abstract: Clustering and interrelationships of common and easily identifiable risk factors in 951 @entity0 (ages 6-19) from the Cincinnati Lipid Research Clinic's Princeton School of District Study were assessed. Several patterns of partial correlation coeffieients appeared after multiple regression analysis with adjustment for age, sex, Quetelet index, and race. Systolic blood pressure (SBP) was positively correlated with plasma @entity1 and @entity3 , and with saturated fat intake. Plasma high density lipoprotein @entity1 (C-HDL) was positively associated with occupation of the head of the household and inversely associated with cigarette smoking and @entity4 intake. Using multiple regression equations, from 29-41% of the variance for SBP and diastolic blood pressure (DBP) could be explained by the measured variables, with age, skinfold thickness, Quetelet, occupation, and education of the head of the household recurrently appearing in the regression equatons. Low density lipoprotein @entity1 (C-HDL) was the variable for which the lowest amount of variance could be explained in the four race-sex groups. Discriminant function analysis allowed an assessment of interrelationships of C-LDL-C-HDL aggregate groups to other risk factor mean residuals. The variables which contributed significantly to the discrimination between lipoprotein groups were Quetelet index, skinfold thickness, and DBP. @entity0 in the highest C-LHL-lowest C-HDL quintile group had by far the highest residual Quetelet index and skinfold thickness, along with above average SBP, while those in The lowest C-LDL-highest C-HDL quintile group had the lowest residual Quetelet index, skinfold thickness, and SBP. Common risk and anti-risk factors for @entity2 ( @entity2 ) in @entity0 cluster, allowing identification of groups of @entity0 putatively at relatively high and low @entity2 risk as adults.

title: Clustering and interrelationships of XXXX risk factors in schoolchildren, ages 6-19.

answer: @entity2


abstract: BACKGROUND: This study aims to examine the public's attitudes and predictors of social distance towards @entity0 afflicted by @entity3 ( @entity4 [BN]) under specific consideration of the respondents' sex. @entity3 are still often seen as a @entity0 's health issue, and those afflicted remain stigmatized in Western societies. The concept of social distance is a frequently used indicator in awareness campaigns. Sex-specific results could add important information to destigmatization programs. METHODS: Data originate from a German telephone survey which was conducted in 2011. Vignettes with signs and symptoms either suggestive of @entity4 or BN were presented to the respondents randomly, who subsequently answered questions regarding beliefs about causes, contact to @entity0 afflicted as well as desire for social distance. Stratified multiple linear regression analyses according to disorder under study were performed to examine associations between different predictors and desire for social distance. RESULTS: There were significant sex differences in desire for social distance, causal attributions, and emotional reactions towards @entity0 with @entity3 . E.g., with respect to @entity4 , @entity0 exhibited a significantly greater desire for social distance than @entity0 (p<.001), and more frequently believed that @entity4 could be caused by @entity2 during childhood. Regarding predictors of social distance, there was a significant positive association between age and desire for social distance equally among @entity0 and @entity0 . However, distinct sex differences came into effect concerning other predictors depending on the @entity3 under study. In BN, attribution of @entity1 emerged as significant predictor of social distance among @entity0 . This is not true for @entity0 , where the attribution of weak will significantly predicted the desire for social distance. CONCLUSION: Sex-dependent differences in attitudes and predictors of social distance towards females afflicted should be met with tailored measures in anti-stigma campaigns, addressing @entity0 and @entity0 on different levels.

title: Sex differences in attitudes towards females with XXXX .

answer: @entity3


abstract: STUDY DESIGN: The risk factors for cement leakage were retrospectively reviewed in 192 @entity0 who underwent percutaneous vertebral augmentation (PVA). OBJECTIVE: To discuss the factors related to the cement leakage in PVA procedure for the treatment of @entity4 . SUMMARY OF BACKGROUND DATA: PVA is widely applied for the treatment of @entity3 . Cement leakage is a major complication of this procedure. The risk factors for cement leakage were controversial. MATERIALS AND METHODS: A retrospective review of 192 @entity0 who underwent PVA was conducted. The following data were recorded: age, sex, bone density, number of fractured vertebrae before surgery, number of treated vertebrae, severity of the treated vertebrae, operative approach, volume of injected bone cement, preoperative vertebral compression ratio, preoperative @entity2 , intraosseous clefts, preoperative @entity1 , and ratio and type of cement leakage. To study the correlation between each factor and cement leakage ratio, bivariate regression analysis was employed to perform univariate analysis, whereas multivariate linear regression analysis was employed to perform multivariate analysis. RESULTS: The study included 192 @entity0 (282 treated vertebrae), and cement leakage occurred in 100 vertebrae (35.46%). The vertebrae with preoperative cortical bone defects generally exhibited higher cement leakage ratio, and the leakage is typically type C. Vertebrae with intact cortical bones before the procedure tend to experience type S leakage. Univariate analysis showed that @entity0 age, bone density, number of fractured vertebrae before surgery, and vertebral cortical bone were associated with cement leakage ratio (P<0.05). Multivariate analysis showed that the main factors influencing bone cement leakage are bone density and @entity1 , with standardized partial regression coefficients of -0.085 and 0.144, respectively. CONCLUSION: High bone density and @entity1 are independent risk factors associated with bone cement leakage.

title: Cement Leakage in Percutaneous Vertebral Augmentation for XXXX : Analysis of Risk Factors.

answer: @entity4


abstract: OBJECTIVE: To provide prevalence estimates for @entity2 ( @entity2 ) and @entity4 ( @entity4 ) in those subjects with @entity3 using 2009-2010 National Health and Nutrition Examination Survey (NHANES) data. METHODS: In the NHANES 2009-2010 sample set, 6,684 @entity0 ages 20-69 years were screened for participation, and 5,103 answered questions regarding onset of back @entity1 , location of @entity1 , and functional limitations. Data set assembly and statistical analysis were performed using SASTM and SUDAAN software. SEs were estimated by Taylor series linearization. The equality of the prevalence estimates for selected variables was tested (univariately) at an alpha level of 0.05 using 2-sided Student's t-test with appropriate degrees of freedom. RESULTS: A total of 148 @entity0 had self-reported medically diagnosed @entity3 . The @entity3 group versus the nonpsoriasis group had a significantly higher prevalence of @entity1 using the 3-month duration criterion (31.1% versus 18.9%; P   =   0.04) and alternating buttock @entity1 (7.2% versus 2.4%; P   =   0.03) and more frequently met @entity2 criteria from Berlin criteria 7b and 8a (P   =   0.04 and 0.02, respectively). The prevalence of @entity4 was significantly higher in the @entity3 group versus the nonpsoriasis group when using Amor or @entity4 Study Group criteria (14.3% versus 1.5%; P   <   0.001). Sudden onset of @entity1 was significantly higher in the @entity3 group (23.3% versus 13.0%; P   =   0.01). CONCLUSION: There is a higher prevalence of lower @entity1 , @entity2 , @entity4 , and alternating buttock @entity1 associated with a prior diagnosis of @entity3 . These data may influence the way @entity3 @entity0 are approached in primary care and specialty clinics.

title: Prevalence of Chronic Axial @entity1 , and XXXX in Diagnosed Psoriasis.

answer: @entity4


abstract: OBJECTIVE: To provide prevalence estimates for @entity2 ( @entity2 ) and @entity4 ( @entity4 ) in those subjects with @entity3 using 2009-2010 National Health and Nutrition Examination Survey (NHANES) data. METHODS: In the NHANES 2009-2010 sample set, 6,684 @entity0 ages 20-69 years were screened for participation, and 5,103 answered questions regarding onset of back @entity1 , location of @entity1 , and functional limitations. Data set assembly and statistical analysis were performed using SASTM and SUDAAN software. SEs were estimated by Taylor series linearization. The equality of the prevalence estimates for selected variables was tested (univariately) at an alpha level of 0.05 using 2-sided Student's t-test with appropriate degrees of freedom. RESULTS: A total of 148 @entity0 had self-reported medically diagnosed @entity3 . The @entity3 group versus the nonpsoriasis group had a significantly higher prevalence of @entity1 using the 3-month duration criterion (31.1% versus 18.9%; P   =   0.04) and alternating buttock @entity1 (7.2% versus 2.4%; P   =   0.03) and more frequently met @entity2 criteria from Berlin criteria 7b and 8a (P   =   0.04 and 0.02, respectively). The prevalence of @entity4 was significantly higher in the @entity3 group versus the nonpsoriasis group when using Amor or @entity4 Study Group criteria (14.3% versus 1.5%; P   <   0.001). Sudden onset of @entity1 was significantly higher in the @entity3 group (23.3% versus 13.0%; P   =   0.01). CONCLUSION: There is a higher prevalence of lower @entity1 , @entity2 , @entity4 , and alternating buttock @entity1 associated with a prior diagnosis of @entity3 . These data may influence the way @entity3 @entity0 are approached in primary care and specialty clinics.

title: Prevalence of Chronic Axial XXXX , and @entity4 in Diagnosed Psoriasis.

answer: @entity1


abstract: @entity0 infrequently present to the general emergency department with what appears to be a severe @entity1 condition needing rapid differentiation from urgent and emergency medical problems for proper initial disposition and treatment. These include @entity0 with both acute conversion reactions and those in acute @entity4 or pseudocatatonic states. Fifteen consecutive @entity0 (11 @entity0 and four @entity0 ranging in age from 17 to 62) with these symptoms underwent interviews under intravenous @entity5 in the emergency department. Five of these @entity0 presented with acute @entity2 of extremities. Ten presented in a state of vigilant awareness similar to, or identical with, @entity3 . Using this technique, all 15 @entity0 had the presumptive @entity1 nature of their underlying condition quickly confirmed. The five @entity0 with conversion reactions have no recurrence to date. Four of the 10 @entity3 -type @entity0 had resolution of their symptoms without recurrence. All 15 @entity0 responded to 500 mg or less of @entity5 . There were no complications. Two cases are discussed.

title: The emergency XXXX interview.

answer: @entity5


abstract: OBJECTIVE: @entity1 is not always correlated with severity of @entity2 ( @entity2 ), possibly because @entity0 modify activities to manage symptoms. Measures of symptoms that consider @entity1 in the context of activity level may therefore provide greater discrimination than a measure of @entity1 alone. We undertook this study to compare discrimination provided by a measure of @entity1 alone with that provided by combined measures of @entity1 in the context of physical activity across radiographic @entity2 severity levels. METHODS: This was a cross-sectional study nested within the @entity2 ( @entity2 ). The population was drawn from 2,127 @entity0 enrolled in an @entity2 accelerometer monitoring substudy, including those with and those without knee @entity2 . Two composite @entity1 and activity knee symptom (PAKS) scores were calculated as the Western Ontario and McMaster Universities @entity2 Index (WOMAC) @entity1 score (plus 1) divided by a physical activity measure (step count for the first PAKS score [PAKS1 score] and activity count for the second PAKS score [PAKS2 score]). Symptom score discrimination across Kellgren/Lawrence (K/L) grades was evaluated using histograms and quantile regression. RESULTS: A total of 1,806 @entity0 (55.5% of whom were @entity0 ) were included (mean        SD age 65.1      9.1 years, mean        SD body mass index 28.4        4.8 kg/m(2) ). The @entity1 score, but not the PAKS scores, exhibited a floor effect. The adjusted median @entity1 scores by K/L grades 0-4 were 0, 0, 0, 1, and 3, respectively. The adjusted median PAKS1 scores were 24.9, 26.0, 32.4, 46.1, and 97.9, respectively, and the adjusted median PAKS2 scores were 7.2, 7.2, 9.2, 12.9, and 23.8, respectively. The PAKS scores had more statistically significant comparisons between K/L grades than did the @entity1 score. CONCLUSION: Symptom assessments incorporating @entity1 and physical activity did not exhibit a floor effect and were better able to discriminate radiographic severity than an assessment of @entity1 alone, particularly in milder disease. @entity1 in the context of physical activity level should be used to assess knee @entity2 symptoms.

title: Symptom assessment in knee XXXX needs to account for physical activity level.

answer: @entity2


abstract: BACKGROUND: Intravenous lidocaine infusion has been clearly demonstrated as effective for @entity2 in randomized controlled trials, but the belief that cardiac monitoring is required for safe administration is a barrier to access in the palliative care setting. There are also multiple infusion protocols reported in the literature. We have been administering lidocaine infusions for severe @entity1 @entity2 at the BC Cancer Agency (BCCA) since 2003, without electrocardiographic (ECG) monitoring. Our simple protocol is for 5   mg/kg to be infused over 1 hour, with the option for subsequent doses to be increased if necessary, up to a maximum of 10   mg/kg. Our aim with this study is to share 11 years of our experience with this protocol. METHODS: This is a retrospective case series. Records of @entity0 who received at least one lidocaine infusion for @entity2 between 2003 and 2013 at the BCCA were reviewed. The primary end points were the documentation of clinical benefit and adverse effects. RESULTS: A total of 122 lidocaine infusions were administered in 51 individual @entity0 . Twenty-five (49%) had a major response, 12 (23.5%) had a minor response, and 14 (27.5%) were considered nonresponders. Twenty-two (43.1%) @entity0 were noted to have some adverse effect during at least one of the infusions, but only 1 (1.9%) @entity0 had the infusion permanently discontinued. The most common side effects were drowsiness (30.7%), perioral @entity4 (13.4%), @entity3 (5.7%), and minor fluctuations of blood pressure (3.8%). CONCLUSIONS: This case series demonstrates that our protocol of infusional lidocaine can be beneficial to @entity0 with @entity1 with severe @entity2 , and can safely be administered with close observation and vital sign monitoring, without ECG monitoring. Lidocaine infusion is a useful option to consider when other @entity2 treatments have not been successful. Although only approximately half of @entity0 will respond well, there is little harm to be expected from a trial of lidocaine infusion and responders can be repeatedly treated. This treatment could be delivered in palliative care units, hospices, or even @entity0 ' homes, providing suitable nursing supervision can be provided.

title: Intravenous Lidocaine for XXXX without Electrocardiographic Monitoring: A Retrospective Review.

answer: @entity1


abstract: UNASSIGNED: The hormone @entity0 islet amyloid polypeptide ( @entity5 or @entity5 ) plays a role in @entity3 metabolism, but forms amyloid in the @entity4 ( @entity4 ) and is associated with b-cell death and dysfunction in the disease. Inhibitors of islet amyloid have therapeutic potential, however there are no clinically approved inhibitors and the mode of action of existing inhibitors is not well understood. @entity2 @entity6 (rIAPP), differs from @entity5 at six positions, does not form amyloid and is an inhibitor of amyloid formation by @entity5 . Five of the six differences are located within residues 20-29, and three of them are Pro residues, which are well known disruptors of b-sheet structure. rIAPP is thus a natural example of a "b-breaker inhibitor"; a molecule which combines a recognition element with an entity that inhibits b-sheet formation. Pramlintide (PM) is a peptide drug approved for use as an adjunct to insulin therapy for treatment of @entity1 . PM was developed by introducing the three Pro substitutions found in rIAPP into @entity5 . Thus, it more closely resembles the @entity0 peptide than does rIAPP. Here we examine and compare the ability of rIAPP, PM and a set of designed analogs of @entity5 to inhibit amyloid formation by @entity5 , in order to elucidate the factors which lead to effective peptide based inhibitors. Our results reveal, for this class of molecules, a balance between the reduced amyloidogenicity of the inhibitory sequence on the one hand and its ability to recognize @entity5 on the other.

title: Analysis of the Ability of Pramlintide to Inhibit Amyloid Formation by XXXX Islet Amyloid Polypeptide Reveals a Balance between Optimum Recognition and Reduced Amyloidgenicity.

answer: @entity0


abstract: @entity1 remains the principal management challenge for @entity0 with lower risk @entity3 ( @entity3 ). Despite appropriate cytokine production and cellular receptor display, @entity5 ( @entity5 ) signaling is impaired. We reported that @entity5 signaling is dependent upon receptor localization within lipid raft microdomains, and that disruption of raft integrity abolishes signaling capacity. Here, we show that @entity3 erythroid progenitors display markedly diminished raft assembly and smaller raft aggregates compared to normal controls (p=0.005, raft number; p=0.023, raft size). Because @entity6 triggers raft coalescence in T-lymphocytes promoting immune synapse formation, we assessed effects of @entity6 on raft assembly in @entity3 erythroid precursors and @entity0 cells. @entity6 treatment rapidly induced lipid raft formation accompanied by @entity5 recruitment into raft fractions together with @entity7 , @entity4 , and @entity8 kinase. The @entity4 phosphatase, @entity2 , a key negative regulator of @entity5 signaling, was displaced from raft fractions. @entity6 treatment prior to Epo stimulation enhanced both @entity4 and @entity7 phosphorylation in UT7 and primary @entity3 erythroid progenitors, accompanied by increased @entity7 DNA binding in @entity0 cells, and increased erythroid colony forming capacity in both @entity0 and primary cells. Raft induction was associated with F-actin polymerization, which was blocked by Rho kinase inhibition. These data indicate that deficient raft integrity impairs @entity5 signaling, and provides a novel strategy to enhance @entity5 signal fidelity in non-del(5q) @entity3 .

title: @entity6 induces lipid raft assembly to enhance erythropoietin receptor signaling in XXXX progenitors.

answer: @entity3


abstract: @entity1 remains the principal management challenge for @entity0 with lower risk @entity3 ( @entity3 ). Despite appropriate cytokine production and cellular receptor display, @entity5 ( @entity5 ) signaling is impaired. We reported that @entity5 signaling is dependent upon receptor localization within lipid raft microdomains, and that disruption of raft integrity abolishes signaling capacity. Here, we show that @entity3 erythroid progenitors display markedly diminished raft assembly and smaller raft aggregates compared to normal controls (p=0.005, raft number; p=0.023, raft size). Because @entity6 triggers raft coalescence in T-lymphocytes promoting immune synapse formation, we assessed effects of @entity6 on raft assembly in @entity3 erythroid precursors and @entity0 cells. @entity6 treatment rapidly induced lipid raft formation accompanied by @entity5 recruitment into raft fractions together with @entity7 , @entity4 , and @entity8 kinase. The @entity4 phosphatase, @entity2 , a key negative regulator of @entity5 signaling, was displaced from raft fractions. @entity6 treatment prior to Epo stimulation enhanced both @entity4 and @entity7 phosphorylation in UT7 and primary @entity3 erythroid progenitors, accompanied by increased @entity7 DNA binding in @entity0 cells, and increased erythroid colony forming capacity in both @entity0 and primary cells. Raft induction was associated with F-actin polymerization, which was blocked by Rho kinase inhibition. These data indicate that deficient raft integrity impairs @entity5 signaling, and provides a novel strategy to enhance @entity5 signal fidelity in non-del(5q) @entity3 .

title: XXXX induces lipid raft assembly to enhance erythropoietin receptor signaling in @entity3 progenitors.

answer: @entity6


abstract: @entity3 ( @entity3 ) is a heterogeneous group of non-invasive lesions of the breast that result from abnormal proliferation of mammary epithelial cells. Pathologists characterize @entity3 by four tissue morphologies (micropapillary, cribriform, solid, and comedo), but the underlying mechanisms that distinguish the development and progression of these morphologies are not well understood. Here we explored the conditions leading to the emergence of the different morphologies of @entity3 using a two-dimensional multi-cell lattice-based model that incorporates cell proliferation, apoptosis, @entity2 , adhesion, and contractility. We found that the relative rates of cell proliferation and apoptosis governed which of the four morphologies emerged. High proliferation and low apoptosis favored the emergence of solid and comedo morphologies. In contrast, low proliferation and high apoptosis led to the micropapillary morphology, whereas high proliferation and high apoptosis led to the cribriform morphology. The natural progression between morphologies cannot be investigated in vivo since lesions are usually surgically removed upon detection; however, our model suggests probable transitions between these morphologies during @entity0 progression. Importantly, cribriform and comedo appear to be the ultimate morphologies of @entity3 . Motivated by previous experimental studies demonstrating that @entity1 cells behave differently depending on where they are located within the mammary duct in vivo or in engineered tissues, we examined the effects of tissue geometry on the progression of @entity3 . In agreement with our previous experimental work, we found that cells are more likely to invade from the end of ducts and that this preferential invasion is regulated by cell adhesion and contractility. This model provides additional insight into @entity1 cell behavior and allows the exploration of phenotypic transitions not easily monitored in vivo.

title: Lattice-based model of ductal carcinoma in situ suggests rules for XXXX progression to an invasive state.

answer: @entity0


abstract: BACKGROUND: @entity9 ( @entity9 ) used to be a disease restricted to Latin America, but has become a worldwide problem due to @entity3 individuals to developed countries. Electrocardiography has been considered an essential exam to evaluate @entity9 @entity0 . OBJECTIVE: This study sought to identify prevalent @entity6 in a large sample of @entity9 @entity0 evaluated in the primary care setting. METHODS: This retrospective observational study assessed all consecutive digital 12-lead electrocardiograms (ECG) performed by the Telehealth Network of Minas Gerais, Brazil, from January 1 to December 31, 2011. In that time, the service attended primary care @entity0 in 660 cities in the Minas Gerais province. @entity9 was self-reported, and the individuals who did not report having @entity9 were considered noninfected. The prevalence of @entity6 was assessed. RESULTS: Self-reported @entity9 @entity0 comprised 7,590 (2.9%) of 264,324 @entity0 who underwent ECG during the study period. The mean age for @entity9 @entity0 was 57.0    13.7 years, and 64.1% of @entity0 were @entity0 . The most common comorbidities were @entity2 (61.3%), @entity1 (9.1%), and @entity11 (6.9%), and 10.7% were smokers. The most frequent @entity6 were nonspecific repolarization abnormalities (34.6%), @entity5 ( @entity5 ) (22.7%), @entity8 ( @entity8 ) (22.5%), @entity10 (5.4%), and @entity7 (5.4%). Only 31.5% of the @entity0 had no electrocardiographic abnormality versus 61.2% in noninfected individuals (p < 0.001). The prevalence of normal ECG decreased with aging and was significantly lower than for noninfected individuals in all age groups. Pacemaker rhythm (odds ratio [OR]: 13.3, 95% confidence intervals [CI]: 11.5 to 15.4), @entity5 (OR: 10.7, 95% CI: 10.1 to 11.4), especially in association with @entity8 (OR: 12.1, 95% CI: 11.2 to 13.0), second @entity4 (OR: 4.1, 95% CI: 2.5 to 6.6), and third @entity4 (OR: 13.3, 95% CI: 11.5 to 15.4) were strongly related to @entity9 . CONCLUSIONS: In this large sample of primary care @entity0 with @entity9 , there was a high prevalence of @entity6 . Pacemaker rhythm, @entity5 , especially in association with @entity8 , and second and third @entity4 were strongly related to @entity9 .

title: Electrocardiogram and Chagas Disease: A Large Population Database of Primary Care XXXX .

answer: @entity0


abstract: AIM: Dissection of the perineal body (PB) during abdominoperineal excision (APE) for @entity1 is often difficult due to lack of a natural plane of dissection. Understanding of the PB and its relation to the anorectum is essential to permit safe dissection during the perineal phase of the operation, to avoid damage to the anorectum and urogenital organs. This study describes the anatomy and histology of the PB relevant to APE. METHOD: Six @entity0 adult cadaver pelvic exenteration specimens (three males, three females) from the Leeds GIFT Research Tissue Programme were studied. @entity3 -embedded mega-blocks were produced and serially sectioned at 50 and 250  m intervals. Sections were stained by immunohistochemistry to show collagen, @entity4 and smooth muscle. RESULTS: The PB was cylindrically-shaped in males and wedge-shaped in females. Although centrally located between the anal and urogenital triangles, it was nearly completely formed by muscle fibres derived from the @entity5 . Thick bundles of smooth muscle mostly arising from the longitudinal muscle, inserted into the PB and @entity2 ( @entity2 ). The recto-urethralis muscle originated from the PB and separated the anterolateral PB from the urogenital organs. CONCLUSION: Smooth muscle fibres derived from the @entity5 extend into the PB and @entity2 and appear to fix the anorectum. Dissection of the PB during APE is safe only when the smooth muscle fibres that extend into the PB are divided. This article is protected by copyright. All rights reserved.

title: The anatomy of the perineal body in relation to abdominoperineal excision for XXXX .

answer: @entity1


abstract: Epidemiological studies have associated air particulate matter (PM) inhalation with a decline in lung function and increased morbo-mortality due to @entity2 , particularly in susceptible populations. Sj  @entity4 ( @entity4 ) is a chronic @entity6 characterized by cellular infiltration in exocrine glands and extraglandular tissue, being the respiratory tract an important target. We evaluated the effect of PM on the airways of NOD @entity1 , which develop @entity4 and BALB/c @entity1 . BALB/c or NOD @entity1 (2-3 months) were randomized in two groups and exposed to intranasal instillation either with saline (control) or ROFA solution (1mg/kg body weight). After 24h, @entity1 were euthanized in order to perform lung histology, or measure total cell number (TCN), differential cell count (DCC) and @entity3 anion generation in the bronchoalveolar lavage (BAL) fluid. BALB/c @entity1 showed normal histoarchitecture, while NOD @entity1 showed lymphocytic peribronchial infiltrates. ROFA exposure affected the respiratory tract from both BALB/c and NOD @entity1 , with a significant increase in the TCN (p<0.05) and generation of O2(-) (p<0.05), as well as an imbalance in the DCC (p<0.05). All histological observations correlated with the cellular parameters evaluated. Lesions in NOD @entity1 were more severe than those of BALB/c, showing cellular infiltration in the alveoli and leading to a greater decrease in the alveolar space. We have proved that in this experimental Sj  @entity4 animal model (NOD @entity1 ); airborne pollution exacerbates pre-existing @entity5 . These findings show experimental evidence on the harmful effects of airborne pollution on the airways of @entity0 with Sj  @entity4 .

title: Air particulate matter exacerbates lung response on Sj  XXXX animals.

answer: @entity4


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( @entity9 , @entity4 , @entity7 ) Versus Intravenous Therapy ( @entity4 , XXXX , and @entity6 ) in @entity0 With @entity2 : A Randomized Phase II Study of GFPC 0501.

answer: @entity3


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( @entity9 , @entity4 , @entity7 ) Versus Intravenous Therapy ( @entity4 , @entity3 , and XXXX ) in @entity0 With @entity2 : A Randomized Phase II Study of GFPC 0501.

answer: @entity6


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( @entity9 , XXXX , @entity7 ) Versus Intravenous Therapy ( @entity4 , @entity3 , and @entity6 ) in @entity0 With @entity2 : A Randomized Phase II Study of GFPC 0501.

answer: @entity4


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( @entity9 , @entity4 , @entity7 ) Versus Intravenous Therapy ( XXXX , @entity3 , and @entity6 ) in @entity0 With @entity2 : A Randomized Phase II Study of GFPC 0501.

answer: @entity4


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( @entity9 , @entity4 , @entity7 ) Versus Intravenous Therapy ( @entity4 , @entity3 , and @entity6 ) in @entity0 With XXXX : A Randomized Phase II Study of GFPC 0501.

answer: @entity2


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( XXXX , @entity4 , @entity7 ) Versus Intravenous Therapy ( @entity4 , @entity3 , and @entity6 ) in @entity0 With @entity2 : A Randomized Phase II Study of GFPC 0501.

answer: @entity9


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( @entity9 , @entity4 , XXXX ) Versus Intravenous Therapy ( @entity4 , @entity3 , and @entity6 ) in @entity0 With @entity2 : A Randomized Phase II Study of GFPC 0501.

answer: @entity7


abstract: BACKGROUND: No reference second-line treatment of @entity2 is available. The aim of the present phase II randomized trial (Groupe Fran  ais de Pneumo-Canc  rologie 0501) was to compare, in @entity0 with progressive @entity2 after first-line @entity5 -based chemotherapy, oral multidrug chemotherapy ( @entity9 , @entity4 , @entity7 ) and intravenous therapy with @entity4 , @entity3 , and @entity6 ( @entity8 ) in terms of efficacy and tolerance. The primary endpoint was overall survival. The secondary endpoints were progression-free survival, response rate, and tolerance. @entity0 AND METHODS: The study randomized 131 @entity0 (76.7% male; median age, 61    8.1 years, 85.5% with a performance status of 0-1), 65 to oral therapy and 66 to the @entity8 arm. No statistically significant differences were found in the baseline @entity0 characteristics. RESULTS: The OS and PFS was 6.1 and 3 months for the oral arm and 5.8 and 3.1 months for the @entity8 arm, respectively. The control disease rate was 61.6% and 45.5% in oral and @entity8 arms, respectively. No unexpected adverse events occurred, and no statistically significant difference was found between the 2 arms in terms of @entity1 (grade 4 hematologic adverse events in 32.3% and 31.8% of @entity0 in the oral and @entity8 arms, respectively). CONCLUSION: Compared with @entity8 , oral therapy in this setting appears as feasible as, but not superior to, the efficacy in the @entity8 arm.

title: Second-Line Oral Chemotherapy ( @entity9 , @entity4 , @entity7 ) Versus Intravenous Therapy ( @entity4 , @entity3 , and @entity6 ) in XXXX With @entity2 : A Randomized Phase II Study of GFPC 0501.

answer: @entity0


abstract: Surveys indicate that substance use is prevalent in populations with @entity1 . Family members may be able to support brief interventions (BI). We conducted a randomised controlled trial with 6-month follow-up among adult @entity0 with @entity1 and related @entity5 who were referred to two hospitals in southern Thailand. @entity0 with @entity4 were screened using the @entity2 Smoking and Substance Involvement Screening Test (ASSIST). 169 @entity0 (all at moderate substance risk on the ASSIST) were randomised to receive simple advice (the clinics' treatment-as-usual, TAU condition), or single-session brief intervention (BI), or a single-session BI with family support (BI-FS). Given observed substance use, the primary outcome was the ASSIST @entity3 smoking involvement score (SIS). Secondary outcomes were cigarettes smoked per day, change motivation (Taking Steps from the Stages of Change and Treatment Eagerness Scale), and DSM-IV Axis V Global Assessment of Relational Functioning (GARF). At follow-up, BI-FS @entity0 reported a lower SIS (mean difference, -2.82, 95% confidence interval [CI] -4.84 to -0.81; Glass' effect size [  ]=0.57, 95% CI 0.19 to 0.95), smoked fewer cigarettes per day (mean difference -3.10, 95% CI -5.45 to -0.74;   =0.56, 95% CI 0.18 to 0.94), had greater change motivation (mean difference 3.05, 95% CI 0.54 to 5.57;   =0.41, 95% CI 0.03 to 0.79) and GARF (mean difference 6.75, 95% CI 1.57 to 11.93;   =0.54, 95% CI 0.16 to 0.92). The BI-FS group also had better relational functioning in comparison to those receiving BI only (mean difference 5.44, 95% CI 0.20 to 10.67;   =0.46, 95% CI 0.08 to 0.84). In @entity1 and related @entity5 , a brief intervention supported by a family member reduces smoking involvement, cigarette smoking intensity, and increases change motivation and relational functioning.

title: Effects of a Brief Intervention for Substance Use on @entity3 Smoking and Family Relationship Functioning in XXXX and Related Psychoses: A Randomised Controlled Trial.

answer: @entity1


abstract: Surveys indicate that substance use is prevalent in populations with @entity1 . Family members may be able to support brief interventions (BI). We conducted a randomised controlled trial with 6-month follow-up among adult @entity0 with @entity1 and related @entity5 who were referred to two hospitals in southern Thailand. @entity0 with @entity4 were screened using the @entity2 Smoking and Substance Involvement Screening Test (ASSIST). 169 @entity0 (all at moderate substance risk on the ASSIST) were randomised to receive simple advice (the clinics' treatment-as-usual, TAU condition), or single-session brief intervention (BI), or a single-session BI with family support (BI-FS). Given observed substance use, the primary outcome was the ASSIST @entity3 smoking involvement score (SIS). Secondary outcomes were cigarettes smoked per day, change motivation (Taking Steps from the Stages of Change and Treatment Eagerness Scale), and DSM-IV Axis V Global Assessment of Relational Functioning (GARF). At follow-up, BI-FS @entity0 reported a lower SIS (mean difference, -2.82, 95% confidence interval [CI] -4.84 to -0.81; Glass' effect size [  ]=0.57, 95% CI 0.19 to 0.95), smoked fewer cigarettes per day (mean difference -3.10, 95% CI -5.45 to -0.74;   =0.56, 95% CI 0.18 to 0.94), had greater change motivation (mean difference 3.05, 95% CI 0.54 to 5.57;   =0.41, 95% CI 0.03 to 0.79) and GARF (mean difference 6.75, 95% CI 1.57 to 11.93;   =0.54, 95% CI 0.16 to 0.92). The BI-FS group also had better relational functioning in comparison to those receiving BI only (mean difference 5.44, 95% CI 0.20 to 10.67;   =0.46, 95% CI 0.08 to 0.84). In @entity1 and related @entity5 , a brief intervention supported by a family member reduces smoking involvement, cigarette smoking intensity, and increases change motivation and relational functioning.

title: Effects of a Brief Intervention for Substance Use on XXXX Smoking and Family Relationship Functioning in @entity1 and Related Psychoses: A Randomised Controlled Trial.

answer: @entity3


abstract: The electrical excitability of uterine smooth muscle cells is a key determinant of the contraction of the organ during labor and is manifested by spontaneous, periodic @entity0 ( @entity0 ). Near the end of term, @entity0 vary in shape and size reflecting an ability to change the frequency, duration and amplitude of uterine contractions. A recent mathematical model quantified several ionic features of the electrical excitability in uterine smooth muscle cells. It replicated many of the experimentally recorded uterine AP configurations but its limitations were evident when trying to simulate the long-duration bursting @entity0 characteristic of labor. A computational parameter search suggested that delayed rectifying K+ currents could be a key model component requiring improvement to produce the longer-lasting bursting @entity0 . Of the delayed rectifying K+ currents family it is of interest that KCNQ and @entity2 channels have been reported to be gestationally regulated in the uterus. These currents exhibit features similar to the broadly defined uterine @entity1 of the original mathematical model. We thus formulated new quantitative descriptions for several IKCNQ and IhERG. Incorporation of these currents into the uterine cell model enabled simulations of the long-lasting bursting @entity0 . Moreover, we used this modified model to simulate the effects of different contributions of IKCNQ and IhERG on AP form. Our findings suggest that the alterations in expression of @entity2 and KCNQ channels can potentially provide a mechanism for fine tuning of AP forms that lends a malleability for changing between plateau-like and long-lasting bursting-type @entity0 as uterine cells prepare for parturition.

title: Computational Modeling Reveals Key Contributions of KCNQ and XXXX Currents to the Malleability of Uterine Action Potentials Underpinning Labor.

answer: @entity2


abstract: BACKGROUND: Identifying protein-protein interactions (PPIs) is essential for elucidating protein functions and understanding the molecular mechanisms inside the cell. However, the experimental methods for detecting PPIs are both time-consuming and expensive. Therefore, computational prediction of protein interactions are becoming increasingly popular, which can provide an inexpensive way of predicting the most likely set of interactions at the entire proteome scale, and can be used to complement experimental approaches. Although much progress has already been achieved in this direction, the problem is still far from being solved and new approaches are still required to overcome the limitations of the current prediction models. RESULTS: In this work, a sequence-based approach is developed by combining a novel @entity2 ( @entity2 ) feature representation and Support Vector Machine (SVM). The @entity2 representation gives adequate consideration to the interactions between sequentially distant but spatially close @entity1 residues, thus it can sufficiently capture multiple overlapping continuous and discontinuous binding patterns within a protein sequence. An effective feature selection method mRMR was employed to construct an optimized and more discriminative feature set by excluding redundant features. Finally, a prediction model is trained and tested based on SVM algorithm to predict the interaction probability of protein pairs. CONCLUSIONS: When performed on the @entity0 PPIs data set, the proposed approach achieved 91.36% prediction accuracy with 91.94% precision at the sensitivity of 90.67%. Extensive experiments are conducted to compare our method with the existing sequence-based method. Experimental results show that the performance of our predictor is better than several other state-of-the-art predictors, whose average prediction accuracy is 84.91%, sensitivity is 83.24%, and precision is 86.12%. Achieved results show that the proposed approach is very promising for predicting PPI, so it can be a useful supplementary tool for future proteomics studies. The source code and the datasets are freely available at http://csse.szu.edu.cn/staff/youzh/MCDPPI.zip for academic use.

title: Prediction of protein-protein interactions from XXXX sequences using a novel multi-scale continuous and discontinuous feature set.

answer: @entity1


abstract: During a 22-year period 224 @entity0 were seen for treatment of transitional cell @entity3 . Of these @entity0 49 (22 per cent) had grade 1 lesions. Followup ranged from 5 to 25 years. The most common symptom was @entity4 . In only 54 per cent of the 49 @entity0 was a filling defect noted on excretory urography. Forty-seven @entity0 (96 per cent) had stage I disease. Treatment included total nephroureterectomy, nephrectomy or segmental resection. In 11 @entity0 (23 per cent) evidence of @entity2 developed 8 months to 12 years (average 4 years) after the diagnosis of @entity1 of the upper urinary tract and 73 per cent of these recurrences were noted within the first 3 years. In 1 @entity0 a @entity1 developed in the opposite upper urinary tract. In only 1 of 15 @entity0 who had had partial ureterectomy or local excision @entity1 developed in the ipsilateral ureter. @entity0 survival time was identical to that in an age-matched control group. We conclude that the most significant findings are the subsequent high incidence (23 per cent) of @entity2 and the comparable survival in these pateints and in an age-matched control group. Furthermore, these results suggest that operations preserving the renal parenchyma, that is segmental resection, should be used more frequently.

title: Primary grade 1 transitional cell XXXX .

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: @entity0 is an @entity11 . This is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. However, liver has an anti-inflammatory microenvironment. Myelin expression in the liver of @entity1 suppresses inflammatory lesions within central nervous system. Considering the notion that the inflammatory events originate from periphery, we investigated if the liver was affected in an animal model for @entity0 . METHODS: Experimental autoimmune @entity8 was induced in male Lewis @entity2 using @entity7 spinal cord and complete Freund's adjuvant. Weight, clinical score, and survival rate were evaluated for 14 days post immunization. Liver sections were taken and stained with @entity9 and @entity10 and examined with an Olympus microscope. RESULTS: Mortality was accompanied by @entity5 . Sinusoidal congestion, pycnotic nuclei within hepatocytes, hepatocyte @entity3 , and severe widespread congestion along with fat accumulation within hepatocytes ( @entity6 ) were observed in liver tissue sections. CONCLUSION: @entity5 occurs in experimental autoimmune @entity8 . The perpetuation of self antigen leading to continuous migration of extrahepatically activated T cells makes an inflammatory milieu in the liver. It follows migration and development of more inflammatory cells and may paralyses tolerance inducing mechanisms. Apart from @entity11 , @entity4 may act as synergistic factor for debilitation and mortality.

title: XXXX and Mortality in a Male Lewis @entity2 of Experimental Autoimmune @entity8 .

answer: @entity5


abstract: BACKGROUND AND OBJECTIVES: @entity0 is an @entity11 . This is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. However, liver has an anti-inflammatory microenvironment. Myelin expression in the liver of @entity1 suppresses inflammatory lesions within central nervous system. Considering the notion that the inflammatory events originate from periphery, we investigated if the liver was affected in an animal model for @entity0 . METHODS: Experimental autoimmune @entity8 was induced in male Lewis @entity2 using @entity7 spinal cord and complete Freund's adjuvant. Weight, clinical score, and survival rate were evaluated for 14 days post immunization. Liver sections were taken and stained with @entity9 and @entity10 and examined with an Olympus microscope. RESULTS: Mortality was accompanied by @entity5 . Sinusoidal congestion, pycnotic nuclei within hepatocytes, hepatocyte @entity3 , and severe widespread congestion along with fat accumulation within hepatocytes ( @entity6 ) were observed in liver tissue sections. CONCLUSION: @entity5 occurs in experimental autoimmune @entity8 . The perpetuation of self antigen leading to continuous migration of extrahepatically activated T cells makes an inflammatory milieu in the liver. It follows migration and development of more inflammatory cells and may paralyses tolerance inducing mechanisms. Apart from @entity11 , @entity4 may act as synergistic factor for debilitation and mortality.

title: @entity5 and Mortality in a Male Lewis @entity2 of Experimental Autoimmune XXXX .

answer: @entity8


abstract: BACKGROUND AND OBJECTIVES: @entity0 is an @entity11 . This is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. However, liver has an anti-inflammatory microenvironment. Myelin expression in the liver of @entity1 suppresses inflammatory lesions within central nervous system. Considering the notion that the inflammatory events originate from periphery, we investigated if the liver was affected in an animal model for @entity0 . METHODS: Experimental autoimmune @entity8 was induced in male Lewis @entity2 using @entity7 spinal cord and complete Freund's adjuvant. Weight, clinical score, and survival rate were evaluated for 14 days post immunization. Liver sections were taken and stained with @entity9 and @entity10 and examined with an Olympus microscope. RESULTS: Mortality was accompanied by @entity5 . Sinusoidal congestion, pycnotic nuclei within hepatocytes, hepatocyte @entity3 , and severe widespread congestion along with fat accumulation within hepatocytes ( @entity6 ) were observed in liver tissue sections. CONCLUSION: @entity5 occurs in experimental autoimmune @entity8 . The perpetuation of self antigen leading to continuous migration of extrahepatically activated T cells makes an inflammatory milieu in the liver. It follows migration and development of more inflammatory cells and may paralyses tolerance inducing mechanisms. Apart from @entity11 , @entity4 may act as synergistic factor for debilitation and mortality.

title: @entity5 and Mortality in a Male Lewis XXXX of Experimental Autoimmune @entity8 .

answer: @entity2


abstract: INTRODUCTION: Platelets play an important role in @entity1 . Mean platelet volume ( @entity3 ) may be a useful parameter for inflammatory conditions, in differentiating between non-specific @entity2 (NSAP) and conditions requiring surgery, or early diagnosis of @entity2 as a serious problem for emergency services. AIM: To investigate the role of @entity3 on NSAP admittance to the emergency department. MATERIAL AND METHODS: The study consisted of 330 @entity0 (186 female and 144 male, with mean age 49   20 years) with NSAP and 249 @entity0 with @entity2 (144 female and 105 male, with mean age 49   19 years) applied to our emergency service and enrolled to our study. Medical history, physical examination, complete blood count (CBC), and biochemical parameters were evaluated. Haematological parameters were measured by Beckman Coulter LH 780 instrument. Data were compared using Student's t test, and p < 0.05 was accepted as statistically significant. RESULTS: The @entity3 were significantly lower in @entity0 with NSAP than in others (p = 0.025). There was no significant difference between both sexes with regard to @entity3 (p > 0.05). Moreover, the other haematological parameters (haemoglobin, platelet, or WBC counts) were not statistically different between both groups (p > 0.05). CONCLUSIONS: The @entity3 may be a useful, simple, and inexpensive parameter to diagnose or differentiate between NSAP and other conditions.

title: The role of mean platelet volume in @entity0 with non-specific XXXX in an emergency department.

answer: @entity2


abstract: INTRODUCTION: Platelets play an important role in @entity1 . Mean platelet volume ( @entity3 ) may be a useful parameter for inflammatory conditions, in differentiating between non-specific @entity2 (NSAP) and conditions requiring surgery, or early diagnosis of @entity2 as a serious problem for emergency services. AIM: To investigate the role of @entity3 on NSAP admittance to the emergency department. MATERIAL AND METHODS: The study consisted of 330 @entity0 (186 female and 144 male, with mean age 49   20 years) with NSAP and 249 @entity0 with @entity2 (144 female and 105 male, with mean age 49   19 years) applied to our emergency service and enrolled to our study. Medical history, physical examination, complete blood count (CBC), and biochemical parameters were evaluated. Haematological parameters were measured by Beckman Coulter LH 780 instrument. Data were compared using Student's t test, and p < 0.05 was accepted as statistically significant. RESULTS: The @entity3 were significantly lower in @entity0 with NSAP than in others (p = 0.025). There was no significant difference between both sexes with regard to @entity3 (p > 0.05). Moreover, the other haematological parameters (haemoglobin, platelet, or WBC counts) were not statistically different between both groups (p > 0.05). CONCLUSIONS: The @entity3 may be a useful, simple, and inexpensive parameter to diagnose or differentiate between NSAP and other conditions.

title: The role of mean platelet volume in XXXX with non-specific @entity2 in an emergency department.

answer: @entity0


abstract: This @entity0 is a 48-day-old @entity0 , born as the third @entity0 from a 29-year-old healthy mother. The pregnancy was uneventful, and the delivery was normal. Right after birth, she had episode of @entity4 for several minutes. Her weight of birth was 2,600 g, and the head circumference was 30.4 cm. @entity3 and cyanosis after feeding were noted on the second day. At the time of admission to our service, she showed typical symptoms of "cri-du- @entity7 " syndrome, namely, characteristic cry, @entity2 (DQ was 48), @entity6 (head circumference was 34.5 cm), rounded face, @entity8 , oblique palpebral fissures, epicanthus, @entity9 , @entity5 , short neck, simian crease. Other abnormalities such as @entity11 , prolapsus ani, @entity1 , and @entity10 . Cerebral angiogram demonstrated no pathological findings. Pneumoencephalogram showed accumulation of air at the cranial base. Operation was performed for repair of @entity10 at the age of 50 days. Postoperative course was smooth.

title: [A case of "cri-du- @entity7 " syndrome with XXXX (author's transl)].

answer: @entity10


abstract: This @entity0 is a 48-day-old @entity0 , born as the third @entity0 from a 29-year-old healthy mother. The pregnancy was uneventful, and the delivery was normal. Right after birth, she had episode of @entity4 for several minutes. Her weight of birth was 2,600 g, and the head circumference was 30.4 cm. @entity3 and cyanosis after feeding were noted on the second day. At the time of admission to our service, she showed typical symptoms of "cri-du- @entity7 " syndrome, namely, characteristic cry, @entity2 (DQ was 48), @entity6 (head circumference was 34.5 cm), rounded face, @entity8 , oblique palpebral fissures, epicanthus, @entity9 , @entity5 , short neck, simian crease. Other abnormalities such as @entity11 , prolapsus ani, @entity1 , and @entity10 . Cerebral angiogram demonstrated no pathological findings. Pneumoencephalogram showed accumulation of air at the cranial base. Operation was performed for repair of @entity10 at the age of 50 days. Postoperative course was smooth.

title: [A case of "cri-du- XXXX " syndrome with @entity10 (author's transl)].

answer: @entity7


abstract: BACKGROUND: Accurate assessment of @entity1 is associated with improved @entity1 management, which can lead to better @entity0 outcomes. It has been recommended that all @entity0 have their @entity1 assessed and the scores documented as the 'fifth vital sign'. METHOD: All inpatients in the medical and surgical wards in our hospital were asked directly to score their @entity1 according to the hospital-wide scoring system. Their observation charts and drug charts were then reviewed in order to determine the accuracy of documented @entity1 assessments and the subsequent analgesic management. RESULTS: Of the 208 @entity0 reviewed, 20 (15%) @entity0 on medical wards and 26 (38%) @entity0 on surgical wards were in moderate to severe @entity1 . Documentation of @entity1 scores was not universal, with 29 (14%) @entity0 having no score documented with their last set of observations. Of those with a score recorded, it was not found to correlate with the scores reported on direct questioning in 41% of medical @entity0 and 71% of surgical @entity0 . Provision of analgesia was also found to differ between medical and surgical wards. DISCUSSION: The care of @entity1 in the wards falls below the standards set by the Royal College of Anaesthetists. It is necessary to undertake a programme of education to increase awareness of the problem and to improve assessment and management to enhance the @entity0 experience.

title: A prospective audit project into the adequacy of XXXX assessment in the medical and surgical wards in a North London District General Hospital.

answer: @entity1


abstract: BACKGROUND: Previous studies indicated that @entity0 from Black, Asian and minority ethnic (BAME) groups tend to receive less analgesics compared to Caucasian (White) @entity0 after similar surgical procedures. Most such data originated from North America and suggested that health-care professionals may perceive the expression of excessive @entity1 by BAME @entity0 groups as an exaggerated response to @entity1 , rather than sub-optimal treatment. There are limited data comparing acute @entity1 management between South Asian and White British @entity0 . OBJECTIVE: We aimed to investigate correlation between @entity0 ' ethnicity and disparities of early post-operative @entity1 perception/management, in an ethnically diverse population. METHODS: We conducted a retrospective case note review of acute post-operative @entity1 after total abdominal hysterectomy (TAH) in 60 South Asian and 60 age-matched White British females. Data for 140 variables (pre-, intra- and post-operative) for each @entity0 were recorded. We used propensity score matching to produce 30 closely matched @entity0 in each group minimizing effects of recorded co-variates. Data were analysed with and without propensity score matching. RESULTS: There were no significant differences in acute post-operative @entity1 scores, @entity2 requirements, @entity1 management, adverse effects or duration of post-operative care unit stay between South Asian and White British @entity0 . The median duration of hospital stay of South Asian @entity0 was longer (4.5   days versus 3.0   days, p   <   0.001). CONCLUSION: We conclude that in an institution where both @entity0 and health-care professionals are from an ethnically diverse population, neither post-operative @entity1 nor @entity1 management are influenced significantly by South Asian ethnicity.

title: Influence of ethnicity on the perception and treatment of early post-operative XXXX .

answer: @entity1


abstract: AIM: This study aims to evaluate the relationship between @entity1 ( @entity1 ) times and CHA2DS2-VASc scores in @entity0 diagnosed with @entity1 ( @entity1 ). MATERIALS AND METHODS: The study included a total of 74 @entity0 , 34 of whom were diagnosed with @entity1 and 40 were included in the control group. The CHA2DS2-VASc score was calculated for each @entity0 . Additionally, blood samples were taken from all @entity0 and transthoracic echocardiographic measurements were made. Left atrial mechanical functions and @entity1 were calculated. RESULTS: Mean CHA2DS2-VASc score measured was 2.24      1.53 in @entity1 group. There was no significant difference between the groups when the @entity0 were evaluated for baseline characteristics and laboratory parameters (P  >  0.05) The echocardiographic evaluation of LA mechanical functions showed that only LA minimum volume (19      6.4 vs. 16.7      4.6, P  =  0.02) and LA presystolic volume (28.9      7 vs. 25.1      5.7, P  =  0.01) were higher in the @entity1 group. When @entity1 was compared between the groups; lateral PA, septal PA, tricuspid PA, Interatrial EMD, and intraatrial EMD were significantly extended compared to control group (P  <  0.001) CHA2DS2-VASc score was correlated with Lateral atrial PA (P  <  0.001, r  =  0.524), Septal atrial PA (P  <  0.001, r  =  0.45), Interatrial EMD (P  <  0.001, r  =  0.54), and intraatrial EMD (P  <  0.001, r  =  0.51) times. CONCLUSION: The present study shows that @entity1 times increase in @entity0 with @entity1 compared to the control group. Furthermore, this study revealed a correlation between @entity1 times and CHA2DS2-VASc score, as well showed that extended @entity1 time may be associated with @entity2 risk.

title: The Relationships between Atrial Electromechanical Delay and CHA2DS2-VASc Score in XXXX Diagnosed with Paroxysmal AF.

answer: @entity0


abstract: @entity14 is considered to occur exclusively in non-fibrotic livers. It is a heterogeneous entity and a molecular classification is now widely accepted. The most frequent hepatocellular @entity7 subtype, namely inflammatory @entity7 , harbor somatic activating mutations of genes involved in the @entity6 pathway that lead to high @entity8 and serum amyloid A expression. The aim of our study was to investigate a series of @entity1 developed on cirrhotic livers and characterized by an unequivocal histological diagnosis. We performed a clinical, pathological, and molecular study of 10 @entity1 developed in three @entity0 with @entity2 . Markers allowing hepatocellular @entity7 classification were assessed by quantitative real-time PCR and immunohistochemistry. Samples were sequenced for @entity11 , @entity13 , @entity15 , @entity9 , @entity12 , and @entity10 (promoter) mutations. A control series of 32 classical macronodules developed in @entity2 related to various etiologies was screened by immunohistochemistry and gene sequencing. The three @entity0 had @entity2 related to @entity3 and/or @entity4 intake; two had a @entity1 , while the third developed more than 30 lesions. Microscopic examination showed well-differentiated @entity1 sharing features with inflammatory @entity7 including inflammatory infiltrates, @entity5 , and dystrophic vessels. Sequencing revealed classical hotspot somatic mutations ( @entity15 , n=8; @entity12 , n=1; and @entity9 , n=1) known to be responsible for @entity6 /JAK/STAT pathway activation. Two classical high-grade macronodules demonstrated high serum amyloid A and/or @entity8 expression, without gene mutations. Altogether, our findings support the existence of rare inflammatory @entity7 developed in @entity2 .

title: XXXX developed in the setting of chronic liver disease and @entity2 .

answer: @entity14


abstract: @entity14 is considered to occur exclusively in non-fibrotic livers. It is a heterogeneous entity and a molecular classification is now widely accepted. The most frequent hepatocellular @entity7 subtype, namely inflammatory @entity7 , harbor somatic activating mutations of genes involved in the @entity6 pathway that lead to high @entity8 and serum amyloid A expression. The aim of our study was to investigate a series of @entity1 developed on cirrhotic livers and characterized by an unequivocal histological diagnosis. We performed a clinical, pathological, and molecular study of 10 @entity1 developed in three @entity0 with @entity2 . Markers allowing hepatocellular @entity7 classification were assessed by quantitative real-time PCR and immunohistochemistry. Samples were sequenced for @entity11 , @entity13 , @entity15 , @entity9 , @entity12 , and @entity10 (promoter) mutations. A control series of 32 classical macronodules developed in @entity2 related to various etiologies was screened by immunohistochemistry and gene sequencing. The three @entity0 had @entity2 related to @entity3 and/or @entity4 intake; two had a @entity1 , while the third developed more than 30 lesions. Microscopic examination showed well-differentiated @entity1 sharing features with inflammatory @entity7 including inflammatory infiltrates, @entity5 , and dystrophic vessels. Sequencing revealed classical hotspot somatic mutations ( @entity15 , n=8; @entity12 , n=1; and @entity9 , n=1) known to be responsible for @entity6 /JAK/STAT pathway activation. Two classical high-grade macronodules demonstrated high serum amyloid A and/or @entity8 expression, without gene mutations. Altogether, our findings support the existence of rare inflammatory @entity7 developed in @entity2 .

title: @entity14 developed in the setting of chronic liver disease and XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity5 following @entity6 are debilitating and difficult to treat. Commonly employed initial therapeutic modalities include pharmacologic, physical, and psychological interventions. Despite these efforts, a subset of @entity0 with @entity4 remains. Peripheral nerve surgery has never before been reported as an effective treatment for the management of post- @entity6 @entity2 . In this study, we report on our early outcomes following peripheral nerve surgery for this novel indication. METHODS: A retrospective review of 28 consecutive @entity0 with post- @entity6 @entity2 who underwent occipital nerve surgery was performed. Preoperative and postoperative @entity3 was evaluated on visual analog scale (VAS) in 24 @entity0 with at least 6 months follow-up. RESULTS: The average VAS @entity3 reduced from 6.4 preoperatively, to 1.4 (P   <   0.0001). Twenty-one @entity0 (88%) had a successful outcome of at least a 50% reduction in their VAS following peripheral nerve surgery. Additionally, twelve @entity0 (50%) were @entity3 free at time of final follow-up. There were no surgical complications. CONCLUSIONS: Early results indicate peripheral nerve surgery is a safe and effective new therapy for post- @entity6 @entity2 in the properly selected @entity0 , whose @entity4 persists despite initial treatments by a neurologist, specialized in @entity2 management. Future studies should focus on larger @entity0 populations, and examine the long-term durability of outcome. In the meantime, an interdisciplinary approach involving neurologists and a peripheral nerve surgeon is suggested for the care of @entity0 with refractory chronic post- @entity6 @entity1 and other post-traumatic @entity5 .    2015 Wiley Periodicals, Inc. Microsurgery, 2015.

title: Interdisciplinary treatment of post- @entity6 and post-traumatic XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity5 following @entity6 are debilitating and difficult to treat. Commonly employed initial therapeutic modalities include pharmacologic, physical, and psychological interventions. Despite these efforts, a subset of @entity0 with @entity4 remains. Peripheral nerve surgery has never before been reported as an effective treatment for the management of post- @entity6 @entity2 . In this study, we report on our early outcomes following peripheral nerve surgery for this novel indication. METHODS: A retrospective review of 28 consecutive @entity0 with post- @entity6 @entity2 who underwent occipital nerve surgery was performed. Preoperative and postoperative @entity3 was evaluated on visual analog scale (VAS) in 24 @entity0 with at least 6 months follow-up. RESULTS: The average VAS @entity3 reduced from 6.4 preoperatively, to 1.4 (P   <   0.0001). Twenty-one @entity0 (88%) had a successful outcome of at least a 50% reduction in their VAS following peripheral nerve surgery. Additionally, twelve @entity0 (50%) were @entity3 free at time of final follow-up. There were no surgical complications. CONCLUSIONS: Early results indicate peripheral nerve surgery is a safe and effective new therapy for post- @entity6 @entity2 in the properly selected @entity0 , whose @entity4 persists despite initial treatments by a neurologist, specialized in @entity2 management. Future studies should focus on larger @entity0 populations, and examine the long-term durability of outcome. In the meantime, an interdisciplinary approach involving neurologists and a peripheral nerve surgeon is suggested for the care of @entity0 with refractory chronic post- @entity6 @entity1 and other post-traumatic @entity5 .    2015 Wiley Periodicals, Inc. Microsurgery, 2015.

title: Interdisciplinary treatment of post- XXXX and post-traumatic @entity2 .

answer: @entity6


abstract: UNASSIGNED: @entity8 (ANP) and @entity9 ( @entity9 ) bind to the receptor guanylyl cyclase (GC)-A, leading to diuresis, natriuresis, and @entity3 . In addition, ANP and @entity9 have various angiogenic properties in @entity1 tissue. When breeding @entity0 devoid of @entity10 , we noted significant skewing of the Mendelian ratio in the offspring, suggesting @entity5 due to knockout of @entity10 . Consequently, we here investigated the roles of endogenous ANP and @entity9 in @entity5 and organ morphogenesis. Embryos resulting from @entity10 (-/-) * @entity10 (+/-) crosses developed @entity6 ( @entity6 ) beginning at embryonic day (E)14.5. All embryos with @entity6 had the genotype @entity10 (-/-). At E17.5, 33.3% (12 of 36) of @entity10 (-/-) embryos had @entity6 , and all @entity10 (-/-) embryos with @entity6 were dead. Beginning at E16.0, @entity6 - @entity10 (-/-) embryos demonstrated poorly developed superficial vascular vessels and sc @entity4 , the fetal side of the placenta appeared @entity1 , and vitelline vessels on the yolk sac were poorly developed. Furthermore, @entity6 - @entity10 (-/-) embryos also showed abnormal constriction of umbilical cord vascular vessels, few cardiac trabeculae and a thin compact zone, @entity2 , and poor bone development. Electron microscopy of E16.5 @entity6 - @entity10 (-/-) embryos revealed severe @entity7 in endothelial cells, and the expected 3-layer structure of the smooth muscle wall of the umbilical artery was indistinct. These data demonstrate the importance of the endogenous ANP/ @entity9 - @entity10 system not only in the neovascularization of @entity1 tissues but also in embryonic vascular development and organ morphogenesis.

title: Importance of Endogenous Atrial and Brain Natriuretic Peptides in XXXX Embryonic Vascular and Organ Development.

answer: @entity0


abstract: OBJECTIVE: To study the clinical effect of arthroscopic excision of @entity6 through a combined anterior and posterior approach. METHODS: From January 2010 to December 2012,20 @entity0 with @entity6 were treated with arthroscopic excision. There were 14 males and 6 females, with an average age of 49.5 years old, ranging from 45 to 65 years old. The lump has been found for 4 to 18 months,with a mean time of 12 months. Their mean sagittal diameter was 4.5 cm (ranged from 3 to 7 cm). There were 12 @entity6 in the left and 8 @entity6 in the right. The main clinical manifestation included lump at popliteal fossa, swelling and @entity3 at knee joint and some extent of dysfunction. All diagnoses were determined according to MRI, which clearly showed the communication of @entity1 . The cyst was removed under arthroscopy, through the posterior approach and then the @entity2 was treated via the anterior approach. According to Rauschning and Lindgren classification, 2 @entity0 were grade I, 6 @entity0 were grade II, and 12 @entity0 were grade III. The guidelines of Rauschning and Lindgren were used to evaluate the clinical effects. RESULTS: No complications such as the @entity5 , or incision @entity4 occurred in all @entity0 . All the @entity0 were followed up, and the duration ranged from 8 to 24 months, with a mean time of 16 months. According to the criteria of Rauschning and Lindgren, there were 14 cases of grade 0, and 6 cases of grade I after operation, which was improved obviously compared with that pre-operation. No cyst reoccurred and the knee joint @entity3 was relieved. CONCLUSION: Treatment of @entity6 with arthroscopic excision through a combined anterior and posterior approach is effective to remove the cyst sac and treat intra-articular diseases simultaneously, resulting in the decrease recurrence rate of cyst.

title: [Extracapsular arthroscopic excision of XXXX through anterior combined with posterior approach].

answer: @entity6


abstract: OBJECTIVE: To study clinical effects of inversive @entity1 ( @entity1 , @entity1 ) plate combined with steel wire for the treatment of @entity6 . METHODS: From January 2009 to Janurary 2012, 11 @entity0 with @entity6 were treated with inversive @entity1 plate combined with steel wire, including 8 males and 3 females, ranging in age from 35 to 61 years old (averaged, 51 years old). Causes of injury: 8 @entity0 caused by accident and 3 @entity0 caused by falling down. According to X-ray examination, all the @entity0 were @entity6 and were treated with @entity1 plate combined with steel wire. Merle d'Aubigne scores were used to evaluate therapeutic effects on hip. RESULTS: The mean period of follow-up was 16 months (ranged, 12 to 28 months). All the @entity0 obtained bone union for average 3.8 months (ranged from 3 to 4.3 months). There were no complications such as @entity3 , @entity4 , @entity5 and bone nonunion. According to Merle d'Aubigne scores, 7 @entity0 got an excellent result and 4 good. CONCLUSION: Inversive @entity1 plate combined with steel wire for the treatment of @entity6 is satisfactory, Which can provide stable fixation for @entity2 end and provide an ideal internal fixation method for treatment of this kind of @entity2 in the future.

title: [Treatment of XXXX with inversive @entity1 plate combined with steel wire].

answer: @entity6


abstract: OBJECTIVE: To study clinical effects of inversive @entity1 ( @entity1 , @entity1 ) plate combined with steel wire for the treatment of @entity6 . METHODS: From January 2009 to Janurary 2012, 11 @entity0 with @entity6 were treated with inversive @entity1 plate combined with steel wire, including 8 males and 3 females, ranging in age from 35 to 61 years old (averaged, 51 years old). Causes of injury: 8 @entity0 caused by accident and 3 @entity0 caused by falling down. According to X-ray examination, all the @entity0 were @entity6 and were treated with @entity1 plate combined with steel wire. Merle d'Aubigne scores were used to evaluate therapeutic effects on hip. RESULTS: The mean period of follow-up was 16 months (ranged, 12 to 28 months). All the @entity0 obtained bone union for average 3.8 months (ranged from 3 to 4.3 months). There were no complications such as @entity3 , @entity4 , @entity5 and bone nonunion. According to Merle d'Aubigne scores, 7 @entity0 got an excellent result and 4 good. CONCLUSION: Inversive @entity1 plate combined with steel wire for the treatment of @entity6 is satisfactory, Which can provide stable fixation for @entity2 end and provide an ideal internal fixation method for treatment of this kind of @entity2 in the future.

title: [Treatment of @entity6 with inversive XXXX plate combined with steel wire].

answer: @entity1


abstract: @entity3 ( @entity3 ) and @entity4 ( @entity4 ) are the major hyaluronidases acting synergistically to degrade @entity2 ( @entity2 ). In the kidney, @entity2 is distributed heterogeneously. Our goal was to determine the consequences of a lack of either @entity3 or @entity4 (using specific knockout @entity1 ) on renal function and on @entity0 . Experiments were performed in @entity3 (-/-) and @entity4 (-/-) @entity1 and in their wild-type controls. @entity2 concentration was measured in the plasma and kidney tissue and its distribution through the different kidney zones was examined by immunohistochemistry. Relative mRNA expressions of @entity3 , @entity4 and the 3 main @entity2 synthases were evaluated by quantitative RT-PCR. RESULTS: Kidney function was not impaired in the knockout @entity1 but they displayed elevated @entity2 concentrations in the plasma and in the kidney. @entity3 (-/-) @entity1 presented an accumulation of @entity2 inside the proximal tubular cells whereas @entity4 (-/-) @entity1 showed @entity2 accumulation in the interstitial space. In the cortex and in the outer medulla, @entity3 mRNA expression was up-regulated in @entity4 (-/-) @entity1 . From our study we conclude that somatic hyaluronidases are not required for renal function. However, @entity3 is necessary for the breakdown of intracellular @entity2 in the cortex, whereas @entity4 is essential for the degradation of extracellular @entity2 in all kidney regions.

title: @entity3 and @entity4 are required for XXXX .

answer: @entity0


abstract: @entity3 ( @entity3 ) and @entity4 ( @entity4 ) are the major hyaluronidases acting synergistically to degrade @entity2 ( @entity2 ). In the kidney, @entity2 is distributed heterogeneously. Our goal was to determine the consequences of a lack of either @entity3 or @entity4 (using specific knockout @entity1 ) on renal function and on @entity0 . Experiments were performed in @entity3 (-/-) and @entity4 (-/-) @entity1 and in their wild-type controls. @entity2 concentration was measured in the plasma and kidney tissue and its distribution through the different kidney zones was examined by immunohistochemistry. Relative mRNA expressions of @entity3 , @entity4 and the 3 main @entity2 synthases were evaluated by quantitative RT-PCR. RESULTS: Kidney function was not impaired in the knockout @entity1 but they displayed elevated @entity2 concentrations in the plasma and in the kidney. @entity3 (-/-) @entity1 presented an accumulation of @entity2 inside the proximal tubular cells whereas @entity4 (-/-) @entity1 showed @entity2 accumulation in the interstitial space. In the cortex and in the outer medulla, @entity3 mRNA expression was up-regulated in @entity4 (-/-) @entity1 . From our study we conclude that somatic hyaluronidases are not required for renal function. However, @entity3 is necessary for the breakdown of intracellular @entity2 in the cortex, whereas @entity4 is essential for the degradation of extracellular @entity2 in all kidney regions.

title: @entity3 and XXXX are required for @entity0 .

answer: @entity4


abstract: @entity3 ( @entity3 ) and @entity4 ( @entity4 ) are the major hyaluronidases acting synergistically to degrade @entity2 ( @entity2 ). In the kidney, @entity2 is distributed heterogeneously. Our goal was to determine the consequences of a lack of either @entity3 or @entity4 (using specific knockout @entity1 ) on renal function and on @entity0 . Experiments were performed in @entity3 (-/-) and @entity4 (-/-) @entity1 and in their wild-type controls. @entity2 concentration was measured in the plasma and kidney tissue and its distribution through the different kidney zones was examined by immunohistochemistry. Relative mRNA expressions of @entity3 , @entity4 and the 3 main @entity2 synthases were evaluated by quantitative RT-PCR. RESULTS: Kidney function was not impaired in the knockout @entity1 but they displayed elevated @entity2 concentrations in the plasma and in the kidney. @entity3 (-/-) @entity1 presented an accumulation of @entity2 inside the proximal tubular cells whereas @entity4 (-/-) @entity1 showed @entity2 accumulation in the interstitial space. In the cortex and in the outer medulla, @entity3 mRNA expression was up-regulated in @entity4 (-/-) @entity1 . From our study we conclude that somatic hyaluronidases are not required for renal function. However, @entity3 is necessary for the breakdown of intracellular @entity2 in the cortex, whereas @entity4 is essential for the degradation of extracellular @entity2 in all kidney regions.

title: XXXX and @entity4 are required for @entity0 .

answer: @entity3


abstract: BACKGROUND: @entity6 is associated with higher rates of recurrence after surgery for @entity2 . However, the mechanisms responsible are unknown. The aim was to investigate the inflammatory and angiogenic responses in @entity0 undergoing surgery for @entity2 who had @entity7 , and to compare the results with @entity0 without complications. METHODS: Consecutive @entity0 undergoing surgery for @entity2 with curative intent were included. @entity0 who had an @entity6 or @entity8 were included in the @entity4 group and matched with @entity0 who had an uncomplicated postoperative course. @entity5 and @entity1 were measured in serum and peritoneal fluid. RESULTS: Serum concentration of @entity5 was higher in the @entity4 group (n  =  30) compared with the control group (n  =  30) on day 4 ( @entity4 : 42.3 [27.6-1473.2] versus control: 0.6 [0.6-17.1]  pg/ml; p  =  0.008). @entity5 in peritoneal fluid was higher in the @entity4 group at 48  h and day 4 ( @entity4 : 1000.2 [995.4-1574.0] versus control: 90.3 [35.2.6-106.1]  pg/ml; p  =  0.001). Serum @entity1 was higher in the @entity4 group on day 4 ( @entity4 : 1128.6 [427.3-10000.0] versus control: 438.3 [214.1-677.6]  pg/ml; p  =  0.001). Peritoneal @entity1 concentration was higher in the @entity4 group at 48  h and day 4 ( @entity4 : 10000.0 [2563.0-10000.0] versus control: 477.8 [313.5-814.4]  pg/ml; p  =  0.001). Two-year recurrence rate was higher in @entity0 with @entity4 ( @entity4 : 30% versus control: 4%; p  =  0.001). CONCLUSIONS: @entity7 increases @entity5 and @entity1 after surgery for @entity2 . Amplification of @entity3 and angiogenesis might be one of the mechanisms responsible for the higher recurrence rate observed in @entity0 with @entity6 or @entity8 .

title: XXXX and @entity2 recurrence: A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association.

answer: @entity7


abstract: BACKGROUND: @entity6 is associated with higher rates of recurrence after surgery for @entity2 . However, the mechanisms responsible are unknown. The aim was to investigate the inflammatory and angiogenic responses in @entity0 undergoing surgery for @entity2 who had @entity7 , and to compare the results with @entity0 without complications. METHODS: Consecutive @entity0 undergoing surgery for @entity2 with curative intent were included. @entity0 who had an @entity6 or @entity8 were included in the @entity4 group and matched with @entity0 who had an uncomplicated postoperative course. @entity5 and @entity1 were measured in serum and peritoneal fluid. RESULTS: Serum concentration of @entity5 was higher in the @entity4 group (n  =  30) compared with the control group (n  =  30) on day 4 ( @entity4 : 42.3 [27.6-1473.2] versus control: 0.6 [0.6-17.1]  pg/ml; p  =  0.008). @entity5 in peritoneal fluid was higher in the @entity4 group at 48  h and day 4 ( @entity4 : 1000.2 [995.4-1574.0] versus control: 90.3 [35.2.6-106.1]  pg/ml; p  =  0.001). Serum @entity1 was higher in the @entity4 group on day 4 ( @entity4 : 1128.6 [427.3-10000.0] versus control: 438.3 [214.1-677.6]  pg/ml; p  =  0.001). Peritoneal @entity1 concentration was higher in the @entity4 group at 48  h and day 4 ( @entity4 : 10000.0 [2563.0-10000.0] versus control: 477.8 [313.5-814.4]  pg/ml; p  =  0.001). Two-year recurrence rate was higher in @entity0 with @entity4 ( @entity4 : 30% versus control: 4%; p  =  0.001). CONCLUSIONS: @entity7 increases @entity5 and @entity1 after surgery for @entity2 . Amplification of @entity3 and angiogenesis might be one of the mechanisms responsible for the higher recurrence rate observed in @entity0 with @entity6 or @entity8 .

title: @entity7 and XXXX recurrence: A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association.

answer: @entity2


abstract: The present paper's main work is firstly preparing a single layer and a large area @entity1 microspheres mask, with 117, 350 and 500 nm in diameter, and then depositing a layer of @entity2 thin film on the mask board by RF magnetron sputtering technique, using nanospheres lithography technique to remove the @entity1 spheres by soaking with @entity4 , and two-dimensional @entity2 nano-array samples were obtained at last. The samples were characterized on the morphology and composition by scanning electron microscopy and energy dispersive X-ray spectrometer. The results showed that the samples are @entity2 nanocluster formed by ordered cellular reticular structures. By measuring with absorption spectroscopy in the range from 300 to 800 nm at room temperature, the absorption peak turns up with broadening and red shift with the increase in the diameter of @entity1 colloidal spheres, namely the nano-particles diameters. As the sputtering time increases, that is, the increase in the @entity2 film thickness, the light absorption rate increases. In addition, theoretical calculation based on the theory of discrete dipole approximation was performed to simulate the optical absorption properties of the @entity2 nanocluster arrays between 300 and 800 nm. Dipole approximation theory can be used to calculate the absorption of the particles of any shape and size. Currently, the theoretical calculation results of various shapes of nanostructured metals such as gold and @entity0 are consist ent with the experimental results. But the application of the theory of discrete dipole approximation calculation of @entity3 nanoparticles was rarely reported. In this paper, this theory has been used to calculate the optical absorption properties of triangle-shaped @entity3 nanoparticles array. Light absorption characteristics were simulated according to changes in the dielectric constant and thickness of @entity2 films, and the results can be used to explain the experimental results.

title: [Research on the preparation and optical absorption properties of two-dimensional XXXX array].

answer: @entity3


abstract: The clinical and laboratory features of 24 @entity0 with proven @entity10 ( @entity10 ) and @entity3 are reported. The age range of affected @entity0 was between 20 and 63 years (average of 43) and 70 percent were @entity0 . @entity10 was documented prior to the @entity3 in only 4 @entity0 . The majority of @entity0 experienced bland @entity4 . Disorders also included transient @entity1 attacks, @entity8 , parencymatous and @entity6 , @entity5 and @entity7 . Significant risk factors for @entity2 other than @entity10 were lacking in the @entity0 group. Cerebral angiograms occasionally showed distal occlusions of small arteries suggesting @entity3 . Our study suggests that @entity10 is a risk factor for @entity2 . We recommend echocardiography in @entity0 with @entity9 who lack clear, recognized risk factors for @entity2 . We believe the basis for this @entity3 to be emboli from damaged mitral valve leaflets.

title: Brain events associated with XXXX .

answer: @entity10


abstract: BACKGROUND: Traditionally, conservative breast surgery was contraindicated in centrally located @entity0 , with total mastectomy as the treatment of choice. However, restorations of the central defects by the oncoplastic volume displacement or replacement techniques have been shown to be effective. The aim of the current study was to assess the surgical outcome of oncoplastic techniques after central @entity0 resection. METHODS: Thirty @entity1 with central @entity0 , including two @entity1 with @entity4 , treated at the Oncology Center of Mansoura University (Egypt) between June 2011 and December 2014 were included in this study. The oncoplastic techniques performed were Grisotti advancement rotational flap in eight (26.7  %) @entity1 , classic skin-sparing mastectomy (SSM) with latissimus dorsi pedicled flap in 20 (66.7  %) @entity1 , and skin-reducing mastectomy (SRM) with latissimus dorsi pedicled flap using wise pattern inverted T incision in two (6.7  %) @entity1 . The choice of the oncoplastic techniques depends on the achievement of free safety margins, the breast volume, and its ptotic degree. RESULTS: The median age was 40.5  years (range; 23-55). There were no major complications that require repeating the oncoplastic techniques. Recorded complications included wound @entity5 (4/30, 13.3  %) donor site seroma (4/30, 13.3  %), and @entity3 (1/30, 3.3  %). The 6-month subjective @entity1 satisfaction was excellent in 21 (70  %) @entity1 , good in 6 (20  %) @entity1 , and fair in 3 (10  %) @entity1 . There was no episode of local recurrence or systemic @entity2 after an average follow-up duration of 24  months (range; 6-42). CONCLUSIONS: Restoring the central defect after resection of the central @entity0 can be safely achieved using oncoplastic procedures including the Grisotti technique or the design of SSM or SRM with immediate breast reconstruction. In our @entity1 , these procedures yield a satisfactory esthetic outcome with lower morbidity.

title: The outcome of oncoplastic techniques in defect reconstruction after resection of central XXXX .

answer: @entity0


abstract: BACKGROUND: To examine possible associations between midregional proatrial natriuretic peptide (MR-proANP) and @entity1 complications at baseline and risk of mortality and @entity5 ( @entity5 ) during follow-up in type 1 @entity1 . METHODS: Observational study including 667 @entity0 , with plasma MR-proANP measured at baseline. Complications were defined as micro- (n = 168) or macroalbuminuria (n = 190) (urinary albumin excretion rate (UAER) 30-299 or >= 300mg/24h), previous @entity3 ( @entity3 ) (n = 143), cardiac @entity10 (heart rate variability < 11 beats/min) (n = 369), and @entity7 (n = 523). Adjustments included gender, age, systolic blood pressure, estimated glomerular filtration rate (eGFR), UAER, HbA1c, total @entity4 , 24-hour urinary @entity9 excretion (24h-UNa), body mass index, daily insulin dose, antihypertensive treatment, and smoking in linear regression analyses and analysis of covariance models. Development of @entity5 (dialysis, renal transplantation, or GFR/eGFR < 15ml/ @entity8 .73 m(2)) and mortality was recorded through national registers. RESULTS: The cohort included 293 (44%) females, aged 55    13 years. Plasma MR-proANP (median (interquartile)) was 74.7 (49.2-116.8) pmol/L. Adjusted, MR-proANP correlated positively with age and UAER and negatively with eGFR, 24h-UNa, total @entity4 , and HbA1c (P < 0.05). Moreover, MR-proANP levels increased with @entity6 degree and were higher in @entity0 with previous @entity3 (P  <= 0.001), but similar in @entity0 with or without @entity10 or @entity7 (P >=  0.076). During follow-up (3.5 (3.1-4.0) years), higher MR-proANP concentrations predicted @entity5 and mortality combined (n = 35) adjusted for gender, age, systolic blood pressure, eGFR, and previous @entity3 (hazard ratio per 1SD increase in logANP: 2.8 (1.6-4.7; P < 0.001)). CONCLUSIONS: Increased plasma MR-proANP was associated with @entity2 , increased @entity6 , and previous @entity3 . Moreover, MR-proANP concentrations were associated with increased risk of development of @entity5 and mortality combined during follow-up.

title: Increased Plasma Concentrations of Midregional Proatrial Natriuretic Peptide Is Associated With Risk of Cardiorenal Dysfunction in Type 1 XXXX .

answer: @entity1