abstract: BACKGROUND: Secondary lesion (SL) is an early @entity3 following @entity6 ( @entity6 ). @entity4 (NO) could be involved in its pathogenesis. NO is a gaseous metabolite produced by 2 constitutive isoforms of NO synthase ( @entity7 ), constantly active, and by 1 inducible isoform (iNOS), synthesized during @entity0 and able to produce large amount of NO. High concentrated NO is toxic for cells; therefore, NO concentration is strictly and finely regulated. We suppose that major inhibitory effect on the iNOS expression is represented by the same physiological concentration of NO, synthesized by @entity7 . The aim of this study is to assess the role of the 2 @entity7 in pathogenesis of SL after @entity6 in @entity1 . METHODS: A dorsal @entity6 has been performed on @entity1 (n=5) by a vascular clip (50 g/mm(2) for 15"). Fifteen minutes after @entity2 , activity of nNOS and eNOS has been measured (U/mg) in the cervical, dorsal and lumbar segments of spinal cord. Uninjured @entity1 (n=5) served as control group. m-RNA for iNOS in untreated @entity1 (n=2) has been also investigated by Northern blotting. RESULTS: In injured @entity1 nNOS activity has shown a reduction in dorsal and lumbar segments, compared to the control group. eNOS activity, highly variable in the control group, has not been detectable in injured spinal cord. @entity5 mRNA has not been found in spinal cord of uninjured @entity1 . CONCLUSIONS: These results would be in line with our hypothesis and provide the bases for other investigations. New therapeutic strategies for SL prevention, based on the modulation of @entity7 , will be evaluated.

title: The role of constitutive XXXX synthase in pathogenesis of secondary lesion after @entity6 . Preliminary results.

answer: @entity4


abstract: BACKGROUND: Different lifestyle choices are commonly regarded as a reflection of socioeconomic status, and the latter is inversely correlated with the risk of developing @entity1 . However, the details of this association are still unclear in terms of the degree to which lifestyle factors are having impact. To explain the correlation between socioeconomic status and @entity1 , we therefore examined the roles played by different lifestyle factors. METHODS: A prospective cohort study of diet and @entity1 was initiated in Japan during 1988. Data were collected by means of a self-administered questionnaire. A follow-up survey was conducted annually, and the cause of @entity3 was recorded from the @entity3 certificate. The total of 127,477 study @entity0 resided in 45 areas of Japan, and we retrieved data for 18,746 @entity0 and 26,184 @entity0 for the present analysis. After 328,030 @entity0 -years of follow-up, 379 deaths from @entity1 were detected: 261 in @entity0 and 118 in @entity0 . RESULTS: For @entity0 , the age-adjusted relative risk was lowest in the highly educated group (relative risk = 0.72, 95% CI: 0.50-1.04). Relative risk after adjustment for age and dietary choices (including pickles, vegetables, fruit, green tea, and preference for salty foods) was the same as the age-adjusted relative risk (relative risk = 0.72, 95% CI: 0.50-1.04). CONCLUSION: The expected inverse correlation between education level and @entity3 from @entity1 was observed in @entity0 . However, this association could not be explained by differences in dietary habits, smoking, or @entity2 consumption associated with socioeconomic status.

title: Prospective study of educational background and XXXX in Japan.

answer: @entity1


abstract: Neck lymph node status is the most important factor for prognosis in @entity6 . Sentinel node detection reliably predicts the lymph node status in @entity7 and @entity0 @entity1 . This study evaluates the predictive value of sentinel node detection in 50 @entity1 suffering from @entity5 with a N0 neck as assessed by ultrasound imaging. Following @entity9 nanocolloid injection in the perimeter of the @entity3 intraoperative sentinel node detection was performed during lymph node dissection. Postoperatively the histological results of the sentinel nodes were compared with the excised neck dissection specimen. Identification of sentinel nodes was successful in all 50 @entity1 with a sensitivity of 89%. In eight cases the sentinel node showed @entity4 ( @entity10 ). In 41 @entity1 the sentinel node was @entity3 negative reflecting the correct neck lymph node status (pN0). We observed one false-negative result. In this case the sentinel node was free of @entity3 , whereas a neighbouring lymph node contained a lymph node @entity2 ( @entity10 ). Although we have shown, that skipping of nodal basins can occur, this technique still reliably identifies the sentinel nodes of @entity1 with @entity8 of the pharynx and larynx. Future studies must show, if sentinel node detection is suitable to limit the extent of lymph node dissection in clinically N0 necks of @entity1 suffering from pharyngeal and @entity8 .

title: Sentinel node detection in N0 XXXX of the pharynx and larynx.

answer: @entity3


abstract: A sequencing batch reactor (SBR) was started up and operated with alternating anaerobic/oxic (An/O) to perform enhanced biological @entity3 removal (EBPR) under the condition of 13-16 degrees C. The results showed that under the condition of low temperature, the EBPR system was successfully started up in a short time (<6 d). The reactor achieved a high and stable @entity3 removal performance with an influent @entity5 concentration of 20 mg x L(-1) and the dissolved @entity0 (DO) concentration of 2 mg x L(-1). The effluent @entity5 concentration was lower than 0.5 mg x L(-1). It was found that decreasing DO had an influence on the steady operation of EBPR system. As DO concentration of aerobic phase decreased from 2 mg x L(-1) to 1 mg x L(-1), the system could still perform EBPR and the @entity3 removal efficiency was greater than 97.4%. However, the amount of @entity5 released during anaerobic phase was observed to decrease slightly compared with that of 2 mg x L(-1) @entity1 . Moreover, the @entity3 removal performance of the system deteriorated immediately and the effluent @entity5 concentration couldn't meet the national integrated wastewater discharge standard when DO concentration was further lowered to 0.5 mg x L(-1). The experiments of increasing DO to recover @entity3 removal performance of the EBPR suggested the process failure resulted from low DO was not reversible in the short-term. It was also found that the batch tests of anoxic @entity3 uptake using @entity4 and @entity2 as electron acceptors had an impact on the stable operation of EBPR system, whereas the resulting negative influence could be recovered within 6 cycles. In addition, the mixed liquid suspended solids (MLSS) of the EBPR system remained stable and the sludge volume index (SVI) decreased to a certain extend in a long run, implying long-term low temperature and low @entity1 favored the sludge sedimentation.

title: [Startup, stable operation and process failure of EBPR system under the low temperature and low dissolved XXXX condition].

answer: @entity0


abstract: This study was conducted in order to investigate the advantages and limitations of four analgesic modalities: a) epidural @entity4 ; b) intravenous @entity4 ; c) @entity0 controlled intravenous @entity4 ( @entity0 -controlled analgesia); and d) non-steroidal anti-inflammatory drugs. Eighty @entity0 undergoing major abdominal surgical procedures were prospectively and randomly treated with one of the above-mentioned analgesic methods. Evaluation of @entity1 perception was done using the visual analogue @entity1 score and the simple descriptive scale 4 hours after the procedure, in the early morning on postoperative day 1 and in the afternoon on postoperative days 1, 2 and 3. The need for @entity3 , if any, were also evaluated for each @entity0 . @entity0 -controlled intravenous @entity4 yielded the best analgesic effect over the entire period. Epidural @entity4 was more effective in the very early postoperative period compared to modalities (b) and (d). Non-steroidal anti-inflammatory drugs, on the other hand, were more effective on the later postoperative days. None of the @entity0 in group C needed supplementary analgesia, as against 20% in group A, 55% in group B and 40% in group D. @entity0 with @entity5 scores > 70 or @entity2 scores > 70 required supplementation of analgesia more often. @entity4 proved to be the drug of choice. Drug titration may be modulated in relation to the psychological characteristics of the @entity0 . The best drug titration modality, in fact, is @entity0 -controlled analgesia.

title: A prospective randomized clinical trial on XXXX control after major abdominal surgery.

answer: @entity1


abstract: NSAIDs are reported to increase the risk of @entity1 in @entity5 users. The mechanism underlying this risk is inhibition of @entity4 , however a pharmacokinetic mechanism resulting in an increased International Normalised Ratio (INR) was proposed in some case reports in @entity3 treated @entity0 . In this retrospective cohort study the influence of @entity7 , @entity6 and @entity8 on the INR of outpatients stabilised on @entity10 therapy was investigated. We also determined the role of @entity9 ( @entity9 ) polymorphism on @entity5 dosage and INR in NSAID users. The study was carried out at the Groningen Outpatient @entity2 Service. A retrospective cohort study among @entity0 who received both @entity10 and one of the NSAIDs under study was performed. @entity0 whose INR rose above the upper level of the therapeutic range (INR above 3.5 or 4.0) after an NSAID under study was added to the @entity10 therapy, were compared with @entity0 who did not show such an elevation. A two-sample t-test (average @entity10 dosage, age), and chi-square tests (sex, therapeutic range, type of NSAID) were used to test for differences. Genotyping was carried out by analysing blood samples for the relevant @entity9 alleles. The study population consisted of 112 @entity0 on stable @entity10 therapy, of which 52 (46%) showed an elevation of the INR above the desired therapeutic level (INR 3.5 and 4.0 respectively) after the start of an NSAID under study. In 12 @entity0 , the INR increased above 6. The INR of the other 60 @entity0 (54%) remained constant after the start of one of the NSAIDs under study. There were no statistically significant differences between @entity0 with increased INR and @entity0 without increased INR with regard to age, sex, therapeutic range and average @entity10 dosage. Eighty @entity0 , of whom 36 showed an increased INR as a result of a potential @entity10 -NSAID drug interaction, were included in the genotyping study. No association between @entity9 genotype and an increased INR as a result of the drug-drug interaction was found. In nearly half of a cohort of elderly @entity0 , the INR increased beyond the therapeutic range (INR 3.5 or 4.0) as a result of a potential pharmacokinetic drug-drug interaction between @entity10 and @entity7 , @entity6 and @entity8 . The average increase in INR was between 1 and 4. Polymorphism of @entity9 does not seem to be a relevant risk factor for the NSAID- @entity10 interaction.

title: Potential interaction between @entity10 and @entity7 , @entity6 and @entity8 and role of XXXX genotype.

answer: @entity9


abstract: NSAIDs are reported to increase the risk of @entity1 in @entity5 users. The mechanism underlying this risk is inhibition of @entity4 , however a pharmacokinetic mechanism resulting in an increased International Normalised Ratio (INR) was proposed in some case reports in @entity3 treated @entity0 . In this retrospective cohort study the influence of @entity7 , @entity6 and @entity8 on the INR of outpatients stabilised on @entity10 therapy was investigated. We also determined the role of @entity9 ( @entity9 ) polymorphism on @entity5 dosage and INR in NSAID users. The study was carried out at the Groningen Outpatient @entity2 Service. A retrospective cohort study among @entity0 who received both @entity10 and one of the NSAIDs under study was performed. @entity0 whose INR rose above the upper level of the therapeutic range (INR above 3.5 or 4.0) after an NSAID under study was added to the @entity10 therapy, were compared with @entity0 who did not show such an elevation. A two-sample t-test (average @entity10 dosage, age), and chi-square tests (sex, therapeutic range, type of NSAID) were used to test for differences. Genotyping was carried out by analysing blood samples for the relevant @entity9 alleles. The study population consisted of 112 @entity0 on stable @entity10 therapy, of which 52 (46%) showed an elevation of the INR above the desired therapeutic level (INR 3.5 and 4.0 respectively) after the start of an NSAID under study. In 12 @entity0 , the INR increased above 6. The INR of the other 60 @entity0 (54%) remained constant after the start of one of the NSAIDs under study. There were no statistically significant differences between @entity0 with increased INR and @entity0 without increased INR with regard to age, sex, therapeutic range and average @entity10 dosage. Eighty @entity0 , of whom 36 showed an increased INR as a result of a potential @entity10 -NSAID drug interaction, were included in the genotyping study. No association between @entity9 genotype and an increased INR as a result of the drug-drug interaction was found. In nearly half of a cohort of elderly @entity0 , the INR increased beyond the therapeutic range (INR 3.5 or 4.0) as a result of a potential pharmacokinetic drug-drug interaction between @entity10 and @entity7 , @entity6 and @entity8 . The average increase in INR was between 1 and 4. Polymorphism of @entity9 does not seem to be a relevant risk factor for the NSAID- @entity10 interaction.

title: Potential interaction between @entity10 and @entity7 , XXXX and @entity8 and role of @entity9 genotype.

answer: @entity6


abstract: NSAIDs are reported to increase the risk of @entity1 in @entity5 users. The mechanism underlying this risk is inhibition of @entity4 , however a pharmacokinetic mechanism resulting in an increased International Normalised Ratio (INR) was proposed in some case reports in @entity3 treated @entity0 . In this retrospective cohort study the influence of @entity7 , @entity6 and @entity8 on the INR of outpatients stabilised on @entity10 therapy was investigated. We also determined the role of @entity9 ( @entity9 ) polymorphism on @entity5 dosage and INR in NSAID users. The study was carried out at the Groningen Outpatient @entity2 Service. A retrospective cohort study among @entity0 who received both @entity10 and one of the NSAIDs under study was performed. @entity0 whose INR rose above the upper level of the therapeutic range (INR above 3.5 or 4.0) after an NSAID under study was added to the @entity10 therapy, were compared with @entity0 who did not show such an elevation. A two-sample t-test (average @entity10 dosage, age), and chi-square tests (sex, therapeutic range, type of NSAID) were used to test for differences. Genotyping was carried out by analysing blood samples for the relevant @entity9 alleles. The study population consisted of 112 @entity0 on stable @entity10 therapy, of which 52 (46%) showed an elevation of the INR above the desired therapeutic level (INR 3.5 and 4.0 respectively) after the start of an NSAID under study. In 12 @entity0 , the INR increased above 6. The INR of the other 60 @entity0 (54%) remained constant after the start of one of the NSAIDs under study. There were no statistically significant differences between @entity0 with increased INR and @entity0 without increased INR with regard to age, sex, therapeutic range and average @entity10 dosage. Eighty @entity0 , of whom 36 showed an increased INR as a result of a potential @entity10 -NSAID drug interaction, were included in the genotyping study. No association between @entity9 genotype and an increased INR as a result of the drug-drug interaction was found. In nearly half of a cohort of elderly @entity0 , the INR increased beyond the therapeutic range (INR 3.5 or 4.0) as a result of a potential pharmacokinetic drug-drug interaction between @entity10 and @entity7 , @entity6 and @entity8 . The average increase in INR was between 1 and 4. Polymorphism of @entity9 does not seem to be a relevant risk factor for the NSAID- @entity10 interaction.

title: Potential interaction between @entity10 and XXXX , @entity6 and @entity8 and role of @entity9 genotype.

answer: @entity7


abstract: NSAIDs are reported to increase the risk of @entity1 in @entity5 users. The mechanism underlying this risk is inhibition of @entity4 , however a pharmacokinetic mechanism resulting in an increased International Normalised Ratio (INR) was proposed in some case reports in @entity3 treated @entity0 . In this retrospective cohort study the influence of @entity7 , @entity6 and @entity8 on the INR of outpatients stabilised on @entity10 therapy was investigated. We also determined the role of @entity9 ( @entity9 ) polymorphism on @entity5 dosage and INR in NSAID users. The study was carried out at the Groningen Outpatient @entity2 Service. A retrospective cohort study among @entity0 who received both @entity10 and one of the NSAIDs under study was performed. @entity0 whose INR rose above the upper level of the therapeutic range (INR above 3.5 or 4.0) after an NSAID under study was added to the @entity10 therapy, were compared with @entity0 who did not show such an elevation. A two-sample t-test (average @entity10 dosage, age), and chi-square tests (sex, therapeutic range, type of NSAID) were used to test for differences. Genotyping was carried out by analysing blood samples for the relevant @entity9 alleles. The study population consisted of 112 @entity0 on stable @entity10 therapy, of which 52 (46%) showed an elevation of the INR above the desired therapeutic level (INR 3.5 and 4.0 respectively) after the start of an NSAID under study. In 12 @entity0 , the INR increased above 6. The INR of the other 60 @entity0 (54%) remained constant after the start of one of the NSAIDs under study. There were no statistically significant differences between @entity0 with increased INR and @entity0 without increased INR with regard to age, sex, therapeutic range and average @entity10 dosage. Eighty @entity0 , of whom 36 showed an increased INR as a result of a potential @entity10 -NSAID drug interaction, were included in the genotyping study. No association between @entity9 genotype and an increased INR as a result of the drug-drug interaction was found. In nearly half of a cohort of elderly @entity0 , the INR increased beyond the therapeutic range (INR 3.5 or 4.0) as a result of a potential pharmacokinetic drug-drug interaction between @entity10 and @entity7 , @entity6 and @entity8 . The average increase in INR was between 1 and 4. Polymorphism of @entity9 does not seem to be a relevant risk factor for the NSAID- @entity10 interaction.

title: Potential interaction between XXXX and @entity7 , @entity6 and @entity8 and role of @entity9 genotype.

answer: @entity10


abstract: NSAIDs are reported to increase the risk of @entity1 in @entity5 users. The mechanism underlying this risk is inhibition of @entity4 , however a pharmacokinetic mechanism resulting in an increased International Normalised Ratio (INR) was proposed in some case reports in @entity3 treated @entity0 . In this retrospective cohort study the influence of @entity7 , @entity6 and @entity8 on the INR of outpatients stabilised on @entity10 therapy was investigated. We also determined the role of @entity9 ( @entity9 ) polymorphism on @entity5 dosage and INR in NSAID users. The study was carried out at the Groningen Outpatient @entity2 Service. A retrospective cohort study among @entity0 who received both @entity10 and one of the NSAIDs under study was performed. @entity0 whose INR rose above the upper level of the therapeutic range (INR above 3.5 or 4.0) after an NSAID under study was added to the @entity10 therapy, were compared with @entity0 who did not show such an elevation. A two-sample t-test (average @entity10 dosage, age), and chi-square tests (sex, therapeutic range, type of NSAID) were used to test for differences. Genotyping was carried out by analysing blood samples for the relevant @entity9 alleles. The study population consisted of 112 @entity0 on stable @entity10 therapy, of which 52 (46%) showed an elevation of the INR above the desired therapeutic level (INR 3.5 and 4.0 respectively) after the start of an NSAID under study. In 12 @entity0 , the INR increased above 6. The INR of the other 60 @entity0 (54%) remained constant after the start of one of the NSAIDs under study. There were no statistically significant differences between @entity0 with increased INR and @entity0 without increased INR with regard to age, sex, therapeutic range and average @entity10 dosage. Eighty @entity0 , of whom 36 showed an increased INR as a result of a potential @entity10 -NSAID drug interaction, were included in the genotyping study. No association between @entity9 genotype and an increased INR as a result of the drug-drug interaction was found. In nearly half of a cohort of elderly @entity0 , the INR increased beyond the therapeutic range (INR 3.5 or 4.0) as a result of a potential pharmacokinetic drug-drug interaction between @entity10 and @entity7 , @entity6 and @entity8 . The average increase in INR was between 1 and 4. Polymorphism of @entity9 does not seem to be a relevant risk factor for the NSAID- @entity10 interaction.

title: Potential interaction between @entity10 and @entity7 , @entity6 and XXXX and role of @entity9 genotype.

answer: @entity8


abstract: AIMS: To assess the wound size reduction and time course for healing and to establish equations to predict the time course of wound healing in @entity5 , and ischemic @entity7 . METHODS: This prospective study evaluates wound healing over at least a 10-week period in 31 Type 1 or Type 2 @entity1 @entity0 with @entity6 . Thirteen consecutive @entity1 @entity0 with @entity6 , 10 consecutive @entity1 @entity0 with neuroischemic ulceration, and 8 @entity1 @entity0 with @entity4 were selected for the study. All @entity0 received identical @entity3 wound care including use of proper footwear, non-weight-bearing limb support, use of appropriate antibiotics, debridement, tight control of serum @entity2 levels, and careful monitoring of the @entity3 . @entity3 was assessed by planimetric measurement of the wound area every second week until wound healing. The time course of wound healing was calculated by the daily wound radius reduction. RESULTS: The wound area (mean+/-S.E.) in the @entity0 with @entity6 was 61.2+/-17.1 at the beginning and 3.2+/-1.5 mm(2) after 70 days (P=.005). The wound radius decreased by 0.045 mm (95% confidence interval [CI] 0.039-0.055) per day, with most of the wound healing being achieved between the first and seventh week of @entity3 care. The average healing time was 77.7 (95% CI 62-93) days. In the neuroischemic group, the initial average wound area was 26.6+/-7.0 mm(2), and 6.25+/-1.7 mm(2) after 10 weeks (P=.007). The wound radius reduction was 0.019 mm/day (95% CI 0.017-0.023) with an average healing time of 123.4 (95% CI 101-145) days. The @entity1 @entity0 with @entity4 had an average wound size of 32.6+/-13.1 at the beginning and 23.9+/-10.7 mm(2) after 70 days of @entity3 care (P=.06). The daily wound radius reduction was 0.0065 mm (95% CI 0.0039-0.0091). Average @entity3 duration was 133 (95% CI 116-149) days, but three of eight @entity0 achieved no wound healing. CONCLUSIONS: Providing standard care, the time course of wound healing in @entity7 is predominantly determined by etiologic factors, and less by wound size. Taking wound etiology and wound radius into account, the expected healing time can reliably be estimated in @entity3 .

title: Determinants and estimation of healing times in XXXX .

answer: @entity7


abstract: AIM: The surgical results for @entity4 ( @entity4 ) with and without duraplasty in @entity2 ( @entity2 ) were compared retrospectively. MATERIAL AND METHODS: Thirty-nine cases of @entity2 with and without @entity1 ( @entity1 ) were included. There were 18 @entity0 in the nonduraplasty and 21 in the duraplasty group. @entity1 , @entity3 ( @entity3 ), preoperative symptom duration, and postoperative @entity1 size were compared. RESULTS: No significant difference was found between improvement in the duraplasty group (81%) and the non-duraplasty group (61.1%). In cases whose symptom duration was 0-36 months, improvement in the duraplasty group (93%) was significantly better than in the nonduraplasty group (50%) (p < 0.01). The rate of syrinx regression was 92.3% in the duraplasty group and 12.5% in the non-duraplasty group (p < 0.05). In cases with @entity1 , the improvement was 21.4% in the non-duraplasty group compared to 78.6% in the duraplasty group (p=0.056). In cases with @entity3 greater than 10 mm, the improvement was 66.7% in the non-duraplasty group, whereas all six cases (100%) in the duraplasty group had improved. CONCLUSION: In @entity1 associated cases, cases with @entity3 greater than 10 mm, and whose symptom duration is less than 36 months, duraplasty is a more reliable choice despite a slightly higher rate of complications.

title: Comparison of the Surgical Results for Foramen Magnum Decompression with and without Duraplasty in XXXX .

answer: @entity2


abstract: BACKGROUND: Transoral endoluminal gastroplasty (EG) by the Bard Endocinch device is available for the treatment of @entity1 ( @entity1 ). This study assessed the early (<or=12 months) outcomes in @entity0 undergoing EG performed by one gastroenterologist compared with another set of @entity0 referred by the same gastroenterologist for @entity6 ( @entity6 ) at a foregut surgery center. METHODS: From June 2000 to July 2002, 87 consecutive @entity0 cared for by a single gastroenterologist were diagnosed with refractory @entity1 and underwent either EG (n = 47) or referral for @entity6 (n = 40). Preoperative evaluation included symptom assessment, pH studies, and motility studies. Outcomes were assessed by symptomatic improvement and dependence on anti-acid medications. Data analyzed by chi-square or Mann-Whitney tests are reported as mean +/- SEM. RESULTS: Preoperative symptom duration, @entity8 ( @entity8 ) score, % time pH < 4, and @entity7 were statistically similar in both treatment groups. The follow-up times for EG and @entity6 groups were 7.3 +/- 0.9 and 8 +/- 0.4 months, respectively. Of EG @entity0 , 94% were available for follow-up, and all @entity6 @entity0 had follow-up data. Overall, 66% of @entity0 were satisfied with EG as compared to 93% after @entity6 (p = 0.1). Postoperative PPI/motility agent use was 32% for EG and 13% for @entity6 (p = 0.03). Identifiable causes of EG failure were premature procedure termination due to @entity4 or @entity5 (three @entity0 ), intractable @entity3 (two @entity0 ), and delayed @entity2 (five @entity0 ). Three EG @entity0 subsequently had @entity6 within 6 months of the procedure. CONCLUSIONS: @entity6 offers greater reduction in medication use than EG, as well as more durable @entity0 satisfaction. Benefits of EG may include short-term symptomatic improvement while considering definitive surgical management.

title: Comparative results of endoluminal gastroplasty and @entity6 for the treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: Transoral endoluminal gastroplasty (EG) by the Bard Endocinch device is available for the treatment of @entity1 ( @entity1 ). This study assessed the early (<or=12 months) outcomes in @entity0 undergoing EG performed by one gastroenterologist compared with another set of @entity0 referred by the same gastroenterologist for @entity6 ( @entity6 ) at a foregut surgery center. METHODS: From June 2000 to July 2002, 87 consecutive @entity0 cared for by a single gastroenterologist were diagnosed with refractory @entity1 and underwent either EG (n = 47) or referral for @entity6 (n = 40). Preoperative evaluation included symptom assessment, pH studies, and motility studies. Outcomes were assessed by symptomatic improvement and dependence on anti-acid medications. Data analyzed by chi-square or Mann-Whitney tests are reported as mean +/- SEM. RESULTS: Preoperative symptom duration, @entity8 ( @entity8 ) score, % time pH < 4, and @entity7 were statistically similar in both treatment groups. The follow-up times for EG and @entity6 groups were 7.3 +/- 0.9 and 8 +/- 0.4 months, respectively. Of EG @entity0 , 94% were available for follow-up, and all @entity6 @entity0 had follow-up data. Overall, 66% of @entity0 were satisfied with EG as compared to 93% after @entity6 (p = 0.1). Postoperative PPI/motility agent use was 32% for EG and 13% for @entity6 (p = 0.03). Identifiable causes of EG failure were premature procedure termination due to @entity4 or @entity5 (three @entity0 ), intractable @entity3 (two @entity0 ), and delayed @entity2 (five @entity0 ). Three EG @entity0 subsequently had @entity6 within 6 months of the procedure. CONCLUSIONS: @entity6 offers greater reduction in medication use than EG, as well as more durable @entity0 satisfaction. Benefits of EG may include short-term symptomatic improvement while considering definitive surgical management.

title: Comparative results of endoluminal gastroplasty and XXXX for the treatment of @entity1 .

answer: @entity6


abstract: BACKGROUND: The aim of this study was to evaluate prospectively whether laparoscopic (LA) and @entity4 ( @entity4 ) are equally safe and feasible in the treatment of @entity3 . METHODS: A total of 517 @entity0 with @entity2 were randomly assigned to undergo LA or @entity4 appendectomy, based on the schedule of the attending surgeon on call. @entity0 age, sex, postoperative diagnosis, operating time, level of training of surgical resident, length of postoperative hospitalization, and minor and major @entity1 were recorded. Chi-square analysis and the Student t-test were used for statistical analysis. RESULTS: In all, 376 @entity4 and 141 LA were performed. The two groups were comparable in terms of @entity0 demographics and the incidence of @entity3 . The operative time was also similar (47.3 +/- 19.7 vs 49.9 +/- 12.9 min). The overall incidence of minor or major complications was 11.2% in the @entity4 group and 9.9% in the LA group. CONCLUSION: Pediatric @entity0 with @entity3 can safely be offered laparoscopic appendectomy without incurring a greater risk for complications. Nevertheless, a higher (but not significantly higher) abscess rate was found in @entity0 with @entity3 who underwent laparoscopy.

title: Open and laparoscopic appendectomy are equally safe and acceptable in XXXX .

answer: @entity0


abstract: UNASSIGNED: Heparins play an important role in cell growth, differentiation, migration and invasion. However, the molecular mechanisms of heparin mediated cellular behaviors are not well defined. To determine the effect of heparin on gene expression, we performed a cDNA microarray in a @entity2 cell line and found that heparin regulates transcription of genes involved in @entity3 metabolism. In this study, we showed a new role of heparin in the regulation of thioredoxin interacting protein, which is a major regulator of @entity3 metabolism, in @entity2 cell lines. We determined the importance of a unique @entity4 response element located on its promoter for the @entity5 -induced activation of thioredoxin-interacting protein and the modulatory role of heparin on nuclear accumulation of @entity4 response element associated proteins. We showed the importance of heparin mediated histone modifications and down-regulation of Enhancer of zeste 2 polycomb repressive complex 2 expression for heparin mediated overexpression of thioredoxin-interacting protein. When we tested biological significance of these data; we observed that cells overexpressing thioredoxin-interacting protein are less adhesive and proliferative, however they have a higher migration and invasion ability. Interestingly, heparin treatment increased thioredoxin-interacting protein expression in liver of @entity0 @entity1 . In conclusion, our results show that heparin activates thioredoxin-interacting protein expression in liver and @entity2 cells and provide the first evidences of regulatory roles of heparin on @entity4 response element associated factors. This study will contribute future understanding of the effect of heparin on @entity3 metabolism and @entity3 independent overexpression of thioredoxin-interacting protein during hepatocarcinogenesis.

title: Heparin treatment increases thioredoxin interacting protein expression in XXXX cells.

answer: @entity2


abstract: No relevant deficiency of @entity5 or genetic polymorphisms could thus far consistently be associated with @entity4 . We hypothesized that the substrates of the @entity5 protein, including FVII or FX (rather than the protein itself) could induce a @entity1 state. We created a novel TF-based clotting assay that evaluated the anticoagulant response to exogenously added recombinant @entity5 . The response to @entity5 was expressed as the ratio of the clotting time with and with-out @entity5 . By using 118 healthy controls, we established a reference range between 1.31 and 1.93 (mean value +/-2 standard deviations (SD), 1.62 +/-0.31). We then evaluated samples from 120 @entity0 with a history of @entity4 but no evidence of hereditary and acquired @entity1 . The range Coagulation Laboratory, Division of Haematology, University Hospital of Zurich, Zurich, Switzerland of the @entity0 ' ratios was significantly (P < 0.001) lower, falling between 1.2 and 1.78 (mean value +/-2 SD, 1.49 +/-0.29). Of the 120 @entity0 , 39 (32.5%) had a @entity5 sensitivity ratio below the 10th percentile of the controls, compared with 11 (9.3%) of the healthy controls. The crude odds ratio for @entity1 for subjects with a @entity5 sensitivity ratio below the 10th percentile was 13 (95% CI; range, 3.1 to 54.9) compared with those with a ratio above 1.8 (90th percentile). @entity0 with idiopathic @entity3 did not have a decreased @entity5 sensitivity ratio more often than @entity0 with @entity2 with a circumstantial risk factor. Based on these results, a reduced response to @entity5 may lead to an increased risk of @entity1 .

title: Decreased anticoagulant response to tissue factor pathway inhibitor in @entity0 with XXXX and otherwise no evidence of hereditary or acquired @entity1 .

answer: @entity4


abstract: No relevant deficiency of @entity5 or genetic polymorphisms could thus far consistently be associated with @entity4 . We hypothesized that the substrates of the @entity5 protein, including FVII or FX (rather than the protein itself) could induce a @entity1 state. We created a novel TF-based clotting assay that evaluated the anticoagulant response to exogenously added recombinant @entity5 . The response to @entity5 was expressed as the ratio of the clotting time with and with-out @entity5 . By using 118 healthy controls, we established a reference range between 1.31 and 1.93 (mean value +/-2 standard deviations (SD), 1.62 +/-0.31). We then evaluated samples from 120 @entity0 with a history of @entity4 but no evidence of hereditary and acquired @entity1 . The range Coagulation Laboratory, Division of Haematology, University Hospital of Zurich, Zurich, Switzerland of the @entity0 ' ratios was significantly (P < 0.001) lower, falling between 1.2 and 1.78 (mean value +/-2 SD, 1.49 +/-0.29). Of the 120 @entity0 , 39 (32.5%) had a @entity5 sensitivity ratio below the 10th percentile of the controls, compared with 11 (9.3%) of the healthy controls. The crude odds ratio for @entity1 for subjects with a @entity5 sensitivity ratio below the 10th percentile was 13 (95% CI; range, 3.1 to 54.9) compared with those with a ratio above 1.8 (90th percentile). @entity0 with idiopathic @entity3 did not have a decreased @entity5 sensitivity ratio more often than @entity0 with @entity2 with a circumstantial risk factor. Based on these results, a reduced response to @entity5 may lead to an increased risk of @entity1 .

title: Decreased anticoagulant response to tissue factor pathway inhibitor in @entity0 with @entity4 and otherwise no evidence of hereditary or acquired XXXX .

answer: @entity1


abstract: No relevant deficiency of @entity5 or genetic polymorphisms could thus far consistently be associated with @entity4 . We hypothesized that the substrates of the @entity5 protein, including FVII or FX (rather than the protein itself) could induce a @entity1 state. We created a novel TF-based clotting assay that evaluated the anticoagulant response to exogenously added recombinant @entity5 . The response to @entity5 was expressed as the ratio of the clotting time with and with-out @entity5 . By using 118 healthy controls, we established a reference range between 1.31 and 1.93 (mean value +/-2 standard deviations (SD), 1.62 +/-0.31). We then evaluated samples from 120 @entity0 with a history of @entity4 but no evidence of hereditary and acquired @entity1 . The range Coagulation Laboratory, Division of Haematology, University Hospital of Zurich, Zurich, Switzerland of the @entity0 ' ratios was significantly (P < 0.001) lower, falling between 1.2 and 1.78 (mean value +/-2 SD, 1.49 +/-0.29). Of the 120 @entity0 , 39 (32.5%) had a @entity5 sensitivity ratio below the 10th percentile of the controls, compared with 11 (9.3%) of the healthy controls. The crude odds ratio for @entity1 for subjects with a @entity5 sensitivity ratio below the 10th percentile was 13 (95% CI; range, 3.1 to 54.9) compared with those with a ratio above 1.8 (90th percentile). @entity0 with idiopathic @entity3 did not have a decreased @entity5 sensitivity ratio more often than @entity0 with @entity2 with a circumstantial risk factor. Based on these results, a reduced response to @entity5 may lead to an increased risk of @entity1 .

title: Decreased anticoagulant response to tissue factor pathway inhibitor in XXXX with @entity4 and otherwise no evidence of hereditary or acquired @entity1 .

answer: @entity0


abstract: Allogeneic @entity2 ( @entity3 ) was prepared by culturing fibroblasts on a two-layered spongy matrix of hyaluronic acid and atelocollagen. @entity3 can be cryopreserved and transported to other hospitals in a frozen state. The present study was designed to analyze the amounts of @entity1 ( @entity1 ) released from fibroblasts in fresh and cryopreserved @entity3 and to investigate the effects of this @entity1 on proliferation of vascular endothelial cells in vitro. The culture medium used in preparing @entity3 (fresh @entity3 @entity3 ) was collected and stored at -30 degrees C for the quantitative analysis of @entity1 . After thawing cryopreserved @entity3 , it was recultured in a culture medium for 1 week. The culture medium used was collected and stored at -30 degrees C for quantitative analysis of @entity1 . The amounts of @entity1 released from the fresh and cryopreserved @entity3 into the culture medium were about 610 pg/ml and 640 pg/ml, respectively. This finding suggests that the cryopreserved @entity3 retains its ability to release @entity1 . Immunohistological analysis indicated that some of the @entity1 adhered to the matrix. @entity0 vascular endothelial cells were cultured in medium mixed with the fresh or cryopreserved @entity3 @entity3 . Proliferation of vascular endothelial cells was enhanced by increasing the concentration of both @entity3 culture medium samples. When antihuman @entity1 antibody was added to the culture medium, the proliferative activity of vascular endothelial cells was reduced. These findings confirm that @entity1 released from @entity3 promotes proliferation of vascular endothelial cells.

title: Effects of @entity1 released from XXXX on proliferation of vascular endothelial cells in vitro.

answer: @entity2


abstract: Allogeneic @entity2 ( @entity3 ) was prepared by culturing fibroblasts on a two-layered spongy matrix of hyaluronic acid and atelocollagen. @entity3 can be cryopreserved and transported to other hospitals in a frozen state. The present study was designed to analyze the amounts of @entity1 ( @entity1 ) released from fibroblasts in fresh and cryopreserved @entity3 and to investigate the effects of this @entity1 on proliferation of vascular endothelial cells in vitro. The culture medium used in preparing @entity3 (fresh @entity3 @entity3 ) was collected and stored at -30 degrees C for the quantitative analysis of @entity1 . After thawing cryopreserved @entity3 , it was recultured in a culture medium for 1 week. The culture medium used was collected and stored at -30 degrees C for quantitative analysis of @entity1 . The amounts of @entity1 released from the fresh and cryopreserved @entity3 into the culture medium were about 610 pg/ml and 640 pg/ml, respectively. This finding suggests that the cryopreserved @entity3 retains its ability to release @entity1 . Immunohistological analysis indicated that some of the @entity1 adhered to the matrix. @entity0 vascular endothelial cells were cultured in medium mixed with the fresh or cryopreserved @entity3 @entity3 . Proliferation of vascular endothelial cells was enhanced by increasing the concentration of both @entity3 culture medium samples. When antihuman @entity1 antibody was added to the culture medium, the proliferative activity of vascular endothelial cells was reduced. These findings confirm that @entity1 released from @entity3 promotes proliferation of vascular endothelial cells.

title: Effects of XXXX released from @entity2 on proliferation of vascular endothelial cells in vitro.

answer: @entity1


abstract: PURPOSE: The aim of this study was to establish the optimal management strategy of @entity3 ( @entity3 ) in early infancy. METHODS: Over the last 15 years, 14 @entity0 with @entity3 in early infancy (within 5 months), including 3 antenatally diagnosed @entity0 , were treated in the authors' department. Of the 14 @entity0 , 7 (50%) underwent early definitive surgery (E group), and the other 7 (50%) underwent delayed primary definitive surgery after percutaneous transhepatic cholangiodrainage (PTCD; D group). Both groups were compared retrospectively using clinical data. RESULTS: Pretreatment status and backgrounds of the @entity0 were clinically homogeneous between the 2 groups. The total length of hospital stay was significantly longer in the D group. As short-term complications, 1 @entity0 in the E group was compromised with hepatolithiasis, and 3 @entity0 in the D group were compromised with catheter-related complications. Other clinical data, such as age at definitive surgery, @entity1 , pathologic @entity5 , @entity4 -free day, and long-term complications were not significantly different between the 2 groups. CONCLUSIONS: The authors propose that the standard of management should be early definitive surgery with wide @entity2 before 2 months of age. However, PTCD might be used under strict consideration of indication and careful management for @entity0 with extremely poor surgical risk.

title: Strategy of management for XXXX in early infancy.

answer: @entity3


abstract: BACKGROUND: The risk of port site metastasis in laparoscopic surgery for @entity1 @entity0 is a problem that has yet to be resolved. We examined the protective effect of a @entity5 -based bioresorbable membrane (Seprafilm) on @entity1 cell implantation at laparoscopic trocar sites. METHODS: Four 2-mm trocar sites were created in @entity2 , and the peritoneal wounds were covered with different-sized pieces of Seprafilm. The protective effect of Seprafilm on the implantation of @entity4 (a @entity0 @entity3 cell line) at the trocar sites was assessed after 7 days. In addition, the effects of @entity5 and Seprafilm on the growth and motility of @entity4 were examined in vitro. RESULTS: Seprafilm significantly decreased the incidence of implantation compared with the control group. Histologically, Seprafilm was observed on days 1 and 3, as a sheet of gel that covered the injured peritoneum and muscle layer. In an invasion assay using Seprafilm, no cells were found to infiltrate through the gel sheet. CONCLUSION: Seprafilm protects peritoneal wounds by physically covering the injured peritoneum. Therefore, if Seprafilm were attached to the injured peritoneum after laparoscopic surgery for @entity1 @entity0 , it might reduce port site metastasis.

title: Protection of trocar sites from @entity3 implantation by XXXX carboxymethylcellulose-based bioresorbable membrane (Seprafilm) in a @entity2 model [corrected].

answer: @entity5


abstract: BACKGROUND: The risk of port site metastasis in laparoscopic surgery for @entity1 @entity0 is a problem that has yet to be resolved. We examined the protective effect of a @entity5 -based bioresorbable membrane (Seprafilm) on @entity1 cell implantation at laparoscopic trocar sites. METHODS: Four 2-mm trocar sites were created in @entity2 , and the peritoneal wounds were covered with different-sized pieces of Seprafilm. The protective effect of Seprafilm on the implantation of @entity4 (a @entity0 @entity3 cell line) at the trocar sites was assessed after 7 days. In addition, the effects of @entity5 and Seprafilm on the growth and motility of @entity4 were examined in vitro. RESULTS: Seprafilm significantly decreased the incidence of implantation compared with the control group. Histologically, Seprafilm was observed on days 1 and 3, as a sheet of gel that covered the injured peritoneum and muscle layer. In an invasion assay using Seprafilm, no cells were found to infiltrate through the gel sheet. CONCLUSION: Seprafilm protects peritoneal wounds by physically covering the injured peritoneum. Therefore, if Seprafilm were attached to the injured peritoneum after laparoscopic surgery for @entity1 @entity0 , it might reduce port site metastasis.

title: Protection of trocar sites from XXXX implantation by @entity5 carboxymethylcellulose-based bioresorbable membrane (Seprafilm) in a @entity2 model [corrected].

answer: @entity3


abstract: BACKGROUND: The risk of port site metastasis in laparoscopic surgery for @entity1 @entity0 is a problem that has yet to be resolved. We examined the protective effect of a @entity5 -based bioresorbable membrane (Seprafilm) on @entity1 cell implantation at laparoscopic trocar sites. METHODS: Four 2-mm trocar sites were created in @entity2 , and the peritoneal wounds were covered with different-sized pieces of Seprafilm. The protective effect of Seprafilm on the implantation of @entity4 (a @entity0 @entity3 cell line) at the trocar sites was assessed after 7 days. In addition, the effects of @entity5 and Seprafilm on the growth and motility of @entity4 were examined in vitro. RESULTS: Seprafilm significantly decreased the incidence of implantation compared with the control group. Histologically, Seprafilm was observed on days 1 and 3, as a sheet of gel that covered the injured peritoneum and muscle layer. In an invasion assay using Seprafilm, no cells were found to infiltrate through the gel sheet. CONCLUSION: Seprafilm protects peritoneal wounds by physically covering the injured peritoneum. Therefore, if Seprafilm were attached to the injured peritoneum after laparoscopic surgery for @entity1 @entity0 , it might reduce port site metastasis.

title: Protection of trocar sites from @entity3 implantation by @entity5 carboxymethylcellulose-based bioresorbable membrane (Seprafilm) in a XXXX model [corrected].

answer: @entity2


abstract: BACKGROUND: Resting regional wall-motion abnormalities do not reliably distinguish @entity1 from nonischemic @entity2 . @entity4 stress echocardiography with use of the @entity7 ( @entity7 ) identifies @entity5 ( @entity5 ) in @entity3 ( @entity3 ), but the technique is subjective and further complicated by @entity6 ( @entity6 ). Long-axis motion is sensitive to @entity1 and can be assessed quantitatively. We aimed to compare long-axis function with @entity7 for detecting @entity5 in @entity3 with or without @entity6 . METHODS AND RESULTS: Seventy-three @entity0 with @entity3 , 48 with @entity5 (16 with @entity6 ), and 25 without @entity5 (10 with @entity6 ) were studied. Long-axis M-mode, pulsed-wave tissue Doppler echograms (lateral, septal, and posterior walls), and @entity7 were assessed at rest and at peak dobutamine stress. Failure to increase systolic amplitude (total amplitude minus postejection shortening) by 2 mm or early diastolic velocity by 1.1 cm/s was the best discriminator for @entity5 (systolic amplitude, sensitivity 85%, specificity 86%; lengthening velocity, 71% and 94%, respectively; P=NS). Both had greater predictive accuracy than did @entity7 (sensitivity 67%, specificity 76%; P<0.001). The predictive accuracy of changes in septal long-axis function was similar to those of average long-axis function (systolic amplitude cutoff=1.5 mm, lengthening velocity cutoff=1.5 cm/s). However in @entity6 , systolic amplitude proved to be the only significant discriminator for @entity5 , with sensitivity and specificity reaching 94% and 100%, respectively (P<0.01 versus early diastolic lengthening velocity). CONCLUSIONS: Quantified stress long-axis function identifies @entity5 in @entity3 with greater sensitivity and specificity than does standard @entity7 , particularly in the presence of @entity6 .

title: Differentiation of @entity1 from nonischemic XXXX during @entity4 stress by left ventricular long-axis function: additional effect of @entity6 .

answer: @entity2


abstract: BACKGROUND: Resting regional wall-motion abnormalities do not reliably distinguish @entity1 from nonischemic @entity2 . @entity4 stress echocardiography with use of the @entity7 ( @entity7 ) identifies @entity5 ( @entity5 ) in @entity3 ( @entity3 ), but the technique is subjective and further complicated by @entity6 ( @entity6 ). Long-axis motion is sensitive to @entity1 and can be assessed quantitatively. We aimed to compare long-axis function with @entity7 for detecting @entity5 in @entity3 with or without @entity6 . METHODS AND RESULTS: Seventy-three @entity0 with @entity3 , 48 with @entity5 (16 with @entity6 ), and 25 without @entity5 (10 with @entity6 ) were studied. Long-axis M-mode, pulsed-wave tissue Doppler echograms (lateral, septal, and posterior walls), and @entity7 were assessed at rest and at peak dobutamine stress. Failure to increase systolic amplitude (total amplitude minus postejection shortening) by 2 mm or early diastolic velocity by 1.1 cm/s was the best discriminator for @entity5 (systolic amplitude, sensitivity 85%, specificity 86%; lengthening velocity, 71% and 94%, respectively; P=NS). Both had greater predictive accuracy than did @entity7 (sensitivity 67%, specificity 76%; P<0.001). The predictive accuracy of changes in septal long-axis function was similar to those of average long-axis function (systolic amplitude cutoff=1.5 mm, lengthening velocity cutoff=1.5 cm/s). However in @entity6 , systolic amplitude proved to be the only significant discriminator for @entity5 , with sensitivity and specificity reaching 94% and 100%, respectively (P<0.01 versus early diastolic lengthening velocity). CONCLUSIONS: Quantified stress long-axis function identifies @entity5 in @entity3 with greater sensitivity and specificity than does standard @entity7 , particularly in the presence of @entity6 .

title: Differentiation of @entity1 from nonischemic @entity2 during XXXX stress by left ventricular long-axis function: additional effect of @entity6 .

answer: @entity4


abstract: BACKGROUND: Resting regional wall-motion abnormalities do not reliably distinguish @entity1 from nonischemic @entity2 . @entity4 stress echocardiography with use of the @entity7 ( @entity7 ) identifies @entity5 ( @entity5 ) in @entity3 ( @entity3 ), but the technique is subjective and further complicated by @entity6 ( @entity6 ). Long-axis motion is sensitive to @entity1 and can be assessed quantitatively. We aimed to compare long-axis function with @entity7 for detecting @entity5 in @entity3 with or without @entity6 . METHODS AND RESULTS: Seventy-three @entity0 with @entity3 , 48 with @entity5 (16 with @entity6 ), and 25 without @entity5 (10 with @entity6 ) were studied. Long-axis M-mode, pulsed-wave tissue Doppler echograms (lateral, septal, and posterior walls), and @entity7 were assessed at rest and at peak dobutamine stress. Failure to increase systolic amplitude (total amplitude minus postejection shortening) by 2 mm or early diastolic velocity by 1.1 cm/s was the best discriminator for @entity5 (systolic amplitude, sensitivity 85%, specificity 86%; lengthening velocity, 71% and 94%, respectively; P=NS). Both had greater predictive accuracy than did @entity7 (sensitivity 67%, specificity 76%; P<0.001). The predictive accuracy of changes in septal long-axis function was similar to those of average long-axis function (systolic amplitude cutoff=1.5 mm, lengthening velocity cutoff=1.5 cm/s). However in @entity6 , systolic amplitude proved to be the only significant discriminator for @entity5 , with sensitivity and specificity reaching 94% and 100%, respectively (P<0.01 versus early diastolic lengthening velocity). CONCLUSIONS: Quantified stress long-axis function identifies @entity5 in @entity3 with greater sensitivity and specificity than does standard @entity7 , particularly in the presence of @entity6 .

title: Differentiation of XXXX from nonischemic @entity2 during @entity4 stress by left ventricular long-axis function: additional effect of @entity6 .

answer: @entity1


abstract: BACKGROUND: Resting regional wall-motion abnormalities do not reliably distinguish @entity1 from nonischemic @entity2 . @entity4 stress echocardiography with use of the @entity7 ( @entity7 ) identifies @entity5 ( @entity5 ) in @entity3 ( @entity3 ), but the technique is subjective and further complicated by @entity6 ( @entity6 ). Long-axis motion is sensitive to @entity1 and can be assessed quantitatively. We aimed to compare long-axis function with @entity7 for detecting @entity5 in @entity3 with or without @entity6 . METHODS AND RESULTS: Seventy-three @entity0 with @entity3 , 48 with @entity5 (16 with @entity6 ), and 25 without @entity5 (10 with @entity6 ) were studied. Long-axis M-mode, pulsed-wave tissue Doppler echograms (lateral, septal, and posterior walls), and @entity7 were assessed at rest and at peak dobutamine stress. Failure to increase systolic amplitude (total amplitude minus postejection shortening) by 2 mm or early diastolic velocity by 1.1 cm/s was the best discriminator for @entity5 (systolic amplitude, sensitivity 85%, specificity 86%; lengthening velocity, 71% and 94%, respectively; P=NS). Both had greater predictive accuracy than did @entity7 (sensitivity 67%, specificity 76%; P<0.001). The predictive accuracy of changes in septal long-axis function was similar to those of average long-axis function (systolic amplitude cutoff=1.5 mm, lengthening velocity cutoff=1.5 cm/s). However in @entity6 , systolic amplitude proved to be the only significant discriminator for @entity5 , with sensitivity and specificity reaching 94% and 100%, respectively (P<0.01 versus early diastolic lengthening velocity). CONCLUSIONS: Quantified stress long-axis function identifies @entity5 in @entity3 with greater sensitivity and specificity than does standard @entity7 , particularly in the presence of @entity6 .

title: Differentiation of @entity1 from nonischemic @entity2 during @entity4 stress by left ventricular long-axis function: additional effect of XXXX .

answer: @entity6


abstract: To evaluate the possibility that @entity5 (S.z) the causative bacterial agent of @entity4 @entity6 (ESFP), as well as to investigate its pathogenesis, 10 @entity4 (seven Thoroughbreds and three Anglo-Arab species, ranging from 2-4 years in age) were experimentally inoculated, via an endoscope, into bronchus of the lung lobe with a dose of 30 ml of 1-7 x 10(8) CFU/ml of S.z. After inoculation, autopsy and pathological examinations were sequentially conducted 30 min, 1, 2, 3, 4, 17, 20 hr and 2 weeks later. @entity1 induced by the intrapulmonary inoculation of S.z was characterized by small purulent pneumonic foci in the inoculated areas. With the lapse of time, these foci developed into @entity3 , @entity3 , and then purulent, coagulation @entity0 . These pathomorphological characteristics of experimental @entity1 closely resemble those naturally occurring ESFP. There is strong evidence that S.z. is implicated as a causal factor in ESFP. S.z. grew in the mucus, exudate, and pulmonary effusions. Further, the bacteria showed resistance against phagocytosis by @entity2 ( @entity2 ) and neutrophils. Inhibition of @entity2 and neutrophil function is considered to be important in the development of @entity1 . With the progression of the disease, the neutrophils often adhered to the endothelial surface of the alveolar capillary lumen and played a role in generating coagulation @entity0 of lung tissues.

title: XXXX in @entity4 induced by intrapulmonary inoculation of Streptococcus equi subsp. @entity5 .

answer: @entity1


abstract: To evaluate the possibility that @entity5 (S.z) the causative bacterial agent of @entity4 @entity6 (ESFP), as well as to investigate its pathogenesis, 10 @entity4 (seven Thoroughbreds and three Anglo-Arab species, ranging from 2-4 years in age) were experimentally inoculated, via an endoscope, into bronchus of the lung lobe with a dose of 30 ml of 1-7 x 10(8) CFU/ml of S.z. After inoculation, autopsy and pathological examinations were sequentially conducted 30 min, 1, 2, 3, 4, 17, 20 hr and 2 weeks later. @entity1 induced by the intrapulmonary inoculation of S.z was characterized by small purulent pneumonic foci in the inoculated areas. With the lapse of time, these foci developed into @entity3 , @entity3 , and then purulent, coagulation @entity0 . These pathomorphological characteristics of experimental @entity1 closely resemble those naturally occurring ESFP. There is strong evidence that S.z. is implicated as a causal factor in ESFP. S.z. grew in the mucus, exudate, and pulmonary effusions. Further, the bacteria showed resistance against phagocytosis by @entity2 ( @entity2 ) and neutrophils. Inhibition of @entity2 and neutrophil function is considered to be important in the development of @entity1 . With the progression of the disease, the neutrophils often adhered to the endothelial surface of the alveolar capillary lumen and played a role in generating coagulation @entity0 of lung tissues.

title: @entity1 in @entity4 induced by intrapulmonary inoculation of Streptococcus equi subsp. XXXX .

answer: @entity5


abstract: To evaluate the possibility that @entity5 (S.z) the causative bacterial agent of @entity4 @entity6 (ESFP), as well as to investigate its pathogenesis, 10 @entity4 (seven Thoroughbreds and three Anglo-Arab species, ranging from 2-4 years in age) were experimentally inoculated, via an endoscope, into bronchus of the lung lobe with a dose of 30 ml of 1-7 x 10(8) CFU/ml of S.z. After inoculation, autopsy and pathological examinations were sequentially conducted 30 min, 1, 2, 3, 4, 17, 20 hr and 2 weeks later. @entity1 induced by the intrapulmonary inoculation of S.z was characterized by small purulent pneumonic foci in the inoculated areas. With the lapse of time, these foci developed into @entity3 , @entity3 , and then purulent, coagulation @entity0 . These pathomorphological characteristics of experimental @entity1 closely resemble those naturally occurring ESFP. There is strong evidence that S.z. is implicated as a causal factor in ESFP. S.z. grew in the mucus, exudate, and pulmonary effusions. Further, the bacteria showed resistance against phagocytosis by @entity2 ( @entity2 ) and neutrophils. Inhibition of @entity2 and neutrophil function is considered to be important in the development of @entity1 . With the progression of the disease, the neutrophils often adhered to the endothelial surface of the alveolar capillary lumen and played a role in generating coagulation @entity0 of lung tissues.

title: @entity1 in XXXX induced by intrapulmonary inoculation of Streptococcus equi subsp. @entity5 .

answer: @entity4


abstract: OBJECTIVE: To evaluate recent data provided on new treatments of @entity0 with @entity6 . DATA EXTRACTION: A Medline search was performed to identify pertinent literature on the pathophysiology of @entity6 and treatment strategies from 1990 to 2003. Keywords were " @entity6 ", " @entity5 ", " @entity1 " and "management". DATA SYNTHESIS: Advances were performed in our current understanding of pathophysiology of @entity5 . The loss of homeostatic balance among the systemic inflammatory response and the disturbance of coagulation with generalized @entity7 lead to organ failures and @entity3 . The administration of activated protein C (drotrecogin alfa) reducing this @entity7 can decrease the mortality of @entity6 @entity0 . The modulation of @entity1 did not make it possible to improve survival of @entity6 @entity0 until now. The efficacy of low doses of @entity2 has been recently shown in @entity6 @entity0 . In addition, new data highlighted the interest of an early goal therapy in @entity0 with @entity5 who are admitted to emergency. CONCLUSION: The improvement of survival in @entity8 @entity0 is a difficult challenge. The uses of different new therapeutic options like protein C reactive, @entity4 , or early goal therapy in association should make it possible to reduce the mortality in septic @entity0 .

title: [Which therapeutic prospects in the XXXX ?].

answer: @entity8


abstract: BACKGROUND: The previous epidemiological study of paediatric @entity4 in Britain was conducted more than 30 years ago. AIMS: To examine the presenting features, predisposing factors, and treatment strategies used in paediatric stones presenting to a British centre over the past five years. METHODS: A total of 121 @entity0 presented with a urinary tract renal stone, to one adult and one paediatric centre, over a five year period (1997-2001). All @entity0 were reviewed in a dedicated stone clinic and had a full infective and metabolic stone investigative work up. Treatment was assessed by retrospective hospital note review. RESULTS: A metabolic abnormality was found in 44% of @entity0 , 30% were classified as infective, and 26% idiopathic. Bilateral stones on presentation occurred in 26% of the metabolic group compared to 12% in the infective/idiopathic group (odds ratio 2.7, 95% CI 1.03 to 7.02). Coexisting @entity2 was common (49%) in the metabolic group. Surgically, minimally invasive techniques (lithotripsy, percutaneous nephrolithotomy, and endoscopy) were used in 68% of @entity0 . CONCLUSIONS: There has been a shift in the epidemiology of @entity1 in the UK over the past 30 years. Underlying metabolic causes are now the most common but can be masked by coexisting @entity2 . Treatment has progressed, especially surgically, with sophisticated minimally invasive techniques now employed. All @entity0 with @entity3 should have a metabolic screen.

title: Epidemiology of XXXX in the UK.

answer: @entity1


abstract: PURPOSE: This research describes the family context of eating and mealtime patterns in young adolescents at high risk for @entity3 2 @entity1 and the implications for preventing this disease. METHODS: Ten families, each consisting of a @entity0 and one parent, participated in individual, semistructured interviews that focused on family eating patterns. Topics included meal schedules, food preparation, family eating patterns, school eating patterns, and perception of the @entity0 's weight. Interviews were audiotaped, transcribed verbatim, and analyzed using focused summaries and thematic analysis methods. RESULTS: Four main themes were identified: @entity0 and family eating patterns, perspectives on @entity2 , perspectives on weight control, and health concerns. Family eating patterns were often inconsistent, and few healthy eating models were available at home or school. Obesity was not always seen as a negative factor, particularly by the youth. Weight-control efforts were sporadic, typically unsuccessful, and consisted primarily of intermittent increases in physical activity. Parents did not actively participate in their @entity0 's weight-control efforts. CONCLUSIONS: Effective interventions for @entity2 and prevention of @entity3 2 @entity1 in youth should include parents in both cognitive and behavioral strategies.

title: The family context of an intervention to prevent XXXX 2 @entity1 in high-risk teens.

answer: @entity3


abstract: PURPOSE: This research describes the family context of eating and mealtime patterns in young adolescents at high risk for @entity3 2 @entity1 and the implications for preventing this disease. METHODS: Ten families, each consisting of a @entity0 and one parent, participated in individual, semistructured interviews that focused on family eating patterns. Topics included meal schedules, food preparation, family eating patterns, school eating patterns, and perception of the @entity0 's weight. Interviews were audiotaped, transcribed verbatim, and analyzed using focused summaries and thematic analysis methods. RESULTS: Four main themes were identified: @entity0 and family eating patterns, perspectives on @entity2 , perspectives on weight control, and health concerns. Family eating patterns were often inconsistent, and few healthy eating models were available at home or school. Obesity was not always seen as a negative factor, particularly by the youth. Weight-control efforts were sporadic, typically unsuccessful, and consisted primarily of intermittent increases in physical activity. Parents did not actively participate in their @entity0 's weight-control efforts. CONCLUSIONS: Effective interventions for @entity2 and prevention of @entity3 2 @entity1 in youth should include parents in both cognitive and behavioral strategies.

title: The family context of an intervention to prevent @entity3 2 XXXX in high-risk teens.

answer: @entity1


abstract: AIMS: Good glycaemic control in hospitalised @entity0 with @entity1 improves wellbeing and aids recovery. This survey aimed to: (1) assess glycaemic control in @entity0 with @entity1 admitted to hospital for reasons other than @entity1 , (2) compare the glycaemic control in @entity0 treated in medical and surgical units, and (3) see the impact of specialists' input on glycaemic control. METHODS: The first 150 @entity0 admitted to hospital were identified; those with acute metabolic complications of @entity1 , @entity2 , @entity5 , and @entity0 in different intensive care units were excluded. Case notes were reviewed with particular attention to glycaemic control, frequency of blood monitoring, complications, and the actions taken to improve glycaemic control. RESULTS: Four of the 150 @entity0 died in hospital. When subcutaneous @entity4 was used glycaemic control was good in 48%, suboptimal in 15%, and poor in 37% of @entity0 . The results were not significantly different with subcutaneous or intravenous @entity4 . There was also no difference in glycaemic control among medical and surgical @entity0 . @entity0 managed by designated specialists had better control than those managed by physicians (p<0.001). Hypoglycaemia was documented in 20% and two @entity0 developed non-ketotic @entity3 while in hospital. In a few cases treatment at discharge was not changed despite poor control while in hospital. CONCLUSION: More attention should be given to improving glycaemic control in @entity0 hospitalised for reasons other than @entity1 . Particular care should be taken to modify the dose of @entity4 needed to get good glycaemic control; control was better with specialists' input. A follow up survey will be conducted.

title: Inpatient management of XXXX : survey in a tertiary care centre.

answer: @entity1


abstract: A retrospective analysis of adult @entity0 who had @entity4 involvement of bone was done to evaluate the prognostic factors and the oncologic outcome. Between 1984 and 1994, 28 @entity0 (nine @entity0 and 19 @entity0 ) were diagnosed with @entity3 . The median age was 45 years (range, 23-76 years). The median followup was 40.3 months (range, 0.5 months-15.8 years). Eighteen @entity0 (64%) were classified as having Stage IE disease, two @entity0 (36%) were classified as having @entity1 , and eight @entity0 were classified as having Stage IV disease. Twenty-one of the lesions were classified as diffuse large B cell with multilobulated nuclei. Two @entity0 had local recurrence. Three @entity0 had @entity5 develop at the site of their radiation therapy. The 5-year Kaplan-Meier survival estimate was 57.8% (95% confidence interval range, 40-33 82.8). Statistically improved survival was seen in @entity0 younger than 40 years and those @entity0 with diffuse large B cell with multilobulated nuclei. @entity0 with primary @entity3 did not have a statistically improved survival compared with @entity0 with @entity2 . The results of the current study suggest that age at diagnosis and histologic subtypes are important prognostic factors; however, the diagnosis of primary @entity3 does not confer improved prognosis.

title: Oncologic outcomes of primary XXXX in adults.

answer: @entity3


abstract: The @entity7 ( @entity7 ) previously also termed smouldering @entity3 , almost always exhibit myeloid differentiation. Very rare cases of hypocellular @entity7 with lymphoid differentiation have been reported, usually in @entity0 . This paper describes two cases (an 87-year-old @entity0 and a 79-year-old @entity0 ) in whom the blood findings were suggestive of @entity7 . @entity2 -embedded bone marrow biopsy specimens revealed similar findings in both @entity0 : there was severe hypocellularity, the cells of normal hemopoiesis were greatly reduced in number, and there was a diffuse increase in blast cells, which represented more than 50% of nucleated marrow cells. The blasts coexpressed @entity11 and @entity4 and were negative for @entity8 , @entity6 , @entity1 and @entity12 esterase. For the first time immunohistochemical @entity9 / @entity4 doublestainings are provided, which revealed the blasts in one case to coexpress @entity9 and @entity4 . All the blasts were @entity10 -positive and 20% were also @entity5 -positive. In the other case, 20% of the blasts were @entity10 -positive, 30% coexpressed @entity9 and @entity4 by doublestaining, and showed a clonal rearrangement of the immunoglobulin heavy chain gene. Thus a diagnosis of @entity7 of lymphoid lineage, hypocellular variant, was made on the basis of immunohistochemical findings. The clinical course appears to be similar to that of @entity7 , as neither @entity0 has developed @entity3 during the one-year follow-up period.

title: Adult hypocellular acute XXXX with lymphoid differentiation.

answer: @entity3


abstract: The open morphogenesis of plants requires coordination of patterning by intercellular signals. The @entity0 ( @entity0 cv Virginia Bright Italia) cell line VBI-0 provides a simple model system to study the role of intercellular communication in patterning. In this cell line, singular cells divide axially to produce linear cell files of distinct polarity. The trigger for this axial division is exogenous auxin. When frequency distributions of files are constructed over the number of cells per file during the exponential phase of the culture, even numbers are found to be frequent, whereas files consisting of uneven numbers of cells are rare. We can simulate these distributions with a mathematical model derived from nonlinear dynamics, which describes a chain of cell-division oscillators where @entity1 are coupled unidirectionally and where the number of oscillators is not conserved. The model predicts several nonintuitive properties of our experimental system. For instance, files consisting of six cells are more frequent than expected from a strictly binary division system. More centrally, the model predicts a polar transport of the coordinating signal. We therefore tested the patterns obtained after treatment with @entity2 , an inhibitor of auxin efflux carriers. Using low concentrations of @entity2 that leave cell division and axiality of division unaltered, we observe that the frequencies of files with even and uneven cell numbers are equalized. Our findings are discussed in the context of auxin transport as synchronizing signal in cell patterning.

title: Auxin transport synchronizes the pattern of cell division in a XXXX cell line.

answer: @entity0


abstract: @entity4 has caused debilitating illness since pre-Incan times, but relatively little is known about its epidemiology. A population-based, prospective cohort investigation was conducted in a Peruvian community with @entity5 . By use of house-to-house and hospital surveillance methods, cohort @entity0 were monitored for evidence of @entity5 . Of 690 @entity0 , 0.5% had asymptomatic @entity2 at study initiation. After 2 years of follow-up, the incidence of @entity1 was 12.7/100 @entity0 -years. The highest rates were in @entity0 <5 years old, and there was a linear decrease in incidence with increasing age. Seventy percent of cases were clustered in 18% of households. Age and @entity5 in a family member were the best predictors of @entity4 @entity1 . There were multiple clinical presentations and significant @entity3 . A cost-effective control strategy should include vector control and surveillance efforts focused on @entity0 and clusters of households with highest endemicity.

title: Epidemiology of endemic XXXX : a prospective cohort study in a Peruvian mountain valley community.

answer: @entity4


abstract: The mechanisms orchestrating spatial cell division control remain poorly understood. In animal cells, the position of the mitotic spindle dictates cleavage furrow placement, and thus plays a key role in governing spatial relationships between resulting daughter cells. The one-cell stage @entity1 embryo is an attractive model system to investigate the mechanisms underlying spindle positioning in metazoans. In this review, the experimental advantages of this model system for an in vivo dissection of cell division processes are first discussed. Next, three lines of experiments that were conducted to dissect the mechanisms governing spindle positioning in one-cell stage @entity1 embryos are summarized. First, localized laser micro-irradiations were utilized to identify the forces acting on spindle poles during anaphase. This work revealed that there is a precise imbalance of pulling forces acting on the two spindle poles, with the forces acting on the posterior spindle pole being in slight excess, thus explaining the asymmetric spindle position achieved by the end of anaphase. Second, an RNAi-based functional genomic screen was carried out to identify novel components required for generating these pulling forces. This uncovered that @entity4 / @entity5 , which encode GoLoco-containing proteins, as well as the previously identified Ga subunits goa-1/ @entity6 , are required for generation of pulling forces on the spindle poles. Third, the @entity7 locus was identified by mutational analysis to play a distinct role during anaphase spindle positioning. @entity7 was found to encode a protein related to @entity0 @entity3 , which is affected in @entity0 with @entity2 . Moreover, @entity7 is a @entity8 that stabilizes microtubules against depolymerization. Together, these experimental approaches contribute to a better understanding of the mechanisms orchestrating spatial cell division control in metazoan organisms.

title: [Mechanisms of cell division: lessons from a XXXX ].

answer: @entity1


abstract: Pericytes are an integral component of blood capillaries, but their involvement in a variety of conditions and diseases, including @entity2 and @entity0 , is poorly understood. In order to analyze the mRNA expression of markers related to @entity2 and @entity0 in @entity1 brain pericytes, we have established brain capillary pericyte cell lines from temperature-sensitive SV40 large T antigen transgenic @entity1 . The newly established clones showed similar biochemical and morphological properties to primary pericytes. The expression of endothelial cell-related markers @entity7 , @entity6 , @entity9 , and @entity8 was evaluated by RT-PCR analysis. beta2-Adrenergic receptor (beta2-AR), @entity4 ( @entity4 ), and klotho were also evaluated as markers related to @entity2 and @entity0 . All of the isolated clones expressed beta2-AR, @entity4 and klotho genes. They also stably expressed @entity7 and @entity8 , while @entity6 , @entity9 and @entity5 were expressed only at low levels in some of the clones. The expressions of @entity4 in TR-PCT1 were determined by Western blotting. @entity3 stimulated migration of pericytes. This effect was blocked by an @entity4 antagonist. The pericyte cell lines established here are pluripotent, and should be useful for analysis of the reactivity and biological roles of pericytes.

title: @entity1 brain pericyte cell lines expressing beta2-adrenergic receptor, @entity3 receptor type 1A, klotho, and XXXX mRNAs despite having endothelial cell markers.

answer: @entity5


abstract: Pericytes are an integral component of blood capillaries, but their involvement in a variety of conditions and diseases, including @entity2 and @entity0 , is poorly understood. In order to analyze the mRNA expression of markers related to @entity2 and @entity0 in @entity1 brain pericytes, we have established brain capillary pericyte cell lines from temperature-sensitive SV40 large T antigen transgenic @entity1 . The newly established clones showed similar biochemical and morphological properties to primary pericytes. The expression of endothelial cell-related markers @entity7 , @entity6 , @entity9 , and @entity8 was evaluated by RT-PCR analysis. beta2-Adrenergic receptor (beta2-AR), @entity4 ( @entity4 ), and klotho were also evaluated as markers related to @entity2 and @entity0 . All of the isolated clones expressed beta2-AR, @entity4 and klotho genes. They also stably expressed @entity7 and @entity8 , while @entity6 , @entity9 and @entity5 were expressed only at low levels in some of the clones. The expressions of @entity4 in TR-PCT1 were determined by Western blotting. @entity3 stimulated migration of pericytes. This effect was blocked by an @entity4 antagonist. The pericyte cell lines established here are pluripotent, and should be useful for analysis of the reactivity and biological roles of pericytes.

title: @entity1 brain pericyte cell lines expressing beta2-adrenergic receptor, XXXX receptor type 1A, klotho, and @entity5 mRNAs despite having endothelial cell markers.

answer: @entity3


abstract: Pericytes are an integral component of blood capillaries, but their involvement in a variety of conditions and diseases, including @entity2 and @entity0 , is poorly understood. In order to analyze the mRNA expression of markers related to @entity2 and @entity0 in @entity1 brain pericytes, we have established brain capillary pericyte cell lines from temperature-sensitive SV40 large T antigen transgenic @entity1 . The newly established clones showed similar biochemical and morphological properties to primary pericytes. The expression of endothelial cell-related markers @entity7 , @entity6 , @entity9 , and @entity8 was evaluated by RT-PCR analysis. beta2-Adrenergic receptor (beta2-AR), @entity4 ( @entity4 ), and klotho were also evaluated as markers related to @entity2 and @entity0 . All of the isolated clones expressed beta2-AR, @entity4 and klotho genes. They also stably expressed @entity7 and @entity8 , while @entity6 , @entity9 and @entity5 were expressed only at low levels in some of the clones. The expressions of @entity4 in TR-PCT1 were determined by Western blotting. @entity3 stimulated migration of pericytes. This effect was blocked by an @entity4 antagonist. The pericyte cell lines established here are pluripotent, and should be useful for analysis of the reactivity and biological roles of pericytes.

title: XXXX brain pericyte cell lines expressing beta2-adrenergic receptor, @entity3 receptor type 1A, klotho, and @entity5 mRNAs despite having endothelial cell markers.

answer: @entity1


abstract: In analysis of the integrated program of the Maternal @entity0 Health Program the need for protection against disease and pre and post-natal care were highlighted. The data analysed came from the district of Sultanpar in Uttar Pradesh, India. The reference period was from 1st April 1976 to 15th January 1978. The Auxiliary Nurse Midwife is expected to provide services for about 5 villages, with the help of trained dais (midwives). In order to assess program effectiveness data was collected from cards kept on mothers and @entity0 by the @entity5 . It was found that 70% of births were not registered by the @entity5 and so did not receive @entity4 services; the majority of deliveries were still conducted by untrained dais, not the @entity5 . Though the ante-natal immunization for @entity1 and @entity3 tablets against @entity2 are a very important aspect of maternal- @entity0 services the majority of @entity0 were not so protected. Very few @entity0 received Diptheria, Polio, @entity1 immunization. This may be due to the reluctance on the part of the parents to immunize their @entity0 in the 1st year of life. It is also stated that the stress on acceptance of family planning may be to the detriment of the @entity4 programs. It is suggested that the trained dai work closely with the @entity5 . The medical training officer of the primary health center should work out the most effective approach for such cooperation. Strict and careful supervision would also be effective. The @entity1 toxoid immunization should be streamlined for maximum coverage. Awareness of the necessity of immunization should be created through media and publicity programs.

title: Effectiveness of auxiliary nurse midwife in delivering XXXX service.

answer: @entity4


abstract: The aim of this study was to retrospectively analyze the clinical and pathologic data of a series of @entity0 presenting to our unit with uterine malignant mixed @entity2 ( @entity7 ) to attempt to identify prognostic factors and relate them to survival. Thirty-seven @entity0 diagnosed with @entity7 of the uterus from 1988 through 2000 were identified from the gynecological @entity2 registry. Data was abstracted and analyzed. The effect of a variety of clinical, histopathologic, and surgical variables on recurrence and survival were analyzed by univariate and multivariate analyses. @entity0 tended to be postmenopausal, overweight, @entity5 , and presented with @entity6 . Preoperatively 28 (76%) were thought to have clinical stage I-II disease. Nine (32%) were upstaged based on surgical data. Five (56%) of these @entity0 were found to have gross extrauterine disease and four (44%) were found subsequently to have microscopic extrauterine disease. Twenty (54%) @entity0 underwent lymph node dissection and positive nodes were found in seven (35%) @entity0 . Nine @entity0 underwent omentectomy and disease was found in three (33%). Peritoneal washings were positive in three of 16 @entity0 (19%). At the completion of primary surgery, 27 (75%) @entity0 had no @entity4 . Twelve (44%) of these @entity0 had recurrence of disease. Median disease-free interval prior to first recurrence was 15 months. Median overall survival was 30 months. Log-rank analysis performed on multiple variables, including stage, age, @entity4 , and depth of @entity1 showed a statistically significant association with overall survival probability. Only stage remained a significant independent variable predictive of overall survival (P = 0.034). We found that stage was an independent prognostic factor for overall survival in @entity0 with uterine @entity7 . Age, depth of @entity1 , and @entity3 were significant prognostic factors on univariate analysis. These factors may be a guide in order to select a group of high risk @entity0 that may benefit from adjuvant therapy.

title: Analysis of clinicopathologic factors in malignant mixed XXXX of the uterine corpus.

answer: @entity2


abstract: OBJECTIVE: It was the aim of this study to investigate the expression of topoisomerase IIalpha (topo IIalpha), Ki-67, @entity5 ( @entity5 ), @entity2 , and argyrophilic nucleolar organizer region (AgNOR) staining in @entity7 ( @entity7 , N = 10), @entity7 ( @entity7 , N = 24), @entity6 ( @entity6 , N = 26), as well as @entity3 ( @entity3 , N = 22) of the vulva. METHODS: Formalin-fixed, @entity4 -embedded archival tissue sections were immunostained with monoclonal antibodies against topo IIalpha, @entity2 , and @entity5 , as well as an affinity-isolated prediluted ready-to-use Ki-67 antibody using a standard immunohistochemical method, and stained with a colloid @entity1 solution for AgNORs. Immunostaining was quantitated by determining the percentage of positively staining nuclei in each sample to express the labeling indices (LIs) by counting the immunoreactive nuclei in 1000 epithelial cells per case for each antibody. In each specimen 200 nuclei were examined using a x100 oil emersion lens, and the mean number of AgNORs per nucleus (AC) was calculated. RESULTS: The LIs for topo IIalpha, Ki-67, and @entity5 as well as ACs increased stepwise from @entity7 to VCs, @entity7 , and SCCs. In contrast to @entity5 LIs and ACs, a consistent correlation in all four groups was found for Ki-67 and topo IIalpha, suggesting that the latter is a proliferation-associated marker in these tissues. @entity2 expression was seen 8.3% of VCs, 30.8% of @entity7 , and 54.45% of SCCs. @entity2 LIs were not correlated with LIs for topo IIalpha or Ki-67 in SCCs. The LIs for topo IIalpha, Ki-67, @entity5 , @entity2 , and ACs were not related to @entity0 progression, FIGO stage, or @entity0 grade in SCCs. CONCLUSIONS: This study presents topo IIalpha and Ki-67 as useful proliferation-associated markers of @entity7 .

title: Expression of topoisomerase IIalpha, Ki-67, @entity5 , XXXX , and argyrophilic nucleolar organizer regions in vulvar squamous lesions.

answer: @entity2


abstract: OBJECTIVE: It was the aim of this study to investigate the expression of topoisomerase IIalpha (topo IIalpha), Ki-67, @entity5 ( @entity5 ), @entity2 , and argyrophilic nucleolar organizer region (AgNOR) staining in @entity7 ( @entity7 , N = 10), @entity7 ( @entity7 , N = 24), @entity6 ( @entity6 , N = 26), as well as @entity3 ( @entity3 , N = 22) of the vulva. METHODS: Formalin-fixed, @entity4 -embedded archival tissue sections were immunostained with monoclonal antibodies against topo IIalpha, @entity2 , and @entity5 , as well as an affinity-isolated prediluted ready-to-use Ki-67 antibody using a standard immunohistochemical method, and stained with a colloid @entity1 solution for AgNORs. Immunostaining was quantitated by determining the percentage of positively staining nuclei in each sample to express the labeling indices (LIs) by counting the immunoreactive nuclei in 1000 epithelial cells per case for each antibody. In each specimen 200 nuclei were examined using a x100 oil emersion lens, and the mean number of AgNORs per nucleus (AC) was calculated. RESULTS: The LIs for topo IIalpha, Ki-67, and @entity5 as well as ACs increased stepwise from @entity7 to VCs, @entity7 , and SCCs. In contrast to @entity5 LIs and ACs, a consistent correlation in all four groups was found for Ki-67 and topo IIalpha, suggesting that the latter is a proliferation-associated marker in these tissues. @entity2 expression was seen 8.3% of VCs, 30.8% of @entity7 , and 54.45% of SCCs. @entity2 LIs were not correlated with LIs for topo IIalpha or Ki-67 in SCCs. The LIs for topo IIalpha, Ki-67, @entity5 , @entity2 , and ACs were not related to @entity0 progression, FIGO stage, or @entity0 grade in SCCs. CONCLUSIONS: This study presents topo IIalpha and Ki-67 as useful proliferation-associated markers of @entity7 .

title: Expression of topoisomerase IIalpha, Ki-67, XXXX , @entity2 , and argyrophilic nucleolar organizer regions in vulvar squamous lesions.

answer: @entity5


abstract: OBJECTIVES: In the case of recurrent @entity2 , salvage therapy represents the potential to trade off between quality and quantity of life. @entity0 and physician face a choice between chemotherapy directed at slowing disease progression and supportive or palliative care that focuses on symptom management. To date, no studies have investigated the effects of best supportive care on @entity2 @entity0 ' quality of life and length of life as compared to salvage therapy. In other @entity1 , both quantity and quality of life considerations have been shown to affect treatment preferences. METHODS: Using a decision board, we assessed preferences for salvage therapy or palliative care in the case of recurrent @entity2 among 81 @entity2 @entity0 receiving first-line chemotherapy and 75 Noncancer Controls. RESULTS: Compared to Noncancer Controls, @entity2 @entity0 overwhelmingly preferred salvage therapy; quantity of life was of primary importance. In both groups, preference was not related to age, marital status, number of @entity0 , or employment status. On average, @entity0 indicated they would switch from salvage therapy to palliative care when the median survival associated with salvage therapy was reduced to 5 months. Noncancer Controls would switch significantly sooner, when the median increment in survival period was reduced to 8 months. Switchpoint was not associated with life satisfaction, quality of life, or psychological or spiritual well-being in either group. CONCLUSIONS: The majority of @entity0 , independent of a @entity1 diagnosis, indicated a desire for continuing aggressive treatment, despite poor outcomes. Quality of life was of secondary importance, especially among @entity2 @entity0 .

title: Treatment preferences in recurrent XXXX .

answer: @entity2


abstract: Broiler chicks aged 12 h after hatching were allotted according to a block design in a 7 x 2 factorial schedule of 14 treatments and four replications of 50 chicks each one. The main experimental factors were fasting for 0, 6, 12, 18, 24, 30, and 36 h after @entity2 placement and sex. Independent of sex, fasting had a negative linear effect on weight and productivity of broilers at market age (42 d) without affecting feed conversion or mortality index. Groups subjected to 18 and 36 h of fasting after placement, corresponding to 30 and 48 h posthatching fasting, had lower biometrical values for small intestine (length, weight, and size; villus height; and crypt depth) than chicks fed immediately after placement. According to the Pearson test, BW of birds at 21 and 42 d were significantly correlated to BW at 7 d (r=0.77) and 21 d (r=0.45), respectively. Males performed better than females but had higher mortality rates. Fasting did not influence serum concentrations of @entity3 or sexual @entity1 hormones. Nevertheless, early signs of sexual dimorphism arose from the high @entity0 (E2) concentration on female serum. Heterophil:lymphocyte ratio was not different among treatments, indicating that early fasting did not seem to be a stress factor 21 or 42 d after fasting. The results suggested a maximum fasting of 24 h after hatching in order to preserve @entity4 at market age.

title: Performance and physiological parameters of broiler XXXX subjected to fasting on the neonatal period.

answer: @entity2


abstract: Volatile anesthetics enhance the @entity7 produced by nondepolarizing muscle relaxants (NDMRs). The neuromuscular junction is a postulated site of this interaction. We tested the hypothesis that volatile anesthetic enhancement of @entity1 is the result of combined drug effects on the nicotinic @entity2 receptor. The adult @entity0 muscle nicotinic @entity2 receptor (alpha(2), beta, delta, epsilon) was heterologously expressed in @entity3 oocytes. Concentration-effect curves for the inhibition of @entity2 -induced currents were established for @entity6 , @entity5 , @entity8 , and @entity4 . Subsequently, inhibitory effects of NDMRs were studied in the presence of the volatile anesthetics at a concentration equivalent to half the concentration producing a 50% inhibition alone. All individually tested compounds produced rapid and readily reversible concentration-dependent inhibition. The calculated 50% inhibitory concentration values were 9.9 nM (95% confidence interval [CI], 8.4-11.4 nM), 43.4 nM (95% CI, 33.6-53.3 nM), 897 microM (95% CI, 699-1150 microM), and 818 microM (95% CI, 685-1001 microM) for @entity6 , @entity5 , @entity8 , and @entity4 , respectively. Coapplication of either @entity8 or @entity4 significantly enhanced the inhibitory effects of @entity6 and @entity5 , especially so at small concentrations of NDMRs. Volatile anesthetics increase the potency of NDMRs, possibly by enhancing antagonist affinity at the receptor site. This effect may contribute to the clinically observable enhancement of @entity7 by volatile anesthetics. IMPLICATIONS: @entity8 and @entity4 enhance the receptor blocking effects of nondepolarizing muscle relaxants on nicotinic @entity2 receptors.

title: Characterization of the interactions between volatile anesthetics and neuromuscular blockers at the muscle nicotinic XXXX receptor.

answer: @entity2


abstract: OBJECTIVE: To present the main results of the investigation of an outbreak of @entity3 that occurred in an inner city district of Barcelona between 15 October and 15 November 2000. METHODS: Epidemiological surveys of @entity0 and environmental investigations were initiated on the day the first five cases were notified. Water samples and smears from cooling tower trays were taken for microbiological analysis. Maps of the distribution of cases and possible contamination foci were elaborated. Incidences were calculated for each census tract. RESULTS: A total of 54 @entity0 related to the outbreak were identified, with a case fatality rate of 5.5%. Incidence rate in the area closest to the cooling tower (6.40/1000) was significantly higher than that of the rest of the neighbourhood (2.23/1.000, RR 2.87, 95%CI 1.37-6.12, P = 0.0035). Cultures positive for @entity2 serogroup 1, subtypes Pontiac, Philadelphia or Allentown, were obtained from eight @entity0 . On the 39th day of the investigation it was found that the strain isolated in one of the cooling towers coincided with the serogroup, subtype and molecular profiles identified in clinical samples. CONCLUSIONS: Rapid coordination of clinicians, microbiologists, epidemiologists and environmentalists permitted the source of @entity1 and the affected cases to be correlated within a few days.

title: An outbreak of XXXX in an inner city district: importance of the first 24 hours in the investigation.

answer: @entity3


abstract: CONTEXT: Lack of a valid classification of severity of @entity2 and the absence of longitudinal data on which to base an opinion have made it difficult to consider prognostic issues accurately. OBJECTIVE: To describe patterns of gross motor development of @entity0 with @entity2 by severity, using longitudinal observations, as a basis for prognostic counseling with parents and for planning clinical management. DESIGN: Longitudinal cohort study of @entity0 with @entity2 , stratified by age and severity of motor function and observed serially for up to 4 years during the period from 1996 to 2001. SETTING: Nineteen publicly funded regional @entity0 's ambulatory rehabilitation programs in Ontario. @entity0 : A total of 657 @entity0 aged 1 to 13 years at study onset, representing the full spectrum of clinical severity of @entity1 in @entity0 with @entity2 . MAIN OUTCOME MEASURES: Severity of @entity2 , classified with the 5-level Gross Motor Function Classification System; function, formally assessed with the Gross Motor Function Measure (GMFM). RESULTS: Based on a total of 2632 GMFM assessments, 5 distinct motor development curves were created; these describe important and significant differences in the rates and limits of gross motor development among @entity0 with @entity2 by severity. There is substantial within-stratum variation in gross motor development. CONCLUSIONS: Evidence-based prognostication about gross motor progress in @entity0 with @entity2 is now possible, providing parents and clinicians with a means to plan interventions and to judge progress over time. Further work is needed to describe motor function of adolescents with @entity2 .

title: Prognosis for gross motor function in XXXX : creation of motor development curves.

answer: @entity2


abstract: OBJECTIVE: In this study, we tested the hypothesis that @entity7 serum @entity6 is higher in nonobese black adults than in white adults and that high @entity7 @entity6 predicts @entity3 2 @entity1 equally well in both groups. RESEARCH DESIGN AND METHODS: At the baseline examination (1987-1989) of the @entity5 Risk in Communities Study, @entity7 @entity6 and BMI were measured in 13,416 black and white @entity0 and @entity0 without @entity1 . @entity0 were examined at years 3, 6, and 9 for incident @entity1 based on @entity7 @entity4 and American @entity1 Association criteria. RESULTS: Fasting @entity6 was 19.7 pmol/l higher among nonobese (BMI <30 kg/m(2)) black @entity0 compared with white @entity0 (race and @entity2 interaction term, P < 0.01). There were no differences among @entity0 . Among nonobese @entity0 , the relative risk for developing @entity1 was similar between racial groups: 1.4 (95% CI 1.2-1.5) and 1.3 (1.2-1.4) per 60 pmol/l increase in @entity6 (P < 0.01) for black and white @entity0 , respectively (interaction term, P = 0.6). Findings were similar among @entity0 . Adjusting for established risk factors did not attenuate this association. CONCLUSIONS: Nonobese black @entity0 have higher @entity7 @entity6 levels than nonobese white @entity0 , and @entity7 @entity6 is an equally strong predictor of @entity1 in both groups. These results suggest one mechanism to explain the excess incidence of @entity1 @entity0 but do not explain the excess among black @entity0 . Future research should evaluate additional factors: genetic, environmental, or the combination of both, which might explain higher @entity7 @entity6 among black @entity0 when compared with white @entity0 .

title: Serum @entity6 , @entity2 , and the incidence of XXXX 2 @entity1 in black and white adults: the @entity5 risk in communities study: 1987-1998.

answer: @entity3