abstract: BACKGROUND: @entity5 , a commonly used sedative in @entity0 during noninvasive diagnostic procedures, is associated with side effects like prolonged sedation, paradoxical excitement, @entity2 , and unpleasant taste. @entity3 , a highly selective a-2 agonist, has better pharmacokinetic properties than @entity5 . We conducted this prospective, double-blind, randomized controlled trial to evaluate efficacy of intranasal @entity3 with that of a second oral dose of @entity5 for rescue sedation during magnetic resonance imaging (MRI) studies in @entity0 . METHODS: One hundred and fifty @entity0 (age group: 1-6 months), who were not adequately sedated after initial oral dose of 50 mg  kg(-1) @entity5 , were randomly divided into three groups with the following protocol for each group. Group C: second oral dose @entity5 25 mg  kg(-1) ; Group L and Group H: intranasal @entity3 in a dosage of 1 and 2 mcg  kg(-1) , respectively. Status of sedation, induction time, time to wake up, vital signs, @entity1 saturation, and recovery characteristics were recorded. RESULTS: Successful rescue sedation in Groups C, L, and H were achieved in 40 (80%), 47 (94%), and 49 (98%) of @entity0 , respectively, on an intention to treat analysis, and the proportion of @entity0 successfully sedated in Group H was more than that of Group L (P    0.01). There were no significant differences in sedation induction time; however, the time to wake up was significantly shorter in Group L as compared to that in Group C or @entity4 (P < 0.01). No significant adverse hemodynamic or hypoxemic effects were observed in the study. CONCLUSION: Intranasal @entity3 induced satisfactory rescue sedation in 1- to 6-month-old @entity0 during MRI study, and appears to cause sedation in a dose-dependent manner.

title: Comparison of rescue techniques for failed XXXX sedation for magnetic resonance imaging scans-additional @entity5 vs intranasal @entity3 .

answer: @entity5


abstract: BACKGROUND: @entity5 , a commonly used sedative in @entity0 during noninvasive diagnostic procedures, is associated with side effects like prolonged sedation, paradoxical excitement, @entity2 , and unpleasant taste. @entity3 , a highly selective a-2 agonist, has better pharmacokinetic properties than @entity5 . We conducted this prospective, double-blind, randomized controlled trial to evaluate efficacy of intranasal @entity3 with that of a second oral dose of @entity5 for rescue sedation during magnetic resonance imaging (MRI) studies in @entity0 . METHODS: One hundred and fifty @entity0 (age group: 1-6 months), who were not adequately sedated after initial oral dose of 50 mg  kg(-1) @entity5 , were randomly divided into three groups with the following protocol for each group. Group C: second oral dose @entity5 25 mg  kg(-1) ; Group L and Group H: intranasal @entity3 in a dosage of 1 and 2 mcg  kg(-1) , respectively. Status of sedation, induction time, time to wake up, vital signs, @entity1 saturation, and recovery characteristics were recorded. RESULTS: Successful rescue sedation in Groups C, L, and H were achieved in 40 (80%), 47 (94%), and 49 (98%) of @entity0 , respectively, on an intention to treat analysis, and the proportion of @entity0 successfully sedated in Group H was more than that of Group L (P    0.01). There were no significant differences in sedation induction time; however, the time to wake up was significantly shorter in Group L as compared to that in Group C or @entity4 (P < 0.01). No significant adverse hemodynamic or hypoxemic effects were observed in the study. CONCLUSION: Intranasal @entity3 induced satisfactory rescue sedation in 1- to 6-month-old @entity0 during MRI study, and appears to cause sedation in a dose-dependent manner.

title: Comparison of rescue techniques for failed @entity5 sedation for magnetic resonance imaging scans-additional XXXX vs intranasal @entity3 .

answer: @entity5


abstract: BACKGROUND: @entity5 , a commonly used sedative in @entity0 during noninvasive diagnostic procedures, is associated with side effects like prolonged sedation, paradoxical excitement, @entity2 , and unpleasant taste. @entity3 , a highly selective a-2 agonist, has better pharmacokinetic properties than @entity5 . We conducted this prospective, double-blind, randomized controlled trial to evaluate efficacy of intranasal @entity3 with that of a second oral dose of @entity5 for rescue sedation during magnetic resonance imaging (MRI) studies in @entity0 . METHODS: One hundred and fifty @entity0 (age group: 1-6 months), who were not adequately sedated after initial oral dose of 50 mg  kg(-1) @entity5 , were randomly divided into three groups with the following protocol for each group. Group C: second oral dose @entity5 25 mg  kg(-1) ; Group L and Group H: intranasal @entity3 in a dosage of 1 and 2 mcg  kg(-1) , respectively. Status of sedation, induction time, time to wake up, vital signs, @entity1 saturation, and recovery characteristics were recorded. RESULTS: Successful rescue sedation in Groups C, L, and H were achieved in 40 (80%), 47 (94%), and 49 (98%) of @entity0 , respectively, on an intention to treat analysis, and the proportion of @entity0 successfully sedated in Group H was more than that of Group L (P    0.01). There were no significant differences in sedation induction time; however, the time to wake up was significantly shorter in Group L as compared to that in Group C or @entity4 (P < 0.01). No significant adverse hemodynamic or hypoxemic effects were observed in the study. CONCLUSION: Intranasal @entity3 induced satisfactory rescue sedation in 1- to 6-month-old @entity0 during MRI study, and appears to cause sedation in a dose-dependent manner.

title: Comparison of rescue techniques for failed @entity5 sedation for magnetic resonance imaging scans-additional @entity5 vs intranasal XXXX .

answer: @entity3


abstract: Methods. "Ameijeiras Brother's" and "Cmdt. Manuel Fajardo" Hospitals enrolled 64 @entity0 (multicentre retrospective cohort) with @entity6 and rebleeding. The @entity0 were admitted to the @entity1 Unit (SU) between January 1, 2006, and December 1, 2013. Demographic, clinical, and radiological variables were examined in logistic regression to evaluate independent factors for increasing the risk of @entity3 . Results. @entity0 with systolic blood pressure >160   mmHg (P = 0.02), serum @entity4 >7   mmol/L (P = 0.02), @entity5 location in artery communicant anterior (P = 0.03), and black/mixed race (P = 0.008) were significant related to @entity3 in univariate analysis. Risk factors (HTA, smoke, @entity2 consumption, and @entity7 ), complication, multiplex rebleeding and stage of WFNS, and Fisher's scale were not related to mortality. @entity0 with three or more complications had a higher mortality rate (P = 0.002). The results of the multivariate logistic regression analysis indicated that race (black/mixed, P = 0.00, OR 4.62, and 95% IC 1.40-16.26), systolic blood pressure (>160   mmHg, P = 0.05, OR 2.54, and 95% IC 1.01-3.13), and serum @entity4 (>7.0   mmol/L, P = 0.05, OR 1.82, and 95% IC 1.27-2.67) were independent risk factors for @entity3 . Conclusions. The black/mixed race, @entity8 , and serum @entity4 were independent predictors of mortality. Three or more complications were associated with increasing the probability to @entity3 . Further investigation is necessary to validate these findings.

title: Predictor's of Mortality in @entity0 with XXXX and Reebleding.

answer: @entity6


abstract: Methods. "Ameijeiras Brother's" and "Cmdt. Manuel Fajardo" Hospitals enrolled 64 @entity0 (multicentre retrospective cohort) with @entity6 and rebleeding. The @entity0 were admitted to the @entity1 Unit (SU) between January 1, 2006, and December 1, 2013. Demographic, clinical, and radiological variables were examined in logistic regression to evaluate independent factors for increasing the risk of @entity3 . Results. @entity0 with systolic blood pressure >160   mmHg (P = 0.02), serum @entity4 >7   mmol/L (P = 0.02), @entity5 location in artery communicant anterior (P = 0.03), and black/mixed race (P = 0.008) were significant related to @entity3 in univariate analysis. Risk factors (HTA, smoke, @entity2 consumption, and @entity7 ), complication, multiplex rebleeding and stage of WFNS, and Fisher's scale were not related to mortality. @entity0 with three or more complications had a higher mortality rate (P = 0.002). The results of the multivariate logistic regression analysis indicated that race (black/mixed, P = 0.00, OR 4.62, and 95% IC 1.40-16.26), systolic blood pressure (>160   mmHg, P = 0.05, OR 2.54, and 95% IC 1.01-3.13), and serum @entity4 (>7.0   mmol/L, P = 0.05, OR 1.82, and 95% IC 1.27-2.67) were independent risk factors for @entity3 . Conclusions. The black/mixed race, @entity8 , and serum @entity4 were independent predictors of mortality. Three or more complications were associated with increasing the probability to @entity3 . Further investigation is necessary to validate these findings.

title: Predictor's of Mortality in XXXX with @entity6 and Reebleding.

answer: @entity0


abstract: BACKGROUND: Pre-operative opioid use has been suggested to increase post-operative @entity1 and opioid consumption after total knee arthroplasty (TKA), but previous studies are either retrospective or inhomogeneous with regard to surgical procedures or control of analgesic regimes, or with few opioid-treated @entity0 , hindering firm conclusions. METHODS: In a prospective observational study, we investigated the effect of > 4 weeks pre-operative opioid use [none vs. low dose (< 30 mg @entity2 equivalents (eq.)) vs. high dose (> 30 mg @entity2 eq.] in @entity0 scheduled for primary, unilateral TKA. All @entity0 had well-defined multimodal opioid-sparring perioperative analgesic therapy, and continued any pre-operative opioid medication. The primary outcome was differences between groups in @entity1 at rest and during walk for the first 6 post-operative days. RESULTS: Among 123 @entity0 included, 115 were available for final analysis (93% follow-up rate). Post-operative @entity1 during walk was significantly increased in both opioid-treated groups vs. non-opioid-treated @entity0 (P < 0.009). Secondary analysis of combining all pre-operatively opioid-treated @entity0 vs. opioid-free @entity0 , showed significantly increased @entity1 at rest and walk and increased post-operative opioid requirement - excluding pre-operative dosage - during the first post-operative week in opioid-treated @entity0 (P = 0.001 and P = 0.007, respectively). CONCLUSION: Pre-operative opioid use increases the risk for post-operative @entity1 at rest and walk, and increased opioid consumption after TKA.

title: Chronic pre-operative opioid use and acute XXXX after fast-track total knee arthroplasty.

answer: @entity1


abstract: UNASSIGNED: @entity6 are key regulators of development, growth and reproduction in fish. In the present study we have cloned and characterized the cDNA and genomic sequences of @entity0 and @entity2 in the white seabream (Diplodus sargus). The @entity0 and @entity2 genes were encoded putatively by five and four exons, respectively. Moreover, the 5'-flanking upstream region of the @entity0 gene contained highly conserved regulatory elements including @entity3 , @entity5 , @entity4 ( @entity4 ) and the TATA box. The full-length cDNAs were 1225 and 1666 nucleotides long for @entity0 and @entity2 , respectively. Sequence analysis identified the A-E domains as well as three spliced forms involving the E domain in exons 3-5. ORF identities were higher than 83% with respect to other fish orthologs. Expression analysis demonstrated that @entity0 and its spliced forms were mostly expressed in liver, whereas the @entity2 was expressed ubiquitously not detecting significant differences among the ten tissues analyzed. Hormonal treatments using the porcine GH demonstrated a sharply increase of both @entity0 and @entity2 mRNA levels in liver and gills at 30min and 1h after injection. In the gonads, @entity0 mRNA levels increased steadily with testis and ovary maturation. In contrast, @entity2 transcript amounts were higher in immature stages (S1-S2). Hormonal treatments using GH and @entity1 demonstrated that @entity0 and @entity2 expression were upregulated in the gonads. Overall, these data demonstrate that @entity0 and @entity2 are locally expressed in several tissues and regulated by key hormones of the somatotropic and gonadotropic axes.

title: Molecular characterization and transcriptional regulation by GH and XXXX of insulin-like growth factors I and II in white seabream (Diplodus sargus).

answer: @entity1


abstract: INTRODUCTION: Pneumococcal conjugate vaccines ( @entity4 ) have indirect effects due to decreased @entity2 colonization in vaccine recipients. We sought to determine whether the introduction of PCV13 in @entity0 led to changes in the epidemiology and clinical manifestations of @entity1 ( @entity1 ) in adults. METHODS: We described demographics, comorbidities, clinical manifestations, and serotypes of @entity1 in Utah adults before (November 2009-February 2010) and after (March 2010-March 2012) the introduction of PCV13 in @entity0 . We also compare serotypes causing @entity1 in Utah adults and @entity0 . RESULTS: After the introduction of PCV13 in the childhood vaccine program, the proportion of @entity1 due to PCV13 exclusive serotypes decreased significantly in Utah adults (64-40%, p=0.009), primarily due to a decline in serotype 7F (36-15%, p=0.008). There were non-significant increases in @entity1 due to Pneumococcal polysaccharide 23 (PPV23) unique serotypes and non-vaccine serotypes, most notably serotype 22F. Changes in the proportions of vaccine and non-vaccine serotypes were similar in adults and @entity0 . @entity3 was more commonly due to non-vaccine serotypes relative to @entity3 cases (47% vs. 18%, p=0.007). When stratified by sex, decreases in PCV13 serotype @entity1 were only noted in @entity0 (76-33%, p=0.001). CONCLUSIONS: Serotype epidemiology of @entity1 in adults closely follows that of @entity0 in the PCV13 era. Continued surveillance is needed to confirm whether replacement serotypes will lead to increases in @entity5 and whether there are sex differences in the indirect effects of @entity4 vaccination in @entity0 .

title: Early XXXX serotype changes in Utah adults after the introduction of PCV13 in @entity0 .

answer: @entity2


abstract: INTRODUCTION: Pneumococcal conjugate vaccines ( @entity4 ) have indirect effects due to decreased @entity2 colonization in vaccine recipients. We sought to determine whether the introduction of PCV13 in @entity0 led to changes in the epidemiology and clinical manifestations of @entity1 ( @entity1 ) in adults. METHODS: We described demographics, comorbidities, clinical manifestations, and serotypes of @entity1 in Utah adults before (November 2009-February 2010) and after (March 2010-March 2012) the introduction of PCV13 in @entity0 . We also compare serotypes causing @entity1 in Utah adults and @entity0 . RESULTS: After the introduction of PCV13 in the childhood vaccine program, the proportion of @entity1 due to PCV13 exclusive serotypes decreased significantly in Utah adults (64-40%, p=0.009), primarily due to a decline in serotype 7F (36-15%, p=0.008). There were non-significant increases in @entity1 due to Pneumococcal polysaccharide 23 (PPV23) unique serotypes and non-vaccine serotypes, most notably serotype 22F. Changes in the proportions of vaccine and non-vaccine serotypes were similar in adults and @entity0 . @entity3 was more commonly due to non-vaccine serotypes relative to @entity3 cases (47% vs. 18%, p=0.007). When stratified by sex, decreases in PCV13 serotype @entity1 were only noted in @entity0 (76-33%, p=0.001). CONCLUSIONS: Serotype epidemiology of @entity1 in adults closely follows that of @entity0 in the PCV13 era. Continued surveillance is needed to confirm whether replacement serotypes will lead to increases in @entity5 and whether there are sex differences in the indirect effects of @entity4 vaccination in @entity0 .

title: Early @entity2 serotype changes in Utah adults after the introduction of PCV13 in XXXX .

answer: @entity0


abstract: OBJECTIVE: @entity2 ( @entity2 ) for @entity1 ( @entity1 ) can reduce relapses and delay progression; however, poor adherence and persistence with @entity2 can result in sub-optimal outcomes. The associations between @entity2 adherence and persistence and inpatient admissions and emergency room (ER) visits were investigated. METHODS: @entity0 with @entity1 who initiated a @entity2 in a US administrative claims database were followed for 1 year. Persistence to initiated @entity2 was measured as the time from @entity2 initiation to discontinuation (a gap of >60 days without drug 'on hand') or end of 1-year follow-up. Adherence to initiated @entity2 was measured during the persistent period and was operationalized as the medication possession ratio (MPR). @entity0 with an MPR <0.80 were considered non-adherent. Claims during the 1-year follow-up period were evaluated for the presence of an all-cause inpatient admission or an ER visit. Adjusted odds ratios (AORs) for inpatient admission or ER visit comparing persistent vs non-persistent and adherent vs non-adherent @entity0 were estimated using logistic regression models adjusted for @entity0 characteristics. RESULTS: The final sample included 16,218 @entity0 . During the 1-year follow-up period, 35.3% of @entity0 discontinued their initiated @entity2 and 13.9% were not adherent while on therapy. During that same period, 10.0% of @entity0 had an inpatient admission and 24.9% had an ER visit. The likelihoods of inpatient admission and ER visit were significantly decreased in persistent @entity0 (AOR [95% CI]   =   0.50 [0.45, 0.56] and 0.65 [0.60, 0.69], respectively) and in adherent @entity0 (AOR [95% CI]   =   0.83 [0.71, 0.97] and 0.86 [0.77, 0.95], respectively). CONCLUSIONS: Persistence and adherence with initiated @entity2 are associated with decreased likelihoods of inpatient admission or ER visit, which may translate to improved clinical outcomes.

title: The impact of persistence with therapy on inpatient admissions and emergency room visits in the US among @entity0 with XXXX .

answer: @entity1


abstract: OBJECTIVE: @entity2 ( @entity2 ) for @entity1 ( @entity1 ) can reduce relapses and delay progression; however, poor adherence and persistence with @entity2 can result in sub-optimal outcomes. The associations between @entity2 adherence and persistence and inpatient admissions and emergency room (ER) visits were investigated. METHODS: @entity0 with @entity1 who initiated a @entity2 in a US administrative claims database were followed for 1 year. Persistence to initiated @entity2 was measured as the time from @entity2 initiation to discontinuation (a gap of >60 days without drug 'on hand') or end of 1-year follow-up. Adherence to initiated @entity2 was measured during the persistent period and was operationalized as the medication possession ratio (MPR). @entity0 with an MPR <0.80 were considered non-adherent. Claims during the 1-year follow-up period were evaluated for the presence of an all-cause inpatient admission or an ER visit. Adjusted odds ratios (AORs) for inpatient admission or ER visit comparing persistent vs non-persistent and adherent vs non-adherent @entity0 were estimated using logistic regression models adjusted for @entity0 characteristics. RESULTS: The final sample included 16,218 @entity0 . During the 1-year follow-up period, 35.3% of @entity0 discontinued their initiated @entity2 and 13.9% were not adherent while on therapy. During that same period, 10.0% of @entity0 had an inpatient admission and 24.9% had an ER visit. The likelihoods of inpatient admission and ER visit were significantly decreased in persistent @entity0 (AOR [95% CI]   =   0.50 [0.45, 0.56] and 0.65 [0.60, 0.69], respectively) and in adherent @entity0 (AOR [95% CI]   =   0.83 [0.71, 0.97] and 0.86 [0.77, 0.95], respectively). CONCLUSIONS: Persistence and adherence with initiated @entity2 are associated with decreased likelihoods of inpatient admission or ER visit, which may translate to improved clinical outcomes.

title: The impact of persistence with therapy on inpatient admissions and emergency room visits in the US among XXXX with @entity1 .

answer: @entity0


abstract: PURPOSE: @entity1 ( @entity1 ) management is challenging. In recent years, efforts were undertaken to achieve better @entity1 management, e.g. clinical research, new treatment modalities, development of guidelines, education and focus on implementation. The aim of the present study was to compare the prevalence and characteristics of @entity2 and @entity2 ( @entity2 ) between cross-sectional studies conducted in 2008 and 2014. It was hypothesized that an improvement in @entity2 control would be observed the years in between. METHODS: Two cross-sectional studies were conducted where @entity1 @entity0 answered questions from Brief Pain Inventory and the Alberta Breakthrough Pain Assessment Tool for @entity1 @entity0 . Physicians reported socio-demographic and medical data. Regression models were applied for analysis. RESULTS: In total, 168 inpatients, 92 in 2008 and 76 in 2014, and 675 outpatients, 301 in 2008 and 374 in 2014, were included. The @entity0 characteristics of the samples were comparable. Prevalence of @entity1 among inpatients was 55  % in 2008 and 53  % in 2014, and among outpatients, 39 and 35  %, respectively. Inpatients reported average @entity2 intensity (0-10 numerical rating scale, NRS) of 3.60 (standard deviation, SD 1.84) (2008) and 4.08 (SD 2.11) (2014); prevalence of @entity2 was 52  % (2008) and 41  % (2014). For outpatients, average @entity2 intensity was 3.60 (SD 2.04) (2008) and 3.86 (SD 2.20) (2014); prevalence of @entity2 was 43  % (2008) and 37  % (2014). None of the differences were statistically significant. CONCLUSION: Unexpectedly, no improvement in @entity2 control was observed. Efforts are still needed to improve @entity1 management.

title: Is it possible to detect an improvement in XXXX management? A comparison of two Norwegian cross-sectional studies conducted 5  years apart.

answer: @entity1


abstract: BACKGROUND: More and more @entity0 are being treated with direct oral anticoagulants (DOAC). Under treatment with DOACs @entity2 appears to occur more frequently, particularly in the lower gastrointestinal tract, compared to treatment with @entity6 antagonists (e.g. @entity5 ). OBJECTIVE: A possible approach should now be elaborated in a joint effort by gastroenterologists and cardiologists. MATERIAL AND METHODS: A selective literatue search was carried out and own experiences were also included. RESULTS: The decision to perform procoagulant therapy by slowly injecting 30-50  IU prothrombin complex concentrate ( @entity8 ) per kg body weight intravenously depends on various factors and should be assessed critically. Specific antidotes are awaiting approval. After a @entity3 episode potentially controllable and reversible triggers must be excluded (e.g. drug interactions and @entity1 ). The risk of recurrent @entity3 and the risk of @entity4 events have to be weighed against each other before deciding to readminister an anticoagulant and its form. Dose reduction and changing to @entity7 (in reduced dosage) are options for risk reduction and @entity6 antagonists can also be considered. DISCUSSION: It is still unclear what role specific antidotes will play.

title: [Direct oral anticoagulation and XXXX : Interventional therapy management].

answer: @entity2


abstract: INTRODUCTION AND AIMS: Despite advances towards integration of care for @entity0 with co-occurring @entity3 ( @entity3 ) and @entity4 ( @entity4 ), low abstinence rates following @entity3 / @entity4 treatment remain the norm. The utility of investigating distinct substance use trajectories is a critical innovation in the detection and refining of effective interventions for this clinical population. DESIGN AND METHODS: The present study reanalysed data from the largest randomised clinical trial to date for co-occurring @entity3 and @entity4 in @entity0 (National Drug Abuse Treatment Clinical Trials Network; @entity0 and @entity1 Study). Randomised @entity0 (n   =   353) received one of two interventions in addition to treatment as usual for @entity3 : (i) @entity1 -informed integrative treatment for @entity4 / @entity3 ; or (ii) an active control psychoeducation course on @entity0 's health. The present study utilised latent growth mixture models (LGMM) with multiple groups to estimate @entity0 's substance use patterns during the 12-month follow-up period. RESULTS: Findings provided support for three different trajectories of substance use in the post-treatment year: (i) consistently low likelihood and use frequency; (ii) consistently high likelihood and use frequency; and (iii) high likelihood and moderate use frequency. Covariate analyses revealed improvement in @entity4 severity was associated with membership in a specific substance use trajectory, although receiving @entity1 -informed treatment was not. Additionally, @entity3 severity, age and after-care efforts were shown to be related to trajectory membership. DISCUSSION AND CONCLUSIONS: Findings highlight the necessity of accounting for heterogeneity in post-treatment substance use, relevance of @entity1 -informed care in @entity3 recovery and benefits of incorporating methodologies like LGMM when evaluating @entity3 treatment outcomes. [L  pez-Castro T, Hu M-C, Papini S, Ruglass LM, Hien DA. Pathways to change: Use trajectories following @entity1 -informed treatment of @entity0 with co-occurring @entity4 and substance use disorders. Drug @entity2 Rev 2015].

title: Pathways to change: Use trajectories following XXXX -informed treatment of @entity0 with co-occurring @entity4 and substance use disorders.

answer: @entity1


abstract: INTRODUCTION AND AIMS: Despite advances towards integration of care for @entity0 with co-occurring @entity3 ( @entity3 ) and @entity4 ( @entity4 ), low abstinence rates following @entity3 / @entity4 treatment remain the norm. The utility of investigating distinct substance use trajectories is a critical innovation in the detection and refining of effective interventions for this clinical population. DESIGN AND METHODS: The present study reanalysed data from the largest randomised clinical trial to date for co-occurring @entity3 and @entity4 in @entity0 (National Drug Abuse Treatment Clinical Trials Network; @entity0 and @entity1 Study). Randomised @entity0 (n   =   353) received one of two interventions in addition to treatment as usual for @entity3 : (i) @entity1 -informed integrative treatment for @entity4 / @entity3 ; or (ii) an active control psychoeducation course on @entity0 's health. The present study utilised latent growth mixture models (LGMM) with multiple groups to estimate @entity0 's substance use patterns during the 12-month follow-up period. RESULTS: Findings provided support for three different trajectories of substance use in the post-treatment year: (i) consistently low likelihood and use frequency; (ii) consistently high likelihood and use frequency; and (iii) high likelihood and moderate use frequency. Covariate analyses revealed improvement in @entity4 severity was associated with membership in a specific substance use trajectory, although receiving @entity1 -informed treatment was not. Additionally, @entity3 severity, age and after-care efforts were shown to be related to trajectory membership. DISCUSSION AND CONCLUSIONS: Findings highlight the necessity of accounting for heterogeneity in post-treatment substance use, relevance of @entity1 -informed care in @entity3 recovery and benefits of incorporating methodologies like LGMM when evaluating @entity3 treatment outcomes. [L  pez-Castro T, Hu M-C, Papini S, Ruglass LM, Hien DA. Pathways to change: Use trajectories following @entity1 -informed treatment of @entity0 with co-occurring @entity4 and substance use disorders. Drug @entity2 Rev 2015].

title: Pathways to change: Use trajectories following @entity1 -informed treatment of @entity0 with co-occurring XXXX and substance use disorders.

answer: @entity4


abstract: INTRODUCTION AND AIMS: Despite advances towards integration of care for @entity0 with co-occurring @entity3 ( @entity3 ) and @entity4 ( @entity4 ), low abstinence rates following @entity3 / @entity4 treatment remain the norm. The utility of investigating distinct substance use trajectories is a critical innovation in the detection and refining of effective interventions for this clinical population. DESIGN AND METHODS: The present study reanalysed data from the largest randomised clinical trial to date for co-occurring @entity3 and @entity4 in @entity0 (National Drug Abuse Treatment Clinical Trials Network; @entity0 and @entity1 Study). Randomised @entity0 (n   =   353) received one of two interventions in addition to treatment as usual for @entity3 : (i) @entity1 -informed integrative treatment for @entity4 / @entity3 ; or (ii) an active control psychoeducation course on @entity0 's health. The present study utilised latent growth mixture models (LGMM) with multiple groups to estimate @entity0 's substance use patterns during the 12-month follow-up period. RESULTS: Findings provided support for three different trajectories of substance use in the post-treatment year: (i) consistently low likelihood and use frequency; (ii) consistently high likelihood and use frequency; and (iii) high likelihood and moderate use frequency. Covariate analyses revealed improvement in @entity4 severity was associated with membership in a specific substance use trajectory, although receiving @entity1 -informed treatment was not. Additionally, @entity3 severity, age and after-care efforts were shown to be related to trajectory membership. DISCUSSION AND CONCLUSIONS: Findings highlight the necessity of accounting for heterogeneity in post-treatment substance use, relevance of @entity1 -informed care in @entity3 recovery and benefits of incorporating methodologies like LGMM when evaluating @entity3 treatment outcomes. [L  pez-Castro T, Hu M-C, Papini S, Ruglass LM, Hien DA. Pathways to change: Use trajectories following @entity1 -informed treatment of @entity0 with co-occurring @entity4 and substance use disorders. Drug @entity2 Rev 2015].

title: Pathways to change: Use trajectories following @entity1 -informed treatment of XXXX with co-occurring @entity4 and substance use disorders.

answer: @entity0


abstract: UNASSIGNED: Incomplete removal of pharmaceuticals during wastewater treatment can result in their discharge into the aquatic environment. The discharge of pharmaceuticals in wastewater treatment plant (WWTP) effluents into rivers, lakes and the oceans has led to detectable concentrations of pharmaceuticals in the aquatic environment in many countries. However, to date studies of WWTP discharges into the aquatic environment have largely been confined to areas of relatively high population density, industrial activity or systems impacted on by such areas. In this work, two sites in the far north of Scotland were used to assess whether, and which, pharmaceuticals were being introduced into natural waters in a rural environment with low population density. Samples from two WWTPs (with differing modes of operation), and one receiving water, the River Thurso, were analysed for the presence of 12 pharmaceuticals ( @entity7 , @entity11 , @entity6 , @entity8 , @entity9 , @entity5 , @entity4 , @entity2 , @entity3 , @entity1 and @entity10 ). Ten of the 12 pharmaceuticals investigated were detected in at least one of the 40 WWTP effluent samples. Maximum concentrations ranged from 7  ng  L(-1) ( @entity2 ) to 22.8   g  L(-1) ( @entity5 ) with @entity7 and @entity9 being present in all of samples analysed at concentrations between 24.2 and 927  ng  L(-1) and 11.5 and 22.8   g  L(-1), respectively. Additionally, the presence of four pharmaceuticals at ng L(-1) levels in the River Thurso, into which one of the WWTPs discharges, shows that such discharges result in measurable levels of pharmaceuticals in the environment. This provides direct evidence that, even in rural areas with low population densities, effluents from WWTPs can produce quantifiable levels of @entity0 pharmaceutical in the natural aquatic environment. These observations indicate that @entity0 pharmaceuticals may be considered as contaminants, with potential to influence water quality, management and conservation not only in urban and industrial regions but also those more rural in nature.

title: Introduction of XXXX pharmaceuticals from wastewater treatment plants into the aquatic environment: a rural perspective.

answer: @entity0


abstract: BACKGROUND: Locally advanced @entity1 is generally incurable and has a short survival rate. This study aimed to evaluate symptom relief, disease response, and acute @entity2 after palliative hypo-fractionated radiotherapy and long-term survival in affected @entity0 . MATERIALS AND METHODS: Between January 2011 to December 2011, 80 @entity0 who were histopathologically diagnosed as having stage III or stage IV @entity1 and @entity4 based on Eastern Cooperative Oncology Group (ECOG) performance status 1-3, were offered palliative radiotherapy (20 Gy/5Fr/5 Days). Later these @entity0 were evaluated on 30th day after completion of treatment for disease response based on World Health Organisation (WHO) criteria and palliation of symptoms using symptomatic response grading and acute @entity2 by the Radiation Therapy Oncology Group (RTOG). Many @entity0 were given post @entity5 ( @entity5 ) palliative chemotherapy for appropriate palliative care and a few @entity0 were selected for further curative @entity5 . The overall survival was also evaluated among this group of @entity0 with last follow up date of 1st May, 2014. RESULTS: The most common presenting complaint was @entity3 followed by @entity6 . Most @entity0 (60-70%) had appreciable relief in their presenting symptoms. A good response was observed in the majority following palliative @entity5 ; a few @entity0 had progressive disease and some had stable and regressed disease. None of the @entity0 experienced radiation @entity2 that required hospital admission. Almost all showed grade one and two acute skin and mucosal @entity2 one month after completion of treatment. The mean survival days for @entity0 given only hypofractionated palliative @entity5 was 307 days, those with post palliative @entity5 and palliative chemotherapy was 390 days and @entity0 who went on to receive further palliative @entity5 and curative @entity5 dose had significantly overall survival of 582 days. CONCLUSIONS: @entity1 should be identified for suitable palliative hypofractionated radiotherapy to achieve acceptable symptom relief in a great proportion of @entity0 and should be followed by palliative chemotherapy or curative @entity5 in suitable cases for long-term symptom-free survival.

title: End stage palliative care of XXXX : a case study.

answer: @entity1


abstract: BACKGROUND: @entity3 is the most common @entity2 in the Iranian population. The aim of this study was to determine the effect of clinicopathological factors on prognosis by meta-analysis. MATERIALS AND METHODS: A literature search was conducted using MEDLINE, EMBASE and Cochrane library and extensive literature search using the Persian databases until February 2011. Prospective follow up studies with multivariate analysis of overall survival of the @entity0 with @entity3 were included in this review. The data were analyzed by CMA.2. Publication bias are checked by funnel plot and data are shown as Forest plots. RESULTS: From a total of 63 articles, 14 retrospective studies which examined 5 prognostic factors and involving 10,500 @entity0 were included. @entity2 size (>35mm) was the main significant factor predicting an unfavorable prognosis for the @entity0 with @entity3 (RR=1.829 , p<0.001) followed by presence of distant @entity1 (RR=1.607 , p<0.001), poor differentiation (RR=1.408 , p<0.001) and male sex (RR=1.194, p<0.001). Lymph node @entity1 (RR=1.058, p=0.698) and moderate differentiation (RR=0.836, p=0.043) were not statistically significant as prognostic factors. CONCLUSIONS: This meta-analysis suggests that @entity2 size>35mm, poor differentiation, presence of distant @entity1 and male gender are strongly associated with a poor prognosis in Iranian @entity0 with @entity3 .

title: Clinicopathological Factors and XXXX Prognosis in the Iranian Population: a Meta-analysis.

answer: @entity3


abstract: BACKGROUND: The clinical implementation of genomic profiling for @entity1 with high-throughput, multiplex tests is warranted to allow prioritization of appropriate therapies for individual @entity0 . We have now applied such testing to detect actionable mutations that may inform treatment recommendations in @entity1 . @entity0 AND METHODS: We prospectively applied amplicon sequencing panels that cover both mutational hotspots in 22 genes related to lung and colon tumorigenesis as well as 72 major variants of ALK, @entity12 , @entity13 , and @entity10 fusion transcripts. We then determined the proportion of @entity0 who received genotype-directed therapy and their overall survival (OS). RESULTS: Tumor specimens from 110 @entity0 with @entity1 recruited between July 2013 and March 2015 were analyzed. The most common genetic alterations were @entity6 mutations in 42 @entity0 , followed by @entity5 mutations in 25, @entity11 mutations in 12, and @entity9 mutations in 10. Potentially actionable mutations were identified in 44 @entity0 including 50% of those with @entity4 and 14% of those with @entity7 . The OS of @entity0 with advanced or recurrent @entity2 who had an actionable mutation and received targeted therapy (median OS not achieved) was significantly longer than that of those with no mutation (18.1 months, P = 0.041) or of those with a mutation not so treated (6.1 months, P = 0.0027). CONCLUSIONS: Multiplex genomic testing was performed on @entity3 -fixed, @entity8 -embedded @entity2 specimens with a success rate of >= 95%. Such testing can assist physicians in matching @entity0 with approved or experimental targeted treatments. CLINICAL TRIAL REGISTRATION: The University Medical Hospital Information Network (UMIN) Clinical Trials Registry under the identifier UMIN000014782.

title: Clinical application of amplicon-based next-generation sequencing to therapeutic decision making in XXXX .

answer: @entity1


abstract: Side population (SP) cells have stem cell-like properties with a capacity for self-renewal and are resistant to chemotherapy and radiotherapy. Therefore the presence of SP cells in @entity1 @entity0 probably has prognostic value. OBJECTIVE: To investigate the characteristics of SP cells and identify the relationship between the SP cells levels and clinico-pathological parameters of the @entity0 and disease-free survival (DFS) in @entity0 @entity1 . MATERIALS AND METHODS: A total of 122 eligible @entity0 @entity1 were consecutively recruited from January 1, 2006 to December 31, 2007 at Yunnan Tumor Hospital. All eligible subjects received conventional treatment and were followed up for seven years. Predictors of recurrence and/or @entity2 and DFS were analyzed using Cox regression analysis. @entity1 @entity0 cells were also obtained from fresh @entity1 @entity0 tissue and cultured by the nucleic acid dye @entity4 with Verapami. Flow cytometry (FCM) was employed to isolate the cells of SP and non-SP types. RESULTS: In this study, SP cells were identified using flow cytometric analysis with @entity4 dye efflux. Adjusted for age, @entity3 size, lymph nodal status, histological grade, the Cox model showed a higher risk of recurrence and/or @entity2 positively associated with the SP cell level (1.75, 1.02-2.98), as well as with axillary lymph node @entity2 (2.99, 1.76-5.09), pathology invasiveness type (1.7, 1.14-2.55), and @entity3 volume doubling time (TVDT) (1.54, 1.01-2.36). CONCLUSIONS: The SP cell level is independently associated with @entity3 progression and clinical outcome after controlling for other pathological factors. The axillary lymph node status, TVDT and the status of non-invasive or invasive @entity3 independently predict the prognosis of @entity0 .

title: Side Population Cell Level in XXXX Breast Cancer and Factors Related to Disease-free Survival.

answer: @entity1


abstract: AIM: The management of @entity1 threatening or affecting the prostatic plane is still under debate. The role of the preoperative chemo-radiotherapy and the extent of prostatectomy seem to be key-points in the treatment of these @entity1 . The aim of the present study was to evaluate the pathological circumferential margin status and the local recurrence rate following different therapeutic options. METHOD: A multicentre, retrospective study was conducted of @entity0 with @entity1 threatening or affecting the prostatic plane judged by magnetic resonance imaging (MRI). The use of preoperative chemoradiotherapy and the type of urologic resection were correlated with the status of the pathological circumferential resection margin (CRM) and local recurrence. RESULTS: A consecutive series of 126 males with @entity1 threatening (44) or affecting (82) the prostatic plane on preoperative staging and operated with local curative intent between 1998-2010 was analysed. In @entity0 who did not have chemoradiotherapy but a threatened anterior margin the CRM positive rate was 25.0%. In @entity0 having no preoperative chemoradiotherapy who had an affected margin, the rate was 41.7%. When preoperative radiotherapy was given, the respective CRM infiltration rates were 7.1% and 20.7%. In @entity0 having preoperative chemoradiotherapy followed by prostatic resection the rate of CRM positivity was 2.4%. Partial prostatectomy after preoperative chemo-radiotherapy resulted in a free anterior circumferential resection margin in all cases, but intraoperative @entity2 occurred in 36.4% of the @entity0 who underwent partial prostatectomy, resulting in a postoperative urinary fistula in 18.2% of @entity0 . CONCLUSION: preoperative chemoradiation is mandatory in male @entity0 with a threatened or affected anterior circumferential margin on preoperative MRI. In @entity0 with preoperative @entity3 , prostatic resection is necessary. In this group of @entity0 partial prostatectomy seems to be oncologically safe. This article is protected by copyright. All rights reserved.

title: XXXX threatening or affecting the prostatic plane: is partial prostatectomy oncologically adequate? Results of a multicentre retrospective study.

answer: @entity1


abstract: UNASSIGNED: This paper aimed to study the effect of Ramadan fasting on biochemical and clinical parameters and compliance for dialysis. A prospective multicenter observational cross-sectional study comparing fasting with a non-fasting stable adult hemodialysis @entity0 for demographic and biochemical parameters, compliance with dialysis, inter-dialytic @entity4 , pre- and post-blood pressure, and frequency of intradialytic @entity2 episodes was carried out. Six hundred thirty-five @entity0 , of whom 64.1% fasted, were studied. The fasters were younger (53.3        16.2 vs. 58.4        16.1 years; P   =   0.001) but had similar duration on dialysis (P   =   0.35). More fasters worked (22.0% vs. 14.6%; P   =   0.001) and missed dialysis sessions during Ramadan. No differences were noted between groups in sex, @entity1 status, or dialysis shift or day. There were no differences in the pre- and post-dialysis blood pressure; serum @entity3 , albumin or @entity4 ; @entity1 status; sex; and dialysis shift time or days. However, serum phosphorous was significantly higher in the fasting group (2.78        1.8 vs. 2.45        1.6   mmol/L; P   =   0.045). There were no intragroup differences in any of the parameters studied when comparing the findings during Ramadan with those in the month before Ramadan. Fasters were significantly younger and more likely to be working, to miss dialysis sessions, and to have higher serum phosphorous levels. No other differences were observed.

title: Changes in biochemical, hemodynamic, and dialysis adherence parameters in hemodialysis XXXX during Ramadan.

answer: @entity0


abstract: BACKGROUND: Treat-to-target (T2T) is a widely accepted management strategy for @entity1 ( @entity1 ) with a key decision point at 3   months after treatment initiation. At this time point, it remains unclear which @entity0 will benefit from treatment adaptation or from continuation of existing treatment. METHODS: We performed a pooled analysis of @entity0 -level clinical trial data of @entity0 with @entity1 . We used a diagnostic testing methodology and a probabilistic approach employing logistic regression to investigate which levels of response at 3 months can inform treatment decisions in regard to achieving the target at 6   months. RESULTS: To be at least 80% sensitive for achieving the low disease activity (LDA) target at 6   months, a change at 3   months in Simplified Disease Activity Index/Clinical Disease Activity Index (SDAI or CDAI) of 58% needs to be observed at 3   months. Higher changes are needed to sensitively predict @entity2 ( @entity2 ). Not reaching the (minor) SDAI 50% response level is afflicted with very low negative likelihood ratios (LRs) (0.28 for LDA and 0.07 for @entity2 at 6   months). Experiencing (major) SDAI 85% response has substantial positive LRs of 9.2 for reaching LDA and 6.2 for reaching @entity2 at 6   months. In logistic regression, the change at 3   months is significantly associated with reaching of the target at 6   months. CONCLUSIONS: The 3-month time point is a critical decision point. Not achieving minor responses at 3   months makes reaching of the treatment target at 6   months highly unlikely, while reaching major responses is highly predictive of reaching the treatment target.

title: Optimisation of a treat-to-target approach in XXXX : strategies for the 3-month time point.

answer: @entity1


abstract: Twenty normal piglets were radiographed and necropsied. Bronchography was performed in seven of the animals. In dorso-ventral radiographs the borders of the heart are clearly outlined by the adjacent lung lobes. In lateral films the lung fields may be divided into a cranial portion extending from the thoracic inlet to the third pair of ribs and a triangular shaped caudal portion with its base the caudal border of the heart and its apex the phrenico-vertebral angle. Nine field cases of @entity0 and nine experimentally induced cases were examined radiologically. They were then necropsied and the radiological and pathological findings related to each other. @entity1 was identified radiologically as areas of unaerated lung which caused loss of the borders of the heart and diaphragm (silhouette sign) and enhancement of the image of the segmental and smaller bronchi (air bronchogram sign). The silhouette sign correctly predicted @entity1 of lobes in 77 per cent of field cases and in 54 per cent of lobes of experimental cases. The air bronchogram sign correctly predicted consolidation in 73 per cent of lobes of field cases and 76 per cent of lobes of experimental cases. A radiological examination has limitations for determining whether @entity2 are free of @entity0 because foci of consolidation less than 2 cm3 may not be detected.

title: A radiological investigation of XXXX in the @entity2 .

answer: @entity0


abstract: Twenty normal piglets were radiographed and necropsied. Bronchography was performed in seven of the animals. In dorso-ventral radiographs the borders of the heart are clearly outlined by the adjacent lung lobes. In lateral films the lung fields may be divided into a cranial portion extending from the thoracic inlet to the third pair of ribs and a triangular shaped caudal portion with its base the caudal border of the heart and its apex the phrenico-vertebral angle. Nine field cases of @entity0 and nine experimentally induced cases were examined radiologically. They were then necropsied and the radiological and pathological findings related to each other. @entity1 was identified radiologically as areas of unaerated lung which caused loss of the borders of the heart and diaphragm (silhouette sign) and enhancement of the image of the segmental and smaller bronchi (air bronchogram sign). The silhouette sign correctly predicted @entity1 of lobes in 77 per cent of field cases and in 54 per cent of lobes of experimental cases. The air bronchogram sign correctly predicted consolidation in 73 per cent of lobes of field cases and 76 per cent of lobes of experimental cases. A radiological examination has limitations for determining whether @entity2 are free of @entity0 because foci of consolidation less than 2 cm3 may not be detected.

title: A radiological investigation of @entity0 in the XXXX .

answer: @entity2


abstract: A retinal prosthesis is being developed for the restoration of vision in @entity0 with @entity6 ( @entity6 ) and @entity3 ( @entity3 ). Determining optimal electrical stimulation parameters for the prosthesis is one of the most important elements for the development of a viable retinal prosthesis. Here, we investigated the effects of different charge-balanced biphasic pulses with regard to their effectiveness in evoking @entity5 cell (RGC) responses. @entity4 ( @entity7 ) @entity1 were used (n=17). From the ex-vivo retinal preparation, retinal patches were placed ganglion cell layer down onto an 8*8 multielectrode array (MEA) and RGC responses were recorded while applying electrical stimuli. For asymmetric pulses, 1st phase of the pulse is the same with symmetric pulse but the amplitude of 2nd phase of the pulse is less than 10   A and charge @entity2 is satisfied by lengthening the duration of the pulse. For intensities (or duration) modulation, duration (or amplitude) of the pulse was fixed to 500   s (30   A), changing the intensities (or duration) from 2 to 60   A (60 to 1000   s). RGCs were classified as response-positive when PSTH showed multiple (3~4) peaks within 400 ms post stimulus and the number of spikes was at least 30% more than that for the immediate pre-stimulus 400 ms period. RGC responses were well modulated both with anodic and cathodic phase-1st biphasic pulses. Cathodic phase-1st pulses produced significantly better modulation of RGC activity than anodic phase-1st pulses regardless of symmetry of the pulse.

title: Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration ( XXXX ) @entity1 .

answer: @entity7


abstract: A retinal prosthesis is being developed for the restoration of vision in @entity0 with @entity6 ( @entity6 ) and @entity3 ( @entity3 ). Determining optimal electrical stimulation parameters for the prosthesis is one of the most important elements for the development of a viable retinal prosthesis. Here, we investigated the effects of different charge-balanced biphasic pulses with regard to their effectiveness in evoking @entity5 cell (RGC) responses. @entity4 ( @entity7 ) @entity1 were used (n=17). From the ex-vivo retinal preparation, retinal patches were placed ganglion cell layer down onto an 8*8 multielectrode array (MEA) and RGC responses were recorded while applying electrical stimuli. For asymmetric pulses, 1st phase of the pulse is the same with symmetric pulse but the amplitude of 2nd phase of the pulse is less than 10   A and charge @entity2 is satisfied by lengthening the duration of the pulse. For intensities (or duration) modulation, duration (or amplitude) of the pulse was fixed to 500   s (30   A), changing the intensities (or duration) from 2 to 60   A (60 to 1000   s). RGCs were classified as response-positive when PSTH showed multiple (3~4) peaks within 400 ms post stimulus and the number of spikes was at least 30% more than that for the immediate pre-stimulus 400 ms period. RGC responses were well modulated both with anodic and cathodic phase-1st biphasic pulses. Cathodic phase-1st pulses produced significantly better modulation of RGC activity than anodic phase-1st pulses regardless of symmetry of the pulse.

title: Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration ( @entity7 ) XXXX .

answer: @entity1


abstract: BACKGROUND: Insulin-like growth factor I ( @entity1 ) measurements are used in veterinary medicine for diagnosing growth hormone disorders. @entity1 assays are subject to interference by IGF-binding proteins (IGFBP) which may not be efficiently removed by standard extraction methods. Adding excess @entity3 during analysis may improve accuracy. OBJECTIVES: The purpose of the study was to validate a commercial @entity0 @entity1 ELISA which uses excess @entity3 for feline samples and to evaluate biologic variation. METHODS: Precision was determined by calculating the coefficient of variation (CV). Accuracy was determined by recovery after removal of IGFBP, addition of @entity1 , and linear dilution after the addition of IGFBP. Biologic variation was determined by repeated sampling in 7 @entity2 . RESULTS: There was interference by IGFBP in the high measuring range, resulting in falsely low @entity1 concentrations. This was overcome by the addition of high concentrations of @entity3 . Untreated serum had a measured/expected ratio of 98-115% compared to serum where IGFBP had been removed. Recovery after the addition of @entity1 was 83-112%. Inter- and intra-assay CVs ranged from 2.4% to 5.0% which is within the minimum acceptance criteria based on biologic variation. The reference interval of @entity1 was wide (90-1207  ng/mL) and there was a significant association between body weight and ln  @entity1 (P  <  .000001). CONCLUSIONS: This @entity0 ELISA is suitable for feline samples, but interfering IGFBP can cause falsely low concentrations. It is recommended to dilute samples such that @entity1 is <  28  ng/mL on the standard curve to grant for sufficient @entity3 for binding of interferent IGFBP.

title: Insulin-like growth factor I in XXXX : validation of an enzyme-linked immunosorbent assay and determination of biologic variation.

answer: @entity2


abstract: BACKGROUND: Central @entity1 has been recognized as a main risk factor for cardiovascular (CV) events. Three popular central @entity1 indices are waist circumference, waist-to-hip ratio (WHR), and waist-to-height ratio; abdominal volume index and conicity index are 2 recent novel @entity1 indices. The main aim of this study is to determine the performance of these indices to best predict 10-year CV events. HYPOTHESIS: Some @entity1 indices can be used to predict cardiovascular risk. METHODS: In total, 3199 subjects (age range, 40-79 years) were enrolled in this cross-sectional study. The American College of Cardiology/American Heart Association and Framingham risk score tools were used to estimate the 10-year CV events. Receiver operating characteristic curve analysis was used to determine the optimal discriminator(s) among the central @entity1 measures in the estimation of a 10-year risk of CV events >= 7.5%, >= 10%, and >= 20% separately. RESULTS: Among the 5 central @entity1 indices, conicity index showed the most discriminatory power in estimation of a 10-year CV risk. In @entity0 , based on the American College of Cardiology/American Heart Association tool, the areas under the curve (AUCs) were from 0.671 to 0.682 based on the 3 above thresholds, whereas with the Framingham tool, AUCs were from 0.651 to 0.659. In @entity0 , all AUCs were >0.7. Our results also showed WHR to be an almost comparable discriminator of CV disease risk in the Iranian study population. CONCLUSION: Conicity index and WHR had a more discriminatory accuracy for 10-year CV events compared with the other @entity1 indices.

title: Conicity Index and Waist-to-Hip Ratio Are Superior Obesity Indices in Predicting 10-Year Cardiovascular Risk Among XXXX and @entity0 .

answer: @entity0


abstract: BACKGROUND: Central @entity1 has been recognized as a main risk factor for cardiovascular (CV) events. Three popular central @entity1 indices are waist circumference, waist-to-hip ratio (WHR), and waist-to-height ratio; abdominal volume index and conicity index are 2 recent novel @entity1 indices. The main aim of this study is to determine the performance of these indices to best predict 10-year CV events. HYPOTHESIS: Some @entity1 indices can be used to predict cardiovascular risk. METHODS: In total, 3199 subjects (age range, 40-79 years) were enrolled in this cross-sectional study. The American College of Cardiology/American Heart Association and Framingham risk score tools were used to estimate the 10-year CV events. Receiver operating characteristic curve analysis was used to determine the optimal discriminator(s) among the central @entity1 measures in the estimation of a 10-year risk of CV events >= 7.5%, >= 10%, and >= 20% separately. RESULTS: Among the 5 central @entity1 indices, conicity index showed the most discriminatory power in estimation of a 10-year CV risk. In @entity0 , based on the American College of Cardiology/American Heart Association tool, the areas under the curve (AUCs) were from 0.671 to 0.682 based on the 3 above thresholds, whereas with the Framingham tool, AUCs were from 0.651 to 0.659. In @entity0 , all AUCs were >0.7. Our results also showed WHR to be an almost comparable discriminator of CV disease risk in the Iranian study population. CONCLUSION: Conicity index and WHR had a more discriminatory accuracy for 10-year CV events compared with the other @entity1 indices.

title: Conicity Index and Waist-to-Hip Ratio Are Superior Obesity Indices in Predicting 10-Year Cardiovascular Risk Among @entity0 and XXXX .

answer: @entity0


abstract: OBJECTIVE: To present an objective method to evaluate gait improvements after a tap test in idiopathic normal pressure @entity1 (INPH). DESIGN: Retrospective analysis of gait data. SETTING: Public tertiary care center, day hospital. The gait analysis was performed before and 2 to 4 hours after the tap test. @entity0 : @entity0 included @entity0 with INPH (n=60) and age- and sex-matched controls (n=50; used to obtain reference intervals). From an initial referred sample of 79 @entity0 (N=79), we excluded those unable to walk without walking aids (n=9) and those with incomplete (pre-/posttap test) gait data (n=10). Thirteen out of 60 @entity0 were shunted and then reappraised after 6 months. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Mahalanobis distance from controls, before and after the tap test. Eleven gait parameters were combined in a single quantitative score. Walking velocity was also evaluated because it is frequently used in tap test assessment. RESULTS: @entity0 were classified into 2 groups: tap test responders (n=22, 9 of them were shunted) and not suitable for shunt (n=38, 4 of them were shunted). In the tap test responders group, 9 out of 9 @entity0 improved after shunt. In the not suitable for shunt group, 3 out of 4 @entity0 did not improve. Gait velocity increased after the tap test in 53% of responders and in 37% of @entity0 not suitable for shunt. CONCLUSIONS: The new method is applicable to clinical practice and allows for selecting tap test responders in an objective way, quantifying the improvements. Our results suggest that gait velocity alone is not sufficient to reliably assess tap test effects.

title: Instrumented Gait Analysis for an Objective Pre-/Postassessment of Tap Test in Normal Pressure XXXX .

answer: @entity1


abstract: BACKGROUND: Autologous fat grafting (AFG) has been widely used to treat @entity3 ( @entity3 ). However, objective and quantitative analyses in @entity0 with @entity3 are complicated because of multidimensional @entity1 and fat absorption. This study aimed to introduce a new method to predict @entity2 of soft tissues and objectively evaluate the survival of grafted fat with 3-dimensional (3D) and mirror-image analysis (MIA). METHODS: Thirty-one @entity0 with @entity3 were classified into 2 groups based on the location of the facial midsagittal plane (FMP), which was established through our proposed method using nasion (point a), anterior nasal spine (point b), and pogonion (point c). The included cases with centered FMP were treated using serial AFG and followed up for 12 to 15 months. Images were obtained preoperatively (pre-OP) and postoperatively at 2 time points (3 months and 12 months). Three-dimensional computed tomography (CT) was performed before the first surgery to locate the FMP and predict the @entity2 of soft tissues with MIA. Three months after the first surgery, 3D laser scanning was conducted to evaluate the volume of surviving fat. @entity0 characteristics, satisfaction, and soft tissue augmentation results were analyzed. RESULTS: Twenty-seven cases (9 @entity0 and 18 @entity0 ) with @entity3 were included and treated using serial AFG (mean number of operation, 3.1 times). The mean age was 22.1 years. With 3D CT or 3D laser-scanning camera and MIA, we obtained the mean deficient volume of the affected area (30.48 mm) and the mean volume of the total fat injection (133.61 mm). The mean fat absorption ratio was 47.92%. The mean satisfaction score immediately obtained at first postoperative (score = 4.3) was higher than that at 3 months postoperatively (score = 4.1) and 12 months postoperatively (score = 4.0). No complications and donor-site morbidity were noted. CONCLUSION: The facial symmetry of @entity0 with centered FMP can be successfully restored using serial AFG alone. The combined 3D and MIA can be used to predict the @entity2 of soft tissues and objectively evaluate the survival of grafted fat.

title: Autologous Fat Grafting With Combined 3-Dimensional and Mirror-Image Analyses for Progressive XXXX .

answer: @entity3


abstract: Despite angiographically successful opening of an @entity3 -related vessel within a 6-hour time frame, some @entity0 do not recover left ventricular regional wall function in the @entity3 zone after an @entity1 ( @entity1 ). Recent evidence suggests that this finding is due to the no-reflow phenomenon, or failure to recover tissue perfusion despite @entity0 epicardial arteries. We performed myocardial contrast echocardiography to assess tissue perfusion before and after opening of an @entity3 . Coronary angiograms, regional wall motion scoring, and myocardial contrast enhancement were graded by 3 observers. Of 24 @entity0 with @entity1 , 7 (29%) failed to recover tissue perfusion in > or = 1 region of myocardium. Of 106 regions subtended by the @entity3 , 16 (15%), 43 (41%), and 47 (44%) regions had no-reflow, partial, or normal flow, respectively, after arterial patency was established. There was a spectrum of reperfusion patterns ranging from no-reflow to normal perfusion. One-month follow-up angiographic and myocardial contrast echocardiographic studies were performed in 12 of the 24 @entity0 . At 1 month, all segments of myocardium that had immediate normal perfusion had regained normal wall motion. In contrast, 17 segments that had partial or no-reflow were identified. Of these 17, 3 regained normal function, 10 segments were @entity5 , and 4 segments were @entity4 . We conclude that myocardial contrast echocardiography can be used to identify the no-reflow phenomenon in up to 29% of @entity0 with @entity1 . Additionally, we found that the immediate-reflow pattern can predict degree of @entity2 at 1-month follow-up.

title: Ability of the no-reflow phenomenon during an @entity1 to predict XXXX at one-month follow-up.

answer: @entity2


abstract: Despite angiographically successful opening of an @entity3 -related vessel within a 6-hour time frame, some @entity0 do not recover left ventricular regional wall function in the @entity3 zone after an @entity1 ( @entity1 ). Recent evidence suggests that this finding is due to the no-reflow phenomenon, or failure to recover tissue perfusion despite @entity0 epicardial arteries. We performed myocardial contrast echocardiography to assess tissue perfusion before and after opening of an @entity3 . Coronary angiograms, regional wall motion scoring, and myocardial contrast enhancement were graded by 3 observers. Of 24 @entity0 with @entity1 , 7 (29%) failed to recover tissue perfusion in > or = 1 region of myocardium. Of 106 regions subtended by the @entity3 , 16 (15%), 43 (41%), and 47 (44%) regions had no-reflow, partial, or normal flow, respectively, after arterial patency was established. There was a spectrum of reperfusion patterns ranging from no-reflow to normal perfusion. One-month follow-up angiographic and myocardial contrast echocardiographic studies were performed in 12 of the 24 @entity0 . At 1 month, all segments of myocardium that had immediate normal perfusion had regained normal wall motion. In contrast, 17 segments that had partial or no-reflow were identified. Of these 17, 3 regained normal function, 10 segments were @entity5 , and 4 segments were @entity4 . We conclude that myocardial contrast echocardiography can be used to identify the no-reflow phenomenon in up to 29% of @entity0 with @entity1 . Additionally, we found that the immediate-reflow pattern can predict degree of @entity2 at 1-month follow-up.

title: Ability of the no-reflow phenomenon during an XXXX to predict @entity2 at one-month follow-up.

answer: @entity1


abstract: OBJECTIVES: Transjugular intrahepatic portosystemic stent-shunts (TIPSS) have been shown to reduce portal @entity3 consistently and have recently been reported to @entity5 . This retrospective and nonrandomized study compares the results of TIPSS with esophageal transection (ET) and devascularization in @entity0 with uncontrolled @entity5 admitted to a single center with an interest in variceal @entity5 . @entity0 AND METHODS: Two hundred and sixty cirrhotic @entity0 have been referred with variceal @entity5 over the past 7 yr. In 41 @entity0 (15.8%), @entity5 was uncontrolled despite two treatments with sclerotherapy. Thirty-eight @entity0 were eligible for analysis. Nineteen were considered for ET and 19 for TIPSS. @entity0 in the two groups were well matched for age, sex, etiology of @entity4 , and its severity and complications. They have been followed for 13 @entity0 years (TIPSS-7, longest 20 months; ET-6, longest 23 months). Data for survival and rebleeding were analyzed by the Kaplan-Meier method on an intention-to-treat basis. RESULTS: Seven of the 19 were considered unfit for surgery, and 12 underwent esophageal transection and devascularization. TIPSS was undertaken successfully in 17 @entity0 , the Palmaz stent being used in 4 and the Wallstent in 13. Successful TIPSS reduced the mean portal pressure gradient from 22.2 (SE 1.2) to 9.7 (SE 0.7) mm Hg (p < 0.001). Mortality within 30 days of the initial bleed was 42% in the TIPSS group compared with 79% in the ET group (p < 0.05). Rebleeding occurred in 15.6% @entity0 with TIPSS, compared with 26.2% in the ET group. @entity1 in the two groups of @entity0 was not significantly different (TIPSS 25% and ET 22%). TIPSS was followed by active infection in 20% compared with 36% after ET. CONCLUSIONS: This study shows that the overall mortality in this group of @entity0 is high whatever the type of treatment used. TIPSS can be performed successfully on these @entity0 who are often not suitable for surgery. Mortality rates were significantly lower in @entity0 treated by TIPSS. Compared with ET, TIPSS should be regarded as the preferred mode of treatment for uncontrolled @entity5 in @entity0 with @entity2 .

title: A comparative study of emergency transjugular intrahepatic portosystemic stent-shunt and esophageal transection in the management of uncontrolled XXXX .

answer: @entity5


abstract: A 53-year-old @entity0 presented with a right breast lump identified approximately 6 months previously on palpation. Because the lump gradually increased in size, she initially visited a general practitioner who referred her to our hospital. Mammography and breast ultrasonography revealed a lesion in the right breast. Biopsy indicated a case ofstromal @entity2 . Three months later, another lesion was detected, and simple mastectomy was performed. A recurrent lesion was detected after 1 month, and lumpectomy was performed. Another mass developed 1 month later, and extirpation was performed. After 1 month, another mass was detected, and extirpation was performed again. The stump was negative for lesions and recurrences. A thorough examination did not reveal @entity1 to remote organs. There are no established therapies for @entity3 . Surgical excision is undoubtedly indicated, as observed in this @entity0 who showed multiple recurrent lesions despite the surgeries performed.

title: [A case of XXXX with multiple local recurrences].

answer: @entity3


abstract: We retrospectively evaluated the clinical outcomes of 192 consecutive @entity0 with local recurrence after complete resection of @entity3 (NSCLC). The initial local recurrent site was the resection stump in 5 @entity0 (the chest wall in 3 @entity0 , mediastinum in 1 @entity0 , and diaphragm in 1 @entity0 ), and the hilar and/or mediastinal lymph node (HMLN)in 17 @entity0 . The sites of distant @entity1 were the lungs in 10 @entity0 , pleura in 4 @entity0 , brain in 7 @entity0 , liver in 5 @entity0 , bone in 4 @entity0 , and other sites in 4 @entity0 . Treatments after initial recurrence included surgery in 2 @entity0 , radiotherapy in 5 @entity0 , chemotherapy in 9 @entity0 , and chemo-radiotherapy in 5 @entity0 . Only 1 @entity0 received supportive care. The response to radiotherapy was a complete response(CR)in 1 @entity0 , partial response(PR)in 5 @entity0 , stable disease( @entity2 )in 3 @entity0 , and progressive disease( @entity4 )in 1 @entity0 . The best response of all lines of chemotherapy was CR in 3 @entity0 , PR in 4 @entity0 , @entity2 in 3 @entity0 , and @entity4 in 4 @entity0 . The median post-recurrence survival(PRS)time with local recurrence was better than that with distant @entity1 (23 vs 14 months); however, the best PRS was obtained in @entity0 with recurrence in the lungs(29 months). A CR for more than 2 years was obtained in 1 @entity0 after surgery, in 1 @entity0 after radiotherapy, and in 2 @entity0 after chemotherapy. Although local recurrence of resected NSCLC can be potentially controlled by using local treatments - such as surgery and radiotherapy - or systemic chemotherapy, curative aggressive treatment should be considered when required.

title: [Post-recurrence survival after surgical resection of XXXX with local recurrence].

answer: @entity3


abstract: Epithelial tight junctions form a regulated barrier that seals the paracellular space and prevents mixing of luminal contents with the interstitium. This barrier is composed of a group of proteins including the putative "sealing" protein @entity1 that appears to bind directly to a cytoplasmic junction protein, @entity2 . To study the interaction and regulation of these two components when paracellular integrity is altered, we assessed protein expression and immunofluorescent (IF) localization of @entity2 and @entity1 in a @entity0 model of hepatocyte tight junction damage induced by common bile duct ligation (CBDL). Protein levels were detected in liver by immunoblotting and IF localization by 3-dimensional reconstruction of serial 0.5-micron confocal microscopic optical sections. As previously described, @entity2 protein levels progressively increased to threefold control levels 9 days after CBDL. In contrast, @entity1 protein levels decreased by 50% within 2 days after CBDL and returned to control values by 9 days. In control IF sections, @entity3 colocalized, forming thin continuous staining outlining canaliculi. After CBDL, @entity2 staining appeared discontinuous, and a punctate pericanalicular accumulation of signal developed around junctional areas. @entity1 staining was also discontinuous after CBDL, but, in contrast to @entity2 , was not punctate and remained localized either in a linear fashion along canalicular margins or in a homogeneous fashion in immediately surrounding areas. CBDL results in changes in the expression and localization of the putative tight junction sealing protein @entity1 in hepatocytes that are distinct from those observed for the peripheral membrane tight junction protein @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Altered hepatic localization and expression of XXXX after common bile duct ligation.

answer: @entity1


abstract: A @entity0 in his 60s was diagnosed with @entity4 and underwent distal gastrectomy and D2 lymph node dissection. The histological diagnosis was @entity5 (T3, N1, StageIIB). He was treated with @entity6 as adjuvant chemotherapy for 1 year. One year and 2 months after gastrectomy, a computed tomography(CT)scan revealed liver @entity1 (S8, 38mm). The @entity0 was diagnosed with liver @entity1 (refractory to @entity6 ), and administered combination chemotherapy with irinotecan and cisplatin. After 4 courses of treatment, a CT scan detected a progressive @entity3 (55mm). Combination chemotherapy with docetaxel and @entity6 was selected as second-line chemotherapy. After 6 courses of treatment, the @entity2 size reduced to 40mm in diameter, and no other @entity1 was detected. Nine months after the diagnosis of liver @entity1 , partial resection of the liver(S8)was performed. A pathological diagnosis of @entity5 was determined, and the pathological therapeutic effect was rated as Grade 1b. Combination chemotherapy with docetaxel and @entity6 was found to be effective, and was thus administrated after the operation. There have been no signs of recurrence for 6 months after the operation. Surgery with perioperative chemotherapy can be an effective treatment for liver @entity1 from @entity4 .

title: [A case of metastatic @entity3 arising from XXXX resected after second-line chemotherapy].

answer: @entity4


abstract: A @entity0 in his 60s was diagnosed with @entity4 and underwent distal gastrectomy and D2 lymph node dissection. The histological diagnosis was @entity5 (T3, N1, StageIIB). He was treated with @entity6 as adjuvant chemotherapy for 1 year. One year and 2 months after gastrectomy, a computed tomography(CT)scan revealed liver @entity1 (S8, 38mm). The @entity0 was diagnosed with liver @entity1 (refractory to @entity6 ), and administered combination chemotherapy with irinotecan and cisplatin. After 4 courses of treatment, a CT scan detected a progressive @entity3 (55mm). Combination chemotherapy with docetaxel and @entity6 was selected as second-line chemotherapy. After 6 courses of treatment, the @entity2 size reduced to 40mm in diameter, and no other @entity1 was detected. Nine months after the diagnosis of liver @entity1 , partial resection of the liver(S8)was performed. A pathological diagnosis of @entity5 was determined, and the pathological therapeutic effect was rated as Grade 1b. Combination chemotherapy with docetaxel and @entity6 was found to be effective, and was thus administrated after the operation. There have been no signs of recurrence for 6 months after the operation. Surgery with perioperative chemotherapy can be an effective treatment for liver @entity1 from @entity4 .

title: [A case of metastatic XXXX arising from @entity4 resected after second-line chemotherapy].

answer: @entity3


abstract: Abstract Objective: To evaluate wideband amplification and non-linear frequency compression (NLFC) as a means to improve speech recognition for @entity0 with mild/moderate @entity1 . DESIGN: Randomized within-subject design with repeated measures across test conditions. STUDY SAMPLE: Eleven @entity0 with mild to moderate @entity1 were evaluated with: (1) Phonak BTE without NLFC, (2) Phonak BTE with NLFC, and (3) Oticon BTE with wideband response extending to 8000 Hz. RESULTS: Use of NLFC provided better detection and recognition of high-frequency stimuli (e.g. /sh/ and /s/). No difference in performance between conditions was observed for speech recognition when measured with the University of Western Ontario (UWO) plurals test and the UWO distinctive features difference test. Finally, there were no differences between conditions on the BKB-SIN test. CONCLUSIONS: @entity0 with mild to moderate @entity1 have good access to high-frequency phonemes presented at fixed levels (e.g. 50 to 60 dBA) with both wideband and NLFC technology. Similarly, sentence recognition in noise was similar with wideband and NLFC. Adaptive test procedures that probe performance at lower input levels showed small but significant improvements in the detection and recognition of the phonemes /s/ and /sh/ with NLFC condition when compared to the NLFC Off and wideband conditions.

title: Evaluation of wideband frequency responses and non-linear frequency compression for XXXX with mild to moderate high-frequency hearing loss.

answer: @entity0


abstract: BACKGROUND: Galvanization is the process of coating steel or cast iron pieces with a thin layer of @entity0 allowing protection against corrosion. One of the important hazards in this industry is exposure to @entity0 compounds specially @entity4 fumes and dusts. In this study we evaluated chronic effects of @entity4 on the respiratory tract of galvanizers. METHODS: 188 workers were selected from a galvanization plant, 71 galvanizers as exposed group and 117 workers from other departments of plants as control group. Information was collected using American @entity2 Society (ATS) standard questionnaire, physical examination and demographic data sheet. Pulmonary function tests were measured for all subjects. Exposure assessment was done with NIOSH 7030 method. RESULTS: The Personal Breathing Zone (PBZ) air sampling results for @entity0 ranged from 6.61 to 8.25 mg/m   above the permissible levels (Time weighted average; @entity5 mg/m  ). Results showed that the prevalence of the respiratory symptoms such as @entity1 , throat and nose irritation in the exposed group was significantly more than the control group. Decreasing in average percent in all spirometric parameters were seen in the galvanizers who exposed to @entity4 fumes and dusts. The prevalence of obstructive @entity3 was significantly higher in the exposed group. CONCLUSIONS: Results suggest that high workplace @entity0 levels are associated with an increase in @entity3 in galvanizers.

title: Respiratory Symptoms and Pulmonary Function Tests among Galvanized Workers Exposed To XXXX .

answer: @entity4


abstract: UNASSIGNED: Depression remains a great societal burden and a major treatment challenge. Most antidepressant medications target serotonergic raph   nuclei. Acute @entity4 depletion (ATD) modulates @entity2 function. To better understand the raph  's role in mood networks, we studied raph   functional connectivity in @entity1 . Fifteen @entity1 @entity0 were treated with @entity3 for 12 weeks and scanned during ATD and sham conditions. Based on our previous findings in a separate cohort, resting state MRI functional connectivity between raph   and other @entity1 -related regions (ROIs) was analyzed in narrow frequency bands. ATD decreased raph   functional connectivity with the bilateral thalamus within 0.025-0.05Hz, and also decreased raph   functional connectivity with the right pregenual anterior cingulate cortex within 0.05-0.1Hz. Using the control broadband filter 0.01-0.1Hz, no significant differences in raph  -ROI functional connectivity were observed. Post-hoc analysis by remission status suggested increased raph   functional connectivity with left pregenual anterior cingulate cortex in remitters (n=10) and decreased raph   functional connectivity with left thalamus in non-remitters (n=5), both within 0.025-0.05Hz. Reducing @entity2 function appears to alter coordination of these mood-related networks in specific, low frequency ranges. For examination of effects of reduced @entity2 function on mood-related networks, specific low frequency BOLD fMRI signals can identify regions implicated in neural circuitry and may enable clinically-relevant interpretation of functional connectivity measures. The biological significance of these low frequency signals detected in the raph   merits further study.

title: Effects of acute @entity4 depletion on raph   functional connectivity in XXXX .

answer: @entity1


abstract: UNASSIGNED: Depression remains a great societal burden and a major treatment challenge. Most antidepressant medications target serotonergic raph   nuclei. Acute @entity4 depletion (ATD) modulates @entity2 function. To better understand the raph  's role in mood networks, we studied raph   functional connectivity in @entity1 . Fifteen @entity1 @entity0 were treated with @entity3 for 12 weeks and scanned during ATD and sham conditions. Based on our previous findings in a separate cohort, resting state MRI functional connectivity between raph   and other @entity1 -related regions (ROIs) was analyzed in narrow frequency bands. ATD decreased raph   functional connectivity with the bilateral thalamus within 0.025-0.05Hz, and also decreased raph   functional connectivity with the right pregenual anterior cingulate cortex within 0.05-0.1Hz. Using the control broadband filter 0.01-0.1Hz, no significant differences in raph  -ROI functional connectivity were observed. Post-hoc analysis by remission status suggested increased raph   functional connectivity with left pregenual anterior cingulate cortex in remitters (n=10) and decreased raph   functional connectivity with left thalamus in non-remitters (n=5), both within 0.025-0.05Hz. Reducing @entity2 function appears to alter coordination of these mood-related networks in specific, low frequency ranges. For examination of effects of reduced @entity2 function on mood-related networks, specific low frequency BOLD fMRI signals can identify regions implicated in neural circuitry and may enable clinically-relevant interpretation of functional connectivity measures. The biological significance of these low frequency signals detected in the raph   merits further study.

title: Effects of acute XXXX depletion on raph   functional connectivity in @entity1 .

answer: @entity4


abstract: BACKGROUND: Concurrent chemoradiotherapy is the current standard treatment for inoperable @entity1 ( @entity4 ). In this study we aimed to investigate the efficacy and @entity2 of CCRT with split dose of @entity3 (30 mg/m2) and @entity5 (20 mg/m2) in @entity0 with inoperable @entity1 followed in our oncology clinic. MATERIAL AND METHODS: Medical records of 97 @entity0 with inoperable @entity1 treated with concurrent chemoradiotherapy with @entity3 - @entity5 were retrospectively analyzed. @entity3 (30 mg/m2) and @entity5 (20 mg/m2) were administered on days 1, 8, 22, and 29 during radiotherapy. Two cycles of consolidation chemotherapy were given. All @entity0 data, including pathological, clinical, radiological, biochemical, and hematological data, were assessed retrospectively using our database system. RESULTS: Our study included 97 unresectable @entity1 @entity0 who were treated with CCRT. Median age was 58 years old (range 39-75) and 87 (89.7%) of the @entity0 were @entity0 . ECOG performance score was 0-1 in 93 @entity0 (95.9%). Squamous histology, the most common histology, was diagnosed in 46 @entity0 (47.4%). Median follow-up time was 23.8 months. Median progression-free survival (PFS) and median overall survival time (OS) were 10.3 months and 17.8 months, respectively. Objective response rate and clinical benefit rate were 75.3% and 83.5%, respectively. Distant and local relapse rate were 57.1% and 42.9%, respectively. Hematological and non-hematological grade 3-4 @entity2 were seen in 13 (13.4%) and 16 (16.5%) @entity0 , respectively. Six (6.1%) @entity0 died due to @entity2 . CONCLUSIONS: The results of this study suggest that split-dose @entity3 may offer fewer grade III-IV @entity2 without sacrificing efficacy and could be an option in @entity0 with inoperable @entity1 during CCRT. Similar to past studies, despite high response rate during CCRT, distant relapse is the major parameter that influences @entity0 survival in long-term in @entity4 .

title: Concurrent chemoradiotherapy with @entity5 plus split-dose XXXX may be an option in inoperable @entity1 : a single-center experience.

answer: @entity3


abstract: BACKGROUND: Concurrent chemoradiotherapy is the current standard treatment for inoperable @entity1 ( @entity4 ). In this study we aimed to investigate the efficacy and @entity2 of CCRT with split dose of @entity3 (30 mg/m2) and @entity5 (20 mg/m2) in @entity0 with inoperable @entity1 followed in our oncology clinic. MATERIAL AND METHODS: Medical records of 97 @entity0 with inoperable @entity1 treated with concurrent chemoradiotherapy with @entity3 - @entity5 were retrospectively analyzed. @entity3 (30 mg/m2) and @entity5 (20 mg/m2) were administered on days 1, 8, 22, and 29 during radiotherapy. Two cycles of consolidation chemotherapy were given. All @entity0 data, including pathological, clinical, radiological, biochemical, and hematological data, were assessed retrospectively using our database system. RESULTS: Our study included 97 unresectable @entity1 @entity0 who were treated with CCRT. Median age was 58 years old (range 39-75) and 87 (89.7%) of the @entity0 were @entity0 . ECOG performance score was 0-1 in 93 @entity0 (95.9%). Squamous histology, the most common histology, was diagnosed in 46 @entity0 (47.4%). Median follow-up time was 23.8 months. Median progression-free survival (PFS) and median overall survival time (OS) were 10.3 months and 17.8 months, respectively. Objective response rate and clinical benefit rate were 75.3% and 83.5%, respectively. Distant and local relapse rate were 57.1% and 42.9%, respectively. Hematological and non-hematological grade 3-4 @entity2 were seen in 13 (13.4%) and 16 (16.5%) @entity0 , respectively. Six (6.1%) @entity0 died due to @entity2 . CONCLUSIONS: The results of this study suggest that split-dose @entity3 may offer fewer grade III-IV @entity2 without sacrificing efficacy and could be an option in @entity0 with inoperable @entity1 during CCRT. Similar to past studies, despite high response rate during CCRT, distant relapse is the major parameter that influences @entity0 survival in long-term in @entity4 .

title: Concurrent chemoradiotherapy with XXXX plus split-dose @entity3 may be an option in inoperable @entity1 : a single-center experience.

answer: @entity5


abstract: BACKGROUND: Concurrent chemoradiotherapy is the current standard treatment for inoperable @entity1 ( @entity4 ). In this study we aimed to investigate the efficacy and @entity2 of CCRT with split dose of @entity3 (30 mg/m2) and @entity5 (20 mg/m2) in @entity0 with inoperable @entity1 followed in our oncology clinic. MATERIAL AND METHODS: Medical records of 97 @entity0 with inoperable @entity1 treated with concurrent chemoradiotherapy with @entity3 - @entity5 were retrospectively analyzed. @entity3 (30 mg/m2) and @entity5 (20 mg/m2) were administered on days 1, 8, 22, and 29 during radiotherapy. Two cycles of consolidation chemotherapy were given. All @entity0 data, including pathological, clinical, radiological, biochemical, and hematological data, were assessed retrospectively using our database system. RESULTS: Our study included 97 unresectable @entity1 @entity0 who were treated with CCRT. Median age was 58 years old (range 39-75) and 87 (89.7%) of the @entity0 were @entity0 . ECOG performance score was 0-1 in 93 @entity0 (95.9%). Squamous histology, the most common histology, was diagnosed in 46 @entity0 (47.4%). Median follow-up time was 23.8 months. Median progression-free survival (PFS) and median overall survival time (OS) were 10.3 months and 17.8 months, respectively. Objective response rate and clinical benefit rate were 75.3% and 83.5%, respectively. Distant and local relapse rate were 57.1% and 42.9%, respectively. Hematological and non-hematological grade 3-4 @entity2 were seen in 13 (13.4%) and 16 (16.5%) @entity0 , respectively. Six (6.1%) @entity0 died due to @entity2 . CONCLUSIONS: The results of this study suggest that split-dose @entity3 may offer fewer grade III-IV @entity2 without sacrificing efficacy and could be an option in @entity0 with inoperable @entity1 during CCRT. Similar to past studies, despite high response rate during CCRT, distant relapse is the major parameter that influences @entity0 survival in long-term in @entity4 .

title: Concurrent chemoradiotherapy with @entity5 plus split-dose @entity3 may be an option in inoperable XXXX : a single-center experience.

answer: @entity1


abstract: BACKGROUND: Operative complications occur more frequently, often are more preventable, and their consequences can be more severe than other types of complications. Controversy exists regarding how best to identify and predict @entity1 . Several studies on predictive factors for @entity1 focused on a specific predictor for a specific outcome. To develop a reliable tool to identify @entity0 with @entity1 , insight in predictive factors for @entity1 is required. @entity0 AND METHODS: We searched all publications addressing predictive factors for the development of @entity1 in adult @entity0 admitted to the gastrointestinal, vascular, or general surgery departments. Data were extracted regarding study design, @entity0 characteristics, operative specialty, types of operative procedures, types of complications, possible predictors, and associated complication risk increase (expressed as an odds ratio; OR). RESULTS: The final set of 30 articles yielded a total of 53 predictive factors studied in various settings, operative specialties, and disorders. To focus our analysis we selected the 25 most robust and clinically applicable factors (ie, appearing in 3 or more studies). These factors were then categorized into 4 different groups: @entity0 -related factors, Co-morbidities, Laboratory values, and Surgery-related factors. The most predictive factors for morbidity in these groups were body mass index (ORs from 1.80 to 6.30), age (1.02-4.62  years), American Society of Anesthesiologists classification (1.77-7.10), @entity3 (1.23-1.30), serum @entity2 (1.39-2.14), emergency surgery (1.50-2.54), and functional status (1.36-4.07). CONCLUSION: This review presents a set of factors predictive of @entity1 for general surgery departments. These easily retrievable factors can and should be validated in the specific @entity0 populations of each hospital.

title: XXXX : A  systematic review.

answer: @entity1


abstract: OBJECTIVE: To evaluate in long-term periods the destruction of periodontal tissues and bacterial colonization induced by oral gavage with periodontopathogens or ligature @entity5 models. MATERIAL AND METHODS: Forty-eight C57BL/6  J @entity1 were divided into four groups: group C: negative control; group L: ligature; group G-Pg: oral gavage with @entity7 ; and group G-PgFn: oral gavage with @entity7 associated with @entity8 . @entity1 were infected by oral gavage five times in 2-day intervals. After 45 and 60  days, animals were sacrificed and the immune-inflammatory response in the periodontal tissue was assessed by stereometric analysis. The @entity3 was evaluated by live microcomputed tomography and histometric analysis. qPCR was used to confirm the bacterial colonization in all the groups. Data were analyzed using the Kruskal-Wallis, Wilcoxon, and ANOVA tests, at 5  % of significance level. RESULTS: Ligature model induced @entity2 and bone resorption characterized by increased number of inflammatory cells and decreased number of fibroblasts, followed by @entity3 at 45 and 60  days (p   <   0.05). Bacterial colonization in groups G-Pg and G-PgFn was confirmed by qPCR but @entity2 and bone resorption were not observed (p   <   0.05). CONCLUSIONS: The ligature model but not the oral gavage models were effective to induce @entity2 and @entity3 in long-term periods. @entity9 colonization was observed in all models of @entity5 induction, independent of tissue alterations. These @entity1 models of @entity6 validates, compliments, and enhances published @entity4 models that utilize ligature or oral gavage and supports the importance of a successful colonization of a susceptible host, a bacterial invasion into vulnerable tissue, and host-bacterial interactions that lead to tissue destruction. CLINICAL RELEVANCE: The ligature model was an effective approach to induce @entity2 and @entity3 similar to @entity0 @entity6 , but the oral gavage models were not efficient in inducing periodontal @entity2 and tissue destruction in the conditions studied. Ligature models can provide a basis for future interventional studies that contribute to the understanding of the disease pathogenesis and the complex host response to microbial challenge.

title: Long-term evaluation of oral gavage with periodontopathogens or ligature induction of XXXX in @entity1 .

answer: @entity5


abstract: OBJECTIVE: To evaluate in long-term periods the destruction of periodontal tissues and bacterial colonization induced by oral gavage with periodontopathogens or ligature @entity5 models. MATERIAL AND METHODS: Forty-eight C57BL/6  J @entity1 were divided into four groups: group C: negative control; group L: ligature; group G-Pg: oral gavage with @entity7 ; and group G-PgFn: oral gavage with @entity7 associated with @entity8 . @entity1 were infected by oral gavage five times in 2-day intervals. After 45 and 60  days, animals were sacrificed and the immune-inflammatory response in the periodontal tissue was assessed by stereometric analysis. The @entity3 was evaluated by live microcomputed tomography and histometric analysis. qPCR was used to confirm the bacterial colonization in all the groups. Data were analyzed using the Kruskal-Wallis, Wilcoxon, and ANOVA tests, at 5  % of significance level. RESULTS: Ligature model induced @entity2 and bone resorption characterized by increased number of inflammatory cells and decreased number of fibroblasts, followed by @entity3 at 45 and 60  days (p   <   0.05). Bacterial colonization in groups G-Pg and G-PgFn was confirmed by qPCR but @entity2 and bone resorption were not observed (p   <   0.05). CONCLUSIONS: The ligature model but not the oral gavage models were effective to induce @entity2 and @entity3 in long-term periods. @entity9 colonization was observed in all models of @entity5 induction, independent of tissue alterations. These @entity1 models of @entity6 validates, compliments, and enhances published @entity4 models that utilize ligature or oral gavage and supports the importance of a successful colonization of a susceptible host, a bacterial invasion into vulnerable tissue, and host-bacterial interactions that lead to tissue destruction. CLINICAL RELEVANCE: The ligature model was an effective approach to induce @entity2 and @entity3 similar to @entity0 @entity6 , but the oral gavage models were not efficient in inducing periodontal @entity2 and tissue destruction in the conditions studied. Ligature models can provide a basis for future interventional studies that contribute to the understanding of the disease pathogenesis and the complex host response to microbial challenge.

title: Long-term evaluation of oral gavage with periodontopathogens or ligature induction of @entity5 in XXXX .

answer: @entity1


abstract: Lag screw osteosynthesis is a well proven technique. Its application is limited by the fact that the spherical head of the screw act as wedge. Combining this screw with a bioconcave washer has broadened the range of applications for lag screw osteosynthesis in the maxillofacial region. PURPOSE: The aim of the study was to compare the efficacy of anchor lag screw with conventional lag screw in @entity1 . @entity0 AND METHOD: Thirty @entity0 with anterior mandible @entity1 with no concomitant @entity1 , @entity2 or extraoral communication, who visited our outpatient Department of Oral and Maxillofacial Surgery, were included in the study after obtaining their informed consent. @entity0 were randomly divided into two groups; where Group A underwent fixation using conventional lag screw and Group B anchor lag screw. The fixation system used included 2  mm @entity3 lag screws of sizes 25  mm, 27  mm and 30  mm and 3  mm @entity3 bioconcave washer. At each follow up visit, clinical data was collected detailing clinical presentation of healing and radiographic findings. RESULTS: Radiographic features at post surgery evaluation indicated loss of bone contact around the screw head and bone resorption in five @entity0 of Group A, thus causing loosening of lag screw whereas none of the @entity0 in Group B, was found to have any such complication. CONCLUSIONS: The findings support the hypothesis that bioconcave washer aids in holding up the farthest fragment at the interface of the @entity1 fragment. Application of bioconcave washer provides easy loading of lag screw.

title: Anchor lag screw vs conventional lag screw in mandibular XXXX : A series of 30 cases.

answer: @entity1


abstract: STATEMENT OF PROBLEM: Auricular swellings significantly affect the facial aesthetics. Swelling affecting the pinna can lead to overt disfigurement and change the entire appeal of the face. @entity1 can occur because of a delay in diagnosis and mismanagement. In our clinical trial fabrication of a simple, effective innovative pressure appliance for @entity2 is presented to prevent such changes. METHOD: Our case report comprises of a new clinical trial on a @entity0 with @entity2 referred from the department of ENT, M.S. Ramaiah medical hospital, Bangalore, Karnataka. A 19-gauge stainless steel wire (Leo wire, Leone, Italy) and chemically cure resin was used to fabricate the pressure appliance to prevent the recurrence of @entity2 . RESULT: @entity0 was successfully treated with the help of pressure appliance after 8 weeks of follow up. CONCLUSION: This appliance is a masked alternative to conventional pressure dressing after @entity2 which does not pose embarrassment for @entity0 to apply. The use of such an appliance will ensure @entity0 compliance, thereby preventing long term @entity1 .

title: Pressure appliance to prevent the recurrence of XXXX : A  new clinical trial.

answer: @entity2