abstract: OBJECTIVE: To describe trajectories of functional decline over 84 months and study associated risk factors among adults initially without limitation who had or were at risk of knee @entity4 . METHODS: We used annual measures of WOMAC physical function over 84 months from the @entity4 Initiative. We included knees with no functional limitation (i.e. WOMAC = 0) at baseline. Knee-based trajectories of functional decline from WOMAC were identified from a group-based trajectory model (PROC TRAJ). RESULTS: We identified five trajectories from 2110 knees (1055 @entity0 , age 61.0    9.3, BMI 27.1    4.4, 52% @entity0 ). Half of the knees (54%) remained free of limitation over 84 months, 26% slowly declined to a WOMAC of 1.5, 9% were limitation free for the first 36 months and declined to a WOMAC of 11.3, 6% rapidly declined over the first 12 months and gradually recovered to a WOMAC of 3.3 and 5% steadily declined to a WOMAC of 13.2. Baseline radiographic disease, @entity2 , @entity1 and @entity3 symptoms at baseline were associated with trajectories of worse functional decline. CONCLUSION: Five per cent of our sample initially without limitation was on a trajectory of progressive functional decline over 84 months later. We found worse disease and health status at baseline to be associated with faster decline over time.

title: Trajectories of functional decline in knee XXXX : the @entity4 Initiative.

answer: @entity4


abstract: OBJECTIVE: To describe trajectories of functional decline over 84 months and study associated risk factors among adults initially without limitation who had or were at risk of knee @entity4 . METHODS: We used annual measures of WOMAC physical function over 84 months from the @entity4 Initiative. We included knees with no functional limitation (i.e. WOMAC = 0) at baseline. Knee-based trajectories of functional decline from WOMAC were identified from a group-based trajectory model (PROC TRAJ). RESULTS: We identified five trajectories from 2110 knees (1055 @entity0 , age 61.0    9.3, BMI 27.1    4.4, 52% @entity0 ). Half of the knees (54%) remained free of limitation over 84 months, 26% slowly declined to a WOMAC of 1.5, 9% were limitation free for the first 36 months and declined to a WOMAC of 11.3, 6% rapidly declined over the first 12 months and gradually recovered to a WOMAC of 3.3 and 5% steadily declined to a WOMAC of 13.2. Baseline radiographic disease, @entity2 , @entity1 and @entity3 symptoms at baseline were associated with trajectories of worse functional decline. CONCLUSION: Five per cent of our sample initially without limitation was on a trajectory of progressive functional decline over 84 months later. We found worse disease and health status at baseline to be associated with faster decline over time.

title: Trajectories of functional decline in knee @entity4 : the XXXX Initiative.

answer: @entity4


abstract: (A) OBJECTIVES: To underline peculiar @entity1 and to propose an epidemiologic studies of urinary stones in West-Africa countries, which are scarce. Only few data are available regarding stone composition in sub-Saharan countries. Recently, a set of 100 stones consecutively removed by surgery in the Department of Urology of the University Hospital of Ouagadougou in Burkina Faso were collected for physical analysis, providing the opportunity to obtain an epidemiological profile of stone composition in this country. (B) METHODS: 100 stones from 64 @entity0 , 22 @entity0 , 10 @entity0 and 4 @entity0 were analysed by morphological examination, infrared spectroscopy and electron microscopy in our laboratory. The results were considered by sex and separately for adults and @entity0 . (C) RESULTS: Among the 100 stones, 65% contained @entity3 as the main component. Interestingly, the second main component was opaline @entity2 (18%). Furthermore, this peculiar compound was identified in any proportion in 48% of the stones. The prevalence was sex and age dependent. Opaline @entity2 was detected as the main component in 42% of the nuclei, underlining its role as one of the main components involved in the initiation of calculi in this country. (D) CONCLUSIONS: For the first time, a dramatically high occurrence of a "scarce" urinary stones' component, namely opaline @entity2 , was reported in a series of consecutive calculi from a single country. We propose that a regular consumption of clay could be the origin of this phenomenon in these populations.

title: High Prevalence of Opaline XXXX in Urinary Stones From Burkina Faso.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is a prototypic @entity1 . Complement component 4 ( @entity4 ) has be proved to play a role in pathogenesis of @entity2 . In the present study, we investigated the effect of @entity4 on T cells differentiation. METHODS: Thirty @entity2 @entity0 were included in this study. CD4+ T cells were isolated from healthy subjects, and dendritic cells (DCs) were isolated from healthy subjects or @entity2 @entity0 . @entity4 was supplemented to co-incubate with T cells and DCs. RESULTS: Serum @entity4 concentration was positively correlated with regulatory T cell (Treg) percentage (R(2)  =  0.5907, p  <  0.001) and @entity3 concentration (R(2)  =  0.5641, p  <  0.001) in @entity2 @entity0 . Different concentrations of @entity4 had no effect on T cells differentiation. Co-incubated T cells with DCs and @entity4 for 7  days, the Treg percentage and @entity3 concentration were significantly elevated. In addition, pre-treated DCs (from healthy subjects or @entity2 @entity0 ) with @entity4 and then co-incubated with T cells, the increases of Treg percentage and @entity3 concentration were also observed. CONCLUSION: @entity4 takes part in T cells differentiation to Treg cells via DCs.

title: Complement C4 induces regulatory T cells differentiation through XXXX .

answer: @entity2


abstract: AIMS: Although coronary artery @entity2 (CAC) has been established as a robust tool for predicting total mortality during intermediate follow-up, less is known about the long-term predictive value of CAC. METHODS AND RESULTS: This study included 13 092 asymptomatic @entity0 without known @entity1 who underwent a clinically indicated CAC scan. CAC was categorized as an Agatson score of 0, 1-99, 100-399, and >= 400. We used multivariable Cox proportional hazards to calculate adjusted hazard ratios (HRs) for mortality stratified by age (younger, intermediate, or older) and gender. The mean age of @entity0 was 58    11 years and 67% were @entity0 . During a median follow-up of 11.0    3.2 years, there were 522 deaths (4.0%). Compared with CAC = 0, increasing CAC was associated with higher mortality rate: 1-99 [HR: 1.5, 95% confidence interval (95% CI): 1.1-2.1]; 100-399 (HR: 1.8, 95% CI: 1.3-2.5); >= 400 (HR: 2.6, 95% CI: 1.9-3.6). Relative risk according to CAC category did not differ between genders. The strongest associations between CAC and mortality were observed for young and intermediate age @entity0 . Nonetheless, the mortality rate of the older @entity0 with CAC = 0 was far lower than that of the general US population. CAC was more predictive of long-term (15 years) than intermediate-term (5 years) mortality for @entity0 [receiver operator characteristics (ROC): 0.723 vs. 0.702] and @entity0 (ROC: 0.69 vs. 0.65). CONCLUSION: CAC is strongly associated with the long-term risk of mortality in young- and middle-aged @entity0 and @entity0 . In older @entity0 , the long-term risk stratification of CAC is lower, due principally to increased mortality rate in @entity0 with low @entity2 scores; however, even in the older @entity0 , those with absent or low CAC are at a significantly lower risk of mortality compared with the general population.

title: All-cause mortality by age and gender based on coronary artery XXXX scores.

answer: @entity2


abstract: PURPOSE: The @entity4 / @entity6 ( @entity8 /P) ratio was shown to vary between healthy bones and bones with @entity5 . The relation of the @entity8 /P ratio to @entity1 remains under investigation. To study this relation and determine if the ratio can be used to predict @entity3 , a non-invasive 3D imaging technique is required. The first aim of this study was to test the effectiveness of a computed-tomography dual-energy analysis (CT-DEA) technique developed to assess the @entity8 /P ratio in bone apatite (collagen-free bone) in identifying differences between healthy and @entity0 -mediated @entity7 (IMO) bones. The second aim was to extend the above technique for its application to a more complex structure, intact bone, that could potentially lead to clinical use. METHODS: For the first aim, healthy and IMO @entity2 cortical bone apatite samples were assessed. For the second aim, some changes were made to the technique, which was applied to healthy and IMO intact bone samples. RESULTS: Statistically significant differences between healthy and IMO bone apatite were found for the bulk @entity8 /P ratio, low @entity8 /P ratio proportion and interconnected low @entity8 /P ratio proportion. For the intact bone samples, the bulk @entity8 /P ratio was found to be significantly different between healthy and IMO. CONCLUSIONS: Results show that the CT-DEA technique can be used to identify differences in the @entity8 /P ratio between healthy and @entity7 , in both bone apatite and intact bone. With quantitative imaging becoming an increasingly important advancement in medical imaging, CT-DEA for bone decomposition could potentially have several applications.

title: Evaluation of the 3D spatial distribution of the @entity4 / XXXX ratio in bone using computed-tomography dual-energy analysis.

answer: @entity6


abstract: PURPOSE: The @entity4 / @entity6 ( @entity8 /P) ratio was shown to vary between healthy bones and bones with @entity5 . The relation of the @entity8 /P ratio to @entity1 remains under investigation. To study this relation and determine if the ratio can be used to predict @entity3 , a non-invasive 3D imaging technique is required. The first aim of this study was to test the effectiveness of a computed-tomography dual-energy analysis (CT-DEA) technique developed to assess the @entity8 /P ratio in bone apatite (collagen-free bone) in identifying differences between healthy and @entity0 -mediated @entity7 (IMO) bones. The second aim was to extend the above technique for its application to a more complex structure, intact bone, that could potentially lead to clinical use. METHODS: For the first aim, healthy and IMO @entity2 cortical bone apatite samples were assessed. For the second aim, some changes were made to the technique, which was applied to healthy and IMO intact bone samples. RESULTS: Statistically significant differences between healthy and IMO bone apatite were found for the bulk @entity8 /P ratio, low @entity8 /P ratio proportion and interconnected low @entity8 /P ratio proportion. For the intact bone samples, the bulk @entity8 /P ratio was found to be significantly different between healthy and IMO. CONCLUSIONS: Results show that the CT-DEA technique can be used to identify differences in the @entity8 /P ratio between healthy and @entity7 , in both bone apatite and intact bone. With quantitative imaging becoming an increasingly important advancement in medical imaging, CT-DEA for bone decomposition could potentially have several applications.

title: Evaluation of the 3D spatial distribution of the XXXX / @entity6 ratio in bone using computed-tomography dual-energy analysis.

answer: @entity4


abstract: OBJECTIVE: To find bullying victimisation as a predictor of physical and @entity2 among school-going @entity0 with @entity1 . METHODS: The co-relational cross-sectional study was conducted in Gujrat district of Pakistan's Punjab province from August 2014 to January 2015, and comprised adolescents with @entity1 . The subjects were selected through multi-stage stratified proportionate sampling from the local schools. Two standardised instruments were administered to assess the relationship between bullying and health problems. Multidimensional Peer Victimisation Scale was used for measuring bullying behaviour, while the Health Questionnaire was used to assess physical and @entity2 . Both scales were translated into Urdu using lexicon equivalence method of translation. RESULTS: Of the 286 subjects, 183(64%) were @entity0 . A significant positive relationship was found between the four components of bullying and health problems (p<0.05 each). @entity0 experienced more physical victimisation than @entity0 (p<0.05), but there was no significant difference between @entity0 and @entity0 in social manipulation (p>0.05). CONCLUSIONS: @entity0 with @entity1 experienced bullying just like those without such an impairment. Bullying needs to be considered a significant public health issue and should be dealt with effectively.

title: Bullying victimization: A risk factor of health problems among adolescents with XXXX .

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: The perception of threat and associated feelings of @entity1 typically prompt @entity0 to seek safety; reassurance seeking is an interpersonal strategy almost universally used to reduce the immediate perception of risk. @entity4 ( @entity4 ) is considered to be particularly prominent and unequivocally counter-productive in @entity0 suffering from @entity1 in general and @entity2 in particular, producing short term relief but a longer term return and worsening of the original @entity1 . We evaluated the extent and specificity of the effects of @entity4 in @entity2 and mechanisms involved in both @entity1 relief and the hypothesized later return of @entity1 .. METHOD: Self rated effects of reassurance seeking were investigated in 153 individuals with @entity2 , 50 with @entity3 , and 52 healthy controls, evaluating reactions to the provision and non-provision of reassurance. RESULTS: Reassurance is associated with short term relief then longer term return of both discomfort and the urge to seek further reassurance in both anxious groups; healthy controls do not experience significant resurgence. Greater return of @entity1 and urge to seek more reassurance were associated with higher levels of overall reassurance seeking.. LIMITATIONS: The findings were based on retrospective self-report of naturally occurring episodes of @entity4 ; prospective studies and induced behaviours are now needed. CONCLUSIONS: Not only is reassurance a quick fix for @entity0 experiencing @entity2 , but in the absence of treatment the only fix! The findings explain why reassurance seeking continues despite advice that it will worsen @entity1 problems. Such advice is potentially harmful to @entity0 and their loved ones..

title: Reassuringly calm? Self-reported patterns of responses to reassurance seeking in XXXX .

answer: @entity2


abstract: The central nervous system has limited capacity for regeneration after @entity1 . Transplantation of neural stem/progenitor cells (NPCs) has been proposed as a potential therapeutic approach while @entity6 ( @entity6 ) has neuroprotective properties following various experimental insults to the nervous system. We have previously shown that NPCs transduced with a lentiviral vector for @entity6 overexpression have an enhanced ability to give rise to neurons in vitro but also in vivo, upon transplantation in a @entity0 model of @entity3 . Here we studied the regenerative potential of NPCs, @entity6 -transduced or not, in a @entity0 model of @entity2 . NPC transplantation, with or without @entity6 transduction, rescued the injury-induced @entity4 as revealed in the Morris Water Maze. Moreover, it had beneficial effects on the host tissue by reducing astroglial activation and microglial/macrophage accumulation while enhancing generation of endogenous oligodendrocyte precursor cells. One or two months after transplantation the grafted NPCs had migrated towards the lesion site and in the neighboring myelin-rich regions. Transplanted cells differentiated toward the oligodendroglial, but not the neuronal or astrocytic lineages, expressing the early and late oligodendrocyte markers @entity5 , @entity7 , and @entity8 . The newly generated oligodendrocytes reached maturity and formed myelin internodes. Our current and previous observations illustrate the high plasticity of transplanted NPCs which can acquire injury-dependent phenotypes within the host CNS, supporting the fact that reciprocal interactions between transplanted cells and the host tissue are an important factor to be considered when designing prospective cell-based therapies for CNS degenerative conditions. GLIA 2016;64:763-779.

title: Neural stem/progenitor cells differentiate into oligodendrocytes, reduce inflammation, and ameliorate @entity4 after transplantation in a @entity0 model of XXXX .

answer: @entity2


abstract: The central nervous system has limited capacity for regeneration after @entity1 . Transplantation of neural stem/progenitor cells (NPCs) has been proposed as a potential therapeutic approach while @entity6 ( @entity6 ) has neuroprotective properties following various experimental insults to the nervous system. We have previously shown that NPCs transduced with a lentiviral vector for @entity6 overexpression have an enhanced ability to give rise to neurons in vitro but also in vivo, upon transplantation in a @entity0 model of @entity3 . Here we studied the regenerative potential of NPCs, @entity6 -transduced or not, in a @entity0 model of @entity2 . NPC transplantation, with or without @entity6 transduction, rescued the injury-induced @entity4 as revealed in the Morris Water Maze. Moreover, it had beneficial effects on the host tissue by reducing astroglial activation and microglial/macrophage accumulation while enhancing generation of endogenous oligodendrocyte precursor cells. One or two months after transplantation the grafted NPCs had migrated towards the lesion site and in the neighboring myelin-rich regions. Transplanted cells differentiated toward the oligodendroglial, but not the neuronal or astrocytic lineages, expressing the early and late oligodendrocyte markers @entity5 , @entity7 , and @entity8 . The newly generated oligodendrocytes reached maturity and formed myelin internodes. Our current and previous observations illustrate the high plasticity of transplanted NPCs which can acquire injury-dependent phenotypes within the host CNS, supporting the fact that reciprocal interactions between transplanted cells and the host tissue are an important factor to be considered when designing prospective cell-based therapies for CNS degenerative conditions. GLIA 2016;64:763-779.

title: Neural stem/progenitor cells differentiate into oligodendrocytes, reduce inflammation, and ameliorate XXXX after transplantation in a @entity0 model of @entity2 .

answer: @entity4


abstract: The central nervous system has limited capacity for regeneration after @entity1 . Transplantation of neural stem/progenitor cells (NPCs) has been proposed as a potential therapeutic approach while @entity6 ( @entity6 ) has neuroprotective properties following various experimental insults to the nervous system. We have previously shown that NPCs transduced with a lentiviral vector for @entity6 overexpression have an enhanced ability to give rise to neurons in vitro but also in vivo, upon transplantation in a @entity0 model of @entity3 . Here we studied the regenerative potential of NPCs, @entity6 -transduced or not, in a @entity0 model of @entity2 . NPC transplantation, with or without @entity6 transduction, rescued the injury-induced @entity4 as revealed in the Morris Water Maze. Moreover, it had beneficial effects on the host tissue by reducing astroglial activation and microglial/macrophage accumulation while enhancing generation of endogenous oligodendrocyte precursor cells. One or two months after transplantation the grafted NPCs had migrated towards the lesion site and in the neighboring myelin-rich regions. Transplanted cells differentiated toward the oligodendroglial, but not the neuronal or astrocytic lineages, expressing the early and late oligodendrocyte markers @entity5 , @entity7 , and @entity8 . The newly generated oligodendrocytes reached maturity and formed myelin internodes. Our current and previous observations illustrate the high plasticity of transplanted NPCs which can acquire injury-dependent phenotypes within the host CNS, supporting the fact that reciprocal interactions between transplanted cells and the host tissue are an important factor to be considered when designing prospective cell-based therapies for CNS degenerative conditions. GLIA 2016;64:763-779.

title: Neural stem/progenitor cells differentiate into oligodendrocytes, reduce inflammation, and ameliorate @entity4 after transplantation in a XXXX model of @entity2 .

answer: @entity0


abstract: UNASSIGNED: The objective of this study was to evaluate the effect of increasing the supply of protein with different degradation rates on the performance and metabolism of growing Nellore @entity0 reared on Brachiaria brizantha cv. Marandu pasture during the transition period from the dry to rainy season. The experiment was installed on an area of 34  ha, divided into 12 paddocks with an average area of 2.85  ha. In the performance evaluation were utilized 72 recently weaned, non-castrated Nellore @entity0 with an initial body weight (BW) of 199  kg (SEM   =   16). The following supplements were used: energy protein supplement containing 25  % @entity1 ( @entity1 ) (C-25) and energy protein supplements containing 40  % @entity1 with one third highly degradable @entity1 and two thirds poorly degradable @entity1 (40-1/3NPN), one half highly degradable @entity1 and one half poorly degradable @entity1 (40-1/2NPN), and two thirds highly degradable @entity1 and one third poorly degradable @entity1 (40-2/3NPN). Higher protein degradation rates reduced supplement intake (P   <   0.01). In the first period, animals consuming supplement 40-1/3NPN exhibited higher average daily gain (ADG) (0.30  kg/day), similar to that of animals receiving supplement 40-1/2NPN (P   =   0.04). In the second period, supplement 40-2/3NPN resulted in lower ADG (0.19  kg/day less than the other supplements). There was no effect of supplement on animal performance in the third period (P   >   0.10), when ADG was 0.56  kg/day. In conclusion, the response to supplementation is associated with interactions with characteristics of the forage canopy. Supplementation with a true protein source will be beneficial only during the early stage of the dry-rainy season transition period.

title: Effect of supplementation of beef XXXX with different protein levels and degradation rates during transition from the dry to rainy season.

answer: @entity0


abstract: OBJECTIVE: To explore the outcomes of multiple derotation plus costotransversectomy for @entity0 with severe and @entity7 . METHODS: Clinical analyses were conducted for the clinical data of operative duration, @entity2 volume and SRS-22 scale. Radiographic data included Cobb angle of coronal curves, apical vertebral translation, coronal balance and sagittal balance. All measurements were taken pre-operation, post-operation and during the final follow-up period. RESULTS: The mean follow-up period was 4.1    0.7 (3-5.5) years, mean operative duration 33    8.4 min and mean @entity2 volume 2303.5    9.0 ml. Preoperative major curves ranged from 65   to 110   Cobb angle. Coronal plane correction of major curve from 10   to 41   Cobb angle (mean 30.8    9.8  ). And there was a mean loss of correction of 3.6% during the final follow-up. The magnitudes of @entity3 and @entity5 were 31.1    12.4  , 45.5    10.5   pre-operation, 25.6    5.5  , 33.43    5.45   post-operation and 28.6    6.1  , 35.26    4.2   during the final follow-up. The apical vertebral translation of major curve was corrected by 73.2%. The coronal imbalance, sagittal imbalance and apical vertebral translation indifferently was 3.2    1.1, 2.3    1.1, 6.35    1.65 cm pre-operation, 0.9    1.0, 0.4    0.5, 2.4    1.2 cm post-operation and 1.2    1.1, 0.6    0.5, 2.6    1.4 cm during the final follow-up. Incomplete @entity4 occurred in one case and superficial dermatoedge @entity1 in another recovered within 2 weeks. Neither malposition of pedicle screw nor complication of instrumentation was found. Excellent outcomes were obtained according to SRS-22 score. CONCLUSION: For @entity0 with severe and @entity7 , the technique of multi-rod-derotation and rib resection may achieve a good correction of @entity6 without serious complications and avoid a resection of vertebral column.

title: [Multiple derotation plus costotransversectomy for severe and XXXX ].

answer: @entity7


abstract: 1. The @entity0 -dependent @entity2 dehydrogenase of @entity1 undergoes slow reversible structural transitions, with half-times in the order of a few minutes, between active and inactive states. The inactive state of the enzyme, which predominates at pH values below 7.0, has an intrinsic @entity3 fluorescence 25% lower than that of the active state, which predominates at pH values above 7.6. The inactive state can be activated either by an increase in pH or by addition of activators such as succinate. 2. The kinetics of the slow transitions that follow activating and inactivating rapid changes in conditions have been monitored by measurements of protein fluorescence. The results show that the slow reversible conformational change detected by the change in fluorescence is the rate-limiting process for enzyme activation and inactivation. 3. In both directions this conformational change follows apparent first-order kinetics and the rate constant is independent of protein concentration. These kinetics and published measurements of molecular weight are indicative of an isomerization process. 4. In both directions the changes show a large energy of activation and a large positive entropy of activation, consistent with a considerable disturbance of conformation in the transition state. 5. Comparisons of the fluorescence emission spectra of the active and inactive states indicate that the difference in fluorescence is produced by quenching, possibly intramolecular, in the inactive conformation. @entity4 ions cause similar quenching. 6. In some mutationally altered forms of the enzyme comparable but modified conformational changes can be followed by protein fluorescence.

title: Slow conformational changes of a @entity1 XXXX dehydrogenase studied by protein fluorescence.

answer: @entity2


abstract: 1. The @entity0 -dependent @entity2 dehydrogenase of @entity1 undergoes slow reversible structural transitions, with half-times in the order of a few minutes, between active and inactive states. The inactive state of the enzyme, which predominates at pH values below 7.0, has an intrinsic @entity3 fluorescence 25% lower than that of the active state, which predominates at pH values above 7.6. The inactive state can be activated either by an increase in pH or by addition of activators such as succinate. 2. The kinetics of the slow transitions that follow activating and inactivating rapid changes in conditions have been monitored by measurements of protein fluorescence. The results show that the slow reversible conformational change detected by the change in fluorescence is the rate-limiting process for enzyme activation and inactivation. 3. In both directions this conformational change follows apparent first-order kinetics and the rate constant is independent of protein concentration. These kinetics and published measurements of molecular weight are indicative of an isomerization process. 4. In both directions the changes show a large energy of activation and a large positive entropy of activation, consistent with a considerable disturbance of conformation in the transition state. 5. Comparisons of the fluorescence emission spectra of the active and inactive states indicate that the difference in fluorescence is produced by quenching, possibly intramolecular, in the inactive conformation. @entity4 ions cause similar quenching. 6. In some mutationally altered forms of the enzyme comparable but modified conformational changes can be followed by protein fluorescence.

title: Slow conformational changes of a XXXX @entity2 dehydrogenase studied by protein fluorescence.

answer: @entity1


abstract: OBJECTIVE: To compare the levels of @entity1 ( @entity2 ), both oxidized and reduced forms in @entity0 with and without @entity3 in gingival crevicular fluid (GCF). MATERIALS AND METHODS: Twenty GCF samples from maxillary quadrants were collected using capillary micropipettes from the @entity3 @entity0 (test group) at baseline before treatment, at 1-month, 3 months, and 6 months after scaling and root planing and samples from 20 @entity0 without @entity3 (control group) from maxillary quadrants were also collected. @entity2 , @entity4 ( @entity4 ) levels and @entity2 : @entity4 ratios were determined using the spectrophotometric method. STATISTICAL ANALYSIS: Results were concluded for the test over control groups using paired Student's t-test. RESULTS: Lower concentrations of @entity2 (P < 0.001) and @entity4 (P < 0.001) were detected in GCF in @entity0 with @entity3 (test group) than @entity0 without @entity3 (control group) at baseline. Treatment had a significant effect in improving the @entity2 and reducing @entity4 levels postscaling and root planing at 1-month and 3 months but not significant effect at 6 months. Scaling and root planing increased the @entity2 : @entity4 ratio (P < 0.001) in the test group as compared to the control group (P < 0.001). CONCLUSIONS: The concentrations of @entity2 within GCF are reduced in @entity3 @entity0 . Scaling and root planing (nonsurgical therapy) restores @entity2 concentration in GCF post 1-month and 3 months along with redox balance ( @entity2 : @entity4 ratio), but at 6 months the balance is not maintained. Adjunctive use of micronutritional supplements to boost antioxidant concentration in tissues by preserving @entity2 or by elevating its level at the inflamed sites is recommended, as nonsurgical periodontal therapy alone is not able to maintain redox balance for longer duration.

title: Evaluation of non-surgical therapy on @entity1 levels in XXXX .

answer: @entity3


abstract: OBJECTIVE: To compare the levels of @entity1 ( @entity2 ), both oxidized and reduced forms in @entity0 with and without @entity3 in gingival crevicular fluid (GCF). MATERIALS AND METHODS: Twenty GCF samples from maxillary quadrants were collected using capillary micropipettes from the @entity3 @entity0 (test group) at baseline before treatment, at 1-month, 3 months, and 6 months after scaling and root planing and samples from 20 @entity0 without @entity3 (control group) from maxillary quadrants were also collected. @entity2 , @entity4 ( @entity4 ) levels and @entity2 : @entity4 ratios were determined using the spectrophotometric method. STATISTICAL ANALYSIS: Results were concluded for the test over control groups using paired Student's t-test. RESULTS: Lower concentrations of @entity2 (P < 0.001) and @entity4 (P < 0.001) were detected in GCF in @entity0 with @entity3 (test group) than @entity0 without @entity3 (control group) at baseline. Treatment had a significant effect in improving the @entity2 and reducing @entity4 levels postscaling and root planing at 1-month and 3 months but not significant effect at 6 months. Scaling and root planing increased the @entity2 : @entity4 ratio (P < 0.001) in the test group as compared to the control group (P < 0.001). CONCLUSIONS: The concentrations of @entity2 within GCF are reduced in @entity3 @entity0 . Scaling and root planing (nonsurgical therapy) restores @entity2 concentration in GCF post 1-month and 3 months along with redox balance ( @entity2 : @entity4 ratio), but at 6 months the balance is not maintained. Adjunctive use of micronutritional supplements to boost antioxidant concentration in tissues by preserving @entity2 or by elevating its level at the inflamed sites is recommended, as nonsurgical periodontal therapy alone is not able to maintain redox balance for longer duration.

title: Evaluation of non-surgical therapy on XXXX levels in @entity3 .

answer: @entity1


abstract: AIM: Global-scale studies are required to identify broad-scale patterns in the distributions of species, to evaluate the processes that determine diversity and to determine how similar or different these patterns and processes are among different groups of freshwater species. Broad-scale patterns of spatial variation in species distribution are central to many fundamental questions in macroecology and conservation biology. We aimed to evaluate how congruent three commonly used metrics of diversity were among taxa for six groups of freshwater species. LOCATION: Global. METHODS: We compiled geographical range data on 7083 freshwater species of mammals, amphibians, reptiles, fishes, crabs and crayfish to evaluate how species @entity0 , @entity0 of threatened species and @entity1 are distributed across freshwater ecosystems. We evaluated how congruent these measures of diversity were among taxa at a global level for a grid cell size of just under 1  . RESULTS: We showed that although the risk of extinction faced by freshwater decapods is quite similar to that of freshwater vertebrates, there is a distinct lack of spatial congruence in geographical range between different taxonomic groups at this spatial scale, and a lack of congruence among three commonly used metrics of biodiversity. The risk of extinction for freshwater species was consistently higher than for their terrestrial counterparts. MAIN CONCLUSIONS: We demonstrate that broad-scale patterns of species @entity0 , threatened-species @entity0 and @entity1 lack congruence among the six freshwater taxonomic groups examined. Invertebrate species are seldom taken into account in conservation planning. Our study suggests that both the metric of biodiversity and the identity of the taxa on which conservation decisions are based require careful consideration. As geographical range information becomes available for further sets of species, further testing will be warranted into the extent to which geographical variation in the @entity0 of these six freshwater groups reflects broader patterns of biodiversity in fresh water.

title: Global patterns of freshwater species diversity, threat and XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a chemosensitive disease with high response rates to @entity6 -based combination chemotherapy in locally advanced or advanced disease. However, de novo or emergence of @entity5 -resistance limits the duration of response, @entity0 are frequently ineligible for @entity5 , and therapies tested thus far have minimal activity as second-line therapy. The first wave of clinical trials of novel agents and targeted therapy have modestly advanced the field and laid the foundations for future studies. These trials include the deployment of monoclonal antibodies and @entity7 kinase inhibitors that target mediators of angiogenesis and growth receptors. Novel cytotoxic agents have also been tested as single-agents in the second-line setting and together with the first-line combination of @entity2 with @entity5 . To date, these novel agents have yet to demonstrate the ability to substantially improve the overall survival of @entity0 with @entity3 . Comparative trials of chemotherapy with or without a novel agent are ongoing and have the potential to improve upon current standard therapy. Moreover, state-of-the-art technologies have been developed that will likely identify the molecular alterations which drive both @entity4 and @entity6 -resistance and in turn provide opportunities for drug development. The latter includes an interrogation of microRNAs and the integrated study of genetic mutations in extreme phenotypes of the disease. In essence, this ongoing work paired with physician and @entity0 commitments to clinical trial participation will ultimately lead to advances in the care of @entity0 with @entity1 .

title: Update in XXXX : Novel Agents and Targeted Therapy.

answer: @entity4


abstract: OBJECTIVE: To compare the mean root mean square (RMS) of total higher order aberrations (HOAs), @entity1 in individuals with @entity3 , @entity7 and @entity2 . METHODS: This prospective analytical study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from Jan 2014 to Dec 2014. Two hundred eyes of 121 @entity0 with age ranging from 18-40 years were included in the study. @entity0 were divided into 4 group namely Low @entity3 , @entity3 , @entity2 and @entity7 on the basis of @entity6 . Included were the @entity0 who had @entity6 more than    0.5D and best corrected visual acuity (BCVA) of 0.00 or better. @entity0 who had history of surgery and / or @entity5 were excluded from the study. Visual acuity (VA), @entity8 ( @entity8 ) of @entity1 and spherical aberrations were evaluated. HOAs were measured with aberrometer (Wavelight analyzer version 1073) at 6 mm pupil size. RESULTS: Age of the @entity0 ranged from 18 years to 40 years with mean age of 29.10  10.6 years. Seventy one (35.5%) were males and 129 (64.5%) were female. Mean RMS value of HOAs, @entity1 was calculated in all four groups. RMS of total HOAs and spherical aberrations in @entity7 was 0.96  0.96 and 0.30  0.42 respectively and it was higher than other three groups. CONCLUSIONS: In overall comparison the mean RMS of total HOAs and spherical aberrations was significantly increased in @entity7 group and there was a statistically significant negative correlation of @entity8 of @entity7 with @entity4 .

title: Comparison of higher order aberrations in @entity0 with various XXXX .

answer: @entity6


abstract: OBJECTIVE: To compare the mean root mean square (RMS) of total higher order aberrations (HOAs), @entity1 in individuals with @entity3 , @entity7 and @entity2 . METHODS: This prospective analytical study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from Jan 2014 to Dec 2014. Two hundred eyes of 121 @entity0 with age ranging from 18-40 years were included in the study. @entity0 were divided into 4 group namely Low @entity3 , @entity3 , @entity2 and @entity7 on the basis of @entity6 . Included were the @entity0 who had @entity6 more than    0.5D and best corrected visual acuity (BCVA) of 0.00 or better. @entity0 who had history of surgery and / or @entity5 were excluded from the study. Visual acuity (VA), @entity8 ( @entity8 ) of @entity1 and spherical aberrations were evaluated. HOAs were measured with aberrometer (Wavelight analyzer version 1073) at 6 mm pupil size. RESULTS: Age of the @entity0 ranged from 18 years to 40 years with mean age of 29.10  10.6 years. Seventy one (35.5%) were males and 129 (64.5%) were female. Mean RMS value of HOAs, @entity1 was calculated in all four groups. RMS of total HOAs and spherical aberrations in @entity7 was 0.96  0.96 and 0.30  0.42 respectively and it was higher than other three groups. CONCLUSIONS: In overall comparison the mean RMS of total HOAs and spherical aberrations was significantly increased in @entity7 group and there was a statistically significant negative correlation of @entity8 of @entity7 with @entity4 .

title: Comparison of higher order aberrations in XXXX with various @entity6 .

answer: @entity0


abstract: OBJECTIVE: To report our 10-year diagnosis and treatment experience of acute urogenital and genitalia tract @entity2 and outline the management of the @entity2 . METHODS: We reviewed the diagnoses and treatments of 208 cases of acute kidney, ureter, bladder, urethra, or @entity10 in our department between March 2002 and March 2012. The @entity0 data including general information, injury position and mechanism, diagnosis and treatment, the follow-up information was analyzed and summarized. RESULTS: Of 62 @entity0 with @entity1 examined by ultrasound and computed tomography (CT) examination, 45 were treated conservatively, 9 with superselective @entity6 , and 8 with nephrectomy. Intravenous pyelogram (IVP) was conducted in two @entity0 with @entity8 , one was treated with cystoscopic ureteral catheterization and the other with ureteric reimplantation. @entity7 (6 @entity0 ) confirmed with a waterflood susceptibility test combined with CT scans underwent laparotomy and the bladder suturing was done. Of 92 @entity0 with @entity2 , 6 were treated with a nonoperative approach (indwelling catheter), 18 with urethral realignment, 35 with cystoscopic urethral realignment, 29 with end-to-end anastomotic urethroplasty, and 4 with urethral repairmen. Of the 24 cases with @entity3 , 1 underwent conservative treatment, 8 were treated with debridement and suture ligation, and 15 were managed with suture repair of the penis white membrane. Of the 24 cases with @entity3 , 1 underwent conservative treatment, 8 were treated with debridement and suture ligation, and 15 were managed with suture repair of the penis white membrane. During the follow-up period, 62 @entity0 with @entity1 had normal renal function. Neither of the two @entity0 with @entity8 developed @entity9 . Twenty-nine @entity0 with @entity2 suffered from urethral structure. All @entity0 with @entity2 recovered. CONCLUSIONS: Urethra and @entity1 are the most common acute urogenital system @entity2 . Superselective @entity6 can effectively cease @entity4 and maximally protect renal function and ureterorenoscopic realignment is an easily operative and minimally invasive technique in the treatment of @entity2 . As diagnosis and treatment techniques continue to evolve, minimally invasive procedures should be widely used in acute @entity5 .

title: Diagnosis and treatment of acute urogenital and genitalia tract XXXX : 10-year clinical experience.

answer: @entity2


abstract: We performed a retrospective cohort study to increase awareness in orthopaedic community of this rare but interesting disease which is often misdiagnosed as meniscal pathology and to analyze present results of arthroscopic resection in seven @entity0 . we retrospectively reviewed records from 2008-2012 and identified 7 @entity0 with symptomatic Hoffa's fat pad impingement. The diagnosis was made by clinical exam, MRI imaging and verified arthroscopically. Of the 7 @entity0 2 were excluded due to receiving open resection. The remaining five underwent arthroscopic resection. Lysholm and American knee society scores were obtained pre and post operative and at final follow up. There was a significant improvement in their symptoms and function after the surgery at an average follow-up of 14 months. The one poor result was because of paresthesia over the distribution of the infrapatellar branch of the saphenous nerve after open resection. @entity1 like of the fat pad should be treated by arthroscopic resection because of less residual @entity2 was found using arthroscopy. In case of high volume of @entity1 only open excision can provide complete excision.

title: XXXX like: results of the arthroscopic resection.

answer: @entity1


abstract: INTRODUCTION: Percutaneous transvenous mitral commissurotomy (PTMC) is a safe and effective procedure for relief of severe @entity2 . PTMC is being done widely and many transseptal procedures requiring large diameter catheters, sheaths are becoming popular. The knowledge of iatrogenic @entity1 (iASD) is vital. This study assessed the use of real-time 3D echocardiography (RT3DE) and incidence of iASD in a cohort of @entity0 undergoing transseptal catheterization during PTMC. METHODS: One hundred ten @entity0 underwent PTMC. The reliability and accuracy of RT3DE for iASD detection was determined, RT3DE was compared with 2D echocardiography (2DE) for iASD occurrence, influencing variables analyzed and followed up for 1 year. RESULTS: RT3DE is more reliable and accurate for the study of iASD than 2DE. Color RT3DE detected iASD in 94 (85.5%), with 2DE iASD was detected in 74 (67.3%) (P < .0001).On follow up 85% had iASD post procedure, 56% at 6 months, 19% at 1 year follow up. The mean iASD diameter was 5.41    3.12 mm and area 6.57    3.81 mm(2). iASD correlated with @entity0 height, Wilkins score, pre-PTMC LA 'v', and post-PTMC LVEDP. CONCLUSION: RT3DE imaging is superior in accuracy to traditional 2DE techniques. All the modes of RT3DE are useful in the assessment of iASD. iASD measured by RT3DE correlates with several @entity0 , procedural and echocardiographic variables.

title: Real Time 3D Echocardiographic Evaluation of Iatrogenic XXXX After Percutaneous Transvenous Mitral Commissurotomy.

answer: @entity1


abstract: BACKGROUND: Whole slide images (WSIs) involve digitally capturing glass slides for microscopic computer-based viewing and these are amenable to quantitative image analysis. @entity2 ( @entity2 ) brushing can show morphologic features that are categorized as indeterminate for @entity0 . The study aims to evaluate quantitative morphologic features of atypical categories of @entity2 brushing by WSI analysis for the identification of criteria predictive of @entity0 . MATERIALS AND METHODS: Over a 3-year period, @entity2 brush specimens with indeterminate diagnostic categorization (atypical to suspicious) were subjected to WSI analysis. Ten well-visualized groups with morphologic atypical features were selected per case and had the quantitative analysis performed for group area, individual nuclear area, the number of nuclei per group, N: C ratio and nuclear size differential. RESULTS: There were 28 cases identified with 17 atypical and 11 suspicious. The average nuclear area was 63.7   m(2) for atypical and 80.1   m(2) for suspicious (+difference 16.4   m(2); P = 0.002). The nuclear size differential was 69.7   m(2) for atypical and 88.4   m(2) for suspicious (+difference 18.8   m(2); P = 0.009). An average nuclear area >70   m(2) had a 3.2 risk ratio for suspicious categorization. CONCLUSION: The quantitative criteria findings as measured by image analysis on WSI showed that cases categorized as suspicious had more nuclear size pleomorphism (+18.8   m(2)) and larger nuclei (+16.4   m(2)) than those categorized as atypical. WSI with morphologic image analysis can demonstrate quantitative statistically significant differences between atypical and suspicious @entity2 brushings and provide objective criteria that support the diagnosis of @entity1 .

title: Whole slide image with image analysis of atypical bile duct brushing: Quantitative features predictive of XXXX .

answer: @entity0


abstract: Reports on adverse reactions to @entity10 today are common in Sweden and constitute 10 to 12 percent of all incoming reports. We present an analysis of 921 reports of adverse reactions received by the Swedish @entity3 Committee during the period 1966--1976. The two largest groups consist of reports of @entity5 (43 percent) and @entity2 (42 percent). The remaining reports fall into any of four smaller groups, chronic pulmonary reactions, @entity7 , @entity9 or @entity1 . Acute @entity2 in all aspects are very similar and carry the characteristics of an acute @entity2 reaction. The increasing number of reports--even in relation to sales figures--would be best explained by a continuous sensitization. @entity8 ( @entity6 ) afflict older @entity0 , often after prolonged treatment with relatively small doses. We suggest that these reactions are elicited by a toxic mechanism. Seventy-one percent of all reactions were severe enough to cause the @entity0 's hospitalization; only 1 percent was fatal. The risk of an adverse reaction varies with sex and age, increases with age and is higher in @entity0 than in @entity0 . The time has come for a re-evaluation of @entity10 and its role in the treatment of @entity4 .

title: Adverse reactions to XXXX . Analysis of 921 reports.

answer: @entity10


abstract: UNASSIGNED: Although Sistrunk operation is the standard method to treat @entity2 , the reported recurrence rates after a "classic" or "modified" Sistrunk procedure still varied from 0 to 15.8  %, indicating the existence of some technical uncertainties. While simple cystectomy has been recognized as the most important prognostic factor predicting @entity2 recurrence, whether other clinico-pathological parameters also affect disease recurrence has not been well studied. We retrospectively reviewed the medical records of all @entity0 who underwent @entity2 surgery between June 1998 and June 2014 at our institution. Among the 180 primary @entity0 , 160 @entity0 received a "conservative" Sistrunk operation, while the remaining 20 @entity0 received simple cystectomy only. Five @entity0 (2.8  %, 5/180) had recurrence. Four of them received simple cystectomy while 1 had "conservative" Sistrunk operation. In univariable analysis, age (p  =  0.02), history of previous @entity1 (p  =  0.004) and the type of resection (p  =  0.001) were significantly correlated with disease recurrence. In multivariable analysis, the type of resection turned out to be the most important factor (p  =  0.03) related to recurrence. In the most parsimonious model selected by backward elimination, both history of @entity1 (p  =  0.048) and the type of resection (p  =  0.02) were important predictors of postoperative recurrence. Our results demonstrated that a "conservative" Sistrunk approach could provide a comparably low recurrence rate (0.6  %, 1/160) in dealing with primary thyroglossal dust cysts. Routine dissection of suprahyoid tissue may not be imperative. Overall, the type of resection and history of @entity1 are the most important predictors of recurrence for @entity2 .

title: A 16-year experience in treating XXXX with a "conservative" Sistrunk approach.

answer: @entity2


abstract: OBJECTIVE: To analyze the available information about continuous subcutaneous insulin infusion (CSII) and continuous @entity2 monitoring (CGM) systems in the public health care system of the Community of Madrid. MATERIAL AND METHODS: A survey consisting of 31 items was sent to the 28 endocrinology department of the Madrid public hospitals. Items focused on CSII and CGM and included @entity0 ' registrations, as well as data regarding healthcare, administrative, and logistic aspects. Responses from a total of 20 hospitals where these procedures are used were received from March 2013 to May 2014. Data about pediatric @entity0 were obtained from adult endocrinology departments, except for two hospitals which directly reported the information. RESULTS: A total of 1256 CSII pumps were recorded in the Madrid region, of which 1089 were used by adults, and the remaining 167 by pediatric @entity0 . During 2013, 151 new CSII systems were implanted (12% of the total), while 14 pumps were withdrawn. Availability of @entity0 resources (medical assistance) and the number of staff practitioners experienced in management of these systems widely varied between hospitals. Eighty-five percent of hospitals used retrospective CGM systems, and 40% routinely placed them before starting an insulin pump. Thirteen hospitals (65%) used long-term, real-time CGM systems in selected cases (a total of 67 @entity0 ). CONCLUSIONS: Use of these technologies in @entity1 is unequal between public health care hospitals in Madrid, and is still significantly lower as compared to other countries with similar incomes. However, there appears to be a trend to an increase in their use.

title: Current status of continuous subcutaneous insulin infusion and continuous XXXX monitoring systems in the Community of Madrid.

answer: @entity2


abstract: BACKGROUND: @entity0 with @entity2 ( @entity2 ) have a greater risk of acetabular labral tearing and joint instability, which predispose them to developing @entity1 . The arthroscopic management of @entity2 , however, remains controversial. HYPOTHESIS: Specific clinical characteristics and radiographic parameters correlate with and predict a worsened clinical outcome after hip arthroscopic surgery for @entity2 . STUDY DESIGN: Case control study; Level of evidence, 3. METHODS: Of @entity0 with @entity2 who underwent an arthroscopic procedure between March 2009 and June 2011, there were 28 hips in 28 @entity0 (6 male and 22 female) that met the inclusion criteria. The mean @entity0 age was 28.4 years. Clinical and radiographic follow-up evaluations up to a minimum of 2 years after surgery were performed for all @entity0 . Failure of the procedure was defined as conversion to subsequent surgery or having a T  nnis @entity1 grade of 2 and modified Harris Hip Score (mHHS) that remained <85, and success was defined as @entity0 who did not need subsequent surgery and had an mHHS >85. Univariate analysis and Cox hazard proportional analysis were performed on the 2 subpopulations. RESULTS: There were 9 @entity0 in the failure group (including 3 hips with T nnis grade 2) and 19 @entity0 in the success group. In 22 of 28 @entity0 , the mean mHHS significantly improved from 61.6    18.8 (range, 12.0-85.0) preoperatively to 94.3    7.0 (range, 73.7-100.0) at final follow-up, and the mean Non-Arthritic Hip Score (NAHS) improved from 56.2    13.9 (range, 35.0-81.3) preoperatively to 92.7    9.5 (range, 65.0-100.0) at final follow-up (P < .001, Wilcoxon signed-rank test). Univariate analysis showed that a broken Shenton line was significantly more prevalent in the failure group compared with the success group (8/9 [89%] vs 3/19 [16%] @entity0 , respectively; P < .001). High-grade cartilage delamination (Multicenter Arthroscopy of the Hip Outcomes Research Network [MAHORN] grades 3-5) was significantly higher in the failure group than in the success group (8/9 [89%] vs 3/19 [16%] @entity0 , respectively; P < .001). The median femoral neck-shaft (FNS) angle in the failure group was significantly higher than that in the success group (139   vs 134  , respectively; P = .01). Further, Cox hazard proportional analysis of the failure group showed that the predictors for a poor clinical outcome were the presence of a broken Shenton line, FNS angle >140  , center-edge (CE) angle <19  , body mass index (BMI) >23 kg/m(2), acetabular cartilage damage (MAHORN grades 3-5), and cartilage damage of the femoral head (International Cartilage Repair Society grades 2-4). The most important predictors for a poor clinical outcome at the time of surgery were a broken Shenton line and an FNS angle >140  . CONCLUSION: @entity0 with a broken Shenton line, FNS angle >140  , CE angle <19  , or BMI >23 kg/m(2) at the time of surgery are not good candidates for the arthroscopic management of @entity2 .

title: Clinical and Radiographic Predictors for Worsened Clinical Outcomes After Hip Arthroscopic Labral Preservation and Capsular Closure in XXXX .

answer: @entity2


abstract: BACKGROUND: Analytically sensitive techniques for measuring @entity2 ( @entity2 ) in @entity5 ( @entity5 ) currently require invasive and costly bone @entity4 . These methods include immunohistochemistry (IHC), flow cytometry, quantitative PCR, and next-generation sequencing. An ideal @entity5 @entity2 test would be a serum-based test sensitive enough to detect low concentrations of Ig secreted from multifocal lesions. METHODS: Patient serum with abundant @entity6 before treatment was separated on a 1-dimensional @entity3 -PAGE gel, and the Ig light-chain (LC) band was excised, trypsin digested, and analyzed on a Q Exactive mass spectrometer by LC- @entity1 / @entity1 . We used the peptide's abundance and sequence to identify tryptic peptides that mapped to complementary determining regions of Ig LCs. The clonotypic target tryptic peptides were used to monitor @entity2 in subsequent serum samples with prior affinity enrichment. RESULTS: Sixty-two @entity0 were tested, 20 with no detectable disease by IHC and 42 with no detectable disease by 6-color flow cytometry. A target peptide that could be monitored was identified in 57 @entity0 (91%). Of these 57, detectable disease by LC- @entity1 / @entity1 was found in 52 (91%). CONCLUSIONS: The ability to use LC- @entity1 / @entity1 to measure disease in @entity0 who are negative by bone marrow-based methodologies indicates that a serum-based approach has more analytical sensitivity and may be useful for measuring deeper responses to @entity5 treatment. The method requires no bone @entity4 .

title: Clonotypic Light Chain Peptides Identified for Monitoring Minimal Residual Disease in XXXX Without @entity4 .

answer: @entity5


abstract: BACKGROUND: Analytically sensitive techniques for measuring @entity2 ( @entity2 ) in @entity5 ( @entity5 ) currently require invasive and costly bone @entity4 . These methods include immunohistochemistry (IHC), flow cytometry, quantitative PCR, and next-generation sequencing. An ideal @entity5 @entity2 test would be a serum-based test sensitive enough to detect low concentrations of Ig secreted from multifocal lesions. METHODS: Patient serum with abundant @entity6 before treatment was separated on a 1-dimensional @entity3 -PAGE gel, and the Ig light-chain (LC) band was excised, trypsin digested, and analyzed on a Q Exactive mass spectrometer by LC- @entity1 / @entity1 . We used the peptide's abundance and sequence to identify tryptic peptides that mapped to complementary determining regions of Ig LCs. The clonotypic target tryptic peptides were used to monitor @entity2 in subsequent serum samples with prior affinity enrichment. RESULTS: Sixty-two @entity0 were tested, 20 with no detectable disease by IHC and 42 with no detectable disease by 6-color flow cytometry. A target peptide that could be monitored was identified in 57 @entity0 (91%). Of these 57, detectable disease by LC- @entity1 / @entity1 was found in 52 (91%). CONCLUSIONS: The ability to use LC- @entity1 / @entity1 to measure disease in @entity0 who are negative by bone marrow-based methodologies indicates that a serum-based approach has more analytical sensitivity and may be useful for measuring deeper responses to @entity5 treatment. The method requires no bone @entity4 .

title: Clonotypic Light Chain Peptides Identified for Monitoring Minimal Residual Disease in @entity5 Without XXXX .

answer: @entity4


abstract: OBJECTIVE: The purpose of this study was to analyze modalities of the transition from pediatric to @entity2 care and @entity0 ' acquisition of autonomy. METHOD: This study was conducted using semidirected interviews composed of three major parts: the @entity0 's criteria of transition toward adult healthcare (factors taken into account, anticipation, the @entity0 's opinion, etc.), conditions (teamwork with the neurologists, transmission of the medical record, continuity of health care, etc.), and the role played by social workers and psychologists. We interviewed 10  doctors belonging to six major Parisian hospital units involved in the monitoring of @entity0 and adolescents with @entity2 and working in Pediatric Neurology Departments of the   le-de-France region. RESULTS: For most of the doctors, reaching 18 years of age was the major argument taken into account to consider transition to adult care. According to the doctors interviewed, parents are generally worried when their @entity0 has to find another doctor (7/10). According to eight out of 10  doctors, the neurologist is selected to take over. The doctors recognize the importance of psychologists and social workers even if they are not always included. The process by which the @entity0 gains autonomy depends a great deal on the role played by the pediatricians and parents, although some parents are very protective. This behavior weakens the @entity0 's capacity for autonomy and it varies according to the degree of his or her physical and/or @entity1 . Furthermore, developing autonomy requires interdisciplinary work that is not yet fully in place. CONCLUSION: The lack of structures well-adapted to the uniqueness of each @entity0 and the lack of coordination between the various institutions do not favor the acquisition of autonomy. A network that could efficiently respond to the needs of @entity2 @entity0 as well as medical care tailored to adolescents would be the answer to this dilemma.

title: [A difficult transition from childhood to adult healthcare: The case of XXXX .]

answer: @entity2


abstract: PURPOSE: To evaluate the performance of a series of summary measures of control and to assess reliability in quantifying exodeviation control in intermittent @entity1 . METHODS: A large, simulated dataset of control scores for 10,000 hypothetical @entity0 with intermittent @entity1 was created using Monte Carlo simulations. These data were based on @entity0 with intermittent @entity1 in whom control was assessed twice during one clinical examination, using the office control score (0-5). Each simulated @entity0 had a baseline and 11 subsequent control scores. The repeatability of a series of summary measures of control (the mean of 2 vs the mean of 3 up to the mean of 6), was calculated using 95% limits of agreement (LOA). RESULTS: A total of 322 examinations in 152 @entity0 were used to provide representative distributions of control scores. From the resultant Monte Carlo simulations, the 95% LOAs were 2.60 for 1 distance control score measure, 1.76 for the average of 3, and 1.28 for the average of 6. Therefore using the average of 3 scores, a change of <1.76 would be consistent with short-term variability, whereas a change of >1.76 would suggest a real change in control. CONCLUSIONS: The large dataset of simulated control scores allowed us to assess the variability of specific summary measures of control. We recommend the average of 3 scores (a triple control score) as a new standard for assessing control, providing improved reliability over a single measure, while remaining implementable in clinical practice.

title: Quantifying variability in the measurement of control in intermittent XXXX .

answer: @entity1


abstract: BACKGROUND AND AIMS: Extracorporeal membrane oxygenation (ECMO) is used during pediatric resuscitation in case of refractory @entity4 or @entity1 under maximum therapy. Previous studies describe @entity2 homeostasis dysregulation. The aim of this study was to confirmed of @entity2 homeostasis dysregulation in neonates under ECMO and supposed news explanation. SUBJECTS AND METHODS: From November 2012 to July 2013, we performed a prospective single center observational study. Eleven neonatal @entity0 were included. Blood was obtained before and during ECMO (day 7, 14 and 21) for @entity3 ( @entity3 ), protein adjusted serum @entity2 , ionized @entity2 , @entity5 , and @entity7 levels. All surviving @entity0 underwent a consultation up to 6 months after ECMO weaning. RESULTS: During ECMO @entity3 was inadequately high with normal serum @entity2 on day 7 ( @entity3 : 73.54    40 ng/l; calcemia: 2.33    0.21 mmol/l), day 14 ( @entity3 : 57.63    29.57 ng/l; calcemia: 2.44    0.43 mmol/l) and day 21 ( @entity3 : 54.93    8.43 ng/l; calcemia: 2.13    0.09 mmol/l). The absence of correlation between serum @entity2 and @entity3 levels seem to confirm the dysregulation of @entity3 - serum @entity2 metabolism during ECMO. Six months after ECMO weaning, we noticed @entity6 with normal @entity3 . CONCLUSIONS: We confirmed the existence of severe disturbances of @entity2 homeostasis in neonates on ECMO and supposed the possible damage of @entity2 regulation. We did not succeed in finding clear explanations of these disturbances.

title: XXXX homeostasis disorder during and after neonatal extracorporeal membrane oxygenation.

answer: @entity2


abstract: PURPOSE: To evaluate the contribution of preoperative lymphoscintigraphy to intraoperative lymphatic mapping (ILM) in early cervical @entity1 METHODS: We conducted an ancillary analysis of the multicenter prospective SENTICOL study in early cervical @entity1 . Radiocolloid was injected intracervically on the day before (long protocol) or morning of (short protocol) surgery, lymphoscintigraphy was performed, and the results of a centralized image review were communicated to the surgeons. ILM was performed on combined radioactivity/patent blue detection. Sentinel lymph nodes (SLNs) were electively sampled before routine bilateral pelvic lymphadenectomy by laparoscopy. RESULTS: Of 139 @entity0 in the modified intention-to-diagnose analysis, 114 had centrally reviewed lymphoscintigrams, which showed 352 SLNs in 100 @entity0 . Lymphoscintigraphy and ILM detection rates were 87.8% and 97.8%, respectively. Agreement between lymphoscintigraphy and ILM was low for the number of SLNs (k=0.23; -0.04; 0.49) and bilateral SLNs (k=0.36; 0.2; 0.52). No @entity0 without SLNs by ILM had SLNs by lymphoscintigraphy. Lymphoscintigraphy identified substantial proportions of unusual drainage pathways. No @entity0 with metastatic nodes had SLNs by lymphoscintigraphy but not by ILM in the relevant territory. In 1 of the 2 @entity0 with false-negative SLN results, SLNs were bilateral by lymphoscintigraphy and unilateral by ILM. CONCLUSION: Although the detection rate was lower by lymphoscintigraphy than by ILM, the substantial proportions of SLNs in unusual territories provided valuable guidance for the surgical exploration. Awareness of the limited agreement between lymphoscintigraphic and surgical detection might help surgeons decrease the false-negative rate.

title: Contribution of lymphoscintigraphy to intraoperative sentinel lymph node detection in early cervical XXXX : Analysis of the prospective multicenter SENTICOL cohort.

answer: @entity1


abstract: OBJECTIVE: To find out the short term outcomes of @entity6 repair (LVHR) during the last four years. METHODS: It was a descriptive and prospective case series of 53 consecutive @entity0 out of 107 at Department of General Surgery, Jinnah Post Graduate Medical Center, Unit II, Karachi, from January 2009 to December 2012. These @entity0 were admitted through out @entity0 department with complain of lump, @entity3 and discomfort. Most of the @entity0 were @entity1 . All @entity0 were clinically examined and baseline investigations done. Fifty three (49.5%) @entity0 underwent laparoscopic repair with mesh placement and remaining 54 by open surgical repair. RESULTS: Among 53 @entity0 , mean age was 46 years range (30 - 55). While females were 33(62.2%) and males 20(37.7%). We observed variety of @entity4 , in which midline and @entity4 were predominant. The commonest symptom was lump and dragging sensation. The duration of symptoms ranged between 6 months to one year. About 53 @entity0 (49.5%) had laparoscopic repair with mesh placement. Average hospital stay was two days. Out of 53 @entity0 , 4 (7.5%) had @entity5 at trocar site, seroma in 2(3.7%), 2(3.7%) @entity0 complained of persistent @entity3 postoperatively, port site minor infection was in 2(3.7%) @entity0 , while conversion to open approach was done in 2 (3.7%), @entity2 was observed in one (1.8%) @entity0 . CONCLUSIONS: This study provides the evidence that, laparoscopic repair with mesh placement in @entity6 is safe and effective approach compared to open surgical procedure. It has a low complication rate, less hospital stay and low recurrence.

title: Outcome of four years experience in XXXX repair.

answer: @entity6


abstract: Targeting the @entity3 ( @entity3 ) in @entity0 with @entity5 ( @entity5 ) harboring sensitizing mutations in the @entity4 kinase (TKI) domain has led to a significant change in the management of this disease. The classic or sensitizing mutations are @entity13 mutation in exon 18, in-frame deletions or insertion of exon 19, @entity10 or @entity12 mutation in exon 21. Approximately 90% of these mutations are exon 19 deletion or exon 21 @entity10 point mutation. @entity9 and @entity8 are reversible first-generation inhibitors of mutant @entity3 , and treatment with these agents in the first-line setting has demonstrated a progression-free survival of 9.5-13.7 months. However, the majority of these @entity0 ultimately develop resistance to these drugs. @entity11 is an irreversible pan- @entity3 inhibitor that was developed to circumvent the problem of resistance to first-generation TKIs. The LUX-Lung studies have evaluated the efficacy and @entity1 of @entity11 in treatment-na  ve and refractory @entity5 @entity0 . The promising results of some of these trials led to approval of @entity11 by the US Food and Drug Administration for @entity0 with advanced @entity5 and @entity3 exon 19 deletions or exon 21 ( @entity10 ) substitution mutations. @entity11 causes @entity1 similar to those of the first-generation @entity3 TKIs, such as @entity2 , @entity6 , acne, and @entity7 , and overall is well tolerated. This article focuses on the clinical studies of @entity11 in @entity0 with @entity5 .

title: @entity11 for the treatment of metastatic XXXX .

answer: @entity5


abstract: Targeting the @entity3 ( @entity3 ) in @entity0 with @entity5 ( @entity5 ) harboring sensitizing mutations in the @entity4 kinase (TKI) domain has led to a significant change in the management of this disease. The classic or sensitizing mutations are @entity13 mutation in exon 18, in-frame deletions or insertion of exon 19, @entity10 or @entity12 mutation in exon 21. Approximately 90% of these mutations are exon 19 deletion or exon 21 @entity10 point mutation. @entity9 and @entity8 are reversible first-generation inhibitors of mutant @entity3 , and treatment with these agents in the first-line setting has demonstrated a progression-free survival of 9.5-13.7 months. However, the majority of these @entity0 ultimately develop resistance to these drugs. @entity11 is an irreversible pan- @entity3 inhibitor that was developed to circumvent the problem of resistance to first-generation TKIs. The LUX-Lung studies have evaluated the efficacy and @entity1 of @entity11 in treatment-na  ve and refractory @entity5 @entity0 . The promising results of some of these trials led to approval of @entity11 by the US Food and Drug Administration for @entity0 with advanced @entity5 and @entity3 exon 19 deletions or exon 21 ( @entity10 ) substitution mutations. @entity11 causes @entity1 similar to those of the first-generation @entity3 TKIs, such as @entity2 , @entity6 , acne, and @entity7 , and overall is well tolerated. This article focuses on the clinical studies of @entity11 in @entity0 with @entity5 .

title: XXXX for the treatment of metastatic @entity5 .

answer: @entity11


abstract: @entity3 is an @entity2 caused by clotted vessel-induced cell damage. It is characterized by high morbidity and mortality and is typically treated with a @entity5 (tPA). However, this therapy is limited by temporal constraints. Recently, several studies have focused on cell therapy as an alternative treatment. Most researches have used fixed donor cell administration, and hence, the effect of donor-dependent cell administration is unknown. In this study, we administered 3 types of donor-derived @entity0 umbilical cord blood mesenchymal stem cells (hUCB-MSCs) in the @entity2 boundary zone of the @entity4 @entity1 model. We then performed functional and pathological characterization using rotarod, the limb placement test, and immunofluorescent staining. We observed a significant decrease in neuron number, and notable @entity3 -like motor dysfunction, as assessed by the rotarod test (~40% decrease in time) and the limb placement test (4.5 point increase) in control @entity1 with @entity4 . The neurobehavioral performance of the @entity1 with @entity4 that were treated with hUCB-MSCs was significantly better than that of @entity1 in the vehicle-injected control group. Regardless of which donor cells were used, hUCB-MSC transplantation resulted in an accumulation of neuronal progenitor cells, and angiogenic and tissue repair factors in the @entity2 boundary zone. The neurogenic and angiogenic profiles of the 3 types of hUCB-MSCs were very similar. Our results suggest that intraparenchymal administration of hUCB-MSCs results in significant therapeutic effects in the @entity2 brain regardless of the type of donor.

title: The Effect of Donor-Dependent Administration of XXXX Umbilical Cord Blood-Derived Mesenchymal Stem Cells following Focal Cerebral Ischemia in @entity1 .

answer: @entity0


abstract: @entity3 is an @entity2 caused by clotted vessel-induced cell damage. It is characterized by high morbidity and mortality and is typically treated with a @entity5 (tPA). However, this therapy is limited by temporal constraints. Recently, several studies have focused on cell therapy as an alternative treatment. Most researches have used fixed donor cell administration, and hence, the effect of donor-dependent cell administration is unknown. In this study, we administered 3 types of donor-derived @entity0 umbilical cord blood mesenchymal stem cells (hUCB-MSCs) in the @entity2 boundary zone of the @entity4 @entity1 model. We then performed functional and pathological characterization using rotarod, the limb placement test, and immunofluorescent staining. We observed a significant decrease in neuron number, and notable @entity3 -like motor dysfunction, as assessed by the rotarod test (~40% decrease in time) and the limb placement test (4.5 point increase) in control @entity1 with @entity4 . The neurobehavioral performance of the @entity1 with @entity4 that were treated with hUCB-MSCs was significantly better than that of @entity1 in the vehicle-injected control group. Regardless of which donor cells were used, hUCB-MSC transplantation resulted in an accumulation of neuronal progenitor cells, and angiogenic and tissue repair factors in the @entity2 boundary zone. The neurogenic and angiogenic profiles of the 3 types of hUCB-MSCs were very similar. Our results suggest that intraparenchymal administration of hUCB-MSCs results in significant therapeutic effects in the @entity2 brain regardless of the type of donor.

title: The Effect of Donor-Dependent Administration of @entity0 Umbilical Cord Blood-Derived Mesenchymal Stem Cells following Focal Cerebral Ischemia in XXXX .

answer: @entity1


abstract: Background. Dietary supplementation has been used as a mechanism to augment the immune system. Adjunctive therapy with L-arginine has the potential to improve outcomes in @entity1 . Methods. In a randomized clinical trial 63 @entity0 with smear-positive @entity4 in Markazi Province of Iran were given arginine or placebo for 4 weeks in addition to conventional chemotherapy. The final treatment success, sputum conversion, @entity2 , and clinical symptoms after one and two months were considered as primary outcomes and secondary outcomes were ESR, CRP, and Hg. Data were collected and analyzed with SPSS software (ver. 18). Results. Arginine supplementation reduced constitutional symptoms (P = 0.032) in @entity0 with smear-positive @entity3 at the end of the first month of treatment. Arginine treated @entity0 had significantly increased BMI at the end of the first and second months of treatment (P = 0.032 and P = 0.04) and a reduced CRP at the end of the first month of treatment (P = 0.03) versus placebo group. Conclusion. Arginine is useful as an adjunctive therapy in @entity0 with @entity1 , in which the effects are more likely mediated by the increased production of nitric oxide and improved constitutional symptoms and @entity2 . This trial is registered with Clinical Trials Registry of Iran: IRCT201211179855N2.

title: Arginine adjunctive therapy in XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity9 are increasingly popular drugs of abuse in Australia, and are rising in purity. The rising popularity and purity of @entity9 has notably increased demands upon Australian medical services. @entity9 are sympathomimetic @entity8 with a range of adverse effects upon multiple organ systems. @entity0 are the second leading cause of death in @entity5 abusers, and there appears to be a high prevalence of cardiac pathology. @entity0 frequently seen in @entity5 abusers includes @entity1 , @entity7 , @entity6 , @entity2 and @entity5 -associated @entity3 . The rising prevalence of @entity5 abuse is likely to increase the burden of @entity0 in Australians. A National Parliamentary Enquiry was opened in March 2015 to address concerns regarding the medical and social impacts of @entity5 abuse. From April 2015, a National 'Ice Taskforce' was also created in parallel. Reversal of cardiac pathology appears to be achievable with abstinence from @entity9 and initiation of appropriate treatment. It is key to appreciate that the pathogenesis of @entity5 -induced @entity4 arises as a result of the specific toxic effects of @entity9 . Clinical management is hence individualised; suggested management approaches for @entity5 -induced @entity4 are detailed within this article.

title: The Cardiac Complications of XXXX .

answer: @entity9


abstract: OBJECTIVE: To describe the main epidemiological, clinical, and laboratory features, treatment options and outcome in @entity0 with @entity5 . METHODS: Retrospectively evaluated data were obtained from 317 pediatric @entity0 with @entity5 that were treated at the University Clinic for @entity2 and Febrile Conditions in Skopje, during the period from 1989 to 2011. The medical records and follow-up protocols were used for evaluation. RESULTS: Childhood @entity5 composed 317 (18.7%) of 1691 @entity0 with @entity5 . The @entity0 were median 9 years old, ranging from 7 months to 14 years, and 201 (63.4%) were males. Family history was present in 197 (62.1%), and direct contact with animals occurred in 140 (44.2%) of the @entity0 . The dominant manifestations were @entity3 in 248 (78.2%), @entity1 in 228 (71.9%) and @entity4 in 216 (68.1%). Organ affection was present in 206 (65.0%) of the @entity0 . One hundred and six (33.4%) of the @entity0 were treated with combination composed of two, and 211 (66.6%) with three antimicrobial agents. Relapses were registered in 21 (6.6%), and therapeutic failures in 3 (0.9%) of the @entity0 . CONCLUSIONS: In endemic regions childhood @entity5 represents a significant part of @entity0 cases. Wide spectrum of clinical manifestations, frequent affection of various organ systems and possibility of relapses show that @entity5 could be a serious disease in this age group. The presence of @entity3 , @entity1 , sweating, and affection of various systems in @entity0 from endemic regions should alert pediatricians for the possibility of @entity5 .

title: Childhood XXXX : Review of 317 cases.

answer: @entity5


abstract: The regulation of ketogenesis and gluconeogenesis was studied in isolated, perfused livers from hyper- and euthyroid @entity0 . Experimental conditions were varied with respect to @entity3 and @entity2 concentration in the perfusion medium and with respect to the nutritional state of the @entity0 . 1. The rate of uptake of @entity5 in perfused livers was independent of the thyroid and nutritional states of the animals. 2. In livers from 48-h-fasted @entity0 no difference was found in rates of ketogenesis between the euthyroid and @entity4 livers except when 10 mM @entity3 was present in the perfusate. In recently fed @entity0 the rates of ketogenesis from @entity5 (1 mM) and endogenous substrates were low in euthyroid livers (0.45 and 0.05 mumol/min per g liver, respectively), while these rates in @entity4 livers were (1.333 and 0.136 mumol/min per g liver, respectively). With @entity6 as substrate, high rates of ketogenesis were found in recently fed livers from both euthyroid and @entity4 @entity0 (1.573 and 1.717 mumol/min per g liver, respectively). 3. Without @entity5 in the perfusion medium the rate of gluconeogenesis from low (1 mM) @entity3 concentrations in livers from 48 h-fasted- @entity0 was slightly increased in the @entity4 state (0.548 mumol/min per g liver) compared to the euthyroid state (0.408 mumol/min per g liver). When @entity3 concentration in the perfusion medium was raised to 10 mM the rate of gluconeogenesis was increased 4-fold in the @entity4 livers (1.800 mumol/min per g liver) but only 20% in the euthyroid livers (0.490 mumol/min per g liver). The presence of @entity5 (1 mM) had no effect on the rate of gluconeogenesis from low @entity3 concentrations in livers form 48-h-fasted animals of either thyroid state. At 10 mM @entity3 the inclusion of @entity5 caused a pronounced stimulation of gluconeogenesis in euthyroid livers (from 0.490 to 1.766 mumol/min per g liver) but not in @entity4 livers (from 1.800 to 1.973 mumol/min per g liver) so that the difference in the rate of gluconeogenesis between the two thyroid states disappeared. 4. The content of endogenous substrates was measured in liver biopsies taken before perfusion. The glycogen concentration was independent of the thyroid state in 48-h fasted animals. The @entity1 content was independent of the thyroid state in recently fed animals. In recently fed animals the glycogen content was reduced by 90% in @entity4 animals, and in 48-h-fasted animals the @entity1 content was reduced by 50% in @entity4 animals. 5. The energy cost of gluconeogenesis from @entity3 appeared to be independent of the thyroid state.

title: Thyroid hormone-induced changes in gluconeogenesis and ketogenesis in perfused XXXX liver.

answer: @entity0


abstract: OBJECTIVE: To analyze the efficacy of the method for selecting the distal level of fusion in treatment of @entity3 in @entity0 with @entity4 . BACKGROUND: The fusion area needs to include all the @entity1 in @entity4 @entity0 ; however, precise levels of the distal fixation have not been determined yet. STUDY DESIGN: Retrospective cohort review. MATERIALS AND METHODS: Thirty-six @entity0 were operated in the Department of @entity0 and Adolescent Spine Pathology between 2007 and 2010. These @entity0 were divided into two groups: in group I (n = 29) a lower instrumented vertebra corresponded to the sagittal stable one and in group II (n = 7) - this vertebra located proximally. RESULTS: The mean preoperative kyphosis was 79.3      11.6  , the postoperative - 40.6      11.9   (correction of 49.9%), loss of correction was 4.9      7.0  . Sagittal balance changed from -0.3    3.2 cm before surgery to -1.7    2.1 cm after surgery. Distal junctional kyphosis developed in 1 case (4%) in Group I, and in 5 cases (71%) in Group II. CONCLUSION: A distal level of instrumentation ending at the first lordotic vertebra is not justified and causes violation of sagittal balance and development of @entity2 . The inclusion of a sagittal stable vertebra in fusion prevents the development of this undesirable situation.

title: Selection Of The Optimal Level Of Distal Fixation For Correction Of XXXX 's Hyperkyphosis.

answer: @entity4


abstract: BACKGROUND AND OBJECTIVE: To compare efficacy of monthly treatment with bevacizumab or ranibizumab for @entity1 due to @entity2 . @entity0 AND METHODS: Randomized, multicenter, comparative trial (ClinicalTrials.gov identifier: NCT01428388). @entity0 were randomized 1:1 to receive monthly treatment with bevacizumab or ranibizumab. The primary outcome was change in central foveal thickness at 6 months compared to baseline. RESULTS: The trial randomized 98 @entity0 to treatment with bevacizumab or ranibizumab. At 6 months, there were no differences in change in central foveal thickness between groups (bevacizumab: mean reduction of 212.6   m, 95% confidence interval [CI], -288.3 to -137.0; ranibizumab: mean reduction of 243.8   m, 95% CI, -309.6 to -178.0; P = .72, analysis of variance [ANOVA]). Both groups showed similar functional outcomes (bevacizumab: 0.33 logMAR gain, 95% CI, -0.47 to -0.18; ranibizumab: 0.34 logMAR gain, 95% CI, -0.45 to -0.23; P = .38, ANOVA). CONCLUSION: In the treatment of @entity2 , bevacizumab and ranibizumab have similar effects on reducing macular thickness and improving visual acuity. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:844-850.].

title: Bevacizumab Versus Ranibizumab in the Treatment of XXXX Due to @entity2 : 6-Month Results of the CRAVE Study.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVE: To compare efficacy of monthly treatment with bevacizumab or ranibizumab for @entity1 due to @entity2 . @entity0 AND METHODS: Randomized, multicenter, comparative trial (ClinicalTrials.gov identifier: NCT01428388). @entity0 were randomized 1:1 to receive monthly treatment with bevacizumab or ranibizumab. The primary outcome was change in central foveal thickness at 6 months compared to baseline. RESULTS: The trial randomized 98 @entity0 to treatment with bevacizumab or ranibizumab. At 6 months, there were no differences in change in central foveal thickness between groups (bevacizumab: mean reduction of 212.6   m, 95% confidence interval [CI], -288.3 to -137.0; ranibizumab: mean reduction of 243.8   m, 95% CI, -309.6 to -178.0; P = .72, analysis of variance [ANOVA]). Both groups showed similar functional outcomes (bevacizumab: 0.33 logMAR gain, 95% CI, -0.47 to -0.18; ranibizumab: 0.34 logMAR gain, 95% CI, -0.45 to -0.23; P = .38, ANOVA). CONCLUSION: In the treatment of @entity2 , bevacizumab and ranibizumab have similar effects on reducing macular thickness and improving visual acuity. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:844-850.].

title: Bevacizumab Versus Ranibizumab in the Treatment of @entity1 Due to XXXX : 6-Month Results of the CRAVE Study.

answer: @entity2


abstract: INTRODUCTION: Differences in the risk of being exposed to @entity1 ( @entity1 ) in the workplace may occur not only between countries, but also within a country among socio-economic groups. OBJECTIVES: The aim of the study was to examine the associations of exposure to @entity1 at worksites with selected factors in non-smoking Romanian employees. MATERIAL AND METHODS: Data on exposure to @entity1 at worksites and other characteristics of respondents came from the Global Adult @entity0 Survey (GATS). GATS is a nationally representative household survey of adults 15 years of age or older, using a standard protocol. RESULTS: Among 4,517 respondents who completed the questionnaire there were 1,333 subjects, including 859 non-smokers who worked in an indoor area outside the home. The prevalence of exposure to @entity1 was 31.2% among non-smoking male and 23.9% among non-smoking female employees (p<0.05). Employees with primary education had odds of exposure to @entity1 at work nearly twice as high, compared to the respondents having high education attainment (OR=1.9; 95% CI: 1.2-2.9). Moreover, exposure to @entity1 at worksites was significantly associated with a low level of support for @entity0 control policies among workers (OR = 1.8; 95% CI: 1.2-2.8). CONCLUSIONS: In spite of the increasing presence of smoking bans in public and workplaces, enforcement still seems to be unsuccessful in the occupational space in Romania. In order to reduce @entity1 exposure in workplaces, strengthening support for @entity0 control policies is essential.

title: Disparities in exposure to XXXX smoke pollution at Romanian worksites.

answer: @entity0


abstract: BACKGROUND: MicroRNAs (miRNAs) contribute to @entity0 progression via regulating mRNAs involved in renal homeostasis. However, their association with clinical outcome remains poorly understood. MATERIALS AND METHODS: We performed miRNA and mRNA expression profiling on renal biopsy sections by qPCR (miRNA) and microarrays (mRNA) in a discovery (n=43) and in a validation (n=29) cohort. miRNAs differentiating stable and progressive cases were inversely correlated to putative target mRNAs, which were further characterized by pathway analysis using KEGG pathways. RESULTS: @entity12 , miR-140-3p, miR-532-3p, miR-194, @entity15 , @entity7 , and @entity9 were downregulated in progressive cases. These 7 miRNAs correlated to upregulated 29 target mRNAs involved in inflammatory response, cell-cell-interaction, apoptosis, and intracellular signaling. In particular @entity9 and miR-532-3p were associated with distinct biological processes via the expression of their target mRNAs: Reduced expression of @entity9 in progressive disease correlated with the upregulation of target mRNAs participating in inflammatory pathways ( @entity8 , @entity2 , @entity11 , @entity16 , @entity10 , @entity1 , @entity14 , and @entity4 ). Progressive cases also showed a lower expression of miR-532-3p and an increased expression of target transcripts involved in apoptosis pathways ( @entity5 , @entity3 / @entity3 , @entity13 , and @entity6 ). In the validation cohort we confirmed the decreased expression of @entity9 and miR-532-3p, and the inverse correlation of these miRNAs with the expression of 9 of the 12 target genes. The levels of the identified miRNAs and the target mRNAs correlated to clinical parameters and histological damage indices. CONCLUSIONS: These results suggest the involvement of specific miRNAs and mRNAs in biological pathways associated with the progression of @entity0 . This article is protected by copyright. All rights reserved.

title: Renal microRNA- and RNA-profiles in progressive XXXX .

answer: @entity0


abstract: CONTEXT: @entity7 ( @entity7 ) and @entity1 are considered common findings of the @entity1 in echocardiography studies. OBJECTIVE: To evaluate the frequency of @entity7 , @entity2 and @entity1 was undertaken in @entity0 with @entity4 using cardiac magnetic resonance imaging (CMRi) before and after 12 months of @entity6 long-acting repeatable treatment. @entity0 AND METHODS: Consecutive @entity0 with active @entity4 submitted to biochemical analysis and CMRi before and after 12 months of treatment. Additionally, echocardiography was performed before treatment. RESULTS: Forty consecutive @entity0 were evaluated using CMRi at baseline and 30 @entity0 were reevaluated after 12 months of treatment. Additionally, 29 of these @entity0 were submitted to echocardiography. Using CMRi, the frequency of @entity7 was 5%. The mean left ventricular mass index (LVMi) was 61.73    18.8 g/m(2). The mean @entity3 ( @entity3 ) was 61.85    9.2%, and all @entity0 had normal systolic function. Late @entity5 enhancement was present in five @entity0 (13.5%), and one @entity0 (3.5%) had an increased extracellular volume. After treatment, 12 @entity0 (40%) had criteria for disease control. No clinically relevant differences in cardiac variables before and after treatment were observed. Additionally, there was no difference in LVMi and @entity3 among @entity0 with and without disease control. Using echocardiography, 31% of the @entity0 had @entity7 , mean LVMi was 117.8    46.3 g/m(2) and mean @entity3 was 67.3    4.4%. All @entity0 had normal systolic function. CONCLUSIONS: We demonstrated by CMRi, the gold-standard method, that @entity0 with active @entity4 might have a lower prevalence of @entity2 than previously reported.

title: Low Frequency of XXXX Using Cardiac Magnetic Resonance Imaging in an @entity4 Contemporary Cohort.

answer: @entity1


abstract: CONTEXT: @entity7 ( @entity7 ) and @entity1 are considered common findings of the @entity1 in echocardiography studies. OBJECTIVE: To evaluate the frequency of @entity7 , @entity2 and @entity1 was undertaken in @entity0 with @entity4 using cardiac magnetic resonance imaging (CMRi) before and after 12 months of @entity6 long-acting repeatable treatment. @entity0 AND METHODS: Consecutive @entity0 with active @entity4 submitted to biochemical analysis and CMRi before and after 12 months of treatment. Additionally, echocardiography was performed before treatment. RESULTS: Forty consecutive @entity0 were evaluated using CMRi at baseline and 30 @entity0 were reevaluated after 12 months of treatment. Additionally, 29 of these @entity0 were submitted to echocardiography. Using CMRi, the frequency of @entity7 was 5%. The mean left ventricular mass index (LVMi) was 61.73    18.8 g/m(2). The mean @entity3 ( @entity3 ) was 61.85    9.2%, and all @entity0 had normal systolic function. Late @entity5 enhancement was present in five @entity0 (13.5%), and one @entity0 (3.5%) had an increased extracellular volume. After treatment, 12 @entity0 (40%) had criteria for disease control. No clinically relevant differences in cardiac variables before and after treatment were observed. Additionally, there was no difference in LVMi and @entity3 among @entity0 with and without disease control. Using echocardiography, 31% of the @entity0 had @entity7 , mean LVMi was 117.8    46.3 g/m(2) and mean @entity3 was 67.3    4.4%. All @entity0 had normal systolic function. CONCLUSIONS: We demonstrated by CMRi, the gold-standard method, that @entity0 with active @entity4 might have a lower prevalence of @entity2 than previously reported.

title: Low Frequency of @entity1 Using Cardiac Magnetic Resonance Imaging in an XXXX Contemporary Cohort.

answer: @entity4


abstract: BACKGROUND: @entity2 is a marker of future @entity1 ( @entity1 ) risk, yet epidemiological studies have yielded inconsistent results. We therefore studied the association between @entity2 and @entity1 under diverse circumstances. METHODS AND RESULTS: Literature-based meta-analysis of prospective observational studies with >=   12  months of follow-up published in Medline and having information on endothelial function and @entity1 outcomes. Tabular data on @entity0 characteristics, endothelial function assessments and incident @entity1 outcomes were abstracted from individual studies. Random-effects meta-analysis was used to quantify pooled associations, and I(2) statistic to evaluate between-study heterogeneity. Potential sources of heterogeneity were explored by subgroup analyses and meta-regression. Thirty five studies involving 17,206 @entity0 met the inclusion criteria. During more than 80,000 @entity0 -years of observation, up to 2755 @entity1 events were accrued, yielding a pooled relative risk (RR) of 1.25 (95% confidence interval 1.15-1.35) for @entity1 comparing top (i.e. more severe) vs. bottom (less severe) third of @entity2 . There was significant between-study heterogeneity and evidence of publication bias. RRs varied importantly according to the method used to ascertain endothelial function, and were higher among older individuals and among @entity0 with risk factors for @entity1 or established @entity1 at baseline. CONCLUSIONS: Although @entity2 is an important determinant of cardiovascular outcomes in @entity0 with pre-existing @entity1 , current evidence base does not support its use as a potentially useful measurement for risk stratification in @entity0 at lower risk of @entity1 .

title: A meta-analysis of published studies of XXXX does not support its routine clinical use.

answer: @entity2


abstract: BACKGROUND: @entity1 is one of the most common cariogenic microorganisms. Use of natural anticariogenic agents, such as @entity2 has been well-established in the literature. On the other hand, there is a scarcity of studies that have reported the antimicrobial potential of Propolis as an anticariogenic chewing agent; hence, the present study was designed. AIMS: To evaluate and compare the anticariogenic action of two commercial chewing gums Propolis and Xylitol on the salivary @entity1 count in a group of @entity0 from Bengaluru city. SETTINGS AND DESIGN: Clinical setting and experimental design. MATERIALS AND METHODS: Thirty healthy @entity0 aged 8-11 years with decayed, missing, and filled teeth (dmft)/DMFT index score >= 3 were included in the study. Before the test, unstimulated saliva was collected. @entity0 divided into Group I and II were given Propolis and Xylitol chewing gums respectively; to chew for 15 min. Saliva samples were then collected at 15 min (just after spitting) and after 1 h. The amount of @entity1 in saliva was evaluated using a selective media (MSAB). In addition, compliance of the two chewing gums among the @entity0 was tested with a questionnaire. STATISTICAL ANALYSIS USED: Student's t-test. RESULTS: Six samples out of 30 were excluded due to no growth. The total number of bacterial colonies was significantly reduced when compared to baseline in both the groups. Propolis gum showed statistically significant reduction in the number of colonies as compared to Xylitol. Xylitol gum was more preferred than Propolis gum by the @entity0 . CONCLUSIONS: Propolis chewing gum can be used as an anticariogenic agent in @entity0 .

title: The effect of Propolis and Xylitol chewing gums on salivary XXXX count: A clinical trial.

answer: @entity1


abstract: BACKGROUND: To determine wound location according to the angiosome concept and to investigate the feasibility and success of angiosome-based revascularization in below-the-knee (BTK) arteries. METHODS: This was a retrospective study of 161 @entity0 (67.5      25.5  years, 66.5% diabetics) with @entity1 and a foot ulcer, stage Rutherford 5-6, who underwent percutaneous transluminal angioplasty on BTK arteries in 2012. We evaluated feasibility of angiosome-targeted revascularization and the number of angiosomes affected by a wound in each @entity0 . @entity0 were divided into 3 groups depending on how many BTK vessels were suitable for revascularization. The feasibility was analyzed in each group and in relation to number of affected angiosomes. RESULTS: The wound(s) interfered with one angiosome in only 39 (24.0%) cases. Direct flow into affected angiosome was successfully achieved in 98 (60.9%) cases. If @entity2 was limited in one angiosome, the targeted revascularisation was possible in 27 cases (69.2%), if @entity2 was extended over 2 angiosomes it was possible in 65 cases (86.7%), if 3 angiosomes were affected it was possible in 36 cases (85.7%), when 4 angiosomes were affected the rate dropped to 25.0% and @entity2 extended over 5 angiosomes had no possibility of revascularization. CONCLUSIONS: In @entity1 , the tissue lesion affects several angiosomes in majority of the cases. In thus far published literature, there is existence of more approaches of angiosome-targeted revascularization when more than one angiosome is clinically involved and therefore consensus needs to be achieved for the accurate definition.

title: The Feasibility of Angiosome-Targeted Endovascular Treatment in @entity0 with XXXX and Foot Ulcer.

answer: @entity1