abstract: @entity0 ( @entity1 ) hydrogels have been investigated for a number of applications in tissue engineering. The hydrogels can be designed to mimic tissues that have desired chemical and mechanical properties, but their physical structure can hinder cell migration, tissue invasion, and molecular transport. Synthesis of porous @entity1 hydrogels could improve transport, enhance cell behavior, and increase the surface area available for cell adhesion. Salt leaching methods have been used extensively to generate porous biomaterial scaffolds but have not previously been applied to hydrogels. In this article we describe a modification of traditional salt leaching techniques for application to hydrogels. Salt-saturated polymer precursor solutions are prepared, and salt crystals of a defined size are added before polymerization. The salt crystals are then leached out, resulting in porous hydrogels. Examples are provided for application of this technique to @entity1 hydrogels. Porous @entity1 hydrogels were generated with pore sizes ranging from 15 to 86   microm and porosities from 30% to 75%. Porous hydrogels that were incorporated with a cell adhesion peptide supported cell adhesion with morphology varying with pore size. The simple, reproducible technique described here could be used to generate porous hydrogels with controlled pore sizes for applications in tissue engineering.

title: Generation of porous XXXX hydrogels by salt leaching.

answer: @entity0


abstract: BACKGROUND: The treatment of molar @entity7 remains a considerable challenge in clinical practice. The degree of success in the management of furcation involvement is highly variable and inversely related to initial @entity1 ( @entity1 ) measurements in these lesions. The identification of clinical measurements influential to the treatment outcomes is critical to optimize the results of surgical periodontal therapy. Therefore, the objective of this study was to evaluate the clinical response of mandibular buccal Class II furcation lesions to a combined regenerative treatment modality. METHODS: Sixty @entity0 were divided into two (n = 30) treatment groups. An experimental combined regenerative therapy (ET) was compared to open flap debridement (OFD). The ET was a combination of a composite graft consisting of bioabsorbable @entity3 and @entity4 (3:1), a guided tissue regeneration barrier, and a coronally advanced flap. The clinical variables evaluated were plaque, @entity2 on probing, @entity6 , @entity1 , vertical attachment level (VAL), horizontal attachment level (HAL), furcation vertical height, furcation horizontal depth, and the amount of tissue under the barrier membrane at uncovering. Reevaluation was performed 12 months after the surgical procedure. RESULTS: Both treatments resulted in improvements in all clinical variables evaluated. Postoperative measurements revealed a reduction in @entity1 of 3.65 +/- 0.6 mm and 0.60 +/- 1.0 mm; VAL gains of 3.05 +/- 0.6 mm and 0.65 +/- 0.6 mm and HAL gains of 3.45 +/- 1.3 mm and 0.55 +/- 0.7 mm in the ET and OFD groups, respectively. In the ET group, significant positive correlations were found between baseline @entity1 and @entity1 reduction at 12 months, and the initial VAL correlated positively with @entity5 . The horizontal furcation depth and amount of tissue formed under the membrane at uncovering correlated positively with @entity8 . For the OFD group, the initial @entity1 correlated positively with @entity8 and correlated negatively with recession. Initial VAL correlated positively with @entity8 . The initial HAL correlated negatively with recession at 12 months. CONCLUSIONS: ET exhibited significantly better clinical results, with more @entity8 , and a higher frequency of furcation closure compared to OFD and showed promise as a regenerative treatment technique. The ability to predict a response to treatment based upon pretreatment parameters was not consistent between groups; thus, prediction of treatment outcomes based on pretreatment measurements should be carefully evaluated for each treatment modality.

title: Efficacy of combined regenerative treatments in @entity0 mandibular class II XXXX .

answer: @entity7


abstract: BACKGROUND: The treatment of molar @entity7 remains a considerable challenge in clinical practice. The degree of success in the management of furcation involvement is highly variable and inversely related to initial @entity1 ( @entity1 ) measurements in these lesions. The identification of clinical measurements influential to the treatment outcomes is critical to optimize the results of surgical periodontal therapy. Therefore, the objective of this study was to evaluate the clinical response of mandibular buccal Class II furcation lesions to a combined regenerative treatment modality. METHODS: Sixty @entity0 were divided into two (n = 30) treatment groups. An experimental combined regenerative therapy (ET) was compared to open flap debridement (OFD). The ET was a combination of a composite graft consisting of bioabsorbable @entity3 and @entity4 (3:1), a guided tissue regeneration barrier, and a coronally advanced flap. The clinical variables evaluated were plaque, @entity2 on probing, @entity6 , @entity1 , vertical attachment level (VAL), horizontal attachment level (HAL), furcation vertical height, furcation horizontal depth, and the amount of tissue under the barrier membrane at uncovering. Reevaluation was performed 12 months after the surgical procedure. RESULTS: Both treatments resulted in improvements in all clinical variables evaluated. Postoperative measurements revealed a reduction in @entity1 of 3.65 +/- 0.6 mm and 0.60 +/- 1.0 mm; VAL gains of 3.05 +/- 0.6 mm and 0.65 +/- 0.6 mm and HAL gains of 3.45 +/- 1.3 mm and 0.55 +/- 0.7 mm in the ET and OFD groups, respectively. In the ET group, significant positive correlations were found between baseline @entity1 and @entity1 reduction at 12 months, and the initial VAL correlated positively with @entity5 . The horizontal furcation depth and amount of tissue formed under the membrane at uncovering correlated positively with @entity8 . For the OFD group, the initial @entity1 correlated positively with @entity8 and correlated negatively with recession. Initial VAL correlated positively with @entity8 . The initial HAL correlated negatively with recession at 12 months. CONCLUSIONS: ET exhibited significantly better clinical results, with more @entity8 , and a higher frequency of furcation closure compared to OFD and showed promise as a regenerative treatment technique. The ability to predict a response to treatment based upon pretreatment parameters was not consistent between groups; thus, prediction of treatment outcomes based on pretreatment measurements should be carefully evaluated for each treatment modality.

title: Efficacy of combined regenerative treatments in XXXX mandibular class II @entity7 .

answer: @entity0


abstract: OBJECTIVE AND IMPORTANCE: @entity14 , @entity8 , and septic cavernous sinus @entity13 are all rare and potentially lethal conditions. The occurrence of all three in a single @entity0 has not previously been described. We present such a case occurring in a young, otherwise healthy @entity0 . CLINICAL PRESENTATION: A 26-year-old @entity0 with a remote history of @entity11 developed rapidly progressive @entity2 , @entity6 , right eye @entity5 , @entity1 , proptosis, and @entity7 . Magnetic resonance imaging demonstrated diffuse pansinusitis, including @entity17 , and extension of @entity4 and infection into the adjacent cavernous sinuses, pituitary gland, and posterior fossa. INTERVENTION: Urgent drainage of the ethmoid and maxillary sinuses was performed; pus was not identified. The @entity0 continued to deteriorate clinically with worsening of visual acuity. Computed tomography of the head performed the next day revealed worsening @entity12 and an enlarging @entity15 . Urgent ventricular drainage and evacuation of the @entity14 was performed, and subsequently, the @entity0 's clinical course improved. The microbiology results revealed alpha hemolytic streptococcus and coagulase-negative staphylococcus species. The @entity0 survived but during the follow-up period had a @entity9 and @entity16 . CONCLUSION: Paranasal @entity11 can have devastating @entity10 . Involvement of the adjacent pituitary gland and cavernous sinuses can result in serious @entity3 or mortality, and retrograde spread of infection through the basal venous system can result in subdural or parenchymal brain involvement. A high index of suspicion and aggressive medical and surgical treatment are crucial for @entity0 survival, but the morbidity rate remains high. Our @entity0 survived but lost anterior pituitary function and vision in his right eye.

title: XXXX , @entity8 , and septic cavernous sinus @entity13 secondary to paranasal @entity11 : case report.

answer: @entity15


abstract: OBJECTIVE AND IMPORTANCE: @entity14 , @entity8 , and septic cavernous sinus @entity13 are all rare and potentially lethal conditions. The occurrence of all three in a single @entity0 has not previously been described. We present such a case occurring in a young, otherwise healthy @entity0 . CLINICAL PRESENTATION: A 26-year-old @entity0 with a remote history of @entity11 developed rapidly progressive @entity2 , @entity6 , right eye @entity5 , @entity1 , proptosis, and @entity7 . Magnetic resonance imaging demonstrated diffuse pansinusitis, including @entity17 , and extension of @entity4 and infection into the adjacent cavernous sinuses, pituitary gland, and posterior fossa. INTERVENTION: Urgent drainage of the ethmoid and maxillary sinuses was performed; pus was not identified. The @entity0 continued to deteriorate clinically with worsening of visual acuity. Computed tomography of the head performed the next day revealed worsening @entity12 and an enlarging @entity15 . Urgent ventricular drainage and evacuation of the @entity14 was performed, and subsequently, the @entity0 's clinical course improved. The microbiology results revealed alpha hemolytic streptococcus and coagulase-negative staphylococcus species. The @entity0 survived but during the follow-up period had a @entity9 and @entity16 . CONCLUSION: Paranasal @entity11 can have devastating @entity10 . Involvement of the adjacent pituitary gland and cavernous sinuses can result in serious @entity3 or mortality, and retrograde spread of infection through the basal venous system can result in subdural or parenchymal brain involvement. A high index of suspicion and aggressive medical and surgical treatment are crucial for @entity0 survival, but the morbidity rate remains high. Our @entity0 survived but lost anterior pituitary function and vision in his right eye.

title: @entity15 , XXXX , and septic cavernous sinus @entity13 secondary to paranasal @entity11 : case report.

answer: @entity8


abstract: OBJECTIVE AND IMPORTANCE: @entity14 , @entity8 , and septic cavernous sinus @entity13 are all rare and potentially lethal conditions. The occurrence of all three in a single @entity0 has not previously been described. We present such a case occurring in a young, otherwise healthy @entity0 . CLINICAL PRESENTATION: A 26-year-old @entity0 with a remote history of @entity11 developed rapidly progressive @entity2 , @entity6 , right eye @entity5 , @entity1 , proptosis, and @entity7 . Magnetic resonance imaging demonstrated diffuse pansinusitis, including @entity17 , and extension of @entity4 and infection into the adjacent cavernous sinuses, pituitary gland, and posterior fossa. INTERVENTION: Urgent drainage of the ethmoid and maxillary sinuses was performed; pus was not identified. The @entity0 continued to deteriorate clinically with worsening of visual acuity. Computed tomography of the head performed the next day revealed worsening @entity12 and an enlarging @entity15 . Urgent ventricular drainage and evacuation of the @entity14 was performed, and subsequently, the @entity0 's clinical course improved. The microbiology results revealed alpha hemolytic streptococcus and coagulase-negative staphylococcus species. The @entity0 survived but during the follow-up period had a @entity9 and @entity16 . CONCLUSION: Paranasal @entity11 can have devastating @entity10 . Involvement of the adjacent pituitary gland and cavernous sinuses can result in serious @entity3 or mortality, and retrograde spread of infection through the basal venous system can result in subdural or parenchymal brain involvement. A high index of suspicion and aggressive medical and surgical treatment are crucial for @entity0 survival, but the morbidity rate remains high. Our @entity0 survived but lost anterior pituitary function and vision in his right eye.

title: @entity15 , @entity8 , and septic cavernous sinus XXXX secondary to paranasal @entity11 : case report.

answer: @entity13


abstract: OBJECTIVE AND IMPORTANCE: @entity14 , @entity8 , and septic cavernous sinus @entity13 are all rare and potentially lethal conditions. The occurrence of all three in a single @entity0 has not previously been described. We present such a case occurring in a young, otherwise healthy @entity0 . CLINICAL PRESENTATION: A 26-year-old @entity0 with a remote history of @entity11 developed rapidly progressive @entity2 , @entity6 , right eye @entity5 , @entity1 , proptosis, and @entity7 . Magnetic resonance imaging demonstrated diffuse pansinusitis, including @entity17 , and extension of @entity4 and infection into the adjacent cavernous sinuses, pituitary gland, and posterior fossa. INTERVENTION: Urgent drainage of the ethmoid and maxillary sinuses was performed; pus was not identified. The @entity0 continued to deteriorate clinically with worsening of visual acuity. Computed tomography of the head performed the next day revealed worsening @entity12 and an enlarging @entity15 . Urgent ventricular drainage and evacuation of the @entity14 was performed, and subsequently, the @entity0 's clinical course improved. The microbiology results revealed alpha hemolytic streptococcus and coagulase-negative staphylococcus species. The @entity0 survived but during the follow-up period had a @entity9 and @entity16 . CONCLUSION: Paranasal @entity11 can have devastating @entity10 . Involvement of the adjacent pituitary gland and cavernous sinuses can result in serious @entity3 or mortality, and retrograde spread of infection through the basal venous system can result in subdural or parenchymal brain involvement. A high index of suspicion and aggressive medical and surgical treatment are crucial for @entity0 survival, but the morbidity rate remains high. Our @entity0 survived but lost anterior pituitary function and vision in his right eye.

title: @entity15 , @entity8 , and septic cavernous sinus @entity13 secondary to paranasal XXXX : case report.

answer: @entity11


abstract: BACKGROUND: Infliximab, a chimeric monoclonal antibody, has been shown to be effective for moderate to severe @entity4 . Clinical experience with long-term infliximab therapy for @entity4 is accumulating, and it is therefore important to share our experience with its use in real-life clinical practice. OBJECTIVES: To report our experience with infliximab (Remicade; Schering Plough, Kenilworth, NJ, U.S.A.) for the treatment of moderate to severe @entity4 (and/or @entity2 ) from a single clinic in Greece. @entity0 AND METHODS: Between August 2004 and March 2008, 62 @entity0 presenting to our clinic with moderate to severe @entity4 were treated with infliximab. Disease phenotype, clinical course, disease severity and adverse events were assessed throughout the treatment period. RESULTS: Infliximab resulted in a reduction of median Psoriasis Area and Severity Index (PASI) of 70% at week 6 and 84.4% at week 14. Nineteen @entity0 who have completed 1 year on infliximab treatment experienced sustained efficacy with a median PASI improvement of 92.16% and a Physician's Global Assessment (PGA) of 'clear' or 'almost clear', while nine @entity0 have reached approximately 20 months of continuous therapy. All @entity0 with @entity5 showed marked improvement in their clinical symptoms following the first infusion. Eight @entity0 (12.9%) experienced adverse events that required discontinuation of treatment. There were no statistically significant differences in PASI and Dermatology Life Quality Index (DLQI) scores between @entity0 with @entity2 and those with only @entity1 , or between those who received @entity3 , either from the beginning or during infliximab therapy, and those who did not receive @entity3 at all. Selected @entity0 of interest are discussed. CONCLUSIONS: The above data confirm previous reports that treatment with infliximab is an efficacious and safe option for @entity0 with moderate to severe @entity4 (and/or @entity2 ). Long-term follow-up, continued pharmacovigilance, and controlled comparative studies will be required to fully evaluate its use in the treatment of @entity4 .

title: Infliximab for the treatment of XXXX in Greece: 4 years of clinical experience at a single centre.

answer: @entity4


abstract: OBJECTIVE: To summarize the clinical and spiral computed tomography (CT) features of undifferentiated @entity5 (UELS) in adults. METHODS: Clinical and CT findings of four adult @entity0 with pathology-approved UELS were retrospectively analyzed with a literature review. All @entity0 were examined using a plain and enhanced spiral CT scan. RESULTS: The @entity0 were two @entity0 and two @entity0 with a mean age of 36.5 years. The clinical manifestations were the right upper quadrant mass, @entity2 (n = four) and intermittent @entity4 (n = three). Laboratory tests showed a mild elevation of @entity3 in one @entity0 and mildly @entity5 in two. @entity7 was present in one @entity0 coexistent with @entity1 . CT findings indicated a huge well-defined cystic-solid mass with varying degrees of enhancement of the solid component. Irregular high-density lesions showing @entity6 occurred in three @entity0 and the inferior vena cava was compressed in one. CONCLUSION: UELS showed a solitary and predominantly cystic or multicystic appearance on CT imaging compared with ultrasound (US) from the medical literature, which shows a predominantly hypoechoic mass. The laboratory tests were normal or mildly abnormal despite the presence of the large mass. The combination of these clinical features and CT findings together with those of US are helpful in making a prospective diagnosis.

title: Clinical features and spiral computed tomography analysis of undifferentiated XXXX in adults.

answer: @entity5


abstract: A microemulsion liquid chromatographic (MELC) method was developed for the determination of @entity2 in @entity0 plasma. The assay was performed on a Hypersil BDS @entity5 column, and the effects of each component in the microemulsion mobile phase on the elution were investigated. The optimized microemulsion mobile phase consisted of 0.5% @entity1 containing 3.0% @entity3 , 0.8% @entity7 , 6.0% @entity6 . The flow rate was 1.0 mL/min, and the separation was operated at ambient temperature. The fluorescence excitation and emission wavelengths were 274 nm and 312 nm, respectively. The plasma samples were diluted with the mobile phase and centrifuged before injection. The calibration curve of @entity2 was linear within the range of 0.25 - 10 microg/mL. The method recoveries were (98.2 +/- 1.9)% - (104.6 +/- 2.2)%. The intra-day @entity4 ( @entity4 ) of peak area were 1.42% -2.43%, and the inter-day @entity4 were 2.75% - 4.79%. The method is simple and reproducible. It can be used for the determination of @entity2 in @entity0 plasma.

title: [Determination of XXXX in @entity0 plasma by microemulsion liquid chromatography].

answer: @entity2


abstract: A microemulsion liquid chromatographic (MELC) method was developed for the determination of @entity2 in @entity0 plasma. The assay was performed on a Hypersil BDS @entity5 column, and the effects of each component in the microemulsion mobile phase on the elution were investigated. The optimized microemulsion mobile phase consisted of 0.5% @entity1 containing 3.0% @entity3 , 0.8% @entity7 , 6.0% @entity6 . The flow rate was 1.0 mL/min, and the separation was operated at ambient temperature. The fluorescence excitation and emission wavelengths were 274 nm and 312 nm, respectively. The plasma samples were diluted with the mobile phase and centrifuged before injection. The calibration curve of @entity2 was linear within the range of 0.25 - 10 microg/mL. The method recoveries were (98.2 +/- 1.9)% - (104.6 +/- 2.2)%. The intra-day @entity4 ( @entity4 ) of peak area were 1.42% -2.43%, and the inter-day @entity4 were 2.75% - 4.79%. The method is simple and reproducible. It can be used for the determination of @entity2 in @entity0 plasma.

title: [Determination of @entity2 in XXXX plasma by microemulsion liquid chromatography].

answer: @entity0


abstract: PURPOSE: To assess noninvasively the @entity1 microenvironment of neck nodal metastases in @entity0 with @entity2 by investigating the relationship between @entity1 perfusion measured using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and @entity3 measured by @entity5 ( @entity4 -FMISO) positron emission tomography (PET). METHODS AND MATERIALS: Thirteen newly diagnosed @entity2 @entity0 with metastatic neck nodes underwent DCE-MRI and @entity4 -FMISO PET imaging before chemotherapy and radiotherapy. The matched regions of interests from both modalities were analyzed. To examine the correlations between DCE-MRI parameters and standard uptake value (SUV) measurements from @entity4 -FMISO PET, the nonparametric Spearman correlation coefficient was calculated. Furthermore, DCE-MRI parameters were compared between nodes with @entity4 -FMISO uptake and nodes with no @entity5 uptake using Mann-Whitney U tests. RESULTS: For the 13 @entity0 , a total of 18 nodes were analyzed. The nodal size strongly correlated with the @entity4 -FMISO SUV (rho = 0.74, p < 0.001). There was a strong negative correlation between the median k(ep) (redistribution rate constant) value (rho = -0.58, p = 0.042) and the @entity4 -FMISO SUV. @entity3 nodes (moderate to severe @entity5 uptake) had significantly lower median K(trans) (volume transfer constant) (p = 0.049) and median k(ep) (p = 0.027) values than did nonhypoxic nodes (no @entity5 uptake). CONCLUSION: This initial evaluation of the preliminary results support the hypothesis that in metastatic neck lymph nodes, @entity3 nodes are poorly perfused (i.e., have significantly lower K(trans) and k(ep) values) compared with nonhypoxic nodes.

title: Noninvasive assessment of @entity1 microenvironment using dynamic contrast-enhanced magnetic resonance imaging and XXXX positron emission tomography imaging in neck nodal metastases.

answer: @entity5


abstract: PURPOSE: To assess noninvasively the @entity1 microenvironment of neck nodal metastases in @entity0 with @entity2 by investigating the relationship between @entity1 perfusion measured using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and @entity3 measured by @entity5 ( @entity4 -FMISO) positron emission tomography (PET). METHODS AND MATERIALS: Thirteen newly diagnosed @entity2 @entity0 with metastatic neck nodes underwent DCE-MRI and @entity4 -FMISO PET imaging before chemotherapy and radiotherapy. The matched regions of interests from both modalities were analyzed. To examine the correlations between DCE-MRI parameters and standard uptake value (SUV) measurements from @entity4 -FMISO PET, the nonparametric Spearman correlation coefficient was calculated. Furthermore, DCE-MRI parameters were compared between nodes with @entity4 -FMISO uptake and nodes with no @entity5 uptake using Mann-Whitney U tests. RESULTS: For the 13 @entity0 , a total of 18 nodes were analyzed. The nodal size strongly correlated with the @entity4 -FMISO SUV (rho = 0.74, p < 0.001). There was a strong negative correlation between the median k(ep) (redistribution rate constant) value (rho = -0.58, p = 0.042) and the @entity4 -FMISO SUV. @entity3 nodes (moderate to severe @entity5 uptake) had significantly lower median K(trans) (volume transfer constant) (p = 0.049) and median k(ep) (p = 0.027) values than did nonhypoxic nodes (no @entity5 uptake). CONCLUSION: This initial evaluation of the preliminary results support the hypothesis that in metastatic neck lymph nodes, @entity3 nodes are poorly perfused (i.e., have significantly lower K(trans) and k(ep) values) compared with nonhypoxic nodes.

title: Noninvasive assessment of XXXX microenvironment using dynamic contrast-enhanced magnetic resonance imaging and @entity5 positron emission tomography imaging in neck nodal metastases.

answer: @entity1


abstract: Despite recent advances in diagnosis and treatment, overall survival of @entity0 with @entity3 floor continues to be low. Prognostic information is essential for improved evaluation and treatment. A molecular approach is necessary for a better understanding of @entity1 . We analyzed 50 @entity0 with early @entity3 (stages I and II - AJCC, 1997), who were surgically treated in head and neck departments at Heliopolis Hospital and Santa @entity5 in S  o Paulo, Brazil. We searched for epidemiological and pathological behaviors that could be involved in @entity1 recurrence and the influence of cellular adhesion loss in @entity0 outcome. We established two groups: @entity0 with disease recurrence within 3 years of follow-up and @entity0 with no @entity1 recurrence in this period. Significant prognostic variables included age, daily @entity2 intake, neural invasion and maximum @entity1 thickness. Our findings are similar to other published data in which younger @entity0 have a better prognosis. The odds ratio for neural invasion was low but was significant for thickness. No significant difference was observed among groups in @entity4 expression. Our data suggest that 3 and 5mm are the prognostic determinants of thickness. @entity4 mutation was not related to recurrences but was associated with locally aggressive invasion patterns.

title: Epidemiological and histopathological data and XXXX -like prognostic factors in early carcinomas of the tongue and floor of mouth.

answer: @entity4


abstract: OBJECTIVE: To confirm previous findings that hip abductor activity measured by electromyography (EMG) on the side contralateral to cane use is reduced during walking in @entity1 @entity0 . To assess whether an orthosis (TheraTogs) or hip abductor taping increase hemiplegic hip abductor activity compared with activity during cane walking or while walking without aids. To investigate the effect of each condition on temporo-spatial gait parameters. DESIGN: Randomized, within- @entity0 experimental study. SETTING: Gait laboratory. SUBJECTS: Thirteen @entity0 following first @entity1 . INTERVENTION: Data collection over six gait cycles as subjects walked at self-selected speed during: baseline (without aids) and in randomized order with (1) hip abductor taping, (2) TheraTogs, (3) cane in non-hemiplegic hand. MAIN MEASURES: Peak EMG of gluteus medius and @entity2 and temporo-spatial gait parameters. RESULTS: Cane use reduced EMG activity in gluteus medius from baseline by 21.86%. TheraTogs increased it by 16.47% (change cane use-TheraTogs P = 0.001, effect size = -0.5) and tape by 5.8% (change cane use-tape P = 0.001, effect size = -0.46). In @entity2 cane use reduced EMG activity from baseline by 19.14%. TheraTogs also reduced EMG activity from baseline by 1.10% (change cane use-TheraTogs P = 0.009, effect size -0.37) and tape by 3% (not significant). Gait speed (m/s) at: baseline 0.44, cane use 0.45, tape 0.48, TheraTogs 0.49. CONCLUSION: Hip abductor taping and TheraTogs increase hemiplegic hip abductor activity and gait speed during walking compared with baseline and cane use.

title: Hip abductor control in walking following XXXX -- the immediate effect of canes, taping and TheraTogs on gait.

answer: @entity1


abstract: OBJECTIVE: To clone and characterize the p43 cDNA from muscle larvae cDNA library of @entity3 (Ts) Chinese isolate. METHODS: PCR technique was used to amplify the target cDNA from muscle larvae cDNA library. After cloned in pMD18T vector, it was transformed into @entity1 NovaBlue. The positive clones were sequenced and the cDNA was cloned into pET28a expression vector. After induced by IPTG, the inclusion body of the recombinant protein was purified and re-natured. The deoxyribonuclease II (DNase II) activity of the recombinant protein was tested by hydrolyzing XDNA. RESULTS: Open reading frame (ORF) of the p43 cDNA was successfully cloned from the muscle larvae cDNA library of the Chinese Ts, there were mutations of two @entity2 in the ORF of the Chinese Ts p43 cDNA comparing with that from U.S.A. isolate at the positions 210 and 604, namely, C and A in the USA isolate but T and G in the Chinese isolate. Considering that three authors had cloned the same p43 cDNA from the USA isolate and six groups (including this team) had also obtained the same sequence from the Chinese isolate, the mutation of the two @entity2 was considered as the single nucleotide polymorphic (SNP) marker of the Chinese Ts isolate. The DNase II activity of the recombinant protein was successfully detected by hydrolyzing lamdaDNA. CONCLUSION: The p43 cDNA was successfully cloned from the muscle larvae cDNA library of the Ts Chinese isolate. Two SNPs were found in the @entity0 sequence. The DNase II activity was proved.

title: [Cloning and characterization of p43 cDNA from XXXX ].

answer: @entity3


abstract: Salinity affects normal growth and development of plants depending on their capacity to overcome the induced stress. The present study was focused on the response and regulation of the antioxidant defence system in @entity3 roots under short and long salt treatments. The function and the implications of @entity0 as a stressor or as a signalling molecule were also studied. Two different zones were analysed--the elongation and differentiation zone and the fully differentiated root zone--in order to broaden the knowledge of the different effects of salt stress in root. In general, an accumulation of @entity0 was observed in both zones at the highest (80 mM @entity1 ) concentration. A higher accumulation of @entity0 was observed in the stele of salt-treated roots. At the subcellular level, mitochondria accumulated @entity0 in salt-treated roots. The results confirm a drastic decrease in the antioxidant enzymes @entity5 , @entity4 peroxidase, and peroxidases under short salt treatments. However, @entity5 and peroxidase activities were recovered under long salt stress treatments. The two antioxidant molecules analysed, @entity4 and @entity2 , showed a different trend during salt treatments. @entity4 was progressively accumulated and its redox state maintained, but @entity2 was highly accumulated at 24 h of salt treatment, but then its concentration and redox state progressively decreased. Concomitantly, the antioxidant enzymes involved in @entity4 and @entity2 regeneration were modified under salt stress treatments. In conclusion, the increase in @entity4 levels and the maintenance of the redox state seem to be critical for root growth and development under salt stress.

title: A different role for XXXX and the antioxidative system under short and long salt stress in @entity3 roots.

answer: @entity0


abstract: Salinity affects normal growth and development of plants depending on their capacity to overcome the induced stress. The present study was focused on the response and regulation of the antioxidant defence system in @entity3 roots under short and long salt treatments. The function and the implications of @entity0 as a stressor or as a signalling molecule were also studied. Two different zones were analysed--the elongation and differentiation zone and the fully differentiated root zone--in order to broaden the knowledge of the different effects of salt stress in root. In general, an accumulation of @entity0 was observed in both zones at the highest (80 mM @entity1 ) concentration. A higher accumulation of @entity0 was observed in the stele of salt-treated roots. At the subcellular level, mitochondria accumulated @entity0 in salt-treated roots. The results confirm a drastic decrease in the antioxidant enzymes @entity5 , @entity4 peroxidase, and peroxidases under short salt treatments. However, @entity5 and peroxidase activities were recovered under long salt stress treatments. The two antioxidant molecules analysed, @entity4 and @entity2 , showed a different trend during salt treatments. @entity4 was progressively accumulated and its redox state maintained, but @entity2 was highly accumulated at 24 h of salt treatment, but then its concentration and redox state progressively decreased. Concomitantly, the antioxidant enzymes involved in @entity4 and @entity2 regeneration were modified under salt stress treatments. In conclusion, the increase in @entity4 levels and the maintenance of the redox state seem to be critical for root growth and development under salt stress.

title: A different role for @entity0 and the antioxidative system under short and long salt stress in XXXX roots.

answer: @entity3


abstract: OBJECTIVES: The treatment of @entity5 is challenging. Radiofrequency ablation has been increasingly applied in the management of @entity3 . Herein, we report our experience of radiofrequency ablation on 12 @entity0 with @entity5 . METHODS: From March 2006 to September 2010, 12 @entity0 with bilateral @entity5 (29 lesions overall) were identified from our kidney database. The mean age was 62.3 years (range 35-81). The mean @entity1 diameter was 4.5 cm (range 0.9-9.0). Three @entity0 received unilateral radiofrequency ablation and contralateral radical nephrectomy, whereas nine @entity0 received bilateral radiofrequency ablation. The oncological and functional outcomes were analyzed. Contrast-enhanced computed tomography examinations were carried out at day 7, and at 3 and 6 months after the procedure, and every 6 months thereafter. RESULTS: The mean follow-up period was 33 months (range 10-64). The @entity1 control rate was 93.1% (27/29). Cancer-specific survival and the overall survival rates were 100%. No death or @entity2 after the procedure was found. In @entity0 who underwent bilateral radiofrequency ablation, the latest mean glomerular filtration rate had not significantly declined compared with preoperative levels (93.7    13.0 mL/ @entity4 .73 m(2) vs 96.9    13.3 mL/ @entity4 .73 m(2), respectively; P > 0.05). CONCLUSION: Radiofrequency ablation shows encouraging outcomes in the treatment of @entity5 . It can provide adequate @entity1 control and @entity1 -specific survival compared with nephron-sparing surgery while not affecting the renal function.

title: Radiofrequency ablation of XXXX .

answer: @entity5


abstract: CONTEXT: @entity0 has characteristic cytologic features, but few studies exist that analyze the reproducibility of this diagnosis. OBJECTIVE: To analyze @entity1 ' diagnosis of @entity4 in breast fine-needle aspiration (FNA) slides distributed in an educational interlaboratory peer comparison program. DESIGN: @entity1 responses for FNA slides with a reference diagnosis of @entity4 , distributed between 2001-2008 in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology, were evaluated for concordance with the general category and reference diagnosis of @entity4 . RESULTS: Of 8061 responses, 6353 (78.8%) were categorized as malignant; 775 (9.6%) as suspicious; and 933 (11.6%) as negative. The most frequent incorrect responses for the benign category included @entity5 (51.7%), nonspecified @entity3 (12%), @entity7 (7.8%), and fat @entity2 / @entity6 / @entity8 (6.9%). Conventional Papanicolaou-stained preparations were reviewed for 58.7% (4732) of responses; of these, 39.4% (3177) were from modified Giemsa-stained smears and 1.9% (152) from ThinPrep slides. Papanicolaou-stained conventional smears had the lowest concordance (86.5%) when compared to modified Giemsa-stained smears (91.2%) and ThinPrep challenges (92.1%) (P < .001). @entity1 specifically diagnosed @entity4 37.3% of the time, and modified Giemsa-stained challenges performed best (43.1%, P < .001). There was no significant difference between cytotechnologists' and pathologists' responses (87.9% versus 88.2%; P = .69). CONCLUSIONS: @entity4 in FNA was not accurately identified in a glass slide interlaboratory comparison program. We observed better performance with modified Giemsa-stained and ThinPrep slides than with Papanicolaou-stained preparations. The most common response for the benign category of @entity4 was @entity5 . Increased awareness of the cytologic features of @entity4 may improve accuracy in breast FNA.

title: Performance characteristics of mucinous (colloid) XXXX in fine-needle aspirates: observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology.

answer: @entity0


abstract: There is evidence that inflammatory processes are involved in the development and/or progression of @entity11 . However, effective treatment for @entity3 in the kidneys of @entity1 is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the @entity7 @entity13 ( @entity13 ) may reduce @entity3 in @entity0 with @entity1 kidneys. @entity12 -induced @entity1 @entity4 were randomly assigned to two groups treated with a gavage of either @entity13 or vehicle. A group of non- @entity1 control @entity4 was treated concurrently. Compared with vehicle-treated @entity1 @entity4 , @entity13 -treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of @entity6 ( @entity6 ) and @entity10 . This was associated with attenuation of the structural and functional abnormalities of early @entity11 , such as @entity2 , mesangial expansion, and @entity5 . Administration of @entity13 significantly reduced @entity8 oxidase-dependent superoxide generation and decreased expression of @entity9 and advanced oxidation protein products in @entity1 kidney. These data suggest that @entity13 might improve @entity11 , probably through inhibition of redox-sensitive @entity3 .

title: @entity7 extraction of Picrorhiza scrophulariiflora prevents XXXX in experimental @entity1 via anti- @entity3 action.

answer: @entity2


abstract: There is evidence that inflammatory processes are involved in the development and/or progression of @entity11 . However, effective treatment for @entity3 in the kidneys of @entity1 is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the @entity7 @entity13 ( @entity13 ) may reduce @entity3 in @entity0 with @entity1 kidneys. @entity12 -induced @entity1 @entity4 were randomly assigned to two groups treated with a gavage of either @entity13 or vehicle. A group of non- @entity1 control @entity4 was treated concurrently. Compared with vehicle-treated @entity1 @entity4 , @entity13 -treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of @entity6 ( @entity6 ) and @entity10 . This was associated with attenuation of the structural and functional abnormalities of early @entity11 , such as @entity2 , mesangial expansion, and @entity5 . Administration of @entity13 significantly reduced @entity8 oxidase-dependent superoxide generation and decreased expression of @entity9 and advanced oxidation protein products in @entity1 kidney. These data suggest that @entity13 might improve @entity11 , probably through inhibition of redox-sensitive @entity3 .

title: @entity7 extraction of Picrorhiza scrophulariiflora prevents @entity2 in experimental XXXX via anti- @entity3 action.

answer: @entity1


abstract: There is evidence that inflammatory processes are involved in the development and/or progression of @entity11 . However, effective treatment for @entity3 in the kidneys of @entity1 is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the @entity7 @entity13 ( @entity13 ) may reduce @entity3 in @entity0 with @entity1 kidneys. @entity12 -induced @entity1 @entity4 were randomly assigned to two groups treated with a gavage of either @entity13 or vehicle. A group of non- @entity1 control @entity4 was treated concurrently. Compared with vehicle-treated @entity1 @entity4 , @entity13 -treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of @entity6 ( @entity6 ) and @entity10 . This was associated with attenuation of the structural and functional abnormalities of early @entity11 , such as @entity2 , mesangial expansion, and @entity5 . Administration of @entity13 significantly reduced @entity8 oxidase-dependent superoxide generation and decreased expression of @entity9 and advanced oxidation protein products in @entity1 kidney. These data suggest that @entity13 might improve @entity11 , probably through inhibition of redox-sensitive @entity3 .

title: XXXX extraction of Picrorhiza scrophulariiflora prevents @entity2 in experimental @entity1 via anti- @entity3 action.

answer: @entity7


abstract: There is evidence that inflammatory processes are involved in the development and/or progression of @entity11 . However, effective treatment for @entity3 in the kidneys of @entity1 is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the @entity7 @entity13 ( @entity13 ) may reduce @entity3 in @entity0 with @entity1 kidneys. @entity12 -induced @entity1 @entity4 were randomly assigned to two groups treated with a gavage of either @entity13 or vehicle. A group of non- @entity1 control @entity4 was treated concurrently. Compared with vehicle-treated @entity1 @entity4 , @entity13 -treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of @entity6 ( @entity6 ) and @entity10 . This was associated with attenuation of the structural and functional abnormalities of early @entity11 , such as @entity2 , mesangial expansion, and @entity5 . Administration of @entity13 significantly reduced @entity8 oxidase-dependent superoxide generation and decreased expression of @entity9 and advanced oxidation protein products in @entity1 kidney. These data suggest that @entity13 might improve @entity11 , probably through inhibition of redox-sensitive @entity3 .

title: @entity7 extraction of Picrorhiza scrophulariiflora prevents @entity2 in experimental @entity1 via anti- XXXX action.

answer: @entity3


abstract: BACKGROUND: @entity6 nasal spray (MFNS) 400 microg, twice daily, as adjunctive treatment with oral antibiotic significantly improved symptoms of recurrent rhinosinusitis. OBJECTIVE: To evaluate the effectiveness and safety of MFNS 200 microg, twice daily, and 400 microg, twice daily, compared with placebo as adjunctive treatment with oral antibiotic for acute rhinosinusitis. METHODS: In this multicenter, double-blind, placebo-controlled study, 967 outpatients with computed tomographic scan-confirmed moderate to severe rhinosinusitis received @entity1 / @entity3 ( @entity5 , GlaxoSmithKline, Research Triangle Park, NC) 875 mg, twice daily, for 21 days with adjunctive twice daily MFNS 200 microg, MFNS 400 microg, or placebo nasal spray. @entity0 recorded scores of six rhinosinusitis symptoms and any adverse events twice daily. Pre- and postcosyntropin-stimulation plasma @entity2 levels were measured in a subset of @entity0 at selected study sites. RESULTS: Treatment with MFNS 200 microg or 400 microg, twice daily, produced significantly greater improvements in total symptoms score (primary efficacy variable) day 1 to day 15 average (50% and 51%, respectively) than placebo (44%, P < or = 0.017). Both doses of MFNS produced significant total symptoms score improvement over placebo by day 4, and maintained efficacy over the entire 21-day study. Relief of individual symptoms showed a similar pattern. Both doses of MFNS were well tolerated, and adverse events were similar to that of placebo. Cosyntropin stimulation showed no evidence of @entity4 suppression. CONCLUSIONS: As adjunctive therapy to oral antibiotic treatment, MFNS at doses of 200 microg or 400 microg, twice daily, was well tolerated and significantly more effective in reducing the symptoms of rhinosinusitis than antibiotic therapy alone.

title: Effective dose range of XXXX nasal spray in the treatment of acute rhinosinusitis.

answer: @entity6


abstract: OBJECTIVE: To report the 5-year experience of a diagnostic programme for @entity3 with special emphasis to diagnose hormonally active and @entity1 . DESIGN: A prospective study in which new cases of @entity3 in Sweden have been evaluated by a standardized diagnostic protocol between January 1996 and July 2001. SETTING: Thirty-three different Swedish hospitals have contributed with cases. SUBJECTS: A total of 381 @entity0 (217 females, 164 males) with @entity3 were studied. INTERVENTIONS: Diagnostic procedures were undertaken according to a standardized programme. Operation was recommended if the incidentaloma had a size of more than 3-4 cm or if there was a suspicion of a hypersecreting @entity1 . MAIN OUTCOME MEASURES: The size of the incidentaloma, clinical characteristics of the @entity0 and results of biochemical diagnostic tests were registered. RESULTS: The median age of the @entity0 was 64 years (18-84 years), and the median size of the incidentalomas was 3 cm (1-20 cm). A total of 85(22%) @entity0 were operated. Twenty of these @entity0 were diagnosed with a benign hypersecreting @entity1 and 14 with a @entity1 . Fourteen of 15 operated @entity0 with diagnosed @entity7 had elevated 24-h urinary @entity5 and all of the @entity0 operated because of a biochemical suspicion of @entity6 or @entity4 hypersecretion (n = 6) were found to have @entity2 . Of the 14 operated @entity0 with @entity1 , 10 were @entity8 (median size 10 cm; range 4-16 cm). In a multiple logistic regression model, incidentaloma size was significantly associated with the risk of a @entity1 (P = 0.009), and there was a tendency of an association between age/male sex and the risk of a @entity1 (both, P = 0.07). CONCLUSION: In this Swedish multicentre study of 381 cases with @entity3 , 5% had benign hypersecreting @entity1 and nearly 4% had @entity1 . The results of the biochemical diagnostic tests used had a high compatibility with the histological diagnosis found at operation in the @entity0 with hypersecreting @entity1 . @entity1 size, male gender and high age were predictive for the risk of a @entity1 . A follow-up of the @entity0 is warranted in order to establish whether there are undiscovered cases of malignant or hypersecreting @entity1 amongst the nonoperated @entity0 .

title: XXXX --experience of a standardized diagnostic programme in the Swedish prospective study.

answer: @entity3


abstract: OBJECTIVES: Several methods for measuring @entity6 ( @entity8 ) concentrations have been reported. However, these methods are not practical because they are either too complicated and/or too time-consuming for @entity8 determinations in human serum and plasma. DESIGN AND METHODS: We have developed a new enzymatic @entity8 assay, which uses lysophospholipase, @entity7 phosphodiesterase and @entity2 oxidase, and which determines the quantities of @entity0 generated in the presence of peroxidase using an oxidative chromogenic reagent and @entity9 . RESULTS: Various samples were mixed with @entity8 assay reagents, and their changes in absorbance were measured. The present method produced a linear calibration line between @entity8 concentration and absorbance change. It also measured only @entity8 , and not other phospholipids such as @entity3 , @entity4 and @entity5 . The within-run and between-run coefficients of variation were 0.3-0.7% and 0.7%, respectively. The recovery of exogenous @entity8 added to control serum was 99.5-102.1%. The correlation coefficient obtained in a comparison with a method for analyzing @entity1 was 0.9122. CONCLUSIONS: The present method is simple, specific for @entity8 , and can be applied with an automatic analyzer. It may also be useful for further studies of the biological functions of @entity8 as well as clinical applications in various disorders.

title: An enzymatic assay for XXXX concentration in human serum and plasma.

answer: @entity6


abstract: BACKGROUND: We hypothesized that delineating electrically unexcitable scar (EUS) within low-voltage @entity2 regions will locate reentry circuit isthmuses by defining their borders. The pacing threshold and electrogram amplitude that best determines EUS is unknown. METHODS AND RESULTS: The change in dimension of the virtual electrode was estimated in 11 @entity0 and observed to increase by 4.4+/-2.5 mm as stimulus strength increases from threshold (2.9+/-1.8 mA) to 10 mA. EUS was defined as a threshold >10 mA. In 14 consecutive @entity0 , mapping and ablation of @entity1 ( @entity1 ) were performed using an electroanatomic mapping system. During sinus rhythm, unipolar pacing was performed at sites with bipolar electrogram amplitude <1.5 mV. EUS regions were marked on the maps. Reentry circuit isthmuses were identified by entrainment mapping or pace mapping, and ablation was performed. EUS was identified in the @entity2 in all 14 @entity0 (11.8+/-13.9 cm2). All 20 @entity1 circuit isthmuses identified were adjacent to EUS. Although electrogram amplitude correlated with pacing threshold (r=0.64, P<0.0001), many isthmuses had very low-amplitude electrograms, and EUS could not be identified from electrogram amplitude alone. RF ablation lines connecting selected EUS regions abolished all inducible VTs in 10 @entity0 (71%); spontaneous @entity1 was markedly reduced during follow-up (from 142+/-360 to 0.9+/-2.0 episodes per month, P=0.002). CONCLUSIONS: This new method of identifying EUS provides complimentary information to the electrogram amplitude in delineating potential reentry circuit paths, potentially facilitating ablation during sinus rhythm.

title: Electrically unexcitable scar mapping based on pacing threshold for identification of the reentry circuit isthmus: feasibility for guiding XXXX .

answer: @entity1


abstract: BACKGROUND: MicroRNAs (miRs) are a class of short RNA molecules, which negatively regulate gene expression. The levels of circulating miR-15 family members are elevated in septic @entity0 and may be associated with @entity2 . This study investigated whether inhibition of @entity7 , a member of the miR-15 family, provided beneficial effects in @entity3 . METHODS AND RESULTS: @entity3 was induced by injection of feces into the peritoneum in @entity1 . @entity7 was upregulated in the lung and liver of septic @entity1 . Silencing of @entity7 increased the protein levels of @entity5 , @entity8 , and @entity6 ; prevented apoptosis; reduced liver and @entity4 ; and improved the survival in septic @entity1 . Silencing of @entity7 provided similar protection in lipopolysaccharide-induced endotoxemic @entity1 . In endothelial cells, upregulation of @entity7 induced apoptosis, and inhibition of @entity7 prevented lipopolysaccharide-induced apoptosis. @entity7 repressed expression of its protein targets, @entity5 , @entity8 , and @entity6 . Furthermore, overexpression of @entity6 prevented apoptosis induced by lipopolysaccharide and @entity7 mimic. Inhibition of @entity6 attenuated the protective effects of @entity7 silencing in septic @entity1 . CONCLUSIONS: Silencing of @entity7 reduced multiple-organ injury and improved the survival in @entity3 , and the protective effects of @entity7 inhibition were associated with upregulation of @entity5 , @entity8 , and @entity6 . Thus, inhibition of @entity7 may represent a new therapeutic approach for @entity3 .

title: Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in @entity1 Models of XXXX .

answer: @entity3


abstract: BACKGROUND: MicroRNAs (miRs) are a class of short RNA molecules, which negatively regulate gene expression. The levels of circulating miR-15 family members are elevated in septic @entity0 and may be associated with @entity2 . This study investigated whether inhibition of @entity7 , a member of the miR-15 family, provided beneficial effects in @entity3 . METHODS AND RESULTS: @entity3 was induced by injection of feces into the peritoneum in @entity1 . @entity7 was upregulated in the lung and liver of septic @entity1 . Silencing of @entity7 increased the protein levels of @entity5 , @entity8 , and @entity6 ; prevented apoptosis; reduced liver and @entity4 ; and improved the survival in septic @entity1 . Silencing of @entity7 provided similar protection in lipopolysaccharide-induced endotoxemic @entity1 . In endothelial cells, upregulation of @entity7 induced apoptosis, and inhibition of @entity7 prevented lipopolysaccharide-induced apoptosis. @entity7 repressed expression of its protein targets, @entity5 , @entity8 , and @entity6 . Furthermore, overexpression of @entity6 prevented apoptosis induced by lipopolysaccharide and @entity7 mimic. Inhibition of @entity6 attenuated the protective effects of @entity7 silencing in septic @entity1 . CONCLUSIONS: Silencing of @entity7 reduced multiple-organ injury and improved the survival in @entity3 , and the protective effects of @entity7 inhibition were associated with upregulation of @entity5 , @entity8 , and @entity6 . Thus, inhibition of @entity7 may represent a new therapeutic approach for @entity3 .

title: Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in XXXX Models of @entity3 .

answer: @entity1


abstract: BACKGROUND: Bariatric surgery has been established as the most effective long-term treatment for morbid @entity1 and @entity1 -related comorbidities. Despite its success, there is a paucity of data on the outcomes of bariatric surgery on Hispanic @entity0 . STUDY DESIGN: We performed a retrospective review of @entity1 @entity0 treated at our institute between 2008 and 2014. We identified self-reported Hispanic @entity0 who underwent a laparoscopic gastric bypass (LGBP), sleeve gastrectomy (LSG), or gastric band (LGB) procedure. The primary end point was excess @entity2 (EWL) at 6, 12, 24, and 36 months. Secondary end points included improvement of @entity1 -related metabolic parameters at 1 year. We performed a repeated measures analysis of variance to calculate statistical significance throughout our study time period. RESULTS: We identified 2002 Hispanic @entity0 who underwent bariatric surgery (1,235 LGBP, 600 LSG, 167 LGB) at our institute from 2008 to 2014. Follow-ups at 6, 12, 24, and 36 months were 62.2%, 54.5%, 36.2%, and 19.8%, respectively. Mean preoperative BMIs were 47.0    7.2 kg/m(2), 46.1    7.8 kg/m(2), and 44.9    6.0 kg/m(2) for the LGBP, LSG, and LGB cohorts, respectively. Excess @entity2 was significantly more pronounced in the LGBP and the LSG groups than in the LGB group; this difference was accentuated over time (Fig.  1; p  < 0.0001). Obesity-related metabolic parameters and the need for comorbidity medical therapy decreased in all 3 surgical groups. CONCLUSIONS: Bariatric surgery is highly successful in @entity1 @entity0 . In the largest series to date, LGBP and LSG seem to yield more effective EWL and @entity2 parameters than LGB among Hispanics; however, outcomes are still markedly reduced when compared with those in non-Hispanic populations.

title: Excess Weight Loss and Cardiometabolic Parameter Reduction Diminished among Hispanics Undergoing Bariatric Surgery: Outcomes in More than 2,000 Consecutive Hispanic XXXX at a Single Institution.

answer: @entity0


abstract: PURPOSE: Incidence of anterior knee @entity1 after total knee arthroplasty (TKA) is reported to be between 4 and 49  %. The incidence of AKP at long-term follow-up and possible determinants after cruciate cruciate-retaining TKA were investigated. METHODS: A 10-year follow-up of a cohort of 55 @entity0 (63 TKAs), who received the balanSys    cruciate-retaining total knee system (Mathys Ltd, Bettlach, Switzerland) between 1999 and 2002, was performed. @entity0 had undergone the balanced gap technique, with either a fixed bearing or an AP-glide bearing. Standardised diagnostic questions regarding AKP were collected and categorised into two groups: those with and without AKP. The lateral patellar tilt, patellar displacement measurement and modified Insall-Salvati ratio were used for patella position evaluation on skyline radiographs. The Knee Society Score (KSS), the @entity2 Outcome Score (KOOS) and Numerical Rating Scales (NRS) for @entity1 and satisfaction were obtained at follow-up. RESULTS: Sixteen @entity0 in the study population experienced AKP. Incidence of AKP (fixed bearing 13/44; AP-glide bearing baring 3/17) was not dependent on type of insert (n.s.). There were no statistical differences in patella position and tibiofemoral contact point between the AKP group and the no AKP group (n.s.). KSS, KOOS, NRS- @entity1 and NRS-satisfaction were significantly lower for the @entity0 with AKP (all p  <  0.05). CONCLUSION: Twenty-six percentage of the @entity0 experienced AKP 10  years after balanced gap TKA. Postoperative patella positioning was not found to be a determinant for anterior knee @entity1 after TKA. However, patellar displacement does not seem completely favourable. Moreover, type of bearing was not found a determinant for AKP at long-term follow-up. LEVEL OF EVIDENCE: Lower quality prospective cohort study (<80  % follow-up, @entity0 enrolled at different time points in disease), Level II.

title: Patella position is not a determinant for anterior knee XXXX 10  years after balanced gap total knee arthroplasty.

answer: @entity1


abstract: @entity5 is a common @entity1 of the genital tract. In the present study, we examined the expression of @entity0 @entity4 ( @entity4 ) protein, @entity11 ( @entity11 ), 17alpha-hydroxylase/17,20-desmolase (P45017alpha) and aromatase (P450 arom) in @entity5 cells to clarify the ability of these cells to produce @entity2 hormones. The results of RT-PCR analysis showed that @entity4 , @entity11 and P45017alpha genes were expressed in @entity5 cells. To examine the protein expression of @entity4 and @entity11 , we performed Western blotting using extracts from @entity3 cells. @entity4 protein and @entity11 were detected in both HHUA and HOUA-1 cells. The production of @entity9 in HHUA cells increased 2.4-fold with transfection of a @entity4 expression vector and 4.3-fold with transfection of an F2 side-chain cleavage system. The RT-PCR product of @entity7 dehydrogenase was present in @entity5 cells. In @entity5 cells, the production of @entity6 also increased with over-expression of @entity4 and the F2 system. Results of @entity2 metabolic assays showed that @entity5 cells produced not only @entity10 but also @entity8 . @entity5 cells express enzymes that are associated with the production of @entity2 hormones. Locally produced @entity2 hormones may have effects on @entity1 proliferation and tumorigenesis.

title: Expression of enzyme associated with XXXX hormone synthesis and local production of @entity2 hormone in @entity5 cells.

answer: @entity2


abstract: @entity5 is a common @entity1 of the genital tract. In the present study, we examined the expression of @entity0 @entity4 ( @entity4 ) protein, @entity11 ( @entity11 ), 17alpha-hydroxylase/17,20-desmolase (P45017alpha) and aromatase (P450 arom) in @entity5 cells to clarify the ability of these cells to produce @entity2 hormones. The results of RT-PCR analysis showed that @entity4 , @entity11 and P45017alpha genes were expressed in @entity5 cells. To examine the protein expression of @entity4 and @entity11 , we performed Western blotting using extracts from @entity3 cells. @entity4 protein and @entity11 were detected in both HHUA and HOUA-1 cells. The production of @entity9 in HHUA cells increased 2.4-fold with transfection of a @entity4 expression vector and 4.3-fold with transfection of an F2 side-chain cleavage system. The RT-PCR product of @entity7 dehydrogenase was present in @entity5 cells. In @entity5 cells, the production of @entity6 also increased with over-expression of @entity4 and the F2 system. Results of @entity2 metabolic assays showed that @entity5 cells produced not only @entity10 but also @entity8 . @entity5 cells express enzymes that are associated with the production of @entity2 hormones. Locally produced @entity2 hormones may have effects on @entity1 proliferation and tumorigenesis.

title: Expression of enzyme associated with @entity2 hormone synthesis and local production of XXXX hormone in @entity5 cells.

answer: @entity2


abstract: @entity5 is a common @entity1 of the genital tract. In the present study, we examined the expression of @entity0 @entity4 ( @entity4 ) protein, @entity11 ( @entity11 ), 17alpha-hydroxylase/17,20-desmolase (P45017alpha) and aromatase (P450 arom) in @entity5 cells to clarify the ability of these cells to produce @entity2 hormones. The results of RT-PCR analysis showed that @entity4 , @entity11 and P45017alpha genes were expressed in @entity5 cells. To examine the protein expression of @entity4 and @entity11 , we performed Western blotting using extracts from @entity3 cells. @entity4 protein and @entity11 were detected in both HHUA and HOUA-1 cells. The production of @entity9 in HHUA cells increased 2.4-fold with transfection of a @entity4 expression vector and 4.3-fold with transfection of an F2 side-chain cleavage system. The RT-PCR product of @entity7 dehydrogenase was present in @entity5 cells. In @entity5 cells, the production of @entity6 also increased with over-expression of @entity4 and the F2 system. Results of @entity2 metabolic assays showed that @entity5 cells produced not only @entity10 but also @entity8 . @entity5 cells express enzymes that are associated with the production of @entity2 hormones. Locally produced @entity2 hormones may have effects on @entity1 proliferation and tumorigenesis.

title: Expression of enzyme associated with @entity2 hormone synthesis and local production of @entity2 hormone in XXXX cells.

answer: @entity5


abstract: PURPOSE: To evaluate intracameral injection of mydriatics in phacoemulsification @entity3 surgery and compare the results with those of conventional topical mydriatics. SETTING: Department of Clinical Science/Ophthalmology, Ume   University Hospital, Ume  , Sweden. METHODS: This prospective randomized double-blind study included 60 @entity0 who were given topical (topical group) or intracameral (intracameral group) mydriatics. The topical mydriatics comprised 3 drops of @entity7 1% and @entity4 10% given 15 minutes apart and 150 microL intracameral @entity5 1% ( @entity5 ) and the intracameral mydriatics, placebo eyedrops and 150 microL intracameral cyclopentolate 0.1%, @entity4 1.5%, and @entity5 1%. The pupil size was recorded preoperatively, throughout surgery, and 1 day and 1 month postoperatively. Preoperative and postoperative corneal endothelial morphology, corneal thickness, intraocular pressure, visual acuity, aqueous cells and flare, phacoemulsification energy, duration of surgery, pulse, blood pressure, and intraoperative sensation of @entity2 and glare were also recorded. RESULTS: With intracameral mydriatics, @entity6 reached 95% +/- 3% (SD) of its final value within 20 seconds. In the intracameral group, the pupils were smaller than in the topical group (mean 6.7 +/- 1.0 mm versus 7.7 +/- 1.0 mm, P<.001) but did not contract intraoperatively. The pupils in the topical group tended to contract, and the difference between groups was significant (P =.0020). The intracameral group reported less glare during the procedure (P<.001). There was no difference in endothelial cell loss, inflammatory reaction, postoperative @entity1 , or surgical performance between the groups. CONCLUSIONS: Intracameral mydriatics were a rapid, effective, and safe alternative to topical mydriatics in phacoemulsification. Their use can simplify preoperative routines and in certain high-risk groups, may reduce the risk for cardiovascular side effects.

title: Intracameral mydriatics in phacoemulsification XXXX surgery.

answer: @entity3


abstract: BACKGROUND: Although a considerable part of @entity0 desire further improvement in penile size after @entity2 repairs, @entity1 is only considered in @entity0 with @entity1 or acquired penile retraction. Modified @entity1 by free dermal-fat graft is introduced to satisfy these @entity0 and improve surgical safety. METHODS: From April 2012 to December 2014, a total of 15 male adults after @entity2 repairs, aged 18-24  years, underwent modified @entity1 which involved girth enhancement by a free dermal-fat graft and penile elongation (suprapubic skin advancement-ligamentolysis). A specially designed tunneling instrument was introduced to facilitate pericavernous thickening without degloving. Outcome evaluation was mainly based on objective penile measurements and results of the Male Genital Image Scale. RESULTS: With 6 months' follow-up, all @entity0 had achieved excellent cosmetic results, with a significant average dimensional increase of 1.53      0.23  cm in flaccid girth and 1.67      0.24  cm in flaccid length. No erection @entity3 occurred. @entity0 ' perception of male genitalia improved postoperatively, with the average MGIS score rising from 31.73      4.86 to 40.20      4.54. CONCLUSIONS: This modified technique is safe and effective in enlarging penile size. The use of the specially designed tunneling instrument simplifies penile girth enhancement, avoiding unnecessary trauma to the neo-urethra and neurovascular bundle. It is confirmed that physical dimensional enhancement does contribute to improving their underestimation of penile size. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

title: Modified Penile Augmentation by Dermal-Fat Graft in Post- XXXX Adults.

answer: @entity2


abstract: OBJECTIVE: To study the effect of low intensity pulsed ultrasound (LIPUS) on the expression of @entity3 ( @entity3 ) in the serum and expression of @entity4 ( @entity4 ) in the articular cartilage cells of @entity0 with @entity2 ( @entity1 ). METHODS: Inner patellar ligament defect method was used to establish the model of knee @entity1 . Four weeks after the modeling, the arterial blood was drawn from the ear of each @entity0 , while ELISA was employed to detect the expression of @entity3 in the serum. The chondrocytes were separated from animals in each group and then cultured in  vitro. All @entity0 were divided into control group, @entity1 model group and @entity1  +  LIPUS group. Cells in the control and @entity1 groups were not treated, while cells in the @entity1  +  LIPUS group were treated with LIPUS (40  mW/cm(2), 1 time/day). Cells were collected 7  d later and the RNA and total protein were extracted respectively. Real-time PCR and Western blotting were employed to analyze the expression of @entity4 in chondrocytes at the mRNA and protein level, respectively. RESULTS: The success rate of establishment of @entity1 model was 83%. The results of ELISA showed that the content of @entity3 in the serum of animals with @entity1 was 22.3%, lower than the one in the control group (P  <  0.05). Compared with the normal control group, the expression of @entity3 in the @entity1 model group was significantly increased, while the expression of @entity4 was significantly increased (P  <  0.05). After the stimulation of LIPUS, the expression of @entity3 and @entity4 was close to the one in the normal control group. CONCLUSIONS: The inner patellar ligament defect method is a mature method to establish the @entity0 @entity1 model, with high success rate. The expression of serum @entity3 in the @entity1 model group is significantly decreased. LIPUS can up-regulate @entity3 and down-regulate @entity4 .

title: Effect of low intensity pulsed ultrasound on expression of @entity3 in serum and expression of @entity4 in articular cartilage of @entity0 with XXXX .

answer: @entity2


abstract: OBJECTIVE: To study the effect of low intensity pulsed ultrasound (LIPUS) on the expression of @entity3 ( @entity3 ) in the serum and expression of @entity4 ( @entity4 ) in the articular cartilage cells of @entity0 with @entity2 ( @entity1 ). METHODS: Inner patellar ligament defect method was used to establish the model of knee @entity1 . Four weeks after the modeling, the arterial blood was drawn from the ear of each @entity0 , while ELISA was employed to detect the expression of @entity3 in the serum. The chondrocytes were separated from animals in each group and then cultured in  vitro. All @entity0 were divided into control group, @entity1 model group and @entity1  +  LIPUS group. Cells in the control and @entity1 groups were not treated, while cells in the @entity1  +  LIPUS group were treated with LIPUS (40  mW/cm(2), 1 time/day). Cells were collected 7  d later and the RNA and total protein were extracted respectively. Real-time PCR and Western blotting were employed to analyze the expression of @entity4 in chondrocytes at the mRNA and protein level, respectively. RESULTS: The success rate of establishment of @entity1 model was 83%. The results of ELISA showed that the content of @entity3 in the serum of animals with @entity1 was 22.3%, lower than the one in the control group (P  <  0.05). Compared with the normal control group, the expression of @entity3 in the @entity1 model group was significantly increased, while the expression of @entity4 was significantly increased (P  <  0.05). After the stimulation of LIPUS, the expression of @entity3 and @entity4 was close to the one in the normal control group. CONCLUSIONS: The inner patellar ligament defect method is a mature method to establish the @entity0 @entity1 model, with high success rate. The expression of serum @entity3 in the @entity1 model group is significantly decreased. LIPUS can up-regulate @entity3 and down-regulate @entity4 .

title: Effect of low intensity pulsed ultrasound on expression of @entity3 in serum and expression of @entity4 in articular cartilage of XXXX with @entity2 .

answer: @entity0


abstract: OBJECTIVE: To study the effect of low intensity pulsed ultrasound (LIPUS) on the expression of @entity3 ( @entity3 ) in the serum and expression of @entity4 ( @entity4 ) in the articular cartilage cells of @entity0 with @entity2 ( @entity1 ). METHODS: Inner patellar ligament defect method was used to establish the model of knee @entity1 . Four weeks after the modeling, the arterial blood was drawn from the ear of each @entity0 , while ELISA was employed to detect the expression of @entity3 in the serum. The chondrocytes were separated from animals in each group and then cultured in  vitro. All @entity0 were divided into control group, @entity1 model group and @entity1  +  LIPUS group. Cells in the control and @entity1 groups were not treated, while cells in the @entity1  +  LIPUS group were treated with LIPUS (40  mW/cm(2), 1 time/day). Cells were collected 7  d later and the RNA and total protein were extracted respectively. Real-time PCR and Western blotting were employed to analyze the expression of @entity4 in chondrocytes at the mRNA and protein level, respectively. RESULTS: The success rate of establishment of @entity1 model was 83%. The results of ELISA showed that the content of @entity3 in the serum of animals with @entity1 was 22.3%, lower than the one in the control group (P  <  0.05). Compared with the normal control group, the expression of @entity3 in the @entity1 model group was significantly increased, while the expression of @entity4 was significantly increased (P  <  0.05). After the stimulation of LIPUS, the expression of @entity3 and @entity4 was close to the one in the normal control group. CONCLUSIONS: The inner patellar ligament defect method is a mature method to establish the @entity0 @entity1 model, with high success rate. The expression of serum @entity3 in the @entity1 model group is significantly decreased. LIPUS can up-regulate @entity3 and down-regulate @entity4 .

title: Effect of low intensity pulsed ultrasound on expression of XXXX in serum and expression of @entity4 in articular cartilage of @entity0 with @entity2 .

answer: @entity3


abstract: OBJECTIVE: To study the effect of low intensity pulsed ultrasound (LIPUS) on the expression of @entity3 ( @entity3 ) in the serum and expression of @entity4 ( @entity4 ) in the articular cartilage cells of @entity0 with @entity2 ( @entity1 ). METHODS: Inner patellar ligament defect method was used to establish the model of knee @entity1 . Four weeks after the modeling, the arterial blood was drawn from the ear of each @entity0 , while ELISA was employed to detect the expression of @entity3 in the serum. The chondrocytes were separated from animals in each group and then cultured in  vitro. All @entity0 were divided into control group, @entity1 model group and @entity1  +  LIPUS group. Cells in the control and @entity1 groups were not treated, while cells in the @entity1  +  LIPUS group were treated with LIPUS (40  mW/cm(2), 1 time/day). Cells were collected 7  d later and the RNA and total protein were extracted respectively. Real-time PCR and Western blotting were employed to analyze the expression of @entity4 in chondrocytes at the mRNA and protein level, respectively. RESULTS: The success rate of establishment of @entity1 model was 83%. The results of ELISA showed that the content of @entity3 in the serum of animals with @entity1 was 22.3%, lower than the one in the control group (P  <  0.05). Compared with the normal control group, the expression of @entity3 in the @entity1 model group was significantly increased, while the expression of @entity4 was significantly increased (P  <  0.05). After the stimulation of LIPUS, the expression of @entity3 and @entity4 was close to the one in the normal control group. CONCLUSIONS: The inner patellar ligament defect method is a mature method to establish the @entity0 @entity1 model, with high success rate. The expression of serum @entity3 in the @entity1 model group is significantly decreased. LIPUS can up-regulate @entity3 and down-regulate @entity4 .

title: Effect of low intensity pulsed ultrasound on expression of @entity3 in serum and expression of XXXX in articular cartilage of @entity0 with @entity2 .

answer: @entity4


abstract: BACKGROUND: Modified endoscopic procedures for @entity1 ( @entity1 ) have a greater success rate because of the increased number of linear lesions. Concerns have been raised about the impact of ablation scars on the left atrium. This study aimed to examine the impact of ablation on left atrial dimension and systolic function after modified endoscopic procedures with echocardiographic measurement. METHODS: Of 107 @entity0 undergoing modified endoscopic ablation, 58 had paroxysmal @entity1 and 49 had persistent or long-standing @entity1 . The procedure was performed on the beating heart through three ports on the left chest wall. Three circular and two linear lesions were made on the left atrium. The left atrial appendage was excised by stapler. Echocardiography was performed preoperatively and at the 2-year follow-up. RESULTS: Most @entity0 (86.9%) @entity0 were in sinus rhythm (SR) postoperatively. Fourteen @entity0 (5 with paroxysmal @entity1 and 9 with persistent/long-standing @entity1 ) failed to maintain SR. Echocardiographic data indicated that the left atrial diameter decreased only in the @entity0 with postoperative SR but continued to increase in @entity0 with fail SR maintenance. Left atrial function was also improved after the procedure, especially in @entity0 with preoperative nonparoxysmal @entity1 or with postoperative SR maintenance. Furthermore, left atrial function in @entity0 who failed to restore SR was not worsened even with left @entity1 . CONCLUSIONS: Modified endoscopic procedure for @entity1 improved post-procedural left atrial function of @entity0 with SR maintenance. The left atrial function of @entity0 with failed SR maintenance was also not worsened after left @entity1 .

title: Study on Left Atrial Dimension and Function After Modified Endoscopic Procedure for XXXX at Two Years' Follow-Up.

answer: @entity1


abstract: Scleral fibroblasts are involved in scleral remodeling during axial elongation in @entity1 . Mechanical load is a potent stimulator of gene expression. This study seeks to identify changes in gene expression of scleral fibroblasts in response to mechanical load and speculate on possible mechanisms of scleral remodeling in the development of @entity1 . @entity0 scleral fibroblasts (HSFs) were mechanically stretched for 30 min and 24 hr. A gene microarray analysis was used to measure changes in gene expression. A total of 237 genes revealed differential and significant changes in expression (P<0.01) after 30 min of stretching. Of these, 28 unexpressed genes began to be expressed (turned on), while 31 expressed genes were no longer expressed (turned off). After 24 hr, 308 genes showed reproducible changes in expression (P<0.01), while 29 genes were turned on and 17 genes were turned off. After 30 min, 25 genes showed at least a threefold change in expression. These included genes for cell receptors, protein kinases, cell growth/differentiation factors, extracellular matrix (ECM) proteins, lipid metabolism, protein metabolism, transcription factors, binding proteins and water channels. After 24 hr, 21 genes showed at least a threefold change in expression. These included genes for cell receptors, protein kinases, cell growth/differentiation factors, lipid metabolism, ECM proteins, transcription factors, and @entity2 metabolism. RT-PCR and Southern blotting confirmed the changes in expression of selected genes. In this study we identified a large number of early and late mechanical response genes in HSFs. These changes in gene expression will provide potential candidate genes that might be involved in scleral remodeling during axial elongation in @entity1 .

title: Changes in gene expression in response to mechanical strain in XXXX scleral fibroblasts.

answer: @entity0


abstract: BACKGROUND: There is evidence that acute myocardial infraction (aMI) occurs more frequently in certain seasons and months of the year. Recently various infectious agents have been implicated in atherogenesis. In the present study we recorded the seasonal distribution of aMI and evaluated its relation to @entity1 ( @entity1 ). METHODS: The study included 1196 @entity0 with aMI hospitalized during the years 1988-1998 in the General Hospital of the island of Rhodes and 2976 @entity0 with AI during the years 1993-1998. Foreigners or visitors in the island were excluded to avoid their influence in the annual distribution. We corrected the absolute number of the aMI and AI cases by month and season in such a way that all months and seasons would have standard 30 and 90 days, respectively. RESULTS: During the entire period of the study, more @entity0 with aMI were hospitalized in winter [30.7%, 95% confidence limits (CL) 28.1 to 33.3%]. In spring the percentage of aMI cases hospitalized was 24.5% (CL 22.1-27%), in summer 23.2% (CL 20.1-25.6%) and in autumn 21.6% (CL 19.2 -24%). There were 42.35% more cases hospitalized in winter than in autumn. The monthly distribution showed that March was the month with the most aMI cases (10.83%, CL 9.06-12.6% ) and October with the fewest (6%, @entity3 .65-7.35%). The percentage of @entity0 with AI hospitalized in winter was 30.5% (CL 28.8-32.2%), in spring 25.2% (23.6-26.7), in summer 23.5% (CL 22-25%) and in autumn 20.8% (CL 19.4-22.3%). The correlation coefficient (r) between the distribution of aMI and AI was 0.73 (P<0.01). CONCLUSIONS: Our results indicate that (1) there is a seasonal distribution in aMI with the winter being the season of the highest incidence of aMI and autumn of the lowest and (2) there is a significant correlation of the distribution of aMI to AI cases, which is of interest in the understanding of the pathogenesis of @entity2 .

title: Seasonal distribution of acute myocardial infarction and its relation to XXXX in a mild climate.

answer: @entity1


abstract: OBJECTIVE: Safety and efficacy of therapeutic agents used for @entity7 -induced @entity3 are not established in pregnancy. METHODS: MEDLINE database was searched in November 2014 to identify all @entity0 who received therapy for HIT during pregnancy. RESULTS: A total of 12 @entity0 with the median age of 28 years (range 21-39) were diagnosed with HIT at the median gestational age of 20 weeks (range 5-34). Clinical probability (4T) score for HIT was high (50%) or intermediate (50%) and associated with @entity2 in 50%. @entity0 were initially managed with lepirudin (33%), @entity8 (25%), danaparoid (25%) or fondaparinux (17%) and ultimately bridged to @entity5 antagonist or maintained on lepirudin. All @entity0 had resolution of HIT. Complications included therapeutic abortion prior to valve replacement for valve @entity2 (8%), @entity6 (18%) and @entity4 (8%). Except for one instance of hypoplastic lung related to @entity6 , none of the other newborns had any complications during delivery. CONCLUSION: Confirmed cases of HIT in pregnant @entity0 appear to be rare. Within the limits of retrospective analysis, the use of @entity8 , danaparoid, fondaparinux and lepirudin may be effective in preventing the @entity2 complications of HIT in pregnancy. The effect of HIT or its therapy on @entity1 cannot be determined based on this study since many of the @entity1 are common in otherwise healthy pregnancies. Although this study did not identify any fetal teratogenicity except hypoplastic lung related to @entity6 , small number of cases treated with various therapies precludes any definite conclusion.

title: Management and Outcome of XXXX -Induced @entity3 in Pregnancy: A Systematic Review.

answer: @entity7


abstract: OBJECTIVE: Safety and efficacy of therapeutic agents used for @entity7 -induced @entity3 are not established in pregnancy. METHODS: MEDLINE database was searched in November 2014 to identify all @entity0 who received therapy for HIT during pregnancy. RESULTS: A total of 12 @entity0 with the median age of 28 years (range 21-39) were diagnosed with HIT at the median gestational age of 20 weeks (range 5-34). Clinical probability (4T) score for HIT was high (50%) or intermediate (50%) and associated with @entity2 in 50%. @entity0 were initially managed with lepirudin (33%), @entity8 (25%), danaparoid (25%) or fondaparinux (17%) and ultimately bridged to @entity5 antagonist or maintained on lepirudin. All @entity0 had resolution of HIT. Complications included therapeutic abortion prior to valve replacement for valve @entity2 (8%), @entity6 (18%) and @entity4 (8%). Except for one instance of hypoplastic lung related to @entity6 , none of the other newborns had any complications during delivery. CONCLUSION: Confirmed cases of HIT in pregnant @entity0 appear to be rare. Within the limits of retrospective analysis, the use of @entity8 , danaparoid, fondaparinux and lepirudin may be effective in preventing the @entity2 complications of HIT in pregnancy. The effect of HIT or its therapy on @entity1 cannot be determined based on this study since many of the @entity1 are common in otherwise healthy pregnancies. Although this study did not identify any fetal teratogenicity except hypoplastic lung related to @entity6 , small number of cases treated with various therapies precludes any definite conclusion.

title: Management and Outcome of @entity7 -Induced XXXX in Pregnancy: A Systematic Review.

answer: @entity3


abstract: Eph receptors and their cognate ligands ephrins are important players in axon guidance and neural patterning during development of the nervous system. Much of our knowledge about the signal transduction pathways triggered by Eph receptors has been related to the modulation of actin cytoskeleton, which is fundamental in mediating the cellular responses in growth cone navigation, cell adhesion, and cell migration. In contrast, little was known about whether long term activation of Eph receptor would regulate gene expression. Here we report a novel signaling pathway of @entity5 , which involves activation of the @entity1 kinase @entity7 and the transcriptional activator @entity4 . Transfection of COS7 cells with @entity5 , but not the kinase-dead mutant, induced @entity1 phosphorylation of @entity7 , @entity6 , and @entity4 . Treatment of cultured C2C12 myotubes with @entity9 also induced @entity1 phosphorylation of @entity4 , which was abolished by the @entity7 inhibitor @entity8 . Moreover, @entity7 was co-immunoprecipitated with @entity5 in muscle, and both proteins were concentrated at the neuromuscular junction (NMJ) of adult muscle. By using microarray analysis, we have identified @entity3 , the critical enzyme that hydrolyzed the neurotransmitter @entity2 at the NMJ, as a downstream target gene of the Jak/Stat pathway in muscle. More importantly, @entity9 increased the expression of @entity3 protein in C2C12 myotubes, which was abolished by @entity8 . In contrast, @entity9 reduced the expression of fibronectin mRNA in C2C12 myotubes independently of @entity7 . Finally, the expression level of @entity3 in limb muscle of @entity5 null @entity0 was significantly reduced compared with the wild-type control. Taken together, these results have identified Jak/Stat proteins as the novel downstream targets of @entity5 signaling. In addition, the present study provides the first demonstration of a potential function of Eph receptors and Jak/Stat proteins at the NMJ.

title: Identification of the Jak/Stat proteins as novel downstream targets of @entity5 signaling in muscle: implications in the regulation of XXXX expression.

answer: @entity3


abstract: Eph receptors and their cognate ligands ephrins are important players in axon guidance and neural patterning during development of the nervous system. Much of our knowledge about the signal transduction pathways triggered by Eph receptors has been related to the modulation of actin cytoskeleton, which is fundamental in mediating the cellular responses in growth cone navigation, cell adhesion, and cell migration. In contrast, little was known about whether long term activation of Eph receptor would regulate gene expression. Here we report a novel signaling pathway of @entity5 , which involves activation of the @entity1 kinase @entity7 and the transcriptional activator @entity4 . Transfection of COS7 cells with @entity5 , but not the kinase-dead mutant, induced @entity1 phosphorylation of @entity7 , @entity6 , and @entity4 . Treatment of cultured C2C12 myotubes with @entity9 also induced @entity1 phosphorylation of @entity4 , which was abolished by the @entity7 inhibitor @entity8 . Moreover, @entity7 was co-immunoprecipitated with @entity5 in muscle, and both proteins were concentrated at the neuromuscular junction (NMJ) of adult muscle. By using microarray analysis, we have identified @entity3 , the critical enzyme that hydrolyzed the neurotransmitter @entity2 at the NMJ, as a downstream target gene of the Jak/Stat pathway in muscle. More importantly, @entity9 increased the expression of @entity3 protein in C2C12 myotubes, which was abolished by @entity8 . In contrast, @entity9 reduced the expression of fibronectin mRNA in C2C12 myotubes independently of @entity7 . Finally, the expression level of @entity3 in limb muscle of @entity5 null @entity0 was significantly reduced compared with the wild-type control. Taken together, these results have identified Jak/Stat proteins as the novel downstream targets of @entity5 signaling. In addition, the present study provides the first demonstration of a potential function of Eph receptors and Jak/Stat proteins at the NMJ.

title: Identification of the Jak/Stat proteins as novel downstream targets of XXXX signaling in muscle: implications in the regulation of @entity3 expression.

answer: @entity5


abstract: FtsE and FtsX have homology to the ABC transporter superfamily of proteins and appear to be widely conserved among bacteria. Early work implicated FtsEX in cell division in @entity0 , but this was subsequently challenged, in part because the division defects in ftsEX mutants are often salt remedial. Strain RG60 has an ftsE::kan null mutation that is polar onto ftsX. RG60 is mildly filamentous when grown in standard Luria-Bertani medium (LB), which contains 1% @entity1 , but upon shift to LB with no @entity1 growth and division stop. We found that FtsN localizes to potential division sites, albeit poorly, in RG60 grown in LB with 1% @entity1 . We also found that in wild-type @entity0 both FtsE and FtsX localize to the division site. Localization of FtsX was studied in detail and appeared to require FtsZ, FtsA, and ZipA, but not the downstream division proteins FtsK, FtsQ, FtsL, and FtsI. Consistent with this, in media lacking salt, FtsA and ZipA localized independently of FtsEX, but the downstream proteins did not. Finally, in the absence of salt, cells depleted of FtsEX stopped dividing before any change in growth rate (mass increase) was apparent. We conclude that FtsEX participates directly in the process of cell division and is important for assembly or stability of the septal ring, especially in salt-free media.

title: A predicted ABC transporter, FtsEX, is needed for cell division in XXXX .

answer: @entity0


abstract: OBJECTIVE: To study the correlations of @entity3 gene polymorphism and serum @entity2 levels with @entity1 predictive index (API) in @entity0 . METHODS: One hundred and sixty-seven @entity0 with positive API, 187 @entity0 with negative API and 203 healthy @entity0 (control group) were enrolled. PCR and DNA sequencing were used to identify genotypes of the @entity4 locus in @entity3 gene. Serum @entity2 levels were measured using ELISA. RESULTS: There was no significant difference in the genotype frequencies of the @entity4 locus in @entity3 gene among the positive API, negative API and control groups. Serum @entity2 levels in the positive API group were significantly higher than in the negative API and control groups (P<0.01). In the positive API group, the @entity0 aged less than 2 years had significantly lower serum @entity2 levels than those aged over 2 years (P<0.01). CONCLUSIONS: There is no correlation between the @entity4 polymorphism in @entity3 gene and API results. API positivity is correlated with elevated serum @entity2 levels. An older age (>2 years) may be a risk factor for increased serum @entity2 levels in @entity0 with positive API.

title: [Correlations of @entity3 gene polymorphism and serum XXXX levels with @entity1 predictive index].

answer: @entity2


abstract: OBJECTIVE: To study the correlations of @entity3 gene polymorphism and serum @entity2 levels with @entity1 predictive index (API) in @entity0 . METHODS: One hundred and sixty-seven @entity0 with positive API, 187 @entity0 with negative API and 203 healthy @entity0 (control group) were enrolled. PCR and DNA sequencing were used to identify genotypes of the @entity4 locus in @entity3 gene. Serum @entity2 levels were measured using ELISA. RESULTS: There was no significant difference in the genotype frequencies of the @entity4 locus in @entity3 gene among the positive API, negative API and control groups. Serum @entity2 levels in the positive API group were significantly higher than in the negative API and control groups (P<0.01). In the positive API group, the @entity0 aged less than 2 years had significantly lower serum @entity2 levels than those aged over 2 years (P<0.01). CONCLUSIONS: There is no correlation between the @entity4 polymorphism in @entity3 gene and API results. API positivity is correlated with elevated serum @entity2 levels. An older age (>2 years) may be a risk factor for increased serum @entity2 levels in @entity0 with positive API.

title: [Correlations of XXXX gene polymorphism and serum @entity2 levels with @entity1 predictive index].

answer: @entity3


abstract: OBJECTIVE: To study the correlations of @entity3 gene polymorphism and serum @entity2 levels with @entity1 predictive index (API) in @entity0 . METHODS: One hundred and sixty-seven @entity0 with positive API, 187 @entity0 with negative API and 203 healthy @entity0 (control group) were enrolled. PCR and DNA sequencing were used to identify genotypes of the @entity4 locus in @entity3 gene. Serum @entity2 levels were measured using ELISA. RESULTS: There was no significant difference in the genotype frequencies of the @entity4 locus in @entity3 gene among the positive API, negative API and control groups. Serum @entity2 levels in the positive API group were significantly higher than in the negative API and control groups (P<0.01). In the positive API group, the @entity0 aged less than 2 years had significantly lower serum @entity2 levels than those aged over 2 years (P<0.01). CONCLUSIONS: There is no correlation between the @entity4 polymorphism in @entity3 gene and API results. API positivity is correlated with elevated serum @entity2 levels. An older age (>2 years) may be a risk factor for increased serum @entity2 levels in @entity0 with positive API.

title: [Correlations of @entity3 gene polymorphism and serum @entity2 levels with XXXX predictive index].

answer: @entity1


abstract: BACKGROUND: The effectiveness of once per week (OPW) delivery of a family-based childhood @entity1 programme was compared with twice per week (TPW) delivery in achieving health and behavioural outcomes at a population level and in improving programme attendance. Both programmes were delivered over 10-weeks, and the contact hours in the OPW and TPW programmes were 20 and 35-h, respectively. METHODS: A cluster-randomised controlled trial with stratification by local health district was conducted. Height, weight and global self esteem of @entity0 and parent-reported diet and physical activity were measured at programme commencement and completion and at 6-month follow-up. Attendance was defined as the proportion of total sessions attended. RESULTS: There were no differences between the OPW and TPW arms in changes from pre-programme baseline for body mass index (BMI) z-score and other health and behaviourial measures at programme completion and at follow-up, except for the increase in physical activity outside of the programme at programme completion (OPW, 3.5   h/week; TPW, 1.9   h/week; p   =   0.03). OPW and TPW @entity0 attended 71.2% and 69.2% of the total sessions, respectively. Attendance was the only contributing factor to a positive BMI z-score outcome (b   = -2.45, p   <   0.01) with no effects of @entity0 age and gender, language spoken at home or highest qualification of mother. CONCLUSIONS: A family-based childhood @entity1 programme can be delivered OPW with no compromise to health or behavioural outcomes compared with TPW. Higher attendance, as a proportion of available sessions, leads to better outcomes for @entity0 .

title: Effectiveness of a once per week delivery of a family-based childhood XXXX intervention: a cluster randomised controlled trial.

answer: @entity1


abstract: AIM: The use of @entity3 ( @entity3 ) in experimental surgery is an extended method to evaluate cardiac graft viability. To study endothelial injury after @entity0 -reperfusion, the technique described by Matsui et al. in 1988 for @entity3 was chosen. A modification, which consists of replacing the atrium-to-atrium @entity2 for the tip of a 30-Fr venous cannula, was developed with the purpose of using this technique in small @entity5 . Both techniques were compared. METHODS: Twenty-seven consecutive HHTs in 17- to 20-kg @entity5 using Matsui's original technique and the modified technique were performed. @entity0 time, @entity4 volume, mean gradient and @entity2 complications were measured to compare both techniques. RESULTS: Statistically significant decreases in @entity0 time, @entity4 volume and mean gradient with the modified technique were found. Furthermore, there were two cases of suture dehiscence with the original technique. CONCLUSIONS: The replacement of the atrium-to-atrium @entity2 for the venous cannula is a modification that statistically decreases the @entity0 time, @entity1 and avoids suture complications. This modification makes Matsui's technique easier, faster and safer in small @entity5 and it may be used in bigger animals and in any kind of non-permanent @entity2 .

title: Experimental XXXX : an easier technique.

answer: @entity3


abstract: OBJECTIVE: To investigate the clinical features and management of intractable deep-seated @entity4 . METHODS: Clinical data were analyzed retrospectively in 195 @entity0 with intractable deep-seated @entity4 treated in Affiliated Hospital of Qingdao College between June 2008 and June 2014. The analyses included common risk factors, @entity3 sites, treatments and therapeutic effects. SPSS 17.0 software was used to analyze the data. RESULTS: There were 162 males and 33 females, aged from 15 to 88 years old (mean 52    16 years). One hundred and eighty-seven cases (95.9%) were unilateral and 8 cases (4.1%) were bilateral. One hundred and twenty-six cases (64.6%) had the history of @entity2 or blood pressure higher than normal on admission. Eight @entity0 were cured by nasal packing and appropriate drugs, and 187 @entity0 were treated by endoscopy and electrocoagulation. The numbers of treatment needed to stop @entity3 were 1 time in 184 cases (98.4%), 2 times in 3 cases (1.6%). Thirteen cases did not have certain @entity3 point, while the other 174 had certain one or more @entity3 sites. The rewarded @entity3 sites were 222, which were found in the following different sites: posterior inferior nasal meatus (33.3%, 74 /222), olfactory cleft of nasal septum (26.6%, 59/222), the root of the middle turbinate (14.0%, 31/222), and so on. @entity2 and @entity1 were risk factors (OR value was 3.411, 7.142, both P < 0.05). CONCLUSIONS: Intractable deep-seated @entity4 are mainly found in males and are almost unilatera1. @entity2 and @entity1 are the common risk factor. The most effective and safe treatment for intractable deep-seated @entity4 is electrocoagulation under nasal endoscopy.

title: [Clinical analyses of @entity0 with intractable XXXX originated from deep-seated nasal cavity].

answer: @entity4