abstract: OBJECTIVE: To evaluate the clinical and radiographic characteristics of @entity5 @entity7 of the petrous apex, as well as the outcomes of operative and conservative management. STUDY DESIGN: Retrospective chart review. SETTING: Two independent tertiary academic referral centers. @entity0 : Adult and pediatric @entity0 with @entity5 @entity7 of the petrous apex were identified from the experience of two separate centers. @entity0 were included after radiographic diagnosis and clinical evaluation. All @entity0 with less than 6 months of follow-up and those with iatrogenic postoperative @entity5 @entity7 were excluded. INTERVENTION: Demographic information, presenting symptoms, imaging characteristics, treatment strategies, and outcomes were recorded. MAIN OUTCOME MEASURES: @entity0 were evaluated on the basis of symptom and radiographic evolution during time, with or without operative intervention. RESULTS: Ninety petrous apex @entity5 @entity7 were analyzed (57.8% females, 55.6% right-sided). The average age at presentation was 43.1 years (median 42.0, range 8.0-77.0 years). The most common presenting symptom was @entity1 (56.7%), and the average lesion size in the greatest dimension was 2.1cm (median 1.7, range 0.7-5.0cm). During a mean follow-up of 46.0 months, no cases of spontaneous @entity6 or @entity4 occurred. Twenty-three @entity0 (25.6%) ultimately underwent surgical management, most commonly for intractable @entity1 , and only 47.8% of these @entity0 experienced durable symptom improvement by their last postoperative follow-up. CONCLUSION: Many @entity5 @entity7 of the petrous apex remain stable during time and can be safely managed with primary observation. Surgery should be reserved for lesions that are causing, or threatening, @entity2 because of mass effect or erosion of critical structures such as the otic capsule. @entity3 associated with @entity5 @entity7 may improve after operative management; however, symptoms such as @entity1 and @entity8 are less likely to benefit from surgery. As a general guideline, in the presence of a radiologically stable @entity5 @entity7 in the petrous apex, alternative etiologies for @entity1 and @entity8 should be considered and treated before offering surgical intervention.

title: The Natural History and Management of Petrous Apex XXXX @entity7 .

answer: @entity5


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Daouri, a combination of several plants, is an old African Traditional Medicine based on ancestral knowledge transmitted from generation to generation and is used by the Kotokoli Community in Togo. The combination of several plants may potentiate or attenuate the @entity3 of individual plants. The present investigation aims to study the composition and potential @entity3 of Daouri used in @entity0 in the Kotokoli community. MATERIALS AND METHODS: Surveys were performed using a semi-structured questionnaire to determine the composition of Daouri. On the basis of these data collected, Standard Daouri was formulated, and its aqueous extract was orally administered at 300, 600 and 1200mg/kg to @entity1 for 28 days. On the 29th day, the @entity1 were sacrificed and their serum were analysed to evaluate @entity2 . RESULTS: Four categories of Daouri were collected. The plant combinations used in each Daouri formulation varied according to the pathological conditions, including the age of the @entity0 and the availability of each plant. The most plants cited in the four Daouri were Khaya senegalensis (Desv.) A. Juss, Odina acida (A. Rich.) Oliv.,Lophira lanceolata Tiegh, Paullinia pinnata L. and Pteleopsis suberosa Engl. _ Diels. Although there was an increase in the alkaline phosphatase concentration, different doses of the aqueous extract of Standard Daouri were not toxic after 28 days of administration. In addition, the concentrations of @entity4 transaminase, @entity5 and @entity6 were not different between the Daouri-treated and control groups. CONCLUSION: Daouri is plant combination used in @entity0 in the Kotokoli community as a part of African Traditional Medicine. Standard Daouri is not toxic in @entity1 .

title: Toxicological screening of Daouri, a polyherbal formulation used in XXXX in the Central Region of Togo.

answer: @entity0


abstract: AIM: To test the efficacy of lay open (deroofing, not excision) with curettage under local anesthesia (LOCULA) for @entity2 as an outpatient procedure. METHODS: LOCULA procedure was done for all types of @entity1 . The primary outcome measure was cure rate. The secondary outcome measures were hospital stay, operating time, return to work, healing time and complication rate. RESULTS: Thirty-three (M/ @entity3 , mean age-23.4    5.8 years) consecutive @entity0 were operated and followed for 24 mo (6-46 mo). Eleven were @entity2 and 22 were chronic @entity1 . Six had recurrent disease. Operating time and the hospital stay was 22.3    5.6 min and 63.8    22.3 min respectively. The @entity0 could resume normal work in 4.3    3.2 d and the healing time was 42.9    8.1 d. Thirty (93.8%) @entity0 had complete resolution of the disease and two (6.2%) had a recurrence. Both the recurrences happened in @entity0 who had complete healing but ignored the prescribed recommendations. One out of these got cured after getting operated again with the same procedure. Thus the overall success rate of this procedure was 96.9%. CONCLUSION: Lay open (deroofing) with curettage procedure under local anesthesia is an effective procedure to treat both simple and complicated @entity2 . It is a simple procedure, has a high cure rate (up to 97%), doesn't require admission and is associated with minimal morbidity and scarring. Considering the distinct advantages, this procedure has the potential to become the first line procedure for treating @entity1 .

title: Laying open (deroofing) and curettage under local anesthesia for XXXX : An outpatient procedure.

answer: @entity1


abstract: OBJECTIVE: To compare the efficacy and tolerance of adjuvant chemotherapy and radiotherapy delivered in sequential (chemotherapy followed by radiation) versus "sandwich" fashion (chemotherapy, interval radiation, and remaining chemotherapy) after surgery in @entity0 with FIGO stage III uterine @entity7 . METHODS: From 2004 to 2011, we identified 51 @entity0 treated at our institution fitting the above criteria. All @entity0 received surgical staging followed by adjuvant chemoradiation (external-beam radiation therapy (EBRT) with or without @entity4 ( @entity4 ) vaginal brachytherapy (VB)). Of these, 73% and 27% of @entity0 received their adjuvant therapy in sequential and sandwich fashion, respectively. RESULTS: There were no significant differences in clinical or pathologic factors between @entity0 treated with either regimen. Thirty-nine (76%) @entity0 had stage IIIC disease. The majority of @entity0 received 6cycles of @entity5 with @entity6 or @entity3 . Median EBRT dose was 45Gy and 54% of @entity0 received @entity4 VB boost (median dose 21Gy). There were no significant differences in the estimated 5-year overall survival, local progression-free survival, and distant metastasis-free survival between the sequential and sandwich groups: 87% vs. 77% (p=0.37), 89% vs. 100% (p=0.21), and 78% vs. 85% (p=0.79), respectively. No grade 3-4 genitourinary or gastrointestinal @entity2 were reported in either group. There was a trend towards higher incidence of grade 3-4 hematologic @entity2 in the sandwich group. CONCLUSION: Adjuvant chemoradiation for FIGO stage III endometrioid uterine @entity1 given in either sequential or sandwich fashion appears to offer equally excellent early clinical outcomes and acceptably low @entity2 .

title: Sequential versus "sandwich" sequencing of adjuvant chemoradiation for the treatment of stage III uterine XXXX .

answer: @entity7


abstract: UNASSIGNED: A @entity3 ( @entity3 ) taskforce recently proposed diagnostic criteria for @entity2 with features of mild @entity1 ( @entity4 ). This study first examined the prevalence and nature of @entity4 in a non-demented cohort using the @entity3 criteria. Using the generic Monte Carlo simulation method developed by Crawford and colleagues (2007), this study then estimated the base rate of the representative population who would demonstrate @entity4 due to chance alone. A total of 104 @entity0 with idiopathic @entity4 underwent extensive motor and neuropsychological testing at baseline and 2 years later. The Unified @entity2 Rating Scale (UPDRS) was used to assess motor symptoms of @entity4 and a range of established neuropsychological tests was used to assess @entity4 in accord with @entity3 criteria. In accord with @entity3 criteria, 38% of this cohort demonstrated @entity4 at baseline and 48% at follow-up. Of the 36 @entity0 in the multiple-domain @entity4 subtype at time-1, 9 (25%) demonstrated no @entity4 at follow up. Analysis revealed that approximately 13% of the representative population would demonstrate abnormally low scores for 2 of the 9 tests used, thereby meeting @entity3 criteria for @entity4 . Clinicians and researchers need to approach a single diagnosis (i.e., based on one assessment) of @entity4 with considerable caution. (JINS, 2015, 21, 1-9).

title: Retrospective Assessment of XXXX Criteria for Mild @entity1 in @entity2 .

answer: @entity3


abstract: UNASSIGNED: A @entity3 ( @entity3 ) taskforce recently proposed diagnostic criteria for @entity2 with features of mild @entity1 ( @entity4 ). This study first examined the prevalence and nature of @entity4 in a non-demented cohort using the @entity3 criteria. Using the generic Monte Carlo simulation method developed by Crawford and colleagues (2007), this study then estimated the base rate of the representative population who would demonstrate @entity4 due to chance alone. A total of 104 @entity0 with idiopathic @entity4 underwent extensive motor and neuropsychological testing at baseline and 2 years later. The Unified @entity2 Rating Scale (UPDRS) was used to assess motor symptoms of @entity4 and a range of established neuropsychological tests was used to assess @entity4 in accord with @entity3 criteria. In accord with @entity3 criteria, 38% of this cohort demonstrated @entity4 at baseline and 48% at follow-up. Of the 36 @entity0 in the multiple-domain @entity4 subtype at time-1, 9 (25%) demonstrated no @entity4 at follow up. Analysis revealed that approximately 13% of the representative population would demonstrate abnormally low scores for 2 of the 9 tests used, thereby meeting @entity3 criteria for @entity4 . Clinicians and researchers need to approach a single diagnosis (i.e., based on one assessment) of @entity4 with considerable caution. (JINS, 2015, 21, 1-9).

title: Retrospective Assessment of @entity3 Criteria for Mild @entity1 in XXXX .

answer: @entity2


abstract: UNASSIGNED: A @entity3 ( @entity3 ) taskforce recently proposed diagnostic criteria for @entity2 with features of mild @entity1 ( @entity4 ). This study first examined the prevalence and nature of @entity4 in a non-demented cohort using the @entity3 criteria. Using the generic Monte Carlo simulation method developed by Crawford and colleagues (2007), this study then estimated the base rate of the representative population who would demonstrate @entity4 due to chance alone. A total of 104 @entity0 with idiopathic @entity4 underwent extensive motor and neuropsychological testing at baseline and 2 years later. The Unified @entity2 Rating Scale (UPDRS) was used to assess motor symptoms of @entity4 and a range of established neuropsychological tests was used to assess @entity4 in accord with @entity3 criteria. In accord with @entity3 criteria, 38% of this cohort demonstrated @entity4 at baseline and 48% at follow-up. Of the 36 @entity0 in the multiple-domain @entity4 subtype at time-1, 9 (25%) demonstrated no @entity4 at follow up. Analysis revealed that approximately 13% of the representative population would demonstrate abnormally low scores for 2 of the 9 tests used, thereby meeting @entity3 criteria for @entity4 . Clinicians and researchers need to approach a single diagnosis (i.e., based on one assessment) of @entity4 with considerable caution. (JINS, 2015, 21, 1-9).

title: Retrospective Assessment of @entity3 Criteria for Mild XXXX in @entity2 .

answer: @entity1


abstract: A survey of medical examinations has been made on occupational @entity7 (O.M.A.S.). We have examined and treated on 358 @entity0 with O.M.A.S. during the past 10-15 years at two clinics; one was a company's clinic (this company has 15,000 employees) and the other was the clinic at the Dept. of Mental Health, Osaka Prefectural Institute of Public Health during the past 15 years. Discussions have been made on 150 @entity0 whom we directly treated. Our 358 subjects having O.M.A.S. do not include those with secondary O.M.A. resulting from @entity6 , @entity5 , @entity9 and @entity2 . From that reason, our subjects are categorized in a narrow sense, in a category which may be called as " @entity8 ." The results are summarized as follows. 1. The @entity0 with O.M.A.S. were found almost in males and most commonly found among @entity0 in the twenties. 2. The average rate of @entity0 with O.M.A.S. among all the @entity0 who visited two clinics, was 4.1% at our clinic and 16.7% at the company's clinic. 3. At our clinic, the number of @entity0 with O.M.A.S. was followed by the number of those with @entity9 , @entity3 and @entity4 . This trend was also the same at the company's clinic. 4. As the cause of O.M.A.S., we found the following occupational factors; firstly, transposition by selective promotion, secondly, complication of job-quality, and thirdly, promotion to middle management position. As to personal factors, i.e. as to characteristic individual personality we found mostly rigid and serious trait, next @entity1 and egotism, and timidity and nervousness. 5. The relation between the occupational and individual factors was examined from the psychodynamic point of view. From the result, O.M.A.S. was classified into 5 groups which consisted of the core group, dropout group, special job maladjustment group, transient reaction group and others. 6. In conclusion of the above mentioned data, the authors emphasize that it is important to explain and advise by the therapists not only for @entity0 and their families, but also for their colleagues or superiors in their working place.

title: [Studies on the occupational XXXX . With reference to the survey of examinations, etiological factors and treatment].

answer: @entity7


abstract: BACKGROUND: The burden of @entity1 ( @entity1 ) is on the rise especially in developing countries like India. Due to its chronic @entity1 tends to cause many debilitating complications and @entity7 ( @entity7 ) is one of them. The aim of this study is to determine the prevalence of @entity7 among @entity0 attending a tertiary care hospital and to identify the determinants associated with it. DESIGN AND METHODS: A cross sectional study was conducted in Government Wenlock Hospital, Mangalore (India), during January-February 2014. A total of 208 @entity0 with >5 year duration of @entity1 were asked to respond to the @entity0 history version of @entity3 Screening Instrument (MNSI) and examinations were conducted after obtaining consent from them. The statistical analysis was done in terms of descriptive statistics and association between variables was tested using logistic regression test. RESULTS: The prevalence of @entity7 using the MNSI history version and MNSI examination were found to be 18.3% and 32.2% respectively. The major determinants associated with @entity7 were found to be male gender (OR: 2.7, CI: 1.4-5.1, P=0.001), smoking (OR: 5.8, CI: 1.9-17.3, P=0.001) and age >40 years (OR: 2.7, CI: 1.2-5.8, P=0.011). CONCLUSIONS: The burden of undetected @entity7 was found to be higher among @entity1 , with an especially higher prevalence among males, smokers and those with @entity1 . Interventions in the form of early detection through routine screening, smoking cessation and regular follow up examinations would go a long way in reducing the @entity5 among @entity1 and improve their quality of life significantly. Significance for public healthThe findings of the current research hold importance since @entity1 is one of the leading causes of morbidity and mortality across the world. Due to its chronic nature and effects of hyperglycaemia, @entity1 tends to be associated with many comorbidities, like @entity7 , @entity2 , @entity6 etc. The presence of @entity7 leads to a reduced quality of life among @entity1 @entity0 due to the @entity4 and consequent gangrenes andamputation. The concept of secondary prevention can be applied to the prevention of @entity7 using easy to apply screening tools and thus help in early diagnosis and treatment to reduce the burden of this debilitating illness.

title: XXXX and its Determinants among @entity0 Attending a Tertiary Health Care Centre in Mangalore, India.

answer: @entity7


abstract: BACKGROUND: The burden of @entity1 ( @entity1 ) is on the rise especially in developing countries like India. Due to its chronic @entity1 tends to cause many debilitating complications and @entity7 ( @entity7 ) is one of them. The aim of this study is to determine the prevalence of @entity7 among @entity0 attending a tertiary care hospital and to identify the determinants associated with it. DESIGN AND METHODS: A cross sectional study was conducted in Government Wenlock Hospital, Mangalore (India), during January-February 2014. A total of 208 @entity0 with >5 year duration of @entity1 were asked to respond to the @entity0 history version of @entity3 Screening Instrument (MNSI) and examinations were conducted after obtaining consent from them. The statistical analysis was done in terms of descriptive statistics and association between variables was tested using logistic regression test. RESULTS: The prevalence of @entity7 using the MNSI history version and MNSI examination were found to be 18.3% and 32.2% respectively. The major determinants associated with @entity7 were found to be male gender (OR: 2.7, CI: 1.4-5.1, P=0.001), smoking (OR: 5.8, CI: 1.9-17.3, P=0.001) and age >40 years (OR: 2.7, CI: 1.2-5.8, P=0.011). CONCLUSIONS: The burden of undetected @entity7 was found to be higher among @entity1 , with an especially higher prevalence among males, smokers and those with @entity1 . Interventions in the form of early detection through routine screening, smoking cessation and regular follow up examinations would go a long way in reducing the @entity5 among @entity1 and improve their quality of life significantly. Significance for public healthThe findings of the current research hold importance since @entity1 is one of the leading causes of morbidity and mortality across the world. Due to its chronic nature and effects of hyperglycaemia, @entity1 tends to be associated with many comorbidities, like @entity7 , @entity2 , @entity6 etc. The presence of @entity7 leads to a reduced quality of life among @entity1 @entity0 due to the @entity4 and consequent gangrenes andamputation. The concept of secondary prevention can be applied to the prevention of @entity7 using easy to apply screening tools and thus help in early diagnosis and treatment to reduce the burden of this debilitating illness.

title: @entity7 and its Determinants among XXXX Attending a Tertiary Health Care Centre in Mangalore, India.

answer: @entity0


abstract: OBJECTIVE: The aims of this article are to review the imaging characteristics of ischiofemoral impingement (IFI), summarize measurement thresholds for radiologic diagnosis based on a meta-analysis of the literature and raise awareness among radiologists and clinicians of this entity. MATERIALS AND METHODS: A PubMed search restricted to the English language containing the keywords "ischiofemoral impingement" and "quadratus femoris MRI" was performed, and citations in these articles were also used to identify a total of 27 studies discussing ischiofemoral impingement. After excluding case reports and non-representative studies, there were five remaining articles including 193 hip MRIs of IFI in 154 subjects (133 female, 21 male) and 135 asymptomatic control hip MRIs from 74 subjects (55 female, 19 male). Additionally, we performed a retrospective database search of pelvic and hip MRI reports from our institution including the terms "quadratus femoris" or "ischiofemoral impingement" from a 9-year period and 24 hip MRIs from 21 @entity0 (18 female, 3 male) with IFI with 5 asymptomatic contralateral control hip MRIs identified. In all, 217 hip MRIs of IFI and 140 control cases were included. A meta-analysis of these hip MRIs was conducted to determine optimal thresholds of the ischiofemoral space (IFS) and @entity2 ( @entity2 ) for identifying IFI. RESULTS: Cases of IFI showed significantly smaller IFS and @entity2 compared to controls (14.91    4.8 versus 26.01    7.98 and 9.57    3.7 versus 15.97    6.07, measured in mm, respectively, p   <   0.0001 for both). Pooled analysis revealed that for IFS, using a cutoff of    <=15  mm yielded a sensitivity of 76.9  %, specificity of 81.0  % and overall accuracy of 78.3  %. For @entity2 , a cutoff of    <=   10.0  mm resulted in 78.7  % sensitivity, 74.1  % specificity and 77.1  % overall accuracy. CONCLUSION: IFI is a potential cause of @entity1 that can be accurately diagnosed with MRI in conjunction with clinical findings. Using the proposed measurement thresholds may better identify @entity0 with this @entity3 so that optimal treatment options can be pursued.

title: XXXX : a meta-analysis.

answer: @entity3


abstract: During complete medical checkup of proximal gastrointestinal tract, the esophagus pH measurement is an adventive procedure that requires probes usage, which is introduced through the endoscope biopsy channel. Such procedure cannot be used for everyday dynamic treatment control because of its invasiveness. The main aim of this article is to develop an effective everyday quality control of @entity1 non-traumatic antisecretory treatment. We solve the problem by measuring the air-ionic esophagus internal environment characteristics with the help of the air exhaled by the @entity0 analysis. Initial examination is provided during endoscopic research in the period of @entity0 's planned checkup. Esophagus air tests are get through biopsy channel and analyzed by computer air-ionic complex. The range of air-ionic concentration in the esophagus air content is 0.060-0.040 (60-40%) in electrical voltage 0.020-0.050 V, which corresponds to pH 5.0-7.0. The esophagus air content indexes, received from primary samples are used as gauging for air-ionic characteristics of air exhausted by @entity0 . Hereafter, during the therapy course we study only air samples exhausted by the @entity0 on a daily basis. Air-ionic esophageal pH - measurement is used during checkup and treatment of 42 @entity0 with @entity2 diagnose. Parallel usage of invasive esophageal pH determination method demonstrated complete results match. Thus, the proposed method is an advanced non-invasive diagnostic method, which allows to measure intra-esophagus pH indexes and provides probable assessment of antisecretory drugs treatment efficacy with an ability of therapeutic course operative correction.

title: Dynamic control of pH in XXXX treatment.

answer: @entity1


abstract: BACKGROUND: Using a simple standing-up test in normotensive subjects, we evaluated orthostatic upright postural blood pressure (BP) changes and autonomic nervous function, as well as the relationship between orthostatic BP changes and subclinical markers of @entity6 . METHODS: A total of 515 normotensive subjects aged 35-75 years (58.4  10.0 years) were enrolled. We measured body mass index (BMI), @entity9 (DBP), serum lipids, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein (hs-CRP), and urinary albumin-to- @entity7 ratio. Brachial to ankle pulse wave velocity (baPWV) and carotid mean @entity1 ( @entity1 ) were measured. @entity0 underwent a simple standing-up test involving sitting then standing for 2 minutes each, followed again by sitting. To evaluate autonomic fluctuations, we calculated the coefficient of variation of the R-R interval, the ratio of low to high frequency heart rate variability (LF/HF), and the coefficient of component variance of high frequency. RESULTS: @entity9 and DBP decreased when standing, with a reduction of @entity9 when changing position of -8.0  10.2mm Hg. @entity5 ( @entity5 ) produced a significantly higher @entity9 than without @entity5 . The baPWV was significantly higher in @entity5 than in without @entity5 . Stepwise regression analysis adjusted for age, sex, BMI, baseline @entity9 , @entity8 , high-density lipoprotein @entity3 , low-density lipoprotein @entity3 , fasting @entity4 , HbA1c, hs-CRP, @entity1 , late systolic peak of the pressure wave form ( @entity10 ), and baPWV confirmed that baPWV, @entity10 , and @entity8 were independently related to orthostatic BP changes. Multiple regression analyses showed that a decrease in @entity9 as well as baseline @entity9 , age, BMI, and fasting @entity4 were independent determinants of @entity2 . CONCLUSIONS: We have shown that increased arterial stiffness was associated with @entity5 during a standing-up test. Arterial stiffness may contribute to greater BP responses to postural changes from standing.

title: Orthostatic Blood Pressure Changes and Subclinical Markers of XXXX .

answer: @entity6


abstract: UNASSIGNED: Background and purpose - There is no consensus on which type of shoulder prosthesis should be used in @entity0 with @entity2 ( @entity2 ). We describe @entity0 with @entity2 who were treated with shoulder replacement, regarding @entity0 -reported outcome, prosthesis survival, and causes of revision, and we compare outcome after @entity5 ( @entity5 ) and @entity5 ( @entity5 ). @entity0 and methods - We used data from the national Danish Shoulder Arthroplasty Registry and included @entity0 with @entity2 who underwent shoulder arthroplasty in Denmark between 2006 and 2010. @entity0 -reported outcome was obtained 1-year postoperatively using the Western Ontario @entity4 of the Shoulder index (WOOS), and rates of revision were calculated by checking revisions reported until December 2011. The @entity0 -reported outcome of @entity5 was compared to that of @entity5 using regression analysis with adjustment for age, sex, and previous surgery. Results - During the study period, 167 @entity0 underwent shoulder arthroplasty because of @entity2 , 80 (48%) of whom received @entity5 and 34 (26%) of whom received @entity5 . 16 @entity0 were treated with @entity3 ( @entity3 ), and 24 were treated with reverse shoulder arthroplasty (rTSA). 130 @entity0 returned a completed questionnaire, and the total mean WOOS score was 63. The cumulative 5-year revision rate was 7%. Most revisions occurred after @entity5 , with a revision rate of 14%. Mean WOOS score was similar for @entity5 and for @entity5 . Interpretation - This study shows that shoulder arthroplasty, regardless of design, is a good option in terms of reducing @entity1 and improving function in @entity2 @entity0 . The high revision rate in the @entity5 group suggests that other designs may offer better implant survival. However, this should be confirmed in larger studies.

title: Resurfacing shoulder arthroplasty for the treatment of severe XXXX .

answer: @entity2


abstract: This study was aimed to investigate the effect of stress induced by high-intensity exercises on the cardiovascular system. In the epidemiological investigation, 200 subjects (test group) engaged in special high-intensity exercises, and 97 who lived and worked in the same environment and conditions as those in the test group, but did not participate in the exercises served as controls. In the second part of the study, 50 @entity0 were randomly divided into control group, exhaustive swimming group, white noise group, exhaustive swimming plus white noise group, and pioglitazone intervention group. The results showed that the plasma concentrations of the @entity1 markers heart fatty acid-binding protein (H-FABP), @entity4 ( @entity4 ), b-endorphin (b-EP) and levels of psychological stress were significantly increased in test group as compared with control group; special high-intensity exercises resulted in a significant elevation of the incidence of @entity2 . Animal experiments showed that the plasma levels of corticosterone (CORT) and troponin I (TnI) were raised while the level of SOD was reduced in exhaustive swimming group, white noise group, and exhaustive swimming plus white noise group. The expression levels of PPARy mRNA and protein were decreased in myocardial tissues in these groups as well. HE staining showed no remarkable change in myocardial tissues in all the groups. Treatment with pioglitazone significantly decreased the plasma levels of TnI and CORT, while increased the level of SOD and the expression levels of PPARy mRNA and protein. It was concluded that the high-intensity exercises may induce a heavy physical and psychological stress and predispose the subjects to accumulated @entity3 ; high-intensity exercises also increases the incidence of @entity2 and @entity1 . PPARy may be involved in the physical and psychological changes induced by high-intensity exercises.

title: Association between cardiac changes and stress, and the effect of peroxisome proliferator-activated receptor-y on stress-induced XXXX in @entity0 .

answer: @entity1


abstract: This study was aimed to investigate the effect of stress induced by high-intensity exercises on the cardiovascular system. In the epidemiological investigation, 200 subjects (test group) engaged in special high-intensity exercises, and 97 who lived and worked in the same environment and conditions as those in the test group, but did not participate in the exercises served as controls. In the second part of the study, 50 @entity0 were randomly divided into control group, exhaustive swimming group, white noise group, exhaustive swimming plus white noise group, and pioglitazone intervention group. The results showed that the plasma concentrations of the @entity1 markers heart fatty acid-binding protein (H-FABP), @entity4 ( @entity4 ), b-endorphin (b-EP) and levels of psychological stress were significantly increased in test group as compared with control group; special high-intensity exercises resulted in a significant elevation of the incidence of @entity2 . Animal experiments showed that the plasma levels of corticosterone (CORT) and troponin I (TnI) were raised while the level of SOD was reduced in exhaustive swimming group, white noise group, and exhaustive swimming plus white noise group. The expression levels of PPARy mRNA and protein were decreased in myocardial tissues in these groups as well. HE staining showed no remarkable change in myocardial tissues in all the groups. Treatment with pioglitazone significantly decreased the plasma levels of TnI and CORT, while increased the level of SOD and the expression levels of PPARy mRNA and protein. It was concluded that the high-intensity exercises may induce a heavy physical and psychological stress and predispose the subjects to accumulated @entity3 ; high-intensity exercises also increases the incidence of @entity2 and @entity1 . PPARy may be involved in the physical and psychological changes induced by high-intensity exercises.

title: Association between cardiac changes and stress, and the effect of peroxisome proliferator-activated receptor-y on stress-induced @entity1 in XXXX .

answer: @entity0


abstract: An operation avoiding a permanent ileostomy is described for @entity0 with @entity1 . The colon and upper half of the rectum are excised and the remaining inflamed mucosa is stripped from the rectal stump down to the dentate line of the anal canal. After excision of all diseased tissue, a reservoir is constructed from the terminal 40 cm of the small intestine. An ileoanal @entity2 via the peranal approach is then carried out. Six @entity0 have been treated, five of whom were followed up for 2-21 months (mean 11 months). One @entity0 died 3 weeks after the operation. The other five are currently well, with no disturbance of urinary or sexual function. The average frequency of evacuation is 5 times in 24 h. Three of these evacuate the reservoir spontaneously and one routinely uses a catheter. (One @entity0 still has an ileostomy). Fecal continence is complete in all during the day and night.

title: [Total colectomy, rectomucosectomy, and ileoanal XXXX with the ileum reservoir in treatment of @entity1 ].

answer: @entity2


abstract: An operation avoiding a permanent ileostomy is described for @entity0 with @entity1 . The colon and upper half of the rectum are excised and the remaining inflamed mucosa is stripped from the rectal stump down to the dentate line of the anal canal. After excision of all diseased tissue, a reservoir is constructed from the terminal 40 cm of the small intestine. An ileoanal @entity2 via the peranal approach is then carried out. Six @entity0 have been treated, five of whom were followed up for 2-21 months (mean 11 months). One @entity0 died 3 weeks after the operation. The other five are currently well, with no disturbance of urinary or sexual function. The average frequency of evacuation is 5 times in 24 h. Three of these evacuate the reservoir spontaneously and one routinely uses a catheter. (One @entity0 still has an ileostomy). Fecal continence is complete in all during the day and night.

title: [Total colectomy, rectomucosectomy, and ileoanal @entity2 with the ileum reservoir in treatment of XXXX ].

answer: @entity1


abstract: CONTEXT: Obesity is associated with a pro-inflammatory state and relative @entity13 . @entity5 (E2) is a potential link between these phenomena because it exhibits negative feedback on gonadotropin secretion and also inhibits production of pro-inflammatory cytokines. OBJECTIVE: We sought to examine the effect of @entity5 priming on the @entity3 in @entity1 . DESIGN, SETTING, AND @entity0 : This was an interventional study at an academic center of 11 @entity1 and 10 normal-weight (NW) @entity0 . INTERVENTION: A frequent blood-sampling study and one month of daily urinary collection were performed before and after administration of transdermal @entity4 0.1 mg/d for one entire menstrual cycle. MAIN OUTCOME MEASURES: Serum LH and FSH before and after @entity9 stimulation, and urinary @entity5 and @entity11 metabolites were measured. RESULTS: E2 increased LH pulse amplitude and FSH response to @entity9 (P = .048, and P < .03, respectively) in @entity1 but not NW @entity0 . After E2 priming, ovulatory @entity1 but not NW @entity0 had a 25% increase in luteal @entity11 (P = .01). Obese @entity0 had significantly higher baseline @entity6 , @entity8 , @entity12 , and IL-12 compared with NW (all P < .05); these levels were reduced after E2 (-6% for @entity10 , -21% for @entity7 , -5% for @entity12 , -5% for IL-12; all P < .05) in @entity1 but not in NW @entity0 . CONCLUSIONS: E2 priming seems to improve @entity3 function and systemic @entity2 in ovulatory, @entity1 @entity0 . Reducing @entity2 at the pituitary level may decrease the burden of @entity1 on fertility.

title: XXXX Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese @entity0 .

answer: @entity4


abstract: CONTEXT: Obesity is associated with a pro-inflammatory state and relative @entity13 . @entity5 (E2) is a potential link between these phenomena because it exhibits negative feedback on gonadotropin secretion and also inhibits production of pro-inflammatory cytokines. OBJECTIVE: We sought to examine the effect of @entity5 priming on the @entity3 in @entity1 . DESIGN, SETTING, AND @entity0 : This was an interventional study at an academic center of 11 @entity1 and 10 normal-weight (NW) @entity0 . INTERVENTION: A frequent blood-sampling study and one month of daily urinary collection were performed before and after administration of transdermal @entity4 0.1 mg/d for one entire menstrual cycle. MAIN OUTCOME MEASURES: Serum LH and FSH before and after @entity9 stimulation, and urinary @entity5 and @entity11 metabolites were measured. RESULTS: E2 increased LH pulse amplitude and FSH response to @entity9 (P = .048, and P < .03, respectively) in @entity1 but not NW @entity0 . After E2 priming, ovulatory @entity1 but not NW @entity0 had a 25% increase in luteal @entity11 (P = .01). Obese @entity0 had significantly higher baseline @entity6 , @entity8 , @entity12 , and IL-12 compared with NW (all P < .05); these levels were reduced after E2 (-6% for @entity10 , -21% for @entity7 , -5% for @entity12 , -5% for IL-12; all P < .05) in @entity1 but not in NW @entity0 . CONCLUSIONS: E2 priming seems to improve @entity3 function and systemic @entity2 in ovulatory, @entity1 @entity0 . Reducing @entity2 at the pituitary level may decrease the burden of @entity1 on fertility.

title: @entity4 Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese XXXX .

answer: @entity0


abstract: BACKGROUND: Thresholds for spinal pelvic parameters in @entity1 ( @entity1 ) were previously defined in North American @entity0 and are commonly used to guide surgical planning. However, it is unclear whether these same threshold parameters can be more widely applied in other geographic regions and in other ethnicities. OBJECTIVE: To evaluate the variation in the radiographic disability thresholds between North American and Japanese @entity1 populations and to adjust sagittal modifier thresholds accordingly. METHODS: Retrospective case series of 717 @entity0 with @entity1 who had baseline radiographs and @entity2 Index (ODI) from North America (n = 518) and Japan (n = 199) were studied. @entity0 were compared at baseline for ODI, ODI offset from age- and ethnic-specific values (ODIni), and radiographic parameters. RESULTS: Significant differences in classification were observed: A greater proportion of Japanese @entity0 had marked pelvic @entity1 , whereas a greater proportion of @entity5 @entity0 had marked @entity1 ; no difference in the pelvic incidence-lumbar @entity4 mismatch sagittal modifier was observed. Health-related quality-of-life scores also differed, with a greater ODI raw value observed in the @entity5 @entity0 but similar ODIni scores between cohorts. Stratifying ODIni scores by sagittal modifier grades revealed similar disability scores corresponding to the 0 to + thresholds for pelvic tilt, pelvic incidence-lumbar @entity4 mismatch, and sagittal vertical axis across ethnicities. Finally, linear regression analysis demonstrated that compared with @entity5 @entity0 , Japanese @entity0 had a lower estimated ODI corresponding to established thresholds of @entity1 . CONCLUSION: Our findings demonstrate significant variability in health-related quality-of-life measures and radiographic parameters between North American and Japanese @entity0 , supporting the need for population-adjusted sagittal modifiers to more accurately classify @entity1 . ABBREVIATIONS: @entity1 , adult spinal deformityHRQOL, health-related quality of lifeLL, lumbar lordosisODI, @entity2 IndexODIni, @entity2 Index need for improvementPCS, physical component summaryPI, pelvic incidencePI-LL, pelvic incidence-lumbar @entity4 mismatchPT, pelvic tiltSRS, Scoliosis Research SocietySVA, sagittal vertical axisTK, @entity3 .

title: Geographic and Ethnic Variations in Radiographic Disability Thresholds: Analysis of North American and Japanese Operative Adult XXXX .

answer: @entity1


abstract: UNASSIGNED: An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related @entity1 . In this context, it has been reported that different pancreatic compartments from @entity0 were affected according to the fat composition consumed. Since there is a close relationship between mitochondria, oxidative stress and aging, an experimental approach has been developed to gain more insight into this process in the pancreas. A low dosage of @entity3 was administered life-long in @entity0 in order to try to prevent pancreatic aging-related alterations associated to some dietary fat sources. According to that, three groups of @entity0 were fed normocaloric diets containing @entity3 ( @entity2 ) for two years, where virgin olive, sunflower, or fish oil was included as unique fat source. Pancreatic samples for microscopy and blood samples were collected at the moment of euthanasia. The main finding is that @entity2 supplementation gives different results according to fat used in diet. When sunflower oil was the main fat in the diet, @entity2 supplementation seems to improve endocrine pancreas structure and in particular b-cell mass resembling positive effects of virgin olive oil. Conversely, @entity2 intake does not seem to improve the structural alterations of exocrine compartment previously observed in fish oil fed @entity0 . Therefore @entity2 may improve pancreatic alterations associated to the chronic intake of some dietary fat sources.

title: Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long XXXX Addition.

answer: @entity3


abstract: PURPOSE: To externally validate the Christodouleas risk model incorporating pathological @entity2 stage, @entity4 ( @entity4 ) count and soft tissue surgical margin (STSM) and stratifying @entity0 who develop locoregional recurrence (LR) after radical cystectomy (RC) for @entity3 ( @entity3 ). In addition, we aimed to generate a new model including established clinicopathological features that were absent in the Christodouleas risk model. METHODS: Prospectively assessed multicenter data from 565 @entity0 undergoing RC for @entity3 in 2011 qualified for final analysis. For the purpose of external validation, risk group stratification according to Christodouleas was performed. Competing-risk models were calculated to compare the cumulative incidences of LR after RC. RESULTS: After a median follow-up of 25  months (interquartile range 19-29), the LR-rate was 11.5  %. The Christodouleas model showed a predictive accuracy of 83.2  % in our cohort. In multivariable competing-risk analysis, @entity2 stage >= @entity5 (HR 4.32, p  <  0.001), positive STSM (HR 2.93, p  =  0.005), @entity1 (HR 3.41, p  <  0.001), the number of removed LNs <10 (HR 2.62, p  <  0.001) and the administration of adjuvant chemotherapy (HR 0.40, p  =  0.008) independently predicted the LR-rate. The resulting risk groups revealed significant differences in LR-rates after 24  months with 4.8  % for low-risk @entity0 , 14.7  % for intermediate-risk @entity0 and 38.9  % for high-risk @entity0 (p  <  0.001 for all), with a predictive accuracy of 85.6  %, respectively. CONCLUSIONS: The Christodouleas risk model has been successfully externally validated in the present prospective series. However, this analysis finds that overall model performance may be improved by incorporating @entity1 . After external validation of the newly proposed risk model, it may be used to identify @entity0 who benefit from an adjuvant therapy and suit for inclusion in clinical trials.

title: Risk stratification for locoregional recurrence after radical cystectomy for XXXX .

answer: @entity3


abstract: UNASSIGNED: Transforming growth factor (TGF)-b1 is the most abundant growth factor in @entity0 bone. Several polymorphisms have been described in the @entity3 gene. To explore the correlation between @entity3 gene single nucleotide polymorphism and the clinicopathological characteristics of @entity2 . TaqMAN PCR technique was used to detect the @entity3 gene polymorphism of 124 @entity0 with @entity2 from last follow-up and 136 healthy controls. The difference of gender, age, and allele frequency between @entity0 group and control group with    (2) text were tested. The relationship between single nucleotide polymorphism and the risk of @entity2 with logistic regression and different survival rates of different genotypic @entity0 with @entity2 through Kaplan-Meier were analyzed. There is no remarkable difference of the three genotypes in @entity3 gene @entity4 locus between the @entity0 group and control group (P   =   0.26). However, there are significant distributive differences in @entity5 genotype (P   =   0.04), which shows that @entity0 carrying TT genotype have more risk to get @entity2 than @entity0 carrying CC genotype (odds ratio (OR)   =   2.10, 95  % confidence interval (CI)   =   1.08-4.05). The percentage of T allele frequency of @entity0 group, as 60.1  %, is larger than the control group, as 48.9  %. By comparing with @entity0 carrying CC genotype, @entity0 carrying TT genotype have two times risk of @entity1 (OR   =   2.30, 95  % CI   =   1.05-5.06), and most of them are in the period of Enneking IIB (OR   =   2.54, 95  % CI   =   1.18-5.51). The survival analysis indicates that there is no any significant decrease when there is recurrence in @entity0 carrying TT genotype. The morbidity and @entity1 of @entity2 are relevant to @entity3 gene @entity5 single nucleotide polymorphism.

title: Correlation between @entity3 gene @entity5 single nucleotide polymorphism and clinicopathological characteristics of XXXX .

answer: @entity2


abstract: UNASSIGNED: Transforming growth factor (TGF)-b1 is the most abundant growth factor in @entity0 bone. Several polymorphisms have been described in the @entity3 gene. To explore the correlation between @entity3 gene single nucleotide polymorphism and the clinicopathological characteristics of @entity2 . TaqMAN PCR technique was used to detect the @entity3 gene polymorphism of 124 @entity0 with @entity2 from last follow-up and 136 healthy controls. The difference of gender, age, and allele frequency between @entity0 group and control group with    (2) text were tested. The relationship between single nucleotide polymorphism and the risk of @entity2 with logistic regression and different survival rates of different genotypic @entity0 with @entity2 through Kaplan-Meier were analyzed. There is no remarkable difference of the three genotypes in @entity3 gene @entity4 locus between the @entity0 group and control group (P   =   0.26). However, there are significant distributive differences in @entity5 genotype (P   =   0.04), which shows that @entity0 carrying TT genotype have more risk to get @entity2 than @entity0 carrying CC genotype (odds ratio (OR)   =   2.10, 95  % confidence interval (CI)   =   1.08-4.05). The percentage of T allele frequency of @entity0 group, as 60.1  %, is larger than the control group, as 48.9  %. By comparing with @entity0 carrying CC genotype, @entity0 carrying TT genotype have two times risk of @entity1 (OR   =   2.30, 95  % CI   =   1.05-5.06), and most of them are in the period of Enneking IIB (OR   =   2.54, 95  % CI   =   1.18-5.51). The survival analysis indicates that there is no any significant decrease when there is recurrence in @entity0 carrying TT genotype. The morbidity and @entity1 of @entity2 are relevant to @entity3 gene @entity5 single nucleotide polymorphism.

title: Correlation between @entity3 gene XXXX single nucleotide polymorphism and clinicopathological characteristics of @entity2 .

answer: @entity5


abstract: UNASSIGNED: Transforming growth factor (TGF)-b1 is the most abundant growth factor in @entity0 bone. Several polymorphisms have been described in the @entity3 gene. To explore the correlation between @entity3 gene single nucleotide polymorphism and the clinicopathological characteristics of @entity2 . TaqMAN PCR technique was used to detect the @entity3 gene polymorphism of 124 @entity0 with @entity2 from last follow-up and 136 healthy controls. The difference of gender, age, and allele frequency between @entity0 group and control group with    (2) text were tested. The relationship between single nucleotide polymorphism and the risk of @entity2 with logistic regression and different survival rates of different genotypic @entity0 with @entity2 through Kaplan-Meier were analyzed. There is no remarkable difference of the three genotypes in @entity3 gene @entity4 locus between the @entity0 group and control group (P   =   0.26). However, there are significant distributive differences in @entity5 genotype (P   =   0.04), which shows that @entity0 carrying TT genotype have more risk to get @entity2 than @entity0 carrying CC genotype (odds ratio (OR)   =   2.10, 95  % confidence interval (CI)   =   1.08-4.05). The percentage of T allele frequency of @entity0 group, as 60.1  %, is larger than the control group, as 48.9  %. By comparing with @entity0 carrying CC genotype, @entity0 carrying TT genotype have two times risk of @entity1 (OR   =   2.30, 95  % CI   =   1.05-5.06), and most of them are in the period of Enneking IIB (OR   =   2.54, 95  % CI   =   1.18-5.51). The survival analysis indicates that there is no any significant decrease when there is recurrence in @entity0 carrying TT genotype. The morbidity and @entity1 of @entity2 are relevant to @entity3 gene @entity5 single nucleotide polymorphism.

title: Correlation between XXXX gene @entity5 single nucleotide polymorphism and clinicopathological characteristics of @entity2 .

answer: @entity3


abstract: Fifty-four @entity0 with @entity6 due to benign stricture and @entity1 underwent airway reconstruction with a molded Silicone prosthesis (Neville Prosthesis). In 40 @entity0 , the @entity5 was reconstructed with a straight prosthesis; of these 29 had a postintubation stricture and 11 a @entity1 . In the former group, there was one early death from erosion of the innominate artery and five late @entity2 from a variety of causes. The @entity3 were related to @entity4 at the anastomotic site in four @entity0 and were due to the use of non-absorbable suture material. @entity4 occurred in two @entity0 and were successfully treated with fulguration. The lesion was resected and the @entity5 reconstructed with the prosthesis in eight individuals, five of whom are alive, one to six years postoperatively. Of the three @entity0 , in whom the prosthesis served as an intraluminal stent, one who received irradiation is alive three years after operation. In 14 @entity0 , in whom a carinal resection was performed for @entity1 , five individuals are alive, from one to eleven years after surgery. There were four suture line @entity4 in the entire group. All of the @entity2 were attributable to residual or disseminated @entity1 .

title: Reconstruction of the XXXX and stem bronchi with Neville prosthesis.

answer: @entity5


abstract: BACKGROUND: The benefits of CRT for symptomatic @entity2 ( @entity2 ) @entity0 with a wide QRS and reduced left ventricular ejection fraction (LVEF  <=35%), are well established .Post-hoc subgroup analyses suggest that CRT benefit may extend to @entity0 with LVEF >35%. METHODS: The MIRACLE EF was a prospective, randomized, controlled, double-blinded study to evaluate CRT-P in @entity2 @entity0 with LBBB and with LVEF of 36%-50% and no previous pacing or @entity3 . The primary endpoint was a composite of time to first @entity2 event or @entity1 . All @entity0 were implanted with a CRT-P and randomized 2:1 to @entity4 OFF groups. The minimum follow up time was 24months. RESULTS: The MIRACLE EF study was stopped for enrollment futility after 13months and enrolling only 44 @entity0 . The main difficulties in recruiting @entity0 were lack of eligible @entity0 , previous @entity3 implants, and the reluctance of institutions, @entity0 or physicians to enroll in the study which included a potential 5year CRT OFF period. CONCLUSION: Despite a careful design, identification and randomization of eligible @entity0 were challenging and a trial to assess morbidity and mortality trial was not feasible. The MIRACLE EF experience illustrates the difficulties of designing a scientifically robust but feasible study to assess potential new indications for implantable devices. Smaller randomized studies with surrogate endpoints may therefore be more reasonable, although the potential impact of such studies on clinical practice, guidelines, and reimbursement remain to be determined.

title: Cardiac resynchronization therapy in chronic XXXX with moderately reduced left ventricular ejection fraction: Lessons from the Multicenter InSync Randomized Clinical Evaluation MIRACLE EF study.

answer: @entity2


abstract: UNASSIGNED: Twospotted spider mite, @entity2 Koch, is an important pest of peppermint in California, USA. Spider mite feeding on peppermint leaves causes physiological changes in the plant, which coupling with the favorable environmental condition can lead to @entity1 . Significant yield loss can occur in absence of pest monitoring and timely management. Understating the within-field spatial distribution of @entity2 is critical for the development of reliable sampling plan. The study reported here aims to characterize the spatial distribution of @entity1 in four commercial peppermint fields in northern California using spatial techniques, variogram and Spatial Analysis by Distance IndicEs (SADIE). Variogram analysis revealed that there was a strong evidence for spatially dependent (aggregated) mite population in 13 of 17 sampling dates and the physical distance of the aggregation reached maximum to 7  m in peppermint fields. Using SADIE, 11 of 17 sampling dates showed aggregated distribution pattern of @entity1 . Combining results from variogram and SADIE analysis, the @entity0 of @entity2 was evident in all four fields for all 17 sampling dates evaluated. Comparing spatial association using SADIE, ca. 62  % of the total sampling pairs showed a positive association of mite spatial distribution patterns between two consecutive sampling dates, which indicates a strong spatial and temporal stability of @entity1 in peppermint fields. These results are discussed in relation to behavior of spider mite distribution within field, and its implications for improving sampling guidelines that are essential for effective pest monitoring and management.

title: Characterization of spatial distribution of XXXX in peppermint in California and implication for improving sampling plan.

answer: @entity2


abstract: AIM: To investigate the treatment strategies and long-term outcomes of radiofrequency ablation (RFA) of @entity3 ( @entity3 ) in difficult locations and to compare the results with non-difficult @entity3 . METHODS: From 2004 to 2012, a total of 470 @entity3 @entity0 underwent ultrasound-guided percutaneous RFA. Among these @entity3 @entity0 , 382 with @entity1 located  <= 5 mm from a major vessel/bile duct (n = 87), from peripheral important structures (n = 232) or from the liver capsule (n = 63) were regarded as difficult cases. There were 331 male @entity0 and 51 female @entity0 , with an average age of 55.3    10.1 years old. A total of 235 and 147 @entity0 had @entity0 -Pugh class A and class B liver function, respectively. The average @entity1 size was 3.4    1.2 cm. Individual treatment strategies were developed to treat these difficult cases. During the same period, 88 @entity3 @entity0 with @entity1 that were not in difficult locations served as the control group. In the control group, 74 @entity0 were male, and 14 @entity0 were female, with an average age of 57.4    11.8 years old. Of these, 62 @entity0 and 26 @entity0 had @entity0 -Pugh class A and class B liver function, respectively. Regular follow-up after RFA was performed to assess treatment efficacy. Survival results were generated from Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression model. RESULTS: Early @entity1 @entity2 rate in the difficult group was similar to that in the control group (97.6% vs 94.3%, P = 0.080). The complication rate in the difficult group was significantly higher than that in the control group (4.9% vs 0.8%, P = 0.041). The follow-up period ranged from 6 to 116 mo, with an average of 28    22.4 mo. Local progression rate in the difficult group was significantly higher than that in the control group (12.7% vs 7.1%, P = 0.046). However, the 1-, 3-, 5-, and 7-year overall survival rates in the difficult group were not significantly different from those in the control group (84.3%, 54.4%, 41.2%, and 29.9% vs 92.5%, 60.3%, 43.2%, and 32.8%, respectively, P = 0.371). Additionally, a multivariate analysis revealed that @entity1 location was not a significant risk factor for survival. CONCLUSION: There was no significant difference in long-term overall survival between the two groups even though the local progression rate was higher in the difficult group.

title: Radiofrequency ablation of XXXX in difficult locations: Strategies and long-term outcomes.

answer: @entity3


abstract: A 34-year-old @entity0 presented at our hospital with @entity3 due to overeating. Acute @entity5 was diagnosed. The @entity0 was hospitalized, and nasogastric decompression was initiated. On hospitalization day 3, she developed shock, and her respiratory state deteriorated, requiring intubation and mechanical ventilation. Nasogastric decompression contributed to the improvement in her clinical condition. She was discharged 3 mo after admission. During outpatient follow-up, her dietary intake decreased, and her body weight gradually decreased by 14 kg. An upper gastrointestinal series and endoscopy revealed @entity4 ; therefore, we performed gastrojejunostomy 18 mo after her initial admission. The @entity0 was discharged from the hospital with no @entity2 . @entity1 and perforation due to overeating-induced @entity5 are life-threatening conditions. Surgical intervention may be required if delayed @entity4 occurs after conservative treatment. We report a case of @entity4 due to overeating-induced @entity5 treated by gastrojejunostomy 18 mo after the initial presentation.

title: Gastrojejunostomy for @entity4 after acute XXXX due to overeating.

answer: @entity5


abstract: A 34-year-old @entity0 presented at our hospital with @entity3 due to overeating. Acute @entity5 was diagnosed. The @entity0 was hospitalized, and nasogastric decompression was initiated. On hospitalization day 3, she developed shock, and her respiratory state deteriorated, requiring intubation and mechanical ventilation. Nasogastric decompression contributed to the improvement in her clinical condition. She was discharged 3 mo after admission. During outpatient follow-up, her dietary intake decreased, and her body weight gradually decreased by 14 kg. An upper gastrointestinal series and endoscopy revealed @entity4 ; therefore, we performed gastrojejunostomy 18 mo after her initial admission. The @entity0 was discharged from the hospital with no @entity2 . @entity1 and perforation due to overeating-induced @entity5 are life-threatening conditions. Surgical intervention may be required if delayed @entity4 occurs after conservative treatment. We report a case of @entity4 due to overeating-induced @entity5 treated by gastrojejunostomy 18 mo after the initial presentation.

title: Gastrojejunostomy for XXXX after acute @entity5 due to overeating.

answer: @entity4


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a major cause of @entity5 and disability in all age groups. Among @entity3 , penetrating @entity3 (PTBI) have the worst prognosis and represent the leading cause of @entity3 -related morbidity and @entity5 . However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI @entity1 model: penetrating ballistic-like @entity8 (PBBI). Early after injury, regional cerebral @entity0 tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, @entity7 uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24   hours after PBBI revealed an incomplete overlap of @entity6 and @entity4 . As expected, the injury core had the most severe @entity6 and @entity4 . However, in the peri-lesional area, despite similar @entity6 , there was lesser @entity4 . Given our findings, the data suggest the presence of two distinct zones of @entity2 , of which only one recovers. We anticipate the peri-lesional area encompassing the @entity9 , could be salvaged by acute therapies.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 11 February 2015; doi:10.1038/jcbfm.2014.243.

title: XXXX and @entity0 metabolism after penetrating ballistic-like @entity8 .

answer: @entity7


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a major cause of @entity5 and disability in all age groups. Among @entity3 , penetrating @entity3 (PTBI) have the worst prognosis and represent the leading cause of @entity3 -related morbidity and @entity5 . However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI @entity1 model: penetrating ballistic-like @entity8 (PBBI). Early after injury, regional cerebral @entity0 tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, @entity7 uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24   hours after PBBI revealed an incomplete overlap of @entity6 and @entity4 . As expected, the injury core had the most severe @entity6 and @entity4 . However, in the peri-lesional area, despite similar @entity6 , there was lesser @entity4 . Given our findings, the data suggest the presence of two distinct zones of @entity2 , of which only one recovers. We anticipate the peri-lesional area encompassing the @entity9 , could be salvaged by acute therapies.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 11 February 2015; doi:10.1038/jcbfm.2014.243.

title: @entity7 and XXXX metabolism after penetrating ballistic-like @entity8 .

answer: @entity0


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a major cause of @entity5 and disability in all age groups. Among @entity3 , penetrating @entity3 (PTBI) have the worst prognosis and represent the leading cause of @entity3 -related morbidity and @entity5 . However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI @entity1 model: penetrating ballistic-like @entity8 (PBBI). Early after injury, regional cerebral @entity0 tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, @entity7 uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24   hours after PBBI revealed an incomplete overlap of @entity6 and @entity4 . As expected, the injury core had the most severe @entity6 and @entity4 . However, in the peri-lesional area, despite similar @entity6 , there was lesser @entity4 . Given our findings, the data suggest the presence of two distinct zones of @entity2 , of which only one recovers. We anticipate the peri-lesional area encompassing the @entity9 , could be salvaged by acute therapies.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 11 February 2015; doi:10.1038/jcbfm.2014.243.

title: @entity7 and @entity0 metabolism after penetrating ballistic-like XXXX .

answer: @entity8


abstract: OBJECTIVES: The aim of the study was to evaluate @entity9 - @entity7 effects on the QTc in youth with @entity10 . @entity9 is a partial agonist that is an effective treatment for @entity10 . Compared with @entity1 , it has a lower risk of @entity3 in adults, but is less studied in the youth. It may also reduce the risk of @entity6 ( @entity6 )-an uncommon variant of polymorphic @entity5 -that can result in @entity4 , @entity8 , and @entity2 . METHODS: Secondary analysis of the electrocardiogram data from 95 individuals who participated in a multisite trial for youth with @entity10 . The @entity0 were randomized to a 2-week (DETOX) or a 12-week course of @entity9 - @entity7 (BUP). At baseline, 12-lead electrocardiograms were done at weeks 4 and 12, and QTc intervals were hand-measured and calculated using Bazett formula. Increases above 60 milliseconds were considered clinically significant, and readings above 450 milliseconds (in @entity0 ) and 470 milliseconds (in @entity0 ) indicated a prolonged QTc. RESULTS: Mean QTc intervals were higher for BUP than for DETOX @entity0 at baseline, week 4, and week 12 (P=0.045), and @entity0 had longer mean QTc intervals than @entity0 (P<0.0005). Variations in the QTc intervals were observed in some; however, none were above 500 milliseconds-the level at which risk for @entity6 becomes more significant. CONCLUSIONS: In this randomized trial, the mean QTc at baseline, before randomization, was higher in BUP than in DETOX @entity0 . Minimal changes in the QTc were seen at 4 and 12 weeks in a few @entity0 in both groups. There was no evidence that @entity9 - @entity7 alone increased the QTc to a level that increased the risk for @entity6 .

title: Presence or Absence of QTc Prolongation in @entity9 - @entity7 Among Youth With XXXX .

answer: @entity10


abstract: OBJECTIVES: The aim of the study was to evaluate @entity9 - @entity7 effects on the QTc in youth with @entity10 . @entity9 is a partial agonist that is an effective treatment for @entity10 . Compared with @entity1 , it has a lower risk of @entity3 in adults, but is less studied in the youth. It may also reduce the risk of @entity6 ( @entity6 )-an uncommon variant of polymorphic @entity5 -that can result in @entity4 , @entity8 , and @entity2 . METHODS: Secondary analysis of the electrocardiogram data from 95 individuals who participated in a multisite trial for youth with @entity10 . The @entity0 were randomized to a 2-week (DETOX) or a 12-week course of @entity9 - @entity7 (BUP). At baseline, 12-lead electrocardiograms were done at weeks 4 and 12, and QTc intervals were hand-measured and calculated using Bazett formula. Increases above 60 milliseconds were considered clinically significant, and readings above 450 milliseconds (in @entity0 ) and 470 milliseconds (in @entity0 ) indicated a prolonged QTc. RESULTS: Mean QTc intervals were higher for BUP than for DETOX @entity0 at baseline, week 4, and week 12 (P=0.045), and @entity0 had longer mean QTc intervals than @entity0 (P<0.0005). Variations in the QTc intervals were observed in some; however, none were above 500 milliseconds-the level at which risk for @entity6 becomes more significant. CONCLUSIONS: In this randomized trial, the mean QTc at baseline, before randomization, was higher in BUP than in DETOX @entity0 . Minimal changes in the QTc were seen at 4 and 12 weeks in a few @entity0 in both groups. There was no evidence that @entity9 - @entity7 alone increased the QTc to a level that increased the risk for @entity6 .

title: Presence or Absence of QTc Prolongation in @entity9 - XXXX Among Youth With @entity10 .

answer: @entity7


abstract: OBJECTIVES: The aim of the study was to evaluate @entity9 - @entity7 effects on the QTc in youth with @entity10 . @entity9 is a partial agonist that is an effective treatment for @entity10 . Compared with @entity1 , it has a lower risk of @entity3 in adults, but is less studied in the youth. It may also reduce the risk of @entity6 ( @entity6 )-an uncommon variant of polymorphic @entity5 -that can result in @entity4 , @entity8 , and @entity2 . METHODS: Secondary analysis of the electrocardiogram data from 95 individuals who participated in a multisite trial for youth with @entity10 . The @entity0 were randomized to a 2-week (DETOX) or a 12-week course of @entity9 - @entity7 (BUP). At baseline, 12-lead electrocardiograms were done at weeks 4 and 12, and QTc intervals were hand-measured and calculated using Bazett formula. Increases above 60 milliseconds were considered clinically significant, and readings above 450 milliseconds (in @entity0 ) and 470 milliseconds (in @entity0 ) indicated a prolonged QTc. RESULTS: Mean QTc intervals were higher for BUP than for DETOX @entity0 at baseline, week 4, and week 12 (P=0.045), and @entity0 had longer mean QTc intervals than @entity0 (P<0.0005). Variations in the QTc intervals were observed in some; however, none were above 500 milliseconds-the level at which risk for @entity6 becomes more significant. CONCLUSIONS: In this randomized trial, the mean QTc at baseline, before randomization, was higher in BUP than in DETOX @entity0 . Minimal changes in the QTc were seen at 4 and 12 weeks in a few @entity0 in both groups. There was no evidence that @entity9 - @entity7 alone increased the QTc to a level that increased the risk for @entity6 .

title: Presence or Absence of QTc Prolongation in XXXX - @entity7 Among Youth With @entity10 .

answer: @entity9


abstract: BACKGROUND: @entity2 ( @entity2 ) is prevalent and related to more severe disease in @entity0 with respiratory problems. We evaluated the effects of antireflux therapy in warfare victims of exposure to @entity5 with chronic cough. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled, cross-over study was conducted on 45 cases of @entity3 @entity1 with chronic cough (>= 8 weeks) and @entity2 . @entity0 were randomized into two groups, receiving either 20 mg twice daily @entity4 -placebo (OP) or matching placebo (placebo- @entity4 [PO]) for 4 months, followed by a 1-month washout period and the alternative treatment for 4 months. Assessments included @entity2 and cough, quality of life, and pulmonary function using spirometry. Leicester Cough Questionnaire and SF-36 were used for measuring quality of life. RESULTS: @entity0 in the OP group experienced a more decrease than those in the PO group in severity of Leicester cough scores during the first 4-month of trial. After crossing the groups, the OP group experienced an increase (P = 0.036) and the PO group experienced a nonsignificant decrease (P = 0.104) in the severity of scores. The OP group also experienced improvement in @entity2 symptoms and quality of life at the end of the trial, but changes in the PO group was not significant. There was no significant change in respiratory function indices in any groups. CONCLUSION: Long-term treatment with high-dose @entity4 improved @entity2 as well as cough, and quality of life, but not changed respiratory function indices in @entity3 mustard injured cases with respiratory symptoms.

title: Efficacy of @entity4 on cough, pulmonary function and quality of life of @entity0 with XXXX mustard lung injury: A placebo-control, cross-over clinical trial study.

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) is prevalent and related to more severe disease in @entity0 with respiratory problems. We evaluated the effects of antireflux therapy in warfare victims of exposure to @entity5 with chronic cough. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled, cross-over study was conducted on 45 cases of @entity3 @entity1 with chronic cough (>= 8 weeks) and @entity2 . @entity0 were randomized into two groups, receiving either 20 mg twice daily @entity4 -placebo (OP) or matching placebo (placebo- @entity4 [PO]) for 4 months, followed by a 1-month washout period and the alternative treatment for 4 months. Assessments included @entity2 and cough, quality of life, and pulmonary function using spirometry. Leicester Cough Questionnaire and SF-36 were used for measuring quality of life. RESULTS: @entity0 in the OP group experienced a more decrease than those in the PO group in severity of Leicester cough scores during the first 4-month of trial. After crossing the groups, the OP group experienced an increase (P = 0.036) and the PO group experienced a nonsignificant decrease (P = 0.104) in the severity of scores. The OP group also experienced improvement in @entity2 symptoms and quality of life at the end of the trial, but changes in the PO group was not significant. There was no significant change in respiratory function indices in any groups. CONCLUSION: Long-term treatment with high-dose @entity4 improved @entity2 as well as cough, and quality of life, but not changed respiratory function indices in @entity3 mustard injured cases with respiratory symptoms.

title: Efficacy of XXXX on cough, pulmonary function and quality of life of @entity0 with @entity3 mustard lung injury: A placebo-control, cross-over clinical trial study.

answer: @entity4


abstract: BACKGROUND: @entity2 ( @entity2 ) is prevalent and related to more severe disease in @entity0 with respiratory problems. We evaluated the effects of antireflux therapy in warfare victims of exposure to @entity5 with chronic cough. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled, cross-over study was conducted on 45 cases of @entity3 @entity1 with chronic cough (>= 8 weeks) and @entity2 . @entity0 were randomized into two groups, receiving either 20 mg twice daily @entity4 -placebo (OP) or matching placebo (placebo- @entity4 [PO]) for 4 months, followed by a 1-month washout period and the alternative treatment for 4 months. Assessments included @entity2 and cough, quality of life, and pulmonary function using spirometry. Leicester Cough Questionnaire and SF-36 were used for measuring quality of life. RESULTS: @entity0 in the OP group experienced a more decrease than those in the PO group in severity of Leicester cough scores during the first 4-month of trial. After crossing the groups, the OP group experienced an increase (P = 0.036) and the PO group experienced a nonsignificant decrease (P = 0.104) in the severity of scores. The OP group also experienced improvement in @entity2 symptoms and quality of life at the end of the trial, but changes in the PO group was not significant. There was no significant change in respiratory function indices in any groups. CONCLUSION: Long-term treatment with high-dose @entity4 improved @entity2 as well as cough, and quality of life, but not changed respiratory function indices in @entity3 mustard injured cases with respiratory symptoms.

title: Efficacy of @entity4 on cough, pulmonary function and quality of life of XXXX with @entity3 mustard lung injury: A placebo-control, cross-over clinical trial study.

answer: @entity0


abstract: UNASSIGNED: @entity0 proteins (Hsps) are involved in a variety of critical biological functions, including protein folding, degradation, and translocation and macromolecule assembly, act as molecular chaperones during periods of stress by binding to other proteins. Using expressed sequence tag (EST) and @entity1 ( @entity1 ) transcriptome databases, we identified 27 cDNA sequences encoding the conserved J domain, which is found in DnaJ-type Hsps. Of the 27 J domain-containing sequences, 25 were complete cDNA sequences. We divided them into three types according to the number and presence of conserved domains. By analyzing the gene structures, intron numbers, and conserved domains and constructing a phylogenetic tree, we found that the DnaJ family had undergone convergent evolution, obtaining new domains to expand the diversity of its family members. The acquisition of the new DnaJ domains most likely occurred prior to the evolutionary divergence of prokaryotes and eukaryotes. The expression of DnaJ genes in the @entity1 was generally higher in the fat body. The tissue distribution of @entity2 proteins was detected by western blotting, demonstrating that in the fifth-instar larvae, the @entity2 proteins were expressed at their highest levels in hemocytes, followed by the fat body and head. We also found that the @entity2 transcripts were likely differentially translated in different tissues. Using immunofluorescence cytochemistry, we revealed that in the blood cells, @entity2 was mainly localized in the cytoplasm.

title: Cloning and analysis of DnaJ family members in the XXXX , @entity1 .

answer: @entity1


abstract: UNASSIGNED: @entity0 proteins (Hsps) are involved in a variety of critical biological functions, including protein folding, degradation, and translocation and macromolecule assembly, act as molecular chaperones during periods of stress by binding to other proteins. Using expressed sequence tag (EST) and @entity1 ( @entity1 ) transcriptome databases, we identified 27 cDNA sequences encoding the conserved J domain, which is found in DnaJ-type Hsps. Of the 27 J domain-containing sequences, 25 were complete cDNA sequences. We divided them into three types according to the number and presence of conserved domains. By analyzing the gene structures, intron numbers, and conserved domains and constructing a phylogenetic tree, we found that the DnaJ family had undergone convergent evolution, obtaining new domains to expand the diversity of its family members. The acquisition of the new DnaJ domains most likely occurred prior to the evolutionary divergence of prokaryotes and eukaryotes. The expression of DnaJ genes in the @entity1 was generally higher in the fat body. The tissue distribution of @entity2 proteins was detected by western blotting, demonstrating that in the fifth-instar larvae, the @entity2 proteins were expressed at their highest levels in hemocytes, followed by the fat body and head. We also found that the @entity2 transcripts were likely differentially translated in different tissues. Using immunofluorescence cytochemistry, we revealed that in the blood cells, @entity2 was mainly localized in the cytoplasm.

title: Cloning and analysis of DnaJ family members in the @entity1 , XXXX .

answer: @entity1


abstract: UNASSIGNED: Cognitive-affective flexibility represents the ability to switch between alternative ways of processing emotional stimuli according to situational demands and individual goals. Although @entity1 has been implicated as a mechanism for the development of @entity2 , there is very limited data on this relationship in @entity0 and adolescents. The aim of the current study was to investigate cognitive-affective flexibility in preadolescents (N  =  112, 50 @entity0 , 11-12 and 13-14  years old) and to examine if this ability is related to individual differences in trait @entity2 . Their interplay was assessed using the modified version of the Flexible Item Selection Task (FIST; Jacques and Zelazo 2001) with non-emotional stimuli (geometrical shapes) and the Emotional FIST (EM-FIST) with emotional stimuli (emotional facial expressions). Performance on the EM-FIST indicated that across the whole age range, trials requiring greater cognitive flexibility were more demanding than nonflexible ones, as revealed by both response time and accuracy performance. Moreover, flexibility demands were higher for younger @entity0 than for older ones but only in terms of response speed. Individual differences in trait @entity2 moderated the impact of flexibility only on the EM-FIST. Being flexible on the EM-FIST was more demanding for high trait anxious @entity0 than for their low trait anxious peers. Lastly, overall @entity0 responded faster than @entity0 , but only in the EM-FIST. These findings extend the presently limited literature concerning variability in cognitive-affective flexibility during this sensitive developmental window.

title: A FISTful of Emotion: Individual Differences in Trait XXXX and Cognitive-Affective Flexibility During Preadolescence.

answer: @entity2


abstract: BACKGROUND: @entity1 is an important malignancy in head and neck area and @entity2 ( @entity2 ) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different @entity1 and their correlation with @entity1 invasiveness has been documented. However, most studies have evaluated @entity3 and @entity4 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in @entity0 with laryngeal @entity2 compared to normal subjects and assess any relation with @entity1 clinicopathological findings. MATERIALS AND METHODS: In this case control study, 20 @entity0 with oral @entity2 and 20 healthy subjects were included. Serum levels of @entity3 and @entity4 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. RESULTS: @entity0 with laryngeal @entity2 had significantly higher serum levels of @entity3 (p=0.01) and @entity4 (p=0.03) compared to healthy subjects. @entity0 with higher T stage (T3,4) had significantly higher @entity3 (p=0.04) and @entity4 (p=0.01). There was significant positive correlation between serum levels of @entity3 with T stage (r=0.45, p=0.04) and lymph node involvement (r=0.563, p=0.01) and between levels of @entity4 with T stage (r=0.527, p=0.01). CONCLUSIONS: Our results showed that compared to healthy subjects, both @entity3 and @entity4 are significantly increased in serum of laryngeal @entity2 cases. @entity3 was correlated with lymph node involvement while @entity4 has stronger correlation with T stage compared to @entity3 .

title: Serum Level of Matrix Metalloproteinase-2 and -9 in @entity0 with XXXX and Clinical Significance.

answer: @entity2


abstract: BACKGROUND: @entity1 is an important malignancy in head and neck area and @entity2 ( @entity2 ) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different @entity1 and their correlation with @entity1 invasiveness has been documented. However, most studies have evaluated @entity3 and @entity4 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in @entity0 with laryngeal @entity2 compared to normal subjects and assess any relation with @entity1 clinicopathological findings. MATERIALS AND METHODS: In this case control study, 20 @entity0 with oral @entity2 and 20 healthy subjects were included. Serum levels of @entity3 and @entity4 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. RESULTS: @entity0 with laryngeal @entity2 had significantly higher serum levels of @entity3 (p=0.01) and @entity4 (p=0.03) compared to healthy subjects. @entity0 with higher T stage (T3,4) had significantly higher @entity3 (p=0.04) and @entity4 (p=0.01). There was significant positive correlation between serum levels of @entity3 with T stage (r=0.45, p=0.04) and lymph node involvement (r=0.563, p=0.01) and between levels of @entity4 with T stage (r=0.527, p=0.01). CONCLUSIONS: Our results showed that compared to healthy subjects, both @entity3 and @entity4 are significantly increased in serum of laryngeal @entity2 cases. @entity3 was correlated with lymph node involvement while @entity4 has stronger correlation with T stage compared to @entity3 .

title: Serum Level of Matrix Metalloproteinase-2 and -9 in XXXX with @entity2 and Clinical Significance.

answer: @entity0


abstract: OBJECTIVE: Rehospitalization affects quality of life and health system efficiency. Although this outcome is a common quality indicator, there are few applications for linking evaluation to risk mitigation at the @entity0 level. This study examined risk factors for rehospitalization to develop an application for supporting care planning based on the interRAI @entity3 ( @entity3 ), a commonly available assessment system. METHOD: A retrospective analysis was performed of 53,538 @entity1 inpatients assessed with the interRAI @entity3 in Ontario, Canada, between January 2010 and May 2014. The interRAI @entity3 is a clinical system for assessing demographic variables, service utilization, functional status, and clinical needs. @entity4 models and survival analysis were used to develop the Rehospitalization Clinical Assessment Protocol by predicting 90-day rehospitalization to any inpatient mental health bed. RESULTS: Variables found to significantly predict rehospitalization included 6 or more lifetime hospitalizations (odds ratio [OR] = 1.40), positive symptoms of @entity2 (OR = 1.23), a secondary substance use disorder (OR = 1.13), and being at risk of harm to self (OR = 1.11). Using these variables, the Rehospitalization Clinical Assessment Protocol was derived whereby those at level 2 (highest) were 74% more likely to be rehospitalized within 90 days than those at level 0. By 1-year postdischarge, 30% at level 2 and 18% at level 0 were rehospitalized. CONCLUSIONS: The Rehospitalization Clinical Assessment Protocol is an application supporting care planning for targeting risk of rehospitalization whenever a @entity0 is assessed with the interRAI @entity3 . Further exploration is needed to understand how the use of this Clinical Assessment Protocol, service processes, and health system structures further mediate or moderate @entity1 rehospitalization risk.

title: Psychiatric Rehospitalization: Development of a XXXX -Level Indicator for Care Planning and Quality Assurance.

answer: @entity0


abstract: The incidence of @entity4 ( @entity4 ) in Europe and throughout the world is currently increasing. This is caused by an increase in the number of @entity0 with @entity6 , @entity5 , and by increasing incidence of @entity9 and C.From January 1, 2004 to December 31, 2013, resection or radiofrequency ablation of the liver was done in 360 @entity0 with benign lesions or @entity3 . In 28 @entity0 @entity4 was diagnosed and histologically confirmed (7.8 %). Seven @entity0 had @entity4 associated with @entity8 (25 %), and 21 @entity0 were without histologically confirmed @entity2 (75 %). R0 resection was done in 18 (64 %) @entity0 . @entity7 occurred in 6 (21 %) @entity0 and reoperation due to @entity1 relapse or progression was done eight times in 6 (21 %) @entity0 . One-year and five-year @entity0 ' survivals were 64 % and 10 %, repectively, and did not statistically differ from the survival of the whole set of @entity0 with @entity1 diseases in the given time period.       In the future it will be possible to improve the long-term survival of @entity0 with @entity4 by using screening methods for presymptomatic diagnosis of @entity4 , precise preoperative diagnosis and efforts for R0 resection (Tab. 1, Fig. 4, Ref. 11).

title: Surgical treatment of XXXX .

answer: @entity4


abstract: BACKGROUND: Caregiver burden is a significant issue in the treatment of @entity3 and a known contributor to institutionalization of @entity0 with @entity3 . Published data have documented increased caregiver burden in @entity1 ( @entity1 ) compared to @entity2 ( @entity2 ). Another atypical @entity3 with high-perceived caregiver burden is @entity5 ( @entity5 ), but no formal studies have assessed this perception. The aim of this study was to compare caregiver burden across atypical @entity3 etiologies. METHODS: 76 adults with atypical @entity3 (young-onset @entity2 [YOAD], @entity1 , language variant @entity4 [lvFTD], and @entity5 ) were administered an abbreviated version of the Zarit Burden Interview (ZBI), @entity1 Inventory (NPI-Q), and other assessment instruments during a five-year time period at Johns Hopkins Hospital (JHH). A Cox regression model examined differences between disease categories that impact mean ZBI scores. RESULTS: Mean ZBI scores were significantly different between @entity3 etiologies, with @entity1 and @entity5 having the highest caregiver burden (p = 0.026). Mean NPI-Q caregiver distress scores were highest in @entity1 and @entity5 (p = 0.002), with @entity5 and @entity1 also having the highest number of endorsed symptom domains (p = 0.012). On regression analyses, an interactive variable combining final diagnosis category and NPI-Q total severity score demonstrated statistically significant differences in mean ZBI scores for @entity5 and @entity1 . CONCLUSIONS: This study demonstrates that @entity1 and @entity5 have increased levels of caregiver burden, NPI-Q caregiver distress, total severity scores, and number of endorsed symptom domains. These results suggest that higher caregiver burden in @entity1 and @entity5 are disease specific and possibly related to @entity1 .

title: Caregiver burden in atypical @entity3 : comparing frontotemporal @entity3 , Creutzfeldt-Jakob disease, and XXXX .

answer: @entity2


abstract: BACKGROUND: Caregiver burden is a significant issue in the treatment of @entity3 and a known contributor to institutionalization of @entity0 with @entity3 . Published data have documented increased caregiver burden in @entity1 ( @entity1 ) compared to @entity2 ( @entity2 ). Another atypical @entity3 with high-perceived caregiver burden is @entity5 ( @entity5 ), but no formal studies have assessed this perception. The aim of this study was to compare caregiver burden across atypical @entity3 etiologies. METHODS: 76 adults with atypical @entity3 (young-onset @entity2 [YOAD], @entity1 , language variant @entity4 [lvFTD], and @entity5 ) were administered an abbreviated version of the Zarit Burden Interview (ZBI), @entity1 Inventory (NPI-Q), and other assessment instruments during a five-year time period at Johns Hopkins Hospital (JHH). A Cox regression model examined differences between disease categories that impact mean ZBI scores. RESULTS: Mean ZBI scores were significantly different between @entity3 etiologies, with @entity1 and @entity5 having the highest caregiver burden (p = 0.026). Mean NPI-Q caregiver distress scores were highest in @entity1 and @entity5 (p = 0.002), with @entity5 and @entity1 also having the highest number of endorsed symptom domains (p = 0.012). On regression analyses, an interactive variable combining final diagnosis category and NPI-Q total severity score demonstrated statistically significant differences in mean ZBI scores for @entity5 and @entity1 . CONCLUSIONS: This study demonstrates that @entity1 and @entity5 have increased levels of caregiver burden, NPI-Q caregiver distress, total severity scores, and number of endorsed symptom domains. These results suggest that higher caregiver burden in @entity1 and @entity5 are disease specific and possibly related to @entity1 .

title: Caregiver burden in atypical XXXX : comparing frontotemporal @entity3 , Creutzfeldt-Jakob disease, and @entity2 .

answer: @entity3


abstract: BACKGROUND: Caregiver burden is a significant issue in the treatment of @entity3 and a known contributor to institutionalization of @entity0 with @entity3 . Published data have documented increased caregiver burden in @entity1 ( @entity1 ) compared to @entity2 ( @entity2 ). Another atypical @entity3 with high-perceived caregiver burden is @entity5 ( @entity5 ), but no formal studies have assessed this perception. The aim of this study was to compare caregiver burden across atypical @entity3 etiologies. METHODS: 76 adults with atypical @entity3 (young-onset @entity2 [YOAD], @entity1 , language variant @entity4 [lvFTD], and @entity5 ) were administered an abbreviated version of the Zarit Burden Interview (ZBI), @entity1 Inventory (NPI-Q), and other assessment instruments during a five-year time period at Johns Hopkins Hospital (JHH). A Cox regression model examined differences between disease categories that impact mean ZBI scores. RESULTS: Mean ZBI scores were significantly different between @entity3 etiologies, with @entity1 and @entity5 having the highest caregiver burden (p = 0.026). Mean NPI-Q caregiver distress scores were highest in @entity1 and @entity5 (p = 0.002), with @entity5 and @entity1 also having the highest number of endorsed symptom domains (p = 0.012). On regression analyses, an interactive variable combining final diagnosis category and NPI-Q total severity score demonstrated statistically significant differences in mean ZBI scores for @entity5 and @entity1 . CONCLUSIONS: This study demonstrates that @entity1 and @entity5 have increased levels of caregiver burden, NPI-Q caregiver distress, total severity scores, and number of endorsed symptom domains. These results suggest that higher caregiver burden in @entity1 and @entity5 are disease specific and possibly related to @entity1 .

title: Caregiver burden in atypical @entity3 : comparing frontotemporal XXXX , Creutzfeldt-Jakob disease, and @entity2 .

answer: @entity3


abstract: AIMS: To assess temporal changes in foot ulceration and its risk factors in community-based @entity0 with type 2 @entity1 . METHODS: Baseline data from the longitudinal observational Fremantle @entity1 Study collected from 1993 to 1996 (Phase I) and 2008 to 2011 (Phase II) were analyzed. Generalized linear modeling was used to examine changes in foot @entity3 prevalence and its associates between phases. Multiple logistic regression was used to determine associates of prevalent foot ulceration in individual and pooled phases. RESULTS: There were 16 foot @entity3 among 1296 @entity0 in Phase I (1.2%) and 23 in 1509 Phase II @entity0 (1.5%; P=0.86 after age, sex and race/ethnicity adjustment). Glycemic and non-glycemic cardiovascular risk factors were better in Phase II, but @entity1 duration was longer, @entity5 ( @entity5 ) was more prevalent and more @entity0 were Aboriginal (P<0.001) than in Phase I. In multivariable analysis of both phases and pooled data, @entity1 duration and @entity5 ( @entity5 ) were independent associates of foot ulceration (P <=0.026). Prior hospitalization for @entity3 , @entity2 , any absent pedal pulse and Aboriginality were also significant in the pooled model (P <=0.009). CONCLUSIONS: Strong associations between foot @entity3 and @entity1 duration, @entity5 , symptomatic and clinically-detectable @entity4 were observed. Aboriginality also proved an independent risk factor. Since all these risk factors apart from @entity2 and impalpable foot pulses were more prevalent in Phase II, improved community- and hospital-based foot care between phases are likely to have attenuated the risk of foot @entity3 in Phase II @entity0 .

title: Temporal changes in the prevalence and associates of foot ulceration in type 2 XXXX : The Fremantle @entity1 Study.

answer: @entity1


abstract: AIMS: To assess temporal changes in foot ulceration and its risk factors in community-based @entity0 with type 2 @entity1 . METHODS: Baseline data from the longitudinal observational Fremantle @entity1 Study collected from 1993 to 1996 (Phase I) and 2008 to 2011 (Phase II) were analyzed. Generalized linear modeling was used to examine changes in foot @entity3 prevalence and its associates between phases. Multiple logistic regression was used to determine associates of prevalent foot ulceration in individual and pooled phases. RESULTS: There were 16 foot @entity3 among 1296 @entity0 in Phase I (1.2%) and 23 in 1509 Phase II @entity0 (1.5%; P=0.86 after age, sex and race/ethnicity adjustment). Glycemic and non-glycemic cardiovascular risk factors were better in Phase II, but @entity1 duration was longer, @entity5 ( @entity5 ) was more prevalent and more @entity0 were Aboriginal (P<0.001) than in Phase I. In multivariable analysis of both phases and pooled data, @entity1 duration and @entity5 ( @entity5 ) were independent associates of foot ulceration (P <=0.026). Prior hospitalization for @entity3 , @entity2 , any absent pedal pulse and Aboriginality were also significant in the pooled model (P <=0.009). CONCLUSIONS: Strong associations between foot @entity3 and @entity1 duration, @entity5 , symptomatic and clinically-detectable @entity4 were observed. Aboriginality also proved an independent risk factor. Since all these risk factors apart from @entity2 and impalpable foot pulses were more prevalent in Phase II, improved community- and hospital-based foot care between phases are likely to have attenuated the risk of foot @entity3 in Phase II @entity0 .

title: Temporal changes in the prevalence and associates of foot ulceration in type 2 @entity1 : The Fremantle XXXX Study.

answer: @entity1


abstract: @entity1 ( @entity5 ) is prevalent in @entity2 and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant @entity5 on microbiota. Cirrhotic outpatients with/without @entity5 underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without @entity5 , and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% @entity3 ( @entity3 ), 31% @entity5 ] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and @entity3 without difference in @entity5 . Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p<   =   1.0e-02). Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and higher Enterococcaceae and Enterobacteriaceae were seen in hospitalized @entity0 . Concomitant @entity5 impacted microbiota UNIFRAC (stool, p   =   0.003, mucosa,p   =   0.04) with higher stool Bacteroidaceae and lower Ruminococcaeae. Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations independent of clinical predictors (MELD, @entity3 , PPI). Stool and @entity4 are altered in cirrhotics who get hospitalized with independent prediction using stool Bacteroidaceae and Clostridiales XIV. Concomitant @entity5 distinctly impacts gut microbiota without affecting hospitalizations.

title: Gut Microbiota Alterations can predict Hospitalizations in XXXX Independent of @entity1 .

answer: @entity2