abstract: The effect of maternal @entity2 deficiency on the morphological changes in the dendritic growth of Purkinje cells of progeny was studied at four different ages (12, 15, 21, and 50 days) of postnatal development. By day 10, @entity1 pups in the deficient groups (0.6 or 1.0 mg @entity3 . @entity4 /kg diet) began to show gross @entity0 and before weaning approximately 12% of the pups in the 0.6 group had died. At each age studied, body weights were less and brain-body weight ratios were greater in the deficient groups compared to control (7.0 mg @entity3 . @entity4 /kg diet) groups. Morphological changes of the Purkinje cell dendritic field, as determined from camera lucida drawings of Golgi-Cox impregnated cells of the mid-sagittal vermis, indicated significantly smaller width, height and area in the deficient groups compared to the control. Stereological measurements showed that dendritic branching density was significantly less in the 0.6 group compared with the 1.0 and 7.0 groups. The total length of Purkinje cell dendrites per cell was significantly reduced in the deficient groups compared to the 7.0 group. Qualitative analyses of photomicrographs of Purkinje cells indicated more dendritic and somatic aberrations in the deficient groups than in the control. Dendritic trees were larger in size and more complex in the 7.0 group compared to the deficient groups. The findings indicate that maternal @entity2 deficiency interferes with normal development of the Purkinje cell dendrites.

title: Effects of XXXX deficiency on morphological changes in dendritic trees of Purkinje cells in developing cerebellum of @entity1 .

answer: @entity2


abstract: The effect of maternal @entity2 deficiency on the morphological changes in the dendritic growth of Purkinje cells of progeny was studied at four different ages (12, 15, 21, and 50 days) of postnatal development. By day 10, @entity1 pups in the deficient groups (0.6 or 1.0 mg @entity3 . @entity4 /kg diet) began to show gross @entity0 and before weaning approximately 12% of the pups in the 0.6 group had died. At each age studied, body weights were less and brain-body weight ratios were greater in the deficient groups compared to control (7.0 mg @entity3 . @entity4 /kg diet) groups. Morphological changes of the Purkinje cell dendritic field, as determined from camera lucida drawings of Golgi-Cox impregnated cells of the mid-sagittal vermis, indicated significantly smaller width, height and area in the deficient groups compared to the control. Stereological measurements showed that dendritic branching density was significantly less in the 0.6 group compared with the 1.0 and 7.0 groups. The total length of Purkinje cell dendrites per cell was significantly reduced in the deficient groups compared to the 7.0 group. Qualitative analyses of photomicrographs of Purkinje cells indicated more dendritic and somatic aberrations in the deficient groups than in the control. Dendritic trees were larger in size and more complex in the 7.0 group compared to the deficient groups. The findings indicate that maternal @entity2 deficiency interferes with normal development of the Purkinje cell dendrites.

title: Effects of @entity2 deficiency on morphological changes in dendritic trees of Purkinje cells in developing cerebellum of XXXX .

answer: @entity1


abstract: OBJECTIVES: @entity2 ( @entity2 ) is characterized by relative preservation of the medial temporal lobe compared with @entity1 ( @entity1 ). The differential involvement of the hippocampal subfields in both diseases has not been clearly established, however. We aim to investigate hippocampal subfield differences in  vivo in a clinical cohort of @entity2 and @entity1 subjects. METHODS: 104 @entity0 (35 DLBs, 36 ADs, and 35 healthy comparison [HC] subjects) underwent clinical assessment and 3T T1-weighted imaging. A Bayesian model implemented in Freesurfer was used to automatically segment the hippocampus and its subfields. We also examined associations between hippocampal subfields and tests of memory function. RESULTS: Both the @entity1 and @entity2 groups demonstrated significant atrophy of the total hippocampus relative to HC but the @entity2 group was characterized by preservation of the cornu ammonis 1 (CA1), fimbria, and fissure. In contrast, all the hippocampal subfields except the fissure were significantly atrophied in @entity1 compared with both @entity2 and HC groups. Among @entity2 subjects, CA1 was correlated with the Recent Memory score of the CAMCOG and Delayed Recall subscores of the HVLT. CONCLUSIONS: @entity2 is characterized by milder hippocampal atrophy that was accompanied by preservation of the CA1. The CA1 was also associated with memory function in @entity2 . Our findings highlight the promising role of hippocampal subfield volumetry, particularly that of the CA1, as a biomarker for the distinction between @entity1 and @entity2 .

title: Differential Atrophy of Hippocampal Subfields: A Comparative Study of Dementia with Lewy Bodies and XXXX .

answer: @entity1


abstract: @entity1 account for 0.7-1.8% of all gynecologic @entity1 . Among them, @entity2 are predominant (40-53%). @entity0 with @entity1 have better prognosis than those with single disseminated @entity1 . We present 10 @entity0 with @entity2 who were treated at the Chemotherapy Department of the Medical University of Lodz in 2009-2013. The most often reported symptom of the disease was @entity4 (6 @entity0 ). The range of the @entity0 ' age was 48-62 and the median age was 56. Five @entity0 had stage I of @entity2 , single @entity0 had stage IIA, IIB and IIIB, 2 @entity0 had stage IIIC. Three @entity0 had I, 5 - II, and 2 - III stage of @entity3 . All @entity0 had endometrioid type of @entity3 , 7 of them had also the same histological type of @entity2 . All @entity0 had adjuvant chemotherapy because of @entity2 , none of them had adjuvant radiotherapy. One @entity0 was lost to follow up. For other @entity0 a median follow up was 13 months (range: 3-53 months). One @entity0 experienced relapse, all @entity0 are alive. @entity2 are usually diagnosed at an earlier stage, have lower histological grade and better prognosis than @entity1 . The most common histological type of both @entity2 is @entity5 . The first symptoms reported by our @entity0 and the course of the disease were concordant with data from the literature.

title: Synchronous primary XXXX : a series of cases and a review of literature.

answer: @entity2


abstract: BACKGROUND: @entity6 following @entity3 ( @entity3 ) sustained in military service, while common, is highly challenging to treat with existing pharmacologic and non-pharmacologic interventions and may be complicated by co-morbid posttraumatic stress. Recently, a novel form of brainwave-based intervention known as the Flexyx Neurotherapy System (FNS) that involves minute pulses of electromagnetic energy stimulation of brainwave activity has been suggested as a means to address symptoms of @entity3 . This study reports on a clinical series of @entity0 with @entity6 following service-connected @entity3 treated with FNS. METHODS: Nine veterans of the wars in Afghanistan and Iraq with moderate to severe @entity6 following service-connected @entity3 and complicated by posttraumatic stress symptoms were treated in 20 individual FNS sessions at the Brain Wellness and Biofeedback Center of Washington (in Bethesda, Maryland, USA). They periodically completed measures including the Brief Pain Inventory-Headache (BPI-HA) past week worst and average @entity4 ratings, the @entity5 Checklist-Military version ( @entity7 -M), and individual treatment session numerical rating scale (NRS) for degree of @entity2 . Data analyses included beginning to end of treatment t-test comparisons for the BPI-HA, @entity7 -M, and @entity2 NRS. RESULTS: All beginning to end of treatment t-test comparisons for the BPI-HA, @entity7 -M, and @entity2 NRS indicated statistically significant decreases. All but one @entity0 experienced reduction in @entity1 along with reductions in posttraumatic stress and perceived @entity2 , with a subset experiencing virtual elimination of @entity1 . One @entity0 obtained modest @entity1 relief but no improvement in posttraumatic stress or @entity2 . CONCLUSIONS: FNS may be a potentially efficacious treatment for chronic @entity1 sustained in military service. Further research is needed to investigate the efficacy of FNS within a randomized, controlled clinical trial, to identify characteristics of those most likely to respond, and to explore underlying mechanisms that may contribute to improvement.

title: Neurotherapy for @entity6 following XXXX .

answer: @entity3


abstract: BACKGROUND: @entity6 following @entity3 ( @entity3 ) sustained in military service, while common, is highly challenging to treat with existing pharmacologic and non-pharmacologic interventions and may be complicated by co-morbid posttraumatic stress. Recently, a novel form of brainwave-based intervention known as the Flexyx Neurotherapy System (FNS) that involves minute pulses of electromagnetic energy stimulation of brainwave activity has been suggested as a means to address symptoms of @entity3 . This study reports on a clinical series of @entity0 with @entity6 following service-connected @entity3 treated with FNS. METHODS: Nine veterans of the wars in Afghanistan and Iraq with moderate to severe @entity6 following service-connected @entity3 and complicated by posttraumatic stress symptoms were treated in 20 individual FNS sessions at the Brain Wellness and Biofeedback Center of Washington (in Bethesda, Maryland, USA). They periodically completed measures including the Brief Pain Inventory-Headache (BPI-HA) past week worst and average @entity4 ratings, the @entity5 Checklist-Military version ( @entity7 -M), and individual treatment session numerical rating scale (NRS) for degree of @entity2 . Data analyses included beginning to end of treatment t-test comparisons for the BPI-HA, @entity7 -M, and @entity2 NRS. RESULTS: All beginning to end of treatment t-test comparisons for the BPI-HA, @entity7 -M, and @entity2 NRS indicated statistically significant decreases. All but one @entity0 experienced reduction in @entity1 along with reductions in posttraumatic stress and perceived @entity2 , with a subset experiencing virtual elimination of @entity1 . One @entity0 obtained modest @entity1 relief but no improvement in posttraumatic stress or @entity2 . CONCLUSIONS: FNS may be a potentially efficacious treatment for chronic @entity1 sustained in military service. Further research is needed to investigate the efficacy of FNS within a randomized, controlled clinical trial, to identify characteristics of those most likely to respond, and to explore underlying mechanisms that may contribute to improvement.

title: Neurotherapy for XXXX following @entity3 .

answer: @entity6


abstract: OBJECTIVE: The functional outcome following @entity1 repair is as important as the cosmetic outcome. Currently, structured scoring systems, @entity0 questionnaires and evaluations of photographs and uroflowmetry are used to assess the results of @entity1 repair. In the present study, we assessed the outcomes of two-stage @entity1 repair using Hypospadias Objective Scoring Evaluation-HOSE and measures of uroflowmetry. MATERIAL AND METHODS: Over a period of eight years, from January 1997 to December 2004, 126 @entity1 @entity0 were treated, 90 of these @entity0 received two-stage repairs and 36 @entity0 received single-stage repairs. HOSE questionnaire and uroflowmetry data were obtained to evaluate the long-term outcome of the two-stage @entity1 repairs. RESULTS: The age at the time of assessment ranged from 8 to 23 years-old, with a mean follow-up time of 39.78 months. Thirty-five @entity0 had @entity2 , and 20 had @entity1 . Of the 55 @entity0 who received complete two-stage @entity1 repair and agreed to participate in the study, nineteen @entity0 had acceptable HOSE scores and 36 @entity0 had non-acceptable scores. The uroflow rates of 43 of the subjects were below the fifth percentile in three @entity0 , equivocal (between the 5(th) and 25(th) percentile) in four @entity0 and above the 25(th) percentile in 36 @entity0 . CONCLUSION: Two-stage repair is a suitable technique for all types of @entity1 with varying outcomes. HOSE and uroflowmetry are simple, easy, non-invasive and non-expensive tools for objectively assessing the long-term outcomes of @entity1 repair.

title: Cosmetic and functional outcomes of two-stage XXXX repair: an objective scoring evaluation and uroflowmetry.

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to determine whether @entity2 (AO) can be used as a routine procedure in a physician's office to detect sperm deoxyribonucleic acid (DNA) fragmentation in @entity0 with varicoceles. MATERIAL AND METHODS: Forty-five @entity0 with a mean age of 30.4 years, who had been diagnosed with varicoceles by physical examination and 30 healthy males with a mean age of 28.3 years and without any signs of varicoceles were included in this study. Doppler Ultrasonography was performed to each individual in addition to physical examination. Semen analyses were performed by the same biologist. Sperm morphology was evaluated according to the World Health Organization (WHO) criteria and Kruger's strict criteria. After routine semen analysis, the samples were fixed separately for further examination with AO staining. RESULTS: In routine semen analyses, total sperm count, total motile sperm count, and fast direct forward motile and direct forward motile sperm counts were significantly lower in @entity0 with varicoceles, and the immotile sperm count was significantly higher in @entity0 with varicoceles compared to the control group. Kruger's examination revealed a lower sperm count with normal morphology in @entity0 with varicoceles. After AO staining, the ratio of spermatozoa demonstrating red and green coloration were 6.5  11.0% and 93.5  11.0%, respectively in the varicocele group and 1.0  1.0% and 99.0  1.0%, respectively in the control group (p<0.001). CONCLUSION: Semen analysis using AO staining can be performed under a clinician's office conditions with a fluorescent microscope without any additional equipment. Further studies are needed to validate the AO staining with more extensively used and well-known methods. Therefore, AO staining can be used as a simple and reliable method that can be performed daily in a physician's office in @entity1 and andrology clinics.

title: The effect of varicocele on sperm morphology and DNA maturity: does XXXX staining facilitate diagnosis?

answer: @entity2


abstract: OBJECTIVE: The aim of the study was to compare the efficacy and cost-effectiveness of single-session aspiration and @entity4 sclerotherapy with laparoscopic de-roofing in the management of symptomatic @entity1 . MATERIAL AND METHODS: Between March 2010 and December 2012, @entity0 with @entity1 presenting with pressure and @entity2 symptoms were divided into two groups. In Group 1 following local anesthetic administration, single session percutaneous aspiration with 95% @entity4 sclerotherapy (n=38) and in Group 2 transperitoneal laparoscopic de-roofing under general anesthesia (n=42) were performed. The data were evaluated retrospectively and demographic characteristics, duration of operation and hospitalization, complication rates, cost effectiveness, radiological and symptomatic success rates at six month- follow-up were compared between the two groups. RESULTS: The mean age and gender of the @entity0 , cyst diamater, side and localization of the cyst and indications for intervention were similar in two groups. The median course of treatment and hospitalization were signifcantly decreased in Group 1 (respectively 33 min versus 59 min and 6 hours versus 24 hours, p<0.001). As complications in Group 1 fever in two @entity0 (5.3%) and in Group 2 bleeding requiring transfusion in one @entity0 (2.4%) were observed (p=0.495). Total cost was calculated as   131.7 in Group 1 and   729.8 in Group 2. After the sixth month follow-up control radiological success rates were found to be signifcantly higher in Group 2, while symptomatic success rate is similar in both groups (63.2% versus 95.2%, p<0.001; 94.7% versus 97.6%, p=0.498, respectively). CONCLUSION: Single-session percutaneous aspiration with @entity3 sclerotherapy and laparoscopic de-roofing are safe and effective methods in the treatment of symptomatic @entity1 . While radiological recurrence rate was higher in single session percutaneous aspiration with @entity3 sclerotherapy, however similar symptomatic recurrence rates were seen with laparoscopy. Therefore single session percutaneous aspiration combined with @entity3 sclerotherapy seems to be an important option in the treatment of @entity1 when considering the duration of the operation, hospitalization and total costs of the process.

title: Comparison of single-session aspiration and @entity4 sclerotherapy with laparoscopic de-roofing in the management of symptomatic XXXX .

answer: @entity1


abstract: OBJECTIVE: The aim of the study was to compare the efficacy and cost-effectiveness of single-session aspiration and @entity4 sclerotherapy with laparoscopic de-roofing in the management of symptomatic @entity1 . MATERIAL AND METHODS: Between March 2010 and December 2012, @entity0 with @entity1 presenting with pressure and @entity2 symptoms were divided into two groups. In Group 1 following local anesthetic administration, single session percutaneous aspiration with 95% @entity4 sclerotherapy (n=38) and in Group 2 transperitoneal laparoscopic de-roofing under general anesthesia (n=42) were performed. The data were evaluated retrospectively and demographic characteristics, duration of operation and hospitalization, complication rates, cost effectiveness, radiological and symptomatic success rates at six month- follow-up were compared between the two groups. RESULTS: The mean age and gender of the @entity0 , cyst diamater, side and localization of the cyst and indications for intervention were similar in two groups. The median course of treatment and hospitalization were signifcantly decreased in Group 1 (respectively 33 min versus 59 min and 6 hours versus 24 hours, p<0.001). As complications in Group 1 fever in two @entity0 (5.3%) and in Group 2 bleeding requiring transfusion in one @entity0 (2.4%) were observed (p=0.495). Total cost was calculated as   131.7 in Group 1 and   729.8 in Group 2. After the sixth month follow-up control radiological success rates were found to be signifcantly higher in Group 2, while symptomatic success rate is similar in both groups (63.2% versus 95.2%, p<0.001; 94.7% versus 97.6%, p=0.498, respectively). CONCLUSION: Single-session percutaneous aspiration with @entity3 sclerotherapy and laparoscopic de-roofing are safe and effective methods in the treatment of symptomatic @entity1 . While radiological recurrence rate was higher in single session percutaneous aspiration with @entity3 sclerotherapy, however similar symptomatic recurrence rates were seen with laparoscopy. Therefore single session percutaneous aspiration combined with @entity3 sclerotherapy seems to be an important option in the treatment of @entity1 when considering the duration of the operation, hospitalization and total costs of the process.

title: Comparison of single-session aspiration and XXXX sclerotherapy with laparoscopic de-roofing in the management of symptomatic @entity1 .

answer: @entity4


abstract: PURPOSE: The impact of multileaf collimator (MLC) design and IMRT technique on plan quality and delivery improvements for head-and-neck and @entity3 @entity0 is compared in a planning study. MATERIAL AND METHODS: Ten previously treated @entity0 (5 head-and-neck, 5 @entity3 ) were re-planned for step-and-shoot IMRT (ssIMRT), sliding window IMRT (dMLC) and VMAT using the MLCi2 without (-) and with (+) interdigitation and the Agility-MLC attached to an Elekta 6MV linac. This results in nine plans per @entity0 . Consistent @entity0 individual optimization parameters are used. Plans are generated using the research tool Hyperion V2.4 (equivalent to Elekta Monaco 3.2) with hard constraints for critical structures and objectives for target structures. For VMAT plans, the improved segment shape optimization is used. Critical structures are evaluated based on QUANTEC criteria. @entity1 coverage is compared by EUD, Dmean, homogeneity and conformity. Additionally, MU/plan, treatment times and number of segments are evaluated. RESULTS: As constrained optimization is used, all plans fulfill the hard constraints. Doses to critical structures do not differ more than 1Gy between the nine generated plans for each @entity0 . Only larynx, parotids and eyes differ up to 1.5Gy (Dmean or Dmax) or 7  % (volume-constraint) due to (1) increased scatter, (2) not avoiding structures when using the full range of @entity2 and (3) improved leaf sequencing with advanced segment shape optimization for VMAT plans. EUD, Dmean, homogeneity and conformity are improved using the Agility-MLC. However, @entity1 coverage is more affected by technique. MU increase with the use of dMLC and VMAT, while the MU are reduced by using the Agility-MLC. Fastest treatments are always achieved using Agility-MLC, especially in combination with VMAT. CONCLUSION: Fastest treatments with the best @entity1 coverage are found for VMAT plans with Agility-MLC, achieving the same sparing of healthy tissue compared to the other combinations of ssIMRT, dMLC and VMAT with either MLCi2(-/+) or Agility.

title: Impact of MLC properties and IMRT technique in XXXX and head-and-neck treatments.

answer: @entity3


abstract: A 2-year-old @entity0 was admitted to Chugoku Rosai Hospital one hour after a car accident on July 16, 1978. On admission she was conscious and no physical or @entity1 was found. However, 2 hours and a half after the accident, she was attacked suddenly by generalized @entity5 , and then became comatose with @entity4 . Bilateral horizontal nystagmus to the left, rhythmic constriction and dilation of the pupils reacting to light, and flaccid @entity8 were recognized. Plain skull films revealed a linear @entity3 in the right posterior fossa, which crossed the transverse this region. A burr hole was made in the left posterior fossa, and slightly xanthochromic fluid, 30 to 40 microliter in volume, under high pressure was evacuated from the subdural space. A burr hole on the right side disclosed no abnormality. Spontaneous respiration returned immediately and consciousness became clear 5 hours after the surgery. No @entity2 was detect and postoperative EEG was normal. She was discharged from the hospital on July 27, 1978. Ten cases of acute @entity9 in the posterior fossa, including the present case, were analyzed. This lesion is able to be cured completely by a simple operation even in @entity7 with @entity4 , if diagnosis made promptly and the surgery is carried out without delay. In cases of acute @entity6 , it is quite important to have a possibility of the infratentorial lesion in mind and to find it with the aids of plain skull film of Towne's view, CT scan, and VAG if necessary.

title: [Acute XXXX in the posterior fossa (author's transl)].

answer: @entity9


abstract: A previous study indicated that the mortality rate after severe @entity5 (Glasgow @entity6 score less than or equal to 7) was higher on each of the first 2 days after @entity4 (early deaths) than on any subsequent day (late deaths). The low Glasgow @entity6 scores, high incidence of unreactive pupils, and refractoriness to treatment of @entity0 dying within 48 hours of @entity4 suggested that many such @entity0 had sustained irreversible @entity8 . To determine the extent to which events at impact sealed the fate of those dying early deaths after @entity5 , we compared the pathology of cases of early and late death. Of 2000 @entity0 with @entity5 admitted to the neurosurgery service during a 6-year period, there were 138 deaths and 56 autopsies. Seventy-two per cent of the @entity0 who died during the first 48 hours after @entity4 had widespread homogenizing @entity2 of neuron or direct brain stem @entity4 , considered to represent irreversible @entity3 . Only 19% of those dying later deaths had these pathological changes. @entity0 with severe homogenizing @entity2 or direct brain stem damage were usually injured in high speed motor vehicle accidents and had low Glasgow @entity6 scores and unreactive pupils on admission to the hospital. They usually did not have @entity7 , but had @entity1 . @entity0 dying without homogenizing @entity2 or direct brain stem @entity4 usually were injured by blows or falls, usually had @entity7 , and less often had unreactive pupils and low Glasgow @entity6 scores on admission. The findings suggest that there is a significant irreducible mortality rate after @entity5 incurred in high speed motor vehicle accidents. Recognition of such cases is important in the comparison of series and in the evaluation of treatment for @entity5 .

title: Neuropathology of early and late deaths after XXXX .

answer: @entity5


abstract: BACKGROUND: Chronic opioid analgesic use often causes @entity8 ( @entity8 ). This open-label extension study evaluated the safety and efficacy of @entity9 , a @entity7 channel ( @entity10 ) activator, for treatment of @entity8 in @entity0 with chronic @entity2 . METHODS: Adults with @entity8 were enrolled from two 12-week, placebo-controlled, double-blind studies and received @entity9 24   g twice daily for up to 9  months. @entity8 was defined as <  3 spontaneous bowel movements (SBMs)/week during the 2-week baseline period, of which >=   25% were characterized by hard to very hard stool consistency, subjectively incomplete evacuation, and/or moderate or worse straining. Inclusion criteria required consistent treatment with full opioid agonists >=   30  days prior to screening and throughout the study. RESULTS: All 439 @entity0 who received @entity9 were analyzed for safety and efficacy. Overall, 24.6% of @entity0 reported treatment-related adverse events (AEs), most commonly @entity4 (5.0%), @entity3 (4.6%), @entity1 (1.6%), and @entity5 (1.4%). No treatment-related serious AEs were reported. @entity4 and @entity3 each led to study discontinuation in 5 @entity0 (1.1%); 2 cases each of @entity4 and @entity3 were rated as severe. Rescue medication usage decreased from month 1 (33.0%) to month 9 (18.6%). Mean weekly SBM frequency (1.4) was significantly increased from baseline at all months (P  <  0.001, range 4.9 to 5.3). Straining, abdominal bloating, abdominal discomfort, stool consistency, @entity6 severity, and bowel habit regularity were significantly improved from baseline at all months (P  <  0.001). CONCLUSIONS: @entity9 treatment was well tolerated and improved symptoms and signs of @entity8 in this 9-month, open-label study of @entity0 with chronic @entity2 .

title: Long-Term Safety and Efficacy of @entity9 in Opioid-induced XXXX in @entity0 with Chronic Noncancer Pain.

answer: @entity6


abstract: BACKGROUND: Chronic opioid analgesic use often causes @entity8 ( @entity8 ). This open-label extension study evaluated the safety and efficacy of @entity9 , a @entity7 channel ( @entity10 ) activator, for treatment of @entity8 in @entity0 with chronic @entity2 . METHODS: Adults with @entity8 were enrolled from two 12-week, placebo-controlled, double-blind studies and received @entity9 24   g twice daily for up to 9  months. @entity8 was defined as <  3 spontaneous bowel movements (SBMs)/week during the 2-week baseline period, of which >=   25% were characterized by hard to very hard stool consistency, subjectively incomplete evacuation, and/or moderate or worse straining. Inclusion criteria required consistent treatment with full opioid agonists >=   30  days prior to screening and throughout the study. RESULTS: All 439 @entity0 who received @entity9 were analyzed for safety and efficacy. Overall, 24.6% of @entity0 reported treatment-related adverse events (AEs), most commonly @entity4 (5.0%), @entity3 (4.6%), @entity1 (1.6%), and @entity5 (1.4%). No treatment-related serious AEs were reported. @entity4 and @entity3 each led to study discontinuation in 5 @entity0 (1.1%); 2 cases each of @entity4 and @entity3 were rated as severe. Rescue medication usage decreased from month 1 (33.0%) to month 9 (18.6%). Mean weekly SBM frequency (1.4) was significantly increased from baseline at all months (P  <  0.001, range 4.9 to 5.3). Straining, abdominal bloating, abdominal discomfort, stool consistency, @entity6 severity, and bowel habit regularity were significantly improved from baseline at all months (P  <  0.001). CONCLUSIONS: @entity9 treatment was well tolerated and improved symptoms and signs of @entity8 in this 9-month, open-label study of @entity0 with chronic @entity2 .

title: Long-Term Safety and Efficacy of XXXX in Opioid-induced @entity6 in @entity0 with Chronic Noncancer Pain.

answer: @entity9


abstract: BACKGROUND: Chronic opioid analgesic use often causes @entity8 ( @entity8 ). This open-label extension study evaluated the safety and efficacy of @entity9 , a @entity7 channel ( @entity10 ) activator, for treatment of @entity8 in @entity0 with chronic @entity2 . METHODS: Adults with @entity8 were enrolled from two 12-week, placebo-controlled, double-blind studies and received @entity9 24   g twice daily for up to 9  months. @entity8 was defined as <  3 spontaneous bowel movements (SBMs)/week during the 2-week baseline period, of which >=   25% were characterized by hard to very hard stool consistency, subjectively incomplete evacuation, and/or moderate or worse straining. Inclusion criteria required consistent treatment with full opioid agonists >=   30  days prior to screening and throughout the study. RESULTS: All 439 @entity0 who received @entity9 were analyzed for safety and efficacy. Overall, 24.6% of @entity0 reported treatment-related adverse events (AEs), most commonly @entity4 (5.0%), @entity3 (4.6%), @entity1 (1.6%), and @entity5 (1.4%). No treatment-related serious AEs were reported. @entity4 and @entity3 each led to study discontinuation in 5 @entity0 (1.1%); 2 cases each of @entity4 and @entity3 were rated as severe. Rescue medication usage decreased from month 1 (33.0%) to month 9 (18.6%). Mean weekly SBM frequency (1.4) was significantly increased from baseline at all months (P  <  0.001, range 4.9 to 5.3). Straining, abdominal bloating, abdominal discomfort, stool consistency, @entity6 severity, and bowel habit regularity were significantly improved from baseline at all months (P  <  0.001). CONCLUSIONS: @entity9 treatment was well tolerated and improved symptoms and signs of @entity8 in this 9-month, open-label study of @entity0 with chronic @entity2 .

title: Long-Term Safety and Efficacy of @entity9 in Opioid-induced @entity6 in XXXX with Chronic Noncancer Pain.

answer: @entity0


abstract: OBJECTIVE: To examine the relationship between dietary cruciferous vegetable intake and selected @entity2 biomarkers for histone acetylation (H3K9ac, H3K18ac, @entity6 and @entity8 ), proliferation (Ki-67) and cell-cycle regulation ( @entity5 ) from breast tissue. DESIGN: The study used baseline data of @entity1 recruited to participate in a clinical trial of @entity7 supplement. Dietary cruciferous vegetable intake was collected through a validated Arizona Cruciferous Vegetable Intake Questionnaire. Breast tissue was obtained from biopsy samples. Spearman correlations were calculated between intake of specific cruciferous vegetables and biomarkers. Tissue biomarkers were log2-transformed to obtain approximate normality. Linear regression analyses were conducted to examine associations between cruciferous vegetable intake and biomarkers adjusting for age and use of non-steroidal anti-inflammatory drugs. False discovery rate (FDR) was used to account for multiple comparisons. SETTING: Clinical trial baseline. SUBJECTS: Fifty-four @entity1 who had abnormal mammogram findings and were scheduled for breast biopsy. RESULTS: Mean intake of total cruciferous vegetables from all food sources was 81  7 (sd 57  3) g/d. Mean urinary total @entity7 metabolites was 0  08 (sd 0  07)   m/mm @entity4 . Total cruciferous vegetable intake was inversely associated with Ki-67 protein expression in @entity0 in situ (DCIS) tissue (b=-0  004; se=0  001; FDR q value=0  03), but not in benign or @entity3 ( @entity3 ) tissue. No association was found for other biomarkers measured ( @entity6 , @entity8 , H3K9, H3K18 and @entity5 ) in all tissues examined (benign, DCIS and @entity3 ). CONCLUSIONS: The present study sought to provide additional evidence for the potential role of @entity7 in histone acetylation and cell proliferation. Here, we report that total cruciferous vegetable intake is associated with decreased cell proliferation in breast DCIS tissue.

title: Associations between cruciferous vegetable intake and selected biomarkers among XXXX scheduled for breast biopsies.

answer: @entity1


abstract: OBJECT @entity4 ( @entity4 ) are uncommon but bear a significant risk of @entity1 . High-resolution MRI is the standard technique for characterizing @entity4 . However, planning the appropriate extent of resection and subsequent reconstructive strategies is highly dependent on the intraoperative findings because preoperative MRI evaluation can be insufficient. Diffusion tensor tractography (DTT) represents a recently developed advanced MRI technique that reveals the microstructure of tissues based on monitoring the random movement of water molecules. DTT has the potential to provide diagnostic insights beyond conventional MRI techniques due to its mapping of specific fibrillar nerve structures. Here, DTT was applied to evaluate @entity4 and to examine the usefulness of this method for the correct delineation of @entity1 and healthy nerve tissue and the value of this information in the preoperative planning of surgical interventions. METHODS In this prospective study, @entity0 with the clinical symptoms of a PNST were investigated using DTT 3-Tesla MRI scans. Image data processing and tractography were performed using the FACT (fiber assessment by continuous tracking) algorithm and multiple-regions-of-interest approach. The surgical findings were then compared with the results of the DTT MRI scans. @entity2 and the correlation with the intraoperative findings were graded. RESULTS In a 21-month period, 12 @entity0 with @entity4 were investigated (7 female and 5 male @entity0 with a mean age of 46.2    19.2 years). All @entity0 underwent surgical @entity1 . @entity3 was the most common benign histopathological finding (n = 7), whereas 2 malignant lesions were detected. In 10 of 12 @entity0 , good preoperative nerve fascicle visualization was achieved using DTT scans. In 9 of 10 @entity0 with good preoperative fascicle visualization, good intraoperative correlation between the DTT scans and surgical anatomy was found. CONCLUSIONS DTT properly visualizes the peripheral nerve fascicles and their correct anatomical relation to PNST. DTT represents a promising new method for the preinterventional planning of nerve @entity1 resection.

title: Diffusion tensor tractography for the surgical management of XXXX .

answer: @entity4


abstract: BACKGROUND: @entity7 is the most common traffic-related injury affecting thousands of @entity0 every year. Conservative treatments have not proven effective in preventing persistent symptoms and disability after @entity7 . Early established @entity2 behaviours within the first weeks after the injury may explain part of the transition from acute to chronic @entity1 ( @entity1 ). Hence, early targeting of psychological risk factors such as @entity2 catastrophizing, fear-avoidance-beliefs, @entity3 , and symptoms of @entity6 ( @entity6 ) may be important in preventing the development of chronic @entity1 . Some evidence exists that targeting fear-avoidance beliefs and @entity6 with exposure strategies and value-based actions may prevent development of @entity5 after @entity7 . Yet, the results have to be tested in a randomized controlled trial (RCT). The primary objective of the present study is to test whether a specifically tailored value-based cognitive-behavioural therapy program (V-CBT) is able to prevent the development of @entity5 , @entity2 , and @entity4 if delivered within the first three months after a @entity7 . METHODS/DESIGN: The current study is a two-armed randomized controlled study with a crossover design. Group A is scheduled for V-CBT within one week of randomization and group B with a delayed onset 3  months after randomization. DISCUSSION: If the study detects significant effects of V-CBT as a preventive intervention, the study will provide new insights of preventive treatment for @entity0 with @entity1 and thereby serve as an important step towards preventing the chronic condition. TRIAL REGISTRATION: Current Controlled Trials Registration September 19, 2014: NCT02251028.

title: Value-based cognitive-behavioural therapy for the prevention of chronic XXXX : protocol of a randomized controlled trial.

answer: @entity1


abstract: OBJECTIVE: @entity3 ( @entity3 ) is the most common type of @entity0 @entity1 , with highly aggressive, lethal malignancy and microRNAs have already been proven to be associated with @entity3 . In this study, we sought to determine the expression, the clinical value and its role in @entity3 progression. METHODS: Clinical @entity3 tissues and common cell lines were collected. Real-time PCR was performed to quantify the @entity4 expression. In addition, the association of @entity4 expression with clinical pathological factors and prognosis was statistically analyzed. Furthermore, cell proliferation was measured after @entity4 was overexpressed transiently in cells. RESULTS: We found that @entity4 was significantly decreased in @entity3 as well as cell lines, when compared with their separated controls. Decreased @entity4 expression was associated with sex, @entity2 type and @entity2 size. Functionally, ectopic expression of @entity4 in A549 and H661 cells inhibited cell proliferation. CONCLUSION: Our data indicated that @entity4 is downregulated and correlated with @entity2 progression, which might be a putitive therapeutic target in @entity3 treatment.

title: MicroRNA-498 is downregulated in XXXX and correlates with @entity2 progression.

answer: @entity3


abstract: OBJECTIVE: @entity3 ( @entity3 ) is the most common type of @entity0 @entity1 , with highly aggressive, lethal malignancy and microRNAs have already been proven to be associated with @entity3 . In this study, we sought to determine the expression, the clinical value and its role in @entity3 progression. METHODS: Clinical @entity3 tissues and common cell lines were collected. Real-time PCR was performed to quantify the @entity4 expression. In addition, the association of @entity4 expression with clinical pathological factors and prognosis was statistically analyzed. Furthermore, cell proliferation was measured after @entity4 was overexpressed transiently in cells. RESULTS: We found that @entity4 was significantly decreased in @entity3 as well as cell lines, when compared with their separated controls. Decreased @entity4 expression was associated with sex, @entity2 type and @entity2 size. Functionally, ectopic expression of @entity4 in A549 and H661 cells inhibited cell proliferation. CONCLUSION: Our data indicated that @entity4 is downregulated and correlated with @entity2 progression, which might be a putitive therapeutic target in @entity3 treatment.

title: MicroRNA-498 is downregulated in @entity3 and correlates with XXXX progression.

answer: @entity2


abstract: INTRODUCTION: The aim of this study was to report our results with open transgastric necrosectomy for walled-off @entity2 in acute @entity6 over a period of ten years. METHODS: @entity0 operated at the department from 2003 until 2012 were studied retrospectively. RESULTS: A total of 50 @entity0 had surgery. The median age was 55 years (range: 17-79 years). The presumed aetiologies were: @entity8 (n = 28), @entity3 (n = 8) and other causes (n = 14). The median preoperative stay at hospital was 50 days (range: 2-150 days). Bacterial culture from the @entity2 tissue was positive in 26 @entity0 (52%), negative in 15 @entity0 (30%); and in nine @entity0 , no information on this was available. In all, 22 @entity0 (44%) had one or more incidents (i.e. @entity9 , @entity5 , new abscess, @entity7 or delayed @entity4 ) where additional invasive therapy was needed. Ten @entity0 (20%) died during their admission to our department. In total, 18 (45%) @entity0 developed late complications defined as endocrine and/or exocrine malfunction of the pancreas ( @entity1 (n = 10), exocrine insufficiency (n = 4), both @entity1 (n = 4)). CONCLUSION: Acute @entity6 with walled-off @entity2 has a high mortality rate. Need for additional therapy following necrosectomy was associated with fatal outcome. Endocrine and exocrine insufficiency was often seen at follow-up. FUNDING: none. TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency via Region of Southern Denmark (case no. 13/29319).

title: Ten years of experience with transgastric necrosectomy for walled-off @entity2 in acute XXXX .

answer: @entity6


abstract: INTRODUCTION: The aim of this study was to report our results with open transgastric necrosectomy for walled-off @entity2 in acute @entity6 over a period of ten years. METHODS: @entity0 operated at the department from 2003 until 2012 were studied retrospectively. RESULTS: A total of 50 @entity0 had surgery. The median age was 55 years (range: 17-79 years). The presumed aetiologies were: @entity8 (n = 28), @entity3 (n = 8) and other causes (n = 14). The median preoperative stay at hospital was 50 days (range: 2-150 days). Bacterial culture from the @entity2 tissue was positive in 26 @entity0 (52%), negative in 15 @entity0 (30%); and in nine @entity0 , no information on this was available. In all, 22 @entity0 (44%) had one or more incidents (i.e. @entity9 , @entity5 , new abscess, @entity7 or delayed @entity4 ) where additional invasive therapy was needed. Ten @entity0 (20%) died during their admission to our department. In total, 18 (45%) @entity0 developed late complications defined as endocrine and/or exocrine malfunction of the pancreas ( @entity1 (n = 10), exocrine insufficiency (n = 4), both @entity1 (n = 4)). CONCLUSION: Acute @entity6 with walled-off @entity2 has a high mortality rate. Need for additional therapy following necrosectomy was associated with fatal outcome. Endocrine and exocrine insufficiency was often seen at follow-up. FUNDING: none. TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency via Region of Southern Denmark (case no. 13/29319).

title: Ten years of experience with transgastric necrosectomy for walled-off XXXX in acute @entity6 .

answer: @entity2


abstract: Atypical cases of heritable @entity4 have been noted that conform clinically and biochemically to anemias of the pyruvatekinase (PK)-deficient type, except for the presence of apparently adequate quantities of erythrocyte-PK activity by the usual assay procedure. Investigations of four such anomalous cases, occurring in two unrelated families, are presented. Erythrocytes contained a kinetically aberrant isozyme of @entity3 kinase (PK(2)). Michaelis constants for the pathologic isozyme relative to @entity5 were over 10-fold greater than control values, but no kinetic abnormality was evident for the second substrate, @entity1 . PK(2) exhibited a pH optimum almost 1 U lower than the wild enzyme form (PK(1)). Significant differences were also evident in the functional stabilities of the isozymes. Leukocytes were unaffected. Family studies revealed paternal heterozygosity for quantitative @entity2 of the usual type. Clinically normal maternal relatives and some siblings demonstrated intermediate deviations in erythrocyte-PK kinetics and reaction characteristics compatible with coexistence of normal PK(1) and kinetically abnormal PK(2). @entity4 in the propositi appeared to require simultaneous inheritance of the gene governing PK(2) production and its presumed allele resulting in quantitative @entity2 . Both @entity0 were traced through three generations, the defective gene in both instances apparently resident on autosomes.A revision of the PK assay technique is suggested, since catalytic inefficiency of PK(2) was manifested only at low substrate concentrations and was therefore undetectable at the relatively high @entity5 levels employed in the conventional assay.

title: An XXXX of erythrocyte @entity3 kinase. Identification of a kinetically aberrant isozyme associated with premature hemolysis.

answer: @entity0


abstract: Atypical cases of heritable @entity4 have been noted that conform clinically and biochemically to anemias of the pyruvatekinase (PK)-deficient type, except for the presence of apparently adequate quantities of erythrocyte-PK activity by the usual assay procedure. Investigations of four such anomalous cases, occurring in two unrelated families, are presented. Erythrocytes contained a kinetically aberrant isozyme of @entity3 kinase (PK(2)). Michaelis constants for the pathologic isozyme relative to @entity5 were over 10-fold greater than control values, but no kinetic abnormality was evident for the second substrate, @entity1 . PK(2) exhibited a pH optimum almost 1 U lower than the wild enzyme form (PK(1)). Significant differences were also evident in the functional stabilities of the isozymes. Leukocytes were unaffected. Family studies revealed paternal heterozygosity for quantitative @entity2 of the usual type. Clinically normal maternal relatives and some siblings demonstrated intermediate deviations in erythrocyte-PK kinetics and reaction characteristics compatible with coexistence of normal PK(1) and kinetically abnormal PK(2). @entity4 in the propositi appeared to require simultaneous inheritance of the gene governing PK(2) production and its presumed allele resulting in quantitative @entity2 . Both @entity0 were traced through three generations, the defective gene in both instances apparently resident on autosomes.A revision of the PK assay technique is suggested, since catalytic inefficiency of PK(2) was manifested only at low substrate concentrations and was therefore undetectable at the relatively high @entity5 levels employed in the conventional assay.

title: An @entity0 of erythrocyte XXXX kinase. Identification of a kinetically aberrant isozyme associated with premature hemolysis.

answer: @entity3


abstract: @entity2 continue to cause considerable losses among dairy @entity0 in the Netherlands. A considerable part is due to @entity1 , previously quantified at Dfl. 125.-per average @entity0 present, which would account to as much as Dfl. 165.-at current production and price-levels. A major part is caused by milk which was not produced. Under the present market and price policy, the same price is paid for each kg of milk, whatever the quantity produced per farm. In this situation, the milk which is not produced is therefore valued at the current price of Dfl. 0.60 per kg. If a quota-system were to be imposed per farm, an additional kg of milk would have to be valued at a lower price. Yet the losses due to @entity1 and conversely, the profits of reducing the disease, remain almost unchanged in this situation. Instead of increased production per farm, there is a possibility of achieving a similar production per farm with less @entity0 and at reduced cost. Calculations show that when a quota-system is imposed on each farm, the economic profitableness of improved health continues to be important.

title: [The economic significance of XXXX in current and altered agricultural policies (author's transl)].

answer: @entity1


abstract: Although much is known of the causes and prevention of @entity5 , this continues to be a common vice in @entity4 . The animals seek diversion by chewing on the tails of their fellows as they feel uncomfortable. This may result in @entity1 of the tail. Prevention should be directed towards improvement of the conditions which cause the animal to feel uncomfortable. As this will often not be possible or only in part, efforts are made to prevent @entity5 by docking the tails. When tail-docking is performed according to the rule in one- to three-day-old animals, @entity5 obviously will no longer be possible. However, this does not mean removing the causes of @entity5 . This procedure is therefore undesirable from the point of view of welfare of the animals. Inflammation of the tail may result in @entity0 to the spinal column and/or lungs. This is frequently associated with @entity2 . Moreover, the resulting @entity3 formation will be highly objectionable from the point of view of hygiene.

title: [Tail-biting in XXXX . Causes, effects and prevention].

answer: @entity4


abstract: The number of strains of @entity0 studied was 413, and these were obtained from all clinical materials with the exception of fecal specimens. @entity2 was fermented by 37 strains (P. inconstans, 29%; @entity15 , 16%; @entity12 , 4.2%; @entity13 , 3.6%; and @entity14 , 0%) of which 33 were from the genitourinary system. These 33 strains constituted 12.7% of the 260 strains isolated from this source. Biochemically, @entity12 was the least variable, and @entity15 was the most variable of the five species of @entity0 tested. P. inconstans and @entity15 resembled each other more closely than any of the other species of @entity0 . Comparison of results obtained in the Memphis area with those found in other locations showed that biochemical characteristics varied most with the substances @entity5 , @entity16 , @entity9 , @entity11 , and @entity6 . In contrast to earlier reports from Israel and England, none of the strains of P. inconstans in the present study was able to attack @entity3 . All five species of @entity0 tested (by the disc method) were highly susceptible to @entity4 mandelate. @entity12 , @entity13 , and @entity14 were also highly susceptible to @entity10 . All strains of @entity12 were susceptible to @entity1 . P. inconstans was the most resistant species of @entity0 . Of the other 356 urease-positive strains tested, 79% were susceptible to @entity7 , whereas only 3.8% of the 56 urease-negative strains (P. inconstans) were susceptible. When tested with @entity8 , 61% of urease-positive strains were susceptible and 1.8% of the urease-negative strains were susceptible. Of 36 @entity2 -positive strains, 33.8% were susceptible to @entity7 , whereas 72.8% of all @entity2 -negative strains were susceptible. Again, of the @entity2 -positive strains, 17% were susceptible to @entity8 , whereas 56.3% of all @entity2 -negative strains were susceptible.

title: Metabolic variations of XXXX in the Memphis area and other geographical areas.

answer: @entity0


abstract: One hundred and forty-eight @entity0 over the age of 12 years seen from July 1972 through December 1980 were accepted for this review of @entity2 ( @entity2 ). The diagnosis was based on a typical clinical presentation, and renal biopsy findings. @entity2 forms 43.5 per cent of our @entity0 with @entity7 . The @entity0 were predominantly young adults (82 per cent) and the onset of @entity6 ( @entity6 ) occurred below the age of 30 years. Most @entity0 had severe @entity1 and hypoalbuminaemia. Few @entity0 recovered spontaneously. One hundred and thirty @entity0 were given long-term alternate-day @entity3 (LASt) therapy. Four had @entity5 alone, 21 @entity0 had @entity5 after a trial of LASt. Eighty-four @entity0 (62.7 per cent) were initial responders: 17 of these after @entity5 , 26 (19.4 per cent) were initial non-responders: five @entity5 , 19 were late responders. Nine @entity0 were partial responders, six were non-responders and one went into @entity4 . Forty-one @entity0 defaulted, emigrated or were seen only locally at the time of study. Ninety-nine @entity0 were followed for three to 102 months (mean 23 . 3 months). Thirty-seven @entity0 were followed for 36 to 102 months. Relapses were infrequent but occurred as late as 60 months.

title: Minimal XXXX in Malaysian adults and use of alternate day @entity3 therapy.

answer: @entity2


abstract: One hundred and forty-eight @entity0 over the age of 12 years seen from July 1972 through December 1980 were accepted for this review of @entity2 ( @entity2 ). The diagnosis was based on a typical clinical presentation, and renal biopsy findings. @entity2 forms 43.5 per cent of our @entity0 with @entity7 . The @entity0 were predominantly young adults (82 per cent) and the onset of @entity6 ( @entity6 ) occurred below the age of 30 years. Most @entity0 had severe @entity1 and hypoalbuminaemia. Few @entity0 recovered spontaneously. One hundred and thirty @entity0 were given long-term alternate-day @entity3 (LASt) therapy. Four had @entity5 alone, 21 @entity0 had @entity5 after a trial of LASt. Eighty-four @entity0 (62.7 per cent) were initial responders: 17 of these after @entity5 , 26 (19.4 per cent) were initial non-responders: five @entity5 , 19 were late responders. Nine @entity0 were partial responders, six were non-responders and one went into @entity4 . Forty-one @entity0 defaulted, emigrated or were seen only locally at the time of study. Ninety-nine @entity0 were followed for three to 102 months (mean 23 . 3 months). Thirty-seven @entity0 were followed for 36 to 102 months. Relapses were infrequent but occurred as late as 60 months.

title: Minimal @entity2 in Malaysian adults and use of alternate day XXXX therapy.

answer: @entity3


abstract: In 103 @entity0 with @entity2 without associated infections the prophylactic usefulness of antibiotics was assessed clinically. In 30 @entity0 (group I) and 27 @entity0 (group II) @entity6 was used in daily doses of 2-4 g or @entity3 (Polfa) was given 2.4-4.8 million i.u. during 10 days. In the remaining 46 cases (group III) no antibiotics were given and these @entity0 served as controls. During the first 10 days after @entity2 onset @entity4 complications developed significantly less frequently in controls (in 15 cases, i.e. 33%) than in those receiving antibiotic phophylaxis (40 cases i.e. 70%). The difference between the groups was statistically significant (p less than 0.001). In the second ten-day period no clinical evidence of new infection was observed in any group. It may be supposed in the light of these diseases that administration of @entity7 or @entity6 to @entity0 with @entity2 without carrying out antibiotic sensitivity tests is unnecessary. Nearly exclusively @entity1 and @entity5 appear in the first ten days after @entity2 onset which may suggest acute and gradually levelling-off of the neuroregulation of immunological defense mechanisms.

title: [Prophylactic use of @entity7 and @entity6 in XXXX . I. Clinical observations].

answer: @entity2


abstract: In 103 @entity0 with @entity2 without associated infections the prophylactic usefulness of antibiotics was assessed clinically. In 30 @entity0 (group I) and 27 @entity0 (group II) @entity6 was used in daily doses of 2-4 g or @entity3 (Polfa) was given 2.4-4.8 million i.u. during 10 days. In the remaining 46 cases (group III) no antibiotics were given and these @entity0 served as controls. During the first 10 days after @entity2 onset @entity4 complications developed significantly less frequently in controls (in 15 cases, i.e. 33%) than in those receiving antibiotic phophylaxis (40 cases i.e. 70%). The difference between the groups was statistically significant (p less than 0.001). In the second ten-day period no clinical evidence of new infection was observed in any group. It may be supposed in the light of these diseases that administration of @entity7 or @entity6 to @entity0 with @entity2 without carrying out antibiotic sensitivity tests is unnecessary. Nearly exclusively @entity1 and @entity5 appear in the first ten days after @entity2 onset which may suggest acute and gradually levelling-off of the neuroregulation of immunological defense mechanisms.

title: [Prophylactic use of @entity7 and XXXX in @entity2 . I. Clinical observations].

answer: @entity6


abstract: In 103 @entity0 with @entity2 without associated infections the prophylactic usefulness of antibiotics was assessed clinically. In 30 @entity0 (group I) and 27 @entity0 (group II) @entity6 was used in daily doses of 2-4 g or @entity3 (Polfa) was given 2.4-4.8 million i.u. during 10 days. In the remaining 46 cases (group III) no antibiotics were given and these @entity0 served as controls. During the first 10 days after @entity2 onset @entity4 complications developed significantly less frequently in controls (in 15 cases, i.e. 33%) than in those receiving antibiotic phophylaxis (40 cases i.e. 70%). The difference between the groups was statistically significant (p less than 0.001). In the second ten-day period no clinical evidence of new infection was observed in any group. It may be supposed in the light of these diseases that administration of @entity7 or @entity6 to @entity0 with @entity2 without carrying out antibiotic sensitivity tests is unnecessary. Nearly exclusively @entity1 and @entity5 appear in the first ten days after @entity2 onset which may suggest acute and gradually levelling-off of the neuroregulation of immunological defense mechanisms.

title: [Prophylactic use of XXXX and @entity6 in @entity2 . I. Clinical observations].

answer: @entity7


abstract: The presence of @entity3 receptors in @entity0 tissue has been reported to correlate with improved prognosis in @entity1 after mastectomy. The prognostic value (if any) of the presence or absence of @entity3 receptors (ER) in malignant breast tissue was evaluated 104 @entity1 who were treated for primary @entity0 , whose pathology was re-examined, and whose records were subjected to multifactorial analysis. Sixty @entity1 were ER positive, and 44 were ER negative, and a total of 94 who had curative resections were available for follow-up (mean follow-up time 20 months). The presence of @entity3 receptors showed significant positive correlations with @entity4 , and a variant of infiltrating duct @entity2 that is prevalent in the elderly and characterized by the presence of cells showing granular eosinophilic cytoplasm. Of 26 cases identified as infiltrating duct @entity2 showing granular eosinophilic cytoplasm, 22 were ER positive, one was ER negative, and three had borderline values. There was no significant difference between the groups with regard to family history of @entity0 or hysterectomy. A striking observation was noted in the ER positive group in which there were seven cases of second primary @entity0 , whereas no such cases occurred in the ER negative @entity1 (p=0.05). There was a higher percentage of nodal metastases in the @entity1 who were ER positive compared with those who were ER negative; 27 of 53 (51%) of the ER positive @entity1 has positive nodes compared with four of 40 (32%) who were ER negative, p = 0.08. There was no significant correlation of disease free survival nor time to recurrence in either the overall group nor according to stage. In @entity1 whose @entity2 had been reviewed and graded, there was no prognostic relationship of ER status in high grade @entity2 , but in @entity1 with low-grade @entity2 , improved disease-free survival was demonstrated in @entity1 who were ER negative. Although the @entity3 receptor assay is a highly useful @entity2 marker and guide for therapy of advanced @entity0 , its relationship to the prognostic variables of primary @entity0 is complex and controversial and merits continued study.

title: Evaluation of the pathologic and prognostic correlates of XXXX receptors in primary @entity0 .

answer: @entity3


abstract: The presence of @entity3 receptors in @entity0 tissue has been reported to correlate with improved prognosis in @entity1 after mastectomy. The prognostic value (if any) of the presence or absence of @entity3 receptors (ER) in malignant breast tissue was evaluated 104 @entity1 who were treated for primary @entity0 , whose pathology was re-examined, and whose records were subjected to multifactorial analysis. Sixty @entity1 were ER positive, and 44 were ER negative, and a total of 94 who had curative resections were available for follow-up (mean follow-up time 20 months). The presence of @entity3 receptors showed significant positive correlations with @entity4 , and a variant of infiltrating duct @entity2 that is prevalent in the elderly and characterized by the presence of cells showing granular eosinophilic cytoplasm. Of 26 cases identified as infiltrating duct @entity2 showing granular eosinophilic cytoplasm, 22 were ER positive, one was ER negative, and three had borderline values. There was no significant difference between the groups with regard to family history of @entity0 or hysterectomy. A striking observation was noted in the ER positive group in which there were seven cases of second primary @entity0 , whereas no such cases occurred in the ER negative @entity1 (p=0.05). There was a higher percentage of nodal metastases in the @entity1 who were ER positive compared with those who were ER negative; 27 of 53 (51%) of the ER positive @entity1 has positive nodes compared with four of 40 (32%) who were ER negative, p = 0.08. There was no significant correlation of disease free survival nor time to recurrence in either the overall group nor according to stage. In @entity1 whose @entity2 had been reviewed and graded, there was no prognostic relationship of ER status in high grade @entity2 , but in @entity1 with low-grade @entity2 , improved disease-free survival was demonstrated in @entity1 who were ER negative. Although the @entity3 receptor assay is a highly useful @entity2 marker and guide for therapy of advanced @entity0 , its relationship to the prognostic variables of primary @entity0 is complex and controversial and merits continued study.

title: Evaluation of the pathologic and prognostic correlates of @entity3 receptors in primary XXXX .

answer: @entity0


abstract: Saphenous vein (SV), @entity5 ( @entity5 ), and umbilical vein (UV) grafts placed in the femoropopliteal or tibial areas for @entity3 were compared for the years between 1975 and 1982. In proximal v distal popliteal replacement, the early failure rate differed only in PTFE grafts to relieve @entity1 , with below-knee failure being worse. In all femoropopliteal grafts for @entity4 , the SV were better than the UV grafts. When done for @entity1 , the SV were better than the UV grafts. When done for @entity1 , the SV were better than the PTFE grafts. By life-table analysis, SV grafts done for @entity4 or for @entity1 were superior to PTFE grafts. The UV grafts also were better than PTFE grafts. Arteriography showed marked @entity2 in a UV graft in the common femoral to popliteal to anterior tibial area at 50 months. In a second @entity0 , mild @entity2 was seen. The UV graft is acceptable when SV is not available. The PTFE graft across the knee gives poor results but above the knee is comparable with UV grafts.

title: Revascularization of the femoropopliteal arteries using saphenous vein, XXXX , and umbilical vein grafts. Five- and six-year results.

answer: @entity5


abstract: During treatment with @entity5 at the dose of 1 g per day, the mean reduction in low density lipoprotein (LDL) @entity1 concentration was 11.2% in polygenic hypercholesterolaemia (n = 9) and 9.4% in heterozygous @entity4 (n = 6). However, there was marked heterogeneity of response: in seven of the @entity0 with polygenic hypercholesterolaemia who had in common moderate elevation of LDL @entity1 (5.3-6.4 mmol/1), the reduction ranged from 13 to 40% (mean, 23%). In two of this group the change in LDL concentration was associated with a decrease in LDL apolipoprotein B synthetic rate. Of the @entity0 with @entity4 one showed a 33% reduction in LDL @entity1 , and one a 13% reduction. Total high density lipoprotein (HDL) @entity1 concentration tended to decrease during treatment. This reflected a reduction of the @entity1 concentration in the @entity7 subclass; @entity6 @entity1 remaining unchanged. Plasma @entity3 and very low density lipoprotein @entity1 were unaffected by @entity5 . The drug was well tolerated with only one @entity0 complaining of severe @entity2 , and two of mild and transient @entity2 . No clinically significant changes occurred in serial resting electrocardiograms. Thus, @entity5 appears to be a useful drug for the treatment of most @entity0 with polygenic hypercholesterolaemia, and of some @entity0 with heterozygous @entity4 .

title: The effects of XXXX on plasma lipoproteins in @entity4 .

answer: @entity5


abstract: During treatment with @entity5 at the dose of 1 g per day, the mean reduction in low density lipoprotein (LDL) @entity1 concentration was 11.2% in polygenic hypercholesterolaemia (n = 9) and 9.4% in heterozygous @entity4 (n = 6). However, there was marked heterogeneity of response: in seven of the @entity0 with polygenic hypercholesterolaemia who had in common moderate elevation of LDL @entity1 (5.3-6.4 mmol/1), the reduction ranged from 13 to 40% (mean, 23%). In two of this group the change in LDL concentration was associated with a decrease in LDL apolipoprotein B synthetic rate. Of the @entity0 with @entity4 one showed a 33% reduction in LDL @entity1 , and one a 13% reduction. Total high density lipoprotein (HDL) @entity1 concentration tended to decrease during treatment. This reflected a reduction of the @entity1 concentration in the @entity7 subclass; @entity6 @entity1 remaining unchanged. Plasma @entity3 and very low density lipoprotein @entity1 were unaffected by @entity5 . The drug was well tolerated with only one @entity0 complaining of severe @entity2 , and two of mild and transient @entity2 . No clinically significant changes occurred in serial resting electrocardiograms. Thus, @entity5 appears to be a useful drug for the treatment of most @entity0 with polygenic hypercholesterolaemia, and of some @entity0 with heterozygous @entity4 .

title: The effects of @entity5 on plasma lipoproteins in XXXX .

answer: @entity4


abstract: I propose an analogy between @entity6 of the inner ear and those of other organs like brain, @entity4 in which functional and organic alteration can be objectively demonstrated. Symptomatic disturbances of inner ear circulation are monoform in its clinical appearance and the term of 'otangina' is proposed for the functional result. Three types of vascular distribution are discussed for the different regulatory entities, (I) the proximal cerebral vascular type, (II) the predistal innervated regulatory type and the (III) capillary regulatory type. The formal etiology of @entity5 is is developed on the base of @entity6 , i.e. @entity9 , functional alterations, i.e. @entity1 , and finally change in the microcirculation by alterations of the rheology of the blood. @entity2 is portrayed as a main example for cardiovascular risk factors with respect to @entity5 but @entity0 , cigarette smoking and other @entity3 leading to vascular disturbances have to be considered. From these considerations I have developed a basic program for the diagnosis of vascular metabolic risk factors which should be realized before any treatment is advocated. I have critically evaluated the benefit and possible hazardous effects of so called 'vasoactive' and 'cephalotropic' drugs. For most inner ear circulatory disease such therapy is contraindicated. The models of drug treatment of acute @entity8 and the chronic or persistent inner @entity7 should be evaluated in prospective studies.

title: [Therapeutic considerations in XXXX of the inner ear].

answer: @entity6


abstract: Rosette strain gauges were applied to the @entity1 radius and tibia. Three sites were examined on each bone on separate occasions (proximal metaphysis, middiaphysis, and distal metaphysis). At each site, 4 rosette gauges were applied around the bone (ie, cranial, caudal, medial, and lateral). Strain recordings were made while walking the @entity1 with and without a full-limb plaster cast. The principal @entity2 of tensile strain was on the craniolateral aspect of the radius. Distally, on the radius, the largest strains were torsional. The cast changed the principal @entity2 of tensile strain on the radius from the craniolateral surface to the caudal surface. The principal tensile strain of the tibia was just to the lateral side of cranial in the proximal and diaphyseal regions. Distally, the principal @entity2 of tensile strain was craniolateral; however, the largest strains measured here were torsional. The cast changed the principal @entity2 of tensile strain on the distal metaphysis of the tibia, but it did not reduce the magnitude of the strains measured. Casts may not aid stabilization of radial or @entity0 repaired with internal fixation and may in fact place additional stress on the @entity0 site.

title: Multidirectional in vivo strain analysis of the XXXX radius and tibia during dynamic loading with and without a cast.

answer: @entity1


abstract: 1. The contents of high-energy @entity6 at rest have been measured in skeletal muscles with different fibre-type composition from @entity1 , @entity2 and @entity0 . All muscles studied biochemically have been characterized histochemically. 2. Fast-twitch muscles had a higher @entity3 / @entity4 ratio than slow-twitch muscles and, with the exception of the tongue in the @entity1 , higher contents of @entity3 and @entity5 . 3. There was an inverse relationship between the content of @entity5 and the stainability for @entity8 dehydrogenase, which is a marker enzyme for oxidative capacity. 4. The biochemical and histochemical data are discussed in relation to known morphological and functional properties of the different muscle-fibre types. It is concluded that fast-twitch fibres have a high @entity3 / @entity4 ratio favouring a fast acceleration of energy production. The content of @entity5 seems to be related to the glycolytic capacity but not to the contraction time. In addition to being an immediate energy source, @entity5 functions as a buffer against @entity7 .

title: The contents of high-energy @entity6 in different fibre types in skeletal muscles from XXXX , @entity2 and @entity0 .

answer: @entity1


abstract: 1. The contents of high-energy @entity6 at rest have been measured in skeletal muscles with different fibre-type composition from @entity1 , @entity2 and @entity0 . All muscles studied biochemically have been characterized histochemically. 2. Fast-twitch muscles had a higher @entity3 / @entity4 ratio than slow-twitch muscles and, with the exception of the tongue in the @entity1 , higher contents of @entity3 and @entity5 . 3. There was an inverse relationship between the content of @entity5 and the stainability for @entity8 dehydrogenase, which is a marker enzyme for oxidative capacity. 4. The biochemical and histochemical data are discussed in relation to known morphological and functional properties of the different muscle-fibre types. It is concluded that fast-twitch fibres have a high @entity3 / @entity4 ratio favouring a fast acceleration of energy production. The content of @entity5 seems to be related to the glycolytic capacity but not to the contraction time. In addition to being an immediate energy source, @entity5 functions as a buffer against @entity7 .

title: The contents of high-energy XXXX in different fibre types in skeletal muscles from @entity1 , @entity2 and @entity0 .

answer: @entity6


abstract: 1. The contents of high-energy @entity6 at rest have been measured in skeletal muscles with different fibre-type composition from @entity1 , @entity2 and @entity0 . All muscles studied biochemically have been characterized histochemically. 2. Fast-twitch muscles had a higher @entity3 / @entity4 ratio than slow-twitch muscles and, with the exception of the tongue in the @entity1 , higher contents of @entity3 and @entity5 . 3. There was an inverse relationship between the content of @entity5 and the stainability for @entity8 dehydrogenase, which is a marker enzyme for oxidative capacity. 4. The biochemical and histochemical data are discussed in relation to known morphological and functional properties of the different muscle-fibre types. It is concluded that fast-twitch fibres have a high @entity3 / @entity4 ratio favouring a fast acceleration of energy production. The content of @entity5 seems to be related to the glycolytic capacity but not to the contraction time. In addition to being an immediate energy source, @entity5 functions as a buffer against @entity7 .

title: The contents of high-energy @entity6 in different fibre types in skeletal muscles from @entity1 , XXXX and @entity0 .

answer: @entity2


abstract: 1. The contents of high-energy @entity6 at rest have been measured in skeletal muscles with different fibre-type composition from @entity1 , @entity2 and @entity0 . All muscles studied biochemically have been characterized histochemically. 2. Fast-twitch muscles had a higher @entity3 / @entity4 ratio than slow-twitch muscles and, with the exception of the tongue in the @entity1 , higher contents of @entity3 and @entity5 . 3. There was an inverse relationship between the content of @entity5 and the stainability for @entity8 dehydrogenase, which is a marker enzyme for oxidative capacity. 4. The biochemical and histochemical data are discussed in relation to known morphological and functional properties of the different muscle-fibre types. It is concluded that fast-twitch fibres have a high @entity3 / @entity4 ratio favouring a fast acceleration of energy production. The content of @entity5 seems to be related to the glycolytic capacity but not to the contraction time. In addition to being an immediate energy source, @entity5 functions as a buffer against @entity7 .

title: The contents of high-energy @entity6 in different fibre types in skeletal muscles from @entity1 , @entity2 and XXXX .

answer: @entity0


abstract: OBJECTIVE: Our objective was to compare maternal and neonatal outcomes in @entity0 with @entity11 ( @entity11 ) delivered prior to 34(  /7) weeks upon confirmation of fetal lung maturity (FLM) to those managed expectantly until 34(  /7) weeks. METHODS: We performed a retrospective cohort study of non-anomalous singleton gestations with @entity11 occurring after 24 weeks delivered between 32(  /7) and 34(  /7) weeks from 2004 to 2012. @entity0 delivered upon documented FLM (+FLM) - defined as the presence of @entity7 (PG) at 32(  /7)-33(6/7) weeks if amniotic fluid was obtainable vaginally - were compared with @entity0 delivered without documented FLM between 32(  /7) and 34(  /7) weeks (expectant). Primary outcomes included @entity1 (clinically diagnosed @entity10 or @entity9 ), @entity8 and a composite of neonatal morbidities (including but not limited to mechanical ventilation, @entity3 , @entity6 , @entity2 and @entity4 ). Statistical analysis was performed using Student's t-test for continuous variables and Chi-square or Fisher's exact test for categorical data. Covariates were analyzed via multivariate logistic regression and adjusted odds ratios were calculated. RESULTS: Of 237 PPROMs delivered at 32(  /7)-34(  /7) weeks, 74 were intentionally delivered for +FLM and 163 were expectantly managed. No cord prolapse or @entity5 was observed. @entity1 ( @entity9 or @entity10 ) was lower in the +FLM group (aOR 0.33 95% CI 0.12-0.88). Overall, there was no difference in composite neonatal morbidity did not differ between the two groups (aOR 1.36 95% CI 0.53-3.54). CONCLUSIONS: In @entity0 with @entity11 , delivery after confirmation of FLM at 32(  /7)-33(6/7) weeks compared with expectant management until 34(  /7) weeks may prevent @entity1 without increasing neonatal morbidity.

title: Preterm premature rupture of membranes ( XXXX ): outcomes of delivery at 32(  /7) -33(6/7) weeks after confirmed fetal lung maturity (FLM) versus expectant management until 34(  /7) weeks.

answer: @entity11


abstract: BACKGROUND: In 15 % to 25  % of @entity0 , the @entity6 ( @entity6 ) are known to be involved especially with @entity2 lying below the peritoneal reflection. While @entity5 ( @entity5 ) ensures removal of locoregional lymph nodes, it does not address the @entity6 . @entity6 ( @entity6 ) is being performed in selected scenarios for persistent @entity6 after administration of neoadjuvant chemoradiotherapy (NACTRT). Through our study, we share our initial experience with @entity6 in @entity0 with persistent pelvic nodes after NACTRT in advanced @entity2 . METHODS: From October 2013 to November 2014, eight @entity0 underwent @entity5 with @entity6 after NACTRT. @entity6 was performed when pelvic node @entity1 was suspected on preoperative magnetic resonance imaging (MRI) and persisted following preoperative NACTRT. Clinicopathological and perioperative details were recorded for these eight @entity0 . RESULTS: Out of the 144 @entity0 operated with curative intent for rectal @entity7 , eight (5  %) @entity0 had persistent lateral pelvic nodes following NACTRT. These @entity0 underwent a @entity5 with @entity6 . The median operative time was 240  min, and the median @entity4 was 800  mL. Two out of eight @entity0 showed @entity3 in the lateral pelvic nodes (i.e. 25  %). Of these two @entity0 , one also had @entity3 in the mesorectal nodes, post NACTRT. The median length of hospital stay was 6  days. No genitourinary complications were reported. The median follow up for these eight @entity0 was 13  months (6-16  months). The 1  year disease free survival was 100  % with all @entity0 surviving till date. CONCLUSION: @entity6 can be performed with acceptable perioperative outcomes in carefully selected @entity0 .

title: Preliminary experience with lateral pelvic lymph node dissection in locally advanced XXXX .

answer: @entity2


abstract: PURPOSE: To evaluate the ocular surface change and the inflammatory response in a @entity0 model of short-term exposure @entity2 . METHODS: Short term exposure @entity2 by continuous eyelid opening was induced in New Zealand white @entity0 for up to 4 hours. Ultrasound pachymetry was used to detect central total corneal thickness. In vivo confocal microscopy and impression cytology were performed to evaluate the morphology of ocular surface epithelium and the infiltration of inflammatory cells. Immunohistochemistry for macrophage,neutrophil, @entity4 (+) T cells, and CD8(+) T cells were performed to classify the inflammatory cells. Scanning electron microscopy(SEM) was performed to detect ocular surface change.The concentrations of @entity5 , IL-17, Line and TNF-awere analyzed by multiplex immunobead assay. TUNEL staining was performed to detect cellular apoptosis. RESULTS: Significant decrease ofcentral total cornealthickness were found within the first 5 minutes and remained stable thereafter, while there were no changes of corneal epithelial thickness.No significant change of corneal, limbal and conjunctival epithelial morphology was found by in vivo confocal microscopy except the time dependent increase of superficial cellular defects in the central @entity1 . Impression cytology also demonstrated time dependent increase of sloughing superficial cells of the central @entity1 . Aggregations ofinflammatory cells were found at 1 hour in the limbal epithelium, 2 hours in the perilimbal conjunctival epithelium, and 3 hours in the peripheral corneal epithelium.In eyes receiving exposure for 4 hours, the infiltration of the inflammatory cells can still be detected at 8 hours after closing eyes.Immunohistochemical study demonstrated the cells to be macrophages, neutrophils, @entity4 -T cells and CD-8 T cells.SEM demonstrated time-depending increase of intercellular border and sloughing of superficial epithelial cells in corneal surface. Time dependent increase of @entity5 , IL-17 and @entity6 in tear was found.TUNEL staining revealed some apoptotic cells in the corneal epithelium and superficial stroma at 3 hours after exposure. CONCLUSIONS: Short term exposure @entity2 can cause significant changes to the ocular surface and inflammatory response. @entity3 , aggregation of inflammatory cells, and @entity1 epithelial cell and superficial keratocyte apoptosis were found no less than 4 hours following the insult.

title: Changes of Ocular Surface and the Inflammatory Response in a XXXX Model of Short-Term Exposure Keratopathy.

answer: @entity0


abstract: UNASSIGNED: Measuring brain electrical impedance (rheoencephalography- @entity3 ) is a potential technique for noninvasive, continuous neuro-monitoring. Typically, @entity1 ( @entity1 ), an invasive monitoring modality, is used in brain monitoring. Our hypothesis was that both modalities would reflect cerebrovascular reactivity. In the present study we compared results of @entity3 to results of @entity1 measurement. @entity0 were used under anesthesia ([Formula: see text]; 36 control and 59 @entity4 infusions). @entity3 was measured by two bipolar @entity3 amplifiers; time constants (Tc) were 3 and 0.3 s. The @entity4 injection caused a transient @entity2 (SAP) and a simultaneous increase in @entity1 and @entity3 pulse amplitude. SAP decrease was 25%              14%; @entity1 was 28%              16%; @entity3 pulse amplitude increase was 209%              17% (Tc 3) and 107%              68% (Tc 0.3). @entity1 increase correlated with @entity3 pulse amplitude increase. Area under the receiver operating characteristic curve was 0.9481 for @entity1 - @entity3 time constants 3 and 0.9335 for @entity1 - @entity3 time constants 0.3; both with [Formula: see text]. The fact that both @entity3 and @entity1 reflect cerebrovascular reactivity indicates the usefulness of @entity3 as a potential technique for noninvasive, continuous neuro-monitoring. The Tc of @entity3 amplifier requires optimization for continuous monitoring of pressure reactivity index.

title: Correlation of rheoencephalogram and XXXX : results of a @entity0 study.

answer: @entity1


abstract: UNASSIGNED: Measuring brain electrical impedance (rheoencephalography- @entity3 ) is a potential technique for noninvasive, continuous neuro-monitoring. Typically, @entity1 ( @entity1 ), an invasive monitoring modality, is used in brain monitoring. Our hypothesis was that both modalities would reflect cerebrovascular reactivity. In the present study we compared results of @entity3 to results of @entity1 measurement. @entity0 were used under anesthesia ([Formula: see text]; 36 control and 59 @entity4 infusions). @entity3 was measured by two bipolar @entity3 amplifiers; time constants (Tc) were 3 and 0.3 s. The @entity4 injection caused a transient @entity2 (SAP) and a simultaneous increase in @entity1 and @entity3 pulse amplitude. SAP decrease was 25%              14%; @entity1 was 28%              16%; @entity3 pulse amplitude increase was 209%              17% (Tc 3) and 107%              68% (Tc 0.3). @entity1 increase correlated with @entity3 pulse amplitude increase. Area under the receiver operating characteristic curve was 0.9481 for @entity1 - @entity3 time constants 3 and 0.9335 for @entity1 - @entity3 time constants 0.3; both with [Formula: see text]. The fact that both @entity3 and @entity1 reflect cerebrovascular reactivity indicates the usefulness of @entity3 as a potential technique for noninvasive, continuous neuro-monitoring. The Tc of @entity3 amplifier requires optimization for continuous monitoring of pressure reactivity index.

title: Correlation of rheoencephalogram and @entity1 : results of a XXXX study.

answer: @entity0


abstract: Chronic treatment of @entity3 with levodopa or levodopa/carbidopa is associated with problems that include @entity4 , on-off phenomena, @entity1 , and possible loss of therapeutic efficacy. We studied the effects of a period of transient drug withdrawal (drug holiday) in 16 @entity0 who manifested these complications of chronic levodopa therapy. @entity0 were evaluated daily before, during, and after the period of drug withdrawal. Eleven of the 16 @entity0 exhibited enhanced motor responsiveness after the holiday and required only half of the initial daily dose for improved motor performance. Most levodopa-induced side effects decreased after the holiday. @entity1 was ameliorated in all cases. The frequency of on-off phenomena and @entity5 also diminished. Sensitivity to levodopa-induced @entity4 was not affected by the drug holiday. Because most @entity0 required lower dosage after the holiday, @entity4 were no longer present. These observations suggest that @entity2 @entity0 who suffer complications of chronic levodopa therapy may benefit from a period of drug withdrawal.

title: Drug holiday and management of XXXX .

answer: @entity2


abstract: Streptokinase was infused for 103 +/- 25 hrs. in 27 @entity0 (6 with @entity5 of the leg, 7 with @entity3 of Vv. axillaris and subclavia, 9 with @entity6 , 3 with chronic @entity1 , 2 with @entity3 of the retinal vein). @entity4 studies were performed repeatedly. Anticoagulation (prolongation of thrombin time to 1 1/2-2 1/2 of normal) could be achieved without additional heparin by reduction of streptokinase to doses as low as 20 000 U/h. Reptilase time correlated significantly with thrombin times. Following 24 hrs. of infusion, PTT was less than 50 sec. and Quick test less than 50% of normal in most instances. No correlation was found between PTT or Quick test and factor II, V, VI, X activities during streptokinase infusion. Bleeding was observed in 18 @entity0 . The infusion was stopped because of @entity2 in 3 cases. None of the coagulation tests performed in this study correlated with the incidence of @entity2 . Hemoglobin concentration decreased 2,6 +/- 1,6 gr% and this decrease could no be explained by blood lesses.

title: [Control of XXXX and complications in long-term streptokinase therapy].

answer: @entity4


abstract: Eighty-two @entity0 with advanced @entity1 of the @entity2 have been treated with sequential administration of @entity4 and @entity3 . @entity4 was given orally (50 mg/sq m). @entity3 was given intravenously 24 hours later. Treatment was repeated four times at weekly intervals. This method of administration is based on laboratory evidence, including cell kinetic studies. Forty-three @entity0 were operated on. Those with involved or close surgical margins or with more than one cancerous neck node were also treated with therapeutic postoperative radiation therapy. Twenty-two @entity0 were treated with only radiation therapy. After surgery and/or radiation therapy, @entity0 were randomly selected as to who would receive further chemotherapy or who would be under observation only. Twenty-two @entity0 are still in the early phases of treatment and follow-up, so their conditions could not be evaluated. Early results indicate a 64% response to initial chemotherapy and no increase in operative difficulty, morbidity, or mortality.

title: Triple therapy for advanced XXXX of the @entity2 .

answer: @entity1


abstract: Eighty-two @entity0 with advanced @entity1 of the @entity2 have been treated with sequential administration of @entity4 and @entity3 . @entity4 was given orally (50 mg/sq m). @entity3 was given intravenously 24 hours later. Treatment was repeated four times at weekly intervals. This method of administration is based on laboratory evidence, including cell kinetic studies. Forty-three @entity0 were operated on. Those with involved or close surgical margins or with more than one cancerous neck node were also treated with therapeutic postoperative radiation therapy. Twenty-two @entity0 were treated with only radiation therapy. After surgery and/or radiation therapy, @entity0 were randomly selected as to who would receive further chemotherapy or who would be under observation only. Twenty-two @entity0 are still in the early phases of treatment and follow-up, so their conditions could not be evaluated. Early results indicate a 64% response to initial chemotherapy and no increase in operative difficulty, morbidity, or mortality.

title: Triple therapy for advanced @entity1 of the XXXX .

answer: @entity2


abstract: BACKGROUND: Self-administered questionnaires provide a better alternative to disclose sensitive information in sexual health research. We describe the factors that determine the positive response (initial recruitment) to an initial invitation and subsequent completion of study to a postal questionnaire on @entity2 . METHODS: South Asians (SA) and Europids with and without @entity1 ( @entity3 ) were recruited from GP clinics in UK. @entity0 who returned the properly filled consent form ('recruited-group') were sent the questionnaire and those who returned it were considered as the 'completed-group'. Index of Multiple Deprivation Scores (IMDs) were generated using UK postcodes. We calculated the recruitment rate and completion rate of the recruited and the study-completed groups respectively. RESULTS: Total approached sample was 9100 [ @entity3 : 2914 (32  %), SA: 4563 (50.1  %)]. Recruitment rate was 8.8  % and was higher in Europids and in @entity0 with @entity3 . Mean IMDs for the recruited group was 20.9      11.9, and it was higher among recruited SA compared to Europids (p  <  0.001). Mean IMDs was higher in the recruited group compared to non-recruited (p  <  0.01). All four recruited groups (SA/Europid and @entity3 /non- @entity3 ) had lower IMDs compared to non-recruited. Completion rate was 71.5  % (n 544) (SA: 62.3  %, Europids: 77.4  %; p  <  0.05). CONCLUSION: Recruitment for postal sexual health surveys is positively influenced by presence of investigated disease, older age, being from lesser deprived areas and Europid ethnicity. Furthermore, Europids were more likely to complete survey than South Asians irrespective of disease status.

title: Ethnicity and neighbourhood deprivation determines the response rate in XXXX surveys.

answer: @entity2


abstract: UNASSIGNED: @entity1 is a @entity2 , displaying significant cellular and histological heterogeneity and a complex genetic phenotype. Although multiple studies strongly suggest the presence of @entity0 stem cells in @entity1 , a consensus on their characterization is still missing. We used a combination of functional assays (sphere-forming, Aldefluor, and side-population) for identification of @entity0 stem cell populations in @entity1 cell lines. Expression of stemness-related transcription factors, quiescent nature, in vivo tumorigenicity, and Wnt/ @entity3 activation were evaluated. We show that different @entity0 stem cell populations may co-exist in @entity1 cell lines exhibiting distinct functional properties. @entity1 spheres are slowly-proliferating populations, overexpress @entity5 , and @entity4 stemness-related genes and have enhanced tumorigenic potential. Additionally, spheres show specific activation of Wnt/ @entity3 signaling as evidenced by increased nuclear @entity3 , TCF/LEF activity, and @entity7 expression, in a subset of the cell lines. Aldefluor-positive populations were detected in all @entity1 cell lines and overexpress @entity5 , but not @entity4 . The side-population phenotype is correlated with @entity6 drug-efflux transporter expression. Distinct functional methods seem to identify @entity0 stem cells with dissimilar characteristics. Intrinsic heterogeneity may exist within @entity0 stem cells and can have implications on the design of targeted therapies aiming to eradicate these cells within @entity0 . J. Cell. Physiol. 9999: 1-11, 2015.    2015 Wiley Periodicals, Inc.

title: XXXX Stem Cells Have Active Wnt/ @entity3 and Overexpress @entity5 and @entity4 .

answer: @entity1


abstract: UNASSIGNED: @entity1 is a @entity2 , displaying significant cellular and histological heterogeneity and a complex genetic phenotype. Although multiple studies strongly suggest the presence of @entity0 stem cells in @entity1 , a consensus on their characterization is still missing. We used a combination of functional assays (sphere-forming, Aldefluor, and side-population) for identification of @entity0 stem cell populations in @entity1 cell lines. Expression of stemness-related transcription factors, quiescent nature, in vivo tumorigenicity, and Wnt/ @entity3 activation were evaluated. We show that different @entity0 stem cell populations may co-exist in @entity1 cell lines exhibiting distinct functional properties. @entity1 spheres are slowly-proliferating populations, overexpress @entity5 , and @entity4 stemness-related genes and have enhanced tumorigenic potential. Additionally, spheres show specific activation of Wnt/ @entity3 signaling as evidenced by increased nuclear @entity3 , TCF/LEF activity, and @entity7 expression, in a subset of the cell lines. Aldefluor-positive populations were detected in all @entity1 cell lines and overexpress @entity5 , but not @entity4 . The side-population phenotype is correlated with @entity6 drug-efflux transporter expression. Distinct functional methods seem to identify @entity0 stem cells with dissimilar characteristics. Intrinsic heterogeneity may exist within @entity0 stem cells and can have implications on the design of targeted therapies aiming to eradicate these cells within @entity0 . J. Cell. Physiol. 9999: 1-11, 2015.    2015 Wiley Periodicals, Inc.

title: @entity1 Stem Cells Have Active Wnt/ @entity3 and Overexpress XXXX and @entity4 .

answer: @entity5


abstract: UNASSIGNED: @entity1 is a @entity2 , displaying significant cellular and histological heterogeneity and a complex genetic phenotype. Although multiple studies strongly suggest the presence of @entity0 stem cells in @entity1 , a consensus on their characterization is still missing. We used a combination of functional assays (sphere-forming, Aldefluor, and side-population) for identification of @entity0 stem cell populations in @entity1 cell lines. Expression of stemness-related transcription factors, quiescent nature, in vivo tumorigenicity, and Wnt/ @entity3 activation were evaluated. We show that different @entity0 stem cell populations may co-exist in @entity1 cell lines exhibiting distinct functional properties. @entity1 spheres are slowly-proliferating populations, overexpress @entity5 , and @entity4 stemness-related genes and have enhanced tumorigenic potential. Additionally, spheres show specific activation of Wnt/ @entity3 signaling as evidenced by increased nuclear @entity3 , TCF/LEF activity, and @entity7 expression, in a subset of the cell lines. Aldefluor-positive populations were detected in all @entity1 cell lines and overexpress @entity5 , but not @entity4 . The side-population phenotype is correlated with @entity6 drug-efflux transporter expression. Distinct functional methods seem to identify @entity0 stem cells with dissimilar characteristics. Intrinsic heterogeneity may exist within @entity0 stem cells and can have implications on the design of targeted therapies aiming to eradicate these cells within @entity0 . J. Cell. Physiol. 9999: 1-11, 2015.    2015 Wiley Periodicals, Inc.

title: @entity1 Stem Cells Have Active Wnt/ @entity3 and Overexpress @entity5 and XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity1 is a @entity2 , displaying significant cellular and histological heterogeneity and a complex genetic phenotype. Although multiple studies strongly suggest the presence of @entity0 stem cells in @entity1 , a consensus on their characterization is still missing. We used a combination of functional assays (sphere-forming, Aldefluor, and side-population) for identification of @entity0 stem cell populations in @entity1 cell lines. Expression of stemness-related transcription factors, quiescent nature, in vivo tumorigenicity, and Wnt/ @entity3 activation were evaluated. We show that different @entity0 stem cell populations may co-exist in @entity1 cell lines exhibiting distinct functional properties. @entity1 spheres are slowly-proliferating populations, overexpress @entity5 , and @entity4 stemness-related genes and have enhanced tumorigenic potential. Additionally, spheres show specific activation of Wnt/ @entity3 signaling as evidenced by increased nuclear @entity3 , TCF/LEF activity, and @entity7 expression, in a subset of the cell lines. Aldefluor-positive populations were detected in all @entity1 cell lines and overexpress @entity5 , but not @entity4 . The side-population phenotype is correlated with @entity6 drug-efflux transporter expression. Distinct functional methods seem to identify @entity0 stem cells with dissimilar characteristics. Intrinsic heterogeneity may exist within @entity0 stem cells and can have implications on the design of targeted therapies aiming to eradicate these cells within @entity0 . J. Cell. Physiol. 9999: 1-11, 2015.    2015 Wiley Periodicals, Inc.

title: @entity1 Stem Cells Have Active Wnt/ XXXX and Overexpress @entity5 and @entity4 .

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to evaluate clinicopathologic characteristics, treatment outcome, and reproductive function in @entity0 diagnosed with @entity2 (IT). Our standard chemotherapy regime is currently @entity5 / @entity3 (EP), creating a unique opportunity to evaluate this protocol in ovarian ITs. MATERIALS AND METHODS: This study is a retrospective analysis. Twenty-seven @entity0 older than 18 years with @entity2 stages IA to IIIC were identified and included in this study. @entity0 were treated at 1 institution, Health Sciences Center, @entity0 's Hospital, Winnipeg, Manitoba, Canada, between 1983 and 2013. RESULTS: The median age at diagnosis was 27.0 years (range, 18-36 years). Twenty-two (82%) presented with an International Federation of Gynecology and Obstetrics stage I disease, 3 (11%) had stage II, and 2 @entity0 (7%) had @entity1 . The histologic grade distribution was grade I in 9 @entity0 (33%), grade II in 3 @entity0 (11%), and grade III in 15 @entity0 (56%). Initial management was surgical for all @entity0 : 3 (11%) hysterectomy and bilateral salpingo-oophorectomy, 1 (4%) cystectomy only, and 23 (85%) unilateral salpingo-oophorectomy. Twenty-one @entity0 (78%) received adjuvant therapy. The median follow-up was 60 months (range, 36-72 months). One @entity0 recurred (histological grade III) 6 months after surgery and had a complete clinical response to 4 cycles of EP chemotherapy. Twelve @entity0 reported an attempt to conceive resulting in 10 pregnancies (8 after chemotherapy). CONCLUSIONS: Ovarian IT is a curable disease. Fertility-sparing surgery should be offered. Adjuvant treatment with @entity3 -based chemotherapy, typically with @entity4 , @entity5 , and @entity3 , is still considered the standard in stages greater than stage IA grade I. @entity5 / @entity3 as a primary chemotherapy regime for early- or advanced-stage disease is an effective treatment with minimal adverse effects and high tolerability. This is the first published study examining EP as a primary treatment modality for IT. Further studies are needed to strengthen these findings.

title: Pure Immature XXXX in Adults: Thirty-Year Experience of a Single Tertiary Care Center.

answer: @entity2