abstract: In 1979 and 1980, at the University Hospital Department of Gynecology and Obstetrics, 115 @entity0 with extrauterine pregnancy were surgically treated. In 26 @entity0 the value of the radioimmunologic determination of @entity1 in the serum was analysed. Along with it, also other clinicodiagnostic procedures (immunochemical test for pregnancy, culdocentesis, curettage) wire carried out. Not in a single case of extrauterine pregnancy in which the serum beta @entity1 level was determined, was the result falsely negative. The immunochemical test for pregnancy was falsely negative in 32.6% and the result of culdocentesis was falsely negative in 13.6% of the @entity0 examined. In @entity0 with negative culdocentesis laparoscopy was performed (10.4%), showing ectopic pregnancy. In the course of extrauterine pregnancy the elimination of beta @entity1 was significatly reduced in relation to its level in normal pregnancy. The concentration of beta @entity1 in the observed @entity0 with extrauterine pregnancy ranged from 27 to 3924 IU/L. On the basis of a low beta @entity1 concentration in the serum it is possible to determine with much certainty that pregnancy is not quite normal. Of great help is the observation of changes in the elimination of this hormone over a short period of time. A timely diagnosis of extrauterine pregnancy improves prognosis of future fertility.

title: [ XXXX beta chorionic gonadotropin in the early diagnosis of extrauterine pregnancy].

answer: @entity0


abstract: The paper is devoted to the functional specification and the architecture of a data processing system to database generation and management within the Centre of Nutrition and @entity1 in Bucharest. The main operations performed by the system refer to: -- @entity0 admission. A @entity0 file which is created for any new @entity0 , contains all the details hitherto included in the @entity0 registration form. --File update, carried out periodically or whenever required. Any new relevant detail is added to the existing file in a conversational manner. --Report generation. The reports are produced periodically or upon request. --Inventory and stock control concerning the drugs dispensed free of charge. --Data processing and classification. --Creation and retrieval of @entity0 archives. --Display on request of the various details contained by the @entity0 file. The described system can be implemented on an INDEPENDENT I-100 general purpose minicomputer, having a main memory of 96 kwords. The disc-based AMS operating system is used. The system operates in real time, although off-line background jobs can be run in order to assist the scientific work. A FORTRAN compiler is part of the operating system.

title: Data processing system for the Centre of Nutrition and XXXX .

answer: @entity1


abstract: BACKGROUND: The @entity10 / @entity9 /amnionless complex is essential for albumin and low molecular weight (LMW) protein reabsorption by renal proximal tubules (PT). Mutations of the @entity10 gene encoding @entity10 cause @entity1 (DB/FOAR), which is characterized by LMW @entity2 . The pathophysiology of DB/FOAR-associated @entity7 remains unclear. CLINICAL CASE: A 3-year-old @entity0 presented with @entity3 and @entity2 . Clinical examination was unremarkable, except for a still-opened anterior fontanel and @entity6 . Psychomotor development was delayed. At 6, she developed @entity4 . @entity8 was noted when she turned 12. Blood analyses, including renal function parameters, were normal. Urine sediment was bland. @entity2 was significant and included albumin and LMW proteins. Immunoblotting analyses detected @entity9 and @entity5 ) in the urine. Renal ultrasound was unremarkable. Optical examination of a renal biopsy did not disclose any tubular or glomerular abnormality. Electron microscopy revealed that PT apical endocytic apparatus was significantly less developed. Immunostaining for @entity10 showed a faint signal in PT cytosol contrasting with the distribution of @entity9 at the apical membrane. The diagnostic procedure led to identifying two mutations of the @entity10 gene. CONCLUSIONS: The functional loss of @entity10 in DB/FOAR causes @entity7 characterized by increased urinary shedding of @entity5 and @entity9 .

title: In-depth phenotyping of a Donnai-Barrow XXXX helps clarify proximal tubule dysfunction.

answer: @entity0


abstract: @entity3 occurs frequently in newborn @entity0 with @entity2 , but the exact mechanism remains obscure in those @entity0 who do not have evidence of disseminated @entity6 . Since recent work has suggested a possible immune mechanism for @entity3 observed in adults with @entity2 , we have investigated the role of platelet-associated immunoglobulin in @entity1 . To detect PAIgG we use a method employing protein A and peroxidase-antiperoxidase as a labeled antibody. PAIgG was quantitated by phase contrast microscopy and expressed as a reactive index. Our control group included 16 normal newborn @entity0 whose mean RI was 0.65 +/- 0.01 SE. In addition to the control group, five @entity0 with nonimmune @entity3 were included; their mean RI was 0.66 +/- 0.01 SE. Seventeen newborn @entity0 with severe @entity1 were assayed for PAIgG. Eight of nine @entity0 with @entity5 had increased RI, with a mean of 1.16 +/- 0.03 SE (P less than 0.01). Six of the eight @entity0 with @entity4 had elevated RI, with a mean of 1.23 +/- 0.03 SE (P less than 0.01). These findings suggest that an immune mechanism may be involved in the @entity3 of severe @entity1 .

title: Immune XXXX in @entity1 .

answer: @entity3


abstract: @entity3 occurs frequently in newborn @entity0 with @entity2 , but the exact mechanism remains obscure in those @entity0 who do not have evidence of disseminated @entity6 . Since recent work has suggested a possible immune mechanism for @entity3 observed in adults with @entity2 , we have investigated the role of platelet-associated immunoglobulin in @entity1 . To detect PAIgG we use a method employing protein A and peroxidase-antiperoxidase as a labeled antibody. PAIgG was quantitated by phase contrast microscopy and expressed as a reactive index. Our control group included 16 normal newborn @entity0 whose mean RI was 0.65 +/- 0.01 SE. In addition to the control group, five @entity0 with nonimmune @entity3 were included; their mean RI was 0.66 +/- 0.01 SE. Seventeen newborn @entity0 with severe @entity1 were assayed for PAIgG. Eight of nine @entity0 with @entity5 had increased RI, with a mean of 1.16 +/- 0.03 SE (P less than 0.01). Six of the eight @entity0 with @entity4 had elevated RI, with a mean of 1.23 +/- 0.03 SE (P less than 0.01). These findings suggest that an immune mechanism may be involved in the @entity3 of severe @entity1 .

title: Immune @entity3 in XXXX .

answer: @entity1


abstract: RATIONALE: High demand for @entity1 ( @entity1 ) services and limited bed availability have prompted hospitals to address capacity planning challenges. Simulation modeling can examine @entity1 bed assignment policies, accounting for @entity0 acuity, to reduce @entity1 admission delays. OBJECTIVES: To provide a framework for data-driven modeling of @entity1 @entity0 flow, identify key measurable outcomes, and present illustrative analysis demonstrating the impact of various bed allocation scenarios on outcomes. METHODS: A description of key inputs for constructing a queuing model was outlined, and an illustrative simulation model was developed to reflect current triage protocol within the medical @entity1 and step-down unit (SDU) at a single tertiary-care hospital. @entity0 acuity, arrival rate, and unit length of stay, consisting of a "service time" and "time to transfer," were estimated from 12 months of retrospective data (n   =   2,710 adult @entity0 ) for 36 @entity1 and 15 SDU staffed beds. @entity0 priority was based on acuity and whether the @entity0 originated in the emergency department. The model simulated the following hypothetical scenarios: (1) varied @entity1 /SDU sizes, (2) reserved @entity1 beds as a triage strategy, (3) lower targets for time to transfer out of the @entity1 , and (4) @entity1 expansion by up to four beds. Outcomes included @entity1 admission wait times and unit occupancy. MEASUREMENTS AND MAIN RESULTS: With current bed allocation, simulated wait time averaged 1.13 (SD, 1.39) hours. Reallocating all SDU beds as @entity1 decreased overall wait times by 7.2% to 1.06 (SD, 1.39) hours and increased bed occupancy from 80 to 84%. Reserving the last available bed for acute @entity0 reduced wait times for acute @entity0 from 0.84 (SD, 1.12) to 0.31 (SD, 0.30) hours, but tripled subacute @entity0 ' wait times from 1.39 (SD, 1.81) to 4.27 (SD, 5.44) hours. Setting transfer times to wards for all @entity1 /SDU @entity0 to 1 hour decreased wait times for incoming @entity1 @entity0 , comparable to building one to two additional @entity1 beds. CONCLUSIONS: Hospital queuing and simulation modeling with empiric data inputs can evaluate how changes in @entity1 bed assignment could impact unit occupancy levels and @entity0 wait times. Trade-offs associated with dedicating resources for acute @entity0 versus expanding capacity for all @entity0 can be examined.

title: A Conceptual Framework for Improving Critical Care XXXX Flow and Bed Use.

answer: @entity0


abstract: Isolated circulatory or longitudinally oriented strips from anterior or posterior @entity0 bladder base were tested for responsiveness to agonists and sensitivity of field stimulation-induced responses to antagonists. Results were compared to the regional distribution of adrenergic and cholinergic nerves determined histochemically. Greater @entity1 -induced responses in posterior than in anterior strips reflect denser noradrenergic innervation in posterior base. Longitudinal strips responded better to @entity5 than circular strips, but no orientation-related differences in cholinergic nerve density or muscle mass were noted. Field stimulation-induced contractions were largely resistant to @entity4 (0.03 microM) and @entity2 (100 microM) and slightly reduced by @entity6 (2.6 microM). @entity3 (0.4 microM) reduced maximum responses by 25 to 75%. The resistance to @entity2 suggests that the ineffectiveness of @entity4 is not due solely to atypical post synaptic receptors. Inaccessibility of the synaptic cleft to @entity2 is unlikely because the @entity7 , which possesses close contacts, was sensitive to @entity2 . Neurotransmission in bladder base may be partially noradrenergic, noncholinergic in nature. A question arises concerning the functional significance of the noradrenergic nerves in bladder base.

title: Paradoxical resistance to adrenolytic agents of field-stimulated bladder base of XXXX .

answer: @entity0


abstract: PURPOSE: The purpose of this study was to evaluate change in computed tomography (CT) value of condyle and @entity1 ( @entity1 ) disc position after sagittal split ramus osteotomy (SSRO) setback surgery, retrospectively. SUBJECTS AND METHODS: The subjects were 76 @entity0 (152 condyles) who underwent bilateral SSRO setback surgery. They were divided into 2 groups (43 symmetric @entity0 and 33 asymmetric @entity0 ). CT values (pixel values) of 5 sites of the condyle and condylar width, length, horizontal angle were measured pre-operatively and 1 year post-operatively. Disc position was classified as anterior disc displacement, anterior type, fully covered type and posterior type, preoperatively and postoperatively using magnetic resonance imaging (MRI). RESULTS: In maximum CT value at the center of the condyle, post-operative value was significantly lower than pre-operative value bilaterally (Deviation side: P  =  0.0003, Non-deviation side: P  =  0.0003) in asymmetry group. In minimum CT value at the center of the condyle, the post-operative value was significantly lower than the pre-operative value bilaterally (Deviation side: P  =  0.0309, Non-deviation side: P  =  0.0004) in the symmetry group. With regard to maximum CT value at the lateral site of the condyle in the deviation side, the value for the anterior disc displacement group was significantly larger than that of the posterior type pre-operatively (P  =  0.0123). CT value of the anterior disc displacement group was significantly larger than those of some other areas pre- and post-operatively (P  <  0.05). CONCLUSION: This study suggested that CT value of condylar bone changes after 1 year in SSRO and anterior disc displacement may partially affect the CT value of the condyle in the @entity1 in mandibular prognathism @entity0 .

title: Changes in computed tomography values of mandibular condyle and XXXX disc position after sagittal split ramus osteotomy.

answer: @entity1


abstract: OBJECTIVE: @entity5 at the gastro-oesophageal junction (GOJ) are currently stratified by @entity1 location. This retrospective study examines the association of @entity6 and @entity4 at different locations and compares them with nonjunctional @entity4 . @entity0 AND METHODS: A total of 520 @entity0 with junctional and nonjunctional @entity4 were assessed for the presence and degree of @entity7 , glandular @entity3 and @entity2 in the stomach. Histopathological data were complete for 428 @entity0 (68.9% @entity0 , median age 67.7 years), including 172 @entity0 with @entity1 (GOJ1: 1-5   cm proximal to the junction, GOJ2: 'true' junctional, GOJ3: 2-5   cm distal to the junction). @entity4 and @entity6 were scored according to the updated Sydney classification and further stratified into respective operative link on @entity8 assessment (OLGA) and operative link on @entity8 assessment on @entity7 (OLGIM) stages. RESULTS: The prevalence and degree of @entity4 and @entity7 were significantly lower in GOJ1 than GOJ3 (P<0.01). @entity6 in the stomach were similar in GOJ3 compared with nonjunctional @entity4 . GOJ1 were almost exclusively (98.4%) of the intestinal type, whereas GOJ2 and GOJ3 were the diffuse type in 22.6 and 22.4% of the @entity0 (P<0.001). Of all @entity0 , only 8.5 and 12.7% presented with stage III/IV according to OLGA and OLGIM, respectively. However, data for OLGA and OLGIM staging were only available in 61.2 and 67.9% of @entity0 , respectively. CONCLUSION: GOJ1 are less likely to be associated with gastric pathology compared with GOJ3 or nonjunctional @entity4 . OLGA or OLGIM staging in @entity0 with @entity1 seems to be of limited value.

title: XXXX at different positions at the gastro-oesophageal junction show distinct association with @entity8 and gastric @entity6 .

answer: @entity5


abstract: OBJECTIVE: @entity5 at the gastro-oesophageal junction (GOJ) are currently stratified by @entity1 location. This retrospective study examines the association of @entity6 and @entity4 at different locations and compares them with nonjunctional @entity4 . @entity0 AND METHODS: A total of 520 @entity0 with junctional and nonjunctional @entity4 were assessed for the presence and degree of @entity7 , glandular @entity3 and @entity2 in the stomach. Histopathological data were complete for 428 @entity0 (68.9% @entity0 , median age 67.7 years), including 172 @entity0 with @entity1 (GOJ1: 1-5   cm proximal to the junction, GOJ2: 'true' junctional, GOJ3: 2-5   cm distal to the junction). @entity4 and @entity6 were scored according to the updated Sydney classification and further stratified into respective operative link on @entity8 assessment (OLGA) and operative link on @entity8 assessment on @entity7 (OLGIM) stages. RESULTS: The prevalence and degree of @entity4 and @entity7 were significantly lower in GOJ1 than GOJ3 (P<0.01). @entity6 in the stomach were similar in GOJ3 compared with nonjunctional @entity4 . GOJ1 were almost exclusively (98.4%) of the intestinal type, whereas GOJ2 and GOJ3 were the diffuse type in 22.6 and 22.4% of the @entity0 (P<0.001). Of all @entity0 , only 8.5 and 12.7% presented with stage III/IV according to OLGA and OLGIM, respectively. However, data for OLGA and OLGIM staging were only available in 61.2 and 67.9% of @entity0 , respectively. CONCLUSION: GOJ1 are less likely to be associated with gastric pathology compared with GOJ3 or nonjunctional @entity4 . OLGA or OLGIM staging in @entity0 with @entity1 seems to be of limited value.

title: @entity5 at different positions at the gastro-oesophageal junction show distinct association with XXXX and gastric @entity6 .

answer: @entity8


abstract: OBJECTIVE: @entity5 at the gastro-oesophageal junction (GOJ) are currently stratified by @entity1 location. This retrospective study examines the association of @entity6 and @entity4 at different locations and compares them with nonjunctional @entity4 . @entity0 AND METHODS: A total of 520 @entity0 with junctional and nonjunctional @entity4 were assessed for the presence and degree of @entity7 , glandular @entity3 and @entity2 in the stomach. Histopathological data were complete for 428 @entity0 (68.9% @entity0 , median age 67.7 years), including 172 @entity0 with @entity1 (GOJ1: 1-5   cm proximal to the junction, GOJ2: 'true' junctional, GOJ3: 2-5   cm distal to the junction). @entity4 and @entity6 were scored according to the updated Sydney classification and further stratified into respective operative link on @entity8 assessment (OLGA) and operative link on @entity8 assessment on @entity7 (OLGIM) stages. RESULTS: The prevalence and degree of @entity4 and @entity7 were significantly lower in GOJ1 than GOJ3 (P<0.01). @entity6 in the stomach were similar in GOJ3 compared with nonjunctional @entity4 . GOJ1 were almost exclusively (98.4%) of the intestinal type, whereas GOJ2 and GOJ3 were the diffuse type in 22.6 and 22.4% of the @entity0 (P<0.001). Of all @entity0 , only 8.5 and 12.7% presented with stage III/IV according to OLGA and OLGIM, respectively. However, data for OLGA and OLGIM staging were only available in 61.2 and 67.9% of @entity0 , respectively. CONCLUSION: GOJ1 are less likely to be associated with gastric pathology compared with GOJ3 or nonjunctional @entity4 . OLGA or OLGIM staging in @entity0 with @entity1 seems to be of limited value.

title: @entity5 at different positions at the gastro-oesophageal junction show distinct association with @entity8 and gastric XXXX .

answer: @entity6


abstract: UNASSIGNED: Background and study aims: @entity7 (LM), @entity2 , is a safe antispasmodic agent used during esophagogastroduodenoscopy (EGD). However, it seems to affect gastric mucosal endoscopic findings. Therefore, we evaluated whether LM causes specific changes and impacts the endoscopic morphology of @entity4 . @entity0 and methods: A total of 98 @entity0 scheduled to undergo EGD were randomly assigned to receive LM solution (160mg of 0.8% LM added to 2.5mL of indigo carmine [IC]; n=49; LM group) or decuple-diluted IC solution without LM (n=49; placebo group). We compared the incidence of specific mucosal changes and the difference in the endoscopic findings of several @entity4 between these groups. Results: Annular-reticular - like mucosal changes appeared immediately after the administration of LM solution. This change was observed in 71.4% of the LM group compared with 12.2% of the placebo group (P<0.01). In the placebo group, this change was observed in 14.7% of subjects with @entity6 compared with 6.7% of those without @entity6 (P=0.39), whereas in the LM group, this change was observed in 84.8% of subjects with @entity6 compared with 43.8% of those without @entity6 (P<0.01). Most early @entity2 , @entity5 , and @entity3 observed in this study became well demarcated after LM administration, although the incidence of @entity4 did not differ significantly between the two groups. Conclusion: LM changes the gastric mucosa into @entity1 , and this occurs more frequently in @entity2 than in pathologic lesions. LM may facilitate the demarcation of pathologic @entity4 without intestinal metaplasia.

title: XXXX sprayed on gastric mucosa causes @entity1 change.

answer: @entity7


abstract: UNASSIGNED: Background and study aims: @entity7 (LM), @entity2 , is a safe antispasmodic agent used during esophagogastroduodenoscopy (EGD). However, it seems to affect gastric mucosal endoscopic findings. Therefore, we evaluated whether LM causes specific changes and impacts the endoscopic morphology of @entity4 . @entity0 and methods: A total of 98 @entity0 scheduled to undergo EGD were randomly assigned to receive LM solution (160mg of 0.8% LM added to 2.5mL of indigo carmine [IC]; n=49; LM group) or decuple-diluted IC solution without LM (n=49; placebo group). We compared the incidence of specific mucosal changes and the difference in the endoscopic findings of several @entity4 between these groups. Results: Annular-reticular - like mucosal changes appeared immediately after the administration of LM solution. This change was observed in 71.4% of the LM group compared with 12.2% of the placebo group (P<0.01). In the placebo group, this change was observed in 14.7% of subjects with @entity6 compared with 6.7% of those without @entity6 (P=0.39), whereas in the LM group, this change was observed in 84.8% of subjects with @entity6 compared with 43.8% of those without @entity6 (P<0.01). Most early @entity2 , @entity5 , and @entity3 observed in this study became well demarcated after LM administration, although the incidence of @entity4 did not differ significantly between the two groups. Conclusion: LM changes the gastric mucosa into @entity1 , and this occurs more frequently in @entity2 than in pathologic lesions. LM may facilitate the demarcation of pathologic @entity4 without intestinal metaplasia.

title: @entity7 sprayed on gastric mucosa causes XXXX change.

answer: @entity1


abstract: BACKGROUND: Improvised explosive devices are a common feature of recent asymmetric conflicts and there is a persistent landmine threat to military and humanitarian personnel. Assessment of injury risk to the spine in vehicles subjected to explosions was conducted using a standardized model, the Dynamic Response Index (DRI). However, the DRI was intended for evaluating aircraft ejection seats and has not been validated in blast conditions. QUESTIONS/PURPOSES: We asked whether the injury patterns seen in blast are similar to those in aircraft ejection and therefore whether a single injury prediction model can be used for both situations. METHODS: UK military victims of mounted blast (seated in a vehicle) were identified from the Joint Theatre @entity1 Registry. Each had their initial CT scans reviewed to identify @entity2 . A literature search identified a comparison population of ejected aircrew with @entity2 . Seventy-eight blast victims were identified with 294 @entity2 . One hundred eighty-nine @entity0 who had sustained aircraft ejection were identified with 258 @entity2 . The Kruskal-Wallis test was used to compare the population injury distributions and Fisher's exact test was used to assess differences at each spinal level. RESULTS: The distribution of injuries between blast and ejection was not similar. In the cervical spine, the relative risk of injury was 11.5 times higher in blast; in the lumbar spine the relative risk was 2.9 times higher in blast. In the thoracic spine, the relative risk was identical in blast and ejection. At most individual vertebral levels including the upper thoracic spine, there was a higher risk of @entity3 , but the opposite was true between T7 and T12, where the risk was higher in aircraft ejection. CONCLUSIONS: The patterns of injury in blast and aircraft are different, suggesting that the two are mechanistically dissimilar. At most vertebral levels there is a higher relative risk of @entity2 in the blast population, but at the apex of the thoracic spine and in the lower thoracic spine, there is a higher risk in ejection victims. The differences in relative risk at different levels, and the resulting overall different injury patterns, suggest that a single model cannot be used to predict the risk of injury in ejection and blast. CLINICAL RELEVANCE: A new model needs to be developed to aid in the design of mine-protected vehicles for future conflicts.

title: XXXX in the Spine: Dynamic Response Index Is Not an Appropriate Model for Predicting Injury.

answer: @entity3


abstract: The transient kinetics under single turnover conditions of the dimeric enzyme @entity1 liver @entity0 dehydrogenase (LADH) are often biphasic with nearly equal amplitudes in the fast and slow components of the reaction. These observations have been the basis for the suggestion that this enzyme displays half of the sites reactivity or kinetic site-site interactions in its catalytic cycle [Bernhard, S.A., Dunn, M.F., Luisi, P.L., _ Shack, P. (1970) Biochemistry 9, 185]. Alternatively, the biphasic kinetics could be the result of a complex mechanistic path at a single site with no kinetic interactions between the active sites [Kvassman, J., _ Pettersson, G. (1976) Eur. J. Biochem. 62, 279; Kvassman, J., _ Pettersson, G. (1978) Eur. J. Biochem. 87, 417]. To resolve this question, we have prepared LADH in which one of the two active sites is occupied by the strongly bound, slowly exchanging ternary complex inhibitors @entity2 with @entity4 or @entity2 with @entity3 . These half-inhibited dimers show essentially the same biphasic transient kinetics as the native enzyme. These results strongly support mechanisms in which the observed kinetics are a property of each independently functioning site of the dimer. The possibility of half of the sites reactivity or kinetic site-site interaction appears to be ruled out.

title: Biphasic transient kinetics are a property of a single site in @entity1 liver XXXX dehydrogenase.

answer: @entity0


abstract: The transient kinetics under single turnover conditions of the dimeric enzyme @entity1 liver @entity0 dehydrogenase (LADH) are often biphasic with nearly equal amplitudes in the fast and slow components of the reaction. These observations have been the basis for the suggestion that this enzyme displays half of the sites reactivity or kinetic site-site interactions in its catalytic cycle [Bernhard, S.A., Dunn, M.F., Luisi, P.L., _ Shack, P. (1970) Biochemistry 9, 185]. Alternatively, the biphasic kinetics could be the result of a complex mechanistic path at a single site with no kinetic interactions between the active sites [Kvassman, J., _ Pettersson, G. (1976) Eur. J. Biochem. 62, 279; Kvassman, J., _ Pettersson, G. (1978) Eur. J. Biochem. 87, 417]. To resolve this question, we have prepared LADH in which one of the two active sites is occupied by the strongly bound, slowly exchanging ternary complex inhibitors @entity2 with @entity4 or @entity2 with @entity3 . These half-inhibited dimers show essentially the same biphasic transient kinetics as the native enzyme. These results strongly support mechanisms in which the observed kinetics are a property of each independently functioning site of the dimer. The possibility of half of the sites reactivity or kinetic site-site interaction appears to be ruled out.

title: Biphasic transient kinetics are a property of a single site in XXXX liver @entity0 dehydrogenase.

answer: @entity1


abstract: INTRODUCTION: Bouveret's Syndrome is a rare cause of @entity3 ( @entity3 ) caused by a @entity5 which has migrated into the duodenal bulb from a bilioduodenal fistula. It is an uncommon condition and only a few cases have been reported in the medical literature till to date. PRESENTATION OF CASE: We report a case of a 45 year old @entity0 who presented to us with recurrent @entity1 in the upper abdomen for the last 8 years, and that progressed to develop symptoms of @entity3 . An upper gastrointestinal endoscopy revealed duodenal ulceration with a stony hard lesion in the first part of duodenum. An contrast enhanced computed tomography (CECT) scan of the abdomen performed later confirmed the presence of @entity4 and a @entity5 in proximal jejunum. DISCUSSION: @entity2 is a case of @entity3 caused by the impaction of a @entity5 in the duodenum as a result of a @entity4 . It constitutes 1-3% of cases of @entity5 ileus which in turn complicates only 0.3-4% cases of cholelithisasis. @entity2 is managed surgically. CONCLUSION: @entity2 being an uncommon condition may pose a difficulty in diagnosis and dilemma in managing such @entity0 . An awareness is hence essential.

title: A rare presentation of XXXX ( @entity3 ) - The @entity2 .

answer: @entity3


abstract: INTRODUCTION: Bouveret's Syndrome is a rare cause of @entity3 ( @entity3 ) caused by a @entity5 which has migrated into the duodenal bulb from a bilioduodenal fistula. It is an uncommon condition and only a few cases have been reported in the medical literature till to date. PRESENTATION OF CASE: We report a case of a 45 year old @entity0 who presented to us with recurrent @entity1 in the upper abdomen for the last 8 years, and that progressed to develop symptoms of @entity3 . An upper gastrointestinal endoscopy revealed duodenal ulceration with a stony hard lesion in the first part of duodenum. An contrast enhanced computed tomography (CECT) scan of the abdomen performed later confirmed the presence of @entity4 and a @entity5 in proximal jejunum. DISCUSSION: @entity2 is a case of @entity3 caused by the impaction of a @entity5 in the duodenum as a result of a @entity4 . It constitutes 1-3% of cases of @entity5 ileus which in turn complicates only 0.3-4% cases of cholelithisasis. @entity2 is managed surgically. CONCLUSION: @entity2 being an uncommon condition may pose a difficulty in diagnosis and dilemma in managing such @entity0 . An awareness is hence essential.

title: A rare presentation of @entity3 ( XXXX ) - The @entity2 .

answer: @entity3


abstract: INTRODUCTION: Bouveret's Syndrome is a rare cause of @entity3 ( @entity3 ) caused by a @entity5 which has migrated into the duodenal bulb from a bilioduodenal fistula. It is an uncommon condition and only a few cases have been reported in the medical literature till to date. PRESENTATION OF CASE: We report a case of a 45 year old @entity0 who presented to us with recurrent @entity1 in the upper abdomen for the last 8 years, and that progressed to develop symptoms of @entity3 . An upper gastrointestinal endoscopy revealed duodenal ulceration with a stony hard lesion in the first part of duodenum. An contrast enhanced computed tomography (CECT) scan of the abdomen performed later confirmed the presence of @entity4 and a @entity5 in proximal jejunum. DISCUSSION: @entity2 is a case of @entity3 caused by the impaction of a @entity5 in the duodenum as a result of a @entity4 . It constitutes 1-3% of cases of @entity5 ileus which in turn complicates only 0.3-4% cases of cholelithisasis. @entity2 is managed surgically. CONCLUSION: @entity2 being an uncommon condition may pose a difficulty in diagnosis and dilemma in managing such @entity0 . An awareness is hence essential.

title: A rare presentation of @entity3 ( @entity3 ) - The XXXX .

answer: @entity2


abstract: INTRODUCTION: While left sided @entity5 is common in Western countries, right sided @entity5 is rare. With increasing migration from Asia, many western countries including Australia, are now seeing more right sided @entity1 , of which @entity6 is the commonest. This study aims to determine the incidence of @entity6 in @entity0 presenting with @entity7 , as well as identify the symptoms and clinical features that may aid in making a pre-operative diagnosis. METHODS: Data was collected using the Queen Elizabeth II Hospital medical records database identifying @entity0 diagnosed with @entity7 and, more specifically, those with @entity6 from January 2007 to December 2013. Only those @entity0 who had confirmed @entity6 on imaging studies or at laparoscopy on their first admission were included in this study. RESULTS: A total of 632 @entity0 with @entity7 were admitted to our institution over a seven-year period, of which 13 @entity0 had @entity6 (2.06%). Of the 13 @entity0 , twelve were of Asian background and ten were considered young ( <=50 years of age). The main complaints were right sided @entity3 (n  =  11, 84.6%) and @entity2 (n  =  5, 38.5%). Nine were diagnosed using computed tomography (n  =  9/10, 90%), three on laparoscopy and one using ultrasound (n  =  1/2, 50%). Ten @entity0 were treated successfully by conservative means. DISCUSSION: A high index of suspicion in Asian @entity0 with atypical symptoms of @entity4 , especially @entity2 , may provide the diagnosis of @entity6 .

title: Caecal XXXX : Presentation and management.

answer: @entity6


abstract: BACKGROUND: The current study is the first to examine the effectiveness and @entity1 of postoperative intensity-modulated radiotherapy (IMRT) in the treatment of @entity2 ( @entity2 ) abutting the vasculature. Specifically, we aim to assess the role of IMRT in @entity0 with @entity2 undergoing null-margin (no real resection margin) resection. METHODS: Thirty-eight @entity0 with @entity2 adherent to major blood vessels were included in this retrospective study. Null-margin resection was performed on all @entity0 ; 14 @entity0 were further treated with IMRT. The median radiation dose delivered was 56.8 Gy (range, 50-60 Gy). The primary endpoints were overall survival (OS) and disease-free survival (DFS). RESULTS: At a median follow-up of 24.6 months, the median OS and DFS of all @entity0 (n=38) were 17.7 months (95% CI, 13.2-22.2) and 9.9 months (95% CI, 2.8-17.0), respectively. Median OS was 21.8 months (95% CI, 15.5-28.1) among the 14 @entity0 in the postoperative IMRT group and 15.0 months (95% CI, 9.2-20.9) among the 24 @entity0 in the surgery-only group (P=0.049). Median DFS was 12.5 months (95% CI, 6.8-18.2) in the postoperative IMRT group and 5.5 months (95% CI, 0.7-12.3) in the surgery-only group (P=0.081). IMRT was well-tolerated. Acute @entity1 included one case of Grade 3 @entity3 ; late @entity1 included one case of asymptomatic duodenal ulcer discovered through endoscopy. CONCLUSIONS: The study results suggest that postoperative IMRT is a safe and effective treatment option following null-margin resections of @entity2 . Larger prospective and randomized trials are necessary to establish postoperative IMRT as a standard practice for the treatment of @entity2 adherent to major hepatic vessels.

title: Intensity-modulated radiotherapy following null-margin resection is associated with improved survival in the treatment of XXXX .

answer: @entity2


abstract: UNASSIGNED: As signal molecules produced within the plant, phytohormones (plant hormones) control plant growth and development through the regulation of gene expression. They play also a crucial role in the regulation of cellular activities including elongation, cell division and differentiation, organogenesis, pattern formation, reproduction and responses to abiotic and biotic stress conditions. Cytokinins, auxins, gibberellins, @entity1 and @entity0 are five classic phytohormones that had been discovered by the middle of the twentieth century, while @entity3 , @entity2 , jasmonates and salicylates are of more recently characterized @entity4 . Interaction between different phytohormone pathways is essential in coordinating tissue outgrowth in response to environmental changes. In the past decades, hormone research has focused on elucidating signal transduction pathways from hormone perception to response. Such efforts have been well paid off by recent discoveries of almost all receptors for major classes of phytohormones. While receptors and pathways for individual hormones are being illustrated, growing evidence suggests that these signaling pathways are interconnected in a complex network. In these pathways, phytohormones not only coordinate fundamental developmental cues, but also convey environmental inputs by means of synergistic or antagonistic actions referred to as signaling crosstalk. Focusing on hormone action and crosstalk, this work suggested concentrating on phytohormones signaling, particularly cytokinin crosstalk with other hormones, in various plants. Plant responses to biotic and abiotic stresses are also elucidated regarding the dramatic recent progress in understanding the cytokinin-other phytohormones crosstalk.

title: XXXX Crosstalk Research: Cytokinin And Its Crosstalk With Other Phytohormones.

answer: @entity4


abstract: UNASSIGNED: We described herein a @entity0 who presented an overlap syndrome of @entity18 ( @entity18 ) and childhood-onset @entity14 (c- @entity14 ). A 9-year-old @entity0 presented tender subcutaneous nodules on feet, arterial @entity3 , @entity13 and dysarthric speech. She was hospitalized due to @entity2 and left foot drop. Brain computer tomography showed @entity5 . Magnetic resonance angiography revealed @entity12 in the middle cerebral and internal carotid arteries. Electroneuromyography identified a mononeuropathy of left posterior tibial nerve and she fulfilled the @entity18 validated criteria. She was treated with intravenous @entity15 pulse therapy followed by @entity4 , that was progressively tapered, six months of intravenous @entity10 and after that she received @entity6 for 19 months. At the age of 14 years and 9 months, she presented @entity16 , photosensitivity, @entity1 in lower limbs and arterial @entity3 . The @entity9 was 1.7g/day. Antinuclear antibodies (ANA) were 1/1280 (homogeneous nuclear pattern) and anti-dsDNA antibodies were positive. Renal biopsy showed focal proliferative and @entity8 . Therefore, she fulfilled the American College of Rheumatology classification criteria for @entity14 and she was treated with @entity4 , @entity17 and @entity7 . In conclusion, we described herein a possible overlap syndrome of two @entity11 , where @entity18 occurred five years before the c- @entity14 diagnosis.

title: [Childhood-onset systemic polyarteritis nodosa and XXXX : an overlap syndrome?]

answer: @entity14


abstract: @entity2 ( @entity2 ) is now common in Thailand with an increase in incidence over time. Health authorities are planning to implement a nationwide @entity2 screening program using @entity4 ( @entity4 ) as a primary screening tool. This study aimed to estimate preferences and acceptance of @entity4 and colonoscopy, explore factors influencing the acceptance, and investigate reasons behind choosing and rejecting to screen before the program was implemented. @entity0 aged 50-69, visiting the primary care unit during the study period, were invited to join this study. @entity0 with a history of @entity1 or past @entity2 screening were excluded. Face-to-face interviews were conducted. Subjects were informed about @entity2 and the screening tests: @entity4 and colonoscopy. Then, they were asked for their opinions regarding the screening. The total number of subjects was 437 (86.7% response rate). Fifty-eight percent were females. The median age was 58 years. @entity4 was accepted by 74.1% of subjects compared to 55.6% for colonoscopy. The acceptance of colonoscopy was associated with perceived susceptibility to @entity2 and family history of @entity1 . No symptoms, unwilling to screen, healthy, too busy and anxious about diagnosis were reasons for refusing to screen. @entity4 was preferred for its simplicity and non-invasiveness compared with colonoscopy. Those rejecting @entity4 expressed a strong preference for colonoscopy. Subjects chose colonoscopy because of its accuracy; it was refused for the process and complications. If the screening program is implemented for the entire target population in Thailand, we estimate that 106,546 will have a positive @entity4 , between 8,618 and 12,749 identified with advanced @entity3 and between 2,645 and 3,912 identified with @entity2 in the first round of the program.

title: Preferences and acceptance of XXXX screening in Thailand.

answer: @entity2


abstract: @entity0 with @entity1 ( @entity1 ) presents with primary skeletal manifestations such as tall stature, chest wall abnormality, and @entity2 . These primary skeletal manifestations affect the growth pattern in @entity1 . Therefore, it is not appropriate to use normal growth charts to evaluate the growth status of @entity1 . We aimed to develop disease-specific growth charts for @entity1 @entity0 and to use these growth charts for understanding the growth patterns in @entity1 and managing of @entity0 with @entity1 . Anthropometric data were available from 187 males and 152 females with @entity1 through a retrospective review of medical records. Disease-specific growth charts were generated and 3, 25, 50, 75, and 97 percentiles were calculated using the LMS (refers to   ,  , and   , respectively) smoothing procedure for height and weight. Comparisons between @entity1 @entity0 and the general population were performed using a one-sample t-test. With regard to the height, the 50th percentile of @entity1 is above the normative 97th percentile in both genders. With regard to the weight, the 50 percentile of @entity1 is above the normative 75th percentile in male and between the normative 50th percentile and the 75th percentile in female. The disease-specific growth charts for Korean @entity0 with @entity1 can be useful for monitoring growth patterns, planning the timing of growth-reductive therapy, predicting adult height and recording responses to growth-reductive therapy.

title: Disease-specific Growth Charts of Marfan Syndrome XXXX in Korea.

answer: @entity0


abstract: OBJECTIVE: To evaluate the complication rate and its impact in @entity0 who have undergone upper abdominal surgery for treatment of advanced @entity2 . METHODS: @entity0 who have undergone upper abdominal surgery including diaphragm surgery, splenectomy, distal pancreatectomy, gastric resection, liver resection and biliary surgery were considered for the study. Perioperative complications were evaluated and graded according to Clavien-Dindo. RESULTS: One hundred and twenty one @entity0 were included. Two hundred and twelve surgical procedures were performed. Thirty-six @entity0 reported at least one complication, but 61.1% of these the complication was mild. Median hospital stay for @entity0 with and without complication was 7 vs. 13days respectively (p<0.001). There was a significant correlation between post-operative hospital stay and the total number of surgical procedures (R=0.445, p<0.001). At multivariate analysis, diaphragmatic resection and pancreatic resection were associated with a significant increase of postoperative hospital stay, furthermore diaphragmatic resection (p=0.004), hepatic resection (p=0.004), pancreatectomy (p=0.011) and biliary surgery (p=0.049) were independent predictors of severe (G3-G4) complication. CONCLUSIONS: Rate of complications of @entity0 submitted to upper abdominal surgery for @entity2 is acceptable. Prediction of severe complications is the goal for its optimal management. Extensive procedures should be avoided with those @entity0 in which optimal @entity1 could not be reached.

title: Predictors of postoperative morbidity after cytoreduction for advanced XXXX : Analysis and management of complications in upper abdominal surgery.

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ) is commonly associated with @entity4 ( @entity4 ), which adversely affects outcome. Surgical ablation of @entity4 during surgery for @entity5 has been shown to be effective, but the optimal lesion set remains unknown. METHODS: Between 1995 and 2010, 86 @entity0 had corrective surgery for @entity5 and concomitant maze procedure for associated @entity4 . Median age at operation was 40 years (range, 1 to 72 years), and 49 @entity0 (60%) were male. Preoperative @entity4 was paroxysmal in 43 @entity0 (50%). All @entity0 who had diagnosis of or treatment for accessory pathways and reentrant @entity3 were excluded from this analysis. RESULTS: All @entity0 underwent tricuspid valve surgery for @entity5 and concomitant maze procedure, including right-sided maze (RSM) in 62 @entity0 (72%) and biatrial maze (BAM) in 24 @entity0 (28%). Early mortality occurred in 3 @entity0 (3.5%). During median follow-up of 52 months (range, 3 months to 17 years), overall freedom from @entity4 without antiarrhythmic medications was 79% (RSM, 80% versus BAM, 76%; p  = 0.97). Although there was no difference in rhythm outcome between RSM and BAM for @entity0 with paroxysmal @entity4 (p  = 0.08), there was a trend toward higher freedom from AF without antiarrhythmic medications in @entity0 with persistent @entity4 for BAM (86%) versus RSM (71%; p  = 0.053). Overall, there were no late @entity1 , and 84% were free from sodium warfarin anticoagulation. CONCLUSIONS: Overall, surgical ablation of preoperative @entity4 is effective in @entity0 undergoing surgery for @entity5 . Although rhythm outcome of RSM and BAM did not differ in @entity0 with preoperative paroxysmal @entity4 , those with persistent or permanent @entity4 may benefit from a @entity2 set.

title: Optimal Surgical Ablation of Atrial Tachyarrhythmias During Correction of XXXX .

answer: @entity5


abstract: UNASSIGNED: Background     Mumijo (shilajit) has been well known in traditional medicine as a remedy for a number of diseases, such as @entity5 , @entity3 , @entity2 , and @entity0 . It is also widely used as an analgesic agent in folk medicine, but no scientific documentation exists concerning that effect. Objective     The current study was conducted to evaluate the ability of mumijo to reduce sensitivity to painful stimuli when compared with @entity8 and @entity10 . Methods     A total of 176 animals were randomly and equally divided into 2 groups with 88 @entity1 each-one for @entity6 test and the other for writhing test. For each test, the animals were allocated into 10 equal groups, based on the dosage of the analgesic, plus a negative control group, with 8 @entity1 in each group. Intervention     The analgesic effect of mumijo extract in doses of 0.75, 7.5, 75, and 750 mg/kg was assessed and compared witha group receiving distilled water-the negative control group, and that for groups receiving 1, 2, or 4 mg/kg of @entity8 or 10, 20, or 30 mg/kg of @entity10 -the positive control groups. Results     The results showed a significant decrease in @entity4 intensity for all @entity1 receiving doses of mumijo extract during a 1-h @entity6 test when compared with the distilled water group. For all the mumijo groups except the one receiving 750 mg/kg, the analgesic effect was significantly lower than that for the @entity8 group receiving 4 mg/kg. No significant differences existed between all mumijo and all @entity10 groups. In a writhing test, a significant inhibition of the @entity4 response induced by @entity9 also occurred in all 4 mumijo-administered groups as opposed to the group receiving distilled water. No significant differences existed between the writhing response in groups receiving 75 and 750 mg/kg of mumijo and any doses of @entity10 or @entity8 . The comparison among the different doses of mumijo in the @entity6 test did not show any significant differences, but in the writhing test, the maximum dose showed a more effective analgesic action. Conclusion     The findings indicated a significant analgesic effect for mumijo extract on @entity7 in @entity1 , occurring in a dose-independent manner.

title: Mumijo Attenuates Chemically Induced Inflammatory XXXX in @entity1 .

answer: @entity4


abstract: UNASSIGNED: Background     Mumijo (shilajit) has been well known in traditional medicine as a remedy for a number of diseases, such as @entity5 , @entity3 , @entity2 , and @entity0 . It is also widely used as an analgesic agent in folk medicine, but no scientific documentation exists concerning that effect. Objective     The current study was conducted to evaluate the ability of mumijo to reduce sensitivity to painful stimuli when compared with @entity8 and @entity10 . Methods     A total of 176 animals were randomly and equally divided into 2 groups with 88 @entity1 each-one for @entity6 test and the other for writhing test. For each test, the animals were allocated into 10 equal groups, based on the dosage of the analgesic, plus a negative control group, with 8 @entity1 in each group. Intervention     The analgesic effect of mumijo extract in doses of 0.75, 7.5, 75, and 750 mg/kg was assessed and compared witha group receiving distilled water-the negative control group, and that for groups receiving 1, 2, or 4 mg/kg of @entity8 or 10, 20, or 30 mg/kg of @entity10 -the positive control groups. Results     The results showed a significant decrease in @entity4 intensity for all @entity1 receiving doses of mumijo extract during a 1-h @entity6 test when compared with the distilled water group. For all the mumijo groups except the one receiving 750 mg/kg, the analgesic effect was significantly lower than that for the @entity8 group receiving 4 mg/kg. No significant differences existed between all mumijo and all @entity10 groups. In a writhing test, a significant inhibition of the @entity4 response induced by @entity9 also occurred in all 4 mumijo-administered groups as opposed to the group receiving distilled water. No significant differences existed between the writhing response in groups receiving 75 and 750 mg/kg of mumijo and any doses of @entity10 or @entity8 . The comparison among the different doses of mumijo in the @entity6 test did not show any significant differences, but in the writhing test, the maximum dose showed a more effective analgesic action. Conclusion     The findings indicated a significant analgesic effect for mumijo extract on @entity7 in @entity1 , occurring in a dose-independent manner.

title: Mumijo Attenuates Chemically Induced Inflammatory @entity4 in XXXX .

answer: @entity1


abstract: PURPOSE: To determine whether @entity2 reduces @entity1 scores compared to placebo in @entity0 with chronic @entity4 refractory to drug therapy. METHODS: Subjects with chronic @entity4 due to benign conditions and refractory to drug therapy were invited to participate in a randomized, double blind, superiority trial at a tertiary reference center. Subjects were randomly allocated to receive paraspinal anesthetic block with 1% @entity5 without @entity3 or placebo (control). @entity5 was injected along the spinal process of the @entity1 segment in the supra- and interspinal ligaments using a 25G X 2" needle. Placebo consisted of introduction of the needle in the same segment without injecting any substance. The main outcome measured was the @entity1 score based on a visual analog scale at T0 (baseline), T1 (within 15 min after the procedure) and T2 (one week after the procedure). Data were statistically analyzed by ANOVA and the 95% confidence interval (95%CI). RESULTS: Mean age was similar for both groups, i.e., 51.2 (paraspinal anesthetic block) and 51.8 years (control). A blind examiner measured the degree of @entity1 according to the visual analog scale from 0 (no @entity1 ) to 10 ( @entity1 imaginable). Based on the visual analog scale, the mean @entity1 scores of the paraspinal anesthetic block group at T0, T1 and T2 were 5.50 (SD=2.92; 95%CI 3.84-7.15), 2.72 (SD=2.10; 95%CI 1.53-3.90), and 4.36 (SD=2.37; 95%CI 1.89-6.82), respectively. The difference between T0 and T1 was statistically significant, with p=0.03. CONCLUSIONS: Paraspinal anesthetic block had a small effect on visual analog scale @entity1 score immediately after the injections, but no sustained benefit after one week. Further studies are needed to determine the efficacy of paraspinal anesthetic block with different @entity5 doses for the treatment of @entity6 of other causes.

title: Efficacy of paraspinal anesthetic block in @entity0 with chronic XXXX refractory to drug therapy: a randomized clinical trial.

answer: @entity4


abstract: PURPOSE: To determine whether @entity2 reduces @entity1 scores compared to placebo in @entity0 with chronic @entity4 refractory to drug therapy. METHODS: Subjects with chronic @entity4 due to benign conditions and refractory to drug therapy were invited to participate in a randomized, double blind, superiority trial at a tertiary reference center. Subjects were randomly allocated to receive paraspinal anesthetic block with 1% @entity5 without @entity3 or placebo (control). @entity5 was injected along the spinal process of the @entity1 segment in the supra- and interspinal ligaments using a 25G X 2" needle. Placebo consisted of introduction of the needle in the same segment without injecting any substance. The main outcome measured was the @entity1 score based on a visual analog scale at T0 (baseline), T1 (within 15 min after the procedure) and T2 (one week after the procedure). Data were statistically analyzed by ANOVA and the 95% confidence interval (95%CI). RESULTS: Mean age was similar for both groups, i.e., 51.2 (paraspinal anesthetic block) and 51.8 years (control). A blind examiner measured the degree of @entity1 according to the visual analog scale from 0 (no @entity1 ) to 10 ( @entity1 imaginable). Based on the visual analog scale, the mean @entity1 scores of the paraspinal anesthetic block group at T0, T1 and T2 were 5.50 (SD=2.92; 95%CI 3.84-7.15), 2.72 (SD=2.10; 95%CI 1.53-3.90), and 4.36 (SD=2.37; 95%CI 1.89-6.82), respectively. The difference between T0 and T1 was statistically significant, with p=0.03. CONCLUSIONS: Paraspinal anesthetic block had a small effect on visual analog scale @entity1 score immediately after the injections, but no sustained benefit after one week. Further studies are needed to determine the efficacy of paraspinal anesthetic block with different @entity5 doses for the treatment of @entity6 of other causes.

title: Efficacy of paraspinal anesthetic block in XXXX with chronic @entity4 refractory to drug therapy: a randomized clinical trial.

answer: @entity0


abstract: UNASSIGNED: Early detection of an @entity0 incursion will minimize the impact of outbreaks in livestock. Syndromic surveillance based on the analysis of readily available data can enhance traditional surveillance systems and allow veterinary authorities to react in a timely manner. This study was based on monitoring the number of @entity2 carcasses sent for rendering in the veterinary unit of Talavera de la Reina (Spain). The aim was to develop a system to detect deviations from expected values which would signal unexpected health events. Historical weekly collected dead @entity2 (WCDC) time series stabilized by the Box-Cox transformation and adjusted by the minimum least squares method were used to build the univariate cycling regression model based on a Fourier transformation. Three different models, according to type of production system, were built to estimate the baseline expected number of WCDC. Two types of risk signals were generated: point risk signals when the observed value was greater than the upper 95% confidence interval of the expected baseline, and cumulative risk signals, generated by a modified cumulative sum algorithm, when the cumulative sums of reported @entity1 were above the cumulative sum of expected @entity1 . Data from 2011 were used to prospectively validate the model generating seven risk signals. None of them were correlated to @entity0 events but some coincided, in time, with very high climatic temperatures recorded in the region. The harvest effect was also observed during the first week of the study year. Establishing appropriate risk signal thresholds is a limiting factor of predictive models; it needs to be adjusted based on experience gained during the use of the models. To increase the sensitivity and specificity of the predictions epidemiological interpretation of non-specific risk signals should be complemented by other sources of information. The methodology developed in this study can enhance other existing early detection surveillance systems. Syndromic surveillance based on mortality monitoring can reduce the detection time for certain disease outbreaks associated with mild mortality only detected at regional level. The methodology can be adapted to monitor other parameters routinely collected at farm level which can be influenced by communicable diseases.

title: Syndromic surveillance system based on near real-time XXXX mortality monitoring.

answer: @entity2


abstract: BACKGROUND: Risk scores for @entity1 ( @entity1 ) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have T1 mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater @entity3 . METHODS: @entity1 risk scores for 1208 subjects ( @entity0 , 50.8%) ages 55-94 years old were evaluated in the Multiethnic Study of @entity4 (MESA) at six centers. T1 times were determined at 1.5Tesla before and after @entity5 administration (0.15  mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native T1, 12 and 25  minute post- @entity5 T1, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. @entity1 risk scores were significantly different for @entity0 and @entity0 (p   <   0.001). RESULTS: 25  minute post @entity5 T1 time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native T1 (7/14 scores, 50%) and partition coefficient (7/14, 50%) in @entity0 . Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR @entity2 index. CONCLUSIONS: @entity0 with greater @entity1 risk had greater CMR indices of @entity3 . T1 times at greater delay time (25  minutes) showed better agreement with commonly used risk score indices compared to ECV and native T1 time. CLINICAL TRIAL REGISTRATION: http://www.mesa-nhlbi.org/, NCT00005487.

title: The association between cardiovascular risk and cardiovascular magnetic resonance measures of XXXX : the Multi-Ethnic Study of @entity4 (MESA).

answer: @entity2


abstract: BACKGROUND: Risk scores for @entity1 ( @entity1 ) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have T1 mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater @entity3 . METHODS: @entity1 risk scores for 1208 subjects ( @entity0 , 50.8%) ages 55-94 years old were evaluated in the Multiethnic Study of @entity4 (MESA) at six centers. T1 times were determined at 1.5Tesla before and after @entity5 administration (0.15  mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native T1, 12 and 25  minute post- @entity5 T1, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. @entity1 risk scores were significantly different for @entity0 and @entity0 (p   <   0.001). RESULTS: 25  minute post @entity5 T1 time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native T1 (7/14 scores, 50%) and partition coefficient (7/14, 50%) in @entity0 . Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR @entity2 index. CONCLUSIONS: @entity0 with greater @entity1 risk had greater CMR indices of @entity3 . T1 times at greater delay time (25  minutes) showed better agreement with commonly used risk score indices compared to ECV and native T1 time. CLINICAL TRIAL REGISTRATION: http://www.mesa-nhlbi.org/, NCT00005487.

title: The association between cardiovascular risk and cardiovascular magnetic resonance measures of @entity2 : the Multi-Ethnic Study of XXXX (MESA).

answer: @entity4


abstract: BACKGROUND: Long non-coding RNAs (lncRNAs) are emerging as molecules that significantly impact many cellular processes and have been associated with almost every @entity0 @entity1 . Compared to protein-coding genes, lncRNA genes are often associated with transposable elements, particularly with endogenous retroviral elements (ERVs). ERVs can have potentially deleterious effects on genome structure and function, so these elements are typically silenced in normal somatic tissues, albeit with varying efficiency. The aberrant regulation of ERVs associated with lncRNAs (ERV-lncRNAs), coupled with the diverse range of lncRNA functions, creates significant potential for ERV-lncRNAs to impact @entity1 biology. METHODS: We used RNA-seq analysis to identify and profile the expression of a novel lncRNA in six large cohorts, including over 7,500 samples from The @entity1 (TCGA). RESULTS: We identified the @entity1 -specific expression of a novel lncRNA that we have named Endogenous retroViral-associated @entity3 RNA or ' @entity4 ', by analyzing RNA-seq data derived from @entity2 and matched normal control tissues. Subsequent analysis of TCGA RNA-seq data revealed the striking association of @entity4 with @entity3 , which are @entity1 of glandular origin. Moderate to high levels of @entity4 were detected in 25 to 53% of colon, rectal, lung, pancreas and @entity3 (mean   =   30 to 144 FPKM), and @entity4 expression correlated with decreased @entity0 survival (Cox regression; hazard ratio   =   1.47, 95% confidence interval   =   1.06 to 2.04, P   =   0.02). In @entity1 sites of non-glandular origin, @entity4 expression was detectable at only very low levels and in less than 10% of @entity0 . For @entity4 , a MER48 ERV element provides an active promoter to drive its transcription. Genome-wide, MER48 insertions are associated with nine lncRNAs, but none of the MER48-associated lncRNAs other than @entity4 were consistently expressed in @entity3 , demonstrating the specific activation of @entity4 . The sequence and structure of the @entity4 locus is highly conserved among Old World monkeys and apes but not New World monkeys or prosimians, where the MER48 insertion is absent. Conservation of the @entity4 locus suggests a functional role for this novel lncRNA in @entity0 and our closest primate relatives. CONCLUSIONS: Our results describe the specific activation of a highly conserved ERV-lncRNA in numerous @entity1 of glandular origin, a finding with diagnostic, prognostic and therapeutic implications.

title: Activation of an endogenous retrovirus-associated long non-coding RNA in @entity0 XXXX .

answer: @entity3


abstract: BACKGROUND: Long non-coding RNAs (lncRNAs) are emerging as molecules that significantly impact many cellular processes and have been associated with almost every @entity0 @entity1 . Compared to protein-coding genes, lncRNA genes are often associated with transposable elements, particularly with endogenous retroviral elements (ERVs). ERVs can have potentially deleterious effects on genome structure and function, so these elements are typically silenced in normal somatic tissues, albeit with varying efficiency. The aberrant regulation of ERVs associated with lncRNAs (ERV-lncRNAs), coupled with the diverse range of lncRNA functions, creates significant potential for ERV-lncRNAs to impact @entity1 biology. METHODS: We used RNA-seq analysis to identify and profile the expression of a novel lncRNA in six large cohorts, including over 7,500 samples from The @entity1 (TCGA). RESULTS: We identified the @entity1 -specific expression of a novel lncRNA that we have named Endogenous retroViral-associated @entity3 RNA or ' @entity4 ', by analyzing RNA-seq data derived from @entity2 and matched normal control tissues. Subsequent analysis of TCGA RNA-seq data revealed the striking association of @entity4 with @entity3 , which are @entity1 of glandular origin. Moderate to high levels of @entity4 were detected in 25 to 53% of colon, rectal, lung, pancreas and @entity3 (mean   =   30 to 144 FPKM), and @entity4 expression correlated with decreased @entity0 survival (Cox regression; hazard ratio   =   1.47, 95% confidence interval   =   1.06 to 2.04, P   =   0.02). In @entity1 sites of non-glandular origin, @entity4 expression was detectable at only very low levels and in less than 10% of @entity0 . For @entity4 , a MER48 ERV element provides an active promoter to drive its transcription. Genome-wide, MER48 insertions are associated with nine lncRNAs, but none of the MER48-associated lncRNAs other than @entity4 were consistently expressed in @entity3 , demonstrating the specific activation of @entity4 . The sequence and structure of the @entity4 locus is highly conserved among Old World monkeys and apes but not New World monkeys or prosimians, where the MER48 insertion is absent. Conservation of the @entity4 locus suggests a functional role for this novel lncRNA in @entity0 and our closest primate relatives. CONCLUSIONS: Our results describe the specific activation of a highly conserved ERV-lncRNA in numerous @entity1 of glandular origin, a finding with diagnostic, prognostic and therapeutic implications.

title: Activation of an endogenous retrovirus-associated long non-coding RNA in XXXX @entity3 .

answer: @entity0


abstract: Purpose. To evaluate of functional and cosmetic effectiveness of lower eyelid sling technique with fascia lata graft in @entity0 with lagophthalmos due to @entity4 . Material and Method. Ten @entity0 with a mean age of 55.1    19.77 years who underwent lower eyelid sling surgery with a fascia lata graft between September 2011 and January 2014 were included in this prospective study. Preoperatively and postoperatively @entity0 were evaluated in terms of corneal epithelial defects, Schirmer's test, and @entity5 ( @entity5 ). Cosmetically, vertical eyelid aperture, margin reflex distances 1 and 2 ( @entity6 and @entity7 ) and scleral show were evaluated preoperatively and postoperatively. Results. One @entity0 had @entity4 on the right side whereas the other 9 @entity0 had @entity4 on the left side. Preoperatively, 3 @entity0 were detected with @entity3 , whereas 7 @entity0 were detected with persistent corneal epithelial defects localized in the lower half of the @entity1 . In the 3 @entity0 with preoperative @entity3 , the @entity2 recovered with corneal opacity, whereas in the 7 @entity0 with punctate epitheliopathy, postoperative corneal transparency was obtained. Discussion. Lower eyelid sling technique with fascia lata graft is an effective technique for the repositioning of the lower eyelid and preventing the corneal complications.

title: Effectiveness of the Lower Eyelid Suspension Using Fascia Lata Graft for the Treatment of Lagophthalmos due to XXXX .

answer: @entity4


abstract: UNASSIGNED: The objective of this study was to evaluate the interaction of @entity3 ( @entity3 ), including the contribution of septal spurs, with the severity of subjective symptoms, impairment of health-related quality of @entity1 in @entity0 with @entity4 ( @entity4 ). One hundred seventeen @entity0 with @entity4 were assigned to three groups with mild, moderate or severe @entity3 , according to the measured nasal septal angle, including the presence of contact septal spurs. All @entity4 @entity0 completed the visual analog scale (VAS) symptom severity score and the Sino-Nasal Outcome Test (SNOT-22) questionnaire. Symptoms scores, SNOT-22 and Lund-Mackay (LM) scores among the three @entity3 groups were compared. Related anatomy from the study group was compared with 100 control @entity0 . VAS score for postnasal discharge in @entity4 @entity0 was significantly higher in @entity0 with mild @entity3 . There was a significantly higher LM score in @entity4 @entity0 with severe @entity3 , compared to those with mild (P  =  0.001) or moderate @entity3 (P  =  0.005). @entity4 @entity0 with a contact spur demonstrated a significantly higher LM score (P  =  0.006) compared to those without a contact spur, and no differences in VAS symptom scores or HRQoL scores. There was a similar prevalence of @entity3 in @entity4 @entity0 and in the non-ENT population. Our results support the conclusion that in @entity0 with @entity4 , associated @entity3 or contact septal spur do not contribute significantly to @entity4 symptom severity or @entity2 , but may have an impact on @entity1 .

title: Relationship between XXXX , symptoms and disease severity in @entity4 .

answer: @entity3


abstract: UNASSIGNED: The objective of this study was to evaluate the interaction of @entity3 ( @entity3 ), including the contribution of septal spurs, with the severity of subjective symptoms, impairment of health-related quality of @entity1 in @entity0 with @entity4 ( @entity4 ). One hundred seventeen @entity0 with @entity4 were assigned to three groups with mild, moderate or severe @entity3 , according to the measured nasal septal angle, including the presence of contact septal spurs. All @entity4 @entity0 completed the visual analog scale (VAS) symptom severity score and the Sino-Nasal Outcome Test (SNOT-22) questionnaire. Symptoms scores, SNOT-22 and Lund-Mackay (LM) scores among the three @entity3 groups were compared. Related anatomy from the study group was compared with 100 control @entity0 . VAS score for postnasal discharge in @entity4 @entity0 was significantly higher in @entity0 with mild @entity3 . There was a significantly higher LM score in @entity4 @entity0 with severe @entity3 , compared to those with mild (P  =  0.001) or moderate @entity3 (P  =  0.005). @entity4 @entity0 with a contact spur demonstrated a significantly higher LM score (P  =  0.006) compared to those without a contact spur, and no differences in VAS symptom scores or HRQoL scores. There was a similar prevalence of @entity3 in @entity4 @entity0 and in the non-ENT population. Our results support the conclusion that in @entity0 with @entity4 , associated @entity3 or contact septal spur do not contribute significantly to @entity4 symptom severity or @entity2 , but may have an impact on @entity1 .

title: Relationship between @entity3 , symptoms and disease severity in XXXX .

answer: @entity4


abstract: BACKGROUND: @entity5 ( @entity5 ) is not only a devastating disease, but also the most expensive @entity4 managed in the US. @entity3 ( @entity3 ) are common in neonates with @entity5 . We examined the effects of @entity3 on in-hospital mortality, length of stay, and costs for late preterm and term @entity0 with @entity5 undergoing stage 1 palliation, at both individual @entity0 and hospital levels. METHODS: We conducted a retrospective study of @entity0 35 weeks or greater gestation with @entity5 , admitted to our institution January 1, 2003 to January 1, 2013. @entity0 with other @entity2 , major comorbid conditions, or perinatal infections were excluded. Univariable and multivariable analyses were performed. To estimate the effects of reduced NBI incidence on resource utilization, predictive models were used. RESULTS: One hundred forty-three @entity0 met inclusion criteria. In-hospital mortality was 9.1% (n  = 13). @entity1 was observed in 12.6% (n  = 18). Median length of stay was 23 days for survivors (IQR, 17 to 40; range, 9 to 132). Median costs were  83,000 for survivors, in 2013 dollars (IQR,  62,000 to  123,000; range,  17,000 to  517,000). @entity3 were not associated with changes in mortality. In multivariable analyses, at a @entity0 level @entity3 were associated with a 74% increase in length of stay (95% confidence interval [CI], 31% to 132%, p < 0.001) and a 65% increase in costs (95% CI, 28% to 114%, p < 0.001). On a hospital level, in this cohort a 50% reduction in the incidence of @entity3 would be expected to yield a 4.3% decrease in average length of stay and a 3.8% decrease in average in- @entity0 costs. CONCLUSIONS: @entity3 in neonates with @entity5 are associated with large increases in lengths of stay and costs on a @entity0 level, but not a hospital level. For hospitals without particularly high incidences, studies are needed to identify additional targets for quality improvement.

title: Neonatal XXXX : Effects of Bloodstream Infections on Outcomes and Costs.

answer: @entity5


abstract: OBJECTIVE: The best practice tariff for hip and knee replacement in the English @entity1 ( @entity1 ) rewards providers based on improvements in @entity0 -reported outcome measures (PROMs) collected before and after surgery. Providers only receive a bonus if at least 50% of their @entity0 complete the preoperative questionnaire. We determined how many providers failed to meet this threshold prior to the policy introduction and assessed longitudinal stability of participation rates. DESIGN: Retrospective observational study using data from Hospital Episode Statistics and the national @entity2 programme from April 2009 to March 2012. We calculated participation rates based on either (a) all @entity2 records or (b) only those that could be linked to inpatient records; constructed confidence intervals around rates to account for sampling variation; applied precision weighting to allow for volume; and applied risk adjustment. SETTING: @entity1 hospitals and private providers in England. @entity0 : @entity1 @entity0 undergoing elective unilateral hip and knee replacement surgery. MAIN OUTCOME MEASURES: Number of providers with participation rates statistically significantly below 50%. RESULTS: Crude rates identified many providers that failed to achieve the 50% threshold but there were substantially fewer after adjusting for uncertainty and precision. While important, risk adjustment required restricting the analysis to linked data. Year-on-year correlation between provider participation rates was moderate. CONCLUSIONS: Participation rates have improved over time and only a small number of providers now fall below the threshold, but administering preoperative questionnaires remains problematic in some providers. We recommend that participation rates are based on linked data and take into account sampling variation.

title: Should English healthcare providers be penalised for failing to collect XXXX -reported outcome measures? A retrospective analysis.

answer: @entity0


abstract: BACKGROUND: The incidence of @entity4 among dialysis @entity0 is high, but end @entity2 was an exclusion criterion in the trials that demonstrated the benefit of @entity3 ( @entity3 ) for @entity4 prevention. METHODS: Dialysis @entity0 alive on January 2010 or starting dialysis between January 2010 and January 2013 were enrolled and retrospectively evaluated. @entity0 were divided into three groups: No-Indication, Indication-With @entity3 and Indication-Without @entity3 . Cox and Fine and Gray regression models were used to estimate the total and cause-specific (sudden or non-sudden) mortality hazard ratio (HR, HRcpRisk), respectively. Survival was defined as the time from start of dialysis to the time of @entity1 . RESULTS: 154/2072 @entity0 (7.4%) had indication for @entity3 implantation and 52 (33.8%) of them received the device; 688 (33.2%) deaths were recorded. Mortality was different among groups [Indication-With @entity3 vs No-Indication: HR 1.59 (95% CI 1.06-2.38) and Indication-Without @entity3 vs No-Indication: HR 2.67 (95% CI 2.09-3.39, p<0.001)]. 84/688 (12.2%) were @entity4 . The cumulative incidence of @entity4 was higher in @entity0 with @entity3 indication [Indication-With @entity3 vs No-Indication HRcpRisk 3.21 (95% CI 1.38-7.40) and Indication-Without @entity3 vs No-Indication: HRcpRisk 4.19 (95% CI 2.38-7.39), p<0.001], but also No-Indication @entity0 showed a high rate of @entity4 [8.5% (95% CI.6.5-10.9) at 8years of follow-up]. CONCLUSIONS: Dialysis @entity0 with @entity3 indication had a worse survival than No-Indication subjects and the prognosis was particularly poor for the Indication-Without @entity3 group. @entity4 incidence was much higher than in the general population, even among No-Indication subjects.

title: Mortality, XXXX and indication for cardioverter defibrillator implantation in a dialysis population.

answer: @entity4


abstract: BACKGROUND: Observational studies suggest index clinical manifestation of @entity4 ( @entity4 ) predicts recurrence type. Data regarding the association between index manifestation and recurrence rates are conflicting. OBJECTIVES: To perform a meta-analysis of @entity1 ( @entity1 ) to determine the type and frequency of recurrent @entity4 (rVTE) in @entity0 after an index @entity2 ( @entity2 ) or @entity3 ( @entity3 ). @entity0 /METHODS: We searched bibliographic databases for @entity1 of acute (early) treatment of rVTE in @entity0 with an index @entity2 or @entity3 (  @entity2 ), enrolling >=   50 subjects anticoagulated >=   3-months and reporting types of rVTE. We pooled (random-effects) the proportion of rVTEs that were DVTs, PEs, and fatal PEs, the proportion of recurrent PEs that were fatal, and absolute rVTE rates. RESULTS: In nine @entity1 (N  =  13  640; 413 rVTEs) evaluating @entity0 with an index @entity3 ; 66% (95% CI, 60-72%) of rVTEs were @entity3 and 27% (95% CI, 22-33%) were fatal @entity3 . Among 25 @entity1 (N  =  17  340; 692 rVTEs) evaluating @entity0 with an index @entity2 , 36% (95% CI, 29-44%) experienced a recurrent @entity3 and 10% (95% CI, 7-13%) a fatal @entity3 . Recurrent PEs following an index @entity3 had a higher fatality rate than after an index @entity2 (41%; 95% CI, 33-48% vs. 25%; 95% CI, 18-33%; P  =  0.007). The rVTE rate was higher following an index @entity2 compared with a @entity3 (2.6%; 95% CI, 1.6-3.8% vs. 4.9%; 95% CI, 4.0-6.0%; P  =  0.002). CONCLUSIONS: Our meta-analysis suggests most rVTEs will be the same type as the index event. While index DVTs are associated with a higher rVTE rate than index PEs; recurrent PEs are associated with high fatality.

title: Index clinical manifestation of XXXX predicts early recurrence type and frequency: a meta-analysis of @entity1 .

answer: @entity4


abstract: BACKGROUND: Observational studies suggest index clinical manifestation of @entity4 ( @entity4 ) predicts recurrence type. Data regarding the association between index manifestation and recurrence rates are conflicting. OBJECTIVES: To perform a meta-analysis of @entity1 ( @entity1 ) to determine the type and frequency of recurrent @entity4 (rVTE) in @entity0 after an index @entity2 ( @entity2 ) or @entity3 ( @entity3 ). @entity0 /METHODS: We searched bibliographic databases for @entity1 of acute (early) treatment of rVTE in @entity0 with an index @entity2 or @entity3 (  @entity2 ), enrolling >=   50 subjects anticoagulated >=   3-months and reporting types of rVTE. We pooled (random-effects) the proportion of rVTEs that were DVTs, PEs, and fatal PEs, the proportion of recurrent PEs that were fatal, and absolute rVTE rates. RESULTS: In nine @entity1 (N  =  13  640; 413 rVTEs) evaluating @entity0 with an index @entity3 ; 66% (95% CI, 60-72%) of rVTEs were @entity3 and 27% (95% CI, 22-33%) were fatal @entity3 . Among 25 @entity1 (N  =  17  340; 692 rVTEs) evaluating @entity0 with an index @entity2 , 36% (95% CI, 29-44%) experienced a recurrent @entity3 and 10% (95% CI, 7-13%) a fatal @entity3 . Recurrent PEs following an index @entity3 had a higher fatality rate than after an index @entity2 (41%; 95% CI, 33-48% vs. 25%; 95% CI, 18-33%; P  =  0.007). The rVTE rate was higher following an index @entity2 compared with a @entity3 (2.6%; 95% CI, 1.6-3.8% vs. 4.9%; 95% CI, 4.0-6.0%; P  =  0.002). CONCLUSIONS: Our meta-analysis suggests most rVTEs will be the same type as the index event. While index DVTs are associated with a higher rVTE rate than index PEs; recurrent PEs are associated with high fatality.

title: Index clinical manifestation of @entity4 predicts early recurrence type and frequency: a meta-analysis of XXXX .

answer: @entity1


abstract: BACKGROUND AND AIMS: Both adalimumab [ADA] and infliximab [IFX] seem to be effective in the prevention of early postoperative endoscopic recurrence [EPER] after ileocaecal resection in @entity2 [ @entity2 ] @entity0 . There is lack of data with direct comparison between the two agents in the postoperative scenario. The aim of this study was to compare the rates of EPER in @entity0 treated with ADA and IFX after ileocaecal resection for @entity2 . METHODS: This was a multicentre retrospective analysis of EPER rates in @entity2 @entity0 after ileocaecal resections, from seven referral centres in three countries. Endoscopic recurrence was defined as Rutgeerts' score >=  i2. The @entity0 were allocated according to treatment to two groups: ADA or IFX. The EPER rates were compared between the two treatment groups. RESULTS: Among the 168 @entity0 included in the database, 96 received anti- @entity1 @entity3 factor [TNF] agents after resection [37 in the ADA and 59 in the IFX groups] and were included in this comparative study. The groups were comparable in all baseline characteristics, mainly age, gender, previous resections, perianal @entity2 , and mono or combination therapy. EPER was identified in 9/37 [24.32%] in the ADA group vs 16/59 [27.12%] in the IFX group [p = 0.815]. CONCLUSIONS: In this retrospective direct comparison between ADA and IFX therapy after ileocaecal resection, there was no significant difference between the two anti-TNF agents in terms of EPER rates. However, prospective randomised studies are needed to confirm these data and better define the role of each agent in the prevention of EPER.

title: Direct retrospective comparison of adalimumab and infliximab in preventing early postoperative endoscopic recurrence after ileocaecal resection for XXXX : results from the MULTIPER database.

answer: @entity2


abstract: From 1977 to 1980, 21 second toes were transferred with microvascular anastomoses for @entity1 in 17 @entity0 . There have been no vascular failures. Four thumbs were reconstructed with very good functional and cosmetic results. Active motion of the transplanted toe is limited, and the functional results depend on the mobility and musculature of the metacarpal remnant. Growth has been continuous and at least equal to the other toe. Cosmetic results have been very good. It is essential to distinguish between @entity0 showing @entity3 and those presenting @entity2 . In the latter case, all structures are close to normal and the results are therefore better. Operative indications must be carefully appraised. If surgical intervention is decided upon, the ideal age is about 18 months, at which time the best integration of the toe is observed.

title: Toe transfers for XXXX .

answer: @entity1


abstract: UNASSIGNED: Over-expression of de novo lipogenesis (DNL) pathway genes is associated with the prognosis of various types of @entity1 . However, effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and @entity2 ( @entity2 ) @entity0 after surgery are still unknown. A total of 492 primary @entity2 @entity0 treated with surgery were included in this study. Nine SNPs in 3 genes ( @entity5 , @entity4 and @entity6 ) of DNL pathway were genotyped. Multivariate Cox proportional hazard regression model and Kaplan-Meier curve were used to analyze the association of SNPs with clinical outcomes. Two SNPs in @entity5 gene were significantly associated with overall survival of @entity2 @entity0 . @entity0 carrying homozygous variant genotype (VV) in @entity7 had significantly increased risk of @entity3 , while @entity0 carrying VV genotype in @entity8 had significant decreased risk of @entity3 , when compared with those carrying homozygous wild-type or heterozygous genotypes. Moreover, @entity0 carrying VV genotype in @entity8 had decreased recurrence risk, while @entity0 carrying variant genotype in @entity9 of @entity4 gene had increased recurrence risk. Further cumulative effect analysis showed significant dose-dependent effects of unfavorable SNPs on both @entity3 and recurrence. SNPs in DNL genes may serve as independent prognostic markers for @entity2 @entity0 after surgery.

title: Genetic variants in de novo lipogenic pathway genes predict the prognosis of surgically-treated XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity2 represent the main cause of @entity4 and invalidity all over the world. @entity0 surviving a severe @entity2 often present long-term disabilities, @entity1 , cognitive, @entity3 . @entity5 are directly caused by the traumatic agent, and indirectly caused by the action of cells involved in the restorative process. The main cells involved in the restorative process are microglias and astrocytes. By using an experimental model, we investigated the reaction of these cells in the first week after a severe @entity5 , followed by @entity2 . Of the two cell types, the most rapid and intense reaction was held by the macroglias, also known as resident macrophages of the central nervous system. Alongside the activation of local microglias, in the restorative process there were also involved blood monocytes that turned into macrophages. 24 hours after the injury, the number of macrophage cells  mm   at brain wound level increased 2-4 times, after three days - 10-12 times, and after seven days - over 20 times. The astrocyte reaction was slower, their activation being signaled no sooner than three days from injury, when their number in the perilesional brain parenchyma increased approximately two times, while after seven days - approximately 4-5 times. Both astrocytes and macrophages (microglias), besides their beneficial effects in restoring traumatic @entity5 , may have unfavorable effects upon the nervous cells in the immediate proximity of the injury. Destruction of vascular network by the traumatic agent, and the extremely slow restore of vascularization, partially explain brain neurons @entity4 on extend areas.

title: Study of restorative processes in @entity2 in the first seven days after XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity2 represent the main cause of @entity4 and invalidity all over the world. @entity0 surviving a severe @entity2 often present long-term disabilities, @entity1 , cognitive, @entity3 . @entity5 are directly caused by the traumatic agent, and indirectly caused by the action of cells involved in the restorative process. The main cells involved in the restorative process are microglias and astrocytes. By using an experimental model, we investigated the reaction of these cells in the first week after a severe @entity5 , followed by @entity2 . Of the two cell types, the most rapid and intense reaction was held by the macroglias, also known as resident macrophages of the central nervous system. Alongside the activation of local microglias, in the restorative process there were also involved blood monocytes that turned into macrophages. 24 hours after the injury, the number of macrophage cells  mm   at brain wound level increased 2-4 times, after three days - 10-12 times, and after seven days - over 20 times. The astrocyte reaction was slower, their activation being signaled no sooner than three days from injury, when their number in the perilesional brain parenchyma increased approximately two times, while after seven days - approximately 4-5 times. Both astrocytes and macrophages (microglias), besides their beneficial effects in restoring traumatic @entity5 , may have unfavorable effects upon the nervous cells in the immediate proximity of the injury. Destruction of vascular network by the traumatic agent, and the extremely slow restore of vascularization, partially explain brain neurons @entity4 on extend areas.

title: Study of restorative processes in XXXX in the first seven days after @entity2 .

answer: @entity2


abstract: AIMS: Cardiac progenitor cells (CPCs) have been isolated from adult and developing hearts using an anti-mouse @entity2 antibody. However, the absence of a @entity0 @entity2 homologue has hampered the clinical application of the CPCs. Therefore, we generated novel monoclonal antibodies (mAbs) specifically raised against surface markers expressed by resident @entity0 CPCs. Here, we explored the suitability of one of these mAbs, mAb C19, for the identification, isolation and characterization of CPCs from fetal heart tissue and differentiating cultures of @entity0 embryonic stem cells (hESCs). METHODS _ RESULTS: Using whole-cell immunization, mAbs were raised against @entity2 + CPCs and screened for reactivity to various CPC lines by flow cytometry. mAb C19 was found to be specific for @entity2 + CPCs, with high cell surface binding capabilities. mAb C19 stained small stem-like cells in cardiac tissue sections. Moreover, during differentiation of hESCs towards cardiomyocytes, a transient population of cells with mAb C19 reactivity was identified and isolated using magnetic-activated cell sorting. Their cell fate was tracked and found to improve cardiomyocyte purity from hESC-derived cultures. mAb C19+ CPCs, from both hESC differentiation and fetal heart tissues, were maintained and expanded in culture, while retaining their CPC-like characteristics and their ability to further differentiate into cardiomyocytes by stimulation with @entity1 . Finally, gene expression profiling of these mAb C19+ CPCs suggested a highly angiogenic nature, which was further validated by cell-based angiogenesis assays. CONCLUSION: mAb C19 is a new surface marker for the isolation of multipotent CPCs from both @entity0 heart tissues and differentiating hESCs.

title: mAb C19 targets a novel surface marker for the isolation of XXXX cardiac progenitor cells from @entity0 heart tissue and differentiated hESCs.

answer: @entity0


abstract: AIMS: Cardiac progenitor cells (CPCs) have been isolated from adult and developing hearts using an anti-mouse @entity2 antibody. However, the absence of a @entity0 @entity2 homologue has hampered the clinical application of the CPCs. Therefore, we generated novel monoclonal antibodies (mAbs) specifically raised against surface markers expressed by resident @entity0 CPCs. Here, we explored the suitability of one of these mAbs, mAb C19, for the identification, isolation and characterization of CPCs from fetal heart tissue and differentiating cultures of @entity0 embryonic stem cells (hESCs). METHODS _ RESULTS: Using whole-cell immunization, mAbs were raised against @entity2 + CPCs and screened for reactivity to various CPC lines by flow cytometry. mAb C19 was found to be specific for @entity2 + CPCs, with high cell surface binding capabilities. mAb C19 stained small stem-like cells in cardiac tissue sections. Moreover, during differentiation of hESCs towards cardiomyocytes, a transient population of cells with mAb C19 reactivity was identified and isolated using magnetic-activated cell sorting. Their cell fate was tracked and found to improve cardiomyocyte purity from hESC-derived cultures. mAb C19+ CPCs, from both hESC differentiation and fetal heart tissues, were maintained and expanded in culture, while retaining their CPC-like characteristics and their ability to further differentiate into cardiomyocytes by stimulation with @entity1 . Finally, gene expression profiling of these mAb C19+ CPCs suggested a highly angiogenic nature, which was further validated by cell-based angiogenesis assays. CONCLUSION: mAb C19 is a new surface marker for the isolation of multipotent CPCs from both @entity0 heart tissues and differentiating hESCs.

title: mAb C19 targets a novel surface marker for the isolation of @entity0 cardiac progenitor cells from XXXX heart tissue and differentiated hESCs.

answer: @entity0


abstract: OBJECTIVE: Because noticeable changes were made to the 7th American Joint Committee on Cancer (AJCC) @entity2 -node- @entity1 (TNM) staging for @entity3 ( @entity3 ), we validated the prognostic impact of @entity2 staging after macroscopic curative resection of @entity3 . METHODS: A cohort of 659 @entity3 @entity0 who underwent R0 (n   =   539) or R1 (n   =   120) resection were selected with exclusion of R2 resection (n   =   111). Study @entity0 were followed up for >= 24  months or until death with no @entity0 lost during survival analysis. RESULTS: Anatomical resection was performed in 599 (90.9  %) and concurrent bile duct resection was conducted in 97 (14.7  %). Median survival periods following R0, R1, and R2 resections were 28, 12, and 3  months, respectively (p   =   0.000). In the R0 resection group, the 1-, 3-, 5-, and 10-year @entity2 recurrence rates were 36.4  %, 57.9  %, 64.7  %, and 65.0  %, respectively, and the 1-, 3-, 5-, and 10-year @entity0 survival rates were 73.1  %, 44.2  %, 33.0  %, and 23.1  %, respectively. Independent risk factors for @entity2 recurrence and @entity0 survival were @entity2 growth type, @entity2 size   >   5  cm, perineural invasion, and lymph node @entity1 . According to the 7th AJCC staging system, the prognostic contrast was marginal in stage T2-4 @entity2 without lymph node @entity1 (p   >   0.8). With our redefined staging system with @entity2 growth types and risk factors including @entity2 number and @entity1 , clear prognostic contrast was achieved among T1-3 stages (p   =   0.000). CONCLUSION: Growth type of @entity3 seems to be essential for determining @entity2 stage. Although the stratification of the 7th AJCC @entity3 staging system seems reasonably established, refinements and further validation could improve prognostic predictability.

title: Prognostic Impact of Tumor Growth Type on 7th AJCC Staging System for XXXX : a Single-Center Experience of 659 Cases.

answer: @entity3


abstract: AIMS: Given the paucity of prospective data on the treatment of incontinent @entity0 with prior synthetic mid-urethral sling (MUS), we sought to report our prospective experience with autologous fascia pubovaginal sling placement (AF-PVS) after prior synthetic mid-urethral sling (MUS). METHODS: An IRB-approved, multi-institutional, prospective cohort of @entity0 from 2010 to 2013 undergoing AF-PVS for @entity1 was evaluated and stratified for the presence of a prior MUS. Pre-operative characteristics and validated quality of life questionnaires (IIQ-7 and UDI-6) were compared to post-operative pad usage, scores on the IIQ-7 and UDI-6, complications, and visual analog scale assessment of improvement. RESULTS: 288 @entity0 met inclusion criteria, 59 (20.4%) of whom had undergone a prior MUS before AF-PVS placement. Of these 59 @entity0 , 20 (33.9%) had a prior vaginal extrusion and 5 (8.5%) had suffered from obstruction requiring sling lysis or excision. With a median of 14 months follow-up, prior MUS placement was not associated with a significant difference in objective (55.9% vs. 62.4%, P   =   0.37) or subjective cure (66.1% vs. 69.0%, P   =   0.75) when compared to @entity0 undergoing placement of an initial AF-PVS. @entity0 undergoing AF-PVS after prior MUS did have a significantly higher rate of urinary retention requiring intermittent catheterization (8.5% vs. 3.1%, P   <   0.001) and re-operation (13.6% vs. 3.5%, P   =   0.01) for persistent @entity1 . CONCLUSIONS: Despite higher rates of retention and need for repeat operation, AF-PVS after failed MUS is an acceptable treatment option with no difference in success as compared to @entity0 undergoing initial AF-PVS placement. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Autologous fascia pubovaginal slings after prior synthetic anti- XXXX procedures for recurrent @entity1 : A multi-institutional prospective comparative analysis to de novo autologous slings assessing objective and subjective cure.

answer: @entity1


abstract: AIMS: Given the paucity of prospective data on the treatment of incontinent @entity0 with prior synthetic mid-urethral sling (MUS), we sought to report our prospective experience with autologous fascia pubovaginal sling placement (AF-PVS) after prior synthetic mid-urethral sling (MUS). METHODS: An IRB-approved, multi-institutional, prospective cohort of @entity0 from 2010 to 2013 undergoing AF-PVS for @entity1 was evaluated and stratified for the presence of a prior MUS. Pre-operative characteristics and validated quality of life questionnaires (IIQ-7 and UDI-6) were compared to post-operative pad usage, scores on the IIQ-7 and UDI-6, complications, and visual analog scale assessment of improvement. RESULTS: 288 @entity0 met inclusion criteria, 59 (20.4%) of whom had undergone a prior MUS before AF-PVS placement. Of these 59 @entity0 , 20 (33.9%) had a prior vaginal extrusion and 5 (8.5%) had suffered from obstruction requiring sling lysis or excision. With a median of 14 months follow-up, prior MUS placement was not associated with a significant difference in objective (55.9% vs. 62.4%, P   =   0.37) or subjective cure (66.1% vs. 69.0%, P   =   0.75) when compared to @entity0 undergoing placement of an initial AF-PVS. @entity0 undergoing AF-PVS after prior MUS did have a significantly higher rate of urinary retention requiring intermittent catheterization (8.5% vs. 3.1%, P   <   0.001) and re-operation (13.6% vs. 3.5%, P   =   0.01) for persistent @entity1 . CONCLUSIONS: Despite higher rates of retention and need for repeat operation, AF-PVS after failed MUS is an acceptable treatment option with no difference in success as compared to @entity0 undergoing initial AF-PVS placement. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Autologous fascia pubovaginal slings after prior synthetic anti- @entity1 procedures for recurrent XXXX : A multi-institutional prospective comparative analysis to de novo autologous slings assessing objective and subjective cure.

answer: @entity1


abstract: BACKGROUND: We present a case of a 51-year-old male @entity0 with @entity2 (PVNS) of the left @entity1 (TMJ) that initially presented as a slow-growing left facial mass. Upon further workup, a contrast-enhanced CT scan demonstrated an expansile soft tissue mass in the left TMJ. METHODS: The lesion was diagnosed through fine-needle aspiration biopsy. The @entity0 was treated with resection of the TMJ, temporal bone, and root of the zygoma. A temporalis muscle and temporoparietal fascia flap was used for reconstruction to fill the defect and provide contour. RESULTS: Postoperatively, the @entity0 has been tumor free with excellent cosmesis. Our case demonstrates a very successful outcome. CONCLUSION: Previous literature has also reported that complete excision is an ideal procedure for PVNS of TMJ, but temporalis rotational flap use has been rare. This case and previously reported cases in the literature are also reviewed.    2015 Wiley Periodicals, Inc. Head Neck, 2015.

title: @entity2 of the XXXX : Case report and review of the literature.

answer: @entity1