abstract: @entity2 occurs frequently in @entity0 with @entity3 ( @entity3 ). Although there have been case reports of detection of @entity2 by 2-dimensional echocardiography, no study has examined the frequency of @entity2 detected by cardiac ultrasound in @entity0 with @entity3 . Echocardiography was performed in 16 consecutive @entity0 with @entity3 . Physical examination revealed normal cardiac findings in each. Discrete areas of increased acoustic density were found in 8 of the 16 @entity0 (50%). The maximum diameters ranged from 3 to 20 mm. Multiple areas were found in 3 of 8. The left ventricle was involved in 5 of the 8. Six masses were intracavitary and 8 were intramyocardial. No atrial masses were seen. Left ventricular size and function were normal. Although other @entity1 cannot be excluded, the diagnosis of @entity2 is almost certain in these young @entity0 with @entity3 . The male predominance and the high incidence of intracavitary and left ventricular masses are similar to those in reported autopsy series, also supporting the diagnosis of @entity2 . The prognosis and potential for growth of these masses are not known, but can be determined by longitudinal follow-up. Cardiac ultrasound should be considered for all @entity0 with @entity3 regardless of physical findings.

title: Echocardiographic incidence of XXXX in @entity3 .

answer: @entity2


abstract: This study examined the effect of an orally active @entity2 (TXA2) synthetase inhibitor (TSI) on the patency, TXA2 production, and platelet accumulation of reversed autogenous vein grafts. Ten @entity1 received TSI ( @entity4 ) 10 mg/kg po q8 hr for 6 weeks, beginning 24 hr prior to surgery, while 15 control @entity1 were untreated. One jugular vein was harvested and stored in 37 degrees C saline for 1 hr to induce mild @entity0 (stored). Normal and stored jugular vein grafts (8 cm) were then implanted in opposite femoral arteries while 3-cm segments of the same veins were implanted in the carotid arteries. Femoral graft flow was restricted with a 5 Fr distal arterial stenosis and patency determined by arteriography at 1, 2, 4, and 6 weeks. Vein graft endothelial surface @entity3 production was measured by RIA at graft implantation and in carotid grafts harvested at 1 week. 111In-labeled platelets were given iv 24 hr prior to carotid graft harvest to determine graft-platelet deposition. TSI treatment improved early (1 week) femoral vein graft patency from 63 to 89% (P less than 0.05), a trend that persisted for 6 weeks. Warm saline storage reduced 1-week graft patency from 83 to 63% (P less than 0.05), a difference that decreased with time. TSI treatment resulted in a marked decrease in TXB2 production, but was not associated with decreased 111In-labeled platelet deposition in carotid vein grafts. Warm saline storage increased graft-platelet deposition which was predominant at the arterial anastomoses. TSI treatment may improve early vein graft patency during the transient period of @entity0 .

title: Effect of XXXX synthetase inhibition on @entity1 autogenous vein grafts.

answer: @entity2


abstract: This study examined the effect of an orally active @entity2 (TXA2) synthetase inhibitor (TSI) on the patency, TXA2 production, and platelet accumulation of reversed autogenous vein grafts. Ten @entity1 received TSI ( @entity4 ) 10 mg/kg po q8 hr for 6 weeks, beginning 24 hr prior to surgery, while 15 control @entity1 were untreated. One jugular vein was harvested and stored in 37 degrees C saline for 1 hr to induce mild @entity0 (stored). Normal and stored jugular vein grafts (8 cm) were then implanted in opposite femoral arteries while 3-cm segments of the same veins were implanted in the carotid arteries. Femoral graft flow was restricted with a 5 Fr distal arterial stenosis and patency determined by arteriography at 1, 2, 4, and 6 weeks. Vein graft endothelial surface @entity3 production was measured by RIA at graft implantation and in carotid grafts harvested at 1 week. 111In-labeled platelets were given iv 24 hr prior to carotid graft harvest to determine graft-platelet deposition. TSI treatment improved early (1 week) femoral vein graft patency from 63 to 89% (P less than 0.05), a trend that persisted for 6 weeks. Warm saline storage reduced 1-week graft patency from 83 to 63% (P less than 0.05), a difference that decreased with time. TSI treatment resulted in a marked decrease in TXB2 production, but was not associated with decreased 111In-labeled platelet deposition in carotid vein grafts. Warm saline storage increased graft-platelet deposition which was predominant at the arterial anastomoses. TSI treatment may improve early vein graft patency during the transient period of @entity0 .

title: Effect of @entity2 synthetase inhibition on XXXX autogenous vein grafts.

answer: @entity1


abstract: BACKGROUND: After chemotherapy for nonseminomatous @entity7 (NSTGCT), residual masses or recurrent disease may contain a non-germ cell malignancy (NGCM). METHODS: Over 20 years, 369 @entity0 with disseminated NSTGCT were treated with @entity6 -based polychemotherapy at the University Medical Center Groningen. @entity2 masses were resected in 244 @entity0 and recurrent @entity1 masses in 37 @entity0 . Histology was reviewed, focusing on the presence of NGCM. RESULTS: Nine @entity0 developed an NGCM. Four @entity0 had an NGCM in the resected @entity2 mass after chemotherapy: three @entity0 had a @entity4 , and one @entity0 had both a @entity4 and an @entity5 . Five @entity0 developed a late recurrence with an NGCM after 39, 40, 72, 72, and 84 months. One @entity0 had a primitive @entity8 , one had a @entity4 , and three had an @entity5 in the resected recurrent @entity1 mass. A complete surgical resection was achieved in five (56%) of the nine @entity0 . After a median follow-up of 48 months (range, 3-271 months), five @entity0 had no evidence of disease (56%), three @entity0 were @entity3 (33%), and one @entity0 was alive with disease (11%). CONCLUSIONS: @entity4 , @entity5 , or both in residual or recurrent @entity1 masses after combined-modality NSTGCT treatment are rare. Complete surgical resection of the @entity1 mass is the only curative treatment option.

title: Non-germ cell malignancy in residual or recurrent mass after chemotherapy for nonseminomatous XXXX .

answer: @entity7


abstract: We investigated the possibility that altered cell calcium regulation may affect function of isolated Kyoto spontaneously @entity1 @entity0 (SHR) kidneys as compared with kidneys from @entity0 -Kyoto control (WKY) @entity0 . The kidneys were perfused at 120 and 160 mmHg. At 120 mmHg, SHR glomerular filtration rate (GFR) was 0.24 +/- 0.04 compared with WKY GFR of 0.70 +/- 0.10 ml/min (P = 0.001). At 160 mmHg, SHR GFR was 0.48 +/- 0.05 compared with WKY GFR of 1.09 +/- 0.05 ml/min (P less than 0.001). At 120 mmHg, addition of @entity2 increased renal vascular resistance (RVR) by 50% and decreased SHR GFR by 27% and WKY GFR by 57% (P = 0.04). At 160 mmHg, @entity2 elicited similar changes. Addition of @entity3 , 5-10 microM, in the presence of @entity2 returned RVR to 100-110% of control. With @entity3 at 120 mmHg, SHR GFR increased to 0.84 +/- 0.23 ml/min, a value 3.5 times that of control (P = 0.03). In contrast, WKY GFR in the presence of @entity2 and @entity3 was 0.97 +/- 0.07 ml/min, unchanged from control (P = 0.07). At 160 mmHg, @entity2 and @entity3 also failed to increase WKY GFR above control (P = 0.4) but increased SHR GFR to 52% above control (P = 0.03). Isolated SHR kidneys exhibited exaggerated GFR responses to @entity3 but not to @entity2 . Abnormal cell calcium regulation may underlie the marked decrease in GFR when SHR kidneys are perfused acutely at normotensive perfusion pressures.

title: Glomerular response to XXXX by isolated spontaneously @entity1 @entity0 kidney.

answer: @entity3


abstract: We investigated the possibility that altered cell calcium regulation may affect function of isolated Kyoto spontaneously @entity1 @entity0 (SHR) kidneys as compared with kidneys from @entity0 -Kyoto control (WKY) @entity0 . The kidneys were perfused at 120 and 160 mmHg. At 120 mmHg, SHR glomerular filtration rate (GFR) was 0.24 +/- 0.04 compared with WKY GFR of 0.70 +/- 0.10 ml/min (P = 0.001). At 160 mmHg, SHR GFR was 0.48 +/- 0.05 compared with WKY GFR of 1.09 +/- 0.05 ml/min (P less than 0.001). At 120 mmHg, addition of @entity2 increased renal vascular resistance (RVR) by 50% and decreased SHR GFR by 27% and WKY GFR by 57% (P = 0.04). At 160 mmHg, @entity2 elicited similar changes. Addition of @entity3 , 5-10 microM, in the presence of @entity2 returned RVR to 100-110% of control. With @entity3 at 120 mmHg, SHR GFR increased to 0.84 +/- 0.23 ml/min, a value 3.5 times that of control (P = 0.03). In contrast, WKY GFR in the presence of @entity2 and @entity3 was 0.97 +/- 0.07 ml/min, unchanged from control (P = 0.07). At 160 mmHg, @entity2 and @entity3 also failed to increase WKY GFR above control (P = 0.4) but increased SHR GFR to 52% above control (P = 0.03). Isolated SHR kidneys exhibited exaggerated GFR responses to @entity3 but not to @entity2 . Abnormal cell calcium regulation may underlie the marked decrease in GFR when SHR kidneys are perfused acutely at normotensive perfusion pressures.

title: Glomerular response to @entity3 by isolated spontaneously XXXX @entity0 kidney.

answer: @entity1


abstract: We investigated the possibility that altered cell calcium regulation may affect function of isolated Kyoto spontaneously @entity1 @entity0 (SHR) kidneys as compared with kidneys from @entity0 -Kyoto control (WKY) @entity0 . The kidneys were perfused at 120 and 160 mmHg. At 120 mmHg, SHR glomerular filtration rate (GFR) was 0.24 +/- 0.04 compared with WKY GFR of 0.70 +/- 0.10 ml/min (P = 0.001). At 160 mmHg, SHR GFR was 0.48 +/- 0.05 compared with WKY GFR of 1.09 +/- 0.05 ml/min (P less than 0.001). At 120 mmHg, addition of @entity2 increased renal vascular resistance (RVR) by 50% and decreased SHR GFR by 27% and WKY GFR by 57% (P = 0.04). At 160 mmHg, @entity2 elicited similar changes. Addition of @entity3 , 5-10 microM, in the presence of @entity2 returned RVR to 100-110% of control. With @entity3 at 120 mmHg, SHR GFR increased to 0.84 +/- 0.23 ml/min, a value 3.5 times that of control (P = 0.03). In contrast, WKY GFR in the presence of @entity2 and @entity3 was 0.97 +/- 0.07 ml/min, unchanged from control (P = 0.07). At 160 mmHg, @entity2 and @entity3 also failed to increase WKY GFR above control (P = 0.4) but increased SHR GFR to 52% above control (P = 0.03). Isolated SHR kidneys exhibited exaggerated GFR responses to @entity3 but not to @entity2 . Abnormal cell calcium regulation may underlie the marked decrease in GFR when SHR kidneys are perfused acutely at normotensive perfusion pressures.

title: Glomerular response to @entity3 by isolated spontaneously @entity1 XXXX kidney.

answer: @entity0


abstract: Because of the significant mortality associated with the conventional surgical approach to @entity4 ( @entity4 ) in the high risk @entity0 and in those with @entity5 , we have developed a new approach to this problem, intraluminal @entity1 exclusion. This was achieved by an intraluminal prosthesis which approximated the diameter of the aorta above and below the @entity1 and is inserted through the femoral artery. The prosthesis consisted of biomedical grade elastomeric @entity6 with a NITINOL and/or stainless steel frame and was designed in such a configuration that it could be compressed inside a 15 F catheter and then regain its original shape after being discharged inside the aorta. The @entity6 prosthesis tolerated static pressures in excess of 300 Torr. Aneurysmal aortas were created in three adult @entity3 using large knitted Dacron pathches (6 X 9 cm) sewn onto a longitudinal aortotomy. After 4-6 weeks, an intraluminal prosthesis was passed transfemorally to the location of the @entity2 . Following satisfactory placement and expansion of the prosthesis, a laceration was produced in the aneurysmal wall. No bleeding developed, which confirmed the integrity of the prosthesis in excluding the @entity1 from the aorta proper. Pulsation in the iliac arteries indicated the presence of aortic blood flow through the prosthesis. Autopsy examination demonstrated directly that the prosthesis was open and that its two ends were fixed in the aorta above and below the @entity1 . The study has demonstrated that intraluminal @entity4 exclusion could be achieved with an intraluminal @entity6 prosthesis inserted through the femoral artery.

title: Transfemoral placement of intraluminal @entity6 prosthesis for XXXX .

answer: @entity4


abstract: Because of the significant mortality associated with the conventional surgical approach to @entity4 ( @entity4 ) in the high risk @entity0 and in those with @entity5 , we have developed a new approach to this problem, intraluminal @entity1 exclusion. This was achieved by an intraluminal prosthesis which approximated the diameter of the aorta above and below the @entity1 and is inserted through the femoral artery. The prosthesis consisted of biomedical grade elastomeric @entity6 with a NITINOL and/or stainless steel frame and was designed in such a configuration that it could be compressed inside a 15 F catheter and then regain its original shape after being discharged inside the aorta. The @entity6 prosthesis tolerated static pressures in excess of 300 Torr. Aneurysmal aortas were created in three adult @entity3 using large knitted Dacron pathches (6 X 9 cm) sewn onto a longitudinal aortotomy. After 4-6 weeks, an intraluminal prosthesis was passed transfemorally to the location of the @entity2 . Following satisfactory placement and expansion of the prosthesis, a laceration was produced in the aneurysmal wall. No bleeding developed, which confirmed the integrity of the prosthesis in excluding the @entity1 from the aorta proper. Pulsation in the iliac arteries indicated the presence of aortic blood flow through the prosthesis. Autopsy examination demonstrated directly that the prosthesis was open and that its two ends were fixed in the aorta above and below the @entity1 . The study has demonstrated that intraluminal @entity4 exclusion could be achieved with an intraluminal @entity6 prosthesis inserted through the femoral artery.

title: Transfemoral placement of intraluminal XXXX prosthesis for @entity4 .

answer: @entity6


abstract: @entity3 is a leading cause of @entity4 in countries where consumption of meat and poultry is high. For example, each year in the United States, this organism is the second or third most common cause of confirmed cases of @entity4 . Surveys of the incidence of this organism in retail foods were done in the 1960s without regard to whether isolates were enterotoxigenic. It is now known that not all strains of this organism possess the @entity5 gene responsible for illness. We examined the incidence of this organism in 131 food samples from retail food stores in an area of the northeastern United States. Forty isolates were obtained by using the @entity0 milk method at 45 degrees C, with confirmation by use of motility @entity1 and lactose gelatin media. The presence of the @entity3 @entity5 (cpe) and alpha toxin (cpa) genes was determined by PCR using previously published primer sequences. All isolates possessed cpa. None of the isolates were identified as carrying the cpe gene by this method or by another method using a @entity2 -labeled gene probe. Consistent with these results, none of the sporulating-cell extracts contained @entity5 as determined by reverse passive latex hemagglutination. Pulsed-field gel electrophoresis was used to determine the genetic relatedness of the isolates. About 5% of the isolates were considered to be closely related (2- to 3-band difference). The others were considered to be unrelated to one another. The results demonstrate the rarity of cpe(+) strains in retail foods and the genetic diversity among nonoutbreak strains.

title: Enterotoxigenicity and genetic relatedness of XXXX isolates from retail foods in the United States.

answer: @entity3


abstract: After ejaculation, @entity0 spermatozoa must undergo capacitation to fertilize. Capacitation of @entity1 spermatozoa occurs in vitro in medium supplemented with heparin. Semen cryopreservation is an important tool for assisted reproduction, although the fertility of frozen-thawed spermatozoa is reduced, possibly due to precocious capacitation-like changes that are known to occur. Our purpose was to clarify the mechanisms involved in bull sperm cryocapacitation induced by cryopreservation. Our general hypothesis is that the signaling pathways that lead to capacitation are triggered by the cryopreservation procedure. Ejaculated @entity1 semen was divided into two aliquots and diluted in extender; one was then kept fresh, whereas the second was cryopreserved. Western blots of extracted sperm proteins with anti- @entity5 antibody showed that capacitation, induced by either heparin in fresh sperm or cryopreservation (cryocapacitation), is associated with a differential profile of @entity5 -containing proteins. Immunolocalization of @entity5 -containing proteins in the fresh and cryopreserved spermatozoa showed that, after thawing, cryocapacitated sperm displayed labeling over the acrosomal region, whereas for fresh sperm, this labeling appeared after 5-h incubation with heparin. The @entity4 assay and the ability of the sperm to undergo the @entity3 -induced acrosome reaction were used to confirm that a subpopulation of cryopreserved sperm is capacitated at thawing, irrespective of heparin inclusion. Since @entity2 is known to inhibit heparin-induced capacitation, the semen extender was modified to include @entity2 as a means of inhibiting cryocapacitation; however, cryocapacitation was not prevented according to the @entity4 assay and profile of @entity5 -containing sperm proteins.

title: A differential mechanism is involved during heparin- and cryopreservation-induced capacitation of XXXX spermatozoa.

answer: @entity1


abstract: The course of recovery of heart activity [assessed by heart rate, atrioventricular (AV) conduction time, monophasic action potentials, contractile force, and perfusion rate] from hypothermic @entity1 was studied on isolated perfused @entity0 hearts. The effect of control @entity1 was compared with various cardioplegic protective formulations based on high K+ content. During control hypothermic @entity1 (20 degrees C), the heart activity extinguished only gradually, action potentials were biphasic, AV conduction was extremely prolonged, and contractions were slow and relatively strong. On reperfusion (37 degrees C), the recovery of electrical activity was almost instantaneous and normalized within 2 min, whereas the contractile force remained substantially depressed. In contrast, K+-containing cardioplegic solutions stopped the heart within several cycles. Postarrest recovery was delayed and transitorily associated with severe @entity6 ( @entity5 , repetitive afterdepolarizations and oscillations during elevated plateau, and @entity8 ). Nevertheless, the action potentials as well as the contractile force virtually normalized in 10-15 min. @entity9 -containing cardioplegic solutions were ineffective in preventing the onset of postarrest reperfusion @entity6 , whereas addition of @entity4 to the K+-containing cardioplegic solutions largely prevented these @entity6 , and contractile force was further improved by high concentrations of @entity2 . The data indicate that postarrest electrical and mechanical recovery do not recover in parallel. Furthermore, high concentrations of @entity3 antagonist and @entity2 preserve the electrical and mechanical properties of the cardiac muscle during periods of @entity7 .

title: Differences in electrical and mechanical recovery from XXXX @entity7 and cardioplegia.

answer: @entity1


abstract: The course of recovery of heart activity [assessed by heart rate, atrioventricular (AV) conduction time, monophasic action potentials, contractile force, and perfusion rate] from hypothermic @entity1 was studied on isolated perfused @entity0 hearts. The effect of control @entity1 was compared with various cardioplegic protective formulations based on high K+ content. During control hypothermic @entity1 (20 degrees C), the heart activity extinguished only gradually, action potentials were biphasic, AV conduction was extremely prolonged, and contractions were slow and relatively strong. On reperfusion (37 degrees C), the recovery of electrical activity was almost instantaneous and normalized within 2 min, whereas the contractile force remained substantially depressed. In contrast, K+-containing cardioplegic solutions stopped the heart within several cycles. Postarrest recovery was delayed and transitorily associated with severe @entity6 ( @entity5 , repetitive afterdepolarizations and oscillations during elevated plateau, and @entity8 ). Nevertheless, the action potentials as well as the contractile force virtually normalized in 10-15 min. @entity9 -containing cardioplegic solutions were ineffective in preventing the onset of postarrest reperfusion @entity6 , whereas addition of @entity4 to the K+-containing cardioplegic solutions largely prevented these @entity6 , and contractile force was further improved by high concentrations of @entity2 . The data indicate that postarrest electrical and mechanical recovery do not recover in parallel. Furthermore, high concentrations of @entity3 antagonist and @entity2 preserve the electrical and mechanical properties of the cardiac muscle during periods of @entity7 .

title: Differences in electrical and mechanical recovery from @entity1 XXXX and cardioplegia.

answer: @entity7


abstract: @entity1 has been the antimicrobial of choice for the treatment of @entity3 infections for almost six decades. Although @entity1 -resistant isolates have not been described to date, clinical failures have been reported after treatment with @entity4 . In this study, we analysed the antimicrobial susceptibility and genetic diversity of @entity3 isolates obtained from healthy carriers or @entity0 in different cities in the south and south east of Brazil. The MICs were determined for @entity1 and seven other antimicrobials. @entity1 tolerance was also investigated. Genetic diversity was analysed by PFGE after SmaI fragmentation of the genomic DNA. All 211 isolates tested were susceptible to @entity1 (MIC 0.0025-0.02 mg l(-1)). Four isolates were moderately @entity1 -tolerant (MBC/MIC = 16 mg l(-1)). Most of the other drugs tested were very active against the strains examined, except for @entity2 , to which 50 % of strains were resistant. We also found extensive genetic diversity, in that 60 different patterns were recognized in the 96 strains studied. Indeed, we found no correlation between @entity2 resistance and clonality. Despite this diversity, some PFGE patterns persisted for up to 18 years and specific clone types were spread over different geographical locations

title: Antimicrobial susceptibility patterns and genomic diversity in strains of XXXX isolated in 1978-1997 in different Brazilian cities.

answer: @entity3


abstract: A sex difference in the LH rise after gonadectomy is clearly observable in the @entity0 . While male @entity0 respond with an early (10-12 h) increase in LH after orchidectomy, a delayed response (2-3 days) is recorded after ovariectomy. In this study we tested the hypothesis that the delayed response to gonadectomy in the E2-treated males is due to a more prolonged retention of E2 (when compared with the corresponding male feedback signal, @entity2 ) within specific central nuclear receptor sites. Orchidectomized (ORDX) animals implanted with either empty or E2-filled Silastic capsules were sacrificed at 0, 24, 48 and 72 h after ORDX or E2-capsule removal. LH levels in ORDX @entity0 rose several-fold by 24 h, whereas E2-treated, ORDX @entity0 , showed no changes in peripheral LH levels until 72 h after E2-capsule removal. At the time of E2-capsule removal (0 h) large increases in nuclear @entity1 receptor (NER) levels were seen in anterior pituitary, preoptic area, and @entity4 ( @entity4 ). Twenty-four hours after E2-capsule removal, NER levels were still high in the 3 areas, and by 48 h NER values had returned to control (ORDX) levels, with the exception of @entity4 where they were slightly but significantly elevated. The increase in NER, as well as the subsequent decline after E2-capsule removal was paralleled by similar changes in cytosolic @entity3 receptor (CPR) levels in all three regions. Cytosolic @entity2 levels were not changed by the E2-treatment. The results indicate that the feminized response to orchidectomy observed in E2-implanted males is related to a prolonged retention of the E2-receptor in nuclear sites. Further, they indicate that E2-treatment in males, as is the case in females, can induce a marked increase in progestin receptor levels within specific brain regions as well as in the pituitary. The reduction in NER and CPR levels to castrate values precedes the first detectable increase in peripheral LH levels. In conclusion, the pattern of LH rise after gonadectomy in the @entity0 is dependent upon the steroidal milieu at the time of removal of the gonads.

title: Estrogenic feminization of the LH response to orchidectomy: association with prolonged nuclear XXXX receptor retention and induction of cytoplasmic progestin receptors in brain and pituitary.

answer: @entity1


abstract: As the inclusion criteria for breast conservation therapy have continued to evolve to include @entity3 , very large breasts, and central @entity3 , the potential for significant disfigurement after breast conservation therapy has also increased. This has led some centers to develop coordinated oncology-plastic surgery approaches to ensure both adequate @entity3 resection and aesthetic appearance to the breasts. The authors applied this principle to a specific group of @entity0 @entity1 -- @entity1 with @entity8 --who would benefit from reduction mammaplasty. Eleven @entity1 were identified from the senior author's (S.L.S.) reconstructive practice who underwent breast conservation therapy followed by breast reconfiguration and bilateral reduction mammaplasty. Preoperative brassiere sizes ranged from 34D to 46D. All @entity1 had immediate reduction after frozen sections from the lumpectomy/partial mastectomy margins were determined to be negative. A total of 22 reduction mammaplasties were performed (eight free-nipple grafts, five inferior pedicle flaps, seven superomedial pedicle flaps, and two superolateral flaps) and an average of 1085 g was removed per breast. All @entity1 underwent radiation therapy postoperatively. There were eight minor complications in six @entity1 (one @entity6 , one keloid, one radiation burn, two cases of @entity7 , and three cases of fat @entity4 ). After an average of 24 months' follow-up, there were no local recurrences and one @entity5 from distant @entity2 . Seven of the 11 @entity1 were available and agreed to rate their aesthetic satisfaction on the basis of a scale from 1 to 4, with 4 being the best. The mean satisfaction score was 3.3. Aesthetic outcomes before radiation therapy and after radiation therapy were evaluated by a panel of plastic surgery residents blinded to the purpose of the study. Using a scale of 1 to 4, the aesthetic mean before radiation therapy was 2.9 and the aesthetic mean after radiation therapy was 3.03. By combining breast conservation therapy with breast reconfiguration or reduction in large-breasted @entity1 , multiple benefits are derived. Larger segmental or partial mastectomies can be performed without disfigurement risk, ensuring adequate surgical margins. Immediate reconfiguration of the breast with reduction of the contralateral side creates symmetric, aesthetically pleasing breasts; allows contralateral breast tissue to be evaluated; and spares @entity1 from undergoing a second operative procedure. Such a coordinated program gives @entity1 an important boost, both physically and psychologically, during management of their @entity0 .

title: Experience with reduction mammaplasty combined with breast conservation therapy in the treatment of XXXX .

answer: @entity0


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity4 , @entity5 , and @entity7 on stress and immune responses in @entity0 who underwent modified radical mastectomy. @entity0 : Sixty @entity0 randomly assigned to receive IV @entity4 5 mg (group M, n=20), @entity5 100 mg (group T, n=20), or @entity7 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity3 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity6 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity3 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity1 , @entity2 , and @entity6 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity1 , @entity2 , and @entity6 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity2 , and @entity6 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity1 , and @entity2 decreased in group M compared with group T (P <=0.048) and @entity1 and @entity6 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity4 , @entity5 , and @entity7 suppressed stress and immune responses. @entity7 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous @entity4 , XXXX , and @entity7 on Stress and Immune Responses in @entity0 Undergoing Modified Radical Mastectomy.

answer: @entity5


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity4 , @entity5 , and @entity7 on stress and immune responses in @entity0 who underwent modified radical mastectomy. @entity0 : Sixty @entity0 randomly assigned to receive IV @entity4 5 mg (group M, n=20), @entity5 100 mg (group T, n=20), or @entity7 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity3 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity6 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity3 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity1 , @entity2 , and @entity6 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity1 , @entity2 , and @entity6 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity2 , and @entity6 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity1 , and @entity2 decreased in group M compared with group T (P <=0.048) and @entity1 and @entity6 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity4 , @entity5 , and @entity7 suppressed stress and immune responses. @entity7 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous @entity4 , @entity5 , and XXXX on Stress and Immune Responses in @entity0 Undergoing Modified Radical Mastectomy.

answer: @entity7


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity4 , @entity5 , and @entity7 on stress and immune responses in @entity0 who underwent modified radical mastectomy. @entity0 : Sixty @entity0 randomly assigned to receive IV @entity4 5 mg (group M, n=20), @entity5 100 mg (group T, n=20), or @entity7 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity3 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity6 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity3 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity1 , @entity2 , and @entity6 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity1 , @entity2 , and @entity6 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity2 , and @entity6 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity1 , and @entity2 decreased in group M compared with group T (P <=0.048) and @entity1 and @entity6 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity4 , @entity5 , and @entity7 suppressed stress and immune responses. @entity7 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous XXXX , @entity5 , and @entity7 on Stress and Immune Responses in @entity0 Undergoing Modified Radical Mastectomy.

answer: @entity4


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity4 , @entity5 , and @entity7 on stress and immune responses in @entity0 who underwent modified radical mastectomy. @entity0 : Sixty @entity0 randomly assigned to receive IV @entity4 5 mg (group M, n=20), @entity5 100 mg (group T, n=20), or @entity7 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity3 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity6 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity3 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity1 , @entity2 , and @entity6 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity1 , @entity2 , and @entity6 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity2 , and @entity6 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity1 , and @entity2 decreased in group M compared with group T (P <=0.048) and @entity1 and @entity6 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity4 , @entity5 , and @entity7 suppressed stress and immune responses. @entity7 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous @entity4 , @entity5 , and @entity7 on Stress and Immune Responses in XXXX Undergoing Modified Radical Mastectomy.

answer: @entity0


abstract: OBJECTIVE: To investigate whether @entity4 in M  ni  re's Disease could be diagnosed by comparing vestibular evoked myogenic potential (VEMP) before and after @entity2 administration (F-VEMP). STUDY DESIGN: Retrospective study. SETTING: University hospital. INTERVENTION: @entity2 administration. @entity0 : Twenty-five affected ears of @entity0 with unilateral M  ni  re's Disease were studied. The @entity0 had received confirmed diagnoses M  ni  re's Disease; thus, the presence of @entity4 was suggested. For the control, 22 ears of 11 normal healthy volunteers who had never had vertigo or hearing disturbance were used. MAIN OUTCOME MEASURE: The amplitude of the @entity3 -n23 biphasic wave before and after @entity2 administration. RESULTS: The amplitude of the @entity3 -n23 biphasic wave was significantly enlarged in 7 of 18 cases in which it could be detected before diuretic loading. The biphasic waves appeared after diuretic loading in 3 of 7 cases in which it could not be recorded before loading. Thus, the positive ratio of F-VEMP for unilateral M  ni  re's Disease was considered to be 40% (10 of 25). The ratio was similar to that of the conventional examinations for @entity4 such as the @entity1 test, @entity2 test, and electrocochleogram. CONCLUSION: The F-VEMP test may be useful in the diagnosis of @entity4 .

title: XXXX loading vestibular evoked myogenic potential for unilateral M  ni  re's disease.

answer: @entity2


abstract: @entity3 is a pituitary polypeptide hormone regulating growth in paediatric age as well as inducing anabolic actions directly or @entity1 mediated in adult age. Particularly, in many animals GH and @entity1 receptors were observed in cardiac myocyte membrane. GH modifies left ventricle structure and function. As concerns spontaneous GH secretion, some data suggest that pituitary gland can have a compensatory role on endocrine response to @entity2 . @entity2 stage was directly correlated to nocturnal GH levels. All GH spontaneous night secretion parameters as well as @entity1 levels showed a range between normal @entity0 and very high spontaneous secretion. Therefore in these @entity0 there are either a GH peripheric resistance or a reduction of the activity of GH/ @entity1 axis. Anyhow in our @entity0 , GH 24 hour infusion was inducing a 5 fold increase in GH concentration and a 50% increase in basal @entity1 levels. Anker et al. suggested to evaluate nutritional state in @entity2 @entity0 , observing no differences in non-cachectic @entity0 vs controls, while cachectic @entity0 presented a typical @entity4 . Interestingly, cardiovascular effects of GH administration seem to be only marginally correlated to hemodynamic basal state. On the other hand basal hormonal setting of the @entity0 seems to correlate to the GH-induced cardiovascular response. In fact, low basal @entity1 but high basal GH @entity0 presented the worst endocrine and cardiovascular response to GH infusion. In literature there are controversial data about GH treatment in @entity0 with @entity2 . The heterogeneity of the population could be the reason for this discrepancy. Besides very different @entity1 responses to GH have been reported. Therefore, as there is good clinical evidence that GH acute infusion can improve @entity2 , it seems to be necessary firstly to evaluate the basal endocrine status of the @entity0 . Particularly attention should be given to those @entity0 that present a peripheric GH resistance. On the other hand, those @entity0 with a reduced pituitary GH reserve are supposed to have very beneficial effects from GH treatment.

title: [ @entity3 secretion in XXXX ].

answer: @entity2


abstract: @entity3 is a pituitary polypeptide hormone regulating growth in paediatric age as well as inducing anabolic actions directly or @entity1 mediated in adult age. Particularly, in many animals GH and @entity1 receptors were observed in cardiac myocyte membrane. GH modifies left ventricle structure and function. As concerns spontaneous GH secretion, some data suggest that pituitary gland can have a compensatory role on endocrine response to @entity2 . @entity2 stage was directly correlated to nocturnal GH levels. All GH spontaneous night secretion parameters as well as @entity1 levels showed a range between normal @entity0 and very high spontaneous secretion. Therefore in these @entity0 there are either a GH peripheric resistance or a reduction of the activity of GH/ @entity1 axis. Anyhow in our @entity0 , GH 24 hour infusion was inducing a 5 fold increase in GH concentration and a 50% increase in basal @entity1 levels. Anker et al. suggested to evaluate nutritional state in @entity2 @entity0 , observing no differences in non-cachectic @entity0 vs controls, while cachectic @entity0 presented a typical @entity4 . Interestingly, cardiovascular effects of GH administration seem to be only marginally correlated to hemodynamic basal state. On the other hand basal hormonal setting of the @entity0 seems to correlate to the GH-induced cardiovascular response. In fact, low basal @entity1 but high basal GH @entity0 presented the worst endocrine and cardiovascular response to GH infusion. In literature there are controversial data about GH treatment in @entity0 with @entity2 . The heterogeneity of the population could be the reason for this discrepancy. Besides very different @entity1 responses to GH have been reported. Therefore, as there is good clinical evidence that GH acute infusion can improve @entity2 , it seems to be necessary firstly to evaluate the basal endocrine status of the @entity0 . Particularly attention should be given to those @entity0 that present a peripheric GH resistance. On the other hand, those @entity0 with a reduced pituitary GH reserve are supposed to have very beneficial effects from GH treatment.

title: [ XXXX secretion in @entity2 ].

answer: @entity3


abstract: A discussion of the thermodynamic aspects of a relatively new treatment method for @entity2 of the bone is presented in this paper. The advantages of implanting @entity3 acrylic bone cement into a curetted @entity0 site are briefly discussed and placed in perspective relative to more prevalent surgical treatments. As the bone cement self-heats while curing, the possibility of @entity1 in the bone exists. However, the damage due to heat may be beneficial in reducing the rate of @entity0 recurrence. A thermodynamic consideration of the treatment situation appears to be warranted. After a general introduction and a brief literature review, the theoretical thermodynamic equations are developed. Once the basic equations for the heat transfer from the cement or the bone are derived, there is then a discussion of the various characteristics of bone and @entity3 crucial to the analysis, such as, thermal conductivity, specific heat, density, and heat generation parameters. Finally, in order to reduce the theory to a form which may be used practically, the equations derived are written in terms of finite-difference equations, which approximate them numerically. Different equations are written for each type of @entity4 encountered in the cement-bone system as spacial variances in material and geometry occur. The equations derived may be used to model the system allowing one to predict the time-dependent temperature distribution in bone during the curing of acrylic cement. Using computer techniques to reduce the equations obtained from this analysis, and knowing the temperature at which adjacent cells die, a zone of @entity1 may be mapped surrounding the acrylic impact.

title: Thermodynamic considerations of acrylic cement implant at the site of XXXX of the bone.

answer: @entity2


abstract: @entity1 ( @entity1 ) is relatively common in allogeneic @entity2 ( @entity2 ) recipients. Although lungs are the most common site, central nervous system (CNS) involvement is also observed in this setting. We have retrospectively studied 14 cases of CNS @entity9 found in a cohort of 455 allogeneic @entity2 recipients (incidence 3%). All @entity0 , except one, had experienced @entity7 treated with high-dose @entity6 , and eight @entity0 (57%) had also received ATG. The median time to the diagnosis of CNS @entity9 was 124 days (range 49-347 days) from @entity2 . @entity3 had been diagnosed earlier in four @entity0 (29%). The most common initial symptoms of CNS @entity9 were @entity4 , @entity5 , and mental alteration. Neuroradiological studies revealed single (two @entity0 ) or multiple (seven @entity0 ) focal lesions of 0.2-9 cm in diameter. Despite clinical suspicion in many @entity0 , a confirmed diagnosis of CNS @entity9 was made during life in only one @entity0 . A total of 12 @entity0 (86%) received @entity8 . Despite therapy, all @entity0 died 0-27 days (median seven days) after the initial CNS symptoms. CNS @entity9 is not uncommon in allogeneic @entity2 recipients. Clinical manifestations are usually dramatic and progress quickly. Earlier and more effective treatment of @entity1 is needed to prevent dissemination of infection into the CNS.

title: Central nervous system aspergillosis in allogeneic XXXX recipients.

answer: @entity2


abstract: The role of selective intestinal decontamination with @entity4 (FQ- @entity5 ) in the prevention of early @entity3 (EBIs) in liver transplant recipients (LTRs) is unknown. We used the online database of the Spanish Network of Infection in Transplantation/Spanish Network for Research in @entity1 , which prospectively analyzed 1010 LTRs from 12 Spanish hospitals from September 2003 to February 2005. We compared the incidence and etiology of EBIs (30 days after transplantation) in 415 LTRs from 4 centers that used FQ- @entity5 (>7 days) and in 595 LTRs from 8 hospitals that did not use FQ- @entity5 . A multivariate logistic regression analysis (including an adjustment for the transplant center factor) was performed to evaluate the potential protective factor of FQ- @entity5 in the development of EBIs. We reported 266 EBI episodes in 252 LTRs (incidence = 24.9%). There were no differences in the incidence of EBIs between @entity0 in the FQ- @entity5 group and @entity0 not in the FQ- @entity5 group [109/415 (26.3%) versus 143/595 (24%), P = 0.9]. Although LTRs who received FQ- @entity5 had a lower incidence of @entity2 due to enteric bacteria (2.7% versus 6.5%, P = 0.007) and a higher incidence of @entity2 due to nonfermenting gram-negative bacilli (6.6% versus 2.6%, P = 0.004), these findings could not be confirmed after an adjustment by the center factor in the multivariate models. We found no significant differences in the incidence of @entity2 (3.4% with FQ- @entity5 versus 3.9% without FQ- @entity5 , P = 0.5). Multivariate analysis did not confirm any protective effect of FQ- @entity5 against the development of EBIs by enteric bacteria. In conclusion, FQ- @entity5 does not reduce the incidence of EBIs in LTRs and could be withheld from this group of @entity0 .

title: Selective intestinal decontamination with XXXX for the prevention of early @entity3 after liver transplantation.

answer: @entity4


abstract: The role of selective intestinal decontamination with @entity4 (FQ- @entity5 ) in the prevention of early @entity3 (EBIs) in liver transplant recipients (LTRs) is unknown. We used the online database of the Spanish Network of Infection in Transplantation/Spanish Network for Research in @entity1 , which prospectively analyzed 1010 LTRs from 12 Spanish hospitals from September 2003 to February 2005. We compared the incidence and etiology of EBIs (30 days after transplantation) in 415 LTRs from 4 centers that used FQ- @entity5 (>7 days) and in 595 LTRs from 8 hospitals that did not use FQ- @entity5 . A multivariate logistic regression analysis (including an adjustment for the transplant center factor) was performed to evaluate the potential protective factor of FQ- @entity5 in the development of EBIs. We reported 266 EBI episodes in 252 LTRs (incidence = 24.9%). There were no differences in the incidence of EBIs between @entity0 in the FQ- @entity5 group and @entity0 not in the FQ- @entity5 group [109/415 (26.3%) versus 143/595 (24%), P = 0.9]. Although LTRs who received FQ- @entity5 had a lower incidence of @entity2 due to enteric bacteria (2.7% versus 6.5%, P = 0.007) and a higher incidence of @entity2 due to nonfermenting gram-negative bacilli (6.6% versus 2.6%, P = 0.004), these findings could not be confirmed after an adjustment by the center factor in the multivariate models. We found no significant differences in the incidence of @entity2 (3.4% with FQ- @entity5 versus 3.9% without FQ- @entity5 , P = 0.5). Multivariate analysis did not confirm any protective effect of FQ- @entity5 against the development of EBIs by enteric bacteria. In conclusion, FQ- @entity5 does not reduce the incidence of EBIs in LTRs and could be withheld from this group of @entity0 .

title: Selective intestinal decontamination with @entity4 for the prevention of early XXXX after liver transplantation.

answer: @entity3


abstract: @entity11 is a @entity2 ; it is a rare subtype of @entity10 characterized by the presence of @entity3 cells in the lumina of small vessels. A 49-year-old Caucasian @entity0 was admitted to the Department of Internal Medicine for fatigue, night sweats, loss of weight, and multiple nodules in the forearms. Three months ago the @entity0 's family noticed problems with her cognitive function, she displayed difficulties with common daily tasks. The neurological examination revealed bradypsychia. Laboratory data showed modestly high levels of @entity5 dehydrogenase, and @entity7 . The day after admission, the @entity0 had @entity1 which raised in intensity; his mental status deteriorated, she was disoriented to time and place. She presented @entity8 . The CSF examination revealed a hemorrhagic aspect, elements 30/mm3, cytology: lymphocytes 90%, numerous erythrocytes, proteinorachia 96 mg/dL, glycorrachia 60 mg/dL. Intravenous @entity6 (0.5 g two times a day) and @entity9 20% 1g/kgw/day were administered for five days without response. She became @entity4 and she died six days after hospitalization. The post-mortem macroscopical brain examination showed a swallen brain, with diffuse hemorrhagic areas in the supratentorial subcortical regions. Microscopical examination showed capillaries, venules, and many arterioles distended by large malignant cells suggesting malignant lymphocytes which were intraluminal. Every organ was involved, except for bone marrow and lymph nodes. Immunohistochemical studies showed intensive staining for B cells. and negative staining for factor VIII related antigen, a specific endothelial cell marker. @entity11 was the post-mortem diagnostic. It represents a difficult diagnostic challenge which involves laboratory, imagistic and immunohistochemical investigations.

title: XXXX Presenting as Skin Lesions and Subacute Encephalopathy.

answer: @entity11


abstract: OBJECTIVE: Catalase-peroxidase KatG can protect bacteria from damage of reactive @entity0 species. This study investigated the antioxidative function of catalase - peroxidase gene katG in @entity5 3841. METHODS: katG mutant strain of @entity5 was constructed by homologous recombination. The wild type, katG mutant and @entity4 were challenged by oxidative stress and symbiotic ability. RESULTS: Under free - living conditions, the katG mutant exhibited no generation time extension. However, cells of the katG strain were @entity6 oj high concentrations of @entity3 and were vulnerable after aquick exposure to @entity3 . The real-time qRT-PCR results showec that katG was expressed independently of exogenous @entity3 . In contrast, the katG mutant strain displayed higher expres, level of ohrB gene and lower expression level of grxC than the wild type. With regard to symbiotic capacities with @entity2 , the katG mutant was indistinguishable in root nodule nitrogenase activity and competition nodule ability from the wild type. However, katG gene was expressed significantly lower in bacteroids than that in free-living strains. Besides, the colonization of the @entity2 rhizosphere by the katG mutant was impaired compared to that of the wild type. CONCLUSION: ThE deletion of katG had nosignificant effect in 3841 under the free-living and symbiosis condition but was essential ir antioxidation and colonization of the @entity2 rhizosphere. Although katG could not be induced by @entity3 , it still played acentra role in antioxidation and symbiotic @entity1 fixation by regulating the antioxidant genes such as ohrB and grxC.

title: [Antioxidative function of katG gene in XXXX ].

answer: @entity5


abstract: PURPOSE: To investigate combined immunosuppressive therapy with @entity3 , @entity2 , and prolonged @entity1 in adolescents with refractory @entity5 ( @entity5 ). @entity0 AND METHODS: Ten adolescent @entity0 with @entity5 refractory to previous medical management, including gluco-corticosteroid, intravenous immunoglobulin or anti-Rh (D) IgG, or splenectomy, were treated with combination immunosuppressive therapy at the University of Michigan between 1997 and 2001. Therapy consisted of weekly doses of @entity3 1.5 mg/m intravenous push (IVP) (maximum dose 2 mg), weekly @entity2 100 mg/m IVP, and @entity1 (CSA) 5 mg/kg orally twice daily (goal: CSA trough of 100-200 mg/mL). @entity3 and @entity2 were given weekly until the platelet count was greater than 50,000/mm for a minimum of 2 doses and a maximum of 4 doses. CSA was continued until the platelet count was normal for 3 to 6 months. RESULTS: Seven @entity0 had continuous complete responses (platelet count normal after cessation of CSA), a median of 13 months (9-37 months) since completion of therapy. One @entity0 had a partial response (platelet count 80-120 x 10 /L off CSA for 3 months). Two @entity0 were nonresponders (platelet count <40 x 10 /L), one of whom had all therapy discontinued after 2 weeks due to @entity4 . The median time to response was 7 days (range 7-67 days). CSA was administered for a median of 4 months (range 0.5-19 months). CONCLUSIONS: A combination immunosuppressive approach that includes prolonged @entity1 therapy may be promising for refractory @entity5 and is associated with sustained disease remissions in some @entity0 .

title: Combination therapy for refractory XXXX in adolescents.

answer: @entity5


abstract: OBJECTIVE: To discuss the feasibility, safety and effectiveness of surgical management of post @entity11 ( @entity11 ) @entity8 , mainly focusing on the surgical options and indications. METHODS: This study represented retrospective analysis of 3 kinds of surgical managements of 21 @entity0 with symptomatic @entity11 from April 2012 to April 2014. Patch carotid endarterectomy (pCEA), Eversion carotid endarterectomy (eCEA) or carotid excision and graft interposition (CEGI) was selected to remove the stent and reconstruct the blood flow, based on the preoperative imaging results and intraoperative adhesion degree. Use of carotid shunt, @entity7 , operative time, carotid artery cross-clamp time and other data were recorded. @entity0 were followed for improvement of symptoms, complications and @entity8 . RESULTS: Eleven, 4 and 6 @entity0 received pCEA, eCEA or CEGI respectively. All the stents were successfully removed. Shunts were deployed in 14 cases. The mean bleeding was (152.6    38.0) ml, the mean operation time was (100.7    34.8) min and the mean carotid artery clamping time was (29.1    4.6) min. In the early postoperative period, there were no infection, @entity3 , @entity4 , @entity9 or mortalities. One @entity0 developed @entity5 , while 2 @entity0 had the symptoms of hyperperfusion such as @entity2 , @entity6 and multi-lingual but no @entity10 happened according to the brain CT scan, who all fully recovered within 3 days. Within a median follow-up of (13.2    4.3) months, no @entity3 , @entity9 or recurrent @entity8 (> 50%) on duplex ultrasound imaging or CTA was discovered except for 1 @entity0 who died of @entity1 . CONCLUSION: Surgical management to remove the stent and reconstruct the blood flow, which offered new options in the treatment of @entity11 , with its initially confirmed simplicity, feasibility, safety and validity.

title: [Surgical management of post @entity11 XXXX ].

answer: @entity8


abstract: OBJECTIVE: To discuss the feasibility, safety and effectiveness of surgical management of post @entity11 ( @entity11 ) @entity8 , mainly focusing on the surgical options and indications. METHODS: This study represented retrospective analysis of 3 kinds of surgical managements of 21 @entity0 with symptomatic @entity11 from April 2012 to April 2014. Patch carotid endarterectomy (pCEA), Eversion carotid endarterectomy (eCEA) or carotid excision and graft interposition (CEGI) was selected to remove the stent and reconstruct the blood flow, based on the preoperative imaging results and intraoperative adhesion degree. Use of carotid shunt, @entity7 , operative time, carotid artery cross-clamp time and other data were recorded. @entity0 were followed for improvement of symptoms, complications and @entity8 . RESULTS: Eleven, 4 and 6 @entity0 received pCEA, eCEA or CEGI respectively. All the stents were successfully removed. Shunts were deployed in 14 cases. The mean bleeding was (152.6    38.0) ml, the mean operation time was (100.7    34.8) min and the mean carotid artery clamping time was (29.1    4.6) min. In the early postoperative period, there were no infection, @entity3 , @entity4 , @entity9 or mortalities. One @entity0 developed @entity5 , while 2 @entity0 had the symptoms of hyperperfusion such as @entity2 , @entity6 and multi-lingual but no @entity10 happened according to the brain CT scan, who all fully recovered within 3 days. Within a median follow-up of (13.2    4.3) months, no @entity3 , @entity9 or recurrent @entity8 (> 50%) on duplex ultrasound imaging or CTA was discovered except for 1 @entity0 who died of @entity1 . CONCLUSION: Surgical management to remove the stent and reconstruct the blood flow, which offered new options in the treatment of @entity11 , with its initially confirmed simplicity, feasibility, safety and validity.

title: [Surgical management of post XXXX @entity8 ].

answer: @entity11


abstract: OBJECTIVES: To investigate the effect of some epidemiological and radiologic factors on the outcome of prosthetic replacement in acute proximal humerus @entity2 . DESIGN: Retrospective clinical study. @entity0 : Thirty-two @entity0 [mean age 58 (range 37-83 years)] with a mean follow-up period of 35 months (range 8-80 months). Fifteen cases had Neer type IV, 2 had type III, and 15 @entity0 had @entity2 . MAIN OUTCOME MEASUREMENTS: Neer's criteria, Constant score, and elevation degree were used. Radiological parameters were union and position of the tuberosities, bone stock, and position of the prosthesis. RESULTS: Excellent or good results according to Neer's criteria were obtained in 24 of the 32 cases (75%), and unsatisfactory results in 8 cases (25%). Mean Constant score was 68 (range 19-98) and mean elevation degree 113 (range 30-180). Thirty-one cases (97%) had no or mild @entity1 . Cases operated within 14 days following injury had a better general outcome (p = 0.005). The humeral offset was directly correlated to the elevation degree (p = 0.011) and Constant score (p = 0.002), whereas the head height was inversely correlated to the same parameters (p = 0.001 for both). The cutoff point for the humeral offset-general outcome correlation was calculated as 23 mm using ROC curve analysis. The most common complications were problems concerning the tuberosities (50%), and they adversely affected the clinical outcome (p = 0.002). CONCLUSIONS: Preoperative delay, problems of tuberosity fixation, and position of the tuberosities were parameters influencing the clinical outcome. Lateralization of the tuberosities results in better scores, whereas their distal transfer can be related to a poorer outcome.

title: Prognostic factors in prosthetic replacement for acute proximal humerus XXXX .

answer: @entity2


abstract: It has been suggested that a poor prognosis and the development of @entity4 in @entity0 with @entity7 may be related to @entity6 . We measured the DNA content of bone marrow cells with flow cytometry in 19 hematologically normal subjects and in 70 @entity0 who had recently been diagnosed as having @entity7 . Thirty-four of the @entity0 were found to have @entity5 . This was not related to the percentage of blast cells in the bone marrow, and there was no demarcation in terms of DNA content between @entity0 with a high percentage of blast cells and those with a low percentage of such cells. @entity0 with @entity1 had a significantly shorter survival time than other @entity0 (P = 0.001). @entity0 with @entity3 marrow and those whose marrow had a normal DNA content had similar survival times. Hypodiploidy appears to be a better indicator of poor survival than the marrow blast-cell count. @entity0 with @entity2 invariably had cells with a normal or high DNA content; none of these @entity0 died during the study. Our data suggest that there is a relation between the loss of chromosomal material and progression toward a @entity4 phenotype. It is tempting to speculate that this process may involve a loss of negative regulatory genes ("anti-oncogenes").

title: Prognostic importance of hypodiploid hemopoietic precursors in XXXX .

answer: @entity7


abstract: Massive @entity8 , a nonneoplastic retinal glial proliferation, was first described in detail over 25  years ago, before the era of immunohistochemistry, in a series of 38 cases-to which can be added 30 case reports or small series (no more than 3 cases) subsequently. We analyze a new series of 3 nontumoral intraretinal glioses and 15 cases of @entity10 , not all of which, strictly speaking, were massive. The data from this series are compared with the findings in previously published cases. Included are 2 cases of massive @entity8 diagnosed from evisceration specimens. In reviewing all published and current cases, we were able to establish 3 subgroups of retinal tumoral glioses rather than a single "massive" category: focal nodular @entity9 , @entity9 , and massive @entity9 . Among 43 reported cases, including the present series, but excluding the previous large series of 38 cases in which substantial clinical data were omitted, there were 19 @entity0 and 24 @entity0 . Their mean and median ages were 36.2  years and 36  years, respectively, with a range of 2 to 79  years. All lesions were composed of mitotically quiet, compact spindled fibrous astrocytes devoid of an Alcian blue-positive myxoid matrix. The most common associated ocular conditions were phthisis bulbi and @entity2 or @entity4 . Histopathologically, all 3 tumoral categories were accompanied by progressively more extensive fibrous and osseous metaplasia of the pigment epithelium, the latter forming a clinically and diagnostically useful, almost continuous, outer rim of eggshell @entity5 in the submassive and massive categories that should be detectable with appropriate imaging studies. In decreasing order of frequency, microcysts and macrocysts, @entity3 , exudates, calcospherites, and Rosenthal fibers were observed among the proliferating fibrous astrocytes. Immunohistochemistry was positive for glial fibrillary acidic protein in all cases and nestin in most (an intermediate cytoplasmic filament typically restricted to embryonic and reparative neural tissue). The nonneoplastic nature of all categories of @entity9 was confirmed by absent @entity6 ( @entity1 suppressor gene) dysregulation, Ki-67 negativity, and intact @entity7 expression (the protein product of the @entity7 @entity1 suppressor gene) in the overwhelming majority of cases. These findings indicate an intrinsic attempt to regulate and maintain a low level of glial cell proliferation that becomes unsuccessful as the disease evolves. The categories of tumoral proliferation appeared to constitute a spectrum. We conclude that focal @entity1 encompass lesions previously called retinal vasoproliferative lesions, which display the same histopathologic and immunohistochemical findings as 3 major categories of @entity8 characterized herein.

title: So-called massive XXXX : A critical review and reappraisal.

answer: @entity8


abstract: BACKGROUND: Detachment of the septal leaflet of the tricuspid valve has been described for better access to perimembranous @entity2 . Detachment confined to the anterior leaflet is less known, although it provides a better exposure of the subaortic area and puts less jeopardy on the conduction tissues. METHODS: Data regarding 49 consecutive @entity0 who had congenital perimembranous @entity2 closure were retrospectively reviewed. Thirty-three @entity0 (67%) underwent temporary detachment of the anterior leaflet of the tricuspid valve. The defect was closed with a Gore-Tex patch and a continuous suture. In 10 @entity0 (29%), concomitant right ventricular outflow tract enlargement was performed. Follow-up was obtained in every @entity0 (median time, 11 months; range, 2 to 26 months). RESULTS: No early or late @entity1 occurred. Closure of the @entity2 was complete, with no more than trivial residual jet leaks found in perioperative echocardiography. All @entity0 were in sinus rhythm. The tricuspid valve never showed more than mild insufficiency after repair. No @entity0 showed @entity3 . CONCLUSIONS: Detachment of the anterior leaflet of the tricuspid valve to expose the @entity2 is a safe approach that allows rapid closure of the defect with a continuous suture and provides excellent results.

title: Detachment of the anterior leaflet of the tricuspid valve to expose perimembranous XXXX .

answer: @entity2


abstract: The authors present a case with a @entity9 of the @entity11 and the coexisting @entity3 with the @entity12 , accompanied by @entity7 and @entity10 in the @entity2 . A 44-year-old male, whose past history had been uneventful, was admitted complaining severe @entity1 and @entity4 , followed by @entity8 . CT examinations revealed @entity7 and @entity10 in the @entity2 . Left carotid angiograms disclosed a @entity6 described above. Emergency operation in a state of grade 3 according to Hunt and Kosnik revealed a @entity6 and its parent artery which was thought to be proximally a @entity11 and distally a @entity12 , which was seen to penetrate the anterior cranial fossa at the lamina cribrosa. Then the @entity6 was excised following clipping of the neck. Thereafter, the @entity0 showed favorable recovery. The histological examination revealed absence of the media and the internal elastic lamina in the wall of the @entity6 with slight infiltration of round cells. Generally speaking, distal anterior cerebral @entity5 , which arise on branches beyond the anterior communicating artery, occupy 2-5% of all @entity5 , and most of them are found at the branching site of the pericallosal artery. As far as the authors know, there was few or no report referring to the @entity6 arising on the fronto-orbital artery, as shown in this case. Also, as for the @entity6 arising on the anterior ethmoidal artery, there are a few reports.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A @entity5 and a coexisting XXXX with the anterior ethmoidal artery--a case report].

answer: @entity3


abstract: The authors present a case with a @entity9 of the @entity11 and the coexisting @entity3 with the @entity12 , accompanied by @entity7 and @entity10 in the @entity2 . A 44-year-old male, whose past history had been uneventful, was admitted complaining severe @entity1 and @entity4 , followed by @entity8 . CT examinations revealed @entity7 and @entity10 in the @entity2 . Left carotid angiograms disclosed a @entity6 described above. Emergency operation in a state of grade 3 according to Hunt and Kosnik revealed a @entity6 and its parent artery which was thought to be proximally a @entity11 and distally a @entity12 , which was seen to penetrate the anterior cranial fossa at the lamina cribrosa. Then the @entity6 was excised following clipping of the neck. Thereafter, the @entity0 showed favorable recovery. The histological examination revealed absence of the media and the internal elastic lamina in the wall of the @entity6 with slight infiltration of round cells. Generally speaking, distal anterior cerebral @entity5 , which arise on branches beyond the anterior communicating artery, occupy 2-5% of all @entity5 , and most of them are found at the branching site of the pericallosal artery. As far as the authors know, there was few or no report referring to the @entity6 arising on the fronto-orbital artery, as shown in this case. Also, as for the @entity6 arising on the anterior ethmoidal artery, there are a few reports.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A XXXX and a coexisting @entity3 with the anterior ethmoidal artery--a case report].

answer: @entity5


abstract: Four cases of @entity5 associated with pregnancy are reported. They were a @entity0 anterior communicating @entity1 , a @entity0 of cerebellar hemisphere, a lt-thalamic and @entity6 and @entity5 . As the mode of @entity3 , one case was a @entity2 , one case was a @entity2 combined with a @entity3 and other two cases were @entity3 . The mean age of these 4 cases was 29.5 years of age from 25 to 35. One case was occurred the @entity5 during the first trimester but other 3 cases was occurred during the third trimester. It was, thus, considered the @entity5 associated with pregnancy was more frequently occurred during the third trimester. Primigravida and multigravida were equally occurred on each two cases. It was not related to parity. Consciousness levels were drowsiness; one case, semicoma; two cases and deep @entity4 ; one case. A case of @entity0 anterior communicating @entity1 underwent neck clipping of @entity1 through the rt-fronto-temporal craniotomy on the first day of the attack. This case fully recovered, but the other three cases of severely impaired consciousness level were dead. Maternal prognosis was related to consciousness level. We mentioned the preferred neurosurgical and obstetrical management to the @entity5 associated with pregnancy.

title: [Intracranial XXXX associated with pregnancy--4 case reports and a review of the literature].

answer: @entity3


abstract: The @entity0 was a 52-year-old @entity0 who was initially admitted to our hospital with a recent history of @entity9 , @entity11 and @entity6 on the right, adding to 6 years history of the right orbital @entity5 . She had gradually developed @entity5 and fatigue of the right knee since childhood and had been suffered from multiple subcutaneous @entity1 in the both hands and the right foot from youth onward. On neurological examination, she has had right exphthalmos and 3rd and 6th @entity4 on the right. Skull X-ray and CT scan showed parasellar calcified mass on the right. In chromosome examination, the inversion of the No. 1 chromosome was disclosed by the Q- and C-band dyeing of her leucocytes and skin culture. @entity13 of her @entity7 and @entity3 were diagnosed by X-ray examination and histological specimen, indicating so-called @entity14 . One year and a half later, she was readmitted to our institution, because of progressive @entity6 on the right and left @entity10 . @entity2 was suspected by the clinical course and neuroradiological findings and was confirmed histologically by the second peration. During postoperative course, intratumoral @entity8 had occurred twice and the @entity0 died, and postmortem examination confirmed her clinical affair. This is the case which was clarified @entity1 in the parasellar region, and is the first case verified the @entity12 in @entity14 .

title: [ XXXX with intracranial manifestation and @entity12 --a case report].

answer: @entity14


abstract: The @entity0 was a 52-year-old @entity0 who was initially admitted to our hospital with a recent history of @entity9 , @entity11 and @entity6 on the right, adding to 6 years history of the right orbital @entity5 . She had gradually developed @entity5 and fatigue of the right knee since childhood and had been suffered from multiple subcutaneous @entity1 in the both hands and the right foot from youth onward. On neurological examination, she has had right exphthalmos and 3rd and 6th @entity4 on the right. Skull X-ray and CT scan showed parasellar calcified mass on the right. In chromosome examination, the inversion of the No. 1 chromosome was disclosed by the Q- and C-band dyeing of her leucocytes and skin culture. @entity13 of her @entity7 and @entity3 were diagnosed by X-ray examination and histological specimen, indicating so-called @entity14 . One year and a half later, she was readmitted to our institution, because of progressive @entity6 on the right and left @entity10 . @entity2 was suspected by the clinical course and neuroradiological findings and was confirmed histologically by the second peration. During postoperative course, intratumoral @entity8 had occurred twice and the @entity0 died, and postmortem examination confirmed her clinical affair. This is the case which was clarified @entity1 in the parasellar region, and is the first case verified the @entity12 in @entity14 .

title: [ @entity14 with intracranial manifestation and XXXX --a case report].

answer: @entity12


abstract: OBJECTIVE: To compare the safety and efficacy of procedure for prolapse and @entity5 (PPH) with Milligan-Morgan hemorrhoidectomy (MMH) in the treatment of @entity5 . METHODS: All the randomized controlled trials (RCT) comparing PPH with MMH in the treatment of @entity5 published between January 1998 and January 2015 were retrieved from PubMed, Embase, Cochrane Library, CBM, CNKI, Wangfang, @entity4 databases. Hand search was applied in Chinese Journal of Gastrointestinal Surgery, Chinese Journal of Coloproctology and Journal of Colorectal and Anal Surgery from the library of Chengdu University of Traditional Chinese Medicine. Associated reference documents in enrolled trials were reviewed. The methodological quality of enrolled trials was evaluated according to the Cochrane handbook for systematic reviews of interventions. Meta-analysis was performed using RevMan 5.3 software. RESULT: Sixteen RCTs recruiting 1411 @entity0 were identified. Among them, 702 @entity0 underwent PPH, and other 709 @entity0 MMH. Meta-analysis showed that as compared to MMH, PPH had shorter operating time(WMD=-12.34, 95% CI:-17.87 to -6.80, P=0.000], shorter hospital stay (WMD=-1.48, 95% CI: -1.81 to -1.14, P=0.000) and shorter time to recover normal activity (WMD=-14.11, 95% CI: -24.51 to -3.70, P=0.008). @entity0 in PPH group experienced less @entity2 at postoperative 24 h, postoperative 1 week and the first postoperative bowel movement (all P<0.01). PPH was more ascendant in terms of the requirement for analgesics(P<0.01). PPH group had higher ratio of wound-healing 2 weeks after surgery (RR=0.19, 95% CI: 0.07 to 0.51, P=0.001), lower ratio of @entity1 (RR=0.39, 95% CI: 0.15 to 0.99, P=0.050) and lower ratio of anal @entity3 (RR=0.62, 95% CI: 0.38 to 1.01, P=0.050), but higher ratio of recurrent disease after 1 year (RR=2.54, 95% CI: 1.21 to 5.31, P=0.010). No significant differences in ratios of @entity1 , urinary retention, and postoperative morbidity of complication were found(all P>0.05). Satisfaction degree of @entity0 in PPH group was better than that in MMH group (OR=2.36, 95% CI:1.36 to 4.07, P=0.002). CONCLUSION: Procedure for prolapse and @entity5 offers some short-term benefits over Milligan-Morgan hemorrhoidectomy, but is associated with a higher rate of recurrent disease.

title: [Meta-analysis of randomized controlled trials comparing procedure for prolapse and XXXX with Milligan-Morgan hemorrhoidectomy in the treatment of @entity5 ].

answer: @entity5


abstract: OBJECTIVE: To compare the safety and efficacy of procedure for prolapse and @entity5 (PPH) with Milligan-Morgan hemorrhoidectomy (MMH) in the treatment of @entity5 . METHODS: All the randomized controlled trials (RCT) comparing PPH with MMH in the treatment of @entity5 published between January 1998 and January 2015 were retrieved from PubMed, Embase, Cochrane Library, CBM, CNKI, Wangfang, @entity4 databases. Hand search was applied in Chinese Journal of Gastrointestinal Surgery, Chinese Journal of Coloproctology and Journal of Colorectal and Anal Surgery from the library of Chengdu University of Traditional Chinese Medicine. Associated reference documents in enrolled trials were reviewed. The methodological quality of enrolled trials was evaluated according to the Cochrane handbook for systematic reviews of interventions. Meta-analysis was performed using RevMan 5.3 software. RESULT: Sixteen RCTs recruiting 1411 @entity0 were identified. Among them, 702 @entity0 underwent PPH, and other 709 @entity0 MMH. Meta-analysis showed that as compared to MMH, PPH had shorter operating time(WMD=-12.34, 95% CI:-17.87 to -6.80, P=0.000], shorter hospital stay (WMD=-1.48, 95% CI: -1.81 to -1.14, P=0.000) and shorter time to recover normal activity (WMD=-14.11, 95% CI: -24.51 to -3.70, P=0.008). @entity0 in PPH group experienced less @entity2 at postoperative 24 h, postoperative 1 week and the first postoperative bowel movement (all P<0.01). PPH was more ascendant in terms of the requirement for analgesics(P<0.01). PPH group had higher ratio of wound-healing 2 weeks after surgery (RR=0.19, 95% CI: 0.07 to 0.51, P=0.001), lower ratio of @entity1 (RR=0.39, 95% CI: 0.15 to 0.99, P=0.050) and lower ratio of anal @entity3 (RR=0.62, 95% CI: 0.38 to 1.01, P=0.050), but higher ratio of recurrent disease after 1 year (RR=2.54, 95% CI: 1.21 to 5.31, P=0.010). No significant differences in ratios of @entity1 , urinary retention, and postoperative morbidity of complication were found(all P>0.05). Satisfaction degree of @entity0 in PPH group was better than that in MMH group (OR=2.36, 95% CI:1.36 to 4.07, P=0.002). CONCLUSION: Procedure for prolapse and @entity5 offers some short-term benefits over Milligan-Morgan hemorrhoidectomy, but is associated with a higher rate of recurrent disease.

title: [Meta-analysis of randomized controlled trials comparing procedure for prolapse and @entity5 with Milligan-Morgan hemorrhoidectomy in the treatment of XXXX ].

answer: @entity5


abstract: We report the long-term follow-up of 12 pediatric-aged @entity0 with @entity6 ( @entity6 ). The mean age at the onset of @entity2 was 5 months with a median delay in diagnosis of 2.5 years. Bacille Calmette-Gu  rin @entity9 was the most common presenting @entity2 (6) followed by suppurative @entity9 (4), @entity10 (1), or @entity3 (1). Prophylaxis with @entity4 was recommended to all @entity0 . During the mean follow-up of 10 years (range, 4-23 years) @entity1 was the most prevalent @entity2 (91%) followed by @entity9 (83%), @entity8 (58%), and @entity10 (25%). Seven (58%) @entity0 developed @entity5 due to grossly delayed diagnosis (3) or poor compliance with antimicrobial prophylaxis (4). Five (41%) @entity0 died during the second decade of life of @entity7 (3) or @entity5 (2). Probability of survival into the third decade of life was estimated to be only 19%. We argue that HLA-identical bone marrow transplantation (BMT), if possible, should be attempted at early age because of significant morbidity and mortality in adolescence. BMT also should be considered in @entity0 who suffer severe @entity2 despite antimicrobial prophylaxis or @entity0 with evidence of @entity5 . Possibility of elective BMT from unrelated donors remains to be carefully evaluated.

title: Long-term follow-up and prognosis of XXXX in Yugoslavia: is there a role for early bone marrow transplantation?

answer: @entity6


abstract: @entity4 is a serious obstetrical complication that tends to occur in the second half of pregnancy that complicates six promiles of pregnancies. The term @entity4 is derived from the beginning letters of the English words indicating laboratory changes, which is occurs as a specific illness in pregnancy. There is hemolysis, elevated liver enzymes and a decreased platelet count. It can present itself with @entity3 or without it. The most serious complications are disseminated @entity5 , @entity1 or various organ failures. The pathogenesis at the moment is not completely known. The basic approach to care is delivery at the earliest possible term. @entity4 generally arises in the second or third trimester of pregnancy, but can also occur after delivery. It has typical signs, which can also arise due to other @entity1 , but more frequently in @entity2 , which in pregnancy given the physiological changes in the body of the pregnant @entity0 is also predisposed. In this context, @entity0 with this problem can seek out other physicians than obstetricians. In our case, we wanted to refer to the needs of early diagnosis of this frequently diagnosed illness, since in the case of late diagnosis and a @entity0 not sent to the obstetrical department can lead to a serious life threatening state for the mother and @entity0 .

title: [A delay in the XXXX diagnosis].

answer: @entity4


abstract: We present a case of a 54 years old female @entity0 after anterior wall left ventricular @entity3 in 2005 who underwent coronary artery bypass graft (CABG) surgery requiring cannulation of the right internal jugular vein (IJV). She was admitted to a Department of @entity2 with left @entity7 ( @entity7 ) following 7 day treatment, with hemoptysis, dyspnoea and fevers. Duplex ultrasound (DUS) was used to diagnose flapping @entity4 in the right IJV, severe @entity6 and, in addition, progressing multiple infiltrates on X-ray a few days later. We empirically adjusted the treatment initiated in primary care and observed deterioration of the severe @entity6 during treatment with low molecular weight heparine. We diagnosed @entity6 ( @entity6 ) and, even though this indication was not included in our drug formulary, we initiated treatment with Arixtra (fondaparinux) 2.5 mg s.c. daily. Intensive conservative treatment was associated with significant clinical and laboratory improvement of the condition, significant regression of the IJV @entity4 as well as the finding on X-ray. The final effective antibiotic treatment lasted 20 ( @entity1 + @entity5 ) and 10 (clindamycin) days, respectively. Treatment with Arixtra (fondaparinux) continued in primary care and lasted a total of 65 days until normal thrombocyte levels were achieved, with gradual transition to oral anticoagulation treatment. The @entity0 was discharged to primary care on the 23rd day of hospitalization when she was stabilized, a febrile and her cardiopulmonary functions were compensated. We did not identify any case of treatment of jugular @entity4 and concurrent @entity6 with fondaparin anywhere in the international literature.

title: [A case of a flapping infected XXXX in the internal jugular vein, septic pneumonias and heparin-induced thrombocytopaenia].

answer: @entity4


abstract: OBJECTIVE: Infantile @entity5 are @entity3 associated with a severe @entity2 presenting in the first 2 years of life, and optimal treatment continues to be debated. This study evaluates early and sustained response to initial treatments and addresses both clinical remission and electrographic resolution of @entity4 . Secondarily, it assesses whether response to treatment differs by etiology or developmental status. METHODS: The National @entity4 Consortium established a multicenter, prospective database enrolling @entity0 with new diagnosis of @entity4 . @entity0 were considered responders if there was clinical remission and resolution of @entity4 that was sustained at 3 months after first treatment initiation. Standard treatments of @entity6 ( @entity6 ), oral @entity1 , and @entity7 were considered individually, and all other nonstandard therapies were analyzed collectively. Developmental status and etiology were assessed. We compared response rates by treatment group using chi-square tests and multivariate logistic regression models. RESULTS: Two hundred thirty @entity0 were enrolled from 22 centers. Overall, 46% of @entity0 receiving standard therapy responded, compared to only 9% who responded to nonstandard therapy (p   <   0.001). Fifty-five percent of @entity0 receiving @entity6 as initial treatment responded, compared to 39% for oral @entity1 , 36% for @entity7 , and 9% for other (p   <   0.001). Neither etiology nor development significantly modified the response pattern by treatment group. INTERPRETATION: Response rate varies by treatment choice. Standard therapies should be considered as initial treatment for @entity4 , including those with impaired development or known structural or genetic/metabolic etiology. @entity6 appeared to be more effective than other standard therapies. Ann Neurol 2016.

title: Response to treatment in a prospective national XXXX .

answer: @entity4


abstract: OBJECTIVES: The aims of the study were to examine barriers to @entity1 screening among @entity0 who have experienced intimate partner violence (IPV) and accessed domestic violence shelters, to compare barriers among those up-to-date (UTD) and not UTD on screening, and to evaluate acceptability of @entity2 self-sampling. MATERIALS AND METHODS: This is a cross-sectional survey in which domestic violence shelters in Ohio were identified and @entity0 completed an anonymous survey assessing UTD screening status, barriers related to screening, history of IPV, intention to follow up on abnormal screening, and acceptability of self-sampling. Characteristics of UTD and not UTD @entity0 were compared using Mann-Whitney U tests. RESULTS: A total of 142 @entity0 from 11 shelters completed the survey. Twenty-three percent of @entity0 were not UTD. @entity0 who were not UTD reported more access-related barriers (mean = 2.2 vs 1.8; p = .006). There was no difference in reported IPV-related barriers between @entity0 who were not UTD and those who are UTD (mean = 2.51 in not UTD vs 2.24 in UTD; p = .13). Regarding future screening, of the @entity0 who expressed a preference, more @entity0 not UTD preferred self-sampling than UTD @entity0 (32% vs 14%; p = .05). CONCLUSIONS: In this study, access-related barriers were more commonly reported among @entity0 not UTD with screening. Addressing these barriers at domestic violence shelters may improve screening among not UTD @entity0 . Self-sampling may also be one feasible approach to support screening in this population.

title: Intimate Partner Violence and Barriers to XXXX Screening: A Gynecologic Oncology Fellow Research Network Study.

answer: @entity1


abstract: Substantially less development to the blastocyst stage occurs in vitro than in vivo and this may be due to @entity2 . Although a large proportion of @entity1 oocytes undergo spontaneous nuclear maturation, less is known about requirements for proper cytoplasmic maturation. Commonly, supraphysiological concentrations of FSH and LH are added to maturation media to improve cumulus expansion, fertilization and embryonic development. Therefore, various concentrations of porcine FSH (pFSH) and recombinant @entity0 FSH (rhFSH) were investigated for their effect on @entity1 cumulus expansion in vitro. Expression of @entity4 , LHr and @entity3 mRNAs was determined in cumulus-oocyte complexes to determine whether they would be useful markers of oocyte competence. In serum-free media, only 1000 ng/ml pFSH induced marked cumulus expansion, but the effect of 100 ng/ml pFSH was amplified in the presence of 10% serum. In contrast, cumulus expansion occurred with 1 ng/ml rhFSH in the absence of serum. @entity4 mRNA was highest at 0-6 h of maturation, then abundance decreased. Similarly, @entity3 mRNA expression was highest from 0-6 h but decreased by 24 h of maturation. However, the relative abundance of LHr mRNA did not change from 6-24 h of maturation. Decreased levels of @entity4 , LHr and @entity3 mRNAs were detected in COCs of poorer quality. In conclusion, expansion of @entity1 cumulus occurred at low doses of rhFSH in serum-free media. In summary, @entity4 , LHr and @entity3 mRNA abundance reflects COC quality and @entity4 and @entity3 mRNA expression changes during in vitro maturation; these genes may be useful markers of oocyte developmental competence.

title: Responsiveness of XXXX cumulus-oocyte-complexes (COC) to porcine and recombinant @entity0 FSH, and the effect of COC quality on gonadotropin receptor and Cx43 marker gene mRNAs during maturation in vitro.

answer: @entity1


abstract: Substantially less development to the blastocyst stage occurs in vitro than in vivo and this may be due to @entity2 . Although a large proportion of @entity1 oocytes undergo spontaneous nuclear maturation, less is known about requirements for proper cytoplasmic maturation. Commonly, supraphysiological concentrations of FSH and LH are added to maturation media to improve cumulus expansion, fertilization and embryonic development. Therefore, various concentrations of porcine FSH (pFSH) and recombinant @entity0 FSH (rhFSH) were investigated for their effect on @entity1 cumulus expansion in vitro. Expression of @entity4 , LHr and @entity3 mRNAs was determined in cumulus-oocyte complexes to determine whether they would be useful markers of oocyte competence. In serum-free media, only 1000 ng/ml pFSH induced marked cumulus expansion, but the effect of 100 ng/ml pFSH was amplified in the presence of 10% serum. In contrast, cumulus expansion occurred with 1 ng/ml rhFSH in the absence of serum. @entity4 mRNA was highest at 0-6 h of maturation, then abundance decreased. Similarly, @entity3 mRNA expression was highest from 0-6 h but decreased by 24 h of maturation. However, the relative abundance of LHr mRNA did not change from 6-24 h of maturation. Decreased levels of @entity4 , LHr and @entity3 mRNAs were detected in COCs of poorer quality. In conclusion, expansion of @entity1 cumulus occurred at low doses of rhFSH in serum-free media. In summary, @entity4 , LHr and @entity3 mRNA abundance reflects COC quality and @entity4 and @entity3 mRNA expression changes during in vitro maturation; these genes may be useful markers of oocyte developmental competence.

title: Responsiveness of @entity1 cumulus-oocyte-complexes (COC) to porcine and recombinant XXXX FSH, and the effect of COC quality on gonadotropin receptor and Cx43 marker gene mRNAs during maturation in vitro.

answer: @entity0


abstract: Heme oxygenase (HO) has been primarily regarded as the rate-limiting enzyme in the degradation of @entity5 . However it has recently been proposed that the inducible isoform, @entity6 (EC 1.14.99.3), functions as a stress-responsive antioxidant enzyme, with the capacity to protect against oxidant-mediated @entity4 . This study used an in vitro model of endothelial permeability to determine the effects of the @entity6 -inducing agent hemin on noncytotoxic endothelial injury mediated by acute oxidant stress. Effects of hemin on oxidant-mediated @entity1 in a number of endothelial cell types were also investigated. A 20-min exposure of @entity0 umbilical vein endothelial cell (HUVEC) monolayers to @entity2 resulted in a significant concentration-dependent increase in permeability, which was reversible 48 h later. Pretreatment of monolayers with hemin for 2 h followed by 18 h in complete medium resulted in @entity6 induction and the attenuation of @entity2 -mediated increases in endothelial permeability, and significantly improved the restoration of endothelial barrier function 48 h later. In HUVEC and in the @entity0 microvascular endothelial cell line HMEC-1, hemin treatment as above resulted in protection against @entity1 , but not in @entity3 aortic endothelial cells (BAECs), where such @entity1 was potentiated. This potentiation was inhibited by incubation with the HO inhibitor @entity7 , supporting a role for @entity6 in the potentiation of the cytotoxic response. When the exposure time of BAEC to hemin was extended to 24 h, @entity2 -mediated @entity1 was attenuated. We conclude that hemin treatment is cytoprotective against noncytotoxic endothelial injury in vitro, under conditions that may not offer global protection against cytotoxic @entity4 . This would indicate that @entity6 induction associated with @entity1 in vivo is not always beneficial and therefore that the use of hemin as a therapeutic agent to offset oxidant injury in vascular endothelium should be undertaken with caution.

title: Role of hemin in the modulation of XXXX -mediated endothelial cell injury.

answer: @entity2


abstract: OBJECTIVE: In this randomized prospective study, we evaluated postoperative morbidity after use of the Harmonic Scalpel (HS), an ultrasonic dissector coagulator (Ethicon Endo-Surgery Inc, Cincinnati, @entity4 ), or conventional electrocautery (EC) during tonsillectomy. STUDY DESIGN AND SETTINGS: Pediatric subjects at 2 sites were randomized and underwent tonsillectomy. Intraoperative @entity2 and operation duration were recorded. Postoperative parameters and complications were recorded. RESULTS: One hundred seventeen subjects completed the study. For the HS group, mean operative time was significantly longer (P < 0.001), but intraoperative @entity2 was equivalent (P = 1.000). HS subjects slept soundly on postoperative days 1, 2, 3, and 14 (P = 0.041, 0.013, 0.022, and 0.038, respectively, compared with EC group). Mean @entity3 scores trended lower for HS subjects on postoperative days 2, 3, and 4. CONCLUSION: The use of the HS in pediatric tonsillectomy showed no increase in intraoperative or postoperative @entity2 compared with the use of EC, and HS provided possible clinical advantages over EC in @entity0 comfort. SIGNIFICANCE: Tonsillectomy subjects in the HS group showed a statistically significant ability to sleep soundly, suggesting that the subjects experienced less @entity1 . These data correlate with the observed decrease in @entity1 scores.

title: Harmonic scalpel tonsillectomy in XXXX : a randomized prospective study.

answer: @entity0


abstract: In this study, we analyzed the influence of cell cycle status manipulations of @entity2 cells on Fas-mediated apoptosis using the @entity4 -dependent @entity0 @entity3 cell line AML-193 as a model. @entity4 and long-term treatment with @entity1 ( @entity1 ) or interferon-alpha ( @entity5 ) were used to manipulate the cell cycle status. Control cells were @entity4 deprived, nonproliferating cells. @entity1 or @entity5 treatment did not induce proliferation in control cells, but resulted in recruitment of cells from resting G(0) phase into activated G(1) phase. Using agonistic anti-Fas antibodies (FAS18), we demonstrated that this shift from G(0) to G(1) was accompanied by a 2.5-fold increase in Fas sensitivity. A similar increase in sensitivity to FAS18 could be obtained by induction of proliferation with @entity4 . Quantitative FACS analysis of surviving cells after FAS18-induced apoptosis showed deletion of the G(1) compartment, but complete protection of resting G(0) cells. Cells in S or G(2)/M phase were relatively protected against Fas induction. In conclusion, sensitivity to Fas-mediated apoptosis was restricted to cells in G(1) phase of the cell cycle, and can be increased by treatment of cells with interferons. By this mechanism, interferon treatment may render @entity2 cells more susceptible to lysis by T cells during immunotherapeutic interventions.

title: High susceptibility of @entity0 XXXX cells to Fas-induced apoptosis is restricted to G1 phase of the cell cycle and can be increased by interferon treatment.

answer: @entity2


abstract: In this study, we analyzed the influence of cell cycle status manipulations of @entity2 cells on Fas-mediated apoptosis using the @entity4 -dependent @entity0 @entity3 cell line AML-193 as a model. @entity4 and long-term treatment with @entity1 ( @entity1 ) or interferon-alpha ( @entity5 ) were used to manipulate the cell cycle status. Control cells were @entity4 deprived, nonproliferating cells. @entity1 or @entity5 treatment did not induce proliferation in control cells, but resulted in recruitment of cells from resting G(0) phase into activated G(1) phase. Using agonistic anti-Fas antibodies (FAS18), we demonstrated that this shift from G(0) to G(1) was accompanied by a 2.5-fold increase in Fas sensitivity. A similar increase in sensitivity to FAS18 could be obtained by induction of proliferation with @entity4 . Quantitative FACS analysis of surviving cells after FAS18-induced apoptosis showed deletion of the G(1) compartment, but complete protection of resting G(0) cells. Cells in S or G(2)/M phase were relatively protected against Fas induction. In conclusion, sensitivity to Fas-mediated apoptosis was restricted to cells in G(1) phase of the cell cycle, and can be increased by treatment of cells with interferons. By this mechanism, interferon treatment may render @entity2 cells more susceptible to lysis by T cells during immunotherapeutic interventions.

title: High susceptibility of XXXX @entity2 cells to Fas-induced apoptosis is restricted to G1 phase of the cell cycle and can be increased by interferon treatment.

answer: @entity0


abstract: The chromosomal translocation t(8;14)(q24;q32) represents a characteristic marker for @entity4 ( @entity4 ). This translocation involves the MYC oncogene on chromosome 8 and the @entity5 ( @entity5 ) locus on chromosome 14. Since the translocation does not produce a fusion gene, we established a long-distance polymerase chain reaction (LD-PCR) assay that can detect the t(8;14) at the genomic level. The sensitivity of the LD-PCR was 10(-4). We used the LD-PCR assay to prospectively study 78 @entity4 @entity0 and found a specific PCR product in 52 of them. Among the 52 positive @entity0 , we could test both the @entity1 and the bone marrow (BM) at diagnosis in 33 and determined the prevalence of @entity3 ( @entity3 ) at diagnosis. In 12/33 @entity0 , BM was positive by LD-PCR and in 10 of them we conducted a study of @entity2 ( @entity2 ). Eight out of 10 @entity0 showed a clearance of @entity2 after one cycle of chemotherapy. The only two @entity0 who did not achieve a negative @entity2 status died of disease progression. The comparative analysis of sensitivity of BM aspirate, BM biopsy and LD-PCR in t(8;14)-positive @entity0 demonstrated a superiority of the molecular method in the assessment of @entity3 . The LD-PCR for t(8;14) is an important tool to study minimal BM infiltration at diagnosis and to determine its response kinetics in @entity4 .

title: Prospective analysis of minimal bone marrow infiltration in pediatric XXXX by long-distance polymerase chain reaction for t(8;14)(q24;q32).

answer: @entity4