abstract: Perfluorochemicals ( @entity9 -43) is characterized with its small size and high propensity for carrying @entity2 and @entity6 , and also have the function to improve the cerebral microcirculation. These characteristic features of @entity9 -43 may have a beneficial effect on @entity7 chemotherapy in terms of the oxygenation of @entity5 cells, and/or the improvement of the pharmacokinetics of anticancer drugs. This study was undertaken to identify the combined effect of perfluorochemicals ( @entity9 -43, 20 ml/kg) and chemotherapeutic agent ( @entity8 , LD10 dose; 13.3 mg/kg) in a @entity3 @entity7 model. @entity7 model was made by the intracerebral implantation of C6 @entity3 @entity1 cells (1 X 10(5) cells/10 microliters). At 10 days after implantation, control animals had a macrotumor weighing about 100 mg with large part of central @entity4 . The @entity0 -bearing @entity3 for 10 days after implantation were randomly divided into 4 groups; a control group, a @entity9 -43 treatment group, a @entity8 treatment group, and a @entity9 -43 plus @entity8 treatment group. Control animals had mean survival time of 19.94 +/- 2.41 (S.D.) days, and mean survival time of @entity9 -43 treatment group was 19.47 +/- 1.36 days. @entity8 treatment alone prolonged the mean survival time to 28.36 +/- 7.94 days (p less than 0.001). @entity9 -43 plus @entity8 treatment group showed 36.00 +/- 10.15 days, which was significantly greater than that of @entity8 treatment alone group (p less than 0.005). The long survivals lived over 50 days after implantation were 7 out of 27 @entity3 in @entity9 -43 plus @entity8 treatment group, in contrast to one out of 25 @entity3 in @entity8 treatment alone group. Perfluorochemicals ( @entity9 -43) may have the synergistic effect on @entity8 chemotherapy for @entity7 . It was speculated for the above results that following the oxygenation of @entity5 cells by @entity9 -43, @entity5 cells might be sensitized to @entity8 , which might be much delivered into @entity5 area. And further studies should be done for the evaluation of the mechanism of perfluorochemicals on @entity7 experimentally before clinical application.

title: [Effect of perfluorochemicals on XXXX chemotherapy in a @entity3 @entity7 model].

answer: @entity8


abstract: Perfluorochemicals ( @entity9 -43) is characterized with its small size and high propensity for carrying @entity2 and @entity6 , and also have the function to improve the cerebral microcirculation. These characteristic features of @entity9 -43 may have a beneficial effect on @entity7 chemotherapy in terms of the oxygenation of @entity5 cells, and/or the improvement of the pharmacokinetics of anticancer drugs. This study was undertaken to identify the combined effect of perfluorochemicals ( @entity9 -43, 20 ml/kg) and chemotherapeutic agent ( @entity8 , LD10 dose; 13.3 mg/kg) in a @entity3 @entity7 model. @entity7 model was made by the intracerebral implantation of C6 @entity3 @entity1 cells (1 X 10(5) cells/10 microliters). At 10 days after implantation, control animals had a macrotumor weighing about 100 mg with large part of central @entity4 . The @entity0 -bearing @entity3 for 10 days after implantation were randomly divided into 4 groups; a control group, a @entity9 -43 treatment group, a @entity8 treatment group, and a @entity9 -43 plus @entity8 treatment group. Control animals had mean survival time of 19.94 +/- 2.41 (S.D.) days, and mean survival time of @entity9 -43 treatment group was 19.47 +/- 1.36 days. @entity8 treatment alone prolonged the mean survival time to 28.36 +/- 7.94 days (p less than 0.001). @entity9 -43 plus @entity8 treatment group showed 36.00 +/- 10.15 days, which was significantly greater than that of @entity8 treatment alone group (p less than 0.005). The long survivals lived over 50 days after implantation were 7 out of 27 @entity3 in @entity9 -43 plus @entity8 treatment group, in contrast to one out of 25 @entity3 in @entity8 treatment alone group. Perfluorochemicals ( @entity9 -43) may have the synergistic effect on @entity8 chemotherapy for @entity7 . It was speculated for the above results that following the oxygenation of @entity5 cells by @entity9 -43, @entity5 cells might be sensitized to @entity8 , which might be much delivered into @entity5 area. And further studies should be done for the evaluation of the mechanism of perfluorochemicals on @entity7 experimentally before clinical application.

title: [Effect of perfluorochemicals on @entity8 chemotherapy in a @entity3 XXXX model].

answer: @entity7


abstract: Perfluorochemicals ( @entity9 -43) is characterized with its small size and high propensity for carrying @entity2 and @entity6 , and also have the function to improve the cerebral microcirculation. These characteristic features of @entity9 -43 may have a beneficial effect on @entity7 chemotherapy in terms of the oxygenation of @entity5 cells, and/or the improvement of the pharmacokinetics of anticancer drugs. This study was undertaken to identify the combined effect of perfluorochemicals ( @entity9 -43, 20 ml/kg) and chemotherapeutic agent ( @entity8 , LD10 dose; 13.3 mg/kg) in a @entity3 @entity7 model. @entity7 model was made by the intracerebral implantation of C6 @entity3 @entity1 cells (1 X 10(5) cells/10 microliters). At 10 days after implantation, control animals had a macrotumor weighing about 100 mg with large part of central @entity4 . The @entity0 -bearing @entity3 for 10 days after implantation were randomly divided into 4 groups; a control group, a @entity9 -43 treatment group, a @entity8 treatment group, and a @entity9 -43 plus @entity8 treatment group. Control animals had mean survival time of 19.94 +/- 2.41 (S.D.) days, and mean survival time of @entity9 -43 treatment group was 19.47 +/- 1.36 days. @entity8 treatment alone prolonged the mean survival time to 28.36 +/- 7.94 days (p less than 0.001). @entity9 -43 plus @entity8 treatment group showed 36.00 +/- 10.15 days, which was significantly greater than that of @entity8 treatment alone group (p less than 0.005). The long survivals lived over 50 days after implantation were 7 out of 27 @entity3 in @entity9 -43 plus @entity8 treatment group, in contrast to one out of 25 @entity3 in @entity8 treatment alone group. Perfluorochemicals ( @entity9 -43) may have the synergistic effect on @entity8 chemotherapy for @entity7 . It was speculated for the above results that following the oxygenation of @entity5 cells by @entity9 -43, @entity5 cells might be sensitized to @entity8 , which might be much delivered into @entity5 area. And further studies should be done for the evaluation of the mechanism of perfluorochemicals on @entity7 experimentally before clinical application.

title: [Effect of perfluorochemicals on @entity8 chemotherapy in a XXXX @entity7 model].

answer: @entity3


abstract: Platelet-associated IgG (PAIgG), platelet @entity4 ( @entity4 ), and platelet sequestration sites were studied in 69 @entity0 with immune ( @entity2 ) and presumed nonimmune @entity1 (NTP). A shortened @entity4 was associated with elevated PAIgG (N = 46), and with normal PAIgG (N = 15). Four @entity0 had a normal @entity4 , but elevated PAIgG, four @entity0 were normal for both parameters. The highest PAIgG values occurred in @entity2 @entity0 with a very short @entity4 . Nine NTP @entity0 had also elevated PAIgG, but a normal or slightly shortened @entity4 . There was a significant double log correlation between PAIgG and @entity4 for @entity2 , but not for NTP @entity0 . Judged from the coefficient of determination, only 10% of PAIgG were directly related to a shortened @entity4 . 70% of @entity0 (N = 63) had exclusively @entity3 and 30% hepatosplenic sequestration. PAIgG was elevated in 29/44 @entity0 with @entity3 (66%) and in 16/19 @entity0 with hepatosplenic sequestration (84%). In @entity2 , PAIgG-positive cases were observed in 69% of @entity3 v 82% of hepatosplenic sequestration, while in NTP the corresponding figures were 6/11 and 2/2. No significant correlation between PAIgG and either sequestration type was demonstrable. We conclude that in immunologically mediated @entity1 only a small portion of PAIgG accounts for a decreased @entity4 , and that the concentration of PAIgG per se does not determine the platelet sequestration type.

title: Platelet associated IgG, platelet survival, and platelet sequestration in XXXX states.

answer: @entity1


abstract: The effects of castration on the synthesis (accumulation) of a major seminal vesicle secretory protein ( @entity3 ) were examined in young adult @entity0 . In vitro incorporation of labeled @entity2 into @entity3 by minced tissue was monitored by immunological methods. Castration resulted in a large decrease in the differential synthesis of @entity3 . A significant decrease in the relative incorporation of isotope into @entity3 was evident within 3 days of castration, and by 4 weeks relative incorporation dropped some 30-fold. These changes took place in the presence of a large generalized decline in protein synthesis so that incorporation into @entity3 on an organ basis decreased by over 200-fold. @entity3 messenger RNA levels were estimated by RNA excess solution hybridization using a cloned cDNA probe. Relative message levels declined after castration in harmony with the declines in @entity3 synthesis. @entity3 mRNA was decreased by a relative factor of approximately 20 and an absolute factor of approximately 200 in long-term (40-day) castrates. Accordingly, the seminal vesicle conforms to the general pattern of @entity1 regulated systems in which hormone withdrawal leads to differential decreases in the steady-state pool size for specific mRNAs. The seminal vesicle is unusual, however, in that a prolonged period is required for maximum differential effects to occur.

title: Effect of castration on the synthesis of seminal vesicle secretory protein IV in the XXXX .

answer: @entity0


abstract: BACKGROUND: Recent studies have indicated that @entity5 is an etiologic agent for a subset of @entity2 associated with better prognosis, therefore, prompt confirmation of such etiology seems to be crucial for choosing the optimal therapeutic option. Standard HPV diagnosis is currently based on histopathological material. In the present study, the novel diagnostic method based on pharyngeal brush biopsy is proposed. OBJECTIVES: The aim of this study was to evaluate the usefulness of the Real-Time PCR-based (RT-PCR) test in detecting HPV-related @entity1 of the oropharynx using superficial scraps taken from the oropharyngeal region. STUDY DESIGN: Ninety @entity0 with head and neck @entity6 were enrolled in the study. The presence of HPV DNA in pharyngeal superficial scrapes assessed by RT-PCR was compared to the HPV status in the @entity1 tissue samples determined by a combined RT-PCR/ @entity4 ( @entity4 ) expression algorithm. Analytical sensitivity and specificity were calculated and the clinical outcome was analyzed in correlation to the HPV status. RESULTS: HR-HPV DNA in pharyngeal swabs was revealed in 25 cases (28.4%) and simultaneously confirmed in all corresponding tissue samples. Sensitivity and specificity of the viral status assessment in the brush biopsies in respect to the RT-PCR/ @entity4 ( @entity4 ) 20 were 100% and 96.2%, respectively. HR-HPV positive status was associated with an excellent clinical outcome and reduced hazard ratio of recurrence and @entity3 . CONCLUSIONS: The proposed novel method of HPV status assessment using RT-PCR and superficial scraps appeared to be highly sensitive, specific, and useful in predicting the clinical outcome.

title: XXXX DNA in pharyngeal scrapes as a marker of HPV-related @entity6 of the oropharynx.

answer: @entity5


abstract: BACKGROUND: Recent studies have indicated that @entity5 is an etiologic agent for a subset of @entity2 associated with better prognosis, therefore, prompt confirmation of such etiology seems to be crucial for choosing the optimal therapeutic option. Standard HPV diagnosis is currently based on histopathological material. In the present study, the novel diagnostic method based on pharyngeal brush biopsy is proposed. OBJECTIVES: The aim of this study was to evaluate the usefulness of the Real-Time PCR-based (RT-PCR) test in detecting HPV-related @entity1 of the oropharynx using superficial scraps taken from the oropharyngeal region. STUDY DESIGN: Ninety @entity0 with head and neck @entity6 were enrolled in the study. The presence of HPV DNA in pharyngeal superficial scrapes assessed by RT-PCR was compared to the HPV status in the @entity1 tissue samples determined by a combined RT-PCR/ @entity4 ( @entity4 ) expression algorithm. Analytical sensitivity and specificity were calculated and the clinical outcome was analyzed in correlation to the HPV status. RESULTS: HR-HPV DNA in pharyngeal swabs was revealed in 25 cases (28.4%) and simultaneously confirmed in all corresponding tissue samples. Sensitivity and specificity of the viral status assessment in the brush biopsies in respect to the RT-PCR/ @entity4 ( @entity4 ) 20 were 100% and 96.2%, respectively. HR-HPV positive status was associated with an excellent clinical outcome and reduced hazard ratio of recurrence and @entity3 . CONCLUSIONS: The proposed novel method of HPV status assessment using RT-PCR and superficial scraps appeared to be highly sensitive, specific, and useful in predicting the clinical outcome.

title: @entity5 DNA in pharyngeal scrapes as a marker of HPV-related XXXX of the oropharynx.

answer: @entity6


abstract: BACKGROUND: The novel @entity2 H1N1 (A[H1N1]pdm09) strain emerged in 2009, contributing to significant morbidity and mortality. It is not known whether illness associated with A(H1N1) pdm09 in the post-pandemic era exhibits a similar disease profile. OBJECTIVE: The objectives of this study were to compare the burden of disease of A(H1N1) pdm09 @entity2 from the 2009 pandemic year to the post-pandemic years (2010-2014), and to explore potential reasons for any differences. STUDY DESIGN: We conducted a retrospective cohort study of inpatients admitted to @entity0 's Hospital Colorado with a positive respiratory specimen for @entity2 from May-December, 2009 and December, 2010-April, 2014. Univariate and multivariate analyses were conducted to compare the demographics and clinical characteristics of @entity0 with H1N1 during the two periods. RESULTS: There were 388 inpatients with @entity2 (H1N1) pdm09 in 2009, and 117 during the post-pandemic years. Ninety-four percent of all H1N1 during the post-pandemic era was observed during the 2013-2014 @entity2 season. @entity0 with A(H1N1) pdm09 during the post-pandemic year were less likely to have an underlying medical condition (P<0.01). @entity0 admitted to the ICU during the post-pandemic year had a lower median age (5 vs 8 years, P=0.01) and a lower proportion of @entity0 were intubated, had mental status changes, and @entity1 compared with the pandemic years, (P<0.01 for all), with decreased mortality (P=0.02). CONCLUSION: @entity0 with @entity2 (H1N1) pdm09 during the post-pandemic years appeared to have less severe disease than @entity0 with A(H1N1) pdm09 during the pandemic year. The reasons for this difference are likely multifactorial.

title: A comparison of H1N1 XXXX among pediatric inpatients in the pandemic and post pandemic era.

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to evaluate whether there are clinical subgroups that may have different prognoses among @entity3 @entity0 . METHODS: The cumulative clinical features of a large group of @entity3 @entity0 [1168 @entity0 , 593 (50.8%) male, mean age 35.3 years (s.d. 12.4)] were studied. To analyse our data and identify groups of @entity3 @entity0 with similar clinical characteristics, a two-step cluster analysis using log-likelihood distance measures was performed. For clustering the @entity3 @entity0 , we evaluated the following variables: gender, current age, age at symptom onset, age at diagnosis, presence of major clinical features, variables related with therapy and family history for @entity3 , @entity1 and carriage of @entity9 . RESULTS: Three distinct groups of @entity3 @entity0 were identified. Cluster 1 was characterized by a high prevalence of @entity2 , @entity7 , @entity8 -like erythema (ELE) and @entity4 . The dosage of @entity6 and the frequency of @entity5 were lower in cluster 1. @entity0 in cluster 2 had an earlier age of disease onset and diagnosis. @entity9 carriage and @entity5 prevalence were the highest in cluster 2. This group of @entity0 was using the highest dose of @entity6 . @entity0 in cluster 3 had the lowest prevalence of @entity2 , ELE and @entity4 . The frequencies of @entity9 carriage and @entity5 were lower in cluster 3 than the overall @entity3 @entity0 . Non-response to @entity6 was also slightly lower in cluster 3. CONCLUSION: @entity0 with @entity3 can be clustered into distinct patterns of clinical and genetic manifestations and these patterns may have different prognostic significance.

title: Different disease subtypes with distinct clinical expression in XXXX : results of a cluster analysis.

answer: @entity3


abstract: UNASSIGNED: In this study, the prevalence of @entity4 ( @entity4 ) and serum sexual hormone levels were evaluated in @entity0 with @entity1 ( @entity1 ). In these @entity0 , the efficacy of continuous positive airway pressure (CPAP) was determined. The 207 @entity0 (mean age 44.0      11.1  years) enrolled in the study were stratified within four groups based on their @entity1 index score: simple snoring (n  =  32), mild @entity1 (n  =  29), moderate @entity1 (n  =  38), and severe @entity1 (n  =  108). The International Index of @entity4 -5 (IIEF-5) score was obtained from each @entity0 , and blood samples for the analysis of sexual hormones (prolactin, luteotropin, follicle-stimulating hormone, @entity2 , @entity5 , and @entity3 ) were drawn in the morning after polysomnography. The IIEF-5 test and serum sexual hormone measurements were repeated after 3  months of CPAP treatment in 53 @entity0 with severe @entity1 . The prevalence of @entity4 was 60.6  % in @entity1 @entity0 overall and 72.2  % in those with severe @entity1 . Compared with the simple snoring group, @entity0 with severe @entity1 had significantly lower @entity3 levels (14.06      5.62 vs. 17.02      4.68, p  =  .018) and lower IIEF-5 scores (16.33      6.50 vs. 24.09      1.94, p  =  .001). The differences in the other sexual hormones between groups were not significant. After 3  months of CPAP treatment, there were no significant changes in sexual hormone levels, but the IIEF-5 score had improved significantly (18.21      4.05 vs. 19.21      3.86, p  =  .001). Severe @entity1 @entity0 have low @entity3 concentration and high @entity4 prevalence. IIEF-5 scores increased significantly after CPAP treatment, but there was no effect on serum @entity3 levels.

title: XXXX and Sexual Hormone Levels in @entity0 With Obstructive Sleep Apnea: Efficacy of Continuous Positive Airway Pressure.

answer: @entity4


abstract: UNASSIGNED: In this study, the prevalence of @entity4 ( @entity4 ) and serum sexual hormone levels were evaluated in @entity0 with @entity1 ( @entity1 ). In these @entity0 , the efficacy of continuous positive airway pressure (CPAP) was determined. The 207 @entity0 (mean age 44.0      11.1  years) enrolled in the study were stratified within four groups based on their @entity1 index score: simple snoring (n  =  32), mild @entity1 (n  =  29), moderate @entity1 (n  =  38), and severe @entity1 (n  =  108). The International Index of @entity4 -5 (IIEF-5) score was obtained from each @entity0 , and blood samples for the analysis of sexual hormones (prolactin, luteotropin, follicle-stimulating hormone, @entity2 , @entity5 , and @entity3 ) were drawn in the morning after polysomnography. The IIEF-5 test and serum sexual hormone measurements were repeated after 3  months of CPAP treatment in 53 @entity0 with severe @entity1 . The prevalence of @entity4 was 60.6  % in @entity1 @entity0 overall and 72.2  % in those with severe @entity1 . Compared with the simple snoring group, @entity0 with severe @entity1 had significantly lower @entity3 levels (14.06      5.62 vs. 17.02      4.68, p  =  .018) and lower IIEF-5 scores (16.33      6.50 vs. 24.09      1.94, p  =  .001). The differences in the other sexual hormones between groups were not significant. After 3  months of CPAP treatment, there were no significant changes in sexual hormone levels, but the IIEF-5 score had improved significantly (18.21      4.05 vs. 19.21      3.86, p  =  .001). Severe @entity1 @entity0 have low @entity3 concentration and high @entity4 prevalence. IIEF-5 scores increased significantly after CPAP treatment, but there was no effect on serum @entity3 levels.

title: @entity4 and Sexual Hormone Levels in XXXX With Obstructive Sleep Apnea: Efficacy of Continuous Positive Airway Pressure.

answer: @entity0


abstract: 1. The molecular mass of @entity1 transcarbamoylase purified from @entity5 germ was found to be 101kDa by @entity3 -density-gradient centrifugation, 103kDa by gel-filtration chromatography and 108kDa by @entity4 -gel electrophoresis. A mean value of 104 +/- 11kDa was obtained by pooling several replicate results from each method. 2. @entity4 -gel electrophoresis in the presence of @entity0 indicated a single size of polypeptide chain of mean molecular mass 37 +/- 4kDa. The ratio of the mean molecular masses of the active and denatured enzymes is 2.8.3. When the active enzyme was covalently cross-linked at a low protein concentration by @entity6 , and then examined electrophoretically under denaturing conditions, three size species were observed to predominate, of apparent molecular masses 36, 77 and 106kDa respectively. 4. These results indicate that the intact, fully regulatory enzyme is a simple trimer, slightly larger than the trimeric "catalytic subunit' of the @entity1 transcarbamoylase from @entity2 [Weber (1968) Nature (London) 218, 1116-1118]. The prevalence of trimeric structures amongst @entity7 -transferase enzymes is discussed.

title: The quaternary structure of @entity5 -germ XXXX transcarbamoylase.

answer: @entity1


abstract: 1. The molecular mass of @entity1 transcarbamoylase purified from @entity5 germ was found to be 101kDa by @entity3 -density-gradient centrifugation, 103kDa by gel-filtration chromatography and 108kDa by @entity4 -gel electrophoresis. A mean value of 104 +/- 11kDa was obtained by pooling several replicate results from each method. 2. @entity4 -gel electrophoresis in the presence of @entity0 indicated a single size of polypeptide chain of mean molecular mass 37 +/- 4kDa. The ratio of the mean molecular masses of the active and denatured enzymes is 2.8.3. When the active enzyme was covalently cross-linked at a low protein concentration by @entity6 , and then examined electrophoretically under denaturing conditions, three size species were observed to predominate, of apparent molecular masses 36, 77 and 106kDa respectively. 4. These results indicate that the intact, fully regulatory enzyme is a simple trimer, slightly larger than the trimeric "catalytic subunit' of the @entity1 transcarbamoylase from @entity2 [Weber (1968) Nature (London) 218, 1116-1118]. The prevalence of trimeric structures amongst @entity7 -transferase enzymes is discussed.

title: The quaternary structure of XXXX -germ @entity1 transcarbamoylase.

answer: @entity5


abstract: The common @entity4 are prevalent throughout the world, in countries of high technology and among the primitive races. These same @entity6 were described 200 years ago, @entity8 5,000 years ago. Their recent increase is directly related to the advent of cardiac treatment. Most @entity4 known to @entity0 occur in the @entity3 . The prevalence rate of these @entity6 is the same in the @entity3 and in @entity0 (5-8/1,000). Several of the @entity6 are heritable in specific breeds of @entity3 , one in @entity2 , another in @entity1 . These @entity6 occur in various animals that cannot interbreed. Hence the deoxyribonucleic acid (DNA) that codes these @entity6 must lie in that portion of the DNA common to all mammals. This suggests that these @entity6 occurred during the evolution of the @entity0 . Mammals evolved from reptiles, animals with hearts of various structures for the @entity5 . Although the "normal" heart is the most compatible with @entity0 life and hence the most common, some mammals may have evolved with a heart with different structures for the @entity5 . Some of these hearts have persisted. These primeval hearts we call @entity4 of the cyanotic group. Malformations that apparently are arrests in the development of the normal heart ( @entity7 , atrioventricular canal) may represent stages in the evolution of the "normal" heart. Although teratogens and mutagens do exist, the author conceives of @entity4 not as arrests or errors in the development of a "normal" heart but as genetic variants.

title: World survey of the common XXXX : developmental error or genetic variant?

answer: @entity4


abstract: Perforation of an @entity2 can occur spontaneously or during radiotherapy. If the perforation is the first manifestation of the @entity1 , the diagnosis depends on X-ray and endoscopy. During radiotherapy, the intending perforation must be carefully watched for. We have treated two perforations appearing as first manifestation of the @entity1 and 3 developed during evolution, 2 of them during radiotherapy. Various treatments have been applied. In 2 cases, resection was possible, curative in one, palliative in the other. In the other 3 cases, retrosternal by-pass has allowed feeding and radiotherapy. Such a complication generally condemns the @entity0 to a gastrostomy. However, a more aggressive surgical attitude can be adopted if the general status of the @entity0 permits. An esophageal endo-prosthesis can also be used.

title: [Perforation of XXXX (author's transl)].

answer: @entity2


abstract: Non-bullous @entity9 (NBCIE) is a @entity1 caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte differentiation. Impaired function of these enzymes can cause pathologic epidermal scaling, significantly reduced skin barrier function. In this study, we have performed a focused, genetic analysis of a probrand affected by NBCIE and extended this to his consanguineous parents. Targeted capture and next-generation sequencing was performed on NBCIE associated genes in the proband and his unaffected consanguineous parents. We identified a homozygous nonsense variant @entity10 (p.Arg272*) in @entity11 (NM_001165960.1) in the proband and discovered that his parents are both heterozygous carriers of the variant. The clinical manifestations of the proband's skin were consistent with NBCIE, and detailed histopathological assessment revealed @entity6 formation and @entity3 . Infection with @entity8 was confirmed by culture. The @entity0 responded to oral @entity7 antifungal treatment. Decreased skin barrier function, such as that caused by @entity1 of keratinization, can increase the risk of severe cutaneous @entity2 and the formation of @entity3 and associated @entity4 . @entity0 with NBCIE should be alerted to the possible predisposition for developing @entity5 and warrant close clinical follow-up.

title: Homozygous @entity11 Nonsense Variant Identified in a @entity0 with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous XXXX : The Consequences of Skin Barrier Dysfunction.

answer: @entity3


abstract: Non-bullous @entity9 (NBCIE) is a @entity1 caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte differentiation. Impaired function of these enzymes can cause pathologic epidermal scaling, significantly reduced skin barrier function. In this study, we have performed a focused, genetic analysis of a probrand affected by NBCIE and extended this to his consanguineous parents. Targeted capture and next-generation sequencing was performed on NBCIE associated genes in the proband and his unaffected consanguineous parents. We identified a homozygous nonsense variant @entity10 (p.Arg272*) in @entity11 (NM_001165960.1) in the proband and discovered that his parents are both heterozygous carriers of the variant. The clinical manifestations of the proband's skin were consistent with NBCIE, and detailed histopathological assessment revealed @entity6 formation and @entity3 . Infection with @entity8 was confirmed by culture. The @entity0 responded to oral @entity7 antifungal treatment. Decreased skin barrier function, such as that caused by @entity1 of keratinization, can increase the risk of severe cutaneous @entity2 and the formation of @entity3 and associated @entity4 . @entity0 with NBCIE should be alerted to the possible predisposition for developing @entity5 and warrant close clinical follow-up.

title: Homozygous XXXX Nonsense Variant Identified in a @entity0 with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous @entity3 : The Consequences of Skin Barrier Dysfunction.

answer: @entity11


abstract: Non-bullous @entity9 (NBCIE) is a @entity1 caused by pathogenic variants in genes encoding enzymes important to lipid processing and terminal keratinocyte differentiation. Impaired function of these enzymes can cause pathologic epidermal scaling, significantly reduced skin barrier function. In this study, we have performed a focused, genetic analysis of a probrand affected by NBCIE and extended this to his consanguineous parents. Targeted capture and next-generation sequencing was performed on NBCIE associated genes in the proband and his unaffected consanguineous parents. We identified a homozygous nonsense variant @entity10 (p.Arg272*) in @entity11 (NM_001165960.1) in the proband and discovered that his parents are both heterozygous carriers of the variant. The clinical manifestations of the proband's skin were consistent with NBCIE, and detailed histopathological assessment revealed @entity6 formation and @entity3 . Infection with @entity8 was confirmed by culture. The @entity0 responded to oral @entity7 antifungal treatment. Decreased skin barrier function, such as that caused by @entity1 of keratinization, can increase the risk of severe cutaneous @entity2 and the formation of @entity3 and associated @entity4 . @entity0 with NBCIE should be alerted to the possible predisposition for developing @entity5 and warrant close clinical follow-up.

title: Homozygous @entity11 Nonsense Variant Identified in a XXXX with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous @entity3 : The Consequences of Skin Barrier Dysfunction.

answer: @entity0


abstract: UNASSIGNED: Recent studies have demonstrated the protective effect of cytomegalovirus ( @entity5 ) reactivation against relapse after allogeneic hematopoietic stem cell transplantation (HSCT) for adult @entity1 . We assessed the association of @entity5 reactivation, defined as the development of CMV antigenemia (at least 1 pp65 antigen-positive cell per 5.0  *  10(4) WBCs) within 100  days after HSCT, with the risk of relapse in 143 @entity0 with pediatric @entity6 . The median age at HSCT was 7  years, and underlying diseases included @entity2 in 101 @entity0 and @entity6 in 42. The cumulative incidence of @entity5 reactivation at day 100 after HSCT was 45.4%. At a median follow-up of 88  months, @entity0 with @entity5 reactivation had significantly lower 5-year cumulative incidence of relapse compared with @entity0 without @entity5 reactivation. In a multivariate analysis, high-level @entity5 reactivation (>= 10 pp65 antigen-positive cells) was an independent factor associated with reduced relapse. However, @entity5 reactivation was also associated with higher nonrelapse mortality (NRM), mostly caused by @entity3 after grades II to IV @entity4 ( @entity4 ), which resulted in decreased probability of survival. High-level @entity5 reactivation was a risk factor for increased NRM and worse overall survival in multivariate analysis. Although @entity5 reactivation may reduce the risk of relapse after HSCT for pediatric @entity6 , effective management of severe acute @entity4 and better prophylaxis and treatment of @entity3 are required to reduce the incidence of NRM and improve survival. Further studies on pediatric HSCT that include a larger number of @entity0 and more homogenous @entity0 cohorts are desirable.

title: Effect of Cytomegalovirus Reactivation on Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in XXXX .

answer: @entity6


abstract: BACKGROUND: To determine the impact of cervical length (CL) on the clinical outcome of @entity0 undergoing peripartum hysterectomy due to placenta @entity1 /percreta. OBJECTIVE: To assess the association of CL with clinical outcomes in such @entity0 . METHODS: We analyzed the data of @entity0 who were diagnosed with anterior placenta @entity1 /percreta prenatally and subsequently underwent peripartum hysterectomy at our tertiary care institution between 2004 and 2014. The sonographic images and measurements of CL were obtained from prospectively collected database. The duration of operation, units of blood products transfused, and length of stay in the hospital were recorded. @entity0 were stratified according to CL, and receiver-operating characteristics curves were used to determine the cut-off length for identification of @entity0 at high risk of intra-operative difficulty. RESULTS: Sixty-one @entity0 were included in this study. Number of packages of ES were correlated with the the duration of operation (r   = 0.666, p   <   0.001) and the CL (-0.793, p   <   0.001). Number of packages of fresh frozen plasma was significantly correlated with the CL (-0.642, p   <   0.001) and the duration of operation (r   =   0.606, p   <   0.001). Gestational age (AUC   =   0.683, p   =   0.014) and the CL (AUC   =   0.980, p   <   0.014) were significant predictors for the number of ES transfused   >   4 packages. The cut-off value of four packages was determined according to the median level of packages transfused. Optimal cut-off value for the CL to predict transfusion    <=   4 packages was 20.5 with 93% sensitivity and the 99% specificity. CONCLUSIONS: Short cervix appears to be a cause of difficulty in placenta @entity1 /percreta operations. CL may also help in determining the timing of delivery in @entity2 @entity0 .

title: Shorter the cervix, more difficult the XXXX operations.

answer: @entity2


abstract: BACKGROUND: Primary @entity2 ( @entity2 ) often causes nephrotic @entity3 and frequently results in @entity1 and recurrence after kidney transplantation. Recent studies describe soluble urokinase-type plasminogen activator receptor (suPAR) as a circulating factor implicated in @entity2 . METHODS: This single-center study included 12 adult @entity0 with histologically proven primary @entity2 (n = 2) or recurrent @entity2 after transplantation (n = 10). The effect of @entity4 ( @entity4 ) on clinical outcome, suPAR levels, and in vitro podocyte b3-integrin activation was investigated over a median of 11 (6-18) sessions of @entity4 . RESULTS: The course of treatment was monitored in a total of 70 sessions of @entity4 , which partly eliminated suPAR, with a mean reduction of 37    12% of serum concentration per session. However, a substantial rebound was observed between sessions, with suPAR levels reaching 99    22% of the pretreatment levels after a median of 4 days. Podocyte b3-integrin activation dropped significantly after @entity4 but rebounded within 4 days concomitant with a rising suPAR level. In 11 of 12 @entity0 , multimodal treatment (including extensive @entity4 ) reduced @entity3 significantly (from 5.3 [2.0-7.8] to 1.0 [0.4-1.6] g/d), indicating clinical efficacy of the therapy. One @entity0 suffered allograft loss due to @entity2 recurrence. A persisting response was independent of a lasting reduction in the level of total suPAR because there was no sustained significant change in suPAR levels before and after the course of intensified treatment (3814    908 to 3595    521 pg/mL; P = 0.496). CONCLUSIONS: We conclude that multimodal therapy including extensive @entity4 was associated with stabilization of recurrent @entity2 and a temporary lowering of plasma suPAR as well as podocyte b3-integrin activation. Whether a sustained lowering of total suPAR results in further improved outcomes requires additional study.

title: Recurrent Primary XXXX Managed With Intensified Plasma Exchange and Concomitant Monitoring of Soluble Urokinase-Type Plasminogen Activator Receptor-Mediated Podocyte b3-integrin Activation.

answer: @entity2


abstract: PURPOSE: This study was aimed to assess the acute dermatological adverse effect from two distinct RT techniques for @entity0 @entity1 . We compared intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) and conventional radiotherapy followed by sequential boost (CRT-SB). METHODS: The study population was composed of 126 consecutive @entity0 @entity1 treated with breast conserving surgery. Sixty-six @entity1 received IMRT-SIB to 2 dose levels simultaneously. They received 50.4  Gy at 1.8  Gy per fraction to the whole breast and 60.2  Gy at 2.15  Gy per fraction to the @entity2 bed by integral boost. Sixty @entity1 in the CRT-SB group received 50  Gy in 25 fractions to the whole breast followed by a boost irradiation to @entity2 bed in 5-7 fractions to a total dose of 60-64  Gy. Acute @entity3 were documented in agreement with the Common Terminology Criteria for Adverse Events version 3 (CTCAE v.3.0). RESULTS: Ninety-eight @entity1 had grade 1 radiation @entity4 while 14 @entity1 had grade 2. Among those with grade 2, there were 3 @entity1 in IMRT-SIB group (4.5%) while 11 in CRT-SB group (18.3%). (P  =  0.048) There was no @entity1 with higher than grade 2 @entity3 . Three year local control was 99.2%, 3-year disease free survival was 97.5% and 3-year overall survival was 99.2%. CONCLUSIONS: A significant reduction in the severity of @entity5 from IMRT-SIB comparing with CRT-SB is demonstrated.

title: Intensity modulated radiotherapy with simultaneous integrated boost vs. conventional radiotherapy with sequential boost for XXXX - A preliminary result.

answer: @entity0


abstract: @entity3 and @entity1 co-occur at high rates and can be difficult to distinguish from one another. Cross-sectional evidence has demonstrated that whereas all these disorders are characterized by high negative emotion, low positive emotion shows specificity in its associations with @entity3 , @entity1 , and possibly generalized @entity1 . However, it remains unknown whether @entity2 , a personality trait characterized by the tendency to experience low positive emotion over time, prospectively marks risk for the initial development of these disorders. We aimed to help address this gap. Each year for up to 10 waves, @entity0 (n = 627, mean age = 17 years at baseline) completed self-report measures of mood and personality and a structured clinical interview. A latent trait-state decomposition technique was used to model positive emotionality and related personality traits over the first 3 years of the study. Survival analyses were used to test the prospective associations of @entity2 with first onsets of disorders over the subsequent 6-year follow-up among @entity0 with no relevant disorder history. The results showed that @entity2 was a risk marker for @entity3 , @entity1 , and generalized @entity1 , although evidence for its specificity to these disorders versus the remaining @entity1 was inconclusive. Additional analyses revealed that the risk effects were largely accounted for by the overlap of @entity2 with @entity4 . The implications for understanding the role of positive emotionality in @entity3 and @entity1 are discussed.

title: Prospective associations of XXXX with first onsets of @entity3 : Results from a 10-wave latent trait-state modeling study.

answer: @entity2


abstract: @entity3 and @entity1 co-occur at high rates and can be difficult to distinguish from one another. Cross-sectional evidence has demonstrated that whereas all these disorders are characterized by high negative emotion, low positive emotion shows specificity in its associations with @entity3 , @entity1 , and possibly generalized @entity1 . However, it remains unknown whether @entity2 , a personality trait characterized by the tendency to experience low positive emotion over time, prospectively marks risk for the initial development of these disorders. We aimed to help address this gap. Each year for up to 10 waves, @entity0 (n = 627, mean age = 17 years at baseline) completed self-report measures of mood and personality and a structured clinical interview. A latent trait-state decomposition technique was used to model positive emotionality and related personality traits over the first 3 years of the study. Survival analyses were used to test the prospective associations of @entity2 with first onsets of disorders over the subsequent 6-year follow-up among @entity0 with no relevant disorder history. The results showed that @entity2 was a risk marker for @entity3 , @entity1 , and generalized @entity1 , although evidence for its specificity to these disorders versus the remaining @entity1 was inconclusive. Additional analyses revealed that the risk effects were largely accounted for by the overlap of @entity2 with @entity4 . The implications for understanding the role of positive emotionality in @entity3 and @entity1 are discussed.

title: Prospective associations of @entity2 with first onsets of XXXX : Results from a 10-wave latent trait-state modeling study.

answer: @entity3


abstract: BACKGROUND: New strategies to combat the global scourge of @entity4 may be revealed by increased understanding of the mechanisms by which the obligate snail host can resist the schistosome parasite. However, few molecular markers linked to resistance have been identified and characterized in snails. METHODOLOGY/PRINCIPAL FINDINGS: Here we test six independent genetic loci for their influence on resistance to @entity1 PR1 in the 13-16-R1 strain of the snail @entity5 . We first identify a genomic region, RADres, showing the highest differentiation between susceptible and resistant inbred lines among 1611 informative restriction-site associated DNA (RAD) markers, and show that it significantly influences resistance in an independent set of 439 outbred snails. The additive effect of each RADres resistance allele is 2-fold, similar to that of the previously identified resistance gene sod1. The data fit a model in which both loci contribute independently and additively to resistance, such that the odds of @entity0 in homozygotes for the resistance alleles at both loci (13% infected) is 16-fold lower than the odds of @entity0 in snails without any resistance alleles (70% infected). Genome-wide linkage disequilibrium is high, with both sod1 and RADres residing on haplotype blocks >2Mb, and with other markers in @entity3 also showing significant effects on resistance; thus the causal genes within these blocks remain to be demonstrated. Other candidate loci had no effect on resistance, including the Guadeloupe Resistance Complex and three genes (aif, infPhox, and prx1) with immunological roles and expression patterns tied to resistance, which must therefore be trans-regulated. CONCLUSIONS/SIGNIFICANCE: The loci RADres and sod1 both have strong effects on resistance to @entity2 . Future approaches to control @entity4 may benefit from further efforts to characterize and harness this natural genetic variation.

title: Genome-Wide Scan and Test of Candidate Genes in the Snail XXXX Reveal New Locus Influencing Resistance to @entity1 .

answer: @entity5


abstract: BACKGROUND: New strategies to combat the global scourge of @entity4 may be revealed by increased understanding of the mechanisms by which the obligate snail host can resist the schistosome parasite. However, few molecular markers linked to resistance have been identified and characterized in snails. METHODOLOGY/PRINCIPAL FINDINGS: Here we test six independent genetic loci for their influence on resistance to @entity1 PR1 in the 13-16-R1 strain of the snail @entity5 . We first identify a genomic region, RADres, showing the highest differentiation between susceptible and resistant inbred lines among 1611 informative restriction-site associated DNA (RAD) markers, and show that it significantly influences resistance in an independent set of 439 outbred snails. The additive effect of each RADres resistance allele is 2-fold, similar to that of the previously identified resistance gene sod1. The data fit a model in which both loci contribute independently and additively to resistance, such that the odds of @entity0 in homozygotes for the resistance alleles at both loci (13% infected) is 16-fold lower than the odds of @entity0 in snails without any resistance alleles (70% infected). Genome-wide linkage disequilibrium is high, with both sod1 and RADres residing on haplotype blocks >2Mb, and with other markers in @entity3 also showing significant effects on resistance; thus the causal genes within these blocks remain to be demonstrated. Other candidate loci had no effect on resistance, including the Guadeloupe Resistance Complex and three genes (aif, infPhox, and prx1) with immunological roles and expression patterns tied to resistance, which must therefore be trans-regulated. CONCLUSIONS/SIGNIFICANCE: The loci RADres and sod1 both have strong effects on resistance to @entity2 . Future approaches to control @entity4 may benefit from further efforts to characterize and harness this natural genetic variation.

title: Genome-Wide Scan and Test of Candidate Genes in the Snail @entity5 Reveal New Locus Influencing Resistance to XXXX .

answer: @entity1


abstract: OBJECTIVES: Diagnosis of @entity7 ( @entity7 ) in @entity0 presenting with chronic @entity4 is challenging and controversial. Contrast-enhanced magnetic resonance imaging (MRI) with @entity6 -stimulated MRCP (sMRCP) offers a safe and noninvasive modality to diagnose mild @entity5 , but its findings have not been correlated with histopathology. We aimed to assess the correlation of a spectrum of MRI/sMRCP findings with surgical histopathology in a cohort of @entity7 @entity0 undergoing @entity3 ( @entity3 ). METHODS: Adult @entity0 undergoing @entity3 for @entity7 between 2008 and 2013 were identified from our institution's surgery database and were included if they had MRI/sMRCP within a year before surgery. Histology was obtained from resected pancreas at the time of @entity3 by wedge biopsy of head, body, and tail, and was graded by a gastrointestinal pathologist who was blinded to the imaging features. A @entity1 score (FS) of 2 or more was considered as abnormal, with FS >= 6 as severe @entity1 . A multivariate regression analysis was performed for MRI features predicting @entity1 , after taking age, sex, smoking, @entity2 , and body mass index (BMI) into consideration. A quantitative receiver operating characteristic (ROC) curve analysis was performed and Spearman rank correlation coefficient (r) was calculated. RESULTS: Fifty-seven @entity0 (females=49, males=8) with @entity7 and MRI/sMRCP were identified. ROC curve analysis showed that two or more MRI/sMRCP features provided the best balance of sensitivity (65%), specificity (89%), and accuracy (68%) to differentiate abnormal (FS>= 2) from normal pancreatic tissue. Two or more features provided the best cutoff (sensitivity 88%, specificity 78%) for predicting severe @entity1 (FS>= 6). There was a significant correlation between the number of features and severity of @entity1 (r=0.6, P<0.0001). A linear regression after taking age, smoking, and BMI into consideration showed that main pancreatic duct irregularity, T1-weighted signal intensity ratio between pancreas and paraspinal muscle, and duodenal filling after @entity6 injection to be significant independent predictors of @entity1 . CONCLUSIONS: A strong correlation exists between MRI/sMRCP findings and histopathology of @entity7 .

title: Diagnostic Performance of Contrast-Enhanced MRI With XXXX -Stimulated MRCP for Non-Calcific Chronic Pancreatitis: A Comparison With Histopathology.

answer: @entity6


abstract: The perisomatic retrograde reactions to @entity5 during postnatal maturation were investigated by quantitative light and electron microscopy. The hypoglossal nerve was crushed, ligated or transected in 10 and 21 day postnatal (dpn) @entity1 . Only @entity3 was made in 7 dpn @entity1 . Survival periods ranged from 3 to 40 days postoperative (dpo). Normal and sham operated animals of corresponding ages served as controls. A remarkable, transient response of neuronal somata in the young (7-10 dpn) @entity1 , following all three types of @entity0 , was the formation of excrescences which engulfed neuronal processes: boutons, dendrites, small neurites and a few myelinated axons in adjacent neuropil. The somal engulfment was rarely evident after @entity2 to 21 dpn @entity1 . Bouton displacement from the somal surface, accompanied by glial incursion, followed each @entity2 but was less extensive and occurred later in the young @entity1 . There seemed to be no association in the amount of boutons displaced from neuronal somata with the @entity2 for any of the three experimental age groups. However, the rate and intensity of the perineuronal glial reaction were related to the severity of the @entity2 in the older (21 dpn) but not in the younger (7-10 dpn) @entity1 . Substantial loss of neurons occurred in the affected nucleus after each type of @entity3 to the young neurons. The degree of @entity4 was related to the age and the volume of axoplasm disrupted. Only nerve transection in 21 dpn @entity1 resulted in appreciable @entity4 . The responses of axotomized neurons, their afferent axon terminals and the surrounding glia are quantitatively and qualitatively different in the hypoglossal nucleus of @entity1 of increasing postnatal ages.

title: Perisomatic changes in the maturing hypoglossal nucleus after XXXX .

answer: @entity0


abstract: Isoenergetic diets containing casein: @entity3 :fat, 22:59:10% (control protein, CP), or 8:73:10% (low protein, LP), were fed to female @entity1 during gestation and lactation and to offspring postweaning. Control fed @entity1 were pair-fed to the LP-fed group. In the LP-fed group, body and liver weights were similar at birth but decreased at 10, 21, and 42 days, while intercapsular brown adipose tissue (IBAT) weight decreased from birth to 10 and 21 days but increased at 42 days compared to controls. Hepatic mitochondrial @entity0 consumption (OC) with @entity5 + @entity7 as substrate was similar at 21 and 42 days, whereas OC in state 3 and 4 with @entity6 was decreased at 42 days, only in the LP-fed group. In IBAT, OC was similar in each group at each age. In the LP-fed group, hepatic @entity8 (GP) shuttle activity was the same as in controls at birth but increased progressively from 10 to 21 and 42 days, whereas @entity7 - @entity2 (M-A) shuttle activity was not substantially changed during development. In IBAT, shuttle activities were similar in both groups during development with M-A shuttle activity increased in the LP-fed group at 21 days. Serum @entity4 (T3) levels in the LP-fed group were increased at 10 and 42 days but decreased at 21 days after birth. These results suggest a role for both pre- and postweaning diet composition as a regulator of hepatic metabolism during development. The deficit in IBAT weight in the LP-fed group during early postnatal development indicates a decreased capacity for heat production in the neonate caused by maternal protein undernutrition.

title: The effects of pre- and postweaning dietary protein levels of mitochondrial metabolism in developing liver and interscapular brown adipose tissue (IBAT) in XXXX .

answer: @entity1


abstract: OBJECTIVES/HYPOTHESIS: First @entity3 is the sudden onset of acute and severe @entity1 in the parotid region at the initiation of mastication. Although it generally lasts less than a minute, it is disabling for these individuals and leads to a fear of oral intake. It is typically seen after parapharyngeal or deep parotid space surgery. Intraparotid injection of botulinum toxin A (BTA) has been suggested as a treatment for this condition, but there is little supporting literature to this effect. The purpose of this study is to document our experience using this treatment method for first @entity3 . STUDY DESIGN: Retrospective case review. METHODS: Five @entity0 with first @entity3 , developed after parapharyngeal space surgery, were treated by multisite injection of BTA into the parotid gland. Between 17.5 and 50 total U of BTA were injected into four or more sites in the parotid region. The @entity0 were then followed up every 4 months. RESULTS: Three of five @entity0 reported a significant improvement in symptoms at the 4-month follow-up visit, although complete resolution was not reported. One @entity0 reported only moderate improvement, and despite two series of injections there was no improvement in one @entity0 , leading us to question our initial diagnosis. CONCLUSIONS: Unilateral BTA injection into the affected parotid gland produces a decrease in the severity of symptoms. It is a safe and viable noninvasive treatment for this difficult to treat condition and may lead to permanent @entity2 in some @entity0 . LEVEL OF EVIDENCE: 4 Laryngoscope, 2015.

title: First XXXX : Our experience with intraparotid injections with botulinum toxin type A.

answer: @entity3


abstract: This study compares the role of M-mode and two-dimensional echocardiography in the evaluation of the nonstenotic, congenitally @entity4 . Ten asymptomatic healthy subjects (age 20-35 years) with a systolic ejection click and short systolic murmur were evaluated. M-mode echocardiograms were entirely normal. The aortic root, diastolic closure line, eccentricity index of the aortic valve, and left ventricular size and function were normal in every subject. The two-dimensional parasternal long @entity2 view of the aortic root was also normal in all @entity0 with bicuspid aortic valves; there were no abnormalities of systolic excursion of the aortic cusps and doming of the aortic valve was absent. Images obtained in the two-dimensional parasternal short @entity2 view of the aortic root at the level of the aortic valve revealed only two cusps, anterior and posterior, in all @entity0 . The classic closure pattern of the normal tricuspid aortic valve forming a "Y" was absent in every subject. Instead, a horizontal closure line along the "X" @entity2 was demonstrated in all @entity0 ; changing the angulation of the transducer in various positions did not alter this pattern. All subjects had increased reflectance of echoes along the line of diastolic closure, probably resulting from redundancy of the aortic cusp tissue. We conclude that because of the inability of the M-mode echocardiographic technique to accurately diagnose this condition in the study group, two-dimensional echocardiography should be the technique of choice in the evaluation of @entity0 with a suspected @entity4 . Recognition of this condition is important in view of its susceptibility to subacute @entity3 , @entity1 , and regurgitation.

title: Superiority of two-dimensional echocardiography in the diagnosis of congenitally XXXX .

answer: @entity4


abstract: BACKGROUND: @entity6 is a challenge for orthopaedic surgeons. There is a lack of scientific evidence to guide treatment. The purpose of this study was to report the clinical outcome of unplanned retention of antibiotic-impregnated cement spacer (ACS) in the management of @entity6 . METHODS: Eight @entity0 (7 with tibial infections and 1 with a @entity3 ) with @entity6 received radical debridement and insertion of an ACS into the bone defect as the definitive management. The mean follow-up period was 2  years (6  months to 4  years). All of these @entity0 had a cement spacer in place. RESULTS: No @entity0 exhibited radiographic evidence of excessive @entity4 . The @entity0 reported no or occasional mild @entity1 and exhibited complete weight-bearing abilities, with the exception of one @entity0 who required a crutch because of a @entity5 . Signs of recurrence of the @entity6 were not noted in any of the @entity0 , and no @entity2 occurred at last follow-up. CONCLUSION: Our study suggests that a proportion of @entity0 with unplanned retention of ACS appear to function well without necessarily requiring further surgical intervention.

title: Antibiotic-impregnated cement spacer as definitive management for XXXX .

answer: @entity6


abstract: Seven @entity0 subjected to @entity1 resection involving the acetabular ring were analyzed with respect to function. In addition to conventional clinical assessment gait was analyzed objectively by means of an electronic walk-way and residual hip-muscle power tested by means of a Cybex II dynamometer. Functional results reported by the @entity0 with respect to @entity2 , walking and working capacity appeared better than those elicited by clinical examination. All @entity0 exhibited a marked pelvic tilt and a positive Trendelenburg sign. Only one @entity0 walked without any kind of support. @entity3 was on an average 6 cm. Objective gait analysis disclosed that all @entity0 had reduced weight-bearing time on the operated side as compared to the non-operated. This, however, was clearly less pronounced for those @entity0 who appeared best with respect to @entity2 , walking and working capacity. These @entity0 also showed the best hip extension power which appeared more important from a functional point of view than hip flexion and, surprisingly, hip abduction power. Radiographic examination showed that bony support for the proximal femur, provided either by the formation of a bone shelf from the remaining iliac bone or by the remaining iliac bone itself, was of decisive importance for function. The results of the present study show that @entity1 resection involving the acetabular ring, provided @entity1 removal can be achieved, constitutes a feasible alternative to hemipelvectomy from a functional point of view.

title: Function after XXXX resection involving the acetabular ring.

answer: @entity1


abstract: We have encountered four cases of an unusual variant of well-differentiated @entity5 that was predominantly composed of tubules, solid or hollow, as well as cord-like areas histologically mimicking Sertoli and @entity6 . The two features most helpful in differential diagnosis were the presence of areas of @entity2 with the typical confluent pattern of @entity5 , and the presence of @entity4 at the apical borders of the @entity2 cells and/or within glandular lumina. Other features that were helpful if present, but were observed only in one case each, were foci of @entity3 or the presence of ciliated epithelium. In two cases, ultrastructural studies showed well developed microvilli and perinuclear microfilaments confirming the endometrioid nature of the @entity2 . The @entity0 varied from 22-74 years in age. All @entity2 were confined to a single ovary, and no @entity2 is known to have recurred or metastasized. One of the @entity0 died at age 80, six years following operation, presumably without evidence of recurrent @entity2 or @entity1 . Two other @entity0 are living and well, one and 14 years after diagnosis. In one @entity0 follow-up is short. The clinicopathologic features of this variant of @entity5 are reviewed with emphasis on differential morphologic features.

title: Ovarian endometrioid tumors mimicking Sertoli and XXXX : Sertoliform variant of @entity5 .

answer: @entity6


abstract: We have encountered four cases of an unusual variant of well-differentiated @entity5 that was predominantly composed of tubules, solid or hollow, as well as cord-like areas histologically mimicking Sertoli and @entity6 . The two features most helpful in differential diagnosis were the presence of areas of @entity2 with the typical confluent pattern of @entity5 , and the presence of @entity4 at the apical borders of the @entity2 cells and/or within glandular lumina. Other features that were helpful if present, but were observed only in one case each, were foci of @entity3 or the presence of ciliated epithelium. In two cases, ultrastructural studies showed well developed microvilli and perinuclear microfilaments confirming the endometrioid nature of the @entity2 . The @entity0 varied from 22-74 years in age. All @entity2 were confined to a single ovary, and no @entity2 is known to have recurred or metastasized. One of the @entity0 died at age 80, six years following operation, presumably without evidence of recurrent @entity2 or @entity1 . Two other @entity0 are living and well, one and 14 years after diagnosis. In one @entity0 follow-up is short. The clinicopathologic features of this variant of @entity5 are reviewed with emphasis on differential morphologic features.

title: Ovarian endometrioid tumors mimicking Sertoli and @entity6 : Sertoliform variant of XXXX .

answer: @entity5


abstract: Three cases of primary trabecular @entity3 are reported. In two cases the @entity2 was a pure @entity6 , while the third it was associated with @entity4 . The @entity0 were aged 36, 48 and 56 years. The presenting symptoms were lower @entity5 and the presence of a lower abdominal mass. In one case the @entity2 was found incidentally. There was no evidence of @entity1 or @entity6 in any of these cases. The treatment was bilateral salpingo-oophorectomy and hysterectomy in two cases and bilateral salpingo-oophorectomy in one case. All the @entity0 are well and disease-free for periods ranging from 4-13 years after surgery. The pathology, differential diagnosis and behavior of this entity are discussed and reviewed. Primary @entity6 of the ovary is an uncommon @entity3 , behaving like a @entity2 of low malignant potential. In the younger @entity0 the treatment is unilateral salpingo-oophorectomy, while in the postmenopausal @entity0 bilateral salpingo-oophorectomy and hysterectomy is the treatment of choice. Long-term follow-up is advisable.

title: Primary trabecular XXXX .

answer: @entity3


abstract: The occurrence of spontaneous @entity2 in Japanese newts (Cynops pyrrhogaster) from Niigata prefecture in Northern Japan was monitored over four seasons covering a period of 2 years. Of 13,613 newts, 249 were found to @entity4 . The percentage of newts with @entity4 was highest in autumn, ranging from 1.93 to 5.45% of the total average. These values were more than four times as high as values obtained in the other three seasons (0.16 to 0.50%). A total of 12,167 newts were collected from their natural environment in 10 prefectures of Japan in the autumn of 1980 and 1981. Newts collected from the northern, seaside prefectures had @entity4 rates (1.00 to 5.45%) than did newts from the Southern, Pacific Ocean prefectures of Japan (0 to 0.27%). Male and female newts were affected equally often by the @entity1 . @entity3 -like bodies, resembling @entity3 , were found in the cytoplasm of the @entity1 . These @entity3 -like bodies were not seen in the control epithelium of newts with normal skin and without @entity4 or in nonaffected regions of newts with @entity4 . It is suggested that @entity0 and @entity3 are causally related.

title: Seasonal and geographical changes of spontaneous XXXX in the Japanese newt Cynops pyrrhogaster.

answer: @entity2


abstract: The effect of circulatory arrest of the @entity1 and foot and head-up tilt upon pressure gradient over the thigh and distribution of muscle blood flow in the thigh was studied in 14 @entity0 with occlusion of the superficial femoral artery. In the supine position circulatory arrest just below the knee initially reduced the directly measured mean arterial pressure gradient over the thigh by about 30% indicating that a similar proportion of total leg blood flow supplied the @entity1 and foot. Local muscle blood flow was measured by the local 133Xe washout technique proximally and distally in the thigh muscle. Total leg blood flow was measured by an indicator dilution technique. During 10 min of circulatory arrest of the @entity1 and foot local muscle blood flow in the thigh increased by approximately 35% proximally and distally. Total leg blood flow remained unchanged and the pressure gradient was reduced by about 10% as compared with that before tourniquet. During head-up tilt local muscle blood flow in the thigh decreased by about 30% proximally and distally. Total leg blood flow also decreased by about 30%. Circulatory arrest below the knee did not alter this response. These findings indicate that blood flow change uniformly in the thigh during head-up tilt and during tourniquet on the @entity1 . Furthermore blood flow to the @entity1 appears only to account for 30% of the arterial pressure drop over the collateral arteries in the thigh, indicating that thigh blood flow is of major importance for the pressure gradient over the collateral arteries.

title: Influence of thigh blood flow upon the arterial pressure gradient over the collateral arteries in XXXX with occlusion of the superficial femoral artery.

answer: @entity0


abstract: Clinical evidence suggests some lack of cross resistance between @entity4 (VCR) and @entity9 (VDS). To investigate this phenomenon experimentally, drug-resistant L5178Y lymphoblast cell lines have been derived in vitro. These lines, under conditions of continuous drug exposure, exhibit a 50-fold order of resistance. Resistance appears due, at least in part, to impaired cellular drug accumulation and retention. Exposure of these resistant cells to VCR or VDS for 24 h showed that the presence or absence of cross resistance was dose-dependent, being most noticeable at low concentrations (less than 0.5 ng/ml) and absent at higher drug levels. Cross resistance also showed some dose-dependency for @entity8 and @entity10 , but this was not seen with other drugs. Marked and complete cross resistance at all concentrations tested was noted with @entity0 and @entity1 in both resistant lines, which, however, retained the same sensitivities as the parent line to @entity5 , @entity6 , @entity2 , and @entity3 . Responses to @entity7 and mAMSA differed in these two resistant lines. VDS-resistant cells exhibited cross resistance to both drugs, whilst VCR-resistant cells showed only slight resistance to @entity7 whilst retaining full sensitivity mAMSA. This observation that cross resistance between VCR and VDS is not invariable in vitro appears to reflect clinical experience.

title: Establishment of XXXX -resistant and @entity9 -resistant lines of murine lymphoblasts in vitro and characterisation of their patterns of cross-resistance and drug sensitivities.

answer: @entity4


abstract: Clinical evidence suggests some lack of cross resistance between @entity4 (VCR) and @entity9 (VDS). To investigate this phenomenon experimentally, drug-resistant L5178Y lymphoblast cell lines have been derived in vitro. These lines, under conditions of continuous drug exposure, exhibit a 50-fold order of resistance. Resistance appears due, at least in part, to impaired cellular drug accumulation and retention. Exposure of these resistant cells to VCR or VDS for 24 h showed that the presence or absence of cross resistance was dose-dependent, being most noticeable at low concentrations (less than 0.5 ng/ml) and absent at higher drug levels. Cross resistance also showed some dose-dependency for @entity8 and @entity10 , but this was not seen with other drugs. Marked and complete cross resistance at all concentrations tested was noted with @entity0 and @entity1 in both resistant lines, which, however, retained the same sensitivities as the parent line to @entity5 , @entity6 , @entity2 , and @entity3 . Responses to @entity7 and mAMSA differed in these two resistant lines. VDS-resistant cells exhibited cross resistance to both drugs, whilst VCR-resistant cells showed only slight resistance to @entity7 whilst retaining full sensitivity mAMSA. This observation that cross resistance between VCR and VDS is not invariable in vitro appears to reflect clinical experience.

title: Establishment of @entity4 -resistant and XXXX -resistant lines of murine lymphoblasts in vitro and characterisation of their patterns of cross-resistance and drug sensitivities.

answer: @entity9


abstract: BACKGROUND: @entity4 is a unique mesenchymal @entity1 composed of blood vessels as well as smooth muscle and adipose cells. The liver is a less common site of origin, and @entity2 is often an incidental finding on diagnostic imaging or is identified on evaluation of nonspecific symptoms. CASE PRESENTATION: We experienced four @entity0 who were diagnosed histologically with @entity2 . The preoperative diagnoses were @entity4 in two @entity0 , @entity3 in one, and @entity5 in one. Three @entity0 were treated with hepatectomy (one laparoscopic and two open approaches), and the diagnosis was completed by histological investigation of the resected specimen. The remaining one was diagnosed from @entity1 needle biopsy. Diffusion-weighted magnetic resonance imaging (MRI) with respiratory triggering using b values of 0 and 800  s/mm(2) was employed. An apparent diffusion coefficient map was generated from b values of 0 and 800  s/mm(2) for calculation of the apparent diffusion coefficient. The apparent diffusion coefficient values were calculated as 3.66, 1.21, 1.80, and 0.91 in @entity0 1 to 4, respectively. In MRI imaging, fat component was clearly demonstrated with chemical shift imaging in three @entity0 . Early venous return was detected in three @entity0 with computed tomography angiography. CONCLUSION: Fat component and early venous return are important for a correct diagnosis of @entity2 . Unfortunately, apparent diffusion coefficient values in @entity2 were overlapping with those in other benign and @entity1 .

title: XXXX with special attention to radiologic imaging.

answer: @entity2


abstract: INTRODUCTION: Single-site laparoscopic colectomy (SLC) is a promising minimally invasive and safe treatment for @entity2 . Improvements of the working instruments and procedures for SLC have helped to overcome challenges regarding the difficulty of operation, supporting the gradual acceptance of this technique. In contrast, narrow working space of the abdominal cavity sometimes prevents securing an adequate surgical view. To obtain precise anatomical information and enable complete mesocolic excision (CME), we routinely perform three-dimensional computed tomography prior to SLC. CASE PRESENTATION: A 69-year-old Japanese @entity0 was clinically diagnosed with @entity1 . Unexpectedly, preoperative examination revealed asymptomatic stenosis of the great artery, which was diagnosed as @entity4 . Because radical colectomy requires dissection of vessels that supply blood flow to the legs, a vascular stent was inserted prior to operation. We chose SLC due to the reduced risk of damaging epigastric arteries, which may eventually become collaterals in the event of stent re-stenosis. We accomplished SLC with CME, and the @entity0 was discharged on the tenth day after operation without complications. CONCLUSION: The present case is the first to proceed by SLC for @entity2 complicated by @entity3 . Preoperative imaging enabled us to identify an unexpected rare disease and to still accomplish SLC with CME, thus reinforcing the importance of preoperative imaging to optimize the use of SLC. In addition, SLC may become one of the most adequate procedures for @entity0 complicated by @entity3 .

title: Single-site laparoscopic colectomy for XXXX with @entity4 : report of a case.

answer: @entity1


abstract: INTRODUCTION: Single-site laparoscopic colectomy (SLC) is a promising minimally invasive and safe treatment for @entity2 . Improvements of the working instruments and procedures for SLC have helped to overcome challenges regarding the difficulty of operation, supporting the gradual acceptance of this technique. In contrast, narrow working space of the abdominal cavity sometimes prevents securing an adequate surgical view. To obtain precise anatomical information and enable complete mesocolic excision (CME), we routinely perform three-dimensional computed tomography prior to SLC. CASE PRESENTATION: A 69-year-old Japanese @entity0 was clinically diagnosed with @entity1 . Unexpectedly, preoperative examination revealed asymptomatic stenosis of the great artery, which was diagnosed as @entity4 . Because radical colectomy requires dissection of vessels that supply blood flow to the legs, a vascular stent was inserted prior to operation. We chose SLC due to the reduced risk of damaging epigastric arteries, which may eventually become collaterals in the event of stent re-stenosis. We accomplished SLC with CME, and the @entity0 was discharged on the tenth day after operation without complications. CONCLUSION: The present case is the first to proceed by SLC for @entity2 complicated by @entity3 . Preoperative imaging enabled us to identify an unexpected rare disease and to still accomplish SLC with CME, thus reinforcing the importance of preoperative imaging to optimize the use of SLC. In addition, SLC may become one of the most adequate procedures for @entity0 complicated by @entity3 .

title: Single-site laparoscopic colectomy for @entity1 with XXXX : report of a case.

answer: @entity4


abstract: Myocardial perfusion imaging with @entity7 has been found to be effective in the clinical evaluation of @entity0 with @entity3 . However, conventional myocardial perfusion imaging of the myocardium showing the postero-septal and antero-lateral wall cannot be obtained clearly by the conventional collimator due to the inevitable distance between the collimator and the heart. In contrast, 30, 60-degree @entity8 images were obtained clearly using slant-hole collimator with the collimator closely contact with the heart, which enables us to observe the postero-septal and antero-lateral walls of the myocardium. As a result, we obtained myocardial perfusion images every 30-degrees in a radial direction. By dividing @entity8 images into 12 segments, we compared perfusion defect in the myocardial scintigram with akinesis detected by echocardiography and contrast left ventriculography segmentally and referred to the character and accuracy of these three examinations. As a result, these three methods well agreed in cases with @entity3 of @entity1 , but did not always agree in cases with @entity1 . The character of each method was as follows: 1) Left ventriculography, which gives direct information concerning wall motion of the left ventricle, was most sensitive to detect @entity6 , but had a tendency to overestimate hypokinesis of wall motion due to its invasive nature. 2) In @entity2 , when hypoperfusion is associated with perfusion defect, we occasionally diagnose mistakenly the hypoperfusion area as normal because the scintigraphic evaluation is based on the relative distribution of perfusion. To avoid such underestimation, exercise @entity2 should be performed and @entity4 should be evaluated by comparing exercise images with redistribution images. Moreover, we studied extension of perfusion defect in the anterior and infero-posterior @entity5 groups. In anterior @entity3 , perfusion defect extended beyond the apex and reached the point one-third away from the apex to the base. In @entity3 , perfusion defect extended into the apex but did not exceed the apex. It seemed that the most suitable point to make the boundary between apical and infero-posterior areas was the point one-third away from the apex to the base along the inferior half of the @entity8 image of the myocardium.

title: [Evaluation of @entity4 by ( XXXX ) long-axial myocardial imaging using slant-hole collimator].

answer: @entity8


abstract: Myocardial perfusion imaging with @entity7 has been found to be effective in the clinical evaluation of @entity0 with @entity3 . However, conventional myocardial perfusion imaging of the myocardium showing the postero-septal and antero-lateral wall cannot be obtained clearly by the conventional collimator due to the inevitable distance between the collimator and the heart. In contrast, 30, 60-degree @entity8 images were obtained clearly using slant-hole collimator with the collimator closely contact with the heart, which enables us to observe the postero-septal and antero-lateral walls of the myocardium. As a result, we obtained myocardial perfusion images every 30-degrees in a radial direction. By dividing @entity8 images into 12 segments, we compared perfusion defect in the myocardial scintigram with akinesis detected by echocardiography and contrast left ventriculography segmentally and referred to the character and accuracy of these three examinations. As a result, these three methods well agreed in cases with @entity3 of @entity1 , but did not always agree in cases with @entity1 . The character of each method was as follows: 1) Left ventriculography, which gives direct information concerning wall motion of the left ventricle, was most sensitive to detect @entity6 , but had a tendency to overestimate hypokinesis of wall motion due to its invasive nature. 2) In @entity2 , when hypoperfusion is associated with perfusion defect, we occasionally diagnose mistakenly the hypoperfusion area as normal because the scintigraphic evaluation is based on the relative distribution of perfusion. To avoid such underestimation, exercise @entity2 should be performed and @entity4 should be evaluated by comparing exercise images with redistribution images. Moreover, we studied extension of perfusion defect in the anterior and infero-posterior @entity5 groups. In anterior @entity3 , perfusion defect extended beyond the apex and reached the point one-third away from the apex to the base. In @entity3 , perfusion defect extended into the apex but did not exceed the apex. It seemed that the most suitable point to make the boundary between apical and infero-posterior areas was the point one-third away from the apex to the base along the inferior half of the @entity8 image of the myocardium.

title: [Evaluation of XXXX by ( @entity8 ) long-axial myocardial imaging using slant-hole collimator].

answer: @entity4


abstract: Low density lipoprotein (LDL) and four subfractions, A, B, C, and D of very low density lipoprotein (VLDL), characterized by the following decreasing Sf values, greater than 400, 175-400, 100-175, and 20-100, respectively, were isolated by density gradient preparative ultracentrifugation from serum of normal @entity0 and @entity0 and analyzed for lipids, total protein, and @entity3 . The percentage distribution of the @entity4 of VLDL on fractions A to D were 1, 25, 30, and 45%, respectively, for both males and females. The numbers of VLDL particles for males in fractions B to D were 5, 10, and 40 X 10(12) per ml serum, respectively. Females, who had lower VLDL concentrations than males, had half as many particles per ml of serum. The number of LDL particles was similar in males and females and was 10 times that of VLDL. The relative composition of the lipoproteins changed progressively from fraction B to D and from D to LDL. The percentage of @entity2 and soluble proteins fell, due to loss of mass of these constituents from the particles. The percentage of @entity3 and @entity5 rose; this was not due to an increase of mass but because the particles became smaller. There were no sex differences. The numbers of molecules per particle of the constituents showed a successive decrease from VLDL-B to LDL for @entity4 , free @entity1 , phospholipids, and soluble apolipoproteins, while it remained constant for @entity3 , as well as for @entity5 from VLDL-C to LDL. These data fit the following hypothesis for the VLDL to LDL cascade. The large VLDL particle successively loses molecules of @entity4 (core) and of soluble protein, free @entity1 , and phospholipids (surface). In this process, VLDL retains its molecules of @entity3 , and @entity5 are lost from large VLDL but not from medium or small-sized VLDL.

title: Composition, concentration, and size of low density lipoproteins and of subfractions of very low density lipoproteins from serum of normal XXXX and @entity0 .

answer: @entity0


abstract: Low density lipoprotein (LDL) and four subfractions, A, B, C, and D of very low density lipoprotein (VLDL), characterized by the following decreasing Sf values, greater than 400, 175-400, 100-175, and 20-100, respectively, were isolated by density gradient preparative ultracentrifugation from serum of normal @entity0 and @entity0 and analyzed for lipids, total protein, and @entity3 . The percentage distribution of the @entity4 of VLDL on fractions A to D were 1, 25, 30, and 45%, respectively, for both males and females. The numbers of VLDL particles for males in fractions B to D were 5, 10, and 40 X 10(12) per ml serum, respectively. Females, who had lower VLDL concentrations than males, had half as many particles per ml of serum. The number of LDL particles was similar in males and females and was 10 times that of VLDL. The relative composition of the lipoproteins changed progressively from fraction B to D and from D to LDL. The percentage of @entity2 and soluble proteins fell, due to loss of mass of these constituents from the particles. The percentage of @entity3 and @entity5 rose; this was not due to an increase of mass but because the particles became smaller. There were no sex differences. The numbers of molecules per particle of the constituents showed a successive decrease from VLDL-B to LDL for @entity4 , free @entity1 , phospholipids, and soluble apolipoproteins, while it remained constant for @entity3 , as well as for @entity5 from VLDL-C to LDL. These data fit the following hypothesis for the VLDL to LDL cascade. The large VLDL particle successively loses molecules of @entity4 (core) and of soluble protein, free @entity1 , and phospholipids (surface). In this process, VLDL retains its molecules of @entity3 , and @entity5 are lost from large VLDL but not from medium or small-sized VLDL.

title: Composition, concentration, and size of low density lipoproteins and of subfractions of very low density lipoproteins from serum of normal @entity0 and XXXX .

answer: @entity0


abstract: UNASSIGNED: Background: This is a case report of sensory assessment in a @entity0 with severe chronic @entity6 following uterine artery embolization, and a discussion of a commonly observed sensory manifestation ( @entity5 ) associated with chronic @entity6 due to gynaecological conditions. Allodynia, as a common sensory abnormality can be readily detected at the bedside and represents the development of @entity1 sensitization. Emergence of abdominal and perineal @entity5 (assessed by @entity7 swap stroking and/or questionnaire) is associated with the development of the clinical features of sensitization: continuous @entity6 , @entity4 , and reduced pressure @entity1 thresholds. Case: A uterine artery embolization was performed on a 42-year-old @entity0 to treat a postpartum @entity3 . The @entity0 experienced severe @entity1 immediately following the procedure, and it had persisted for one year when she was referred for chronic unrelenting @entity1 . She was found to have extensive @entity5 , @entity2 , and reduced @entity1 thresholds. A hysterectomy was undertaken. As the @entity1 persisted, botulinum toxin was administered to the lower abdomen in the region of reduced @entity1 thresholds. Partial resolution of @entity1 , physical limitation, and @entity5 resolved one year after the hysterectomy and shortly after the injections of four tender regions of the anterior cutaneous nerves with 2.5 and 5.0 IU of botulinum toxin. Conclusion: Testing for @entity5 is a validated bedside test for @entity1 sensitization. A clinical trial of botulinum toxin is indicated for the management of chronic @entity6 associated with @entity5 and @entity1 sensitization.

title: The Significance of XXXX in a @entity0 With Chronic Pelvic Pain.

answer: @entity5


abstract: UNASSIGNED: Background: This is a case report of sensory assessment in a @entity0 with severe chronic @entity6 following uterine artery embolization, and a discussion of a commonly observed sensory manifestation ( @entity5 ) associated with chronic @entity6 due to gynaecological conditions. Allodynia, as a common sensory abnormality can be readily detected at the bedside and represents the development of @entity1 sensitization. Emergence of abdominal and perineal @entity5 (assessed by @entity7 swap stroking and/or questionnaire) is associated with the development of the clinical features of sensitization: continuous @entity6 , @entity4 , and reduced pressure @entity1 thresholds. Case: A uterine artery embolization was performed on a 42-year-old @entity0 to treat a postpartum @entity3 . The @entity0 experienced severe @entity1 immediately following the procedure, and it had persisted for one year when she was referred for chronic unrelenting @entity1 . She was found to have extensive @entity5 , @entity2 , and reduced @entity1 thresholds. A hysterectomy was undertaken. As the @entity1 persisted, botulinum toxin was administered to the lower abdomen in the region of reduced @entity1 thresholds. Partial resolution of @entity1 , physical limitation, and @entity5 resolved one year after the hysterectomy and shortly after the injections of four tender regions of the anterior cutaneous nerves with 2.5 and 5.0 IU of botulinum toxin. Conclusion: Testing for @entity5 is a validated bedside test for @entity1 sensitization. A clinical trial of botulinum toxin is indicated for the management of chronic @entity6 associated with @entity5 and @entity1 sensitization.

title: The Significance of @entity5 in a XXXX With Chronic Pelvic Pain.

answer: @entity0


abstract: UNASSIGNED: Spectro-Temporal Receptive Fields (STRFs) were estimated from both multi-unit sorted clusters and high-gamma power responses in @entity0 auditory cortex. Intracranial electrophysiological recordings were used to measure responses to a random chord sequence of Gammatone stimuli. Traditional methods for estimating STRFs from single-unit recordings, such as spike-triggered-averages, tend to be noisy and are less robust to other response signals such as local field potentials. We present an extension to recently advanced methods for estimating STRFs from @entity1 ( @entity1 ). A new variant of regression using regularization that penalizes non-zero coefficients is described, which results in a sparse solution. The frequency-time structure of the STRF tends toward grouping in different areas of frequency-time and we demonstrate that group sparsity-inducing penalties applied to @entity1 estimates of STRFs reduces the background noise while preserving the complex internal structure. The contribution of local spiking activity to the high-gamma power signal was factored out of the STRF using the @entity1 method, and this contribution was significant in 85 percent of the cases. Although the @entity1 methods have been used to estimate STRFs in animals, this study examines the detailed structure directly from auditory cortex in the awake @entity0 brain. We used this approach to identify an abrupt change in the best frequency of estimated STRFs along posteromedial-to-anterolateral recording locations along the long axis of Heschl's gyrus. This change correlates well with a proposed transition from core to non-core auditory fields previously identified using the temporal response properties of Heschl's gyrus recordings elicited by click-train stimuli.

title: Sparse Spectro-Temporal Receptive Fields Based on Multi-Unit and High-Gamma Responses in XXXX Auditory Cortex.

answer: @entity0


abstract: The antinociceptive (radiant heat tail-flick), convulsant and lethal activities of @entity7 ( @entity8 ) and @entity9 (NMEP) were studied after s.c. and i.c.v. administration to @entity0 . Both compounds s.c. exhibited @entity4 -reversible antinociceptive activity. MEP (ED50 = 23 mg/kg) was 2.5 to 5 times more potent, on a molar basis, than NMEP (ED50 = 72 mg/kg). NMEP was a convulsant [ED50 = 105 mg/kg (s.c.) and 64 micrograms/ @entity0 (i.c.v.)], with a small therapeutic index relative to @entity3 whose activity was potentiated by @entity4 and antagonized by @entity6 or @entity2 , s.c. Death due to s.c. MEP was preceded by @entity1 , whereas i.c.v. MEP provoked a primarily depressant lethality. @entity4 antagonized death due to i.c.v. MEP while unmasking its convulsant activity. It is concluded that NMEP is the principal mediator of MEPs central nervous system excitation, that @entity1 are mediated by a different population of receptors than either @entity5 and that @entity4 exacerbates the convulsant activity of MEP and NMEP.

title: Antinociceptive activity and toxicity of XXXX and @entity9 in @entity0 .

answer: @entity7


abstract: The antinociceptive (radiant heat tail-flick), convulsant and lethal activities of @entity7 ( @entity8 ) and @entity9 (NMEP) were studied after s.c. and i.c.v. administration to @entity0 . Both compounds s.c. exhibited @entity4 -reversible antinociceptive activity. MEP (ED50 = 23 mg/kg) was 2.5 to 5 times more potent, on a molar basis, than NMEP (ED50 = 72 mg/kg). NMEP was a convulsant [ED50 = 105 mg/kg (s.c.) and 64 micrograms/ @entity0 (i.c.v.)], with a small therapeutic index relative to @entity3 whose activity was potentiated by @entity4 and antagonized by @entity6 or @entity2 , s.c. Death due to s.c. MEP was preceded by @entity1 , whereas i.c.v. MEP provoked a primarily depressant lethality. @entity4 antagonized death due to i.c.v. MEP while unmasking its convulsant activity. It is concluded that NMEP is the principal mediator of MEPs central nervous system excitation, that @entity1 are mediated by a different population of receptors than either @entity5 and that @entity4 exacerbates the convulsant activity of MEP and NMEP.

title: Antinociceptive activity and toxicity of @entity7 and XXXX in @entity0 .

answer: @entity9


abstract: The antinociceptive (radiant heat tail-flick), convulsant and lethal activities of @entity7 ( @entity8 ) and @entity9 (NMEP) were studied after s.c. and i.c.v. administration to @entity0 . Both compounds s.c. exhibited @entity4 -reversible antinociceptive activity. MEP (ED50 = 23 mg/kg) was 2.5 to 5 times more potent, on a molar basis, than NMEP (ED50 = 72 mg/kg). NMEP was a convulsant [ED50 = 105 mg/kg (s.c.) and 64 micrograms/ @entity0 (i.c.v.)], with a small therapeutic index relative to @entity3 whose activity was potentiated by @entity4 and antagonized by @entity6 or @entity2 , s.c. Death due to s.c. MEP was preceded by @entity1 , whereas i.c.v. MEP provoked a primarily depressant lethality. @entity4 antagonized death due to i.c.v. MEP while unmasking its convulsant activity. It is concluded that NMEP is the principal mediator of MEPs central nervous system excitation, that @entity1 are mediated by a different population of receptors than either @entity5 and that @entity4 exacerbates the convulsant activity of MEP and NMEP.

title: Antinociceptive activity and toxicity of @entity7 and @entity9 in XXXX .

answer: @entity0


abstract: 1. Effects of hypertonic solutions prepared by adding @entity3 or @entity2 to Krebs solution on intracellular potentials were observed in neurones of the supraoptic nucleus using brain slices of the @entity1 hypothalamus. 2. @entity4 solutions (306-488 m-osmole/kg) depolarized the membrane, increased the input resistance and augmented the spontaneous firing rate in supraoptic neurones, whereas cells in the hippocampus and anterior or ventromedial hypothalamus were not affected by the hypertonic solutions. 3. The excitatory action of hypertonic solutions on supraoptic neurones was retained in the medium containing 0 mM- @entity0 and 12 mM-Mg2+. 4. Amplitude of the depolarization induced by superfusion of hypertonic solutions was voltage-dependent. The reversal potential for the depolarization was about -90 mV. 5. The reversal potential for the depolarization induced by hypertonic solution shifted as a function of [K+]0. 6. These results suggest that the supraoptic neurones are themselves osmosensitive and that the local osmotic-related information is transduced to neural signals in these cells by alteration in the membrane ionic permeability, probably due to suppression of K+ conductance.

title: Ionic mechanism for the osmotically-induced depolarization in neurones of the XXXX supraoptic nucleus in vitro.

answer: @entity1


abstract: The aim of this study was to test the hypothesis that our 60-gene DNA/RNA ThyroSeq v2 next-generation sequence (NGS) assay would identify additional genetic markers, including gene fusions in sporadic pediatric differentiated @entity2 (DTC) that had no known molecular alterations. Sporadic pediatric DTCs with informative molecular testing (n = 18) were studied. We previously tested 15 cases by our standard 7-gene ( @entity3 , @entity8 , @entity9 , @entity4 , @entity11 / @entity6 , @entity11 / @entity16 , @entity15 / @entity7 ) mutation panel. Three cases were not tested previously. The standard 7-gene panel identified molecular alterations in 9 of 15 @entity0 (60%). Cases analyzed by ThyroSeq v2 NGS included the six previously negative cases by the standard 7-gene panel and three cases not previously tested. The NGS assay revealed new gene fusions in four of six previously negative cases (67%). These gene fusions included @entity12 / @entity14 (n = 3) and @entity13 / @entity5 (n = 1). A point mutation ( @entity3 - @entity10 ) was detected in one of three untested cases. While standard testing could identify only molecular alterations in 60% of cases, with the addition of the ThyroSeq v2 NGS, this increased to 87% (n = 13/15). Some cases with chromosomal rearrangements, including @entity12 / @entity14 , appear to be associated with an @entity1 histopathologic phenotype, but had no documented history of radiation exposure. Additional work is needed to investigate if pediatric DTCs could benefit from a reclassification based on molecular subtypes, which may better reflect their underlying biologic potential. Our data support the use of broad gene panels for the molecular diagnostics of pediatric thyroid nodules to aid future classification, treatment, and clinical management recommendations.

title: Molecular Characterization of Sporadic Pediatric XXXX with the DNA/RNA ThyroSeq v2 Next-Generation Sequencing Assay.

answer: @entity2


abstract: BACKGROUNDS: Radioactive tracer-based detection has been proposed as a standard procedure in identifying sentinel nodes for cN0 @entity2 . However, access to radioactive isotopes may be limited in some surgical centers, and there is potential risk of the radioactive tracers to the operators. This study was designed to evaluate the feasibility of near-infrared fluorescence imaging with @entity3 combined with blue dye mapping in sentinel node biopsy for cN0 @entity2 . METHODS: Twenty-six cases of previously untreated @entity2 staged cT1-2N0M0 were enrolled in this study. One milliliter of @entity3 (5 mg/ml) and 1.5 ml of @entity4 (1 mg/ml) were injected sequentially around the primary @entity1 in a four-quadrant pattern before skin incision. After elevation of the platysma flap and posterior retraction of the sternocleidomastoid muscle, fluorescence images were taken with a near-infrared detector, with special attention paid to any blue-dyed lymph nodes. Lymph nodes identified first with fluorescent hot spots with or without blue dye were defined as sentinel nodes, and they were harvested and sent for pathologic study. RESULTS: Sentinel nodes were successfully harvested in all 26 cases. The number of sentinel nodes (SNs) per case varied from 1 to 9, with an average of 3.4. Routine pathology demonstrated occult @entity0 exclusively in SNs in four cases (15.4 %). No tracer-associated side effects occurred in this series. CONCLUSIONS: Near-infrared imaging using @entity3 combined with @entity4 mapping is a feasible and reliable new method for SN biopsy in cN0 @entity2 .

title: Sentinel node biopsy using XXXX in @entity1 .

answer: @entity3


abstract: BACKGROUNDS: Radioactive tracer-based detection has been proposed as a standard procedure in identifying sentinel nodes for cN0 @entity2 . However, access to radioactive isotopes may be limited in some surgical centers, and there is potential risk of the radioactive tracers to the operators. This study was designed to evaluate the feasibility of near-infrared fluorescence imaging with @entity3 combined with blue dye mapping in sentinel node biopsy for cN0 @entity2 . METHODS: Twenty-six cases of previously untreated @entity2 staged cT1-2N0M0 were enrolled in this study. One milliliter of @entity3 (5 mg/ml) and 1.5 ml of @entity4 (1 mg/ml) were injected sequentially around the primary @entity1 in a four-quadrant pattern before skin incision. After elevation of the platysma flap and posterior retraction of the sternocleidomastoid muscle, fluorescence images were taken with a near-infrared detector, with special attention paid to any blue-dyed lymph nodes. Lymph nodes identified first with fluorescent hot spots with or without blue dye were defined as sentinel nodes, and they were harvested and sent for pathologic study. RESULTS: Sentinel nodes were successfully harvested in all 26 cases. The number of sentinel nodes (SNs) per case varied from 1 to 9, with an average of 3.4. Routine pathology demonstrated occult @entity0 exclusively in SNs in four cases (15.4 %). No tracer-associated side effects occurred in this series. CONCLUSIONS: Near-infrared imaging using @entity3 combined with @entity4 mapping is a feasible and reliable new method for SN biopsy in cN0 @entity2 .

title: Sentinel node biopsy using @entity3 in XXXX .

answer: @entity1