abstract: A prospective clinical study was carried out to investigate whether endometrial microvessels in @entity0 with @entity3 (HMB) of endometrial origin (HMB-E) are fragile due to low pericyte coverage. Idiopathic HMB-E is characterized by large endothelial cell gaps related to the microvascular overexpression of @entity1 ( @entity1 )-A and @entity1 receptors  1-3. A total of 10  @entity0 with a normal menstrual cycle and a history of HMB of <5  years, and 17  healthy @entity0 with a normal menstrual cycle were recruited from the Karolinska University Hospital. Blood samples were obtained for hormone analysis and coagulation tests. Endometrial biopsies were collected in the proliferative or in the secretory phase. Pericyte coverage was assessed using immunohistochemical staining for smooth muscle actin-a  (SMAa) and by image analysis (microvascular density) of endometrial biopsies from 10  @entity0 with HMB-E and 17  healthy ovulating @entity0 (control subjects). Previously published data on endothelial cell gap size and the expression of @entity1 receptors were used. Although microvascular density did not differ between the @entity0 with HMB-E and the control subjects, the number of SMAa-positive microvessels in the proliferative phase was significantly (P=0.005) lower in the @entity0 with HMB-E than in the control subjects. Moreover, the number of SMAa-positive microvessels in the control subjects was significantly fewer in the secretory (P=0.04) than in the proliferative phase, whereas this number did not differ among the @entity0 with HMB-E regardless of phase. A significant negative correlation was observed between the number of @entity1 -positive microvessels and microvessels with pericyte coverage (r=0.8; P=0.04). Finally, the endothelial cell layer was significantly thicker in the @entity0 with HMB-E than in the control subjects. Thus, the upregulation of @entity1 in idiopathic HMB-E is associated with a low pericyte coverage during the proliferative phase of intense angiogenesis, which may confer @entity4 , possibly leading to excessive @entity2 .

title: Low pericyte coverage of endometrial microvessels in heavy menstrual XXXX correlates with the microvessel expression of @entity1 .

answer: @entity3


abstract: INTRODUCTION: @entity5 ( @entity5 ) involves frequently the kidneys. Lesions encompass mainly @entity3 and @entity2 . The disease can be associated with @entity1 leading to the @entity4 ( @entity4 ) The objectives of the present study were to review the US appearances of the @entity1 in @entity0 affected by classical @entity5 or by the @entity4 and to verify whether it is possible to differentiate between both entities. The evolution of the lesions through time was also studied. MATERIALS AND METHODS: 55 cases of @entity0 <16  years with STB were reviewed by two pediatric radiologists. Clinical data reviewed included age at diagnosis, genetic assessment and complications; US data reviewed included renal size, type of lesions ( @entity3 , or @entity2 ), number and location as well as their evolution with time. Complications were also analyzed. RESULTS: 30 @entity0 (56  %) had at least one @entity1 (27 classical @entity5 and 3 @entity4 ). On the basis of the US findings, these @entity0 were separated into four groups. Group 1 (9 @entity0 ) displayed microscopic (diffuse) AML; group 2 (3 @entity0 ) displayed @entity6 ; group 3 (9 @entity0 ) displayed only @entity1 and group 4 (9 @entity0 ) displayed the association of AML and @entity2 . Increased renal size, the large number and size of @entity7 were suggestive of the @entity4 . The isolated AML were suggestive of classical STB. The average growth of @entity3 was low before age of 12 and exceeded 4  mm/year thereafter. CONCLUSION: In @entity0 with @entity5 , @entity1 is common. Some US criteria can help to suggest the diagnosis of @entity4 . The growth of @entity3 is slow before 12  years and accelerates thereafter. Complications are rare.

title: XXXX in @entity5 complex with emphasis on @entity7 .

answer: @entity1


abstract: INTRODUCTION: @entity5 ( @entity5 ) involves frequently the kidneys. Lesions encompass mainly @entity3 and @entity2 . The disease can be associated with @entity1 leading to the @entity4 ( @entity4 ) The objectives of the present study were to review the US appearances of the @entity1 in @entity0 affected by classical @entity5 or by the @entity4 and to verify whether it is possible to differentiate between both entities. The evolution of the lesions through time was also studied. MATERIALS AND METHODS: 55 cases of @entity0 <16  years with STB were reviewed by two pediatric radiologists. Clinical data reviewed included age at diagnosis, genetic assessment and complications; US data reviewed included renal size, type of lesions ( @entity3 , or @entity2 ), number and location as well as their evolution with time. Complications were also analyzed. RESULTS: 30 @entity0 (56  %) had at least one @entity1 (27 classical @entity5 and 3 @entity4 ). On the basis of the US findings, these @entity0 were separated into four groups. Group 1 (9 @entity0 ) displayed microscopic (diffuse) AML; group 2 (3 @entity0 ) displayed @entity6 ; group 3 (9 @entity0 ) displayed only @entity1 and group 4 (9 @entity0 ) displayed the association of AML and @entity2 . Increased renal size, the large number and size of @entity7 were suggestive of the @entity4 . The isolated AML were suggestive of classical STB. The average growth of @entity3 was low before age of 12 and exceeded 4  mm/year thereafter. CONCLUSION: In @entity0 with @entity5 , @entity1 is common. Some US criteria can help to suggest the diagnosis of @entity4 . The growth of @entity3 is slow before 12  years and accelerates thereafter. Complications are rare.

title: @entity1 in XXXX complex with emphasis on @entity7 .

answer: @entity5


abstract: INTRODUCTION: @entity5 ( @entity5 ) involves frequently the kidneys. Lesions encompass mainly @entity3 and @entity2 . The disease can be associated with @entity1 leading to the @entity4 ( @entity4 ) The objectives of the present study were to review the US appearances of the @entity1 in @entity0 affected by classical @entity5 or by the @entity4 and to verify whether it is possible to differentiate between both entities. The evolution of the lesions through time was also studied. MATERIALS AND METHODS: 55 cases of @entity0 <16  years with STB were reviewed by two pediatric radiologists. Clinical data reviewed included age at diagnosis, genetic assessment and complications; US data reviewed included renal size, type of lesions ( @entity3 , or @entity2 ), number and location as well as their evolution with time. Complications were also analyzed. RESULTS: 30 @entity0 (56  %) had at least one @entity1 (27 classical @entity5 and 3 @entity4 ). On the basis of the US findings, these @entity0 were separated into four groups. Group 1 (9 @entity0 ) displayed microscopic (diffuse) AML; group 2 (3 @entity0 ) displayed @entity6 ; group 3 (9 @entity0 ) displayed only @entity1 and group 4 (9 @entity0 ) displayed the association of AML and @entity2 . Increased renal size, the large number and size of @entity7 were suggestive of the @entity4 . The isolated AML were suggestive of classical STB. The average growth of @entity3 was low before age of 12 and exceeded 4  mm/year thereafter. CONCLUSION: In @entity0 with @entity5 , @entity1 is common. Some US criteria can help to suggest the diagnosis of @entity4 . The growth of @entity3 is slow before 12  years and accelerates thereafter. Complications are rare.

title: @entity1 in @entity5 complex with emphasis on XXXX .

answer: @entity7


abstract: UNASSIGNED: The fate of organic pollutants in the environment is influenced by several factors including the type and strength of their interactions with soil components especially SOM. However, a molecular level answer to the question "How organic pollutants interact with SOM?" is still lacking. In order to explore mechanisms of this interaction, we have developed a new SOM model and carried out @entity0 ( @entity0 ) simulations in parallel with sorption experiments. The new SOM model comprises free SOM functional groups ( @entity1 and @entity3 ) as well as SOM cavities (with two different sizes), simulating the soil voids, containing the same SOM functional groups. To examine the effect of the hydrophobicity on the interaction, the organic pollutants @entity4 ( @entity4 , non-polar) and @entity2 (SAA, polar) were considered. The experimental and theoretical investigations explored four major points regarding sorption of SAA and @entity4 on soil, yielding the following results. 1-The interaction depends on the SOM chemical composition more than the SOM content. 2-The interaction causes a site-specific adsorption on the soil surfaces. 3-Sorption hysteresis occurs, which can be explained by inclusion of these pollutants inside soil voids. 4-The hydrophobic @entity4 is adsorbed on soil stronger than the hydrophilic SAA. Moreover, the theoretical results showed that @entity4 forms stable complexes with all SOM models in the aqueous solution, while most of SAA-SOM complexes are accompanied by dissociation into SAA and the free SOM models. The SOM-cavity modeling had a significant effect on binding of organic pollutants to SOM. Both @entity4 and SAA bind to the SOM models in the order of models with a small cavity>a large cavity>no cavity. Although @entity4 binds to all SOM models stronger than SAA, the latter is more affected by the presence of the cavity. Finally, @entity4 and SAA bind to the hydrophobic functional group ( @entity3 ) stronger than to the hydrophilic one ( @entity1 ) for all SOM models containing a cavity. For models without a cavity, SAA binds to @entity1 stronger than to @entity3 .

title: Interaction of polar and nonpolar organic pollutants with soil organic matter: Sorption experiments and XXXX simulation.

answer: @entity0


abstract: UNASSIGNED: @entity2 is the leading cause of @entity3 with ~80% being @entity1 . Stem cell transplantation has been shown to improve functional recovery. However, the overall survival and differentiation of these cells is still low. The @entity4 is an ideal location for transplantation as it is directly adjacent to the highly plastic peri- @entity4 region. Direct transplantation of cells near the @entity4 has resulted in low cell viability. Here we deliver neural progenitor cells derived from induce pluripotent stem cells (iPS-NPC) to the @entity4 of stroked @entity0 encapsulated in a hyaluronic acid hydrogel matrix to protect the cells. To improve the overall viability of transplanted cells, each step of the transplantation process was optimized. Hydrogel mechanics and cell injection parameters were investigated to determine their effects on the inflammatory response of the brain and cell viability, respectively. Using parameters that balanced the desire to keep surgery invasiveness minimal and cell viability high, iPS-NPCs were transplanted to the @entity2 cavity of @entity0 encapsulated in buffer or the hydrogel. While the hydrogel did not promote stem cell survival one week post-transplantation, it did promote differentiation of the neural progenitor cells to neuroblasts.

title: Delivery of iPS-NPCs to the XXXX Cavity within a Hyaluronic Acid Matrix Promotes the Differentiation of Transplanted Cells.

answer: @entity2


abstract: BACKGROUND: A new @entity4 ( @entity4 ) product adsorbed on @entity5 has been developed with a short and simplified up-dosing phase, containing a biologically standardized allergen pollen extract from @entity3 . OBJECTIVE: To assess the tolerability profile of the updosing phase and its immunological effect, in terms of specific IgG4 and IgE levels and immediate skin reactivity. MATERIAL AND METHODS: The study was an exploratory, multi-centre, open-label, single-arm, phase II/III clinical trial. Adults with a clinical history of @entity1 with/without @entity2 due to sensitization to olive pollen were selected. Five up-dosing doses (300, 600, 3000, 6000 and 15000SQ+) were administered at weekly intervals, followed by a maintenance dose (15000SQ+) after 2  weeks. Adverse events were collected during the 30  min observation period after injections, after a telephone contact 2  days after each visit, and after reviewing the subjects' diary. IgG4 and IgE levels and immediate skin reactivity were evaluated at the beginning and at the end of the trial. RESULTS: Ninety-three subjects were included in the trial (mean age, 35.7        10.3  years; @entity0 , 66.7  %). A total of 95 adverse drug reactions, all mild in intensity and non-serious, were reported during the trial: 85 local in 34.4  % subjects, 9 systemic in 4.3  % subjects and one non-specific (grade 0). Within 6  weeks, significant changes in IgG4 and IgE levels and in immediate skin reactivity to @entity3 were accomplished. CONCLUSION: This new @entity4 derived from pollen of @entity3 presented a good tolerability profile and induced significant immunological responses already after a 6  week treatment. However, the non-controlled design may limit the interpretation of these results. TRIAL REGISTRATION: EudraCT no: 2011-004852-20; ClinicalTrials.gov Identifier: NCT01674595.

title: Exploratory study of tolerability and immunological effect of a short up-dosing immunotherapy phase with a standardised allergen extract derived from pollen of XXXX .

answer: @entity3


abstract: BACKGROUND: @entity9 ( @entity9 ) constitutes a spectrum of @entity4 associated with @entity2 . The clinical heterogeneity is evident, and early diagnosis is a challenge. The primary objectives were to characterize @entity6 , initial clinical diagnoses and family history in neuropathologically verified @entity9 - @entity0 and to analyze possible correlations with different neuropathological findings. METHODS: The medical records of 97 consecutive @entity0 with a neuropathological diagnosis of @entity7 ( @entity7 ) were reevaluated. Psychotic symptoms ( @entity8 , delusions, @entity10 ), initial diagnosis and family history for @entity3 were analyzed. RESULTS: Psychotic symptoms were present in 31 @entity0 (32%). There were no significant differences in age at onset, disease duration or gender between @entity0 with and without @entity6 . Paranoid ideas were seen in 20.6%, and @entity8 and delusions in 17.5% in equal measure. Apart from a strong correlation between @entity6 and predominantly right-sided @entity2 , the majority of @entity0 (77.4%) were tau-negative. Only 14.4% of the @entity0 were initially diagnosed as @entity9 , while other types of @entity5 were seen in 34%, other @entity3 in 42%, and 9.2% with other @entity1 . The @entity0 who were initially diagnosed with a @entity3 were significantly younger than the @entity0 with other initial clinical diagnoses. A positive heredity for @entity5 or other @entity3 was seen in 42% and 26% of the @entity0 respectively. CONCLUSIONS: Psychotic symptoms, not covered by current diagnostic criteria, are common and may lead to clinical misdiagnosis in @entity9 .

title: Psychotic symptoms in XXXX : a diagnostic dilemma?

answer: @entity9


abstract: Communication difficulties in @entity1 ( @entity1 ) with @entity2 @entity0 have been well documented for more than three decades. However, there is only a paucity of literature that has explored communication difficulties beyond the @entity1 environment. This paper discusses the experience of communication difficulties in @entity2 @entity0 in @entity1 and beyond as part of findings from a larger study that explored the lived experiences of @entity2 @entity0 in @entity1 in the context of daily sedation interruption (DSI). The aim of the study was to describe the lived experience of @entity0 who experienced @entity2 in @entity1 using a hermeneutic phenomenological approach in the DSI context. Twelve @entity0 aged between 20 and 76 years with an @entity1 stay ranging from 3 to 36 days were recruited from a 16 bed @entity1 in a large regional referral hospital in New South Wales (NSW), Australia. @entity0 were intubated, mechanically ventilated and subjected to (DSI) during their @entity2 in @entity1 . In-depth face to face interviews with @entity0 were conducted at two weeks after discharge from @entity1 and at six to eleven months later. Interviews were audio taped and transcribed. Thematic analysis using van Manen's (1990) method was completed. The overarching theme; 'Being in limbo' and subthemes 'Being disrupted'; 'Being imprisoned' and 'Being trapped' depict the main elements of the experience. This paper discusses communication difficulties in @entity2 @entity0 as one of the main findings relating to the theme 'Being trapped'. @entity0 ' reports of communication difficulties in @entity1 are similar to those reported by @entity0 in other studies where DSI was not used. However, not many studies have reported ongoing communication difficulties after @entity1 hospitalisation. Recommendations are made for new models of care and support to mitigate @entity2 @entity0 ' communication concerns in @entity1 and for further research into the causes and treatment to benefit this group of @entity0 . Most importantly, extra care is recommended not to damage vocal cords during intubation and cuff inflation in the course of mechanical ventilation.

title: The experience of communication difficulties in XXXX @entity0 in and beyond intensive care: Findings from a larger phenomenological study.

answer: @entity2


abstract: Communication difficulties in @entity1 ( @entity1 ) with @entity2 @entity0 have been well documented for more than three decades. However, there is only a paucity of literature that has explored communication difficulties beyond the @entity1 environment. This paper discusses the experience of communication difficulties in @entity2 @entity0 in @entity1 and beyond as part of findings from a larger study that explored the lived experiences of @entity2 @entity0 in @entity1 in the context of daily sedation interruption (DSI). The aim of the study was to describe the lived experience of @entity0 who experienced @entity2 in @entity1 using a hermeneutic phenomenological approach in the DSI context. Twelve @entity0 aged between 20 and 76 years with an @entity1 stay ranging from 3 to 36 days were recruited from a 16 bed @entity1 in a large regional referral hospital in New South Wales (NSW), Australia. @entity0 were intubated, mechanically ventilated and subjected to (DSI) during their @entity2 in @entity1 . In-depth face to face interviews with @entity0 were conducted at two weeks after discharge from @entity1 and at six to eleven months later. Interviews were audio taped and transcribed. Thematic analysis using van Manen's (1990) method was completed. The overarching theme; 'Being in limbo' and subthemes 'Being disrupted'; 'Being imprisoned' and 'Being trapped' depict the main elements of the experience. This paper discusses communication difficulties in @entity2 @entity0 as one of the main findings relating to the theme 'Being trapped'. @entity0 ' reports of communication difficulties in @entity1 are similar to those reported by @entity0 in other studies where DSI was not used. However, not many studies have reported ongoing communication difficulties after @entity1 hospitalisation. Recommendations are made for new models of care and support to mitigate @entity2 @entity0 ' communication concerns in @entity1 and for further research into the causes and treatment to benefit this group of @entity0 . Most importantly, extra care is recommended not to damage vocal cords during intubation and cuff inflation in the course of mechanical ventilation.

title: The experience of communication difficulties in @entity2 XXXX in and beyond intensive care: Findings from a larger phenomenological study.

answer: @entity0


abstract: Chemotherapy is a widely adopted method for the treatment of @entity1 . However, its use is often limited due to side effects produced by anti- @entity1 drugs. Therefore, various drug carriers, including polymeric micelles, have been investigated to find a method to overcome this limitation. In this study, alginate-based, self-assembled polymeric micelles were designed and prepared using alginate-g- @entity4 ( @entity4 ). Amino-PNIPAAm was chemically introduced to the alginate backbone via @entity5 chemistry. The resulting polymer was dissolved in distilled water at room temperature and formed self-assembled micelles at 37   C. Characteristics of alginate-g- @entity4 micelles were dependent on the molecular weight of @entity4 , the degree of substitution, and the polymer concentration. @entity3 (DOX), a model anti- @entity1 drug, was efficiently encapsulated in alginate-g- @entity4 micelles, and sustained release of DOX from the micelles was achieved at 37   C in vitro. These micelles accumulated at the @entity1 site of a @entity1 -bearing @entity2 model as a result of the enhanced permeability and retention effect. Interestingly, DOX-loaded alginate-g- @entity4 micelles showed excellent anti- @entity1 therapeutic efficacy in a @entity2 model without any significant side effects. This approach to designing and tailoring natural polymer-based systems to fabricate nanoparticles at @entity0 body temperature may provide a useful means for @entity1 imaging and therapy.

title: XXXX -Loaded Alginate-g- @entity4 Micelles for Cancer Imaging and Therapy.

answer: @entity3


abstract: Chemotherapy is a widely adopted method for the treatment of @entity1 . However, its use is often limited due to side effects produced by anti- @entity1 drugs. Therefore, various drug carriers, including polymeric micelles, have been investigated to find a method to overcome this limitation. In this study, alginate-based, self-assembled polymeric micelles were designed and prepared using alginate-g- @entity4 ( @entity4 ). Amino-PNIPAAm was chemically introduced to the alginate backbone via @entity5 chemistry. The resulting polymer was dissolved in distilled water at room temperature and formed self-assembled micelles at 37   C. Characteristics of alginate-g- @entity4 micelles were dependent on the molecular weight of @entity4 , the degree of substitution, and the polymer concentration. @entity3 (DOX), a model anti- @entity1 drug, was efficiently encapsulated in alginate-g- @entity4 micelles, and sustained release of DOX from the micelles was achieved at 37   C in vitro. These micelles accumulated at the @entity1 site of a @entity1 -bearing @entity2 model as a result of the enhanced permeability and retention effect. Interestingly, DOX-loaded alginate-g- @entity4 micelles showed excellent anti- @entity1 therapeutic efficacy in a @entity2 model without any significant side effects. This approach to designing and tailoring natural polymer-based systems to fabricate nanoparticles at @entity0 body temperature may provide a useful means for @entity1 imaging and therapy.

title: @entity3 -Loaded Alginate-g- XXXX Micelles for Cancer Imaging and Therapy.

answer: @entity4


abstract: BACKGROUND: Immunofluorescence antigen mapping (IFM), is a newly introduced technique for diagnosis and @entity2 (EB) disease. The precise level of skin cleavage can be determined using monoclonal antibodies to EB-specific basement membrane zone protein. OBJECTIVE: To apply IFM technique in diagnosis and classification of EB and to identify utility and limitation of this method in our clinical setting. METHODS: IFM was done according to a described protocol by Pohla-Gubo et al. Monoclonal antibodies used for antigen mapping were against @entity3 , @entity6 , a6 integrin, b4 integrin, laminin 332, Collagen IV, and Collagen VII. RESULTS: IFM was done for 95 referred @entity0 , compromising 49 females and 46 males, aged 5 days to 45 years (mean = 9.5 years). Ninety cases were diagnosed with EB and classified as follows: EB simplex: (n = 13), junctional EB (n = 14), @entity4 (n = 62), and @entity1 (n = 1). Diagnosis was not made in five cases as their specimens contained no @entity5 . Confirmatory genetic analysis was done for five junctional cases from two families with clinical features of @entity8 . Genetic molecular studies showed nonsense mutations in the last codon of exon 39 of the laminin a3a ( @entity7 ) gene ( @entity9 ) and a donor splice site mutation in @entity7 ( @entity10 ) in the first and second family, respectively. CONCLUSION: IFM technique is relatively simple to perform, and interpretation of the results is not sophisticated. The proportion of inconclusive results will be decreased if the specimens contain freshly induced @entity5 .

title: Using immunofluorescence (antigen) mapping in the diagnosis and XXXX : a first report from Iran.

answer: @entity2


abstract: BACKGROUND: Asymptomatic or silent @entity4 (S-PE) in @entity0 with @entity3 has been the focus of numerous publications with the objective of determining the incidence of S-PE and assessing whether its existence has any clinical or therapeutic consequences that outweigh the risks associated with the diagnostic tests performed and the increased healthcare costs. The objectives were to assess the incidence of S-PE using computed tomography angiogram (CTA), to understand the epidemiological factors that might trigger @entity2 , and to assess whether @entity5 ( @entity5 ) predicts the existence of S-PE's. METHODS: A prospective and consecutive assessment of 103 hospitalized @entity0 with lower limb @entity6 in the absence of PE symptoms, using CT scan. @entity5 was quantified before anticoagulation. The risk factors and characteristics of the @entity6 were studied. A three-year follow-up assessing risk recurrence and clinical outcome was performed. RESULTS: The incidence of S-PE was 66%. In 77% of these cases, the main and lobar pulmonary arteries were affected. Iliac and femoral DVTs most often produced S-PE. ROC curve with a @entity5 value higher than 578  ng/ml provided good sensitivity but low specificity to identify @entity0 with S-PE. Diagnosis entailed higher hospitalization expenses. No significant recurrence rate of @entity1 events was observed in the S-PE group during the follow-up. CONCLUSIONS: The incidence of S-PE in lower-limb @entity6 is high, but in the absence of symptoms, diagnosis does not appear to be necessary, as there are no short- or long-term clinical or therapeutic consequences.

title: Should we look for silent XXXX in @entity0 with @entity3 ?

answer: @entity4


abstract: BACKGROUND: Asymptomatic or silent @entity4 (S-PE) in @entity0 with @entity3 has been the focus of numerous publications with the objective of determining the incidence of S-PE and assessing whether its existence has any clinical or therapeutic consequences that outweigh the risks associated with the diagnostic tests performed and the increased healthcare costs. The objectives were to assess the incidence of S-PE using computed tomography angiogram (CTA), to understand the epidemiological factors that might trigger @entity2 , and to assess whether @entity5 ( @entity5 ) predicts the existence of S-PE's. METHODS: A prospective and consecutive assessment of 103 hospitalized @entity0 with lower limb @entity6 in the absence of PE symptoms, using CT scan. @entity5 was quantified before anticoagulation. The risk factors and characteristics of the @entity6 were studied. A three-year follow-up assessing risk recurrence and clinical outcome was performed. RESULTS: The incidence of S-PE was 66%. In 77% of these cases, the main and lobar pulmonary arteries were affected. Iliac and femoral DVTs most often produced S-PE. ROC curve with a @entity5 value higher than 578  ng/ml provided good sensitivity but low specificity to identify @entity0 with S-PE. Diagnosis entailed higher hospitalization expenses. No significant recurrence rate of @entity1 events was observed in the S-PE group during the follow-up. CONCLUSIONS: The incidence of S-PE in lower-limb @entity6 is high, but in the absence of symptoms, diagnosis does not appear to be necessary, as there are no short- or long-term clinical or therapeutic consequences.

title: Should we look for silent @entity4 in @entity0 with XXXX ?

answer: @entity3


abstract: BACKGROUND: Asymptomatic or silent @entity4 (S-PE) in @entity0 with @entity3 has been the focus of numerous publications with the objective of determining the incidence of S-PE and assessing whether its existence has any clinical or therapeutic consequences that outweigh the risks associated with the diagnostic tests performed and the increased healthcare costs. The objectives were to assess the incidence of S-PE using computed tomography angiogram (CTA), to understand the epidemiological factors that might trigger @entity2 , and to assess whether @entity5 ( @entity5 ) predicts the existence of S-PE's. METHODS: A prospective and consecutive assessment of 103 hospitalized @entity0 with lower limb @entity6 in the absence of PE symptoms, using CT scan. @entity5 was quantified before anticoagulation. The risk factors and characteristics of the @entity6 were studied. A three-year follow-up assessing risk recurrence and clinical outcome was performed. RESULTS: The incidence of S-PE was 66%. In 77% of these cases, the main and lobar pulmonary arteries were affected. Iliac and femoral DVTs most often produced S-PE. ROC curve with a @entity5 value higher than 578  ng/ml provided good sensitivity but low specificity to identify @entity0 with S-PE. Diagnosis entailed higher hospitalization expenses. No significant recurrence rate of @entity1 events was observed in the S-PE group during the follow-up. CONCLUSIONS: The incidence of S-PE in lower-limb @entity6 is high, but in the absence of symptoms, diagnosis does not appear to be necessary, as there are no short- or long-term clinical or therapeutic consequences.

title: Should we look for silent @entity4 in XXXX with @entity3 ?

answer: @entity0


abstract: BACKGROUND: In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has recently focused on the link between environmental pollution and @entity3 . Nanoparticles <50  nm in size are known to pass the alveolar-pulmonary barrier, enter into bloodstream and induce @entity1 , but the direct pathogenic mechanisms still need to be evaluated. We thus focused our attention on @entity8 ( @entity7 ) nanoparticles, the most diffuse nanomaterial in polluted environments and one generally considered inert for the @entity0 body. METHODS: We conducted functional studies on isolated adult @entity2 cardiomyocytes exposed acutely in vitro to @entity7 and on healthy @entity2 administered a single dose of 2  mg/Kg @entity7 NPs via the @entity5 . Transmission electron microscopy was used to verify the actual presence of @entity7 nanoparticles within cardiac tissue, toxicological assays were used to assess lipid peroxidation and DNA tissue damage, and an in silico method was used to model the effect on action potential. RESULTS: Ventricular myocytes exposed in vitro to @entity7 had significantly reduced action potential duration, @entity4 and decreased stability of resting membrane potential. In vivo, a single intra-tracheal administration of saline solution containing @entity7 nanoparticles increased cardiac conduction velocity and tissue excitability, resulting in an enhanced propensity for inducible @entity6 . Computational modeling of ventricular action potential indicated that a membrane leakage could account for the nanoparticle-induced effects measured on real cardiomyocytes. CONCLUSIONS: Acute exposure to @entity7 nanoparticles acutely alters cardiac excitability and increases the likelihood of arrhythmic events.

title: @entity8 nanoparticles promote XXXX via a direct interaction with @entity2 cardiac tissue.

answer: @entity6


abstract: BACKGROUND: In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has recently focused on the link between environmental pollution and @entity3 . Nanoparticles <50  nm in size are known to pass the alveolar-pulmonary barrier, enter into bloodstream and induce @entity1 , but the direct pathogenic mechanisms still need to be evaluated. We thus focused our attention on @entity8 ( @entity7 ) nanoparticles, the most diffuse nanomaterial in polluted environments and one generally considered inert for the @entity0 body. METHODS: We conducted functional studies on isolated adult @entity2 cardiomyocytes exposed acutely in vitro to @entity7 and on healthy @entity2 administered a single dose of 2  mg/Kg @entity7 NPs via the @entity5 . Transmission electron microscopy was used to verify the actual presence of @entity7 nanoparticles within cardiac tissue, toxicological assays were used to assess lipid peroxidation and DNA tissue damage, and an in silico method was used to model the effect on action potential. RESULTS: Ventricular myocytes exposed in vitro to @entity7 had significantly reduced action potential duration, @entity4 and decreased stability of resting membrane potential. In vivo, a single intra-tracheal administration of saline solution containing @entity7 nanoparticles increased cardiac conduction velocity and tissue excitability, resulting in an enhanced propensity for inducible @entity6 . Computational modeling of ventricular action potential indicated that a membrane leakage could account for the nanoparticle-induced effects measured on real cardiomyocytes. CONCLUSIONS: Acute exposure to @entity7 nanoparticles acutely alters cardiac excitability and increases the likelihood of arrhythmic events.

title: XXXX nanoparticles promote @entity6 via a direct interaction with @entity2 cardiac tissue.

answer: @entity8


abstract: BACKGROUND: In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has recently focused on the link between environmental pollution and @entity3 . Nanoparticles <50  nm in size are known to pass the alveolar-pulmonary barrier, enter into bloodstream and induce @entity1 , but the direct pathogenic mechanisms still need to be evaluated. We thus focused our attention on @entity8 ( @entity7 ) nanoparticles, the most diffuse nanomaterial in polluted environments and one generally considered inert for the @entity0 body. METHODS: We conducted functional studies on isolated adult @entity2 cardiomyocytes exposed acutely in vitro to @entity7 and on healthy @entity2 administered a single dose of 2  mg/Kg @entity7 NPs via the @entity5 . Transmission electron microscopy was used to verify the actual presence of @entity7 nanoparticles within cardiac tissue, toxicological assays were used to assess lipid peroxidation and DNA tissue damage, and an in silico method was used to model the effect on action potential. RESULTS: Ventricular myocytes exposed in vitro to @entity7 had significantly reduced action potential duration, @entity4 and decreased stability of resting membrane potential. In vivo, a single intra-tracheal administration of saline solution containing @entity7 nanoparticles increased cardiac conduction velocity and tissue excitability, resulting in an enhanced propensity for inducible @entity6 . Computational modeling of ventricular action potential indicated that a membrane leakage could account for the nanoparticle-induced effects measured on real cardiomyocytes. CONCLUSIONS: Acute exposure to @entity7 nanoparticles acutely alters cardiac excitability and increases the likelihood of arrhythmic events.

title: @entity8 nanoparticles promote @entity6 via a direct interaction with XXXX cardiac tissue.

answer: @entity2


abstract: BACKGROUND: Genomic aberration is a common feature of @entity0 @entity2 and also is one of the basic mechanisms that lead to overexpression of oncogenes and underexpression of @entity2 suppressor genes. Our study aims to identify frequent genomic changes in @entity5 . MATERIALS AND METHODS: We used array comparative genomic hybridization (array CGH) to identify recurrent genomic alterations and validated the protein expression of selected genes by immunohistochemistry. RESULTS: Sixteen gains and thirty-two losses occurred in more than 30% and 60% of the @entity2 , respectively. High-level amplifications at 7q21.3-q22.1 and 19q13.2 and homozygous deletions at 1p33-p32.3, 1p22.1, 1q22, 3q27.2, 6p22.3, 6p21.31, 12q13.2, 17p13.2, 17q21.31 and 22q13.1 were identified. Especially, amplification of @entity9 was detected in two @entity4 and homozygous deletion of @entity11 in other two cases. In 15 independent validation samples, we found that @entity9 (19q13.2) and @entity7 (7q22.1) were amplified in 6 and 9 cases, and @entity13 (17p13.2) and @entity12 (17p13.2) were homozygously deleted in 3 and 1 cases. @entity9 and @entity7 were overexpressed, and @entity13 and @entity12 were underexpressed in @entity5 tissues than in morphologically normal operative margin tissues. Both GISTIC and Genomic Workbench software identified 22q13.1 containing @entity14 and @entity10 as the only homozygous deletion region. And the expression levels of @entity14 and @entity10 were significantly lower in @entity2 tissues than in morphologically normal operative margin tissues. Further validation showed that overexpression of @entity8 was significantly associated with lymph node @entity1 , and overexpression of @entity6 was significantly associated with invasive depth of @entity5 . CONCLUSION: These recurrent genomic changes may be useful for revealing the mechanism of pancreatic @entity3 and providing candidate biomarkers.

title: Identification of genomic alterations in XXXX using array-based comparative genomic hybridization.

answer: @entity5


abstract: BACKGROUND: Solid @entity1 (SPTs) are rare neoplasms of the pancreas. We describe the features of these small @entity1 identified on routine screening sonographic (US) examination and the potential value of using contrast-enhanced ultrasound (CEUS) scanning. METHODS: We retrospectively reviewed records from 17 @entity0 who had undergone screening via US examination at Peking University Third Hospital between January 2000 and June 2011. Each of these @entity0 had been confirmed by a pathologist to have an SPT. Six @entity0 had undergone CEUS prior to surgery. We recorded all features on both gray-scale US and CEUS. RESULTS: All @entity0 (4 @entity0 and 13 @entity0 ; ages 23-35 years; mean age, 27.2 years) were initially screened by US. The largest mass identified was 5.0 cm in diameter (mean diameter, 4.2 cm), and most @entity1 showed homogeneous hypoechogenicity. A hyperechoic rim was detected in four masses. CEUS showed peripheral-rim hyperenhancement in the arterial phase of all six masses. CONCLUSIONS: Routine screening US examinations are capable of identifying small (<5.0 cm) SPTs. These screening examinations allow diagnosis on the basis of typical imaging features, such as a homogeneously hypoechoic mass with a hyperechoic rim. CEUS shows greater detail of the rim and cystic areas in the @entity1 , which significantly improves the proper diagnosis.    2014 Wiley Periodicals, Inc. J Clin Ultrasound, 2014.

title: Solid XXXX of the pancreas: Findings from routine screening sonographic examination and the value of contrast-enhanced ultrasound.

answer: @entity1


abstract: OBJECTIVE: Increased local skin temperature is a classic sign of @entity3 , repetitive @entity2 , and deep @entity1 . Noncontact infrared thermometers can help to detect increases in skin surface temperatures; however, most scientifically tested devices are far too expensive for everyday wound care providers to use in routine clinical practice. This noninferiority study was conducted in an attempt to determine whether 4 less expensive, commercially available noncontact infrared thermometers have a similar level of accuracy as the scientifically accepted Exergen DermaTemp 1001 (Exergen Products, Watertown, Massachusetts). DESIGN, SETTING, AND @entity0 : Using an observational study design, @entity0 with open wounds were randomly selected from a chronic wound clinic (n = 108). Demographic data and wound location were documented for all @entity0 . Skin temperatures were recorded using 5 noncontact infrared thermometers under consistent environmental conditions. The thermometer brands were as follows: Exergen DermaTemp, Mastercool MSC52224-A (Mastercool Inc, Randolph, New Jersey), ATD Tools 70001 Infrared Thermometer (ATD Tools Inc, Wentzville, Missouri), Mastercraft Digital Temperature Reader (Mastercraft Canada, Toronto, Ontario, Canada), and Pro Point Infrared Thermometer (Princess Auto, Winnipeg, Manitoba, Canada). Data analysis was based on the skin surface temperature difference (  T in degrees Fahrenheit) between the wound site and an equivalent contralateral control site. OUTCOME MEASURES: One-way analysis of variance was used to compare the mean   T values for all the 5 thermometers, followed by post hoc analysis. Demographic data were analyzed using descriptive statistics. Interrater reliability was assessed for consistency using the intraclass correlation coefficient. MAIN RESULTS: No statistical difference was reported between the   T values for the 5 different thermometers (F4,514 = 0.339, P = .852). Post hoc analysis showed no significant difference when the thermometers were compared with the Exergen DermaTemp 1001, and Mastercool MSC52224-A (P = .987), ATD Tools 70001 Infrared Thermometer (P = .985), Mastercraft Digital Temperature Reader (P = .972), and Pro Point Infrared Thermometer (P = .774). The results for intraclass correlation demonstrated a high reliability and agreement between raters, as the intraclass correlation coefficient values for all thermometers were greater than 0.95. CONCLUSIONS: The results of this study demonstrate that less expensive, industrial-grade noncontact infrared thermometers have reliable temperature readings to identify and quantify the temperature gradients that along with other signs may be associated with deep and surrounding @entity3 or tissue injury due to repeated microtrauma.

title: Validation of commercially available infrared thermometers for measuring skin surface temperature associated with deep and surrounding XXXX .

answer: @entity3


abstract: UNASSIGNED: The present study investigated whether established fibroproliferative changes in the irradiated @entity1 lung are histopathologically reduced by an adenovirus  -mediated soluble transforming growth factor (TGF)  - @entity5 receptor. Replication  -defective adenoviral vectors expressing a type  II @entity0 @entity3 receptor (AdTb  -ExR) were prepared. Male Fisher  -344 @entity1 were divided into the C, R and R  +  T groups. The @entity1 in the C group did not receive irradiation or treatment. The @entity1 in the R and R  +  T group each received 30  Gy irradiation to the right lung. Eight weeks following irradiation, the @entity1 in the R and R  +  T group were treated with saline or AdTb  -ExR, respectively. To analyze the @entity3 expression, myofibroblast proliferation and macrophage/monocyte infiltration, sections of the lung were immunohistochemically stained at 16 weeks following irradiation. @entity2 staining was performed for semi  -quantitative evaluation of the fibroproliferative changes. Definitive @entity3 expression, myofibroblast proliferation and macrophage/monocyte infiltration were observed in the lungs of the R group, but were significantly lower in the lungs of the R  +  T group. With respect to the fibroproliferative changes, the proportion of red  -stained areas in the R  +  T group was markedly lower than that in the R group. These data indicate that fibroproliferative changes induced by radiation are reversible and that @entity3 has a critical role in fibroproliferative changes in the irradiated lung. The present results suggest that gene therapy with an adenoviral vector expressing a soluble @entity3 receptor may be effective in reducing the established @entity4 caused by radiation.

title: Reduction of fibroproliferative changes in irradiated XXXX lung with soluble transforming growth factor-b receptor.

answer: @entity1


abstract: UNASSIGNED: The syndrome of inappropriate secretion of thyrotropin (SITSH) is a hallmark of resistance to thyroid hormone (RTH) due to mutations in the b isoform of the thyroid hormone receptor ( @entity3 ). Here, we report on a family of RTH due to a @entity3 mutation (RTHb) and presenting occasional SITSH. The proband was a 16 year-old @entity0 with a @entity2 , detected at a school physical examination. She was initially diagnosed as having euthyroid @entity1 because her thyroid function was normal with a positive anti-thyroglobulin antibody. Follow-up examinations resulted in mild SITSH on some occasions and euthyroid on the other occasions. A magnetic resonance imaging (MRI) revealed a normal pituitary gland. Because her mother also had mild SITSH, genetic analysis was performed and revealed a heterozygous point mutation in @entity3 ( @entity4 ). Previously, the @entity4 had only been found in severe RTH cases with homozygous mutations or with an ectopic thyroid. Her mother with a heterozygous mutation showed variable RTH phenotype on T3 suppression testing. In conclusion, the prevalence of RTHb might be underestimated and occasional SITSH could also suggest RTHb. @entity3 gene mutation is not always correlated with the RTH phenotype.

title: A family of RTHb with XXXX mutation presenting occasional syndrome of inappropriate secretion of TSH.

answer: @entity4


abstract: BACKGROUND: Regulatory T-cells (Tregs) have a pivotal role not only in abrogating @entity3 , but also in @entity1 immune escape. The purpose of the present study was to evaluate the clinical significance of the relative expression of forkhead/winged helix transcription factor ( @entity2 ) and micrometastasis in the regional lymph nodes (RLNs) of @entity0 with stage I @entity4 ( @entity4 ). MATERIALS AND METHODS: The RLNs in 131 @entity0 who underwent complete surgical resection for stage I @entity4 were collected at the time of surgery. The relative expression levels of @entity2 and @entity5 ( @entity5 ) in RLNs were determined by quantitative RT-PCR. RESULTS: The pathological stage was diagnosed as stage IA in 97 @entity0 (74.0%) and stage IB in 34 @entity0 (26.0%). The relative expression levels of @entity2 and @entity5 in the RLNs were 0.062  0.0083% and 0.025  0.056%, respectively. The relative expression of @entity2 tended to increase with increasing relative expression of @entity5 . The five-year overall survival rate of the @entity0 with low expression of @entity2 was better (90.3%) than that of @entity0 with high expression (79.3%) (p=0.0419). A multivariate analysis using the significant variables (gender, age, histology and @entity2 expression) showed that the @entity2 expression in RLNs was a significant independent prognostic factor. CONCLUSION: The expression of @entity5 tended to be positively correlated with the expression of @entity2 . High expression of @entity2 in RLNs was a significant unfavorable prognostic factor in @entity0 with stage I @entity4 .

title: Regulatory T-Cells and Micrometastasis in Lymph Nodes of Stage I XXXX .

answer: @entity4


abstract: Naturally occurring @entity5 are rare in animals. The Japanese strains of spontaneously @entity3 @entity2 (SHR) are normotensive at birth but develop @entity3 , hyperglycaemia and hyperlipidaemia as they mature. The SHR strain is prone to develop @entity5 . A unique sub-strain of SHR has been developed in which some animals develop @entity1 concomitantly with their rising blood pressure, i.e. Obese/SHR. The Obese/SHR characteristically develop microscopic @entity5 which become detached at an early stage of formation, migrate to the bladder, and grow by concretion into huge, rounded calculi. The stone nidus starts as a subepithelial cyst-like focus containing @entity0 , @entity6 suspended on a delicate network of fibrils. THe nidi grow by concretion of an admixture of @entity4 and acidic protein in a lamellar arrangement. The disparate morphogenesis and anatomic location of @entity5 in Obese is opposed to @entity1 /SHR suggest that @entity7 formation may be governed by specific differences in genetic programming. The incidence of @entity5 parallels the severity and chronicity of the @entity3 in SHR, @entity1 and Obese/SHR, and the Cushingoid habitus in the Obese/SHR.

title: Kidney and bladder calculi in spontaneously XXXX @entity2 .

answer: @entity3


abstract: Naturally occurring @entity5 are rare in animals. The Japanese strains of spontaneously @entity3 @entity2 (SHR) are normotensive at birth but develop @entity3 , hyperglycaemia and hyperlipidaemia as they mature. The SHR strain is prone to develop @entity5 . A unique sub-strain of SHR has been developed in which some animals develop @entity1 concomitantly with their rising blood pressure, i.e. Obese/SHR. The Obese/SHR characteristically develop microscopic @entity5 which become detached at an early stage of formation, migrate to the bladder, and grow by concretion into huge, rounded calculi. The stone nidus starts as a subepithelial cyst-like focus containing @entity0 , @entity6 suspended on a delicate network of fibrils. THe nidi grow by concretion of an admixture of @entity4 and acidic protein in a lamellar arrangement. The disparate morphogenesis and anatomic location of @entity5 in Obese is opposed to @entity1 /SHR suggest that @entity7 formation may be governed by specific differences in genetic programming. The incidence of @entity5 parallels the severity and chronicity of the @entity3 in SHR, @entity1 and Obese/SHR, and the Cushingoid habitus in the Obese/SHR.

title: Kidney and bladder calculi in spontaneously @entity3 XXXX .

answer: @entity2


abstract: Platelet-associated IgG (PA IgG) of washed platelets of 20 normal controls and 45 @entity1 @entity0 was measured by radioimmunoassay and related to total platelet protein content. Mean values (+/- 2 SD) for 20 normals were 4.4 +/- 3.5 fg IgG per platelet (fg IgG/pl), 2.1 +/= 1.0 pg protein per platelet (pg protein/pl) and a ratio of IgG per g platelet protein of 2.1 +/- 1.8 mg IgG/g protein. @entity0 could be divided into two groups: Group I (31) with normal IgG/g protein ratios and either normal (16) or raised (15) fg IgG/pl, and Group II (14) with both fg IgG/pl and IgG/g protein raised. Of the 21 @entity0 with @entity1 ( @entity1 ), 13 were in Group I (seven with raised and six with normal fg IgG/pl), and eight in Group II. There was significant correlation between PA IgG (fg IgG/pl) and platelet protein for the entire Group I (r = 0.95, P less than 0.001). The @entity1 @entity0 in this group showed a similar correlation (r = 0.77, P less than 0.001), suggesting that raised PA IgG levels in Group I @entity0 may be a result of protein-rich platelets. 60-90% of PA IgG was found in the soluble fraction of lysates of platelets from both normals and @entity0 . Thus, it is either non-specifically associated with platelets or is antibody directed towards easily solubilized platelet antigens. Nine @entity1 @entity0 without @entity2 had raised PA IgG. These results question the assumption that raised PA IgG always indicates specific antiplatelet antibody.

title: Relationship of raised platelet IgG in XXXX to total platelet protein content.

answer: @entity1


abstract: UNASSIGNED: Current manufacturing of most bulk chemicals through petrochemical routes considerably contributes to common concerns over the depletion of fossil @entity0 sources and greenhouse gas emissions. Sustainable future production of commodities thus requires the shift to renewable feedstocks in combination with established or newly developed synthesis routes. In this study, the potential of @entity4 for autotrophic synthesis of the building block chemical @entity6 (2-HIBA) is evaluated. A novel biosynthetic pathway was implemented by heterologous expression of the 2-hydroxyisobutyryl-coenzyme A (2-HIB-CoA) mutase from Aquincola tertiaricarbonis L108, relying on a main intermediate of strain @entity4 's C4 overflow metabolism, @entity5 . The intention was to direct the latter to 2-HIBA instead or in addition to @entity1 ( @entity2 ). Autotrophic growth and 2-HIBA (respectively, @entity2 ) synthesis of wild-type and @entity2 -negative mutant strains were investigated producing maximum 2-HIBA titers of 3.2  g  L(-1) and maximum specific 2-HIBA synthesis rates (q 2-HIBA) of about 16 and 175   mol  g(-1)  h(-1), respectively. The obtained specific productivity was the highest reported to date for mutase-dependent 2-HIBA synthesis from heterotrophic and autotrophic substrates. Furthermore, expression of a G protein chaperone (MeaH) in addition to the 2-HIB-CoA mutase subunits yielded improved productivity. Analyzing the inhibition of growth and product synthesis due to substrate availability and product accumulation revealed a strong influence of 2-HIBA, when cells were cultivated at high titers. Nevertheless, the presented results imply that at the time the autotrophic synthesis route is superior to thus far established heterotrophic routes for production of 2-HIBA with @entity3 .

title: Exploiting mixtures of H2, CO 2, and O 2 for improved production of methacrylate precursor XXXX by engineered @entity3 strains.

answer: @entity6


abstract: UNASSIGNED: Current manufacturing of most bulk chemicals through petrochemical routes considerably contributes to common concerns over the depletion of fossil @entity0 sources and greenhouse gas emissions. Sustainable future production of commodities thus requires the shift to renewable feedstocks in combination with established or newly developed synthesis routes. In this study, the potential of @entity4 for autotrophic synthesis of the building block chemical @entity6 (2-HIBA) is evaluated. A novel biosynthetic pathway was implemented by heterologous expression of the 2-hydroxyisobutyryl-coenzyme A (2-HIB-CoA) mutase from Aquincola tertiaricarbonis L108, relying on a main intermediate of strain @entity4 's C4 overflow metabolism, @entity5 . The intention was to direct the latter to 2-HIBA instead or in addition to @entity1 ( @entity2 ). Autotrophic growth and 2-HIBA (respectively, @entity2 ) synthesis of wild-type and @entity2 -negative mutant strains were investigated producing maximum 2-HIBA titers of 3.2  g  L(-1) and maximum specific 2-HIBA synthesis rates (q 2-HIBA) of about 16 and 175   mol  g(-1)  h(-1), respectively. The obtained specific productivity was the highest reported to date for mutase-dependent 2-HIBA synthesis from heterotrophic and autotrophic substrates. Furthermore, expression of a G protein chaperone (MeaH) in addition to the 2-HIB-CoA mutase subunits yielded improved productivity. Analyzing the inhibition of growth and product synthesis due to substrate availability and product accumulation revealed a strong influence of 2-HIBA, when cells were cultivated at high titers. Nevertheless, the presented results imply that at the time the autotrophic synthesis route is superior to thus far established heterotrophic routes for production of 2-HIBA with @entity3 .

title: Exploiting mixtures of H2, CO 2, and O 2 for improved production of methacrylate precursor @entity6 by engineered XXXX strains.

answer: @entity3


abstract: There is renewed interest in the origin and makeup of @entity4 nodules (FMNs), long known to soil mineralogists as unusual secondary minerals. However, new evidence suggests that microorganisms play a significant role in the generation of FMNs. The biogenic origin of nodules has remained elusive because until recently, little has been known about the overall microbial community structure in their microbiota. To learn more about the microbial community and to determine the relative abundance, diversity, and composition of the microbial communities present in FMNs and their surrounding soil, we used pyrosequencing to investigate 16S rRNA genes obtained from vertical soil profiles of both paddy fields and sugarcane fields. Using pyrotaq 16S rRNA gene sequencing, we show that the microbial phylogenetic diversity of nodules was higher than those reported in previous studies of this biosphere, and we identified many previously unidentified microorganisms. Here, we show that the microbial community of these nodules is dominated by Burkholderiales, Rhodocyclales, Acidobacteriales, Desulfuromonales, and Clostridiales, and there were no statistically significant differences found when comparing the microbial community structures of FMNs obtained from vertical soil sequences. Although the microbial composition was markedly different between the surrounding soil and the FMNs, the microbes found within the FMNs were very similar to other FMNs from both field types examined here. In addition to their geochemical properties and the microbial community composition of FMNs, we found that the levels of @entity0 (Fe), @entity1 (Mn), and @entity2 greatly impact the microbial diversity among @entity3 communities. Our results indicate that the @entity3 microbial communities from different land-use types are very similar and suggest that natural selection of these microbes is based on the oligotrophic conditions and the high metal content. Researching FMNs in these two land-use patterns, which represent two different redox potentials, deepens our understanding of Fe-Mn biogeochemical cycling in these oligotrophic biospheres and suggests a biogenetical origin for these nodules.

title: Pyrosequencing revealed highly microbial phylogenetic diversity in XXXX nodules from farmland.

answer: @entity4


abstract: UNASSIGNED: It is essential that @entity0 with @entity1 receive educational information about their disease and its management, but there is dissatisfaction with the education received. The purposes of this evidence-based project were to examine the current knowledge level and disease management behaviors of @entity0 with @entity1 in an outpatient clinic and to measure the effectiveness of implementing a self-management protocol using the @entity1 Self-Management Scale (ESMS). Pender's health promotion model and Rogers' diffusion of innovation theory were used to guide the development and completion of this project. An evidence-based @entity1 self-management protocol was developed and implemented at an outpatient neurology clinic by an interprofessional clinic team that consisted of (a) evaluation of self-management behaviors (ESMS), (b) individual education using the ESMS and developed resources, (c) follow-up telephone call, and (d) measurement of outcomes of the self-management protocol ( @entity0 self-management [ESMS] and process). Twenty @entity0 participated in all or portions of the protocol. Scores on the ESMS increased from preimplementation to postimplementation of the protocol (t = -2.67). @entity2 management and information management were identified as the most difficult self-management areas. Recommended changes in protocol implementation include adding information about safety measures such as medical alert bracelets and driving to the educational packets. Follow-up telephone calls were discontinued because of difficulties reaching @entity0 . The results of this study suggest that the ESMS is an acceptable tool for evaluating @entity0 ' self-management behaviors. @entity1 self-management protocols need to include both verbal and written educational materials. Educating @entity0 with @entity1 about positive self-management behaviors may lead to better health outcomes.

title: Implementation of an XXXX Self-Management Protocol.

answer: @entity1


abstract: UNASSIGNED: Various chemotherapeutic agents used in @entity0 with @entity5 cause serious side effects, including myelosuppression and immunosuppression. Immunosuppression makes @entity0 more susceptible to @entity3 , resulting in an increased risk of @entity2 , including the development of severe @entity4 that may be life-threatening. It is necessary for dental staff to be familiar with an appropriate protocol in such cases and to share information about the chemotherapy with a hematologist. To verify the effectiveness of our dental intervention protocol, we conducted a prospective study on the incidence of complications for each myelosuppressive grade of chemotherapy in @entity0 with @entity5 . We compared the incidence of complications between treatment P ( @entity0 who finished all the dental treatments according to the protocol) and treatment Q ( @entity0 who did not) per grade (A, B, C, D) and incidence of systemic or oral findings. We also compared the incidence of oral complication related to the residual teeth between first chemo ( @entity0 who were undergoing chemotherapy for the first time) and prior chemo (not the first time). There were significant differences in inflammatory complications between treatment P and treatment Q. We found that both systemic and oral inflammatory complications increased with higher-grade myelosuppressive chemotherapy. Additionally, there was a significant difference between the incidence of oral complications related to the residual teeth between first chemo and prior chemo. Complete implementation of the dental intervention protocol was associated with fewer oral and systemic @entity2 and inflammatory complications in @entity0 with @entity5 undergoing chemotherapy. The incidence of @entity1 also increased with grade of chemotherapy. These results support the validity of our dental intervention protocol. We should pay close attention to the oral state of de novo @entity5 @entity0 .

title: Prospective Study of Dental Intervention for XXXX .

answer: @entity5


abstract: BACKGROUND: Little is known about the prevalence of @entity8 ( @entity8 ) across @entity6 subtypes. Given the important implications for @entity8 screening, we tested the association between @entity8 and @entity6 subtype in a population-based study. METHODS: Within the @entity5 in Corpus Christi Project, @entity6 @entity0 were offered @entity8 screening with the ApneaLink Plus (n  =  355). A neurologist assigned Trial of the @entity12 in Acute @entity4 Treatment subtype (with an additional category for nonlacunar @entity10 of unknown etiology) using hospital records. Unadjusted and adjusted (demographics, body mass index, National Institutes of Health @entity4 Scale, @entity1 , history of @entity4 /transient @entity3 attack) logistic and linear regression models were used to test the association between subtype and @entity8 or @entity7 - @entity8 index (AHI). RESULTS: Median age was 65%, and 55% were @entity0 ; 59% were Mexican American. Median time from @entity4 onset to @entity8 screen was 13  days (interquartile range [IQR] 6, 21). Overall, 215 (61%) had @entity8 (AHI >=  10). Median AHI was 13 (IQR 6, 27). Prevalence of @entity8 by subtype was cardioembolism, 66%; large-artery @entity9 , 57%; small-vessel occlusion, 68%; other determined, 50%; undetermined etiology, 58%; and nonlacunar @entity4 of unknown etiology, 63%. @entity6 subtype was not associated with @entity8 in unadjusted (P  =  .72) or adjusted models (P  =  .91) models. @entity6 subtype was not associated with AHI in unadjusted (P  =  .41) or adjusted models (P  =  .62). CONCLUSIONS: In this population-based @entity4 surveillance study, @entity6 subtype was not associated with the presence or severity of @entity8 . @entity2 @entity11 is likely to be present after @entity6 , and the subtype should not influence decisions about @entity8 screening.

title: @entity6 Subtype and Presence of XXXX Breathing: The BASIC Sleep Apnea Study.

answer: @entity2


abstract: BACKGROUND: Little is known about the prevalence of @entity8 ( @entity8 ) across @entity6 subtypes. Given the important implications for @entity8 screening, we tested the association between @entity8 and @entity6 subtype in a population-based study. METHODS: Within the @entity5 in Corpus Christi Project, @entity6 @entity0 were offered @entity8 screening with the ApneaLink Plus (n  =  355). A neurologist assigned Trial of the @entity12 in Acute @entity4 Treatment subtype (with an additional category for nonlacunar @entity10 of unknown etiology) using hospital records. Unadjusted and adjusted (demographics, body mass index, National Institutes of Health @entity4 Scale, @entity1 , history of @entity4 /transient @entity3 attack) logistic and linear regression models were used to test the association between subtype and @entity8 or @entity7 - @entity8 index (AHI). RESULTS: Median age was 65%, and 55% were @entity0 ; 59% were Mexican American. Median time from @entity4 onset to @entity8 screen was 13  days (interquartile range [IQR] 6, 21). Overall, 215 (61%) had @entity8 (AHI >=  10). Median AHI was 13 (IQR 6, 27). Prevalence of @entity8 by subtype was cardioembolism, 66%; large-artery @entity9 , 57%; small-vessel occlusion, 68%; other determined, 50%; undetermined etiology, 58%; and nonlacunar @entity4 of unknown etiology, 63%. @entity6 subtype was not associated with @entity8 in unadjusted (P  =  .72) or adjusted models (P  =  .91) models. @entity6 subtype was not associated with AHI in unadjusted (P  =  .41) or adjusted models (P  =  .62). CONCLUSIONS: In this population-based @entity4 surveillance study, @entity6 subtype was not associated with the presence or severity of @entity8 . @entity2 @entity11 is likely to be present after @entity6 , and the subtype should not influence decisions about @entity8 screening.

title: XXXX Subtype and Presence of @entity2 Breathing: The BASIC Sleep Apnea Study.

answer: @entity6


abstract: Haemodynamic investigations were performed in 40 @entity0 with acute @entity2 before and after intravenous application of 6 mg @entity3 . Cardiac index was significantly decreased caused by reduction of cardiac frequency and @entity1 volume. Pulmonary capillary pressure increased significantly. As a consequence pulmonary and peripheral vascular resistance increased. Arterial blood pressure remained largely unaffected. @entity3 showed a haemodynamically beneficial decrease of left @entity1 without signs of negative cardiodepression at a cardiac index of more than 3.0 l/min . m2. At a cardiac index of less than 3.0 l/min . m2 a haemodynamically detrimental lowering of cardiac index to ranges of insufficiency of 2.0 l/min . m2 on average occurred. Thus cardiac index is an important factor for the decision of use of beta-blocking agents in acute @entity2 . Indiscriminate use of beta-blocking substances should not be accepted.

title: [Risks of treatment with beta-blocking agents in acute XXXX (author's transl)].

answer: @entity2


abstract: INTRODUCTION: Excitation of @entity2 -mediated (Ach) transmission (especially if irreversible) may pose life-threatening adverse events by increasing neuronal network activity. Unfortunately, adequate detection of this liability during early drug development is hampered, because published ex vivo electrophysiological models are very insensitive to this regard. For example, @entity5 , which reversibly inhibits @entity7 ( @entity7 ) in the double digit nM range, affects electrically evoked potentials in hippocampal slices only at >= 10 M. Here, a significantly more sensitive method for detecting @entity4 -mediated alternations is presented by analyzing spontaneous neuronal network activity in hippocampal slices. METHODS: The microelectrode array (MEA) technique with an 8*8 electrode grid was applied to analyze evoked and spontaneous extracellular field recordings in parallel from acute @entity0 hippocampal slices. For evoked potentials, the Schaffer collateral @entity10 pathway was electrically stimulated and the resulting field potential analyzed at the @entity3 pyramidal layer. Spontaneous spike activity was detected as negative inflections from the 100Hz high pass filtered signal. Spike frequency was analyzed within the whole @entity3 region. RESULTS: Modification of Ach-mediated neuronal transmission via @entity8 , @entity5 , or @entity9 ( @entity9 ) does not induce any effects on evoked field potentials at physiologically relevant concentrations. Similar to previous reports, subtle effects were detectable at very high concentrations. By contrast, spontaneous spike frequency was already increased within the expected concentration range. @entity5 -induced effects can also be reversed by @entity6 and washout. On the contrary, effects by the irreversible @entity7 -blocker DFP could not be washed out. DISCUSSION: Compared to evoked field potentials, spontaneous spike activity in the hippocampal @entity3 region appears to be a significantly more sensitive parameter for functional electrophysiological analysis of drug induced Ach-mediated effects. This finding may supplement existing models for detection and prediction of drug-related adverse effects like @entity1 liability already during early development stages.

title: Analysis of spontaneous hippocampal activity allows sensitive detection of XXXX -mediated effects.

answer: @entity2


abstract: In an analysis of 12 @entity0 fibroblast cell lines by two-dimensional electrophoresis, one cell line (1493) was found to contain a major protein variant (Cytosk: 12; for the convention used in spot numbering, see Anderson, N. L. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 2407-2411) not present in any of the other 11 cell lines. Biochemical characterization of the variant protein included determination of its subcellular location, partial @entity3 composition, behavior on @entity7 ( @entity1 ) versus @entity1 / @entity4 gels, and partial proteolytic digestion patterns. All of these methods showed that Cytosk:12 is related to Cytosk:11. Both proteins are located in the cytoskeleton, contain little @entity2 or @entity5 and no detectable @entity6 , shift together to a higher apparent molecular weight when electrophoresed in the presence of @entity1 and 8 M @entity4 versus @entity1 alone, and have identical products after partial proteolysis according to Cleveland et al. (Cleveland, D. W., Fischer, S. G., Kirschner, M. W., and Laemmli, U. K. (1977) J. Biol. Chem. 252, 1102-1106). Preparation of nonmuscle tropomyosin resulted in the partial purification of both Cytosk:11 and :12. The data suggest that Cytosk:11 is fibroblast nonmuscle tropomyosin and that Cytosk:12 in cell line 1493 is a charge variant of that protein.

title: A variant of XXXX nonmuscle tropomyosin found in fibroblasts by using two-dimensional electrophoresis.

answer: @entity0


abstract: BACKGROUND: This prospective study was undertaken to assess @entity3 , resectability, and survival in @entity5 @entity0 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity2 , @entity7 , and @entity4 (GTX) and @entity2 and @entity4 (GX)/radiation therapy ( @entity6 ). METHODS: All @entity0 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity0 (mean age, 64 years; range, 44-83 years)-34 @entity0 deemed unresectable because of arterial involvement and 11 @entity0 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity6 after chemotherapy. RESULTS: The GTX and GX/ @entity6 treatments were tolerated with the expected drug-related @entity3 . There were no bowel perforations, cases of @entity5 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity0 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity0 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity0 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity0 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity6 is an effective neoadjuvant regimen that can be safely administered to @entity0 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity1 2014.    2014 American @entity1 Society.

title: Neoadjuvant @entity2 , @entity7 , and @entity4 followed by @entity2 and @entity4 @entity6 and surgery in locally advanced, unresectable XXXX .

answer: @entity5


abstract: BACKGROUND: This prospective study was undertaken to assess @entity3 , resectability, and survival in @entity5 @entity0 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity2 , @entity7 , and @entity4 (GTX) and @entity2 and @entity4 (GX)/radiation therapy ( @entity6 ). METHODS: All @entity0 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity0 (mean age, 64 years; range, 44-83 years)-34 @entity0 deemed unresectable because of arterial involvement and 11 @entity0 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity6 after chemotherapy. RESULTS: The GTX and GX/ @entity6 treatments were tolerated with the expected drug-related @entity3 . There were no bowel perforations, cases of @entity5 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity0 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity0 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity0 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity0 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity6 is an effective neoadjuvant regimen that can be safely administered to @entity0 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity1 2014.    2014 American @entity1 Society.

title: Neoadjuvant XXXX , @entity7 , and @entity4 followed by @entity2 and @entity4 @entity6 and surgery in locally advanced, unresectable @entity5 .

answer: @entity2


abstract: BACKGROUND: This prospective study was undertaken to assess @entity3 , resectability, and survival in @entity5 @entity0 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity2 , @entity7 , and @entity4 (GTX) and @entity2 and @entity4 (GX)/radiation therapy ( @entity6 ). METHODS: All @entity0 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity0 (mean age, 64 years; range, 44-83 years)-34 @entity0 deemed unresectable because of arterial involvement and 11 @entity0 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity6 after chemotherapy. RESULTS: The GTX and GX/ @entity6 treatments were tolerated with the expected drug-related @entity3 . There were no bowel perforations, cases of @entity5 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity0 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity0 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity0 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity0 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity6 is an effective neoadjuvant regimen that can be safely administered to @entity0 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity1 2014.    2014 American @entity1 Society.

title: Neoadjuvant @entity2 , @entity7 , and @entity4 followed by XXXX and @entity4 @entity6 and surgery in locally advanced, unresectable @entity5 .

answer: @entity2


abstract: BACKGROUND: This prospective study was undertaken to assess @entity3 , resectability, and survival in @entity5 @entity0 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity2 , @entity7 , and @entity4 (GTX) and @entity2 and @entity4 (GX)/radiation therapy ( @entity6 ). METHODS: All @entity0 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity0 (mean age, 64 years; range, 44-83 years)-34 @entity0 deemed unresectable because of arterial involvement and 11 @entity0 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity6 after chemotherapy. RESULTS: The GTX and GX/ @entity6 treatments were tolerated with the expected drug-related @entity3 . There were no bowel perforations, cases of @entity5 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity0 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity0 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity0 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity0 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity6 is an effective neoadjuvant regimen that can be safely administered to @entity0 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity1 2014.    2014 American @entity1 Society.

title: Neoadjuvant @entity2 , @entity7 , and XXXX followed by @entity2 and @entity4 @entity6 and surgery in locally advanced, unresectable @entity5 .

answer: @entity4


abstract: BACKGROUND: This prospective study was undertaken to assess @entity3 , resectability, and survival in @entity5 @entity0 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity2 , @entity7 , and @entity4 (GTX) and @entity2 and @entity4 (GX)/radiation therapy ( @entity6 ). METHODS: All @entity0 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity0 (mean age, 64 years; range, 44-83 years)-34 @entity0 deemed unresectable because of arterial involvement and 11 @entity0 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity6 after chemotherapy. RESULTS: The GTX and GX/ @entity6 treatments were tolerated with the expected drug-related @entity3 . There were no bowel perforations, cases of @entity5 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity0 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity0 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity0 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity0 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity6 is an effective neoadjuvant regimen that can be safely administered to @entity0 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity1 2014.    2014 American @entity1 Society.

title: Neoadjuvant @entity2 , @entity7 , and @entity4 followed by @entity2 and XXXX @entity6 and surgery in locally advanced, unresectable @entity5 .

answer: @entity4


abstract: BACKGROUND: This prospective study was undertaken to assess @entity3 , resectability, and survival in @entity5 @entity0 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity2 , @entity7 , and @entity4 (GTX) and @entity2 and @entity4 (GX)/radiation therapy ( @entity6 ). METHODS: All @entity0 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity0 (mean age, 64 years; range, 44-83 years)-34 @entity0 deemed unresectable because of arterial involvement and 11 @entity0 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity6 after chemotherapy. RESULTS: The GTX and GX/ @entity6 treatments were tolerated with the expected drug-related @entity3 . There were no bowel perforations, cases of @entity5 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity0 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity0 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity0 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity0 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity6 is an effective neoadjuvant regimen that can be safely administered to @entity0 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity1 2014.    2014 American @entity1 Society.

title: Neoadjuvant @entity2 , XXXX , and @entity4 followed by @entity2 and @entity4 @entity6 and surgery in locally advanced, unresectable @entity5 .

answer: @entity7


abstract: BACKGROUND: This prospective study was undertaken to assess @entity3 , resectability, and survival in @entity5 @entity0 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity2 , @entity7 , and @entity4 (GTX) and @entity2 and @entity4 (GX)/radiation therapy ( @entity6 ). METHODS: All @entity0 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity0 (mean age, 64 years; range, 44-83 years)-34 @entity0 deemed unresectable because of arterial involvement and 11 @entity0 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity6 after chemotherapy. RESULTS: The GTX and GX/ @entity6 treatments were tolerated with the expected drug-related @entity3 . There were no bowel perforations, cases of @entity5 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity0 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity0 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity0 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity0 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity6 is an effective neoadjuvant regimen that can be safely administered to @entity0 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity1 2014.    2014 American @entity1 Society.

title: Neoadjuvant @entity2 , @entity7 , and @entity4 followed by @entity2 and @entity4 XXXX and surgery in locally advanced, unresectable @entity5 .

answer: @entity6


abstract: Phosphate chemical conversion (PCC) technology has been investigated for improving the surface performance of metallic implants in the biomedical field over the last decade. The metallic materials, such as @entity6 and its alloys, @entity4 , pure @entity0 and stainless steel are widely used as orthopedic devices for immobilization of @entity1 in clinic. They were previously studied as metal substrates for @entity7 aiming to modify their biocompatibility and osteoconductivity. @entity2 , @entity3 and zinc-calcium PCC coatings are frequently utilized considering their nature and the end-use. Although @entity7 has been confirmed to potentially improve the bio-performance of metallic implants in vitro and in vivo by many researchers, there are no unified standards or regulations to give quantitative appraisal of its quality and property. As such, an overview of several main @entity5 phases together with their properties and behaviors in vitro and in vivo was conducted. The mechanism of phosphating was also briefly discussed. Critical qualities of @entity7 used for biomedical application including corrosion resistance, wettability and bonding strength were analyzed separately. Biological response including in vitro cell investigations and in vivo tissue response were discussed in terms of the cytocompatibility and bioactivity of @entity7 . Further investigations are proposed to develop appropriate performance evaluation measurements by combining conventional technologies and biomedical procedures.

title: XXXX chemical conversion coatings on metallic substrates for biomedical application: A review.

answer: @entity5


abstract: Objective Chro @entity4 common, intractable and often recurrent, but care tends to be wound focused, potentially overlooking the significant impact the condition has on pati @entity0 ves. A systematic review was undertaken to explore the factors that impact on the quality of life of pati @entity0 h chronic venous leg ulce @entity3  Method Eligible articles published between 1990 and 2013 were identified via electronic searches of research databases (MEDLINE, CINAHL, BNI, EMBASE, PsycINFO, AMED and HMIC, Cochrane Collaboration database and Google Scholar).     Results There were 23 studies (11 qualitative and 12 quantitative) that met the inclusion criteria. There were then the subject of a full review. The qualitative studies were collapsed into four core themes: physical, psyc @entity5 the nurse-pati @entity0 ationship. The quantitative studies were grouped according to the tool applied. The review demonstrated that chronic veno @entity4 act negatively upon all areas of daily living. Pain @entity1 udate, odour and the impact on mobility were daily challenges. The ability to engage with everyday functioning was restricted either owing to the ulce @entity3 e dressing or to a self-imposed isolation in response to the impact of symptoms. Depr @entity2 low mood were common and yet, despite this, some studies reported that part @entity0 ained hopeful.     Conclusion Studies suggest that chronic venous leg ulce @entity3 atively affects the quality of life of the pati @entity0 that such issues receive inadequate attention during current consultations. If such negative implications are to be effectively addressed, key issues need to be considered during every consultation.     Declaration of interest This study was funded by West Midlands Strategic Health Authority. The authors have no conflicts of interest to declare.

title: The impact of chronic XXXX : a systematic review.

answer: @entity4


abstract: PURPOSE: Initial successful surgical treatment of @entity3 is crucial to reach long-term remission. @entity7  (ICG) videoangiography (VA) is well established in vascular neurosurgery nowadays and several reports described ICG application in @entity5 surgery. We designed this study to evaluate the feasibility of intravenous application of ICG and visualisation of a @entity8 via the fluorescence mode of the operation microscope. METHODS: 22 @entity0 with @entity3 were treated with transsphenoidal microsurgery and were included in this study. Intraoperatively 25  mg ICG was administered intravenously and visualized via the fluorescence mode of the operation microscope (Pentero/Zeiss). RESULTS: 22 @entity0 qualified for transsphenoidal surgery presenting with different clinical symptoms (13 @entity0 with @entity6 , 6 with M. Cushing and 3 with other symptoms like @entity1 or @entity4 ) and identification of a @entity8 (21 of 22 @entity0 ) in preoperative MR-imaging (mean diameter: 9  mm; SD 3.6; 6 macroadenomas, 15 microadenomas, 1 MR-negative). In all 22 @entity0 ICG  VA was performed during surgery. No technical failures or adverse events after drug administration occurred. Visualization was optimal approximately 2.4  min after intravenous application. In all @entity0 the @entity2 could be detected via two different types of visualization: direct visualization by fluorophore emission versus indirect detection of the @entity2 by a lower ICG  fluorescence compared to the surrounding tissue. CONCLUSION: Our data show that intraoperative ICG VA  can be a useful and easily applicable additional diagnostic tool for visualization of pituitary lesions using the microscopic approach.

title: Intraoperative indocyanine green videoangiography for identification of XXXX using a microscopic transsphenoidal approach.

answer: @entity3


abstract: PURPOSE: In @entity0 , @entity4 ( @entity4 ) is mostly caused by intrinsic factors (IUPJO); extrinsic @entity4 are rare and often due to crossing vessels (CVs). METHODS: We retrospectively reviewed all data of @entity0 with @entity4 that underwent surgery in our institution from 2004 to 2011. Analyses included age at surgery, gender, preoperative and postoperative results of ultrasound and renal scans [differential renal function (DRF); signs of obstruction], and pathology reports. Available histological specimens of cases with CV were compared to a random selection of intrinsic cases in a blinded fashion. After additional Masson's trichrome staining, the specimens were scored for @entity2 , muscular @entity3 , and @entity1 . RESULTS: Out of 139 @entity0 with @entity4 , 39 cases were associated with CV. Median age at surgery was 68  months (range 2-194) in the CV group and 11.5  months (range 0-188) in IUPJO group. Laparoscopic dismembered pyeloplasty (LDMP) was carried out in 134 and open DMP in five @entity0 . Preoperative ultrasound identified 28/39 cases with CV. DRF below 40  % was more frequently seen in CV @entity0 (p  =  0.020). Histological analyses revealed no differences between the CV and IUPJO specimens in total. CV @entity0 with higher grades of muscular @entity3 had lower preoperative DRF, compared to those with higher preoperative DRF (p  =  0.026). Functional recovery after (L)DMP was excellent in both groups. CONCLUSION: We could not find any significant histological differences between CV and IUPJO in @entity0 . To obtain excellent functional recovery, surgical procedures with a definite correction of the UPJ should be preferred in paediatric @entity0 with CV.

title: Differences between intrinsic and extrinsic XXXX related to crossing vessels: histology and functional analyses.

answer: @entity4


abstract: (R,R')-4-methoxy-1-naphthylfenoterol (MNF) inhibits cancer cell proliferation in vitro through cell-type specific modulation of b2-adrenergic receptor and/or cannabinoid receptor function. Here, we report an investigation into antitumor activity of MNF in @entity2 @entity3 cells. The potent antiproliferative action of MNF in these cells (IC50 of    1 nmol/L) was refractory to pharmacological inhibition of b2-adrenergic receptor while a synthetic inverse agonist of cannabinoid receptor 1 significantly blocked MNF activity. The antitumor activity of MNF was then assessed in a C6 @entity4 xenograft model in @entity1 . Three days after subcutaneous implantation of C6 cells into the lower flank of @entity1 , these animals were subjected to i.p. injections of saline or MNF (2 mg/kg) for 19 days and @entity0 volumes were measured over the course of the experiment. Gene expression analysis, quantitative RT-PCR and immunoblot assays were performed on the @entity0 after treatment. Significant @entity0 volumes was observed in @entity1 receiving MNF when compared with the saline-treated group. We identified clusters in expression of genes involved in cellular proliferation, as well as molecular markers for @entity4 that were significantly downregulated in @entity0 of MNF-treated @entity1 as compared to saline-injected controls. The efficacy of MNF against @entity3 cell proliferation in vivo and in vitro was accompanied by marked reduction in the expression of cell cycle regulator proteins. This study is the first demonstration of MNF-dependent chemoprevention of a @entity4 xenograft model and may offer a potential mechanism for its anticancer action in vivo.

title: Antitumor activity of (R,R')-4-methoxy-1-naphthylfenoterol in a XXXX @entity3 xenograft model in the @entity1 .

answer: @entity2


abstract: (R,R')-4-methoxy-1-naphthylfenoterol (MNF) inhibits cancer cell proliferation in vitro through cell-type specific modulation of b2-adrenergic receptor and/or cannabinoid receptor function. Here, we report an investigation into antitumor activity of MNF in @entity2 @entity3 cells. The potent antiproliferative action of MNF in these cells (IC50 of    1 nmol/L) was refractory to pharmacological inhibition of b2-adrenergic receptor while a synthetic inverse agonist of cannabinoid receptor 1 significantly blocked MNF activity. The antitumor activity of MNF was then assessed in a C6 @entity4 xenograft model in @entity1 . Three days after subcutaneous implantation of C6 cells into the lower flank of @entity1 , these animals were subjected to i.p. injections of saline or MNF (2 mg/kg) for 19 days and @entity0 volumes were measured over the course of the experiment. Gene expression analysis, quantitative RT-PCR and immunoblot assays were performed on the @entity0 after treatment. Significant @entity0 volumes was observed in @entity1 receiving MNF when compared with the saline-treated group. We identified clusters in expression of genes involved in cellular proliferation, as well as molecular markers for @entity4 that were significantly downregulated in @entity0 of MNF-treated @entity1 as compared to saline-injected controls. The efficacy of MNF against @entity3 cell proliferation in vivo and in vitro was accompanied by marked reduction in the expression of cell cycle regulator proteins. This study is the first demonstration of MNF-dependent chemoprevention of a @entity4 xenograft model and may offer a potential mechanism for its anticancer action in vivo.

title: Antitumor activity of (R,R')-4-methoxy-1-naphthylfenoterol in a @entity2 XXXX xenograft model in the @entity1 .

answer: @entity3


abstract: (R,R')-4-methoxy-1-naphthylfenoterol (MNF) inhibits cancer cell proliferation in vitro through cell-type specific modulation of b2-adrenergic receptor and/or cannabinoid receptor function. Here, we report an investigation into antitumor activity of MNF in @entity2 @entity3 cells. The potent antiproliferative action of MNF in these cells (IC50 of    1 nmol/L) was refractory to pharmacological inhibition of b2-adrenergic receptor while a synthetic inverse agonist of cannabinoid receptor 1 significantly blocked MNF activity. The antitumor activity of MNF was then assessed in a C6 @entity4 xenograft model in @entity1 . Three days after subcutaneous implantation of C6 cells into the lower flank of @entity1 , these animals were subjected to i.p. injections of saline or MNF (2 mg/kg) for 19 days and @entity0 volumes were measured over the course of the experiment. Gene expression analysis, quantitative RT-PCR and immunoblot assays were performed on the @entity0 after treatment. Significant @entity0 volumes was observed in @entity1 receiving MNF when compared with the saline-treated group. We identified clusters in expression of genes involved in cellular proliferation, as well as molecular markers for @entity4 that were significantly downregulated in @entity0 of MNF-treated @entity1 as compared to saline-injected controls. The efficacy of MNF against @entity3 cell proliferation in vivo and in vitro was accompanied by marked reduction in the expression of cell cycle regulator proteins. This study is the first demonstration of MNF-dependent chemoprevention of a @entity4 xenograft model and may offer a potential mechanism for its anticancer action in vivo.

title: Antitumor activity of (R,R')-4-methoxy-1-naphthylfenoterol in a @entity2 @entity3 xenograft model in the XXXX .

answer: @entity1


abstract: We report two cases of @entity0 with necrotising @entity10 who presented initially with @entity3 and swelling on a background of respiratory complaints. @entity0 1, a previously well 38-year-old female, underwent various investigations in the @entity6 department for excessive @entity3 and a @entity8 . @entity0 2, a 61-year-old female with a background of @entity5 and @entity2 , presented to accident and @entity6 feeling generally unwell and was treated for presumed @entity7 . Both deteriorated rapidly and were referred to the plastic surgery team with soft tissue @entity1 , @entity4 and toxaemia. Large areas of necrotic muscle and skin were debrided, which grew group A streptococci, @entity9 . @entity0 1 had a high above knee amputation of the left leg with extensive debridement of the right. Despite aggressive surgical intervention and microbiological input with intensive care support, @entity0 2 died. These two cases highlight the importance of early diagnosis and prompt surgical and pharmacological intervention in managing this life-threatening disease. @entity3 is the primary symptom with skin changes being a late and subtle sign in a septic @entity0 . The Laboratory Risk Indicator for @entity11 (LRINEC) may be of use if there is concern to aid diagnosis of this life-threatening disease.

title: XXXX , the deadly impersonator.

answer: @entity10