abstract: We evaluated the ability of spectral-domain optic coherence tomography (SD-OCT) to differentiate @entity5 ( @entity5 ) from glaucomatous cupping in eyes with intraocular pressure (IOP) within the normal range. We prospectively enrolled @entity0 with @entity3 or presumed @entity5 . @entity0 had optic discs with confirmed or suspected @entity1 (defined as a vertical cup-to-disc ratio>= 0.6), and all eyes had known untreated IOP<21 mmHg. For @entity4 , a reproducible glaucomatous @entity2 was required. @entity5 eyes required normal VF and no evidence of progressive @entity1 (follow-up>= 30 months). Peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell complex (GCC) thicknesses were obtained using SD-OCT. For all studied parameters of pRNFL and GCC thicknesses, eyes with @entity3 (n=36) had significantly thinner values compared to eyes with @entity5 (n=71; P<0.05 for all comparisons). In addition, pRNFL parameters had sensitivity of 66.7% and specificity of 83.1%, and GCC parameters had sensitivity of 61.2% and specificity of 81.7%. The combination of the two analyses increased the sensitivity to 80.6%. In conclusion, while evaluating @entity0 with large optic disc cupping and IOP in the statistically normal range, SD-OCT had only limited diagnostic ability to differentiate those with and without @entity3 . Although the diagnostic ability of the pRNFL and the GCC scans were similar, these parameters yielded an increase in sensitivity when combined, suggesting that both parameters could be considered simultaneously in these cases.

title: Eyes with large disc cupping and normal intraocular pressure: using optical coherence tomography to discriminate those with and without XXXX .

answer: @entity3


abstract: The Japanese Society of Thyroid Surgery undertook a pilot study of treatment for @entity9 in a cooperative setting. The treatment consisted of @entity4 40 mg/m2 drip intravenous infusion (div), day 1, @entity3 60 mg/m2 iv, day 1, etoposide 100 mg/m2/day div, days 1-3, @entity10 5 mg/body/day sc, days 1-5 and @entity5 ( @entity5 ) 2 micrograms/kg/day sc, days 6-14. This was scheduled to be repeated every 3 weeks. Local radiation therapy was added for @entity0 in whom it was indicated. A total of 17 @entity0 (mean age, 66 yr) were enrolled. Ten @entity0 had @entity8 with measurable lesions and 2 @entity0 experienced partial remission lasting 2 and 3 months, respectively. Six of 7 @entity0 were treated with the same modality of treatment as an adjuvant. Three died of progressive disease after 3-7 months and three others have survived for 3-11 months. The @entity1 of the chemotherapy were mainly bone marrow suppression, despite @entity5 support. Transient @entity2 was also noticed. These results indicate that this combined a treatment can be given to @entity0 with acceptable @entity1 . The degree of @entity7 was greater than expected, partly due to the advanced age of the @entity0 and the low dose of @entity5 . In addition, 8 available thyroid specimens were examined for the @entity6 gene and @entity6 , but all were negative. Further study of @entity9 by this cooperative group will be carried out.

title: Intensive chemotherapy for @entity9 : combination of XXXX , @entity3 , etoposide and @entity10 with granulocyte @entity5 support. Chemotherapy Committee, The Japanese Society of Thyroid Surgery.

answer: @entity4


abstract: The Japanese Society of Thyroid Surgery undertook a pilot study of treatment for @entity9 in a cooperative setting. The treatment consisted of @entity4 40 mg/m2 drip intravenous infusion (div), day 1, @entity3 60 mg/m2 iv, day 1, etoposide 100 mg/m2/day div, days 1-3, @entity10 5 mg/body/day sc, days 1-5 and @entity5 ( @entity5 ) 2 micrograms/kg/day sc, days 6-14. This was scheduled to be repeated every 3 weeks. Local radiation therapy was added for @entity0 in whom it was indicated. A total of 17 @entity0 (mean age, 66 yr) were enrolled. Ten @entity0 had @entity8 with measurable lesions and 2 @entity0 experienced partial remission lasting 2 and 3 months, respectively. Six of 7 @entity0 were treated with the same modality of treatment as an adjuvant. Three died of progressive disease after 3-7 months and three others have survived for 3-11 months. The @entity1 of the chemotherapy were mainly bone marrow suppression, despite @entity5 support. Transient @entity2 was also noticed. These results indicate that this combined a treatment can be given to @entity0 with acceptable @entity1 . The degree of @entity7 was greater than expected, partly due to the advanced age of the @entity0 and the low dose of @entity5 . In addition, 8 available thyroid specimens were examined for the @entity6 gene and @entity6 , but all were negative. Further study of @entity9 by this cooperative group will be carried out.

title: Intensive chemotherapy for XXXX : combination of @entity4 , @entity3 , etoposide and @entity10 with granulocyte @entity5 support. Chemotherapy Committee, The Japanese Society of Thyroid Surgery.

answer: @entity9


abstract: The Japanese Society of Thyroid Surgery undertook a pilot study of treatment for @entity9 in a cooperative setting. The treatment consisted of @entity4 40 mg/m2 drip intravenous infusion (div), day 1, @entity3 60 mg/m2 iv, day 1, etoposide 100 mg/m2/day div, days 1-3, @entity10 5 mg/body/day sc, days 1-5 and @entity5 ( @entity5 ) 2 micrograms/kg/day sc, days 6-14. This was scheduled to be repeated every 3 weeks. Local radiation therapy was added for @entity0 in whom it was indicated. A total of 17 @entity0 (mean age, 66 yr) were enrolled. Ten @entity0 had @entity8 with measurable lesions and 2 @entity0 experienced partial remission lasting 2 and 3 months, respectively. Six of 7 @entity0 were treated with the same modality of treatment as an adjuvant. Three died of progressive disease after 3-7 months and three others have survived for 3-11 months. The @entity1 of the chemotherapy were mainly bone marrow suppression, despite @entity5 support. Transient @entity2 was also noticed. These results indicate that this combined a treatment can be given to @entity0 with acceptable @entity1 . The degree of @entity7 was greater than expected, partly due to the advanced age of the @entity0 and the low dose of @entity5 . In addition, 8 available thyroid specimens were examined for the @entity6 gene and @entity6 , but all were negative. Further study of @entity9 by this cooperative group will be carried out.

title: Intensive chemotherapy for @entity9 : combination of @entity4 , XXXX , etoposide and @entity10 with granulocyte @entity5 support. Chemotherapy Committee, The Japanese Society of Thyroid Surgery.

answer: @entity3


abstract: The Japanese Society of Thyroid Surgery undertook a pilot study of treatment for @entity9 in a cooperative setting. The treatment consisted of @entity4 40 mg/m2 drip intravenous infusion (div), day 1, @entity3 60 mg/m2 iv, day 1, etoposide 100 mg/m2/day div, days 1-3, @entity10 5 mg/body/day sc, days 1-5 and @entity5 ( @entity5 ) 2 micrograms/kg/day sc, days 6-14. This was scheduled to be repeated every 3 weeks. Local radiation therapy was added for @entity0 in whom it was indicated. A total of 17 @entity0 (mean age, 66 yr) were enrolled. Ten @entity0 had @entity8 with measurable lesions and 2 @entity0 experienced partial remission lasting 2 and 3 months, respectively. Six of 7 @entity0 were treated with the same modality of treatment as an adjuvant. Three died of progressive disease after 3-7 months and three others have survived for 3-11 months. The @entity1 of the chemotherapy were mainly bone marrow suppression, despite @entity5 support. Transient @entity2 was also noticed. These results indicate that this combined a treatment can be given to @entity0 with acceptable @entity1 . The degree of @entity7 was greater than expected, partly due to the advanced age of the @entity0 and the low dose of @entity5 . In addition, 8 available thyroid specimens were examined for the @entity6 gene and @entity6 , but all were negative. Further study of @entity9 by this cooperative group will be carried out.

title: Intensive chemotherapy for @entity9 : combination of @entity4 , @entity3 , etoposide and @entity10 with granulocyte XXXX support. Chemotherapy Committee, The Japanese Society of Thyroid Surgery.

answer: @entity5


abstract: The Japanese Society of Thyroid Surgery undertook a pilot study of treatment for @entity9 in a cooperative setting. The treatment consisted of @entity4 40 mg/m2 drip intravenous infusion (div), day 1, @entity3 60 mg/m2 iv, day 1, etoposide 100 mg/m2/day div, days 1-3, @entity10 5 mg/body/day sc, days 1-5 and @entity5 ( @entity5 ) 2 micrograms/kg/day sc, days 6-14. This was scheduled to be repeated every 3 weeks. Local radiation therapy was added for @entity0 in whom it was indicated. A total of 17 @entity0 (mean age, 66 yr) were enrolled. Ten @entity0 had @entity8 with measurable lesions and 2 @entity0 experienced partial remission lasting 2 and 3 months, respectively. Six of 7 @entity0 were treated with the same modality of treatment as an adjuvant. Three died of progressive disease after 3-7 months and three others have survived for 3-11 months. The @entity1 of the chemotherapy were mainly bone marrow suppression, despite @entity5 support. Transient @entity2 was also noticed. These results indicate that this combined a treatment can be given to @entity0 with acceptable @entity1 . The degree of @entity7 was greater than expected, partly due to the advanced age of the @entity0 and the low dose of @entity5 . In addition, 8 available thyroid specimens were examined for the @entity6 gene and @entity6 , but all were negative. Further study of @entity9 by this cooperative group will be carried out.

title: Intensive chemotherapy for @entity9 : combination of @entity4 , @entity3 , etoposide and XXXX with granulocyte @entity5 support. Chemotherapy Committee, The Japanese Society of Thyroid Surgery.

answer: @entity10


abstract: BACKGROUND: This study evaluates the effects on clinical and biochemical parameters of @entity6 -containing probiotic supplementation adjunctive to initial periodontal therapy in @entity0 with @entity7 ( @entity7 ). METHODS: Thirty @entity0 with @entity7 were included and divided into two groups. Every @entity0 had, in each quadrant, >= 2 teeth each with approximal sites with a @entity1 ( @entity1 ) of 5 to 7 mm and gingival index (GI) of >= 2. The test group received scaling and root planing (SRP) and probiotic-containing lozenges. The control group received SRP and placebo lozenges. Plaque index (PI), GI, @entity2 on probing (BOP), @entity1 , and @entity3 were measured. Gingival crevicular fluid (GCF) was sampled for the analysis of @entity5 and @entity4 by enzyme-linked immunosorbent assay. All evaluations were performed at baseline and on days 21, 90, 180, and 360. RESULTS: Differences in intergroup comparisons of PI, GI, BOP, and @entity1 were found to be significant (P <0.05) in favor of the test group at all time points. Decreased GCF @entity5 levels and increased @entity4 levels were found to be significant up to day 180 (P <0.05). Mean values of @entity3 were significantly higher in the test group compared with the control group on days 90, 180, and 360. CONCLUSIONS: Lozenges containing @entity6 may be a useful supplement in moderately deep pockets of @entity0 with @entity7 . Low @entity5 and high @entity4 levels may indicate the role of the lozenges in reduction of inflammation-associated markers up to day 180.

title: Clinical and Biochemical Evaluation of Lozenges Containing XXXX as an Adjunct to Non-Surgical Periodontal Therapy in @entity7 .

answer: @entity6


abstract: BACKGROUND: This study evaluates the effects on clinical and biochemical parameters of @entity6 -containing probiotic supplementation adjunctive to initial periodontal therapy in @entity0 with @entity7 ( @entity7 ). METHODS: Thirty @entity0 with @entity7 were included and divided into two groups. Every @entity0 had, in each quadrant, >= 2 teeth each with approximal sites with a @entity1 ( @entity1 ) of 5 to 7 mm and gingival index (GI) of >= 2. The test group received scaling and root planing (SRP) and probiotic-containing lozenges. The control group received SRP and placebo lozenges. Plaque index (PI), GI, @entity2 on probing (BOP), @entity1 , and @entity3 were measured. Gingival crevicular fluid (GCF) was sampled for the analysis of @entity5 and @entity4 by enzyme-linked immunosorbent assay. All evaluations were performed at baseline and on days 21, 90, 180, and 360. RESULTS: Differences in intergroup comparisons of PI, GI, BOP, and @entity1 were found to be significant (P <0.05) in favor of the test group at all time points. Decreased GCF @entity5 levels and increased @entity4 levels were found to be significant up to day 180 (P <0.05). Mean values of @entity3 were significantly higher in the test group compared with the control group on days 90, 180, and 360. CONCLUSIONS: Lozenges containing @entity6 may be a useful supplement in moderately deep pockets of @entity0 with @entity7 . Low @entity5 and high @entity4 levels may indicate the role of the lozenges in reduction of inflammation-associated markers up to day 180.

title: Clinical and Biochemical Evaluation of Lozenges Containing @entity6 as an Adjunct to Non-Surgical Periodontal Therapy in XXXX .

answer: @entity7


abstract: UNASSIGNED: Purpose: A. fumigatus infections represent a major threat for @entity0 with a suppressed immune system. Early diagnosis is of importance for a favorable outcome but appears to be difficult due to limited diagnostic procedures. Here we investigated the sensitivity of high-resolution ultrasound (HRU) for the detection of A. fumigatus infection in the liver. Materials and Methods: BALB/c @entity1 were intravenously infected with A. fumigatus and monitored by HRU, Doppler sonography (CCDS), contrast-enhanced ultrasound (CEUS), and real-time strain color-coded elastography (CCE) using a multi-frequency probe (6-15MHz). Contrast media bolus injection of @entity4 micro-bubbles was applied and digital cine-loops from the arterial phase, as well as the portal venous phase up to the late phase of the whole liver were analyzed. All data were correlated to the histopathological findings. Results: Using HRU and CEUS, a sonic shadow was detected in all infected animals. All @entity2 -infected nodes from 3-6mm in the liver showed a shadow with rim enhancement and no intranodal enhancement when using CEUS.A. fumigatus infection was confirmed by CFU assessment and histopathological analysis. @entity3 were not associated with shadowing on B-mode. In contrast, @entity3 with a diameter above 5mm and a higher stiffness in CCE generated particularly an arterial rim enhancement and portal venous washout without contrast media uptake in the late phase. In addition, CEUS was able to define dynamic capillary microvascularization of infected liver areas. Conclusion: Liver lesions associated with A. fumigatus infection can be detected in @entity1 when combined with CEUS and CCE in vivo.

title: High-Resolution Ultrasound Including Contrast-Enhanced Ultrasound (CEUS) for the Detection of Gas Formation during XXXX Infection in @entity1 .

answer: @entity2


abstract: UNASSIGNED: Purpose: A. fumigatus infections represent a major threat for @entity0 with a suppressed immune system. Early diagnosis is of importance for a favorable outcome but appears to be difficult due to limited diagnostic procedures. Here we investigated the sensitivity of high-resolution ultrasound (HRU) for the detection of A. fumigatus infection in the liver. Materials and Methods: BALB/c @entity1 were intravenously infected with A. fumigatus and monitored by HRU, Doppler sonography (CCDS), contrast-enhanced ultrasound (CEUS), and real-time strain color-coded elastography (CCE) using a multi-frequency probe (6-15MHz). Contrast media bolus injection of @entity4 micro-bubbles was applied and digital cine-loops from the arterial phase, as well as the portal venous phase up to the late phase of the whole liver were analyzed. All data were correlated to the histopathological findings. Results: Using HRU and CEUS, a sonic shadow was detected in all infected animals. All @entity2 -infected nodes from 3-6mm in the liver showed a shadow with rim enhancement and no intranodal enhancement when using CEUS.A. fumigatus infection was confirmed by CFU assessment and histopathological analysis. @entity3 were not associated with shadowing on B-mode. In contrast, @entity3 with a diameter above 5mm and a higher stiffness in CCE generated particularly an arterial rim enhancement and portal venous washout without contrast media uptake in the late phase. In addition, CEUS was able to define dynamic capillary microvascularization of infected liver areas. Conclusion: Liver lesions associated with A. fumigatus infection can be detected in @entity1 when combined with CEUS and CCE in vivo.

title: High-Resolution Ultrasound Including Contrast-Enhanced Ultrasound (CEUS) for the Detection of Gas Formation during @entity2 Infection in XXXX .

answer: @entity1


abstract: OBJECTIVES: To describe utilization of 3% @entity1 ( @entity1 ) in hospitalized @entity0 and to evaluate the association between @entity1 use and length of stay (LOS) in a real-world setting. STUDY DESIGN: This multicenter retrospective cohort study included @entity0 <=12 months hospitalized with @entity2 between October 2008 and September 2011 using the Pediatric Health Information System. @entity1 use was categorized as trial, rescue, daily, or sporadic. Differences in LOS were compared after matching daily @entity1 recipients and nonrecipients on propensity score. RESULTS: There were 63,337 hospitalizations for @entity2 . @entity1 was used in 24 of 42 hospitals and 2.9% of all hospitalizations. @entity1 use increased from 0.4% of visits in 2008 to 9.2% of visits in 2011. There was substantial variation in @entity1 use across hospitals (range 0.1%-32.6%). When used, @entity1 was given daily during 60.6% of hospitalizations, sporadically in 10.4%, as a trial in 11.3%, and as a rescue in 17.7%. The propensity score-matched analysis of daily @entity1 recipients (n=953) vs nonrecipients (n=953) showed no difference in mean LOS ( @entity1 2.3 days vs nonrecipients 2.5 days; b-coefficient -0.04; 95% CI -0.15, 0.07; P=.5) or odds of staying longer than 1, 2, or 3 days. Daily @entity1 recipients had a 33% decreased odds of staying in the hospital>4 days compared with nonrecipients (OR 0.67; 95% CI 0.47, 0.97; P=.03). CONCLUSIONS: Variation in @entity1 use and the lack of association between @entity1 and mean LOS demonstrates the need for further research to standardize @entity1 use and better define the @entity0 for whom @entity1 will be most beneficial.

title: Utilization of nebulized 3% saline in @entity0 hospitalized with XXXX .

answer: @entity2


abstract: OBJECTIVES: To describe utilization of 3% @entity1 ( @entity1 ) in hospitalized @entity0 and to evaluate the association between @entity1 use and length of stay (LOS) in a real-world setting. STUDY DESIGN: This multicenter retrospective cohort study included @entity0 <=12 months hospitalized with @entity2 between October 2008 and September 2011 using the Pediatric Health Information System. @entity1 use was categorized as trial, rescue, daily, or sporadic. Differences in LOS were compared after matching daily @entity1 recipients and nonrecipients on propensity score. RESULTS: There were 63,337 hospitalizations for @entity2 . @entity1 was used in 24 of 42 hospitals and 2.9% of all hospitalizations. @entity1 use increased from 0.4% of visits in 2008 to 9.2% of visits in 2011. There was substantial variation in @entity1 use across hospitals (range 0.1%-32.6%). When used, @entity1 was given daily during 60.6% of hospitalizations, sporadically in 10.4%, as a trial in 11.3%, and as a rescue in 17.7%. The propensity score-matched analysis of daily @entity1 recipients (n=953) vs nonrecipients (n=953) showed no difference in mean LOS ( @entity1 2.3 days vs nonrecipients 2.5 days; b-coefficient -0.04; 95% CI -0.15, 0.07; P=.5) or odds of staying longer than 1, 2, or 3 days. Daily @entity1 recipients had a 33% decreased odds of staying in the hospital>4 days compared with nonrecipients (OR 0.67; 95% CI 0.47, 0.97; P=.03). CONCLUSIONS: Variation in @entity1 use and the lack of association between @entity1 and mean LOS demonstrates the need for further research to standardize @entity1 use and better define the @entity0 for whom @entity1 will be most beneficial.

title: Utilization of nebulized 3% saline in XXXX hospitalized with @entity2 .

answer: @entity0


abstract: Lens membrane preparations have been shown to have a remarkable @entity4 which increases in the inner nuclear region of the lens and has been correlated with the @entity1 (C)/phospholipid (PL) ratio. However, the distribution of these lipids in single lenses had not been determined. Utilizing a new technique for isolating consecutive layers of a @entity0 lens, lipid composition and contents of seven pairs of normal lenses from subjects ranging from 54 to 77 years old have been analyzed. It was found that the PL content remains relatively constant at 22-24 micrograms/mg through all but the nuclear 10-15% of the lens dry weight where it drops precipitously to about 7 micrograms/mg. The C distribution is more complex; the C content is at a low level of 14 micrograms/mg in the outer cortical 15-20%, rises to 25 micrograms/mg in the inner cortical 40-60% of the total lens weight, and drops to 12 micrograms/mg upon reaching the nucleus. Thus, the continuous increase in the lens C/PL ratio is due to the increase in C in the cortex and the large decrease in PL in the nucleus. Analyses of phospholipid and @entity3 composition in the different regions of the lens indicate significant differences. However, the abundance of @entity6 contributing to the @entity4 of the membrane has only minor variation. The lens has a remarkably low overall lipid content of 4% and only 2% in the nuclear region. Calculation of the surface area of the nuclear fiber cell suggests that less than one-third of the membrane is made of PL bilayer. Thus, a mosaic of PL and C patches or some other type of structure involving membrane fusion must be present. Conversion of the % dry weight occupied by the concentric fiber fractions to their location on the lens axis in mm indicates that the nuclear 15% dry weight of the tissue occupies more than 50% of the axial length. This region contains the @entity5 and the primary lens fibers. Similarly, the metabolically active outer 20% of the dry weight accounts for less than 10% of the visual axial length and contains cells undergoing terminal differentiation. Cataractous lenses have lipid distributions similar to those of the normal lenses suggesting that membrane lipid is either not involved in @entity2 formation or that the primary insult is localized in an undetectable small number of fiber cells.

title: Membrane XXXX and phospholipid in consecutive concentric sections of @entity0 lenses.

answer: @entity1


abstract: Lens membrane preparations have been shown to have a remarkable @entity4 which increases in the inner nuclear region of the lens and has been correlated with the @entity1 (C)/phospholipid (PL) ratio. However, the distribution of these lipids in single lenses had not been determined. Utilizing a new technique for isolating consecutive layers of a @entity0 lens, lipid composition and contents of seven pairs of normal lenses from subjects ranging from 54 to 77 years old have been analyzed. It was found that the PL content remains relatively constant at 22-24 micrograms/mg through all but the nuclear 10-15% of the lens dry weight where it drops precipitously to about 7 micrograms/mg. The C distribution is more complex; the C content is at a low level of 14 micrograms/mg in the outer cortical 15-20%, rises to 25 micrograms/mg in the inner cortical 40-60% of the total lens weight, and drops to 12 micrograms/mg upon reaching the nucleus. Thus, the continuous increase in the lens C/PL ratio is due to the increase in C in the cortex and the large decrease in PL in the nucleus. Analyses of phospholipid and @entity3 composition in the different regions of the lens indicate significant differences. However, the abundance of @entity6 contributing to the @entity4 of the membrane has only minor variation. The lens has a remarkably low overall lipid content of 4% and only 2% in the nuclear region. Calculation of the surface area of the nuclear fiber cell suggests that less than one-third of the membrane is made of PL bilayer. Thus, a mosaic of PL and C patches or some other type of structure involving membrane fusion must be present. Conversion of the % dry weight occupied by the concentric fiber fractions to their location on the lens axis in mm indicates that the nuclear 15% dry weight of the tissue occupies more than 50% of the axial length. This region contains the @entity5 and the primary lens fibers. Similarly, the metabolically active outer 20% of the dry weight accounts for less than 10% of the visual axial length and contains cells undergoing terminal differentiation. Cataractous lenses have lipid distributions similar to those of the normal lenses suggesting that membrane lipid is either not involved in @entity2 formation or that the primary insult is localized in an undetectable small number of fiber cells.

title: Membrane @entity1 and phospholipid in consecutive concentric sections of XXXX lenses.

answer: @entity0


abstract: Thirty-five eligible @entity0 with disseminated @entity4 received intramuscular recombinant leukocyte interferon (IFN-rA), 50 X 10(6) U/m2 three times weekly (TIW) for an intended duration of 12 weeks concomitant with daily oral @entity10 , 1,200 mg/d in four divided doses. For all study @entity0 , the median survival time was six months. Among 21 "good risk" @entity0 (performance score [PS] 0, 1 and no prior chemotherapy), we observed seven partial regressions (33%). Six @entity0 had stability of disease (29%), seven had immediate disease progression, and one discontinued treatment after two doses without @entity1 evaluation due to side effects. Times to disease progression of five @entity0 with regressions of soft-tissue disease were 2.1, 3.3, 3.5, 3.7, and 4.3 months. Two @entity0 had partial regressions of lung nodules for 2.0 and 3.8 months. We observed one regression among 14 "poor risk" @entity0 (PS 2, 3, or prior chemotherapy). A 46-year-old @entity0 with prior treatment had a partial regression of soft-tissue disease for 4.1 months. Four "poor risk" @entity0 @entity2 stability, and nine progressed immediately. @entity9 (WBC count less than 4,100/microL) affected 21 (66%) of 32 @entity0 with WBC count data. The median count was 3,100/microL; range, 1,300 to 8,400/microL. We detected two cases of mild @entity7 (100,000 and 120,000/microL). Other noteworthy @entity3 included moderate-to-severe @entity5 (34%), @entity6 (63%), and fatigue (80%). All @entity0 experienced @entity8 . Twenty @entity0 had dosage decreases during the first cycle, and 14 of the 16 @entity0 remaining on study after the first cycle required dosage reductions. The overall response rate is similar to our prior studies with IFN-rA as a single agent using TIW doses of 50 X 10(6) U/m2 and 12 X 10(6) U/m2 among 31 and 30 @entity0 , respectively.

title: Phase II study of recombinant leukocyte A interferon (IFN-rA) plus XXXX in disseminated @entity4 .

answer: @entity10


abstract: Thirty-five eligible @entity0 with disseminated @entity4 received intramuscular recombinant leukocyte interferon (IFN-rA), 50 X 10(6) U/m2 three times weekly (TIW) for an intended duration of 12 weeks concomitant with daily oral @entity10 , 1,200 mg/d in four divided doses. For all study @entity0 , the median survival time was six months. Among 21 "good risk" @entity0 (performance score [PS] 0, 1 and no prior chemotherapy), we observed seven partial regressions (33%). Six @entity0 had stability of disease (29%), seven had immediate disease progression, and one discontinued treatment after two doses without @entity1 evaluation due to side effects. Times to disease progression of five @entity0 with regressions of soft-tissue disease were 2.1, 3.3, 3.5, 3.7, and 4.3 months. Two @entity0 had partial regressions of lung nodules for 2.0 and 3.8 months. We observed one regression among 14 "poor risk" @entity0 (PS 2, 3, or prior chemotherapy). A 46-year-old @entity0 with prior treatment had a partial regression of soft-tissue disease for 4.1 months. Four "poor risk" @entity0 @entity2 stability, and nine progressed immediately. @entity9 (WBC count less than 4,100/microL) affected 21 (66%) of 32 @entity0 with WBC count data. The median count was 3,100/microL; range, 1,300 to 8,400/microL. We detected two cases of mild @entity7 (100,000 and 120,000/microL). Other noteworthy @entity3 included moderate-to-severe @entity5 (34%), @entity6 (63%), and fatigue (80%). All @entity0 experienced @entity8 . Twenty @entity0 had dosage decreases during the first cycle, and 14 of the 16 @entity0 remaining on study after the first cycle required dosage reductions. The overall response rate is similar to our prior studies with IFN-rA as a single agent using TIW doses of 50 X 10(6) U/m2 and 12 X 10(6) U/m2 among 31 and 30 @entity0 , respectively.

title: Phase II study of recombinant leukocyte A interferon (IFN-rA) plus @entity10 in disseminated XXXX .

answer: @entity4


abstract: Utilization and requirement of egg protein in Japanese @entity0 with two levels of energy intake were estimated. In experiment 1, fifteen female students were given semi-purified diet containing whole egg as the sole @entity1 source for 12 days. @entity1 intakes were 50 for five, 75 for two and 100 mg N/kg for eight subjects. Habitual energy intake was determined individually by detailed inquiry about the foods consumed before the experiment was started. Mean energy intake was 33 kcal/kg. In experiment 2, eighteen other subjects were given the same diet containing four intake levels of egg protein (30, 50, 75, 100 mg N/kg) with an energy intake of about 100 kcal/day added to that calculated by the food intake inquiry. The mean energy intake was 37 kcal/kg. The total @entity1 contents of the experimental diet, urine and feces were analyzed and the @entity1 balance was estimated from these figures. Significant rectilinear relations were found between @entity1 intake (X, mg N/kg) and balance (Y, mg N/kg). The regression equations were: Experiment 1: Y = 0.256X - 34.4 (n = 15, r = 0.742) Experiment 2: Y = 0.326X - 29.7 (n = 18, r = 0.645) The maintenance intakes of whole egg protein for apparent @entity1 equilibrium were calculated to be 134 and 91 mg N/kg with energy intakes of 33 and 37 kcal/kg, respectively. Net protein utilization (NPU) and digestibility of egg protein were calculated using the obligatory N losses previously determined in Japanese @entity0 . The NPUs at the maintenance level of egg protein with energy intakes of 33 and 37 kcal/kg were estimated as 31 and 47, respectively. The mean digestibility of egg protein was 96%.

title: Utilization and requirement of egg protein in Japanese XXXX .

answer: @entity0


abstract: BACKGROUND: Vascular invasion (VI) is an important predictor of distant @entity1 and possible radioactive iodine (RAI) benefit in follicular, H  rthle cell, and poorly differentiated @entity3 , but its role in well-differentiated @entity5 (WDTC) remains unclear. METHODS: Archived pathological material of all differentiated @entity3 @entity0 undergoing primary surgical treatment at Memorial Sloan-Kettering Cancer Center between 1986 and 2003 was reviewed by two dedicated thyroid pathologists. Only WDTCs were included in the present study. Standard statistical methods were used to assess the relationship between VI and outcomes of interest, including 10-year disease-specific survival (DSS), @entity4 ( @entity4 ), and distant recurrence-free survival (DRFS). RESULTS: VI was present in 47 of 698 WDTC (6.7%). VI was significantly associated with @entity2 size >4.0   cm, extrathyroidal extension, distant @entity1 , and RAI treatment. On univariate analysis, VI was predictive of decreased 10-year DRFS, but not DSS or @entity4 . On multivariate analysis, VI was not an independent predictor of DRFS. Univariate survival analysis of 422 RAI-na  ve WDTC showed that both size >4   cm and VI were predictors of outcome, but only size remained independently predictive on multivariate analysis. CONCLUSION: The presence of VI is not an independent predictor of outcome in WDTC.

title: Prognostic Value of Vascular Invasion in Well-Differentiated XXXX .

answer: @entity5


abstract: The origin of fibroblasts, their proliferative activity and roles in the early stages of periodontal repair were investigated in order to better understand the periodontal healing process in @entity3 of the @entity0 after guided tissue regenerative therapy. Newly divided cells were identified by immunolocalization of @entity1 ( @entity1 ) injected 1 hour prior to sacrificing the animals. At 1 and 2 weeks after creation of the defects, the lesions were occupied primarily by granulation tissue. Under this condition, periodontal ligaments (PDL) fibroblasts in a coronal portion of the remaining PDL close to wounds proliferated actively, migrated along the root surface and formed fibrous connective tissue on the surface. Similarly, the fibroblasts adjacent to the bone surface also showed proliferative activity and engaged in active formation of fibrous connective tissue on the bone surface. The majority of labeled cells in both areas were located in the extravascular area. At 3 and 4 weeks, the defects were filled with an increased amount of new connective tissue and bone. The labeled fibroblasts were preferentially found in the most coronal portion of connective tissue formed on the root surface that was in direct contact with inflamed tissue, and the collagen fibers projected into granulation tissue. In areas of active bone formation, numerous labeled fibroblasts were located in connective tissue adjacent to the newly-formed bone. However, fibroblasts in the endosteum of new bone were rarely labeled These results indicate that fibroblasts involved in periodontal repair originate primarily from both the remaining PDL and alveolar bone, and actively engage in fibrous connective tissue formation in the early stages of periodontal repair The ability of PDL fibroblasts to proliferate, migrate, and form connective tissue on the root surfaces in the early repair stages appears to play a crucial role in the formation of the PDL and cementum, and consequently, in periodontal regeneration in the absence of root resorption and @entity2 . As the formation of new connective tissue and bone continues, the precursor cells for fibroblasts and osteoblasts are supplied locally through the continued divisions of the fibroblastic cells in association with the newly-formed connective tissue. Paravascular and endosteal cells appear to be minor contributors to new cell population during @entity3 repair in the @entity0 .

title: The origin of fibroblasts and their role in the early stages of horizontal XXXX healing in the @entity0 .

answer: @entity3


abstract: The origin of fibroblasts, their proliferative activity and roles in the early stages of periodontal repair were investigated in order to better understand the periodontal healing process in @entity3 of the @entity0 after guided tissue regenerative therapy. Newly divided cells were identified by immunolocalization of @entity1 ( @entity1 ) injected 1 hour prior to sacrificing the animals. At 1 and 2 weeks after creation of the defects, the lesions were occupied primarily by granulation tissue. Under this condition, periodontal ligaments (PDL) fibroblasts in a coronal portion of the remaining PDL close to wounds proliferated actively, migrated along the root surface and formed fibrous connective tissue on the surface. Similarly, the fibroblasts adjacent to the bone surface also showed proliferative activity and engaged in active formation of fibrous connective tissue on the bone surface. The majority of labeled cells in both areas were located in the extravascular area. At 3 and 4 weeks, the defects were filled with an increased amount of new connective tissue and bone. The labeled fibroblasts were preferentially found in the most coronal portion of connective tissue formed on the root surface that was in direct contact with inflamed tissue, and the collagen fibers projected into granulation tissue. In areas of active bone formation, numerous labeled fibroblasts were located in connective tissue adjacent to the newly-formed bone. However, fibroblasts in the endosteum of new bone were rarely labeled These results indicate that fibroblasts involved in periodontal repair originate primarily from both the remaining PDL and alveolar bone, and actively engage in fibrous connective tissue formation in the early stages of periodontal repair The ability of PDL fibroblasts to proliferate, migrate, and form connective tissue on the root surfaces in the early repair stages appears to play a crucial role in the formation of the PDL and cementum, and consequently, in periodontal regeneration in the absence of root resorption and @entity2 . As the formation of new connective tissue and bone continues, the precursor cells for fibroblasts and osteoblasts are supplied locally through the continued divisions of the fibroblastic cells in association with the newly-formed connective tissue. Paravascular and endosteal cells appear to be minor contributors to new cell population during @entity3 repair in the @entity0 .

title: The origin of fibroblasts and their role in the early stages of horizontal @entity3 healing in the XXXX .

answer: @entity0


abstract: UNASSIGNED: Early detection of long term conditions is predicated on assumptions that lifestyle changes and medications can be used to reduce or manage the risk of condition progression. However, ambiguity remains about the nature and place of diagnostic disclosure to @entity0 in newly recognised or asymptomatic 'pre' conditions such as early stage @entity1 ( @entity1 ). The disclosure of a diagnosis is relevant to instigating strategies which rely on actively engaging @entity0 as self-managers of their own care. Whilst primary care routinely records a diagnosis of early stage @entity1 , little is known about how @entity0 learn about the fact that they have @entity1 or how they respond to this. This study aimed to explore @entity0 ' experiences of disclosure of @entity1 in primary care settings. A nested qualitative study of @entity0 recruited to a trial of an intervention for @entity1 @entity0 in Greater Manchester, UK was undertaken. A purposive sample of 26 @entity0 , with a mean age of 72 years (range 59-89, median 71), were interviewed during 2012. Interview transcripts were analysed using constant comparative techniques. Narrative accounts reflected limited or partial disclosure of @entity1 ; often cast in vague terms as "nothing to worry about". How @entity0 described themselves in terms of participation and their tendencies towards 'active' or 'passive' involvement in consultations emerged as important components of narratives around disclosure. The findings illuminate the ways in which diagnosis is oriented in a context where it is possible to meet the requirements for remuneration under a pay for performance system of primary care, whilst apparently not disclosing a label or a diagnosis to @entity0 . This challenges the presumptions inherent in wider health policy objectives that are increasingly built on the notion of responsible @entity0 and the ethos of the active support of self-management for pre-conditions.

title: XXXX in primary care and the limits of instrumental rationality in chronic illness self-management.

answer: @entity1


abstract: Earlier studies showed that @entity4 produced both increases and decreases in short-circuit current across the @entity1 proximal colon. @entity4 metabolites had opposing effects: @entity7 elicited only increases in Isc, and @entity6 elicited only decreases. The stimulant effects involved FP receptors, but the receptors involved in mediating the inhibitory effects remained undefined. Here we show that the tissue, although it is capable of producing both @entity4 and @entity3 , did not produce @entity7 in measurable amounts. The selective DP receptor agonist BW 245C did not mimic the inhibitory effects of @entity4 , producing only dose-dependent increases in short-circuit current. Further, these responses were not significantly inhibited by BW @entity8 . Cross-desensitization experiments suggested that the stimulant effects of BW 245C involved the EP receptor. However, on a standard preparation ( @entity0 platelets), both @entity4 and BW 245C inhibited @entity2 -induced aggregation and were antagonized by BW @entity8 . @entity7 had no effects. The decreases in short-circuit current across the @entity1 colonic epithelium elicited by @entity4 and @entity6 are not mimicked by other @entity5 , nor by the selective agonist BW 245C, and thus appear to involve receptors other than the classical DP receptor.

title: Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW XXXX ) on the @entity1 colonic epithelium: an argument for a different DP receptor?

answer: @entity8


abstract: Earlier studies showed that @entity4 produced both increases and decreases in short-circuit current across the @entity1 proximal colon. @entity4 metabolites had opposing effects: @entity7 elicited only increases in Isc, and @entity6 elicited only decreases. The stimulant effects involved FP receptors, but the receptors involved in mediating the inhibitory effects remained undefined. Here we show that the tissue, although it is capable of producing both @entity4 and @entity3 , did not produce @entity7 in measurable amounts. The selective DP receptor agonist BW 245C did not mimic the inhibitory effects of @entity4 , producing only dose-dependent increases in short-circuit current. Further, these responses were not significantly inhibited by BW @entity8 . Cross-desensitization experiments suggested that the stimulant effects of BW 245C involved the EP receptor. However, on a standard preparation ( @entity0 platelets), both @entity4 and BW 245C inhibited @entity2 -induced aggregation and were antagonized by BW @entity8 . @entity7 had no effects. The decreases in short-circuit current across the @entity1 colonic epithelium elicited by @entity4 and @entity6 are not mimicked by other @entity5 , nor by the selective agonist BW 245C, and thus appear to involve receptors other than the classical DP receptor.

title: Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW @entity8 ) on the XXXX colonic epithelium: an argument for a different DP receptor?

answer: @entity1


abstract: 1. Outer segment patches excised in the light were used to investigate the effects of exogenous calmodulin and an endogenous inhibitory factor on the @entity2 -gated channel of frog rods. 2. Calmodulin shifted to the right the dose-response relation for activation of the channels by @entity3 , but did not change the maximum current or the form of the relation. Reversal of this effect by removal of calmodulin was accelerated by brief exposure to saturating [ @entity3 ]. Inhibition by calmodulin required @entity1 and gave as much as a 5-fold decrease in current for an [ @entity3 ] functionally comparable to the presumed physiological [ @entity2 ]. 3. Exposure to low [ @entity0 ]i (tens of nanomolar) appeared to irreversibly remove or inactivate an endogenous channel inhibitory factor from the patches, increasing the current at low [ @entity3 ]. Like calmodulin, this factor slowed the voltage-dependent channel-gating kinetics and did not change the maximum current. However, unlike calmodulin, the endogenous factor remained stably associated with the patches at high [ @entity0 ]i (1 microM), even with exposure to saturating [ @entity3 ]. 4. After the low- @entity0 treatment increased the current, calmodulin reduced the current to about the same level as it had before the low- @entity0 treatment, giving a larger fractional suppression. Furthermore, patches with high initial sensitivity to @entity3 had small low- @entity0 effects and large calmodulin effects, while the reverse was true for patches with low initial agonist sensitivity. 5. Application of trypsin to the intracellular surface of the patch prevented the responses to calmodulin and to low [ @entity0 ]i, suggesting involvement of a cytoplasmic portion of the channel. However, trypsin also reduced the total agonist-induced patch current. 6. Our results are consistent with a model in which calmodulin and an endogenous @entity1 -binding protein compete for the same site, inhibiting channel opening or @entity2 binding. The tight association of the endogenous factor with the channel even at relatively low [ @entity0 ]i suggests that in the transducing rod it may inhibit the channels most of the time in darkness and in dim light, preventing any potential inhibitory effects of calmodulin. The endogenous factor would be expected to leave the channel only in bright or prolonged light, when the [ @entity0 ]i is thought to be very low.

title: Modulation of the XXXX -gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor.

answer: @entity2


abstract: 1. The molecular mechanisms underlying pH regulation of skeletal muscle @entity1 -sensitive K+ (KATP) channels were studied using the patch clamp technique in the inside-out configuration. Two effects of intracellular protons were studied in detail: the decrease in magnitude of single-channel currents and the increase in open probability (Po) of @entity0 -inhibited channels. 2. The pH dependence of inward unit currents under different ionic conditions was in poor agreement with either a direct block of the pore by protons or an indirect proton-induced conformational change, but was compatible with the protonation of surface charges located near the cytoplasmic entrance of the pore. This latter electrostatic mechanism was modelled using Gouy-Chapman-Stern theory, which predicted the data accurately with a surface charge density of about 0.1 negative elementary charges per square nanometre and a pK (pH value for 50% effect) value for protonation of these charges of 6.25. The same mechanism, i.e. neutralization of negative surface charges by cation binding, could also account for the previously reported reduction of inward unit currents by @entity3 . 3. Intracellular alkalization did not affect Po of the KATP channels. Acidification increased Po. In the presence of 0.1 mM @entity1 (no @entity3 ), the channel activation vs. pH relationship could be fitted with a sigmoid curve with a Hill coefficient slightly above 2 and a pK value of 6. This latter value was dependent on the @entity1 concentration, decreasing from 6.3 in 30 microM @entity1 to 5.3 in 1 microM @entity1 . 4. Conversely, the channel inhibition vs. @entity1 concentration curve was shifted to the right when the pH was lowered. At pH 7.1, the @entity1 concentration causing half-maximal inhibition was about 10 microM. At pH 5.4, it was about 400 microM. The Hill coefficient values remained slightly below 2. Similar effects were observed when @entity2 was used as the inhibitory @entity0 . 5. These results confirm that a reciprocal competitive link exists between proton and @entity0 binding sites. Quantitatively, they are in full agreement with a steady-state model of a KATP channel possessing four identical protonation sites (microscopic pK, 6) allosterically connected to the channel open state and two identical @entity0 sites (microscopic @entity1 dissociation constant, approximately 30 microM) connected to the closed state.

title: Modification by protons of frog skeletal muscle KATP channels: effects on ion conduction and XXXX inhibition.

answer: @entity0


abstract: 1. The repetitive firing properties of neonatal and adult @entity0 hypoglossal motoneurones (HMs) were investigated in a brainstem slice preparation. Neonatal HMs could be classified into two main groups: (1) neurones with a decrementing or adapting firing pattern (type D); exhibiting an early and a late phase; and (2) neurones with an incrementing or accelerating firing pattern (type I). 2. The pattern of repetitive firing changed markedly during development. While most HMs recorded from young @entity0 (< postnatal day (P) 4) were type D, the majority of HMs recorded during the second postnatal week were type I. In adults (> @entity4 ), nearly all HMs had a decrementing firing pattern, characterized by a brief period of adaptation and high steady-state firing rates. 3. The @entity1 -dependent after-hyperpolarization (AHP) was shortest in type I neonatal HMs, and decreased in amplitude during trains of @entity2 ( @entity2 ). In type D neurones, these same trains caused a slight enhancement of AHP amplitude. In adult HMs, with a decrementing firing pattern, trains of @entity2 also caused summation of the AHP. 4. Type D neonatal HMs showed a progressive prolongation of the AP during repetitive firing. In contrast, type I neonatal HMs had almost no change in AP duration. In adult HMs the AP was short and experienced only a modest increase in duration during fast repetitive firing. 5. The function relating steady-state firing frequency to injected current (f-I curve) was linear. The mean steady-state f-I slope was significantly higher in neonates than in adults (approximately 30 vs. approximately 20 Hz nA-1), and was weakly correlated with input resistance. The f-I slope was negatively correlated with AHP duration in neonatal HMs only. In addition, for a given AHP duration the slope was higher in neonatal HMs. 6. Two threshold behaviours were observed among neonatal HMs: (a) a progressive rhythmic firing threshold, and (b) a sudden transition from subthreshold to regular repetitive firing. Current threshold for repetitive firing was strongly correlated with cell input conductance. @entity3 had higher minimal steady firing rates (fmin) than type D HMs. In neonates, fmin was strongly correlated with AHP duration. Adult HMs showed a weaker correlation between these two parameters, and fmin was higher than predicted by AHP duration. 7. In summary, HMs responded to depolarizing current pulses with different firing patterns during postnatal development.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Repetitive firing properties of developing XXXX brainstem motoneurones.

answer: @entity0


abstract: Importance: Important differences exist in the pattern and timing of distant @entity1 between @entity6 -initiated (HPV+) and HPV- @entity5 ( @entity5 ). However, our understanding of the natural history of distant @entity1 in HPV+ @entity5 and its implications for surveillance is limited. Objective: To investigate the rate, pattern, and timing of distant @entity1 in advanced-stage @entity5 treated definitively with concomitant chemoradiotherapy. Design, Setting, and @entity0 : In a retrospective review, we identified 291 @entity0 with pathologically diagnosed stages III to IVB @entity5 and known HPV status from a @entity2 registry at the Cleveland Clinic. @entity0 were treated from January 1, 1996, through December 31, 2013. Details of treatment failure and the natural history of the disease were retrieved from the electronic medical records. Interventions: All @entity0 were treated with definitive concomitant chemoradiotherapy. Main Outcomes and Measures: The primary outcome was the rate and timing of distant @entity1 . Secondary outcomes included the pattern of distant failure and survival after distant @entity1 . Results: Thirty-seven @entity0 developed distant @entity1 after definitive treatment, including 28 of 252 @entity0 with HPV+ disease and 9 of 39 @entity0 with @entity3 . The 3-year projected distant control rate was higher in the HPV+ group (88% vs 74%; P   =   .01). The median time to develop distant @entity1 was also longer after the completion of treatment for HPV+ disease compared with @entity3 (16.4 vs 7.2 months; P   =   .008). We detected a trend in @entity0 with HPV+ disease for more distant metastatic sites involved than in those with @entity3 (2.04 vs 1.33 sites; P   =   .09). Although the lung was the most common distant site involved in HPV+ and @entity3 (HPV+ group, 23 of 28 @entity0 [82%]; HPV- group, 7 of 9 @entity0 [78%]), the HPV+ group had @entity1 to several subsets atypical for @entity4 , including the brain, kidney, skin, skeletal muscle, and axillary lymph nodes in 2 @entity0 each and in the intra-abdominal lymph nodes in 3 @entity0 . The rate of 3-year overall survival was higher in the HPV+ group (89.9% vs 62.0%; P   <   .001), as was the median survival after the occurrence of distant @entity1 regardless of additional treatment (25.6 vs 11.1 months; P   <   .001). Conclusions and Relevance: This retrospective review suggests that distant @entity1 in @entity0 with HPV+ @entity5 occurs significantly later after completion of chemoradiotherapy than in @entity0 with @entity3 . @entity6 -initiated @entity5 also appears to involve a greater number of subsites and metastatic sites infrequently seen in @entity4 . Distant @entity1 in HPV+ @entity5 has unique characteristics and a natural history that may require alternative surveillance strategies.

title: Effect of @entity6 on Patterns of Distant Metastatic Failure in XXXX Treated With Chemoradiotherapy.

answer: @entity5


abstract: Importance: Important differences exist in the pattern and timing of distant @entity1 between @entity6 -initiated (HPV+) and HPV- @entity5 ( @entity5 ). However, our understanding of the natural history of distant @entity1 in HPV+ @entity5 and its implications for surveillance is limited. Objective: To investigate the rate, pattern, and timing of distant @entity1 in advanced-stage @entity5 treated definitively with concomitant chemoradiotherapy. Design, Setting, and @entity0 : In a retrospective review, we identified 291 @entity0 with pathologically diagnosed stages III to IVB @entity5 and known HPV status from a @entity2 registry at the Cleveland Clinic. @entity0 were treated from January 1, 1996, through December 31, 2013. Details of treatment failure and the natural history of the disease were retrieved from the electronic medical records. Interventions: All @entity0 were treated with definitive concomitant chemoradiotherapy. Main Outcomes and Measures: The primary outcome was the rate and timing of distant @entity1 . Secondary outcomes included the pattern of distant failure and survival after distant @entity1 . Results: Thirty-seven @entity0 developed distant @entity1 after definitive treatment, including 28 of 252 @entity0 with HPV+ disease and 9 of 39 @entity0 with @entity3 . The 3-year projected distant control rate was higher in the HPV+ group (88% vs 74%; P   =   .01). The median time to develop distant @entity1 was also longer after the completion of treatment for HPV+ disease compared with @entity3 (16.4 vs 7.2 months; P   =   .008). We detected a trend in @entity0 with HPV+ disease for more distant metastatic sites involved than in those with @entity3 (2.04 vs 1.33 sites; P   =   .09). Although the lung was the most common distant site involved in HPV+ and @entity3 (HPV+ group, 23 of 28 @entity0 [82%]; HPV- group, 7 of 9 @entity0 [78%]), the HPV+ group had @entity1 to several subsets atypical for @entity4 , including the brain, kidney, skin, skeletal muscle, and axillary lymph nodes in 2 @entity0 each and in the intra-abdominal lymph nodes in 3 @entity0 . The rate of 3-year overall survival was higher in the HPV+ group (89.9% vs 62.0%; P   <   .001), as was the median survival after the occurrence of distant @entity1 regardless of additional treatment (25.6 vs 11.1 months; P   <   .001). Conclusions and Relevance: This retrospective review suggests that distant @entity1 in @entity0 with HPV+ @entity5 occurs significantly later after completion of chemoradiotherapy than in @entity0 with @entity3 . @entity6 -initiated @entity5 also appears to involve a greater number of subsites and metastatic sites infrequently seen in @entity4 . Distant @entity1 in HPV+ @entity5 has unique characteristics and a natural history that may require alternative surveillance strategies.

title: Effect of XXXX on Patterns of Distant Metastatic Failure in @entity5 Treated With Chemoradiotherapy.

answer: @entity6


abstract: BACKGROUND: This study tested the hypothesis that right atrial (RA) mechanics are altered in @entity0 after repair of @entity3 with @entity4 (PAIVS) and @entity2 ( @entity2 ) and to explore their relationships with right ventricular (RV) diastolic function and P-wave indices. METHODS: Thirty-six adult @entity0 , 16 with PAIVS and 20 with @entity2 @entity0 , and 20 age-matched healthy subjects were studied. Right atrial mechanics were assessed using speckle tracking echocardiography (STE) with quantification of positive, negative, and total strain, and strain rates at ventricular systole (aSRs ), early diastole (aSRed ), and atrial contraction (aSRac ). Right ventricular diastolic function was assessed by Doppler interrogation and STE. Maximum P-wave duration and P-wave dispersion were measured. RESULTS: Compared with controls, PAIVS and @entity2 @entity0 had significantly lower RA positive and total strain, aSRs and aSRed (all P < 0.05). Parameters of RV diastolic function including transtricuspid early (E) and late (A) diastolic inflow velocities, E/A ratio, early diastolic tricuspid annular velocity (e), early to late diastolic annular velocity ratio, E/e ratio, and RV early diastolic strain rate were found to correlate significantly with RA positive and total strain and aSRed (all P < 0.05). Maximum P-wave duration and P-wave dispersion increased progressively across control, @entity2 , and PAIVS groups (P for trend <0.001). Both P-wave indices correlated negatively with RA positive strain, total strain, and aSRed (all P < 0.05). CONCLUSION: Impairment of RA mechanics occurs in @entity0 long term after repair of PAIVS and @entity2 and is associated with RV @entity1 , longer P-wave duration, and greater P-wave dispersion.

title: Right Atrial Mechanics Long-Term after Biventricular Repair of XXXX or Stenosis with Intact Ventricular Septum.

answer: @entity3


abstract: UNASSIGNED: A thermostable oxidant- and @entity1 -stable @entity13 was produced from a newly isolated B. firmus DWD-33. Maximum enzyme productivity was obtained in medium containing 0.8% @entity11 and 1.2% @entity8 powder as @entity4 and @entity9 sources, respectively. Enzyme purification increased the specific activity to 24-fold with 27% recovery and molecular weight of 33.5 kDa. As compared with other microbial uricases, the pure enzyme showed high thermostability and other unique characters. The Vmax was 387   M/min, the turnover number (Kcat) was 21.8*103 s-1 and the catalytic efficiency (Kcat /Km) was 2.76*108 s-1M-1. The enzyme was stable at pH 7.0-10.0 and up to 70   C. The optimal reaction temperature and pH of enzyme were 50   C and pH 8.0, respectively. @entity6 significantly enhanced the enzymatic activity, while @entity12 , @entity7 and @entity10 greatly suppressed the activity. @entity6 might be the @entity13 cofactor as the enzyme activity was restored after its addition to @entity7 -chelated enzyme. The enzyme inhibition by the @entity5 -chelating agent @entity14 suggests that this enzyme is a cuprouricase-type. The purified @entity13 retained 72 and 82% of its original activity even after incubation with 0.5% @entity2 and 0.5% @entity1 for 6 h, respectively. The application of enzyme in the in vitro measurement of @entity3 in @entity0 sera was promising and none of @entity3 analogs was a competitive substrate for enzyme, indicative of the high specificity of @entity13 with respect to @entity3 measurement in vitro. The reaction can be applied in clinical laboratory for 10 min only due to the absorbances are lineary related to @entity3 concentration up to 500   M.

title: Purification, characterization and in vitro application of a thermostable oxidant- and XXXX -stable @entity13 from a newly isolated Bacillus firmus DWD-33.

answer: @entity1


abstract: UNASSIGNED: A thermostable oxidant- and @entity1 -stable @entity13 was produced from a newly isolated B. firmus DWD-33. Maximum enzyme productivity was obtained in medium containing 0.8% @entity11 and 1.2% @entity8 powder as @entity4 and @entity9 sources, respectively. Enzyme purification increased the specific activity to 24-fold with 27% recovery and molecular weight of 33.5 kDa. As compared with other microbial uricases, the pure enzyme showed high thermostability and other unique characters. The Vmax was 387   M/min, the turnover number (Kcat) was 21.8*103 s-1 and the catalytic efficiency (Kcat /Km) was 2.76*108 s-1M-1. The enzyme was stable at pH 7.0-10.0 and up to 70   C. The optimal reaction temperature and pH of enzyme were 50   C and pH 8.0, respectively. @entity6 significantly enhanced the enzymatic activity, while @entity12 , @entity7 and @entity10 greatly suppressed the activity. @entity6 might be the @entity13 cofactor as the enzyme activity was restored after its addition to @entity7 -chelated enzyme. The enzyme inhibition by the @entity5 -chelating agent @entity14 suggests that this enzyme is a cuprouricase-type. The purified @entity13 retained 72 and 82% of its original activity even after incubation with 0.5% @entity2 and 0.5% @entity1 for 6 h, respectively. The application of enzyme in the in vitro measurement of @entity3 in @entity0 sera was promising and none of @entity3 analogs was a competitive substrate for enzyme, indicative of the high specificity of @entity13 with respect to @entity3 measurement in vitro. The reaction can be applied in clinical laboratory for 10 min only due to the absorbances are lineary related to @entity3 concentration up to 500   M.

title: Purification, characterization and in vitro application of a thermostable oxidant- and @entity1 -stable XXXX from a newly isolated Bacillus firmus DWD-33.

answer: @entity13


abstract: To overcome shortcomings in the delivery of care for @entity1 various approaches have been developed including a system whereby care of @entity1 is shared in a formal manner between general practitioners and hospital specialists. The feasibility, acceptability and cost-effectiveness of a computerised model of shared care were investigated in three matched groups of @entity0 attending @entity1 clinics in Glasgow. Glasgow Blood Pressure Clinic attenders considered suitable for shared care by their consultants were randomised to shared care (n = 277) or continued clinic follow-up; a further control group (n = 277) was identified from an independent nurse-practitioner clinic. After 2 years of follow-up, feasibility was estimated by the proportion of @entity0 who had undergone an adequate review (blood pressure, serum @entity2 and electrocardiograph); acceptability to general practitioners and @entity0 was assessed by questionnaires; cost-effectiveness was calculated as the cost (to National Health Service and @entity0 ) per adequate review. The drop-out rate for shared care over 2 years was 3% compared with 14% for the outpatient clinic and 9% for the nurse-practitioner clinic. In year 2, rates of adequate reviews were 82%, 52% and 75%, respectively. Blood pressure control was similar in the groups. Of 297 general practitioners invited to participate, 85% agreed and 68% wished to continue participation after 2 years. About 50% of shared care @entity0 preferred this method of follow-up compared with their earlier experience of clinic attendance. Shared care was more cost-effective than either conventional or nurse-practitioner clinic follow-up, especially with respect to cost to the @entity0 ; costs per adequate review (pound sterling) were 28.96, 50.55 and 30.95, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Delivery of care for XXXX .

answer: @entity1


abstract: AIM: Defining a set of research priorities for @entity1 nursing care in the Italian context. DESIGN: A two-step study design based on a modified Delphi technique was undertaken in 2013. METHODS: In the first stage of research, five systematic reviews of literature were performed. Among them 865 recommendations in @entity1 nursing care emerged, and 217 (25.1%) were categorized at level IV or lower, thus based on a lack of knowledge and therefore a potential research area. Homogeneous recommendations among the 217 emerged and were categorized by two researchers independently: 96 final recommendations were identified and transformed into items embodied into a questionnaire. A Likert scale ranging from 1 (very low) to 5 (very high) was used to collect the consensus regarding priority. For that purpose a sample of 200 nurses was randomly considered. Potential @entity0 were invited to cooperate via email through a letter reporting aims and methods. In the first round 85 nurses participated; in the third and final round, only 13 nurses took part. RESULTS: @entity0 have identified 14 research priorities categorized into three main areas: 1) education strategies' effectiveness (n=7); 2) models of care delivery and advanced nursing education effectiveness (n=4); and 3) in specific clinical issues (n=3). CONCLUSIONS: More research on @entity0 education and on models of care delivery and advanced nursing education should be included in any future Italian agenda.

title: Research priorities in Italian XXXX nursing care: findings from a Delphi study.

answer: @entity1


abstract: OBJECTIVE: Cases of @entity1 after a transforaminal lumbar interbody fusion with a single cage (unilateral TLIF) had been reported, but the phenomenon has not been explained satisfactorily. The purpose of this study was to determine its incidence, causes, and risk factors. METHODS: We did retrospective study with 546 @entity0 who underwent a unilateral TLIF, and used CT and MRI to study the causes of @entity4 that appeared within a week postoperatively. Clinical and radiological results were compared by dividing the @entity0 into the symptomatic group and asymptomatic group. RESULTS: Contralateral symptoms occurred in 32 (5.9%) of the @entity0 underwent unilateral TLIF. The most common cause of contralateral symptoms was a @entity3 in 22 (68.8%), screw malposition in 4 (12.5%), newly developed @entity7 in 3 (9.3%), @entity5 in 1 (3.1%), and unknown origin in 2 @entity0 (6.3%). 16 (50.0%) of the 32 @entity0 received revision surgery. There was no difference in visual analogue scale and @entity2 index between the two groups at discharge. Both preoperative and postoperative contralateral foraminal areas were significantly smaller, and postoperative segmental angle was significantly greater in the symptomatic group comparing to those of the asymptomatic group (p<0.05). CONCLUSION: The incidence rate is not likely to be small (5.9%). If unilateral TLIF is performed for cases when preoperative @entity3 already exists or when a large restoration of segmental @entity6 is required, the probability of developing @entity1 is increased and caution from the surgeon is needed.

title: Acute XXXX after Unilateral Transforaminal Lumbar Interbody Fusion.

answer: @entity1


abstract: INTRODUCTION: Preventive care is often not performed during the ambulatory office visit due to the acute nature of the visit. One possible strategy is the use of a lay @entity1 screening navigator using the lay health worker model. METHODS: A training program for the lay @entity1 screening navigator and a @entity0 registry for @entity2 screening was developed. The RE-AIM framework was used to evaluate the intervention. Descriptive statistics were generated for @entity0 demographics. RESULTS: Reach: The lay @entity1 screening navigator contacted 91.9% of eligible @entity0 . Effectiveness: At baseline, 28.6% of @entity0 were current on their @entity2 screening, 40.5% at 6 months, and 42.2% at 12 months. Adoption: @entity0 contacted all reported being receptive to the intervention. IMPLEMENTATION: Of the 368 fecal immunochemical test kits mailed, 151 were returned (41.0%), and 26 (17.2%) were positive. Maintenance: The percentage of @entity0 who were current between 6 months and at 12 months were not significantly different. DISCUSSION: This study demonstrates that the use of a lay @entity1 screening navigator to increase the rate of @entity2 screening is a viable strategy.

title: Using a lay @entity1 screening navigator to increase XXXX screening rates.

answer: @entity2


abstract: INTRODUCTION: Preventive care is often not performed during the ambulatory office visit due to the acute nature of the visit. One possible strategy is the use of a lay @entity1 screening navigator using the lay health worker model. METHODS: A training program for the lay @entity1 screening navigator and a @entity0 registry for @entity2 screening was developed. The RE-AIM framework was used to evaluate the intervention. Descriptive statistics were generated for @entity0 demographics. RESULTS: Reach: The lay @entity1 screening navigator contacted 91.9% of eligible @entity0 . Effectiveness: At baseline, 28.6% of @entity0 were current on their @entity2 screening, 40.5% at 6 months, and 42.2% at 12 months. Adoption: @entity0 contacted all reported being receptive to the intervention. IMPLEMENTATION: Of the 368 fecal immunochemical test kits mailed, 151 were returned (41.0%), and 26 (17.2%) were positive. Maintenance: The percentage of @entity0 who were current between 6 months and at 12 months were not significantly different. DISCUSSION: This study demonstrates that the use of a lay @entity1 screening navigator to increase the rate of @entity2 screening is a viable strategy.

title: Using a lay XXXX screening navigator to increase @entity2 screening rates.

answer: @entity1


abstract: OBJECTIVE: To establish 18  @entity2 -positron emission tomography/computed tomography (F-PET/CT) performances for the detection of local recurrence in a population of @entity0 with biochemical failure after primary curative treatment for @entity1 . MATERIAL AND METHOD: From February 2011  to February 2014, 55  @entity0 underwent a F-PET/CT for biochemical relapse after primary radical therapy for @entity1 localized or locally advanced. Primary therapies for @entity1 were 19  radical prostatectomy, 18  radiotherapy, 13  radiotherapy with hormonal treatment, 3  brachytherapy. The median age was 65  years (50-79). The initial staging was 17  T1, 23  T2  and 15  T3, 52  were N0  and N1 3. The median PSA was 12 (3-127). The Gleason score was less than 7, equal to 7  and greater than 7  at 21, 25  and 9  @entity0 respectively. The average time to recurrence was 69.5  months (8-147) with a median PSA of 2.9ng/mL (0.48-41). RESULTS: In 42  cases, F-PET/CT showed uptake, suggesting a recurrence, metastatic (6), nodal (26) or local isolated (10). The focal uptake in PET commissioned in 5  cases prostate biopsy, confirming the histological recurrence of @entity1 in 4  cases. Among the 10  @entity0 with isolated local recurrence, 8  underwent salvage radiotherapy. Of the 13  cases where the (F-PET/CT) showed no recurrence, 7  multiparametric MRI were performed. The MRI showed a local recurrence in 3  @entity0 , the diagnoses were confirmed with prostate biopsy for two of them. CONCLUSION: In our study, for the @entity0 with biochemical relapse of @entity1 localized or locally advanced, (F-PET/CT) was able to detect local recurrence isolated in nearly half the cases but did not show sufficient sensitivity to exclude recurrence local if negative. It does not replace MRI or additional prostate biopsy. LEVEL OF EVIDENCE: 5.

title: [Biochemical recurrence after curative treatment for XXXX : Performance of choline PET/CT in the assessment of local recurrence].

answer: @entity1


abstract: BACKGROUND: It is unclear how the extent of surgical lymph node clearance influences prognosis after surgery for @entity2 . METHODS: This nationwide, population-based cohort study included 1044 @entity2 @entity0 who had undergone esophagectomy between 1987 and 2010 in Sweden, with follow-up until 2012. The independent role of lymph node removal in relation to survival was analyzed using Cox proportional hazards regression, providing hazard ratios (HRs) with 95% confidence intervals (CIs), adjusted for age, sex, comorbidity, @entity1 ( @entity1 ) stage, neo-adjuvant treatment, surgeon volume, and calendar period. Statistical tests were two-sided, except tests for trend. RESULTS: Analyzed as a linear variable, a higher number of lymph nodes removed did not influence the overall five-year mortality (adjusted HR = 1.00, 95% CI = 0.99 to 1.01). @entity0 in the third (7-15 nodes) and fourth (16-114 nodes) quartiles of removed nodes did not demonstrate any decreased overall five-year mortality compared with those in the lowest two quartiles (<7 nodes) (HR = 1.13, 95% CI = 0.95 to 1.35 and HR = 1.17, 95% CI = 0.94 to 1.46, respectively). In early @entity1 stages (Tis-T1) the hazard ratios indicated a worse survival with more lymphadenectomy using the median as cutoff (HR = 1.53, 95% CI = 1.13 to 2.06). Increased lymph node removal did not decrease mortality in any specific @entity1 stage. A greater number of metastatic nodes and a higher positive-to-negative node ratio were associated with strongly increased mortality. All results were similar when disease-specific mortality was analyzed. CONCLUSION: This population-based study indicates that more extensive lymph node clearance during surgery for @entity2 may not improve survival. These results challenge current clinical guidelines, and further research is needed to change clinical practice.

title: Extent of lymph node removal during XXXX surgery and survival.

answer: @entity2


abstract: UNASSIGNED: The aims of this study are to investigate the occurrence characteristics of Acanthopanax ( c   w   ji  ) @entity3 and to provide objective evidence for the rational use of the medicine. Fifty-seven cases of Acanthopanax @entity3 were collected from several professional databases in China. The statistical data of the @entity0 were analyzed with Visual FoxPro 6.0 and Office Excel 2003 by Microsoft (Redmond, WA, USA). The male:female incidence ratio was 0.5:1. Fifty-six (98.25%) @entity0 were older than 30 years. Thirty-nine (68.42%) @entity0 had an unknown @entity2 history. Nine (15.79%) @entity0 used Acanthopanax for unlabeled indications. In most (98.25 %) @entity0 , Acanthopanax was used in the form of dosage injection. @entity3 occurred within 30 minutes after treatment in 52 (94.54%) @entity0 , and all episodes occurred during the infusion process. In two (3.51%) @entity0 , the episode occurred when they used Acanthopanax for the second time. In one (1.75%) @entity0 , the episode occurred during the third time of use. The clinical symptoms of @entity3 are diversified, but all @entity0 presented with @entity1 . Acanthopanax injections that led to @entity3 were produced exclusively by four manufacturers. Four (7.02%) @entity0 died and 49 (85.96%) @entity0 were cured, but the status of four @entity0 is unknown. Because an Acanthopanax injection may cause @entity3 and can be fatal in severe cases, physicians and @entity0 must pay close attention to using it rationally. Clinicians should carefully consult the allergic constitution of their @entity0 , strictly follow the guidelines of the drug, use Acanthopanax in the oral dosage form as much as possible, and strengthen therapeutic monitoring.

title: Literature analysis of Acanthopanax XXXX in China.

answer: @entity3


abstract: Typically, intrathecal @entity8 therapy(ITB)for @entity2 is continuously required because the @entity2 can recur if the ITB is stopped. Thus, an infusion pump for the ITB is permanently implanted. Some sporadic cases exhibiting remarkable improvements in their @entity2 and @entity7 have been reported after implanting the ITB pump. We experienced a rare case involving removal of the ITB pump after the @entity2 resolved and the @entity7 markedly improved. A 15-year-old @entity0 developed a @entity3 due to rupture of an @entity1 in the right anterior cerebral artery. Her initial Glasgow Coma Scale score was 4(E1V1M2). Trapping of the @entity1 and decompression craniotomy were performed. Subsequently, she underwent a tracheotomy, and a percutaneous gastrostomy( @entity5 )tube was implanted because of persistent @entity7 . Cranioplasty and lumbar-peritoneal shunt for normal pressure @entity6 were performed after 1 month. An ITB pump was implanted to improve the @entity2 observed mainly in the lower extremities 61 days after @entity4 onset. Right hemiparesis remained due to Kernohan's notch. After transfer to the rehabilitation hospital, her @entity7 and @entity2 remarkably improved(1.9 to 1.0 and 3.5 to 1.0 on the Ashworth scale for the upper and lower extremities, respectively). The tracheostomy and @entity5 tubes were removed, and the @entity8 dose was gradually reduced. She was completely off @entity8 after 7 months, and she was discharged with a short leg brace and a cane for walking. The @entity8 pump was then removed. In this case, temporary ITB improved the @entity2 and @entity7 .

title: [Complete Remission of Consciousness Disturbances and Spasticity due to a Severe @entity3 after Intrathecal XXXX Therapy:A Case Report].

answer: @entity8


abstract: Typically, intrathecal @entity8 therapy(ITB)for @entity2 is continuously required because the @entity2 can recur if the ITB is stopped. Thus, an infusion pump for the ITB is permanently implanted. Some sporadic cases exhibiting remarkable improvements in their @entity2 and @entity7 have been reported after implanting the ITB pump. We experienced a rare case involving removal of the ITB pump after the @entity2 resolved and the @entity7 markedly improved. A 15-year-old @entity0 developed a @entity3 due to rupture of an @entity1 in the right anterior cerebral artery. Her initial Glasgow Coma Scale score was 4(E1V1M2). Trapping of the @entity1 and decompression craniotomy were performed. Subsequently, she underwent a tracheotomy, and a percutaneous gastrostomy( @entity5 )tube was implanted because of persistent @entity7 . Cranioplasty and lumbar-peritoneal shunt for normal pressure @entity6 were performed after 1 month. An ITB pump was implanted to improve the @entity2 observed mainly in the lower extremities 61 days after @entity4 onset. Right hemiparesis remained due to Kernohan's notch. After transfer to the rehabilitation hospital, her @entity7 and @entity2 remarkably improved(1.9 to 1.0 and 3.5 to 1.0 on the Ashworth scale for the upper and lower extremities, respectively). The tracheostomy and @entity5 tubes were removed, and the @entity8 dose was gradually reduced. She was completely off @entity8 after 7 months, and she was discharged with a short leg brace and a cane for walking. The @entity8 pump was then removed. In this case, temporary ITB improved the @entity2 and @entity7 .

title: [Complete Remission of Consciousness Disturbances and Spasticity due to a Severe XXXX after Intrathecal @entity8 Therapy:A Case Report].

answer: @entity3


abstract: BACKGROUND: This study aimed to investigate the association of seven common @entity2 with @entity9 ( @entity9 ) in the Chinese Mainland population. METHODS: @entity0 were recruited from a great swathe of mainland from 2009 to 2013 for the cohort study. The demographic characteristics between @entity0 with @entity9 or with @entity2 , including age, sex, smoking status, @entity4 etc. were analyzed using the   (2) test. Cox proportional hazard regression models were used to determine the independent effects of @entity1 on the risks of any types of @entity2 in the model and age, sex, @entity4 and @entity6 adjusted were used after that. RESULTS: A total of 39367 @entity0 were enrolled in the study and 1634 (4.2%) subjects with missing information on @entity9 and the @entity2 were excluded. Compared to those without @entity1 , after adjusting for age, sex, @entity4 and @entity6 , the incidences of @entity7 , chronic @entity3 , chronic @entity10 , @entity5 , @entity5 or @entity8 in @entity1 @entity0 were independently higher, with odd ratios of 0.235 (95% Confidence Interval [CI], 0.117-0.473), 0.845 (95% CI, 0.731-0.976), 0.585 (95% CI, 0.540-0.634), 0.875 (95% CI, 0.806-0.951), 0.843 (95% CI, 0.787-0.903) respectively. Only inflammatory @entity11 did not show any clinical significance. CONCLUSION: There was a decreased incidence of @entity2 in the @entity1 @entity0 compared with non- @entity1 subjects. Except for inflammatory @entity11 , @entity7 , chronic @entity3 , chronic @entity10 , @entity5 , @entity5 and @entity8 were associated with @entity9 of Chinese individuals, independently of @entity4 and @entity6 , and @entity9 might reduce the risk of these diseases.

title: Relationship between Type 2 XXXX and @entity2 : Cohort Study in Chinese Adults.

answer: @entity1


abstract: BACKGROUND: This study aimed to investigate the association of seven common @entity2 with @entity9 ( @entity9 ) in the Chinese Mainland population. METHODS: @entity0 were recruited from a great swathe of mainland from 2009 to 2013 for the cohort study. The demographic characteristics between @entity0 with @entity9 or with @entity2 , including age, sex, smoking status, @entity4 etc. were analyzed using the   (2) test. Cox proportional hazard regression models were used to determine the independent effects of @entity1 on the risks of any types of @entity2 in the model and age, sex, @entity4 and @entity6 adjusted were used after that. RESULTS: A total of 39367 @entity0 were enrolled in the study and 1634 (4.2%) subjects with missing information on @entity9 and the @entity2 were excluded. Compared to those without @entity1 , after adjusting for age, sex, @entity4 and @entity6 , the incidences of @entity7 , chronic @entity3 , chronic @entity10 , @entity5 , @entity5 or @entity8 in @entity1 @entity0 were independently higher, with odd ratios of 0.235 (95% Confidence Interval [CI], 0.117-0.473), 0.845 (95% CI, 0.731-0.976), 0.585 (95% CI, 0.540-0.634), 0.875 (95% CI, 0.806-0.951), 0.843 (95% CI, 0.787-0.903) respectively. Only inflammatory @entity11 did not show any clinical significance. CONCLUSION: There was a decreased incidence of @entity2 in the @entity1 @entity0 compared with non- @entity1 subjects. Except for inflammatory @entity11 , @entity7 , chronic @entity3 , chronic @entity10 , @entity5 , @entity5 and @entity8 were associated with @entity9 of Chinese individuals, independently of @entity4 and @entity6 , and @entity9 might reduce the risk of these diseases.

title: Relationship between Type 2 @entity1 and XXXX : Cohort Study in Chinese Adults.

answer: @entity2


abstract: BACKGROUND: The present study aimed to identify the spatial distribution of @entity2 and determine the @entity3 control program parameters in the regions supervised by Shiraz University of Medical Sciences in 2006-2012. METHODS: The present ecological study was performed on 1797 @entity3 @entity0 in Shiraz University in 2006-2012 which were recorded by health centers using @entity3 Register software. The study data were collected through over-counting and analyzed using the SPSS statistical software (ver. 19). Besides, the maps were drawn by ArcGIS, version 10. RESULTS: The incidence rate of @entity3 was 4.8 in 100,000 at the end of 2012. Success in treatment was adequate only in 2012 (89.7%). However, recovery of @entity1 was not adequate in any of the study years. In our study, the majority of the @entity0 belonged to the 25-34 years age group that constitutes the active faction of the society. Moreover, the maps provided by GIS showed a high incidence rate of extra @entity1 in Firozabad Township during 7 years (2.7 in 100000 populations). CONCLUSION: Incidence of @entity3 in the regions supervised by Shiraz University of Medical Sciences follows a specific pattern, which requires exclusive studies for further evaluation of the incidence determinatives in various environmental and social conditions.

title: Spatio-Temporal Pattern of XXXX in the Regions Supervised by Shiraz University of Medical Sciences 2006-2012.

answer: @entity2


abstract: UNASSIGNED: Background: Knowledge regarding the @entity2 ) and HPV vaccine uptake among ethnic minorities is poorly explored in Denmark. The objective of this study was to explore attitudes and knowledge towards HPV vaccination among Arab mothers and their daughters. Methods: Five Arabic-speaking focus groups with mothers of vaccine-eligible @entity0 and three focus groups with daughters were conducted. The @entity0 were recruited through different social clubs. A phenomenological approach was used to investigate attitudes and knowledge of HPV vaccination. Meaning condensation inspired by Amedeo Giorgi was used to analyse the transcribed material. Results: A total of 23 @entity0 and 13 daughters were included in this study. The mothers' knowledge regarding HPV was limited to the fact that HPV can cause @entity1 . Two focus groups mentioned that HPV is a @entity3 and none of the mothers knew that HPV also causes genital warts. Both mothers and daughters acknowledged that the daughters have deeper insight into health-related issues. A gap of knowledge between generations was identified, as mothers and daughters obtained health information from different sources: mothers used the Arabic TV channels as a source of knowledge and daughters had a range of sources, e.g. school, internet, and Western TV channels. The consequence of these differences in obtaining knowledge is that mothers and daughters lack a common language to discuss health issues. Mothers were influenced by Arabic society, while daughters had created a hybrid of Arabic and Danish. Each generation had its own reasons for accepting the vaccine. The level of HPV knowledge and awareness did not affect their uptake decision in that all the participating mothers had accepted the vaccine for their daughters. Conclusions: Educational programs should target both mothers and daughters because mothers have an inadequate knowledge about HPV. This is likely to bridge the gap of knowledge between mothers and daughters, which constitutes a barrier between the generations.

title: Attitudes towards XXXX vaccination among Arab ethnic minority in Denmark: A qualitative study.

answer: @entity2


abstract: One of the key requirements for the accurate calculation of free energy differences is proper sampling of conformational space. Especially in biological applications, molecular dynamics simulations are often confronted with rugged energy surfaces and high energy barriers, leading to insufficient sampling and, in turn, poor convergence of the free energy results. In this work, we address this problem by employing enhanced sampling methods. We explore the possibility of using @entity3 ( @entity3 ) to speed up the exploration process in free energy simulations. To obtain improved free energy differences from such simulations, it is necessary to account for the effects of the bias due to the guiding forces. We demonstrate how this can be accomplished for the Bennett's acceptance ratio (BAR) and the @entity2 ( @entity2 ) methods. While BAR is considered among the most efficient methods available for free energy calculations, the @entity2 method developed by Christ and van Gunsteren is a promising development that reduces the computational costs of free energy calculations by simulating a single reference state. To evaluate the accuracy of both approaches in connection with enhanced sampling, @entity2 was implemented in CHARMM. For testing, we employ benchmark systems with analytical reference results and the mutation of @entity1 to @entity0 . We find that @entity3 with reweighting can provide accurate results for BAR and @entity2 where conventional molecular dynamics simulations fail. In addition, we compare the performance of @entity2 with other free energy methods. We briefly discuss the implications of our results and provide practical guidelines for conducting free energy simulations with @entity3 .

title: Enhanced Sampling in Free Energy Calculations: Combining XXXX with the Bennett's Acceptance Ratio and Enveloping Distribution Sampling Methods.

answer: @entity3


abstract: 1. A pharmacological investigation of the distribution of non-cholinergic excitatory nerve cell bodies was performed on the @entity1 's isolated perfused rectum with attached Remak's nerve supply. 2. Electrical stimulation of Remak's nerve trunk produced a contraction and a discharge of action potentials in the nerve branches which supply the smooth muscle of the rectum. Both responses were virtually blocked by @entity2 when applied via the caudal mesenteric artery. 3. The contractile effect following stimulation of the nerve trunk was inhibited more effectively by @entity2 when application was restricted to the trunk rather than to the intestine. 4. The contractile effect of stimulating the nerve branches was unaffected by @entity2 . 5. It is concluded that ganglionic transmission, which is mediated by nicotinic receptors, occurs in the @entity0 of Remak's nerve but not in @entity0 of the enteric plexuses. Therefore, cell bodies of the postganglionic neurones which are considered to be non-cholinergic are located in Remak's nerve @entity0 .

title: Evidence that cell bodies of non-cholinergic, excitatory neurones which supply the smooth muscle of the XXXX rectum are located in the @entity0 of Remak's nerve.

answer: @entity1


abstract: 1. A pharmacological investigation of the distribution of non-cholinergic excitatory nerve cell bodies was performed on the @entity1 's isolated perfused rectum with attached Remak's nerve supply. 2. Electrical stimulation of Remak's nerve trunk produced a contraction and a discharge of action potentials in the nerve branches which supply the smooth muscle of the rectum. Both responses were virtually blocked by @entity2 when applied via the caudal mesenteric artery. 3. The contractile effect following stimulation of the nerve trunk was inhibited more effectively by @entity2 when application was restricted to the trunk rather than to the intestine. 4. The contractile effect of stimulating the nerve branches was unaffected by @entity2 . 5. It is concluded that ganglionic transmission, which is mediated by nicotinic receptors, occurs in the @entity0 of Remak's nerve but not in @entity0 of the enteric plexuses. Therefore, cell bodies of the postganglionic neurones which are considered to be non-cholinergic are located in Remak's nerve @entity0 .

title: Evidence that cell bodies of non-cholinergic, excitatory neurones which supply the smooth muscle of the @entity1 rectum are located in the XXXX of Remak's nerve.

answer: @entity0


abstract: We studied @entity4 in five @entity0 with @entity3 before and after suboccipital decompression. Before operation all @entity0 complained of oscillopsia at rest and visual blurring of fixated targets during and immediately after their heads were in motion. Three @entity0 had @entity2 , one @entity0 had @entity2 in the primary position and on eccentric gaze and one @entity0 had @entity2 on lateral gaze only. Smooth pursuit, @entity2 were markedly impaired. Within two months after operation nystagmus in the primary position had resolved in three @entity0 , and four had complete to near-complete resolution of nystagmus in all gaze positions over subsequent months. Oscillopsia decreased concurrently. affording significant functional visual improvement. One @entity0 had only slight functional improvement and continued to have prominent nystagmus seven years after operation. Smooth pursuit, @entity2 improved in all @entity0 , but none had complete recovery at the higher velocities of stimulation. They still complained of visual blurring associated with head motion, probably due to the poor fixation suppression of @entity2 . Our findings suggest that @entity4 in @entity3 are due to compression of the herniating cerebellum against the caudal brain-stem and not a congenital aberrancy of oculomotor pathways. @entity2 resolved more readily than pursuit or fixation @entity1 , but most @entity0 showed gradual improvement in all abnormalities four months after operation.

title: XXXX : improvement in eye movements after surgical treatment.

answer: @entity3


abstract: UNASSIGNED: The aims of this study were to determine if the protein source of the medium influences @entity2 embryo development and if developmental kinetics, @entity1 and programmed cell death are related. The culture medium was supplemented with either fetal calf serum or bovine serum albumin. The embryos were classified as Fast (n = 1,235) or Slow (n = 485) based on the time required to reach the fourth cell cycle (48 h and 90 h post insemination - hpi -, respectively). The Slow group was further separated into two groups: those presenting exactly 4 cells at 48 hpi (Slow/4 cells) and those that reached the fourth cell cycle at 90 hpi (Slow). Blastocyst quality, DNA fragmentation, mitochondrial membrane potential and signs of apoptosis or @entity0 were evaluated. The Slow group had higher incidence of @entity1 than the Fast group. The embryos supplemented with fetal calf serum had lower quality. DNA fragmentation and mitochondrial membrane potential were absent in embryos at 48 hpi but present at 90 hpi. Early signs of apoptosis were more frequent in the Slow and Slow/4 cell groups than in the Fast group. We concluded that fetal calf serum reduces blastocyst development and quality, but the mechanism appears to be independent of DNA fragmentation. The apoptotic cells detected at 48 hpi reveal a possible mechanism of programmed cell death activation prior to genome activation. The apoptotic cells observed in the slow-developing embryos suggested a relationship between programmed cell death and embryonic developmental kinetics in @entity2 in vitro-produced embryos.

title: Developmental Block and Programmed Cell Death in XXXX Embryos: Effects of Protein Supplementation Source and Developmental Kinetics.

answer: @entity2


abstract: BACKGROUND: The etiology of @entity3 is broad. The peritoneal cavity displays compartmentalization with respect to inflammatory responses, so peripheral blood responses to @entity3 of abdominal vs. non-abdominal origin are expected to be divergent. Lymphocytes and invariant natural killer T (iNKT) cells play important roles in survival from @entity3 , as they dampen the neutrophil and macrophage responses. We assessed whether circulating iNKT cells display distinct phenotypic profiles depending on the presence of abdominal vs. @entity5 with @entity3 . METHODS: @entity0 with @entity3 , defined as infection confirmed microbiologically with a @entity6 ( @entity6 ), were enrolled prospectively. They were categorized as having either exclusively @entity3 of abdominal or exclusively non-abdominal origin. The white blood cell (WBC) count was recorded. Whole-blood staining with monoclonal antibodies to CD3, V-alpha-24 (to identify iNKT cells), and @entity7 (marker of early activation) was applied. RESULTS: Of the 53 enrolled @entity0 , 18 had @entity5 . @entity1 was the most common non-abdominal type. There was no difference in gender, age, Acute Physiology and Chronic Health Evaluation (APACHE) II score, WBC count, or CD3(+) T cells (7.1%  1.6% vs. 6.5%  0.9%; p=0.75) in the two groups. @entity0 with @entity5 had a higher proportion of iNKT cells (2.7%  1.1% vs. 0.89%  0.14%; p=0.032). Correcting for WBC count, this translated into a higher absolute number of iNKT cells (3.4  1.8*10(7)/L vs. 0.74  0.15*10(7)/L; p=0.03). @entity0 with @entity3 of abdominal origin had a lower percentage of @entity7 (+) iNKT cells (9.1%  3.1% vs. 27.2%  5.8%; p=0.028). In @entity0 in shock vs. those who were not, @entity0 with @entity5 exhibited a greater number of iNKT cells (1.47  0.3   v. 0.62  0.1*10(7)/L; p=0.022) and percentage of activated iNKT cells (53  14.5% vs. 17.9  4.8%; p=0.04). @entity0 with @entity5 who died had a lower absolute number of activated iNKT cells (0.8  1.2*10(7)/L vs. 0.34  0.1*10(7)/L; p=0.023); however, no such shock or @entity2 correlation was noted in @entity0 with @entity3 of abdominal origin. CONCLUSIONS: Divergent @entity3 etiologies display distinct blood iNKT cell population changes. In @entity5 , this difference was associated with @entity4 and @entity2 . Elucidating the importance and basis for these changes relative to the response to sources of infection will help clarify appropriate diagnosis and management of the @entity0 with @entity3 .

title: Divergent Invariant Natural Killer T-Cell Response to Sepsis of Abdominal vs. Non-Abdominal Origin in XXXX Beings.

answer: @entity0


abstract: UNASSIGNED: This report describes a case of a 72-year-old Caucasian @entity0 presenting with a large @entity2 with a large persistent epithelial defect, with a longest linear diameter of 7 mm and greatest perpendicular width of 5 mm, affecting epithelium, Bowman membrane, and anterior stroma. @entity3 was resistant to conventional treatment and classified as stage 2 according to Mackie classification. @entity0 was instructed to instill regenerating agent (RGTA) eye drops in the morning, as the first eye drop, once every 5 days in combination with daily cord blood serum (CBS) eye drops 6 times/day. The @entity0 was asked to visit after 1 week (V1), 2 weeks (V2), 3 weeks (V3), and 4 weeks (V4) of study treatment. In V4 treatment, corneal sensitivity improved, and @entity2 healed with resolution of stromal @entity1 . Global treatment tolerance was very satisfactory. @entity0 continued the therapy for a further month after complete healing. Currently, the @entity0 has been followed up for 3 months without any sign of @entity2 recurrence. To the best of our knowledge, this case report describes for the first time the successful combined use of RGTA and CBS eye drops for the treatment of @entity2 resistant to conventional treatment. We hypothesize that RGTA eye drops could provide an optimal migration substrate and that growth factors supplied by CBS eye drops could strengthen the repair process by promoting cell growth over the matrix. Combined RGTA and CBS eye drop therapy could be a new potential option for the successful treatment of resistant @entity2 , particularly when each drug alone is not effective.

title: Synergistic effect of regenerating agent plus cord blood serum eye drops for the treatment of resistant XXXX : a case report and a hypothesis for pathophysiologic mechanism.

answer: @entity2