abstract: BACKGROUND: 13-18% of all preschool @entity0 have severe @entity1 at least transiently, sometimes with long-term adverse consequences. In this study, the social training program "Lubo aus dem All! - Vorschulalter" (Lubo from Outer Space, Preschool Version) was evaluated in a kindergarten setting. METHODS: 15 kindergartens were randomly assigned to either an intervention group or a control group, in a 2:1 ratio. The intervention was designed to strengthen emotional knowledge and regulation, the ability to take another @entity0 's point of view, communication skills, and social problem solving. The control group continued with conventional kindergarten activities. The primary endpoint was improvement in social-cognitive problem solving strategies, as assessed with the Wally Social Skills and Problem Solving Game (Wally). Secondary endpoints were improvement in prosocial behavior and reduction in problematic behavior, as assessed with the Preschool Social Behavior Questionnaire (PSBQ) and the Caregiver-Teacher Report Form (C-TRF). Data were collected before and after the intervention and also 5 months later. Mixed models were calculated with random effects to take account of the cluster design and for adjustment for confounding variables. RESULTS: 221 @entity0 in kindergarten, aged 5-6 years, were included in the study. Randomization was unsuccessful: the @entity0 in the intervention group performed markedly worse on the tests carried out before the intervention. Five months after the end of the intervention, the social-cognitive problem solving strategies of the @entity0 in the intervention group had improved more than those of the @entity0 in the control group: the intergroup difference in improvement was 0.79 standard deviations of the Wally test (95% confidence interval [CI] 0.13-1.46). This effect was just as marked 5 months later (0.63, 95% CI 0.03-1.23). Prosocial behavior, as measured by the PSBQ, also improved more in the intervention group, with an intergroup difference of 0.37 standard deviations (95% CI 0.05-0.71). CONCLUSION: An age-appropriate program to prevent @entity1 among kindergarten @entity0 improved both the @entity0 's knowledge of prosocial problem solving strategies and their prosocial behavior.

title: Preventing XXXX via Supporting Social and Emotional Competence at Preschool Age.

answer: @entity1


abstract: Studies were performed on a cytotoxin (CT) from @entity0 strains of @entity6 isolated in Malaysia. CT was detected by cytopathic effect (CPE) on HeLa cells at titres from 8 to 32, in culture filtrates from 14 (48%) of 29 @entity0 isolates. The CPE correlated well with a quantitative 51Cr-release assay where a specific release of 54-68% was noted. CT production was lost after 5-7 subcultures. CT activity was also detected in 5 (26%) of 19 faecal filtrates from which CT-producing isolates were subsequently obtained. The mol. wt of CT was estimated by Sephadex G-50 chromatography to be greater than 30,000. In a suckling- @entity1 assay, CT consistently failed to demonstrate fluid accumulation after intragastric inoculation of culture filtrate. The Removable Intestinal Tie Adult @entity2 @entity4 (RITARD) assay was also used. @entity2 given CT-producing strains of @entity6 developed @entity5 and severe watery mucus-containing @entity4 for the duration of the experiment with @entity3 of some animals. @entity2 given CT non-producing strains had less severe disease and none died. @entity2 given partially-purified CT had @entity4 for 3 days but none died.

title: In-vitro and in-vivo studies of a cytotoxin from XXXX .

answer: @entity6


abstract: UNASSIGNED: @entity6 is recognized as the main enzyme involved in the metabolism of drugs and xenobiotics in the @entity0 body and its inhibition may lead to undesirable consequences. @entity7 , including @entity4 , belong to a group of dietary health-promoting compounds that also act as inhibitors of @entity6 . The aim of this study was to examine the use of computer modeling of enzyme-ligand interactions to analyze and predict the inhibition of structurally related compounds. To this end, an @entity5 group was attached to @entity4 and the interactions of @entity6 with @entity4 , its @entity5 analogue (RA) and a known synthetic inhibitor were studied and compared in two biological models. Specifically, the metabolism of @entity2 was examined in a @entity0 intestine cell line (Caco-2/TC7) and in @entity1 liver microsomes (RLM). The results demonstrated a weak inhibitory effect of RA on @entity6 , as compared to @entity4 itself, in both biological models. @entity0 @entity6 was more susceptible to inhibition than the commonly used model isozyme from @entity1 . Modeling of the binding site of @entity6 revealed a combination of three types of interactions: hydrophobic interactions, electrostatic interactions and @entity3 bonds. A docking simulation revealed that the RA lacked an important binding feature, as compared to @entity4 , and that that difference may be responsible for its lower level of affinity for @entity6 . Software analysis of binding affinity may serve as a predictive tool for designing new therapeutic compounds in terms of inhibition of @entity6 and help to reveal the biochemical nature of the interactions of dietary compounds, herbal compounds and drugs whose metabolism is mediated by this enzyme.

title: Use of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by XXXX .

answer: @entity7


abstract: INTRODUCTION: @entity8 ( @entity8 ) is a condition that results from restricted blood flow to the posterior portions of the brain, which are primarily served by the vertebral and basilar arteries. It is the most common cause of @entity9 in the elderly and is usually accompanied by @entity4 . @entity3 , @entity5 , @entity1 and/or @entity2 may all lead to decreased vertebrobasilar circulation. A syndrome called @entity7 ( @entity7 ), which manifests with similar neurological symptoms but with a different pathophysiology, may also cause @entity8 . CASE PRESENTATION: A middle-aged female presented with gradual onset fainting and @entity9 attacks. Cardiac, auditory and autonomic etiologies were investigated and excluded. Clinical findings and presentation were highly suggestive of subclavian steal. However, subsequent CT angiography showed normal subclavian arteries. Instead, findings included a persistent right trigeminal artery (PTA), @entity6 of the right proximal internal carotid artery, atresis of the left vertebral artery and distal segment of right vertebral artery, congenitally compromised changes in vertebral circulation (bilateral absence of the posterior communicating arteries (PCOMs)) and an absent anterograde vertebrobasilar circulation. Symptoms resolved after carotid endarterectomy. DISCUSSION: Due to the absence of a normally developed posterior circulation, the PTA was the main source of blood supply for the @entity0 . Development of recent artheromatous changes in the right internal carotid artery, however, resulted in decreased blood through PTA, further compromising posterior circulation. This resulted in @entity8 , and manifested in symptomology similar to @entity7 . CONCLUSIONS: This clinical encounter illustrates the relative contribution of anatomical and vasoocclusive factors in closely mimicking symptoms of @entity7 .

title: Pseudo XXXX : Case report.

answer: @entity7


abstract: BACKGROUND: Structural hemoglobinopathies do not usually have a clinical impact, but they can interfere with the analytical determination of some parameters, such as the glycated hemoglobin in diabetic @entity0 . Thalassemias represent a serious health problem in areas where their incidence is high. The defects in the post-translational modifications produce hyper-unstable hemoglobin that is not detected by most of electrophoretic or chromatographic methods that are available so far. METHODS: We studied seven @entity0 who belong to six unrelated families. The first two families were studied because they had peak abnormal hemoglobin (Hb) during routine analytical assays. The other four families were studied because they had microcytosis and hypochromia with normal @entity2 and HbF without @entity1 deficiency. @entity2 and F quantification and abnormal Hb separation were performed by chromatographic and electrophoretic methods. The molecular characterization was performed using specific sequencing. RESULTS: The Hb Puerta del Sol presents electrophoretic mobility and elution in HPLC that is different from HbA and similar to HbS. The electrophoretic and chromatographic profiles of the four other variants are normal and do not show any anomalies, and their identification was only possible with sequencing. Conlcusions: Some variants, such as Hb Valdecilla, Hb Gran V  a, Hb Macarena and Hb El Retiro, have significant clinical impact when they are associated with other forms of a-thalassemia, which could lead to more serious forms of this group of pathologies as for HbH disease. Therefore, it is important to maintain an adequate program for screening these diseases in countries where the prevalence is high to prevent the occurrence of severe forms.

title: HB Puerta del Sol [HBA1:c.148A>C], HB Valdecilla [ @entity2 :c.3G>T], HB Gran V  a [ @entity2 :c.98T>G], HB Macarena [ @entity2 :c.358C>T], and HB El Retiro [ XXXX :c.364_366dupGTG]: description of five new hemoglobinopathies.

answer: @entity2


abstract: BACKGROUND: Structural hemoglobinopathies do not usually have a clinical impact, but they can interfere with the analytical determination of some parameters, such as the glycated hemoglobin in diabetic @entity0 . Thalassemias represent a serious health problem in areas where their incidence is high. The defects in the post-translational modifications produce hyper-unstable hemoglobin that is not detected by most of electrophoretic or chromatographic methods that are available so far. METHODS: We studied seven @entity0 who belong to six unrelated families. The first two families were studied because they had peak abnormal hemoglobin (Hb) during routine analytical assays. The other four families were studied because they had microcytosis and hypochromia with normal @entity2 and HbF without @entity1 deficiency. @entity2 and F quantification and abnormal Hb separation were performed by chromatographic and electrophoretic methods. The molecular characterization was performed using specific sequencing. RESULTS: The Hb Puerta del Sol presents electrophoretic mobility and elution in HPLC that is different from HbA and similar to HbS. The electrophoretic and chromatographic profiles of the four other variants are normal and do not show any anomalies, and their identification was only possible with sequencing. Conlcusions: Some variants, such as Hb Valdecilla, Hb Gran V  a, Hb Macarena and Hb El Retiro, have significant clinical impact when they are associated with other forms of a-thalassemia, which could lead to more serious forms of this group of pathologies as for HbH disease. Therefore, it is important to maintain an adequate program for screening these diseases in countries where the prevalence is high to prevent the occurrence of severe forms.

title: HB Puerta del Sol [HBA1:c.148A>C], HB Valdecilla [ @entity2 :c.3G>T], HB Gran V  a [ @entity2 :c.98T>G], HB Macarena [ XXXX :c.358C>T], and HB El Retiro [ @entity2 :c.364_366dupGTG]: description of five new hemoglobinopathies.

answer: @entity2


abstract: BACKGROUND: Structural hemoglobinopathies do not usually have a clinical impact, but they can interfere with the analytical determination of some parameters, such as the glycated hemoglobin in diabetic @entity0 . Thalassemias represent a serious health problem in areas where their incidence is high. The defects in the post-translational modifications produce hyper-unstable hemoglobin that is not detected by most of electrophoretic or chromatographic methods that are available so far. METHODS: We studied seven @entity0 who belong to six unrelated families. The first two families were studied because they had peak abnormal hemoglobin (Hb) during routine analytical assays. The other four families were studied because they had microcytosis and hypochromia with normal @entity2 and HbF without @entity1 deficiency. @entity2 and F quantification and abnormal Hb separation were performed by chromatographic and electrophoretic methods. The molecular characterization was performed using specific sequencing. RESULTS: The Hb Puerta del Sol presents electrophoretic mobility and elution in HPLC that is different from HbA and similar to HbS. The electrophoretic and chromatographic profiles of the four other variants are normal and do not show any anomalies, and their identification was only possible with sequencing. Conlcusions: Some variants, such as Hb Valdecilla, Hb Gran V  a, Hb Macarena and Hb El Retiro, have significant clinical impact when they are associated with other forms of a-thalassemia, which could lead to more serious forms of this group of pathologies as for HbH disease. Therefore, it is important to maintain an adequate program for screening these diseases in countries where the prevalence is high to prevent the occurrence of severe forms.

title: HB Puerta del Sol [HBA1:c.148A>C], HB Valdecilla [ @entity2 :c.3G>T], HB Gran V  a [ XXXX :c.98T>G], HB Macarena [ @entity2 :c.358C>T], and HB El Retiro [ @entity2 :c.364_366dupGTG]: description of five new hemoglobinopathies.

answer: @entity2


abstract: BACKGROUND: Structural hemoglobinopathies do not usually have a clinical impact, but they can interfere with the analytical determination of some parameters, such as the glycated hemoglobin in diabetic @entity0 . Thalassemias represent a serious health problem in areas where their incidence is high. The defects in the post-translational modifications produce hyper-unstable hemoglobin that is not detected by most of electrophoretic or chromatographic methods that are available so far. METHODS: We studied seven @entity0 who belong to six unrelated families. The first two families were studied because they had peak abnormal hemoglobin (Hb) during routine analytical assays. The other four families were studied because they had microcytosis and hypochromia with normal @entity2 and HbF without @entity1 deficiency. @entity2 and F quantification and abnormal Hb separation were performed by chromatographic and electrophoretic methods. The molecular characterization was performed using specific sequencing. RESULTS: The Hb Puerta del Sol presents electrophoretic mobility and elution in HPLC that is different from HbA and similar to HbS. The electrophoretic and chromatographic profiles of the four other variants are normal and do not show any anomalies, and their identification was only possible with sequencing. Conlcusions: Some variants, such as Hb Valdecilla, Hb Gran V  a, Hb Macarena and Hb El Retiro, have significant clinical impact when they are associated with other forms of a-thalassemia, which could lead to more serious forms of this group of pathologies as for HbH disease. Therefore, it is important to maintain an adequate program for screening these diseases in countries where the prevalence is high to prevent the occurrence of severe forms.

title: HB Puerta del Sol [HBA1:c.148A>C], HB Valdecilla [ XXXX :c.3G>T], HB Gran V  a [ @entity2 :c.98T>G], HB Macarena [ @entity2 :c.358C>T], and HB El Retiro [ @entity2 :c.364_366dupGTG]: description of five new hemoglobinopathies.

answer: @entity2


abstract: The evaluation of victims of @entity2 has evolved over the last few years, primarily as a result of the introduction of innovative, sensitive, and informative diagnostic procedures. The role of the neurologist appears to have been redefined as one in which the identification of the presumptive cause and mechanism of the @entity1 is one of the primary responsibilities. We compared the etiologic @entity1 subtypes of @entity0 entered into the Saint Louis University Stroke Registry for the period January to June, 1986 (Group A), with analogous data collected in @entity0 entered from January to June, 1992 (Group B). Group A included 57 @entity0 whose @entity1 subtype distribution was as follows: 19% due to athero- @entity4 , 18% cardiogenic, 5% lacunar, and 4% due to other causes. In addition, 54% of @entity0 had @entity1 of unknown etiology. Group B comprised 137 @entity0 with the following etiologic distribution: 35% cardiogenic, 26% atherothrombolic, 3% lacunar, and 6% from other causes. Only 29% had @entity1 of unknown etiology. The apparent increase in the proportion of @entity1 may be related to wider utilization of transesophageal echocardiography. There was also a significant drop in the proportion of @entity1 of unknown etiology. Finally, in comparison with other @entity1 registries, our data suggest that many small @entity1 may also result from @entity3 . These apparent changes in the proportion of @entity1 subtypes should be considered when @entity0 are being evaluated for risk stratification.

title: Changing trends in the etiologic diagnosis of XXXX .

answer: @entity2


abstract: Carotid artery surgical specimens from 15 consecutive @entity0 undergoing carotid endarterectomy were studied in an attempt to identify morphologic differences between carotid @entity5 (NV) and normal vasa vasorum (VV). The @entity0 included 12 @entity0 and 3 @entity0 with an age range of 55-81 years (mean, 67). Nine of them had @entity1 symptoms directly related to the plaque being removed. The specimens were stained with @entity6 - @entity7 , Verhoef-Van Gieson, and factor VIII-related antigen techniques. In addition, normal carotid arteries were obtained for comparison from two autopsies of young individuals, victims of @entity4 . The severity of NV within the plaque was graded based on the appearance and location of new vessels, as they compared to W. Mild NV (Grade I) was found in 3/15, whereas moderate and severe (Grades II and III) were each found in 6/15 cases. Increasing severity of NV was associated with more tortuosity, thicker walls, and location closer to the carotid lumen. The presence and severity of NV did not correlate with @entity3 (p = 0.2), the presence of symptoms (p = 0.5), or any other risk factors for @entity2 . Carotid plaque NV seems independent of the degree of @entity8 and morphologically different than VV. Its origin, true incidence, and role in the production of carotid intraplaque hemorrhage and @entity2 risk are still uncertain. This is the first immunohistochemical study of @entity5 .

title: Immunohistochemistry of XXXX and vasa vasorum.

answer: @entity5


abstract: INTRODUCTION: Diagnosis of @entity5 ( @entity5 ) is difficult because all clinical and biological signs are rarely concordant. According to recent literature, @entity6 could act as a specific marker of @entity3 . Our main objective was to assess whether @entity6 could improve our management of @entity0 with preterm premature @entity2 (pPROM), allowing earlier and more specific diagnosis for @entity5 . METHODS: @entity0 with pPROM from 24  and 34weeks of @entity4 were included, from November 2013  to October 2014. @entity6 was collected twice a week, from pPROM until delivery. Obstetricians were blinded from @entity6 results, in order not to influence the management of the @entity0 . @entity6 values were then compared to clinical and other biological diagnostic markers (CRP and white blood cells count [WBC]). RESULTS: Thirty @entity0 were included, with 11  cases of histological @entity5 and 5  early-onset @entity1 . With a cut-off value of 0.05ng/mL, the sensitivity of @entity6 to detect histological @entity5 was 54%, the specificity was 79% and the positive and negative predictive value were respectively 60% and 75%. The positive likelihood ratio was 2.57  and the negative likelihood ratio was 0.58. Using @entity6 values, our medical decision of foetal extraction would have change in 5  cases (in a wrong way in 3  of them). CONCLUSION: @entity6 in the diagnostic of @entity5 is not useful in the management of @entity0 .

title: [Evaluation of the interest of procalcitonin in the diagnosis of @entity5 in preterm premature XXXX . An observational and prospective study].

answer: @entity2


abstract: INTRODUCTION: Diagnosis of @entity5 ( @entity5 ) is difficult because all clinical and biological signs are rarely concordant. According to recent literature, @entity6 could act as a specific marker of @entity3 . Our main objective was to assess whether @entity6 could improve our management of @entity0 with preterm premature @entity2 (pPROM), allowing earlier and more specific diagnosis for @entity5 . METHODS: @entity0 with pPROM from 24  and 34weeks of @entity4 were included, from November 2013  to October 2014. @entity6 was collected twice a week, from pPROM until delivery. Obstetricians were blinded from @entity6 results, in order not to influence the management of the @entity0 . @entity6 values were then compared to clinical and other biological diagnostic markers (CRP and white blood cells count [WBC]). RESULTS: Thirty @entity0 were included, with 11  cases of histological @entity5 and 5  early-onset @entity1 . With a cut-off value of 0.05ng/mL, the sensitivity of @entity6 to detect histological @entity5 was 54%, the specificity was 79% and the positive and negative predictive value were respectively 60% and 75%. The positive likelihood ratio was 2.57  and the negative likelihood ratio was 0.58. Using @entity6 values, our medical decision of foetal extraction would have change in 5  cases (in a wrong way in 3  of them). CONCLUSION: @entity6 in the diagnostic of @entity5 is not useful in the management of @entity0 .

title: [Evaluation of the interest of procalcitonin in the diagnosis of XXXX in preterm premature @entity2 . An observational and prospective study].

answer: @entity5


abstract: BACKGROUND: Cardiac resynchronization therapy defibrillator can terminate @entity4 ( @entity4 ) and @entity4 ( @entity4 ) via antitachycardia pacing (ATP). OBJECTIVES: We evaluated efficacy and safety of ATP, whether ATP induces @entity1 after inappropriate ATP or @entity2 ( @entity2 ) after appropriate ATP, and whether ATP is associated with mortality. METHODS: A total of 1404 @entity0 with a cardiac resynchronization therapy defibrillator were followed in a prospective multicenter observational research. All-cause mortality rates were estimated in @entity0 subgroups in order to uncouple the trigger ( @entity4 / @entity4 or other rhythms causing inappropriate detections) from ATP therapy. RESULTS: Over a median follow-up of 31 months, 2938 @entity4 / @entity4 episodes were treated with ATP in 360 @entity0 . The adjusted ATP success rate was 63% (95% confidence interval [CI] 57%-69%) on FVTs and 68% (95% CI 62%-74%) on VTs. Acceleration occurred in 55 (1.87%) and @entity3 in 4 (0.14%) of all ATP-treated episodes. In 14 true @entity4 / @entity4 episodes in 5 @entity0 , @entity2 followed ATP therapy. In 4 episodes in 2 @entity0 , @entity4 followed ATP inappropriately applied during @entity2 . Death rate per 100 @entity0 -years was 5.6 (95% CI 4.3-7.5) in @entity0 with appropriate ATP and 1.5 (95% CI 0.4-6.1) in @entity0 with inappropriate ATP (P = .045). CONCLUSION: ATP was effective in terminating @entity4 / @entity4 episodes and displayed a good safety profile. ATP therapies by themselves did not increase death risk; prognosis was indeed better in @entity0 without arrhythmic episodes, even if they received inappropriate ATP, than in @entity0 with ATP on @entity4 / @entity4 episodes. Adverse outcomes observed in @entity0 receiving implantable cardioverter-defibrillator therapies are probably related to the @entity1 itself, a marker of disease progression, rather than to adverse effects of ATP.

title: Ventricular antitachycardia pacing therapy in XXXX with heart failure implanted with a cardiac resynchronization therapy defibrillator device: Efficacy, safety, and impact on mortality.

answer: @entity0


abstract: @entity1 concentration is the key determinant for red skin color in pear fruit. However, the molecular basis for development of red skin is complicated and has not been well-understood thus far. "Starkrimson" (Pyrus communis L.), an introduced red pear cultivated in the north of China and its green mutant provides a desirable red/green pair for identification of candidate genes involved in color variation. Here, we sequenced and annotated the transcriptome for the red/green color mutant at three stages of development using Illumina RNA-seq technology. The total number of mapped reads ranged from 26 to 46 million in six libraries. About 70.11-71.95% of clean reads could be mapped to the reference genome. Compared with green colored fruit, a total of 2230 differentially expressed genes (DEGs) were identified in red fruit. Gene Ontology (GO) terms were defined for 4886 differential transcripts involved in 15 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Three DEGs were identified as candidate genes in the @entity0 pathway, LAR, ANR, and C3H. Tellingly, higher expression was found for genes encoding ANR and LAR in the green color mutant, promoting the @entity3 (PA) pathway and leading to lower @entity1 . MYB-binding cis-motifs were identified in the promoter region of LAR and ANR. Based on these findings, we speculate that the regulation of PA biosynthesis might be a key factor for this red/green color mutant. Besides the known MYB and MADS transcription families, two new families, @entity2 and WRKY, were identified as having high correlation with @entity1 biosynthesis in red skinned pear. In addition, qRT-PCR was used to confirm the transcriptome results for 17 DEGs, high correlation of gene expression, further proved that @entity2 and WARK regulated the @entity1 biosynthesis in red skinned "Starkrimson," and ANR and LAR promote PA biosynthesis and contribute to the green skinned variant. This study can serve as a valuable new resource laying a solid foundation for functional gene identification in the @entity1 pathway of red-skinned pear and provide a good reference for relevant research on molecular mechanisms of color variation in other pear species.

title: Transcriptome profiling reveals differential gene expression in XXXX biosynthesis associated with red/green skin color mutant of pear (Pyrus communis L.).

answer: @entity3


abstract: Objective. @entity2 ( @entity2 ) has traditionally been considered to have analgesic and anti-inflammatory effects. We conducted the first meta-analysis evaluating its benefits for @entity0 with @entity4 ( @entity3 ). Methods. We searched three English and four Chinese databases through October, 2014. Randomized trials evaluating at least 2 weeks of @entity2 for knee @entity3 were selected. The effects of @entity2 on clinical symptoms included both @entity1 level (via the visual analog scale) and total effectiveness rate, which assessed @entity1 , physical performance, and wellness. We performed random-effects meta-analyses using mean difference. Results. Fifteen studies totaling 1618 subjects met eligibility criteria. Bath prescription included, on average, 13 Chinese herbs with directions to steam and wash around the knee for 20-40 minutes once or twice daily. Mean treatment duration was 3 weeks. Results from meta-analysis showed superior @entity1 improvement (mean difference = -0.59 points; 95% confidence intervals [CI], -0.83 to -0.36; p < 0.00001) and higher total effectiveness rate (risk ratio = 1.21; 95% CI, 1.15 to 1.28; p < 0.00001) when compared with standard western treatment. No serious adverse events were reported. Conclusion. @entity2 may be a safe, effective, and simple alternative treatment modality for knee @entity3 . Further rigorously designed, randomized trials are warranted.

title: Chinese Herbal Bath Therapy for the Treatment of Knee XXXX : Meta-Analysis of Randomized Controlled Trials.

answer: @entity3


abstract: BACKGROUND: Lumbosacral transitional vertebrae (LSTV) are increasingly recognized as a common anatomical variant associated with altered patterns of degenerative spine changes. This review will focus on the clinical significance of LSTV, disruptions in normal spine biomechanics, imaging techniques, diagnosis, and treatment. METHODS: A Pubmed search using the specific key words "LSTV," "lumbosacral transitional vertebrae," and " @entity2 " was performed. The resulting group of manuscripts from our search was evaluated. RESULTS: LSTV are associated with alterations in biomechanics and anatomy of spinal and paraspinal structures, which have important implications on surgical approaches and techniques. LSTV are often inaccurately detected and classified on standard AP radiographs and MRI. The use of whole-spine images as well as geometric relationships between the sacrum and lumbar vertebra increase accuracy. Uncertainty regarding the cause, clinical significance, and treatment of LSTV persists. Some authors suggest an association between LSTV types @entity3 . Pseudoarticulation between the transverse process and the sacrum creates a "false joint" susceptible to arthritic changes and @entity5 formation potentially leading to nerve root entrapment. The diagnosis of symptomatic LSTV is considered with appropriate @entity0 history, imaging studies, and diagnostic injections. A positive radionuclide study along with a positive effect from a local injection helps distinguish the transitional vertebra as a significant @entity1 source. Surgical resection is reserved for a subgroup of LSTV @entity0 who fail conservative treatment and whose @entity1 is definitively attributed to the @entity4 . CONCLUSIONS: Due to the common finding of @entity3 and the wide prevalence of LSTV in the general population, it is essential to differentiate between symptoms originating from an anomalous psuedoarticulation from other potential sources of @entity3 . Further studies with larger sample sizes and longer follow-up time would better demonstrate the effectiveness of surgical resection and help guide treatment.

title: A Review of Symptomatic Lumbosacral Transitional Vertebrae: XXXX .

answer: @entity2


abstract: Two hundred fifty radical neck dissections, undertaken for mucosal @entity3 of the head and neck, were reviewed with reference to pathological findings and their clinical implications. No major differences in descriptive surgical pathology were established between irradiated and non-irradiated resections. In general, irradiated dissections had lower total node counts and somewhat fewer nodal metastases involving a smaller number of different nodal groups. The topography of nodal deposits was similar in irradiated and non-irradiated resections. Palpable keratin @entity2 (without intact @entity1 ) were almost confined to irradiated @entity0 . Transcapsular spread of @entity1 from involved lymph nodes was common: it was demonstrated in 160/188 'positive' dissections (85%) and was subclassified as 'macroscopic' in 90 and 'microscopic' in 70. The incidence and extent of transcapsular spread was similar in irradiated and nonirradiated resections. It was more frequently observed in association with large nodal masses but it was also regularly found with small nodal deposits less than 3 cm in diameter. Statistical analyses showed strong associations (p less than 0.0005) between the presence and/or extent of transcapsular spread and subsequent recurrence in the operated neck and overall survival. The predictive value of other clinical and pathological features vis-a-vis local neck recurrence such as numbers of involved nodal groups was weaker. Macroscopic transcapsulr spread emerges as the major prognostic factor for recurrent disease in the neck (p less than 0.0001). Attention is drawn to the advantages of accurate descriptive categories ('macroscopic', 'microscopic') for this critical prognostic feature.

title: Radical neck dissections for XXXX : pathological findings and their clinical implications with particular reference to transcapsular spread.

answer: @entity3


abstract: Far-field recordings of short latency auditory responses were characterized in the White Leghorn @entity0 ( @entity0 , 2-3 weeks post hatch). Six to twelve positive peaks were normally present within the first 8 ms following the onset of a click stimulus (stimulus intensity = 99.0 +/- 6.3 dB pe SPL, 44.3 +/- 1.2 dB SL). Both @entity1 ( @entity1 ) and neural response components were distinguished based on functional criteria. Neural responses (P1a-P6b) were readily masked by white noise. @entity1 responses were resistant to masking and inverted when click polarity was reversed. Systemic cooling produced shifts in neural response latencies such that later peaks (e.g. latencies greater than or equal to P3) were delayed to a greater extent than early peaks (P1a and P2a). The latencies of @entity1 components were relatively unaffected by cooling. The mean latencies and amplitudes were described quantitatively for dominant positive peaks. The mean auditory response threshold for 18 animals was 54.5 +/- 7 dB pe SPL. Dominant later components (P3a and the P3b/P4a complex) were the first to disappear after lethal injection of anesthetic. These were followed immediately by earlier neural peaks. @entity1 components were the last to disappear. A working hypothesis is advanced regarding the distinction between central (P3a, P3b and P4a) and peripheral (P1a, P2a) neural components.

title: Far-field recordings of short latency auditory responses in the White Leghorn XXXX .

answer: @entity0


abstract: Lutropin (LH) receptor was solubilized from pseudopregnant @entity3 ovaries and purified by two cycles of affinity chromatography on @entity0 choriogonadotropin (hCG)-Affi-Gel 10. The purified receptor preparation contained a single class of high-affinity 125I-hCG binding sites with an equilibrium dissociation constant (Kd) of 5.1 X 10(-10) M (at 20 degrees C) and had a specific hormone binding capacity of 7920 pmol/mg of protein. The purified receptor migrated as a single 90-kDa band in @entity6 - @entity5 gel electrophoresis under both nonreducing and reducing conditions. Affinity cross-linking of the purified receptor to 125I-hCG produced a 130-kDa complex. Hormone-binding ability of the purified 90-kDa polypeptide was demonstrated also by ligand blotting. The purified receptor was electroblotted onto @entity9 after @entity6 - @entity5 gel electrophoresis under nonreducing conditions followed by incubation with 125I-hCG. Autoradiography revealed labeling of a 90-kDa band. This labeling was displaced by unlabeled hCG and @entity0 LH but not by @entity0 follitropin or @entity3 prolactin. In addition, LH receptors of @entity4 corpora lutea and @entity2 @entity1 cells were shown by ligand blotting to contain a 90-kDa hormone binding unit, suggesting that @entity8 structure is well conserved among @entity0 species. The purified @entity3 ovarian @entity8 bound to immobilized @entity7 germ agglutinin, implying that the receptor is a glycoprotein. These results demonstrate that the hormone-binding unit of @entity3 ovarian @entity8 is a 90-kDa membrane glycopolypeptide.

title: Purification and partial characterization of XXXX ovarian lutropin receptor.

answer: @entity3


abstract: A two-compartment activity box is described in which the actions of anxiolytic compounds may be readily detected. The box is designed with a partition which divides a dimly-lit black area and a brightly-illuminated white area. Free access to each section is enabled by means of a small opening in the partition. Measures of locomotion and rearing are recorded as well as transitions from black to white and vice versa. Time spent in each section is also measured. In this situation @entity0 demonstrated a clear preference for the dim black section, a finding not inconsistent with the nocturnal nature of this species. By contrast, treatment with @entity2 (0.125-5 mg/kg) or @entity5 (0.01-0.1 mg/kg) produced a significant increase in activity in the white section. Locomotion and rearing in the black section showed a corresponding decrease. @entity3 (0.5-20 mg/kg) and @entity6 (0.5-40 mg/kg) had similar effects. These actions would appear to be independent of their effects on general activity, as @entity4 (1.25-2.5 mg/kg) increased and @entity1 (0.05-0.2 mg/kg) decreased overall exploratory behaviour in a non-selective manner. These data suggest the "two-compartment activity box" to be a model sensitive to the actions of clinically-active anxiolytics.

title: Actions of @entity3 and XXXX in a simple model of anxiety in @entity0 .

answer: @entity6


abstract: A two-compartment activity box is described in which the actions of anxiolytic compounds may be readily detected. The box is designed with a partition which divides a dimly-lit black area and a brightly-illuminated white area. Free access to each section is enabled by means of a small opening in the partition. Measures of locomotion and rearing are recorded as well as transitions from black to white and vice versa. Time spent in each section is also measured. In this situation @entity0 demonstrated a clear preference for the dim black section, a finding not inconsistent with the nocturnal nature of this species. By contrast, treatment with @entity2 (0.125-5 mg/kg) or @entity5 (0.01-0.1 mg/kg) produced a significant increase in activity in the white section. Locomotion and rearing in the black section showed a corresponding decrease. @entity3 (0.5-20 mg/kg) and @entity6 (0.5-40 mg/kg) had similar effects. These actions would appear to be independent of their effects on general activity, as @entity4 (1.25-2.5 mg/kg) increased and @entity1 (0.05-0.2 mg/kg) decreased overall exploratory behaviour in a non-selective manner. These data suggest the "two-compartment activity box" to be a model sensitive to the actions of clinically-active anxiolytics.

title: Actions of XXXX and @entity6 in a simple model of anxiety in @entity0 .

answer: @entity3


abstract: A two-compartment activity box is described in which the actions of anxiolytic compounds may be readily detected. The box is designed with a partition which divides a dimly-lit black area and a brightly-illuminated white area. Free access to each section is enabled by means of a small opening in the partition. Measures of locomotion and rearing are recorded as well as transitions from black to white and vice versa. Time spent in each section is also measured. In this situation @entity0 demonstrated a clear preference for the dim black section, a finding not inconsistent with the nocturnal nature of this species. By contrast, treatment with @entity2 (0.125-5 mg/kg) or @entity5 (0.01-0.1 mg/kg) produced a significant increase in activity in the white section. Locomotion and rearing in the black section showed a corresponding decrease. @entity3 (0.5-20 mg/kg) and @entity6 (0.5-40 mg/kg) had similar effects. These actions would appear to be independent of their effects on general activity, as @entity4 (1.25-2.5 mg/kg) increased and @entity1 (0.05-0.2 mg/kg) decreased overall exploratory behaviour in a non-selective manner. These data suggest the "two-compartment activity box" to be a model sensitive to the actions of clinically-active anxiolytics.

title: Actions of @entity3 and @entity6 in a simple model of anxiety in XXXX .

answer: @entity0


abstract: BACKGROUND: Severe @entity1 has been demonstrated to delay @entity2 . The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve on burn-induced @entity2 in @entity0 . METHODS: @entity4 (b-adrenoceptor antagonist) was injected intraperitoneally after the @entity0 underwent @entity1 . All experiments were performed 6 h following burn/sham @entity1 . AEA was performed at bilateral auricular acupoints for 45 min. Electrocardiogram was recorded for 30 min. Plasma hormones were measured; @entity6 expressions in gastric tissue were measured using western blotting and real-time RT-PCR. KEY RESULTS: (i) @entity1 delayed @entity2 (p = 0.006) and AEA increased @entity2 by 49% (p = 0.045). (ii) @entity1 evoked a significant elevation in plasma @entity3 , which was suppressed by AEA. (iii) @entity1 significantly increased protein and mRNA expressions of @entity6 in gastric fundus and antrum. AEA suppressed burn-induced increase in protein expressions, but not mRNA expressions of @entity6 . CONCLUSIONS _ INFERENCES: Burn @entity5 by up-regulating @entity6 attributed to sympathetic overactivity. AEA improves burn-induced delay in @entity2 , possibly mediated via the sympathetic- @entity6 pathway.

title: Auricular vagal nerve stimulation ameliorates burn-induced XXXX via sympathetic- @entity6 pathways in @entity0 .

answer: @entity2


abstract: BACKGROUND: Severe @entity1 has been demonstrated to delay @entity2 . The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve on burn-induced @entity2 in @entity0 . METHODS: @entity4 (b-adrenoceptor antagonist) was injected intraperitoneally after the @entity0 underwent @entity1 . All experiments were performed 6 h following burn/sham @entity1 . AEA was performed at bilateral auricular acupoints for 45 min. Electrocardiogram was recorded for 30 min. Plasma hormones were measured; @entity6 expressions in gastric tissue were measured using western blotting and real-time RT-PCR. KEY RESULTS: (i) @entity1 delayed @entity2 (p = 0.006) and AEA increased @entity2 by 49% (p = 0.045). (ii) @entity1 evoked a significant elevation in plasma @entity3 , which was suppressed by AEA. (iii) @entity1 significantly increased protein and mRNA expressions of @entity6 in gastric fundus and antrum. AEA suppressed burn-induced increase in protein expressions, but not mRNA expressions of @entity6 . CONCLUSIONS _ INFERENCES: Burn @entity5 by up-regulating @entity6 attributed to sympathetic overactivity. AEA improves burn-induced delay in @entity2 , possibly mediated via the sympathetic- @entity6 pathway.

title: Auricular vagal nerve stimulation ameliorates burn-induced @entity2 via sympathetic- XXXX pathways in @entity0 .

answer: @entity6


abstract: BACKGROUND: Severe @entity1 has been demonstrated to delay @entity2 . The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve on burn-induced @entity2 in @entity0 . METHODS: @entity4 (b-adrenoceptor antagonist) was injected intraperitoneally after the @entity0 underwent @entity1 . All experiments were performed 6 h following burn/sham @entity1 . AEA was performed at bilateral auricular acupoints for 45 min. Electrocardiogram was recorded for 30 min. Plasma hormones were measured; @entity6 expressions in gastric tissue were measured using western blotting and real-time RT-PCR. KEY RESULTS: (i) @entity1 delayed @entity2 (p = 0.006) and AEA increased @entity2 by 49% (p = 0.045). (ii) @entity1 evoked a significant elevation in plasma @entity3 , which was suppressed by AEA. (iii) @entity1 significantly increased protein and mRNA expressions of @entity6 in gastric fundus and antrum. AEA suppressed burn-induced increase in protein expressions, but not mRNA expressions of @entity6 . CONCLUSIONS _ INFERENCES: Burn @entity5 by up-regulating @entity6 attributed to sympathetic overactivity. AEA improves burn-induced delay in @entity2 , possibly mediated via the sympathetic- @entity6 pathway.

title: Auricular vagal nerve stimulation ameliorates burn-induced @entity2 via sympathetic- @entity6 pathways in XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity1 group (PcG) proteins are important epigenetic regulatory proteins that modulate the chromatin state through posttranslational histone modifications. These interacting proteins form multimeric complexes that repress gene expression. Thus, PcG proteins are expected to evolve coordinately, which might be reflected in their phylogenetic trees by concordant episodes of positive selection and by a correlation in evolutionary rates. In order to detect these signals of coevolution, the molecular evolution of 17 genes encoding the subunits of five @entity1 repressive complexes has been analyzed in the @entity0 genus. The observed distribution of divergence differs substantially among and along proteins. Indeed, @entity2 is uniformly conserved, whereas only the established protein domains are conserved in other proteins, such as PHO, @entity3 , @entity4 , @entity5 and ASX. Moreover, regions with a low divergence not yet described as protein domains are present, for instance, in @entity6 and @entity7 . Maximum likelihood methods indicate an acceleration in the nonsynonymous substitution rate at the lineage ancestral to the obscura group species in most genes encoding subunits of the Pcl-PRC2 complex and in genes @entity6 , @entity4 and @entity8 . These methods also allow inferring the action of positive selection in this lineage at genes E(z) and @entity6 . Finally, the protein interaction network predicted from the complete proteomes of 12 @entity0 species using a coevolutionary approach shows two tight PcG clusters. These clusters include well-established binary interactions among PcG proteins as well as new putative interactions.Heredity advance online publication, 21 October 2015; doi:10.1038/hdy.2015.91.

title: Adaptive selection and coevolution at the proteins of the @entity1 repressive complexes in XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity1 group (PcG) proteins are important epigenetic regulatory proteins that modulate the chromatin state through posttranslational histone modifications. These interacting proteins form multimeric complexes that repress gene expression. Thus, PcG proteins are expected to evolve coordinately, which might be reflected in their phylogenetic trees by concordant episodes of positive selection and by a correlation in evolutionary rates. In order to detect these signals of coevolution, the molecular evolution of 17 genes encoding the subunits of five @entity1 repressive complexes has been analyzed in the @entity0 genus. The observed distribution of divergence differs substantially among and along proteins. Indeed, @entity2 is uniformly conserved, whereas only the established protein domains are conserved in other proteins, such as PHO, @entity3 , @entity4 , @entity5 and ASX. Moreover, regions with a low divergence not yet described as protein domains are present, for instance, in @entity6 and @entity7 . Maximum likelihood methods indicate an acceleration in the nonsynonymous substitution rate at the lineage ancestral to the obscura group species in most genes encoding subunits of the Pcl-PRC2 complex and in genes @entity6 , @entity4 and @entity8 . These methods also allow inferring the action of positive selection in this lineage at genes E(z) and @entity6 . Finally, the protein interaction network predicted from the complete proteomes of 12 @entity0 species using a coevolutionary approach shows two tight PcG clusters. These clusters include well-established binary interactions among PcG proteins as well as new putative interactions.Heredity advance online publication, 21 October 2015; doi:10.1038/hdy.2015.91.

title: Adaptive selection and coevolution at the proteins of the XXXX repressive complexes in @entity0 .

answer: @entity1


abstract: OBJECTIVES: The most common @entity2 include clear cell, chromophobe, and @entity4 ( @entity4 ) and @entity5 . While lesions containing hybrid features of different @entity1 types, such as @entity1 , have been well documented in the literature, the finding of a collision @entity1 of two distinct @entity1 types- @entity8 and @entity5 -is extremely rare. METHODS: We present a case of @entity8 associated with an @entity5 . Our discussion includes a review of the available literature on this rare type of collision @entity1 . RESULTS: Prosection of a partial nephrectomy performed in a 78-year-old @entity0 for painless gross @entity3 and @entity6 revealed a 6.4 * 5 * 3.6-cm well-delineated orange to yellow-tan mass harboring a white-tan 1 * 0.9 * 0.9-cm mass. Histologic diagnosis of @entity8 associated with an @entity5 was rendered. By immunohistochemistry, focal @entity7 expression was present in the @entity5 , while strong diffuse positive @entity7 expression was present in the @entity8 component. Fluorescence in situ hybridization (FISH) revealed trisomy 17 in 39.3% of @entity8 @entity1 nuclei but no significant chromosomal aberration in @entity5 . CONCLUSIONS: In view of this and previously reported cases, thorough sectioning and examination, especially in large @entity5 , is recommended to exclude the presence of an associated @entity1 . To our knowledge, trisomy 17 by FISH has not been previously reported in these extremely rare @entity1 .

title: A Collision Tumor of XXXX and @entity5 : Case Report and Literature Review.

answer: @entity4


abstract: OBJECTIVES: The most common @entity2 include clear cell, chromophobe, and @entity4 ( @entity4 ) and @entity5 . While lesions containing hybrid features of different @entity1 types, such as @entity1 , have been well documented in the literature, the finding of a collision @entity1 of two distinct @entity1 types- @entity8 and @entity5 -is extremely rare. METHODS: We present a case of @entity8 associated with an @entity5 . Our discussion includes a review of the available literature on this rare type of collision @entity1 . RESULTS: Prosection of a partial nephrectomy performed in a 78-year-old @entity0 for painless gross @entity3 and @entity6 revealed a 6.4 * 5 * 3.6-cm well-delineated orange to yellow-tan mass harboring a white-tan 1 * 0.9 * 0.9-cm mass. Histologic diagnosis of @entity8 associated with an @entity5 was rendered. By immunohistochemistry, focal @entity7 expression was present in the @entity5 , while strong diffuse positive @entity7 expression was present in the @entity8 component. Fluorescence in situ hybridization (FISH) revealed trisomy 17 in 39.3% of @entity8 @entity1 nuclei but no significant chromosomal aberration in @entity5 . CONCLUSIONS: In view of this and previously reported cases, thorough sectioning and examination, especially in large @entity5 , is recommended to exclude the presence of an associated @entity1 . To our knowledge, trisomy 17 by FISH has not been previously reported in these extremely rare @entity1 .

title: A Collision Tumor of @entity4 and XXXX : Case Report and Literature Review.

answer: @entity5


abstract: OBJECTIVES: Gastrointestinal involvement of Beh  et's syndrome is usually treated with glucocorticoids, @entity6 compounds and @entity4 . However, some @entity0 are refractory to these conventional therapy modalities. In this paper we report our experience on 13 @entity0 with @entity3 of Beh  et's syndrome who were refractory to the conventional therapy and who were treated with @entity2 antagonists and/or @entity5 . METHODS: We reviewed the charts of our Beh  et's syndrome @entity0 with @entity3 and identified those who were treated with @entity2 antagonists and/or @entity5 . Demographic features, previous and concomitant drugs, previous surgery, time to remission and duration of remission were tabulated. We also performed a systematic review of publications on @entity3 of Beh  et's syndrome @entity0 treated with @entity2 antagonists and/or @entity5 . RESULTS: Among our 64 @entity0 with @entity3 of Beh  et's syndrome, we identified 13 (20%) (7 @entity0 , 6 @entity0 , mean age 27.4    9.4) who had been treated with @entity2 antagonists and/or @entity5 . Their previous medications were glucocorticoids (13/13), @entity4 (13/13), @entity6 derivatives (3/13) and @entity7 (1/13). Clinical and endoscopic remission was obtained in 10 @entity0 . One @entity0 died with @entity1 . The systematic literature search revealed 91 cases who had used @entity2 antagonists and 15 who had used @entity5 . Among the @entity0 who had received @entity2 antagonists, clinical remission was obtained in 47/91 @entity0 (51%), while endoscopic remission was observed in 21/46 (45%) who had a control colonoscopy. CONCLUSIONS: One fifth of our Beh  et's syndrome @entity0 with @entity3 were refractory to conventional treatment modalities. Remission was obtained with @entity2 antagonists and/or @entity5 in about 75% of the cases.

title: @entity2 antagonists and XXXX for the management of gastrointestinal Beh  et's syndrome refractory to the conventional treatment modalities: a case series and review of the literature.

answer: @entity5


abstract: OBJECTIVES: Gastrointestinal involvement of Beh  et's syndrome is usually treated with glucocorticoids, @entity6 compounds and @entity4 . However, some @entity0 are refractory to these conventional therapy modalities. In this paper we report our experience on 13 @entity0 with @entity3 of Beh  et's syndrome who were refractory to the conventional therapy and who were treated with @entity2 antagonists and/or @entity5 . METHODS: We reviewed the charts of our Beh  et's syndrome @entity0 with @entity3 and identified those who were treated with @entity2 antagonists and/or @entity5 . Demographic features, previous and concomitant drugs, previous surgery, time to remission and duration of remission were tabulated. We also performed a systematic review of publications on @entity3 of Beh  et's syndrome @entity0 treated with @entity2 antagonists and/or @entity5 . RESULTS: Among our 64 @entity0 with @entity3 of Beh  et's syndrome, we identified 13 (20%) (7 @entity0 , 6 @entity0 , mean age 27.4    9.4) who had been treated with @entity2 antagonists and/or @entity5 . Their previous medications were glucocorticoids (13/13), @entity4 (13/13), @entity6 derivatives (3/13) and @entity7 (1/13). Clinical and endoscopic remission was obtained in 10 @entity0 . One @entity0 died with @entity1 . The systematic literature search revealed 91 cases who had used @entity2 antagonists and 15 who had used @entity5 . Among the @entity0 who had received @entity2 antagonists, clinical remission was obtained in 47/91 @entity0 (51%), while endoscopic remission was observed in 21/46 (45%) who had a control colonoscopy. CONCLUSIONS: One fifth of our Beh  et's syndrome @entity0 with @entity3 were refractory to conventional treatment modalities. Remission was obtained with @entity2 antagonists and/or @entity5 in about 75% of the cases.

title: XXXX antagonists and @entity5 for the management of gastrointestinal Beh  et's syndrome refractory to the conventional treatment modalities: a case series and review of the literature.

answer: @entity2


abstract: In an automatized experiment, with a computer on line, amplitude-temporal parameters of evoked potentials (EPs) to purposive and non-purposive stimuli (digits), were analyzed in normal and @entity1 @entity0 . At unilateral stimuli presentation to the left or right visual half-fields EPs were recorded simultaneously in projection, @entity2 , parietal and central areas of the left and right hemispheres. It has been shown that in normal @entity0 , differential involvement of projection and associative structures in the analysis of sensory information takes place in both hemispheres. The amplitudes of most EP components in the range of 100-400 ms to the purposive stimuli are higher than to the non-purposive ones. Considerable similarity of EPs developing in response to ipsi- and contralateral stimulations of visual fields ("direct" and "transmitted" EP) is observed. In @entity1 @entity0 significant changes are revealed in intra- and interhemisphere organization of the process of perception of purposive and non-purposive stimuli. In the right hemisphere structures there are no differential EP reactions to the two types of stimuli. Significant, in comparison with the norm, prolongation of the latencies of most EP components is noted, especially in the structures of the left hemisphere, to the purposive stimuli. In the process of perception, changes are seen of the integration of functions of both hemispheres. The totality of disturbances of systemic brain organization at perceptive activity in @entity1 @entity0 may reflect neurophysiological mechanisms of @entity1 .

title: [Electrophysiologic analysis of the process of recognizing target and non-target stimuli in healthy and oligophrenic XXXX ].

answer: @entity0


abstract: BACKGROUND: The long-term recurrence rate of @entity0 with obscure @entity3 (OGIB) who underwent video capsule endoscopy (VCE) remains unknown. Our study aimed to identify the cumulative incidence of rebleeding, develop a predictive model of rebleeding, and evaluate whether the model can be applied in other outcomes among @entity0 with OGIB. METHODS: We conducted a multicenter retrospective cohort study of 320 @entity0 with OGIB who underwent VCE between 2009 and 2014. A rebleeding model was developed using multivariate Cox proportional hazards analysis and evaluated using Harrell's c-index. RESULTS: Rebleeding occurred in 43 @entity0 (13.4%) during a mean follow-up period of 18.3 (standard error, 0.9) months. The rebleeding sources were the small intestine (n   =   17), extra-small intestine (n   =   13), and unknown (n   =   13). The cumulative incidence of rebleeding was 11.0% at 12   months and 35.3% at 60   months. Multivariate analysis revealed that female, liver @entity1 , @entity5 use, overt @entity4 , and positive VCE findings were significant predictors of rebleeding. The rebleeding rate was 0% in @entity0 with no predictors and 40% in @entity0 with full predictors (p   <   0.01). The model presented a high predictive accuracy (c-statistic, 0.733). @entity0 with higher predictors exhibited higher transfusion requirements, longer length of stay, and higher mortality (p   <   0.01). CONCLUSION: The cumulative incidence of rebleeding at 12 and 60   months was 11.0% and 35.3%, respectively. Five factors enable prediction of not only rebleeding, but also transfusion requirements, length of stay, and @entity2 in OGIB @entity0 . This article is protected by copyright. All rights reserved.

title: A new predictive model of rebleeding during follow-up of patents with obscure XXXX : A multicenter cohort study.

answer: @entity3


abstract: PURPOSE: To describe the outcome in @entity0 of eyes with @entity4 following repeated treatment with @entity3 (Ozurdex) implants. DESIGN: Retrospective, interventional study. METHODS: Twenty-two eyes of 16 pediatric @entity0 with @entity4 were treated with 35 @entity3 implants at a tertiary referral center. Following implantations, anatomic and functional outcomes, as well as @entity6 , were noted. Main outcome measures included best-corrected visual acuity, central retinal thickness, number and dosage of systemic immunosuppression drugs, vitreous haze score, and presence of raised intraocular pressure or @entity2 . RESULTS: Following the first implantation, average best-corrected visual acuity improved significantly from 0.55    0.08 logMAR to 0.37    0.08 logMAR (P  =  .024), central retinal thickness decreased by 219    55   m (P  = .01), and the percentage of eyes achieving a vitreous haze score of 0 increased from 41% to 88% (P  = .006). The median time to relapse following the first injection was 9  months, with a similar response achieved after each repeat implantation. @entity0 previously requiring systemic immunosuppression at the time of the first implantation were able to stop or significantly reduce the dose and number of drugs. In total there were 4  instances of @entity2 progression that were not visually significant and did not require surgical treatment and 6 cases of raised IOP, 5 of which were treated pharmacologically with no surgical intervention required and 1 that required revision of a previous filtration surgery. There were no cases of implant migration into the anterior chamber, @entity7 , or @entity5 . CONCLUSIONS: The use of @entity3 implants in @entity0 results in improved retinal thickness and @entity1 , which can improve vision for  several months. Repeat implantations result in continued control of the @entity1 , allowing for reduction of systemic immunosuppression with few @entity6 .

title: Outcome of Treating XXXX With @entity3 Implants.

answer: @entity4


abstract: PURPOSE: To describe the outcome in @entity0 of eyes with @entity4 following repeated treatment with @entity3 (Ozurdex) implants. DESIGN: Retrospective, interventional study. METHODS: Twenty-two eyes of 16 pediatric @entity0 with @entity4 were treated with 35 @entity3 implants at a tertiary referral center. Following implantations, anatomic and functional outcomes, as well as @entity6 , were noted. Main outcome measures included best-corrected visual acuity, central retinal thickness, number and dosage of systemic immunosuppression drugs, vitreous haze score, and presence of raised intraocular pressure or @entity2 . RESULTS: Following the first implantation, average best-corrected visual acuity improved significantly from 0.55    0.08 logMAR to 0.37    0.08 logMAR (P  =  .024), central retinal thickness decreased by 219    55   m (P  = .01), and the percentage of eyes achieving a vitreous haze score of 0 increased from 41% to 88% (P  = .006). The median time to relapse following the first injection was 9  months, with a similar response achieved after each repeat implantation. @entity0 previously requiring systemic immunosuppression at the time of the first implantation were able to stop or significantly reduce the dose and number of drugs. In total there were 4  instances of @entity2 progression that were not visually significant and did not require surgical treatment and 6 cases of raised IOP, 5 of which were treated pharmacologically with no surgical intervention required and 1 that required revision of a previous filtration surgery. There were no cases of implant migration into the anterior chamber, @entity7 , or @entity5 . CONCLUSIONS: The use of @entity3 implants in @entity0 results in improved retinal thickness and @entity1 , which can improve vision for  several months. Repeat implantations result in continued control of the @entity1 , allowing for reduction of systemic immunosuppression with few @entity6 .

title: Outcome of Treating @entity4 With XXXX Implants.

answer: @entity3


abstract: Epidemiologic studies of the relationships between vitamins and 3 types of @entity2 are reviewed. First, the widely reported association between @entity6 and @entity8 and risk of @entity1 is considered. In a large population-based case-control study of @entity1 among white males in New Jersey, increased intake of vegetables, dark green vegetables, dark yellow-orange vegetables, and carotenoids were each associated with reduced risk, but intake of @entity6 or total @entity6 was not related. The protective effect of vegetables was limited to current and recent cigarette smokers, which suggests that vegetable intake prevents a late-stage event in @entity3 . Consumption of dark yellow-orange vegetables was consistently more predictive of reduced risk than either the total carotenoid index or consumption of any other food group, possible because of the high content of @entity8 in this food group. The results and limitations of other epidemiologic studies of diet and @entity1 are reviewed. Second, the evolving relationship between multiple micronutrient @entity4 is discussed. In a death certificate-based case-control study of @entity4 in black males in Washington, D.C., several indicators of general nutritional status, including consumption of fresh or frozen meat and fish, dairy products and eggs, and fruit and vegetables, and the number of meals eaten per day, were inversely and independently correlated with the risk of @entity4 . Estimates of intake of micronutrients, such as carotenoids, @entity5 , @entity11 , and @entity10 , were less strongly associated with reduced risk than were the broad food groups that provide most of each micronutrient. Thus no single micronutrient deficiency was identified. Other studies suggest that generally poor nutrition may partially explain the susceptibility of urban black @entity0 to @entity4 . Finally, the postulated association between low @entity7 levels and risk of @entity2 is examined. Among @entity0 who use oral contraceptives, serum and red blood cell folacin levels were reported to be lower among those with @entity9 . In a clinical trial involving oral contraceptive users, @entity9 gradually decreased in the group supplemented with oral @entity7 but remained unchanged in the group given the placebo. Other epidemiologic studies of diet and @entity2 are discussed.

title: Epidemiologic studies of vitamins and XXXX , esophagus, and cervix.

answer: @entity1


abstract: Infection by Strongyloides stercoralis is a highly prevalent @entity7 , which is mostly distributed in the tropical and subtropical regions of the world. Although a substantial number of cases are asymptomatic or paucisymtomatic, severe and life-threatening forms of this @entity2 still occur and not infrequently is lately diagnosed. Gram-negative bacteria @entity3 , which frequently accompanies the severe @entity7 , contributes to the high mortality rate. Severe @entity2 is invariably triggered by any imbalance in the host's immunity, favoring the auto-infective cycle, which increases the intraluminal parasite burden enormously. Clinical presentation of severe cases is varied, and diagnosis requires a high suspicion index. Acute abdomen has been reported in association with S. stercoralis @entity2 , but intestinal @entity1 is rarely found during the surgical approach. The authors report the case of a @entity0 who sought the emergency unit with recent onset @entity4 . Clinical and imaging features were consistent with obstructive acute abdomen. Scattered adhesions and a necrotic ileal segment with a tiny perforation represented the surgical findings. The @entity0 outcome was unfavorable and respiratory distress required an open lung biopsy. Both surgical specimens showed S. stercoralis @entity2 . Unfortunately the @entity0 underwent @entity5 and @entity3 , and subsequently died. The authors call attention to the finding of intestinal @entity1 and @entity6 as possibilities for the diagnosis and risk factor, respectively, for a severe @entity2 of S. stercoralis.

title: Strongyloides stercoralis hyperinfection associated with XXXX .

answer: @entity6


abstract: OBJECTIVE: To describe glucagon prescription patterns in @entity0 with type 1 (T1DM) or type 2 @entity1 (T2DM) who received an initial insulin prescription. METHODS: Retrospective analyses were conducted with data from Truven Health MarketScan databases to assess time to glucagon prescriptions: filled within 1.5 months after index date (early) or after 1.5 months postindex (nonearly). The index date was the date of first insulin prescription between January 1, 2009 and December 31, 2011; for T2DM, without an insulin prescription in the previous 6 months; for T1DM, @entity1 diagnosis preindex or within 3 months postindex. RESULTS: Analysis included 8,814 @entity0 with T1DM and 47,051 with T2DM (49.3% and 2.4%, respectively) who had glucagon prescriptions filled. The median times to first glucagon prescription were 196 days (T1DM) and 288 days (T2DM). The rates of filling glucagon were highest in the first 1.5 months. The times to first @entity2 -related emergency room (ER) visit for T1DM and T2DM cohorts were initially similar for those with early glucagon versus nonearly glucagon prescriptions. After 10.8 and 2.5 months postindex, respectively, the percentage of @entity2 -related ER visits was lower for those with early glucagon prescriptions. CONCLUSION: Glucagon prescriptions filled for @entity0 with @entity1 who are initiating insulin are low. @entity0 with T1DM who were younger and healthier filled glucagon prescriptions more often; @entity0 with T2DM who were younger and sicker and had a higher percentage of @entity2 -related ER visit history filled glucagon prescriptions more often. Glucagon filled early was associated with a lower incidence of @entity2 -related ER visits. ABBREVIATIONS: ADA = American @entity1 Association CCI = Charlson comorbidity index CI = confidence interval ER = emergency room GBM = gradient boosting method HR = hazard ratio KM = Kaplan-Meier NPH = neutral protamine Hagedorn T1DM = type 1 @entity1 T2DM = type 2 @entity1 .

title: GLUCAGON PRESCRIPTION PATTERNS IN XXXX WITH EITHER TYPE 1 OR 2 DIABETES WITH NEWLY PRESCRIBED INSULIN.

answer: @entity0


abstract: BACKGROUND: Blue light with peak emission around 460   nm is the preferred treatment of neonatal @entity2 . However, studies using fluorescent light tubes have suggested that turquoise light with peak emission at 490   nm may be more efficient. At present, the predominant light source for phototherapy is @entity3 ( @entity3 ). Hence, the aim of this study was to compare the @entity1 -reducing effect in @entity4 treated either with turquoise or with blue LED light with peak emission at 497 or 459   nm, respectively, with equal irradiance on the @entity0 . METHODS: @entity0 with gestational age >= 33   wk and uncomplicated @entity2 were randomized to either turquoise or blue LED light and were treated for 24   h. The mean irradiance footprint at skin level was 5.2   *   10(15) and 5.1   *   10(15) photons/cm(2)/s, respectively. RESULTS: Forty-six @entity0 received turquoise light and 45 received blue light. The median (95% confidence interval) decrease of total serum @entity1 was 35.3% (32.5; 37.3) and 33.1% (27.1; 36.8) for @entity0 treated with turquoise and blue lights, respectively. The difference was nonsignificant (P = 0.53). The decrease was positively correlated to postnatal age and negatively to birth weight. CONCLUSION: Using LED light of equal irradiance, turquoise and blue lights had equal @entity1 -reducing effect on @entity2 of neonates.

title: Effect of phototherapy with turquoise vs. blue LED light of equal irradiance in XXXX .

answer: @entity4


abstract: UNASSIGNED: The aim of the study was to analyze the local efficacy and eye retention rate after frameless, image-guided robotic radiosurgery against @entity6 . A total of 217 @entity0 , mostly with medium and large unilateral uveal @entity2 (3% small, 62% medium, and 35% large) were treated. The median age was 64 years (range 21-95 years). All @entity0 underwent a single-session procedure beginning with retrobulbar anesthesia, followed by MRI and computerized tomography scanning to generate the treatment plan. The @entity1 dose was 18-22   Gy (mean, 20.3   Gy) prescribed to the 70% isodose line. Follow-up occurred at 3, 6, 12, and 18 months and yearly thereafter with clinical, ultrasound, and MRI studies. The median follow-up time was 26.4 months. All @entity0 were treated in the frameless setup within 3   h. The actuarial 3- and 5-year eye retention rates were 86.7 and 73%, respectively. Local control at 3 and 5 years was 87.4 and 70.8%, respectively. Serviceable vision was maintained in 30.9% of @entity0 at last follow-up. Treatment-induced @entity4 developed in 33 @entity0 at a median 20.8 months (range, 5.8-54.0 months). Other adverse effects were @entity3 (26 @entity0 ) and @entity5 (seven @entity0 ). Frameless, single-session, image-guided robotic radiosurgery is an effective and straightforward treatment option for @entity0 with medium and large @entity6 that are otherwise difficult to treat.

title: Robotic radiosurgery for the treatment of medium and large XXXX .

answer: @entity6


abstract: There were 16 cases of orbital recurrence in a consecutive series of 317 @entity0 with @entity4 referred to a specialist centre. The incidence of orbital relapse amongst @entity0 treated at the centre from the outset of their disease was 2.5%. In every case the @entity0 was the first affected family member. The @entity1 was therefore not anticipated and had commonly been detected at an advanced stage. Systemic staging investigations detected extraorbital spread in six of the 16 and none of these @entity0 survived. One of the remaining ten @entity0 with no evidence of dissemination at the time of diagnosis of orbital recurrence is a long-term survivor. No @entity0 survived after orbital exenteration or radical orbital radiotherapy alone. Three @entity0 received a combination of radiotherapy and adjuvant chemotherapy. Only one of the three was free from @entity3 at relapse and this @entity0 is the only survivor. In @entity0 apparently free from widespread @entity4 at diagnosis of orbital recurrence, distant relapse was the commonest cause of @entity2 though several @entity0 died from direct intracranial extension. It is advocated that orbital recurrence of @entity4 is treated by excision biopsy of the @entity1 mass followed by radical orbital radiotherapy to a dose of 50 Gy. This should be combined with adjuvant chemotherapy and, where a risk of direct intracranial extension exists, by neuraxis irradiation. No other @entity0 in this series with evidence of local extraocular extension of @entity4 at enucleation and who had received radical orbital radiotherapy to a full dose of 50 Gy subsequently recurred in the orbit.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Orbital recurrence of XXXX .

answer: @entity4


abstract: @entity3 ( @entity3 ) is a disorder characterized by unilateral involuntary @entity4 of the muscles innervated by the facial nerve (cranial nerve VII). The etiology is often a redundant or ectatic artery in the cerebellopontine angle that compresses the facial nerve. Neurosurgical decompression with implantation of a sponge between the ectatic artery and the facial nerve produces good results, but has a high complication rate and a poor @entity0 acceptance rate. Various modes of peripheral neurectomy have also been advocated, but the recurrence rate is high and the preexisting functional and cosmetic eyelid deformities are exacerbated. The results of unilateral periorbital myectomy in 21 @entity3 @entity0 are presented. Follow-up ranging from 1 to 7 years was available on 16 @entity0 . Excellent or good results were obtained in 94% of these cases, and @entity2 were minor. Transient @entity5 and forehead anesthesia are the most common complications. An unforseen benefit of periorbital myectomy surgery is the improvement or relief of lower facial contractions that occurred in 75% of @entity0 . The authors believe the myectomy procedure is a safe, effective, predictable therapy for those @entity3 @entity0 unwilling to risk a neurosurgical operation, and allows simultaneous reconstruction of associated eyelid and @entity1 .

title: XXXX . Results of unilateral myectomy.

answer: @entity3


abstract: In a consecutive series of 75 @entity0 with unstable cervical spine injuries treated with halo-vest, 1976-1984, a total of 14 @entity0 (comprising 18.7%) had odontoid @entity2 . Of the @entity0 with odontoid @entity2 , 1 @entity0 had an incomplete @entity3 . All @entity0 except 1 were treated within the first day after the @entity1 . A total of 50% were injured in motor vehicle accidents. The odontoid fracture was reduced by skull traction and then stabilized with a halo-vest for 12 weeks. One @entity0 died within the first 2 weeks after the injury. There were no other serious complications during the treatment. The initial dislocation and reduction was studied. Ten @entity0 were followed-up after 2 years. Another 2 @entity0 died of other causes during that time. One had an Anderson-d'Alonzo @entity2 that failed to unite. Different prognostic factors were analyzed. @entity2 gap and fracture type may have contributed to nonunion. Only 1 @entity0 was totally free from symptoms after 2 years. The halo-vest was well tolerated in all @entity0 and assured a high percentage of healing.

title: Odontoid XXXX treated with halo-vest.

answer: @entity2


abstract: It has been found in our laboratory that compression induces disaggregation and decompression induces aggregation of @entity0 platelets. The experimental design was based on the premise that oppositely charged @entity1 residues of @entity3 are juxtaposed in the specific adhesive site(s). This can be explained by the principle of Le Chateller. Under compression, electrically charged groups gain layers of water molecules which are radially oriented and pulled in closer to the center of the charge, thus making the layer more compact. This increases the thickness of the shield, thus inactivating or disaggregating the platelets. Conversely, decompression drives the water away from the compact shield; water molecules are randomized into the bulk phase; the shield becomes thinner, thus permitting spontaneous aggregation of platelets. It is well known that increasing the concentration of neutral salt can inhibit @entity2 . This is due to the increase of ionic strength which attenuates the electric charge and thickens the shield. Molecules having a large electric dipole moment can inhibit @entity2 by a similar mechanism. It is generally accepted that @entity3 is involved in @entity2 . However, it is not known whether or not @entity3 is essential for @entity2 inducible by decompression. Here we present data indicating that @entity3 is essential in decompression-inducible @entity2 . We also present experimental data which show that high hydraulic pressure inhibits @entity2 , consistent with our premise that electrically charged groups are involved in the initial phase of @entity2 .

title: Compression inhibits aggregation of XXXX platelets under high hydraulic pressure.

answer: @entity0


abstract: From February 1983 to December 1985, the authors investigated 19 african @entity0 with @entity4 in Niamey (Republic of @entity2 ). A 15 points diagnostic score was systematically used. Two signs were indispensable for the diagnosis: post-partum agalactia (or severe @entity5 ) and @entity1 . At least 9 points score was found for every case. Eighteen @entity0 lived along a major road in Niamey and in Dosso departments. The prevalence of this disease is probably important but many cases were not diagnosed since there was no medical examination. @entity4 was predominantly diagnosed among Fulani @entity0 . Young @entity0 (mean age: 26 years) in intensive sexual life, primiparous (8/9) or multiparous (11/19) were concerned. Emergence circumstances of signs were: childbirth at home (18/19), severe @entity3 at placental birth (14/19), rare transfusions (2/19). The @entity0 of a mother with @entity4 had a poor prognosis: 9 deaths among 11 deliveries for multiparous, 7/8 for monoparous. The @entity0 were stillborn or more often dead during the first months. Deaths were in relation to absence of maternal lactation. For the primiparous, then infertile @entity0 because of @entity4 , the repudiation becomes often the only social way of life. Lasting hormonotherapy was not available because 18/19 @entity0 were very poor. Prevention is not possible before long, especially in primiparous, because of: the mentality: the first delivery at home with the mother is the traditional habit; the importance of the required measures.

title: [Sheehan syndrome in the Republic of XXXX . 19 cases].

answer: @entity2


abstract: UVB-induced @entity1 , delayed tanning (DT), and UVA-induced immediate tanning (IT) in Japanese were investigated on the skin of the backs of 65 healthy subjects. The subjects were classified according to @entity0 ( @entity0 ) based on personal history of sun-reactivity. Skin color was determined by skin reflectance using a Value Reflex Meter. With monochromatic UVR at wavelengths of 290 and 305 nm, minimal @entity1 dose (MED) and minimal melanogenic dose (MMD) were recorded at 24 h and 7 d after irradiation. Fading response of DT after the sunlamp-irradiation was measured by skin reflectance. Minimal IT dose (MITD) was observed immediately after irradiation with monochromatic UVR at wavelengths of 320, 340, 360, and 400 nm. The MED was exactly correlated with @entity0 . The MED and the MMD increased with increasing @entity0 , and with decreasing skin reflectance. The MMD was greater than the corresponding MED for individuals of all @entity0 classes. The MITD was correlated with neither @entity0 nor skin color. The action spectrum for IT showed a maximum at the wavelength of 320 nm and decreased gradually towards 400 nm.

title: UVB-induced XXXX , delayed tanning, and UVA-induced immediate tanning in Japanese skin.

answer: @entity1


abstract: The prevalence of @entity2 in fundic @entity6 is probably greater than previously recognized. To help elucidate the clinicopathology of this syndrome, we report a series of 11 @entity0 with solitary or multicentric @entity1 . In these @entity0 , basal @entity7 levels and density of fundic mucosal endocrine cells were greater than that for @entity0 with uncomplicated fundic @entity6 (p = 0.02 and p = 0.002, respectively). The @entity1 , of which the largest measured 30 mm, frequently showed characteristic endoscopic features. They were all situated in the fundic mucosa, which showed micronodular endocrine cell @entity4 . Small, endoscopically evident tumorlets, or "early @entity5 ," limited to the lamina propria were observed in some @entity0 . These lesions may represent intermediate stages between micronodules and invasive @entity5 , all of which infiltrated at least into the muscularis mucosae of the gastric wall. Although some consistent characteristics features were noted, there were structural variations. The cells were argyrophil but nonargentaffin and did not stain with conventional mucus stains. They did not stain significantly for @entity3 ( @entity3 ). The secretory product of these @entity1 remains to be identified. Ultrastructurally, some @entity1 were mainly composed of enterochromaffinlike (ECL) cells, but in other @entity1 most of the cells could not be classified.

title: XXXX associated with the syndrome of hypergastrinemic @entity6 . A prospective analysis of 11 cases.

answer: @entity2


abstract: The prevalence of @entity2 in fundic @entity6 is probably greater than previously recognized. To help elucidate the clinicopathology of this syndrome, we report a series of 11 @entity0 with solitary or multicentric @entity1 . In these @entity0 , basal @entity7 levels and density of fundic mucosal endocrine cells were greater than that for @entity0 with uncomplicated fundic @entity6 (p = 0.02 and p = 0.002, respectively). The @entity1 , of which the largest measured 30 mm, frequently showed characteristic endoscopic features. They were all situated in the fundic mucosa, which showed micronodular endocrine cell @entity4 . Small, endoscopically evident tumorlets, or "early @entity5 ," limited to the lamina propria were observed in some @entity0 . These lesions may represent intermediate stages between micronodules and invasive @entity5 , all of which infiltrated at least into the muscularis mucosae of the gastric wall. Although some consistent characteristics features were noted, there were structural variations. The cells were argyrophil but nonargentaffin and did not stain with conventional mucus stains. They did not stain significantly for @entity3 ( @entity3 ). The secretory product of these @entity1 remains to be identified. Ultrastructurally, some @entity1 were mainly composed of enterochromaffinlike (ECL) cells, but in other @entity1 most of the cells could not be classified.

title: @entity2 associated with the syndrome of hypergastrinemic XXXX . A prospective analysis of 11 cases.

answer: @entity6


abstract: @entity0 were treated with @entity5 , a hypolipidemic drug, and with @entity3 . Both drugs which are known to cause peroxisome proliferation, and a concomitant increase in peroxisomal @entity1 beta-oxidation activity in liver increased one of the major integral peroxisomal membrane polypeptides (PMPs), with apparent molecular mass of 69-kDa, six- and twofold, respectively. On the other @entity2 caused a decrease in peroxisomal @entity1 beta-oxidation activity and considerably lowered the concentration of @entity6 69 in the peroxisomal membrane. Two other PMPs with apparent molecular masses of 36 and 22 kDa were not influenced by these treatments. The PMPs with apparent molecular masses of 42, 28, and 26 kDa were shown to be derived from the 69-kDa polypeptide by the activity of a yet uncharacterized endogenous protease during isolation of peroxisomes. Limited proteolysis of intact peroxisomes using proteinase K and subtilisin further substantiated that some portion of the 69-kDa polypeptide extends into the cytoplasm. The 36- and the 22-kDa polypeptides were accessible to proteolytic attack to a much lower extent and, therefore, are supposed to be rather deeply embedded within the peroxisomal membrane. It is demonstrated that peroxisomal @entity4 synthetase, an integral PMP extending partially into the cytoplasm, and PMP 69 are not identical polypeptides. Comparison of the peroxisomal membrane with that of mitochondria and microsomes revealed that the 69- and 22-kDa polypeptides as well as the bifunctional protein of the peroxisomal @entity1 beta-oxidation pathway were specifically located only in peroxisomes. Considerable amounts of a polypeptide cross-reacting with the antiserum against the 36-kDa polypeptide were found in mitochondria.

title: Integral membrane polypeptides of XXXX liver peroxisomes: topology and response to different metabolic states.

answer: @entity0


abstract: Epidemiological studies related to the occurrence of @entity1 commonly use symptom check-lists. The results of such studies depend on, amongst others, the construction of the questionnaire and especially on the specification of the value of the questionnaire (GSI) which is determined as the boundary between the "psychophysiological" or organic symptoms and @entity1 . A control study was carried out on the norms of two symptom checklists which have been used for many years in Poland: SCL-"S" (73 symptoms), most often diagnosed in @entity1 @entity0 , at the time of constructing the questionnaire and the SCL-"O" (the same 73 + 62 other symptoms). The criterion population was made up of 843 untreated subjects and 2026 @entity0 of day-hospitals. The norms specified by the method of finding the "optimal cut-off point" were approx. 5% in the SCL-"S" and 3% in the SCL-"O" higher for the cohort of @entity0 than for @entity0 . According to those norms, about 30% of the untreated population gains the same result of Global Severity Index (GSI) as about 90% of @entity0 treated for @entity1 and could be diagnosed as @entity1 . The GSI norms for the SCL-"S" more often indicated the existence of these disorders in the group of untreated @entity0 than in the @entity0 's group, while the norms of SCL-"O" indicate a similar frequency of the disease independently of the gender. The symptom frequency analysis presenting differences in the @entity0 (1165 ss.) and @entity0 (861 ss.) @entity0 groups and lead also to the hypothesis on the dependency of such epidemiological data on the construction of the symptom check-lists--especially the number of variables concerning symptoms more frequent in the female and/or in the male populations.

title: [Symptom check-lists in the diagnosis and epidemiology of XXXX ].

answer: @entity1


abstract: The effect of a @entity1 occurring after injection of @entity6 @entity2 on the occurrence of different @entity5 is a subject of the paper. 31 clinical cases, in which during the @entity2 treatment the said reaction took place, were analysed. It has been found that the most often found consequence of that treatment is conversive @entity7 , and subsequently the @entity8 . On an average an @entity1 occurred after the sixth injection. In 94% of the @entity0 the @entity5 appeared immediately after the described reaction. A positive correlation between the @entity0 's age and an intensity of the converse symptoms was found. The Hoigne'a syndrome was a strong @entity4 , and was treated as an @entity1 for all of the @entity0 . The @entity0 were afraid of the next injection and they all refused to give permission for the continuation of such treatment. @entity5 related to @entity3 turned out to be prolonged with a tendency for relapses, and low susceptibility to different methods of treatment. The mechanism of non-allergic acute reaction after @entity9 and ways of its prevention are also discussed.

title: [Acute @entity1 after administration of XXXX as a factor in the occurrence of @entity5 ].

answer: @entity2


abstract: The effect of a @entity1 occurring after injection of @entity6 @entity2 on the occurrence of different @entity5 is a subject of the paper. 31 clinical cases, in which during the @entity2 treatment the said reaction took place, were analysed. It has been found that the most often found consequence of that treatment is conversive @entity7 , and subsequently the @entity8 . On an average an @entity1 occurred after the sixth injection. In 94% of the @entity0 the @entity5 appeared immediately after the described reaction. A positive correlation between the @entity0 's age and an intensity of the converse symptoms was found. The Hoigne'a syndrome was a strong @entity4 , and was treated as an @entity1 for all of the @entity0 . The @entity0 were afraid of the next injection and they all refused to give permission for the continuation of such treatment. @entity5 related to @entity3 turned out to be prolonged with a tendency for relapses, and low susceptibility to different methods of treatment. The mechanism of non-allergic acute reaction after @entity9 and ways of its prevention are also discussed.

title: [Acute @entity1 after administration of @entity2 as a factor in the occurrence of XXXX ].

answer: @entity5


abstract: The effect of a @entity1 occurring after injection of @entity6 @entity2 on the occurrence of different @entity5 is a subject of the paper. 31 clinical cases, in which during the @entity2 treatment the said reaction took place, were analysed. It has been found that the most often found consequence of that treatment is conversive @entity7 , and subsequently the @entity8 . On an average an @entity1 occurred after the sixth injection. In 94% of the @entity0 the @entity5 appeared immediately after the described reaction. A positive correlation between the @entity0 's age and an intensity of the converse symptoms was found. The Hoigne'a syndrome was a strong @entity4 , and was treated as an @entity1 for all of the @entity0 . The @entity0 were afraid of the next injection and they all refused to give permission for the continuation of such treatment. @entity5 related to @entity3 turned out to be prolonged with a tendency for relapses, and low susceptibility to different methods of treatment. The mechanism of non-allergic acute reaction after @entity9 and ways of its prevention are also discussed.

title: [Acute XXXX after administration of @entity2 as a factor in the occurrence of @entity5 ].

answer: @entity1


abstract: The kappa-opioid receptor antagonist @entity6 ( @entity6 ) was recently shown to potentiate certain overt withdrawal signs in @entity3 -dependent @entity0 . The present study sought to further assess this phenomenon by examining the influence of @entity6 treatment upon the conditioned place aversion associated with the @entity4 -precipitated @entity5 . In addition, in vivo microdialysis studies were conducted in @entity3 -dependent @entity0 to determine whether @entity6 treatment can modify withdrawal-induced changes in basal @entity2 (DA) release within the mesolimbic system. @entity0 were pretreated with either saline or a single dose of @entity6 and then received ascending doses of @entity3 for 10 days. A @entity5 was then precipitated by the administration of @entity4 (1 mg/kg SC). In @entity0 which received chronic @entity3 injections, administration of @entity4 produced a characteristic @entity5 and a marked aversion for an environment previously associated with @entity4 -precipitated withdrawal. @entity6 treatment potentiated most overt signs of @entity1 . This treatment also resulted in a greater withdrawal-induced place aversion. @entity3 -dependent @entity0 exhibited a marked reduction in basal mesolimbic DA release. An even greater decrease in basal DA release was observed in @entity6 treated @entity0 . These results suggest that endogenous kappa-systems are important in the modulation of mesolimbic DA release and the accompanying place aversion which occurs during opiate withdrawal.

title: Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic XXXX release.

answer: @entity2


abstract: The pharmacological specificity of alpha-2 adrenoceptor involvement in the modulation of rough-and-tumble play behavior was assessed in juvenile @entity0 . The alpha-2 adrenoceptor antagonists @entity3 and @entity4 both increased the frequency of pinning in individually housed @entity0 that were given a brief opportunity to play. Dorsal contacts, a measure of play solicitation, were not consistently affected by these compounds. Since @entity4 shows little affinity for non-adrenoceptor @entity1 binding sites, it is likely that the facilitation of play following administration of these two compounds is due to blockade of alpha-2 receptors. The effect of @entity4 and @entity3 is unlikely to be an artifact associated with using @entity0 that are reared in isolation, as @entity4 also increased pinning, as well as dorsal contacts, in group-housed @entity0 that were isolated for a short period (4h) before the play session. The alpha-1 adrenoceptor antagonist @entity2 , which also binds to alpha-2B receptors, reduced the frequency of both pinning and dorsal contacts. There was a strong trend for @entity5 , a centrally active alpha-1 agonist, to attenuate the effect of @entity2 on play. While this leaves open the possibility that @entity2 may be reducing play through alpha-1 blockade, antagonist activity at alpha-2B receptors cannot be ruled out. From these data, we conclude that the facilitation of play following @entity3 and @entity4 is likely due to blockade of alpha-2A adrenoceptors. These findings add further support for a specific role of alpha-adrenoceptors in the modulation of playfulness in the juvenile @entity0 .

title: Effects of alpha-2 adrenoceptor antagonists on rough-and-tumble play in juvenile @entity0 : evidence for a site of action independent of non-adrenoceptor XXXX binding sites.

answer: @entity1


abstract: The pharmacological specificity of alpha-2 adrenoceptor involvement in the modulation of rough-and-tumble play behavior was assessed in juvenile @entity0 . The alpha-2 adrenoceptor antagonists @entity3 and @entity4 both increased the frequency of pinning in individually housed @entity0 that were given a brief opportunity to play. Dorsal contacts, a measure of play solicitation, were not consistently affected by these compounds. Since @entity4 shows little affinity for non-adrenoceptor @entity1 binding sites, it is likely that the facilitation of play following administration of these two compounds is due to blockade of alpha-2 receptors. The effect of @entity4 and @entity3 is unlikely to be an artifact associated with using @entity0 that are reared in isolation, as @entity4 also increased pinning, as well as dorsal contacts, in group-housed @entity0 that were isolated for a short period (4h) before the play session. The alpha-1 adrenoceptor antagonist @entity2 , which also binds to alpha-2B receptors, reduced the frequency of both pinning and dorsal contacts. There was a strong trend for @entity5 , a centrally active alpha-1 agonist, to attenuate the effect of @entity2 on play. While this leaves open the possibility that @entity2 may be reducing play through alpha-1 blockade, antagonist activity at alpha-2B receptors cannot be ruled out. From these data, we conclude that the facilitation of play following @entity3 and @entity4 is likely due to blockade of alpha-2A adrenoceptors. These findings add further support for a specific role of alpha-adrenoceptors in the modulation of playfulness in the juvenile @entity0 .

title: Effects of alpha-2 adrenoceptor antagonists on rough-and-tumble play in juvenile XXXX : evidence for a site of action independent of non-adrenoceptor @entity1 binding sites.

answer: @entity0


abstract: A survey of @entity0 attending ten outpatient @entity2 clinics throughout northern Britain was undertaken to identify opportunities for improving the treatment of @entity2 @entity0 . A short data collection form was designed to obtain information at every @entity0 consultation. The @entity0 were found to be a diverse group, many with @entity2 problems. For many @entity0 meaningful diagnoses could not be obtained. The focus of the study was altered to address a selected group of @entity0 : those with @entity2 . This group was selected because it was comparatively easy to define, and previous studies suggested that @entity1 @entity2 might not always be well managed. Many @entity0 were found not to have had adequate trials of potentially effective therapies prior to attendance at the @entity2 clinics. Some of these therapies, such as antidepressants and anticonvulsants, could have been prescribed by general practitioners. However, there were also substantial differences between the clinics in the proportion of @entity0 receiving particular therapies. Finally, although many @entity0 had psychological morbidity few were offered psychological assessment and management. These studies have shown that the @entity2 clinics provide a range of therapies which @entity0 are unlikely to receive elsewhere. But there is scope for improvement in the management of @entity0 in @entity2 clinics and efforts are currently being directed towards this.

title: Entering the loop: assessing the contribution of XXXX clinics in northern Britain.

answer: @entity2