abstract: The purpose of this study was to determine the course of cutaneous @entity1 in a population of 362 @entity0 examined in a pediatric dermatology unit from 1975 to 1982. 461 @entity4 were observed in these @entity0 : 110 were of the naevus flammaeus type (port wine stain) including 23 forehead salmon patches. 351 were @entity1 ( @entity1 )--strawberry @entity4 . 3.5 p. 100 of @entity0 were afflicted of two types of @entity4 . Results concerning the 282 @entity0 with 351 @entity1 are detailed as followed: average follow-up: 2 years; sex-ratio M/S 1.9, most of them Caucasians. Prematurity (data obtained prospectively during 1982): 19 p. 100; clinical features: dermal: 253, subcutaneous: 35, mixed pattern 63; 2 @entity1 or more were detected in 12 p. 100 of the @entity0 ; site: head and neck; 49 p. 100, trunk: 21 p. 100, upper limbs: 14.5 lower limbs: 12 p. 100, genitals 3.5 p. 100; maximal size during follow-up: less than 1 cm: 36 p. 100, between 1 and 3 cm: 43 p. 100, more than 3 cm; 21 p. 100; time of onset: 51 p. 100 were noted at birth, 35 p. 100 during the first month, 13 p. 100 after the first month. Course of untreated @entity1 is shown in figure 1. At the end of follow-up, spontaneous evolution in 52 @entity0 was judged; very good in 44 p. 100, good in 41 p. 100, poor or bad in 15 p. 100. Minor complications ( @entity3 , infection, @entity2 ) were observed in 12.8 p. 100. Functional impairment requiring therapy was present in 2/4 plantar @entity1 , 3/30 eyelid @entity1 , 3/3 @entity1 with laryngeal involvement.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Immature XXXX . Epidemiologic study of 351 cases].

answer: @entity4


abstract: Today, by injecting @entity3 based nanoparticles (USPIO) as MRI contrast agents, it is possible to study lymphatic system and some specific @entity1 and their @entity0 . The type of surface coating, and coating characteristics of the nanoparticles are important factors for the biological properties of nanoparticles and their destination target. On the other hand, these properties contribute to different signal intensities. This may confine application of all types of USPIO based contrast agents in routine daily experiments. In this study, the ability of detecting these particles having various sizes and coating properties was evaluated for MRI applications. Signal intensity changes after administration of these particles into tissues have been studied and their detection sensitivity was evaluated using a liver phantom and animal model ( @entity2 ). IO based nanoparticles of various sizes (8-30 nm) functionalized and coated with various surface polymers such as dextran and starch, @entity5 and @entity4 groups, and bear IO particles were used to investigate the signal changes. The optimized pulse sequences for proper demonstration of lymph nodes using these contrast agents were found (T2* FSPGR protocol with fat suppressions). A detection sensitivity of 98% was achieved in most experiments during applying a proper MR protocol. However, the type of surface coating, and coating characteristics such as thickness were shown to be essential factors for MRI signal intensity in both T1 and T2 protocols.

title: Detection sensitivity of MRI using ultra-small super paramagnetic XXXX nano-particles (USPIO) in biological tissues.

answer: @entity3


abstract: PURPOSE: Most @entity1 susceptibility genes are @entity1 suppressor genes that are biallelically inactivated in familial @entity1 through somatic deletion of the wild-type allele. Identifying the genomic losses that occur in @entity3 , particularly those that occur in @entity1 , may help localize the genes responsible for @entity3 susceptibility. EXPERIMENTAL DESIGN: Normal and neoplastic tissue DNA was isolated from fresh-frozen surgically resected tissues from 20 @entity0 with primary @entity3 (defined as having at least one first-degree relative with @entity3 ), 31 with @entity5 ( @entity4 ), and 7 with familial IPMNs using laser capture microdissection. Microdissected DNA was whole genome amplified using multiple strand displacement. Genome-wide allelotypes were determined using 391 microsatellite markers. The accuracy of microdissection and fidelity of the whole genome amplification were determined by comparing the genotypes of microdissected primary @entity3 to the genotypes of xenografts derived from these @entity1 and by comparing the results of amplified to nonamplified specimens. RESULTS: The concordance of genotypes between LCM whole genome amplified primary @entity3 and their corresponding @entity3 xenograft DNAs was 98%. Among the 20 primary familial pancreatic @entity2 , we found a high prevalence of loss of heterozygosity (LOH) with an average fractional allelic loss (FAL) of 49.9% of an aggregate of 2,378 informative markers. The level of FAL in the IPMNs (10%) was significantly lower than in the pancreatic @entity2 . The most common locus of LOH in the IPMNs was at 19p (LOH at 24% of markers). The regions of frequent allelic loss observed in the @entity3 were similar to those found in sporadic @entity3 . CONCLUSIONS: The allelic loss patterns of @entity1 and IPMNs provide clues as to the genomic locations of @entity1 suppressor genes inactivated in these @entity1 .

title: Genome-wide allelotypes of familial pancreatic XXXX and familial and @entity5 .

answer: @entity2


abstract: PURPOSE: Most @entity1 susceptibility genes are @entity1 suppressor genes that are biallelically inactivated in familial @entity1 through somatic deletion of the wild-type allele. Identifying the genomic losses that occur in @entity3 , particularly those that occur in @entity1 , may help localize the genes responsible for @entity3 susceptibility. EXPERIMENTAL DESIGN: Normal and neoplastic tissue DNA was isolated from fresh-frozen surgically resected tissues from 20 @entity0 with primary @entity3 (defined as having at least one first-degree relative with @entity3 ), 31 with @entity5 ( @entity4 ), and 7 with familial IPMNs using laser capture microdissection. Microdissected DNA was whole genome amplified using multiple strand displacement. Genome-wide allelotypes were determined using 391 microsatellite markers. The accuracy of microdissection and fidelity of the whole genome amplification were determined by comparing the genotypes of microdissected primary @entity3 to the genotypes of xenografts derived from these @entity1 and by comparing the results of amplified to nonamplified specimens. RESULTS: The concordance of genotypes between LCM whole genome amplified primary @entity3 and their corresponding @entity3 xenograft DNAs was 98%. Among the 20 primary familial pancreatic @entity2 , we found a high prevalence of loss of heterozygosity (LOH) with an average fractional allelic loss (FAL) of 49.9% of an aggregate of 2,378 informative markers. The level of FAL in the IPMNs (10%) was significantly lower than in the pancreatic @entity2 . The most common locus of LOH in the IPMNs was at 19p (LOH at 24% of markers). The regions of frequent allelic loss observed in the @entity3 were similar to those found in sporadic @entity3 . CONCLUSIONS: The allelic loss patterns of @entity1 and IPMNs provide clues as to the genomic locations of @entity1 suppressor genes inactivated in these @entity1 .

title: Genome-wide allelotypes of familial pancreatic @entity2 and familial and XXXX .

answer: @entity5


abstract: PURPOSE: We examined if supervised analysis of gene expression data from phase II studies could identify @entity2 overexpression as a predictor of response to trastuzumab. EXPERIMENTAL DESIGN: Gene expression data from 132 newly diagnosed @entity0 were used to simulate 50,000 single-agent phase II trastuzumab studies. True @entity2 amplification was assessed by fluorescence in situ hybridization. RESULTS: Only 3.67% of the simulated studies yielded @entity2 as the top predictor, >96% of the individual "studies" picked a different gene as the most predictive of trastuzumab response. @entity2 was included in the top 10 gene list 9.73% of the time. When @entity2 was a priori defined as a potential predictor, 99.6% of the simulated studies confirmed overexpression among responders. Candidate marker testing may be more efficient than de novo predictor discovery in phase II trials. We describe a tandem, two-step phase II trial design for rapid marker assessment that combines two optimal two-stage phase II trials into a single study. In the first stage, unselected @entity1 are treated, and if insufficient responses are seen, the trial remains open for marker-positive @entity1 only and a second two-stage trial commences. CONCLUSIONS: The probability of successful discovery of drug-specific pharmacogenomic response markers in a typical phase II study is small. The evaluation of predefined predictors using tandem two-step phase II design has the advantages of estimating response rates in both unselected and marker-selected @entity1 populations and allows for simultaneous screening of multiple different predictors for the same drug and several distinct predictor-drug pairs in a single, parallel multiarm trial.

title: Pharmacogenomic predictor discovery in phase II clinical trials for XXXX .

answer: @entity0


abstract: BACKGROUND: Compared with chow or a @entity1 ( @entity1 ), IV administration of a parenteral nutrition solution ( @entity2 ) impairs intestinal and respiratory mucosal immunity, resulting in cellular and immunoglobulin A (IgA) defects in the intestine and impaired respiratory antiviral and antibacterial defenses. @entity2 given intragastrically (IG- @entity2 ) impairs intestinal immunity similar to @entity2 but preserves antiviral defences and partially preserves antibacterial defenses. @entity3 ( @entity3 ) is a molecule essential for development and organization of lymphoid tissue. It controls many molecules important in mucosal immune integrity. This study examines effects of route (IV or enteral) and type ( @entity2 , @entity1 , or chow) on @entity0 intestine and lung @entity3 expression. METHODS: Forty-three @entity0 randomly received @entity2 (n = 12), IG- @entity2 (n = 11), IV saline + chow (chow; n = 11), or a @entity1 (n = 9). After 5 days of feeding, intestinal and lung samples were obtained and processed for levels of @entity3 by Western blot. RESULTS: @entity2 significantly reduced intestinal and lung @entity3 compared with @entity1 and chow. IG- @entity2 reduced @entity3 levels only in the intestine but preserved lung levels. CONCLUSIONS: Route and type of nutrition differentially influence molecular events in the intestinal and respiratory mucosal immune systems. Enteral feeding with any diet (complex or chemically defined) maintains lung @entity3 expression, whereas intestinal @entity3 levels are maintained only with CEDs (chow and @entity1 ). We hypothesize that @entity3 is responsible for the observed preservation of respiratory tract immunity with administration of a noncomplex, chemically defined enteral diet, whereas intestinal immunity is compromised with this diet.

title: Enteral feeding of a chemically defined diet preserves pulmonary immunity but not intestinal immunity: the role of XXXX .

answer: @entity3


abstract: PURPOSE: Malignant @entity8 (MPM) is a disease of increasing incidence for which treatment options are limited. This study reports the clinical efficacy data for @entity9 , a novel microtubule inhibitor, in MPM. @entity0 AND METHODS: @entity0 with a histologically confirmed diagnosis of MPM were eligible for enrollment onto this multicenter phase II trial if they had not received prior chemotherapy or radiotherapy and had measurable lesions by Response Evaluation Criteria in @entity1 (RECIST) criteria. @entity9 320 mg/m2 by 10-minute intravenous infusion was administered on day 1 of 21-day cycles. Modifications of dose and schedule were made according to National @entity1 Institute Common @entity2 Criteria version 2.0. Efficacy was assessed by an external, independent radiologist. The one-sample multiple testing procedure of Fleming was applied at the predetermined recruitment stages of 20 and 40 assessable @entity0 . RESULTS: Sixty-seven @entity0 were enrolled. Five @entity0 were not assessable for @entity1 response. The response rate was 13.8% (95% CI, 6.5% to 24.7%). The median survival was 10.8 months (95% CI, 7.8 to 12.0 months). The most common adverse events were @entity4 , @entity7 , @entity6 , @entity5 , and @entity3 . Of grade 3 and 4 @entity2 , @entity7 and @entity5 were the most common (45% and 9% of @entity0 , respectively). CONCLUSION: @entity9 can be delivered with high-dose intensity in @entity0 with MPM. The response rate and median survival are encouraging for a single agent. These data suggest that @entity9 should be further evaluated in the management of MPM.

title: Phase II study of XXXX in malignant @entity8 .

answer: @entity9


abstract: PURPOSE: Malignant @entity8 (MPM) is a disease of increasing incidence for which treatment options are limited. This study reports the clinical efficacy data for @entity9 , a novel microtubule inhibitor, in MPM. @entity0 AND METHODS: @entity0 with a histologically confirmed diagnosis of MPM were eligible for enrollment onto this multicenter phase II trial if they had not received prior chemotherapy or radiotherapy and had measurable lesions by Response Evaluation Criteria in @entity1 (RECIST) criteria. @entity9 320 mg/m2 by 10-minute intravenous infusion was administered on day 1 of 21-day cycles. Modifications of dose and schedule were made according to National @entity1 Institute Common @entity2 Criteria version 2.0. Efficacy was assessed by an external, independent radiologist. The one-sample multiple testing procedure of Fleming was applied at the predetermined recruitment stages of 20 and 40 assessable @entity0 . RESULTS: Sixty-seven @entity0 were enrolled. Five @entity0 were not assessable for @entity1 response. The response rate was 13.8% (95% CI, 6.5% to 24.7%). The median survival was 10.8 months (95% CI, 7.8 to 12.0 months). The most common adverse events were @entity4 , @entity7 , @entity6 , @entity5 , and @entity3 . Of grade 3 and 4 @entity2 , @entity7 and @entity5 were the most common (45% and 9% of @entity0 , respectively). CONCLUSION: @entity9 can be delivered with high-dose intensity in @entity0 with MPM. The response rate and median survival are encouraging for a single agent. These data suggest that @entity9 should be further evaluated in the management of MPM.

title: Phase II study of @entity9 in malignant XXXX .

answer: @entity8


abstract: Age-related muscle weakening may ultimately result in the transition from an independent to a dependent life-style. The decline in muscle strength is larger than expected from the loss of muscle mass. Single fibre studies and in vitro motility assays indicate that part of the @entity2 is due to modifications of the @entity3 molecule. A lower rate of protein turnover may increase the chance of post-translational modifications such as oxidation and glycation. The impaired regenerative capacity of old muscles is related to a lower differentiation capacity of myosatellite cells, which is most likely due to altered transcriptional activity of myogenic regulatory factors (MRFs). However, old myosatellite cells can be rejuvenated when exposed to serum from young individuals. This indicates that alterations in the environment of the satellite cells or circulating substances play an important role in impaired differentiation capacity of satellite cells in old age. It is proposed that systemic @entity0 may be that factor. Indeed, the inflammatory cytokine tumour @entity1 factor-alpha: 1) impairs transcriptional regulation by MRFs, 2) suppresses myosatellite cell differentiation and 3) induces apoptosis. Moreover, muscle mass, strength and the response to strength training in old age are all inversely related to the degree of systemic @entity0 .

title: Age-related skeletal XXXX : causes and mechanisms.

answer: @entity2


abstract: AIM: To evaluate the effects of @entity3 treatment on endostatin production in @entity0 /reperfusion-injured @entity1 retinas. METHODS: Control, @entity0 , @entity3 / @entity0 groups including 7 animals in each were formed from pigmented male @entity1 . @entity2 was induced by cannulating anterior chambers and lifting the bottle to a height of 205 cm for 90 min in the @entity0 and @entity3 / @entity0 groups. The @entity3 / @entity0 group received @entity3 (300 mg/kg/day) via nasogastric tube 24 h before @entity0 and during 7 days of reperfusion. @entity1 were sacrified for biochemical analysis of retinal endostatin level by ELISA. RESULTS: The mean retinal endostatin levels of the control, @entity0 and @entity3 / @entity0 groups were 11.79 +/- 7.36, 14.70 +/- 4.88, 30.94 +/- 15.59 ng/ml, respectively. The mean retinal endostatin level of the @entity3 / @entity0 group was significantly higher than that of the control group (p = 0.011). The mean retinal endostatin level of the @entity3 / @entity0 group was higher than that of the @entity0 group, but there was no statistically significant difference (p = 0.073). No statistically significant difference in the mean retinal endostatin level was found between the control and @entity0 groups (p = 0.165). CONCLUSION: @entity3 treatment increased retinal endostatin level in @entity0 /reperfusion-injured @entity1 retinas.

title: Effect of XXXX on endostatin levels in @entity2 /reperfusion injury.

answer: @entity3


abstract: AIM: To evaluate the effects of @entity3 treatment on endostatin production in @entity0 /reperfusion-injured @entity1 retinas. METHODS: Control, @entity0 , @entity3 / @entity0 groups including 7 animals in each were formed from pigmented male @entity1 . @entity2 was induced by cannulating anterior chambers and lifting the bottle to a height of 205 cm for 90 min in the @entity0 and @entity3 / @entity0 groups. The @entity3 / @entity0 group received @entity3 (300 mg/kg/day) via nasogastric tube 24 h before @entity0 and during 7 days of reperfusion. @entity1 were sacrified for biochemical analysis of retinal endostatin level by ELISA. RESULTS: The mean retinal endostatin levels of the control, @entity0 and @entity3 / @entity0 groups were 11.79 +/- 7.36, 14.70 +/- 4.88, 30.94 +/- 15.59 ng/ml, respectively. The mean retinal endostatin level of the @entity3 / @entity0 group was significantly higher than that of the control group (p = 0.011). The mean retinal endostatin level of the @entity3 / @entity0 group was higher than that of the @entity0 group, but there was no statistically significant difference (p = 0.073). No statistically significant difference in the mean retinal endostatin level was found between the control and @entity0 groups (p = 0.165). CONCLUSION: @entity3 treatment increased retinal endostatin level in @entity0 /reperfusion-injured @entity1 retinas.

title: Effect of @entity3 on endostatin levels in XXXX /reperfusion injury.

answer: @entity2


abstract: The optimal treatment of @entity0 with @entity3 , such as @entity2 , depends on the accurate diagnosis by using a combination of clinical and histopathological data. In many scenarios, it becomes tremendously difficult because of the limitations in clinical presentation and histopathology. To accurate diagnose @entity3 , the molecular classification based on gene or protein expression profiles are indispensable for modern medicine. Moreover, many @entity3 consist of various potential subtypes in molecular basis and differ remarkably in their response to therapies. It is critical to accurate predict subgroup on disease gene expression profiles. More fundamental knowledge of the molecular basis and classification of disease could aid in the prediction of @entity0 outcome, the informed selection of therapies, and identification of novel molecular targets for therapy. In this paper, we propose a new disease diagnostic method, probabilistic boosting tree (PB tree) method, on gene expression profiles of @entity1 . It enables accurate disease classification and subtype discovery in disease. It automatically constructs a tree in which each node combines a number of weak classifiers into a strong classifier. Also, subtype discovery is naturally embedded in the learning process. Our algorithm achieves excellent diagnostic performance, and meanwhile it is capable of detecting the disease subtype based on gene expression profile.

title: XXXX diagnosis and subtype discovery by gene expression profiling.

answer: @entity1


abstract: This report describes the selection and behavior of @entity1 cells resistant to cytolysis by syngeneic lymphocytes. Two B16 melanoma lines, F1 (low metastasis) and @entity4 (high metastasis), were cultured with lymphocytes from C57BL/6 @entity2 immunized against B16. The selection procedure involved repeated exposure of the @entity1 cells to lymphocytes in vitro. After each interaction, the viable @entity1 cells were trpsinized, replated, and designated lines F1Lr-1 and F10Lr-1. The procedure was repeated five times, yielding lines F1Lr-6 and F10Lr-6, which resisted cytolysis by syngeneic lymphocytes. @entity2 were given s.c. or i.v. injections of cells from lines F1, F1Lr-6, @entity4 , or F10Lr-6. Tumor growth patterns were the same for all four lines when the cells were injected s.c., however, the incidence of @entity3 differed significantly after i.v. injection. Line @entity4 cells yielded more @entity3 than an equal number of line F1 cells (p less than 0.01). F1Lr-6 cells yielded significantly fewer @entity0 than an equal number of lines F1 cells (p less than 0.01). A similar difference between F10Lr-6 and @entity4 cells was observed. The incidence of artificial @entity0 after i.v. injection of F10Lr-6 cells was similar to that for F1 cells. The quantitative organ distribution, arrest, and survival of i.v.-injected @entity1 cells were studied by using [125]-5-iodo-2'-deoxyuridinelabeled cells. There was a significantly greater number of cells from line @entity4 , arrested and able to survive for 14 days in lungs, than cells from line F1. In contrast, cells from either line F1Lr-6 or F10Lr-6 had a lower incidence of arrest and survival than their lymphocyte-sensitive counterparts.

title: Characterization in vivo and in vitro of XXXX cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity.

answer: @entity1


abstract: Gene therapy is one of the most important aspects of molecular targeted therapeutic approaches for @entity2 . A small molecule targeting carrier plays an important role in this process. PI, a new peptide found in our phage library, has been specifically suggested, combined with the @entity1 triple-negative @entity0 cell line MDA-MB  -231, and may be developed as a targeting/individualization therapy strategy to be applied in @entity0 research. In this study, we further investigated whether this peptide could carry exogenous protein to the target cells by forming a fusion peptide. PI-GST and PI-TK were cloned into plasmids and used for expression studies, analyses of PI-mediated protein delivery efficiency, and to investigations into the effect of PI on @entity4 kinase/ @entity5 -mediated @entity3 . Biodistribution profiles were also investigated in vivo. The results showed the PI fusion protein was expressed correctly in vitro, and could carry GST into the target cells. Under certain conditions, PI-TK sensitizes cells to @entity5 more efficiently than TK. In vivo there was a trend for increased inhibition of @entity2 growth with PI-TK when @entity5 was present. Therefore, our results suggest the potential of PI as a new specific target carrier in @entity0 therapy.

title: Characterization of PI ( XXXX cell special peptide) in MDA-MB-231 @entity0 cells and its potential therapeutic applications.

answer: @entity0


abstract: Gene therapy is one of the most important aspects of molecular targeted therapeutic approaches for @entity2 . A small molecule targeting carrier plays an important role in this process. PI, a new peptide found in our phage library, has been specifically suggested, combined with the @entity1 triple-negative @entity0 cell line MDA-MB  -231, and may be developed as a targeting/individualization therapy strategy to be applied in @entity0 research. In this study, we further investigated whether this peptide could carry exogenous protein to the target cells by forming a fusion peptide. PI-GST and PI-TK were cloned into plasmids and used for expression studies, analyses of PI-mediated protein delivery efficiency, and to investigations into the effect of PI on @entity4 kinase/ @entity5 -mediated @entity3 . Biodistribution profiles were also investigated in vivo. The results showed the PI fusion protein was expressed correctly in vitro, and could carry GST into the target cells. Under certain conditions, PI-TK sensitizes cells to @entity5 more efficiently than TK. In vivo there was a trend for increased inhibition of @entity2 growth with PI-TK when @entity5 was present. Therefore, our results suggest the potential of PI as a new specific target carrier in @entity0 therapy.

title: Characterization of PI ( @entity0 cell special peptide) in MDA-MB-231 XXXX cells and its potential therapeutic applications.

answer: @entity0


abstract: UNASSIGNED: Engulfment of the forespore by the mother cell is a universal feature of endosporulation. In @entity3 , the forespore protein SpoIIQ and the mother cell protein SpoIIIAH form a channel, essential for endosporulation through which the developing spore is nurtured. The two proteins also form a backup system for engulfment. Unlike in @entity3 , SpoIIQ of @entity1 has intact LytM @entity0 -binding motifs. We show that spoIIQ or spoIIIAH deletion mutants of @entity1 result in anomalous engulfment, and that disruption of the SpoIIQ LytM domain via a single @entity2 substitution ( @entity5 ) impairs engulfment differently. SpoIIQ and SpoIIQ( @entity5 ) interact with SpoIIIAH throughout engulfment. SpoIIQ, but not SpoIIQ( @entity5 ) , binds @entity4 , and metal absence alters the SpoIIQ-SpoIIIAH complex in vitro. Possibly, SpoIIQ( @entity5 ) supports normal engulfment in some cells but not a second function of the complex, required following engulfment completion. We show that cells of the spoIIQ or spoIIIAH mutants that complete engulfment are impaired in post-engulfment, forespore and mother cell-specific gene expression, suggesting a channel-like function. Both engulfment and a channel-like function may be ancestral functions of SpoIIQ-SpoIIIAH while the requirement for engulfment was alleviated through the emergence of redundant mechanisms in @entity3 and related organisms. This article is protected by copyright. All rights reserved.

title: The SpoIIQ-SpoIIIAH complex of XXXX controls forespore engulfment and late stages of gene expression and spore morphogenesis.

answer: @entity1


abstract: BACKGROUND AND STUDY AIMS: @entity4 ( @entity4 ) are a surgery-sparing option for malignant @entity3 . They can be inserted as a "bridge to surgery" (BTS) for potentially curable disease, or as a palliative measure, thereby avoiding the higher morbidity and mortality associated with surgery. The objective of this study was to report our local experience of left-sided colonic stents. METHODS: Data on 49 @entity0 was collected retrospectively from Oct 2008 to Nov 2014 at our @entity1 centre. This included demographics, baseline clinical characteristics, indications for @entity4 placement (bridge to surgery/palliative), technical and clinical success, complications, and the mean patency of duration. Survival in both groups was also plotted on a Kaplan-Meier chart. RESULTS: A total of 49 @entity0 with @entity2 ( @entity2 ) of the left side were enrolled. The mean age was 50  years (range 18-86). Ninety percent of @entity0 had disease involving the rectum, sigmoid colon, or both. Forty-seven percent (n   =   23) of @entity0 had stent insertion as a BTS, whereas 53  % (n   =   26) had the procedure with palliative intent. Technical and clinical success rates were 96  and 88  %, respectively. The clinical success rate of the palliative arm was lower than that of the BTS arm (p   =   0.024). 87.5  % (n   =   42) had no procedure-related complications. Technical failure, perforation, and stent migration/expulsion, were each observed in 4  % of cases. Mean stent patency duration was 83.9  days. CONCLUSION: @entity4 insertion for left-sided malignant @entity3 is a safe and effective procedure when used either as a bridge to surgery or with palliative intent.

title: @entity4 ( @entity4 ) in Left-Sided XXXX -a @entity1 Center Experience.

answer: @entity3


abstract: BACKGROUND AND STUDY AIMS: @entity4 ( @entity4 ) are a surgery-sparing option for malignant @entity3 . They can be inserted as a "bridge to surgery" (BTS) for potentially curable disease, or as a palliative measure, thereby avoiding the higher morbidity and mortality associated with surgery. The objective of this study was to report our local experience of left-sided colonic stents. METHODS: Data on 49 @entity0 was collected retrospectively from Oct 2008 to Nov 2014 at our @entity1 centre. This included demographics, baseline clinical characteristics, indications for @entity4 placement (bridge to surgery/palliative), technical and clinical success, complications, and the mean patency of duration. Survival in both groups was also plotted on a Kaplan-Meier chart. RESULTS: A total of 49 @entity0 with @entity2 ( @entity2 ) of the left side were enrolled. The mean age was 50  years (range 18-86). Ninety percent of @entity0 had disease involving the rectum, sigmoid colon, or both. Forty-seven percent (n   =   23) of @entity0 had stent insertion as a BTS, whereas 53  % (n   =   26) had the procedure with palliative intent. Technical and clinical success rates were 96  and 88  %, respectively. The clinical success rate of the palliative arm was lower than that of the BTS arm (p   =   0.024). 87.5  % (n   =   42) had no procedure-related complications. Technical failure, perforation, and stent migration/expulsion, were each observed in 4  % of cases. Mean stent patency duration was 83.9  days. CONCLUSION: @entity4 insertion for left-sided malignant @entity3 is a safe and effective procedure when used either as a bridge to surgery or with palliative intent.

title: XXXX ( @entity4 ) in Left-Sided @entity3 -a @entity1 Center Experience.

answer: @entity4


abstract: BACKGROUND AND STUDY AIMS: @entity4 ( @entity4 ) are a surgery-sparing option for malignant @entity3 . They can be inserted as a "bridge to surgery" (BTS) for potentially curable disease, or as a palliative measure, thereby avoiding the higher morbidity and mortality associated with surgery. The objective of this study was to report our local experience of left-sided colonic stents. METHODS: Data on 49 @entity0 was collected retrospectively from Oct 2008 to Nov 2014 at our @entity1 centre. This included demographics, baseline clinical characteristics, indications for @entity4 placement (bridge to surgery/palliative), technical and clinical success, complications, and the mean patency of duration. Survival in both groups was also plotted on a Kaplan-Meier chart. RESULTS: A total of 49 @entity0 with @entity2 ( @entity2 ) of the left side were enrolled. The mean age was 50  years (range 18-86). Ninety percent of @entity0 had disease involving the rectum, sigmoid colon, or both. Forty-seven percent (n   =   23) of @entity0 had stent insertion as a BTS, whereas 53  % (n   =   26) had the procedure with palliative intent. Technical and clinical success rates were 96  and 88  %, respectively. The clinical success rate of the palliative arm was lower than that of the BTS arm (p   =   0.024). 87.5  % (n   =   42) had no procedure-related complications. Technical failure, perforation, and stent migration/expulsion, were each observed in 4  % of cases. Mean stent patency duration was 83.9  days. CONCLUSION: @entity4 insertion for left-sided malignant @entity3 is a safe and effective procedure when used either as a bridge to surgery or with palliative intent.

title: @entity4 ( XXXX ) in Left-Sided @entity3 -a @entity1 Center Experience.

answer: @entity4


abstract: BACKGROUND AND STUDY AIMS: @entity4 ( @entity4 ) are a surgery-sparing option for malignant @entity3 . They can be inserted as a "bridge to surgery" (BTS) for potentially curable disease, or as a palliative measure, thereby avoiding the higher morbidity and mortality associated with surgery. The objective of this study was to report our local experience of left-sided colonic stents. METHODS: Data on 49 @entity0 was collected retrospectively from Oct 2008 to Nov 2014 at our @entity1 centre. This included demographics, baseline clinical characteristics, indications for @entity4 placement (bridge to surgery/palliative), technical and clinical success, complications, and the mean patency of duration. Survival in both groups was also plotted on a Kaplan-Meier chart. RESULTS: A total of 49 @entity0 with @entity2 ( @entity2 ) of the left side were enrolled. The mean age was 50  years (range 18-86). Ninety percent of @entity0 had disease involving the rectum, sigmoid colon, or both. Forty-seven percent (n   =   23) of @entity0 had stent insertion as a BTS, whereas 53  % (n   =   26) had the procedure with palliative intent. Technical and clinical success rates were 96  and 88  %, respectively. The clinical success rate of the palliative arm was lower than that of the BTS arm (p   =   0.024). 87.5  % (n   =   42) had no procedure-related complications. Technical failure, perforation, and stent migration/expulsion, were each observed in 4  % of cases. Mean stent patency duration was 83.9  days. CONCLUSION: @entity4 insertion for left-sided malignant @entity3 is a safe and effective procedure when used either as a bridge to surgery or with palliative intent.

title: @entity4 ( @entity4 ) in Left-Sided @entity3 -a XXXX Center Experience.

answer: @entity1


abstract: The purpose of this study was to evaluate the effect of different cooking methods on the allergenicity of cockle and to identify proteins most frequently bound by IgE antibodies using a proteomics approach. Raw, boiled, fried and roasted extracts of the cockle were prepared. The protein profiles of the extracts were obtained by separation using @entity2 - @entity5 gel electrophoresis ( @entity2 -PAGE) and 2-dimensional gel electrophoresis (2-DE). IgE-immunoblotting was then performed with the use of individual sera from @entity0 with @entity4 and the major IgE-binding proteins were analyzed by mass-spectrometry. @entity2 -PAGE of raw extract showed 13 protein bands. Smaller numbers of protein bands were detected in the boiled, fried and roasted extracts. The 2-DE gel profile of the raw extract further separated the protein bands to ~50 protein spots with molecular masses between 13 to 180 kDa and isoelectric point (pI) values ranging from 3 to 10. Immunoblotting of raw extract exhibited 11 IgE-binding proteins with two proteins of 36 and 40 kDa as the major IgE-binding proteins, while the boiled extract revealed 3 IgE-binding proteins. Fried and roasted extracts only showed a single IgE-binding protein at 36 kDa. 2-DE immunoblotting of raw extract demonstrated 5 to 20 IgE reactive spots. Mass spectrometry analysis led to identification of 2 important allergens, tropomyosin (36 kDa) and @entity3 kinase (40 kDa). Heated extracts showed a reduction in the number of IgE-reactive bands compared with raw extract, which suggest that thermal treatment can be used as a tool in attempting to reduce cockle allergenicity. The degree of allergenicity of cockle was demonstrated in the order raw > boiled > fried     roasted. Two important allergens reacting with more than 50% of @entity0 ' sera identified using mass spectrometric approaches were tropomyosin and @entity3 kinase. Thus, allergens found in this study would help in component based diagnosis, management of @entity1 @entity0 and to the standardisation of allergenic test products as tools in molecular allergology.

title: Malaysian cockle (Anadara granosa) XXXX : Identification of IgE-binding proteins and effects of different cooking methods.

answer: @entity4


abstract: OBJECTIVE: To observe the peripheral retinal changes of anterior @entity4 @entity0 using ultra-wide field fluorescein angiography. METHODS: Retrospective case series study. Thirty-three eyes of 20 @entity0 diagnosed as anterior @entity4 from September to November 2013 in the ophthalmic clinic of Peking University First Hospital was included. All the @entity0 underwent routine ocular examination, followed by ultra-wide field Fluorescein. RESULTS: There were 13 male @entity0 and 7 female @entity0 , aged 23-66, an average of 46 years old. The anterior @entity4 recurrent in both eyes in 13 @entity0 and only one eye in 7 @entity0 . @entity4 duration ranging from months to 30 years. Twenty eyes were at the active stage of the anterior @entity4 while 13 eyes in the quiescent stage. @entity2 was detected in 57.6% (19/33) of the eyes, among which in eyes with @entity2 was 75% (15/20), and in eyes with quiescent disease the rate was 30.8% (4/13). Optic disk hyperfluorescence was found in 6 of 20 eyes with active disease. @entity3 was found in 4 eyes. In addition, peripheral retinal hyperfluorescence dot and zone were detected in 2 eyes. CONCLUSIONS: Peripheral retinal vessels were detected to have inflammative leakage in @entity0 of anterior @entity4 by ultra-wide field @entity1 agiography. @entity2 may still exist even in the quiescent stage of the anterior @entity4 .

title: [The clinical investigation of peripheral retinal changes of anterior XXXX ].

answer: @entity4


abstract: @entity5 is an @entity2 which involves the uvea, retina, retinal vessel and vitreous body. The disease mainly affects middle age and young @entity0 with a variety of clinical manifestations and is often recurrent. If not treated properly, it will cause @entity3 and even @entity6 . Spectral domain optical coherence tomography (SD- @entity7 ) is a noninvasive examination which provides clear images quickly without contacting the eyes. As the development of @entity7 , we can obtain the sectional images with similar resolution as histological examination. Especially, when the enhanced depth image @entity7 (EDI- @entity7 ) was used in clinical, the structures of choroid could also be detected. Therefore, @entity7 was used more and more in @entity5 @entity0 . Anterior segment @entity7 (AS- @entity7 ) is used to evaluate the @entity2 in anterior chamber. It also can provide the changes of iris and corneal structures during acute phase and recovery period. SD- @entity7 can clearly display many kinds of @entity4 in @entity0 with @entity5 including macular @entity1 and the changes of retinal thickness. EDI- @entity7 can be used to observe the changes of retina and choroid at the same time. In particular, the measurement of choroidal thickness can be used to evaluate the choroidal changes and the degree of the response to treatment. Therefore, SD- @entity7 helps to diagnose @entity5 and is easily used in the disease follow-up and treatment effect observation.

title: [The application of optical coherence tomography in XXXX @entity0 ].

answer: @entity5


abstract: @entity5 is an @entity2 which involves the uvea, retina, retinal vessel and vitreous body. The disease mainly affects middle age and young @entity0 with a variety of clinical manifestations and is often recurrent. If not treated properly, it will cause @entity3 and even @entity6 . Spectral domain optical coherence tomography (SD- @entity7 ) is a noninvasive examination which provides clear images quickly without contacting the eyes. As the development of @entity7 , we can obtain the sectional images with similar resolution as histological examination. Especially, when the enhanced depth image @entity7 (EDI- @entity7 ) was used in clinical, the structures of choroid could also be detected. Therefore, @entity7 was used more and more in @entity5 @entity0 . Anterior segment @entity7 (AS- @entity7 ) is used to evaluate the @entity2 in anterior chamber. It also can provide the changes of iris and corneal structures during acute phase and recovery period. SD- @entity7 can clearly display many kinds of @entity4 in @entity0 with @entity5 including macular @entity1 and the changes of retinal thickness. EDI- @entity7 can be used to observe the changes of retina and choroid at the same time. In particular, the measurement of choroidal thickness can be used to evaluate the choroidal changes and the degree of the response to treatment. Therefore, SD- @entity7 helps to diagnose @entity5 and is easily used in the disease follow-up and treatment effect observation.

title: [The application of optical coherence tomography in @entity5 XXXX ].

answer: @entity0


abstract: UNASSIGNED: This randomized, multicenter study compared the relative efficacy of renal denervation (RDN) versus pharmacotherapy alone in @entity0 with true resistant @entity1 and assessed the effect of @entity2 addition. We present here the 12-month data. A total of 106 @entity0 with true resistant @entity1 were enrolled in this study: 52 @entity0 were randomized to RDN and 54 @entity0 to the @entity2 addition, with baseline systolic blood pressure of 159  17 and 155  17 mm Hg and average number of drugs 5.1 and 5.4, respectively. Twelve-month results are available in 101 @entity0 . The intention-to-treat analysis found a comparable mean 24-hour systolic blood pressure decline of 6.4 mm Hg, P=0.001 in RDN versus 8.2 mm Hg, P=0.002 in the pharmacotherapy group. Per-protocol analysis revealed a significant difference of 24-hour systolic blood pressure decline between complete RDN (6.3 mm Hg, P=0.004) and the subgroup where @entity2 was added, and this continued within the 12 months (15 mm Hg, P= 0.003). Renal artery computed tomography angiograms before and after 1 year post-RDN did not reveal any relevant changes. This study shows that over a period of 12 months, RDN is safe, with no serious side effects and no major changes in the renal arteries. RDN in the settings of true resistant @entity1 with confirmed compliance is not superior to intensified pharmacological treatment. @entity2 addition (if tolerated) seems to be more effective in blood pressure reduction.

title: Role of Adding @entity2 and Renal Denervation in True Resistant XXXX : One-Year Outcomes of Randomized PRAGUE-15 Study.

answer: @entity1


abstract: UNASSIGNED: This randomized, multicenter study compared the relative efficacy of renal denervation (RDN) versus pharmacotherapy alone in @entity0 with true resistant @entity1 and assessed the effect of @entity2 addition. We present here the 12-month data. A total of 106 @entity0 with true resistant @entity1 were enrolled in this study: 52 @entity0 were randomized to RDN and 54 @entity0 to the @entity2 addition, with baseline systolic blood pressure of 159  17 and 155  17 mm Hg and average number of drugs 5.1 and 5.4, respectively. Twelve-month results are available in 101 @entity0 . The intention-to-treat analysis found a comparable mean 24-hour systolic blood pressure decline of 6.4 mm Hg, P=0.001 in RDN versus 8.2 mm Hg, P=0.002 in the pharmacotherapy group. Per-protocol analysis revealed a significant difference of 24-hour systolic blood pressure decline between complete RDN (6.3 mm Hg, P=0.004) and the subgroup where @entity2 was added, and this continued within the 12 months (15 mm Hg, P= 0.003). Renal artery computed tomography angiograms before and after 1 year post-RDN did not reveal any relevant changes. This study shows that over a period of 12 months, RDN is safe, with no serious side effects and no major changes in the renal arteries. RDN in the settings of true resistant @entity1 with confirmed compliance is not superior to intensified pharmacological treatment. @entity2 addition (if tolerated) seems to be more effective in blood pressure reduction.

title: Role of Adding XXXX and Renal Denervation in True Resistant @entity1 : One-Year Outcomes of Randomized PRAGUE-15 Study.

answer: @entity2


abstract: UNASSIGNED: @entity6 and tracheobronchitis are diagnosed frequently following lung transplantation. The diseases share clinical signs of @entity0 and are often difficult to differentiate based on culture results. Microbiome and host immune response signatures that distinguish between @entity1 and tracheobronchitis are undefined. Using a retrospective study design, we selected 49 bronchoalveolar lavage fluid samples from 16 lung transplant recipients diagnosed with @entity1 (n=8), tracheobronchitis (n=12) or colonization without @entity5 (n=29). We ensured an even distribution of @entity4 or @entity3 culture-positive samples across the groups. Bayesian regression analysis identified non-culture based signatures comprising 16S rRNA microbiome profiles, cytokine levels, and clinical variables that characterized the three diagnoses. Relative to samples associated with colonization, those from @entity1 had significantly lower microbial diversity, decreased levels of several bacterial genera, and prominent multifunctional cytokine responses. In contrast, tracheobronchitis was characterized by high microbial diversity and multifunctional cytokine responses that differed from those of @entity2 comparisons. The dissimilar microbiomes and cytokine responses underlying @entity6 and tracheobronchitis following lung transplantation suggest that the diseases result from different pathogenic processes. Microbiomes and cytokine responses had complementary features, suggesting that they are closely inter-connected in the pathogenesis of both diseases. This article is protected by copyright. All rights reserved.

title: Looking beyond respiratory cultures: Microbiome-cytokine signatures of XXXX and tracheobronchitis in lung transplant recipients.

answer: @entity6


abstract: UNASSIGNED: Transcatheter MitraClip repair is a new tool for the management of severe @entity1 in @entity0 at very high risk for conventional surgery. Aim of our study was reporting one-year clinical outcomes in candidates to MitraClip procedures, divided into three groups according to the cardiovascular medicine @entity2 (CVM-HF) index. The study population consists of 46 consecutive @entity0 , divided, in accordance with CVM-HF index, as follows: one @entity0 in the low-risk category (group A); 27 @entity0 in the medium-risk (group B) and 18 @entity0 in high-risk category (group C). The primary study endpoint was a combined of all-cause mortality and re-hospitalization rate. Secondary endpoints were all-cause mortality and cardiac mortality. @entity0 of group B and group C were compared. Regarding the primary endpoint, @entity0 in group C had significantly poorer outcomes than @entity0 in group B, with a 12-month survival freedom from events of 44.4   and 74.1  %, respectively (log-rank test, p  =  0.039); survival freedom from cardiac mortality was 100 and 83.3  % in group B and C, respectively (log-rank test, p  =  0.027). One-year survival free from re-hospitalization was 74.1  % in group B and 39.9  % in group C (log-rank test; p  =  0.036). Survival free from all-cause of mortality was 92.6 and 77.8  %, respectively (log-rank test; p  =  0.129). In our initial experience the CVM-HF index showed to be valuable for understanding if the @entity0 with advanced @entity2 and functional @entity1 can really benefit by MitraClip therapy.

title: Cardiovascular medicine XXXX (CVM-HF) index as prognostic model for candidates to MitraClip therapy.

answer: @entity2


abstract: INTRODUCTION: @entity3 ( @entity3 ) is well known for its propensity to metastasize to unusual sites, even after 10 years. Gallbladder @entity1 are extremely rare, being found in approximately 0.6% of cases, at autopsy. CASE PRESENTATION: A 51-year-old @entity0 with a history of right @entity3 underwent total nephrectomy with extended lymphadenectomy, in another Hospital. Three years later, he was hospitalized at our Hospital, with gallbladder @entity1 detected during a follow-up CT scan. At clinical examination, the @entity0 did not present any symptoms or signs of @entity2 . Several imaging tests were performed to better characterize the lesion. A successful cholecystectomy and hepatic resection of 4b segment were performed, obtaining a R0 resection. The clinical course was uneventful, without any complications. After a 7-month follow-up, the @entity0 is free from disease. DISCUSSION: A typical @entity1 are those located in a site other than thoracic, skeletal, hepatic, adrenal or encephalic tissue. Cholecystectomy with R0 resection has demonstrated to be the only factor increasing survival, mainly in isolated cases of @entity1 , providing an overall 35-60% survival rate at 5 years. CONCLUSION: In the follow-up of @entity0 with a positive history of @entity3 specially clear cell subtype, all new finding should be taken into account as possible @entity1 . We ought to consider US and CT-scan behavior of gallbladder metastatic disease in order to orientate our diagnosis. Surgery for metastatic @entity2 of renal origin seems to be a feasible therapy which is capable of increasing @entity0 ' overall survival.

title: Gallbladder's XXXX @entity1 : A case report.

answer: @entity3


abstract: INTRODUCTION: @entity3 ( @entity3 ) is well known for its propensity to metastasize to unusual sites, even after 10 years. Gallbladder @entity1 are extremely rare, being found in approximately 0.6% of cases, at autopsy. CASE PRESENTATION: A 51-year-old @entity0 with a history of right @entity3 underwent total nephrectomy with extended lymphadenectomy, in another Hospital. Three years later, he was hospitalized at our Hospital, with gallbladder @entity1 detected during a follow-up CT scan. At clinical examination, the @entity0 did not present any symptoms or signs of @entity2 . Several imaging tests were performed to better characterize the lesion. A successful cholecystectomy and hepatic resection of 4b segment were performed, obtaining a R0 resection. The clinical course was uneventful, without any complications. After a 7-month follow-up, the @entity0 is free from disease. DISCUSSION: A typical @entity1 are those located in a site other than thoracic, skeletal, hepatic, adrenal or encephalic tissue. Cholecystectomy with R0 resection has demonstrated to be the only factor increasing survival, mainly in isolated cases of @entity1 , providing an overall 35-60% survival rate at 5 years. CONCLUSION: In the follow-up of @entity0 with a positive history of @entity3 specially clear cell subtype, all new finding should be taken into account as possible @entity1 . We ought to consider US and CT-scan behavior of gallbladder metastatic disease in order to orientate our diagnosis. Surgery for metastatic @entity2 of renal origin seems to be a feasible therapy which is capable of increasing @entity0 ' overall survival.

title: Gallbladder's @entity3 XXXX : A case report.

answer: @entity1


abstract: BACKGROUND: Optimal surgical treatment for @entity3 remains controversial. Studies in @entity0 are uncommon with overall high postoperative recurrence and @entity1 rates (20%). Our unit adopted a technique for excision of the @entity3 with primary midline closure using a full-thickness flap. We present our results of this technique in the pediatric age group. METHODS: Single-center retrospective review and telephone follow-up was performed, including all @entity0 undergoing @entity3 from 2005 to 2014 using the same operative technique and preoperative/postoperative care. RESULTS: 19 @entity0 were identified. Median age was 15years, and 47% were male. All had previously infected sinuses, with 5 requiring abscess drainage. Median follow-up was 13months (3.5-67months). Histology confirmed @entity3 in 18/19 cases (one developmental @entity2 excluded from subsequent analysis). Recurrence requiring further surgery occurred in 4/18 (22%) @entity0 at a median of 9months (range 8-36), wound dehiscence in 8/18 (44%), and wound @entity1 in 5/18 (28%) cases. Laser hair removal of the natal cleft was performed in 7/18 (39%) @entity0 with no further recurrence. CONCLUSION: This is the first report of this technique in @entity0 which showed a higher incidence of complications than a comparable adult study. Our study underlines the importance of accurate long-term outcomes when introducing new techniques to evaluate operation-associated morbidity. Our preliminary results of laser hair removal are promising but need to be evaluated with a prospective study.

title: Improving outcomes in XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity7 (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and @entity5 catabolism, and its accumulation is associated with various @entity2 , such as @entity0 and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocampal neurons. However, these effects have not been studied in the context of neurogenesis. Here, we report that MG adversely affects hippocampal neurogenesis and induces neural progenitor cell (NPC) @entity3 . MG significantly reduced C17.2 NPC proliferation, and high concentration of MG (500   M) induced cell @entity3 and elevated oxidative stress. Further, MG was found to activate the ERK signaling pathway, indicating elevated stress response. To determine the effects of MG in vivo, @entity1 were administrated with vehicle or MG (0.5 or 1  % in drinking water) for 4  weeks. The numbers of BrdU-positive cells in hippocampi were significantly lower in MG-treated @entity1 , indicating impaired neurogenesis, but MG did not induce @entity4 or glial activations. Interestingly, MG reduced memory retention when administered to @entity1 at 1  % but not at 0.5  %. In addition, the levels of hippocampal @entity6 and @entity8 were significantly lower in the hippocampi of @entity1 treated with MG at 1  %. Collectively, our findings suggest MG could be harmful to NPCs and to hippocampal neurogenesis.

title: XXXX Causes Cell Death in Neural Progenitor Cells and Impairs Adult Hippocampal Neurogenesis.

answer: @entity7


abstract: BACKGROUND: Vital signs play a critical role in prioritizing @entity0 in @entity3 ( @entity3 ), and are the foundation of most triage methods and disposition decisions. This study was conducted to determine the frequency of vital signs documentation anytime during emergency department treatment and to explore if abnormal vital signs were associated with the likelihood of admission for a set of common presenting complaints. METHODS: Data were collected over a four-month period from the @entity3 of seven urban tertiary care hospitals in Pakistan. The variables included age, sex, hospital type (government run vs. private), presenting complaint, @entity6 vital signs, and final disposition. @entity0 who were >12 years of age were included in the analysis. The data were analyzed to describe the proportion of @entity0 with documented vitals signs, which was then crossed-tabulated with top the ten presenting complaints to identify high-acuity @entity0 and correlation with their admission status. RESULTS: A total of 274,436 @entity0 were captured in the Pakistan National Emergency Department Surveillance (Pak-NEDS), out of which 259,288 @entity0 were included in our study. Vital signs information was available for 90,569 (34.9%) @entity0 and the most commonly recorded vitals sign was pulse (25.7%). Important information such as level of consciousness was missing in the majority of @entity0 with @entity4 . Based on available information, only 13.3% with @entity5 , 12.8% with @entity1 and 12.8% @entity0 with @entity2 could be classified as high-acuity. In addition, hospital admission rates were two- to four-times higher among @entity0 with abnormal vital signs, compared with those with normal vital signs. CONCLUSION: Most @entity0 seen in the @entity3 in Pakistan did not have any documented vital signs during their visit. Where available, the presence of abnormal vital signs were associated with higher chances of admission to the hospital for the most common presenting symptoms.

title: How vital are the vital signs? a multi-center observational study from XXXX of Pakistan.

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) has been known as a variant of exudative @entity1 ( @entity1 ) with a unfavorable prognosis. To evaluate the effect of ranibizumab administered initially as three loading doses for @entity0 with various stages of @entity2 . METHODS: A retrospective chart review of 40 @entity0 (41 eyes) with @entity2 was conducted. The study divided @entity0 into three groups of Group I (8 eyes in stage I), Group II (17eyes in stage II), and Group III (16 eyes in stage III). All @entity0 received three initial monthly intravitreal injections (0.5  mg) of ranibizumab and were monitored monthly for 12  months. Reinjection of ranibizumab after three initial monthly doses was administered on as-needed basis. The main outcome measures were the change in the mean of best-corrected Snellen visual acuity (BCVA) and @entity1 ( @entity1 ), and the total number of injections received during the 12  months. RESULTS: The mean change in BCVA at 12  months was-0.286,-0.165, and-0.151 (logMAR) in Group I, II, and III, respectively. @entity1 was also reduced by a mean of 32.72        56.75, 57.45        56.48 and 148.37        98.59   m. The mean number of injections in Group I was significant lower than those in Group II and III (P   <   0.001, P   <   0.001, and P   =   0.15 for Group I versus Group II, Group I versus Group III, and Group II versus Group III, respectively). CONCLUSIONS: The 12-month follow-up outcomes suggest that three consecutive loading doses of intravitreal ranibizumab is an effective treatment on early stage (stage I) of @entity2 . @entity0 in stage I showed a significantly lower recurrence rate than @entity0 in later stages.

title: One year results of intravitreal ranibizumab monotherapy for XXXX : a comparative analysis based on disease stages.

answer: @entity2


abstract: Electrodiagnostic (EDX) patterns of @entity3 have been based on axonal/demyelinating criteria requiring prior assumptions. This has not produced classifications of desired sensitivity or specificity. Furthermore, standard nerve conduction studies have limited reproducibility. New methodologies in EDX seem important. Recurrent Quantification Analysis (RQA) is a nonlinear method for examining patterns of recurrence. RQA might provide a unique method for the EDX evaluation of @entity2 . RQA was used to analyze F-wave recordings from the abductor hallucis muscle in 61 @entity0 with @entity2 . Twenty-nine of these @entity0 had @entity1 as the sole cause of their @entity2 . In the other 32 @entity0 , the etiologies of the @entity2 were diverse. Commonly used EDX variables were also recorded. RQA data could separate the 29 @entity0 with @entity4 from the other 32 @entity0 (P < 0.009). Statistically significant differences in two EDX variables were also present: compound muscle action potential amplitudes (P < 0.007) and F-wave persistence (P < 0.001). RQA analysis of F-waves seemed able to distinguish @entity4 from the other @entity2 studied, and this separation was associated with specific physiological abnormalities. This study would therefore support the idea that RQA of F-waves can distinguish between types of @entity3 based on EDX data alone without prior assumptions.

title: Recurrence Quantification Analysis of F-Waves and the Evaluation of XXXX .

answer: @entity2


abstract: @entity4 ( @entity6 ) is a biomarker of @entity1 . In the present study, we tested the hypothesis that dietary @entity6 may improve cardiometabolic indices. A high fat diet (HFD) + @entity6 (50 or 400   mg/kg BW/day) was fed to @entity0 and compared with HFD + @entity5 (10   mg/kg BW/day) or HFD alone for 12 weeks. Weights and serum biochemicals (lipid profile, oral @entity2 tolerance test, leptin, adiponectin, and insulin) were measured, and mRNA levels of insulin signaling genes were determined. The results indicated that low and high doses of @entity4 (SA) improved metabolic indices, although only the oral @entity2 tolerance test, serum @entity3 , leptin, and adiponectin were significantly better than those in the HFD and HFD + @entity5 groups (P < 0.05). Furthermore, the results showed that only high-dose SA significantly affected the transcription of hepatic and adipose tissue insulin signaling genes. The data suggested that SA prevented HFD-induced insulin resistance in @entity0 after 12 weeks of administration through nontranscriptionally mediated biochemical changes that may have differentially sialylated glycoprotein structures at a low dose. At higher doses, SA induced transcriptional regulation of insulin signaling genes. These effects suggest that low and high doses of SA may produce similar metabolic outcomes in relation to insulin sensitivity through multiple mechanisms. These findings are worth studying further.

title: XXXX Supplementation Prevents High Fat Diet-Induced Insulin Resistance in @entity0 through Transcriptional and Nontranscriptional Mechanisms.

answer: @entity4


abstract: @entity4 ( @entity6 ) is a biomarker of @entity1 . In the present study, we tested the hypothesis that dietary @entity6 may improve cardiometabolic indices. A high fat diet (HFD) + @entity6 (50 or 400   mg/kg BW/day) was fed to @entity0 and compared with HFD + @entity5 (10   mg/kg BW/day) or HFD alone for 12 weeks. Weights and serum biochemicals (lipid profile, oral @entity2 tolerance test, leptin, adiponectin, and insulin) were measured, and mRNA levels of insulin signaling genes were determined. The results indicated that low and high doses of @entity4 (SA) improved metabolic indices, although only the oral @entity2 tolerance test, serum @entity3 , leptin, and adiponectin were significantly better than those in the HFD and HFD + @entity5 groups (P < 0.05). Furthermore, the results showed that only high-dose SA significantly affected the transcription of hepatic and adipose tissue insulin signaling genes. The data suggested that SA prevented HFD-induced insulin resistance in @entity0 after 12 weeks of administration through nontranscriptionally mediated biochemical changes that may have differentially sialylated glycoprotein structures at a low dose. At higher doses, SA induced transcriptional regulation of insulin signaling genes. These effects suggest that low and high doses of SA may produce similar metabolic outcomes in relation to insulin sensitivity through multiple mechanisms. These findings are worth studying further.

title: @entity4 Supplementation Prevents High Fat Diet-Induced Insulin Resistance in XXXX through Transcriptional and Nontranscriptional Mechanisms.

answer: @entity0


abstract: The prognosis of @entity0 is the result of many factors, among which the mass of the @entity2 at the time of diagnosis remains the most significant: small @entity2 have a better prognosis than larger ones and are less often accompanied by positive lymph nodes. It is therefore justifiable to search for them systematically by breast examination of all @entity1 over 30. Large-scale mass screening campains in the USA, with clinical and mammographic examination of tens of thousands of @entity1 , have proven that it is possible to detect more "early" @entity2 and reduce general mortality in the groups studied. The number of @entity2 thus detected is nevertheless so small that it does not justify the investment of so much labour and money in this kind of campaign. Systematic breast examination at regular intervals (6 months to 1 year) with regular mammographies should be confined to @entity1 in the high risk groups: @entity1 who have already undergone surgery for @entity2 of one breast, and @entity1 with a marked family history of @entity0 . For the rest of the female population, the solution seems obvious: every physician should get into the habit of performing regular clinical examination of the breasts. Most gynecologists are already doing so, but they only examine a small part of the population. The most important role in the detection of @entity0 falls to the internists and the general practitioners: they should assume responsibility for all their @entity1 ' breasts, in the same manner as they do for heart and lung examinations. They will then request additional examinations (mammography, thermography) as soon as clinical examination reveals a pathological finding. The results of GILBERTSEN [5] confirm that clinical examination remains the most valuable and least expensive method for @entity0 detection.

title: [Usefulness of detection of XXXX : the part played by the internist].

answer: @entity0


abstract: UNASSIGNED: The prevalence of @entity2 ( @entity2 ) is estimated to be 3-7.5% in @entity0 and 2-3% in @entity0 . In mentally ill population it is even higher, as these @entity0 are a high risk @entity2 group. The aim of the paper was a review of literature about the prevalence of @entity1 in @entity0 with @entity5 , @entity6 and recurrent @entity8 .The available data show that @entity2 is present in 15-48% of @entity0 with @entity5 , 21-43% of @entity0 with @entity6 and 11-18% of @entity0 with recurrent @entity8 . The lack of diagnosis of @entity2 in @entity0 with mental illnesses has multiple negative consequences. The symptoms of @entity1 might imitate the symptoms of mental illnesses such as negative symptoms of @entity5 and symptoms of @entity8 , they might as well aggravate the @entity3 . A number of the drugs used in @entity4 may aggravate the symptoms of @entity2 . @entity2 is as well the risk factor for cardiovascular and @entity7 which are a serious clinical problem in mentally ill @entity0 and contribute to shortening of their expected lifespan. From the point of view of the physicians treating @entity2 it is important to pay attention to the fact that co-existing @entity8 is the most common reason for resistant @entity1 in @entity2 @entity0 treated effectively with Continuous Positive Airway Pressure (CPAP). CPAP therapy leads to significant improvement of mood. However, in @entity5 and @entity6 @entity0 it may rarely lead to acute worsening of mental state, exacerbation of @entity9 symptoms or phase shift from @entity8 to @entity6 .

title: Obstructive sleep apnea in severe XXXX .

answer: @entity4


abstract: The introduction of the ventricular inhibited pulse generator with the feature of rate hysteresis has been associated with a variety of rhythm disturbances, some causing serious concern. This pulse generator has two different pacing rates: (1) the automatic rate, which is the interval between two successive paced beats (usually 860 msec or 70/min), and (2) the hysteresis interval, which results in a 1,000 msec delay between a sensed cardiac contraction and the next pacemaker discharge. The hysteresis interval after a sensed signal may result in long pauses that may predispose to the development of serious @entity3 . Two examples of this type of complication were recently observed. One @entity0 had bigeminal rhythm with mechanically ineffective cardiac contractions and an effective cardiac rate of 35/min; he experienced @entity5 and @entity1 during these prolonged episodes. Another @entity0 had repeated episodes of @entity6 . The @entity3 were not controlled by antiarrhythmic agents, and both @entity0 required replacement of the pulse generator. The proposed advantages of pulse generator hysteresis are (1) prolongation of battery life, and (2) maintenance of effective atrial transport; these advantages may be outweighed by undesirable @entity3 that may be associated with this mode of pacemaker function. Rate hysteresis cardiac pacemakers should be reserved for @entity0 having predominantly sinus rhythm without ventricular irritability. In @entity0 with frequent ectopic ventricular activity, @entity4 or high degree @entity2 , the rate hysteresis pacemaker offers no advantage over the conventional demand pacemaker. For @entity0 with frequent ectopic ventricular activity not easily controlled by antiarrhythmic agents, consideration should be given to the use of a permanent demand pacemaker with external rate control, which may provide greater flexibility in @entity3 management.

title: Undesirable XXXX associated with rate hysteresis pacemakers.

answer: @entity3


abstract: AIMS: The study aimed to examine five-year clinical outcomes of complete (CR), partially complete (PCR), and incomplete revascularisation (ICR) in @entity0 with unprotected left main @entity3 treated with @entity5 ( @entity5 ). @entity6 , defined as revascularisation of all vessels >= 1.5 or 2.5 mm in diameter, has been shown to correlate with outcomes after percutaneous coronary intervention (PCI). There are no data to compare revascularisation strategies on long-term clinical outcomes in @entity0 undergoing PCI of @entity3 . METHODS AND RESULTS: This prospective registry enrolled 910 consecutive @entity0 with @entity3 undergoing PCI with @entity5 implantation. CR included @entity0 who had a successful revascularisation of all diseased segments with diameter >= 1.5 mm. PCR included @entity0 who had successful revascularisation of all diseased segments with diameter >= 2.5 mm. ICR included @entity0 who did not achieve revascularisation for all diseased segments of diameter >= 2.5 mm. The primary endpoint was the incidence of major adverse @entity2 (MACE: a composite of @entity1 , @entity4 and repeat revascularisation) at five-year follow-up. CR was achieved in 386 (42.4%), PCR in 227 (25.0%), and ICR in 297 (32.6%) @entity0 . @entity0 with ICR had a significantly higher rate of MACE (29.6% vs. 22.5% and 15.5%, p<0.001) and all-cause mortality (12.5% vs. 7.0% and 6.2%; p=0.006) than those with CR and PCR at five-year follow-up. After propensity score matching, @entity0 with CR vs. PCR had similar incidences of MACE (hazard ratio [HR]: 1.16, 95% confidence interval [CI]: 0.78-1.74, p=0.46), mortality (HR: 1.27, 95% CI: 0.61-2.63, p=0.53), and @entity1 (1.8% vs. 4.5%; HR: 2.56, 95% CI: 0.80-8.17, p=0.11). On multivariable logistic regression analysis, ICR appears to be an outcome of poor clinical characteristics, comorbidities and complex coronary anatomy. CONCLUSIONS: In the treatment of @entity0 with @entity3 , ICR was associated with worse long-term clinical outcomes than CR and PCR. PCR has clinical outcomes similar to CR in @entity0 with @entity3 treated with @entity5 .

title: Clinical outcomes of "complete, partially complete, and incomplete" revascularisation at five-year follow-up after percutaneous intervention of unprotected left main @entity3 with XXXX .

answer: @entity5


abstract: AIMS: The study aimed to examine five-year clinical outcomes of complete (CR), partially complete (PCR), and incomplete revascularisation (ICR) in @entity0 with unprotected left main @entity3 treated with @entity5 ( @entity5 ). @entity6 , defined as revascularisation of all vessels >= 1.5 or 2.5 mm in diameter, has been shown to correlate with outcomes after percutaneous coronary intervention (PCI). There are no data to compare revascularisation strategies on long-term clinical outcomes in @entity0 undergoing PCI of @entity3 . METHODS AND RESULTS: This prospective registry enrolled 910 consecutive @entity0 with @entity3 undergoing PCI with @entity5 implantation. CR included @entity0 who had a successful revascularisation of all diseased segments with diameter >= 1.5 mm. PCR included @entity0 who had successful revascularisation of all diseased segments with diameter >= 2.5 mm. ICR included @entity0 who did not achieve revascularisation for all diseased segments of diameter >= 2.5 mm. The primary endpoint was the incidence of major adverse @entity2 (MACE: a composite of @entity1 , @entity4 and repeat revascularisation) at five-year follow-up. CR was achieved in 386 (42.4%), PCR in 227 (25.0%), and ICR in 297 (32.6%) @entity0 . @entity0 with ICR had a significantly higher rate of MACE (29.6% vs. 22.5% and 15.5%, p<0.001) and all-cause mortality (12.5% vs. 7.0% and 6.2%; p=0.006) than those with CR and PCR at five-year follow-up. After propensity score matching, @entity0 with CR vs. PCR had similar incidences of MACE (hazard ratio [HR]: 1.16, 95% confidence interval [CI]: 0.78-1.74, p=0.46), mortality (HR: 1.27, 95% CI: 0.61-2.63, p=0.53), and @entity1 (1.8% vs. 4.5%; HR: 2.56, 95% CI: 0.80-8.17, p=0.11). On multivariable logistic regression analysis, ICR appears to be an outcome of poor clinical characteristics, comorbidities and complex coronary anatomy. CONCLUSIONS: In the treatment of @entity0 with @entity3 , ICR was associated with worse long-term clinical outcomes than CR and PCR. PCR has clinical outcomes similar to CR in @entity0 with @entity3 treated with @entity5 .

title: Clinical outcomes of "complete, partially complete, and incomplete" revascularisation at five-year follow-up after percutaneous intervention of unprotected left main XXXX with @entity5 .

answer: @entity3


abstract: Brucellosis is a systemic @entity1 that leads to various clinical pictures and is still a significant health problem in @entity3 . In this study, 52 pediatric @entity0 diagnosed with @entity11 between January 2008 and December 2013 were examined. Clinical and laboratory findings, response to treatment, prognosis and complications were evaluated. Diagnosis of @entity11 was made based on a clinical picture compatible with the disease, together with standard tube agglutination test (SAT) positivity (1/160 or higer titer) or isolation of Brucella spp. in a sterile body fluid culture. The cases comprised 10 females and 42 males. In 75% of cases, there was a history of consumption of unpasteurized milk or dairy products. The most commonly seen symptoms and findings were @entity2 (75%), @entity12 (54%), fatigue (19%), @entity4 (44%), @entity5 (42%) and @entity8 (19%). Atypical presentations were seen in one case of epidydymo- @entity13 and three cases of bleeding of the nose and gums. In the laboratory examinations, @entity6 was determined in 56% of cases, @entity10 in 40% and @entity9 in 27%. In blood cultures taken from 41 @entity0 , Brucella spp. were isolated in 23 (56.1%). All @entity0 recovered, and sequelae were seen only in a @entity0 with @entity7 . In conclusion, although @entity11 leads to many different clinical pictures, a very good response to treatment can be obtained. If effective treatment cannot be implemented in time, the disease may become chronic, and complications and relapses may be encountered. Therefore, early diagnosis and treatment is of great importance.

title: Evaluation of childhood XXXX in the central Black Sea region.

answer: @entity11


abstract: BACKGROUND: Hemorheological and glycemic parameters and high density lipoprotein (HDL) @entity2 are used as biomarkers of @entity8 and @entity7 . OBJECTIVE: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), @entity10 , fasting @entity5 , glycated hemoglobin (HbA1c), and HDL @entity2 in the prediction of major adverse cardiovascular events (MACE) and @entity4 ( @entity4 ) in an outpatient population. METHODS: 708 stable @entity0 who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. @entity0 were divided into two groups, @entity0 without MACE and @entity0 with MACE, which included @entity3 , acute @entity6 , newly diagnosed @entity4 , and @entity1 . We compared hemorheological and glycemic parameters and lipid profiles between the groups. RESULTS: @entity0 with MACE had significantly higher ESR, @entity10 , fasting @entity5 , and HbA1c, while lower HDL @entity2 compared with @entity0 without MACE. High ESR and @entity10 and low HDL @entity2 significantly increased the risk of MACE in multivariate regression analysis. In @entity0 with MACE, high @entity10 and HbA1c levels increased the risk of multivessel @entity4 . Furthermore, ESR and @entity10 were significantly positively correlated with HbA1c and negatively correlated with HDL @entity2 , however not correlated with fasting @entity5 . CONCLUSION: @entity9 , poor glycemic control, and low HDL @entity2 are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and @entity4 in outpatients.

title: Hemorheological and Glycemic Parameters and HDL XXXX for the Prediction of Cardiovascular Events.

answer: @entity2


abstract: UNASSIGNED: Intranidal vessel geometry and organization underlying flow within @entity2 ( @entity1 ) is poorly understood. We examine the relationship between intranidal vessel characteristics and @entity1 flow. Records of @entity0 with @entity1 evaluated at our institution between 2007 and 2013 were retrospectively reviewed. @entity0 were included if surgical specimens were available and flows were obtained before treatment using quantitative magnetic resonance angiography. Intranidal vessels were identified and the diameter and cross-sectional area of each vessel were measured from digitized images of specimen slides. The relationship between vessel diameter, vessel cross-sectional area, @entity1 volume, and @entity1 flow was assessed. Twenty-nine @entity0 were included. Mean total number of vessels per specimen was 133. Mean total @entity1 flow was 340  276mL/min. Mean vessel diameter ranged from 0.18-2.37mm and mean vessel cross-sectional area ranged from 0.09-9.46mm(2). Linear regression analysis showed that total flow is significantly associated with larger @entity1 volume (R(2)=0.28, P=0.007), but not with number of vessels per section of the specimen (P=0.20) or mean vessel diameter (P=0.92). Exponential regression analysis demonstrated that @entity1 flow is significantly correlated to the sum of the cross-sectional vessel areas within each specimen (R(2)=0.16, P=0.05). Total @entity1 flow is significantly related to sum of the cross-sectional areas of all vessels within each nidus, rather than to total number of vessels or mean nidal vessel diameter. This finding suggests that the sum of the cross-sectional areas of intranidal vessels likely determines the resistance to flow within a @entity2 .

title: Effects of nidus microarchitecture on XXXX hemodynamics.

answer: @entity2


abstract: BACKGROUND: Parasitic infections pose a significant health risk in developing nations and are a major cause of morbidity and mortality worldwide. In the Republic of Tanzania, the CDC estimates that 51.5% of the population is infected with one or more @entity4 . If diagnosed early, the consequences of chronic @entity2 can potentially be avoided. METHODS: Six first-year medical students were recruited to enroll @entity0 in the study. They underwent ten hours of formal, hands-on, ultrasound which included basic cardiac, hepatobiliary, renal, pulmonary and FAST scan ultrasound. A World Health Organization protocol with published grading scales was adapted and used to assess for pathology in each @entity0 's liver, bladder, kidneys, and spleen. RESULTS: A total of 59 @entity0 were enrolled in the study. Students reported a sensitivity of 96% and specificity of 100% for the presence of a dome shaped bladder, a sensitivity and specificity of 100% for bladder thickening, a sensitivity and specificity of 100% for portal @entity1 and @entity3 . The sensitivity was 81% with a specificity of 100% for presence of portal vein distention. The sensitivity was 100% with a specificity of 90% for dilated bowel. CONCLUSIONS: Ultrasound has shown a promise at helping to identify pathology in rural communities with limited resources such as Tanzania. Our data suggest that minimally trained first year medical students are able to perform basic ultrasound scans that can identify ultrasonographic markers of @entity2 .

title: A feasibility study to determine if minimally trained medical students can identify markers of chronic XXXX using bedside ultrasound in rural Tanzania.

answer: @entity2


abstract: Renal biopsies of 23 @entity11 addicts who presented with the @entity7 were examined by light and electron microscopy. The majority of @entity0 (14) showed @entity2 on light microscopy, four @entity0 showed "minimal change", and two were classified as "focal @entity6 ." In one case focal mesangial proliferation was the outstanding feature; one @entity0 had @entity1 ; and one had @entity10 and dysproteinemia. Visceral epithelial swelling and proliferation were present in 14 @entity0 on light on light microscopy. Electron microscopy showed distinct podocyte changes consisting of loss of foot processes, vacuolization, and cytoplasmic degeneration; focal separation of podocytes from basement membranes was found in 11 of 18 cases. In some instances a few electron-dense deposits were present in the mesangium. @entity2 was not encountered, although it occurs in 30 to 40% of unselected adult @entity7 individuals. Of 15 @entity0 followed for 2 months to 5 years, one died of @entity11 @entity5 , eight went into @entity3 , two improved, and four continued to have @entity4 . It is concluded that @entity7 of @entity11 addicts is most often associated with @entity2 and occasionally with @entity8 or focal @entity6 . Conceivably these three conditions represent different phases of one disease process, although different reactions to @entity11 or its various vehicles and contaminants cannot be excluded. The morphologic resemblance to experimental @entity12 and @entity13 -induced @entity9 suggests a possible toxic origin.

title: Glomerular morphology in @entity7 XXXX addicts.

answer: @entity11


abstract: Renal biopsies of 23 @entity11 addicts who presented with the @entity7 were examined by light and electron microscopy. The majority of @entity0 (14) showed @entity2 on light microscopy, four @entity0 showed "minimal change", and two were classified as "focal @entity6 ." In one case focal mesangial proliferation was the outstanding feature; one @entity0 had @entity1 ; and one had @entity10 and dysproteinemia. Visceral epithelial swelling and proliferation were present in 14 @entity0 on light on light microscopy. Electron microscopy showed distinct podocyte changes consisting of loss of foot processes, vacuolization, and cytoplasmic degeneration; focal separation of podocytes from basement membranes was found in 11 of 18 cases. In some instances a few electron-dense deposits were present in the mesangium. @entity2 was not encountered, although it occurs in 30 to 40% of unselected adult @entity7 individuals. Of 15 @entity0 followed for 2 months to 5 years, one died of @entity11 @entity5 , eight went into @entity3 , two improved, and four continued to have @entity4 . It is concluded that @entity7 of @entity11 addicts is most often associated with @entity2 and occasionally with @entity8 or focal @entity6 . Conceivably these three conditions represent different phases of one disease process, although different reactions to @entity11 or its various vehicles and contaminants cannot be excluded. The morphologic resemblance to experimental @entity12 and @entity13 -induced @entity9 suggests a possible toxic origin.

title: Glomerular morphology in XXXX @entity11 addicts.

answer: @entity7


abstract: PURPOSE: Disturbed peripapillary microcirculation may have a role in the development of @entity3 . Recently, using noninvasive optical coherence tomography (OCT) angiography with the AngioVue OCT (Optovue Inc., -Fremont, CA, USA), reduced peripapillary vessel density was found in @entity3 . In this case series, we investigate the relationship between retinal nerve fiber layer (RNFL) damage and @entity6 ( @entity6 , % of the analyzed retinal area) in the superotemporal (ST), inferotemporal (IT), and temporal (T) peripapillary sectors in normal, ocular @entity0 (OHT), and primary @entity5 eyes. CASE REPORT: The AngioVue OCT and the 2015.100.0.33 software version was used for @entity6 measurements. The @entity6 in the radial peripapillary capillary layer was similar (approximately 60%) in all 3 sectors in healthy eyes. In @entity3 with severe ST and/or IT RNFL defect, @entity6 declined to 32%-45% in the damaged sectors but remained above 55% in the T sector. In the OHT eyes with no @entity1 and no RNFL sector outside the normal limits but with mild ST or IT RNFL damage, @entity6 declined to 54% in the involved sector in all cases, while it remained around 60% in the other sectors. CONCLUSIONS: Our cases suggest that PADF measurements can identify decreased peripapillary perfusion early in the @entity4 thinning process, prior to the development of clinically significant RNFL @entity1 . Decreased @entity6 corresponds spatially with the damaged RNFL bundles. The results suggest that prospective studies using @entity6 may help to understand the role of @entity2 in @entity3 .

title: Vessel density calculated from OCT angiography in 3 peripapillary sectors in normal, ocular @entity0 , and XXXX eyes.

answer: @entity3


abstract: PURPOSE: Disturbed peripapillary microcirculation may have a role in the development of @entity3 . Recently, using noninvasive optical coherence tomography (OCT) angiography with the AngioVue OCT (Optovue Inc., -Fremont, CA, USA), reduced peripapillary vessel density was found in @entity3 . In this case series, we investigate the relationship between retinal nerve fiber layer (RNFL) damage and @entity6 ( @entity6 , % of the analyzed retinal area) in the superotemporal (ST), inferotemporal (IT), and temporal (T) peripapillary sectors in normal, ocular @entity0 (OHT), and primary @entity5 eyes. CASE REPORT: The AngioVue OCT and the 2015.100.0.33 software version was used for @entity6 measurements. The @entity6 in the radial peripapillary capillary layer was similar (approximately 60%) in all 3 sectors in healthy eyes. In @entity3 with severe ST and/or IT RNFL defect, @entity6 declined to 32%-45% in the damaged sectors but remained above 55% in the T sector. In the OHT eyes with no @entity1 and no RNFL sector outside the normal limits but with mild ST or IT RNFL damage, @entity6 declined to 54% in the involved sector in all cases, while it remained around 60% in the other sectors. CONCLUSIONS: Our cases suggest that PADF measurements can identify decreased peripapillary perfusion early in the @entity4 thinning process, prior to the development of clinically significant RNFL @entity1 . Decreased @entity6 corresponds spatially with the damaged RNFL bundles. The results suggest that prospective studies using @entity6 may help to understand the role of @entity2 in @entity3 .

title: Vessel density calculated from OCT angiography in 3 peripapillary sectors in normal, ocular XXXX , and @entity3 eyes.

answer: @entity0


abstract: PURPOSE: To describe the ultrasound biomicroscopic (UBM) features and complications associated with @entity2 . DESIGN: A retrospective case series. METHODS: Thirteen @entity0 with @entity2 were identified in a 10 year period study at a ophthalmologic reference Center in Mexico City. The variables included demographic data, ocular and medical history, clinical course, and complications. All @entity0 were examined by UBM, and type, number, location, and acoustic characteristics of cysts were evaluated. Descriptive statistics were performed. RESULTS: Thirteen @entity0 were included (8 @entity0 and 5 @entity0 ). The mean age was 44.5  15.5 years (range 6-70 years). The origin most prevalent was neuroepithelial (92.3%), and 7.7% had stromal cysts. Regarding to location 76.9% were found in the periphery, and 69.2% between meridians II and VI. All cysts showed a moderate to high reflectivity in the wall. Complications were present in 38.5% of cases (15.4% partial angle closure, 15.4% secondary angle closure @entity1 and 7.7% dyscoria). CONCLUSIONS: Most cysts are derived from iris pigmented epithelium, with a benign course and a minor rate of complications. The UBM is an indispensable tool that allows us to plan more specific and conservative treatments, with less damage to ocular structures and, therefore, better visual prognosis.

title: Ultrasound biomicroscopic analysis of XXXX .

answer: @entity2


abstract: PURPOSE: To study the characteristics of @entity2 secondary to @entity4 (ERM) using improved-resolution spectral-domain optical coherence tomography ( @entity3 OCT) and their evolution after surgery. DESIGN: Retrospective, observational cohort study. @entity0 : The files of 344 @entity0 operated on consecutively for ERM over a 2-year period in a single tertiary ophthalmologic center were reviewed. @entity0 with @entity1 , secondary ERM, or both were excluded. METHODS: In all, 293 eyes with idiopathic ERM were included in the final analysis. Fundus photographs were reviewed to assess the presence of a yellow foveal spot, and @entity3 OCT analysis was performed. MAIN OUTCOME MEASURES: Presence or absence of a @entity2 and its @entity3 OCT characteristics before and after surgery at 1 month, 3 months, and at final visit; best-corrected visual acuity (BCVA) and central macular thickness at baseline, 1 month, 3 months, and at the final visit. RESULTS: Before surgery, a @entity3 ( @entity3 ) corresponding to the yellow deposit was present in 59 of 293 eyes (20%). No difference was found for the postoperative BCVA between the 59 eyes with @entity3 before surgery and the 234 eyes without @entity3 (0.253    0.14 logarithm of the minimum angle of resolution [logMAR] vs. 0.262    0.24 logMAR, respectively; P  = 0.6). Sixty-eight percent (n  = 40/59) of @entity3 disappeared after surgery during a mean follow-up of 4.8    3.2 months, most of them (62%) before month 3. Among eyes with preoperative @entity3 , no difference was found for the postoperative BCVA between eyes with disappeared @entity3 and those with persistent @entity3 . CONCLUSIONS: @entity3 secondary to idiopathic ERM were observed in 20% of these eyes. They disappeared after surgery in more than two thirds of cases, usually early during postoperative course. @entity3 do not affect visual outcome and should not interfere with surgical decision making.

title: Evolution of Subfoveal Detachments Secondary to Idiopathic XXXX after Surgery.

answer: @entity4


abstract: INTRODUCTION: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which @entity2 ( oct) can be quantified. We hypothesize that qualitative (image assessment) and quantitative ( @entity2 ,  oct) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from (pre) malignant penile tissue. MATERIALS AND METHODS: Optical coherence tomography-imaging was performed prior to punch biopsy in 18 consecutive @entity0 with a suspicious lesion at the outpatient clinic of the NKI-AVL. Qualitative analysis consisted of visual assessment of clear layers and a visible lower border of the lesions, quantitative analysis comprised of determination of the epidermal layer @entity1 and  oct. Results were grouped according to histopathology reports. RESULTS: Qualitative analysis showed a statistically significant difference (P = 0.047) between benign and (pre) malignant lesions. Quantitative analysis showed that @entity2 was significantly different between benign and (pre) malignant tissue, respectively, P = 0.001 and P < 0.001. CONCLUSION: In this preliminary study, qualitative and quantitative analysis of OCT-images of suspicious @entity3 shows differences between benign lesions and (pre) malignant lesions. These results encourage further research in a larger study population.

title: Optical coherence tomography accurately identifies XXXX with penile (pre) malignant lesions: A single center prospective study.

answer: @entity0


abstract: BACKGROUND: Freezing of gait ( @entity5 ) is a common and debilitating condition in @entity1 ( @entity1 ) associated with @entity2 . A subtype of @entity5 does not respond to dopaminergic therapy and may be related to @entity3 . This pilot study explores the effects of @entity4 on gait in @entity1 @entity0 with dopa-unresponsive @entity5 using a novel paradigm for objective gait assessment. FINDINGS: Ten @entity0 with @entity1 and dopa-unresponsive @entity5 were enrolled in this eight-week open label pilot study. Assessments included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning, while performing a dual task. Clinical, and subjective assessments of gait, quality of life, and safety were also administered. The primary outcome was a validated subjective assessment for @entity5 ( @entity5 ). @entity4 was well tolerated, however, no significant change was observed in the primary outcome. The gait analysis protocol correlated well with clinical scales, but not with subjective assessments. @entity6 @entity0 were more likely to increase gait velocity (p   =   0.033), and improved in other clinical assessments. CONCLUSIONS: Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this @entity0 population, and may be superior correlates of @entity5 severity than subjective measures. These findings can inform future trials in this population.

title: Pilot study of XXXX in @entity0 with @entity1 and dopa-unresponsive Freezing of Gait.

answer: @entity4


abstract: BACKGROUND: Freezing of gait ( @entity5 ) is a common and debilitating condition in @entity1 ( @entity1 ) associated with @entity2 . A subtype of @entity5 does not respond to dopaminergic therapy and may be related to @entity3 . This pilot study explores the effects of @entity4 on gait in @entity1 @entity0 with dopa-unresponsive @entity5 using a novel paradigm for objective gait assessment. FINDINGS: Ten @entity0 with @entity1 and dopa-unresponsive @entity5 were enrolled in this eight-week open label pilot study. Assessments included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning, while performing a dual task. Clinical, and subjective assessments of gait, quality of life, and safety were also administered. The primary outcome was a validated subjective assessment for @entity5 ( @entity5 ). @entity4 was well tolerated, however, no significant change was observed in the primary outcome. The gait analysis protocol correlated well with clinical scales, but not with subjective assessments. @entity6 @entity0 were more likely to increase gait velocity (p   =   0.033), and improved in other clinical assessments. CONCLUSIONS: Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this @entity0 population, and may be superior correlates of @entity5 severity than subjective measures. These findings can inform future trials in this population.

title: Pilot study of @entity4 in @entity0 with XXXX and dopa-unresponsive Freezing of Gait.

answer: @entity1


abstract: BACKGROUND: Freezing of gait ( @entity5 ) is a common and debilitating condition in @entity1 ( @entity1 ) associated with @entity2 . A subtype of @entity5 does not respond to dopaminergic therapy and may be related to @entity3 . This pilot study explores the effects of @entity4 on gait in @entity1 @entity0 with dopa-unresponsive @entity5 using a novel paradigm for objective gait assessment. FINDINGS: Ten @entity0 with @entity1 and dopa-unresponsive @entity5 were enrolled in this eight-week open label pilot study. Assessments included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning, while performing a dual task. Clinical, and subjective assessments of gait, quality of life, and safety were also administered. The primary outcome was a validated subjective assessment for @entity5 ( @entity5 ). @entity4 was well tolerated, however, no significant change was observed in the primary outcome. The gait analysis protocol correlated well with clinical scales, but not with subjective assessments. @entity6 @entity0 were more likely to increase gait velocity (p   =   0.033), and improved in other clinical assessments. CONCLUSIONS: Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this @entity0 population, and may be superior correlates of @entity5 severity than subjective measures. These findings can inform future trials in this population.

title: Pilot study of @entity4 in XXXX with @entity1 and dopa-unresponsive Freezing of Gait.

answer: @entity0


abstract: OBJECTIVE: Various clinical risk factors, including high breast density, have been shown to be associated with @entity0 . The utility of using relative and absolute area-based breast density-related measures was evaluated as an alternative to clinical risk factors in @entity1 risk assessment at the time of screening mammography. METHODS: Contralateral mediolateral oblique digital mammography images from 392 females with @entity0 and 817 age-matched controls were analysed. Information on clinical risk factors was obtained from the provincial breast-imaging information system. Breast density-related measures were assessed using a fully automated breast density measurement software. Multivariable logistic regression was conducted, and area under the receiver-operating characteristic (AUROC) curve was used to evaluate the performance of three @entity1 risk models: the first using only clinical risk factors, the second using only density-related measures and the third using both clinical risk factors and density-related measures. RESULTS: The risk factor-based model generated an AUROC of 0.535, while the model including only breast density-related measures generated a significantly higher AUROC of 0.622 (p   <   0.001). The third combined model generated an AUROC of 0.632 and performed significantly better than the risk factor model (p   <   0.001) but not the density-related measures model (p   =   0.097). CONCLUSION: Density-related measures from screening mammograms at the time of screen may be superior predictors of @entity1 compared with clinical risk factors. Advances in knowledge: @entity0 risk models based on density-related measures alone can outperform risk models based on clinical factors. Such models may support the development of personalized breast-screening protocols.

title: Utility of relative and absolute measures of mammographic density vs clinical risk factors in evaluating XXXX risk at time of screening mammography.

answer: @entity0