating agents in the recording pipettes had no effect on the quality or magnitude of alterations in IPSC kinetics produced by @entity4 , suggesting that variations in intracellular @entity2 levels are not required for the effect of @entity4 on the time course of the IPSC. 4. The (+)-stereoisomer of @entity6 produced greater increases in the duration of the IPSC than the (-)-isomer when applied at approximately equal concentrations, suggesting that there is a structurally selective site of interaction for @entity6 that modulates the GABAA receptor. 5. These results suggest that the previously shown abilities of volatile anesthetics to potentiate responses to exogenously applied @entity3 and to prolong the duration of @entity3 -mediated synaptic inhibition may be due to an alteration in the gating kinetics of the GABAA receptor/channel complex. Prolongation of synaptic inhibition in the CNS is consistent with the physiological effects that accompany anesthesia and may contribute to the mechanism of anesthetic action.

title: Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured XXXX hippocampal neurons.

answer: @entity0


abstract: Activation of the vascular endothelium is thought to be an important facet of @entity2 , @entity3 , and @entity4 . Activated endothelial cells express a number of immunologically relevant surface markers not expressed by normal endothelial cells. Many of these surface antigens are thought to augment adhesion reactions and migration. Our results show that endothelial activation may play a central role in the pathogenesis of @entity1 ( @entity1 ). Normal @entity0 central nervous system microvessels isolated from autopsy material do not express endothelial cell activation markers, including the adhesion proteins @entity7 ( @entity7 ) and endothelial cell leukocyte adhesion molecule-1 ( @entity6 / @entity6 ). They exhibit little to no constitutive expression of immunoreactive @entity5 ( @entity5 ) or the @entity8 . Control microvessels exhibit no major histocompatibility complex (MHC) class II antigen. @entity1 microvessels express significant levels of MHC class II antigens, @entity5 , @entity7 , and @entity8 . @entity6 was expressed by 3 of 5 @entity1 brains tested. Histologically unaffected areas of @entity1 brain expressed less @entity7 , @entity5 , and @entity6 than did microvessels from periplaque zones. However, MHC class II antigens and @entity8 were increased in areas exhibiting little to no evidence of leukocyte infiltration. When microvessels were examined for dual expression of activation markers, we found that in periplaque areas, 50% of microvessels coexpressed HLA-DR and @entity7 , 28% of microvessels coexpressed HLA-DR and @entity8 , and 43% of microvessels coexpressed HLA-DR and @entity5 .

title: Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from @entity0 with XXXX .

answer: @entity1


abstract: Activation of the vascular endothelium is thought to be an important facet of @entity2 , @entity3 , and @entity4 . Activated endothelial cells express a number of immunologically relevant surface markers not expressed by normal endothelial cells. Many of these surface antigens are thought to augment adhesion reactions and migration. Our results show that endothelial activation may play a central role in the pathogenesis of @entity1 ( @entity1 ). Normal @entity0 central nervous system microvessels isolated from autopsy material do not express endothelial cell activation markers, including the adhesion proteins @entity7 ( @entity7 ) and endothelial cell leukocyte adhesion molecule-1 ( @entity6 / @entity6 ). They exhibit little to no constitutive expression of immunoreactive @entity5 ( @entity5 ) or the @entity8 . Control microvessels exhibit no major histocompatibility complex (MHC) class II antigen. @entity1 microvessels express significant levels of MHC class II antigens, @entity5 , @entity7 , and @entity8 . @entity6 was expressed by 3 of 5 @entity1 brains tested. Histologically unaffected areas of @entity1 brain expressed less @entity7 , @entity5 , and @entity6 than did microvessels from periplaque zones. However, MHC class II antigens and @entity8 were increased in areas exhibiting little to no evidence of leukocyte infiltration. When microvessels were examined for dual expression of activation markers, we found that in periplaque areas, 50% of microvessels coexpressed HLA-DR and @entity7 , 28% of microvessels coexpressed HLA-DR and @entity8 , and 43% of microvessels coexpressed HLA-DR and @entity5 .

title: Expression of immunologically relevant endothelial cell activation antigens on isolated central nervous system microvessels from XXXX with @entity1 .

answer: @entity0