abstract: @entity2 is often used in the treatment of @entity0 with @entity9 , either preoperatively to facilitate nephrectomy or as palliative therapy in advanced cases. Eighteen @entity0 (18/58; 31%) underwent @entity2 in our department since 1979, initial 10 cases with Gelfoam and steel coil (group G) and recent 8 cases with absolute @entity6 (group A). Clinical studies of daily changes of symptoms and blood chemistry in both groups after embolization were compared and the results were as follows: @entity5 was noted immediately after embolization but thereafter well controlled without analgesics in group A. The @entity0 in group G experienced no @entity3 during the procedure of embolization but have had moderate @entity5 of two or three days' duration with @entity8 and required surgical procedure within a few days after embolization. Post embolization fever in group A was described as higher than that in group G significantly. @entity4 was noted to be persistent for up to seven days and blood chemistry showed transient marked elevations of GOT, @entity11 and LDH immediately after the procedure without significant value in both groups. Embolization to advanced @entity1 with many parasitic vessels or massive local invasion may not always be available for remaining of viable-appearing @entity1 cells in venous lumen, as if palliative treatment. Absolute @entity6 may be more useful as the embolizing substance than Gelfoam and steel coil by reason of producing wide severe @entity7 of diseased kidney. Broad marked @entity10 may make pathological diagnosis difficult. Immunological effects of @entity2 were not observed in short term @entity0 survival.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ @entity2 for XXXX ].

answer: @entity9


abstract: @entity2 is often used in the treatment of @entity0 with @entity9 , either preoperatively to facilitate nephrectomy or as palliative therapy in advanced cases. Eighteen @entity0 (18/58; 31%) underwent @entity2 in our department since 1979, initial 10 cases with Gelfoam and steel coil (group G) and recent 8 cases with absolute @entity6 (group A). Clinical studies of daily changes of symptoms and blood chemistry in both groups after embolization were compared and the results were as follows: @entity5 was noted immediately after embolization but thereafter well controlled without analgesics in group A. The @entity0 in group G experienced no @entity3 during the procedure of embolization but have had moderate @entity5 of two or three days' duration with @entity8 and required surgical procedure within a few days after embolization. Post embolization fever in group A was described as higher than that in group G significantly. @entity4 was noted to be persistent for up to seven days and blood chemistry showed transient marked elevations of GOT, @entity11 and LDH immediately after the procedure without significant value in both groups. Embolization to advanced @entity1 with many parasitic vessels or massive local invasion may not always be available for remaining of viable-appearing @entity1 cells in venous lumen, as if palliative treatment. Absolute @entity6 may be more useful as the embolizing substance than Gelfoam and steel coil by reason of producing wide severe @entity7 of diseased kidney. Broad marked @entity10 may make pathological diagnosis difficult. Immunological effects of @entity2 were not observed in short term @entity0 survival.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ XXXX for @entity9 ].

answer: @entity2


abstract: UNASSIGNED: @entity2 is one of the most relevant pathogens causing clinical and subclinical, chronic @entity4 in dairy animals. Routinely, @entity4 pathogens are isolated and classified to genus or species level, and regarded as single entities. However, @entity2 includes a broad range of genotypes with distinct pathogenic and epidemiologic characteristics. The objective of the present study was to assess the host-specificity of @entity2 causing @entity4 in dairy animals, based on phylogenetic and genotypic characterization as well as the presence of virulence and antimicrobial resistance genes in the pathogen genome. @entity2 isolates from @entity4 in @entity0 , @entity1 and @entity3 in Israel, and from @entity0 in Germany, the USA and Italy, were compared by the following methods: a. Bayesian phylogenetic comparison of sequences of genes nuc, coa, lukF and clfA, b. genotyping by spa and agr typing, and assignment to MLST Clonal Complexes (MLST CC), and c. the presence of a broad array of virulence and antimicrobial resistance genes. Overall, phylogenetic, virulence and genotyping approaches agreed with each other. @entity0 isolates could be differentiated from @entity1 and @entity3 isolates with all three methods, with different resolution. In two phylogenetic clusters, segregation was found also between @entity0 isolates from Israel and abroad. @entity1 and @entity3 ' isolates showed less variability than isolates from @entity0 in all methods used. In conclusion, different @entity2 lineages are associated to @entity0 in contrast to @entity3 and @entity1 , suggesting co-evolution between pathogen and host species. Modern diagnostics approaches should aim to explore molecular data for a better understanding and cost-effective management of @entity4 .

title: Host-specificity of XXXX causing intramammary infections in dairy animals assessed by genotyping and virulence genes.

answer: @entity2


abstract: The haemodynamic tolerance of intravenous @entity4 was evaluated during the acute phase of @entity1 . This is a beta-blocker with an intrinsic beta-stimulant effect. The study consisted of 14 @entity0 (10 cases of inferior @entity3 and 4 cases of anterior @entity3 ) with a mean capillary pressure of less than 20 mmHg and a cardiac index greater than 2 l X min-1 X m-2. The minimal dose of @entity4 was 0.05 mg X kg-1 X h-1 and the maximal dose was 0.125 mg X kg-1 X h-1. The intravenous infusion of @entity4 was commenced between 3 and 12 hours (average: 7.5 hours) after the @entity3 and was continued for 48 hours, at which time it was replaced by oral administration. The mean total intravenous dose was 409 mg (from 190 to 510 mg). Two @entity0 were excluded from the protocol because of the development of 2nd degree @entity2 several minutes after the beginning of the infusion. The basal values of the cardiac index (2.7 l X min-1 X m-2 +/- 0.37), the mean capillary pressure (9.4 mmHg +/- 2.7) and the systolic index (38.3 ml/m2 +/- 6.4) did not change significantly during the infusion, in the 14 @entity0 studied. The double product, heart rate x blood pressure, decreased from the mean basal value of 9,443 to 7,680 at 24 hours and to 7,000 at 48 hours (p less than 0.05). @entity4 does not depress left ventricular function, provided that it is reserved for @entity0 with class I or II disease according to Killip and Kimball's classification.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Hemodynamic effects of intravenous XXXX in the acute phase of @entity1 ].

answer: @entity4


abstract: The haemodynamic tolerance of intravenous @entity4 was evaluated during the acute phase of @entity1 . This is a beta-blocker with an intrinsic beta-stimulant effect. The study consisted of 14 @entity0 (10 cases of inferior @entity3 and 4 cases of anterior @entity3 ) with a mean capillary pressure of less than 20 mmHg and a cardiac index greater than 2 l X min-1 X m-2. The minimal dose of @entity4 was 0.05 mg X kg-1 X h-1 and the maximal dose was 0.125 mg X kg-1 X h-1. The intravenous infusion of @entity4 was commenced between 3 and 12 hours (average: 7.5 hours) after the @entity3 and was continued for 48 hours, at which time it was replaced by oral administration. The mean total intravenous dose was 409 mg (from 190 to 510 mg). Two @entity0 were excluded from the protocol because of the development of 2nd degree @entity2 several minutes after the beginning of the infusion. The basal values of the cardiac index (2.7 l X min-1 X m-2 +/- 0.37), the mean capillary pressure (9.4 mmHg +/- 2.7) and the systolic index (38.3 ml/m2 +/- 6.4) did not change significantly during the infusion, in the 14 @entity0 studied. The double product, heart rate x blood pressure, decreased from the mean basal value of 9,443 to 7,680 at 24 hours and to 7,000 at 48 hours (p less than 0.05). @entity4 does not depress left ventricular function, provided that it is reserved for @entity0 with class I or II disease according to Killip and Kimball's classification.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Hemodynamic effects of intravenous @entity4 in the acute phase of XXXX ].

answer: @entity1


abstract: Background This study aimed to investigate the @entity3 ( @entity3 ) levels in serum and synovial fluid (SF) of @entity0 with primary @entity2 ( @entity1 ) and to exam its correlation with radiographic and symptomatic severity of the disease. Material and Methods A total of 37 knee @entity1 @entity0 and 20 healthy controls were enrolled in this study. Knee @entity1 radiographic grading was performed according to the Kellgren-Lawrence (KL) grading system by evaluating X-ray changes observed in anteroposterior knee radiography. Symptomatic severity of the disease was evaluated according to the Western Ontario @entity1 Index (WOMAC) scores. @entity3 levels in serum and SF were determined using enzyme-linked immunosorbent assay. Results Serum @entity3 level in @entity0 with knee @entity1 was higher than that in healthy controls. Knee @entity1 @entity0 with KL grade 4 showed significantly elevated @entity3 levels in the serum and SF compared with those with KL grade 2 and 3. Knee @entity1 @entity0 with KL grade 3 had significant higher SF levels of @entity3 than those with KL grade 2. @entity3 levels in the serum and SF of knee @entity1 @entity0 were both positively correlated with KL grades and WOMAC scores. Conclusions @entity3 levels in serum and SF were closely related to the radiographic and symptomatic severity of knee @entity1 and may serve as an alternative biochemical parameter to determine disease severity of primary knee @entity1 .

title: Correlation of @entity3 levels in serum and synovial fluid with disease severity of XXXX .

answer: @entity2


abstract: Background This study aimed to investigate the @entity3 ( @entity3 ) levels in serum and synovial fluid (SF) of @entity0 with primary @entity2 ( @entity1 ) and to exam its correlation with radiographic and symptomatic severity of the disease. Material and Methods A total of 37 knee @entity1 @entity0 and 20 healthy controls were enrolled in this study. Knee @entity1 radiographic grading was performed according to the Kellgren-Lawrence (KL) grading system by evaluating X-ray changes observed in anteroposterior knee radiography. Symptomatic severity of the disease was evaluated according to the Western Ontario @entity1 Index (WOMAC) scores. @entity3 levels in serum and SF were determined using enzyme-linked immunosorbent assay. Results Serum @entity3 level in @entity0 with knee @entity1 was higher than that in healthy controls. Knee @entity1 @entity0 with KL grade 4 showed significantly elevated @entity3 levels in the serum and SF compared with those with KL grade 2 and 3. Knee @entity1 @entity0 with KL grade 3 had significant higher SF levels of @entity3 than those with KL grade 2. @entity3 levels in the serum and SF of knee @entity1 @entity0 were both positively correlated with KL grades and WOMAC scores. Conclusions @entity3 levels in serum and SF were closely related to the radiographic and symptomatic severity of knee @entity1 and may serve as an alternative biochemical parameter to determine disease severity of primary knee @entity1 .

title: Correlation of XXXX levels in serum and synovial fluid with disease severity of @entity2 .

answer: @entity3


abstract: BACKGROUND: The increasing incidence and prevalence of @entity1 ( @entity1 ) demands new therapeutic approaches for treating the disease. We investigated the therapeutic efficacy of immunomodulator @entity5 ointment (fingolimod) for mite-induced intractable @entity1 using an NC/Nga @entity0 model. METHODS: Female NC/Nga @entity0 that developed severe @entity1 were divided into four groups: (1) @entity5 (0.001% @entity5 ointment), (2) @entity2 ( @entity6 ointment) (3) @entity4 ( @entity4 ointment), and (4) ointment base (hydrophilic petrolatum), all of which received treatment six times per week. Therapeutic efficacy after two weeks was evaluated in terms of @entity1 severity, histochemical observations (epidermal @entity3 , mast cell accumulation, and CD3(+) T cell infiltration), transepidermal water loss (TEWL), and epidermal barrier function (filaggrin expression). RESULTS: @entity4 treatment showed little effect, confirming that the @entity1 was intractable. In the @entity5 group, @entity1 improved significantly compared with the ointment base group, as did epidermal @entity3 , mast cell accumulation, and CD3(+) T cell infiltration. In contrast, @entity1 in the @entity2 and @entity4 groups did not improve significantly, nor did epidermal @entity3 or mast cell accumulation. Furthermore, in the @entity5 group, TEWL decreased significantly compared with the ointment base group, and filaggrin expression significantly increased compared with the @entity4 and ointment base groups. CONCLUSIONS: @entity5 ointment is a promising candidate for treatment of intractable @entity1 . These findings also provide the first evidence that @entity5 ointment ameliorates epidermal barrier function.

title: Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator XXXX ointment (fingolimod) in NC/Nga @entity0 .

answer: @entity5


abstract: BACKGROUND: The increasing incidence and prevalence of @entity1 ( @entity1 ) demands new therapeutic approaches for treating the disease. We investigated the therapeutic efficacy of immunomodulator @entity5 ointment (fingolimod) for mite-induced intractable @entity1 using an NC/Nga @entity0 model. METHODS: Female NC/Nga @entity0 that developed severe @entity1 were divided into four groups: (1) @entity5 (0.001% @entity5 ointment), (2) @entity2 ( @entity6 ointment) (3) @entity4 ( @entity4 ointment), and (4) ointment base (hydrophilic petrolatum), all of which received treatment six times per week. Therapeutic efficacy after two weeks was evaluated in terms of @entity1 severity, histochemical observations (epidermal @entity3 , mast cell accumulation, and CD3(+) T cell infiltration), transepidermal water loss (TEWL), and epidermal barrier function (filaggrin expression). RESULTS: @entity4 treatment showed little effect, confirming that the @entity1 was intractable. In the @entity5 group, @entity1 improved significantly compared with the ointment base group, as did epidermal @entity3 , mast cell accumulation, and CD3(+) T cell infiltration. In contrast, @entity1 in the @entity2 and @entity4 groups did not improve significantly, nor did epidermal @entity3 or mast cell accumulation. Furthermore, in the @entity5 group, TEWL decreased significantly compared with the ointment base group, and filaggrin expression significantly increased compared with the @entity4 and ointment base groups. CONCLUSIONS: @entity5 ointment is a promising candidate for treatment of intractable @entity1 . These findings also provide the first evidence that @entity5 ointment ameliorates epidermal barrier function.

title: Therapeutic approach to mite-induced intractable dermatitis using novel immunomodulator @entity5 ointment (fingolimod) in NC/Nga XXXX .

answer: @entity0


abstract: BACKGROUND: @entity0 with @entity10 ( @entity10 ) @entity5 or @entity8 produce serum IgE specific to the antigens of @entity10 or @entity7 Ascaris, respectively. Although @entity0 IgE cross-reactivity has been reported between @entity10 and Ascaris antigens, it remains unclear whether it contributes to the pathogenesis of @entity2 . We herein investigated the induction of cross-reactive antibodies and T cells in @entity1 and effects of airway exposure to @entity10 antigens after preimmunization with Ascaris antigens. METHODS: @entity1 were intraperitoneally immunized with @entity10 or Ascaris antigens with Alum, followed by the intranasal administration of @entity10 antigens. Serum antigen-specific IgE and IgG were measured by ELISA. Cytokine release in splenocytes from Ascaris-immunized @entity1 upon in  vitro restimulation with @entity10 antigens were measured by ELISA. RESULTS: Immunization with Ascaris or @entity10 antigens induced cross-reactive @entity9 . Splenocytes from Ascaris-immunized @entity1 released @entity3 and @entity6 in response to the restimulation with @entity10 antigens. Subsequent airway exposure to @entity10 antigens promoted the induction of @entity10 -specific IgE and upregulation of @entity10 -specific @entity9 in Ascaris-immunized @entity1 , whereas these responses were not detected or smaller without the Ascaris presensitization. CONCLUSIONS: We demonstrated that the immunization of na  ve @entity1 with Ascaris antigens induced production of antibodies and differentiation of Th2 cells, which were cross-reactive to @entity10 antigens, and accelerated induction of serum @entity10 -specific IgE upon subsequent airway exposure to @entity10 antigens in @entity1 . These results suggest that sensitization to @entity10 towards IgE-mediated @entity2 is faster in individuals with a previous history of @entity4 than in those without presensitization to Ascaris.

title: Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in XXXX .

answer: @entity1


abstract: STUDY DESIGN: Single group, pretest-post-test study. OBJECTIVES: To determine the effects of a non-task-specific, voluntary, progressive aerobic exercise training (AET) intervention on fitness and walking-related outcomes in ambulatory adults with chronic motor-incomplete SCI. SETTING: Rehabilitation research center. METHODS: Ten ambulatory individuals (50% female; 57.94  9.33 years old; 11.11  9.66 years postinjury) completed voluntary, progressive moderate-to-vigorous intensity AET on a recumbent stepper 3 days per week for 6 weeks. The primary outcome measures were aerobic capacity (VO2peak (volume of @entity1 that the body can use during physical exertion)) and self-selected @entity3 ( @entity3 ). Secondary outcome measures included walking economy, 6-minute walk test (6MWT), daily step counts, Walking Index for @entity2 (WISCI-II), Dynamic Gait Index (DGI) and Berg Balance Scale (BBS). RESULTS: Nine @entity0 completed all testing and training. Significant improvements in aerobic capacity (P=0.011), @entity3 (P=0.023), the percentage of VO2peak used while walking at self-selected speed (P=0.03) and daily step counts (P=0.025) resulted following training. CONCLUSIONS: The results indicate that total-body, voluntary, progressive AET is safe, feasible, and effective for improving aerobic capacity, walking speed, and select walking-related outcomes in an exclusively ambulatory SCI sample. This study suggests the potential for non-task-specific aerobic exercise to improve walking following incomplete SCI and builds a foundation for further investigation aimed at the development of exercise based rehabilitation strategies to target functionally limiting impairments in ambulatory individuals with chronic SCI.

title: Effects of aerobic exercise training on fitness and walking-related outcomes in ambulatory individuals with chronic incomplete XXXX .

answer: @entity2


abstract: BACKGROUND: The precise location of truly active reentry circuits of typical @entity1 ( @entity1 ) has not been well identified. The purpose of this study was to verify our hypothesis that the posterior block line is located along the posteromedial @entity3 (PMRA) and the crista terminalis (CT) is the anterior pathway of @entity1 , with real-time intracardiac echo (ICE). METHODS: The entire @entity3 ( @entity3 ) three-dimensional activation and entrainment mapping were evaluated during @entity1 in 18 @entity0 using CARTO sound. RESULTS: The CT was clearly visualized by ICE and the local electrograms along the CT were single potentials in all the @entity0 . The CT was recognized as the truly active anterior pathway based on entrainment mapping in all @entity0 . Double potentials were recorded along the PMRA. Entire @entity3 entrainment mapping could be performed in 16 @entity0 . The reentry circuits were separated into three passages. The first was around the tricuspid annulus (TA), the second the anterior superior vena cava ( @entity2 ; @entity1 waves passed between the anterior @entity2 and @entity3 appendage), and the last the posterior @entity2 (between the posterior @entity2 and upper limit of the PMRA). All three of these passages were active in four, around the TA and anterior @entity2 in eight, around the TA and posterior @entity2 in three, and around only the anterior @entity2 in one @entity0 . CONCLUSIONS: The CT functions as the anterior pathway of typical @entity1 , and the posterior block line was located along the PMRA. Dual or triple circuits were recognized in the majority of @entity1 @entity0 .

title: Crista Terminalis as the Anterior Pathway of Typical XXXX : Insights from Entrainment Map with 3D Intracardiac Ultrasound.

answer: @entity1


abstract: UNASSIGNED: @entity6 ( @entity7 ) is a major @entity8 component of green tea (Camellia sinensis) and demonstrates anti-oxidant, anticancer and anti-inflammatory properties. @entity7 has been shown to protect @entity4 ( @entity4 ) against oxidative stress-induced cell death. The pathogenesis of diseases in the retina is usually initiated by local @entity2 at the @entity4 cell layer, and @entity2 is mostly associated with leukocyte migration and the secretion of pro-inflammatory cytokines. Whether @entity7 can modulate the cytokine-induced inflammatory response of @entity4 , particularly leukocyte migration, has not been clearly elucidated, and was therefore the objective of this study. @entity0 cells were cultured with different concentrations of @entity3 in the presence or absence of @entity7 to different time points. Intracellular reactive @entity1 species (ROS) levels were determined. @entity5 and phosphor-NF-kB and IkB expression were determined by Western blot analysis. Phosphor-NF-kB nuclear translocation and monocyte- @entity4 adhesion were investigated using immunofluorescence confocal laser scanning microscopy. Scanning electron microscopy (SEM) was carried out to further determine the ultrastructure of monocyte- @entity4 adhesion. The results demonstrated that @entity3 modulated inflammatory effects in ARPE-19 by induction of ROS and up-regulation of @entity5 expression. Moreover, @entity3 -induced phosphor-NF-kB nuclear translocation, increased phosphor-NF-kB expression and IkB degradation, and increased the degree of monocyte- @entity4 adhesion. Pretreating the cells with @entity7 ameliorated the inflammatory effects of @entity3 . The results indicated that @entity7 significantly exerts anti-inflammatory effects in @entity0 cells, partly as a suppressor of @entity3 signaling and that the inhibition was mediated via the NF-kB pathway.

title: Green Tea @entity8 @entity6 Attenuates XXXX -Induced Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Retinal Pigment Epithelial Cells.

answer: @entity3


abstract: UNASSIGNED: @entity6 ( @entity7 ) is a major @entity8 component of green tea (Camellia sinensis) and demonstrates anti-oxidant, anticancer and anti-inflammatory properties. @entity7 has been shown to protect @entity4 ( @entity4 ) against oxidative stress-induced cell death. The pathogenesis of diseases in the retina is usually initiated by local @entity2 at the @entity4 cell layer, and @entity2 is mostly associated with leukocyte migration and the secretion of pro-inflammatory cytokines. Whether @entity7 can modulate the cytokine-induced inflammatory response of @entity4 , particularly leukocyte migration, has not been clearly elucidated, and was therefore the objective of this study. @entity0 cells were cultured with different concentrations of @entity3 in the presence or absence of @entity7 to different time points. Intracellular reactive @entity1 species (ROS) levels were determined. @entity5 and phosphor-NF-kB and IkB expression were determined by Western blot analysis. Phosphor-NF-kB nuclear translocation and monocyte- @entity4 adhesion were investigated using immunofluorescence confocal laser scanning microscopy. Scanning electron microscopy (SEM) was carried out to further determine the ultrastructure of monocyte- @entity4 adhesion. The results demonstrated that @entity3 modulated inflammatory effects in ARPE-19 by induction of ROS and up-regulation of @entity5 expression. Moreover, @entity3 -induced phosphor-NF-kB nuclear translocation, increased phosphor-NF-kB expression and IkB degradation, and increased the degree of monocyte- @entity4 adhesion. Pretreating the cells with @entity7 ameliorated the inflammatory effects of @entity3 . The results indicated that @entity7 significantly exerts anti-inflammatory effects in @entity0 cells, partly as a suppressor of @entity3 signaling and that the inhibition was mediated via the NF-kB pathway.

title: Green Tea XXXX @entity6 Attenuates @entity3 -Induced Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Retinal Pigment Epithelial Cells.

answer: @entity8


abstract: UNASSIGNED: @entity6 ( @entity7 ) is a major @entity8 component of green tea (Camellia sinensis) and demonstrates anti-oxidant, anticancer and anti-inflammatory properties. @entity7 has been shown to protect @entity4 ( @entity4 ) against oxidative stress-induced cell death. The pathogenesis of diseases in the retina is usually initiated by local @entity2 at the @entity4 cell layer, and @entity2 is mostly associated with leukocyte migration and the secretion of pro-inflammatory cytokines. Whether @entity7 can modulate the cytokine-induced inflammatory response of @entity4 , particularly leukocyte migration, has not been clearly elucidated, and was therefore the objective of this study. @entity0 cells were cultured with different concentrations of @entity3 in the presence or absence of @entity7 to different time points. Intracellular reactive @entity1 species (ROS) levels were determined. @entity5 and phosphor-NF-kB and IkB expression were determined by Western blot analysis. Phosphor-NF-kB nuclear translocation and monocyte- @entity4 adhesion were investigated using immunofluorescence confocal laser scanning microscopy. Scanning electron microscopy (SEM) was carried out to further determine the ultrastructure of monocyte- @entity4 adhesion. The results demonstrated that @entity3 modulated inflammatory effects in ARPE-19 by induction of ROS and up-regulation of @entity5 expression. Moreover, @entity3 -induced phosphor-NF-kB nuclear translocation, increased phosphor-NF-kB expression and IkB degradation, and increased the degree of monocyte- @entity4 adhesion. Pretreating the cells with @entity7 ameliorated the inflammatory effects of @entity3 . The results indicated that @entity7 significantly exerts anti-inflammatory effects in @entity0 cells, partly as a suppressor of @entity3 signaling and that the inhibition was mediated via the NF-kB pathway.

title: Green Tea @entity8 XXXX Attenuates @entity3 -Induced Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Retinal Pigment Epithelial Cells.

answer: @entity6


abstract: AIM: This study investigates the colonization rate of @entity1 in the gastrointestinal tracts of @entity0 living in southern China and applies a modified method for the isolation and subtyping of A.  muciniphila strains from faecal samples. METHODS AND RESULTS: Fresh faecal samples were collected and bacterial DNA was extracted from these samples for real-time PCR analysis. Strains were separated using a culture-dependent sPCR-directed method and classified using an enterobacterial repetitive intergenic consensus (ERIC-PCR) DNA fingerprinting method. The colonization rate for the sample population from southern China was 51  74%. We isolated 22 strains from @entity0 faeces. The results revealed that all strains were identifiable as A.  muciniphila with 99-100% identity to the type-strain @entity1 . ERIC-PCR resulted in grouping of the DNA fingerprints showed that 12 distinct clusters were distinguished with a delineation level of 100%. CONCLUSIONS: Southern China has a high rate of A.  muciniphila colonization and over 12 different subtype strains reside in faecal samples. SIGNIFICANCE AND IMPACT OF THE STUDY: @entity1 has a beneficial role in @entity0 gastrointestinal tract. These studies provide a better understanding of A.  muciniphila and details of its colonization in the @entity0 gastrointestinal tract.

title: Different subtype strains of XXXX abundantly colonize in southern China.

answer: @entity1


abstract: BACKGROUND: The American College of Emergency Physicians and the American Society of Clinical Oncology recommend early palliative care consultation for @entity0 with advanced, life-limiting illnesses, such as @entity1 . OBJECTIVES: The objectives were to assess the process of early referral from the emergency department (ED) to palliative care for @entity0 with advanced, incurable @entity1 as part of a randomized controlled trial and to compare the proportion and timing of consultation to a care as usual group. METHODS: A single-blind randomized controlled trial (ClinicalTrials.gov ID NCT01358110) compared early, ED-based referrals to palliative care for @entity0 admitted with advanced, incurable @entity1 to physician-driven consultation (i.e., care as usual). @entity0 had to speak English or Spanish and have no history of palliative care consultation. They were randomized via @entity2 randomization to the intervention or control group. Each intervention subject was referred by a research staff member to the palliative care team for consultation. The usual care group received palliative care only if requested by the admitting physician. Analysis was based on intention to treat. A chart review was performed to assess proportion and timing of palliative care consults during the index admission, defined as: 1) completed palliative care consult documented in the chart and 2) days from admission to palliative care consult. RESULTS: A total of 134 @entity0 were enrolled and randomized. For @entity0 in the intervention group, 88% (60 of 68) had documented palliative care consultations during their index admissions (95% confidence interval [CI]  =  80.5 to 95.5), compared to 18% (12 of 66) in the control group (95% CI  =  8.8 to 27.5; p < 0.01). The 60 intervention @entity0 received palliative care consultations on average 1.48  days from admission (95% CI  =  1.19 to 1.76), compared to 2.9  days from admission in the 12 control @entity0 (95% CI  =  1.03 to 4.79; p  =  0.15). CONCLUSIONS: This study documented a low baseline rate of palliative care involvement as part of usual care in @entity0 with @entity1 being admitted from the ED. Early referral to palliative care in the context of a research study significantly increased the likelihood that @entity0 received a consult, thus meriting further investigation of how to generalize this approach.

title: Emergency Department-triggered Palliative Care in XXXX : Proof of Concept.

answer: @entity1


abstract: Wnt antagonism has been linked to @entity1 and intraocular pressure regulation, as has increased stiffness of @entity0 trabecular meshwork (HTM) tissue. We have shown culturing HTM cells on substrates that mimic the elevated stiffness of glaucomatous tissue leads to elevated expression of the Wnt antagonist @entity4 ( @entity4 ), suggesting a linkage between @entity4 and HTM mechanobiology. In this study, we document biomechanical consequences of Wnt antagonism on HTM cells. Cells were treated with the Wnt antagonists ( @entity4 , @entity5 , and LGK-974) for 8 days and allowed to recover for 4 days. After recovery, intrinsic cell stiffness and activation of the Wnt pathway via @entity3 staining and blotting were assayed. Basal cell stiffness values were 3.71      0.37, 4.33      3.07, and 3.07      kPa (median      S.D.) for cells derived from 3 donors. Cell stiffness increased after 0.25   g/mL (4.32      5.12, 8.86      8.51, 4.84      3.15  kPa) and 0.5   g/mL (16.75      5.59, 13.18      7.99, and 8.54      5.77  kPa) @entity4 treatment. Stiffening was observed after 10   M @entity5 (10.72      5.63 and 6.57      5.53  kPa) as well as LGK-974 (9.60      7.41 and 11.40      9.24  kPa) treatment compared with controls (3.79      1.01 and 5.16      2.14  kPa). Additionally, Wnt inhibition resulted in decreased @entity3 staining and increased phosphorylation at @entity2 41 after recovery. In conclusion, this work demonstrates a causal relationship between Wnt inhibition and cell stiffening. Additionally, these findings suggest transient Wnt inhibition resulted in durable modulation of the mechanical phenotype of HTM cells. When placed in context with previous results, these findings provide a causal link between Wnt antagonism and cell stiffness and suggest a feedback loop contributing to @entity1 progression.

title: Wnt inhibition induces persistent increases in intrinsic stiffness of XXXX trabecular meshwork cells.

answer: @entity0


abstract: BACKGROUND: Mutations in the nucleophosmin ( @entity2 ) gene have been used as molecular biomarkers for prognostication of @entity0 with adult @entity1 ( @entity1 ). METHODS: We designed a rapid and sensitive method using the allele-specific-refractory mutation system-polymerase chain reaction (ARMS-PCR) to detect the most common mutations of @entity2 gene, which are mostly four base pair insertions and compared its efficacy with direct sequencing and capillary electrophoresis which served as the gold standards. RESULTS: The incidence of mutation was 22% (33% of @entity0 with normal karyotypes had mutation compared with 16% of @entity0 with abnormal karyotypes) based on the results obtained with capillary electrophoresis analysis and direct sequencing. All of the specimens determined to be mutation-positive by the gold standard tests were also positive by the ARMS-PCR method. Significantly, the ARMS-PCR test also helped determine the mutation status of an extra set of @entity0 who had low call rates on capillary electrophoresis and appeared normal on direct sequencing. DISCUSSION: The low mutation rate in some @entity0 hindered its detection in the gold standard assays because of the interference of the mutation signal by high background noise. The low sensitivity of the gold standard assays for detecting low copy number mutations rates thus increase their risk of producing false negative results that adversely affects prognostication and therapy. Our results suggest that the mutation detection rate of the ARMS-PCR assay is better than existing tests. This is most probably because of the fact that in an ARMS-PCR-based method, the mutated variant is specifically amplified, based on a mutation-specific primer. CONCLUSIONS: We conclude that the high sensitivity of the ARMS-based method together with its rapidity and low expense should make it a suitable choice for clinical laboratories.

title: XXXX Mutation Detection in Acute Myeloid Leukemia: A Method Comparison Study.

answer: @entity2


abstract: BACKGROUND: The prevalence of @entity1 and the female labor participation rate have been rapidly increasing in South Korea. To examine the relationship between these factors, we investigated the association between timing and type of work and @entity1 in the Korean female working population. METHODS: Data collected by the 2008 @entity2 ( @entity2 ) were analyzed using a complex, stratified, multistage, probability cluster sampling method. Descriptive analysis of relevant variables was performed using the chi-square test, and work-related variables by work type were identified using multivariate logistic regression. The relationship between long working hours, night/shift work, and body-mass index in female workers and explanatory, stratifying, and dependent variables and covariates was analyzed using multiple logistic regression models. RESULTS: A total of 42,234 @entity2 @entity0 were eligible for study inclusion. Among both manual and nonmanual workers, working less than 40 (adjusted odds ratio [aOR] 1.18, 95% confidence interval [CI] 1.07-1.31 and aOR 1.29; 95% CI 1.09-0.52, respectively) or more than 60 (aOR 1.18, 95% CI 1.06-1.30 and aOR 1.28, 95% CI 1.04-1.57, respectively) hours per week was significantly associated with @entity1 after controlling for covariates. However, working type (day or night/shift) was significantly associated with @entity1 only in nonmanual workers (aOR 1.20, 95% CI 1.01-1.42). When we controlled working type in the model, manual workers who work more than 60 hours show higher likelihood of being @entity1 ( @entity3 , 95% CI 1.02-1.18). CONCLUSION: Working fewer (<40) or more than (>60) hours per week is significantly associated with @entity1 in the Korean female working population, regardless of the type of work. The type of work (day vs. night/shift work) was significantly associated with @entity1 only in only nonmanual workers.

title: Do Working Hours and Type of Work Affect Obesity in South Korean Female Workers? Analysis of the Korean XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity3 from @entity5 or esophago-gastric varices are life threatening medical conditions which require immediate endoscopic therapy. Despite successful endoscopic hemostasis, there is a significant risk of rebleeding often requiring close surveillance of these @entity0 in the intensive care unit (ICU). Any time delay to recognize @entity4 may lead to a high @entity1 and increases the risk of @entity2 . A novel telemetric real-time @entity4 sensor can help indicate blood in the stomach: the sensor is swallowed to detect active @entity4 or is anchored endoscopically on the gastrointestinal wall close to the potential @entity4 source. By telemetric communication with an extra-corporeal receiver, information about the @entity4 status is displayed. In this study the novel sensor, which measures characteristic optical properties of blood, has been evaluated in an ex-vivo setting to assess its clinical applicability and usability. @entity0 venous blood of different concentrations, various fluids, and liquid food were tested. The LED-based sensor was able to reliably distinguish between concentrated blood and other liquids, especially red-colored fluids. In addition, the spectrometric quality of the small sensor (size: 6.5mm in diameter, 25.5mm in length) was comparable to a much larger and technically more complex laboratory spectrophotometer. The experimental data confirm the capability of a miniaturized sensor to identify concentrated blood, which could help in the very near future the detection of upper @entity3 and to survey high-risk @entity0 for rebleeding.

title: Telemetric real-time sensor for the detection of XXXX .

answer: @entity3


abstract: BACKGROUND: Early/intensive mobilization may improve functional recovery after @entity1 but it is not clear which kind of "mobilization" is more effective. Proprioceptive neuromuscular facilitation (PNF) and @entity2 ( @entity2 ) are widespread applied in post- @entity1 rehabilitation but their efficacy and safety have not been systematically investigated. AIM: To compare PNF and @entity2 methods in a two different time setting (early versus standard approach) in order to evaluate different role of time and techniques in functional recovery after acute @entity4 . DESIGN: We designed a prospectical multicenter blinded interventional study of early versus standard approach with two different methods by means of both PNF and @entity2 . SETTING: A discrete @entity1 -dedicated area for out-of-thrombolysis @entity0 , connected with two different @entity1 centres in two different catchment areas. POPULATION: Three hundred and forty consecutive @entity1 @entity0 with first ever sub-cortical @entity4 in the mean cerebral artery (MCA) territory and contralateral @entity5 admitted within 6 and 24 hours from symptoms onset. METHODS: All @entity0 were randomly assigned by means of a computer generated randomization sequence in blocks of 4 to one to the 4 interventional groups: early versus delayed rehabilitation programs with Kabat's schemes or Perfetti's technique. @entity0 in both delayed group underwent to a standard protocol in the acute phase. PRIMARY OUTCOME: disability at 3-12 months. Disability measures: modified Rankin Score and Barthel Index. Safety outcome: immobility-related adverse events. SECONDARY OUTCOME MEASURES: Six-Minute Walking Test, Motricity Index, Mini-Mental State Examination, Beck @entity3 Inventory. RESULTS: Disability was not different between groups at 3 months but Barthel Index significantly changed between early versus delayed groups at 12 months (P=0.01). Six-Minute Walking Test (P=0.01) and Motricity Index in both upper (P=0.01) and lower limbs (P=0.001) increased in early versus delayed groups regardless rehabilitation schedule. CONCLUSIONS: A time-dependent effect of rehabilitation on post @entity1 motor recovery was observed, particularly in lower limb improvement. According to our results, rehabilitation technique seems not to affect long term motor recovery. CLINICAL REHABILITATION IMPACT: These results show a significant effect of time but not of technique that may impact the decision making in the acute phase of care.

title: Early versus delayed rehabilitation treatment in hemiplegic @entity0 with @entity4 : proprioceptive or XXXX ?

answer: @entity2


abstract: BACKGROUND: Early/intensive mobilization may improve functional recovery after @entity1 but it is not clear which kind of "mobilization" is more effective. Proprioceptive neuromuscular facilitation (PNF) and @entity2 ( @entity2 ) are widespread applied in post- @entity1 rehabilitation but their efficacy and safety have not been systematically investigated. AIM: To compare PNF and @entity2 methods in a two different time setting (early versus standard approach) in order to evaluate different role of time and techniques in functional recovery after acute @entity4 . DESIGN: We designed a prospectical multicenter blinded interventional study of early versus standard approach with two different methods by means of both PNF and @entity2 . SETTING: A discrete @entity1 -dedicated area for out-of-thrombolysis @entity0 , connected with two different @entity1 centres in two different catchment areas. POPULATION: Three hundred and forty consecutive @entity1 @entity0 with first ever sub-cortical @entity4 in the mean cerebral artery (MCA) territory and contralateral @entity5 admitted within 6 and 24 hours from symptoms onset. METHODS: All @entity0 were randomly assigned by means of a computer generated randomization sequence in blocks of 4 to one to the 4 interventional groups: early versus delayed rehabilitation programs with Kabat's schemes or Perfetti's technique. @entity0 in both delayed group underwent to a standard protocol in the acute phase. PRIMARY OUTCOME: disability at 3-12 months. Disability measures: modified Rankin Score and Barthel Index. Safety outcome: immobility-related adverse events. SECONDARY OUTCOME MEASURES: Six-Minute Walking Test, Motricity Index, Mini-Mental State Examination, Beck @entity3 Inventory. RESULTS: Disability was not different between groups at 3 months but Barthel Index significantly changed between early versus delayed groups at 12 months (P=0.01). Six-Minute Walking Test (P=0.01) and Motricity Index in both upper (P=0.01) and lower limbs (P=0.001) increased in early versus delayed groups regardless rehabilitation schedule. CONCLUSIONS: A time-dependent effect of rehabilitation on post @entity1 motor recovery was observed, particularly in lower limb improvement. According to our results, rehabilitation technique seems not to affect long term motor recovery. CLINICAL REHABILITATION IMPACT: These results show a significant effect of time but not of technique that may impact the decision making in the acute phase of care.

title: Early versus delayed rehabilitation treatment in hemiplegic @entity0 with XXXX : proprioceptive or @entity2 ?

answer: @entity4


abstract: BACKGROUND: Early/intensive mobilization may improve functional recovery after @entity1 but it is not clear which kind of "mobilization" is more effective. Proprioceptive neuromuscular facilitation (PNF) and @entity2 ( @entity2 ) are widespread applied in post- @entity1 rehabilitation but their efficacy and safety have not been systematically investigated. AIM: To compare PNF and @entity2 methods in a two different time setting (early versus standard approach) in order to evaluate different role of time and techniques in functional recovery after acute @entity4 . DESIGN: We designed a prospectical multicenter blinded interventional study of early versus standard approach with two different methods by means of both PNF and @entity2 . SETTING: A discrete @entity1 -dedicated area for out-of-thrombolysis @entity0 , connected with two different @entity1 centres in two different catchment areas. POPULATION: Three hundred and forty consecutive @entity1 @entity0 with first ever sub-cortical @entity4 in the mean cerebral artery (MCA) territory and contralateral @entity5 admitted within 6 and 24 hours from symptoms onset. METHODS: All @entity0 were randomly assigned by means of a computer generated randomization sequence in blocks of 4 to one to the 4 interventional groups: early versus delayed rehabilitation programs with Kabat's schemes or Perfetti's technique. @entity0 in both delayed group underwent to a standard protocol in the acute phase. PRIMARY OUTCOME: disability at 3-12 months. Disability measures: modified Rankin Score and Barthel Index. Safety outcome: immobility-related adverse events. SECONDARY OUTCOME MEASURES: Six-Minute Walking Test, Motricity Index, Mini-Mental State Examination, Beck @entity3 Inventory. RESULTS: Disability was not different between groups at 3 months but Barthel Index significantly changed between early versus delayed groups at 12 months (P=0.01). Six-Minute Walking Test (P=0.01) and Motricity Index in both upper (P=0.01) and lower limbs (P=0.001) increased in early versus delayed groups regardless rehabilitation schedule. CONCLUSIONS: A time-dependent effect of rehabilitation on post @entity1 motor recovery was observed, particularly in lower limb improvement. According to our results, rehabilitation technique seems not to affect long term motor recovery. CLINICAL REHABILITATION IMPACT: These results show a significant effect of time but not of technique that may impact the decision making in the acute phase of care.

title: Early versus delayed rehabilitation treatment in hemiplegic XXXX with @entity4 : proprioceptive or @entity2 ?

answer: @entity0


abstract: Ruminants remain productive during the @entity4 or early lactation by evoking metabolic adaptations sparing available energy and nutrients (e.g. higher metabolic efficiency and induction of insulin resistance). A deficit in central leptin signaling triggers these adaptations in rodents but whether it does in ruminants remains unclear. To address this issue, five mature ewes were implanted with intracerebroventricular (ICV) cannula in the third ventricle. They were used in two experiments with an ovine leptin antagonist (OLA) when well-conditioned (average body condition score of 3.7 on a 5 point scale). The first experiment tested the ability of OLA to antagonize leptin under in vivo conditions. Ewes received continuous ICV infusion of artificial cerebrospinal fluid (aCSF), ovine leptin (4   g/h) or the combination of ovine leptin (4   g/h) and its mutant version OLA (40   g/h) for 48 h. Dry matter intake (DMI) was measured every day and blood samples were collected on the last day of infusion. ICV infusion of leptin reduced DMI by 24% (P < 0.05), and this effect was completely abolished by OLA co-infusion. A second experiment tested whether a reduction in endogenous leptin signaling in the brain triggers metabolic adaptations. This involved continuous ICV infusions of aCSF or OLA alone (40   g/h) for 4 consecutive days. The infusion of OLA did not alter voluntary DMI over the treatment period or on any individual day. OLA did not affect plasma variables indicative of insulin action ( @entity0 , non-esterified @entity3 , insulin and the disposition of plasma @entity0 during an insulin tolerance test) or plasma @entity1 , but tended to reduce plasma @entity5 and @entity6 (P < 0.07). Overall, these data show that a reduction of central leptin signaling has little impact on insulin action in well-conditioned mature @entity2 . They also raise the possibility that reduced central leptin signaling plays a role in controlling @entity7 production.

title: Insensitivity of well-conditioned mature XXXX to central administration of a leptin receptor antagonist.

answer: @entity2


abstract: AIMS: Psychopathology has been studied in @entity0 with @entity1 or @entity1 in the context of diagnosis and treatment. Unfortunately, most PNES studies include few males and do not consider possible gender differences, making findings less generalizable to males with PNES. In this study we specifically compare males with PNES to females with PNES and to males with @entity1 . METHODS: Males with PNES (n=58), males with @entity1 (n=86), females with PNES (n=147), and females with @entity4 (n=142) were evaluated on an inpatient @entity1 monitoring unit. Self-reported objective measures of psychopathology, demographics, and PNES @entity3 semiology were compared. RESULTS: Personality Assessment Inventory profiles revealed marked differences, particularly in somatic symptoms, between PNES and @entity1 . Females with PNES had higher levels of physiological @entity2 but lower antisocial features. Males with PNES who had clinically significant elevations on the somatic complaints scale were much more likely to have motor @entity3 while females with PNES classified similarly were equally likely to have either motor or non-motor events. CONCLUSION: Gender difference in PNES @entity3 semiology was associated with whether or not clinically significant somatic symptoms were present; males with elevated somatic symptoms were much more likely to have motor PNES. However, we did not find evidence of greater psychopathology in males with PNES compared to females with PNES. Gender differences in the behavioral manifestation of PNES in the context of presence or absence of somatization may have implications for diagnosis and treatment.

title: XXXX semiology in males with psychogenic @entity3 is associated with somatic complaints.

answer: @entity3


abstract: AIMS: Psychopathology has been studied in @entity0 with @entity1 or @entity1 in the context of diagnosis and treatment. Unfortunately, most PNES studies include few males and do not consider possible gender differences, making findings less generalizable to males with PNES. In this study we specifically compare males with PNES to females with PNES and to males with @entity1 . METHODS: Males with PNES (n=58), males with @entity1 (n=86), females with PNES (n=147), and females with @entity4 (n=142) were evaluated on an inpatient @entity1 monitoring unit. Self-reported objective measures of psychopathology, demographics, and PNES @entity3 semiology were compared. RESULTS: Personality Assessment Inventory profiles revealed marked differences, particularly in somatic symptoms, between PNES and @entity1 . Females with PNES had higher levels of physiological @entity2 but lower antisocial features. Males with PNES who had clinically significant elevations on the somatic complaints scale were much more likely to have motor @entity3 while females with PNES classified similarly were equally likely to have either motor or non-motor events. CONCLUSION: Gender difference in PNES @entity3 semiology was associated with whether or not clinically significant somatic symptoms were present; males with elevated somatic symptoms were much more likely to have motor PNES. However, we did not find evidence of greater psychopathology in males with PNES compared to females with PNES. Gender differences in the behavioral manifestation of PNES in the context of presence or absence of somatization may have implications for diagnosis and treatment.

title: @entity3 semiology in males with psychogenic XXXX is associated with somatic complaints.

answer: @entity3


abstract: INTRODUCTION: Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying @entity0 as to whether they will respond or not to a given treatment before prescription is not only essential to optimise treatment outcome but also to lessen the economic burden that such drugs can have on healthcare resources. In @entity1 ( @entity1 ), there is of yet no genetic/genomic biomarker which can accurately predict response to @entity2 inhibitor biologics prior to treatment, despite much interest in this area. Multiple studies have reported findings on potential candidate genes; however, due to relatively small sample sizes or lack of sufficient validation, results have been disappointingly inconsistent. The aim of this research was to further explore the predictive value of a previously reported association between @entity3 expression and response to the @entity2 inhibitor biologics, adalimumab and etanercept. METHODS: Real-time qPCR was performed using whole blood RNA samples obtained from seventy-five @entity1 @entity0 about to commence treatment with a @entity2 inhibitor biologic drug, whose response status was determined at 3-month follow-up using the EULAR classification criteria. Relative quantification of @entity3 using the comparative CT method outputted differential expression between good-responders and non-responders as a fold-change. RESULTS: Relative expression of @entity3 in @entity0 receiving @entity2 inhibitor biologics yielded a decrease of 1.025 fold in good-responders as compared to non-responders (p-value = 0.36). Upon stratification of @entity0 dependent upon the specific drug administered, adalimumab or etanercept, similar findings to the full cohort were observed, decreases of 1.015 (p-value = 0.33) and 1.032 fold (p-value = 0.13) in good-responders compared to non-responders, respectively. CONCLUSION: The results from this study reveal that @entity3 expression does not correlate with response to @entity2 inhibitor biologics when tested for within pre-treatment whole blood samples of @entity1 @entity0 .

title: Investigating @entity3 expression as a potential genomic biomarker of response to XXXX inhibitor biologics in whole blood @entity1 samples.

answer: @entity2


abstract: INTRODUCTION: Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying @entity0 as to whether they will respond or not to a given treatment before prescription is not only essential to optimise treatment outcome but also to lessen the economic burden that such drugs can have on healthcare resources. In @entity1 ( @entity1 ), there is of yet no genetic/genomic biomarker which can accurately predict response to @entity2 inhibitor biologics prior to treatment, despite much interest in this area. Multiple studies have reported findings on potential candidate genes; however, due to relatively small sample sizes or lack of sufficient validation, results have been disappointingly inconsistent. The aim of this research was to further explore the predictive value of a previously reported association between @entity3 expression and response to the @entity2 inhibitor biologics, adalimumab and etanercept. METHODS: Real-time qPCR was performed using whole blood RNA samples obtained from seventy-five @entity1 @entity0 about to commence treatment with a @entity2 inhibitor biologic drug, whose response status was determined at 3-month follow-up using the EULAR classification criteria. Relative quantification of @entity3 using the comparative CT method outputted differential expression between good-responders and non-responders as a fold-change. RESULTS: Relative expression of @entity3 in @entity0 receiving @entity2 inhibitor biologics yielded a decrease of 1.025 fold in good-responders as compared to non-responders (p-value = 0.36). Upon stratification of @entity0 dependent upon the specific drug administered, adalimumab or etanercept, similar findings to the full cohort were observed, decreases of 1.015 (p-value = 0.33) and 1.032 fold (p-value = 0.13) in good-responders compared to non-responders, respectively. CONCLUSION: The results from this study reveal that @entity3 expression does not correlate with response to @entity2 inhibitor biologics when tested for within pre-treatment whole blood samples of @entity1 @entity0 .

title: Investigating @entity3 expression as a potential genomic biomarker of response to @entity2 inhibitor biologics in whole blood XXXX samples.

answer: @entity1


abstract: INTRODUCTION: Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying @entity0 as to whether they will respond or not to a given treatment before prescription is not only essential to optimise treatment outcome but also to lessen the economic burden that such drugs can have on healthcare resources. In @entity1 ( @entity1 ), there is of yet no genetic/genomic biomarker which can accurately predict response to @entity2 inhibitor biologics prior to treatment, despite much interest in this area. Multiple studies have reported findings on potential candidate genes; however, due to relatively small sample sizes or lack of sufficient validation, results have been disappointingly inconsistent. The aim of this research was to further explore the predictive value of a previously reported association between @entity3 expression and response to the @entity2 inhibitor biologics, adalimumab and etanercept. METHODS: Real-time qPCR was performed using whole blood RNA samples obtained from seventy-five @entity1 @entity0 about to commence treatment with a @entity2 inhibitor biologic drug, whose response status was determined at 3-month follow-up using the EULAR classification criteria. Relative quantification of @entity3 using the comparative CT method outputted differential expression between good-responders and non-responders as a fold-change. RESULTS: Relative expression of @entity3 in @entity0 receiving @entity2 inhibitor biologics yielded a decrease of 1.025 fold in good-responders as compared to non-responders (p-value = 0.36). Upon stratification of @entity0 dependent upon the specific drug administered, adalimumab or etanercept, similar findings to the full cohort were observed, decreases of 1.015 (p-value = 0.33) and 1.032 fold (p-value = 0.13) in good-responders compared to non-responders, respectively. CONCLUSION: The results from this study reveal that @entity3 expression does not correlate with response to @entity2 inhibitor biologics when tested for within pre-treatment whole blood samples of @entity1 @entity0 .

title: Investigating XXXX expression as a potential genomic biomarker of response to @entity2 inhibitor biologics in whole blood @entity1 samples.

answer: @entity3


abstract: Serial assessment of cardiac function by radionuclide ejection fraction (EF), using a "first-pass" technique, was performed prior to each dose in 292 @entity0 receiving @entity2 . Detailed analysis was undertaken in 98 @entity0 , consisting of all 91 @entity0 who had received greater than 200 mg/m2 and seven with risk factors (RFs) who had received between 100 and 200 mg/m2. Thirty-two @entity0 had RFs and 66 had no risk factors (NRFs). RFs were: (a) @entity1 , (b) mediastinal irradiation within 6 months of starting @entity2 treatment, and (c) total @entity2 dose greater than 550 mg/m2. The criteria for discontinuing @entity2 were EF less than 0.40 in @entity5 @entity0 or less than 0.35 in @entity6 @entity0 or decrease in EF of greater than or equal to 0.14 over three successive readings. In the @entity6 group, no @entity0 met these criteria nor did any develop @entity3 . In the @entity5 group, discontinuation was indicated in eight @entity0 : two stopped receiving @entity2 at total doses of 730 mg/m2 and 680 mg/m2, respectively, and it was discontinued in the other six at total doses ranging from 120 to 420 mg/m2. Prior to the first dose of @entity2 , all @entity0 should have a baseline EF and assessment of RFs. An EF study is required before each subsequent dose in @entity0 with RFs or with initial EF less than 0.45, but in the remaining @entity0 , serial studies are not required until there is a cumulative dose of 450 mg/m2. Use of these guidelines and our criteria for discontinuation may prevent development of @entity2 @entity4 .

title: Radionuclide ejection fraction in @entity2 XXXX .

answer: @entity4


abstract: Serial assessment of cardiac function by radionuclide ejection fraction (EF), using a "first-pass" technique, was performed prior to each dose in 292 @entity0 receiving @entity2 . Detailed analysis was undertaken in 98 @entity0 , consisting of all 91 @entity0 who had received greater than 200 mg/m2 and seven with risk factors (RFs) who had received between 100 and 200 mg/m2. Thirty-two @entity0 had RFs and 66 had no risk factors (NRFs). RFs were: (a) @entity1 , (b) mediastinal irradiation within 6 months of starting @entity2 treatment, and (c) total @entity2 dose greater than 550 mg/m2. The criteria for discontinuing @entity2 were EF less than 0.40 in @entity5 @entity0 or less than 0.35 in @entity6 @entity0 or decrease in EF of greater than or equal to 0.14 over three successive readings. In the @entity6 group, no @entity0 met these criteria nor did any develop @entity3 . In the @entity5 group, discontinuation was indicated in eight @entity0 : two stopped receiving @entity2 at total doses of 730 mg/m2 and 680 mg/m2, respectively, and it was discontinued in the other six at total doses ranging from 120 to 420 mg/m2. Prior to the first dose of @entity2 , all @entity0 should have a baseline EF and assessment of RFs. An EF study is required before each subsequent dose in @entity0 with RFs or with initial EF less than 0.45, but in the remaining @entity0 , serial studies are not required until there is a cumulative dose of 450 mg/m2. Use of these guidelines and our criteria for discontinuation may prevent development of @entity2 @entity4 .

title: Radionuclide ejection fraction in XXXX @entity4 .

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ) are commonly used as adjunctive hormone treatment for early @entity0 @entity1 . The major side effect of @entity5 is @entity4 , which affects adherence. Previous reviews suggested that acupuncture is effective in the management of @entity2 . The aim of this review is to evaluate the effects of acupuncture on @entity4 caused by @entity5 . METHODS: This article examined @entity3 ( @entity3 ) measuring the effects of acupuncture on joint symptoms caused by @entity5 within 8 medical databases till May 2014. The quality of the articles was evaluated according to the Cochrane risk of bias (ROB) tool. RESULTS: Four @entity3 were identified in medical journals. Two studies were conducted with manual acupuncture and 2 studies were electroacupuncture. The range of sample size was between 32 and 67. One RCT showed significant improvement in the acupuncture group compared with the sham control group and another RCT showed a statistical difference between the electroacupuncture and waitlist group. The other 2 studies showed no statistical differences between control and acupuncture groups. Two studies conducted blood analysis to elucidate the mechanism of efficacy of acupuncture for @entity4 . The 2 positive studies had a lower ROB and 2 studies had a high ROB. CONCLUSIONS: The systematic review suggests that acupuncture has potential benefits to improve @entity4 caused by @entity5 . However, further trials of adequate sample size, appropriate control group, and longer follow-up are necessary to investigate the efficacy of acupuncture in AI-induced @entity4 .

title: Acupuncture for Aromatase Inhibitor-Induced XXXX : A Systematic Review.

answer: @entity4


abstract: INTRODUCTION: @entity7 , a radiopharmaceutical widely used in the assessment of myocardial perfusion, can be used as an indicator of @entity3 due to its oncophilic character. The aim of this study was to establish the usefulness of performing additional examinations of radiotracer uptake in the thyroid gland during standard stress scintigraphy with sestamibi in order to identify @entity3 . MATERIAL AND METHODS: After a retrospective evaluation of 330 consecutive myocardial perfusion scintigraphies performed in our hospital during one year, 41 @entity0 with a focal accumulation of @entity7 in the thyroid were enrolled in the study. The @entity0 underwent clinical examinations, including thyroid ultrasonography and TSH, fT4, fT3, @entity6 , TRAB, calcitonin, and @entity2 levels. Based on the thyroid ultrasounds, 21 @entity0 were referred for fine-needle aspiration biopsy of the thyroid. RESULTS: An abnormal accumulation of radiotracer in the thyroid was found in 41(12.4%) of 330 @entity0 who underwent stress cardiac scintigraphy. Thirteen (31.7%) of those @entity0 had multinodular euthyroid goitres, 12 (29.2%) had a single thyroid nodule (including two autonomous nodules), 11 (26.8%) had @entity4 , and one (2.4%) had @entity5 . In 12 (29.2%) with thyroid tracer uptake there was no thyroid pathology. CONCLUSIONS: Additional evaluation of radiotracer uptake in the thyroid during standard myocardial perfusion scintigraphy is a valuable tool in the detection of @entity3 . The additional or parallel evaluation of radiotracer uptake in the thyroid should be considered during every @entity1 . (Endokrynol Pol 2015; 66 (6): 521-525).

title: Incidentally recognised thyroid focal uptake of XXXX during stress myocardial perfusion scintigraphy.

answer: @entity7


abstract: BACKGROUND: In @entity2 , clotting can either stabilise the @entity3 sac via @entity3 , or it can have a detrimental effect by giving rise to @entity1 . OBJECTIVE: The work presented in this study details the development of an in silico model that combines, all the salient, clinically relevant features of @entity2 clotting. A comprehensive computational model of clotting that accounts for biochemical complexity coupled with three-dimensional haemodynamics in image-derived @entity0 @entity3 , and in the presence of virtually implanted interventional devices is presented. METHODS: The model is developed and presented in two stages. First, a two-dimensional computational model of clotting is presented, for an idealised geometry. This enables verification of the methods with existing, physiological data before the pathological state is considered. This model is used to compare the results predicted by two different underlying biochemical cascades. The two-dimensional model is then extended to image-derived, three-dimensional aneurysmal topologies by incorporating level set methods, demonstrating the potential use of this model. RESULTS AND CONCLUSION: As a proof of concept, comparisons are then made between treated and untreated @entity3 . The prediction of different clotting outcomes for different @entity0 demonstrates that with further development, refinement and validation, this methodology could be used for @entity0 -specific interventional planning. This article is protected by copyright. All rights reserved.

title: Computational modelling of clot development in @entity0 - specific XXXX cases.

answer: @entity2


abstract: BACKGROUND: In @entity2 , clotting can either stabilise the @entity3 sac via @entity3 , or it can have a detrimental effect by giving rise to @entity1 . OBJECTIVE: The work presented in this study details the development of an in silico model that combines, all the salient, clinically relevant features of @entity2 clotting. A comprehensive computational model of clotting that accounts for biochemical complexity coupled with three-dimensional haemodynamics in image-derived @entity0 @entity3 , and in the presence of virtually implanted interventional devices is presented. METHODS: The model is developed and presented in two stages. First, a two-dimensional computational model of clotting is presented, for an idealised geometry. This enables verification of the methods with existing, physiological data before the pathological state is considered. This model is used to compare the results predicted by two different underlying biochemical cascades. The two-dimensional model is then extended to image-derived, three-dimensional aneurysmal topologies by incorporating level set methods, demonstrating the potential use of this model. RESULTS AND CONCLUSION: As a proof of concept, comparisons are then made between treated and untreated @entity3 . The prediction of different clotting outcomes for different @entity0 demonstrates that with further development, refinement and validation, this methodology could be used for @entity0 -specific interventional planning. This article is protected by copyright. All rights reserved.

title: Computational modelling of clot development in XXXX - specific @entity2 cases.

answer: @entity0


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity7 involves induction with @entity9 , @entity6 , and @entity3 (BCP) and maintenance with either melphalan and @entity3 (MP), @entity3 , @entity5 , @entity4 , and @entity8 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity2 in the @entity1 MOPC 104E @entity10 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity0 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity2 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity2 . Most of the @entity1 on the PAIV regimen die due to @entity2 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity0 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity0 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity7 maintenance regimen of @entity3 . XXXX , @entity4 , and @entity8 in a @entity1 @entity10 model.

answer: @entity5


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity7 involves induction with @entity9 , @entity6 , and @entity3 (BCP) and maintenance with either melphalan and @entity3 (MP), @entity3 , @entity5 , @entity4 , and @entity8 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity2 in the @entity1 MOPC 104E @entity10 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity0 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity2 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity2 . Most of the @entity1 on the PAIV regimen die due to @entity2 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity0 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity0 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity7 maintenance regimen of @entity3 . @entity5 , @entity4 , and XXXX in a @entity1 @entity10 model.

answer: @entity8


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity7 involves induction with @entity9 , @entity6 , and @entity3 (BCP) and maintenance with either melphalan and @entity3 (MP), @entity3 , @entity5 , @entity4 , and @entity8 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity2 in the @entity1 MOPC 104E @entity10 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity0 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity2 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity2 . Most of the @entity1 on the PAIV regimen die due to @entity2 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity0 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity0 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity7 maintenance regimen of @entity3 . @entity5 , @entity4 , and @entity8 in a @entity1 XXXX model.

answer: @entity10


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity7 involves induction with @entity9 , @entity6 , and @entity3 (BCP) and maintenance with either melphalan and @entity3 (MP), @entity3 , @entity5 , @entity4 , and @entity8 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity2 in the @entity1 MOPC 104E @entity10 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity0 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity2 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity2 . Most of the @entity1 on the PAIV regimen die due to @entity2 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity0 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity0 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity7 maintenance regimen of @entity3 . @entity5 , XXXX , and @entity8 in a @entity1 @entity10 model.

answer: @entity4


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity7 involves induction with @entity9 , @entity6 , and @entity3 (BCP) and maintenance with either melphalan and @entity3 (MP), @entity3 , @entity5 , @entity4 , and @entity8 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity2 in the @entity1 MOPC 104E @entity10 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity0 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity2 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity2 . Most of the @entity1 on the PAIV regimen die due to @entity2 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity0 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity0 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of XXXX maintenance regimen of @entity3 . @entity5 , @entity4 , and @entity8 in a @entity1 @entity10 model.

answer: @entity7


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity7 involves induction with @entity9 , @entity6 , and @entity3 (BCP) and maintenance with either melphalan and @entity3 (MP), @entity3 , @entity5 , @entity4 , and @entity8 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity2 in the @entity1 MOPC 104E @entity10 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity0 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity2 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity2 . Most of the @entity1 on the PAIV regimen die due to @entity2 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity0 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity0 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity7 maintenance regimen of XXXX . @entity5 , @entity4 , and @entity8 in a @entity1 @entity10 model.

answer: @entity3


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity7 involves induction with @entity9 , @entity6 , and @entity3 (BCP) and maintenance with either melphalan and @entity3 (MP), @entity3 , @entity5 , @entity4 , and @entity8 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity2 in the @entity1 MOPC 104E @entity10 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity0 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity2 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity2 . Most of the @entity1 on the PAIV regimen die due to @entity2 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity0 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity0 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity7 maintenance regimen of @entity3 . @entity5 , @entity4 , and @entity8 in a XXXX @entity10 model.

answer: @entity1


abstract: UNASSIGNED: Yolk sac @entity1 are testicular germ-cell @entity1 of the non-seminoma type. In @entity4 , this @entity1 is very rare and to date has only been described three times. In @entity0 males, it usually occurs in @entity0 and @entity0 . Immunohistochemistry provides solid criteria for diagnostics. Especially present pathognomonic Schiller-Duval bodies are helpful for identification. In this report, a 32-day-old Holstein Friesian @entity4 presented with a highly enlarged right testis. Sonographic examination was performed and blood samples were taken to measure @entity3 and @entity2 levels. Furthermore, the testis was surgically removed and macroscopically, histologically, and immunohistochemically examined which lead to the diagnosis of @entity5 . The second testis was descended until the age of nine months and histology revealed impaired spermatogenesis. This report provides the first sonographic images of @entity4 @entity5 as well as the first information about hormone levels in @entity4 with this @entity1 . It also shows the importance to combine anamnesis, histomorphological, and immunohistochemical findings in order to diagnose yolk sac @entity1 when pathognomonic structures are not present.

title: XXXX and impaired spermatogenesis in a Holstein Friesian @entity4 .

answer: @entity5


abstract: UNASSIGNED: Yolk sac @entity1 are testicular germ-cell @entity1 of the non-seminoma type. In @entity4 , this @entity1 is very rare and to date has only been described three times. In @entity0 males, it usually occurs in @entity0 and @entity0 . Immunohistochemistry provides solid criteria for diagnostics. Especially present pathognomonic Schiller-Duval bodies are helpful for identification. In this report, a 32-day-old Holstein Friesian @entity4 presented with a highly enlarged right testis. Sonographic examination was performed and blood samples were taken to measure @entity3 and @entity2 levels. Furthermore, the testis was surgically removed and macroscopically, histologically, and immunohistochemically examined which lead to the diagnosis of @entity5 . The second testis was descended until the age of nine months and histology revealed impaired spermatogenesis. This report provides the first sonographic images of @entity4 @entity5 as well as the first information about hormone levels in @entity4 with this @entity1 . It also shows the importance to combine anamnesis, histomorphological, and immunohistochemical findings in order to diagnose yolk sac @entity1 when pathognomonic structures are not present.

title: @entity5 and impaired spermatogenesis in a Holstein Friesian XXXX .

answer: @entity4


abstract: UNASSIGNED: The overarching goals of treatments for orthopedic conditions are generally to improve or restore function and alleviate @entity1 . Results of clinical trials are generally used to determine whether a treatment is efficacious; however, a statistically significant improvement may not actually be @entity2 , i.e., meaningful to the @entity0 . To determine whether an intervention has produced @entity2 benefits requires a two-step process: first, determining the magnitude of change considered @entity2 for a particular measure in the relevant population and, second, applying this yardstick to a @entity0 's data to determine whether s/he has benefited from treatment. Several metrics have been devised to quantify @entity2 differences, including the @entity2 ( @entity2 ) and @entity2 ( @entity2 ). Herein, we review the methods to generate the @entity2 and other metrics and their use and interpretation in clinical trials and practice. We particularly highlight the many pitfalls associated with the generation and utilization of these metrics that can impair their correct use. These pitfalls include the fact that different @entity1 measures yield different MCIDs, that efficacy in clinical trials is impacted by various factors (population characteristics, trial design), that the @entity2 value is impacted by the method used to calculate it (anchor, distribution), by the type of anchor chosen and by the definition (threshold) of improvement. The @entity2 is also dependent on the population characteristics such as disease type and severity, sex, age, etc. For appropriate use, the @entity2 should be applied to changes in individual subjects, not to group changes. The @entity2 and @entity2 are useful tools to define general guidelines to determine whether a treatment produces clinically meaningful effects. However, the many pitfalls associated with these metrics require a detailed understanding of the methods to calculate them and their context of use. Orthopedic surgeons that will use these metrics need to carefully understand them and be aware of their pitfalls.

title: Determining the clinical importance of treatment benefits for interventions for XXXX .

answer: @entity1


abstract: BACKGROUND: Severe @entity3 has limited therapeutic options. OBJECTIVES: To evaluate photodynamic therapy (PDT) using topical @entity5 ( @entity4 , 80 mg/g) as the photosensitiser in severe facial acne METHODS: Double-blind, randomised, vehicle-controlled multicentre trial in 153 @entity0 (12-35 years) with severe facial acne (Investigator Global Assessment [IGA] score 4; 25-75 inflammatory lesions with  <=3 nodules; 20-100 non-inflammatory lesions). Treatment (4 treatments 2 weeks apart) involved incubation with @entity4 (n=100) or vehicle cream (n=53) 1.5 hours under @entity2 , then illumination (635 nm red light, total dose 37 J/cm(2) ). IGA assessment and standardised lesion counts were performed before each treatment and 12 weeks after first treatment. Treatment success was defined as improvement from baseline in IGA by >= 2 grades at 12 weeks. Safety assessments were @entity1 (10 cm visual analogue scale [VAS], immediately after illumination), erythema (four-point rating scale) and adverse events. RESULTS: At 12 weeks, PDT using 80 mg/g @entity4 reduced inflammatory lesions versus vehicle PDT (mean change -15.6 vs. -7.8, p=0.006; mean percent change -37.3% vs. -16.2%, p=0.003). Although non-inflammatory lesions did not decrease significantly (mean change -11.8 vs. -10.7, p=0.85; mean percent change -28.6% vs. -24.9%, p=0.72). Treatment success rates were greater with 80 mg/g @entity4 PDT (44% vs. 26%, p=0.013). @entity1 was low and manageable by briefly pausing illumination. There was similar @entity1 or erythema with successive treatments. CONCLUSIONS: PDT using topical 80 mg/g @entity4 and red light may offer promise for severe @entity3 . [ClinicalTrials. gov Identifier NCT01347879; registered May 3, 2011]. This article is protected by copyright. All rights reserved.

title: Photodynamic therapy with 80 mg/g XXXX for severe @entity3 : a randomised vehicle-controlled study.

answer: @entity5


abstract: BACKGROUND: Severe @entity3 has limited therapeutic options. OBJECTIVES: To evaluate photodynamic therapy (PDT) using topical @entity5 ( @entity4 , 80 mg/g) as the photosensitiser in severe facial acne METHODS: Double-blind, randomised, vehicle-controlled multicentre trial in 153 @entity0 (12-35 years) with severe facial acne (Investigator Global Assessment [IGA] score 4; 25-75 inflammatory lesions with  <=3 nodules; 20-100 non-inflammatory lesions). Treatment (4 treatments 2 weeks apart) involved incubation with @entity4 (n=100) or vehicle cream (n=53) 1.5 hours under @entity2 , then illumination (635 nm red light, total dose 37 J/cm(2) ). IGA assessment and standardised lesion counts were performed before each treatment and 12 weeks after first treatment. Treatment success was defined as improvement from baseline in IGA by >= 2 grades at 12 weeks. Safety assessments were @entity1 (10 cm visual analogue scale [VAS], immediately after illumination), erythema (four-point rating scale) and adverse events. RESULTS: At 12 weeks, PDT using 80 mg/g @entity4 reduced inflammatory lesions versus vehicle PDT (mean change -15.6 vs. -7.8, p=0.006; mean percent change -37.3% vs. -16.2%, p=0.003). Although non-inflammatory lesions did not decrease significantly (mean change -11.8 vs. -10.7, p=0.85; mean percent change -28.6% vs. -24.9%, p=0.72). Treatment success rates were greater with 80 mg/g @entity4 PDT (44% vs. 26%, p=0.013). @entity1 was low and manageable by briefly pausing illumination. There was similar @entity1 or erythema with successive treatments. CONCLUSIONS: PDT using topical 80 mg/g @entity4 and red light may offer promise for severe @entity3 . [ClinicalTrials. gov Identifier NCT01347879; registered May 3, 2011]. This article is protected by copyright. All rights reserved.

title: Photodynamic therapy with 80 mg/g @entity5 for severe XXXX : a randomised vehicle-controlled study.

answer: @entity3


abstract: OBJECTIVE: We examined the prospective influence of the resilient, undercontrolled, and overcontrolled personality prototypes on @entity2 and @entity4 ( @entity4 ) symptoms among Iraq/Afghanistan war veterans. After accounting for the possible influence of combat exposure, we expected that the resilient prototype would predict lower @entity2 and @entity4 over time and would be associated with adaptive coping strategies, higher social support, lower @entity3 , and higher self-reported resilience relative to overcontrolled and undercontrolled prototypes, independent of @entity1 ( @entity1 ) status. METHOD: One hundred twenty-seven veterans (107 @entity0 , 20 @entity0 ; average age = 37) participated in the study. Personality was assessed at baseline, and @entity4 and @entity2 symptoms were assessed 8 months later. Path analysis was used to test the direct and indirect effects of personality on distress. RESULTS: No direct effects were observed from personality to distress. The resilient prototype did have significant indirect effects on @entity4 and @entity2 through its beneficial effects on social support, coping and @entity3 . @entity1 also had direct effects on @entity4 . CONCLUSIONS: A resilient personality prototype appears to influence veteran adjustment through its positive associations with greater social support and @entity3 , and lower use of avoidant coping. Low social support, avoidant coping, and @entity3 are related to overcontrolled and undercontrolled personality prototypes, and these behaviors seem to characterize veterans who experience problems with @entity2 and @entity4 over time. A positive @entity1 status is directly and prospectively associated with @entity4 symptomology independent of personality prototype. Implications for clinical interventions and future research are discussed.

title: Resilience, XXXX , @entity2 , and posttraumatic stress among Iraq/Afghanistan war veterans.

answer: @entity1


abstract: OBJECTIVE: We examined the prospective influence of the resilient, undercontrolled, and overcontrolled personality prototypes on @entity2 and @entity4 ( @entity4 ) symptoms among Iraq/Afghanistan war veterans. After accounting for the possible influence of combat exposure, we expected that the resilient prototype would predict lower @entity2 and @entity4 over time and would be associated with adaptive coping strategies, higher social support, lower @entity3 , and higher self-reported resilience relative to overcontrolled and undercontrolled prototypes, independent of @entity1 ( @entity1 ) status. METHOD: One hundred twenty-seven veterans (107 @entity0 , 20 @entity0 ; average age = 37) participated in the study. Personality was assessed at baseline, and @entity4 and @entity2 symptoms were assessed 8 months later. Path analysis was used to test the direct and indirect effects of personality on distress. RESULTS: No direct effects were observed from personality to distress. The resilient prototype did have significant indirect effects on @entity4 and @entity2 through its beneficial effects on social support, coping and @entity3 . @entity1 also had direct effects on @entity4 . CONCLUSIONS: A resilient personality prototype appears to influence veteran adjustment through its positive associations with greater social support and @entity3 , and lower use of avoidant coping. Low social support, avoidant coping, and @entity3 are related to overcontrolled and undercontrolled personality prototypes, and these behaviors seem to characterize veterans who experience problems with @entity2 and @entity4 over time. A positive @entity1 status is directly and prospectively associated with @entity4 symptomology independent of personality prototype. Implications for clinical interventions and future research are discussed.

title: Resilience, @entity1 , XXXX , and posttraumatic stress among Iraq/Afghanistan war veterans.

answer: @entity2


abstract: UNASSIGNED: Each @entity0 has its unique spatial shape, but the clinical importance and the underlying mechanism for the three-dimensional @entity3 shapes are mostly unknown. We collected the data on the three-dimensional @entity3 size and @entity3 volume data of invasive @entity0 from 2,250 @entity1 who underwent surgery between Jan 2000 and Jul 2007. The degree of @entity3 eccentricity was estimated by using the difference between the spheroid @entity3 volume and ellipsoid @entity3 volume (spheroid-ellipsoid discrepancy, @entity6 ). In 41 @entity1 , transcriptome and exome sequencing data obtained. Estimation of more accurate @entity3 burden by calculating ellipsoid @entity3 volumes did not improve the outcome prediction when compared to the traditional longest diameter measurement. However, the @entity3 eccentricity, which was measured by @entity6 , showed significant variation between the molecular subtypes of @entity0 . Additionally, the degree of @entity3 eccentricity was associated with well-known prognostic factors of @entity0 such as @entity3 size and lymph node @entity2 . Transcriptome data from 41 @entity1 showed significant association between @entity4 and @entity3 shapes. Network analysis and analysis of TCGA gene expression data suggest that @entity4 is regulated by @entity5 and @entity7 . The present study validates the usefulness of the current @entity3 size method in determining @entity3 stages. Furthermore, we show that the @entity3 with high eccentricity are more likely to have aggressive @entity3 characteristics. Genes involved in the extracellular matrix remodeling can be candidate regulators of the @entity3 shapes in @entity0 .

title: The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in XXXX .

answer: @entity0


abstract: Most adults with @entity3 ( @entity3 ) receive care for their acute @entity1 episodes in an @entity2 ( @entity2 ) setting. The purpose of this article is to describe the impact of opening a dedicated treatment center for adults with @entity3 [ @entity3 ( @entity3 )] on @entity0 outcomes and on hospital discharges for @entity3 . Descriptive data including demographics, time to first dose of narcotic, and @entity1 scores were collected on @entity0 presenting to the @entity3 and @entity2 . Maryland hospital discharge data were obtained from the Maryland Health Services Cost Review Commission. Analyses were conducted using T tests,   (2) tests, and simple generalized estimating equation regression models accounting for the clustered nature of observations, as appropriate. There were 3,874 visits to the @entity3 by 361 unique @entity0 ; 85% of those visits resulted in the @entity0 being sent home. During the same time period, there were 3,408 visits to the @entity2 by 558 unique @entity0 with @entity3 . The overall admission rate from the @entity2 for these @entity0 was 35.9% but decreased significantly over the time period with a rate of 20% in December 2011. There was a significant decrease in readmissions over time for the entire Baltimore Metro area with the likelihood of readmission decreasing by 7% over time. The @entity3 model provides adults with @entity3 access to high quality care that decreases the need for hospital admission. Further research needs to be done to evaluate the cost effectiveness of this model.

title: Impact of a dedicated infusion clinic for acute management of adults with sickle cell XXXX crisis.

answer: @entity1


abstract: UNASSIGNED: Background   The outcomes of @entity4 ( @entity4 ) between biatrial maze (BAM) and left atrial maze (LAM) are still controversial. The purpose of this study was to compare the clinical and rhythm outcomes between BAM and LAM in @entity0 with @entity4 . Methods   Electronic databases and article references were systematically searched (1990-2014) to access relevant studies. Odds ratio (OR) and @entity2 ( @entity2 ) with 95% confidence interval (CI) were reported. Results   Fourteen studies with 2,075 @entity0 were finally involved in the present meta-analysis. The rate of restored sinus rhythm (SR) was similar in BAM and LAM groups (OR: 1.25, 95% CI: 0.91-1.72, p   =   0.163). BAM reduced the prevalence of @entity5 during follow-up (OR: 0.12, 95% CI: 0.01-0.96, p   =   0.046). Compared with BAM, LAM shorten aortic cross-clamping time ( @entity2   =   9.05 minutes, 95% CI: 1.28-16.82, p   =   0.023) and cardiopulmonary bypass time ( @entity2   =   20.21 minutes, 95% CI: 7.40-33.03, p   =   0.002). No significant difference was found between groups in the risk of @entity1 (OR: 1.22, 95% CI: 0.70-2.14, p   =   0.233), cerebrovascular events (OR: 1.44, 95% CI: 0.51-4.06, p   =   0.493), and reoperation for @entity3 (OR: 1.34, 95% CI: 0.70-2.55, p   =   0.374). However, the risk for implantation of permanent pacemaker was significantly higher in BAM group (OR: 2.60, 95% CI: 1.09-6.20, p   =   0.031). Conclusion   No significant difference was found between BAM and LAM in the rate of restored SR, the risk of @entity1 , cerebrovascular events, and reoperation for @entity3 . BAM is superior to LAM in reducing the prevalence of @entity5 during follow-up, but LAM shortens the aortic cross-clamping time and cardiopulmonary bypass time, and decreases the risk of permanent pacemaker implantation.

title: Comparison of Left Atrial and Biatrial Maze Procedure in the Treatment of XXXX : A Meta-Analysis of Clinical Studies.

answer: @entity4