abstract: BACKGROUND: Hospital acquired infections worsen the outcome of @entity0 treated in intensive care units and are costly. Coatings with @entity2 or metal alloys may reduce or alter the formation of biofilm on invasive medical devices. An endotracheal tube (ETT) is used to connect the @entity0 to a ventilator and coated tubes have been tested in relation to bacterial colonization and @entity4 . In the present study, we aimed to evaluate and compare a coated and uncoated ETT for @entity0 symptoms and local tracheal tolerability during short term clinical use. Degree of bacterial colonization was also described. METHODS: A @entity2 - @entity6 -gold alloy coating ('Bactiguard  'Infection Protection, @entity3 ) has been extensively used on urinary tract catheters and lately also on central venous catheters. We performed a randomised, single-blinded, controlled, first in @entity0 , post Conformit   Europ  enne (EC) certification and CE marking study, focused on Bactiguard   coated ETTs ( @entity3 ETT). Thirty @entity0 at a tertiary university hospital scheduled for upper abdominal elective surgery with an expected duration of anaesthesia of at least 3  h were randomised; @entity3 ETT (n   =   20) or standard ETT (n   =   10). The tolerability was assessed with a modified version of Quality of Life Head and Neck Module, QLQ-H_N35 and by inspection of the tracheal mucosa with a fibre-optic bronchoscope before intubation and at extubation. Adverse Events (AE) and bacterial adherence were also studied. Statistical evaluations were carried out with the Fisher's Exact Test, the Clopper-Pearson method, as well as a Proportional Odds Model. RESULTS: Differences between groups were identified in 2 of 8 @entity0 related symptoms with regard to tolerability by QLQ-H_N35 (cough, p   =   0.022 and @entity5 , p   =   0.014 in the treatment group.). No @entity1 was identified with bronchoscopy. A low level of bacterial colonization with normal flora, equal between groups, was seen after short-term of intubation (median 5  h). No serious Adverse Events related to the use of an ETT were observed. The results should be treated with caution due to statistical confounders, a small study size and large inter-individual variability in bacterial adhesion. CONCLUSIONS: The new device @entity3 ETT is well tolerated and has good clinical performance during short-term intubation. Studies with larger sample sizes and longer intubation periods (>24  h) in the ICU-setting are needed and can now be planned in order to identify possible differences in clinical outcomes. TRIAL REGISTRATION: Registered in ClinicalTrials.gov, REGISTRATION NUMBER: NCT01682486 , Date of Registration: August, 30, 2012.

title: Tolerability and performance of XXXX endotracheal tubes with noble metal alloy coating - a randomized clinical evaluation study.

answer: @entity3


abstract: BACKGROUND: Bariatric procedures provide an effective means of short term weight loss and sustained weight control for the morbidly @entity1 . The effect of bariatric procedures on smoking habit in @entity1 subjects is not well known. Therefore, we examined the short term effect of bariatric surgery on smoking habit of severe @entity1 @entity0 up to 12  months from the intervention. @entity0 AND METHODS: Smoking habit was assessed in a cohort of 78 morbid smoking @entity1 @entity0 followed at our clinic for bariatric procedures. They underwent non surgical intra-gastric balloon (IB) or surgical procedures such as lap-band laparoscopic surgery (LAGB) or sleeve gastrectomy/gastric by-pass (SPG). Subjects were administered a written questionnaire about their smoking habit before and 3, 6 and 12  months after the procedures. RESULTS: No differences were found among the three groups at 6 and 12  months after the procedures (IB 21  %, LAGB 6  %, SPG 5  %; and IB 14  %, LAGB 3  %, SPG 5  %). Only after 3  months, the rate of quitting of the IB group was higher than LAGB and SPG groups (36  %, 6  % and 5  %, respectively; p   =   0.02). CONCLUSIONS: Bariatric procedures have no effects on smoking habit of moderate-to-heavy smoker severe @entity1 @entity0 . The use of other traditional smoking cessation methods in @entity0 undergone to bariatric procedures should be implemented.

title: Smoking Habit in Severe XXXX after bariatric procedures.

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity6 ) is a precursor of various lipid mediators. @entity6 metabolites such as @entity4 cause @entity2 and vasoconstriction, thus may lead to @entity1 . It is unclear whether dietary @entity6 influences the @entity6 -derived lipid mediator balance and the risk for @entity1 , such as @entity5 . Considering the function of @entity6 in @entity1 , it is reasonable to focus on the atherothrombotic type of @entity5 risk. However, no systematic reviews or meta-analyses have been conducted to evaluate the effect of habitual @entity6 exposure on @entity5 risk. We aimed to systematically evaluate observational studies available on the relationship between @entity6 exposure and the atherothrombotic type of @entity5 risk in free-living populations. SUMMARY: The PubMed database was searched for articles registered up to June 24, 2014. We designed a PubMed search formula as follows: key words for @entity0 AND @entity5 AND study designs AND @entity6 exposure. Thirty-three articles were reviewed against predefined criteria. There were 695 bibliographies assessed from the articles that included both @entity6 and @entity5 descriptions. Finally, we identified 11 eligible articles and categorized them according to their reporting and methodological quality. We used the Strengthening the Reporting of Observational Studies in Epidemiology Statement (STROBE) checklist to score the reporting quality. The methodological quality was qualitatively assessed based on the following aspects: subject selection, @entity6 exposure assessment, outcome diagnosis, methods for controlling confounders, and statistical analysis. We did not conduct a meta-analysis due to the heterogeneity among the studies. All eligible studies measured blood @entity6 levels as an indicator of exposure. Our literature search did not identify any articles that evaluated dietary @entity6 intake and tissue @entity6 as assessments of exposure. Seven of the 11 eligible articles were considered to be of low quality. No articles reported a dose-dependent positive association between an increased @entity5 risk and @entity6 exposure. However, most studies did not assess the risk in each subtype of @entity5 , thus various etiological types of @entity5 risk were involved in their results. KEY MESSAGES: We did not find a positive association between @entity6 exposure and @entity5 risk. Eligible studies reported inconsistent findings: @entity5 risk did not change or significantly decreased. We could not draw any conclusions due to the limited number of eligible high-quality studies. Further evidence from well-designed observational studies is required. Simultaneously, in order to develop effective preventive measures against @entity5 , it is imperative to establish standardized definitions, nomenclatures, classifications, and diagnostic procedures.

title: @entity3 and XXXX Risk: A Systematic Review of Observational Studies.

answer: @entity5


abstract: BACKGROUND: @entity3 ( @entity6 ) is a precursor of various lipid mediators. @entity6 metabolites such as @entity4 cause @entity2 and vasoconstriction, thus may lead to @entity1 . It is unclear whether dietary @entity6 influences the @entity6 -derived lipid mediator balance and the risk for @entity1 , such as @entity5 . Considering the function of @entity6 in @entity1 , it is reasonable to focus on the atherothrombotic type of @entity5 risk. However, no systematic reviews or meta-analyses have been conducted to evaluate the effect of habitual @entity6 exposure on @entity5 risk. We aimed to systematically evaluate observational studies available on the relationship between @entity6 exposure and the atherothrombotic type of @entity5 risk in free-living populations. SUMMARY: The PubMed database was searched for articles registered up to June 24, 2014. We designed a PubMed search formula as follows: key words for @entity0 AND @entity5 AND study designs AND @entity6 exposure. Thirty-three articles were reviewed against predefined criteria. There were 695 bibliographies assessed from the articles that included both @entity6 and @entity5 descriptions. Finally, we identified 11 eligible articles and categorized them according to their reporting and methodological quality. We used the Strengthening the Reporting of Observational Studies in Epidemiology Statement (STROBE) checklist to score the reporting quality. The methodological quality was qualitatively assessed based on the following aspects: subject selection, @entity6 exposure assessment, outcome diagnosis, methods for controlling confounders, and statistical analysis. We did not conduct a meta-analysis due to the heterogeneity among the studies. All eligible studies measured blood @entity6 levels as an indicator of exposure. Our literature search did not identify any articles that evaluated dietary @entity6 intake and tissue @entity6 as assessments of exposure. Seven of the 11 eligible articles were considered to be of low quality. No articles reported a dose-dependent positive association between an increased @entity5 risk and @entity6 exposure. However, most studies did not assess the risk in each subtype of @entity5 , thus various etiological types of @entity5 risk were involved in their results. KEY MESSAGES: We did not find a positive association between @entity6 exposure and @entity5 risk. Eligible studies reported inconsistent findings: @entity5 risk did not change or significantly decreased. We could not draw any conclusions due to the limited number of eligible high-quality studies. Further evidence from well-designed observational studies is required. Simultaneously, in order to develop effective preventive measures against @entity5 , it is imperative to establish standardized definitions, nomenclatures, classifications, and diagnostic procedures.

title: XXXX and @entity5 Risk: A Systematic Review of Observational Studies.

answer: @entity3


abstract: BACKGROUND: Acute exacerbation of @entity2 (AECOPD) is a common cause of hospitalization and mortality. Recent studies have shown the usefulness of eosinopenia in predicting the outcomes of @entity0 admitted to the intensive care unit. This study examined the association of eosinopenia with the outcomes of @entity0 with AECOPD. METHODS: This is a prospective study. @entity0 with AECOPD were divided into two cohorts: @entity0 with eosinopenia and those without eosinopenia. Duration of hospitalization, need of mechanical ventilation, in-hospital mortality, rehospitalization, or @entity1 within 30 days after discharge were compared between the two cohorts. Eosinopenia was defined as eosinophil count of >40 cells/mm(3). RESULTS: Among 100 @entity0 with AECOPD, 44 were eosinopenic and 56 were non-eosinopenic. Duration of hospitalization of @entity0 with eosinopenia was 12.38    9.85 days and that of @entity0 without eosinopenia was 7.35    5.68 days (p = 0.001). In all, 16 (36%) @entity0 with eosinopenia and seven (12%) @entity0 without eosinopenia needed mechanical ventilation (p = 0.005). In-hospital mortality rate among eosinopenic and noneosinopenic @entity0 was 37.5% (12/44) and 7.6% (4/56), respectively (p = 0.006). Among 100 @entity0 with AECOPD, 16 died in the hospital. Of these, 12 (27.27%) were eosinopenic and 4 (7.6%) were noneosinopenic (p = 0.006). The mean eosinophil count of @entity0 who died in the hospital (n = 16) was 44.00 cells/ml whereas that of survivors (n = 84) was 107.41 cells/ml (p = 0.022). CONCLUSION: We conclude that a significant relationship exists between eosinopenia and outcomes of @entity0 with AECOPD. Thus, eosinopenia can be a useful, easy-to-measure, and inexpensive biomarker for predicting the prognosis of @entity0 with AECOPD.

title: Eosinopenia as a Marker of Outcome in Acute Exacerbations of XXXX .

answer: @entity2


abstract: 139 limbs from embalmed specimens were dissected to reveal the attachments of extensor muscles in the vicinity of the lateral epicondyle. M. extensor carpi radialis brevis was found to consist of a keel-shaped tendon with attachments to m. extensor carpi radialis longus, m. extensor digitorum communis, m. supinator; and to the radial collateral ligament, the orbicular ligament, the capsule of the @entity3 . On 29 limbs, a prolongation of the muscle was identified attaching proximal to the lateral epicondyle. On nine specimens a bursa was evident between the capsule over the head of the radius and the overlying soft tissues. There was no evidence of variation in vascular or nerve supply to the region. Examination of m. extensor carpi radialis brevis while under tension across the elbow, forearm and wrist revealed the greatest muscle lengthening in pronation of the forearm with @entity4 . The results of this study support the hypothesis that @entity2 is primarily a mechanically-induced condition. When performing movements at the wrist, with the forearm in pronation, the muscle is at its maximum length. As its origin lies proximal to the @entity1 for flexion and extension at the elbow, it is subject to shearing stress in all movements of the forearm, especially those involving power at the wrist. This is further compounded by the head of the radius rotating anteriorly against m. extensor carpi radialis brevis during pronation of the forearm. Additionally, a number of individuals may experience @entity0 at the head of the radius during pronation, due to irritation of an underlying bursa.

title: XXXX . A review of structures associated with @entity2 .

answer: @entity2


abstract: 139 limbs from embalmed specimens were dissected to reveal the attachments of extensor muscles in the vicinity of the lateral epicondyle. M. extensor carpi radialis brevis was found to consist of a keel-shaped tendon with attachments to m. extensor carpi radialis longus, m. extensor digitorum communis, m. supinator; and to the radial collateral ligament, the orbicular ligament, the capsule of the @entity3 . On 29 limbs, a prolongation of the muscle was identified attaching proximal to the lateral epicondyle. On nine specimens a bursa was evident between the capsule over the head of the radius and the overlying soft tissues. There was no evidence of variation in vascular or nerve supply to the region. Examination of m. extensor carpi radialis brevis while under tension across the elbow, forearm and wrist revealed the greatest muscle lengthening in pronation of the forearm with @entity4 . The results of this study support the hypothesis that @entity2 is primarily a mechanically-induced condition. When performing movements at the wrist, with the forearm in pronation, the muscle is at its maximum length. As its origin lies proximal to the @entity1 for flexion and extension at the elbow, it is subject to shearing stress in all movements of the forearm, especially those involving power at the wrist. This is further compounded by the head of the radius rotating anteriorly against m. extensor carpi radialis brevis during pronation of the forearm. Additionally, a number of individuals may experience @entity0 at the head of the radius during pronation, due to irritation of an underlying bursa.

title: @entity2 . A review of structures associated with XXXX .

answer: @entity2


abstract: Study Design   Retrospective case series. Objective   To determine the effect of @entity1 on the resource utilization and cost in 3270 consecutive @entity0 undergoing elective noninstrumented decompressive surgeries for @entity2 at Mayo Clinic Rochester between 2005 and 2012. Methods   Groups were assessed for baseline differences (age, gender, and American Society of Anesthesiologists [ASA] classification, procedure type, and number of operative levels). Outcome variables included the transfusion requirements during surgery, the total anesthesia and surgical times, intensive care unit (ICU) admissions, standardized costs, as well as the ICU and hospital length of stay (LOS). Regression analysis was used to evaluate for strength of association between @entity1 and outcome variables. Results   Baseline differences between the groups (nonobese: n   =   1,853; @entity1 : n   =   1,417) were found with respect to age, ASA class, gender, procedure type, and number of operative levels. After correcting for differences, we found significant associations between @entity1 and surgical (p   <   0.0001) and anesthesia times (p   <   0.0001) and hospital LOS (p   <   0.0001). Additionally, ICU admission rates (p   =   0.02) and requirement for postoperative ventilation (p   =   0.048) were significantly higher in @entity1 @entity0 . Finally, mean difference in total cost ( 1,632, p   <   0.0001) was significantly higher for the @entity1 cohort. Conclusion   Obesity is associated with increased resource utilization and cost in @entity0 undergoing a noninstrumented decompressive surgery for @entity2 .

title: The Impact of Obesity on Perioperative Resource Utilization after Elective Spine Surgery for XXXX .

answer: @entity2


abstract: INTRODUCTION: An internal abdominal herniation is the protrusion of a viscus through a normal or abnormal mesenteric or peritoneal aperture. It is a rare cause of @entity7 with a reported incidence of 0.2-0.9%. It can either be acquired through a @entity2 or surgical procedure or can be related to @entity9 . Herniation through transverse mesocolon is very rare. PRESENTATION OF CASE: A case of @entity6 due to internal herniation through a congenital rent in transverse mesocolon with rotation of gut approximately 180   around axis of the band. @entity0 also had bilateral hypoplastic thenar muscles with rudimentary 1st metacarpals and high arched feet. Reduction along with derotation of gut, with closure of the rent in transverse mesocolon and fixation of the caecum to lateral peritoneum was performed. DISCUSSION: The preoperative diagnosis of @entity3 is difficult because of wide range of acute abdominal symptoms, and there are no specific radiographic findings. CT is the most important diagnostic tool is, with 77% accuracy in such cases. Due to the risk of strangulation of the hernial contents, even small internal hernias are dangerous and may be lethal. CONCLUSION: Internal @entity5 should be suspected in @entity0 with signs and symptoms of @entity6 , particularly in the absence of inflammatory @entity8 , external @entity5 or previous laparotomy. Surgical decision-making is on the basis of clinical findings of @entity8 or @entity1 , and emergency laparotomy should be performed without preoperative diagnosis of such a @entity4 .

title: An unusual case of transverse mesocolic internal XXXX with abnormality of both hands and high arched feet.

answer: @entity5


abstract: INTRODUCTION: @entity5 is the term given to @entity1 arising from Schwann cells of any nerve @entity7 . It may arise in the retroperitoneum, where it can attain enormous sizes and cause considerable diagnostic and therapeutic difficulties. A variety of incapacitating symptoms may arise, depending on its size alone and the related contagious organs. PRESENTATION OF CASE: A 71-year-old female, who was incapacitated by a giant abdominal mass, associated with @entity2 , immobility, general @entity3 and @entity6 . Radiologically, the presence of a huge @entity1 was confirmed. A preoperative tissue diagnosis was entertained but omitted, and we resorted to direct surgical excision instead. During surgery, significant @entity4 from the surrounding lumbar vessels was encountered, but it was controlled and the @entity1 was excised intact. Histopathologically, it showed the histologic features of @entity5 . DISCUSSION: In the @entity0 presented here, who was rendered immobile by the @entity1 , total excision or at least debulking seemed appropriate, regardless of any biopsy result. CONCLUSION: The diagnosis of @entity5 and its variant " @entity5 " should be considered when a huge @entity1 is encountered. Although CT guided biopsy may be helpful in reaching a preoperative diagnosis, this might not change the decision for the need of total @entity1 excision or at least debulking, in the presence of incapacitating symptoms. With large @entity1 , the possibility of perioperative exanginating @entity4 should be remembered and the necessary precautions activated.

title: XXXX : Is preoperative biopsy always mandatory?

answer: @entity5


abstract: Objective   To report our results and the technical details of fully endoscopic resection of @entity6 . Design   Prospective observational study. Setting   A single academic institution involving neurosurgery and neurotology. @entity0   Twelve consecutive @entity0 who underwent fully endoscopic resection of a @entity6 . Main Outcome Measures   Hearing preservation, based on the American Association of Otolaryngology-Head and Neck Surgeons (AAO-HNS) score as well as the Gardener and Robertson Modified Hearing Classification (GR). Facial nerve preservation based on the House-Brackmann (HB) score. Results   All @entity0 successfully underwent gross total resection. Facial nerve preservation rate was 92% with 11 of 12 @entity0 retaining an HB score of 1/6 postoperatively. Hearing preservation rate was 67% with 8 of 12 @entity0 maintaining a stable AAO-HNS grade and GR score at follow-up. Mean @entity1 size was 1.5 cm (range: 1-2 cm). No @entity0 experienced postoperative @entity5 , @entity4 , or @entity2 for a complication rate of 0%. Mean operative time was 261.6 minutes with an estimated @entity3 of 56.3 mL and average length of hospital stay of 3.6 days. Conclusion   A purely endoscopic approach is a safe and effective option for hearing preservation surgery for @entity6 in appropriately selected @entity0 .

title: Endoscopic Resection of XXXX .

answer: @entity6


abstract: PURPOSE: Deep inspiration breath hold (DIBH) is used to decrease cardiac irradiation during @entity3 ( @entity3 ) for @entity0 . The @entity1 most likely to benefit and the impact on treatment time remain largely unknown. We sought to identify predictors for the use of DIBH and to quantify differences in dosimetry and treatment time using a prospective registry. METHODS AND MATERIALS: A total of 150 @entity1 with @entity0 were enrolled. All @entity1 were simulated with both free breathing (FB) and DIBH. @entity3 was delivered by either modality. Alternate scans were planned with use of deformable registration to include identical @entity3 volumes. DIBH @entity1 were monitored by a real-time surface tracking system, AlignRT (Vision @entity3 , Ltd, London, United Kingdom). Baseline characteristics and treatment times were compared by Fisher exact test and Wilcoxon rank sum test. Dosimetric endpoints were analyzed by Wilcoxon signed rank test, and linear regression identified predictors for change in @entity2 (   @entity2 ). RESULTS: We treated 38 @entity1 with FB and 110 with DIBH. FB @entity1 were older, more likely to have @entity2 , and less likely to receive chemotherapy or immediate reconstruction (all P < .05). Treatment times were not significantly different, but DIBH @entity1 had greater variability in times (P = .0002). Of 146 evaluable @entity1 , DIBH resulted in >20 cGy improvement in @entity2 in 107 @entity1 but a >20 cGy increase in @entity2 in 14. Both @entity2 and lung V20 were significantly lower in DIBH than in paired FB plans. On multivariate analysis, younger age (4.18 cGy per year; P < .0001), higher body mass index (6.06 cGy/kg/m(2); P = .0018), and greater change in lung volumes (130 cGy/L; P = .003) were associated with greater    @entity2 . CONCLUSIONS: DIBH improves cardiac dosimetry without significantly impacting treatment time in most @entity1 . Greater inspiratory lung volumes augment this benefit. Because the improvement with DIBH was not uniform, @entity1 should be scanned with both FB and DIBH.

title: Prospective assessment of deep inspiration breath-hold using 3-dimensional surface tracking for irradiation of left-sided XXXX .

answer: @entity0


abstract: BACKGROUND: Long-chain @entity4 (LCPUFA) are important for prenatal brain development. Previous studies of others assessed outcome until 7years. The associations between neonatal LCPUFA status and long-term developmental outcome are debated. AIM: To investigate the relationship between @entity2 status at birth and neurodevelopment at 9years. Age 9 is a unique age after a significant neurodevelopmental transition. STUDY DESIGN: Correlation study. Multivariable analyses were carried out to adjust for potential confounders. SUBJECTS: 317 @entity0 who participated in a trial on effects of postnatal LCPUFA supplementation were eligible. 235 @entity0 (74%) were reassessed at age 9. OUTCOME MEASURES: At birth, @entity5 ( @entity6 ) and @entity3 (AA) were determined in the wall of the umbilical vein. We primarily studied the correlation between @entity6 and AA with the complex form of minor @entity1 (cMND). Secondary correlations that were studied were @entity6 and AA levels with cognitive development in terms of full IQ, and with behavioural development in terms of a total problem score. RESULTS: @entity0 with cMND showed lower @entity6 values in the umbilical vein than @entity0 with better neurological condition (p=0.033). A similar association was absent in @entity0 . Neonatal AA values were not associated with neurological outcome. Neither neonatal @entity6 nor AA values were associated with cognition and behaviour at 9. CONCLUSIONS: Higher umbilical @entity6 levels in @entity0 are associated with better neurological development at 9years. AA status at birth was not associated with neurodevelopment at 9years.

title: Neonatal XXXX status and neurodevelopmental outcome at 9years.

answer: @entity2


abstract: BACKGROUND: Considering the proximity to cranial nerves from II to VI and the internal carotid artery microsurgery for @entity4 ( @entity4 ) has its limits of complete resection, with high potential @entity1 recurrences, cranial nerve and vascular morbidity. Gamma Knife surgery (GKS) is an advanced modality as primary treatment for @entity0 harboring symptomatic benign confined @entity4 as well as adjuvant therapy to postoperative @entity2 giving a high rate of @entity1 control, stabilizing or even improving clinical condition with low morbidity. MATERIALS AND METHODS: The aim of this study is to evaluate the safety and efficacy of GKS used in the management of 62 @entity0 with symptomatic benign confined @entity4   <   3  cm in maximum diameters treated at the International Medical Centre (IMC), Cairo, Egypt, from 2005 to end of 2012, with mean follow-up period of 36  months (range, 24-96  months) by reviewing their clinical and radiological data. For 51 @entity0 GKS was performed as a primary treatment. The diagnosis was based on typical clinical and imaging findings and in 11 @entity0 GKS was used as adjuvant to post-operative @entity1 residual with histological confirmation. RESULTS: There were 43 females and 19 males. The median age at the time of treatment was 48  years. The mean @entity1 volume was 5.7  cc, the mean @entity1 marginal radiation dose was 14.4  Gy, the mean isodose line was 38  %, and the mean @entity1 coverage was 94.4  %. The optic pathway received    <   8  Gy and the brain stem    <   10  Gy. At most recent follow-up, 57 @entity0 (92  %) had stable or improved @entity3 . @entity3 were detected in five @entity0 (8  %). @entity1 volume was controlled in 60 @entity0 (96  %) at most recent follow-up MRI; 12 @entity0 had a reduction in @entity1 size and 42 had stable @entity1 size, while @entity1 size progression was detected in two @entity0 . The @entity1 progression-free survival at 3 and 5  years in 40 @entity0 who completed at least 5  years of follow-up was 95  %. CONCLUSIONS: Gamma Knife surgery is a safe and effective option for the treatment of @entity4 not only as an adjuvant to surgery but also as an alternative to surgical @entity1 confined mainly to the cavernous sinus.

title: Stereotactic Gamma Knife surgery safety and efficacy in the management of symptomatic benign confined XXXX .

answer: @entity4


abstract: OBJECTIVE: @entity0 @entity12 ( @entity12 ), a @entity5 protease, plays an important role in the regulation of cell proliferation and @entity1 growth. In this work, we investigated @entity12 immunoexpression in various types of surgically removed @entity0 @entity7 . DESIGN: Specimens were fixed in @entity4 and embedded in paraffin. Immunostaining was performed by the streptavidin- @entity9 -peroxidase complex protocol using the LSAB+ Kit and a @entity12 -specific rabbit polyclonal antibody. RESULTS: Results showed that both treated and untreated prolactin-producing @entity7 as well as TSH-producing @entity7 were conclusively immunopositive for @entity12 . Immunostaining was mainly localized in the cytoplasm and was clearly visible in many @entity6 cells. In various other @entity1 types ( @entity8 , gonadotroph, somatotroph @entity6 , and @entity3 ), cytoplasmic immunopositivity was mild to moderate and seen only in a few unevenly distributed @entity6 cells. Immunopositivity in the nuclei of various @entity1 types, as well as dual cytoplasmic and nuclear localization of @entity12 in some of the @entity1 types, was an intriguing finding. Immunoexpression in GH-producing @entity6 exposed to @entity11 , a long-acting @entity10 analog, was significantly increased when compared to unexposed GH-producing @entity1 . CONCLUSION: More studies are needed to ascertain the role of @entity12 in @entity7 development, prognosis, and progression. The question of whether @entity2 and the microenvironment can affect @entity12 immunoexpression should also be investigated.

title: @entity0 kallikrein 10 in surgically removed @entity0 XXXX .

answer: @entity7


abstract: OBJECTIVE: @entity0 @entity12 ( @entity12 ), a @entity5 protease, plays an important role in the regulation of cell proliferation and @entity1 growth. In this work, we investigated @entity12 immunoexpression in various types of surgically removed @entity0 @entity7 . DESIGN: Specimens were fixed in @entity4 and embedded in paraffin. Immunostaining was performed by the streptavidin- @entity9 -peroxidase complex protocol using the LSAB+ Kit and a @entity12 -specific rabbit polyclonal antibody. RESULTS: Results showed that both treated and untreated prolactin-producing @entity7 as well as TSH-producing @entity7 were conclusively immunopositive for @entity12 . Immunostaining was mainly localized in the cytoplasm and was clearly visible in many @entity6 cells. In various other @entity1 types ( @entity8 , gonadotroph, somatotroph @entity6 , and @entity3 ), cytoplasmic immunopositivity was mild to moderate and seen only in a few unevenly distributed @entity6 cells. Immunopositivity in the nuclei of various @entity1 types, as well as dual cytoplasmic and nuclear localization of @entity12 in some of the @entity1 types, was an intriguing finding. Immunoexpression in GH-producing @entity6 exposed to @entity11 , a long-acting @entity10 analog, was significantly increased when compared to unexposed GH-producing @entity1 . CONCLUSION: More studies are needed to ascertain the role of @entity12 in @entity7 development, prognosis, and progression. The question of whether @entity2 and the microenvironment can affect @entity12 immunoexpression should also be investigated.

title: XXXX kallikrein 10 in surgically removed @entity0 @entity7 .

answer: @entity0


abstract: OBJECTIVE: @entity0 @entity12 ( @entity12 ), a @entity5 protease, plays an important role in the regulation of cell proliferation and @entity1 growth. In this work, we investigated @entity12 immunoexpression in various types of surgically removed @entity0 @entity7 . DESIGN: Specimens were fixed in @entity4 and embedded in paraffin. Immunostaining was performed by the streptavidin- @entity9 -peroxidase complex protocol using the LSAB+ Kit and a @entity12 -specific rabbit polyclonal antibody. RESULTS: Results showed that both treated and untreated prolactin-producing @entity7 as well as TSH-producing @entity7 were conclusively immunopositive for @entity12 . Immunostaining was mainly localized in the cytoplasm and was clearly visible in many @entity6 cells. In various other @entity1 types ( @entity8 , gonadotroph, somatotroph @entity6 , and @entity3 ), cytoplasmic immunopositivity was mild to moderate and seen only in a few unevenly distributed @entity6 cells. Immunopositivity in the nuclei of various @entity1 types, as well as dual cytoplasmic and nuclear localization of @entity12 in some of the @entity1 types, was an intriguing finding. Immunoexpression in GH-producing @entity6 exposed to @entity11 , a long-acting @entity10 analog, was significantly increased when compared to unexposed GH-producing @entity1 . CONCLUSION: More studies are needed to ascertain the role of @entity12 in @entity7 development, prognosis, and progression. The question of whether @entity2 and the microenvironment can affect @entity12 immunoexpression should also be investigated.

title: @entity0 kallikrein 10 in surgically removed XXXX @entity7 .

answer: @entity0


abstract: OBJECTIVE: To study @entity5 ( @entity5 ) in @entity0 suffering from @entity9 and compare these results with age and BMI-matched healthy @entity0 . The specific aim of this study was to assess the possible correlations of @entity5 with the major components of @entity9 , @entity1 , @entity7 resistance and @entity8 . DESIGN: Anthropometrical, metabolic and hormonal data were analyzed from 203 @entity0 with @entity9 (NIH criteria) and 76 age-matched controls. RESULTS: In the total population studied (N=279), @entity5 was significantly higher (P=0.003) in the @entity9 group compared with age-matched healthy @entity0 and was positively correlated with BMI (r=0.461, p<0.001), total @entity3 (r= 0.210, p<0.001), @entity7 (r=0.271, p<0.001), @entity6 (r=0.285, p<0.001), HOMA score (r=0.206, p=0.001), FAI (r=0.329, p<0.001) and negatively correlated with @entity4 (r=-0.300, p<0.001) and HDL (r=-0.222, p<0.001). Due to the fact that WHR was only available in the group of @entity9 @entity0 , the role of central adiposity is assessed only in this group. Multiple regression analysis in the @entity9 group, including WHR, revealed BMI, @entity4 and TGL as the main predicting factors of @entity5 . Multinomial logistic regression analysis was also conducted and overweight/ @entity1 was the sole independent risk factor for elevated @entity5 (higher tertile) (OR:0.907 CI:0.85-0.96, p=0.002). After dividing the sample based on BMI in the lean subgroups, @entity5 did not differ significantly between @entity9 and controls, while multiple regression analysis indicated @entity4 as the main predicting factor of @entity5 . Finally, we picked out the group of overweight/ @entity1 (BMI >= 25 kg/m2) @entity0 with @entity9 and conducted another classification based on HOMA score (HOMA-IR <=2: @entity7 -sensitive @entity0 , HOMA-IR>2: @entity7 -resistant @entity0 ) in the group of overweight and @entity1 @entity0 with @entity9 separately. In overweight @entity0 with @entity9 , @entity5 , although higher in the group of @entity7 -resistant, did not differ significantly between the two groups, while in the subcategory of overweight @entity0 @entity5 was significantly (p=0.02) higher in the group of @entity7 -resistant @entity0 (HOMA-IR >2). CONCLUSIONS: Chronic low-grade @entity2 and increased white cell count do occur in @entity9 . @entity1 and @entity7 resistance are the two leading parameters that act accumulatively in the development of leucocytosis, whereas @entity8 does not seem to affect it.

title: White blood cells levels and XXXX : direct and indirect relationship with @entity1 and @entity7 resistance, but not with hyperandogenemia.

answer: @entity9


abstract: OBJECTIVE: To study @entity5 ( @entity5 ) in @entity0 suffering from @entity9 and compare these results with age and BMI-matched healthy @entity0 . The specific aim of this study was to assess the possible correlations of @entity5 with the major components of @entity9 , @entity1 , @entity7 resistance and @entity8 . DESIGN: Anthropometrical, metabolic and hormonal data were analyzed from 203 @entity0 with @entity9 (NIH criteria) and 76 age-matched controls. RESULTS: In the total population studied (N=279), @entity5 was significantly higher (P=0.003) in the @entity9 group compared with age-matched healthy @entity0 and was positively correlated with BMI (r=0.461, p<0.001), total @entity3 (r= 0.210, p<0.001), @entity7 (r=0.271, p<0.001), @entity6 (r=0.285, p<0.001), HOMA score (r=0.206, p=0.001), FAI (r=0.329, p<0.001) and negatively correlated with @entity4 (r=-0.300, p<0.001) and HDL (r=-0.222, p<0.001). Due to the fact that WHR was only available in the group of @entity9 @entity0 , the role of central adiposity is assessed only in this group. Multiple regression analysis in the @entity9 group, including WHR, revealed BMI, @entity4 and TGL as the main predicting factors of @entity5 . Multinomial logistic regression analysis was also conducted and overweight/ @entity1 was the sole independent risk factor for elevated @entity5 (higher tertile) (OR:0.907 CI:0.85-0.96, p=0.002). After dividing the sample based on BMI in the lean subgroups, @entity5 did not differ significantly between @entity9 and controls, while multiple regression analysis indicated @entity4 as the main predicting factor of @entity5 . Finally, we picked out the group of overweight/ @entity1 (BMI >= 25 kg/m2) @entity0 with @entity9 and conducted another classification based on HOMA score (HOMA-IR <=2: @entity7 -sensitive @entity0 , HOMA-IR>2: @entity7 -resistant @entity0 ) in the group of overweight and @entity1 @entity0 with @entity9 separately. In overweight @entity0 with @entity9 , @entity5 , although higher in the group of @entity7 -resistant, did not differ significantly between the two groups, while in the subcategory of overweight @entity0 @entity5 was significantly (p=0.02) higher in the group of @entity7 -resistant @entity0 (HOMA-IR >2). CONCLUSIONS: Chronic low-grade @entity2 and increased white cell count do occur in @entity9 . @entity1 and @entity7 resistance are the two leading parameters that act accumulatively in the development of leucocytosis, whereas @entity8 does not seem to affect it.

title: White blood cells levels and @entity9 : direct and indirect relationship with XXXX and @entity7 resistance, but not with hyperandogenemia.

answer: @entity1


abstract: OBJECTIVE: To study @entity5 ( @entity5 ) in @entity0 suffering from @entity9 and compare these results with age and BMI-matched healthy @entity0 . The specific aim of this study was to assess the possible correlations of @entity5 with the major components of @entity9 , @entity1 , @entity7 resistance and @entity8 . DESIGN: Anthropometrical, metabolic and hormonal data were analyzed from 203 @entity0 with @entity9 (NIH criteria) and 76 age-matched controls. RESULTS: In the total population studied (N=279), @entity5 was significantly higher (P=0.003) in the @entity9 group compared with age-matched healthy @entity0 and was positively correlated with BMI (r=0.461, p<0.001), total @entity3 (r= 0.210, p<0.001), @entity7 (r=0.271, p<0.001), @entity6 (r=0.285, p<0.001), HOMA score (r=0.206, p=0.001), FAI (r=0.329, p<0.001) and negatively correlated with @entity4 (r=-0.300, p<0.001) and HDL (r=-0.222, p<0.001). Due to the fact that WHR was only available in the group of @entity9 @entity0 , the role of central adiposity is assessed only in this group. Multiple regression analysis in the @entity9 group, including WHR, revealed BMI, @entity4 and TGL as the main predicting factors of @entity5 . Multinomial logistic regression analysis was also conducted and overweight/ @entity1 was the sole independent risk factor for elevated @entity5 (higher tertile) (OR:0.907 CI:0.85-0.96, p=0.002). After dividing the sample based on BMI in the lean subgroups, @entity5 did not differ significantly between @entity9 and controls, while multiple regression analysis indicated @entity4 as the main predicting factor of @entity5 . Finally, we picked out the group of overweight/ @entity1 (BMI >= 25 kg/m2) @entity0 with @entity9 and conducted another classification based on HOMA score (HOMA-IR <=2: @entity7 -sensitive @entity0 , HOMA-IR>2: @entity7 -resistant @entity0 ) in the group of overweight and @entity1 @entity0 with @entity9 separately. In overweight @entity0 with @entity9 , @entity5 , although higher in the group of @entity7 -resistant, did not differ significantly between the two groups, while in the subcategory of overweight @entity0 @entity5 was significantly (p=0.02) higher in the group of @entity7 -resistant @entity0 (HOMA-IR >2). CONCLUSIONS: Chronic low-grade @entity2 and increased white cell count do occur in @entity9 . @entity1 and @entity7 resistance are the two leading parameters that act accumulatively in the development of leucocytosis, whereas @entity8 does not seem to affect it.

title: White blood cells levels and @entity9 : direct and indirect relationship with @entity1 and XXXX resistance, but not with hyperandogenemia.

answer: @entity7


abstract: Purpose. To study radiological response to stereotactic radiotherapy for focal @entity2 . Materials and Methods. In this IRB-approved, HIPAA-compliant study CTs of 68 consecutive @entity0 who underwent stereotactic radiotherapy for @entity2 between 01/2006 and 01/2010 were retrospectively reviewed. Two independent reviewers evaluated lesion volume and enhancement pattern of the lesion and of juxtaposed liver parenchyma. Results. 36 subjects with @entity3 ( @entity3 ), 25 with liver @entity1 , and seven with @entity4 ( @entity4 ) were included in study. Mean follow-up time was 5.6    7.1 months for @entity3 , 6.4    5.1 months for @entity1 , and 10.1    4.8 months for the @entity4 . Complete response was seen in 4/36 (11.1%) HCCs and 1/25 (4%) @entity1 . Partial response (>30% decrease in long diameter) was seen in 25/36 (69%) HCCs, 14/25 (58%) @entity1 , and 7/7 (100%) of CCCs. Partial response followed by local recurrence (>20% increase in long diameter from nadir) occurred in 2/36 (6%) HCCs and 4/25 (17%) @entity1 . Liver parenchyma adjacent to the lesion demonstrated a prominent halo of delayed enhancement in 27/36 (78%) of HCCs, 19/21 (91%) of @entity1 , and 7/7 (100%) of CCCs. Conclusion. Sustainable radiological partial response to stereotactic radiotherapy is most frequent outcome seen in @entity5 . Prominent halo of delayed enhancement of the adjacent liver is frequent finding.

title: CT Imaging Findings after Stereotactic Radiotherapy for XXXX .

answer: @entity2


abstract: BACKGROUND: It remains unknown whether sequestrectomy provides better outcomes than microdiscectomy for @entity3 ( @entity3 ). Therefore, we conducted a meta-analysis to compare the effects of sequestrectomy and microdiscectomy in the treatment of @entity0 with @entity3 . METHODS: Clinical trials published in PubMed, Embase, and Web of Science were systematically reviewed to compare the effects of sequestrectomy and microdiscectomy for @entity3 . Outcomes included reherniation rate, duration of surgery, length of hospital stay, and postoperative Visual Analog Scale (VAS) scales for @entity2 . A fixed-effects or random-effects were used to pool the estimates, depending on the heterogeneity among the studies. RESULTS: Five cohorts and two randomized controlled trials (RCTs) with a total of 929 @entity0 met the inclusion criteria and were included in this meta-analysis. All @entity0 underwent sequestrectomy or microdiscectomy. Pooled estimates showed that @entity0 treated with sequestrectomy had comparable effects in reherniation rate (RR = 1.36, 95% CI: 0.81, 2.27; P = 0.240), length of hospital stay (WMD = -0.22 days, 95% CI: -0.45, 0.01; P = 0.060), and postoperative VAS scales for leg @entity1 (WMD = 0.53, 95% CI: -1.54, 2.60; P = 0.617) or back @entity1 (WMD = 0.18, 95% CI: -1.64, 2.00; P = 0.846), but had a shorter duration of surgery (WMD = -6.97 minutes, 95% CI: -12.15, -1.78; P = 0.008), when compared with those treated with microdiscectomy. CONCLUSION: Based on the current evidence, sequestrectomy significantly reduced the operational time, but had similar effects on reherniation rate, length of hospital stay, and postoperative VAS scales for @entity2 , when compared with microdiscectomy. Further well-designed randomized controlled studies are needed to identify our findings.

title: Sequestrectomy versus microdiscectomy in the treatment of XXXX : a meta-analysis.

answer: @entity3


abstract: AIM: To evaluate the surgical outcomes of 47 @entity0 who underwent hemorrhoidal arterial ligation under vision (LUV) for symptomatic Grade II and @entity5 . METHODS: A total of 47 @entity0 who underwent LUV between May 2005 and February 2009 were analyzed retrospectively. The @entity0 were evaluated with regard to demographic data, grade of the disease, symptoms, medical and/or surgical treatment previously received, operation time, @entity1 scores, analgesic requirement, length of hospital stay, and complications related to the procedure. RESULTS: The study population (n  =  47) included 31 (65.9%) @entity0 and 16 (34.1%) @entity0 with a median age of 37.4      11.7 (range, 19-63) years. Of these 47 @entity0 , 18 (38.3%) @entity0 had Grade II @entity5 ( @entity5 ) and 29 (61.7%) @entity0 had @entity5 . On average, six ligatures (range, 3-8) were used. The mean operation time was 27      4.8 (range, 15-35) minutes. No major complication that required surgical intervention occurred in the early postoperative period for any of the @entity0 except for two @entity0 with @entity4 . The mean hospital stay was 1.2      0.65 (range, 1-4) days. The median follow-up period was 21.5      7.7 (range, 12-44) months. At the last follow-up, 38 (80.8%) @entity0 remained asymptomatic; two (4.2%) @entity0 with Grade II @entity5 and four (8.5%) @entity0 with @entity5 were still suffering from @entity3 but with a reduction in the frequency; @entity5 were detected only in three (6.3%) @entity0 . CONCLUSION: LUV is a safe and easily applied alternative technique with @entity2 for the surgical treatment of symptomatic @entity5 .

title: Ligation under vision in the management of symptomatic XXXX : A preliminary experience.

answer: @entity5


abstract: OBJECTIVE: We evaluated pregnancy outcomes, maternal and fetal/neonatal, during the Treatment Options for type 2 @entity1 in Adolescents and Youth (TODAY) study. RESEARCH DESIGN AND METHODS: The TODAY study was a randomized controlled trial comparing three treatment options for youth with type 2 @entity1 . Informed consent included the requirement for contraception, including abstinence; this was reinforced at each visit. Following informed consent, self-reported data related to the mother's prenatal care and delivery and the @entity0 's health were retrospectively collected. When permitted, maternal medical records and @entity0 birth records were reviewed. RESULTS: Of the 452 enrolled female @entity0 , 46 (10.2%) had 63 pregnancies. Despite continued emphasis on adequate contraception, only 4.8% of the pregnant @entity0 reported using contraception prior to pregnancy. The mean age at first pregnancy was 18.4 years; the mean @entity1 duration was 3.17 years. Seven pregnancies were electively terminated; three pregnancies had no data reported. Of the remaining 53 pregnancies, 5 (9.4%) resulted in early @entity4 , and 7 (13%) resulted in loss with inadequate pregnancy duration data. Two pregnancies ended in stillbirth, at 27 and 37 weeks, and 39 ended with a live-born @entity0 . Of the live-born @entity0 , six (15.4%) were preterm and eight (20.5%) had a major @entity3 . CONCLUSIONS: Despite @entity1 -specific information recommending birth control and the avoidance of pregnancy, 10% of the study @entity0 became pregnant. Pregnancies in youth with type 2 @entity1 may be especially prone to result in @entity3 . Reasons for the high rate of @entity3 are uncertain, but may include poor metabolic control and extreme @entity2 .

title: Pregnancy Outcomes in Youth With Type 2 XXXX : The TODAY Study Experience.

answer: @entity1


abstract: BACKGROUND: Concern for @entity3 causing airway compromise has limited widespread acceptance of ambulatory thyroid surgery. We evaluated differences in outcomes and hospital costs in those monitored for a short stay of 6  h (SS), inpatient observation of 6-23  h (IO), or inpatient admission of >23  h (IA). METHODS: We retrospectively reviewed all @entity0 undergoing thyroidectomy from 2006 to 2012. The incidence of @entity1 , @entity2 , and @entity7 were evaluated, as well as cost data comparing the SS and IO groups. RESULTS: Of 1447 thyroidectomies, 880 (60.8  %) were performed as SS, 401 (27.7  %) as IO, and 166 (11.5  %) as IA. Fewer @entity0 in the SS group (59  %) underwent total thyroidectomy than IO (73  %) and IA (71  %; p  <  0.01), and SS @entity0 had smaller thyroid weights (27.9  g) compared with IO and IA (47.2 and 98.9  g, respectively; p  <  0.01). Ten (0.69  %) @entity0 developed @entity6 requiring reoperation, five of the ten patients received antiplatelet or anticoagulant therapy perioperatively. Only one @entity0 in the IA group bled within the 6- to 23-h period, and no @entity0 with @entity5 who were discharged at 6  h would have benefitted from 23-h observation. Twenty-four (1.66  %) recurrent @entity8 were identified, 16 with @entity4 . In addition, 24 (1.66  %) @entity0 had symptomatic @entity7 , which was transient in 17 individuals. Financial data showed higher payments and lower costs associated with SS compared with IO. CONCLUSIONS: Selective SS thyroidectomy can be safe and cost effective, with few overall complications in @entity0 undergoing more complex operations involving larger thyroids who were admitted to hospital.

title: An XXXX and Cost After Short-Stay Thyroid Operations.

answer: @entity3


abstract: One hundred ninety-six head and neck @entity0 were studied to determine the effects of radiation therapy and surgery on thyroid function. Serum thyroid-stimulating hormone (TSH) levels were obtained as a screening test for @entity2 . Elevated TSH levels were found in 57 of the 196 @entity0 (29.1%). The highest incidence of abnormal TSH values (66%) occurred in the group treated with combination radiation therapy and surgery, including partial thyroidectomy. TSH levels rose early in the posttreatment period with 60% of the abnormal values occurring within the first three posttreatment years. Posttreatment @entity1 was twice as common in @entity0 (48.6%) as in @entity0 (25.4%). When serum @entity3 levels by radioimmunoassay (T4RIA) were correlated with the elevated serum TSH levels, a similar pattern was seen with 65% of the @entity0 in Group 3 having a decreased T4RIA level indicating @entity2 . Pretreatment levels of thyroid function including thyroid antibody studies should be established for all @entity0 . Serial TSH levels should be done every three months during the first three posttreatment years and semiannually thereafter as long as the @entity0 will return for follow-up care. All @entity0 treated with combination radiation therapy and surgery who develop elevated TSH levels should be treated with thyroid replacement therapy. @entity0 receiving radiation therapy alone should receive replacement thyroid therapy if they develop a depressed T4RIA value or a pattern of gradually increasing TSH levels.

title: XXXX following treatment for head and neck cancer.

answer: @entity2


abstract: INTRODUCTION: There are very few surveys devoted to the prevalence of @entity1 and @entity2 in the general population. The Motorola Health System has been developed to make such surveys easier. OBJECTIVES: The main objective was to assess the acceptability and efficacy of the Motorola Health system in collecting health data at home in the context of an epidemiological study of respiratory health. The secondary objective was to determine whether a home-based survey would lead to a higher participation rate than a hospital-based survey. METHODS: Four hundred and eighty-three individuals were selected from the electoral rolls of the 15th district of Marseille and randomly divided into two groups: home-based and hospital-based. The protocol included a questionnaire, several measurements: height, weight, blood pressure, spirometry and pulse oxymetry, and blood sampling. All data were transferred to a portable computer. RESULTS: Data acquisition and transfer worked well. Among the 232  subjects from the home-based survey, 62 (26.7%) participated, whereas only 36 (14.3%) of the 251  subjects from the hospital-based group did so (P<0.001). In an additional telephone survey, @entity0 (13.6%) and non- @entity0 (11.0%) had the same (P<0.9) prevalence of @entity1 . CONCLUSION: The Motorola Health System allowed accurate data acquisition and transfer in the context of an epidemiological survey of respiratory health. A home-based survey gave a higher participation rate than a hospital-based one.

title: [The feasibility of screening for XXXX and @entity1 in the general population].

answer: @entity2


abstract: INTRODUCTION: There are very few surveys devoted to the prevalence of @entity1 and @entity2 in the general population. The Motorola Health System has been developed to make such surveys easier. OBJECTIVES: The main objective was to assess the acceptability and efficacy of the Motorola Health system in collecting health data at home in the context of an epidemiological study of respiratory health. The secondary objective was to determine whether a home-based survey would lead to a higher participation rate than a hospital-based survey. METHODS: Four hundred and eighty-three individuals were selected from the electoral rolls of the 15th district of Marseille and randomly divided into two groups: home-based and hospital-based. The protocol included a questionnaire, several measurements: height, weight, blood pressure, spirometry and pulse oxymetry, and blood sampling. All data were transferred to a portable computer. RESULTS: Data acquisition and transfer worked well. Among the 232  subjects from the home-based survey, 62 (26.7%) participated, whereas only 36 (14.3%) of the 251  subjects from the hospital-based group did so (P<0.001). In an additional telephone survey, @entity0 (13.6%) and non- @entity0 (11.0%) had the same (P<0.9) prevalence of @entity1 . CONCLUSION: The Motorola Health System allowed accurate data acquisition and transfer in the context of an epidemiological survey of respiratory health. A home-based survey gave a higher participation rate than a hospital-based one.

title: [The feasibility of screening for @entity2 and XXXX in the general population].

answer: @entity1


abstract: INTRODUCTION: @entity2 is the most advanced stage of @entity1 for which radical (potentially curative) treatment is often discussed. Understanding the reasons for mortality and subsequent treatments in @entity0 with stage iii @entity5 ( @entity5 ) is important. METHODS: This retrospective cohort study extracted demographic, clinical, treatment, and outcomes data for @entity0 with newly diagnosed stage iii @entity5 diagnosed between 1 January 2008 and 31 December 2012 at a single institution. RESULTS: The study included 237 @entity0 with stage iii @entity5 , 130 of whom were not treated with radical or curative intent (55%). Median survival in the entire cohort was 14 months from diagnosis. For @entity0 treated with radical-intent therapy, causes of @entity4 varied with the time period. The hazard rate for @entity4 was approximately 2.8 per 100 @entity0 -months of follow-up over the entire disease course and was highest between 6 months and 24 months. Over the entire time period, local causes accounted for 29% of @entity4 ; systemic @entity6 , for 25%; and brain metastases, for 14%. For @entity0 treated with palliative intent, the overwhelming cause of @entity4 was @entity3 or progression (56% of @entity4 ). Only 12% of @entity0 in the palliative treatment group who progressed received subsequent chemotherapy; 23% of @entity0 in the radical group who progressed received palliative chemotherapy. The most frequent subsequent treatment in both groups was radiation therapy. CONCLUSIONS: The eventual life-ending event in stage iii @entity5 varied for the @entity0 who qualified for, and were treated with, radical or curative intent and for the @entity0 who received palliative-intent therapy. Utilization of systemic chemotherapy in @entity0 not fit for radical therapy is low.

title: Causes of XXXX and subsequent treatment after initial radical or palliative therapy of stage III @entity5 .

answer: @entity4


abstract: INTRODUCTION: @entity2 is the most advanced stage of @entity1 for which radical (potentially curative) treatment is often discussed. Understanding the reasons for mortality and subsequent treatments in @entity0 with stage iii @entity5 ( @entity5 ) is important. METHODS: This retrospective cohort study extracted demographic, clinical, treatment, and outcomes data for @entity0 with newly diagnosed stage iii @entity5 diagnosed between 1 January 2008 and 31 December 2012 at a single institution. RESULTS: The study included 237 @entity0 with stage iii @entity5 , 130 of whom were not treated with radical or curative intent (55%). Median survival in the entire cohort was 14 months from diagnosis. For @entity0 treated with radical-intent therapy, causes of @entity4 varied with the time period. The hazard rate for @entity4 was approximately 2.8 per 100 @entity0 -months of follow-up over the entire disease course and was highest between 6 months and 24 months. Over the entire time period, local causes accounted for 29% of @entity4 ; systemic @entity6 , for 25%; and brain metastases, for 14%. For @entity0 treated with palliative intent, the overwhelming cause of @entity4 was @entity3 or progression (56% of @entity4 ). Only 12% of @entity0 in the palliative treatment group who progressed received subsequent chemotherapy; 23% of @entity0 in the radical group who progressed received palliative chemotherapy. The most frequent subsequent treatment in both groups was radiation therapy. CONCLUSIONS: The eventual life-ending event in stage iii @entity5 varied for the @entity0 who qualified for, and were treated with, radical or curative intent and for the @entity0 who received palliative-intent therapy. Utilization of systemic chemotherapy in @entity0 not fit for radical therapy is low.

title: Causes of @entity4 and subsequent treatment after initial radical or palliative therapy of stage III XXXX .

answer: @entity5


abstract: The presence of a family history of @entity3 is a known risk factor for @entity2 ( @entity2 ) in middle-aged and older individuals. In this study, our aim was to demonstrate possible early @entity5 in young first- and second-degree relatives of @entity2 @entity0 by spectral-domain optical coherence tomography. A total of 104 @entity0 (52 relatives of @entity2 @entity0 and 52 healthy individuals) were recruited in this cross-sectional study. All the @entity0 were between 17 years and 45 years of age. All eyes underwent testing with spectral-domain optical coherence tomography. Peripapillary retinal nerve fiber layer thickness, hemifield macular thickness, @entity4 cell complex thickness, posterior pole asymmetry analysis, and retinal arteriolar caliber measurements were taken for comparison between the study and control groups. The mean peripapillary retinal nerve fiber layer thickness was 104.9    8.8  m in the study group and 105.6    7.4  m in the control group (p = 0.68). Although whole macular thickness measurements were higher in the control group when compared with the study group (p = 0.008), the @entity4 cell complex thickness was similar in both groups (p = 0.87). The posterior pole asymmetry analysis revealed no statistically significant difference between the groups in the aspect of consecutive black squares (p = 0.79). The mean retinal arteriolar caliber was 85.9    4.8  m in the study group and 86.0    5.0  m in the control group (p = 0.90). In conclusion, young relatives of @entity2 @entity0 do not show characteristic @entity1 when compared with the controls.

title: Posterior pole asymmetry analysis and retinal thickness measurements in young relatives of XXXX @entity0 .

answer: @entity3


abstract: The presence of a family history of @entity3 is a known risk factor for @entity2 ( @entity2 ) in middle-aged and older individuals. In this study, our aim was to demonstrate possible early @entity5 in young first- and second-degree relatives of @entity2 @entity0 by spectral-domain optical coherence tomography. A total of 104 @entity0 (52 relatives of @entity2 @entity0 and 52 healthy individuals) were recruited in this cross-sectional study. All the @entity0 were between 17 years and 45 years of age. All eyes underwent testing with spectral-domain optical coherence tomography. Peripapillary retinal nerve fiber layer thickness, hemifield macular thickness, @entity4 cell complex thickness, posterior pole asymmetry analysis, and retinal arteriolar caliber measurements were taken for comparison between the study and control groups. The mean peripapillary retinal nerve fiber layer thickness was 104.9    8.8  m in the study group and 105.6    7.4  m in the control group (p = 0.68). Although whole macular thickness measurements were higher in the control group when compared with the study group (p = 0.008), the @entity4 cell complex thickness was similar in both groups (p = 0.87). The posterior pole asymmetry analysis revealed no statistically significant difference between the groups in the aspect of consecutive black squares (p = 0.79). The mean retinal arteriolar caliber was 85.9    4.8  m in the study group and 86.0    5.0  m in the control group (p = 0.90). In conclusion, young relatives of @entity2 @entity0 do not show characteristic @entity1 when compared with the controls.

title: Posterior pole asymmetry analysis and retinal thickness measurements in young relatives of @entity3 XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity8 , an @entity15 type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown @entity11 following local administration of @entity8 raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of @entity8 are of high value in operative settings and in @entity2 management. The present study aims to investigate if @entity12 ( @entity13 ) could inhibit or prevent @entity8 @entity1 in @entity3 cells (N2a and SH-SY5Y). The viability of N2a and SH-SY5Y cells following exposure to @entity13 (10-50   M) were assessed by @entity0 assay and @entity14 /PI staining. The influence of @entity13 on ROS generation was determined. The expression of apoptotic cascade proteins ( @entity18 , @entity10 , @entity9 , @entity6 , @entity5 ) and @entity4 ( @entity4 , p- @entity4 , @entity16 , p- @entity16 , @entity7 ) were analyzed by western blotting. @entity13 improved the viability of the cells and inhibited apoptosis by potentially decreasing the expression of caspases and pro-apoptotic proteins. @entity8 induced ROS generations were reduced on @entity13 exposure. @entity13 significantly promoted the phosphorylation of @entity4 and @entity16 and down-regulated @entity7 , thus activating @entity17 / @entity4 signalling. @entity13 effectively improved the cell viability and inhibited apoptosis of N2a and SH-SY5Y cells via suppression of ROS generation and modulation of PI3K/ @entity4 signalling cascade.

title: Neuroprotection by @entity12 against @entity8 anesthesia induced @entity1 involves modulation of @entity17 / @entity4 / XXXX signalling in N2a and SH-SY5Y cells.

answer: @entity7


abstract: UNASSIGNED: @entity8 , an @entity15 type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown @entity11 following local administration of @entity8 raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of @entity8 are of high value in operative settings and in @entity2 management. The present study aims to investigate if @entity12 ( @entity13 ) could inhibit or prevent @entity8 @entity1 in @entity3 cells (N2a and SH-SY5Y). The viability of N2a and SH-SY5Y cells following exposure to @entity13 (10-50   M) were assessed by @entity0 assay and @entity14 /PI staining. The influence of @entity13 on ROS generation was determined. The expression of apoptotic cascade proteins ( @entity18 , @entity10 , @entity9 , @entity6 , @entity5 ) and @entity4 ( @entity4 , p- @entity4 , @entity16 , p- @entity16 , @entity7 ) were analyzed by western blotting. @entity13 improved the viability of the cells and inhibited apoptosis by potentially decreasing the expression of caspases and pro-apoptotic proteins. @entity8 induced ROS generations were reduced on @entity13 exposure. @entity13 significantly promoted the phosphorylation of @entity4 and @entity16 and down-regulated @entity7 , thus activating @entity17 / @entity4 signalling. @entity13 effectively improved the cell viability and inhibited apoptosis of N2a and SH-SY5Y cells via suppression of ROS generation and modulation of PI3K/ @entity4 signalling cascade.

title: Neuroprotection by @entity12 against @entity8 anesthesia induced XXXX involves modulation of @entity17 / @entity4 / @entity7 signalling in N2a and SH-SY5Y cells.

answer: @entity1


abstract: UNASSIGNED: @entity8 , an @entity15 type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown @entity11 following local administration of @entity8 raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of @entity8 are of high value in operative settings and in @entity2 management. The present study aims to investigate if @entity12 ( @entity13 ) could inhibit or prevent @entity8 @entity1 in @entity3 cells (N2a and SH-SY5Y). The viability of N2a and SH-SY5Y cells following exposure to @entity13 (10-50   M) were assessed by @entity0 assay and @entity14 /PI staining. The influence of @entity13 on ROS generation was determined. The expression of apoptotic cascade proteins ( @entity18 , @entity10 , @entity9 , @entity6 , @entity5 ) and @entity4 ( @entity4 , p- @entity4 , @entity16 , p- @entity16 , @entity7 ) were analyzed by western blotting. @entity13 improved the viability of the cells and inhibited apoptosis by potentially decreasing the expression of caspases and pro-apoptotic proteins. @entity8 induced ROS generations were reduced on @entity13 exposure. @entity13 significantly promoted the phosphorylation of @entity4 and @entity16 and down-regulated @entity7 , thus activating @entity17 / @entity4 signalling. @entity13 effectively improved the cell viability and inhibited apoptosis of N2a and SH-SY5Y cells via suppression of ROS generation and modulation of PI3K/ @entity4 signalling cascade.

title: Neuroprotection by @entity12 against XXXX anesthesia induced @entity1 involves modulation of @entity17 / @entity4 / @entity7 signalling in N2a and SH-SY5Y cells.

answer: @entity8


abstract: UNASSIGNED: @entity8 , an @entity15 type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown @entity11 following local administration of @entity8 raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of @entity8 are of high value in operative settings and in @entity2 management. The present study aims to investigate if @entity12 ( @entity13 ) could inhibit or prevent @entity8 @entity1 in @entity3 cells (N2a and SH-SY5Y). The viability of N2a and SH-SY5Y cells following exposure to @entity13 (10-50   M) were assessed by @entity0 assay and @entity14 /PI staining. The influence of @entity13 on ROS generation was determined. The expression of apoptotic cascade proteins ( @entity18 , @entity10 , @entity9 , @entity6 , @entity5 ) and @entity4 ( @entity4 , p- @entity4 , @entity16 , p- @entity16 , @entity7 ) were analyzed by western blotting. @entity13 improved the viability of the cells and inhibited apoptosis by potentially decreasing the expression of caspases and pro-apoptotic proteins. @entity8 induced ROS generations were reduced on @entity13 exposure. @entity13 significantly promoted the phosphorylation of @entity4 and @entity16 and down-regulated @entity7 , thus activating @entity17 / @entity4 signalling. @entity13 effectively improved the cell viability and inhibited apoptosis of N2a and SH-SY5Y cells via suppression of ROS generation and modulation of PI3K/ @entity4 signalling cascade.

title: Neuroprotection by XXXX against @entity8 anesthesia induced @entity1 involves modulation of @entity17 / @entity4 / @entity7 signalling in N2a and SH-SY5Y cells.

answer: @entity12


abstract: UNASSIGNED: @entity8 , an @entity15 type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown @entity11 following local administration of @entity8 raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of @entity8 are of high value in operative settings and in @entity2 management. The present study aims to investigate if @entity12 ( @entity13 ) could inhibit or prevent @entity8 @entity1 in @entity3 cells (N2a and SH-SY5Y). The viability of N2a and SH-SY5Y cells following exposure to @entity13 (10-50   M) were assessed by @entity0 assay and @entity14 /PI staining. The influence of @entity13 on ROS generation was determined. The expression of apoptotic cascade proteins ( @entity18 , @entity10 , @entity9 , @entity6 , @entity5 ) and @entity4 ( @entity4 , p- @entity4 , @entity16 , p- @entity16 , @entity7 ) were analyzed by western blotting. @entity13 improved the viability of the cells and inhibited apoptosis by potentially decreasing the expression of caspases and pro-apoptotic proteins. @entity8 induced ROS generations were reduced on @entity13 exposure. @entity13 significantly promoted the phosphorylation of @entity4 and @entity16 and down-regulated @entity7 , thus activating @entity17 / @entity4 signalling. @entity13 effectively improved the cell viability and inhibited apoptosis of N2a and SH-SY5Y cells via suppression of ROS generation and modulation of PI3K/ @entity4 signalling cascade.

title: Neuroprotection by @entity12 against @entity8 anesthesia induced @entity1 involves modulation of XXXX / @entity4 / @entity7 signalling in N2a and SH-SY5Y cells.

answer: @entity17


abstract: UNASSIGNED: @entity8 , an @entity15 type long-acting local anaesthetic is commonly employed for epidural anesthesia and as well for nerve blockades. However, studies have shown @entity11 following local administration of @entity8 raising concerns over the use of the drug. Compounds that could minimize or inhibit toxic effects of @entity8 are of high value in operative settings and in @entity2 management. The present study aims to investigate if @entity12 ( @entity13 ) could inhibit or prevent @entity8 @entity1 in @entity3 cells (N2a and SH-SY5Y). The viability of N2a and SH-SY5Y cells following exposure to @entity13 (10-50   M) were assessed by @entity0 assay and @entity14 /PI staining. The influence of @entity13 on ROS generation was determined. The expression of apoptotic cascade proteins ( @entity18 , @entity10 , @entity9 , @entity6 , @entity5 ) and @entity4 ( @entity4 , p- @entity4 , @entity16 , p- @entity16 , @entity7 ) were analyzed by western blotting. @entity13 improved the viability of the cells and inhibited apoptosis by potentially decreasing the expression of caspases and pro-apoptotic proteins. @entity8 induced ROS generations were reduced on @entity13 exposure. @entity13 significantly promoted the phosphorylation of @entity4 and @entity16 and down-regulated @entity7 , thus activating @entity17 / @entity4 signalling. @entity13 effectively improved the cell viability and inhibited apoptosis of N2a and SH-SY5Y cells via suppression of ROS generation and modulation of PI3K/ @entity4 signalling cascade.

title: Neuroprotection by @entity12 against @entity8 anesthesia induced @entity1 involves modulation of @entity17 / XXXX / @entity7 signalling in N2a and SH-SY5Y cells.

answer: @entity4


abstract: OBJECTIVE: The revised International Prognostic Index (R-IPI) aids in predicting the prognosis of @entity0 with @entity1 ( @entity1 ), but R-IPI yields no significant differences in assessing different subtypes of @entity1 . It is necessary to identify @entity0 with a high-risk of @entity1 and alternative therapy should be delivered as early as possible. METHODS: In total, 144 @entity0 newly diagnosed with @entity1 including 63 @entity1 and 30 healthy controls were enrolled. Peripheral monocytic myeloid-derived suppressor cells (M-MDSC) (CD14(+)HLA(-)DR(low/-)) were detected by flow cytometry and the percentage of monocytes (M  ) was evaluated by completed blood count (CBC). The correlation between M-MDSC% and M  % was statistically analyzed. RESULTS: Compared with healthy controls, significant increase was observed in M-MDSC% and M  % in @entity1 @entity0 (both P<0.001). Significant difference of M-MDSC% was found between GCB- @entity1 and non-GCB- @entity1 @entity0 in both poor (P<0.001) and very good groups (P=0.03), whereas no statistical significance in the good group (P>0.05). The M  % in non-GCB- @entity1 @entity0 was significantly higher than that in GCB- @entity1 counterparts merely in the poor group (P<0.001). Positive correlation was noted between M  % and M-MDSC in all @entity1 @entity0 rather than in healthy controls (r=0.227 P=0.229). CONCLUSION: The percentage of peripheral M   was positively correlated with M-MDSC% in @entity0 with different subtypes and risks of @entity1 . Peripheral M  % and M-MDSC% combined with R-IPI score may be useful for predicting the prognosis of @entity0 newly-diagnosed with @entity1 .

title: Prognostic significance of peripheral monocytic myeloid-derived suppressor cells and monocytes in XXXX newly diagnosed with diffuse large b-cell lymphoma.

answer: @entity0


abstract: BACKGROUND AND AIMS: Peristomal wound @entity2 are common complications of percutaneous endoscopic gastrostomy (PEG). The Funada-style gastropexy device has two parallel needles with a wire loop and suture thread, and was developed about 20 years ago in Japan. This kit has allowed us to perform dual gastropexy very easily; PEG with gastropexy has become a very popular technique in Japan. The present study aimed to compare the advantages and disadvantages of PEG with the gastropexy technique with the standard 'pull' method. METHODS: We retrospectively reviewed 182 consecutive, non-randomized @entity0 undergoing PEG in our hospital, and a comparative analysis was made between the gastropexy (87 @entity0 ) and non-gastropexy (95 @entity0 ) groups. RESULTS: The rates of @entity0 having erythema (11.6% vs. 47.9%; P   <   0.001), exudates (2.3% vs. 14.9%; P   <   0.01) and @entity2 (0% vs. 6.4%; P   =   0.01) in the peristomal area were lower in the gastropexy than in the non-gastropexy group. The rate of minor @entity3 from the peristomal area was higher in the gastropexy than in the non-gastropexy group (12.8% vs. 2.1%; P   <   0.01), but no @entity0 required a blood transfusion. Mean procedure time was longer in the gastropexy group than in the non-gastropexy group (31 vs. 24   min; P   <   0.001). The 30-day mortality rates were 4.7% and 5.3% respectively, and these deaths were not related to the gastrostomy procedure. CONCLUSION: PEG with gastropexy markedly reduces peristomal @entity1 . Although minor @entity3 and a longer procedure time were disadvantages, there were no severe complications. The findings suggested that PEG with Funada-style gastropexy was a safe and feasible method for reducing early complications of PEG.

title: Percutaneous endoscopic gastrostomy with Funada-style gastropexy greatly reduces the risk of XXXX .

answer: @entity2


abstract: Commercially available Ringer's lactate solution has a pH of approximately 6.5. In a situation such as shock, which is normally accompanied by a @entity1 , this additional acid load could have an adverse effect on resuscitation when massive amounts of fluid are required. We prepared a similar solution with a pH of 7.4 and compared the two solutions. Fourteen @entity0 were shocked according to a Wiggers' @entity2 model. Six @entity0 (43%) died during shock, 8 @entity0 survived the model, 4 were resuscitated over a 150-minute observation period to a pulmonary capillary wedge pressure (PCWP) of 8-12 mmHg with Ringer's lactate with a pH of 7.4. The cardiac output, @entity3 levels, amount of fluid required to maintain the PCWP, and arterial and mixed venous pH were measured at 30, 60, 90, 120, and 150 minutes. No significant differences were found except for occasionally higher arterial pH values in the group treated with Ringer's lactate with a pH of 7.4. There was no difference between the groups in any measurement at the end of the observation period or in survival. All @entity0 died within 12 hours of the end of the shock period. Our data indicate that the somewhat acidic pH of standard Ringer's lactate does not adversely affect the adequacy of resuscitation. There is no advantage to using Ringer's lactate with a pH of 7.4.

title: The effect of pH of resuscitative fluids in treatment of severe XXXX .

answer: @entity2


abstract: There is a high incidence of @entity6 in @entity0 after @entity1 or @entity4 . Since circulating white blood cells (WBC) are a vital component of host defense mechanisms, we examined leukocyte responses in @entity2 @entity4 . Twenty adult mongrel @entity2 were anesthetized with 28.6 mg/kg of IV @entity7 . Arterial and venous cannulas were inserted, and after baseline hemodynamic and blood determinations the @entity2 were rapidly bled into a reservoir to a mean arterial pressure of 45 +/- 3 mmHg. The animals were maintained at this pressure for one hour and then resuscitated with twice the volume of shed blood over two hours using Ringer's @entity5 solution. Serial WBC counts after shock were compared to baseline values using Student's t test. In the first few hours after @entity4 the total WBC count falls, while the neutrophil population rises significantly. During the first week following shock and resuscitation, the leukocyte count remains elevated due to a persistent increase in the neutrophil population. The lymphocyte count remains @entity3 . Therefore, changes in the number of WBC after @entity2 @entity4 do not favor the development of @entity6 , because the neutrophil count remains elevated. Whether or not neutrophil function is adequate remains to be determined.

title: The natural leukocyte response to XXXX .

answer: @entity4


abstract: UNASSIGNED: This study evaluated the clinical characteristics, treatment outcomes, and complications of @entity0 with @entity7 ( @entity7 ) in our local Chinese population. @entity0 with @entity7 attending our hospital from 2008 to 2011 were identified and followed up. Their clinical and laboratory features at presentation, as well as their disease progression, treatments, and outcomes were recorded and compared with other reported series. A total of 75 @entity0 with @entity7 were identified. Forty-four were female. Thirty-nine had disease onset between 16 and 35 years of age. The most common presenting features were @entity1 (96%), @entity3 (57.33%), @entity5 (78.67%), and sore throat (49.3%). The acute phase response was marked in most @entity0 , with elevated erythrocyte sedimentation rates (77.05%) and @entity4 levels (84.06%). @entity6 was present in 74.14% of cases, and serum ferritin (SF) levels declined after treatment in most cases. @entity2 were usually transient, but were more severe in 5 @entity0 . Most @entity0 (92%) required corticosteroid therapy; of these, 33.3% also received disease-modifying antirheumatic drugs or immunosuppressive drugs. Sixty-four and 45.33% @entity0 with @entity7 achieved partial and complete remission, respectively, after 2 weeks of treatment, and 92% and 74.67%, respectively, after 1 month. The cumulative relapse rate was 45.3%. @entity0 with @entity7 had complex symptoms with no specific laboratory findings. Reduced SF levels after treatment and @entity2 may be used to follow treatment outcome.

title: Clinical features and prognosis of XXXX : 75 cases from China.

answer: @entity7


abstract: PURPOSE: To investigate the influence of age on the neuromuscular blocking effect of @entity1 . METHODS: 90 @entity0 with ASA I and II were assigned to the following groups according to their age: adults, @entity0 , and @entity0 . Each group was subdivided into three subgroups according to the first dose of @entity1 . @entity0 were administrated at a first dose of @entity1 randomly, and their responses to @entity2 ( @entity2 ) stimulation were observed. When the same degree of the first response (T1) continuously repeats three times, the percentage of T1 inhibition was recorded, and the curve of dose-effect relationship and ED95 were calculated. A second dose of @entity1 was then administrated (total volume 100  g/kg). The recovery phase in each @entity0 was observed upon T1 reaching the maximum blocking effect (100%). RESULTS: Once the maximum blocking effect was reached, @entity0 were intubated. There were 83 cases (92.2%) of @entity0 with grade 1 and 7 (7.8%) @entity0 with grade 2 intubating conditions. ED95 was 59.29, 55.88 and 45.39  g/kg in adults, @entity0 , and @entity0 , respectively. ED95 positively correlated with age. The clinical duration of @entity3 , effective action duration of @entity3 , and in vivo action duration of @entity3 in adults was longer than that in @entity0 (P<0.05), but shorter than in @entity0 (P<0.05). However, there were no significant differences in the recovery index among groups (P>0.05). CONCLUSION: Age influences the neuromuscular blocking effects of @entity1 to a certain extent.

title: Age and the neuromuscular blockading effects of XXXX .

answer: @entity1


abstract: OBJECTIVE: To determine the pathogenesis and characteristics and to assess the long-term effectiveness of polymethylmethacry late (PMMA) vertebroplasty treatment in @entity0 with intravertebral cleft (IVC) in @entity4 . METHODS: A retrospective analysis of radiological and clinical parameters was performed on 388 @entity0 who underwent percutaneous vertebroplasty or kyphoplasty to treat @entity4 from January 2010 to October 2012. IVC sign was observed in the MRI of 47 @entity0 . Postoperative follow-ups were conducted for at least 2 years after surgery. RESULTS: IVC incidence was associated with older age and lower bone mineral density. Other baseline measurements, such as preoperative visual analogue scale and @entity2 Index (ODI), showed no significant difference between IVC and non-IVC @entity1 @entity0 . Vertebral height and kyphotic angle were corrected after percutaneous vertebroplasty or kyphoplasty with no significant difference in outcome between the two procedures. Restored vertebral height collapsed and the kyphotic angle became aggravated during the 2 years following surgery in @entity0 with IVC. Similarly, initial improvements in visual analogue scale and ODI decreased over time. Non-IVC @entity0 ' had a slight recurrence of compression and @entity3 that began to normalize after 1 year. Visual analogue scale and ODI at 2 years' post-surgery was also significantly lower in non-IVC than IVC @entity0 . CONCLUSION: Polymethylmethacrylate vertebroplasty treatment of @entity4 is initially effective for @entity0 with signs of IVC, but compression and @entity3 gradually reoccur. Therefore, we strongly recommend strict observation and follow-up after vertebroplasty.

title: Intravertebral clefts in XXXX of the spine: incidence, characteristics, and therapeutic efficacy.

answer: @entity4


abstract: OBJECTIVE: To correlate the presence of chromosome 1p/19q deletion with the expression of @entity4 mutant @entity2 status in @entity0 , and to explore molecular markers for predicting @entity0 . METHODS: The study included 75 @entity0 (38 @entity3 and 37 @entity1 ). Immunohistochemistry was used to detect the expression of @entity4 mutant @entity2 protein, and fluorescence in situ hybridization (FISH) was employed to detect 1p/19q deletion. RESULTS: Deletion of chromosome 1p and/or 19q was detected in 37 cases (37/75, 49.3%), among which co-deletion of 1p and 19q was seen in 34 cases (closely correlated, P < 0.01). @entity3 WHOIIhad a slightly higher deletion rate than @entity3 WHO III, although without statistical significance. @entity3 had a significantly higher deletion rate of chromosome 1p/19q than @entity1 WHO II and WHO III (P < 0.05). While combined loss of 1p/19q was always detected in @entity3 when FISH was positive, isolated 1p or 19q deletion was only found in @entity1 . The expression of @entity4 mutant @entity2 was detected in 51 of 75 cases (68.0%), in which @entity3 had a higher positive rate than @entity1 . Statistical analysis demonstrated a significant correlation between the expression of @entity4 mutant @entity2 protein and the presence of combined 1p/19q deletion in @entity3 (P < 0.05). CONCLUSIONS: A significant correlation was observed between the expression of @entity4 mutant protein and 1p/19q LOH.Expression of 132H mutant @entity2 protein is the potential biomarker for predicating the presence of 1p/19q deletion in @entity3 .

title: [Correlation of chromosome 1p and 19q status and expression of @entity4 mutant XXXX protein in @entity0 ].

answer: @entity2


abstract: OBJECTIVE: To correlate the presence of chromosome 1p/19q deletion with the expression of @entity4 mutant @entity2 status in @entity0 , and to explore molecular markers for predicting @entity0 . METHODS: The study included 75 @entity0 (38 @entity3 and 37 @entity1 ). Immunohistochemistry was used to detect the expression of @entity4 mutant @entity2 protein, and fluorescence in situ hybridization (FISH) was employed to detect 1p/19q deletion. RESULTS: Deletion of chromosome 1p and/or 19q was detected in 37 cases (37/75, 49.3%), among which co-deletion of 1p and 19q was seen in 34 cases (closely correlated, P < 0.01). @entity3 WHOIIhad a slightly higher deletion rate than @entity3 WHO III, although without statistical significance. @entity3 had a significantly higher deletion rate of chromosome 1p/19q than @entity1 WHO II and WHO III (P < 0.05). While combined loss of 1p/19q was always detected in @entity3 when FISH was positive, isolated 1p or 19q deletion was only found in @entity1 . The expression of @entity4 mutant @entity2 was detected in 51 of 75 cases (68.0%), in which @entity3 had a higher positive rate than @entity1 . Statistical analysis demonstrated a significant correlation between the expression of @entity4 mutant @entity2 protein and the presence of combined 1p/19q deletion in @entity3 (P < 0.05). CONCLUSIONS: A significant correlation was observed between the expression of @entity4 mutant protein and 1p/19q LOH.Expression of 132H mutant @entity2 protein is the potential biomarker for predicating the presence of 1p/19q deletion in @entity3 .

title: [Correlation of chromosome 1p and 19q status and expression of XXXX mutant @entity2 protein in @entity0 ].

answer: @entity4


abstract: OBJECTIVE: To correlate the presence of chromosome 1p/19q deletion with the expression of @entity4 mutant @entity2 status in @entity0 , and to explore molecular markers for predicting @entity0 . METHODS: The study included 75 @entity0 (38 @entity3 and 37 @entity1 ). Immunohistochemistry was used to detect the expression of @entity4 mutant @entity2 protein, and fluorescence in situ hybridization (FISH) was employed to detect 1p/19q deletion. RESULTS: Deletion of chromosome 1p and/or 19q was detected in 37 cases (37/75, 49.3%), among which co-deletion of 1p and 19q was seen in 34 cases (closely correlated, P < 0.01). @entity3 WHOIIhad a slightly higher deletion rate than @entity3 WHO III, although without statistical significance. @entity3 had a significantly higher deletion rate of chromosome 1p/19q than @entity1 WHO II and WHO III (P < 0.05). While combined loss of 1p/19q was always detected in @entity3 when FISH was positive, isolated 1p or 19q deletion was only found in @entity1 . The expression of @entity4 mutant @entity2 was detected in 51 of 75 cases (68.0%), in which @entity3 had a higher positive rate than @entity1 . Statistical analysis demonstrated a significant correlation between the expression of @entity4 mutant @entity2 protein and the presence of combined 1p/19q deletion in @entity3 (P < 0.05). CONCLUSIONS: A significant correlation was observed between the expression of @entity4 mutant protein and 1p/19q LOH.Expression of 132H mutant @entity2 protein is the potential biomarker for predicating the presence of 1p/19q deletion in @entity3 .

title: [Correlation of chromosome 1p and 19q status and expression of @entity4 mutant @entity2 protein in XXXX ].

answer: @entity0


abstract: PURPOSE: Coexistence of @entity3 ( @entity3 ) and @entity4 ( @entity4 ) is extremely rare. The purpose of this article is to analyze the clinical features, image findings, and therapeutic outcomes of concomitant @entity3 and @entity4 in China. MATERIALS AND METHODS: Detailed clinical records of 3 Chinese @entity0 with concomitant @entity3 and @entity4 were reviewed, including their clinical history, symptoms and signs, ultrasonography, computed tomography (CT), and @entity1 therapy. RESULTS: Among the 3 @entity0 , were 2 @entity0 and 1 @entity0 , aged 42, 49, and 48 years, respectively. The right orbit was involved in 1 @entity0 and both orbits in 2 @entity0 . In addition to showing the typical features of @entity4 , such as @entity2 , upper eyelid retraction, and enlarged extraocular muscles with tendon sparing, all 3 @entity0 showed ambiguous soft tissue masses in one or both orbits. Pathologic examination after biopsy of the mass in 1 @entity0 confirmed the diagnosis of lymphatic @entity3 . All the @entity0 responded extremely well to @entity1 treatment. CONCLUSIONS: Although rare, a simultaneous coexistence of @entity3 and @entity4 can occur. Therefore, it is important for clinicians to be aware of the potential for concomitant @entity3 and @entity4 .

title: Concomitant XXXX and @entity4 .

answer: @entity3


abstract: PURPOSE: Coexistence of @entity3 ( @entity3 ) and @entity4 ( @entity4 ) is extremely rare. The purpose of this article is to analyze the clinical features, image findings, and therapeutic outcomes of concomitant @entity3 and @entity4 in China. MATERIALS AND METHODS: Detailed clinical records of 3 Chinese @entity0 with concomitant @entity3 and @entity4 were reviewed, including their clinical history, symptoms and signs, ultrasonography, computed tomography (CT), and @entity1 therapy. RESULTS: Among the 3 @entity0 , were 2 @entity0 and 1 @entity0 , aged 42, 49, and 48 years, respectively. The right orbit was involved in 1 @entity0 and both orbits in 2 @entity0 . In addition to showing the typical features of @entity4 , such as @entity2 , upper eyelid retraction, and enlarged extraocular muscles with tendon sparing, all 3 @entity0 showed ambiguous soft tissue masses in one or both orbits. Pathologic examination after biopsy of the mass in 1 @entity0 confirmed the diagnosis of lymphatic @entity3 . All the @entity0 responded extremely well to @entity1 treatment. CONCLUSIONS: Although rare, a simultaneous coexistence of @entity3 and @entity4 can occur. Therefore, it is important for clinicians to be aware of the potential for concomitant @entity3 and @entity4 .

title: Concomitant @entity3 and XXXX .

answer: @entity4


abstract: @entity2 is considered a disease of high prevalence and a constant problem in public health. @entity5 ( @entity4 ) are substances that have been the target of recent studies aiming to control or treat caries. OBJECTIVE: The aim of this in vitro study was to evaluate the efficacy of a treatment with @entity3 , under cariogenic challenge, to minimize or even prevent the onset of caries in the enamel and dentin. MATERIAL AND METHODS: Blocks of enamel and dentin (6.0x6.0 mm) were obtained from @entity0 central incisors, polished, and selected by analysis of surface microhardness (SH). The blocks were randomly divided into 3 groups (n=15), according to the following treatments: GC (control), @entity3 ( @entity3 ), GF ( @entity1 - 1,000 ppm). The blocks were subjected to 6 daily pH cycles for 8 days. Within the daily cycling, the specimens were stored in buffered solution. The blocks were then analyzed for perpendicular and surface hardness and polarized light microscopy. RESULTS: The means were subjected to statistical analysis using the ANOVA and Fisher's PLSD tests (p<0.05). For enamel SH, GF showed the highest hardness values. In the dentin, GF was also the one that showed higher hardness values, followed by @entity3 . Regarding the cross-sectional hardness values, all groups behaved similarly in both the enamel and dentin. The samples that were treated with @entity3 and @entity1 (GF) showed statistically higher values than the control. CONCLUSION: Based on the data obtained in this in vitro study, it is suggested that @entity3 inhibits demineralization of artificial @entity2 in both the enamel and dentin, but in a different scale in each structure and in a smaller scale when compared to @entity1 .

title: Effectiveness of plant-derived XXXX on demineralization on enamel and dentin under artificial cariogenic challenge.

answer: @entity5


abstract: BACKGROUND: Generally, in retrospective studies, favourable short- and long-term outcomes for @entity0 after lung lobectomy for early stage @entity4 ( @entity4 ) using video-assisted thoracoscopic surgery (VATS) have been reported. However, the interpretation of lung lobectomy outcomes may be biased in retrospective settings. METHODS: We retrospectively reviewed @entity0 who underwent lung lobectomy for cT1-2N0M0 @entity4 from 2001 to 2010. The outcomes of @entity0 who underwent VATS lobectomy were compared to those who underwent open lobectomy before and after performing propensity score matching. Preoperative covariates were entered when developing the propensity score-matching model. RESULTS: This study reviewed the outcomes of 101 VATS @entity0 and 184 open lobectomy @entity0 . Before propensity score matching, the VATS group had a higher mean age (p  <  0.0001), smaller solid @entity1 size (p  =  0.0042), similar whole @entity1 size (p  =  0.2082), and larger @entity1 -disappearance ratio (p  =  0.0007). The VATS group had a shorter mean operation time (p  =  0.0002), less @entity2 (p  <  0.0001), shorter @entity3 (p  =  0.0002), and shorter hospital stay (p  <  0.0001). As for long-term outcomes, the VATS group had higher disease-free, disease-specific, and overall survival rates (p values by log-rank test: 0.0049, 0.0154, and 0.032, respectively). After propensity score matching, all differences, except operation time, @entity2 , @entity3 , and hospital stay, were no longer significant. CONCLUSIONS: VATS lobectomy is less invasive than open lobectomy, but in terms of survival outcomes, VATS lobectomy was oncologically equivalent to open lobectomy. The oncological benefit of VATS reported by retrospective studies might be overestimated.

title: Long-Term Outcomes of Open and Video-Assisted Thoracoscopic Lung Lobectomy for the Treatment of Early Stage XXXX are Similar: A Propensity-Matched Study.

answer: @entity4


abstract: UNASSIGNED: @entity0 with penetrating wounds to the neck present with overt symptoms and/or signs or are asymptomatic or modestly/moderately symptomatic. With overt symptoms and/or signs, immediate resuscitation and an emergency operation are appropriate. Asymptomatic @entity0 or those with modest or moderate symptoms and/or signs undergo observation or a diagnostic evaluation to avoid the 45  % "negative" exploration rate documented in the past (denominator  =  all @entity0 ). Asymptomatic @entity0 with penetration of the platysma muscle, but no signs of a @entity3 , should undergo serial physical examinations every 6-8 for 24-36  h before discharge. Noncontrast CT does not add to the accuracy of serial physical examinations. In stable @entity0 with a variety of modest/moderate symptoms or signs possibly related to an @entity4 , CT-arteriography has become the diagnostic modality of choice. @entity0 with possible @entity1 to the cervical esophagus are often still evaluated with a Gastrografin swallow and, if needed, a "thin" barium swallow prior to fiberoptic esophagoscopy. CT-esophagograms are likely to replace these time-honored studies in the near future. Over 85  % of @entity0 with @entity1 to the @entity2 present with overt symptoms or signs, while the remainder have historically been evaluated with laryngoscopy and fiberoptic bronchoscopy. Again, cervical multislice CT is likely to replace these studies. Operative repair of the carotid artery with 6-0 @entity5 sutures requires heparinization and shunting on rare occasions. Both the @entity2 and esophagus are repaired with 3-0 absorbable sutures, and tracheostomy and esophageal diversion are used in only large and/or complex @entity1 . Sternal head or sternocleiodomastoid interposition flaps are used when combined visceral and @entity3 are present.

title: Penetrating Cervical @entity1 : "Current Concepts in Penetrating XXXX ", IATSIC Symposium, International Surgical Society, Helsinki, Finland, August 25-29, 2013.

answer: @entity1