abstract: OBJECTIVE: To present upper- (UEMS) and lower-extremity motor score (LEMS) recovery, American @entity4 @entity1 ( @entity1 ) change, and motor level change in @entity0 with traumatic @entity3 from the @entity2 ( @entity2 ). DESIGN: Longitudinal cohort; follow-up to 1 year. SETTING: U.S. @entity2 . @entity0 : Subjects (N=1436; age>15y) with @entity3 with at least 2 examinations, the first within 7 days of injury. Subjects were 80% @entity0 injured by vehicular collisions (44%), falls (30%), sports (12%), and violence (11%). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Change in @entity1 , UEMS, LEMS, and motor levels. RESULTS: From a baseline of 7 days or less, 22% of subjects with @entity1 grade A converted to @entity1 grade B or better by rehabilitation discharge; and 30%, by 1 year, with 8% to @entity1 grade C and 7.1% to grade D. Conversion from complete to motor incomplete was not related to timing of the initial examination (P=.54) or initial neurologic level (P=.96). For @entity1 grade B, 34% remained motor complete, 30% became @entity1 grade C, and 37% became grade D by 1 year. Although 82.5% of those with @entity1 grade C improved to @entity1 grades D and E, mean 1-year UEMS score was only 35 points. UEMS scores in @entity0 with @entity1 grade A increased a mean of 9 to 11 points, except for C1 to C3 and C8 to T1 motor levels (gain, 2-3 points). Motor level was unchanged or ascended in 35% and improved 1 level in 42%, 2 levels in 14%, and more than 2 levels in 9%. Motor zone of partial preservation of 2 segments or more was associated with gain of 2 or more motor levels, with a relative risk of 5.0 (95% confidence interval, 3.2-7.8; P<.001). CONCLUSIONS: More @entity0 with cervical complete @entity2 may be converting to @entity1 grade D compared with earlier reports. Motor level recovery in those with @entity1 grade A and UEMS recovery in those with @entity1 grade C injuries are potential outcomes for acute clinical trials.

title: Upper- and lower-extremity motor recovery after traumatic cervical @entity2 : an update from the national XXXX database.

answer: @entity2


abstract: OBJECTIVE: To present upper- (UEMS) and lower-extremity motor score (LEMS) recovery, American @entity4 @entity1 ( @entity1 ) change, and motor level change in @entity0 with traumatic @entity3 from the @entity2 ( @entity2 ). DESIGN: Longitudinal cohort; follow-up to 1 year. SETTING: U.S. @entity2 . @entity0 : Subjects (N=1436; age>15y) with @entity3 with at least 2 examinations, the first within 7 days of injury. Subjects were 80% @entity0 injured by vehicular collisions (44%), falls (30%), sports (12%), and violence (11%). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Change in @entity1 , UEMS, LEMS, and motor levels. RESULTS: From a baseline of 7 days or less, 22% of subjects with @entity1 grade A converted to @entity1 grade B or better by rehabilitation discharge; and 30%, by 1 year, with 8% to @entity1 grade C and 7.1% to grade D. Conversion from complete to motor incomplete was not related to timing of the initial examination (P=.54) or initial neurologic level (P=.96). For @entity1 grade B, 34% remained motor complete, 30% became @entity1 grade C, and 37% became grade D by 1 year. Although 82.5% of those with @entity1 grade C improved to @entity1 grades D and E, mean 1-year UEMS score was only 35 points. UEMS scores in @entity0 with @entity1 grade A increased a mean of 9 to 11 points, except for C1 to C3 and C8 to T1 motor levels (gain, 2-3 points). Motor level was unchanged or ascended in 35% and improved 1 level in 42%, 2 levels in 14%, and more than 2 levels in 9%. Motor zone of partial preservation of 2 segments or more was associated with gain of 2 or more motor levels, with a relative risk of 5.0 (95% confidence interval, 3.2-7.8; P<.001). CONCLUSIONS: More @entity0 with cervical complete @entity2 may be converting to @entity1 grade D compared with earlier reports. Motor level recovery in those with @entity1 grade A and UEMS recovery in those with @entity1 grade C injuries are potential outcomes for acute clinical trials.

title: Upper- and lower-extremity motor recovery after traumatic cervical XXXX : an update from the national @entity2 database.

answer: @entity2


abstract: PURPOSE: Focal laser ablation is an investigational technique to treat @entity3 in a region confined manner via @entity2 . This phase I trial primarily examines the safety of transrectal magnetic resonance imaging guided (in-bore) focal laser ablation in @entity0 with intermediate @entity3 . An exploratory end point is @entity1 control after 6 months. MATERIALS AND METHODS: In an institutional review board approved trial we studied focal laser ablation in 8 @entity0 with intermediate @entity3 diagnosed using magnetic resonance-ultrasound fusion. Focal laser ablation was performed by inserting a cylindrically diffusing, water cooled laser fiber into magnetic resonance visible regions of interest, followed by interstitial heating at 10 to 15 W for up to 3 minutes. Secondary safety monitors (thermal probes) were inserted to assess the accuracy of magnetic resonance thermometry. Comprehensive magnetic resonance-ultrasound fusion biopsy was performed after 6  months. Adverse events and health related quality of life questionnaires were recorded. RESULTS: Focal laser ablation was successfully performed in all 8 subjects. No grade 3 or greater adverse events occurred and no changes in International Prostate Symptom Score or International Index of Erectile Function 5 were observed. Ablation zones, as measured by posttreatment magnetic resonance imaging, had a median volume of 3 cc or 7.7% of prostate volume. @entity4 decreased in 7 @entity0 (p <0.01). At followup magnetic resonance-ultrasound fusion biopsy @entity1 was not detected in the ablation zone in 5 @entity0 but was present outside the treatment margin in 6 @entity0 . CONCLUSIONS: Focal laser ablation of the prostate is feasible and safe in @entity0 with intermediate @entity3 , without serious adverse events or changes in urinary or sexual function at 6 months. Comprehensive biopsy followup indicates that larger treatment margins than previously thought necessary may be required for complete @entity1 ablation.

title: Focal Laser Ablation of XXXX : Phase I Clinical Trial.

answer: @entity3


abstract: UNASSIGNED: Maternal transfer of metals can be an important exposure route for animals. The maternal transfer of @entity6 and its effects on reproduction in fish are still largely unknown. In this study, @entity5 were exposed to a sublethal @entity4 concentration for 6 days (acute) and for 3 months (chronic). @entity2 accumulation in the gonads, maternal transfer of @entity6 , and effects of @entity6 on the reproduction, histopathology and expressions of antioxidants in the gonads were evaluated. Both acute and chronic exposures resulted in significant @entity6 accumulation in gonads, eggs and larvae. In chronic @entity6 -exposed fish, approximately 61% of the @entity6 accumulated in the ovary was depurated by spawning during the first 3 days after exposure, suggesting that maternal transfer is a very important pathway for accumulation in offspring. The chronic exposure caused decreases in body weight, standard length, gonad weight, gonad-somatic index (GSI) and fecundity. The last of these was most severely affected: the total number of broods and eggs per female decreased by 57.1% and 75.9%, respectively. Moreover, egg weight and fertilization rate were also reduced (by approximately 20%) following chronic @entity4 exposure. Histopathological analyses showed that the @entity6 exposure resulted in the onset of follicular @entity1 and a reduction in the number of mature oocytes, along with a reduction in abundance of mature spermatozoa in testes. The @entity3 / @entity7 ratio was greatly elevated after chronic @entity4 exposure, implying that @entity3 played a role in scavenging the reactive @entity0 species generated by the reduction of @entity4 inside cells. This study provides evidence for the maternal transfer of @entity6 , highlights the importance of spawning in @entity6 depuration from the ovary, and demonstrates that chronic @entity4 exposure has serious impacts on reproduction in the @entity5 . Our results suggest that the issue of chronic @entity6 pollution deserves more attention than it has received to date.

title: Maternal transfer and reproductive effects of @entity4 in XXXX ( @entity5 ) under acute and chronic exposures.

answer: @entity5


abstract: UNASSIGNED: Maternal transfer of metals can be an important exposure route for animals. The maternal transfer of @entity6 and its effects on reproduction in fish are still largely unknown. In this study, @entity5 were exposed to a sublethal @entity4 concentration for 6 days (acute) and for 3 months (chronic). @entity2 accumulation in the gonads, maternal transfer of @entity6 , and effects of @entity6 on the reproduction, histopathology and expressions of antioxidants in the gonads were evaluated. Both acute and chronic exposures resulted in significant @entity6 accumulation in gonads, eggs and larvae. In chronic @entity6 -exposed fish, approximately 61% of the @entity6 accumulated in the ovary was depurated by spawning during the first 3 days after exposure, suggesting that maternal transfer is a very important pathway for accumulation in offspring. The chronic exposure caused decreases in body weight, standard length, gonad weight, gonad-somatic index (GSI) and fecundity. The last of these was most severely affected: the total number of broods and eggs per female decreased by 57.1% and 75.9%, respectively. Moreover, egg weight and fertilization rate were also reduced (by approximately 20%) following chronic @entity4 exposure. Histopathological analyses showed that the @entity6 exposure resulted in the onset of follicular @entity1 and a reduction in the number of mature oocytes, along with a reduction in abundance of mature spermatozoa in testes. The @entity3 / @entity7 ratio was greatly elevated after chronic @entity4 exposure, implying that @entity3 played a role in scavenging the reactive @entity0 species generated by the reduction of @entity4 inside cells. This study provides evidence for the maternal transfer of @entity6 , highlights the importance of spawning in @entity6 depuration from the ovary, and demonstrates that chronic @entity4 exposure has serious impacts on reproduction in the @entity5 . Our results suggest that the issue of chronic @entity6 pollution deserves more attention than it has received to date.

title: Maternal transfer and reproductive effects of @entity4 in @entity5 ( XXXX ) under acute and chronic exposures.

answer: @entity5


abstract: UNASSIGNED: Maternal transfer of metals can be an important exposure route for animals. The maternal transfer of @entity6 and its effects on reproduction in fish are still largely unknown. In this study, @entity5 were exposed to a sublethal @entity4 concentration for 6 days (acute) and for 3 months (chronic). @entity2 accumulation in the gonads, maternal transfer of @entity6 , and effects of @entity6 on the reproduction, histopathology and expressions of antioxidants in the gonads were evaluated. Both acute and chronic exposures resulted in significant @entity6 accumulation in gonads, eggs and larvae. In chronic @entity6 -exposed fish, approximately 61% of the @entity6 accumulated in the ovary was depurated by spawning during the first 3 days after exposure, suggesting that maternal transfer is a very important pathway for accumulation in offspring. The chronic exposure caused decreases in body weight, standard length, gonad weight, gonad-somatic index (GSI) and fecundity. The last of these was most severely affected: the total number of broods and eggs per female decreased by 57.1% and 75.9%, respectively. Moreover, egg weight and fertilization rate were also reduced (by approximately 20%) following chronic @entity4 exposure. Histopathological analyses showed that the @entity6 exposure resulted in the onset of follicular @entity1 and a reduction in the number of mature oocytes, along with a reduction in abundance of mature spermatozoa in testes. The @entity3 / @entity7 ratio was greatly elevated after chronic @entity4 exposure, implying that @entity3 played a role in scavenging the reactive @entity0 species generated by the reduction of @entity4 inside cells. This study provides evidence for the maternal transfer of @entity6 , highlights the importance of spawning in @entity6 depuration from the ovary, and demonstrates that chronic @entity4 exposure has serious impacts on reproduction in the @entity5 . Our results suggest that the issue of chronic @entity6 pollution deserves more attention than it has received to date.

title: Maternal transfer and reproductive effects of XXXX in @entity5 ( @entity5 ) under acute and chronic exposures.

answer: @entity4


abstract: BACKGROUND: Treatment of @entity0 with @entity4 has trended toward longer duration despite the absence of supporting clinical trials. OBJECTIVE: To evaluate different durations of oral @entity5 treatment and the combination of oral @entity5 and a single intravenous dose of @entity3 for treatment of @entity0 with @entity4 . DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Single-center university hospital. @entity0 : 180 @entity0 with @entity6 . INTERVENTION: Ten days of oral @entity5 , with or without a single intravenous dose of @entity3 , or 20 days of oral @entity5 . MEASUREMENTS: Outcome was based on clinical observations and neurocognitive testing. Efficacy was assessed at 20 days, 3 months, 12 months, and 30 months. RESULTS: At all time points, the complete response rate was similar for the three treatment groups in both on-study and intention-to-treat analyses. In the on-study analysis, the complete response rate at 30 months was 83.9% in the 20-day @entity5 group, 90.3% in the 10-day @entity5 group, and 86.5% in the @entity5 - @entity3 group (P > 0.2). The only @entity0 with treatment failure (10-day @entity5 group) developed @entity2 on day 18. There were no significant differences in the results of neurocognitive testing among the three treatment groups and a separate control group without @entity4 . @entity1 occurred significantly more often in the @entity5 - @entity3 group (35%) than in either of the other two groups (P < 0.001). CONCLUSIONS: Extending treatment with @entity5 from 10 to 20 days or adding one dose of @entity3 to the beginning of a 10-day course of @entity5 did not enhance therapeutic efficacy in @entity0 with @entity6 . Regardless of regimen, objective evidence of treatment failure was extremely rare.

title: Duration of antibiotic therapy for XXXX . A randomized, double-blind, placebo-controlled trial.

answer: @entity4


abstract: Thirty-one @entity0 with @entity3 underwent total cystectomy between April, 1969 and March, 1984. The overall five-year survival rate was 62.2%, and the ten-year survival rate was 55.0%. However, 11 of the 12 @entity2 deaths occurred within 5 years. The survival rate was significantly higher in G1 than in G2 or G3, but there was no significant difference between G2 and G3. The survival rate was clearly different between the superficial and deep invasive type. The group of stage pT1a or less had a significantly higher survival rate than the group of pT1b. No significant difference was detected among the groups of stage pT1b or higher. The presence of intramural lymphatic invasion (ly) may be an important prognostic factor. Pelvic lymph node @entity1 was detected in 28.6% of ly 1, and in 71.4% of ly 2. The @entity3 could be rationally classified into a superficial type and an invasive type according to the destruction of the lamina proprie. Proper adjuvant therapy should be performed for the invasive type which shows ly-positive @entity2 .

title: [Clinical evaluation of total cystectomy in @entity0 with XXXX ].

answer: @entity3


abstract: Thirty-one @entity0 with @entity3 underwent total cystectomy between April, 1969 and March, 1984. The overall five-year survival rate was 62.2%, and the ten-year survival rate was 55.0%. However, 11 of the 12 @entity2 deaths occurred within 5 years. The survival rate was significantly higher in G1 than in G2 or G3, but there was no significant difference between G2 and G3. The survival rate was clearly different between the superficial and deep invasive type. The group of stage pT1a or less had a significantly higher survival rate than the group of pT1b. No significant difference was detected among the groups of stage pT1b or higher. The presence of intramural lymphatic invasion (ly) may be an important prognostic factor. Pelvic lymph node @entity1 was detected in 28.6% of ly 1, and in 71.4% of ly 2. The @entity3 could be rationally classified into a superficial type and an invasive type according to the destruction of the lamina proprie. Proper adjuvant therapy should be performed for the invasive type which shows ly-positive @entity2 .

title: [Clinical evaluation of total cystectomy in XXXX with @entity3 ].

answer: @entity0


abstract: The Lee @entity2 ( @entity2 ) Symptom Scale has been recommended for use by the 2005 and 2014 National Institutes of Health (NIH) Consensus Conferences to capture @entity2 symptoms. Although the @entity2 Symptom Scale was previously validated, this study aims to reexamine the instrument's content validity by exploring the clarity, comprehensibility, relevance, and ease of use in a contemporary @entity2 sample, toward Food and Drug Administration (FDA) qualification of this @entity0 -reported outcomes (PRO) instrument as a drug development tool. Attaining FDA qualification means that an instrument has been judged to be a reliable and valid measure of clinical benefit. Twenty adult @entity0 with a median age of 58  year (range, 31 to 79  years) participated. The median duration of @entity2 was 33  months (range, 0 to 134.4  months), and current NIH severity score was mild in 1 @entity0 , moderate in 10 @entity0 , and severe in 9 @entity0 , with a median of 5.5 treatments (range, 0 to 14) ever used for @entity2 . The median summary score was 23 (range, 8 to 51), and the median time to complete the scale was 2  minutes, 7  seconds (range, 1  minute, 8  seconds to 4  minutes). Symptoms of @entity2 were well captured on the Lee @entity2 Symptom Scale, although 4 additional symptoms/signs were mentioned by 15% of the @entity0 . @entity0 mostly reported that item wording was clear and provided accurate definitions of specific terminologies; however, 7 @entity0 (35%) reported finding 1 or more items in the skin domain unclear, reporting, for example, that rashes and itchy skin seemed synonymous. Two of 19 @entity0 (10.5%) described how their answers would have changed had they been asked about their symptoms within the past month instead of within the past week, owing to recently resolved symptoms. All @entity0 were able to accurately explain the concept of "bother" in their own words and distinguish it from symptom severity or other related symptom attributes. In summary, @entity0 found the Lee GVHD Symptom Scale to be a comprehensive and understandable way to report their @entity2 symptom experience. Future work will focus on options for the recall period, the phrasing of skin items, and whether some very rare symptoms (eg, feeding tube, use of @entity1 ) should continue to be a part of the scale.

title: Content Validity of the Lee XXXX Symptom Scale as Assessed by Cognitive Interviews.

answer: @entity2


abstract: BACKGROUND: There have been no studies of atrial diastolic function after catheter ablation of @entity10 ( @entity10 ). We encountered a few @entity0 with symptomatic left @entity11 and associated @entity4 ( @entity4 ) that developed after catheter ablation for @entity10 . Similar findings were described in @entity0 after cardiac surgery and were referred to as the "stiff @entity13 ." OBJECTIVE: The purpose of this study was to prospectively quantify the incidence of @entity0 developing @entity4 associated with diastolic hemodynamic abnormalities of the LA after radiofrequency ablation of @entity10 and to identify the possible predictors. METHODS: Between January 2009 and July 2010, data on 1,380 consecutive @entity0 were prospectively collected. Before ablation and at follow-up, all @entity0 had an echocardiogram to assess for the presence of @entity4 . @entity0 with no echocardiographic evidence of @entity4 but complaining of unexplained @entity12 with @entity13 were evaluated with @entity5 ( @entity5 ). @entity0 were included in the analysis if they developed new or worsening @entity4 postablation with evidence of LA @entity3 by @entity5 or direct LA pressure measurement. All @entity0 were evaluated for @entity8 and excluded if this condition was identified. RESULTS: The mean age was 62    11 (75% male), and nonparoxysmal @entity10 was the predominant @entity9 (71%). New or worsening @entity4 with associated @entity13 was detected in 19 (1.4%) @entity0 after ablation. The prevalence of @entity4 did not differ between @entity10 types (P = .612). Compared with @entity0 who did not develop @entity4 , LA scarring (P <.001), @entity1 (P = .026), and @entity2 ( @entity2 ; P = .006) were more frequently observed among those who developed @entity4 . In a multivariable logistic model, preprocedure LA size  <=45 mm (odds ratio [OR] = 6.13; P = .033), mean LA pressure (OR 1.14; P = .025), severe LA scarring (OR = 4.4; P = .046), @entity1 (OR = 9.5; P = .004), and @entity2 (OR = 6.2; P = .009) were independently associated with the development of @entity4 postablation. CONCLUSIONS: After radiofrequency catheter ablation of @entity10 (RFCAF), @entity4 with LA @entity3 or the so-called stiff LA syndrome is a rare but potentially significant complication of @entity10 ablation. Severe LA scarring, LA  <=45 mm, @entity1 , @entity2 , and high LA pressure are clinical variables that predict the development of this syndrome. The main clinical findings include @entity12 , @entity7 , @entity4 , and large V waves on pulmonary capillary wedge pressure (PCWP) or LA pressure tracings in the absence of @entity6 .

title: Stiff @entity13 after catheter ablation for XXXX : clinical characterization, prevalence, and predictors.

answer: @entity10


abstract: BACKGROUND: There have been no studies of atrial diastolic function after catheter ablation of @entity10 ( @entity10 ). We encountered a few @entity0 with symptomatic left @entity11 and associated @entity4 ( @entity4 ) that developed after catheter ablation for @entity10 . Similar findings were described in @entity0 after cardiac surgery and were referred to as the "stiff @entity13 ." OBJECTIVE: The purpose of this study was to prospectively quantify the incidence of @entity0 developing @entity4 associated with diastolic hemodynamic abnormalities of the LA after radiofrequency ablation of @entity10 and to identify the possible predictors. METHODS: Between January 2009 and July 2010, data on 1,380 consecutive @entity0 were prospectively collected. Before ablation and at follow-up, all @entity0 had an echocardiogram to assess for the presence of @entity4 . @entity0 with no echocardiographic evidence of @entity4 but complaining of unexplained @entity12 with @entity13 were evaluated with @entity5 ( @entity5 ). @entity0 were included in the analysis if they developed new or worsening @entity4 postablation with evidence of LA @entity3 by @entity5 or direct LA pressure measurement. All @entity0 were evaluated for @entity8 and excluded if this condition was identified. RESULTS: The mean age was 62    11 (75% male), and nonparoxysmal @entity10 was the predominant @entity9 (71%). New or worsening @entity4 with associated @entity13 was detected in 19 (1.4%) @entity0 after ablation. The prevalence of @entity4 did not differ between @entity10 types (P = .612). Compared with @entity0 who did not develop @entity4 , LA scarring (P <.001), @entity1 (P = .026), and @entity2 ( @entity2 ; P = .006) were more frequently observed among those who developed @entity4 . In a multivariable logistic model, preprocedure LA size  <=45 mm (odds ratio [OR] = 6.13; P = .033), mean LA pressure (OR 1.14; P = .025), severe LA scarring (OR = 4.4; P = .046), @entity1 (OR = 9.5; P = .004), and @entity2 (OR = 6.2; P = .009) were independently associated with the development of @entity4 postablation. CONCLUSIONS: After radiofrequency catheter ablation of @entity10 (RFCAF), @entity4 with LA @entity3 or the so-called stiff LA syndrome is a rare but potentially significant complication of @entity10 ablation. Severe LA scarring, LA  <=45 mm, @entity1 , @entity2 , and high LA pressure are clinical variables that predict the development of this syndrome. The main clinical findings include @entity12 , @entity7 , @entity4 , and large V waves on pulmonary capillary wedge pressure (PCWP) or LA pressure tracings in the absence of @entity6 .

title: Stiff XXXX after catheter ablation for @entity10 : clinical characterization, prevalence, and predictors.

answer: @entity13


abstract: @entity3 and diastolic function was assessed in 12 @entity0 after total correction of tetralogy of Fallot (age range 5 to 18 years, mean 10) and compared with 10 control @entity0 . Only 1 @entity0 had a shunt before total correction that was performed at a mean age of 3.5 years, (range 0.3 to 8). At cardiac catheterization the following indexed LV parameters were measured: end-diastolic and end-systolic volumes, wall mass, ejection fraction, @entity1 volume and end-diastolic and end-systolic pressures and stresses. The rate-corrected mean velocity of fiber shortening was calculated. LV diastolic operant chamber stiffness and @entity2 were calculated from simultaneous diastolic pressures and volumes in mid- and late diastole using monoexponential formulas. The 2 groups were compared by unpaired t tests. The tetralogy group had higher mean end-diastolic (93 vs 74 ml/m2), end-systolic (29 vs 19 ml/m2) and @entity1 (64 vs 55 ml/m2) volumes than controls. Rate-corrected mean velocity of fiber shortening was lower in the tetralogy group (1.07 vs 1.24). @entity2 was higher in the tetralogy group (16 vs 11). Other indexes were not significantly different. Thus, LV function after total correction of tetralogy of Fallot may be abnormal with larger than normal LV size, decreased contractile function and increased @entity2 .

title: XXXX and diastolic function after total correction of tetralogy of Fallot.

answer: @entity3


abstract: BACKGROUND: The purpose of this study was to identify prognostic factors related to recurrence in @entity1 treated with breast-conserving surgery (BCS) and to predict the recurrence following breast-conserving therapy (BCT) by constructing a prediction model. METHODS: The retrospective analysis included 764 consecutive @entity0 @entity1 treated with BCT in Shanghai @entity2 Center between 1995 and 2008. Univariate and multivariate analysis were performed to identify independent risk factors for locoregional recurrence (LRR) and all the recurrence events. Logistic regression was used to construct a recurrence prediction model, which was further evaluated by receiver operating characteristics (ROC) curves. RESULTS: The 5-year locoregional @entity3 (LRRFS) and @entity3 ( @entity3 ) rates were 90.8 and 88.4%, respectively. Multivariate analysis revealed 1 independent predictive factor for LRRFS (lymph node, P  =  .0049) and three independent predictive factors for @entity3 (lymph node, P  =  .0036; molecular subtype, P  =  .0021; histological grade, P  =  .041). These three variables entered into logistic regression to establish a recurrent prediction model. ROC curve showed that the area under the curve (AUC) of the established model was 0.70 (95% confidence interval: 0.61-0.78). This model could classify @entity1 into "high-risk recurrence" and "low-risk recurrence" groups and could successfully predict their prognosis (P  <  .00001). CONCLUSIONS: The information of lymph node status, molecular subtype, and grade may help doctors to evaluate recurrence risk of a @entity1 treated with BCT. Our new model might be helpful in clinical practice for recurrence prediction after BCT in Chinese @entity1 , though further validation studies are needed.

title: Predicting XXXX recurrence following breast-conserving therapy: a single-institution analysis consisting of 764 Chinese @entity0 cases.

answer: @entity0


abstract: BACKGROUND: The purpose of this study was to identify prognostic factors related to recurrence in @entity1 treated with breast-conserving surgery (BCS) and to predict the recurrence following breast-conserving therapy (BCT) by constructing a prediction model. METHODS: The retrospective analysis included 764 consecutive @entity0 @entity1 treated with BCT in Shanghai @entity2 Center between 1995 and 2008. Univariate and multivariate analysis were performed to identify independent risk factors for locoregional recurrence (LRR) and all the recurrence events. Logistic regression was used to construct a recurrence prediction model, which was further evaluated by receiver operating characteristics (ROC) curves. RESULTS: The 5-year locoregional @entity3 (LRRFS) and @entity3 ( @entity3 ) rates were 90.8 and 88.4%, respectively. Multivariate analysis revealed 1 independent predictive factor for LRRFS (lymph node, P  =  .0049) and three independent predictive factors for @entity3 (lymph node, P  =  .0036; molecular subtype, P  =  .0021; histological grade, P  =  .041). These three variables entered into logistic regression to establish a recurrent prediction model. ROC curve showed that the area under the curve (AUC) of the established model was 0.70 (95% confidence interval: 0.61-0.78). This model could classify @entity1 into "high-risk recurrence" and "low-risk recurrence" groups and could successfully predict their prognosis (P  <  .00001). CONCLUSIONS: The information of lymph node status, molecular subtype, and grade may help doctors to evaluate recurrence risk of a @entity1 treated with BCT. Our new model might be helpful in clinical practice for recurrence prediction after BCT in Chinese @entity1 , though further validation studies are needed.

title: Predicting @entity0 recurrence following breast-conserving therapy: a single-institution analysis consisting of 764 Chinese XXXX cases.

answer: @entity0


abstract: BACKGROUND: Increased @entity1 expression of @entity4 ( @entity4 ) is associated with decreased survival in @entity0 with @entity1 . Its effect in @entity2 ( @entity2 ) is not defined. METHODS: Ninety-five @entity0 were selected from a prospective database of all @entity0 (n  =  220) who underwent pancreaticoduodenectomy for @entity2 between January 2000 and October 2008. @entity1 was isolated to perform immunohistochemistry for @entity4 expression and was graded by a single pathologist. Main outcomes were @entity3 ( @entity3 ) and @entity3 ( @entity3 ). RESULTS: Median age was 63  years; 50 @entity0 (53%) were male and 73 (77%) received adjuvant chemotherapy. Median follow-up was 25  months. Median @entity3 and @entity3 was 9 and 16  months. Median @entity1 size was 3  cm; 26% had a positive resection margin, 34% had poorly differentiated @entity1 , 61% had positive lymph nodes, 88% had perineural invasion, and 45% had lymphovascular invasion. @entity1 exhibited differential @entity4 expression in terms of intensity staining [none-weak: 61%; moderate-strong: 39%], percentage staining [0: 39%; 1-10: 29%; 11-50: 20%; 51-100: 12%], and overall expression [low: 84%; high: 16%]. High @entity4 expression was associated with reduced @entity3 (6 vs. 10  months; P  =  0.03) and decreased @entity3 (9 vs. 18  months; P  =  0.019). After accounting for @entity1 factors, high @entity4 expression persisted as a negative prognostic factor on multivariate Cox regression for both @entity3 and @entity3 [hazards ratio (HR), 2.1; 95% confidence interval (CI), 1.1-3.9; P  =  0.02; HR, 3; 95% CI, 1.6-6; P  =  0.001, respectively]. A subset analysis of only those 73 @entity0 who received adjuvant therapy revealed the same negative effect of high @entity4 expression on @entity3 (4 vs. 15  months; P  =  0.001) and @entity3 (9 vs. 20  months; P  <  0.001). CONCLUSIONS: @entity2 exhibits differential expression of @entity4 . High @entity4 expression is associated with both reduced @entity3 and @entity3 after resection. @entity4 expression levels may help to predict @entity0 outcome with adjuvant chemotherapy.

title: Differential expression of XXXX in pancreas adenocarcinoma: high @entity1 expression is associated with earlier recurrence and shortened survival after resection.

answer: @entity4


abstract: BACKGROUND: Increased @entity1 expression of @entity4 ( @entity4 ) is associated with decreased survival in @entity0 with @entity1 . Its effect in @entity2 ( @entity2 ) is not defined. METHODS: Ninety-five @entity0 were selected from a prospective database of all @entity0 (n  =  220) who underwent pancreaticoduodenectomy for @entity2 between January 2000 and October 2008. @entity1 was isolated to perform immunohistochemistry for @entity4 expression and was graded by a single pathologist. Main outcomes were @entity3 ( @entity3 ) and @entity3 ( @entity3 ). RESULTS: Median age was 63  years; 50 @entity0 (53%) were male and 73 (77%) received adjuvant chemotherapy. Median follow-up was 25  months. Median @entity3 and @entity3 was 9 and 16  months. Median @entity1 size was 3  cm; 26% had a positive resection margin, 34% had poorly differentiated @entity1 , 61% had positive lymph nodes, 88% had perineural invasion, and 45% had lymphovascular invasion. @entity1 exhibited differential @entity4 expression in terms of intensity staining [none-weak: 61%; moderate-strong: 39%], percentage staining [0: 39%; 1-10: 29%; 11-50: 20%; 51-100: 12%], and overall expression [low: 84%; high: 16%]. High @entity4 expression was associated with reduced @entity3 (6 vs. 10  months; P  =  0.03) and decreased @entity3 (9 vs. 18  months; P  =  0.019). After accounting for @entity1 factors, high @entity4 expression persisted as a negative prognostic factor on multivariate Cox regression for both @entity3 and @entity3 [hazards ratio (HR), 2.1; 95% confidence interval (CI), 1.1-3.9; P  =  0.02; HR, 3; 95% CI, 1.6-6; P  =  0.001, respectively]. A subset analysis of only those 73 @entity0 who received adjuvant therapy revealed the same negative effect of high @entity4 expression on @entity3 (4 vs. 15  months; P  =  0.001) and @entity3 (9 vs. 20  months; P  <  0.001). CONCLUSIONS: @entity2 exhibits differential expression of @entity4 . High @entity4 expression is associated with both reduced @entity3 and @entity3 after resection. @entity4 expression levels may help to predict @entity0 outcome with adjuvant chemotherapy.

title: Differential expression of @entity4 in pancreas adenocarcinoma: high XXXX expression is associated with earlier recurrence and shortened survival after resection.

answer: @entity1


abstract: Many bacteriophages, such as @entity1 , T7, RB49, and phi29, have complex, sometimes multilayered, tails that facilitate an almost 100% success rate for the viral particles to infect host cells. In @entity1 , there is a baseplate, which is a multiprotein assembly, at the distal end of the contractile tail. The baseplate communicates to the tail that the phage fibers have attached to the host cell, thereby initiating the infection process. Gene product 8 (gp8), whose @entity0 sequence consists of 334 residues, is one of at least 16 different structural proteins that constitute the @entity1 baseplate and is the sixth baseplate protein whose structure has been determined. A 2.0A resolution X-ray structure of gp8 shows that the two-domain protein forms a dimer, in which each monomer consists of a three-layered beta-sandwich with two loops, each containing an alpha-helix at the opposite sides of the sandwich. The crystals of gp8 were produced in the presence of concentrated @entity2 and @entity4 ions, resulting in at least 11 @entity3 -binding sites per monomer. Five @entity3 sites, situated at the N termini of alpha-helices, have a protein environment observed in other @entity3 -containing protein crystal structures. The computer programs EMfit and SITUS were used to determine the positions of six gp8 dimers within the 12A resolution cryo-electron microscopy image reconstruction of the baseplate-tail tube complex. The gp8 dimers were found to be located in the upper part of the baseplate outer rim. About 20% of the gp8 surface is involved in contacts with other baseplate proteins, presumed to be gp6, @entity5 , and gp10. With the structure determination of gp8, a total of 53% of the volume of the baseplate has now been interpreted in terms of its atomic structure.

title: Structure and location of gene product 8 in the XXXX baseplate.

answer: @entity1


abstract: UNASSIGNED: @entity4 long-term nonprogressors (LTNPs) maintaining high @entity3 (+) T-cell counts without antiretroviral therapy (ART) are divided into elite controllers (ECs) with undetectable and viremic controllers (VCs) with low viral loads. Little is known about the long-term changes of T-cell subsets and @entity0 patterns in ECs versus VCs. The aim of the study was to explore the long-term evolution of @entity3 (+) T-cell levels in LTNPs and to analyze cytokine profiles in ECs versus VCs. Nineteen ECs and 15 VCs were enrolled from the natural virus controller cohort (NaViC). T-cell counts were monitored over years, the mean annual change was calculated, and plasma concentrations of 25 cytokines were evaluated using a multiplex bead array. While absolute numbers of T cells did not differ between ECs and VCs over time, we observed a significant decrease of @entity3 (+) T-cell percentages in VCs, but not in ECs (median [interquartile range]: ECs: 37% [28-41] vs. VCs: 29% [25-34]; p   =   .02). ECs had lower levels of @entity5 ( @entity5 , p   =   .003), interferon @entity1 ( @entity1 , p   =   .03), and monokine induced by interferon-y ( @entity2 , p   =   .02). @entity3 (+) T-cell percentages inversely correlated with @entity5 (r   =   -0.42, p   =   .017) and @entity1 (r   =   -0.77, p   <   .0001). A subtle decline of @entity3 (+) T-cell percentages could be observed in VCs, but not in ECs, which was associated with higher plasma levels of proinflammatory cytokines. Hence, even low levels of @entity4 replication might go along with a progressive decline in @entity3 (+) T-cell counts in LTNPs.

title: Cytokine and Chemokine Signature in Elite Versus Viremic Controllers Infected with XXXX .

answer: @entity4


abstract: BACKGROUND AND STUDY AIMS: The role of urgent endoscopy in high-risk nonvariceal @entity1 (NVUGIB) is unclear. The aim of this study was to determine whether esophagogastroduodenoscopy (EGD) performed sooner than the currently recommended 24 h in high-risk @entity0 presenting with NVUGIB is associated with lower all-cause in-hospital mortality. METHODS: All adult @entity0 undergoing EGD for the indications of coffee-grounds vomitus, hematemesis or melena at a university hospital over an 18-month period were enrolled. @entity0 with variceal and lower @entity1 were excluded. Data were prospectively collected. RESULTS: A total of 934 @entity0 were included. The area under the receiver operating characteristic curve (AUROC) for the @entity2 ( @entity2 ) was 0.813 for predicting all-cause in-hospital mortality, with a cut-off score of >=  12 resulting in 90 % specificity. In low-risk @entity0 with @entity2 < 12, presentation-to-endoscopy time in those who died and in those who survived was similar. In high-risk @entity0 with @entity2 of >=  12, presentation-to-endoscopy time was significantly longer in those who died than in those who survived. Multivariate analysis of the high-risk cohort showed presentation-to-endoscopy time to be the only factor associated with all-cause in-hospital mortality. For high-risk @entity0 , the AUROC for presentation-to-endoscopy time in predicting all-cause in-hospital mortality was 0.803, with a sensitivity of 100 % at the cut-off time of 13 h. All-cause in-hospital mortality in high-risk @entity0 was significantly higher in those with presentation-to-endoscopy time of > 13 h compared with those undergoing endoscopy in < 13 h from presentation (44 % vs. 0 %; P < 0.001). CONCLUSIONS: Endoscopy within 13 h of presentation was associated with lower mortality in high-risk but not low-risk NVUGIB.

title: Urgent endoscopy is associated with lower mortality in high-risk but not low-risk nonvariceal XXXX .

answer: @entity1


abstract: CONTEXT AND OBJECTIVE: There has been increased attention to the issue of fertility preservation (FP). We aimed to investigate the long-term safety of FP via controlled ovarian stimulation with letrozole supplementation (COSTLES) prior to @entity0 treatment. DESIGN, SETTING AND @entity1 : This is a prospective non-randomized controlled study conducted between the years 2002 and 2014. A total of 337 @entity1 diagnosed with stage  <=3 invasive @entity0 were enrolled during a FP consultation before chemotherapy. Of those, 120 elected to undergo COSTLES for FP prior to chemotherapy (FP group). The remaining 217 @entity1 did not undergo any FP procedure and served as controls. MAIN OUTCOME MEASURE: Primary endpoint was @entity2 recurrence defined as the detection of @entity2 (chest wall, regional nodal disease), distant metastases, or contralateral invasive @entity0 . RESULTS: The baseline characteristics at enrollment were similar between FP and control groups except for the less frequent lymph node involvement (P = 0.02) in the former. The mean follow-up after diagnosis was 5.0 years in the FP and 6.9 years in the control group. In the FP group, the hazard ratio for recurrence after ovarian stimulation was 0.77 (95% CI: 0.28, 2.13) and the survival was not compromised compared with controls (P = 0.61). Neither @entity4 gene mutation status (P = 0.57), nor undergoing FP before or after breast surgery (P = 0.44) affected survival outcomes in FP group. Likewise, none of the @entity2 characteristics including the @entity3 receptor status affected the survival rates following COSTLES. CONCLUSION: COSTLES is unlikely to cause substantially increased recurrence risk in @entity0 during the 5 years after diagnosis.

title: LONG-TERM SAFETY OF LETROZONE AND GONADOTROPIN STIMULATION FOR FERTILITY PRESERVATION IN XXXX WITH BREAST CANCER.

answer: @entity1


abstract: Hypofrontality and decreased lateralization have been two major, albeit controversial, results from functional neuroimaging studies of @entity2 . We used fMRI to study cortical activation during a @entity4 (WM) task (2-back) in 15 inpatients acutely ill with @entity2 and 15 matched control subjects. We hypothesized (i) hypofrontality in @entity0 in both tasks and (ii) decreased lateralization of prefrontal activation in @entity0 under the assumption that, in controls, left prefrontal cortex (PFC) is engaged preferentially in the verbal task (verbal domain dominance) and the right prefrontal cortex is engaged preferentially in the spatial task (spatial domain dominance). Our results showed no significant differences in frontal activation between controls and @entity0 , i.e. no hypofrontality in @entity0 , even at a very liberal threshold (p<0.01). This may be explained by the fact that nearly all @entity0 studied received atypical neuroleptics. Nonetheless, we found evidence for more subtle, domain-related @entity3 . Whereas controls showed verbal WM domain dominance in @entity1 and spatial WM domain dominance in right prefrontal cortex, these domain dominance effects were absent in the @entity0 group, i.e. there were no lateralization effects. Finally, only @entity0 showed an inverse correlation between performance and right prefrontal activation in verbal WM. We conclude that the finding of hypofrontality may depend on the medication of the @entity0 and that there is @entity3 even in the absence of hypofrontality.

title: No hypofrontality, but absence of prefrontal lateralization comparing XXXX in @entity2 .

answer: @entity4


abstract: Hypofrontality and decreased lateralization have been two major, albeit controversial, results from functional neuroimaging studies of @entity2 . We used fMRI to study cortical activation during a @entity4 (WM) task (2-back) in 15 inpatients acutely ill with @entity2 and 15 matched control subjects. We hypothesized (i) hypofrontality in @entity0 in both tasks and (ii) decreased lateralization of prefrontal activation in @entity0 under the assumption that, in controls, left prefrontal cortex (PFC) is engaged preferentially in the verbal task (verbal domain dominance) and the right prefrontal cortex is engaged preferentially in the spatial task (spatial domain dominance). Our results showed no significant differences in frontal activation between controls and @entity0 , i.e. no hypofrontality in @entity0 , even at a very liberal threshold (p<0.01). This may be explained by the fact that nearly all @entity0 studied received atypical neuroleptics. Nonetheless, we found evidence for more subtle, domain-related @entity3 . Whereas controls showed verbal WM domain dominance in @entity1 and spatial WM domain dominance in right prefrontal cortex, these domain dominance effects were absent in the @entity0 group, i.e. there were no lateralization effects. Finally, only @entity0 showed an inverse correlation between performance and right prefrontal activation in verbal WM. We conclude that the finding of hypofrontality may depend on the medication of the @entity0 and that there is @entity3 even in the absence of hypofrontality.

title: No hypofrontality, but absence of prefrontal lateralization comparing @entity4 in XXXX .

answer: @entity2


abstract: UNASSIGNED: A sensitive and efficient method of high performance liquid chromatography using @entity10 ( @entity6 ) as pre-column derivatization reagent coupled with UV detection (HPLC-UV) and online mass spectrometry identification was established for determination of the most common @entity9 ( @entity1 ( @entity2 ) and @entity5 (GalNAc)) and @entity0 ( @entity8 ). In order to obtain the highest liberation level of the three @entity3 without destruction of @entity8 or conversion of @entity2 /GalNAc to GlcN/ @entity7 in the hydrolysis procedure, the pivotal parameters affecting the liberation of @entity9 / @entity8 from sample were investigated with response surface methodology (RSM). Under the optimized condition, maximum yield was obtained. The effects of key parameters on derivatization, separation and detection were also investigated. At optimized conditions, three @entity3 were labeled fast and entirely, and all derivatives exhibited a good baseline resolution and high detection sensitivity. The developed method was linear over the calibration range 0.25-12 M, with R(2)>0.9991. The detection limits of the method were between 0.48 and 2.01pmol. Intra- and inter-day precisions for the three @entity3 ( @entity2 , GalNAc and @entity8 ) were found to be in the range of 3.07-4.02% and 3.69-4.67%, respectively. Individual @entity4 recovery from spiked milk was in the range of 81%-97%. The sensitivity of the method, the facility of the derivatization procedure and the reliability of the hydrolysis conditions suggest the proposed method has a high potential for utilization in routine trace @entity9 and @entity8 analysis in biological samples.

title: A sensitive and efficient method for determination of XXXX and @entity0 in breast milk and milk-based products by high-performance liquid chromatography via UV detection and mass spectrometry identification.

answer: @entity9


abstract: UNASSIGNED: A sensitive and efficient method of high performance liquid chromatography using @entity10 ( @entity6 ) as pre-column derivatization reagent coupled with UV detection (HPLC-UV) and online mass spectrometry identification was established for determination of the most common @entity9 ( @entity1 ( @entity2 ) and @entity5 (GalNAc)) and @entity0 ( @entity8 ). In order to obtain the highest liberation level of the three @entity3 without destruction of @entity8 or conversion of @entity2 /GalNAc to GlcN/ @entity7 in the hydrolysis procedure, the pivotal parameters affecting the liberation of @entity9 / @entity8 from sample were investigated with response surface methodology (RSM). Under the optimized condition, maximum yield was obtained. The effects of key parameters on derivatization, separation and detection were also investigated. At optimized conditions, three @entity3 were labeled fast and entirely, and all derivatives exhibited a good baseline resolution and high detection sensitivity. The developed method was linear over the calibration range 0.25-12 M, with R(2)>0.9991. The detection limits of the method were between 0.48 and 2.01pmol. Intra- and inter-day precisions for the three @entity3 ( @entity2 , GalNAc and @entity8 ) were found to be in the range of 3.07-4.02% and 3.69-4.67%, respectively. Individual @entity4 recovery from spiked milk was in the range of 81%-97%. The sensitivity of the method, the facility of the derivatization procedure and the reliability of the hydrolysis conditions suggest the proposed method has a high potential for utilization in routine trace @entity9 and @entity8 analysis in biological samples.

title: A sensitive and efficient method for determination of @entity9 and XXXX in breast milk and milk-based products by high-performance liquid chromatography via UV detection and mass spectrometry identification.

answer: @entity0


abstract: @entity6 ( @entity6 ) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. @entity2 in @entity0 should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal @entity5 enhancement and subdural effusion. It may mimic central nervous system (CNS) @entity1 . Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the @entity5 enhancement as CNS @entity1 is an important issue. @entity3 is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. @entity6 might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic @entity0 suffering from @entity4 . We report a case of @entity6 during @entity3 treatment. @entity0 was completely well following drug discontinuation and supportive treatment.

title: @entity3 -related XXXX syndrome mimicking dural @entity1 in a breast cancer @entity0 : case report and review of the literature.

answer: @entity4


abstract: @entity6 ( @entity6 ) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. @entity2 in @entity0 should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal @entity5 enhancement and subdural effusion. It may mimic central nervous system (CNS) @entity1 . Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the @entity5 enhancement as CNS @entity1 is an important issue. @entity3 is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. @entity6 might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic @entity0 suffering from @entity4 . We report a case of @entity6 during @entity3 treatment. @entity0 was completely well following drug discontinuation and supportive treatment.

title: @entity3 -related @entity4 syndrome mimicking dural XXXX in a breast cancer @entity0 : case report and review of the literature.

answer: @entity1


abstract: @entity6 ( @entity6 ) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. @entity2 in @entity0 should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal @entity5 enhancement and subdural effusion. It may mimic central nervous system (CNS) @entity1 . Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the @entity5 enhancement as CNS @entity1 is an important issue. @entity3 is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. @entity6 might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic @entity0 suffering from @entity4 . We report a case of @entity6 during @entity3 treatment. @entity0 was completely well following drug discontinuation and supportive treatment.

title: XXXX -related @entity4 syndrome mimicking dural @entity1 in a breast cancer @entity0 : case report and review of the literature.

answer: @entity3


abstract: @entity6 ( @entity6 ) is an entity, which is secondary to iatrogenic manipulation and breaching of dura. @entity2 in @entity0 should be suspected, cranial magnetic resonance imaging (MRI) is essential for precise diagnosis. Hallmark of MRI is regular shape of pachymeningeal @entity5 enhancement and subdural effusion. It may mimic central nervous system (CNS) @entity1 . Prevention of such cases from receiving cranial radiotherapy by misinterpretation of the @entity5 enhancement as CNS @entity1 is an important issue. @entity3 is an antineoplastic agent, of which metabolites can cross blood-brain barrier in CNS via epithelial tissue. It may cause decrease in CSF production. @entity6 might be the clinical reflection of this decrease in CSF production. Review of the English literature revealed limited data because of the very little experience with oncologic @entity0 suffering from @entity4 . We report a case of @entity6 during @entity3 treatment. @entity0 was completely well following drug discontinuation and supportive treatment.

title: @entity3 -related @entity4 syndrome mimicking dural @entity1 in a breast cancer XXXX : case report and review of the literature.

answer: @entity0


abstract: A new @entity0 model of porcine @entity4 ( @entity4 ) xenograft rejection, avoiding interference of unspecific @entity1 , was introduced and used to investigate rejection mechanisms. Athymic (nu/nu) @entity0 were transplanted with syngeneic, allogeneic, or xenogeneic islets under the kidney capsule. After the original transplantation, immune cells in porcine @entity4 xenografts undergoing rejection in native immunocompetent @entity0 were transferred to the peritoneal cavity of the athymic @entity0 . At defined time points after transfer, the primary grafts were evaluated by immunohistochemistry and real-time quantitative RT-PCR to estimate cytokine and chemokine mRNA expression. Transfer of immunocompetent cells enabled athymic (nu/nu) @entity0 to reject a previously tolerated @entity4 xenograft only when donor and recipient were matched for major histocompatibility complex (MHC). In contrast, allogeneic and syngeneic islets were not rejected. The @entity4 xenograft rejection was mediated by transferred T-cells. The main effector cells, macrophages, were shown to be part of a specific immune response. By day 4 after transplantation, there was an upreglation of both @entity3 - and @entity2 -associated cytokine transcripts. The transferred T-cells were xenospecific and required MHC compatibility to induce rejection. Interaction between the TCR of transferred T-cells and MHC on host endothelial cells and/or macrophages seems necessary for inducing @entity4 xenograft rejection.

title: A new XXXX model of islet xenograft rejection: graft destruction is dependent on a major histocompatibility-specific interaction between T-cells and macrophages.

answer: @entity0


abstract: OBJECTIVES: @entity6 ( @entity6 ), is an @entity2 due to missense mutations in the @entity5 ( @entity5 ) gene encoding nuclear lamina proteins. It is characterized by loss of subcutaneous fat from the extremities and trunk and accumulation of fat in the head and neck region beginning at puberty. @entity0 with @entity6 are predisposed to metabolic complications of insulin resistance such as @entity1 . We sought to identify risk factors for @entity1 in @entity0 with @entity6 . RESEARCH DESIGN AND METHODS: A cross-sectional study comparing clinical, biochemical, and anthropometric variables and @entity5 genotypes in @entity6 @entity0 with and without @entity1 . RESULTS: We studied 52 @entity0 and 24 @entity0 with @entity6 from 18 different families. Twenty-eight @entity0 (54%) but only four @entity0 (17%) had @entity1 (P < 0.001); therefore further comparisons were mostly limited to @entity0 . Compared with @entity0 without @entity1 , those with @entity1 had higher BMI (median values 23 vs. 24 kg/m(2), respectively; P = 0.03), increased chin skinfold thickness (10 vs. 20 mm; P = 0.001), lower rates of nulliparity (60% vs. 28%; P = 0.04), and higher levels of fasting serum @entity4 (2.4 vs. 3.5 mmol/l; P < 0.001) but similar serum @entity3 levels (3.4 vs. 3.6 ng/ml; P = 0.9). The prevalence of @entity1 was not related to age, menopausal status, family history of type 2 @entity1 in unaffected relatives, or @entity5 genotype. CONCLUSIONS: We conclude that increased adiposity as reflected by excess subcutaneous fat accumulation in the chin region and parity may predispose @entity0 with @entity6 to develop @entity1 .

title: Risk factors for XXXX , Dunnigan variety.

answer: @entity1


abstract: OBJECTIVES: Percutaneous closure of secundum @entity1 ( @entity1 ) has become an important alternative treatment to surgery. We evaluated our clinical experience with, and short-term results of transcatheter closure of ASDs with the Amplatzer septal occluder in adult @entity0 . STUDY DESIGN: The study included 52 @entity0 (36 @entity0 , 16 @entity0 ; mean age 33  14 years; range 14 to 69 years) who underwent transcatheter @entity1 closure with the Amplatzer occluder device. The mean @entity1 diameter measured by transesophageal echocardiography was 19.5  5.7 mm and the mean device diameter was 24.5  5.7 mm. All the @entity0 were assessed clinically and echocardiographically one month after the procedure. RESULTS: Transcatheter @entity1 closure was successfully performed in 48 @entity0 (92.3%) and failed in four @entity0 (7.7%). Echocardiographic controls showed significant decreases in @entity4 , @entity5 , and pulmonary artery pressure (p=0.003, p=0.026, and p=0.0001, respectively). Functional capacity of the @entity0 also showed significant improvements (p=0.0001). After implantation, residual shunts were detected in four @entity0 , all of which disappeared one month after the procedure. Major complications were seen in two @entity0 . One @entity0 developed @entity7 immediately after the procedure due to device embolization. One @entity0 with @entity6 developed device @entity2 due to cessation of dual antiplatelet therapy, which was successfully treated by anticoagulation therapy. @entity3 was not observed in any @entity0 . CONCLUSION: Percutaneous closure of secundum ASDs with the Amplatzer occluder device is a safe and effective procedure with a high success rate.

title: [Closure of secundum XXXX by the Amplatzer occluder device].

answer: @entity1


abstract: BACKGROUND: Malignant @entity2 (MPM) is a rare but aggressive @entity1 that develops by mesothelial cell transformation. At present, there are no effective therapies for MPM. Great efforts have been made in finding specific markers/mechanisms for MPM onset, including studies into microRNAs (miRNAs). Recent studies have shown the differential expression of mature miRNAs in several @entity0 @entity1 , suggesting their potential role as oncogenes or @entity1 suppressor genes. METHODS: In this study, we investigated miRNAs profile in five @entity0 normal pleural mesothelial short-term cell cultures (HMCs) and five MPMs, with microarray approach. These results were confirmed by real-time quantitative reverse-transcriptase polymerase chain reaction and Western blotting. RESULTS: A comparative analysis of miRNA expression in MPM and HMCs was carried out. Microarray profiling showed different miRNA expression between MPM and HMCs. Specifically, members of the oncomiRNA @entity3 cluster and its paralogs, namely @entity5 , 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated. Besides, in our investigation, additional miRNAs, such as @entity4 , @entity7 , @entity6 , and @entity8 were found to be dysregulated in MPM. CONCLUSIONS: These data are in agreement with results that have previously been reported on dysregulated miRNAs for other solid @entity0 @entity1 . Moreover, in our investigation, additional miRNAs were found to be dysregulated in MPM. Interestingly, gene products that regulate the cell cycle are targets and predicted targets for these miRNAs. Our data suggest that specific miRNAs could be key players in MPM development/progression. In addition, some of these miRNAs may represent MPM markers and potential targets for new therapeutic approaches.

title: MicroRNAs dysregulation in XXXX malignant pleural mesothelioma.

answer: @entity0


abstract: @entity5 are extremely rare in the skin. When they involve the skin, it is usually by upward spread from a subcutaneous or deeper seated @entity5 . Very rarely, @entity5 @entity1 to the skin or arise as a primary @entity4 . We describe 2 cases of atypical @entity2 "well-differentiated @entity5 " located in dermis. Both presented clinically as a skin tag. The @entity2 arose in a 56-year-old female and a 69-year-old male @entity0 . Both lesions were treated by excision and reexcision. In addition to classical morphology of atypical @entity2 with evidence of lipoblasts and atypical adipocytes, immunohistochemistry with nuclear @entity3 double-minute type 2 protein and @entity6 expression as well as fluorescence in situ hybridization analysis showing an amplification of @entity3 double-minute type 2 protein and @entity6 were helpful to establish the diagnosis. None of the cases recurred after surgical treatment. These 2 cases show the importance of not to misdiagnose lesions which clinically may appear to be benign.

title: Atypical XXXX " of the skin clinically presenting as a skin tag: clinicopathologic, immunohistochemical, and molecular analysis of 2 cases.

answer: @entity2


abstract: BACKGROUND: Biphasic waveform shocks are more effective than monophasic shocks for @entity1 , @entity3 , and defibrillation with implantable defibrillators but have not been studied for open @entity2 . This prospective, blinded, randomized clinical study compares biphasic and monophasic shock effectiveness and establishes intraoperative energy dose-response curves. METHODS: @entity0 undergoing cardiothoracic surgery with bypass cardioplegia were randomly assigned to the monophasic or biphasic shock group. @entity5 occurring after aortic clamp removal was treated with escalating energies of 2, 5, 7, 10, and 20 J until defibrillation occurred. If @entity5 persisted, a 20-J crossover shock of the other waveform was used. RESULTS: Cumulative defibrillation success at 5 J, the primary end point of the study, was higher in the biphasic group than in the monophasic group (25 of 50 vs. 9 of 41 defibrillated; P = 0.011). In addition, the biphasic group required lower threshold energy (6.8 vs. 11.0 J; P = 0.003), less cumulative energy (12.6 vs. 23.4 J; P = 0.002), and fewer shocks (2.5 vs. 3.5; P = 0.002). Crossover-shock effectiveness did not differ between groups. Dose-response curves show biphasic shocks to have higher cumulative success rates at all energies tested. CONCLUSIONS: @entity4 are substantially more effective than monophasic shocks for direct defibrillation. The dose-response curve guides selection of first-shock energy for traditional step-up protocols. Starting at 5 J optimizes for lowest threshold and cumulative energy, whereas 10 or 20 J optimizes for more rapid defibrillation and fewer shocks.

title: XXXX compared with monophasic damped sine wave shocks for direct ventricular defibrillation during open heart surgery.

answer: @entity4


abstract: INTRODUCTION: @entity5 ( @entity5 ) is a @entity8 caused by deficiency of a-l-iduronidase. The otolaryngological findings include @entity2 , @entity10 , recurrent @entity9 , @entity3 and adenoid, recurrent rhinosinusitis, @entity12 , snoring, oral breathing and nasal obstruction. OBJECTIVE: To evaluate the impact of enzymatic replacement therapy with laronidase (Aldurazyme(  )) in @entity0 with @entity5 ( @entity14 ), regarding sleep and @entity7 , and clinical manifestations in the upper respiratory tract (URT). METHODS: Nine @entity0 with @entity14 (8 @entity14 , and 1 Scheie phenotypes) of both sexes, ages ranging between 3 and 20 years, were included in this study. @entity0 were evaluated between seven and 11 months before the treatment and between 16 and 22 months after the onset of the enzymatic replacement. They were all submitted to a clinical and otolaryngological evaluation, including nasofibroscopical, polysomnographic and audiologic exams. RESULTS: The results' data showed decreasing of the frequency of ear, nose and @entity1 , with improvement of the @entity11 and @entity4 . No remarkable changes were observed regarding @entity13 and tonsil and @entity3 . Audiometric and polysomnographic evaluations did not show statistical significance. CONCLUSION: Enzymatic replacement therapy in @entity0 with @entity14 provides control of recurrent @entity6 , @entity11 and @entity4 , however it is does not seem to improve audiologic and polisomnographic parameters, with no effect on adenoid and tonsils @entity3 and @entity13 .

title: The impact of laronidase treatment in otolaryngological manifestations of @entity0 with XXXX .

answer: @entity5


abstract: INTRODUCTION: @entity5 ( @entity5 ) is a @entity8 caused by deficiency of a-l-iduronidase. The otolaryngological findings include @entity2 , @entity10 , recurrent @entity9 , @entity3 and adenoid, recurrent rhinosinusitis, @entity12 , snoring, oral breathing and nasal obstruction. OBJECTIVE: To evaluate the impact of enzymatic replacement therapy with laronidase (Aldurazyme(  )) in @entity0 with @entity5 ( @entity14 ), regarding sleep and @entity7 , and clinical manifestations in the upper respiratory tract (URT). METHODS: Nine @entity0 with @entity14 (8 @entity14 , and 1 Scheie phenotypes) of both sexes, ages ranging between 3 and 20 years, were included in this study. @entity0 were evaluated between seven and 11 months before the treatment and between 16 and 22 months after the onset of the enzymatic replacement. They were all submitted to a clinical and otolaryngological evaluation, including nasofibroscopical, polysomnographic and audiologic exams. RESULTS: The results' data showed decreasing of the frequency of ear, nose and @entity1 , with improvement of the @entity11 and @entity4 . No remarkable changes were observed regarding @entity13 and tonsil and @entity3 . Audiometric and polysomnographic evaluations did not show statistical significance. CONCLUSION: Enzymatic replacement therapy in @entity0 with @entity14 provides control of recurrent @entity6 , @entity11 and @entity4 , however it is does not seem to improve audiologic and polisomnographic parameters, with no effect on adenoid and tonsils @entity3 and @entity13 .

title: The impact of laronidase treatment in otolaryngological manifestations of XXXX with @entity5 .

answer: @entity0


abstract: OBJECTIVES: @entity2 ( @entity2 ) continues to be the most important bacterial cause of @entity1 , meningitidis in newborns. American consensus guidelines have been published. They recommended the use of either risk-based strategy or screening-based approach for @entity2 colonization in pregnant @entity0 to identify candidates for intrapartum prophylaxis. Screening consists of obtaining vaginal and anorectal specimens for culture at 35 to 37 weeks' gestation. The aim of this prospective study was to assess the usefulness of systematic and concomitant @entity2 screening by rectal and vaginal swab in pregnant @entity0 . A questionnaire designed to determine the risk factors for colonization by @entity2 was completed. MATERIALS AND METHODS: We have screened 370 pregnant @entity0 with rectal and vaginal swab. RESULTS: Fifty seven (15.4%) @entity0 had positive @entity2 cultures. Of those @entity0 , the rectum and the vagina were the only site of colonization in 16 (4.3%) and 8 (2.2%) @entity0 respectively. None of the factors studied was significantly associated with @entity2 colonization. CONCLUSION: Detection of @entity2 is enhanced by 40% by using vaginal and anorectal swabs compared to a vaginal swab alone. No studied factor appeared to predict @entity2 colonization, which incited us to screen all pregnant @entity0 .

title: [Risk factors and screening strategy for group B streptococcal colonization in pregnant XXXX : results of a prospective study].

answer: @entity0


abstract: UNASSIGNED: In this paper I describe through detailed clinical material the challenges posed by @entity0 who employ entangled @entity2 defenses. I discuss the complicated nature of treating a @entity0 who employed entangled @entity2 defenses and utilized my voice in an effort to preserve an undifferentiated state of dual unity. My @entity0 's pursuit of dual unity took a very concrete form in her attempt to mitigate the terror of separateness. This concreteness was expressed via the @entity0 's urgent request that I read letters she wrote to me between sessions. This type of @entity2 placed great strain on my ability to think analytically and I also became increasingly concrete in my response to the @entity0 . Crucial to the analyst's regaining a space in which to think and a sense of separateness is the ability to contact the ground floor of her separate bodily experience. This is just the beginning step in the analyst separating herself from the powerful press to join the @entity0 in a state of dual unity. Interpretation in action (Ogden, 1994) was an effective way to convey the importance of creating and tolerating internal space in myself and begin to create internal space in the @entity0 . Previously such space had been closed down in order to manage primitive fears of annihilation. When a @entity0 is absorbed in an entangling @entity2 retreat words do not reach the @entity0 on a symbolic level but rather are experienced primarily as an assault on the need for dual unity with the analyst. The @entity0 's need to be wrapped in a sensation based world of dual unity is preferable to a world of spoken words that carry the danger of delineating @entity1 . In essence there is no self to speak words, only a whirl of an amorphous sensation self lacking definition. I believe with certain kinds of @entity0 it may be necessary to first lose and then work to regain one's analytic mind, as I have powerfully described in the case of Linda. Linda's profound loss of connection to the ground floor of her experience could only begin to be addressed when I worked to extricate myself from 'our magic carpet ride' of dual unity, contacting the reality of my bodily experience, and begin to tolerate the terror I felt regarding my separateness from Linda. I also describe the confusing vacillation between entangled and encapsulated defenses in @entity0 like Linda as previously identified by Cohen and Jay (1996). Ultimately, this kind of slow difficult analytic work began to help Linda develop a capacity to think and provided an alternative to the deadened world of her @entity2 protections.

title: The use of the analyst as an XXXX shape.

answer: @entity2


abstract: UNASSIGNED: @entity10 ( @entity10 ) are a group of @entity1 causing progressive @entity3 . Over 50 genes have now been associated with HSP. Despite the recent explosion in genetic knowledge, HSP remains without pharmacological treatment. Loss-of-function mutation of the @entity11 gene, also known as @entity11 , is the most common cause of HSP in @entity0 . @entity11 is conserved across animal species and regulates microtubule dynamics. Recent studies have shown that it also modulates endoplasmic reticulum (ER) stress. Here, utilizing null @entity11 homologues in @entity6 , @entity2 , and @entity7 , we tested FDA approved compounds known to modulate ER stress in order to ameliorate locomotor phenotypes associated with HSP. We found that @entity4 found in all of our spastin models could be partially rescued by @entity12 , @entity8 , @entity5 , @entity9 and salubrinal. In addition, we show that established biomarkers of ER stress levels correlated with improved locomotor activity upon treatment across model organisms. Our results provide insights into biomarkers and novel therapeutic avenues for HSP.

title: Conserved pharmacological rescue of XXXX -related phenotypes across model organisms.

answer: @entity10


abstract: MicroRNAs are endogenous small non-coding RNAs that regulate gene expression and @entity1 development. A rare population of @entity2 stem cells (HSCs) holds the extensive proliferative and self-renewal potential necessary to form a @entity2 . We postulated that specific transcriptional factors might regulate the expression of microRNAs and subsequently modulate the expression of gene products involved in phenotypic characteristics of HSCs. We evaluated the expression of microRNA in @entity0 HSCs by microarray profiling, and defined the target genes and functional effects of two groups of microRNA regulated by @entity5 and transcriptional factor Twist. A subset of highly chemoresistant and invasive HSCs was screened with aberrant expressions of cytokine @entity5 and Twist. We demonstrated that conserved let-7 and miR-181 family members were up-regulated in HSCs by global microarray-based microRNA profiling followed by validation with real-time polymerase chain reaction. Importantly, inhibition of let-7 increases the chemosensitivity of HSCs to @entity6 and @entity4 whereas silencing of miR-181 led to a reduction in HSCs motility and invasion. Knocking down @entity5 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion. We showed that let-7 directly targets @entity7 and @entity3 , whereas miR-181 directly targets @entity10 , @entity8 as well as @entity9 ( @entity9 ). In conclusion, alterations of @entity5 - and Twist-regulated microRNA expression in HSCs play a part in @entity1 spreading and responsiveness to chemotherapy. Our results define a novel regulatory mechanism of let-7/miR-181s suggesting that let-7 and miR-181 may be molecular targets for eradication of hepatocellular @entity1 .

title: Functional analysis of microRNAs in @entity0 XXXX stem cells.

answer: @entity2


abstract: MicroRNAs are endogenous small non-coding RNAs that regulate gene expression and @entity1 development. A rare population of @entity2 stem cells (HSCs) holds the extensive proliferative and self-renewal potential necessary to form a @entity2 . We postulated that specific transcriptional factors might regulate the expression of microRNAs and subsequently modulate the expression of gene products involved in phenotypic characteristics of HSCs. We evaluated the expression of microRNA in @entity0 HSCs by microarray profiling, and defined the target genes and functional effects of two groups of microRNA regulated by @entity5 and transcriptional factor Twist. A subset of highly chemoresistant and invasive HSCs was screened with aberrant expressions of cytokine @entity5 and Twist. We demonstrated that conserved let-7 and miR-181 family members were up-regulated in HSCs by global microarray-based microRNA profiling followed by validation with real-time polymerase chain reaction. Importantly, inhibition of let-7 increases the chemosensitivity of HSCs to @entity6 and @entity4 whereas silencing of miR-181 led to a reduction in HSCs motility and invasion. Knocking down @entity5 and Twist in HSCs significantly reduced let-7 and miR-181 expression and subsequently inhibited chemoresistance and cell invasion. We showed that let-7 directly targets @entity7 and @entity3 , whereas miR-181 directly targets @entity10 , @entity8 as well as @entity9 ( @entity9 ). In conclusion, alterations of @entity5 - and Twist-regulated microRNA expression in HSCs play a part in @entity1 spreading and responsiveness to chemotherapy. Our results define a novel regulatory mechanism of let-7/miR-181s suggesting that let-7 and miR-181 may be molecular targets for eradication of hepatocellular @entity1 .

title: Functional analysis of microRNAs in XXXX @entity2 stem cells.

answer: @entity0


abstract: BACKGROUND: @entity8 is one of the most common infectious agents causing central nervous system (CNS) @entity3 in immunocompromised @entity0 . @entity0 with CNS @entity9 commonly present with non-specific manifestations such as @entity1 , @entity2 , @entity5 and conscious disturbance. This article presents the @entity11 ( @entity11 ) and magnetic resonance images (MRI) findings of @entity3 in CNS and displays the image difference between immunocompromised and non-immunocompromised @entity0 . METHODS: CNS @entity3 was found in 26 cases over the past 14 years in Taipei Veterans General Hospital, including 18 males and 8 females. Ten @entity0 were immunocompromised. In all cases, the CNS @entity9 was diagnosed by positive cryptococcal antigen titer and India ink stain from cerebral spinal fluid (CSF). Their clinical data and findings from @entity11 and MRI were retrospectively studied. RESULTS: The most common @entity11 manifestation is @entity10 ; other common findings include leptomeningeal enhancement, @entity7 (half of them revealed dilatation of Virchow-Robin spaces in subsequent MRI study) and normal appearance. Less common findings are @entity12 and @entity6 formation. The most common MRI pattern is Virchow-Robin space dilatation and leptomeningeal enhancement. Other common appearance includes @entity10 . Less common manifestations include cryptococcoma, @entity4 and pontine @entity6 . There is no significant difference in image patterns between immunocompromised and non-immunocompromised @entity0 (p > 0.05). CONCLUSIONS: The most common pattern ofCNS @entity9 is @entity10 in @entity11 and Virchow-Robin space dilatation in MRI. MRI is more sensitive in detecting CNS @entity3 like Virchow-Robin space dilatation and leptomeningeal enhancement. There is no significant pattern difference between immunocompromised and non-immunocompromised @entity0 with CNS @entity9 .

title: Radiological manifestations of XXXX in central nervous system.

answer: @entity3


abstract: STUDY DESIGN: Retrospective study OBJECTIVE: The authors' aim of the present study is to report their experience with subaxial cervical @entity2 hoping to provide further insight into these lesions including the presenting symptoms, possible mechanisms of cyst development associated with cervical level, surgical treatments and clinical outcomes. SUMMARY OF BACKGROUND DATA: @entity2 are relatively common in the lumbar spine and very uncommonly identified in the subaxial cervical spine. Several case reports and a few small series have been reported in the literature over the past four decades. METHODS: The authors retrospectively reviewed the cases of 35 @entity0 who underwent surgical treatment for histologically confirmed symptomatic subaxial cervical @entity2 between 1993 and 2009. The presenting symptoms, age, sex, cervical level, operation, complications and outcomes were analyzed in this cohort. Preoperative and postoperative neurologic assessments were done by staff neurologists independent of the operating surgeon. This study was approved by the Mayo Clinic institutional review board. RESULTS: Thirty-five @entity0 underwent surgical treatment for their @entity2 and follow-up for at least 12 months postoperatively. The mean follow-up time was 49 months (range, 12-134). There were no deaths associated with the surgery. There was one @entity1 in a @entity0 undergoing a decompressive laminectomy and posterior instrumented fusion. @entity0 outcomes were assessed using the Modified Rankin Score for 12 @entity0 was 0, 17 @entity0 was 1, 4 @entity0 was 2, and 2 @entity0 was 3. CONCLUSION: This series of 35 @entity0 with subaxial cervical @entity2 surgically treated over a period of 17 years illustrates the relative rarity of these lesions. Magnetic resonance imaging is currently the optimal radiographic study to identify these lesions. Surgical resection can be an effective treatment.

title: Subaxial cervical XXXX : report of 35 histologically confirmed surgically treated cases and review of the literature.

answer: @entity2


abstract: According to international standards, reference values for biochemical tests should be obtained in disease-free subjects and for therapies that may influence measurement values. For elderly @entity0 , especially the very old, such a requirement is difficult to meet, since few of these individuals are free of ongoing or former diseases. The present study of a population-based Swedish twin sample comprises 535 individuals (186 males, 349 females) who were at least 82 years of age at blood sampling. Survival over a 6-year period is used as a reference of overall health. Baseline test values for subjects surviving 6 years are compared with results for @entity0 who died in the follow-up period. Results, including mean and median values, standard deviations and ranges, were given for both genders in the total sample. Cases outside the 5th and 95th percentiles were then excluded, as were those who died during the follow-up period. In a third step, cases with disorders and therapies known to influence measurement values were also excluded. The risk of dying during the observation period was calculated across measurements from the lowest and highest 10th and 20th percentiles. The specific impact of proximity to @entity2 on the biochemical values, in addition to age effects, was analysed by comparing co-twins discordant for survival over 7 years. Increased mortality was indicated for subjects of both genders with high serum levels of @entity3 , urate, gamma-GT, free thyroxin and plasma @entity4 . In females, low serum values for albumin and total @entity1 were associated with increased mortality. A lower @entity1 level was found 4 years before @entity2 , while a lower HDL- @entity1 level was associated with an increased risk of @entity2 across the entire 7-year period.

title: Biochemical values in XXXX older than 82 years of age: report from a population-based study of twins.

answer: @entity0


abstract: Repetitive @entity2 to the hypothenar eminence can cause the ulnar artery to become @entity3 to the digital arteries. The symptoms and signs are also known as the @entity4 . We postulate that an arterial autograft is a superior conduit to the traditional vein graft. In this article, we report 3 cases (2 in 1 @entity0 ) of reconstruction of the distal ulnar artery with the descending branch of the lateral circumflex femoral artery (LCFA). Two @entity0 , ages 45 to 50 years, had severe @entity1 complaints of the ulnar fingers. Arteriograms confirmed occlusion of the distal ulnar artery without direct perfusion of the superficial palmar arch. All reconstructions were carried out with the descending branch of the LCFA. From the ulnar artery at wrist level to the superficial palmar arch and the involved common digital arteries. Patency was certified during follow-up with color-coded Duplex sonography at 6 to 28 months. Preoperative complaints like cold intolerance and other @entity1 disappeared.

title: XXXX : distal ulnar artery reconstruction with autologous descending branch of the lateral circumflex femoral artery.

answer: @entity4


abstract: @entity4 are rare congenital lesions which often have associated skeletal changes. Over a period of ten years, 90 @entity0 at our clinic had a @entity3 of the lower limb, examined by either CT or MRI. Of these, 18 (20%) had bony involvement. A questionnaire was sent to these @entity0 (8 @entity0 , 10 @entity0 ) to evaluate their age of presentation, initial symptoms and current complaints. Radiological imaging revealed 15 low- and three high-flow lesions. The mean age at presentation to a physician was six years of age. @entity2 was the most common complaint. Disparity in leg length of 2 cm or more was observed in ten @entity0 . Of the 16 @entity0 with @entity1 , 13 had four or more muscles involved. Treatment by resection alone would require radical surgery.

title: XXXX of the lower limb with osseous involvement.

answer: @entity4


abstract: OBJECTIVE: To describe a new @entity1 clip prosthesis for partial ossicular reconstruction with a micro ball joint in the headplate for compensation of tympanic membrane displacements. @entity0 : Laboratory experiments followed by 18 consecutive @entity0 . INTERVENTIONS: A micro ball joint was implemented into a headplate of @entity1 middle ear prosthesis. First, the new prosthesis was tested in the laboratory in temporal bone experiments. Second, the new prosthesis was clinically installed in 18 @entity0 . OUTCOME MEASURES: Results of laser Doppler vibrometry and force measurements in the laboratory experiments, analysis of a questionnaire, and preoperative and postoperative pure tone audiometry. RESULTS: The frictional resistance in the joint was measured to be 12 mN that should allow for adequate mobility under physiologic conditions. The effective sound transmission of the prosthesis was demonstrated by laser Doppler vibrometry. Intraoperatively, the installation of the prosthesis was always straightforward with headplate prosthesis shaft angles between 60 and 90 degrees. Postoperatively, pure tone audiometry revealed satisfying hearing results with a remaining average air-bone gap of 18.2 dB over the frequencies 500, 1,000, 2,000, and 3,000 Hz. No signs of @entity2 were discovered within the follow-up period of approximately 6 months. CONCLUSION: The experimental data show that the new modified prosthesis headplate fulfills the requirements necessary for sound transmission. The joint allows the plate to follow movements of the tympanic membrane. This characteristic in conjunction with the proven clip design ensure for optimal prosthesis placement and effectiveness.

title: XXXX clip ball joint: a partial ossicular reconstruction prosthesis.

answer: @entity1


abstract: BACKGROUND: Aphasia affects 1/3 of @entity1 @entity0 with improvements noted only in some of them. The goal of this exploratory study was to provide preliminary evidence regarding safety and efficacy of fMRI-guided excitatory repetitive transcranial magnetic stimulation (rTMS) applied to the residual left-hemispheric Broca's area for chronic @entity2 treatment. MATERIAL/METHODS: We enrolled 8 @entity0 with moderate or severe @entity2 >1 year after @entity1 . Linguistic battery was administered pre-/post-rTMS; a semantic decision/tone decision (SDTD) fMRI task was used to localize left-hemispheric Broca's area. RTMS protocol consisted of 10 daily treatments of 200 seconds each using an excitatory stimulation protocol called intermittent theta burst stimulation (iTBS). Coil placement was targeted individually to the left Broca's. RESULTS: 6/8 @entity0 showed significant pre-/post-rTMS improvements in semantic fluency (p=0.028); they were able to generate more appropriate words when prompted with a semantic category. Pre-/post-rTMS fMRI maps showed increases in left fronto-temporo-parietal language networks with a significant left-hemispheric shift in the left frontal (p=0.025), left temporo-parietal (p=0.038) regions and global language LI (p=0.018). @entity0 tended to report subjective improvement on Communicative Activities Log (mini-CAL; p=0.075). None of the subjects reported ill effects of rTMS. CONCLUSIONS: FMRI-guided, excitatory rTMS applied to the affected Broca's area improved language skills in @entity0 with chronic post- @entity1 @entity2 ; these improvements correlated with increased language lateralization to the left hemisphere. This rTMS protocol appears to be safe and should be further tested in blinded studies assessing its short- and long-term safety/efficacy for post- @entity1 @entity2 rehabilitation.

title: Excitatory repetitive transcranial magnetic stimulation induces improvements in chronic post- @entity1 XXXX .

answer: @entity2


abstract: BACKGROUND: Aphasia affects 1/3 of @entity1 @entity0 with improvements noted only in some of them. The goal of this exploratory study was to provide preliminary evidence regarding safety and efficacy of fMRI-guided excitatory repetitive transcranial magnetic stimulation (rTMS) applied to the residual left-hemispheric Broca's area for chronic @entity2 treatment. MATERIAL/METHODS: We enrolled 8 @entity0 with moderate or severe @entity2 >1 year after @entity1 . Linguistic battery was administered pre-/post-rTMS; a semantic decision/tone decision (SDTD) fMRI task was used to localize left-hemispheric Broca's area. RTMS protocol consisted of 10 daily treatments of 200 seconds each using an excitatory stimulation protocol called intermittent theta burst stimulation (iTBS). Coil placement was targeted individually to the left Broca's. RESULTS: 6/8 @entity0 showed significant pre-/post-rTMS improvements in semantic fluency (p=0.028); they were able to generate more appropriate words when prompted with a semantic category. Pre-/post-rTMS fMRI maps showed increases in left fronto-temporo-parietal language networks with a significant left-hemispheric shift in the left frontal (p=0.025), left temporo-parietal (p=0.038) regions and global language LI (p=0.018). @entity0 tended to report subjective improvement on Communicative Activities Log (mini-CAL; p=0.075). None of the subjects reported ill effects of rTMS. CONCLUSIONS: FMRI-guided, excitatory rTMS applied to the affected Broca's area improved language skills in @entity0 with chronic post- @entity1 @entity2 ; these improvements correlated with increased language lateralization to the left hemisphere. This rTMS protocol appears to be safe and should be further tested in blinded studies assessing its short- and long-term safety/efficacy for post- @entity1 @entity2 rehabilitation.

title: Excitatory repetitive transcranial magnetic stimulation induces improvements in chronic post- XXXX @entity2 .

answer: @entity1


abstract: In cytology studies false negative smears range from 1.8% to 20% due to different levels of cytologic expertise and of material presented to the pathologist. Only 6% of in situ @entity2 of the cervix have an abnormal gross appearance so routine multiple biopsies are needed. Schiller's test, using a weak aqueous solution of @entity5 , leaves an area of @entity2 unstained but colors normal cervical epithelium a dark brown. However, not all areas which fail to stain represent foci of @entity1 . Multiple biopsies and endocervical curettage are required, particularly to detect lesions not involving the portio. Conization is the most accurate method for evaluating the suspicious cervix. 80 histo logic sections should be examined from each cervix specimen. Complicati ons of conization may be @entity3 , @entity4 , uterine perforation, and @entity6 . Only after 4-6 weeks does @entity6 cease to be a significant risk. When done during pregnancy, conization may cause a fetal loss of 15%. Colposcopy has a low false-negative rate but cannot detect lesions inside the cervical canal. It is the best method of clinical evaluation of @entity0 with abnormal cytological smears, particularly during pregnancy. A colposcopic diagnosis is based on an evaluation of vascular pattern, intercapillary distance, surface contour, color tone, and clarity of demarcation. Where colposcopic examination is unsatisfactory and cytology is positive, conization is indicated. The final diagnosis depends on the histology of the directed biopsy.

title: Detection of cervical XXXX : reducing the risk of error.

answer: @entity1


abstract: BACKGROUND: The cognitive neural underpinnings of prototype learning are becoming clear. Evidence points to 2 different neural systems, depending on the learning parameters. @entity1 ( @entity1 ) prototype learning is mediated by posterior brain regions that are involved in early perceptual learning, whereas A/B (AB) is mediated by frontal and medial temporal lobe regions. STUDY OBJECTIVES: To investigate the effects of @entity2 on @entity1 and @entity3 and to use established prototype models to provide insights into the cognitive-processing locus of @entity2 . DESIGN: @entity0 performed an @entity1 and an @entity3 task twice, separated by a 24-hour period, with or without sleep between testing sessions. @entity0 : Eighteen West Point cadets participated in the @entity2 group, and 17 West Point cadets participated in a control group. MEASUREMENTS AND RESULTS: Sleep deprivation led to an @entity1 , but not an AB, performance deficit. Prototype model analyses indicated that the @entity1 was due to changes in attentional focus and a decrease in confidence that is reflected in an increased bias to respond non-A. CONCLUSIONS: The findings suggest that @entity1 , but not AB, prototype learning is affected by @entity2 . Prototype model analyses support the notion that the effect of @entity2 on @entity1 is consistent with lapses in attentional focus that are more detrimental to @entity1 than to AB. This finding adds to a growing body of work that suggests that different performance changes associated with @entity2 can be attributed to a common mechanism of changes in simple attention and vigilance.

title: The effects of XXXX on dissociable prototype learning systems.

answer: @entity2


abstract: OBJECTIVE: To evaluate the prevalence of respiratory symptoms, @entity5 and immediate @entity0 in a population exposed to flour and cereal dusts in five flour mills in Morocco. METHODS: The study of 373 exposed and 301 non-exposed subjects consisted of an analysis of working conditions and a medical survey. RESULTS AND CONCLUSION: The prevalence of clinical respiratory symptoms was 64.1% among exposed subjects and 41.2% among non-exposed subjects. Cough, expectoration, @entity6 , @entity4 , @entity3 , @entity2 and chronic @entity7 were more frequent among mill-workers. Spirometry was abnormal in 31.6% of those exposed: anomalies were found in both flow and volume. Among exposed subjects with a @entity1 , 77.9% had only small airways syndrome or a light deficit. Smoking was the cause of excess morbidity. Skin prick tests were positive for at least one allergen in 65.4% of exposed compared to 27.2% non-exposed subjects. The prevalence of positive skin tests to occupational allergens alone was higher among those exposed (42.4%) than among the non-exposed (9.9%). The implementation of adequate medical and technical prevention may reduce this risk.

title: [The prevalence of respiratory symptomes and immediate XXXX in a population exposed to flour and cereal dust in five flour mills in Morocco].

answer: @entity0


abstract: A brief overview and comparison is given of dose rates arising from natural background radiation and the fallout from atmospheric testing of nuclear weapons. Although there are considerable spatial variations in exposure to natural background radiation, it is useful to give estimates of worldwide average overall exposures from the various components of that background. Cosmic-ray secondaries of low linear energy transfer (LET), mainly muons and photons, deliver about 280 microSv a(-1). Cosmic-ray neutrons deliver about another 100 microSv a(-1). These low- and high-LET exposures are relatively uniform to the whole body. The effective dose rate from cosmogenic radionuclides is dominated by the contribution of 12 microSv a(-1) from @entity3 . This is due to relatively uniform irradiation of all organs and tissues from low-energy beta particles. Primordial radionuclides and their progeny (principally the 238U and 232Th series, and @entity5 ) contribute about 480 microSv a(-1) of effective dose by external irradiation. This is relatively uniform photon irradiation of the whole body. Internally incorporated @entity5 contributes a further 165 microSv a(-1) of effective dose in adults, mainly from beta particles, but with a significant gamma component. Equivalent doses from @entity5 are somewhat higher in muscle than other soft tissues, but the distinction is less than a factor of three. @entity1 and @entity4 series radionuclides give rise to an average effective dose rate of around 120 microSv a(-1). This includes a major alpha particle component, and exposures of radiosensitive tissues in lung, liver, kidney and the skeleton are recognised as important contributors to effective dose. Overall, these various sources give a worldwide average effective dose rate of about 1160 microSv a(-1). Exposure to 222Rn, 220Rn and their short-lived progeny has to be considered separately. This is very variable both within and between countries. For 222Rn and its progeny, a worldwide average effective dose rate is about 1105 microSv a(-1). For 220Rn and its progeny, the corresponding value is 91 microSv a(-1). In both cases, the effective dose is mainly due to a particle irradiation of the bronchial tissues of the lungs. Overall, the worldwide average effective dose rate from natural background is about 2400 microSv a(-1) or 2.4 @entity2 a(-1). For comparison, worldwide average effective dose rates from weapons fallout peaked at 113 microSv a(-1) (about 5% of natural background) in 1963 and have since fallen to about 5.5 microSv a(-1) (about 0.2% of natural background). These values perhaps serve to emphasise that even gross insults to the natural environment from anthropogenic releases of radioactive materials are likely to be of limited significance when set in the context of the ambient radioactive environment within which all organisms, including @entity0 , have developed.

title: Background radiation: natural and XXXX -made.

answer: @entity0