abstract: BACKGROUND: Comorbidity of @entity2 and @entity5 can intensify both conditions, and when advanced age is added to the combination, the @entity0 will face a distinctive array of issues. This study evaluated the prevalence of @entity2 in elderly substance users as well as certain related factors. METHODS: This cross-sectional study was performed on 160 consenting elderly substance users 60 years and over who had been on @entity3 maintenance. The subjects were selected from rehabilitation centers affiliated with the Welfare Organization in Tehran through convenience sampling, and were assessed for current or lifetime axis-I @entity2 using the @entity6 questionnaire. RESULTS: In this study, 28.1% of substance abusers were diagnosed with at least one current @entity2 . @entity2 were more common in subjects whose @entity5 had started prior to the age of 35, or those who had a family history of substance use. Also, 34.4% had a lifetime history of at least one @entity2 , with a higher incidence among those simultaneously dependent on other substances in addition to opioids. @entity4 was the most @entity1 among the study subjects. CONCLUSION: Based on the findings of the present study, axis-I @entity2 are rather common among elderly substance users, and approximately a third of this population have a lifetime history of at least one such disorder. The type of abused substance can affect the incidence of @entity2 , and simultaneous use of non-opioids and other substances can increase their prevalence.

title: Psychiatric Comorbidities among Iranian Elderly XXXX on @entity3 Maintenance Treatment.

answer: @entity0


abstract: UNASSIGNED: Enteric illness associated with foodborne and @entity0 is thought to be common in some Canadian Indigenous communities. This study aimed to understand the lived experience of acute @entity2 (AGI), including symptoms and severity, perceived causes, and healthcare seeking behaviors of AGI in the small Inuit community of Rigolet, Canada. A concurrent mixed quantitative and qualitative methods design was used. Two cross-sectional retrospective surveys provided quantitative data to examine self-reported AGI symptoms and the distribution of potential risk factors in the community. Qualitative data from in-depth interviews with one-third of AGI cases were analyzed using a constant-comparative method to describe symptoms and severity, identify perceived risk factors, and explore health seeking behavior of AGI in Rigolet. Of the survey respondents reporting AGI, most reported symptoms of @entity1 without @entity4 , followed by @entity1 with @entity4 , and @entity4 without @entity1 . The most common secondary symptoms included stomach cramps and @entity5 , @entity3 , and extreme tiredness. Community members identified potential risk factors for AGI that reflect the epidemiology triad (host, agent, and environmental factors), including hygiene, retail food, tap water, boil water advisories, and personal stress. Risk aversion and healthcare seeking behaviors reflected the core constructs of the Health Belief Model (perceived susceptibility, severity, and benefits and barriers to action). Understanding community experience, perspectives, and beliefs related to AGI is useful for public health practitioners and health care providers. This information is important especially considering the relatively high estimated burden of AGI and the relatively low healthcare seeking behaviors in some Indigenous communities compared to national estimates. Moreover, the mixed-methods approach used to understand the burden of AGI could be extended to other health research in Indigenous contexts.

title: Lived experience of acute XXXX in Rigolet, Nunatsiavut: "Just suffer through it"

answer: @entity2


abstract: BACKGROUND: @entity6 remains the principal cause of @entity4 in @entity0 with @entity1 . @entity1 @entity2 display exacerbated @entity3 following @entity7 -reperfusion (MI/R) and are resistant to most therapeutic interventions. We have reported that @entity10 ( @entity10 ) therapy confers cardioprotection during MI/R in non- @entity1 @entity2 . Here we tested the hypothesis that @entity10 therapy would limit the extent of @entity5 following MI/R when administered at the time of reperfusion. METHODS AND RESULTS: @entity1 @entity2 (db/db, 12  weeks of age) were subjected to transient @entity7 for a period of 30  minutes followed by reperfusion up to 24  hours. @entity10 (0.05 to 1  mg/kg) or saline (vehicle) was administered into the left ventricular lumen at the time of reperfusion. @entity10 therapy significantly decreased @entity5 in the db/db @entity1 @entity2 , as evidenced by a reduction in @entity8 size and circulating troponin-I levels. The reduction in @entity5 was also associated with a reduction in oxidative stress and a decrease in cleaved caspase-3 expression. In an effort to evaluate the signaling mechanism responsible for the observed cardioprotection, additional groups of @entity2 were sacrificed during early reperfusion. Hearts were excised and processed for Western blot analysis. These studies revealed that @entity10 therapy activated the @entity9 arm of the Reperfusion Injury Salvage Kinase (RISK) pathway. CONCLUSION: These findings provide important information that myocardial @entity9 activation by @entity10 therapy following MI/R sets into motion events, which ultimately lead to cardioprotection in the setting of @entity1 .

title: Hydrogen sulfide provides cardioprotection against XXXX reperfusion @entity3 in the @entity1 state through the activation of the RISK pathway.

answer: @entity7


abstract: BACKGROUND: @entity6 remains the principal cause of @entity4 in @entity0 with @entity1 . @entity1 @entity2 display exacerbated @entity3 following @entity7 -reperfusion (MI/R) and are resistant to most therapeutic interventions. We have reported that @entity10 ( @entity10 ) therapy confers cardioprotection during MI/R in non- @entity1 @entity2 . Here we tested the hypothesis that @entity10 therapy would limit the extent of @entity5 following MI/R when administered at the time of reperfusion. METHODS AND RESULTS: @entity1 @entity2 (db/db, 12  weeks of age) were subjected to transient @entity7 for a period of 30  minutes followed by reperfusion up to 24  hours. @entity10 (0.05 to 1  mg/kg) or saline (vehicle) was administered into the left ventricular lumen at the time of reperfusion. @entity10 therapy significantly decreased @entity5 in the db/db @entity1 @entity2 , as evidenced by a reduction in @entity8 size and circulating troponin-I levels. The reduction in @entity5 was also associated with a reduction in oxidative stress and a decrease in cleaved caspase-3 expression. In an effort to evaluate the signaling mechanism responsible for the observed cardioprotection, additional groups of @entity2 were sacrificed during early reperfusion. Hearts were excised and processed for Western blot analysis. These studies revealed that @entity10 therapy activated the @entity9 arm of the Reperfusion Injury Salvage Kinase (RISK) pathway. CONCLUSION: These findings provide important information that myocardial @entity9 activation by @entity10 therapy following MI/R sets into motion events, which ultimately lead to cardioprotection in the setting of @entity1 .

title: Hydrogen sulfide provides cardioprotection against @entity7 reperfusion @entity3 in the XXXX state through the activation of the RISK pathway.

answer: @entity1


abstract: BACKGROUND: @entity6 remains the principal cause of @entity4 in @entity0 with @entity1 . @entity1 @entity2 display exacerbated @entity3 following @entity7 -reperfusion (MI/R) and are resistant to most therapeutic interventions. We have reported that @entity10 ( @entity10 ) therapy confers cardioprotection during MI/R in non- @entity1 @entity2 . Here we tested the hypothesis that @entity10 therapy would limit the extent of @entity5 following MI/R when administered at the time of reperfusion. METHODS AND RESULTS: @entity1 @entity2 (db/db, 12  weeks of age) were subjected to transient @entity7 for a period of 30  minutes followed by reperfusion up to 24  hours. @entity10 (0.05 to 1  mg/kg) or saline (vehicle) was administered into the left ventricular lumen at the time of reperfusion. @entity10 therapy significantly decreased @entity5 in the db/db @entity1 @entity2 , as evidenced by a reduction in @entity8 size and circulating troponin-I levels. The reduction in @entity5 was also associated with a reduction in oxidative stress and a decrease in cleaved caspase-3 expression. In an effort to evaluate the signaling mechanism responsible for the observed cardioprotection, additional groups of @entity2 were sacrificed during early reperfusion. Hearts were excised and processed for Western blot analysis. These studies revealed that @entity10 therapy activated the @entity9 arm of the Reperfusion Injury Salvage Kinase (RISK) pathway. CONCLUSION: These findings provide important information that myocardial @entity9 activation by @entity10 therapy following MI/R sets into motion events, which ultimately lead to cardioprotection in the setting of @entity1 .

title: Hydrogen sulfide provides cardioprotection against @entity7 reperfusion XXXX in the @entity1 state through the activation of the RISK pathway.

answer: @entity3


abstract: OBJECTIVE: To report 14 @entity0 with immune-mediated relapsing symptoms @entity6 ( @entity6 ) and to compare the clinical and immunologic features of the teenage and adult group with those of young @entity0 . METHODS: Prospective observational study of @entity0 diagnosed between June 2013 and February 2015. Immunologic techniques have been reported previously. RESULTS: Among the teenage and adult group (8 @entity0 , median age 40 years, range 13-69; 5 male), 3 had an acute symptom presentation suggesting a viral relapse, and 5 a presentation contiguous with @entity6 suggesting a recrudescence of previous deficits. Seven @entity0 developed severe @entity1 /behavioral symptoms disrupting all social interactions, and one refractory @entity2 . @entity5 occurred in one @entity0 . Five @entity0 had CSF antibodies against @entity3 receptor (NMDAR) and 3 against unknown neuronal cell surface proteins. In 5/6 @entity0 , the brain MRI showed new areas of contrast enhancement that decreased after immunotherapy and clinical improvement. Immunotherapy was useful in 7/7 @entity0 , sometimes with impressive recoveries, returning to their baseline @entity6 residual deficits. Compared with the 6 younger @entity0 (median age 13 months, range 6-20, all with NMDAR antibodies), the teenagers and adults were less likely to develop @entity4 (0/8 vs 6/6, p < 0.01) and decreased level of consciousness (2/8 vs 6/6, p < 0.01) and had longer delays in diagnosis and treatment (interval relapse/antibody testing 85 days, range 17-296, vs 4 days, range 0-33, p = 0.037). CONCLUSION: In teenagers and adults, the immune-mediated relapsing syndrome post- @entity6 is different from that known in young @entity0 as @entity6 and is underrecognized. Prompt diagnosis is important because immunotherapy can be highly effective.

title: Autoimmune XXXX of adults and teenagers.

answer: @entity6


abstract: Mallotus philippinensis is an important source of molecules with strong antioxidant activity widely used medicinal plant. Previous studies have highlighted their anticestodal, antibacterial, wound healing activities, and so forth. So, present investigation was designed to evaluate the total antioxidant activity and radical scavenging effect of 50% @entity3 fruit glandular hair extract ( @entity8 ) and its role on @entity0 Erythrocytes. @entity8 was tested for phytochemical test followed by its HPLC analysis. Standard antioxidant assays like DPPH, @entity10 , @entity7 , @entity1 radical, @entity2 , and lipid peroxidation assay were determined along with total phenolic and @entity4 content. Results showed that @entity8 contains the presence of various phytochemicals, with high total phenolic and @entity6 content. HPLC analysis showed the presence of @entity9 , a polyphenolic compound in a very rich quantity. @entity8 exhibits significant strong scavenging activity on DPPH and @entity10 assay. Reducing power showed dose dependent increase in concentration absorption compared to standard, @entity5 . @entity1 , @entity7 radical, lipid peroxidation, @entity2 assay showed a comparable scavenging activity compared to its standard. Our finding further provides evidence that Mallotus fruit extract is a potential natural source of antioxidants which have a protective role on @entity0 Erythrocytes exhibiting minimum hemolytic activity and this justified its uses in folklore medicines.

title: Antioxidant Capacity and Radical Scavenging Effect of Polyphenol Rich Mallotus philippenensis Fruit Extract on XXXX Erythrocytes: An In Vitro Study.

answer: @entity0


abstract: BACKGROUND: Optimizing liposomal vehicles for targeted delivery to the brain has important implications for the treatment of @entity3 . The promise of efficient, brain-specific delivery of chemotherapeutic compounds via liposomal vehicles has yet to be achieved in clinical practice. Intra-arterial injection of specially designed liposomes may facilitate efficient delivery to the brain and to @entity1 . OBJECTIVE: To test the hypothesis that cationic liposomes may be effectively delivered to both normal and @entity1 -bearing brain tissue utilizing a strategy of intra-arterial injection during transient @entity4 . METHODS: Cationic, anionic, and neutral liposomes were separately injected via the internal carotid artery of healthy @entity2 during transient @entity4 . @entity2 bearing C6 @entity1 were similarly injected with cationic liposomes. Liposomes were loaded with @entity5 whose concentrations can be measured by light absorbance and fluorescence methods. RESULTS: After intra-arterial injection, a robust uptake of cationic in comparison with anionic and neutral liposomes into brain parenchyma was observed by diffuse reflectance spectroscopy. Postmortem multispectral fluorescence imaging revealed that liposomal cationic charge was associated with more efficient delivery to the brain. Cationic liposomes were also readily observed within @entity1 tissue after intra-arterial injection. However, over time, cationic liposomes were retained longer and at higher concentrations in the surrounding, peritumoral brain than in the @entity0 core. CONCLUSION: This study demonstrates the feasibility of cationic liposome delivery to brain and @entity1 tissue after intra-arterial injection. Highly cationic liposomes directly delivered to the brain via an intracarotid route may represent an effective method for delivering antiglioma agents. ABBREVIATIONS: Chol, cholesterolDiD, DilC18(5)DMPC, dimyristoylphosphatidylcholineDOTAP, dioleoyl-trimethylammonium-propaneIA, intra-arterialMCA, middle cerebral arteryOP, optical pharmacokineticTCH, transient @entity4 .

title: Cerebral Hypoperfusion-Assisted Intra-arterial Deposition of Liposomes in Normal and Glioma-Bearing XXXX .

answer: @entity2


abstract: @entity2 is one of the leading causes of @entity0 worldwide, and the therapeutic application of @entity4 ( @entity4 ) is limited due to its nonspecificity, low bioavailability, and @entity3 . The present study is an attempt to improve the chemotherapeutic efficacy of @entity4 in @entity2 . Therefore, we have prepared @entity4 -loaded hyaluronic acid (HA)-conjugated @entity6 nanoparticles (SiNPs) to target to @entity2 cells. In this study, we have showed the specific binding and intracellular accumulation of targeted nanoparticles based on HA surface modifications in @entity2 cells. The particles had spherical shapes with sizes of approximately 130 nm. HA-conjugated nanoparticles showed a sustained release pattern for @entity4 and continuously released for 120 hours. We have further investigated the @entity1 potential of targeted and nontargeted nanoparticles in colo-205 @entity0 cells. IC50 value of @entity4 / @entity7 -conjugated @entity6 nanoparticles (HSNP) was 0.65   g/mL compared with ~2.8   g/mL for @entity4 /SNP after 24 hours of incubation. The result clearly showed that HA-conjugated NP was more effective in inducing apoptosis in @entity0 cells than nontargeted NP. The @entity4 /HSNP showed ~45% of cell apoptosis (early and late apoptosis stage) compared with only 20% for @entity4 / @entity6 nanoparticles (SNP)-treated group. The HA-conjugated nanoparticles provide the possibility of efficient drug transport into @entity0 that could effectively reduce the side effects in the normal tissues. @entity4 /HSNP was highly efficient in suppressing the @entity0 growth in xenograft @entity0 model. The proportion of Ki67 in @entity4 /HSNP-treated group was significantly lower than that of either free drug or nontargeted SiNPs. Altogether, we have showed that conjugation of HA to SiNPs could result in enhanced uptake of @entity4 through @entity5 -mediated endocytosis uptake and could result in significant antitumor efficacy. Thus, @entity4 /HSNP could be a promising drug delivery system for @entity2 therapy.

title: Hyaluronic acid-tagged @entity6 nanoparticles in XXXX therapy: therapeutic efficacy evaluation.

answer: @entity2


abstract: @entity2 is one of the leading causes of @entity0 worldwide, and the therapeutic application of @entity4 ( @entity4 ) is limited due to its nonspecificity, low bioavailability, and @entity3 . The present study is an attempt to improve the chemotherapeutic efficacy of @entity4 in @entity2 . Therefore, we have prepared @entity4 -loaded hyaluronic acid (HA)-conjugated @entity6 nanoparticles (SiNPs) to target to @entity2 cells. In this study, we have showed the specific binding and intracellular accumulation of targeted nanoparticles based on HA surface modifications in @entity2 cells. The particles had spherical shapes with sizes of approximately 130 nm. HA-conjugated nanoparticles showed a sustained release pattern for @entity4 and continuously released for 120 hours. We have further investigated the @entity1 potential of targeted and nontargeted nanoparticles in colo-205 @entity0 cells. IC50 value of @entity4 / @entity7 -conjugated @entity6 nanoparticles (HSNP) was 0.65   g/mL compared with ~2.8   g/mL for @entity4 /SNP after 24 hours of incubation. The result clearly showed that HA-conjugated NP was more effective in inducing apoptosis in @entity0 cells than nontargeted NP. The @entity4 /HSNP showed ~45% of cell apoptosis (early and late apoptosis stage) compared with only 20% for @entity4 / @entity6 nanoparticles (SNP)-treated group. The HA-conjugated nanoparticles provide the possibility of efficient drug transport into @entity0 that could effectively reduce the side effects in the normal tissues. @entity4 /HSNP was highly efficient in suppressing the @entity0 growth in xenograft @entity0 model. The proportion of Ki67 in @entity4 /HSNP-treated group was significantly lower than that of either free drug or nontargeted SiNPs. Altogether, we have showed that conjugation of HA to SiNPs could result in enhanced uptake of @entity4 through @entity5 -mediated endocytosis uptake and could result in significant antitumor efficacy. Thus, @entity4 /HSNP could be a promising drug delivery system for @entity2 therapy.

title: Hyaluronic acid-tagged XXXX nanoparticles in @entity2 therapy: therapeutic efficacy evaluation.

answer: @entity6


abstract: Individualized treatment regimens may reduce @entity0 burden with satisfactory @entity0 outcomes in neovascular age-related @entity2 . Intravitreal anti- @entity1 drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical trials. A PRN regimen requires monthly visits where the @entity0 is treated in the presence of signs of lesion activity. Therefore, an early detection of reactivation of the disease with immediate retreatment is crucial to prevent visual acuity loss. Several trials suggest that "treat and extend" and other proactive regimens provide a reasonable approach. The rationale of the proactive regimens is to perform treatment anticipating relapses or recurrences and therefore avoid drops in vision while individualizing @entity0 followup. Treat and extend study results in significant direct medical cost savings from fewer treatments and office visits compared to monthly treatment. Current data suggest that, for one year, PRN is less expensive, but treat and extend regimen would likely be less expensive for subsequent years. Once a @entity0 is not a candidate to continue with treatment, he/she should be sent to an outpatient unit with adequate resources to follow nAMD @entity0 in order to reduce the burden of specialized ophthalmologist services.

title: Individualized Therapy with Ranibizumab in Wet Age-Related XXXX .

answer: @entity2


abstract: Purpose. To determine the intraocular levels of growth factors and cytokines in @entity0 with various degrees of severity of @entity1 ( @entity1 ) using multiplex xMAP technology. Methods. A prospective cohort study of 61 eyes from 56 @entity0 who were divided into 3 groups based on the severity of @entity1 . @entity0 in group number 1 are those who presented @entity1 with no need of repeated surgical intervention; @entity0 in group number 2 had repeated @entity4 ; and @entity0 in group number 3 had @entity6 . The concentrations of proangiogenic, antiangiogenic, inflammatory, and neurotrophic factors were measured in intraocular fluid. The results were also compared with levels of factors measured in 50 eyes from 50 @entity0 prior to senile @entity3 surgery (control group). Results. @entity0 with @entity6 (the highest clinical severity group) had higher levels of @entity5 ( @entity5 ) (median1 37.19; median3 384.74; P = .00096), @entity7 ( @entity7 ) (median1 49.00; median3 414.40; P = .0017), and @entity2 ( @entity2 ) (median1 211.62; median3 352.82; P = .0454) compared with other @entity1 @entity0 . Conclusions. Results of our study imply that levels of @entity5 , @entity7 , and @entity2 correlate with the severity of @entity1 .

title: The Measurement of Intraocular Biomarkers in Various Stages of Proliferative XXXX Using Multiplex xMAP Technology.

answer: @entity1


abstract: BACKGROUND: We have previously demonstrated that @entity7 , a selective inhibitor of histone deacetylase (HDAC) 6, improves survival, and increases circulating monocyte count and bacterial clearance in a lethal model of @entity1 ( @entity1 ) in @entity0 . The aim of the present study was to characterize the effects of inhibition of @entity8 on the bone marrow cell population. METHODS: C57BL/6J @entity0 were subjected to @entity1 , and 1 h later given an intraperitoneal injection of either @entity7 (70 mg/kg) dissolved in @entity4 ( @entity4 ), or @entity4 alone (n=9/group). Sham-operated animals were treated in an identical fashion, without @entity1 . Forty-eight hours later, bone marrow cells were flushed out from the femurs and @entity2 . Erythrocytes were lysed, and a single-cell suspension was made for analysis. Cells were washed, blocked with anti-mouse @entity6 /32, stained with anti-mouse B220 PE-Cy7, CD3 APC-eFluor   780, @entity5 @entity3 , Gr-1 PerCP-Cy5.5 and F4/80 Antigen APC, and subjected to flow cytometry. Data was acquired on an LSRII Flow Cytometer (BD Biosciences) and analyzed with FlowJo (Flowjo, LLC). RESULTS: In comparison to the sham group, @entity1 animals showed decreased percentage of innate immune cells ( @entity5 +; 62.1  3.1 vs. 32.9  4.9%, p=0.0025) and macrophages ( @entity5 + F4/80+; 44.6  3.4 vs. 19.8  2.6%, p=0.0002), and increased percentage of T lymphocytes (CD3+; 1.1  0.2 vs. 3.3  0.4%, p=0.0082) in the bone marrow 48 h after @entity1 . Treatment with @entity7 restored the innate immune cells (32.9  4.9 vs. 54.0  4.1%, p=0.0112) and macrophages (19.8  2.6 vs. 47.1  4.6%, p=0.0001), and increased the percentage of neutrophils ( @entity5 + Gr-1+; 28.4  3.9 vs. 48.0  4.0%, p=0.0075). The percentages of B (B220+) and T lymphocytes were not significantly altered by @entity7 , compared to the vehicle-treated @entity1 animals. CONCLUSIONS: Selective inhibition of @entity8 in this lethal septic model restored the innate immune cell and macrophage populations, and increased the neutrophil composition in the bone marrow. These results may explain the previously reported beneficial effects of @entity7 treatment in a septic model. LEVELS OF EVIDENCE: not applicable (animal study).

title: Inhibition of XXXX restores innate immune cells in bone marrow in a lethal septic model.

answer: @entity8


abstract: BACKGROUND: External tibial torsion (ETT) is a common @entity1 in @entity0 with @entity2 ( @entity2 ). The current recommended treatment is @entity6 ( @entity6 ) to improve gait biomechanics. Satisfactory short-term results after @entity6 have been reported but long-term results have not been studied. The purpose of this study was to evaluate the long-term outcome following @entity6 to correct ETT in ambulatory @entity0 with @entity2 . METHODS: Following IRB approval, gait kinematics and passive range of motion measurements were retrospectively evaluated in @entity0 with @entity2 who underwent @entity6 due to ETT comparing preoperative (E0), short-term postoperative (E1; 1 to 3 y post), and long-term postoperative (E2; >5 y post) results. Limbs were categorized as corrected, undercorrected, or overcorrected at both @entity5 , by comparing mean tibial rotation (MTR) in gait to a group of typically developing @entity0 . Age at surgery, E0 MTR, E0 gait velocity, gross motor function classification system (GMFCS) score, and @entity7 were evaluated to determine their influence on long-term results. RESULTS: The study sample consisted of 43 legs (with @entity8 ) and 22 legs (with E0, E1, and E2). The mean age at surgery was 10.3  3.4 years (range, 6 to 19.2 y). In the group MTR trended toward improvement moving from -26  17 degrees (E0, external negative) to -16  16 degrees (E1) and relapsed to -23  17 degrees at the long term (P=0.071, E0/E1; P=0.589, E0/E2). Improvement was also seen in the @entity4 (P=0.074), mean @entity3 , and mean foot orientation (P<0.05, E0/E2). At the long-term evaluation, 16 legs (37%) were found to be in the kinematic corrected group, 25 legs (58%) in the kinematic undercorrected group, and 2 legs (5%) in the kinematic overcorrected group. There were no significant differences between the corrected and undercorrected groups of @entity0 with respect to age at surgery, GMFCS, E0 MTR, gait velocity, or @entity7 . CONCLUSIONS: Although internal @entity6 improves ETT in the short term, recurrence is frequent with an apparent developmental trend toward external rotation of the tibia. LEVELS OF EVIDENCE: Level IV-therapeutic study.

title: Long-term Outcome of Internal Tibial Derotation Osteotomies in @entity0 With XXXX .

answer: @entity2


abstract: BACKGROUND: External tibial torsion (ETT) is a common @entity1 in @entity0 with @entity2 ( @entity2 ). The current recommended treatment is @entity6 ( @entity6 ) to improve gait biomechanics. Satisfactory short-term results after @entity6 have been reported but long-term results have not been studied. The purpose of this study was to evaluate the long-term outcome following @entity6 to correct ETT in ambulatory @entity0 with @entity2 . METHODS: Following IRB approval, gait kinematics and passive range of motion measurements were retrospectively evaluated in @entity0 with @entity2 who underwent @entity6 due to ETT comparing preoperative (E0), short-term postoperative (E1; 1 to 3 y post), and long-term postoperative (E2; >5 y post) results. Limbs were categorized as corrected, undercorrected, or overcorrected at both @entity5 , by comparing mean tibial rotation (MTR) in gait to a group of typically developing @entity0 . Age at surgery, E0 MTR, E0 gait velocity, gross motor function classification system (GMFCS) score, and @entity7 were evaluated to determine their influence on long-term results. RESULTS: The study sample consisted of 43 legs (with @entity8 ) and 22 legs (with E0, E1, and E2). The mean age at surgery was 10.3  3.4 years (range, 6 to 19.2 y). In the group MTR trended toward improvement moving from -26  17 degrees (E0, external negative) to -16  16 degrees (E1) and relapsed to -23  17 degrees at the long term (P=0.071, E0/E1; P=0.589, E0/E2). Improvement was also seen in the @entity4 (P=0.074), mean @entity3 , and mean foot orientation (P<0.05, E0/E2). At the long-term evaluation, 16 legs (37%) were found to be in the kinematic corrected group, 25 legs (58%) in the kinematic undercorrected group, and 2 legs (5%) in the kinematic overcorrected group. There were no significant differences between the corrected and undercorrected groups of @entity0 with respect to age at surgery, GMFCS, E0 MTR, gait velocity, or @entity7 . CONCLUSIONS: Although internal @entity6 improves ETT in the short term, recurrence is frequent with an apparent developmental trend toward external rotation of the tibia. LEVELS OF EVIDENCE: Level IV-therapeutic study.

title: Long-term Outcome of Internal Tibial Derotation Osteotomies in XXXX With @entity2 .

answer: @entity0


abstract: OBJECTIVES: Thymosin alpha1 (Ta1) is considered a promising immunomodulatory drug. However, it is still unclear whether Ta1 should be recommended for the management of @entity1 . Here we conducted a systematic review and meta-analysis to assess the efficacy of Ta1 based immunomodulatory therapy on the clinical outcomes of septic @entity0 . METHODS: We searched for relevant clinical trials published before Dec. 12, 2014 through electronic databases. All articles about Ta1 based immunomodulatory therapy for @entity1 were included regardless of language. Two authors independently selected studies, extracted data and assessed the quality of each included study. We polled the data related to all-cause mortality with Review Manager 5.1. RESULTS: Twelve controlled trials were evaluated in all. Ta1 based immunomodulatory therapy had a significant trend toward lower all-cause mortality among @entity0 with @entity1 (pooled risk ratio 0.68, 95%CI 0.59-0.78, p<0.00001, 12 trials, n=1480). CONCLUSIONS: Ta1 based immunomodulatory therapy was associated with a lower mortality in septic @entity0 . Nevertheless, these findings should be interpreted cautiously because of the poor quality and small number of @entity0 of the included trials. More well-designed worldwide multicenter clinical trials are needed to provide a conclusive guideline for clinical practice.

title: Thymosin alpha1 based immunomodulatory therapy for XXXX : a systematic review and meta-analysis.

answer: @entity1


abstract: PURPOSE: There have been conflicting reports regarding the incidence of @entity2 in @entity0 receiving intensity modulated radiation therapy (IMRT) with an extended field covering the para-aortic (PA) lymph nodes for gynecologic @entity1 . We reviewed our experiences and rates of @entity2 in @entity0 treated with extended field IMRT. METHODS AND MATERIALS: @entity0 with either cervical or @entity4 who were treated with IMRT to the PA nodes for involved lymph nodes or for prophylactic intent between 2005 and 2013 were included. For prophylactic intent, the radiation dose to the PA nodes was 45 Gy in 25 fractions. For involved lymph nodes, a boost was delivered to the gross disease with a 0.7-cm expansion, with editing for critical structures. The entire duodenum was retrospectively contoured on all @entity0 from the gastric outlet to the jejunal transition. RESULTS: We identified 76 eligible @entity0 with @entity4 . The PA region was treated prophylactically in 46.1% (n = 35) and for involved PA lymph nodes in 53.9% (n = 41). The duodenum was contoured on all @entity0 with a median volume of 83.2 cm(3) (range, 21.2-174.9 cm(3)). The mean volume of duodenum receiving 55 Gy (V55) for those treated prophylactically and for involved PA nodes was 0 cm(3) and 0.8 cm(3) (range, 0-10.6 cm(3)), respectively (P = .014). Specifically, no @entity0 had a V55 >15 cm(3). The mean V40 was 28.3 cm(3) (range, 0-77.3 cm(3)) and 41.4 (range, 0-90.0 cm(3)), respectively (P = .016). The mean dose delivered to 2 cm(3) of the duodenum was 34.9 Gy (range, 0-52.3 Gy) and 50.1 Gy (range, 31.3 - 58.3 Gy), respectively. Grade 3 acute @entity3 was recorded in 3.9% (n = 3) of @entity0 . CONCLUSIONS: In our experience, the treatment of PA lymph nodes using an IMRT technique is associated with a low @entity2 profile and there has been no high-grade late @entity2 .

title: Extended field intensity modulated radiation therapy for gynecologic @entity1 : Is the risk of XXXX high?

answer: @entity2


abstract: PURPOSE: There have been conflicting reports regarding the incidence of @entity2 in @entity0 receiving intensity modulated radiation therapy (IMRT) with an extended field covering the para-aortic (PA) lymph nodes for gynecologic @entity1 . We reviewed our experiences and rates of @entity2 in @entity0 treated with extended field IMRT. METHODS AND MATERIALS: @entity0 with either cervical or @entity4 who were treated with IMRT to the PA nodes for involved lymph nodes or for prophylactic intent between 2005 and 2013 were included. For prophylactic intent, the radiation dose to the PA nodes was 45 Gy in 25 fractions. For involved lymph nodes, a boost was delivered to the gross disease with a 0.7-cm expansion, with editing for critical structures. The entire duodenum was retrospectively contoured on all @entity0 from the gastric outlet to the jejunal transition. RESULTS: We identified 76 eligible @entity0 with @entity4 . The PA region was treated prophylactically in 46.1% (n = 35) and for involved PA lymph nodes in 53.9% (n = 41). The duodenum was contoured on all @entity0 with a median volume of 83.2 cm(3) (range, 21.2-174.9 cm(3)). The mean volume of duodenum receiving 55 Gy (V55) for those treated prophylactically and for involved PA nodes was 0 cm(3) and 0.8 cm(3) (range, 0-10.6 cm(3)), respectively (P = .014). Specifically, no @entity0 had a V55 >15 cm(3). The mean V40 was 28.3 cm(3) (range, 0-77.3 cm(3)) and 41.4 (range, 0-90.0 cm(3)), respectively (P = .016). The mean dose delivered to 2 cm(3) of the duodenum was 34.9 Gy (range, 0-52.3 Gy) and 50.1 Gy (range, 31.3 - 58.3 Gy), respectively. Grade 3 acute @entity3 was recorded in 3.9% (n = 3) of @entity0 . CONCLUSIONS: In our experience, the treatment of PA lymph nodes using an IMRT technique is associated with a low @entity2 profile and there has been no high-grade late @entity2 .

title: Extended field intensity modulated radiation therapy for gynecologic XXXX : Is the risk of @entity2 high?

answer: @entity1


abstract: OBJECTIVES: Nonspecific clinical symptoms frequently lead to suspicion of @entity3 in critically ill @entity0 . Clinicians send bacterial cultures for suspected @entity1 and begin an empiric course of antibiotics while microbiology results are pending. We investigated whether the biomarker @entity2 could be useful to predict confirmed @entity3 in critically ill @entity0 in the PICU, before culture results are available. DESIGN: Prospective, blinded single-center study. SETTING: Tertiary PICU and cardiothoracic ICU. @entity0 : There were one hundred forty-four @entity0 with suspected @entity3 that had bacterial cultures sent by clinicians. INTERVENTIONS: @entity2 samples were obtained at three time intervals: as close to the time of the initial culture as possible (up to 12 hr after) and 24 and 72 hours after the initial culture. @entity0 were stratified into clinical outcome groups based on microbiology results and clinical symptoms using Centers for Disease Control and Prevention criteria. These assignments were blinded to @entity2 levels. Primary outcome was the presence of culture-proven @entity3 . MEASUREMENTS AND MAIN RESULTS: There was a statistically significant difference in initial and subsequent median @entity2 values between @entity0 with confirmed @entity3 and @entity0 with low suspicion of @entity3 (p < 0.02). However, there was extremely high variability in @entity2 values among all groups. @entity2 had only a fair ability to predict @entity3 , with area under the curve of receiver operating characteristic plots ranging between 0.63 and 0.71. When using serial @entity2 values to predict @entity3 were near 1 and negative likelihood ratios were between 0.3 and 0.4. CONCLUSIONS: @entity2 levels were higher in @entity0 with documented confirmed @entity3 as compared with those with low suspicion of @entity1 . However, neither single nor serial @entity2 measurements were able to predict the presence or absence of confirmed @entity3 with enough certainty to be clinically useful as to recommend initiating or withholding antibiotics.

title: XXXX to Detect Suspected Bacterial Infections in the PICU.

answer: @entity2


abstract: PURPOSE: To analyze the 10-year results of corneal collagen crosslinking (CXL) for @entity2 . SETTING: Department of Ophthalmology, University Hospital, Dresden, Germany. DESIGN: Retrospective interventional case series. METHODS: The study included eyes treated for progressive @entity2 from 2000 to 2004. Corneal collagen crosslinking was performed by applying @entity1 and ultraviolet-A. The corrected distance visual acuity (CDVA), corneal topography, and endothelial cell count (ECC) were recorded preoperatively and 10  years postoperatively. RESULTS: The study enrolled 24 @entity0 (34 eyes). The mean age of the 18 @entity0 and 6 @entity0 was 28.4 years      7.3 (SD) and the mean follow-up, 131.9      20.1  months. The mean apical keratometry (K) value was 61.5 diopters (D) preoperatively and 55.3 D 10  years postoperatively; the decrease was statistically significant (P<.001). The mean values for maximum K (53.2 D and 49.56 D, respectively) and minimum K (47.5 D and 45.5 D, respectively) were also significantly lower (P<.001). The preoperative and postoperative CDVA were statistically significantly different (P=.002). The mean CDVA improved by 0.14 logMAR over preoperatively; the change was statistically significant (P=.002). The ECC was unchanged. CONCLUSIONS: Corneal CXL was effective in treating progressive @entity2 , achieving long-term stabilization of the condition. It was easy to perform, had a good safety profile, and reduced the need for corneal transplantation. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Corneal collagen crosslinking with  @entity1 and ultraviolet-A light in  progressive XXXX : Ten-year results.

answer: @entity2


abstract: PURPOSE: To analyze the 10-year results of corneal collagen crosslinking (CXL) for @entity2 . SETTING: Department of Ophthalmology, University Hospital, Dresden, Germany. DESIGN: Retrospective interventional case series. METHODS: The study included eyes treated for progressive @entity2 from 2000 to 2004. Corneal collagen crosslinking was performed by applying @entity1 and ultraviolet-A. The corrected distance visual acuity (CDVA), corneal topography, and endothelial cell count (ECC) were recorded preoperatively and 10  years postoperatively. RESULTS: The study enrolled 24 @entity0 (34 eyes). The mean age of the 18 @entity0 and 6 @entity0 was 28.4 years      7.3 (SD) and the mean follow-up, 131.9      20.1  months. The mean apical keratometry (K) value was 61.5 diopters (D) preoperatively and 55.3 D 10  years postoperatively; the decrease was statistically significant (P<.001). The mean values for maximum K (53.2 D and 49.56 D, respectively) and minimum K (47.5 D and 45.5 D, respectively) were also significantly lower (P<.001). The preoperative and postoperative CDVA were statistically significantly different (P=.002). The mean CDVA improved by 0.14 logMAR over preoperatively; the change was statistically significant (P=.002). The ECC was unchanged. CONCLUSIONS: Corneal CXL was effective in treating progressive @entity2 , achieving long-term stabilization of the condition. It was easy to perform, had a good safety profile, and reduced the need for corneal transplantation. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Corneal collagen crosslinking with  XXXX and ultraviolet-A light in  progressive @entity2 : Ten-year results.

answer: @entity1


abstract: PURPOSE: To compare by age the safety, efficacy, and @entity0 satisfaction after simultaneous laser in situ keratomileusis (LASIK) and small-aperture corneal inlay implantation (Kamra) for hyperopic @entity2 . SETTING: Shinagawa LASIK Center, Tokyo, Japan. DESIGN: Retrospective comparative cohort study. METHODS: Simultaneous LASIK and small-aperture corneal inlay implantation were performed in the nondominant eye of hyperopic presbyopic @entity0 with @entity1 . @entity0 were divided into groups by age as follows: Group 1 (40 to 49  years), Group 2 (50 to 59  years), and Group 3 (60 to 65  years). The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, uncorrected near visual acuity (UNVA), and @entity0 questionnaire results were compared. RESULTS: The study evaluated 277 eyes of 277 @entity0 . All groups achieved a mean UDVA of 20/20, with Group 1, Group 2, and Group 3 gaining 1 line, 2 lines, and 3 lines, respectively. The mean UNVA was J2 with 4 lines gained in Group 1 and J3 with 5 lines gained in Group 2 and Group 3. The mean CDVA and corrected near visual acuity remained the same as at baseline. CONCLUSIONS: Simultaneous LASIK and small-aperture corneal inlay implantation for hyperopic @entity2 was a safe and effective treatment option. Although the outcomes were comparable between groups, Group 3 had the largest gain in UDVA and UNVA and the highest @entity0 satisfaction, despite having the lowest reduction in dependence on reading glasses. Taking age into account might help achieve optimum postoperative outcomes and improved @entity0 satisfaction. FINANCIAL DISCLOSURE: Dr. Tomita is a consultant to Ziemer Ophthalmic Systems AG, Acufocus, Inc., and Schwind eye-tech-solutions GmbH and Co. KG. Dr. Waring is a consultant to Acufocus, Inc.

title: One-year results of simultaneous laser in situ keratomileusis and small-aperture corneal inlay implantation for hyperopic XXXX : Comparison by age.

answer: @entity2


abstract: The hypothesis that reflux of upper intestinal content, particularly of @entity5 (BA), is responsible for a unique postgastrectomy syndrome, @entity4 , was tested on 28 occasions in 21 postoperative @entity0 (14 symptomatic @entity0 , 7 controls). Parameters evaluated: recumbent (rec.), upright, p.c. intragastric pH, {BA}, net BA reflux per hour, specific BA fractions, fasting and p.c. @entity7 , maximal acid output (MAO), gastric emptying of solids by delta-scintigraphy), and the severity of nonstomal histologic @entity4 , the " @entity4 score," graded 0-15 by an independent senior pathologist. For the entire group, @entity4 severity correlated positively with intragastric {BA} and net BA reflux per hour, both in recumbency and p.c. Five symptomatic @entity0 demonstrated rec. and p.c. {BA} and net BA reflux per hour greater than two standard deviations from comparable mean values in control @entity0 . They differed significantly from the remaining symptomatic @entity0 as follows: increased intragastric {BA} and net BA reflux per hour, increased intragastric pH and decreased MAO. They also demonstrated a more severe grade of @entity4 . @entity6 was present in their reflux content significantly more often. Bilious vomiting was also more frequent. No other differences could be identified, either objectively or clinically, between the symptomatic groups. Four @entity0 with excessive reflux underwent Roux-en-Y revision and restudy 6-22 months later. BA reflux was completely abolished, histologic @entity4 improved, hematocrit rose, MAO increased, and gastric emptying slowed. Burning @entity1 , and symptoms of esophageal reflux were eliminated. Vomiting and @entity3 were improved. @entity2 was unchanged. The objective criteria outlined can identify symptomatic postgastrectomy @entity0 with a greater than normal reflux and @entity4 . Clinical criteria alone cannot. Revisional surgery in these @entity0 eliminates reflux, improves @entity4 , and produces symptomatic improvement. The hypothesis under consideration is strengthened but not proven.

title: XXXX . An objective assessment of its diagnosis and treatment.

answer: @entity4


abstract: Mixed @entity2 refers to a @entity0 that comprises 2 or more distinct histotypes. We studied 18 mixed-type @entity2 -11 mixed serous and low-grade @entity3 (SC/EC), 5 mixed clear cell and low-grade ECs (CCC/EC), and 2 mixed CCC and SCs (CCC/SC), using targeted next-generation sequencing and immunohistochemistry to compare the molecular profiles of the different histotypes present in each case. In 16 of 18 cases there was molecular evidence that both components shared a clonal origin. Eight cases (6 EC/SC, 1 EC/CCC, and 1 SC/CCC) showed an SC molecular profile that was the same in both components. Five cases (3 CCC/EC and 2 SC/EC) showed a shared endometrioid molecular profile and identical mismatch-repair @entity1 in both components. A single SC/EC case harbored the same POLE exonuclease domain mutation in both components. One SC/CCC and 1 EC/CCC case showed both shared and unique molecular features in the 2 histotype components, suggesting early molecular divergence from a common clonal origin. In 2 cases, there were no shared molecular features, and these appear to be biologically unrelated @entity0 . Overall, these results show that the different histologic components in mixed @entity2 typically share the same molecular aberrations. Mixed @entity2 most commonly occur through morphologic mimicry, whereby @entity0 with serous-type molecular profile show morphologic features of EC or CCC, or through underlying deficiency in DNA nucleotide repair, with resulting rapid accrual of mutations and intratumoral phenotypic heterogeneity. Less commonly, mixed @entity2 are the result of early molecular divergence from a common progenitor clone or are synchronous biologically unrelated @entity0 ( @entity0 ).

title: Molecular Analysis of Mixed XXXX Shows Clonality in Most Cases.

answer: @entity2


abstract: BACKGROUND: The use of functional appliances for the correction of retrognathic mandible is very common in orthodontics. Similar appliances known as oral appliances are also frequently used in adults for the treatment of mild to moderate @entity1 ( @entity1 ). Many studies have reported improvement of pharyngeal airway passage (PAP) dimensions following functional appliance therapy in @entity0 and oral appliance therapy in adults. There is only one study in the literature that discussed the effect of oral appliance therapy on @entity3 ( @entity3 ) among subjects with @entity1 . The effect of functional appliance therapy on @entity3 has never been investigated. Thus the present study was conducted to evaluate the effects of twin-block appliance on pharyngeal airway passage (PAP) dimensions and @entity3 ( @entity3 ) in class II @entity2 subjects with retrognathic mandibles. METHODS: Thirty-eight class II @entity2 subjects in the age range of 8 to 14 years with mandibular retrusion were divided into a treatment (n   =   20) and control (n   =   18) group. Mandibular retrusion in the treatment group subjects was corrected by twin-block appliance. The effect of twin-block appliance on PAP and @entity3 dimensions were evaluated from lateral cephalograms recorded prior-to and after 6 months of appliance therapy in the treatment group subjects and the changes were compared with the changes in the control group subjects. Student's t-test was used for statistical analysis; P-value of 0.05 was considered a statistically significant level. RESULTS: The depth of the oropharynx was increased significantly in the treatment group subjects (P   <   0.001) as compared to the control group subjects (P   <   0.05). The depth of the hypopharynx increased significantly in treatment group subjects (P   <   0.01). The @entity3 at the level of the nasopharynx, oropharynx, and hypopharynx were maintained in the treatment group subjects; whereas in control group subjects, the @entity3 was further reduced although the changes were not statistically significant. CONCLUSIONS: Correction of mandibular retrusion by twin-block appliance in class II @entity2 subjects increased the PAP dimensions and maintained the pre-treatment thickness of posterior pharyngeal wall.

title: Effects of twin-block appliance on the anatomy of pharyngeal airway passage (PAP) in class II XXXX subjects.

answer: @entity2


abstract: BACKGROUND: Concern about @entity5 ( @entity5 ) has governed recent thinking about the role of radiation therapy in the treatment of @entity4 involving the anterior optic pathways. Despite this concern, during the last few years, the use of radiosurgery for such lesions has increased steadily. OBJECTIVE: To define both the @entity1 control rate and the risk of @entity5 over a long-term follow-up period in a large cohort of @entity0 treated with multisession radiosurgery. METHODS: The local control and visual outcome of 143 @entity0 who underwent multisession radiosurgery ( @entity6 ) were evaluated. Neurological outcome was also analyzed. The data for the present study were obtained from a prospectively maintained database. RESULTS: The mean follow-up was 44 months (range, 12-113 months). All @entity0 underwent @entity6 . The median prescription dose was 25 Gy delivered in 3 to 5 fractions. The prescription isodose, which typically encompassed at least 95% of the @entity1 , ranged from 65% to 86% (median, 80%). The mean @entity1 volume was 11.0 cm (range, 0.1-126.3 cm; median, 8 cm). The progression-free survival at 3, 5, and 8 years was 100%, 93%, and 90%, respectively. Compared with baseline, visual function improved in 36% of @entity0 , whereas 7.4% experienced a @entity3 (5.1% excluding the @entity0 with @entity2 ). CONCLUSION: Good local control rate and a low risk of @entity5 indicate that @entity6 is a safe and effective treatment option in cases of large @entity4 . ABBREVIATIONS: AOP, anterior optic pathwayAVP, anterior visual pathwaymRS, multisession radiosurgeryPD, progressive diseaseRION, radiation-induced optic neuropathysRS, stereotactic radiosurgery.

title: Multisession Radiosurgery for Sellar and Parasellar XXXX : Long-term @entity1 Growth Control and Visual Outcome.

answer: @entity4


abstract: BACKGROUND: Concern about @entity5 ( @entity5 ) has governed recent thinking about the role of radiation therapy in the treatment of @entity4 involving the anterior optic pathways. Despite this concern, during the last few years, the use of radiosurgery for such lesions has increased steadily. OBJECTIVE: To define both the @entity1 control rate and the risk of @entity5 over a long-term follow-up period in a large cohort of @entity0 treated with multisession radiosurgery. METHODS: The local control and visual outcome of 143 @entity0 who underwent multisession radiosurgery ( @entity6 ) were evaluated. Neurological outcome was also analyzed. The data for the present study were obtained from a prospectively maintained database. RESULTS: The mean follow-up was 44 months (range, 12-113 months). All @entity0 underwent @entity6 . The median prescription dose was 25 Gy delivered in 3 to 5 fractions. The prescription isodose, which typically encompassed at least 95% of the @entity1 , ranged from 65% to 86% (median, 80%). The mean @entity1 volume was 11.0 cm (range, 0.1-126.3 cm; median, 8 cm). The progression-free survival at 3, 5, and 8 years was 100%, 93%, and 90%, respectively. Compared with baseline, visual function improved in 36% of @entity0 , whereas 7.4% experienced a @entity3 (5.1% excluding the @entity0 with @entity2 ). CONCLUSION: Good local control rate and a low risk of @entity5 indicate that @entity6 is a safe and effective treatment option in cases of large @entity4 . ABBREVIATIONS: AOP, anterior optic pathwayAVP, anterior visual pathwaymRS, multisession radiosurgeryPD, progressive diseaseRION, radiation-induced optic neuropathysRS, stereotactic radiosurgery.

title: Multisession Radiosurgery for Sellar and Parasellar @entity4 : Long-term XXXX Growth Control and Visual Outcome.

answer: @entity1


abstract: Radioactive @entity3 125 is a low-energy gamma isotope with physical characteristics suitable for irradiation of @entity0 . Metal ophthalmic applicators have been designed to shield vital ocular structures while allowing irradiation of the @entity0 . We compared the radiation effects of @entity3 125 and @entity4 60. The Greene @entity2 was transplanted into the suprachoroidal space of @entity1 . The @entity0 then grew as an intraocular mass, was irradiated, and was followed up for two months before enucleation. Histopathologic examination defined the extent of the radiation damage to the @entity0 and other ocular structures from the @entity3 125 and from the @entity4 60. The eye irradiated with @entity3 125 suffered minimal radiation damage, whereas the @entity0 was sterilized. The eye irradiated with @entity4 60 showed substantial radiation damage, and the @entity2 was incompletely treated. Our results support the use of @entity3 125 in treating @entity0 . More research is needed as to optimum total dose and dose rate.

title: Irradiation of @entity2 with XXXX 125 ophthalmic plaque.

answer: @entity3


abstract: Radioactive @entity3 125 is a low-energy gamma isotope with physical characteristics suitable for irradiation of @entity0 . Metal ophthalmic applicators have been designed to shield vital ocular structures while allowing irradiation of the @entity0 . We compared the radiation effects of @entity3 125 and @entity4 60. The Greene @entity2 was transplanted into the suprachoroidal space of @entity1 . The @entity0 then grew as an intraocular mass, was irradiated, and was followed up for two months before enucleation. Histopathologic examination defined the extent of the radiation damage to the @entity0 and other ocular structures from the @entity3 125 and from the @entity4 60. The eye irradiated with @entity3 125 suffered minimal radiation damage, whereas the @entity0 was sterilized. The eye irradiated with @entity4 60 showed substantial radiation damage, and the @entity2 was incompletely treated. Our results support the use of @entity3 125 in treating @entity0 . More research is needed as to optimum total dose and dose rate.

title: Irradiation of XXXX with @entity3 125 ophthalmic plaque.

answer: @entity2


abstract: OBJECTIVE: A timely initiation of treatment is crucial to better control @entity1 ( @entity1 ). The aim of this study is to describe treatment delay among migrant @entity0 with @entity1 and to identify factors associated with treatment delay, so as to provide evidence for strategy development and improvement of @entity1 control among migrants in China. DESIGN: A cross-sectional study was conducted in Shandong province of China. A total of 314 confirmed smear positive migrant @entity0 with @entity2 were included. Univariate logistic regression was used to analyse the association of variables with treatment delay among migrant @entity0 with @entity1 . A multilogistic regression model was developed to further assess the effect of variables on treatment delay. RESULTS: Of 314 migrant @entity0 with @entity1 , 65.6% experienced treatment delay (>1   day). Household income level, diagnosis symptom severity, understanding of whether @entity1 is curable or not and knowledge about the free @entity1 treatment policy are factors significantly associated with treatment delay. CONCLUSIONS: Economic status and knowledge about @entity1 are key barriers to accessing @entity1 treatment. An integrated policy of carrying out @entity1 -related health education and publicising the free @entity1 treatment policy among migrants is needed. Health insurance schemes for migrants should be modified to make them transferrable and pro-poor.

title: XXXX among migrants in Shandong, China: factors associated with treatment delay.

answer: @entity2


abstract: AIM: To evaluate @entity2 ( @entity2 )-related @entity1 in New Zealand @entity0 . METHODS: 22-year retrospective review of medical records of @entity0 with moderate to severe @entity1 registered with the Blind and @entity3 Education Network New Zealand. The cohort was divided into two periods (1991-2004; 2005-2012) for analysis. RESULTS: 232 @entity0 with @entity2 were treated in the study period (109 in period 1, 123 in @entity4 ). 36 @entity0 , 63.9% of whom were of male sex, were identified with subsequent significant @entity1 (27 in period 1, 9 in @entity4 ). The incidence of new cases of @entity1 from @entity2 declined from 271.6 @entity0 /100   000 live very preterm births per annum (period 1) to 146.1 per annum ( @entity4 ). Mean gestational age and mean birth weight were comparable between the two study periods. 75% of @entity0 with @entity1 from @entity2 received treatment for their condition (period 1, 74.1%; @entity4 , 77.8%) and modalities used changed significantly over time. The modal visual outcome overall was Snellen visual acuity <6/18-6/60 (55.6%) (period 1, 51.9%; @entity4 , 66.7%). The proportion of @entity0 with no light perception bilaterally decreased over time (period 1, 3.7%; @entity4 , 0%). CONCLUSIONS: There has been a reduction in the incidence of @entity0 with significant @entity1 from @entity2 over time in New Zealand, likely due to progress in clinical management of @entity2 . Our study suggests the current @entity2 screening criteria of <31   weeks' gestation or <1250   g are of sufficient breadth.

title: XXXX due to @entity2 ( @entity2 ) in New Zealand: a 22-year review.

answer: @entity1


abstract: AIM: To evaluate @entity2 ( @entity2 )-related @entity1 in New Zealand @entity0 . METHODS: 22-year retrospective review of medical records of @entity0 with moderate to severe @entity1 registered with the Blind and @entity3 Education Network New Zealand. The cohort was divided into two periods (1991-2004; 2005-2012) for analysis. RESULTS: 232 @entity0 with @entity2 were treated in the study period (109 in period 1, 123 in @entity4 ). 36 @entity0 , 63.9% of whom were of male sex, were identified with subsequent significant @entity1 (27 in period 1, 9 in @entity4 ). The incidence of new cases of @entity1 from @entity2 declined from 271.6 @entity0 /100   000 live very preterm births per annum (period 1) to 146.1 per annum ( @entity4 ). Mean gestational age and mean birth weight were comparable between the two study periods. 75% of @entity0 with @entity1 from @entity2 received treatment for their condition (period 1, 74.1%; @entity4 , 77.8%) and modalities used changed significantly over time. The modal visual outcome overall was Snellen visual acuity <6/18-6/60 (55.6%) (period 1, 51.9%; @entity4 , 66.7%). The proportion of @entity0 with no light perception bilaterally decreased over time (period 1, 3.7%; @entity4 , 0%). CONCLUSIONS: There has been a reduction in the incidence of @entity0 with significant @entity1 from @entity2 over time in New Zealand, likely due to progress in clinical management of @entity2 . Our study suggests the current @entity2 screening criteria of <31   weeks' gestation or <1250   g are of sufficient breadth.

title: @entity1 due to XXXX ( @entity2 ) in New Zealand: a 22-year review.

answer: @entity2


abstract: AIM: To evaluate @entity2 ( @entity2 )-related @entity1 in New Zealand @entity0 . METHODS: 22-year retrospective review of medical records of @entity0 with moderate to severe @entity1 registered with the Blind and @entity3 Education Network New Zealand. The cohort was divided into two periods (1991-2004; 2005-2012) for analysis. RESULTS: 232 @entity0 with @entity2 were treated in the study period (109 in period 1, 123 in @entity4 ). 36 @entity0 , 63.9% of whom were of male sex, were identified with subsequent significant @entity1 (27 in period 1, 9 in @entity4 ). The incidence of new cases of @entity1 from @entity2 declined from 271.6 @entity0 /100   000 live very preterm births per annum (period 1) to 146.1 per annum ( @entity4 ). Mean gestational age and mean birth weight were comparable between the two study periods. 75% of @entity0 with @entity1 from @entity2 received treatment for their condition (period 1, 74.1%; @entity4 , 77.8%) and modalities used changed significantly over time. The modal visual outcome overall was Snellen visual acuity <6/18-6/60 (55.6%) (period 1, 51.9%; @entity4 , 66.7%). The proportion of @entity0 with no light perception bilaterally decreased over time (period 1, 3.7%; @entity4 , 0%). CONCLUSIONS: There has been a reduction in the incidence of @entity0 with significant @entity1 from @entity2 over time in New Zealand, likely due to progress in clinical management of @entity2 . Our study suggests the current @entity2 screening criteria of <31   weeks' gestation or <1250   g are of sufficient breadth.

title: @entity1 due to @entity2 ( XXXX ) in New Zealand: a 22-year review.

answer: @entity2


abstract: @entity2 ( @entity2 ) affects over 3 000 @entity0 in Poland annually The efficacy of the therapy remains relatively low due to challenges of systematic improvement in the early detection @entity2 rates. International comparisons indicate a positive correlation between health expenditures and 5-year survival rates of @entity1 @entity0 . To the best of our knowledge, our study has been the first to present a correlation between the 5-year survival rates (SRs) and the cost of @entity2 therapy in particular regions of Poland. MATERIAL AND METHODS: The study was based on the National Health Fund (NHF) data, available in the Disease Treatment Registry The analysis included approximately 13,000 @entity2 @entity0 who started their treatment between 2005 and 2008 to allow for the evaluation of long-term therapy results. The 5-year survival rates were analyzed in relation to average @entity3 in various regions of Poland, distinguishing the population of @entity0 aged 45-64 years. RESULTS: The 5-year survival rate in the cohorts diagnosed in 2005 and 2008 changed marginally from 42% to 43%, maintaining relatively large differences between the regions (from 35% to 53% in @entity0 diagnosed in 2008). The @entity3 in particular regions differed significantly: mean cost for the entire treatment cycle ranged from 31.600 PLN do 58.000 PLNperperson among @entity0 diagnosed in 2008. No significant correlation between the survival and the cost was found. CONCLUSIONS: SRs of @entity2 @entity0 in particular regions of Poland are not correlated with average treatment cost. Thus, the differences in SRs between various regions of Poland have their source in other factors, e.g., clinical stage at diagnosis, or prevailing treatment patterns in the given region. Further studies may decrease regional discrepancies in @entity0 care and SRs in @entity2 subjects.

title: [Efficacy and costs of XXXX therapy in Poland--regional approach].

answer: @entity2


abstract: BACKGROUND: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. OBJECTIVE: The objective was to explore whether the ND has an impact on gene expression in abdominal @entity4 ( @entity4 ) and whether changes in gene expression are associated with clinical and biochemical effects. DESIGN: Obese adults with features of the @entity3 underwent an 18- to 24-wk randomized intervention study comparing the ND with the @entity1 ( @entity1 ) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included @entity0 from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of   4 kg, highly sensitive C-reactive protein concentration <10 mg/L at the beginning and the end of the intervention, and baseline body mass index (in kg/m(2)) <38. @entity4 biopsy specimens were obtained before and after the intervention and subjected to global transcriptome analysis with Gene 1.1 ST Arrays (Affymetrix). RESULTS: Altogether, 128 genes were differentially expressed in @entity4 between the ND and @entity1 (nominal P < 0.01; false discovery rate, 25%). These genes were overrepresented in pathways related to immune response (adjusted P = 0.0076), resulting mainly from slightly decreased expression in the ND and increased expression in the @entity1 . Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., @entity6 , @entity9 ), adaptive immune response ( @entity5 , @entity7 ), and reactive @entity2 species ( @entity8 ). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor kB. CONCLUSION: A healthy Nordic diet reduces inflammatory gene expression in @entity4 compared with a @entity1 independently of body weight change in individuals with features of the @entity3 . The study was registered at clinicaltrials.gov as NCT00992641.

title: Healthy Nordic diet downregulates the expression of genes involved in inflammation in XXXX in individuals with features of the @entity3 .

answer: @entity4


abstract: BACKGROUND: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets. OBJECTIVE: The objective was to explore whether the ND has an impact on gene expression in abdominal @entity4 ( @entity4 ) and whether changes in gene expression are associated with clinical and biochemical effects. DESIGN: Obese adults with features of the @entity3 underwent an 18- to 24-wk randomized intervention study comparing the ND with the @entity1 ( @entity1 ) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included @entity0 from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of   4 kg, highly sensitive C-reactive protein concentration <10 mg/L at the beginning and the end of the intervention, and baseline body mass index (in kg/m(2)) <38. @entity4 biopsy specimens were obtained before and after the intervention and subjected to global transcriptome analysis with Gene 1.1 ST Arrays (Affymetrix). RESULTS: Altogether, 128 genes were differentially expressed in @entity4 between the ND and @entity1 (nominal P < 0.01; false discovery rate, 25%). These genes were overrepresented in pathways related to immune response (adjusted P = 0.0076), resulting mainly from slightly decreased expression in the ND and increased expression in the @entity1 . Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., @entity6 , @entity9 ), adaptive immune response ( @entity5 , @entity7 ), and reactive @entity2 species ( @entity8 ). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor kB. CONCLUSION: A healthy Nordic diet reduces inflammatory gene expression in @entity4 compared with a @entity1 independently of body weight change in individuals with features of the @entity3 . The study was registered at clinicaltrials.gov as NCT00992641.

title: Healthy Nordic diet downregulates the expression of genes involved in inflammation in @entity4 in individuals with features of the XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity0 studies demonstrated that allergen-specific immunotherapy (IT) represents an effective treatment for @entity3 . IT involves repeated administration of the sensitizing allergen, indicating a crucial contribution of T cells to its medicinal benefit. However, the underlying mechanisms of IT, especially in a @entity4 , are far from being definitive. In the current study, we sought to elucidate the suppressive mechanisms of IT in a @entity1 model of @entity3 . OVA-sensitized @entity1 were challenged with OVA or PBS for 4 wk. After development of @entity2 , @entity1 received OVA-specific IT or placebo alternately to airway challenge for 3 wk. To analyze the T cell-mediated mechanisms underlying IT in vivo, we elaborated the role of T-bet-expressing Th1 cells, T cell-derived @entity6 , and Ag-specific thymic as well as peripherally induced @entity7 (+) regulatory T (Treg) cells. IT ameliorated airway hyperresponsiveness and @entity2 in a chronic @entity5 model. Of note, IT even resulted in a regression of structural changes in the airways following chronic inhaled allergen exposure. Concomitantly, IT induced Th1 cells, @entity7 (+), and @entity6 -producing Treg cells. Detailed analyses revealed that thymic Treg cells crucially contribute to the effectiveness of IT by promoting @entity6 production in @entity7 -negative T cells. Together with the peripherally induced Ag-specific @entity7 (+) Treg cells, thymic @entity7 (+) Treg cells orchestrate the curative mechanisms of IT. Taken together, we demonstrate that IT is effective in a chronic @entity3 and dependent on @entity6 and thymic as well as peripherally induced Ag-specific Treg cells.

title: XXXX and Regulatory T Cells Cooperate in Allergen-Specific Immunotherapy To Ameliorate @entity3 .

answer: @entity6


abstract: UNASSIGNED: @entity0 studies demonstrated that allergen-specific immunotherapy (IT) represents an effective treatment for @entity3 . IT involves repeated administration of the sensitizing allergen, indicating a crucial contribution of T cells to its medicinal benefit. However, the underlying mechanisms of IT, especially in a @entity4 , are far from being definitive. In the current study, we sought to elucidate the suppressive mechanisms of IT in a @entity1 model of @entity3 . OVA-sensitized @entity1 were challenged with OVA or PBS for 4 wk. After development of @entity2 , @entity1 received OVA-specific IT or placebo alternately to airway challenge for 3 wk. To analyze the T cell-mediated mechanisms underlying IT in vivo, we elaborated the role of T-bet-expressing Th1 cells, T cell-derived @entity6 , and Ag-specific thymic as well as peripherally induced @entity7 (+) regulatory T (Treg) cells. IT ameliorated airway hyperresponsiveness and @entity2 in a chronic @entity5 model. Of note, IT even resulted in a regression of structural changes in the airways following chronic inhaled allergen exposure. Concomitantly, IT induced Th1 cells, @entity7 (+), and @entity6 -producing Treg cells. Detailed analyses revealed that thymic Treg cells crucially contribute to the effectiveness of IT by promoting @entity6 production in @entity7 -negative T cells. Together with the peripherally induced Ag-specific @entity7 (+) Treg cells, thymic @entity7 (+) Treg cells orchestrate the curative mechanisms of IT. Taken together, we demonstrate that IT is effective in a chronic @entity3 and dependent on @entity6 and thymic as well as peripherally induced Ag-specific Treg cells.

title: @entity6 and Regulatory T Cells Cooperate in Allergen-Specific Immunotherapy To Ameliorate XXXX .

answer: @entity3


abstract: Previous studies showed that decreased cerebral saturation during cardiac surgery is related to adverse postoperative outcome. Therefore, we investigated the influence of intraoperative events on cerebral tissue saturation in @entity0 undergoing cardiac surgery with cardiopulmonary bypass (CPB). A total of 52 adult @entity0 who underwent cardiac surgery using pulsatile CPB were included in this prospective explorative study. Cerebral tissue @entity1 saturation (SctO2) was measured in both the left and right cerebral hemisphere. Intraoperative events, involving interventions performed by anesthesiologist, surgeon, and clinical perfusionist, were documented. Simultaneously, in-line hemodynamic parameters (partial @entity1 pressure, partial @entity2 pressure, hematocrit, arterial blood pressure, and CPB flow rates) were recorded. Cerebral tissue saturation was affected by anesthetic induction (p < .001), placement of the sternal retractor (p < .001), and initiation (p < .001) as well as termination of CPB (p < .001). Placement (p < .001) and removal of the aortic cross-clamp (p = .026 for left hemisphere, p = .048 for right hemisphere) led to changes in cerebral tissue saturation. In addition, when placing the aortic crossclamp, hematocrit (p < .001) as well as arterial (p = .007) and venous (p < .001) partial @entity1 pressures changed. Cerebral tissue oximetry effectively identifies changes related to surgical events or vulnerable periods during cardiac surgery. Future studies are needed to identify methods of mitigating periods of reduced cerebral saturation.

title: Impact of Intraoperative Events on Cerebral Tissue Oximetry in XXXX Undergoing Cardiopulmonary Bypass.

answer: @entity0


abstract: OBJECTIVE: Quality of care monitoring is a key strategy for health policy. In Italy, the @entity4 Annals continuous monitoring and quality improvement initiative has been in place since 2006. Results after 8  years are now available. RESEARCH DESIGN AND METHODS: Quality of @entity1 care indicators during the years 2004-2011 were extracted from electronic medical records of 300 @entity1 clinics. From 200,000 to 500,000 @entity0 with @entity2 2 @entity1 were analyzed per year. Six process indicators, eight intermediate outcome indicators, seven indicators of treatment intensity/appropriateness, and a quality of care summary score (Q score) were evaluated. Previous studies documented that the risk of developing a new cardiovascular event was 80  % higher in @entity0 with a Q score <15 and 20  % higher in those with a score between 15 and 25, as compared to those with a score >25. RESULTS: The proportion of @entity0 with HbA1c  <=7  %, LDL @entity3 <100  mg/dl, and blood pressure >= 140/90  mmHg increased by 4.8, 21.9, and 10.0  %, respectively. Process and treatment intensity/appropriateness indicators consistently improved. The proportion of @entity0 with a Q score <15 decreased from 13.5 to 6.5  %, while those with a Q score >25 increased from 22.9 to 38.5  %. CONCLUSIONS: @entity4 Annals document the progress in quality of @entity1 care. Longitudinal improvements in Q score can translate into less cardiovascular events, with evident clinical and economic implications. @entity4 Annals represent a physician-led effort not requiring allocation of extra-economic resources, which is easy to implement and deeply rooted in routine clinical practice. They are a potential case model for other healthcare systems.

title: Trends over 8  years in quality of XXXX care: results of the @entity4 Annals continuous quality improvement initiative.

answer: @entity1


abstract: OBJECTIVE: Quality of care monitoring is a key strategy for health policy. In Italy, the @entity4 Annals continuous monitoring and quality improvement initiative has been in place since 2006. Results after 8  years are now available. RESEARCH DESIGN AND METHODS: Quality of @entity1 care indicators during the years 2004-2011 were extracted from electronic medical records of 300 @entity1 clinics. From 200,000 to 500,000 @entity0 with @entity2 2 @entity1 were analyzed per year. Six process indicators, eight intermediate outcome indicators, seven indicators of treatment intensity/appropriateness, and a quality of care summary score (Q score) were evaluated. Previous studies documented that the risk of developing a new cardiovascular event was 80  % higher in @entity0 with a Q score <15 and 20  % higher in those with a score between 15 and 25, as compared to those with a score >25. RESULTS: The proportion of @entity0 with HbA1c  <=7  %, LDL @entity3 <100  mg/dl, and blood pressure >= 140/90  mmHg increased by 4.8, 21.9, and 10.0  %, respectively. Process and treatment intensity/appropriateness indicators consistently improved. The proportion of @entity0 with a Q score <15 decreased from 13.5 to 6.5  %, while those with a Q score >25 increased from 22.9 to 38.5  %. CONCLUSIONS: @entity4 Annals document the progress in quality of @entity1 care. Longitudinal improvements in Q score can translate into less cardiovascular events, with evident clinical and economic implications. @entity4 Annals represent a physician-led effort not requiring allocation of extra-economic resources, which is easy to implement and deeply rooted in routine clinical practice. They are a potential case model for other healthcare systems.

title: Trends over 8  years in quality of @entity1 care: results of the XXXX Annals continuous quality improvement initiative.

answer: @entity4


abstract: AIMS: To examine contemporary rates of severe @entity2 (SH) and identify the effect of predictors of SH in a pediatric type 1 @entity1 population. METHODS: The national @entity1 register provided data on @entity0 residing in Denmark from 2008 to 2013 in this register-based population study. Robust Poisson regression models were applied. RESULTS: The study population [n  =  2,715 (50.9  % @entity0 ), mean (SD) age at onset; 8.1 (4.0) years, @entity1 duration; 5.6 (4.9) years] comprised 7,390 @entity0 -years of data and 561 events of SH. The overall incidence of SH was 7.6 per 100 @entity0 -years. The incidence rate peaked with 16.0 per 100 @entity0 -years in 2008 reaching a nadir of 4.9 in 2011. Overall, insulin pump reduced the rate of SH with 27  % compared to any pen treatment (P  =  0.003). When stratifying pen treatment, premixed insulin increased the rate of SH by 1.9-fold (P  =  0.0015) and NPH increased the rate by 1.6-fold (P  =  0.003) versus pump treatment, whereas long-acting insulin analogues were comparable with pump treatment (P  =  0.1485). We found no association of SH with glycemic control (P  >  0.05). CONCLUSIONS: A nationwide halving in rates of severe @entity2 was observed during the study period independent of the prevailing average HbA1c level. Changes in @entity1 care and successful educational programs may have influenced the lower incidence rate of severe @entity2 .

title: Nationwide reduction in the frequency of severe XXXX by half.

answer: @entity2


abstract: BACKGROUND: Opioid dependency currently affects over 2.5 million @entity0 in the United States and is increasing in incidence. Office-based opioid therapy with @entity2 - @entity1 provides greater @entity0 access to treatment and has significantly improved therapeutic outcomes. METHODS: We conducted a study of 100 consecutive @entity0 treated for @entity3 with @entity2 - @entity1 in a single provider's community-based internal medicine practice. The primary outcome measures were retention in therapy, wellness, and abstinence from ongoing drug use. Data were obtained from frequent physical examinations, self-report data, and periodic urine drug screening. RESULTS: The retention rate in therapy was 75%. A multidimensional evaluation of wellness improved in 75% of the @entity0 . Eighty-five percent reported no opiate relapse during therapy. CONCLUSION: Office-based opioid therapy with @entity2 - @entity1 has provided greater access to therapy with improved therapeutic outcomes. Our findings support the mounting literature that more @entity0 should be offered office-based opioid therapy for opioid dependency.

title: Opioid Addiction Treatment Using @entity2 - XXXX In A Community-Based Internal Medicine Practice.

answer: @entity1


abstract: BACKGROUND: Opioid dependency currently affects over 2.5 million @entity0 in the United States and is increasing in incidence. Office-based opioid therapy with @entity2 - @entity1 provides greater @entity0 access to treatment and has significantly improved therapeutic outcomes. METHODS: We conducted a study of 100 consecutive @entity0 treated for @entity3 with @entity2 - @entity1 in a single provider's community-based internal medicine practice. The primary outcome measures were retention in therapy, wellness, and abstinence from ongoing drug use. Data were obtained from frequent physical examinations, self-report data, and periodic urine drug screening. RESULTS: The retention rate in therapy was 75%. A multidimensional evaluation of wellness improved in 75% of the @entity0 . Eighty-five percent reported no opiate relapse during therapy. CONCLUSION: Office-based opioid therapy with @entity2 - @entity1 has provided greater access to therapy with improved therapeutic outcomes. Our findings support the mounting literature that more @entity0 should be offered office-based opioid therapy for opioid dependency.

title: Opioid Addiction Treatment Using XXXX - @entity1 In A Community-Based Internal Medicine Practice.

answer: @entity2


abstract: INTRODUCTION: @entity8 without @entity1 are rare and related to several conditions. @entity6 due to the use of anti- @entity5 drug are one of the rare causes. This case study is about @entity8 resulting from chronic use of anti- @entity5 drug. PRESENTATION OF CASE: A 26-year-old @entity0 was referred to our emergency department with a complaint of bilateral groin @entity2 and a 12-year history of irregular @entity7 use. The diagnosis was @entity8 due to irregular long-term @entity7 use. One-stage bilateral dynamic hip screw osteosynthesis was performed. After 2 years of follow up, good result was obtained. DISCUSSION: There are several risk factors for insufficiency @entity4 , and antiepileptic drug related @entity3 is one of the reason. These drugs have negative effect on bone methabolism and bone mineral density. CONCLUSION: To our knowledge, this is the first case in the literature of bilateral femoral neck insufficiency @entity4 due to chronic @entity7 use. Joint and @entity2 with a history of long-term use of anti- @entity5 drug should be investigated carefully, and insufficiency @entity4 should be kept in mind.

title: XXXX secondary to chronic @entity7 use treated by bilateral dynamic hip screw: A case report.

answer: @entity8


abstract: INTRODUCTION: @entity8 without @entity1 are rare and related to several conditions. @entity6 due to the use of anti- @entity5 drug are one of the rare causes. This case study is about @entity8 resulting from chronic use of anti- @entity5 drug. PRESENTATION OF CASE: A 26-year-old @entity0 was referred to our emergency department with a complaint of bilateral groin @entity2 and a 12-year history of irregular @entity7 use. The diagnosis was @entity8 due to irregular long-term @entity7 use. One-stage bilateral dynamic hip screw osteosynthesis was performed. After 2 years of follow up, good result was obtained. DISCUSSION: There are several risk factors for insufficiency @entity4 , and antiepileptic drug related @entity3 is one of the reason. These drugs have negative effect on bone methabolism and bone mineral density. CONCLUSION: To our knowledge, this is the first case in the literature of bilateral femoral neck insufficiency @entity4 due to chronic @entity7 use. Joint and @entity2 with a history of long-term use of anti- @entity5 drug should be investigated carefully, and insufficiency @entity4 should be kept in mind.

title: @entity8 secondary to chronic XXXX use treated by bilateral dynamic hip screw: A case report.

answer: @entity7


abstract: UNASSIGNED: A major debate in the mental-rotation literature concerns the question of whether objects are represented holistically during rotation. Effects of object complexity on rotational speed are considered strong evidence against such holistic representations. In Experiment 1, such an effect of object complexity was markedly present. A closer look on individual performance patterns, however, revealed that only some @entity0 showed this effect. For others, rotational speed was independent of object complexity. The assumption that these fast-rotating @entity0 use a holistic representation that equally well holds simple and complex objects would explain these results. Taking error rates into account disproved this explanation: Fast @entity0 simply committed more errors in those conditions for which careful @entity0 invested more rotation time. Whether this speed-accuracy trade-off is a stable personality trait or a somewhat flexible strategic choice was examined in Experiments 2 and 3. In Experiment 2, @entity0 received monetary incentives that encouraged them to minimize errors. In line with a certain degree of flexible strategic control over speed-accuracy trade-offs, a large majority of @entity0 showed effects of object complexity on rotational speed. When, in contrast, time pressure was induced in Experiment 3, error rates increased considerably and most @entity0 ' rotational speed became independent of object complexity. Our results indicate that all our @entity0 performed @entity1 on a nonholistic representation and that apparent holistic processing strategies in @entity1 (and potentially also in other spatial tasks) might actually be speed-accuracy trade-offs in disguise. (PsycINFO Database Record

title: Fast and careless or careful and slow? Apparent holistic processing in XXXX is explained by speed-accuracy trade-offs.

answer: @entity1


abstract: UNASSIGNED: Global patterns of @entity2 ( @entity2 ) in chromosomes are required to understand the dynamics of genome organization and complexity. For this study, analysis was performed using the Affymetrix Genome-Wide @entity0 SNP Array 6.0 chip and CytoScan High-Density arrays. We identified a total of 44 109 @entity2 from 1715 genomes with a mean of 25 @entity2 in an individual, which established the first drafts of population-specific @entity1 maps providing a rationale for prioritizing chromosomal regions. About 19 905 ancient @entity2 were identified across all chromosomes and populations at varying frequencies. @entity1 count, and sometimes @entity1 size, contributed to the bulk @entity1 size of the chromosome. Population specific lengthening and shortening of chromosomal length was observed. Sex bias for @entity1 presence was largely dependent on ethnicity. Lower @entity1 inheritance rate was observed for India, compared to YRI and CEU. A total of 33 candidate @entity1 hotspots from 5382 copy number (CN) variable region (CNVR) clusters were identified. Population specific @entity1 distribution patterns in p and q arms disturbed the assumption that @entity1 counts in the p arm are less common compared to long arms, and the @entity1 occurrence and distribution in chromosomes is length independent. This study unraveled the force of independent evolutionary dynamics on genome organization and complexity across chromosomes and populations.

title: Global patterns of large XXXX in the @entity0 genome reveal complexity in chromosome organization.

answer: @entity2


abstract: UNASSIGNED: Global patterns of @entity2 ( @entity2 ) in chromosomes are required to understand the dynamics of genome organization and complexity. For this study, analysis was performed using the Affymetrix Genome-Wide @entity0 SNP Array 6.0 chip and CytoScan High-Density arrays. We identified a total of 44 109 @entity2 from 1715 genomes with a mean of 25 @entity2 in an individual, which established the first drafts of population-specific @entity1 maps providing a rationale for prioritizing chromosomal regions. About 19 905 ancient @entity2 were identified across all chromosomes and populations at varying frequencies. @entity1 count, and sometimes @entity1 size, contributed to the bulk @entity1 size of the chromosome. Population specific lengthening and shortening of chromosomal length was observed. Sex bias for @entity1 presence was largely dependent on ethnicity. Lower @entity1 inheritance rate was observed for India, compared to YRI and CEU. A total of 33 candidate @entity1 hotspots from 5382 copy number (CN) variable region (CNVR) clusters were identified. Population specific @entity1 distribution patterns in p and q arms disturbed the assumption that @entity1 counts in the p arm are less common compared to long arms, and the @entity1 occurrence and distribution in chromosomes is length independent. This study unraveled the force of independent evolutionary dynamics on genome organization and complexity across chromosomes and populations.

title: Global patterns of large @entity2 in the XXXX genome reveal complexity in chromosome organization.

answer: @entity0


abstract: Seven @entity0 with @entity3 underwent intermittent hemodialysis for five to 37 months (111 @entity0 -months on a twice-weekly basis) employing arteriovenous Teflon-Silastic cannulas and the modified two-layer Kiil hemodialyzer. A single-pass 37 degrees C. dialysate system has been used. One @entity0 died of an indirectly related cause. All other @entity0 have been successfully rehabilitated and now carry on normal activity of moderate sedentary type. Complications included recurring @entity4 and clotting of arteriovenous cannulas. @entity1 and @entity5 were common complications requiring careful control. @entity9 was noted in five of the seven @entity0 but was of clinical significance in only one @entity0 . @entity7 , @entity2 and @entity8 also occurred in this @entity0 . @entity10 with @entity6 developed in two @entity0 . The degree of rehabilitation and psychological adjustment achieved by this group of @entity0 strongly indicates the need for expansion of dialysis facilities and further research into the medical and economic aspects of dialysis.

title: Intermittent hemodialysis in terminal XXXX .

answer: @entity3


abstract: BACKGROUND: Nowadays there is still a lack of effective method to evaluate @entity1 . To distinguish @entity0 with and without @entity2 after @entity1 reliably, this study proposes a new Post-Stroke @entity2 Scale (PSDS). METHODS: PSDS was developed based on various @entity2 scales and clinician experiences. 158 @entity1 @entity0 who were able to finish PSDS and @entity2 ( @entity2 ) were recruited. Cronbach a, Spearman rank coefficient and Kruskal-Wallis test were respectively used to examine reliability, internal consistency and discriminate validity. Then the Receiver Operating Characteristic (ROC) curve was used to determine the ability of scale and categorized scales to the range of @entity2 . Finally, the factors of the PSDS were classified by average clustering analysis. RESULTS: The Cronbach a of PSDS was 0.797 (95% CI) indicted a good reliability. The Spearman correlation coefficient between PSDS and @entity2 was 0.822 (P<0.001) showed an excellent congruent validity. The discriminate validity displayed significant difference between @entity0 with and without @entity2 (P<0.001). 6/24 was set to be the cut-off value by ROC analysis. Moreover, the different severity was distinguished by the value 6/24, 15/24 and 17/24. LIMITATIONS: The small sample size maybe the main limitation, the larger sample used in different fields according sex, age and side-lesion was needed to verity the results. The cut off value calculated by ROC curve maybe react the severity of the disease to some extent, but it is not absolute. CONCLUSIONS: PSDS is a valid, reliable and specific tool for evaluating @entity1 @entity0 and can be conveniently utilized.

title: Reliability and validity of a new XXXX scale in Chinese population.

answer: @entity1


abstract: INTRODUCTION: @entity1 involving the parotid are predominantly primary with metastatic lesions forming a miniscule population. @entity6 metastasizing to the parotid is extremely rare and hence can often be mistaken for the more common primary @entity10 . PRESENTATION OF CASE: A 59-year-old male presented with a swelling in the left parotid region. Fine needle aspiration cytology was suggestive of myoepithelial predominant @entity8 . A superficial parotidectomy performed revealed a @entity1 composed of rhabdoid cells with abundant finely granular eosinophilic cytoplasm raising a possibility of @entity11 . Immunohistochemistry for myoepithelial markers was negative. A critical review elicited a history of surgical excision of a recurrent @entity9 twice. A possibility of @entity0 was considered and a second panel of immunomarkers demonstrated @entity7 and epithelial membrane antigen positivity. Neuroimaging studies demonstrated a space occupying lesion in the frontal lobe suggestive of a recurrent/ @entity2 . In view of the history, neuroradiology, histopathology and immunohistochemistry, a final diagnosis of metastatic @entity9 to the parotid was rendered. DISCUSSION: Morphologically, metastatic @entity9 may mimic a primary or @entity3 , @entity5 and @entity4 . Accurate diagnosis can be made by careful clinical evaluation and histopathological examination of the @entity1 . These @entity1 are composed of rhabdomyoblast like cells with abundant eosinophilic cytoplasm. The present case demonstrated characteristic histopathological features confirmed by immunohistochemistry. CONCLUSION: @entity9 is an aggressive @entity1 with a high propensity to recur and metastasize. The present case highlights the importance of clinical, radiological and histopathological correlation to accurately diagnose these rare entities.

title: Metastatic @entity9 of the parotid - Mimicking primary XXXX .

answer: @entity10


abstract: INTRODUCTION: @entity1 involving the parotid are predominantly primary with metastatic lesions forming a miniscule population. @entity6 metastasizing to the parotid is extremely rare and hence can often be mistaken for the more common primary @entity10 . PRESENTATION OF CASE: A 59-year-old male presented with a swelling in the left parotid region. Fine needle aspiration cytology was suggestive of myoepithelial predominant @entity8 . A superficial parotidectomy performed revealed a @entity1 composed of rhabdoid cells with abundant finely granular eosinophilic cytoplasm raising a possibility of @entity11 . Immunohistochemistry for myoepithelial markers was negative. A critical review elicited a history of surgical excision of a recurrent @entity9 twice. A possibility of @entity0 was considered and a second panel of immunomarkers demonstrated @entity7 and epithelial membrane antigen positivity. Neuroimaging studies demonstrated a space occupying lesion in the frontal lobe suggestive of a recurrent/ @entity2 . In view of the history, neuroradiology, histopathology and immunohistochemistry, a final diagnosis of metastatic @entity9 to the parotid was rendered. DISCUSSION: Morphologically, metastatic @entity9 may mimic a primary or @entity3 , @entity5 and @entity4 . Accurate diagnosis can be made by careful clinical evaluation and histopathological examination of the @entity1 . These @entity1 are composed of rhabdomyoblast like cells with abundant eosinophilic cytoplasm. The present case demonstrated characteristic histopathological features confirmed by immunohistochemistry. CONCLUSION: @entity9 is an aggressive @entity1 with a high propensity to recur and metastasize. The present case highlights the importance of clinical, radiological and histopathological correlation to accurately diagnose these rare entities.

title: Metastatic XXXX of the parotid - Mimicking primary @entity10 .

answer: @entity9


abstract: OBJECTIVES: To assess the effect of a nutrition education intervention on nutritional factors and oxidative stress during treatment of @entity0 . DESIGN: Nonrandomized clinical trial conducted in 2010-2011, including an evaluation at baseline and after 12  months. @entity1 : @entity1 from Brazil who had @entity0 , divided into an intervention group (IG) (n  =  18) and comparison group (n  =  75). INTERVENTION: To increase intake of fruits and vegetables and reduce red and processed meats, via telephone and printed materials. MAIN OUTCOME MEASURES: Food intake, anthropometry, and levels of lipid @entity2 , @entity4 proteins, @entity3 , and ferric reducing antioxidant power. ANALYSES: Chi-square, Mann-Whitney or t tests for baseline data; Wilcoxon or paired t tests for intra-group outcomes, linear regression models, and Bonferroni multiplicity adjustment. RESULTS: The researchers observed an increase in fruit and vegetable intake, reduction in red and processed meat intake, no change in body weight, and an increase in @entity3 in the IG over the comparison group. However, after Bonferroni adjustment, only the consumption of fruits and vegetables and fruit was significantly higher in IG. CONCLUSIONS AND IMPLICATIONS: This study presents improved dietary changes after a theory-driven nutrition education intervention. Although the sample size is small, it has proven to be clinically relevant.

title: Nutrition education intervention for @entity1 with XXXX : effect on nutritional factors and oxidative stress.

answer: @entity0


abstract: OBJECTIVES: To assess the effect of a nutrition education intervention on nutritional factors and oxidative stress during treatment of @entity0 . DESIGN: Nonrandomized clinical trial conducted in 2010-2011, including an evaluation at baseline and after 12  months. @entity1 : @entity1 from Brazil who had @entity0 , divided into an intervention group (IG) (n  =  18) and comparison group (n  =  75). INTERVENTION: To increase intake of fruits and vegetables and reduce red and processed meats, via telephone and printed materials. MAIN OUTCOME MEASURES: Food intake, anthropometry, and levels of lipid @entity2 , @entity4 proteins, @entity3 , and ferric reducing antioxidant power. ANALYSES: Chi-square, Mann-Whitney or t tests for baseline data; Wilcoxon or paired t tests for intra-group outcomes, linear regression models, and Bonferroni multiplicity adjustment. RESULTS: The researchers observed an increase in fruit and vegetable intake, reduction in red and processed meat intake, no change in body weight, and an increase in @entity3 in the IG over the comparison group. However, after Bonferroni adjustment, only the consumption of fruits and vegetables and fruit was significantly higher in IG. CONCLUSIONS AND IMPLICATIONS: This study presents improved dietary changes after a theory-driven nutrition education intervention. Although the sample size is small, it has proven to be clinically relevant.

title: Nutrition education intervention for XXXX with @entity0 : effect on nutritional factors and oxidative stress.

answer: @entity1