abstract: Thirty @entity0 with @entity6 ( @entity6 ) were observed at a @entity4 clinic between 1970 and 2000. Disease onset was at the mean age (SD) of 14.5 (+/-5.9) years. Presentation with @entity2 occurred in 12 of 30 @entity0 and with @entity1 in 15. Three @entity0 were asymptomatic at the time of diagnosis. The mean (SD) delay to diagnosis was 5.9 (+/-5.7) years. Five @entity0 diagnosed in an advanced stage of disease died before initiating treatment. Eighteen @entity0 were followed and treated with @entity7 alone or in combination with @entity11 . Treatment improved most of @entity1 . @entity8 , @entity3 and @entity10 were the most resistant neurological signs. 'Pseudo- @entity9 ' neurologic involvement predicted a good outcome, whereas hepatic onset and 'classic' neurologic involvement were associated with a poorer prognosis. Two of the 18 treated @entity0 died of @entity5 due to voluntary discontinuation of therapy. Both @entity7 and @entity11 were well tolerated. No teratogenic effect of @entity7 was observed throughout 5 pregnancies. Our results suggest that @entity7 or a combination of @entity7 and @entity11 is a safe and effective long-term treatment in @entity0 with @entity6 .

title: Clinical presentation and treatment of XXXX : a single-centre experience.

answer: @entity6


abstract: The cognitive performance of 47 elderly @entity3 @entity0 with onset of symptoms in late life (late @entity4 ) was compared to that of 33 controls matched for age, sex, ethnic origin, number of years of education, and pre-morbid IQ as measured by the NART. Neuropsychological indices of general cognitive functioning (MMSE, CAMCOG, WAIS-R verbal and performance scores) showed that @entity0 were performing the tasks at a significantly lower level than controls. @entity0 also showed a trend to have a lower span capacity than controls, particularly at the spatial span subtest. There was no obvious impairment of learning as measured by the digit and spatial recurring span tasks nor of simultaneous matching-to-sample ability. However, @entity0 ' performance on a delayed-matching-to-sample procedure was significantly worse than that of controls. In addition, @entity0 performed worse than controls on the Recognition Memory Test for Faces, but not for Words. Finally, the performance of @entity0 on tests assessing executive functioning (Verbal Fluency Test, Computerized Extra and Intra-Dimensional Shift Task, Computerized Spatial Working Memory Task, and Computerized Tower of London Task) was consistently worse than that of controls. These results suggest that @entity3 states arising in late life are predominantly associated with a decline on measures of general cognitive ability and executive functioning. The neuropsychological meaning of these findings is discussed in the light of cognitive models of @entity3 , as well as of @entity1 and @entity2 research. We concluded that the lack of a clear pattern of impairment among these @entity0 may be the result of their clinical and cognitive diversity.

title: Cognitive features of @entity3 states arising in late life (late XXXX ).

answer: @entity4


abstract: The cognitive performance of 47 elderly @entity3 @entity0 with onset of symptoms in late life (late @entity4 ) was compared to that of 33 controls matched for age, sex, ethnic origin, number of years of education, and pre-morbid IQ as measured by the NART. Neuropsychological indices of general cognitive functioning (MMSE, CAMCOG, WAIS-R verbal and performance scores) showed that @entity0 were performing the tasks at a significantly lower level than controls. @entity0 also showed a trend to have a lower span capacity than controls, particularly at the spatial span subtest. There was no obvious impairment of learning as measured by the digit and spatial recurring span tasks nor of simultaneous matching-to-sample ability. However, @entity0 ' performance on a delayed-matching-to-sample procedure was significantly worse than that of controls. In addition, @entity0 performed worse than controls on the Recognition Memory Test for Faces, but not for Words. Finally, the performance of @entity0 on tests assessing executive functioning (Verbal Fluency Test, Computerized Extra and Intra-Dimensional Shift Task, Computerized Spatial Working Memory Task, and Computerized Tower of London Task) was consistently worse than that of controls. These results suggest that @entity3 states arising in late life are predominantly associated with a decline on measures of general cognitive ability and executive functioning. The neuropsychological meaning of these findings is discussed in the light of cognitive models of @entity3 , as well as of @entity1 and @entity2 research. We concluded that the lack of a clear pattern of impairment among these @entity0 may be the result of their clinical and cognitive diversity.

title: Cognitive features of XXXX states arising in late life (late @entity4 ).

answer: @entity3


abstract: This study aimed to explore the heterogeneity of @entity2 with onset in late life by using cognitive factors in a centroid method of cluster analysis. Forty-seven subjects were allocated to two different clusters, the first with 24 (51.1%) and the second with 23 (48.9%) @entity0 . Their cognitive attainment was evaluated against the performance of 33 elderly controls, all groups being matched for age, sex, and the numbers of years of education. @entity0 in cluster 2 showed a pattern of widespread @entity1 , which involved general measures of cognitive performance (MMSE, CAMCOG, WAIS-R verbal and performance scores), memory (digit and spatial span, delayed matching-to-sample, recognition memory for words and faces), and executive functions (verbal fluency, extra and intra-dimensional shift ability, spatial working memory, and planning). In contrast, @entity0 in cluster 1 were only impaired on their extra-dimensional set shift and planning abilities, suggesting a more specific and restricted executive functioning deficit. We also analysed the impact that the use of antipsychotic medication could have had on @entity0 ' cognitive performance, which was shown to be negligible. In addition, there was no difference between the clusters with regard to the number of @entity0 using neuroleptics, suggesting that the medication was unlikely to have introduced a performance bias in the two @entity0 clusters. The validity of the subdivision of these @entity0 into two separate groups was further supported by other clinical findings. @entity0 in cluster 1 exhibited more severe @entity2 , as measured by the SAPS, than their counterparts in cluster 2, and were also more likely to display first-rank symptoms of Schneider. Conversely, cluster 2 membership was strongly associated with the presence of neurological signs and negative symptoms. We suggest that @entity2 states arising in late life are a heterogeneous condition that may be best divided in two: 'type A', including @entity0 with a wide range of @entity2 , mild increase in the frequency of neurological signs, and @entity1 restricted to executive functions, and 'type B', which includes @entity0 with less complex @entity2 associated with a marked increase in the frequency of neurological signs and generalized @entity1 . The basis for this subdivision and the prospect for future studies are discussed.

title: Clinical and cognitive diversity of XXXX states arising in late life (late paraphrenia).

answer: @entity2


abstract: An experimental model system is presented that allows the identification and follow-up of @entity1 exposed to ionizing radiation using flow-cytometric measurements of peripheral blood cells. In an experiment, properties of peripheral blood cells were analysed with flow cytometry for a rapid identification of individuals exposed to radiation. Individuals were then followed longitudinally in an attempt to identify those developing @entity0 . Male CBA @entity1 , 25 days old, were subjected to fractionated x-irradiation (4 x 1.31 Gy) to induce @entity0 . By repeated blood sampling followed by flow cytometry, frequencies of micronucleated erythrocytes and of proliferating nucleated cells were determined. @entity0 were diagnosed by histopathology. Five days after the end of radiation exposure, increased frequencies of proliferating cells, polychromatic erythrocytes and micronucleated normochromatic erythrocytes clearly distinguished the exposed group from the control group. Increased cell proliferation in peripheral blood cells could be used to identify animals with @entity0 , although these animals were at a late stage of @entity0 development. Animals with @entity2 (not generalized) could not be identified with the flow-cytometric parameters used. We consider that this model system has a potential use when a small number of risk individuals need to be identified and monitored within a large population.

title: Flow-cytometric identification and follow-up of XXXX exposed to x-irradiation: evaluation of a model system.

answer: @entity1


abstract: The gef gene, found in @entity2 DNA, encodes a small (50 @entity4 ) protein which is related to cell-killing functions. We used the MS-36 @entity1 cell line as an experimental model to examine the usefulness of the gef gene as a new strategy for @entity0 therapy. We transfected MS-36 cells using the pMAMneo vector, and induced gef gene expression with @entity3 . This decreased the proliferation rate of MS-36TG by as much as 85% in comparison with MS-36 parental cells. The decrease in cell growth was accompanied with significant modifications of the cell cycle and morphology. The G1-phase gradually disappeared, with accumulation in the S-phase. However, studies with annexin V- @entity5 and @entity6 failed to demonstrate induction of apoptosis. Morphological changes were an increase in cell size and the number of filopodia, and especially the appearance of pore-like alterations in the cell membrane which were not seen in parental cells. Our results demonstrate that the gef gene, a system independent of the administration of a prodrug, significantly reduces the proliferation of MS-36 cells. This gene may therefore be considered a new candidate for @entity0 gene therapy.

title: Transfection of MS-36 XXXX cells with gef gene inhibits proliferation and induces modulation of the cell cycle.

answer: @entity1


abstract: PURPOSE: To determine the growTH rate and behavior of small (< or = 3.5-cm diameter) incidentally detected @entity3 . MATERIALS AND METHODS: Forty renal @entity2 in 37 adult @entity0 (mean age, 65.5 years) were observed with computed tomography (CT) and ultrasound for 1.75-8.5 years (mean, 3.25 years). Surgical removal was performed of 26 @entity2 proved and graded at pathologic examination. @entity2 with CT criteria of @entity2 are being followed up. RESULTS: The overall growth rate of @entity2 was 0-1.1 cm/y (mean, 0.36 cm/y). Thirty @entity2 grew 0.5 cm/y or less and 19 grew very slowly (< or = 0.35 cm/y). No @entity0 developed @entity1 . Nine (24%) had multiple @entity2 . CONCLUSION: Most small, incidentally discovered, well-marginated @entity3 grow slowly and are not an immediate threat to a @entity0 's life. Watchful waiting might be appropriate instead of surgical removal, especially in @entity0 who are elderly or may not survive surgery.

title: Small XXXX : further observations on growth.

answer: @entity3


abstract: PURPOSE: To evaluate @entity2 resectability with computed tomography (CT) or magnetic resonance (MR) imaging. MATERIALS AND METHODS: Eighty-two @entity0 underwent CT (n = 43) or MR imaging (n = 50); eleven of these 82 underwent both. Imaging was performed within 4 weeks of surgical staging. Radiologic, surgical, and histopathologic findings were compared. RESULTS: Overall staging accuracy was similar for CT and MR imaging (77% [33 of 43] vs 78% [39 of 50]). Evaluation of pelvic @entity1 extent was better with MR imaging than with CT. There was no difference in detection of abdominal disease. Most mesenteric and small-bowel implants were not detected with either CT or MR imaging. For CT, the positive predictive value for @entity1 nonresectability was 100% (three of three @entity0 ); the negative predictive value was 92% (37 of 40 @entity0 ). The positive and negative predictive values for MR imaging were 91% (10 of 11 @entity0 ) and 97% (38 of 39 @entity0 ). CONCLUSION: While the staging accuracy of both CT and MR imaging is only moderate, prediction of @entity1 resectability is excellent.

title: XXXX : staging with CT and MR imaging.

answer: @entity2


abstract: OBJECTIVE: In @entity2 , early suppression of the viral load in the central nervous system is critical for the efficacy of antiretroviral therapy, in order to prevent the emergence of a reservoir of resistant strains of virus, and @entity0 in late stages of the @entity1 . The blood-cerebrospinal fluid (CSF) interface (i.e. the choroidal epithelium) constitutes the most direct route to reach the ventricular meningeal and perivascular infected macrophages, and may modulate the cerebral biodisposition of antiretroviral drugs through various transport systems. Our aim was to address @entity4 drug transfer specifically across the blood-CSF interface, and identify the possible mechanisms involved in their transport. METHODS: Drug influx and efflux were measured using an in vitro cellular model that reproduces the barrier and transport properties of the blood-CSF interface in vivo. Transport mechanisms were investigated by competition studies. RESULTS: The CSF influx rate of @entity5 was the highest, although moderate, followed by that of @entity7 . The permeability coefficients of the other drugs tested were low. @entity5 influx into the CSF is independent of @entity3 transport systems, and more importantly is limited by an efflux mechanism. This efflux involves an apical (CSF-facing) carrier belonging to the solute carrier (Slc) 22 family of organic anion transporters, and can be inhibited by a therapeutic concentration of @entity6 . CONCLUSIONS: The demonstration and characterization of this efflux mechanism is the basis for the development of specific inhibitory agents in view to increase the delivery of antiretroviral @entity4 analogs to the brain.

title: Choroid plexus controls brain availability of anti-HIV XXXX analogs via pharmacologically inhibitable organic anion transporters.

answer: @entity4


abstract: BACKGROUND: Preeclampsia is @entity2 that occurs after the 20th week of gestation in pregnancy and is characterized by @entity1 and @entity3 . In Africa more than 270,000 @entity0 die from maternal deaths, worldwide approximately 76,000 @entity0 and 500,000 babies die yearly due to @entity4 . It affects about 8-10  % of all pregnancies. Studies have shown that up to 77  % @entity0 affected with @entity4 lack knowledge about @entity4 , and therefore cannot take preventative measures. The aim of study is to evaluate the outcomes and quality of care given to preeclamptic @entity0 treated in Dilla University Referral Hospital. METHODS: The study is a retrospective, hospital based study. One hundred and seventy two records of @entity0 were retained for final study out of 7702 @entity0 from January 2009 to December 2012. RESULTS: The incidence rate of @entity4 in Dilla University Referral Hospital was found to be 2.23  %. The common mean ages found to be affected for @entity4 were 19.2, 22.5 and 27.8 and 31.5 with a trend towards increasing severity with younger age population. CONCLUSION: A guideline on the management and prevention of @entity4 needs to be produced for Ehiopia.

title: Assessment of prevalence of XXXX from Dilla region of Ethiopia.

answer: @entity4


abstract: UNASSIGNED: Cestodes or tapeworms belong to a diverse group of helminths. The adult @entity5 and @entity2 tapeworm can infest the @entity0 gut and the larval stage of Echinococcus spp. and @entity2 can infect tissues of the @entity0 body, causing serious disease. Molecular diagnostics can be performed on proglottids, eggs and on cyst fluids taken by biopsy. Detection of @entity4 when a @entity1 is suspected is of vital importance and species determination is required for appropriate @entity0 care. For routine diagnostics a single test that is able to detect and type a range of @entity4 is preferable. We sought to improve our diagnostic procedure that used to rely on PCR and subsequent sequencing of the @entity3 and Nad1 genes. We have compared these PCRs with novel PCRs on the 12S rRNA and Nad5 gene and established the sensitivity and specificity. A single PCR on the 12S gene proved to be very suitable for detection and specification of Taenia sp. and Echinococcus sp. Both targets harbour enough polymorphic sites to determine the various Echinococcus species. The 12S PCR was most sensitive of all tested.

title: Novel PCRs for differential diagnosis of XXXX .

answer: @entity4


abstract: The apexcardiogram (acg), when recorded serially in @entity0 with @entity3 ( @entity3 ), @entity6 ( @entity6 ) and stable @entity4 ( @entity4 ), appeared to reflect the abnormal patterns of contraction of the left ventricle in these conditions. Thus, @entity7 (dyskinesis) of the systolic wave or increased "a" wave amplitude with gradual recovery over several weeks was found in all 60 @entity0 with documented @entity3 and in 18 of 20 @entity0 with @entity6 . Electrocardiogram changes were noted, however, in only eight of the @entity6 @entity0 . Changes in the acg frequently antedated @entity1 in the ecg. Paradoxical bulging of the systolic wave of the acg was additionally noted in @entity0 during the @entity5 but this promptly disappeared after the administration of @entity8 . @entity0 with @entity5 often had normal resting ecg's but abnormal resting acg's. In contrast to the relatively transient abnormalities noted above, the acg remained unchanged in most @entity0 with stable @entity4 during follow-up of three months to two years. @entity0 undergoing coronary bypass operations, however, showed immediate improvement in the acg in the postoperative period. These results suggest the acg reflects the contractile pattern of the left ventricle, and may be an indirectly recorded ventriculogram. Its enhanced sensitivity and the earlier development of changes in comparison to the ecg make this a valuable tool in the study of @entity0 with @entity2 .

title: The apexcardiogram in XXXX .

answer: @entity4


abstract: BACKGROUND: Standard of care for @entity0 with advanced @entity3 includes administration of neoadjuvant chemotherapy (NAC) before resection. This study assesses the pattern of use and impact of NAC on perioperative outcomes in US medical centers. METHODS: Using the American College of Surgeons National @entity1 Database, 16,128 @entity0 underwent gastrectomy for @entity1 from 2003 to 2012. Treatment groups were categorized as NAC or no NAC (ie, adjuvant chemotherapy and surgery only). Univariate and multivariate analyses were performed to estimate trends in utilization and impact of treatment on perioperative outcomes. RESULTS: Of @entity0 undergoing gastrectomy, 36.6% received NAC and 63.4% did not receive chemotherapy in the neoadjuvant setting. @entity0 who received NAC were more frequently younger, male, white, privately insured, with fewer comorbidities, and treated at an @entity4 center (all P  <  .0001). After  controlling for demographics, comorbidities, and @entity1 -related factors, @entity0 who received NAC had a postoperative duration of stay 0.43  days shorter than @entity0 who did not receive chemotherapy (5.79 vs 6.22  days; P  =  .050). They had a 36% lower odds of 30-day mortality (odds ratio, 0.64, P  <  .0001) but nonsignificant lower odds of 90-day mortality. Use of NAC increased annually, with the greatest increases seen in @entity4 facilities and in the Northeast and North Central United States. CONCLUSION: With concerns regarding the @entity2 of NAC, these findings suggest that NAC is not associated with worse postoperative outcomes. In light of evidence touting the benefits of NAC, its adoption as a component in the multimodality care of @entity3 is slowly increasing, although use of NAC remains poor overall.

title: Trends in the use and impact of neoadjuvant chemotherapy on perioperative outcomes for resected XXXX : Evidence from the American College of Surgeons National @entity1 Database.

answer: @entity3


abstract: BACKGROUND: Standard of care for @entity0 with advanced @entity3 includes administration of neoadjuvant chemotherapy (NAC) before resection. This study assesses the pattern of use and impact of NAC on perioperative outcomes in US medical centers. METHODS: Using the American College of Surgeons National @entity1 Database, 16,128 @entity0 underwent gastrectomy for @entity1 from 2003 to 2012. Treatment groups were categorized as NAC or no NAC (ie, adjuvant chemotherapy and surgery only). Univariate and multivariate analyses were performed to estimate trends in utilization and impact of treatment on perioperative outcomes. RESULTS: Of @entity0 undergoing gastrectomy, 36.6% received NAC and 63.4% did not receive chemotherapy in the neoadjuvant setting. @entity0 who received NAC were more frequently younger, male, white, privately insured, with fewer comorbidities, and treated at an @entity4 center (all P  <  .0001). After  controlling for demographics, comorbidities, and @entity1 -related factors, @entity0 who received NAC had a postoperative duration of stay 0.43  days shorter than @entity0 who did not receive chemotherapy (5.79 vs 6.22  days; P  =  .050). They had a 36% lower odds of 30-day mortality (odds ratio, 0.64, P  <  .0001) but nonsignificant lower odds of 90-day mortality. Use of NAC increased annually, with the greatest increases seen in @entity4 facilities and in the Northeast and North Central United States. CONCLUSION: With concerns regarding the @entity2 of NAC, these findings suggest that NAC is not associated with worse postoperative outcomes. In light of evidence touting the benefits of NAC, its adoption as a component in the multimodality care of @entity3 is slowly increasing, although use of NAC remains poor overall.

title: Trends in the use and impact of neoadjuvant chemotherapy on perioperative outcomes for resected @entity3 : Evidence from the American College of Surgeons National XXXX Database.

answer: @entity1


abstract: BACKGROUND: Autoantibodies against monomeric @entity4 (anti-CRP-Ab) observed in @entity0 with @entity3 ( @entity3 ) and @entity5 ( @entity5 ) were suggested to be associated with active @entity5 and a poor response to therapy during short-term follow-up. The aim of this study was to confirm this finding and to investigate the prognostic value of anti-CRP-Ab in @entity0 with @entity5 during long-term follow-up. METHODS: Sera of 57 @entity3 @entity0 (47 @entity0 , 10 @entity0 ) with biopsy proven @entity5 and 122 healthy individuals were analyzed for the presence of anti-CRP-Ab by in-house ELISA. Anti-CRP-Ab levels were studied in relation to routine laboratory tests, urine analysis, levels of C3, C4, other immunological markers and the overall disease activity as assessed by @entity3 ( @entity3 ). The prognostic value of anti-CRP-Ab was tested in a subgroup of 29 newly diagnosed @entity5 @entity0 (median follow-up 5.9  years). Response to therapy at various time points was assessed with respect to baseline anti-CRP-Ab levels. At least partial response in the first/second  year of treatment was considered as a "favorable outcome", while non-response, renal flare or end @entity2 were considered as "unfavorable outcome". RESULTS: Anti-CRP-Ab were only detected in @entity0 with @entity1 and their levels correlated with @entity3 (rs   =   0.165, p   =   0.002). The time to response was shorter in patients being anti-CRP-Ab negative at baseline compared to anti-CRP-Ab positive @entity0 , p   =   0.037. In the second year of therapy, baseline anti-CRP-Ab positivity was a significant predictor of "unfavorable outcome" (OR [95  % CI]   =   15.6 [1.2-771]; p   =   0.021). The predictive value of "baseline anti-CRP positivity" further increased when combined with "non-response to therapy in the first year". Baseline anti-CRP-Ab positivity was not a predictor of "unfavorable outcome" at the end of follow-up, (OR [95  % CI]   =   5.5 [0.6-71.1], p   =   0.169). CONCLUSIONS: Baseline serum levels of anti-CRP-Ab seem to be a strong risk factor for a composite outcome of non-response, renal flare or end @entity2 after two years of standard treatment of @entity5 . The response to therapy seems to be delayed in anti-CRP-Ab positive @entity0 .

title: Prognostic value of anti-CRP antibodies in XXXX in long-term follow-up.

answer: @entity5


abstract: BACKGROUND: @entity0 diagnosed with @entity1 ( @entity1 ) are presented with several treatment options of similar efficacy but varying side effects. Understanding how and why @entity0 make their treatment decisions, as well as the effect of treatment choice on long-term outcomes, is critical to ensuring effective, @entity0 -centered care. This study examined treatment decision-making in a racially diverse, equal-access, contemporary cohort of @entity0 with @entity1 counseled on treatment options at a multidisciplinary clinic. METHODS: A prospective cohort study was initiated at the Walter Reed National Military Medical Center (formerly Walter Reed Army Medical Center) in 2006. Newly diagnosed @entity0 with @entity1 were enrolled before attending a multidisciplinary clinic. @entity0 completed surveys preclinic and postclinic to assess treatment preferences, reasons for treatment choice, and decisional regret. RESULTS: As of January 2014, 925 @entity0 with @entity1 enrolled in this study. Surgery (54%), external radiation (20%), and active surveillance (12%) were the most common primary treatments for @entity0 with low- and intermediate-risk @entity1 , whereas @entity0 with high-risk @entity1 chose surgery (34%) or external radiation with neoadjuvant hormones (57%). Treatment choice differed by age at diagnosis, race, comorbidity status, and calendar year in both univariable and multivariable analyses. @entity0 preferred to play an active role in the decision-making process and cited doctors at the clinic as the most helpful source of treatment-related information. Almost all @entity0 reported satisfaction with their decision. CONCLUSIONS: This is one of the first prospective cohort studies to examine treatment decision-making in an equal-access, multidisciplinary clinic setting. Studies of this cohort would aid in understanding and improving the @entity1 decision-making process.

title: A prospective cohort study of treatment decision-making for XXXX following participation in a multidisciplinary clinic.

answer: @entity1


abstract: Metastatic @entity0 is currently incurable despite initial responsiveness, assumingly due to the presence of chemoresistant subpopulations that can be characterized as label retaining cells (LRC). In the 4T1 @entity3 @entity0 model, we previously achieved cure after @entity5 and Total Body Irradiation (CY + TBI) followed by haploidentical bone marrow and spleen transplantation (BMSPLT). CY + TBI without transplantation induced only transient @entity2 growth indicating a critical role of donor immune cells. As it remained unknown if the 4T1 model resembles @entity1 disease with respect to the presence of subpopulations of chemoresistant LRC, we now demonstrate this is indeed the case. Chemoresistance of 4T1 LRC was demonstrated by in vitro co-incubation of fluorescently labeled 4T1 cells in limiting dilution with @entity5 , @entity4 or @entity6 , after which only LRC containing colonies remained. LRC also remain in vivo after treatment with CY + TBI. Succeeding experiments set up to identify the haploidentical effector cell responsible for cure and, therefore, for the elimination of chemoresistant LRC designate donor NK cells crucial for the anti- @entity2 effect. NK cell depletion of the haploidentical graft fully abrogated the anti- @entity2 effect. Increased disease-free survival retained after transplantation of haploidentical bone marrow and NK cell-enriched spleen cell grafts, even in the absence of donor T-cells or of donor bone marrow. Tumor growth analysis indicates the anti- @entity2 effect being immediate (days). Based on these data, it is worthwhile to explore alloreactive adoptive NK cell therapy as consolidation for @entity1 with metastasized @entity0 .

title: Elimination of the chemotherapy resistant subpopulation of 4T1 @entity3 XXXX by haploidentical NK cells cures the vast majority of @entity3 .

answer: @entity0


abstract: Metastatic @entity0 is currently incurable despite initial responsiveness, assumingly due to the presence of chemoresistant subpopulations that can be characterized as label retaining cells (LRC). In the 4T1 @entity3 @entity0 model, we previously achieved cure after @entity5 and Total Body Irradiation (CY + TBI) followed by haploidentical bone marrow and spleen transplantation (BMSPLT). CY + TBI without transplantation induced only transient @entity2 growth indicating a critical role of donor immune cells. As it remained unknown if the 4T1 model resembles @entity1 disease with respect to the presence of subpopulations of chemoresistant LRC, we now demonstrate this is indeed the case. Chemoresistance of 4T1 LRC was demonstrated by in vitro co-incubation of fluorescently labeled 4T1 cells in limiting dilution with @entity5 , @entity4 or @entity6 , after which only LRC containing colonies remained. LRC also remain in vivo after treatment with CY + TBI. Succeeding experiments set up to identify the haploidentical effector cell responsible for cure and, therefore, for the elimination of chemoresistant LRC designate donor NK cells crucial for the anti- @entity2 effect. NK cell depletion of the haploidentical graft fully abrogated the anti- @entity2 effect. Increased disease-free survival retained after transplantation of haploidentical bone marrow and NK cell-enriched spleen cell grafts, even in the absence of donor T-cells or of donor bone marrow. Tumor growth analysis indicates the anti- @entity2 effect being immediate (days). Based on these data, it is worthwhile to explore alloreactive adoptive NK cell therapy as consolidation for @entity1 with metastasized @entity0 .

title: Elimination of the chemotherapy resistant subpopulation of 4T1 XXXX @entity0 by haploidentical NK cells cures the vast majority of @entity3 .

answer: @entity3


abstract: Metastatic @entity0 is currently incurable despite initial responsiveness, assumingly due to the presence of chemoresistant subpopulations that can be characterized as label retaining cells (LRC). In the 4T1 @entity3 @entity0 model, we previously achieved cure after @entity5 and Total Body Irradiation (CY + TBI) followed by haploidentical bone marrow and spleen transplantation (BMSPLT). CY + TBI without transplantation induced only transient @entity2 growth indicating a critical role of donor immune cells. As it remained unknown if the 4T1 model resembles @entity1 disease with respect to the presence of subpopulations of chemoresistant LRC, we now demonstrate this is indeed the case. Chemoresistance of 4T1 LRC was demonstrated by in vitro co-incubation of fluorescently labeled 4T1 cells in limiting dilution with @entity5 , @entity4 or @entity6 , after which only LRC containing colonies remained. LRC also remain in vivo after treatment with CY + TBI. Succeeding experiments set up to identify the haploidentical effector cell responsible for cure and, therefore, for the elimination of chemoresistant LRC designate donor NK cells crucial for the anti- @entity2 effect. NK cell depletion of the haploidentical graft fully abrogated the anti- @entity2 effect. Increased disease-free survival retained after transplantation of haploidentical bone marrow and NK cell-enriched spleen cell grafts, even in the absence of donor T-cells or of donor bone marrow. Tumor growth analysis indicates the anti- @entity2 effect being immediate (days). Based on these data, it is worthwhile to explore alloreactive adoptive NK cell therapy as consolidation for @entity1 with metastasized @entity0 .

title: Elimination of the chemotherapy resistant subpopulation of 4T1 @entity3 @entity0 by haploidentical NK cells cures the vast majority of XXXX .

answer: @entity3


abstract: @entity1 may result in delay of language development. There is on the one hand a large group of @entity0 with bilateral @entity6 , most of whom will be amenable to appropriate treatment, and on the other a group, possibly more numerous, who have a variety of disorders of speech and language, varying from lack of speech associated with severe @entity4 to more specific defects, such as @entity8 and @entity5 . These disorders are probably due to a defect of cerebral function at the highest level and in these @entity0 no-one will have suspected @entity7 or have suggested that there is an abnormal response to auditory stimuli. Some @entity0 will start life with such an abnormal response but as they grow older will cease to show the characteristics of @entity7 . This group is analysed and it is suggested that some may be diagnosed as suffering from @entity7 . The E. E. G./Audiogram is useful in the differenciation of these @entity0 from those with @entity7 , especially at an early age when co-operation is limited, or when these are severe @entity2 or infantile @entity3 . This technique will be briefly discusses. @entity0 with @entity7 may be included among those with disorders of language development, but it is possible that this disability may sometimes result from a failure of integration at a cortical level. The reason for suggesting this diagnostic category is to stress that these @entity0 do initially behave in a similar way to those who are perpherally deaf.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Disorders of language development, with particular reference to XXXX .

answer: @entity7


abstract: OBJECTIVE: Determination of the prevalence of @entity4 and its association with signs and symptoms of the hips and knees in a Dutch general population aged 55 years and over. DESIGN: Cross-sectional population-based study. SETTING: Rotterdam-Ommoord, the Netherlands. METHOD: During home interviews of 1,901 @entity0 and 3,132 @entity0 aged 55 years and over living in the Ommoord district of @entity4 was assessed using the Health Assessment Questionnaire (HAQ). Morning @entity5 and @entity2 during the past month were assessed. At the research centre weightbearing radiographs of the hips and knees were taken. @entity3 was defined as Kellgren score 2 or more. A complete physical examination of the hips and knees was performed. RESULTS: The prevalence of @entity4 was 21.9% for independently living @entity0 and 36.0% for independently living @entity0 . In homes for the elderly these figures were 84.0% en 96.5%, respectively. There were significantly elevated age-adjusted odds ratios for @entity4 for @entity0 , @entity0 in homes for the elderly, independently living @entity0 with only primary education, independently living @entity0 with a below-median net annual income and widowed @entity0 in homes for the elderly. Taking the associations between the independent variables into account only morning @entity5 , @entity2 and restricted flexion of the hips and knees were independently associated with @entity4 in @entity0 . In @entity0 radiological @entity3 of the hips and knees, restricted endorotation of the hip, instability and @entity1 of the knees were also associated with disability. CONCLUSION: The prevalence of @entity4 in @entity0 aged 55 years and over in the general population was high and associated with female sex, low education, low income and living in a home for the elderly. Of the signs and symptoms of the hips and knees only @entity2 , morning @entity5 and restricted flexion of the hip were independently associated with @entity4 . @entity3 of the hip and knee did not contribute much to the explanation of @entity4 .

title: [ XXXX in the elderly; the ERGO Study (Erasmus Rotterdam Health and the Elderly). ERGO Study Group].

answer: @entity4


abstract: A case of recurrent @entity2 ( @entity2 ) was reported. A 46-year-old male underwent total removal of mural nodule from @entity0 in the left temporal lobe in 1986. Histological diagnosis was @entity1 . There were no abnormal neurological signs or symptoms after the operation. However, 6 years after the operation he complained of strong unpleasant smell as of rotten onions and was admitted to our hospital. MRI revealed a @entity0 with a mural nodule which was enhanced markedly by @entity3 in the same location as previous @entity0 site. He was operated upon again and @entity0 was removed with the cyst wall. Histological diagnosis was @entity2 . Surgical procedures for removal of cystic @entity2 has been controversial; @entity0 only, @entity0 removal with biopsy of cyst wall, or @entity0 removal with resection of cyst wall. Real reason for recurrence of this @entity0 in our case is unknown. However, since @entity1 cells were found in the biopsy specimen of the cyst wall at time of the first operation, the @entity0 might have recurred from these cells. Therefore, this time we removed not only the mural nodule but also the cyst wall, because the cyst wall peeled off easily. We would like to propose that @entity2 cyst walls should be resected, whenever possible, in order to accomplish total @entity0 .

title: [Recurrence of XXXX six years after total removal of mural nodule: a case report].

answer: @entity2


abstract: PURPOSE: @entity3 ( @entity3 ) are common symptoms in @entity0 with @entity2 that may interfere with nutritional intake and quality of life. In this study, we explore and describe how characteristics of self-reported @entity3 change in individuals with @entity1 over time using a multiple case study approach to present longitudinal data from individuals. METHODS: @entity0 under investigation for @entity1 were recruited from one university hospital in Sweden. The 52 @entity0 providing data eligible for the analyses presented here were those treated for primary @entity1 with three measurement time-points, of which one was prior to treatment and two after treatment start. Four self-report instruments were used for data collection. These included the Taste and Smell Survey, used to characterize @entity3 for each individual at the three time-points and instruments measuring nutritional status, symptom burden and well-being. Three @entity0 cases are described in detail to illustrate variation in individual experiences of @entity3 . RESULTS: The characteristics of the @entity3 experienced changed over time for many of the individuals in this study, including those undergoing surgery or stereotactic radiotherapy. The case descriptions show how the individual experiences of @entity3 and the impact on daily life of these symptoms not only depend on @entity4 characteristics, but may be influenced by contextual factors, e.g. other symptoms and life situation. CONCLUSIONS: Our results suggest that healthcare professionals need to consider the variation in characteristics of @entity3 among and within @entity0 over time, and be attentive to individual experiences of @entity3 .

title: A longitudinal study of changing characteristics of self-reported taste and smell alterations in @entity0 treated for XXXX .

answer: @entity1


abstract: PURPOSE: @entity3 ( @entity3 ) are common symptoms in @entity0 with @entity2 that may interfere with nutritional intake and quality of life. In this study, we explore and describe how characteristics of self-reported @entity3 change in individuals with @entity1 over time using a multiple case study approach to present longitudinal data from individuals. METHODS: @entity0 under investigation for @entity1 were recruited from one university hospital in Sweden. The 52 @entity0 providing data eligible for the analyses presented here were those treated for primary @entity1 with three measurement time-points, of which one was prior to treatment and two after treatment start. Four self-report instruments were used for data collection. These included the Taste and Smell Survey, used to characterize @entity3 for each individual at the three time-points and instruments measuring nutritional status, symptom burden and well-being. Three @entity0 cases are described in detail to illustrate variation in individual experiences of @entity3 . RESULTS: The characteristics of the @entity3 experienced changed over time for many of the individuals in this study, including those undergoing surgery or stereotactic radiotherapy. The case descriptions show how the individual experiences of @entity3 and the impact on daily life of these symptoms not only depend on @entity4 characteristics, but may be influenced by contextual factors, e.g. other symptoms and life situation. CONCLUSIONS: Our results suggest that healthcare professionals need to consider the variation in characteristics of @entity3 among and within @entity0 over time, and be attentive to individual experiences of @entity3 .

title: A longitudinal study of changing characteristics of self-reported taste and smell alterations in XXXX treated for @entity1 .

answer: @entity0


abstract: A new transtelephonic monitoring device designed for use with @entity1 ( @entity1 ) was evaluated. It is capable of interrogating @entity1 and transmitting the following data via telephone: programmed parameters (e.g., @entity5 [ @entity5 ] and @entity7 [ @entity7 ] detection, therapies), number of @entity5 and @entity7 episodes, identification of successful therapies, the 20 cycle lengths preceding the last episode detected, the 10 cycle lengths after the last delivered therapy, battery voltage, and real-time transmission of the @entity0 's rhythm. Eighteen @entity0 (mean age 64 +/- 17 years; 15 males) were implanted with an @entity6 and epicardial lead system. The @entity0 who did not live near the primary hospital were provided with this transmitter and instructed to transmit monthly and whenever @entity4 , @entity4 , or a shock were experienced. Five hundred ten episodes of spontaneous @entity2 (495 @entity5 , 15 @entity7 ) were detected in 14 of 18 @entity0 in a 24-month period and the success of each therapy (antitachycardia pacing, cardioversion 0.4-34 J, defibrillation 34 J) was analyzed. The number of therapies delivered and their success (%) in terminating the @entity2 were: 380 ramp/86%, 116 burst/84%, 119 cardioversion/57%, and 15 defibrillations/100%. Sixty-three (42%) of the 152 transmissions indicated an @entity2 . Twenty-five (16%) of the 152 were transmitted because of symptoms. Sixteen (9.7%) of 165 @entity5 episodes could not be terminated by the full set of programmed @entity5 therapies. Analysis of the pre- and post-episode intervals along with the @entity0 's transmitted rhythm indicated that @entity8 or @entity3 were likely responsible for these episodes.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Transtelephonic monitoring and transmission of stored XXXX detection and therapy data from an implantable cardioverter defibrillator.

answer: @entity2


abstract: The aim of the study has to be find, on basis of long term follow-up, an independent factors determining of pacemaker implantation in @entity0 with @entity6 . The second point was to find an independent risk factors of @entity2 and another serious complication in this group of @entity0 (specially in paced group). The study group consisted 169 pts with @entity6 (in all pts abnormal electrophysiological tests--transoesophageal atrial stimulation). The form of @entity6 (extrinsic or intrinsic) was determined on basis of electrophysiological study after pharmacological denervation of the heart ( @entity5 and @entity7 i.v. in doses 0.2 and 0.04 mg/kg body weight respectively). The statistical analysis was performed on all pts (97 @entity0 and 72 @entity0 48 +/- 16 yrs old) using Cox's model of proportional hazardous analysing. The follow-up period ranging from 14 to 84 months (mean 49.9 +/- 19). Pacemaker was implanted in 88 pts during observation period. @entity2 signs were found in 7 pts including 6 pts after pacemaker implantation. There was 13 death (7 sudden or primary @entity1 ). CONCLUSIONS: 1) independent factors of pacemaker implantation were @entity3 , age and persistent @entity4 , 2) form of @entity6 was not an independent factor of this decision, 3) age (older), persistent after pacemaker implantation @entity3 and registered in transesophageal ecg ventriculo-atrial condition were independent risk factors of @entity2 in pts with VVI stimulation, 4) despite of pacemaker implantation (VVI mode) many @entity0 have @entity3 or @entity3 attacks but life comfort in this group was much better then before implantation.

title: [ XXXX (extrinsic and intrinsic form) during long term observation].

answer: @entity6


abstract: PURPOSE: This study aimed to evaluate racial/ethnic differences in @entity1 incidence and mortality in the @entity0 's Health Initiative Study, a longitudinal prospective cohort evaluation of postmenopausal @entity0 recruited from 40 clinical centers. METHODS: @entity1 diagnoses were centrally adjudicated by pathology review. Baseline survey questionnaires collected sociodemographic and health information. Logistic regression models estimated incidence and mortality odds by race/ethnicity adjusted for age, education, @entity4 / @entity5 , body mass index, smoking (status, age at start, duration, and pack-years), @entity3 , family history, oral contraceptive, hormones, physical activity, and diet. RESULTS: The cohort included 129,951 @entity0 -108,487 (83%) non-Hispanic white (NHW); 10,892 (8%) @entity6 ( @entity6 ); 4,882 (4%) Hispanic; 3,696 (3%) Asian/Pacific Islander (API); 534 (< 1%) American Indian/Alaskan Native; and 1,994 (1%) other. In unadjusted models, Hispanics had 66% lower odds of @entity1 compared with NHW (odds ratio [OR], 0.34; 95% CI, 0.2 to 0.5), followed by API (OR, 0.45; 95% CI, 0.27 to 0.75) and @entity6 (OR, 0.75; 95% CI, 0.59 to 0.95). In fully adjusted multivariable models, the @entity1 risk for Hispanic compared with NHW @entity0 attenuated to the null (OR, 0.59; 95% CI, 0.35 to 0.99). In unadjusted models Hispanic and API @entity0 had decreased risk of @entity2 compared with NHW @entity0 (OR, 0.30 [95% CI, 0.15 to 0.62] and 0.34 [95% CI, 0.16 to 0.75, respectively); however, no racial/ethnic differences were found in risk of @entity1 @entity2 in fully adjusted models. CONCLUSION: Differences in @entity1 incidence and mortality are associated with sociodemographic, clinical, and behavioral factors. These findings suggest modifiable exposures and behaviors may contribute to differences in incidence of and mortality by race/ethnicity for postmenopausal @entity0 . Interventions focused on these factors may reduce racial/ethnic differences in @entity1 incidence and mortality.

title: Racial and Ethnic Variations in Lung Cancer Incidence and Mortality: Results From the XXXX 's Health Initiative.

answer: @entity0


abstract: In 96 cases of @entity4 , results of chronic pharmacological assessment (CPA) were compared with acute electrophysiological-pharmacologic assessments ( @entity3 ) to evaluate the usefulness of @entity3 . I. @entity0 with sustained VT (31 cases): Sustained VT and repetitive ventricular response (RVR) could be induced in 61% and 23% respectively. More than one effective drug was found by @entity3 for 23 of 24 subjects. Of the 22 followed by CPA, the effectiveness of medication was excellent for 14 (64%), moderate for 1, slight for 4, and ineffective for 3 (14%). II. @entity0 with @entity2 (23 cases): RVR could be induced in 52%. Effective medication was identified by @entity3 for 8 of 10 @entity0 . Of the 7 followed by CPA, the effectiveness of medication was excellent for 2(28.5%) moderate for 2, and ineffective for 3. III. @entity0 with PSVT (42 cases): PSVT could be induced in 90% of cases. Effective medication was found for all 31 cases which underwent @entity3 . Of the 23 cases followed by CPA, the chronic efficacy of drugs was excellent for 7 (30%), moderate for 5 (22%), slight for 7 (30%), and noneffective for 4 (18%). Therefore, we conclude that the usefulness of @entity3 differs according to the type of @entity1 . @entity3 is most useful in predicting chronic results for @entity0 with sustained VT, especially when the sustained VT is readily reproducible by electrical stimulation. It is less useful for nonsustained VT and PSVT. With nonsustained VT, @entity3 is limited by difficulty in repeatedly inducing RVR, and by difficulty in predicting the appropriate medication for chronic oral therapy. With PSVT, even though the PSVT can be induced with greater success, @entity3 is limited by variations in pharmacologic effects over time, which create discrepancies between @entity3 and CPA.

title: The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of XXXX .

answer: @entity4


abstract: PRINCIPLES: Therapeutic target serum concentrations of first-line antituberculosis drugs have not been well defined in clinical studies in @entity1 ( @entity1 ) @entity0 . METHODS: We retrospectively investigated the estimated maximum serum concentrations (eCmax) of antituberculosis drugs and clinical outcome of @entity1 @entity0 with therapeutic drug monitoring performed between 2010-2012 at our institution, and follow-up until March 2014. The eCmax was defined as the highest serum concentration during a sampling period (2, 4 and 6 hours after drug ingestion). We compared the results with published eCmax values, and categorised them as either "within reference range", "low eCmax", or "very low eCmax".Low/very low eCmax-levels were defined as follows: @entity3 2-3/<2 mg/l, @entity2 4-8/<4 mg/l, @entity6 0.2-0.3/<0.2 mg/l, @entity4 1-2/<0.1 mg/l and @entity5 <20 mg/l. RESULTS: Concentrations of antituberculosis drugs in 175 serum samples of 17 @entity0 with @entity1 were analysed. In 12 (71%) @entity0 , multiple therapeutic drug monitoring samples were collected over time, in 5 (29%) @entity0 only one sample was available for therapeutic drug monitoring. Overall, 94% of all @entity0 had at least one low antituberculosis drug concentration. Overall, 64% of all eCmax levels were classified as "low" or "very low". The eCmax was below the relelvant reference range in 80% of @entity3 , 95% of @entity2 , 30% of @entity5 , and 30% of @entity4 measurements. All but one @entity0 were cured of @entity1 . CONCLUSIONS: Although many antituberculosis drug serum concentrations were below the widely used reference ranges, 16 of 17 @entity0 were cured of @entity1 . These results challenge the use of the published reference ranges for therapeutic drug monitoring.

title: Cure of XXXX despite serum concentrations of antituberculosis drugs below published reference ranges.

answer: @entity1


abstract: Greater understanding of the underlying pathophysiology of @entity7 ( @entity7 ) has led to more aggressive management and lower mortality, both in-hospital and long term. @entity7 results mainly from @entity8 of the @entity10 -related coronary artery. The ensuing @entity1 evolves over a 6-12 h period providing a time window for interventions designed to reduce eventual @entity10 size. The most appropriate interventions are those which restore coronary artery patency and hence myocardial blood flow as soon as possible. Occasionally, disruption of the occluding thrombus and compression of the underlying @entity3 is best achieved by direct percutaneous transluminal coronary angioplasty. For the vast majority however, revascularisation by drug therapy is more appropriate. As soon as possible, all @entity0 without contraindications should be offered oral @entity5 and intravenous thrombolysis, usually with streptokinase but occasionally with tissue plasminogen activator. @entity0 in whom these agents are contraindicated should be considered for intravenous beta-blockade using @entity13 or @entity12 to reduce myocardial demand and hence @entity10 size. @entity0 with large @entity10 , @entity2 , @entity9 or @entity4 should be considered for early @entity11 inhibitor therapy. Other agents may be valuable symptomatically, but have no proven role in reducing @entity10 size or mortality. After the first 24 h, the main aims of management are to assess the likelihood of later ischaemic events or @entity6 (risk stratification) and hence to choose appropriate long term secondary prophylaxis.

title: The management of XXXX .

answer: @entity7


abstract: UNASSIGNED: On September 30th, 2014, the Centers for Disease Control and Prevention (CDC) confirmed the first travel-associated case of US Ebola in Dallas, TX. This case exposed two of the greatest concerns in @entity0 safety in the US outpatient health care system: misdiagnosis and ineffective use of electronic health records (EHRs). The case received widespread media attention highlighting failures in disaster management, @entity1 control, national security, and @entity2 ( @entity2 ) care. In addition, an error in making a correct and timely Ebola diagnosis on initial @entity2 presentation brought diagnostic decision-making vulnerabilities in the EHR era into the public eye. In this paper, we use this defining "teachable moment" to highlight the public health challenge of diagnostic errors and discuss the effective use of EHRs in the diagnostic process. We analyze the case to discuss several missed opportunities and outline key challenges and opportunities facing diagnostic decision-making in EHR-enabled health care. It is important to recognize the reality that EHRs suffer from major usability and inter-operability issues, but also to acknowledge that they are only tools and not a replacement for basic history-taking, examination skills, and critical thinking. While physicians and health care organizations ultimately need to own the responsibility for addressing diagnostic errors, several national-level initiatives can help, including working with software developers to improve EHR usability. Multifaceted approaches that account for both technical and non-technical factors will be needed. Ebola US @entity0 Zero reminds us that in certain cases, a single misdiagnosis can have widespread and costly implications for public health.

title: Ebola US XXXX Zero: lessons on misdiagnosis and effective use of electronic health records.

answer: @entity0


abstract: OBJECTIVE: We previously reported the interim effects in a per protocol analysis of a randomized controlled trial of an innovative neuroscience-informed computerized cognitive training approach in @entity2 . Here we report the effects of training on behavioral outcome measures in our final sample using an intent-to-treat analysis. We also report the effects on serum @entity4 ( @entity4 ). METHOD: Eighty-seven clinically stable @entity0 with @entity2 were randomly assigned to either targeted @entity3 ( @entity3 , N=46) or a computer games control condition (CG, N=41). @entity0 were assessed on neurocognition, symptoms and functional outcome at baseline and after 50 hours of intervention delivered over 10 weeks. Serum @entity4 was assessed at baseline, at 2 weeks, and at 10 weeks. RESULTS: After the intervention, @entity3 @entity0 showed significant @entity1 , speed of processing, verbal learning, and verbal memory, relative to CG @entity0 , with no changes in symptoms or functioning. At baseline, @entity2 @entity0 had significantly lower-than-normal serum @entity4 . @entity3 @entity0 showed a significant increase in serum @entity4 compared to CG @entity0 , and "normalized" levels by post training. CONCLUSIONS: @entity0 with chronic @entity2 made significant @entity1 after 50 hours of intensive computerized training delivered as a stand-alone treatment, but no improvement in symptoms or functioning. Serum @entity4 levels were significantly increased, and may serve as a peripheral biomarker for the effects of training. Future research must focus on: 1) Methods of integrating cognitive training with psychosocial treatments; 2) A deeper understanding of underlying neurophysiology in order to enhance critical mechanisms of action.

title: Neuroscience-informed Auditory Training in XXXX : A Final Report of the Effects on Cognition and Serum @entity4 .

answer: @entity2


abstract: OBJECTIVE: We previously reported the interim effects in a per protocol analysis of a randomized controlled trial of an innovative neuroscience-informed computerized cognitive training approach in @entity2 . Here we report the effects of training on behavioral outcome measures in our final sample using an intent-to-treat analysis. We also report the effects on serum @entity4 ( @entity4 ). METHOD: Eighty-seven clinically stable @entity0 with @entity2 were randomly assigned to either targeted @entity3 ( @entity3 , N=46) or a computer games control condition (CG, N=41). @entity0 were assessed on neurocognition, symptoms and functional outcome at baseline and after 50 hours of intervention delivered over 10 weeks. Serum @entity4 was assessed at baseline, at 2 weeks, and at 10 weeks. RESULTS: After the intervention, @entity3 @entity0 showed significant @entity1 , speed of processing, verbal learning, and verbal memory, relative to CG @entity0 , with no changes in symptoms or functioning. At baseline, @entity2 @entity0 had significantly lower-than-normal serum @entity4 . @entity3 @entity0 showed a significant increase in serum @entity4 compared to CG @entity0 , and "normalized" levels by post training. CONCLUSIONS: @entity0 with chronic @entity2 made significant @entity1 after 50 hours of intensive computerized training delivered as a stand-alone treatment, but no improvement in symptoms or functioning. Serum @entity4 levels were significantly increased, and may serve as a peripheral biomarker for the effects of training. Future research must focus on: 1) Methods of integrating cognitive training with psychosocial treatments; 2) A deeper understanding of underlying neurophysiology in order to enhance critical mechanisms of action.

title: Neuroscience-informed Auditory Training in @entity2 : A Final Report of the Effects on Cognition and Serum XXXX .

answer: @entity4


abstract: AIMS: Among @entity0 undergoing cryoballoon-based @entity3 ( @entity3 ) ablation, in order to reduce access site complications, improve staff ef   ciency, and decrease length of stay, various techniques have been implemented to achieve immediate haemostasis. We aimed to assess the efficacy and safety of 'figure-of-eight (FoE)' suture when compared with conventional manual compression for immediate closure of 15-French (Fr) calibre right femoral venous access after cryoablation. METHODS AND RESULTS: A total of 200 @entity0 (48% female, mean age 55    12.4 years, and 77% paroxysmal @entity3 ) with symptomatic @entity3 underwent initial cryoablation procedure. All the patients were anticoagulated with heparin during the procedure. In a sequential allocation, FoE suture (Group 1 = 100) and conventional manual compression (Group 2 = 100) were used in achieving haemostasis at right femoral venous access site following 15 @entity5 . In the FoE suture group, haemostasis was achieved immediately after tying the knot (n = 95) or within  <=1 min of light pressure (n = 4). One @entity0 had failure of the stitch as the silk suture snapped during knotting, and haemostasis was achieved by manual compression as per the usual protocol. The median time to haemostasis was shorter in the suture group (0 vs. 14 min, P < 0.001). On immediate and short-term (3 months) follow-up, there was no evidence of minor or major vascular access site complications like haematoma, re-bleeding, @entity1 formation, or @entity2 at right femoral site in the suture group. CONCLUSION: The 'FoE' suture, as a simple, efficacious and likely safe technique, might be an alternative approach to achieve an immediate haemostasis after removal of 15 Fr right femoral @entity4 in @entity0 undergoing cryoablation.

title: Usefulness of 'figure-of-eight' suture to achieve haemostasis after removal of 15-French calibre femoral XXXX in @entity0 undergoing cryoablation.

answer: @entity4


abstract: AIMS: Among @entity0 undergoing cryoballoon-based @entity3 ( @entity3 ) ablation, in order to reduce access site complications, improve staff ef   ciency, and decrease length of stay, various techniques have been implemented to achieve immediate haemostasis. We aimed to assess the efficacy and safety of 'figure-of-eight (FoE)' suture when compared with conventional manual compression for immediate closure of 15-French (Fr) calibre right femoral venous access after cryoablation. METHODS AND RESULTS: A total of 200 @entity0 (48% female, mean age 55    12.4 years, and 77% paroxysmal @entity3 ) with symptomatic @entity3 underwent initial cryoablation procedure. All the patients were anticoagulated with heparin during the procedure. In a sequential allocation, FoE suture (Group 1 = 100) and conventional manual compression (Group 2 = 100) were used in achieving haemostasis at right femoral venous access site following 15 @entity5 . In the FoE suture group, haemostasis was achieved immediately after tying the knot (n = 95) or within  <=1 min of light pressure (n = 4). One @entity0 had failure of the stitch as the silk suture snapped during knotting, and haemostasis was achieved by manual compression as per the usual protocol. The median time to haemostasis was shorter in the suture group (0 vs. 14 min, P < 0.001). On immediate and short-term (3 months) follow-up, there was no evidence of minor or major vascular access site complications like haematoma, re-bleeding, @entity1 formation, or @entity2 at right femoral site in the suture group. CONCLUSION: The 'FoE' suture, as a simple, efficacious and likely safe technique, might be an alternative approach to achieve an immediate haemostasis after removal of 15 Fr right femoral @entity4 in @entity0 undergoing cryoablation.

title: Usefulness of 'figure-of-eight' suture to achieve haemostasis after removal of 15-French calibre femoral @entity4 in XXXX undergoing cryoablation.

answer: @entity0


abstract: Testicular and sexual function was investigated in 9 @entity0 between 16 and 28 years old with @entity4 . At personal interview all @entity0 claimed to experience normal erections and orgasm but 7 had @entity2 . Examination showed a normally developed male habitus. Orchiopexies had been performed in late childhood or adolescence. Two @entity0 were anorchic and the surviving testicles were small in the remaining 7. Serum @entity1 was low in 1 @entity0 and normal in 6 but at the expense of high luteinizing hormone levels in 4. All @entity0 had a high serum follicle-stimulating hormone level, reflecting the @entity3 found in 5 @entity0 tested. Three biopsies from atypical cases showed poor histological findings but 2 revealed early spermatogenesis. The testes in @entity0 with @entity4 are similar to undescended testes in otherwise normal @entity0 . Late orchiopexy produces sexually active but infertile @entity0 .

title: Testicular and sexual function in adults with XXXX .

answer: @entity4


abstract: @entity3 is rare among adults. Thirty-two @entity0 with cervical @entity1 were treated at the Mayo Clinic between 1950 and 1982. The records of these @entity0 were reviewed to investigate the clinical and pathologic behavior of this lesion in @entity0 more than 16 years of age. The lesions were seen in all decades of adult life and equally in @entity0 and @entity0 . Most lesions presented as a rapidly enlarging, asymptomatic mass. The anterior triangle of the neck was involved nearly as often as the posterior triangle, and right-sided locations predominated (72%). Histopathologic differentiation of the lesions into simplex, cavernous, and @entity2 was not helpful in predicting clinical behavior. Surgical excision is the treatment of choice. The lesions may intimately involve the carotid sheath or adjacent nerves. Recurrence in 21% of the 28 @entity0 on whom follow-up data were available mostly represented incomplete excision. @entity1 should be included in the differential diagnosis of a large asymptomatic neck mass of recent origin in the adult.

title: XXXX in the adult.

answer: @entity3


abstract: INTRODUCTION: There are two main methods to treat @entity2 ( @entity2 ) in @entity3 . The first method is surgical intervention on the side of the @entity1 , and the second involves denervating the depressor muscles on the healthy side. It is sometimes difficult for @entity0 to ethically accept the denervating healthy tissue; therefore, we performed the T-shape double fascia graft (TSDFG), which reportedly restores symmetry. In this study, we report our experience with TSDFG and evaluation of the outcomes including the @entity0 questionnaires. METHODS: Two fascia strips from the thigh, 7  *  70  mm in size, were used; one was grafted horizontally at the lower lip to correct the static position, and the other was grafted obliquely at the lateral side by folding and crossing the horizontal fascia. A total of nine @entity0 were treated by this procedure; three procedures were performed individually and six were performed in combination with another static or reanimation procedure. A questionnaire containing a five-point scoring system for facial appearance in multiple situations and other problems was sent to each @entity0 at least 6 months after the surgery. RESULT: From the physicians' point of view, all @entity0 achieved an improvement in symmetry of the lower lip, particularly when opening of the mouth; however, assessments from the @entity0 demonstrated much less satisfaction. The main reason for the dissatisfaction was the slight bulkiness of the red lip. There was one comment that noted that with more treatment, the expectations were higher, and, as a result, the @entity0 could not admit satisfaction at the end. DISCUSSION: TSDFG is a simple and effective procedure for @entity2 ; however, slight modifications may be required. In addition, there were some gaps in the perception of the results between the physicians and @entity0 , and we need to consider these when planning to treat @entity2 .

title: Assessment of T-shape double fascia graft for lower XXXX from @entity3 : A questionnaire survey.

answer: @entity2


abstract: INTRODUCTION: There are two main methods to treat @entity2 ( @entity2 ) in @entity3 . The first method is surgical intervention on the side of the @entity1 , and the second involves denervating the depressor muscles on the healthy side. It is sometimes difficult for @entity0 to ethically accept the denervating healthy tissue; therefore, we performed the T-shape double fascia graft (TSDFG), which reportedly restores symmetry. In this study, we report our experience with TSDFG and evaluation of the outcomes including the @entity0 questionnaires. METHODS: Two fascia strips from the thigh, 7  *  70  mm in size, were used; one was grafted horizontally at the lower lip to correct the static position, and the other was grafted obliquely at the lateral side by folding and crossing the horizontal fascia. A total of nine @entity0 were treated by this procedure; three procedures were performed individually and six were performed in combination with another static or reanimation procedure. A questionnaire containing a five-point scoring system for facial appearance in multiple situations and other problems was sent to each @entity0 at least 6 months after the surgery. RESULT: From the physicians' point of view, all @entity0 achieved an improvement in symmetry of the lower lip, particularly when opening of the mouth; however, assessments from the @entity0 demonstrated much less satisfaction. The main reason for the dissatisfaction was the slight bulkiness of the red lip. There was one comment that noted that with more treatment, the expectations were higher, and, as a result, the @entity0 could not admit satisfaction at the end. DISCUSSION: TSDFG is a simple and effective procedure for @entity2 ; however, slight modifications may be required. In addition, there were some gaps in the perception of the results between the physicians and @entity0 , and we need to consider these when planning to treat @entity2 .

title: Assessment of T-shape double fascia graft for lower @entity2 from XXXX : A questionnaire survey.

answer: @entity3


abstract: The principal treatment concept in the Utrecht @entity5 Centre is megavoltage irradiation, followed by @entity6 and/or cryotherapy if there is any doubt as to whether the @entity1 is still active. Radiation therapy is administered by means of a simple but highly accurate temporal beam technique. A standardized dose of 45 Gy is given in 15 fractions of 3 Gy at 3 fractions per week. From 1971 to 1982, 39 @entity0 with @entity5 have been irradiated in at least one eye. Of the 73 affected eyes, 18 were primarily enucleated, one received @entity6 only, and 54 received radiation therapy. Of the 54 @entity4 , 32 were additionally treated by @entity6 and/or cryotherapy for suspicious @entity1 (in 29 eyes), recurrent @entity1 (in 3 eyes) and 10 were ultimately enucleated. Two eyes also received @entity2 . The percentages of cure of the @entity4 with a minimum follow-up of 2 years were 100% (14/14), 100% (9/9), 83% (10/12), 79% (11/14) and 0% (0/5) in the Reese-Ellsworth groups I to V-A, respectively. Of the saved eyes 95% achieved useful vision. Eighteen eyes developed a clinically detectable radiation @entity3 ; in five of these the lens was aspirated. Cataracts developed exclusively in those lenses of which a posterior portion of more than 1 mm had to be included in the treatment field. The likelihood and the degree of @entity3 formation was found to be directly related to the dose of radiation to the germinative zone of the lens epithelium. The minimum cataractogenic dose found in this series was 8 Gy.

title: Treatment of XXXX by precision megavoltage radiation therapy.

answer: @entity5


abstract: To evaluate the capability of magnetic resonance (MR) in imaging normal acoustic nerves, 12 volunteers without signs or symptoms of @entity4 were examined using a 0.6 T superconductive system. Several @entity7 ( @entity7 ) pulse sequences were tested to identify the optimal sequence for demonstration of the acoustic nerve bundle. Repetition times (TRs) varied from 300 to 2000 msec and echo times (TEs) from 30 to 120 msec. A single-slice technique was used with 5 and 8 mm sections, one or two data acquisitions per projection, and axial and coronal imaging. The normal acoustic nerves were demonstrated readily by MR in axial and/or coronal sections. The distal parts of the nerves and @entity1 were imaged best with @entity7 1500/60. The @entity5 tended to be obscured in this sequence by brightening the cerebrospinal fluid signal adjacent to the brainstem, but they were demonstrated clearly with 500 or 800 msec TR and 30 msec TE. Five @entity0 were studied who had @entity3 and evidence of @entity8 . In four @entity0 , MR imaging demonstrated five acoustic nerve @entity1 ranging in size from purely intracanalicular to a 12 mm cisternal component. In the fifth case, no @entity1 was identified by MR imaging or gas computed tomographic (CT) cisternography. Contrast-enhanced CT using a Siemens Somatom DR 3 or GE CT/T 8800 scanner failed to provide convincing evidence of @entity1 in any case, while gas CT cisternography was positive in all five @entity1 . All five @entity6 were identified readily using the @entity7 sequences that proved optimal for demonstration of normal nerves. This experience revealed that MR imaging can demonstrate the eighth nerve complex well and reliably. @entity2 (5 or 8 mm) technique is adequate, but multislice without tissue gaps (used recently) is more efficient. Small, even intracanalicular, @entity6 are imaged effectively, indicating that the method is capable of superseding contrast CT cisternography, particularly with improving technology.

title: MR imaging of the acoustic nerves and small XXXX at 0.6 T: prospective study.

answer: @entity6


abstract: A series of 215 @entity0 with @entity2 localized to the pelvis received radical radiotherapy. Treatment results have been correlated with the @entity1 stage, @entity1 size defined independently from stage, doses of radiation and histological grade. The following ranges from 2 to 13 years (median 5 years). Local recurrence was observed in 6.6 percent of stage B, 16.1 per cent of stage C and 20 per cent of stage D1 cases. Eighty per cent of the @entity0 with stage B disease, 56 per cent with stage C and 0 per cent with stage D1 survived 5 years free of disease. Tumors less than 2 cm. in diameter were controlled uniformly, while @entity1 more than 2 cm. in diameter showed an over-all local control rate of about 85 per cent. Increasing size resulted in a higher incidence of distant metastases. A dose of 6,500 rad (180 to 200 rad per day) appears adequate for @entity1 less than 2 cm. in diameter and stage B @entity1 , while higher stage @entity1 require doses of 7,000 rad (180 to 200 rad per day). Most high grade @entity1 and massive @entity1 of any grade fail outside the pelvis.

title: Prognostic parameters in radiotherapeutic management of localized XXXX .

answer: @entity2


abstract: We determined the details of ventricular activation sequence during the onset of @entity2 in 6 @entity0 . Unipolar electrograms were simultaneously recorded from 192 ventricular epicardial sites evenly spaced in a 3 by 3 cm square area surrounding 2 central sites to which stimuli for inducing @entity1 were delivered. In 5 @entity0 , 2 to 10 msec duration pulses with amplitudes of 150 to 220 v were used to induce @entity1 , and in 1 @entity0 , 3 successive permature stimuli of 3 v intensity were used to induce @entity1 . In 2 @entity0 the pattern of activation at the onset of @entity1 was compatible with local reentrant paths near the stimulus site. Fibrillation was induced with a single high intensity pulse in both of these @entity0 . In the other 4 @entity0 , the pattern of activation at the onset of @entity1 was highly suggestive of reentrant paths distant from the stimulating electrodes. In 3 of these @entity0 @entity1 was induced by a single high intensity pulse and in the other it was induced by 3 repetitive stimuli. Activation patterns resembling supraventricular activation occurred prior to @entity1 in the latter animal. The data demonstrate 2 distinct modes of onset of electrically induced @entity2 . The findings support local reentry in the region of the stimulus site as the mode of onset of @entity1 in some animals and possible reentry at sites distant from the stimulus site with participation of the specialized conduction system in other animals. The differences in mode of onset of electrically induced @entity1 may be responsible for instability of @entity1 threshold measurements in some animals. In addition the role of the specialized conduction system in the onset of @entity1 may be responsible for the effects of sympathetic and vagal stimulation on @entity1 threshold.

title: Detailed activation sequence in the region of electrically induced XXXX in @entity0 .

answer: @entity2


abstract: We determined the details of ventricular activation sequence during the onset of @entity2 in 6 @entity0 . Unipolar electrograms were simultaneously recorded from 192 ventricular epicardial sites evenly spaced in a 3 by 3 cm square area surrounding 2 central sites to which stimuli for inducing @entity1 were delivered. In 5 @entity0 , 2 to 10 msec duration pulses with amplitudes of 150 to 220 v were used to induce @entity1 , and in 1 @entity0 , 3 successive permature stimuli of 3 v intensity were used to induce @entity1 . In 2 @entity0 the pattern of activation at the onset of @entity1 was compatible with local reentrant paths near the stimulus site. Fibrillation was induced with a single high intensity pulse in both of these @entity0 . In the other 4 @entity0 , the pattern of activation at the onset of @entity1 was highly suggestive of reentrant paths distant from the stimulating electrodes. In 3 of these @entity0 @entity1 was induced by a single high intensity pulse and in the other it was induced by 3 repetitive stimuli. Activation patterns resembling supraventricular activation occurred prior to @entity1 in the latter animal. The data demonstrate 2 distinct modes of onset of electrically induced @entity2 . The findings support local reentry in the region of the stimulus site as the mode of onset of @entity1 in some animals and possible reentry at sites distant from the stimulus site with participation of the specialized conduction system in other animals. The differences in mode of onset of electrically induced @entity1 may be responsible for instability of @entity1 threshold measurements in some animals. In addition the role of the specialized conduction system in the onset of @entity1 may be responsible for the effects of sympathetic and vagal stimulation on @entity1 threshold.

title: Detailed activation sequence in the region of electrically induced @entity2 in XXXX .

answer: @entity0


abstract: The authors report a series of 13 @entity0 , 8 @entity0 and 5 @entity0 , with an average age of 68 years (range 39 to 87 years) presenting with documented @entity1 with anteroseptal extension in 2 cases. These @entity0 developed LBBB (complete in 9 cases, incomplete in 4 cases). This complications occurred in the acute phase in 8 cases and 4 months to 9 years later (average 4,5 years) in the other 5 cases. The block was intermittent in 4 @entity0 and became permanent in all cases. The diagnosis of @entity1 with LBBB was made by vectorcardiography (VCG) in 5 out of the 13 @entity0 (38,4 p. 100) on the criteria suggested by Starr. 3 of the 8 false negative results were directly related to the block which masked the ECG and VCG signs of @entity1 . The VCG signs observed were an upwards displacement of the QRS loop with preservation of the superior orientation of the initial forces (5 cases). Atypical appearances of LBBB were observed in 2 cases with a posterior and right-sided shift of the efferent loop following the anterior and left-sided orientations of the initial forces. The sensitivity of the VCG and ECG is mediocre in @entity1 with LBBB because the block may mask the electrical signs of @entity1 . The specificity of the VCG could not be assessed because of the mode of selection of the @entity0 and the small number of cases.

title: [Vectorcardiography in XXXX associated with left bundle-branch block].

answer: @entity1


abstract: A saccharolytic spirochete that associated and interacted with cellulolytic bacteria was isolated from @entity0 rumen fluid. Isolation was accomplished by means of a procedure involving serial dilution of a sample of rumen fluid into a cellulose-containing agar medium. Clear zones appeared within the medium as a result of cellulose hydrolysis by rumen bacteria. The saccharolytic spirochete and a cellulolytic bacterium later identified as a strain of Bacteroides succinogenes were isolated from the clear zones. The spirochete did not utilize cellulose, but grew in coculture with the cellulotytic bacterium in cellulose-containing media. When cocultured in these media the spirochete used, as fermentable substrates, soluble @entity9 released from cellulose by the cellulolytic bacterium. In cellulose-containing agar medium the spirochete enhanced cellulose breakdown by the @entity15 . Electron microscopy showed that the helical spirochete cells possessed an outer sheath, a protoplasmic cylinder, and two periplasmic fibrils. Under a @entity2 atmosphere, in a reduced medium containing inorganic salts, rumen fluid, @entity1 , and @entity13 , the spirochete grew to a final density of 1.9 X 10(9) cells/ml. @entity11 , @entity3 , and @entity12 were products of the fermentation of @entity1 by growing cells. @entity2 ( @entity8 ), branched @entity17 , @entity4 , @entity6 , @entity10 , @entity14 , @entity7 , and a @entity5 were required for growth of the spirochete. The results of this study indicated that the rumen spirochete represents a new species of @entity16 . It is proposed that the new species be named @entity16 bryantii.

title: XXXX bryantii sp. nov., a rumen spirochete that interacts with cellulolytic bacteria.

answer: @entity16


abstract: In several countries the suicide rate for @entity1 inpatients has increased more than that for admissions and suicides in the general population. This was also the case in our clinic. This hypothesis was tested: today, because of more liberal management, suicides are committed during hospitalization that in an earlier and more restrictive age would have taken place after discharge. All suicides taking place 1960-1979 in the clinic's main catchment area were examined for previous hospitalization. The hypothesis was not supported. Over twenty years neither the suicide cases nor all discharged @entity0 changed significantly in distribution of age, sex, number of previous admissions, duration of hospitalization, or diagnosis. Therefore, none of these variables explain the increase. In both decades, on the other hand, @entity0 that committed suicide during their stay at the clinic had been hospitalized longer; those that committed suicide within three months after discharge had been hospitalized for a shorter time than the sum of discharged @entity0 . Among the suicides that occurred after discharge, the percentage of @entity3 and addicts was higher and the percentage of @entity2 @entity0 was smaller than among all discharged @entity0 . A change in @entity0 management (more time off, more working outside, more open wards) has preceded the increase in suicides; medical staff, however, has doubled over the decades considered here. Rising pressure for resocialization to avoid hospitalism may heighten suicidal behavior. Preventive measures are discussed.

title: [Increasing suicides of XXXX inpatients: reality or artefact? (author's transl)].

answer: @entity1


abstract: To compare abdomonal aortic surgery for aneurysmal ( @entity4 ) vs occlusive (OCC) disease, 50 consecutive cases of elective bifurcation grafts for @entity4 and 50 consecutive cases for OCC disease were analyzed. The mean age of the @entity4 @entity0 was a decade greater than the OCC @entity0 , and they had more associated diseases. Only six @entity4 @entity0 were @entity0 , while @entity0 predominated in the OCC group. Only three @entity4 @entity0 were claudicants and none had @entity1 . About one third of the OCC group had distal disease, and 14 had @entity1 . Operative mortality was 4% (two deaths in each group). The survival of the grafted @entity4 @entity0 was almost equal to normal expectancy. There were no late thromboses of grafts in the @entity4 group, while there were five late failures in the OCC group. The OCC group underwent significantly more frequent reoperative surgery during the follow-up period. The numerous differences in the two population groups apparent in this study provide a basis for questioning the concept that @entity2 are caused by @entity3 .

title: Differences in results for XXXX vs occlusive disease after bifurcation grafts: results of 100 elective grafts.

answer: @entity2


abstract: Very few studies have been described comparing the value of exercise @entity3 and left @entity2 . The authors designed a study comparing these two investigations with conventional exercise stress testing and coronary angiography. The isotopic investigations were carried out within 48 hours of coronary angiography. A total of 143 @entity0 undergoing coronary angiography (35 normal, 108 coronary @entity0 : 36 single vessel, 36 double vessel and 36 @entity1 ) were included in this study. The lesions were located of the @entity8 (77 cases), left circumflex (77 cases) and right coronary arteries (62). The sensitivity and specificity of both radionuclide investigations were evaluated to assess their diagnostic value; the best results were obtained with @entity3 (sensitivity 86 p. 100; specificity 100 p. 100); angioscintigraphy had a sensitivity of 71 p. 100 and specificity of 97 p. 100, and conventional exercise stress testing of 42 p. 100 and 70 p. 100 respectively. The sensitivity seemed to increase with the degree of @entity5 ; although the sensitivity of @entity3 increased progressively, that of angioscintigraphy doubled in cases of @entity5 90 p. 100 ( @entity5 less than 90 p. 100, sensitivity = 37 p. 100; @entity5 greater than 90 p. 100, sensitivity = 73 p. 100). The sensitivity of @entity3 with respect to the severity of the @entity4 was best in cases of @entity7 (sensitivity in cases of RCA @entity5 = 74 p. 100; sensitivity in @entity8 @entity5 = 58 p. 100; sensitivity in left circumflex @entity5 = 43 p. 100). The sensitivity of left @entity2 was @entity8 (RCA @entity5 = 50 p. 100, @entity8 @entity5 = 64 p. 100, left circumflex @entity5 = 36 p. 100). The sensitivity of both investigations was poor in left circumflex @entity6 even when severely diseased. The sensitivity of both investigations was better in diffuse @entity4 : @entity3 ( @entity1 : 72 p. 100, @entity1 : 92 p. 100, @entity1 : 94 p. 100), left @entity2 (61 p. 100, 69 p. 100, and 83 p. 100 respectively). Although the association of these two radioisotopic investigations does not improve diagnostic sensitivity, it does provide more information about the localisation and extension of the @entity4 especially in @entity8 and @entity7 . These results suggest that these investigations are complementary in the evaluation of @entity0 with @entity4 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Exertion isotope tests in coronary insufficiency. Comparison with isotopic ventriculography and XXXX ].

answer: @entity3


abstract: A twice-a-day treatment schedule has been used to manage 57 @entity0 with moderately advanced and advanced @entity2 of the head and neck between March 1978 and July 1981. Fifty @entity0 received radiation therapy alone to the primary site with neck dissection added in 13; seven received preoperative irradiation followed by resection of the @entity1 and clinically positive lymph nodes. A dose of 120 rad was delivered twice daily to the primary site and upper neck nodes with a 4- to 6-hour interval. The dose from external beam was usually 7440 to 7680 rad for irradiation alone to the primary site. An interstitial implant boost of 1000 to 1500 rad was added in four @entity0 . When at least 7440 was used, 2 of 3 and 11 of 13 T3 lesions were locally controlled with a 2- to 5-year follow-up. T4 lesions were initially treated with 7440 rad, but only one of ten lesions was controlled; the dose was then increased to 7680 to 8100 rad, with or without an implant, and three of eight T4 lesions were controlled. The acute effects were tolerable, and similar to those seen with once-a-day treatments. There has been one possible severe complication of irradiation and two severe complications of salvage operations. The late normal tissue effects of radiation are probably reduced, but the number of @entity0 observed for 4 and 5 years is limited. Determinate survival free of disease at 2 years for the entire group is 47%. The 2-year determinate disease-free survival for Stage III was 86% (6/7), for Stage IVA, 63% (12/19), and for Stage IVB, 22% (5/23).

title: Twice-a-day irradiation technique for XXXX of the head and neck.

answer: @entity2


abstract: The treatment philosophy of anal canal @entity2 is changing. Abdominoperineal resection (APR) with a permanent colostomy is beginning to be replaced by lesser surgical techniques, such as excisional biopsy in a multimodality approach. Radical radiation therapy is capable of eradicating the @entity1 and yielding a high survival rate. External radiation therapy alone has been reported to result in 80% local control and 79% 5-year actuarial survival. Combining external radiation therapy with brachytherapy has yielded a 65% 5-year disease-free survival. Combined chemotherapy and radiation therapy, i.e., preoperative @entity4 and @entity3 , with 3000 rad pelvic irradiation, allowed over 50% of the @entity0 in each of two previous studies to be spared an APR. Close examination of the data shows that APR may not have been necessary in those who had it. Frequently, no disease was found in the resected specimen. When disease was present, there was a high rate of local recurrence in spite of APR. Although the ideal treatment may not be devised, @entity0 are beginning to be cured of this disease while still retaining a functional anal sphincter.

title: Treatment of anal canal XXXX .

answer: @entity2


abstract: The levels of @entity4 ( @entity6 , @entity8 and @entity7 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity3 grown in the lungs of DBA/2 @entity2 . @entity5 levels and the numbers of @entity1 -cell colonies in the lungs were determined at weekly intervals. @entity6 levels in both erythrocytes and plasma significantly increased 1 week after @entity1 inoculation. Three weeks after inoculation, however, @entity6 levels in the erythrocytes showed a greater increase than those in plasma. @entity8 and @entity7 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity8 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4 released into the circulation.This finding was subsequently applied to @entity0 studies. Fifty-two untreated @entity0 with solid @entity1 were examined in the preoperative period. All erythrocyte @entity5 levels from @entity0 were significantly higher than those from control subjects. Plasma @entity8 levels in @entity0 were significantly higher than those in controls, whereas plasma @entity6 and @entity7 levels showed no significant increase. The frequency of raised levels of @entity6 , @entity8 and @entity7 in erythrocytes was significantly greater than in plasma. These results suggest that @entity5 levels in erythrocytes may provide useful information for the detection of @entity1 .

title: Raised @entity4 in erythrocytes from XXXX -bearing @entity2 and @entity0 with solid @entity1 .

answer: @entity3


abstract: The levels of @entity4 ( @entity6 , @entity8 and @entity7 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity3 grown in the lungs of DBA/2 @entity2 . @entity5 levels and the numbers of @entity1 -cell colonies in the lungs were determined at weekly intervals. @entity6 levels in both erythrocytes and plasma significantly increased 1 week after @entity1 inoculation. Three weeks after inoculation, however, @entity6 levels in the erythrocytes showed a greater increase than those in plasma. @entity8 and @entity7 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity8 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4 released into the circulation.This finding was subsequently applied to @entity0 studies. Fifty-two untreated @entity0 with solid @entity1 were examined in the preoperative period. All erythrocyte @entity5 levels from @entity0 were significantly higher than those from control subjects. Plasma @entity8 levels in @entity0 were significantly higher than those in controls, whereas plasma @entity6 and @entity7 levels showed no significant increase. The frequency of raised levels of @entity6 , @entity8 and @entity7 in erythrocytes was significantly greater than in plasma. These results suggest that @entity5 levels in erythrocytes may provide useful information for the detection of @entity1 .

title: Raised XXXX in erythrocytes from @entity3 -bearing @entity2 and @entity0 with solid @entity1 .

answer: @entity4


abstract: The levels of @entity4 ( @entity6 , @entity8 and @entity7 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity3 grown in the lungs of DBA/2 @entity2 . @entity5 levels and the numbers of @entity1 -cell colonies in the lungs were determined at weekly intervals. @entity6 levels in both erythrocytes and plasma significantly increased 1 week after @entity1 inoculation. Three weeks after inoculation, however, @entity6 levels in the erythrocytes showed a greater increase than those in plasma. @entity8 and @entity7 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity8 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4 released into the circulation.This finding was subsequently applied to @entity0 studies. Fifty-two untreated @entity0 with solid @entity1 were examined in the preoperative period. All erythrocyte @entity5 levels from @entity0 were significantly higher than those from control subjects. Plasma @entity8 levels in @entity0 were significantly higher than those in controls, whereas plasma @entity6 and @entity7 levels showed no significant increase. The frequency of raised levels of @entity6 , @entity8 and @entity7 in erythrocytes was significantly greater than in plasma. These results suggest that @entity5 levels in erythrocytes may provide useful information for the detection of @entity1 .

title: Raised @entity4 in erythrocytes from @entity3 -bearing @entity2 and @entity0 with solid XXXX .

answer: @entity1


abstract: The levels of @entity4 ( @entity6 , @entity8 and @entity7 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity3 grown in the lungs of DBA/2 @entity2 . @entity5 levels and the numbers of @entity1 -cell colonies in the lungs were determined at weekly intervals. @entity6 levels in both erythrocytes and plasma significantly increased 1 week after @entity1 inoculation. Three weeks after inoculation, however, @entity6 levels in the erythrocytes showed a greater increase than those in plasma. @entity8 and @entity7 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity8 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4 released into the circulation.This finding was subsequently applied to @entity0 studies. Fifty-two untreated @entity0 with solid @entity1 were examined in the preoperative period. All erythrocyte @entity5 levels from @entity0 were significantly higher than those from control subjects. Plasma @entity8 levels in @entity0 were significantly higher than those in controls, whereas plasma @entity6 and @entity7 levels showed no significant increase. The frequency of raised levels of @entity6 , @entity8 and @entity7 in erythrocytes was significantly greater than in plasma. These results suggest that @entity5 levels in erythrocytes may provide useful information for the detection of @entity1 .

title: Raised @entity4 in erythrocytes from @entity3 -bearing XXXX and @entity0 with solid @entity1 .

answer: @entity2


abstract: The levels of @entity4 ( @entity6 , @entity8 and @entity7 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity3 grown in the lungs of DBA/2 @entity2 . @entity5 levels and the numbers of @entity1 -cell colonies in the lungs were determined at weekly intervals. @entity6 levels in both erythrocytes and plasma significantly increased 1 week after @entity1 inoculation. Three weeks after inoculation, however, @entity6 levels in the erythrocytes showed a greater increase than those in plasma. @entity8 and @entity7 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity8 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4 released into the circulation.This finding was subsequently applied to @entity0 studies. Fifty-two untreated @entity0 with solid @entity1 were examined in the preoperative period. All erythrocyte @entity5 levels from @entity0 were significantly higher than those from control subjects. Plasma @entity8 levels in @entity0 were significantly higher than those in controls, whereas plasma @entity6 and @entity7 levels showed no significant increase. The frequency of raised levels of @entity6 , @entity8 and @entity7 in erythrocytes was significantly greater than in plasma. These results suggest that @entity5 levels in erythrocytes may provide useful information for the detection of @entity1 .

title: Raised @entity4 in erythrocytes from @entity3 -bearing @entity2 and XXXX with solid @entity1 .

answer: @entity0


abstract: The aim of the present study was to investigate, with extracellular recording and microiontophoretic techniques, the possibility that @entity3 ( @entity3 ) is the transmitter substance in the pallido-subthalamic (GP-STN) pathway. Experiments were carried out in 94 @entity0 , anesthetized with @entity5 . Among the 236 recorded STN neurons, 85 were inhibited by GP stimulation. This inhibition lasted 10--20 msec (mean duration +/- S.E.M. 13.45 +/- 0.5 msec). Control stimulations located either in the internal GP or in the striatum never elicited the same type of response as they did in the STN. STN neurons were inhibited by microiontophoretically applied @entity3 or @entity7 . Iontophoretically applied @entity2 or @entity6 reversibly blocked the GP-evoked inhibition at doses which blocked the @entity3 inhibitory responses but not those produced by @entity4 . The results are consistent with the hypothesis that @entity3 is the transmitter releasted by the inhibitory pallido-subthalamic pathway, and are in agreement with recent biochemical data. Nevertheless, on a few cells, @entity1 blocked the GP-induced inhibition. This results is discussed in relation to the specificty of @entity3 and @entity4 antagonists.

title: Pharmacological blockade of the globus palidus-induced inhibitory response of subthalamic cells in the XXXX .

answer: @entity0