abstract: BACKGROUND: @entity4 associated with humeral shaft @entity3 is the most @entity1 complicating @entity3 of long bones. The purpose of the study was to review the outcome of surgical management in @entity0 with low energy and high energy @entity4 after humeral shaft @entity3 . METHODS: Eighteen @entity0 were treated operatively for a humeral shaft @entity3 with @entity4 . The mean age was 32.2 years and the mean follow up time was 66.1 months (range: 30-104). The surgical management included @entity3 fixation with early nerve exploration and repair if needed. The @entity0 were divided in two groups based on the energy of @entity2 (low vs. high @entity2 energy). The prevalence of injured and unrecovered nerves and time to nerve recovery were analysed. RESULTS: Five @entity0 sustained low and 13 high energy @entity2 . All @entity0 with low energy @entity2 had an intact (4) or entrapped (1) radial nerve and recovered completely. Full nerve recovery was also achieved in five of 13 @entity0 with high energy @entity2 where the nerve was found intact or entrapped. Signs of initial recovery were present in a mean of 3.2 weeks (range: 1-8) for the low energy group and 12 weeks (range: 3-23) for the high energy group (p=0.036). In these @entity0 , the average time to full recovery was 14 and 26 weeks for the low and high energy @entity2 group respectively. Eight @entity0 with high energy @entity2 had severely damaged nerves and failed to recover, although microsurgical nerve reconstruction was performed in 4 cases. @entity0 with high energy @entity2 had a prolonged @entity3 healing time (18.7 weeks on average) compared to those with low energy @entity3 (10.4 weeks), (p=0.003). CONCLUSIONS: The outcome of the @entity4 following humeral @entity3 is associated to the initial @entity2 . Palsies that are part of a low energy @entity3 uniformly recover and therefore primary surgical exploration seems unnecessary. In high energy @entity3 , neurotmesis or severe contusion must be expected. In this case nerve recovery is unfavourable and the @entity0 should be informed of the poor prognosis and the need of tendon transfers.

title: @entity4 associated with humeral shaft XXXX . Is the energy of @entity2 a prognostic factor?

answer: @entity3


abstract: BACKGROUND: @entity4 associated with humeral shaft @entity3 is the most @entity1 complicating @entity3 of long bones. The purpose of the study was to review the outcome of surgical management in @entity0 with low energy and high energy @entity4 after humeral shaft @entity3 . METHODS: Eighteen @entity0 were treated operatively for a humeral shaft @entity3 with @entity4 . The mean age was 32.2 years and the mean follow up time was 66.1 months (range: 30-104). The surgical management included @entity3 fixation with early nerve exploration and repair if needed. The @entity0 were divided in two groups based on the energy of @entity2 (low vs. high @entity2 energy). The prevalence of injured and unrecovered nerves and time to nerve recovery were analysed. RESULTS: Five @entity0 sustained low and 13 high energy @entity2 . All @entity0 with low energy @entity2 had an intact (4) or entrapped (1) radial nerve and recovered completely. Full nerve recovery was also achieved in five of 13 @entity0 with high energy @entity2 where the nerve was found intact or entrapped. Signs of initial recovery were present in a mean of 3.2 weeks (range: 1-8) for the low energy group and 12 weeks (range: 3-23) for the high energy group (p=0.036). In these @entity0 , the average time to full recovery was 14 and 26 weeks for the low and high energy @entity2 group respectively. Eight @entity0 with high energy @entity2 had severely damaged nerves and failed to recover, although microsurgical nerve reconstruction was performed in 4 cases. @entity0 with high energy @entity2 had a prolonged @entity3 healing time (18.7 weeks on average) compared to those with low energy @entity3 (10.4 weeks), (p=0.003). CONCLUSIONS: The outcome of the @entity4 following humeral @entity3 is associated to the initial @entity2 . Palsies that are part of a low energy @entity3 uniformly recover and therefore primary surgical exploration seems unnecessary. In high energy @entity3 , neurotmesis or severe contusion must be expected. In this case nerve recovery is unfavourable and the @entity0 should be informed of the poor prognosis and the need of tendon transfers.

title: XXXX associated with humeral shaft @entity3 . Is the energy of @entity2 a prognostic factor?

answer: @entity4


abstract: BACKGROUND: @entity4 associated with humeral shaft @entity3 is the most @entity1 complicating @entity3 of long bones. The purpose of the study was to review the outcome of surgical management in @entity0 with low energy and high energy @entity4 after humeral shaft @entity3 . METHODS: Eighteen @entity0 were treated operatively for a humeral shaft @entity3 with @entity4 . The mean age was 32.2 years and the mean follow up time was 66.1 months (range: 30-104). The surgical management included @entity3 fixation with early nerve exploration and repair if needed. The @entity0 were divided in two groups based on the energy of @entity2 (low vs. high @entity2 energy). The prevalence of injured and unrecovered nerves and time to nerve recovery were analysed. RESULTS: Five @entity0 sustained low and 13 high energy @entity2 . All @entity0 with low energy @entity2 had an intact (4) or entrapped (1) radial nerve and recovered completely. Full nerve recovery was also achieved in five of 13 @entity0 with high energy @entity2 where the nerve was found intact or entrapped. Signs of initial recovery were present in a mean of 3.2 weeks (range: 1-8) for the low energy group and 12 weeks (range: 3-23) for the high energy group (p=0.036). In these @entity0 , the average time to full recovery was 14 and 26 weeks for the low and high energy @entity2 group respectively. Eight @entity0 with high energy @entity2 had severely damaged nerves and failed to recover, although microsurgical nerve reconstruction was performed in 4 cases. @entity0 with high energy @entity2 had a prolonged @entity3 healing time (18.7 weeks on average) compared to those with low energy @entity3 (10.4 weeks), (p=0.003). CONCLUSIONS: The outcome of the @entity4 following humeral @entity3 is associated to the initial @entity2 . Palsies that are part of a low energy @entity3 uniformly recover and therefore primary surgical exploration seems unnecessary. In high energy @entity3 , neurotmesis or severe contusion must be expected. In this case nerve recovery is unfavourable and the @entity0 should be informed of the poor prognosis and the need of tendon transfers.

title: @entity4 associated with humeral shaft @entity3 . Is the energy of XXXX a prognostic factor?

answer: @entity2


abstract: In a prospective, randomised trial, we compared the use of three Ullevaal hip screws with that of two Hansson hook-pins in 278 @entity0 with @entity4 . Background factors were similar in both groups. Follow-up was for two years. There were no significant differences between the groups in length of time of surgery, hospital stay, general complications, mortality, @entity2 or walking ability. Likewise, the rates of early failure of fixation, nonunion, and the need for reoperation did not differ significantly between the groups. The use of hook-pins was associated with less drill penetrations of the femoral head during surgery (odds ratio 2.6, p = 0.05) and a lower incidence of @entity1 of the femoral head (odds ratio 3.5, p = 0.04). There was a strong relationship between poor reduction and fixation of the @entity3 and subsequent reoperation (p = 0.0005 and p = 0.0001, respectively). Likewise, peroperative drill penetration of the femoral head was associated with a greater risk of reoperation (p = 0.038). Both methods gave favourable results. In total, 22% of the @entity0 needed a major reoperation (usually hemiarthroplasty), while in 7% of the cases the fixation device needed to be removed. Osteosynthesis as the sole method for operation of all @entity4 was thus successful in 78% of @entity0 . With selective treatment most of the remaining @entity0 would have benefited if treated by a primary arthroplasty. Accurate selection requires the development of better prognostic methods.

title: Fixation of XXXX . A prospective, randomised trial of three Ullevaal hip screws versus two Hansson hook-pins.

answer: @entity4


abstract: In the present study we tested 13 @entity0 with @entity1 ( @entity1 ) and 24 typically developing @entity0 (7-12 years old) in a unimanual and bimanual motor planning task. We focused on two research questions: (1) How does motor planning develop in @entity0 with and without @entity1 ? and (2) Is motor planning facilitated when the task is performed with both hands? @entity0 had to grasp one or two vertical oriented cylinder(s) and transport it/them to a platform that had different heights. As a measure of motor planning, we registered the height at which @entity0 grasped the cylinder. Here, anticipation of grasp height upon the height of the upcoming target(s) is reflective of proper forward motor planning as it leads to a comfortable posture at the end of the task. In the unimanual task the typically developing @entity0 showed a significant grasp height effect, which increased with age. In contrast, no grasp height effect, or age related changes therein were found for the @entity0 with @entity1 , suggesting a compromised development of motor planning in these @entity0 . Interestingly, when @entity0 had to transport one cylinder to a high shelf and one cylinder to a low shelf, the more affected hand of the @entity1 children clearly anticipated the grasp height to the upcoming target height. The less affected hand did not show such anticipation. Taken collectively, these findings suggest a delayed or compromised development of motor planning in @entity0 with @entity1 compared to typically developing @entity0 . At the same time, the facilitated motor planning of the more affected arm in the bimanual task offers a valuable entry point for intervention to improve motor planning in @entity1 .

title: Typical and atypical ( XXXX ) development of unimanual and bimanual grasp planning.

answer: @entity1


abstract: OBJECTIVES: We evaluated the long-term results of @entity4 treated with coracoclavicular fixation using a cancellous screw. METHODS: Coracoclavicular fixation was performed using the modified Bosworth technique in 32 @entity0 (24 males, 8 females; mean age 35 years; range 19 to 58 years) with @entity4 . According to the Rockwood classification, seven @entity0 had type III, nine @entity0 had type IV, 13 @entity0 had type V, and three @entity0 had @entity4 . Following repair of the coracoclavicular ligament, fixation was performed with a cancellous screw in all but two @entity0 in whom a cortical screw was used. These two @entity0 developed redislocation due to screw cut out and underwent reoperation with cancellous screw fixation and were not included in the final assessments. The screws were removed under local anesthesia after eight weeks postoperatively. The @entity0 were evaluated for cosmetic appearance, functional status, @entity1 , localized tenderness, articular range of motion, and with the functional Constant scoring system. The mean follow up was 3.1 years (range 1 to 8 years). RESULTS: The mean Constant score was 98 (range 92 to 100). The results were excellent in 26 @entity0 (86.7%) and good in four @entity0 (13.3%). There was subluxation of the acromioclavicular joint in one @entity0 (3.3%). The alignment of the acromioclavicular joint was normal in the remaining @entity0 . None of the @entity0 showed @entity2 . All @entity0 were @entity1 -free and achieved full range of motion. CONCLUSION: With ease of application, low complication rate, and low rate of @entity3 , the modified Bosworth technique is an effective surgical method in providing satisfactory shoulder function in @entity4 .

title: Coracoclavicular ligament repair and screw fixation in XXXX .

answer: @entity4


abstract: OBJECTIVE: To determine whether @entity4 modulates acquisition of sleep-wake cycling in term neonates with moderate to severe @entity5 ( @entity5 ) and the relationship to outcome. STUDY DESIGN: Twenty-nine term @entity0 with moderate to severe @entity5 treated with selective head cooling were evaluated. All were monitored with amplitude-integrated electroencephalography during and video electroencephalography immediately after @entity4 for >= 72 hours. Electroencephalograpic data were analyzed for background and sleep-wake cycling. Abnormal outcome included @entity1 or severe @entity2 >= 18 months. RESULTS: Acquisition of sleep-wake cycling was noted in nine @entity0 by 72 hours, in 13 by 96 hours, 19 by 120 hours, and 22 by 144 hours. Presence of sleep-wake cycling was associated with normal outcome, that is, 14 of 22 (64%), versus abnormal outcome, that is, none of seven without sleep-wake cycling (P = .006). The presence of sleep-wake cycling by 120 hours had a positive predictive value of 68% and negative predictive value of 90%. Magnetic resonance imaging abnormalities were related to @entity3 . CONCLUSIONS: Although @entity3 is markedly delayed in term neonates with moderate to severe @entity5 treated with @entity4 , approximately 65% with acquisition of cycling have a normal outcome. Sleep-wake cycling is an important additional tool for assessing recovery in term @entity0 with moderate to severe @entity5 treated with @entity4 .

title: Delayed XXXX with favorable outcome in hypothermic-treated neonates with encephalopathy.

answer: @entity3


abstract: NFKB: is a pleiotropic transcription factor that participates in the induction of various cellular and viral genes (for a review, see refs. 1 and 2). The principal form of this active complex is composed of two polypeptides, @entity4 (recently renamed @entity4 ) and @entity1 (recently renamed @entity1 ) (3, 4). Both of these sub-units belong to the rel famtly of transcription factors with homology in the @entity0 terminus (5, 6). Since the original identification of these factors, several others have been identified in this family of transcription factors: @entity7 , @entity2 , @entity3 , @entity6 , dorsal, @entity5 , and @entity1 (1). The NF-kheterodimer is associated in the cytoplasm with the IkB subunit, which sequesters this factor in an inactive state (7). On activation by various stimuli, the IkB subunit separates from the active NFheterodimer, and the active complex is translocated to the nucleus where it binds to its nuclear DNA target sequence (Fig. 1). The principal cause for disassociation of IkB from NFis phosphorylation (8), but it may involve proteolysis of IkB (9) Several autoregulatory loops have been proposed for the involvement of NF-kB in the regulation of the inhibitor IkB. Furthermore, NF-kB has been shown to regulate the transcription of IkB and @entity1 (10-12). Fig. 1. NF-K: B transcription factor. This figure depicts the basis for the function of the NF-K: B transcription factor. The principal form of the NF-K: B transcription complex is as a heterodimer composed of the two subunits: @entity4 and @entity1 . The inactive complex is sequestered in the cytoplasm associated with the inhibitor protein, IK: B. On activation, the IK: B protein separates from the active complex through a mechanism involving the phosphorylation and proteolysis Of IK: B. The active NF-K: B complex is then translocated to the nucleus where it binds DNA in a sequence-specific manner and interacts with the transcriptional machinery to modulate the rate of transcription of target genes.

title: Antisense XXXX in Cancer.

answer: @entity4


abstract: PURPOSE: A collaborative meta-analysis was performed to clarify the relative effects on relapse and survival of different types of therapies directed at the CNS in childhood @entity2 . MATERIALS AND METHODS: Data were sought for each individual @entity0 in all trials started in or before 1993 that included unconfounded randomized comparisons of such treatments. Log-rank survival analyses were performed for each trial, and overall results for groups of trials addressing similar questions were obtained from the totals of the observed minus expected number of events and their variances. RESULTS: Radiotherapy and long-term intrathecal therapy gave similar outcomes, with no significant difference in event-free survival despite random assignment of treatment to 2,848 @entity0 , 1,001 of whom suffered relapse or @entity1 . Intravenous @entity3 reduced non-CNS rather than CNS relapses, and hence, the addition of intravenous @entity3 to a treatment regimen including radiotherapy or long-term intrathecal therapy improved event-free survival, with a 17% reduction in the event rate (95% confidence interval, 6% to 27%; P =.003). The event-free survival at 10 years in these trials was 61.9% without intravenous @entity3 and 68.1% with intravenous @entity3 . There was no significant difference in survival (14% @entity1 rate reduction; P =.09). There were insufficient randomly assigned @entity0 to adequately address other questions, such as effect of different doses. No evidence was found of differences, between trials or between subgroups of different types of @entity0 , in the relative effects of treatment. CONCLUSION: Radiotherapy can be replaced by long-term intrathecal therapy. Intravenous @entity3 gives some additional benefit by reducing non-CNS relapses.

title: CNS-directed therapy for childhood XXXX : @entity2 Collaborative Group overview of 43 randomized trials.

answer: @entity2


abstract: PURPOSE: A collaborative meta-analysis was performed to clarify the relative effects on relapse and survival of different types of therapies directed at the CNS in childhood @entity2 . MATERIALS AND METHODS: Data were sought for each individual @entity0 in all trials started in or before 1993 that included unconfounded randomized comparisons of such treatments. Log-rank survival analyses were performed for each trial, and overall results for groups of trials addressing similar questions were obtained from the totals of the observed minus expected number of events and their variances. RESULTS: Radiotherapy and long-term intrathecal therapy gave similar outcomes, with no significant difference in event-free survival despite random assignment of treatment to 2,848 @entity0 , 1,001 of whom suffered relapse or @entity1 . Intravenous @entity3 reduced non-CNS rather than CNS relapses, and hence, the addition of intravenous @entity3 to a treatment regimen including radiotherapy or long-term intrathecal therapy improved event-free survival, with a 17% reduction in the event rate (95% confidence interval, 6% to 27%; P =.003). The event-free survival at 10 years in these trials was 61.9% without intravenous @entity3 and 68.1% with intravenous @entity3 . There was no significant difference in survival (14% @entity1 rate reduction; P =.09). There were insufficient randomly assigned @entity0 to adequately address other questions, such as effect of different doses. No evidence was found of differences, between trials or between subgroups of different types of @entity0 , in the relative effects of treatment. CONCLUSION: Radiotherapy can be replaced by long-term intrathecal therapy. Intravenous @entity3 gives some additional benefit by reducing non-CNS relapses.

title: CNS-directed therapy for childhood @entity2 : XXXX Collaborative Group overview of 43 randomized trials.

answer: @entity2


abstract: IMMUNOLOGICAL AND MICROBIOLOGICAL ASPECTS OF DIABETIC FOOT INFECTIONS: @entity1 @entity0 are at increased risk of severe @entity2 . @entity5 are reasonable and due to altered specific and unspecific cellular immune responses. Analysis of epidemiology and microbial pathogenicity shows that staphylococci seem to be predestined to induce such @entity3 . @entity4 and coagulase-negative staphylococci are able to adhere to the wound ground by a sequela of mechanisms. Initial bacterial adherence is due to hydrophobicity, ion exchanges, and specific binding of bacterial adhesion molecules to cellular receptors. Moreover, staphylococci secrete polysaccharides which form a biofilm together with multilayer cell clusters. The highly structured communities within a biofilm are resistant to distinct immunoeffectors and have a decreased susceptibility to antibiotics in vivo. ASPECTS OF ANTIBIOTIC THERAPY: Assessing the severity of an infection is essential to selecting an antibiotic regimen, the mode of drug administration, and the duration of therapy. Regimens for severe and @entity3 are broader spectrum and often intravenously to obtain high drug concentrations immediately. Infections of the bone often require an antibiotic therapy for > 4 weeks, while a 1- to 2-week therapy for mild to moderate @entity3 has been found to be effective. CONCLUSIONS: Because of the tremendous progress in diagnostics and therapy of @entity1 , infectious complications can be successfully treated by appropriate wound care, metabolic control, and early surgical and antibiotic intervention. Bacterial biofilms involved into @entity3 are new aspects currently not visualized by clinical therapy. Besides the classic antimicrobial therapy, new concepts of an enzymatic therapy or the inhibition of bacterial "communication" (quorum sensing) are in progress and the hope for the future.

title: [Microbiological aspects and antibiotic therapy of XXXX ].

answer: @entity1


abstract: This investigation was made with special reference to the effect of the combined use of @entity5 ( @entity5 ) inhibitor @entity9 dithiocarbamate( @entity8 ) and @entity3 on the expression of Matrix metalloproteinases ( @entity4 ) and its inhibitor @entity6 , and on the proliferation and invasion of @entity1 @entity0 cell line MCF-7. The MCF-7 cells were treated with PDTC and @entity3 . The effect on proliferation was evaluated by @entity2 assay. The cell cycle was analyzed by flow cytometry. Western blot was used to determine the change of @entity7 , @entity4 and @entity6 expression in MCF-7 cells after treatment. RT-PCR was used to detect @entity5 @entity7 mRNA expression. The invasion ability of MCF-7 cells was tested by the invasion, migration and cell adhesion assay. The cell growth was significantly slowed down and the cell cycle was arrested at G0/G1 phase after the combined treatment. The expression of @entity7 and @entity4 was down-regulated and the invasion ability of MCF-7 cells was decreased after the combined treatment. In conclusion,PDTC combined with @entity3 effectively inhibited cell proliferation, induced cell cycle arrest, and decreased cell invasion ability of @entity0 MCF-7 cells. The mechanism may be associated with the inhibiting effect of PDTC on the @entity5 -related gene expression.

title: [Effect of combined use of PDTC and @entity3 on proliferation and invasion of @entity1 XXXX cell line MCF-7].

answer: @entity0


abstract: This investigation was made with special reference to the effect of the combined use of @entity5 ( @entity5 ) inhibitor @entity9 dithiocarbamate( @entity8 ) and @entity3 on the expression of Matrix metalloproteinases ( @entity4 ) and its inhibitor @entity6 , and on the proliferation and invasion of @entity1 @entity0 cell line MCF-7. The MCF-7 cells were treated with PDTC and @entity3 . The effect on proliferation was evaluated by @entity2 assay. The cell cycle was analyzed by flow cytometry. Western blot was used to determine the change of @entity7 , @entity4 and @entity6 expression in MCF-7 cells after treatment. RT-PCR was used to detect @entity5 @entity7 mRNA expression. The invasion ability of MCF-7 cells was tested by the invasion, migration and cell adhesion assay. The cell growth was significantly slowed down and the cell cycle was arrested at G0/G1 phase after the combined treatment. The expression of @entity7 and @entity4 was down-regulated and the invasion ability of MCF-7 cells was decreased after the combined treatment. In conclusion,PDTC combined with @entity3 effectively inhibited cell proliferation, induced cell cycle arrest, and decreased cell invasion ability of @entity0 MCF-7 cells. The mechanism may be associated with the inhibiting effect of PDTC on the @entity5 -related gene expression.

title: [Effect of combined use of PDTC and XXXX on proliferation and invasion of @entity1 @entity0 cell line MCF-7].

answer: @entity3


abstract: This investigation was made with special reference to the effect of the combined use of @entity5 ( @entity5 ) inhibitor @entity9 dithiocarbamate( @entity8 ) and @entity3 on the expression of Matrix metalloproteinases ( @entity4 ) and its inhibitor @entity6 , and on the proliferation and invasion of @entity1 @entity0 cell line MCF-7. The MCF-7 cells were treated with PDTC and @entity3 . The effect on proliferation was evaluated by @entity2 assay. The cell cycle was analyzed by flow cytometry. Western blot was used to determine the change of @entity7 , @entity4 and @entity6 expression in MCF-7 cells after treatment. RT-PCR was used to detect @entity5 @entity7 mRNA expression. The invasion ability of MCF-7 cells was tested by the invasion, migration and cell adhesion assay. The cell growth was significantly slowed down and the cell cycle was arrested at G0/G1 phase after the combined treatment. The expression of @entity7 and @entity4 was down-regulated and the invasion ability of MCF-7 cells was decreased after the combined treatment. In conclusion,PDTC combined with @entity3 effectively inhibited cell proliferation, induced cell cycle arrest, and decreased cell invasion ability of @entity0 MCF-7 cells. The mechanism may be associated with the inhibiting effect of PDTC on the @entity5 -related gene expression.

title: [Effect of combined use of PDTC and @entity3 on proliferation and invasion of XXXX @entity0 cell line MCF-7].

answer: @entity1


abstract: AIM: To probe the pathological biological characteristics of @entity2 ( @entity2 ) by the ultrasound-guided aspiration biopsy and assess the clinical application value of this method. METHODS: The biopsy and DNA analysis by flow cytometry (FCM) were taken in 46 cases with @entity2 nodules, including 26 cases and 20 cases with nodules < or =3 cm and >3 cm in diameters respectively, and 12 cases with intrahepatic benign hyperplastic nodules. They were taken in 22 cases of 46 cases with @entity2 before and after the therapy. Fine-needles and automatic histological incised biopsy needles were used. The fresh biopsy tissue was produced into the single cell suspension, which was sent for DNA detection and ratio analysis of cell period. The ratio of each DNA period of cell proliferation of each group was calculated and compared with each other. The DNA @entity3 ( @entity3 ) and apoptosis cell peak were observed and their percentages were calculated. RESULTS: The ratios of S and G(2)/M periods of DNA, which reflect cell hyperproliferation, in the group with @entity1 >3 cm in diameter were markedly higher than those of the group with @entity2 nodules < or =3 cm in diameter and the group with the benign hyperplastic nodules (P<0.01 except A:B of S period, P<0.05). The ratios of the middle group were also apparently higher than those of the latter group (P<0.01). The ratio of DNA @entity3 of 46 cases with @entity2 nodules was 34.8 % (16/46). None of the cases with the intrahepatic hyperplastic nodules appeared @entity3 . The DNA @entity3 appeared more apparently with the growth of the @entity0 . The @entity3 ratio of the group with @entity0 >3 cm in diameter was 55 % (11/20), markedly higher than that of the group with @entity0 < or =3 cm in diameter which was 19.2 % (5/26) (P<0.01). The FCM DNA analysis of 22 specimens of @entity1 tissue before therapy showed that the @entity3 peaks appeared in 5 cases (22.7 %). The ratio of G(1) period rose after therapy while the S period and G(2)/M ratios fell (P<0.01). The @entity3 peak disappeared in the 5 cases after the therapy, while the apoptosis peaks in 12 cases (54.5 %) appeared. CONCLUSION: Addition to supply the information of the pathological morphology of the @entity0 , the ultrasound-guided fine-needle aspiration tissue could be sent for FCM DNA analysis to comprehend its pathological biological characteristics. This can not only provide the clinic the reliable information about the occurrence, development, diagnosis, curative effect and prognosis of @entity0 but also supply biological information for clinic to choose therapeutic schemes.

title: Biological characteristics of XXXX by ultrasound-guided aspiration biopsy and its clinical application.

answer: @entity2


abstract: The clinical and pathologic features of 60 @entity6 were reviewed in an attempt to evaluate the utility of histopathologic evaluation in predicting the prognosis for these @entity2 . Fifty-five @entity2 were benign, and five were malignant, characterized either by histologically proved @entity1 or by extensive local invasion. The prevalence of all parameters studied was compared between the benign and malignant groups. Three differences were observed between the benign and @entity2 . The @entity2 were usually larger, had extensive areas of @entity3 , and were composed of small cells. In agreement with the results of previous investigations, the morphologic criteria generally used to predict the behavior of @entity2 , i.e., nuclear atypia, capsular and vascular invasion, and mitotic activity, were of little value in predicting the behavior of @entity6 . @entity2 , all of which had membrane-bound, cytoplasmic granules, were examined electron microscopically. A minority of these @entity2 fit the classic descriptions of " @entity4 " and "epinephrine" granules reported in the literature, while the majority of the granules had features of both types, precluding definitive classification. As a result of these observations, the currently accepted criteria of @entity4 and @entity5 granules were questioned. A review of the literature cast further doubt on the existence of a correlation between granule content and morphology. Both of the @entity0 with locally invasive @entity2 were alive and well eight and 28 years following diagnosis and radical surgery. In contrast, the @entity0 with histologically proved distant @entity1 died within one year of diagnosis. These observations suggest that locally invasive @entity2 may not have the same dismal prognosis as @entity6 that have metastasized.

title: XXXX : a clinicopathologic review of 60 cases.

answer: @entity6


abstract: We report on the use of penile tumescence assessment to diagnose a paraphiliac client who was in denial about his problem. An 18-year-old male was accused of sexually assaulting a 4-year-old @entity0 using physical restraint and vaginal penetration with a finger. During a @entity1 evaluation requested by the court, a comprehensive psychosexual assessment revealed that the subject was in denial about clarification of the paraphiliac experience. Penile tumescence under distinct visual stimulus was evaluated with electrobioimpedence volumetric assessment using @entity0 and adult female pictures in separate time frames. Both types of stimuli evoked arousal responses. However, @entity0 female stimuli demonstrated stronger responses than did adult female ones. Deviant sexual interest in @entity0 as well as a diagnosis of @entity3 was implied. Paraphiliac clients tend to be in denial toward psychosexual assessment which limits the interpretation of its results. Penile tumescence assessment may be more reliable than psychosexual assessment alone for detecting and diagnosing @entity2 . Further study is warranted in order to aid in more accurate diagnoses of @entity2 .

title: Penile tumescence assessment used for a diagnosis of @entity2 : a XXXX case report.

answer: @entity3


abstract: We report on the use of penile tumescence assessment to diagnose a paraphiliac client who was in denial about his problem. An 18-year-old male was accused of sexually assaulting a 4-year-old @entity0 using physical restraint and vaginal penetration with a finger. During a @entity1 evaluation requested by the court, a comprehensive psychosexual assessment revealed that the subject was in denial about clarification of the paraphiliac experience. Penile tumescence under distinct visual stimulus was evaluated with electrobioimpedence volumetric assessment using @entity0 and adult female pictures in separate time frames. Both types of stimuli evoked arousal responses. However, @entity0 female stimuli demonstrated stronger responses than did adult female ones. Deviant sexual interest in @entity0 as well as a diagnosis of @entity3 was implied. Paraphiliac clients tend to be in denial toward psychosexual assessment which limits the interpretation of its results. Penile tumescence assessment may be more reliable than psychosexual assessment alone for detecting and diagnosing @entity2 . Further study is warranted in order to aid in more accurate diagnoses of @entity2 .

title: Penile tumescence assessment used for a diagnosis of XXXX : a @entity3 case report.

answer: @entity2


abstract: OBJECTIVES: This study attempted to determine factors that help currently employed @entity0 with @entity3 , @entity1 or @entity4 to continue working. METHODS: This was a qualitative study that used three concept-mapping sessions. Sixty-nine @entity0 ( @entity3 21, @entity1 23, and @entity4 25) were recruited from the @entity0 records of the rheumatology, @entity1 , and audiology outpatients of the @entity6 ( @entity6 ), Amsterdam, and referrals from occupational physicians and @entity0 associations. An @entity5 consultant, a @entity1 consultant, and an audiologist screened the @entity0 for the used illness inclusion criteria. A researcher screened the @entity0 for the inclusion criteria of age and work. RESULTS: The main factors enabling employees to continue working were ability to cope with the illness, support from management and colleagues, adequate work conditions, support of @entity0 organizations and society, support of medical professionals and facilities, and benefits. The three groups of employees rated the priority of these factors differently. For the employees with @entity3 , the support of management was the most important, followed by self-acceptance, self-efficacy, and professional advice on how to cope at work. For those with @entity1 , self-acceptance, self-care, and support from management, colleagues and health professionals were the most important. For employees with @entity4 , being well informed about hearing equipment, reimbursement, and self-acceptance were the most important. A topic list was developed that can be used by health professionals as a guideline for exploring the work-related problems of @entity0 with a @entity2 . CONCLUSION: The results provide an understanding of the needs chronically ill employees have at work and the areas to which health professionals need to pay attention.

title: What employees with @entity3 , @entity1 and XXXX need to cope at work.

answer: @entity4


abstract: OBJECTIVES: This study attempted to determine factors that help currently employed @entity0 with @entity3 , @entity1 or @entity4 to continue working. METHODS: This was a qualitative study that used three concept-mapping sessions. Sixty-nine @entity0 ( @entity3 21, @entity1 23, and @entity4 25) were recruited from the @entity0 records of the rheumatology, @entity1 , and audiology outpatients of the @entity6 ( @entity6 ), Amsterdam, and referrals from occupational physicians and @entity0 associations. An @entity5 consultant, a @entity1 consultant, and an audiologist screened the @entity0 for the used illness inclusion criteria. A researcher screened the @entity0 for the inclusion criteria of age and work. RESULTS: The main factors enabling employees to continue working were ability to cope with the illness, support from management and colleagues, adequate work conditions, support of @entity0 organizations and society, support of medical professionals and facilities, and benefits. The three groups of employees rated the priority of these factors differently. For the employees with @entity3 , the support of management was the most important, followed by self-acceptance, self-efficacy, and professional advice on how to cope at work. For those with @entity1 , self-acceptance, self-care, and support from management, colleagues and health professionals were the most important. For employees with @entity4 , being well informed about hearing equipment, reimbursement, and self-acceptance were the most important. A topic list was developed that can be used by health professionals as a guideline for exploring the work-related problems of @entity0 with a @entity2 . CONCLUSION: The results provide an understanding of the needs chronically ill employees have at work and the areas to which health professionals need to pay attention.

title: What employees with XXXX , @entity1 and @entity4 need to cope at work.

answer: @entity3


abstract: OBJECTIVES: This study attempted to determine factors that help currently employed @entity0 with @entity3 , @entity1 or @entity4 to continue working. METHODS: This was a qualitative study that used three concept-mapping sessions. Sixty-nine @entity0 ( @entity3 21, @entity1 23, and @entity4 25) were recruited from the @entity0 records of the rheumatology, @entity1 , and audiology outpatients of the @entity6 ( @entity6 ), Amsterdam, and referrals from occupational physicians and @entity0 associations. An @entity5 consultant, a @entity1 consultant, and an audiologist screened the @entity0 for the used illness inclusion criteria. A researcher screened the @entity0 for the inclusion criteria of age and work. RESULTS: The main factors enabling employees to continue working were ability to cope with the illness, support from management and colleagues, adequate work conditions, support of @entity0 organizations and society, support of medical professionals and facilities, and benefits. The three groups of employees rated the priority of these factors differently. For the employees with @entity3 , the support of management was the most important, followed by self-acceptance, self-efficacy, and professional advice on how to cope at work. For those with @entity1 , self-acceptance, self-care, and support from management, colleagues and health professionals were the most important. For employees with @entity4 , being well informed about hearing equipment, reimbursement, and self-acceptance were the most important. A topic list was developed that can be used by health professionals as a guideline for exploring the work-related problems of @entity0 with a @entity2 . CONCLUSION: The results provide an understanding of the needs chronically ill employees have at work and the areas to which health professionals need to pay attention.

title: What employees with @entity3 , XXXX and @entity4 need to cope at work.

answer: @entity1


abstract: Previous studies have reported an increased incidence of complications following neonatal @entity1 ( @entity1 ) in @entity0 . The incidence and natural history of postoperative hydrocele in such cases has not been described. A prospective follow-up study of a consecutive series of male @entity0 weighing less than 3 kg at the time of @entity1 was undertaken. Regular follow-up examinations were scheduled for at least 1 year. Thirty-eight @entity0 weighing less than 3 kg underwent @entity1 during an 18-month period. One subsequently died from complications of @entity3 . Complete follow-up data were available for 29/37 (78%) @entity0 , yielding a total of 46 IHs. There were 2 recurrent @entity2 (4%), 2 unequivocally atrophic testes (4%), and 1 iatrogenic testicular ascent (2%). Five ipsilateral hydroceles complicated the postoperative course of 4 @entity0 (14% of @entity0 , 11% of herniotomies). Two of these were explored, but in neither case was a recurrent/residual patent processus vaginalis found. One hydrocele was aspirated without recurrence, and the remaining 2 resolved spontaneously. The complication rate in small @entity0 undergoing neonatal @entity1 is significantly higher than in older @entity0 . The presence of a hydrocele after neonatal @entity1 may simply reflect the accumulation of fluid in the distal hernia sac and, provided there is no evidence of a recurrent @entity1 , an expectant approach is recommended.

title: A prospective study of neonatal XXXX : the problem of the postoperative hydrocele.

answer: @entity1


abstract: BACKGROUND: @entity4 ( @entity4 ) is the leading cause of @entity6 in @entity0 with @entity7 ( @entity7 ). Disregulation of apoptosis within the vessel wall and upregulation of the @entity2 ( @entity2 ) system contribute to the development of @entity8 . Cross-sectional studies have suggested that elevated plasma levels of the soluble form of Fas (sFas) are associated with @entity4 . However, the role of sFas and sFas-L in predicting future cardiovascular events has yet to be defined. METHODS: We evaluated the role of plasma sFas and sFas-L levels as predictors of @entity4 in a prospective cohort of 107 chronic hemodialysis @entity0 . RESULTS: During the study period (27 months), 53 @entity0 (49.5%) presented with at least one cardiovascular end point. On univariate analysis, baseline sFas levels were significantly associated with the occurrence of cardiovascular end points, whereas sFas-L levels were not. Using Cox proportional hazards, increased sFas levels were associated with a significantly greater risk for cardiovascular end points (P = 0.03). This effect was independent of baseline @entity4 history, classic risk factors for @entity8 ( @entity1 , @entity9 , @entity5 , and smoking), and markers of @entity3 (C-reactive protein [CRP], soluble intercellular adhesion molecule-1). Increased CRP levels also were associated with cardiovascular end points (P = 0.04). In addition, increased cardiovascular mortality was found in @entity0 in the highest sFas tertile compared with those in the lowest tertile (27.8% versus 8.6%; P = 0.04). CONCLUSION: Increased plasma sFas levels are predictive of future @entity4 . These results suggest that sFas is a novel and independent predictor of active @entity8 in @entity0 with @entity7 .

title: Soluble Fas: a novel predictor of XXXX in dialysis @entity0 .

answer: @entity8


abstract: BACKGROUND: @entity4 ( @entity4 ) is the leading cause of @entity6 in @entity0 with @entity7 ( @entity7 ). Disregulation of apoptosis within the vessel wall and upregulation of the @entity2 ( @entity2 ) system contribute to the development of @entity8 . Cross-sectional studies have suggested that elevated plasma levels of the soluble form of Fas (sFas) are associated with @entity4 . However, the role of sFas and sFas-L in predicting future cardiovascular events has yet to be defined. METHODS: We evaluated the role of plasma sFas and sFas-L levels as predictors of @entity4 in a prospective cohort of 107 chronic hemodialysis @entity0 . RESULTS: During the study period (27 months), 53 @entity0 (49.5%) presented with at least one cardiovascular end point. On univariate analysis, baseline sFas levels were significantly associated with the occurrence of cardiovascular end points, whereas sFas-L levels were not. Using Cox proportional hazards, increased sFas levels were associated with a significantly greater risk for cardiovascular end points (P = 0.03). This effect was independent of baseline @entity4 history, classic risk factors for @entity8 ( @entity1 , @entity9 , @entity5 , and smoking), and markers of @entity3 (C-reactive protein [CRP], soluble intercellular adhesion molecule-1). Increased CRP levels also were associated with cardiovascular end points (P = 0.04). In addition, increased cardiovascular mortality was found in @entity0 in the highest sFas tertile compared with those in the lowest tertile (27.8% versus 8.6%; P = 0.04). CONCLUSION: Increased plasma sFas levels are predictive of future @entity4 . These results suggest that sFas is a novel and independent predictor of active @entity8 in @entity0 with @entity7 .

title: Soluble Fas: a novel predictor of @entity8 in dialysis XXXX .

answer: @entity0


abstract: A 71-year-old @entity0 was admitted to our hospital because of systemic @entity2 and exertional @entity9 . Chest radiographs revealed infiltrative shadows in both lung fields, @entity8 , and @entity12 . Seven years before, he had undergone gastric surgery for a gastric ulcer with @entity5 . In the pathologic diagnosis based on the percutaneous lung biopsy, hyalinizing @entity6 was suspected. For a more thorough diagnosis, the @entity0 was subjected to an open lung biopsy, and the final diagnosis was low-grade @entity11 (mucosa-associated lymphoid tissue) type. Gallium scintigraphy showed accentuated accumulation in the left neck and @entity10 was present. Histologic re-examination of the resected stomach revealed infiltration of centrocyte-like cells and lymphoepithelial lesions, compatible with the pathologic features of @entity7 . We considered that the @entity4 and the pulmonary, pleural, and @entity3 of @entity7 had occurred seven years apart in this case. Thyroid hormone replacement and @entity13 therapy improved the symptoms and @entity1 size by 73%. @entity7 tend to remain localized for a long period. The multiorgan involvement seen in this case is rather rare.

title: [A case of pulmonary low-grade XXXX (MALT type) presenting seven years after gastric lymphoma resection].

answer: @entity11


abstract: This research investigated the prevalence of @entity6 ( @entity6 ), @entity4 ( @entity4 ) and @entity5 in a midwestern university population following the terrorist attacks on September 11, 2001, in New York City and Washington, DC. Three-hundred five subjects volunteered to complete a questionnaire which measured nine areas of psychosocial functioning which included demographics, personality, @entity6 , @entity4 , prior traumatic experiences, @entity3 and drug use, @entity2 history and treatment, and current attitudes towards government, religion, the economy, and how @entity0 were affected by the events. The @entity0 lived in a large urban city over which United Flight 93 circled before crashing in Pennsylvania due to terrorist attacks. The subjects were forced to evacuate their university and city due to attacks on New York and errant United Flight 93. The study also replicated the first two national studies on @entity6 prevalence (Schuster, et al., 2002; Galea, et al., 2002). The results found a prevalence rate of 5.9% for probable @entity6 , matching identically previous national surveys. There were higher levels of @entity6 and @entity4 for females, those with less education and who were single or unmarried, and those who had a prior history of mental health problems or psychological @entity1 . @entity6 and @entity4 were associated with higher levels of @entity3 and drug use since September 11. Relations to active duty military personnel appear to moderate the perception of threat, suggesting the importance of affiliative kinship patterns to coping with stress. Finally, the concept of geographic and psychological proximity to the 'zone of danger' is discussed.

title: PSTD, major XXXX , and @entity5 following September 11, 2001, in a midwestern university population.

answer: @entity4


abstract: This research investigated the prevalence of @entity6 ( @entity6 ), @entity4 ( @entity4 ) and @entity5 in a midwestern university population following the terrorist attacks on September 11, 2001, in New York City and Washington, DC. Three-hundred five subjects volunteered to complete a questionnaire which measured nine areas of psychosocial functioning which included demographics, personality, @entity6 , @entity4 , prior traumatic experiences, @entity3 and drug use, @entity2 history and treatment, and current attitudes towards government, religion, the economy, and how @entity0 were affected by the events. The @entity0 lived in a large urban city over which United Flight 93 circled before crashing in Pennsylvania due to terrorist attacks. The subjects were forced to evacuate their university and city due to attacks on New York and errant United Flight 93. The study also replicated the first two national studies on @entity6 prevalence (Schuster, et al., 2002; Galea, et al., 2002). The results found a prevalence rate of 5.9% for probable @entity6 , matching identically previous national surveys. There were higher levels of @entity6 and @entity4 for females, those with less education and who were single or unmarried, and those who had a prior history of mental health problems or psychological @entity1 . @entity6 and @entity4 were associated with higher levels of @entity3 and drug use since September 11. Relations to active duty military personnel appear to moderate the perception of threat, suggesting the importance of affiliative kinship patterns to coping with stress. Finally, the concept of geographic and psychological proximity to the 'zone of danger' is discussed.

title: PSTD, major @entity4 , and XXXX following September 11, 2001, in a midwestern university population.

answer: @entity5


abstract: STUDY DESIGN: Case-series study. OBJECTIVE: To describe the clinical presentation, characteristic findings of imaging studies, and treatment of @entity4 caused by foraminal @entity6 in @entity3 . BACKGROUND. @entity1 in @entity3 are relatively rare, with a limited number of systemic reports. METHODS: Six @entity0 with @entity4 caused by foraminal @entity6 in @entity3 were treated. The @entity0 were all @entity0 with a mean age of 69 years and mean @entity3 duration of 15 years. The medical records and imaging studies of all @entity0 were reviewed. RESULTS: The affected nerve roots were L4 in four @entity0 and L3 in two @entity0 . Foraminal @entity6 was not demonstrated in magnetic resonance images in four of the six @entity0 . Selective radiculography with nerve @entity5 reproduced @entity2 , manifested blocking effect, and demonstrated compression of the nerve root by the superior articular process of the lower vertebra in all @entity0 . Conservative treatment was performed on one @entity0 , and surgery was conducted for the rest of the five @entity0 ; @entity4 was improved in all @entity0 . CONCLUSIONS: Lumbar foraminal @entity6 is a characteristic pathology of @entity3 , and should be kept in mind in the diagnosis of @entity4 . Selective radiculography is useful in the diagnosis of affected nerve roots.

title: @entity4 caused by foraminal XXXX in @entity3 .

answer: @entity6


abstract: STUDY DESIGN: Case-series study. OBJECTIVE: To describe the clinical presentation, characteristic findings of imaging studies, and treatment of @entity4 caused by foraminal @entity6 in @entity3 . BACKGROUND. @entity1 in @entity3 are relatively rare, with a limited number of systemic reports. METHODS: Six @entity0 with @entity4 caused by foraminal @entity6 in @entity3 were treated. The @entity0 were all @entity0 with a mean age of 69 years and mean @entity3 duration of 15 years. The medical records and imaging studies of all @entity0 were reviewed. RESULTS: The affected nerve roots were L4 in four @entity0 and L3 in two @entity0 . Foraminal @entity6 was not demonstrated in magnetic resonance images in four of the six @entity0 . Selective radiculography with nerve @entity5 reproduced @entity2 , manifested blocking effect, and demonstrated compression of the nerve root by the superior articular process of the lower vertebra in all @entity0 . Conservative treatment was performed on one @entity0 , and surgery was conducted for the rest of the five @entity0 ; @entity4 was improved in all @entity0 . CONCLUSIONS: Lumbar foraminal @entity6 is a characteristic pathology of @entity3 , and should be kept in mind in the diagnosis of @entity4 . Selective radiculography is useful in the diagnosis of affected nerve roots.

title: XXXX caused by foraminal @entity6 in @entity3 .

answer: @entity4


abstract: STUDY DESIGN: Case-series study. OBJECTIVE: To describe the clinical presentation, characteristic findings of imaging studies, and treatment of @entity4 caused by foraminal @entity6 in @entity3 . BACKGROUND. @entity1 in @entity3 are relatively rare, with a limited number of systemic reports. METHODS: Six @entity0 with @entity4 caused by foraminal @entity6 in @entity3 were treated. The @entity0 were all @entity0 with a mean age of 69 years and mean @entity3 duration of 15 years. The medical records and imaging studies of all @entity0 were reviewed. RESULTS: The affected nerve roots were L4 in four @entity0 and L3 in two @entity0 . Foraminal @entity6 was not demonstrated in magnetic resonance images in four of the six @entity0 . Selective radiculography with nerve @entity5 reproduced @entity2 , manifested blocking effect, and demonstrated compression of the nerve root by the superior articular process of the lower vertebra in all @entity0 . Conservative treatment was performed on one @entity0 , and surgery was conducted for the rest of the five @entity0 ; @entity4 was improved in all @entity0 . CONCLUSIONS: Lumbar foraminal @entity6 is a characteristic pathology of @entity3 , and should be kept in mind in the diagnosis of @entity4 . Selective radiculography is useful in the diagnosis of affected nerve roots.

title: @entity4 caused by foraminal @entity6 in XXXX .

answer: @entity3


abstract: INTRODUCTION: @entity1 or paraganglia are extremely rare and present a diagnostic dilemma. These @entity1 consist of a neuroendocrine component mixed with a neural component.We describe the imaging characteristics together with the corresponding pathological findings of a composite @entity1 . Apart from any component-specific imaging findings, the hallmark of this entity is the presence of histologically distinguishable components. CASE PRESENTATION: A 61-year-old Caucasian @entity0 was referred to our hospital due to a suspect lesion found on chest computed tomography carried out for unclear @entity3 . An abdominal computed tomography scan and ultrasound examination detected a retroperitoneal @entity1 comprising two different @entity1 components. Twenty-four-hour urine revealed high levels of @entity6 , characteristic of a @entity1 . An octreoscan prior to surgical procedures revealed @entity2 . The final histopathological workup revealed a composite @entity5 with @entity4 . Our @entity0 died ten months after the initial diagnosis from @entity1 . CONCLUSIONS: Composite @entity5 with @entity4 are rare @entity1 of the retroperitoneum. @entity1 should be considered in the differential diagnosis of retroperitoneal masses.

title: Radiological and pathological findings of a metastatic composite @entity5 with XXXX in a @entity0 : a case report.

answer: @entity4


abstract: INTRODUCTION: @entity1 or paraganglia are extremely rare and present a diagnostic dilemma. These @entity1 consist of a neuroendocrine component mixed with a neural component.We describe the imaging characteristics together with the corresponding pathological findings of a composite @entity1 . Apart from any component-specific imaging findings, the hallmark of this entity is the presence of histologically distinguishable components. CASE PRESENTATION: A 61-year-old Caucasian @entity0 was referred to our hospital due to a suspect lesion found on chest computed tomography carried out for unclear @entity3 . An abdominal computed tomography scan and ultrasound examination detected a retroperitoneal @entity1 comprising two different @entity1 components. Twenty-four-hour urine revealed high levels of @entity6 , characteristic of a @entity1 . An octreoscan prior to surgical procedures revealed @entity2 . The final histopathological workup revealed a composite @entity5 with @entity4 . Our @entity0 died ten months after the initial diagnosis from @entity1 . CONCLUSIONS: Composite @entity5 with @entity4 are rare @entity1 of the retroperitoneum. @entity1 should be considered in the differential diagnosis of retroperitoneal masses.

title: Radiological and pathological findings of a metastatic composite XXXX with @entity4 in a @entity0 : a case report.

answer: @entity5


abstract: INTRODUCTION: @entity1 or paraganglia are extremely rare and present a diagnostic dilemma. These @entity1 consist of a neuroendocrine component mixed with a neural component.We describe the imaging characteristics together with the corresponding pathological findings of a composite @entity1 . Apart from any component-specific imaging findings, the hallmark of this entity is the presence of histologically distinguishable components. CASE PRESENTATION: A 61-year-old Caucasian @entity0 was referred to our hospital due to a suspect lesion found on chest computed tomography carried out for unclear @entity3 . An abdominal computed tomography scan and ultrasound examination detected a retroperitoneal @entity1 comprising two different @entity1 components. Twenty-four-hour urine revealed high levels of @entity6 , characteristic of a @entity1 . An octreoscan prior to surgical procedures revealed @entity2 . The final histopathological workup revealed a composite @entity5 with @entity4 . Our @entity0 died ten months after the initial diagnosis from @entity1 . CONCLUSIONS: Composite @entity5 with @entity4 are rare @entity1 of the retroperitoneum. @entity1 should be considered in the differential diagnosis of retroperitoneal masses.

title: Radiological and pathological findings of a metastatic composite @entity5 with @entity4 in a XXXX : a case report.

answer: @entity0


abstract: The authors report three cases of @entity1 of the small intestine and review the literature on this subject. @entity1 of the small intestine are rare @entity0 , representing 0.2% of all @entity0 of the gastrointestinal tract. These large, round, hypervascular @entity0 are derived from smooth muscle cells in the intestinal wall and often develop extra-luminally. The malignant nature is often difficult to confirm on the histological examination. The clinical signs often only appear when the @entity0 has reached a large volume. It is rare to make the diagnosis pre-operatively, despite the use of a number of investigations. Arteriography is the most reliable examination. Spread of the disease is essentially haematogenous. The @entity0 invades adjacent organs, causes hepatic metastases and peritoneal seedlings and tends to recur locally. The treatment is essentially surgical and the prognosis varies according to the size of the @entity0 , its grade, its activity and its degree of extension. The 5-year survival of all forms of the disease varies between 20 and 50%, according to the series.

title: [ XXXX of the small intestine. Apropos of 3 cases].

answer: @entity1


abstract: BACKGROUND: To evaluate fluorescence cystoscopy with @entity7 (HAL) in the early detection of @entity4 ( @entity4 ) and @entity6 ( @entity6 ) in select high risk @entity0 . METHODS: We selected 30 consecutive @entity3 @entity0 at high risk for progression. After endoscopic resection, all @entity0 received (a) induction BCG schedule when needed, and (b) white light and fluorescence cystoscopy after 3 months. HAL at doses of 85 mg (GE Healthcare, Buckinghamshire, United Kingdom) dissolved in 50 ml of solvent to obtain an 8 mmol/L solution was instilled intravesically with a 12 Fr catheter into an empty bladder and left for 90 minutes. The solution was freshly prepared immediately before instillation. Cystoscopy was performed within 120 minutes of bladder emptying. Standard and fluorescence cystoscopy was performed using a double light system (Combilight PDD light source 5133, Wolf, Germany) which allowed an inspection under both white and blue light. RESULTS: The overall incidence was 43.3% @entity4 , 23.3% @entity6 , and 13.3% superficial transitional cell @entity1 . In 21 @entity0 , HAL cystoscopy was positive with one or more fluorescent flat lesions. Of the positive cases, there were 4 @entity6 , 10 @entity4 , 2 association of @entity6 and @entity4 , 4 well-differentiated non-infiltrating @entity3 , and 1 chronic @entity5 . In 9 @entity0 with negative HAL results, random biopsies showed 1 @entity6 and 1 @entity4 . HAL cystoscopy showed 90.1% sensitivity and 87.5% specificity with 95.2% positive predictive value and 77.8% negative predictive value. CONCLUSION: Photodynamic diagnosis should be considered a very important tool in the diagnosis of potentially evolving flat lesions on the bladder mucosa such as @entity4 and @entity6 . Moreover, detection of @entity2 that are considered precursors of @entity6 may play an important role in preventing disease progression. In our opinion, HAL cystoscopy should be recommended in the early follow-up of high risk @entity0 .

title: Early detection of urothelial premalignant lesions using hexaminolevulinate fluorescence cystoscopy in high risk XXXX .

answer: @entity0


abstract: OBJECTIVE: To investigate the expression, contribution and regulation of predominant inflammatory cytokines in the inflammation process of in a @entity0 model of keratomycosis. METHODS: It was an experimental study. Two hundred forty inbred BALB/c @entity0 were randomly divided into four groups (injury control group, @entity7 infected group, A. fumigatus infected group and @entity5 infected group) and establishment @entity2 was performed. At 1, 3, 5, and 7 days after @entity1 , the photographs of their corneas were taken using the slit lamp and the digital camera system. The presence of inflammatory cells and fungal hyphae were observed by HE and PAS staining. Four inflammatory cytokines in infectious corneas, including @entity6 , KC, @entity3 , and @entity4 , were detected respectively for expression of mRNA and protein levels, using RT-PCR and ELISA. One-way ANOVA was used to test the comparisons of the clinical scoring, RT-PCR, and ELISA, and LSD was used to test multiple comparisons. RESULTS: The course and inflammatory reaction of corneal tissue in all infected group increased at day 3 and 5 and gradually decreased after day 7 with time. The RT-PCR results showed, the mRNA expression levels of @entity6 and @entity3 were the highest in A. fumigatus infected group, and the expression levels of KC was the highest in @entity5 infected group. Additionally, the expression levels of @entity4 were found to be the highest in @entity7 infected group. The mRNA expression levels of @entity3 and KC in each experimental group were higher than those of @entity4 and @entity6 . The peak expression levels of @entity6 , KC, and @entity3 occurred at day 5, day 1, and day 3 in @entity7 infected group, A. fumigatus infected group and @entity5 infected group, respectively. However, the peak expression level of @entity4 occurred at day 1 and 7, day 1 and 7, and day 1 and 5 in the @entity7 , A. fumigatus, and @entity5 groups, respectively. The difference of mRNA expression of each cytokine had statistically significant between each groups ( @entity6 : F = 1675.339, P < 0.01; KC: F = 730.267, P < 0.01; @entity3 : F = 297.106, P < 0.01; @entity4 : F = 174.513, P < 0.01). The protein expression levels of the four cytokines in the infected groups from high to low in turn were @entity3 , @entity6 , KC and @entity4 . The trend of protein expression of the four cytokines at each time point was the same as the cytokine mRNA expression in different experimental groups as well as within the same group. The difference of protein expression of each cytokine had statistically significant between each groups ( @entity6 : F = 2871.736, P < 0.01; KC:F = 886.598, P < 0.01; @entity3 : F = 3595.488, P < 0.01; @entity4 : F = 89.225, P < 0.01). CONCLUSIONS: The expression levels of @entity6 , KC and @entity3 are closely related to the performance of the disease severity and inflammatory reaction of FK. The expression of @entity6 and @entity3 may play important role in the pathogenesis of FK.

title: [Expression of inflammatory cytokines in a XXXX model of keratomycosis].

answer: @entity0


abstract: OBJECTIVES: The risk of @entity4 after thoracic endovascular aortic repair is not widely established. The aim of this study was to assess the incidence and risk factors of @entity4 . METHODS: Between 1998 and 2008, 175 consecutive @entity0 underwent 210 procedures at 2 tertiary academic institutions. Similar nephroprotective protocols and intravascular ultrasound were used. Retrospective analysis was performed. Generalized linear model was used to identify factors associated with change in postoperative estimated glomerular filtration rate. RESULTS: Underlying @entity12 included 103 @entity7 , 72 dissections, 21 transections, and 14 penetrating @entity11 . Median preoperative estimated glomerular filtration rate was 65 mL    @entity10 m(-2). Contrast media averaged 108.7    69.8 mL. Median estimated glomerular filtration rates within 48 hours and 30 days were 69 and 67 mL    @entity10 m(-2), respectively. Rates of @entity9 risk (>25% estimated glomerular filtration rate decrease), @entity9 (>50% estimated glomerular filtration rate decrease), acute kidney function failure (>75% estimated glomerular filtration rate decrease), and hemodialysis were 9.8% (19/193), 1.6% (3/193), 0% (0/193), and 0.5% (1/193), respectively. Rates of @entity2 at 1 month and 6 months were 13.3% (10/75) and 17.7% (6/34), respectively. Risk factors for @entity9 were @entity8 , @entity3 , @entity5 , lengthy procedures, and number of stents; at 1 and 6 months they were increased age, male gender, African American race, @entity1 , chronic @entity6 , smoking, and zone 0 to 1 graft deployment. Obesity was nephroprotective. CONCLUSIONS: Thoracic aortic endograft has a significant rate of @entity2 ; however, it is lower in this cohort than in previous smaller series. Routine use of intravascular ultrasound and reduced contrast may have contributed to lower rates of @entity4 .

title: Incidence and risk factors of XXXX after thoracic endovascular aortic repair.

answer: @entity2


abstract: This report summarises the findings of a European Consensus Group review of current standards of care in locally advanced @entity4 defined as (a) untreated @entity2 extending clinically beyond the prostatic capsule in @entity0 with no evidence of lymph node invasion or distant metastases, and (b) @entity3 remaining after local treatment with positive surgical margins, @entity1 , persistent @entity5 and/or secondary @entity5 relapse. There was no overall consensus as to the standard of care in clinically apparent locally advanced @entity4 . It was agreed, however, that hormonal therapy (e.g. with a gonadotrophin releasing hormone analogue [ @entity6 ]) represents a valid treatment in these @entity0 . Treatment practices and regimens vary considerably between European countries, but @entity6 is widely used, either alone or in combination with antiandrogens. Hormonal therapy alone is a valid option, though the optimal modality, timing and duration of treatment remain to be defined. Adjuvant therapy with a @entity6 has been shown to improve survival in @entity0 undergoing external beam radiotherapy. It is a viable option after prostatectomy in @entity0 with persistent or secondary relapsing @entity5 . It was determined that optimal treatment will be different according to @entity5 , clinical staging and Gleason score, and the treatment of locally advanced disease should be individually tailored after discussion between physician and @entity0 . In many instances, @entity0 prefer and expect some form of treatment in preference to watchful waiting. Treatment nomograms such as the Kattan nomograms provide precise, comprehensive and invaluable tools for everyday use and may be used to predict outcomes and guide treatment decisions.

title: Management of locally advanced XXXX : a European consensus.

answer: @entity4


abstract: Transient @entity3 , with attendant sympathetic hyperactivity, seems to play a major role in sudden @entity1 among @entity0 with @entity3 . @entity5 ( @entity5 ) and fibrillation (VF) are consistently and repeatedly elicited in @entity2 by the interaction between a 2-minute occlusion of the left descending coronary artery and a 30-second stimulation of the left stellate ganglion. When three consecutive trials yield almost identical results, time alone will not modify the response and a given drug can be injected to test its efficacy with an internal control analysis. In 90 @entity2 the efficacy of the following drugs was assessed: @entity13 (n = 11), @entity10 (n = 12), @entity11 (n = 12), @entity6 (n = 19), @entity12 (n = 10), @entity9 (n = 14), and @entity8 (n = 12). Class I antiarrhythmic drugs completely failed to afford protection and worsening of @entity4 was observed in several instances. @entity6 and @entity12 showed efficacy in approximately 80% and 60% of the animals, respectively. @entity9 and @entity8 completely prevented the onset of @entity5 and VF. Protection from @entity4 seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation. These findings correlate with and help to explain the results of clinical trials in @entity7 @entity0 . This model may help to provide a rational choice of antiarrhythmic drugs to be tested in clinical trials.

title: The effect of antiarrhythmic drugs on life-threatening XXXX induced by the interaction between acute @entity3 and sympathetic hyperactivity.

answer: @entity4


abstract: Transient @entity3 , with attendant sympathetic hyperactivity, seems to play a major role in sudden @entity1 among @entity0 with @entity3 . @entity5 ( @entity5 ) and fibrillation (VF) are consistently and repeatedly elicited in @entity2 by the interaction between a 2-minute occlusion of the left descending coronary artery and a 30-second stimulation of the left stellate ganglion. When three consecutive trials yield almost identical results, time alone will not modify the response and a given drug can be injected to test its efficacy with an internal control analysis. In 90 @entity2 the efficacy of the following drugs was assessed: @entity13 (n = 11), @entity10 (n = 12), @entity11 (n = 12), @entity6 (n = 19), @entity12 (n = 10), @entity9 (n = 14), and @entity8 (n = 12). Class I antiarrhythmic drugs completely failed to afford protection and worsening of @entity4 was observed in several instances. @entity6 and @entity12 showed efficacy in approximately 80% and 60% of the animals, respectively. @entity9 and @entity8 completely prevented the onset of @entity5 and VF. Protection from @entity4 seems to be related to the combined presence of a noncompetitive adrenergic blockade associated with salutary effects on coronary circulation. These findings correlate with and help to explain the results of clinical trials in @entity7 @entity0 . This model may help to provide a rational choice of antiarrhythmic drugs to be tested in clinical trials.

title: The effect of antiarrhythmic drugs on life-threatening @entity4 induced by the interaction between acute XXXX and sympathetic hyperactivity.

answer: @entity3


abstract: Two hundred twenty-four @entity0 underwent ventricular programmed stimulation (VPS) without prior documentation of the clinical occurrence of sustained @entity4 ( @entity4 ) or @entity6 ( @entity6 ). Indications for VPS were: palpitations or nonsustained @entity4 during ambulatory monitoring (85 @entity0 ), @entity3 or @entity3 (137 @entity0 ), and a family history of @entity2 (two @entity0 ). @entity6 requiring transthoracic defibrillation was initiated by VPS in 18 @entity0 (8.0%). Four @entity0 were treated for inducible @entity6 with antiarrhythmic agents directed by electropharmacologic testing; five @entity0 were treated empirically; nine @entity0 received no therapy. No @entity0 has had a @entity5 or @entity2 during a follow-up period 25.2 +/- 13.8 months (mean +/- standard deviation). @entity6 was initiated by two ventricular extrastimuli in three @entity0 and by three extrastimuli in 15 @entity0 . The incidence of @entity6 was similar in @entity0 with and without previous symptoms (8.8% vs 6.9%) or @entity1 (7.1% vs 9.6%). It was significantly higher when VPS at three ventricular sites with a current of 5 mA (pulse width 2 msec) was compared to programmed stimulation at two ventricular sites with a current twice diastolic threshold (pulse width 2 msec) (15.2% vs 3.0%, p less than 0.05). @entity6 initiated by VPS in @entity0 without prior @entity4 or @entity6 appears to be a nonspecific finding. Antiarrhythmic therapy for @entity6 may not be necessary in these @entity0 .

title: Clinical significance of XXXX induced by ventricular programmed stimulation.

answer: @entity6


abstract: The safety and efficacy of oral @entity3 therapy for the suppression of @entity2 ( @entity2 ) were assessed in two clinical trials pooled for analysis. Thirty-two @entity0 suffering from @entity1 , who had experienced an average of greater than or equal to 10 @entity2 /h (range 14 to 996 three times a day) on Holter monitoring during a 24-hour baseline study period, were given @entity3 (100 mg three times a day to 400 mg four times a day) over 4 weeks. Three @entity0 were withdrawn from the study for administrative reasons, and four @entity0 were excluded from the efficacy analysis. Of the 25 remaining @entity0 (24 @entity0 , 1 @entity0 ; mean age 56 years, range 37 to 69), 18 (72%) experienced some reduction in @entity2 from the second through the fourth week of therapy. Eleven @entity0 (44%) experienced clinically significant reductions (greater than or equal to 75%) in @entity2 . The onset of the antiarrhythmic effect of @entity3 was within 7 days of administration. Transient mild to moderate side effects were noted in eight @entity0 . Significant correlations (p less than 0.001) were observed between the mean daily dose of @entity3 and (1) mean blood levels, (2) reduction in @entity2 , and (3) reduction in resting heart rate. The average daily dose of @entity3 ranged from 304 to 1060 mg. In nine @entity0 receiving @entity3 in a 12-month open-label extension, both efficacy and safety were maintained. This study confirms that oral @entity3 therapy in both safe and efficacious for suppressing @entity2 in @entity0 with @entity1 .

title: XXXX for @entity2 : short- and long-term effects.

answer: @entity3


abstract: The safety and efficacy of oral @entity3 therapy for the suppression of @entity2 ( @entity2 ) were assessed in two clinical trials pooled for analysis. Thirty-two @entity0 suffering from @entity1 , who had experienced an average of greater than or equal to 10 @entity2 /h (range 14 to 996 three times a day) on Holter monitoring during a 24-hour baseline study period, were given @entity3 (100 mg three times a day to 400 mg four times a day) over 4 weeks. Three @entity0 were withdrawn from the study for administrative reasons, and four @entity0 were excluded from the efficacy analysis. Of the 25 remaining @entity0 (24 @entity0 , 1 @entity0 ; mean age 56 years, range 37 to 69), 18 (72%) experienced some reduction in @entity2 from the second through the fourth week of therapy. Eleven @entity0 (44%) experienced clinically significant reductions (greater than or equal to 75%) in @entity2 . The onset of the antiarrhythmic effect of @entity3 was within 7 days of administration. Transient mild to moderate side effects were noted in eight @entity0 . Significant correlations (p less than 0.001) were observed between the mean daily dose of @entity3 and (1) mean blood levels, (2) reduction in @entity2 , and (3) reduction in resting heart rate. The average daily dose of @entity3 ranged from 304 to 1060 mg. In nine @entity0 receiving @entity3 in a 12-month open-label extension, both efficacy and safety were maintained. This study confirms that oral @entity3 therapy in both safe and efficacious for suppressing @entity2 in @entity0 with @entity1 .

title: @entity3 for XXXX : short- and long-term effects.

answer: @entity2


abstract: This study was conducted to determine the effects of @entity1 and body position on bilateral sternocleidomastoid electromyographic (EMG) activity. The study was performed on 20 healthy subjects with natural dentition and bilateral molar support. During @entity1 (working side), each individual had to present @entity0 guidance on one side and group function on the opposite side, without balancing-side contacts. Integrated EMG (IEMG) recordings were performed by placing bipolar surface electrodes on the right and left sternocleidomastoid muscles. IEMG activity was recorded seated upright with the head unsupported and in the right and the left lateral decubitus body positions (head, neck and body horizontally aligned), under the following experimental conditions: 1. Maximal @entity2 in the intercuspal position; 2. Laterotrusive occlusal excursion with @entity0 guidance; 3. Laterotrusive occlusal excursion with group function. Bilateral sternocleidomastoid IEMG activity with @entity0 guidance or group function was significantly lower than the intercuspal position in both body positions. In the seated upright position, significantly lower activity was observed with @entity0 guidance than in group function. In the lateral decubitus position activity was similar with both laterotrusive occlusal schemes and significantly higher than seated upright. Results suggest that both @entity1 and body position have significant influence on sternocleidomastoid IEMG activity. The clinical relevance of both factors is discussed.

title: Effects of XXXX and body position on bilateral sternocleidomastoid EMG activity.

answer: @entity1


abstract: Thirty-five couples with a variety of @entity1 problems were treated by a sperm-washing and intrauterine-insemination method. The husband's semen was washed with a modified Biggers, Whitten, and Whittingham's medium to obtain a seminal plasma-free, highly concentrated sperm suspension for intrauterine insemination. Couples receiving these inseminations were evaluated by semen analysis, zona-free hamster egg penetration test (EPT), @entity3 ( @entity3 ), @entity3 ( @entity3 ), and other appropriate @entity1 tests to determine the possible cause of @entity1 . The pregnancy rate as a group was 17%, while the spontaneous rate was found to be only 7%. @entity0 with a poor @entity3 result had a good success rate (25%) especially if the male's fertilizing ability appeared normal in the EPT (50% success). This treatment did not help @entity0 with poor EPT results or reduced sperm concentration (5% and 0% success). By excluding unsuccessful @entity0 attempting less than three months, the calculated conception rate for this treatment @entity4 %. No @entity2 or other serious complications were reported. It is concluded that this method is an uncomplicated and effective treatment for certain @entity1 @entity0 . The @entity0 most likely to be assisted by this method can be identified by using the EPT, @entity3 , and @entity3 , and these @entity0 should be treated for a minimum of three cycles.

title: Treatment of XXXX @entity0 by intrauterine insemination of washed spermatozoa.

answer: @entity1


abstract: Thirty-five couples with a variety of @entity1 problems were treated by a sperm-washing and intrauterine-insemination method. The husband's semen was washed with a modified Biggers, Whitten, and Whittingham's medium to obtain a seminal plasma-free, highly concentrated sperm suspension for intrauterine insemination. Couples receiving these inseminations were evaluated by semen analysis, zona-free hamster egg penetration test (EPT), @entity3 ( @entity3 ), @entity3 ( @entity3 ), and other appropriate @entity1 tests to determine the possible cause of @entity1 . The pregnancy rate as a group was 17%, while the spontaneous rate was found to be only 7%. @entity0 with a poor @entity3 result had a good success rate (25%) especially if the male's fertilizing ability appeared normal in the EPT (50% success). This treatment did not help @entity0 with poor EPT results or reduced sperm concentration (5% and 0% success). By excluding unsuccessful @entity0 attempting less than three months, the calculated conception rate for this treatment @entity4 %. No @entity2 or other serious complications were reported. It is concluded that this method is an uncomplicated and effective treatment for certain @entity1 @entity0 . The @entity0 most likely to be assisted by this method can be identified by using the EPT, @entity3 , and @entity3 , and these @entity0 should be treated for a minimum of three cycles.

title: Treatment of @entity1 XXXX by intrauterine insemination of washed spermatozoa.

answer: @entity0


abstract: Our experience with single stage @entity2 repair in 96 @entity0 over a 12-month period is reviewed. The ages ranged from 7 months to 14 years with an average of 3.5 years. Seventeen @entity0 were 18 months or younger at the time of operation. Meatal advancement and glanuloplasty (MAGPI) was performed in 46 @entity0 mainly with coronal and @entity2 . There was a @entity1 rate of 4%. The modified Mathieu and Mustarde operations were used for subcoronal and @entity2 . The transverse preputial island flap technique was found to be very versatile and was employed in 33 @entity0 . The @entity1 rate was 18% and proximal urethral stricture rate 9%. These complication rates are considered quite acceptable in busy centers where surgeons in training are involved in these operations. It is concluded that by mastering a relatively limited number of techniques, single stage @entity2 reconstruction can be undertaken in almost all cases at the optimal time.

title: Experience with single stage XXXX reconstruction.

answer: @entity2


abstract: The systolic and diastolic left ventricular (LV) function was studied by M-mode echocardiography in 60 @entity0 with @entity3 (mean age +/- SD, 17.1 +/- 7.5 years) and 30 healthy controls (15.4 +/- 3.8 years). In thalassemic @entity0 , echocardiograms were obtained 48 h posttransfusion, with a mean hemoglobin level of 12.4 +/- 0.9 g/dl. To examination time, thalassemic @entity0 had received 30-774 blood units (318 +/- 176). @entity2 ( @entity2 ) was present in 14 thalassemic @entity0 (19.6 +/- 3.4 years), while 46 (16.3 +/- 8.2 years) had no clinical signs of @entity2 . Global LV function study showed enlarged LV dimensions in thalassemic @entity0 with @entity2 (p less than 0.001) and similar cavity size in controls and @entity0 without @entity2 (p = NS). The same was true for velocity measurements, while diastolic LV indices had similar values in all groups (p = NS). Segmental LV function study showed no significant differences in systolic and diastolic LV posterior wall behavior between thalassemic @entity0 and controls, and even more, between thalassemic @entity0 with and without @entity2 , while it was independent of @entity1 load. These findings indicate that global and segmental LV function in thalassemic @entity0 remain within normal limits until the final stages of the disease. @entity2 onset marks the deterioration of LV systolic performance, while global and segmental diastolic indices do not change significantly. The above findings question the role of @entity1 overload in the development of @entity2 in @entity3 .

title: Global and segmental left ventricular function in XXXX .

answer: @entity3


abstract: Cerebrospinal fluid isolates of @entity2 , collected during the years 1997-2000 at more than 100 Belgian laboratories were studied. The 10 most common serotypes-serogroups representing 76% of the isolates were 14, 6, 9, 19, 23, 18, 4, 10, 8 and 12 (in order of frequency). Thirty-six percent of strains were isolated in @entity0 < 5 years old. In this age group the number of serogroups was more limited and 81.4% are included in the 7-valent conjugate vaccine. Decreased susceptibility to @entity1 was observed in 13.9% of 237 strains (MIC > 0.06 mg/L), with only 2.1% resistant strains (MIC > 1 mg/L). Twelve strains showed reduced susceptibility to @entity7 (MIC > 0.5 mg/L). Only three of the 237 strains were intermediately susceptible to meropenem. All strains were susceptible to @entity3 and @entity6 . In Belgium, high doses of third generation cephalosporins remain effective for the treatment of @entity4 . The new @entity5 seem the most promising agents for the treatment of @entity4 in the future.

title: Antibiotic susceptibility and serotype distribution of 240 XXXX causing meningitis in Belgium 1997-2000.

answer: @entity2


abstract: Immunodiffusion experiments were conducted to associate a precipitin line with @entity1 heat-labile enterotoxin (LT). Wild strains of porcine and of @entity0 enteropathogenic @entity1 as well as laboratory-derived enterotoxigenic variants of @entity3 were used for LT antigen preparations. These were produced mainly by ultrafiltration and @entity2 precipitation of broth culture supernatants. When antisera with anti-LT activity were reacted with antigen preparations from Ent(+) and Ent(-) variants of @entity3 , a line "a" was given by Ent(+) but not by Ent(-) preparations. Line "a" was removed by absorption of anti-LT serum with antigen preparation from an Ent(+) @entity3 , but was unaffected when the antigen preparation used to absorb the serum was from an Ent(-) @entity3 . A line identical to "a" was given by antigen preparations from wild strains of porcine enteropathogenic @entity1 reacted with homologous or heterologous anti-LT sera. One @entity0 of enteropathogenic @entity1 was shown to possess an antigen identical to that which gave rise to line "a." To demonstrate this line it was necessary to use high concentrations of gammaglobulin and high concentrations of the crude antigen preparations. LT preparations reacted with anticholera toxin to give a line "c," which showed a reaction of partial identity with line "b" produced by reaction of pure @entity4 and anticholera toxin. Lines "a" and "c" gave reactions of identity.

title: Immunological study of the heat-labile enterotoxins of XXXX and Vibrio cholerae.

answer: @entity1


abstract: Anatomic evidence suggests that @entity5 (Leu5-enk) may be involved in the physiologic control of @entity1 . Information regarding its pulmonary vascular effect is limited; we therefore studied its effect on the immature pulmonary circulation. Normoxic and @entity2 unsedated newborn @entity3 with chronically implanted flow probes around the right and left pulmonary arteries were used. Leu5-enk was injected into one pulmonary artery only, so that any direct effect of the peptide on the pulmonary vessels could be determined by measuring changes in the ratio of blood flow to the injected versus the non-injected lung. Leu5-enk caused a small but significant @entity0 without increasing cardiac output or left atrial pressure (threshold = 1 microgram/kg); it is therefore a pulmonary vasoconstrictor. At a dose of 10 micrograms/kg, Leu5-enk also raised pulmonary artery pressure (20.6 mmHg to 23.9 mmHg; F(8,36) = 15.1 p less than 0.001) and calculated PAR (14.6 to 16.1 units; NS). However, the ratio of blood flow to the two lungs did not change; thus, Leu5-enk does not appear to directly act on pulmonary vessels, but rather through an intermediary to produce pulmonary vasoconstriction. This indirect pulmonary vasoconstriction was blocked by pretreatment with @entity4 (3 mg/kg). We conclude that Leu5-enk is a pulmonary vasoconstrictor, albeit a weak one, in the lamb and may therefore play a role in @entity1 . This vasoconstriction does not seem to be due to a direct effect on pulmonary vessels by Leu5-enk, but may be effected through a neural or hormonal intermediary.

title: Pulmonary vascular effects of @entity5 in conscious newborn XXXX .

answer: @entity3


abstract: Anatomic evidence suggests that @entity5 (Leu5-enk) may be involved in the physiologic control of @entity1 . Information regarding its pulmonary vascular effect is limited; we therefore studied its effect on the immature pulmonary circulation. Normoxic and @entity2 unsedated newborn @entity3 with chronically implanted flow probes around the right and left pulmonary arteries were used. Leu5-enk was injected into one pulmonary artery only, so that any direct effect of the peptide on the pulmonary vessels could be determined by measuring changes in the ratio of blood flow to the injected versus the non-injected lung. Leu5-enk caused a small but significant @entity0 without increasing cardiac output or left atrial pressure (threshold = 1 microgram/kg); it is therefore a pulmonary vasoconstrictor. At a dose of 10 micrograms/kg, Leu5-enk also raised pulmonary artery pressure (20.6 mmHg to 23.9 mmHg; F(8,36) = 15.1 p less than 0.001) and calculated PAR (14.6 to 16.1 units; NS). However, the ratio of blood flow to the two lungs did not change; thus, Leu5-enk does not appear to directly act on pulmonary vessels, but rather through an intermediary to produce pulmonary vasoconstriction. This indirect pulmonary vasoconstriction was blocked by pretreatment with @entity4 (3 mg/kg). We conclude that Leu5-enk is a pulmonary vasoconstrictor, albeit a weak one, in the lamb and may therefore play a role in @entity1 . This vasoconstriction does not seem to be due to a direct effect on pulmonary vessels by Leu5-enk, but may be effected through a neural or hormonal intermediary.

title: Pulmonary vascular effects of XXXX in conscious newborn @entity3 .

answer: @entity5


abstract: This study investigated the regulation of growth hormone (GH) release in stallions and tested the hypothesis that the somatotrophic axis influences testicular function. Basal plasma GH concentrations, effects of an experimental decrease of GH release on testicular function and an opioidergic regulation of GH release were investigated in Shetland stallions (n=6). No seasonal variations in plasma GH concentrations were found over a 12-month period. Treatment with the @entity3 analogue octreotid (100mg twice daily over 10 days) caused a decrease in semen motility from 38.7+/-8.4% progressively motile spermatozoa before treatment to 18.3+/-5.4% on day 3 after end of treatment (P<0.05). Values returned to 35.0+/-8.5% on day 5 after treatment. On the last day of octreotid treatment, a hCG stimulation test was performed (3000IU hCG i.v.). The hCG-induced @entity0 release was significantly higher in saline treated than in octreotid pretreated animals (P<0.05). Neither plasma GH concentrations nor volume and density of ejaculates, total sperm count, or semen morphology were different between saline and octreotid treatments. Injection of the opioid antagonist @entity1 (0.5mg/kg) significantly increased GH release in June (from 1.1+/-0.3ng/ml before to 3.7+/-2.2), while a minor and not significant increase occurred in January. In conclusion, our results indicate a non-seasonal basal GH release with a fine-modulation by season-dependent opioidergic mechanisms in the male @entity2 . A transient decrease in semen motility and hCG-induced @entity0 release following ocreotid treatment indicate a role of GH in the regulation of testicular function in stallions.

title: XXXX treatment affects testicular function in stallions.

answer: @entity3


abstract: The objective of this paper was to present estimates on the prevalence of @entity4 of five different anatomical areas and ten anatomical sites, and their consequences and risk groups in the general Dutch population. Cross-sectional data from a population-based study of a sex-age stratified sample of Dutch inhabitants of 25 years and older were used. With a postal questionnaire data was assessed on @entity4 , additional @entity1 characteristics (location, duration, course), its consequences (utilization of health care, sick leave and limitation in daily life) and general socio-demographic characteristics. The top three of self-reported @entity4 (point prevalence (P(p)) with 95% confidence interval (CI)) was: (1). @entity2 , P(p)=26.9% (95% CI 25.5-28.3); (2). @entity1 , P(p)=20.9% (95% CI 19.6-22.2); and (3). @entity3 , P(p)=20.6% (95% CI 19.3-21.9). In most cases the @entity1 was described as continuous or recurrent and mild. In every three out of ten cases the complaints about @entity1 were accompanied by limitations in daily living. Between 33 and 42% of those with complaints consulted their general practitioner about their @entity1 . With the exception of @entity0 who are work disabled, general sociodemographic characteristics cannot be used to identify high risk groups. @entity4 is common in all subgroups of the population and has far-reaching consequences for health, work and the use of health care.

title: XXXX in the Netherlands: prevalences, consequences and risk groups, the DMC(3)-study.

answer: @entity4


abstract: The records of 46 @entity0 with @entity9 diagnosed either clinically or post-mortem were analyzed. Twenty-six @entity0 were over 60 years of age. @entity8 was the predominant organism, almost exclusively found in @entity0 with @entity6 . Thirty-six @entity0 had pre-existing @entity3 , the most common being non-rheumatic @entity5 and @entity1 . Two thirds of the @entity0 , especially those with @entity4 , developed new or progressive @entity7 . A correct clinical diagnosis was established in only 30 @entity0 . Twenty-three @entity0 died, the mortality being 71% in acute and 32% in subacute disease. Only one of eight @entity0 with @entity2 died. Four @entity0 required urgent valve replacement. Early surgical intervention should be considered in @entity0 with uncontrolled @entity7 .

title: Ten years of XXXX : a clinicopathologic study.

answer: @entity9


abstract: Eleven physically active @entity0 with systemic @entity1 were studied after 5 weeks of treatment with placebo, @entity4 or @entity3 . A double-blind, crossover randomized design was used. Blood pressure (BP), heart rate (HR), physical performance capacity, rate of perceived exertion and blood @entity2 concentrations were measured during rest, exercise to exhaustion and postexercise, at 8 and 24 hours after intake of the last dose. Blood pressure at rest and during exercise was similarly decreased with both drugs (8 and 24 hours), and there was no difference between 8 and 24 hours with any of the treatments. Heart rate (8 hours) was decreased similarly by both drugs, but after 24 hours, HR at increased workloads (above 120 watts) was higher with @entity4 compared with @entity3 . Maximal HR was lower with @entity3 than @entity4 at both 8 and 24 hours. Maximal exercise loads (8 and 24 hours) were 231 and 232 watts with placebo, 211 and 212 with @entity3 and 228 and 227 with @entity4 . That is, maximal workload was decreased with @entity3 compared with placebo and @entity4 at both 8 and 24 hours. No difference was found between placebo and @entity4 at either 8 or 24 hours. The rate of perceived exertion values were higher with @entity3 than @entity4 . Blood @entity2 concentrations did not differ according to treatments. The results indicate that @entity4 , when given in a dose that decreases resting and exercise BP to the same extent as @entity3 , limits physical performance less than @entity3 .

title: Effect of beta 1-selective and nonselective beta blockade on blood pressure relative to physical performance in @entity0 with systemic XXXX .

answer: @entity1


abstract: Eleven physically active @entity0 with systemic @entity1 were studied after 5 weeks of treatment with placebo, @entity4 or @entity3 . A double-blind, crossover randomized design was used. Blood pressure (BP), heart rate (HR), physical performance capacity, rate of perceived exertion and blood @entity2 concentrations were measured during rest, exercise to exhaustion and postexercise, at 8 and 24 hours after intake of the last dose. Blood pressure at rest and during exercise was similarly decreased with both drugs (8 and 24 hours), and there was no difference between 8 and 24 hours with any of the treatments. Heart rate (8 hours) was decreased similarly by both drugs, but after 24 hours, HR at increased workloads (above 120 watts) was higher with @entity4 compared with @entity3 . Maximal HR was lower with @entity3 than @entity4 at both 8 and 24 hours. Maximal exercise loads (8 and 24 hours) were 231 and 232 watts with placebo, 211 and 212 with @entity3 and 228 and 227 with @entity4 . That is, maximal workload was decreased with @entity3 compared with placebo and @entity4 at both 8 and 24 hours. No difference was found between placebo and @entity4 at either 8 or 24 hours. The rate of perceived exertion values were higher with @entity3 than @entity4 . Blood @entity2 concentrations did not differ according to treatments. The results indicate that @entity4 , when given in a dose that decreases resting and exercise BP to the same extent as @entity3 , limits physical performance less than @entity3 .

title: Effect of beta 1-selective and nonselective beta blockade on blood pressure relative to physical performance in XXXX with systemic @entity1 .

answer: @entity0


abstract: @entity2 occurs frequently in @entity0 with @entity3 ( @entity3 ). Although there have been case reports of detection of @entity2 by 2-dimensional echocardiography, no study has examined the frequency of @entity2 detected by cardiac ultrasound in @entity0 with @entity3 . Echocardiography was performed in 16 consecutive @entity0 with @entity3 . Physical examination revealed normal cardiac findings in each. Discrete areas of increased acoustic density were found in 8 of the 16 @entity0 (50%). The maximum diameters ranged from 3 to 20 mm. Multiple areas were found in 3 of 8. The left ventricle was involved in 5 of the 8. Six masses were intracavitary and 8 were intramyocardial. No atrial masses were seen. Left ventricular size and function were normal. Although other @entity1 cannot be excluded, the diagnosis of @entity2 is almost certain in these young @entity0 with @entity3 . The male predominance and the high incidence of intracavitary and left ventricular masses are similar to those in reported autopsy series, also supporting the diagnosis of @entity2 . The prognosis and potential for growth of these masses are not known, but can be determined by longitudinal follow-up. Cardiac ultrasound should be considered for all @entity0 with @entity3 regardless of physical findings.

title: Echocardiographic incidence of @entity2 in XXXX .

answer: @entity3