abstract: The aim of this study was to review our experience with a treatment regimen that combined conventionally fractionated radiation therapy (70 Gy over 7 weeks) with chemotherapy ( @entity5 and @entity6 ), given concurrently in the last 2 weeks of radiation therapy in @entity0 with previously untreated advanced @entity2 region.Twenty-eight @entity0 , all but two having UICC stage IV disease, were treated at the Peter MacCallum Cancer Institute between November 1995 and April 1998. Planned chemotherapy consisted initially of continuous infusion at 10 mg/m(2) per day of @entity5 and 400 mg/m(2) per day of @entity6 on days 1-5 of weeks 6 and 7 of a conventionally fractionated course of radiotherapy. After the first 14 @entity0 , the dose of @entity6 was reduced to 360 mg/m(2) per day because of acute @entity3 .36.8 months), with an estimated 50% surviving at 2 years (CI, 29-71%). Sixteen @entity0 (57%) developed confluent @entity1 and 11 (39%) developed @entity1 . The median duration of @entity1 for these 27 @entity0 was 1.5 months. Seventeen @entity0 (61%) required nutritional support for a median duration of 1.4 months. Fourteen @entity0 (50%) had grade three skin reactions, and 12 (43%) had one or more other significant (Grade 3) @entity3 , predominantly infective. Grade 3 late @entity3 has been observed in three @entity0 to date (three @entity7 , including one with severe @entity4 ), and one @entity0 had chronic ulceration of the oral tongue (grade 4). This chemoradiation regimen achieved an excellent complete response rate and good locoregional control at 2 years in @entity0 with a poor initial prognosis. Acute @entity3 was significant but manageable. The regimen offers an alternative to surgery and postoperative radiation therapy in locally advanced @entity2 .

title: Radiation with concurrent late chemotherapy intensification ('chemoboost') for locally advanced XXXX .

answer: @entity2


abstract: AIM: To examine the parent-dependent barriers to @entity2 immunization in Israel. METHODS: Data were collected by questionnaire from parents of @entity0 aged 1 to 18 years who attended an outpatient paediatric centre in five cities in Israel from March to May 2003. RESULTS: A total of 1474 parents completed the questionnaire. A history of @entity3 pox was reported in 850 @entity0 (57.8%), mostly (83%) between ages 1-6 years. Of the 624 @entity0 without a history of @entity3 pox, 213 (34.1%) were immunized against @entity2 . Immunization rates were significantly lower in families with lower parental education and in @entity0 from cities with a lower socioeconomic ranking (p < 0.05). The main reasons for not being vaccinated (49%) were related to insufficient information about the vaccine itself and the vaccination process. These reasons were more common in families with lower parental education and from cities with lower socioeconomic ranking (p < 0.01). Other reasons included fear of adverse effects (12%) and waning immunity (6%), preference of @entity1 over immunization (12%), and financial limitations (5%). CONCLUSIONS: Promoting parental knowledge about the @entity2 vaccine appears to be a key factor in improving the immunization rate, especially in families of lower education, and from cities with low socioeconomic ranking.

title: Parent-dependent barriers to XXXX immunization in Israel: the importance of adequate information.

answer: @entity2


abstract: PURPOSE: To compare conventional fractionation with hypofractionation in @entity0 with a @entity1 multiforme. Endpoints of the analysis are overall survival and palliative effect. MATERIALS AND METHODS: From 1988 to 1998, 155 @entity0 with pathologically confirmed @entity1 multiforme were prospectively analysed. @entity0 without @entity2 and @entity0 receiving an interstitial boost were excluded from this analysis. Three different radiation schemes were used in subsequent periods; 33x2, 8x5 and 4x7 Gy. In the last 5 years a scheme of 4x7 Gy conformal @entity2 was given to poor prognosis @entity0 . The more favourable group received the conventionally fractionated scheme up to 66 Gy. RESULTS: Median survival was 7, 5.6 and 6.6 months for the 33x2, 8x5 and 4x7 Gy, respectively. In general, @entity0 in the hypofractionation group had far worse prognostic factors compared with @entity0 treated with the conventional scheme. The period of neurological improvement or stabilisation was similar between the 4x7 and 33x2 Gy group. CONCLUSION: An extreme hypofractionation scheme of 4x7 Gy conformal @entity2 in poor prognostic @entity1 @entity0 is well tolerated, convenient for the @entity0 and provides equal palliation without negative effects on survival compared with conventional fractionation.

title: Hypofractionation in XXXX multiforme.

answer: @entity1


abstract: Within the International Classification of Functioning, Disability, and Health (ICF; WHO), participation in work is acknowledged as one of the major areas in life (D8). Difficulties that make it impossible for the @entity0 to optimally partake in work result in participation restriction. An increasing number of @entity0 with @entity1 are seeking help for @entity2 . Various studies identified issues that should be addressed in the management of employees with @entity1 and emphasized the importance of a tailored vocational enablement program. This paper describes a recently developed vocational enablement protocol (VEP) addressing the specific needs of those with @entity1 in the workforce. It is characterized by an integrated approach (occupational physician, otolaryngologist, audiologist, social worker/psychologist, speech-language pathologist). The goal is to facilitate participation in, and retention of, work. The protocol is currently implemented in a few audiological centers in the Netherlands. This paper presents data collected at the audiological center of the VU University Medical Center, Amsterdam. Thus far, 86 @entity0 , aged 19 to 64 years (mean 48, SD 23), have completed the protocol. Experiences with the procedure are described, and recommendations for future practice and research are discussed.

title: XXXX , work, and vocational enablement.

answer: @entity1


abstract: BACKGROUND: In vitro models are indispensable study objects in the fields of cell and molecular biology, with advantages such as accessibility, homogeneity of the cell population, reproducibility, and growth rate. The Caco-2 cell line, originating from a @entity2 , is a widely used in vitro model for small intestinal epithelium. @entity1 cells have an altered metabolism, making it difficult to infer their representativity for the tissue from which they are derived. This study was designed to compare the protein expression pattern of Caco-2 cells with the patterns of intestinal epithelial cells from @entity0 small and large intestine. HT-29 intestinal cells, Hep G2 liver cells and TE 671 muscle cells were included too, the latter two as negative controls. RESULTS: Two-dimensional gel electrophoresis was performed on each tissue and cell line protein sample. Principal component and cluster analysis revealed that global expression of intestinal epithelial scrapings differed from that of intestinal epithelial cell lines. Since all cultured cell lines clustered together, this finding was ascribed to an adaptation of cells to culture conditions and their @entity1 origin, and responsible proteins were identified by mass spectrometry. When investigating the profiles of Caco-2 cells and small intestinal cells in detail, a considerable overlap was observed. CONCLUSION: Numerous proteins showed a similar expression in Caco-2 cells, HT-29 cells, and both the intestinal scrapings, of which some appear to be characteristic to @entity0 intestinal epithelium in vivo. In addition, several biologically significant proteins are expressed at comparable levels in Caco-2 cells and small intestinal scrapings, indicating the usability of this in vitro model. Caco-2 cells, however, appear to over-express as well as under-express certain proteins, which needs to be considered by scientists using this cell line. Hence, care should be taken to prevent misinterpretation of in vitro obtained findings when translating them to the in vivo situation.

title: Comparative proteomic analysis of cell lines and scrapings of the XXXX intestinal epithelium.

answer: @entity0


abstract: INTRODUCTION: Twenty per cent of the operated @entity0 suffering from cryptorchidisim show no palpable @entity2 in the physical check-up. The use of a non-palpable @entity2 in the initial stages is considered to be controversial when deciding between a laparascopic or an inguinal approach. Our aim is to compare the results obtained with these two approaches and evaluate which one of them would be the most relevant as an initial option. MATERIALS AND METHODS: We examined the @entity0 who have been subjected to surgical intervention for non-palpable @entity2 in the last three years. We had a sample of 53 @entity0 . Bilateral non-palpable @entity2 were disregarded. In the case of 35 @entity0 the initial approach was through the groins while in 18 of them the approach was laparascopic. Relevant data were recorded, such as the age of the @entity0 , right or left side, surgical findings, need for a laparascopic or groin approach and associated @entity1 . RESULTS: The average age of the @entity0 at the time of the surgical treatment was 3.7 years R (1-13 years). 42% of the @entity2 were on the right side and 58% on the left. In an initial stage the inguinal approach was used with 35 @entity0 , 2 of these requiring laparascopic exploration due to a non-concluding check-up; it was concluded that they were 2 cases of @entity3 . An initial laparoscopic approach was used with 18 @entity0 . Internal vessels in the canal were found which required an inguinal approach. In 12 @entity0 normal or @entity4 @entity2 were observed. Testicular descent was achieved through the groin in 10 of them while in the remaining 2 a combined approach was adopted. CONCLUSIONS: 80% of the @entity0 subjected to a first laparoscopic approach needed a groin approach later on. 11% of the @entity0 subjected to a first inguinal approach required laparascopic examination. In view of the results obtained, we conclude that inguinal exploration diminishes the need for second procedures.

title: [Non-palpable XXXX : laparoscopic or inguinal approach?].

answer: @entity2


abstract: OBJECTIVE: High blood pressure (BP) is a leading risk factor for @entity1 and mortality. Effective antihypertensive pharmacotherapy is available but recognition and proper management of @entity2 and BP goal achievement is still poor. Therefore, it was hypothesized that physicians' attitude towards high BP, as well as @entity0 ' perception and knowledge, may influence actual management of @entity2 . RESEARCH DESIGN AND METHODS: Telephone interviews were carried out with a random sample of 1259 primary care physicians in 17 countries worldwide from 12 December 2005 to 13 January 2006 using a central computer assisted telephone interview methodology (CATI). RESULTS: (1) Physicians believed that 62 +/- 21% of their @entity0 had their BP controlled. (2) They were mostly in line with guideline recommended BP goals and 96% were aware of the elevated cardiovascular risk of @entity2 , but 41% aimed to reduce BP to acceptable levels only. (3) Physicians indicated that in 41% of @entity0 monotherapy controls BP and 71% would escalate to combination therapy after monotherapy failure. (4) 54% regard @entity2 management as difficult. (5) Physicians estimated that between 60 and 70% of @entity0 know their BP goal but thought that there was still room for improvement of @entity2 management on the @entity0 side. CONCLUSION: Although many effective treatment options for arterial @entity2 exist, BP goal achievement worldwide is suboptimal, leaving @entity0 at an unnecessary cardiovascular risk. An increase in @entity0 ' awareness and compliance together with an increased adherence of physicians to current guidelines should help in reducing the long term cardiovascular consequences of @entity2 .

title: Clinical practice and recent recommendations in XXXX management--reporting a gap in a global survey of 1259 primary care physicians in 17 countries.

answer: @entity2


abstract: Atrial pacing and @entity6 scintigraphy were performed in 72 @entity0 referred for evaluation of @entity4 . @entity3 ( @entity3 ) was present in 63 @entity0 , as documented by cardiac catheterization performed at the same time or within 2 months of atrial pacing. Nine @entity0 had no or insignificant (less than 50% stenosis) @entity3 . The sensitivity of pacing-induced @entity5 for @entity3 was 51%, and was 49% for ST @entity2 . Specificities were 89% and 78%, respectively. A reversible perfusion defect was seen in 54% of @entity0 with @entity3 (specificity 89%), and a fixed defect in 29% (specificity 100%). The sensitivity of an abnormal thallium-201 scan (one or more reversible or fixed defects) was 79% (p less than 0.05 compared to @entity2 ). Combined sensitivity of ST @entity2 and/or an abnormal thallium-201 scan was 87%. There were no significant changes in any of these sensitivities as the number of vessels with @entity3 increased. @entity6 scintigraphy correctly identified 11 of 19 (58%) @entity0 with @entity1 as having @entity3 in only one vessel, but underestimated the extent of disease in all but a few @entity0 with multivessel disease. The sensitivity of perfusion imaging to identify lesions in specific vessels ranged from 27% (circumflex) to 57% (right coronary artery). Specificities were 100% for circumflex, 78% for anterior descending, and 83% for right coronary artery lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Atrial pacing and thallium-201 scintigraphy in @entity0 with XXXX : correlation with coronary anatomy.

answer: @entity4


abstract: Atrial pacing and @entity6 scintigraphy were performed in 72 @entity0 referred for evaluation of @entity4 . @entity3 ( @entity3 ) was present in 63 @entity0 , as documented by cardiac catheterization performed at the same time or within 2 months of atrial pacing. Nine @entity0 had no or insignificant (less than 50% stenosis) @entity3 . The sensitivity of pacing-induced @entity5 for @entity3 was 51%, and was 49% for ST @entity2 . Specificities were 89% and 78%, respectively. A reversible perfusion defect was seen in 54% of @entity0 with @entity3 (specificity 89%), and a fixed defect in 29% (specificity 100%). The sensitivity of an abnormal thallium-201 scan (one or more reversible or fixed defects) was 79% (p less than 0.05 compared to @entity2 ). Combined sensitivity of ST @entity2 and/or an abnormal thallium-201 scan was 87%. There were no significant changes in any of these sensitivities as the number of vessels with @entity3 increased. @entity6 scintigraphy correctly identified 11 of 19 (58%) @entity0 with @entity1 as having @entity3 in only one vessel, but underestimated the extent of disease in all but a few @entity0 with multivessel disease. The sensitivity of perfusion imaging to identify lesions in specific vessels ranged from 27% (circumflex) to 57% (right coronary artery). Specificities were 100% for circumflex, 78% for anterior descending, and 83% for right coronary artery lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Atrial pacing and thallium-201 scintigraphy in XXXX with @entity4 : correlation with coronary anatomy.

answer: @entity0


abstract: Since 1981, a total of 729 ileal pouch-anal anastomoses have been performed at the Mayo Clinic-affiliated hospitals. Three hundred fifty-four were in @entity0 . Twenty of these @entity0 subsequently had at least one successful pregnancy and delivery. Eleven deliveries were vaginal with episiotomy, and nine were cesarean sections. No maternal @entity1 occurred. One @entity0 died of @entity4 . The frequency of nocturnal stooling increased in the ileal pouch-anal @entity2 @entity0 during pregnancy (P less than .01), and the increase persisted for three months after delivery (P less than .05). In contrast, the frequency of daytime stools, the incidence of @entity3 , the consistency of the stool, and the development of perineal seepage or skin irritation were not greatly altered by pregnancy or delivery. Moreover, postpartum pouch function was not influenced by the type of delivery (vaginal vs. cesarean section). In conclusion, pregnancy and delivery are safe in @entity0 with the ileal pouch-anal @entity2 , but they lead to more frequent nocturnal stools. The type of delivery (vaginal vs. cesarean section) does not influence pouch functional outcome.

title: The effect of pregnancy and delivery on the ileal pouch-anal XXXX functions.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: The Oxfordshire @entity1 Project (OCSP) devised a simple classification for acute @entity1 based on clinical features only, which is of value in predicting prognosis. We investigated whether the pattern of @entity7 is related to the clinical syndrome. METHODS: @entity0 with acute @entity2 were classified by a @entity1 physician as having total or partial anterior circulation @entity6 ( @entity9 or PACI, respectively), @entity6 ( @entity6 ), or posterior circulation @entity6 (POCI). Color-coded power transcranial Doppler was done whenever possible. Intracranial arterial velocities were compared in the 4 subtypes of @entity2 after adjustment for age and time to transcranial Doppler. RESULTS: Middle cerebral artery velocity was abnormal ( @entity4 , reduced velocity, @entity3 , or focal @entity5 ) in 38 of 69 TACIs (55%), 50 of 171 PACIs (29%), and 20 of 236 LACIs or POCIs (8%) (P<0.001). Velocity in the A1 segment of the anterior cerebral artery was reversed in 12 of 69 TACIs (17%), 20 of 171 PACIs (12%), and 8 of 236 LACIs or POCIs (3%) (P<0.001). Basilar artery velocity was abnormal in 8 of 121 POCIs (7%) compared with 5 of 355 (1%) of the other subtypes (P=0.005). Vertebral artery velocity was abnormal (reduced velocity, @entity3 , @entity5 ) in 20 of 121 POCIs (17%) compared with 20 of 355 others (6%) (P=0.01). CONCLUSIONS: Intracranial @entity8 were related to OCSP clinical subtype. Therefore, it is possible to stratify @entity0 according to OCSP classification in trials of new treatments in which treatment effectiveness may depend on the underlying pattern of arterial pathology and before any arterial imaging is available.

title: Relationship between pattern of intracranial @entity8 on transcranial doppler and Oxfordshire XXXX Project clinical classification of @entity2 .

answer: @entity1


abstract: BACKGROUND AND PURPOSE: The Oxfordshire @entity1 Project (OCSP) devised a simple classification for acute @entity1 based on clinical features only, which is of value in predicting prognosis. We investigated whether the pattern of @entity7 is related to the clinical syndrome. METHODS: @entity0 with acute @entity2 were classified by a @entity1 physician as having total or partial anterior circulation @entity6 ( @entity9 or PACI, respectively), @entity6 ( @entity6 ), or posterior circulation @entity6 (POCI). Color-coded power transcranial Doppler was done whenever possible. Intracranial arterial velocities were compared in the 4 subtypes of @entity2 after adjustment for age and time to transcranial Doppler. RESULTS: Middle cerebral artery velocity was abnormal ( @entity4 , reduced velocity, @entity3 , or focal @entity5 ) in 38 of 69 TACIs (55%), 50 of 171 PACIs (29%), and 20 of 236 LACIs or POCIs (8%) (P<0.001). Velocity in the A1 segment of the anterior cerebral artery was reversed in 12 of 69 TACIs (17%), 20 of 171 PACIs (12%), and 8 of 236 LACIs or POCIs (3%) (P<0.001). Basilar artery velocity was abnormal in 8 of 121 POCIs (7%) compared with 5 of 355 (1%) of the other subtypes (P=0.005). Vertebral artery velocity was abnormal (reduced velocity, @entity3 , @entity5 ) in 20 of 121 POCIs (17%) compared with 20 of 355 others (6%) (P=0.01). CONCLUSIONS: Intracranial @entity8 were related to OCSP clinical subtype. Therefore, it is possible to stratify @entity0 according to OCSP classification in trials of new treatments in which treatment effectiveness may depend on the underlying pattern of arterial pathology and before any arterial imaging is available.

title: Relationship between pattern of intracranial XXXX on transcranial doppler and Oxfordshire @entity1 Project clinical classification of @entity2 .

answer: @entity8


abstract: BACKGROUND AND PURPOSE: The Oxfordshire @entity1 Project (OCSP) devised a simple classification for acute @entity1 based on clinical features only, which is of value in predicting prognosis. We investigated whether the pattern of @entity7 is related to the clinical syndrome. METHODS: @entity0 with acute @entity2 were classified by a @entity1 physician as having total or partial anterior circulation @entity6 ( @entity9 or PACI, respectively), @entity6 ( @entity6 ), or posterior circulation @entity6 (POCI). Color-coded power transcranial Doppler was done whenever possible. Intracranial arterial velocities were compared in the 4 subtypes of @entity2 after adjustment for age and time to transcranial Doppler. RESULTS: Middle cerebral artery velocity was abnormal ( @entity4 , reduced velocity, @entity3 , or focal @entity5 ) in 38 of 69 TACIs (55%), 50 of 171 PACIs (29%), and 20 of 236 LACIs or POCIs (8%) (P<0.001). Velocity in the A1 segment of the anterior cerebral artery was reversed in 12 of 69 TACIs (17%), 20 of 171 PACIs (12%), and 8 of 236 LACIs or POCIs (3%) (P<0.001). Basilar artery velocity was abnormal in 8 of 121 POCIs (7%) compared with 5 of 355 (1%) of the other subtypes (P=0.005). Vertebral artery velocity was abnormal (reduced velocity, @entity3 , @entity5 ) in 20 of 121 POCIs (17%) compared with 20 of 355 others (6%) (P=0.01). CONCLUSIONS: Intracranial @entity8 were related to OCSP clinical subtype. Therefore, it is possible to stratify @entity0 according to OCSP classification in trials of new treatments in which treatment effectiveness may depend on the underlying pattern of arterial pathology and before any arterial imaging is available.

title: Relationship between pattern of intracranial @entity8 on transcranial doppler and Oxfordshire @entity1 Project clinical classification of XXXX .

answer: @entity2


abstract: BACKGROUND: Laparoscopic cholecystectomy is the treatment of choice for symptomatic @entity6 . @entity2 , however, can prolong hospital stay and lead to increased morbidity. In the context of a multimodal approach to @entity4 , intraperitoneal local anesthetic administration optimizes @entity4 and facilitates early postoperative recovery, and it may be associated with a decreased risk of side effects. METHODS: A total of 71 @entity0 was randomized to receive either intraperitoneal analgesic ( @entity9 group) or not (controls). At the completion of cholecystectomy, 10 mL of @entity5 0.5% were infused intraperitoneally in the @entity9 group and 8 h postoperatively, whereas in the controls, 10 mL of 0.9% @entity3 were administered in the corresponding points of time. Differences in @entity1 scores between groups were the primary endpoints. Opioid consumption and adverse effects were the secondary endpoints. RESULTS: The 2 groups were homogenous in respect to age, sex, body mass index (BMI), and duration of operation. No conversion, complication, or mortality was recorded. The @entity9 group had a lesser visual analog scale score at rest and at movement compared with controls at all points of time measured. Moreover, @entity7 consumption in the recovery room was significantly greater in the control group, and the consumption of @entity8 and the percentage of the @entity0 that requested rescue @entity4 in the ward was significantly greater in the control group. Local analgesic intraperitoneal injection as well as @entity10 for postoperative @entity4 had no significant adverse effects. CONCLUSION: Our study showed that 2 separate doses of intraperitoneally administered @entity5 significantly decreased @entity2 and the need for opioids compared with placebo. This technique is simple, safe, and without adverse effects.

title: Repeated intraperitoneal instillation of @entity5 for the management of XXXX after laparoscopic cholecystectomy.

answer: @entity1


abstract: BACKGROUND: Laparoscopic cholecystectomy is the treatment of choice for symptomatic @entity6 . @entity2 , however, can prolong hospital stay and lead to increased morbidity. In the context of a multimodal approach to @entity4 , intraperitoneal local anesthetic administration optimizes @entity4 and facilitates early postoperative recovery, and it may be associated with a decreased risk of side effects. METHODS: A total of 71 @entity0 was randomized to receive either intraperitoneal analgesic ( @entity9 group) or not (controls). At the completion of cholecystectomy, 10 mL of @entity5 0.5% were infused intraperitoneally in the @entity9 group and 8 h postoperatively, whereas in the controls, 10 mL of 0.9% @entity3 were administered in the corresponding points of time. Differences in @entity1 scores between groups were the primary endpoints. Opioid consumption and adverse effects were the secondary endpoints. RESULTS: The 2 groups were homogenous in respect to age, sex, body mass index (BMI), and duration of operation. No conversion, complication, or mortality was recorded. The @entity9 group had a lesser visual analog scale score at rest and at movement compared with controls at all points of time measured. Moreover, @entity7 consumption in the recovery room was significantly greater in the control group, and the consumption of @entity8 and the percentage of the @entity0 that requested rescue @entity4 in the ward was significantly greater in the control group. Local analgesic intraperitoneal injection as well as @entity10 for postoperative @entity4 had no significant adverse effects. CONCLUSION: Our study showed that 2 separate doses of intraperitoneally administered @entity5 significantly decreased @entity2 and the need for opioids compared with placebo. This technique is simple, safe, and without adverse effects.

title: Repeated intraperitoneal instillation of XXXX for the management of @entity1 after laparoscopic cholecystectomy.

answer: @entity5


abstract: Basiliximab induction treatment has been shown to reduce the incidence of acute rejection episodes without the secondary side effects observed with antilymphocyte polyclonal antibodies. We analyzed our experience with basiliximab induction associated with @entity3 -based immunosuppression among low-immunological risk renal transplant recipients. We retrospectively analyzed 55 renal transplantation @entity0 of low inmunological risk who received organs from donors younger than 55 years. We compared a group of 21 @entity0 (38.9%; group 1) treated with basiliximab (Simulect, Novartis, Basel, Switzerland) with 33 @entity0 (61.1%; group 2) without induction. The @entity0 groups did not differ in recipient age (46.39 +/- 11.1 in group 1 vs 41.82 +/- 11.02 years in group 2; P = .25), donor age (36.71 +/- 14.72 vs 35.09 +/- 14.63 years; P = .69), or recipient and donor gender. No differences were observed in dose or @entity3 levels during follow-up. The incidences of delayed graft function (DGF; 28.6% vs 28.1%; P = .97) and of acute rejection episodes (9.5% vs 15.6%; P = .52) were similar in both groups. Serum @entity2 and proteinuria levels (P > .05) and hospital admissions due to @entity1 (36.4 vs 35.7%; P = .97) were also similar in both groups. At 1 year graft survival rates were 92% and 96% (P = .97) in groups 1 and 2, respectively. Considering our findings and the costs of basiliximab treatment, we conclude that routine administration of basiliximab cannot be justified in young, low-immunological risk transplant recipients undergoing @entity3 -based immunosuppression.

title: Use of basiliximab induction in low-immunological risk renal transplant recipients receiving XXXX -based immunosuppression.

answer: @entity3


abstract: BACKGROUND: Decreased sexual interest and function both occur as a consequence of antidepressant medication use, and are especially associated with @entity4 reuptake inhibitors (SRIs). However, few investigators have reported the base rate for disturbances in sexual desire, arousal and orgasm or ejaculation in @entity0 with @entity2 ( @entity2 ) prior to antidepressant treatment. The purpose of this report is to define the frequency of @entity1 ( @entity1 ) in 134 @entity0 with @entity2 and examine the relationship between @entity1 and demographic, clinical and personality variables. METHOD: A consecutive series of 55 male and 79 female @entity2 @entity0 diagnosed by @entity5 -DSM IV assessment completed a series of psychometric measures including a Sexual Function Questionnaire, which asked about change in sexual interest and function as well as sexual activity during the preceding month. RESULTS: Only 50% of @entity0 and 75% of @entity0 reported sexual activity during the preceding month. Over 40% of @entity0 and 50% of @entity0 reported decreased sexual interest. Reduced levels of arousal were more common in both @entity0 and @entity0 (40-50%) than ejaculatory or orgasm difficulties (15-20%). In @entity0 , problems with arousal and orgasm correlated with higher @entity3 and lower extraversion. There was no relationship between @entity1 and personality measures in @entity0 . While age at onset of @entity2 and number of prior episodes showed a modest correlation with @entity1 measures, there were no correlations with severity of @entity2 or specific symptoms clusters. LIMITATIONS AND CONCLUSIONS: Although limited by a relatively small sample of drug free @entity0 with @entity2 , and by the absence of a non-depressed comparison sample, these results emphasize the importance of factors beyond specific drug effects in the assessment of antidepressant related @entity1 .

title: @entity1 before antidepressant therapy in XXXX .

answer: @entity2


abstract: BACKGROUND: Decreased sexual interest and function both occur as a consequence of antidepressant medication use, and are especially associated with @entity4 reuptake inhibitors (SRIs). However, few investigators have reported the base rate for disturbances in sexual desire, arousal and orgasm or ejaculation in @entity0 with @entity2 ( @entity2 ) prior to antidepressant treatment. The purpose of this report is to define the frequency of @entity1 ( @entity1 ) in 134 @entity0 with @entity2 and examine the relationship between @entity1 and demographic, clinical and personality variables. METHOD: A consecutive series of 55 male and 79 female @entity2 @entity0 diagnosed by @entity5 -DSM IV assessment completed a series of psychometric measures including a Sexual Function Questionnaire, which asked about change in sexual interest and function as well as sexual activity during the preceding month. RESULTS: Only 50% of @entity0 and 75% of @entity0 reported sexual activity during the preceding month. Over 40% of @entity0 and 50% of @entity0 reported decreased sexual interest. Reduced levels of arousal were more common in both @entity0 and @entity0 (40-50%) than ejaculatory or orgasm difficulties (15-20%). In @entity0 , problems with arousal and orgasm correlated with higher @entity3 and lower extraversion. There was no relationship between @entity1 and personality measures in @entity0 . While age at onset of @entity2 and number of prior episodes showed a modest correlation with @entity1 measures, there were no correlations with severity of @entity2 or specific symptoms clusters. LIMITATIONS AND CONCLUSIONS: Although limited by a relatively small sample of drug free @entity0 with @entity2 , and by the absence of a non-depressed comparison sample, these results emphasize the importance of factors beyond specific drug effects in the assessment of antidepressant related @entity1 .

title: XXXX before antidepressant therapy in @entity2 .

answer: @entity1


abstract: OBJECTIVE: The objective of this study was to perform a retrospective analysis of the clinical evolution and surgical complications comparing @entity1 . METHODS: This review of 48 consecutive pancreas transplantation includes 39 simultaneous kidney and @entity1 (PAK) grafts as well as 2 retransplantations. @entity9 was systemic (n = 29) or portal (n = 19). RESULTS: There were no significant differences in @entity0 , kidney, or pancreas allograft survival rates. There were no significant differences in levels of @entity8 , fasting @entity5 , C-peptide, @entity2 , and homeostatic model assessment (HOMA) of beta cells, namely HOMA-s and HOMA-IR index. HbA1c was lower at 6 months and 1 year in the PE group (P < .05). Twenty-two @entity0 displayed @entity3 at a mean time of presentation of 12.8 days. All of these @entity0 but 2 needed relaparotomy. The other two were treated either conservatively (1 enteric @entity4 ) or by interventional radiology ( @entity10 ). There were 10 graft losses, 5 in each group, due to @entity6 , @entity7 , and enteric fistulae. CONCLUSION: Early graft losses were related to @entity7 and @entity6 . Intermediate-term endocrine function was similar in both groups.

title: XXXX and outcomes.

answer: @entity1


abstract: Subtotal gastrectomy is considered the preferred treatment for @entity4 with antral location. The aim of this study was to assess the incidence of @entity2 and late functional results in @entity0 who underwent subtotal gastrectomy with Billroth II reconstruction for primary @entity4 . The results of 310 @entity0 were analyzed with regard to @entity2 and @entity1 rates. Functional results as they relate to the gastric resection were evaluated in 195 disease-free @entity0 . Of the 310 @entity0 , 77 developed @entity2 (24.8%) and 13 consequently died (in-hospital mortality: 4.2%). Although infrequent (6 cases, 1.9%), @entity5 was the most serious complication (4 cases died during the postoperative phase). Considering functional results, @entity3 continued for the first trimester after surgery, after which it stabilized. @entity6 was rarely observed; early after the operation the majority of @entity0 were consuming a normal diet and regularly consumed less than five meals per day (83.6%). @entity7 was uncommon and usually resolved within one year (12.3% at three months, 9.5% after one year, 5.2% after two years). On the other hand, postprandial abdominal fullness was frequently observed (43.1% at three months, 36.1% after one year, 21.3% after three years, and 16.5% after five years). Billroth II reconstruction after subtotal gastrectomy is associated with a limited risk of anastomotic complications. @entity5 , although infrequent, is a life-threatening complaint and requires prompt recognition and aggressive surgical treatment. The incidence of late complications was low and the majority of @entity0 recovered from them within one year after surgery, although the occurrence of postprandial abdominal fullness was not completely irrelevant.

title: @entity2 and functional results after subtotal gastrectomy with Billroth II reconstruction for primary XXXX .

answer: @entity4


abstract: Subtotal gastrectomy is considered the preferred treatment for @entity4 with antral location. The aim of this study was to assess the incidence of @entity2 and late functional results in @entity0 who underwent subtotal gastrectomy with Billroth II reconstruction for primary @entity4 . The results of 310 @entity0 were analyzed with regard to @entity2 and @entity1 rates. Functional results as they relate to the gastric resection were evaluated in 195 disease-free @entity0 . Of the 310 @entity0 , 77 developed @entity2 (24.8%) and 13 consequently died (in-hospital mortality: 4.2%). Although infrequent (6 cases, 1.9%), @entity5 was the most serious complication (4 cases died during the postoperative phase). Considering functional results, @entity3 continued for the first trimester after surgery, after which it stabilized. @entity6 was rarely observed; early after the operation the majority of @entity0 were consuming a normal diet and regularly consumed less than five meals per day (83.6%). @entity7 was uncommon and usually resolved within one year (12.3% at three months, 9.5% after one year, 5.2% after two years). On the other hand, postprandial abdominal fullness was frequently observed (43.1% at three months, 36.1% after one year, 21.3% after three years, and 16.5% after five years). Billroth II reconstruction after subtotal gastrectomy is associated with a limited risk of anastomotic complications. @entity5 , although infrequent, is a life-threatening complaint and requires prompt recognition and aggressive surgical treatment. The incidence of late complications was low and the majority of @entity0 recovered from them within one year after surgery, although the occurrence of postprandial abdominal fullness was not completely irrelevant.

title: XXXX and functional results after subtotal gastrectomy with Billroth II reconstruction for primary @entity4 .

answer: @entity2


abstract: BACKGROUND: Asthma exacerbations can be provoked by many triggers such as allergens, @entity3 . The relative importance of these has not been prospectively documented in a case-control study. OBJECTIVE: To assess the relative importance of colds and other nonclimatic historical triggers of @entity2 exacerbations. METHODS: One hundred and nineteen adults and @entity0 with @entity2 in two Canadian cities participated in a one-year study of the role of exacerbating factors in @entity2 . Among these, 36 pairs (21 adult, 15 @entity0 ) completed the case-control study. @entity0 were considered cases if they developed an acute @entity2 exacerbation and notified the centre within 24 h to allow the completion of a questionnaire and viral studies (cultures of nasopharyngeal swabs and serology). Control @entity0 with @entity2 were matched for sex, age and area of residence, had no exacerbation during the preceding four weeks and participated within 48 h of the case @entity0 . RESULTS: Case @entity0 versus control @entity0 had a mean age of 22 years versus 20 years, 50% versus 55% were male, and 92% versus 86% had at least one positive aeroallergen skin test. Cases were more likely to have taken regular inhaled @entity1 (63% versus 33%, P<0.002). Cases were more likely to report the following within the previous week: fever (P<0.001), sore throat (P<0.001), increase in nasal symptoms (P<0.01), increased dust exposure (P<0. 05), exposure to others with a cold (P<0.001) and, over the previous year, increased passive smoke exposure (P<0.05). Viral cultures and paired serology were negative. CONCLUSIONS: Symptomatic colds were the most common trigger of @entity2 exacerbations in the winter and spring, while a transient increase in dust exposure was also identified as a significant trigger. The association with chronic, passive smoke exposure and the use of inhaled costicosteroid medications likely reflected less stable pre-study @entity2 in those with exacerbations.

title: A case-control study of the role of cold symptoms and other historical triggering factors in XXXX exacerbations.

answer: @entity2


abstract: OBJECTIVE: We determined the prognostic value of @entity2 (FDG) positron emission tomography (PET) for @entity0 with treated @entity1 . MATERIALS AND METHODS: We examined @entity0 who underwent FDG PET after first-line treatment for @entity3 . FDG PET results were correlated with survival rates to determine whether FDG PET findings were predictive of outcomes. RESULTS: After initial therapy, 113 @entity0 with @entity3 underwent FDG PET. One hundred @entity0 had positive FDG PET results and a median survival of 12 months (95% confidence interval, 9.2-15.4). Thirteen @entity0 had negative FDG PET results, and 11 (85%) of these @entity0 are still living at a median follow-up of 34 months. The difference in survival for @entity0 with positive and negative FDG PET results was statistically significant (p = 0.002). CONCLUSION: FDG PET has prognostic value and strongly correlates with survival rates of @entity0 with treated @entity1 . @entity0 with positive FDG PET results have a significantly worse prognosis than @entity0 with negative results. Additionally, FDG PET may be helpful in guiding therapeutic treatments.

title: Prognostic value of thoracic FDG PET imaging after treatment for XXXX .

answer: @entity3


abstract: Characterization of endogenous synthesis of prolactin ( @entity2 ) proteins and their cellular localization in labial salivary glands of @entity0 with @entity3 ( @entity3 ) were achieved. @entity2 , @entity5 ( @entity5 ), and @entity4 protein were detected by immunohistochemistry. In situ prolactin synthesis was investigated in controls and @entity3 @entity0 by ex vivo incubation of minor salivary glands biopsies and immunoprecipitation assay. Increased @entity2 -immunoreactivity was found in cytoplasmic acinar epithelial cells in @entity3 @entity0 compared with normal subjects. @entity5 was distributed only in ductal epithelial cells in which @entity4 protein (a @entity5 -associated protein) was also present. @entity2 , @entity5 , or @entity4 -immunoreactivity was not detected in infiltrating mononuclear cells. Immunoprecipitation demonstrated that @entity2 synthesis occurred in minor salivary glands with increased synthesis of two distinct @entity2 -like proteins (one major band at 60 kDa and a minor at 16 kDa) in @entity3 glands compared with normal glands. Expression of @entity2 gene was demonstrated in @entity3 salivary glands using RT-PCR. A positive correlation was found between the presence of @entity2 -like proteins in acinar epithelial cells of @entity3 @entity0 and clinical extraglandular manifestations. The presence of anti-Ro and anti-La antibodies also positively correlated with a higher percentage of @entity2 in acinar epithelial cells. In conclusion, @entity2 -like proteins are synthetized and overexpressed in glandular epithelial cells of labial salivary glands from @entity3 @entity0 and correlate with the @entity1 .

title: Big prolactin 60 kDa is overexpressed in salivary glandular epithelial cells from XXXX with Sj  gren's syndrome.

answer: @entity0


abstract: We aimed at describing the epidemiology of femur @entity2 in elderly hospitalized for femur @entity2 in Lazio (Italy), and evaluating the association between @entity0 's and hospital characteristics on in-hospital mortality. We conducted a population- and hospital-based study (Lazio region: 5.233.233 inhabitants) among @entity0 65+ years aged. SOURCE OF DATA: regional hospital register 2002-2003; ICD-9-CM codes for @entity0 ' selection 820 e 821. Direct standardization (rate x 1000) and logistic regression analysis (OR, 95% CI) were performed. Overall hospitalization rate in elderly was 7.5%o (10.l%o females vs. 3.9%0 males). 12.033 @entity0 with femur @entity2 were enrolled in the study period; 21,6% were not treated surgically: in comparison with those who underwent surgery, they were males, residents out of Rome, older and with worst health status. In-hospital mortality rate was 7,97%. In-hospital mortality determinants were: male gender (OR=0.56), older age (85+, OR=3.30), living out of Rome (OR=0.50), comorbidities (Charlson 'index 3: OR=4.44), "others and unspecified parts of femur" as site of @entity2 (OR=1.84), admission to a private hospital (OR=O. 79) and a surgical treatment (OR=0.20). In conclusion, this study showed the effect of selected individual characteristics on in hospital mortality and suggested a role of early surgical treatment and access to private sector. Regional hospital information systems represent useful tools to address epidemiological impact of @entity1 and its health care resources utilization.

title: [Epidemiology of femur XXXX and characteristics of hospital care in Lazio].

answer: @entity2


abstract: The development of @entity0 peripheral hindlimb and lumbar dorsal horn innervation by different subpopulations of dorsal root ganglion cells was investigated from embryonic day (E)13 to birth by using immunostaining. Antibodies to @entity2 , @entity4 , and @entity5 were used as pan-neuronal markers, RT97 for A fibres; @entity3 ( @entity3 ), @entity1 , and the lectin IB4 for small A and C fibres. Size frequency analysis showed that RT97 is a selective marker for large A cells at E18. Although both A and C fibres enter the hindlimb at E13-14, A fibres are the first to innervate the skin and dominate over small fibre innervation until later fetal life. @entity3 expression in sensory axons appears at E19 and in all regions simultaneously, suggesting expression in existing fibres. All sensory terminals grow transiently to the skin surface before retracting subepidermally at late embryonic stages. The development of peripheral and central innervation by the same subpopulations of sensory neurons was compared. The entry of A fibre terminals into the lumbar dorsal horn at E14 coincided with hindlimb skin innervation. In contrast, C fibres were not detected in the dorsal horn until E18, 4 days after peripheral innervation. @entity3 expression appears in both spinal cord and hindlimb targets at E19. IB4 binding in the central terminals began at E18 but was never observed in embryonic peripheral axons. These results demonstrate that in fetal skin, A fibre innervation dominates over C fibres. In addition, alathough peripheral and central innervation by A fibres coincide, this is not true for C fibres, suggesting that central target factors may control C fibre terminal growth within the dorsal horn.

title: Development of peripheral hindlimb and central spinal cord innervation by subpopulations of dorsal root ganglion cells in the embryonic XXXX .

answer: @entity0


abstract: OBJECTIVES: The improvement of pre-existing @entity1 after orthotopic liver transplant might be anticipated. However, both the exacerbation of @entity1 and de novo @entity1 after orthotopic liver transplant (despite sufficient allograft immunosuppressive therapy) have been described. MATERIALS AND METHODS: We present a case of @entity2 in a pediatric liver transplant recipient. RESULTS: A 13-year-old @entity0 with cryptogenic liver @entity3 received an orthotopic liver transplant from a deceased donor. Five months later, he presented with watery @entity5 and @entity10 . He was treated with the immunosuppressive agents @entity9 (0.15 mg/kg/d) and @entity7 (20 mg/kg/d). A general physical examination revealed a @entity0 with stable vital signs and without @entity4 . The only positive finding was enlargement of the abdomen without tenderness. Many pus cells and a few red blood cells were detected in the @entity0 's stool, but the results of a stool culture for bacteria were negative. Because of his chronic @entity5 , this @entity0 underwent colonoscopy, which revealed @entity13 , multiple @entity8 , exudate, and pseudopolyps with a diffuse loss of vascularity. Those findings are indicators of @entity11 . The results of histopathologic examination of the colonic mucosa suggested @entity2 . The @entity0 was treated with @entity12 and @entity6 , and a repeat colonoscopy revealed an improvement in his @entity1 . CONCLUSIONS: De novo @entity1 should be considered in @entity0 in whom chronic @entity5 develops after an orthotopic liver transplant. We suggest that colonoscopy and biopsy should always be performed if other causes of @entity5 have been excluded.

title: De novo XXXX after pediatric orthotopic liver transplant: a case report.

answer: @entity1


abstract: A school environmental study of about 20,000 @entity0 from the French department of MAINE and LOIRE (1/100 of French territory and 1/100 of the total population) was made during the summer of 1987 in all the schools of the region. The replies allowed evaluation of: -- The elements of the environment; . urban or rural . type of building . soils . domestic animals (types, lifestyle, large or small, relationship with the @entity0 ). -- The proportion of allergic @entity0 per classroom, types of sickness, suggestions made by parents, eventual @entity1 during class hours. In addition, school teachers were asked to comment on the subject. Their answers showed extreme variety of attitude towards @entity2 , there were those who refuted it, some fully accepted and others who asked for more information so that they could be more help to their students. A prime interest of the study lies in the dialogue between parents, teachers and physicians as the @entity0 spent most of the daytime at school and therefore the quality of the environment is a major factor in infantile @entity2 .

title: [Epidemiologic study of XXXX in the school environment].

answer: @entity2


abstract: A simple reversed-phase high-performance liquid chromatography (HPLC) method with UV detection was developed and validated for the quantitation of @entity3 , a novel @entity2 antifungal agent and its analogs in @entity0 plasma. The method involved a simple precipitation of plasma protein with @entity1 (1:10 ratio). The reconstituted sample after evaporation to dryness was injected onto a HPLC column. @entity3 and its analogs were separated from the matrix components on a symmetry C18 column using an aqueous mobile phase of @entity1 and water with a flow rate of 1 ml min(-1). A step gradient of 40-80% @entity1 eluted all four compounds. The run time was 30 min. The linear range was 0.5 10 microg ml(-1)(r2 > 0.999). The limit of quantitation was 0.5 microg ml(-1). The inter-day precision and accuracy for @entity3 standard concentration were from 1.9 to 8.5% and from 1.4 to +/- 4.40%, respectively. The precision and accuracy of intra-day quality control samples were from 4.6 to 5.2% and from 4.6 to 12%, respectively.

title: High-performance liquid chromatographic analysis of new @entity2 antifungal agent XXXX and its derivatives in plasma.

answer: @entity3


abstract: A simple reversed-phase high-performance liquid chromatography (HPLC) method with UV detection was developed and validated for the quantitation of @entity3 , a novel @entity2 antifungal agent and its analogs in @entity0 plasma. The method involved a simple precipitation of plasma protein with @entity1 (1:10 ratio). The reconstituted sample after evaporation to dryness was injected onto a HPLC column. @entity3 and its analogs were separated from the matrix components on a symmetry C18 column using an aqueous mobile phase of @entity1 and water with a flow rate of 1 ml min(-1). A step gradient of 40-80% @entity1 eluted all four compounds. The run time was 30 min. The linear range was 0.5 10 microg ml(-1)(r2 > 0.999). The limit of quantitation was 0.5 microg ml(-1). The inter-day precision and accuracy for @entity3 standard concentration were from 1.9 to 8.5% and from 1.4 to +/- 4.40%, respectively. The precision and accuracy of intra-day quality control samples were from 4.6 to 5.2% and from 4.6 to 12%, respectively.

title: High-performance liquid chromatographic analysis of new XXXX antifungal agent @entity3 and its derivatives in plasma.

answer: @entity2


abstract: BACKGROUND: @entity2 (>30 mg/day) based on 24 h urine albumin excretion is one of the criteria for @entity3 ( @entity3 ) and a predictor of @entity1 ( @entity1 ). Differences in urine albumin concentration and @entity4 excretion rates between Indo-Asians and other populations may require different threshold values for detection of @entity2 . We compared the use of spot urine albumin concentration and urine albumin to @entity4 excretion ratio for detection of @entity2 in this population. METHODS: A total of 577 subjects aged >or=40 years, 54% of whom were @entity0 , were recruited from the general population in Karachi, Pakistan. Albumin concentration (mg/l) and albumin to @entity4 ratio (mg/g of @entity4 ) were determined in a spot morning urine sample, and @entity2 (30 mg/day or greater) measured in a 24 h urine collected on the subsequent day. RESULTS: The median (25-75 percentile) of urine albumin excretion was 4.8 (3.6-10.3) mg/day: 5.4 (3.7-12.5) mg/day in @entity0 and 4.5 (3.8-8.9) mg/day in @entity0 . The overall prevalence (95% CI) of @entity2 was 11.8% (7.2-12.0%): 14.8% in @entity0 and 9.2% in @entity0 (P = 0.04). The areas under the receiver operator characteristic (ROC) curves for urine albumin concentration were 0.86 (0.82-0.90) and 0.88 (0.84-0.92), respectively, in @entity0 and @entity0 . The areas under the ROC curves for albumin to @entity4 ratio were 0.86 (0.82-0.89) and 0.90 (0.86-0.93), respectively, in @entity0 and @entity0 . For urine albumin concentration, the sensitivity and specificity were 37 and 97%, respectively, in @entity0 and 69 and 94%, respectively, in @entity0 at the conventionally recommended value of 2 mg/dl. The discriminator value of urine albumin concentration identified in the analysis was 0.5 mg/dl in @entity0 (sensitivity of 87% and specificity of 75%) and 1.7 mg/dl in @entity0 (sensitivity of 74% and specificity of 93%). For the albumin to @entity4 ratio, the sensitivity and specificity were 46 and 95%, respectively, in @entity0 and 60 and 97%, respectively, in @entity0 at cut-off value of 30 mg/g. CONCLUSION: Both urine albumin concentration and albumin to @entity4 ratio are acceptable tests for population screening for @entity2 in Indo-Asians. While sensitivities may be suboptimal, particularly in @entity0 , lowering the existing thresholds would compromise specificity. Those who screen positive need evaluation and management of @entity3 and prevention of @entity1 .

title: Use of albumin XXXX ratio and urine albumin concentration as a screening test for @entity2 in an Indo-Asian population.

answer: @entity4


abstract: BACKGROUND: @entity2 (>30 mg/day) based on 24 h urine albumin excretion is one of the criteria for @entity3 ( @entity3 ) and a predictor of @entity1 ( @entity1 ). Differences in urine albumin concentration and @entity4 excretion rates between Indo-Asians and other populations may require different threshold values for detection of @entity2 . We compared the use of spot urine albumin concentration and urine albumin to @entity4 excretion ratio for detection of @entity2 in this population. METHODS: A total of 577 subjects aged >or=40 years, 54% of whom were @entity0 , were recruited from the general population in Karachi, Pakistan. Albumin concentration (mg/l) and albumin to @entity4 ratio (mg/g of @entity4 ) were determined in a spot morning urine sample, and @entity2 (30 mg/day or greater) measured in a 24 h urine collected on the subsequent day. RESULTS: The median (25-75 percentile) of urine albumin excretion was 4.8 (3.6-10.3) mg/day: 5.4 (3.7-12.5) mg/day in @entity0 and 4.5 (3.8-8.9) mg/day in @entity0 . The overall prevalence (95% CI) of @entity2 was 11.8% (7.2-12.0%): 14.8% in @entity0 and 9.2% in @entity0 (P = 0.04). The areas under the receiver operator characteristic (ROC) curves for urine albumin concentration were 0.86 (0.82-0.90) and 0.88 (0.84-0.92), respectively, in @entity0 and @entity0 . The areas under the ROC curves for albumin to @entity4 ratio were 0.86 (0.82-0.89) and 0.90 (0.86-0.93), respectively, in @entity0 and @entity0 . For urine albumin concentration, the sensitivity and specificity were 37 and 97%, respectively, in @entity0 and 69 and 94%, respectively, in @entity0 at the conventionally recommended value of 2 mg/dl. The discriminator value of urine albumin concentration identified in the analysis was 0.5 mg/dl in @entity0 (sensitivity of 87% and specificity of 75%) and 1.7 mg/dl in @entity0 (sensitivity of 74% and specificity of 93%). For the albumin to @entity4 ratio, the sensitivity and specificity were 46 and 95%, respectively, in @entity0 and 60 and 97%, respectively, in @entity0 at cut-off value of 30 mg/g. CONCLUSION: Both urine albumin concentration and albumin to @entity4 ratio are acceptable tests for population screening for @entity2 in Indo-Asians. While sensitivities may be suboptimal, particularly in @entity0 , lowering the existing thresholds would compromise specificity. Those who screen positive need evaluation and management of @entity3 and prevention of @entity1 .

title: Use of albumin @entity4 ratio and urine albumin concentration as a screening test for XXXX in an Indo-Asian population.

answer: @entity2


abstract: OBJECTIVE: Outcome data on the surgical treatment of @entity1 are, in general, based on short-term follow-up (<6-9 months). This examination was undertaken to assess long-term results. METHODS: Forty @entity0 who underwent soft tissue and skeletal surgery were the subjects of this review. Methods of evaluation included polysomnographic variables (respiratory disturbance index [RDI], low oxyhemoglobin desaturation [LSAT]), body mass index, quality-of-life assessments, roentgenographic analysis, and complications. Statistical analysis used the @entity2 .12 system. RESULTS: Thirty-six of 40 @entity0 (90%) showed long-term clinical success. The mean preoperative RDI, nasal continuous positive airway pressure RDI, and long-term RDI were 71.2 +/- 27.0, 7.6 +/- 5.2 and 7.6 +/- 5.1, respectively. The mean preoperative LSAT, nasal continuous positive airway pressure LSAT, and long-term LSAT were 67. 5% +/- 14.8%, 87.1% +/- 3.2%, and 86.3% +/- 3.9%, respectively. The mean follow-up was 50.7 +/- 31.9 months. The @entity0 showed a statistically significant long-term weight gain (P = 0.0002) compared with their 6-month postoperative level (body mass index 31. 4 +/- 6.7 vs 32.2 +/- 6.3). There was a positive correlation with the amount of skeletal advancement and clinical outcome. CONCLUSION: Comprehensive evaluation and surgical treatment can result in successful long-term clinical outcome.

title: XXXX : long-term clinical outcomes.

answer: @entity1


abstract: The aim of this study was to perform a prospective evaluation of the effectiveness of computed tomography (CT)-guided transthoracic fine needle aspiration (TFNA) in the diagnosis of @entity2 and to determine the complication rate of this procedure. A prospective review was conducted of 134 @entity0 who underwent CT-guided TFNA at our center between December 2003 and August 2005. All fine needle aspirations were performed with a 22-gauge single-pass Chiba needle under CT guidance. The biopsies were performed by one pulmonologist. Two hundred twenty two (91%) malignant lesions and 12 (9%) benign lesions were reviewed in the present study. An accurate diagnosis was made in 107 (88%) of the 122 @entity2 and a specific diagnosis was obtained in 42% of the benign lesions. The sensitivity of TFNAs for the detection of @entity1 was 83%, and the overall accuracy of TFNA for diagnosing @entity1 was 84%. Pneumothorax occurred in 22 of the 134 @entity0 (16%). Pneumothorax was more frequently observed in centrally located lesions (p= 0.001). Our results suggest that CT-guided TFNA has a high diagnostic accuracy and an acceptable rate of complications. Moreover, we suggest that the most important factor increasing the risk of pneumothorax is an increase in the depth of aerated lung traversed for sampling.

title: CT-guided transthoracic fine needle aspiration of XXXX : accuracy and complications in 134 cases.

answer: @entity2


abstract: OBJECTIVE: The present study was aimed to enlarge the Italian @entity3 sample analysed for @entity1 gene mutations. METHODS: Genomic DNA from 47 @entity0 , 70 @entity4 @entity0 and 158 controls was extracted from peripheral blood samples according to a standard protocol. The five coding exons (2-6) of the @entity1 gene and the flanking exon-intron boundaries were analysed by direct sequencing. Using ClustalW2 @entity0 @entity1 , protein sequence was aligned with @entity1 protein sequence of different species. RESULTS: A heterozygous @entity6 transition that leads to a change @entity7 was observed in a 75-years-old male @entity0 and in his two affected siblings. A @entity0 's brother had died at 69 years of age after a two-year history of @entity3 . In @entity4 @entity0 no mutations were found. CONCLUSIONS: We describe a further Italian family with @entity5 , in which a variant ( @entity7 ) of the @entity1 gene was identified. Clinical course and phenotypic variability in three affected siblings is presented and relevance for genetic counselling of @entity0 and their families is underlined. At the present state of knowledge, we suggest that the same guidelines established for @entity2 molecular testing could be proposed also for @entity1 analysis in @entity5 .

title: Enlarging clinical spectrum of @entity5 with @entity1 gene mutations: XXXX variant in an Italian family showing phenotypic variability and relevance for genetic counselling.

answer: @entity7


abstract: OBJECTIVE: The present study was aimed to enlarge the Italian @entity3 sample analysed for @entity1 gene mutations. METHODS: Genomic DNA from 47 @entity0 , 70 @entity4 @entity0 and 158 controls was extracted from peripheral blood samples according to a standard protocol. The five coding exons (2-6) of the @entity1 gene and the flanking exon-intron boundaries were analysed by direct sequencing. Using ClustalW2 @entity0 @entity1 , protein sequence was aligned with @entity1 protein sequence of different species. RESULTS: A heterozygous @entity6 transition that leads to a change @entity7 was observed in a 75-years-old male @entity0 and in his two affected siblings. A @entity0 's brother had died at 69 years of age after a two-year history of @entity3 . In @entity4 @entity0 no mutations were found. CONCLUSIONS: We describe a further Italian family with @entity5 , in which a variant ( @entity7 ) of the @entity1 gene was identified. Clinical course and phenotypic variability in three affected siblings is presented and relevance for genetic counselling of @entity0 and their families is underlined. At the present state of knowledge, we suggest that the same guidelines established for @entity2 molecular testing could be proposed also for @entity1 analysis in @entity5 .

title: Enlarging clinical spectrum of @entity5 with XXXX gene mutations: @entity7 variant in an Italian family showing phenotypic variability and relevance for genetic counselling.

answer: @entity1


abstract: OBJECTIVE: The present study was aimed to enlarge the Italian @entity3 sample analysed for @entity1 gene mutations. METHODS: Genomic DNA from 47 @entity0 , 70 @entity4 @entity0 and 158 controls was extracted from peripheral blood samples according to a standard protocol. The five coding exons (2-6) of the @entity1 gene and the flanking exon-intron boundaries were analysed by direct sequencing. Using ClustalW2 @entity0 @entity1 , protein sequence was aligned with @entity1 protein sequence of different species. RESULTS: A heterozygous @entity6 transition that leads to a change @entity7 was observed in a 75-years-old male @entity0 and in his two affected siblings. A @entity0 's brother had died at 69 years of age after a two-year history of @entity3 . In @entity4 @entity0 no mutations were found. CONCLUSIONS: We describe a further Italian family with @entity5 , in which a variant ( @entity7 ) of the @entity1 gene was identified. Clinical course and phenotypic variability in three affected siblings is presented and relevance for genetic counselling of @entity0 and their families is underlined. At the present state of knowledge, we suggest that the same guidelines established for @entity2 molecular testing could be proposed also for @entity1 analysis in @entity5 .

title: Enlarging clinical spectrum of XXXX with @entity1 gene mutations: @entity7 variant in an Italian family showing phenotypic variability and relevance for genetic counselling.

answer: @entity5


abstract: The 17-kDa antigen of @entity3 has previously been shown to elicit a strong humoral immune response in @entity0 with @entity4 ( @entity4 ) and to be useful in screening human serum samples for @entity4 . In this study, PCR amplification of genes homologous to the 17-kDa antigen gene of @entity3 was performed using genomic DNAs from several species of @entity6 , including the currently recognized @entity0 pathogens. Amplicons of similar size were demonstrated using the following chromosomal DNA templates: @entity3 (two strains), @entity6 (two strains), B. elizabethae, @entity7 , @entity2 . berkhoffii. No evidence of a @entity5 homolog of the 17-kDa antigen gene was obtained using multiple primer pairs. DNA sequencing revealed open reading frames capable of coding for proteins with sizes similar to that of the 17-kDa antigen of @entity3 in all of the amplicons; however, extensive sequence divergence across the genus was noted. Cloning of the amplified products into pUC19 resulted in recombinants that directed synthesis of homologs of the 17-kDa protein. Immunoblot analysis using @entity0 sera from @entity4 cases demonstrated very little cross-reactivity among different species for this protein. In contrast, immunoblots using rabbit serum raised to the recombinant B. henselae antigen showed extensive cross-reactivity with the proteins of other @entity6 species. The data suggest that the use of the 17-kDa antigen as a serologic reagent may allow the development of more specific diagnostic assays. Furthermore, the @entity1 sequences from the various versions of the 17-kDa antigen gene should be useful for rapid identification of @entity6 at the species level.

title: Conservation of the 17-kilodalton antigen gene within the genus XXXX .

answer: @entity6


abstract: We report 22 examples of an unusual and distinctive benign @entity3 arising exclusively from lymph nodes of the groin. The @entity2 , which presents clinically as a swelling, is composed of spindled cells arranged in solid sheets or short, vaguely palisaded fascicles similar to a @entity4 . The spindled cells blend gradually with large mats of eosinophilic material that appear as thick bands, @entity7 , or circular profiles, depending on the plane of section. These eosinophilic structures, which represent a highly characteristic feature of the @entity2 , contain deeply eosinophilic, collagen-rich cores surrounded by a weakly eosinophilic, actin-rich cuff. The actin within these eosinophilic structures is derived by coalescence of intracellular actin globules extruded from neighboring cells. In all cases, a thin, compressed rim of normal lymph node was identified. Immunohistochemical analysis indicates that the cells express actin but lack S-100 protein, @entity6 , @entity5 , keratin, and epithelial membrane antigen. Delicate, linear striations were identified in only two cases by conventional histochemical techniques. The foregoing features suggest that the @entity2 is related to a myofibroblast or a specialized smooth-muscle cell. These @entity2 , therefore, probably arise from smooth-muscle-like cells, which are normally present in some lymph node capsules or stroma. Follow-up information on 17 @entity0 indicated that all are alive and well without any evidence of recurrence or @entity1 .

title: Palisaded myofibroblastoma. A benign XXXX of lymph node.

answer: @entity3


abstract: PURPOSE: To evaluate the healing response at the flap interface in corneas with @entity9 that required penetrating keratoplasty (PK). METHODS: Corneas of five @entity0 who developed @entity7 after LASIK (range: 2.5 to 5 years postoperative) were collected after corneal transplant surgery. The corneas were bisected and processed for conventional histologic analysis and immunofluorescence. RESULTS: Light microscopy showed a hypocellular @entity5 at the wound margin compared with the adjacent @entity7 in all eyes. All corneas had positive staining for @entity8 ( @entity8 ), a myofibroblast marker. In one eye, alpha- @entity8 cells were located in the @entity5 region in the area of the semicircular ring of haze along the margin of the LASIK flap corresponding to an area of @entity6 . In all other eyes, alpha- @entity8 positive cells were fewer and mainly located in the superficial stroma under the epithelial wound margin surface. Type III collagen was minimal or absent in the central zone and wound margin of all corneas except for the @entity2 with @entity6 present in the hypercellular @entity5 region. Chondroitin @entity3 was stronger in the periphery of the flap wound coinciding with a higher presence of alpha- @entity8 -positive cells in that region. Positive staining for @entity4 ( @entity4 ) in the paracentral wound margin scar was seen. CONCLUSIONS: A wound-healing process characterized by absence of significant @entity1 and myofibroblasts at the wound edge in the flap interface was noted in all keratectatic eyes. However, changes in the composition of collagen and the presence of @entity4 at the wound edge several years after LASIK indicates active wound remodeling that may explain the ongoing loss of tissue and tendency of the @entity2 to bulge.

title: Immunohistological evaluation of the healing response at the flap interface in @entity0 with XXXX requiring penetrating keratoplasty.

answer: @entity9


abstract: PURPOSE: To evaluate the healing response at the flap interface in corneas with @entity9 that required penetrating keratoplasty (PK). METHODS: Corneas of five @entity0 who developed @entity7 after LASIK (range: 2.5 to 5 years postoperative) were collected after corneal transplant surgery. The corneas were bisected and processed for conventional histologic analysis and immunofluorescence. RESULTS: Light microscopy showed a hypocellular @entity5 at the wound margin compared with the adjacent @entity7 in all eyes. All corneas had positive staining for @entity8 ( @entity8 ), a myofibroblast marker. In one eye, alpha- @entity8 cells were located in the @entity5 region in the area of the semicircular ring of haze along the margin of the LASIK flap corresponding to an area of @entity6 . In all other eyes, alpha- @entity8 positive cells were fewer and mainly located in the superficial stroma under the epithelial wound margin surface. Type III collagen was minimal or absent in the central zone and wound margin of all corneas except for the @entity2 with @entity6 present in the hypercellular @entity5 region. Chondroitin @entity3 was stronger in the periphery of the flap wound coinciding with a higher presence of alpha- @entity8 -positive cells in that region. Positive staining for @entity4 ( @entity4 ) in the paracentral wound margin scar was seen. CONCLUSIONS: A wound-healing process characterized by absence of significant @entity1 and myofibroblasts at the wound edge in the flap interface was noted in all keratectatic eyes. However, changes in the composition of collagen and the presence of @entity4 at the wound edge several years after LASIK indicates active wound remodeling that may explain the ongoing loss of tissue and tendency of the @entity2 to bulge.

title: Immunohistological evaluation of the healing response at the flap interface in XXXX with @entity9 requiring penetrating keratoplasty.

answer: @entity0


abstract: 1. Characterization of P2X receptors on neurons of @entity1 superior cervical ganglion (SCG) has been carried out using a whole-cell voltage-clamp technique. 2. Application of @entity2 and @entity3 ( @entity3 ) produced fast activating inward currents, which desensitized slowly. The maximum response to @entity3 was 36 +/- 23 % (range 0.1-100 %) of that evoked by @entity2 in the same cell. 3. Co-application of @entity3 (300 microM) with @entity2 (300 microM) produced a response that was 97 +/- 1 % of that given by @entity2 alone. Following desensitization with @entity3 , the decrease in response to @entity2 was equal to the absolute reduction in response to @entity3 in the same cell. 4. The concentration-response curve for @entity3 had an EC50 of 42 microM and a Hill coefficient of 1.17. For cells where the ratio of @entity3 / @entity2 currents at 100 microM was < 0.1, the @entity2 concentration-response curve had an EC50 of 56 microM and a Hill coefficient of 1.95. However, in cells where the ratio was > 0.7, the curve had an EC50 of 60 microM and a Hill coefficient of 0.97. 5. The response to 100 microM @entity3 was inhibited by 2' (or 3')-O-trinitrophenyl- @entity2 ( @entity4 - @entity2 ) with an IC50 of 70 nM. However, on cells where the ratio of @entity3 / @entity2 currents was < 0.1, @entity2 was inhibited by TNP- @entity2 with an IC50 of 522 nM. 6. Immunohistochemical staining with antibodies raised against @entity0 @entity5 and @entity6 epitopes suggested that both subunits were expressed by @entity1 SCG neurons. 7. We conclude that varying proportions of two distinct P2X receptors coexist on the cell bodies of individual @entity1 SCG neurons, which may correspond to homomeric @entity5 and heteromeric @entity5 /3 receptors.

title: XXXX sympathetic neurons express varying proportions of two distinct P2X receptors.

answer: @entity1


abstract: OBJECTIVE: To determine the effects of 16 weeks of resistive training alone (RT) and with @entity2 (RT+WL) on insulin action, plasma leptin concentrations and leptin's relationship to beta-cell sensitivity to @entity3 , resting metabolic rate (RMR), and plasma @entity7 in older @entity0 . SUBJECTS: Fifteen obese postmenopausal @entity0 aged 50-69 y. MEASUREMENTS: Body composition (by dual-energy X-ray absorptiometry), RMR (by indirect calorimetry), insulin action (by 2 h @entity6 clamps; 7.9 mmol/l above basal plasma @entity3 levels), plasma leptin and insulin (by RIA), and plasma @entity7 (by enzymatic methods). RESULTS: RT and RT+WL resulted in significant improvements in muscular strength (P<0.01) with no changes in maximal @entity1 consumption. Body weight, fat mass and percent body fat did not change with RT, but decreased with RT+WL (P<0.001). Fat-free mass and RMR increased after training when both groups were combined (P<0.05). The insulin response during the last 20 min of the 2 h @entity6 clamps decreased 16% after RT (P=0.05), 43% after RT+WL (P<0.05), and 29% in the entire group (P<0. 01) without any changes in @entity3 utilization. Plasma leptin levels did not change after RT, but decreased by 36% after RT+WL (P<0.05). Baseline leptin levels correlated with body weight (r=0.68, P<0.01), body fat mass (r=0.77, P<0.001), and RMR (kcal/d; (r=0.69, P<0.005), but not with baseline @entity4 or @entity5 levels. Plasma leptin levels correlated with basal insulin (r=0.73, P<0.005), and approached significance with the 0-10 min and 100-120 min insulin response to @entity8 before training (both r=0.51, P=0.07). In the entire group, the change in insulin response from 100-120 min during the clamp correlated with the change in leptin levels (r=0.60, P<0.05), but this was not independent of changes in fat mass. CONCLUSIONS: Although changes in leptin levels were not related to changes in RMR or plasma @entity7 after RT with and without @entity2 , the increase in insulin action after training and @entity2 may be related to the decrease in leptin levels that were mediated by the loss of body fat in the obese, postmenopausal @entity0 . International Journal of Obesity (2000)24, 27-32

title: Changes in plasma leptin and insulin action with resistive training in postmenopausal XXXX .

answer: @entity0


abstract: STUDY OBJECTIVE: To examine the morbidity, mortality, and hospital course of an elderly @entity0 sample (mean age, 86 years; 95% CI, 84 to 87) having percutaneous @entity4 . DESIGN: Retrospective consecutive case series before and after balloon valvuloplasty. SETTING: Tertiary care referral hospital. @entity0 : Consecutive sample of 26 @entity0 aged 80 years or older with symptomatic @entity1 referred for balloon valvuloplasty from July 1987 to July 1988. MEASUREMENTS AND MAIN RESULTS: Percutaneous @entity4 reduced the transvalvular gradient from 59 (95% CI, 51 to 67) to 31 mm Hg (95% CI, 26 to 35; P less than 0.0001) and increased aortic valve area from 0.45 (95% CI, 0.38 to 0.51) to 0.67 cm2 (95% CI, 0.58 to 0.76; P less than 0.0001). The mean length of hospital stay for the entire study population was 11.2 days (95% CI, 7.3 to 15.2) at a total hospital charge per @entity0 of  29,600 (95% CI, 21,050 to 38,150). For @entity0 having procedural complications (11 complications in 8 @entity0 ), surgical procedures, or @entity3 , the mean hospital stay increased to 16.2 days (95% CI, 6.2 to 26.2; P less than 0.05) and the hospital charge increased to  44,400 (95% CI, 24,280 to 64,520; P less than 0.01). Two @entity0 who presented with @entity3 died, and 1 @entity0 had an aortic valve replacement before discharge. Four @entity0 were recently discharged (less than 1 month) and follow-up was obtained in the remaining 19 @entity0 at 6.1 months (95% CI, 4.1 to 8.1). Five more @entity0 , including the remaining @entity0 who presented with @entity3 , died after discharge for an overall mortality of 32%. Twelve of the remaining fourteen @entity0 had fewer symptoms and improved an average of 1.1 New York Heart Association classes (95% CI, 0.7 to 1.4; P less than 0.0001). CONCLUSIONS: Percutaneous @entity4 in @entity0 80 years and older improves hemodynamics and symptoms of @entity2 during short-term follow-up in most @entity0 , but overall mortality is high in this elderly @entity0 population. Hospital charges and length of stay were much higher in @entity0 with complications or coexisting medical illnesses. Valvuloplasty is a reasonable alternative treatment for @entity0 with @entity1 who require palliative treatment of symptoms and have high surgical risk.

title: Percutaneous XXXX in octogenarians: morbidity and mortality.

answer: @entity4


abstract: BACKGROUND AND OBJECTIVE: Positive selection of peripheral blood stem cells (PBSC) has been investigated in @entity5 ( @entity5 ) with the aims of reducing plasma cell (PC) contamination of the leukaphereses and improving clinical outcome of autografted @entity0 . DESIGN AND METHODS: In our center 39 untreated @entity0 with stage II and III @entity5 , younger than 65 years, started high-dose therapy consisting of 4 VAD cycles, collection of PBSC mobilized by 7 g/m(2) @entity1 + @entity3 , and myeloablative treatment with 12 mg/kg @entity6 plus 120 mg/m(2) melphalan. The leukaphereses from 23/39 @entity0 (59%) were processed for positive selection of @entity9 (+) cells using an avidin- @entity7 immunoaffinity device. RESULTS: A reduction of PC contamination of as much as 2 log was found in the post-selection products by a flow-cytometric technique using the monoclonal antibody CD 138 alternatively coupled with @entity10 and cytoplasmatic k or l light chains in separate samples. Hematologic reconstitution and clinical outcome of the 23 @entity0 reinfused with selected @entity9 (+) cells (SEL group) were compared with those of the 16 @entity0 reinfused with unselected cells (UNSEL group). No significant differences were observed between the 2 groups with regards to the median duration of @entity4 and @entity2 , the hematologic support required, the incidence of febrile episodes and @entity8 . At a median follow-up of 18 months (range 5-34) after ASCT, there were 7/23 (32%) continuous complete remissions (CR) in the SEL group and 4/16 (25%) in the UNSEL group; there were 10/23 (44%) continuous partial remissions (PR) and 5/16 (31%) in the SEL and UNSEL groups, respectively. Two @entity0 in the UNSEL group and one @entity0 in the SEL group died of progressive disease. INTERPRETATION AND CONCLUSIONS: Our data show that positive selection allows rapid engraftment of hematopoiesis and low morbidity. Although no significant difference was detected between the two groups in the frequency of CR and PR 3 and 18 months after ASCT, a longer follow-up is needed to evaluate definitively the effect of @entity9 (+) selection on the clinical outcome after ASCT.

title: High-dose therapy in @entity5 : effect of positive selection of XXXX + peripheral blood stem cells on hematologic engraftment and clinical outcome.

answer: @entity9


abstract: BACKGROUND AND OBJECTIVE: Positive selection of peripheral blood stem cells (PBSC) has been investigated in @entity5 ( @entity5 ) with the aims of reducing plasma cell (PC) contamination of the leukaphereses and improving clinical outcome of autografted @entity0 . DESIGN AND METHODS: In our center 39 untreated @entity0 with stage II and III @entity5 , younger than 65 years, started high-dose therapy consisting of 4 VAD cycles, collection of PBSC mobilized by 7 g/m(2) @entity1 + @entity3 , and myeloablative treatment with 12 mg/kg @entity6 plus 120 mg/m(2) melphalan. The leukaphereses from 23/39 @entity0 (59%) were processed for positive selection of @entity9 (+) cells using an avidin- @entity7 immunoaffinity device. RESULTS: A reduction of PC contamination of as much as 2 log was found in the post-selection products by a flow-cytometric technique using the monoclonal antibody CD 138 alternatively coupled with @entity10 and cytoplasmatic k or l light chains in separate samples. Hematologic reconstitution and clinical outcome of the 23 @entity0 reinfused with selected @entity9 (+) cells (SEL group) were compared with those of the 16 @entity0 reinfused with unselected cells (UNSEL group). No significant differences were observed between the 2 groups with regards to the median duration of @entity4 and @entity2 , the hematologic support required, the incidence of febrile episodes and @entity8 . At a median follow-up of 18 months (range 5-34) after ASCT, there were 7/23 (32%) continuous complete remissions (CR) in the SEL group and 4/16 (25%) in the UNSEL group; there were 10/23 (44%) continuous partial remissions (PR) and 5/16 (31%) in the SEL and UNSEL groups, respectively. Two @entity0 in the UNSEL group and one @entity0 in the SEL group died of progressive disease. INTERPRETATION AND CONCLUSIONS: Our data show that positive selection allows rapid engraftment of hematopoiesis and low morbidity. Although no significant difference was detected between the two groups in the frequency of CR and PR 3 and 18 months after ASCT, a longer follow-up is needed to evaluate definitively the effect of @entity9 (+) selection on the clinical outcome after ASCT.

title: High-dose therapy in XXXX : effect of positive selection of @entity9 + peripheral blood stem cells on hematologic engraftment and clinical outcome.

answer: @entity5


abstract: Sixty-four @entity1 were observed among 1,039 @entity0 operated for @entity3 between 1975 and 1984. (Statement: July 1987). The second @entity2 tended to develop at a distance from the first resection performed for a lesion with good prognostic factors. Their site and histology present no unusual features. 64% appeared in the contralateral lung; 78% had the same histological type as the first @entity2 . Among 28 @entity0 treated by surgery, 26 had a second resection: there were two peri-operative deaths and 4 major complications. Among the 36 @entity0 rejected for surgery, 21 had excessively altered lung function tests. 30 @entity0 were treated with radiotherapy, 7 with chemotherapy first; one had no treatment. The survival rate for the whole group was quite good: 26% at three years; it was significantly better after a second resection: 41% at three years. Overall survival seems comparable with that of the @entity0 operated upon for a single @entity4 .

title: [Analysis of 64 second XXXX of the bronchi].

answer: @entity2


abstract: @entity7 has been found to activate the gluconeogenic pathway in perfused isolated @entity1 liver. Whether a net increase in the production of @entity2 is observed is a function of the relative concentrations of the @entity2 precursor and the @entity3 . The kinetics of @entity7 interaction with the gluconeogenic pathway are influenced by the rate changes induced by decreases in @entity5 concentration as a result of the increased @entity4 redox potential produced by the oxidation of @entity3 . Taking this into account, two distinct effects of @entity7 were identified. The first is an increase in the Vmax even at the lowest (25 microM) concentration of the @entity3 tested. The second is a progressive decrease in [ @entity5 ]0.5 as a function of @entity7 concentration. The latter occurs at low (less than 0.1 mM), presumably physiological, @entity5 concentrations, when its mitochondrial transport is limiting, indicating that this process must have been activated. The former is observable even at high (greater than 0.5 mM), supraphysiological, concentrations of @entity5 , when its mitochondrial transport is not limiting, indicating that a distal step, presumably @entity5 carboxylation, is activated. The action of @entity7 in increasing gluconeogenesis has been found not to be related to a decreased flux through @entity5 dehydrogenase, neither to changes in the @entity4 redox potential nor to its ability to increase energy production. Actually, the @entity0 uptake induced by @entity7 was largely accounted for by the production of @entity6 body and the latter process was found to be independent of variations in energy demand.

title: Control of hepatic gluconeogenesis: role of XXXX oxidation.

answer: @entity3


abstract: There is a strong demand to identify new strategies for disinfection and treatment of @entity0 , animal, and plant pathogens. The presented work shows the potential of clay minerals to contribute to the development of novel disinfection materials. Enhanced antimicrobial effect of a photoactive organic dye, @entity7 (MB), in the colloids of clay mineral was observed. Singlet @entity1 (1O2) formed upon visible light irradiation was detected directly using luminescence measurements atthe near-infrared region and by spin-trapping method. While MB adsorbed on clay colloid particles lost the ability to produce 1O2 due to @entity2 , surprisingly, the antimicrobial activity was significantly enhanced. Under visible light irradiation, MB/clay minerals dispersions prevented the sporulation of A. @entity5 and Penicillium sp. and inhibited the growth of @entity6 by an additional 6-15% when compared with MB solution. In the experiments with @entity3 , the efficiency of MB was increased by the reduction of surviving cells by 27 and 33%. @entity4 proved to be the most susceptible to MB/clay dispersions. Only less than 20% cells survived with respect to the control experiment at the low MB concentration (1.1 x 10(-6) mol dm(-3)). The contradiction between the significant antimicrobial properties of MB in clay colloidal systems and low 1O2 formation can be explained in terms of the photosensitization mechanism. The role of clay particles is most likely to promote the contact between microorganism cells and photoactive MB. Although the dye directly bound to the clay surface exhibits significantly reduced photoactivity, the presence of clay mediates the delivery of dye molecules on the surface or inside cells. The results indicate new perspectives of potential implementations of clay minerals as parts of complex disinfection materials for industrial applications or in understanding similar processes in nature.

title: Clay mineral particles as effficient carriers of XXXX used for antimicrobial treatment.

answer: @entity7


abstract: In Germany, the incidence of @entity6 is approximately 1/100,000 and has not risen during recent years. Transmission occurs by direct contact with respiratory droplets, mostly from asymptomatic carriers and less frequently from @entity0 with @entity1 . The incubation period can vary from 2-10 days but usually is 3-4 days. Incidence is highest in @entity0 and decreases with age. The mortality from @entity6 is approximately 10%. In case @entity7 is clinically suspected antibiotic treatment (in Germany with @entity5 or a cephalosporin) should not be delayed. @entity0 must be isolated for at least 24 hours after the institution of antibiotic therapy. For early detection of local outbreaks, public health authorities should be quickly informed of suspected cases. @entity0 in close contact should be treated with antimicrobial chemoprophylaxis. In addition to @entity2 , @entity3 or @entity4 can be used for chemoprophylaxis. For control of local outbreaks of serogroup C @entity6 , the meningococcal vaccine can be used.

title: [Prevention of XXXX ].

answer: @entity7


abstract: Data from the population-based Metropolitan Atlanta Developmental Disabilities Surveillance Program (MADDSP) were used to describe the underlying causes of @entity1 ( @entity6 ; corrected @entity1 in the better eye of 20/70 or worse) in young @entity0 (n = 228) in metropolitan Atlanta in 1991-93. @entity0 with @entity6 were identified through record review at multiple educational and medical sources. @entity0 were categorised as having isolated @entity6 or @entity2 (i.e. @entity6 plus one or more of four additional @entity2 ) and as having @entity5 ( @entity1 20/70-20/400) or @entity4 ( @entity1 worse than 20/400). Medical conditions abstracted from MADDSP sources were reviewed to determine the probable aetiology of a @entity0 's @entity6 . Aetiologies were assigned to one of three developmental time periods: prenatal, perinatal, or postnatal. Prenatal aetiologies were identified in 43% of the @entity0 ; 38% of the prenatal aetiologies were genetic. Perinatal aetiologies were found in 27% of the @entity0 . Postnatal aetiologies were rare. Prenatal aetiologies were more common in @entity0 with isolated @entity6 ; perinatal and postnatal aetiologies were more common in @entity0 with @entity2 . @entity0 with prenatal aetiologies tended to have less severe @entity3 than did @entity0 with perinatal or postnatal aetiologies. The distribution varied by birthweight, but did not differ significantly by sex or race.

title: Aetiology of childhood XXXX , metropolitan Atlanta, 1991-93.

answer: @entity1


abstract: PURPOSE: To determine the safety and efficacy of an intraocular @entity5 drug delivery system (Surodex) in the treatment of @entity1 following @entity4 surgery. METHODS: Surodex is a biodegradable polymer that releases @entity5 for 7 to 10 days after placement in the anterior segment. Study 1 was a prospective, randomized, double-masked Phase II clinical trial of 90 @entity4 surgical @entity0 that compared treatment with Surodex to treatment with a placebo drug delivery system and to no anti-inflammatory drug treatment at all. Study 2 was a separate prospective, randomized, double-masked study of 60 @entity4 surgical @entity0 that compared treatment with Surodex to topical @entity5 (eye drop) therapy. RESULTS: In the first study, Surodex was superior to placebo in suppressing postsurgical @entity1 throughout the 60-day postoperative period, as judged by masked-evaluator, slit-lamp grading of cell and flare. The differences were statistically significant from postoperative day 3 through postoperative week 3. The majority of Surodex @entity0 did not require topical @entity2 by 2 weeks after surgery (93%) or by 2 months after surgery (88%). In the second study, Kowa laser flare meter readings were lower in Surodex @entity0 throughout the 90-day postoperative period. The results were statistically significant at 4, 8, and 15 days following surgery. There were no significant adverse complications of Surodex in either study. CONCLUSION: Surodex was safe and effective in suppressing postcataract surgery @entity1 and appears to be a promising alternative to topical @entity3 .

title: Two clinical trials of an intraocular XXXX delivery system for @entity4 surgery.

answer: @entity2


abstract: PURPOSE: To determine the safety and efficacy of an intraocular @entity5 drug delivery system (Surodex) in the treatment of @entity1 following @entity4 surgery. METHODS: Surodex is a biodegradable polymer that releases @entity5 for 7 to 10 days after placement in the anterior segment. Study 1 was a prospective, randomized, double-masked Phase II clinical trial of 90 @entity4 surgical @entity0 that compared treatment with Surodex to treatment with a placebo drug delivery system and to no anti-inflammatory drug treatment at all. Study 2 was a separate prospective, randomized, double-masked study of 60 @entity4 surgical @entity0 that compared treatment with Surodex to topical @entity5 (eye drop) therapy. RESULTS: In the first study, Surodex was superior to placebo in suppressing postsurgical @entity1 throughout the 60-day postoperative period, as judged by masked-evaluator, slit-lamp grading of cell and flare. The differences were statistically significant from postoperative day 3 through postoperative week 3. The majority of Surodex @entity0 did not require topical @entity2 by 2 weeks after surgery (93%) or by 2 months after surgery (88%). In the second study, Kowa laser flare meter readings were lower in Surodex @entity0 throughout the 90-day postoperative period. The results were statistically significant at 4, 8, and 15 days following surgery. There were no significant adverse complications of Surodex in either study. CONCLUSION: Surodex was safe and effective in suppressing postcataract surgery @entity1 and appears to be a promising alternative to topical @entity3 .

title: Two clinical trials of an intraocular @entity2 delivery system for XXXX surgery.

answer: @entity4


abstract: Sixty-six cases of @entity5 due to @entity3 from December 1984 to June 1988 were analysed. A discrepancy of 28.8% existed between hysterosalpingography and operative findings, e. g. X-ray revealed blocked tubes, but during operation the tubes were found to be patent. The abnormal and marked tortuosity giving rise to resistance to the passage of oil at the ampullar portion of tubes in the majority of cases may be the explanation. Pathological examination of 48 specimens revealed the chief cause of obstruction was nonspecific infection (50.0%). The next @entity2 (31.3%). The third isthmic @entity4 (6.25%) and the fourth @entity0 (4.2%). Operative procedures were done for the purpose of ovum pick-up and to treat the diseased tubes. Three cases of clinical pregnancy as the result of intra-operative ovum pick-up in a program of IVF/ET occurred after 1987 when our IVF technology gradually improved. This result suggests that operation on the tubes did not jeopardize the process of implantation. Among the 14 cases followed up for more than one year 3 cases became pregnant. Operations to relax and straighten up the tortuous part of the tubes or instillation of fluid into the tubes and transplantation of the healthy tube into the single horn uterus were effective. To do an @entity1 on the chronically inflamed and thickened tubes was not helpful.

title: [ XXXX due to @entity3 and clinicopathologic study of 66 cases].

answer: @entity5


abstract: Sixty-six cases of @entity5 due to @entity3 from December 1984 to June 1988 were analysed. A discrepancy of 28.8% existed between hysterosalpingography and operative findings, e. g. X-ray revealed blocked tubes, but during operation the tubes were found to be patent. The abnormal and marked tortuosity giving rise to resistance to the passage of oil at the ampullar portion of tubes in the majority of cases may be the explanation. Pathological examination of 48 specimens revealed the chief cause of obstruction was nonspecific infection (50.0%). The next @entity2 (31.3%). The third isthmic @entity4 (6.25%) and the fourth @entity0 (4.2%). Operative procedures were done for the purpose of ovum pick-up and to treat the diseased tubes. Three cases of clinical pregnancy as the result of intra-operative ovum pick-up in a program of IVF/ET occurred after 1987 when our IVF technology gradually improved. This result suggests that operation on the tubes did not jeopardize the process of implantation. Among the 14 cases followed up for more than one year 3 cases became pregnant. Operations to relax and straighten up the tortuous part of the tubes or instillation of fluid into the tubes and transplantation of the healthy tube into the single horn uterus were effective. To do an @entity1 on the chronically inflamed and thickened tubes was not helpful.

title: [ @entity5 due to XXXX and clinicopathologic study of 66 cases].

answer: @entity3


abstract: @entity4 are extremely rare and most commonly caused by @entity10 , @entity1 or @entity7 . Less frequently seen causes also include syphilis, cystic media @entity0 or @entity3 or @entity2 . The presence of a subclavian @entity5 can give rise to various symptoms such as a pulsating supraclavicular mass, @entity8 or @entity9 . Generally, surgical intervention is undertaken involving ligation and extirpation of the @entity5 followed by interposition of either a saphenous vein- or synthetic vascular graft. Recent diversifications in potential therapeutic strategies include the clinical application of transluminally positioned stents for the treatment of @entity6 . In the literature review we found more than 260 published cases of surgically treated subclavian @entity5 and additional 17 subclavian @entity5 treated by endoluminal stent application. From 1992-1997 5 subclavian @entity5 were resected in our hospital. In four cases a vein graft of the vena saphena magna and in one case a PTFE graft were used. The sensory ischaemic deficit regressed in the further follow up in four of the five cases. Patency was checked postoperatively by ultrasound sonography, angiography or MR-angiography.

title: [Surgical and interventional therapeutic possibilities in XXXX ].

answer: @entity4