abstract: OBJECTIVE: The purpose of this prospective case series was to describe the outcome of a set of @entity0 with @entity3 treated with Graston Instrument Soft Tissue Mobilization techniques ( @entity2 ) and a home stretching program. METHODS: Ten @entity0 with a primary report of @entity1 completed self-report questionnaires including the Global Rating of Change Scale (GRC), the Numeric Pain Rating Scale, and the Lower Extremity Functional Scale. @entity0 were treated with @entity2 directed to the triceps surae, soleus, plantar fascia, and medial calcaneal tubercle. @entity0 received a maximum of 8 treatments over a time frame ranging from 3 to 8 weeks at a frequency of 1 to 2 sessions per week. Each @entity0 was instructed to perform the stretching program at home 3 times daily. @entity0 completed all outcome measures at baseline, sixth visit (GRC), and at discharge or the eighth visit. The number of successful outcomes on the GRC was examined using a binomial test. Dependent t tests were used to examine if a significant difference existed in secondary outcome measures of @entity1 and function. RESULTS: The subjects had a mean duration of symptoms of 32.4 weeks (SD, 31.1). @entity0 were treated for an average of 6.9 visits (SD, 1.3). There was a statistically significant difference between the number of @entity0 who did and did not achieve a successful outcome (P = .047). There was also a significant improvement from baseline to follow-up for the Numeric Pain Rating Scale (P = .002) and Lower Extremity Functional Scale (P = .017). CONCLUSIONS: The group of @entity0 selected for this case series who were treated with @entity2 and home stretching experienced clinically meaningful improvement.

title: Graston instrument soft tissue mobilization and home stretching for the management of XXXX : a case series.

answer: @entity1


abstract: OBJECTIVE: Reduction in energy usage has been investigated as the mechanism by which @entity5 provides protection during @entity1 . We describe experiments using @entity5 in the @entity2 retina in vitro that show a correlation between @entity5 -induced reductions in energy usage and neuroprotection. METHODS: We examined energy metabolism and electrophysiological function under control/nonischemic conditions during 1 or 2 hours of " @entity1 " (induced by decreasing @entity3 from 6 to 1 mmol/L and @entity0 from 95 to 15%) and during 3 to 4 hours of "return-to-control" conditions. @entity3 utilization and @entity4 production were measured as indices of energy metabolism, and light-evoked compound action potentials were monitored to assess functional recovery. RESULTS: Nonischemic retinas subjected to both mild (33 +/- 0.5 degrees C) and moderate (30 +/- 0.5 degrees C) @entity5 exhibited a decrease of 38% in the rate of @entity3 utilization and @entity4 production compared with normothermic retinas (36 +/- 0.5 degrees C) (analysis of variance, P < 0.001). In retinas that were made @entity1 , mild or moderate @entity5 further reduced the rates of @entity3 utilization (18 and 39%, respectively) and @entity4 production (21 and 28%, respectively) (P < 0.001 for @entity3 , P < 0.01 for @entity4 ). Retinas that had been mildly or moderately hypothermic during @entity1 exhibited improved recovery of @entity3 utilization (65 and 57%, respectively) and @entity4 production (72 and 74%, respectively) compared with normothermic retinas (18% for @entity3 and 54% for @entity4 ; repeated-measures analysis of variance, P < 0.001). Recovery of compound action potentials for retinas kept at 36, 33, and 30 degrees C was 15, 36, and 53%, respectively (repeated-measures analysis of variance, P < 0.001). CONCLUSION: Our studies in an avascular neuronal model of @entity1 demonstrate that @entity5 protects against @entity1 . We interpret the smaller reductions in energy generation and usage caused by @entity1 when the retinas were hypothermic as evidence that @entity5 had reduced energy requirements more than energy production, and we propose that this at least in part explains its protection.

title: Metabolic effects of XXXX and its neuroprotective effects on the recovery of metabolic and electrophysiological function in the @entity1 retina in vitro.

answer: @entity5


abstract: OBJECTIVE: Reduction in energy usage has been investigated as the mechanism by which @entity5 provides protection during @entity1 . We describe experiments using @entity5 in the @entity2 retina in vitro that show a correlation between @entity5 -induced reductions in energy usage and neuroprotection. METHODS: We examined energy metabolism and electrophysiological function under control/nonischemic conditions during 1 or 2 hours of " @entity1 " (induced by decreasing @entity3 from 6 to 1 mmol/L and @entity0 from 95 to 15%) and during 3 to 4 hours of "return-to-control" conditions. @entity3 utilization and @entity4 production were measured as indices of energy metabolism, and light-evoked compound action potentials were monitored to assess functional recovery. RESULTS: Nonischemic retinas subjected to both mild (33 +/- 0.5 degrees C) and moderate (30 +/- 0.5 degrees C) @entity5 exhibited a decrease of 38% in the rate of @entity3 utilization and @entity4 production compared with normothermic retinas (36 +/- 0.5 degrees C) (analysis of variance, P < 0.001). In retinas that were made @entity1 , mild or moderate @entity5 further reduced the rates of @entity3 utilization (18 and 39%, respectively) and @entity4 production (21 and 28%, respectively) (P < 0.001 for @entity3 , P < 0.01 for @entity4 ). Retinas that had been mildly or moderately hypothermic during @entity1 exhibited improved recovery of @entity3 utilization (65 and 57%, respectively) and @entity4 production (72 and 74%, respectively) compared with normothermic retinas (18% for @entity3 and 54% for @entity4 ; repeated-measures analysis of variance, P < 0.001). Recovery of compound action potentials for retinas kept at 36, 33, and 30 degrees C was 15, 36, and 53%, respectively (repeated-measures analysis of variance, P < 0.001). CONCLUSION: Our studies in an avascular neuronal model of @entity1 demonstrate that @entity5 protects against @entity1 . We interpret the smaller reductions in energy generation and usage caused by @entity1 when the retinas were hypothermic as evidence that @entity5 had reduced energy requirements more than energy production, and we propose that this at least in part explains its protection.

title: Metabolic effects of @entity5 and its neuroprotective effects on the recovery of metabolic and electrophysiological function in the XXXX retina in vitro.

answer: @entity1


abstract: UNASSIGNED: Marbled eels, @entity3 (Quoy _ Gaimard), cultured in Taiwan exhibited @entity2 and mortality in January 2012. The severely diseased eels bled from the gills and showed @entity1 filaments and @entity2 throughout the body similar to viral endothelial cell necrosis of eel. In this study, a novel polyomavirus (AmPyV) was isolated from the diseased eels using the AMPF cell line established from the pectoral fin of healthy marbled eels. AmPyV was found to encode a long T-antigen orthologous gene. Phylogenetic analysis showed that AmPyV was closely related to @entity4 endothelial cell-infecting virus. PCR assays revealed @entity0 throughout the systemic organs. AmPyV proliferated in the AMPF, EK-1 and EO-2 cells at temperatures 25-30    C, and the progeny virus yields were 10(7.0) , 10(7.4) and 10(7.7) TCID50   mL(-1) , respectively. The purified virions were icosahedral particles, 70-80  nm in diameter. No clinical signs or mortality was observed among the eels injected with the virus; however, the virus was reisolated from the brain, eyes, kidneys, fins and gills of infected eels 2  month after injection. Our results suggest that AmPyV exhibits a @entity0 . Pathogen of the disease needs to study further.

title: Isolation of a novel polyomavirus, related to XXXX endothelial cell-infecting virus, from marbled eels, @entity3 (Quoy _ Gaimard).

answer: @entity4


abstract: UNASSIGNED: Marbled eels, @entity3 (Quoy _ Gaimard), cultured in Taiwan exhibited @entity2 and mortality in January 2012. The severely diseased eels bled from the gills and showed @entity1 filaments and @entity2 throughout the body similar to viral endothelial cell necrosis of eel. In this study, a novel polyomavirus (AmPyV) was isolated from the diseased eels using the AMPF cell line established from the pectoral fin of healthy marbled eels. AmPyV was found to encode a long T-antigen orthologous gene. Phylogenetic analysis showed that AmPyV was closely related to @entity4 endothelial cell-infecting virus. PCR assays revealed @entity0 throughout the systemic organs. AmPyV proliferated in the AMPF, EK-1 and EO-2 cells at temperatures 25-30    C, and the progeny virus yields were 10(7.0) , 10(7.4) and 10(7.7) TCID50   mL(-1) , respectively. The purified virions were icosahedral particles, 70-80  nm in diameter. No clinical signs or mortality was observed among the eels injected with the virus; however, the virus was reisolated from the brain, eyes, kidneys, fins and gills of infected eels 2  month after injection. Our results suggest that AmPyV exhibits a @entity0 . Pathogen of the disease needs to study further.

title: Isolation of a novel polyomavirus, related to @entity4 endothelial cell-infecting virus, from marbled eels, XXXX (Quoy _ Gaimard).

answer: @entity3


abstract: UNASSIGNED: @entity5 including @entity1 are amongst the most debilitating @entity0 . There is an urgent need to develop methods to identify individuals at risk with greater precision and as early as possible. At present, a prerequisite for a diagnosis of @entity1 is the occurrence of a @entity4 . Therefore, attempting to detect @entity1 on the basis of @entity4 is analogous to diagnosing @entity2 ( @entity2 ) after the occurrence of a @entity3 ( @entity3 ). The introduction of cardiac stress testing (CST) has revolutionized the detection of @entity2 and the prevention and management of angina and @entity3 . In this paper, we attempt to apply lessons learnt from CST to the early detection of @entity4 by proposing the development of an analogous @entity4 stress test. We discuss in detail the various parameters of a proposed @entity4 stress test including the choice of a suitable psychological or psychopharmacological "stressor," target population, outcome measures, safety of the approach, and the necessary evolution of test to become clinically informative. The history of evolution of CST may guide the development of a similar approach for the detection and management of @entity5 . The initial development of a test to unmask latent risk for @entity1 will require the selection of a suitable and safe stimulus and the development of outcome measures as a prelude to testing in populations with a range of risk to determine predictive value. The use of CST in @entity2 offers the intriguing possibility that a similar approach may be applied to the detection and management of @entity1 .

title: The early identification of XXXX : can lessons be learnt from cardiac stress testing?

answer: @entity4


abstract: PURPOSE: In vitro studies have shown promising results for balloon-guided inflation tibioplasty. It was our hypothesis that this technique may be safe and effective for use in depressed lateral @entity2 . METHODS: We performed a prospective study of all @entity0 suffering from a depressed lateral @entity2 , managed in our institution with inflation tibioplasty and a resorbable @entity1 bone substitute injection, between January 2012 and December 2013. Twenty @entity0 , mean age 54.3        12. 8  years, suffering from a depressed lateral @entity2 ( @entity5 and III) were included. We then aimed to evaluate at a minimum follow-up of one year: (1) the rate of complications, (2) the clinical outcome ( @entity6 and @entity4 Outcome (KOO) and 12-Item Short Form Health Survey (SF-12) scores); and (3) the radiographic outcome (evaluated by CT-scan). RESULTS: No peri-operative complications occurred. In one @entity0 , @entity1 substitute was found in the infrapatellar fat pad on post-operative radiography with no clinical or radiographic consequences at one year. At one year after surgery, the KOO subscores were: Pain 80 (range 64-93), other symptoms 81.3 (69-93), daily living activities 81.9 (46-99), sport 65.83 (20-100), and quality of life 67.04 (31-100). The SF-12 activity component was 40.4 (28.6-52.2) and SF-12 mental component 47.71 (28 - 67.1). The mean depressed step-off of the lateral joint decreased from 10.7       4.8 mm pre-operatively to 2.7        1.7  mm post-operatively (p   <   0.0001). CONCLUSION: Our observations suggest that the use of balloon-guided inflation tibioplasty with injection of a resorbable bone substitute is safe, and results in a high rate of anatomic reduction and good clinical outcomes in @entity0 with @entity3 . LEVEL OF EVIDENCE: Therapeutic Level IV.

title: Balloon tibioplasty for reduction of XXXX : Preliminary radiographic and clinical results.

answer: @entity3


abstract: UNASSIGNED: More than 10% of all @entity0 treated with stereotactic body radiotherapy (SBRT) for primary @entity1 develop regional lymph node recurrence. We evaluated the dosimetric feasibility of SBRT with lobe-specific selective elective nodal irradiation (ENI) on dose-volume histograms. A total of 21 @entity0 were treated with SBRT for Stage I primary @entity1 between January 2010 and June 2012 at our institution. The extents of lobe-specific selective ENI fields were determined with reference to prior surgical reports. The ENI fields included lymph node stations (LNS) 3 + 4 + 11 for the @entity5 , LNS 7 + 11 for the right middle or lower @entity5 , LNS 5 + 11 for the @entity5 , and LNS 7 + 11 for the @entity5 . A composite plan was generated by combining the ENI plan and the SBRT plan and recalculating for biologically equivalent doses of 2 Gy per fraction, using a linear quadratic model. The V20 of the lung, D1cm(3) of the spinal cord, D1cm(3) and D10cm(3) of the esophagus and D10cm(3) of the tracheobronchial wall were evaluated. Of the 21 @entity0 , nine @entity0 (43%) could not fulfill the dose constraints. In all these @entity0 , the distance between the planning target volume ( @entity4 ) of ENI (PTVeni) and the @entity4 of SBRT (PTVsrt) was  <=2.0 cm. Of the three @entity0 who developed regional @entity2 , two @entity0 had isolated @entity3 , and the lymph node @entity2 was included within the ENI field. When the distance between the PTVeni and PTVsrt is >2.0 cm, SBRT with selective ENI may therefore dosimetrically feasible.

title: Dosimetric evaluation of the feasibility of stereotactic body radiotherapy for primary XXXX with lobe-specific selective elective nodal irradiation.

answer: @entity1


abstract: BACKGROUND: @entity0 with primary @entity1 (PR- @entity3 ) have a dismal prognosis when treated with conventional salvage chemotherapy. We analyzed time to treatment failure (TTF), @entity2 ( @entity2 ) and clinical variables influencing the outcome in @entity0 undergoing autologous stem cell transplantation (ASCT) for PR- @entity3 and reported to the Grupo Espa  ol de Linfomas/Trasplante Aut  logo de M  dula Osea (GEL/ @entity4 ). @entity0 AND METHODS: Sixty-two @entity0 , 41 males and 21 females with a median age of 27 years (range 13-55) were analyzed. Forty-two @entity0 (68%) had advanced stage at diagnosis, 47 (76%) presented with B symptoms and 29 (47%) with a bulky mediastinal mass. Seventy-five percent of the @entity0 had received more than one line of therapy before ASCT. Thirty-three @entity0 received bone marrow as a source of hematopoietic progenitors, and 29 peripheral blood. Six @entity0 were conditioned with high-dose chemotherapy plus total-body irradiation and 56 received chemotherapy-based protocols. RESULTS: One-year transplantation-related mortality was 14% [95% confidence interval (CI) 6% to 23%]. Response rate at 3 months after ASCT was 52% [complete remission in 21 @entity0 (34%), partial remission in 11 @entity0 (18%)]. Actuarial 5-year TTF and @entity2 were 15% (95% CI 5% to 24%) and 26% (95% CI 13% to 39%), respectively. The presence of B symptoms at ASCT was the only adverse prognostic factor significantly influencing TTF [relative risk (RR) 1.75, 95% CI 0.92-3.35, P = 0.08]. The presence of B symptoms at diagnosis (RR 2.08, 95% CI 0.90-4.79, P = 0.08), MOPP-like regimens as first-line therapy (RR 3.84, 95% CI 1.69-9.09, P = 0.001), bulky disease at ASCT (RR 2.79, 95% CI 0.29-6.03, P = 0.009) and two or more lines of therapy before ASCT (RR 2.24, 95% CI 0.95-5.27, P = 0.06) adversely influenced @entity2 . CONCLUSIONS: In our experience, although overall results of ASCT in PR- @entity3 @entity0 are poor, one-quarter of the @entity0 remain alive at 5 years. Despite this, other therapeutic strategies should be investigated in this group of @entity0 to improve the outcome.

title: Autologous stem cell transplantation for primary XXXX : results and clinical variables affecting outcome.

answer: @entity1


abstract: PURPOSE: To compare the subjective and objective cure rates, @entity3 , @entity2 , and postoperative quality of life of adjustable single-incision sling (Ajust(  )) versus tension-free vaginal tape-obturator (TVT-O   ) in the treatment of female @entity4 ( @entity4 ). METHODS: Female @entity0 with @entity4 (N  =  368) were randomized to receive either Ajust(  ) (N  =  184) or TVT-O    procedure (N  =  184) between January 2012 and October 2013. Efficacy was evaluated using cure rate, @entity2 , @entity3 profile (using Visual Analogue Scale), @entity0 Global Impression of Improvement Scale, and International Consultation on Incontinence Questionnaire-Short Form. RESULTS: The @entity0 from Ajust(  ) and TVT-O    groups had no statistically significant difference in subjective and objective cure rates (94.4 vs 90.7  %, P  =  0.171; 97.2 vs 90.7  %, P  =  0.195). Compared with the TVT-O    group, @entity0 in the Ajust(  ) group had significantly less @entity3 , shorter operative duration, and less intraoperative @entity1 (all P values  <  0.05). No significant difference in perioperative complications was observed between these two groups. @entity0 in Ajust(  ) group had shorter recovery time (P  <  0.001) compared to TVT-O    group. The postoperative quality of life of @entity0 in these two groups was significantly improved compared to baseline; however, no significant difference was observed in the average improvement of life between these two groups (P  =  0.115). CONCLUSIONS: Ajust(  ) procedure is simple, safe, and effective for the treatment of @entity4 . Compared with TVT-O   , @entity0 receiving Ajust(  ) had less intraoperative @entity1 , less @entity3 , and shorter recovery time.

title: A comparison between adjustable single-incision sling and tension-free vaginal tape-obturator in treating XXXX .

answer: @entity4


abstract: UNASSIGNED: Preclinical studies indicate that stress early in life can cause long-term alterations in brain development. Studies have shown alterations in the brain functions of @entity0 after experiencing @entity1 . Our aim is to examine whether the integrity of white matter tracts might be affected in @entity2 ( @entity2 ) @entity0 . A total of 15 @entity2 @entity0 and 15 healthy controls were studied, with the groups matched by age and gender. Diffusion-weighted echoplanar brain images were obtained using a 1.5 Tesla magnetic resonance imaging scanner. Regions of interest were manually placed on directional maps based on principal anisotropy. Apparent diffusion coefficient and fractional anisotropy (FA) values of white matter were measured bilaterally in the anterior corona radiata (ACR) and by diffusion tensor imaging in the genu and splenium of the corpus callosum. Significantly lower FA values were observed in the right ACR of @entity2 @entity0 versus healthy individuals. We also found an association between bad paternal relationships and lower FA in the genu of the corpus callosum in female @entity0 . Alterations in the right ACR suggest that diffusion anisotropy measurement can be used as a quantitative biomarker for @entity2 . Paternal relationships may also affect the brain's microstructure in @entity0 with @entity2 .

title: Tracking down the footprints of bad paternal relationships in XXXX : A diffusion tensor imaging study.

answer: @entity2


abstract: The hypothesis is presented that @entity3 after @entity5 is principally due to @entity4 of sufficient severity and duration. In a group of 103 @entity0 who underwent surgery during a 10-year period, the distal aortic pressure was maintained above 60 mm Hg while the aorta was cross-clamped or the period of cross-clamping was limited to less than 20 minutes. No @entity1 occurred. In 17 of the 103 cases aortic pressure decreased below 60 mm Hg, occurring in 8% of @entity0 with the aorta occluded below the left subclavian artery but in 30% of those occluded above. Therapeutic measures used in the 17 @entity0 included infusion of @entity6 in five and limiting cross-clamp time to less than 20 minutes in 11. The theory is proposed that ligation of intercostal arteries in a @entity0 with @entity5 cannot injure the spinal cord because the normal direction of blood flow is reversed. Certainly, in @entity0 without a @entity5 , such as @entity2 , ligation of a critical intercostal artery may injure the spinal cord. However, in @entity0 with @entity5 the direction of blood flow is reversed, blood flowing from the intercostals into the distal aorta. The vague relationship long noted between development of collateral circulation, including rib notching, and the frequency of @entity3 probably depends not on the presence of enlarged intercostal arteries but on whether their temporary occlusion at the time of aortic cross-clamping results in @entity4 . Data with somatosensory-evoked potentials measured during operations on the thoracic aorta in 25 @entity0 found no changes in sensory potentials as long as the distal aortic pressure remained above 60 mm Hg, but a gradual disappearance was found at lower pressures. In five of six @entity0 with large thoracicoabdominal @entity2 in whom sensory potentials were absent for longer than 30 minutes, @entity3 resulted. Use of somatosensory potentials provides a significant method for evaluating methods to protect from @entity3 . This method should be far more productive than are simple clinical experiences because the fortunate rare occurrence of @entity3 , one in 200, greatly limits available data.

title: Is @entity3 after repair of XXXX due principally to @entity4 during aortic cross-clamping?

answer: @entity5


abstract: The hypothesis is presented that @entity3 after @entity5 is principally due to @entity4 of sufficient severity and duration. In a group of 103 @entity0 who underwent surgery during a 10-year period, the distal aortic pressure was maintained above 60 mm Hg while the aorta was cross-clamped or the period of cross-clamping was limited to less than 20 minutes. No @entity1 occurred. In 17 of the 103 cases aortic pressure decreased below 60 mm Hg, occurring in 8% of @entity0 with the aorta occluded below the left subclavian artery but in 30% of those occluded above. Therapeutic measures used in the 17 @entity0 included infusion of @entity6 in five and limiting cross-clamp time to less than 20 minutes in 11. The theory is proposed that ligation of intercostal arteries in a @entity0 with @entity5 cannot injure the spinal cord because the normal direction of blood flow is reversed. Certainly, in @entity0 without a @entity5 , such as @entity2 , ligation of a critical intercostal artery may injure the spinal cord. However, in @entity0 with @entity5 the direction of blood flow is reversed, blood flowing from the intercostals into the distal aorta. The vague relationship long noted between development of collateral circulation, including rib notching, and the frequency of @entity3 probably depends not on the presence of enlarged intercostal arteries but on whether their temporary occlusion at the time of aortic cross-clamping results in @entity4 . Data with somatosensory-evoked potentials measured during operations on the thoracic aorta in 25 @entity0 found no changes in sensory potentials as long as the distal aortic pressure remained above 60 mm Hg, but a gradual disappearance was found at lower pressures. In five of six @entity0 with large thoracicoabdominal @entity2 in whom sensory potentials were absent for longer than 30 minutes, @entity3 resulted. Use of somatosensory potentials provides a significant method for evaluating methods to protect from @entity3 . This method should be far more productive than are simple clinical experiences because the fortunate rare occurrence of @entity3 , one in 200, greatly limits available data.

title: Is @entity3 after repair of @entity5 due principally to XXXX during aortic cross-clamping?

answer: @entity4


abstract: The hypothesis is presented that @entity3 after @entity5 is principally due to @entity4 of sufficient severity and duration. In a group of 103 @entity0 who underwent surgery during a 10-year period, the distal aortic pressure was maintained above 60 mm Hg while the aorta was cross-clamped or the period of cross-clamping was limited to less than 20 minutes. No @entity1 occurred. In 17 of the 103 cases aortic pressure decreased below 60 mm Hg, occurring in 8% of @entity0 with the aorta occluded below the left subclavian artery but in 30% of those occluded above. Therapeutic measures used in the 17 @entity0 included infusion of @entity6 in five and limiting cross-clamp time to less than 20 minutes in 11. The theory is proposed that ligation of intercostal arteries in a @entity0 with @entity5 cannot injure the spinal cord because the normal direction of blood flow is reversed. Certainly, in @entity0 without a @entity5 , such as @entity2 , ligation of a critical intercostal artery may injure the spinal cord. However, in @entity0 with @entity5 the direction of blood flow is reversed, blood flowing from the intercostals into the distal aorta. The vague relationship long noted between development of collateral circulation, including rib notching, and the frequency of @entity3 probably depends not on the presence of enlarged intercostal arteries but on whether their temporary occlusion at the time of aortic cross-clamping results in @entity4 . Data with somatosensory-evoked potentials measured during operations on the thoracic aorta in 25 @entity0 found no changes in sensory potentials as long as the distal aortic pressure remained above 60 mm Hg, but a gradual disappearance was found at lower pressures. In five of six @entity0 with large thoracicoabdominal @entity2 in whom sensory potentials were absent for longer than 30 minutes, @entity3 resulted. Use of somatosensory potentials provides a significant method for evaluating methods to protect from @entity3 . This method should be far more productive than are simple clinical experiences because the fortunate rare occurrence of @entity3 , one in 200, greatly limits available data.

title: Is XXXX after repair of @entity5 due principally to @entity4 during aortic cross-clamping?

answer: @entity3


abstract: This study was undertaken to examine some of the quantitative and qualitative changes which might occur in the cerebral granular pericyte population when comparing control and embolically stressed animals. Eight animals, male NZW 2-2.5 kg @entity1 , were given intracarotid sublethal injections of @entity0 @entity4 concentrated at 125 mg/ml. Eight others received 1 cc of sterile saline. Two hours after injection the brains were fixed with either neutral buffered @entity2 or 3% buffered @entity5 by cardiac perfusion at 110 mmHg pressure. The brains were removed and sliced, anteroposteriorly, in 3 mm slices. Each slice from five brains for each condition was then processed for paraffin sectioning and staining with @entity3 and PAS. Two animals for each condition underwent the same treatments and were processed for frozen sectioning and staining with @entity6 . One animal for each condition had each brain slice sectioned by vibratome (40 micrometers) and was processed appropriately and examined by either fluorescence microscopy, standard electron microscopy or acid phosphatase electron microscopy. In the groups stained with @entity3 and PAS, granular pericytes were counted for each of the first five levels of each brain for both the control and experimental conditions. The results of this study reconfirmed that these cells were granular pericytes; that is, they were autofluorescent and PAS positive; were surrounded by a basement membrane, were acid phosphatase positive and contained a heterogenous granular cytoplasmic inclusion population. Further, after ischemic insult, the number of granular pericytes increased significantly at two hours. It was also shown that these cells appeared capable of accumulating lipid components of the injected @entity4 from the vessel lumen.

title: Reactions of granular pericytes in a XXXX cerebrovascular ischemia model.

answer: @entity1


abstract: PURPOSE: @entity3 pathway inhibitors have been investigated as therapeutic agents in the treatment of @entity6 ( @entity6 ) because of its central role in angiogenesis. These agents have improved survival in @entity0 with advanced @entity6 , but the effects have been modest. Although @entity4 /KDRis typically localized to the vasculature, amplification ofKDRhas reported to occur in 9% to 30% of the DNA from different @entity1 . We investigated the signaling pathways activated downstream ofKDRand whetherKDRamplification is associated with benefit in @entity0 with @entity6 treated with the @entity4 inhibitor @entity11 . METHODS: @entity6 cell lines with or withoutKDRamplification were studied for the effects of @entity4 @entity10 kinase inhibitors (TKI) on cell viability and migration. @entity2 samples collected from @entity0 with @entity5 -refractory @entity6 in the phase III ZODIAC study of @entity11 plus @entity7 or placebo plus @entity7 (N= 294) were screened forKDRamplification by FISH. RESULTS: KDRamplification was associated with @entity3 -induced activation of @entity9 , @entity8 , and invasiveness in @entity6 cell lines. However, @entity4 TKIs did not inhibit proliferation of @entity6 cell lines withKDRamplification. @entity4 inhibition decreased cell motility as well as expression of @entity12 inKDR-amplified @entity6 cells. In the ZODIAC study,KDRamplification was observed in 15% of @entity0 and was not associated with improved progression-free survival, overall survival, or objective response rate for the @entity11 arm. CONCLUSIONS: Preclinical studies suggestKDRactivates invasion but not survival pathways inKDR-amplified @entity6 models. @entity0 with @entity6 whose @entity2 hadKDRamplification were not associated with clinical benefit for @entity11 in combination with @entity7 .Clin Cancer Res; 22(8); 1940-50.   2015 AACR.

title: @entity4 Amplification Is Associated with XXXX -Induced Activation of the @entity9 and Invasion Pathways but does not Predict Clinical Benefit to the @entity4 TKI @entity11 .

answer: @entity3


abstract: PURPOSE: @entity3 pathway inhibitors have been investigated as therapeutic agents in the treatment of @entity6 ( @entity6 ) because of its central role in angiogenesis. These agents have improved survival in @entity0 with advanced @entity6 , but the effects have been modest. Although @entity4 /KDRis typically localized to the vasculature, amplification ofKDRhas reported to occur in 9% to 30% of the DNA from different @entity1 . We investigated the signaling pathways activated downstream ofKDRand whetherKDRamplification is associated with benefit in @entity0 with @entity6 treated with the @entity4 inhibitor @entity11 . METHODS: @entity6 cell lines with or withoutKDRamplification were studied for the effects of @entity4 @entity10 kinase inhibitors (TKI) on cell viability and migration. @entity2 samples collected from @entity0 with @entity5 -refractory @entity6 in the phase III ZODIAC study of @entity11 plus @entity7 or placebo plus @entity7 (N= 294) were screened forKDRamplification by FISH. RESULTS: KDRamplification was associated with @entity3 -induced activation of @entity9 , @entity8 , and invasiveness in @entity6 cell lines. However, @entity4 TKIs did not inhibit proliferation of @entity6 cell lines withKDRamplification. @entity4 inhibition decreased cell motility as well as expression of @entity12 inKDR-amplified @entity6 cells. In the ZODIAC study,KDRamplification was observed in 15% of @entity0 and was not associated with improved progression-free survival, overall survival, or objective response rate for the @entity11 arm. CONCLUSIONS: Preclinical studies suggestKDRactivates invasion but not survival pathways inKDR-amplified @entity6 models. @entity0 with @entity6 whose @entity2 hadKDRamplification were not associated with clinical benefit for @entity11 in combination with @entity7 .Clin Cancer Res; 22(8); 1940-50.   2015 AACR.

title: @entity4 Amplification Is Associated with @entity3 -Induced Activation of the XXXX and Invasion Pathways but does not Predict Clinical Benefit to the @entity4 TKI @entity11 .

answer: @entity9


abstract: PURPOSE: @entity3 pathway inhibitors have been investigated as therapeutic agents in the treatment of @entity6 ( @entity6 ) because of its central role in angiogenesis. These agents have improved survival in @entity0 with advanced @entity6 , but the effects have been modest. Although @entity4 /KDRis typically localized to the vasculature, amplification ofKDRhas reported to occur in 9% to 30% of the DNA from different @entity1 . We investigated the signaling pathways activated downstream ofKDRand whetherKDRamplification is associated with benefit in @entity0 with @entity6 treated with the @entity4 inhibitor @entity11 . METHODS: @entity6 cell lines with or withoutKDRamplification were studied for the effects of @entity4 @entity10 kinase inhibitors (TKI) on cell viability and migration. @entity2 samples collected from @entity0 with @entity5 -refractory @entity6 in the phase III ZODIAC study of @entity11 plus @entity7 or placebo plus @entity7 (N= 294) were screened forKDRamplification by FISH. RESULTS: KDRamplification was associated with @entity3 -induced activation of @entity9 , @entity8 , and invasiveness in @entity6 cell lines. However, @entity4 TKIs did not inhibit proliferation of @entity6 cell lines withKDRamplification. @entity4 inhibition decreased cell motility as well as expression of @entity12 inKDR-amplified @entity6 cells. In the ZODIAC study,KDRamplification was observed in 15% of @entity0 and was not associated with improved progression-free survival, overall survival, or objective response rate for the @entity11 arm. CONCLUSIONS: Preclinical studies suggestKDRactivates invasion but not survival pathways inKDR-amplified @entity6 models. @entity0 with @entity6 whose @entity2 hadKDRamplification were not associated with clinical benefit for @entity11 in combination with @entity7 .Clin Cancer Res; 22(8); 1940-50.   2015 AACR.

title: XXXX Amplification Is Associated with @entity3 -Induced Activation of the @entity9 and Invasion Pathways but does not Predict Clinical Benefit to the @entity4 TKI @entity11 .

answer: @entity4


abstract: PURPOSE: @entity3 pathway inhibitors have been investigated as therapeutic agents in the treatment of @entity6 ( @entity6 ) because of its central role in angiogenesis. These agents have improved survival in @entity0 with advanced @entity6 , but the effects have been modest. Although @entity4 /KDRis typically localized to the vasculature, amplification ofKDRhas reported to occur in 9% to 30% of the DNA from different @entity1 . We investigated the signaling pathways activated downstream ofKDRand whetherKDRamplification is associated with benefit in @entity0 with @entity6 treated with the @entity4 inhibitor @entity11 . METHODS: @entity6 cell lines with or withoutKDRamplification were studied for the effects of @entity4 @entity10 kinase inhibitors (TKI) on cell viability and migration. @entity2 samples collected from @entity0 with @entity5 -refractory @entity6 in the phase III ZODIAC study of @entity11 plus @entity7 or placebo plus @entity7 (N= 294) were screened forKDRamplification by FISH. RESULTS: KDRamplification was associated with @entity3 -induced activation of @entity9 , @entity8 , and invasiveness in @entity6 cell lines. However, @entity4 TKIs did not inhibit proliferation of @entity6 cell lines withKDRamplification. @entity4 inhibition decreased cell motility as well as expression of @entity12 inKDR-amplified @entity6 cells. In the ZODIAC study,KDRamplification was observed in 15% of @entity0 and was not associated with improved progression-free survival, overall survival, or objective response rate for the @entity11 arm. CONCLUSIONS: Preclinical studies suggestKDRactivates invasion but not survival pathways inKDR-amplified @entity6 models. @entity0 with @entity6 whose @entity2 hadKDRamplification were not associated with clinical benefit for @entity11 in combination with @entity7 .Clin Cancer Res; 22(8); 1940-50.   2015 AACR.

title: @entity4 Amplification Is Associated with @entity3 -Induced Activation of the @entity9 and Invasion Pathways but does not Predict Clinical Benefit to the XXXX TKI @entity11 .

answer: @entity4


abstract: PURPOSE: @entity3 pathway inhibitors have been investigated as therapeutic agents in the treatment of @entity6 ( @entity6 ) because of its central role in angiogenesis. These agents have improved survival in @entity0 with advanced @entity6 , but the effects have been modest. Although @entity4 /KDRis typically localized to the vasculature, amplification ofKDRhas reported to occur in 9% to 30% of the DNA from different @entity1 . We investigated the signaling pathways activated downstream ofKDRand whetherKDRamplification is associated with benefit in @entity0 with @entity6 treated with the @entity4 inhibitor @entity11 . METHODS: @entity6 cell lines with or withoutKDRamplification were studied for the effects of @entity4 @entity10 kinase inhibitors (TKI) on cell viability and migration. @entity2 samples collected from @entity0 with @entity5 -refractory @entity6 in the phase III ZODIAC study of @entity11 plus @entity7 or placebo plus @entity7 (N= 294) were screened forKDRamplification by FISH. RESULTS: KDRamplification was associated with @entity3 -induced activation of @entity9 , @entity8 , and invasiveness in @entity6 cell lines. However, @entity4 TKIs did not inhibit proliferation of @entity6 cell lines withKDRamplification. @entity4 inhibition decreased cell motility as well as expression of @entity12 inKDR-amplified @entity6 cells. In the ZODIAC study,KDRamplification was observed in 15% of @entity0 and was not associated with improved progression-free survival, overall survival, or objective response rate for the @entity11 arm. CONCLUSIONS: Preclinical studies suggestKDRactivates invasion but not survival pathways inKDR-amplified @entity6 models. @entity0 with @entity6 whose @entity2 hadKDRamplification were not associated with clinical benefit for @entity11 in combination with @entity7 .Clin Cancer Res; 22(8); 1940-50.   2015 AACR.

title: @entity4 Amplification Is Associated with @entity3 -Induced Activation of the @entity9 and Invasion Pathways but does not Predict Clinical Benefit to the @entity4 TKI XXXX .

answer: @entity11


abstract: BACKGROUND: Facelift (rhytidectomy) is a prominent technique for facial rejuvenation with 126 713 performed in the United States in 2014. Current literature on facelift complications is inconclusive and derives from retrospective studies. OBJECTIVES: This study reports the incidence and risk factors of major complications following facelift in a large, prospective, multi-center database. It compares complications of facelifts done alone or in combination with other cosmetic surgical procedures. METHODS: A prospective cohort of @entity0 undergoing facelift between 2008 and 2013 was identified from the CosmetAssure database. Primary outcome was occurrence of major complications, defined as complications requiring emergency room (ER) visit, hospital admission, or reoperation within 30 days of the procedure. Univariate and multivariate analysis evaluated risk factors including age, gender, BMI, smoking, @entity1 , combined procedures, and type of surgical facility. RESULTS: Of the 129 007 @entity0 enrolled in CosmetAssure, 11 300 (8.8%) underwent facelifts. Facelift cohort had more males (8.8%), @entity1 (2.7%), elderly (mean age 59.2 years) and @entity2 (38.5%) induviduals, but fewer smokers (4.8%). Combined procedures accounted for 57.4% of facelifts. Facelifts had a 1.8% complication rate, similar to the rate of 2% associated to other cosmetic surgeries. @entity4 (1.1%) and @entity3 (0.3%) were most common. Combined procedures had up to 3.7% complication rate compared to 1.5% in facelifts alone. Male gender (relative risk 3.9) and type of facility (relative risk 2.6) were independent predictors of @entity4 . Combined procedures (relative risk 3.5) and BMI >=  25 (relative risk 2.8) increased @entity3 risk. CONCLUSIONS: Rhytidectomy is a very safe procedure in the hands of board-certified plastic surgeons. @entity4 and @entity3 are the most common major complications. Male gender, BMI >=  25, and combined procedures are independent risk factors. LEVEL OF EVIDENCE 2: Risk.

title: Preoperative Risk Factors and Complication Rates in Facelift: Analysis of 11,300 XXXX .

answer: @entity0


abstract: BACKGROUND: Fractures of the radial neck in @entity0 are usually seen at about the age of five years, after the appearance of the proximal radial epiphysis. They are usually caused by a fall on the outstretched hand which produces a valgus strain [1]. Minor degrees of angulation can be accepted and treated conservatively, but advice on the maximum acceptable angulation varies widely, up to as much as 45  0 [2] More severely angulated and displaced @entity1 have been variously treated by closed or open reduction, but the precise indications for each are not clear [3]. In a retrospective study Steele et al. found that open reduction generally had a poor result and that open reduction with internal fixation was even worse, as has been reported by others [4, 5]. METHODS: We describe a modified percutaneous technique using two (1.6  mm) K-wires for reduction (one wire for leverage and one wire for translation) and two K-wires for rotationally stable fixation. RESULTS: Nine @entity0 were included in the study. The median age of the @entity0 was 9.6  years. There were six males and three females. The average follow up period was 23  months. The final results of the study included six @entity0 with excellent results and one with a good result. Unfortunately, two @entity0 were visitors and failed to attend for review. CONCLUSION: We have found this technique effective and easily reproducible. Level of evidence IV - Case series.

title: Percutaneous Reduction and Fixation Using Two K-wires In XXXX .

answer: @entity1


abstract: Avian influenza virus can be divided into two groups, highly pathogenic avian influenza virus (HPAI) and low pathogenic avian influenza virus (LPAI) based on their difference in virulence. To investigate if the difference in clinical outcome between LPAI and HPAI in @entity2 is due to immunological host responses in the lung within the first 24 hours post @entity0 (hpi), @entity2 were infected with LPAI or @entity1 . Virus was found in the caudal and cranial part of the lung. With LPAI, virus was localised around the intrapulmonary bronchus and secondary bronchi. In sharp contrast, HPAI was detected throughout the whole lung. However, based on viral RNA levels, no quantitative difference was observed between LPAI and @entity1 birds. In infected areas of the lungs, an influx of @entity3 + cells as well as KUL01+ macrophages and dendritic cells (DC) occurred as fast as 8 hpi in both infected groups. No major difference between LPAI and @entity1 birds in the induction of cytokines and interferons at mRNA level in lung tissue was found.In conclusion, the differences in lethality for @entity2 infected with LPAI or HPAI could be ascribed to difference in location of the virus. However similar amounts of viral RNA, similar cytokine mRNA levels, and similar influxes of @entity3 + and KUL01+ macrophages and DC were found between HPAI and LPAI in the lungs. A cytokine storm at mRNA level as described for mammals was not observed in the lungs of @entity1 birds within 24 hpi.

title: Highly pathogenic or low pathogenic avian influenza virus subtype @entity0 in XXXX lungs: small differences in general acute responses.

answer: @entity2


abstract: Avian influenza virus can be divided into two groups, highly pathogenic avian influenza virus (HPAI) and low pathogenic avian influenza virus (LPAI) based on their difference in virulence. To investigate if the difference in clinical outcome between LPAI and HPAI in @entity2 is due to immunological host responses in the lung within the first 24 hours post @entity0 (hpi), @entity2 were infected with LPAI or @entity1 . Virus was found in the caudal and cranial part of the lung. With LPAI, virus was localised around the intrapulmonary bronchus and secondary bronchi. In sharp contrast, HPAI was detected throughout the whole lung. However, based on viral RNA levels, no quantitative difference was observed between LPAI and @entity1 birds. In infected areas of the lungs, an influx of @entity3 + cells as well as KUL01+ macrophages and dendritic cells (DC) occurred as fast as 8 hpi in both infected groups. No major difference between LPAI and @entity1 birds in the induction of cytokines and interferons at mRNA level in lung tissue was found.In conclusion, the differences in lethality for @entity2 infected with LPAI or HPAI could be ascribed to difference in location of the virus. However similar amounts of viral RNA, similar cytokine mRNA levels, and similar influxes of @entity3 + and KUL01+ macrophages and DC were found between HPAI and LPAI in the lungs. A cytokine storm at mRNA level as described for mammals was not observed in the lungs of @entity1 birds within 24 hpi.

title: Highly pathogenic or low pathogenic avian influenza virus subtype XXXX in @entity2 lungs: small differences in general acute responses.

answer: @entity0


abstract: Although it is generally held that about 10% of the population is left-handed, reported figures vary widely due to differences in handedness classification criteria and subject characteristics. Among those population studies that have used the same handedness classification criteria, a consistent relationship between increasing right-hand preference and increasing age has been reported. One recent study of @entity2 ( @entity2 ) reported a higher incidence of @entity5 in early onset relative to late onset cases. In the present study we examined handedness patterns in three elderly groups; normal (N = 217), @entity4 (N = 73), and @entity2 (N = 114). Our results indicated a reduced frequency of @entity5 in @entity2 (2.6%) relative to control (11.1%) and @entity4 (13.7%) groups. Within the limited age range we studied (60-80 years), no relationships were found between age and handedness preference either within or across the groups. Furthermore, for the @entity2 group there was no relationship between severity of @entity1 and strength of handedness. Our results suggest that compared to right handers, left handers are less vulnerable to the cognitive changes associated with @entity2 . Nevertheless it is also possible that left handers are overrepresented among early onset @entity3 @entity0 and die before entering the pool of @entity2 @entity0 . Further work is required to determine if early and late onset @entity2 are associated with different incidences of @entity5 .

title: Reduced incidence of XXXX in clinically diagnosed @entity3 of the Alzheimer type.

answer: @entity5


abstract: Although it is generally held that about 10% of the population is left-handed, reported figures vary widely due to differences in handedness classification criteria and subject characteristics. Among those population studies that have used the same handedness classification criteria, a consistent relationship between increasing right-hand preference and increasing age has been reported. One recent study of @entity2 ( @entity2 ) reported a higher incidence of @entity5 in early onset relative to late onset cases. In the present study we examined handedness patterns in three elderly groups; normal (N = 217), @entity4 (N = 73), and @entity2 (N = 114). Our results indicated a reduced frequency of @entity5 in @entity2 (2.6%) relative to control (11.1%) and @entity4 (13.7%) groups. Within the limited age range we studied (60-80 years), no relationships were found between age and handedness preference either within or across the groups. Furthermore, for the @entity2 group there was no relationship between severity of @entity1 and strength of handedness. Our results suggest that compared to right handers, left handers are less vulnerable to the cognitive changes associated with @entity2 . Nevertheless it is also possible that left handers are overrepresented among early onset @entity3 @entity0 and die before entering the pool of @entity2 @entity0 . Further work is required to determine if early and late onset @entity2 are associated with different incidences of @entity5 .

title: Reduced incidence of @entity5 in clinically diagnosed XXXX of the Alzheimer type.

answer: @entity3


abstract: OBJECTIVES: This study evaluated the effect of late dynamization on callus stiffness and size in a @entity1 diaphyseal femoral osteotomy model. It was hypothesized that late dynamization, after bony bridging, would enhance healing. METHODS: The external unilateral fixator was dynamized by removal of the inner fixator bar at either 3 weeks (D3 group) or 4 weeks (D4 group) postoperation. After 5 weeks, the @entity1 were euthanized and healing was evaluated by biomechanical and densitometric methods. Published data of control groups, constant rigid (R group), and flexible fixation (F group) were included for comparison. RESULTS: Enhanced healing was observed in both the 3- and 4-week dynamized groups compared with the constant flexible and constant rigid fixation. Late dynamization after both 3 and 4 weeks postoperation led to a stiffer callus (percent @entity3 relative to the intact side and elastic modulus) with a smaller callus bone volume compared with the F group. Both late dynamized groups (D3 and D4) had a similar @entity3 and bone mineral density as that of the R group. However, the D4 group had a significantly greater elastic modulus and significantly smaller callus bone volume compared with the R group suggesting increased remodeling occurred in the D4 group indicative of more advanced healing. CONCLUSIONS: Late dynamization enhanced @entity2 healing in this animal model compared with a constant rigid or constant flexible fixation. Although results of the small animal study cannot directly be transferred to @entity0 , these results indicate that once bony bridging has occurred, dynamization may accelerate bone remodeling processes.

title: Late dynamization by reduced fixation stiffness enhances XXXX healing in a @entity1 femoral osteotomy model.

answer: @entity2


abstract: OBJECTIVES: This study evaluated the effect of late dynamization on callus stiffness and size in a @entity1 diaphyseal femoral osteotomy model. It was hypothesized that late dynamization, after bony bridging, would enhance healing. METHODS: The external unilateral fixator was dynamized by removal of the inner fixator bar at either 3 weeks (D3 group) or 4 weeks (D4 group) postoperation. After 5 weeks, the @entity1 were euthanized and healing was evaluated by biomechanical and densitometric methods. Published data of control groups, constant rigid (R group), and flexible fixation (F group) were included for comparison. RESULTS: Enhanced healing was observed in both the 3- and 4-week dynamized groups compared with the constant flexible and constant rigid fixation. Late dynamization after both 3 and 4 weeks postoperation led to a stiffer callus (percent @entity3 relative to the intact side and elastic modulus) with a smaller callus bone volume compared with the F group. Both late dynamized groups (D3 and D4) had a similar @entity3 and bone mineral density as that of the R group. However, the D4 group had a significantly greater elastic modulus and significantly smaller callus bone volume compared with the R group suggesting increased remodeling occurred in the D4 group indicative of more advanced healing. CONCLUSIONS: Late dynamization enhanced @entity2 healing in this animal model compared with a constant rigid or constant flexible fixation. Although results of the small animal study cannot directly be transferred to @entity0 , these results indicate that once bony bridging has occurred, dynamization may accelerate bone remodeling processes.

title: Late dynamization by reduced fixation stiffness enhances @entity2 healing in a XXXX femoral osteotomy model.

answer: @entity1


abstract: UNASSIGNED: Background. In 2000, a Zambian private mining company reintroduced the use of @entity4 ( @entity2 ) to control @entity1 in two districts. From 2000 to 2010, @entity2 had been applied in homes without any studies conducted to ascertain its fate in the environment. We aimed to quantify the presence of @entity2 and its metabolites in the soil and water around communities where it was recently used. Methods. We collected superficial soil and water samples from drinking sources of three study areas. @entity2 was extracted by QuEChERS method and solid phase extraction for soils and water, respectively. Analysis was by gas chromatography-mass spectrometry. A revalidated method with limits of detection ranging from 0.034 to 0.04   ppb was used. Results. Median levels of total @entity2 were found at 100.4 (IQR 90.9-110) and 725.4   ng/L (IQR 540-774.5) for soils and water, respectively. No @entity2 above detection limits was detected in the reference area. These results are clinically significant given the persistent characteristics of @entity2 . Conclusion. @entity2 presence in these media suggests possible limitations in the environmental safeguards during @entity3 . Such occurrence could have potential effects on @entity0 , especially @entity0 ; hence, there is a need to further examine possible associations between this exposure and @entity0 .

title: Linking Environmental Exposure with Public Health: XXXX Extracted from Soils and Water of Recently Exposed Communities of Selected Locations in Zambia.

answer: @entity4


abstract: STUDY DESIGN: This study is a cross-sectional, face-to-face interview. OBJECTIVES: To examine the sexual activity in a sample of Malaysian @entity0 with traumatic @entity2 ( @entity2 ), identify the physical and psychological barriers to it, and explore their experiences with sexual counseling and rehabilitation. SETTING: This study was conducted at the Spinal Rehabilitation Unit of a teaching hospital. METHODS: All @entity0 who attended scheduled check-ups, over 1 year, and who met the inclusion criteria (age above 18 years, @entity3 of traumatic aetiology, living in the community and having completed the rehabilitation) were consecutively included in a face-to-face interview using a self-constructed questionnaire. Sociodemographic and disability-related variables, barriers to sexual activity/satisfaction and experiences of sexual rehabilitation services were obtained. RESULTS: During the study period, 33/36 subjects were recruited. Although 67% indicated interest in sexual activity, only 24% was sexually active. The frequency of sexual activity declined after the injury, from 4.6 times per month to 1.5 times per month. Feeling unattractive, unable to satisfy the partner and less confident about sexual ability were top three psychological barriers to sexual activity, and the top three physical barriers were @entity1 , positioning and vaginal lubrication. In all, 50% received some sexual information during rehabilitation. Rehabilitation professionals were expected to initiate sexual counseling by 62.5% of subjects. CONCLUSION: The effect of @entity2 on sexual function is tremendous. Sexual counseling services must be improved and take into account the impact of psychological factors.

title: Barriers to sexual activity: counselling spinal cord injured XXXX in Malaysia.

answer: @entity0


abstract: BACKGROUND: Endoscopic submucosal dissection (ESD) is a promising technique for the treatment of large, pre- and early malignant @entity2 . OBJECTIVE: To assess the rates of en bloc resection, incidence of complications, procedure times and therapeutic outcomes of ESD using an insulated-tip diathermic knife; and to investigate predictors of these outcomes based on the final pathological features of biopsy specimens. METHODS: One hundred twenty @entity0 with endoscopically suspected @entity1 who were treated with ESD from January 2006 to December 2009 were evaluated. RESULTS: The mean diameter of the @entity1 in the present cohort was 1.88 cm. The mean diameter of the resected specimens was 3.33 cm. The en bloc resection rate was 90% (108 of 120). The median length of the operation was 64.6 min. The @entity4 and perforation complication rates were 5.0% (six of 120) and 2.5% (three of 120), respectively. Of 10 @entity1 initially diagnosed as @entity3 on biopsy, four were found to be low-grade @entity5 and six were found to be high-grade @entity5 after resection and final pathological examination. A total of 112 (93.33%) @entity0 underwent curative treatment, eight @entity0 (6.67%) underwent noncurative treatment with ESD, and two @entity0 (1.67%) experienced local recurrence and subsequently underwent surgery. CONCLUSIONS: ESD is a promising local curative treatment option for @entity1 , but still carries the risks of @entity4 and   or perforation. Differences in the interpretation of histological results among different pathologists and   or between biopsy specimens before ESD and the en bloc tissue specimens after ESD will result in discrepancies.

title: Treatment of XXXX by endoscopic submucosal dissection using an insulated-tip diathermic knife.

answer: @entity1


abstract: BACKGROUND AND STUDY AIMS: To evaluate the efficacy of two different @entity3 ( @entity3 ) devices for symptomatic internal @entity3 . @entity0 AND METHODS: From November 2000 to February 2001, 218 consecutive @entity0 with symptomatic @entity3 were enrolled. A total of 109 @entity0 were treated with an @entity3 device 9 mm in diameter (group A); the rest were treated with a device 13 mm in diameter (group B). The @entity0 ' clinical presentations were @entity2 and prolapse. The severity of the @entity3 was classified using Goligher's grading. RESULTS: All @entity0 were treated for one session, and were followed from 19 to 24 months (mean 22.4 months). The number of band ligations averaged 2.59 in group A and 1.68 in group B. Most @entity0 had their @entity3 reduced by at least one grade (82.8 % in group A and 90.8 % in group B). @entity2 was controlled in 108 @entity0 (99.1 %) in group A and 109 @entity0 (100 %) in group B, while rectal prolapse was reduced in 93 @entity0 (85.3 %) in group A and 99 @entity0 (90.8 %) in group B. Eleven @entity0 in group A and 12 in group B experienced @entity1 after treatment, and eight @entity0 in group A and six in group B had mild @entity2 . The @entity0 ' subjective satisfaction rates were 90.8 % in group A and 93.6 % in group B. The 1-year recurrence rates were 3.9 % in group A and 2.3 % in group B. CONCLUSIONS: Both @entity3 devices can effectively treat symptomatic @entity3 . A device with a smaller diameter requires more band ligations, but appears equivalent with regard to treatment outcome and complications.

title: Long-term results of XXXX : two different devices with similar results.

answer: @entity3


abstract: We present results of mutation screening of @entity2 gene in 93 Iranian @entity1 ( @entity1 ) @entity0 with average age at onset (AAO) of 42.2 years. The gene was screened by direct sequencing and by a semi-quantitative PCR protocol for detection of sequence rearrangements. Heterozygous rearrangements were tested by reverse transcription-polymerase chain reaction (RT-PCR). Nine different @entity2 mutations were found. One of these, @entity6 , affects splicing and is novel. Two mutated @entity2 alleles were observed in each of 6 @entity0 whose average AAO was 25.7 years. Only 1 @entity0 carried a single mutated allele and his AAO was 41 years. Among @entity0 with AAO of <30 years, 31.3% had two mutated alleles, while only 2.6% with AAO of >30 years carried a @entity2 mutation. Analysis of @entity2 by RT-PCR led to identification of a novel exon expressed in leukocytes of control and @entity1 individuals. The alternatively spliced transcript if translated would code a protein without a RING Finger 2 domain. Its functional relevance remains to be shown. DJ-I and @entity3 were also screened. Two novel @entity5 mutations, @entity7 affecting splicing and @entity8 causing @entity9 , were observed among @entity0 with AAO of <31 years, suggesting that @entity1 in a high fraction (>12%) of this group of Iranian @entity0 may be due to mutations in @entity5 . Mutations in @entity3 were not observed. Our results complement previous findings on @entity4 mutations among Iranian @entity1 @entity0 .

title: XXXX , @entity5 , and @entity3 screening identifies novel splice site mutation in @entity2 and two novel @entity5 mutations.

answer: @entity2


abstract: We present results of mutation screening of @entity2 gene in 93 Iranian @entity1 ( @entity1 ) @entity0 with average age at onset (AAO) of 42.2 years. The gene was screened by direct sequencing and by a semi-quantitative PCR protocol for detection of sequence rearrangements. Heterozygous rearrangements were tested by reverse transcription-polymerase chain reaction (RT-PCR). Nine different @entity2 mutations were found. One of these, @entity6 , affects splicing and is novel. Two mutated @entity2 alleles were observed in each of 6 @entity0 whose average AAO was 25.7 years. Only 1 @entity0 carried a single mutated allele and his AAO was 41 years. Among @entity0 with AAO of <30 years, 31.3% had two mutated alleles, while only 2.6% with AAO of >30 years carried a @entity2 mutation. Analysis of @entity2 by RT-PCR led to identification of a novel exon expressed in leukocytes of control and @entity1 individuals. The alternatively spliced transcript if translated would code a protein without a RING Finger 2 domain. Its functional relevance remains to be shown. DJ-I and @entity3 were also screened. Two novel @entity5 mutations, @entity7 affecting splicing and @entity8 causing @entity9 , were observed among @entity0 with AAO of <31 years, suggesting that @entity1 in a high fraction (>12%) of this group of Iranian @entity0 may be due to mutations in @entity5 . Mutations in @entity3 were not observed. Our results complement previous findings on @entity4 mutations among Iranian @entity1 @entity0 .

title: @entity2 , @entity5 , and @entity3 screening identifies novel splice site mutation in XXXX and two novel @entity5 mutations.

answer: @entity2


abstract: We present results of mutation screening of @entity2 gene in 93 Iranian @entity1 ( @entity1 ) @entity0 with average age at onset (AAO) of 42.2 years. The gene was screened by direct sequencing and by a semi-quantitative PCR protocol for detection of sequence rearrangements. Heterozygous rearrangements were tested by reverse transcription-polymerase chain reaction (RT-PCR). Nine different @entity2 mutations were found. One of these, @entity6 , affects splicing and is novel. Two mutated @entity2 alleles were observed in each of 6 @entity0 whose average AAO was 25.7 years. Only 1 @entity0 carried a single mutated allele and his AAO was 41 years. Among @entity0 with AAO of <30 years, 31.3% had two mutated alleles, while only 2.6% with AAO of >30 years carried a @entity2 mutation. Analysis of @entity2 by RT-PCR led to identification of a novel exon expressed in leukocytes of control and @entity1 individuals. The alternatively spliced transcript if translated would code a protein without a RING Finger 2 domain. Its functional relevance remains to be shown. DJ-I and @entity3 were also screened. Two novel @entity5 mutations, @entity7 affecting splicing and @entity8 causing @entity9 , were observed among @entity0 with AAO of <31 years, suggesting that @entity1 in a high fraction (>12%) of this group of Iranian @entity0 may be due to mutations in @entity5 . Mutations in @entity3 were not observed. Our results complement previous findings on @entity4 mutations among Iranian @entity1 @entity0 .

title: @entity2 , XXXX , and @entity3 screening identifies novel splice site mutation in @entity2 and two novel @entity5 mutations.

answer: @entity5


abstract: We present results of mutation screening of @entity2 gene in 93 Iranian @entity1 ( @entity1 ) @entity0 with average age at onset (AAO) of 42.2 years. The gene was screened by direct sequencing and by a semi-quantitative PCR protocol for detection of sequence rearrangements. Heterozygous rearrangements were tested by reverse transcription-polymerase chain reaction (RT-PCR). Nine different @entity2 mutations were found. One of these, @entity6 , affects splicing and is novel. Two mutated @entity2 alleles were observed in each of 6 @entity0 whose average AAO was 25.7 years. Only 1 @entity0 carried a single mutated allele and his AAO was 41 years. Among @entity0 with AAO of <30 years, 31.3% had two mutated alleles, while only 2.6% with AAO of >30 years carried a @entity2 mutation. Analysis of @entity2 by RT-PCR led to identification of a novel exon expressed in leukocytes of control and @entity1 individuals. The alternatively spliced transcript if translated would code a protein without a RING Finger 2 domain. Its functional relevance remains to be shown. DJ-I and @entity3 were also screened. Two novel @entity5 mutations, @entity7 affecting splicing and @entity8 causing @entity9 , were observed among @entity0 with AAO of <31 years, suggesting that @entity1 in a high fraction (>12%) of this group of Iranian @entity0 may be due to mutations in @entity5 . Mutations in @entity3 were not observed. Our results complement previous findings on @entity4 mutations among Iranian @entity1 @entity0 .

title: @entity2 , @entity5 , and @entity3 screening identifies novel splice site mutation in @entity2 and two novel XXXX mutations.

answer: @entity5


abstract: We present results of mutation screening of @entity2 gene in 93 Iranian @entity1 ( @entity1 ) @entity0 with average age at onset (AAO) of 42.2 years. The gene was screened by direct sequencing and by a semi-quantitative PCR protocol for detection of sequence rearrangements. Heterozygous rearrangements were tested by reverse transcription-polymerase chain reaction (RT-PCR). Nine different @entity2 mutations were found. One of these, @entity6 , affects splicing and is novel. Two mutated @entity2 alleles were observed in each of 6 @entity0 whose average AAO was 25.7 years. Only 1 @entity0 carried a single mutated allele and his AAO was 41 years. Among @entity0 with AAO of <30 years, 31.3% had two mutated alleles, while only 2.6% with AAO of >30 years carried a @entity2 mutation. Analysis of @entity2 by RT-PCR led to identification of a novel exon expressed in leukocytes of control and @entity1 individuals. The alternatively spliced transcript if translated would code a protein without a RING Finger 2 domain. Its functional relevance remains to be shown. DJ-I and @entity3 were also screened. Two novel @entity5 mutations, @entity7 affecting splicing and @entity8 causing @entity9 , were observed among @entity0 with AAO of <31 years, suggesting that @entity1 in a high fraction (>12%) of this group of Iranian @entity0 may be due to mutations in @entity5 . Mutations in @entity3 were not observed. Our results complement previous findings on @entity4 mutations among Iranian @entity1 @entity0 .

title: @entity2 , @entity5 , and XXXX screening identifies novel splice site mutation in @entity2 and two novel @entity5 mutations.

answer: @entity3


abstract: BACKGROUND: Although the symptoms of unilateral "medically unexplained" or "functional" @entity3 and @entity2 present commonly to neurologists, little is known about their long term prognosis. OBJECTIVE: To determine the long term outcome of @entity3 and @entity2 . @entity0 : A previously assembled cohort of 60 @entity0 seen as inpatients by consultant neurologists in Edinburgh between 1985 and 1992 and diagnosed as having unilateral @entity3 or @entity2 . METHODS: Current symptoms, disability, and distress were assessed by postal questionnaire to the @entity0 and their family doctors. RESULTS: Follow up data relating to mortality were obtained in 56 @entity0 (93%) and to current diagnosis in 48 @entity0 (80%). @entity0 questionnaire data were obtained in 42 @entity0 (70%). The median duration of follow up was 12.5 years (range 9 to 16). Thirty five of the 42 @entity0 (83%) still reported @entity3 or @entity4 , and the majority reported limitation of physical function, distress, and multiple other somatic symptoms. Twenty nine per cent had taken medical retirement. An examination of baseline predictors indicated that @entity0 who had @entity4 had better functioning at follow up than those who had @entity3 . Only one @entity0 had developed a @entity1 which, in hindsight, explained the original presentation. Another @entity0 had died of unrelated causes. CONCLUSIONS: Many @entity0 assessed by neurologists with unilateral @entity3 and @entity4 as inpatients remain symptomatic, distressed, and disabled as long as 12 years after the original diagnosis. These symptoms are only rarely explained by the subsequent development of a recognisable @entity1 in the long term.

title: The 12 year prognosis of unilateral @entity3 and XXXX .

answer: @entity2


abstract: BACKGROUND: Although the symptoms of unilateral "medically unexplained" or "functional" @entity3 and @entity2 present commonly to neurologists, little is known about their long term prognosis. OBJECTIVE: To determine the long term outcome of @entity3 and @entity2 . @entity0 : A previously assembled cohort of 60 @entity0 seen as inpatients by consultant neurologists in Edinburgh between 1985 and 1992 and diagnosed as having unilateral @entity3 or @entity2 . METHODS: Current symptoms, disability, and distress were assessed by postal questionnaire to the @entity0 and their family doctors. RESULTS: Follow up data relating to mortality were obtained in 56 @entity0 (93%) and to current diagnosis in 48 @entity0 (80%). @entity0 questionnaire data were obtained in 42 @entity0 (70%). The median duration of follow up was 12.5 years (range 9 to 16). Thirty five of the 42 @entity0 (83%) still reported @entity3 or @entity4 , and the majority reported limitation of physical function, distress, and multiple other somatic symptoms. Twenty nine per cent had taken medical retirement. An examination of baseline predictors indicated that @entity0 who had @entity4 had better functioning at follow up than those who had @entity3 . Only one @entity0 had developed a @entity1 which, in hindsight, explained the original presentation. Another @entity0 had died of unrelated causes. CONCLUSIONS: Many @entity0 assessed by neurologists with unilateral @entity3 and @entity4 as inpatients remain symptomatic, distressed, and disabled as long as 12 years after the original diagnosis. These symptoms are only rarely explained by the subsequent development of a recognisable @entity1 in the long term.

title: The 12 year prognosis of unilateral XXXX and @entity2 .

answer: @entity3


abstract: OBJECTIVE: To elucidate in vivo hip instability by comparing normal hips to hips with @entity3 by evaluating three-dimensional (3D) translations of the @entity1 ( @entity1 ) at different hip positions using magnetic resonance imaging (MRI). DESIGN: Forty normal hips and 22 @entity2 female hips were examined. MRI was performed at four different positions bilaterally: neutral, 45   of flexion, 15   of extension, and the Patrick position. Femoral and pelvic bones were separately extracted at the neutral position and superimposed over the images of each different position using voxel-based registration. The distance between the acetabular center and @entity1 at neutral position was defined as 3D-migration. The distance between @entity1 at neutral position and that at each different position was defined as 3D-translation. Two-way repeated measures analysis of variance was performed to consider the dependency between right and left-side data, and multiple linear regression analyses were performed to assess independent relationships. RESULTS: The center-edge (CE) angle was the determinant for 3D-migration (b=-0.415, P=0.001), and there was a statistical significant difference in 3D-migration between normal female hips and @entity0 (P=0.047). From neutral to the Patrick position, the @entity1 of normal and @entity0 translated postero-infero-medially by 1.12  0.39mm (0.45-1.85mm) and 1.97  0.84mm (0.95-4.34mm), respectively, and the difference between the groups was statistically significant (P=0.005). CE angle was the determinant for 3D-translation from neutral to the Patrick position (b=-0.730, P<0.001). The average root mean square error in 3D-translation was 0.172mm and 0.193mm for intra- and interobserver reproducibility, respectively. CONCLUSIONS: Hip instability was increased in proportion to the severity of @entity3 . A 3D MRI voxel-based registration technique can show in vivo morphology and kinematics of the native hip without exposure to radioactivity.

title: Evaluation of translation in the normal and XXXX hip using three-dimensional magnetic resonance imaging and voxel-based registration.

answer: @entity2


abstract: The authors reviewed the computed tomographic (CT) scans and pathologic specimens of 57 histologically proved @entity3 (35 @entity6 , 12 @entity8 , and 10 @entity5 ) in 47 @entity0 with @entity7 . The @entity0 ranged in age from 61 to 87 years (mean age, 72 years; 42 @entity0 and 5 @entity0 ). On radiography and CT, most @entity2 (82%) were located in peripheral areas of @entity4 . In 50 of the 57 lesions, the @entity2 were round or lobulated with sharp margins. In seven @entity2 , including six @entity6 and @entity8 , the @entity2 invaded the @entity4 and lacked distinct margins. Intratumor lucency was seen in 13 @entity2 (five solitary and eight multiple). The CT findings, including high-resolution CT scans, were compared with the histologic findings in a subgroup of 29 lesions in 25 @entity0 with available surgical or autopsy specimens. @entity1 with unclear margins (four lesions), septal thickening of the contiguous/surrounding honeycombed areas (16 lesions), and discrete masses (nine lesions) with solitary (four of nine) or multiple (five of nine) intratumor lucencies. The lucencies in six of nine @entity0 (67%) with intratumor lucencies were found to represent engulfed cystic airspaces histologically. CT revealed that @entity3 associated with @entity7 has distinct morphologic characteristics that correlate histologically with a specific pattern of @entity2 growth.

title: Lung cancer associated with XXXX : CT-pathologic correlation.

answer: @entity7


abstract: OBJECTIVE: To evaluate the treatment and clinical outcome of @entity0 with FIGO stage @entity4 @entity2 (SCC). METHODS: Medical records, including 5-year follow-up, were reviewed for 276 @entity0 with stage @entity4 SCC. RESULTS: As definitive surgery, 152 (55.1%), 72 (26.1%), 40 (14.5%), and 12 (4.3%) @entity0 underwent conization, hysterectomy, hysterectomy with pelvic lymphadenectomy (PL), and radical hysterectomy with PL, respectively. Among these groups, the 5-year recurrence-free rate was 94.1%, 98.6%, 95%, and 100%, respectively, and the survival rate was 98.7%, 98.6%, 100%, and 100%, respectively. @entity1 was identified among 12 (4.3%) @entity0 , and was related to the depth of invasion (P<0.001). Eleven (4.0%) of 276 @entity0 were found to have lymph vascular space invasion (LVSI). There were no positive lymph nodes among 52 @entity0 who underwent PL, including those with LVSI. Conization was followed by hysterectomy in 49 @entity0 . In these @entity0 , @entity3 was found in 18 @entity0 , 3 of whom had no involved margins on previous conization. In the group of @entity0 treated by conization, recurrence correlated with the status of the endocervical and lateral cone margin (P<0.001). CONCLUSION: As a conservative approach, conization is an effective and reasonable treatment option for stage @entity4 SCC, especially in actively reproductive @entity0 .

title: Treatment and outcome of stage XXXX squamous cell carcinoma of the uterine cervix.

answer: @entity4


abstract: OBJECTIVE: The prognostic value of microalbuminuria is unsettled in resistant @entity3 . The objective was to evaluate the importance of baseline and serial changes in @entity5 as predictors of @entity2 and mortality in @entity0 with resistant @entity3 . METHODS: 531 resistant hypertensives had urinary albumin excretion rate (UAER) measured prospectively at baseline and at the 2nd year of follow-up. Primary endpoints were a composite of fatal and non-fatal cardiovascular events, all-cause and cardiovascular mortalities. @entity1 and @entity4 ( @entity4 ) events were secondary endpoints. Multiple Cox regression assessed the associations between UAER and endpoints. RESULTS: After a median follow-up of 4.9 years, 72 @entity0 died, 42 from cardiovascular causes; 96 cardiovascular events occurred, 42 @entity1 and 47 @entity4 events. After adjustment for several cardiovascular risk factors, baseline UAER, either analyzed as a continuous variable or dichotomized at different cut-off values, was an independent predictor of the composite endpoint, all-cause and cardiovascular mortality, @entity1 and @entity4 events. Each 10-fold increase in UAER implied a significant 1.6, 1.5, 2.0, 1.5 and 1.6-fold higher risk, respectively, for each of the above endpoints. Serial changes in microalbuminuria status during follow-up tended to parallel changes in cardiovascular risk, regression of microalbuminuria was associated with a 27% lower risk and development with a 65% higher risk of having a cardiovascular event. CONCLUSIONS: Baseline @entity5 strongly predicts @entity2 and mortality in resistant @entity3 @entity0 and serial changes in microalbuminuria may translate into changes in risk. Microalbuminuria reduction may be a goal of anti- @entity3 treatment.

title: Prognostic importance of baseline and serial changes in microalbuminuria in @entity0 with resistant XXXX .

answer: @entity3


abstract: OBJECTIVE: The prognostic value of microalbuminuria is unsettled in resistant @entity3 . The objective was to evaluate the importance of baseline and serial changes in @entity5 as predictors of @entity2 and mortality in @entity0 with resistant @entity3 . METHODS: 531 resistant hypertensives had urinary albumin excretion rate (UAER) measured prospectively at baseline and at the 2nd year of follow-up. Primary endpoints were a composite of fatal and non-fatal cardiovascular events, all-cause and cardiovascular mortalities. @entity1 and @entity4 ( @entity4 ) events were secondary endpoints. Multiple Cox regression assessed the associations between UAER and endpoints. RESULTS: After a median follow-up of 4.9 years, 72 @entity0 died, 42 from cardiovascular causes; 96 cardiovascular events occurred, 42 @entity1 and 47 @entity4 events. After adjustment for several cardiovascular risk factors, baseline UAER, either analyzed as a continuous variable or dichotomized at different cut-off values, was an independent predictor of the composite endpoint, all-cause and cardiovascular mortality, @entity1 and @entity4 events. Each 10-fold increase in UAER implied a significant 1.6, 1.5, 2.0, 1.5 and 1.6-fold higher risk, respectively, for each of the above endpoints. Serial changes in microalbuminuria status during follow-up tended to parallel changes in cardiovascular risk, regression of microalbuminuria was associated with a 27% lower risk and development with a 65% higher risk of having a cardiovascular event. CONCLUSIONS: Baseline @entity5 strongly predicts @entity2 and mortality in resistant @entity3 @entity0 and serial changes in microalbuminuria may translate into changes in risk. Microalbuminuria reduction may be a goal of anti- @entity3 treatment.

title: Prognostic importance of baseline and serial changes in microalbuminuria in XXXX with resistant @entity3 .

answer: @entity0


abstract: INTRODUCTION: @entity9 are enigmatic clinical conditions that may have considerable impact on the social and relational life of @entity0 . @entity0 usually complain of lower @entity3 that has lasted for more than six months, is intermittent or continuous, and may become worse during menses or after a hard day's work. Sometimes the @entity2 is accompanied by @entity5 , urinary urgency or @entity7 . The traditional treatment of @entity4 has included both medical (analgesics, hormones) and surgical approaches (hysterectomy, @entity1 ). Recently, percutaneous transcatheter embolization has also been proposed. We report our experience with the percutaneous management of @entity4 , using the transbrachial approach and @entity8 alone. MATERIAL AND METHODS: Between 1996 and 2001, 33 @entity0 underwent percutaneous treatment for @entity4 at our department. All the @entity0 had @entity6 which was continuous in 69%; 20 @entity0 had @entity5 , whereas 8 had urinary urgency; 72% took analgesics on a regular basis. All the @entity0 underwent percutaneous treatment of @entity4 on a outpatient basis in a radiological suite, after receiving local anaesthesia. Sclerosis was performed with 3% @entity10 . Follow-up consisted of a questionnaire at one month and gynaecological and ultrasound examinations at 6/12 months. RESULTS: The pre-procedural ultrasound examination had revealed a mean diameter of 4.5 mm for the right ovarian vein and of 6.3 mm for the left. We found one @entity4 on the right, 11 on the left and 21 bilaterally. At the one-month follow-up, @entity6 was present in 13 @entity0 (39%); the @entity2 was continuous in three and intermittent in ten. At the follow-up after 6/12 months the symptoms were unchanged. Ultrasound revealed a reduction in periovarian varicosities, recording a mean diameter of 3.19 mm on the right and 4.5 mm on the left. Symptoms persisted in @entity0 with pelvic varicosities measuring over 5 mm at ultrasound. CONCLUSIONS: @entity9 that do not respond to medical therapy can be resolved by percutaneous management. Less expensive than surgery, this therapeutic option is safe, effective, minimally invasive and capable of restoring @entity0 to normal function. We propose the transbrachial approach as the first-choice treatment for bilateral @entity4 .

title: Percutaneous treatment of XXXX .

answer: @entity4


abstract: OBJECTIVE: To assess the efficacy and safety of a low calorie soy-based meal replacement program for the treatment of @entity1 . DESIGN: A 12-week prospective randomized controlled clinical trial. SETTING: Outpatient weight control research unit. SUBJECTS: One @entity1 (28<BMI<or=41 kg/m(2)) volunteers between the ages of 35 and 65 y. Seventy-four @entity0 completed the trial. INTERVENTION: @entity0 were randomized to either the meal replacement treatment group (n=50; 240 g/day, 1200 kcal/day) or control group (n=50). Both groups at baseline received a single dietary counseling session and a pamphlet describing @entity3 practices. MAIN OUTCOME MEASURES: Weight, body fat, serum lipid concentrations. RESULTS: : By intent-to-treat analysis, the treatment group lost significantly more weight than the control group (7.00 vs 2.90 kg; P<0.001) and had a greater change in total (22.5 vs 6.8 mg/dl; P=0.013) and LDL @entity2 (21.2 vs 7.1 mg/dl; P<0.009). Among completers only, the treatment group again lost more weight (7.1 kg; n=37 vs 2.9 kg; n=37; P=0.0001) and had a greater reduction in total @entity2 (26.1 mg/dl; n=37 vs 6.7 mg/dl; P=0.0012) and a greater change in LDL @entity2 (21.6 vs 5.5 mg/dl; P=0.0025). (For any given degree of @entity3 , the reduction in LDL @entity2 was significantly greater in the treatment group.) Treatment was well tolerated and no serious side effects were detected. CONCLUSIONS: Use of this soy-based meal replacement formula was effective in lowering body weight, fat mass and in reducing LDL @entity2 beyond what could be expected given the weight lost.

title: A novel soy-based meal replacement formula for XXXX among @entity1 individuals: a randomized controlled clinical trial.

answer: @entity3


abstract: OBJECTIVE: To assess the efficacy and safety of a low calorie soy-based meal replacement program for the treatment of @entity1 . DESIGN: A 12-week prospective randomized controlled clinical trial. SETTING: Outpatient weight control research unit. SUBJECTS: One @entity1 (28<BMI<or=41 kg/m(2)) volunteers between the ages of 35 and 65 y. Seventy-four @entity0 completed the trial. INTERVENTION: @entity0 were randomized to either the meal replacement treatment group (n=50; 240 g/day, 1200 kcal/day) or control group (n=50). Both groups at baseline received a single dietary counseling session and a pamphlet describing @entity3 practices. MAIN OUTCOME MEASURES: Weight, body fat, serum lipid concentrations. RESULTS: : By intent-to-treat analysis, the treatment group lost significantly more weight than the control group (7.00 vs 2.90 kg; P<0.001) and had a greater change in total (22.5 vs 6.8 mg/dl; P=0.013) and LDL @entity2 (21.2 vs 7.1 mg/dl; P<0.009). Among completers only, the treatment group again lost more weight (7.1 kg; n=37 vs 2.9 kg; n=37; P=0.0001) and had a greater reduction in total @entity2 (26.1 mg/dl; n=37 vs 6.7 mg/dl; P=0.0012) and a greater change in LDL @entity2 (21.6 vs 5.5 mg/dl; P=0.0025). (For any given degree of @entity3 , the reduction in LDL @entity2 was significantly greater in the treatment group.) Treatment was well tolerated and no serious side effects were detected. CONCLUSIONS: Use of this soy-based meal replacement formula was effective in lowering body weight, fat mass and in reducing LDL @entity2 beyond what could be expected given the weight lost.

title: A novel soy-based meal replacement formula for @entity3 among XXXX individuals: a randomized controlled clinical trial.

answer: @entity1


abstract: BACKGROUND: Several types of epidermal keratinocytic nevus are recognized. OBJECTIVE: We sought to describe a previously unreported keratinocytic nevus with distinctive clinical and histopathologic features in 5 @entity0 . METHODS: We performed a clinical and photographic review, and obtained skin biopsy samples for histopathologic examination from each @entity0 . Genetic analysis to screen for @entity1 and @entity3 3-kinase, catalytic, alpha hotspot mutations was performed on lesional skin from two @entity0 . RESULTS: Five @entity0 (2 male, 3 female) had from 1 to 11 lesions present since birth. These consisted of 1- to 7-mm hyperkeratotic papules with a rough, flat surface and a round, commalike, rectangular, or polygonal shape. Histopathologic examination showed acanthosis with @entity2 , and strikingly arranged basal cells with palisaded nuclei. Genetic testing on paraffin-embedded specimens from two @entity0 ruled out hotspot mutations in the @entity1 and @entity3 3-kinase, catalytic, alpha genes. LIMITATIONS: A small number of @entity0 are presented. CONCLUSION: We propose the name "papular @entity4 with 'skyline' basal cell layer" (PENS) for this newly recognized condition.

title: Papular XXXX with "skyline" basal cell layer (PENS).

answer: @entity4


abstract: Transthoracic echocardiography (TTE) is a powerful non-invasive diagnostic, monitoring and measurement device in medicine. In addition to cardiologists, many other specialised groups, including emergency and critical care physicians and cardiac anaesthetists, have recognised its ability to provide high quality information and utilise TTE in the care of their @entity0 . In obstetric anaesthesia and management of obstetric @entity3 , the favourable characteristics of pregnant @entity0 facilitate TTE examination. These include anterior and left lateral displacement of the heart, frequent employment of the left lateral tilted position to avoid aortocaval compression, spontaneous ventilation and wide acceptance of ultrasound technology by @entity0 . Of relevance to obstetric anaesthetists is that maternal morbidity and mortality due to @entity1 is significant worldwide. This makes TTE an appropriate, important and applicable device in pregnant @entity0 . Clinician-performed TTE enables differentiation between the life-threatening causes of @entity2 . In the critically ill @entity0 this improves diagnostic accuracy and allows treatment interventions to be instituted and monitored at the point of @entity0 care. This article outlines the application of TTE in the specialty of obstetric anaesthesia and in the management of obstetric @entity3 . It describes the importance of TTE education, quality assurance and outcome recording. It also discusses how barriers to the routine implementation of TTE in obstetric anaesthesia and management of obstetric @entity3 can be overcome.

title: Transthoracic echocardiography in obstetric anaesthesia and obstetric XXXX .

answer: @entity3


abstract: UNASSIGNED: Cutaneous evaporative heat loss in @entity2 and @entity0 has been well documented. Nonetheless, how crossbreds with different fractional genetic proportions respond to such circumstances is of interest. A study to examine the physiological responses to cutaneous evaporative heat loss, also lactation period and milk yield, were conducted in Sahiwal ( @entity2 , n = 10, 444  64.8 kg, 9  2.9 years), Holstein Friesian ( @entity0 , HF100% (n = 10, 488  97.9 kg, 6  2.8 years)) and the following crossbreds: HF50% (n = 10, 355  40.7 kg, 2  0 years) and HF87.5% (n = 10, 489  76.8 kg, 7  1.8 years). They were allocated so as to determine the physiological responses of sweating rate (SR), respiration rate (RR), @entity1 ( @entity1 ), and skin temperature (ST) with and without hair from 06:00 h am to 15:00 h pm. And milk yield during 180 days were collected at days from 30 to 180. The ambient temperature-humidity-index (THI) increased from less than 80 in the early morning to more than 90 in the late afternoon. The interaction of THI and breed were highly affected on SR, RR, @entity1 , and ST (p<0.01). The SR was highest in Sahiwal (595 g/m(2)/h) compared to HF100% (227 g/m(2)/h), and their crossbreds both HF50% (335 g/m(2)/h) and HF87.5% (299 g/m(2)/h). On the other hand, RR was higher in HF87.5% (54 bpm) and both HF100% (48 bpm) and HF50% (42 bpm) than Sahiwal (25 bpm) (p<0.01). The @entity1 showed no significant differences as a result of breed (p>0.05) but did change over time. The ST with and without hair were similar, and was higher in HF100% (37.4  C; 38.0  C) and their crossbred HF50% (35.5  C; 35.5  C) and HF87.5% (37.1  C; 37.9  C) than Sahiwal (34.8  C; 34.8  C) (p<0.01). Moreover, the early lactation were higher at HF100% (25 kg) and 87.5% (25 kg) than HF50% (23 kg) which were higher than Sahiwal (18 kg) while the peak period of lactation was higher at HF100% (35 kg) than crossbreds both HF87.5% and HF50% (32 kg) which was higher than Sahiwal (26 kg) (p<0.05). In conclusion, sweating and respiration were the main vehicle for dissipating excess body heat for Sahiwal, HF and crossbreds, respectively. The THI at 76 to 80 were the critical points where the physiological responses to elevated temperature displayed change.

title: Physiological Responses and Lactation to Cutaneous Evaporative Heat Loss in XXXX , @entity0 , and Their Crossbreds.

answer: @entity2


abstract: UNASSIGNED: Cutaneous evaporative heat loss in @entity2 and @entity0 has been well documented. Nonetheless, how crossbreds with different fractional genetic proportions respond to such circumstances is of interest. A study to examine the physiological responses to cutaneous evaporative heat loss, also lactation period and milk yield, were conducted in Sahiwal ( @entity2 , n = 10, 444  64.8 kg, 9  2.9 years), Holstein Friesian ( @entity0 , HF100% (n = 10, 488  97.9 kg, 6  2.8 years)) and the following crossbreds: HF50% (n = 10, 355  40.7 kg, 2  0 years) and HF87.5% (n = 10, 489  76.8 kg, 7  1.8 years). They were allocated so as to determine the physiological responses of sweating rate (SR), respiration rate (RR), @entity1 ( @entity1 ), and skin temperature (ST) with and without hair from 06:00 h am to 15:00 h pm. And milk yield during 180 days were collected at days from 30 to 180. The ambient temperature-humidity-index (THI) increased from less than 80 in the early morning to more than 90 in the late afternoon. The interaction of THI and breed were highly affected on SR, RR, @entity1 , and ST (p<0.01). The SR was highest in Sahiwal (595 g/m(2)/h) compared to HF100% (227 g/m(2)/h), and their crossbreds both HF50% (335 g/m(2)/h) and HF87.5% (299 g/m(2)/h). On the other hand, RR was higher in HF87.5% (54 bpm) and both HF100% (48 bpm) and HF50% (42 bpm) than Sahiwal (25 bpm) (p<0.01). The @entity1 showed no significant differences as a result of breed (p>0.05) but did change over time. The ST with and without hair were similar, and was higher in HF100% (37.4  C; 38.0  C) and their crossbred HF50% (35.5  C; 35.5  C) and HF87.5% (37.1  C; 37.9  C) than Sahiwal (34.8  C; 34.8  C) (p<0.01). Moreover, the early lactation were higher at HF100% (25 kg) and 87.5% (25 kg) than HF50% (23 kg) which were higher than Sahiwal (18 kg) while the peak period of lactation was higher at HF100% (35 kg) than crossbreds both HF87.5% and HF50% (32 kg) which was higher than Sahiwal (26 kg) (p<0.05). In conclusion, sweating and respiration were the main vehicle for dissipating excess body heat for Sahiwal, HF and crossbreds, respectively. The THI at 76 to 80 were the critical points where the physiological responses to elevated temperature displayed change.

title: Physiological Responses and Lactation to Cutaneous Evaporative Heat Loss in @entity2 , XXXX , and Their Crossbreds.

answer: @entity0


abstract: PURPOSE: To develop a unique skin safety model (SSM) that offers a new and unified perspective on the diverse yet interconnected antecedents that contribute to a spectrum of potential @entity1 in older hospitalized adults. ORGANIZING CONSTRUCT: Discussion paper. METHODS: A literature search of electronic databases was conducted for published articles written in English addressing skin integrity and iatrogenic @entity1 in elderly hospital @entity0 between 1960 and 2014. FINDINGS: There is a multiplicity of literature outlining the etiology, prevention, and management of specific @entity1 . Complex and interrelated factors contribute to iatrogenic @entity1 in the older adult, including multiple comorbidities, factors influencing healthcare delivery, and acute situational stressors. A range of injuries can result when these factors are complicated by skin irritants, pressure, shear, or friction; however, despite @entity1 sharing multiple antecedents, no unified overarching skin safety conceptual model has been published. CONCLUSIONS: The SSM presented in this article offers a new, unified framework that encompasses the spectrum of antecedents to skin vulnerability as well as the spectrum of @entity1 that may be sustained by older acute care @entity0 . Current skin integrity frameworks address prevention and management of specific @entity1 . In contrast, the SSM recognizes the complex interplay of @entity0 and system factors that may result in a range of @entity1 . Skin safety is reconceptualized into a single model that has the potential for application at the individual @entity0 level, as well as healthcare systems and governance levels. CLINICAL RELEVANCE: Skin safety is concerned with keeping skin safe from any iatrogenic @entity1 , and remains an ongoing challenge for healthcare providers. A conceptual framework that encompasses all of the factors that may contribute to a range of @entity1 is essential, and guides the clinician in maintaining skin integrity in the vulnerable older @entity0 .

title: The Skin Safety Model: Reconceptualizing Skin Vulnerability in Older XXXX .

answer: @entity0


abstract: BACKGROUND/AIMS: The prognosis of @entity2 ( @entity2 ) remains unclear. We investigated the prognosis of @entity0 with @entity2 based on the treatments and prognostic factors associated with long-term survival. METHODS: The prognoses of 64 consecutive @entity0 treated for @entity2 from 1986 to 2013 were analyzed according to their methods of treatment. The prognostic factors of 16 surgical @entity0 were identified, and their @entity3 ( @entity3 ) and recurrence rates were compared to 1,157 surgical @entity0 who underwent surgery for non- @entity2 . The surgical outcomes were also compared using a propensity score matching method. RESULTS: Surgery was associated with a better @entity3 . Curative resection was the only independent prognostic factor in surgical @entity0 with @entity2 (p = 0.040). Although the @entity3 of surgical @entity0 with non- @entity2 was found to be significantly better than that of the @entity0 with @entity2 , no significant difference in @entity3 was observed after propensity score matching. CONCLUSION: A curative resection should be the objective of treatment, assuming the suitability of the @entity0 's clinical condition. When the liver function reserve and @entity1 extension of @entity0 with ruptured and non- @entity2 are similar, then their surgical outcomes may not be significantly different.

title: An Analysis of Surgical Treatment for the Spontaneous Rupture of XXXX .

answer: @entity2