abstract: BACKGROUND: Researchers have reported that sleep duration is positively related to baseline neurocognitive performance. However, researchers have yet to examine the effect of preinjury @entity1 on postconcussion impairments. PURPOSE: To compare @entity3 and symptoms of athletes with preinjury @entity1 to those without after a sport-related concussion (SRC). STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: The sample included 348 adolescent and adult athletes (age, mean    SD, 17.43    2.34 years) with a diagnosed SRC. The sample was divided into 2 groups: (1) 34 (10%) @entity0 with preinjury @entity1 (sleeping less as well as having @entity4 ; SLEEP SX) and (2) 231 (66%) @entity0 without preinjury @entity1 (CONTROL). The remaining 84 (24%) @entity0 with minimal @entity1 (1 symptom) were excluded. @entity0 completed the Immediate Postconcussion Assessment and Cognitive Test (ImPACT) and Postconcussion Symptom Scale (PCSS) at baseline and 3 postinjury intervals (2, 5-7, and 10-14 days after injury). A series of repeated-measures analyses of covariance with Bonferroni correction, controlling for baseline non-sleep-related symptoms, were conducted to compare postinjury neurocognitive performance between groups. Follow-up exploratory t tests examined between-group differences at each time interval. A series of analyses of variance were used to examine total PCSS score, sleep-related, and non-sleep-related symptoms across time intervals between groups. RESULTS: Groups differed significantly in PCSS scores across postinjury intervals for reaction time (P < .001), with the preinjury SLEEP SX group performing worse than controls at 5-7 days (mean    SD, 0.70    0.32 [SLEEP SX], 0.60    0.14 [CONTROL]) and 10-14 days (0.61    0.17 [SLEEP SX]; 0.57    0.10 [CONTROL]) after injury. Groups also differed significantly on verbal memory performance (P = .04), with the SLEEP SX (68.21    18.64) group performing worse than the CONTROL group (76.76    14.50) 2 days after injury. The SLEEP SX group reported higher total symptom (P = .02) and sleep-related symptom (P = .02) scores across postinjury time intervals. CONCLUSION: Preinjury @entity1 may exacerbate @entity3 and symptoms after concussion. The findings may help clinicians identify athletes who are at risk for @entity2 after a concussion due to preinjury @entity1 .

title: The Effect of Preinjury Sleep XXXX and Symptoms After Sport-Related Concussion.

answer: @entity2


abstract: UNASSIGNED: Non-ionizing radiation at 2.45   GHz may modify the morphology and expression of genes that codify @entity3 proteins (HSP) in the thyroid gland. Diathermy is the therapeutic application of non-ionizing radiation to @entity0 for its beneficial effects in @entity2 processes. We used a diathermy model on @entity1 subjected to maximum exposure in the left front leg, in order to study the effects of radiation on the nearby thyroid tissue. Fifty-six @entity1 were individually exposed once or repeatedly (10 times in two weeks) for 30   min to 2.45   GHz radiation in a commercial chamber at different non-thermal specific absorption rates ( @entity5 ), which were calculated using the finite difference time domain technique. We used immunohistochemistry methods to study the expression of @entity6 and morphological changes in thyroid gland tissues. Ninety minutes after radiation with the highest SAR, the central and peripheral follicles presented increased size and the thickness of the peripheral septa had decreased. Twenty-four hours after radiation, only peripheral follicles radiated at 12   W were found to be smaller. Peripheral follicles increased in size with repeated exposure at 3   W power. Morphological changes in the thyroid tissue may indicate a glandular response to acute or repeated stress from radiation in the @entity4 . Further research is needed to determine if the effect of this physical agent over time may cause disease in the @entity0 thyroid gland.

title: Exposure to non-ionizing radiation provokes changes in @entity1 thyroid morphology and expression of XXXX .

answer: @entity6


abstract: UNASSIGNED: Non-ionizing radiation at 2.45   GHz may modify the morphology and expression of genes that codify @entity3 proteins (HSP) in the thyroid gland. Diathermy is the therapeutic application of non-ionizing radiation to @entity0 for its beneficial effects in @entity2 processes. We used a diathermy model on @entity1 subjected to maximum exposure in the left front leg, in order to study the effects of radiation on the nearby thyroid tissue. Fifty-six @entity1 were individually exposed once or repeatedly (10 times in two weeks) for 30   min to 2.45   GHz radiation in a commercial chamber at different non-thermal specific absorption rates ( @entity5 ), which were calculated using the finite difference time domain technique. We used immunohistochemistry methods to study the expression of @entity6 and morphological changes in thyroid gland tissues. Ninety minutes after radiation with the highest SAR, the central and peripheral follicles presented increased size and the thickness of the peripheral septa had decreased. Twenty-four hours after radiation, only peripheral follicles radiated at 12   W were found to be smaller. Peripheral follicles increased in size with repeated exposure at 3   W power. Morphological changes in the thyroid tissue may indicate a glandular response to acute or repeated stress from radiation in the @entity4 . Further research is needed to determine if the effect of this physical agent over time may cause disease in the @entity0 thyroid gland.

title: Exposure to non-ionizing radiation provokes changes in XXXX thyroid morphology and expression of @entity6 .

answer: @entity1


abstract: OBJECTIVE: Organ donation with scheduled @entity5 after @entity7 (s-DBCD) is a special category in China. This study was to evaluate the procedure of pediatric s-DBCD, graft quality, and clinical outcomes of single kidney transplantation. METHODS: We retrospectively analyzed the data of 8 Chinese pediatric donors. RESULTS: The death causes of the donors (age 4-12 years) were @entity10 after cardiopulmonary resuscitation (n  = 1), @entity6 (n  = 1), severe @entity3 (n  = 3), and @entity2 (n  = 3). The functional warm @entity1 time of the grafts was 18 (13-26) minutes. Sixteen kidneys were recovered using liver-kidney en bloc procurement after in situ perfusion. All kidneys had a length >7 cm and were transplanted to 3 adolescent and 13 adult recipients. Two cases of delayed graft function occurred. The @entity0 had a median serum @entity4 level of 97 (55-123)  mol/L by the last visit. The median estimated glomerular filtration rate level was 85.4 (58-136) mL/min. Five episodes of biopsy-proven acute rejection occurred in 4 @entity0 , which were reversed by @entity8 pulse therapy. @entity9 was observed in 1 @entity0 , which was cured by interventional balloon dilatation and stent implantation. CONCLUSION: Pediatric s-DBCD is feasible with acceptable graft quality. Single kidney transplantation with pediatric graft size >7 cm has good clinical outcomes.

title: Chinese Pediatric Organ Donation With Scheduled Cardiac Arrest After XXXX : A Novel China Classification Beyond Maastricht.

answer: @entity7


abstract: BACKGROUND: Combined @entity3 ( @entity3 ) and light therapy (LT) cause a rapid improvement in @entity1 which has been hypothesized to be paralleled by changes in sleep homeostasis. Recent studies showed that @entity1 @entity0 had lower changes of EEG theta power after sleep and responders to antidepressant @entity3 +LT slept less and showed a lower increase of EEG theta power then non-responders. A polymorphism in @entity4 gene has been associated with diurnal preference, sleep structure and homeostatic response to sleep deprivation in healthy subjects. We hypothesized that the individual variability in the homeostatic response to @entity3 could be a correlate of antidepressant response and be influenced by genetic factors. METHODS: We administered three @entity3 +LT cycles to @entity1 @entity0 . Severity of @entity2 was rated on Hamilton Depression Rating Scale. Actigraphic recordings were performed in a group of @entity0 . RESULTS: @entity4 polymorphism influenced changes in total sleep time (F=2.24; p=0.024): while @entity5 ) and @entity4 (4/5) @entity0 showed a reduction in it after treatment, @entity4 (5/5) subjects showed an increase of about 40min, suggesting a higher homeostatic pressure. The same polymorphism influenced the change of depressive symptomatology during treatment (F=3.72; p=0.028). LIMITATIONS: Sleep information was recorded till the day after the end of treatment: a longer period of observation could give more information about the possible maintenance of allostatic adaptation. CONCLUSIONS: A higher sleep homeostatic pressure reduced the antidepressant response to @entity3 +LT, while an allostatic adaptation to sleep loss was associated with better response. This process seems to be under genetic control.

title: Sleep homeostatic pressure and @entity4 VNTR gene polymorphism influence antidepressant response to sleep XXXX .

answer: @entity1


abstract: BACKGROUND: Combined @entity3 ( @entity3 ) and light therapy (LT) cause a rapid improvement in @entity1 which has been hypothesized to be paralleled by changes in sleep homeostasis. Recent studies showed that @entity1 @entity0 had lower changes of EEG theta power after sleep and responders to antidepressant @entity3 +LT slept less and showed a lower increase of EEG theta power then non-responders. A polymorphism in @entity4 gene has been associated with diurnal preference, sleep structure and homeostatic response to sleep deprivation in healthy subjects. We hypothesized that the individual variability in the homeostatic response to @entity3 could be a correlate of antidepressant response and be influenced by genetic factors. METHODS: We administered three @entity3 +LT cycles to @entity1 @entity0 . Severity of @entity2 was rated on Hamilton Depression Rating Scale. Actigraphic recordings were performed in a group of @entity0 . RESULTS: @entity4 polymorphism influenced changes in total sleep time (F=2.24; p=0.024): while @entity5 ) and @entity4 (4/5) @entity0 showed a reduction in it after treatment, @entity4 (5/5) subjects showed an increase of about 40min, suggesting a higher homeostatic pressure. The same polymorphism influenced the change of depressive symptomatology during treatment (F=3.72; p=0.028). LIMITATIONS: Sleep information was recorded till the day after the end of treatment: a longer period of observation could give more information about the possible maintenance of allostatic adaptation. CONCLUSIONS: A higher sleep homeostatic pressure reduced the antidepressant response to @entity3 +LT, while an allostatic adaptation to sleep loss was associated with better response. This process seems to be under genetic control.

title: Sleep homeostatic pressure and XXXX VNTR gene polymorphism influence antidepressant response to sleep @entity1 .

answer: @entity4


abstract: BACKGROUND AND AIM: @entity10 is a major cause of @entity9 worldwide. We estimated the global prevalence, incidence, progression and outcomes of @entity10 and NASH. METHODS: Pubmed/MEDLINE were searched from 1989-2015 for terms involving epidemiology and progression of @entity10 . EXCLUSIONS: selected groups (only morbidly @entity2 or @entity1 or pediatric), no data on @entity7 consumption or other @entity9 . Incidence of @entity5 , @entity3 , overall mortality and liver-related mortality were determined. NASH required histologic criteria. All studies were reviewed by 3 independent investigators. Analysis was stratified by region, diagnostic technique, biopsy indication and study population. We used random-effects models to provide point estimates (95% CI) of prevalence, incidence, mortality and incidence rate ratios, and meta-regression with sub-group analysis to account for heterogeneity. RESULTS: Out of 729 studies, 86 were included with a sample size of 8,515,431 from 22 countries. Global prevalence of @entity10 is 25.24% (22.10-28.65) with highest prevalence in Middle East and South America and lowest in Africa. Metabolic comorbidities associated with @entity10 included @entity2 [51.34% (41.38-61.20)], type 2 @entity1 [22.51% (17.92-27.89)], @entity8 [69.16% (49.91-83.46%)], @entity4 [(39.34% (33.15-45.88)]] and @entity6 [42.54% (30.06-56.05)] . @entity3 progression proportion, measured in Brunt's score, and mean annual rate of progression in NASH were 40.76% (34.69-47.13) and 0.09 (0.06-0.12). @entity5 incidence among @entity10 @entity0 was 0.44/1000 @entity0 -years (0.29-0.66). Liver-specific mortality and overall mortality among @entity10 and NASH were 0.77/1000 @entity0 -years (0.33-1.77) and 11.77/1000 @entity0 -years (7.10-19.53), 15.44/1000 @entity0 -years (11.72-20.34) and 25.56/1000 @entity0 -years (6.29-103.80). Incidence Risk Ratios for liver-specific and overall mortality for @entity10 were 1.94 (1.28-2.92) and 1.05 (0.70-1.56). CONCLUSIONS: As the global epidemic of @entity2 fuels metabolic conditions, the clinical and economic burden of @entity10 will become enormous.f This article is protected by copyright. All rights reserved.

title: Global Epidemiology of Non-Alcoholic Fatty XXXX -Meta-Analytic Assessment of Prevalence, Incidence and Outcomes.

answer: @entity9


abstract: AIM: To evaluate the efficacy of early @entity2 therapy in stress urinary @entity1 occurring after radical prostatectomy (RP). MATERIAL AND METHOD: @entity0 that had RP were randomly divided into 2 groups following the removal of the urinary catheter. Group A @entity0 (n = 28) had pelvic floor exercise and @entity2 therapy. Group B @entity0 (n = 30) had only pelvic floor exercise. The @entity1 status of the @entity0 and number of pads were recorded and 1-hour pad test and Turkish validation of International Consultation on Incontinence Questionnaire-Short Form test were applied to the @entity0 at the follow-up. RESULTS: When the dry state of the @entity0 was evaluated, 5, 17, 3, and 2 of 28 Group A @entity0 stated that they were completely dry in the 3rd, 6th, 9th and 12th month respectively and pad use was stopped. There was no continence in 30 Group B in the first 3 months. Twelve, 6, and 8 @entity0 stated that they were completely dry in the 6th, 9th and 12th month, respectively. But 3 of 4 @entity0 in whom dryness could not be provided were using a mean of 7.6 pads in the first day and a mean of 1.3 pads after 1 year. When pad use of the @entity0 was evaluated, the mean monthly number of pad use was determined to be 6.2 (4-8) in the initial evaluation, 2.7 (0-5) in the in 3rd month, 2 (0-3) in the 6th month and 1.6 (0-2) pad/d in the 9th month in the group taking medicine. The mean monthly number of pads used was determined to be 5.8 (4-8) in the initial evaluation, 4.3 (3-8) in the 3rd month, 3 (0-6) in the 6th month and 1.6 (0-6) pad/d in the 9th month in the group not taking medicine. CONCLUSION: According to the results, early @entity2 therapy in stress urinary @entity1 that occurred after RP provided early continence.

title: Efficacy of XXXX in the Early Management of Urinary Continence after Radical Prostatectomy.

answer: @entity2


abstract: UNASSIGNED: @entity8 , including @entity4 and apoptotic death of retinal ganglion cells (RGCs), eventually leads to irreversible @entity3 . @entity5 (CO) acts as a therapeutic agent against @entity2 via its anti-apoptotic effect. Here we hypothesized that low-dose CO inhalation can protect RGCs in a @entity1 model of optic nerve crush (ONC). ONC was performed on adult male @entity1 to imitate glaucomatous @entity0 . Low-dose CO (250  ppm) or air was inhaled for 1  h immediately after ONC, and all the tests were carried out 2 weeks later. Flash visual evoked potentials (FVEP) and pupil light relax (PLR) were recorded for the assessment of visual function. RGC density was evaluated by @entity6 and @entity7 staining and Fluorogold labeling. Retinal apoptotic process was assessed by TUNEL staining and @entity9 activity measurement. Low-dose CO treatment significantly ameliorated the abnormalities of FVEP and PLR induced by ONC. As expected, the RGC density was increased remarkably by CO inhalation after the glaucomatous @entity8 . Moreover, CO treatment after ONC significantly decreased the number of TUNEL-positive cells in ganglion cell layer and attenuated the retinal @entity9 activity. Low-dose CO inhalation protects RGCs from @entity10 via inhibiting @entity9 dependent apoptosis.

title: Low-dose XXXX inhalation protects neuronal cells from apoptosis after optic nerve crush.

answer: @entity5


abstract: UNASSIGNED: Pregnancy is a time of marked neural, physiological and behavioral plasticity in the female and is often a time when @entity0 are more vulnerable to stress and stress-related diseases, such as @entity3 and @entity2 . Unfortunately the impact of stress during gestation on neurobiological processes of the mother has yet to be fully determined, particularly with regard to changes in the hippocampus; a brain area that plays an important role in stress-related diseases. The present study aimed to determine how stress early in pregnancy may affect hippocampal plasticity in the pregnant female and whether these effects differ from those in virgin females. For this purpose, adult age-matched pregnant and virgin female @entity1 were divided into two conditions: (1) Control and (2) Stress. Females in the stress condition were restrained during days 5-11 of gestation and at matched time-points in virgin females. All pregnant females received an injection of @entity6 ( @entity6 ) on day 1 of gestation and were sacrificed 21days later. The same procedure was carried out at matched time points in virgin females. Results show that for number of Ki67-immunoreactive (ir) cells and doublecortin ( @entity7 )-ir cells, there were significant interactions between reproductive state (pregnant/virgin) and stress exposure (p=.05, p=.04, respectively) with control virgin and stressed pregnant females having more Ki67-ir cells than control pregnant females and more @entity7 -ir cells than stressed virgin females. Results also show that pregnant females had significantly greater glucocorticoid receptor (GR) density in the @entity4 , @entity5 and granule cell layer compared to virgin females. In addition, there was a main effect of stress on GR density in the @entity5 region, with stressed females having significantly lower GR density compared to control females (p=.01). This work adds to our understanding of how stress and reproductive state affect plasticity in the female hippocampus.

title: Effects of stress early in gestation on hippocampal neurogenesis and glucocorticoid receptor density in pregnant XXXX .

answer: @entity1


abstract: PURPOSE: The effect of anastomotic urethroplasty for pelvic fracture @entity1 (PFUIs) on ejaculatory profile is under-reported in the literature. There is controversy as regards the effect of bulbocavernous muscle splitting during surgery on ejaculatory function (EjF). We evaluated the effects of anastomotic urethroplasty on EjF using a validated questionnaire. METHODS: We retrospectively reviewed the computerized surgical records to identify @entity0 who underwent anastomotic posterior urethroplasty for PFUIs from June 1998 to January 2014. Those @entity0 were retrieved and evaluated for their EjF using the EjF component of the Male Sexual Health Questionnaire (MSHQ). RESULTS: Overall, 58 @entity0 were included in the study with a mean age of 31.6  years. All @entity0 except one have antegrade ejaculation, and according to the overall ejaculatory score, only 5 @entity0 (8.6  %) reported @entity2 and the remaining 53 (91.4  %) had good or average EjF. Ten @entity0 (17.2  %) reported decreased volume and force of ejaculate. Decreased pleasure during ejaculation was the commonest ejaculatory disorder (39.6  %). The score of each of the seven ejaculatory questions among the study @entity0 was in harmony to the previous study of anterior urethroplasty except that @entity0 in this study had higher ejaculatory frequency and latency. CONCLUSIONS: Nearly all @entity0 maintained antegrade ejaculation after posterior urethroplasty for PFUIs. The risk of urethral reconstruction and splitting the bulbocavernous muscle on ejaculation seems to be minimal.

title: Ejaculatory function after anastomotic urethroplasty for pelvic fracture XXXX .

answer: @entity1


abstract: AIM: The relationship between @entity1 @entity3 factor-alpha ( @entity4 ) and drug survival had not been studied in @entity5 ( @entity5 ) and there were no laboratory tests to predict the long-term efficacy of biological drugs for @entity5 . We studied if serum levels of @entity4 , free or bound to etanercept, could predict long-term efficacy of etanercept in @entity0 with @entity5 . METHODS: We included 41 biologic-na  ve @entity0 with @entity5 who started treatment with etanercept at Sk  ne University Hospital between 1999-2010. Serum taken at the start of treatment and at the six-week follow up were analysed for @entity4 and the long-term efficacy of etanercept was assessed using the drug survival time. RESULTS: Levels of @entity4 increased significantly at the six-week follow up and this was almost exclusively comprised of @entity4 in complex with etanercept. The increase in @entity4 showed a dose-dependent correlation to long-term drug survival (p < 0.01). CONCLUSION: Increasing levels of circulating @entity4 at treatment initiation predicted long-term efficacy of etanercept in @entity0 with @entity5 , which may have been due to different pathophysiological mechanisms of @entity2 . Our result may provide a helpful clinical tool, as high levels of circulating @entity4 /etanercept-complexes could be used as a marker for the long-term efficacy of etanercept. This article is protected by copyright. All rights reserved.

title: Circulating complexes between XXXX @entity3 factor-alpha and etanercept predict long-term efficacy of etanercept in @entity5 .

answer: @entity1


abstract: AIM: The relationship between @entity1 @entity3 factor-alpha ( @entity4 ) and drug survival had not been studied in @entity5 ( @entity5 ) and there were no laboratory tests to predict the long-term efficacy of biological drugs for @entity5 . We studied if serum levels of @entity4 , free or bound to etanercept, could predict long-term efficacy of etanercept in @entity0 with @entity5 . METHODS: We included 41 biologic-na  ve @entity0 with @entity5 who started treatment with etanercept at Sk  ne University Hospital between 1999-2010. Serum taken at the start of treatment and at the six-week follow up were analysed for @entity4 and the long-term efficacy of etanercept was assessed using the drug survival time. RESULTS: Levels of @entity4 increased significantly at the six-week follow up and this was almost exclusively comprised of @entity4 in complex with etanercept. The increase in @entity4 showed a dose-dependent correlation to long-term drug survival (p < 0.01). CONCLUSION: Increasing levels of circulating @entity4 at treatment initiation predicted long-term efficacy of etanercept in @entity0 with @entity5 , which may have been due to different pathophysiological mechanisms of @entity2 . Our result may provide a helpful clinical tool, as high levels of circulating @entity4 /etanercept-complexes could be used as a marker for the long-term efficacy of etanercept. This article is protected by copyright. All rights reserved.

title: Circulating complexes between @entity1 @entity3 factor-alpha and etanercept predict long-term efficacy of etanercept in XXXX .

answer: @entity5


abstract: AIM: The relationship between @entity1 @entity3 factor-alpha ( @entity4 ) and drug survival had not been studied in @entity5 ( @entity5 ) and there were no laboratory tests to predict the long-term efficacy of biological drugs for @entity5 . We studied if serum levels of @entity4 , free or bound to etanercept, could predict long-term efficacy of etanercept in @entity0 with @entity5 . METHODS: We included 41 biologic-na  ve @entity0 with @entity5 who started treatment with etanercept at Sk  ne University Hospital between 1999-2010. Serum taken at the start of treatment and at the six-week follow up were analysed for @entity4 and the long-term efficacy of etanercept was assessed using the drug survival time. RESULTS: Levels of @entity4 increased significantly at the six-week follow up and this was almost exclusively comprised of @entity4 in complex with etanercept. The increase in @entity4 showed a dose-dependent correlation to long-term drug survival (p < 0.01). CONCLUSION: Increasing levels of circulating @entity4 at treatment initiation predicted long-term efficacy of etanercept in @entity0 with @entity5 , which may have been due to different pathophysiological mechanisms of @entity2 . Our result may provide a helpful clinical tool, as high levels of circulating @entity4 /etanercept-complexes could be used as a marker for the long-term efficacy of etanercept. This article is protected by copyright. All rights reserved.

title: Circulating complexes between @entity1 XXXX factor-alpha and etanercept predict long-term efficacy of etanercept in @entity5 .

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to find out if Twitter could be used in a research context as a ubiquitous piece of software to record daily @entity1 . DESIGN: This study was a feasibility study conducted electronically. SETTING: Our research was conducted on Twitter in 2014. SUBJECTS AND METHODS: @entity0 were recruited via electronic advertising and consented electronically to participate. At three time-points on two non-sequential days @entity0 were asked to record @entity1 , mood and impact ratings on a numerical scale (0-10). Data were extracted manually. RESULTS: Thirty-five individuals consented to participate. Of the 24 @entity0 providing data, 16 provided enough data to be analysed. The majority of @entity0 were female. The mean age was 44.9 (   0.78) years and the most common diagnosis for @entity0 was @entity2 . @entity0 lived in the UK, USA, Canada and New Zealand. An increase in mean @entity1 was reported over consecutive time periods on both days while mood and impact patterns varied between days. CONCLUSION: Our study highlighted that @entity0 can be recruited solely via social media and has ascertained the ease in which data can be collected without technical expertise. To achieve greater participation, differing advertisement strategies should be explored.

title: Twitter: a viable medium for daily XXXX diaries in chronic @entity1 ?

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to find out if Twitter could be used in a research context as a ubiquitous piece of software to record daily @entity1 . DESIGN: This study was a feasibility study conducted electronically. SETTING: Our research was conducted on Twitter in 2014. SUBJECTS AND METHODS: @entity0 were recruited via electronic advertising and consented electronically to participate. At three time-points on two non-sequential days @entity0 were asked to record @entity1 , mood and impact ratings on a numerical scale (0-10). Data were extracted manually. RESULTS: Thirty-five individuals consented to participate. Of the 24 @entity0 providing data, 16 provided enough data to be analysed. The majority of @entity0 were female. The mean age was 44.9 (   0.78) years and the most common diagnosis for @entity0 was @entity2 . @entity0 lived in the UK, USA, Canada and New Zealand. An increase in mean @entity1 was reported over consecutive time periods on both days while mood and impact patterns varied between days. CONCLUSION: Our study highlighted that @entity0 can be recruited solely via social media and has ascertained the ease in which data can be collected without technical expertise. To achieve greater participation, differing advertisement strategies should be explored.

title: Twitter: a viable medium for daily @entity1 diaries in chronic XXXX ?

answer: @entity1


abstract: Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunosuppressive properties. They have emerged as a very promising treatment for @entity7 and @entity2 such as @entity3 . Recent data have identified that @entity8 -expressing CD4   T cells and Th17 cells have critical roles in the pathogenesis of @entity5 and other @entity2 . Although many studies have demonstrated that MSCs can either prevent or suppress @entity2 , no studies have addressed their modulation on @entity8 -expressing CD4   T cells and on the plasticity of Th17 cells. To address this, a single dose of @entity0 expanded adipose-derived mesenchymal stem cells (eASCs) was administered to @entity1 with established collagen-induced @entity5 . A beneficial effect was observed soon after the infusion of the eASCs as shown by a significant decrease in the severity of @entity5 . This was accompanied by reduced number of pathogenic @entity8 (+) CD4(+) T cells in the spleen and peripheral blood and by an increase in the number of different subsets of regulatory T cells like @entity4 (+) CD4(+) T cells and @entity6 (+) @entity9 (-) CD4(+) T cells in the draining lymph nodes (LNs). Interestingly, increased numbers of Th17 cells coexpressing @entity6 were also found in draining LNs. These results demonstrate that eASCs ameliorated @entity5 after the onset of the disease by reducing the total number of pathogenic @entity8 (+) CD4(+) T and by increasing the number of different subsets of regulatory T cells in draining LNs, including Th17 cells expressing @entity6 . All these cellular responses, ultimately, lead to the reestablishment of the regulatory/inflammatory balance in the draining LNs.

title: @entity0 Adipose-Derived Mesenchymal Stem Cells Modulate Experimental Autoimmune XXXX by Modifying Early Adaptive T Cell Responses.

answer: @entity5


abstract: Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunosuppressive properties. They have emerged as a very promising treatment for @entity7 and @entity2 such as @entity3 . Recent data have identified that @entity8 -expressing CD4   T cells and Th17 cells have critical roles in the pathogenesis of @entity5 and other @entity2 . Although many studies have demonstrated that MSCs can either prevent or suppress @entity2 , no studies have addressed their modulation on @entity8 -expressing CD4   T cells and on the plasticity of Th17 cells. To address this, a single dose of @entity0 expanded adipose-derived mesenchymal stem cells (eASCs) was administered to @entity1 with established collagen-induced @entity5 . A beneficial effect was observed soon after the infusion of the eASCs as shown by a significant decrease in the severity of @entity5 . This was accompanied by reduced number of pathogenic @entity8 (+) CD4(+) T cells in the spleen and peripheral blood and by an increase in the number of different subsets of regulatory T cells like @entity4 (+) CD4(+) T cells and @entity6 (+) @entity9 (-) CD4(+) T cells in the draining lymph nodes (LNs). Interestingly, increased numbers of Th17 cells coexpressing @entity6 were also found in draining LNs. These results demonstrate that eASCs ameliorated @entity5 after the onset of the disease by reducing the total number of pathogenic @entity8 (+) CD4(+) T and by increasing the number of different subsets of regulatory T cells in draining LNs, including Th17 cells expressing @entity6 . All these cellular responses, ultimately, lead to the reestablishment of the regulatory/inflammatory balance in the draining LNs.

title: XXXX Adipose-Derived Mesenchymal Stem Cells Modulate Experimental Autoimmune @entity5 by Modifying Early Adaptive T Cell Responses.

answer: @entity0


abstract: BACKGROUND: For mild-to-moderate @entity1 survivors, early supported discharge from hospital, followed by home rehabilitation is preferred over conventional care. How this mode of service contributes to recovery from @entity1 survivors' perspective needs further investigation. AIM: The aim of this study was to explore mild-to-moderate @entity1 survivors' experiences with home rehabilitation after early supported discharge from hospital. METHODS: A qualitative interpretive interview design was used in the context of a randomised controlled trial. A purposive sample of eight @entity0 (45-80  years) was followed by an ambulant team, and a specific healthcare team provided home rehabilitation. Data were analysed using interpretive description, systematic text condensation and coping theory. FINDINGS: A crucial determinant for the @entity0 ' hopes for a life worth living was the mutual confidence expressed in encounters with healthcare professionals and the @entity0 ' ability to make sense of their now-altered body. The professional caretakers' communication qualities and their ability to attend to individual needs were important. Help in processing the emotional reactions caused by a changed body and in socialising was requested by @entity0 . Professional caretakers providing home rehabilitation should strive for a more flexible- and individually tailored service and should seek increased cooperation among stakeholders. CONCLUSION: The focus on therapeutic communicative qualities, bodily changes, emotional processes, social concerns and long-term follow-up should be increased in order to achieve a more beneficial experience for @entity1 survivors.

title: Striving for a life worth living: XXXX survivors' experiences of home rehabilitation.

answer: @entity1


abstract: PURPOSE: This 2-arm crossover study compared the relative bioavailability of two @entity9 ( @entity9 ) formulations [anhydrate clinical service form (CSF) capsule and monohydrate final market image (FMI) tablet; @entity6 ] and determined the effect of food on @entity9 exposure ( @entity7 ). METHODS: @entity1 with advanced solid @entity2 , excluding @entity0 , were enrolled in 1 of the 2 arms of the study. @entity1 in @entity6 were randomized to a single 500-mg dose of CSF capsule or FMI tablet followed by 7  days of rest and 500  mg of the other formulation. @entity1 in @entity7 received 300  mg of FMI tablet daily and were randomized to follow 1 of 6 meal sequences, each with 3 prandial conditions: low fat (LF), high fat (HF), or no meal (NM). RESULTS: In @entity6 (n  =  21), 17 @entity1 were evaluable. FMI tablet compared with CSF capsule showed only slight reductions in the adjusted geometric means for area under the plasma concentration-time curve (AUClast; 3  %) and maximum plasma concentration (C max; 1  %). In @entity7 (n  =  42), 19 @entity1 were evaluable. HF meal versus NM showed a 9  % decrease in the adjusted geometric mean for AUClast and an 18  % decrease for C max. Comparison of LF meal versus NM showed a 1  % decrease for AUClast and a 10  % decrease for C max. Common adverse events suspected to be study drug related included @entity5 , @entity3 , @entity4 , and @entity8 . CONCLUSIONS: @entity9 FMI tablet had similar systemic exposure to the CSF capsule and was not affected by food.

title: A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of XXXX ( @entity9 ).

answer: @entity9


abstract: PURPOSE: This 2-arm crossover study compared the relative bioavailability of two @entity9 ( @entity9 ) formulations [anhydrate clinical service form (CSF) capsule and monohydrate final market image (FMI) tablet; @entity6 ] and determined the effect of food on @entity9 exposure ( @entity7 ). METHODS: @entity1 with advanced solid @entity2 , excluding @entity0 , were enrolled in 1 of the 2 arms of the study. @entity1 in @entity6 were randomized to a single 500-mg dose of CSF capsule or FMI tablet followed by 7  days of rest and 500  mg of the other formulation. @entity1 in @entity7 received 300  mg of FMI tablet daily and were randomized to follow 1 of 6 meal sequences, each with 3 prandial conditions: low fat (LF), high fat (HF), or no meal (NM). RESULTS: In @entity6 (n  =  21), 17 @entity1 were evaluable. FMI tablet compared with CSF capsule showed only slight reductions in the adjusted geometric means for area under the plasma concentration-time curve (AUClast; 3  %) and maximum plasma concentration (C max; 1  %). In @entity7 (n  =  42), 19 @entity1 were evaluable. HF meal versus NM showed a 9  % decrease in the adjusted geometric mean for AUClast and an 18  % decrease for C max. Comparison of LF meal versus NM showed a 1  % decrease for AUClast and a 10  % decrease for C max. Common adverse events suspected to be study drug related included @entity5 , @entity3 , @entity4 , and @entity8 . CONCLUSIONS: @entity9 FMI tablet had similar systemic exposure to the CSF capsule and was not affected by food.

title: A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of @entity9 ( XXXX ).

answer: @entity9


abstract: UNASSIGNED: @entity6 ( @entity6 ) is a multifunctional kinase whose inhibition is known to limit @entity4 -reperfusion injury. However, the mechanism mediating this beneficial effect still remains unclear. Mitochondria and sarco/endoplasmic reticulum (SR/ER) are key players in cell death signaling. Their involvement in @entity4 -reperfusion injury has gained recognition recently, but the underlying mechanisms are not yet well understood. We questioned here whether @entity6 might have a role in the @entity1 transfer from SR/ER to mitochondria at reperfusion. We showed that a fraction of @entity6 protein is localized to the SR/ER and mitochondria-associated ER membranes (MAMs) in the heart, and that @entity6 specifically interacted with the @entity3 receptors (IP3Rs) @entity1 channeling complex in MAMs. We demonstrated that both pharmacological and genetic inhibition of @entity6 decreased protein interaction of @entity5 with the @entity1 channeling complex, impaired SR/ER @entity1 release and reduced the @entity0 -stimulated @entity1 exchange between SR/ER and mitochondria in cardiomyocytes. During @entity2 reoxygenation, cell death is associated with an increase of @entity6 activity and @entity5 phosphorylation, which leads to enhanced transfer of @entity1 from SR/ER to mitochondria. Inhibition of @entity6 at reperfusion reduced both @entity5 phosphorylation and SR/ER @entity1 release, which consequently diminished both cytosolic and mitochondrial @entity1 concentrations, as well as sensitivity to apoptosis. We conclude that inhibition of @entity6 at reperfusion diminishes @entity1 leak from @entity5 at MAMs in the heart, which limits both cytosolic and mitochondrial @entity1 overload and subsequent cell death.

title: The SR/ER-mitochondria calcium crosstalk is regulated by XXXX during reperfusion injury.

answer: @entity6


abstract: OBJECTIVE: Non-steroidal anti-inflammatory drug (NSAID) use has been linked to a reduction in the risk of several @entity1 types. For @entity3 , however, results have been inconsistent. To summarize the available evidence on the risk of @entity3 associated with use of @entity2 or non- @entity2 (NA-) NSAIDs, we performed a systematic review and meta-analysis of observational studies. METHODS: We conducted a bibliographic database search in PubMed, Embase and Cochrane Library. Relative risk estimates were extracted from eligible case-control and cohort studies and pooled using a random effects model. RESULTS: Six case-control and seven cohort studies were found eligible for our meta-analysis. We observed risk reductions in @entity3 associated with regular use of @entity2 (case-control: 11%, cohort: 8%) and NA-NSAIDs (case-control: 9%, cohort: 6%), compared to non-use. However, the pooled risk ratios were not statistically significant. Higher risk reductions were seen with high frequency of notably @entity2 use (case-control: 37%, cohort: 20%). The inverse association between regular @entity2 use and @entity3 risk was strongest among @entity0 with a body mass index above 30 (case-control: 44%, cohort: 20%). CONCLUSIONS: Regular use of @entity2 or NA-NSAIDs was associated with a marginally reduced risk of @entity3 . Larger risk reductions were linked with high frequency of NSAID use and high BMI.

title: Non-steroidal anti-inflammatory drug use and risk of XXXX : A systematic review and meta-analysis of observational studies.

answer: @entity3


abstract: BACKGROUND: Rectourethral @entity2 is a challenging complication of radical retropubic prostatectomy. Several treatments have been proposed, with varying outcomes. The available data are difficult to interpret, because @entity0 and disease characteristics differ significantly among reports. Details of long-term follow-up and functional status are rarely provided. We describe a technique of @entity2 repair via an intersphincteric route. METHODS: Preoperative workup included proctoscopy and urethrocystography. All @entity0 already had a stoma at the time of @entity2 repair. Mechanical cleansing of the bowel distal to the colostomy was routinely performed, and perioperative antibiotic prophylaxis was administered. @entity0 were placed in the lithotomy position. Under spinal anesthesia, a curvilinear anteanal incision was made, to expose the external sphincter. The anterior portion of the external sphincter was gently displaced along half of its circumference. The anterior rectal wall was sharply dissected free from the urethra, approximately up to 2 cm above the @entity2 level through the intersphincteric plane. The @entity2 was identified. The surrounding tissues were mobilized to obtain a tension-free repair of the @entity4 , using a single row of 4-0 polyglactin transverse, interrupted sutures. Transanally, a U-shaped full-thickness rectal flap was advanced and sutured with 3-0 monofilament interrupted sutures to cover the rectal opening, and care was taken to ensure that the two suture lines were in different planes. The catheter was left in place for 4 weeks. @entity0 were evaluated at 3-month follow-up for stoma closure. RESULTS: We successfully treated five @entity0 . Only one minor complication was observed ( @entity1 ). Stomas were taken down uneventfully. After a median follow-up duration of 2 years (range 2-3 years), no @entity0 had @entity2 recurrence or impaired continence. CONCLUSIONS: Intersphincteric repair should be considered as an effective option in @entity0 with @entity3 . This technique offers several advantages over alternative procedures that require more extensive approaches or invasive manipulation of the anal sphincters.

title: Intersphincteric approach for XXXX following radical prostatectomy.

answer: @entity2


abstract: INTRODUCTION AND OBJECTIVES: Initial preclinical studies are required during the process of improving polymers, platforms, and drug-eluting systems for new coronary stent designs. Our objective was to analyze the efficacy and safety of new drug-eluting stent models compared with a conventional stent and commercialized drug-eluting stents in an experimental model with healthy porcine coronary arteries. METHODS: Sixty stents (conventional stent, new @entity2 -eluting stents: drug-eluting stents 1, 2 and 3; Cypher(  ) and Xience(  )) were randomly placed in the coronary arteries of 20 Large White @entity3 . Angiographic and histomorphometric studies were done 28 days later. RESULTS: The stents were implanted at a stent/artery ratio of 1.34  0.15, with no significant differences between groups. The new stents showed less late loss and angiographic @entity1 than conventional stents (P=.006 and P<.001, respectively). Histologically, @entity1 and neointimal area were lower with all the new platforms than with the conventional stents (P<.001 for each variable), and no differences were found vs the drug-eluting stents on the market. Safety data showed that endothelialization was lower with drug-eluting stents than with conventional stents, except for drug-eluting stent 3 (P=.084). Likewise, @entity0 was lower with drug-eluting stent 3 than with other stents. CONCLUSIONS: The new drug-eluting stent platforms studied are associated with less @entity1 than conventional stents and showed no significant differences in safety or efficacy vs commercialized drug-eluting stents.

title: Safety and Efficacy of New XXXX -eluting Stent Models in a Preclinical Study.

answer: @entity2


abstract: UNASSIGNED: Black raspberries (BRB) demonstrate potent inhibition of aerodigestive tract @entity2 in animal models. However, translational clinical trials evaluating the ability of BRB phytochemicals to impact molecular biomarkers in the oral mucosa remain limited. The present phase 0 study addresses a fundamental question for @entity1 food-based prevention: Do BRB phytochemicals successfully reach the targeted oral tissues and reduce proinflammatory and antiapoptotic gene expression profiles? @entity0 with biopsy-confirmed @entity6 ( @entity6 ) administered oral troches containing freeze-dried BRB powder from the time of enrollment to the date of curative intent surgery (13.9    1.27 days). Transcriptional biomarkers were evaluated in @entity0 -matched OSCCs and noninvolved high at-risk mucosa (HARM) for BRB-associated changes. Significant expression differences between baseline @entity6 and HARM tissues were confirmed using a panel of genes commonly deregulated during oral @entity2 . Following BRB troche administration, the expression of prosurvival genes ( @entity5 , @entity9 , @entity4 ) and proinflammatory genes ( @entity7 , @entity8 ) were significantly reduced. There were no BRB-associated grade 3-4 @entity3 or adverse events, and 79.2% (N = 30) of @entity0 successfully completed the study with high levels of compliance (97.2%). The BRB phytochemicals @entity10 and @entity11 were detected in all @entity6 tissues analyzed, demonstrating that bioactive components were successfully reaching targeted @entity6 tissues. We confirmed that hallmark antiapoptotic and proinflammatory molecular biomarkers were overexpressed in OSCCs and that their gene expression was significantly reduced following BRB troche administration. As these molecular biomarkers are fundamental to oral @entity2 and are modifiable, they may represent emerging biomarkers of molecular efficacy for BRB-mediated @entity1 chemoprevention. Cancer Prev Res; 9(2); 1-13.   2015 AACR.

title: Suppression of Proinflammatory and Prosurvival Biomarkers in XXXX @entity0 Consuming a Black Raspberry Phytochemical-Rich Troche.

answer: @entity1


abstract: UNASSIGNED: Black raspberries (BRB) demonstrate potent inhibition of aerodigestive tract @entity2 in animal models. However, translational clinical trials evaluating the ability of BRB phytochemicals to impact molecular biomarkers in the oral mucosa remain limited. The present phase 0 study addresses a fundamental question for @entity1 food-based prevention: Do BRB phytochemicals successfully reach the targeted oral tissues and reduce proinflammatory and antiapoptotic gene expression profiles? @entity0 with biopsy-confirmed @entity6 ( @entity6 ) administered oral troches containing freeze-dried BRB powder from the time of enrollment to the date of curative intent surgery (13.9    1.27 days). Transcriptional biomarkers were evaluated in @entity0 -matched OSCCs and noninvolved high at-risk mucosa (HARM) for BRB-associated changes. Significant expression differences between baseline @entity6 and HARM tissues were confirmed using a panel of genes commonly deregulated during oral @entity2 . Following BRB troche administration, the expression of prosurvival genes ( @entity5 , @entity9 , @entity4 ) and proinflammatory genes ( @entity7 , @entity8 ) were significantly reduced. There were no BRB-associated grade 3-4 @entity3 or adverse events, and 79.2% (N = 30) of @entity0 successfully completed the study with high levels of compliance (97.2%). The BRB phytochemicals @entity10 and @entity11 were detected in all @entity6 tissues analyzed, demonstrating that bioactive components were successfully reaching targeted @entity6 tissues. We confirmed that hallmark antiapoptotic and proinflammatory molecular biomarkers were overexpressed in OSCCs and that their gene expression was significantly reduced following BRB troche administration. As these molecular biomarkers are fundamental to oral @entity2 and are modifiable, they may represent emerging biomarkers of molecular efficacy for BRB-mediated @entity1 chemoprevention. Cancer Prev Res; 9(2); 1-13.   2015 AACR.

title: Suppression of Proinflammatory and Prosurvival Biomarkers in @entity1 XXXX Consuming a Black Raspberry Phytochemical-Rich Troche.

answer: @entity0


abstract: The level of atmospheric @entity4 , a driver of free @entity3 and tumorigenesis, decreases sharply with rising elevation. To understand whether ambient @entity4 plays a role in @entity0 @entity5 , we characterized age-adjusted @entity2 incidence (compiled by the National @entity2 Institute from 2005 to 2009) across counties of the elevation-varying Western United States and compared trends displayed by @entity2 (lung) and @entity2 (breast, colorectal, and prostate). To adjust for important demographic and @entity2 -risk factors, 8-12 covariates were considered for each @entity2 . We produced regression models that captured known risks. Models demonstrated that elevation is strongly, negatively associated with @entity1 incidence (p < 10(-16)), but not with the incidence of @entity2 . For every 1,000 m rise in elevation, @entity1 incidence decreased by 7.23 99% CI [5.18-9.29] cases per 100,000 individuals, equivalent to 12.7% of the mean incidence, 56.8. As a predictor of @entity1 incidence, elevation was second only to smoking prevalence in terms of significance and effect size. Furthermore, no evidence of ecological fallacy or of confounding arising from evaluated factors was detected: the @entity1 association was robust to varying regression models, county stratification, and population subgrouping; additionally seven environmental correlates of elevation, such as exposure to sunlight and fine particulate matter, could not capture the association. Overall, our findings suggest the presence of an inhaled carcinogen inherently and inversely tied to elevation, offering epidemiological support for @entity4 -driven tumorigenesis. Finally, highlighting the need to consider elevation in studies of @entity1 , we demonstrated that previously reported inverse @entity1 associations with radon and UVB became insignificant after accounting for elevation.

title: @entity1 incidence decreases with elevation: evidence for XXXX as an inhaled carcinogen.

answer: @entity4


abstract: The level of atmospheric @entity4 , a driver of free @entity3 and tumorigenesis, decreases sharply with rising elevation. To understand whether ambient @entity4 plays a role in @entity0 @entity5 , we characterized age-adjusted @entity2 incidence (compiled by the National @entity2 Institute from 2005 to 2009) across counties of the elevation-varying Western United States and compared trends displayed by @entity2 (lung) and @entity2 (breast, colorectal, and prostate). To adjust for important demographic and @entity2 -risk factors, 8-12 covariates were considered for each @entity2 . We produced regression models that captured known risks. Models demonstrated that elevation is strongly, negatively associated with @entity1 incidence (p < 10(-16)), but not with the incidence of @entity2 . For every 1,000 m rise in elevation, @entity1 incidence decreased by 7.23 99% CI [5.18-9.29] cases per 100,000 individuals, equivalent to 12.7% of the mean incidence, 56.8. As a predictor of @entity1 incidence, elevation was second only to smoking prevalence in terms of significance and effect size. Furthermore, no evidence of ecological fallacy or of confounding arising from evaluated factors was detected: the @entity1 association was robust to varying regression models, county stratification, and population subgrouping; additionally seven environmental correlates of elevation, such as exposure to sunlight and fine particulate matter, could not capture the association. Overall, our findings suggest the presence of an inhaled carcinogen inherently and inversely tied to elevation, offering epidemiological support for @entity4 -driven tumorigenesis. Finally, highlighting the need to consider elevation in studies of @entity1 , we demonstrated that previously reported inverse @entity1 associations with radon and UVB became insignificant after accounting for elevation.

title: XXXX incidence decreases with elevation: evidence for @entity4 as an inhaled carcinogen.

answer: @entity1


abstract: INTRODUCTION: a @entity11 is one of the most common @entity3 of the digestive tract. The reported lifetime complication rate is 4%, mostly due to @entity7 , obstruction, perforation or @entity1 . A symptomatic @entity11 due to @entity5 after blunt @entity9 is very rare. We believe this case report is the first reporting a @entity5 of a @entity11 after a low velocity blunt @entity9 and outlining the importance of a thorough and complete examination of the @entity0 after blunt @entity9 . PRESENTATION OF CASE: a 17-year-old male presented with @entity6 after blunt @entity9 during a soccer game. Physical examination showed signs of @entity4 in all quadrants of the abdomen. During admission the @entity0 deteriorated with decreasing blood pressure and raising pulse rate. A CT-scan showed free abdominal fluid. Our @entity0 was scheduled for an emergent laparotomy where a perforated @entity11 with fecal spill was found. A segmental ileal resection was performed. Post-operative, @entity0 developed a @entity2 and @entity10 treated with percutaneous drainage. After an admission period of 17-days the @entity0 was discharged. CONCLUSION: perforation of a @entity11 is rarely suspected as a cause of @entity8 following blunt @entity9 . This case shows the importance of awareness of this kind of injury especially in male @entity0 .

title: @entity5 of a @entity11 due to blunt XXXX in a soccer game: A case report.

answer: @entity9


abstract: INTRODUCTION: a @entity11 is one of the most common @entity3 of the digestive tract. The reported lifetime complication rate is 4%, mostly due to @entity7 , obstruction, perforation or @entity1 . A symptomatic @entity11 due to @entity5 after blunt @entity9 is very rare. We believe this case report is the first reporting a @entity5 of a @entity11 after a low velocity blunt @entity9 and outlining the importance of a thorough and complete examination of the @entity0 after blunt @entity9 . PRESENTATION OF CASE: a 17-year-old male presented with @entity6 after blunt @entity9 during a soccer game. Physical examination showed signs of @entity4 in all quadrants of the abdomen. During admission the @entity0 deteriorated with decreasing blood pressure and raising pulse rate. A CT-scan showed free abdominal fluid. Our @entity0 was scheduled for an emergent laparotomy where a perforated @entity11 with fecal spill was found. A segmental ileal resection was performed. Post-operative, @entity0 developed a @entity2 and @entity10 treated with percutaneous drainage. After an admission period of 17-days the @entity0 was discharged. CONCLUSION: perforation of a @entity11 is rarely suspected as a cause of @entity8 following blunt @entity9 . This case shows the importance of awareness of this kind of injury especially in male @entity0 .

title: XXXX of a @entity11 due to blunt @entity9 in a soccer game: A case report.

answer: @entity5


abstract: INTRODUCTION: a @entity11 is one of the most common @entity3 of the digestive tract. The reported lifetime complication rate is 4%, mostly due to @entity7 , obstruction, perforation or @entity1 . A symptomatic @entity11 due to @entity5 after blunt @entity9 is very rare. We believe this case report is the first reporting a @entity5 of a @entity11 after a low velocity blunt @entity9 and outlining the importance of a thorough and complete examination of the @entity0 after blunt @entity9 . PRESENTATION OF CASE: a 17-year-old male presented with @entity6 after blunt @entity9 during a soccer game. Physical examination showed signs of @entity4 in all quadrants of the abdomen. During admission the @entity0 deteriorated with decreasing blood pressure and raising pulse rate. A CT-scan showed free abdominal fluid. Our @entity0 was scheduled for an emergent laparotomy where a perforated @entity11 with fecal spill was found. A segmental ileal resection was performed. Post-operative, @entity0 developed a @entity2 and @entity10 treated with percutaneous drainage. After an admission period of 17-days the @entity0 was discharged. CONCLUSION: perforation of a @entity11 is rarely suspected as a cause of @entity8 following blunt @entity9 . This case shows the importance of awareness of this kind of injury especially in male @entity0 .

title: @entity5 of a XXXX due to blunt @entity9 in a soccer game: A case report.

answer: @entity11


abstract: OBJECTIVES: Endoscopic resection (ER) is becoming an increasingly used treatment option for early @entity1 (EGC); however, data comparing the long-term outcomes of ER and surgery are limited. Accordingly, we here aimed to perform a meta-analysis to clarify the long-term outcomes and safety of ER and surgery for EGC. METHODS: Literature on the direct comparison of ER and surgery for EGC was retrieved from the Medline, PubMed and Scopus databases. We selected the eligible studies, extracted data, and assessed the quality scores according to the guidelines. The overall survival (OS), @entity2 ( @entity2 ), and adverse event rates were investigated, and the pooled hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI) were estimated. RESULTS: Nine retrospective studies were identified, including 973 and 1190 @entity0 undergoing ER and surgery, respectively. There were no significant differences regarding the OS (HR: 0.995, 95% CI: 0.836-1.185; p=0.959) and adverse event rates (OR: 0.50, 95% CI: 0.20-1.28, p=0.148) between ER and gastrectomy. However, @entity0 undergoing ER had significantly shorter @entity2 (HR: 7.226, 95% CI: 1.718-30.400, p=0.007) than those undergoing gastrectomy. CONCLUSIONS: Despite the limitations of this review, including the retrospective nature of all included studies, our results suggest that ER might be a feasible and safe treatment strategy compared to that of gastrectomy for EGC; however, careful endoscopic surveillance is needed for ensuring favorable outcomes. These findings should be confirmed in further large-scale, prospective, randomized, controlled trials from different countries.

title: Endoscopic resection versus surgery for early XXXX : a systematic review and meta-analysis.

answer: @entity1


abstract: OBJECTIVES: Quantitative ultrasound estimates such as the frequency-dependent backscatter coefficient (BSC) have the potential to enhance noninvasive tissue characterization and to identify @entity0 better than traditional B-mode imaging. Thus, investigating system independence of BSC estimates from multiple imaging platforms is important for assessing their capabilities to detect tissue differences. METHODS: @entity1 and @entity2 @entity0 models, 4T1 and MAT, respectively, were used in a comparative experiment using 3 imaging systems ( @entity3 , Ultrasonix, and VisualSonics) with 5 different transducers covering a range of ultrasonic frequencies. RESULTS: Functional analysis of variance of the MAT and 4T1 BSC-versus-frequency curves revealed statistically significant differences between the two @entity0 types. Variations also were found among results from different transducers, attributable to frequency range effects. At 3 to 8 MHz, @entity0 BSC functions using different systems showed no differences between @entity0 type, but at 10 to 20 MHz, there were differences between 4T1 and MAT @entity0 . Fitting an average spline model to the combined BSC estimates (3-22 MHz) demonstrated that the BSC differences between @entity0 increased with increasing frequency, with the greatest separation above 15 MHz. Confining the analysis to @entity0 resulted in better discrimination over a wider bandwidth. CONCLUSIONS: Confining the comparison to higher ultrasonic frequencies or larger @entity0 sizes allowed for separation of BSC-versus-frequency curves from 4T1 and MAT @entity0 . These constraints ensure that a greater fraction of the backscattered signals originated from within the @entity0 , thus demonstrating that statistically significant @entity0 differences were detected.

title: Quantitative Ultrasound Comparison of MAT and 4T1 Mammary Tumors in XXXX and @entity2 Across Multiple Imaging Systems.

answer: @entity1


abstract: OBJECTIVES: Quantitative ultrasound estimates such as the frequency-dependent backscatter coefficient (BSC) have the potential to enhance noninvasive tissue characterization and to identify @entity0 better than traditional B-mode imaging. Thus, investigating system independence of BSC estimates from multiple imaging platforms is important for assessing their capabilities to detect tissue differences. METHODS: @entity1 and @entity2 @entity0 models, 4T1 and MAT, respectively, were used in a comparative experiment using 3 imaging systems ( @entity3 , Ultrasonix, and VisualSonics) with 5 different transducers covering a range of ultrasonic frequencies. RESULTS: Functional analysis of variance of the MAT and 4T1 BSC-versus-frequency curves revealed statistically significant differences between the two @entity0 types. Variations also were found among results from different transducers, attributable to frequency range effects. At 3 to 8 MHz, @entity0 BSC functions using different systems showed no differences between @entity0 type, but at 10 to 20 MHz, there were differences between 4T1 and MAT @entity0 . Fitting an average spline model to the combined BSC estimates (3-22 MHz) demonstrated that the BSC differences between @entity0 increased with increasing frequency, with the greatest separation above 15 MHz. Confining the analysis to @entity0 resulted in better discrimination over a wider bandwidth. CONCLUSIONS: Confining the comparison to higher ultrasonic frequencies or larger @entity0 sizes allowed for separation of BSC-versus-frequency curves from 4T1 and MAT @entity0 . These constraints ensure that a greater fraction of the backscattered signals originated from within the @entity0 , thus demonstrating that statistically significant @entity0 differences were detected.

title: Quantitative Ultrasound Comparison of MAT and 4T1 Mammary Tumors in @entity1 and XXXX Across Multiple Imaging Systems.

answer: @entity2


abstract: UNASSIGNED: Background: Plasma @entity2 ( @entity3 ) level has been negatively correlated with the severity of @entity1 ( @entity1 ). Although @entity3 is widely used today, the results of individual randomized controlled trials of @entity3 -enriched nutrition support for @entity0 with @entity1 are conflicting. Methods: PubMed, EMBASE, HighWire, Cochrane Central Register of Controlled Trials, Wanfang, China Journals Full-Text Database, and the Chinese Biomedical Literature Database were searched. Literature published before June 2014 was searched. Randomized controlled trials investigating the comparison of conventional and @entity3 -enriched nutrition support were included; a random effect model using Rev @entity0 5.2 software was chosen to complete this meta-analysis. The count data were analyzed using the risk ratio (RR) and 95% confidence interval (CI), and the measurement data were analyzed using the standard mean difference or weighted mean difference and 95% CI. Heterogeneity analyses were conducted by I(2) test; publication bias analyses were conducted by Begg test. Results: Ten studies were eventually chosen for analysis, including 218 @entity0 who received conventional methods (control group) and 215 @entity0 who received @entity3 -enriched nutrition support (experimental group). Compared with the control group, @entity3 is helpful in elevating the albumin level, decreasing C-reaction protein (standard mean difference = 1.01, -1.89; 95% CI: 0.50 to 1.51, -3.23 to -0.56; P < .05), decreasing the incidence of infectious complication and mortality (RR = 0.62, 0.36; 95% CI: 0.46 to 0.83, 0.16 to 0.83; P < .05), and shortening the hospital stay length (weighted mean difference [WMD] = -3.89; 95% CI: -4.98 to -2.81; P < .05) without increasing expenses (WMD = -0.16; 95% CI: -1.34 to 1.02; P > .05). Intravenous infusion manifested more advantages by decreasing the incidence of infectious complications and mortality. Conclusions: @entity3 -enriched nutrition support is superior to conventional methods for @entity1 , and intravenous infusion may be a better choice for drug administration.

title: Efficacy of XXXX -Enriched Nutrition Support for @entity0 With Severe Acute Pancreatitis: A Meta-analysis.

answer: @entity2


abstract: UNASSIGNED: Background: Plasma @entity2 ( @entity3 ) level has been negatively correlated with the severity of @entity1 ( @entity1 ). Although @entity3 is widely used today, the results of individual randomized controlled trials of @entity3 -enriched nutrition support for @entity0 with @entity1 are conflicting. Methods: PubMed, EMBASE, HighWire, Cochrane Central Register of Controlled Trials, Wanfang, China Journals Full-Text Database, and the Chinese Biomedical Literature Database were searched. Literature published before June 2014 was searched. Randomized controlled trials investigating the comparison of conventional and @entity3 -enriched nutrition support were included; a random effect model using Rev @entity0 5.2 software was chosen to complete this meta-analysis. The count data were analyzed using the risk ratio (RR) and 95% confidence interval (CI), and the measurement data were analyzed using the standard mean difference or weighted mean difference and 95% CI. Heterogeneity analyses were conducted by I(2) test; publication bias analyses were conducted by Begg test. Results: Ten studies were eventually chosen for analysis, including 218 @entity0 who received conventional methods (control group) and 215 @entity0 who received @entity3 -enriched nutrition support (experimental group). Compared with the control group, @entity3 is helpful in elevating the albumin level, decreasing C-reaction protein (standard mean difference = 1.01, -1.89; 95% CI: 0.50 to 1.51, -3.23 to -0.56; P < .05), decreasing the incidence of infectious complication and mortality (RR = 0.62, 0.36; 95% CI: 0.46 to 0.83, 0.16 to 0.83; P < .05), and shortening the hospital stay length (weighted mean difference [WMD] = -3.89; 95% CI: -4.98 to -2.81; P < .05) without increasing expenses (WMD = -0.16; 95% CI: -1.34 to 1.02; P > .05). Intravenous infusion manifested more advantages by decreasing the incidence of infectious complications and mortality. Conclusions: @entity3 -enriched nutrition support is superior to conventional methods for @entity1 , and intravenous infusion may be a better choice for drug administration.

title: Efficacy of @entity2 -Enriched Nutrition Support for XXXX With Severe Acute Pancreatitis: A Meta-analysis.

answer: @entity0


abstract: Objective. To describe the relation between @entity1 and @entity2 ( @entity2 ) in preschool @entity0 from Mexico. Material and methods. Information of 10 513 preschool @entity0 and their families was analyzed. The @entity2 was measured through the Latin American and Caribbean Food Security Scale (ELCSA). Adjusted prevalence of @entity2 and @entity1 with related variables were assessed by logistic regression. Results. 31% of households had moderate and server @entity2 . Rural and south, indigenous households, in the Q1 and Q2, showed the highest prevalence of moderate and severe @entity2 as well. We observed a high tendency of @entity1 in the severe @entity2 group; the prevalence of overweight was similar in the four groups of @entity2 . Conclusions. The risk of chronic @entity1 is 42% bigger in @entity0 less than five years old with severe @entity2 than in those that experienced food security.

title: [Food insecurity and nutritional status of preschool XXXX in Mexico].

answer: @entity0


abstract: PURPOSE: To investigate the effects of @entity2 on emotional control in adults with @entity1 . METHODS: We performed an integrated analysis using individual @entity0 data pooled from three Eli Lilly-sponsored studies. An integrated analysis can be viewed as a meta-analysis of individual @entity0 -level data, rather than study-level summary data. RESULTS: Two populations were identified: a large sample of @entity0 with pre-treatment baseline data (the "overall population"; n=2846); and a subset of these @entity0 with placebo-controlled efficacy data from baseline to 10 or 12weeks after initiating treatment (the "placebo-controlled population"; n=829). At baseline, in the overall population,    50% of @entity1 @entity0 had BRIEF-AS (Behavior Rating Inventory of Executive Function-Adult Version Self-Report) Emotional control subscores between 21 and 30, compared with    10% of normative subjects in the BRIEF-A manual. At endpoint, in the placebo-controlled population, @entity2 led to a small (effect size 0.19) but significant (P=0.013) treatment effect for emotional control. The effect size was 0.32 in @entity0 with BRIEF-AS Emotional control scores>20 at baseline. Improvements in emotional control correlated with improvements in the core @entity1 symptoms and quality-of-life. DISCUSSION: As deficient emotional control is associated with impaired social, educational and occupational functioning over and above that explained by core @entity1 symptoms alone, improvements in emotional control may be clinically relevant. CONCLUSION: At baseline, adults with @entity1 were more likely to have impaired emotional control than normative subjects. In the adult @entity1 @entity0 , @entity2 treatment was associated with improvements in emotional control, as well as in core @entity1 symptoms and quality-of-life.

title: The effects of XXXX on emotional control in adults with @entity1 : An integrated analysis of multicenter studies.

answer: @entity2


abstract: PURPOSE: To investigate the effects of @entity2 on emotional control in adults with @entity1 . METHODS: We performed an integrated analysis using individual @entity0 data pooled from three Eli Lilly-sponsored studies. An integrated analysis can be viewed as a meta-analysis of individual @entity0 -level data, rather than study-level summary data. RESULTS: Two populations were identified: a large sample of @entity0 with pre-treatment baseline data (the "overall population"; n=2846); and a subset of these @entity0 with placebo-controlled efficacy data from baseline to 10 or 12weeks after initiating treatment (the "placebo-controlled population"; n=829). At baseline, in the overall population,    50% of @entity1 @entity0 had BRIEF-AS (Behavior Rating Inventory of Executive Function-Adult Version Self-Report) Emotional control subscores between 21 and 30, compared with    10% of normative subjects in the BRIEF-A manual. At endpoint, in the placebo-controlled population, @entity2 led to a small (effect size 0.19) but significant (P=0.013) treatment effect for emotional control. The effect size was 0.32 in @entity0 with BRIEF-AS Emotional control scores>20 at baseline. Improvements in emotional control correlated with improvements in the core @entity1 symptoms and quality-of-life. DISCUSSION: As deficient emotional control is associated with impaired social, educational and occupational functioning over and above that explained by core @entity1 symptoms alone, improvements in emotional control may be clinically relevant. CONCLUSION: At baseline, adults with @entity1 were more likely to have impaired emotional control than normative subjects. In the adult @entity1 @entity0 , @entity2 treatment was associated with improvements in emotional control, as well as in core @entity1 symptoms and quality-of-life.

title: The effects of @entity2 on emotional control in adults with XXXX : An integrated analysis of multicenter studies.

answer: @entity1


abstract: 1. Cortical slices from @entity0 brain were incubated in media containing the irreversible cholinesterase inhibitor soman and a high KCl concentration, and the release and synthesis of @entity2 ( @entity4 ) were determined.2. @entity7 enhanced the release and synthesis of @entity4 .3. @entity3 , a substance which blocks nervous conduction, did not influence the release and synthesis of @entity4 , in the absence or in the presence of @entity7 . Therefore the nerve endings are probably the site at which @entity7 acts when stimulating the release and synthesis of @entity4 .4. Pretreatment of the slices with botulinum type A toxin partially blocked the release and synthesis of @entity4 and reduced the extra amounts of @entity4 released and synthesized under the influence of @entity7 .5. Lowering the @entity1 or raising the @entity5 concentration in the incubation medium reduced the release and synthesis of @entity4 and their enhancement by @entity7 .6. @entity6 decreased the total extractable @entity4 content of the slices during incubation in a 25 mM @entity8 containing medium. This decrease was nearly prevented when the release and synthesis of @entity4 were inhibited by omission of the @entity1 ions from the medium, but was enhanced by @entity7 .7. The observations made with pretreatment by botulinum type A toxin, with changes in the @entity1 and @entity5 concentration as well as with @entity6 , all support the theory that it is primarily the release of @entity4 which is enhanced by @entity7 and that its stimulating action on the synthesis results from the increased release.

title: Stimulation by @entity7 of XXXX release and synthesis in cortical slices from @entity0 brain.

answer: @entity2


abstract: 1. Cortical slices from @entity0 brain were incubated in media containing the irreversible cholinesterase inhibitor soman and a high KCl concentration, and the release and synthesis of @entity2 ( @entity4 ) were determined.2. @entity7 enhanced the release and synthesis of @entity4 .3. @entity3 , a substance which blocks nervous conduction, did not influence the release and synthesis of @entity4 , in the absence or in the presence of @entity7 . Therefore the nerve endings are probably the site at which @entity7 acts when stimulating the release and synthesis of @entity4 .4. Pretreatment of the slices with botulinum type A toxin partially blocked the release and synthesis of @entity4 and reduced the extra amounts of @entity4 released and synthesized under the influence of @entity7 .5. Lowering the @entity1 or raising the @entity5 concentration in the incubation medium reduced the release and synthesis of @entity4 and their enhancement by @entity7 .6. @entity6 decreased the total extractable @entity4 content of the slices during incubation in a 25 mM @entity8 containing medium. This decrease was nearly prevented when the release and synthesis of @entity4 were inhibited by omission of the @entity1 ions from the medium, but was enhanced by @entity7 .7. The observations made with pretreatment by botulinum type A toxin, with changes in the @entity1 and @entity5 concentration as well as with @entity6 , all support the theory that it is primarily the release of @entity4 which is enhanced by @entity7 and that its stimulating action on the synthesis results from the increased release.

title: Stimulation by XXXX of @entity2 release and synthesis in cortical slices from @entity0 brain.

answer: @entity7


abstract: 1. Cortical slices from @entity0 brain were incubated in media containing the irreversible cholinesterase inhibitor soman and a high KCl concentration, and the release and synthesis of @entity2 ( @entity4 ) were determined.2. @entity7 enhanced the release and synthesis of @entity4 .3. @entity3 , a substance which blocks nervous conduction, did not influence the release and synthesis of @entity4 , in the absence or in the presence of @entity7 . Therefore the nerve endings are probably the site at which @entity7 acts when stimulating the release and synthesis of @entity4 .4. Pretreatment of the slices with botulinum type A toxin partially blocked the release and synthesis of @entity4 and reduced the extra amounts of @entity4 released and synthesized under the influence of @entity7 .5. Lowering the @entity1 or raising the @entity5 concentration in the incubation medium reduced the release and synthesis of @entity4 and their enhancement by @entity7 .6. @entity6 decreased the total extractable @entity4 content of the slices during incubation in a 25 mM @entity8 containing medium. This decrease was nearly prevented when the release and synthesis of @entity4 were inhibited by omission of the @entity1 ions from the medium, but was enhanced by @entity7 .7. The observations made with pretreatment by botulinum type A toxin, with changes in the @entity1 and @entity5 concentration as well as with @entity6 , all support the theory that it is primarily the release of @entity4 which is enhanced by @entity7 and that its stimulating action on the synthesis results from the increased release.

title: Stimulation by @entity7 of @entity2 release and synthesis in cortical slices from XXXX brain.

answer: @entity0


abstract: UNASSIGNED: Some progress has been made regarding availability of recombinant factor @entity3 concentrates and prophylaxis for @entity1 in emerging countries, where plasma-derived concentrates were used in the vast majority. Clinical studies to document their introduction and effectiveness are so far not widely available in literature. This non-interventional study evaluates the real-life effectiveness and safety of prophylactic and on-demand treatment with recombinant factor @entity3 formulated with sucrose (rFVIII-FS) for bleed control and preservation of joints in emerging countries from Eastern Europe, North Africa and Middle East area. One hundred and eighty-six @entity0 from 11 countries were enrolled, mean      SD age 12.8      12.7  years. At enrolment, majority (79.6%) had severe @entity1 (<2%  IU  mL(-1) ), 47.8% had a target joint, 15% had an inhibitor history and one @entity0 was on immune tolerance induction. During the 24-month observation period, 58.1% of the @entity0 were prescribed prophylaxis at every visit, 31.7% were on an on-demand regimen. @entity0 with severe @entity1 on prophylaxis (n  =  82) had a mean annual rate of treated @entity2 of 2.8      4.4, whereas it was 19.1      32.0 for the on-demand group (n  =  31), and a mean total Gilbert Score of 9.9      10.3 at baseline and 4.1      6.7 at study end; vs. 15.2      17.3 and 13.7      17.1 for on-demand respectively. The majority of the @entity2 (91.1%) were treated with one or two infusions. Four @entity0 without inhibitor history had a first positive inhibitor test during the study. This study demonstrates the effective use of rFVIII-FS in emerging countries and adds to the established safety profile of rFVIII-FS.

title: Real-life evidence in evaluating effectiveness of treatment in XXXX with a recombinant FVIII concentrate: A non-interventional study in emerging countries.

answer: @entity1


abstract: OBJECTIVE: To determine the incidence and predisposing factors of @entity1 during anesthetic induction in lung transplant recipients. DESIGN: Retrospective study. SETTING: University hospital. @entity0 : @entity0 who underwent lung transplantation between 2008 and 2013 (n = 68). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The authors analyzed the mean arterial pressure (MAP) from administration of anesthetic drugs to 10 minutes after endotracheal intubation (ie, the anesthetic induction) among @entity0 who underwent lung transplantation. @entity0 were considered to have clinically significant @entity1 (CSH) when the following criteria were fulfilled: An MAP decrease of>40% from baseline and MAP of<60 mmHg. Overall, 41.2% of @entity0 experienced CSH during the induction of anesthesia. The preoperative partial pressure of carbon dioxide (PaCO2) was significantly higher in @entity0 who experienced CSH during anesthetic induction than in those who did not (p = 0.005). Preoperative PaCO2 predicted the development of CSH during anesthetic induction (area under the curve = 0.702; p = 0.002), with an optimal cut-off point of 55 mmHg determined by maximizing the Youden index. The incidences of CSH during anesthetic induction for @entity0 with (PaCO2>= 55) and without (PaCO2<55) preoperative @entity2 were 75.0% (95% confidence interval [CI] [53.8-89.2]) and 30.8% (95% CI 26.4-37.3), respectively. After adjustment for known predicting factors, the odds ratio for the relationship between preoperative @entity2 and CSH during anesthetic induction was 12.54 (95% CI 3.10-66.66). CONCLUSIONS: @entity1 during anesthetic induction is common in lung transplant recipients, and is independently predicted by preoperative @entity2 .

title: Preoperative @entity2 as a Predictor of XXXX During Anesthetic Induction in Lung Transplant Recipients.

answer: @entity1


abstract: OBJECTIVE: To determine the incidence and predisposing factors of @entity1 during anesthetic induction in lung transplant recipients. DESIGN: Retrospective study. SETTING: University hospital. @entity0 : @entity0 who underwent lung transplantation between 2008 and 2013 (n = 68). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The authors analyzed the mean arterial pressure (MAP) from administration of anesthetic drugs to 10 minutes after endotracheal intubation (ie, the anesthetic induction) among @entity0 who underwent lung transplantation. @entity0 were considered to have clinically significant @entity1 (CSH) when the following criteria were fulfilled: An MAP decrease of>40% from baseline and MAP of<60 mmHg. Overall, 41.2% of @entity0 experienced CSH during the induction of anesthesia. The preoperative partial pressure of carbon dioxide (PaCO2) was significantly higher in @entity0 who experienced CSH during anesthetic induction than in those who did not (p = 0.005). Preoperative PaCO2 predicted the development of CSH during anesthetic induction (area under the curve = 0.702; p = 0.002), with an optimal cut-off point of 55 mmHg determined by maximizing the Youden index. The incidences of CSH during anesthetic induction for @entity0 with (PaCO2>= 55) and without (PaCO2<55) preoperative @entity2 were 75.0% (95% confidence interval [CI] [53.8-89.2]) and 30.8% (95% CI 26.4-37.3), respectively. After adjustment for known predicting factors, the odds ratio for the relationship between preoperative @entity2 and CSH during anesthetic induction was 12.54 (95% CI 3.10-66.66). CONCLUSIONS: @entity1 during anesthetic induction is common in lung transplant recipients, and is independently predicted by preoperative @entity2 .

title: Preoperative XXXX as a Predictor of @entity1 During Anesthetic Induction in Lung Transplant Recipients.

answer: @entity2


abstract: OBJECTIVE: To evaluate the risk factors of @entity1 and whether previous @entity4 flaccidity predisposes to it in consecutive, mechanically ventilated, intensive care unit @entity0 undergoing different percutaneous dilatational tracheostomy procedures (Ciaglia Blue Rhino, PercuTwist, and Ciaglia BlueDolphin). DESIGN: Single-center retrospective study performed between November 2006 and July 2013. SETTING: Single-center university hospital. @entity0 : Two hundred nineteen consecutive intensive care unit @entity0 . INTERVENTIONS: Video bronchoscopic percutaneous dilatational tracheostomies using different techniques, including Ciaglia Blue Rhino, PercuTwist, and Ciaglia BlueDolphin, were performed consecutively. During the procedure, the tracheal wall response to the routine external palpation was evaluated endoscopically to find the interanular space. An abnormal change in the @entity4 shape (fingerprint) with anterior airway wall collapse was diagnosed as @entity3 . MEASUREMENTS AND MAIN RESULTS: @entity1 occurred in 21 @entity0 (9.6%). The proportion of @entity2 was 16 (76.2%) after PercuTwist, 3 (14.3%) after Ciaglia Blue Dolphin, and 2 (9.5%) after the Blue Rhino technique. Significant risk factors for @entity2 were PercuTwist procedure (p = 0.02), @entity3 (p = 0.0001), and a period of intubation before a percutaneous dilatational tracheostomy procedure>14 days (p = 0.01). CONCLUSIONS: In addition to the PercuTwist technique and intubation>14 days before tracheostomy, @entity3 was a significant risk factor for @entity1 . In the presence of this finding, a less traumatic tracheostomy procedure should be applied.

title: XXXX Fracture Secondary to Percutaneous Tracheostomy: Is Tracheal Flaccidity a Risk Factor?

answer: @entity4


abstract: @entity4 ( @entity4 ) in @entity0 is strongly associated with @entity1 and mortality, and prevalent abnormal lipid metabolism. The AIM-HIGH trial examined the benefits of adding extended-release niacin (ERN) to simvastatin in @entity0 with established @entity2 . Here we conducted a post hoc analysis of the AIM-HIGH trial examining whether @entity0 derived cardiovascular or renal benefits when stratified by renal function. Of 3414 @entity0 , 505 had stage 3 @entity4 at baseline. Among the @entity4 subset, demographics and @entity1 ( @entity1 ) risk factors were well balanced in the ERN and placebo arms. Compared with placebo, @entity4 @entity0 receiving ERN had a significant decrease in triglycerides by a median of 59.0   mg/dl, and high-density lipoprotein cholesterol significantly increased by a mean of 11.3   mg/dl over a mean follow-up of 3 years. @entity1 events were similar between @entity4 @entity0 in both arms. However, all-cause mortality was significantly higher in the ERN group (hazard ratio of 1.73). Mean change in @entity3 among ERN-treated @entity4 @entity0 was not significantly different between study arms. Thus, among AIM-HIGH @entity0 with @entity4 , the addition of ERN to simvastatin for secondary prevention of @entity1 improved triglyceride and high-density lipoprotein-cholesterol concentrations but did not improve cardiovascular outcomes or kidney function, and was associated with higher all-cause mortality.

title: Effect of extended-release niacin on cardiovascular events and kidney function in XXXX : a post hoc analysis of the AIM-HIGH trial.

answer: @entity4


abstract: OBJECTIVE: This review investigates the relationship between leg muscle power and the chronic conditions of @entity3 , @entity0 , and @entity1 among older adults. Current literature assessing the impact of @entity2 on leg power has not yet been comprehensively characterized. Importantly, individuals with these conditions have shown improved leg power with training. METHODS: A search was performed using PubMed to identify original studies published in English from January 1998 to August 2013. Leg power studies, among older adults >=  50 years of age, which assessed associations with @entity3 , @entity0 , and/or @entity1 were selected. Studies concerning post-surgery rehabilitation, case studies, and articles that did not measure primary results were excluded. RESULTS: Sixteen studies met inclusion criteria, addressing @entity3 (n=5), @entity0 (n=5), and @entity1 (n=6). Studies generally supported associations of lower leg power among older adults with @entity2 , although small sample sizes, cross-sectional data, homogenous populations, varied disease definitions, and inconsistent leg power methods limited conclusions. CONCLUSIONS: Studies suggest that @entity3 , @entity0 , and @entity1 are associated with lower leg power compared to older adults without these conditions. These studies are limited, however, by the heterogeneity in study populations and a lack of standardized measurements of leg power. Future larger studies of more diverse older adults with well-defined @entity2 using standard measures of leg power and interventions to improve leg power in these older adults with @entity2 are needed.

title: A review of the relationship between leg power and selected XXXX in older adults.

answer: @entity2


abstract: MicroRNAs (miRNAs) are ~22 base pair-long non-coding RNAs which regulate gene expression in the cytoplasm of eukaryotic cells by binding to specific target regions in mRNAs to mediate transcriptional blocking or mRNA cleavage. Through their fundamental roles in cellular pathways, gene regulation mediated by miRNAs has been shown to be involved in almost all biological phenomena, including development, metabolism, cell cycle, @entity1 formation, and host-pathogen interactions. To address the latter in a primitive vertebrate host, we here used an array platform to analyze the miRNA response in @entity3 ( @entity3 ) following inoculation with the virulent fish rhabdovirus @entity2 virus. Two clustered miRNAs, miR-462 and miR-731 (herein referred to as miR-462 cluster), described only in teleost fishes, were found to be strongly upregulated, indicating their involvement in fish-virus interactions. We searched for homologues of the two teleost miRNAs in other vertebrate species and investigated whether findings related to ours have been reported for these homologues. Gene synteny analysis along with gene sequence conservation suggested that the teleost fish miR-462 and miR-731 had evolved from the ancestral @entity4 and @entity5 (herein called @entity4 cluster), respectively. Whereas the miR-462 cluster locus is found between two protein-coding genes (intergenic) in teleost fish genomes, the @entity4 cluster locus is found within an intron of a protein-coding gene (intragenic) in the @entity0 genome. Interferon (IFN)-inducible and immune-related promoter elements found upstream of the teleost miR-462 cluster locus suggested roles in immune responses to viral pathogens in fish, while in @entity0 , the @entity4 cluster functionally associated with cell cycle regulation. Stimulation of fish cell cultures with the IFN inducer poly I:C accordingly upregulated the expression of miR-462 and miR-731, while no stimulatory effect on @entity4 and @entity5 expression was observed in @entity0 cell lines. Despite high sequence conservation, evolution has thus resulted in different regulation and presumably also different functional roles of these orthologous miRNA clusters in different vertebrate lineages.

title: Two Virus-Induced MicroRNAs Known Only from Teleost Fishes Are Orthologues of MicroRNAs Involved in Cell Cycle Control in XXXX .

answer: @entity0


abstract: UNASSIGNED: Introduction: The beginning of the nano-era started with the appearance of artificial nanosized supramolecular systems called nanomaterials and nanoparticles (NPs). Areas covered: In the present review, we have analyzed the patents on @entity4 -based nanomaterials ( @entity6 , quantum dots [QDs], @entity5 , liposomes, dendrimers, gold and @entity3 NPs) in biology and medicine. Their impact in treatment of @entity0 and @entity1 is discussed. Expert opinion: Liposomes and dendrimers had the highest number of biomedical patents. The third candidates were QDs and the fourth and fifth were gold and @entity3 NPs. @entity6 and @entity2 nanotubes have the fewest applications in biology and medicine. Thus, our first conclusion was about the 'unifying nanotoxicology paradigm', that 'soft' NPs are significantly more biocompatible than 'hard' NPs. There has been a trend of these nanomaterials being applied in medicine drug and gene delivery, visualization of cells and pathologic processes, using them as antivirals and antimicrobials, contrast agents, antioxidants and photosensitizers. It was unexpected that no patents were found in which @entity4 NPs were used in 3D printing of bones and other biological tissues. The conclusion reached is that nanomaterials are promising tools in future medical applications.

title: XXXX -containing nanoparticles: biomedical patents review.

answer: @entity4


abstract: UNASSIGNED: Transformation of @entity1 ( @entity1 ) into aggressive disease and relapse of de novo @entity2 ( @entity2 ) are considered highly unfavourable events. However, most published data were acquired when rituximab was not routinely used. We retrospectively analysed 50 @entity0 with transformed @entity1 (tFL) in a multicenter study and compared them to 50 individuals with relapsed @entity2 (rDLBCL) who all obtained rituximab for the treatment of their disease. Our goal was to identify factors that predict a more favourable prognosis. After a median follow-up of 5.4  years from diagnosis, there was no significant difference in median overall survival (OS) from the date of transformation (tFL) or date of the first relapse (rDLBCL) (1.9 versus 3.9  years, P   =   .542). Of note, 5-year OS of @entity0 with tFL was 46  %. @entity1 @entity0 , treatment na  ve prior to transformation, fared significantly better than pretreated @entity0 (median not reached versus 1.4  years, P   =   .014). Regarding rDLBCL, female gender (13.9 versus 1.8  years, P   =   .019) and absence of rituximab prior to the first relapse (14.0 versus 1.8  years, P   =   .035) were favourable prognostic factors in a uni- and multivariate analysis. Only a proportion of @entity0 received high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT), i.e. 38 and 52  % of @entity0 with tFL and rDLBCL, respectively. Our data indicate that a favourable prognosis is conferred by treatment naivety in tFL and by rituximab naivety in rDLBCL. In contrast, we did not find a prognostic impact of HDT-ASCT in our series.

title: Impact of prior treatment on outcome of transformed @entity1 and relapsed de novo XXXX : a retrospective multicentre analysis.

answer: @entity2


abstract: UNASSIGNED: Transformation of @entity1 ( @entity1 ) into aggressive disease and relapse of de novo @entity2 ( @entity2 ) are considered highly unfavourable events. However, most published data were acquired when rituximab was not routinely used. We retrospectively analysed 50 @entity0 with transformed @entity1 (tFL) in a multicenter study and compared them to 50 individuals with relapsed @entity2 (rDLBCL) who all obtained rituximab for the treatment of their disease. Our goal was to identify factors that predict a more favourable prognosis. After a median follow-up of 5.4  years from diagnosis, there was no significant difference in median overall survival (OS) from the date of transformation (tFL) or date of the first relapse (rDLBCL) (1.9 versus 3.9  years, P   =   .542). Of note, 5-year OS of @entity0 with tFL was 46  %. @entity1 @entity0 , treatment na  ve prior to transformation, fared significantly better than pretreated @entity0 (median not reached versus 1.4  years, P   =   .014). Regarding rDLBCL, female gender (13.9 versus 1.8  years, P   =   .019) and absence of rituximab prior to the first relapse (14.0 versus 1.8  years, P   =   .035) were favourable prognostic factors in a uni- and multivariate analysis. Only a proportion of @entity0 received high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT), i.e. 38 and 52  % of @entity0 with tFL and rDLBCL, respectively. Our data indicate that a favourable prognosis is conferred by treatment naivety in tFL and by rituximab naivety in rDLBCL. In contrast, we did not find a prognostic impact of HDT-ASCT in our series.

title: Impact of prior treatment on outcome of transformed XXXX and relapsed de novo @entity2 : a retrospective multicentre analysis.

answer: @entity1


abstract: OBJECTIVE: To evaluate the mean duration of treatment course with fondaparinux 2.5mg ( @entity3 (  )) in the setting of ambulatory general medicine, with respect to its indication in thromboprophylaxis for medically ill @entity0 and to describe the population treated. METHODS: Observational, prospective, national, multicenter, pharmaco-epidemiological study, performed in France, at the request of the Transparency Commission (a division of the French Health Regulatory Authority). The general practitioners had to include the first three adult @entity0 , considered as @entity0 at high risk of venous @entity1 and immobilized for acute medical illness, treated with initiation of thromboprophylaxis by fondaparinux 2.5mg. RESULTS: Two hundred and seventeen general practitioners included 840 @entity0 . The mean age of @entity0 was 63.6  18.1years, and 63% of @entity0 (n=520/831) were females. The real total administration duration of the treatment by fondaparinux 2.5mg was known for 797 @entity0 and was 15.8  12.4 days on average (range: 1-90days, median: 10days). In 40% of @entity0 , the duration ranged from 6 to 14days [duration consistent with the summary of product characteristics (SmPC)]. Among the 834 @entity0 analyzed, 569 (68%) suffered from at least one acute illness and had at least one risk factor for @entity2 ( @entity2 ). The indication did fully comply with the summary of product characteristics of fondaparinux 2.5mg in 52% of the @entity0 (n=434/834 @entity0 ). CONCLUSION: The results of the ArchiMed study support that the thromboprophylaxis treatment with fondaparinux 2.5mg in ambulatory general medicine, and the associated medical conditions were usually consistent with the SmPC or guidelines. However, a difference was found for the duration and the initial indication, in situations that may be regarded as presenting a risk by the prescriber.

title: [Prevention of venous XXXX by fondaparinux 2.5mg in general practice. ArchiMed Ville].

answer: @entity1


abstract: The authors have studied the anatomic variations of the @entity1 (N. @entity2 ) in 18 @entity0 heads. The mandibular nerve being free by medial abord. At about half of the studied cases the M. pterygoideus medialis presents a widened insertion extending on the posterior border of the Ramus mandibulae. Before entering into the mandibular channel the @entity1 separated from the next elements by expansion of "apon  vrose interpt  rygoidienne". At this level gets sympathic branches from the plexus caroticus externus et internus, making a plexiform structure interfering sometimes a vegetative ganglion formation. At 16.6% of the cases between the @entity1 are established connection bridges more or less developed. They have an asymetric aspect. There were observed evident connections between the @entity1 and the @entity3 taking a mono- or pluriradicular form. The mylohyoidian nerve on his homonymous way gives 2--3 sensitive, or vegetative branches to the bone. Practically speaking are important the branches coming from the precanalicular portion of n. @entity2 perforating the periost and penetrating independently in to mandibula through separated vents. These results are practically useful in Stomatological technique explaining from an anatomically point of view the inefficiency of mandibular anaesthesia in some cases although it is correctly applied.

title: [Anatomical variations of the nervus XXXX and their importance for the practice (author's transl)].

answer: @entity2