abstract: A case of dural @entity13 manifested during pregnancy was reported. On December 28, 1979, a 28-year-old primipara, suddenly developed @entity1 , @entity2 and @entity3 at the 8th month of her pregnancy and soon after became unconscious. She was transferred by ambulance to our hospital. On admission she was @entity6 exhibiting @entity12 . The blood pressure was 126/76 mmHg and the pulse rate 97 per minute and regular. Right pupil was dilated and did not react to light. CT scan revealed a subdural @entity10 on the right side and @entity11 in the right middle fossa. Angiography demonstrated a dural @entity13 in the right anterior middle fossa fed by the middle meningeal artery. @entity8 consisted of the superficial sylvian vein directed toward the superior sagittal sinus. The @entity0 was in no @entity5 , so we only removed subdural @entity10 , decompressed externally and ligated the external carotid artery. The postoperative course was uneventful, the anisocoria was diminished, and the consciousness improved up to @entity7 , but the @entity9 remained. Two months later a 2,760g baby @entity0 was born by Caesarean section without accident. But two weeks later, suddenly she had generalized @entity4 and became @entity6 . CT scan revealed an @entity11 in the middle fossa again. Second operation was performed, and the nidus was electrocoagulated and removed together with the @entity10 . The postoperative course was also uneventful. At present, one and a half years after operation, no symptom of recurrence is observed. @entity11 and dural @entity13 in pregnancy were discussed and the reports in the literature were reviewed.

title: [A case of dural XXXX during pregnancy (author's transl)].

answer: @entity13


abstract: BACKGROUND: Evidence suggests that a significant number of @entity0 receive less than optimal management of procedure-related @entity1 . OBJECTIVES: To determine if there was a difference in the perceived @entity1 associated with a venipuncture procedure in a group of pediatric @entity0 based on the preparatory intervention used during the procedure and, to determine if age, sex, or ethnic group were associated with the effectiveness of the preparatory interventions used. DESIGN: A quasi-experimental, 3*4 factorial design was used. SETTING: @entity0 were recruited from a non-profit, regional hospital in the southeast United States. @entity0 : @entity0 were recruited from @entity0 between the ages of 18 months and 17 years who were admitted to the facility. Criteria for inclusion was the first needle stick during admission with a parent or guardian present, English as the primary language. Potential @entity0 were excluded if they had previous experience with any of the preparatory interventions, were sedated, unconscious, hemodynamically unstable, developmentally delayed for their age, or had a known chronic condition. Of the 285 @entity0 consented to participate, 173 @entity0 completed the process including 35 (20.2%) toddlers, 34(19.7%) preschool and 65 (37.6%) school age @entity0 , and 39 (22.5%) adolescents. There were 77 (44.5%) females and 96 (55.5%) males; and 101 (58.4%) non-Hispanic white @entity0 and 72 (41.6%) minority @entity0 . METHODS: @entity0 were randomized to one of three treatment interventions. There was a purposeful effort to include representative numbers of each age group, ethnic group, and sex and in each treatment group. Measures of @entity1 before and after the procedure included an observational measure completed by the parent/guardian and a self-report measure completed by the two older age groups. FINDINGS: There were no statistically significant differences among treatment groups based on the observational measures of @entity1 or the self-report measures of @entity1 . There was a statistically significant interaction between ethnic group and treatment group (p=0.006) based on the observational measure of @entity1 which was also found between ethnic group and treatment group (p=.04) based on self-report scores in school age @entity0 and adolescents. CONCLUSION: Findings support the use of both mechanical vibration and topical anesthetic as effective in @entity0 regardless of age group or sex. Further, the interaction between ethnic group and treatment contributes to a growing body of knowledge that suggests ethnic group is an important factor in the @entity1 response and requires further study in an effort to better customize approaches to @entity1 management in @entity0 .

title: Mitigating procedural XXXX during venipuncture in a pediatric population: A randomized factorial study.

answer: @entity1


abstract: UNASSIGNED: The present study reports the case of a 68-year-old male @entity0 who presented to Tokyo Rosai Hospital for the treatment of @entity7 . A high density was observed in liver segment S2, while a @entity1 , 30 mm in size, exhibiting a low density was observed in the delayed phase upon contrast-enhanced computed tomography (CT), which was performed prior to admission. The @entity1 appeared slightly poorly defined upon abdominal ultrasound and was observed as a 30 mm low-echoic nodule that was internally heterogeneous. A 5-mm thick contrast enhancement effect was observed in the @entity1 border in the vascular phase on Sonazoid contrast-enhanced ultrasonography, while a defect in the entire @entity1 was observed in the post-vascular phase. @entity6 had commenced three months prior to presentation and a weight loss of ~3 kg was observed. Therefore, the @entity0 was admitted to Tokyo Rosai Hospital due to the presence of a @entity3 , and to undergo a close inspection of the cause of the @entity1 . Upon close inspection, it was determined that the weight loss and aphagia were caused by progressive @entity8 . A contrast-enhanced CT was performed on post-admission day 29 as a follow-up regarding the @entity3 . As a result, although no change in the @entity1 size was observed, the contrast enhancement in the @entity1 borderline had disappeared. Necrosis of the @entity1 was considered. However, as viable persistence of the @entity1 could not be excluded, a hepatic left lobe excision was performed. The @entity0 was diagnosed with @entity4 ( @entity4 ) based on the morphology of the cellular @entity2 . In addition, occlusion due to @entity5 was observed within the blood vessels passing inside the fibrous capsule. It was hypothesized that the formation of a thick fibrous capsule and occlusion due to @entity5 in the feeding vessel were possibly involved as the cause of complete spontaneous @entity2 . Written informed consent was obtained from the @entity0 .

title: XXXX : A case report and review of the literature.

answer: @entity4


abstract: UNASSIGNED: @entity3 is an extremely rare disease that, at present, has not been well characterized. The etiology, diagnosis and treatment of this @entity2 remain poorly understood, particularly in the Chinese population. The aim of the present study was to discuss the methods of diagnosis and treatment of @entity3 in the Chinese population. The clinical and pathological data of 10 @entity0 with @entity3 were analyzed alongside a literature review. All the @entity1 were exophytic papillary lesions, ranging between 0.4 and 4 cm in diameter and all 10 @entity0 underwent partial penectomy with @entity1 -negative surgical margins. None of the 10 @entity0 underwent ilioinguinal lymphadenectomy. All @entity0 were regularly followed up for 0.7-9 years, which revealed that no @entity0 developed recurrence, and only one case resulted in mortality due to unassociated causes. It was found that @entity3 is a well-differentiated disease with low malignant potential and locally aggressive features, which seldom metastasizes to regional lymph nodes or distant regions. However, misdiagnosis may occur due to an incorrect biopsy. Favorable outcomes can be achieved by surgery, even without any adjuvant therapy, but @entity0 should be carefully followed up.

title: Diagnosis and treatment of XXXX .

answer: @entity3


abstract: BACKGROUND: In @entity0 affected by @entity4 deemed unsuitable for pancreatoduodenectomy, biliary diversion is the only proposable option. Defined goals of this treatment are: relief from @entity6 preventing its related complications, reduction of in-hospital stay and adequate control of @entity2 . Palliation can be obtained either by surgical or conservative procedures (endoscopic stenting or percutaneous treatment). Considering early complications' incidence, surgical approach has always been reserved for low surgical risk @entity0 with longer survival perspectives, while recently developed long-lasting patency stents enlarged mini-invasive application resort. Comparative studies on these therapeutic options favour the conservative one in respect of conventional open surgery, but data on minimally invasive surgery to pursue palliative aims are lacking. We present our six-years casuistic and results referring to laparoscopic biliary diversions. METHODS: We analyzed results obtained in distal biliary neoplastic obstruction management between December 2008 and November 2014. During this period, selected @entity0 considered unsuitable for pancreatoduodenectomy were scheduled to receive a laparoscopic biliary decompression. Perioperative variables and 30-days postoperative outcomes have been prospectively collected. RESULTS: In the six-years period, 12 @entity0 affected by distal biliary neoplastic obstruction were submitted to laparoscopic palliative bypass. Four procedures were proposed for @entity1 , one for advanced @entity1 and seven for @entity5 . Ten hepatico-jejunal bypasses and two choledochoduodenostomies have been performed. No conversions to open surgery were encountered in this series. Main operative time was 85 min, main @entity3 was 75 ml and main hospitalization was 4.5 days. According to Clavien Dindo Classification one class II and one class IIIb complications occurred. CONCLUSIONS: Although the restricted number of @entity0 , our results suggest that laparoscopic biliary bypass could be a valid option in managing @entity4 , resulting in low perioperative morbidity, effective long term palliation of symptoms and improved quality of life.

title: Laparoscopic perspectives for XXXX .

answer: @entity4


abstract: BACKGROUND: @entity0 is the most common @entity2 in @entity1 . @entity3 (PSA) is a marker of prostate gland malignancy, which has been considered in cases with @entity0 in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHODS: In this case-control study, ninety @entity1 with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with Histological grade and conditions of vascular and perinural invasion, status of @entity2 receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut-off point for total PSA to differentiate benign and malignant masses was 0.31 with sensitivity and specificity of 100%, 100% (area under the curve [AUC] =1, P < 0.001) and the best cut-off point for free PSA to differentiate benign and malignant masses was 0.19 with sensitivity and specificity of 100% and 100% (AUC = 1, P < 0.001). After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23    0.1 vs. 0.3    0.08, P < 0.001). CONCLUSIONS: Serum PSA level could be applied for differentiating benign and malignant breast masses.

title: Is Serum XXXX a Diagnostic Marker for Benign and Malignant @entity0 in @entity1 ?

answer: @entity3


abstract: BACKGROUND: @entity0 is the most common @entity2 in @entity1 . @entity3 (PSA) is a marker of prostate gland malignancy, which has been considered in cases with @entity0 in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHODS: In this case-control study, ninety @entity1 with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with Histological grade and conditions of vascular and perinural invasion, status of @entity2 receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut-off point for total PSA to differentiate benign and malignant masses was 0.31 with sensitivity and specificity of 100%, 100% (area under the curve [AUC] =1, P < 0.001) and the best cut-off point for free PSA to differentiate benign and malignant masses was 0.19 with sensitivity and specificity of 100% and 100% (AUC = 1, P < 0.001). After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23    0.1 vs. 0.3    0.08, P < 0.001). CONCLUSIONS: Serum PSA level could be applied for differentiating benign and malignant breast masses.

title: Is Serum @entity3 a Diagnostic Marker for Benign and Malignant XXXX in @entity1 ?

answer: @entity0


abstract: BACKGROUND: @entity0 is the most common @entity2 in @entity1 . @entity3 (PSA) is a marker of prostate gland malignancy, which has been considered in cases with @entity0 in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHODS: In this case-control study, ninety @entity1 with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with Histological grade and conditions of vascular and perinural invasion, status of @entity2 receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut-off point for total PSA to differentiate benign and malignant masses was 0.31 with sensitivity and specificity of 100%, 100% (area under the curve [AUC] =1, P < 0.001) and the best cut-off point for free PSA to differentiate benign and malignant masses was 0.19 with sensitivity and specificity of 100% and 100% (AUC = 1, P < 0.001). After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23    0.1 vs. 0.3    0.08, P < 0.001). CONCLUSIONS: Serum PSA level could be applied for differentiating benign and malignant breast masses.

title: Is Serum @entity3 a Diagnostic Marker for Benign and Malignant @entity0 in XXXX ?

answer: @entity1


abstract: OBJECTIVES: The objective was to explore which @entity0 characteristics are associated with repeat @entity2 ( @entity2 ) visitation within 30  days of @entity2 discharge for @entity0 presenting with @entity4 . METHODS: A retrospective, observational study was conducted at a single, @entity6 . A consecutive sample of adult @entity0 with a chief complaint of @entity4 from January 2010 through December 2010 who were discharged following @entity2 evaluation were included in the analysis. A logistic regression model was used to determine which @entity0 -level factors, including computed tomography (CT) utilization, were associated with the primary outcome of @entity2 revisit within 30  days. RESULTS: Of 80,619 total @entity2 @entity0 visits during the study period, 3,928 @entity2 discharges with a chief complaint of @entity4 were included. A total of 487 (12.4%) @entity0 revisited the @entity2 within 30  days. No deaths were recorded. CT imaging was associated with a lower 30-day revisit rate (odds ratio [OR]  = 0.69, 95% confidence interval [CI]  =  0.55 to 0.87) after controlling for multiple other @entity0 -level factors associated with revisits. Increasing age (OR  = 1.01, 95% CI  =  1.00 to 1.02), increasing triage @entity1 scores (OR  = 1.13, 95% CI  =  1.08 to 1.18), elevated triage heart rate (OR  = 1.42, 95% CI  =  1.07 to 1.89), low @entity5 levels (OR  = 1.56, 95% CI  =  1.07 to 2.23), and @entity3 (OR  = 1.42, 95% CI  =  1.04 to 1.95) were all associated with increased rate of return. CONCLUSIONS: Performance of an abdominal CT was associated with fewer 30-day revisits, suggesting that future measures of "imaging appropriateness" and " @entity2 overuse" consider downstream utilization of health care resources in addition to the index visit.

title: Abdominal Computed Tomography Utilization and 30-day Revisitation in Emergency Department @entity0 Presenting With XXXX .

answer: @entity4


abstract: OBJECTIVES: The objective was to explore which @entity0 characteristics are associated with repeat @entity2 ( @entity2 ) visitation within 30  days of @entity2 discharge for @entity0 presenting with @entity4 . METHODS: A retrospective, observational study was conducted at a single, @entity6 . A consecutive sample of adult @entity0 with a chief complaint of @entity4 from January 2010 through December 2010 who were discharged following @entity2 evaluation were included in the analysis. A logistic regression model was used to determine which @entity0 -level factors, including computed tomography (CT) utilization, were associated with the primary outcome of @entity2 revisit within 30  days. RESULTS: Of 80,619 total @entity2 @entity0 visits during the study period, 3,928 @entity2 discharges with a chief complaint of @entity4 were included. A total of 487 (12.4%) @entity0 revisited the @entity2 within 30  days. No deaths were recorded. CT imaging was associated with a lower 30-day revisit rate (odds ratio [OR]  = 0.69, 95% confidence interval [CI]  =  0.55 to 0.87) after controlling for multiple other @entity0 -level factors associated with revisits. Increasing age (OR  = 1.01, 95% CI  =  1.00 to 1.02), increasing triage @entity1 scores (OR  = 1.13, 95% CI  =  1.08 to 1.18), elevated triage heart rate (OR  = 1.42, 95% CI  =  1.07 to 1.89), low @entity5 levels (OR  = 1.56, 95% CI  =  1.07 to 2.23), and @entity3 (OR  = 1.42, 95% CI  =  1.04 to 1.95) were all associated with increased rate of return. CONCLUSIONS: Performance of an abdominal CT was associated with fewer 30-day revisits, suggesting that future measures of "imaging appropriateness" and " @entity2 overuse" consider downstream utilization of health care resources in addition to the index visit.

title: Abdominal Computed Tomography Utilization and 30-day Revisitation in Emergency Department XXXX Presenting With @entity4 .

answer: @entity0


abstract: PURPOSE OF THE STUDY: The study objective was to understand providers' perceptions regarding identifying and treating older adults with @entity3 , a common complication of @entity2 in @entity0 with @entity1 , in the pre-hospital and emergency department environments. DESIGN AND METHODS: The authors conducted structured focus group interviews with separate groups of emergency medical services staff, emergency nurses, and emergency physicians. Recordings of each session were transcribed, coded, and analyzed for themes with representative supporting quotations identified. RESULTS: Providers shared that the busy emergency department environment was the largest challenge to @entity3 recognition and treatment. When describing @entity3 , @entity0 frequently detailed hyperactive features of @entity3 , rather than hypoactive features. @entity0 shared that they employed no clear diagnostic strategy for identifying the condition and that they used heterogeneous approaches to treat the condition. To improve care for older adults with @entity3 , emergency nurses identified the need for more training around the management of the condition. Emergency medical services providers identified the need for more support in managing @entity4 @entity0 when in transport to the hospital and more guidance from emergency physicians on what information to collect from the @entity0 's home environment. Emergency physicians felt that @entity3 care would be improved if they could have baseline mental status data on their @entity0 and if they had access to a simple, accurate diagnostic tool for the condition. IMPLICATIONS: Emergency medical services providers, emergency nurses, and emergency physicians frequently encounter delirious @entity0 , but do not employ clear diagnostic strategies for identifying the condition and have varying levels of comfort in managing the condition. Clear steps should be taken to improve @entity3 care in the emergency department including the development of mechanisms to communicate @entity0 ' baseline mental status, the adoption of a systematized approach to recognizing @entity3 , and the institution of a standardized method to treat the condition when identified.

title: Emergency medical service, nursing, and physician providers' perspectives on XXXX identification and management.

answer: @entity3


abstract: UNASSIGNED: Several laboratories, including ours, have reported an overrepresentation of @entity9 ( @entity9 ) anomalies in @entity3 ( @entity3 ). How might this dysmorphology arise in a @entity1 ? Because the brain and face derive from shared embryologic primordia and morphogenetic forces, maldevelopmental processes may result in both @entity9 and @entity1 . Our approach is 2-pronged. First, we have employed, for the first time in the study of @entity2 , objective measures of @entity9 morphology that utilize an extensive normative database, permitting computation of standardized scores for each subject. Second, we have rendered these findings biologically interpretable by adopting principles of embryology in the analysis of dysmorphology. Dependent measures in this investigation focused on derivatives of specific @entity8 and were contrasted among probands with @entity6 , their first-degree relatives, and normal controls (NC). Subject groups included @entity0 with a diagnosis of @entity3 (N = 39) or @entity4 with @entity5 features (N = 32), their clinically unaffected relatives (N = 82 and N = 41, respectively), and NC (N = 95) subjects. Anomalies involving derivatives of frontonasal and mandibular @entity8 showed a clear association with @entity5 , as well as @entity7 in relatives in both diagnostic groups. In contrast, one class of @entity9 emerged only among @entity3 probands and their first-degree relatives: dysmorphology arising along the junction of the frontonasal and maxillary prominence derivatives, manifested as marked asymmetries. This class was not overrepresented among the BP @entity0 nor among their relatives, indicating that this dysmorphology appears to be specific to @entity3 and not a generalized feature of @entity5 . We discuss these findings in light of embryologic models that relate brain regions to specific @entity9 areas.

title: Quantitative Measures of Craniofacial Dysmorphology in a Family Study of @entity3 and XXXX .

answer: @entity4


abstract: UNASSIGNED: Several laboratories, including ours, have reported an overrepresentation of @entity9 ( @entity9 ) anomalies in @entity3 ( @entity3 ). How might this dysmorphology arise in a @entity1 ? Because the brain and face derive from shared embryologic primordia and morphogenetic forces, maldevelopmental processes may result in both @entity9 and @entity1 . Our approach is 2-pronged. First, we have employed, for the first time in the study of @entity2 , objective measures of @entity9 morphology that utilize an extensive normative database, permitting computation of standardized scores for each subject. Second, we have rendered these findings biologically interpretable by adopting principles of embryology in the analysis of dysmorphology. Dependent measures in this investigation focused on derivatives of specific @entity8 and were contrasted among probands with @entity6 , their first-degree relatives, and normal controls (NC). Subject groups included @entity0 with a diagnosis of @entity3 (N = 39) or @entity4 with @entity5 features (N = 32), their clinically unaffected relatives (N = 82 and N = 41, respectively), and NC (N = 95) subjects. Anomalies involving derivatives of frontonasal and mandibular @entity8 showed a clear association with @entity5 , as well as @entity7 in relatives in both diagnostic groups. In contrast, one class of @entity9 emerged only among @entity3 probands and their first-degree relatives: dysmorphology arising along the junction of the frontonasal and maxillary prominence derivatives, manifested as marked asymmetries. This class was not overrepresented among the BP @entity0 nor among their relatives, indicating that this dysmorphology appears to be specific to @entity3 and not a generalized feature of @entity5 . We discuss these findings in light of embryologic models that relate brain regions to specific @entity9 areas.

title: Quantitative Measures of Craniofacial Dysmorphology in a Family Study of XXXX and @entity4 .

answer: @entity3


abstract: UNASSIGNED: @entity4 is the most common @entity0 fungal pathogen, yet is a normal commensal resident of the @entity0 gut. @entity3 levels in the gut are much higher than in air, and it is known that elevated @entity3 concentration promotes @entity4 cells to undergo a phenotypic switch from white to opaque phase. Wor1, the master regulator of opaque cell formation, is required for both the white-to-opaque transition and opaque maintenance. To elucidate the regulatory mechanism of Wor1, we set out to identify Wor1-interacting proteins using a yeast two-hybrid screen. A SUMO E3 ligase named Wos1 (Wor1 SUMO-ligase 1) was identified to interact with Wor1 and regulate Wor1 sumoylation. WOS1 expression is up-regulated in response to high @entity3 , and the induction by @entity3 is dependent on the transcription factor Flo8. Under high @entity3 conditions, Wos1 is required for the white-to-opaque switch and acts downstream of Flo8. At atmospheric @entity3 levels, over-expression of Wos1 enhances Wor1 sumoylation and promotes the white-to-opaque switch. Wor1 is found to be sumoylated at @entity2 385, and loss of this mark by point mutation leads to a defect in @entity3 -mediated opaque cell induction. Together our genetic and biological data show that Wos1-mediated Wor1 sumoylation contributes to the regulation of @entity3 -induced @entity1 as well as heritable maintenance of the opaque cell type.

title: Sumoylation of Wor1 by a novel SUMO E3 ligase controls cell fate in XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate the effectiveness of biopsychosocial @entity3 ( @entity3 ) delivered by practice nurses in routine @entity1 care. DESIGN: A pragmatic cluster-randomised controlled trial within a hybrid effectiveness-implementation study design. Practice nurses were cluster-randomised. SETTING: A regional care group in the Netherlands consisting of 77 family practices. The study involved practice nurses (n=40) providing care to approximately 4000 @entity0 with @entity1 . @entity0 : @entity0 with @entity2 2 @entity1 (n=264) selected by a self-administered questionnaire aimed at measuring emotional distress and @entity1 -related reduced daily functioning. INTERVENTION: Practice nurses in the intervention arm (n=19) were trained to integrate @entity3 into their routine consultations. @entity3 included detection of @entity0 with emotional distress and reduced daily functioning, and supporting them when needed through problem solving and reattribution techniques. Practice nurses in the control arm (n=21) provided usual care. MAIN OUTCOME MEASURES: The primary outcome measure was a dichotomised score on a Visual Analogue Scale that measured the perceived effect of @entity1 on daily functioning. Secondary measures included @entity0 ' @entity1 , quality of life, autonomy and participation, self-efficacy, self-management and glycaemic control. Outcomes were measured at baseline and at 4-month and 12-month follow-ups. RESULTS: Only 16 of the 117 @entity0 in the intervention arm (14%) who were found eligible by the posted research-driven screening questionnaire were detected by their practice nurses. Extra consultations for the self-management support were delivered to only 11 study @entity0 . In the control arm, 147 @entity0 received usual care. Multilevel analyses showed no significant differences in outcomes between the intervention and control arms. CONCLUSIONS: @entity3 in its present form was not effective. The research-driven screening to select trial @entity0 appeared to be inconsistent with nurse-led detection in routine practice. Adequate follow-up moments need to be built in to overcome barriers resulting from tension between the implementation and effectiveness parts of hybrid studies. TRIAL REGISTRATION NUMBER: Current Controlled Trials NTR2764.

title: Lessons learnt from a cluster-randomised trial evaluating the effectiveness of @entity3 ( XXXX ) delivered by practice nurses in routine @entity1 care.

answer: @entity3


abstract: OBJECTIVE: To evaluate the effectiveness of biopsychosocial @entity3 ( @entity3 ) delivered by practice nurses in routine @entity1 care. DESIGN: A pragmatic cluster-randomised controlled trial within a hybrid effectiveness-implementation study design. Practice nurses were cluster-randomised. SETTING: A regional care group in the Netherlands consisting of 77 family practices. The study involved practice nurses (n=40) providing care to approximately 4000 @entity0 with @entity1 . @entity0 : @entity0 with @entity2 2 @entity1 (n=264) selected by a self-administered questionnaire aimed at measuring emotional distress and @entity1 -related reduced daily functioning. INTERVENTION: Practice nurses in the intervention arm (n=19) were trained to integrate @entity3 into their routine consultations. @entity3 included detection of @entity0 with emotional distress and reduced daily functioning, and supporting them when needed through problem solving and reattribution techniques. Practice nurses in the control arm (n=21) provided usual care. MAIN OUTCOME MEASURES: The primary outcome measure was a dichotomised score on a Visual Analogue Scale that measured the perceived effect of @entity1 on daily functioning. Secondary measures included @entity0 ' @entity1 , quality of life, autonomy and participation, self-efficacy, self-management and glycaemic control. Outcomes were measured at baseline and at 4-month and 12-month follow-ups. RESULTS: Only 16 of the 117 @entity0 in the intervention arm (14%) who were found eligible by the posted research-driven screening questionnaire were detected by their practice nurses. Extra consultations for the self-management support were delivered to only 11 study @entity0 . In the control arm, 147 @entity0 received usual care. Multilevel analyses showed no significant differences in outcomes between the intervention and control arms. CONCLUSIONS: @entity3 in its present form was not effective. The research-driven screening to select trial @entity0 appeared to be inconsistent with nurse-led detection in routine practice. Adequate follow-up moments need to be built in to overcome barriers resulting from tension between the implementation and effectiveness parts of hybrid studies. TRIAL REGISTRATION NUMBER: Current Controlled Trials NTR2764.

title: Lessons learnt from a cluster-randomised trial evaluating the effectiveness of XXXX ( @entity3 ) delivered by practice nurses in routine @entity1 care.

answer: @entity3


abstract: OBJECTIVE: To evaluate the effectiveness of biopsychosocial @entity3 ( @entity3 ) delivered by practice nurses in routine @entity1 care. DESIGN: A pragmatic cluster-randomised controlled trial within a hybrid effectiveness-implementation study design. Practice nurses were cluster-randomised. SETTING: A regional care group in the Netherlands consisting of 77 family practices. The study involved practice nurses (n=40) providing care to approximately 4000 @entity0 with @entity1 . @entity0 : @entity0 with @entity2 2 @entity1 (n=264) selected by a self-administered questionnaire aimed at measuring emotional distress and @entity1 -related reduced daily functioning. INTERVENTION: Practice nurses in the intervention arm (n=19) were trained to integrate @entity3 into their routine consultations. @entity3 included detection of @entity0 with emotional distress and reduced daily functioning, and supporting them when needed through problem solving and reattribution techniques. Practice nurses in the control arm (n=21) provided usual care. MAIN OUTCOME MEASURES: The primary outcome measure was a dichotomised score on a Visual Analogue Scale that measured the perceived effect of @entity1 on daily functioning. Secondary measures included @entity0 ' @entity1 , quality of life, autonomy and participation, self-efficacy, self-management and glycaemic control. Outcomes were measured at baseline and at 4-month and 12-month follow-ups. RESULTS: Only 16 of the 117 @entity0 in the intervention arm (14%) who were found eligible by the posted research-driven screening questionnaire were detected by their practice nurses. Extra consultations for the self-management support were delivered to only 11 study @entity0 . In the control arm, 147 @entity0 received usual care. Multilevel analyses showed no significant differences in outcomes between the intervention and control arms. CONCLUSIONS: @entity3 in its present form was not effective. The research-driven screening to select trial @entity0 appeared to be inconsistent with nurse-led detection in routine practice. Adequate follow-up moments need to be built in to overcome barriers resulting from tension between the implementation and effectiveness parts of hybrid studies. TRIAL REGISTRATION NUMBER: Current Controlled Trials NTR2764.

title: Lessons learnt from a cluster-randomised trial evaluating the effectiveness of @entity3 ( @entity3 ) delivered by practice nurses in routine XXXX care.

answer: @entity1


abstract: PURPOSE: We report a case of a large three-level @entity4 infiltrating the adjacent aorta. This is the first case in which a combined modified three-level en bloc corpectomy with resection and replacement of the adjacent aorta was successful as a part of interdisciplinary curative treatment. METHODS: Case report. RESULTS: The surgical procedure was performed as a two-step treatment. A heart lung machine (HLM) was not used, in order to avoid cerebral and spinal @entity3 and to decrease the risk of @entity1 metastases. Instead, a bypass from the left subclavian artery the distal descending aorta was used. We modified the en bloc corpectomy procedure, leaving a dorsal segment of the vertebral bodies to enable rapid surgery. The procedure was successful and the en bloc resection of the vertebral body with aortal resection could be achieved. Except for pallhypesthesia in the left dermatomes Th7-Th10, the @entity0 does not have any postoperative @entity2 . CONCLUSION: Combined corpectomy with aortic replacement should be considered as a reasonable option in the curative treatment of @entity4 with consideration of the immense surgical risks. The use of an HLM is not necessary, especially considering the inherent risk of @entity1 metastases. Modified corpectomy leaving a dorsal vertebral body segment was considered a reasonable variation since @entity1 -free margins could still be expected.

title: Combined modified en bloc corpectomy with replacement of the aorta in curative interdisciplinary treatment of a large XXXX infiltrating the aorta.

answer: @entity4


abstract: CLINICAL PROBLEM: We diagnosed 8 @entity0 with late-stage @entity3 ( @entity3 ) between 1 and 14 years of age. Five @entity0 complained of symptoms related to @entity4 . The other 3 @entity0 required urethrocystoscopy for other reasons ( @entity6 fistulae, difficulty with catheterisation and high-grade @entity7 [ @entity7 ]). A second review of the first 2 @entity0 ' medical history showed @entity2 . All @entity0 underwent preoperative ultrasonography: 3 @entity0 had normal results and 5 had @entity1 . The diagnosis was reached through voiding cystourethrogram (VCUG), and 4 @entity0 underwent urodynamic studies. The diagnosis was confirmed by urethrocystoscopy, performing valve electrofulguration. We performed urethrocystoscopy during the check-ups at 3-6 weeks and observed no @entity5 . The symptoms disappeared for all @entity0 after 20 months of follow-up. The @entity0 with @entity7 was cured. The ultrasounds showed no progression of the renal involvement and showed improvement in the vesical involvement. The velocimetries during check-ups presented curves within normal ranges. DISCUSSION: Most @entity0 with @entity3 are diagnosed through ultrasound during the neonatal period. Some @entity0 present @entity3 at later ages with diverse symptoms, which impedes its diagnosis. We should suspect @entity3 in male @entity0 with symptoms of @entity4 , either when they have normal or pathological results from ultrasounds or VCUG. We recommend performing urethrocystoscopy to rule out @entity8 .

title: Late diagnosis of XXXX .

answer: @entity3


abstract: AIMS: Retention in @entity1 maintenance treatment (MMT) for 1year is associated with positive outcomes including opioid abstinence, however, most studies have not investigated gender differences. We hypothesized that predictors of retention and opioid abstinence would differ between @entity0 and @entity0 , and aimed to determine which factors best predict retention and abstinence for each gender. METHODS: Data were available for 290 @entity0 (173M, 117F) admitted to outpatient MMT. Regression analyses, stratified by gender, were conducted to identify unique predictors of MMT retention (<1 vs. >1year) and opioid abstinence rate (proportion of opioid-free urine samples up to 1year retention). RESULTS: Gender did not significantly predict treatment retention (mean=231days, 39% retained >1year) or opioid abstinence (49% overall). For males, significant predictors of >1-year retention were urine samples negative for opioids (odds ratio [OR]=6.67) and cannabinoids (OR=5.00) during the first month, and not @entity2 dependent (OR=2.70). Significant predictors of higher long-term opioid abstinence were first-month urine samples negative for opioids and @entity2 metabolites. For females, significant predictors of >1-year retention were first-month urine samples negative for @entity2 metabolites (OR=4.00) and cannabinoids (OR=9.26), and no history of sexual victimization (OR=3.03). The only significant predictor of higher opioid abstinence rate was first-month opioid-free urine samples. CONCLUSIONS: These findings indicate gender-specific predictors of MMT retention and opioid abstinence. Future studies on MMT outcomes should examine each gender separately, and consider unique pathways by which females and males adhere to, and benefit from MMT.

title: Gender-specific predictors of retention and opioid abstinence during XXXX maintenance treatment.

answer: @entity1


abstract: OBJECTIVE: To test if @entity3 / @entity1 electronic decision support in primary care improves management. METHODS: Multicenter, single-blind, parallel-group, cluster randomized, controlled trial comparing @entity3 / @entity1 electronic decision support guided management with usual care. Main outcomes were guideline adherence and 90-day @entity1 risk. Secondary outcomes were cerebrovascular/vascular/ @entity2 /adverse events, cost, and user feedback. Main analysis was logistic regression with a normal random effect for clusters using a generalized linear mixed model. RESULTS: Twenty-nine clinics were randomized to intervention, 27 to control, recruiting 172 and 119 eligible @entity0 . More intervention @entity0 received guideline-adherent care (131/172; 76.2%) than control @entity0 (49/119; 41.2%) (adjusted odds ratio [OR] 4.57; 95% confidence interval [CI] 2.39-8.71; p < 0.001). Ninety-day @entity1 occurred in 2/172 (1.2%) intervention and 5/119 (4.2%) control @entity0 (OR 0.27; 95% CI 0.05-1.41; p = 0.098). Ninety-day @entity3 or @entity1 occurrence was lower in the intervention group, 4/172 (2.3%) compared to 10/119 (8.5%) control (adjusted OR 0.26; 95% CI 0.70-0.97; p = 0.045). Fewer vascular events/ @entity2 occurred in intervention, 6/172 (3.5%), than in control @entity0 , 14/119 (11.9%) (adjusted OR 0.27; 95% CI 0.09-0.78; p = 0.016). Treatment cost ratio of 0.65 (95% CI 0.47-0.91; p = 0.013) favored the intervention without increased adverse events. Clinician feedback was positive. CONCLUSION: Primary care use of the @entity3 / @entity1 electronic decision support tool improves guideline adherence, safely reduces treatment cost, achieves positive user feedback, and may reduce cerebrovascular and vascular event risk following @entity3 / @entity1 . CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that a primary care electronic decision support tool improves guideline adherence and might reduce 90-day @entity1 risk.

title: Cluster randomized controlled trial of XXXX electronic decision support in primary care.

answer: @entity3


abstract: BACKGROUND: Joint-preserving, realignment surgical procedures have gained increasing popularity as treatment of asymmetric early- and mid-stage @entity3 . The aim of the present study was to quantify bilateral gait biomechanics in @entity0 who underwent ankle realignment surgery by supramalleolar osteotomies. METHODS: Eight @entity0 , a minimum of 7 years after realignment surgery, and 8 healthy controls were included in this study. Three-dimensional instrumented gait analysis was used to assess spatiotemporal parameters, bilateral joint angles, and moments. Furthermore, a clinical evaluation on @entity1 , ankle function, and quality of life was performed. RESULTS: Compared with the healthy controls, the @entity0 walked more slowly, had a smaller sagittal hindfoot range of motion on their affected leg, and had a lower peak ankle dorsiflexion moment (P < .05). There were no significant differences compared with controls for the ranges of motion in the foot segments of the nonaffected foot and for the knee and @entity2 and peak moments of both legs. Additionally, @entity0 and controls did not differ in the quality of life score. However, in the @entity1 subscore, the @entity0 reported significantly more @entity1 than the healthy @entity0 . CONCLUSION: Despite different gait biomechanics of the affected foot after ankle realignment surgery, the quality of life for @entity0 was comparable to that of healthy controls. Therefore, supramalleolar osteotomies should be considered as a promising treatment option in @entity0 with asymmetric non-end-stage @entity3 . LEVEL OF EVIDENCE: Prognostic level III, comparative study.

title: Mid- to Long-term Clinical Outcome and Gait Biomechanics After Realignment Surgery in Asymmetric XXXX .

answer: @entity3


abstract: AIM: Even though numerous studies have focused on the effects of self-stigma on @entity0 with @entity1 , little is known about self-stigma of @entity0 with @entity2 ( @entity2 ). In this study, a self-administered scale of self-stigmatising attitudes of @entity0 with @entity2 and @entity1 was used to explore these attitudes, examine the potential differences between the two groups and study the factors that influence stigma within groups. METHODS: Self-stigma of 120 @entity0 with @entity1 and @entity2 was assessed with the Self-stigma Questionnaire (SSQ) and the @entity3 ( @entity3 ). Presence of clinical symptoms, overall functioning and level of self-esteem were also evaluated. RESULTS: Self-stigma is present in both groups but differs in its intensity. @entity0 with @entity2 experience self-stigma in a lesser degree without affecting their social life or overall functioning. @entity0 with @entity1 adopt more intense self-stigmatising attitudes leading to social exclusion and lower level of overall functioning. LIMITATIONS: The results are limited by the small sample size, whereas the inclusion of other questionnaires would broaden our insight to self-stigma. CONCLUSIONS: Self-stigma has a direct effect on overall functioning of @entity0 with @entity2 and @entity1 tampering the clinical outcome of therapeutic interventions. Therefore, it should be incorporated in every treatment plan and be addressed as a clinical symptom of the @entity3 .

title: XXXX and self-stigma: A comparison with @entity1 .

answer: @entity2


abstract: AIM: Even though numerous studies have focused on the effects of self-stigma on @entity0 with @entity1 , little is known about self-stigma of @entity0 with @entity2 ( @entity2 ). In this study, a self-administered scale of self-stigmatising attitudes of @entity0 with @entity2 and @entity1 was used to explore these attitudes, examine the potential differences between the two groups and study the factors that influence stigma within groups. METHODS: Self-stigma of 120 @entity0 with @entity1 and @entity2 was assessed with the Self-stigma Questionnaire (SSQ) and the @entity3 ( @entity3 ). Presence of clinical symptoms, overall functioning and level of self-esteem were also evaluated. RESULTS: Self-stigma is present in both groups but differs in its intensity. @entity0 with @entity2 experience self-stigma in a lesser degree without affecting their social life or overall functioning. @entity0 with @entity1 adopt more intense self-stigmatising attitudes leading to social exclusion and lower level of overall functioning. LIMITATIONS: The results are limited by the small sample size, whereas the inclusion of other questionnaires would broaden our insight to self-stigma. CONCLUSIONS: Self-stigma has a direct effect on overall functioning of @entity0 with @entity2 and @entity1 tampering the clinical outcome of therapeutic interventions. Therefore, it should be incorporated in every treatment plan and be addressed as a clinical symptom of the @entity3 .

title: @entity2 and self-stigma: A comparison with XXXX .

answer: @entity1


abstract: UNASSIGNED: The association between dialysis vascular @entity1 and the risk of developing major adverse cardiovascular events (MACE) in hemodialysis @entity0 is unclear and has not yet been investigated. We analyzed data from the National Health Insurance Research Database of Taiwan to quantify this association. Adopting a case-control design nested within a cohort of @entity0 who received hemodialysis from 2001 to 2010, we identified 9711 incident cases of MACE during the stage of stable maintenance dialysis and 19,422 randomly selected controls matched to cases on age, gender, and duration of dialysis. Events of vascular @entity1 in the 6-month period before the date of MACE onset (ie, index date) for cases and before index dates for controls were evaluated retrospectively. The presence of vascular @entity1 was associated with a 1.385-fold higher odds of developing MACE as estimated from the logistic regression analysis. This represents a significantly increased adjusted odds ratio (OR) at 1.268 (95% confidence interval [CI]=1.186-1.355) after adjustment for comorbidities and calendar years of initiating dialysis. We also noted a significant exposure-response trend (P<0.001) between the frequency of vascular @entity1 and MACE, with the greatest risk (adjusted OR=1.840, 95% CI=1.549-2.186) noted in @entity0 with >= 3 vascular access events. We concluded that dialysis vascular @entity1 was significantly associated with an increased risk of MACE. Hence, vascular access failure can be an early sign for MACE in @entity0 receiving maintenance hemodialysis. Active monitoring and treatment of cardiovascular risk factors and related diseases, not merely managing vascular @entity1 , would be required to reduce the risk of MACE.

title: Association Between Vascular Access Dysfunction and Subsequent Major Adverse Cardiovascular Events in XXXX on Hemodialysis: A Population-Based Nested Case-Control Study.

answer: @entity0


abstract: UNASSIGNED: The aim of this study was to determine the levels of @entity8 ( @entity8 ) and @entity9 ( @entity9 ) in @entity0 with @entity6 and its relationship with joint inflammatory data and/or with @entity5 ( @entity5 ) variables, during 1 year follow-up.Forty-one @entity0 (40 males) with @entity6 diagnosis, attending for the first time to a rheumatology department, were included. Evaluations were performed baseline, at 6 and 12 months. Variables included the following: demographic, clinical and laboratory data related to @entity6 and associated diseases. @entity8 and @entity9 determinations by the ELISA method were performed in frozen serum from each visit. The pharmacological and no-pharmacological treatment for @entity6 and associated diseases was individualized for each @entity0 according to published guidelines. Statistical analysis included Mann-Whitney U test, Fisher test, x, ANOVA, Cochran Q, Pearson and Spearman correlation tests, as well as linear regression.In the baseline evaluation, 29.2% had @entity5 ( @entity12 66%, @entity2 44% and @entity1 37%); @entity0 with @entity5 had higher @entity11 (CRP) levels [34.1  28.6 vs. 12.2  11.2mg/dL, P=0.033]. Although not significant, also had higher @entity8 and lower @entity9 levels (3.2  3.0 vs. 1.9  1.2ng/mL, P=0.142 and 40.5  26.8 vs. 38.0  24.9ng/mL, P=0.877, respectively). During follow-up, our @entity0 had significant improvement in serum @entity7 (sUA) levels and variables evaluating @entity3 (P  <= 0.05). @entity5 tended to persist or even worsen during the monitoring period: significant increase in total @entity4 (P=0.004), tendency to higher @entity10 (P=0.883) and slight improvement in glycaemia (P=0.052). @entity8 values increased significantly during follow-up (P=0.001) while @entity9 levels diminished slightly (P=0.317). Neither @entity8 nor @entity9 values showed important correlation (r>0.5) with metabolic variables or joint swelling.This study suggests that in @entity0 with @entity6 , concentrations of @entity8 and @entity9 are more in line with the metabolic state than with clinical disease activity.

title: A Prospective Follow-Up of Adipocytokines in Cohort @entity0 With Gout: Association With XXXX But Not With Clinical Inflammatory Findings: Strobe-Compliant Article.

answer: @entity5


abstract: UNASSIGNED: The aim of this study was to determine the levels of @entity8 ( @entity8 ) and @entity9 ( @entity9 ) in @entity0 with @entity6 and its relationship with joint inflammatory data and/or with @entity5 ( @entity5 ) variables, during 1 year follow-up.Forty-one @entity0 (40 males) with @entity6 diagnosis, attending for the first time to a rheumatology department, were included. Evaluations were performed baseline, at 6 and 12 months. Variables included the following: demographic, clinical and laboratory data related to @entity6 and associated diseases. @entity8 and @entity9 determinations by the ELISA method were performed in frozen serum from each visit. The pharmacological and no-pharmacological treatment for @entity6 and associated diseases was individualized for each @entity0 according to published guidelines. Statistical analysis included Mann-Whitney U test, Fisher test, x, ANOVA, Cochran Q, Pearson and Spearman correlation tests, as well as linear regression.In the baseline evaluation, 29.2% had @entity5 ( @entity12 66%, @entity2 44% and @entity1 37%); @entity0 with @entity5 had higher @entity11 (CRP) levels [34.1  28.6 vs. 12.2  11.2mg/dL, P=0.033]. Although not significant, also had higher @entity8 and lower @entity9 levels (3.2  3.0 vs. 1.9  1.2ng/mL, P=0.142 and 40.5  26.8 vs. 38.0  24.9ng/mL, P=0.877, respectively). During follow-up, our @entity0 had significant improvement in serum @entity7 (sUA) levels and variables evaluating @entity3 (P  <= 0.05). @entity5 tended to persist or even worsen during the monitoring period: significant increase in total @entity4 (P=0.004), tendency to higher @entity10 (P=0.883) and slight improvement in glycaemia (P=0.052). @entity8 values increased significantly during follow-up (P=0.001) while @entity9 levels diminished slightly (P=0.317). Neither @entity8 nor @entity9 values showed important correlation (r>0.5) with metabolic variables or joint swelling.This study suggests that in @entity0 with @entity6 , concentrations of @entity8 and @entity9 are more in line with the metabolic state than with clinical disease activity.

title: A Prospective Follow-Up of Adipocytokines in Cohort XXXX With Gout: Association With @entity5 But Not With Clinical Inflammatory Findings: Strobe-Compliant Article.

answer: @entity0


abstract: Female @entity5 @entity0 were mated with @entity5 X T/ + F1 males that were heterozygous for the @entity3 lethal gene or were +/+. Fetuses from @entity5 X +/+ matings were normal when observed on gestation Day 17 (plug day = Day 0). Those from the @entity5 X T/+ cross exhibited the expected 1:1 ratio of short:normal tail lengths, but 10% of these fetuses were tailless, apparently due to factors in the @entity5 genotype that increased the expressivity of the T-gene with regard to reduction of tail length. Additional @entity5 females were mated with @entity5 X tw18/+ F1 males. Fetuses from the @entity5 X tw18/+ matings were normal. @entity5 females carrying @entity5 X +/+, @entity5 X T/+, or @entity5 X tw18/+ litters were injected ip on gestation Day 9 with 30 mg/kg @entity4 or were untreated. @entity4 was teratogenic for litters from all three crosses. Polydactyly, @entity6 , and a variety of @entity2 were observed. Gross @entity1 were increased in treated @entity5 X T/ + or tw18/+ litters in comparison with @entity5 X +/+ litters, as were nonvertebral skeletal defects in @entity5 X tw18/+ litters. Prenatal mortality was also greater in treated mutant-containing litters than in +/+ litters, and fetal weights were similarly decreased in treated @entity5 X tw18/+ litters. The incidence of taillessness was also higher in treated (26%) than in control (10%) @entity5 X T/+ litters. Thus both the T and tw18 alleles appear to have enhanced the teratogenicity of @entity4 , and the inhibitor may have increased the expressivity of T.

title: Interactions between XXXX and T-locus alleles during @entity0 embryogenesis.

answer: @entity4


abstract: Female @entity5 @entity0 were mated with @entity5 X T/ + F1 males that were heterozygous for the @entity3 lethal gene or were +/+. Fetuses from @entity5 X +/+ matings were normal when observed on gestation Day 17 (plug day = Day 0). Those from the @entity5 X T/+ cross exhibited the expected 1:1 ratio of short:normal tail lengths, but 10% of these fetuses were tailless, apparently due to factors in the @entity5 genotype that increased the expressivity of the T-gene with regard to reduction of tail length. Additional @entity5 females were mated with @entity5 X tw18/+ F1 males. Fetuses from the @entity5 X tw18/+ matings were normal. @entity5 females carrying @entity5 X +/+, @entity5 X T/+, or @entity5 X tw18/+ litters were injected ip on gestation Day 9 with 30 mg/kg @entity4 or were untreated. @entity4 was teratogenic for litters from all three crosses. Polydactyly, @entity6 , and a variety of @entity2 were observed. Gross @entity1 were increased in treated @entity5 X T/ + or tw18/+ litters in comparison with @entity5 X +/+ litters, as were nonvertebral skeletal defects in @entity5 X tw18/+ litters. Prenatal mortality was also greater in treated mutant-containing litters than in +/+ litters, and fetal weights were similarly decreased in treated @entity5 X tw18/+ litters. The incidence of taillessness was also higher in treated (26%) than in control (10%) @entity5 X T/+ litters. Thus both the T and tw18 alleles appear to have enhanced the teratogenicity of @entity4 , and the inhibitor may have increased the expressivity of T.

title: Interactions between @entity4 and T-locus alleles during XXXX embryogenesis.

answer: @entity0


abstract: Background. Even if various pathophysiological events have been proposed as explanations, the putative cause of @entity3 remains unclear. Objectives. To investigate and to reveal associations (if any) between the main iron-related gene variants and @entity2 . Study Design. Case-control study. Materials and Methods. A total of 200 sudden @entity2 @entity0 (median age 63.65 years; range 10-92) were compared with 400 healthy control subjects. The following genetic variants were investigated: the polymorphism c.-8CG in the promoter of the ferroportin gene ( @entity9 ; @entity9 ), the two isoforms @entity4 ( @entity11 ) of the @entity1 protein (TF), the amino acidic substitutions @entity6 and @entity8 in the @entity5 protein ( @entity7 ), and the polymorphism c.-582AG in the promoter of the @entity10 gene, which encodes the protein hepcidin ( @entity10 ). Results. The homozygous genotype c.-8GG of the @entity9 gene revealed an OR for ISSNHL risk of 4.27 (CI 95%, 2.65-6.89; P = 0.001), being overrepresented among cases. Conclusions. Our study indicates that the homozygous genotype @entity9 -8GG was significantly associated with increased risk of developing @entity3 . These findings suggest new research should be conducted in the field of iron homeostasis in the inner ear.

title: Sudden XXXX and polymorphisms in iron homeostasis genes: new insights from a case-control study.

answer: @entity2


abstract: UNASSIGNED: Early excessive @entity2 is positively associated with @entity1 , and yet the effect of @entity2 during specific periods and the impact of @entity0 feeding practices are debated. The objective of the present study was to examine the impact of @entity2 in periods of early childhood on body composition at 3 years, and whether @entity0 feeding modified the relationship between early growth and body composition at 3 years. We studied 233 @entity0 from the prospective cohort study, SKOT (in Danish: Sm  b  rns Kost og Trivsel). Birth weight z-scores (BWZ) and change in weight-for-age z-scores (WAZ) from 0 to 5, 5 to 9, 9 to 18 and 18 to 36 months were analysed for relations with body composition (anthropometry and bioelectrical impedance) at 3 years by multivariate regression analysis. BWZ and change in WAZ from 0 to 5 months were positively associated with BMI, fat mass index (FMI) and fat-free mass index (FFMI) at 3 years. Full breastfeeding for 6 months (compared to less than 1 month) eliminated the effect of early growth (P=  0  01). Full breastfeeding for 6 months (compared to less than 1 month) also eliminated the positive relation between BWZ and FMI (P=  0  009). No effect modification of @entity0 feeding was found for FFMI. In conclusion, high birth weight and rapid growth from 0 to 5 months were associated with increased FMI and FFMI at 3 years. Longer duration of full breastfeeding reduced the effect of birth weight and early @entity2 on fat mass.

title: The impact of early growth patterns and XXXX feeding on body composition at 3 years of age.

answer: @entity0


abstract: BACKGROUND: Prevention of secondary @entity3 is a key component of acute management of @entity0 with severe @entity2 ( @entity2 ). Haemoglobin concentration may have an impact on optimization of cerebral oxygenation. @entity0 with @entity2 may best be served by an organized @entity1 service. The objective is to determine if haemoglobin concentration or dedicated @entity1 admission has an impact on outcomes after severe @entity2 . METHODS: This study retrospectively analysed consecutive @entity0 with severe @entity2 admitted to a level-I @entity1 centre over 3 years. @entity0 <16 years-old and with length of stay (LOS) <24 hours were excluded. Data were collected on demographics; injury severity; LOS; admission service; survival to discharge; and haemoglobin levels from hospital days 1-7. Data were also collected on number of transfusions of packed red blood cells. The sample was stratified based on admission service and survival to discharge. RESULTS: Of 147 @entity0 (age   =   54.1        3.7 years), overall mortality rate was 15.4% (n   =   23). Overall, non-survivors had lower daily and 7-day mean haemoglobin levels (10.7        0.9 vs. 12.9        0.4   g   dL(-1), p   <   0.001). Non-surgical admissions had lower haemoglobin levels and a higher mortality rate (28.9% vs. 12.2%, p   <   0.001) compared to dedicated @entity1 admissions. CONCLUSIONS: Among @entity0 with severe @entity2 , higher haemoglobin levels and maintenance as a dedicated @entity1 admission are associated with higher survival to discharge.

title: Higher haemoglobin levels and dedicated @entity1 admission are associated with survival after severe XXXX .

answer: @entity2


abstract: BACKGROUND: Prevention of secondary @entity3 is a key component of acute management of @entity0 with severe @entity2 ( @entity2 ). Haemoglobin concentration may have an impact on optimization of cerebral oxygenation. @entity0 with @entity2 may best be served by an organized @entity1 service. The objective is to determine if haemoglobin concentration or dedicated @entity1 admission has an impact on outcomes after severe @entity2 . METHODS: This study retrospectively analysed consecutive @entity0 with severe @entity2 admitted to a level-I @entity1 centre over 3 years. @entity0 <16 years-old and with length of stay (LOS) <24 hours were excluded. Data were collected on demographics; injury severity; LOS; admission service; survival to discharge; and haemoglobin levels from hospital days 1-7. Data were also collected on number of transfusions of packed red blood cells. The sample was stratified based on admission service and survival to discharge. RESULTS: Of 147 @entity0 (age   =   54.1        3.7 years), overall mortality rate was 15.4% (n   =   23). Overall, non-survivors had lower daily and 7-day mean haemoglobin levels (10.7        0.9 vs. 12.9        0.4   g   dL(-1), p   <   0.001). Non-surgical admissions had lower haemoglobin levels and a higher mortality rate (28.9% vs. 12.2%, p   <   0.001) compared to dedicated @entity1 admissions. CONCLUSIONS: Among @entity0 with severe @entity2 , higher haemoglobin levels and maintenance as a dedicated @entity1 admission are associated with higher survival to discharge.

title: Higher haemoglobin levels and dedicated XXXX admission are associated with survival after severe @entity2 .

answer: @entity1


abstract: UNASSIGNED: @entity1 ( @entity1 ) is one of the natural mechanisms of @entity2 for limiting the spread of @entity0 and @entity4 parasitic mite. Objective of our study was to measure @entity1 of @entity2 unicolor colonies (N = 403) from three geographic regions (one infested and two free of @entity4 ) in Madagascar. The pin-killing method was used for evaluation of the @entity1 . Responses were measured from 3 h 30 min to 7 h after perforation of the cells. Colonies were very effective in detecting perforated cells. In the first 4 h, on average, they detected at least 50% of the pin-killed brood. Six hours after cell perforation, colonies tested (N = 91) showed a wide range of uncapped (0 to 100%) and cleaned cells (0 to 82%). Global distribution of the rate of cleaned cells at 6 h was multimodal and @entity3 responses could be split in three classes. Colonies from the three regions showed a significant difference in @entity1 responses. Three hypotheses (geographic, genetic traits, presence of @entity4 ) are further discussed to explain variability of @entity1 responses among the regions. Levels of @entity1 efficiency of A. mellifera unicolor colonies are among the greatest levels reported for A. mellifera subspecies. Presence of highly @entity3 colonies is a great opportunity for future breeding program in selection for @entity1 .

title: Assessing @entity3 behavior of XXXX unicolor (Hymenoptera: Apidae), the endemic @entity2 from Madagascar.

answer: @entity2


abstract: UNASSIGNED: @entity1 ( @entity1 ) is one of the natural mechanisms of @entity2 for limiting the spread of @entity0 and @entity4 parasitic mite. Objective of our study was to measure @entity1 of @entity2 unicolor colonies (N = 403) from three geographic regions (one infested and two free of @entity4 ) in Madagascar. The pin-killing method was used for evaluation of the @entity1 . Responses were measured from 3 h 30 min to 7 h after perforation of the cells. Colonies were very effective in detecting perforated cells. In the first 4 h, on average, they detected at least 50% of the pin-killed brood. Six hours after cell perforation, colonies tested (N = 91) showed a wide range of uncapped (0 to 100%) and cleaned cells (0 to 82%). Global distribution of the rate of cleaned cells at 6 h was multimodal and @entity3 responses could be split in three classes. Colonies from the three regions showed a significant difference in @entity1 responses. Three hypotheses (geographic, genetic traits, presence of @entity4 ) are further discussed to explain variability of @entity1 responses among the regions. Levels of @entity1 efficiency of A. mellifera unicolor colonies are among the greatest levels reported for A. mellifera subspecies. Presence of highly @entity3 colonies is a great opportunity for future breeding program in selection for @entity1 .

title: Assessing @entity3 behavior of @entity2 unicolor (Hymenoptera: Apidae), the endemic XXXX from Madagascar.

answer: @entity2


abstract: UNASSIGNED: @entity1 ( @entity1 ) is one of the natural mechanisms of @entity2 for limiting the spread of @entity0 and @entity4 parasitic mite. Objective of our study was to measure @entity1 of @entity2 unicolor colonies (N = 403) from three geographic regions (one infested and two free of @entity4 ) in Madagascar. The pin-killing method was used for evaluation of the @entity1 . Responses were measured from 3 h 30 min to 7 h after perforation of the cells. Colonies were very effective in detecting perforated cells. In the first 4 h, on average, they detected at least 50% of the pin-killed brood. Six hours after cell perforation, colonies tested (N = 91) showed a wide range of uncapped (0 to 100%) and cleaned cells (0 to 82%). Global distribution of the rate of cleaned cells at 6 h was multimodal and @entity3 responses could be split in three classes. Colonies from the three regions showed a significant difference in @entity1 responses. Three hypotheses (geographic, genetic traits, presence of @entity4 ) are further discussed to explain variability of @entity1 responses among the regions. Levels of @entity1 efficiency of A. mellifera unicolor colonies are among the greatest levels reported for A. mellifera subspecies. Presence of highly @entity3 colonies is a great opportunity for future breeding program in selection for @entity1 .

title: Assessing XXXX behavior of @entity2 unicolor (Hymenoptera: Apidae), the endemic @entity2 from Madagascar.

answer: @entity3


abstract: BACKGROUND: Aggressive anti- @entity1 treatments can result in @entity7 . Ovarian cryopreservation has been developed to preserve the fertility of young @entity0 , but early graft revascularisation still requires improvement. METHODS: Frozen/thawed @entity4 ovarian cortical biopsies were embedded in collagen matrix with or without isoform 165 of vascular endothelial growth factor ( @entity6 ) and transplanted into ovaries of @entity3 @entity2 . Ovaries were chosen as transplantation sites to more closely resemble clinical conditions in which orthotopic transplantation has previously allowed several spontaneous pregnancies. RESULTS: We found that @entity6 significantly increased the number of Dextran- @entity9 positive functional vessels 3  days after grafting. Dextran- @entity8 ( @entity9 ) positive vessels were detectable in 53% and 29% of the @entity2 in the @entity5 -treated and control groups, respectively. Among these positive fragments, 50% in the treated group displayed mature smooth-muscle-actin-alpha (alpha-SMA) positive functional vessels compared with 0% in the control group. @entity10 positive @entity2 blood vessels were observed in 40% of the @entity6 transplants compared with 21% of the controls. After 3  weeks, the density of @entity2 vessels was significantly higher in the @entity6 group. CONCLUSION: The encapsulation of ovarian tissue in collagen matrix in the presence of @entity6 before grafting has a positive effect on functional blood vessel recruitment. It can be considered as a useful technique to be improved and further developed before @entity0 clinical applications in female @entity1 @entity0 in the context of fertility preservation.

title: Isoform 165 of vascular endothelial growth factor in collagen matrix improves ovine cryopreserved ovarian tissue revascularisation after xenotransplantation in XXXX .

answer: @entity2


abstract: UNASSIGNED: We explored the immunomodulatory effects of bone marrow mesenchymal stem cells (BMSCs) on peripheral blood T lym-phocytes in @entity0 with decompensation stage, @entity4 -associated @entity1 . MSCs from nine @entity0 were analyzed by flow cytometry. Peripheral blood lymphocytes were isolated for fluorescent staining. Following stimulation by phytohemagglutinin (PHA), peripheral blood lymphocytes were co-cultured with BMSCs in serum and divided into four groups: (1) BMSC + lymphocyte + PHA contact culture group; (2) BMSC + lymphocyte + PHA non-contact culture group; (3) lym-phocyte + PHA positive control group; and (4) lymphocyte-only negative control group. Lymphocyte proliferation and frequencies of @entity2 (+)CD25(+)CD127(-) Tregs and @entity2 (+) @entity3 (-)IL-17(+) (Th17) cells were de-tected. Cell proliferation in groups 1 and 2 declined compared with group 3 (P < 0.01), and was notably higher than in group 4 (P < 0.01). @entity2 (+)CD25(+)CD127(-) Tregs frequencies in groups 1 and 2 were higher than in groups 3 and 4. In an intra-group comparison before and after culture, Th17 cell frequencies in groups 1 and 2 were higher than in group 4 (P < 0.01), but lower than in group 3 (P < 0.01). The Treg/Th17 ratio in groups 1 and 2 increased (P < 0.01), but did not change signifi-cantly in groups 3 and 4 (P > 0.05). In a comparison between groups after culture, the Treg/Th17 ratio in groups 1 and 2 increased more than in groups 3 and 4 (P < 0.01). BMSCs from cirrhotic @entity0 can inhibit the proliferation of peripheral blood T lymphocytes, upregulate the ex-pression of @entity2 (+)CD25(+)CD127(-) Tregs, and improve Treg/Th17 imbal-ance. The mechanism by which this takes place may be associated with immunomodulatory effects induced by the secretion of soluble factors.

title: Immunomodulatory effect of bone marrow mesenchymal stem cells on T lymphocytes in XXXX with decompensated liver cirrhosis.

answer: @entity0


abstract: The clinical presentation and results of management of septic @entity4 in 35 @entity0 over a seven-year period are reviewed. There were 25 @entity0 and ten @entity0 ; 20 @entity0 were over age 50. At diagnosis, @entity2 was present in 33 @entity0 (94%), and 33 (94%) had local signs of @entity1 . Pus was expressed from the infusion site in 25 @entity0 (71%). All @entity0 had plastic catheters, with 95% present longer than 48 hours. Klebsiella-Enterobacter was the dominant organism both at the infusion site and in the blood. All @entity0 had surgical excision of the infected vein, followed in 60% by rapid lysis of @entity2 . Other @entity3 were responsible for persistent @entity2 after total excision. @entity4 is best prevented by strict asepsis in catheter placement and rotation of infusion sites every 48 hours. Total excision of the infected vein remains the treatment of choice.

title: Catheter-associated septic XXXX .

answer: @entity4


abstract: BACKGROUND: Previous research has shown that electroacupuncture therapy has a potential therapeutic effect for simple female stress urinary @entity2 . In this study, pelvic floor muscle training, the first-line treatment for stress urinary @entity2 in @entity0 based on meta-analysis of numerous randomized control trials and recommended by international clinical practice, is used as a control group to demonstrate whether electroacupuncture therapy is a better method for female stress urinary @entity2 . METHODS/DESIGN: A randomized controlled trial has been designed to evaluate the therapeutic benefit of electroacupuncture for female stress urinary @entity2 compared with pelvic floor muscle training. The safety of electroacupuncture and @entity0 compliance will also be evaluated. Untoward reaction to the electroacupuncture, including a broken needle, fainting on acupuncture, or @entity1 during acupuncture, will be recorded and the therapy will be stopped if an untoward reaction occurs. After we have received full ethical approval and @entity0 consent, @entity0 will be randomized to receive a series of 24 electroacupuncture or pelvic floor muscle training interventions. The frequency and amount of leakage will be measured as the primary outcome parameters. Secondary outcome parameters include the 1-hour pad test, the short-form of the International Consultation on Incontinence Questionnaire, @entity0 subjective effectiveness evaluation, weekly usage of pad, and usage of specialty therapy for female stress urinary @entity2 . DISCUSSION: This trial will help to determine whether electroacupuncture is a more effective treatment than pelvic floor muscle training for @entity0 with female stress urinary @entity2 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01940432 (12 September 2013).

title: The efficacy of electroacupuncture for the treatment of simple female stress urinary XXXX - comparison with pelvic floor muscle training: study protocol for a multicenter randomized controlled trial.

answer: @entity2


abstract: PURPOSE: To evaluate the incidence of @entity3 ( @entity3 ) and recoverability of erectile function (EF) after anastomotic urethroplasty for traumatic urethral injuries (TUIs) of different etiologies. METHODS: A retrospective review for @entity0 ' records underwent perineal anastomotic urethroplasty for TUIs from June 1998 to January 2014 was conducted. Those @entity0 were contacted and evaluated using the International Index of erectile function questionnaire in sexually active @entity0 , and in unmarried @entity0 , the single-question self-report of @entity3 was used. @entity0 with @entity3 underwent penile color Doppler ultrasonography. RESULTS: Overall, 81 @entity0 were included in the study. The incidences of @entity3 following urethroplasty for TUIs were 72.3, 35.3 and 0  % in cases due to @entity2 , straddle and iatrogenic injuries, respectively. None of the @entity0 reported deterioration of EF after urethroplasty. Seven (13.5  %) @entity0 reported recovery of their EF within 2  years after @entity1 . The probability of recovery of EF after PFUI was 9  % compared to 28.6 and 100  % in @entity0 with straddle and iatrogenic urethral injuries, respectively. @entity0 with type C @entity2 had no chance for EF recoverability. CONCLUSIONS: PFUIs have a probability of causing @entity3 as much as 72  % compared to 35 and 0  % in @entity0 with straddle and iatrogenic urethral injuries, respectively. Anastomotic urethroplasty has no deleterious effect on EF. A tendency for higher recoverability of EF could be observed after iatrogenic urethral injuries followed by straddle injury then PFUIs. The probability of recovery decreased proportionally with severity of @entity4 .

title: XXXX post-perineal anastomotic urethroplasty for traumatic urethral injuries: analysis of incidence and possibility of recovery.

answer: @entity3


abstract: BACKGROUND: Myalgic @entity8 (ME/CFS) is a disease of unknown etiology. We previously reported a pilot case series followed by a small, randomized, placebo-controlled phase II study, suggesting that B-cell depletion using the monoclonal anti- @entity6 antibody rituximab can yield clinical benefit in ME/CFS. METHODS: In this single-center, open-label, one-armed phase II study (NCT01156909), 29 @entity0 were included for treatment with @entity7 (500 mg/m2) two infusions two weeks apart, followed by maintenance rituximab infusions after 3, 6, 10 and 15 months, and with follow-up for 36 months. FINDINGS: Major or moderate responses, predefined as lasting improvements in self-reported Fatigue score, were detected in 18 out of 29 @entity0 (intention to treat). Clinically significant responses were seen in 18 out of 28 @entity0 (64%) receiving rituximab maintenance treatment. For these 18 @entity0 , the mean response durations within the 156 weeks study period were 105 weeks in 14 major responders, and 69 weeks in four moderate responders. At end of follow-up (36 months), 11 out of 18 responding @entity0 were still in ongoing clinical remission. For major responders, the mean lag time from first rituximab infusion until start of clinical response was 23 weeks (range 8-66). Among the nine @entity0 from the placebo group in the previous randomized study with no significant improvement during 12 months follow-up after saline infusions, six achieved a clinical response before 12 months after rituximab maintenance infusions in the present study. Two @entity0 had an @entity1 to rituximab and two had an episode of uncomplicated late-onset @entity4 . Eight @entity0 experienced one or more transient symptom flares after rituximab infusions. There was no unexpected @entity2 . CONCLUSION: In a subgroup of ME/CFS @entity0 , prolonged B-cell depletion with rituximab maintenance infusions was associated with sustained clinical responses. The observed patterns of delayed responses and relapse after B-cell depletion and regeneration, a three times higher disease prevalence in @entity0 than in @entity0 , and a previously demonstrated increase in @entity5 risk for elderly ME/CFS @entity0 , suggest that ME/CFS may be a variant of an @entity3 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01156909.

title: B-Lymphocyte Depletion in Myalgic Encephalopathy/ XXXX . An Open-Label Phase II Study with Rituximab Maintenance Treatment.

answer: @entity8


abstract: BACKGROUND: The outcome of @entity0 after out-of-hospital @entity3 (OHCA) is poor and gets worse after prolonged resuscitation. Recently introduced attempts like an early installed emergency extracorporeal life support (E-ECLS) in @entity0 with persisting @entity3 at the @entity1 ( @entity1 ) are tried. The "Vienna Cardiac Arrest Registry" (VICAR) was introduced August 2013 to collect Utstein-style data. The aim of this observational study was to identify the incidence of @entity0 which @entity5 "load_go"-criteria for E-ECLS at the @entity1 . METHODS: VICAR was retrospectively analyzed for following criteria: age <75 years; witnessed OHCA; basic life support; @entity4 / @entity2 ; no return-of-spontaneous-circulation (ROSC) within 15min of advanced-life-support, which were supposed as potential optimal criteria for "load_go" plus successful E-ECLS treatment at the @entity1 . The observation period was from August 1, 2013 to July 31, 2014. RESULTS: Over 948 OHCA @entity0 registered during the study period; data were exploitable for 864 @entity0 . Of all @entity0 , "load_go"-criteria were fulfilled by 55 (6%). However, 96 (11%) were transported with on-going CPR to the @entity1 . Of these 96 @entity0 , only 16 (17%) met the "load_go"-criteria. Similarly, among the 96 @entity0 , 12 adults were treated with E-ECLS at the @entity1 , with only 5 meeting the criteria. Among these 12 @entity0 , favourable neurological outcome (CPC 1/2) was obtained in 1 @entity0 without criteria. CONCLUSION: Further promotion of these criteria within the ambulance crews is needed. May be these criteria could serve as a decision support for emergency physicians/paramedics, which @entity0 to transport with on-going CPR to the @entity1 for E-ECLS.

title: The incidence of "load_go" out-of-hospital @entity3 candidates for XXXX utilization of emergency extracorporeal life support: A one-year review.

answer: @entity1


abstract: BACKGROUND: The outcome of @entity0 after out-of-hospital @entity3 (OHCA) is poor and gets worse after prolonged resuscitation. Recently introduced attempts like an early installed emergency extracorporeal life support (E-ECLS) in @entity0 with persisting @entity3 at the @entity1 ( @entity1 ) are tried. The "Vienna Cardiac Arrest Registry" (VICAR) was introduced August 2013 to collect Utstein-style data. The aim of this observational study was to identify the incidence of @entity0 which @entity5 "load_go"-criteria for E-ECLS at the @entity1 . METHODS: VICAR was retrospectively analyzed for following criteria: age <75 years; witnessed OHCA; basic life support; @entity4 / @entity2 ; no return-of-spontaneous-circulation (ROSC) within 15min of advanced-life-support, which were supposed as potential optimal criteria for "load_go" plus successful E-ECLS treatment at the @entity1 . The observation period was from August 1, 2013 to July 31, 2014. RESULTS: Over 948 OHCA @entity0 registered during the study period; data were exploitable for 864 @entity0 . Of all @entity0 , "load_go"-criteria were fulfilled by 55 (6%). However, 96 (11%) were transported with on-going CPR to the @entity1 . Of these 96 @entity0 , only 16 (17%) met the "load_go"-criteria. Similarly, among the 96 @entity0 , 12 adults were treated with E-ECLS at the @entity1 , with only 5 meeting the criteria. Among these 12 @entity0 , favourable neurological outcome (CPC 1/2) was obtained in 1 @entity0 without criteria. CONCLUSION: Further promotion of these criteria within the ambulance crews is needed. May be these criteria could serve as a decision support for emergency physicians/paramedics, which @entity0 to transport with on-going CPR to the @entity1 for E-ECLS.

title: The incidence of "load_go" out-of-hospital XXXX candidates for @entity1 utilization of emergency extracorporeal life support: A one-year review.

answer: @entity3


abstract: BACKGROUND: Because circulating antibodies against a variety of antigens have been detected in @entity0 with @entity2 , @entity4 and those who have suffered a @entity1 , it is suspected that immune response may be one of the mechanisms of atherogenesis The objective of this study is to identify novel antibodies in @entity3 @entity0 by screening the expressed recombinant proteins using a @entity0 cDNA library (SEREX). METHODS: To identify the candidate antigens, cDNA library was screened by SEREX using plasma from ten @entity0 with @entity3 . Subsequently, via ELISA using recombinant proteins and synthetic peptides, the serum antibody levels were measured in two independent @entity0 /healthy donor (HD) cohorts (142 and 78 in the 2nd screening and a validation cohort, respectively). RESULTS: The initial screening resulted in the identification of six candidate antigens. Of these antigens, @entity5 ( @entity5 ) was determined to be the antigen associated with @entity1 (P   <   0.05) by ELISA with 2nd screening and validation cohort. Multifactorial logistic regression analysis showed that the increased levels of the @entity5 antibodies ( @entity5 -Abs) associated with @entity1 independent of other risk factors for @entity1 (P   <   0.05). Receiver operating curve analysis demonstrated that the area under the curve from ELISA using GST fusion @entity5 and synthetic peptides (bRPA2-132) were 0.867 (95% CI: 0.798-0.936) and 0.971 (95% CI: 0.940-1.00), respectively. If the cut-off value of the bRPA2-132-Ab level was determined to be 0.334, the sensitivity and specificity of the antibody level as the diagnostic marker for @entity1 were 0.323 (95% CI: 0.209-0.453) and 1.00 (95% CI: 0.713-1.00), respectively. CONCLUSIONS: SEREX identified @entity5 as the antigen associated with @entity3 and serum auto-antibodies against @entity5 elevates in @entity1 @entity0 . @entity5 -Abs could become a biomarker for the evaluation of @entity3 at risk.

title: Identification of XXXX -associated-antigens via screening of recombinant proteins from the @entity0 expression cDNA library (SEREX).

answer: @entity1


abstract: BACKGROUND: Because circulating antibodies against a variety of antigens have been detected in @entity0 with @entity2 , @entity4 and those who have suffered a @entity1 , it is suspected that immune response may be one of the mechanisms of atherogenesis The objective of this study is to identify novel antibodies in @entity3 @entity0 by screening the expressed recombinant proteins using a @entity0 cDNA library (SEREX). METHODS: To identify the candidate antigens, cDNA library was screened by SEREX using plasma from ten @entity0 with @entity3 . Subsequently, via ELISA using recombinant proteins and synthetic peptides, the serum antibody levels were measured in two independent @entity0 /healthy donor (HD) cohorts (142 and 78 in the 2nd screening and a validation cohort, respectively). RESULTS: The initial screening resulted in the identification of six candidate antigens. Of these antigens, @entity5 ( @entity5 ) was determined to be the antigen associated with @entity1 (P   <   0.05) by ELISA with 2nd screening and validation cohort. Multifactorial logistic regression analysis showed that the increased levels of the @entity5 antibodies ( @entity5 -Abs) associated with @entity1 independent of other risk factors for @entity1 (P   <   0.05). Receiver operating curve analysis demonstrated that the area under the curve from ELISA using GST fusion @entity5 and synthetic peptides (bRPA2-132) were 0.867 (95% CI: 0.798-0.936) and 0.971 (95% CI: 0.940-1.00), respectively. If the cut-off value of the bRPA2-132-Ab level was determined to be 0.334, the sensitivity and specificity of the antibody level as the diagnostic marker for @entity1 were 0.323 (95% CI: 0.209-0.453) and 1.00 (95% CI: 0.713-1.00), respectively. CONCLUSIONS: SEREX identified @entity5 as the antigen associated with @entity3 and serum auto-antibodies against @entity5 elevates in @entity1 @entity0 . @entity5 -Abs could become a biomarker for the evaluation of @entity3 at risk.

title: Identification of @entity1 -associated-antigens via screening of recombinant proteins from the XXXX expression cDNA library (SEREX).

answer: @entity0


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity2 , @entity8 and @entity1 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity0 ) against @entity4 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity12 and @entity9 ( @entity10 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity3 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity5 diet), trial-III (high @entity7 diet), trial-IV (high @entity5   +   high @entity7 diet). @entity3 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity3 were sacrificed and evaluated their serum lipid ( @entity5 , LDL and HDL), @entity6 and insulin levels. RESULTS: Results for feed consumption by @entity3 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity5 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity6 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity10 reduced the trait better than @entity12 based functional drink. CONCLUSIONS: The drinks supplemented with @entity12 and @entity10 are effective against @entity2 , @entity8 and @entity11 .

title: Preventive role of green tea @entity12 from @entity2 and @entity4 especially @entity8 and XXXX .

answer: @entity11


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity2 , @entity8 and @entity1 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity0 ) against @entity4 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity12 and @entity9 ( @entity10 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity3 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity5 diet), trial-III (high @entity7 diet), trial-IV (high @entity5   +   high @entity7 diet). @entity3 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity3 were sacrificed and evaluated their serum lipid ( @entity5 , LDL and HDL), @entity6 and insulin levels. RESULTS: Results for feed consumption by @entity3 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity5 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity6 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity10 reduced the trait better than @entity12 based functional drink. CONCLUSIONS: The drinks supplemented with @entity12 and @entity10 are effective against @entity2 , @entity8 and @entity11 .

title: Preventive role of green tea @entity12 from @entity2 and XXXX especially @entity8 and @entity11 .

answer: @entity4


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity2 , @entity8 and @entity1 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity0 ) against @entity4 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity12 and @entity9 ( @entity10 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity3 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity5 diet), trial-III (high @entity7 diet), trial-IV (high @entity5   +   high @entity7 diet). @entity3 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity3 were sacrificed and evaluated their serum lipid ( @entity5 , LDL and HDL), @entity6 and insulin levels. RESULTS: Results for feed consumption by @entity3 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity5 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity6 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity10 reduced the trait better than @entity12 based functional drink. CONCLUSIONS: The drinks supplemented with @entity12 and @entity10 are effective against @entity2 , @entity8 and @entity11 .

title: Preventive role of green tea @entity12 from XXXX and @entity4 especially @entity8 and @entity11 .

answer: @entity2


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity2 , @entity8 and @entity1 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity0 ) against @entity4 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity12 and @entity9 ( @entity10 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity3 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity5 diet), trial-III (high @entity7 diet), trial-IV (high @entity5   +   high @entity7 diet). @entity3 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity3 were sacrificed and evaluated their serum lipid ( @entity5 , LDL and HDL), @entity6 and insulin levels. RESULTS: Results for feed consumption by @entity3 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity5 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity6 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity10 reduced the trait better than @entity12 based functional drink. CONCLUSIONS: The drinks supplemented with @entity12 and @entity10 are effective against @entity2 , @entity8 and @entity11 .

title: Preventive role of green tea XXXX from @entity2 and @entity4 especially @entity8 and @entity11 .

answer: @entity12


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity2 , @entity8 and @entity1 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity0 ) against @entity4 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity12 and @entity9 ( @entity10 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity3 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity5 diet), trial-III (high @entity7 diet), trial-IV (high @entity5   +   high @entity7 diet). @entity3 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity3 were sacrificed and evaluated their serum lipid ( @entity5 , LDL and HDL), @entity6 and insulin levels. RESULTS: Results for feed consumption by @entity3 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity5 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity6 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity10 reduced the trait better than @entity12 based functional drink. CONCLUSIONS: The drinks supplemented with @entity12 and @entity10 are effective against @entity2 , @entity8 and @entity11 .

title: Preventive role of green tea @entity12 from @entity2 and @entity4 especially XXXX and @entity11 .

answer: @entity8


abstract: PURPOSE: We reviewed the @entity2 epidemiological data for the Mexico City metropolitan area (MCMA). METHODS: Data analysis from @entity0 (0-14  years old) diagnosed with @entity2 during the period 1996-2010 was performed at the Mexican @entity1 Registry. Histological subtype was determined according to the International Classification of @entity1 3 (ICCC-3). Age-adjusted incidence rates were calculated per 1,000,000 @entity0 /year by age, gender, and ICCC-3 subtype; trends, by @entity5 ( @entity5 ). RESULTS: A total of 328 @entity2 cases included in the study had an incidence rate of 11.8, showing a decreasing trend [ @entity5 : -3.5; CI95% (-5.9, -1.0)], primarily due to @entity4 ( @entity4 ) and @entity3 ( @entity3 ) mixed cellularity subtype. @entity4 had the major incidence (5.8), with the precursor cell subtype being the most frequent (38.3  %). @entity7 was the most frequent @entity3 subtype. The incidence of @entity6 was low (1.3). During the study period, there was an important reduction in the not-otherwise-specified @entity4 , which translated into a relative increase in the IIb3 subtype [ @entity5 : 7.3 (1.2, 13.8)]. Low incidences of @entity4 and of @entity3 and @entity4 were found for <1-year-olds and for 10- to 14-year-olds, respectively. Incidence rates for @entity0 in the MCMA, particularly the <1 and 10-14 age groups, were lower than those for developed countries. The overall male/female ratio was 2.3. CONCLUSIONS: There was a trend toward a reduced incidence, for some @entity2 subtypes, in particular for @entity2 , which may be the result of improvement in diagnostic techniques.

title: XXXX incidence patterns by ICCC-3 subtype in Mexico City metropolitan area population insured by Instituto Mexicano del Seguro Social, 1996-2010.

answer: @entity2