abstract: AIM: To report a @entity0 with @entity2 who suffered from acute retinal ischemic change and @entity4 after intravitreal injection of bevacizumab. METHODS: A 55-year-old @entity0 had @entity2 with unilateral rubeosis and macular @entity1 . Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed @entity9 . A complete ocular examination, @entity7 angiography, carotid artery Doppler sonography and brain magnetic resonance imaging were performed. RESULTS: Best corrected visual acuity before injection was 6/60 in the left eye. He had underlying @entity6 combined with bilateral preproliferative @entity2 . Three days after intravitreal injection of bevacizumab, acute @entity3 occurred. He also suffered from @entity4 , and brain magnetic resonance angiography showed @entity5 . The final visual acuity was no light perception in the left eye and 3/6 in the right eye. CONCLUSIONS: @entity0 receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as @entity10 , @entity8 and poorly controlled @entity2 . Acute @entity3 change may be associated with intravitreal injection of bevacizumab in @entity0 with vascular compromised @entity2 and/or underlying stenosis of the carotid artery.

title: Acute @entity9 after intravitreal injection of bevacizumab (avastin) associated with XXXX .

answer: @entity3


abstract: AIM: To report a @entity0 with @entity2 who suffered from acute retinal ischemic change and @entity4 after intravitreal injection of bevacizumab. METHODS: A 55-year-old @entity0 had @entity2 with unilateral rubeosis and macular @entity1 . Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed @entity9 . A complete ocular examination, @entity7 angiography, carotid artery Doppler sonography and brain magnetic resonance imaging were performed. RESULTS: Best corrected visual acuity before injection was 6/60 in the left eye. He had underlying @entity6 combined with bilateral preproliferative @entity2 . Three days after intravitreal injection of bevacizumab, acute @entity3 occurred. He also suffered from @entity4 , and brain magnetic resonance angiography showed @entity5 . The final visual acuity was no light perception in the left eye and 3/6 in the right eye. CONCLUSIONS: @entity0 receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as @entity10 , @entity8 and poorly controlled @entity2 . Acute @entity3 change may be associated with intravitreal injection of bevacizumab in @entity0 with vascular compromised @entity2 and/or underlying stenosis of the carotid artery.

title: Acute XXXX after intravitreal injection of bevacizumab (avastin) associated with @entity3 .

answer: @entity9


abstract: OBJECTIVE: Laparoscopic myotomy is the preferred treatment of @entity2 . Our objectives were to assess the long-term outcome of esophageal myotomy and to identify preoperative factors influencing the outcome. METHODS: Preoperative and long-term outcome data were collected from @entity0 undergoing laparoscopic myotomy for @entity2 at our institution. The primary endpoint of the study was the postoperative change (delta) in @entity1 score. This score was calculated by combining the frequency and the severity of @entity1 . Persistent postoperative @entity1 was defined as 1 standard deviation less than the mean delta score of all @entity0 . Logistic regression was used to identify independent preoperative factors associated with successful myotomy. RESULTS: A total of 200 consecutive @entity0 were included in the study. At a mean follow-up of 42.1 months, the mean delta @entity1 score was 7.1 +/- 2.6; therefore, the myotomy was considered successful when the delta score was >4.5. According to this definition, 170 (85%) @entity0 achieved excellent @entity1 relief (responders). Responders had higher preoperative low esophageal sphincter (LES) pressure than nonresponders: 42.6 +/- 13.1 versus 23.8 +/- 7.0 mm Hg (P = 0.001). High preoperative LES pressure remained an independent predictor of excellent response in the multivariate logistic regression model. @entity0 with LES pressure >35 mm Hg had an odds ratio of 21.3, making more likely to achieve excellent @entity1 relief after myotomy compared with those with LES pressure < or =35 mm Hg (odds ratio, 21.3; 95% confidence interval, 6.1-73.5, P = 0.0001). CONCLUSION: Laparoscopic myotomy can durably relieve symptoms of @entity1 . Elevated preoperative LES pressure represents the strongest positive outcome predictor.

title: Laparoscopic myotomy for XXXX : predictors of successful outcome after 200 cases.

answer: @entity2


abstract: PURPOSE: This study was designed to report the long-term complications of iris-claw phakic intraocular lens implantation in a @entity0 with @entity12 . METHODS: Case report and literature review. RESULTS: A 26-year-old @entity0 with a history of @entity3 had bilateral phakic lens implantation for @entity6 10 years previously. Two years later, the left implant dislocated and was repositioned. Slit-lamp examination of both eyes revealed phakic implants of the iris-claw variety. There were moderate @entity10 in the areas in which the lens haptics pinched the @entity5 and moderate epithelial and stromal @entity1 over the temporal one-third of the left @entity2 . The crystalline lenses were clear with 3+phacodonesis OU. Dilated fundus examinations revealed bilateral severe @entity7 . Crystalline lens diameters were measured at 7.5mm in the right eye and 8 mm in the left. Anterior chamber depths were 2.63 mm OD and 2.40 mm @entity9 . Specular microscopy revealed central endothelial cell counts of 1133 and 587 cells/mm OD and @entity9 , respectively. Axial lengths were 23.3 mm OD and 25 mm @entity9 . Gonioscopic examination revealed bilateral angle closure with marked @entity8 . Based on our findings of @entity4 , shortened and thickened fingers, relatively normal axial length, @entity11 , @entity6 , and @entity3 , we diagnosed the @entity0 with @entity12 . CONCLUSION: Iris claw-lens phakic lenses may be an effective surgical alternative to correct @entity6 in select @entity0 ; however, it may produce long-term complications in eyes with specific features.

title: Long-term complications of iris-claw phakic intraocular lens implantation in XXXX .

answer: @entity12


abstract: One of the unique features of beta-cells is their relatively low expression of many antioxidant enzymes. This could render beta-cells susceptible to oxidative damage but may also provide a system that is sensitive to reactive @entity2 species as signals. In isolated @entity1 islets and INS-1(832/13) cells, @entity5 increases intracellular accumulation of @entity4 . In both models, insulin secretion could be stimulated by provision of either exogenous @entity4 or @entity10 , which raises intracellular @entity4 levels. Provision of exogenous @entity4 scavengers, including cell permeable catalase and @entity6 , inhibited @entity5 -stimulated @entity4 accumulation and insulin secretion (GSIS). In contrast, cell permeable @entity3 dismutase, which metabolizes @entity3 into @entity4 , had no effect on GSIS. Because oxidative stress is an important risk factor for beta-cell dysfunction in @entity0 , the relationship between @entity5 -induced @entity4 generation and GSIS was investigated under various oxidative stress conditions. Acute exposure of isolated @entity1 islets or INS-1(832/13) cells to oxidative stressors, including @entity7 , @entity8 , and @entity9 , led to decreased GSIS. This impaired GSIS was associated with increases in a battery of endogenous antioxidant enzymes. Taken together, these findings suggest that @entity4 derived from @entity5 metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function.

title: Reactive XXXX species as a signal in @entity5 -stimulated insulin secretion.

answer: @entity2


abstract: One of the unique features of beta-cells is their relatively low expression of many antioxidant enzymes. This could render beta-cells susceptible to oxidative damage but may also provide a system that is sensitive to reactive @entity2 species as signals. In isolated @entity1 islets and INS-1(832/13) cells, @entity5 increases intracellular accumulation of @entity4 . In both models, insulin secretion could be stimulated by provision of either exogenous @entity4 or @entity10 , which raises intracellular @entity4 levels. Provision of exogenous @entity4 scavengers, including cell permeable catalase and @entity6 , inhibited @entity5 -stimulated @entity4 accumulation and insulin secretion (GSIS). In contrast, cell permeable @entity3 dismutase, which metabolizes @entity3 into @entity4 , had no effect on GSIS. Because oxidative stress is an important risk factor for beta-cell dysfunction in @entity0 , the relationship between @entity5 -induced @entity4 generation and GSIS was investigated under various oxidative stress conditions. Acute exposure of isolated @entity1 islets or INS-1(832/13) cells to oxidative stressors, including @entity7 , @entity8 , and @entity9 , led to decreased GSIS. This impaired GSIS was associated with increases in a battery of endogenous antioxidant enzymes. Taken together, these findings suggest that @entity4 derived from @entity5 metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function.

title: Reactive @entity2 species as a signal in XXXX -stimulated insulin secretion.

answer: @entity5


abstract: OBJECTIVES: Noninvasive objective tests are needed to diagnose @entity2 ( @entity2 ) and to evaluate treatment responses. Ultrasound imaging of the salivary glands is rapid and noninvasive. Recent open-label studies suggested that anti- @entity1 (rituximab) may be effective in @entity2 . The purpose of this study was to look for ultrasound evidence of the effects of rituximab in @entity2 . METHODS: We compared 16 @entity0 fulfilling the new American-European consensus group criteria for @entity2 to 9 controls, using B-mode ultrasound features (parenchymal homogeneity and gland size) and Doppler waveform analysis of the transverse facial artery of parotid glands. We compared the same parameters in the @entity0 before and after 12 weeks of intravenous rituximab therapy. RESULTS: Compared to controls, untreated @entity0 had significant abnormalities in salivary gland structure (p < 0.0001) and parotid size (2.05 +/- 0.33 cm versus 1.70 +/- 0.28 cm; p = 0.001). Doppler waveform analysis showed significant differences before, but not after, lemon stimulation between untreated @entity0 and controls. After rituximab treatment, significant size reductions were noted in the parotids (2.05 +/- 0.3 cm at baseline and 1.86 +/- 0.27 cm at week 12; p = 0.002) and submandibular glands (2.02 +/- 0.54 cm at baseline and 1.66 +/- 0.34 cm at week 12; p = 0.001). Doppler resistive indices after lemon stimulation were significantly increased after rituximab treatment. CONCLUSION: Salivary gland measurements and blood inflow responses to salivary stimulation as assessed by ultrasound hold promise as objective noninvasive tools for evaluating rituximab effects in @entity0 with @entity2 .

title: Ultrasound assessment of salivary glands in XXXX with primary Sj  gren's syndrome treated with rituximab: Quantitative and Doppler waveform analysis.

answer: @entity0


abstract: @entity11 are a new class of antimicrotubule agents currently in clinical trials. Their chemical structures are distinct from @entity7 and are more amenable to synthetic modification. Six @entity11 have been studied in preclinical and clinical trials: @entity8 ( @entity8 ), @entity10 ( @entity10 ), @entity13 , @entity9 (ZK-EPO), @entity12 ( @entity12 ), and @entity14 . In vitro data have shown increased potency in @entity6 -sensitive and @entity6 -resistant @entity1 cell lines. This enhanced cytotoxic effect has been attributed to epothilone being a poor substrate for @entity5 drug resistance protein and having high affinity to the various beta tubulin isoforms. Phase I clinical data have shown different dose-limiting @entity2 for each of the @entity11 . These effects are drug specific, dose specific, and schedule of administration specific. While @entity3 and myelosuppression are the dose-limiting @entity2 for @entity8 and @entity13 , respectively, @entity2 , as seen with @entity7 , is the dose-limiting @entity2 of @entity10 , @entity9 , and @entity12 . In an effort to decrease @entity2 , investigators have modified dosing schedules with limited success. @entity10 has the most mature clinical results with published phase II and III data, and regulatory approval for clinical use in the treatment of @entity0 . @entity10 has also been combined with other anticancer agents and has regulatory approval in combination with @entity4 for heavily treated @entity0 .

title: Novel microtubule-targeting agents - the XXXX .

answer: @entity11


abstract: PURPOSE OF THE STUDY: We reviewed cases of @entity5 or os acromiale among a consecutive series of 240 reverse prostheses implanted between 1995 and 2003. MATERIAL AND @entity0 : Ten @entity0 presented os acromiale, ten @entity3 , and one nonunion of the scapular spine. The reverse prosthesis was implanted via a deltopectoral approach with no specific procedure on the acromion. There were 17 @entity0 and four @entity0 , mean age 72 years. The dominant side was involved for 70%. The prosthesis was indicated for excentered @entity6 (n=14), massive rotator cuff tears without @entity4 (n=5), and failure of a hemiarthroplasty (n=2). Seventeen @entity0 were reviewed with more than two years follow-up. RESULTS: 87.5% of the acromial lesions became dislocated postoperatively due to the traction of the deltoid. There was no significant difference between os acromiale and @entity5 . The acromial displacement did not compromise the objective outcome since the Constant score was comparable to that obtained in 179 cases with no acromial lesion reviewed with the same follow-up. Unlike these later shoulders, there were two cases of scapular spine fracture postoperatively, leading to poor function ( @entity2 and motion scores less than the global score). CONCLUSION: Acquired or congenital acromial lesions are not a contraindication for reverse prosthesis. @entity1 of the scapular spine is less well tolerated and may required revision for osteosynthesis.

title: [Reverse prosthesis and os acromiale or XXXX ].

answer: @entity5


abstract: BACKGROUND: In the @entity1 complex, paracentric chromosomal inversions are non-randomly distributed along the complement: 18/31 (58%) of common polymorphic inversions are on chromosome arm 2R, which represents only approximately 30% of the complement. Moreover, in An. gambiae sensu stricto, 6/7 common polymorphic inversions occur on 2R. Most of these inversions are considered markers of ecological adaptation that increase the fitness of the carriers of alternative karyotypes in contrasting habitats. However, little is known about the evolutionary forces responsible for their origin and subsequent establishment in field populations. RESULTS: Here, we present data on 82 previously undescribed @entity2 ( @entity2 ) recorded during extensive field sampling in 16 African countries over a 30 year period, which may shed light on the dynamics of chromosomal plasticity in An. gambiae. We analyzed breakpoint distribution, length, and geographic distribution of @entity2 , and compared these measures to those of the common inversions. We found that @entity2 , like common inversions, are disproportionately clustered on 2R, which may indicate that this arm is especially prone to breakages. However, contrasting patterns were observed between the geographic distribution of common inversions and @entity2 . @entity2 were equally frequent across biomes and on both sides of the Great Rift Valley ( @entity3 ), whereas common inversions predominated in arid ecological settings and west of the @entity3 . Moreover, the distribution of RCI lengths followed a random pattern while common inversions were significantly less frequent at shorter lengths. CONCLUSION: Because 17/82 (21%) @entity2 were found repeatedly at very low frequencies - at the same sampling location in different years and/or in different sampling locations - we suggest that @entity2 are subject mainly to drift under unperturbed ecological conditions. Nevertheless, @entity2 may represent an important reservoir of genetic variation for An. gambiae in response to environmental changes, further testifying to the considerable evolutionary potential hidden within this pan-African @entity0 vector.

title: Chromosomal plasticity and evolutionary potential in the @entity0 vector XXXX : insights from three decades of rare paracentric inversions.

answer: @entity1


abstract: BACKGROUND: In the @entity1 complex, paracentric chromosomal inversions are non-randomly distributed along the complement: 18/31 (58%) of common polymorphic inversions are on chromosome arm 2R, which represents only approximately 30% of the complement. Moreover, in An. gambiae sensu stricto, 6/7 common polymorphic inversions occur on 2R. Most of these inversions are considered markers of ecological adaptation that increase the fitness of the carriers of alternative karyotypes in contrasting habitats. However, little is known about the evolutionary forces responsible for their origin and subsequent establishment in field populations. RESULTS: Here, we present data on 82 previously undescribed @entity2 ( @entity2 ) recorded during extensive field sampling in 16 African countries over a 30 year period, which may shed light on the dynamics of chromosomal plasticity in An. gambiae. We analyzed breakpoint distribution, length, and geographic distribution of @entity2 , and compared these measures to those of the common inversions. We found that @entity2 , like common inversions, are disproportionately clustered on 2R, which may indicate that this arm is especially prone to breakages. However, contrasting patterns were observed between the geographic distribution of common inversions and @entity2 . @entity2 were equally frequent across biomes and on both sides of the Great Rift Valley ( @entity3 ), whereas common inversions predominated in arid ecological settings and west of the @entity3 . Moreover, the distribution of RCI lengths followed a random pattern while common inversions were significantly less frequent at shorter lengths. CONCLUSION: Because 17/82 (21%) @entity2 were found repeatedly at very low frequencies - at the same sampling location in different years and/or in different sampling locations - we suggest that @entity2 are subject mainly to drift under unperturbed ecological conditions. Nevertheless, @entity2 may represent an important reservoir of genetic variation for An. gambiae in response to environmental changes, further testifying to the considerable evolutionary potential hidden within this pan-African @entity0 vector.

title: Chromosomal plasticity and evolutionary potential in the XXXX vector @entity1 : insights from three decades of rare paracentric inversions.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Atypical antipsychotics have been related with hyperglycaemia, @entity1 , @entity4 and lipid alterations in some @entity0 . This study analyzed whether continuous treatment with @entity7 , @entity5 , or @entity6 entails a risk of @entity3 or lipid metabolism alterations in @entity2 @entity0 . @entity0 AND METHOD: @entity0 included in this study were @entity2 who had received mono-therapeutic with @entity6 , @entity5 or @entity7 for a period of 1 to 3 years. Those @entity2 @entity0 who were diagnosed as @entity1 during psychiatric treatment and those who showed fasting glycemia greater than or equal to 126 mg/dl in two consecutive measurements were considered cases. The remaining @entity2 @entity0 who were receiving treatment and did not show these alterations were considered controls. RESULTS: In the adjusted analysis (multivariate logistic regression) of the effect of antipsychotic treatment on the presence of @entity1 , which also assessed age and body-mass index, the adjusted odds ratio (OR) for @entity5 relative to @entity7 was 2.22 (95% confidence interval [CI], 1.12-4.22), (p = 0.0228); and that for @entity6 relative to @entity7 was 2.87 (95% CI, 1.19, 6.93), (p = 0.0192). Both results reveal a significantly greater risk for the appearance of @entity1 in @entity0 treated with @entity5 or @entity6 than in those treated with @entity7 . There were significant differences in the risk of increase in @entity8 in @entity0 receiving @entity5 (OR = 1.34; p = 0.0075) and @entity6 (OR = 1.58; p = 0.0028). CONCLUSIONS: The risk of the appearance of @entity1 in @entity0 treated with @entity5 is twice as high as that in @entity0 treated with @entity7 , and the risk in @entity0 treated with @entity6 is nearly triple as high as that found in @entity0 treated with @entity7 . @entity7 appears to be a safer antipsychotic drug in the long term, with regard to the risk of alterations in @entity3 and lipid metabolism.

title: [Therapy with antipsychotic drugs as a risk factor for @entity1 in XXXX : a case-control study].

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: Atypical antipsychotics have been related with hyperglycaemia, @entity1 , @entity4 and lipid alterations in some @entity0 . This study analyzed whether continuous treatment with @entity7 , @entity5 , or @entity6 entails a risk of @entity3 or lipid metabolism alterations in @entity2 @entity0 . @entity0 AND METHOD: @entity0 included in this study were @entity2 who had received mono-therapeutic with @entity6 , @entity5 or @entity7 for a period of 1 to 3 years. Those @entity2 @entity0 who were diagnosed as @entity1 during psychiatric treatment and those who showed fasting glycemia greater than or equal to 126 mg/dl in two consecutive measurements were considered cases. The remaining @entity2 @entity0 who were receiving treatment and did not show these alterations were considered controls. RESULTS: In the adjusted analysis (multivariate logistic regression) of the effect of antipsychotic treatment on the presence of @entity1 , which also assessed age and body-mass index, the adjusted odds ratio (OR) for @entity5 relative to @entity7 was 2.22 (95% confidence interval [CI], 1.12-4.22), (p = 0.0228); and that for @entity6 relative to @entity7 was 2.87 (95% CI, 1.19, 6.93), (p = 0.0192). Both results reveal a significantly greater risk for the appearance of @entity1 in @entity0 treated with @entity5 or @entity6 than in those treated with @entity7 . There were significant differences in the risk of increase in @entity8 in @entity0 receiving @entity5 (OR = 1.34; p = 0.0075) and @entity6 (OR = 1.58; p = 0.0028). CONCLUSIONS: The risk of the appearance of @entity1 in @entity0 treated with @entity5 is twice as high as that in @entity0 treated with @entity7 , and the risk in @entity0 treated with @entity6 is nearly triple as high as that found in @entity0 treated with @entity7 . @entity7 appears to be a safer antipsychotic drug in the long term, with regard to the risk of alterations in @entity3 and lipid metabolism.

title: [Therapy with antipsychotic drugs as a risk factor for XXXX in @entity2 : a case-control study].

answer: @entity1


abstract: BACKGROUND _ OBJECTIVE: Recent studies suggest strong therapeutic potentials of @entity4 ( @entity6 ) for @entity3 (MM), which may be due to @entity6 -induced demethylation of @entity1 suppressor genes. This study was to explore the correlation of cell cycle alteration to @entity5 gene demethylation after @entity6 induction in MM cell lines in vitro. METHODS: MM cell lines @entity0 and RPMI8226 were used. Cell proliferation and cell cycle of MM cells after the treatment of @entity6 were assessed by @entity2 assay and flow cytometry, respectively. Methylation status was detected by methylation specific PCR (MSP-PCR), and gene expression of @entity5 was measured by real-time PCR in MM cells before and after @entity6 treatment. RESULTS: @entity6 significantly inhibited the growth of @entity0 and RPMI8226 cells in a dose-dependent manner. The cell cycle of U266 and RPMI8226 were arrested at G0/G1 phase. Compared with the wild type, the percentage of cells was increased at G0-G1 phase, but decreased at S phase after the treatment of @entity6 for 72 h (P < 0.05). The mRNA expression of @entity5 gene was significantly increased with hemi-methylation ( @entity6 , 0.5 micromol/L,72 h) or complete demethylation ( @entity6 , 1.0 micromol/L or @entity6 , 2.0 micromol/L,72 h) of the @entity5 gene in comparison with the wide type (P<0.05). CONCLUSIONS: @entity6 could induce cell cycle alteration of MM, which might be related to demethylation and reexpression of @entity5 gene in MM cell lines. The study might provide a new approach to elucidate the mechanism of the antitumor effect of @entity6 in MM.

title: [Correlation of cell cycle alteration to @entity5 gene demethylation induced by XXXX in @entity3 cell lines].

answer: @entity4


abstract: BACKGROUND _ OBJECTIVE: Recent studies suggest strong therapeutic potentials of @entity4 ( @entity6 ) for @entity3 (MM), which may be due to @entity6 -induced demethylation of @entity1 suppressor genes. This study was to explore the correlation of cell cycle alteration to @entity5 gene demethylation after @entity6 induction in MM cell lines in vitro. METHODS: MM cell lines @entity0 and RPMI8226 were used. Cell proliferation and cell cycle of MM cells after the treatment of @entity6 were assessed by @entity2 assay and flow cytometry, respectively. Methylation status was detected by methylation specific PCR (MSP-PCR), and gene expression of @entity5 was measured by real-time PCR in MM cells before and after @entity6 treatment. RESULTS: @entity6 significantly inhibited the growth of @entity0 and RPMI8226 cells in a dose-dependent manner. The cell cycle of U266 and RPMI8226 were arrested at G0/G1 phase. Compared with the wild type, the percentage of cells was increased at G0-G1 phase, but decreased at S phase after the treatment of @entity6 for 72 h (P < 0.05). The mRNA expression of @entity5 gene was significantly increased with hemi-methylation ( @entity6 , 0.5 micromol/L,72 h) or complete demethylation ( @entity6 , 1.0 micromol/L or @entity6 , 2.0 micromol/L,72 h) of the @entity5 gene in comparison with the wide type (P<0.05). CONCLUSIONS: @entity6 could induce cell cycle alteration of MM, which might be related to demethylation and reexpression of @entity5 gene in MM cell lines. The study might provide a new approach to elucidate the mechanism of the antitumor effect of @entity6 in MM.

title: [Correlation of cell cycle alteration to XXXX gene demethylation induced by @entity4 in @entity3 cell lines].

answer: @entity5


abstract: BACKGROUND _ OBJECTIVE: Recent studies suggest strong therapeutic potentials of @entity4 ( @entity6 ) for @entity3 (MM), which may be due to @entity6 -induced demethylation of @entity1 suppressor genes. This study was to explore the correlation of cell cycle alteration to @entity5 gene demethylation after @entity6 induction in MM cell lines in vitro. METHODS: MM cell lines @entity0 and RPMI8226 were used. Cell proliferation and cell cycle of MM cells after the treatment of @entity6 were assessed by @entity2 assay and flow cytometry, respectively. Methylation status was detected by methylation specific PCR (MSP-PCR), and gene expression of @entity5 was measured by real-time PCR in MM cells before and after @entity6 treatment. RESULTS: @entity6 significantly inhibited the growth of @entity0 and RPMI8226 cells in a dose-dependent manner. The cell cycle of U266 and RPMI8226 were arrested at G0/G1 phase. Compared with the wild type, the percentage of cells was increased at G0-G1 phase, but decreased at S phase after the treatment of @entity6 for 72 h (P < 0.05). The mRNA expression of @entity5 gene was significantly increased with hemi-methylation ( @entity6 , 0.5 micromol/L,72 h) or complete demethylation ( @entity6 , 1.0 micromol/L or @entity6 , 2.0 micromol/L,72 h) of the @entity5 gene in comparison with the wide type (P<0.05). CONCLUSIONS: @entity6 could induce cell cycle alteration of MM, which might be related to demethylation and reexpression of @entity5 gene in MM cell lines. The study might provide a new approach to elucidate the mechanism of the antitumor effect of @entity6 in MM.

title: [Correlation of cell cycle alteration to @entity5 gene demethylation induced by @entity4 in XXXX cell lines].

answer: @entity3


abstract: OBJECTIVE: Psychotic symptoms (PS) in @entity1 ( @entity1 ) usually develop as a side effect of the dopaminergic therapy and consist of @entity4 and delusions. We observed that @entity1 @entity0 who developed delusions tend to be younger than those with @entity4 and we aimed to investigate the validity of this observation. METHODS: The medical records of 127 @entity1 @entity0 with PS were reviewed and 76 @entity0 who were on treatment with @entity3 agonists with or without levodopa at the time of developing PS were included. @entity0 were stratified into 3 groups according to the subtypes of PS: @entity0 with solely @entity4 (n = 46), solely delusions (n = 18), and both types (n = 12). The groups were compared with respect to the age-at-onset of @entity1 and PS, duration of @entity1 , Activities of Daily Living (ADL) and motor subscale scores of Unified @entity1 Rating Scale (UPDRS), and levodopa equivalent dose of the dopaminergic agents administered at the time of PS onset. RESULTS: The mean age-at onset of @entity1 and PS was significantly younger (p = 0.0001) in @entity0 with delusions (49 and 55.9 years) than those with @entity4 (61.9 and 68.9 years). The same parameters were also significantly different (p = 0.002 and p = 0.001, respectively) between the groups of @entity0 with concurrent delusions and @entity4 (51.7 and 57.2 years) and those with only @entity4 . ADL and motor subscale scores were higher in @entity0 with @entity4 (p = 0.016 and p = 0.013) compared with those noted in @entity0 with delusions despite similar disease duration. The mean levodopa equivalent doses of the dopaminergic agents administered at the time of onset of PS did not differ between the groups. CONCLUSION: This study supported an association of delusions with younger onset of both @entity1 and @entity2 as compared with @entity4 . However, additional factors related to this association remain to be elucidated.

title: Relationship between age and subtypes of XXXX in @entity1 .

answer: @entity2


abstract: OBJECTIVE: Psychotic symptoms (PS) in @entity1 ( @entity1 ) usually develop as a side effect of the dopaminergic therapy and consist of @entity4 and delusions. We observed that @entity1 @entity0 who developed delusions tend to be younger than those with @entity4 and we aimed to investigate the validity of this observation. METHODS: The medical records of 127 @entity1 @entity0 with PS were reviewed and 76 @entity0 who were on treatment with @entity3 agonists with or without levodopa at the time of developing PS were included. @entity0 were stratified into 3 groups according to the subtypes of PS: @entity0 with solely @entity4 (n = 46), solely delusions (n = 18), and both types (n = 12). The groups were compared with respect to the age-at-onset of @entity1 and PS, duration of @entity1 , Activities of Daily Living (ADL) and motor subscale scores of Unified @entity1 Rating Scale (UPDRS), and levodopa equivalent dose of the dopaminergic agents administered at the time of PS onset. RESULTS: The mean age-at onset of @entity1 and PS was significantly younger (p = 0.0001) in @entity0 with delusions (49 and 55.9 years) than those with @entity4 (61.9 and 68.9 years). The same parameters were also significantly different (p = 0.002 and p = 0.001, respectively) between the groups of @entity0 with concurrent delusions and @entity4 (51.7 and 57.2 years) and those with only @entity4 . ADL and motor subscale scores were higher in @entity0 with @entity4 (p = 0.016 and p = 0.013) compared with those noted in @entity0 with delusions despite similar disease duration. The mean levodopa equivalent doses of the dopaminergic agents administered at the time of onset of PS did not differ between the groups. CONCLUSION: This study supported an association of delusions with younger onset of both @entity1 and @entity2 as compared with @entity4 . However, additional factors related to this association remain to be elucidated.

title: Relationship between age and subtypes of @entity2 in XXXX .

answer: @entity1


abstract: BACKGROUND: The @entity4 are a very heterogeneous group of @entity7 . They include @entity2 , hemoglobin variants and @entity1 . @entity5 is the most common @entity0 in India. Molecular characterization of this disease has revealed an extremely heterogeneous picture. METHODS: 1592 blood samples from suspected cases were studied using high performance liquid chromatography, amplification refractory mutation system polymerase chain reaction and reverse dot blot techniques. RESULTS: Out of 1592 cases, we found 119 cases of @entity5 major, and 347 cases of @entity5 trait. In addition to this, cases with structural variants like @entity3 , sickle cell trait, @entity2 (Hb DD), @entity2 (Hb EE), double heterozygotes and the @entity1 were also found. Molecular analysis revealed the presence of different @entity5 mutations in the population under study. CONCLUSIONS: Molecular analysis revealed that @entity8 and 619 bp deletion are the most common mutations in the population under study. The knowledge about the frequency of predominant mutations in the present population helps in offering prenatal diagnosis to the families having @entity6 at risk.

title: XXXX in Andhra Pradesh, India: a population study.

answer: @entity0


abstract: Acute @entity6 in @entity7 (AMIMC) are thought to suggest the presence of cardioembolic sources or systemic hypercoagulopathy. However, the mechanism and the simultaneous occurrence of AMIMC are not well known. We reviewed 685 consecutive acute @entity4 @entity0 who underwent @entity3 ( @entity3 ) within 48 hours of onset. AMIMC was defined as multiple acute @entity3 lesions distributed in more than one cerebral circulation (i.e., 2 anterior and 1 posterior circulations). Signal intensities on apparent diffusion coefficient (ADC) maps corresponding to acute @entity3 lesions were classified as 'low', 'iso-' or 'high' signals. Blood markers obtained within 24 hours after admission were compared between @entity0 with and without AMIMC. Sixty-seven (9.8%) @entity0 had AMIMC. Frequency of cardioembolism in AMIMC @entity0 was only 29.9% (20/67), which was not different from non-AMIMC @entity0 (21.7%, p = 0.16). Large-artery @entity5 (LAA) or small-vessel occlusion (SVO) in multiple circulations or combined LAA and SVO were identified in 34.3% (23/ 67) of AMIMC @entity0 , although pure LAA and pure SVO were less frequent than in non-AMIMC @entity0 . ADC signals were purely 'low' in 38 (56.7%) and 'mixed' (low with iso- or high) in 29 (43.3%). Cardioembolism tended to be associated with 'low' ADC signals (75.0%) compared with other @entity2 mechanisms (48.9%; p = 0.062). @entity8 was higher in AMIMC than in non- AMIMC @entity0 (p = 0.009). @entity2 mechanisms responsible for AMIMC are heterogeneous. ADC findings suggest that AMIMC commonly occur stepwise and may be useful in determining @entity2 mechanism. Systemic @entity1 may be associated with the pathogenesis of AMIMC.

title: Mechanism of XXXX in @entity7 on @entity3 .

answer: @entity6


abstract: Acute @entity6 in @entity7 (AMIMC) are thought to suggest the presence of cardioembolic sources or systemic hypercoagulopathy. However, the mechanism and the simultaneous occurrence of AMIMC are not well known. We reviewed 685 consecutive acute @entity4 @entity0 who underwent @entity3 ( @entity3 ) within 48 hours of onset. AMIMC was defined as multiple acute @entity3 lesions distributed in more than one cerebral circulation (i.e., 2 anterior and 1 posterior circulations). Signal intensities on apparent diffusion coefficient (ADC) maps corresponding to acute @entity3 lesions were classified as 'low', 'iso-' or 'high' signals. Blood markers obtained within 24 hours after admission were compared between @entity0 with and without AMIMC. Sixty-seven (9.8%) @entity0 had AMIMC. Frequency of cardioembolism in AMIMC @entity0 was only 29.9% (20/67), which was not different from non-AMIMC @entity0 (21.7%, p = 0.16). Large-artery @entity5 (LAA) or small-vessel occlusion (SVO) in multiple circulations or combined LAA and SVO were identified in 34.3% (23/ 67) of AMIMC @entity0 , although pure LAA and pure SVO were less frequent than in non-AMIMC @entity0 . ADC signals were purely 'low' in 38 (56.7%) and 'mixed' (low with iso- or high) in 29 (43.3%). Cardioembolism tended to be associated with 'low' ADC signals (75.0%) compared with other @entity2 mechanisms (48.9%; p = 0.062). @entity8 was higher in AMIMC than in non- AMIMC @entity0 (p = 0.009). @entity2 mechanisms responsible for AMIMC are heterogeneous. ADC findings suggest that AMIMC commonly occur stepwise and may be useful in determining @entity2 mechanism. Systemic @entity1 may be associated with the pathogenesis of AMIMC.

title: Mechanism of @entity6 in XXXX on @entity3 .

answer: @entity7


abstract: Acute @entity6 in @entity7 (AMIMC) are thought to suggest the presence of cardioembolic sources or systemic hypercoagulopathy. However, the mechanism and the simultaneous occurrence of AMIMC are not well known. We reviewed 685 consecutive acute @entity4 @entity0 who underwent @entity3 ( @entity3 ) within 48 hours of onset. AMIMC was defined as multiple acute @entity3 lesions distributed in more than one cerebral circulation (i.e., 2 anterior and 1 posterior circulations). Signal intensities on apparent diffusion coefficient (ADC) maps corresponding to acute @entity3 lesions were classified as 'low', 'iso-' or 'high' signals. Blood markers obtained within 24 hours after admission were compared between @entity0 with and without AMIMC. Sixty-seven (9.8%) @entity0 had AMIMC. Frequency of cardioembolism in AMIMC @entity0 was only 29.9% (20/67), which was not different from non-AMIMC @entity0 (21.7%, p = 0.16). Large-artery @entity5 (LAA) or small-vessel occlusion (SVO) in multiple circulations or combined LAA and SVO were identified in 34.3% (23/ 67) of AMIMC @entity0 , although pure LAA and pure SVO were less frequent than in non-AMIMC @entity0 . ADC signals were purely 'low' in 38 (56.7%) and 'mixed' (low with iso- or high) in 29 (43.3%). Cardioembolism tended to be associated with 'low' ADC signals (75.0%) compared with other @entity2 mechanisms (48.9%; p = 0.062). @entity8 was higher in AMIMC than in non- AMIMC @entity0 (p = 0.009). @entity2 mechanisms responsible for AMIMC are heterogeneous. ADC findings suggest that AMIMC commonly occur stepwise and may be useful in determining @entity2 mechanism. Systemic @entity1 may be associated with the pathogenesis of AMIMC.

title: Mechanism of @entity6 in @entity7 on XXXX .

answer: @entity3


abstract: BACKGROUND: Treatment of @entity3 ( @entity4 ) has changed in many aspects. A more extensive surgical approach, as proposed by Japanese surgeons, has been applied in our center over the last 5 years; it combines hilar resection with partial hepatectomy for most @entity2 . The aim of this study was to assess the outcome of a 15-year evolution in the surgical treatment of @entity4 . METHODS: A total of 99 consecutive @entity0 underwent resection for @entity3 in three 5-year time periods: periods 1 (1988-1993; n=45), 2 (1993-1998; n=25), and 3 (1998-2003; n=29). Outcome was evaluated by assessment of completeness of resection, postoperative morbidity and mortality, and survival. RESULTS: The proportion of margin negative resections increased significantly from 13% in period 1 to 59% in period 3 (P<.05). Two-year survival increased significantly from 33%+/-7% and 39%+/-10% in periods 1 and 2 to 60%+/-11% in period 3 (P<.05). Postoperative morbidity and mortality were considerable but did not increase with this changed surgical strategy (68% and 10%, respectively, in period 3). Lymph node @entity1 was, next to period of resection, also associated with survival in univariate analysis. CONCLUSIONS: Mainly in the last 5-year period (1998-2003), when the Japanese surgical approach was followed, more hilar resections were combined with partial liver resections that included segments 1 and 4, thus leading to more R0 resections. This, together with a decrease in lymph node @entity1 , resulted in improved survival without significantly affecting postoperative morbidity or mortality.

title: Improved outcome of resection of XXXX ( @entity4 ).

answer: @entity3


abstract: BACKGROUND: Treatment of @entity3 ( @entity4 ) has changed in many aspects. A more extensive surgical approach, as proposed by Japanese surgeons, has been applied in our center over the last 5 years; it combines hilar resection with partial hepatectomy for most @entity2 . The aim of this study was to assess the outcome of a 15-year evolution in the surgical treatment of @entity4 . METHODS: A total of 99 consecutive @entity0 underwent resection for @entity3 in three 5-year time periods: periods 1 (1988-1993; n=45), 2 (1993-1998; n=25), and 3 (1998-2003; n=29). Outcome was evaluated by assessment of completeness of resection, postoperative morbidity and mortality, and survival. RESULTS: The proportion of margin negative resections increased significantly from 13% in period 1 to 59% in period 3 (P<.05). Two-year survival increased significantly from 33%+/-7% and 39%+/-10% in periods 1 and 2 to 60%+/-11% in period 3 (P<.05). Postoperative morbidity and mortality were considerable but did not increase with this changed surgical strategy (68% and 10%, respectively, in period 3). Lymph node @entity1 was, next to period of resection, also associated with survival in univariate analysis. CONCLUSIONS: Mainly in the last 5-year period (1998-2003), when the Japanese surgical approach was followed, more hilar resections were combined with partial liver resections that included segments 1 and 4, thus leading to more R0 resections. This, together with a decrease in lymph node @entity1 , resulted in improved survival without significantly affecting postoperative morbidity or mortality.

title: Improved outcome of resection of @entity3 ( XXXX ).

answer: @entity4


abstract: The effects of continuous lumbar epidural anesthesia and two types of general anesthesia on @entity1 and hemodynamics during and after total hip replacement were compared in three groups of @entity0 . Fourteen @entity0 received local anesthetics via continuous lumbar epidural administration; 10 @entity0 received inhalational anesthetics and breathed spontaneously after endotracheal intubation; and 14 received artificial ventilation after intubation and intermittent intravenous (i.v.) injections of @entity4 and @entity3 . The results documented that both intraoperative and postoperative blood losses were significantly reduced in @entity0 subjected to total hip replacement under lumbar epidural anesthesia as compared with the @entity0 receiving the two general anesthetic techniques. Hemodynamic differences explained the differences in @entity1 . The epidural anesthesia induced @entity2 on the arterial and venous sides as compared with the two general anesthetic techniques. Inhalational anesthesia also induced @entity2 on the arterial and venous sides intraoperatively as compared with general anesthesia with artificial ventilation. Postoperatively, the hemodynamics of the general anesthesia groups were similar, and no differences in @entity1 occurred. Continuous' epidural anesthesia can be viewed as a tool to achieve @entity2 anesthesia--notably on the venous side--for the purpose of minimizing @entity1 . The reduction in @entity1 associated with lumbar epidural anesthesia is beneficial in decreasing the hazard and cost of blood transfusion.

title: Beneficial effects on intraoperative and postoperative XXXX in total hip replacement when performed under lumbar epidural anesthesia. An explanatory study.

answer: @entity1


abstract: BACKGROUND: @entity0 present to the National University Hospital of Singapore and select one of several health screening packages after counselling. The prevalence of @entity5 ( @entity5 ) in this population when different glomerular filtration rate (GFR) estimating equations are used has not been examined. METHODS: Demographic data and urinalyses of @entity0 from 2000 to 2005 were extracted from laboratory computer databases and analysed. @entity5 was classified into stages according to the US National Kidney Foundation guidelines by @entity2 (mL/min per 1.73 m(2)) using the four-variable Modification of Diet in @entity1 equation. GFR of ethnic Chinese was also estimated using Ma's equation 8 (cGFR). Stage 1 and normal ( @entity2 or cGFR > 90) was discriminated by urinary microscopy or dipstick for @entity4 , @entity3 , @entity6 or leukocyturia. RESULTS: There were 3979 screenings (55.9% males, 61.9% Chinese). Means: age = 47.0 +/- 12.3 years, @entity7 = 80.1 +/- 26.5 micromol/L, @entity2 = 89.6 +/- 19.7, cGFR = 110.8 +/- 23.8 and ( @entity2 + cGFR) = 102.5 +/- 24.9. By @entity2 in all @entity0 , the prevalence of @entity5 was 45.7%, 50.6%, 3.3%, 0.3% and 0.08% for stages normal @entity8 , respectively. For Chinese @entity0 only, @entity2 and cGFR resulted in a different distribution ( @entity2 %/cGFR%): 24.9/50.5, 15.2/29.3, 56.8/19.7, 3/0.8, 0.2/0.2, 0/0 for stages 'Normal', 1, 2, 3, 4 and 5, respectively (P < 0.001). CONCLUSION: The prevalence of moderate to severe @entity5 (stage 3 to 5) in @entity0 presenting for health screening in Singapore was 3.7%. Notably, the prevalence of mild to moderate @entity5 (stages 1, 2 and 3) in Chinese @entity0 was affected significantly by the choice of GFR estimating equation.

title: The choice of estimating equations for glomerular filtration rate significantly affects the prevalence of XXXX in a multi-ethnic population during health screening.

answer: @entity5


abstract: Extracellular @entity3 is known to mediate fast, excitatory neurotransmission through activation of ionotropic P2X receptors. In this study, the localization of the P2X(2) receptor (P2X(2)R) subunit was studied in @entity0 retina by using immunofluorescence immunohistochemistry and preembedding immunoelectron microscopy. The P2X(2)R was observed in large ganglion cells as well as in a subset of amacrine cells. Double labeling revealed that 96% of all P2X(2)R-immunoreactive amacrine cells showed @entity4 ( @entity4 ) immunoreactivity. Subsets of P2X(2)R-immunoreactive amacrine cells expressed @entity2 synthase and substance P; however, no colocalization was observed with @entity5 acetyltransferase, vasoactive intestinal peptide, or @entity1 hydroxylase. Nearest-neighbor analysis confirmed that P2X(2)Rs were expressed by a heterogeneous population of amacrine cells. The synaptic connectivity of P2X(2)R amacrine cells was also investigated. It was interesting that P2X(2)R-immunoreactive amacrine cell dendrites stratified in the sublaminae of the inner plexiform layer occupied by cone, but not rod bipolar cell axon terminals. Immunoelectron microscopy revealed that P2X(2)-immunoreactive amacrine cell processes were associated with cone bipolar cell axon terminals as well as other conventional synapses in the inner plexiform layer. Taken together, these data provide further evidence for the involvement of extracellular @entity3 in neuronal signaling in the retina, particularly within cone pathways.

title: P2X2 receptors on ganglion and amacrine cells in cone pathways of the XXXX retina.

answer: @entity0


abstract: @entity7 is one of the causative factors of @entity14 , and @entity13 ( @entity13 ) is a subtype of primary extranodal @entity2 . A 69-year-old @entity1 visited our hospital because of general fatigue. We diagnosed her with presumable non-functional primary @entity9 . Eight months after, the @entity1 revisited our hospital because of @entity10 . Though we conducted systemic investigations including chest and abdomen enhanced computer tomography, transbronchial lung biopsy, and bone marrow biopsy, the diagnosis was not confirmed. Inadvertently, a @entity0 was found, and the surgical specimen proved that the @entity1 had double @entity2 and @entity13 . Rituximab, @entity8 , @entity6 , @entity12 , and @entity5 regimen was initiated, and complete remission was achieved. Notably, the sellar mass returned to normal size with improved function. We reviewed 32 @entity1 with primary @entity7 . In affected sites, both sellar and @entity14 (6.7%), both hypothalamus and @entity14 (6.7%), only sellar (63.3%), only @entity14 (6.7%), only hypothalamus (13.3%), and only clivus (3.3%) were observed. In @entity14 , both anterior and @entity4 (20.7%), only anterior dysfunction (58.6%), only @entity4 (3.4%), and no dysfunction (17.2%) were observed. It seemed that @entity11 is related to both anterior and @entity4 , while sellar lesion is related to mainly anterior dysfunction. In @entity3 , 2nd @entity3 (45.2%) and 6th @entity3 (35.5%) were frequently observed. It seemed that sellar lesion is related to both 2nd and 6th @entity3 , while @entity11 is related to mainly 2nd @entity3 .

title: @entity7 : XXXX diagnosed as a double @entity2 and improved with chemotherapy, and literature review of primary @entity7 .

answer: @entity13


abstract: @entity7 is one of the causative factors of @entity14 , and @entity13 ( @entity13 ) is a subtype of primary extranodal @entity2 . A 69-year-old @entity1 visited our hospital because of general fatigue. We diagnosed her with presumable non-functional primary @entity9 . Eight months after, the @entity1 revisited our hospital because of @entity10 . Though we conducted systemic investigations including chest and abdomen enhanced computer tomography, transbronchial lung biopsy, and bone marrow biopsy, the diagnosis was not confirmed. Inadvertently, a @entity0 was found, and the surgical specimen proved that the @entity1 had double @entity2 and @entity13 . Rituximab, @entity8 , @entity6 , @entity12 , and @entity5 regimen was initiated, and complete remission was achieved. Notably, the sellar mass returned to normal size with improved function. We reviewed 32 @entity1 with primary @entity7 . In affected sites, both sellar and @entity14 (6.7%), both hypothalamus and @entity14 (6.7%), only sellar (63.3%), only @entity14 (6.7%), only hypothalamus (13.3%), and only clivus (3.3%) were observed. In @entity14 , both anterior and @entity4 (20.7%), only anterior dysfunction (58.6%), only @entity4 (3.4%), and no dysfunction (17.2%) were observed. It seemed that @entity11 is related to both anterior and @entity4 , while sellar lesion is related to mainly anterior dysfunction. In @entity3 , 2nd @entity3 (45.2%) and 6th @entity3 (35.5%) were frequently observed. It seemed that sellar lesion is related to both 2nd and 6th @entity3 , while @entity11 is related to mainly 2nd @entity3 .

title: XXXX : @entity13 diagnosed as a double @entity2 and improved with chemotherapy, and literature review of primary @entity7 .

answer: @entity7


abstract: @entity7 is one of the causative factors of @entity14 , and @entity13 ( @entity13 ) is a subtype of primary extranodal @entity2 . A 69-year-old @entity1 visited our hospital because of general fatigue. We diagnosed her with presumable non-functional primary @entity9 . Eight months after, the @entity1 revisited our hospital because of @entity10 . Though we conducted systemic investigations including chest and abdomen enhanced computer tomography, transbronchial lung biopsy, and bone marrow biopsy, the diagnosis was not confirmed. Inadvertently, a @entity0 was found, and the surgical specimen proved that the @entity1 had double @entity2 and @entity13 . Rituximab, @entity8 , @entity6 , @entity12 , and @entity5 regimen was initiated, and complete remission was achieved. Notably, the sellar mass returned to normal size with improved function. We reviewed 32 @entity1 with primary @entity7 . In affected sites, both sellar and @entity14 (6.7%), both hypothalamus and @entity14 (6.7%), only sellar (63.3%), only @entity14 (6.7%), only hypothalamus (13.3%), and only clivus (3.3%) were observed. In @entity14 , both anterior and @entity4 (20.7%), only anterior dysfunction (58.6%), only @entity4 (3.4%), and no dysfunction (17.2%) were observed. It seemed that @entity11 is related to both anterior and @entity4 , while sellar lesion is related to mainly anterior dysfunction. In @entity3 , 2nd @entity3 (45.2%) and 6th @entity3 (35.5%) were frequently observed. It seemed that sellar lesion is related to both 2nd and 6th @entity3 , while @entity11 is related to mainly 2nd @entity3 .

title: @entity7 : @entity13 diagnosed as a double @entity2 and improved with chemotherapy, and literature review of primary XXXX .

answer: @entity7


abstract: @entity7 is one of the causative factors of @entity14 , and @entity13 ( @entity13 ) is a subtype of primary extranodal @entity2 . A 69-year-old @entity1 visited our hospital because of general fatigue. We diagnosed her with presumable non-functional primary @entity9 . Eight months after, the @entity1 revisited our hospital because of @entity10 . Though we conducted systemic investigations including chest and abdomen enhanced computer tomography, transbronchial lung biopsy, and bone marrow biopsy, the diagnosis was not confirmed. Inadvertently, a @entity0 was found, and the surgical specimen proved that the @entity1 had double @entity2 and @entity13 . Rituximab, @entity8 , @entity6 , @entity12 , and @entity5 regimen was initiated, and complete remission was achieved. Notably, the sellar mass returned to normal size with improved function. We reviewed 32 @entity1 with primary @entity7 . In affected sites, both sellar and @entity14 (6.7%), both hypothalamus and @entity14 (6.7%), only sellar (63.3%), only @entity14 (6.7%), only hypothalamus (13.3%), and only clivus (3.3%) were observed. In @entity14 , both anterior and @entity4 (20.7%), only anterior dysfunction (58.6%), only @entity4 (3.4%), and no dysfunction (17.2%) were observed. It seemed that @entity11 is related to both anterior and @entity4 , while sellar lesion is related to mainly anterior dysfunction. In @entity3 , 2nd @entity3 (45.2%) and 6th @entity3 (35.5%) were frequently observed. It seemed that sellar lesion is related to both 2nd and 6th @entity3 , while @entity11 is related to mainly 2nd @entity3 .

title: @entity7 : @entity13 diagnosed as a double XXXX and improved with chemotherapy, and literature review of primary @entity7 .

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: To analyze treatment and survival in 34 @entity0 (28 resected) with primary or recurrent @entity2 ( @entity2 ). METHODS: Between July 1994 and January 2001, 34 @entity0 (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross @entity1 with histologically confirmed clear resection margins. RESULTS: Twenty-eight out of 34 @entity0 (82%) (15 were affected by primary @entity2 , and 13 by recurrent @entity2 ), underwent surgical exploration. Twenty-three @entity0 had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 @entity0 with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 @entity0 (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High @entity1 grade results a significant variable for a worse survival in all 28 @entity0 (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected @entity0 , only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). CONCLUSIONS: An aggressive surgical approach in both primary and recurrent @entity2 is associated with long-term survival.

title: Primary and recurrent XXXX : prognostic factors affecting survival.

answer: @entity2


abstract: OBJECTIVE: To investigate the neuroprotective effects and dose-response relation by combining JAK-STAT signal pathway inhibitor ( @entity7 ) with free radical scavenger @entity6 ( @entity6 ) in @entity1 subjected to focal @entity4 /reperfusion (I/R) injury. METHODS: In all @entity1 , the @entity3 ( @entity3 ) was produced by occlusion of right internal carotid artery with a nylon monofilament. One hundred male Sprague-Dawley (SD) @entity1 were divided into ten groups according to random digits table, 10 @entity1 were in each group. The first experiment involved I/R model control, @entity5 ( @entity5 ) control, normal saline (NS) control, @entity7 , @entity6 and combination of @entity7 and @entity6 (A+D) groups. The second experiment involved model group and three experimental groups in which various doses of @entity6 and @entity7 were administered. The @entity0 ( @entity0 ) were assessed at 24, 48 and 72 hours after reperfusion respectively in both experiments, and all the animals were then decapitated to determine the brain @entity2 volume after 72 hours. RESULTS: The values of @entity0 in A+D group, @entity7 group and @entity6 group were higher than those in model group at 24, 48 and 72 hours after I/R, and their brain @entity2 volumes were obviously smaller than model group as well (all P<0.05). The brain @entity2 volume in A+D group was obviously smaller compared with @entity7 and @entity6 alone (all P<0.05). The values of @entity0 were higher and the brain @entity2 volumes were smaller in both high dose and medium dose combination groups than those in low dose combination and model groups respectively (all P<0.05). In addition, brain @entity2 volumes in high dose group were smaller than medium dose group (P<0.05), but there was no statistically significant difference between low dose and model groups. CONCLUSION: The combined application of @entity7 and @entity6 produces a dose-dependent synergistic neuroprotective effect.

title: [Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal XXXX /reperfusion injury in @entity1 ].

answer: @entity4


abstract: OBJECTIVE: To investigate the neuroprotective effects and dose-response relation by combining JAK-STAT signal pathway inhibitor ( @entity7 ) with free radical scavenger @entity6 ( @entity6 ) in @entity1 subjected to focal @entity4 /reperfusion (I/R) injury. METHODS: In all @entity1 , the @entity3 ( @entity3 ) was produced by occlusion of right internal carotid artery with a nylon monofilament. One hundred male Sprague-Dawley (SD) @entity1 were divided into ten groups according to random digits table, 10 @entity1 were in each group. The first experiment involved I/R model control, @entity5 ( @entity5 ) control, normal saline (NS) control, @entity7 , @entity6 and combination of @entity7 and @entity6 (A+D) groups. The second experiment involved model group and three experimental groups in which various doses of @entity6 and @entity7 were administered. The @entity0 ( @entity0 ) were assessed at 24, 48 and 72 hours after reperfusion respectively in both experiments, and all the animals were then decapitated to determine the brain @entity2 volume after 72 hours. RESULTS: The values of @entity0 in A+D group, @entity7 group and @entity6 group were higher than those in model group at 24, 48 and 72 hours after I/R, and their brain @entity2 volumes were obviously smaller than model group as well (all P<0.05). The brain @entity2 volume in A+D group was obviously smaller compared with @entity7 and @entity6 alone (all P<0.05). The values of @entity0 were higher and the brain @entity2 volumes were smaller in both high dose and medium dose combination groups than those in low dose combination and model groups respectively (all P<0.05). In addition, brain @entity2 volumes in high dose group were smaller than medium dose group (P<0.05), but there was no statistically significant difference between low dose and model groups. CONCLUSION: The combined application of @entity7 and @entity6 produces a dose-dependent synergistic neuroprotective effect.

title: [Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal @entity4 /reperfusion injury in XXXX ].

answer: @entity1


abstract: INTRODUCTION AND OBJECTIVES: To determine the incidence of and mortality due to @entity4 and @entity3 in the elderly population of Madrid, Spain. METHODS: The study involved a population-based cohort of 1297 individuals aged over 64 years without @entity2 who were recruited in 1995. All cases of fatal and non-fatal @entity4 recorded up until December 2004 were investigated and classified using WHO-MONICA (World Health Organization-Multinational MONItoring of trends and determinants in @entity2 ) criteria. RESULTS: @entity0 had a significantly higher cumulative incidence of @entity1 events (P< .001) and @entity5 (P< .001), and a non-significantly higher risk of @entity4 (6.30%; 95% confidence interval [CI], 4.33%-8.76%) than @entity0 (4.90%; 95% CI, 3.54%-6.70%; P=.181). While the risk of @entity4 increased with age (P< .05), gender differences tended to narrow. The incidence was higher in @entity0 (889/100 000 @entity0 -years) than @entity0 (610/100,000 @entity0 -years; P< .001) and increased with age (P< .01). This increase was progressive in @entity0 but not in @entity0 . The mortality rate was also higher in @entity0 (472/100,000 @entity0 -years; 95% CI, 248-697) than @entity0 (328/100,000 @entity0 -years; 95% CI, 188-469; P< .001), and was six times higher in the 385-year-old age group than in those aged 65-74 years (P< .001). CONCLUSIONS: The incidence of fatal and non-fatal @entity4 was very high in the elderly population of Madrid. Both incidence and mortality rates increased dramatically with age after 64 years. Rates were higher in @entity0 than @entity0 at all ages, though gender differences decreased with age.

title: [Ten-year incidence of fatal and non-fatal XXXX in the elderly population of Madrid].

answer: @entity4


abstract: INTRODUCTION AND OBJECTIVES: The Spanish province of C  diz has some of the poorest socioeconomic conditions and the highest @entity3 and mortality rates in the country. The aim of this study was to investigate the prevalence of cardiovascular risk factors in the adult population of the city of Sanl  car de Barrameda in C  diz. METHODS: This cross-sectional population-based study involved 858 randomly selected individuals aged 50-75 years. Age- and sex-adjusted prevalences of the main cardiovascular risk factors were obtained. RESULTS: The mean age of the study population was 61.5 years and 53.6% were @entity0 . Overall, 46% of @entity0 and 61.7% of @entity0 were illiterate; 23.7% and 7.9%, respectively, were current smokers; 30.9% and 44.8% had a sedentary lifestyle; 54% and 55.9% were @entity2 ; 29.4% and 26.1% had @entity1 ; 45% and 52.4% had @entity4 ; 40.9% and 45.1% had @entity7 ; and 58.8% and 57% had @entity5 as defined by NCEP/ @entity6 -III criteria. The prevalence of all cardiovascular risk factors, except smoking, increased with age. Significant inverse associations were observed between educational level and @entity2 in @entity0 and between educational level and @entity1 and @entity5 in @entity0 . CONCLUSIONS: The prevalence of cardiovascular risk factors in individuals aged 50-75 years in Sanl  car de Barrameda was extremely high. The prevalences of @entity2 , @entity1 and @entity5 were among the highest ever reported in Spain. A very low educational level may underlie these adverse findings.

title: [Prevalence of @entity2 , @entity1 , XXXX , @entity7 and @entity5 in over 50-year-olds in Sanl  car de Barrameda, Spain].

answer: @entity4


abstract: INTRODUCTION AND OBJECTIVES: The Spanish province of C  diz has some of the poorest socioeconomic conditions and the highest @entity3 and mortality rates in the country. The aim of this study was to investigate the prevalence of cardiovascular risk factors in the adult population of the city of Sanl  car de Barrameda in C  diz. METHODS: This cross-sectional population-based study involved 858 randomly selected individuals aged 50-75 years. Age- and sex-adjusted prevalences of the main cardiovascular risk factors were obtained. RESULTS: The mean age of the study population was 61.5 years and 53.6% were @entity0 . Overall, 46% of @entity0 and 61.7% of @entity0 were illiterate; 23.7% and 7.9%, respectively, were current smokers; 30.9% and 44.8% had a sedentary lifestyle; 54% and 55.9% were @entity2 ; 29.4% and 26.1% had @entity1 ; 45% and 52.4% had @entity4 ; 40.9% and 45.1% had @entity7 ; and 58.8% and 57% had @entity5 as defined by NCEP/ @entity6 -III criteria. The prevalence of all cardiovascular risk factors, except smoking, increased with age. Significant inverse associations were observed between educational level and @entity2 in @entity0 and between educational level and @entity1 and @entity5 in @entity0 . CONCLUSIONS: The prevalence of cardiovascular risk factors in individuals aged 50-75 years in Sanl  car de Barrameda was extremely high. The prevalences of @entity2 , @entity1 and @entity5 were among the highest ever reported in Spain. A very low educational level may underlie these adverse findings.

title: [Prevalence of @entity2 , @entity1 , @entity4 , @entity7 and XXXX in over 50-year-olds in Sanl  car de Barrameda, Spain].

answer: @entity5


abstract: INTRODUCTION AND OBJECTIVES: The Spanish province of C  diz has some of the poorest socioeconomic conditions and the highest @entity3 and mortality rates in the country. The aim of this study was to investigate the prevalence of cardiovascular risk factors in the adult population of the city of Sanl  car de Barrameda in C  diz. METHODS: This cross-sectional population-based study involved 858 randomly selected individuals aged 50-75 years. Age- and sex-adjusted prevalences of the main cardiovascular risk factors were obtained. RESULTS: The mean age of the study population was 61.5 years and 53.6% were @entity0 . Overall, 46% of @entity0 and 61.7% of @entity0 were illiterate; 23.7% and 7.9%, respectively, were current smokers; 30.9% and 44.8% had a sedentary lifestyle; 54% and 55.9% were @entity2 ; 29.4% and 26.1% had @entity1 ; 45% and 52.4% had @entity4 ; 40.9% and 45.1% had @entity7 ; and 58.8% and 57% had @entity5 as defined by NCEP/ @entity6 -III criteria. The prevalence of all cardiovascular risk factors, except smoking, increased with age. Significant inverse associations were observed between educational level and @entity2 in @entity0 and between educational level and @entity1 and @entity5 in @entity0 . CONCLUSIONS: The prevalence of cardiovascular risk factors in individuals aged 50-75 years in Sanl  car de Barrameda was extremely high. The prevalences of @entity2 , @entity1 and @entity5 were among the highest ever reported in Spain. A very low educational level may underlie these adverse findings.

title: [Prevalence of XXXX , @entity1 , @entity4 , @entity7 and @entity5 in over 50-year-olds in Sanl  car de Barrameda, Spain].

answer: @entity2


abstract: INTRODUCTION AND OBJECTIVES: The Spanish province of C  diz has some of the poorest socioeconomic conditions and the highest @entity3 and mortality rates in the country. The aim of this study was to investigate the prevalence of cardiovascular risk factors in the adult population of the city of Sanl  car de Barrameda in C  diz. METHODS: This cross-sectional population-based study involved 858 randomly selected individuals aged 50-75 years. Age- and sex-adjusted prevalences of the main cardiovascular risk factors were obtained. RESULTS: The mean age of the study population was 61.5 years and 53.6% were @entity0 . Overall, 46% of @entity0 and 61.7% of @entity0 were illiterate; 23.7% and 7.9%, respectively, were current smokers; 30.9% and 44.8% had a sedentary lifestyle; 54% and 55.9% were @entity2 ; 29.4% and 26.1% had @entity1 ; 45% and 52.4% had @entity4 ; 40.9% and 45.1% had @entity7 ; and 58.8% and 57% had @entity5 as defined by NCEP/ @entity6 -III criteria. The prevalence of all cardiovascular risk factors, except smoking, increased with age. Significant inverse associations were observed between educational level and @entity2 in @entity0 and between educational level and @entity1 and @entity5 in @entity0 . CONCLUSIONS: The prevalence of cardiovascular risk factors in individuals aged 50-75 years in Sanl  car de Barrameda was extremely high. The prevalences of @entity2 , @entity1 and @entity5 were among the highest ever reported in Spain. A very low educational level may underlie these adverse findings.

title: [Prevalence of @entity2 , XXXX , @entity4 , @entity7 and @entity5 in over 50-year-olds in Sanl  car de Barrameda, Spain].

answer: @entity1


abstract: INTRODUCTION AND OBJECTIVES: The Spanish province of C  diz has some of the poorest socioeconomic conditions and the highest @entity3 and mortality rates in the country. The aim of this study was to investigate the prevalence of cardiovascular risk factors in the adult population of the city of Sanl  car de Barrameda in C  diz. METHODS: This cross-sectional population-based study involved 858 randomly selected individuals aged 50-75 years. Age- and sex-adjusted prevalences of the main cardiovascular risk factors were obtained. RESULTS: The mean age of the study population was 61.5 years and 53.6% were @entity0 . Overall, 46% of @entity0 and 61.7% of @entity0 were illiterate; 23.7% and 7.9%, respectively, were current smokers; 30.9% and 44.8% had a sedentary lifestyle; 54% and 55.9% were @entity2 ; 29.4% and 26.1% had @entity1 ; 45% and 52.4% had @entity4 ; 40.9% and 45.1% had @entity7 ; and 58.8% and 57% had @entity5 as defined by NCEP/ @entity6 -III criteria. The prevalence of all cardiovascular risk factors, except smoking, increased with age. Significant inverse associations were observed between educational level and @entity2 in @entity0 and between educational level and @entity1 and @entity5 in @entity0 . CONCLUSIONS: The prevalence of cardiovascular risk factors in individuals aged 50-75 years in Sanl  car de Barrameda was extremely high. The prevalences of @entity2 , @entity1 and @entity5 were among the highest ever reported in Spain. A very low educational level may underlie these adverse findings.

title: [Prevalence of @entity2 , @entity1 , @entity4 , XXXX and @entity5 in over 50-year-olds in Sanl  car de Barrameda, Spain].

answer: @entity7


abstract: Between 1970 and 1983, 46 @entity0 were hospitalized in the Vanderbilt University Medical Center and the Metropolitan Nashville General Hospital for treatment of @entity3 . All @entity0 had been symptomatic for at least two years. Efforts were made initially to manage most of these @entity0 (40) with periodic esophageal dilatation. This was successful in only six cases (15%). In four instances (10%), @entity0 had esophageal perforation. Thirty @entity0 have had esophagomyotomy (Heller procedure), and 14 of these had an associated antireflux procedure. Three had proximal gastric vagotomy for associated @entity4 . Twenty-seven (90%) have had a good result, three died postoperatively, and two elderly @entity0 had @entity2 . The other @entity0 had @entity1 after repair of a perforated esophagus. While periodic esophageal dilatation is necessary in @entity0 who may not tolerate an operative procedure, most @entity0 with @entity3 are best treated with Heller esophagomyotomy.

title: Surgical management of XXXX .

answer: @entity3


abstract: In this review we have summarized our experiences of serological analysis of @entity7 expression in @entity0 B cell malignant disease. Cells from a large number of cases of @entity3 ( @entity6 ) and @entity4 ( @entity4 ) have been examined for expression of class II antigens. Using a number of monoclonal antibodies which in some cases are specific for class II subregion products (DP, DQ and DR), MHC class II antigens were detected by indirect immunofluorescence and fluorescent activated cell sorter analysis in @entity6 and by immunohistochemical staining in @entity4 . At the cell surface in many cases of B cell malignant disease, products of the different class II subregion genes are non-coordinately expressed. The most commonly occurring pattern of non-coordinate expression of class II molecules is of expression of DP and DR antigens in the absence of detectable DQ expression. These findings are in contrast to normal B lymphocytes where DP, DQ and DR antigens are expressed together at the cell surface. There is considerable heterogeneity among cases comprising individual histopathological categories of B cell malignancy, and in many instances heterogeneous class II phenotypes are also found on cells from the same @entity1 . In @entity6 , class II antigen expression is inducible in vitro by treating the cells with the @entity5 TPA. @entity6 cells treated with @entity2 have much increased levels of class II antigen expression at the cell surface and much increased steady state levels of class II specific mRNA transcripts detectable with complementary DNA probes. Aberrant class II antigen expression may be involved in the pathogenesis of B cell malignant disease.

title: Expression of MHC class II antigens in @entity0 B-cell leukaemia and XXXX .

answer: @entity4


abstract: In this review we have summarized our experiences of serological analysis of @entity7 expression in @entity0 B cell malignant disease. Cells from a large number of cases of @entity3 ( @entity6 ) and @entity4 ( @entity4 ) have been examined for expression of class II antigens. Using a number of monoclonal antibodies which in some cases are specific for class II subregion products (DP, DQ and DR), MHC class II antigens were detected by indirect immunofluorescence and fluorescent activated cell sorter analysis in @entity6 and by immunohistochemical staining in @entity4 . At the cell surface in many cases of B cell malignant disease, products of the different class II subregion genes are non-coordinately expressed. The most commonly occurring pattern of non-coordinate expression of class II molecules is of expression of DP and DR antigens in the absence of detectable DQ expression. These findings are in contrast to normal B lymphocytes where DP, DQ and DR antigens are expressed together at the cell surface. There is considerable heterogeneity among cases comprising individual histopathological categories of B cell malignancy, and in many instances heterogeneous class II phenotypes are also found on cells from the same @entity1 . In @entity6 , class II antigen expression is inducible in vitro by treating the cells with the @entity5 TPA. @entity6 cells treated with @entity2 have much increased levels of class II antigen expression at the cell surface and much increased steady state levels of class II specific mRNA transcripts detectable with complementary DNA probes. Aberrant class II antigen expression may be involved in the pathogenesis of B cell malignant disease.

title: Expression of MHC class II antigens in XXXX B-cell leukaemia and @entity4 .

answer: @entity0


abstract: Serial HIDA scanning was performed on a @entity0 following liver transplantation. During the @entity0 's course he developed @entity3 that manifested as a photopenic region in the liver, on the HIDA scan which filled in on the delayed views. The @entity0 subsequently developed a region in the superior portion of the right lobe of the liver that did not fill in with activity on delayed views. The @entity0 was experiencing low-grade fevers and was clinically believed to have either an @entity5 or an episode of rejection. A gallium scan was performed revealing a @entity2 in the same region as the HIDA. Because of the clinical suspicion of @entity5 , a percutaneous transhepatic drainage study was performed, revealing a large @entity5 cavity in the suspect area within the liver. Following the drainage the @entity0 did well. This case illustrates the usefulness of serial HIDA scanning in @entity0 who have received liver transplants. It also is important to note that the @entity6 scan was negative in this @entity1 . In the authors' opinions, the finding of an intrahepatic fluid collection in a septic @entity0 that does not fill with activity on the HIDA study, should be considered the source of the @entity4 , until proven otherwise, and should be drained regardless of the findings of other studies.

title: XXXX in liver transplantation. Accurate diagnosis and treatment.

answer: @entity1


abstract: Previous studies with @entity1 kidneys in our laboratories have used a plasma-like solution as the vehicle for the introduction and removal of @entity5 . Other workers have usually employed high- @entity6 solutions. In this study we have assayed the function of @entity1 renal cortical slices after incubation in a range of solutions, each of which contained 1 M @entity5 , for 4 hr, followed by stepwise removal of the cryoprotectant. The functions measured were endogenous @entity0 consumption, @entity12 uptake, and the ability of the slices to accumulate @entity6 . Exposure to @entity5 produced a considerable reduction of slice function, but, in the presence of @entity5 , elevation of the @entity6 concentration was beneficial, whereas high concentrations of @entity7 were detrimental. The optimum @entity6 concentration was 70-100 mM. Replacement of @entity10 by a range of anions of higher molecular weight was either without benefit ( @entity14 ) or detrimental ( @entity4 , @entity8 , and @entity13 ). Elevation of total osmolality from 300 to 400 mosmolal with @entity2 , @entity9 , @entity14 , or Pipes reduced slice function, but when the same osmolality was achieved by raising the concentration of all the components of the solution in the same ratio, there was no significant loss of function. There was a weak optimum pH at ca. 7.0. These experiments led to the formulation of a @entity11 -buffered perfusate containing 80 mM @entity6 and 17.5 g Haemaccel per liter, having a pH of 7.0 with 5% @entity3 at 10 degrees C, and an osmolality of 400 mosmol/kg. This solution was used to preserve @entity1 kidneys for 20 hr at 10 degrees C, by continuous perfusion, and was compared with our previous Haemaccel perfusate, HP5, which contained 4 mM K+, 111 mM @entity9 , and had a pH of 7.4. The two solutions were equally effective.

title: Optimization of a vehicle solution for the introduction and removal of @entity5 with XXXX kidneys.

answer: @entity1


abstract: Previous studies with @entity1 kidneys in our laboratories have used a plasma-like solution as the vehicle for the introduction and removal of @entity5 . Other workers have usually employed high- @entity6 solutions. In this study we have assayed the function of @entity1 renal cortical slices after incubation in a range of solutions, each of which contained 1 M @entity5 , for 4 hr, followed by stepwise removal of the cryoprotectant. The functions measured were endogenous @entity0 consumption, @entity12 uptake, and the ability of the slices to accumulate @entity6 . Exposure to @entity5 produced a considerable reduction of slice function, but, in the presence of @entity5 , elevation of the @entity6 concentration was beneficial, whereas high concentrations of @entity7 were detrimental. The optimum @entity6 concentration was 70-100 mM. Replacement of @entity10 by a range of anions of higher molecular weight was either without benefit ( @entity14 ) or detrimental ( @entity4 , @entity8 , and @entity13 ). Elevation of total osmolality from 300 to 400 mosmolal with @entity2 , @entity9 , @entity14 , or Pipes reduced slice function, but when the same osmolality was achieved by raising the concentration of all the components of the solution in the same ratio, there was no significant loss of function. There was a weak optimum pH at ca. 7.0. These experiments led to the formulation of a @entity11 -buffered perfusate containing 80 mM @entity6 and 17.5 g Haemaccel per liter, having a pH of 7.0 with 5% @entity3 at 10 degrees C, and an osmolality of 400 mosmol/kg. This solution was used to preserve @entity1 kidneys for 20 hr at 10 degrees C, by continuous perfusion, and was compared with our previous Haemaccel perfusate, HP5, which contained 4 mM K+, 111 mM @entity9 , and had a pH of 7.4. The two solutions were equally effective.

title: Optimization of a vehicle solution for the introduction and removal of XXXX with @entity1 kidneys.

answer: @entity5


abstract: Vaginal application of tablets containing @entity4 at term in pregnant @entity0 with a favorable cervical score is a very efficacious method of induction of labour. Due to the motility of the @entity0 they consider this method of induction as almost natural. We, therefore, aimed at discussing the optimal procedure in low-risk pregnancies at due date, by means of a prospective randomised trial. In 345 @entity0 with a favourable cervical score, labour was either induced by means of intravaginal application of tablets containing @entity3 according to a precise plan, or spontaneous onset of labour was awaited while CTG-controls were performed on an outpatient basis every second day until the 42nd week of pregnancy was completed. 80 per cent of the nulliparas and 96.3 per cent of the multiparas of the induction group delivered within 24 hours of the first tablet application. All pertinent delivery intervals were significantly shorter in this group compared to those @entity0 where spontaneous onset of labour was awaited. The incidence of @entity2 was low in both groups and not significantly different. Only 4.2 per cent of the @entity0 in the group where spontaneous labour was awaited, reached the completed 42nd week of pregnancy. Only one @entity0 had to be induced because of a suspicious CTG. The rate of operative deliveries was lower in the induction group (1.1% versus 3.8% Caesarean sections). With the exception of one @entity1 due to a cord complication three days after the due date the foetal outcome was excellent in both groups. The acceptance of the procedure was tested by means of a questionnaire during the post partum period.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Labor induction with 3 mg of XXXX vaginal tablets. A renaissance of programmed labor? Results of a prospective randomized study].

answer: @entity3


abstract: Nowadays, there are new technologies in high-performance liquid chromatography columns available enabling faster and more efficient separations. In this work, we compared three different types of columns for the analysis of main soy @entity3 . The evaluated columns were a conventional reverse phase particle column, a fused-core particle column, and a monolithic column. The comparison was in terms of chromatographic parameters such as resolution, asymmetry, number of theoretical plates, variability of retention time, and peak width. The lower column pressure was provided by the monolithic column, although lower chromatographic performance was achieved. Conventional and fused-core particle columns presented similar pressure. Results also indicate that direct transfer between particle and monolithic columns is not possible requiring adjustment of conditions and a different method optimization strategy. The best chromatographic performance and separation speed were observed for the fused-core particle column. Also, the effect of sample solvent on the separation and peak shape was evaluated and indicated that monolithic column is the most affected especially when using higher concentrations of @entity2 or @entity1 . Sample solvent that showed the lowest effect on the chromatographic performance of the columns was @entity0 . Overall evaluation of @entity0 and @entity2 as mobile phase for the separation of @entity3 indicated higher chromatographic performance of @entity2 , although @entity0 may be an attractive alternative. Using @entity2 as mobile phase resulted in faster, higher resolution, narrower, and more symmetric peaks than @entity0 with all columns. It also generated the lower column pressure and flatter pressure profile due to mobile phase changes, and therefore, it presents a higher potential to be explored for the development of faster separation methods.

title: Comparison of different types of stationary phases for the analysis of soy XXXX by HPLC.

answer: @entity3


abstract: The development of better diagnostic tools and therapeutic modalities has increased the incidence of central nervous system (CNS) @entity1 in @entity2 @entity0 . @entity3 can result from CNS @entity1 and frustrate @entity2 treatment. The authors sought to investigate the outcomes and the roles of ventriculoperitoneal shunts (VPS) in @entity0 with CNS @entity1 . The medical records of 50 consecutive @entity0 who underwent VPS for @entity3 related to CNS @entity1 were analyzed retrospectively. Data included features of primary @entity2 , CNS involvement, clinical course and surgical outcome. Median @entity0 age was 55.0  years (range 25-77), and 30 female and 20 male @entity0 were included in the study. At the time of VPS, 10 @entity0 had parenchymal metastases only and 40 @entity0 had @entity5 ( @entity5 ). Symptom improvement was observed postoperatively in 40 @entity0 (80%), mean Karnofsky performance status (KPS) scale change was from 37.8 to 46.0, and median survival from VPS was 3.0  months (2  days to 54  months). A ventricular opening pressure of >30  cm @entity4 (HR 6.44, 95% CI 1.26-32.9, P  =  0.02) and further @entity2 treatment after VPS (HR 0.17, 95% CI 0.07-0.42, P  <  0.0001) were found to be independent risk factors of poorer and better survival, respectively. @entity3 in CNS @entity1 requiring VPS is commonly associated with @entity5 . VPS is an effective palliative measure and an adequate @entity2 treatment after VPS may provide the best means of improving survival.

title: Ventriculoperitoneal shunt for XXXX caused by central nervous system metastasis.

answer: @entity3


abstract: @entity10 ( @entity10 ) is the most common @entity2 . Genes related to the Ras/Raf signalling pathway have been implicated in the pathogenesis of @entity9 . The objective of this study was to investigate the presence of @entity7 mutations in sporadic BCCs as well as its correlation with the phenotype of @entity1 ( @entity1 ), the clinicopathological parameters of the @entity0 and @entity8 protein expression.  83 @entity10 specimens were screened for @entity7 mutations, applying polymerase chain reaction, single-stranded conformation polymorphism (PCR-SSCP) and DNA sequencing. @entity1 status was examined using mononucleotide microsatellite markers and @entity8 protein expression was demonstrated by immunohistochemical staining. A @entity12 @entity4 leading to a silent mutation @entity13 ; and a T to A transversion causing an @entity5 change ( @entity14 ) have been found. @entity1 was detected in 5% of the cases and @entity8 accumulation was present in 37/83 samples studied. Although rare @entity7 alterations have been observed in @entity10 , none of them harboured the hot-spot mutation @entity11 commonly present in @entity3 and @entity6 . Consequently, no correlation could be determined between @entity7 alterations, @entity1 status, the clinicopathological features and @entity8 protein expression. Our results are in favour of a secondary importance for Ras signalling cascade genes in @entity10 pathogenesis.

title: @entity7 mutations, XXXX and @entity8 protein expression in sporadic basal cell carcinomas.

answer: @entity1


abstract: @entity10 ( @entity10 ) is the most common @entity2 . Genes related to the Ras/Raf signalling pathway have been implicated in the pathogenesis of @entity9 . The objective of this study was to investigate the presence of @entity7 mutations in sporadic BCCs as well as its correlation with the phenotype of @entity1 ( @entity1 ), the clinicopathological parameters of the @entity0 and @entity8 protein expression.  83 @entity10 specimens were screened for @entity7 mutations, applying polymerase chain reaction, single-stranded conformation polymorphism (PCR-SSCP) and DNA sequencing. @entity1 status was examined using mononucleotide microsatellite markers and @entity8 protein expression was demonstrated by immunohistochemical staining. A @entity12 @entity4 leading to a silent mutation @entity13 ; and a T to A transversion causing an @entity5 change ( @entity14 ) have been found. @entity1 was detected in 5% of the cases and @entity8 accumulation was present in 37/83 samples studied. Although rare @entity7 alterations have been observed in @entity10 , none of them harboured the hot-spot mutation @entity11 commonly present in @entity3 and @entity6 . Consequently, no correlation could be determined between @entity7 alterations, @entity1 status, the clinicopathological features and @entity8 protein expression. Our results are in favour of a secondary importance for Ras signalling cascade genes in @entity10 pathogenesis.

title: @entity7 mutations, @entity1 and XXXX protein expression in sporadic basal cell carcinomas.

answer: @entity8


abstract: @entity10 ( @entity10 ) is the most common @entity2 . Genes related to the Ras/Raf signalling pathway have been implicated in the pathogenesis of @entity9 . The objective of this study was to investigate the presence of @entity7 mutations in sporadic BCCs as well as its correlation with the phenotype of @entity1 ( @entity1 ), the clinicopathological parameters of the @entity0 and @entity8 protein expression.  83 @entity10 specimens were screened for @entity7 mutations, applying polymerase chain reaction, single-stranded conformation polymorphism (PCR-SSCP) and DNA sequencing. @entity1 status was examined using mononucleotide microsatellite markers and @entity8 protein expression was demonstrated by immunohistochemical staining. A @entity12 @entity4 leading to a silent mutation @entity13 ; and a T to A transversion causing an @entity5 change ( @entity14 ) have been found. @entity1 was detected in 5% of the cases and @entity8 accumulation was present in 37/83 samples studied. Although rare @entity7 alterations have been observed in @entity10 , none of them harboured the hot-spot mutation @entity11 commonly present in @entity3 and @entity6 . Consequently, no correlation could be determined between @entity7 alterations, @entity1 status, the clinicopathological features and @entity8 protein expression. Our results are in favour of a secondary importance for Ras signalling cascade genes in @entity10 pathogenesis.

title: XXXX mutations, @entity1 and @entity8 protein expression in sporadic basal cell carcinomas.

answer: @entity7


abstract: The Hedgehog (Hh) signaling network is critical for patterning and organogenesis in mammals, and has been implicated in a variety of @entity1 . @entity3 (Smo), the gene encoding the principal signal transducer, is overexpressed frequently in @entity0 , and constitutive activation in @entity5 -SmoM2 @entity2 caused alterations in mammary gland morphology, increased proliferation, and changes in stem/progenitor cell number. Both in @entity2 and in clinical specimens, proliferative cells did not usually express detectable Smo, suggesting the hypothesis that Smo functioned in a non-cell autonomous manner to stimulate proliferation. Here, we employed a genetically tagged @entity2 model carrying a Cre-recombinase-dependent conditional allele of constitutively active Smo (SmoM2) to test this hypothesis. @entity5 -Cre- or adenoviral-Cre-mediated SmoM2 expression in the luminal epithelium, but not in the myoepithelium, was required for the hyper-proliferative phenotypes. High levels of proliferation were observed in cells adjacent or in close-proximity to Smo expressing cells demonstrating that SmoM2 expressing cells were stimulating proliferation via a paracrine or juxtacrine mechanism. In contrast, Smo expression altered luminal cell differentiation in a cell-autonomous manner. SmoM2 expressing cells, purified by fluorescence activated cell sorting (FACS) via the genetic fluorescent tag, expressed high levels of @entity10 , @entity7 , @entity8 , @entity9 and @entity6 , and lower levels of @entity4 and @entity11 , in comparison to wildtype cells. These studies provide insight into the mechanism of Smo activation in the mammary gland and its possible roles in breast tumorigenesis. In addition, these results also have potential implications for the interpretation of proliferative phenotypes commonly observed in other organs as a consequence of hedgehog signaling activation.

title: Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated XXXX .

answer: @entity3


abstract: Two experiments of Latin square design were made, each with four Friesian bull @entity0 fitted with re-entrant duodenal and ileal cannulas at 4-10 d of age. The @entity0 were used to study the effect of giving milk-substitutes containing 0, 300, 500 and 700 g bacterial protein (Pruteen)/kg total protein on apparent digestibility of @entity6 fractions and @entity5 and true digestibility of 3H-labelled milk protein and 35S-labelled bacterial protein in the small intestine. A third experiment of Latin square design with four intact Friesian @entity0 was used to measure apparent digestibility of nutrients throughout the alimentary tract and retention of N, @entity3 and @entity7 . At the duodenum, volume of outflow, its pH, and outflow of @entity1 ( @entity9 ), @entity10 (NPN) decreased with time after feeding. At the ileum, volume of outflow and @entity9 outflow were unaffected by time after feeding but @entity10 outflow decreased; NPN outflow at the ileum increased to a maximum 6 h after feeding and then declined. Increased inclusion of Pruteen did not affect the volume of outflow at the duodenum or ileum, but duodenal @entity10 outflow increased. At the ileum, pH values were lower and @entity9 , @entity10 and NPN outflows were higher with increasing concentration of Pruteen in the diet. Apparent digestibility in the small intestine tended to decrease with greater amounts of Pruteen, but was only significant for NPN. Apparent digestibility from mouth to ileum significantly decreased for @entity9 and @entity10 as Pruteen inclusion increased. @entity4 concentration in duodenal outflow, with the exception of that of @entity2 , reflected intake. The total amount of each @entity4 in ileal outflow increased and the apparent digestibility of most @entity5 decreased with greater amounts of Pruteen in the diet. Apparent digestibility of nucleic acid-N from Pruteen was very high. True digestibility in the small intestine and between mouth and ileum of 3H-labelled milk protein was high and did not differ between dietary treatments. True digestibility of 35S-labelled Pruteen was low for the @entity11 diet and tended to increase linearly as more dietary Pruteen was included. Dry matter concentration in faeces and a high apparent digestibility throughout the whole alimentary tract of @entity8 did not differ between treatments.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Digestion, absorption and utilization of single-cell protein by the preruminant @entity0 . The true digestibility of milk and bacterial protein and the apparent digestibility and utilization of their constituent XXXX .

answer: @entity5


abstract: Two experiments of Latin square design were made, each with four Friesian bull @entity0 fitted with re-entrant duodenal and ileal cannulas at 4-10 d of age. The @entity0 were used to study the effect of giving milk-substitutes containing 0, 300, 500 and 700 g bacterial protein (Pruteen)/kg total protein on apparent digestibility of @entity6 fractions and @entity5 and true digestibility of 3H-labelled milk protein and 35S-labelled bacterial protein in the small intestine. A third experiment of Latin square design with four intact Friesian @entity0 was used to measure apparent digestibility of nutrients throughout the alimentary tract and retention of N, @entity3 and @entity7 . At the duodenum, volume of outflow, its pH, and outflow of @entity1 ( @entity9 ), @entity10 (NPN) decreased with time after feeding. At the ileum, volume of outflow and @entity9 outflow were unaffected by time after feeding but @entity10 outflow decreased; NPN outflow at the ileum increased to a maximum 6 h after feeding and then declined. Increased inclusion of Pruteen did not affect the volume of outflow at the duodenum or ileum, but duodenal @entity10 outflow increased. At the ileum, pH values were lower and @entity9 , @entity10 and NPN outflows were higher with increasing concentration of Pruteen in the diet. Apparent digestibility in the small intestine tended to decrease with greater amounts of Pruteen, but was only significant for NPN. Apparent digestibility from mouth to ileum significantly decreased for @entity9 and @entity10 as Pruteen inclusion increased. @entity4 concentration in duodenal outflow, with the exception of that of @entity2 , reflected intake. The total amount of each @entity4 in ileal outflow increased and the apparent digestibility of most @entity5 decreased with greater amounts of Pruteen in the diet. Apparent digestibility of nucleic acid-N from Pruteen was very high. True digestibility in the small intestine and between mouth and ileum of 3H-labelled milk protein was high and did not differ between dietary treatments. True digestibility of 35S-labelled Pruteen was low for the @entity11 diet and tended to increase linearly as more dietary Pruteen was included. Dry matter concentration in faeces and a high apparent digestibility throughout the whole alimentary tract of @entity8 did not differ between treatments.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Digestion, absorption and utilization of single-cell protein by the preruminant XXXX . The true digestibility of milk and bacterial protein and the apparent digestibility and utilization of their constituent @entity5 .

answer: @entity0