abstract: Goal pursuit is known to be impaired in @entity3 , but nothing much is known in these @entity0 about unconscious affective processes underlying goal pursuit. Evidence suggests that in healthy individuals positive subliminal cues are taken as a signal that goal pursuit is easy and therefore reduce the effort that is mobilized for goal attainment. @entity0 with @entity3 and healthy controls were instructed that a long run of successive correct responses in a visual attention task would entitle them to a reward (the goal to attain). Affective pictures were displayed supraliminally or subliminally during each run and electrophysiological activity was recorded. @entity0 self-assessed the emotional content of the pictures correctly. However, differences between @entity0 and controls emerged during the goal pursuit task. Healthy controls mobilized less effort for the positive than the neutral subliminal pictures, as suggested by @entity2 and the weaker contingent negative variation ( @entity4 ). For the @entity0 , no influence of positive subliminal pictures was found on performance and on the @entity4 . Similarly the influence of positive pictures was absent or abnormal on components which are usually impaired in @entity0 (fronto-central P2 and N2). In contrast, positive pictures influenced normally the parieto-occipital N2, related to a component of visual attention which has been proposed to be preserved in @entity3 . The present study indicates the difficulties of @entity0 to modulate effort mobilization during goal pursuit in the presence of positive subliminal cues. The results question the role of @entity1 on affective influences.

title: Influence of positive subliminal and supraliminal affective cues on goal pursuit in XXXX .

answer: @entity3


abstract: OBJECTIVE: To investigate whether guided deep breathing using a device improves breathlessness, quality of life, and breathing pattern in moderate and severe stage of @entity1 ( @entity1 ). METHODS: In total, 150 @entity0 participated in a double-blind randomized controlled trial in a four-week intervention and a four-month follow-up. @entity0 were randomized into a guided deep breathing group (GDBG), music listening group (MLG), or sitting still group (SSG). The @entity0 ' symptom score using the St George's Respiratory Questionnaire (SGRQ), and a Global Rating Change scale (GRC) was applied to measure breathlessness as primary outcome. The activity score and impact score of SRGQ, and breathing pattern were secondary outcomes. RESULTS: Positive effects of the GDBG were detected in GRC scale in breathlessness at four weeks (p=0.03) with remaining effect compared to MLG (p=0.04), but not to SSG at four months follow-up. GDBG showed positive effect for respiratory rate (p<0.001) at four weeks follow-up. A positive significant change (p<0.05-0.01) was found in all groups of SGRQ symptom score. CONCLUSION: GDBG had a beneficial effect on respiratory pattern and breathlessness. MLG and SSG also yielded significant improvements. PRACTICE IMPLICATIONS: Guided deep breathing may be used as a self-management procedure.

title: Effects of guided deep breathing on breathlessness and the breathing pattern in XXXX : A double-blind randomized control study.

answer: @entity1


abstract: BACKGROUND: @entity4 is the commonest arthropod-borne @entity2 worldwide. In recent years, rapid growth in global air travel has resulted in a considerable increase in the incidence of imported cases. In Romania it is now the second most frequent cause for hospitalization (after @entity3 ) in @entity0 arriving from tropical regions. METHODS: Serological and molecular diagnostics were applied to samples obtained between 2008 and 2013 from travelers with suspected dengue. Molecular typing was performed by RT-PCR followed by sequencing of the E-NS1 junction. RESULTS: Twelve of 37 suspected cases were confirmed and three remained probable. The @entity2 were acquired in endemic regions in Asia, Africa and in Europe (Madeira Island). Dengue virus nucleic acid was detected and sequenced in nine cases. Phylogenetic analysis indicated that the viruses were of genotypes I and V of serotype 1, cosmopolitan genotype of serotype 2 and genotypes I and III of serotype 3. CONCLUSIONS: Romanian tourists traveling to dengue-endemic countries are at risk of acquiring @entity2 . Appropriate prevention measures prior to travel and upon return should be taken, particularly as the dengue secondary vector @entity1 is now established in Bucharest.

title: Molecular epidemiology of XXXX imported into Romania between 2008 and 2013.

answer: @entity4


abstract: In response to @entity2 stress, cells of the inner medullary collecting duct (IMCD) undergo swelling followed by a regulatory volume decrease (RVD) and a transient release of organic osmolytes such as @entity5 . In this study, we tested the hypothesis whether membrane recycling is involved in the latter process. Therefore, the state of submembranal actin and the cellular uptake or release of the fluid-phase marker @entity3 ( @entity4 )-dextran ( @entity6 ) were investigated as related to changes in membrane permeability for @entity5 . After exposure to @entity2 medium the submembranal actin web rapidly disaggregated but it started to reorganize after 5 min of incubation. The basal-lateral pole of IMCD cells showed a significant uptake of extracellular @entity6 after 100 sec. After 5 min, part of this fluorescence intensity had moved towards the cell center but the main part remained submembranal. Disintegration of the actin network by cytochalasin D diminished the uptake of @entity6 during @entity2 as did a permanent increase in intracellular @entity0 induced by @entity1 treatment. During a second osmotic stimulation of IMCD cells preloaded with @entity6 , @entity6 was released in a linear time course reaching a plateau after 1 min. Isotonic @entity1 treatment of preloaded cells also generated a rapid @entity6 release during the first minute but induced a further 2-fold increase during the next 4 min. Under both conditions initial @entity6 release was highly correlated with the simultaneously determined increase in @entity5 permeability. A similar strong correlation was found when different incubation temperatures were used (0 degree C, 15 degrees C, 37 degrees C). These results suggest that during exposure of IMCD cells to @entity2 the submembranal actin web rapidly disintegrates, and "reserve" vesicles, probably containing @entity5 transporter, move to and fuse with the basal-lateral plasma membrane. The fusion causes a rapid increase in @entity5 permeability. These membrane areas are recovered by internalization, and the transport systems for @entity5 are concomitantly retrieved. In parallel to this internalization the submembranal actin filament network is rearranged. This process seems to be regulated by changes in intracellular @entity0 .

title: Membrane traffic and XXXX release during osmo- and volume regulation in isolated rat renal inner medullary collecting duct cells.

answer: @entity5


abstract: The aim of the current study was to compare total paracentesis associated with dextran-40 infusion with diuretics in the treatment of tense @entity3 in @entity0 with @entity1 . Eighty @entity0 were randomly allocated to two groups: 40 @entity0 were treated with paracentesis plus dextran-40 infusion (8 g per liter of ascitic fluid removed), and 40 @entity0 with diuretics. After treatment @entity0 were discharged with diuretics, and @entity0 developing tense @entity3 during follow up (54 +/- 4 weeks) were treated according to their initial schedule. Paracentesis was more effective than diuretics in mobilizing the ascitic fluid. The incidence of complications was significantly higher (p < 0.05) in the diuretic group (38%) than in the paracentesis group (15%). This difference was mainly due to a higher incidence of @entity2 in the former group (30% vs. 2.5%). A significantly higher incidence of @entity2 was also observed in the diuretic group during the follow-up readmissions for @entity3 recurrence. There were no significant differences between the two treatment groups in the probability of survival after inclusion. Plasma @entity4 activity and plasma @entity5 concentration measured before and 2 and 6 days after paracentesis in 20 randomly selected @entity0 increased significantly (p < 0.05) (baseline values: 5.3 +/- 1.4 ng.ml-1.h-1 and 63 +/- 21 ng/dl; 48 h after paracentesis: 11.7 +/- 3.9 ng.ml-1.h-1 and 99 +/- 31 ng/dl; 6 days after paracentesis: 10.9 +/- 3 ng.ml-1.h-1 and 110 +/- 27 ng/dl).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Total paracentesis with dextran 40 vs diuretics in the treatment of XXXX in @entity1 : a randomized controlled study.

answer: @entity3


abstract: The aim of the current study was to compare total paracentesis associated with dextran-40 infusion with diuretics in the treatment of tense @entity3 in @entity0 with @entity1 . Eighty @entity0 were randomly allocated to two groups: 40 @entity0 were treated with paracentesis plus dextran-40 infusion (8 g per liter of ascitic fluid removed), and 40 @entity0 with diuretics. After treatment @entity0 were discharged with diuretics, and @entity0 developing tense @entity3 during follow up (54 +/- 4 weeks) were treated according to their initial schedule. Paracentesis was more effective than diuretics in mobilizing the ascitic fluid. The incidence of complications was significantly higher (p < 0.05) in the diuretic group (38%) than in the paracentesis group (15%). This difference was mainly due to a higher incidence of @entity2 in the former group (30% vs. 2.5%). A significantly higher incidence of @entity2 was also observed in the diuretic group during the follow-up readmissions for @entity3 recurrence. There were no significant differences between the two treatment groups in the probability of survival after inclusion. Plasma @entity4 activity and plasma @entity5 concentration measured before and 2 and 6 days after paracentesis in 20 randomly selected @entity0 increased significantly (p < 0.05) (baseline values: 5.3 +/- 1.4 ng.ml-1.h-1 and 63 +/- 21 ng/dl; 48 h after paracentesis: 11.7 +/- 3.9 ng.ml-1.h-1 and 99 +/- 31 ng/dl; 6 days after paracentesis: 10.9 +/- 3 ng.ml-1.h-1 and 110 +/- 27 ng/dl).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Total paracentesis with dextran 40 vs diuretics in the treatment of @entity3 in XXXX : a randomized controlled study.

answer: @entity1


abstract: OBJECTIVES AND METHODS: @entity2 are rare genital @entity1 . In a retrospective study on 21 @entity0 factors influencing the quality of life and sexual function were investigated. All @entity0 were interviewed according to the Female Sexual Function Index questionnaire (FSFI) and the Short Form 12(  ) questionnaire (SF12). RESULTS: We identified 21 @entity0 that had been operated for @entity2 FIGO stage I or IIIa in the years 2006-2008. @entity0 that had  adjuvant radiotherapy were excluded. 14 @entity0 had been treated by a wide excision, the other 7 by a vulvectomy. 10 @entity0 had undergone a total inguinal lymphadenectomy, 5 @entity0 a sentinel node biopsy. In a multivariate analysis lymphadenectomy was the only factor influencing the @entity0 ' sexual function: @entity0 without lymphadenectomy or with sentinel node biopsy scored better in terms of sexual function, neither age nor the extend of the surgery resulted in a significant difference. CONCLUSION: The lymphadenectomy has a negative influence on the @entity0 ' sexual function after surgical treatment for @entity2 . The indication for lymphadenectomy should hence be seen critically.

title: Quality of life and sexual function after surgery in early stage XXXX .

answer: @entity1


abstract: Radiofrequency ablation of accessory pathways must sometimes be done during orthodromic @entity2 when manifest anterograde accessory pathway conduction is absent or retrograde fusion obscures accessory pathway location during ventricular pacing. Unfortunately, abrupt heart rate slowing upon radiofrequency induced termination of @entity2 often causes catheter dislodgment. We report our experience in circumventing this problem during radiofrequency ablation by using entrainment of @entity2 . The latter maintains retrograde activation pattern over the accessory pathway while preventing abrupt ventricular rate change. Eight @entity0 (4 @entity0 and 4 @entity0 , mean age 37.3 +/- 17.9) with eleven left-sided accessory pathways were included. Ablation during entrainment was used as the first approach in three @entity0 with concealed accessory pathways and one @entity0 with a bidirectional accessory pathway. In another four @entity0 , ablation during entrainment was used after technical difficulties in ablating during @entity1 . Only 1-3 radiofrequency applications were required to eliminate the accessory pathway using the entrainment technique. The catheter remained stable when accessory pathway conduction was interrupted by radiofrequency current. In conclusion, entrainment of @entity2 during radiofrequency application is useful for maintaining catheter position for accessory pathway ablation during @entity2 .

title: Radiofrequency catheter ablation of accessory pathways during entrainment of AV reentrant XXXX .

answer: @entity1


abstract: BACKGROUND _ OBJECTIVES: @entity1 ( @entity1 ) is considered to be a protective factor against development of @entity3 . But @entity4 ( @entity4 ) are likely to increase the risk of @entity3 . This study was carried out to evaluate the effect of various @entity4 on @entity2 ( @entity2 ) in @entity0 with @entity1 . METHODS: Forty one @entity0 (study group) with @entity1 (mean age 51.9  5.5 yr; 31 females) receiving treatment with @entity4 ( @entity4 ) [ @entity6 alone (n=14) or in combination with other @entity4 (n=27)] for a period of at least three consecutive years and 41 age- and gender-matched healthy controls (mean age 51.4  5.1 yr) were included in the study. A detailed clinical history was taken and all were subjected to physical examination and recording of anthropometric data. @entity2 was assessed for both @entity0 and controls. RESULTS: The mean body mass index (kg/m [2] ) (26.5  4.90 vs 27.3   5.33) and median [inter-quartile range (IQR)] duration of menopause (yr) among @entity0 [6(2-12) vs 6(1-13)] were comparable between both groups. The @entity2 ( @entity2 ; g/cm [2] ) at the level of neck of femur (NOF) (0.761  0.112 vs 0.762  0.110), lumbar spine antero-posterior view (LSAP) (0.849  0.127 vs 0.854  0.135); median Z-score NOF {0.100[(-0.850)-(0.550)] vs -0.200[(-0.800)-(0.600)]}, LSAP {-1.200[(-1.700)-(-0.200)] vs -1.300 [(-1.85)-(-0.400)]} were also similar in study and control groups. Presence of normal @entity2 (9/41 vs 8/41), @entity5 (16/41 vs 18/41) and @entity3 (16/41 vs 15/41) were comparable between the study and control groups. No significant difference was observed in the @entity2 , T-scores and Z-scores at NOF and LSAP among @entity1 @entity0 treated with @entity6 ; those treated with other @entity4 and controls. INTERPRETATION _ CONCLUSIONS: The present findings show that the use of @entity4 for a period of three years or more does not significantly affect the @entity2 in @entity0 with @entity1 .

title: Effect of @entity4 on bone metabolism in @entity0 with @entity1 _ occurrence of XXXX .

answer: @entity3


abstract: BACKGROUND _ OBJECTIVES: @entity1 ( @entity1 ) is considered to be a protective factor against development of @entity3 . But @entity4 ( @entity4 ) are likely to increase the risk of @entity3 . This study was carried out to evaluate the effect of various @entity4 on @entity2 ( @entity2 ) in @entity0 with @entity1 . METHODS: Forty one @entity0 (study group) with @entity1 (mean age 51.9  5.5 yr; 31 females) receiving treatment with @entity4 ( @entity4 ) [ @entity6 alone (n=14) or in combination with other @entity4 (n=27)] for a period of at least three consecutive years and 41 age- and gender-matched healthy controls (mean age 51.4  5.1 yr) were included in the study. A detailed clinical history was taken and all were subjected to physical examination and recording of anthropometric data. @entity2 was assessed for both @entity0 and controls. RESULTS: The mean body mass index (kg/m [2] ) (26.5  4.90 vs 27.3   5.33) and median [inter-quartile range (IQR)] duration of menopause (yr) among @entity0 [6(2-12) vs 6(1-13)] were comparable between both groups. The @entity2 ( @entity2 ; g/cm [2] ) at the level of neck of femur (NOF) (0.761  0.112 vs 0.762  0.110), lumbar spine antero-posterior view (LSAP) (0.849  0.127 vs 0.854  0.135); median Z-score NOF {0.100[(-0.850)-(0.550)] vs -0.200[(-0.800)-(0.600)]}, LSAP {-1.200[(-1.700)-(-0.200)] vs -1.300 [(-1.85)-(-0.400)]} were also similar in study and control groups. Presence of normal @entity2 (9/41 vs 8/41), @entity5 (16/41 vs 18/41) and @entity3 (16/41 vs 15/41) were comparable between the study and control groups. No significant difference was observed in the @entity2 , T-scores and Z-scores at NOF and LSAP among @entity1 @entity0 treated with @entity6 ; those treated with other @entity4 and controls. INTERPRETATION _ CONCLUSIONS: The present findings show that the use of @entity4 for a period of three years or more does not significantly affect the @entity2 in @entity0 with @entity1 .

title: Effect of XXXX on bone metabolism in @entity0 with @entity1 _ occurrence of @entity3 .

answer: @entity4


abstract: BACKGROUND _ OBJECTIVES: @entity1 ( @entity1 ) is considered to be a protective factor against development of @entity3 . But @entity4 ( @entity4 ) are likely to increase the risk of @entity3 . This study was carried out to evaluate the effect of various @entity4 on @entity2 ( @entity2 ) in @entity0 with @entity1 . METHODS: Forty one @entity0 (study group) with @entity1 (mean age 51.9  5.5 yr; 31 females) receiving treatment with @entity4 ( @entity4 ) [ @entity6 alone (n=14) or in combination with other @entity4 (n=27)] for a period of at least three consecutive years and 41 age- and gender-matched healthy controls (mean age 51.4  5.1 yr) were included in the study. A detailed clinical history was taken and all were subjected to physical examination and recording of anthropometric data. @entity2 was assessed for both @entity0 and controls. RESULTS: The mean body mass index (kg/m [2] ) (26.5  4.90 vs 27.3   5.33) and median [inter-quartile range (IQR)] duration of menopause (yr) among @entity0 [6(2-12) vs 6(1-13)] were comparable between both groups. The @entity2 ( @entity2 ; g/cm [2] ) at the level of neck of femur (NOF) (0.761  0.112 vs 0.762  0.110), lumbar spine antero-posterior view (LSAP) (0.849  0.127 vs 0.854  0.135); median Z-score NOF {0.100[(-0.850)-(0.550)] vs -0.200[(-0.800)-(0.600)]}, LSAP {-1.200[(-1.700)-(-0.200)] vs -1.300 [(-1.85)-(-0.400)]} were also similar in study and control groups. Presence of normal @entity2 (9/41 vs 8/41), @entity5 (16/41 vs 18/41) and @entity3 (16/41 vs 15/41) were comparable between the study and control groups. No significant difference was observed in the @entity2 , T-scores and Z-scores at NOF and LSAP among @entity1 @entity0 treated with @entity6 ; those treated with other @entity4 and controls. INTERPRETATION _ CONCLUSIONS: The present findings show that the use of @entity4 for a period of three years or more does not significantly affect the @entity2 in @entity0 with @entity1 .

title: Effect of @entity4 on bone metabolism in @entity0 with XXXX _ occurrence of @entity3 .

answer: @entity1


abstract: BACKGROUND _ OBJECTIVES: @entity1 ( @entity1 ) is considered to be a protective factor against development of @entity3 . But @entity4 ( @entity4 ) are likely to increase the risk of @entity3 . This study was carried out to evaluate the effect of various @entity4 on @entity2 ( @entity2 ) in @entity0 with @entity1 . METHODS: Forty one @entity0 (study group) with @entity1 (mean age 51.9  5.5 yr; 31 females) receiving treatment with @entity4 ( @entity4 ) [ @entity6 alone (n=14) or in combination with other @entity4 (n=27)] for a period of at least three consecutive years and 41 age- and gender-matched healthy controls (mean age 51.4  5.1 yr) were included in the study. A detailed clinical history was taken and all were subjected to physical examination and recording of anthropometric data. @entity2 was assessed for both @entity0 and controls. RESULTS: The mean body mass index (kg/m [2] ) (26.5  4.90 vs 27.3   5.33) and median [inter-quartile range (IQR)] duration of menopause (yr) among @entity0 [6(2-12) vs 6(1-13)] were comparable between both groups. The @entity2 ( @entity2 ; g/cm [2] ) at the level of neck of femur (NOF) (0.761  0.112 vs 0.762  0.110), lumbar spine antero-posterior view (LSAP) (0.849  0.127 vs 0.854  0.135); median Z-score NOF {0.100[(-0.850)-(0.550)] vs -0.200[(-0.800)-(0.600)]}, LSAP {-1.200[(-1.700)-(-0.200)] vs -1.300 [(-1.85)-(-0.400)]} were also similar in study and control groups. Presence of normal @entity2 (9/41 vs 8/41), @entity5 (16/41 vs 18/41) and @entity3 (16/41 vs 15/41) were comparable between the study and control groups. No significant difference was observed in the @entity2 , T-scores and Z-scores at NOF and LSAP among @entity1 @entity0 treated with @entity6 ; those treated with other @entity4 and controls. INTERPRETATION _ CONCLUSIONS: The present findings show that the use of @entity4 for a period of three years or more does not significantly affect the @entity2 in @entity0 with @entity1 .

title: Effect of @entity4 on bone metabolism in XXXX with @entity1 _ occurrence of @entity3 .

answer: @entity0


abstract: Background Difficult @entity4 Ventilation ( @entity3 ), is a situation in which it is impossible for an unassisted anesthesiologist to maintain @entity1 saturation >90% using 100% @entity1 and positive pressure ventilation to prevent or reverse signs of inadequate ventilation during @entity4 ventilation.   The incidence varies from 0.08 - 15%. @entity0 -related anatomical features are by far the most significant cause.   We analyzed data from an @entity2 surgical population (BMI> 30 kg/m (2)) to identify specific risk and predictive factors for @entity3 . Methods Five hundred and fifty seven @entity2 @entity0 were identified from a database of 1399 cases associated with preoperative airway examinations where @entity4 ventilation was attempted. Assessment of @entity4 ventilation in this group was stratified by a severity score (0-3), and a step-wise selection method was used to identify independent predictors.   The area under the curve of the receiver-operating-characteristic was then used to evaluate the model's predictive value. Adjusted odds ratios and their 95% confidence intervals were also calculated. Results @entity3 was observed in 80/557 (14%) @entity0 . Three independent predictive factors for @entity3 in @entity2 @entity0 were identified: age 49 years, short neck, and neck circumference   43 cm. In the current study th sensitivity for one factor is 0.90 with a specificity 0.35. However, the specificity increased to 0.80 with inclusion of more than one factor. Conclusion According to the current investigation, the three predictive factors are strongly associated with @entity3 in @entity2 @entity0 . Each independent risk factor alone provides a good screening for @entity3 and two factors substantially improve specificity. Based on our analysis, we speculate that the absence of at least 2 of the factors we identified might have a significant negative predictive value and can reasonably exclude @entity3 , with a negative likelihood ratio 0.81.

title: Predictive factors for difficult @entity4 ventilation in the XXXX surgical population.

answer: @entity2


abstract: Background Difficult @entity4 Ventilation ( @entity3 ), is a situation in which it is impossible for an unassisted anesthesiologist to maintain @entity1 saturation >90% using 100% @entity1 and positive pressure ventilation to prevent or reverse signs of inadequate ventilation during @entity4 ventilation.   The incidence varies from 0.08 - 15%. @entity0 -related anatomical features are by far the most significant cause.   We analyzed data from an @entity2 surgical population (BMI> 30 kg/m (2)) to identify specific risk and predictive factors for @entity3 . Methods Five hundred and fifty seven @entity2 @entity0 were identified from a database of 1399 cases associated with preoperative airway examinations where @entity4 ventilation was attempted. Assessment of @entity4 ventilation in this group was stratified by a severity score (0-3), and a step-wise selection method was used to identify independent predictors.   The area under the curve of the receiver-operating-characteristic was then used to evaluate the model's predictive value. Adjusted odds ratios and their 95% confidence intervals were also calculated. Results @entity3 was observed in 80/557 (14%) @entity0 . Three independent predictive factors for @entity3 in @entity2 @entity0 were identified: age 49 years, short neck, and neck circumference   43 cm. In the current study th sensitivity for one factor is 0.90 with a specificity 0.35. However, the specificity increased to 0.80 with inclusion of more than one factor. Conclusion According to the current investigation, the three predictive factors are strongly associated with @entity3 in @entity2 @entity0 . Each independent risk factor alone provides a good screening for @entity3 and two factors substantially improve specificity. Based on our analysis, we speculate that the absence of at least 2 of the factors we identified might have a significant negative predictive value and can reasonably exclude @entity3 , with a negative likelihood ratio 0.81.

title: Predictive factors for difficult XXXX ventilation in the @entity2 surgical population.

answer: @entity4


abstract: The promise of cellular therapy lies in healing damaged tissues and organs in vivo as well as generating tissue constructs in vitro for subsequent transplantation. Adult stem cells are ideally suited for cellular therapies due to their pulripotency and the ease with which they can be cultured on novel functionalized substrates. Creating environments to control and successively driving their differentiation toward a lineage of choice is one of the most important challenges of current cell-based engineering strategies. In recent years, a variety of biomedical platforms have been prepared for stem cell cultures, primarily to provide efficient delivery of growth or survival factors to cells and a conducive microenvironment for their growth. Here, we demonstrate that repeating tetralayer structures composed of biocompatible @entity5 ( @entity5 )/poly( @entity4 ) ( @entity3 )/ @entity5 ( @entity5 )/poly(ethylene oxide)-block-poly(  -caprolactone) ( @entity2 -b-PCL) micelles arrayed in layer-by-layer (LbL) films can serve as a payload region for @entity1 (dex) delivery to @entity0 mesenchymal stem cells (MSCs). This architecture can induce MSC differentiation into osteoblasts in a dose-dependent manner. The amount of dex loaded in the films is controlled by varying the deposition conditions and the film thickness. Furthermore, release of dex is also controlled by changing the amount of covalent crosslinking of multilayers via thermal treatments. The multilayer architecture including payload and cell-adhesion region introduced here are well suited for extended cell culture thus affording the important and protective effect of both dex release and immobilization. These films may find applications in the local delivery of immobilized therapeutics for biomedical applications, as they can be deposited on a wide range of substrates with different shapes, sizes, and composition.

title: Multilayer Thin Film Coatings Capable of Extended Programmable Drug Release: Application to XXXX Mesenchymal Stem Cell Differentiation.

answer: @entity0


abstract: @entity5 @entity1 is a major public health problem. However, in recent years the epidemiology, risk factors, diagnosis, and treatment of @entity5 @entity1 have undergone a significant change. The incidence of @entity5 has increased, not only in the healthcare sector but also in the community. @entity2 and community-acquired disease have different risk factors, with the latter occurring in @entity0 and younger individuals without a history of antibiotic use or previous @entity1 . From a clinician's perspective, a quick efficient diagnosis is required for @entity0 treatment; however, the old method of using enzyme immunoassays is insensitive and not very specific. Recent literature around diagnostic testing for @entity5 @entity1 suggests using PCR or a two-step algorithm to improve sensitivity and specificity. More failures and recurrence with @entity3 have led to treatment algorithms suggesting its use for mild @entity1 and switching to @entity4 if there is no clinical improvement. Alternatively, if signs and symptoms suggest severe @entity1 , then oral @entity4 is recommended as a first-line agent. The addition of a new but costly agent, @entity6 , has seen some disparity between the European and North American guidelines with regard to when it should be used. Lastly, rapid developments and good results with fecal microbial transplantation have also left clinicians wondering about its place in therapy. This article reviews the literature around some of the recent controversies in the field of @entity5 @entity1 .

title: Controversies Around Epidemiology, Diagnosis and Treatment of XXXX Infection.

answer: @entity5


abstract: Two dominant types of action potentials in @entity0 colon are slow wave type action potentials (slow waves) and spike-like action potentials (SLAPs). The slow waves, originating at the submuscular surface where a network of interstitial cells of Cajal (ICCs) is found, possess a pacemaker component. Activation of the pacemaker component is insensitive to voltage changes and L-type @entity1 channel blockers, and is postulated to involve a metabolic clock sensitive to @entity2 . SLAPs are more prominent in the longitudinal muscle. To understand the contribution circular muscle cells make to the generation of these action potentials, a circular muscle preparation (devoid of the submuscular ICC-smooth muscle network, longitudinal muscle, and myenteric plexus) was developed. Circular muscle preparations were spontaneously quiescent, with a resting membrane potential of -62.9 +/- 0.6 mV. @entity5 (0.5 mM) depolarized the cells to -51.8 +/- 0.6 mV and induced @entity4 with a frequency, duration, amplitude, and rate of rise equal to 6.6 +/- 0.4 cpm, 2.2 +/- 0.2 s, 19.4 +/- 0.9 mV, and 21.8 +/- 1.7 mV/s, respectively. In most cases, @entity5 -induced oscillations were preceded by a prepotential of 4.4 +/- 0.3 mV, with a rate of rise of 1.1 +/- 0.1 mV/s. @entity5 -induced oscillations were abolished by 1 microM D600 as well as by repolarization of 6-12 mV. Addition of 0.1 microM @entity6 in the presence of @entity5 further depolarized circular muscle cells to -42.4 +/- 0.8 mV and increased the oscillation frequency to 16.8 +/- 1.8 cpm. The @entity4 induced in circular muscle preparations by @entity5 and @entity6 were similar to the SLAPs exhibited by the isolated longitudinal muscle layer, indicating that generation of SLAPs is an intrinsic property of smooth muscle cells. @entity3 (1 microM), previously shown to dramatically decrease the frequency but not the amplitude of slow waves in preparations including the submuscular ICC network, decreased the amplitude of the @entity5 -induced oscillations in circular muscle preparations without changing the frequency. These results provide strong evidence for the hypothesis that the submuscular ICC-smooth muscle network is essential for the initiation of the pacemaker component of the colonic slow waves. The mechanism for regulating the frequency of slow waves is different from that responsible for the @entity5 -induced oscillations in circular muscle preparations. Circular muscle cells are shown to be excitable and capable of generating oscillatory activity dominated by L-type @entity1 channel activity, which is regulated by K+ conductance.

title: XXXX colonic circular muscle generates action potentials without the pacemaker component.

answer: @entity0


abstract: In 129 @entity0 with @entity2 , a preoperative examination by transvaginal colour Doppler sonography (ATL UM9 HDI) was performed. 45 were malignant and 84 benign. 46 @entity0 were premenopausal and 83 postmenopausal. All @entity1 vessels were analysed by spectrum analysis. The number of @entity1 vessels and the lowest resistance index (RImin) and pulsatility index (PImin) of all vessels were evaluated as diagnostic criteria of the neovascularisation. Up to 19 vessels were found in 115 (89%) @entity1 . In benign lesions, the number of vessels was significantly lower than in @entity1 (median 3 versus 9, p < 0.0001). The RImin and PImin values between benign and @entity1 were also significantly different, independent of the menopausal status. In postmenopausal @entity0 , the median RImin in 42 @entity1 was 0.62 (0.26-1.0) and in 41 @entity1 0.40 (0.22-0.66). The median PImin was 0.98 (0.31-5.84) in @entity1 and 0.53 (0.25-1.22) in @entity1 . However, due to the overlapping range between benign and @entity1 , these parameters do not allow an accurate differentiation. With a cut off value for RImin = 0.5 and PImin = 0.7, the sensitivity is 85% or 82.5% respectively. The specificity for RImin and PImin is 77%, and the diagnostic accuracy is 84% and 80% respectively. The correlation coefficient between RImin and PImin is 0.99 in benign and @entity1 and both indices are adequate. The calculation of the RI is more easily available and should be preferred as a diagnostic parameter.

title: [Transvaginal color-coded Doppler ultrasound in XXXX ].

answer: @entity2


abstract: UNASSIGNED: Primary @entity7 is potentially a devastating disease, responsible for half of @entity3 -related @entity6 worldwide. Angle closure is characterized by appositional approximation or contact between the iris and trabecular meshwork. It tends to develop in eyes with shallow anterior chambers, anteriorly positioned or pushed lenses, and angle crowding. Risk of primary @entity7 is high among @entity0 , the elderly and the hyperopic, and it is most prevalent in Asia. Investigation into genetic mechanisms of @entity3 inheritance is underway. Diagnosis relies on gonioscopy and may be aided by anterior segment optical coherence tomography and ultrasound biomicroscopy. Treatment is designed to control intraocular pressure while monitoring changes to the angle and optic nerve head. Treatment typically begins with medical management through pressure-reducing topical medications. @entity5 is often performed to alleviate @entity2 , while laser iridoplasty has been found effective for mechanisms of closure other than @entity2 , such as @entity4 . Phacoemulsification, with or without goniosynechialysis, both in eyes with existing @entity1 and in those with clear lenses, is thus far a viable treatment alternative. Long-term research currently underway will examine its efficacy in cases of angle closure in early stages of the disease. Endoscopic cyclophotocoagulation is another treatment option, which can be combined with @entity1 surgery. Trabeculectomy remains effective therapy for more advanced cases.

title: Primary XXXX : an update.

answer: @entity7


abstract: UNASSIGNED: The   opioid receptor ( @entity0 ) and @entity2 ( @entity2 ) have been implicated in pair-bond formation and maintenance in socially monogamous species. Utilizing monogamous @entity1 (Callicebus cupreus), the present study examined the potential role opioids play in modulating the response to separation, a potent challenge to the pair-bond. In Experiment 1, paired male @entity1 were separated from their pair-mate for 30-min and then received saline, naloxone (1.0mg/kg), morphine (0.25mg/kg), or the @entity2 agonist, U50,488 (0.01, 0.03, or 0.1mg/kg) in a counter-balanced fashion, immediately prior to a 30-min reunion with their mate. Blood samples were collected immediately prior to and after the reunion. Males receiving morphine approached females less, initiated contact less, and females broke contact with the males less. The increase in cortisol in response to naloxone was greater compared to vehicle, and the increase in cortisol in response to the high dose of U50,488 compared to vehicle approached significance. In Experiment 2, paired males were treated with the @entity2 antagonist, @entity3 (0.1, 0.3, or 1.0mg/kg), or saline 24h prior to a 60-min separation from their mate. Blood samples were collected at the time of injection and immediately before and after separation. Administration of the low dose of @entity3 decreased the locomotor component of the separation response compared to vehicle. The present study found that the opioid system is involved in both the affiliative and separation distress components of a pair-bond, and these components are regulated by different opioid receptors.

title: The effects of morphine, naloxone, and k opioid manipulation on endocrine functioning and social behavior in monogamous XXXX (Callicebus cupreus).

answer: @entity1


abstract: One hundred @entity0 with frequent (> 1,000 beats/day) @entity2 ( @entity2 ) were followed for 4 years. All of the @entity0 , except those with @entity1 (n = 8), were classified into 3 groups based on their outcome. Group A consisted of 29 @entity0 with idiopathic @entity2 who survived the study period. Group B consisted of 49 @entity0 with underlying diseases who survived the study period. Group C consisted of 14 @entity0 who suffered @entity1 . There was no significant difference in the daily number of @entity2 . However, groups B and C had more @entity0 with Lown grade 4a or 4b @entity2 than group A. The mean coupling interval was significantly longer in group C than in group A, and the standard deviation of the coupling interval was significantly larger in group C than in group A. Forty @entity0 underwent serial Holter monitorings to assess changes in the number of @entity2 . @entity2 spontaneously decreased in 13 @entity0 , while the other 27 @entity0 continued to have frequent @entity2 . Most of these 13 @entity0 were classified as Lown grade 2. The results suggest that in @entity0 with frequent @entity2 , longer and more varied coupling intervals may predict a poor prognosis, and Lown grade 2 may predict a spontaneous regression.

title: Characteristics of XXXX and their clinical course.

answer: @entity2


abstract: @entity6 ( @entity6 ) is a chronic @entity1 consisting of recurrent nodules, sinuses, @entity2 and scarring involving the intertriginous regions. @entity6 is often a therapeutic challenge and most treatments are off-label. A better understanding of aetiology and pathogenesis of @entity6 may facilitate the development of effective treatment. Although the clinical presentation is strongly reminiscent of @entity7 remains controversial. Studies have isolated an array of different bacteria specimens. Consistent findings of Gram-positive cocci and Gram-positive rods including @entity3 , coagulase-negative staphylococci (CoNS) and Corynebacterium species in deep tissue samples have been demonstrated in @entity6 and may constitute a central target for the immune system. Efficacy of antibiotics, that is @entity5 , @entity8 or @entity4 , supports a microbial role in disease pathogenesis. However, these antibiotics also work as immunomodulators of especially T cells, and the underlying mechanisms may therefore be more complex. We performed a systematic review of previous studies investigating the bacterial flora in @entity9 suppurativa. We searched PubMed, EMBASE, Royal Danish Library and Cochrane library (search date 11 December 2014). A total of 66 papers were identified and nine papers published between 1988 and 2014 matched our inclusion criteria, yielding bacteriological data of a total of 324 @entity0 with @entity6 (mean age 36.8  years and female/male ratio 215/109). This overview of the bacteriology may aid researchers and physicians exploring the potential role of bacteria in @entity6 . Furthermore, to stimulate a broader debate, we also present different viewpoints on the possible role of bacteria in @entity6 .

title: The bacteriology of XXXX suppurativa: a systematic review.

answer: @entity9


abstract: Objective. The dorsal root ganglion is an attractive target for implanting neural electrode arrays that restore sensory function or provide therapy via stimulation. However, penetrating microelectrodes designed for these applications are small and deliver low currents. For long-term performance of microstimulation devices, novel coating materials are needed in part to decrease impedance values at the electrode-tissue interface and to increase charge storage capacity. Approach. Conductive polymer @entity8 ( @entity9 ) and multi-wall @entity0 nanotubes (CNTs) were coated on the electrode surface and doped with the anti-inflammatory drug, @entity3 . Electrode characteristics and the tissue reaction around neural electrodes as a result of stimulation, coating and drug release were characterized. @entity4 and @entity5 staining along with antibodies recognizing @entity7 (microglia/macrophages), NF200 (neuronal axons), NeuN (neurons), @entity6 (fibroblasts), @entity1 (cell death) and L1 (neural cell adhesion molecule) were used. Quantitative image analyses were performed using MATLAB. Main results. Our results indicate that coated microelectrodes have lower in vitro and in vivo impedance values. Significantly less @entity2 /damage was observed with coated electrodes as compared to non-coated controls. The inflammatory response with the @entity9 /CNT-coated electrodes was also reduced. Significance. This study is the first to report on the utility of these coatings in stimulation applications. Our results indicate @entity9 /CNT coatings may be valuable additions to implantable electrodes used as therapeutic modalities.

title: Evaluation of @entity8 / XXXX nanotube neural electrode coatings for stimulation in the dorsal root ganglion.

answer: @entity0


abstract: Objective. The dorsal root ganglion is an attractive target for implanting neural electrode arrays that restore sensory function or provide therapy via stimulation. However, penetrating microelectrodes designed for these applications are small and deliver low currents. For long-term performance of microstimulation devices, novel coating materials are needed in part to decrease impedance values at the electrode-tissue interface and to increase charge storage capacity. Approach. Conductive polymer @entity8 ( @entity9 ) and multi-wall @entity0 nanotubes (CNTs) were coated on the electrode surface and doped with the anti-inflammatory drug, @entity3 . Electrode characteristics and the tissue reaction around neural electrodes as a result of stimulation, coating and drug release were characterized. @entity4 and @entity5 staining along with antibodies recognizing @entity7 (microglia/macrophages), NF200 (neuronal axons), NeuN (neurons), @entity6 (fibroblasts), @entity1 (cell death) and L1 (neural cell adhesion molecule) were used. Quantitative image analyses were performed using MATLAB. Main results. Our results indicate that coated microelectrodes have lower in vitro and in vivo impedance values. Significantly less @entity2 /damage was observed with coated electrodes as compared to non-coated controls. The inflammatory response with the @entity9 /CNT-coated electrodes was also reduced. Significance. This study is the first to report on the utility of these coatings in stimulation applications. Our results indicate @entity9 /CNT coatings may be valuable additions to implantable electrodes used as therapeutic modalities.

title: Evaluation of XXXX / @entity0 nanotube neural electrode coatings for stimulation in the dorsal root ganglion.

answer: @entity8


abstract: UNASSIGNED: Early brain development is a complex and rapid process, the disturbance of which may cause the onset of @entity1 . Based on longitudinal imaging data acquired from 6 to 16months postnatal, we describe a systematic trajectory of monkey brain development during late infancy, and demonstrate the influence of @entity4 ( @entity2 ) on this trajectory. Although the general developmental trajectory of the monkey brain was close to that of the @entity0 brain, the development in monkeys was faster and regionally specific. Gray matter volume began to decrease during late infancy in monkeys, much earlier than in @entity0 in whom it occurs in adolescence. Additionally, the decrease of gray matter volume in higher-order association regions (the frontal, parietal and temporal lobes) occurred later than in regions for primary functions (the occipital lobe and cerebellum). White matter volume displayed an increasing trend in most brain regions, but not in the occipital lobe, which had a stable volume. In addition, based on diffusion tensor imaging, we found an increase in fractional anisotropy and a decrease in diffusivity, which may be associated with myelination and axonal changes in white matter tracts. Meanwhile, we tested the influence of 14-day @entity2 treatment on the developmental trajectories. Such treatment tended to accelerated brain maturation during late infancy, although not statistically significant. These findings provide comparative information for the understanding of primate brain maturation and @entity3 .

title: Rhesus monkey brain development during late infancy and the effect of XXXX : A longitudinal MRI and DTI study.

answer: @entity4


abstract: @entity1 ( @entity1 ) has been applied to prepare high-quality ultrathin films for microelectronics, catalysis, and energy applications. The possible pathways for @entity3 @entity1 using aminosilanes and O2 plasma have been investigated by density functional theory calculations. The @entity6 half-reaction between @entity6 and surface - @entity2 is very difficult and requires a high activation free energy of 57.8 kcal mol(-1). The introduction of an aminosilane, such as BDMAS, can reduce the activation free energy to 11.0 kcal mol(-1) and the aminosilane plays the role of a self-catalyst in @entity9 formation through the relevant half-reaction. Among the various species generated in O2 plasma, (3)O2 is inactive towards surface @entity6 groups, similar to ordinary @entity0 gas. The other three species, (1)O2, (1)O, and (3)O, can strongly oxidize surface @entity6 groups through one-step or stepwise pathways. In the (3)O pathway, the triplet must be converted into the singlet and follow the (1)O pathway. Meanwhile, both (1)O and (3)O can decay to (1)O2 and enter into the relevant oxidation pathway. The concept of self-catalysis of aminosilanes may be invoked to design and prepare more effective Si precursors for @entity3 @entity5 . At the same time, the mechanism of strong surface oxidation by O2 plasma may be exploited in the @entity1 preparation of other @entity8 , such as @entity7 , HfO2, ZrO2, and @entity4 .

title: Self-catalysis by aminosilanes and strong surface oxidation by O2 plasma in plasma-enhanced @entity1 of high-quality XXXX .

answer: @entity3


abstract: @entity1 ( @entity1 ) has been applied to prepare high-quality ultrathin films for microelectronics, catalysis, and energy applications. The possible pathways for @entity3 @entity1 using aminosilanes and O2 plasma have been investigated by density functional theory calculations. The @entity6 half-reaction between @entity6 and surface - @entity2 is very difficult and requires a high activation free energy of 57.8 kcal mol(-1). The introduction of an aminosilane, such as BDMAS, can reduce the activation free energy to 11.0 kcal mol(-1) and the aminosilane plays the role of a self-catalyst in @entity9 formation through the relevant half-reaction. Among the various species generated in O2 plasma, (3)O2 is inactive towards surface @entity6 groups, similar to ordinary @entity0 gas. The other three species, (1)O2, (1)O, and (3)O, can strongly oxidize surface @entity6 groups through one-step or stepwise pathways. In the (3)O pathway, the triplet must be converted into the singlet and follow the (1)O pathway. Meanwhile, both (1)O and (3)O can decay to (1)O2 and enter into the relevant oxidation pathway. The concept of self-catalysis of aminosilanes may be invoked to design and prepare more effective Si precursors for @entity3 @entity5 . At the same time, the mechanism of strong surface oxidation by O2 plasma may be exploited in the @entity1 preparation of other @entity8 , such as @entity7 , HfO2, ZrO2, and @entity4 .

title: Self-catalysis by aminosilanes and strong surface oxidation by O2 plasma in plasma-enhanced XXXX of high-quality @entity3 .

answer: @entity1


abstract: UNASSIGNED: Mean platelet volume ( @entity5 ) is the measure of platelet size. @entity5 possibly is a simple way to estimate platelet activity. In this study, we aimed to investigate @entity5 levels in @entity4 @entity0 . Fifty-one euthyroid @entity0 with @entity4 attending our outpatient clinic of the endocrinology department, and 51 age and BMI-matched healthy individuals were included in this study. All @entity0 with @entity4 were at euthyroid state. None of the study @entity0 was subjected to @entity3 replacement therapy. Anti-thyroid peroxidase (anti-TPO) antibody and anti-tiroglobulin antibody were positive. All the study @entity0 were evaluated by biochemical and platelet parameters. There were no significant differences in age (33.88  12.87 and 30.18  12.43 years, respectively; P>0.05) and BMI (23.55  3.34 and 22.25  3.65kg/m, respectively, P>0.05) between the study and the control groups. Anti-TPO and anti-tiroglobulin levels were significantly higher in the study group (anti-TPO 428.32  668.39IU/ml in the @entity4 group; 14.85  9.66IU/ml in the control group, P=0.001; anti-tiroglobulin 320.46  796.05IU/ml in the @entity4 group, 21.28  26.24IU/ml in the control group, P=0.09). There were no significant differences in terms of serum thyroid-stimulating hormone (TSH) (1.76  0.79 and 1.85  1.14uIU/ml, respectively), FT3 (3.10  0.37 and 3.29  0.76pg/ml, respectively) and FT4 (1.22  0.42 and 1.46  0.78pg/ml, respectively) levels between the study and the control groups. Serum @entity2 levels were significantly higher in the study group than in the control group (133.81  91.50 and 90.18  41.15mg/dl, respectively; P=0.015). Mean @entity5 levels were significantly higher in the @entity4 group than in the control @entity0 (8.8  1.05 and 7.9  0.79 fl, respectively; P=0.0001). To assess the correlation with @entity5 , a Pearson's correlation analysis was performed on each variable. There were positive correlations between anti-TPO and @entity5 levels (r=0.246, P=0.042), and between anti-tiroglobulin and @entity5 levels (r=0.256, P=0.033). The multiple regression analysis of @entity5 and other risk factors was performed. Age, BMI, C-reactive protein and waist circumference were independent predictive factors of @entity5 . Adjustment for other factors did not alter these relative risks. Our results suggest that even if in euthyroid state, @entity0 with @entity4 have higher @entity5 levels than the healthy controls. As higher @entity5 levels are closely related with @entity1 , @entity4 @entity0 have greater risk of atherothrombotic complications than controls.

title: Mean platelet volume in euthyroid @entity0 with XXXX .

answer: @entity4


abstract: UNASSIGNED: Mean platelet volume ( @entity5 ) is the measure of platelet size. @entity5 possibly is a simple way to estimate platelet activity. In this study, we aimed to investigate @entity5 levels in @entity4 @entity0 . Fifty-one euthyroid @entity0 with @entity4 attending our outpatient clinic of the endocrinology department, and 51 age and BMI-matched healthy individuals were included in this study. All @entity0 with @entity4 were at euthyroid state. None of the study @entity0 was subjected to @entity3 replacement therapy. Anti-thyroid peroxidase (anti-TPO) antibody and anti-tiroglobulin antibody were positive. All the study @entity0 were evaluated by biochemical and platelet parameters. There were no significant differences in age (33.88  12.87 and 30.18  12.43 years, respectively; P>0.05) and BMI (23.55  3.34 and 22.25  3.65kg/m, respectively, P>0.05) between the study and the control groups. Anti-TPO and anti-tiroglobulin levels were significantly higher in the study group (anti-TPO 428.32  668.39IU/ml in the @entity4 group; 14.85  9.66IU/ml in the control group, P=0.001; anti-tiroglobulin 320.46  796.05IU/ml in the @entity4 group, 21.28  26.24IU/ml in the control group, P=0.09). There were no significant differences in terms of serum thyroid-stimulating hormone (TSH) (1.76  0.79 and 1.85  1.14uIU/ml, respectively), FT3 (3.10  0.37 and 3.29  0.76pg/ml, respectively) and FT4 (1.22  0.42 and 1.46  0.78pg/ml, respectively) levels between the study and the control groups. Serum @entity2 levels were significantly higher in the study group than in the control group (133.81  91.50 and 90.18  41.15mg/dl, respectively; P=0.015). Mean @entity5 levels were significantly higher in the @entity4 group than in the control @entity0 (8.8  1.05 and 7.9  0.79 fl, respectively; P=0.0001). To assess the correlation with @entity5 , a Pearson's correlation analysis was performed on each variable. There were positive correlations between anti-TPO and @entity5 levels (r=0.246, P=0.042), and between anti-tiroglobulin and @entity5 levels (r=0.256, P=0.033). The multiple regression analysis of @entity5 and other risk factors was performed. Age, BMI, C-reactive protein and waist circumference were independent predictive factors of @entity5 . Adjustment for other factors did not alter these relative risks. Our results suggest that even if in euthyroid state, @entity0 with @entity4 have higher @entity5 levels than the healthy controls. As higher @entity5 levels are closely related with @entity1 , @entity4 @entity0 have greater risk of atherothrombotic complications than controls.

title: Mean platelet volume in euthyroid XXXX with @entity4 .

answer: @entity0


abstract: A DFT study using B3LYP/6-31G(d,p) level of theory is pursued to investigate the energy and geometry changes of @entity2 isomers in the S0, D0(+), and D0(-). In S0, @entity0 azidopyridine is the most stable, followed by cyclic tetrazole and trans isomer is the least stable. In D0(+), the cis isomer is the most stable, followed by trans isomer, and @entity1 isomer is the least stable. In the D0(-) state, the trans form is the most stable, followed by the cis and the tetrazolo form is the least stable. Single point vertical excitation energy calculations of the cis form gave four excited states at 266.4, 239.4, 199.4, and 196.1nm, all having   -  (   ) character. For trans isomer, five excited states at, 256.7, 250.3, 229.7, 199.0, 197.0nm all resulting from   -  (   ) transitions. For the @entity1 isomer, seven excited states at 269.3, 242.7, 198.0, 187.2, 183.9, 182.1, 178.7nm all resulting from   -  (   ) transitions. The geometries of the 3 isomers show noticeable changes in bond lengths, bond angles and dihedral angles, upon ionization and electron attachment. The ionization results in a remarkable variation of the NBO atomic charges as a result of ionization and electron attachment. where electron density of HOMO of the D0(+) state is found to be much lower than that of the HOMO of the S0 in the case of ionization. The dipole moment calculations show that @entity1 isomer has the largest polarization in the S0 state, followed by cis isomer and trans isomer is the least polarized. The same pattern is found in the D0(+) state. In the D0(-) state, trans isomer is the highest polarized, followed by the cis, and @entity1 isomer is the least polarized. The rotational constants calculations of cis- isomer show that the cation is elongated along the long in-plane axis and compressed along the two short out-of-plane axes while the anion is compressed along the long in-plane axis, and elongated along the two short out-of plane axes. The cation and anion of trans isomer show similar behavior to the cis isomer. The cation of cyclic tetrazole, is compressed along the long in-plane axis and elongated along the two short out-of-plane axes, while the anion elongates along the 3 mutually perpendicular axes.

title: A DFT study of the ionization and electron attachment of XXXX .

answer: @entity2


abstract: OBJECTIVE: Wound age determination in living subjects is important in routine diagnostics in forensic medicine. Macroscopical description of a wound to determine wound age however is inadequate. The aim of this study was to assess whether it would be feasible to determine wound age via analysis of morphological characteristics and extracellular matrix proteins in skin biopsies of living subjects referred to a forensic outpatient clinic. METHODS: Skin biopsies (n=101), representing the border area of the wound, were taken from skin injuries of known wound age (range: 4.5h-25days) in living subjects. All biopsies were analyzed for 3 morphological features ( @entity2 , @entity4 and @entity1 ) and 3 extracellular matrix markers (collagen III, collagen IV and @entity3 ). For quantification, biopsies were subdivided in 4 different timeframes: 0.2-2 days, 2-4 days, 4-10 days and 10-25 days old wounds. Subsequently, a probability scoring system was developed. RESULTS: For @entity1 , collagen III, collagen IV and @entity3 expression no relation with wound age was found. Ulceration was only found in wounds of 0.2-2, 2-4 and 4-10 days old, implying that the probability that a wound was more than 10 days old in case of @entity2 is equal to 0%. Also @entity4 was almost exclusively found in wounds of 0.2-2, 2-4 and 4-10 days old, except for one case with a wound age of 15 days old. The probability scoring system of all analyzed markers, as depicted above, however can be used to calculate individual wound age probabilities in biopsies of @entity0 of living subjects. CONCLUSIONS: We have developed a probability scoring system, analysing morphological characteristics and extracellular matrix proteins in superficial skin biopsies of wounds in living subjects that can be applied in forensic medicine for wound age determination.

title: Analysis of morphological characteristics and expression levels of extracellular matrix proteins in XXXX to determine wound age in living subjects in forensic medicine.

answer: @entity0


abstract: OBJECTIVES:: Traditionally, the anterior surgical approach of choice for acetabular reconstruction was ilioinguinal. There has been an increasing usage of the midline "Stoppa" or "anterior intrapelvic approach." The aim is to report the techniques, early results (minimum 1 year), and complications of anterior approaches for acetabular reconstruction. DESIGN:: Retrospective case-note review. SETTING:: Pelvic and acetabular tertiary center. @entity0 :: A consecutive series of acetabular fractures treated at 1 tertiary specialist unit were retrospectively reviewed. The @entity3 patterns, incisions used, intraoperative and postoperative complications, reduction achieved (measured on postoperative radiographs and computed tomography scans), and early postoperative results (minimum 1-year follow-up), were recorded. MAIN OUTCOME MEASUREMENTS:: Postoperative reduction (measured by postoperative plain radiographs and computed tomography). RESULTS:: Of 160 consecutive @entity0 who underwent acetabular reconstruction, 56 (mean age, 44 years) underwent reconstruction using only anterior approaches (mean of 7 days after injury). Iatrogenic complications, @entity2 , @entity4 , and avascular @entity1 rates are comparable with the literature. Overall, anatomic reduction was seen in 71% of cases and concentric reconstruction of the dome in over 90%. Thirty-six of the 56 @entity0 (64%) were symptom-free at the latest follow-up and 34 (61%) had returned to work. CONCLUSIONS:: The results reported suggest the use of dual approaches using the lateral 2 windows, and/or a midline anterior intrapelvic approach in anterior acetabular reconstructions has a relatively low complication rate and can lead to anatomic reconstructions in 71%. LEVEL OF EVIDENCE:: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

title: The Modified Ilioinguinal and Anterior Intrapelvic Approaches for XXXX Fixation: Indications, Quality of Reduction, and Early Outcome.

answer: @entity3


abstract: PURPOSE: The aim of this study was to examine the clinical outcomes of treating @entity2 at the skull base region following surgical resection and adjuvant radiotherapy, and to analyze the association between clinical characteristics and progression free survival. MATERIALS AND METHODS: Twenty-eight @entity0 with skull base atypical @entity2 underwent microsurgical resection between June 2001 and November 2009. The clinical characteristics of the @entity0 and @entity2 , the extent of surgical resection, and complications after treatment were retrospectively analyzed. RESULTS: Thirteen @entity0 (46.4%) had disease recurrence or progression during follow up time. The median time to disease progression was 64 months. The extent of the surgical resection significantly impacted prognosis. Gross total resection (GTR) of the @entity1 improved progression free survival (PFS) compared to subtotal resection (STR, p=0.011). An older @entity0 age at diagnosis also resulted in a worse outcome (p=0.024). An @entity3 index <8% also contributed to improved PFS (p=0.031). None of the @entity0 that underwent GTR and received adjuvant radiotherapy had @entity1 recur during follow up. STR with adjuvant radiotherapy tended to result in better local @entity1 control than STR alone (p=0.074). Three of 28 @entity0 (10.7%) developed complications after microsurgery. The GTR group had a higher rate of complications than those with STR. There were no late adverse effects after adjuvant radiotherapy during follow up. CONCLUSION: For @entity0 with skull base atypical @entity2 , GTR is desirable for longer PFS, unless radical excision is expected to lead to severe complications. Adjuvant radiation therapy is advisable to reduce @entity1 recurrence regardless of the extent of surgical resection. Age of disease onset and the @entity3 index of the @entity1 were both independent prognostic factors of clinical outcome.

title: Skull base XXXX : Long term surgical outcome and prognostic factors.

answer: @entity2


abstract: The @entity7 ( @entity7 ), a @entity1 -like illness in sickle cell @entity0 , is one of the most frequent causes of their morbidity and hospitalizations. Repeated @entity7 events may predict the development of @entity4 . @entity7 is reported as a frequent cause of @entity2 in these @entity0 . We examine here the incidence and risk factors of @entity7 in 3,751 @entity0 with @entity6 who were observed prospectively for at least 2 years (19,867 @entity0 -years [pt-yrs]) as part of a multicenter national study group. The @entity7 , defined by a new pulmonary infiltrate on x-ray, occurred at least once in 1,085 @entity0 (2,100 events). @entity7 incidence was higher in @entity0 with homozygous @entity6 (SS; 12.8/100 pt-yrs) and in @entity0 with sickle cell-beta(0) -thalassemic (9.4/100 pt-yrs), and lower in @entity0 with hemoglobin (Hb) @entity9 (5.2/100 pt-yrs) and @entity0 with sickle cell-beta(+) @entity5 (3.9/100 pt-yrs). @entity8 did not affect the rate of @entity7 incidence in SS @entity0 . Within each Hb type the incidence was strongly but inversely related to age, being highest in @entity0 2 to 4 years of age (25.3/100 pt-yrs in SS) and decreasing gradually to its lowest value in adults (8.8/100 pt-yrs in SS). In SS @entity0 (< 10 years of age), we documented an age-related within- @entity0 reduction in @entity7 attack rates. Adults with a higher @entity7 rate had a higher rate of mortality (from all causes) than those with low @entity7 rates. This increased rate of mortality might also have contributed to the decline in @entity7 rate with age. In multivariate analysis, other factors affecting incidence in SS @entity0 were degree of @entity3 (lower @entity7 rates in @entity0 with lower steady-state Hb levels) and fetal Hb (lower rates in @entity0 with high fetal Hb). There was also a positive association between @entity7 rate and steady-state leukocyte count. The relationship of @entity7 rate to higher steady-state Hb levels in SS @entity0 is unexplained but might be caused by increased blood viscosity.

title: The @entity7 in @entity6 : incidence and risk factors. The Cooperative Study of XXXX .

answer: @entity6


abstract: The @entity7 ( @entity7 ), a @entity1 -like illness in sickle cell @entity0 , is one of the most frequent causes of their morbidity and hospitalizations. Repeated @entity7 events may predict the development of @entity4 . @entity7 is reported as a frequent cause of @entity2 in these @entity0 . We examine here the incidence and risk factors of @entity7 in 3,751 @entity0 with @entity6 who were observed prospectively for at least 2 years (19,867 @entity0 -years [pt-yrs]) as part of a multicenter national study group. The @entity7 , defined by a new pulmonary infiltrate on x-ray, occurred at least once in 1,085 @entity0 (2,100 events). @entity7 incidence was higher in @entity0 with homozygous @entity6 (SS; 12.8/100 pt-yrs) and in @entity0 with sickle cell-beta(0) -thalassemic (9.4/100 pt-yrs), and lower in @entity0 with hemoglobin (Hb) @entity9 (5.2/100 pt-yrs) and @entity0 with sickle cell-beta(+) @entity5 (3.9/100 pt-yrs). @entity8 did not affect the rate of @entity7 incidence in SS @entity0 . Within each Hb type the incidence was strongly but inversely related to age, being highest in @entity0 2 to 4 years of age (25.3/100 pt-yrs in SS) and decreasing gradually to its lowest value in adults (8.8/100 pt-yrs in SS). In SS @entity0 (< 10 years of age), we documented an age-related within- @entity0 reduction in @entity7 attack rates. Adults with a higher @entity7 rate had a higher rate of mortality (from all causes) than those with low @entity7 rates. This increased rate of mortality might also have contributed to the decline in @entity7 rate with age. In multivariate analysis, other factors affecting incidence in SS @entity0 were degree of @entity3 (lower @entity7 rates in @entity0 with lower steady-state Hb levels) and fetal Hb (lower rates in @entity0 with high fetal Hb). There was also a positive association between @entity7 rate and steady-state leukocyte count. The relationship of @entity7 rate to higher steady-state Hb levels in SS @entity0 is unexplained but might be caused by increased blood viscosity.

title: The @entity7 in XXXX : incidence and risk factors. The Cooperative Study of @entity6 .

answer: @entity6


abstract: The @entity7 ( @entity7 ), a @entity1 -like illness in sickle cell @entity0 , is one of the most frequent causes of their morbidity and hospitalizations. Repeated @entity7 events may predict the development of @entity4 . @entity7 is reported as a frequent cause of @entity2 in these @entity0 . We examine here the incidence and risk factors of @entity7 in 3,751 @entity0 with @entity6 who were observed prospectively for at least 2 years (19,867 @entity0 -years [pt-yrs]) as part of a multicenter national study group. The @entity7 , defined by a new pulmonary infiltrate on x-ray, occurred at least once in 1,085 @entity0 (2,100 events). @entity7 incidence was higher in @entity0 with homozygous @entity6 (SS; 12.8/100 pt-yrs) and in @entity0 with sickle cell-beta(0) -thalassemic (9.4/100 pt-yrs), and lower in @entity0 with hemoglobin (Hb) @entity9 (5.2/100 pt-yrs) and @entity0 with sickle cell-beta(+) @entity5 (3.9/100 pt-yrs). @entity8 did not affect the rate of @entity7 incidence in SS @entity0 . Within each Hb type the incidence was strongly but inversely related to age, being highest in @entity0 2 to 4 years of age (25.3/100 pt-yrs in SS) and decreasing gradually to its lowest value in adults (8.8/100 pt-yrs in SS). In SS @entity0 (< 10 years of age), we documented an age-related within- @entity0 reduction in @entity7 attack rates. Adults with a higher @entity7 rate had a higher rate of mortality (from all causes) than those with low @entity7 rates. This increased rate of mortality might also have contributed to the decline in @entity7 rate with age. In multivariate analysis, other factors affecting incidence in SS @entity0 were degree of @entity3 (lower @entity7 rates in @entity0 with lower steady-state Hb levels) and fetal Hb (lower rates in @entity0 with high fetal Hb). There was also a positive association between @entity7 rate and steady-state leukocyte count. The relationship of @entity7 rate to higher steady-state Hb levels in SS @entity0 is unexplained but might be caused by increased blood viscosity.

title: The XXXX in @entity6 : incidence and risk factors. The Cooperative Study of @entity6 .

answer: @entity7


abstract: Conventional pedicled-flap based surgeries in treating @entity0 have their limitations. New surgical regimens are yet to be explored, which will follow the oncological principle of being "total @entity3 free", whilst fit into the unique characteristics of China's own medical system as well as @entity1 ' demand. From 2007 to 2013, 143 @entity1 with early @entity0 were included in the study, with the average age of 46.1 years. Fifty-three @entity1 were subjected to modified breast conserving surgery (MBCS)+latissimus dorsi (LD) flap reconstruction, 41 to skin sparing mastectomy (SSM)+implant+LD flap reconstruction, 29 to MBCS+distal transverse rectus abdominis myocutaneous (DTRAM) flap reconstruction, and 20 to SSM+DTRAM flap reconstruction. The results showed that out of the 143 @entity1 , there was no graft loss. Minor complications included 4 cases of fat liquefaction, and 6 cases of seratoma, which all resolved after conservative treatment. Five @entity1 had visible protuberance in the abdomen, but not leading to any @entity4 . The reconstructed breasts all presented good shape. 96.7% of the @entity1 were satisfied with the outcome. The follow-up period varied from 6 months to 60 months, and only one @entity1 died from @entity3 @entity2 in the brain. No local recurrence occurred. It was concluded that these two modified pedicled-flap surgeries are readily practical, and aesthetically satisfactory, with high applicability in China. They do not compromise the oncological outcomes, but also are well-accepted by Chinese @entity1 .

title: Two modified surgical procedures for treating early XXXX in China.

answer: @entity0


abstract: The influence of (+/-)- @entity3 and @entity6 on stress- and various chemically-induced @entity5 in @entity0 together with their influence on various biochemical parameters which affect the development of the induced @entity1 was examined. Pretreatment of @entity0 with (+/-)- @entity3 (4-16 mg kg-1 orally) significantly decreased cold-stress-induced @entity5 and enhanced @entity2 -induced @entity1 . It did not affect @entity8 - (30 mg kg-1 orally) or @entity7 - (5 mg kg-1 i.p.) induced @entity1 . Pretreatment of the animals with @entity6 (1-10 mg kg-1 orally) significantly enhanced @entity2 -, @entity7 - and cold-stress-induced @entity1 . It did not affect @entity8 -induced @entity1 . Pretreatment of the animals with @entity3 increased gastric mucus secretion, inhibited gastric acid secretion, decreased @entity4 content and enhanced gastric lipid peroxidation whereas pretreatment of the animals with @entity6 significantly decreased gastric mucus secretion. @entity6 did not affect gastric acid secretion, @entity4 or gastric lipid peroxidation. The results of this study suggest that @entity3 -induced protection against stress-induced @entity1 may be due to its ability to suppress gastric acid secretion and to increase gastric mucus secretion. Its enhancement of @entity2 -induced @entity1 may be due to its ability to increase lipid peroxidation. The @entity6 -induced enhancement of the experimentally-induced @entity1 may be due to its ability to suppress gastric mucus secretion.

title: Effect of (+/-)- @entity3 and XXXX on stress- and chemically-induced @entity5 in @entity0 .

answer: @entity6


abstract: The influence of (+/-)- @entity3 and @entity6 on stress- and various chemically-induced @entity5 in @entity0 together with their influence on various biochemical parameters which affect the development of the induced @entity1 was examined. Pretreatment of @entity0 with (+/-)- @entity3 (4-16 mg kg-1 orally) significantly decreased cold-stress-induced @entity5 and enhanced @entity2 -induced @entity1 . It did not affect @entity8 - (30 mg kg-1 orally) or @entity7 - (5 mg kg-1 i.p.) induced @entity1 . Pretreatment of the animals with @entity6 (1-10 mg kg-1 orally) significantly enhanced @entity2 -, @entity7 - and cold-stress-induced @entity1 . It did not affect @entity8 -induced @entity1 . Pretreatment of the animals with @entity3 increased gastric mucus secretion, inhibited gastric acid secretion, decreased @entity4 content and enhanced gastric lipid peroxidation whereas pretreatment of the animals with @entity6 significantly decreased gastric mucus secretion. @entity6 did not affect gastric acid secretion, @entity4 or gastric lipid peroxidation. The results of this study suggest that @entity3 -induced protection against stress-induced @entity1 may be due to its ability to suppress gastric acid secretion and to increase gastric mucus secretion. Its enhancement of @entity2 -induced @entity1 may be due to its ability to increase lipid peroxidation. The @entity6 -induced enhancement of the experimentally-induced @entity1 may be due to its ability to suppress gastric mucus secretion.

title: Effect of (+/-)- XXXX and @entity6 on stress- and chemically-induced @entity5 in @entity0 .

answer: @entity3


abstract: The influence of (+/-)- @entity3 and @entity6 on stress- and various chemically-induced @entity5 in @entity0 together with their influence on various biochemical parameters which affect the development of the induced @entity1 was examined. Pretreatment of @entity0 with (+/-)- @entity3 (4-16 mg kg-1 orally) significantly decreased cold-stress-induced @entity5 and enhanced @entity2 -induced @entity1 . It did not affect @entity8 - (30 mg kg-1 orally) or @entity7 - (5 mg kg-1 i.p.) induced @entity1 . Pretreatment of the animals with @entity6 (1-10 mg kg-1 orally) significantly enhanced @entity2 -, @entity7 - and cold-stress-induced @entity1 . It did not affect @entity8 -induced @entity1 . Pretreatment of the animals with @entity3 increased gastric mucus secretion, inhibited gastric acid secretion, decreased @entity4 content and enhanced gastric lipid peroxidation whereas pretreatment of the animals with @entity6 significantly decreased gastric mucus secretion. @entity6 did not affect gastric acid secretion, @entity4 or gastric lipid peroxidation. The results of this study suggest that @entity3 -induced protection against stress-induced @entity1 may be due to its ability to suppress gastric acid secretion and to increase gastric mucus secretion. Its enhancement of @entity2 -induced @entity1 may be due to its ability to increase lipid peroxidation. The @entity6 -induced enhancement of the experimentally-induced @entity1 may be due to its ability to suppress gastric mucus secretion.

title: Effect of (+/-)- @entity3 and @entity6 on stress- and chemically-induced XXXX in @entity0 .

answer: @entity5


abstract: The influence of (+/-)- @entity3 and @entity6 on stress- and various chemically-induced @entity5 in @entity0 together with their influence on various biochemical parameters which affect the development of the induced @entity1 was examined. Pretreatment of @entity0 with (+/-)- @entity3 (4-16 mg kg-1 orally) significantly decreased cold-stress-induced @entity5 and enhanced @entity2 -induced @entity1 . It did not affect @entity8 - (30 mg kg-1 orally) or @entity7 - (5 mg kg-1 i.p.) induced @entity1 . Pretreatment of the animals with @entity6 (1-10 mg kg-1 orally) significantly enhanced @entity2 -, @entity7 - and cold-stress-induced @entity1 . It did not affect @entity8 -induced @entity1 . Pretreatment of the animals with @entity3 increased gastric mucus secretion, inhibited gastric acid secretion, decreased @entity4 content and enhanced gastric lipid peroxidation whereas pretreatment of the animals with @entity6 significantly decreased gastric mucus secretion. @entity6 did not affect gastric acid secretion, @entity4 or gastric lipid peroxidation. The results of this study suggest that @entity3 -induced protection against stress-induced @entity1 may be due to its ability to suppress gastric acid secretion and to increase gastric mucus secretion. Its enhancement of @entity2 -induced @entity1 may be due to its ability to increase lipid peroxidation. The @entity6 -induced enhancement of the experimentally-induced @entity1 may be due to its ability to suppress gastric mucus secretion.

title: Effect of (+/-)- @entity3 and @entity6 on stress- and chemically-induced @entity5 in XXXX .

answer: @entity0


abstract: @entity11 ( @entity13 ) shows unique clinico-pathological and biological features. @entity13 responds well to @entity15 analogues but relapses are frequent and novel therapies are required. @entity2 - @entity14 is the key driver mutation in @entity13 and distinguishes it from other @entity4 , including @entity1 ( @entity13 -variant and @entity3 ). The kinase-activating @entity2 - @entity14 mutation also represents an ideal therapeutic target in @entity13 . Here, we investigated the biological and therapeutic importance of the activated @entity2 - @entity12 - @entity6 pathway in @entity13 by exposing in vitro primary leukemic cells purified from 26 @entity0 to clinically available @entity2 ( @entity8 ; @entity9 ) or @entity12 ( @entity10 ) inhibitors. Results were validated in vivo in samples from @entity8 -treated @entity13 @entity0 within a phase-2 clinical trial. @entity2 and @entity12 inhibitors caused, specifically in @entity13 (but not @entity13 ) cells, marked @entity12 / @entity6 dephosphorylation, silencing of the @entity2 - @entity12 - @entity6 pathway transcriptional output, loss of the @entity13 -specific gene expression signature, downregulation of the @entity13 markers @entity5 , TRAP and @entity7 , smoothening of leukemic cells' hairy surface, and, eventually, apoptosis. Apoptosis was partially blunted by co-culture with bone marrow stromal cells antagonizing @entity12 - @entity6 dephosphorylation. This protective effect could be counteracted by combined @entity2 and @entity12 inhibition. Our results strongly support and inform the clinical use of @entity2 and @entity12 inhibitors in @entity13 .

title: XXXX inhibitors reverse the unique molecular signature and phenotype of @entity11 and exert potent anti-leukemic activity.

answer: @entity2


abstract: @entity11 ( @entity13 ) shows unique clinico-pathological and biological features. @entity13 responds well to @entity15 analogues but relapses are frequent and novel therapies are required. @entity2 - @entity14 is the key driver mutation in @entity13 and distinguishes it from other @entity4 , including @entity1 ( @entity13 -variant and @entity3 ). The kinase-activating @entity2 - @entity14 mutation also represents an ideal therapeutic target in @entity13 . Here, we investigated the biological and therapeutic importance of the activated @entity2 - @entity12 - @entity6 pathway in @entity13 by exposing in vitro primary leukemic cells purified from 26 @entity0 to clinically available @entity2 ( @entity8 ; @entity9 ) or @entity12 ( @entity10 ) inhibitors. Results were validated in vivo in samples from @entity8 -treated @entity13 @entity0 within a phase-2 clinical trial. @entity2 and @entity12 inhibitors caused, specifically in @entity13 (but not @entity13 ) cells, marked @entity12 / @entity6 dephosphorylation, silencing of the @entity2 - @entity12 - @entity6 pathway transcriptional output, loss of the @entity13 -specific gene expression signature, downregulation of the @entity13 markers @entity5 , TRAP and @entity7 , smoothening of leukemic cells' hairy surface, and, eventually, apoptosis. Apoptosis was partially blunted by co-culture with bone marrow stromal cells antagonizing @entity12 - @entity6 dephosphorylation. This protective effect could be counteracted by combined @entity2 and @entity12 inhibition. Our results strongly support and inform the clinical use of @entity2 and @entity12 inhibitors in @entity13 .

title: @entity2 inhibitors reverse the unique molecular signature and phenotype of XXXX and exert potent anti-leukemic activity.

answer: @entity11


abstract: The extracellular matrix of the developing vasculature varies in composition as a function of time and position. Cellular models of vascular biology and pathology depend on the assumption that stable phenotypic characteristics of vascular cells can be propagated through several generations of in vitro cultivation. We show that the positional and developmental heterogeneity of matrix phenotypes in the porcine aorta are expressed by explanted vascular @entity2 ( @entity2 ) and adventitial cell populations for a limited number of passages. @entity3 was expressed most highly by thoracic @entity2 while interstitial collagen production was usually maximal in abdominal segments. Parallel gradients of collagen types I, III and V, detected by specific ELISA assays, were expressed in early-passage @entity2 . Adventitial cell populations from the abdominal aorta of the neonatal @entity0 accumulated significant levels of collagen, while these fibroblasts produced less than 10% of the @entity3 made by @entity2 . All cell populations expressed alpha-smooth muscle actin in vitro. Gradients of collagen and @entity3 expression were evident for no more than three passages, and direct outgrowth of cells without limited digestion of the matrix further reduced phenotypic stability. Variation and decline of the @entity3 phenotype could be due to hypermethylation of regulatory sequences in the @entity3 gene or trans-acting factors, but @entity3 production was dose-dependently stimulated to a similar extent (100%; 10 microM @entity1 ) in all segmental @entity2 populations at early (p1) and late (p3) passage. These data indicated that faithful reflection of in vivo @entity2 behavior was limited to a few population doublings, at least under standard culture conditions. Modification of the cellular environment by reducing serum factors, changing matrix, or adding mechanical stimulation may increase phenotypic stability.

title: Phenotypic stability and variation in cells of the porcine aorta: collagen and XXXX production.

answer: @entity3


abstract: The use of adsorbents for the treatment of @entity0 suffering from various @entity2 is still in its infancy. Therefore, the development of selective absorbents for the removal or decrease of immunoproteins from plasma is of great importance. In this study, chitosan, a natural polysaccharide having structural characteristics similar to glycosamino glycans, which is non-toxic and biocompatible, has been used for protein adsorption studies. @entity4 like @entity1 and @entity6 in different ratios are bonded to these polymers to observe immunoadsorption. Several layers of @entity1 or @entity6 have been coated covalently on chitosan beads using N2-plasma, @entity8 or @entity7 treatments. Scanning electron micrographs have revealed the surface morphological changes after such modifications. The surface modified chitosan beads have exhibited high binding affinity for gamma-globulin compared to bare beads. It is also observed that the amount of @entity5 adsorption is reduced on modified substrate. A selective removal of IgG and IgM has also been observed with these modified matrix when tested with @entity0 plasma, using immuno diffusion methods. The modified chitosan membranes have demonstrated a @entity3 , showing that these substrates have become more blood compatible. Hence, it appears that modified chitosan surfaces may be an excellent sorbent system for haemoperfusion due to their high binding affinity for immunoproteins and blood compatibility. Further studies are needed to determine the behaviour under clinical conditions.

title: XXXX , @entity6 immobilized chitosan beads as adsorbents for selective removal of immunoproteins.

answer: @entity1


abstract: The use of adsorbents for the treatment of @entity0 suffering from various @entity2 is still in its infancy. Therefore, the development of selective absorbents for the removal or decrease of immunoproteins from plasma is of great importance. In this study, chitosan, a natural polysaccharide having structural characteristics similar to glycosamino glycans, which is non-toxic and biocompatible, has been used for protein adsorption studies. @entity4 like @entity1 and @entity6 in different ratios are bonded to these polymers to observe immunoadsorption. Several layers of @entity1 or @entity6 have been coated covalently on chitosan beads using N2-plasma, @entity8 or @entity7 treatments. Scanning electron micrographs have revealed the surface morphological changes after such modifications. The surface modified chitosan beads have exhibited high binding affinity for gamma-globulin compared to bare beads. It is also observed that the amount of @entity5 adsorption is reduced on modified substrate. A selective removal of IgG and IgM has also been observed with these modified matrix when tested with @entity0 plasma, using immuno diffusion methods. The modified chitosan membranes have demonstrated a @entity3 , showing that these substrates have become more blood compatible. Hence, it appears that modified chitosan surfaces may be an excellent sorbent system for haemoperfusion due to their high binding affinity for immunoproteins and blood compatibility. Further studies are needed to determine the behaviour under clinical conditions.

title: @entity1 , XXXX immobilized chitosan beads as adsorbents for selective removal of immunoproteins.

answer: @entity6


abstract: PURPOSE: We determined if the USPSTF recommendation against @entity3 screening was associated with a change in biopsy and @entity1 detection rates. MATERIALS AND METHODS: We conducted a time series analysis (October 2008 to  June 2013) of prostate biopsies performed at University Health Network (Toronto). Biopsies for active surveillance or solely targeting magnetic resonance imaging detected lesions were excluded from study. Interventional ARIMA models  with step functions were used to examine changes in the number of biopsies performed and @entity1 detected per month. @entity2 was defined as no Gleason pattern 4 or greater, 3 or fewer cores involved, or 1/3 or less of the total number of cores involved, and no core with greater than 50% @entity1 involvement. Intermediate to high grade @entity2 was defined as Gleason 7-10. RESULTS: A total of 3,408 biopsies were performed and 1,601 (47.0%) @entity2 were detected (low risk @entity2 563 [16.5%], intermediate to high  grade @entity2 914 [26.8%]). The median number of biopsies per month decreased from 58.0 (IQR 54.5-63.0) before the recommendations to 35.5  (IQR 27.0-41.0) afterward (p=0.003), while the median number of @entity0 undergoing first-time biopsy decreased from 42.5 (IQR 37.5-45.5) to 24.0 (IQR 19.0-32.5, p=0.025). The median number of @entity2 detected per month decreased from 8.5 (IQR 6.5-10.5) to 5.5 (IQR 4.0-7.0, p=0.012), while the median number of intermediate to high @entity2 per month decreased from 17.5 (IQR 14.5-21.5) to 10.0 (IQR 9.0-12.0, p <0.001). CONCLUSIONS: After the USPSTF recommendation the number of biopsies performed (total and first-time), based on referrals from our catchment area, has decreased. This is likely due to decreased use of @entity3 screening. Although it is encouraging that fewer @entity2 are being diagnosed, the sudden decrease in the detection rate of @entity2 is concerning.

title: Impact of the U.S. Preventive Services Task Force Recommendations against XXXX Screening on Prostate Biopsy and Cancer Detection Rates.

answer: @entity3


abstract: Objective To investigate the biological and molecular characteristics of @entity0 amniotic epithelial cells (HAECs) cultured in vitro. Methods HAECs were isolated by enzyme digestion from amnion after cesarean section. The growth of the cells was observed under an inverted microscope and the curve of cell growth was measured by CCK-8 assay. The @entity9 was observed by Giemsa staining. Flow cytometry was used to detect cell cycle distribution and analyze the expressions of @entity4 , @entity3 , @entity2 , @entity1 , CD105, @entity6 , @entity10 , HLA-DR in the second passage of HAECs. The expressions of @entity13 , @entity12 , @entity14 ( @entity14 ), stage-specific embryonic antigen-4 (SSEA-4), @entity8 protein ( @entity8 ), @entity11 , @entity5 , @entity7 ( @entity7 ) were identified by immunofluorescence staining. Results Pure HAECs could be obtained by enzymatic isolation method. The cells grew with adherence and polygonal shape. They entered exponential growth stage from the third day of adherence. The analysis of cell cycle distribution revealed that 66% of the cells were in G0/G1 phase, 31.69% in S phase and 2.31% in G2/M phase. In addition, the colony forming rate of HAECs was (9.33  2.00) %. Flow cytometry and immunofluorescence staining showed that the expressions of @entity2 , @entity4 , CD105, @entity1 , @entity13 , @entity12 , @entity14 , SSEA-4, @entity8 , @entity11 , @entity5 , @entity7 were positive. However, the expressions of @entity3 , @entity6 , @entity10 , HLA-DR were negative. Conclusion HAECs can be cultured and have proliferation ability for some time in vitro; HAECs express some embryonic stem cell-associated surface molecules.

title: [In vitro culture and molecular characterization of XXXX amniotic epithelial cells].

answer: @entity0


abstract: BACKGROUND: Altered plasma lipids, oxidative stress, and @entity0 have been involved in the pathogenesis of @entity1 . Fish oil has shown inconclusive effects on plasma lipids and oxidative stress. Spirulina has both @entity2 lowering and antioxidant properties. However, the effect of fish oil and spirulina on @entity4 has not been studied. We investigated the effects of fish oil, spirulina, and their combination on @entity4 . METHODS: The hamsters were divided into 7 groups: control, high @entity2 (HF), fish oil (post FO), spirulina (post SP), and a combination of fish oil and spirulina (post SF, pre-SF, and HF   +   SF) groups. The HF and HF   +   SF groups were given a high @entity2 diet for 8  weeks. The post FO, post SP, and post SF groups were given a high @entity2 diet for 4  weeks and then the treatment for 4  weeks. The pre-SF group was given the combined treatment for 4  weeks and then a high @entity2 diet for 4  weeks. RESULTS: The HF and HF   +   SF groups altered plasma lipids, increased oxidative stress, inhibited antioxidants, and increased @entity0 . While the post FO group increased plasma lipids and was more atherogenic. The vice versa was observed in spirulina-treated group. Both the post SP and post SF groups inhibited oxidative stress and increased antioxidant status, and post FO and post SP diets regulated pro-inflammatory cytokines to near the control levels. CONCLUSIONS: Both single treatment of fish oil or spirulina inhibit oxidative stress and @entity0 . Treatment with a combination of fish oil and spirulina (post SF) may be beneficial for diet-induced @entity3 hamsters.

title: Effects of fish oil and spirulina on oxidative stress and @entity0 in XXXX hamsters.

answer: @entity3


abstract: BACKGROUND: Altered plasma lipids, oxidative stress, and @entity0 have been involved in the pathogenesis of @entity1 . Fish oil has shown inconclusive effects on plasma lipids and oxidative stress. Spirulina has both @entity2 lowering and antioxidant properties. However, the effect of fish oil and spirulina on @entity4 has not been studied. We investigated the effects of fish oil, spirulina, and their combination on @entity4 . METHODS: The hamsters were divided into 7 groups: control, high @entity2 (HF), fish oil (post FO), spirulina (post SP), and a combination of fish oil and spirulina (post SF, pre-SF, and HF   +   SF) groups. The HF and HF   +   SF groups were given a high @entity2 diet for 8  weeks. The post FO, post SP, and post SF groups were given a high @entity2 diet for 4  weeks and then the treatment for 4  weeks. The pre-SF group was given the combined treatment for 4  weeks and then a high @entity2 diet for 4  weeks. RESULTS: The HF and HF   +   SF groups altered plasma lipids, increased oxidative stress, inhibited antioxidants, and increased @entity0 . While the post FO group increased plasma lipids and was more atherogenic. The vice versa was observed in spirulina-treated group. Both the post SP and post SF groups inhibited oxidative stress and increased antioxidant status, and post FO and post SP diets regulated pro-inflammatory cytokines to near the control levels. CONCLUSIONS: Both single treatment of fish oil or spirulina inhibit oxidative stress and @entity0 . Treatment with a combination of fish oil and spirulina (post SF) may be beneficial for diet-induced @entity3 hamsters.

title: Effects of fish oil and spirulina on oxidative stress and XXXX in @entity3 hamsters.

answer: @entity0


abstract: Increasing prevalence of @entity1 and its complications in the developing communities would pose a threat in respect to their existing health care service. An increased incidence of @entity4 in insulin-dependent @entity1 @entity0 has long been recognized. Hyperlipidaemia, a common finding in these @entity0 , may be one of the contributing factors. The objective of our study is to find out the patterns of dyslipidaemia among the Bangladeshi @entity0 with @entity1 presented with @entity5 . This study was conducted in the department of cardiology of BIRDEM and Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of January 2009 to December 2009. A total of 100 @entity0 were included in this study, according to the inclusion and exclusion criteria. @entity1 and @entity5 was diagnosed according to the guideline of American @entity1 Association and American College of Cardiology respectively. Among the respondents Mean  SD of fasting blood sugar and 2 hours ABF were 9.23  3.6mmol/L and 12.61  8.52mmol/L respectively. Mean  SD of HbA1C of the respondents was 7.23  2.12. Total @entity2 level <150mg/dl, 150-200mg/dl and >200mg/dl were 27.0%, 42.0% and 31.0% respectively. HDL @entity2 <40mg/dl and >40mg/dl were 76.0% and 24.0% respectively. LDL @entity2 <150mg/dl and >150mg/dl were 43.0% and 57.0% respectively. TG within 40 to 160mg/dl and >160mg/dl were 73.0% and 27.0% respectively, Mean  SD of Total @entity2 , HDL @entity2 , LDL @entity2 and @entity3 were 162.43  38.62, 37.41  8.59, 137.43  22.73 and 156.43  41.92mg/dl respectively.

title: Pattern of Dyslipidaemia among the Bangladeshi Type 2 XXXX @entity0 Presented With @entity5 .

answer: @entity1


abstract: Increasing prevalence of @entity1 and its complications in the developing communities would pose a threat in respect to their existing health care service. An increased incidence of @entity4 in insulin-dependent @entity1 @entity0 has long been recognized. Hyperlipidaemia, a common finding in these @entity0 , may be one of the contributing factors. The objective of our study is to find out the patterns of dyslipidaemia among the Bangladeshi @entity0 with @entity1 presented with @entity5 . This study was conducted in the department of cardiology of BIRDEM and Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of January 2009 to December 2009. A total of 100 @entity0 were included in this study, according to the inclusion and exclusion criteria. @entity1 and @entity5 was diagnosed according to the guideline of American @entity1 Association and American College of Cardiology respectively. Among the respondents Mean  SD of fasting blood sugar and 2 hours ABF were 9.23  3.6mmol/L and 12.61  8.52mmol/L respectively. Mean  SD of HbA1C of the respondents was 7.23  2.12. Total @entity2 level <150mg/dl, 150-200mg/dl and >200mg/dl were 27.0%, 42.0% and 31.0% respectively. HDL @entity2 <40mg/dl and >40mg/dl were 76.0% and 24.0% respectively. LDL @entity2 <150mg/dl and >150mg/dl were 43.0% and 57.0% respectively. TG within 40 to 160mg/dl and >160mg/dl were 73.0% and 27.0% respectively, Mean  SD of Total @entity2 , HDL @entity2 , LDL @entity2 and @entity3 were 162.43  38.62, 37.41  8.59, 137.43  22.73 and 156.43  41.92mg/dl respectively.

title: Pattern of Dyslipidaemia among the Bangladeshi Type 2 @entity1 @entity0 Presented With XXXX .

answer: @entity5


abstract: Increasing prevalence of @entity1 and its complications in the developing communities would pose a threat in respect to their existing health care service. An increased incidence of @entity4 in insulin-dependent @entity1 @entity0 has long been recognized. Hyperlipidaemia, a common finding in these @entity0 , may be one of the contributing factors. The objective of our study is to find out the patterns of dyslipidaemia among the Bangladeshi @entity0 with @entity1 presented with @entity5 . This study was conducted in the department of cardiology of BIRDEM and Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of January 2009 to December 2009. A total of 100 @entity0 were included in this study, according to the inclusion and exclusion criteria. @entity1 and @entity5 was diagnosed according to the guideline of American @entity1 Association and American College of Cardiology respectively. Among the respondents Mean  SD of fasting blood sugar and 2 hours ABF were 9.23  3.6mmol/L and 12.61  8.52mmol/L respectively. Mean  SD of HbA1C of the respondents was 7.23  2.12. Total @entity2 level <150mg/dl, 150-200mg/dl and >200mg/dl were 27.0%, 42.0% and 31.0% respectively. HDL @entity2 <40mg/dl and >40mg/dl were 76.0% and 24.0% respectively. LDL @entity2 <150mg/dl and >150mg/dl were 43.0% and 57.0% respectively. TG within 40 to 160mg/dl and >160mg/dl were 73.0% and 27.0% respectively, Mean  SD of Total @entity2 , HDL @entity2 , LDL @entity2 and @entity3 were 162.43  38.62, 37.41  8.59, 137.43  22.73 and 156.43  41.92mg/dl respectively.

title: Pattern of Dyslipidaemia among the Bangladeshi Type 2 @entity1 XXXX Presented With @entity5 .

answer: @entity0