abstract: OBJECTIVE: To describe the epidemiologic and clinical characteristics of critically ill pregnant and postpartum @entity0 with @entity1 reported in the 2013-2014 season. METHODS: The California Department of Public Health conducts surveillance for @entity0 with laboratory-confirmed @entity3 who die or require hospitalization in intensive care units. For this case series, we reviewed data on pregnant and postpartum (6 weeks or less from delivery) @entity0 reported in the 2013-2014 @entity3 season. RESULTS: From September 29, 2013, through May 17, 2014, 17 pregnant @entity0 with severe @entity3 were reported. The median age was 29 years (range 17-44 years). Sixteen (94%) were in the second or third trimester. Fifteen (88%) @entity0 were hospitalized, nine (53%) required mechanical ventilation, five (29%) required emergent cesarean delivery, and four (24%) died. Of 14 @entity0 with available information, only two (14%) received @entity3 vaccination during pregnancy. Seven @entity0 who tested positive by polymerase chain reaction also had rapid @entity3 diagnostic testing performed; only one (14%) had a positive rapid @entity3 diagnostic test results. Fifteen patients received antiviral treatment; four (27%) began treatment within 48 hours of symptom onset. One additional @entity0 was 36 days postpartum and required intensive care unit admission and mechanical ventilation for @entity3 -associated acute @entity2 . CONCLUSION: Influenza remains a significant cause of morbidity and mortality in pregnant and postpartum @entity0 ; in our series, a majority were not vaccinated. During the @entity3 season, pregnant @entity0 with suspected @entity3 should receive prompt empiric antiviral therapy, regardless of rapid @entity3 diagnostic test results or vaccination status. LEVEL OF EVIDENCE: : III.

title: Pregnancy and severe XXXX in the 2013-2014 @entity3 season.

answer: @entity1


abstract: UNASSIGNED: Activity-induced @entity2 -dependent MRI (AIM-MRI) is a powerful tool to track system-wide neural activity using high resolution, quantitative T1-weighted MRI in animal models and has significant advantages for investigating neural activity over other modalities including BOLD fMRI. With AIM-MRI, @entity3 ions enter neurons via voltage-gated @entity1 channels preferentially active during the time of experimental exposure. A broad range of AIM-MRI studies using different species studying different phenomena have been performed, but few of these studies provide a systematic evaluation of the factors influencing the detection of @entity3 such as dosage and the temporal characteristics of @entity3 uptake. We identified an optimal dose of @entity3 (25mg/kg, s.c.) in order to characterize the time-course of @entity3 accumulation in active neural regions in the @entity0 . T1-weighted MRI and functional MRI were collected 0-3, 6-9, and 24-27h post- @entity3 injection while the vibrissae on the right side were vibrated. Significant BOLD activation in the left somatosensory (SS) cortex and left ventral posteromedial (VPM) thalamic nucleus was detected during whisker vibration. T1-weighted signal intensities were extracted from these regions, their corresponding contralateral regions and the visual cortex (to serve as controls). A significant elevation in T1-weighted signal intensity in the left SS cortex (relative to right) was evident 6-9 and 24-27h post- @entity3 injection while the left VPM thalamus showed a significant enhancement (relative to the right) only during the 24-27h session. Visual cortex showed no hemispheric difference at any timepoint. Our results suggest that studies employing AIM-MRI would benefit by conducting experimental manipulations 6-24h after subcutaneous @entity4 injections to optimize the concentration of contrast agent in the regions active during the exposure.

title: Activity-induced @entity2 -dependent MRI (AIM-MRI) and functional MRI in awake XXXX during somatosensory stimulation.

answer: @entity0


abstract: UNASSIGNED: Activity-induced @entity2 -dependent MRI (AIM-MRI) is a powerful tool to track system-wide neural activity using high resolution, quantitative T1-weighted MRI in animal models and has significant advantages for investigating neural activity over other modalities including BOLD fMRI. With AIM-MRI, @entity3 ions enter neurons via voltage-gated @entity1 channels preferentially active during the time of experimental exposure. A broad range of AIM-MRI studies using different species studying different phenomena have been performed, but few of these studies provide a systematic evaluation of the factors influencing the detection of @entity3 such as dosage and the temporal characteristics of @entity3 uptake. We identified an optimal dose of @entity3 (25mg/kg, s.c.) in order to characterize the time-course of @entity3 accumulation in active neural regions in the @entity0 . T1-weighted MRI and functional MRI were collected 0-3, 6-9, and 24-27h post- @entity3 injection while the vibrissae on the right side were vibrated. Significant BOLD activation in the left somatosensory (SS) cortex and left ventral posteromedial (VPM) thalamic nucleus was detected during whisker vibration. T1-weighted signal intensities were extracted from these regions, their corresponding contralateral regions and the visual cortex (to serve as controls). A significant elevation in T1-weighted signal intensity in the left SS cortex (relative to right) was evident 6-9 and 24-27h post- @entity3 injection while the left VPM thalamus showed a significant enhancement (relative to the right) only during the 24-27h session. Visual cortex showed no hemispheric difference at any timepoint. Our results suggest that studies employing AIM-MRI would benefit by conducting experimental manipulations 6-24h after subcutaneous @entity4 injections to optimize the concentration of contrast agent in the regions active during the exposure.

title: Activity-induced XXXX -dependent MRI (AIM-MRI) and functional MRI in awake @entity0 during somatosensory stimulation.

answer: @entity2


abstract: The aim of this study was to determine the causes and factors influencing maternal mortality. All maternal deaths occurring between January 2007 and November 2013 in the Elazig Province of @entity3 were retrospectively investigated. The maternal age, obstetric history, cause of @entity2 , encountered delay model of each case, as well as the overall number of annual live births in the Province were determined. The information of cases was obtained from Directorate of Public Health and hospital records.   Families or family doctors were also interviewed to obtain details about the circumstances surrounding each @entity2 . There were a total of 64,423 live births in the Province of Elazig between 2007- 2013. The number and ratio of maternal deaths due to direct and indirect causes were 12 and 18.6, respectively. The direct causes of maternal @entity2 were @entity1 diseases of pregnancy (n=5, 41.7%), @entity5 (n=3, 25%) and @entity6 (n=1, 8.3%). The indirect causes of @entity2 were @entity4 (n=2, 16.7%) and @entity0 (n=1, 8.3%). When classified according to the "Three Delays Model", 2 cases were in the first delay model and 3 cases in the third delay model; the second delay model led to no maternal deaths. @entity1 diseases of pregnancy are the leading cause of maternal mortality in our province. The preventable causes of maternal mortality and factors contributing to @entity2 must be identified to reduce the incidence.

title: Evaluation of maternal mortality cases in the province of Elazig, XXXX , 2007-2013: a retrospective study.

answer: @entity3


abstract: Part I of this paper has documented the evolution of dark neurons into acidophilic neurons in the superficial laminae as well as the reversion of dark neurons to normal neurons in the deep laminae of the cerebral cortex in @entity2 . The present study describes the temporal evolution of @entity2 in the hippocampus. The evolution of dark neurons to acidophilic neurons was confirmed in this brain region. Four additional problems were addressed: Firstly, delayed @entity3 was looked for, and was found to occur in areas of @entity4 undergoing mild damage. However, it was not preceded by a morphological free interval, had ultrastructural characteristics distinct from delayed @entity3 in @entity1 , and hence should be considered a distinct phenomenon. Secondly, the gradient in the density of @entity3 in the @entity0 hippocampal pyramidal cell band was exploited to test the hypothesis that a more severe insult causes a more rapid evolution of neuronal changes. This was found to be the case, with a temporal spectrum in the timing of @entity3 : Necrosis occurred already after 2 h medially in the subiculum, and was delayed by up to several weeks laterally in @entity4 . Thirdly, the almost universal sparing of @entity5 pyramidal neurons after 30 min hypoglycemic isoelectricity was exploited to address the question of whether reactive changes, which could with certainty be deemed reversible, occur in @entity5 . @entity6 was seen in these cells, and was found to be recoverable. No reactive changes of the type previously described following ischemic insults were observed. Fourthly, the astrocytic and vascular response of the tissue was studied. A sequence of astrocytic changes representing structural and probably metabolic activation of astrocytes was seen, consisting of morphological indices of increased turnover of cellular components. Capillaries demonstrated endothelial pits, vesicles, and prominent microvilli hours to days after recovery. The results demonstrate that, in the hippocampal gyrus as in other brain regions, @entity2 is distinct from @entity2 and likely has a different pathogenesis.

title: The temporal evolution of XXXX . II. Light- and electron-microscopic findings in the hippocampal gyrus and subiculum of the @entity0 .

answer: @entity2


abstract: Part I of this paper has documented the evolution of dark neurons into acidophilic neurons in the superficial laminae as well as the reversion of dark neurons to normal neurons in the deep laminae of the cerebral cortex in @entity2 . The present study describes the temporal evolution of @entity2 in the hippocampus. The evolution of dark neurons to acidophilic neurons was confirmed in this brain region. Four additional problems were addressed: Firstly, delayed @entity3 was looked for, and was found to occur in areas of @entity4 undergoing mild damage. However, it was not preceded by a morphological free interval, had ultrastructural characteristics distinct from delayed @entity3 in @entity1 , and hence should be considered a distinct phenomenon. Secondly, the gradient in the density of @entity3 in the @entity0 hippocampal pyramidal cell band was exploited to test the hypothesis that a more severe insult causes a more rapid evolution of neuronal changes. This was found to be the case, with a temporal spectrum in the timing of @entity3 : Necrosis occurred already after 2 h medially in the subiculum, and was delayed by up to several weeks laterally in @entity4 . Thirdly, the almost universal sparing of @entity5 pyramidal neurons after 30 min hypoglycemic isoelectricity was exploited to address the question of whether reactive changes, which could with certainty be deemed reversible, occur in @entity5 . @entity6 was seen in these cells, and was found to be recoverable. No reactive changes of the type previously described following ischemic insults were observed. Fourthly, the astrocytic and vascular response of the tissue was studied. A sequence of astrocytic changes representing structural and probably metabolic activation of astrocytes was seen, consisting of morphological indices of increased turnover of cellular components. Capillaries demonstrated endothelial pits, vesicles, and prominent microvilli hours to days after recovery. The results demonstrate that, in the hippocampal gyrus as in other brain regions, @entity2 is distinct from @entity2 and likely has a different pathogenesis.

title: The temporal evolution of @entity2 . II. Light- and electron-microscopic findings in the hippocampal gyrus and subiculum of the XXXX .

answer: @entity0


abstract: @entity7 occurs in     25-40% of @entity0 with @entity3 2 @entity1 . Given the high risk of @entity4 and @entity5 , early identification of @entity0 with a renal risk is important. Novel biomarkers may aid in improving renal risk stratification. In this review, we first focus on the classical panel of @entity6 and estimated glomerular filtration rate as the primary clinical predictors of @entity2 and then move our attention to novel biomarkers, primarily concentrating on assay-based multiple/panel biomarkers, proteomics biomarkers and metabolomics biomarkers. We focus on multiple biomarker panels since the molecular processes of @entity2 progression in @entity3 2 @entity1 are heterogeneous, rendering it unlikely that a single biomarker significantly adds to clinical risk prediction. A limited number of prospective studies of multiple biomarkers address the predictive performance of novel biomarker panels in addition to the classical panel in @entity3 2 @entity1 . However, the prospective studies conducted so far have small sample sizes, are insufficiently powered and lack external validation. Adequately sized validation studies of multiple biomarker panels are thus required. There is also a paucity of studies that assess the effect of treatments on novel biomarker panels and determine whether initial treatment-induced changes in novel biomarkers predict changes in long-term renal outcomes. Such studies can not only improve our healthcare but also our understanding of the mechanisms of actions of existing and novel drugs and may yield biomarkers that can be used to monitor drug response. We conclude that this will be an area to focus research on in the future.

title: Prognostic clinical and molecular biomarkers of XXXX .

answer: @entity7


abstract: BACKGROUND: Few studies have examined @entity2 in track and field in both elite and subelite athletes. PURPOSE: To observe the absolute number and relative rates of @entity3 across a wide range of competition levels and ages during 3 years of the Penn Relays Carnival to assist with future medical coverage planning and injury prevention strategies. STUDY DESIGN: Descriptive epidemiology study. METHODS: Over a 3-year period, all injuries treated by the medical staff were recorded on a standardized injury report form. Absolute number of @entity1 rates (number of injuries per 1000 competing athletes) were determined and odds ratios (ORs) of injury rates were calculated between sexes, competition levels, and events. @entity1 were also broken down into major or minor medical or orthopaedic injuries. RESULTS: Throughout the study period, 48,473 competing athletes participated in the Penn Relays Carnival, and 436 injuries were sustained. For medical coverage purposes, the relative rate of injury subtypes was greatest for @entity1 (5.71 injuries per 1000 @entity0 ), followed by minor medical injuries (3.42 injuries per 1000 @entity0 ), major medical injuries (0.69 injuries per 1000 @entity0 ), and major orthopaedic injuries (0.18 injuries per 1000 @entity0 ). College/elite athletes displayed the @entity1 rate (7.99 injuries per 1000 @entity0 ), which was significantly less than that of high school (9.87 injuries per 1000 @entity0 ) and masters athletes (16.33 injuries per 1000 @entity0 ). Male athletes displayed a greater likelihood of having a minor @entity1 compared with female athletes (OR, 1.36 [95% CI, 1.06-1.75];   (2) = 5.73; P = .017) but were less likely to sustain a major @entity1 (OR, 0.33 [95% CI, 0.15-0.75];   (2) = 7.75; P = .005). Of the 3 most heavily participated in events, the 4 * 400-m relay displayed the greatest relative injury rate (13.6 injuries per 1000 @entity0 ) compared with the 4 * 100-m and 4 * 200-m relays. CONCLUSION: Medical coverage teams for future large-scale track and field events need to plan for at least 2 major orthopaedic and 7 major medical injuries per 10,000 @entity0 . Male track and field athletes, particularly masters male athletes, are at greater risk of injury compared with other sexes and competition levels.

title: Acute XXXX in Track and Field Athletes: A 3-Year Observational Study at the Penn Relays Carnival With Epidemiology and Medical Coverage Implications.

answer: @entity1


abstract: The objective of this meta-analysis was to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of @entity2 in @entity0 with @entity1 in order to arrive at qualitative and quantitative conclusions about the efficacy of rTMS. We included randomized controlled trials examining the effects of rTMS compared with sham-rTMS or selective @entity3 re-uptake inhibitors (SSRIs). The quality of included studies was strictly evaluated. Data analyses were performed using the RevMan5.1 software. Eight studies including 312 @entity0 met all inclusion criteria. The results showed that rTMS could evidently improve the HRSD score compared with sham-rTMS (p < 0.00001). However, we found similar antidepressant efficacy between rTMS and SSRIs groups in terms of HRSD and BDI score (p = 0.65; p = 0.75, respectively). Furthermore, @entity0 who received rTMS could evidently show improvement on the unified @entity1 rating scale (UPDRS), ADL score, and UPDRS motor score compared with sham-rTMS or SSRIs (p < 0.05, p = 0.05, respectively). The subgroup analysis by frequency of rTMS evidenced that the efficacy of low-frequency rTMS was superior to sham-rTMS (p < 0.0001) in terms of the outcome measure according to HAMD scale. Meanwhile, the high-frequency rTMS has the same antidepressant efficacy as SSRIs (p = 0.94). The current meta-analysis provided evidence that rTMS was superior to sham-rTMS and had similar antidepressant efficacy as SSRIs, and may have the additional advantage of some improvement in motor function.

title: Repetitive transcranial magnetic stimulation (rTMS) for the treatment of XXXX in @entity1 : a meta-analysis of randomized controlled clinical trials.

answer: @entity2


abstract: The objective of this meta-analysis was to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of @entity2 in @entity0 with @entity1 in order to arrive at qualitative and quantitative conclusions about the efficacy of rTMS. We included randomized controlled trials examining the effects of rTMS compared with sham-rTMS or selective @entity3 re-uptake inhibitors (SSRIs). The quality of included studies was strictly evaluated. Data analyses were performed using the RevMan5.1 software. Eight studies including 312 @entity0 met all inclusion criteria. The results showed that rTMS could evidently improve the HRSD score compared with sham-rTMS (p < 0.00001). However, we found similar antidepressant efficacy between rTMS and SSRIs groups in terms of HRSD and BDI score (p = 0.65; p = 0.75, respectively). Furthermore, @entity0 who received rTMS could evidently show improvement on the unified @entity1 rating scale (UPDRS), ADL score, and UPDRS motor score compared with sham-rTMS or SSRIs (p < 0.05, p = 0.05, respectively). The subgroup analysis by frequency of rTMS evidenced that the efficacy of low-frequency rTMS was superior to sham-rTMS (p < 0.0001) in terms of the outcome measure according to HAMD scale. Meanwhile, the high-frequency rTMS has the same antidepressant efficacy as SSRIs (p = 0.94). The current meta-analysis provided evidence that rTMS was superior to sham-rTMS and had similar antidepressant efficacy as SSRIs, and may have the additional advantage of some improvement in motor function.

title: Repetitive transcranial magnetic stimulation (rTMS) for the treatment of @entity2 in XXXX : a meta-analysis of randomized controlled clinical trials.

answer: @entity1


abstract: OBJECTIVE: Geographic patterns in total mortality and in mortality by cause of @entity2 are widely known to exist in many countries. However, the geographic pattern of inequalities in mortality within these countries is unknown. This study shows mathematically and graphically the geographic pattern of mortality inequalities by education in Spain. METHODS: Data are from a nation-wide prospective study covering all @entity0 living in Spain's 50 provinces in 2001. Individuals were classified in a cohort of subjects with low education and in another cohort of subjects with high education. Age- and sex-adjusted mortality rate from all causes and from leading causes of @entity2 in each cohort and mortality rate ratios in the low versus high education cohort were estimated by geographic coordinates and province. RESULTS: Latitude but not longitude was related to mortality. In subjects with low education, latitude had a U-shaped relation to mortality. In those with high education, mortality from all causes, and from cardiovascular, respiratory and digestive diseases decreased with increasing latitude, whereas @entity1 mortality increased. The mortality-rate ratio for all-cause @entity2 was 1.27 in the southern latitudes, 1.14 in the intermediate latitudes, and 1.20 in the northern latitudes. The mortality rate ratios for the leading causes of @entity2 were also higher in the lower and upper latitudes than in the intermediate latitudes. The geographic pattern of the mortality rate ratios is similar to that of the mortality rate in the low-education cohort: the highest magnitude is observed in the southern provinces, intermediate magnitudes in the provinces of the north and those of the Mediterranean east coast, and the lowest magnitude in the central provinces and those in the south of the Western Pyrenees. CONCLUSION: Mortality inequalities by education in Spain are higher in the south and north of the country and lower in the large region making up the central plateau. This geographic pattern is similar to that observed in mortality in the low-education cohort.

title: The Association of Geographic Coordinates with Mortality in XXXX with Lower and Higher Education and with Mortality Inequalities in Spain.

answer: @entity0


abstract: UNASSIGNED: Age is a known susceptibility factor for the @entity7 of several anticancer drugs, including @entity10 ( @entity8 ). The impact of anticancer drugs in young @entity0 is underestimated, thus we aimed to evaluate the @entity7 of @entity8 in juvenile and adult animals. Juvenile (3 week-old) and adult (8-10 week-old) male CD-1 @entity1 were used. Each group was treated with a 9.0mg/kg cumulative dose of @entity8 or saline; they were maintained in a drug-free period for 3-weeks after the last administration to allow the development of late @entity2 (protocol 1), or sacrificed 24h after the last @entity8 administration to evaluate early @entity7 (protocol 2). In protocol 1, no adult @entity1 survived, while 2 of the juveniles reached the end of the protocol. High plasma @entity4 aminotransferase/ @entity5 aminotransferase ratio and a high cardiac reduced/oxidized @entity9 ratio were found in the surviving @entity8 -treated juvenile @entity1 . In protocol 2, a significant decrease in plasma @entity6 -kinase MB in juveniles was found 24h after the last @entity8 -administration. Cardiac histology showed that both @entity8 -treated populations had significant damage, although higher in adults. However, @entity8 -treated juveniles had a significant increase in fibrotic tissue. The @entity8 -treated adults had higher values of cardiac GSSG and protein carbonylation, but lower cardiac noradrenaline levels. For the first time, mature adult animals were shown to be more susceptible to @entity8 as evidenced by several biomarkers, while young animals appear to better adjust to the @entity8 -induced @entity3 . Even so, the higher level of fibrotic tissue and the histological damage showed that @entity8 also causes @entity3 in the juvenile population.

title: The age factor for XXXX 's @entity7 : Multiple doses render the adult @entity1 heart more susceptible to injury.

answer: @entity10


abstract: UNASSIGNED: Age is a known susceptibility factor for the @entity7 of several anticancer drugs, including @entity10 ( @entity8 ). The impact of anticancer drugs in young @entity0 is underestimated, thus we aimed to evaluate the @entity7 of @entity8 in juvenile and adult animals. Juvenile (3 week-old) and adult (8-10 week-old) male CD-1 @entity1 were used. Each group was treated with a 9.0mg/kg cumulative dose of @entity8 or saline; they were maintained in a drug-free period for 3-weeks after the last administration to allow the development of late @entity2 (protocol 1), or sacrificed 24h after the last @entity8 administration to evaluate early @entity7 (protocol 2). In protocol 1, no adult @entity1 survived, while 2 of the juveniles reached the end of the protocol. High plasma @entity4 aminotransferase/ @entity5 aminotransferase ratio and a high cardiac reduced/oxidized @entity9 ratio were found in the surviving @entity8 -treated juvenile @entity1 . In protocol 2, a significant decrease in plasma @entity6 -kinase MB in juveniles was found 24h after the last @entity8 -administration. Cardiac histology showed that both @entity8 -treated populations had significant damage, although higher in adults. However, @entity8 -treated juveniles had a significant increase in fibrotic tissue. The @entity8 -treated adults had higher values of cardiac GSSG and protein carbonylation, but lower cardiac noradrenaline levels. For the first time, mature adult animals were shown to be more susceptible to @entity8 as evidenced by several biomarkers, while young animals appear to better adjust to the @entity8 -induced @entity3 . Even so, the higher level of fibrotic tissue and the histological damage showed that @entity8 also causes @entity3 in the juvenile population.

title: The age factor for @entity10 's XXXX : Multiple doses render the adult @entity1 heart more susceptible to injury.

answer: @entity7


abstract: UNASSIGNED: Age is a known susceptibility factor for the @entity7 of several anticancer drugs, including @entity10 ( @entity8 ). The impact of anticancer drugs in young @entity0 is underestimated, thus we aimed to evaluate the @entity7 of @entity8 in juvenile and adult animals. Juvenile (3 week-old) and adult (8-10 week-old) male CD-1 @entity1 were used. Each group was treated with a 9.0mg/kg cumulative dose of @entity8 or saline; they were maintained in a drug-free period for 3-weeks after the last administration to allow the development of late @entity2 (protocol 1), or sacrificed 24h after the last @entity8 administration to evaluate early @entity7 (protocol 2). In protocol 1, no adult @entity1 survived, while 2 of the juveniles reached the end of the protocol. High plasma @entity4 aminotransferase/ @entity5 aminotransferase ratio and a high cardiac reduced/oxidized @entity9 ratio were found in the surviving @entity8 -treated juvenile @entity1 . In protocol 2, a significant decrease in plasma @entity6 -kinase MB in juveniles was found 24h after the last @entity8 -administration. Cardiac histology showed that both @entity8 -treated populations had significant damage, although higher in adults. However, @entity8 -treated juveniles had a significant increase in fibrotic tissue. The @entity8 -treated adults had higher values of cardiac GSSG and protein carbonylation, but lower cardiac noradrenaline levels. For the first time, mature adult animals were shown to be more susceptible to @entity8 as evidenced by several biomarkers, while young animals appear to better adjust to the @entity8 -induced @entity3 . Even so, the higher level of fibrotic tissue and the histological damage showed that @entity8 also causes @entity3 in the juvenile population.

title: The age factor for @entity10 's @entity7 : Multiple doses render the adult XXXX heart more susceptible to injury.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: For several decades an association between MGUS, IgM-MGUS in particular, and @entity3 has been suspected. Several histopathology studies have shown binding of IgM to myelin and a secondary widening of myelin lamellae in cutaneous nerves and in the sural nerve of @entity0 with IgM-MGUS, or Waldenstr  m's @entity4 (WM), and @entity3 . In this retrospective study we investigated the value of skin biopsy examination in the diagnosis of MGUS- and WM-associated @entity3 . METHODS: A total of 117 @entity0 , who were examined for an M-component in serum with associated nerve symptoms, had a skin biopsy taken and examined for immunoglobulin deposition in cutaneous nerves. Thirty-five @entity0 were diagnosed with MGUS or WM and @entity3 with no other cause of @entity1 . Nineteen @entity0 had MGUS but no @entity3 . RESULTS: Of the 35 @entity0 with MGUS or WM and @entity3 , four had immunoglobulin deposition in the skin biopsy, all of whom had an @entity2 . In the control group of 19 without @entity3 , three had immunoglobulin deposition in the skin biopsy, all of whom had IgM-MGUS. In both groups, there was a trend towards higher IgM blood levels in @entity0 with immunoglobulin deposition. Half of the @entity0 with @entity2 in the @entity1 group had anti-MAG reactivity, whereas only one in the control group had weak anti-MAG reactivity. CONCLUSION: Our study indicates that examination of skin biopsies for immunoglobulin deposition does not add significant diagnostic value in the evaluation of @entity1 suspected to be caused by MGUS or WM. IgM immunoglobulin deposition in skin biopsy might merely be an epiphenomenon secondary to high IgM blood levels.

title: Immunostaining of skin biopsy adds no diagnostic value in MGUS-associated XXXX .

answer: @entity3


abstract: OBJECTIVES: To compare the effectiveness of a daily home-based facial exercise therapy with a supervised rehabilitation technique for the treatment of postoperative @entity2 in @entity0 undergoing conventional superficial parotidectomy. DESIGN: Prospective, randomized trial, controlled. SETTING: Surgery and Rehabilitation Units, university hospital. SUBJECTS: Consecutive @entity0 (n=79, mean age 48 years) who underwent superficial parotidectomy with @entity3 were randomly divided into two groups. INTERVENTION: Control group (CG) were given a daily homework manual to perform ordinary postoperative facial mimic exercises autonomously in front of the mirror at home. Experimental group (EG) @entity0 with moderate-severe paresis received supervised rehabilitation therapy that consisted in weekly sessions with facial exercises and massages and performed daily facial exercises at home. EG @entity0 with slight paresis were instructed to undertake self-massage and mirror exercises. MAIN OUTCOME MEASURES: @entity1 of facial nerve and branches was quantified measuring the prevalence, magnitude and duration of paresis by the House-Brackmann Facial Nerve Grading System up to 12(th) months. RESULTS: Facial paresis incidence at 1(st) week was 77.2%, being the marginal-mandibular nerve the most affected (64.5%). No statistically significant differences were found at any time of the study when comparing the frequency, magnitude and duration of paresis between EG and CG and among @entity0 who had presented moderate-severe paresis. In the absence of @entity4 , complete recovery of facial mobility was observed within 12 months, regardless of treatment group. CONCLUSION: Rehabilitation therapy and mirror facial exercises performed autonomously at home were equally effective for postoperative functional recovery.

title: Effectiveness of XXXX after superficial parotidectomy: A randomized controlled trial.

answer: @entity3


abstract: OBJECTIVES/HYPOTHESIS: The incidence of @entity3 is rising. Few studies have examined @entity0 characteristics that influence survival when adjusting for treatment and @entity1 stage/extent. STUDY DESIGN: Retrospective analysis was performed using the Surveillance Epidemiology and End Results registry data among @entity0 diagnosed with well-differentiated @entity3 during 1988-2009. METHODS: Kaplan-Meir survival curves were used to estimate 5- and 10-year cause-specific and overall survival differences by sociodemographics, clinical characteristics, and treatment. Multivariate Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: A total of 83,985 @entity0 were identified with @entity3 . Blacks had higher hazard of @entity2 at 5 years (HR, 1.67; 95% CI, 1.42-1.96) and 10 years (HR, 1.57; 95% CI, 1.37-1.80) when compared to Caucasians, but there were no significant differences in cause-specific deaths. Hispanics had higher overall and cause-specific 5-year and 10-year hazard of @entity2 (5-year cause-specific: HR, 1.56; 95% CI, 1.23-1.99). Age was the most significant predictor of cause-specific and overall survival, with risk increasing in a nonlinear fashion. After age 45 years, the HR for 5- and 10-year cause-specific survival rose drastically, reaching an HR of 153 for individuals aged 85 years and older (HR, 153.45; 95% CI, 97.84-240.67). CONCLUSIONS: Age was the strongest factor associated with WDT @entity1 in our study. African Americans had worse overall survival, although only Hispanics had a significantly worse cause-specific survival. These factors should be taken into account in counseling @entity0 and treatment planning. LEVEL OF EVIDENCE: 2c. Laryngoscope, 2014.

title: Prognostic indicators in well-differentiated XXXX when controlling for stage and treatment.

answer: @entity3


abstract: OBJECTIVE: @entity4 ( @entity4 ) is a phosphaturic agent involved in calcium-phosphate homeostasis. Recent findings show that @entity5 and @entity1 regulate @entity4 release and/or biodegradation. @entity5 is frequently observed in the elderly, therefore the aim of this study was to find out if @entity5 is independent from low grade inflammatory factors affecting both forms of @entity4 that are detectable in circulation in a large population-based study of elderly subjects. DESIGN AND METHODS: The analysis included 3780 elderly (1798 females) PolSenior study @entity0 and assessed levels of phosphorus, calcium, iron, ferritin, @entity2 , @entity3 (hs-CRP), intact (iFGF23), and c-terminal FGF (cFGF23). The analysis was performed for all subjects and terciles of serum iron levels in relation to hs-CRP were calculated. RESULTS: The highest plasma cFGF23 and iFGF23 concentrations were found in subjects with the lowest serum iron levels (p<0.001). The effect of low grade @entity1 was markedly weaker and affected only iFGF23 levels. The adjusted serum levels of hs-CRP, iPTH, phosphorus, and 25-(OH)-D3 analysis revealed that plasma iFGF23 and cFGF23 levels were almost unchanged up to a serum iron level of 59.3ng/mL and 57.3ng/mL respectively and then were nearly linearly increasing by 0.285pg/mL and 3.742RU/mL for each unit of serum iron increase. CONCLUSIONS: Low iron levels are associated with increased levels of both cFGF23 and iFGF23, independent of low grade @entity1 . A similar analysis of cFGF23 and iFGF23 does not suggest enhanced biodegradation of iFGF23 induced by @entity5 .

title: Plasma XXXX concentration and iron status. Does the relationship exist in the elderly population?

answer: @entity4


abstract: An isolated, blood-perfused phrenic nerve-diaphragm preparation of the @entity1 was developed for pharmacological investigation. A hemi-diaphragm with the ipsi-lateral phrenic nerve intact was excised from a @entity1 anesthetized with @entity6 and was perfused with arterial blood from a donor @entity1 through the phrenic artery. This preparation maintained its tone and response in good condition for 10 hr without any deterioration of twitch tension. Effects of @entity4 , @entity3 , @entity7 , and @entity8 on twitch tension and blood flow of this preparation were studied. Drugs were injected into the phrenic artery. All four compounds produced a dose-dependent @entity2 of twitch tension elicited by indirect stimulation applied to the phrenic nerve without any @entity2 in the tension elicited by direct stimulation applied to the muscle. The ratios of the potency to produce a 50% @entity2 in twitch tension elicited by indirect stimulation among @entity4 , @entity7 , @entity3 , and @entity8 were roughly 1:1/3:1/3:1/30 on a weight (mg) basis. @entity3 produced a dose-dependent increase in blood flow. Other compounds did not cause significant changes in blood flow. The increase in blood flow produced by @entity3 was markedly inhibited by @entity5 , which suggested @entity0 release by @entity3 .

title: Isolated, blood-perfused phrenic nerve-diaphragm preparation of the XXXX : description of a new method and effects of neuromuscular blocking agents on twitch tension and blood flow.

answer: @entity1


abstract: UNASSIGNED: The adjuvant activity of @entity1 interleukin-12 (chIL-12) protein has been described as similar to that of @entity0 IL-12. Recombinant chIL-12 can be produced using several methods, but chIL-12 production in eukaryotic cells is lower than that in prokaryotic cells. Stimulating compounds, such as @entity2 ( @entity2 ), can be added to animal cell cultures to overcome this drawback. In this study, we constructed a cell line, DF1/chIL-12 which stably expressed a fusion protein, chIL-12 and enhanced green fluorescent protein (eGFP) connected by a ( @entity3 )3 linker sequence. Fusion protein production was increased when cells were cultured in the presence of @entity2 . When 1 * 10(6) DF1/chIL-12 cells were inoculated in a T-175 flask containing 30 mL of media, incubated for 15 h, and further cultivated in the presence of 4% @entity2 for 48 h, the production of total fusion protein was mostly enhanced compared with the production of total fusion protein by using cell lysates induced with @entity2 at other concentrations. The concentrations of the unpurified and purified total fusion proteins in cell lysates were 2,781    2.72 ng mL(-1) and 2,207    3.28 ng mL(-1) , respectively. The recovery rate was 79%. The fusion protein stimulated @entity1 splenocytes to produce IFN-y, which was measured using an enzyme-linked immunosorbent assay, in the culture supernatant, indicating that treating DF1/chIL-12 cells with @entity2 or producing chIL-12 in a fusion protein form does not have adverse effects on the bioactivity of chIL-12.    2015 American Institute of Chemical Engineers Biotechnol. Prog., 31:641-649, 2015.

title: Production and characterization of active recombinant interleukin-12/eGFP fusion protein in stably-transfected DF1 XXXX cells.

answer: @entity1


abstract: UNASSIGNED: To limit the spread of Middle East @entity1 coronavirus ( @entity2 -CoV) in Saudi Arabia, the Ministry of Health tried to raise public awareness using different public campaigns. We aimed to measure public awareness of @entity2 in Saudi Arabia. A cross-sectional study was conducted between May and June 2014 using a newly designed Arabic questionnaire that was distributed and completed online. We analyzed the response of 1149 respondents across Saudi Arabia. We found that 97% of the @entity0 were aware of @entity2 . In addition, 72% realized that coughing and sneezing could spread the infection. Furthermore, 83% thought that some @entity0 with @entity2 could be cured. Moreover, 62% knew that no vaccine can prevent the disease. However, only 36% realized that taking antibiotics will not stop the infection, and only 41% recognized that no medication has yet been manufactured to treat it. Regarding protection measures, 74% used hand sanitizers, 43% avoided crowded places, and 11% wore masks in public places. Moreover, only 47% knew that bats and @entity3 are the primary source of the virus. As anticipated, this level of awareness varied between the different categories of the studied population. Female, married, older, and more educated @entity0 were significantly more knowledgeable about the disease. Public awareness of @entity2 is generally sufficient. However, some false beliefs about treatment were fairly common. In addition, almost half of the population remains unaware that bats and @entity3 are the most likely sources of the virus.

title: Is the Saudi public aware of Middle East XXXX ?

answer: @entity1


abstract: UNASSIGNED: Progressive loss of cortical gray matter (GM) and increase of @entity3 have been reported in early-onset @entity2 (EOP). EOP typically begins during adolescence, a time when developmental brain trajectories differ by gender. This study aimed to determine gender differences in progression of brain changes in this population. A sample of 61 (21 females) adolescents with a first @entity2 and a matched sample of 70 (23 females) controls underwent both baseline and 2-year follow-up anatomical brain imaging assessments. Regional GM and @entity3 volumes were obtained using automated methods based on the Talairach's proportional grid system. At baseline, only male @entity0 showed a clear pattern of alterations in the frontal lobe relative to controls (smaller GM and larger @entity3 volumes). However, parallel longitudinal changes for male and female @entity0 relative to controls were observed, resulting in a common pattern of brain changes across both genders: rate of @entity1 was larger in male (-3.8  %) and female @entity0 (-4.2  %) than in controls (-0.7  % males; -0.4  % females). The reverse was found for the @entity3 volume in the @entity1 . While the GM and @entity3 volumes of females with EOP appear to be within the normal range at initial illness onset, our results point to a similar trajectory of increased/accelerated brain changes in both male and female @entity0 with EOP. The pattern of progression of brain changes in @entity2 appears to be independent of gender or structural alterations on appearance of @entity2 .

title: Gender effects on brain changes in early-onset XXXX .

answer: @entity2


abstract: UNASSIGNED: Biodosimetry, the measurement of radiation damage in a biologic sample, is a reliable tool for increasing the accuracy of dose estimation. Although established chromosome analyses are suitable for estimating the absorbed dose after high-dose irradiation, biodosimetric methodology to measure damage following low-dose exposure is underdeveloped. RNA analysis of circulating blood containing radiation-sensitive cells is a candidate biodosimetry method. Here we quantified RNA from a small amount of blood isolated from @entity1 following low-dose body irradiation (<0.5 Gy) aimed at developing biodosimetric tools for situations that are difficult to study in @entity0 . By focusing on radiation-sensitive undifferentiated cells in the blood based on @entity4 RNA expression, we quantified the relative levels of RNA for DNA damage-induced (DDI) genes, such as @entity2 , @entity5 and @entity3 . The RNA ratios of DDI genes/ @entity4 in the blood increased in a dose-dependent manner 4 h after whole-body irradiation at doses ranging from 0.1 to 0.5 Gy (air-kerma) of X-rays, regardless of whether the @entity1 were in an active or resting state. The RNA ratios were significantly increased after 0.014 Gy (air-kerma) of single X-ray irradiation. The RNA ratios were directly proportional to the absorbed doses in water ranging from 0.1 to 0.5 Gy, based on gamma-irradiation from (137)Cs. Four hours after continuous irradiation with gamma-rays or by internal contamination with a beta-emitter, the increased RNA ratios resembled those following single irradiation. These findings indicate that the RNA status can be utilized as a biodosimetric tool to estimate low-dose radiation when focusing on undifferentiated cells in blood.

title: Quantification of damage due to low-dose radiation exposure in XXXX : construction and application of a biodosimetric model using mRNA indicators in circulating white blood cells.

answer: @entity1


abstract: Threat induces a state of sustained @entity0 that can disrupt cognitive processing, and, reciprocally, cognitive processing can modulate an @entity0 response to threat. These effects depend on the level of cognitive engagement, which itself varies as a function of task difficulty. In adults, we recently showed that induced @entity0 working memory accuracy at low and medium but not high load. Conversely, increasing the task load reduced the physiological correlates of @entity0 ( @entity0 -potentiated @entity1 ). The present work examines such threat-cognition interactions as a function of age. We expected threat to more strongly impact working memory in younger individuals by virtue of putatively restricted cognitive resources and weaker emotion regulation. This was tested by examining the influence of age on the interaction of @entity2 in 25 adolescents (10 to 17 years) and 25 adults (22 to 46 years). Working memory load was manipulated using a verbal n-back task. @entity0 was induced using the threat of an aversive loud scream and measured via eyeblink @entity1 . Findings revealed that, in both age groups, accuracy was lower during threat than safe conditions at low and medium but not high load, and reaction times were faster during threat than safe conditions at high load but did not differ at other loads. Additionally, @entity0 -potentiated @entity1 was greater during low and medium than high load. Thus, the interactions of @entity2 appear similar in adolescents and adults. Whether these similarities reflect common neural mechanisms would need to be assessed using functional neuroimaging.

title: Interaction of threat and XXXX in adolescents.

answer: @entity2


abstract: BACKGROUND: Efficacy of guideline @entity3 prevention regimens may differ between @entity0 with or without @entity1 . We therefore compared change in carotid artery wall dimensions in @entity1 and @entity1 @entity0 with a history of a major @entity3 event, using magnetic resonance imaging. METHODS: Thirty @entity1 @entity0 and 29 age- and sex-matched @entity1 @entity0 with a history of @entity2 or @entity5 and a @entity4 (15%-70%) were included. In all @entity0 , treatment was according to cardiovascular risk management guidelines. At baseline and follow-up, carotid artery vessel wall dimensions were measured using 1.5   T magnetic resonance imaging. RESULTS: After 2   years of follow-up, total wall volume of the carotid artery in @entity1 @entity0 decreased by 9.6% (p   =   0.016). In contrast, stabilization rather than regression of carotid artery wall dimensions was observed in @entity1 @entity0 over a 2-year period. Body mass index was identified as a predictor of total wall volume decrease. CONCLUSIONS: Guideline treatment arrests atherogenesis in @entity1 @entity0 and even decreases vessel wall dimensions in @entity1 @entity0 . Baseline body mass index predicts @entity3 prevention efficacy expressed as decrease in total wall volume. These data emphasize the importance of optimal cardiovascular-prevention, particularly in @entity1 @entity0 with a high body mass index.

title: Guideline treatment results in regression of atherosclerosis in XXXX .

answer: @entity1


abstract: UNASSIGNED: Earlier attempts at percutaneous closure of perimembranous @entity5 (Pm  VSDs) were abandoned because of incidence of @entity3 likely as a result of @entity6 and/or oversizing. This is retrospective review and data reporting of @entity0 who underwent percutaneous closure using the softer second-generation Amplatzer vascular occluders; namely the Amplatzer vascular plug, second generation, (AVP II) and the Amplatzer duct occluder, second generation (ADO II) in our institution. A total of 20 @entity0 were identified; AVP II was used in 9 @entity0 and ADO II in 11 @entity0 . Median weight was 13.45  kg (range 6.5 to 76); age 28.5  months (range 11 to 352). After procedure, 4 were noted to have @entity2 ; trivial in 3 and mild in 1  (unrelated  to the device). Mild @entity4 possibly device or procedure related was seen in 4. Residual flow through the device was common after procedure and disappeared in all but 3, graded as trivial in 1, small in 2. Average follow-up period was 7.54 months    7.5 (1  day to 25  months). There was no incidence of @entity3 , @entity8 , @entity7 , device embolization, or @entity1 . The @entity2 resolved in 1 @entity0 and was estimated to be trivial in the remaining 3 @entity0 . In conclusion, percutaneous closure of Pm VSDs using the softer new generation devices as the AVP II and the ADO II is feasible and safe. Longer follow-up and larger series are needed.

title: Percutaneous Closure of Perimembranous XXXX Using the Second-Generation Amplatzer Vascular Occluders.

answer: @entity5


abstract: PURPOSE: This phase I study aimed to establish the biologic effects and MTD of the agonistic IgG1 chimeric anti- @entity6 antibody ChiLob7/4 in @entity0 (pts) with a range of @entity6 -expressing solid @entity1 and diffuse large @entity4 , resistant to conventional therapy. Potential mechanisms of action for agonistic anti- @entity6 include direct cytotoxic effects on @entity1 cells and conditioning of antigen-presenting cells. EXPERIMENTAL DESIGN: ChiLob7/4 was given by IV infusion weekly for 4 doses at a range from 0.5 to 240 mg/dose. Validated ELISAs were used to quantify ChiLob7/4 in serum and test for anti-chimeric MAb (HACA) responses. Pharmacodynamic assessments included quantitation of T-cell, natural killer-cell, and B-cell numbers and activation in blood by flow cytometry and a panel of cytokines in plasma by Luminex technology. Planned dose escalation was in cohorts of 3 @entity0 until MTD or biologic effect, defined as reduction of peripheral blood @entity3 (+) B cells to 10% or less of baseline. RESULTS: Twenty-nine courses of treatment were given to 28 subjects. The MTD was 200 mg * 4, with dose-limiting @entity2 of liver transaminase elevations at 240 mg. At 200 mg (range between 2.1 mg/kg and 3.3 mg/kg based on @entity0 body weight), the trough level pretreatment was above 25  g/mL. Grade 1-2 infusion reactions were seen above the dose of 16 mg, but could be prevented with single-dose corticosteroid premedication. HACA responses were seen after doses between 1.6 mg and 50 mg, but not above this. There were dose-dependent falls in blood B-cell numbers accompanied by reduced expression of @entity7 , and transient reductions in NK cell numbers with increased @entity5 expression from 50 mg upward. @entity8 and IL12 plasma concentrations rose after doses above 16 mg. Fifteen of 29 treatments were accompanied by disease stabilization for a median 6 months, the longest for 37 months. CONCLUSIONS: ChiLob7/4 can activate B and NK cells at doses that can be administered safely, and should be tested in combination with other antibodies and chemotherapy agents. Clin Cancer Res; 21(6); 1321-8.   2015 AACR.

title: Clinical and Biological Effects of an Agonist Anti- XXXX Antibody: A Cancer Research UK Phase I Study.

answer: @entity6


abstract: Invasive diagnosis of @entity1 utilizes either anatomical or functional measurements. In this study, we tested a futuristic parameter, lesion flow coefficient (LFC, defined as the ratio of percent @entity5 (%AS) to the square root of the ratio of the pressure drop across the @entity3 to the dynamic pressure in the throat region), that combines both the anatomical (%AS) and functional measurements (pressure and flow) for application in a clinical setting. In 51 vessels, simultaneous pressure and flow readings were obtained using a 0.014" Combowire (Volcano Corporation). Anatomical details were assessed using quantitative coronary angiography (QCA). Fractional flow reserve (FFR), coronary flow reserve (CFR), @entity3 ( @entity3 ), and hyperemic microvascular index (HMR) were obtained at baseline and @entity4 -induced @entity0 . QCA data were corrected for the presence of guidewire and then the LFC values were calculated. LFC was correlated with FFR, CFR, @entity3 , and HMR, individually and in combination with %AS, under both baseline and hyperemic conditions. Further, in 5 vessels, LFC group mean values were compared between pre-PCI and post-PCI groups. P<.05 was considered statistically significant. LFC measured at @entity0 correlated significantly when the pressure-based FFR, flow-based CFR, and anatomically measured %AS were combined (r = 0.64; P<.05). Similarly, LFC correlated significantly when @entity3 , HMR, and %AS were combined (r = 0.72; P<.05). LFC was able to significantly distinguish between pre-PCI and post-PCI groups (0.42    0.05 and 0.05    0.004, respectively; P<.05). Similar results were obtained for the LFC at baseline conditions. LFC, a futuristic parameter that combines both the anatomical and functional endpoints, has potential for application in a clinical setting for @entity3 evaluation, under both @entity2 .

title: Lesion flow coefficient: a combined anatomical and functional parameter for detection of XXXX - a clinical study.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Few studies have examined collateral formation in @entity0 with @entity1 ( @entity1 ). The aim of this study was to analyse the impact of baseline intracranial venous collaterals on the clinical outcome and imaging features of @entity0 with acute @entity1 . MATERIAL AND METHODS: MRIs from consecutive @entity0 with acute @entity1 were retrospectively analysed. The category system described by Qureshi was used to assess the pattern of venous collaterals. Clinical and imaging features and outcomes were analysed using bivariate and multivariate models to assess the association of collateral patterns with the type of parenchymal lesions and clinical outcome (modified Rankin Scale) at 30 and 90   days. RESULTS: One hundred @entity0 were included (77 @entity0 ; median age 32   years; and median of 18   months of follow-up). @entity5 were present in 88% of the @entity0 ; type I collaterals in 3 @entity0 , type II collaterals in 27 @entity0 , and @entity4 in 58 @entity0 . Twelve @entity0 did not exhibit any collaterals. Cohen's k coefficient between evaluators was 0.86. In the bivariate analysis, @entity4 were associated with isolated intracranial @entity3 and complete recovery, whereas type I collaterals were associated with @entity2 . However, in the multivariate regression analysis, the collateral pattern was not associated with clinical presentation, type of @entity2 or outcome. CONCLUSIONS: Intracranial venous collaterals are frequently found in @entity0 with @entity1 during the acute phase. However, they do not have an independent effect on the type of @entity2 , clinical manifestations or prognosis.

title: Intracranial venous collaterals in XXXX : clinical and imaging impact.

answer: @entity1


abstract: The aim of this work was to evaluate the perfomance of agar-gelatin (AG) composites and AG-containing 45S5 bioactive glass (BG) microparticles (AGBG) in relation to their water uptake capacity, sustained release of a drug over time, and antibacterial effects. The composites were fabricated by the gel-casting method. To impart the local drug release capacity, @entity1 (VC) was loaded in the composites in concentrations of 0.5 and 1   mg   ml(-1). VC release was assessed in distilled water at 37     C up to 72   h and quantified spectrophotometrically. The antibacterial activity of composites was evaluated by the inhibition zone test and the plate count method. The experiments were performed in vitro up to 48   h on three @entity0 strains: @entity0 ATCC29213, @entity0 ATCC6538 and @entity3 . The results showed that the addition of BG to AG composites did not affect the degree of water uptake. The release of VC was significantly affected by the presence of BG. VC release was higher from AGBGVC films than from AGVC ones over prolonged incubation times. Bacterial inhibition zones were found around the composites. The halos were larger when the cells were put in contact with AGVC composites than when they were put in contact with AGBGVC ones. Nevertheless, the viable count method demonstrated that the composites inhibited @entity0 cell growth with no statistical differences. In conclusion, the addition of BG did not reflect an improvement in the parameters studied. On the other hand, composites loaded with VC would have a role in prophylaxis against @entity2 .

title: Evaluation of the antibacterial effects of XXXX released from agar-gelatin-bioactive glass composites.

answer: @entity1


abstract: BACKGROUND: Patellofemoral instability and dysfunction are frequent symptoms in @entity4 ( @entity4 ). In this article, the first large series of @entity4 @entity0 is presented in which these knee symptoms were assessed using validated outcome scores. Additionally, the need for surgical interventions, percentage of @entity0 who received surgical treatment and @entity0 reported outcomes are reported. METHODS: A questionnaire based survey was conducted in 139 Dutch @entity4 @entity0 . Symptoms of the knees were assessed by the @entity3 and @entity2 Outcome Score (KOOS) and Kujala knee score. The questionnaire addressed whether surgical intervention was currently considered, history of past surgeries, type of surgical procedures performed and results of these procedures. RESULTS: Response rate was 74%. Mean KOOS (73.04) and Kujala (74.01) scores showed a wide range and variability between @entity0 . Patellofemoral instability was present in 48.5% of @entity0 . Surgical intervention was currently considered by 12% of @entity0 . Their KOOS and Kujala scores were significantly lower compared to those not considering surgery and they experienced more patellar instability. Surgery was performed on 31 knees in 23 @entity0 . KOOS and Kujala scores were lower in surgically treated versus nonoperated @entity0 but no difference in patellar instability was present. An improvement in @entity1 in 87% and in function in 30% of knees was reported after surgery. @entity0 satisfaction with the surgical results was 61% and 10% was dissatisfied. Patellar realignment procedures showed similar results, although persistent patellar instability was reported in 40% of @entity0 , not different from nonoperated @entity0 . CONCLUSIONS: Knee symptoms in @entity4 @entity0 vary widely, with patellar instability present in nearly half of the @entity0 . Although surgical treatment appears unfavourable as surgically treated @entity0 have lower KOOS and Kujala scores, the @entity0 reported surgical results are generally good with a high @entity0 satisfaction. LEVEL OF EVIDENCE: Level IV.

title: XXXX : Knee symptoms and surgical outcomes. A questionnaire-based survey.

answer: @entity4


abstract: For an increasing number of @entity1 @entity0 , bariatric surgery is considered as the treatment of choice after the failure of conventional strategies. While numerous studies on bariatric surgery have shown substantial health benefits, there is a broad inter-individual variation in the long-term outcome, which is insufficiently understood. Here we show a favourable long-term outcome following multidisciplinary care in a @entity3 @entity0 . The @entity0 suffered from numerous typically @entity1 -associated comorbidities and limitations. He underwent multidisciplinary care including two-step bariatric intervention. Endoscopic intragastric balloon positioning was followed by @entity2 without Roux-en-Y gastric bypass. His body weight dropped from 260   kg (body mass index [BMI] 79.4   kg   m(-2) ) to 85   kg (BMI 25.9   kg   m(-2) ) within 16 months and continued to be stable at 90   kg (BMI 27.8   kg   m(-2) ) at the end of the follow-up period of 48 months. The loss of excess body weight was associated with the remission of numerous @entity1 -related comorbidities and with a concomitant pronounced increase in the quality of life and in the socioeconomic status. Eventually, the @entity0 was able to lead a normal life with a decreased risk of long-term complications. We attribute the positive long-term outcome to the following potential determinants: individualized bariatric surgery, multidisciplinary care, the @entity0 's long-term compliance, adequate adherence to the aftercare, physical exercise after surgery, family support, the cooperation of the primary care physician and the financial coverage by the health insurance. Some of these factors remain to be evaluated as predictors of a favourable long-term outcome in prospective trials.

title: A model case of a positive outcome in super-super XXXX .

answer: @entity1


abstract: OBJECTIVES: To examine the relationships between executive functioning, coping, @entity2 , and quality of life in individuals with @entity1 after acquired @entity4 (ABI). DESIGN: Cross-sectional study. METHODS: Individuals (n  =  93) in the post-acute and chronic phase (>3  months) after ABI and their significant others (N  =  58) were recruited from outpatient clinics of four mental health centres in the Netherlands. Outcome measures were the @entity5 Making Test, Stroop Colour Word Test, Frontal Systems Behavioural Scale, Utrecht Coping List, @entity0 Health Questionnaire, and Life Satisfaction Questionnaire. Data were analysed with multiple regression analyses. RESULTS: Self-reported @entity3 was associated with greater use of passive coping styles (b  =  .37, p  <  .01), and passive coping, in turn, was associated with lower quality of life (b  =  -.57, p  <  .001) and more @entity2 (b  =  .65, p  <  .001). Problem-focused coping was associated with higher quality of life among individuals who reported better executive functioning (b  =  -.94, p  <  .05). Performances on executive functioning tests were not associated with coping, @entity2 , or quality of life. CONCLUSIONS: For clinicians, these data indicate that individuals who report greater difficulties with executive functioning after ABI are inclined to use maladaptive passive coping styles, which should be targeted in treatment. In comparison, individuals who report greater difficulties with executive functioning should not be prompted to use problem-focused coping styles. These individuals may benefit from other coping styles, such as the use of seeking social support or acceptance of problems. PRACTITIONER POINTS: Coping influences the association between executive functioning and quality of life. Individuals who report difficulties with executive functioning after ABI may be inclined to use passive coping styles, which are maladaptive. Problem-focused coping strategies may be more useful for individuals who have strong executive abilities. This study was a cross-sectional study; thus, a cause-and-effect relationship could not be established between executive functioning, coping, and psychosocial functioning. As this research was part of standard clinical care, non-traditional tests for executive functioning were not administered.

title: Associations between executive functioning, coping, and psychosocial functioning after acquired XXXX .

answer: @entity4


abstract: Background/Aims. Studies on 46,XY @entity4 ( @entity4 ) have focused on molecular, gonadal, genital, and hormone features; little is known about follow-up. Our aim was to analyze long-term outcomes of @entity4 . Methods. Retrospective longitudinal study conducted at a reference service in Brazil. Ten @entity0 were first evaluated in the 1990s and followed up until the 2010s; follow-up ranged from 13.5 to 19.7 years. All were reared as males and had at least one scrotal testis; two bore @entity6 mutations. Main outcomes were: associated conditions, pubertal development, and growth. Results. All @entity0 had normal motor development but three presented @entity1 ; five had various associated conditions. At the end of the prepubertal period, FSH was high or high-normal in 3/6 @entity0 ; LH was normal in all. At the last evaluation, FSH was high or high-normal in 8/10; LH was high or high-normal in 5/10; @entity2 was decreased in one. Final height in nine cases ranged from -1.57 to 0.80   SDS. All had spontaneous puberty; only one needed @entity3 therapy. Conclusions. There is good prognosis for growth and spontaneous pubertal development but not for fertility. Though additional studies are required, screening for @entity5 is advisable.

title: Long-Term Follow-Up of XXXX with 46,XY Partial Gonadal Dysgenesis Reared as Males.

answer: @entity0


abstract: BACKGROUND: The @entity3 variant III deletion mutation, EGFRvIII, is expressed in    30% of @entity2 and linked to poor long-term survival. Rindopepimut consists of the unique EGFRvIII peptide sequence conjugated to keyhole limpet hemocyanin. In previous phase II trials (ACTIVATE/ACT II), rindopepimut was well tolerated with robust EGFRvIII-specific immune responses and promising progression-free and overall survival. This multicenter, single-arm phase II clinical trial (ACT III) was performed to confirm these results. METHODS: Rindopepimut and standard adjuvant @entity4 chemotherapy were administered to 65 @entity0 with newly diagnosed EGFRvIII-expressing (EGFRvIII+) @entity2 after gross total resection and chemoradiation. RESULTS: Progression-free survival at 5.5 months (   8.5 mo from diagnosis) was 66%. Relative to study entry, median overall survival was 21.8 months, and 36-month overall survival was 26%. Extended rindopepimut vaccination (up to 3.5+ years) was well tolerated. Grades 1-2 injection site reactions were frequent. Anti-EGFRvIII antibody titers increased >= 4-fold in 85% of @entity0 , and increased with duration of treatment. EGFRvIII was eliminated in 4/6 (67%) @entity1 samples obtained after >3 months of therapy. CONCLUSIONS: This study confirms, in a multicenter setting, the preliminary results seen in previous phase II trials of rindopepimut. A pivotal, double-blind, randomized, phase III trial ("ACT IV") is under way.

title: A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed XXXX : the ACT III study.

answer: @entity2


abstract: BACKGROUND: Natriuretic peptides and @entity5 ( @entity5 ) represent two different physiopathological pathways. We evaluated the prognostic accuracy and complementarity of @entity4 ( @entity4 ) and soluble @entity5 (sST2) plasma levels at discharge from a hospital admission for @entity3 , both in @entity0 with preserved (HFpEF) and @entity2 (HFrEF) systolic function. METHODS AND RESULTS: We enrolled 195 consecutive @entity0 discharged alive and followed them prospectively for 6  months. The endpoint was all-cause @entity1 or hospital readmission for @entity3 . Seventy-six @entity0 had HFpEF and 119 had HFrEF, of whom 23 (30.3  %) and 43 (36.1  %) reached the combined endpoint, respectively. In both HFpEF and HFrEF, having the two biomarkers into account added prognostic information, with the highest risk in @entity0 with both biomarkers above the median in their group (approximately 40  % hospitalization-free survival in both groups at 6  months). These associations translated into a significant fourfold increase in risk of the endpoint for one elevated biomarker and sevenfold for both biomarkers elevated in HFrEF, and no association for one elevated biomarker and fivefold increase in risk for both biomarkers elevated in HFpEF. Considering the reclassification of risk added to @entity4 by measurement of sST2, net reclassification index was 0.31 (p  =  0.21) among @entity0 with HFpEF and 0.70 (p  <  0.001) among @entity0 with HFrEF. CONCLUSIONS: sST2 provides robust prognostic information in @entity3 with HFrEF, while this pattern was less clear in HFpEF. When sST2 was measured together with @entity4 , it improved prognostic accuracy in both groups, more clearly in HFrEF.

title: Prognostic value of sST2 added to @entity4 in XXXX with preserved or reduced ejection fraction.

answer: @entity3


abstract: BACKGROUND: Natriuretic peptides and @entity5 ( @entity5 ) represent two different physiopathological pathways. We evaluated the prognostic accuracy and complementarity of @entity4 ( @entity4 ) and soluble @entity5 (sST2) plasma levels at discharge from a hospital admission for @entity3 , both in @entity0 with preserved (HFpEF) and @entity2 (HFrEF) systolic function. METHODS AND RESULTS: We enrolled 195 consecutive @entity0 discharged alive and followed them prospectively for 6  months. The endpoint was all-cause @entity1 or hospital readmission for @entity3 . Seventy-six @entity0 had HFpEF and 119 had HFrEF, of whom 23 (30.3  %) and 43 (36.1  %) reached the combined endpoint, respectively. In both HFpEF and HFrEF, having the two biomarkers into account added prognostic information, with the highest risk in @entity0 with both biomarkers above the median in their group (approximately 40  % hospitalization-free survival in both groups at 6  months). These associations translated into a significant fourfold increase in risk of the endpoint for one elevated biomarker and sevenfold for both biomarkers elevated in HFrEF, and no association for one elevated biomarker and fivefold increase in risk for both biomarkers elevated in HFpEF. Considering the reclassification of risk added to @entity4 by measurement of sST2, net reclassification index was 0.31 (p  =  0.21) among @entity0 with HFpEF and 0.70 (p  <  0.001) among @entity0 with HFrEF. CONCLUSIONS: sST2 provides robust prognostic information in @entity3 with HFrEF, while this pattern was less clear in HFpEF. When sST2 was measured together with @entity4 , it improved prognostic accuracy in both groups, more clearly in HFrEF.

title: Prognostic value of sST2 added to XXXX in @entity3 with preserved or reduced ejection fraction.

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity4 ), previously known as Minimal @entity4 , is a subtle @entity1 found in 30-70  % of @entity3 @entity0 . It has been linked to poor quality of life, @entity5 to drive, and increased mortality: treatment is possible. Despite its clinical significance, diagnosis relies on psychometric tests that have proved unsuitable for use in a clinical setting. We investigated whether measurement of saccadic latency distributions might be a viable alternative. We collected data on 35 @entity3 @entity0 at Addenbrooke's Hospital, Cambridge, with no evidence of clinically overt @entity2 , and 36 age-matched healthy controls. Performance on standard psychometric tests was evaluated to determine those @entity0 with @entity4 as defined by the World Congress of Gastroenterology. We then compared visually-evoked saccades between those with @entity4 and those without, as well as reviewing blood test results and correlating saccadic latencies with biochemical parameters and prognostic scores. @entity3 @entity0 have significantly longer median saccadic latencies than healthy controls. Those with @entity4 had significantly prolonged saccadic latencies when compared with those without @entity4 . Analysis of a @entity3 @entity0 's saccades can diagnose @entity4 with a sensitivity of 75  % and a specificity of 75  %. We concluded that analysis of a @entity3 @entity0 's saccadic latency distributions is a fast and objective measure that can be used as a diagnostic tool for @entity4 . This improved early diagnosis could direct avoidance of high-risk activities such as driving, and better inform treatment strategies.

title: Using saccades to diagnose covert hepatic XXXX .

answer: @entity2


abstract: BACKGROUND: Anaphylaxis is an acute, @entity7 that results from the sudden release of mast cell- and basophil-derived mediators. Although @entity6 can cause @entity2 , the incidence of @entity1 using troponin I (TnI) has not been characterized. In addition, patterns of @entity1 have not been evaluated in @entity0 with elevated TnI. Therefore, we studied the occurrence and patterns of @entity1 with TnI and echocardiography in @entity6 . METHODS: We conducted a retrospective review of 300 consecutive @entity6 cases that were diagnosed in the @entity3 ( @entity3 ) over 53 months (2011-2015). @entity1 was defined as elevation of TnI within 24hrs after arrival at the @entity3 . We investigated systolic function and regional wall motion abnormality (RWMA) through echocardiography within 5 hours after arrival at the @entity3 in @entity0 with @entity1 . RESULTS: Among 300 @entity0 (median age, 55 years), 22 @entity0 demonstrated @entity1 (7.3%). The median TnI was 0.222 ng/mL with a range from 0.057 ng/mL to 19.4 ng/mL. Three @entity0 presented reduced systolic function and 4 @entity0 showed RWMA. One @entity0 showed reverse @entity4 and other 2 @entity0 had RWMA discordant to the distribution of coronary arteries. Another @entity0 showed RWMA (inferior wall) with ST elevation of II, III, and aVF. All 4 @entity0 were discharge after recovery of @entity1 without any specific intervention for @entity1 . CONCLUSIONS: @entity1 developed in 7.3% of @entity0 with @entity6 . Various @entity1 , including @entity5 and @entity4 , has been observed in @entity0 with @entity1 .

title: Evaluation of XXXX through serum troponin I and echocardiography in @entity6 .

answer: @entity1


abstract: BACKGROUND: Anaphylaxis is an acute, @entity7 that results from the sudden release of mast cell- and basophil-derived mediators. Although @entity6 can cause @entity2 , the incidence of @entity1 using troponin I (TnI) has not been characterized. In addition, patterns of @entity1 have not been evaluated in @entity0 with elevated TnI. Therefore, we studied the occurrence and patterns of @entity1 with TnI and echocardiography in @entity6 . METHODS: We conducted a retrospective review of 300 consecutive @entity6 cases that were diagnosed in the @entity3 ( @entity3 ) over 53 months (2011-2015). @entity1 was defined as elevation of TnI within 24hrs after arrival at the @entity3 . We investigated systolic function and regional wall motion abnormality (RWMA) through echocardiography within 5 hours after arrival at the @entity3 in @entity0 with @entity1 . RESULTS: Among 300 @entity0 (median age, 55 years), 22 @entity0 demonstrated @entity1 (7.3%). The median TnI was 0.222 ng/mL with a range from 0.057 ng/mL to 19.4 ng/mL. Three @entity0 presented reduced systolic function and 4 @entity0 showed RWMA. One @entity0 showed reverse @entity4 and other 2 @entity0 had RWMA discordant to the distribution of coronary arteries. Another @entity0 showed RWMA (inferior wall) with ST elevation of II, III, and aVF. All 4 @entity0 were discharge after recovery of @entity1 without any specific intervention for @entity1 . CONCLUSIONS: @entity1 developed in 7.3% of @entity0 with @entity6 . Various @entity1 , including @entity5 and @entity4 , has been observed in @entity0 with @entity1 .

title: Evaluation of @entity1 through serum troponin I and echocardiography in XXXX .

answer: @entity6


abstract: BACKGROUND: The techniques of intracorporeal anastomosis and specimen extraction after laparoscopic colectomy via a natural orifice have gained interest increasingly. We evaluated the feasibility of our unique techniques for colorectal reconstruction and report immediate postoperative outcomes in @entity0 with @entity1 . METHODS: @entity0 with sigmoid or @entity1 were selected depending on the size of the @entity1 and its distance from the anal verge. Demographic data, operative parameters, and postoperative outcomes were assessed. After complete resection of the @entity1 , all @entity0 underwent an intracorporeal side-to-end colorectal anastomosis following transrectal specimen extraction. RESULTS: Laparoscopic resection with our technique of intracorporeal anastomosis was successful in 32 @entity0 . The average operative time was 192      29  min, and mean @entity2 was 51      18  ml. All @entity0 experienced mild @entity3 , and bowel function returned before postoperative day 3 in most @entity0 . They had an uneventful postoperative course with a median hospital stay of 6  days. Major perioperative complications or @entity4 were not encountered in this study. The mean size of the lesion was 3.3      1.8  cm, and the mean number of harvested nodes was 14      6. During the follow-up period, there were no functional disorders associated with the intracorporeal anastomosis or transrectal specimen extraction. CONCLUSIONS: Intracorporeal side-to-end colorectal anastomosis with transrectal specimen extraction in laparoscopic colorectal surgery is a safe and effective procedure for @entity0 with @entity1 .

title: Totally Laparoscopic Colectomy with Intracorporeal Side-to-End Colorectal Anastomosis and Transrectal Specimen Extraction for Sigmoid and XXXX .

answer: @entity1


abstract: STUDY DESIGN: Case report and review of literature. OBJECTIVE: To present an exceedingly rare occurrence of obstructive @entity4 ( @entity4 ) secondary to @entity1 ( @entity1 ) after incidental durotomy during lumbar spine surgery. SUMMARY OF BACKGROUND DATA: Incidental durotomies are uncommon but well recognized complications associated with spine surgery. While mostly considered benign with no untoward clinical sequele, it can be symptomatic and present with spinal headaches, pseudomeningoceles, @entity6 , @entity2 and @entity5 . METHODS: A 76-year-old @entity0 underwent L3-S1 laminectomies and fusion for @entity7 and @entity3 . Intraoperatively, a small incidental durotomy was encountered and primarily repaired. RESULTS: The @entity0 developed altered mental status on post-operative day 2. Computed tomography of the brain revealed obstructive @entity4 and @entity1 . The @entity0 was immediately transferred to the neurosurgery intensive care unit and an external ventricular drain (EVD) was placed emergently with high opening pressure. Her mental status improved immediately after cerebral spinal fluid diversion. The EVD was successfully removal after 8 days. The @entity0 made a full recovery and was discharged in stable condition. CONCLUSIONS: Obstructive @entity4 following @entity1 is an exceptionally rare but potentially life-threatening complication of incidental durotomies. Spine surgeons should be aware of this rare but serious complication.

title: @entity4 Due to Intraventricular XXXX Following Incidental Durotomy during Lumbar Spine Surgery.

answer: @entity1


abstract: STUDY DESIGN: Case report and review of literature. OBJECTIVE: To present an exceedingly rare occurrence of obstructive @entity4 ( @entity4 ) secondary to @entity1 ( @entity1 ) after incidental durotomy during lumbar spine surgery. SUMMARY OF BACKGROUND DATA: Incidental durotomies are uncommon but well recognized complications associated with spine surgery. While mostly considered benign with no untoward clinical sequele, it can be symptomatic and present with spinal headaches, pseudomeningoceles, @entity6 , @entity2 and @entity5 . METHODS: A 76-year-old @entity0 underwent L3-S1 laminectomies and fusion for @entity7 and @entity3 . Intraoperatively, a small incidental durotomy was encountered and primarily repaired. RESULTS: The @entity0 developed altered mental status on post-operative day 2. Computed tomography of the brain revealed obstructive @entity4 and @entity1 . The @entity0 was immediately transferred to the neurosurgery intensive care unit and an external ventricular drain (EVD) was placed emergently with high opening pressure. Her mental status improved immediately after cerebral spinal fluid diversion. The EVD was successfully removal after 8 days. The @entity0 made a full recovery and was discharged in stable condition. CONCLUSIONS: Obstructive @entity4 following @entity1 is an exceptionally rare but potentially life-threatening complication of incidental durotomies. Spine surgeons should be aware of this rare but serious complication.

title: XXXX Due to Intraventricular @entity1 Following Incidental Durotomy during Lumbar Spine Surgery.

answer: @entity4


abstract: BACKGROUND AND OBJECTIVES: Improvements in agricultural practices in Croatia have reduced exposure to consumption of @entity5 -contaminated flour and development of endemic (Balkan) @entity2 . Therefore, it was hypothesized that Bosnian immigrants who settled in an endemic area in Croatia 15-30 years ago would be at lower risk of developing endemic @entity2 because of reduced exposure to @entity5 . To test this hypothesis, past and present exposure to @entity5 , proximal tubule damage as a hallmark of endemic @entity2 , and prevalence of CKD in Bosnian immigrants were analyzed. DESIGN, SETTING, @entity0 , _ MEASUREMENTS: In this cross-sectional observational study from 2005 to 2010, 2161 farmers were divided into groups: indigenous inhabitants from endemic @entity2 and nonendemic @entity2 villages and Bosnian immigrants; a-1 microglobulin-to- @entity3 ratio >31.5 mg/g and eGFR<60 ml/min per 1.73 m(2) were considered to be abnormal. RESULTS: CKD and proximal tubule damage prevalence was significantly lower in Bosnian immigrants than inhabitants of @entity2 (6.9% versus 16.6%; P<0.001; 1.3% versus 7.3%; P=0.003, respectively); 20 years ago, Bosnian immigrants observed fewer Aristolochia clematitis in cultivated fields (41.9% versus 67.8%) and fewer seeds among @entity4 seeds (6.1% versus 35.6%) and ate more purchased than homemade bread compared with Croatian farmers from @entity2 (38.5% versus 14.8%, P<0.001). Both Croatian farmers and Bosnian immigrants observe significantly fewer Aristolochia plants growing in their fields compared with 15-30 years ago. Prior @entity5 exposure was associated with proximal tubule damage (odds ratio, 1.64; 95% confidence interval, 1.04 to 2.58; P=0.02), whereas present exposure was not (odds ratio, 1.31; 95% confidence interval, 0.75 to 2.30; P=0.33). Furthermore, immigrant status was an independent negative predictor of proximal tubule damage (odds ratio, 0.40; 95% confidence interval, 0.19 to 0.86; P=0.02). CONCLUSIONS: Bosnian immigrants and autochthonous Croats residing in endemic areas are exposed significantly less to ingestion of @entity5 than in the past. The prevalence of endemic @entity2 and its associated @entity1 is predicted to decrease over time.

title: Chronic dietary exposure to XXXX and kidney function in native farmers from a croatian endemic area and bosnian immigrants.

answer: @entity5


abstract: UNASSIGNED: PKA plays a critical role in water excretion through regulation of the production and action of the antidiuretic hormone, arginine vasopressin (AVP). The AVP prohormone is produced in the hypothalamus where its transcription is regulated by cAMP. Once released into circulation, AVP stimulates antidiuresis through activation of vasopressin 2 receptors ( @entity6 ) in renal principal cells. V2R activation increases cAMP and activates PKA, which in turn phosphorylates @entity5 , triggering apical membrane accumulation, increased collecting duct permeability and water reabsorption. We used @entity7 -Cre-mediated expression of a dominant-negative PKA regulatory subunit (RIaB) to disrupt kinase activity in vivo and assess the role of PKA in fluid homeostasis. RIaB expression gave rise to marked @entity4 and @entity2 ; however, neither hypothalamic Avp mRNA expression nor urinary AVP levels were attenuated, indicating a primary physiological effect on the kidney. RIaB @entity0 displayed a marked deficit in urinary concentrating ability and greatly reduced levels of @entity5 and phospho- @entity5 . @entity3 induced @entity5 mRNA in the kidney of both control and RIaB-expressing @entity0 , but @entity5 protein levels were still reduced in RIaB-expressing mutants and the @entity0 are unable to fully concentrate their urine and conserve water. We conclude that partial PKA inhibition in kidney leads to post-translational effects that reduce @entity5 protein levels, and interfere with apical membrane localization. These findings demonstrate a distinct physiological role for PKA signaling in both short- and long-term regulation of @entity5 and characterize a novel @entity0 model of @entity1 .

title: Expression of a dominant negative Protein Kinase A (PKA) mutation in kidney elicits a XXXX phenotype.

answer: @entity1


abstract: @entity2 ( @entity2 ) frequently leads to generalized @entity1 and gait disturbances which cause serious discomfort among @entity0 . @entity0 gait is a complex process in the central nervous system that results from the integration of various mechanisms which remain unclear. Therefore, it is of great theoretical and practical significance to investigate the cortical activity patterns during gait movement in @entity2 . In this study, brain activity was recorded by electroencephalogram (EEG) during two kinds of gait-like movements. Phase synchronization between motor cortices was investigated through source analysis and phase locking. Results revealed that diverse neural networks with different resonance-like frequencies exist in the brain. Further, we found that the premotor cortex played an important role in the control of @entity1 . In attempted/active movement, spatial function and multimodal integration with somatosensory information are crucial aspects of posterior parietal cortex function which need to be considered separately in different EEG bands. Our results further confirmed that neural system control patterns in @entity1 differ from those in attempted or active gait-like movement. Novel insights into @entity0 gait will provide a basis for improvements in future neurorehabilitation applications.

title: Phase Synchronization Between Motor Cortices During Gait Movement in @entity0 With XXXX .

answer: @entity2


abstract: @entity2 ( @entity2 ) frequently leads to generalized @entity1 and gait disturbances which cause serious discomfort among @entity0 . @entity0 gait is a complex process in the central nervous system that results from the integration of various mechanisms which remain unclear. Therefore, it is of great theoretical and practical significance to investigate the cortical activity patterns during gait movement in @entity2 . In this study, brain activity was recorded by electroencephalogram (EEG) during two kinds of gait-like movements. Phase synchronization between motor cortices was investigated through source analysis and phase locking. Results revealed that diverse neural networks with different resonance-like frequencies exist in the brain. Further, we found that the premotor cortex played an important role in the control of @entity1 . In attempted/active movement, spatial function and multimodal integration with somatosensory information are crucial aspects of posterior parietal cortex function which need to be considered separately in different EEG bands. Our results further confirmed that neural system control patterns in @entity1 differ from those in attempted or active gait-like movement. Novel insights into @entity0 gait will provide a basis for improvements in future neurorehabilitation applications.

title: Phase Synchronization Between Motor Cortices During Gait Movement in XXXX With @entity2 .

answer: @entity0


abstract: UNASSIGNED: Small non-coding RNAs named microRNAs (miRNAs) modulate some functions and signaling pathways in skin epithelial cells and melanocytes. They also function as oncogenes or @entity1 suppressors in @entity1 and @entity1 @entity0 . We investigated the expression patterns of miRNAs, including @entity3 , 21, 200c, 373 and 520c, which regulate epithelial-to-mesenchymal transition (EMT) and @entity0 in @entity1 stem cells (CSCs) and non- CSCs. Six @entity2 cell lines were tested for the expressions of stem cell markers. @entity2 stem cells were enriched via fluorescence-activated cell sorting (FACS) using the CD133 cell surface marker or spheroid culture. They were then characterized based on colony and sphere formation, and the expressions of stemness and EMT regulator genes and their invasion potential were assessed using real-time qRT-PCR and invasion assay. Our results indicate that cells enriched via sphere formation expressed all the stemness-related genes and had an enhanced number of colonies, spheres and invaded cells compared to cells enriched using the CD133 cell surface marker. Moreover, miRNAs controlling @entity0 increased in the melanospheres. This may be related to the involvement of CSCs in the metastatic process. However, this must be further confirmed through the application of knockdown experiments. The results show that sphere formation is a useful method for enriching @entity2 stem cells. Melanospheres were found to upregulate @entity3 , 21, 200c, 373 and 520c, so we suggest that they may control both @entity0 and stemness potential.

title: Evaluation of the expressions pattern of @entity3 , 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and XXXX stem cell potential in @entity1 stem cells.

answer: @entity2


abstract: UNASSIGNED: Small non-coding RNAs named microRNAs (miRNAs) modulate some functions and signaling pathways in skin epithelial cells and melanocytes. They also function as oncogenes or @entity1 suppressors in @entity1 and @entity1 @entity0 . We investigated the expression patterns of miRNAs, including @entity3 , 21, 200c, 373 and 520c, which regulate epithelial-to-mesenchymal transition (EMT) and @entity0 in @entity1 stem cells (CSCs) and non- CSCs. Six @entity2 cell lines were tested for the expressions of stem cell markers. @entity2 stem cells were enriched via fluorescence-activated cell sorting (FACS) using the CD133 cell surface marker or spheroid culture. They were then characterized based on colony and sphere formation, and the expressions of stemness and EMT regulator genes and their invasion potential were assessed using real-time qRT-PCR and invasion assay. Our results indicate that cells enriched via sphere formation expressed all the stemness-related genes and had an enhanced number of colonies, spheres and invaded cells compared to cells enriched using the CD133 cell surface marker. Moreover, miRNAs controlling @entity0 increased in the melanospheres. This may be related to the involvement of CSCs in the metastatic process. However, this must be further confirmed through the application of knockdown experiments. The results show that sphere formation is a useful method for enriching @entity2 stem cells. Melanospheres were found to upregulate @entity3 , 21, 200c, 373 and 520c, so we suggest that they may control both @entity0 and stemness potential.

title: Evaluation of the expressions pattern of @entity3 , 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and @entity2 stem cell potential in XXXX stem cells.

answer: @entity1


abstract: UNASSIGNED: Small non-coding RNAs named microRNAs (miRNAs) modulate some functions and signaling pathways in skin epithelial cells and melanocytes. They also function as oncogenes or @entity1 suppressors in @entity1 and @entity1 @entity0 . We investigated the expression patterns of miRNAs, including @entity3 , 21, 200c, 373 and 520c, which regulate epithelial-to-mesenchymal transition (EMT) and @entity0 in @entity1 stem cells (CSCs) and non- CSCs. Six @entity2 cell lines were tested for the expressions of stem cell markers. @entity2 stem cells were enriched via fluorescence-activated cell sorting (FACS) using the CD133 cell surface marker or spheroid culture. They were then characterized based on colony and sphere formation, and the expressions of stemness and EMT regulator genes and their invasion potential were assessed using real-time qRT-PCR and invasion assay. Our results indicate that cells enriched via sphere formation expressed all the stemness-related genes and had an enhanced number of colonies, spheres and invaded cells compared to cells enriched using the CD133 cell surface marker. Moreover, miRNAs controlling @entity0 increased in the melanospheres. This may be related to the involvement of CSCs in the metastatic process. However, this must be further confirmed through the application of knockdown experiments. The results show that sphere formation is a useful method for enriching @entity2 stem cells. Melanospheres were found to upregulate @entity3 , 21, 200c, 373 and 520c, so we suggest that they may control both @entity0 and stemness potential.

title: Evaluation of the expressions pattern of XXXX , 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and @entity2 stem cell potential in @entity1 stem cells.

answer: @entity3


abstract: Forty @entity0 with terminal @entity1 and 40 @entity0 with @entity5 -all consecutively admitted-were studied with regard to incidence, types, and prognosis of complicating @entity2 . @entity2 was considered present when the serum @entity6 was greater than 0.20 mmol/l. Of the @entity0 with @entity1 26 (65%) developed @entity2 . In 15 the type was functional, in three due to @entity7 , and in eight indeterminable. Of the @entity0 with @entity5 (55%) had @entity2 ; of these 13 had functional @entity2 , five @entity7 , and in four the type was indeterminable. In both categories of @entity0 , @entity2 was equally frequent among @entity0 with or without @entity3 and with or without @entity4 or diuretic therapy. The biochemical tests of liver function were similar in @entity0 with or without @entity2 in both categories. The mean renal blood flow in seven unselected @entity0 with @entity5 was reduced in the same order as previously observed in @entity0 with @entity1 . In terminal @entity1 the mortality rate was 88% in the presence of @entity2 , 71% in its absence (p greater than 0.05), while the same figures in @entity5 were 100% and 67% (p less than 0.05). The incidence, relative frequency, and prognosis of @entity2 were not different in the two conditions, indicating identical pathophysiological circumstances.

title: @entity2 in @entity5 and terminal XXXX : a comparison between incidence, types, and prognosis.

answer: @entity1


abstract: Forty @entity0 with terminal @entity1 and 40 @entity0 with @entity5 -all consecutively admitted-were studied with regard to incidence, types, and prognosis of complicating @entity2 . @entity2 was considered present when the serum @entity6 was greater than 0.20 mmol/l. Of the @entity0 with @entity1 26 (65%) developed @entity2 . In 15 the type was functional, in three due to @entity7 , and in eight indeterminable. Of the @entity0 with @entity5 (55%) had @entity2 ; of these 13 had functional @entity2 , five @entity7 , and in four the type was indeterminable. In both categories of @entity0 , @entity2 was equally frequent among @entity0 with or without @entity3 and with or without @entity4 or diuretic therapy. The biochemical tests of liver function were similar in @entity0 with or without @entity2 in both categories. The mean renal blood flow in seven unselected @entity0 with @entity5 was reduced in the same order as previously observed in @entity0 with @entity1 . In terminal @entity1 the mortality rate was 88% in the presence of @entity2 , 71% in its absence (p greater than 0.05), while the same figures in @entity5 were 100% and 67% (p less than 0.05). The incidence, relative frequency, and prognosis of @entity2 were not different in the two conditions, indicating identical pathophysiological circumstances.

title: XXXX in @entity5 and terminal @entity1 : a comparison between incidence, types, and prognosis.

answer: @entity2


abstract: Forty @entity0 with terminal @entity1 and 40 @entity0 with @entity5 -all consecutively admitted-were studied with regard to incidence, types, and prognosis of complicating @entity2 . @entity2 was considered present when the serum @entity6 was greater than 0.20 mmol/l. Of the @entity0 with @entity1 26 (65%) developed @entity2 . In 15 the type was functional, in three due to @entity7 , and in eight indeterminable. Of the @entity0 with @entity5 (55%) had @entity2 ; of these 13 had functional @entity2 , five @entity7 , and in four the type was indeterminable. In both categories of @entity0 , @entity2 was equally frequent among @entity0 with or without @entity3 and with or without @entity4 or diuretic therapy. The biochemical tests of liver function were similar in @entity0 with or without @entity2 in both categories. The mean renal blood flow in seven unselected @entity0 with @entity5 was reduced in the same order as previously observed in @entity0 with @entity1 . In terminal @entity1 the mortality rate was 88% in the presence of @entity2 , 71% in its absence (p greater than 0.05), while the same figures in @entity5 were 100% and 67% (p less than 0.05). The incidence, relative frequency, and prognosis of @entity2 were not different in the two conditions, indicating identical pathophysiological circumstances.

title: @entity2 in XXXX and terminal @entity1 : a comparison between incidence, types, and prognosis.

answer: @entity5


abstract: UNASSIGNED: @entity3 ( @entity3 ) arises from the upper aerodigestive tract and is the six most common @entity2 worldwide. @entity3 is associated with high morbidity and mortality, as standard surgery, radiation, and chemotherapy can cause significant disfigurement and only provide 5-year survival rates of ~50-60%. The heterogeneity of @entity3 subsets with different potentials for recurrence and @entity1 challenges the traditional pathological classification system, thereby increasing demand for the development of new diagnostic, prognostic, and therapeutic tools based on global molecular signatures of @entity3 . Historically, using classical biological techniques, it has been extremely difficult and time-consuming to survey hundreds or thousands of genes in a given disease. However, the development of high throughput technologies and high-powered computation throughout the last two decades has enabled us to investigate hundreds or thousands of genes simultaneously. Using high throughput technologies, our laboratory has identified the gene signatures and protein networks, which significantly affect @entity3 malignant phenotypes, including @entity7 / @entity12 / @entity15 family members, @entity8 / @entity13 /NF-kB, PI3K/ @entity5 / @entity10 , @entity6 / @entity17 /JAK/ @entity11 , @entity4 /MAPK/ @entity18 , @entity19 / @entity9 / @entity14 , and TGFb/TGFbR/ @entity16 /SMAD pathways. This review summarizes the results from high-throughput technological assays conducted on @entity3 samples, including microarray, DNA methylation, miRNA profiling, and protein array, using primarily experimental data and conclusions generated in our own laboratory. The use of bioinformatics and integrated analyses of data sets from different platforms, as well as meta-analysis of large datasets pulled from multiple publicly available studies, provided significantly higher statistical power to extract biologically relevant information. The data suggested that the heterogeneity of @entity3 genotype and phenotype are much more complex than we previously thought. Understanding of global molecular signatures and disease classification for specific subsets of @entity3 will be essential to provide accurate diagnoses for targeted therapy and personalized treatment, which is an important effort toward improving @entity0 outcomes.

title: Signaling Networks of Activated Oncogenic and Altered XXXX Suppressor Genes in Head and Neck Cancer.

answer: @entity2