abstract: OBJECTIVE: To determine whether @entity1 differ between @entity0 who undergo abdominal benign hysterectomy in a fast-track model under general anesthesia or spinal anesthesia with intrathecal @entity7 . DESIGN: Secondary analysis from a randomized, open, multicenter study. SETTING: Five hospitals in south-east Sweden. POPULATION: One-hundred and eighty @entity0 scheduled for benign hysterectomy were randomized; 162 completed the study; 82 were allocated to spinal and 80 to general anesthesia. METHODS: The Swedish Postoperative Symptoms Questionnaire, completed daily for 1 week and thereafter once a week until 5 weeks postoperatively. MAIN OUTCOME MEASURES: Occurrence, intensity and duration of @entity1 . RESULTS: @entity0 who had hysterectomy under spinal anesthesia with intrathecal @entity7 experienced significantly less discomfort postoperatively compared with those who had the operation under general anesthesia. Spinal anesthesia reduced the need for opioids postoperatively. The most common symptoms were @entity2 , @entity3 and @entity4 , itching, drowsiness and @entity8 . @entity5 , drowsiness and @entity8 occurred significantly less often and with lower intensity among the spinal anesthesia group. Although @entity6 was reported equally in the two groups, @entity4 episodes were reported significantly more often during the first day after surgery in the spinal anesthesia group. Spinal anesthesia was associated with a higher prevalence of postoperative itching. CONCLUSIONS: Spinal anesthesia with intrathecal @entity7 carries advantages regarding @entity1 and recovery following fast-track abdominal hysterectomy.

title: Mode of anesthesia and XXXX following abdominal hysterectomy in a fast-track setting.

answer: @entity1


abstract: BACKGROUND: The Index of Dental @entity1 (IDAF-4C) is a theoretically derived test developed to allow clinicians and researchers to measure a @entity0 's level of dental fear. Population norms have not previously been made available for the IDAF-4C. The aim of this study was to provide Australian norms for the IDAF-4C using percentile ranks and to examine associations between scores and individual-level characteristics, dental avoidance and fear of @entity2 . METHODS: A stratified random sample of 1511 Australian adults yielded complete questionnaire data for 1063 individuals (70.4%). Percentile ranks were calculated for IDAF-4C full scale scores stratified by age and gender. RESULTS: IDAF-4C mean scores varied significantly by age, gender, income, and speaking a language other than English at home. Tables to convert raw scores to percentiles showed that full scale scores varied by age and gender. Scores on the IDAF-4C had strong and significant associations with avoidance of the dentist due to fear, average dental visiting frequency and @entity1 about @entity2 when going to the dentist. CONCLUSIONS: Population norms allow clinicians or researchers to compare results for an individual or subgroup to the Australian population. It is recommended that a dental fear scale be used to screen all dental @entity0 for dental fear to enable a more tailored and effective dental treatment experience.

title: Australian population norms for the Index of Dental XXXX (IDAF-4C).

answer: @entity1


abstract: Intraocular foreign body (IOFB) is a common association of penetrating @entity5 . Early diagnosis and removal of IOFBs especially if they are metallic is very important to determine further management and the final result of treatment. Missed IOFB may present in different clinical aspects that may limit its detection and symptoms may only become apparent after a prolonged period of time. We report a case of a missed metallic intraocular foreign body in the anterior chamber over a 2-year period without causing severe inflammatory reaction and presented with @entity4 later. A 42-year-old @entity0 presented with a progressive @entity2 , @entity1 , @entity6 , and @entity5 for 3  months. He had a history of traffic accident 2  years ago and he was accepted to intensive care unit for 3  days. Three months ago, in another center, he was admitted to hospital for 1  week and intravitreal antibiotics and medical treatment were given for @entity1 , @entity6 , and redness in his left eye. In five o' clock meridian of the angle, there was an IOFB coated with hypopyon was observed under biomicrocopic magnification. Plain X-ray and computed tomography confirmed the foreign @entity3 . After obtaining informed consent from the @entity0 , the foreign body was removed under local anesthesia.

title: Anterior segment intraocular metallic foreign body causing XXXX .

answer: @entity4


abstract: Entrapment of @entity0 cells in natural or synthetic biomaterials represents an important tool for both basic and applied research in tissue engineering. For instance, the encapsulation procedures allow to physically isolate cells from the surrounding environment, after their transplantation maintaining the normal cellular physiology. The first part of the current paper describes different microencapsulation techniques including bulk emulsion technique, vibrating-nozzle procedure, gas driven mono-jet device protocol and microfluidic based approach. In the second part, the application of a microencapsulation procedure to the embedding of @entity0 cells is also described. @entity0 is a bronchial epithelial cell line, derived from a @entity4 ( @entity4 ) @entity0 . Different experimental parameters of the encapsulation process were analyzed, including frequency and amplitude of vibration, polymer pumping rate and distance between the nozzle and the gelling bath. We have found that the microencapsulation procedure does not alter the viability of the encapsulated @entity0 cells. The encapsulated @entity0 cells were characterized in term of protein secretion, analysing the culture medium by Bio-Plex strategy. The analyzed factors include members of the interleukin family ( @entity1 ), chemokines ( @entity2 and @entity5 ) and growth factors ( @entity3 ). The experiments demonstrated that most of the analyzed proteins, were secreted both by the free and encapsulated cells, even if in a different extent.

title: Encapsulation of eukaryotic cells in alginate microparticles: cell signaling by TNF-alpha through capsular structure of XXXX cells.

answer: @entity4


abstract: The brain of teleost fish exhibits a significant degree of sexual plasticity, even in adulthood. This unique feature is almost certainly attributable to a teleost-specific @entity1 , which remains largely unknown. To dissect the molecular basis of @entity1 , we searched for genes differentially expressed between both sexes in the @entity2 brain. One gene identified in the screen, @entity3 , which encodes the steroidogenic enzyme aromatase, was selected for further analysis. As opposed to the situation in most vertebrates, @entity2 @entity3 is expressed at higher levels in the adult female brain than the male brain. The female-biased expression in the brain is consistent regardless of reproductive or diurnal cycle. @entity2 @entity3 is expressed throughout the ventricular zones in wide areas of the brain, where, in most regions, females have a greater degree of expression compared to males, with the optic tectum exhibiting the most conspicuous predominance in females. Contrary to what is known in mammals, @entity3 expression exhibits neither a transient elevation nor a sex difference in @entity2 embryos. It is not until just before the onset of puberty that @entity3 expression in the @entity2 brain is sexually differentiated. Finally, @entity3 expression in the @entity2 brain is not under the direct control of sex chromosome genes but relies mostly, if not solely, on @entity0 derived from the gonad. These unique properties of aromatase expression in the brain probably contribute substantially to the less rigid sexual differentiation process, thus ensuring remarkable sexual plasticity in the teleost brain.

title: Sex differences in aromatase gene expression in the XXXX brain.

answer: @entity2


abstract: Threats of nuclear and other radiologic exposures have been increasing, but no countermeasure for @entity7 has been approved by regulatory authorities. Because of their similarity to @entity0 in regard to physiology and anatomy, we are characterizing Gottingen minipigs as a model to aid the development of radiation countermeasures. Irradiated minipigs exhibit immunosuppression, severe @entity6 , @entity5 , and acute @entity1 . These complications render serial acquisition of blood samples problematic. Vascular access ports (VAP) facilitate serial sampling, but their use often is complicated by @entity3 . We demonstrate here the successful use of VAP for multiple blood samplings in irradiated minipigs. Device design and limited postoperative prophylactic antimicrobial therapy before irradiation were key to obtaining serial sampling, reducing swelling, and eliminating @entity2 at the implantation site. Modifications of previous protocols included the use of @entity8 sutures instead of silk; eliminating chronic port access; single-use, sterile, antireflux prefilled syringes for flushing; strict aseptic weekly maintenance of the device, and acclimating animals to reduce stress. VAP remained functional in 19 of 20 irradiated animals for as long as 3 mo. The remaining VAP failed due to a small leak in the catheter, leading to clot formation. VAP-related @entity4 occurred in 2 minipigs. Blood sampling did not cause detectable stress in nonanesthetized sham-irradiated animals, according to leukograms and clinical signs.

title: Vascular access port implantation and serial blood sampling in a Gottingen minipig (Sus scrofa domestica) model of XXXX .

answer: @entity7


abstract: OBJECTIVES: To evaluate the changes in split renal function after retroperitoneal laparoscopic partial nephrectomy with @entity1 using ice-cold saline. METHODS: From June 2002 to October 2009, 32 @entity0 (median age 56 years) underwent retroperitoneal laparoscopic partial nephrectomy with @entity5 using ice-cold saline for the treatment of small @entity3 . The total renal function was monitored using the estimated glomerular filtration rate. Split renal function was evaluated using @entity6 renal scintigraphy preoperatively and 3 months postoperatively. RESULTS: The median renal ischemic time, including the initial 10 minutes for cooling, was 52 minutes (range 28-101). Of the @entity0 whose renal temperature was monitored, the lowest renal temperature during cooling was 15-25  C. The median decrease in the estimated glomerular filtration rate was 7.2 mL/ @entity4 .73 m(2) (range -16.3 to 33.7). The median decrease in the contribution of the affected @entity1 was 5.3% (range 0.4%-21.1%). On multivariate analysis, a shorter @entity2 duration was an independent predictor of a lesser decrease in the contribution of the affected kidney (P = .0032). CONCLUSIONS: The methods we have described are simple and effective to facilitate suboptimal @entity5 . The decrease in the renal contribution of the affected kidney appeared to be minimal, although the ischemic time was relatively longer in our series.

title: XXXX using ice-cold saline for retroperitoneal laparoscopic partial nephrectomy: evaluation of split renal function with @entity6 renal scintigraphy.

answer: @entity1


abstract: OBJECTIVES: To evaluate the changes in split renal function after retroperitoneal laparoscopic partial nephrectomy with @entity1 using ice-cold saline. METHODS: From June 2002 to October 2009, 32 @entity0 (median age 56 years) underwent retroperitoneal laparoscopic partial nephrectomy with @entity5 using ice-cold saline for the treatment of small @entity3 . The total renal function was monitored using the estimated glomerular filtration rate. Split renal function was evaluated using @entity6 renal scintigraphy preoperatively and 3 months postoperatively. RESULTS: The median renal ischemic time, including the initial 10 minutes for cooling, was 52 minutes (range 28-101). Of the @entity0 whose renal temperature was monitored, the lowest renal temperature during cooling was 15-25  C. The median decrease in the estimated glomerular filtration rate was 7.2 mL/ @entity4 .73 m(2) (range -16.3 to 33.7). The median decrease in the contribution of the affected @entity1 was 5.3% (range 0.4%-21.1%). On multivariate analysis, a shorter @entity2 duration was an independent predictor of a lesser decrease in the contribution of the affected kidney (P = .0032). CONCLUSIONS: The methods we have described are simple and effective to facilitate suboptimal @entity5 . The decrease in the renal contribution of the affected kidney appeared to be minimal, although the ischemic time was relatively longer in our series.

title: @entity1 using ice-cold saline for retroperitoneal laparoscopic partial nephrectomy: evaluation of split renal function with XXXX renal scintigraphy.

answer: @entity6


abstract: BACKGROUND: The Urban Environment and Childhood Asthma study was established to investigate the immunologic and environmental causes of @entity5 in inner-city @entity0 . OBJECTIVE: We sought to evaluate potential atopic outcomes in the first 12 months and their relationships to environmental exposures and immune development. METHODS: A birth cohort of 560 @entity0 with at least 1 parent with @entity6 or @entity5 was established in Baltimore, Boston, New York, and St Louis. Wheezing is assessed every 3 months, allergen-specific IgE yearly, and mononuclear cell cytokine responses at birth and yearly; environmental assessments include dust allergen and endotoxin, maternal stress, and indoor @entity7 and @entity9 levels. RESULTS: Key outcomes in the first year include wheeze in 49%, 2 or more episodes of wheeze in 23%, @entity4 in 30%, and detectable IgE to milk, egg, and/or peanut in 32% and to cockroach in 4%. Household dust revealed levels of greater than 2  g/g to cockroach in 40%, mite in 19%, cat in 25%, and @entity1 in 29%, and 66% of homes housed at least 1 smoker. Positive associations were detected between multiple wheeze and @entity8 levels, maternal stress, and maternal @entity3 , whereas cytokine responses to a variety of innate, adaptive, and mitogenic stimuli were inversely related to @entity4 . CONCLUSIONS: This high-risk cohort of inner-city @entity0 is exhibiting high rates of wheeze, @entity2 . Low cytokine responses at birth might be a risk factor for @entity4 , whereas a variety of adverse environmental exposures contribute to the risk of wheezing in infancy. These findings provide evidence of specificity in the interactions between immune development, environmental exposures, and the development of early features that might predict future @entity5 .

title: Relationships among environmental exposures, cord blood cytokine responses, XXXX , and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study).

answer: @entity6


abstract: BACKGROUND AND AIM: The relationship between @entity2 ( @entity2 ) and the prognosis of @entity0 still remains controversial. The aim of the present study was to investigate the prognostic significance of morphologic features of the microvessels in @entity0 with @entity2 after resection. METHODS: The paraffin-embedding specimens of 98 consecutive @entity2 @entity0 , who received primary resection between 2000 and 2002, were collected from our prospective established @entity1 bank. The intratumoral microvessels were evaluated by immunohistochemical staining for @entity4 and @entity5 . The disease-free survival (DFS) and @entity3 ( @entity3 ) of @entity0 were analyzed by Kaplan-Meier analysis and Cox proportional hazards regression model. RESULTS: There are two distinct microvessel types: capillary-like and sinusoid-like were identified in @entity1 tissues. The @entity0 could be divided into two groups according to their microvessel types. Both DFS and @entity3 of capillary group @entity0 (n = 65) were better than those of sinusoid group @entity0 (n = 33). Multivariate analyses showed that the microvessel type was an independent risk factor for DFS (P = 0.016) and @entity3 (P = 0.004) of this cohort. Capillary-like microvessels were more common in small @entity2 , and were significantly associated with higher microvessel density, while sinusoid-like microvessels were significantly correlated with lower microvessel density. CONCLUSIONS: The results of our study suggested that the microvessel type is an effective predictor of survival in @entity0 with @entity2 after resection, which might serve as potential novel therapeutic targets for prevention of the recurrence of @entity2 after resection.

title: Morphologic classification of microvessels in XXXX is associated with the prognosis after resection.

answer: @entity2


abstract: BACKGROUND: @entity4 is becoming an important health problem in Spain, a country with the third highest level of fish consumption after Japan and Portugal. The most common fish allergens are parvalbumins. In our area, the most widely consumed fish species are lean, such as whiff (Lepidorhombus whiffiagonis) and sole (Solea solea). Adverse reactions to fish are usually related to these species, a fact that is largely unknown to allergists in other countries. OBJECTIVE: The aim of this study was to identify and purify the major allergen implicated in @entity1 response to sole and evaluate the IgE cross-reactivity of purified parvalbumins from whiff and sole, which are phylogenetically close, and more distant species (i.e. cod and salmon). METHODS: Eighteen Spanish fish- @entity1 @entity0 with a positive history of type I @entity3 to fish were recruited from the clinic. Total protein extracts and purified parvalbumins from whiff and sole were tested for their IgE-binding properties by combining two-dimensional Western blotting and mass spectrometry. The extent of cross-reactivity between these parvalbumins along with cod and salmon parvalbumins was investigated by IgE ELISA inhibition assay. RESULTS: An IgE-binding spot of approximately 14 kDa was identified as @entity5 and confirmed as a major allergen in sole extract, which is recognized by almost 70% of the @entity0 . Whiff @entity5 was recognized by 83.4% of the @entity0 . High cross-reactivity was determined for all purified parvalbumins by IgE inhibition assay. CONCLUSIONS AND CLINICAL RELEVANCE: Sole and whiff @entity5 were confirmed as major allergens. The parvalbumins of sole, whiff, cod and salmon were highly cross-reactive, thus suggesting a high @entity2 sequence identity between them.

title: Identification of sole @entity5 as a major allergen: study of cross-reactivity between parvalbumins in a Spanish fish- XXXX population.

answer: @entity1


abstract: BACKGROUND: @entity4 is becoming an important health problem in Spain, a country with the third highest level of fish consumption after Japan and Portugal. The most common fish allergens are parvalbumins. In our area, the most widely consumed fish species are lean, such as whiff (Lepidorhombus whiffiagonis) and sole (Solea solea). Adverse reactions to fish are usually related to these species, a fact that is largely unknown to allergists in other countries. OBJECTIVE: The aim of this study was to identify and purify the major allergen implicated in @entity1 response to sole and evaluate the IgE cross-reactivity of purified parvalbumins from whiff and sole, which are phylogenetically close, and more distant species (i.e. cod and salmon). METHODS: Eighteen Spanish fish- @entity1 @entity0 with a positive history of type I @entity3 to fish were recruited from the clinic. Total protein extracts and purified parvalbumins from whiff and sole were tested for their IgE-binding properties by combining two-dimensional Western blotting and mass spectrometry. The extent of cross-reactivity between these parvalbumins along with cod and salmon parvalbumins was investigated by IgE ELISA inhibition assay. RESULTS: An IgE-binding spot of approximately 14 kDa was identified as @entity5 and confirmed as a major allergen in sole extract, which is recognized by almost 70% of the @entity0 . Whiff @entity5 was recognized by 83.4% of the @entity0 . High cross-reactivity was determined for all purified parvalbumins by IgE inhibition assay. CONCLUSIONS AND CLINICAL RELEVANCE: Sole and whiff @entity5 were confirmed as major allergens. The parvalbumins of sole, whiff, cod and salmon were highly cross-reactive, thus suggesting a high @entity2 sequence identity between them.

title: Identification of sole XXXX as a major allergen: study of cross-reactivity between parvalbumins in a Spanish fish- @entity1 population.

answer: @entity5


abstract: Background. Many factors are responsible for this @entity1 , especially in long bones, but a possible genetic predisposition for the development of this complication remains unknown till now. In the present study, we aim to examine the @entity3 gene polymorphism in @entity2 nonunion @entity0 and the correlation with clinical findings. Materials and Methods. We performed SNP analysis of the @entity3 gene in 250 @entity2 nonunion @entity0 and 250 healthy subjects were genotyped in this hospital-based case control study, and 56 cases were further evaluated for mRNA expression of @entity3 by real-time quantitative reverse-transcription PCR. Results. @entity3 gene TT, TG, and GG genotype frequencies of total @entity2 nonunion cases were 41.6%, 49.2%, and 9.20% and 54.4%, 39.2%, and 6.40% in healthy controls. Heterozygous TG genotype was found statistically significant in @entity2 nonunion cases compared with that in controls, whereas homozygous mutant GG genotype was not found significant. Moreover, we found that TG + GG genotypes were significantly different in serum expression of @entity3 mRNA when compared with cases (TT genotypes). Conclusions. Our result signifies that genotype of @entity3 affects the mRNA expression and acts as a risk factor that could synergistically increase the susceptibility of a @entity0 to develop @entity2 nonunion.

title: Study of Cysteine-Rich Protein 61 Genetic Polymorphism in Predisposition to XXXX : A Case Control.

answer: @entity2


abstract: Racial/ethnic disparities in female @entity0 survival continue to persist in United States. However, disparities comparing @entity4 ( @entity4 ), Asians and Caucasians remain to be assessed. We aimed to assess multiracial/ethnic disparities in @entity0 survival, and to examine the factors that may explain the variability. A total of 6,951 @entity1 diagnosed with @entity0 between 1992 and 1998 were identified from surveillance, epidemiology, and end results @entity2 registries. The effect of race/ethnicity and the prognostic factors on survival was assessed using Cox proportional hazard model. @entity4 demonstrated a @entity3 . Compared to Asians, Caucasians had 74% increased risk of dying (HR = 1.74, 95% CI = 1.31-2.33), while @entity4 were almost three times as likely as Asians to die, (HR = 2.78, 95% CI 2.02-3.86). After adjustment for the relevant covariates the @entity3 of @entity4 persisted. Relative to Asians, Caucasians were 45% more likely to die (HR = 1.45, 95% CI 1.10-1.93), while @entity4 were more than two times as likely to die (HR = 2.57, 95% CI 1.86-3.55). There were substantial racial/ethnic disparities in @entity0 survival among United States @entity1 . @entity4 demonstrated @entity3 compared with either Caucasia ns or Asians, which persisted even after controlling factors known to influence @entity0 survival.

title: A five-year XXXX -specific @entity3 of African American @entity1 .

answer: @entity0


abstract: Racial/ethnic disparities in female @entity0 survival continue to persist in United States. However, disparities comparing @entity4 ( @entity4 ), Asians and Caucasians remain to be assessed. We aimed to assess multiracial/ethnic disparities in @entity0 survival, and to examine the factors that may explain the variability. A total of 6,951 @entity1 diagnosed with @entity0 between 1992 and 1998 were identified from surveillance, epidemiology, and end results @entity2 registries. The effect of race/ethnicity and the prognostic factors on survival was assessed using Cox proportional hazard model. @entity4 demonstrated a @entity3 . Compared to Asians, Caucasians had 74% increased risk of dying (HR = 1.74, 95% CI = 1.31-2.33), while @entity4 were almost three times as likely as Asians to die, (HR = 2.78, 95% CI 2.02-3.86). After adjustment for the relevant covariates the @entity3 of @entity4 persisted. Relative to Asians, Caucasians were 45% more likely to die (HR = 1.45, 95% CI 1.10-1.93), while @entity4 were more than two times as likely to die (HR = 2.57, 95% CI 1.86-3.55). There were substantial racial/ethnic disparities in @entity0 survival among United States @entity1 . @entity4 demonstrated @entity3 compared with either Caucasia ns or Asians, which persisted even after controlling factors known to influence @entity0 survival.

title: A five-year @entity0 -specific XXXX of African American @entity1 .

answer: @entity3


abstract: Racial/ethnic disparities in female @entity0 survival continue to persist in United States. However, disparities comparing @entity4 ( @entity4 ), Asians and Caucasians remain to be assessed. We aimed to assess multiracial/ethnic disparities in @entity0 survival, and to examine the factors that may explain the variability. A total of 6,951 @entity1 diagnosed with @entity0 between 1992 and 1998 were identified from surveillance, epidemiology, and end results @entity2 registries. The effect of race/ethnicity and the prognostic factors on survival was assessed using Cox proportional hazard model. @entity4 demonstrated a @entity3 . Compared to Asians, Caucasians had 74% increased risk of dying (HR = 1.74, 95% CI = 1.31-2.33), while @entity4 were almost three times as likely as Asians to die, (HR = 2.78, 95% CI 2.02-3.86). After adjustment for the relevant covariates the @entity3 of @entity4 persisted. Relative to Asians, Caucasians were 45% more likely to die (HR = 1.45, 95% CI 1.10-1.93), while @entity4 were more than two times as likely to die (HR = 2.57, 95% CI 1.86-3.55). There were substantial racial/ethnic disparities in @entity0 survival among United States @entity1 . @entity4 demonstrated @entity3 compared with either Caucasia ns or Asians, which persisted even after controlling factors known to influence @entity0 survival.

title: A five-year @entity0 -specific @entity3 of African American XXXX .

answer: @entity1


abstract: IMPORTANCE: @entity3 ( @entity3 ) is a progressive, fatal disease with no known cause. Case studies primarily of athletes and several case-control studies have suggested that high levels of strenuous physical activity (PA) may increase the risk for @entity3 . This relationship has yet to be evaluated among @entity1 in population-based cohort studies. OBJECTIVE: To evaluate the relationship between PA and risk for @entity3 mortality in a large cohort of postmenopausal @entity1 . DESIGN, SETTING, AND @entity1 : The @entity1 's Health Initiative (WHI) enrolled 161   809 postmenopausal @entity1 , aged 50 to 79 years (mean [SD] age, 63.6 [7.24] years), between 1993 and 1998 into either a clinical trial or an observational study at 40 clinical research centers across the United States. We conducted a cohort study from November 2014 to September 2015 using baseline and mortality data during an average of 9.6 years of follow-up from the entire WHI cohort, through September 1, 2013 (with 1.1% lost to follow-up), to address whether there is a relationship between PA and @entity3 mortality. EXPOSURES: The WHI assessed frequency and duration of mild, moderate, and strenuous PA at baseline via self-administered questionnaire. MAIN OUTCOMES AND MEASURES: Underlying cause of death from @entity3 collected from death certificates. RESULTS: The WHI enrolled 161   809 @entity1 , of whom 165 died of @entity3 ; @entity1 who died of @entity3 were older (median age, 66 years; interquartile range, 61-69 years) compared with the total WHI study population (median age, 63 years; interquartile range, 57-69 years). Age-adjusted @entity3 mortality rates varied from 7.4 (95% CI, 5.5-9.9)/100   000 @entity1 -years for no strenuous PA to 10.6 (95% CI, 5.6-20.0)/100   000 @entity1 -years for strenuous PA 3 or more days per week (P   =   .07). Adjusted for age and body mass index (calculated as weight in kilograms divided by height in meters squared), the odds ratio for death from @entity3 for @entity1 with strenuous PA 3 or more days per week compared with no reported strenuous PA was 1.56 (95% CI, 1.02-2.37; P   =   .04). CONCLUSIONS AND RELEVANCE: To our knowledge, this is the first cohort study to report an increased risk for @entity3 mortality associated with strenuous PA in postmenopausal @entity1 . The association between strenuous PA and @entity3 risk observed does not compromise the overall benefit of strenuous PA for total mortality, @entity2 , and @entity0 reported in other WHI investigations, but it may provide an important clue to the etiology of @entity3 , if replicated by other studies.

title: Participation in Physical Activity and Risk for Amyotrophic Lateral Sclerosis Mortality Among Postmenopausal XXXX .

answer: @entity1


abstract: The increase in levels of free @entity1 (FFA) in morning and afternoon milk after 48 h cold storage at 5 degrees C was determined at two stages of lactation in milk from 96 @entity0 . Lipolysis was positively correlated to day of lactation (r = 0.6, P less than 0.001), while the correlations between lipolysis and milk yield and fat content respectively were due to these factors being related to day of lactation. In afternoon milk the level of FFA increased almost three times above that in morning milk. Lipolysis was closely related to the @entity2 ( @entity2 ) activity associated with the cream fraction (r = 0.8, P less than 0.001). Afternoon milk had higher @entity2 activity in the cream fraction than morning milk. Lipase activity in the cream increased with increasing stage of lactation. Cooling of milk increased @entity2 activity associated with the fat phase. This effect was greater in afternoon milk from late lactation than in morning milk from early lactation. When heparin was added to milk the @entity2 activity associated with the fat increased substantially; again, this effect was greater in afternoon milk from late lactation than in morning milk from early lactation. Lipolysis was higher in heparinized milk than in normal milk, and there was a close correlation between lipolysis and @entity2 activity associated with the fat (r = 0.82, P less than 0.001). Characteristics of the milk fat globule influencing the attraction of @entity2 were found to be fundamentally important to lipolysis.

title: Lipolysis and the distribution of lipase activity in XXXX milk in relation to stage of lactation and time of milking.

answer: @entity0


abstract: Eight Holstein @entity0 were assigned to two groups of four each, and a switchback design was used. Treatments were 4 mA of alternating current and no current. Four periods were each 96 h. Current was applied across subdermal electrodes, located on each @entity0 's spine for 30 s, with a 30-s rest period between exposures for 5 min. @entity0 received current every 4 h for four 24-h intervals. No individual @entity0 received current at the same time every day. @entity1 yield was reduced .16 kg/milking by exposure to 4 mA current. This decrease was not statistically significant. Percent @entity1 fat and @entity1 protein were not changed by current. Overall numbers of @entity1 somatic cells were variable during the experiment. They increased during exposure to current, yet the increase was not statistically significant. Overall mean feed consumption and water consumption were not affected by treatments. The greatest behavioral response to current was upon initial exposure. @entity0 became accustomed to shock within 24 h of exposure. By the end of the fourth 96-h period of exposure, behavioral responses to current were almost extinct. We conclude that exposing @entity0 to 4 mA of alternating current, in a semirandomized nonavoidance environment, for four consecutive 24-h intervals does not alter @entity1 yield, @entity1 composition, or intake of feed and water.

title: Responses of dairy XXXX to alternating electrical current administered semirandomly in a nonavoidance environment.

answer: @entity0


abstract: BACKGROUND: The standard treatment for @entity0 with advanced transitional cell @entity4 is platin based chemotherapy. Only approximately 50% of the @entity0 respond to chemotherapy. Therefore, molecular predictive markers for identification of chemotherapy sensitive subgroups of @entity0 are highly needed. We selected the transcription factor @entity8 from a previously identified gene expression signature for chemotherapy response. METHODS: @entity8 expression and localization was assessed by immunohistochemistry using a tissue microarray (TMA) containing 282 @entity4 tumors from @entity0 with locally advanced (pT2-T4(b) and N(1-3)) or metastatic (M(1)) disease. All @entity0 had received @entity6 containing chemotherapy. Furthermore, QPCR analysis of three @entity8 isoforms was performed on @entity2 specimens of advanced muscle invasive @entity4 (T2-4). Using the bladder cell lines T24 and SW780 the relation of @entity8 and @entity6 and @entity3 sensitivity as well as cell proliferation was examined using siRNA directed @entity8 knockdown. RESULTS: @entity8 protein expression was analyzed on a @entity7 with cores from 282 advanced @entity4 tumors from @entity0 treated with @entity6 based combinational chemotherapy. @entity8 was identified as a strong independent predictive marker for a good response and survival after @entity6 -containing chemotherapy in @entity0 with advanced @entity4 . Strong @entity8 nuclear and cytoplasmic staining predicted good response to chemotherapy in @entity0 with lymph node @entity1 , whereas weak @entity8 nuclear staining predicted good response in @entity0 without lymph node @entity1 . In vitro studies showed that siRNA mediated knockdown of @entity8 increased the proliferation of @entity0 cells and rendered the cells less sensitive to @entity6 and @entity3 . In contrast to that @entity0 bladder cells with mutated @entity5 showed to be more drug sensitive upon @entity8 depletion. CONCLUSIONS: High levels of nuclear and cytoplasmic @entity8 protein were a predictor of increased overall survival and progression free survival in @entity0 with advanced @entity4 treated with @entity6 based chemotherapy. @entity8 knockdown increased the proliferation of the @entity0 bladder cells and reduced @entity6 and @entity3 induced cell death. The inverse effect was observed in the @entity5 mutated @entity0 cell line where @entity8 silencing augmented @entity6 and @entity3 sensitivity and did not stimulate proliferation.

title: Increased expression of transcription factor @entity8 correlates with chemosensitivity in advanced XXXX .

answer: @entity4


abstract: BACKGROUND: The standard treatment for @entity0 with advanced transitional cell @entity4 is platin based chemotherapy. Only approximately 50% of the @entity0 respond to chemotherapy. Therefore, molecular predictive markers for identification of chemotherapy sensitive subgroups of @entity0 are highly needed. We selected the transcription factor @entity8 from a previously identified gene expression signature for chemotherapy response. METHODS: @entity8 expression and localization was assessed by immunohistochemistry using a tissue microarray (TMA) containing 282 @entity4 tumors from @entity0 with locally advanced (pT2-T4(b) and N(1-3)) or metastatic (M(1)) disease. All @entity0 had received @entity6 containing chemotherapy. Furthermore, QPCR analysis of three @entity8 isoforms was performed on @entity2 specimens of advanced muscle invasive @entity4 (T2-4). Using the bladder cell lines T24 and SW780 the relation of @entity8 and @entity6 and @entity3 sensitivity as well as cell proliferation was examined using siRNA directed @entity8 knockdown. RESULTS: @entity8 protein expression was analyzed on a @entity7 with cores from 282 advanced @entity4 tumors from @entity0 treated with @entity6 based combinational chemotherapy. @entity8 was identified as a strong independent predictive marker for a good response and survival after @entity6 -containing chemotherapy in @entity0 with advanced @entity4 . Strong @entity8 nuclear and cytoplasmic staining predicted good response to chemotherapy in @entity0 with lymph node @entity1 , whereas weak @entity8 nuclear staining predicted good response in @entity0 without lymph node @entity1 . In vitro studies showed that siRNA mediated knockdown of @entity8 increased the proliferation of @entity0 cells and rendered the cells less sensitive to @entity6 and @entity3 . In contrast to that @entity0 bladder cells with mutated @entity5 showed to be more drug sensitive upon @entity8 depletion. CONCLUSIONS: High levels of nuclear and cytoplasmic @entity8 protein were a predictor of increased overall survival and progression free survival in @entity0 with advanced @entity4 treated with @entity6 based chemotherapy. @entity8 knockdown increased the proliferation of the @entity0 bladder cells and reduced @entity6 and @entity3 induced cell death. The inverse effect was observed in the @entity5 mutated @entity0 cell line where @entity8 silencing augmented @entity6 and @entity3 sensitivity and did not stimulate proliferation.

title: Increased expression of transcription factor XXXX correlates with chemosensitivity in advanced @entity4 .

answer: @entity8


abstract: BACKGROUND: Fraction of exhaled @entity4 (Feno), a marker of airway @entity1 , has been proposed to be useful for @entity2 management, but conclusions are inconsistent. This might be due to the failure of mean statistics to characterize individual variability in Feno values, which is possibly a better indicator of @entity2 control than single measurements. OBJECTIVE: We characterized fractal fluctuations in daily Feno values over time and the relationship between Feno values and symptom scores. We investigated whether these are associated with @entity2 severity, control, and exacerbation risk. METHODS: Daily Feno values and symptom scores over 192 days in 41 atopic @entity3 @entity0 from the Childhood Asthma Respiratory Inflammatory Status Monitoring study were analyzed. Two methods of time-series analysis were used: detrended fluctuation analysis to quantify fractal patterns in fluctuations in daily Feno values (a value) and cross-correlation to quantify the strength of the relationship between daily Feno values and symptom scores. The associations of a values and cross-correlation with markers of @entity2 severity and control were assessed by means of regression analysis. RESULTS: Daily fluctuations in Feno values exhibited fractal-type long-range correlations. Those subjects receiving higher doses of inhaled corticosteroids at study entry had a significantly lower a value, corresponding to more random fluctuations in Feno values in those with greater inhaled corticosteroid need. The cross-correlation between Feno values and symptom scores was significantly higher in those subjects who had exacerbations. CONCLUSIONS: Fluctuation in Feno values and their cross-correlation to symptom scores contains information on @entity2 severity and control. Methods that quantify the complexity of @entity2 over time might assist in identifying @entity3 subjects with concordance between eosinophilic @entity1 and symptoms and thus increased exacerbation risk.

title: Fluctuation phenotyping based on daily fraction of exhaled XXXX values in @entity3 @entity0 .

answer: @entity4


abstract: BACKGROUND: Fraction of exhaled @entity4 (Feno), a marker of airway @entity1 , has been proposed to be useful for @entity2 management, but conclusions are inconsistent. This might be due to the failure of mean statistics to characterize individual variability in Feno values, which is possibly a better indicator of @entity2 control than single measurements. OBJECTIVE: We characterized fractal fluctuations in daily Feno values over time and the relationship between Feno values and symptom scores. We investigated whether these are associated with @entity2 severity, control, and exacerbation risk. METHODS: Daily Feno values and symptom scores over 192 days in 41 atopic @entity3 @entity0 from the Childhood Asthma Respiratory Inflammatory Status Monitoring study were analyzed. Two methods of time-series analysis were used: detrended fluctuation analysis to quantify fractal patterns in fluctuations in daily Feno values (a value) and cross-correlation to quantify the strength of the relationship between daily Feno values and symptom scores. The associations of a values and cross-correlation with markers of @entity2 severity and control were assessed by means of regression analysis. RESULTS: Daily fluctuations in Feno values exhibited fractal-type long-range correlations. Those subjects receiving higher doses of inhaled corticosteroids at study entry had a significantly lower a value, corresponding to more random fluctuations in Feno values in those with greater inhaled corticosteroid need. The cross-correlation between Feno values and symptom scores was significantly higher in those subjects who had exacerbations. CONCLUSIONS: Fluctuation in Feno values and their cross-correlation to symptom scores contains information on @entity2 severity and control. Methods that quantify the complexity of @entity2 over time might assist in identifying @entity3 subjects with concordance between eosinophilic @entity1 and symptoms and thus increased exacerbation risk.

title: Fluctuation phenotyping based on daily fraction of exhaled @entity4 values in XXXX @entity0 .

answer: @entity3


abstract: BACKGROUND: Fraction of exhaled @entity4 (Feno), a marker of airway @entity1 , has been proposed to be useful for @entity2 management, but conclusions are inconsistent. This might be due to the failure of mean statistics to characterize individual variability in Feno values, which is possibly a better indicator of @entity2 control than single measurements. OBJECTIVE: We characterized fractal fluctuations in daily Feno values over time and the relationship between Feno values and symptom scores. We investigated whether these are associated with @entity2 severity, control, and exacerbation risk. METHODS: Daily Feno values and symptom scores over 192 days in 41 atopic @entity3 @entity0 from the Childhood Asthma Respiratory Inflammatory Status Monitoring study were analyzed. Two methods of time-series analysis were used: detrended fluctuation analysis to quantify fractal patterns in fluctuations in daily Feno values (a value) and cross-correlation to quantify the strength of the relationship between daily Feno values and symptom scores. The associations of a values and cross-correlation with markers of @entity2 severity and control were assessed by means of regression analysis. RESULTS: Daily fluctuations in Feno values exhibited fractal-type long-range correlations. Those subjects receiving higher doses of inhaled corticosteroids at study entry had a significantly lower a value, corresponding to more random fluctuations in Feno values in those with greater inhaled corticosteroid need. The cross-correlation between Feno values and symptom scores was significantly higher in those subjects who had exacerbations. CONCLUSIONS: Fluctuation in Feno values and their cross-correlation to symptom scores contains information on @entity2 severity and control. Methods that quantify the complexity of @entity2 over time might assist in identifying @entity3 subjects with concordance between eosinophilic @entity1 and symptoms and thus increased exacerbation risk.

title: Fluctuation phenotyping based on daily fraction of exhaled @entity4 values in @entity3 XXXX .

answer: @entity0


abstract: BACKGROUND: American football and rugby players are at substantial risk of injury because of the full-contact nature of these sports. Methodological differences between previous epidemiological studies hamper an accurate comparison of injury rates between American football and rugby. PURPOSE: To directly compare injury rates in American collegiate football and rugby, specified by location, type, mechanism, and severity of injury, as reported by licensed medical professionals. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: Licensed medical professionals (athletic trainer or physician) associated with the football and rugby teams of a National Collegiate Athletic Association Division I university reported attendance and @entity0 over 3 autumn seasons. Injuries were categorized by the location, type, mechanism, and severity of injury, and the injury rate was calculated per 1000 athlete-exposures (AEs). Injury rate ratios (IRRs) were calculated to compare overall, game, and practice injury rates within and between sports. RESULTS: The overall injury rate was 4.9/1000 AEs in football versus 15.2/1000 AEs in rugby: @entity3 = 3.1 (95% CI, 2.3-4.2). @entity0 rates were higher than practice injury rates: @entity3 = 6.5 (95% CI, 4.5-9.3) in football and @entity3 = 5.1 (95% CI, 3.0-8.6) in rugby. Injury rates for the shoulder, wrist/hand, and lower leg and for @entity2 , @entity1 , and contusions in rugby were >4 times as high as those in football (all P  <= 0.006). Concussion rates were 1.0/1000 AEs in football versus 2.5/1000 AEs in rugby. Most injuries occurred via direct player contact, especially during games. The rate of season-ending injuries (>3 months of time loss) was 0.8/1000 AEs in football versus 1.0/1000 AEs in rugby: @entity3 = 1.3 (95% CI, 0.4-3.4). CONCLUSION: Overall injury rates were substantially higher in collegiate rugby compared with football. Similarities between sports were observed in the most common @entity0 ( @entity2 and concussions), locations (lower extremity and head), and mechanisms (direct player contact). @entity0 were more common in rugby, and the rate of season-ending injuries was similar between sports.

title: XXXX in American Collegiate Football and Club Rugby: A Prospective Cohort Study.

answer: @entity0


abstract: BACKGROUND: @entity1 care practitioner training is essential for professional caregivers to acquire medical knowledge and care skills for @entity1 @entity0 . We investigated the significance of training in stress management by evaluating caregivers' job stress and coping style before and after they have completed training. METHODS: The subjects included 134 professional caregivers (41 @entity0 , 93 @entity0 ) recruited from @entity0 in training programmes held in Kanagawa Prefecture from August 2008 to March 2010. A survey using a brief job stress questionnaire and a coping scale was carried out before and after they completed their training. A t-test and multiple regression analysis were performed to evaluate the effects of the training. RESULT: After the training, the scores of modifiers on the job stress scale and of the coping scale increased, whereas the scores of stress reactions on the job stress scale decreased. However, there were no changes in @entity0 ' subjective cognition concerning their workplace environment. Furthermore, the change in stress reaction score tended to correlate with the change in consultation score in all @entity0 and with the change in problem-solving and consultation in male @entity0 . Among female @entity0 , the change in stress reaction score tended to correlate with change in support from superiors and colleagues as modifiers. The factors that correlated to the change in stress reaction score differed between genders. CONCLUSION: The findings suggest that training caregivers improves their stress reaction and coping skills.

title: Changes in job stress and coping skills among caregivers after XXXX care practitioner training.

answer: @entity1


abstract: The purpose of this study was to determine whether lipoprotein-bound free @entity3 could be utilized by isolated @entity0 cells. Ehrlich ascites @entity1 cells were incubated in vitro with radioactive free @entity4 that were bound to @entity0 plasma lipoproteins. Under these conditions, lipoprotein-bound free @entity4 were readily taken up by the cells. After 2 min of incubation with free @entity4 bound to low density lipoproteins, most of the radioactivity that was associated with the cells was in the form of free @entity4 . As the incubation continued, increasing amounts of radioactivity were incorporated into @entity2 and cell lipids, particularly phospholipids. Most of the free @entity3 uptake was the result of @entity3 transfer from low density lipoproteins to the cell, not from irreversible incorporation of the intact free @entity3 -low density lipoprotein complex. @entity3 uptake increased as the ratio of free @entity3 to low density lipoprotein was raised. When albumin was added to the medium, free @entity3 uptake decreased. A large percentage of the newly incorporated cellular radioactivity was released into the medium if the cells were exposed subsequently to a solution containing albumin. Most of the released radioactivity was in the form of free @entity3 . The results with this experimental model suggest that lipoprotein-bound free @entity3 , like albumin-bound free @entity3 , is readily available for uptake by isolated cells. The mechanism of free @entity3 utilization by the Ehrlich cell is similar when either low density lipoprotein or serum albumin serves as the @entity3 carrier.

title: Utilization of free XXXX complexed to @entity0 plasma lipoproteins by @entity0 cell suspensions.

answer: @entity4


abstract: The purpose of this study was to determine whether lipoprotein-bound free @entity3 could be utilized by isolated @entity0 cells. Ehrlich ascites @entity1 cells were incubated in vitro with radioactive free @entity4 that were bound to @entity0 plasma lipoproteins. Under these conditions, lipoprotein-bound free @entity4 were readily taken up by the cells. After 2 min of incubation with free @entity4 bound to low density lipoproteins, most of the radioactivity that was associated with the cells was in the form of free @entity4 . As the incubation continued, increasing amounts of radioactivity were incorporated into @entity2 and cell lipids, particularly phospholipids. Most of the free @entity3 uptake was the result of @entity3 transfer from low density lipoproteins to the cell, not from irreversible incorporation of the intact free @entity3 -low density lipoprotein complex. @entity3 uptake increased as the ratio of free @entity3 to low density lipoprotein was raised. When albumin was added to the medium, free @entity3 uptake decreased. A large percentage of the newly incorporated cellular radioactivity was released into the medium if the cells were exposed subsequently to a solution containing albumin. Most of the released radioactivity was in the form of free @entity3 . The results with this experimental model suggest that lipoprotein-bound free @entity3 , like albumin-bound free @entity3 , is readily available for uptake by isolated cells. The mechanism of free @entity3 utilization by the Ehrlich cell is similar when either low density lipoprotein or serum albumin serves as the @entity3 carrier.

title: Utilization of free @entity4 complexed to XXXX plasma lipoproteins by @entity0 cell suspensions.

answer: @entity0


abstract: The purpose of this study was to determine whether lipoprotein-bound free @entity3 could be utilized by isolated @entity0 cells. Ehrlich ascites @entity1 cells were incubated in vitro with radioactive free @entity4 that were bound to @entity0 plasma lipoproteins. Under these conditions, lipoprotein-bound free @entity4 were readily taken up by the cells. After 2 min of incubation with free @entity4 bound to low density lipoproteins, most of the radioactivity that was associated with the cells was in the form of free @entity4 . As the incubation continued, increasing amounts of radioactivity were incorporated into @entity2 and cell lipids, particularly phospholipids. Most of the free @entity3 uptake was the result of @entity3 transfer from low density lipoproteins to the cell, not from irreversible incorporation of the intact free @entity3 -low density lipoprotein complex. @entity3 uptake increased as the ratio of free @entity3 to low density lipoprotein was raised. When albumin was added to the medium, free @entity3 uptake decreased. A large percentage of the newly incorporated cellular radioactivity was released into the medium if the cells were exposed subsequently to a solution containing albumin. Most of the released radioactivity was in the form of free @entity3 . The results with this experimental model suggest that lipoprotein-bound free @entity3 , like albumin-bound free @entity3 , is readily available for uptake by isolated cells. The mechanism of free @entity3 utilization by the Ehrlich cell is similar when either low density lipoprotein or serum albumin serves as the @entity3 carrier.

title: Utilization of free @entity4 complexed to @entity0 plasma lipoproteins by XXXX cell suspensions.

answer: @entity0


abstract: BACKGROUND: Spatially explicit forest @entity1 (C) monitoring aids conservation and climate change mitigation efforts, yet few approaches have been developed specifically for the highly heterogeneous landscapes of oceanic island chains that continue to undergo rapid and extensive forest C change. We developed an approach for rapid mapping of @entity2 ( @entity2 ; units  =  @entity3 or metric tons  C  ha(-1)) on islands at a spatial resolution of 30  m (0.09  ha) using a combination of cost-effective airborne LiDAR data and full-coverage satellite data. We used the approach to map forest @entity2 across the main Hawaiian Islands, comparing C stocks within and among islands, in protected and unprotected areas, and among forests dominated by native and invasive species. RESULTS: Total forest aboveground C stock of the Hawaiian Islands was 36 Tg, and @entity2 distributions were extremely heterogeneous both within and across islands. Remotely sensed @entity2 was validated against U.S. Forest Service FIA plot inventory data (R(2)  =  0.67; RMSE  =  30.4  Mg  C  ha(-1)). Geospatial analyses indicated the critical importance of forest type and canopy cover as predictors of mapped @entity2 patterns. Protection status was a strong determinant of forest C stock and density, but we found complex environmentally mediated responses of forest @entity2 to @entity0 . CONCLUSIONS: A combination of one-time airborne LiDAR data acquisition and satellite monitoring provides effective forest C mapping in the highly heterogeneous landscapes of the Hawaiian Islands. Our statistical approach yielded key insights into the drivers of @entity2 variation, and also makes possible future assessments of C storage change, derived on a repeat basis from free satellite data, without the need for additional LiDAR data. Changes in C stocks and densities of oceanic islands can thus be continually assessed in the face of rapid environmental changes such as biological invasions, drought, fire and land use. Such forest monitoring information can be used to promote sustainable forest use and conservation on islands in the future.

title: Rapid forest XXXX assessments of oceanic islands: a case study of the Hawaiian archipelago.

answer: @entity1


abstract: Two experiments were conducted to investigate @entity3 addition to reduced crude protein @entity4 - @entity0 meal (C-SBM) diets with varying levels of TSAA achieved by varying Met and @entity2 . The experiments were conducted with female Ross 708 broilers in brooder batteries from 0 to 18 d posthatching. Treatments had 6 replicates with 6 broilers/pen. Diets in all experiments were fed without or with @entity3 supplementation to contain 2.32% total @entity3 + Ser. All diets were C-SBM based and formulated to contained 1.27% standardized ileal digestible Lys supplemented with 0.20% Lys (0.394% Lys  SO(4)) and to meet or exceed the requirement of all nutrients except Met and @entity2 where appropriate. Experiment 1 consisted of 8 dietary treatments. Three ratios of Met to @entity2 (60:40, 50:50, and 40:60) were used on a mole for mole basis to achieve 0.063 mol of TSAA/kg of feed and a positive control with Met: @entity2 of 50:50 at 0.76 TSAA:Lys. @entity1 supplementation did not affect ADG or ADFI; however, G:F was increased (P = 0.003) with @entity3 supplementation. An increase in @entity2 and a decrease in Met resulted in a decrease (P = 0.028) in ADG but had no effect on ADFI or G:F. In experiment 2, Met was kept constant at a marginal level of 0.45% and @entity2 was increased in 0.05% increments from 0.35 to 0.50%. @entity1 supplementation had no main effect on ADG, ADFI, or G:F; however, @entity3 increased G:F at the lower levels of @entity2 but not at the higher levels ( @entity3   @entity2 , P = 0.031). A linear decrease (P = 0.071) was found in ADFI with increasing @entity2 supplementation. These data indicate that @entity3 increased G:F in female broilers fed suboptimal levels of Met and @entity2 but not at @entity2 levels at or above the requirement. This implies that the synthesis of @entity2 accounts for a portion of the increased G:F observed from @entity3 supplementation in female broilers fed reduced CP C-SBM diets.

title: Effects of XXXX supplementation at varying levels of methionine and cystine on the growth performance of broilers fed reduced crude protein diets.

answer: @entity1


abstract: This is to describe a case of a morbidly @entity2 (BMI  =  40) female with @entity4 treated with laparoendoscopic single-site surgery. A JJ stent was positioned. A 2  cm umbilical access was created. A single port platform was positioned. The entire ureter was mobilized posterior to the vena cava and transected where the dilated portion ended. The distal ureter was repositioned lateral to the inferior vena cava. @entity3 was done. A 3  mm trocar was used to assist suturing. At 4-month follow-up, CT revealed no evidence of @entity1 and the @entity0 was symptomless. Although challenging, in a morbidly @entity2 @entity0 , LESS repair for @entity4 is feasible.

title: Laparoscopic Single Site Surgery for Repair of XXXX in a Morbidly Obese @entity0 .

answer: @entity4


abstract: This is to describe a case of a morbidly @entity2 (BMI  =  40) female with @entity4 treated with laparoendoscopic single-site surgery. A JJ stent was positioned. A 2  cm umbilical access was created. A single port platform was positioned. The entire ureter was mobilized posterior to the vena cava and transected where the dilated portion ended. The distal ureter was repositioned lateral to the inferior vena cava. @entity3 was done. A 3  mm trocar was used to assist suturing. At 4-month follow-up, CT revealed no evidence of @entity1 and the @entity0 was symptomless. Although challenging, in a morbidly @entity2 @entity0 , LESS repair for @entity4 is feasible.

title: Laparoscopic Single Site Surgery for Repair of @entity4 in a Morbidly Obese XXXX .

answer: @entity0


abstract: BACKGROUND: Inflammation and @entity1 induced by delayed onset @entity4 (DOMS) as a result of eccentric exercise (EE) or unaccustomed activity cause some difficulties in exercise for athletes. The purpose of this study was to survey the effect of ginger extract on biochemical and functional symptom of delayed onset @entity4 . METHODS: In a quasi-experimental study, 36 healthy female subjects, who were recruited by intra dormitory calls, randomly divided into 3 groups, including: ginger intake 1 hour before exercise (GIBE), ginger intake immediately after exercise (GIAE) and placebo group (PL). Subjects consumed capsules contain 60 mg of ginger extract (equivalent of 2 g dried ginger powder) or placebo before and after exercise. The exercise protocol consisted of a 20 minute step test using a 46cm step at a rate of 15 steps per minute. The blood samples were taken before, 1, 24 and 48 hour after exercise to assay @entity3 kinase (CK) and @entity2 ( @entity2 ). @entity4 scores, isometric strength and circumference of thigh muscle, and hip range of motion were recorded at mentioned times. The analysis of variance (ANOVA) with repeated measure was used to determine the differences between groups. RESULTS: The results showed a significant @entity1 in GIBE compared to GIAE after 24 and 48h of EE and GIAE compared to PL (p<0.05). @entity2 changed significantly in GIBE compared to PL (p<0.05) after 1, 24, and 48h after EE. The other factors didn't change meaningfully. CONCLUSION: The finding of this study suggests that 2 grams of ginger may have anti- @entity0 and analgesic effect on DOMS.

title: Acute effects of ginger extract on biochemical and functional symptoms of delayed onset XXXX .

answer: @entity4


abstract: Inhibition of intercellular junctional communication by @entity3 ( @entity4 ) and @entity6 was investigated using a @entity7 incorporation assay. This new assay uses metabolic co-operation between @entity9 -deficient @entity0 fibroblasts and arginosuccinate synthetase-deficient cells as a measure of junctional communication. Short-term exposure to @entity4 resulted in virtually complete inhibition of metabolic co-operation when V79 cells were used as the synthetase-deficient type. When synthetase-deficient @entity0 fibroblasts were used, inhibition by @entity4 was only partial. Exposure to high concentrations of @entity4 for prolonged periods resulted in partial reversal of communication inhibition and a refractory state in which cells were unresponsive to @entity4 . @entity5 and other @entity6 also inhibited metabolic co-operation, but did not cause desensitisation of the type seen with @entity4 after prolonged exposure. Cultures which had been made refractory to @entity4 remained sensitive to inhibition by @entity5 and @entity2 , indicating that these latter compounds inhibit junctional communication by a mechanism different from @entity4 . Simultaneous exposure of cultures to @entity4 and @entity5 showed that the inhibitory effects on metabolic co-operation of these compounds were additive. @entity8 did not antagonise the effect of @entity4 . These results suggest that @entity5 and @entity8 exert their anti- @entity1 -promoting action by mechanisms which are not mediated by intercellular junctional communication.

title: Effects of XXXX and @entity6 on intercellular junctional communication measured with a @entity7 incorporation assay.

answer: @entity3


abstract: Inhibition of intercellular junctional communication by @entity3 ( @entity4 ) and @entity6 was investigated using a @entity7 incorporation assay. This new assay uses metabolic co-operation between @entity9 -deficient @entity0 fibroblasts and arginosuccinate synthetase-deficient cells as a measure of junctional communication. Short-term exposure to @entity4 resulted in virtually complete inhibition of metabolic co-operation when V79 cells were used as the synthetase-deficient type. When synthetase-deficient @entity0 fibroblasts were used, inhibition by @entity4 was only partial. Exposure to high concentrations of @entity4 for prolonged periods resulted in partial reversal of communication inhibition and a refractory state in which cells were unresponsive to @entity4 . @entity5 and other @entity6 also inhibited metabolic co-operation, but did not cause desensitisation of the type seen with @entity4 after prolonged exposure. Cultures which had been made refractory to @entity4 remained sensitive to inhibition by @entity5 and @entity2 , indicating that these latter compounds inhibit junctional communication by a mechanism different from @entity4 . Simultaneous exposure of cultures to @entity4 and @entity5 showed that the inhibitory effects on metabolic co-operation of these compounds were additive. @entity8 did not antagonise the effect of @entity4 . These results suggest that @entity5 and @entity8 exert their anti- @entity1 -promoting action by mechanisms which are not mediated by intercellular junctional communication.

title: Effects of @entity3 and @entity6 on intercellular junctional communication measured with a XXXX incorporation assay.

answer: @entity7


abstract: Inhibition of intercellular junctional communication by @entity3 ( @entity4 ) and @entity6 was investigated using a @entity7 incorporation assay. This new assay uses metabolic co-operation between @entity9 -deficient @entity0 fibroblasts and arginosuccinate synthetase-deficient cells as a measure of junctional communication. Short-term exposure to @entity4 resulted in virtually complete inhibition of metabolic co-operation when V79 cells were used as the synthetase-deficient type. When synthetase-deficient @entity0 fibroblasts were used, inhibition by @entity4 was only partial. Exposure to high concentrations of @entity4 for prolonged periods resulted in partial reversal of communication inhibition and a refractory state in which cells were unresponsive to @entity4 . @entity5 and other @entity6 also inhibited metabolic co-operation, but did not cause desensitisation of the type seen with @entity4 after prolonged exposure. Cultures which had been made refractory to @entity4 remained sensitive to inhibition by @entity5 and @entity2 , indicating that these latter compounds inhibit junctional communication by a mechanism different from @entity4 . Simultaneous exposure of cultures to @entity4 and @entity5 showed that the inhibitory effects on metabolic co-operation of these compounds were additive. @entity8 did not antagonise the effect of @entity4 . These results suggest that @entity5 and @entity8 exert their anti- @entity1 -promoting action by mechanisms which are not mediated by intercellular junctional communication.

title: Effects of @entity3 and XXXX on intercellular junctional communication measured with a @entity7 incorporation assay.

answer: @entity6


abstract: BACKGROUND: @entity1 survivors are commonly left with disabilities that impair activities of daily living. The main objective of their rehabilitation program is to maximize the functional performance at home. However, the actual performance of @entity0 in their home environment is unknown. Therefore, objective evaluation of daily life activities of @entity1 survivors in their physical interaction with the environment is essential for optimal guidance of rehabilitation therapy. Monitoring daily life movements could be very challenging, as it may result in large amounts of data, without any context. Therefore, suitable metrics are necessary to quantify relevant aspects of movement performance during daily life. The objective of this study is to develop data processing methods, which can be used to process movement data into relevant metrics for the evaluation of intra- @entity0 differences in quality of movements in a daily life setting. METHODS: Based on an iterative requirement process, functional and technical requirements were formulated. These were prioritized resulting in a coherent set of metrics. An activity monitor was developed to give context to captured movement data at home. Finally, the metrics will be demonstrated in two @entity1 @entity0 during and after their rehabilitation phases. RESULTS: By using the final set of metrics, quality of movement can be evaluated in a daily life setting. As example to demonstrate potential of presented methods, data of two @entity1 @entity0 were successfully analyzed. Differences between in-clinic measurements and measurements during daily life are observed by applying the presented metrics and visualization methods. Heel height profiles show intra- @entity0 differences in height, distance, stride profile, and variability between strides during a 10-m walk test in the clinic and walking at home. Differences in distance and stride profile between both feet were larger at home, than in clinic. For the upper extremities, the @entity0 was able to reach further away from the pelvis and cover a larger area. DISCUSSION: Presented methods can be used for the objective evaluation of intra- @entity0 differences in movement quality between in-clinic and daily life measurements. Any observed progression or deterioration of movement quality could be used to decide on continuing, stopping, or adjusting rehabilitation programs.

title: Objective Evaluation of the Quality of Movement in Daily Life after XXXX .

answer: @entity1


abstract: @entity2 repair has been associated with changes in arterial stiffness, as estimated by pulse wave velocity ( @entity1 ). This marker is influenced by the medical status of the @entity0 , the elastic characteristics of the @entity2 wall, and the presence of intraluminal @entity3 . Therefore, in order to delineate the influence of the endograft implantation in the early post-operative period, we conducted non-invasively pulse wave analysis in a male @entity0 with an @entity4 containing no intraluminal @entity3 , unremarkable past medical history, and absence of @entity5 . The estimated parameters were the systolic and diastolic pressure calculated at the aortic level (central pressures), @entity1 , augmentation pressure (AP) and augmentation index (AI), pressure wave reflection magnitude (RM), and peripheral resistance. Central systolic and diastolic pressure decreased post-operatively. @entity1 showed subtle changes from 11.6 to 10.6 and 10.9   m/s at 1-week and 1-month, respectively. Accordingly, the AI decreased from 28 to 14% and continued to drop to 25%. The AP decreased gradually from 15 to 6 and 4   mmHg. The wave RM dropped from 68 to 52% at 1-month. Finally, the peripheral resistance dropped from 1.41 to 0.99 and 0.85   dyn   *   s   *   cm(-5). Our example shows that the implantation of an aortic endograft can modify the pressure wave reflection over the aortic bifurcation without causing significant alterations in @entity1 .

title: Non-Invasive Pulse Wave Analysis in a XXXX after Implantation of a Nitinol Aortic Endograft.

answer: @entity4


abstract: @entity8 is confined in tropical and subtropical regions, which can cause life-threatening disease. It is the only @entity8 species that is pathogenic to @entity0 . Because of its rarity, clinicians often do not appreciate its importance when it is isolated. We report a fulminate fatal case of @entity9 @entity7 in a 20-year-old male Taiwanese. The clinical manifestations were @entity1 and @entity3 , followed by @entity5 . Emergent laparotomy identified @entity4 with @entity2 . Flomoxef @entity6 was administered immediately. However, his condition deteriorated rapidly and he died within 48 h after the onset of illness. Two sets of blood culture yielded @entity9 . Physicians should be aware of the occurrence of this infection in summer season.

title: @entity8 XXXX : a case report.

answer: @entity7


abstract: @entity8 is confined in tropical and subtropical regions, which can cause life-threatening disease. It is the only @entity8 species that is pathogenic to @entity0 . Because of its rarity, clinicians often do not appreciate its importance when it is isolated. We report a fulminate fatal case of @entity9 @entity7 in a 20-year-old male Taiwanese. The clinical manifestations were @entity1 and @entity3 , followed by @entity5 . Emergent laparotomy identified @entity4 with @entity2 . Flomoxef @entity6 was administered immediately. However, his condition deteriorated rapidly and he died within 48 h after the onset of illness. Two sets of blood culture yielded @entity9 . Physicians should be aware of the occurrence of this infection in summer season.

title: XXXX @entity7 : a case report.

answer: @entity8


abstract: OBJECTIVE: To study the effect of denervating duration on the surgical outcome of laryngeal reinnervation in @entity0 with unilateral vocal fold paralysis (UVFP). METHODS: The charts of 467 consecutive @entity0 with UVFP were reviewed retrospectively. Preoperative and postoperative data, including videostroboscopy, perceptual evaluation of voice (GRBAS scale), acoustic analysis, maximum phonation time (MPT) and laryngeal reinnervation were collected. Multivariable logistic regression analysis was used to identify possible influential factors including the age of @entity0 , gender, degree of @entity1 and duration of @entity1 . Then stratification analysis was performed on the variable-duration of @entity1 , to study how the duration of @entity1 could affect the surgical outcome of laryngeal reinnervation. RESULTS: Multivariable logistic regression analysis showed that the age of @entity0 , degree of @entity1 and duration of @entity1 were significant variables. Stratification analysis on duration of @entity1 demonstrated that in each subgroup postoperative data were significantly improved. When compared among the three subgroups, postoperative data in group with a duration of 6-12 months and group with a duration 12-24 months were significantly better than group with a duration more than 24 months. However, there were no significant differences between group with a duration of 6-12 months and 12-24 months. CONCLUSION: Surgical outcome of laryngeal reinnervation is better in @entity0 those with a duration of @entity1 less than 2 years than in those with a duration of @entity1 more than 2 years.

title: [Effect of denervating duration on the surgical outcome of laryngeal reinnervation in XXXX with unilateral vocal fold paralysis].

answer: @entity0


abstract: Denosumab is a fully human monoclonal antibody that inhibits RANKL, a protein essential for osteoclast formation, function, and survival. Osteoclast inhibition with denosumab decreased bone resorption, increased @entity1 ( @entity1 ), and reduced @entity2 risk in @entity3 @entity0 . The effects of 16months of continuous osteoclast inhibition on bone strength parameters were examined in adult ovariectomized (OVX) @entity4 (cynos). One month after surgery, OVX cynos (n=14-20/group) were treated monthly with subcutaneous vehicle (OVX-Veh) or denosumab (25 or 50mg/kg). Sham-operated controls were treated with vehicle (n=17). OVX-Veh exhibited early and persistent increases in the resorption marker CTx, followed by similar increases in the formation marker BSAP, consistent with @entity1 . Denosumab reduced CTx and BSAP throughout the study to levels significantly lower than in OVX-Veh or Sham-Veh, consistent with reduced remodeling. Increased remodeling in OVX-Veh led to absolute declines in areal @entity1 of 4.3-7.4% at the lumbar spine, total hip, femur neck, and distal radius (all p<0.05 vs baseline). Denosumab significantly increased aBMD at each site to levels exceeding baseline or OVX-Veh controls, and denosumab significantly increased cortical vBMC of the central radius and tibia by 7% and 14% (respectively) relative to OVX-Veh. Destructive biomechanical testing revealed that both doses of denosumab were associated with significantly greater peak load for femur neck (+19-34%), L3-L4 vertebral bodies (+54-55%), and L5-L6 cancellous cores (+69-82%) compared with OVX-Veh. Direct assessment of bone tissue material properties at cortical sites revealed no significant changes with denosumab. For all sites analyzed biomechanically, bone mass (BMC) and strength (load) exhibited strong linear correlations (r(2)=0.59-0.85 for all groups combined). Denosumab did not alter slopes of load-BMC regressions at any site, and denosumab groups exhibited similar or greater load values at given BMC values compared with OVX-Veh or Sham. In summary, denosumab markedly reduced biochemical markers of bone remodeling and increased cortical and trabecular bone mass in adult OVX cynos. Denosumab improved structural bone strength parameters at all sites analyzed, and strength remained highly correlated with bone mass. There was no evidence for reduced material strength properties of cortical bone with denosumab over this time period, which approximates to 4years of remodeling in the slower-remodeling adult @entity0 skeleton. These data indicate that denosumab increased bone strength by increasing bone mass and preserving bone quality.

title: Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized XXXX .

answer: @entity4


abstract: OBJECTIVES: MET amplification, protein expression, and splice mutations at exon 14 are known to cause dysregulation of the MET/ @entity4 pathway. Our study aimed to confirm the relationship among MET amplification, protein expression, and mutations in @entity2 . MATERIALS AND METHODS: MET protein expression by immunohistochemistry (IHC) and MET amplification by fluorescence in situ hybridization (FISH) were evaluated in 316 surgically resected @entity3 . @entity0 were divided into 4 groups (IHC-negative/FISH-negative, IHC-negative/FISH-positive, IHC-positive/FISH-negative, and IHC-positive/FISH-positive), and 15-20 @entity1 in each group were randomly selected for mutation analyses to find splice mutations at exon 14. RESULTS: An IHC score of 0-3 was found in 168 (53.2%), 71 (22.5%), 59 (18.7%), and 18 (5.7%) @entity1 , respectively. The mean gene copy number (GCN) was 3.56; MET FISH positivity was detected in 123 (38.9%) samples, and 26 (8.2%) of them were gene amplifications. MET amplification were significantly associated with the IHC score (P<0.001,   (2) test). Splice mutations were identified in only 2 (2.9%) of 70 cases. One had a MET IHC score of 2 and negative FISH without amplification; The other had a MET IHC score of 0 and positive FISH without amplification. MET IHC or FISH results were not prognostic indicators of overall survival in multivariate analysis. CONCLUSION: There is a significant relationship between MET amplification and protein expression, and selection of @entity1 with amplification using IHC was effective. However, because of its rarity, a selection strategy for mutated @entity1 is implausible using IHC or FISH.

title: MET amplification, protein expression, and mutations in XXXX .

answer: @entity2


abstract: The purpose of this pilot study is to evaluate the effectiveness of the Lifestyle Change Program (LSCP). LSCP was a holistic cardiac rehabilitation (CR) intervention focusing on several psychosocial and biological predictors of @entity3 including @entity4 , hostility, low social support, high perceived stress, low spirituality, low life satisfaction, overall health status and @entity1 levels. Utilising a quasi-experimental design, overall health scores of LSCP @entity0 were compared with those of a control group. To assess differences within-and between- groups, two (programme type)   2 (age)   2 (gender)   2 (time) mixed design ANOVAs were used. Within-group relationships for psychosocial assessments and @entity1 levels were analysed using paired-samples t-tests. Results suggest that there were no significant differences between the LSCP group and the control group with regard to overall health status. However, the LSCP @entity0 reported significantly lower levels of @entity4 and perceived stress, as well as significantly higher levels of life satisfaction and spirituality upon programme completion. In addition, lipid panels changed significantly: A significant decrease in total @entity1 , low-density lipoproteins and @entity5 , as well as a significant increase in high-density lipoproteins. These trends suggest that holistic CR may be effective at reducing biopsychosocial risk factors for future @entity2 . Future studies, utilising an experimental design, are necessary to determine whether holistic programmes are more effective than traditional programmes in the reduction of cardiac risk factors.

title: Evaluation of a holistic cardiac rehabilitation in the reduction of biopsychosocial risk factors among @entity0 with XXXX .

answer: @entity3


abstract: The purpose of this pilot study is to evaluate the effectiveness of the Lifestyle Change Program (LSCP). LSCP was a holistic cardiac rehabilitation (CR) intervention focusing on several psychosocial and biological predictors of @entity3 including @entity4 , hostility, low social support, high perceived stress, low spirituality, low life satisfaction, overall health status and @entity1 levels. Utilising a quasi-experimental design, overall health scores of LSCP @entity0 were compared with those of a control group. To assess differences within-and between- groups, two (programme type)   2 (age)   2 (gender)   2 (time) mixed design ANOVAs were used. Within-group relationships for psychosocial assessments and @entity1 levels were analysed using paired-samples t-tests. Results suggest that there were no significant differences between the LSCP group and the control group with regard to overall health status. However, the LSCP @entity0 reported significantly lower levels of @entity4 and perceived stress, as well as significantly higher levels of life satisfaction and spirituality upon programme completion. In addition, lipid panels changed significantly: A significant decrease in total @entity1 , low-density lipoproteins and @entity5 , as well as a significant increase in high-density lipoproteins. These trends suggest that holistic CR may be effective at reducing biopsychosocial risk factors for future @entity2 . Future studies, utilising an experimental design, are necessary to determine whether holistic programmes are more effective than traditional programmes in the reduction of cardiac risk factors.

title: Evaluation of a holistic cardiac rehabilitation in the reduction of biopsychosocial risk factors among XXXX with @entity3 .

answer: @entity0


abstract: @entity2 in the locus coeruleus (LC) has been documented in several central nervous system (CNS) @entity2 . In the present study, @entity1 -induced oxidative injury in the LC was investigated in @entity8 anesthetized @entity0 . Three days after bilateral infusion of @entity1 in the LC, both vertical and horizontal locomotor activities were decreased. Seven days after unilateral infusion of @entity1 , lipid peroxidation was elevated in the infused LC, and the @entity4 content was depleted in the ipsilateral hippocampus of the brain. Furthermore, the immunohistochemical study demonstrated a reduction in @entity3 hydroxylase-positive neurons in the infused LC. The involvement of programmed cell death (apoptosis) in @entity1 -induced oxidative injury in the LC was investigated. Forty-eight hours after @entity1 infusion, cytosolic cytochrome c was elevated in the infused LC. Moreover, terminal deoxytransferase-mediated @entity5 -nick end labeling (TUNEL)-positive cells, an indicative of apoptosis, were detected in the infused LC. In an attempt to prevent oxidative injury in the LC, @entity6 was systemically administered. Intraperitoneal injection of @entity6 attenuated @entity1 -induced behavioral changes in locomotor activity as well as @entity1 -induced increases in cytosolic cytochrome c and TUNEL-positive cells. Moreover, @entity6 diminished @entity1 -induced oxidative injury. At the same time, the level of @entity7 ( @entity7 ) was elevated in the LC of @entity6 -treated @entity0 . Our data suggests that oxidative stress because of @entity1 results in apoptosis in the infused LC and causes degeneration of the coeruleohippocampal noradrenergic system in the @entity0 brain. Furthermore, @entity6 , among other mechanisms, may exert its neuroprotection via up-regulation of @entity7 levels in CNS.

title: Oxidative injury to the locus coeruleus of @entity0 brain: neuroprotection by XXXX .

answer: @entity6


abstract: @entity2 in the locus coeruleus (LC) has been documented in several central nervous system (CNS) @entity2 . In the present study, @entity1 -induced oxidative injury in the LC was investigated in @entity8 anesthetized @entity0 . Three days after bilateral infusion of @entity1 in the LC, both vertical and horizontal locomotor activities were decreased. Seven days after unilateral infusion of @entity1 , lipid peroxidation was elevated in the infused LC, and the @entity4 content was depleted in the ipsilateral hippocampus of the brain. Furthermore, the immunohistochemical study demonstrated a reduction in @entity3 hydroxylase-positive neurons in the infused LC. The involvement of programmed cell death (apoptosis) in @entity1 -induced oxidative injury in the LC was investigated. Forty-eight hours after @entity1 infusion, cytosolic cytochrome c was elevated in the infused LC. Moreover, terminal deoxytransferase-mediated @entity5 -nick end labeling (TUNEL)-positive cells, an indicative of apoptosis, were detected in the infused LC. In an attempt to prevent oxidative injury in the LC, @entity6 was systemically administered. Intraperitoneal injection of @entity6 attenuated @entity1 -induced behavioral changes in locomotor activity as well as @entity1 -induced increases in cytosolic cytochrome c and TUNEL-positive cells. Moreover, @entity6 diminished @entity1 -induced oxidative injury. At the same time, the level of @entity7 ( @entity7 ) was elevated in the LC of @entity6 -treated @entity0 . Our data suggests that oxidative stress because of @entity1 results in apoptosis in the infused LC and causes degeneration of the coeruleohippocampal noradrenergic system in the @entity0 brain. Furthermore, @entity6 , among other mechanisms, may exert its neuroprotection via up-regulation of @entity7 levels in CNS.

title: Oxidative injury to the locus coeruleus of XXXX brain: neuroprotection by @entity6 .

answer: @entity0


abstract: OBJECTIVES: To document the prevalence of self- and informant report of cognitive problems, usually referred to as "subjective @entity1 " (SCCs), in a community-dwelling sample of older adults and to examine the relationship between @entity1 , mood, and personality measures. @entity0 : Eight hundred twenty-seven nondemented community-dwelling adults aged 70-90 years. MEASUREMENTS: @entity0 were asked 24 @entity6 questions, including the Memory Complaint Questionnaire (MAC-Q), and completed neuropsychological testing in the domains of memory, language, executive function, visuospatial skills, and psychomotor speed. The Geriatric Depression Scale, Goldberg Anxiety Scale, and @entity4 , Openness, and Conscientiousness from the NEO-Five Factor Inventory were used as measures of @entity0 ' psychological status. Informants completed 19 @entity6 questions, including a modified short Informant Questionnaire on @entity1 in the Elderly (IQCODE). RESULTS: Overall, 95.5% of @entity0 or their informants endorsed at least one @entity6 . Although @entity0 were more likely to endorse a memory complaint, informants seemed more accurate in endorsing a complaint when @entity1 was objectively present. @entity6 correlated with @entity0 ' scores on measures of @entity3 , @entity2 , @entity4 , and inversely with measures of @entity5 and conscientiousness. Age, education, and sex had little impact on these effects. Regression analysis showed that psychological factors explained the number of complaints more than cognitive performance. CONCLUSIONS: The usefulness of SCCs as a criterion for mild @entity1 is questioned because of their high prevalence and their relationship to psychological factors. This may be helpful for clinicians to bear in mind when presented with @entity0 with @entity1 .

title: Prevalence and predictors of    subjective XXXX    in the Sydney Memory and Ageing Study.

answer: @entity1


abstract: Theory of mind (ToM), the specific ability to attribute thoughts and feelings to oneself and others is generally impaired in @entity2 . Previous studies demonstrated a deficit of the attribution of intentions to others among @entity0 having @entity1 . During nonverbal tasks, such a function requires both the visual perception of @entity0 figures and the understanding of their intentions. These processes are considered to involve the superior temporal sulcus and the medial prefrontal cortex, respectively. Are the functional patterns of activation associated with those processes abnormal in @entity2 ? Seven @entity2 @entity0 on medication performed a nonverbal attribution of intentions task as well as two matched physical logic tasks, with and without @entity0 figures, while @entity3 15 PET-scanning was performed. Data from the @entity0 were compared to those of eight healthy controls matched for verbal IQ and sex. The experimental design allowed dissociating the effect of the perception of @entity0 figures from that of the attribution of intentions. During attribution of intentions, significant activations in the right prefrontal cortex were detected in the control subjects. Those activations were not found in the @entity2 group. However, in both groups, the perception of @entity0 figure elicited bilateral activation of the occipitotemporal regions and of the posterior part of the superior temporal sulcus. @entity2 @entity0 performing a nonverbal attribution of intentions task have an abnormal cerebral activity.

title: Abnormalities of brain function during a nonverbal theory of mind task in XXXX .

answer: @entity2


abstract: PURPOSE: We report initial data on the safety and functional outcomes of @entity2 with arterial cold perfusion during partial nephrectomy. MATERIALS AND METHODS: From June 2007 to June 2009, 31 consecutive @entity0 underwent laparoscopic partial nephrectomy with @entity7 using renal arterial perfusion with cold, lactated Ringer's solution during @entity2 . Doppler echography was done intraoperatively to evaluate renal perfusion. Complication data were reported prospectively. Median followup was 57 weeks (IQR 28, 83). RESULTS: The lowest recorded renal temperature during @entity3 was 14C. Median @entity1 size was 4.0 cm (IQR 2.7, 6.2). Median estimated @entity5 was 150 cc (IQR 100, 275). Median @entity3 time was 35 minutes (IQR 26, 41). Doppler echography identified intrarenal arterial blood flow postoperatively in all cases. The median change in the estimated glomerular filtration rate from preoperatively to postoperative day 2 was 4 ml per minute (IQR -29, 19). Two months postoperative in 20 @entity0 the median change was 3.5 ml per minute (IQR -6, 16.5). At last followup in 31 @entity0 the overall change in the estimated glomerular filtration rate was -0.5 ml per minute (IQR -6, 6). Six complications developed in a total of 5 @entity0 , of which 5 were grade 2 or less. One grade 3 @entity4 from an arteriovenous fistula at the @entity1 resection site was treated with angiography and selective embolization. CONCLUSIONS: Cold intravascular perfusion during laparoscopic partial nephrectomy can achieve @entity2 below 15C. It is not associated with an immediate risk of @entity2 or @entity6 , as measured by Doppler echography in this series. Early changes in postoperative estimates of renal function appear minimal.

title: Cold intravascular organ perfusion for XXXX during laparoscopic partial nephrectomy.

answer: @entity2


abstract: @entity2 to renal arteries often receives suboptimal management because of delayed diagnosis, incomplete preoperative evaluation, associated injuries, or unknown functional capacity of the contralateral kidney. We propose a rational treatment plan from an analysis of our three cases and a review of 118 cases. Two thirds of the @entity0 were male, and left-sided injuries predominated over right 42.9% to 30.6%. In 20 cases the insult was bilateral. @entity6 occurred in 72%, averaging 1.6 injuries per case, of which one half were intra-abdominal. Flank and/or @entity3 was present in 73% of cases, @entity5 in 65%, and gross or microscopic @entity4 in 74%. Repairs were attempted on 38 renal arteries. "Successful" repairs were accomplished in 16 arteries, while repairs failed in 22. Subsequent @entity1 developed in 32% of successes. Repair should be attempted in stable @entity0 with unilateral injury of less than four hours' duration, bilateral injuries of less than 20 hours' duration, or injuries with nonocclusion on arteriogram.

title: Proper management of renal artery injury from blunt XXXX .

answer: @entity2


abstract: BACKGROUND: In recent decades, there have been substantial changes in mortality from @entity1 in Europe. OBJECTIVE: To provide updated information, we analyzed trends in mortality from @entity3 , testis, bladder, and kidney in Europe from 1970 to 2008. DESIGN, SETTING, AND @entity0 : We derived data for 33 European countries from the World Health Organization database. MEASUREMENTS: We computed world-standardized mortality rates and used joinpoint regression to identify significant changes in trends. RESULTS AND LIMITATIONS: Mortality from @entity3 has leveled off since the 1990s in countries of western and northern Europe, particularly over the last few years while it was still rising in Bulgaria, Romania, and Russia. In the European Union (EU), it reached a peak in 1995 at 15.0 per 100 000 @entity0 and declined to 12.5 per 100 000 in 2006. Mortality from @entity1 has steadily declined in most countries in western and northern Europe since the 1970s. The declines were later and appreciably lower in central/eastern Europe. In EU, rates declined from 0.75 in 1980 to 0.32 per 100 000 @entity0 in 2006, with stronger declines up to the late 1990s and an apparent leveling off in rates thereafter. Over the last 15 years, mortality from @entity2 has declined in most European countries in both sexes. The major exceptions were Bulgaria, Poland, and Romania. In the EU, @entity2 mortality was stable until 1992 and declined thereafter from 7.3 to 5.5 per 100 000 @entity0 and from 1.5 to 1.2 per 100 000 @entity0 in 2006. Mortality from @entity4 increased throughout Europe until the early 1990s and leveled off thereafter in many countries, except in a few central and eastern ones. Between 1994 and 2006, rates declined from 4.9 to 4.3 per 100 000 in EU @entity0 and from 2.1 to 1.8 per 100 000 in EU @entity0 . CONCLUSIONS: Over the last two decades, trends in @entity1 mortality were favorable in Europe, with the exception of a few central and eastern countries.

title: Trends in mortality from XXXX in Europe, 1970-2008.

answer: @entity1


abstract: BACKGROUND: @entity6 with ejection fraction (HFpEF) is a syndrome resulting from several co-morbidities in which specific mediators are unknown. The platelet proteome responds to disease processes. We hypothesize that the platelet proteome will change composition in @entity0 with HFpEF and may uncover mediators of the syndrome. METHODS AND RESULTS: Proteomic changes were assessed in platelets from hospitalized subjects with symptoms of HFpEF (n  =  9), the same subjects several weeks later without symptoms (n  =  7) and control subjects (n  =  8). Mass spectrometry identified 6102 proteins with five scans with peptide probabilities of >= 0.85. Of the 6102 proteins, 165 were present only in symptomatic subjects, 78 were only found in outpatient subjects and 157 proteins were unique to the control group. The @entity8 protein was identified consistently in HFpEF samples when compared with controls. We validated the fining that plasma @entity8 levels are increased in subjects with HFpEF (654      391) compared to controls (352      204) in an external cohort (p  =  0.002). Recombinant @entity8 had direct effects on the electrophysiological and @entity4 handling profile in @entity0 induced pluripotent stem cell-derived cardiomyocytes. CONCLUSIONS: Platelets may harbor proteins associated with HFpEF. @entity8 is present in the platelets of subjects with HFpEF and increased in the plasma of the same subjects. We further established a bedside-to-bench translational system that can be utilized as a secondary screen to ascertain whether the biomarkers may be an associated finding or causal to the disease process. @entity8 has been linked with other @entity2 such as @entity7 and risk for @entity5 , @entity1 , or @entity3 . This is the first report on association of @entity8 with HFpEF.

title: Combining @entity0 proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of XXXX with preserved ejection fraction.

answer: @entity6


abstract: BACKGROUND: @entity6 with ejection fraction (HFpEF) is a syndrome resulting from several co-morbidities in which specific mediators are unknown. The platelet proteome responds to disease processes. We hypothesize that the platelet proteome will change composition in @entity0 with HFpEF and may uncover mediators of the syndrome. METHODS AND RESULTS: Proteomic changes were assessed in platelets from hospitalized subjects with symptoms of HFpEF (n  =  9), the same subjects several weeks later without symptoms (n  =  7) and control subjects (n  =  8). Mass spectrometry identified 6102 proteins with five scans with peptide probabilities of >= 0.85. Of the 6102 proteins, 165 were present only in symptomatic subjects, 78 were only found in outpatient subjects and 157 proteins were unique to the control group. The @entity8 protein was identified consistently in HFpEF samples when compared with controls. We validated the fining that plasma @entity8 levels are increased in subjects with HFpEF (654      391) compared to controls (352      204) in an external cohort (p  =  0.002). Recombinant @entity8 had direct effects on the electrophysiological and @entity4 handling profile in @entity0 induced pluripotent stem cell-derived cardiomyocytes. CONCLUSIONS: Platelets may harbor proteins associated with HFpEF. @entity8 is present in the platelets of subjects with HFpEF and increased in the plasma of the same subjects. We further established a bedside-to-bench translational system that can be utilized as a secondary screen to ascertain whether the biomarkers may be an associated finding or causal to the disease process. @entity8 has been linked with other @entity2 such as @entity7 and risk for @entity5 , @entity1 , or @entity3 . This is the first report on association of @entity8 with HFpEF.

title: Combining XXXX proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of @entity6 with preserved ejection fraction.

answer: @entity0