abstract: The historic triad of @entity8 , @entity10 , and intolerance to @entity5 and related chemicals, recently designated as @entity6 , is an inflammatory condition of unknown etiology and pathogenesis. The condition is probably acquired, perhaps secondary to a @entity12 , but a hereditary factor may be important in some @entity0 . Most @entity0 with this syndrome are adults, with an occasional case being identified in a teenager or older @entity0 . Although not every @entity0 will have the fully developed syndrome, the typical @entity0 will have all three of the classic features. Many @entity0 with @entity6 also have a marked @entity11 of both bronchial and nasal secretions as well as the circulating blood. Approximately 10 per cent of the @entity0 have @entity3 and/or @entity4 , alone or in combination with @entity1 . The diagnosis usually can be established easily on the basis of the history and physical examination, and only rarely in clinical practice is it necessary to perform a confirmatory @entity5 challenge test. As with all @entity2 , the cornerstone of treatment is environmental control with avoidance of respiratory irritants, @entity5 , and @entity5 -like medications. Management of upper @entity9 requires careful prescription of medication supplemented by judicious selection of surgery. A variety of medications, including bronchodilators and @entity7 , can be used to treat the bronchial symptoms. The results of current research are expected to lead to better understanding followed by further improvements in treatment for @entity0 with @entity6 .

title: XXXX , nasal polyps, and @entity5 sensitivity: @entity6 .

answer: @entity8


abstract: A large subset of individuals with @entity8 ( @entity8 ) develops clinical @entity2 that progresses to @entity6 . Identification of clinically proteinuric @entity0 has limited impact on management of the condition. No treatment strategy has succeeded in permanently arresting the evolution of clinical @entity2 . However, important advances have been made in slowing its progress, and these are reviewed in this study. Treatment of raised blood pressure early in the course of @entity9 has emerged as the most effective therapeutic measure. Susceptible individuals can be detected before persistent @entity7 becomes manifest by screening @entity8 @entity0 for microalbuminuria, which has proved predictive of persistent @entity7 in approximately 80% of cases. Microalbuminuria can be associated with a raised glomerular filtration rate and is often accompanied by subclinical @entity4 . The independent predictive significance of the two latter variables remains to be established in @entity0 . Unfortunately, microalbuminuria is not apparent until 5 yr after stabilization of newly diagnosed @entity1 , suggesting that it is a marker of @entity3 rather than an indicator of susceptibility. However, many therapeutic interventions, ranging from blood @entity5 control to low-protein diet and angiotensin-converting enzyme inhibition, are effective in reducing or even normalizing microalbuminuria. If current controlled trials show that treatment of microalbuminuric @entity0 prevents progression to clinical @entity2 , the diagnostic criteria for @entity9 will require radical revision.

title: Recent advances in understanding mechanisms and natural history of XXXX .

answer: @entity9


abstract: BACKGROUND: One of the goals of co-operative @entity1 nursing and co-operative team meetings is to improve @entity0 ' and significant others' participation and thus, to enhance @entity0 ' resources outside the hospital. The objective of this paper is to describe the different expert interventions that either enabled or prevented @entity0 and his/her significant others participation in co-operative team meetings in acute @entity1 wards. METHODS: The data consisted of 11 videotaped team meetings. The @entity0 were voluntary @entity0 , significant others and experts in health and social care. A narrative approach focused on the storytelling of all members in the meetings. The method of modified dialogue analysis was used to identify the ideas of the stories. FINDINGS: The same topic of discussion was shared in active participation. The experts asked open-ended questions, the @entity0 and his/her significant others' were free to express their viewpoints and the experts' interpretation was based on their stories. The experts presented the reasons for their questions, and the contents of the questions were verbalized. In passive participation, the experts questions were based on their own point of view, and the @entity0 and his significant others merely answered these questions. If the expert opinion appeared too dominating at the co-operative team meeting, the @entity0 's and his/her significant others' participation was in jeopardy. CONCLUSIONS: The physician either dominates the storytelling or gives space for free expressions of various viewpoints during the co-operative team meetings.

title: Storytelling of co-operative team meetings in acute XXXX care.

answer: @entity1


abstract: PURPOSE: @entity0 with @entity7 ( @entity7 ) usually had an initial precipitating @entity2 . However, @entity5 does not develop in all @entity0 who have undergone an early insult. As in @entity0 , the consequences of the @entity6 - @entity8 -induced @entity4 ( @entity4 ) are age dependent, and only a subset of 21-day-old @entity1 will develop @entity5 . Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of @entity1 . METHODS: @entity4 was induced in 21-day-old @entity1 by the injection of @entity6 and @entity8 . T2-weighted images and T2 relaxation-time measurements were used for detection of lesions from 6 h to 4 months after @entity4 . RESULTS: Three populations of @entity1 could be distinguished. The first one had neither MRI anomalies nor modification of the T2 relaxation time, and these @entity1 did not develop @entity5 . In the second one, a hypersignal appeared at the level of the piriform and entorhinal cortices 24 h after @entity4 (increase of 49% of the T2 relaxation time in the piriform cortex) that began to disappear 48-72 h after @entity4 ; @entity5 developed in all these animals. The third population of @entity1 showed a more moderate increase of the T2 relaxation time in cortices (14% in the piriform cortex) that could not be seen on T2-weighted images. @entity5 developed in all these @entity1 . Only in a subpopulation of the 21-day-old @entity1 with @entity5 did @entity3 develop. CONCLUSIONS: These results suggest that the injury of the piriform and entorhinal cortices during @entity4 play a critical role for the installation of the @entity5 networks and the development of @entity5 .

title: Predictive value of @entity2 for the development of @entity7 in 21-day-old @entity1 : an MRI approach using the XXXX - @entity8 model.

answer: @entity6


abstract: PURPOSE: @entity0 with @entity7 ( @entity7 ) usually had an initial precipitating @entity2 . However, @entity5 does not develop in all @entity0 who have undergone an early insult. As in @entity0 , the consequences of the @entity6 - @entity8 -induced @entity4 ( @entity4 ) are age dependent, and only a subset of 21-day-old @entity1 will develop @entity5 . Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of @entity1 . METHODS: @entity4 was induced in 21-day-old @entity1 by the injection of @entity6 and @entity8 . T2-weighted images and T2 relaxation-time measurements were used for detection of lesions from 6 h to 4 months after @entity4 . RESULTS: Three populations of @entity1 could be distinguished. The first one had neither MRI anomalies nor modification of the T2 relaxation time, and these @entity1 did not develop @entity5 . In the second one, a hypersignal appeared at the level of the piriform and entorhinal cortices 24 h after @entity4 (increase of 49% of the T2 relaxation time in the piriform cortex) that began to disappear 48-72 h after @entity4 ; @entity5 developed in all these animals. The third population of @entity1 showed a more moderate increase of the T2 relaxation time in cortices (14% in the piriform cortex) that could not be seen on T2-weighted images. @entity5 developed in all these @entity1 . Only in a subpopulation of the 21-day-old @entity1 with @entity5 did @entity3 develop. CONCLUSIONS: These results suggest that the injury of the piriform and entorhinal cortices during @entity4 play a critical role for the installation of the @entity5 networks and the development of @entity5 .

title: Predictive value of @entity2 for the development of @entity7 in 21-day-old @entity1 : an MRI approach using the @entity6 - XXXX model.

answer: @entity8


abstract: PURPOSE: @entity0 with @entity7 ( @entity7 ) usually had an initial precipitating @entity2 . However, @entity5 does not develop in all @entity0 who have undergone an early insult. As in @entity0 , the consequences of the @entity6 - @entity8 -induced @entity4 ( @entity4 ) are age dependent, and only a subset of 21-day-old @entity1 will develop @entity5 . Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of @entity1 . METHODS: @entity4 was induced in 21-day-old @entity1 by the injection of @entity6 and @entity8 . T2-weighted images and T2 relaxation-time measurements were used for detection of lesions from 6 h to 4 months after @entity4 . RESULTS: Three populations of @entity1 could be distinguished. The first one had neither MRI anomalies nor modification of the T2 relaxation time, and these @entity1 did not develop @entity5 . In the second one, a hypersignal appeared at the level of the piriform and entorhinal cortices 24 h after @entity4 (increase of 49% of the T2 relaxation time in the piriform cortex) that began to disappear 48-72 h after @entity4 ; @entity5 developed in all these animals. The third population of @entity1 showed a more moderate increase of the T2 relaxation time in cortices (14% in the piriform cortex) that could not be seen on T2-weighted images. @entity5 developed in all these @entity1 . Only in a subpopulation of the 21-day-old @entity1 with @entity5 did @entity3 develop. CONCLUSIONS: These results suggest that the injury of the piriform and entorhinal cortices during @entity4 play a critical role for the installation of the @entity5 networks and the development of @entity5 .

title: Predictive value of @entity2 for the development of @entity7 in 21-day-old XXXX : an MRI approach using the @entity6 - @entity8 model.

answer: @entity1


abstract: PURPOSE: @entity0 with @entity7 ( @entity7 ) usually had an initial precipitating @entity2 . However, @entity5 does not develop in all @entity0 who have undergone an early insult. As in @entity0 , the consequences of the @entity6 - @entity8 -induced @entity4 ( @entity4 ) are age dependent, and only a subset of 21-day-old @entity1 will develop @entity5 . Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of @entity1 . METHODS: @entity4 was induced in 21-day-old @entity1 by the injection of @entity6 and @entity8 . T2-weighted images and T2 relaxation-time measurements were used for detection of lesions from 6 h to 4 months after @entity4 . RESULTS: Three populations of @entity1 could be distinguished. The first one had neither MRI anomalies nor modification of the T2 relaxation time, and these @entity1 did not develop @entity5 . In the second one, a hypersignal appeared at the level of the piriform and entorhinal cortices 24 h after @entity4 (increase of 49% of the T2 relaxation time in the piriform cortex) that began to disappear 48-72 h after @entity4 ; @entity5 developed in all these animals. The third population of @entity1 showed a more moderate increase of the T2 relaxation time in cortices (14% in the piriform cortex) that could not be seen on T2-weighted images. @entity5 developed in all these @entity1 . Only in a subpopulation of the 21-day-old @entity1 with @entity5 did @entity3 develop. CONCLUSIONS: These results suggest that the injury of the piriform and entorhinal cortices during @entity4 play a critical role for the installation of the @entity5 networks and the development of @entity5 .

title: Predictive value of XXXX for the development of @entity7 in 21-day-old @entity1 : an MRI approach using the @entity6 - @entity8 model.

answer: @entity2


abstract: PURPOSE: @entity0 with @entity7 ( @entity7 ) usually had an initial precipitating @entity2 . However, @entity5 does not develop in all @entity0 who have undergone an early insult. As in @entity0 , the consequences of the @entity6 - @entity8 -induced @entity4 ( @entity4 ) are age dependent, and only a subset of 21-day-old @entity1 will develop @entity5 . Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of @entity1 . METHODS: @entity4 was induced in 21-day-old @entity1 by the injection of @entity6 and @entity8 . T2-weighted images and T2 relaxation-time measurements were used for detection of lesions from 6 h to 4 months after @entity4 . RESULTS: Three populations of @entity1 could be distinguished. The first one had neither MRI anomalies nor modification of the T2 relaxation time, and these @entity1 did not develop @entity5 . In the second one, a hypersignal appeared at the level of the piriform and entorhinal cortices 24 h after @entity4 (increase of 49% of the T2 relaxation time in the piriform cortex) that began to disappear 48-72 h after @entity4 ; @entity5 developed in all these animals. The third population of @entity1 showed a more moderate increase of the T2 relaxation time in cortices (14% in the piriform cortex) that could not be seen on T2-weighted images. @entity5 developed in all these @entity1 . Only in a subpopulation of the 21-day-old @entity1 with @entity5 did @entity3 develop. CONCLUSIONS: These results suggest that the injury of the piriform and entorhinal cortices during @entity4 play a critical role for the installation of the @entity5 networks and the development of @entity5 .

title: Predictive value of @entity2 for the development of XXXX in 21-day-old @entity1 : an MRI approach using the @entity6 - @entity8 model.

answer: @entity7


abstract: The authors report on six @entity0 in whom an aggressive @entity3 of the wrist and erosion of the adjacent bones has developed after insertion of Silastic implants in the region of the carpus. @entity2 , dislocation or @entity1 of the prosthesis was not present. In surgical revision, the prosthesis shows changes in form and rough surfaces. The synovial membrane is massively thickened and highly inflamed with @entity6 formation; the adjacent bone showed cartilage loss and fragmentations. Light and electron microscopic investigations of the synovial membrane and the bone show giant cells with @entity5 particles. We consider that compression, shearing forces as well as @entity4 are to be considered primarily as causes of @entity7 . Other factors such as age, profession and location hardly play any role. Prostheses which are too large, the presence of osteophytes and structural loosening of the carpal bones are avoidable risks. After removal of the prosthesis and the synovial membrane, there is rapid healing. Subsequent arthrodesis also heals without problems.

title: [ @entity3 of the wrist joint following XXXX replacement of the carpal bones].

answer: @entity5


abstract: The authors report on six @entity0 in whom an aggressive @entity3 of the wrist and erosion of the adjacent bones has developed after insertion of Silastic implants in the region of the carpus. @entity2 , dislocation or @entity1 of the prosthesis was not present. In surgical revision, the prosthesis shows changes in form and rough surfaces. The synovial membrane is massively thickened and highly inflamed with @entity6 formation; the adjacent bone showed cartilage loss and fragmentations. Light and electron microscopic investigations of the synovial membrane and the bone show giant cells with @entity5 particles. We consider that compression, shearing forces as well as @entity4 are to be considered primarily as causes of @entity7 . Other factors such as age, profession and location hardly play any role. Prostheses which are too large, the presence of osteophytes and structural loosening of the carpal bones are avoidable risks. After removal of the prosthesis and the synovial membrane, there is rapid healing. Subsequent arthrodesis also heals without problems.

title: [ XXXX of the wrist joint following @entity5 replacement of the carpal bones].

answer: @entity3


abstract: Previous results suggest that extracellular @entity1 (DA) in the @entity0 cerebral cortex originates from dopaminergic and noradrenergic terminals. To further clarify this issue, dialysate DA, @entity8 ( @entity4 ) and @entity2 (NA) were measured both in the medial prefrontal cortex (mPFC) and in the occipital cortex (OCC), with dense and scarce dopaminergic projections, respectively. Moreover, the effect of the alpha2-adrenoceptor antagonist @entity9 and the D2-receptor antagonist @entity3 on extracellular DA, @entity4 and NA was investigated. Extracellular DA and @entity4 concentrations in the OCC were 43% and 9%, respectively, those in the mPFC. @entity3 (0.1 mg/kg i.p.) increased DA and @entity4 (by 35% and 150%, respectively) in the mPFC, but was ineffective in the OCC. In contrast, @entity9 (1.5 mg/kg i.p.) increased NA, DA and @entity4 , both in the mPFC (by approximately 50%, 60% and 130%, respectively) and the OCC (by approximately 50%, 80% and 200%, respectively). Locally perfused, the DA transporter blocker @entity7 (10 micro m) was ineffective in either cortex, whereas @entity5 ( @entity6 , 100 micro m) markedly increased extracellular NA and DA in both cortices. The weak @entity3 effect on DA efflux was not enhanced after DA- and NA-transporter blockade, whereas after @entity6 , @entity9 markedly increased extracellular NA, and especially DA and @entity4 in both cortices. The results support the hypothesis that most extracellular DA in the cortex is co-released with NA from noradrenergic terminals, such co-release being primarily controlled by alpha2-adrenoceptors.

title: Alpha2-adrenoceptor mediated co-release of @entity1 and XXXX from noradrenergic neurons in the cerebral cortex.

answer: @entity2


abstract: Previous results suggest that extracellular @entity1 (DA) in the @entity0 cerebral cortex originates from dopaminergic and noradrenergic terminals. To further clarify this issue, dialysate DA, @entity8 ( @entity4 ) and @entity2 (NA) were measured both in the medial prefrontal cortex (mPFC) and in the occipital cortex (OCC), with dense and scarce dopaminergic projections, respectively. Moreover, the effect of the alpha2-adrenoceptor antagonist @entity9 and the D2-receptor antagonist @entity3 on extracellular DA, @entity4 and NA was investigated. Extracellular DA and @entity4 concentrations in the OCC were 43% and 9%, respectively, those in the mPFC. @entity3 (0.1 mg/kg i.p.) increased DA and @entity4 (by 35% and 150%, respectively) in the mPFC, but was ineffective in the OCC. In contrast, @entity9 (1.5 mg/kg i.p.) increased NA, DA and @entity4 , both in the mPFC (by approximately 50%, 60% and 130%, respectively) and the OCC (by approximately 50%, 80% and 200%, respectively). Locally perfused, the DA transporter blocker @entity7 (10 micro m) was ineffective in either cortex, whereas @entity5 ( @entity6 , 100 micro m) markedly increased extracellular NA and DA in both cortices. The weak @entity3 effect on DA efflux was not enhanced after DA- and NA-transporter blockade, whereas after @entity6 , @entity9 markedly increased extracellular NA, and especially DA and @entity4 in both cortices. The results support the hypothesis that most extracellular DA in the cortex is co-released with NA from noradrenergic terminals, such co-release being primarily controlled by alpha2-adrenoceptors.

title: Alpha2-adrenoceptor mediated co-release of XXXX and @entity2 from noradrenergic neurons in the cerebral cortex.

answer: @entity1


abstract: OBJECTIVE: To assess the burden (incidence, treatment and complications) of @entity3 ( @entity3 ) and @entity7 media with effusion (OME) in @entity0 younger than 5 years of age from Valencia, Spain. SUBJECT AND METHODS: We performed a retrospective cohort study of 1,399 @entity0 followed-up for the first 5 years of life. Seventeen pediatricians reviewed the medical records of their @entity0 born in 1995 and 1996 and followed-up from birth until the age of 5 years. For each @entity0 , the number of @entity7 episodes, treatment, complications, and surgical interventions was obtained. RESULTS: There were 2,961 episodes of @entity3 in the first 5 years of life (2.23 cases/ @entity0 ). Four hundred seventy-six cases (16.1 %) occurred before 1 year of age and 1,346 between the first and second year of life (45.5 %). By the third year of life, 59.8 % had had at least one episode. In most @entity0 (80.9 %), diagnosis was made in primary care and required a median of 1.81 visits/episode for follow-up. A total of 94.5 % were treated with antibiotics ( @entity1 - @entity4 38.8 %, @entity5 14.3 %, @entity9 8.2 % and @entity1 5.9 %) and 8.5 % required a change of antibiotic therapy. Two hundred seventeen @entity0 (15.2 %) had at least one episode of OME. Twenty-six @entity0 (1.8 %, 95 % CI: 1.2-2.7 %) required insertion of ventilation tubes. Twenty-four @entity0 (1.7 %) had secondary hypoacusis. There was one case of @entity2 and two cases of chronic @entity8 . No cases of @entity6 were recorded. CONCLUSIONS: The incidence of @entity3 in Valencia is 40,014 episodes/100,000 @entity0 younger than 5 years/year (95 % CI: 39,700-40,300). It represents a significant burden due to the large number of visits, antibiotic use, associated surgical procedures and need for auditory rehabilitation.

title: [Epidemiology and burden of XXXX in Valencia (Spain)].

answer: @entity3


abstract: Thirty-eight @entity0 with @entity4 who had background @entity3 and no residual endogenous insulin secretion as assessed by plasma C-peptide determinations, were randomized to either conventional insulin treatment or to more intensive @entity2 control using ultralente insulin as basal cover and soluble insulin at mealtimes and were followed for five years. Plasma @entity2 profile and glycosylated hemoglobin were determined every eight weeks. Eye examinations were performed at the start of the study and after one, three and five years. Age, duration of @entity1 , insulin dosage, glycemic control were comparable in the two groups. The mean plasma @entity2 profile was similar at entry in both groups and did not change in the conventionally-treated group. Mean plasma @entity2 profile 11.2 +/- 1 mmol/l with glycosylated hemoglobin level 10.7 +/- 0.3% fell to 7.9 +/- 0.4 mmol/l and 8.7 +/- 0.5% respectively during intensive treatment. Retinal morphology deteriorated during the follow-up with no significant differences between @entity0 under unchanged conventional treatment and intensive insulin regimen. @entity3 developed in six @entity0 --three of these were under intensive insulin treatment. These data suggest that substantial long-term improvement of glycemic control does not affect progression of background @entity3 even when it is mild. The evolution of established @entity3 in insulin dependent @entity1 @entity0 is not only a function of poor glycemic control; other factors, either intrinsic or environmental, must also be important.

title: Long-term correction of hyperglycemia and @entity3 in XXXX . A five-year randomized prospective study.

answer: @entity4


abstract: Thirty-eight @entity0 with @entity4 who had background @entity3 and no residual endogenous insulin secretion as assessed by plasma C-peptide determinations, were randomized to either conventional insulin treatment or to more intensive @entity2 control using ultralente insulin as basal cover and soluble insulin at mealtimes and were followed for five years. Plasma @entity2 profile and glycosylated hemoglobin were determined every eight weeks. Eye examinations were performed at the start of the study and after one, three and five years. Age, duration of @entity1 , insulin dosage, glycemic control were comparable in the two groups. The mean plasma @entity2 profile was similar at entry in both groups and did not change in the conventionally-treated group. Mean plasma @entity2 profile 11.2 +/- 1 mmol/l with glycosylated hemoglobin level 10.7 +/- 0.3% fell to 7.9 +/- 0.4 mmol/l and 8.7 +/- 0.5% respectively during intensive treatment. Retinal morphology deteriorated during the follow-up with no significant differences between @entity0 under unchanged conventional treatment and intensive insulin regimen. @entity3 developed in six @entity0 --three of these were under intensive insulin treatment. These data suggest that substantial long-term improvement of glycemic control does not affect progression of background @entity3 even when it is mild. The evolution of established @entity3 in insulin dependent @entity1 @entity0 is not only a function of poor glycemic control; other factors, either intrinsic or environmental, must also be important.

title: Long-term correction of hyperglycemia and XXXX in @entity4 . A five-year randomized prospective study.

answer: @entity3


abstract: OBJECTIVES: Perimenopause, the transition into menopause, marks the beginning of accelerated @entity3 , contributing to the development of @entity2 , a major public health problem. This perimenopausal transition has also been associated with a decrease in body lean mass, an increase in fat mass, and an increase in body weight. How these changes in fat mass and lean mass may influence @entity1 ( @entity1 ) is currently unknown. The purpose of this study is to determine the independent effect and relative contribution of lean mass and fat mass to @entity1 in perimenopausal @entity0 . MATERIAL AND METHODS: The sample consisted of 43 sedentary perimenopausal @entity0 (age: mean = 49.6; S.D. = 3.2) with an intact uterus and ovaries, participating in a study of exercise and perimenopausal symptoms. Total body @entity1 , regional @entity1 , and soft tissue body composition were measured by dual-energy X-ray absorptiometry. Other measures including age, height, weight, and serum FSH and E2 were also obtained. RESULTS: Findings revealed that 14% of these perimenopausal @entity0 had low bone mass ( @entity4 ) in the lumbar spine and/or the femoral neck. Overall body fat mass and lean mass had positive relationships with @entity1 of lumber spine and the femur. However, using multiple regression analyses, only lean mass and ethnicity remained significant predictors for @entity1 of the femoral neck (r2 = 45%) with lean mass explaining more variance than ethnicity. Lean mass was the sole predictor of total proximal femur @entity1 explaining 38% of the variance. Fat mass was not a significant predictor of @entity1 at any skeleton site. CONCLUSIONS: These findings suggest that body lean mass, not fat mass, is a significant contributor to femoral @entity1 in perimenopausal @entity0 .

title: Relationship between soft tissue body composition and bone mass in perimenopausal XXXX .

answer: @entity0


abstract: Psychiatric emergency services (PES) are an increasingly important component of mental health services. To assess the type and scope of services delivered in the PES setting, the American Association for Emergency Psychiatry sponsored an Expert Consensus Panel Survey of these services in 1999. The questionnaire was mailed to medical directors of PES facilities with 91% (n = 51) responding. More than 90% of the respondents were teaching sites. Restraints were reportedly used in a mean of 8.5% of presentations for a mean of 3.3 h per episode. Restraint utilization correlated with the percentage of @entity4 @entity0 treated, but not with a wide variety of other @entity0 and service variables. Involuntary medications were used in 16% of cases, though in oral form in 29% of those cases. A large majority (94%) endorsed mild sedation permitting further assessment as the appropriate endpoint and rejected sleep or heavy sedation as an endpoint (82%). @entity7 received the strongest endorsements and 82% indicated it would be appropriate to administer a @entity7 alone for agitation first and initiate antipsychotic treatment subsequently if appropriate. When there is no history of prior antipsychotic exposure, 60% favored a @entity7 alone. However, given a history of previous antipsychotic treatment, only 8% endorsed this strategy. Most respondents (78%) preferred to use oral medication for treating @entity1 , whenever possible but 70.3% reported regular use of an IM combination of a @entity7 and high-potency typical neuroleptic when necessary. In addition to managing @entity3 , 82% of services initiated standing medications for @entity0 being admitted to hospital settings and 70% initiated regular medication treatments for @entity0 being released to the community. Of @entity0 started on oral antipsychotics, 42% received an atypical antipsychotic. Reflecting medication characteristics of particular importance in emergency settings, most respondents (92%) cited selective @entity5 reuptake inhibitors as the preferred type of antidepressant, and @entity6 or related compounds (90%) for treatment of @entity2 in the PES.

title: Use of restraints and pharmacotherapy in XXXX .

answer: @entity1


abstract: @entity2 of the biliary system is a complex syndrome of ectasies of the intra-, extra- or both situation of biliary tree. This disease has an unsure etiopathogeny. It is uncommon through the third age, with a greater incidence in @entity0 , teen-ager and young adult. The goal of our study is to evaluate the symptoms, diagnosis, treatment and histological aspects of the congenital @entity7 . We performed a retrospective study from March 1988 to July 2003 about 11 @entity0 with this disease treated in our surgical clinic. Clinical features, methods of diagnosis and surgical treatment were assessed. All @entity0 were females with mean age 51 years (extreme 26-77 years). The symptoms were: right upper @entity3 --11 cases (100%), @entity6 --6 cases (54.5%), fever--3 cases (27%), palpable abdominal mass--2 cases (18%), weight loss--1 case (9%). The imaging diagnosis was helpful (ultrasonography, CT, ERCP, percutaneous cholangiography and preoperative cholangiography). In concordance with Todani classification the @entity0 were included in the following types: @entity13 cases (27%), I b--1 case (9%), I c--3 cases (27%), IV a--2 cases (18%), IV b--1 case (9%), V--1 case (9%). All @entity0 were operated on: after cholecystectomy and transcystic cholangiography (11 cases--100%) we performed the total excision of the cyst--9 cases (82%) with choledochal jejunostomy (Roux-en-Y)--6 cases (54.5%), choledochal jejunostomy (omega)--1 case (9%) and choledochal duodenostomy--2 cases (18%). In one case of neoplasic cyst with portal invasion we performed a cyst-jejunostomy (omega) and in one case of @entity12 with @entity11 , the solution of choice was choledocal-duodenostomy. The microscopic pathology of the cyst wall showed: chronic intramural inflammation--9 cases (82%) and the absence of the nervous intramural terminations--1 case (9%). The additional lesions was: hepatic cirrhosis--1 case (9%) and @entity8 --3 cases (27%). We found three cases with @entity1 : malign cyst with advanced local invasion--1 case (9%), @entity10 --1 case (9%) and @entity5 (microscopic finding)--1 case (9%). The postoperative morbidity includes @entity9 --2 cases (18%) and wound infection--2 cases (18%). Long-term follow-up revealed @entity4 in one case--9%. The cystic dilatations of the common bile duct is an exclusive indication for surgery as soon as it was discovered.

title: [ XXXX of the biliary system in adults].

answer: @entity2


abstract: All cases of early onset @entity3 ( @entity3 ) @entity1 in @entity0 born at Karolinska Hospital 1975-1986 were reviewed. @entity3 was diagnosed in 40 @entity0 within the first five days of life. The incidence was 1.24 per 1000 births. Fifty-five percent of the @entity0 were preterm and 48% were born more than or equal to 12 hours after @entity2 . Prematurity and/or prolonged @entity2 were present in 83% of all neonates with fatal outcome. Case fatality was 22%. Deliveries by both cesarean section (31%) and vacuum extraction (26%) were increased in the mothers when compared to an overall incidence of 14 and 12% (p less than 0.01). Twenty-four (89%) of 27 mothers had low type specific IgG antibodies against the infecting @entity3 -serotype. Late onset @entity3 was diagnosed in only two @entity0 during the period. Seventeen mothers went through 24 subsequent pregnancies. In 11 of those the mothers were colonized with @entity3 and 10 received penicillin prophylaxis during pregnancy and/or delivery. None of the @entity0 born after prophylaxis were colonized with @entity3 . Two were born prematurely and all had an uneventful course; whereas one @entity0 delivered at 26 weeks gestation of a colonized untreated mother died of @entity3 . Screening of parturients at risk and selective antibiotic prophylaxis may help to prevent early onset @entity3 .

title: XXXX due to group B streptococci--perinatal risk factors and outcome of subsequent pregnancies.

answer: @entity1


abstract: BACKGROUND: The @entity3 is a common risk factor for @entity1 . OBJECTIVE: To examine the association between the @entity3 and risk for @entity6 and microalbuminuria. DESIGN: Cross-sectional study. SETTING: The Third National Health and Nutrition Examination Survey. @entity0 : @entity0 20 years of age or older were studied in the @entity6 (n = 6217) and microalbuminuria (n = 6125) analyses. MEASUREMENTS: The @entity3 was defined as the presence of 3 or more of the following risk factors: elevated blood pressure, low high-density lipoprotein @entity2 level, high @entity4 level, elevated @entity5 level, and @entity8 . @entity6 was defined as a glomerular filtration rate less than 60 mL/min per 1.73 m2, and microalbuminuria was defined as a urinary albumin- @entity7 ratio of 30 to 300 mg/g. RESULTS: The multivariate-adjusted odds ratios of @entity6 and microalbuminuria in @entity0 with the @entity3 compared with @entity0 without the @entity3 were 2.60 (95% CI, 1.68 to 4.03) and 1.89 (CI, 1.34 to 2.67), respectively. Compared with @entity0 with 0 or 1 component of the @entity3 , @entity0 with 2, 3, 4, and 5 components of @entity6 had multivariate-adjusted odds ratios of 2.21 (CI, 1.16 to 4.24), 3.38 (CI, 1.48 to 7.69), 4.23 (CI, 2.06 to 8.63), and 5.85 (CI, 3.11 to 11.0), respectively. The corresponding multivariate-adjusted odds ratios of microalbuminuria for @entity0 with 3, 4, and 5 components were 1.62 (CI, 1.10 to 2.38), 2.45 (CI, 1.55 to 3.85), and 3.19 (CI, 1.96 to 5.19), respectively. CONCLUSIONS: These findings suggest that the @entity3 might be an important factor in the cause of @entity6 .

title: The @entity3 and XXXX in U.S. adults.

answer: @entity6


abstract: BACKGROUND: The @entity3 is a common risk factor for @entity1 . OBJECTIVE: To examine the association between the @entity3 and risk for @entity6 and microalbuminuria. DESIGN: Cross-sectional study. SETTING: The Third National Health and Nutrition Examination Survey. @entity0 : @entity0 20 years of age or older were studied in the @entity6 (n = 6217) and microalbuminuria (n = 6125) analyses. MEASUREMENTS: The @entity3 was defined as the presence of 3 or more of the following risk factors: elevated blood pressure, low high-density lipoprotein @entity2 level, high @entity4 level, elevated @entity5 level, and @entity8 . @entity6 was defined as a glomerular filtration rate less than 60 mL/min per 1.73 m2, and microalbuminuria was defined as a urinary albumin- @entity7 ratio of 30 to 300 mg/g. RESULTS: The multivariate-adjusted odds ratios of @entity6 and microalbuminuria in @entity0 with the @entity3 compared with @entity0 without the @entity3 were 2.60 (95% CI, 1.68 to 4.03) and 1.89 (CI, 1.34 to 2.67), respectively. Compared with @entity0 with 0 or 1 component of the @entity3 , @entity0 with 2, 3, 4, and 5 components of @entity6 had multivariate-adjusted odds ratios of 2.21 (CI, 1.16 to 4.24), 3.38 (CI, 1.48 to 7.69), 4.23 (CI, 2.06 to 8.63), and 5.85 (CI, 3.11 to 11.0), respectively. The corresponding multivariate-adjusted odds ratios of microalbuminuria for @entity0 with 3, 4, and 5 components were 1.62 (CI, 1.10 to 2.38), 2.45 (CI, 1.55 to 3.85), and 3.19 (CI, 1.96 to 5.19), respectively. CONCLUSIONS: These findings suggest that the @entity3 might be an important factor in the cause of @entity6 .

title: The XXXX and @entity6 in U.S. adults.

answer: @entity3


abstract: AIM: To verify the occurrence of @entity1 in @entity0 with chronic @entity2 ( @entity2 ) and to provide a more detailed description of the impairment's character and context. METHODS: Thirty (30) @entity0 with chronic @entity2 and 30 matched healthy controls completed a cognitive test battery. Four computerised tests were used: a) two different types of cognitive tasks (reaction time vs. working memory) and b) two types of information processing (verbal vs. spatial). Before testing and after every randomised subtest, subjects rated their @entity3 level on a visual analogue scale. RESULTS: A worse overall performance among @entity0 with @entity2 and, specifically, worse results concerning working memory tasks were found. Post-hoc testing revealed a statistically significant difference concerning the single variable "verbal reaction time". @entity3 intensity among @entity0 increased significantly during testing. @entity3 intensity after the subtest for verbal mental reaction time (independent of test sequence) was significantly correlated with results in this subtest, the more @entity3 , the more time was needed. CONCLUSION: Compared to healthy controls, @entity0 performed worse overall. Concerning verbal reaction time, the impairment was correlated with @entity3 intensity. The findings support the hypothesis that @entity3 might be one important factor leading to @entity1 in @entity0 with chronic @entity2 .

title: @entity1 in @entity0 with chronic XXXX --a matched control study.

answer: @entity2


abstract: AIM: To verify the occurrence of @entity1 in @entity0 with chronic @entity2 ( @entity2 ) and to provide a more detailed description of the impairment's character and context. METHODS: Thirty (30) @entity0 with chronic @entity2 and 30 matched healthy controls completed a cognitive test battery. Four computerised tests were used: a) two different types of cognitive tasks (reaction time vs. working memory) and b) two types of information processing (verbal vs. spatial). Before testing and after every randomised subtest, subjects rated their @entity3 level on a visual analogue scale. RESULTS: A worse overall performance among @entity0 with @entity2 and, specifically, worse results concerning working memory tasks were found. Post-hoc testing revealed a statistically significant difference concerning the single variable "verbal reaction time". @entity3 intensity among @entity0 increased significantly during testing. @entity3 intensity after the subtest for verbal mental reaction time (independent of test sequence) was significantly correlated with results in this subtest, the more @entity3 , the more time was needed. CONCLUSION: Compared to healthy controls, @entity0 performed worse overall. Concerning verbal reaction time, the impairment was correlated with @entity3 intensity. The findings support the hypothesis that @entity3 might be one important factor leading to @entity1 in @entity0 with chronic @entity2 .

title: XXXX in @entity0 with chronic @entity2 --a matched control study.

answer: @entity1


abstract: AIM: To verify the occurrence of @entity1 in @entity0 with chronic @entity2 ( @entity2 ) and to provide a more detailed description of the impairment's character and context. METHODS: Thirty (30) @entity0 with chronic @entity2 and 30 matched healthy controls completed a cognitive test battery. Four computerised tests were used: a) two different types of cognitive tasks (reaction time vs. working memory) and b) two types of information processing (verbal vs. spatial). Before testing and after every randomised subtest, subjects rated their @entity3 level on a visual analogue scale. RESULTS: A worse overall performance among @entity0 with @entity2 and, specifically, worse results concerning working memory tasks were found. Post-hoc testing revealed a statistically significant difference concerning the single variable "verbal reaction time". @entity3 intensity among @entity0 increased significantly during testing. @entity3 intensity after the subtest for verbal mental reaction time (independent of test sequence) was significantly correlated with results in this subtest, the more @entity3 , the more time was needed. CONCLUSION: Compared to healthy controls, @entity0 performed worse overall. Concerning verbal reaction time, the impairment was correlated with @entity3 intensity. The findings support the hypothesis that @entity3 might be one important factor leading to @entity1 in @entity0 with chronic @entity2 .

title: @entity1 in XXXX with chronic @entity2 --a matched control study.

answer: @entity0


abstract: @entity3 may result in variations of its mechanical properties. The published data of the @entity2 of small animals, such as @entity0 and @entity1 , are exclusively obtained by measuring grip-to-grip (g-t-g) displacement. Local strain concentration and relative sliding of the specimens in the clamps might significantly affect the measured tendon deformation. In the present study, the mechanical properties of the @entity1 tibialis anterior tendon measured using the proposed tendon mark method were compared to those evaluated using the g-t-g displacement method. Five male @entity1 ( approximately 418 g) were used in this study. For the proposed method, reference marks were made on the tendons using permanent ink. A microscope video system was customized to observe and record the tendon deformation. Pattern recognition software was developed to obtain the displacement time-histories of the reference marks. The distance between the grips was approximately 7 mm; and the distance between the reference marks used for the data processing was approximately 5 mm. The cross-section areas of the specimens were measured using a custom-made slot gauge and by applying a constant compressive stress (0.15 MPa). The tendons were clamped between two custom-made metal grips and stretched on a testing machine at a constant speed (1 mm/s) up to failure. Throughout the tests, the tendon specimens were submerged in a PBS bath at 22 degrees C. The deformation of the specimens was evaluated using the g-t-g displacement method and the proposed method. The stress/strain curves obtained by using the g-t-g displacement can be characterized by an initial toe zone, a quasi-linear zone, and a final failure stage. The stress/strain curves determined using the proposed method are quite different from those obtained using the g-t-g displacement: it has a smaller toe zone and a stress-hardening transition, over which the @entity2 increases dramatically with the increasing strain. The @entity2 measured by using the g-t-g displacement method may underestimate the actual mechanical properties of tendon by approximately 43%.

title: Comparison of mechanical properties of XXXX tibialis anterior tendon evaluated using two different approaches.

answer: @entity1


abstract: Fifty-three serum-resistant strains of @entity0 which were all able to grow in at least 50% @entity1 ( @entity1 ) were tested in respect to binding and consumption of C3b, factor H, C5, and C6 after incubation in pooled @entity1 . The results of immunofluorescence tests, hemolytic assays, and binding studies using radiolabeled components were comparable. The different binding patterns allowed us to divide the strains into three different groups. The main features of group I were the attachment of C3, C5, and C6 to the bacterial cells as well as consumption of C3 and C5, whereas factor H did not bind at all or only in small amounts. In addition, released MAC was detectable in the supernatant of reaction mixtures containing bacteria of a group I strain and @entity1 . In group II factor H was easily bound to the bacteria, but no C3, C5, and C6 binding or C5 consumption was detectable. In addition, strains of group III bound C3 and factor H and some strains also bound and consumed C5. Because of the inhomogeneity of group III, this investigation was restricted to a comparison of groups I and II. From the results presented in this study we conclude that group I bacteria activate the whole complement cascade, whereas with bacteria of group II, complement activation is interrupted at the C3 level. These findings therefore indicate a second, alternative mechanism of serum resistance in @entity0 .

title: Two different mechanisms of serum resistance in XXXX .

answer: @entity0


abstract: BACKGROUND: There is currently a great need for an in vitro assay to assess the presence of tolerance following allotransplantation to determine whether immunosuppressive medications can be discontinued. Our laboratory has recently developed an assay involving coculture inhibition of cell-mediated lympholysis that correlates with tolerance to allografts in swine leukocyte antigen (SLA) Class I-mismatched miniature @entity3 . The potential for clinical application of this assay may depend on 2 important factors: (1) whether the assay can be used in the presence of immunosuppression; and (2) whether frozen-stored naive responder cells can be utilized. METHODS: Long-term tolerant MGH miniature @entity3 that had accepted SLA Class I-mismatched kidney transplants after a 12-day course of @entity1 or @entity2 were studied. Two long-term tolerant and 2 naive control animals were treated with a clinically relevant dose of @entity1 for 2 weeks (trough level 100 to 400 ng/ml) to simulate the ongoing "chronic" immunosuppression used in @entity0 recipients of allografts. Cells from tolerant or naive, recipient-matched animals were stimulated for 6 days with donor or third-party SLA. These primed cells were then cocultured with naive unstimulated recipient major histocompatibility complex (MHC)-matched responders and irradiated stimulators. Responder cells were tested both fresh and frozen. RESULTS: Suppression of cytotoxic responses of naive responder cells was observed in all coculture assays using cells from tolerant animals primed against donor antigen in vitro, but not in assays using similarly primed cells from naive animals. Responder cells from tolerant animals receiving immunosuppression had a suppressive activity similar to that from cells of the same animals not receiving immunosuppression. Similar suppression was also observed in coculture assays using either fresh or frozen naive responder cells. CONCLUSIONS: This coculture assay appears to correlate with the presence of tolerance under conditions applicable to the clinical setting. The assay appears to identify peripheral regulatory mechanisms of tolerance in allogeneic transplant recipients, and therefore may provide an approach for determining an appropriate timepoint at which to test withdrawal of immunosuppressive medications.

title: Detection of regulatory cells as an assay for allograft tolerance in miniature XXXX .

answer: @entity3


abstract: Area-restricted search (ARS) is a foraging strategy used by many animals to locate resources. The behavior is characterized by a time-dependent reduction in turning frequency after the last resource encounter. This maximizes the time spent in areas in which resources are abundant and extends the search to a larger area when resources become scarce. We demonstrate that dopaminergic and glutamatergic signaling contribute to the neural circuit controlling ARS in the @entity1 @entity1 . Ablation of dopaminergic neurons eliminated ARS behavior, as did application of the @entity0 receptor antagonist @entity4 . Furthermore, ARS was affected by mutations in the @entity2 receptor subunits @entity5 and @entity6 and the @entity7 @entity2 vesicular transporter. Interestingly, preincubation on @entity0 restored the behavior in worms with @entity3 , but not in @entity5 , @entity6 , or @entity7 mutants. This suggests that dopaminergic and glutamatergic signaling function in the same pathway to regulate turn frequency. Both @entity5 and @entity6 are expressed in the locomotory control circuit that modulates the direction of locomotion in response to sensory stimuli and the duration of forward movement during foraging. We propose a mechanism for ARS in @entity1 in which @entity0 , released in response to food, modulates glutamatergic signaling in the locomotory control circuit, thus resulting in an increased turn frequency.

title: @entity0 and XXXX control area-restricted search behavior in @entity1 .

answer: @entity2


abstract: Area-restricted search (ARS) is a foraging strategy used by many animals to locate resources. The behavior is characterized by a time-dependent reduction in turning frequency after the last resource encounter. This maximizes the time spent in areas in which resources are abundant and extends the search to a larger area when resources become scarce. We demonstrate that dopaminergic and glutamatergic signaling contribute to the neural circuit controlling ARS in the @entity1 @entity1 . Ablation of dopaminergic neurons eliminated ARS behavior, as did application of the @entity0 receptor antagonist @entity4 . Furthermore, ARS was affected by mutations in the @entity2 receptor subunits @entity5 and @entity6 and the @entity7 @entity2 vesicular transporter. Interestingly, preincubation on @entity0 restored the behavior in worms with @entity3 , but not in @entity5 , @entity6 , or @entity7 mutants. This suggests that dopaminergic and glutamatergic signaling function in the same pathway to regulate turn frequency. Both @entity5 and @entity6 are expressed in the locomotory control circuit that modulates the direction of locomotion in response to sensory stimuli and the duration of forward movement during foraging. We propose a mechanism for ARS in @entity1 in which @entity0 , released in response to food, modulates glutamatergic signaling in the locomotory control circuit, thus resulting in an increased turn frequency.

title: XXXX and @entity2 control area-restricted search behavior in @entity1 .

answer: @entity0


abstract: Area-restricted search (ARS) is a foraging strategy used by many animals to locate resources. The behavior is characterized by a time-dependent reduction in turning frequency after the last resource encounter. This maximizes the time spent in areas in which resources are abundant and extends the search to a larger area when resources become scarce. We demonstrate that dopaminergic and glutamatergic signaling contribute to the neural circuit controlling ARS in the @entity1 @entity1 . Ablation of dopaminergic neurons eliminated ARS behavior, as did application of the @entity0 receptor antagonist @entity4 . Furthermore, ARS was affected by mutations in the @entity2 receptor subunits @entity5 and @entity6 and the @entity7 @entity2 vesicular transporter. Interestingly, preincubation on @entity0 restored the behavior in worms with @entity3 , but not in @entity5 , @entity6 , or @entity7 mutants. This suggests that dopaminergic and glutamatergic signaling function in the same pathway to regulate turn frequency. Both @entity5 and @entity6 are expressed in the locomotory control circuit that modulates the direction of locomotion in response to sensory stimuli and the duration of forward movement during foraging. We propose a mechanism for ARS in @entity1 in which @entity0 , released in response to food, modulates glutamatergic signaling in the locomotory control circuit, thus resulting in an increased turn frequency.

title: @entity0 and @entity2 control area-restricted search behavior in XXXX .

answer: @entity1


abstract: The subject was a 34-year-old female with @entity4 and @entity2 who had previously undergone a Cesarean section. In December 1995, the @entity0 had an acute @entity3 , so she underwent a barium enema examination. During the procedure, severe @entity6 shock developed, and the examination was stopped. The @entity0 responded well to appropriate emergency therapy, and her symptoms were resolved. However, the @entity0 visited our outpatient clinic because the symptoms of her @entity2 got worse. She indicated that she felt itchy when using rubber gloves. Also, at the age of thirty, she had @entity1 and @entity5 after drinking a glass of fruit juice. Subsequently radioallergosorbent testing demonstrated the presence of specific IgEs against latex, banana, kiwi, grapefruit, and avocado. Skin prick tests were positive for banana, grapefruit, avocado, and latex extract at a dilution of 1:1000. A scratch test was positive to an extract of a balloon catheter which included 0.3 microg/g latex proteins by the LEAP method. In conclusion, the @entity0 was diagnosed with an @entity6 to the latex contained in a balloon catheter used for the barium enema.

title: [A case of the latex-induced XXXX by contact with barium enema catheter].

answer: @entity6


abstract: Sixty-eight @entity0 received fractionated @entity2 ( @entity2 ) as treatment for @entity5 ( @entity5 ) at the Rotterdamsch Radio-Therapeutisch Instituut (RRTI) in the period 1973-1979. Ninety percent (61/68) of these @entity0 had @entity4 (Stage III + IV). According to current @entity1 grade classifications, 34 @entity0 had low grade @entity5 , 10 intermediate, and 19 high grade. In 5 cases no exact grading was possible. @entity2 was given 3 times a week, midline dose 0.1 Gy, using 6 or 25 MeV photons to a mean total dose of 1.78 Gy. Initial response rate for low, intermediate, and high grade @entity5 was resp. 84, 42, and 40%. The main prognostic factor for survival and @entity3 ( @entity3 ) was @entity1 grade. Probability of uncorrected survival at 10 years for low, intermediate, and high grade was resp. 34, 0 and 0%. Probability of @entity3 at 10 years was resp. 19, 0, and 0%. Neither stage nor sex had any influence on survival. Age was reversely correlated with survival, but was not correlated with @entity3 . Influence of prior therapy (18 @entity0 ) on survival and @entity3 was separately analyzed. Neither survival nor @entity3 of unfavorable @entity5 (high and intermediate grade) was influenced. On the other hand @entity0 with a favorable @entity5 (low grade) had a significantly (p less than 0.05) better @entity3 if they received @entity2 as initial treatment, but survival was not significantly influenced. @entity3 at 5 and 10 years of @entity0 who received @entity2 as first treatment was respectively 32% and 27%. No treatment related complications were noted. Subsequent chemotherapy in case of relapse was not hampered by previous @entity2 . The high response rate and extended @entity3 , without maintenance therapy, makes @entity2 a preferable first line treatment for @entity0 with advanced stage low grade @entity5 .

title: Long-term results of XXXX for advanced @entity5 .

answer: @entity2


abstract: Sixty-eight @entity0 received fractionated @entity2 ( @entity2 ) as treatment for @entity5 ( @entity5 ) at the Rotterdamsch Radio-Therapeutisch Instituut (RRTI) in the period 1973-1979. Ninety percent (61/68) of these @entity0 had @entity4 (Stage III + IV). According to current @entity1 grade classifications, 34 @entity0 had low grade @entity5 , 10 intermediate, and 19 high grade. In 5 cases no exact grading was possible. @entity2 was given 3 times a week, midline dose 0.1 Gy, using 6 or 25 MeV photons to a mean total dose of 1.78 Gy. Initial response rate for low, intermediate, and high grade @entity5 was resp. 84, 42, and 40%. The main prognostic factor for survival and @entity3 ( @entity3 ) was @entity1 grade. Probability of uncorrected survival at 10 years for low, intermediate, and high grade was resp. 34, 0 and 0%. Probability of @entity3 at 10 years was resp. 19, 0, and 0%. Neither stage nor sex had any influence on survival. Age was reversely correlated with survival, but was not correlated with @entity3 . Influence of prior therapy (18 @entity0 ) on survival and @entity3 was separately analyzed. Neither survival nor @entity3 of unfavorable @entity5 (high and intermediate grade) was influenced. On the other hand @entity0 with a favorable @entity5 (low grade) had a significantly (p less than 0.05) better @entity3 if they received @entity2 as initial treatment, but survival was not significantly influenced. @entity3 at 5 and 10 years of @entity0 who received @entity2 as first treatment was respectively 32% and 27%. No treatment related complications were noted. Subsequent chemotherapy in case of relapse was not hampered by previous @entity2 . The high response rate and extended @entity3 , without maintenance therapy, makes @entity2 a preferable first line treatment for @entity0 with advanced stage low grade @entity5 .

title: Long-term results of @entity2 for advanced XXXX .

answer: @entity5


abstract: We report a case displaying upper motor sign, @entity6 , and @entity2 , with marked degeneration of the precentral cortex, neostriatum and frontotemporal lobes, as well as ubiquitinated neuronal inclusions. The @entity0 was a 66-year-old male at the time of @entity4 . At age 57, he noticed progressive difficulties in speaking and swallowing. At age 60, he was severely anarthric and displayed @entity12 and @entity7 . Neurologically, very poor movement of tongue was observed, but without @entity3 or @entity14 . Deep tendon reflexes were @entity15 . Grasp reflex and snout reflex were also positive. Needle electromyography revealed no abnormalities. A diagnosis of @entity16 and character change was made. At age 62, he developed @entity13 and @entity11 of the neck and all extremities. Treatment with carbidopa-levodopa was initiated, but resulted in minimal improvement. At age 65, he was bed-ridden, and had repeated occurrences of @entity9 ; he died of @entity1 . Neuropathological examination revealed marked @entity10 with Betz cells completely absent and moderate @entity3 . The spinal cord and nerve roots appeared normal. Immunohistochemically, ubiquitin-positive but tau-negative intraneuronal inclusions were found in the frontal and temporal cortices, including the precentral cortex and the hippocampal dentate gyrus, and the neostriatum. This case could be included with inclusion-associated disorders such as @entity17 or @entity8 with @entity5 , and furthermore, predominant upper motor sign and @entity6 could represent phenotypes of clinical manifestations with such inclusions.

title: @entity17 with ubiquitinated neuronal inclusions presenting with @entity16 and XXXX : clinicopathological report of an autopsy case.

answer: @entity6


abstract: We report a case displaying upper motor sign, @entity6 , and @entity2 , with marked degeneration of the precentral cortex, neostriatum and frontotemporal lobes, as well as ubiquitinated neuronal inclusions. The @entity0 was a 66-year-old male at the time of @entity4 . At age 57, he noticed progressive difficulties in speaking and swallowing. At age 60, he was severely anarthric and displayed @entity12 and @entity7 . Neurologically, very poor movement of tongue was observed, but without @entity3 or @entity14 . Deep tendon reflexes were @entity15 . Grasp reflex and snout reflex were also positive. Needle electromyography revealed no abnormalities. A diagnosis of @entity16 and character change was made. At age 62, he developed @entity13 and @entity11 of the neck and all extremities. Treatment with carbidopa-levodopa was initiated, but resulted in minimal improvement. At age 65, he was bed-ridden, and had repeated occurrences of @entity9 ; he died of @entity1 . Neuropathological examination revealed marked @entity10 with Betz cells completely absent and moderate @entity3 . The spinal cord and nerve roots appeared normal. Immunohistochemically, ubiquitin-positive but tau-negative intraneuronal inclusions were found in the frontal and temporal cortices, including the precentral cortex and the hippocampal dentate gyrus, and the neostriatum. This case could be included with inclusion-associated disorders such as @entity17 or @entity8 with @entity5 , and furthermore, predominant upper motor sign and @entity6 could represent phenotypes of clinical manifestations with such inclusions.

title: @entity17 with ubiquitinated neuronal inclusions presenting with XXXX and @entity6 : clinicopathological report of an autopsy case.

answer: @entity16


abstract: We report a case displaying upper motor sign, @entity6 , and @entity2 , with marked degeneration of the precentral cortex, neostriatum and frontotemporal lobes, as well as ubiquitinated neuronal inclusions. The @entity0 was a 66-year-old male at the time of @entity4 . At age 57, he noticed progressive difficulties in speaking and swallowing. At age 60, he was severely anarthric and displayed @entity12 and @entity7 . Neurologically, very poor movement of tongue was observed, but without @entity3 or @entity14 . Deep tendon reflexes were @entity15 . Grasp reflex and snout reflex were also positive. Needle electromyography revealed no abnormalities. A diagnosis of @entity16 and character change was made. At age 62, he developed @entity13 and @entity11 of the neck and all extremities. Treatment with carbidopa-levodopa was initiated, but resulted in minimal improvement. At age 65, he was bed-ridden, and had repeated occurrences of @entity9 ; he died of @entity1 . Neuropathological examination revealed marked @entity10 with Betz cells completely absent and moderate @entity3 . The spinal cord and nerve roots appeared normal. Immunohistochemically, ubiquitin-positive but tau-negative intraneuronal inclusions were found in the frontal and temporal cortices, including the precentral cortex and the hippocampal dentate gyrus, and the neostriatum. This case could be included with inclusion-associated disorders such as @entity17 or @entity8 with @entity5 , and furthermore, predominant upper motor sign and @entity6 could represent phenotypes of clinical manifestations with such inclusions.

title: XXXX with ubiquitinated neuronal inclusions presenting with @entity16 and @entity6 : clinicopathological report of an autopsy case.

answer: @entity17


abstract: PURPOSE: The aim of this study was to evaluate skeletal stability after double-jaw surgery for correction of skeletal @entity1 to assess whether there were any differences between wire and rigid fixation of the mandible. @entity0 AND METHODS: Thirty-seven Class III @entity0 had Le Fort I osteotomy stabilized with plate and screws for maxillary advancement. Bilateral sagittal split osteotomy for mandibular setback was stabilized with wire osteosynthesis and maxillomandibular fixation for 6 weeks in 20 @entity0 (group 1) and with rigid internal fixation in 17 @entity0 (group 2). Lateral cephalograms were taken before surgery, immediately after surgery, 8 weeks after surgery, and 1 year after surgery. RESULTS: Before surgery, both groups were balanced with respect to linear and angular measurements of craniofacial morphology. One year after surgery, maxillary sagittal stability was excellent in both groups, and bilateral sagittal split osteotomy accounted for most of the total horizontal relapse observed. In group 1, significant correlations were found between maxillary advancement and relapse at the posterior maxilla and between mandibular setback and postoperative counterclockwise rotation of the ramus and mandibular relapse. In group 2, significant correlations were found between mandibular setback and intraoperative clockwise rotation of the ramus and between mandibular setback and postoperative counterclockwise rotation of the ramus and mandibular relapse. No significant differences in postoperative skeletal and dental stability between groups were observed except for @entity2 . CONCLUSIONS: Surgical correction of @entity1 after combined maxillary and mandibular procedures appears to be a fairly stable procedure independent of the type of fixation used to stabilize the mandible.

title: Stability of skeletal XXXX after combined maxillary and mandibular procedures: rigid internal fixation versus wire osteosynthesis of the mandible.

answer: @entity1


abstract: BACKGROUND: This retrospective study was designed to evaluate the efficacy of tailored endoscopic surgery. Tailored endoscopic surgery aims at resecting the @entity3 completely with a customized surgical approach, especially when an en-bloc excision cannot be comprehensively or routinely achieved because of the immense extent of the @entity1 . METHODS: Between November 1991 and March 2002, 43 @entity0 with sinonasal @entity3 were treated by tailored endoscopic surgery. The average duration of follow-up for this population was 25.3 months (range, 9-150 months). A staging system developed by Krouse was adopted for @entity1 grading. On the basis of tailored endoscopic surgery, 15 localized lesions and 12 smaller extensive lesions (Krouse stages 1 and 2) were treated by ordinary endoscopic resection, whereas 16 larger extensive lesions (Krouse stages 3 and 4) in which the @entity1 were immense were subjected to sequential segmental endoscopic surgery (SSES). Seven of these 16 larger extensive lesions combined with endoscopic medial maxillectomy because of extensive encroachment of maxillary sinus antrum. RESULTS: Four @entity0 (9.3%) had @entity2 , each requiring one revision surgery. All @entity1 were successfully resected. No @entity0 required lateral rhinotomy or @entity4 procedure. No major complications were encountered in any of the @entity0 . None of the @entity0 had @entity2 at the time of this writing. CONCLUSIONS: Tailored endoscopic surgery is a safe and effective treatment that obviates the need for more extensive surgery for the management of @entity3 . Proper preoperative evaluations, intraoperative determination of extent and attachment of the @entity1 , close endoscopic follow-up, and expert application of endoscopic techniques are the keys to the successful use of tailored endoscopic surgery.

title: Tailored endoscopic surgery for the treatment of sinonasal XXXX .

answer: @entity3


abstract: BACKGROUND: Parapharyngeal space nodal @entity1 are usually secondary to @entity2 of the pharynx and sinonasal tract, although localization of @entity3 is also possible. Parapharyngeal @entity1 arising from @entity5 are instead an exceedingly rare event, with only 10 cases reported up to now in the literature. METHODS: We describe two cases of parapharyngeal @entity1 from @entity5 in a @entity0 and a @entity0 , aged 40 and 52 years, respectively. RESULTS: Both @entity0 had a lesion that clinically appeared to be located in the parapharyngeal space; they underwent CT and MRI, which detected a cystic mass in the poststyloid compartment. In the first @entity0 , fine-needle aspiration cytology failed in identifying the histologic nature of the lesion, which was excised through a transcervical approach. A diagnosis of @entity5 was rendered and therefore the @entity0 underwent total thyroidectomy. In the second @entity0 , a total thyroidectomy, previously scheduled for @entity4 , was performed along with the removal of the parapharyngeal mass. Definitive histologic findings revealed that the two parapharyngeal masses were cystic @entity1 from a @entity5 . Both @entity0 received postoperative 131I treatment. Twenty-four months after surgery, the first @entity0 is free of disease, whereas the second one has clear signs of abnormal 131I uptake in the lungs. CONCLUSIONS: The differential diagnosis of a parapharyngeal poststyloid mass should also include @entity1 from @entity5 . When the lesion displays a cystic appearance on imaging, it is advisable to rule out a thyroid primary by ultrasonographic examination. The occurrence of a @entity1 in such unusual site, even though rarely reported, does not seem to significantly affect the prognosis of the disease.

title: Parapharyngeal lymph node XXXX : an unusual presentation of @entity5 .

answer: @entity1


abstract: BACKGROUND: Parapharyngeal space nodal @entity1 are usually secondary to @entity2 of the pharynx and sinonasal tract, although localization of @entity3 is also possible. Parapharyngeal @entity1 arising from @entity5 are instead an exceedingly rare event, with only 10 cases reported up to now in the literature. METHODS: We describe two cases of parapharyngeal @entity1 from @entity5 in a @entity0 and a @entity0 , aged 40 and 52 years, respectively. RESULTS: Both @entity0 had a lesion that clinically appeared to be located in the parapharyngeal space; they underwent CT and MRI, which detected a cystic mass in the poststyloid compartment. In the first @entity0 , fine-needle aspiration cytology failed in identifying the histologic nature of the lesion, which was excised through a transcervical approach. A diagnosis of @entity5 was rendered and therefore the @entity0 underwent total thyroidectomy. In the second @entity0 , a total thyroidectomy, previously scheduled for @entity4 , was performed along with the removal of the parapharyngeal mass. Definitive histologic findings revealed that the two parapharyngeal masses were cystic @entity1 from a @entity5 . Both @entity0 received postoperative 131I treatment. Twenty-four months after surgery, the first @entity0 is free of disease, whereas the second one has clear signs of abnormal 131I uptake in the lungs. CONCLUSIONS: The differential diagnosis of a parapharyngeal poststyloid mass should also include @entity1 from @entity5 . When the lesion displays a cystic appearance on imaging, it is advisable to rule out a thyroid primary by ultrasonographic examination. The occurrence of a @entity1 in such unusual site, even though rarely reported, does not seem to significantly affect the prognosis of the disease.

title: Parapharyngeal lymph node @entity1 : an unusual presentation of XXXX .

answer: @entity5


abstract: The presence of acute @entity8 is not uncommon in severely ill @entity0 and is considered by some to be a contraindication to heart transplantation. It has been our policy to accept these @entity0 for operation. The purpose of this investigation is to examine the results of this policy in @entity0 receiving immunosuppression with @entity2 and @entity6 . Between September 1982 and April 1985, eight @entity0 undergoing heart transplantation demonstrated clinical and radiographic evidence of acute preoperative @entity8 . These @entity0 represented 5.5% of our heart transplantation population during this period (total = 145). The age range in these eight @entity0 was from 22 to 55 years. @entity5 was present in four @entity0 , and four @entity0 had @entity4 . All @entity0 were New York Heart Association functional status class IV. Five of the eight @entity0 were on inotropic support, and one @entity0 had associated @entity1 . @entity8 were located in the right, middle, or lower lung field in seven @entity0 and in the left lower lung field in one @entity0 . All @entity0 were treated perioperatively by intensive physiotherapy and specific antibiotics. In four @entity0 the lesions resolved on medical treatment alone. Three @entity0 developed extensive @entity7 and required chest drainage with or without decortication. Two of these @entity0 survived with complete resolution of the lung lesions, and one @entity0 died from prolonged @entity1 and @entity3 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: The influence of acute preoperative XXXX on the results of heart transplantation.

answer: @entity8


abstract: Few data exist on the effects of specific @entity3 ( @entity3 )-related mutations on cognitive function. We present neuropsychological test results in eight members of a large kindred with variant @entity3 (VarAD) due to a deletion of the @entity7 ( @entity7 ) gene, encompassing exon 9. The disease was neuropathologically characterized by the presence of large, unusual, " @entity6 wool" plaques (CWP). Four surviving @entity0 were prospectively tested, and retrospective neuropsychological data were collected from additional four deceased @entity0 . The neuropsychological evaluation was based on tests of @entity4 , abstract thinking, and visuoconstructive and spatial functions. In addition, @entity2 symptoms were evaluated. In four @entity0 , brain @entity5 metabolism was examined by positron emission tomography (PET). PET showed temporoparietal hypometabolism typical of @entity3 . In addition, variable patterns of hypometabolism (hemispherical asymmetry and occipital accentuation) were related to individual deficits of cognitive performance. However, all these early-onset @entity0 (age range 43-63 years) with a deletion mutation of @entity7 gene showed prominent @entity1 in visuoconstructive and intellectual functions.

title: Neuropsychological functions in variant XXXX with spastic paraparesis.

answer: @entity3


abstract: Although there has been considerable research on @entity2 and their effect on physical and mental health, there has been little research into the effects of psychosocial domestic conditions on health. The association between @entity2 (and control at work in particular) and @entity1 ( @entity1 ) is not as strong for @entity0 compared to @entity0 . Other research suggests that household and domestic factors may have an important effect on @entity0 's health. Some studies have shown that low control at home affects psychological well being. However, there has been little research into its effects on physical health. Furthermore, similar to results analysing low control at work, low control at home may form part of the pathways underlying social inequalities in health. The study investigates the meaning of control at home, the effect of control at home on incident @entity1 events and whether this explains some of the social inequalities in @entity1 events in @entity0 and @entity0 . Data from phases 3-5 of the Whitehall II study, London, UK, were analysed (N = 7470). The results indicate that low control at home predicts @entity1 among @entity0 but not among @entity0 . Furthermore, low control at home may explain part of the association between household social position and @entity1 among @entity0 . There is some evidence suggesting that low control at home among @entity0 results from a lack of material and psychological resources to cope with excessive household and family demands. Psychosocial domestic conditions may have a greater effect on the health of @entity0 compared with @entity0 .

title: The effect of control at home on XXXX events in the Whitehall II study: Gender differences in psychosocial domestic pathways to social inequalities in @entity1 .

answer: @entity1


abstract: Although there has been considerable research on @entity2 and their effect on physical and mental health, there has been little research into the effects of psychosocial domestic conditions on health. The association between @entity2 (and control at work in particular) and @entity1 ( @entity1 ) is not as strong for @entity0 compared to @entity0 . Other research suggests that household and domestic factors may have an important effect on @entity0 's health. Some studies have shown that low control at home affects psychological well being. However, there has been little research into its effects on physical health. Furthermore, similar to results analysing low control at work, low control at home may form part of the pathways underlying social inequalities in health. The study investigates the meaning of control at home, the effect of control at home on incident @entity1 events and whether this explains some of the social inequalities in @entity1 events in @entity0 and @entity0 . Data from phases 3-5 of the Whitehall II study, London, UK, were analysed (N = 7470). The results indicate that low control at home predicts @entity1 among @entity0 but not among @entity0 . Furthermore, low control at home may explain part of the association between household social position and @entity1 among @entity0 . There is some evidence suggesting that low control at home among @entity0 results from a lack of material and psychological resources to cope with excessive household and family demands. Psychosocial domestic conditions may have a greater effect on the health of @entity0 compared with @entity0 .

title: The effect of control at home on @entity1 events in the Whitehall II study: Gender differences in psychosocial domestic pathways to social inequalities in XXXX .

answer: @entity1


abstract: Lead is a common element in the earth's crust, serving useful purposes in industry, but serving no purpose in the @entity0 body. Increase in blood pressure is an important public health problem with numerous factors contributing to many facets of the disease. The relationship of lead exposure and increased blood pressure has long been considered, but only recently critically investigated. Reports of subtle changes in @entity3 metabolism and renal function, as well as in vitro studies examining end-arteriolar smooth muscle contractility, link lead exposure and increased blood pressure. This paper critically examines the evidence associating chronic low-level lead exposure and increased blood pressure. The review focuses on epidemiological, clinical, and toxicological data. The epidemiological evidence is consistent with low-level exposure to lead causing an elevation in blood pressure. The strength of that association, and the dose-response characteristics, are less certain. Individual resistance and susceptibility could affect the degree of blood pressure elevation. The results of animal and in vitro studies are consistent with the epidemiological evidence, and suggest biologically plausible mechanisms for the association. The most probable mechanisms are intracellular perturbations in @entity3 metabolism mediated by direct lead effects at the end-arteriole, and indirect effects via @entity1 . Better indices of lead exposure and lead activity are needed to quantify these effects in @entity0 . New and safer methods of chelating lead suggest interesting approaches for studying the relationship between lead and @entity2 . This link could have significant implications in determining what constitutes a 'safe' level of environmental lead exposure, and whether a proportion of essential @entity2 could be 'cured' by chelation therapy.

title: Chronic low-level lead exposure. Its role in the pathogenesis of XXXX .

answer: @entity2


abstract: The effect of highly purified natural porcine @entity5 on C-peptide release was examined in six type I (insulin-dependent) diabetics ( @entity4 ) with residual beta-cell function, six type II non-insulin-dependent) diabetics (NIDD), and six normal subjects. All subjects were normal weight. From -120 minutes to 180 minutes @entity2 or insulin was infused IV to achieve a constant plasma @entity2 level of 8 mmol/L. On two separate days @entity5 (2 pmol/kg/min) or isotonic @entity3 at random were infused from 0 to 30 minutes. After 10 minutes of @entity5 infusion plasma IR- @entity5 concentrations were in the physiologic postprandial range. At 30 minutes a further increase in IR- @entity5 to supraphysiologic levels occurred. In all subjects plasma, C-peptide increased more after 10 minutes of @entity5 infusion ( @entity4 , 0.48 +/- 0.05; NIDD, 0.79 +/- 0.11; normal subjects, 2.27 +/- 0.29 nmol/L) than on the corresponding day with @entity3 infusion ( @entity4 , 0.35 +/- 0.03; NIDD, 0.62 +/- 0.08; normal subjects, 1.22 +/- 0.13 nmol/L, P less than .05 for all). The responses of the diabetics were significantly lower than that of the normal subjects (P less than .001 for both groups). No further increase in C-peptide occurred during the remaining 20 minutes of the @entity5 infusion in the @entity1 subjects ( @entity4 , 0.49 +/- 0.05; NIDD, 0.83 +/- 0.10 nmol/L). In the presence of a plasma @entity2 concentration of 8 mmol/L, physiologic concentrations of porcine @entity5 caused an immediate but impaired beta-cell response in @entity4 and NIDD @entity0 .

title: Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and XXXX .

answer: @entity1


abstract: BACKGROUND: @entity2 is common, causing approximately 11% of @entity1 deaths in the UK. However, a GP would only expect to see one new presentation each year. Referral guidelines outlining clinical scenarios of high risk have been published. These aim to help GPs select @entity0 for rapid investigation. OBJECTIVES: The purpose of this study was to review the presenting features of @entity2 in primary care, using the basic structure of the UK Referral Guidelines for Suspected @entity1 . METHODS: A structured literature review was carried out. RESULTS: Two symptoms have a high predictive value for @entity1 : @entity6 and change in bowel habit towards increased looseness or increased stool frequency. Other symptoms, such as @entity5 , are so prevalent in the community that they have little predictive value. There is little published evidence on abdominal or rectal masses and @entity3 deficiency @entity4 as presenting features for @entity2 . However, these are so likely to have an important cause, investigation is mandated. Two areas in the Referral Guidelines are questioned: the need to defer investigation of change in bowel habit towards increased looseness or increased stool frequency for 6 weeks, and the low risk nature of @entity7 . CONCLUSION: The Referral Guidelines have a reasonable evidence base.

title: Diagnosis of XXXX in primary care: the evidence base for guidelines.

answer: @entity2


abstract: The development of targeted antitumor agent aiming the HER family of @entity4 kinase transmembrane receptors, focused on the issue of target detection. For @entity5 , the techniques used to detect an overexpression are well established and none has, to date, shown its superiority. These are immunohistochemistry (protein) and in situ fluorescent hybridization (DNA). For @entity3 , the diversity of the activation means (amplification, mutation, enhanced transcription, ligands...) leads to technical caveats. Immunohistochemistry appears to be the most appropriate test for clinical use but standardized assays and scoring systems are mandatory. The @entity3 levels of expression are very high in some normal tissues such as oral mucosae. In @entity1 , @entity3 levels are variable. The highest expression is found in head and neck @entity1 . @entity3 expression is also elevated in @entity2 . @entity3 testing may be required before targeted treatment. An exciting endpoint would be the functional and dynamic evaluation of @entity3 and downstream proteins for @entity0 , before and during treatment.

title: [Epidermal growth factor receptors: status evaluation methods and XXXX expression].

answer: @entity1


abstract: Acute @entity5 in @entity0 has been associated with @entity7 as well as with @entity2 due to @entity3 . In the United States, the incidence of @entity5 due to @entity3 appears to be as high as, or higher than that due to adenovirus type 11, but few studies are available. We studied 14 episodes of @entity5 in 13 @entity0 aged 2-14 years (mean 6.2). Ten were female. Gross @entity4 lasted 1-9 days (mean 2.2). Urine cultures were positive (greater than 10(5) colonies/ml) in 6 episodes (43%). One additional @entity0 had a suspected @entity1 . All @entity0 grew @entity3 . @entity6 was present in 78.5% but did not correlate with positive cultures. IVP was normal in 82%. @entity3 appears to be a much more common cause of @entity5 in @entity0 than heretofore reported.

title: Acute @entity5 due to XXXX .

answer: @entity3


abstract: Acute @entity5 in @entity0 has been associated with @entity7 as well as with @entity2 due to @entity3 . In the United States, the incidence of @entity5 due to @entity3 appears to be as high as, or higher than that due to adenovirus type 11, but few studies are available. We studied 14 episodes of @entity5 in 13 @entity0 aged 2-14 years (mean 6.2). Ten were female. Gross @entity4 lasted 1-9 days (mean 2.2). Urine cultures were positive (greater than 10(5) colonies/ml) in 6 episodes (43%). One additional @entity0 had a suspected @entity1 . All @entity0 grew @entity3 . @entity6 was present in 78.5% but did not correlate with positive cultures. IVP was normal in 82%. @entity3 appears to be a much more common cause of @entity5 in @entity0 than heretofore reported.

title: Acute XXXX due to @entity3 .

answer: @entity5


abstract: @entity5 ( @entity5 ) is a member of the @entity2 protein family ( @entity5 ). It responds to thermal stress in cultured glial cells. To our knowledge. nothing is known about the expression and response of the @entity5 in @entity3 . Therefore, we show here the induction of @entity5 in the brain of @entity0 after global @entity3 . @entity5 -like immunoreactivity was detected at 12, 24, and 48 hours after @entity1 recirculation. The @entity5 -like immunoreactive cells were observed in astrocytes in the hippocampal dentate gyrus and @entity4 . The peak level of @entity5 -like immunoreactivity was found 48 hours after the recirculation. @entity5 -like immunoreactivity was observed in GFAP-positive astrocytes by use of a double immunostaining method. These results provide direct evidence for the induction and localization of @entity5 immunoreactivity in vivo in a @entity0 @entity3 . We suggest that @entity5 , produced in astrocytes after @entity1 -recirculation, may directly affect neurons to protect from cell death.

title: Hippocampal heme oxigenase-1 in a XXXX cardiac arrest model.

answer: @entity0


abstract: It is well known that in @entity0 with communicating @entity2 or normal pressure @entity2 , ventricular volume decreases following implantation of differential pressure valved shunts. @entity1 (Miethke dual-switch valves) were implanted in 60 normal pressure @entity2 @entity0 at Unfallkrankenhaus Berlin between September 1997 and September 2001. One year postoperatively, these @entity0 underwent CT scan, and their ventricular size was ascertained using the Evans index. Although 77% of these @entity0 showed no postoperative change in ventricular volume, 65% nonetheless showed good to excellent clinical improvement, 13% satisfactory improvement and 22% no improvement. A moderate reduction in ventricular size was observed in 17% of the @entity0 in our cohort. 40% of these @entity0 showed good to excellent clinical improvement, 20% satisfactory improvement, and 40% unsatisfactory improvement. A marked reduction in ventricular size was observed in 6% of our @entity0 . Of these latter @entity0 , 50% showed good to excellent outcomes, while 50% had unsatisfactory outcomes. The favorable outcomes following implantation of a hydrostatic shunt in @entity0 with normal pressure @entity2 did not correlate with decreased ventricular volume one year after operation. Better clinical outcomes were observed in @entity0 with little or no alteration in ventricular size than in @entity0 with a marked decrease in ventricular size. Postoperative change in ventricular volume should be assessed differently for @entity0 with normal pressure @entity2 than in @entity0 with hypertensive @entity2 .

title: Is decreased ventricular volume a correlate of positive clinical outcome following shunt placement in cases of normal pressure XXXX ?

answer: @entity2


abstract: 45 @entity0 were treated by combined application of antilymphocyte serum, @entity4 and @entity3 : a control group of such 22 @entity0 was besides treated by @entity4 and @entity3 only. The treatment by antilymphocyte serum included a four weeks initial treatment, and one year continuous treatment one infusion per week. @entity4 and @entity3 were given every day during the same time. @entity4 only was given during the three following year. The two groups were followed up during four years. This treatment was well accepted by @entity0 under strict technical survey conditions. Serum sickness was noted in 11 p. cent of the cases. The equine antiglobulin antibody titre, increased during the initial treatment, was connected with serum sickness or, when the treatment was continued, with the inefficacy of the treatment. Rosettes titre decreased in ten cases, no clinical correlation was possible. The complement, immune complexes, were normal before treatment with most of the observed @entity0 . The delayed @entity2 skin tests were negative after a month in 80 p. cent of the cases. The cerebrospinal fluid analysis, for the elements as well as for the rate of proteins and gammaglobulins, showed no significant variations before and after the treatment. The comparison with the control group showed a significant statistical difference as too the number of aggravated and improved @entity0 after the first year. When grouping together stable and improved @entity0 , the difference was statistically significant after the third year. The difference was not significant in years "two" or four. No difference in the frequency of the relapses could be noted, in the first year or the following three years. In spite of inconsistent results comparison showed favorable data after three years. The good results seemed due to the additional use of antilymphocyte serum. Such a treatment associating antilymphocyte serum to @entity4 and @entity3 is beneficial in evolutive, remittent and recent @entity1 . Through the length of the treatment remains difficult to determine, we conclude that it is really beneficial for such @entity0 .

title: [Treatment of progressive and severe forms of @entity1 using a combination of antilymphocyte serum, @entity4 and XXXX . Clinical and biological results. Comparison with a control group treated with @entity4 and @entity3 only. 4-year follow-up].

answer: @entity3


abstract: 45 @entity0 were treated by combined application of antilymphocyte serum, @entity4 and @entity3 : a control group of such 22 @entity0 was besides treated by @entity4 and @entity3 only. The treatment by antilymphocyte serum included a four weeks initial treatment, and one year continuous treatment one infusion per week. @entity4 and @entity3 were given every day during the same time. @entity4 only was given during the three following year. The two groups were followed up during four years. This treatment was well accepted by @entity0 under strict technical survey conditions. Serum sickness was noted in 11 p. cent of the cases. The equine antiglobulin antibody titre, increased during the initial treatment, was connected with serum sickness or, when the treatment was continued, with the inefficacy of the treatment. Rosettes titre decreased in ten cases, no clinical correlation was possible. The complement, immune complexes, were normal before treatment with most of the observed @entity0 . The delayed @entity2 skin tests were negative after a month in 80 p. cent of the cases. The cerebrospinal fluid analysis, for the elements as well as for the rate of proteins and gammaglobulins, showed no significant variations before and after the treatment. The comparison with the control group showed a significant statistical difference as too the number of aggravated and improved @entity0 after the first year. When grouping together stable and improved @entity0 , the difference was statistically significant after the third year. The difference was not significant in years "two" or four. No difference in the frequency of the relapses could be noted, in the first year or the following three years. In spite of inconsistent results comparison showed favorable data after three years. The good results seemed due to the additional use of antilymphocyte serum. Such a treatment associating antilymphocyte serum to @entity4 and @entity3 is beneficial in evolutive, remittent and recent @entity1 . Through the length of the treatment remains difficult to determine, we conclude that it is really beneficial for such @entity0 .

title: [Treatment of progressive and severe forms of @entity1 using a combination of antilymphocyte serum, @entity4 and @entity3 . Clinical and biological results. Comparison with a control group treated with @entity4 and XXXX only. 4-year follow-up].

answer: @entity3


abstract: 45 @entity0 were treated by combined application of antilymphocyte serum, @entity4 and @entity3 : a control group of such 22 @entity0 was besides treated by @entity4 and @entity3 only. The treatment by antilymphocyte serum included a four weeks initial treatment, and one year continuous treatment one infusion per week. @entity4 and @entity3 were given every day during the same time. @entity4 only was given during the three following year. The two groups were followed up during four years. This treatment was well accepted by @entity0 under strict technical survey conditions. Serum sickness was noted in 11 p. cent of the cases. The equine antiglobulin antibody titre, increased during the initial treatment, was connected with serum sickness or, when the treatment was continued, with the inefficacy of the treatment. Rosettes titre decreased in ten cases, no clinical correlation was possible. The complement, immune complexes, were normal before treatment with most of the observed @entity0 . The delayed @entity2 skin tests were negative after a month in 80 p. cent of the cases. The cerebrospinal fluid analysis, for the elements as well as for the rate of proteins and gammaglobulins, showed no significant variations before and after the treatment. The comparison with the control group showed a significant statistical difference as too the number of aggravated and improved @entity0 after the first year. When grouping together stable and improved @entity0 , the difference was statistically significant after the third year. The difference was not significant in years "two" or four. No difference in the frequency of the relapses could be noted, in the first year or the following three years. In spite of inconsistent results comparison showed favorable data after three years. The good results seemed due to the additional use of antilymphocyte serum. Such a treatment associating antilymphocyte serum to @entity4 and @entity3 is beneficial in evolutive, remittent and recent @entity1 . Through the length of the treatment remains difficult to determine, we conclude that it is really beneficial for such @entity0 .

title: [Treatment of progressive and severe forms of XXXX using a combination of antilymphocyte serum, @entity4 and @entity3 . Clinical and biological results. Comparison with a control group treated with @entity4 and @entity3 only. 4-year follow-up].

answer: @entity1


abstract: 45 @entity0 were treated by combined application of antilymphocyte serum, @entity4 and @entity3 : a control group of such 22 @entity0 was besides treated by @entity4 and @entity3 only. The treatment by antilymphocyte serum included a four weeks initial treatment, and one year continuous treatment one infusion per week. @entity4 and @entity3 were given every day during the same time. @entity4 only was given during the three following year. The two groups were followed up during four years. This treatment was well accepted by @entity0 under strict technical survey conditions. Serum sickness was noted in 11 p. cent of the cases. The equine antiglobulin antibody titre, increased during the initial treatment, was connected with serum sickness or, when the treatment was continued, with the inefficacy of the treatment. Rosettes titre decreased in ten cases, no clinical correlation was possible. The complement, immune complexes, were normal before treatment with most of the observed @entity0 . The delayed @entity2 skin tests were negative after a month in 80 p. cent of the cases. The cerebrospinal fluid analysis, for the elements as well as for the rate of proteins and gammaglobulins, showed no significant variations before and after the treatment. The comparison with the control group showed a significant statistical difference as too the number of aggravated and improved @entity0 after the first year. When grouping together stable and improved @entity0 , the difference was statistically significant after the third year. The difference was not significant in years "two" or four. No difference in the frequency of the relapses could be noted, in the first year or the following three years. In spite of inconsistent results comparison showed favorable data after three years. The good results seemed due to the additional use of antilymphocyte serum. Such a treatment associating antilymphocyte serum to @entity4 and @entity3 is beneficial in evolutive, remittent and recent @entity1 . Through the length of the treatment remains difficult to determine, we conclude that it is really beneficial for such @entity0 .

title: [Treatment of progressive and severe forms of @entity1 using a combination of antilymphocyte serum, XXXX and @entity3 . Clinical and biological results. Comparison with a control group treated with @entity4 and @entity3 only. 4-year follow-up].

answer: @entity4