abstract: BACKGROUND: Incidence of @entity9 ( @entity9 ) is increasing due to increase in @entity0 life expectancy and prevalence of @entity4 . Vertebroplasty had been traditional treatment for @entity3 , but it neither attempts to restore vertebral body height nor eliminates @entity2 and is associated with a high rate of cement leakage. Balloon kyphoplasty involves introduction of inflatable balloon into the fractured body of vertebra for elevation of the end-plates prior to fixation of the @entity5 with bone cement. This study evaluates short term functional and radiological outcomes of balloon kyphoplasty. The secondary aim is to explore short-term complications of the procedure. MATERIALS AND METHODS: A retrospective study of 199 kyphoplasty procedures in 135 @entity0 from March 2009 to March 2012 were evaluated with short form-36 (SF-36) score, visual analogue scale (VAS), detailed neurological and radiological evaluations. The mean followup was 18 months (range 12-20 months). Statistical analysis including paired sample t-test was done with statistical package for social sciences. RESULTS: Statistically significant improvements in SF-36 (from 34.29 to 48.53, an improvement of 14.24, standard deviation (SD) - 20.08 P < 0.0001), VAS (drop of 4.49, from 6.74 to 2.24, SD - 1.44, P < 0.0001), percentage restoration of lost vertebral height (from 30.62% to 16.19%, improvement of 14.43%, SD - 15.37, P < 0.0001) and kyphotic angle correction (from 17.41   to 10.59  , improvement of 6.82, SD - 7.26  , P < 0.0001) were noted postoperatively. Six @entity0 had @entity7 , 65 had cement leak and three had adjacent level @entity5 which required repeat kyphoplasty later. One @entity0 with history of @entity6 had @entity8 during the procedure. No @entity0 had @entity1 in the followup period. CONCLUSIONS: Kyphoplasty is a safe and effective treatment for @entity9 . It improves physical function, reduces @entity3 and corrects @entity2 .

title: Outcome of XXXX .

answer: @entity9


abstract: This chapter focused on three key regulators of PGC survival and proliferation; @entity3 , @entity5 , and @entity2 . The survival of all animal cells may require multiple polypeptide factors and PGCs seem to be no exception (Fig. 7). A number of lines of evidence suggest that membrane-bound forms of @entity3 may be required for PGC survival. These data suggest an exquisite mechanism for controlling both PGC survival and migration. Thus PGCs that stray from the normal migratory pathway might be eliminated through programmed cell death. @entity3 , together with @entity5 , can stimulate PGC proliferation in culture and it seems likely that @entity5 or a related cytokine may function in vivo to regulate PGC survival and proliferation. Animals doubly deficient in @entity5 and its relatives may soon allow the roles of these cytokines in PGC development to be determined. Although @entity2 is a potent PGC mitogen in vitro, whether PGCs ever encounter @entity2 in vivo remains questionable since in culture it alters both the proliferative and developmental potential of PGCs. @entity1 or @entity4 may be important negative regulators of PGC development, and @entity0 lacking these factors should allow their role in PGC development to be assessed.

title: Growth factor regulation of XXXX primordial germ cell development.

answer: @entity0


abstract: BACKGROUND: Percutaneous lung biopsy is now a common procedure in pulmonary medicine, and several different techniques are in use. The most common has been the use of a fine needle under computed tomography (CT) guidance combined with the trucut needle for histology. AIM: To evaluate the efficacy of fine needle aspiration cytology (FNAC) and immunocytochemistry in comparison with trucut biopsy and immunohistochemistry in @entity0 with localized intrathoracic lesions suspicious for @entity2 . MATERIALS AND METHODS: Eighty @entity0 with localized mass lesions in the lung on imaging (chest radiograph/CT) were selected for this study over a period of 1 year. FNAC was carried out by a 22 G spinal needle after localization of the mass in the CT scan followed by guided trucut biopsy. Immunocytochemistry and immunohistochemistry were performed as and when required. RESULTS: The mean age of our study population was 57.6 years and the M:F ratio was 4.2:1. Majority of the lesions were peripheral and in the right lung. @entity4 was most prevalent (49%), followed by @entity5 and @entity7 . Cyto-histopathological concordance was seen in 60 cases (75%). The highest rate of concordance was seen in @entity7 (83.3%). The overall sensitivity of FNAC in distinguishing @entity3 from benign lesions was 84.2% and the specificity was 100%. The sensitivity of cytology in diagnosing @entity7 was 83.3% and of @entity7 was 65.38%. Immunocytochemistry was carried out in 34 cases, all of which were followed by immunohistochemistry. Cyto-histopathological concordance was noted in 31 of these cases (91.2%). We used the standard panel of four markers ( @entity9 , @entity10 , @entity8 and @entity6 ) for all selected cases. CONCLUSION: Cytology along with immunocytochemistry is highly effective in diagnosing and categorizing @entity1 , producing comparable results to trucut biopsy and immunohistochemistry.

title: Comparative study of cytology and immunocytochemistry with trucut biopsy and immunohistochemistry in diagnosis of XXXX : A prospective study.

answer: @entity3


abstract: OBJECTIVES: The aim of this study was to determine the relation between autonomic control of heart rate and the spontaneous occurrence and inducibility of @entity3 in @entity0 with @entity1 . BACKGROUND: Low heart rate variability increases the risk of arrhythmic events. It is not known whether impaired autonomic heart rate control reflects alterations in functional factors that contribute to the initiation of spontaneous @entity3 or whether it is the consequence of an anatomic substrate for reentrant @entity2 . METHODS: Fifty-four @entity0 with @entity1 with a history of sustained @entity4 (n = 25) or @entity5 (n = 29) were studied by 24-h ambulatory electrocardiographic recording and by programmed electrical stimulation. Heart rate variability was compared among the @entity0 with and without spontaneous @entity3 and with and without inducibility of sustained @entity4 . RESULTS: Eight @entity0 had a total of 21 episodes of sustained @entity4 on Holter recordings. Standard deviation of RR intervals and low frequency and very low frequency components of heart rate variability were significantly blunted in @entity0 with sustained @entity4 compared with those without repetitive @entity6 (p < 0.05, p < 0.01 and p < 0.05, respectively). However, no significant alterations were observed in heart rate variability before the onset of 21 episodes of sustained @entity4 . Heart rate variability did not differ between the @entity0 with or without nonsustained episodes of @entity4 . In @entity0 with frequent @entity6 , low frequency and very low frequency power components were significantly blunted compared with those with infrequent @entity6 (p < 0.01 and p < 0.001, respectively). Heart rate variability did not differ significantly between the @entity0 with and without inducible sustained @entity4 . CONCLUSIONS: Impaired very low and low frequency oscillation of heart rate reflects susceptibility to the spontaneous occurrence of @entity3 but may not reflect the instantaneous triggers for life-threatening @entity3 or a specific marker of the arrhythmic substrate for @entity4 .

title: Relation between heart rate variability and spontaneous and induced XXXX in @entity0 with @entity1 .

answer: @entity3


abstract: OBJECTIVES: The aim of this study was to determine the relation between autonomic control of heart rate and the spontaneous occurrence and inducibility of @entity3 in @entity0 with @entity1 . BACKGROUND: Low heart rate variability increases the risk of arrhythmic events. It is not known whether impaired autonomic heart rate control reflects alterations in functional factors that contribute to the initiation of spontaneous @entity3 or whether it is the consequence of an anatomic substrate for reentrant @entity2 . METHODS: Fifty-four @entity0 with @entity1 with a history of sustained @entity4 (n = 25) or @entity5 (n = 29) were studied by 24-h ambulatory electrocardiographic recording and by programmed electrical stimulation. Heart rate variability was compared among the @entity0 with and without spontaneous @entity3 and with and without inducibility of sustained @entity4 . RESULTS: Eight @entity0 had a total of 21 episodes of sustained @entity4 on Holter recordings. Standard deviation of RR intervals and low frequency and very low frequency components of heart rate variability were significantly blunted in @entity0 with sustained @entity4 compared with those without repetitive @entity6 (p < 0.05, p < 0.01 and p < 0.05, respectively). However, no significant alterations were observed in heart rate variability before the onset of 21 episodes of sustained @entity4 . Heart rate variability did not differ between the @entity0 with or without nonsustained episodes of @entity4 . In @entity0 with frequent @entity6 , low frequency and very low frequency power components were significantly blunted compared with those with infrequent @entity6 (p < 0.01 and p < 0.001, respectively). Heart rate variability did not differ significantly between the @entity0 with and without inducible sustained @entity4 . CONCLUSIONS: Impaired very low and low frequency oscillation of heart rate reflects susceptibility to the spontaneous occurrence of @entity3 but may not reflect the instantaneous triggers for life-threatening @entity3 or a specific marker of the arrhythmic substrate for @entity4 .

title: Relation between heart rate variability and spontaneous and induced @entity3 in @entity0 with XXXX .

answer: @entity1


abstract: OBJECTIVES: The aim of this study was to determine the relation between autonomic control of heart rate and the spontaneous occurrence and inducibility of @entity3 in @entity0 with @entity1 . BACKGROUND: Low heart rate variability increases the risk of arrhythmic events. It is not known whether impaired autonomic heart rate control reflects alterations in functional factors that contribute to the initiation of spontaneous @entity3 or whether it is the consequence of an anatomic substrate for reentrant @entity2 . METHODS: Fifty-four @entity0 with @entity1 with a history of sustained @entity4 (n = 25) or @entity5 (n = 29) were studied by 24-h ambulatory electrocardiographic recording and by programmed electrical stimulation. Heart rate variability was compared among the @entity0 with and without spontaneous @entity3 and with and without inducibility of sustained @entity4 . RESULTS: Eight @entity0 had a total of 21 episodes of sustained @entity4 on Holter recordings. Standard deviation of RR intervals and low frequency and very low frequency components of heart rate variability were significantly blunted in @entity0 with sustained @entity4 compared with those without repetitive @entity6 (p < 0.05, p < 0.01 and p < 0.05, respectively). However, no significant alterations were observed in heart rate variability before the onset of 21 episodes of sustained @entity4 . Heart rate variability did not differ between the @entity0 with or without nonsustained episodes of @entity4 . In @entity0 with frequent @entity6 , low frequency and very low frequency power components were significantly blunted compared with those with infrequent @entity6 (p < 0.01 and p < 0.001, respectively). Heart rate variability did not differ significantly between the @entity0 with and without inducible sustained @entity4 . CONCLUSIONS: Impaired very low and low frequency oscillation of heart rate reflects susceptibility to the spontaneous occurrence of @entity3 but may not reflect the instantaneous triggers for life-threatening @entity3 or a specific marker of the arrhythmic substrate for @entity4 .

title: Relation between heart rate variability and spontaneous and induced @entity3 in XXXX with @entity1 .

answer: @entity0


abstract: BACKGROUND: Cytology of the endometrium is an underused technique in diagnostic pathology. It has been used in the past for @entity2 . Only few studies have used cytology in the diagnosis of dysfunctional uterine @entity1 (DUB). Endometrial imprint cytology has been rarely used except for application of immunocytochemistry in diagnosis of @entity2 . AIM: The present study was conducted to evaluate whether it is possible to assign histopathology-like diagnosis by imprint cytology and also to evaluate its usefulness in the assessment of @entity0 of dysfunctional uterine @entity1 of low clinical suspicion. MATERIALS AND METHODS: Imprint smears were made from 93 curettage materials during a study of DUB. Blinded analysis of imprint smears was performed by using McKenzie's criteria and some criteria devised for the requirements of this study. Results of cytology were correlated with histopathology. Statistical analysis was carried out by GraphpadInStat Demo. RESULTS: Majority of the patterns classifiable in histopathology could also be classified in this study on imprint cytology. The overall sensitivity and specificity of cytology in the detection of endometrial patterns in DUB @entity0 were 91.23% and 83.87%, respectively, although the sensitivities and specificities differ according to the phase of endometrium. CONCLUSION: Histopathology-like categories can be assigned on imprint smears in the diagnosis of DUB. Endometrial imprint cytology can be helpful in centers where histopathology laboratories are not available and even in well-established institutes. It is possible to improve the sensitivity and specificity with better imprinting techniques.

title: Histopathology-like categories based on endometrial imprint cytology in dysfunctional uterine XXXX .

answer: @entity1


abstract: T cell depletion of donor bone marrow can prevent @entity2 ( @entity2 ) in @entity0 and @entity1 marrow graft recipients. However, engraftment in the recipient may be compromised as a consequence of donor marrow T cell depletion. The effect of recombinant @entity1 granulocyte/macrophage colony-stimulating factor (rmu @entity3 ) on engraftment and hematologic reconstitution was evaluated in a @entity1 allogeneic bone marrow transplantation (BMT) model involving T cell depletion of marrow. Before transplantation into irradiated @entity1 differing at major and minor histocompatibility loci, rmu @entity3 was preincubated with T cell-depleted donor marrow. When low degrees of engraftment were noted in control recipients, treatment of donor marrow with high concentrations of rmu @entity3 led to enhanced engraftment. Ex vivo donor graft incubation with rmu @entity3 or a single in vivo injection of rmu @entity3 were both effective means of promoting engraftment. When the engraftment rate in control recipients was high, rmu @entity3 did not have an identifiable effect. Only slight increases in hematologic recovery were detected regardless of the rate of engraftment. Neither post-BMT survival nor marrow stem cell capacity was affected by rmu @entity3 incubation. Furthermore, growth factor administration did not have a significant effect on the incidence of @entity2 in recipients of non-T cell-depleted bone marrow splenocyte preparations. In vitro natural killer-mediated target cell lysis was not altered by incubation of effector cells with rmu @entity3 . These results demonstrate the potential of ex vivo rmu @entity3 treatment of donor marrow to facilitate engraftment across extensive histo-compatibility barriers.

title: Augmentation of donor bone marrow engraftment in histoincompatible XXXX recipients by granulocyte/macrophage colony-stimulating factor.

answer: @entity1


abstract: Plasma insulin-like growth factor-I ( @entity2 ) levels are inversely correlated with @entity4 and low density lipoprotein (LDL) @entity1 in @entity0 . To identify a molecular basis for this observation, the effects of @entity2 on @entity3 expression in fibroblasts were studied. @entity2 increased LDL receptors in cultured @entity0 skin fibroblasts at concentrations greater than 25 ng/ml. However, @entity2 effects were not easily quantitated due to secretion of inhibitory IGF-binding proteins by the cells. To circumvent this difficulty, QAYL, an @entity2 analog that binds to the @entity5 but not to IGF-binding proteins, was used. QAYL increased @entity3 number 56-72% with half-maximum effect at 0.6 ng/ml. alpha-IR3, a monoclonal antibody directed toward the @entity5 , blocked this effect. QAYL treatment increased synthesis of @entity3 protein without increasing @entity3 mRNA levels or altering protein stability. Both QAYL and @entity2 increased LDL receptors prominently in cells that had been treated with physiological amounts of LDL @entity1 . @entity2 , acting through the @entity5 and modulated by IGF-binding proteins, may contribute to the regulation of LDL metabolism by increasing translation of @entity3 message.

title: Increased XXXX expression mediated through the insulin-like growth factor-I receptor in cultured fibroblasts.

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) afflict around one billion individuals in the poorest parts of the world with many more at risk. @entity6 is one of the most prevalent of the infections and causes significant morbidity in those who suffer the clinical conditions, particularly @entity7 and hydrocele. @entity2 has been recognised as a prevalent disability in those with the disease because of the stigmatising nature of the condition. No estimates of the burden of @entity2 of any neglected @entity1 have been undertaken to date despite the recognition that such diseases have major consequences for mental health not only for @entity0 but also their caregivers. METHODS: We developed a mathematical model to calculate the burden of Disability- Adjusted Life Years (DALY) attributable to @entity2 in @entity6 and that of their caregivers using standard methods for calculating DALYs. Estimates of numbers with clinical disease was based on published estimates in 2012 and the numbers with @entity2 from the available literature. RESULTS: We calculated that the burden of @entity2 in @entity9 @entity0 was 5.09 million disability-adjusted life years (DALYs) and 229,537 DALYs attributable to their caregivers. These figures are around twice that of 2.78 million DALYs attributed to @entity9 by the Global Burden of Disease study of 2010. CONCLUSIONS: @entity6 and other neglected @entity1 , notably Buruli Ulcer, @entity8 , @entity5 , yaws, @entity10 and @entity11 cause significant co morbidity associated with @entity3 in @entity0 . Studies to assess the prevalence of the burden of this co-morbidity should be incorporated into any future assessment of the Global Burden of neglected @entity1 . The prevalence of @entity2 in caregivers who support those who suffer from these conditions is required. Such assessments are critical for neglected @entity1 which have such a huge global prevalence and thus will contribute a significant burden of co-morbidity attributable to @entity3 .

title: The burden of mental health in XXXX .

answer: @entity6


abstract: Complications involving the colon occurred in 28 of 325 @entity0 who received renal transplants. @entity11 , the most common complication, affected 15 @entity0 , two of whom required surgery. Three instances of @entity8 were complicated by free perforation in two cases, and by @entity9 in one. @entity4 occurred in two cases. The other complications were @entity2 (from @entity10 or @entity7 ), nonspecific @entity6 , and @entity1 . Spontaneous colonic perforation did not occur. Two thirds of the @entity5 occurred within 30 days after transplantation. All cases of @entity3 , however, occurred later than one month after transplantation. It is concluded that @entity11 is the most common @entity5 in renal transplant recipients, that it usually occurs early, and that it carries a good prognosis. @entity3 occurred later in this series and were treated successfully. All cases of @entity1 were part of terminal multiorgan system failure.

title: XXXX in renal transplant recipients.

answer: @entity5


abstract: A study was undertaken to compare the age, sex, preoperative diagnosis, and operative findings of @entity0 who had @entity4 with @entity0 who had @entity5 . The study consisted of an analysis of 316 case reports and collective reviews of @entity4 that were reported in the literature between 1960 and 1985. The mean age of @entity0 with this disease was 57.1 years and the male-to-female ratio for @entity4 was 1.4:1. Only rarely was a malignancy suspected, as 68 percent of the @entity0 presented with signs and symptoms of @entity2 . The @entity1 was perforated in 55 percent of @entity0 , making it the most frequently perforating @entity3 of the entire gastrointestinal tract. One half of these perforations were localized as abscesses. The presence of perforation did not necessarily predispose a poor prognosis. Synchronous appendiceal and other @entity5 occurred in 2.7 percent of @entity0 . @entity6 occurred as a presenting feature in 5.6 percent of @entity0 and was generally a poor prognostic indicator. @entity3 peritonei was found at initial exploration in 10.3 percent of @entity0 and these @entity0 rarely survived one year.

title: A 25-year review of XXXX . A frequently perforating @entity3 .

answer: @entity4


abstract: A study was undertaken to compare the age, sex, preoperative diagnosis, and operative findings of @entity0 who had @entity4 with @entity0 who had @entity5 . The study consisted of an analysis of 316 case reports and collective reviews of @entity4 that were reported in the literature between 1960 and 1985. The mean age of @entity0 with this disease was 57.1 years and the male-to-female ratio for @entity4 was 1.4:1. Only rarely was a malignancy suspected, as 68 percent of the @entity0 presented with signs and symptoms of @entity2 . The @entity1 was perforated in 55 percent of @entity0 , making it the most frequently perforating @entity3 of the entire gastrointestinal tract. One half of these perforations were localized as abscesses. The presence of perforation did not necessarily predispose a poor prognosis. Synchronous appendiceal and other @entity5 occurred in 2.7 percent of @entity0 . @entity6 occurred as a presenting feature in 5.6 percent of @entity0 and was generally a poor prognostic indicator. @entity3 peritonei was found at initial exploration in 10.3 percent of @entity0 and these @entity0 rarely survived one year.

title: A 25-year review of @entity4 . A frequently perforating XXXX .

answer: @entity3


abstract: @entity5 ( @entity6 ), a derivative of @entity8 has been most commonly used as an ingredient of oxidative hair dye and permanent tattoos. We have studied the phototoxic potential of @entity6 under ambient ultraviolet radiation. @entity6 is photodegraded and form a novel photoproduct under UV A exposure. @entity6 shows a concentration dependent decrease in cell viability of @entity0 Keratinocyte cells (HaCaT) through @entity1 and NRU test. Significant intracellular ROS generation was measured by @entity7 assay. It caused an oxidative DNA damage via single stranded DNA breaks, micronuclei and CPD formation. Both lysosome and mitochondria is main target for @entity6 induced apoptosis which was proved through lysosomal destabilization and release of @entity2 by immunofluorescence, real time PCR and western blot analysis. @entity2 process @entity4 to active tBID which induces the release of @entity3 from mitochondria. Mitochondrial depolarization was reported through transmission electron microscopy. The cathepsin inhibitor reduced the release of @entity3 in @entity6 treated cells. Thus study suggests that @entity6 leads to apoptosis via the involvement of lysosome and mitochondria both under ambient UV radiation. Therefore, photosensitizing nature of hair dye ingredients should be tested before coming to market as a cosmetic product for the safety of @entity0 beings.

title: Involvement of @entity2 in mitochondrial apoptosis by XXXX under ambient UV radiation.

answer: @entity5


abstract: @entity5 ( @entity6 ), a derivative of @entity8 has been most commonly used as an ingredient of oxidative hair dye and permanent tattoos. We have studied the phototoxic potential of @entity6 under ambient ultraviolet radiation. @entity6 is photodegraded and form a novel photoproduct under UV A exposure. @entity6 shows a concentration dependent decrease in cell viability of @entity0 Keratinocyte cells (HaCaT) through @entity1 and NRU test. Significant intracellular ROS generation was measured by @entity7 assay. It caused an oxidative DNA damage via single stranded DNA breaks, micronuclei and CPD formation. Both lysosome and mitochondria is main target for @entity6 induced apoptosis which was proved through lysosomal destabilization and release of @entity2 by immunofluorescence, real time PCR and western blot analysis. @entity2 process @entity4 to active tBID which induces the release of @entity3 from mitochondria. Mitochondrial depolarization was reported through transmission electron microscopy. The cathepsin inhibitor reduced the release of @entity3 in @entity6 treated cells. Thus study suggests that @entity6 leads to apoptosis via the involvement of lysosome and mitochondria both under ambient UV radiation. Therefore, photosensitizing nature of hair dye ingredients should be tested before coming to market as a cosmetic product for the safety of @entity0 beings.

title: Involvement of XXXX in mitochondrial apoptosis by @entity5 under ambient UV radiation.

answer: @entity2


abstract: A @entity0 with a delayed aorto-right ventricular fistula and @entity7 after penetrating @entity3 is reported, and 17 similar additional cases from the literature reviewed. By examining the aortic root of adults with normal cardiac anatomy at autopsy, we defined the target area for these injuries as a 2 X 2 cm contact surface between the aorta above the right coronary cusp and the right ventricular outflow tract below the pulmonary valve. Five of the 18 @entity0 required emergency exploration due to @entity8 . Life-threatening sequelae ( @entity5 and @entity9 ) result from the external injury rather than the intracardiac component. @entity1 is most commonly manifested as the delayed recognition of a cardiac murmur and some degree of @entity6 , and when these appear one must suspect @entity3 . We recommend cardiac catheterization and elective repair, maintaining control of both ends of the @entity4 with bolstered suture. @entity7 can often be primarily repaired. @entity0 with combination aortic valve and @entity3 , more so than those with a single @entity2 , fail with nonoperative management. Of the 18 @entity0 , 17 underwent surgery. One of these died: the others did well during short-term followup (less than 1 year).

title: XXXX with @entity7 from penetrating @entity3 .

answer: @entity4


abstract: A @entity0 with a delayed aorto-right ventricular fistula and @entity7 after penetrating @entity3 is reported, and 17 similar additional cases from the literature reviewed. By examining the aortic root of adults with normal cardiac anatomy at autopsy, we defined the target area for these injuries as a 2 X 2 cm contact surface between the aorta above the right coronary cusp and the right ventricular outflow tract below the pulmonary valve. Five of the 18 @entity0 required emergency exploration due to @entity8 . Life-threatening sequelae ( @entity5 and @entity9 ) result from the external injury rather than the intracardiac component. @entity1 is most commonly manifested as the delayed recognition of a cardiac murmur and some degree of @entity6 , and when these appear one must suspect @entity3 . We recommend cardiac catheterization and elective repair, maintaining control of both ends of the @entity4 with bolstered suture. @entity7 can often be primarily repaired. @entity0 with combination aortic valve and @entity3 , more so than those with a single @entity2 , fail with nonoperative management. Of the 18 @entity0 , 17 underwent surgery. One of these died: the others did well during short-term followup (less than 1 year).

title: @entity4 with XXXX from penetrating @entity3 .

answer: @entity7


abstract: A @entity0 with a delayed aorto-right ventricular fistula and @entity7 after penetrating @entity3 is reported, and 17 similar additional cases from the literature reviewed. By examining the aortic root of adults with normal cardiac anatomy at autopsy, we defined the target area for these injuries as a 2 X 2 cm contact surface between the aorta above the right coronary cusp and the right ventricular outflow tract below the pulmonary valve. Five of the 18 @entity0 required emergency exploration due to @entity8 . Life-threatening sequelae ( @entity5 and @entity9 ) result from the external injury rather than the intracardiac component. @entity1 is most commonly manifested as the delayed recognition of a cardiac murmur and some degree of @entity6 , and when these appear one must suspect @entity3 . We recommend cardiac catheterization and elective repair, maintaining control of both ends of the @entity4 with bolstered suture. @entity7 can often be primarily repaired. @entity0 with combination aortic valve and @entity3 , more so than those with a single @entity2 , fail with nonoperative management. Of the 18 @entity0 , 17 underwent surgery. One of these died: the others did well during short-term followup (less than 1 year).

title: @entity4 with @entity7 from penetrating XXXX .

answer: @entity3


abstract: UNASSIGNED: Following the mass vaccinations against pandemic @entity4 in 2009, a sudden increase in juvenile onset @entity6 with @entity7 (NC) was detected in several European countries where AS03-adjuvanted Pandemrix vaccine had been used. NC is a chronic @entity1 characterized by excessive @entity2 and @entity7 . In @entity0 NC, the hypocretin-producing neurons in the @entity5 or the hypocretin signaling pathway are destroyed by an autoimmune reaction. Both genetic (e.g. @entity8 *0602) and environmental risk factors (e.g. Pandemrix) contribute to the disease development, but the underlying and the mediating immunological mechanisms are largely unknown. Influenza virus hemagglutinin is known to bind gangliosides, which serve as host cell virus receptors. Anti- @entity9 antibodies have previously been linked to various @entity1 , like the @entity10 which may develop after @entity3 or vaccination. Because of these links we screened sera of NC @entity0 and controls for IgG anti- @entity9 antibodies against 11 @entity0 brain gangliosides (GM1, GM2, GM3, GM4, GD1a, GD1b, GD2, @entity11 , GT1a, GT1b, GQ1b) and a sulfatide by using a line blot assay. Samples from 173 @entity0 and adolescents were analyzed: 48 with Pandemrix-associated NC, 20 with NC without Pandemrix association, 57 Pandemrix-vaccinated and 48 unvaccinated healthy @entity0 . We found that @entity0 with Pandemrix-associated NC had more frequently (14.6%) anti-GM3 antibodies than vaccinated healthy controls (3.5%) (P = 0.047). Anti-GM3 antibodies were significantly associated with @entity8 *0602 (P  =  0.016) both in vaccinated NC @entity0 and controls. In general, anti- @entity9 antibodies were more frequent in vaccinated (18.1%) than in unvaccinated (7.3%) individuals (P  =  0.035). Our data suggest that autoimmunity against GM3 is a feature of Pandemrix-associated NC and that autoantibodies against gangliosides were induced by Pandemrix vaccination.

title: Autoantibodies against ganglioside GM3 are associated with XXXX developing after Pandemrix vaccination against 2009 pandemic H1N1 type influenza virus.

answer: @entity6


abstract: Genome imprinting has an essential role in normal embryonal @entity0 development. Starting early in differentiation, the transcripts of certain @entity0 genes, e.g. the paternally- @entity10 and the maternally-imprinted @entity8 , are expressed in specific tissues and organs during fetal life. In several @entity1 , imprinted genes are, again, unfolded. Characteristically, expression follows the same tissue presentation as during embryogenesis. Clinical paternal disomies, i.e. @entity6 , and their maternal counterpart, i.e. @entity2 , are associated with apparent relaxation of imprinting once they turn malignant. Paediatric @entity1 , like @entity7 ( @entity7 ) and @entity5 , often express @entity8 and @entity10 . Recently, we have found @entity10 expression in invasive @entity1 . Evidently, imprinted genes display an oncodevelopmental mode of expression, very much like the classical oncofetal proteins @entity3 and @entity4 . Based on available data, including @entity1 preferential paternal allele retention and chromosome 11 short arm physical linkage with oncogenes like @entity9 , we hypothesize that imprinted genes not only accompany @entity1 but may play a causative role as well.

title: On the oncodevelopmental role of XXXX imprinted genes.

answer: @entity0


abstract: To determine the efficacy of oral gold in @entity5 , 20 @entity0 with @entity3 -dependent @entity5 received @entity7 at a dose of 3 mg by mouth, twice daily, in a 24-week open clinical trial. Prospective evaluation of bronchial responsiveness to @entity8 was determined before and 8 and 16 weeks after initiation of @entity7 therapy. Serial spirometry (FEV1 and FVC), lung volumes, and diffusing capacities (single breath @entity6 diffusing capacity of the lungs) were measured before and at 10 and 20 weeks after treatment. All subjects were required to record concomitant medications, symptom scores, and morning and evening peak expiratory flow rates. In vitro immunologic studies performed before and after 8 and 20 weeks of @entity7 therapy included leukocyte @entity1 release in response to antihuman IgE, lymphocyte blast transformation in response to concanavalin A and phytohemagglutinin, and leukocyte inhibitory factor activity in response to @entity9 and @entity2 toxoid antigens. In 18 @entity0 evaluated, there were no significant differences between baseline and posttreatment spirometry, single breath @entity6 diffusing capacity of the lungs, and lung volumes. At week 16 of treatment, the @entity3 cumulative dose or the total @entity4 dose administered from 7 days before through 10 days after each @entity8 test day decreased from a mean of 293 +/- 125 mg at baseline to 192 +/- 115 mg. At week 16, nine of 18 @entity0 (50%) exhibited decreased @entity8 responsiveness as defined by a more than one-half log10 increase in the concentration of @entity8 causing a 20% decrease in FEV1. A significant correlation (r = 0.60) was observed between the increase in the concentration of @entity8 causing a 20% decrease in FEV1 and the decrease in @entity3 cumulative dose after 16 weeks of treatment. Leukocyte @entity1 release to anti-IgE exhibited significant reductions from baseline at week 20 to 10(-2) (p less than 0.002) and at 10(-3) (p less than 0.005) dilutions. At week 20, leukocyte inhibitory factor activity in response to Candida increased from baseline at the 0.1 mg per well (p = 0.025) and 1 mg per well (p = 0.05) concentrations; similarly, the responses to @entity2 toxoid increased at the 1 mg per well (p less than 0.05) and 0.1 mg per well (p less than 0.01) concentrations.(ABSTRACT TRUNCATED AT 400 WORDS)

title: An open study of @entity7 in the treatment of XXXX -dependent @entity5 .

answer: @entity3


abstract: To determine the efficacy of oral gold in @entity5 , 20 @entity0 with @entity3 -dependent @entity5 received @entity7 at a dose of 3 mg by mouth, twice daily, in a 24-week open clinical trial. Prospective evaluation of bronchial responsiveness to @entity8 was determined before and 8 and 16 weeks after initiation of @entity7 therapy. Serial spirometry (FEV1 and FVC), lung volumes, and diffusing capacities (single breath @entity6 diffusing capacity of the lungs) were measured before and at 10 and 20 weeks after treatment. All subjects were required to record concomitant medications, symptom scores, and morning and evening peak expiratory flow rates. In vitro immunologic studies performed before and after 8 and 20 weeks of @entity7 therapy included leukocyte @entity1 release in response to antihuman IgE, lymphocyte blast transformation in response to concanavalin A and phytohemagglutinin, and leukocyte inhibitory factor activity in response to @entity9 and @entity2 toxoid antigens. In 18 @entity0 evaluated, there were no significant differences between baseline and posttreatment spirometry, single breath @entity6 diffusing capacity of the lungs, and lung volumes. At week 16 of treatment, the @entity3 cumulative dose or the total @entity4 dose administered from 7 days before through 10 days after each @entity8 test day decreased from a mean of 293 +/- 125 mg at baseline to 192 +/- 115 mg. At week 16, nine of 18 @entity0 (50%) exhibited decreased @entity8 responsiveness as defined by a more than one-half log10 increase in the concentration of @entity8 causing a 20% decrease in FEV1. A significant correlation (r = 0.60) was observed between the increase in the concentration of @entity8 causing a 20% decrease in FEV1 and the decrease in @entity3 cumulative dose after 16 weeks of treatment. Leukocyte @entity1 release to anti-IgE exhibited significant reductions from baseline at week 20 to 10(-2) (p less than 0.002) and at 10(-3) (p less than 0.005) dilutions. At week 20, leukocyte inhibitory factor activity in response to Candida increased from baseline at the 0.1 mg per well (p = 0.025) and 1 mg per well (p = 0.05) concentrations; similarly, the responses to @entity2 toxoid increased at the 1 mg per well (p less than 0.05) and 0.1 mg per well (p less than 0.01) concentrations.(ABSTRACT TRUNCATED AT 400 WORDS)

title: An open study of XXXX in the treatment of @entity3 -dependent @entity5 .

answer: @entity7


abstract: To determine the efficacy of oral gold in @entity5 , 20 @entity0 with @entity3 -dependent @entity5 received @entity7 at a dose of 3 mg by mouth, twice daily, in a 24-week open clinical trial. Prospective evaluation of bronchial responsiveness to @entity8 was determined before and 8 and 16 weeks after initiation of @entity7 therapy. Serial spirometry (FEV1 and FVC), lung volumes, and diffusing capacities (single breath @entity6 diffusing capacity of the lungs) were measured before and at 10 and 20 weeks after treatment. All subjects were required to record concomitant medications, symptom scores, and morning and evening peak expiratory flow rates. In vitro immunologic studies performed before and after 8 and 20 weeks of @entity7 therapy included leukocyte @entity1 release in response to antihuman IgE, lymphocyte blast transformation in response to concanavalin A and phytohemagglutinin, and leukocyte inhibitory factor activity in response to @entity9 and @entity2 toxoid antigens. In 18 @entity0 evaluated, there were no significant differences between baseline and posttreatment spirometry, single breath @entity6 diffusing capacity of the lungs, and lung volumes. At week 16 of treatment, the @entity3 cumulative dose or the total @entity4 dose administered from 7 days before through 10 days after each @entity8 test day decreased from a mean of 293 +/- 125 mg at baseline to 192 +/- 115 mg. At week 16, nine of 18 @entity0 (50%) exhibited decreased @entity8 responsiveness as defined by a more than one-half log10 increase in the concentration of @entity8 causing a 20% decrease in FEV1. A significant correlation (r = 0.60) was observed between the increase in the concentration of @entity8 causing a 20% decrease in FEV1 and the decrease in @entity3 cumulative dose after 16 weeks of treatment. Leukocyte @entity1 release to anti-IgE exhibited significant reductions from baseline at week 20 to 10(-2) (p less than 0.002) and at 10(-3) (p less than 0.005) dilutions. At week 20, leukocyte inhibitory factor activity in response to Candida increased from baseline at the 0.1 mg per well (p = 0.025) and 1 mg per well (p = 0.05) concentrations; similarly, the responses to @entity2 toxoid increased at the 1 mg per well (p less than 0.05) and 0.1 mg per well (p less than 0.01) concentrations.(ABSTRACT TRUNCATED AT 400 WORDS)

title: An open study of @entity7 in the treatment of @entity3 -dependent XXXX .

answer: @entity5


abstract: OBJECTIVE: Little is known about the evolution and long-term neurological status of pediatric @entity0 who survive out-of-hospital @entity2 . Our aim is to describe long-term survival and neurological status. DESIGN: Retrospective observational study, based on the Andalusian Register of out-of-hospital Cardiac Arrest. SETTING: Pre-hospital Care. @entity0 : The study included @entity0 aged 0-15 years between January 2008 and December 2012. INTERVENTIONS: @entity0 follow up. VARIABLES: Prehospital and hospital care variables were analyzed and one-year follow-up was performed, along with a specific follow-up of survivors in June 2014. RESULTS: Of 5069 @entity0 included in the register, 125 (2.5%) were aged  <=15 years. @entity2 was witnessed in 52.8% of cases and resuscitation was performed in 65.6%. The initial rhythm was shockable in 7 (5.2%) cases. Nearly half (48.8%) the @entity0 reached the hospital alive, of whom 20% did so while receiving resuscitation maneuvers. Only 9 (7.2%) @entity0 survived to hospital discharge; 5 showed ad integrum recovery and 4 showed significant @entity1 . The 5 @entity0 with complete recovery continued their long-term situation. The remaining 4 @entity0 , although slight improvement, were maintained in situation of @entity1 . CONCLUSIONS: Survival after out-of-hospital @entity2 in pediatric @entity0 was low. The long-term prognosis of survivors with good neurological recovery remains, although improvement in the rest was minimal.

title: Survival and neurological status after out-of-hospital XXXX in the pediatric population in Andalusia.

answer: @entity2


abstract: To learn how the outcomes of emergency room (ER) care relate to the decision-making process, criteria for the disposition of @entity1 in the ER were incorporated into a formal protocol in the form of an algorithm for use by pediatric resident physicians. We compared the application of those criteria with the consequences of 199 decisions to admit @entity0 to the hospital for @entity1 and of 293 decisions to discharge @entity0 from the ER. For most @entity0 the chance of relapse was significantly raised if they were discharged from the ER when the protocol had specified admission. This was not true, however, for a group of "frequent visitors" (12.7% of all @entity0 ) who accounted for 66.3% of all relapses. This finding offers an explanation for previous difficulties in identifying characteristics of visits destined to be followed by relapse. @entity0 were placed in jeopardy by inappropriate ER discharges only if they were high-risk @entity0 who had experienced prior episodes of @entity2 . Nearly all admissions involving severe episodes of @entity1 were also limited to high-risk @entity0 . A variety of criteria supported such admissions. At the other extreme, "avoidable" admissions, in which obstruction resolved within a few hours of admission, occurred equally among all @entity0 strata, and no particular admission criterion could be held at fault for admission of such rapidly remitting cases. The results support the use of explicit, quantitative criteria for guiding ER disposition of @entity1 , especially specific arrangements for management of ER visits by high-risk @entity0 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Outcomes of emergency room visits for XXXX . II. Relationship to admission criteria.

answer: @entity1


abstract: Between January 1980 and September 1985, 35 adult @entity0 with resectable retroperitoneal soft tissue @entity1 were entered on a randomized trial comparing two forms of adjuvant radiation therapy. Fifteen @entity0 received the experimental therapy consisting of intraoperative radiotherapy (IORT) to 20 Gy using high-energy electrons followed by low-dose (35 to 40 Gy) postoperative external beam irradiation. Twenty @entity0 received standard therapy consisting of high-dose (50 to 55 Gy) postoperative external beam irradiation. With a minimum follow-up of 15 months, there is no significant difference in the actuarial disease-free survival (DFS) and overall survival (OS) comparing the two groups (median DFS, 34 months; median OS, 38 months). At 5 years follow-up, approximately 40% of @entity0 are alive and 20% of @entity0 remain disease-free. Although there is a trend towards an improvement in in-field local control in the experimental arm, the predominant pattern of failure in both groups was locoregional within the retroperitoneum and/or peritoneal cavity. Acute and late @entity2 were significantly reduced in the experimental group. However, four experimental @entity0 developed late (greater than 6 months following treatment) @entity3 believed related to the use of IORT; all four recovered. We conclude that there is no difference in the therapeutic effectiveness of the combination of IORT and low-dose external beam radiation compared with conventional high-dose radiation as adjuvant treatment in @entity1 , although the former appears to be less toxic. Newer combined modality treatment strategies are discussed to improve the prognosis in these @entity0 .

title: Preliminary results of a randomized study of adjuvant radiation therapy in resectable adult retroperitoneal soft tissue XXXX .

answer: @entity1


abstract: Growth at the anastomotic site after continuous vascular @entity1 in the pediatric @entity0 remains a problem. Primary end-to-end @entity1 of the infrarenal aorta was performed with absorbable Maxon suture or nonabsorbable @entity6 suture in 20 piglets. Ten of the Maxon suture group and nine of the @entity6 suture group survived; one @entity5 died of @entity2 . The animals were put to death 6 months after the operation. Each abdominal aorta was removed and a roentgenogram was obtained. The aorta was then burst-tested to 300 mm Hg, measured, and examined both grossly and histologically. All anastomoses were patent and no burst failures were observed in either group. However, @entity6 sutures protruded into lumen and were partially embedded in the aortic wall in all animals in the @entity6 suture group. @entity3 adhered to the intraluminal @entity6 suture in six of nine animals. The growth of the anastomotic area was wider in the Maxon suture group (446.4% +/- 131.8% versus 317.6% +/- 121.5%, p less than 0.05). @entity4 was more common in the @entity6 suture group (7/9) than in the Maxon suture group (1/10) (p less than 0.01), but the distal segment was widely patent in both groups. Dilatation at the anastomotic site was present in eight of 10 @entity5 in the Maxon suture group and in two of nine in the @entity6 suture group. Histologic study showed that the area of tissue reaction was more prominent in the @entity6 suture group. No sutures were observed in the Maxon suture group. We therefore recommend the use of absorbable Maxon sutures for anastomoses in which the suture line must be able to grow.

title: Growth of the aortic XXXX in @entity5 . Comparison of continuous absorbable suture with nonabsorbable suture.

answer: @entity1


abstract: Growth at the anastomotic site after continuous vascular @entity1 in the pediatric @entity0 remains a problem. Primary end-to-end @entity1 of the infrarenal aorta was performed with absorbable Maxon suture or nonabsorbable @entity6 suture in 20 piglets. Ten of the Maxon suture group and nine of the @entity6 suture group survived; one @entity5 died of @entity2 . The animals were put to death 6 months after the operation. Each abdominal aorta was removed and a roentgenogram was obtained. The aorta was then burst-tested to 300 mm Hg, measured, and examined both grossly and histologically. All anastomoses were patent and no burst failures were observed in either group. However, @entity6 sutures protruded into lumen and were partially embedded in the aortic wall in all animals in the @entity6 suture group. @entity3 adhered to the intraluminal @entity6 suture in six of nine animals. The growth of the anastomotic area was wider in the Maxon suture group (446.4% +/- 131.8% versus 317.6% +/- 121.5%, p less than 0.05). @entity4 was more common in the @entity6 suture group (7/9) than in the Maxon suture group (1/10) (p less than 0.01), but the distal segment was widely patent in both groups. Dilatation at the anastomotic site was present in eight of 10 @entity5 in the Maxon suture group and in two of nine in the @entity6 suture group. Histologic study showed that the area of tissue reaction was more prominent in the @entity6 suture group. No sutures were observed in the Maxon suture group. We therefore recommend the use of absorbable Maxon sutures for anastomoses in which the suture line must be able to grow.

title: Growth of the aortic @entity1 in XXXX . Comparison of continuous absorbable suture with nonabsorbable suture.

answer: @entity5


abstract: 50 @entity1 with @entity0 were treated with an intensified regimen which consisted of high-dose @entity4 (110 mg/m2) every 2 weeks and filgrastim (5 micrograms/kg) subcutaneously for 13 days, starting 24 h after chemotherapy. 44 @entity1 completed all six cycles. The median interval between cycles of treatment was 14.3 days. The actually administered median dose per unit time per @entity1 was 53 mg/m2/week, amounting to 97.2% of the dose prescribed by the protocol. 7 [14%, 95% confidence interval (C.I.) 4-24%] @entity1 achieved a complete and 25 (50%, 95% C.I. 36-64%) a partial response. Median time to progression was 32 weeks and median survival 64 weeks. @entity6 and @entity3 each occurred in 7 (14%) @entity1 . Grade 3 haematological @entity2 was observed in 6 (12%) @entity1 . 1 (2%) @entity1 developed grade 4 @entity5 . This intensified regimen appears to be a well tolerated and effective treatment in @entity0 .

title: Intensive chemotherapy with high-dose epirubicin every 2 weeks and prophylactic administration of filgrastim in XXXX .

answer: @entity0


abstract: BACKGROUND: This article reported the experience of endovascular treatment in @entity2 with parent @entity1 or stent-assisted coiling. MATERIAL AND METHODS: Eleven consecutive @entity0 with @entity2 were included. The @entity3 predominantly involved the M1 segment in two cases, bifurcation in four cases, and M2 in five cases. Four @entity3 were treated with parent artery sacrifice after balloon occlusion test. The seven unruptured @entity3 and one ruptured one were treated with stent-assisted coiling. The post-operation and long-term follow-up angiographic and clinical outcomes were analyzed. RESULTS: Endovascular coiling was performed successfully in all 11 cases. All four M2 fusiform cases using parent @entity1 strategy achieved complete occlusion of @entity3 . In the seven cases with stent-assisted coiling, four were completely occluded, two were partially occluded and one remained small residue. Mild perioperative complications occurred in six @entity0 . The follow-up angiography taken at a mean of 13.5 months of eight @entity0 showed that seven @entity3 remained stable or improved and one M1 @entity3 relapsed and needed further treatment. CONCLUSION: Stent-assisted coiling or parent @entity1 of selected @entity2 is an option to consider.

title: Endovascular management of XXXX .

answer: @entity2


abstract: The effect of cervical group B streptococcus on the conservative management of preterm premature @entity3 was examined in 140 consecutive @entity0 . Upon the @entity0 's admission, we obtained cervical cultures for group B streptococcus, @entity4 , and @entity6 . @entity0 with and without group B streptococcus were compared. Group B streptococcus @entity0 had earlier @entity3 (30.7 versus 31.6 weeks) and shorter latent periods (76.8 versus 138.5 hours). @entity2 (six of 16 versus 26 of 120) and @entity8 (four of ten versus three of 94) were significantly more common in group B streptococcus @entity0 . Neonates of mothers positive for group B streptococcus were smaller (1749 +/- 844 versus 2100 +/- 779 g) and more likely to have @entity1 (eight of 16 versus 29 of 120; P less than .01). Control for the presence of @entity9 , @entity6 , listeria, or @entity7 failed to change the significance of these results. The usual policy was to use intrapartum ampicillin prophylaxis in asymptomatic group B streptococcus @entity0 . However, only four of 16 remained asymptomatic and had latent periods long enough for the results of cultures obtained on admission to be available. We conclude that group B streptococcus significantly complicates the conservative management of preterm premature @entity3 and that the effectiveness of intrapartum prophylactic @entity5 may be compromised by awaiting the results of conventional cultures to define colonized @entity0 .

title: Group B streptococcus and preterm XXXX .

answer: @entity3


abstract: Morphometric analysis of the follicle population greater than or equal to 100 X 10(5) micron 3 or a mean diameter of greater than or equal to 275 micron and assessment of the rate of @entity1 in ovaries of pregnant and pseudopregnant @entity0 revealed no evidence for the presence of rhythmic follicular maturation during the prolonged dioestrous period. During the first 4-5 days of the dioestrous period, follicles developed to preovulatory size (volume class 5, i.e. greater than or equal to 1000 X 10(5) micron 3 = diam. greater than or equal to 576 micron) reaching the normal number of ovulating follicles in cyclic animals in pregnant @entity0 , but only half that number in pseudopregnant @entity0 . These follicles collapsed on the 5th to 8th days of the dioestrous period and full numbers of preovulatory follicles were not found thereafter until the end of pregnancy and pseudopregnancy. Follicles of smaller sizes (classes 1-4: 100-999 X 10(5) micron 3), however, were present throughout the prolonged dioestrous period. The rate of @entity1 in the follicle population had increased by the 2nd day and remained from then on at 26.5 +/- 4.5% in the pregnant and 34.3 +/- 1.9% in the pseudopregnant @entity0 . Atretic follicles in the advanced stages of @entity1 , mostly derived from follicles of classes 1-3, persisted and accumulated at the end of the dioestrous period. The continuous presence of follicles and the constant rate of @entity1 during the dioestrous period indicate continuous follicular replacements and refute the idea of follicular quiescence during pregnancy and pseudopregnancy. Copulation and electrical stimulation of the cervix seemed to reduce the formation of the new crop of follicles the next morning and the pool of small antral follicles normally maintained after oestrus in cyclic animals. Nevertheless, the smaller crop and pool of follicles seemed able to provide a sufficient number of preovulatory follicles at the end of pregnancy and a sufficient number of ovulations at the end of pseudopregnancy.

title: Morphometric analysis of follicular dynamics in pregnant and pseudopregnant XXXX .

answer: @entity0


abstract: The effects of the recently identified @entity6 / @entity7 (FL) on the growth of purified @entity0 fetal liver progenitors were investigated under serum-deprived culture conditions. FL alone was found to stimulate modest proliferation in short-term cultures of @entity1 ++ @entity4 + lineage (Lin)- light-density fetal liver (LDFL) cells and the more primitive @entity1 ++ @entity4 - Lin- LDFL cells. However, the low levels of growth induced by FL were insufficient for colony formation in clonal cultures. Synergism between FL and either @entity3 ( @entity3 ), @entity2 ( @entity2 ) or @entity5 (KL) was observed in promoting the growth of high-proliferative potential (HPP) colony-forming cells (CF) and/or low-proliferative potential (LPP)-CFC in cultures of @entity1 ++ @entity4 + @entity8 - and @entity1 ++ @entity4 - Lin- LDFL-cells. FL, alone or in combination with other cytokines, was not found to affect the growth of @entity1 + Lin- LDFL cells, the most mature subpopulation of fetal liver progenitors investigated. The growth of the most primitive subset of progenitors studied, @entity1 ++ @entity4 - Lin- LDFL cells, required the interactions of at least two cytokines, because only very low levels of growth were observed in response to either FL, @entity3 , @entity2 or KL alone. However, the results of delayed cytokine-addition experiments suggested that individually these cytokines did promote the survival of this early population of progenitors. Although two-factor combinations of FL, KL, and @entity3 were observed to promote the growth of early progenitors in a synergistic manner, neither of these factors was found to make fetal liver progenitors more responsive to suboptimal concentrations of a second cytokine. Only myeloid cells were recovered from liquid cultures of @entity1 ++ @entity4 - Lin- LDFL cells grown in the presence of combinations of FL, KL, and @entity3 . These results indicate that FL is part of a network of growth factors that regulate the growth and survival of early hematopoietic progenitors.

title: FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from XXXX fetal liver.

answer: @entity0


abstract: @entity5 occurs more than twice as frequently as @entity1 . The main risk factors are age, @entity3 use, and @entity2 . Increasing life expectancy and more liberal use of @entity3 to prevent @entity9 will probably increase the magnitude of the problem. @entity5 is a heterogeneous disease. Good prognosis is associated with @entity2 and @entity3 use and with @entity4 preceded by @entity6 . A bad prognosis may be found in @entity0 without major risk factors and is associated with a normal or @entity7 endometrium. Because of a high prevalence of @entity8 (6.9 per 1,000) and because the group with a poor prognosis is usually asymptomatic, all postmenopausal @entity0 should be screened at least one time. For screening, the use of one of the cytologic instruments is recommended; these instruments are safe, easy to handle, and can be used in the office setting without anesthesia. Yields are comparable to dilation and curettage. Family physicians are encouraged to familiarize themselves with cytologic instruments and to use them for screening postmenopausal @entity0 in their office.

title: Detection of and screening for XXXX .

answer: @entity5


abstract: The prognostic value of cellular DNA content in @entity2 ( @entity3 ) was investigated by flow cytometric analysis of paraffin-embedded @entity1 blocks from 128 previously untreated @entity0 with International Federation of Gynecology and Obstetrics (FIGO) stage III and IV @entity2 entered in a prospective clinical trial of combination v sequential therapy with @entity6 and @entity4 . Seventy-three percent of @entity1 were @entity5 and 27% were diploid. Multivariate analysis using a Cox model showed that cellular DNA content (P less than .001) and FIGO stage (P less than .02) were the only significant independent prognostic variables. The median survival was 13 months for @entity0 with @entity1 and 60 months for @entity0 with @entity1 (P less than .0001). Further analysis indicated that the good prognosis associated with @entity1 was limited to @entity0 with @entity1 , all @entity0 with stage IV (spread beyond the peritoneal cavity or liver metastases) disease having a poor prognosis irrespective of ploidy. On pathological review, nine borderline @entity2 (of low malignant potential) were identified, and seven of these were diploid. These @entity1 have an unusually favorable prognosis, despite apparent dissemination within the peritoneal cavity, a paradox which is often difficult to explain using conventional histological criteria. Although the vast majority of @entity1 in this study (93%) were classified as @entity2 , it is possible that some of the @entity0 with @entity1 may have had @entity1 that were predominantly of low malignant potential, thus accounting in part for the prognostic significance of DNA content. By incorporating flow cytometric DNA analysis with careful histopathological assessment, it may be possible to better identify @entity0 with an inherently good prognosis. This assumes particular importance, as the relatively favorable prognosis of @entity0 with @entity2 appears to be independent of the type of treatment.

title: Prediction of long-term survival by flow cytometric analysis of cellular DNA content in @entity0 with advanced XXXX .

answer: @entity2


abstract: The prognostic value of cellular DNA content in @entity2 ( @entity3 ) was investigated by flow cytometric analysis of paraffin-embedded @entity1 blocks from 128 previously untreated @entity0 with International Federation of Gynecology and Obstetrics (FIGO) stage III and IV @entity2 entered in a prospective clinical trial of combination v sequential therapy with @entity6 and @entity4 . Seventy-three percent of @entity1 were @entity5 and 27% were diploid. Multivariate analysis using a Cox model showed that cellular DNA content (P less than .001) and FIGO stage (P less than .02) were the only significant independent prognostic variables. The median survival was 13 months for @entity0 with @entity1 and 60 months for @entity0 with @entity1 (P less than .0001). Further analysis indicated that the good prognosis associated with @entity1 was limited to @entity0 with @entity1 , all @entity0 with stage IV (spread beyond the peritoneal cavity or liver metastases) disease having a poor prognosis irrespective of ploidy. On pathological review, nine borderline @entity2 (of low malignant potential) were identified, and seven of these were diploid. These @entity1 have an unusually favorable prognosis, despite apparent dissemination within the peritoneal cavity, a paradox which is often difficult to explain using conventional histological criteria. Although the vast majority of @entity1 in this study (93%) were classified as @entity2 , it is possible that some of the @entity0 with @entity1 may have had @entity1 that were predominantly of low malignant potential, thus accounting in part for the prognostic significance of DNA content. By incorporating flow cytometric DNA analysis with careful histopathological assessment, it may be possible to better identify @entity0 with an inherently good prognosis. This assumes particular importance, as the relatively favorable prognosis of @entity0 with @entity2 appears to be independent of the type of treatment.

title: Prediction of long-term survival by flow cytometric analysis of cellular DNA content in XXXX with advanced @entity2 .

answer: @entity0


abstract: The purpose of this study was to examine the role of angiotensin II (ANG II), @entity4 ( @entity1 ), and neurogenic mechanisms in maintaining arterial pressure (MAP) in conscious water-deprived @entity0 . @entity2 produced marked increases in plasma @entity5 activity and the concentration of AVP; however, plasma @entity3 concentrations were unchanged. Arterial baroreflex control of renal sympathetic nerve activity (RSNA) and heart rate (HR) was similar in water-replete and dehydrated animals. Administration of an ANG II receptor antagonist (ANG IIX) to water-deprived animals produced a small decrease in MAP but no significant changes in HR or mesenteric and hindquarters vascular resistances. Similarly, there was no significant effect on MAP, HR, or regional hemodynamics when dehydrated animals received an AVP-V1 antagonist (AVPX). RSNA increased by maximums of 61 and 43% in response to ANG IIX and AVPX, respectively. Combined administration of ANG IIX and AVPX produced significant decreases in MAP (-9 mmHg) and hindquarters resistance (-24%) and 117% and 23 beat/min increases in RSNA and HR, respectively. The effect on mesenteric resistance was variable; however, the response was generally a decrease. We conclude that ANG II and AVP pressor mechanisms are activated to sustain MAP in the dehydrated state. In contrast, the basal level and baroreflex control of sympathetic nervous system activity are unchanged from the water-replete state. However, activation of sympathetic nerve activity may become important in maintaining peripheral resistance when ANG II and AVP receptors are blocked in water-deprived animals.

title: Neurohumoral interactions in conscious dehydrated XXXX .

answer: @entity0


abstract: The @entity0 Reported Outcomes Measurement Information System (PROMIS) was devised to facilitate assessment of @entity0 self-reported health status, taking advantage of Item Response Theory. We aimed to assess measurement properties of the PROMIS @entity2 item bank and an 8-item static short form in a Spanish clinical sample. A three-month follow-up study of @entity0 with active mood/ @entity1 symptoms (n = 218) was carried out. We assessed model unidimensionality (Confirmatory Item Factor Analysis), reliability (internal consistency and Item Information Curves), and validity (convergent-discriminant with correlations; known-groups with comparison of means and effect sizes; and criterion validity with Receiver operating Characteristics (ROC) analysis). We also assessed 3-month responsiveness to change (Cohen's effect sizes (d) in stable and recovered @entity0 ). The unidimensional model showed adequate fit (CFI = 0.97, RMSEA = 0.08). Information Curves had reliabilities over 0.90 throughout most of the score continuum. As expected, we observed high correlations with external self-reported @entity2 , and moderate with self-reported @entity1 and clinical measures. The item bank showed an increasing severity gradient from no disorder (mean = 48, SE = 0.6) to @entity2 with comorbid @entity1 (mean = 55.8, SE = 0.4). PROMIS detected @entity2 with great accuracy according to the area under the curve (AUC = 0.89). Both formats, item bank and short form, were highly responsive to change in recovered @entity0 (d > 0.7) and had small changes in stable @entity0 (d < 0.2). The good metric properties of the Spanish PROMIS @entity2 measures provide further evidence of their adequacy for monitoring @entity2 levels of @entity0 in clinical settings. This double check of quality (within countries and populations) supports the ability of PROMIS measures for guaranteeing fair comparisons across languages and countries in specific clinical populations.

title: Testing the PROMIS   XXXX measures for monitoring @entity2 in a clinical sample outside the US.

answer: @entity2


abstract: The @entity0 Reported Outcomes Measurement Information System (PROMIS) was devised to facilitate assessment of @entity0 self-reported health status, taking advantage of Item Response Theory. We aimed to assess measurement properties of the PROMIS @entity2 item bank and an 8-item static short form in a Spanish clinical sample. A three-month follow-up study of @entity0 with active mood/ @entity1 symptoms (n = 218) was carried out. We assessed model unidimensionality (Confirmatory Item Factor Analysis), reliability (internal consistency and Item Information Curves), and validity (convergent-discriminant with correlations; known-groups with comparison of means and effect sizes; and criterion validity with Receiver operating Characteristics (ROC) analysis). We also assessed 3-month responsiveness to change (Cohen's effect sizes (d) in stable and recovered @entity0 ). The unidimensional model showed adequate fit (CFI = 0.97, RMSEA = 0.08). Information Curves had reliabilities over 0.90 throughout most of the score continuum. As expected, we observed high correlations with external self-reported @entity2 , and moderate with self-reported @entity1 and clinical measures. The item bank showed an increasing severity gradient from no disorder (mean = 48, SE = 0.6) to @entity2 with comorbid @entity1 (mean = 55.8, SE = 0.4). PROMIS detected @entity2 with great accuracy according to the area under the curve (AUC = 0.89). Both formats, item bank and short form, were highly responsive to change in recovered @entity0 (d > 0.7) and had small changes in stable @entity0 (d < 0.2). The good metric properties of the Spanish PROMIS @entity2 measures provide further evidence of their adequacy for monitoring @entity2 levels of @entity0 in clinical settings. This double check of quality (within countries and populations) supports the ability of PROMIS measures for guaranteeing fair comparisons across languages and countries in specific clinical populations.

title: Testing the PROMIS   @entity2 measures for monitoring XXXX in a clinical sample outside the US.

answer: @entity2


abstract: In mammals and insects, paracellular blood barriers isolate the nervous system from the rest of the animal. Glia and accessory cells of the nervous system use pumps, channels, cotransporters, and exchangers collectively to maintain the extracellular ion environment and osmotic balance in the nervous system. At present, the molecular mechanisms that regulate this process remain unclear. In @entity0 , loss of extracellular ion and volume regulation in the nervous system poses serious health threats. @entity1 is a model genetic organism with a proven track record for uncovering molecular mechanisms relevant to @entity0 health and disease. Here, we review what is known about extracellular ion and volume regulation in larval abdominal nerves, present some new data about the impact of neural activity on the extracellular environment, and relate the findings to @entity0 systems. Homologies have been found at the level of morphology, physiology, molecular mechanisms, and mutant phenotypes. The Fray-Ncc69 module regulates extracellular volume in larval nerves. Genetic rescue experiments with the @entity0 orthologs prove this module has a direct correlate in @entity0 . This and other molecular homologies, together with the similar physiological needs, suggest that uncovering the molecular mechanisms of ion and volume regulation in larval nerves will likely provide significant insights into this process in @entity0 systems.

title: Maintenance and regulation of extracellular volume and the ion environment in XXXX larval nerves.

answer: @entity1


abstract: Microglial cells invade the central nervous system during embryonic development, but their developmental functional roles in vivo remain largely unknown. Accordingly, their invasion pattern during early embryonic development is still poorly understood. To address this issue, we analyzed the initial developmental pattern of microglial cell invasion in the spinal cord of @entity3 -eGFP @entity0 embryos using immunohistochemistry. Microglial cells began to invade the @entity0 embryonic spinal cord at a developmental period corresponding to the onset of spontaneous electrical activity and of synaptogenesis. Microglial cells reached the spinal cord through the peripheral vasculature and began to invade the parenchyma at 11.5 days of embryonic age (E11.5). Remarkably, at E12.5, activated microglial cells aggregated in the dorsolateral region close to terminals of dying dorsal root ganglia neurons. At E13.5, microglial cells in the ventral marginal zone interacted with radial glial cells, whereas ramified microglial cells within the parenchyma interacted with growing capillaries. At this age, activated microglial cells ( @entity2 staining) also accumulated within the lateral motor columns at the onset of the developmental cell death of motoneurons. This cell aggregation was still observed at E14.5, but microglial cells no longer expressed @entity2 . At E15.5, microglial cells were randomly distributed within the parenchyma. Our results provide the essential basis for further studies on the role of microglial cells in the early development of @entity1 in vivo.

title: Pattern of invasion of the embryonic XXXX spinal cord by microglial cells at the time of the onset of functional neuronal networks.

answer: @entity0


abstract: OBJECTIVES: To describe the clinical history and ultrasound findings in @entity0 with @entity2 . METHODS: This was a retrospective study of @entity0 with a histological diagnosis of @entity2 who had undergone preoperative ultrasound examination. The @entity0 were identified from the databases of 11 ultrasound centers. The @entity1 were described by the principal investigator at each contributing center on the basis of ultrasound images, ultrasound reports and research protocols (when applicable) using the terms and definitions of the International @entity2 Analysis (IOTA) group. In addition, three authors reviewed all available electronic ultrasound images (gray-scale images and color/power Doppler images were available for 18 @entity0 and 14 @entity0 , respectively) and described them using subjective evaluation of gray-scale and color Doppler ultrasound findings (here called pattern recognition). RESULTS: Twenty-one @entity0 with @entity2 were identified (including one @entity0 with bilateral masses). Twenty @entity0 had a primary @entity2 (including the one with bilateral masses) and one @entity0 had a recurrence of @entity9 in her retained ovary. One of the 21 @entity0 was pregnant. All @entity1 except one were @entity9 , one being a mixed @entity1 with 30% @entity9 component. Median age was 20 (range, 16-31) years. Information on clinical symptoms was available for 18 @entity0 . In four @entity0 , the @entity1 was detected incidentally, whereas 14 @entity0 presented with one or more of the following symptoms: acute @entity3 (n = 4), @entity6 (n = 8), bloating (n = 8), @entity7 (n = 5) and @entity4 problems (n = 1). One (5%) @entity0 had @entity5 . Using the IOTA terms and definitions, all but one @entity9 were moderately (43%) or very well (50%) vascularized solid @entity1 . One @entity1 was multilocular-solid. According to pattern recognition, most @entity9 were highly vascularized, purely solid @entity1 with heterogeneous internal echogenicity divided into several lobules, had a smooth and sometimes lobulated contour and were well-defined relative to the surrounding organs. CONCLUSION: The ultrasound finding of a highly vascularized, large, solid, lobulated @entity8 with irregular internal echogenicity in a @entity0 20-30 years old should raise the suspicion of @entity2 .

title: Imaging of gynecological disease (6): clinical and ultrasound characteristics of XXXX .

answer: @entity2


abstract: The effect of M-VAC ( @entity5 , @entity6 , @entity3 and @entity4 ) chemotherapy supported recombinant @entity0 granulocyte stimulating factor ( @entity7 ) was studied in 18 @entity0 with metastatic @entity2 . The mean age of the @entity0 was 66 years. Of the @entity0 6 had lung @entity1 and 12 had distant lymph node @entity1 . In this study recombinant @entity0 granulocyte stimulating factor was administered therapeutically at 100 to 250 micrograms subcutaneously after the white blood cell count was less than 3,000/mm. Relative dose-intensity (RDI) was 0.88 +/- 0.11 and 0.72 +/- 0.19 for 11 @entity0 with @entity7 and 7 without @entity7 , respectively. The relative dose regardless of the interval of the cycle of M-VAC chemotherapy (%Dose) was 0.95 +/- 0.06 and 0.86 +/- 0.09 for the @entity0 with @entity7 and those without @entity7 , respectively. Of seven @entity0 without @entity7 3 @entity0 responded (response rate 42%, mean survival period 7.4 months). Of 11 @entity0 treated with @entity7 3 @entity0 responded (response rate 72.7%, mean survival period 20.0 months). Although @entity7 increased the RDI of M-VAC chemotherapy, the correlation of response with RDI was not clearly demonstrated. The therapeutical administrations of @entity7 fail to improve the mean white blood cell nadir and to prevent the decrease of the platelet and reticulocyte count.

title: [Dose intensity in M-VAC chemotherapy with XXXX for metastatic transitional urothelial cancer].

answer: @entity7


abstract: @entity1 maternal behavior is a complex social behavior. Many clinically used antipsychotic drugs, including the typical drug @entity8 and the atypical drugs @entity5 , @entity7 , @entity4 , @entity6 , @entity9 , and @entity10 , disrupt active maternal responses (e.g. pup retrieval, pup licking, and nest building) to various extents. In this review, I present a summary of recent studies on the behavioral effects and neurobiological mechanisms of antipsychotic action on maternal behavior in @entity1 . I argue that antipsychotic drugs at clinically relevant doses disrupt active maternal responses primarily by suppressing maternal motivation. Atypical drug-induced sedation also contributes to their disruptive effects, especially that on pup nursing. Among many potential receptor mechanisms, @entity3 D2 receptors and @entity2 5-HT2A/2C receptors are shown to be critically involved in the mediation of the maternal disruptive effects of antipsychotic drugs, with D2 receptors contributing more to typical antipsychotic-induced disruptions, whereas 5-HT2A/2C receptors contributing more to atypical drug-induced disruptions. The nucleus accumbens shell-related reward circuitry is an essential neural network in the mediation of the behavioral effects of antipsychotic drugs on maternal behavior. This research not only helps understand the extent and mechanisms of impact of antipsychotic medications on @entity0 maternal care, but is also important for enhancing our understanding of the neurochemical basis of maternal behavior. It is also valuable for understanding the complete spectrum of therapeutic effects and side-effects of antipsychotic treatment. This knowledge may facilitate the development of effective intervening strategies to help @entity0 coping with such undesirable effects.

title: Antipsychotic drugs on maternal behavior in XXXX .

answer: @entity1


abstract: Two synthetic peptides, P354-14 ( @entity1 nos. 354 to 367) and P338-16 (nos. 338 to 353), corresponding to the partial @entity1 sequences of the hTSH receptor structure were studied for their ability to bind specifically serum IgGs from @entity0 with @entity3 and to inhibit thyroid stimulating TSH receptor antibody ( @entity4 SAb) activity. IgG binding was measured by an ELISA using sera from 102 Graves', 20 @entity2 @entity0 , and 9 normal subjects. Both peptides showed significantly increased IgG binding of Graves' sera compared with those of @entity2 and normal sera. There was a significant correlation (r = 0.529) between the amount of IgG bound by the two peptides, but neither of these values correlated well with their @entity4 SAb activity nor thyrotropin-binding inhibitor TSH receptor antibody ( @entity4 IAb) activity. @entity4 SAb inhibiting effects of these peptides were then analysed by measuring @entity4 SAb activity after incubation with the peptides. Among eight Graves' IgGs tested the @entity4 SAb activity of three was inhibited by both peptides, two were inhibited only by P354-14 and three were not affected by either. These @entity4 SAb inhibiting effects were dose-dependent and reproducible. To confirm these findings, a peptide-sepharose gel affinity absorption study was performed. Eleven Graves' IgGs were applied to both peptide gels and the @entity4 SAb activity of the unabsorbed fraction was measured. The @entity4 SAb activity of five IgGs was strongly absorbed only by P354-14 and five others were absorbed by both peptides to an almost similar extent.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Thyroid-stimulating antibodies in sera from @entity0 with XXXX are heterogeneous in epitope recognition.

answer: @entity3


abstract: Two synthetic peptides, P354-14 ( @entity1 nos. 354 to 367) and P338-16 (nos. 338 to 353), corresponding to the partial @entity1 sequences of the hTSH receptor structure were studied for their ability to bind specifically serum IgGs from @entity0 with @entity3 and to inhibit thyroid stimulating TSH receptor antibody ( @entity4 SAb) activity. IgG binding was measured by an ELISA using sera from 102 Graves', 20 @entity2 @entity0 , and 9 normal subjects. Both peptides showed significantly increased IgG binding of Graves' sera compared with those of @entity2 and normal sera. There was a significant correlation (r = 0.529) between the amount of IgG bound by the two peptides, but neither of these values correlated well with their @entity4 SAb activity nor thyrotropin-binding inhibitor TSH receptor antibody ( @entity4 IAb) activity. @entity4 SAb inhibiting effects of these peptides were then analysed by measuring @entity4 SAb activity after incubation with the peptides. Among eight Graves' IgGs tested the @entity4 SAb activity of three was inhibited by both peptides, two were inhibited only by P354-14 and three were not affected by either. These @entity4 SAb inhibiting effects were dose-dependent and reproducible. To confirm these findings, a peptide-sepharose gel affinity absorption study was performed. Eleven Graves' IgGs were applied to both peptide gels and the @entity4 SAb activity of the unabsorbed fraction was measured. The @entity4 SAb activity of five IgGs was strongly absorbed only by P354-14 and five others were absorbed by both peptides to an almost similar extent.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Thyroid-stimulating antibodies in sera from XXXX with @entity3 are heterogeneous in epitope recognition.

answer: @entity0


abstract: Diesel engine-powered vehicles emit some 30 to 100 times more particles than do @entity13 engine cars. We previously reported that diesel exhaust particles (DEP) could produce @entity3 anions in an in vitro study. Furthermore, @entity1 instilled intratracheally with DEP showed high mortality at low doses. The cause of @entity2 was @entity0 with damage to the lung endothelial cells. In order to elucidate the mechanism of the onset of mortality induced by DEP, we examined the direct action of DEP on the isolated atrium of @entity4 . A light-duty (2740cc), four cylinder diesel engine was used. The DEP were collected on fiberglass filter. DEP caused a negative inotropic action that was followed by the @entity5 of the isolated left atrium. These actions were not inhibited by @entity6 , @entity10 , @entity8 , @entity12 , @entity11 , @entity9 , @entity3 dismutase or @entity14 . The precise mechanism of @entity5 is unknown. However, these results suggest that @entity7 induced by DEP might be involved in @entity0 .

title: Biological effects of diesel exhaust particles (DEP) on isolated cardiac muscle of XXXX .

answer: @entity4


abstract: 7.5% @entity4 /6% dextran-70 ( @entity7 ) has been shown to be an effective, small volume resuscitation fluid following @entity1 ( @entity1 ) in euhydrated (E) @entity3 . However, there is controversy whether @entity6 solutions would be effective in dehydrated (D) animals. Therefore, we used two groups (E and 4 days D) of chronically instrumented ewes to evaluate the responses to @entity7 following @entity1 . All @entity3 were bled and maintained at 50 mmHg @entity2 ( @entity2 ) for 2 h, then resuscitated with a 4 mL/kg bolus of @entity7 . Dehydration did not affect baseline @entity2 , heart rate (HR), or total peripheral resistance (TPR), whereas cardiac output (CO: E, 5.28 +/- .31; D, 4.00 +/- .31 L/min), @entity0 volume (SV: E, 61 +/- 4; D, 44 +/- 4 mL/beat), urine flow rate (V: E, .51 +/- .11; D, .34 +/- .07 mL/min), and @entity5 excretion (UNa V: E, 22 +/- 8; D, 6 +/- 2 microEq/min) were reduced and plasma @entity5 (PNa: E, 150 +/- 3; D, 157 +/- 2 mEq/L) and protein (PTP E, 7.8 +/- .1; D, 8.8 +/- .6 g/dL) were elevated. The only difference between groups during @entity1 were HR (E, 98 +/- 8; D, 150 +/- 17 bpm), SV (E, 31 +/- 3; D, 14 +/- 2), and TPR (E, 23 +/- 2; D, 32 +/- 3). Resuscitation with @entity7 restored @entity2 (E, 92 +/- 3; D, 92 +/- 2), CO (E, 6.2 +/- .3; D, 4.2 +/- .2), and TPR (E, 15 +/- 1; D, 23 +/- 1) to baseline values. SV was increased above @entity1 values but was not restored to baseline values in either group (E, 50 +/- 7; D, 27 +/- 3). HR increased further following @entity7 (E, 143 +/- 11; D, 158 +/- 5). PNa was raised 10 and 16 mEq/L in the E and @entity3 , respectively, following @entity7 infusion, but no adverse effects associated with elevated PNa were observed in either group. Thus, @entity7 was effective in restoring @entity2 , CO, and TPR to baseline values in @entity3 but it was at the expense of a lower SV and a higher HR than in E @entity3 .

title: Comparison of 7.5% XXXX /6% dextran-70 resuscitation of @entity1 between euhydrated and dehydrated @entity3 .

answer: @entity4


abstract: 7.5% @entity4 /6% dextran-70 ( @entity7 ) has been shown to be an effective, small volume resuscitation fluid following @entity1 ( @entity1 ) in euhydrated (E) @entity3 . However, there is controversy whether @entity6 solutions would be effective in dehydrated (D) animals. Therefore, we used two groups (E and 4 days D) of chronically instrumented ewes to evaluate the responses to @entity7 following @entity1 . All @entity3 were bled and maintained at 50 mmHg @entity2 ( @entity2 ) for 2 h, then resuscitated with a 4 mL/kg bolus of @entity7 . Dehydration did not affect baseline @entity2 , heart rate (HR), or total peripheral resistance (TPR), whereas cardiac output (CO: E, 5.28 +/- .31; D, 4.00 +/- .31 L/min), @entity0 volume (SV: E, 61 +/- 4; D, 44 +/- 4 mL/beat), urine flow rate (V: E, .51 +/- .11; D, .34 +/- .07 mL/min), and @entity5 excretion (UNa V: E, 22 +/- 8; D, 6 +/- 2 microEq/min) were reduced and plasma @entity5 (PNa: E, 150 +/- 3; D, 157 +/- 2 mEq/L) and protein (PTP E, 7.8 +/- .1; D, 8.8 +/- .6 g/dL) were elevated. The only difference between groups during @entity1 were HR (E, 98 +/- 8; D, 150 +/- 17 bpm), SV (E, 31 +/- 3; D, 14 +/- 2), and TPR (E, 23 +/- 2; D, 32 +/- 3). Resuscitation with @entity7 restored @entity2 (E, 92 +/- 3; D, 92 +/- 2), CO (E, 6.2 +/- .3; D, 4.2 +/- .2), and TPR (E, 15 +/- 1; D, 23 +/- 1) to baseline values. SV was increased above @entity1 values but was not restored to baseline values in either group (E, 50 +/- 7; D, 27 +/- 3). HR increased further following @entity7 (E, 143 +/- 11; D, 158 +/- 5). PNa was raised 10 and 16 mEq/L in the E and @entity3 , respectively, following @entity7 infusion, but no adverse effects associated with elevated PNa were observed in either group. Thus, @entity7 was effective in restoring @entity2 , CO, and TPR to baseline values in @entity3 but it was at the expense of a lower SV and a higher HR than in E @entity3 .

title: Comparison of 7.5% @entity4 /6% dextran-70 resuscitation of XXXX between euhydrated and dehydrated @entity3 .

answer: @entity1


abstract: 7.5% @entity4 /6% dextran-70 ( @entity7 ) has been shown to be an effective, small volume resuscitation fluid following @entity1 ( @entity1 ) in euhydrated (E) @entity3 . However, there is controversy whether @entity6 solutions would be effective in dehydrated (D) animals. Therefore, we used two groups (E and 4 days D) of chronically instrumented ewes to evaluate the responses to @entity7 following @entity1 . All @entity3 were bled and maintained at 50 mmHg @entity2 ( @entity2 ) for 2 h, then resuscitated with a 4 mL/kg bolus of @entity7 . Dehydration did not affect baseline @entity2 , heart rate (HR), or total peripheral resistance (TPR), whereas cardiac output (CO: E, 5.28 +/- .31; D, 4.00 +/- .31 L/min), @entity0 volume (SV: E, 61 +/- 4; D, 44 +/- 4 mL/beat), urine flow rate (V: E, .51 +/- .11; D, .34 +/- .07 mL/min), and @entity5 excretion (UNa V: E, 22 +/- 8; D, 6 +/- 2 microEq/min) were reduced and plasma @entity5 (PNa: E, 150 +/- 3; D, 157 +/- 2 mEq/L) and protein (PTP E, 7.8 +/- .1; D, 8.8 +/- .6 g/dL) were elevated. The only difference between groups during @entity1 were HR (E, 98 +/- 8; D, 150 +/- 17 bpm), SV (E, 31 +/- 3; D, 14 +/- 2), and TPR (E, 23 +/- 2; D, 32 +/- 3). Resuscitation with @entity7 restored @entity2 (E, 92 +/- 3; D, 92 +/- 2), CO (E, 6.2 +/- .3; D, 4.2 +/- .2), and TPR (E, 15 +/- 1; D, 23 +/- 1) to baseline values. SV was increased above @entity1 values but was not restored to baseline values in either group (E, 50 +/- 7; D, 27 +/- 3). HR increased further following @entity7 (E, 143 +/- 11; D, 158 +/- 5). PNa was raised 10 and 16 mEq/L in the E and @entity3 , respectively, following @entity7 infusion, but no adverse effects associated with elevated PNa were observed in either group. Thus, @entity7 was effective in restoring @entity2 , CO, and TPR to baseline values in @entity3 but it was at the expense of a lower SV and a higher HR than in E @entity3 .

title: Comparison of 7.5% @entity4 /6% dextran-70 resuscitation of @entity1 between euhydrated and dehydrated XXXX .

answer: @entity3


abstract: In a prospective study at the University of Erlangen, Dept. Gynaecol, and Obstet., 228 @entity1 with @entity0 during their primary surgery and 20 @entity1 during their metastatic surgery, underwent bone marrow punctions at six punction sides, which were twice at the sternum and twice at both iliac crest. The control group was 20 @entity1 without an @entity4 . Aim of the study was to detect or exclude @entity3 cells in the bone marrow via examination of the biopsies with monoclonal antibodies EMA and cytokeratin and consequently to find out the meaning of the results as prognostic criteria by statistical measurements. @entity3 cells in the bone marrow were detected in 46.5% (106/228) of the @entity1 , who underwent a bone marrow biopsy during primary surgery. 21% (23/106) of the @entity1 who were bone marrow positive, but only 5.75% (7/122) of the @entity1 , who were bone marrow negative, developed @entity2 during a median follow-up of 20 months. This difference is statistically significant. 17 of the 30 @entity1 with recurrences developed bone @entity2 ; 16 of them were EMA-positive. The median recurrence-free interval was 5 months in the bone marrow positive group and therefore noticeably shorter, than in the bone marrow negative @entity1 group with 11 months. Of the nodal negative @entity1 , 2 bone marrow positive @entity1 developed distant @entity2 . With the knowledge of the nodal status and bone marrow biopsy result, it was possible to predict 28 of the 30 @entity1 correctly in respect of their risk to metastasize. The result of the @entity5 was proved in a multivariate analysis to be an independent prognostic factor.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Immunocytochemical detection of @entity3 cells in bone marrow as a prognostic factor in XXXX ].

answer: @entity0


abstract: In a prospective study at the University of Erlangen, Dept. Gynaecol, and Obstet., 228 @entity1 with @entity0 during their primary surgery and 20 @entity1 during their metastatic surgery, underwent bone marrow punctions at six punction sides, which were twice at the sternum and twice at both iliac crest. The control group was 20 @entity1 without an @entity4 . Aim of the study was to detect or exclude @entity3 cells in the bone marrow via examination of the biopsies with monoclonal antibodies EMA and cytokeratin and consequently to find out the meaning of the results as prognostic criteria by statistical measurements. @entity3 cells in the bone marrow were detected in 46.5% (106/228) of the @entity1 , who underwent a bone marrow biopsy during primary surgery. 21% (23/106) of the @entity1 who were bone marrow positive, but only 5.75% (7/122) of the @entity1 , who were bone marrow negative, developed @entity2 during a median follow-up of 20 months. This difference is statistically significant. 17 of the 30 @entity1 with recurrences developed bone @entity2 ; 16 of them were EMA-positive. The median recurrence-free interval was 5 months in the bone marrow positive group and therefore noticeably shorter, than in the bone marrow negative @entity1 group with 11 months. Of the nodal negative @entity1 , 2 bone marrow positive @entity1 developed distant @entity2 . With the knowledge of the nodal status and bone marrow biopsy result, it was possible to predict 28 of the 30 @entity1 correctly in respect of their risk to metastasize. The result of the @entity5 was proved in a multivariate analysis to be an independent prognostic factor.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Immunocytochemical detection of XXXX cells in bone marrow as a prognostic factor in @entity0 ].

answer: @entity3


abstract: AIMS: The IMPROVE study evaluated the safety and effectiveness of biphasic insulin aspart 30/70 ( @entity3 ) in type 2 @entity1 @entity0 in the routine practice. Here we present the results for @entity0 from Italy. METHODS: Adverse events, hypoglycaemia, glycaemic control, @entity0 treatment satisfaction and physician resource utilisation were assessed at baseline and 26 weeks. RESULTS: Out of the 1371 @entity0 enrolled, 84.1% (n=1153) were receiving @entity3 at baseline (in accordance with local regulations), and were included in the study. Mean HlbA, reduction was--0.63% after 26 weeks (p < 0.001); 26.5% and 13.5% of @entity0 reached the HbA(1c) targets of < 7% and < 6.5%, respectively. Fasting and postprandial blood @entity2 significantly decreased; 65% of @entity0 were using @entity3 once daily and 32% twice daily at final visit. Rates of major and minor hypoglycaemic events also significantly decreased. Small weight increase was observed, and total insulin daily dose increased from 0.29 IU/kg pre-study to 0.32 IU/kg at final visit. CONCLUSIONS: In Italy, @entity3 in the routine care improved glycaemic control and reduced hypoglycaemia; however, there was little intensification and titration. This may partly explain the relatively small improvement in glycaemic control in Italy compared with other countries in the IMPROVE study.

title: The IMPROVE study--a multinational, multicentre, observational study in type 2 XXXX : results from the Italian cohort.

answer: @entity1


abstract: BACKGROUND/AIM: The optimal management of prenatally diagnosed asymptomatic @entity2 ( @entity2 ) is controversial. Since there is a paucity of data relating to surgical risks in this specific population, we reviewed our experience to further inform this controversy. METHODS: Ethically approved 10 year (2004-2013) retrospective review. @entity0 were included only if the @entity2 was diagnosed prenatally and remained asymptomatic. Indication for surgery was physician recommendation and/or parental choice. MAIN RESULTS: Sixty @entity0 were identified. Median age at surgery was 6.5 months (range 65 days to 9.6 years). Resections were performed thoracoscopically (n   =   51, one conversion) or by thoracotomy (n   =   9). Surgical time was 2.5   hr (43   min to 4.75   hr). A chest drain was used in 58/60 and remained in situ 53   hr (23-108). There were no @entity3 or blood transfusions. All @entity0 were extubated at the end of the procedure with no re-intubations. Post-operative hospitalization was 73.4   hr (23.8   hr to 4.2 days). Overall, complications occurred in 14/60 (23%). Eleven were minor but three were major: tension pneumothorax associated with new presentation of a small previously undiagnosed diaphragmatic hernia 5 days following resection; aggressive @entity1 of the chest wall in the region close to resection 2 years later; and near-fatal hypovolemic @entity5 due to massive @entity4 from a feeding vessel on postoperative day 7. There were no deaths and no cases of @entity6 . CONCLUSION: Resection of prenatally diagnosed asymptomatic @entity2 is associated with a significant risk of complications, which may be life threatening. These data contribute to a balanced discussion of risks and benefits for these @entity0 . Pediatr Pulmonol. 2016;51:525-530.    2015 Wiley Periodicals, Inc.

title: Morbidity after elective resection of prenatally diagnosed asymptomatic XXXX .

answer: @entity2


abstract: The diagnosis of @entity3 is most commonly made today by transrectal ultrasound guided needle biopsy. Often hypoechoic and peripheral zone lesions are the only areas sampled. Recently, we showed that this approach missed a quarter of the @entity1 that would be detected by a systematic biopsy technique. We term these missed @entity1 @entity2 . We reviewed 1,549 systematic sextant prostate needle biopsies, of which 417 @entity1 were detected and subdivided into @entity1 ( @entity1 detected on biopsy of a @entity1 ( @entity1 found only in normal [isoechoic] peripheral zone). We noted in @entity0 with only @entity1 that fewer biopsy cores per prostate revealed @entity1 (mean 1.6 versus 3.0, p < 0.0001) and that these @entity0 had lower serum @entity4 levels (mean 14.4 versus 43.7, p < 0.001). The Gleason scores for the @entity1 were indistinguishable. The pathological staging of @entity1 was also similar. This study suggests that while @entity1 are generally smaller than @entity1 , they do not represent low grade clinically insignificant @entity2 . A systematic approach to performing prostate biopsy is recommended.

title: The significance of XXXX .

answer: @entity3


abstract: BACKGROUND: Many @entity2 are characterized by a mosaic pattern, often with alternating stripes of affected and unaffected skin that follow the lines of Blaschko. These nonrandom patterns may be caused by a postzygotic mutation during embryogenesis. We studied the genetic basis of one @entity1 , @entity6 of the epidermolytic hyperkeratotic type. @entity3 is an @entity2 arising from mutations in the genes for keratin (K) 1 and 10. The offspring of @entity0 with @entity4 may have generalized @entity3 . METHODS: We studied the K1 and @entity5 genes in blood and in the keratinocytes and fibroblasts of lesional and nonlesional skin from three @entity0 with @entity4 and four of their offspring with @entity3 . RESULTS: In the @entity0 with @entity4 , point mutations in 50 percent of the @entity5 alleles of epidermal cells were found in keratinocytes from lesional skin; no mutations were detected in normal skin. This mutation was absent or underrepresented in blood and skin fibroblasts. In the offspring with @entity3 , the same mutations as those in the parents were found in 50 percent of the @entity5 alleles from all cell types examined. CONCLUSIONS: Epidermal nevus of the epidermolytic hyperkeratotic type is a mosaic @entity1 of suprabasal keratin. The correlation of mutations in the @entity5 gene with lesional skin and the correlation of the normal gene with normal skin provide evidence that genetic mosaicism can cause clinical mosaicism.

title: Genetic and clinical mosaicism in a type of XXXX .

answer: @entity6