abstract: BACKGROUND AND OBJECTIVES: Infra orbital nerve block is utilized for @entity3 control in @entity0 undergoing @entity12 repair. This study was conducted to compare the effectiveness, @entity11 and opioids for @entity3 relief following cheiloplasty. MATERIALS AND METHODS: Sixty paediatric @entity0 aged 3 months - 13 years undergoing cheiloplasty were selected by simple random sampling and were divided into two groups. All the @entity0 received standardized premedication with @entity9 , were operated upon under general anaesthesia and the block was performed at the end of surgery before reversal. Group B @entity0 were administered bilateral infra orbital nerve block with 0.25% @entity8 (upto 2 mg/kg). Group O @entity0 received @entity13 0.5 mg / kg IV. Postoperatively, the heart rate and respiratory rates were recorded every 15 minutes for the first 60 minutes, half hourly till 4 hours and then at 12 and 24 hours. Behavioural assessment for @entity2 / discomfort was done at intervals of   , 1, 2, 3, 4, 12 and 24 hours. Need for supplementary analgesics and duration between the administration of block/opioid and the first dose of supplementary analgesics were noted. Side effects such as @entity4 and @entity5 , @entity1 , @entity10 and @entity6 during each of these periods were noted. RESULTS: Both the groups were comparable for age, sex, weight and operative time with no statistical difference. The mean duration of @entity7 for infra orbital nerve block was 357.5 minutes i.e. 5 hours 58 minutes and that for opioid was 231 minutes i.e. 3 hours 51 minutes which was significantly lower than the hours of @entity7 provided by the block. Further, at the 4th hour, 76.6% of the @entity0 in Group O required supplementary analgesics, in contrast to only 16.6% in Group B. The incidence of @entity4 and @entity5 and @entity1 was also higher in Group O. CONCLUSION: The results indicate that bilateral infra orbital nerve block provides effective @entity7 in the postoperative period, lasting for 6 hours in comparison to 3   - 4 hours following the administration of intravenous @entity13 , with no major untoward effects.

title: Bilateral Infraorbital Nerve Block Versus Intravenous @entity13 : A Comparative Study on Post-operative XXXX Relief Following Cleft Lip Surgery.

answer: @entity2


abstract: AIMS/HYPOTHESIS: Hyperinsulinaemia is associated with @entity2 but its causal role in the onset of @entity2 remains controversial. In this study, we tested the hypothesis that transient attenuation of diet-induced @entity6 hypersecretion in young @entity1 can provide sustained protection against @entity2 throughout adult life. METHODS: Using 'genetically humanised' @entity1 lacking both alleles of rodent-specific @entity8 , we compared @entity1 heterozygous for the ancestral @entity6 gene @entity7 with @entity7 (+/+) controls. Female @entity8 (-/-): @entity7 (+/-) and @entity8 (-/-): @entity7 (+/+) littermates were fed chow or @entity5 ( @entity5 ). @entity6 secretion, metabolic health variables and body mass/composition were tracked for over 1  year. We examined islet function and adipose transcript levels of adipogenic, lipogenic and lipolytic genes at two time points. RESULTS: In control @entity8 (-/-): @entity7 (+/+) @entity1 , @entity5 resulted in elevated fasting and @entity3 -stimulated @entity6 secretion between 8  weeks and 27  weeks of age. Hyperinsulinaemia was reduced by nearly 50% in @entity8 (-/-): @entity7 (+/-) @entity1 during this period, without lasting adverse effects on @entity3 homeostasis. This corresponded with attenuated @entity4 and adiposity. White adipose tissue from @entity8 (-/-): @entity7 (+/-) @entity1 had fewer large lipid droplets, although transcriptional changes were not detected. Importantly, @entity8 (-/-): @entity7 (+/-) @entity1 remained lighter than @entity8 (-/-): @entity7 (+/+) littermates despite reaching an equivalent degree of hyperinsulinaemia on @entity5 by 52  weeks. CONCLUSIONS/INTERPRETATION: These data demonstrate that attenuation of hyperinsulinaemia in young, growing female @entity1 provides a long-lasting protection against @entity2 . This protection persists despite a late-onset emergence of hyperinsulinaemia in @entity5 -fed @entity8 (-/-): @entity7 (+/-) @entity1 . Given the evolutionary conserved roles of @entity6 , it is possible that suppressing hyperinsulinaemia early in life may have far-reaching consequences on @entity2 in full-grown adult @entity0 .

title: Suppression of hyperinsulinaemia in growing female @entity1 provides long-term protection against XXXX .

answer: @entity2


abstract: AIMS/HYPOTHESIS: Hyperinsulinaemia is associated with @entity2 but its causal role in the onset of @entity2 remains controversial. In this study, we tested the hypothesis that transient attenuation of diet-induced @entity6 hypersecretion in young @entity1 can provide sustained protection against @entity2 throughout adult life. METHODS: Using 'genetically humanised' @entity1 lacking both alleles of rodent-specific @entity8 , we compared @entity1 heterozygous for the ancestral @entity6 gene @entity7 with @entity7 (+/+) controls. Female @entity8 (-/-): @entity7 (+/-) and @entity8 (-/-): @entity7 (+/+) littermates were fed chow or @entity5 ( @entity5 ). @entity6 secretion, metabolic health variables and body mass/composition were tracked for over 1  year. We examined islet function and adipose transcript levels of adipogenic, lipogenic and lipolytic genes at two time points. RESULTS: In control @entity8 (-/-): @entity7 (+/+) @entity1 , @entity5 resulted in elevated fasting and @entity3 -stimulated @entity6 secretion between 8  weeks and 27  weeks of age. Hyperinsulinaemia was reduced by nearly 50% in @entity8 (-/-): @entity7 (+/-) @entity1 during this period, without lasting adverse effects on @entity3 homeostasis. This corresponded with attenuated @entity4 and adiposity. White adipose tissue from @entity8 (-/-): @entity7 (+/-) @entity1 had fewer large lipid droplets, although transcriptional changes were not detected. Importantly, @entity8 (-/-): @entity7 (+/-) @entity1 remained lighter than @entity8 (-/-): @entity7 (+/+) littermates despite reaching an equivalent degree of hyperinsulinaemia on @entity5 by 52  weeks. CONCLUSIONS/INTERPRETATION: These data demonstrate that attenuation of hyperinsulinaemia in young, growing female @entity1 provides a long-lasting protection against @entity2 . This protection persists despite a late-onset emergence of hyperinsulinaemia in @entity5 -fed @entity8 (-/-): @entity7 (+/-) @entity1 . Given the evolutionary conserved roles of @entity6 , it is possible that suppressing hyperinsulinaemia early in life may have far-reaching consequences on @entity2 in full-grown adult @entity0 .

title: Suppression of hyperinsulinaemia in growing female XXXX provides long-term protection against @entity2 .

answer: @entity1


abstract: INTRODUCTION: Corynebacteria have an important place among the commensal flora of the skin and mucous membranes. Except for @entity5 , they were once considered contaminants of mucosa. Recent publications in medical bacteriology have highlighted the importance of several species, such as @entity6 . To the best of our knowledge, we report the first isolation of this strain from urine. CASE PRESENTATION: We report a case of a @entity0 with a @entity3 with @entity6 . We isolated this bacterium from a 52-year-old @entity0 of Wolof ethniticity (an ethnic group in Senegal, West Africa) at the regional hospital of Saint Louis, Senegal. Microscopic examination of his total urine sample showed coryneform Gram-positive bacilli associated with a high leukocyte reaction. After repeated isolation of the corynebacteria in three samples from the @entity0 's urine, it was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The strain was susceptible to antibiotics, except for @entity1 and @entity4 . The potential infectious role of these commensal species in several @entity2 should be taken into consideration. CONCLUSIONS: This case highlights the significant proportion of species in the genus @entity5 other than dyphteriae in the infectious process. The use of mass spectrometry for identification highlights the originality of this work and the importance of these new diagnostic tools that are unavailable in most health facilities of countries with limited resources. We share the results of our method of identification of the isolated bacteria. This case should prompt attention to these rare bacteria, which can cause severe @entity2 .

title: @entity3 with XXXX after urethroplasty stricture of the urethra: a case report.

answer: @entity6


abstract: INTRODUCTION: Corynebacteria have an important place among the commensal flora of the skin and mucous membranes. Except for @entity5 , they were once considered contaminants of mucosa. Recent publications in medical bacteriology have highlighted the importance of several species, such as @entity6 . To the best of our knowledge, we report the first isolation of this strain from urine. CASE PRESENTATION: We report a case of a @entity0 with a @entity3 with @entity6 . We isolated this bacterium from a 52-year-old @entity0 of Wolof ethniticity (an ethnic group in Senegal, West Africa) at the regional hospital of Saint Louis, Senegal. Microscopic examination of his total urine sample showed coryneform Gram-positive bacilli associated with a high leukocyte reaction. After repeated isolation of the corynebacteria in three samples from the @entity0 's urine, it was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The strain was susceptible to antibiotics, except for @entity1 and @entity4 . The potential infectious role of these commensal species in several @entity2 should be taken into consideration. CONCLUSIONS: This case highlights the significant proportion of species in the genus @entity5 other than dyphteriae in the infectious process. The use of mass spectrometry for identification highlights the originality of this work and the importance of these new diagnostic tools that are unavailable in most health facilities of countries with limited resources. We share the results of our method of identification of the isolated bacteria. This case should prompt attention to these rare bacteria, which can cause severe @entity2 .

title: XXXX with @entity6 after urethroplasty stricture of the urethra: a case report.

answer: @entity3


abstract: UNASSIGNED: @entity3 is the most frequent primary @entity4 in adults. Despite treatments including surgery, radiotherapy and chemotherapy by oral @entity5 ( @entity6 ), the prognosis of @entity0 with @entity3 remains very poor. We hypothesized that a @entity7 ( @entity7 ) injectable hydrogel would provide a sustained and local delivery of @entity6 . The hydrogel photopolymerized rapidly (<2min) and presented a viscous modulus (   10kPa). @entity6 release kinetic presented two phases: a linear burst release of 45% of @entity6 during the first 24h, followed by a logarithmic release of 20% over the first week. The in vivo tolerability study showed that the unloaded hydrogel did not induce apoptosis in @entity2 brains nor increased microglial activation. In vivo, the anti- @entity1 efficacy of @entity6 -hydrogel was evaluated on xenograft U87MG @entity1 -bearing @entity2 . The @entity1 weight of @entity2 treated with the photopolymerized @entity6 hydrogel drastically decreased compared with all other groups. Higher apoptosis (located at the center of the @entity1 ) was also observed. The present study demonstrates the potential of a photopolymerizable @entity6 -loaded hydrogel to treat @entity3 .

title: @entity5 -loaded photopolymerizable @entity7 -based hydrogel for the treatment of XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity3 is the most frequent primary @entity4 in adults. Despite treatments including surgery, radiotherapy and chemotherapy by oral @entity5 ( @entity6 ), the prognosis of @entity0 with @entity3 remains very poor. We hypothesized that a @entity7 ( @entity7 ) injectable hydrogel would provide a sustained and local delivery of @entity6 . The hydrogel photopolymerized rapidly (<2min) and presented a viscous modulus (   10kPa). @entity6 release kinetic presented two phases: a linear burst release of 45% of @entity6 during the first 24h, followed by a logarithmic release of 20% over the first week. The in vivo tolerability study showed that the unloaded hydrogel did not induce apoptosis in @entity2 brains nor increased microglial activation. In vivo, the anti- @entity1 efficacy of @entity6 -hydrogel was evaluated on xenograft U87MG @entity1 -bearing @entity2 . The @entity1 weight of @entity2 treated with the photopolymerized @entity6 hydrogel drastically decreased compared with all other groups. Higher apoptosis (located at the center of the @entity1 ) was also observed. The present study demonstrates the potential of a photopolymerizable @entity6 -loaded hydrogel to treat @entity3 .

title: XXXX -loaded photopolymerizable @entity7 -based hydrogel for the treatment of @entity3 .

answer: @entity5


abstract: UNASSIGNED: @entity3 is the most frequent primary @entity4 in adults. Despite treatments including surgery, radiotherapy and chemotherapy by oral @entity5 ( @entity6 ), the prognosis of @entity0 with @entity3 remains very poor. We hypothesized that a @entity7 ( @entity7 ) injectable hydrogel would provide a sustained and local delivery of @entity6 . The hydrogel photopolymerized rapidly (<2min) and presented a viscous modulus (   10kPa). @entity6 release kinetic presented two phases: a linear burst release of 45% of @entity6 during the first 24h, followed by a logarithmic release of 20% over the first week. The in vivo tolerability study showed that the unloaded hydrogel did not induce apoptosis in @entity2 brains nor increased microglial activation. In vivo, the anti- @entity1 efficacy of @entity6 -hydrogel was evaluated on xenograft U87MG @entity1 -bearing @entity2 . The @entity1 weight of @entity2 treated with the photopolymerized @entity6 hydrogel drastically decreased compared with all other groups. Higher apoptosis (located at the center of the @entity1 ) was also observed. The present study demonstrates the potential of a photopolymerizable @entity6 -loaded hydrogel to treat @entity3 .

title: @entity5 -loaded photopolymerizable XXXX -based hydrogel for the treatment of @entity3 .

answer: @entity7


abstract: Fifty-fix constrained total knee replacements (forty Guepar and sixteen Herbert prostheses) were performed in forty-nine severely disabled @entity7 @entity0 and they were followed for two to four years. Seventeen of these knees were operated on to salvage a failed prosthesis. Good relief of @entity1 was achieved in 64 per cent of the knees but there was less improvement in walking and function. The over-all range of motion increased because of a reduction in preoperative @entity6 . The results in the salvage group were less successful than in those @entity0 who underwent a primary operation. Between six months and one year postoperatively, @entity1 had developed in 17 per cent of the fifty-six knees, 9 per cent had walking difficulties, and 7 per cent lost function. @entity1 accounted for the unfavorable @entity1 ratings in over half of the knees. Zonal roentgenographic analysis of each knee indicated high incidences of radiolucent lines at the cement-bone interface (75 per cent), cement-metal lucencies (68 per cent), and @entity8 (73 per cent). Forty-three per cent of the knees showed excessive posterior placement of the prosthesis of more than five millimeters, resulting in @entity6 of as much as 5 degrees. Complications requiring reoperation developed in nine knees (16 per cent). There was one case of loosening and three knees had @entity3 . @entity4 were present in 48 per cent of the knees. The use of either a cemented metal-on-metal hinged knee replacement or a metal-on- @entity5 hinge type of prosthesis was found to result in a relatively high incidence of @entity2 and complications, and did not solve the problem of treating @entity0 with a failed knee prosthesis.

title: Results with the constrained total knee prosthesis in treating severely disabled XXXX and @entity0 with failed total knee replacements.

answer: @entity0


abstract: Fifty-fix constrained total knee replacements (forty Guepar and sixteen Herbert prostheses) were performed in forty-nine severely disabled @entity7 @entity0 and they were followed for two to four years. Seventeen of these knees were operated on to salvage a failed prosthesis. Good relief of @entity1 was achieved in 64 per cent of the knees but there was less improvement in walking and function. The over-all range of motion increased because of a reduction in preoperative @entity6 . The results in the salvage group were less successful than in those @entity0 who underwent a primary operation. Between six months and one year postoperatively, @entity1 had developed in 17 per cent of the fifty-six knees, 9 per cent had walking difficulties, and 7 per cent lost function. @entity1 accounted for the unfavorable @entity1 ratings in over half of the knees. Zonal roentgenographic analysis of each knee indicated high incidences of radiolucent lines at the cement-bone interface (75 per cent), cement-metal lucencies (68 per cent), and @entity8 (73 per cent). Forty-three per cent of the knees showed excessive posterior placement of the prosthesis of more than five millimeters, resulting in @entity6 of as much as 5 degrees. Complications requiring reoperation developed in nine knees (16 per cent). There was one case of loosening and three knees had @entity3 . @entity4 were present in 48 per cent of the knees. The use of either a cemented metal-on-metal hinged knee replacement or a metal-on- @entity5 hinge type of prosthesis was found to result in a relatively high incidence of @entity2 and complications, and did not solve the problem of treating @entity0 with a failed knee prosthesis.

title: Results with the constrained total knee prosthesis in treating severely disabled @entity0 and XXXX with failed total knee replacements.

answer: @entity0


abstract: OBJECTIVES: To explore social, psychological and financial burden on caregivers of chronically diseased @entity0 . METHODS: @entity0 were recruited from ambulatory and hospital areas in pediatrics department following informed consent. Parents who were caregivers of @entity0 18y or below in age with @entity2 were included. Socio-demographic details were collected using a semi structured questionnaire, adapted from Family Burden Interview Schedule (FBIS). The psychological well-being of caregivers was assessed using @entity0 Health Questionnaire (PHQ-9) and Generalized @entity3 (GAD-7). Descriptive analysis and ANOVA was done for comparing mean scores of responses to analyze financial, psychological and social burden across different diagnosis. RESULTS: A total of 204 (89 females:115 males) participated. Only 27% were receiving some benefits from government or hospital side. No @entity5 were reported by 25% caregivers, while 37% reported mild and 38% moderate to severe @entity5 . No @entity3 were reported by 33%, while 50% reported mild and 17% moderate to severe @entity3 . No association was seen between gender of the caregiver and @entity5 . Significantly higher financial and social burden was seen in @entity4 and @entity1 groups vis-a-vis other diseases, being least in @entity6 . Disruption of routine life was highest in @entity1 group caregivers followed by those in @entity4 group. CONCLUSIONS: Most caregivers reported moderate @entity5 and mild to moderate @entity3 . @entity4 caused more social and financial @entity7 . Social and financial burden on families of remaining diseases was comparable.

title: Social, Psychological and Financial Burden on Caregivers of @entity0 with XXXX : A Cross-sectional Study.

answer: @entity2


abstract: OBJECTIVES: To explore social, psychological and financial burden on caregivers of chronically diseased @entity0 . METHODS: @entity0 were recruited from ambulatory and hospital areas in pediatrics department following informed consent. Parents who were caregivers of @entity0 18y or below in age with @entity2 were included. Socio-demographic details were collected using a semi structured questionnaire, adapted from Family Burden Interview Schedule (FBIS). The psychological well-being of caregivers was assessed using @entity0 Health Questionnaire (PHQ-9) and Generalized @entity3 (GAD-7). Descriptive analysis and ANOVA was done for comparing mean scores of responses to analyze financial, psychological and social burden across different diagnosis. RESULTS: A total of 204 (89 females:115 males) participated. Only 27% were receiving some benefits from government or hospital side. No @entity5 were reported by 25% caregivers, while 37% reported mild and 38% moderate to severe @entity5 . No @entity3 were reported by 33%, while 50% reported mild and 17% moderate to severe @entity3 . No association was seen between gender of the caregiver and @entity5 . Significantly higher financial and social burden was seen in @entity4 and @entity1 groups vis-a-vis other diseases, being least in @entity6 . Disruption of routine life was highest in @entity1 group caregivers followed by those in @entity4 group. CONCLUSIONS: Most caregivers reported moderate @entity5 and mild to moderate @entity3 . @entity4 caused more social and financial @entity7 . Social and financial burden on families of remaining diseases was comparable.

title: Social, Psychological and Financial Burden on Caregivers of XXXX with @entity2 : A Cross-sectional Study.

answer: @entity0


abstract: The recombination-activating genes (RAGs) encode for V(D)J recombinases responsible for rearrangements of antigen-receptor genes during T and B cell development, and RAG expression is known to correlate strictly with the process of rearrangement. There have been several studies of @entity2 illustrating biochemical, physiological and immunological properties. Hitherto, there are limited studies on @entity2 focusing molecular phylogenetic analyses, evolutionary traits, and genetic variants in @entity0 populations. Hence, there is a need of a comprehensive study on this topic. In the current report, we have shed light into insights of evolutionary traits and genetic variants of @entity0 @entity2 gene using 1092 genomes from @entity0 populations. Syntenic analyses revealed that two RAG genes are physically linked and conserved on the same locus in head-to-head orientation from sea urchin to @entity0 for about 550 MY. Spliceosomal introns have been in invaded in fishes and sea urchin, whereas gene structures of @entity2 gene from tetrapods remained single exon architecture. We compiled 751 genetic variants in @entity0 @entity2 gene using 1092 @entity0 genomes; where major stockholders of variant classes are 79% single nucleotide polymorphisms (SNPs), 12.2% somatic single @entity1 variants (somatic SNVs) and 6.8% deletion. Out of 267 missense variants, 140 are deleterious mutations. We identified 284 non-coding variants with 94% regulatory in nature.

title: Understanding V(D)J recombination initiator XXXX gene using molecular phylogenetic and genetic variant analyses and upgrading missense and non-coding variants of clinical importance.

answer: @entity2


abstract: BACKGROUND: The advantage of single-port total extra-peritoneal (TEP) @entity1 over the conventional technique is still debatable. Our objective was to compare the outcomes of TEP @entity1 using either a single-port or conventional surgical technique, in two blind randomized groups of @entity0 . METHODS: In this prospective, randomized, double-blind, controlled clinical trial, 100 @entity0 undergoing surgery for unilateral @entity1 were randomized into two groups: One group underwent conventional laparoscopic TEP @entity1 , while the other was selected for single-port TEP repair. Primary endpoint is @entity2 (VAS), while secondary endpoints are recurrence, @entity4 and complications. RESULTS: From 100 @entity0 , 49 underwent single-port @entity3 TEP repair, 50 had conventional three-port TEP @entity3 repair, and one @entity0 declined to participate after randomization. The two groups were comparable in terms of @entity0 demographics and operative findings. Mean operative time was 49.1(  13.8)  min in the conventional group and 54.1(  14.4)  min in the single-port group (p  =  0.08). Mean hospital stay was 19.7(  5.8)  h in the conventional group and 20.5(  6.4)  h in the single-port group (p  =  0.489). No major complications and no recurrence reported at 11-month follow-up. No statistically significant difference noted in @entity2 between the two groups at regular intervals. CONCLUSIONS: The outcomes after laparoscopic TEP @entity1 with a single-port device are similar but not superior to the conventional technique.

title: Single-port versus conventional laparoscopic total extra-peritoneal XXXX : a prospective, randomized, controlled clinical trial.

answer: @entity1


abstract: BACKGROUND: Small intestine @entity1 can be seen in various conditions such as intestinal transplantation. To further understand the pathologic disruption in @entity1 -reperfusion injury, we have developed a method to measure fluid changes in the intestinal lumen of  @entity0 . METHODS: Two 10-cm @entity0 intestine segments were procured, connected to the terminal apertures of a perfusion device, and continuously infused with 3  mL of @entity6 solution (control solution) containing 50   M of @entity3 ( @entity4 )-inulin. The perfusion device consists of concentric chambers that contain the perfused bowel segments, which are maintained at 37  C via @entity5 bath. The individual chamber has four apertures as follows: two fill and/or drain the surrounding @entity6 solution on the blood side of the tissue. The others provide flow of @entity6 solution containing @entity4 -inulin through the lumens. The experimental intestine was infused with the same solution with 100   M of @entity2 . A pump continuously circulated solutions at 6  mL/min. Samples  were collected at 15-min intervals until 150  min and were measured by the nanoflourospectrometer. RESULTS: A mean of 6- M decrease in the @entity4 -inulin concentration in the @entity2 -treated experimental intestine was observed in comparison with that in the control intestine. The @entity4 -inulin count dilution in the experimental intestine is a result of an increase of fluid secretion produced by the effect of @entity2 , with P values <0.0001. CONCLUSIONS: We demonstrate that it is possible to measure luminal fluid changes over time using our new modified perfusion system along with @entity4 -inulin to allow real-time  determinations of fluid and/or electrolyte movement along the small intestine.

title: A new method to measure intestinal secretion using XXXX -inulin in small bowel of @entity0 .

answer: @entity3


abstract: BACKGROUND: Small intestine @entity1 can be seen in various conditions such as intestinal transplantation. To further understand the pathologic disruption in @entity1 -reperfusion injury, we have developed a method to measure fluid changes in the intestinal lumen of  @entity0 . METHODS: Two 10-cm @entity0 intestine segments were procured, connected to the terminal apertures of a perfusion device, and continuously infused with 3  mL of @entity6 solution (control solution) containing 50   M of @entity3 ( @entity4 )-inulin. The perfusion device consists of concentric chambers that contain the perfused bowel segments, which are maintained at 37  C via @entity5 bath. The individual chamber has four apertures as follows: two fill and/or drain the surrounding @entity6 solution on the blood side of the tissue. The others provide flow of @entity6 solution containing @entity4 -inulin through the lumens. The experimental intestine was infused with the same solution with 100   M of @entity2 . A pump continuously circulated solutions at 6  mL/min. Samples  were collected at 15-min intervals until 150  min and were measured by the nanoflourospectrometer. RESULTS: A mean of 6- M decrease in the @entity4 -inulin concentration in the @entity2 -treated experimental intestine was observed in comparison with that in the control intestine. The @entity4 -inulin count dilution in the experimental intestine is a result of an increase of fluid secretion produced by the effect of @entity2 , with P values <0.0001. CONCLUSIONS: We demonstrate that it is possible to measure luminal fluid changes over time using our new modified perfusion system along with @entity4 -inulin to allow real-time  determinations of fluid and/or electrolyte movement along the small intestine.

title: A new method to measure intestinal secretion using @entity3 -inulin in small bowel of XXXX .

answer: @entity0


abstract: BACKGROUND: Drug @entity13 is among the most severe @entity2 and in rare cases it may progress to @entity14 . Herein, we report a case of @entity5 -induced @entity4 with @entity7 and systemic symptoms complicated by @entity14 . CASE REPORT: An 18-year-old @entity0 presented with maculopapular @entity8 associated with cervical lymphadenopahy appearing 3 weeks after treatment with @entity5 . Her hemodynamic status at admission was unstable. Cutaneous examination revealed an itchy maculopapular @entity8 , which was purpuric at certain sites, together with @entity1 . The diagnosis of @entity2 was suggested and was confirmed by histological examination of a skin biopsy. @entity5 was stopped. Two weeks later, however, @entity7 was noted. Further, four days after discontinuation of @entity5 , in view of the laboratory signs of bicytopenia, @entity11 , @entity10 and hyperferritinaemia, as well as the presence of hemophagocytosis in @entity6 , a diagnosis was made of @entity14 complicating a @entity4 with @entity7 and systemic symptoms. Moreover, viral serology tests were negative. The @entity0 was given intravenous immunoglobulin and the outcome was good. DISCUSSION: The literature contains only very few reports of @entity4 with @entity7 and systemic symptoms complicated by @entity14 . The incriminated drugs were @entity9 , @entity12 and @entity3 . To our knowledge, there has only been one report of @entity5 -induced @entity4 with @entity7 and systemic symptoms complicated by @entity14 .

title: [ XXXX -induced DRESS complicated by @entity14 ].

answer: @entity5


abstract: BACKGROUND: Drug @entity13 is among the most severe @entity2 and in rare cases it may progress to @entity14 . Herein, we report a case of @entity5 -induced @entity4 with @entity7 and systemic symptoms complicated by @entity14 . CASE REPORT: An 18-year-old @entity0 presented with maculopapular @entity8 associated with cervical lymphadenopahy appearing 3 weeks after treatment with @entity5 . Her hemodynamic status at admission was unstable. Cutaneous examination revealed an itchy maculopapular @entity8 , which was purpuric at certain sites, together with @entity1 . The diagnosis of @entity2 was suggested and was confirmed by histological examination of a skin biopsy. @entity5 was stopped. Two weeks later, however, @entity7 was noted. Further, four days after discontinuation of @entity5 , in view of the laboratory signs of bicytopenia, @entity11 , @entity10 and hyperferritinaemia, as well as the presence of hemophagocytosis in @entity6 , a diagnosis was made of @entity14 complicating a @entity4 with @entity7 and systemic symptoms. Moreover, viral serology tests were negative. The @entity0 was given intravenous immunoglobulin and the outcome was good. DISCUSSION: The literature contains only very few reports of @entity4 with @entity7 and systemic symptoms complicated by @entity14 . The incriminated drugs were @entity9 , @entity12 and @entity3 . To our knowledge, there has only been one report of @entity5 -induced @entity4 with @entity7 and systemic symptoms complicated by @entity14 .

title: [ @entity5 -induced DRESS complicated by XXXX ].

answer: @entity14


abstract: BACKGROUND: Previous studies reported a preserved ability to cycle in freezers, creating opportunities for restoring mobility and independence. However, use of a bicycle is not always feasible. Here, we investigated the effectiveness of a "walk-bicycle" in reducing freezing of gait ( @entity2 ). METHODS: Eighteen @entity1 @entity0 with @entity2 performed the following tasks, each four times, with and without the walk-bicycle: (1) normal walking; (2) walking with small steps, at normal speed; (3) walking with small steps, as rapidly as possible. RESULTS: Seven @entity0 showed @entity2 during walking without the walk-bicycle. In those @entity0 , the walk-bicycle afforded a 12% reduction of time frozen (p = 0.026). In 11 @entity0 no @entity2 was observed during walking without the walk-bicycle. Two of them showed @entity2 when using the walk-bicycle. CONCLUSIONS: The walk-bicycle may help to reduce @entity2 in some @entity0 , but not in all. Future studies need to evaluate its usefulness in a home environment.

title: The walk-bicycle: A new assistive device for Parkinson's XXXX with freezing of gait?

answer: @entity0


abstract: AIMS: Only limited comparative data exist on the benefits of fluid monitoring (FM) combined with remote monitoring (RM) regarding morbidity and mortality of @entity2 ( @entity2 ) @entity0 . This prospective single-centre randomized pilot study aimed to estimate the influence of RM in combination with FM on @entity2 hospitalizations as well as @entity4 and mortality. METHODS AND RESULTS: @entity0 with standard indication for @entity3 ( @entity3 ) or cardiac resynchronization therapy and defibrillator were implanted with devices capable of RM and FM, and were followed for 15 months. Subjects were randomly allocated to RM including OptiVol and predefined management of alerts (remote group), or standard in-office visits every 3 months (control group). A total of 176 @entity0 (77% male; 66    12 years; left ventricular ejection fraction (LVEF) 32    11%; @entity1 50%; CRT device 50%; primary prevention 85%) were analysed. Cox proportional hazard analysis on the time to first @entity2 -related hospitalization showed a hazard ratio of 1.23 [0.62-2.44] (P = 0.551) favouring the control group. In the remote group, 13 @entity0 (15%) experienced @entity5 vs. 10 @entity0 (11%) in the control group (P = 0.512). The average time to first @entity3 shock was 212    173 days in the remote arm and 212    143 days in the control arm (P = 0.994). The Kaplan-Meier estimate of mortality after 1 year was 8.6% (eight deaths) in the remote group vs. 4.6% in the control group (six deaths; P = 0.502). CONCLUSION: In a single-centre randomized pilot study of RM in combination with FM, no significant influence on @entity2 -related hospitalizations, @entity5 , or mortality was found.

title: A randomized study of remote monitoring and fluid monitoring for the management of XXXX with implanted cardiac arrhythmia devices.

answer: @entity0


abstract: OBJECTIVES: Long term swallowing dysfunction in @entity0 with @entity3 ( @entity3 ) treated with concurrent chemoradiation (CRT) is declining. While the use of intensity modulated radiotherapy (IMRT) is commonly believed to be a potential cause, we hypothesize that the increasing incidence of @entity4 ) related disease may also favorably impact this outcome. MATERIALS AND METHODS: We reviewed 130 HPV+ and 17 HPV- @entity0 with stage III-IV @entity3 treated exclusively with conventional 3-field radiotherapy with chemotherapy between 2002 and 2010. The rates of normal diet, limited diet (significant restrictions in the types of foods eaten, and/or requiring nutritional supplementation for weight maintenance) and @entity2 ( @entity2 ) were compared between HPV+ and HPV- @entity0 . Cox proportional hazards modeling were used to perform univariate analysis (UVA) to examine predictors of a combined endpoint of dietary limitation, which included limited diet and/or @entity2 . These outcomes were also compared to our previously reported cohort of @entity3 @entity0 treated between 1989 and 2002 to assess changes in @entity1 over time given the changing disease epidemiology, in the setting of identical treatment regimens. RESULTS: With a median follow-up of 55months, HPV+ @entity0 more frequently had resumed a normal diet (87% vs. 65%) at last follow up and had lower rates of limited diet (9% vs. 18%) and @entity2 (4% vs. 18%) compared to HPV- @entity0 (p=0.02). HPV status was the only significant predictor of reduced swallowing dysfunction on UVA (HR 0.19; p=0.008). When compared to our 1989-2002 cohort, @entity0 treated between 2002 and 2010 had less @entity2 (7.5% vs. 34%, p<0.001) and dietary limitations (26% vs.46%, p<0.001) at 6months post treatment. CONCLUSIONS: HPV+ @entity0 with @entity3 have reduced late swallowing dysfunction after chemoradiation compared to HPV- @entity0 . The changing epidemiology of @entity3 may play a role in @entity1 reduction in these @entity0 , independent of the increasing use of IMRT.

title: It is not just IMRT: @entity4 related XXXX is associated with better swallowing outcomes after definitive chemoradiotherapy.

answer: @entity3


abstract: OBJECTIVES: Long term swallowing dysfunction in @entity0 with @entity3 ( @entity3 ) treated with concurrent chemoradiation (CRT) is declining. While the use of intensity modulated radiotherapy (IMRT) is commonly believed to be a potential cause, we hypothesize that the increasing incidence of @entity4 ) related disease may also favorably impact this outcome. MATERIALS AND METHODS: We reviewed 130 HPV+ and 17 HPV- @entity0 with stage III-IV @entity3 treated exclusively with conventional 3-field radiotherapy with chemotherapy between 2002 and 2010. The rates of normal diet, limited diet (significant restrictions in the types of foods eaten, and/or requiring nutritional supplementation for weight maintenance) and @entity2 ( @entity2 ) were compared between HPV+ and HPV- @entity0 . Cox proportional hazards modeling were used to perform univariate analysis (UVA) to examine predictors of a combined endpoint of dietary limitation, which included limited diet and/or @entity2 . These outcomes were also compared to our previously reported cohort of @entity3 @entity0 treated between 1989 and 2002 to assess changes in @entity1 over time given the changing disease epidemiology, in the setting of identical treatment regimens. RESULTS: With a median follow-up of 55months, HPV+ @entity0 more frequently had resumed a normal diet (87% vs. 65%) at last follow up and had lower rates of limited diet (9% vs. 18%) and @entity2 (4% vs. 18%) compared to HPV- @entity0 (p=0.02). HPV status was the only significant predictor of reduced swallowing dysfunction on UVA (HR 0.19; p=0.008). When compared to our 1989-2002 cohort, @entity0 treated between 2002 and 2010 had less @entity2 (7.5% vs. 34%, p<0.001) and dietary limitations (26% vs.46%, p<0.001) at 6months post treatment. CONCLUSIONS: HPV+ @entity0 with @entity3 have reduced late swallowing dysfunction after chemoradiation compared to HPV- @entity0 . The changing epidemiology of @entity3 may play a role in @entity1 reduction in these @entity0 , independent of the increasing use of IMRT.

title: It is not just IMRT: XXXX related @entity3 is associated with better swallowing outcomes after definitive chemoradiotherapy.

answer: @entity4


abstract: BACKGROUND: This study describes the incidence and outcomes of European @entity0 requiring renal replacement therapy (RRT) for @entity3 due to antineutrophil cytoplasmic antibody (ANCA)-associated @entity6 (AAV). STUDY DESIGN: Cohort study. SETTING _ @entity0 : 12 renal registries providing individual RRT @entity0 data to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry in 1993-2012 participated. PREDICTOR: Cause of primary @entity2 : AAV (ie, @entity7 with @entity7 [Wegener] and microscopic @entity7 ) versus 3 separate matched control groups without @entity8 ) primary @entity5 , (2) @entity1 , and (3) disease other than @entity1 as the cause of primary @entity2 , including @entity5 (termed "nondiabetes"). OUTCOMES: Incidence, causes of @entity4 , and survival. MEASUREMENTS: ERA-EDTA primary @entity2 codes. RESULTS: 2,511 @entity0 with @entity8 ,755, @entity7 with @entity7 ; 756, microscopic @entity7 ) were identified, representing an incidence of 1.05 per million population (pmp) for @entity7 with @entity7 (predominating in Northern Europe) and 0.45 pmp for microscopic @entity7 (prevailing in Southern Europe). Kidney transplantation was performed in 558 (22.2%) @entity0 with @entity6 . The 10-year probability for survival on RRT after day 91 was 32.5% (95% CI, 29.9%-35.1%) in @entity0 with @entity6 . Survival on RRT after day 91 did not differ between AAV and matched nondiabetes @entity0 . @entity0 and transplant survival after kidney transplantation, adjusted for time period and country, was better in AAV than in matched nondiabetes @entity0 (HRs of 0.81 [95% CI, 0.67-0.99] and 0.82 [95% CI, 0.69-0.96], respectively). LIMITATIONS: No data for extrarenal manifestations, treatment, and relapses. CONCLUSIONS: Geographical differences in the incidence of RRT for @entity3 due to @entity7 with @entity7 and microscopic @entity7 copied their distribution in the general population. Overall survival on RRT after day 91 for @entity0 with AAV was similar to that for @entity0 with nondiabetes diagnoses. Our results suggest that @entity0 with AAV are suitable candidates for kidney transplantation with favorable survival outcomes.

title: Characteristics and Outcomes of @entity7 With XXXX (Wegener) and Microscopic Polyangiitis Requiring Renal Replacement Therapy: Results From the European Renal Association-European Dialysis and Transplant Association Registry.

answer: @entity7


abstract: BACKGROUND: This study describes the incidence and outcomes of European @entity0 requiring renal replacement therapy (RRT) for @entity3 due to antineutrophil cytoplasmic antibody (ANCA)-associated @entity6 (AAV). STUDY DESIGN: Cohort study. SETTING _ @entity0 : 12 renal registries providing individual RRT @entity0 data to the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry in 1993-2012 participated. PREDICTOR: Cause of primary @entity2 : AAV (ie, @entity7 with @entity7 [Wegener] and microscopic @entity7 ) versus 3 separate matched control groups without @entity8 ) primary @entity5 , (2) @entity1 , and (3) disease other than @entity1 as the cause of primary @entity2 , including @entity5 (termed "nondiabetes"). OUTCOMES: Incidence, causes of @entity4 , and survival. MEASUREMENTS: ERA-EDTA primary @entity2 codes. RESULTS: 2,511 @entity0 with @entity8 ,755, @entity7 with @entity7 ; 756, microscopic @entity7 ) were identified, representing an incidence of 1.05 per million population (pmp) for @entity7 with @entity7 (predominating in Northern Europe) and 0.45 pmp for microscopic @entity7 (prevailing in Southern Europe). Kidney transplantation was performed in 558 (22.2%) @entity0 with @entity6 . The 10-year probability for survival on RRT after day 91 was 32.5% (95% CI, 29.9%-35.1%) in @entity0 with @entity6 . Survival on RRT after day 91 did not differ between AAV and matched nondiabetes @entity0 . @entity0 and transplant survival after kidney transplantation, adjusted for time period and country, was better in AAV than in matched nondiabetes @entity0 (HRs of 0.81 [95% CI, 0.67-0.99] and 0.82 [95% CI, 0.69-0.96], respectively). LIMITATIONS: No data for extrarenal manifestations, treatment, and relapses. CONCLUSIONS: Geographical differences in the incidence of RRT for @entity3 due to @entity7 with @entity7 and microscopic @entity7 copied their distribution in the general population. Overall survival on RRT after day 91 for @entity0 with AAV was similar to that for @entity0 with nondiabetes diagnoses. Our results suggest that @entity0 with AAV are suitable candidates for kidney transplantation with favorable survival outcomes.

title: Characteristics and Outcomes of XXXX With @entity7 (Wegener) and Microscopic Polyangiitis Requiring Renal Replacement Therapy: Results From the European Renal Association-European Dialysis and Transplant Association Registry.

answer: @entity7


abstract: BACKGROUND: Little is known about vascular access in @entity0 starting hemodialysis therapy after @entity2 . STUDY DESIGN: Retrospective cohort study. SETTING _ @entity0 : Adult @entity0 (aged  >= 18 years) who started hemodialysis therapy in Ontario, Canada, from January 1, 2001, through December 31, 2010, after @entity2 . PREDICTOR: @entity0 clinical and demographic characteristics. OUTCOMES: Proportion and timing of arteriovenous (AV) vascular access creation (fistula or graft) 12 months prior and up to 24 months after starting hemodialysis therapy. MEASUREMENTS: Event rates and outcome predictors. RESULTS: Our cohort included 683 @entity0 with a mean age of 48 years and >50% with comorbidity index score  < 3. In the 12 months predialysis and 24 months postdialysis, 16% and 47% of @entity0 had an AV access created, respectively. In the postdialysis period, 13%, 26%, and 38% of @entity0 had an AV access creation at 3, 6, and 12 months, respectively. History of @entity3 , @entity1 , and peritoneal dialysis use prior to transplantation were associated with a lower likelihood of AV access creation. LIMITATIONS: Residual selection bias from unmeasured variables beyond the data elements. CONCLUSIONS: In Ontario, AV access creation, both before and after starting hemodialysis therapy, is low in @entity0 with @entity2 despite their being younger and healthier compared to the overall hemodialysis population. This highlights the need for a predialysis care pathway in the transplantation clinic and an active strategy to identify this @entity0 cohort receiving hemodialysis to align modality and access choices.

title: Hemodialysis Arteriovenous Vascular Access Creation After XXXX .

answer: @entity2


abstract: @entity1 (BN) aerogels are porous materials with a continuous three-dimensional network structure. They are attracting increasing attention for a wide range of applications. Here, we report the template-assisted synthesis of BN aerogels by catalyst-free, low-pressure chemical vapor deposition on @entity2 - @entity0 nanotube composite aerogels using @entity3 as the B and N sources with a relatively low temperature of 900   (  )C. The three-dimensional structure of the BN aerogels was achieved through the structural design of @entity0 aerogel templates. The BN aerogels have an ultrahigh specific surface area, ultralow density, excellent oil absorbing ability, and high temperature oxidation resistance. The specific surface area of BN aerogels can reach up to 1051   m(2) g(-1), 2-3 times larger than the reported BN aerogels. The mass density can be as low as 0.6   mg cm(-3), much lower than that of air. The BN aerogels exhibit high hydrophobic properties and can absorb up to 160 times their weight in oil. This is much higher than porous BN nanosheets reported previously. The BN aerogels can be restored for reuse after oil absorption simply by burning them in air. This is because of their high temperature oxidation resistance and suggests broad utility as water treatment tools.

title: Ultralight XXXX aerogels via template-assisted chemical vapor deposition.

answer: @entity1


abstract: PURPOSE: To describe a new modified technique in the treatment of @entity1 ( @entity1 ) using the RetCam 3 digital imaging system - Camera-Assisted Laser photocoagulation and Cryotherapy of the Retina ( @entity2 ). METHODS: From Nov 2011 to Oct 2013, 113 @entity0 were diagnosed with @entity1 . The average post-conceptual age (PCA) at the time of diagnosis was the 35(th) week of PCA; the average birth weight was 1,041 g. According to the ETROP study, the avascular part of the retina of @entity0 with high-risk prethreshold @entity1 was treated with a trans-scleral diode laser or with cryotherapy within 48-72 h after the diagnosis. The intervention was performed under general anaesthesia under the direct visual control of the RetCam 3. RESULTS: The @entity2 technique was used in all 23 @entity0 (46 eyes) diagnosed with high-risk prethreshold @entity1 . The average age of these @entity0 at the time of the intervention was the 38(th) week of PCA. None of the @entity0 had any serious complications during the @entity2 procedure. In contrast to the traditional technique, @entity2 offers many benefits: the image of the retina is real, magnified and not inverted, it shows details of the retina in a high resolution, photo and video documentation is available. Therefore the preoperative, intraoperative and postoperative condition of the retina can be precisely evaluated and compared on a fully standardized basis. CONCLUSIONS: The @entity2 procedure represents a new technique providing greater accuracy when targeting the avascular part of the retina, enables better visualisation and more precise treatment, and reduces the risk of unintended damage to healthy retinal tissue.

title: A new modified technique for the treatment of high - risk prethreshold XXXX under the direct visual control of RetCam 3.

answer: @entity1


abstract: OBJECTIVE: To evaluate the associations between the occurrence of @entity1 ( @entity1 ) in @entity0 and exposures to peri-conceptional multiple nongenetic risk factors. METHODS: For this age-matched case-control study, standardized data were collected from 435 families of @entity0 with CHD and 574 families of non-malformed @entity0 . The questionnaires were conducted on multiple nongenetic risk factors including paternal characteristics and conditions, maternal therapeutic drug exposure, housing renovation, hair perming and dyeing and parental occupational exposure. RESULTS: The CHD @entity0 weighed less than control group (P < 0.01). However two groups had no significant differences in age, height, parental age or heart rate. Educational levels of parents had a negative correlation with CHD. Conotruncal defect and simple ventricular septum defect were the most common @entity1 . Therapeutic drug exposure, @entity2 and occupational exposure all had a high level of correlation with @entity3 (OR = 6.74, OR = 3.73, OR = 2.82 respectively). And ventricular septum defect was associated with therapeutic drug exposure, home decoration, hair perming and dyeing and parental exposure of work environment (OR = 2.77, OR = 1.76, OR = 1.89 respectively). CONCLUSION: Multiple nongenetic risk factors may contribute to the occurrence of CHD.

title: [Clinical epidemiological study of peri-conceptional multiple risk factors and XXXX ].

answer: @entity1


abstract: BACKGROUND: Many different corticosteroid treatment schedules have been used in order to treat refractory @entity2 with encouraging effects on @entity3 reduction in many @entity2 . OBJECTIVE: The objective is to report our experience with a hybrid treatment regimen for @entity3 in @entity0 with @entity2 other than West and @entity7 . We hypothesized that a pulse of @entity1 effectively reduces @entity3 while low-dosage maintenance treatment reduces side effects. The results are compared with results from a review of reported corticosteroid and ACTH treatments. METHODS: In this retrospective observational study, 26 @entity0 diagnosed with @entity2 with @entity3 other than @entity5 and @entity7 were eligible for a treatment regimen consisting of three days intravenous @entity6 (20  mg per kilogram per day) followed by twelve weeks oral @entity4 (0.5  mg per kilogram on alternate days), concluded with a taper phase. Data on effectiveness and side effects were obtained. End-points were the percentages of @entity0 who became @entity3 free or responded well. RESULTS: Twenty-one @entity0 received the study treatment. Nine (43%) responded well and 6 (29%) became @entity3 free. All but one @entity0 had a relapse of @entity3 . Four @entity0 had reversible adverse effects. Data extracted from the literature were consistent with a good response in 48% of 192 @entity0 treated with different corticosteroids and in 69% of 103 @entity0 treated with ACTH. CONCLUSION: This new hybrid therapy of a pulse of intravenous @entity6 and alternate day oral @entity4 is effective with a favourable side effect profile. Results on efficacy and safety justify a randomized controlled trial.

title: Effectiveness of a hybrid corticosteroid treatment regimen on refractory childhood XXXX and a review of other corticosteroid treatments.

answer: @entity3


abstract: BACKGROUND: The intestinal stem cells (ISC) modulation and the role of circulating hematopoietic stem cells (HSC) in @entity3 ( @entity3 ) are poorly understood. Our aim was to investigate the longitudinal modifications in peripheral blood HSC traffic and putative ISC density induced by @entity4 ( @entity4 ) in @entity3 . METHODS: Thirty-one @entity3 @entity0 and 7 controls were enrolled. Circulating CD133(+) and @entity5 (+) HSC were measured by flow cytometry, at enrolment and after 7  days and 1, 3, 6, 12, and 24  months of @entity4 . Endoscopy was performed at diagnosis and repeated at 6, 12, and 24  months following @entity4 . We used the Marsh-Oberhuber score to evaluate the histological severity of @entity1 ; immunohistochemistry was employed to measure the intraepithelial lymphoid infiltrate (IEL, CD3(+) lymphoid cells) and the putative ISC compartment (CD133(+) and Lgr5(+) epithelial cells). RESULTS: At enrolment, circulating HSCs were significantly increased in @entity3 @entity0 and they further augmented during the first week of @entity4 , but progressively decreased afterwards. @entity3 @entity0 presented with villous atrophy, abundant IEL and rare ISC residing at the crypt base. Upon @entity4 , IEL progressively decreased, while ISC density increased, peaking at 12  months. After 24  months of @entity4 , all @entity0 were asymptomatic and their duodenal mucosa was macroscopically and histologically normal. CONCLUSIONS: In active @entity3 @entity0 , the ISC niche is depleted and there is an increased traffic of circulating HSC versus non-coeliac subjects. @entity4 induces a precocious mobilization of circulating HSC, which is followed by the expansion of the local ISC compartment, leading to @entity2 and clinical remission.

title: Circulating hematopoietic stem cells and putative intestinal stem cells in XXXX .

answer: @entity3


abstract: CONTEXT: For @entity0 in palliative care, @entity2 is primarily a result of opioid treatment. Impacts from other factors related to @entity2 in palliative care are rarely studied. OBJECTIVES: The aim was to identify factors related to @entity2 in @entity0 in palliative care, and then to compare these factors between @entity0 with different types of @entity2 and @entity0 without @entity2 . METHODS: Cross-sectional data on @entity2 was collected with a 26-item questionnaire from 485 @entity0 in 38 specialist palliative care units in Sweden. Three different @entity2 groups were used; MC ONLY, PC ONLY, and MC _ PC. Logistic regression analyses were used to calculate odds ratios. RESULTS: @entity0 with <3 defecations/week, MC ONLY, (n  =  36) had higher odds of being hospitalized, bed-restricted, in need of personal assistance for toilet visits, and of having a poor fluid intake. @entity0 with the perception of being constipated, PC ONLY, (n  =  93) had higher odds of having poor appetite, @entity3 , hard stool, more opioid treatment, less laxative treatment and of being more dissatisfied with @entity2 information. @entity0 with both <3 defecations/week and a perception of being constipated, MC _ PC, (n  =  78) had higher odds of having @entity1 . CONCLUSION: There were several significant factors related to @entity2 with higher odds than opioid- treatment, for @entity0 in palliative care, such as; hard stool, @entity1 diagnosis, dissatisfaction with information, low fluid intake, @entity3 , bed restriction, hospitalization, and need of personal assistance for toilet visits.

title: Constipation in specialized palliative care: factors related to XXXX when applying different definitions.

answer: @entity2


abstract: As is well-known, @entity7 plays an essential role in phase III repolarization of cardiac action potentials. Blocking of @entity7 channels can lead to LQTS. Inhibition of the metabolism of CYPs activities may elevate plasma levels, to further increase accumulation of drug on cardiac. The elevated serum levels may however elicit unexpected @entity0 . Therefore, the inhibition tests of @entity7 and CYP are central to the preclinical studies because they may lead to severe @entity1 . @entity6 is widely used as an antibacterial agent and often combined with @entity5 to treat gastropathy. Our objective was to assess @entity1 during the combined use of @entity6 with @entity5 . (1) @entity2 reduced @entity7 currents by accelerated channel inactivation. (2) The combination of @entity6 with @entity2 reduced @entity7 currents, producing an inhibitive effect stronger than use of a single drug alone, due to the high binding affinity for the onset of inactivation. (3) When cells were perfused concomitantly with @entity6 and @entity3 , they showed a stronger inhibitive effect on @entity7 currents by decreasing the time constant for the onset of inactivation. (4) The combined administration of @entity6 with @entity3 had a powerful inhibitive effect on @entity4 activities than use of a single drug alone. Collectively, these results demonstrated that concomitant use of @entity6 with @entity5 may require close monitoring because of potential @entity0 , especially @entity1 .

title: The enhancement of XXXX by concomitant administration of @entity6 and @entity5 .

answer: @entity1


abstract: As is well-known, @entity7 plays an essential role in phase III repolarization of cardiac action potentials. Blocking of @entity7 channels can lead to LQTS. Inhibition of the metabolism of CYPs activities may elevate plasma levels, to further increase accumulation of drug on cardiac. The elevated serum levels may however elicit unexpected @entity0 . Therefore, the inhibition tests of @entity7 and CYP are central to the preclinical studies because they may lead to severe @entity1 . @entity6 is widely used as an antibacterial agent and often combined with @entity5 to treat gastropathy. Our objective was to assess @entity1 during the combined use of @entity6 with @entity5 . (1) @entity2 reduced @entity7 currents by accelerated channel inactivation. (2) The combination of @entity6 with @entity2 reduced @entity7 currents, producing an inhibitive effect stronger than use of a single drug alone, due to the high binding affinity for the onset of inactivation. (3) When cells were perfused concomitantly with @entity6 and @entity3 , they showed a stronger inhibitive effect on @entity7 currents by decreasing the time constant for the onset of inactivation. (4) The combined administration of @entity6 with @entity3 had a powerful inhibitive effect on @entity4 activities than use of a single drug alone. Collectively, these results demonstrated that concomitant use of @entity6 with @entity5 may require close monitoring because of potential @entity0 , especially @entity1 .

title: The enhancement of @entity1 by concomitant administration of XXXX and @entity5 .

answer: @entity6


abstract: As is well-known, @entity7 plays an essential role in phase III repolarization of cardiac action potentials. Blocking of @entity7 channels can lead to LQTS. Inhibition of the metabolism of CYPs activities may elevate plasma levels, to further increase accumulation of drug on cardiac. The elevated serum levels may however elicit unexpected @entity0 . Therefore, the inhibition tests of @entity7 and CYP are central to the preclinical studies because they may lead to severe @entity1 . @entity6 is widely used as an antibacterial agent and often combined with @entity5 to treat gastropathy. Our objective was to assess @entity1 during the combined use of @entity6 with @entity5 . (1) @entity2 reduced @entity7 currents by accelerated channel inactivation. (2) The combination of @entity6 with @entity2 reduced @entity7 currents, producing an inhibitive effect stronger than use of a single drug alone, due to the high binding affinity for the onset of inactivation. (3) When cells were perfused concomitantly with @entity6 and @entity3 , they showed a stronger inhibitive effect on @entity7 currents by decreasing the time constant for the onset of inactivation. (4) The combined administration of @entity6 with @entity3 had a powerful inhibitive effect on @entity4 activities than use of a single drug alone. Collectively, these results demonstrated that concomitant use of @entity6 with @entity5 may require close monitoring because of potential @entity0 , especially @entity1 .

title: The enhancement of @entity1 by concomitant administration of @entity6 and XXXX .

answer: @entity5


abstract: OBJECTIVES: To assess the feasibility of measuring @entity3 ( @entity3 ) in adults with @entity2 due to @entity1 . Secondary objectives are to assess reliability of @entity3 over trials; assess whether @entity0 could sustain treadmill walking at @entity3 ; and compare mean heart rate during sustained treadmill walking to estimated heart rate reserve (HRR). DESIGN: Cross-sectional, single-group design. SETTING: University research laboratory. @entity0 : Volunteer sample of adults (N=8) with impaired walking resulting from @entity1 . INTERVENTIONS: Three submaximal treadmill walking tests on 3 separate days; a 30-minute treadmill walking session on a fourth day. MAIN OUTCOME MEASURES: Gas exchange variables were measured, and 2 independent observers identified @entity3 . Mean heart rate response to treadmill walking at @entity3 was measured and compared with estimated 40% of HRR. RESULTS: @entity3 was measured successfully in 88% of all trials. There was no difference in @entity3 among trials (P=.17). After multiple imputations to account for 3 missing data points, the intraclass correlation coefficient was .87 (95% confidence interval, .80-.95). All @entity0 were able to walk for 20 minutes at @entity3 . Mean    SD heart rate during the session was 66.0%  8.0% of estimated maximal heart rate. There was no significant difference between mean heart rate and estimated HRR values (P=.70). CONCLUSIONS: In adults with impaired walking resulting from @entity1 , @entity3 can be safely measured during submaximal treadmill walking. @entity0 were able to sustain walking at @entity3 , and this value may provide an appropriate stimulus for aerobic exercise prescription in this population.

title: Feasibility of Measuring Ventilatory Threshold in Adults With XXXX -Induced Hemiparesis: Implications for Exercise Prescription.

answer: @entity1


abstract: INTRODUCTION: The consortium for the study of @entity3 (CECaT), including 20 hospitals and one research institute, was recently created in Catalonia (Spain). One of the first initiatives of the group was to perform a descriptive analysis of the characteristics of @entity0 with @entity3 ( @entity3 ). @entity0 AND METHODS: The cohort included 1,855 @entity0 from 11 hospitals treated over a period of 15 years (1998-2012). RESULTS: In this series, 1.470 (79.2%) @entity0 were @entity0 . Mean age was 47.7 (15.7) years old. Age was significantly higher in male than in female @entity0 , 49.3 (15) versus 47.3 (15.8); p=0.02. @entity5 accounted for 88.9% of cases. Mean @entity2 size was 21.5 (16) mm, and was significantly lower in females than in males, 20.1 (14.5) mm and 26.6 (20.3) mm respectively (p<0.001). After a follow-up period of 5.5 (3.7) years, information was available for 1,355 @entity0 , of whom 1065 (78.6%) were free of disease, 239 (17.6%) had no @entity2 persistence, and 51 (3.8) % had died. The risk of persistent or recurrent disease was significantly associated to older age at diagnosis, male gender, larger @entity2 size, lymph node @entity1 at surgery, no signs of @entity4 in the remaining thyroid tissue, and presence of vascular and/or extraglandular invasion. CONCLUSIONS: @entity0 characteristics analyzed are similar to those reported in other parts of the world.

title: A descriptive study of the characteristics of XXXX in Catalonia during the period 1998-2012. The CECaT registry.

answer: @entity3


abstract: UNASSIGNED: Angiogenesis is a highly regulated process orchestrated by the @entity0 system. Heparin/heparan @entity2 (HS) proteoglycans and @entity6 ( @entity6 ) have been identified as co-receptors, yet the mechanisms of action have not been fully defined. In the present study we characterized molecular interactions between receptors and co-receptors, using surface plasmon resonance (SPR) and in vitro binding assays. Additionally, we demonstrate these binding events are relevant to @entity0 activity witihin endothelial cells. We defined interactions and structural requirements for heparin/HS interactions with @entity5 ( @entity5 ), @entity6 , and @entity4 in complex with @entity1 and @entity6 . We demonstrate that these structural requirements are distinct for each interaction. We further show that @entity4 , @entity1 and monomeric @entity6 bind weakly to heparin alone, yet show synergistic binding to heparin when presented together in various combinations. This synergistic binding appears to translate to alterations in @entity0 signaling in endothelial cells. We found that soluble @entity6 increases @entity0 binding and activation of @entity1 and @entity3 in endothelial cells, and that these effects require sulfated HS. These data suggest that the presence of HS/heparin and @entity6 may dictate the specific receptor type activated by @entity0 and ultimately determine the biological output of the system. The ability of co-receptors to fine-tune @entity0 responsiveness suggests the possibility that @entity0 -mediated angiogenesis can be selectively stimulated or inhibited by targeting HS/heparin and @entity6 .

title: Synergistic Binding of XXXX and its Receptors to Heparin Selectively Modulates Complex Affinity.

answer: @entity0


abstract: UNASSIGNED: Chemokines are small, structurally related chemotactic cytokines characterized by the presence of conserved @entity0 residues. In the present study, we identified the cDNA of a CXC chemokine from @entity5 , designated as OfCXCL12. An open reading frame of 297  bp encoded a 98 @entity3 peptide with a putative signal peptide of 23 @entity1 . The CXC family-specific small cytokine domain (SCY), which is highly conserved among vertebrates, was located between residues 29 and 87. The characteristic conserved @entity0 residues in the CXC motif of OfCXCL12 were separated by @entity4 (Y). Similar to other vertebrate CXCL12 proteins, OfCXCL12 also lacked the ELR motif and hence belongs to ELR(-) subfamily. Phylogenetic analysis revealed two distinct clades, consisting of fish and tetrapod CXCL12 homologs. Constitutive expression with significantly higher levels of OfCXCL12 mRNA transcription was detected in immune-related organs, including the head kidney, spleen, and kidney. Infection with bacterial and viral agents led to significant upregulation of mRNA expression in both the head kidney and spleen, in a stimulant-specific manner. Stimulation of peripheral blood leukocytes by the mitogen concanavalin-A significantly induced OfCXCL12 transcription. Results from the present study suggest an important role for OfCXCL12 in immune defense against @entity2 in rock bream.

title: A CXC chemokine gene, CXCL12, from rock bream, XXXX : Molecular characterization and transcriptional profile.

answer: @entity5


abstract: INTRODUCTION: @entity3 ( @entity3 ) are rare functional sex-cord-stromal @entity2 characterized by low @entity1 potential and late relapse, which rarely metastasize to the liver. PRESENTATION OF CASE: A 43-year-old female, who had undergone surgery to treat a @entity5 of the left ovary in 1976, complained of abdominal distention in May 2001. Imaging studies demonstrated masses in the right lobe of the liver, together with massive @entity4 . The @entity0 's bloody @entity4 showed no cytological evidence of @entity1 . A diagnostic laparoscopy was performed, and the biopsy specimen was histologically proven to be a recurrent @entity3 . The @entity0 was successfully treated surgery followed by systemic chemotherapy. Her postoperative course was uneventful and systemic chemotherapy was repeated due to the suspicion of a recurrence in the pelvic cavity. DISCUSSION: @entity3 which are rare @entity1 of the ovary, tend to be associated with late recurrence. Although most recurrences occur within 10 years after the initial diagnosis, there are occasional reports of recurrences after 10 years have been. We experienced the rare case of a @entity0 who relapsed 25 years after the initial diagnosis. CONCLUSION: The long natural history of this disease highlights the importance of extended follow up for @entity5 @entity0 . In addition, aggressive therapy including surgery and chemotherapy may contribute to a @entity0 's long-term prognosis.

title: A recurrent XXXX 25 years after the initial diagnosis: A case report.

answer: @entity5


abstract: OBJECTIVE: To investigate the clinical application value of intraoperative magnetic resonance imaging (iMRI) in large invasive @entity3 surgery. METHODS: A total of 30 @entity0 with large @entity3 underwent microscopic @entity1 resection under the assistance of an iMRI system; 26 cases received surgery through the nasal-transsphenoidal approach, and the remaining four cases received surgery through the pterion approach. iMRI was performed one or two times depending on the need of the surgeon. If a @entity2 was found, further resection was conducted under iMRI guidance. RESULTS: iMRI revealed @entity2 in 12 cases, among which nine cases received further resection. Of these nine cases, iMRI rescanning confirmed complete resection in six cases, and subtotal resection in the remaining three. Overall, 24 cases of @entity1 were totally resected, and six cases were subtotally resected. The total resection rate of @entity1 increased from 60% to 80%. CONCLUSION: iMRI can effectively determine the resection extent of @entity3 . In addition, it provides an objective basis for real-time judgment of surgical outcome, subsequently improving surgical accuracy and safety, and increasing the total @entity1 resection rate.

title: Application of intraoperative magnetic resonance imaging in large invasive XXXX surgery.

answer: @entity3


abstract: INTRODUCTION: Prosthetic teeth size and placement must be in perfect harmony with the bucco-facial structures for a successful and esthetic removable prosthesis. This study aimed to determine among young Senegalese black @entity0 facial index estimating maxillary central incisor width and distance between @entity1 points starting from bizygomatic width. @entity0 AND METHODS: 621 black Senegalese participated to this transversal study. Measurements were made using anthropometric slide caliper and electronic slide caliper. The comparative analysis was carried out by the test t of Student. The correlative analysis used the chi-square test. The risk of error was fixed at 5%. RESULTS: Positive correlations were found between variables. Distance between @entity1 points was significantly (p = 0.000) correlated to bizygomatic width and central incisor width. Using bizygomatic width, the average dividing factors to estimate central incisor width and distance between @entity1 points were respectively 15.13 and 3.75. CONCLUSION: Distance between @entity1 points and central incisor width can be given starting from bizygomatic width, as guide of selecting maxillary anterior prosthetic teeth width.

title: [Relationship between bizygomatic width and the size of maxillary anterior teeth among young Senegalese black XXXX recruited in army].

answer: @entity0


abstract: BACKGROUND: @entity2 ( @entity2 ) affects 6% of community-dwelling older @entity0 . This increases to 60% when non-invasive, continuous blood pressure (BP) monitoring is used, due to identification of transient drops in BP which recover rapidly. AIM: To determine the clinical relevance of these transient orthostatic BP drops. DESIGN: Five-year clinical observational study. METHODS: One hundred three consecutive new @entity0 attending a Falls and @entity3 Clinic in the UK from 1 February 2009 underwent continuous BP monitoring during an active stand. BP profiles were analysed to quantify all reductions in BP, measuring the duration of any drop below diagnostic criteria. Five-year follow-up data were extracted from hospital clinical records to assess clinical outcomes. RESULTS: Systolic BP (sBP) dropped >= 20   mmHg in 76 (74%) individuals, with 65 (63%) having >= 10   mmHg drop in diastolic BP. However, only 22 (21%) cases were diagnosed clinically with @entity2 . A sustained reduction in BP (>= 30   s) had a sensitivity of 0.91 and specificity of 0.88 for a clinical diagnosis of @entity2 , being more accurate than absolute BP reduction alone. A sustained reduction in sBP was associated with greater use of vasopressors (36%, P 0.001) and an independent, significantly greater risk of @entity1 (45% at 5 years, P 0.009). CONCLUSION: An orthostatic reduction in sBP lasting >= 30   s improves accuracy of diagnosis. Moreover, given the significant adverse outcomes with a sustained reduction, clinicians should consider this when diagnosing and treating @entity0 , as transient @entity2 does not appear to be clinically significant.

title: The duration of the orthostatic blood pressure drop is predictive of XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the correlation between diaphragm thickness assessed by ultrasound (US) with respiratory function tests and the diaphragm motor responses, in @entity0 with @entity1 ( @entity1 ). METHODS: 42 consecutive @entity1 @entity0 were studied (11 with bulbar-onset), excluding @entity0 with marked orofacial paresis. Investigation included: revised @entity1 functional rating scale (ALSFRS-R), forced vital capacity (FVC), maximal @entity2 (MVV), maximal inspiratory (MIP) and expiratory (MEP) pressures, nasal inspiratory pressure during sniff (SNIP); peak-to-peak amplitude of the diaphragmatic motor response to phrenic nerve stimulation (Diaphragm- @entity3 ), diaphragmatic thickness measured by ultrasound during maximal inspiration and during maximal expiration. @entity0 were analysed in bulbar or spinal subgroups. Correlations and multiple linear regression models were studied. RESULTS: The mean age at disease onset was 58.4  11.1years and with a mean disease duration of 17.8  13.6months. Ultrasound studies of diaphragm thickness in full inspiration correlated with diaphragm @entity3 in the whole population and in spinal-onset @entity0 ; and were similar in the two groups. Multiple linear modelling showed that FVC, SNIP and MVV were dependent on the change of thickness (p=0.001, 0.001 and 0.020, respectively) and that MIP and MEP were related to diaphragm @entity3 p=0.003 and p=0.025, respectively). CONCLUSION: Diaphragm thickness correlates with Diaphragm- @entity3 , except in bulbar-onset @entity0 . Respiratory tests are dependent on both diaphragm thickness and Diaphragm- @entity3 . SIGNIFICANCE: US thickness of the diaphragm correlates with the number of functional motor units as assessed by the phrenic nerve motor amplitude.

title: Ultrasound for assessment of diaphragm in XXXX .

answer: @entity1


abstract: STUDY DESIGN: Systematic review. OBJECTIVES: The objective of this study is to systematically review the literature for pediatric cases of @entity5 without radiologic abnormality (SCIWORA) to investigate any possible relationship between initial @entity1 and eventual neurologic status. SETTING: A university department of orthopedics. METHODS: Following the preferred reporting items for systemic reviews and meta-analysis (PRISMA) guidelines for systematic review, the databases of PubMed and OvidSP were electronically searched for articles that use individuals under 18 years old, have @entity3 resulting in @entity5 and have no @entity4 or @entity6 on radiographs. When available, the @entity0 ' age, sex, @entity3 and spinal cord level were recorded. Individuals with @entity3 , who had specific information on cervical level and @entity3 , were recorded as well. @entity0 who reported specific magnetic resonance imaging findings and the time from the injury were also reported. When possible, the American @entity7 @entity2 ( @entity2 ) was determined initially after the injury and then at last follow-up. RESULTS: A total of 433 pediatric @entity0 were identified with SCIWORA. The most prevalent @entity3 was sports-related injury cases (39.83%) followed by fall (24.18%) and motor vehicle-related (23.18%) injuries. The mean improvement recorded for all @entity0 was 0.89 @entity2 grades. CONCLUSION: The most common @entity3 was sports-related and @entity3 , which occurred more frequently than other levels. Initial @entity2 grade A showed poorer outcomes in the pediatric population compared with the adult population. Initial presentation of D showed the highest likelihood of no permanent @entity1 ( @entity2 of E).Spinal Cord advance online publication, 14 July 2015; doi:10.1038/sc.2015.110.

title: XXXX without radiologic abnormality in @entity0 : a systematic review.

answer: @entity5


abstract: STUDY DESIGN: Systematic review. OBJECTIVES: The objective of this study is to systematically review the literature for pediatric cases of @entity5 without radiologic abnormality (SCIWORA) to investigate any possible relationship between initial @entity1 and eventual neurologic status. SETTING: A university department of orthopedics. METHODS: Following the preferred reporting items for systemic reviews and meta-analysis (PRISMA) guidelines for systematic review, the databases of PubMed and OvidSP were electronically searched for articles that use individuals under 18 years old, have @entity3 resulting in @entity5 and have no @entity4 or @entity6 on radiographs. When available, the @entity0 ' age, sex, @entity3 and spinal cord level were recorded. Individuals with @entity3 , who had specific information on cervical level and @entity3 , were recorded as well. @entity0 who reported specific magnetic resonance imaging findings and the time from the injury were also reported. When possible, the American @entity7 @entity2 ( @entity2 ) was determined initially after the injury and then at last follow-up. RESULTS: A total of 433 pediatric @entity0 were identified with SCIWORA. The most prevalent @entity3 was sports-related injury cases (39.83%) followed by fall (24.18%) and motor vehicle-related (23.18%) injuries. The mean improvement recorded for all @entity0 was 0.89 @entity2 grades. CONCLUSION: The most common @entity3 was sports-related and @entity3 , which occurred more frequently than other levels. Initial @entity2 grade A showed poorer outcomes in the pediatric population compared with the adult population. Initial presentation of D showed the highest likelihood of no permanent @entity1 ( @entity2 of E).Spinal Cord advance online publication, 14 July 2015; doi:10.1038/sc.2015.110.

title: @entity5 without radiologic abnormality in XXXX : a systematic review.

answer: @entity0


abstract: UNASSIGNED: @entity5 (As) is a widely distributed trace element which is known to be associated with numerous adverse effects on @entity0 beings and animals. @entity7 ( @entity9 ) is an inorganic arsenical-containing toxic compound. The effect of excessive amounts of @entity9 exposure on gastrointestinal tract tissue damage in cocks is still unknown. This study was conducted to investigate the effect of @entity9 exposure on gastrointestinal tract tissue damage in cocks. In total, 72 1-day-old male Hyline cocks were randomly divided into four groups and fed either a commercial diet or an @entity9 supplement diet containing 7.5, 15, and 30  mg/kg @entity9 . The experiment lasted for 90  days and gastrointestinal tract tissue samples (gizzard, glandular stomach, duodenum, jejunum, ileum, cecum, and rectum) were collected at 30, 60, and 90  days. Catalase (CAT), @entity3 ( @entity8 ), and @entity3 peroxidase ( @entity8 -Px) activities; @entity1 ( @entity2 ) contents; and @entity6 radical ( @entity4  )-mediated inhibition were examined. Furthermore, the results demonstrated that @entity2 content in the gastrointestinal tract was increased, while the activities of CAT, @entity8 , and @entity8 -Px and the ability to resist @entity4   was decreased in the @entity9 treatment groups. Extensive damage was observed in the gastrointestinal tract. These findings indicated that @entity9 exposure caused oxidative damage in the gastrointestinal tract of cocks due to alterations in antioxidant enzyme activities and elevation of free radicals.

title: The Role of Oxidative Stress in Gastrointestinal Tract Tissues Induced by XXXX Toxicity in Cocks.

answer: @entity5


abstract: Currently, there is no universally accepted treatment for @entity3 ( @entity3 ), a pathology that can cause @entity1 or @entity4 . Due to the complexity of @entity3 , more than one therapeutic strategy may be necessary to regain lost functions. Therefore, the present study proposes the use of implants of mesoparticles (MPs) of @entity5 / @entity2 (PPy/I) synthesized by plasma for neuroprotection promotion and functional recovery in combination with treadmill training (TT) for neuroplasticity promotion and maintenance of muscle tone. PPy/I films were synthesized by plasma and pulverized to obtain MPs. @entity0 with a @entity3 produced by the NYU impactor were divided into four groups: Vehicle (saline solution); MPs ( @entity6 /I implant); Vehicle-TT (saline solution  +  TT); and MPs-TT (PPy/I implant  +  TT). The vehicle or MPs (30   L) were injected into the lesion site 48  h after a @entity3 . Four days later, TT was carried out 5  days a week for 2  months. Functional recovery was evaluated weekly using the BBB motor scale for 9  weeks and tissue protection using histological and morphometric analysis thereafter. Although the MPs of PPy/I increased nerve tissue preservation (P  =  0.03) and promoted functional recovery (P  =  0.015), combination with TT did not produce better neuroprotection, but significantly improved functional results (P  =  0.000) when comparing with the vehicle group. So, use these therapeutic strategies by separately could stimulate specific mechanisms of neuroprotection and neuroregeneration, but when using together they could mainly potentiate different mechanisms of neuronal plasticity in the preserved spinal cord tissue after a @entity3 and produce a significant functional recovery. The implant of mesoparticles of @entity5 / @entity2 into the injured spinal cord displayed good integration into the nervous tissue without a response of rejection, as well as an increased in the amount of preserved tissue and a better functional recovery than the group without transplant after a @entity3 by contusion in @entity0 . The relevance of the present results is that @entity5 / @entity2 implants were synthesized by plasma instead by conventional chemical or electrochemical methods. Synthesis by plasma modifies physicochemical properties of @entity5 / @entity2 implants, which can be responsible of the histological response and functional results. Furthermore, no additional molecules or trophic factors or cells were added to the implant for obtain such results. Even more, when the implant was used together with physical rehabilitation, better functional recovery was obtained than that observed when these strategies were used by separately.

title: Functional recovery in spinal cord injured @entity0 using @entity5 / XXXX implants and treadmill training.

answer: @entity2


abstract: Currently, there is no universally accepted treatment for @entity3 ( @entity3 ), a pathology that can cause @entity1 or @entity4 . Due to the complexity of @entity3 , more than one therapeutic strategy may be necessary to regain lost functions. Therefore, the present study proposes the use of implants of mesoparticles (MPs) of @entity5 / @entity2 (PPy/I) synthesized by plasma for neuroprotection promotion and functional recovery in combination with treadmill training (TT) for neuroplasticity promotion and maintenance of muscle tone. PPy/I films were synthesized by plasma and pulverized to obtain MPs. @entity0 with a @entity3 produced by the NYU impactor were divided into four groups: Vehicle (saline solution); MPs ( @entity6 /I implant); Vehicle-TT (saline solution  +  TT); and MPs-TT (PPy/I implant  +  TT). The vehicle or MPs (30   L) were injected into the lesion site 48  h after a @entity3 . Four days later, TT was carried out 5  days a week for 2  months. Functional recovery was evaluated weekly using the BBB motor scale for 9  weeks and tissue protection using histological and morphometric analysis thereafter. Although the MPs of PPy/I increased nerve tissue preservation (P  =  0.03) and promoted functional recovery (P  =  0.015), combination with TT did not produce better neuroprotection, but significantly improved functional results (P  =  0.000) when comparing with the vehicle group. So, use these therapeutic strategies by separately could stimulate specific mechanisms of neuroprotection and neuroregeneration, but when using together they could mainly potentiate different mechanisms of neuronal plasticity in the preserved spinal cord tissue after a @entity3 and produce a significant functional recovery. The implant of mesoparticles of @entity5 / @entity2 into the injured spinal cord displayed good integration into the nervous tissue without a response of rejection, as well as an increased in the amount of preserved tissue and a better functional recovery than the group without transplant after a @entity3 by contusion in @entity0 . The relevance of the present results is that @entity5 / @entity2 implants were synthesized by plasma instead by conventional chemical or electrochemical methods. Synthesis by plasma modifies physicochemical properties of @entity5 / @entity2 implants, which can be responsible of the histological response and functional results. Furthermore, no additional molecules or trophic factors or cells were added to the implant for obtain such results. Even more, when the implant was used together with physical rehabilitation, better functional recovery was obtained than that observed when these strategies were used by separately.

title: Functional recovery in spinal cord injured @entity0 using XXXX / @entity2 implants and treadmill training.

answer: @entity5


abstract: Currently, there is no universally accepted treatment for @entity3 ( @entity3 ), a pathology that can cause @entity1 or @entity4 . Due to the complexity of @entity3 , more than one therapeutic strategy may be necessary to regain lost functions. Therefore, the present study proposes the use of implants of mesoparticles (MPs) of @entity5 / @entity2 (PPy/I) synthesized by plasma for neuroprotection promotion and functional recovery in combination with treadmill training (TT) for neuroplasticity promotion and maintenance of muscle tone. PPy/I films were synthesized by plasma and pulverized to obtain MPs. @entity0 with a @entity3 produced by the NYU impactor were divided into four groups: Vehicle (saline solution); MPs ( @entity6 /I implant); Vehicle-TT (saline solution  +  TT); and MPs-TT (PPy/I implant  +  TT). The vehicle or MPs (30   L) were injected into the lesion site 48  h after a @entity3 . Four days later, TT was carried out 5  days a week for 2  months. Functional recovery was evaluated weekly using the BBB motor scale for 9  weeks and tissue protection using histological and morphometric analysis thereafter. Although the MPs of PPy/I increased nerve tissue preservation (P  =  0.03) and promoted functional recovery (P  =  0.015), combination with TT did not produce better neuroprotection, but significantly improved functional results (P  =  0.000) when comparing with the vehicle group. So, use these therapeutic strategies by separately could stimulate specific mechanisms of neuroprotection and neuroregeneration, but when using together they could mainly potentiate different mechanisms of neuronal plasticity in the preserved spinal cord tissue after a @entity3 and produce a significant functional recovery. The implant of mesoparticles of @entity5 / @entity2 into the injured spinal cord displayed good integration into the nervous tissue without a response of rejection, as well as an increased in the amount of preserved tissue and a better functional recovery than the group without transplant after a @entity3 by contusion in @entity0 . The relevance of the present results is that @entity5 / @entity2 implants were synthesized by plasma instead by conventional chemical or electrochemical methods. Synthesis by plasma modifies physicochemical properties of @entity5 / @entity2 implants, which can be responsible of the histological response and functional results. Furthermore, no additional molecules or trophic factors or cells were added to the implant for obtain such results. Even more, when the implant was used together with physical rehabilitation, better functional recovery was obtained than that observed when these strategies were used by separately.

title: Functional recovery in spinal cord injured XXXX using @entity5 / @entity2 implants and treadmill training.

answer: @entity0


abstract: INTRODUCTION: The purpose of this study was a detailed analysis of clinical and radiological results following open fixation of acute-traumatic, displaced anterior glenoid rim @entity3 with bioresorbable pins. MATERIALS AND METHODS: This retrospective study included 17 @entity0 with @entity1 sizes >= 20  %, as directly measured in preoperative sagittal en face CT. The mean @entity1 size was 25.3  % (20-35, SD 4.7). Two or three polylactid pins were used for fixation. Mean age of @entity0 at the time of surgery was 50.1  years (27-71). The mean follow-up period was 6.2  years (2.0-11.1). Follow-up included comprehensive objective and subjective evaluation of shoulder function as well as standard radiographs. RESULTS: The majority of 15/17 @entity0 obtained good or excellent clinical results according to the absolute and normalized Constant score, the Rowe score, the Oxford shoulder score, the simple shoulder test, the shoulder @entity2 and disability index and the subjective shoulder value. Quality of life (SF-36) showed reference values. Mean or subitem values of all outcome measures did not differ from the contralateral, uninjured side. Radiographically, all @entity3 healed without secondary dislocation. Radiological signs of @entity6 developed in two @entity0 and progressed in two other @entity0 . There were no @entity4 . No @entity0 experienced glenohumeral instability or had to undergo revision surgery. CONCLUSIONS: Bioresorbable pin fixation is a feasible and safe method of osteosynthesis for anterior glenoid rim @entity3 up to a @entity1 size of about 35  % and enables immediate active range of motion. Good or excellent clinical outcome can be expected and glenohumeral stability is reliably restored. The most common mid- and long-term complication is occurrence or progression of @entity5 . The major benefits of bioresorbable pin fixation are redundancy of implant removal, minimal risk of @entity4 and early functional rehabilitation.

title: Open fixation of XXXX with bioresorbable pins: analysis of clinical and radiological outcome.

answer: @entity3


abstract: OBJECTIVE: To report on the original surgical management of a @entity0 with severe @entity1 of both legs involving @entity2 of an omentum free @entity5 with an emergency vascular bypass. METHODS: After stabilization of the knee with an external fixator, a femoral-tibial bypass graft was performed to revascularize the leg with the contralateral great saphenous vein. Ten days later, an omentum free @entity5 was used with an end-to-side arterial @entity2 between the right gastroepiploic artery and bypass graft to cover the loss of leg substance. DISCUSSION: @entity2 of a free @entity5 with a single axis exposes the @entity0 to risks of @entity4 and amputation. Lengthening of the arterial pedicle of the @entity5 by venous graft or vascular loop might have allowed for avoidance of connection to the bypass. Nevertheless, the saphenous vein, generally used in these indications, was already harvested. The transitional @entity2 of the @entity5 to the contralateral leg could not be considered because of the leg amputation. End-to-side @entity2 to the bypass presents many advantages: @entity2 with a healthy vessel without @entity3 , the superficial characteristics of the bypass, and lower incongruence of the thickness between the vessels compared with an @entity2 performed directly on the superficial femoral artery. CONCLUSION: A free @entity5 anastomosed to an emergency arterial bypass is a rare situation, which is not without risk, but it is an option that is justified by its technical simplicity. However, it should only be considered in exceptional circumstances.

title: Omentum Free XXXX Anastomosed to Arterial Bypass in Open Knee Dislocation: Case Report and Discussion.

answer: @entity5


abstract: OBJECTIVE: This study explores the associations between lifestyle factors and late and moderate @entity2 (LMPT: 32(+0)-36(+6) weeks' gestation), a relatively under-researched group. STUDY DESIGN: A population-based case-cohort study was undertaken involving 922 LMPT and 965 term (37+ weeks' gestation) singleton live and stillbirths born between 1 September 2009 and 31 December 2010 to @entity0 residing in Leicestershire and Nottinghamshire, UK. Poisson multivariable regression models were fitted to estimate relative risks (RR) of LMPT birth associated with maternal smoking, @entity1 and recreational drug use, and diet. RESULTS: @entity0 who smoked during pregnancy were at 38% increased risk of LMPT birth compared with non-smokers (RR 1.38, 95% CI (1.04 to 1.84)). Low consumption of fruit and vegetables was associated with a 31% increased risk compared with those who reported eating higher consumption levels (RR 1.31 (1.03 to 1.66)). @entity0 who did not have any aspects of a Mediterranean diet were nearly twice as likely to deliver LMPT compared with those whose diet included more Mediterranean characteristics (RR 1.81 (1.04 to 3.14)). @entity0 who smoked and consumed low levels of fruit and vegetables (5% of @entity0 ) were at particularly high risk (RR=1.81 (1.29 to 2.55)). There was no significant effect of @entity1 or recreational drug use on LMPT birth. CONCLUSIONS: Smoking and poor diet during pregnancy, factors that strongly impact on @entity2 , are also important at later gestations and experienced together are associated with an elevated rate of risk. Our findings suggest early cessation of smoking during pregnancy may be an effective strategy to reduce LMPT births.

title: Associations between late and moderately @entity2 and smoking, XXXX , drug use and diet: a population-based case-cohort study.

answer: @entity1


abstract: OBJECTIVE: This study explores the associations between lifestyle factors and late and moderate @entity2 (LMPT: 32(+0)-36(+6) weeks' gestation), a relatively under-researched group. STUDY DESIGN: A population-based case-cohort study was undertaken involving 922 LMPT and 965 term (37+ weeks' gestation) singleton live and stillbirths born between 1 September 2009 and 31 December 2010 to @entity0 residing in Leicestershire and Nottinghamshire, UK. Poisson multivariable regression models were fitted to estimate relative risks (RR) of LMPT birth associated with maternal smoking, @entity1 and recreational drug use, and diet. RESULTS: @entity0 who smoked during pregnancy were at 38% increased risk of LMPT birth compared with non-smokers (RR 1.38, 95% CI (1.04 to 1.84)). Low consumption of fruit and vegetables was associated with a 31% increased risk compared with those who reported eating higher consumption levels (RR 1.31 (1.03 to 1.66)). @entity0 who did not have any aspects of a Mediterranean diet were nearly twice as likely to deliver LMPT compared with those whose diet included more Mediterranean characteristics (RR 1.81 (1.04 to 3.14)). @entity0 who smoked and consumed low levels of fruit and vegetables (5% of @entity0 ) were at particularly high risk (RR=1.81 (1.29 to 2.55)). There was no significant effect of @entity1 or recreational drug use on LMPT birth. CONCLUSIONS: Smoking and poor diet during pregnancy, factors that strongly impact on @entity2 , are also important at later gestations and experienced together are associated with an elevated rate of risk. Our findings suggest early cessation of smoking during pregnancy may be an effective strategy to reduce LMPT births.

title: Associations between late and moderately XXXX and smoking, @entity1 , drug use and diet: a population-based case-cohort study.

answer: @entity2


abstract: @entity8 ( @entity8 ) is a rare, progressive, multi-system, @entity1 of telomere biology, first described in 1906 as the @entity8 . The condition presents with the classic triad of @entity7 , @entity3 . Variable somatic abnormalities may be present; these include pulmonary, gastrointestinal, genitourinary, cerebral, and dental complications. @entity6 eventually develops, progressing to @entity4 . In our @entity0 , the progression of @entity8 did not follow the "classic triad" typically seen in the condition. Here we report the case of a 27-year-old male who had features consistent with this syndrome but who had a normal oral cavity associated with @entity5 for @entity7 and @entity3 were the dominant clinical features. The @entity0 was advised to avoid smoking and severe exposure to the sun, and to return regularly for follow-up. Because all symptoms of this disorder are not necessarily seen collectively in any one @entity0 , physicians should consider it as a probability in all @entity0 showing signs of @entity2 , especially accompanied by @entity5 . Our report emphasizes the fact that not all components of the syndrome need to be present and in all cases of genodermatosis, pleomorphism may be expected with variable clinical manifestations. Even though many variants have been described in literature, sparing of the oral cavity as in our @entity0 is extremely uncommon. Therefore, physicians should be aware of the mucocutaneous manifestation of @entity8 and its diagnosis and refer the @entity0 for better evaluation.

title: @entity8 Without Oral Involvement: A Rare XXXX .

answer: @entity1