abstract: PURPOSE: A biomarker for dietary @entity2 intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of @entity1 from these sources for the prevention of @entity0 . Urinary @entity3 (HA)-a major metabolite of @entity1 -is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV. METHODS: Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9-16  years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (n  =  192) and confirmation (n  =  95) of results. RESULTS: Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (r unadjusted  =  0.47, P  <  0.0001). Yet, 79  % of the subjects were classified into same/adjacent quartiles, and only 5  % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (r unadjusted  =  0.64; 88  % in same/adjacent vs. 4  % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples. CONCLUSIONS: BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.

title: Relative validation of 24-h urinary XXXX excretion as a biomarker for dietary @entity2 intake from fruit and vegetables in healthy adolescents.

answer: @entity3


abstract: BACKGROUND: @entity6 ( @entity6 ) are a heterogeneous group of rare @entity2 of sex determination or differentiation. Evidence-based guidelines concerning gender assignment and surgical and hormonal treatment are limited for many @entity6 entities, and health care is highly fragmented across various sub-specialties and settings. A lack of informed consent, secrecy about the condition, shame, and @entity1 may affect satisfaction with care. OBJECTIVES: The main goal of this study was to describe satisfaction with care in individuals with @entity6 and to identify factors associated with low satisfaction with care. METHODS/MAIN MEASURES: Using both biological (chromosomes) and social categories (sex of rearing), we classified @entity0 according to the nomenclature of the European Society for Pediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society (ESPE/LWPES) consensus statement. We used standardized measures to assess satisfaction with care (CSQ-8), health-related quality of life (SF-36), @entity5 (BSI), and gender identity (FGI), in addition to self-constructed questionnaires probing experiences with health care and access to self-help groups. @entity0 : A total of 110 adults were recruited between January 2005 and December 2007 in four study centers in Germany, Austria, and German-speaking Switzerland. RESULTS: Reports of half the @entity0 scored below the cut-off indicating low quality of care. @entity0 with XX @entity6 conditions and virilization (i.e., @entity4 ) reported the highest scores for satisfaction with care, and @entity0 with XY @entity6 conditions and complete lack of @entity3 effects reported the lowest scores. Satisfaction with care was positively associated with indicators of psychological well-being. CONCLUSIONS: Satisfaction with care is lowest among @entity0 with the rarest conditions, highlighting the lack of evidence-based recommendations and the lack of coordination of care. Associations of satisfaction and well-being indicate the need to ensure access to mental health services.

title: Utilization of health care services and satisfaction with care in adults affected by XXXX ( @entity6 ).

answer: @entity6


abstract: BACKGROUND: @entity6 ( @entity6 ) are a heterogeneous group of rare @entity2 of sex determination or differentiation. Evidence-based guidelines concerning gender assignment and surgical and hormonal treatment are limited for many @entity6 entities, and health care is highly fragmented across various sub-specialties and settings. A lack of informed consent, secrecy about the condition, shame, and @entity1 may affect satisfaction with care. OBJECTIVES: The main goal of this study was to describe satisfaction with care in individuals with @entity6 and to identify factors associated with low satisfaction with care. METHODS/MAIN MEASURES: Using both biological (chromosomes) and social categories (sex of rearing), we classified @entity0 according to the nomenclature of the European Society for Pediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society (ESPE/LWPES) consensus statement. We used standardized measures to assess satisfaction with care (CSQ-8), health-related quality of life (SF-36), @entity5 (BSI), and gender identity (FGI), in addition to self-constructed questionnaires probing experiences with health care and access to self-help groups. @entity0 : A total of 110 adults were recruited between January 2005 and December 2007 in four study centers in Germany, Austria, and German-speaking Switzerland. RESULTS: Reports of half the @entity0 scored below the cut-off indicating low quality of care. @entity0 with XX @entity6 conditions and virilization (i.e., @entity4 ) reported the highest scores for satisfaction with care, and @entity0 with XY @entity6 conditions and complete lack of @entity3 effects reported the lowest scores. Satisfaction with care was positively associated with indicators of psychological well-being. CONCLUSIONS: Satisfaction with care is lowest among @entity0 with the rarest conditions, highlighting the lack of evidence-based recommendations and the lack of coordination of care. Associations of satisfaction and well-being indicate the need to ensure access to mental health services.

title: Utilization of health care services and satisfaction with care in adults affected by @entity6 ( XXXX ).

answer: @entity6


abstract: OBJECTIVE: To determine the frequency of @entity1 ( @entity1 ) plateaus and reversals in the Pooled Resource Open-Access @entity1 Clinical Trials (PRO-ACT) database. METHODS: We analyzed Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) and ALSFRS-revised (ALSFRS-R) data from PRO-ACT @entity0 . The frequencies of @entity0 experiencing plateaus (periods where scores did not change) were calculated over 6-, 12-, and 18-month epochs. The percentage of @entity0 ever experiencing reversals (periods where scores improved) of different lengths were also calculated and plotted. RESULTS: Over 6 months, 25% of 3,132 @entity0 did not decline. Over 12 months, 16% of 2,105 @entity0 did not decline. Over 18 months, 7% of 1,218 @entity0 did not decline. Small @entity1 reversals were also common, especially over shorter follow-up intervals; 14% of 1,343 @entity0 had a 180-day interval where their ALSFRS-R slope was greater than zero. Fewer than 1% of @entity0 ever experienced improvements of 4 or more ALSFRS-R points lasting at least 12 months. CONCLUSION: @entity1 plateaus and small reversals are common, especially over brief intervals. In light of these data, stable disease, especially for a short period of time, should not be interpreted as an @entity1 treatment effect. Large sustained @entity1 reversals, on the other hand, are rare, potentially important, and warrant further study.

title: How common are XXXX plateaus and reversals?

answer: @entity1


abstract: AIMS: To describe the characteristics of @entity3 ( @entity3 ) in @entity0 treated in a paediatric emergency department and to detect clinical differences, depending on whether the condition was ischaemic or @entity7 . @entity0 AND METHODS: An analytical, observation-based, retrospective study was conducted in the paediatric emergency department of a tertiary care hospital. The sample included @entity0 aged between 1 month and 18 years who were treated in the service over a period of 10 years (January 2001 to December 2011) with a final diagnosis of @entity3 . @entity7 due to @entity4 or secondary to @entity1 , @entity8 of the venous sinuses and @entity0 who were not treated in the service were all excluded. RESULTS: The final sample consisted of 61 @entity0 , 39 (63.9%) of whom were males, with a mean age of 4.6 years (range: 1.3 months-17.5 years). Of them, 26 (42.6%) presented @entity3 and 35 (57.4%) had @entity7 . @entity2 (n = 20; 57.1%; p = 0.008) and @entity5 (n = 25; 71.4%; p = 0.001) are more frequent in @entity7 , and @entity10 (n = 17; 65.4%; p < 0.001) and @entity12 (n = 7; 26.9%; p = 0.001) in @entity3 . The main causes of @entity7 are @entity11 (n = 17; 38.6%) and the ischaemic ones are triggered by arteriopathies (n = 6; 42.3%). On discharge from hospital, 27 (44.3%) presented @entity9 and 6 (9.8%) died. CONCLUSIONS: @entity3 is a rare entity, although it presents a high morbidity and mortality rate. @entity7 is seen to predominate slightly and it is observed how @entity7 presents more often with signs of @entity6 , while the ischaemic form tends to have more neurological focus.

title: [Stroke in XXXX . Experience in an emergency service].

answer: @entity0


abstract: Only a minor proportion of @entity0 with acute @entity2 receive treatment with intravenous thrombolysis. The purpose of this study was to explore reasons for not giving thrombolysis and to determine if there was a correlation between prehospital and in-hospital delay in a Norwegian @entity2 . @entity0 with acute @entity2 were included during a 1-year period. Time intervals for prehospital and in-hospital delay, reasons for not treating with thrombolytic therapy in @entity0 admitted within the time window and reasons for late arrival were recorded. In all, 290 @entity0 were included, and 7.6  % were treated with intravenous thrombolysis. The most frequent reasons for not treating eligible @entity0 were: minor symptoms (22.8  %), clinical improvement (17.5  %) and uncertainty about the diagnosis (12.3  %). @entity0 ' reasons for delayed admission were: not attributing their symptoms to @entity1 (25.4  %), a wait-and-see attitude (25.4  %), and choosing to wait for the GP's office to open (14.3  %). Prehospital delay was strongly correlated to in-hospital delay (p  <  0.001). In conclusion, a large percentage of @entity0 with @entity3 are not treated with thrombolysis because of mild or rapidly improving symptoms, and because @entity0 arrive too late to the hospital. Absolute and relative contraindications account for a minor proportion of reasons for excluding @entity0 .

title: Reasons for low thrombolysis rate in a Norwegian XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity4 ( @entity4 ) cause @entity1 and decreased physical ability, with no known well-established treatment. The aim of this study was to illuminate the experience of living with a @entity4 . The results show that fear and concerns are a major part of daily life. The @entity0 's initial contact with health-care providers should focus on making them feel acknowledged by offering @entity0 -centered and tailored support. INTRODUCTION: In the past decade, @entity3 have become an increasingly common and costly public health problem worldwide. @entity4 ( @entity4 ) is the second most common @entity3 , and @entity0 with @entity4 describe an abrupt descent into disability, with a subsequent desire to regain independence in everyday life; however, little is known of their situation. The aim of this study was to illuminate the lived experience of @entity0 with an @entity4 . METHODS: Ten @entity0 were interviewed during 2012-2013, starting with an open-ended question: could you tell me what it is like to live with a vertebral compression @entity2 ? The verbatim transcribed interviews were analyzed using a phenomenological hermeneutical approach. RESULTS: The narrative provided descriptions of living in turmoil and chaos, unable to find stability in their life with little improvement regarding @entity1 and physical function. Shifts from periods of @entity1 to periods of fear of @entity1 created a loss of confidence and an increased sense of confinement. The structural analysis revealed fear and concerns as the most prominent experience building on five themes: struggling to understand a deceiving body, @entity1 fueling fear, fearing a trajectory into isolation, concerns of dependency, and fearing an uncertain future. CONCLUSIONS: Until researchers find a successful prevention or medical/surgical treatment for @entity3 , health-care providers and society abandon these @entity0 to remain in a @entity1 and never ending story.

title: A XXXX , never ending story: older @entity0 's experiences of living with an osteoporotic vertebral compression @entity2 .

answer: @entity1


abstract: UNASSIGNED: @entity4 ( @entity4 ) cause @entity1 and decreased physical ability, with no known well-established treatment. The aim of this study was to illuminate the experience of living with a @entity4 . The results show that fear and concerns are a major part of daily life. The @entity0 's initial contact with health-care providers should focus on making them feel acknowledged by offering @entity0 -centered and tailored support. INTRODUCTION: In the past decade, @entity3 have become an increasingly common and costly public health problem worldwide. @entity4 ( @entity4 ) is the second most common @entity3 , and @entity0 with @entity4 describe an abrupt descent into disability, with a subsequent desire to regain independence in everyday life; however, little is known of their situation. The aim of this study was to illuminate the lived experience of @entity0 with an @entity4 . METHODS: Ten @entity0 were interviewed during 2012-2013, starting with an open-ended question: could you tell me what it is like to live with a vertebral compression @entity2 ? The verbatim transcribed interviews were analyzed using a phenomenological hermeneutical approach. RESULTS: The narrative provided descriptions of living in turmoil and chaos, unable to find stability in their life with little improvement regarding @entity1 and physical function. Shifts from periods of @entity1 to periods of fear of @entity1 created a loss of confidence and an increased sense of confinement. The structural analysis revealed fear and concerns as the most prominent experience building on five themes: struggling to understand a deceiving body, @entity1 fueling fear, fearing a trajectory into isolation, concerns of dependency, and fearing an uncertain future. CONCLUSIONS: Until researchers find a successful prevention or medical/surgical treatment for @entity3 , health-care providers and society abandon these @entity0 to remain in a @entity1 and never ending story.

title: A @entity1 , never ending story: older @entity0 's experiences of living with an osteoporotic vertebral compression XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity4 ( @entity4 ) cause @entity1 and decreased physical ability, with no known well-established treatment. The aim of this study was to illuminate the experience of living with a @entity4 . The results show that fear and concerns are a major part of daily life. The @entity0 's initial contact with health-care providers should focus on making them feel acknowledged by offering @entity0 -centered and tailored support. INTRODUCTION: In the past decade, @entity3 have become an increasingly common and costly public health problem worldwide. @entity4 ( @entity4 ) is the second most common @entity3 , and @entity0 with @entity4 describe an abrupt descent into disability, with a subsequent desire to regain independence in everyday life; however, little is known of their situation. The aim of this study was to illuminate the lived experience of @entity0 with an @entity4 . METHODS: Ten @entity0 were interviewed during 2012-2013, starting with an open-ended question: could you tell me what it is like to live with a vertebral compression @entity2 ? The verbatim transcribed interviews were analyzed using a phenomenological hermeneutical approach. RESULTS: The narrative provided descriptions of living in turmoil and chaos, unable to find stability in their life with little improvement regarding @entity1 and physical function. Shifts from periods of @entity1 to periods of fear of @entity1 created a loss of confidence and an increased sense of confinement. The structural analysis revealed fear and concerns as the most prominent experience building on five themes: struggling to understand a deceiving body, @entity1 fueling fear, fearing a trajectory into isolation, concerns of dependency, and fearing an uncertain future. CONCLUSIONS: Until researchers find a successful prevention or medical/surgical treatment for @entity3 , health-care providers and society abandon these @entity0 to remain in a @entity1 and never ending story.

title: A @entity1 , never ending story: older XXXX 's experiences of living with an osteoporotic vertebral compression @entity2 .

answer: @entity0


abstract: BACKGROUND: @entity2 remains a major public health problem whose management is hampered by poor persistence with pharmacological therapy. The aim of this study was to evaluate the association between discontinuing @entity3 ( @entity3 ) and the risk of @entity1 in the elderly. METHODS: A population-based prospective cohort study of all of the >=  60-year-old residents in Bambu   city (Brazil) enrolled 1606 subjects (92.2%), of whom 1494 (93.0%) were included in this study. The use of @entity3 was ascertained annually in a real-clinical context, and time-varying @entity4 exposure was categorised as non-use, current use or stopped. The predicted @entity1 rates were estimated using interval Poisson models for ungrouped @entity0 -time data, taking into account current levels of systolic blood pressure (BP). RESULTS: The overall adjusted @entity1 risk ratio of @entity4 stoppers vs current users was 3.12 (95% CI: 2.35-4.15). There was a significant interaction with BP levels: the association between discontinuing @entity3 and the risk of @entity1 was stronger at higher systolic BP levels. The estimates of the risk of @entity1 over the follow-up period were similar in @entity4 users and non-users, for whom @entity3 were never prescribed. CONCLUSION: Discontinuing @entity3 increases the risk of @entity1 in the elderly. Misconceptions about symptoms or drug-related adverse effects could underlie a subject's decision to discontinue @entity3 . Greater attention should be paid to the choice of @entity3 and informative action.

title: Discontinuation of anti- XXXX drugs increases 11-year @entity1 risk in community-dwelling elderly (the Bambu   Cohort Study of Ageing).

answer: @entity2


abstract: BACKGROUND: @entity2 remains a major public health problem whose management is hampered by poor persistence with pharmacological therapy. The aim of this study was to evaluate the association between discontinuing @entity3 ( @entity3 ) and the risk of @entity1 in the elderly. METHODS: A population-based prospective cohort study of all of the >=  60-year-old residents in Bambu   city (Brazil) enrolled 1606 subjects (92.2%), of whom 1494 (93.0%) were included in this study. The use of @entity3 was ascertained annually in a real-clinical context, and time-varying @entity4 exposure was categorised as non-use, current use or stopped. The predicted @entity1 rates were estimated using interval Poisson models for ungrouped @entity0 -time data, taking into account current levels of systolic blood pressure (BP). RESULTS: The overall adjusted @entity1 risk ratio of @entity4 stoppers vs current users was 3.12 (95% CI: 2.35-4.15). There was a significant interaction with BP levels: the association between discontinuing @entity3 and the risk of @entity1 was stronger at higher systolic BP levels. The estimates of the risk of @entity1 over the follow-up period were similar in @entity4 users and non-users, for whom @entity3 were never prescribed. CONCLUSION: Discontinuing @entity3 increases the risk of @entity1 in the elderly. Misconceptions about symptoms or drug-related adverse effects could underlie a subject's decision to discontinue @entity3 . Greater attention should be paid to the choice of @entity3 and informative action.

title: Discontinuation of anti- @entity2 drugs increases 11-year XXXX risk in community-dwelling elderly (the Bambu   Cohort Study of Ageing).

answer: @entity1


abstract: Hepatic @entity9 , consisting of resident KCs and infiltrating monocytes/IMs, are thought to play an important role in the pathogenesis of @entity5 . Previous work has focused on KCs or studied hepatic @entity9 as one cell population. The aim of the current study is to distinguish IMs from KCs and to compare their phenotypes and functions. We show here that a 4-week @entity3 feeding of C57BL/6J @entity0 causes recruitment of IMs into the liver. KCs and IMs can be distinguished based on their differential expression of @entity7 and @entity4 . IMs can be divided further into two subsets based on their differential expression of @entity8 . KCs and two subsets of IMs were separately purified by @entity6 . The phagocytosis abilities and the expression profiles of genes related to various functions were compared among different populations of hepatic @entity9 . @entity8 (low) IMs exhibit an anti-inflammatory and tissue-protective phenotype; in contrast, @entity8 (hi) IMs exhibit a proinflammatory, tissue-damaging phenotype. The ratio of @entity8 (hi)/ @entity8 (low) increases when @entity0 chronically fed @entity3 were binged, which significantly enhanced @entity2 . Moreover, upon phagocytosis of apoptotic hepatocytes, @entity8 (hi) IMs switch to @entity8 (low) IMs. Taken together, chronic @entity3 feeding induces the recruitment of two subsets of hepatic IMs, which play different or even opposite roles in regulating liver @entity1 and repair. These findings may not only increase our understanding of the complex functions of @entity9 in the pathogenesis of @entity5 but also help us to identify novel therapeutic targets for the treatment of this disease.

title: Chronic alcohol ingestion modulates hepatic macrophage populations and functions in XXXX .

answer: @entity0


abstract: @entity4 coatings, used in many surgical devices, have demonstrated good antimicrobial activity and low @entity2 . Oncological musculoskeletal surgery have a high risk of @entity3 , so in the last decades, @entity4 -coated mega-prostheses have been introduced and are becoming increasingly widespread. In this study, a retrospective analysis of 158 cases of @entity5 , primary or metastatic, treated between 2005- 2015 with wide margins resection and @entity1 implants reconstruction, was performed. The average age was 59 years (range 11-78 years), the same surgeon with antibiotic prophylaxis according to a standard protocol treated all @entity0 . @entity4 -coated prostheses were implanted in 58.5% of @entity0 and uncoated @entity1 prostheses in the remaining 41.5%. @entity0 were re-evaluated annually and complications were recorded, focusing analysis on infective complications. The average follow-up was 39.7 months: 23.4% of @entity0 died at a median time of 35.3 months after surgery; 18.4% developed complications that required new surgery, of which 12.6% of these were due to @entity3 . @entity0 treated with @entity4 -coated implants developed @entity3 in 2.2% of cases against the 10.7% of the @entity0 treated with standard @entity1 prosthesis. This difference between the two groups was statistically significant. The percentage of late infections occurring from 6 months after surgery was similar in both groups. @entity4 blood level taken in a sample of @entity0 at different times after surgery, always showed values well below the threshold of @entity2 and no @entity0 showed any sign of local or general @entity2 secondary to @entity4 . Our study demonstrates that @entity1 @entity4 -coated implants have a rate of @entity3 significantly lower than traditional implants, while there were no differences in the rate of late infections as described also in the literature. We recommend the use of @entity4  coated prosthesis as primary implants for limb salvage surgery in primary or metastatic @entity5 , considering the absence of @entity2 and the lower rate of @entity3 .

title: XXXX COATED PROSTHESIS IN ONCOLOGICAL LIMB SALVAGE SURGERY REDUCE THE INFECTION RATE.

answer: @entity4


abstract: Object It is common practice to use a new contralateral bur hole for ventriculoperitoneal shunt (VPS) placement in @entity2 ( @entity2 ) @entity0 with an existing ventriculostomy. At Thomas Jefferson University and Jefferson Hospital for Neuroscience, the authors have primarily used the ventriculostomy site for the VPS. The purpose of this study was to compare the safety of the 2 techniques in @entity0 with @entity2 . Methods The rates of VPS-related @entity3 , @entity1 , and proximal revision were compared between the 2 techniques in 523 @entity0 undergoing VPS placement (same site in 464 and contralateral site in 59 @entity0 ). Results The rate of new VPS-related @entity3 was significantly higher in the contralateral-site group (1.7%) than in the same-site group (0%; p = 0.006). The rate of @entity1 did not differ between the 2 groups (6.4% for same site vs 5.1% for contralateral site; p = 0.7). In multivariate analysis, higher Hunt and Hess grades (p = 0.05) and open versus endovascular treatment (p = 0.04) predicted @entity1 , but the VPS technique was not a predictive factor (p = 0.9). The rate of proximal shunt revision was 6% in the same-site group versus 8.5% in the contralateralsite group (p = 0.4). In multivariate analysis, open surgery was the only factor predicting proximal VPS revision (p = 0.05). Conclusions The results of this study suggest that the use of the ventriculostomy site for VPS placement may be feasible and safe and may not add morbidity ( @entity1 or need for revision) compared with the use of a fresh contralateral site. This rapid and simple technique also was associated with a lower risk of shunt-related @entity3 . While both techniques appear to be feasible and safe, a definitive answer to the question of which technique is superior awaits a higher level of medical evidence.

title: Comparison of techniques for ventriculoperitoneal shunting in 523 @entity0 with XXXX .

answer: @entity2


abstract: Object It is common practice to use a new contralateral bur hole for ventriculoperitoneal shunt (VPS) placement in @entity2 ( @entity2 ) @entity0 with an existing ventriculostomy. At Thomas Jefferson University and Jefferson Hospital for Neuroscience, the authors have primarily used the ventriculostomy site for the VPS. The purpose of this study was to compare the safety of the 2 techniques in @entity0 with @entity2 . Methods The rates of VPS-related @entity3 , @entity1 , and proximal revision were compared between the 2 techniques in 523 @entity0 undergoing VPS placement (same site in 464 and contralateral site in 59 @entity0 ). Results The rate of new VPS-related @entity3 was significantly higher in the contralateral-site group (1.7%) than in the same-site group (0%; p = 0.006). The rate of @entity1 did not differ between the 2 groups (6.4% for same site vs 5.1% for contralateral site; p = 0.7). In multivariate analysis, higher Hunt and Hess grades (p = 0.05) and open versus endovascular treatment (p = 0.04) predicted @entity1 , but the VPS technique was not a predictive factor (p = 0.9). The rate of proximal shunt revision was 6% in the same-site group versus 8.5% in the contralateralsite group (p = 0.4). In multivariate analysis, open surgery was the only factor predicting proximal VPS revision (p = 0.05). Conclusions The results of this study suggest that the use of the ventriculostomy site for VPS placement may be feasible and safe and may not add morbidity ( @entity1 or need for revision) compared with the use of a fresh contralateral site. This rapid and simple technique also was associated with a lower risk of shunt-related @entity3 . While both techniques appear to be feasible and safe, a definitive answer to the question of which technique is superior awaits a higher level of medical evidence.

title: Comparison of techniques for ventriculoperitoneal shunting in 523 XXXX with @entity2 .

answer: @entity0


abstract: INTRODUCTION: Spinal cord and peripheral nerves are classically known to be damaged in @entity5 , but the extent of cerebral involvement in the disease and its progression over time are not yet characterized. The aim of this study was to evaluate @entity2 in @entity5 METHODS: We enrolled 31 @entity0 and 40 controls, which were evaluated at baseline and after 1 and 2 years. To assess gray matter, we employed voxel-based morphometry and cortical thickness measurements. White matter was evaluated using diffusion tensor imaging. Statistical analyses were both cross-sectional and longitudinal (corrected for multiple comparisons). RESULTS: Group comparison between @entity0 and controls revealed widespread macrostructural differences at baseline: gray matter atrophy in the dentate nuclei, brainstem, and precentral gyri; and white matter atrophy in the cerebellum and superior cerebellar peduncles, brainstem, and periventricular areas. We did not identify any longitudinal volumetric change over time. There were extensive microstructural alterations, including superior cerebellar peduncles, corpus callosum, and pyramidal tracts. Longitudinal analyses identified progressive @entity4 at the corpus callosum, pyramidal tracts, and superior cerebellar peduncles after 1 year of follow-up. CONCLUSION: @entity0 with @entity5 present more widespread gray and @entity1 than previously reported, including not only infratentorial areas, but also supratentorial structures. Furthermore, @entity0 with @entity5 have progressive @entity4 amenable to detection in a short-term follow-up.    2015 International Parkinson and @entity3 Society.

title: Longitudinal magnetic resonance imaging study shows progressive pyramidal and XXXX in @entity5 .

answer: @entity2


abstract: INTRODUCTION: Spinal cord and peripheral nerves are classically known to be damaged in @entity5 , but the extent of cerebral involvement in the disease and its progression over time are not yet characterized. The aim of this study was to evaluate @entity2 in @entity5 METHODS: We enrolled 31 @entity0 and 40 controls, which were evaluated at baseline and after 1 and 2 years. To assess gray matter, we employed voxel-based morphometry and cortical thickness measurements. White matter was evaluated using diffusion tensor imaging. Statistical analyses were both cross-sectional and longitudinal (corrected for multiple comparisons). RESULTS: Group comparison between @entity0 and controls revealed widespread macrostructural differences at baseline: gray matter atrophy in the dentate nuclei, brainstem, and precentral gyri; and white matter atrophy in the cerebellum and superior cerebellar peduncles, brainstem, and periventricular areas. We did not identify any longitudinal volumetric change over time. There were extensive microstructural alterations, including superior cerebellar peduncles, corpus callosum, and pyramidal tracts. Longitudinal analyses identified progressive @entity4 at the corpus callosum, pyramidal tracts, and superior cerebellar peduncles after 1 year of follow-up. CONCLUSION: @entity0 with @entity5 present more widespread gray and @entity1 than previously reported, including not only infratentorial areas, but also supratentorial structures. Furthermore, @entity0 with @entity5 have progressive @entity4 amenable to detection in a short-term follow-up.    2015 International Parkinson and @entity3 Society.

title: Longitudinal magnetic resonance imaging study shows progressive pyramidal and @entity2 in XXXX .

answer: @entity5


abstract: Objectives. To assess the relationship between the complement activation route and clinical manifestations in @entity2 ( @entity2 ). Methods. @entity0 with @entity2 in whom complement activation occurred were divided into two groups: those in whom the complement system was mainly activated through the classical pathway (low serum @entity6 levels; CP group); and those in whom the complement system was solely activated through the alternative pathway (low serum C3 with normal C4 levels; AP group). Clinical manifestations were compared between the groups. Results. The CP group had higher frequencies of @entity1 , @entity5 , and @entity3 , and a higher prevalence of anti-DNA antibodies compared to the AP group ( @entity1 : 50.0% vs. 13.0%, p = 0.0014; @entity5 : 37.5% vs. 13.0%, p = 0.0257; @entity3 : 63.6% vs. 21.7%, p = 0.0003; anti-DNA antibodies: 73.9% vs. 30.4%, p = 0.0001). In contrast, the AP group had a higher frequency of anti-phospholipid (anti-PL) antibodies and a higher prevalence of @entity4 ( @entity4 ) (anti-PL antibodies: 70.6% vs. 37.3%, p = 0.0136; @entity4 : 39.1% vs. 5.7%, p < 0.0001). Conclusions. Our results suggest that a different complement system mechanism may act in the pathogenesis of @entity4 in @entity0 with @entity2 .

title: Relationship of complement activation route with clinical manifestations in Japanese @entity0 with XXXX : A retrospective observational study.

answer: @entity2


abstract: Objectives. To assess the relationship between the complement activation route and clinical manifestations in @entity2 ( @entity2 ). Methods. @entity0 with @entity2 in whom complement activation occurred were divided into two groups: those in whom the complement system was mainly activated through the classical pathway (low serum @entity6 levels; CP group); and those in whom the complement system was solely activated through the alternative pathway (low serum C3 with normal C4 levels; AP group). Clinical manifestations were compared between the groups. Results. The CP group had higher frequencies of @entity1 , @entity5 , and @entity3 , and a higher prevalence of anti-DNA antibodies compared to the AP group ( @entity1 : 50.0% vs. 13.0%, p = 0.0014; @entity5 : 37.5% vs. 13.0%, p = 0.0257; @entity3 : 63.6% vs. 21.7%, p = 0.0003; anti-DNA antibodies: 73.9% vs. 30.4%, p = 0.0001). In contrast, the AP group had a higher frequency of anti-phospholipid (anti-PL) antibodies and a higher prevalence of @entity4 ( @entity4 ) (anti-PL antibodies: 70.6% vs. 37.3%, p = 0.0136; @entity4 : 39.1% vs. 5.7%, p < 0.0001). Conclusions. Our results suggest that a different complement system mechanism may act in the pathogenesis of @entity4 in @entity0 with @entity2 .

title: Relationship of complement activation route with clinical manifestations in Japanese XXXX with @entity2 : A retrospective observational study.

answer: @entity0


abstract: The aim of this study was to investigate the expression of @entity5 ( @entity5 ) in bone marrow stromal stem cells (BMSCs) and the in vivo and in vitro osteogenic activity of BMSCs transfected with the adenovirus plasmid, Ad-GFP- @entity4 . The Ad-GFP- @entity4 plasmid was packaged and transfected into @entity1 BMSCs to determine the transfection rate. The alkaline phosphatase (ALP) activities of Ad-GFP- @entity4 -transfected BMSCs (experimental group) and untransfected BMSCs (control group) were detected. In situ hybridization of type I collagen and Western blot were used to determine the @entity5 gene and protein expressions. The transfected and untransfected BMSCs were respectively inoculated into @entity0 to observe in vivo osteogenesis. The decalcified @entity3 cancellous bone scaffold was respectively combined with transfected and untransfected BMSCs and implanted into @entity2 in @entity1 to repair the bone. The adenovirus titer was 1.2x10(10) pfu/mL. Green fluorescent protein expression appeared 48 h after transfection with the adenovirus plasmid, and the transfection rate was 71.1%. The ALP activity was higher in the experimental group than the control group at each time point after transfection. The gene and protein expressions of @entity5 were higher in the experimental group than the control group. The positive rates of in vivo osteogenesis in the experimental and control groups were 90% and 40%, respectively. The bone defect repair effects differed markedly between the two groups. The @entity5 gene can be highly expressed in BMSCs to successfully induce osteogenic differentiation. BMSCs can be used as seed cells for bone tissue engineering.

title: In vivo osteogenic activity of bone marrow stromal stem cells transfected with Ad-GFP- XXXX .

answer: @entity4


abstract: Congenital @entity4 is a rare @entity2 . As a congenital laryngeal mucocele, its clinical manifestations include repeated @entity3 and even suffocation accompanied by @entity5 after birth. During food intake, bucking and vomiting is a key feature. Delay in diagnosis and treatment of the disease affects growth and the development of neonatorum leading to suffocation and @entity1 . This study was designed to investigate the safety of anesthesia in @entity0 with congenital @entity4 during operation to reduce the occurrence of its complications. The treatment of operations on 12 @entity0 with congenital @entity4 were retrospectively analyzed. Twelve cases of @entity0 with @entity4 received emergency enucleation. Owing to adequate preanesthetic preparation, cystectomies were successfully performed with microwave cauterization under suspension laryngoscopy. None of the 12 @entity0 showed apparent suffocation during anesthesia, the surgical results were good, and after 6 months to 1 year of follow-up, the disease had not recurred. Because of the acute onset of the disease and its severe symptoms and complications, attention should be paid to improve preoperative preparation. Careful selection of proper anesthesia is the key to achieving a successful operation.

title: Anesthesia treatment in cases of XXXX epiglottis cyst emergency extirpation operations.

answer: @entity0


abstract: OBJECTIVE: We aimed to elucidate whether @entity4 consumption is associated with a higher risk of @entity5 ( @entity5 ). RESEARCH DESIGN AND METHODS: We analyzed data in three cohorts consisting of U.S. male and female health professionals without @entity2 , @entity3 , and @entity1 at baseline: 70,773 @entity0 from the Nurses' Health Study (1984-2010), 87,739 @entity0 from Nurses' Health Study II (1991-2011), and 40,669 @entity0 from the Health Professionals Follow-up Study (1986-2010). @entity4 consumption was assessed quadrennially using validated food frequency questionnaires (FFQs), and we calculated 4-year change in @entity4 consumption from consecutive FFQs. Self-reported @entity5 diagnosis was confirmed using a validated supplementary questionnaire. RESULTS: During 3,988,007 @entity0 -years of follow-up, 15,362 new cases of @entity5 were identified. Higher consumption of total @entity4 (including baked, boiled, or mashed @entity4 and french fries) was significantly associated with an elevated risk for @entity5 : the pooled hazard ratio (HR) of @entity5 compared with <1 serving/week was 1.07 (95% CI 0.97-1.18) for 2-4 servings/week and 1.33 (95% CI 1.17-1.52) for >= 7 servings/week after adjustment for demographic, lifestyle, and dietary factors. In addition, the pooled HRs of @entity5 for every 3 servings/week were 1.04 (95% CI 1.01-1.08) for baked, boiled, or mashed @entity4 , and 1.19 (95% CI 1.13-1.25) for french fries. We further estimated that the HR of @entity5 was 0.88 (95% CI 0.84-0.91) for replacing 3 servings/week of total @entity4 with the same amount of whole grains. Last, in comparison with stable @entity4 consumption, every 3-servings/week increment of @entity4 consumption in 4 years was associated with a 4% (95% CI 0-8%) higher @entity5 risk. CONCLUSIONS: Greater consumption of @entity4 , especially french fries, was associated with a higher @entity5 risk, independent of BMI and other risk factors. Replacement of @entity4 with whole grains was associated with a lower @entity5 risk.

title: @entity4 Consumption and Risk of Type 2 XXXX : Results from Three Prospective Cohort Studies.

answer: @entity2


abstract: OBJECTIVE: We aimed to elucidate whether @entity4 consumption is associated with a higher risk of @entity5 ( @entity5 ). RESEARCH DESIGN AND METHODS: We analyzed data in three cohorts consisting of U.S. male and female health professionals without @entity2 , @entity3 , and @entity1 at baseline: 70,773 @entity0 from the Nurses' Health Study (1984-2010), 87,739 @entity0 from Nurses' Health Study II (1991-2011), and 40,669 @entity0 from the Health Professionals Follow-up Study (1986-2010). @entity4 consumption was assessed quadrennially using validated food frequency questionnaires (FFQs), and we calculated 4-year change in @entity4 consumption from consecutive FFQs. Self-reported @entity5 diagnosis was confirmed using a validated supplementary questionnaire. RESULTS: During 3,988,007 @entity0 -years of follow-up, 15,362 new cases of @entity5 were identified. Higher consumption of total @entity4 (including baked, boiled, or mashed @entity4 and french fries) was significantly associated with an elevated risk for @entity5 : the pooled hazard ratio (HR) of @entity5 compared with <1 serving/week was 1.07 (95% CI 0.97-1.18) for 2-4 servings/week and 1.33 (95% CI 1.17-1.52) for >= 7 servings/week after adjustment for demographic, lifestyle, and dietary factors. In addition, the pooled HRs of @entity5 for every 3 servings/week were 1.04 (95% CI 1.01-1.08) for baked, boiled, or mashed @entity4 , and 1.19 (95% CI 1.13-1.25) for french fries. We further estimated that the HR of @entity5 was 0.88 (95% CI 0.84-0.91) for replacing 3 servings/week of total @entity4 with the same amount of whole grains. Last, in comparison with stable @entity4 consumption, every 3-servings/week increment of @entity4 consumption in 4 years was associated with a 4% (95% CI 0-8%) higher @entity5 risk. CONCLUSIONS: Greater consumption of @entity4 , especially french fries, was associated with a higher @entity5 risk, independent of BMI and other risk factors. Replacement of @entity4 with whole grains was associated with a lower @entity5 risk.

title: XXXX Consumption and Risk of Type 2 @entity2 : Results from Three Prospective Cohort Studies.

answer: @entity4


abstract: BACKGROUND: @entity6 are supportive in the regulation and modulation of various physiological processes in body, they acts as precursors in nucleic acid synthesis, enhance immune response, help in absorption of @entity0 and influence the metabolism of @entity3 . Cordyceps sinensis and Ganoderma lucidum are well-known for its use in traditional medicine of China, Nepal and India. They are rich in @entity6 such as @entity7 , @entity1 , @entity4 , etc. Hence, a simple, economic and accurate high-performance liquid chromatography (HPLC) analytical method was proposed for determination of @entity7 and @entity1 for the quality control of plants. MATERIALS AND METHODS: Chromatographic experiments were conducted on YL9100 HPLC system (South Korea). Reversed-phase chromatography was performed on a C18 column with @entity2 and @entity8 as the mobile phase in isocratic elution method at a flow rate of 1.0 mL/min. Detection was carried out at 254 nm, which gives a sharp peak of @entity7 and @entity1 at a retention time of 6.53    0.02 min and 12.41    0.02, respectively. RESULTS AND DISCUSSION: Linear regression analysis data for the calibration plot showed a good linear relationship between response and concentration in the range of 25-200   g/mL for @entity1 and 100-800   g/mL for @entity7 with regression coefficient of 0.999 and 0.996, respectively. The @entity7 was found 0.16% and 0.71% w/w in G. lucidum and in @entity5 , respectively, and @entity1 was found to be 0.14% w/w in G. lucidum whereas absent in @entity5 . CONCLUSION: The developed HPLC method for the quantification of @entity1 and @entity7 can be used for the quality control and standardization of crude drug and for the different herbal formulations, in which @entity7 and @entity1 are present as major constituents. The wide linearity range, sensitivity, accuracy, and simple mobile phase imply the method is suitable for routine quantification of @entity1 and @entity7 with high precision and accuracy.

title: Determination of XXXX in Cordyceps sinensis and Ganoderma lucidum by high performance liquid chromatography method.

answer: @entity6


abstract: BACKGROUND: Adolescent @entity4 is the most common type of @entity1 , and whilst the isk of progression appears to be biomechanically mediated (larger deformities are more likely to progress), the detailed biomechanical mechanisms driving progression are not well understood. Gravitational forces in the upright position are the primary sustained loads experienced by the spine. In @entity3 they are asymmetrical, generating moments about the @entity5 which may promote asymmetrical growth and @entity1 . Using 3D imaging modalities to estimate segmental torso masses allows the gravitational loading on the scoliotic spine to be determined. The resulting distribution of joint moments aids understanding of the mechanics of @entity3 progression. METHODS: Existing low-dose CT scans were used to estimate torso segment masses and joint moments for 20 female @entity3 @entity0 . Intervertebral joint moments at each vertebral level were found by summing the moments of each of the torso segment masses above the required joint. RESULTS: The @entity0 ' mean age was 15.3  years ( @entity2 2.3; range 11.9-22.3  years); mean thoracic major Cobb angle 52(  ) ( @entity2 5.9(  ); range 42-63(  )) and mean weight 57.5  kg ( @entity2 11.5  kg; range 41-84.7  kg). Joint moments of up to 7  Nm were estimated at the apical level. No significant correlation was found between the @entity0 ' major Cobb angles and apical joint moments. CONCLUSIONS: @entity0 with larger Cobb angles do not necessarily have higher joint moments, and curve shape is an important determinant of joint moment distribution. These findings may help to explain the variations in progression between individual @entity0 . This study suggests that substantial corrective forces are required of either internal instrumentation or orthoses to effectively counter the gravity-induced moments acting to deform the @entity5 of @entity4 @entity0 .

title: Gravity-induced XXXX in adolescent idiopathic scoliosis.

answer: @entity5


abstract: OBJECTIVES: ABC transporters, @entity6 , @entity5 , @entity8 and @entity7 , can bind both endo- and exogenous ligands. The latter include immunosuppressive, anticancer sedative, anticonvulsant, antiparasitic and cardiovascular drugs, as well as @entity2 protease inhibitors and antibiotics. Protein transporters are also involved in tissue distribution of orally administered medicines in combination therapy for @entity1 ( @entity1 ) and could be used during @entity1 treatment. The distribution depends on transporter specificity its expression and subcellular localization. THE AIM: The aim of the study was to compare @entity6 , @entity5 , @entity8 and @entity7 localization in placental tissues from normal and @entity1 . MATERIAL AND METHODS: Tissue samples were taken from 10 normal and 10 @entity1 placentas. Immunohistochemical reactions were performed with the use of adequate monoclonal antibodies. Avidin- @entity3 -peroxidase complex method was used for the visualization of antigen-antibody complexes. RESULTS: @entity6 , @entity5 and @entity8 were found in all parts of normal @entity0 placenta i.e. the @entity4 epithelium, cytotrophoblast, syncytiotrophoblast and decidual cells. @entity6 and @entity8 , but not @entity5 and @entity7 , were also localized on the endothelial cells of fetal blood vessels in the chorionic plate, as well as stem and tertiary villi. @entity7 expression was observed in the cytotrophoblast and the syncytiotrophoblast. Its expression was very low or undetectable in the @entity4 epithelium and the majority of decidual cells. Immunohistochemical reactions within the syncytiotrophoblast showed apical ( @entity6 , @entity8 ), apical and basal ( @entity7 ) or diffuse ( @entity5 ) distribution. The main changes observed in @entity1 placentas included weaker @entity7 and @entity5 positive reactions in the syncytiotrophoblast, slightly lower expression of @entity6 in the decidual and @entity4 epithelial cells, and @entity5 in the @entity4 epithelium. CONCLUSIONS: Our results indicate that @entity1 -related changes in the environment of placental cells do not substantially influence tissue and subcellular location of ABC transporters. Nevertheless, the expression of @entity6 , @entity5 and @entity7 may be lower in comparison to normal placentas. Basal syncytiotrophoblast transporters, @entity7 and @entity5 , seem to be more sensitive to the influence of @entity1 than apical proteins, what may result in altered biodisposition of endogenous substrates and drugs.

title: Immunolocalization of ABC drug transporters in @entity0 placenta from normal and gestational XXXX .

answer: @entity1


abstract: OBJECTIVES: ABC transporters, @entity6 , @entity5 , @entity8 and @entity7 , can bind both endo- and exogenous ligands. The latter include immunosuppressive, anticancer sedative, anticonvulsant, antiparasitic and cardiovascular drugs, as well as @entity2 protease inhibitors and antibiotics. Protein transporters are also involved in tissue distribution of orally administered medicines in combination therapy for @entity1 ( @entity1 ) and could be used during @entity1 treatment. The distribution depends on transporter specificity its expression and subcellular localization. THE AIM: The aim of the study was to compare @entity6 , @entity5 , @entity8 and @entity7 localization in placental tissues from normal and @entity1 . MATERIAL AND METHODS: Tissue samples were taken from 10 normal and 10 @entity1 placentas. Immunohistochemical reactions were performed with the use of adequate monoclonal antibodies. Avidin- @entity3 -peroxidase complex method was used for the visualization of antigen-antibody complexes. RESULTS: @entity6 , @entity5 and @entity8 were found in all parts of normal @entity0 placenta i.e. the @entity4 epithelium, cytotrophoblast, syncytiotrophoblast and decidual cells. @entity6 and @entity8 , but not @entity5 and @entity7 , were also localized on the endothelial cells of fetal blood vessels in the chorionic plate, as well as stem and tertiary villi. @entity7 expression was observed in the cytotrophoblast and the syncytiotrophoblast. Its expression was very low or undetectable in the @entity4 epithelium and the majority of decidual cells. Immunohistochemical reactions within the syncytiotrophoblast showed apical ( @entity6 , @entity8 ), apical and basal ( @entity7 ) or diffuse ( @entity5 ) distribution. The main changes observed in @entity1 placentas included weaker @entity7 and @entity5 positive reactions in the syncytiotrophoblast, slightly lower expression of @entity6 in the decidual and @entity4 epithelial cells, and @entity5 in the @entity4 epithelium. CONCLUSIONS: Our results indicate that @entity1 -related changes in the environment of placental cells do not substantially influence tissue and subcellular location of ABC transporters. Nevertheless, the expression of @entity6 , @entity5 and @entity7 may be lower in comparison to normal placentas. Basal syncytiotrophoblast transporters, @entity7 and @entity5 , seem to be more sensitive to the influence of @entity1 than apical proteins, what may result in altered biodisposition of endogenous substrates and drugs.

title: Immunolocalization of ABC drug transporters in XXXX placenta from normal and gestational @entity1 .

answer: @entity0


abstract: UNASSIGNED: Comparative enzymology explores the molecular mechanisms that alter the properties of enzymes to best fit and adapt them to the biotic demands and abiotic stresses that affect the cellular environment in which these protein catalysts function. For many years, comparative enzymology was primarily concerned with analyzing enzyme functional properties (e.g. substrate affinities, allosteric effectors, responses to temperature or pH, stabilizers, denaturants, etc.) in order to determine how enzyme properties were optimized to function under changing conditions. More recently it became apparent that posttranslational modifications of enzymes play a huge role in metabolic regulation. At first, such modifications appeared to target just crucial regulatory enzymes but recent work is showing that many dehydrogenases are also targets of posttranslational modification leading to substantial changes in enzyme properties. The present article focuses in particular on @entity1 dehydrogenase (LDH) showing that stress-induced changes in enzyme properties can be linked with reversible posttranslational modifications; e.g. changes in the phosphorylation state of LDH occur in response to @entity2 stress in frogs and @entity0 exposure of turtles and snails. Furthermore, these studies show that LDH is also a target of other posttranslational modifications including acetylation, methylation and ubiquitination that change in response to @entity0 or @entity2 stress. Selected new methods for exploring posttranslational modifications of dehydrogenases are discussed and new challenges for the future of comparative enzymology are presented that will help to achieve a deeper understanding of biochemical adaptation through enzyme regulation.

title: Comparative enzymology-new insights from studies of an "old" enzyme, XXXX dehydrogenase.

answer: @entity1


abstract: OBJECTIVE: To study the effects of transcutaneous electrical nerve stimulation on multimodal @entity4 after total knee arthroplasty. METHODS: Sixty @entity0 diagnosed as @entity2 and suffered unilateral total knee arthroplasty in the department of orthopedics, Zhejiang Traditional Chinese Medicine Hospital from March 2009 to May 2012 were randomly divided into control group and test group, 30 cases in each group. All the @entity0 received @entity7 preoperatively, knee periarticular injection with the drug mixture intraoperatively, and @entity7 and @entity3 controlled-release tablets postoperatively. The @entity0 in the test group were also treated with transcutaneous electrical nerve stimulation each day after operation. All the @entity0 started doing functional exercises at 24 h after operation. Postoperative visual analogue scales(VAS), @entity5 were recorded. RESULTS: The VAS scores of test group during postoperative 24 h to 1 week were 3.39 +/- 0.69, 2.79 +/- 0.51, 2.16 +/- 0.52, and 1.07 +/- 0.57 separately,which were lower than 3.80 +/- 0.86, 3.22 +/- 0.58, 2.53 +/- 0.54 and 1.38 +/- 0.52 in the control group. The passive and active range of knee joint motion in the test group during postoperative 24 h to 2 weeks were (30.67 +/- 3.65) degrees, (39.17 +/- 3.96) degrees, (47.83 +/- 4.86) degrees, (93.67 +/- 7.30) degrees, (107.67 +/- 7.51) degrees and (29.83 +/- 5.33) degrees, (78.33 +/- 8.24) degrees, (95.17 +/- 5.94) degrees respectively,which were higher than (28.67 +/- 3.92) degrees, (36.83 +/- 4.25) degrees, (45.17 +/- 5.17) degrees, (89.83 +/- 7.25) degrees, (103.17 +/- 7.37) degrees and (24.17 +/- 10.26) degrees, (73.83 +/- 9.07) degrees, (91.33 +/- 7.42) degrees in the control group. In the test group, 19 @entity0 had ring-shaped haemostasis impression to some extent in the skin of knee joint to different degree, and 5 @entity0 had @entity6 formation. CONCLUSION: It is meaningful to apply transcutaneous electrical nerve stimulation for treating multimodal @entity4 after total knee arthroplasty,which can not only relieve @entity0 ' @entity1 , and also promote the rehabilitation of knee function as far as possible.

title: [Application of transcutaneous electrical nerve stimulation to multimodal XXXX after total knee arthroplasty].

answer: @entity4


abstract: OBJECTIVE: To study clinical effects of the over-articular external fixator combined with limited internal fixation for the treatment of @entity2 caused by high energy. METHODS: From September 2003 to April 2011, 36 @entity0 with @entity2 caused by high energy were treated with the over-articular external fixator combined with limited internal fixator. There were 25 males and 11 females, ranging in age from 16 to 72 years old,with an average of 38 years old. The diagnoses of all @entity0 were determined by conventional X-ray examination or three-dimensional spiral CT examination. The AOFAS scoring criteria was used to evaluate the therapeutic effects. The @entity0 with comminuted @entity2 were treated with screw or Kirschner wire fixation without uncovering periost so as to enhance stability between @entity2 end and bone blocks,followed by the fixation with over-articular external fixators. RESULTS: All the @entity0 were followed up, and the duration ranged from 4 to 27 months, with an average of 13 months. Thirty-two @entity0 got wound healing at the first stage. And the bone union duration ranged from 2 to 6 months, with a mean of 3 months. According to the AOFAS ankle-hindfoot subjective scoring standard, 13 @entity0 got an excellent result, 20 good and 3 fair, with an score of 88.2 +/- 3.6. Twelve @entity0 had @entity3 at pinhole, 5 @entity0 had @entity1 . One @entity0 had the fixator broken induced by over loading, who was cured after treatment. There were no complications such as nerve or @entity4 , or @entity5 . CONCLUSION: The over-articular external fixation combined with limited internal fixation for the treatment of @entity2 caused by high energy is an ideal method, which has such advantages as reliable fixation, simple operation, coincidence with principles of biomechanical fixation, and benefit for @entity2 healing.

title: [Over-articular external fixator combined with limited internal fixation for the treatment of high-energy XXXX ].

answer: @entity2


abstract: INTRODUCTION: We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive @entity1 species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed @entity5 . The objective of the present study was to demonstrate the superior efficacy of anti-inflammatory cytokines when targeted to inflamed @entity5 by the anti-ROS modified CII (anti-ROS-CII) scFv in a @entity0 model of @entity3 . METHODS: Viral @entity4 (vIL-10) was fused to anti-ROS-CII scFv (1-11E) with a matrix-metalloproteinase (MMP) cleavable linker to create 1-11E/vIL-10 fusion. Binding of 1-11E/vIL-10 to ROS-CII was determined by enzyme-linked immunosorbent assay (ELISA), Western blotting, and immune-staining of arthritic cartilage, whereas vIL-10 bioactivity was evaluated in vitro by using an @entity0 cell-proliferation assay. Specific in vivo localization and therapeutic efficacy of 1-11E/vIL-10 was tested in the @entity0 model of antigen-induced @entity3 . RESULTS: 1-11E/vIL-10 bound specifically to ROS-CII and to damaged arthritic cartilage. Interestingly, the in vitro vIL-10 activity in the fusion protein was observed only after cleavage with @entity6 . When systemically administered to arthritic @entity0 , 1-11E/vIL-10 localized specifically to the arthritic knee, with peak accumulation observed after 3 days. Moreover, 1-11E/vIL-10 reduced @entity2 significantly quicker than vIL-10 fused to the control anti-hen egg lysozyme scFv (C7/vIL10). CONCLUSIONS: Targeted delivery of anti-inflammatory cytokines potentiates their anti-arthritic action in a @entity0 model of @entity3 . Our results further support the hypothesis that targeting biotherapeutics to @entity5 may be extended to include anti-inflammatory cytokines that lack efficacy when administered systemically.

title: Targeting of viral XXXX with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency.

answer: @entity4


abstract: Background. The aims of the study were to determine the incidence rate of pediatric @entity1 (PIBD) and its trends for the period of 2002-2010 and to assess the geographical distribution of PIBD in Slovenia. Materials and Methods. Medical records of @entity0 (0-18 years) with newly diagnosed @entity4 during the study period were retrospectively reviewed. Results. The mean incidence rate for @entity4 in 2002-2010 was 7.6 per 100,000 @entity0 and adolescents per year, 4.5 for @entity2 ( @entity2 ), 2.9 for @entity3 ( @entity3 ), and 0.2 for @entity4 -unclassified, respectively. The incidence rate increased from 5.8 per 100,000 per year in 2002-2004 to 8.6 in 2005-2007 and remained stable afterwards. Statistically significant difference in the incidence rate between the Northeastern and Southwestern parts of the country was observed (p = 0.025). Conclusion. This nationwide study demonstrates that Slovenia is among the European countries with the highest PIBD incidence. During the study period a substantial rise of PIBD incidence was observed during the first half of the study and it seems to have stabilized in the second half. The significant difference in PIBD incidence between Northeastern and Southwestern parts of the country merits further exploration of the possible environmental factors.

title: Incidence Trends and Geographical Variability of Pediatric XXXX in Slovenia: A Nationwide Study.

answer: @entity1


abstract: BACKGROUND: A greater burden of @entity3 risk factors in general is associated with a higher risk for @entity3 among @entity0 of lower than those of higher socioeconomic position. The relative impact of individual @entity3 risk factors is still unclear. METHODS AND RESULTS: We studied the relations between socioeconomic position, measured as household income and length of education, and all hospital admissions for a first @entity7 among 54 048 @entity0 over the age of 40 years in Denmark in 2003-2012 in comparison with the general Danish population (23.5 million @entity0 -years). We also studied the @entity4 factor profile associated with socioeconomic position in @entity3 @entity0 . Relative risks for @entity3 were estimated in log-linear Poisson regression models. The risk for hospitalization for a first @entity7 was almost doubled for @entity0 in the lowest income group, and the risk of those of working age (<65 years) was increased by 36% among @entity0 with the shortest education. @entity1 , @entity2 , smoking, and high @entity6 consumption in particular and, to a lesser extent, previous @entity8 or intermittent arterial claudication were significantly overrepresented among @entity3 @entity0 with lower socioeconomic position. @entity9 and @entity5 were not. CONCLUSIONS: In Denmark, there is a strong relation between low socioeconomic position and risk for hospitalization for @entity3 . Lifestyle, as indicated by smoking, @entity2 , and @entity6 consumption, and @entity1 appears to increase the risk for @entity3 in @entity0 with lower socioeconomic position.

title: Socioeconomic position and incidence of XXXX in denmark 2003-2012. A nationwide hospital-based study.

answer: @entity7


abstract: AIM: To assess complex radiodiagnosis and highly specialized medical care as knee joint replacement (KJR) to @entity0 with @entity5 ( @entity5 ) who live in the Republic of Kazakhstan. SUBJECTS AND METHODS: The results of examination and treatment were analyzed in 40 @entity0 with knee @entity5 who were treated at the specialized Polytrauma Unit, Republican Research Center for Emergency Health Care. All @entity0 with @entity2 underwent joint X-ray study, computed tomography and magnetic resonance imaging (MRI), X-ray densitometry and ultrasound osteometry on admission and after KJR. RESULTS: Joint X-ray studies and computed tomography revealed that all the @entity0 had Grades II-III arthroses with severe @entity5 , their multiple involvements of different grades, which depended on the rate of recurrent @entity6 . Ultrasound study (USS) is the only mini-invasive method to control surgical hemostasis in hemophiliac @entity0 after KJR. Osteodensitometry revealed @entity4 and @entity1 in all the @entity0 with @entity2 , which was a basis for prescribing @entity3 preparations in the early postoperative period for the prevention of instability of endoprosthetic components. We elaborated an algorithm for combination treatment in @entity5 @entity0 , which involved knee joint replacement. CONCLUSION: Highly specialized medical care to hemophilic @entity0 and active introduction of the early surgical rehabilitation of the affected joint in their combination treatment contributed to the increased number of positive results, by restoring the quality of life in the @entity0 : excellent, good, and satisfactory anatomic and functional results were obtained in 26.7, 51.1, and 22.2%, respectively. USS and MRI could evaluate joint changes in @entity5 in detail, which plays an important role in the estimation of the course time of the disease, in the planning of endoprosthetic replacement, and in the timely prevention of severe complications of @entity5 . Osteodensitometry makes it possible to monitor bone mineral density around the prosthesis and to postoperatively prevent endoprosthetic instability.

title: [Radiodiagnosis and knee joint replacement in XXXX in Kazakhstan residents].

answer: @entity5


abstract: OBJECTIVE: Surgical treatment of @entity2 ( @entity2 ) has evolved over the previous 2 decades to a predominantly endoscopic approach. In this study, we review our experience with endoscopic staple-assisted diverticulostomy (ESD) for treatment of @entity2 from 2002 to 2011. METHODS: Retrospective chart review of 359 primary and revision ESD procedures performed on 337 unique @entity0 between September 2002 and December 2011. Data were tabulated for age, sex, size of diverticulum, time to symptom recurrence, complications, and relief of symptoms. RESULTS: Of 337 attempted primary ESD procedures, 3.9% (N = 13) were aborted due to inadequate exposure. Of 324 @entity0 who underwent primary ESD, 93.8% (N = 304) reported postoperative improvement of @entity1 symptoms. There was a 4.0% (N = 13) major complication rate. @entity0 -reported recurrence of symptoms occurred in 7.1% (N = 23) of primary ESD @entity0 but was not significantly associated with diverticulum size (P = .9765). Twenty-one @entity0 underwent revision ESD, with 95% (N = 20) of @entity0 reporting improvement and 4.8% (N = 1) developing recurrent symptoms. CONCLUSION: Primary and revision ESD were shown to have similar success at relieving the symptoms of @entity2 , with low procedure abandonment and perioperative complication rates. Further @entity0 follow-up is needed to determine the durability of symptom improvement and @entity2 recurrence rate following ESD.

title: Endoscopic Staple Diverticulostomy for XXXX : Review of Experience in 337 Cases.

answer: @entity2


abstract: OBJECTIVES: In 2010, a new TNM staging system was published by American Joint Committee on Cancer, changing the nodal classification to include the presence of common iliac lymph node (LN) involvement as N3 category. The objective of this study was to define the capability of the current TNM nodal classification to separate @entity0 with different prognostic stages and to evaluate the effect of @entity4 burden. METHODS AND MATERIALS: A total of 93 @entity0 with metastatic LNs after radical cystectomy and extended LN dissection for @entity2 of the bladder between 1999 and 2012 were included. The median follow-up was 21.5 months. The correlation between N3 and indicators of @entity4 burden was analyzed using the Spearman correlation coefficient. @entity3 ( @entity3 ) and @entity3 ( @entity3 ) analysis was performed using the Kaplan-Meier and Cox proportional hazards methods. RESULTS: The presence of N3 disease was associated with higher number of metastatic LNs (7 vs. 2, P<0.01); however, this was highly variable and correlation coefficients between common iliac metastatic LNs and other @entity5 burden indicators demonstrated weak association (0.39-0.63). @entity0 with N1 lesions were found to have a distinct @entity3 and @entity3 (P<0.01 and P = 0.01, respectively). A trend toward worse @entity3 (P = 0.07) and @entity3 (P = 0.08) was observed in @entity0 with N3 lesions. However, no difference in @entity3 or @entity3 was found between @entity0 with N2 and N3 lesions (P = 0.83 and 0.50, respectively). CONCLUSIONS: The N3 category in the current TNM classification defines a group of @entity0 with high but heterogeneous disease burden. This may be the explanation for its lack of prognostic stratification when compared with N2 category @entity1 .

title: Critical analysis of the 2010 TNM classification in @entity0 with XXXX : Influence of @entity4 burden.

answer: @entity1


abstract: OBJECTIVES: In 2010, a new TNM staging system was published by American Joint Committee on Cancer, changing the nodal classification to include the presence of common iliac lymph node (LN) involvement as N3 category. The objective of this study was to define the capability of the current TNM nodal classification to separate @entity0 with different prognostic stages and to evaluate the effect of @entity4 burden. METHODS AND MATERIALS: A total of 93 @entity0 with metastatic LNs after radical cystectomy and extended LN dissection for @entity2 of the bladder between 1999 and 2012 were included. The median follow-up was 21.5 months. The correlation between N3 and indicators of @entity4 burden was analyzed using the Spearman correlation coefficient. @entity3 ( @entity3 ) and @entity3 ( @entity3 ) analysis was performed using the Kaplan-Meier and Cox proportional hazards methods. RESULTS: The presence of N3 disease was associated with higher number of metastatic LNs (7 vs. 2, P<0.01); however, this was highly variable and correlation coefficients between common iliac metastatic LNs and other @entity5 burden indicators demonstrated weak association (0.39-0.63). @entity0 with N1 lesions were found to have a distinct @entity3 and @entity3 (P<0.01 and P = 0.01, respectively). A trend toward worse @entity3 (P = 0.07) and @entity3 (P = 0.08) was observed in @entity0 with N3 lesions. However, no difference in @entity3 or @entity3 was found between @entity0 with N2 and N3 lesions (P = 0.83 and 0.50, respectively). CONCLUSIONS: The N3 category in the current TNM classification defines a group of @entity0 with high but heterogeneous disease burden. This may be the explanation for its lack of prognostic stratification when compared with N2 category @entity1 .

title: Critical analysis of the 2010 TNM classification in @entity0 with @entity1 : Influence of XXXX burden.

answer: @entity4


abstract: OBJECTIVES: In 2010, a new TNM staging system was published by American Joint Committee on Cancer, changing the nodal classification to include the presence of common iliac lymph node (LN) involvement as N3 category. The objective of this study was to define the capability of the current TNM nodal classification to separate @entity0 with different prognostic stages and to evaluate the effect of @entity4 burden. METHODS AND MATERIALS: A total of 93 @entity0 with metastatic LNs after radical cystectomy and extended LN dissection for @entity2 of the bladder between 1999 and 2012 were included. The median follow-up was 21.5 months. The correlation between N3 and indicators of @entity4 burden was analyzed using the Spearman correlation coefficient. @entity3 ( @entity3 ) and @entity3 ( @entity3 ) analysis was performed using the Kaplan-Meier and Cox proportional hazards methods. RESULTS: The presence of N3 disease was associated with higher number of metastatic LNs (7 vs. 2, P<0.01); however, this was highly variable and correlation coefficients between common iliac metastatic LNs and other @entity5 burden indicators demonstrated weak association (0.39-0.63). @entity0 with N1 lesions were found to have a distinct @entity3 and @entity3 (P<0.01 and P = 0.01, respectively). A trend toward worse @entity3 (P = 0.07) and @entity3 (P = 0.08) was observed in @entity0 with N3 lesions. However, no difference in @entity3 or @entity3 was found between @entity0 with N2 and N3 lesions (P = 0.83 and 0.50, respectively). CONCLUSIONS: The N3 category in the current TNM classification defines a group of @entity0 with high but heterogeneous disease burden. This may be the explanation for its lack of prognostic stratification when compared with N2 category @entity1 .

title: Critical analysis of the 2010 TNM classification in XXXX with @entity1 : Influence of @entity4 burden.

answer: @entity0


abstract: OBJECTIVES: To explore the potential prognostic significance of the lymphocyte-monocyte ratio (LMR) in @entity0 with nonmetastatic @entity4 ( @entity4 ), as the LMR has been repeatedly proposed to have a negative effect on @entity0  s survival in various hematological and solid @entity2 . However, findings about LMR  s prognostic significance in @entity4 have not been reported yet. METHODS AND MATERIALS: We retrospectively evaluated the prognostic significance of the LMR in a cohort comprising 678 @entity0 with nonmetastatic clear cell @entity4 , who were operated between 2000 and 2010 with curative radical or partial nephrectomy at a single tertiary academic center. Preoperative LMR was calculated 1 day before surgical intervention. @entity0 were categorized using an LMR cutoff of 3.0. Cancer-specific survival (CSS), @entity1 -free survival, and overall survival were assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the LMR, multivariate Cox regression models were applied. Additionally, the influence of the LMR on the predictive accuracy of the Leibovich prognosis score was determined using the Harrell concordance index (c-index) and decision curve analysis. RESULTS: Low LMR was statistically significantly associated with older @entity0 (>= 65y), high @entity2 grade (G3+G4), advanced pathologic T category ( @entity5 +pT4), the presence of histologic @entity2 @entity3 , and male gender (P<0.05). Multivariate analysis identified a low LMR as an independent prognostic factor for @entity0   CSS (hazard ratio = 2.33; 95% CI: 1.10-4.94; P = 0.027). The estimated c-index was 0.83 using the Leibovich prognosis score and 0.86 when the LMR was added. CONCLUSIONS: Regarding CSS of @entity0 with @entity4 , a decreased LMR represents an independent prognostic factor. Adding the LMR to well-established prognostic models, such as the Leibovich prognosis score, might improve their predictive ability.

title: Low preoperative lymphocyte-monocyte ratio (LMR) represents a potentially poor prognostic factor in nonmetastatic XXXX .

answer: @entity4


abstract: PURPOSE: Prior studies have suggested that @entity4 PET/CT can help characterize @entity2 and differentiate adrenal metastases from benign lesions. The aim of this study was to assess the value of @entity4 PET/CT for the differentiation of malignant from benign @entity2 . METHODS: This retrospective study included 85 @entity0 (47 @entity0 and 38 @entity0 , age 63.8        10.8  years) who had undergone @entity4 PET/CT (60  min after injection 300  -  370  MBq @entity4 ; Biograph 64 scanner) for evaluation of 102 nonsecreting @entity5 . For semiquantitative analysis, the maximum standardized uptake value (SUVmax), adrenal to liver (T/L) SUVmax ratio, mean CT attenuation value and @entity1 diameter were measured in all lesions and compared with the pathological findings. RESULTS: @entity1 (68  % of evaluated @entity1 ) had a significantly higher mean SUVmax (13.0        7.1 vs. 3.7        3.0), a higher T/L SUVmax ratio (4.2        2.6 vs. 1.0        0.9), a higher CT attenuation value (31.9        16. 7  HU vs. 0.2        25.8  HU) and a greater diameter (43.6        23.7  mm vs. 25.6        13.3  mm) than benign lesions. The false-positive findings were @entity3 and @entity1 . Based on ROC analysis, a T/L SUVmax ratio >1.53, an adrenal SUVmax >5.2, an attenuation value >24  HU and a @entity1 diameter >30  mm were chosen as the optimal cut-off values for differentiating @entity1 . The areas under the ROC curves for the selected cut-off values were 0.96, 0.96, 0.88 and 0.77, respectively. A multivariate logistic regression model revealed that the T/L SUVmax ratio was an independent prognostic factor for @entity1 (p   <   0.001); a CT attenuation value of >25 HU and a @entity1 diameter >30  mm had no additional individual importance in the diagnosis of @entity1 . CONCLUSION: Using a T/L SUVmax ratio >1.53 and an adrenal SUVmax >5.2 in @entity4 PET/CT led to high diagnostic sensitivity, specificity and negative predictive value for characterizing @entity1 . The diagnostic accuracies of the two parameters were comparable, but T/L SUVmax ratio was an independent predictor of @entity1 .

title: What parameters from XXXX PET/CT are useful in evaluation of @entity2 ?

answer: @entity4


abstract: PURPOSE: Prior studies have suggested that @entity4 PET/CT can help characterize @entity2 and differentiate adrenal metastases from benign lesions. The aim of this study was to assess the value of @entity4 PET/CT for the differentiation of malignant from benign @entity2 . METHODS: This retrospective study included 85 @entity0 (47 @entity0 and 38 @entity0 , age 63.8        10.8  years) who had undergone @entity4 PET/CT (60  min after injection 300  -  370  MBq @entity4 ; Biograph 64 scanner) for evaluation of 102 nonsecreting @entity5 . For semiquantitative analysis, the maximum standardized uptake value (SUVmax), adrenal to liver (T/L) SUVmax ratio, mean CT attenuation value and @entity1 diameter were measured in all lesions and compared with the pathological findings. RESULTS: @entity1 (68  % of evaluated @entity1 ) had a significantly higher mean SUVmax (13.0        7.1 vs. 3.7        3.0), a higher T/L SUVmax ratio (4.2        2.6 vs. 1.0        0.9), a higher CT attenuation value (31.9        16. 7  HU vs. 0.2        25.8  HU) and a greater diameter (43.6        23.7  mm vs. 25.6        13.3  mm) than benign lesions. The false-positive findings were @entity3 and @entity1 . Based on ROC analysis, a T/L SUVmax ratio >1.53, an adrenal SUVmax >5.2, an attenuation value >24  HU and a @entity1 diameter >30  mm were chosen as the optimal cut-off values for differentiating @entity1 . The areas under the ROC curves for the selected cut-off values were 0.96, 0.96, 0.88 and 0.77, respectively. A multivariate logistic regression model revealed that the T/L SUVmax ratio was an independent prognostic factor for @entity1 (p   <   0.001); a CT attenuation value of >25 HU and a @entity1 diameter >30  mm had no additional individual importance in the diagnosis of @entity1 . CONCLUSION: Using a T/L SUVmax ratio >1.53 and an adrenal SUVmax >5.2 in @entity4 PET/CT led to high diagnostic sensitivity, specificity and negative predictive value for characterizing @entity1 . The diagnostic accuracies of the two parameters were comparable, but T/L SUVmax ratio was an independent predictor of @entity1 .

title: What parameters from @entity4 PET/CT are useful in evaluation of XXXX ?

answer: @entity2


abstract: PURPOSE/OBJECTIVE(S): Primary low-grade @entity2 are common @entity5 of childhood, many of which require radiation therapy (RT) as definitive treatment. Increased conformality of RT could decrease the incidence and severity of late effects. We report our experience with 32 pediatric @entity0 treated with @entity4 . METHODS AND MATERIALS: Thirty-two pediatric @entity0 with low-grade @entity3 or spinal cord were treated with @entity4 from 1995 to 2007. Sixteen @entity0 received at least 1 regimen of chemotherapy before definitive RT. The median radiation dose was 52.2 GyRBE (48.6-54 GyRBE). RESULTS: The median age at treatment was 11.0 years (range, 2.7-21.5 years), with a median follow-up time of 7.6 years (range, 3.2-18.2 years). The 6-year and 8-year rates of progression-free survival were 89.7% and 82.8%, respectively, with an 8-year overall survival of 100%. For the subset of @entity0 who received serial neurocognitive testing, there were no significant declines in Full-Scale Intelligence Quotient (P=.80), with a median neurocognitive testing interval of 4.5 years (range, 1.2-8.1 years) from baseline to follow-up, but subgroup analysis indicated some significant decline in neurocognitive outcomes for young @entity0 (<7 years) and those with significant dose to the left temporal lobe/hippocampus. The incidence of @entity7 correlated with a mean dose of >= 40 GyRBE to the hypothalamus, pituitary, or optic chiasm. Stabilization or improvement of visual acuity was achieved in 83.3% of @entity0 at risk for radiation-induced @entity8 . CONCLUSIONS: This report of late effects in @entity0 with low-grade @entity2 after @entity4 is encouraging. Proton RT appears to be associated with good clinical outcome, especially when the @entity1 location allows for increased sparing of the left temporal lobe, hippocampus, and @entity6 .

title: Clinical outcomes and late endocrine, neurocognitive, and visual profiles of proton radiation for pediatric low-grade XXXX .

answer: @entity2


abstract: @entity4 is a multiorgan @entity6 caused by the spirochete @entity2 . This case series highlights its presence in Haryana, a nonendemic zone. The first case was a 27-year-old housewife who presented with an annular erythematous patch with a central papule following an insect bite on the left upper arm. The second case was a 32-year-old farmer who gave a history of insect bite on the right arm followed by the development of an erythematous patch with a central blister. The third case, a 17-year-old @entity0 presented with a history of @entity7 over right thigh and a typical bull's @entity3 with central ulceration. These cases were managed with oral @entity5 100 mg twice daily for 14 days. The fourth case was a 7-year-old @entity0 with typical @entity8 on the right check and neck while the fifth case, a 30-year-old housewife, presented with an erythematous patch with a central papule on the right buttock. These @entity0 were treated with oral @entity1 25 mg/kg, thrice daily for 14 days. All @entity0 showed IgM antibodies to @entity2 . Treatment led to clearance of lesions in all the @entity0 . @entity4 was diagnosed in these @entity0 based on the history of established exposure to tick bites, presence of classic signs and symptoms, serology and the response to treatment.

title: XXXX in Haryana, India.

answer: @entity4


abstract: @entity2 ( @entity2 ) refers to @entity2 attributed to muscle and its surrounding fascia, which is associated with "myofascial trigger points" (MTrPs). MTrPs in the trapezius has been proposed as the main cause of temporal and cervicogenic @entity0 and @entity4 . Literature shows that the prevalence of various @entity1 ( @entity1 ) among physiotherapists is high. Yoga has traditionally been used to treat MSDs in various populations. But there is scarcity of literature which explains the effects of yoga on reducing @entity2 of the neck in terms of various physical parameters and subjective responses. Therefore, a pilot study was done among eight physiotherapists with minimum six months of experience. A structured yoga protocol was designed and implemented for five days in a week for four weeks. The outcome variables were Disability of Arm, Shoulder and Hands (DASH) score, @entity3 ( @entity3 ), Visual Analogue Scale (VAS), Pressure @entity2 Threshold (PPT) for Trigger Points, Cervical Range of Motion (CROM) - active _ passive, grip and pinch strengths. The variables were compared before and after the intervention. Finally, the result revealed that all the variables (DASH: P<0.00, @entity3 : P<0.00, VAS: P<0.00, PPT: Left: P<0.00, PPT: Right: P<0.00, Grip strength: left: P<0.00, Grip strength: right: P<0.01, Key pinch: left: P<0.01, Key pinch: right: P<0.01, @entity5 : left: P<0.01, @entity5 : right: P<0.00, Tip pinch: left: P<0.01, Tip pinch: Right: P<0.01) improved significantly after intervention.

title: Effect of yoga on the XXXX .

answer: @entity4


abstract: PURPOSE: To assess if a formal 2-week hand therapy improves outcomes and justifies its expense. METHODS: A prospective randomized study was completed using a contemporary short incision and a 2-week program of therapy. @entity0 were randomized into 2 treatment groups: one group received instruction on home therapy exercises to be followed after @entity3 release, and a second group received the home program in addition to a therapist-directed program for 2 weeks. Variables measured were @entity0 age, gender, preoperative and @entity2 scores, grip and pinch strengths, return to modified and regular work, insurance coverage, and job category. Both groups were followed for 6 months postoperatively. RESULTS: One hundred fifty @entity0 (110 @entity0 and 40 @entity0 ) entered and completed the study. The average age was 46 years (range, 29-70 years). The average age, gender distribution, insurance coverage, and breakdown of job categories between groups was not statistically significant. There was no difference in return to work times between those with and without postoperative therapy; however, @entity0 covered by workers' compensation insurance were slower to return to both modified and regular work compared with the other groups. The postoperative grip and pinch strengths, @entity1 and Disabilities of the Arm, Shoulder, and Hand scores did not show statistical differences between groups at any of the measured time periods. Depending on insurance carrier, directed therapy added  600 to  900 to the cost of care. CONCLUSIONS: The current randomized study failed to show benefit in a 2-week course of hand therapy after @entity3 release using a short incision. The cost of supervised therapy for an uncomplicated @entity3 release seems unjustified.

title: Outcomes of XXXX surgery with and without supervised postoperative therapy.

answer: @entity3


abstract: PURPOSE: To determine the effectiveness of a protocol for the treatment of @entity1 of the elbow based on the concept that, if @entity3 with associated @entity1 can be made to resemble a simple @entity3 by repairing or reconstructing the fractured structures, repair of the @entity5 ( @entity5 ) will not be necessary. METHODS: Over a 5-year period, a single surgeon operated on 34 @entity0 with a @entity3 associated with one or more @entity4 . The mean age of these 19 @entity0 and 15 @entity0 was 48 years. Associated @entity1 included the capitellum, trochlea, and lateral epicondyle in 3 @entity0 ; the olecranon in 1 @entity0 ; and the radial head in 30 @entity0 (with concomitant @entity1 of the coronoid process-the so-called "terrible triad" of the elbow-in 22 @entity0 , and concomitant @entity1 of the coronoid and olecranon in 1 @entity0 ). Operative treatment consisted of open reduction internal fixation (ORIF) or prosthetic replacement of all @entity1 and reattachment of the origin of the lateral collateral ligament (LCL) complex to the lateral epicondyle. The @entity5 was not repaired. RESULTS: Two @entity0 (1 with a terrible triad injury and 1 with @entity1 of the capitellum and trochlea) had postoperative instability related to noncompliance, had reconstructive procedures, and were considered failures. An average of 32 months after injury, the remaining 32 @entity0 regained an average of 120 degrees ulnohumeral motion and 142 degrees @entity2 . Twenty-five of 34 @entity0 (74%) had good or excellent results according to the system of Broberg and Morrey. @entity0 with terrible triad injuries had an average of 117 degrees ulnohumeral motion and 137 degrees @entity2 , and 17 of 22 @entity0 (77%) had good or excellent results. CONCLUSIONS: @entity5 repair is unnecessary in the treatment of @entity3 with associated @entity4 , provided that the articular @entity1 and the LCL are repaired or reconstructed.

title: @entity3 with XXXX : the results of operative treatment without repair of the @entity5 .

answer: @entity4


abstract: PURPOSE: To determine the effectiveness of a protocol for the treatment of @entity1 of the elbow based on the concept that, if @entity3 with associated @entity1 can be made to resemble a simple @entity3 by repairing or reconstructing the fractured structures, repair of the @entity5 ( @entity5 ) will not be necessary. METHODS: Over a 5-year period, a single surgeon operated on 34 @entity0 with a @entity3 associated with one or more @entity4 . The mean age of these 19 @entity0 and 15 @entity0 was 48 years. Associated @entity1 included the capitellum, trochlea, and lateral epicondyle in 3 @entity0 ; the olecranon in 1 @entity0 ; and the radial head in 30 @entity0 (with concomitant @entity1 of the coronoid process-the so-called "terrible triad" of the elbow-in 22 @entity0 , and concomitant @entity1 of the coronoid and olecranon in 1 @entity0 ). Operative treatment consisted of open reduction internal fixation (ORIF) or prosthetic replacement of all @entity1 and reattachment of the origin of the lateral collateral ligament (LCL) complex to the lateral epicondyle. The @entity5 was not repaired. RESULTS: Two @entity0 (1 with a terrible triad injury and 1 with @entity1 of the capitellum and trochlea) had postoperative instability related to noncompliance, had reconstructive procedures, and were considered failures. An average of 32 months after injury, the remaining 32 @entity0 regained an average of 120 degrees ulnohumeral motion and 142 degrees @entity2 . Twenty-five of 34 @entity0 (74%) had good or excellent results according to the system of Broberg and Morrey. @entity0 with terrible triad injuries had an average of 117 degrees ulnohumeral motion and 137 degrees @entity2 , and 17 of 22 @entity0 (77%) had good or excellent results. CONCLUSIONS: @entity5 repair is unnecessary in the treatment of @entity3 with associated @entity4 , provided that the articular @entity1 and the LCL are repaired or reconstructed.

title: XXXX with @entity4 : the results of operative treatment without repair of the @entity5 .

answer: @entity3


abstract: PURPOSE: To determine the effectiveness of a protocol for the treatment of @entity1 of the elbow based on the concept that, if @entity3 with associated @entity1 can be made to resemble a simple @entity3 by repairing or reconstructing the fractured structures, repair of the @entity5 ( @entity5 ) will not be necessary. METHODS: Over a 5-year period, a single surgeon operated on 34 @entity0 with a @entity3 associated with one or more @entity4 . The mean age of these 19 @entity0 and 15 @entity0 was 48 years. Associated @entity1 included the capitellum, trochlea, and lateral epicondyle in 3 @entity0 ; the olecranon in 1 @entity0 ; and the radial head in 30 @entity0 (with concomitant @entity1 of the coronoid process-the so-called "terrible triad" of the elbow-in 22 @entity0 , and concomitant @entity1 of the coronoid and olecranon in 1 @entity0 ). Operative treatment consisted of open reduction internal fixation (ORIF) or prosthetic replacement of all @entity1 and reattachment of the origin of the lateral collateral ligament (LCL) complex to the lateral epicondyle. The @entity5 was not repaired. RESULTS: Two @entity0 (1 with a terrible triad injury and 1 with @entity1 of the capitellum and trochlea) had postoperative instability related to noncompliance, had reconstructive procedures, and were considered failures. An average of 32 months after injury, the remaining 32 @entity0 regained an average of 120 degrees ulnohumeral motion and 142 degrees @entity2 . Twenty-five of 34 @entity0 (74%) had good or excellent results according to the system of Broberg and Morrey. @entity0 with terrible triad injuries had an average of 117 degrees ulnohumeral motion and 137 degrees @entity2 , and 17 of 22 @entity0 (77%) had good or excellent results. CONCLUSIONS: @entity5 repair is unnecessary in the treatment of @entity3 with associated @entity4 , provided that the articular @entity1 and the LCL are repaired or reconstructed.

title: @entity3 with @entity4 : the results of operative treatment without repair of the XXXX .

answer: @entity5


abstract: @entity5 (CO) is endogenously produced in the @entity0 body, mainly from the oxidation of @entity6 catalyzed by @entity6 oxygenase (HO) enzymes. The induction of HO and the consequent increase in CO production play important physiological roles in vasorelaxation and neurotransmission and in the immune system. The exogenous administration of CO gas and CO-releasing molecules (CO-RMs) has been shown to induce vascular effects and to alleviate @entity2 -reoxygenation injury of @entity0 cells. In particular, due to its anti-inflammatory, antiapoptotic, and antiproliferative properties, CO inhibits @entity7 and provides potent cytoprotective effects during organ and cell transplantation. In spite of these findings regarding the physiology and biology of mammals, nothing is known about the action of CO on bacteria. In the present work, we examined the effect of CO on bacterial cell proliferation. Cell growth experiments showed that CO caused the rapid death of the two pathogenic bacteria tested, @entity3 and @entity4 , particularly when delivered through organometallic CO-RMs. Of importance is the observation that the effectiveness of the CO-RMs was greater in near-anaerobic environments, as many pathogens are anaerobic organisms and pathogen colonization occurs in environments with low @entity1 concentrations. Our results constitute the first evidence that CO can be utilized as an antimicrobial agent. We anticipate our results to be the starting point for the development of novel types of therapeutic drugs designed to combat antibiotic-resistant pathogens, which are widespread and presently a major public health concern.

title: Antimicrobial action of XXXX -releasing compounds.

answer: @entity5


abstract: OBJECTIVE: We wanted to evaluate the role of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for detecting @entity0 , as compared with the T1- and T2-weighted images. MATERIALS AND METHODS: Forty-one female @entity1 underwent breast MRI, and this included the T1-, T2-, DWI and dynamic contrast-enhanced images. Sixty-five enhancing lesions were detected on the dynamic contrast-enhanced images and we used this as a reference image for detecting @entity2 . Fifty-six breast lesions were detected on DWI and the histological diagnoses were as follows: 43 invasive @entity4 , one @entity3 , one mixed @entity5 , seven @entity4 in situ (DCIS), and four @entity2 . First, we compared the detectability of breast lesions on DWI with that of the T1- and T2-weighted images. We then compared the ADCs of the malignant and benign breast lesions to the ADCs of the normal fibroglandular tissue. RESULTS: Fifty-six lesions were detected via DWI (detectability of 86.2%). The detectabilities of breast lesions on the T1- and T2-weighted imaging were 61.5% (40/65) and 75.4% (49/65), respectively. The mean ADCs of the @entity4 (0.89+/-0.18 x 10(-3)mm(2)/second) and DCIS (1.17+/-0.18 x 10(-3)mm(2)/ second) are significantly lower than those of the benign lesions (1.41+/-0.56 x 10(-3)mm(2)/second) and the normal fibroglandular tissue (1.51+/-0.29 x 10(-3)mm(2)/ second). CONCLUSION: DWI has a high sensitivity for detecting @entity0 , and especially for detecting @entity0 . DWI was an effective imaging technique for detecting breast lesions, as compared to using the T1- and T2-weighted images.

title: The role of diffusion-weighted imaging and the apparent diffusion coefficient (ADC) values for XXXX .

answer: @entity0


abstract: PURPOSE: To assess the sterilization effectiveness on uterine tube of @entity0 by the @entity2 adhesive. METHODS: Hysteroscopy tubal catheterization was performed randomly in 12 animals (24 uterine tubes) assigned to the sham group (GS) and 15 animals (30 uterine tubes) to the @entity3 (GB). The female @entity0 were observed during 30, 90 and 180 days and mated to fertile males. The no pregnant @entity0 were submitted to in vitro burst pressure test for patency by air insufflation (40 mmHg). The microscopic assessment was performed to parameters of damages in epithelium caused by the adhesive, the degree of inflammatory process, morphometry data values of tube diameter (UT) (cm), @entity4 ( @entity1 ) (mm). The mucosa cells densitometry (total optical density) was expressed by the amount of DNA. The significance of the differences in histological scores and in thickness measurements were made by ANOVA test (P value < 0.05). RESULTS: In all animals of GB: the adhesive was attached to the mucosa; there was no pregnancy; no records of significant degree on inflammatory process; the patency test was negative and densitometry of DNA showed similar values to the both groups independently of observation periods. The layers thickness of GB-UT(1.118 +/- 0.117), GB-MT(0.447+/-0.247) and GB- @entity1 (0.853+/-0.097) were larger than the GS-UT(0.666+/-0.409), GS-MT(0.211+/-0.070) and GS- @entity1 (0.442+/-0.143). CONCLUSION: This approach offers a safe and feasible method of uterine tube obstruction.

title: Hysteroscopy and XXXX on experimental sterilization of @entity0 uterine tubes.

answer: @entity3


abstract: PURPOSE: To assess the sterilization effectiveness on uterine tube of @entity0 by the @entity2 adhesive. METHODS: Hysteroscopy tubal catheterization was performed randomly in 12 animals (24 uterine tubes) assigned to the sham group (GS) and 15 animals (30 uterine tubes) to the @entity3 (GB). The female @entity0 were observed during 30, 90 and 180 days and mated to fertile males. The no pregnant @entity0 were submitted to in vitro burst pressure test for patency by air insufflation (40 mmHg). The microscopic assessment was performed to parameters of damages in epithelium caused by the adhesive, the degree of inflammatory process, morphometry data values of tube diameter (UT) (cm), @entity4 ( @entity1 ) (mm). The mucosa cells densitometry (total optical density) was expressed by the amount of DNA. The significance of the differences in histological scores and in thickness measurements were made by ANOVA test (P value < 0.05). RESULTS: In all animals of GB: the adhesive was attached to the mucosa; there was no pregnancy; no records of significant degree on inflammatory process; the patency test was negative and densitometry of DNA showed similar values to the both groups independently of observation periods. The layers thickness of GB-UT(1.118 +/- 0.117), GB-MT(0.447+/-0.247) and GB- @entity1 (0.853+/-0.097) were larger than the GS-UT(0.666+/-0.409), GS-MT(0.211+/-0.070) and GS- @entity1 (0.442+/-0.143). CONCLUSION: This approach offers a safe and feasible method of uterine tube obstruction.

title: Hysteroscopy and @entity3 on experimental sterilization of XXXX uterine tubes.

answer: @entity0