abstract: @entity6 , a Gram-negative obligate anaerobic black-pigmented oral bacterium, belongs to a small group of microorganisms that is closely associated with the @entity5 . Lipopolysaccharide (LPS), an outer membrane component, is one of the main virulence factors of this bacterium. The aim of this study was to examine the effects of Prev. intermedia lipopolysaccharide, extracted by the hot- @entity7 -water method, on differentiation (alkaline phosphatase activity) and mineralisation ( @entity1 incorporation) of fetal @entity0 calvarial cells in vitro and to determine the release of the important osteolytic factors @entity3 , @entity2 ( @entity2 ) and matrix metalloproteinases by these cells after treatment with different concentrations of Prev. intermedia lipopolysaccharide (0.2-25 microg/ml). By gelatin zymography, we also characterized the matrix metalloproteinases released by these osteoblasts. Treatment with Prev. intermedia lipopolysaccharide dose-dependently inhibited bone formation by reducing alkaline phosphatase activity and @entity1 incorporation and induced the release of @entity3 , @entity2 and the latent proforms of @entity8 and @entity4 by fetal @entity0 osteoblasts in organoid culture. These results indicate that the lipopolysaccharide from Prev. intermedia not only participates in periodontal tissue destruction and alveolar bone resorption, but also inhibits bone formation.

title: Effects of lipopolysaccharide extracted from @entity6 on bone formation and on the release of osteolytic mediators by fetal XXXX osteoblasts in vitro.

answer: @entity0


abstract: The long-term prognosis of @entity9 and the factors influencing it were assessed in 217 consecutive @entity0 hospitalized in our coronary care unit and followed for a mean of 65 months (range 2 to 123). @entity1 occurred in 30 @entity0 and an additional 54 experienced a nonfatal @entity3 . Survival at 1 and 5 years was 95% and 89%, respectively; survival without @entity6 was 83% and 69%. @entity2 activity were strong predictors of survival by Cox analysis. Survival at 1 year was 99%, and that at 5 years was 95% and 94%, respectively, for @entity0 with one-vessel disease (n = 81) and for those without stenoses of 70% or greater (n = 87). Survival at 1 and 5 years was only 87% and 77% for those with multivessel disease (n = 40). The Cox analysis selected left ventricular function, initial treatment, extent score, duration of @entity5 at rest, and disease activity as multivariate predictors of survival without @entity6 . @entity2 was a strong predictor (p less than .0001) of survival without @entity6 by univariate analysis. Treatment with @entity4 , @entity8 , or @entity7 improved survival without @entity6 compared with other medical treatment (p = .002). @entity3 occurred most commonly soon after diagnosis in @entity0 with a short history of @entity5 at rest. Late coronary events were almost never preceded by resting @entity5 .

title: Long-term prognosis of @entity0 with XXXX .

answer: @entity9


abstract: The long-term prognosis of @entity9 and the factors influencing it were assessed in 217 consecutive @entity0 hospitalized in our coronary care unit and followed for a mean of 65 months (range 2 to 123). @entity1 occurred in 30 @entity0 and an additional 54 experienced a nonfatal @entity3 . Survival at 1 and 5 years was 95% and 89%, respectively; survival without @entity6 was 83% and 69%. @entity2 activity were strong predictors of survival by Cox analysis. Survival at 1 year was 99%, and that at 5 years was 95% and 94%, respectively, for @entity0 with one-vessel disease (n = 81) and for those without stenoses of 70% or greater (n = 87). Survival at 1 and 5 years was only 87% and 77% for those with multivessel disease (n = 40). The Cox analysis selected left ventricular function, initial treatment, extent score, duration of @entity5 at rest, and disease activity as multivariate predictors of survival without @entity6 . @entity2 was a strong predictor (p less than .0001) of survival without @entity6 by univariate analysis. Treatment with @entity4 , @entity8 , or @entity7 improved survival without @entity6 compared with other medical treatment (p = .002). @entity3 occurred most commonly soon after diagnosis in @entity0 with a short history of @entity5 at rest. Late coronary events were almost never preceded by resting @entity5 .

title: Long-term prognosis of XXXX with @entity9 .

answer: @entity0


abstract: BACKGROUND AND OBJECTIVE: @entity1 and @entity5 are major complications immediately after coronary artery bypass grafting. They may be due to incomplete surgical revascularization, perioperative anaesthetic management or @entity7 of arterial grafts, e.g. the internal mammary artery. Infusions of @entity3 or @entity8 have been advocated to prevent @entity6 of the mammary artery. The study compared the incidence of @entity1 after continuous infusion of either @entity3 (0.2 microg kg(-1) min(-1)) or @entity8 (0.375 microg kg(-1) min(-1)) in @entity0 with compromised left ventricular function scheduled for elective coronary artery bypass graft. METHODS: After Institutional Review Board approval, this double-blinded randomized clinical study enrolled 30 adult @entity0 with compromised left ventricular function (ejection fraction < 0.4) scheduled for elective coronary artery bypass grafting after written informed consent had been obtained. Ischaemia was detected by Holter electrocardiographic monitoring. The incidence of @entity1 death was monitored by serial determinations of the @entity4 kinase-MB (CK-MB) and troponin-I. RESULTS: New ST elevation > or = 0.2 mV or new ST @entity2 < or = 0.1 mV occurred in five of 15 @entity0 in the @entity8 group (33.3%) and in 13 of 15 @entity0 (86.6%) in the @entity3 group (P < 0.05). There were increases in CK-MB and troponin-I in both groups. Twenty-four hours postoperatively, CK-MB (P = 0.003) and troponin-I (P = 0.001) were significantly higher in the @entity3 group. CONCLUSIONS: Perioperative continuous infusion of @entity8 , compared with @entity3 , results in a significantly lower incidence of @entity1 and @entity1 damage after elective coronary artery bypass grafting.

title: XXXX in @entity0 with impaired left ventricular function undergoing coronary artery bypass grafting-- @entity8 versus nifedipin.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVE: @entity1 and @entity5 are major complications immediately after coronary artery bypass grafting. They may be due to incomplete surgical revascularization, perioperative anaesthetic management or @entity7 of arterial grafts, e.g. the internal mammary artery. Infusions of @entity3 or @entity8 have been advocated to prevent @entity6 of the mammary artery. The study compared the incidence of @entity1 after continuous infusion of either @entity3 (0.2 microg kg(-1) min(-1)) or @entity8 (0.375 microg kg(-1) min(-1)) in @entity0 with compromised left ventricular function scheduled for elective coronary artery bypass graft. METHODS: After Institutional Review Board approval, this double-blinded randomized clinical study enrolled 30 adult @entity0 with compromised left ventricular function (ejection fraction < 0.4) scheduled for elective coronary artery bypass grafting after written informed consent had been obtained. Ischaemia was detected by Holter electrocardiographic monitoring. The incidence of @entity1 death was monitored by serial determinations of the @entity4 kinase-MB (CK-MB) and troponin-I. RESULTS: New ST elevation > or = 0.2 mV or new ST @entity2 < or = 0.1 mV occurred in five of 15 @entity0 in the @entity8 group (33.3%) and in 13 of 15 @entity0 (86.6%) in the @entity3 group (P < 0.05). There were increases in CK-MB and troponin-I in both groups. Twenty-four hours postoperatively, CK-MB (P = 0.003) and troponin-I (P = 0.001) were significantly higher in the @entity3 group. CONCLUSIONS: Perioperative continuous infusion of @entity8 , compared with @entity3 , results in a significantly lower incidence of @entity1 and @entity1 damage after elective coronary artery bypass grafting.

title: @entity1 in @entity0 with impaired left ventricular function undergoing coronary artery bypass grafting-- XXXX versus nifedipin.

answer: @entity8


abstract: BACKGROUND AND OBJECTIVE: @entity1 and @entity5 are major complications immediately after coronary artery bypass grafting. They may be due to incomplete surgical revascularization, perioperative anaesthetic management or @entity7 of arterial grafts, e.g. the internal mammary artery. Infusions of @entity3 or @entity8 have been advocated to prevent @entity6 of the mammary artery. The study compared the incidence of @entity1 after continuous infusion of either @entity3 (0.2 microg kg(-1) min(-1)) or @entity8 (0.375 microg kg(-1) min(-1)) in @entity0 with compromised left ventricular function scheduled for elective coronary artery bypass graft. METHODS: After Institutional Review Board approval, this double-blinded randomized clinical study enrolled 30 adult @entity0 with compromised left ventricular function (ejection fraction < 0.4) scheduled for elective coronary artery bypass grafting after written informed consent had been obtained. Ischaemia was detected by Holter electrocardiographic monitoring. The incidence of @entity1 death was monitored by serial determinations of the @entity4 kinase-MB (CK-MB) and troponin-I. RESULTS: New ST elevation > or = 0.2 mV or new ST @entity2 < or = 0.1 mV occurred in five of 15 @entity0 in the @entity8 group (33.3%) and in 13 of 15 @entity0 (86.6%) in the @entity3 group (P < 0.05). There were increases in CK-MB and troponin-I in both groups. Twenty-four hours postoperatively, CK-MB (P = 0.003) and troponin-I (P = 0.001) were significantly higher in the @entity3 group. CONCLUSIONS: Perioperative continuous infusion of @entity8 , compared with @entity3 , results in a significantly lower incidence of @entity1 and @entity1 damage after elective coronary artery bypass grafting.

title: @entity1 in XXXX with impaired left ventricular function undergoing coronary artery bypass grafting-- @entity8 versus nifedipin.

answer: @entity0


abstract: During 1966 and 1986 202 @entity0 with @entity1 in the bone marrow biopsy were observed. All hairy cells were categorized according to their nuclear morphology into ovoid subtype, convoluted subtype and indented subtype. The overall survival of 113 non-splenectomised @entity0 was 11 months. However, the median survival time of each subtype differed considerably with 55 months for the ovoid subtype, 8 months for the convoluted and 6 months for the indented type. The prognosis of splenectomy @entity0 were significantly better at a p-value of less than 0.0001 than the survival of the non-splenectomised @entity0 . The median survival time was 59 months. Also in this group of @entity0 the prognosis was different for the ovoid, convoluted and indented subtype. The median survival time of the ovoid subtype is not yet reached, despite a observation time of more than 180 months. In contrast, the survival time for the convoluted and indented subtypes was 26 months. These data elucidate that at least part of the heterogeneity in the clinical course of this disease can be explained by the morphologically distinct subtypes and that splenectomy prolongs profoundly but to a different degree the survival of @entity0 with all three histological subtypes. The response rate to r.-IFN alpha-2b is higher in @entity0 with the ovoid than with the convoluted and indented subtypes.

title: [Diagnosis and prognosis of XXXX ].

answer: @entity1


abstract: @entity1 is an infrequent but life-threatening complication after cardiac operations. We reviewed our experience in treating eight select @entity0 in whom this complication developed. Diffuse @entity1 was verified at operation, and all @entity0 were treated with the same surgical procedure by the same surgeon. The technique consisted of sternal bone d  bridement, mediastinal fat and connective tissue excision, pericardiectomy, and transfer of the greater omentum into the mediastinum on a vascular pedicle for obliteration of dead space. The sternum and sternal fascia were closed completely and the skin was closed loosely in each case. Postoperative drainage was not provided and postoperative irrigation was not performed. The mortality rate was 12.5% and the hospital stay averaged 27 days, comparable to other series in which irrigation has been used. We conclude from this review that the approach of omental transfer provides an alternative to prolonged irrigation and drainage of the mediastinum in the surgical management of these critically ill @entity0 . This is neither a radical nor a disfiguring procedure, but is simple and easily done by the cardiac surgeon. Early ambulation, because of a lack of cumbersome irrigation and drainage apparatus, results in improved pulmonary function. Dead space is obliterated with tissue that has demonstrable ability to resist infection. Also, loose closure of the skin allows for primary healing with a good cosmetic result.

title: Poststernotomy XXXX treated by omental transfer without postoperative irrigation or drainage.

answer: @entity1


abstract: BACKGROUND: Studies of @entity6 @entity0 confirm that acceptance of @entity2 and values-based action are strong predictors of @entity2 and that interventions fostering " @entity3 " confer positive outcomes. However, data on these processes in @entity5 remain limited. This cross-sectional study examined relations between components of @entity3 and @entity1 among treatment-seeking migraineurs. METHODS: A total of 103 adults (M age   =   41.5 (11.9) years; 88.2% female) with ICHD-confirmed @entity5 (71.8% episodic, 28.2% chronic) across three clinics completed measures of @entity3 and @entity1 . Hierarchical regressions quantified relations between acceptance/values-based action and @entity1 variables after first controlling for @entity2 severity and gender. RESULTS: Acceptance of @entity2 and values-based action accounted for 10% of unique variance in @entity1 severity (  R(2) p   =   0.006) and up to 20% in @entity1 (  R(2) ps   =   0.02 and   <   0.001) but were weakly related to @entity1 frequency. Psychological flexibility was more strongly associated with MIDAS-measured disability than was @entity1 severity or @entity1 frequency. Significant effects were typically of medium-to-large size and driven primarily by values-based action. CONCLUSIONS: Paralleling results from the broader @entity4 literature, @entity2 acceptance and values-based action play significant roles in @entity2 and disability. Further study of interventions targeting these processes may enhance existing treatments.

title: Psychological flexibility in @entity5 : A study of XXXX acceptance and values-based action.

answer: @entity2


abstract: BACKGROUND: Studies of @entity6 @entity0 confirm that acceptance of @entity2 and values-based action are strong predictors of @entity2 and that interventions fostering " @entity3 " confer positive outcomes. However, data on these processes in @entity5 remain limited. This cross-sectional study examined relations between components of @entity3 and @entity1 among treatment-seeking migraineurs. METHODS: A total of 103 adults (M age   =   41.5 (11.9) years; 88.2% female) with ICHD-confirmed @entity5 (71.8% episodic, 28.2% chronic) across three clinics completed measures of @entity3 and @entity1 . Hierarchical regressions quantified relations between acceptance/values-based action and @entity1 variables after first controlling for @entity2 severity and gender. RESULTS: Acceptance of @entity2 and values-based action accounted for 10% of unique variance in @entity1 severity (  R(2) p   =   0.006) and up to 20% in @entity1 (  R(2) ps   =   0.02 and   <   0.001) but were weakly related to @entity1 frequency. Psychological flexibility was more strongly associated with MIDAS-measured disability than was @entity1 severity or @entity1 frequency. Significant effects were typically of medium-to-large size and driven primarily by values-based action. CONCLUSIONS: Paralleling results from the broader @entity4 literature, @entity2 acceptance and values-based action play significant roles in @entity2 and disability. Further study of interventions targeting these processes may enhance existing treatments.

title: Psychological flexibility in XXXX : A study of @entity2 acceptance and values-based action.

answer: @entity5


abstract: To evaluate pattern of using of three antifungal drugs: @entity3 , @entity2 and @entity4 , at the hematology-oncology and bone marrow transplant wards of one large teaching hospital. In a prospective cross-sectional study, we evaluated the appropriateness of using antifungal drugs in @entity0 , using Infectious Disease Society of America (IDSA) and National @entity1 Network (NCCN) guidelines. All the data were recorded daily by a pharmacist in a form designed by a clinical pharmacist and infectious diseases specialist, for antifungals usage, administration, and monitoring. During the study, 116 @entity0 were enrolled. Indications of prescribing @entity2 , @entity3 , and @entity4 were appropriate according to guidelines in 83.4%, 80.6%, and 76.9% respectively. The duration of treatments were appropriate according to guidelines in 75%, 64.5%, and 71.1% respectively. The dose of @entity4 was appropriate according to guidelines in 46.2% of @entity0 . None of the @entity0 received salt loading before administration of @entity2 . The most considerable problems with the mentioned antifungals were about the indications and duration of treatment. In addition, prehydration for @entity2 and dosage of @entity4 were not completely compatible with the mentioned guidelines. A suitable combination of controlling the use of antifungals and educational programs could be essential for improving the general process of using antifungal drugs at our hospital.

title: Antifungal agent utilization evaluation in hospitalized neutropenic XXXX @entity0 at a large teaching hospital.

answer: @entity1


abstract: To evaluate pattern of using of three antifungal drugs: @entity3 , @entity2 and @entity4 , at the hematology-oncology and bone marrow transplant wards of one large teaching hospital. In a prospective cross-sectional study, we evaluated the appropriateness of using antifungal drugs in @entity0 , using Infectious Disease Society of America (IDSA) and National @entity1 Network (NCCN) guidelines. All the data were recorded daily by a pharmacist in a form designed by a clinical pharmacist and infectious diseases specialist, for antifungals usage, administration, and monitoring. During the study, 116 @entity0 were enrolled. Indications of prescribing @entity2 , @entity3 , and @entity4 were appropriate according to guidelines in 83.4%, 80.6%, and 76.9% respectively. The duration of treatments were appropriate according to guidelines in 75%, 64.5%, and 71.1% respectively. The dose of @entity4 was appropriate according to guidelines in 46.2% of @entity0 . None of the @entity0 received salt loading before administration of @entity2 . The most considerable problems with the mentioned antifungals were about the indications and duration of treatment. In addition, prehydration for @entity2 and dosage of @entity4 were not completely compatible with the mentioned guidelines. A suitable combination of controlling the use of antifungals and educational programs could be essential for improving the general process of using antifungal drugs at our hospital.

title: Antifungal agent utilization evaluation in hospitalized neutropenic @entity1 XXXX at a large teaching hospital.

answer: @entity0


abstract: PRIMARY OBJECTIVES: To follow-up a population of @entity0 admitted to one Hospital Trust with @entity2 ( @entity2 ), and compare outcomes following mild @entity2 with outcomes following moderate or severe @entity2 . RESEARCH DESIGN: Population-based postal questionnaire survey. METHODS AND PROCEDURES: Questionnaires were mailed to parents of all 974 surviving @entity0 on a register of paediatric @entity2 admissions, 525 completed questionnaires were returned (56.2%). Most @entity0 (419) had suffered mild @entity2 , 57 moderate, and 49 severe. MAIN OUTCOMES AND RESULTS: Thirty per cent of parents received no information on @entity1 symptoms, and clinical follow-up was limited. Statistically significant differences were observed between mild and moderate/severe groups for cognitive, social, emotional, and mobility problems. Nevertheless, approximately 20% of the mild group suffered from poor concentration, personality change and educational problems @entity1 . Few schools (20%) made special provision for @entity0 returning after injury. CONCLUSIONS: @entity0 can have long-lasting and wide-ranging sequelae following @entity2 . Information should be routinely given to parents and schools after @entity3 .

title: @entity0 's XXXX : a postal follow-up of 525 @entity0 from one health region in the UK.

answer: @entity3


abstract: PRIMARY OBJECTIVES: To follow-up a population of @entity0 admitted to one Hospital Trust with @entity2 ( @entity2 ), and compare outcomes following mild @entity2 with outcomes following moderate or severe @entity2 . RESEARCH DESIGN: Population-based postal questionnaire survey. METHODS AND PROCEDURES: Questionnaires were mailed to parents of all 974 surviving @entity0 on a register of paediatric @entity2 admissions, 525 completed questionnaires were returned (56.2%). Most @entity0 (419) had suffered mild @entity2 , 57 moderate, and 49 severe. MAIN OUTCOMES AND RESULTS: Thirty per cent of parents received no information on @entity1 symptoms, and clinical follow-up was limited. Statistically significant differences were observed between mild and moderate/severe groups for cognitive, social, emotional, and mobility problems. Nevertheless, approximately 20% of the mild group suffered from poor concentration, personality change and educational problems @entity1 . Few schools (20%) made special provision for @entity0 returning after injury. CONCLUSIONS: @entity0 can have long-lasting and wide-ranging sequelae following @entity2 . Information should be routinely given to parents and schools after @entity3 .

title: XXXX 's @entity3 : a postal follow-up of 525 @entity0 from one health region in the UK.

answer: @entity0


abstract: PRIMARY OBJECTIVES: To follow-up a population of @entity0 admitted to one Hospital Trust with @entity2 ( @entity2 ), and compare outcomes following mild @entity2 with outcomes following moderate or severe @entity2 . RESEARCH DESIGN: Population-based postal questionnaire survey. METHODS AND PROCEDURES: Questionnaires were mailed to parents of all 974 surviving @entity0 on a register of paediatric @entity2 admissions, 525 completed questionnaires were returned (56.2%). Most @entity0 (419) had suffered mild @entity2 , 57 moderate, and 49 severe. MAIN OUTCOMES AND RESULTS: Thirty per cent of parents received no information on @entity1 symptoms, and clinical follow-up was limited. Statistically significant differences were observed between mild and moderate/severe groups for cognitive, social, emotional, and mobility problems. Nevertheless, approximately 20% of the mild group suffered from poor concentration, personality change and educational problems @entity1 . Few schools (20%) made special provision for @entity0 returning after injury. CONCLUSIONS: @entity0 can have long-lasting and wide-ranging sequelae following @entity2 . Information should be routinely given to parents and schools after @entity3 .

title: @entity0 's @entity3 : a postal follow-up of 525 XXXX from one health region in the UK.

answer: @entity0


abstract: OBJECTIVE: To probe into effective surgical procedures and improve the outcome of treatment for @entity0 with severe @entity1 . METHODS: A retrospective study involving 113 @entity0 with severe @entity1 (AAST grade IV and V) during the past 12 years was carried out. Ninety-eight @entity0 underwent surgical treatment. Surgical interventions including hepatectomy or direct control of bleeding vessels by finger fracture technique with Pringle maneuver, selective ligation of hepatic artery, retrohepatic caval repair with total @entity1 , and perihepatic packing were mainly used. RESULTS: In the 98 @entity0 treated operatively, the survival rate was 69.4% (68/98). Among 40 @entity0 with @entity4 ( @entity4 ), 15 were cured with the maximum blood transfusion of 12,000 ml. Eight cases of Grade IV injury treated nonoperatively were cured. The percentage of failure of nonoperative management was 42.9% (6/14). The overall mortality rate was 32.7% (37/113), and 57% of the @entity3 were due to exsanguination. CONCLUSIONS: Reasonable surgical procedures based on classification of hepatic injuries can increase the survival rate of severe liver @entity2 . Accurate perihepatic packing is effective in dealing with @entity4 .

title: Severe XXXX : surgical strategies.

answer: @entity1


abstract: OBJECTIVE: To discuss the mechanism of @entity5 caused by concussion and the effect of @entity7 on concussion. METHODS: A total of 224 @entity0 who were treated from March 1995 to October 1999 were divided into two groups randomly, ie, @entity7 group (113 cases) and control group (111 cases). @entity4 (BA) and the average peak forward velocity of cerebral blood flow were observed by color three-dimensional transcranial Doppler (3D- @entity8 ) within 24 hours after admission and at the end of 3-6 days of treatment. Cerebral blood flow changes, characteristics and treatment effect were analyzed and determined by clinical main symptom disappearance rate. RESULTS: In concussion, cerebral blood flow was divided into 3 phases: cerebral blood flow low infusion dilation phase, cerebral @entity6 phase and cerebral blood flow recovery phase. In the @entity7 group, clinical main symptom disappearance rate was higher than that in the control group in the cerebral spasm and recovery phases with a significant difference (P < 0.01). CONCLUSIONS: @entity5 , @entity3 and @entity1 lesion are the main pathological changes. Whether @entity2 is reversible or not is mainly determined by spasm time of cerebral blood vessel. @entity7 has a good effect on releasing spasm and diminishing the cerebral blood flow velocity. It not only improves curative effect on concussion, but also reduces and prevents concussion sequelae. Hence, concussion @entity0 who have cerebral spasm confirmed by 3D- @entity8 should be given @entity7 routinely and early.

title: Mechanism and treatment principle for XXXX caused by concussion.

answer: @entity5


abstract: Objectives. This study compared the macular and retinal nerve fibre layer (RNFL) thicknesses and optic nerves of eyes with @entity0 due to @entity3 with the contralateral healthy eyes in adults using optical coherence tomography (OCT). Methods. This cross-sectional study was conducted in Atat  rk State Hospital, Sinop, @entity1 . Macular and RNFL thicknesses, optic nerve disc area, cup area, and horizontal and vertical cup-to-disc ratios obtained using a NIDEK RS-3000 SLO spectral domain OCT device were compared between the amblyopic and fellow eyes in 30 adults with @entity2 18-55 years old who were seen in our clinic with @entity0 . Results. The mean macular thickness was 266.90    23.22     m in the amblyopic eyes and 263.90    22.84     m in the fellow eyes, and the mean RNFL thickness was 111.90    12.9 and 109.70    9.42     m, respectively. The two thicknesses did not differ significantly between the amblyopic and fellow eyes. There were also no significant differences between the eyes in disc area, cup area, and horizontal-vertical cup/disc ratios. Conclusion. There does not seem to be a difference in macular thickness, peripapillary RNFL, or optic disc structures between the amblyopic and fellow eyes in adults.

title: Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic XXXX .

answer: @entity2


abstract: @entity4 can be complicated by a traumatic durotomy that may lead to the rare development of a retropharyngeal pseudomeningocele. To our knowledge this has been reported only five times previously. We present the case of a 60-year-old @entity0 involved in a motor vehicle accident who suffered an @entity4 and @entity3 . A unique MRI image of a defect in the ventral dura posterior to C2 was appreciated. He underwent occiput to T2 internal fixation and arthrodesis. During surgery, CSF egress was seen caudal to the right C2 nerve root. A DuraMatrix onlay patch reinforced with DuraSeal was placed to stop the CSF leak. A lumbar subarachnoid drain was also placed. The @entity0 made a satisfactory recovery with residual mild @entity2 of his right upper extremity. In this report, we demonstrate that careful MRI review can reveal a ventral durotomy in a @entity1 and, if discovered, effective treatment including a lumbar subarachnoid drain for CSF diversion may prevent progression to a retropharyngeal pseudomeningocele. The literature on this rare presentation and associated durotomy is provided.

title: Early Identification of XXXX Associated with @entity4 May Prevent Retropharyngeal Pseudomeningocele Development.

answer: @entity1


abstract: @entity4 can be complicated by a traumatic durotomy that may lead to the rare development of a retropharyngeal pseudomeningocele. To our knowledge this has been reported only five times previously. We present the case of a 60-year-old @entity0 involved in a motor vehicle accident who suffered an @entity4 and @entity3 . A unique MRI image of a defect in the ventral dura posterior to C2 was appreciated. He underwent occiput to T2 internal fixation and arthrodesis. During surgery, CSF egress was seen caudal to the right C2 nerve root. A DuraMatrix onlay patch reinforced with DuraSeal was placed to stop the CSF leak. A lumbar subarachnoid drain was also placed. The @entity0 made a satisfactory recovery with residual mild @entity2 of his right upper extremity. In this report, we demonstrate that careful MRI review can reveal a ventral durotomy in a @entity1 and, if discovered, effective treatment including a lumbar subarachnoid drain for CSF diversion may prevent progression to a retropharyngeal pseudomeningocele. The literature on this rare presentation and associated durotomy is provided.

title: Early Identification of @entity1 Associated with XXXX May Prevent Retropharyngeal Pseudomeningocele Development.

answer: @entity4


abstract: @entity14 production by the pineal gland in the vertebrate brain has attracted much scientific attention. Pineal @entity14 is regulated by photoperiodicity, whereas circadian secretion of @entity14 produced in the gastrointestinal tract is regulated by food intake. Thus, the circadian rhythm of pineal @entity14 depends upon whether a species is diurnal or nocturnal. @entity12 ( @entity12 ) involves damage to the spinal cord caused by @entity4 or disease that results in compromise or loss of body function. @entity14 is the most efficient and commonly used pharmacological antioxidant treatment for @entity12 . @entity14 is an @entity15 secreted by the pineal gland during the dark phase of the circadian cycle. Neurorehabilitation is a complex medical process that focuses on improving function and repairing damaged connections in the brain and nervous system following injury. Physical activity associated with an active lifestyle reduces the risk of @entity2 , @entity3 , @entity5 2 @entity0 , @entity6 , and @entity9 and protects against @entity1 , including @entity7 , @entity8 , and @entity10 . Physical activity has been shown to increase the gene expression of several brain neurotrophins ( @entity13 [ @entity13 ], nerve growth factor, and galanin) and the production of mitochondrial uncoupling protein 2, which promotes neuronal survival, differentiation, and growth. In summary, @entity14 is a neural protectant, and when combined with therapeutic exercise, the hormone prevents the progression of secondary @entity11 in @entity12 . The present review briefly describes the pathophysiological mechanisms underlying @entity12 , focusing on therapeutic targets and combined @entity14 and exercise therapy, which can attenuate secondary injury mechanisms with minimal side effects.

title: New Prophylactic and Therapeutic Strategies for XXXX .

answer: @entity12


abstract: Objectives. To evaluate the differences in prognostic values of static and dynamic PET-CT in @entity2 ( @entity2 ). Material and Methods. Forty-five @entity0 who had static scan were recruited. Sixteen had dynamic scan. The primary lesions were delineated from standardized uptake value (SUV) maps from static scan and K i maps from dynamic scan. The average follow-up lasted for 34 months. The @entity0 who died or those with recurrence/residual disease were considered "poor outcome"; otherwise they were considered "good outcome." Fisher's exact test and ROC analysis were used to evaluate the prognostic value of various factors. Results. @entity1 volume thresholded by 40% of maximal SUV (VOLSUV40) significantly predicted treatment outcome (p = 0.024) in the whole cohort. In 16 @entity0 with dynamic scan, all parameters by dynamic scan were insignificant in predicting the outcome. The combination of maximal SUV, maximal K i , VOLSUV40, and VOL K i 37 (the @entity1 volume thresholded by 37% maximal K i ) achieved the highest predicting accuracy for treatment outcome with sensitivity, specificity, and accuracy of 100% in these 16 @entity0 ; however this improvement compared to VOLSUV40 was insignificant. Conclusion. @entity1 volume from static scan is useful in @entity2 prognosis. However, the role of dynamic scanning was not justified in this small cohort.

title: Prognostic Value of (18) F-FDG PET-CT in XXXX : Is Dynamic Scanning Helpful?

answer: @entity2


abstract: PURPOSE: Craniofacial @entity2 is a @entity1 in which normal craniofacial bones are replaced by immature fibro-osseous tissue. Orbital involvement may present as @entity3 in some @entity0 . The etiology of @entity3 in @entity4 is still unclear, with many theories proposed in recent literature. This has led to developments in the controversy regarding the role of prophylactic optic nerve decompression in asymptomatic @entity4 @entity0 . This case report and literature review evaluates the need for early surgical intervention in such @entity0 , as well as highlights other aspects of the condition and its management. DESIGN: Case report and literature review. METHODS: This was a case report of a 12-year-old Chinese @entity0 who developed progressive @entity3 in association with craniofacial @entity2 involving the orbit. Literature regarding the epidemiology, pathophysiology, clinical features, diagnosis, investigations, and management was searched from the PubMed database. RESULTS: Extradural decompression of the optic nerve resulted in marked visual improvement, with temporal optic atrophy noted postoperatively. Literature review revealed a number of recent studies recommending against prophylactic optic nerve decompression, but early surgical intervention upon onset of @entity3 is suggested. CONCLUSIONS: Immediate surgical referral and early optic nerve decompression is recommended upon onset of @entity3 . Periodic follow-up is recommended to monitor for recurrence and malignant transformation.

title: Craniofacial XXXX Involving the Orbit: A Case Report and Literature Review.

answer: @entity2


abstract: PURPOSE: To determine the mean @entity4 ( @entity4 ) and the relationship between the @entity4 and @entity1 in primary angle closure (PAC) and primary @entity3 (PACG). DESIGN: A combined cross-sectional and prospective study on PAC and PACG. METHODS: A total of 35 eyes were included in the study for each group of normal control, PAC, and PACG @entity0 from eye clinics in Kota Bharu, state of Kelantan, Malaysia, from January 2007 to November 2009. The PAC and PACG @entity0 were divided into thin and thick @entity4 groups. They were followed up for 12 to 18 months for @entity1 assessment with their mean @entity2 Intervention Study (AGIS) score. RESULTS: The @entity4 was 516.8    26.0   m for PAC and 509.7    27.4   m for PACG. Both were significantly thinner compared with the control group with @entity4 of 540    27.8   m (P < 0.001). There was a statistically significant increase in the mean AGIS score after 12.9    1.7 months of follow-up in the thin @entity4 group for PACG (P = 0.002). However, no significant increase in the mean AGIS score was found for the thick @entity4 group in PACG and for both thin and thick @entity4 in PAC. CONCLUSIONS: The PAC and PACG had statistically significant thinner @entity4 compared with the controls. Thin @entity4 was associated with @entity1 based on the mean AGIS score in PACG.

title: A Study on the Central Corneal Thickness of Primary Angle Closure and XXXX and Its Effect on Visual Field Progression.

answer: @entity3


abstract: BACKGROUND CONTEXT: Although the types and incidence of adverse events (AEs) associated with transforaminal epidural @entity5 injection (TFESI) have been described, no study has used a systematic standardized questionnaire to solicit AEs from @entity0 to capture an accurate range and incidence of complications. PURPOSE: The aim was to systematically identify the types and incidence of AEs associated with TFESI. Additionally, this study evaluated demographic and clinical factors that may predict a higher risk of an AE. STUDY DESIGN/SETTING: This was a retrospective cohort study from a multiphysician academic PM_R clinic. @entity0 SAMPLE: @entity0 , aged 19 to 89, who underwent a fluoroscopically guided TFESI for @entity7 @entity3 between 2004 and 2007 were included. OUTCOME MEASURES: The relationship of AEs with gender, age, trainee presence, @entity5 type, preprocedure visual analog scale (VAS) @entity3 score, systolic blood pressure, fluoroscopy time, and @entity4 injectate volume was analyzed. METHODS: Adverse event data were collected using a survey both immediately and at 24 to 72 hours after TFESI. Statistical analysis was performed using the chi-square, Fisher exact, or Wilcoxon rank sum two-sided tests. Logistic regression analysis was also performed. C.P. is the owner of Rehabilitation Institute of Chicago Physiatric Log _ Analysis System computer software. RESULTS: In 1,295 consecutive @entity0 undergoing 2,025 TFESI procedures, immediate AEs and delayed AEs occurred after 182 (9.2%) and 305 (20.0%) injections, respectively. The most common immediate AEs were: vasovagal reaction (4.2%) and interrupted procedure from intravascular flow (1.7%). Common delayed AEs included: @entity3 exacerbation (5.0%), injection site soreness (3.9%), @entity1 (3.9%), @entity6 (1.8%), and @entity2 (1.6%). Significant associations were identified between AEs and gender, age, preprocedure VAS, @entity5 type, and fluoroscopy time. Trainee involvement in the procedure did not impact the complication rate. CONCLUSIONS: Fluoroscopically guided lumbosacral TFESI is associated with a similar rate of minor AEs both immediately and 24 to 72 hours after procedure that are typical of other axial @entity4 injections. Permanent AEs were not found in this sample. The most common AEs associated with TFESI include vasovagal episodes, procedure interruption from intravascular flow, @entity3 exacerbation, injection site soreness, @entity1 , and @entity2 .

title: Adverse events associated with fluoroscopically guided lumbosacral transforaminal epidural XXXX injections.

answer: @entity5


abstract: @entity9 is an @entity7 disease. It is characterized by an increase in IgE and eosinophil count with both T-cell and B-cell malfunction. Here, we report an 8-year-old @entity0 whose disease started with an unusual skin manifestation. When 6 months old he developed generalized red, nontender nodules and pathologic report of the @entity3 was unremarkable (inflammatory). Then he developed a painless, @entity6 . At the age of 4 years, he developed a seronegative @entity5 . Another skin biopsy was taken which was in favor of @entity8 . Laboratory workup for @entity7 showed high eosinophil count and high level of immunoglobulin-E, due to some diagnostic criteria (NIH sores: 41 in 9-year-olds), he was suggestive of @entity9 . At the age of 8, the @entity0 developed an abscess in the left inguinal region. While in hospital, the @entity0 developed generalized tonic colonic @entity4 and @entity2 . Brain computed tomography scan revealed an abscess in the right frontal lobe. Subsequently magnetic resonance imaging (MRI) of the brain indicated expansion of the existing @entity1 (left side). After evacuating the abscesses and administrating intravenous antibiotic, the @entity0 's condition improved dramatically and @entity2 stopped.

title: Brain Abscess and XXXX Suggestive of @entity9 .

answer: @entity8


abstract: @entity9 is an @entity7 disease. It is characterized by an increase in IgE and eosinophil count with both T-cell and B-cell malfunction. Here, we report an 8-year-old @entity0 whose disease started with an unusual skin manifestation. When 6 months old he developed generalized red, nontender nodules and pathologic report of the @entity3 was unremarkable (inflammatory). Then he developed a painless, @entity6 . At the age of 4 years, he developed a seronegative @entity5 . Another skin biopsy was taken which was in favor of @entity8 . Laboratory workup for @entity7 showed high eosinophil count and high level of immunoglobulin-E, due to some diagnostic criteria (NIH sores: 41 in 9-year-olds), he was suggestive of @entity9 . At the age of 8, the @entity0 developed an abscess in the left inguinal region. While in hospital, the @entity0 developed generalized tonic colonic @entity4 and @entity2 . Brain computed tomography scan revealed an abscess in the right frontal lobe. Subsequently magnetic resonance imaging (MRI) of the brain indicated expansion of the existing @entity1 (left side). After evacuating the abscesses and administrating intravenous antibiotic, the @entity0 's condition improved dramatically and @entity2 stopped.

title: Brain Abscess and @entity8 Suggestive of XXXX .

answer: @entity9


abstract: BACKGROUND: ' @entity2 ' also known as swimmers itch ( @entity1 ) is caused by a @entity3 parasite, Schistosoma which has two hosts - an invertebrate (snail) and a vertebrate (livestock, @entity0 being). Although the availability of both vector snails and pathogens at the selected site the Doon Valley in northern India has already been confirmed but there was a hazy picture of the disease, whether it is due to entrance of cercariae or due to wild variety of grass (Parthenium hysterophorus). The present study is an attempt to provide a way forward towards the vector snails and snail borne diseases in the study area. METHODS: Snail sampling and identification was done by applying standard methods / using Keys _ Catalogues. Associated parasites and cercariometry in snails has been worked out by cercarial shedding. @entity0 involvement at zo-onotic level has been performed in collaboration with Health centers and socio- economic aspect of inhabitants of study area. RESULTS: The snail diversity encountered 19 species including the vector species such as Indoplanorbis exustus, Gyraulus convexiusculus, Melanoides tuberculata and Lymnaea acuminata. The cercarial diversity comprised Furcocercous, Monostome, Amphistome and @entity4 / Xiphidiocercaria. During the study (2009-2010), 0.173% was found with @entity2 among @entity0 population in the selected area. The symptoms of disease recorded were red spots and swellings on effected parts of skin. Frequent visits of livestock to the water body and presence of vector snails provides a clue in completing the life cycle of the parasite of the family Schistosomatidae. CONCLUSION: @entity2 has been considered a potential risk at those places where warm blooded and snail's hosts share a link with aquatic bodies with particular emphasis to temperature and time of year.

title: Occurrence of a Snail Borne Disease, XXXX (Swimmer Itch) in Doon Valley (Uttarakhand), India.

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity7 ) is one of the most important pesticides which is extensively used to control weeds in arable farmland. Exposure to this compound occurs in general population and @entity0 who occupationally handle it. The aim of this present work was the preparation of @entity7 imprinting polymer and its application as a selective sample preparation technique for trace determination of @entity7 in biological and environmental samples. METHODS: In this study, @entity7 imprinting polymer was obtained by precipitation polymerization using @entity4 (the functional monomer), @entity8 (the cross-linker), @entity9 (the initiator) and @entity7 (the template molecule) in @entity3 solution. The MIP-NPs were characterized by thermogravimetric analysis and scanning electron microscopy. The optimization process was carried out applying batch method. After optimization of the parameters, affecting the adsorption and desorption of analyte, urine and different water samples were used to determine @entity7 . RESULTS: Imprinted @entity7 molecules were removed from the polymeric structure using @entity2 in @entity1 (20:80 v/v %) as the eluting solvent. Both sorption and desorption process occur within 10 min. The maximum sorbent capacity of the molecular imprinted polymer is 87.4 mg g-1. The relative standard deviation and limit of detection for water samples by introduced selective solid phase extraction were 4.8% and 0.9  g @entity6 , and these data for urine samples were 4.5% and 1.60  g @entity6 , respectively. CONCLUSION: The developed method was successfully applied to determine @entity7 in urine and different water samples.

title: Coupling of Molecular Imprinted Polymer Nanoparticles by High Performance Liquid Chromatography as an Efficient Technique for Sensitive and Selective Trace Determination of XXXX in Complex Matrices.

answer: @entity5


abstract: BACKGROUND AND PURPOSE: Advantages of new oral anticoagulations may be greater in @entity2 ( @entity2 ) @entity0 of poor anticoagulation control with @entity3 . The SAMe-TT2R2 scoring system, based on clinical variables, was recently developed to aid in identifying these @entity0 . In this study, we investigated the association of this clinical composite score with genetic factors related @entity3 dosing and the quality of anticoagulation control. METHODS: Clinical and genetic data were collected from 380 consecutive Korean @entity0 with @entity2 (CHA2DS2-VASc score, 3.5  1.8) who were followed for an average of 4 years. We evaluated factors associated with time in therapeutic range (TTR, INR 2-3), including the @entity6 and @entity5 genotypes and the SAMe-TT2R2 score (Sex female, Age <60 years, Medical history [>two co-morbidities], Treatment [interacting drugs, e.g., @entity4 ], @entity1 use within 2 years [doubled], and Race non-white [doubled]). RESULTS: The average SAMe-TT2R2 score was 3.4  0.9, range 2-7; and 153 @entity0 (40.2%) had SAMe-TT2R2 scores >= 4. Time in specific INR ranges varied depending on the @entity5 genotype but not with the @entity6 genotype or the SAMe-TT2R2 score. TTR was higher in @entity0 with the @entity5 @entity7 than in @entity5 TT (61.7  16% vs. 56.7  17.4%, P=0.031). Multivariate testing showed that @entity5 genotype but not the SAMe-TT2R2 score was significantly associated with labile INRs. There was no correlation between the SAMe-TT2R2 scores and pharmacogenetic data. CONCLUSIONS: A genetic factor, but none of the common clinical and demographic factors, as combined in the SAMe-TT2R2 score, was associated with the quality of anticoagulation control in Korean @entity0 with @entity2 .

title: Lack of Association of Clinical Factors (SAMe-TT2R2) with @entity6 / XXXX Genotype and Anticoagulation Control Quality.

answer: @entity5


abstract: BACKGROUND AND PURPOSE: Advantages of new oral anticoagulations may be greater in @entity2 ( @entity2 ) @entity0 of poor anticoagulation control with @entity3 . The SAMe-TT2R2 scoring system, based on clinical variables, was recently developed to aid in identifying these @entity0 . In this study, we investigated the association of this clinical composite score with genetic factors related @entity3 dosing and the quality of anticoagulation control. METHODS: Clinical and genetic data were collected from 380 consecutive Korean @entity0 with @entity2 (CHA2DS2-VASc score, 3.5  1.8) who were followed for an average of 4 years. We evaluated factors associated with time in therapeutic range (TTR, INR 2-3), including the @entity6 and @entity5 genotypes and the SAMe-TT2R2 score (Sex female, Age <60 years, Medical history [>two co-morbidities], Treatment [interacting drugs, e.g., @entity4 ], @entity1 use within 2 years [doubled], and Race non-white [doubled]). RESULTS: The average SAMe-TT2R2 score was 3.4  0.9, range 2-7; and 153 @entity0 (40.2%) had SAMe-TT2R2 scores >= 4. Time in specific INR ranges varied depending on the @entity5 genotype but not with the @entity6 genotype or the SAMe-TT2R2 score. TTR was higher in @entity0 with the @entity5 @entity7 than in @entity5 TT (61.7  16% vs. 56.7  17.4%, P=0.031). Multivariate testing showed that @entity5 genotype but not the SAMe-TT2R2 score was significantly associated with labile INRs. There was no correlation between the SAMe-TT2R2 scores and pharmacogenetic data. CONCLUSIONS: A genetic factor, but none of the common clinical and demographic factors, as combined in the SAMe-TT2R2 score, was associated with the quality of anticoagulation control in Korean @entity0 with @entity2 .

title: Lack of Association of Clinical Factors (SAMe-TT2R2) with XXXX / @entity5 Genotype and Anticoagulation Control Quality.

answer: @entity6


abstract: IMPORTANCE: @entity3 ( @entity3 ) is an important complication of colorectal surgery, but its incidence is unclear in the era of @entity3 prophylaxis. OBJECTIVE: To describe the incidence of and risk factors associated with @entity2 complications and contemporary @entity3 prophylaxis patterns following colorectal surgery. DESIGN, SETTING, AND @entity0 : Prospective data from the Washington State Surgical Care and Outcomes Assessment Program (SCOAP) linked to a statewide hospital discharge database. At 52 Washington State SCOAP hospitals, @entity0 included consecutive @entity0 undergoing colorectal surgery between January 1, 2006, and December 31, 2011. MAIN OUTCOMES AND MEASURES: @entity3 complications in-hospital and up to 90 days after surgery. RESULTS: Among 16   120 @entity0 (mean age, 61.4 years; 54.5% female), the use of perioperative and in-hospital @entity3 chemoprophylaxis increased significantly from 31.6% to 86.4% and from 59.6% to 91.4%, respectively, by 2011 (P   <   .001 for trend for both). Overall, 10.6% (1399 of 13   230) were discharged on a chemoprophylaxis regimen. The incidence of @entity3 was 2.2% (360 of 16   120). @entity0 undergoing abdominal operations had higher rates of 90-day @entity3 compared with @entity0 having pelvic operations (2.5% [246 of 9702] vs 1.8% [114 of 6413], P   =   .001). Those having an operation for @entity1 had a similar incidence of 90-day @entity3 compared with those having an operation for nonmalignant processes (2.1% [128 of 6213] vs 2.3% [232 of 9902], P   =   .24). On adjusted analysis, older age, nonelective surgery, history of @entity3 , and operations for inflammatory disease were associated with increased risk of 90-day @entity3 (P   <   .05 for all). There was no significant decrease in @entity3 over time. CONCLUSIONS AND RELEVANCE: @entity3 rates are low and largely unchanged despite increases in perioperative and postoperative prophylaxis. These data should be considered in developing future guidelines.

title: XXXX Complications and Prophylaxis Patterns in Colorectal Surgery.

answer: @entity2


abstract: BACKGROUND: Abuse or unintended @entity3 ( @entity3 ) of opiates and @entity5 may result in prehospital and @entity2 ( @entity2 ) care. Prehospital @entity4 use has been suggested as a surrogate marker of community opiate ODs. The study objective was to verify externally whether prehospital @entity4 use is a surrogate marker of community opiate ODs by comparing Emergency Medical Services (EMS) @entity4 administration records to an independent database of @entity2 visits for opiate and @entity5 ODs in the same community. METHODS: A retrospective chart review of prehospital and @entity2 data from July 2009 through June 2013 was conducted. Prehospital @entity4 administration data obtained from the electronic medical records (EMRs) of a large private EMS provider serving a metropolitan area were considered a surrogate marker for suspected opiate @entity3 . Comparison data were obtained from the regional @entity1 /psychiatric @entity2 that receives the majority of the @entity3 @entity0 . The @entity2 maintains a de-identified database of @entity6 for surveillance of narcotic use in the metropolitan area. The @entity2 database was queried for ODs associated with opiates or @entity5 . Cross-correlation analysis was used to test if prehospital @entity4 administration was independent of @entity2 visits for opiate/ @entity5 ODs. RESULTS: @entity4 was administered during 1,812 prehospital @entity0 encounters, and 1,294 @entity2 visits for opiate/ @entity5 ODs were identified. The distribution of @entity0 in the prehospital and @entity2 datasets did not differ by gender, but it did differ by race and age. The frequency of @entity4 administration by prehospital providers varied directly with the frequency of @entity2 visits for opiate/ @entity5 ODs. A monthly increase of two @entity2 visits for opiate-related ODs was associated with an increase in one prehospital @entity4 administration (cross-correlation coefficient [CCF]=0.44; P=.0021). A monthly increase of 100 @entity2 visits for @entity5 -related ODs was associated with an increase in 94 prehospital @entity4 administrations (CCF=0.46; P=.0012). CONCLUSIONS: Frequency of @entity4 administration by EMS providers in the prehospital setting varied directly with frequency of opiate/ @entity5 @entity3 -related @entity2 visits. The data correlated both for short-term frequency and longer term trends of use. However, there was a marked difference in demographic data suggesting neither data source alone should be relied upon to determine which populations are at risk within the community. Lindstrom HA , Clemency BM , Snyder R , Consiglio JD , May PR , Moscati RM . Prehospital @entity4 administration as a public health surveillance tool: a retrospective validation study. Prehosp Disaster Med. 2015;30(4):1-5.

title: Prehospital XXXX Administration as a Public Health Surveillance Tool: A Retrospective Validation Study.

answer: @entity4


abstract: UNASSIGNED: Within the circulation, @entity1 is transported by lipoprotein particles and is taken up by cells when these particles associate with cellular receptors. In macrophages, excessive lipoprotein particle uptake leads to foam cell formation, which is an early event in the development of @entity3 . Currently, mechanisms responsible for foam cell formation are incompletely understood. To date, several macrophage receptors have been identified that contribute to the uptake of modified forms of lipoproteins leading to foam cell formation, but the contribution of the @entity6 ( @entity6 ) to this process is not known. To investigate the role of @entity6 in @entity1 accumulation in macrophages, we generated @entity0 with a selective deletion of @entity6 in macrophages on an @entity4 ( @entity4 )-deficient background (macLRP1-/-). After feeding @entity0 a high fat diet for 11 weeks, peritoneal macrophages isolated from @entity6 +/+ @entity0 contained significantly higher levels of total @entity1 than those from macLRP1-/- @entity0 . Further analysis revealed that this was due to increased levels of @entity5 . Interestingly, macLRP1-/- @entity0 displayed elevated plasma @entity1 and @entity2 levels resulting from accumulation of large, @entity2 -rich lipoprotein particles in the circulation. This increase did not result from an increase in hepatic VLDL biosynthesis, but rather results from a defect in catabolism of @entity2 -rich lipoprotein particles in macLRP1-/- @entity0 . These studies reveal an important in vivo contribution of macrophage @entity6 to @entity1 homeostasis.

title: XXXX -Related Protein-1 ( @entity6 ) Regulates @entity1 Accumulation in Macrophages.

answer: @entity4


abstract: UNASSIGNED: Within the circulation, @entity1 is transported by lipoprotein particles and is taken up by cells when these particles associate with cellular receptors. In macrophages, excessive lipoprotein particle uptake leads to foam cell formation, which is an early event in the development of @entity3 . Currently, mechanisms responsible for foam cell formation are incompletely understood. To date, several macrophage receptors have been identified that contribute to the uptake of modified forms of lipoproteins leading to foam cell formation, but the contribution of the @entity6 ( @entity6 ) to this process is not known. To investigate the role of @entity6 in @entity1 accumulation in macrophages, we generated @entity0 with a selective deletion of @entity6 in macrophages on an @entity4 ( @entity4 )-deficient background (macLRP1-/-). After feeding @entity0 a high fat diet for 11 weeks, peritoneal macrophages isolated from @entity6 +/+ @entity0 contained significantly higher levels of total @entity1 than those from macLRP1-/- @entity0 . Further analysis revealed that this was due to increased levels of @entity5 . Interestingly, macLRP1-/- @entity0 displayed elevated plasma @entity1 and @entity2 levels resulting from accumulation of large, @entity2 -rich lipoprotein particles in the circulation. This increase did not result from an increase in hepatic VLDL biosynthesis, but rather results from a defect in catabolism of @entity2 -rich lipoprotein particles in macLRP1-/- @entity0 . These studies reveal an important in vivo contribution of macrophage @entity6 to @entity1 homeostasis.

title: @entity4 -Related Protein-1 ( @entity6 ) Regulates XXXX Accumulation in Macrophages.

answer: @entity1


abstract: UNASSIGNED: Within the circulation, @entity1 is transported by lipoprotein particles and is taken up by cells when these particles associate with cellular receptors. In macrophages, excessive lipoprotein particle uptake leads to foam cell formation, which is an early event in the development of @entity3 . Currently, mechanisms responsible for foam cell formation are incompletely understood. To date, several macrophage receptors have been identified that contribute to the uptake of modified forms of lipoproteins leading to foam cell formation, but the contribution of the @entity6 ( @entity6 ) to this process is not known. To investigate the role of @entity6 in @entity1 accumulation in macrophages, we generated @entity0 with a selective deletion of @entity6 in macrophages on an @entity4 ( @entity4 )-deficient background (macLRP1-/-). After feeding @entity0 a high fat diet for 11 weeks, peritoneal macrophages isolated from @entity6 +/+ @entity0 contained significantly higher levels of total @entity1 than those from macLRP1-/- @entity0 . Further analysis revealed that this was due to increased levels of @entity5 . Interestingly, macLRP1-/- @entity0 displayed elevated plasma @entity1 and @entity2 levels resulting from accumulation of large, @entity2 -rich lipoprotein particles in the circulation. This increase did not result from an increase in hepatic VLDL biosynthesis, but rather results from a defect in catabolism of @entity2 -rich lipoprotein particles in macLRP1-/- @entity0 . These studies reveal an important in vivo contribution of macrophage @entity6 to @entity1 homeostasis.

title: @entity4 -Related Protein-1 ( XXXX ) Regulates @entity1 Accumulation in Macrophages.

answer: @entity6


abstract: UNASSIGNED: A highly sensitive flow injection analysis (FIA)-based thermal enzyme-linked immunoassay, TELISA, was developed for the rapid detection of @entity3 ( @entity2 ) in tap water. @entity2 and b-lactamase-labeled @entity2 were employed in a competitive immunoassay using a monoclonal antibody (mAb). After the off-column liquid-phase competition, the mAb was captured on the Protein G Sepharose    4 Fast Flow (PGSFF) column support material. Injected b-lactamase substrate @entity1 was degraded by the column-bound @entity2 -b-lactamase, generating a detectable heat signal. Several assay parameters were optimized, including substrate concentration, flow rates and regeneration conditions, as well as the mAb and @entity2 -b dilution ratios and concentrations. The assay linear range was 0.73-4.83 ng mL(-1) with a detection limit of 0.66 ng mL(-1). An entire heat signal requires 10 min for generation, and the cycle time is less than 40 min. The results were reproducible and stable. @entity2 -spiked tap water samples exhibited a recovery rate of 103%-116%, which correlated with the UHPLC- @entity0 / @entity0 measurements. We attributed this significant increase in sensitivity over our previously published work to the following factors: (i) the capture of already-formed immune complexes on the column via immobilized Protein G, which eliminated chemical immobilization of the antibody; (ii) off-column preincubation allows the formation of immune complexes under nearly ideal conditions; and (iii) multiple buffers can be used to, in one case, enhance immune-complex formation and in the other to maximize enzymatic activity. Furthermore, the scheme creates a universal assay platform in which sensing is performed in the off-column incubation and detection after capture in the enzyme thermistor (ET) detector, which opens up the possibility of detecting any antigen for which antibodies were available.

title: Sensitive detection of XXXX in tap water using TELISA.

answer: @entity3


abstract: UNASSIGNED: @entity1 , especially @entity4 ( @entity4 ), represents enormous challenges in continuously achieving treatment improvements. Besides @entity2 , @entity3 is becoming ever more prevalent. Obesity is increasingly acknowledged as a major risk factor for several types of common @entity2 . Significant mechanisms overlap in the pathobiology of @entity3 and tumorigenesis. One of these mechanisms involves @entity5 ( @entity5 ), as a link between @entity3 and @entity2 . Additionally, body mass index (BMI) has been widely used in exploiting the role of @entity3 on a series of diseases, including @entity2 . Significantly, squamous @entity4 revealed to be divergent clinical and molecular phenotypes compared with non-squamous @entity4 . Consequently, @entity5 immunostaining score and BMI were assessed by Fisher's linear discriminant analysis to discriminate if progression-free survival (PFS) would exceed 2 years. In addition, the final model was utilized to calculate the discriminant score in each study @entity0 . Finally, 131 @entity0 with squamous NCSLC were eligible for analysis. And a prediction model was established for PFS based on these 2 markers and validated in a second set of squamous NCSLC @entity0 . The model offers a novel tool for survival prediction and could establish a framework for future individualized therapy for @entity0 with squamous NCSLC.

title: Combination of body mass index and @entity5 in prognosis prediction of @entity0 with squamous XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity1 , especially @entity4 ( @entity4 ), represents enormous challenges in continuously achieving treatment improvements. Besides @entity2 , @entity3 is becoming ever more prevalent. Obesity is increasingly acknowledged as a major risk factor for several types of common @entity2 . Significant mechanisms overlap in the pathobiology of @entity3 and tumorigenesis. One of these mechanisms involves @entity5 ( @entity5 ), as a link between @entity3 and @entity2 . Additionally, body mass index (BMI) has been widely used in exploiting the role of @entity3 on a series of diseases, including @entity2 . Significantly, squamous @entity4 revealed to be divergent clinical and molecular phenotypes compared with non-squamous @entity4 . Consequently, @entity5 immunostaining score and BMI were assessed by Fisher's linear discriminant analysis to discriminate if progression-free survival (PFS) would exceed 2 years. In addition, the final model was utilized to calculate the discriminant score in each study @entity0 . Finally, 131 @entity0 with squamous NCSLC were eligible for analysis. And a prediction model was established for PFS based on these 2 markers and validated in a second set of squamous NCSLC @entity0 . The model offers a novel tool for survival prediction and could establish a framework for future individualized therapy for @entity0 with squamous NCSLC.

title: Combination of body mass index and XXXX in prognosis prediction of @entity0 with squamous @entity4 .

answer: @entity5


abstract: UNASSIGNED: @entity1 , especially @entity4 ( @entity4 ), represents enormous challenges in continuously achieving treatment improvements. Besides @entity2 , @entity3 is becoming ever more prevalent. Obesity is increasingly acknowledged as a major risk factor for several types of common @entity2 . Significant mechanisms overlap in the pathobiology of @entity3 and tumorigenesis. One of these mechanisms involves @entity5 ( @entity5 ), as a link between @entity3 and @entity2 . Additionally, body mass index (BMI) has been widely used in exploiting the role of @entity3 on a series of diseases, including @entity2 . Significantly, squamous @entity4 revealed to be divergent clinical and molecular phenotypes compared with non-squamous @entity4 . Consequently, @entity5 immunostaining score and BMI were assessed by Fisher's linear discriminant analysis to discriminate if progression-free survival (PFS) would exceed 2 years. In addition, the final model was utilized to calculate the discriminant score in each study @entity0 . Finally, 131 @entity0 with squamous NCSLC were eligible for analysis. And a prediction model was established for PFS based on these 2 markers and validated in a second set of squamous NCSLC @entity0 . The model offers a novel tool for survival prediction and could establish a framework for future individualized therapy for @entity0 with squamous NCSLC.

title: Combination of body mass index and @entity5 in prognosis prediction of XXXX with squamous @entity4 .

answer: @entity0


abstract: UNASSIGNED: Monocytes are heterogeneous cells consisting of (at least) three subsets: classical, intermediate, and nonclassical monocytes. Correct enumeration of cell counts necessitates well-defined gating strategies, which are essentially based upon @entity3 and @entity2 expression. For the delineation of intermediate from nonclassical monocytes, a "rectangular gating (RG) strategy" and a "trapezoid gating (TG) strategy" have been proposed. We compared the two gating strategies in a well-defined clinical cohort of @entity0 with @entity1 ( @entity1 ). Within the ongoing CARE FOR HOMe study, monocyte subsets were reanalyzed in 416 @entity1 @entity0 , who were followed 3.6        1.6 years for the occurrence of a cardiovascular event. Gating was performed by either RG or TG. We analyzed the expression of surface markers, and compared the predictive role of cell counts of monocyte subsets, as defined by RG and TG, respectively. With both gating strategies, higher intermediate monocyte counts predicted the cardiovascular endpoint in Kaplan-Meier analyses (P   <   0.001 with RG; P   <   0.001 with TG). After correction for confounders, intermediate monocyte counts remained independent predictors in Cox-Regression analyses (HR   =   1.013 [95% CI: 1.006-1.020; P   <   0.001] with RG; HR   =   1.015 [95% CI: 1.006-1.024; P   =   0.001] with TG). NRI was 3.9% when reclassifying @entity0 from quartiles of intermediate monocyte counts with RG strategy toward quartiles of intermediate monocytes counts with TG strategy. In expression analysis, those monocytes which are defined as intermediate monocytes by the RG strategy and as nonclassical monocytes by the TG strategy share characteristics of both subsets. In conclusion, intermediate monocytes were independent predictors of cardiovascular outcome irrespective of the applied gating strategy. Future studies should aim to identify markers that allow for an unequivocal definition of intermediate monocytes, which may further improve their power to predict cardiovascular events.    2015 International Society for Advancement of Cytometry.

title: Comparison of two different strategies for XXXX monocyte subsets gating within the large-scale prospective CARE FOR HOMe Study.

answer: @entity0


abstract: Suspected adverse drug reactions may be subdivided on the basis of mechanism e.g. immunological (requiring sensitisation by previous exposure) versus nonimmunological; timing (e.g. immediate or delayed), or whether the phenomenon is dose dependent or not. In the NICE guideline the main approach is to classify the event according to whether it: is immediate (within an hour of drug administration) or delayed (hours or days); affects a single or multiple systems; is clinically severe/life threatening or not. An immediate, immunologically mediated, multisystem, life-threatening reaction would for example include @entity6 (type 1 or typically IgE- mediated @entity1 ) especially if the clinical features (e.g. @entity7 , @entity4 ) are suggestive. Serum mast cell tryptase should be tested ideally within two hours and certainly before four hours post reaction. Detailed investigation of suspected cases in a specialist clinic is ideally delayed for 4-6 weeks after the event. @entity3 need to be meticulously recorded and the @entity0 fully informed. Documentation should include: date of reaction; drug name (chemical and generic); route of administration; time interval between first dose and event; and nature and severity of symptoms. Written guidance should be provided on which other chemically related drugs also need to be avoided. Specialist referral is indicated for: suspected @entity6 ; severe/life- threatening episodes e.g. @entity8 ; severe NSAID reactions with ongoing need for NSAID therapy; suspected @entity2 @entity5 (if alternative antibiotics are not available); and problems related to general and local anaesthesia.

title: Improving detection and management of XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity8 ( @entity8 ) and atypical @entity6 (aHUS) are distinct clinical disorders characterized by @entity9 , @entity5 , microthrombi, and @entity2 . @entity8 is characterized by a low @entity7 activity level at diagnosis of <10  % @entity7 activity, while aHUS is characterized as having >10  % @entity7 activity. Despite clinical remission, survivors of @entity10 suffer significant comorbidity and decreased quality of life (QOL) than their healthy counterparts. The reason for this is unclear. Is it a lingering effect from their initial acute episode or ongoing subclinical @entity3 despite clinical remission? Common clinical complaints validated in practice include @entity4 , deficits in memory, concentration, mood, and mental endurance. We suspect @entity1 may be an important clinical tool toward understanding @entity0 morbidity and decreased QOL. To date, no studies report @entity1 frequency or severity in this population. To answer this question, adult @entity0 >3  months since their last acute episode of @entity8 or aHUS were approached to take a @entity1 Impact Test (HIT-6) survey. Between June 1, 2013 and May 30, 2014, 31 @entity0 in remission (21 @entity0 with prior @entity8 and 10 @entity0 with prior aHUS) completed the HIT-6 survey. The survey scores were then compared to the HIT-6 normative population data established by Qualitymetric incorporated. Overall, @entity8 @entity0 had a significantly higher average HIT-6 score of 59.9 compared to an average HIT-6 score of 51 seen in sex-matched controls (SD 9.6, p value 0.002). No significant difference was seen in the HIT-6 scores of aHUS @entity0 . Of @entity8 @entity0 studied, approximately 57  % (12/21) had three or more episodes and were >24  months since the last episode. The average time since last acute episode in @entity8 @entity0 was 37.5  months. There was no significant correlation between @entity8 survivor @entity11 of prior episodes (1, 2, or >3) or timing from the last episode (3-6, 7-12, 13-24, or >24  months). About 19/21 (90  %) @entity0 , who are @entity8 survivors, also had a normal @entity7 activity level (>10  %) on the day of the survey. Our study suggests that @entity1 have significant impact on @entity8 survivors and should be followed in the clinical setting to prevent undue @entity0 morbidity. Larger studies are needed to understand how @entity1 impact long-term survival and risk of relapse.

title: XXXX prevalence following recovery from @entity8 and aHUS.

answer: @entity1


abstract: UNASSIGNED: @entity8 ( @entity8 ) and atypical @entity6 (aHUS) are distinct clinical disorders characterized by @entity9 , @entity5 , microthrombi, and @entity2 . @entity8 is characterized by a low @entity7 activity level at diagnosis of <10  % @entity7 activity, while aHUS is characterized as having >10  % @entity7 activity. Despite clinical remission, survivors of @entity10 suffer significant comorbidity and decreased quality of life (QOL) than their healthy counterparts. The reason for this is unclear. Is it a lingering effect from their initial acute episode or ongoing subclinical @entity3 despite clinical remission? Common clinical complaints validated in practice include @entity4 , deficits in memory, concentration, mood, and mental endurance. We suspect @entity1 may be an important clinical tool toward understanding @entity0 morbidity and decreased QOL. To date, no studies report @entity1 frequency or severity in this population. To answer this question, adult @entity0 >3  months since their last acute episode of @entity8 or aHUS were approached to take a @entity1 Impact Test (HIT-6) survey. Between June 1, 2013 and May 30, 2014, 31 @entity0 in remission (21 @entity0 with prior @entity8 and 10 @entity0 with prior aHUS) completed the HIT-6 survey. The survey scores were then compared to the HIT-6 normative population data established by Qualitymetric incorporated. Overall, @entity8 @entity0 had a significantly higher average HIT-6 score of 59.9 compared to an average HIT-6 score of 51 seen in sex-matched controls (SD 9.6, p value 0.002). No significant difference was seen in the HIT-6 scores of aHUS @entity0 . Of @entity8 @entity0 studied, approximately 57  % (12/21) had three or more episodes and were >24  months since the last episode. The average time since last acute episode in @entity8 @entity0 was 37.5  months. There was no significant correlation between @entity8 survivor @entity11 of prior episodes (1, 2, or >3) or timing from the last episode (3-6, 7-12, 13-24, or >24  months). About 19/21 (90  %) @entity0 , who are @entity8 survivors, also had a normal @entity7 activity level (>10  %) on the day of the survey. Our study suggests that @entity1 have significant impact on @entity8 survivors and should be followed in the clinical setting to prevent undue @entity0 morbidity. Larger studies are needed to understand how @entity1 impact long-term survival and risk of relapse.

title: @entity1 prevalence following recovery from XXXX and aHUS.

answer: @entity8


abstract: UNASSIGNED: For locally advanced @entity0 , pathological complete response (pCR) following neoadjuvant chemotherapy (NACT) is associated with good disease-free survival. In several studies, response to chemotherapy according to various parameters has shown strong inter-individual variability. We investigated whether different prognostic factors, including @entity4 expression, might predict response to NACT in female @entity1 with locally advanced @entity0 . ER, PR, @entity3 , Ki-67 and @entity4 immunohistochemistry were performed on the initial biopsy and subsequent resection specimens. @entity2 burden was calculated in post NACT resection specimens using @entity2 ( @entity2 ) protocol. Of our cohort of 66 @entity1 , 24 (36  %) achieved pCR. Triple negative phenotype and high Ki-67 proliferative index (>40  %) were significantly associated with good response to NACT. @entity4 expression in @entity2 epithelial (20  %) or stromal (44  %) cells did not correlate with @entity2 grade, molecular subtype, proliferative index or NACT response. However, epithelial and stromal @entity4 expression was significantly increased in @entity2 after NACT. In conclusion, triple negative phenotype and high proliferative index, but not @entity4 expression, are predictive of good pathological response to NACT. Increased @entity4 expression following NACT might be associated with a higher probability of recurrent disease.

title: Proliferation rate and @entity0 subtype, but not @entity4 expression, predict pathological response to neoadjuvant chemotherapy in locally advanced XXXX .

answer: @entity0


abstract: UNASSIGNED: For locally advanced @entity0 , pathological complete response (pCR) following neoadjuvant chemotherapy (NACT) is associated with good disease-free survival. In several studies, response to chemotherapy according to various parameters has shown strong inter-individual variability. We investigated whether different prognostic factors, including @entity4 expression, might predict response to NACT in female @entity1 with locally advanced @entity0 . ER, PR, @entity3 , Ki-67 and @entity4 immunohistochemistry were performed on the initial biopsy and subsequent resection specimens. @entity2 burden was calculated in post NACT resection specimens using @entity2 ( @entity2 ) protocol. Of our cohort of 66 @entity1 , 24 (36  %) achieved pCR. Triple negative phenotype and high Ki-67 proliferative index (>40  %) were significantly associated with good response to NACT. @entity4 expression in @entity2 epithelial (20  %) or stromal (44  %) cells did not correlate with @entity2 grade, molecular subtype, proliferative index or NACT response. However, epithelial and stromal @entity4 expression was significantly increased in @entity2 after NACT. In conclusion, triple negative phenotype and high proliferative index, but not @entity4 expression, are predictive of good pathological response to NACT. Increased @entity4 expression following NACT might be associated with a higher probability of recurrent disease.

title: Proliferation rate and XXXX subtype, but not @entity4 expression, predict pathological response to neoadjuvant chemotherapy in locally advanced @entity0 .

answer: @entity0


abstract: UNASSIGNED: For locally advanced @entity0 , pathological complete response (pCR) following neoadjuvant chemotherapy (NACT) is associated with good disease-free survival. In several studies, response to chemotherapy according to various parameters has shown strong inter-individual variability. We investigated whether different prognostic factors, including @entity4 expression, might predict response to NACT in female @entity1 with locally advanced @entity0 . ER, PR, @entity3 , Ki-67 and @entity4 immunohistochemistry were performed on the initial biopsy and subsequent resection specimens. @entity2 burden was calculated in post NACT resection specimens using @entity2 ( @entity2 ) protocol. Of our cohort of 66 @entity1 , 24 (36  %) achieved pCR. Triple negative phenotype and high Ki-67 proliferative index (>40  %) were significantly associated with good response to NACT. @entity4 expression in @entity2 epithelial (20  %) or stromal (44  %) cells did not correlate with @entity2 grade, molecular subtype, proliferative index or NACT response. However, epithelial and stromal @entity4 expression was significantly increased in @entity2 after NACT. In conclusion, triple negative phenotype and high proliferative index, but not @entity4 expression, are predictive of good pathological response to NACT. Increased @entity4 expression following NACT might be associated with a higher probability of recurrent disease.

title: Proliferation rate and @entity0 subtype, but not XXXX expression, predict pathological response to neoadjuvant chemotherapy in locally advanced @entity0 .

answer: @entity4


abstract: BACKGROUND: This population-based study sought to quantify maternal, fetal, and neonatal morbidity and mortality in low- and middle-income countries associated with @entity4 and failure to progress (OL/PL/FTP). METHODS: A prospective, population-based observational study of pregnancy outcomes was performed at seven sites in Argentina, Guatemala, India (2 sites, Belgaum and Nagpur), Kenya, Pakistan and Zambia. @entity0 were enrolled in pregnancy and delivery and 6-week follow-up obtained to evaluate rates of OL/PL/FTP and outcomes resulting from OL/PL/FTP, including: maternal and delivery characteristics, maternal and neonatal morbidity and mortality and stillbirth. RESULTS: Between 2010 and 2013, 266,723 of 267,270 records (99.8%) included data on OL/PL/FTP with an overall rate of 110.4/1000 deliveries that ranged from 41.6 in Zambia to 200.1 in Pakistan. OL/PL/FTP was more common in @entity0 aged <20, nulliparous @entity0 , more educated @entity0 , @entity0 with @entity0 >3500g, and @entity0 with a BMI >25 (RR 1.4, 95% CI 1.3 - 1.5), with the suggestion of OL/PL/FTP being less common in preterm deliveries. Protective characteristics included parity of >= 3, having an @entity0 <1500g, and having a BMI <18. @entity0 with OL/PL/FTP were more likely to die within 42 days (RR 1.9, 95% CI 1.4 - 2.4), be infected (RR 1.8, 95% CI 1.5 - 2.2), and have @entity3 antepartum (RR 2.8, 95% CI 2.1 - 3.7) or postpartum (RR 2.4, 95% CI 1.8 - 3.3). They were also more likely to have a stillbirth (RR 1.6, 95% CI 1.3 - 1.9), a neonatal demise at < 28 days (RR 1.9, 95% CI 1.6 - 2.1), or a @entity2 (RR 1.2, 95% CI 1.1 - 1.3). As compared to operative vaginal delivery and cesarean section (CS), @entity0 experiencing OL/PL/FTP who gave birth vaginally were more likely to become infected, to have an infected neonate, to @entity3 in the antepartum and postpartum period, and to die, have a stillbirth, or have a neonatal demise. @entity0 with OL/PL/FTP were far more likely to deliver in a facility and be attended by a physician or other skilled provider than @entity0 without this diagnosis. CONCLUSIONS: @entity0 with OL/PL/FTP in the communities studied were more likely to be primiparous, younger than age 20, overweight, and of higher education, with an @entity0 with birthweight of >3500g. @entity0 with this diagnosis were more likely to experience a maternal, fetal, or @entity1 , antepartum and postpartum @entity3 , and @entity2 . They were also more likely to deliver in a facility with a skilled provider. CS may decrease the risk of poor outcomes (as in the case of antepartum @entity3 ), but unassisted vaginal delivery exacerbates all of the maternal, fetal, and neonatal outcomes evaluated in the setting of OL/PL/FTP.

title: A prospective population-based study of maternal, fetal, and neonatal outcomes in the setting of XXXX and failure to progress in low- and middle-income countries.

answer: @entity4


abstract: @entity1 is the most common @entity4 in @entity0 . One of the major complications of the disease is foot ulcer that is prone to @entity5 . The most common causes of @entity5 which have been reported in these @entity0 are bacteria and fungi such as Candida, Aspergillus, and Rhizopus species. We report one such rare case with @entity9 caused by Aspergillus ochraceus in a @entity0 with @entity1 . The case was a 68-year-old male with a history of @entity8 for 2 years. The @entity0 had two @entity7 on the right heel bones for the past 6 months with no significant improvement. One of the most important predisposing factors to @entity3 , especially opportunistic @entity6 , is @entity1 . Aspergillus species can involve bony tissue through vascular system, direct @entity5 , and @entity2 . Proper and early diagnosis and treatment of @entity1 can reduce or prevent complications, such as @entity9 and amputation. The annual examination of feet for skin and nail lesion, sensation, anatomical changes, and vascular circulation can be useful for prevention and control of @entity5 .

title: Rare Case of Aspergillus ochraceus Osteomyelitis of Calcaneus Bone in a XXXX with Diabetic Foot Ulcers.

answer: @entity0


abstract: @entity0 embryonic stem cells (hESCs) are able to proliferate in vitro indefinitely without losing their ability to differentiate into multiple cell types upon exposure to appropriate signals. Particularly, the ability of hESCs to differentiate into neuronal subtypes is fundamental to develop cell-based therapies for several @entity1 , such as @entity3 , @entity5 , and @entity2 . In this study, we differentiated hESCs to dopaminergic neurons via an intermediate stage, neural progenitor cells (NPCs). hESCs were induced to neural progenitor cells by @entity11 , a small molecule that inhibits BMP signalling. The resulting neural progenitor cells exhibited neural bipolarity with high expression of neural progenitor genes and possessed multipotential differentiation ability. @entity7 and @entity4 responsiveness of these hES-NP cells suggested their similarity to embryonic neural progenitor cells. A substantial number of dopaminergic neurons were derived from hES-NP cells upon supplementation of @entity9 and @entity6 , key dopaminergic neuron inducers. Importantly, multiple markers of midbrain neurons were detected, including @entity8 , @entity12 , and @entity10 , suggesting that hESC-derived dopaminergic neurons attained the midbrain identity. Altogether, this work underscored the generation of neural progenitor cells that retain the properties of embryonic neural progenitor cells. These cells will serve as an unlimited source for the derivation of dopaminergic neurons, which might be applicable for treating @entity0 with @entity2 .

title: Neural Progenitor Cells Derived from XXXX Embryonic Stem Cells as an Origin of Dopaminergic Neurons.

answer: @entity0


abstract: AIMS: This study is to determine the effect of astragalus and salvia extract on the alteration of myocardium in a @entity0 model of @entity2 . METHODS: A total of 40 male @entity0 were randomly divided into the sham-operated group, the control group, the Astragalus group, the Salvia group, and the compatibility of Astragalus and Salvia and group. The cardiac functions were determined at 8 weeks after treatment. @entity3 - @entity4 staining was performed to observe the morphology and arrangement of cardiomyocytes. Masson's trichrome staining was performed to investigate the distribution of myocardial interstitial collagen. Immunohistochemical staining was performed to determine the expression ofprotein kinase D1 in myocardial tissues. RESULTS: In the sham-operated group, the Astragalus group, the Salvia group, and the compatibility of Astragalus and Salvia group, the left ventricular systolic pressure and the maximum rate of left ventricular pressure were significantly increased while the left ventricular end diastolic pressure were significantly decreased when compared with those in the control group (P < 0.05). Normal morphology and arrangement of cardiomyocytes were maintained in the compatibility of Astragalus and Salvia group. Contents of collagen fibers in myocardial tissues were decreased in the compatibility of Astragalus and Salvia group (P < 0.05). Expression levels of protein kinase D1 were significantly decreased in cardiomyocytes of the compatibility of Astragalus and Salvia group. CONCLUSIONS: Compatibility of Astragalus and Salvia extract may inhibit @entity1 and ventricular remodeling by regulation of protein kinase D1 protein in a @entity0 model of @entity2 .

title: Compatibility of Astragalus and Salvia extract inhibits XXXX and ventricular remodeling by regulation of protein kinase D1 protein.

answer: @entity1


abstract: @entity0 transport in the plasma involves several lipoprotein families. The process is remarkably ordered and is driven vectorily by apolipoproteins, which activate appropriate enzymes or serve as recognition sites for lipoprotein receptors. Of the lipoproteins in plasma, low density lipoprotein (LDL) contains most of the @entity0 and has the greatest atherogenic potential. Its plasma concentration is determined by @entity1 activity, which serves to regulate intracellular @entity0 concentrations. @entity1 activity in the body is not fixed, but can be stimulated by drugs that affect hepatic @entity0 content, such as inhibitors of @entity2 reductase or @entity4 sequestrants. By stimulating @entity1 activity, these drugs increase the fractional catabolic rate of apoLDL. @entity2 reductase inhibitors also appear to reduce the apoLDL synthetic rate. As a consequence, LDL @entity0 levels are reduced while high density lipoprotein (HDL) @entity0 levels remain stable or increase. @entity3 is a drug that lowers both LDL and HDL @entity0 levels. It appears to lower LDL @entity0 levels by affecting LDL structure rather than by stimulating @entity1 activity. It has no consistent effect on LDL synthetic rates. @entity3 lowers plasma HDL @entity0 levels by decreasing the synthetic rates of the major HDL apolipoproteins. The biologic significance of these @entity3 -induced changes in HDL metabolism is unknown.

title: Lipoprotein fractions and receptors: a role for XXXX ?

answer: @entity3


abstract: UNASSIGNED: Accumulating evidence has shown that @entity3 -196a plays an important role in tumorigenesis and @entity2 progression in various types of @entity2 . miRNA profiling studies have suggested that @entity3 -196a is highly overexpressed in @entity0 . However, the functional mechanism of @entity3 -196a in @entity0 remains unclear. In the present study, we first showed that the expression of @entity3 -196a was significantly upregulated in @entity1 @entity0 cell lines. Using a loss-of-function approach, we showed that the downregulation of @entity3 -196a inhibited the proliferation of @entity0 cells in  vitro and in  vivo. @entity4 ( @entity4 ) gene as a cellular proto-oncogene, which was overexpressed and positively correlated with @entity3  -196a expression in @entity0 tissues, was identified as a direct target of @entity3 -196a. Moreover, in order to investigate whether @entity3 -196a regulated cell growth in @entity0 cells by targeting @entity4 , rescue studies were performed in @entity0 cells. The restoration of @entity4 by transfecting @entity4 cDNA in anti- @entity3 -196a-tranfected @entity0 cells rescued the suppression of cell proliferation. In conclusion, the present study showed that @entity3 -196a promoted cell proliferation by targeting @entity4 in @entity0 . Thus, @entity3 -196a may be a potential oncogene in @entity0 and a promising therapeutic target in @entity0 treatment.

title: MicroRNA-196a post-transcriptionally upregulates the @entity4 proto-oncogene and promotes cell proliferation in XXXX .

answer: @entity0


abstract: UNASSIGNED: Accumulating evidence has shown that @entity3 -196a plays an important role in tumorigenesis and @entity2 progression in various types of @entity2 . miRNA profiling studies have suggested that @entity3 -196a is highly overexpressed in @entity0 . However, the functional mechanism of @entity3 -196a in @entity0 remains unclear. In the present study, we first showed that the expression of @entity3 -196a was significantly upregulated in @entity1 @entity0 cell lines. Using a loss-of-function approach, we showed that the downregulation of @entity3 -196a inhibited the proliferation of @entity0 cells in  vitro and in  vivo. @entity4 ( @entity4 ) gene as a cellular proto-oncogene, which was overexpressed and positively correlated with @entity3  -196a expression in @entity0 tissues, was identified as a direct target of @entity3 -196a. Moreover, in order to investigate whether @entity3 -196a regulated cell growth in @entity0 cells by targeting @entity4 , rescue studies were performed in @entity0 cells. The restoration of @entity4 by transfecting @entity4 cDNA in anti- @entity3 -196a-tranfected @entity0 cells rescued the suppression of cell proliferation. In conclusion, the present study showed that @entity3 -196a promoted cell proliferation by targeting @entity4 in @entity0 . Thus, @entity3 -196a may be a potential oncogene in @entity0 and a promising therapeutic target in @entity0 treatment.

title: MicroRNA-196a post-transcriptionally upregulates the XXXX proto-oncogene and promotes cell proliferation in @entity0 .

answer: @entity4


abstract: A total of 37 cases of @entity6 , in @entity0 aged two days to 13 years, were seen from 1971 to 1983 at the @entity0 's Hospital, Camperdown. @entity4 was known to preexist in 95%. @entity4 was present in 15 @entity0 , of whom 11 had been palliated by a systemic-to-pulmonary artery shunt. In five @entity0 , there was @entity3 of a prosthetic valve. Identifiable precipitants of @entity3 were rare. In particular, no @entity0 had had a preceding dental procedure within three months, while only 19% had had recent cardiac surgery. Organisms were identified by blood culture in 92%, the majority being streptococci (43% of cases) and staphylococci (27% of cases). While 59% of all organisms were @entity1 sensitive, six of the seven early postoperative @entity0 were infected with organisms not sensitive to antibiotics, given for wound @entity3 prophylaxis in the perioperative period. The overall death rate was 13.5%. Of the @entity0 infected with @entity5 , 40% died, while no @entity0 with Streptococcus viridans @entity6 died. Of the survivors, four needed urgent valve replacement, and three had @entity2 . Using these figures, a current profile of @entity0 with @entity6 is presented.

title: XXXX in childhood.

answer: @entity6


abstract: BACKGROUND: Acute stress in @entity0 experiencing @entity1 diagnosis and the @entity11 in @entity1 survivors results in impaired overall quality of life mainly due to associated psychological and physical alterations, including @entity4 , @entity6 , @entity2 , @entity3 , @entity12 , @entity5 , @entity13 and others. Recent studies revealed a new insight into molecular mechanisms contributing to the development of @entity1 . It has been shown that adverse psychosomatic reactions including @entity1 @entity1 result from @entity7 , disruption of the @entity9 and sympathetic nervous system, @entity8 - @entity10 interactions and circadian sleep-wake rhythm disruption. AIM: The aim of the present study was to evaluate clinical studies oriented toward elucidation of the hypothesis that @entity1 is the @entity14 leading to the development of accompanying @entity15 . MATERIAL AND METHODS: The data of the biopsychosocial approach in the treatment of @entity1 presented in the current literature were collecting using appropriate electronic databases and were elaborated in the form of meta-analysis of 24 selected publications. RESULTS: According to relevant clinical studies, psychosocial interventions and psychopharmacological treatment has been shown to reduce @entity1 symptomatology and to improve the ability of @entity0 to cope with the disease. Thus, one of the key pillars of supportive care in oncology is stress reduction. Cognitive-behavioral interventions and group psychosocial therapies have shown to reduce stress from the diagnosis and treatment, to palliate @entity6 and to help in restoring the circadian rhythm. Psychopharamacological interventions are the most useful approaches in the reduction of stress-induced @entity1 comorbidities. In the presented study, a plausible role of stress reduction in the protection of @entity1 @entity0 from posttraumatic and @entity6 , physical and psychical suffering, from decrease of @entity0 quality of life, ability to cope with the disease and cooperate in @entity1 treatment has been analyzed. CONCLUSION: Implementation of the biopsychosocial model of @entity1 care needs further cooperation between behavioral scientists and clinical oncologists attempted to elucidate further possibilities of psychosocial and pharmacological interventions leading to the regulation of stress-induced alterations of the neurotransmitter system and @entity7 reduction of @entity1 and improvement of @entity0 survival time.Key words: @entity1 - behavioral risk profile - @entity6 - @entity7 - psychosocial and pharmacological intervention The authors declare they have no potential conflicts of interest concerning drugs, products, or   services used in the study. The Editorial Board declares that the manuscript met the ICMJE "uniform requirements" for biomedical papers.Submitted: 30. 7. 2014Accepted: 8. 4. 2015.

title: [Anxio- XXXX Syndrome - Biopsychosocial Model of Supportive Care].

answer: @entity6


abstract: UNASSIGNED: @entity0 with chronic @entity4 (CPD) exhibit deficient sensorimotor gating (measured by prepulse inhibition (PPI) of @entity3 ) and @entity8 ( @entity8 ). In healthy subjects (HS), @entity5 ( @entity5 ) antagonists like @entity6 and @entity7 increase PPI, and under some conditions, @entity6 enhances @entity8 ; these findings present a challenge to understanding the basis for @entity8 in @entity4 , as reduced @entity5 activity is implicated in the pathogenesis of these disorders. Here we assessed for the first time the effects of @entity6 on PPI and @entity8 in CPD subjects. Baseline PPI was measured in HS and @entity0 with a diagnosis of @entity1 or @entity4 , @entity2 . Subjects (total n=84) were then tested twice, in a double-blind crossover design, comparing either: (1) placebo vs 10   mg of @entity6 or (2) placebo vs 20   mg @entity6 . Tests included measures of acoustic @entity3 magnitude and habituation, PPI, @entity8 , autonomic indices, and subjective self-rating scales. @entity6 (20   mg) significantly enhanced PPI in CPD subjects, and enhanced @entity8 across subject groups. These effects on PPI were age dependent and most evident in older CPD @entity0 , whereas those on @entity8 were most evident in younger subjects. The lower dose (10   mg) either had no detectable effect or tended to degrade these measures. The @entity5 antagonist, @entity6 , has dose-dependent effects on preconscious, automatic measures of sensorimotor gating and auditory sensory processing that are associated with enhanced cognition and function in CPD @entity0 . Ongoing studies will determine whether these @entity6 -induced changes predict acute pro-cognitive or otherwise clinically beneficial effects in CPD @entity0 .Neuropsychopharmacology advance online publication, 1 July 2015; doi:10.1038/npp.2015.162.

title: XXXX Effects On Sensorimotor Gating and Mismatch Negativity in @entity0 with Chronic Psychosis.

answer: @entity6