abstract: BACKGROUND: This study was performed to evaluate three-dimensional positional change of the condyle using three-dimensional computed tomography (3D-CT) following unilateral sagittal split ramus osteotomy (USSRO) in @entity0 with mandibular prognathism. METHODS: This study examined two @entity0 exhibiting skeletal @entity2 with @entity3 who underwent USSRO for a mandibular setback. 3D-CT was performed before surgery, immediately after surgery, and 6  months postoperatively. After creating 3D-CT images by using the In-vivo 5    program, the axial plane, coronal plane, and sagittal plane were configured. Three-dimensional positional changes from each plane to the condyle, @entity1 ( @entity1 ), @entity1 ( @entity1 ), @entity1 ( @entity1 ), frontal condylar head position (FHP), @entity1 ( @entity1 ), and sagittal condylar head position (SHP) of the two @entity0 were measured before surgery, immediately after surgery, and 6  months postoperatively. RESULTS: In the first @entity0 , medial rotation of the operated condyle in @entity1 and anterior rotation in @entity1 were observed. There were no significant changes after surgery in @entity1 , FHP, and SHP after surgery. In the second @entity0 , medial rotation of the operated condyle in @entity1 and lateral rotation of the operated condyle in @entity1 were observed. There were no significant changes in @entity1 , FHP, and SHP postoperatively. This indicates that in USSRO, postoperative movement of the condylar head is insignificant; however, medial rotation of the condylar head is possible. Although three-dimensional changes were observed, these were not clinically significant. CONCLUSIONS: The results of this study suggest that although three-dimensional changes in condylar head position are observed in @entity0 post SSRO, there are no significant changes that would clinically affect the @entity0 .

title: Condylar positioning changes following unilateral sagittal split ramus osteotomy in XXXX with mandibular prognathism.

answer: @entity0


abstract: UNASSIGNED: Modeling cellular metabolism is fundamental for many biotechnological applications, including drug discovery and rational cell factory design. Central @entity0 metabolism (CCM) is particularly important as it provides the energy and precursors for other biological processes. However, the complex regulation of CCM pathways has still not been fully unraveled and recent studies have shown that CCM is mostly regulated at post-transcriptional levels. In order to better understand the role of allosteric regulation in controlling the metabolic phenotype, we expand the reconstruction of CCM in @entity1 with @entity3 obtained from relevant databases. This model is used to integrate multi-omics datasets and analyze the coordinated changes in enzyme, metabolite, and flux levels between multiple experimental conditions. We observe cases where @entity3 have a major contribution to the metabolic flux changes. Inspired by these results, we develop a constraint-based method (arFBA) for simulation of metabolic flux distributions that accounts for @entity3 . This method can be used for systematic prediction of potential allosteric regulation under the given experimental conditions based on experimental data. We show that arFBA allows predicting coordinated flux changes that would not be predicted without considering allosteric regulation. The results reveal the importance of key regulatory metabolites, such as @entity2 , in controlling the metabolic flux. Accounting for @entity3 in metabolic reconstructions reveals a hidden topology in metabolic networks, improving our understanding of cellular metabolism and fostering the development of novel simulation methods that account for this type of regulation.

title: Modeling the Contribution of Allosteric Regulation for Flux Control in the Central @entity0 Metabolism of XXXX .

answer: @entity1


abstract: UNASSIGNED: Modeling cellular metabolism is fundamental for many biotechnological applications, including drug discovery and rational cell factory design. Central @entity0 metabolism (CCM) is particularly important as it provides the energy and precursors for other biological processes. However, the complex regulation of CCM pathways has still not been fully unraveled and recent studies have shown that CCM is mostly regulated at post-transcriptional levels. In order to better understand the role of allosteric regulation in controlling the metabolic phenotype, we expand the reconstruction of CCM in @entity1 with @entity3 obtained from relevant databases. This model is used to integrate multi-omics datasets and analyze the coordinated changes in enzyme, metabolite, and flux levels between multiple experimental conditions. We observe cases where @entity3 have a major contribution to the metabolic flux changes. Inspired by these results, we develop a constraint-based method (arFBA) for simulation of metabolic flux distributions that accounts for @entity3 . This method can be used for systematic prediction of potential allosteric regulation under the given experimental conditions based on experimental data. We show that arFBA allows predicting coordinated flux changes that would not be predicted without considering allosteric regulation. The results reveal the importance of key regulatory metabolites, such as @entity2 , in controlling the metabolic flux. Accounting for @entity3 in metabolic reconstructions reveals a hidden topology in metabolic networks, improving our understanding of cellular metabolism and fostering the development of novel simulation methods that account for this type of regulation.

title: Modeling the Contribution of Allosteric Regulation for Flux Control in the Central XXXX Metabolism of @entity1 .

answer: @entity0


abstract: UNASSIGNED: The present study investigated the projections of the gigantocellular reticular nucleus (Gi) and its neighbors-the dorsal paragigantocellular reticular nucleus (DPGi), the alpha/ventral part of the gigantocellular reticular nucleus (GiA/V), and the lateral paragigantocellular reticular nucleus (LPGi)-to the @entity0 spinal cord by injecting the anterograde tracer biotinylated dextran amine (BDA) into the Gi, DPGi, GiA/ @entity3 , and LPGi. The Gi projected to the entire spinal cord bilaterally with an ipsilateral predominance. Its fibers traveled in both the ventral and lateral funiculi with a greater presence in the ventral funiculus. As the fibers descended in the spinal cord, their density in the lateral funiculus increased. The terminals were present mainly in laminae 7-10 with a dorsolateral expansion caudally. In the lumbar and sacral cord, a considerable number of terminals were also present in laminae 5 and 6. Contralateral fibers shared a similar pattern to their ipsilateral counterparts and some fibers were seen to cross the midline. Fibers arising from the DPGi were similarly distributed in the spinal cord except that there was no dorsolateral expansion in the lumbar and sacral segments and there were fewer fiber terminals. Fibers arising from GiA/V predominantly traveled in the ventral and lateral funiculi ipsilaterally. Ipsilaterally, the density of fibers in the ventral funiculus decreased along the @entity2 , whereas the density of fibers in the lateral funiculus increased. They terminate mainly in the medial ventral horn and lamina 10 with a smaller number of fibers in the dorsal horn. Fibers arising from the LPGi traveled in both the ventral and lateral funiculi and the density of these fibers in the ventral and lateral funiculi decreased dramatically in the lumbar and sacral segments. Their terminals were present in the ventral horn with a large portion of them terminating in the motor neuron columns. The present study is the first demonstration of the termination pattern of fibers arising from the Gi, DPGi, GiA/ @entity3 , and LPGi in the @entity0 spinal cord. It provides an anatomical foundation for those who are conducting @entity1 and locomotion related research.

title: Terminations of reticulospinal fibers originating from the gigantocellular reticular formation in the XXXX spinal cord.

answer: @entity0


abstract: UNASSIGNED: In some conditions, female sexual behavior in ovariectomized @entity0 can be induced by continuous exposure of @entity1 (E2) alone or by a single injection of a high dose of the long-lasting, esterified @entity7 (EB). However, there are inconsistencies in the literature on the role of @entity2 during priming or in the facilitation on female sexual behavior in EB-primed @entity0 , as well as the cellular mechanisms involved. Either subcutaneous (sc) or intracerebral (icv) administration of some doses of free unesterified E2, induced @entity5 in EB-primed @entity0 . Either sc or icv injection of E2, immediately prior to testing, induced high levels of sexual receptivity when the female @entity0 were primed with an EB sc injection of 2  g EB. The roles of @entity4 receptor (PR) and @entity2 receptor on @entity5 induced by sc or icv administration of E2 were explored. @entity3 or @entity6 administrated sc or icv; each reduced @entity5 induced by E2. Similarly, antisense oligonucleotides directed at @entity8 or total PR (PR-A + @entity8 ) administrated icv immediately before EB injection inhibited @entity5 induced by daily injections of EB. These results suggest that @entity5 facilitated by free E2 is dependent on priming dose of EB. Furthermore both ERs and PRs are involved in this action of E2. (PsycINFO Database Record

title: Sexual Receptivity Facilitated by Unesterified @entity1 : Dependence on @entity2 and Progestin Receptors and Priming Dose of XXXX .

answer: @entity7


abstract: UNASSIGNED: In some conditions, female sexual behavior in ovariectomized @entity0 can be induced by continuous exposure of @entity1 (E2) alone or by a single injection of a high dose of the long-lasting, esterified @entity7 (EB). However, there are inconsistencies in the literature on the role of @entity2 during priming or in the facilitation on female sexual behavior in EB-primed @entity0 , as well as the cellular mechanisms involved. Either subcutaneous (sc) or intracerebral (icv) administration of some doses of free unesterified E2, induced @entity5 in EB-primed @entity0 . Either sc or icv injection of E2, immediately prior to testing, induced high levels of sexual receptivity when the female @entity0 were primed with an EB sc injection of 2  g EB. The roles of @entity4 receptor (PR) and @entity2 receptor on @entity5 induced by sc or icv administration of E2 were explored. @entity3 or @entity6 administrated sc or icv; each reduced @entity5 induced by E2. Similarly, antisense oligonucleotides directed at @entity8 or total PR (PR-A + @entity8 ) administrated icv immediately before EB injection inhibited @entity5 induced by daily injections of EB. These results suggest that @entity5 facilitated by free E2 is dependent on priming dose of EB. Furthermore both ERs and PRs are involved in this action of E2. (PsycINFO Database Record

title: Sexual Receptivity Facilitated by Unesterified XXXX : Dependence on @entity2 and Progestin Receptors and Priming Dose of @entity7 .

answer: @entity1


abstract: UNASSIGNED: In some conditions, female sexual behavior in ovariectomized @entity0 can be induced by continuous exposure of @entity1 (E2) alone or by a single injection of a high dose of the long-lasting, esterified @entity7 (EB). However, there are inconsistencies in the literature on the role of @entity2 during priming or in the facilitation on female sexual behavior in EB-primed @entity0 , as well as the cellular mechanisms involved. Either subcutaneous (sc) or intracerebral (icv) administration of some doses of free unesterified E2, induced @entity5 in EB-primed @entity0 . Either sc or icv injection of E2, immediately prior to testing, induced high levels of sexual receptivity when the female @entity0 were primed with an EB sc injection of 2  g EB. The roles of @entity4 receptor (PR) and @entity2 receptor on @entity5 induced by sc or icv administration of E2 were explored. @entity3 or @entity6 administrated sc or icv; each reduced @entity5 induced by E2. Similarly, antisense oligonucleotides directed at @entity8 or total PR (PR-A + @entity8 ) administrated icv immediately before EB injection inhibited @entity5 induced by daily injections of EB. These results suggest that @entity5 facilitated by free E2 is dependent on priming dose of EB. Furthermore both ERs and PRs are involved in this action of E2. (PsycINFO Database Record

title: Sexual Receptivity Facilitated by Unesterified @entity1 : Dependence on XXXX and Progestin Receptors and Priming Dose of @entity7 .

answer: @entity2


abstract: BACKGROUND: Complete revascularisation (CR) by means of percutaneous coronary intervention (PCI) has been associated with better long-term prognosis than incomplete revascularisation (IR) in several clinical trials. However, in the published studies, the completeness of @entity2 has been judged mainly on an anatomical basis, while including criteria directed at functionally driven IR might lead to different results. AIM: To examine the potential value of functionally driven IR in a large cohort of @entity0 with multivessel @entity3 (MVD) undergoing PCI. METHODS: The study population consisted of 908 @entity0 with MVD undergoing PCI without stenting between 1988 and 1997. Functionally driven IR was defined as dilation of all segments with >70% stenosis, with the exception of arteries supplying an area of previous transmural @entity4 ( @entity4 ) or a small amount of myocardium. Complete revascularisation was defined as successful PCI of all coronary artery lesions with significant narrowing not fulfilling the above criteria. @entity0 were followed for a mean 11 years (range 8-16 years). End-points included: death, @entity4 , re-PCI or coronary artery bypass grafting (CABG). RESULTS: Complete revascularisation was performed in 284 (31.3%) @entity0 . Follow-up was obtained from 873 (96.1%) @entity0 . There was no significant difference in the frequency of all-cause mortality, @entity1 or @entity4 between @entity0 who underwent CR and IR. @entity0 who underwent IR were more likely to require re-PCI and had a trend toward more frequent CABG. CONCLUSIONS: In comparison to CR, a strategy of functionally driven IR by means of PCI without stenting does not increase the rate of major cardiovascular outcomes, but is related to higher frequency of repeat procedures during a long-term follow-up.

title: Functionally driven complete vs incomplete revascularisation in multivessel XXXX --long-term results from a large cohort.

answer: @entity3


abstract: OBJECTIVE: Endoscopic transmural drainage and necrosectomy (ETDN) is a promising alternative to percutaneous drainage and surgical intervention in the treatment of walled-off pancreatic and peripancreatic necroses (WONs). We assessed the outcome and safety profile of ETDN in a single-center @entity0 cohort. MATERIALS AND METHODS: In November 2005, ETDN for WON was introduced in our tertiary referral center. During a 6-year period (Nov 2005-Nov 2011), we retrospectively collected data on all @entity0 who underwent ETDN. RESULTS: Eighty-one @entity0 were treated with ETDN (median age 54, 52 @entity0 ). @entity4 were the predominant etiology of @entity3 (41%), followed by alcohol (33%). Median time from debut of symptoms to first endoscopic treatment was 44 (9-246) days. Culture-proven infected @entity1 was found in 71% of the cases. Twenty-three @entity0 (28%) required admission in intensive care unit. The technical and clinical success rates were 99% and 89%, respectively. Procedure-related complications occurred in 10 (12%) @entity0 , of which 1 was procedure-related @entity2 . In-hospital mortality was 11%. CONCLUSION: ETDN in @entity0 with @entity3 and infected @entity1 performed in a single, high-volume center has an acceptable safety profile and is associated with a low mortality.

title: Endoscopic, transmural drainage and necrosectomy for walled-off pancreatic and peripancreatic XXXX is associated with low mortality - a single-center experience.

answer: @entity1


abstract: BACKGROUND: @entity8 ( @entity8 ) is rare. The risk of progression to @entity5 ( @entity5 ) is uncertain. OBJECTIVE: We sought to determine the risk of progression of pediatric @entity8 to @entity5 and to characterize its phenotype. METHODS: This was a retrospective review of 40 @entity0 with @entity8 . RESULTS: Six (15%) of 40 @entity0 presented with @entity8 as a manifestation of concurrent @entity5 . Of the remaining 34, 9 (26%) eventually met @entity5 criteria and 15 (44%) developed @entity4 without meeting @entity5 criteria. Only 10 (29%) maintained skin-limited disease. The average age at progression to @entity5 was 11 years, with greatest risk in the first year after @entity8 diagnosis. Most (89%) @entity0 with @entity5 met diagnostic criteria with @entity1 ( @entity2 , @entity7 , oral and nasal ulcers, photosensitivity), positive antibodies, and/or @entity6 without developing end-organ damage over 5 years of median follow-up. LIMITATIONS: The study was retrospective. CONCLUSIONS: In pediatric @entity0 , @entity8 carries a significant risk of progression to @entity5 but may predict a milder phenotype of @entity3 . All @entity0 require careful monitoring for @entity5 , particularly within the first year of diagnosis.

title: The natural history of pediatric-onset XXXX .

answer: @entity8


abstract: AIM: Heavy @entity1 is one of the common health problems in @entity0 . The first-line therapy of heavy @entity1 is the medical therapy, but this is not successful. Currently, global ablation procedures were introduced for treating of heavy @entity1 . The aim of this study was to the analysis of the @entity0 with @entity2 performed operations of Cavaterm in our university affiliated hospital, and explores its effectiveness and acceptability. METHODS: A retrospective study was conducted on 30 @entity0 with @entity2 who were unresponsive to hormone therapy or not candidates for hysterectomy underwent endometrial ablation using Cavaterm. Preoperative and postoperative PBAC Scoring System was used to assess @entity2 . Outcome measures were @entity3 rates, reduction of menstrual flow rates, heavy @entity1 , menstrual and @entity0 ' satisfaction rates at 3, 6 and 12 months postoperative. RESULTS: After a follow-up at 3, 6, and 12 months postoperative, 36.7%, 43.3%, and 36.7% of @entity0 had a @entity4 , respectively. @entity3 rates were 56.7%, 50.0%, and 56.7% in the Cavaterm at 3, 6, and 12 months. The rate of @entity0 's reported good or excellent satisfaction was 93.3% in 12 months. During the follow-up period, no @entity0 received a subsequent hysterectomy. CONCLUSION: The findings of this research indicated that outcome with the Cavaterm was as good for @entity0 with @entity2 . Therefore, it is necessary to emphasize on lower operative and post-operative procedural risk and a deleterious effect on @entity0 who were unresponsive to hormone therapy.

title: Thermal balloon endometrial ablation in the treatment of heavy XXXX .

answer: @entity1


abstract: BACKGROUND: Oxidative stress could play a role in the development of @entity4 . There is some evidence to suggest that @entity3 and E supplements can reduce the risk of the disorder. We hypothesized its beneficial role in a group of pregnant @entity0 with essential @entity1 . METHODS: In this randomized controlled trial, we enrolled 50 pregnant @entity0 with essential @entity1 . We assigned the @entity0 1000 mg @entity3 and 400 IU natural @entity2 (RRR a @entity5 ; n = 25), daily from the second trimester of pregnancy until delivery or no supplementation (n = 25). Our primary endpoint was development of superimposed @entity4 , and main secondary endpoints were aggravation of @entity1 , need for admission, need to increase antihypertensive drugs, and small size for gestational age (<fifth customized birthweight centile). RESULTS: We analyzed 50 @entity0 who completed the study. The incidence of superimposed @entity4 was similar in vitamin and control groups (8% [n = 2] vs 12% [n = 3], p = 1.000). @entity3 and E supplementation also did not prevent aggravation of @entity1 in group of @entity0 who took it (12% [n = 3] vs 32% [n = 8], p = 0.172). Small size for gestational age babies did not differ between groups (4% [n = 2] vs 6% [n = 3], p = 1.000). CONCLUSION: @entity3 and E supplementation does not prevent development of superimposed @entity4 in @entity0 with essential @entity1 . Our results did not show any significant benefit of vitamin supplementation. There was some trend in lessening of @entity1 complications of pregnancy. Our results failed to find any correlation between development of superimposed @entity4 and oxidative stress.

title: XXXX and E supplementation does not reduce the risk of superimposed PE in pregnancy.

answer: @entity3


abstract: OBJECTIVE: Despite the fact that the total energy intake of Japanese @entity0 has decreased, the percentage of @entity1 @entity0 has increased. This suggests that the timing of meals is related to @entity1 . The purpose of the study was to investigate the relationship between the timing of meals and @entity1 , based on analyses of physical measurements, serum biochemical markers, nutrient intake, and lifestyle factors in the context of Chrononutrition. @entity0 AND METHODS: We analyzed data derived from 766 residents of Toon City (286 males and 480 females) aged 30 to 79 years who underwent detailed medical examinations between 2011 and 2013. These medical examinations included. (1) physical measurements (waist circumference, blood pressure, etc.); (2) serum biochemical markers (total @entity2 , etc.); (3) a detailed questionnaire concerning lifestyle factors such as family structure and daily habits (22 issues), exercise and eating habits (28 issues), @entity3 intake and smoking habits; (4) a food frequency questionnaire based on food groups (FFQg); and (5) a questionnaire concerning the times at which meals and snacks are consumed. RESULTS: The values for body mass index (BMI) and waist circumference were higher for @entity0 who ate dinner less than three hours before bedtime (<3-h group) than those who ate more than three hours before bedtime (>3-h group). The Chi-square test showed that there was a significant difference in eating habits, e.g., eating snacks, eating snacks at night, having dinner after 8 p.m., and having dinner after 9 p.m., between the <3-h group and the >3-h group. Multiple linear regression analysis showed that skipping breakfast significantly influenced both waist circumference (b = 5.271) and BMI (b = 1.440) and that eating dinner <3-h before going to bed only influenced BMI (b = 0.581). CONCLUSION: Skipping breakfast had a greater influence on both waist circumference and BMI than eating dinner <3-h before going to bed.

title: Skipping Breakfast is Correlated with XXXX .

answer: @entity1


abstract: INTRODUCTION: Lumbar drainage for cerebrospinal fluid (CSF) diversion in @entity1 ( @entity1 ) has been reported to be beneficial in small series. There is no consensus regarding the optimal candidates for lumbar drainage, timing of drain placement, or amount and duration of CSF drainage. METHODS: We performed a comprehensive review of the English literature reporting series of @entity0 with @entity1 undergoing CSF diversion with lumbar drains. Favorable clinical outcome was defined as modified Rankin Scale of 0--2 or Glasgow Outcome Scale as 4--5. RESULTS: A total of 8 studies reporting on 841 @entity0 were included. Of these, 446 @entity0 were treated with lumbar drains. Two studies were prospective and five studies had comparison groups. Most @entity0 undergoing lumbar drainage were in good clinical grade on presentation (394/446, 88%) and the majority had substantial clot burden on head CT. Among the five studies with a comparison group, lumbar drainage was associated with lower rates of symptomatic @entity2 or delayed @entity3 (20% vs 45%, p<0.001) and higher rates of favorable outcome (79.4% vs. 60.4% p<0.001). The complication rate was 3.5%. CONCLUSION: Lumbar drainage in @entity1 appears to be safe and associated with reduced rates of symptomatic @entity2 and improved clinical outcomes in @entity0 in good clinical grade with thick clot burden, but the quality of most available studies is weak. The optimal duration and rate of CSF diversion remains uncertain.

title: Lumbar drainage and delayed XXXX in @entity1 :a systematic review.

answer: @entity3


abstract: INTRODUCTION: Lumbar drainage for cerebrospinal fluid (CSF) diversion in @entity1 ( @entity1 ) has been reported to be beneficial in small series. There is no consensus regarding the optimal candidates for lumbar drainage, timing of drain placement, or amount and duration of CSF drainage. METHODS: We performed a comprehensive review of the English literature reporting series of @entity0 with @entity1 undergoing CSF diversion with lumbar drains. Favorable clinical outcome was defined as modified Rankin Scale of 0--2 or Glasgow Outcome Scale as 4--5. RESULTS: A total of 8 studies reporting on 841 @entity0 were included. Of these, 446 @entity0 were treated with lumbar drains. Two studies were prospective and five studies had comparison groups. Most @entity0 undergoing lumbar drainage were in good clinical grade on presentation (394/446, 88%) and the majority had substantial clot burden on head CT. Among the five studies with a comparison group, lumbar drainage was associated with lower rates of symptomatic @entity2 or delayed @entity3 (20% vs 45%, p<0.001) and higher rates of favorable outcome (79.4% vs. 60.4% p<0.001). The complication rate was 3.5%. CONCLUSION: Lumbar drainage in @entity1 appears to be safe and associated with reduced rates of symptomatic @entity2 and improved clinical outcomes in @entity0 in good clinical grade with thick clot burden, but the quality of most available studies is weak. The optimal duration and rate of CSF diversion remains uncertain.

title: Lumbar drainage and delayed @entity3 in XXXX :a systematic review.

answer: @entity1


abstract: @entity7 fixed-dose regimens attained better kidney function and comparable efficacy to @entity3 ( @entity6 ) in kidney transplant @entity0 , albeit with increased risks of certain adverse events. This post-hoc analysis evaluated whether a @entity0 subgroup with an acceptable risk-benefit profile could be identified. @entity7 exposure was a statistically significant predictor of serious @entity4 rate. One-hundred and eighty six kidney transplant @entity0 were re-categorized to above-median (AME) or below-median (BME) exposure groups. The 6-month biopsy-proven acute rejection rates in AME, BME and @entity6 groups were 7.8%, 15.7% and 17.7%, respectively. Measured glomerular filtration rate was higher in AME and BME groups versus @entity6 (61.2 and 67.9 vs. 53.9   mL/min) at Month 12. Fewer @entity0 developed @entity1 and @entity2 (IF/TA) at Month 12 in AME (20.5%) and BME (27.8%) groups versus @entity6 (48.3%). @entity4 occurred more frequently in the AME group (53.0%) than in BME (28.4%) or @entity6 (25.5%) groups. @entity5 ( @entity5 ) only occurred in the AME group. In kidney transplant @entity0 , the BME group preserved the clinical advantage of comparable acute rejection rates, improved renal function and a lower incidence of IF/TA versus @entity6 , and with similar rates of serious @entity4 and no @entity5 .

title: Evaluation of the effect of XXXX exposure on outcomes in kidney transplant @entity0 .

answer: @entity7


abstract: @entity7 fixed-dose regimens attained better kidney function and comparable efficacy to @entity3 ( @entity6 ) in kidney transplant @entity0 , albeit with increased risks of certain adverse events. This post-hoc analysis evaluated whether a @entity0 subgroup with an acceptable risk-benefit profile could be identified. @entity7 exposure was a statistically significant predictor of serious @entity4 rate. One-hundred and eighty six kidney transplant @entity0 were re-categorized to above-median (AME) or below-median (BME) exposure groups. The 6-month biopsy-proven acute rejection rates in AME, BME and @entity6 groups were 7.8%, 15.7% and 17.7%, respectively. Measured glomerular filtration rate was higher in AME and BME groups versus @entity6 (61.2 and 67.9 vs. 53.9   mL/min) at Month 12. Fewer @entity0 developed @entity1 and @entity2 (IF/TA) at Month 12 in AME (20.5%) and BME (27.8%) groups versus @entity6 (48.3%). @entity4 occurred more frequently in the AME group (53.0%) than in BME (28.4%) or @entity6 (25.5%) groups. @entity5 ( @entity5 ) only occurred in the AME group. In kidney transplant @entity0 , the BME group preserved the clinical advantage of comparable acute rejection rates, improved renal function and a lower incidence of IF/TA versus @entity6 , and with similar rates of serious @entity4 and no @entity5 .

title: Evaluation of the effect of @entity7 exposure on outcomes in kidney transplant XXXX .

answer: @entity0


abstract: OBJECTIVE: The objective of this study was to determine the mechanism by which activation of peroxisome proliferator-activated receptor-y promotes apoptosis of acinar cells in @entity1 . METHODS: AR42j cells pretreated with the peroxisome proliferator-activated receptor-y agonist @entity7 were activated by @entity6 as an in vitro model of acute @entity1 . Inflammatory cytokines and amylase were detected by enzyme-linked immunosorbent assay. Cell viability was determined by @entity5 assay. Cell apoptosis was measured by flow cytometry and terminal deoxynucleotidyl transferase-mediated @entity3 nick end labeling staining. Activity of caspases was determined. @entity4 and @entity2 levels were assayed by Western blot. RESULTS: Cytokines, amylase, and cellular proliferation decreased in @entity7 -pretreated cells. @entity7 increased the activity of caspases 3, 8, and 9 in @entity6 -activated AR42j cells as well as in the pancreas of @entity0 3 hours after induction of severe acute @entity1 . Acinar cell apoptosis was induced by reducing the mitochondrial membrane potential in the @entity7 group. @entity7 increased expression of proapoptotic @entity4 proteins and decreased antiapoptotic @entity2 in @entity6 -induced AR42j cells and decreased @entity2 levels in pancreatic tissue of severe acute @entity1 @entity0 1 and 3 hours after induction. CONCLUSION: @entity7 may promote apoptosis of acinar cells through both intrinsic and extrinsic apoptotic pathways in acute @entity1 .

title: Apoptotic Mechanisms of Peroxisome Proliferator-Activated Receptor-y Activation in Acinar Cells During Acute XXXX .

answer: @entity1


abstract: In a group of 1319 @entity0 with @entity3 treated in an intensive care unit from 1969-1977 30% died within the years 1969-1971 during the stay in the clinic. The hospital death-rate decreased significantly to 22% between the years 1975-1977, while the average age of the @entity0 was increasing, inspite of an increase in haemodynamically complicated @entity6 . The number of @entity0 in the age group of 50-69 years has decreased from 56% to 41%. The number of @entity0 aged 70 years and older increased, while lethality decreased from 53% to 32%. Lethality in @entity0 with total AV-block decreased, and was unchanged in @entity0 with @entity4 . The incidence of @entity8 increased, lethality in these @entity0 decreased. The high lethality of @entity0 with @entity7 remained unchangedly high. In @entity0 with all other forms of severe @entity5 lethality decreased, even in @entity0 aged 80 years and more. @entity1 occurred later during 1975-1977 compared to former periods. The interval between the beginning of symptoms and admission to the intensive care unit decreased, but has no more any prognostic significance. Improved survival is referred to effective treatment of life threatening @entity2 and of severe @entity5 .

title: [Advances in the therapy of XXXX . Prognosis and clinical course of acute @entity3 with intensive therapy].

answer: @entity3


abstract: In a group of 1319 @entity0 with @entity3 treated in an intensive care unit from 1969-1977 30% died within the years 1969-1971 during the stay in the clinic. The hospital death-rate decreased significantly to 22% between the years 1975-1977, while the average age of the @entity0 was increasing, inspite of an increase in haemodynamically complicated @entity6 . The number of @entity0 in the age group of 50-69 years has decreased from 56% to 41%. The number of @entity0 aged 70 years and older increased, while lethality decreased from 53% to 32%. Lethality in @entity0 with total AV-block decreased, and was unchanged in @entity0 with @entity4 . The incidence of @entity8 increased, lethality in these @entity0 decreased. The high lethality of @entity0 with @entity7 remained unchangedly high. In @entity0 with all other forms of severe @entity5 lethality decreased, even in @entity0 aged 80 years and more. @entity1 occurred later during 1975-1977 compared to former periods. The interval between the beginning of symptoms and admission to the intensive care unit decreased, but has no more any prognostic significance. Improved survival is referred to effective treatment of life threatening @entity2 and of severe @entity5 .

title: [Advances in the therapy of @entity3 . Prognosis and clinical course of acute XXXX with intensive therapy].

answer: @entity3


abstract: OBJECTIVES: @entity2 ( @entity2 ) is an aggressive disease in the head and neck region. Therefore, simple and useful prognostic predictors of @entity2 are needed for clinical practice. This study investigates the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) in @entity0 with @entity2 who received radical resections. METHODS: Retrospective review was conducted on medical records at a tertiary referral hospital involving 146 consecutive @entity0 who underwent radical resection for @entity2 between January 2000 and December 2010. The prognostic significance of NLR and other clinicopathologic factors was analyzed. The relationships between the NLR value and clinicopathologic factors were also evaluated. RESULTS: The study cohort consisted of 146 @entity0 with @entity2 , with a mean age of 57.5 years (range, 34-89 years). The median number of NLR was 2.28 (range, 0.71-8.75). On the basis of this median value, the cutoff value of NLR was set as 2.3. The @entity0 were divided into 2 groups: a low (<2.3) NLR group and a high (>= 2.3) NLR group. @entity0 with NLR of 2.3 or more had significantly higher incidence of wound complications (P = 0.026). The 3-year overall survival rate was 69.9% in @entity0 in the low NLR group and 27.4% in those in the high NLR group (P <0.001; hazard ratio;2.99; 95% confidence interval, 1.91-4.67). CONCLUSIONS: Results showed that high preoperative NLR is associated with @entity1 and poor survival in @entity0 with @entity2 .

title: Preoperative Neutrophil-to-Lymphocyte Ratio as Prognostic Predictor for XXXX after Radical Resections.

answer: @entity2


abstract: We describe a 54-year-old @entity0 who presented with right @entity4 . @entity5 had been prescribed to treat @entity3 , and the symptoms resolved. Subsequently, the @entity0 consulted a local physician because of right @entity4 . Giant folds were found in the greater curvature of the gastric body, and he was referred to the Department of Gastroenterology, Kitasato University East Hospital. Upper gastrointestinal endoscopy revealed markedly enlarged folds in the greater curvature of the stomach, with redness and @entity1 mucosa in the lesser curvature. Biopsy showed marked @entity2 (mainly eosinophils), but no atypical cells. Blood tests showed marked @entity6 and elevated immunoglobulin E levels in the serum. The results of various allergic examinations were negative, but the clinical course suggested drug-induced @entity7 , and treatment was started. @entity5 was withdrawn without adequate resolution of symptoms. Because the leukocyte and eosinophil counts continued to increase, the @entity0 was given suplatast, an anti-allergic agent. The symptoms and hematological values improved promptly. The @entity0 recovered uneventfully, with no recurrence.

title: XXXX associated with giant folds.

answer: @entity7


abstract: BACKGROUND: Personality determinants are an important predicator of @entity0 in drivers. The main objective of the study was to determine the relationship between @entity3 ( @entity2 , extraversion, level of @entity1 ) and distinguishable risky behaviors of drivers of medical transport vehicles. MATERIAL AND METHODS: The study covered 106 male drivers from the Wielkopolskie Voivodeship, working in health care, having a license to drive emergency vehicles. To achieve the research objectives a questionnaire was developed and applied. It concerned risky @entity0 among drivers of medical transport. The personality suitability was determined using the questionnaire methods on self-assessment: Polish versions of Eysenck Personality Questionnaire - Revised (EPQ-R) and the State-Trait @entity1 Inventory (STAI) questionnaire. RESULTS: It was shown that drivers with introverted characteristics declare driving vehicles of reduced technical efficiency more often than extroverts. The level of the @entity1 as a trait A-characteristic affects the display of distracting behaviors, making decisions about driving a vehicle that is inefficient, driving in a bad psychophysical condition, as well as maintaining too small distance from the preceding vehicle. The higher the intensity of @entity1 characteristics, the higher the intensity of given behaviors. CONCLUSIONS: Based on the study results, it can be assumed that there is a relationship between determinants of personality and the display of risky behaviors of drivers of medical transport vehicles. Thus it can be concluded that the level of extraversion and @entity1 as a trait are the differentiating characteristics of respondents.

title: [Determinants of personality and risky XXXX at work in drivers of medical transport vehicles in the Wielkopolska (Greater Poland) voivodeship].

answer: @entity0


abstract: It is well known that biological tissues adapt their properties because of different mechanical and chemical stimuli. The goal of this work is to study the collagen turnover in the arterial tissue of @entity1 @entity0 through a coupled computational mechano-chemical model. Although it has been widely studied experimentally, computational models dealing with the mechano-chemical approach are not. The present approach can be extended easily to study other aspects of bone remodeling or collagen degradation in @entity2 . The model can be divided into three different stages. First, we study the smooth muscle cell synthesis of different biological substances due to over-stretching during @entity1 . Next, we study the mass-transport of these substances along the arterial wall. The last step is to compute the turnover of collagen based on the amount of these substances in the arterial wall which interact with each other to modify the turnover rate of collagen. We simulate this process in a finite element model of a real @entity0 carotid artery. The final results show the well-known stiffening of the arterial wall due to the increase in the collagen content.

title: Computational model of collagen turnover in carotid arteries during XXXX .

answer: @entity1


abstract: BACKGROUND: American @entity1 (ACL) is a re-emerging disease in the state of S  o Paulo, Brazil. It is important to understand both the vector and disease distribution to help design control strategies. As an initial step in applying geographic information systems (GIS) and remote sensing (RS) tools to map disease-risk, the objectives of the present work were to: (i) produce a single database of species distributions of the sand @entity0 vectors in the state of S  o Paulo, (ii) create combined distributional maps of both the incidence of ACL and its sand @entity0 vectors, and (iii) thereby provide individual municipalities with a source of reference material for work carried out in their area. RESULTS: A database containing 910 individual records of sand @entity0 occurrence in the state of S  o Paulo, from 37 different sources, was compiled. These records date from between 1943 to 2009, and describe the presence of at least one of the six incriminated or suspected sand @entity0 vector species in 183/645 (28.4%) municipalities. For the remaining 462 (71.6%) municipalities, we were unable to locate records of any of the six incriminated or suspected sand @entity0 vector species (Nyssomyia intermedia, N. neivai, N. whitmani, Pintomyia fischeri, P. pessoai and Migonemyia migonei). The distribution of each of the six incriminated or suspected vector species of ACL in the state of S  o Paulo were individually mapped and overlaid on the incidence of ACL for the period 1993 to 1995 and 1998 to 2007. Overall, the maps reveal that the six sand @entity0 vector species analyzed have unique and heterogeneous, although often overlapping, distributions. Several sand @entity0 species - Nyssomyia intermedia and N. neivai - are highly localized, while the other sand @entity0 species - N. whitmani, M. migonei, @entity2 and P. pessoai - are much more broadly distributed. ACL has been reported in 160/183 (87.4%) of the municipalities with records for at least one of the six incriminated or suspected sand @entity0 vector species, while there are no records of any of these sand @entity0 species in 318/478 (66.5%) municipalities with ACL. CONCLUSIONS: The maps produced in this work provide basic data on the distribution of the six incriminated or suspected sand @entity0 vectors of ACL in the state of S  o Paulo, and highlight the complex and geographically heterogeneous pattern of ACL transmission in the region. Further studies are required to clarify the role of each of the six suspected sand @entity0 vector species in different regions of the state of S  o Paulo, especially in the majority of municipalities where ACL is present but sand @entity0 vectors have not yet been identified.

title: Geographical distribution of American XXXX and its phlebotomine vectors (Diptera: Psychodidae) in the state of S  o Paulo, Brazil.

answer: @entity1


abstract: BACKGROUND: The aim of this study was to develop and validate an automated method for extracting forward @entity0 volume ( @entity3 ) using indicator dilution theory directly from dynamic positron emission tomography (PET) studies for two different tracers and scanners. METHODS: 35 subjects underwent a dynamic @entity2 PET scan on a Siemens Biograph TruePoint-64 PET/CT (scanner I). In addition, 10 subjects underwent both dynamic @entity1 -water PET and @entity2 PET scans on a GE Discovery-ST PET/CT (scanner II). The left ventricular (LV)-aortic time-activity curve (TAC) was extracted automatically from PET data using cluster analysis. The first-pass peak was isolated by automatic extrapolation of the downslope of the TAC. @entity3 was calculated as the injected dose divided by the product of heart rate and the area under the curve of the first-pass peak. Gold standard @entity3 was measured using phase-contrast cardiovascular magnetic resonance (CMR). RESULTS: FSVPET correlated highly with FSVCMR (r   =   0.87, slope   =   0.90 for scanner I, r   =   0.87, slope   =   1.65, and r   =   0.85, slope   =   1.69 for scanner II for @entity1 -water and @entity2 , respectively) although a systematic bias was observed for both scanners (p   <   0.001 for all). @entity3 based on @entity2 and @entity1 -water correlated highly (r   =   0.99, slope   =   1.03) with no significant difference between @entity3 estimates (p   =   0.14). CONCLUSIONS: @entity3 can be obtained automatically using dynamic PET/CT and cluster analysis. Results are almost identical for @entity2 and @entity1 -water. A scanner-dependent bias was observed, and a scanner calibration factor is required for multi-scanner studies. Generalization of the method to other tracers and scanners requires further validation.

title: Automatic extraction of forward XXXX volume using dynamic PET/CT: a dual-tracer and dual-scanner validation in patients with heart valve disease.

answer: @entity0


abstract: OBJECTIVE: There are limited data concerning the evolution of radiation-induced @entity7 in adult-onset @entity4 (AO-BT) survivors; in part the consequence of the limited survival of many of these individuals. We aim to characterise the pituitary-related outcomes following cranial radiotherapy (cXRT) for adult-onset primary @entity4 . DESIGN: We retrospectively analyzed longitudinal data of @entity0 with AO-BT who received cXRT within a tertiary @entity1 referral center. @entity0 : 107 adults (age 40.0  13.1 years) followed for a median duration of eight years following cXRT. MEASUREMENTS: Prevalence of radiotherapy-induced @entity7 . RESULTS: 94.4% received fractionated photon radiotherapy (median dose 54Gy), while the remaining @entity0 received proton beam or stereotactic radiotherapy. 88.8% of @entity0 developed @entity7 during follow-up. The frequency of GH, gonadotropin, ACTH and @entity3 was 86.9% (severe GHD 64.5%, partial GHD 22.4%), 34.6%, 23.4% and 11.2% respectively. @entity9 was clinically significant, necessitating glucocorticoid replacement, in only 10.3% of cases. @entity5 developed in 15% of @entity0 , which was persistent in only 50% of cases. @entity8 were present in 47.7% of @entity0 ; encountered more frequently in @entity0 with @entity1 in proximity to the sella. Longitudinal data analysis revealed @entity2 throughout the follow-up period, with incidence of all @entity8 almost doubling between years 2 and 7 of follow-up. CONCLUSIONS: @entity6 in AO-BT survivors following cXRT is a common, evolving, time-dependent phenomenon. It is important deficits are identified early and replacement therapies introduced to optimize quality of life in these individuals, where prognosis is often guarded. This article is protected by copyright. All rights reserved.

title: @entity6 following cranial radiotherapy for adult-onset XXXX .

answer: @entity4


abstract: OBJECTIVE: There are limited data concerning the evolution of radiation-induced @entity7 in adult-onset @entity4 (AO-BT) survivors; in part the consequence of the limited survival of many of these individuals. We aim to characterise the pituitary-related outcomes following cranial radiotherapy (cXRT) for adult-onset primary @entity4 . DESIGN: We retrospectively analyzed longitudinal data of @entity0 with AO-BT who received cXRT within a tertiary @entity1 referral center. @entity0 : 107 adults (age 40.0  13.1 years) followed for a median duration of eight years following cXRT. MEASUREMENTS: Prevalence of radiotherapy-induced @entity7 . RESULTS: 94.4% received fractionated photon radiotherapy (median dose 54Gy), while the remaining @entity0 received proton beam or stereotactic radiotherapy. 88.8% of @entity0 developed @entity7 during follow-up. The frequency of GH, gonadotropin, ACTH and @entity3 was 86.9% (severe GHD 64.5%, partial GHD 22.4%), 34.6%, 23.4% and 11.2% respectively. @entity9 was clinically significant, necessitating glucocorticoid replacement, in only 10.3% of cases. @entity5 developed in 15% of @entity0 , which was persistent in only 50% of cases. @entity8 were present in 47.7% of @entity0 ; encountered more frequently in @entity0 with @entity1 in proximity to the sella. Longitudinal data analysis revealed @entity2 throughout the follow-up period, with incidence of all @entity8 almost doubling between years 2 and 7 of follow-up. CONCLUSIONS: @entity6 in AO-BT survivors following cXRT is a common, evolving, time-dependent phenomenon. It is important deficits are identified early and replacement therapies introduced to optimize quality of life in these individuals, where prognosis is often guarded. This article is protected by copyright. All rights reserved.

title: XXXX following cranial radiotherapy for adult-onset @entity4 .

answer: @entity6


abstract: Importance: @entity4 are associated with @entity1 within the aortic wall, and previous studies have suggested that @entity1 may be a consequence of a dysregulated and persistent autoimmune response. Persistent aortic remodeling after @entity3 repair could place the @entity0 at risk for endoleak or sac rupture. Objective: To determine whether @entity0 with systemic @entity1 and large @entity3 have persistent aortic remodeling after @entity3 repair (EVAR). Design, Setting, and @entity0 : The records of all @entity0 who underwent EVAR between July 2002 and June 2011 at the Veterans Affairs Connecticut Healthcare System were included in this retrospective review. @entity0 were considered to have a systemic @entity1 when confirmed by a referring specialist. Post-EVAR surveillance was performed by yearly imaging. Intervention: @entity3 repair. Main Outcomes and Measures: Significant endoleak, defined as endoleak and sac diameter increase of 0.5 cm or greater. Results: A total of 51 of 79 @entity0 (65%) had a systemic @entity1 . These @entity0 had similar comorbid conditions compared with @entity0 without @entity1 but significantly greater numbers of major @entity2 after EVAR (23.5% vs 3.6%; P   =   .02) and @entity2 after EVAR (27.5% vs 7.1%; P   =   .03). @entity0 with a history of systemic @entity1 developed more @entity5 (45.1% vs 17.9%; P   =   .02) and late sac expansion (51.0% vs 21.4%; P   =   .01) and required more interventions (21.6% vs 3.6%; P   =   .03) during long-term follow-up. Systemic @entity1 was significantly associated with significant endoleak (odds ratio, 5.18; 95% CI, 1.56-17.16; P   =   .007). Conclusions and Relevance: @entity0 with systemic @entity1 are at high risk for @entity2 , @entity5 , sac expansion, and additional interventions after EVAR. Additional strategies for improving the efficacy of EVAR in these @entity0 may be warranted.

title: @entity1 and Its Association With @entity5 and Late Interventions After XXXX Repair.

answer: @entity3


abstract: Importance: @entity4 are associated with @entity1 within the aortic wall, and previous studies have suggested that @entity1 may be a consequence of a dysregulated and persistent autoimmune response. Persistent aortic remodeling after @entity3 repair could place the @entity0 at risk for endoleak or sac rupture. Objective: To determine whether @entity0 with systemic @entity1 and large @entity3 have persistent aortic remodeling after @entity3 repair (EVAR). Design, Setting, and @entity0 : The records of all @entity0 who underwent EVAR between July 2002 and June 2011 at the Veterans Affairs Connecticut Healthcare System were included in this retrospective review. @entity0 were considered to have a systemic @entity1 when confirmed by a referring specialist. Post-EVAR surveillance was performed by yearly imaging. Intervention: @entity3 repair. Main Outcomes and Measures: Significant endoleak, defined as endoleak and sac diameter increase of 0.5 cm or greater. Results: A total of 51 of 79 @entity0 (65%) had a systemic @entity1 . These @entity0 had similar comorbid conditions compared with @entity0 without @entity1 but significantly greater numbers of major @entity2 after EVAR (23.5% vs 3.6%; P   =   .02) and @entity2 after EVAR (27.5% vs 7.1%; P   =   .03). @entity0 with a history of systemic @entity1 developed more @entity5 (45.1% vs 17.9%; P   =   .02) and late sac expansion (51.0% vs 21.4%; P   =   .01) and required more interventions (21.6% vs 3.6%; P   =   .03) during long-term follow-up. Systemic @entity1 was significantly associated with significant endoleak (odds ratio, 5.18; 95% CI, 1.56-17.16; P   =   .007). Conclusions and Relevance: @entity0 with systemic @entity1 are at high risk for @entity2 , @entity5 , sac expansion, and additional interventions after EVAR. Additional strategies for improving the efficacy of EVAR in these @entity0 may be warranted.

title: @entity1 and Its Association With XXXX and Late Interventions After @entity3 Repair.

answer: @entity5


abstract: Importance: @entity4 are associated with @entity1 within the aortic wall, and previous studies have suggested that @entity1 may be a consequence of a dysregulated and persistent autoimmune response. Persistent aortic remodeling after @entity3 repair could place the @entity0 at risk for endoleak or sac rupture. Objective: To determine whether @entity0 with systemic @entity1 and large @entity3 have persistent aortic remodeling after @entity3 repair (EVAR). Design, Setting, and @entity0 : The records of all @entity0 who underwent EVAR between July 2002 and June 2011 at the Veterans Affairs Connecticut Healthcare System were included in this retrospective review. @entity0 were considered to have a systemic @entity1 when confirmed by a referring specialist. Post-EVAR surveillance was performed by yearly imaging. Intervention: @entity3 repair. Main Outcomes and Measures: Significant endoleak, defined as endoleak and sac diameter increase of 0.5 cm or greater. Results: A total of 51 of 79 @entity0 (65%) had a systemic @entity1 . These @entity0 had similar comorbid conditions compared with @entity0 without @entity1 but significantly greater numbers of major @entity2 after EVAR (23.5% vs 3.6%; P   =   .02) and @entity2 after EVAR (27.5% vs 7.1%; P   =   .03). @entity0 with a history of systemic @entity1 developed more @entity5 (45.1% vs 17.9%; P   =   .02) and late sac expansion (51.0% vs 21.4%; P   =   .01) and required more interventions (21.6% vs 3.6%; P   =   .03) during long-term follow-up. Systemic @entity1 was significantly associated with significant endoleak (odds ratio, 5.18; 95% CI, 1.56-17.16; P   =   .007). Conclusions and Relevance: @entity0 with systemic @entity1 are at high risk for @entity2 , @entity5 , sac expansion, and additional interventions after EVAR. Additional strategies for improving the efficacy of EVAR in these @entity0 may be warranted.

title: XXXX and Its Association With @entity5 and Late Interventions After @entity3 Repair.

answer: @entity1


abstract: PURPOSE: To evaluate the @entity1 -inducing ability of a few leukemic cells xenotransplanted inside an artificial ovary. METHODS: Ten and 100 @entity0 leukemic cells were embedded in a fibrin matrix along with 50,000 @entity0 ovarian stromal cells, and grafted to the peritoneal bursa of 5 and 5 @entity5 @entity2 respectively. Four @entity2 grafted with 3x10(6) leukemic cells in fibrin served as positive controls. At 20 weeks post-transplantation, the grafts, liver, spleen, blood and bone marrow were analyzed for the presence of @entity6 by anti- @entity7 IHC, flow cytometry (FC) and PCR. RESULTS: All @entity2 grafted with 3x10(6) cells developed peritoneal masses 4 weeks after xenotransplantation, and @entity3 was confirmed by IHC, PCR and FC. Among @entity2 grafted with 10 or 100 leukemic cells, none showed any sign of @entity6 after 20 weeks, and IHC, FC and PCR on the different recovered tissues all proved negative. CONCLUSION: This study investigates the @entity1 -inducing potential of a few leukemic cells grafted inside an artificial ovary. Transplantation of 100 leukemic cells appears to be insufficient to induce @entity6 after 20 weeks. These results in an @entity4 xenografting model are quite reassuring. However, for clinical application, follicle suspensions must be purged of leukemic cells before grafting, as even the slightest risk should be avoided.

title: Is transplantation of a few leukemic cells inside an artificial ovary able to induce XXXX in an experimental model?

answer: @entity6


abstract: BACKGROUND: Shoulder @entity1 is a common musculoskeletal symptom with a wide range of potential causes; however, the majority of conditions can be managed with conservative treatment. The aim of this study is to assess the efficacy and safety of Traumeel injections versus @entity2 injections and placebo in the treatment of @entity4 and @entity7 and expand the current evidence base for the conservative treatment of @entity4 . METHODS/DESIGN: This is a multi-center, randomized, double-blind, 16-week, three-arm, parallel-group, active- and placebo-controlled trial to assess the efficacy and safety of Traumeel 2 ml injection versus @entity3 8 mg injection versus placebo (saline solution). @entity0 will be randomly allocated to Traumeel, @entity3 or placebo in a 2:2:1 randomization. After 1 week screening, @entity0 will receive 3 injections at weekly intervals (days 1, 8 and 15) with additional follow-up assessments on day 22, a telephone consultation in week 9 and a final visit at week 15. Male and female @entity0 aged 40 to 65 years, inclusive, will be recruited if they have acute episodes of @entity4 and/or @entity7 . @entity0 with @entity5 in the shoulder joint or a complete rotator cuff tear will be excluded. At least 160 @entity0 will be recruited. All subacromial injections will be performed under ultrasound guidance utilizing a common technique. The only rescue medication permitted will be @entity6 ( @entity6 ), with usage recorded. The primary endpoint is change from baseline in abduction-rotation @entity1 visual analog scale (0-100 mm scale, 0 corresponds to no @entity1 and 100 to extreme @entity1 ) at day 22 (Traumeel injections versus @entity3 injections) for active external rotation. Secondary efficacy parameters include @entity8 , disability of arm, shoulder, hand score and @entity0 's/investigator's global assessment. Clinical efficacy will be assessed as non-inferiority of Traumeel with respect to @entity3 regarding the primary efficacy parameter. DISCUSSION: It is hoped that the results of this trial will expand the treatment options and evidence base available for the management of rotator cuff disease. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01702233 . EudraCT number: 2012-003393-12.

title: A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs XXXX injection in @entity4 : the TRAumeel in @entity4 (TRARO) study protocol.

answer: @entity3


abstract: BACKGROUND: Shoulder @entity1 is a common musculoskeletal symptom with a wide range of potential causes; however, the majority of conditions can be managed with conservative treatment. The aim of this study is to assess the efficacy and safety of Traumeel injections versus @entity2 injections and placebo in the treatment of @entity4 and @entity7 and expand the current evidence base for the conservative treatment of @entity4 . METHODS/DESIGN: This is a multi-center, randomized, double-blind, 16-week, three-arm, parallel-group, active- and placebo-controlled trial to assess the efficacy and safety of Traumeel 2 ml injection versus @entity3 8 mg injection versus placebo (saline solution). @entity0 will be randomly allocated to Traumeel, @entity3 or placebo in a 2:2:1 randomization. After 1 week screening, @entity0 will receive 3 injections at weekly intervals (days 1, 8 and 15) with additional follow-up assessments on day 22, a telephone consultation in week 9 and a final visit at week 15. Male and female @entity0 aged 40 to 65 years, inclusive, will be recruited if they have acute episodes of @entity4 and/or @entity7 . @entity0 with @entity5 in the shoulder joint or a complete rotator cuff tear will be excluded. At least 160 @entity0 will be recruited. All subacromial injections will be performed under ultrasound guidance utilizing a common technique. The only rescue medication permitted will be @entity6 ( @entity6 ), with usage recorded. The primary endpoint is change from baseline in abduction-rotation @entity1 visual analog scale (0-100 mm scale, 0 corresponds to no @entity1 and 100 to extreme @entity1 ) at day 22 (Traumeel injections versus @entity3 injections) for active external rotation. Secondary efficacy parameters include @entity8 , disability of arm, shoulder, hand score and @entity0 's/investigator's global assessment. Clinical efficacy will be assessed as non-inferiority of Traumeel with respect to @entity3 regarding the primary efficacy parameter. DISCUSSION: It is hoped that the results of this trial will expand the treatment options and evidence base available for the management of rotator cuff disease. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01702233 . EudraCT number: 2012-003393-12.

title: A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs @entity3 injection in XXXX : the TRAumeel in @entity4 (TRARO) study protocol.

answer: @entity4


abstract: BACKGROUND: Shoulder @entity1 is a common musculoskeletal symptom with a wide range of potential causes; however, the majority of conditions can be managed with conservative treatment. The aim of this study is to assess the efficacy and safety of Traumeel injections versus @entity2 injections and placebo in the treatment of @entity4 and @entity7 and expand the current evidence base for the conservative treatment of @entity4 . METHODS/DESIGN: This is a multi-center, randomized, double-blind, 16-week, three-arm, parallel-group, active- and placebo-controlled trial to assess the efficacy and safety of Traumeel 2 ml injection versus @entity3 8 mg injection versus placebo (saline solution). @entity0 will be randomly allocated to Traumeel, @entity3 or placebo in a 2:2:1 randomization. After 1 week screening, @entity0 will receive 3 injections at weekly intervals (days 1, 8 and 15) with additional follow-up assessments on day 22, a telephone consultation in week 9 and a final visit at week 15. Male and female @entity0 aged 40 to 65 years, inclusive, will be recruited if they have acute episodes of @entity4 and/or @entity7 . @entity0 with @entity5 in the shoulder joint or a complete rotator cuff tear will be excluded. At least 160 @entity0 will be recruited. All subacromial injections will be performed under ultrasound guidance utilizing a common technique. The only rescue medication permitted will be @entity6 ( @entity6 ), with usage recorded. The primary endpoint is change from baseline in abduction-rotation @entity1 visual analog scale (0-100 mm scale, 0 corresponds to no @entity1 and 100 to extreme @entity1 ) at day 22 (Traumeel injections versus @entity3 injections) for active external rotation. Secondary efficacy parameters include @entity8 , disability of arm, shoulder, hand score and @entity0 's/investigator's global assessment. Clinical efficacy will be assessed as non-inferiority of Traumeel with respect to @entity3 regarding the primary efficacy parameter. DISCUSSION: It is hoped that the results of this trial will expand the treatment options and evidence base available for the management of rotator cuff disease. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01702233 . EudraCT number: 2012-003393-12.

title: A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs @entity3 injection in @entity4 : the TRAumeel in XXXX (TRARO) study protocol.

answer: @entity4


abstract: INTRODUCTION AND OBJECTIVES: The @entity0 -finger transcription factor Kr  ppel-like factor 2 (KLF2) transduces blood flow into molecular signals responsible for a wide range of responses within the vasculature. KLF2 maintains a healthy, quiescent endothelial phenotype. Previous studies report a range of phenotypes following morpholino antisense oligonucleotide-induced @entity4 knockdown in @entity3 . Targeted genome editing is an increasingly applied method for functional assessment of candidate genes. We therefore generated a stable @entity4 mutant @entity3 and characterised its cardiovascular and haematopoietic development. METHODS AND RESULTS: Using Transcription Activator-Like Effector Nucleases (TALEN) we generated a @entity4 mutant (klf2ash317) with a 14bp deletion leading to a premature stop codon in exon 2. Western blotting confirmed loss of wild type @entity4 protein and the presence of a truncated protein in klf2ash317 mutants. Homozygous klf2ash317 mutants exhibit no defects in vascular patterning, survive to adulthood and are fertile, without displaying previously described morphant phenotypes such as high-output @entity2 , reduced haematopoetic stem cell (HSC) development or impaired formation of the 5th accessory aortic arch. Homozygous klf2ash317 mutation did not reduce angiogenesis in @entity3 with homozygous mutations in @entity1 ( @entity1 ), a form of angiogenesis that is dependent on blood flow. We examined expression of three klf family members in wildtype and klf2ash317 @entity3 . We detected vascular expression of @entity5 (but not @entity6 or @entity7 / @entity7 / @entity7 ) in wildtypes but found no differences in expression that might account for the lack of phenotype in klf2ash317 mutants. @entity5 morpholino knockdown did not affect heart rate or impair formation of the 5th accessory aortic arch in either wildtypes or klf2ash317 mutants. CONCLUSIONS: The klf2ash317 mutation produces a truncated @entity4 protein but, unlike morpholino induced @entity4 knockdown, does not affect cardiovascular development.

title: klf2ash317 Mutant XXXX Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.

answer: @entity3


abstract: UNASSIGNED: @entity7 ( @entity7 ) is a life-threatening @entity2 caused by gas-producing bacteria and fungi. It usually occurs in @entity0 with @entity1 and @entity0 with @entity8 . A combination of systemic antibiotics, percutaneous catheter drainage, or open nephrectomy is typically required to achieve cure. Because of grim prognosis, resorting to interventional methods is frequently inevitable. We report the case of a 77-year-old @entity0 with @entity1 and @entity4 on chronic hemodialysis that presented with @entity3 and @entity6 . A bubbly gas pattern inside the left kidney was demonstrated on abdominal computed tomography scan and blood cultures grew @entity5 . She was successfully treated solely with systemic antibiotics. This highlights the fact that prompt recognition of imaging findings associated with benign prognosis is essential for a favorable outcome. It allows for an effective management avoiding high-risk interventions, especially in frail @entity0 with multiple comorbidities. Finally, we review all published cases of @entity7 in chronic dialysis @entity0 .

title: Successful medical treatment of XXXX in chronic hemodialysis.

answer: @entity7


abstract: INTRODUCTION: @entity0 is heterogeneous, with different responses to NC even within similar histology and stages. OBJECTIVE: To evaluate clinical/pathological response to NC according to different @entity2 subtypes in Mexican @entity0 @entity1 . @entity1 AND METHODS: Retrospective study of @entity1 with @entity0 stages II-III, and complete immunohistochemistry (IHC), such as hormonal receptors @entity3 and Ki67, treated with NC and surgery. Descriptive and comparative analyses between different intrinsic subtypes were performed. RESULTS: A total of 117 @entity1 were included with 48.6    10.6 years of age, stage II (24%), and III (76%). We identified 20 (17.1%) cases of luminal A, 37 (31.6%) luminal B @entity3 -, 13 (11.1%) luminal B @entity3 +, 12 (10.3%) @entity3 +, and 35 (29.9%) triple negative. Clinical complete response ( @entity2 and lymph nodes) in luminal A was 10%, in luminal B @entity3 - 10.8%, luminal B @entity3 + 15.4%, @entity3 + 25%, and in triple negative 14.3%. Conservative surgeries were done in 9 (7.7%) @entity1 . There is a weak positive association between Ki67 expression and @entity2 clinical response. Pathological complete response occurred in 8 (6.83%) cases, being more frequent in luminal B @entity3 + @entity1 (23%). CONCLUSIONS: Pathological complete responses were more often in luminal B @entity3 + cases.

title: [Neoadjuvant Chemotherapy (NC) Response in @entity1 with XXXX According to Immunohistochemical Intrinsic Subtypes (IHC)].

answer: @entity0


abstract: INTRODUCTION: @entity0 is heterogeneous, with different responses to NC even within similar histology and stages. OBJECTIVE: To evaluate clinical/pathological response to NC according to different @entity2 subtypes in Mexican @entity0 @entity1 . @entity1 AND METHODS: Retrospective study of @entity1 with @entity0 stages II-III, and complete immunohistochemistry (IHC), such as hormonal receptors @entity3 and Ki67, treated with NC and surgery. Descriptive and comparative analyses between different intrinsic subtypes were performed. RESULTS: A total of 117 @entity1 were included with 48.6    10.6 years of age, stage II (24%), and III (76%). We identified 20 (17.1%) cases of luminal A, 37 (31.6%) luminal B @entity3 -, 13 (11.1%) luminal B @entity3 +, 12 (10.3%) @entity3 +, and 35 (29.9%) triple negative. Clinical complete response ( @entity2 and lymph nodes) in luminal A was 10%, in luminal B @entity3 - 10.8%, luminal B @entity3 + 15.4%, @entity3 + 25%, and in triple negative 14.3%. Conservative surgeries were done in 9 (7.7%) @entity1 . There is a weak positive association between Ki67 expression and @entity2 clinical response. Pathological complete response occurred in 8 (6.83%) cases, being more frequent in luminal B @entity3 + @entity1 (23%). CONCLUSIONS: Pathological complete responses were more often in luminal B @entity3 + cases.

title: [Neoadjuvant Chemotherapy (NC) Response in XXXX with @entity0 According to Immunohistochemical Intrinsic Subtypes (IHC)].

answer: @entity1


abstract: OBJECTIVES/HYPOTHESIS: To determine the diagnostic value of @entity4 positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal @entity1 in @entity0 with @entity5 (SCC) with @entity3 and to assess the role of PET-CT as a supplement to CT/MR. STUDY DESIGN: Retrospective analysis. METHODS: A total of 39 @entity0 with @entity3 (36 @entity0 and 3 @entity0 ; average age 65.4 years) underwent @entity2 resection and neck dissection as primary treatment. All @entity0 were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. RESULTS: Twenty (51.3%) of the 39 @entity0 were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six @entity0 who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. CONCLUSIONS: The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal @entity1 in @entity0 with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

title: @entity4 PET-CT as a supplement to CT/MRI for detection of nodal XXXX in hypopharyngeal SCC with @entity3 .

answer: @entity1


abstract: OBJECTIVES/HYPOTHESIS: To determine the diagnostic value of @entity4 positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal @entity1 in @entity0 with @entity5 (SCC) with @entity3 and to assess the role of PET-CT as a supplement to CT/MR. STUDY DESIGN: Retrospective analysis. METHODS: A total of 39 @entity0 with @entity3 (36 @entity0 and 3 @entity0 ; average age 65.4 years) underwent @entity2 resection and neck dissection as primary treatment. All @entity0 were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. RESULTS: Twenty (51.3%) of the 39 @entity0 were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six @entity0 who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. CONCLUSIONS: The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal @entity1 in @entity0 with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

title: XXXX PET-CT as a supplement to CT/MRI for detection of nodal @entity1 in hypopharyngeal SCC with @entity3 .

answer: @entity4


abstract: OBJECTIVES/HYPOTHESIS: To determine the diagnostic value of @entity4 positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal @entity1 in @entity0 with @entity5 (SCC) with @entity3 and to assess the role of PET-CT as a supplement to CT/MR. STUDY DESIGN: Retrospective analysis. METHODS: A total of 39 @entity0 with @entity3 (36 @entity0 and 3 @entity0 ; average age 65.4 years) underwent @entity2 resection and neck dissection as primary treatment. All @entity0 were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. RESULTS: Twenty (51.3%) of the 39 @entity0 were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six @entity0 who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. CONCLUSIONS: The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal @entity1 in @entity0 with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

title: @entity4 PET-CT as a supplement to CT/MRI for detection of nodal @entity1 in hypopharyngeal SCC with XXXX .

answer: @entity3


abstract: OBJECTIVE: Duplex ultrasonography (DUS) has been the mainstay for diagnosing @entity2 and is often the sole diagnostic modality used prior to intervention. Highly calcified plaque, however, results in an acoustic shadow (AcS) that obscures the vessel lumen and inhibits the sonographer's ability to obtain Doppler velocity measurements. It is unknown whether DUS can accurately determine the degree of @entity2 in these settings. METHODS: From July 2012 to December 2013, all @entity0 with AcS on DUS measuring >= 5  mm in the @entity5 were cross-referenced with multidetector computed tomographic angiography ( @entity3 -CTA) images of the neck to define the study population. After standardizing the @entity3 -CTA windows, percent @entity4 was determined by cross-sectional area reduction using two separate previously described methods based on North American Symptomatic Carotid Endarterectomy Trial (NASCET) and European Carotid Surgery Trial (ECST) criteria. DUS waveform parameters in the internal carotid artery near the AcS were then compared with these @entity3 -CTA measurements to determine the accuracy of DUS in characterizing the severity of @entity2 . RESULTS: During this period, 8517 DUS studies were performed at the Massachusetts General Hospital, 550 of which had AcS, for an incidence of 6.45%. There were 92 lesions with a concomitant @entity3 -CTA; however, seven were excluded because of poor study quality, because >= 6  months had elapsed between DUS and @entity3 -CTA, or because the @entity0 had undergone carotid reconstruction between studies. Of the 85 remaining lesions, DUS characterized 17 as severe (peak systolic velocity [PSV] >250  cm/s), 31 as moderate (PSV  = 151-250  cm/s), and 37 as mild (PSV  <=150  cm/s) stenoses using PSV criteria. PSV weakly correlated with CTA-NASCET (r  = 0.361; P  = .004) and CTA-ECST (r  = 0.306; P  = .004) percent @entity4 . Using PSV >250  cm/s as the predictor of >70% @entity4 , and a >= 70% cutoff by both CTA-ECST and CTA-NASCET methods as the reference measure, DUS sensitivity ranged from 22.7% to 32.5%, specificity from 89.4% to 91.1%, positive predictive value from 88.2% to 76.4%, and negative predictive value from 25% to 60.2%. A subgroup analysis of lesions identified as non-severe by DUS revealed that waveforms with lower deceleration were associated with severe @entity4 on CTA. CONCLUSIONS: In the presence of AcS, DUS alone is inadequate to accurately determine the degree of @entity2 with sensitivity, specificity, and negative predictive values far below that needed for clinical decision-making. @entity3 -CTA may be necessary for improved characterization of plaque in these @entity1 . Further studies are needed to determine DUS parameters that may identify @entity0 who should undergo further evaluation with @entity3 -CTA to characterize the true severity of the @entity4 .

title: Acoustic shadowing impairs accurate characterization of XXXX in carotid ultrasound examinations.

answer: @entity4


abstract: UNASSIGNED: Aim   The current study aimed to assess the perinatal risk of @entity7 ( @entity7 ) and to establish a suitable surgical strategy in consideration of postoperative lung growth and problems during adulthood. Methods   Among 874 @entity7 @entity0 identified in a nationwide survey, 428 @entity0 were born between 1992 and 2012 and treated at 10 high-volume centers were retrospectively reviewed with statistical analysis. Results   In the 194 @entity0 who were prenatally diagnosed to have @entity7 , 16.7% presented with fetal hydrops as observed using ultrasonography. The Apgar score (5 minutes) was lower than 5 in 5.4%. As of postnatal day 30, 14.0% of the neonatal @entity0 required respiratory support, and 3.3% (8/243) had died because of @entity4 . Among those who were asymptomatic immediately after birth, 33.6% of the @entity0 developed the @entity6 during their first year of life, and 22.1% did so between the age of 1 and 2 years. The postoperative percent vital capacity among the prenatally diagnosed @entity0 was significantly higher than that among the postnatally diagnosed @entity0 (98.3        11.9 vs. 81.7        9.7, p   <   0.0222). Late complications included @entity2 in 30 @entity0 and persistent @entity4 in 4 @entity0 , whereas @entity1 was not observed in the present series. Conclusions   Approximately 10 to 15% of prenatally diagnosed @entity7 @entity0 may carry a high risk of perinatal @entity5 . Early operation before developing episodes of @entity4 , seem to be associated with a better development of the reserved lung during later life. The incidence of @entity3 among @entity0 with @entity7 may be extremely low.

title: Clinical Features of XXXX : A Report on a Nationwide Multicenter Study in Japan.

answer: @entity7


abstract: INTRODUCTION: In @entity1 @entity0 it is useful to measure skeletal muscle forces. Conventional methods require voluntary muscle activation, which can be unreliable. We evaluated a device for non-voluntary force assessment. METHODS: We tested 8 @entity0 (unknown @entity1 n = 2, @entity6 , @entity5 , @entity4 , @entity7 , multi-minicore disease, @entity3 , n = 1 each). Isometric twitch torques of ankle dorsiflexors were measured after fibular nerve stimulation. RESULTS: Six @entity0 had decreased torques vs. 8 controls ( @entity0 : median Newton-meter 1.6 vs 5.7, @entity0 : 0.2 vs 3.9, both P   <   0.0001). Values correlated with Manual Muscle Test results (r = 0.73, r(2) = 0.53, P   <   0.0001). In weak dorsiflexors, torque could be measured despite lower signal-to-noise ratio. In 2 @entity0 with @entity2 we measured increased torques. DISCUSSION: Non-voluntary muscle force assessment can be used in @entity0 with @entity1 , and values correlate with voluntary forces determined by traditional methods. This article is protected by copyright. All rights reserved.

title: Isometric skeletal muscle force measurement in primary XXXX .

answer: @entity1


abstract: UNASSIGNED: A variety of skilled reaching tasks have been developed to evaluate forelimb function in rodent models. The single pellet skilled reaching task and pasta matrix task have provided valuable insight into recovery of forelimb function in models of @entity0 and disease. Recently, several automated measures have been developed to reduce the cost and time burden of forelimb assessment in rodents. Here, we provide a within-subject comparison of three common forelimb assessments to allow direct evaluation of sensitivity and efficiency across tasks. @entity1 were trained to perform the single pellet skilled reaching task, the pasta matrix task, and the isometric pull task. Once proficient on all three tasks, @entity1 received an ischemic lesion of motor cortex and striatum to impair use of the trained limb. On the second week post-lesion, all three tasks measured a significant @entity2 . Performance was well-correlated across tasks. By the sixth week post-lesion, only the isometric pull task measured a significant @entity2 , suggesting that this task is more sensitive to @entity3 . The number of training days required to reach asymptotic performance was longer for the isometric pull task, but the total experimenter time required to collect and analyze data was substantially lower. These findings suggest that the isometric pull task represents an efficient, sensitive measure of forelimb function to facilitate preclinical evaluation in models of @entity0 and disease.

title: A Within-Animal Comparison of Skilled Forelimb Assessments in XXXX .

answer: @entity1


abstract: AIM: The main objective of this study is to demonstrate whether @entity4 metabolism alterations identified in @entity0 with advanced @entity2 show any improvement after liver transplant. METHODS: The study included 86 @entity0 who underwent liver transplant between March 2010 and February 2011. An oral @entity3 tolerance test was performed before the liver transplant, and 6 and 12 months after. Beta cell function and @entity5 resistance were also calculated, applying formulae that use basal plasma glycaemia and @entity5 , and plasma glycaemia and @entity5 during an oral @entity3 tolerance test. Risk factors for pre- and post-transplant @entity1 were also studied. The diagnosis of @entity1 was based on an OGTT. RESULTS: The proportion of @entity0 with @entity1 before transplant, and at month 6 and 12 after transplant were 70.9%, 48.8% and 39.2%, respectively. Compared to baseline, at month 6 the odds ratio of having @entity1 was 0.39 (IC 95% [0.21, 0.73]) and at month 12 it was 0.26 (IC 95% [0.14, 0.50]). The composite @entity5 sensitivity index values at 6 and 12 months were 1.72 units higher (IC 95% [0.84, 2.58]) and 1.58 units higher (IC 95% [0.68, 2.44)] than baseline. A statistically significant association was found between high MELD values and high body mass index, and risk of pre-transplant @entity1 (p=0.001 and p=0.033, respectively). @entity2 aetiology did not influence the risk of @entity1 . CONCLUSIONS: In this study, we were able to ascertain that alterations in @entity4 metabolism typical of advanced @entity2 improve after liver transplant. This improvement is mainly due to an improvement in @entity5 resistance.

title: Alterations in XXXX metabolism in cirrhotic @entity0 before and after liver transplant.

answer: @entity4


abstract: AIM: The main objective of this study is to demonstrate whether @entity4 metabolism alterations identified in @entity0 with advanced @entity2 show any improvement after liver transplant. METHODS: The study included 86 @entity0 who underwent liver transplant between March 2010 and February 2011. An oral @entity3 tolerance test was performed before the liver transplant, and 6 and 12 months after. Beta cell function and @entity5 resistance were also calculated, applying formulae that use basal plasma glycaemia and @entity5 , and plasma glycaemia and @entity5 during an oral @entity3 tolerance test. Risk factors for pre- and post-transplant @entity1 were also studied. The diagnosis of @entity1 was based on an OGTT. RESULTS: The proportion of @entity0 with @entity1 before transplant, and at month 6 and 12 after transplant were 70.9%, 48.8% and 39.2%, respectively. Compared to baseline, at month 6 the odds ratio of having @entity1 was 0.39 (IC 95% [0.21, 0.73]) and at month 12 it was 0.26 (IC 95% [0.14, 0.50]). The composite @entity5 sensitivity index values at 6 and 12 months were 1.72 units higher (IC 95% [0.84, 2.58]) and 1.58 units higher (IC 95% [0.68, 2.44)] than baseline. A statistically significant association was found between high MELD values and high body mass index, and risk of pre-transplant @entity1 (p=0.001 and p=0.033, respectively). @entity2 aetiology did not influence the risk of @entity1 . CONCLUSIONS: In this study, we were able to ascertain that alterations in @entity4 metabolism typical of advanced @entity2 improve after liver transplant. This improvement is mainly due to an improvement in @entity5 resistance.

title: Alterations in @entity4 metabolism in cirrhotic XXXX before and after liver transplant.

answer: @entity0


abstract: Current @entity4 ( @entity4 ) focuses on preventing secondary @entity3 -a leading cause of mortality-by regularly cleaning and bandaging blisters and @entity5 and preventive bandaging of high-friction areas. Unfortunately the baths and showers used to remove bandages and clean the skin are often @entity1 , causing lack of adherence and subsequent increases in @entity3 , @entity1 , and antimicrobial use. This study evaluates the hypothesis that bathing individuals with @entity4 in saltwater is less @entity1 than in normal bath water. The study also explores whether taking saltwater baths reduces @entity3 as measured through skin pruritus, odor, discharge, and nonbathing @entity1 . @entity0 recruited from the @entity0 's Hospital Colorado Outpatient @entity4 Clinic completed standardized questionnaires assessing the effects of the clinic's saltwater bathing recommendations; the data were analyzed using frequencies and Fisher tests. After starting saltwater baths, @entity0 reported a significant reduction in @entity1 (91%), @entity1 medication use (66%), skin odor (31%), and skin discharge (44%). No significant differences were found with respect to the type of @entity4 , age, length of time using baths, or amount of salt added. Saltwater baths are a noninvasive, low-cost, effective treatment that significantly reduces @entity1 , @entity1 medication use, and some signs of @entity2 . This treatment can be recommended to @entity0 with all studied @entity4 types without regard to age, the specific amount of salt used, bathing frequency, or @entity1 level. Given the central role bathing and dressing changes play in the management of @entity4 , the use of saltwater baths can lead to significant improvement in quality of life.

title: Effectiveness of saltwater baths in the treatment of XXXX .

answer: @entity4


abstract: BACKGROUND AND OBJECTIVES: When surgery is not adequate or feasible, stereotactic body radiotherapy (SBRT) reirradiation has been used for recurrent @entity1 . We report the outcomes of a series of @entity0 with pelvic recurrences from @entity2 reirradiated with SBRT. METHODS: The Cyberknife(TM) Robotic Stereotactic Radiosurgery system with fiducial based real time tracking was used. @entity0 were followed with imaging of the pelvis. RESULTS: Four @entity0 and 14 @entity0 with 22 lesions were included. The mean dose was 25   Gy in median of five fractions. The mean prescription isodose was 77%, with a median maximum dose of 32.87   Gy. There were two local failures, with a crude local control rate of 89%. The median overall survival was 43 months. One @entity0 had @entity4 and required surgery (Grade IV), two @entity0 had symptomatic @entity3 (1 Grade III) and one @entity0 developed @entity6 from ureteric @entity5 requiring a stent (Grade III). CONCLUSIONS: Local recurrence in the pelvis after modern combined modality treatment for @entity2 is rare. However it presents a therapeutic dilemma when it occurs; often symptomatic and eventually life threatening. SBRT can be a useful non-surgical modality to control pelvic recurrences after prior radiation for @entity2 . J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Stereotactic body radiotherapy (SBRT) reirradiation for pelvic recurrence from XXXX .

answer: @entity2


abstract: UNASSIGNED: Severe GN involves local neutrophil extracellular @entity8 (NET) formation. We hypothesized a local cytotoxic effect of NET-related histone release in @entity2 GN. In vitro, histones from @entity4 thymus or histones released by neutrophils undergoing NETosis killed glomerular endothelial cells, podocytes, and parietal epithelial cells in a dose-dependent manner. Histone-neutralizing agents such as antihistone IgG, activated protein C, or heparin prevented this effect. Histone @entity3 on glomeruli ex vivo was @entity7 dependent, and lack of @entity7 attenuated histone-induced renal @entity6 and @entity0 in mice. Anti-glomerular basement membrane GN involved NET formation and vascular @entity2 , whereas blocking NET formation by peptidylarginine inhibition or preemptive anti-histone IgG injection significantly reduced all aspects of GN (i.e., vascular @entity2 , podocyte loss, @entity5 , cytokine induction, recruitment or activation of glomerular leukocytes, and glomerular crescent formation). To evaluate histones as a therapeutic target, @entity1 with established GN were treated with three different histone-neutralizing agents. Anti-histone IgG, recombinant activated protein C, and heparin were equally effective in abrogating severe GN, whereas combination therapy had no additive effects. Together, these results indicate that NET-related histone release during GN elicits cytotoxic and immunostimulatory effects. Furthermore, neutralizing extracellular histones is still therapeutic when initiated in established GN.

title: Neutrophil Extracellular XXXX -Related Extracellular Histones Cause Vascular Necrosis in Severe GN.

answer: @entity8


abstract: UNASSIGNED: INTRODUCTION @entity5 ( @entity5 ) frequently coexists with other @entity1 . OBJECTIVES The aim of this study was to assess the prevalence of @entity5 in outpatients with stable @entity2 ( @entity2 ), and to determine clinical and laboratory correlates of this @entity4 . Further, we compared the indications for antithrombotic therapy using the older CHADS2 and the modern CHA2DS2-VASc score. @entity0 AND METHODS We investigated a representative sample of 2578 Polish @entity0 with stable @entity2 participating in the multicenter RECENT study (age: 65  10 years; @entity0 : 55%; CCS class I/II/III+IV: 38/48/14%). RESULTS @entity5 was present in 19% of @entity0 with @entity2 . Advanced age, the longer history of @entity2 , and concomitant @entity3 were independently associated with the higher prevalence of @entity5 (all P<0.05). Among @entity0 with @entity2 and @entity5 , according to the CHADS2 score 73% of subjects required antithrombotic therapy (score >= 2) and according to the CHA2DS2-VASc score - 94% (score >= 2). 47% of @entity0 with the CHADS2 score of 0 and 85% with the CHADS2 score of 1 had the CHA2DS2-VASc score >= 2. Therefore, 21% of @entity0 with @entity2 and @entity5 did not have strong indications for antithrombotic therapy according to the CHADS2 score (0-1), while they required oral anticoagulation based on the CHA2DS2-VASc score (>= 2). CONCLUSIONS @entity5 affects every fifth @entity2 @entity0 . According to CHA2DS2-VASc score almost all @entity0 with @entity2 and @entity5 require antithrombotic management, which can complicate coronary revascularization and make the related antiplatelet therapy challenging.

title: XXXX in outpatients with stable @entity2 - results from multicenter RECENT study.

answer: @entity5


abstract: UNASSIGNED: INTRODUCTION @entity5 ( @entity5 ) frequently coexists with other @entity1 . OBJECTIVES The aim of this study was to assess the prevalence of @entity5 in outpatients with stable @entity2 ( @entity2 ), and to determine clinical and laboratory correlates of this @entity4 . Further, we compared the indications for antithrombotic therapy using the older CHADS2 and the modern CHA2DS2-VASc score. @entity0 AND METHODS We investigated a representative sample of 2578 Polish @entity0 with stable @entity2 participating in the multicenter RECENT study (age: 65  10 years; @entity0 : 55%; CCS class I/II/III+IV: 38/48/14%). RESULTS @entity5 was present in 19% of @entity0 with @entity2 . Advanced age, the longer history of @entity2 , and concomitant @entity3 were independently associated with the higher prevalence of @entity5 (all P<0.05). Among @entity0 with @entity2 and @entity5 , according to the CHADS2 score 73% of subjects required antithrombotic therapy (score >= 2) and according to the CHA2DS2-VASc score - 94% (score >= 2). 47% of @entity0 with the CHADS2 score of 0 and 85% with the CHADS2 score of 1 had the CHA2DS2-VASc score >= 2. Therefore, 21% of @entity0 with @entity2 and @entity5 did not have strong indications for antithrombotic therapy according to the CHADS2 score (0-1), while they required oral anticoagulation based on the CHA2DS2-VASc score (>= 2). CONCLUSIONS @entity5 affects every fifth @entity2 @entity0 . According to CHA2DS2-VASc score almost all @entity0 with @entity2 and @entity5 require antithrombotic management, which can complicate coronary revascularization and make the related antiplatelet therapy challenging.

title: @entity5 in outpatients with stable XXXX - results from multicenter RECENT study.

answer: @entity2


abstract: 53 @entity0 implanted subcutaneously into C57BL/6- @entity2 were examined. The animals were killed at various stages of @entity1 ( @entity1 ) and prepared for histology and for scanning electron microscopy (critical-point-dried tissue; vascular corrosion casts). Prior to casting animals were rinsed using different perfusion pressures. Casting was done by manual injection of the resin, whereby different influx-rates were applied resulting in low, medium and high pressure preparations. We discern 3 phases of @entity1 angiogenesis (TA) occurring during 4 stages of @entity1 among which vasodilation establishes the first reaction of the host vascular system to a growing @entity1 implant. During this stage 1 of @entity1 , @entity1 nidation, nearby sinusoidal dilated host capillaries form globular outgrowings (phase 1 of TA). Subsequently radially arranged sprouts, which preferentially arise from venous host vessels, grow into the centre of the implant (phase 2 of TA). Stage 2 of @entity1 , early @entity1 , is characterized by @entity3 tissue and the development of a central avascular cavity. Thus the @entity1 vascular system is organized like a hollow sphere with a central cavity and a peripheral vascular "envelope" with large vessels embracing the @entity1 and centrifugally growing vascular sprouts, which arise from the venous part of the vascular "envelope" and invade the surrounding host tissue (phase 3 of TA). During stage 3 of @entity1 , late @entity1 , many vessels of the basket-like vascular "envelope" obliterate. In stage 4 of @entity1 , prefinal phase, the peripheral vascular density decreases continuously. Thus vascular sprouting and proliferation of viable @entity1 cells is confined to basal regions of the @entity1 .

title: The angioarchitecture of the XXXX in laboratory @entity2 (a light microscopic and scanning electron microscopic study).

answer: @entity0


abstract: 53 @entity0 implanted subcutaneously into C57BL/6- @entity2 were examined. The animals were killed at various stages of @entity1 ( @entity1 ) and prepared for histology and for scanning electron microscopy (critical-point-dried tissue; vascular corrosion casts). Prior to casting animals were rinsed using different perfusion pressures. Casting was done by manual injection of the resin, whereby different influx-rates were applied resulting in low, medium and high pressure preparations. We discern 3 phases of @entity1 angiogenesis (TA) occurring during 4 stages of @entity1 among which vasodilation establishes the first reaction of the host vascular system to a growing @entity1 implant. During this stage 1 of @entity1 , @entity1 nidation, nearby sinusoidal dilated host capillaries form globular outgrowings (phase 1 of TA). Subsequently radially arranged sprouts, which preferentially arise from venous host vessels, grow into the centre of the implant (phase 2 of TA). Stage 2 of @entity1 , early @entity1 , is characterized by @entity3 tissue and the development of a central avascular cavity. Thus the @entity1 vascular system is organized like a hollow sphere with a central cavity and a peripheral vascular "envelope" with large vessels embracing the @entity1 and centrifugally growing vascular sprouts, which arise from the venous part of the vascular "envelope" and invade the surrounding host tissue (phase 3 of TA). During stage 3 of @entity1 , late @entity1 , many vessels of the basket-like vascular "envelope" obliterate. In stage 4 of @entity1 , prefinal phase, the peripheral vascular density decreases continuously. Thus vascular sprouting and proliferation of viable @entity1 cells is confined to basal regions of the @entity1 .

title: The angioarchitecture of the @entity0 in laboratory XXXX (a light microscopic and scanning electron microscopic study).

answer: @entity2