abstract: Gene expression can be regulated by chromatin modifiers, transcription factors and proteins that modulate DNA architecture. Among the latter, AT-hook transcription factors have emerged as multifaceted regulators that can activate or repress broad A/T-rich gene networks. Thus, alterations of AT-hook genes could affect the transcription of multiple genes causing global cell dysfunction. Here we report that targeted deletions of @entity1 @entity9 , a hypothetical @entity6 factor, sensitize @entity1 to pathogen-induced @entity2 and cause @entity5 . Compared with wild-type littermates, @entity9 KO @entity1 appeared weak, failed to thrive and most died by postnatal day 10. Systemic @entity2 , predominantly in the lungs, was accompanied by enhanced leukocyte infiltration and @entity3 . Cytologic, immunohistochemical and molecular analyses revealed @entity7 (+)Gr1(+) neutrophils as major tissue infiltrators, neutrophilic granule protein, cathelin-related antimicrobial peptide and @entity8 as neutrophil-specific chemoattracting factors, @entity4 and interferon-y as proinflammatory mediators, and matrix metalloprotease 9 as a plausible proteolytic trigger of @entity0 . @entity9 KO bone marrow transplants in wild-type recipients reproduced the severe pathogen-induced reactions and confirmed the involvement of neutrophils in acute @entity2 . Moreover, promoter/reporter experiments showed that @entity9 could act as a gene repressor. Our results support the concept of coordinated pathway-specific gene regulation functions modulating the intensity of inflammatory responses, reveal neutrophils as prominent mediators of acute @entity2 and suggest mechanisms underlying the triggering of acute and potentially fatal immune reactions.

title: Coordinate activation of inflammatory gene networks, @entity3 and neonatal death in @entity9 deficient XXXX .

answer: @entity1


abstract: PURPOSE: Acute severe @entity6 (ASL) frequently develops during @entity3 ( @entity3 ) and concurrent @entity4 ( @entity5 ) for high-grade @entity1 (HGG) and is associated with decreased survival. The current study was designed to identify potential predictors of ASL, with a focus on actionable @entity3 -specific dosimetric parameters. METHODS AND MATERIALS: From January 2007 to December 2012, 183 @entity0 with HGG were treated with @entity3 + @entity5 and had available data including @entity2 ( @entity2 ) and radiation dose-volume histogram parameters. ASL was defined as @entity2 of <500/ L within the first 3  months from the start of @entity3 . Stepwise logistic regression analysis was used to determine the most important predictors of ASL. RESULTS: Fifty-three @entity0 (29%) developed ASL. @entity0 with ASL had significantly worse overall survival than those without (median: 12.5 vs 20.2  months, respectively, P<.001). Stepwise logistic regression analysis identified female sex (odds ratio [OR]: 5.30; 95% confidence interval [CI]: 2.46-11.41), older age (OR: 1.05; 95% CI: 1.02-1.09), lower baseline @entity2 (OR: 0.92; 95% CI: 0.87-0.98), and higher brain volume receiving 25 Gy (V25Gy) (OR: 1.03; 95% CI: 1.003-1.05) as the most significant predictors for ASL. Brain V25Gy <56% appeared to be the optimal threshold (OR:  2.36; 95% CI: 1.11-5.01), with an ASL rate of 38% versus 20% above and below this threshold, respectively (P=.006). CONCLUSIONS: Female sex, older age, lower baseline @entity2 , and higher brain V25Gy are significant predictors of ASL during @entity3 + @entity5 therapy for HGG. Maintaining the V25Gy of brain below 56% may reduce the risk of ASL.

title: Clinical and Dosimetric Predictors of Acute @entity6 During Radiation Therapy and Concurrent XXXX for High-Grade @entity1 .

answer: @entity4


abstract: PURPOSE: Acute severe @entity6 (ASL) frequently develops during @entity3 ( @entity3 ) and concurrent @entity4 ( @entity5 ) for high-grade @entity1 (HGG) and is associated with decreased survival. The current study was designed to identify potential predictors of ASL, with a focus on actionable @entity3 -specific dosimetric parameters. METHODS AND MATERIALS: From January 2007 to December 2012, 183 @entity0 with HGG were treated with @entity3 + @entity5 and had available data including @entity2 ( @entity2 ) and radiation dose-volume histogram parameters. ASL was defined as @entity2 of <500/ L within the first 3  months from the start of @entity3 . Stepwise logistic regression analysis was used to determine the most important predictors of ASL. RESULTS: Fifty-three @entity0 (29%) developed ASL. @entity0 with ASL had significantly worse overall survival than those without (median: 12.5 vs 20.2  months, respectively, P<.001). Stepwise logistic regression analysis identified female sex (odds ratio [OR]: 5.30; 95% confidence interval [CI]: 2.46-11.41), older age (OR: 1.05; 95% CI: 1.02-1.09), lower baseline @entity2 (OR: 0.92; 95% CI: 0.87-0.98), and higher brain volume receiving 25 Gy (V25Gy) (OR: 1.03; 95% CI: 1.003-1.05) as the most significant predictors for ASL. Brain V25Gy <56% appeared to be the optimal threshold (OR:  2.36; 95% CI: 1.11-5.01), with an ASL rate of 38% versus 20% above and below this threshold, respectively (P=.006). CONCLUSIONS: Female sex, older age, lower baseline @entity2 , and higher brain V25Gy are significant predictors of ASL during @entity3 + @entity5 therapy for HGG. Maintaining the V25Gy of brain below 56% may reduce the risk of ASL.

title: Clinical and Dosimetric Predictors of Acute @entity6 During Radiation Therapy and Concurrent @entity4 for High-Grade XXXX .

answer: @entity1


abstract: PURPOSE: Acute severe @entity6 (ASL) frequently develops during @entity3 ( @entity3 ) and concurrent @entity4 ( @entity5 ) for high-grade @entity1 (HGG) and is associated with decreased survival. The current study was designed to identify potential predictors of ASL, with a focus on actionable @entity3 -specific dosimetric parameters. METHODS AND MATERIALS: From January 2007 to December 2012, 183 @entity0 with HGG were treated with @entity3 + @entity5 and had available data including @entity2 ( @entity2 ) and radiation dose-volume histogram parameters. ASL was defined as @entity2 of <500/ L within the first 3  months from the start of @entity3 . Stepwise logistic regression analysis was used to determine the most important predictors of ASL. RESULTS: Fifty-three @entity0 (29%) developed ASL. @entity0 with ASL had significantly worse overall survival than those without (median: 12.5 vs 20.2  months, respectively, P<.001). Stepwise logistic regression analysis identified female sex (odds ratio [OR]: 5.30; 95% confidence interval [CI]: 2.46-11.41), older age (OR: 1.05; 95% CI: 1.02-1.09), lower baseline @entity2 (OR: 0.92; 95% CI: 0.87-0.98), and higher brain volume receiving 25 Gy (V25Gy) (OR: 1.03; 95% CI: 1.003-1.05) as the most significant predictors for ASL. Brain V25Gy <56% appeared to be the optimal threshold (OR:  2.36; 95% CI: 1.11-5.01), with an ASL rate of 38% versus 20% above and below this threshold, respectively (P=.006). CONCLUSIONS: Female sex, older age, lower baseline @entity2 , and higher brain V25Gy are significant predictors of ASL during @entity3 + @entity5 therapy for HGG. Maintaining the V25Gy of brain below 56% may reduce the risk of ASL.

title: Clinical and Dosimetric Predictors of Acute XXXX During Radiation Therapy and Concurrent @entity4 for High-Grade @entity1 .

answer: @entity6


abstract: PURPOSE: The main drawbacks of radioimmunotherapy have been severe hematological @entity3 and potential development of @entity12 and @entity10 . Activation of @entity6 follows a major pathway by which normal tissues respond to DNA-damaging agents, such as chemotherapy and radiation therapy, that result in injuries and pathological consequences. This pathway is separate from the @entity1 suppressor pathway of @entity6 . We have previously reported that use of low-dose @entity13 (LDA) temporarily and reversibly suppresses @entity6 activation, thereby ameliorating normal tissue @entity3 from exposure to @entity7 and X rays. We have also demonstrated that LDA-mediated protection requires functional @entity6 and thus is selective to normal tissues, as essentially every @entity1 cell has dysfunctional @entity6 . Here we tested the protective efficacy of LDA for bone marrow tissue against radioimmunotherapy through animal experiments. METHODS AND MATERIALS: @entity2 were subjected to LDA pretreatment for 3  days, followed by treatment with Y-90 ibritumomab tiuxetan. Both dose course (10, 25, 50, 100, and 200   Ci) and time course (6, 24, and 72  hours and 1 and 2  weeks) experiments were performed. The response of bone marrow cells to LDA was determined by examining the expression of NFkB, @entity15 , and @entity14 . Staining with @entity8 and @entity9 , y-H2AX, and terminal deoxynucleotidyl transferase @entity11 nick end labeling (TUNEL) was used to examine morphology, DNA damage response, and apoptotic cell populations. RESULTS: Elevated levels of NFkB, @entity15 , and @entity14 were observed in bone marrow cells after LDA treatment. Bone @entity4 levels induced by Y-90 ibritumomab tiuxetan were greatly reduced by LDA pretreatment. Consistent with this observation, significantly less DNA damage and fewer apoptotic cells were accumulated after Y-90 ibritumomab tiuxetan treatment in LDA-pretreated @entity2 . Furthermore, in the @entity2 xenograft model implanted with @entity0 @entity0 @entity5 cells, LDA pretreatment did not have any detectable effect on either @entity1 growth or Y-90 ibritumomab tiuxetan (200   Ci)-induced @entity1 suppression. CONCLUSIONS: LDA pretreatment protected bone marrow without compromising @entity1 control caused by Y-90 ibritumomab tiuxetan.

title: XXXX -Based Strategy for Protection of Bone Marrow From Y-90 Ibritumomab Tiuxetan.

answer: @entity6


abstract: BACKGROUND: Studies investigating the prevention of @entity1 differ considerably in design and quality, which impedes pooling them in conventional meta-analyses, the basis for evidence-based policy making. This study is aimed at quantifying the prospective association between measured physical activity and fat mass in @entity0 , using a meta-analysis method that allows inclusion of heterogeneous studies by adjusting for differences through eliciting and incorporating expert opinion. METHODS: Studies on prevention of @entity1 using objectively measured exposure and outcome were eligible; they were adopted from a recently published systematic review. Differences in study quality and design were considered as internal and external biases and captured in checklists. Study results were converted to correlation coefficients and biases were considered either additive or proportional on this scale. The extent and uncertainty of biases in each study were elicited in a formal process by six quantitatively-trained assessors and five subject-matter specialists. Biases for each study were combined across assessors using median pooling. Results were combined across studies by random-effects meta-analysis. RESULTS: The combined correlation of the unadjusted results from the six studies was -0.04 (95%CI: -0.22, 0.14) with considerable heterogeneity (I  =78%), which makes it difficult to interpret the result. After bias-adjustment the pooled correlation was -0.01 (95%CI: -0.18, 0.16) with apparent study compatibility (I  =0%). CONCLUSION: By using this method the prospective association between physical activity and fat mass could be quantitatively synthesized; the result suggests no association. Objectively measured physical activity may not be the key determinant of unhealthy @entity1 in @entity0 .

title: Objectively measured physical activity and fat mass in XXXX : a bias-adjusted meta-analysis of prospective studies.

answer: @entity0


abstract: UNASSIGNED: @entity5 , as a primary colonizer of the tooth surface, interacts with salivary a-amylase via amylase-binding protein A (AbpA). This enzyme hydrolyzes starch to @entity0 , @entity4 , and maltodextrins that can be utilized by various oral bacteria for nutrition. Microarray studies demonstrated that AbpA modulates gene expression in response to amylase, suggesting that the amylase-streptococcal interaction may function in ways other than nutrition. The goal of this study was to explore the role of AbpA in gene regulation through comparative transcriptional profiling of wild-type KS1 and AbpA(-) mutant KS1  abpA under various environmental conditions. A portion of total RNA isolated from mid-log phase cells grown in 5% @entity2 in (1) complex medium with/without amylase, (2) defined medium (DM) containing 0.8% @entity0 with/without amylase, and (3) DM containing 0.2% @entity0 and amylase with/without starch was reverse transcribed to cDNA and the rest used for RNA-Sequencing. Changes in expression of selected genes were validated by qRT-PCR. Maltodextrin-associated genes, @entity1 synthesis genes and competence genes were differentially expressed in a medium-dependent manner. Genes in another cluster containing a putative @entity3 kinase/response regulator, peptide @entity6 reductase, thioredoxin protein, lipoprotein, and cytochrome c-type protein were downregulated in KS1  abpA under all environmental conditions tested. Thus, AbpA appears to modulate genes associated with maltodextrin utilization/transport and @entity1 synthesis. Importantly, in all growth conditions AbpA is associated with increased expression of a potential two component signaling system associated with genes involved in reducing oxidative stress suggesting a role in signal transduction and stress tolerance.

title: Dynamics of the XXXX transcriptome in response to media composition, salivary a-amylase and starch.

answer: @entity5


abstract: BACKGROUND: Lateral pelvic lymph node @entity1 is generally present in 17% of @entity0 with T3 lower @entity2 . However, such lymph node metastases cannot be accurately detected before surgery. Since 2001, we have performed sentinel node navigation surgery for @entity0 with T3 lower @entity2 considering the lymph nodes located between the @entity4 as the lateral sentinel lymph node (LSN). @entity0 AND METHODS: Between 2001 and 2010, 101 @entity0 with T3 lower @entity2 without distant @entity1 or peritoneal dissemination were prospectively enrolled in the study. @entity0 with negative lymph nodes in the mesorectum underwent only LSN dissection in the lateral pelvic space. @entity0 with metastatic lymph nodes detected in the mesorectum underwent lateral pelvic lymph node dissection (LPLD). RESULTS: Fifty-three out of the 101 @entity0 with pathologically-negative lymph nodes in the mesorectum and a negative LSN were clinically judged as having @entity3 because no recurrence was detected in the lateral pelvic space during the three years following surgery. The other 48 @entity0 underwent LPLD because of a positive lymph node in the mesorectum, and were further divided into two sub-groups, 40 with a negative and 8 with a positive LSN. Only the eight @entity0 with a positive LSN also had positive lymph nodes in the lateral pelvic space. CONCLUSION: @entity0 with T3 lower @entity2 in stage III may not require LPLD. LSN may be very useful to determine @entity3 during surgery.

title: Sentinel node navigation surgery for lower XXXX .

answer: @entity2


abstract: Context     Many @entity0 with musculoskeletal issues seek traditional Korean medicine or complementary and alternative medicine (CAM) to treat or help deal with their health conditions. Practitioners and @entity0 should be aware of diseases that can exhibit similar symptoms, consequently complicating diagnosis and treatment. Objective     The study intended to examine a case of @entity9 ( @entity9 ), in which the @entity0 presented with @entity5 , @entity1 , and weakness that gave cause for diagnostic error at onset. Design     The research team has reported a case study. Setting     The study was conducted at Jaseng Hospital of Korean Medicine in Seoul, Korea. @entity0     After initially being prescribed back surgery for lumbar disc herniation, as confirmed by lumbar magnetic resonance imaging (MRI) at a previous hospital, a 54-y-old female with @entity6 as her chief complaint chose to transfer to a Korean medicine hospital for nonsurgical treatment. Intervention     The @entity0 became nonambulatory owing to a sudden decrease in muscle strength during admission and underwent a cervical MRI to assess for cervical @entity3 because she developed @entity8 and @entity7 . She then was diagnosed with @entity9 and received a regime of symptomatic treatment with CAM, including acupuncture, electroacupuncture, pharmacopuncture, and herbal medicine. Results     The cervical MRI results showed that the symptoms were not due to @entity3 or @entity4 , and @entity9 was suspected because of the progressive ascending weakness, absence of myotatic reflexes in the lower limbs, and preceding flu-like symptoms. The @entity0 showed @entity2 recuperation after the CAM treatments, recovering motor strength and ambulation. Conclusions     A seemingly typical @entity0 with musculoskeletal symptoms may turn out to have a completely different pathology, and clinicians should keep such potential confounders and comorbidities in mind when diagnosing @entity0 .

title: XXXX mistaken for a common spinal disorder: a case report.

answer: @entity9


abstract: INTRODUCTION: Telehealth has been widely promoted as a technology to make healthcare more effective and affordable. However, current telehealth systems suffer from vendor lock-in and high cost, and are designed for managing @entity1 rather than preventing them. METHODS: We address shortcomings of existing consumer-level health informatics applications in supporting senior health consumers, and provide designers of such systems with a design framework. We assess the feasibility of @entity0 -centred health management systems (HMSs) that are designed based on the proposed framework. In contrast to traditional telehealth, HMSs are @entity0 centred and aim at enabling health consumers to take control of their own health by providing functionality for health self-management. Quantitative and qualitative methods were adopted in evaluating a @entity2 . RESULTS: Senior healthcare consumers viewed our @entity2 prototype positively, and experienced a positive change in their attitude towards their health. We identified requirements and challenges for HMSs. In particular, @entity0 indicated that social networking features must have a clear purpose beyond simple broadcasting of emotions and opinions. DISCUSSION: Our study indicates that seniors are able and motivated to leverage a web-based @entity0 -centred @entity2 , provided that there are suitable health support applications tailored to their needs. This could be achieved by making it attractive for third party application developers to contribute @entity2 content.

title: Designing and evaluating a XXXX -centred health management system for seniors.

answer: @entity0


abstract: INTRODUCTION: 'Store and forward' teledermoscopy is a technology with potential advantages for @entity1 screening. Any large-scale implementation of this technology is dependent on consumer acceptance. AIM: To investigate preferences for @entity1 screening options compared with skin self-examination in adults considered to be at increased risk of developing @entity2 . METHODS: A discrete choice experiment was completed by 35 consumers, all of whom had prior experience with the use of teledermoscopy, in Queensland, Australia. @entity0 made 12 choices between screening alternatives described by seven attributes including monetary cost. A mixed logit model was used to estimate the relative weights that consumers place on different aspects of screening, along with the marginal willingness to pay for teledermoscopy as opposed to screening at a clinic. RESULTS: Overall, @entity0 preferred screening/diagnosis by a health professional rather than skin self-examination. Key drivers of screening choice were for results to be reviewed by a dermatologist; a higher detection rate; fewer non-cancerous moles being removed in relation to every @entity2 detected; and less time spent away from usual activities. On average, @entity0 were willing to pay AUD110 to have teledermoscopy with dermatologist review available to them as a screening option. DISCUSSION AND CONCLUSIONS: Consumers preferentially value aspects of care that are more feasible with a teledermoscopy screening model, as compared with other @entity2 screening and diagnosis options. This study adds to previous literature in the area which has relied on the use of consumer satisfaction scales to assess the acceptability of teledermoscopy.

title: Consumer preferences for teledermoscopy screening to detect XXXX early.

answer: @entity1


abstract: PURPOSE: This multicenter, randomized trial compared @entity2 plus @entity4 (XELOX) with bolus @entity5 (FU) and @entity6 (FA) as adjuvant therapy for @entity0 with @entity1 . @entity0 AND METHODS: @entity0 who had undergone curative resection were randomly assigned to XELOX ( @entity4 130 mg/m(2) on day 1 plus @entity2 1,000 mg/m(2) twice daily on days 1 to 14 every 3 weeks for 24 weeks) or a standard bolus FU/FA adjuvant regimen (Mayo Clinic for 24 weeks or Roswell Park for 32 weeks). The primary study end point was disease-free survival (DFS). RESULTS: The intention-to-treat population comprised 1,886 @entity0 ; 944 @entity0 were randomly assigned to XELOX and 942 to FU/FA (Mayo Clinic, n = 664; Roswell Park, n = 278). After 57 months of follow-up for the primary analysis, 295 @entity0 (31.3%) in the XELOX group had relapsed, developed a new primary @entity3 , or died compared with 353 @entity0 (37.5%) in the FU/FA group (hazard ratio [HR] for DFS, 0.80; 95% CI, 0.69 to 0.93; P = .0045). The 3-year DFS rate was 70.9% with XELOX and 66.5% with FU/FA. The HR for overall survival (OS) for XELOX compared to FU/FA was 0.87 (95% CI, 0.72 to 1.05; P = .1486). The 5-year OS for XELOX and FU/FA were 77.6% and 74.2%, respectively. Follow-up is ongoing. Preplanned multivariate and subgroup analyses supported the robustness of these findings. CONCLUSION: The addition of @entity4 to @entity2 improves DFS in @entity0 with @entity1 . XELOX is an additional adjuvant treatment option for these @entity0 .

title: @entity2 plus XXXX compared with @entity5 and @entity6 as adjuvant therapy for @entity1 .

answer: @entity4


abstract: PURPOSE: This multicenter, randomized trial compared @entity2 plus @entity4 (XELOX) with bolus @entity5 (FU) and @entity6 (FA) as adjuvant therapy for @entity0 with @entity1 . @entity0 AND METHODS: @entity0 who had undergone curative resection were randomly assigned to XELOX ( @entity4 130 mg/m(2) on day 1 plus @entity2 1,000 mg/m(2) twice daily on days 1 to 14 every 3 weeks for 24 weeks) or a standard bolus FU/FA adjuvant regimen (Mayo Clinic for 24 weeks or Roswell Park for 32 weeks). The primary study end point was disease-free survival (DFS). RESULTS: The intention-to-treat population comprised 1,886 @entity0 ; 944 @entity0 were randomly assigned to XELOX and 942 to FU/FA (Mayo Clinic, n = 664; Roswell Park, n = 278). After 57 months of follow-up for the primary analysis, 295 @entity0 (31.3%) in the XELOX group had relapsed, developed a new primary @entity3 , or died compared with 353 @entity0 (37.5%) in the FU/FA group (hazard ratio [HR] for DFS, 0.80; 95% CI, 0.69 to 0.93; P = .0045). The 3-year DFS rate was 70.9% with XELOX and 66.5% with FU/FA. The HR for overall survival (OS) for XELOX compared to FU/FA was 0.87 (95% CI, 0.72 to 1.05; P = .1486). The 5-year OS for XELOX and FU/FA were 77.6% and 74.2%, respectively. Follow-up is ongoing. Preplanned multivariate and subgroup analyses supported the robustness of these findings. CONCLUSION: The addition of @entity4 to @entity2 improves DFS in @entity0 with @entity1 . XELOX is an additional adjuvant treatment option for these @entity0 .

title: @entity2 plus @entity4 compared with @entity5 and XXXX as adjuvant therapy for @entity1 .

answer: @entity6


abstract: PURPOSE: This multicenter, randomized trial compared @entity2 plus @entity4 (XELOX) with bolus @entity5 (FU) and @entity6 (FA) as adjuvant therapy for @entity0 with @entity1 . @entity0 AND METHODS: @entity0 who had undergone curative resection were randomly assigned to XELOX ( @entity4 130 mg/m(2) on day 1 plus @entity2 1,000 mg/m(2) twice daily on days 1 to 14 every 3 weeks for 24 weeks) or a standard bolus FU/FA adjuvant regimen (Mayo Clinic for 24 weeks or Roswell Park for 32 weeks). The primary study end point was disease-free survival (DFS). RESULTS: The intention-to-treat population comprised 1,886 @entity0 ; 944 @entity0 were randomly assigned to XELOX and 942 to FU/FA (Mayo Clinic, n = 664; Roswell Park, n = 278). After 57 months of follow-up for the primary analysis, 295 @entity0 (31.3%) in the XELOX group had relapsed, developed a new primary @entity3 , or died compared with 353 @entity0 (37.5%) in the FU/FA group (hazard ratio [HR] for DFS, 0.80; 95% CI, 0.69 to 0.93; P = .0045). The 3-year DFS rate was 70.9% with XELOX and 66.5% with FU/FA. The HR for overall survival (OS) for XELOX compared to FU/FA was 0.87 (95% CI, 0.72 to 1.05; P = .1486). The 5-year OS for XELOX and FU/FA were 77.6% and 74.2%, respectively. Follow-up is ongoing. Preplanned multivariate and subgroup analyses supported the robustness of these findings. CONCLUSION: The addition of @entity4 to @entity2 improves DFS in @entity0 with @entity1 . XELOX is an additional adjuvant treatment option for these @entity0 .

title: @entity2 plus @entity4 compared with XXXX and @entity6 as adjuvant therapy for @entity1 .

answer: @entity5


abstract: PURPOSE: This multicenter, randomized trial compared @entity2 plus @entity4 (XELOX) with bolus @entity5 (FU) and @entity6 (FA) as adjuvant therapy for @entity0 with @entity1 . @entity0 AND METHODS: @entity0 who had undergone curative resection were randomly assigned to XELOX ( @entity4 130 mg/m(2) on day 1 plus @entity2 1,000 mg/m(2) twice daily on days 1 to 14 every 3 weeks for 24 weeks) or a standard bolus FU/FA adjuvant regimen (Mayo Clinic for 24 weeks or Roswell Park for 32 weeks). The primary study end point was disease-free survival (DFS). RESULTS: The intention-to-treat population comprised 1,886 @entity0 ; 944 @entity0 were randomly assigned to XELOX and 942 to FU/FA (Mayo Clinic, n = 664; Roswell Park, n = 278). After 57 months of follow-up for the primary analysis, 295 @entity0 (31.3%) in the XELOX group had relapsed, developed a new primary @entity3 , or died compared with 353 @entity0 (37.5%) in the FU/FA group (hazard ratio [HR] for DFS, 0.80; 95% CI, 0.69 to 0.93; P = .0045). The 3-year DFS rate was 70.9% with XELOX and 66.5% with FU/FA. The HR for overall survival (OS) for XELOX compared to FU/FA was 0.87 (95% CI, 0.72 to 1.05; P = .1486). The 5-year OS for XELOX and FU/FA were 77.6% and 74.2%, respectively. Follow-up is ongoing. Preplanned multivariate and subgroup analyses supported the robustness of these findings. CONCLUSION: The addition of @entity4 to @entity2 improves DFS in @entity0 with @entity1 . XELOX is an additional adjuvant treatment option for these @entity0 .

title: XXXX plus @entity4 compared with @entity5 and @entity6 as adjuvant therapy for @entity1 .

answer: @entity2


abstract: PURPOSE: This multicenter, randomized trial compared @entity2 plus @entity4 (XELOX) with bolus @entity5 (FU) and @entity6 (FA) as adjuvant therapy for @entity0 with @entity1 . @entity0 AND METHODS: @entity0 who had undergone curative resection were randomly assigned to XELOX ( @entity4 130 mg/m(2) on day 1 plus @entity2 1,000 mg/m(2) twice daily on days 1 to 14 every 3 weeks for 24 weeks) or a standard bolus FU/FA adjuvant regimen (Mayo Clinic for 24 weeks or Roswell Park for 32 weeks). The primary study end point was disease-free survival (DFS). RESULTS: The intention-to-treat population comprised 1,886 @entity0 ; 944 @entity0 were randomly assigned to XELOX and 942 to FU/FA (Mayo Clinic, n = 664; Roswell Park, n = 278). After 57 months of follow-up for the primary analysis, 295 @entity0 (31.3%) in the XELOX group had relapsed, developed a new primary @entity3 , or died compared with 353 @entity0 (37.5%) in the FU/FA group (hazard ratio [HR] for DFS, 0.80; 95% CI, 0.69 to 0.93; P = .0045). The 3-year DFS rate was 70.9% with XELOX and 66.5% with FU/FA. The HR for overall survival (OS) for XELOX compared to FU/FA was 0.87 (95% CI, 0.72 to 1.05; P = .1486). The 5-year OS for XELOX and FU/FA were 77.6% and 74.2%, respectively. Follow-up is ongoing. Preplanned multivariate and subgroup analyses supported the robustness of these findings. CONCLUSION: The addition of @entity4 to @entity2 improves DFS in @entity0 with @entity1 . XELOX is an additional adjuvant treatment option for these @entity0 .

title: @entity2 plus @entity4 compared with @entity5 and @entity6 as adjuvant therapy for XXXX .

answer: @entity1


abstract: OBJECTIVE: To determine the feasibility of genotyping @entity2 via fine needle aspirates (FNAs). BACKGROUND: FNA is a common method of diagnosis for @entity2 , yet it has traditionally been considered inadequate for molecular studies due to the limited quantity of DNA derived from FNA specimens and @entity1 heterogeneity. METHODS: In vitro mixing studies were performed to deduce the minimum cellularity needed for genetic analysis. DNA from both simulated FNAs and clinical FNAs was sequenced. Mutational concordance was determined between simulated FNAs and that of the resected specimen. RESULTS: Limiting dilution studies indicated that mutations present at allele frequencies as low as 0.12% are detectable. Comparison of simulated FNAs and matched @entity1 tissue exhibited a concordance frequency of 100% for all driver genes present. In FNAs obtained from 17 @entity0 with unresectable disease, we identified at least 1 driver gene mutation in all @entity0 including actionable somatic mutations in @entity3 and @entity4 . The constellation of mutations identified in these @entity0 was different than that reported for resectable @entity2 , implying a biologic basis for presentation with locally advanced @entity2 . CONCLUSIONS: FNA sequencing is feasible and subsets of @entity0 may harbor actionable mutations that could potentially impact therapy. Moreover, preoperative FNA sequencing has the potential to influence the timing of surgery relative to systemic therapy. FNA sequencing opens the door to clinical trials in which @entity0 undergo neoadjuvant or a surgery-first approach based on their @entity1 genetics with the goal of utilizing @entity1 genomics in the clinical management of @entity2 .

title: Reliable Detection of Somatic Mutations in Fine Needle Aspirates of XXXX With Next-generation Sequencing: Implications for Surgical Management.

answer: @entity2


abstract: AIM: To investigate the blood pressure (BP) reaction to public speaking performed according to different emotionally distressing scenarios in stage 1 @entity0 . METHODS. We assessed 64 @entity0 and 30 normotensive subjects. They performed three speech tasks with neutral, anger and @entity1 scenarios. BP was assessed with the Finometer beat-to-beat non-invasive recording system throughout the test procedure. RESULTS: For all types of speech, the systolic BP response was greater in the @entity0 than the normotensive subjects (all p < 0.001). At repeated-measures analysis of covariate (R-M ANCOVA), a significant group-by-time interaction was found for all scenarios (p  <= 0.001). For the diastolic BP response, the between-group difference was significant for the task with @entity1 scenario (p < 0.05). At R-M ANCOVA, a group-by-time interaction of borderline statistical significance was found for the speech with @entity1 content (p = 0.053) but not for the speeches with neutral or anger content. Within the @entity0 group, the diastolic BP increments during the speeches with @entity1 and anger scenarios were greater than those during the speech with neutral scenario (both p < 0.001). CONCLUSIONS: These data indicate that reactivity to public speaking is increased in stage 1 @entity0 . A speech with @entity1 or anger scenario elicits a greater diastolic BP reaction than tasks with neutral content.

title: BP reactivity to public speaking in stage 1 XXXX : influence of different task scenarios.

answer: @entity0


abstract: The Beef Improvement Federation recommends residual feed intake (RFI) be calculated from 70-d tests preceded by a 21-d adjustment period. Individual animal feed intake and gain measurements are expensive and time consuming, which limits the number of animals available for national genetic evaluation of feed intake. If a shorter test period of comparable accuracy could be used, the cost would decrease and more animals could be tested annually. The objective of this study was to determine if data from shortened tests is equally as predictive of average daily @entity2 (ADMI) and RFI values from 70-d tests. Feed intake and weight measures were collected after weaning from @entity1 bulls, steers, and heifers (n = 612) during four 70-d performance tests. For each individual, ADMI and RFI were calculated. Residual feed intake was calculated by regressing ADMI on @entity0 ( @entity0 ) and ADG with the effect of breed included where appropriate. Based on four 70-d intake tests, ADMI, RFI, ADG, and @entity0 were evaluated using shortened test lengths in a post hoc analysis where shortened test lengths were imposed on the full-period tests. The ADMI, RFI, ADG, and @entity0 values from the full 70-d test were regressed on ADMI, RFI, ADG, and @entity0 values resulting from the constructed shorter data subsets. The 8 subsets ranged from 14 to 56 d in length. The fixed effects of test, breed, animal's origin, and sex were included in each comparison for ADMI, ADG, and @entity0 . Estimates for regression coefficients of ADMI values from a full test on various subsets ranged from 0.63 to 1.02. Likewise, estimated coefficients obtained from the regression of full test RFI, ADG, and @entity0 values on subsets ranged from 0.50 to 1.00, 0.09 to 0.85, and 0.48 to 1.02, respectively. We conclude that ADMI values from a 42-d test ( < 0.0001) and RFI values from a 56-d test (P < 0.0001) adequately predict ADMI and RFI when compared to a 70-d test. These results suggest that testing periods of 42 d for determining ADMI and 56 d for RFI could ultimately reduce testing costs and result in collection of data on a larger number of animals per year, in turn resulting in more data for genetic evaluation.

title: Optimum measurement period for evaluating feed intake traits in beef XXXX .

answer: @entity1


abstract: Emerging evidence indicates that @entity4 ( @entity4 ) is associated with a wide variety of extrahepatic complications. However, the potential association between @entity1 and @entity4 has been less investigated. This study examined the relationship between pulmonary function and @entity3 in 9976 adults participating in a cross-sectional analysis of the Third National Health and Nutrition Examination Survey (NHANES III). @entity4 was defined as @entity3 presented on ultrasound examinations in the absence of other known @entity2 . The associations between predicted forced expiratory volume in 1 second (FEV1)% or predicted forced vital capacity (FVC)% and @entity4 were examined using multivariable linear regression while controlling for confounders. The association between obstructive or restrictive spirometry patterns and @entity4 was also evaluated using multivariable logistic regression analysis. After adjustment for multiple covariates, predicted FEV1% and FVC% were significantly and inversely associated with the degree of @entity3 (P for trend <0.001 for both). The restrictive lung pattern was significantly related to @entity0 with moderate and severe @entity3 as compared with those without @entity3 (OR 1.65, 95% CI 1.14-2.39 and OR 1.85, 95% CI 1.13-2.82), whereas the obstructive lung pattern was not associated with the presence of @entity3 . Individuals with a greater degree of @entity3 were at greater risk for poor pulmonary function, especially in restrictive pattern. These novel findings demonstrate that @entity1 is also an extrahepatic complication of @entity4 .

title: Association Between Pulmonary Function and Nonalcoholic Fatty XXXX in the NHANES III Study.

answer: @entity2


abstract: UNASSIGNED: Purpose To assess the sensitivity and specificity for ratios of adrenal vein @entity1 level ( @entity4 ) to peripheral vein @entity1 level (Cp), adrenal vein @entity2 level (Aa) to peripheral vein @entity2 level (Ap), and combined @entity1 and @entity2 levels ("combined ratio") for the detection of successful adrenal vein catheterization ("selectivity") in adrenal vein sampling (AVS) without @entity3 (ACTH) injection at different cutoff values. Materials and Methods This retrospective study was approved by the institutional review board, and informed consent was waived. AVS was performed in 160 consecutive @entity0 (49 @entity0 and 111 @entity0 ; mean age, 53.6 years) between December 1989 and January 2014. @entity1 and @entity2 levels were measured in samples from the adrenal veins and left iliac vein every 5 minutes, two times before (basal) and three times after intravenous cosyntropin (ACTH 1-24) injection. Selectivity was defined by @entity4 /Cp or Aa/Ap ratio of at least 5 in at least one sampling after ACTH administration. Sensitivity and specificity for the detection of selective adrenal vein catheterization were calculated for basal @entity4 /Cp ratio, Aa/Ap ratio, and combined ratios for three cutoff values reported in the literature. The McNemar test was used to assess differences in sensitivity and specificity to detect selective adrenal vein catheterization. Results The sensitivity and specificity for the cutoff values of at least 3, at least 2, and at least 1.1 for the detection of AVS selectivity were respectively 50.4% and 100%, 70.8% and 100%, and 98.5% and 76.9% for @entity4 /Cp ratio; 61.3% and 100%, 70.8% and 100%, and 94.2% and 53.8% for Aa/Ap ratio; and 75.2% and 100%, 88.3% and 100%, and 99.3% and 46.2% for combined ratios (sensitivity at the >= 2 cutoff value: P < .0001 for combined ratio vs @entity4 /Cp ratio and for combined ratio vs Aa/Ap ratio). Conclusion Basal combined ratio has the best sensitivity for the detection of AVS selectivity at all cutoff values, and for all ratios, the cutoff value of at least 2 has the best sensitivity for 100% specificity. (  ) RSNA, 2015.

title: Adrenal Vein Sampling in Primary Aldosteronism: Sensitivity and Specificity of Basal Adrenal Vein to Peripheral Vein XXXX and @entity2 Ratios to Confirm Catheterization of the Adrenal Vein.

answer: @entity1


abstract: UNASSIGNED: Purpose To assess the sensitivity and specificity for ratios of adrenal vein @entity1 level ( @entity4 ) to peripheral vein @entity1 level (Cp), adrenal vein @entity2 level (Aa) to peripheral vein @entity2 level (Ap), and combined @entity1 and @entity2 levels ("combined ratio") for the detection of successful adrenal vein catheterization ("selectivity") in adrenal vein sampling (AVS) without @entity3 (ACTH) injection at different cutoff values. Materials and Methods This retrospective study was approved by the institutional review board, and informed consent was waived. AVS was performed in 160 consecutive @entity0 (49 @entity0 and 111 @entity0 ; mean age, 53.6 years) between December 1989 and January 2014. @entity1 and @entity2 levels were measured in samples from the adrenal veins and left iliac vein every 5 minutes, two times before (basal) and three times after intravenous cosyntropin (ACTH 1-24) injection. Selectivity was defined by @entity4 /Cp or Aa/Ap ratio of at least 5 in at least one sampling after ACTH administration. Sensitivity and specificity for the detection of selective adrenal vein catheterization were calculated for basal @entity4 /Cp ratio, Aa/Ap ratio, and combined ratios for three cutoff values reported in the literature. The McNemar test was used to assess differences in sensitivity and specificity to detect selective adrenal vein catheterization. Results The sensitivity and specificity for the cutoff values of at least 3, at least 2, and at least 1.1 for the detection of AVS selectivity were respectively 50.4% and 100%, 70.8% and 100%, and 98.5% and 76.9% for @entity4 /Cp ratio; 61.3% and 100%, 70.8% and 100%, and 94.2% and 53.8% for Aa/Ap ratio; and 75.2% and 100%, 88.3% and 100%, and 99.3% and 46.2% for combined ratios (sensitivity at the >= 2 cutoff value: P < .0001 for combined ratio vs @entity4 /Cp ratio and for combined ratio vs Aa/Ap ratio). Conclusion Basal combined ratio has the best sensitivity for the detection of AVS selectivity at all cutoff values, and for all ratios, the cutoff value of at least 2 has the best sensitivity for 100% specificity. (  ) RSNA, 2015.

title: Adrenal Vein Sampling in Primary Aldosteronism: Sensitivity and Specificity of Basal Adrenal Vein to Peripheral Vein @entity1 and XXXX Ratios to Confirm Catheterization of the Adrenal Vein.

answer: @entity2


abstract: We analyzed the changes of post-movement beta synchronization (PMBS) of the electroencephalogram (EEG) in @entity4 with @entity1 . Our aim was to determine if PMBS in @entity4 is altered in a different way than in @entity2 or in essential @entity3 . Our purpose was to find out whether the analysis of PMBS could help the diagnosis in ambiguous cases. Ten @entity0 with @entity1 of @entity4 and ten controls performed self-paced movements with the dominant hand during EEG acquisition. Five electrodes above the sensorimotor cortex were selected for evaluation (C3, C1, Cz, C2, C4) as contralateral (C); contralateral medial (CM); medial (M); ipsilateral medial (IM); ipsilateral (I) relative to the dominant hand. Power and latency of PMBS were calculated by time resolved power spectral analysis with multitaper method. PMBS power in the C electrode position was significantly lower in @entity0 than in controls, its contralateral preponderance disappeared in the @entity0 group. In every location, latency of PMBS was significantly longer in the Wilson group compared to controls. More altered PMBS could be measured in @entity0 with both basal ganglia and cerebellar involvements. Since decreased power of PMBS was observed in @entity2 and increased latency in essential @entity3 , the combined change of PMBS can indicate pathology of different neural circuits and may help the diagnosis in challenging cases.

title: Disturbed post-movement beta synchronization in @entity4 with XXXX .

answer: @entity1


abstract: We analyzed the changes of post-movement beta synchronization (PMBS) of the electroencephalogram (EEG) in @entity4 with @entity1 . Our aim was to determine if PMBS in @entity4 is altered in a different way than in @entity2 or in essential @entity3 . Our purpose was to find out whether the analysis of PMBS could help the diagnosis in ambiguous cases. Ten @entity0 with @entity1 of @entity4 and ten controls performed self-paced movements with the dominant hand during EEG acquisition. Five electrodes above the sensorimotor cortex were selected for evaluation (C3, C1, Cz, C2, C4) as contralateral (C); contralateral medial (CM); medial (M); ipsilateral medial (IM); ipsilateral (I) relative to the dominant hand. Power and latency of PMBS were calculated by time resolved power spectral analysis with multitaper method. PMBS power in the C electrode position was significantly lower in @entity0 than in controls, its contralateral preponderance disappeared in the @entity0 group. In every location, latency of PMBS was significantly longer in the Wilson group compared to controls. More altered PMBS could be measured in @entity0 with both basal ganglia and cerebellar involvements. Since decreased power of PMBS was observed in @entity2 and increased latency in essential @entity3 , the combined change of PMBS can indicate pathology of different neural circuits and may help the diagnosis in challenging cases.

title: Disturbed post-movement beta synchronization in XXXX with @entity1 .

answer: @entity4


abstract: PURPOSE: To investigate the acute effects of @entity2 on the anterior chamber angle (ACA) and @entity4 in @entity0 with @entity3 . METHODS: This prospective study included 15 eyes of 15 @entity0 with @entity3 who have been scheduled to start @entity2 therapy. All @entity0 underwent complete ophthalmic examination including measurement of the ACA and @entity4 using a spectral domain optical coherence tomography device (Optovue Inc.) and refractive status evaluation with an autorefractokeratometer (KR-8100; Topcon) at the baseline and 1 week after starting therapy. The @entity0 were asked to report any @entity1 or discomfort in their eyes during therapy at the follow-up visit. RESULTS: None of the @entity0 experienced @entity1 or discomfort in their eyes. The mean ACA significantly decreased at the first week of the therapy compared with the baseline levels (40.34  7.06   and 36.89  6.87  , respectively) (P=0.001). However, the mean @entity4 increased from 277.33  95.60  m at the baseline to 323.40  84.50  m at the first week (P=0.01). There was a nonsignificant increase in the mean refractive error (from -0.25  0.54 diopter [D] at the baseline to -0.38  0.49 D after 1 week) (P=0.06). CONCLUSIONS: @entity2 can acutely decrease the ACA and increase the @entity4 . Because these effects may be asymptomatic, @entity0 with @entity3 who start this therapy should be warned to be closely followed up by an ophthalmologist.

title: @entity2 -Induced Changes in Anterior Chamber Angle and XXXX .

answer: @entity4


abstract: PURPOSE: To investigate the acute effects of @entity2 on the anterior chamber angle (ACA) and @entity4 in @entity0 with @entity3 . METHODS: This prospective study included 15 eyes of 15 @entity0 with @entity3 who have been scheduled to start @entity2 therapy. All @entity0 underwent complete ophthalmic examination including measurement of the ACA and @entity4 using a spectral domain optical coherence tomography device (Optovue Inc.) and refractive status evaluation with an autorefractokeratometer (KR-8100; Topcon) at the baseline and 1 week after starting therapy. The @entity0 were asked to report any @entity1 or discomfort in their eyes during therapy at the follow-up visit. RESULTS: None of the @entity0 experienced @entity1 or discomfort in their eyes. The mean ACA significantly decreased at the first week of the therapy compared with the baseline levels (40.34  7.06   and 36.89  6.87  , respectively) (P=0.001). However, the mean @entity4 increased from 277.33  95.60  m at the baseline to 323.40  84.50  m at the first week (P=0.01). There was a nonsignificant increase in the mean refractive error (from -0.25  0.54 diopter [D] at the baseline to -0.38  0.49 D after 1 week) (P=0.06). CONCLUSIONS: @entity2 can acutely decrease the ACA and increase the @entity4 . Because these effects may be asymptomatic, @entity0 with @entity3 who start this therapy should be warned to be closely followed up by an ophthalmologist.

title: XXXX -Induced Changes in Anterior Chamber Angle and @entity4 .

answer: @entity2


abstract: BACKGROUND: Growth factor technologies are increasingly used to enhance healing in @entity1 , particularly in sports medicine. Two such products; platelet-rich plasma (PRP) and autologous blood, have a growing body of supporting evidence. No previous trial has directly compared the efficacy of these two methods. HYPOTHESIS: Growth factor administration improves tissue regeneration in @entity0 who have failed to respond to conservative therapy. STUDY DESIGN: A prospective, double-blind, randomised trial. METHODS: Elbow @entity3 @entity0 who had failed conservative physical therapy were divided into two @entity0 groups: PRP injection (N=80) and autologous blood injection (ABI) (N=70). Each @entity0 received two injections at 0 and 1 month. @entity0 -related @entity4 (PRTEE) was recorded by a blinded investigator at 0, 1, 3 and 6 months. The main outcome measure was PRTEE, a validated composite outcome for @entity2 , activities of daily living and physical function, utilising a 0-100 scale. RESULTS: At 6 months the authors observed a 66% success rate in the PRP group versus 72% in the ABI group, p=NS. There was a higher rate of conversion to surgery in the ABI group (20%) versus the PRP group (10%). CONCLUSION: In @entity0 who are resistant to first-line physical therapy such as eccentric loading, ABI or PRP injections are useful second-line therapies to improve clinical outcomes. In this study, up to seven out of 10 additional @entity0 in this difficult to treat cohort benefit from a surgery-sparing intervention.

title: Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow XXXX : a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections.

answer: @entity3


abstract: INTRODUCTION: Health staff self-applied strategies are insufficiently to reduce cardiovascular risk factors. The aim of this article is to investigate the prevalence of @entity7 , @entity1 and @entity3 and waist/height index on health staff. METHODS: This is a cross-sectional study from January to April 2014 in 735 workers of the UMAE Specialties La Raza. A diagnosis of @entity7 and @entity1 was established according to WHO criteria and @entity3 NCEP @entity5 -III. In 250 @entity0 lipid profile and blood chemistry were obtained. Descriptive statistics was applied, chi square, Student t test or Kruskal-Wallis to compare groups. RESULTS: We included 496 @entity0 and 239 @entity0 (physicians, nurses and other workers). 38% were @entity7 ; 22% had @entity1 . We found fasting @entity8 >126 mg/dl in 5.1%, between 100-126 mg/dl in 17.4%, @entity6 in 40.4%; HDL @entity2 <40 mg/dl 66% in @entity0 and HDL @entity2 <50 mg/dl 51.4% in @entity0 . Waist measurement was 93  11 cm in @entity0 vs. 88  13 m in @entity0 . The waist/height index in the ideal weight group was 0.048  0.04, for @entity7 0.55  0.04 and for @entity1 0.65  0.064 (p<0.01). @entity3 prevalence was 30.6%, smoking 21.6% and @entity4 consumption 35%. CONCLUSIONS: The prevalence of @entity1 - @entity7 was 60% and @entity3 30%, making it necessary to take immediate actions to modify the lifestyle of health staff.

title: [Overweigth, XXXX , @entity3 and waist/height index in health staff].

answer: @entity1


abstract: INTRODUCTION: Health staff self-applied strategies are insufficiently to reduce cardiovascular risk factors. The aim of this article is to investigate the prevalence of @entity7 , @entity1 and @entity3 and waist/height index on health staff. METHODS: This is a cross-sectional study from January to April 2014 in 735 workers of the UMAE Specialties La Raza. A diagnosis of @entity7 and @entity1 was established according to WHO criteria and @entity3 NCEP @entity5 -III. In 250 @entity0 lipid profile and blood chemistry were obtained. Descriptive statistics was applied, chi square, Student t test or Kruskal-Wallis to compare groups. RESULTS: We included 496 @entity0 and 239 @entity0 (physicians, nurses and other workers). 38% were @entity7 ; 22% had @entity1 . We found fasting @entity8 >126 mg/dl in 5.1%, between 100-126 mg/dl in 17.4%, @entity6 in 40.4%; HDL @entity2 <40 mg/dl 66% in @entity0 and HDL @entity2 <50 mg/dl 51.4% in @entity0 . Waist measurement was 93  11 cm in @entity0 vs. 88  13 m in @entity0 . The waist/height index in the ideal weight group was 0.048  0.04, for @entity7 0.55  0.04 and for @entity1 0.65  0.064 (p<0.01). @entity3 prevalence was 30.6%, smoking 21.6% and @entity4 consumption 35%. CONCLUSIONS: The prevalence of @entity1 - @entity7 was 60% and @entity3 30%, making it necessary to take immediate actions to modify the lifestyle of health staff.

title: [Overweigth, @entity1 , XXXX and waist/height index in health staff].

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) is characterized by stereotyped repetitive, @entity1 , referred as an electric shock, triggered by the stimulation of the rami of the trigeminy nerve. It presents more frequently in @entity0 . The aim is to know the efficacy of surgical treatment of @entity2 against @entity1 by means of microvascular decompressive technics (MDT) and balloon percutaneous microcompression (BPM). METHODS: A retrospective study was performed from January 2005 to January 2013, including 73 @entity0 treated for @entity2 . Sixty @entity0 from group 1 (82 %) were treated with MDT, and 13 from group 2 with BPM. We evaluated the presence of @entity1 in @entity0 during the immediate postoperative period, and at 1, 3 and 5 years. RESULTS: 55 female @entity0 and 18 male @entity0 were included. The mean age of presentation for @entity2 was 55 years. In group 1 there was @entity1 remission in the immediate postoperative period in 95% of the cases, in 92% at one year, 91% at 3 years and 88% at 5 years; in group 2 in 85%, 84%, 84% and 70%, respectively. There were no lethal complications in 6.5% in group 1 and in 28% in group 2. CONCLUSIONS: The two therapeutic procedures reduced @entity1 of @entity2 in a long term in most @entity0 . Our results show high and perdurable resolution of the @entity1 with negligible morbimortality.

title: [Invasive management of XXXX . 8 years experience].

answer: @entity2


abstract: Purpose:To retrospectively determine the relationship between apparent diffusion coefficients (ADCs) obtained with 3.0-T diffusion-weighted (DW) magnetic resonance (MR) imaging and Gleason grades in @entity2 .Materials and Methods:The requirement to obtain institutional review board approval was waived. Fifty-one @entity0 with @entity2 underwent MR imaging before prostatectomy, including DW MR imaging with b values of 0, 50, 500, and 800 sec/mm(2). In prostatectomy specimens, separate slice-by-slice determinations of Gleason grade groups were performed according to primary, secondary, and tertiary Gleason grades. In addition, @entity1 were classified into qualitative grade groups (low-, intermediate-, or high-grade @entity1 ). ADC maps were aligned to step-sections and regions of interest annotated for each @entity1 slice. The median ADC of @entity1 was related to qualitative grade groups with linear mixed-model regression analysis. The accuracy of the median ADC in the most aggressive @entity1 component in the differentiation of low- from combined intermediate- and high-grade @entity1 was summarized by using the area under the receiver operating characteristic (ROC) curve (A(z)).Results:In 51 prostatectomy specimens, 62 different @entity1 and 251 step-section @entity1 lesions were identified. The median ADC in the @entity1 showed a negative relationship with Gleason grade group, and differences among the three qualitative grade groups were statistically significant (P < .001). Overall, with an increase of one qualitative grade group, the median ADC (  standard deviation) decreased 0.18   10(-3) mm(2)/sec    0.02. Low-, intermediate-, and high-grade @entity1 had a median ADC of 1.30   10(-3) mm(2)/sec    0.30, 1.07   10(-3) mm(2)/sec    0.30, and 0.94   10(-3) mm(2)/sec    0.30, respectively. ROC analysis showed a discriminatory performance of A(z) = 0.90 in discerning low-grade from combined intermediate- and high-grade lesions.Conclusion:ADCs at 3.0 T showed an inverse relationship to Gleason grades in @entity2 . A high discriminatory performance was achieved in the differentiation of low-, intermediate-, and high-grade @entity1 .   RSNA, 2011.

title: Relationship between Apparent Diffusion Coefficients at 3.0-T MR Imaging and Gleason Grade in Peripheral Zone XXXX .

answer: @entity2


abstract: Myocardial fractional flow reserve (FFR) is a new index of the functional significance of intermediate coronary stenoses that is calculated from pressure measurements made during coronary arteriography. The aim of this study was to evaluate the correlation between non-hyperemic coronary pressure dicrotic notch and fractional flow reserve (FFR). A consecutive of 114 @entity0 (73 @entity0 and 41 @entity0 ) was enrolled in this study. Data were shown as means    SD. Statistical analyses were performed with SPSS software. The statistical significance of differences was determined by chi-square analysis with Yates correction. Significance was defined as P< 0.05. Positive dicrortic notch was observed in 97 @entity0 (85%). Significant association was detected between coronary pressure notch (dicrotic notch), and FFR as loss of the dicrotic notch was detected in 93.8% (15/16) of @entity0 with FFR less than 0.75 (P=0.001). Upon ROC curve, a cutoff FFR value of approximately 0.75 demonstrated sensivity and specifity of 93.8% and 98%, respectively for loss of the dicrotic notch. The positive predictive value for loss of the dicrotic notch was 88.2%. Our study demonstrated loss of non-hyperemic coronary pressure diacrotic notch correlates significantly with FFR and may predict an FFR < 0.75 with high accuracy. In @entity0 with functionally significant @entity1 , loss of non-hyperemic diacrotic notch appears to be a useful index of the functional severity of the stenoses and the need for coronary revascularization.

title: The non-hyperemic coronary pressure notch as an indicator of the physiologic significance of XXXX .

answer: @entity1


abstract: PURPOSE: To describe our initial experience with the novel 5   F SOFIA (Soft Torqueable catheter Optimized For Intracranial Access) intermediate and aspiration catheter for endovascular treatment of @entity0 with acute @entity2 . METHODS: A retrospective review was performed in three centers of prospectively collected data of all @entity1 @entity0 who underwent endovascular therapy using the SOFIA catheter. @entity0 were enrolled between November 2013 and December 2014. The primary endpoint of the study was accessibility of the @entity3 with the SOFIA catheter. As a secondary endpoint, the study assessed recanalization success ( @entity2 ( @entity2 ) >= 2b). Clinical presentation on admission and discharge was also documented. In addition, catheter- and procedure-related complications (particularly @entity4 complications) were recorded. RESULTS: The SOFIA catheter was used in 115 @entity1 . In 110 cases (96%) the catheter could be advanced to the occlusion site. After mechanical thrombectomy, successful recanalization ( @entity2 >= 2b) was documented in 86.9%. There were no complications related to positioning of the catheter. Distal @entity3 migration into a new vascular territory occurred in three @entity0 following thrombectomy with a stent retriever (2.6%). The mean NIH @entity1 Scale (NIHSS) score on admission was 16.8  6 and at discharge the mean NIHSS score was 8.2  7.7. Sixteen @entity0 died. CONCLUSIONS: The SOFIA catheter is a safe and efficient catheter for @entity1 therapy.

title: Initial experience with a new distal intermediate and aspiration catheter in the treatment of acute XXXX : clinical safety and efficacy.

answer: @entity2


abstract: OBJECTIVE: To investigate the effect of different natalizumab washout (WO) periods on recurrence of MRI and clinical disease activity in @entity0 switching from natalizumab to fingolimod. METHODS: In this multicenter, double-blind, placebo-controlled trial (TOFINGO), @entity0 with @entity4 ( @entity4 ) were randomized 1:1:1 to 8-, 12-, or 16-week WO followed by fingolimod treatment over 32 weeks from last natalizumab infusion (LNI). Brain MRI was performed at baseline and weeks 8, 12, 16, 20, and 24. RESULTS: Of 142 enrolled and randomized @entity0 , 112 (78.9%) completed the study (8 weeks, n = 41/50; 12 weeks, n = 31/42; 16 weeks, n = 40/50). Number (95% confidence interval [CI]) of active (new/newly enlarged T2) lesions from LNI through 8 weeks of fingolimod treatment (primary outcome) was similar in the 8-week (2.1 [1.7-2.6]) and 12-week WO groups (1.7 [1.3-2.2]) and higher in the 16-week WO group (8.2 [7.3-9.1]). During the WO period only, the number (95% CI) of active lesions increased with increasing WO duration (8 weeks, 0.4 [0.2-0.6]; 12 weeks, 2.1 [1.6-2.6]; 16 weeks, 3.6 [3.0-4.2]). Over the 24 weeks from LNI, @entity3 -enhancing @entity1 counts were lower in the 8-week WO group (14.1 [5.67-22.53]) than in the 12-week (21.3 [1.41-41.19]) or 16-week (18.5 [8.40-28.60]) WO groups. More @entity0 were relapse-free in the 8-week (88%) and 12-week (91%) WO groups than the 16-week WO group (84%). Sixty-eight percent of @entity0 experienced adverse events (mostly mild/moderate), with similar incidence across groups. No unusually severe relapses or @entity2 occurred. CONCLUSIONS: Initiating fingolimod therapy 8-12 weeks after natalizumab discontinuation is associated with a lower risk of MRI and clinical disease reactivation than initiation after 16-week WO. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for @entity0 with @entity4 switching from natalizumab to fingolimod, shorter natalizumab WO periods are associated with less MRI disease activity than are longer WO periods.

title: Switching from natalizumab to fingolimod: A randomized, placebo-controlled study in XXXX .

answer: @entity4


abstract: @entity3 ( @entity3 ) includes @entity1 and @entity2 . Although much is known about risk factors for @entity3 , there is failure in administration of appropriate prophylaxis to @entity0 who are at risk for @entity3 . A paper-based reminder system is considered to be among the most effective methods of improving @entity3 prophylaxis in hospitalized @entity0 . However, their success relies on choosing an evidence-based institutional guideline and implementation of its recommendations. This study was carried out to detect the extent of application of the institutional guideline (Caprini score risk assessment sheet). The study was carried out in the Jordan University Hospital; 354 @entity0 were enrolled in the study and distributed among the following wards: nonorthopedic surgical (n = 119), medical (n = 220), and surgical orthopedic wards (n = 15). The risk assessment sheet was present in only 47.2% of the @entity0 's' files, and the scores in the files were estimated correctly in only 52.1% of cases. Prophylaxis received by @entity0 matched the recommendation of the Caprini score in 67.1% of the @entity0 . The degree of concordance of the @entity3 prophylaxis with the Caprini score was 59.9%. This study showed that the institutional guideline was poorly implemented in the hospital.

title: Evaluation of XXXX prophylaxis after the introduction of an institutional guideline: Extent of application and implementation of its recommendations.

answer: @entity3


abstract: UNASSIGNED: Acute @entity10 in adults is one of the most common @entity3 seen in general practitioners' consultations. Viral aetiology is the most common. Among bacterial causes, the main agent is @entity9 or group A b-haemolytic @entity9 (GABHS), which causes 5%-30% of the episodes. In the diagnostic process, clinical assessment scales can help clinicians to better predict suspected bacterial aetiology by selecting @entity0 who should undergo a rapid antigen detection test. If these techniques are not performed, an overdiagnosis of @entity7 often occurs, resulting in unnecessary prescriptions of antibiotics, most of which are broad spectrum. Consequently, management algorithms that include the use of predictive clinical rules and rapid tests have been set up. The aim of the treatment is speeding up symptom resolution, reducing the contagious time span and preventing local suppurative and @entity4 . @entity1 and @entity2 are the antibiotics of choice for the treatment of @entity10 . The association of @entity2 and @entity6 is not indicated as the initial treatment of @entity5 . Neither are macrolides indicated as first-line therapy; they should be reserved for @entity0 allergic to @entity1 . The appropriate diagnosis of @entity8 and proper use of antibiotics based on the scientific evidence available are crucial. Using management algorithms can be helpful in identifying and screening the cases that do not require antibiotic therapy.

title: [Recommendations for management of acute XXXX in adults].

answer: @entity10


abstract: BACKGROUND: Modifying some lifestyle factors can be useful in @entity1 , at least as an adjuvant treatment. Combining different lifestyle interventions seems to be an adequate strategy to increase their antidepressant efficacy according with preliminary studies, but this issue has not been enough investigated. METHODS: The present study is a randomized, double-blinded, multicentre, two arm-parallel clinical trials, with a 12 month follow-up. The sample consisted of 273 Primary Care @entity0 . Four combined hygienic-dietary written recommendations were given to the @entity0 about diet, exercise, light exposure and sleep hygiene. RESULTS: Both active and control interventions were associated with improvement on BDI (Beck @entity1 Inventory) scores. However, there were not statistically significant differences (7.0 vs. 7.6; p=0.594). LIMITATIONS: We were unable to monitor whether @entity0 carry out recommendations. Intervention could be too difficult to accomplish for @entity1 @entity0 without enough support and supervision. CONCLUSIONS: Just giving written lifestyle recommendations are not enough for @entity1 @entity0 to benefit from them, so perhaps lifestyle change recommendations work or do not work on @entity1 depending on how they are presented to @entity0 and on monitoring systems of their implementation.

title: Lifestyle change recommendations in major XXXX : Do they work?

answer: @entity1


abstract: OBJECTIVES: To determine whether geriatric conditions and functional impairment are independent risk factors for @entity2 ( @entity2 ). DESIGN: Prospective cohort study. SETTING: Veterans Affairs Medical Center. @entity0 : Three hundred seventy-seven veterans aged 65 and older and taking five or more medications. MEASUREMENTS: Geriatric conditions and functional status were assessed using @entity0 interviews and structured assessments at study baseline. @entity2 were elicited during @entity0 interviews 3 and 12 months after study enrollment using validated methods. RESULTS: The strong majority (97%) of @entity0 were male, with a mean age of 74    5; 123 (33%) had one or more dependencies in instrumental activities of daily living (IADLs). Over the 1-year study period, 126 @entity0 (33%) developed 167 @entity2 . Upon multivariable analysis, risk of @entity2 was not associated with any of the geriatric conditions that there was sufficient power to evaluate, including IADL function, @entity1 , @entity4 , @entity3 , @entity5 , @entity6 , and a summative measure of geriatric burden comprising the above and history of falls or gait instability. In exploratory analyses, the strongest factor associated with @entity2 was the number of drugs added to a @entity0 's medication regimen during the 1-year study period (incidence rate ratio 1.11 per each added drug, 95% confidence interval=1.03-1.19). CONCLUSION: Common geriatric conditions and IADL function were not associated with @entity2 in a predominantly male, older veteran population. Although it is important to consider the unique circumstances of each @entity0 , excessive caution in prescribing to older adults with these geriatric conditions may not be warranted.

title: Geriatric conditions, medication use, and risk of XXXX in a predominantly male, older veteran population.

answer: @entity2


abstract: Protein aggregation is the hallmark of several @entity2 . These @entity5 (fibrillization) disorders are also known as @entity0 . The mechanism of @entity5 involves conformation switch of the native protein, oligomer formation leading to protofibrils and finally mature fibrils. Mature fibrils have long been considered as the cause of disease pathogenesis; however, recent evidences suggest oligomeric intermediates formed during fibrillization to be toxic. In this review, we have tried to address the ongoing debate for these toxic amyloid species. We did an extensive literature search and collated information from Pubmed (http://www.ncbi.nlm.nih. @entity6 ) and Google search using various permutations and combinations of the following keywords: @entity2 , @entity5 , fibrils, oligomers, @entity1 , @entity4 , @entity3 . We describe different instances showing the @entity1 of mature fibrils as well as oligomers in @entity4 and @entity3 . Distinct structural framework and morphology of amyloid oligomers suggests difference in toxic effect between oligomers and fibrils. We highlight the difference in structure and proposed @entity1 pathways for fibrils and oligomers. We also highlight the evidences indicating that intermediary oligomeric species can act as potential diagnostic biomarker. Since the formation of these toxic species follow a common structural switch among @entity0 , the @entity5 events can be targeted for developing broad-range therapeutics. The therapeutic trials based on the understanding of different protein conformers (monomers, oligomers, protofibrils and fibrils) in amyloid cascade are also described.

title: Toxic species in XXXX : Oligomers or mature fibrils.

answer: @entity0


abstract: A 22-year-old male student with no past medical illness, presented with acute onset @entity9 , @entity4 , and @entity5 over 10 hours. On examination, he had @entity3 , @entity1 , generalized @entity8 , and bilateral pupil sparing oculomotor, troclear, abducens, trigeminal, facial, glossopharyngeal, and @entity10 . Rest examination was unremarkable. @entity7 conduction study (NCS) showed decreased amplitude bilaterally and neurogenic pattern on electromyography. Limb NCS, repetitive nerve stimulation, @entity6 test, brain magnetic resonance imaging, cerebrospinal fluid, and biochemical tests were normal. Only positive tests were low thyroid-stimulating hormone (TSH) (<0.01), high free T3 (19.2 pmol/L), and high free T4 (39.2 pmol/L). Thyroid ultrasonography, anti-thyroid peroxidase, and anti-thyroglobulin antibody were normal. @entity0 was treated with anti-thyroid drugs, with which he completely recovered in 2 months. Though many cases with @entity2 have been reported, only few mention neuropathic cause of @entity5 or @entity11 cranialis. Getting done thyroid function tests may be helpful in @entity0 with @entity11 cranialis of uncertain etiology.

title: XXXX with generalized hyperreflexia as a presenting manifestation of thyrotoxicosis.

answer: @entity11


abstract: UNASSIGNED: The aim of the present study was to calculate the cost-effectiveness of on-demand and prophylactic treatments of severe @entity1 for Bulgarian @entity0 . The point of view is that of all @entity0 suffering from severe @entity1 . An epidemiological model was created, which includes data regarding the number of @entity0 divided into age groups up to 74  years. In the model, the transition age from prophylactic to on-demand treatment was gradually increased to up to 40  years. Costs of @entity3 factor, hospitalization, major surgery and indirect costs were considered; incremental cost-effectiveness ratio was calculated. The results showed that despite the increase in the costs for factor @entity2 with 20 million BGN, the saving obtained from other health services and indirect expenses reduce the overall expenses with 5.3 million BGN. If there is a gradual increase in the age when @entity0 are transferred from a prophylactic to an on-demand regimen, the costs for factor @entity2 would increase from 10.4 million to 19.7 million BGN, but due to a decrease in indirect costs as well as other health service costs, the total costs would decrease. The sensitivity analysis showed that the costs for clotting factor @entity2 are what influences the cost-effectiveness in both regimes. This indicates that decreases in the factor @entity2 cost will increase the overall efficiency in both regimes. In conclusion, the application of the prophylactic regime for @entity0 up to 40  years of age will provide better treatment, increase the quality of life and decrease the incremental costs.

title: Humanistic and economic aspects of XXXX treatment in Bulgaria. Comparison between two therapeutic approaches: prophylactic vs. on-demand treatment.

answer: @entity1


abstract: BACKGROUND: Purine @entity2 analogs (PNAs) constitute an important group of cytotoxic drugs for the treatment of neoplastic and @entity1 . In the present study, classification models have been developed for the prediction of the anti-HIV activity of purine @entity2 analogs. RESULTS: The topochemical version of superaugmented pendentic index-4 has been proposed and successfully utilized for the development of models. A total of 60 2D and 3D @entity0 ( @entity0 ) of diverse nature were selected for building the classification models using decision tree (DT), random forest (RF), support vector machine (SVM), and moving average analysis (MAA). The values of most of these descriptors for each of the analogs in the dataset were computed using the Dragon software (version 5.3). An in-house computer program was also employed to calculate additional @entity0 which were not included in the Dragon software. DT, RF, and SVM correctly classified the analogs into actives and inactives with an accuracy of 89  %, 83  %, and 78  %, respectively. MAA-based models predicted the anti-HIV activity of purine @entity2 analogs with a non-error rate up to 98  %. Therapeutic active spans of the suggested MAA-based models not only showed more potency but also exhibited enhanced safety as revealed by comparatively high values of selectivity index (SI). The statistical importance of the developed models was appraised via intercorrelation analysis, specificity, sensitivity, non-error rate, and Matthews correlation coefficient. CONCLUSIONS: High predictability of the proposed models clearly indicates an immense potential for developing lead molecules for potent but safe anti-HIV @entity3 analogs.

title: Diverse models for anti-HIV activity of purine XXXX analogs.

answer: @entity2


abstract: OBJECTIVE: The objective of this randomized controlled trial was to compare the treatment failure of suspected early onset @entity3 with either 3-day or 5-day course of empirical antibiotic therapy. METHODS: @entity0 with birth weight over 1500 g and/or gestational age over 34 weeks within 7 days postnatal age with clinical symptoms of @entity3 received empirical antibiotics ( @entity4 + @entity7 ) in two neonatal intensive care units. After 72 hours if the result of blood culture was negative and symptoms resolved they were randomly allocated to 3-day or 5-day groups. The main outcome was treatment failure which was defined as reappearance of symptoms of @entity3 within two weeks after discontinuation of antibiotics. @entity0 with @entity1 , @entity2 , @entity5 , those undergoing surgery or when serum @entity6 levels remained abnormal despite treatment, were not included. Randomization was accomplished with simple randomization procedure. FINDINGS: Sixty @entity0 were randomized in a 1:1 ratio to either group. Baseline characteristics were similar between two groups. The follow-up period was 2 weeks with no lost to follow-up. One @entity0 in 3-day group had treatment failure compared with no treatment failure in 5-day group (P=0.5). No serious harm was observed due to our empirical antibiotic regimen. CONCLUSION: The results of this study indicated no evidence that treatment failure differs between 3-day and 5-day course antibiotic therapy for suspected early onset @entity3 in late preterm and term newborns.

title: 3-Day versus 5-Day Course of Intravenous Antibiotics for Suspected Early Onset XXXX : A Randomized Controlled Trial.

answer: @entity3


abstract: BACKGROUND: Percutaneous endoscopic gastrostomy ( @entity3 ) allows long-term tube feeding. Safety of pull-type and introducer @entity3 placement in oncology @entity0 with head/neck or oesophageal @entity1 is unknown. METHODS: Retrospective analysis of 299 @entity0 undergoing @entity3 tube placement between January 2006 and December 2008 revealed 57 oncology @entity0 . All @entity0 with head/neck or oesophageal malignancy were treated with chemo- and radiotherapy. In case of high-grade stenosis introducer Freka   Pexact @entity3 tube was placed (n = 24) and in all other @entity0 (n = 33) conventional pull-type @entity3 tube. Short-term complications and mortality rates were compared. RESULTS: @entity0 ' characteristics and clinical status were comparable in both groups. Short-term complications were encountered in 11/24 (48%) introducer @entity3 @entity0 as compared to only 4/33 (12%) pull-type @entity3 @entity0 (P < 0.05). Accidental removal of the introducer @entity3 tube occurred in 4/24 (17%) with need for surgical intervention in 1 vs. 0/33 (0%, P < 0.05). @entity4 occurred in 3/24 (12%) leading to @entity2 and admission to intensive care unit (ICU) in 1 vs. 3/33 (9%, NS). Finally, 3/24 gastrointestinal perforations (12%) resulted from a difficult placement procedure vs. 1/33 (3%), leading to urgent surgical intervention and admission to ICU. Two introducer @entity3 @entity0 died at ICU, resulting in an overall mortality rate of 8% vs. 0% (P = 0.091). CONCLUSION: The introducer Freka   Pexact @entity3 procedure for long-term tube feeding may lead to significantly higher complication and mortality rates in @entity0 with head/neck or oesophageal @entity1 treated with chemo- and radiotherapy. It is suggested to use the conventional pull-type @entity3 tube placement in this group of @entity0 , if possible.

title: Safety of pull-type and introducer percutaneous endoscopic gastrostomy tubes in oncology XXXX : a retrospective analysis.

answer: @entity0


abstract: BACKGROUND: Violence is the cause of death for 1.5 million @entity0 in a year. OBJECTIVES: Our study aimed to estimate the incidence rate of self-reported interpersonal violence related @entity1 (VRPI) and its associated factors in Iran. @entity0 AND METHODS: The sample included @entity0 ranged from 15 to 64 years old who were residing in Iran. A total of 1525 clusters were selected from the whole country. Six families were selected from each cluster via a systematic random sampling method. Then, the residential units were identified and the interviewers contacted the inhabitants. In the next step, one of the family members was selected by using Kish grid method. The instrument was a researcher-made questionnaire and consisted of two sections; demographics and project related data. Face validity and content validity of our questionnaire were investigated based on expert opinions and the reliability was confirmed by a pilot study, as well. The inclusion criteria were considered for choosing the interviewers. An interviewer was assigned for each 42 @entity0 (7 clusters). An educational seminar was held for the administrative managers (54 @entity0 ) and interviewers (230 @entity0 ) for a week. The field work was distributed among all 46 Medical Sciences universities in Iran. In each university, administrative issues were related to an executive director. Mann-Whitney U test and odds ratio were used to analyze the data with 95% confidence interval. a value was considered less than 5%. RESULTS: The frequency of VRPI among 7886 @entity0 was 24 during the last three months. The incidence rate of interpersonal VRPI was estimated at 3.04 per 1000 population (95% CI: 2.66-3.42) during a three-month interval in Iran. The incidence was 4.72 per 1000 population (95% CI: 4.01-5.43) for males and 1.78 per 1000 population (95% CI: 1.39-2.17) for females during a three-month interval. The mean (SD) of age of the @entity0 with and without a history of VRPI were 26.5 (7.21) and 33.05 (12.05) years, respectively (P = 0.008). Considering the @entity0 ' gender, 66.7% were males (OR = 2.66, 95% CI: 1.14-6.23). Khuzestan Province had the most VRPIs (25% of all VRPIs). Streets and roads were the places with the highest frequency of injury (50%). The most frequent injured organ was the upper limb (54.17%). The most prevalent @entity1 was a superficial wound (50%). Finally, the most common place of treatment was home (45.83%). CONCLUSIONS: We determined the incidence rate of self-reported interpersonal VRPI for the first time in Iran based on a national survey. The injuries were more common among young @entity0 . We suggest consecutive national surveys with different data gathering methods and more sample sizes.

title: Incidence of self-reported interpersonal violence related XXXX in iran.

answer: @entity1


abstract: @entity3 ( @entity4 ) is an @entity2 . A particularly challenging aspect of management of @entity0 with @entity4 is optimizing treatment for recurrence, progression, and extracranial @entity1 . Here we describe a modern cohort of @entity0 with recurrent @entity4 to better understand treatment strategies that may improve outcome. @entity0 managed at UCSF for recurrent intracranial @entity4 were compiled into a single database based on a retrospective review of @entity0 records, including operative, radiologic, and clinic reports. Cox regression was performed to determine factors that independently predicted treatment outcomes. At UCSF, 14 @entity0 with available treatment and follow-up data were seen for management of @entity4 recurrence. Eight @entity0 underwent repeat surgical resection, of whom four received adjuvant external beam radiotherapy (EBRT), one received additional Gamma Knife radiosurgery (GKS), and one received brachytherapy. Radiosurgical intervention alone was utilized for recurrence in six @entity0 , with four receiving GKS and two receiving CyberKnife. Nine @entity0 suffered a second recurrence at a median time of 3.5 years following reintervention. Nine @entity0 died following reintervention, with a median survival of 7.9 years following intervention for recurrence. In univariate analysis, factors associated with increased time to second recurrence included non-posterior fossa location (log rank, p < 0.05) and surgical resection with adjuvant EBRT (log rank, p < 0.05). The addition of adjuvant EBRT to surgical resection similarly extended overall survival compared to surgical resection alone (log rank, p < 0.05). GKS was associated with earlier second recurrence compared to surgically based strategies (log rank, p < 0.05). We conclude that when combined with surgical resection, EBRT appears promising in the extension of second recurrence-free survival and overall survival. This multimodality approach also appears to outperform GKS in extending time to second recurrence. Accordingly, when safe and feasible, surgical resection of recurrent @entity4 with adjuvant EBRT should be the first steps in management.

title: Management of recurrent XXXX .

answer: @entity3


abstract: PURPOSE: Within a three-step mixed-methods study to investigate using acupuncture and moxibustion (acu/moxa) in the management of @entity1 treatment-related upper @entity3 , Step 2 obtained preliminary data about: 1) whether acu/moxa can improve quality of life, 2) the most troublesome symptoms, and 3) adverse effects. METHODS AND SAMPLE: An exploratory single-arm observational clinical study included breast (BC) and @entity2 ( @entity2 ) survivors with mild-to-moderate uncomplicated lymphoedema for >= 3 months, >= 3 months post active- @entity1 treatment, no active @entity1 , undergoing routine lymphoedema maintenance. @entity0 received seven individualised treatments (S1), and six optional additional treatments (S2). MYMOP, SF-36 and PANAS were administered at baseline, during each series, and at follow-up 4 and 12 weeks after end-of-treatment. The primary outcome was change in MYMOP scores at the end of each series. KEY RESULTS: Of 35 @entity0 recruited, 30 completed S1 and S2, 3 completed S1, 2 were lost to the study. Mean MYMOP profile change scores for BC @entity0 were 1.28 points improvement on a 7-point scale (sd  =  0.93, p  <  0.0001, n  =  25) for S1; and 1.41 for S2 (sd  =  0.94, p  <  0.0001, n  =  24). S1 @entity2 change scores were 2.29 points improvement (sd  =  0.62, p  <  0.0001, n  =  7); and 0.94 for S2 (sd  =  0.95, p  =  0.06, n  =  6). Changes in some SF-36 scores for BC @entity0 were significant to 4 weeks after treatment. No serious adverse effects were reported. CONCLUSION: This small study suggests acu/moxa is an acceptable adjunct to usual care for @entity1 survivors with lymphoedema. Further rigorous research is warranted to explore the effectiveness of acu/moxa in reducing the symptom burden.

title: Assessing the feasibility of using acupuncture and moxibustion to improve quality of life for @entity1 survivors with upper XXXX .

answer: @entity3


abstract: PURPOSE: Within a three-step mixed-methods study to investigate using acupuncture and moxibustion (acu/moxa) in the management of @entity1 treatment-related upper @entity3 , Step 2 obtained preliminary data about: 1) whether acu/moxa can improve quality of life, 2) the most troublesome symptoms, and 3) adverse effects. METHODS AND SAMPLE: An exploratory single-arm observational clinical study included breast (BC) and @entity2 ( @entity2 ) survivors with mild-to-moderate uncomplicated lymphoedema for >= 3 months, >= 3 months post active- @entity1 treatment, no active @entity1 , undergoing routine lymphoedema maintenance. @entity0 received seven individualised treatments (S1), and six optional additional treatments (S2). MYMOP, SF-36 and PANAS were administered at baseline, during each series, and at follow-up 4 and 12 weeks after end-of-treatment. The primary outcome was change in MYMOP scores at the end of each series. KEY RESULTS: Of 35 @entity0 recruited, 30 completed S1 and S2, 3 completed S1, 2 were lost to the study. Mean MYMOP profile change scores for BC @entity0 were 1.28 points improvement on a 7-point scale (sd  =  0.93, p  <  0.0001, n  =  25) for S1; and 1.41 for S2 (sd  =  0.94, p  <  0.0001, n  =  24). S1 @entity2 change scores were 2.29 points improvement (sd  =  0.62, p  <  0.0001, n  =  7); and 0.94 for S2 (sd  =  0.95, p  =  0.06, n  =  6). Changes in some SF-36 scores for BC @entity0 were significant to 4 weeks after treatment. No serious adverse effects were reported. CONCLUSION: This small study suggests acu/moxa is an acceptable adjunct to usual care for @entity1 survivors with lymphoedema. Further rigorous research is warranted to explore the effectiveness of acu/moxa in reducing the symptom burden.

title: Assessing the feasibility of using acupuncture and moxibustion to improve quality of life for XXXX survivors with upper @entity3 .

answer: @entity1


abstract: BACKGROUND: @entity6 @entity5 and @entity7 exert anti- @entity1 effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems. However, the complicated relationship between the anti- @entity1 effects of @entity6 and gene expression has yet to be defined under in vivo conditions. Therefore, we evaluated the relationship between the anti- @entity1 effects of Korean red @entity6 extract (KRGE) and hepatic gene expression profiles in @entity0 fed long-term on a high-fat diet (HFD) in this study. RESULTS: KRGE reduces the levels of @entity2 , low-density lipoprotein- @entity2 (LDL-C), serum @entity4 , and atherogenic indices. Levels of leptin, adiponectin and insulin, which regulate @entity3 and lipid metabolism, were impaired profoundly by HFD. However, KRGE treatment brought these levels back to normal. KRGE was found to down-regulate genes associated with lipid metabolism or @entity2 metabolism (Lipa, Cyp7a1, Il1rn, Acot2, Mogat1, Osbpl3, Asah3l, Insig1, Anxa2, Vldlr, Hmgcs1, Sytl4, Plscr4, Pla2g4e, Slc27a3, Enpp6), all of which were up-regulated by HFD. CONCLUSION: KRGE regulated the expression of genes associated with abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism, were shown to be modulated by KRGE. These results show that KRGE is effective in preventing @entity1 .

title: Lipid metabolic effect of Korean red XXXX extract in @entity0 fed on a high-fat diet.

answer: @entity6


abstract: BACKGROUND: @entity6 @entity5 and @entity7 exert anti- @entity1 effects via the modulation of physiological lipid metabolism in vivo or intracellular signalling in cell culture systems. However, the complicated relationship between the anti- @entity1 effects of @entity6 and gene expression has yet to be defined under in vivo conditions. Therefore, we evaluated the relationship between the anti- @entity1 effects of Korean red @entity6 extract (KRGE) and hepatic gene expression profiles in @entity0 fed long-term on a high-fat diet (HFD) in this study. RESULTS: KRGE reduces the levels of @entity2 , low-density lipoprotein- @entity2 (LDL-C), serum @entity4 , and atherogenic indices. Levels of leptin, adiponectin and insulin, which regulate @entity3 and lipid metabolism, were impaired profoundly by HFD. However, KRGE treatment brought these levels back to normal. KRGE was found to down-regulate genes associated with lipid metabolism or @entity2 metabolism (Lipa, Cyp7a1, Il1rn, Acot2, Mogat1, Osbpl3, Asah3l, Insig1, Anxa2, Vldlr, Hmgcs1, Sytl4, Plscr4, Pla2g4e, Slc27a3, Enpp6), all of which were up-regulated by HFD. CONCLUSION: KRGE regulated the expression of genes associated with abnormal physiology via HFD. Leptin, insulin, and adiponectin, which carry out critical functions in energy and lipid metabolism, were shown to be modulated by KRGE. These results show that KRGE is effective in preventing @entity1 .

title: Lipid metabolic effect of Korean red @entity6 extract in XXXX fed on a high-fat diet.

answer: @entity0


abstract: OBJECTIVE: Previous animal studies suggest a functional relationship between metabolism, @entity3 2 @entity1 , and the amplitude of daily rhythms in @entity5 ( @entity5 ). However, data interpretation is confounded by differences in genetic background and diet or limited sampling points. We have taken the novel approach of analyzing serial @entity0 @entity5 biopsies across a 24-h cycle in controlled laboratory conditions. RESEARCH DESIGN AND METHODS: Lean (n = 8), overweight/ @entity2 (n = 11), or overweight/ @entity2 @entity3 2 @entity1 (n = 8) volunteers followed a strict sleep-wake and dietary regimen for 1 week prior to the laboratory study. They were then maintained in controlled light-dark conditions in a semirecumbent posture and fed hourly during wake periods. Subcutaneous @entity5 biopsies were collected every 6 h over 24 h, and gene expression was measured by quantitative PCR. RESULTS: Lean individuals exhibited significant (P < 0.05) temporal changes of core clock ( @entity4 , @entity6 , @entity7 , @entity11 , @entity9 , and @entity10 ) and metabolic (REVERBa, @entity12 , and @entity8 ) genes. The @entity9 rhythm was in approximate antiphase with the other clock genes. It is noteworthy that there was no significant effect (P > 0.05) of increased body weight or @entity3 2 @entity1 on rhythmic gene expression. CONCLUSIONS: The robust nature of these rhythms and their relative phasing indicate that @entity5 now can be considered as a peripheral tissue suitable for the study of in vivo @entity0 rhythms. Comparison of data between subject groups clearly indicates that @entity2 and @entity3 2 @entity1 are not related to the amplitude of rhythmic @entity5 gene expression in @entity0 maintained under controlled conditions.

title: Rhythmic diurnal gene expression in @entity0 adipose tissue from individuals who are lean, overweight, and XXXX 2 @entity1 .

answer: @entity3


abstract: OBJECTIVE: Previous animal studies suggest a functional relationship between metabolism, @entity3 2 @entity1 , and the amplitude of daily rhythms in @entity5 ( @entity5 ). However, data interpretation is confounded by differences in genetic background and diet or limited sampling points. We have taken the novel approach of analyzing serial @entity0 @entity5 biopsies across a 24-h cycle in controlled laboratory conditions. RESEARCH DESIGN AND METHODS: Lean (n = 8), overweight/ @entity2 (n = 11), or overweight/ @entity2 @entity3 2 @entity1 (n = 8) volunteers followed a strict sleep-wake and dietary regimen for 1 week prior to the laboratory study. They were then maintained in controlled light-dark conditions in a semirecumbent posture and fed hourly during wake periods. Subcutaneous @entity5 biopsies were collected every 6 h over 24 h, and gene expression was measured by quantitative PCR. RESULTS: Lean individuals exhibited significant (P < 0.05) temporal changes of core clock ( @entity4 , @entity6 , @entity7 , @entity11 , @entity9 , and @entity10 ) and metabolic (REVERBa, @entity12 , and @entity8 ) genes. The @entity9 rhythm was in approximate antiphase with the other clock genes. It is noteworthy that there was no significant effect (P > 0.05) of increased body weight or @entity3 2 @entity1 on rhythmic gene expression. CONCLUSIONS: The robust nature of these rhythms and their relative phasing indicate that @entity5 now can be considered as a peripheral tissue suitable for the study of in vivo @entity0 rhythms. Comparison of data between subject groups clearly indicates that @entity2 and @entity3 2 @entity1 are not related to the amplitude of rhythmic @entity5 gene expression in @entity0 maintained under controlled conditions.

title: Rhythmic diurnal gene expression in @entity0 adipose tissue from individuals who are lean, overweight, and @entity3 2 XXXX .

answer: @entity1


abstract: OBJECTIVE: Previous animal studies suggest a functional relationship between metabolism, @entity3 2 @entity1 , and the amplitude of daily rhythms in @entity5 ( @entity5 ). However, data interpretation is confounded by differences in genetic background and diet or limited sampling points. We have taken the novel approach of analyzing serial @entity0 @entity5 biopsies across a 24-h cycle in controlled laboratory conditions. RESEARCH DESIGN AND METHODS: Lean (n = 8), overweight/ @entity2 (n = 11), or overweight/ @entity2 @entity3 2 @entity1 (n = 8) volunteers followed a strict sleep-wake and dietary regimen for 1 week prior to the laboratory study. They were then maintained in controlled light-dark conditions in a semirecumbent posture and fed hourly during wake periods. Subcutaneous @entity5 biopsies were collected every 6 h over 24 h, and gene expression was measured by quantitative PCR. RESULTS: Lean individuals exhibited significant (P < 0.05) temporal changes of core clock ( @entity4 , @entity6 , @entity7 , @entity11 , @entity9 , and @entity10 ) and metabolic (REVERBa, @entity12 , and @entity8 ) genes. The @entity9 rhythm was in approximate antiphase with the other clock genes. It is noteworthy that there was no significant effect (P > 0.05) of increased body weight or @entity3 2 @entity1 on rhythmic gene expression. CONCLUSIONS: The robust nature of these rhythms and their relative phasing indicate that @entity5 now can be considered as a peripheral tissue suitable for the study of in vivo @entity0 rhythms. Comparison of data between subject groups clearly indicates that @entity2 and @entity3 2 @entity1 are not related to the amplitude of rhythmic @entity5 gene expression in @entity0 maintained under controlled conditions.

title: Rhythmic diurnal gene expression in XXXX adipose tissue from individuals who are lean, overweight, and @entity3 2 @entity1 .

answer: @entity0


abstract: @entity1 ( @entity1 ) is a major cause of @entity0 in much of the world. Most CRCs arise from pre-malignant ( @entity10 ) lesions, such as @entity11 , and current endoscopic screening approaches with white light do not detect all @entity3 . Thus, new strategies to identify such lesions, including @entity3 , are needed. We aim to identify and validate novel peptides that specifically @entity6 in vivo. We used phage display to identify a novel peptide that binds to @entity5 in vivo in a genetically engineered @entity2 model of colo-rectal tumorigenesis, based on somatic @entity7 ( @entity7 ) gene inactivation. Binding was confirmed using confocal microscopy on biopsied @entity4 and excised @entity4 incubated with peptide ex vivo. Studies of @entity2 where a mutant @entity12 allele was somatically activated in the colon to generate @entity9 epithelium were also performed for comparison. Several rounds of in vivo T7 library biopanning isolated a peptide, QPIHPNNM. The fluorescent-labeled peptide bound to @entity3 on endoscopic analysis. Quantitative assessment revealed the fluorescent-labeled peptide (target/background: 2.17  0.61) binds    2-fold greater to the @entity8 when compared to the control peptide (target/background: 1.14  0.15), p<0.01. The peptide did not bind to the non- @entity10 ( @entity9 ) epithelium of the @entity12 @entity2 . This work is first to image fluorescence-labeled peptide binding in vivo that is specific towards @entity5 on wide-area surveillance. This finding highlights an innovative strategy for targeted detection to localize pre-malignant lesions that can be generalized to the epithelium of hollow organs.

title: In vivo fluorescence-based endoscopic detection of XXXX in the @entity2 using a novel peptide probe.

answer: @entity5


abstract: @entity1 ( @entity1 ) is a major cause of @entity0 in much of the world. Most CRCs arise from pre-malignant ( @entity10 ) lesions, such as @entity11 , and current endoscopic screening approaches with white light do not detect all @entity3 . Thus, new strategies to identify such lesions, including @entity3 , are needed. We aim to identify and validate novel peptides that specifically @entity6 in vivo. We used phage display to identify a novel peptide that binds to @entity5 in vivo in a genetically engineered @entity2 model of colo-rectal tumorigenesis, based on somatic @entity7 ( @entity7 ) gene inactivation. Binding was confirmed using confocal microscopy on biopsied @entity4 and excised @entity4 incubated with peptide ex vivo. Studies of @entity2 where a mutant @entity12 allele was somatically activated in the colon to generate @entity9 epithelium were also performed for comparison. Several rounds of in vivo T7 library biopanning isolated a peptide, QPIHPNNM. The fluorescent-labeled peptide bound to @entity3 on endoscopic analysis. Quantitative assessment revealed the fluorescent-labeled peptide (target/background: 2.17  0.61) binds    2-fold greater to the @entity8 when compared to the control peptide (target/background: 1.14  0.15), p<0.01. The peptide did not bind to the non- @entity10 ( @entity9 ) epithelium of the @entity12 @entity2 . This work is first to image fluorescence-labeled peptide binding in vivo that is specific towards @entity5 on wide-area surveillance. This finding highlights an innovative strategy for targeted detection to localize pre-malignant lesions that can be generalized to the epithelium of hollow organs.

title: In vivo fluorescence-based endoscopic detection of @entity5 in the XXXX using a novel peptide probe.

answer: @entity2