abstract: AIMS: The objective of this study was to examine factors that predict antiretroviral therapy (ART) access among eligible, @entity4 -positive @entity1 maintenance treatment ( @entity3 ) clients. We also tested the hypothesis that sustained @entity3 participation increases the likelihood of accessing ART. DESIGN: A nation-wide cohort study conducted from 1 March 2004 to 31 December 2011. SETTING: @entity3 clients were followed from the time of their enrolment in China's national @entity3 programme until their death or the study end date. @entity0 : Our cohort comprised 7111 ART-eligible, @entity4 -positive @entity3 clients, 49.2% of whom remained ART-naive and 50.8% of whom received ART. MEASUREMENTS: Demographic variables, drug use history, @entity3 programme participation and @entity4 -related clinical characteristics of study @entity0 who remained naive to ART and those who accessed ART were compared by univariate and multivariable analysis. FINDINGS: Predictors of accessing ART among this cohort included being retained in @entity3 at the time of first meeting ART eligibility [adjusted odds ratio (AOR)   =   1.84, confidence interval (CI)   =   1.54-2.21, P   <   0.001] compared to meeting ART eligibility before entering @entity3 (AOR   =   0.98, CI   =   0.80-1.21, P   =   0.849) or previously entering @entity3 and dropping out before meeting ART eligibility. Additional predictors were @entity2  <=200 cells/ l when ART-eligibility requirement was first met (AOR   =   1.81, CI   =   1.61-2.05, P   <   0.001 compared to @entity2   =   201-350 cells/ l), and being in a stable partner relationship (married/cohabitating: AOR   =   1.14, CI   =   1.01-1.28, P   =   0.030). CONCLUSIONS: Retained participation in @entity1 maintenance treatment increases the likelihood that eligible clients will access antiretroviral therapy. These results highlight the potential benefit of colocalization of @entity1 maintenance treatment and antiretroviral therapy services in a 'one-stop-shop' model.

title: Predictors of accessing antiretroviral therapy among XXXX -positive drug users in China's National @entity1 Maintenance Treatment Programme.

answer: @entity4


abstract: AIMS: The objective of this study was to examine factors that predict antiretroviral therapy (ART) access among eligible, @entity4 -positive @entity1 maintenance treatment ( @entity3 ) clients. We also tested the hypothesis that sustained @entity3 participation increases the likelihood of accessing ART. DESIGN: A nation-wide cohort study conducted from 1 March 2004 to 31 December 2011. SETTING: @entity3 clients were followed from the time of their enrolment in China's national @entity3 programme until their death or the study end date. @entity0 : Our cohort comprised 7111 ART-eligible, @entity4 -positive @entity3 clients, 49.2% of whom remained ART-naive and 50.8% of whom received ART. MEASUREMENTS: Demographic variables, drug use history, @entity3 programme participation and @entity4 -related clinical characteristics of study @entity0 who remained naive to ART and those who accessed ART were compared by univariate and multivariable analysis. FINDINGS: Predictors of accessing ART among this cohort included being retained in @entity3 at the time of first meeting ART eligibility [adjusted odds ratio (AOR)   =   1.84, confidence interval (CI)   =   1.54-2.21, P   <   0.001] compared to meeting ART eligibility before entering @entity3 (AOR   =   0.98, CI   =   0.80-1.21, P   =   0.849) or previously entering @entity3 and dropping out before meeting ART eligibility. Additional predictors were @entity2  <=200 cells/ l when ART-eligibility requirement was first met (AOR   =   1.81, CI   =   1.61-2.05, P   <   0.001 compared to @entity2   =   201-350 cells/ l), and being in a stable partner relationship (married/cohabitating: AOR   =   1.14, CI   =   1.01-1.28, P   =   0.030). CONCLUSIONS: Retained participation in @entity1 maintenance treatment increases the likelihood that eligible clients will access antiretroviral therapy. These results highlight the potential benefit of colocalization of @entity1 maintenance treatment and antiretroviral therapy services in a 'one-stop-shop' model.

title: Predictors of accessing antiretroviral therapy among @entity4 -positive drug users in China's National XXXX Maintenance Treatment Programme.

answer: @entity1


abstract: UNASSIGNED: BackgroundWe investigated whether routine elective irradiation of a clinically negative @entity4 ( @entity4 ) is necessary for @entity0 with locally advanced @entity2 and anal canal invasion (ACI).MethodsWe reviewed retrospectively 1,246 @entity0 with locally advanced @entity3 managed using preoperative or postoperative chemoradiotherapy and radical surgery between 2001 and 2011. The @entity0   @entity4 was clinically negative at presentation and @entity4 irradiation was not performed. ACI was defined as the lower edge of the @entity2 being within 3 cm of the anal verge. @entity0 were divided into two groups, those with ACI (n  =  189, 15.2%) and without ACI (n  =  1,057, 84.8%).ResultsThe follow-up period was a median of 66 months (range, 3  142 months). Among the 1,246 @entity0 , 10 developed @entity4 recurrence; 7 with ACI and 3 without ACI. The actuarial @entity4 recurrence rate at 5 years was 0.7%; 3.5% and 0.2% in @entity0 with and without ACI, respectively (p  <  0.001). Isolated @entity4 recurrence occurred in three @entity0 , all of whom had @entity1 . These three @entity0 received curative intent local treatments, and one was alive with no evidence of disease 10 years after @entity4 recurrence. Salvage treatments in the other two @entity0 controlled successfully the @entity4 recurrence for >5 years, but they developed second @entity2 or pelvic and distant recurrences. Seven @entity0 with non-isolated @entity4 recurrence died of disease at 5  22 months after @entity4 recurrence.ConclusionThe low @entity4 recurrence rate even with ACI and the feasibility of salvage of isolated @entity4 recurrence indicated that routine elective @entity4 irradiation is not necessary for @entity2 with ACI.

title: Is elective inguinal radiotherapy necessary for locally advanced XXXX invading anal canal?

answer: @entity3


abstract: BACKGROUND AND OBJECTIVE: @entity4 is a @entity0 with increasing incidence, easy prenatal diagnosis and extremely variable postnatal outcomes. Our objective was to systematically review the evidence regarding the association between prenatal ultrasound signs (intraabdominal bowel dilatation [IABD], extraabdominal bowel dilatation, @entity5 [ @entity5 ], bowel wall thickness, @entity3 , and small for gestational age) and perinatal outcomes in @entity4 (bowel @entity2 , intra uterine @entity1 , @entity1 , time to full enteral feeding, length of total parenteral nutrition and length of in hospital stay). METHODS: Medline, Embase, and Cochrane databases were searched electronically. Studies exploring the association between antenatal ultrasound signs and outcomes in @entity4 were considered suitable for inclusion. Two reviewers independently extracted relevant data regarding study characteristics and pregnancy outcome. All meta-analyses were computed using individual data random-effect logistic regression, with single study as the cluster unit. RESULTS: Twenty-six studies, including 2023 fetuses, were included. We found significant positive associations between IABD and bowel @entity2 (odds ratio [OR]: 5.48, 95% confidence interval [CI] 3.1-9.8), @entity3 and bowel @entity2 (OR: 3.76, 95% CI 1.7-8.3), and @entity5 (OR: 5.58, 95% CI 1.3-24.1). No other ultrasound sign was significantly related to any other outcome. CONCLUSIONS: IABD, @entity3 , and @entity5 can be used to an extent to identify a subgroup of neonates with a prenatal diagnosis of @entity4 at higher risk to develop postnatal complications. Data are still inconclusive on the predictive ability of several signs combined, and large prospective studies are needed to improve the quality of prenatal counseling and the neonatal care for this condition.

title: Prenatal Risk Factors and Outcomes in XXXX : A Meta-Analysis.

answer: @entity4


abstract: BACKGROUND: Cardiac-committed cells and biomimetic scaffolds independently improve the therapeutic efficacy of stem cells. In this study we tested the long-term effects of their combination. METHODS: Eighty immune-deficient @entity1 underwent permanent coronary artery ligation. Five to 7 weeks later, those with an echocardiographically measured ejection fraction (EF)  <=55% were re-operated on and randomly allocated to receive a cell-free fibrin patch (n = 25), a fibrin patch loaded with 700,000 @entity0 embryonic stem cells (ESC) pre-treated to promote early cardiac differentiation (SSEA-1(+) progenitors [n = 30]), or to serve as sham-operated animals (n = 25). Left ventricular function was assessed by echocardiography at baseline and every month thereafter until 4 months. Hearts were then processed for assessment of @entity3 and angiogenesis and a 5-component @entity4 score was constructed by integrating the absolute change in left ventricular end-systolic volume (LVESV) between 4 months and baseline, and the quantitative polymerase chain reaction (qPCR)-based expression of @entity5 , myosin heavy chain 7 and periostin. All data were recorded and analyzed in a blinded manner. RESULTS: The cell-treated group consistently yielded better functional outcomes than the sham-operated group (p = 0.002 for EF; p = 0.01 for LVESV). Angiogenesis in the border zone was also significantly greater in the cell-fibrin group (p = 0.006), which yielded the lowest @entity4 score (p = 0.04 vs sham). Engrafted progenitors were only detected shortly after transplantation; no grafted cells were identified after 4 months. There was no @entity2 identified. CONCLUSIONS: A fibrin scaffold loaded with ESC-derived cardiac progenitors resulted in sustained improvement in contractility and attenuation of remodeling without sustained donor cell engraftment. A paracrine effect, possibly on innate reparative responses, is a possible mechanism for this enduring effect.

title: Long-term functional benefits of XXXX embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold.

answer: @entity0


abstract: UNASSIGNED: This is a 10-year retrospective study of @entity0 with an isolated unilateral @entity5 reconstructed with an autogenous iliac crest bone graft. The following inclusion criteria applied: isolated @entity5 without involvement of the orbital rim or other @entity4 , pre-/post-operative ophthalmological/orthoptic follow-up, pre-operative CT. Variables recorded were @entity0 age and gender, aetiology of injury, time to surgery, follow-up period, surgical morbidity, @entity3 pre- and post-operatively (Hess test), eyelid position, visual acuity, and the presence of en-/or exophthalmos (Hertel exophthalmometer). Twenty @entity0 met the inclusion criteria. The mean age was 29 years. The mean follow up period was 26 months. No @entity0 experienced significant donor site morbidity. There were no episodes of @entity2 or graft extrusion. Three @entity0 had @entity3 in extremes of vision post-operatively, but no interference with activities of daily living. One @entity0 had post-operative enophthalmos. Isolated orbital @entity5 may be safely and predictably reconstructed using autogenous iliac crest bone. The rate of complications in the group of @entity0 studied was low. The value of pre- and post-operative ophthalmology consultation cannot be underestimated, and should be considered the standard of care in all @entity0 with orbitozygomatic @entity1 , in particular those with @entity5 .

title: Reconstruction of orbital floor XXXX with autogenous iliac crest bone: A retrospective study including maxillofacial and ophthalmology perspectives.

answer: @entity5


abstract: BACKGROUND: @entity0 with @entity4 are traditionally treated with fronto-orbital advancement to correct @entity3 and @entity1 . Alternatively, endoscopic-assisted treatment comprises narrow ostectomy of the fused suture followed by postoperative helmet therapy. Here we compare the preoperative and 1-year postoperative results in open versus endoscopic repairs. METHODS: We reviewed preoperative and 1-year postoperative three-dimensional reconstructed computed tomography scans of @entity0 treated for nonsyndromic @entity4 by either open (n = 15) or endoscopic (n = 13) technique. @entity3 was assessed by interzygomaticofrontal distance and intercanthal distance. @entity1 was assessed by 2 independent angles: first, an axial-plane two-dimensional angle between zygomaticofrontal suture bilaterally and the @entity2 (ZFR-G-ZFL); second, an interfrontal angle (IFA) between the most anterior point from a reconstructed midsagittal plane and supraorbital notch bilaterally. Age-matched scans of unaffected @entity0 (n = 28) served as controls for each postoperative scan. RESULTS: @entity0 with open repair (9.5    1.8 months) were older at time of surgery than @entity0 with endoscopic repairs (3.3    0.4 months) (P = 0.004). Male-to-female ratios were equivalent at roughly 7:3 in both groups. Preoperatively, the endoscopic group had worse @entity3 and ZFR-G-ZFL than the open group (P  <= 0.04). After accounting for preoperative differences, all of the postoperative measurements (ie, interzygomaticofrontal distance, intercanthal distance, ZFR-G-ZFL angle, IFA) of the 2 groups were statistically equivalent (P >=  0.135). @entity1 was significantly improved after repair in both the open (8 degrees [ZFR-G-ZFL] and 18 degrees [IFA]) and endoscopic (13 degrees [ZFR-G-ZFL] and 16 degrees [IFA]) groups (P < 0.001). Postoperative measures in both groups were equivalent to controls (0.12 < P < 0.89). Intrarater reliability ranged from 0.93 to 0.99 for all measurements. CONCLUSION: Our retrospective series shows that endoscopic and open repairs of @entity4 are equivalent in improving @entity3 and @entity1 at 1-year follow-up. Additional studies are necessary to better define minor differences in morphology, which may result from the different techniques.

title: Are Endoscopic and Open Treatments of @entity1 Equivalent in Treating @entity1 and XXXX ?

answer: @entity3


abstract: BACKGROUND: @entity0 with @entity4 are traditionally treated with fronto-orbital advancement to correct @entity3 and @entity1 . Alternatively, endoscopic-assisted treatment comprises narrow ostectomy of the fused suture followed by postoperative helmet therapy. Here we compare the preoperative and 1-year postoperative results in open versus endoscopic repairs. METHODS: We reviewed preoperative and 1-year postoperative three-dimensional reconstructed computed tomography scans of @entity0 treated for nonsyndromic @entity4 by either open (n = 15) or endoscopic (n = 13) technique. @entity3 was assessed by interzygomaticofrontal distance and intercanthal distance. @entity1 was assessed by 2 independent angles: first, an axial-plane two-dimensional angle between zygomaticofrontal suture bilaterally and the @entity2 (ZFR-G-ZFL); second, an interfrontal angle (IFA) between the most anterior point from a reconstructed midsagittal plane and supraorbital notch bilaterally. Age-matched scans of unaffected @entity0 (n = 28) served as controls for each postoperative scan. RESULTS: @entity0 with open repair (9.5    1.8 months) were older at time of surgery than @entity0 with endoscopic repairs (3.3    0.4 months) (P = 0.004). Male-to-female ratios were equivalent at roughly 7:3 in both groups. Preoperatively, the endoscopic group had worse @entity3 and ZFR-G-ZFL than the open group (P  <= 0.04). After accounting for preoperative differences, all of the postoperative measurements (ie, interzygomaticofrontal distance, intercanthal distance, ZFR-G-ZFL angle, IFA) of the 2 groups were statistically equivalent (P >=  0.135). @entity1 was significantly improved after repair in both the open (8 degrees [ZFR-G-ZFL] and 18 degrees [IFA]) and endoscopic (13 degrees [ZFR-G-ZFL] and 16 degrees [IFA]) groups (P < 0.001). Postoperative measures in both groups were equivalent to controls (0.12 < P < 0.89). Intrarater reliability ranged from 0.93 to 0.99 for all measurements. CONCLUSION: Our retrospective series shows that endoscopic and open repairs of @entity4 are equivalent in improving @entity3 and @entity1 at 1-year follow-up. Additional studies are necessary to better define minor differences in morphology, which may result from the different techniques.

title: Are Endoscopic and Open Treatments of XXXX Equivalent in Treating @entity1 and @entity3 ?

answer: @entity1


abstract: BACKGROUND: @entity0 with @entity4 are traditionally treated with fronto-orbital advancement to correct @entity3 and @entity1 . Alternatively, endoscopic-assisted treatment comprises narrow ostectomy of the fused suture followed by postoperative helmet therapy. Here we compare the preoperative and 1-year postoperative results in open versus endoscopic repairs. METHODS: We reviewed preoperative and 1-year postoperative three-dimensional reconstructed computed tomography scans of @entity0 treated for nonsyndromic @entity4 by either open (n = 15) or endoscopic (n = 13) technique. @entity3 was assessed by interzygomaticofrontal distance and intercanthal distance. @entity1 was assessed by 2 independent angles: first, an axial-plane two-dimensional angle between zygomaticofrontal suture bilaterally and the @entity2 (ZFR-G-ZFL); second, an interfrontal angle (IFA) between the most anterior point from a reconstructed midsagittal plane and supraorbital notch bilaterally. Age-matched scans of unaffected @entity0 (n = 28) served as controls for each postoperative scan. RESULTS: @entity0 with open repair (9.5    1.8 months) were older at time of surgery than @entity0 with endoscopic repairs (3.3    0.4 months) (P = 0.004). Male-to-female ratios were equivalent at roughly 7:3 in both groups. Preoperatively, the endoscopic group had worse @entity3 and ZFR-G-ZFL than the open group (P  <= 0.04). After accounting for preoperative differences, all of the postoperative measurements (ie, interzygomaticofrontal distance, intercanthal distance, ZFR-G-ZFL angle, IFA) of the 2 groups were statistically equivalent (P >=  0.135). @entity1 was significantly improved after repair in both the open (8 degrees [ZFR-G-ZFL] and 18 degrees [IFA]) and endoscopic (13 degrees [ZFR-G-ZFL] and 16 degrees [IFA]) groups (P < 0.001). Postoperative measures in both groups were equivalent to controls (0.12 < P < 0.89). Intrarater reliability ranged from 0.93 to 0.99 for all measurements. CONCLUSION: Our retrospective series shows that endoscopic and open repairs of @entity4 are equivalent in improving @entity3 and @entity1 at 1-year follow-up. Additional studies are necessary to better define minor differences in morphology, which may result from the different techniques.

title: Are Endoscopic and Open Treatments of @entity1 Equivalent in Treating XXXX and @entity3 ?

answer: @entity1


abstract: BACKGROUND: Sexual health concerns in @entity1 survivors are often unaddressed by providers. Study objectives were to assess @entity1 survivors' reported rates of communication with oncology providers about sexual health, preference for such communication with their oncology or primary care providers (PCPs), and factors associated with these communication rates and preferences. METHODS: Sixty-six @entity0 attending a @entity1 survivorship clinic were asked how often their oncologist addressed and initiated discussion about sexual functioning and whether they wanted their oncologist or @entity4 to ask about their sexual health. We also assessed whether various sociodemographic characteristics and levels of @entity3 , @entity2 , and sexual satisfaction were associated with survivors' sexual health communication rates and preferences. RESULTS: 41% of @entity0 wanted their oncologist to ask about sexual health and 58% of @entity0 wanted their PCP to ask about sexual health. Over 90% of @entity0 reported that their oncologist infrequently addressed sexual health concerns and that their oncologist was unlikely to initiate such discussions. Education level influenced whether @entity0 wanted their oncologist to ask about sexual health. Age, education level, and insurance type influenced whether @entity0 wanted their PCP to ask about sexual health. Levels of @entity3 , @entity2 , and sexual satisfaction were not associated with communication rates or preferences. CONCLUSIONS: @entity0 attending a survivorship clinic reported infrequent communication about sexual health with their oncology providers, despite wanting their providers to ask about sexual health concerns.

title: Sexual health communication between XXXX survivors and providers: how frequently does it occur and which providers are preferred?

answer: @entity1


abstract: BACKGROUND: Early tracheostomy may decrease the duration of mechanical ventilation, sedation exposure, and intensive care stay, possibly resulting in improved clinical outcomes, but the evidence is conflicting. METHODS: Systematic review and meta-analysis of randomized trials in @entity0 allocated to tracheostomy within 10 days of start of mechanical ventilation was compared with placement of tracheostomy after 10 days if still required. Medline, EMBASE, the Cochrane Controlled Clinical Trials Register, and Google Scholar were searched for eligible trials. The co-primary outcomes were mortality within 60 days, and duration of mechanical ventilation, sedation, and intensive care unit stay. Secondary outcomes were the number of tracheostomy procedures performed, and incidence of @entity1 ( @entity1 ). Outcomes are described as relative risk or weighted mean difference with 95% confidence intervals. RESULTS: Of note, 4482 publications were identified and 14 trials enrolling 2406 @entity0 were included. Tracheostomy within 10 days was not associated with any difference in mortality [risk ratio (RR): 0.93 (0.83-1.05)]. There were no differences in duration of mechanical ventilation [-0.19 days (-1.13-0.75)], intensive care stay [-0.83 days (-2.05-0.40)], or incidence of @entity1 . However, duration of sedation was reduced in the early tracheostomy groups [-2.78 days (-3.68 to -1.88)]. More tracheostomies were performed in @entity0 randomly assigned to receive early tracheostomy [RR: 2.53 (1.18-5.40)]. CONCLUSION: We found no evidence that early (within 10 days) tracheostomy reduced mortality, duration of mechanical ventilation, intensive care stay, or @entity1 . Early tracheostomy leads to more procedures and a shorter duration of sedation.

title: Effect of early tracheostomy on resource utilization and clinical outcomes in critically ill XXXX : meta-analysis of randomized controlled trials.

answer: @entity0


abstract: The prognosis of @entity1 with metastatic @entity0 in particular with an involvement of the liver has to be regarded as rather unfavourable. Up today no convincing therapy for @entity1 with @entity0 and liver @entity2 could be found. From 1982 to 1991 42 @entity1 with suspicion on liver @entity2 of a primary @entity0 were laparotomized. At that time 20 @entity1 already had an extrahepatic formation of @entity2 . In contrast to the preexaminations an histologically benign liver @entity3 was intraoperatively verified in 6 @entity1 . In the other 36 @entity1 the operation was finished in 9 cases as explorative laparotomy (group A) because of extensive intra- and @entity4 . In 19 cases an arterial catheter system with subcutaneous port was implanted (group B). Partial liver resection combined with intraarterial catheter implantation was performed in 8 @entity1 (group C). Postoperatively 27 @entity1 monthly received a regional combined chemotherapy (groups B+C); a modified FAM scheme ( @entity7 : 1000 mg/12 h/d/2 d, @entity5 : 20 mg/12 h/d/3 d, @entity6 : 10 mg/2 h/d/1 d) was used. Response could be documented in 12 out of 17 evaluable @entity1 (70.6%). A median overall postoperative survival time of 14.5 months for all @entity1 in case of a proved liver @entity2 was calculated. A prolongation could not be realized, neither in @entity1 with partial liver resection with regional therapy (group C) nor in @entity1 with an intraarterial chemotherapy (group B). Only in exceptional cases a successful regional chemotherapy could influence the course favourable.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Regional therapy XXXX liver @entity2 ].

answer: @entity0


abstract: The prognosis of @entity1 with metastatic @entity0 in particular with an involvement of the liver has to be regarded as rather unfavourable. Up today no convincing therapy for @entity1 with @entity0 and liver @entity2 could be found. From 1982 to 1991 42 @entity1 with suspicion on liver @entity2 of a primary @entity0 were laparotomized. At that time 20 @entity1 already had an extrahepatic formation of @entity2 . In contrast to the preexaminations an histologically benign liver @entity3 was intraoperatively verified in 6 @entity1 . In the other 36 @entity1 the operation was finished in 9 cases as explorative laparotomy (group A) because of extensive intra- and @entity4 . In 19 cases an arterial catheter system with subcutaneous port was implanted (group B). Partial liver resection combined with intraarterial catheter implantation was performed in 8 @entity1 (group C). Postoperatively 27 @entity1 monthly received a regional combined chemotherapy (groups B+C); a modified FAM scheme ( @entity7 : 1000 mg/12 h/d/2 d, @entity5 : 20 mg/12 h/d/3 d, @entity6 : 10 mg/2 h/d/1 d) was used. Response could be documented in 12 out of 17 evaluable @entity1 (70.6%). A median overall postoperative survival time of 14.5 months for all @entity1 in case of a proved liver @entity2 was calculated. A prolongation could not be realized, neither in @entity1 with partial liver resection with regional therapy (group C) nor in @entity1 with an intraarterial chemotherapy (group B). Only in exceptional cases a successful regional chemotherapy could influence the course favourable.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Regional therapy @entity0 liver XXXX ].

answer: @entity2


abstract: PURPOSE: To evaluate the effectiveness of image guided beam gating for PBS liver treatments under realistic breathing conditions. METHODS: We have previously proposed a Beams' Eye View ( @entity3 ) X-ray image system as an online motion monitoring device for deriving a gating signal for PBS proton therapy. Using dedicated 4D dose calculations (4DDC), in this work we have simulated gated liver treatments using three amplitude-based gating windows (10/5/3mm) based on motion extracted from @entity3 imaging of fiducial markers or the diaphragm. In order to improve motion mitigation, @entity3 guided gating has also been combined with either volumetric (VS) or layered (LS) rescanning. Nine 4DCT(MRI) liver data-sets have been used for the investigation, which not only consider realistic @entity0 geometries but also motion variations between different breathing cycles. All 4D plans have been quantified in terms of plan homogeneity in the @entity2 (D5-D95), the total estimated treatment time and the beam-on duty cycle. RESULTS: Neither gating nor rescanning can fully retrieve a comparable plan homogeneity to the static case, and considerable reductions of the duty cycle (<10%) were observed as a Result motion variations when small gating windows are used. However, once combined with rescanning, dose homogeneity within 1% of the static plan could be achieved with reasonable prolongation of the treatment time for all 9 subjects. No differences were observed between the efficacy of layered or volumetric re-scanning, or of gating signals extracted from fiducial or diaphragm motions. However, layered rescanning may be preferred over volumetric rescanning when performed in combination with gating as it is generally more time-efficient and dosimetrically robust to @entity0 and motion variations CONCLUSION: Combining @entity3 beam gating with rescanning is an efficient and effective approach to treating @entity1 , and is equally effective if either the diaphragm or fiducial markers are used as motion surrogates.

title: WE-EF-303-02: BEST IN PHYSICS (JOINT IMAGING- THERAPY): A Comprehensive Simulation of Image Guided Beam Gating for XXXX Treatments Using Scanned Proton Therapy.

answer: @entity1


abstract: INTRODUCTION: @entity3 ( @entity3 ) and @entity1 ( @entity1 ) both harbor multiple, T2-hyperintense white matter lesions on conventional magnetic resonance imaging (MRI).We aimed to determine the microstructural changes via @entity2 ( @entity2 ) in normal appearing thalami. We hypothesized that the apparent diffusion coefficient (ADC) values would be different in @entity3 and @entity1 , since the extent of arterial involvement is different in these two diseases. METHODS: @entity2 was performed for 50 @entity0 with @entity3 and 35 @entity0 with @entity1 along with gender- and age-matched controls whose conventional MRI revealed normal findings. @entity2 was done with 1.5 Tesla MR devices using echo planar imaging (EPI) for b   =   0, 1000  s/mm(2). ADC values were obtained from the thalami which appeared normal on T2-weighted and FLAIR images. Standard oval regions of interest (ROIs) of 0.5  cm(2) which were oriented parallel to the long axis of the thalamus were used for this purpose. RESULTS: The mean ADC value of the thalamus was (0.99        0.16)   *   10(-3)  mm(2)/s in @entity0 with @entity3 , whereas the mean ADC value was (0.78        0.06)   *   10(-3)  mm(2)/s in the control group. The mean ADC value was significantly higher in @entity0 with @entity3 compared to the controls (p   <   0.001). The mean ADC values of the thalamus were (0.78        0.08)   *   10(-3)  mm(2)/s in @entity1 @entity0 , and (0.75        0.08)   *   10(-3)  mm(2)/s in the control group, which are not significantly different (p   >   0.05). CONCLUSION: Our study revealed a difference in the diffusion of the thalami between @entity3 and @entity1 . @entity2 may aid in the radiological disease differentiation.

title: Role of thalamic diffusion for disease differentiation between XXXX and ischemic cerebral small vessel disease.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: @entity0 with @entity2 ( @entity2 ) are at high risk for @entity1 . Non-pharmacological interventions have attracted increasing interest for enhancing @entity2 @entity0 ' cognitive functions. METHODS: One-year follow-up data (T2 ) of a randomized controlled trial evaluating two 6-week cognitive trainings - a structured (NEUROvitalis, NV) and an unstructured (mentally fit, MF) program - compared with a waiting list control group (CG) in non-demented @entity2 @entity0 (Hoehn and Yahr I-III) are presented. Forty-seven @entity2 @entity0 were examined at T2 . Effects on overall cognitive functions (Mini-Mental State Examination and DemTect) were compared between all groups with repeated measurement analyses of variance. A combined score of the percentage change value from baseline (T0 ) to T2 was calculated to identify @entity0 who retained or improved their cognitive state (responders). The risk of developing @entity1 ( @entity1 ) was analyzed. RESULTS: Significant time * treatment effects on overall cognitive functions were found for both training groups, each compared separately to the CG (DemTect, P  <  0.05). Nine @entity0 (56.3%) of the NV group, seven (41.2%) of the MF group and three (21.4%) of the CG were responders. Comparing NV to CG the odds ratio was 4.7 [95% confidence interval (0.8; 33.3)], and comparing MF to CG it was 2.6 [95% confidence interval (0.4; 17.4)]. @entity1 risk for @entity0 without prior @entity1 was 40.0% in CG, 18.2% in MF and 18.2% in NV. The odds ratio was 3 comparing NV to CG, MF to CG. DISCUSSION: This study gives evidence that cognitive training may be effective to prevent @entity1 and onset of @entity1 in @entity2 @entity0 .

title: Cognitive training in XXXX reduces @entity1 in the long term.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: @entity0 with @entity2 ( @entity2 ) are at high risk for @entity1 . Non-pharmacological interventions have attracted increasing interest for enhancing @entity2 @entity0 ' cognitive functions. METHODS: One-year follow-up data (T2 ) of a randomized controlled trial evaluating two 6-week cognitive trainings - a structured (NEUROvitalis, NV) and an unstructured (mentally fit, MF) program - compared with a waiting list control group (CG) in non-demented @entity2 @entity0 (Hoehn and Yahr I-III) are presented. Forty-seven @entity2 @entity0 were examined at T2 . Effects on overall cognitive functions (Mini-Mental State Examination and DemTect) were compared between all groups with repeated measurement analyses of variance. A combined score of the percentage change value from baseline (T0 ) to T2 was calculated to identify @entity0 who retained or improved their cognitive state (responders). The risk of developing @entity1 ( @entity1 ) was analyzed. RESULTS: Significant time * treatment effects on overall cognitive functions were found for both training groups, each compared separately to the CG (DemTect, P  <  0.05). Nine @entity0 (56.3%) of the NV group, seven (41.2%) of the MF group and three (21.4%) of the CG were responders. Comparing NV to CG the odds ratio was 4.7 [95% confidence interval (0.8; 33.3)], and comparing MF to CG it was 2.6 [95% confidence interval (0.4; 17.4)]. @entity1 risk for @entity0 without prior @entity1 was 40.0% in CG, 18.2% in MF and 18.2% in NV. The odds ratio was 3 comparing NV to CG, MF to CG. DISCUSSION: This study gives evidence that cognitive training may be effective to prevent @entity1 and onset of @entity1 in @entity2 @entity0 .

title: Cognitive training in @entity2 reduces XXXX in the long term.

answer: @entity1


abstract: Between March 1984 and June 1993, linac radiosurgery was performed in 139 @entity0 for single brain @entity1 , using the non-invasive (Greitz-Bergstr  m) head fixation system. This atraumatic system was utilized for subsequent stereotactic CT/NMR staging to obtain strictly comparable neuro-imaging. Thus, @entity3 response was evaluated precisely and radiosurgery repeated (straight after the diagnostic sitting), as needed. No hospitalization or anaesthesia was necessary. The 25 mm target was the maximum size to avoid the risk of radiation induced reactions. In @entity1 exceeding this limit single doses were directed at more than one target at the same session. Focusing upon single or multiple targets was facilitated by 3-D stereotactic NMR. The results after one single sitting were compared with those obtained after staged sittings in the same @entity0 . Radiosurgery achieved disappearance or shrinkage of the @entity1 with resolution of the @entity2 and mid-line shift in 86% of the 139 @entity0 treated. In 47% of them, however, the success was the result of repeat radiosurgery and staged sittings. The non-invasive procedure is the keystone to optimize the radiosurgical results.

title: The results of radiosurgical management of 139 single cerebral XXXX .

answer: @entity1


abstract: OBJECTIVE. The purpose of this study was to compare 5-minute delayed transitional phase imaging using a 30   @entity3 angle (hereafter, 5min-FA30) and 20-minute hepatocyte phase imaging using a 10   @entity3 angle (hereafter, 20min-FA10) in gadoxetic acid-enhanced MRI for focal @entity2 detection and lesion-to-liver contrast-to-noise ratio (CNR), and to determine whether 5min-FA30 could replace 20min-FA10 with a 15-minute time saving. MATERIALS AND METHODS. One hundred sixteen @entity0 with 282 focal @entity2 (size range, 0.2-12.5 cm; malignant, n = 146; benign, n = 136) underwent @entity4 -enhanced MRI with 5min-FA30 and 20min-FA10 with a 3D T1-weighted gradient-echo sequence. Three radiologists independently assessed the presence of focal @entity2 using a 4-point scale, and detection sensitivity of focal @entity2 was calculated. Lesion-to-liver CNRs were calculated and compared in two image groups. RESULTS. There was no significant difference in detection sensitivity of focal @entity2 for all three readers between 5min-FA30 (mean, 95.4%) and 20min-FA10 (mean, 95.6%), irrespective of lesion size or @entity1 . The mean CNR on 5min-FA30 (167.9    84.1) was significantly higher than that on 20min-FA10 (160.2    79.5). However, the mean CNR difference between the two image groups was relatively small (7.8    41.9). CONCLUSION. Compared with 20min-FA10, 5min-FA30 provided higher CNR and similar sensitivity. These findings indicate that 5min-FA30 could replace 20-min delayed hepatocyte phase imaging using a 10   @entity3 angle with similar diagnostic performance and 15 minutes of time saving.

title: Feasibility of 5-Minute Delayed Transition Phase Imaging With 30   @entity3 Angle in Gadoxetic Acid-Enhanced 3D Gradient-Echo MRI of Liver, Compared With 20-Minute Delayed Hepatocyte Phase MRI With Standard 10   XXXX Angle.

answer: @entity3


abstract: OBJECTIVE. The purpose of this study was to compare 5-minute delayed transitional phase imaging using a 30   @entity3 angle (hereafter, 5min-FA30) and 20-minute hepatocyte phase imaging using a 10   @entity3 angle (hereafter, 20min-FA10) in gadoxetic acid-enhanced MRI for focal @entity2 detection and lesion-to-liver contrast-to-noise ratio (CNR), and to determine whether 5min-FA30 could replace 20min-FA10 with a 15-minute time saving. MATERIALS AND METHODS. One hundred sixteen @entity0 with 282 focal @entity2 (size range, 0.2-12.5 cm; malignant, n = 146; benign, n = 136) underwent @entity4 -enhanced MRI with 5min-FA30 and 20min-FA10 with a 3D T1-weighted gradient-echo sequence. Three radiologists independently assessed the presence of focal @entity2 using a 4-point scale, and detection sensitivity of focal @entity2 was calculated. Lesion-to-liver CNRs were calculated and compared in two image groups. RESULTS. There was no significant difference in detection sensitivity of focal @entity2 for all three readers between 5min-FA30 (mean, 95.4%) and 20min-FA10 (mean, 95.6%), irrespective of lesion size or @entity1 . The mean CNR on 5min-FA30 (167.9    84.1) was significantly higher than that on 20min-FA10 (160.2    79.5). However, the mean CNR difference between the two image groups was relatively small (7.8    41.9). CONCLUSION. Compared with 20min-FA10, 5min-FA30 provided higher CNR and similar sensitivity. These findings indicate that 5min-FA30 could replace 20-min delayed hepatocyte phase imaging using a 10   @entity3 angle with similar diagnostic performance and 15 minutes of time saving.

title: Feasibility of 5-Minute Delayed Transition Phase Imaging With 30   XXXX Angle in Gadoxetic Acid-Enhanced 3D Gradient-Echo MRI of Liver, Compared With 20-Minute Delayed Hepatocyte Phase MRI With Standard 10   @entity3 Angle.

answer: @entity3


abstract: UNASSIGNED: @entity4 serotype M1 is a frequent cause of severe @entity2 in @entity0 . Some M1 isolates are pathogenic in @entity1 and used in studies on @entity2 pathogenesis. We observed marked differences in @entity1 @entity2 caused by M1 strain SF370, 5448, 5448AP or @entity5 which prompted us to sequence the whole genome of isolates 5448 and @entity5 for comparative analysis. Strain 5448 is known to acquire inactivating mutations in the CovRS two-component system during @entity1 @entity2 , producing hypervirulent progeny such as 5448AP. Isolates @entity5 and 5448AP, more than 5448, caused disseminating @entity2 that became systemic and lethal. SF370 was not pathogenic. Phages caused gross genetic differences and increased the gene content of @entity5 by 8% as compared to 5448 and SF370. Each of six examined M1 genomes contained two CRISPR-Cas systems. Phage insertion destroyed a type II CRISPR-Cas system in @entity5 and other strains of serotypes M1, M3, M6 and M24, but not in M1 strains 5448, SF370, MGAS5005, A20 or M1 476. A resulting impaired defence against invading genetic elements could have led to the wealth of phages in @entity5 . @entity5 lacks genetic features of the MGAS5005-like clonal complex including the streptodornase that drives selection for hypervirulent clones with inactivated CovRS system. Still, inactivating mutations in covS were a common genetic feature of @entity5 and the MGAS5005-like isolate 5448AP. Abolished expression of the @entity3 proteinase SpeB, due to CovRS inactivation could be a common cause for hypervirulence of the two isolates. Moreover, an additional protein H-coding gene and a mutation in the regulator gene rofA distinguished @entity5 form other M1 isolates. In conclusion, hypervirulence of @entity4 M1 in @entity1 is not limited to the MGAS5005-like genotype.

title: Comparative Genomics of XXXX M1 isolates differing in virulence and propensity to cause @entity2 in @entity1 .

answer: @entity4


abstract: UNASSIGNED: @entity4 serotype M1 is a frequent cause of severe @entity2 in @entity0 . Some M1 isolates are pathogenic in @entity1 and used in studies on @entity2 pathogenesis. We observed marked differences in @entity1 @entity2 caused by M1 strain SF370, 5448, 5448AP or @entity5 which prompted us to sequence the whole genome of isolates 5448 and @entity5 for comparative analysis. Strain 5448 is known to acquire inactivating mutations in the CovRS two-component system during @entity1 @entity2 , producing hypervirulent progeny such as 5448AP. Isolates @entity5 and 5448AP, more than 5448, caused disseminating @entity2 that became systemic and lethal. SF370 was not pathogenic. Phages caused gross genetic differences and increased the gene content of @entity5 by 8% as compared to 5448 and SF370. Each of six examined M1 genomes contained two CRISPR-Cas systems. Phage insertion destroyed a type II CRISPR-Cas system in @entity5 and other strains of serotypes M1, M3, M6 and M24, but not in M1 strains 5448, SF370, MGAS5005, A20 or M1 476. A resulting impaired defence against invading genetic elements could have led to the wealth of phages in @entity5 . @entity5 lacks genetic features of the MGAS5005-like clonal complex including the streptodornase that drives selection for hypervirulent clones with inactivated CovRS system. Still, inactivating mutations in covS were a common genetic feature of @entity5 and the MGAS5005-like isolate 5448AP. Abolished expression of the @entity3 proteinase SpeB, due to CovRS inactivation could be a common cause for hypervirulence of the two isolates. Moreover, an additional protein H-coding gene and a mutation in the regulator gene rofA distinguished @entity5 form other M1 isolates. In conclusion, hypervirulence of @entity4 M1 in @entity1 is not limited to the MGAS5005-like genotype.

title: Comparative Genomics of @entity4 M1 isolates differing in virulence and propensity to cause XXXX in @entity1 .

answer: @entity2


abstract: UNASSIGNED: @entity4 serotype M1 is a frequent cause of severe @entity2 in @entity0 . Some M1 isolates are pathogenic in @entity1 and used in studies on @entity2 pathogenesis. We observed marked differences in @entity1 @entity2 caused by M1 strain SF370, 5448, 5448AP or @entity5 which prompted us to sequence the whole genome of isolates 5448 and @entity5 for comparative analysis. Strain 5448 is known to acquire inactivating mutations in the CovRS two-component system during @entity1 @entity2 , producing hypervirulent progeny such as 5448AP. Isolates @entity5 and 5448AP, more than 5448, caused disseminating @entity2 that became systemic and lethal. SF370 was not pathogenic. Phages caused gross genetic differences and increased the gene content of @entity5 by 8% as compared to 5448 and SF370. Each of six examined M1 genomes contained two CRISPR-Cas systems. Phage insertion destroyed a type II CRISPR-Cas system in @entity5 and other strains of serotypes M1, M3, M6 and M24, but not in M1 strains 5448, SF370, MGAS5005, A20 or M1 476. A resulting impaired defence against invading genetic elements could have led to the wealth of phages in @entity5 . @entity5 lacks genetic features of the MGAS5005-like clonal complex including the streptodornase that drives selection for hypervirulent clones with inactivated CovRS system. Still, inactivating mutations in covS were a common genetic feature of @entity5 and the MGAS5005-like isolate 5448AP. Abolished expression of the @entity3 proteinase SpeB, due to CovRS inactivation could be a common cause for hypervirulence of the two isolates. Moreover, an additional protein H-coding gene and a mutation in the regulator gene rofA distinguished @entity5 form other M1 isolates. In conclusion, hypervirulence of @entity4 M1 in @entity1 is not limited to the MGAS5005-like genotype.

title: Comparative Genomics of @entity4 M1 isolates differing in virulence and propensity to cause @entity2 in XXXX .

answer: @entity1


abstract: UNASSIGNED: Behavioral interventions to reduce @entity0 depend on strong health behavior theory. By identifying the psychosocial variables that lead causally to sexual risk, theories provide interventionists with a guide for how to change behavior. However, empirical research is critical to determining whether a particular theory adequately explains @entity0 . A large body of cross-sectional evidence, which has been reviewed elsewhere, supports the notion that certain theory-based constructs (e.g., self-efficacy) are correlates of @entity0 . However, given the limitations of inferring causality from correlational research, it is essential that we review the evidence from more methodologically rigorous studies (i.e., longitudinal and experimental designs). This systematic review identified 44 longitudinal studies in which investigators attempted to predict sexual risk from psychosocial variables over time. We also found 134 experimental studies (i.e., randomized controlled trials of @entity1 interventions), but of these only 9 (6.7  %) report the results of mediation analyses that might provide evidence for the validity of health behavior theories in predicting @entity0 . Results show little convergent support across both types of studies for most traditional, theoretical predictors of @entity0 . This suggests that the field must expand the body of empirical work that utilizes the most rigorous study designs to test our theoretical assumptions. The inconsistent results of existing research would indicate that current theoretical models of @entity0 are inadequate, and may require expansion or adaptation.

title: Do Behavioral Scientists Really Understand XXXX -Related Sexual Risk Behavior? A Systematic Review of Longitudinal and Experimental Studies Predicting Sexual Behavior.

answer: @entity1


abstract: OBJECTIVE. The purpose of this study was to retrospectively evaluate the relationship between periprostatic fat thickness on @entity1 using radical prostatectomy as the reference standard. MATERIALS AND METHODS. This study included 190 @entity0 (mean age [   SD], 66.9    7.0 years) who underwent MRI before radical prostatectomy. Two radiologists measured the subcutaneous and periprostatic fat thickness on midsagittal T2-weighted MR images as the shortest perpendicular distance from the pubic symphysis to the skin and prostate, respectively. Subcutaneous and periprostatic fat along with age, height, weight, body mass index, and @entity2 ( @entity2 ) were correlated with Gleason score by using Pearson (r) or Spearman (  ) correlation coefficients and compared between low- (Gleason score = 6) and high- (>=  7) grade @entity1 by using univariate and multivariate logistic regression analyses. RESULTS. The mean subcutaneous and periprostatic fat thicknesses were 24.0    8.4 mm and 5.0    2.0 mm, respectively. The Gleason score was significantly correlated with age (   = 0.181, p = 0.012), @entity2 (   = 0.345, p < 0.001), and periprostatic fat thickness (   = 0.228, p = 0.002). Multivariate analysis revealed that age, height, @entity2 level, and periprostatic fat thickness (odds ratio, 1.331; 95% CI, 1.063-1.666) were independently predictive of high-grade (p  <= 0.013) disease. CONCLUSION. Periprostatic fat thickness on MRI showed a mild to modest but significant correlation with @entity1 with radical prostatectomy as the reference standard and was an independent predictive factor for high-grade @entity1 .

title: Periprostatic Fat Thickness on MRI: Correlation With Gleason Score in XXXX .

answer: @entity1


abstract: PURPOSE: The purpose of this study was to determine if anaerobic performance as measured by the Wingate is decremented in elite female athletes when fraction of inspired @entity1 is decreased from 20.9% to 10%. METHOD: Nine collegiate female soccer players (Mweight  =  63.2      10  kg, Mheight  =  164      4.7  cm, Mage  =  18.6      0.5 year) performed 1 Wingate test under each condition separated by at least 24  hr. @entity1 consumption was measured breath by breath using a Sensor-Medics metabolic cart. Postexercise blood lactates were measured using the finger-stick method. During normoxic and @entity2 (10% inspired @entity1 [ @entity4 ]) conditions, @entity0 inhaled air from a 300-L weather balloon during the 30-s test. RESULTS: Peak power, minimum power, average power, postexercise blood @entity3 , preexercise and postexercise blood @entity4 saturation, and total @entity4 consumed during exercise and during recovery were not statistically different between conditions. However, the Fatigue Index and peak ventilation were significantly greater during @entity2 than normoxia (35      11% vs. 27      9% _ 91.6      14.2  L/min vs. 75.2      11.1  L/min, respectively, p  <  .05, Cohen's d  =  -  0.80 and -  1.29, respectively). Ventilation was elevated during @entity2 within 5  s of beginning the Wingate and remained elevated throughout exercise. This increased ventilation was sufficient to maintain @entity1 consumption during exercise. CONCLUSION: Under @entity2 conditions, the ventilatory response to the Wingate test is perhaps more important than aerobic capacity per se in determining whether or not Wingate performance is decremented.

title: Elite Female Athletes' Ventilatory Compensation to Decreased Inspired XXXX During the Wingate Test.

answer: @entity4


abstract: The association of @entity1 ( @entity1 ), @entity8 ( @entity8 ), @entity7 ( @entity7 ) and @entity6 (D) is known as @entity12 or @entity12 . Aside from these four cardinal features, a wide variety of @entity10 , urinary tract and endocrine glands have been described in this syndrome. In this report, the clinical features of six @entity0 with @entity12 are presented. All six @entity0 had @entity1 . Five of the six @entity0 had @entity8 , five @entity7 and five displayed abnormal audiogram findings. In addition, two had @entity11 , two delayed puberty, one @entity4 and one @entity5 with @entity3 attacks. Urinary tract dilatation was recorded in five @entity0 . Four @entity0 developed typical complications of @entity1 . One of them had overt @entity2 and @entity9 despite the short duration of @entity1 . In addition, this @entity0 had @entity1 , which is considered to be rare in this syndrome.

title: Various clinical aspects of XXXX .

answer: @entity12


abstract: INTRODUCTION: Peroral endoscopic myotomy (POEM) is an emerging treatment for @entity4 . @entity1 has been found in a significant number of @entity0 , but it is unknown whether subjective reports of reflux correlate with objective pH testing. The purpose of this study was to compare the objective rate of reflux with standardized reflux symptom scales after POEM. Our hypothesis was that subjective symptoms would not correlate with objective measurement of reflux. METHODS AND PROCEDURES: Data on all @entity0 undergoing POEM were collected prospectively between August 2012 and June 2014 and included demographics, objective testing (48-h pH probe, manometry, endoscopy), as well as @entity2 ( @entity2 ), GERD symptom scale (GERSS), and antacid use. RESULTS: Forty-three @entity0 underwent POEM during the study period. The mean age was 53.5      17.4  years with a BMI of 29.6      8.4  kg/m(2), and 27 (63%) were male. Forty-two @entity0 (98%) completed at least 6  months of follow-up, and 26 (60%) underwent repeat pH measurement. @entity3 scores improved from 4 (0-5) at baseline to 0 (0-3) (p  <  0.001). On follow-up pH testing, 11 (42%) were normal and 15 (58%) had elevated DeMeester scores. Postoperative GERSS or @entity2 scores did not correlate with DeMeester scores on Spearman's rank-order tests (r  =  0.02, p  =  0.93 and r  =  0.04, p  =  0.50, respectively). Postoperative PPI use was not significantly associated with normal or abnormal pH testing: 5 of 7 (71%) @entity0 who were taking PPIs postoperatively had abnormal DeMeester scores compared to 9 of 18 (50%) of @entity0 who were not taking PPIs (p  =  0.332). CONCLUSIONS: Peroral endoscopic myotomy provides excellent @entity3 relief for @entity0 with @entity4 , but is associated with a high rate of reflux on pH testing postoperatively. Subjective symptoms are not a reliable indicator of postoperative reflux. Routine pH testing should be considered in all @entity0 following POEM.

title: XXXX do not correlate with objective pH testing after peroral endoscopic myotomy.

answer: @entity2


abstract: UNASSIGNED: Despite the clinical relevance of nocebo effects, few studies have addressed their underlying neural mechanisms in clinically-relevant @entity1 models. We aimed to address the contribution of nocebo effects and their underlying neural circuitry to central @entity1 , as it may develop over repeated @entity1 experiences due to negative @entity1 -related expectations. Healthy volunteers received verbal suggestions of @entity1 sensitization (nocebo group, N=28) or neutral instructions (control group, N=16). fMRI was used to investigate changes in neural responses during cued @entity1 anticipation and @entity1 delivered in successive fMRI sessions. @entity1 intensity was rated trial-by-trial, and expected @entity1 intensity, state @entity0 and @entity3 were assessed prior to each session. Behavioral analyses demonstrated significantly greater increases in both expected and perceived @entity1 in the nocebo group. The fMRI analysis performed on nocebo-responders only (N=14) revealed that these behavioral changes were associated with increased activation within the secondary somatosensory cortex and amygdala during @entity1 and amygdala during @entity1 stimulation when compared to controls. A subsequent psycho-physiological interaction analysis of the @entity1 phase showed increased functional connectivity between the anterior insula, which was set-up as seed region based on group results, and midcingulate cortex as a function of negative expectations. These findings support that negative @entity1 -related expectations can play a crucial role in @entity1 amplification of @entity4 , which is mediated, at least in part, by a neural up-regulation of @entity1 and their connectivity. These findings may have implications for the pathophysiology and treatment of chronic @entity2 .

title: Neural underpinnings of nocebo hyperalgesia in XXXX : A fMRI study in healthy volunteers.

answer: @entity4


abstract: BACKGROUND/AIM: To investigate the variations in the recurrence patterns of @entity1 according to lymph node involvement. MATERIALS AND METHODS: We reviewed the medical records of 170 @entity0 who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007. RESULTS: Among the @entity0 in the study group, 115 did not have lymph node metastases, whereas 55 did. A total of 27 @entity0 developed recurrences. Twelve were in the lymph node-negative group, and 15 were in the lymph node-positive group. The recurrence rate was higher in lymph node-positive group (27.3% versus 10.4%, P = 0.011). The recurrence pattern was not affected by lymph node involvement. However, distant recurrence was more common in the lymph node-positive group (53.3% versus 25%, P = 0.137). Additionally, distant failure was observed only in the @entity0 in the lymph node-negative group who received adjuvant radiotherapy. In this group, 3 @entity0 who did not receive adjuvant radiotherapy developed recurrences only in the pelvic region. CONCLUSION: The presence of lymph node @entity1 does not affect the site of recurrence. However, distant recurrence was more frequent in the lymph node-positive group.

title: Does lymph node involvement affect the patterns of recurrence in XXXX ?

answer: @entity1


abstract: BACKGROUND/AIM: In the treatment of @entity1 , encouraging results have been achieved with surgical treatment, especially for @entity3 ( @entity3 ). Drug resistance must be diagnosed as early as possible, because the ensuing @entity2 can be eliminated surgically via temporal lobe surgery in a high percentage (70%-90%) of @entity0 . In this study we share our experience, in a single institution, of surgical treatment of intractable @entity3 . MATERIALS AND METHODS: Between March 2006 and November 2010 we performed 127 corticoamygdalohippocampectomy (CAH) procedures. All CAH surgical procedures were done as described by Niemeyer's technique. Resection lengths were 4-4.5 cm from the temporal pole. RESULTS: At the end of 24 months, 79.7% (n = 94) @entity0 were still on antiepileptic medications, with 55 of them on a decreased number or dose of drugs, and 20.3 (n = 24) patients were antiepileptic drug-free. Postoperative Engel's classes were 1, 2, and 3 in 87.2%, 5.08%, and 7.6%, respectively. There was no mortality in follow-up, and @entity4 in 1 @entity0 (0.84%) was the only morbidity. CONCLUSION: In our series we found that the outcome of surgery is associated with careful @entity0 selection, which requires a detailed investigation of the @entity0 . Our final conclusion is that outcome scores are independent of age, pathology, or sex but are dependent on correct @entity0 selection.

title: Surgery for intractable XXXX : experience of a single institution.

answer: @entity3


abstract: BACKGROUND: The practice of @entity0 and treatment in China varies to that in western developed countries. With the unavailability of radioactive tracer technique for @entity3 ( @entity3 ), using blue dye alone has been the only option in China. Also, the diagnosis of @entity0 in most Chinese centres heavily relies on intraoperative instant frozen histology which is normally followed by sentinel lymph nodes mapping, @entity3 and the potential breast and axillary operations in one consecutive session. This practice appears to cause a high false negative rate (FNR) for @entity3 . The present study aimed to investigate the impact of the current practice in China on the accuracy of @entity3 , and whether partial axillary lymph node dissection (PALND), dissection of lymph nodes @entity2 (ICBN), was a good complementary procedure following @entity3 using blue dye. METHODS: 289 @entity1 with clinically node-negative @entity0 were identified and recruited. Tumorectomy, intraoperative instant frozen histological diagnosis, @entity3 using @entity6 dye, and PALND or complete @entity4 ( @entity4 ) were performed in one consecutive operative session. The choice of @entity3 only, @entity3 followed by PALND or by @entity4 was based on the pre-determined protocol and preoperative choice by the @entity1 . Clinical parameters were analyzed and survival analysis was performed. RESULTS: 37  % @entity1 with clinically negative nodes were found nodes positive. 59 @entity1 with positive SLN underwent @entity4 , including 47 @entity1 with up to two positive nodes which were all located inferior to the ICBN. 9 @entity1 had failed @entity3 and underwent PALND. Among them, 3 (33.3  %) @entity1 were found to have one metastatic node. 149 @entity1 showed negative @entity3 but chose PALND. Among them, 30 (20.1  %), 14 (9.4) and 1 (0.7  %) @entity1 were found to have one, two and three metastatic node(s), respectively. PALND detected 48 (30.4  %) @entity1 who had either failed @entity3 or negative @entity3 to have additional positive nodes. All the @entity1 with up to two positive nodes had their nodes located inferior to the ICBN. The FNR of @entity3 was 43  %. The accuracy rate was 58  %. The follow-up ranged 12-33 months. The incidence of @entity5 for @entity3 , PALND, and @entity4 was 0  %, 0  %, and 25.4  %, respectively (P   <   0.005). The disease-free survivals for @entity3 , PALND, and @entity4 groups were 95.8  %, 96.8  %, and 94.9  %, respectively (p   >   0.05). CONCLUSIONS: Under the circumstances of current practice in China, PALND is a good complementary procedure following @entity3 in clinically node-negative @entity0 .

title: Partial axillary lymph node dissection inferior to the @entity2 complements sentinel node biopsy in @entity1 with clinically node-negative XXXX .

answer: @entity0


abstract: BACKGROUND: The practice of @entity0 and treatment in China varies to that in western developed countries. With the unavailability of radioactive tracer technique for @entity3 ( @entity3 ), using blue dye alone has been the only option in China. Also, the diagnosis of @entity0 in most Chinese centres heavily relies on intraoperative instant frozen histology which is normally followed by sentinel lymph nodes mapping, @entity3 and the potential breast and axillary operations in one consecutive session. This practice appears to cause a high false negative rate (FNR) for @entity3 . The present study aimed to investigate the impact of the current practice in China on the accuracy of @entity3 , and whether partial axillary lymph node dissection (PALND), dissection of lymph nodes @entity2 (ICBN), was a good complementary procedure following @entity3 using blue dye. METHODS: 289 @entity1 with clinically node-negative @entity0 were identified and recruited. Tumorectomy, intraoperative instant frozen histological diagnosis, @entity3 using @entity6 dye, and PALND or complete @entity4 ( @entity4 ) were performed in one consecutive operative session. The choice of @entity3 only, @entity3 followed by PALND or by @entity4 was based on the pre-determined protocol and preoperative choice by the @entity1 . Clinical parameters were analyzed and survival analysis was performed. RESULTS: 37  % @entity1 with clinically negative nodes were found nodes positive. 59 @entity1 with positive SLN underwent @entity4 , including 47 @entity1 with up to two positive nodes which were all located inferior to the ICBN. 9 @entity1 had failed @entity3 and underwent PALND. Among them, 3 (33.3  %) @entity1 were found to have one metastatic node. 149 @entity1 showed negative @entity3 but chose PALND. Among them, 30 (20.1  %), 14 (9.4) and 1 (0.7  %) @entity1 were found to have one, two and three metastatic node(s), respectively. PALND detected 48 (30.4  %) @entity1 who had either failed @entity3 or negative @entity3 to have additional positive nodes. All the @entity1 with up to two positive nodes had their nodes located inferior to the ICBN. The FNR of @entity3 was 43  %. The accuracy rate was 58  %. The follow-up ranged 12-33 months. The incidence of @entity5 for @entity3 , PALND, and @entity4 was 0  %, 0  %, and 25.4  %, respectively (P   <   0.005). The disease-free survivals for @entity3 , PALND, and @entity4 groups were 95.8  %, 96.8  %, and 94.9  %, respectively (p   >   0.05). CONCLUSIONS: Under the circumstances of current practice in China, PALND is a good complementary procedure following @entity3 in clinically node-negative @entity0 .

title: Partial axillary lymph node dissection inferior to the XXXX complements sentinel node biopsy in @entity1 with clinically node-negative @entity0 .

answer: @entity2


abstract: BACKGROUND: The practice of @entity0 and treatment in China varies to that in western developed countries. With the unavailability of radioactive tracer technique for @entity3 ( @entity3 ), using blue dye alone has been the only option in China. Also, the diagnosis of @entity0 in most Chinese centres heavily relies on intraoperative instant frozen histology which is normally followed by sentinel lymph nodes mapping, @entity3 and the potential breast and axillary operations in one consecutive session. This practice appears to cause a high false negative rate (FNR) for @entity3 . The present study aimed to investigate the impact of the current practice in China on the accuracy of @entity3 , and whether partial axillary lymph node dissection (PALND), dissection of lymph nodes @entity2 (ICBN), was a good complementary procedure following @entity3 using blue dye. METHODS: 289 @entity1 with clinically node-negative @entity0 were identified and recruited. Tumorectomy, intraoperative instant frozen histological diagnosis, @entity3 using @entity6 dye, and PALND or complete @entity4 ( @entity4 ) were performed in one consecutive operative session. The choice of @entity3 only, @entity3 followed by PALND or by @entity4 was based on the pre-determined protocol and preoperative choice by the @entity1 . Clinical parameters were analyzed and survival analysis was performed. RESULTS: 37  % @entity1 with clinically negative nodes were found nodes positive. 59 @entity1 with positive SLN underwent @entity4 , including 47 @entity1 with up to two positive nodes which were all located inferior to the ICBN. 9 @entity1 had failed @entity3 and underwent PALND. Among them, 3 (33.3  %) @entity1 were found to have one metastatic node. 149 @entity1 showed negative @entity3 but chose PALND. Among them, 30 (20.1  %), 14 (9.4) and 1 (0.7  %) @entity1 were found to have one, two and three metastatic node(s), respectively. PALND detected 48 (30.4  %) @entity1 who had either failed @entity3 or negative @entity3 to have additional positive nodes. All the @entity1 with up to two positive nodes had their nodes located inferior to the ICBN. The FNR of @entity3 was 43  %. The accuracy rate was 58  %. The follow-up ranged 12-33 months. The incidence of @entity5 for @entity3 , PALND, and @entity4 was 0  %, 0  %, and 25.4  %, respectively (P   <   0.005). The disease-free survivals for @entity3 , PALND, and @entity4 groups were 95.8  %, 96.8  %, and 94.9  %, respectively (p   >   0.05). CONCLUSIONS: Under the circumstances of current practice in China, PALND is a good complementary procedure following @entity3 in clinically node-negative @entity0 .

title: Partial axillary lymph node dissection inferior to the @entity2 complements sentinel node biopsy in XXXX with clinically node-negative @entity0 .

answer: @entity1


abstract: UNASSIGNED: We examined the sex difference concerning the coronary artery response between @entity5 and ER in this study. We already reported the difference of coronary response between @entity2 ( @entity5 ) and @entity6 (ER). We performed both @entity5 and ER tests of 461 @entity0 (male 294 @entity0 , female 167 @entity0 , mean age 64.4      11.3  years) during 23  years. Positive @entity4 was defined as >99  % transient luminal narrowing with usual @entity1 and/or ischemic ECG changes. Firstly, @entity5 was administered in incremental doses of 20/50/(80)   g into the RCA and 20/50/100/(200)   g into the LCA over 20  s. Secondly, ER was administered in a total dose of 40   g into the RCA and of 64   g into the LCA over 2-4  min. Intracoronary injection of @entity5 and ER provoked @entity3 in 221 @entity0 consisting of 160 male @entity0 and 61 female @entity0 . In female @entity0 , the @entity3 provoked by @entity5 was almost perfect except in two @entity0 (59 @entity0 , 96.7  %), while ER provoked @entity3 in only 20 @entity0 (32.8  %). In male @entity0 , provoked @entity3 by @entity5 (129 @entity0 , 80.6  %) was significantly higher than ER (97 @entity0 , 60.6  %). As a @entity3 provocation test, @entity5 is more sensitive than ER in both sexes and especially in females. We may select two pharmacological agents by sex differences to provoke @entity4 in the cardiac catheterization laboratory in the future.

title: Gender differences in sensitivity of @entity2 and @entity6 to XXXX provocation test.

answer: @entity4


abstract: UNASSIGNED: We examined the sex difference concerning the coronary artery response between @entity5 and ER in this study. We already reported the difference of coronary response between @entity2 ( @entity5 ) and @entity6 (ER). We performed both @entity5 and ER tests of 461 @entity0 (male 294 @entity0 , female 167 @entity0 , mean age 64.4      11.3  years) during 23  years. Positive @entity4 was defined as >99  % transient luminal narrowing with usual @entity1 and/or ischemic ECG changes. Firstly, @entity5 was administered in incremental doses of 20/50/(80)   g into the RCA and 20/50/100/(200)   g into the LCA over 20  s. Secondly, ER was administered in a total dose of 40   g into the RCA and of 64   g into the LCA over 2-4  min. Intracoronary injection of @entity5 and ER provoked @entity3 in 221 @entity0 consisting of 160 male @entity0 and 61 female @entity0 . In female @entity0 , the @entity3 provoked by @entity5 was almost perfect except in two @entity0 (59 @entity0 , 96.7  %), while ER provoked @entity3 in only 20 @entity0 (32.8  %). In male @entity0 , provoked @entity3 by @entity5 (129 @entity0 , 80.6  %) was significantly higher than ER (97 @entity0 , 60.6  %). As a @entity3 provocation test, @entity5 is more sensitive than ER in both sexes and especially in females. We may select two pharmacological agents by sex differences to provoke @entity4 in the cardiac catheterization laboratory in the future.

title: Gender differences in sensitivity of XXXX and @entity6 to @entity4 provocation test.

answer: @entity2


abstract: UNASSIGNED: We examined the sex difference concerning the coronary artery response between @entity5 and ER in this study. We already reported the difference of coronary response between @entity2 ( @entity5 ) and @entity6 (ER). We performed both @entity5 and ER tests of 461 @entity0 (male 294 @entity0 , female 167 @entity0 , mean age 64.4      11.3  years) during 23  years. Positive @entity4 was defined as >99  % transient luminal narrowing with usual @entity1 and/or ischemic ECG changes. Firstly, @entity5 was administered in incremental doses of 20/50/(80)   g into the RCA and 20/50/100/(200)   g into the LCA over 20  s. Secondly, ER was administered in a total dose of 40   g into the RCA and of 64   g into the LCA over 2-4  min. Intracoronary injection of @entity5 and ER provoked @entity3 in 221 @entity0 consisting of 160 male @entity0 and 61 female @entity0 . In female @entity0 , the @entity3 provoked by @entity5 was almost perfect except in two @entity0 (59 @entity0 , 96.7  %), while ER provoked @entity3 in only 20 @entity0 (32.8  %). In male @entity0 , provoked @entity3 by @entity5 (129 @entity0 , 80.6  %) was significantly higher than ER (97 @entity0 , 60.6  %). As a @entity3 provocation test, @entity5 is more sensitive than ER in both sexes and especially in females. We may select two pharmacological agents by sex differences to provoke @entity4 in the cardiac catheterization laboratory in the future.

title: Gender differences in sensitivity of @entity2 and XXXX to @entity4 provocation test.

answer: @entity6


abstract: BACKGROUND: This article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in @entity1 ( @entity1 ) randomized, controlled trial. METHODS: This study was a prospective, parallel-group, single-center trial. Fifty-one nondemented @entity0 with mild-to-moderate @entity1 were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resistance Exercise Training (PRET) and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention (BTA). RESULTS: Eighteen @entity0 in mFC and 20 @entity0 in PRET completed the trial. At 12 and at 24 months, no differences between groups were observed. At 12 months, relative to baseline, mFC improved on the Digit Span (estimated change: 0.3; interquartile range: 0, 0.7; P   =   0.04) and Stroop (0.3; 0, 0.6; P   =   0.04), and PRET improved only on the Digit Span (0.7; 0.3, 1; P   <   0.01). At 24 months, relative to baseline, mFC improved on the Digit Span (0.7; 0.3, 1.7; P   <   0.01) and Stroop (0.3; 0.1, 0.5; P   =   0.03), whereas PRET improved on the Digit Span (0.5; 0.2, 0.8; P   <   0.01), Stroop (0.2; -0.1, 0.6; P   =   0.048), and BTA (0.3; 0, 0.8; P   =   0.048). No neurological or cognitive adverse events were observed. CONCLUSIONS: This study provides class IV level of evidence that 24 months of PRET or mFC may improve @entity3 in nondemented @entity0 with mild-to-moderate @entity1 .    2015 International Parkinson and @entity2 Society.

title: Exercise improves cognition in XXXX : The PRET- @entity1 randomized, clinical trial.

answer: @entity1


abstract: BACKGROUND: This article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in @entity1 ( @entity1 ) randomized, controlled trial. METHODS: This study was a prospective, parallel-group, single-center trial. Fifty-one nondemented @entity0 with mild-to-moderate @entity1 were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resistance Exercise Training (PRET) and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention (BTA). RESULTS: Eighteen @entity0 in mFC and 20 @entity0 in PRET completed the trial. At 12 and at 24 months, no differences between groups were observed. At 12 months, relative to baseline, mFC improved on the Digit Span (estimated change: 0.3; interquartile range: 0, 0.7; P   =   0.04) and Stroop (0.3; 0, 0.6; P   =   0.04), and PRET improved only on the Digit Span (0.7; 0.3, 1; P   <   0.01). At 24 months, relative to baseline, mFC improved on the Digit Span (0.7; 0.3, 1.7; P   <   0.01) and Stroop (0.3; 0.1, 0.5; P   =   0.03), whereas PRET improved on the Digit Span (0.5; 0.2, 0.8; P   <   0.01), Stroop (0.2; -0.1, 0.6; P   =   0.048), and BTA (0.3; 0, 0.8; P   =   0.048). No neurological or cognitive adverse events were observed. CONCLUSIONS: This study provides class IV level of evidence that 24 months of PRET or mFC may improve @entity3 in nondemented @entity0 with mild-to-moderate @entity1 .    2015 International Parkinson and @entity2 Society.

title: Exercise improves cognition in @entity1 : The PRET- XXXX randomized, clinical trial.

answer: @entity1


abstract: BACKGROUND: Wireless pH-monitoring is an accurate method for diagnosing adults with @entity1 ( @entity1 ). The aim of this study was to evaluate the use of the Bravo capsule on @entity0 investigated for @entity1 in terms of safety, tolerability and feasibility before and after administration of proton pump inhibitors. METHODS: A Bravo capsule was inserted during upper endoscopy under general anaesthesia or deep sedation with @entity2 . 48-hour pH-metry was performed in 106 @entity0 (50 males, 56 females) at the median age of 11  years (range 17  months-18  years). On the second day of investigation, proton pump inhibitor (PPI) was given at a mean dose of 1.6  mg/kg (SD   0.6  mg). The definition of @entity1 was set to a reflux index (RI) of >= 5% and DeMeester score (DMS) >= 14.7. RESULTS: Application of the capsule was successful in 103 of the 106 @entity0 (97.2%) and interpretable in 99 of these 103 (96.1%). 49 of the @entity0 with interpretable results (49.5%) had @entity1 according to RI, while 51 (56.7%) had @entity1 according to DMS. After PPI was given on day 2, RI decreased from a median of 4.9% (range 0.3-63.4%) to 2.2% (0-58.0%), while DMS decreased from a median of 17.6 (range 2.2-207.6) to 8.2 (0.3-178.6), respectively (p <   0.0001). No severe adverse events were reported. CONCLUSION: Wireless pH-metry is a safe and tolerable method when investigating @entity0 for @entity1 . PPI given on the second day of assessment provides additional information on response to treatment suggesting that pH-metry preferably should be extended to 48  hours.

title: Clinical value of wireless pH-monitoring of gastro-esophageal reflux in XXXX before and after proton pump inhibitors.

answer: @entity0


abstract: AIMS: Systolic pulmonary artery pressure (sPAP) is a well-known outcome predictor in @entity0 with @entity4 . Limited data are available regarding the evaluation of right ventricular (RV) performance, particularly in @entity0 with @entity6 ( @entity6 ). The aim of this study was to evaluate the prevalence, determinants, and prognostic significance of @entity2 in severe @entity6 independently from the strategy of treatment chosen. METHODS AND RESULTS: Two hundred @entity0 (mean age: 79.9    8.8 years) with severe @entity6 underwent two-dimensional and speckle tracking echocardiography for the evaluation of left ventricular (LV) and RV functions, aortic valve gradients, and sPAP. A @entity3 ( @entity3 )  <=17 mm defined @entity2 . @entity2 was detected in 48 @entity0 (24%). At multivariable regression analysis, @entity7 (r = -0.29, P = 0.001), mean aortic gradient (r = 0.25, P = 0.002), and LV ejection fraction (r = 0.18, P = 0.02) were well correlated with @entity3 . After a median 16-month follow-up, @entity1 occurred in 17 @entity0 . At multivariate Cox regression analysis, @entity5 ( @entity3  <=17 mm and LVEF  <=50%) emerged as the strongest predictor of prognosis (hazard ratio 4.08, 95% confidence interval 1.36-12.22; P = 0.012). CONCLUSIONS: @entity2 is common in @entity6 @entity0 , and this finding can likely be accounted for by the RV-LV interdependence. Given that biventricular function impairment was a strong predictor of mortality in our population, we suggest that @entity2 should be systematically looked for in @entity6 @entity0 .

title: Prevalence and prognostic value of right XXXX in severe @entity6 .

answer: @entity2


abstract: AIMS: Systolic pulmonary artery pressure (sPAP) is a well-known outcome predictor in @entity0 with @entity4 . Limited data are available regarding the evaluation of right ventricular (RV) performance, particularly in @entity0 with @entity6 ( @entity6 ). The aim of this study was to evaluate the prevalence, determinants, and prognostic significance of @entity2 in severe @entity6 independently from the strategy of treatment chosen. METHODS AND RESULTS: Two hundred @entity0 (mean age: 79.9    8.8 years) with severe @entity6 underwent two-dimensional and speckle tracking echocardiography for the evaluation of left ventricular (LV) and RV functions, aortic valve gradients, and sPAP. A @entity3 ( @entity3 )  <=17 mm defined @entity2 . @entity2 was detected in 48 @entity0 (24%). At multivariable regression analysis, @entity7 (r = -0.29, P = 0.001), mean aortic gradient (r = 0.25, P = 0.002), and LV ejection fraction (r = 0.18, P = 0.02) were well correlated with @entity3 . After a median 16-month follow-up, @entity1 occurred in 17 @entity0 . At multivariate Cox regression analysis, @entity5 ( @entity3  <=17 mm and LVEF  <=50%) emerged as the strongest predictor of prognosis (hazard ratio 4.08, 95% confidence interval 1.36-12.22; P = 0.012). CONCLUSIONS: @entity2 is common in @entity6 @entity0 , and this finding can likely be accounted for by the RV-LV interdependence. Given that biventricular function impairment was a strong predictor of mortality in our population, we suggest that @entity2 should be systematically looked for in @entity6 @entity0 .

title: Prevalence and prognostic value of right @entity2 in severe XXXX .

answer: @entity6


abstract: PURPOSE/OBJECTIVES: To examine differences in healthcare service utilization among @entity0 with @entity1 participating in a nurse-led psychoeducational intervention.   . DESIGN: Secondary analysis of trial data.   . SETTING: Four Michigan @entity1 centers.    . SAMPLE: 484 @entity0 with @entity1 .    . METHODS: @entity0 were randomized to three groups. MAIN RESEARCH VARIABLES: Study arm (brief, extensive, or control), @entity3 visitation (one or more times versus none), inpatient hospitalizations (one or more times versus none), and covariates.   . FINDINGS: No significant differences in @entity3 or inpatient hospitalizations were observed among study arms. @entity3 were more frequent for @entity0 with lung or @entity2 , more comorbidities, and lower baseline QOL. Baseline QOL was associated with inpatient hospitalizations in the adjusted analysis.   . CONCLUSIONS: The psychoeducational intervention, either in brief or extensive format, is unlikely to increase healthcare service utilization.   . IMPLICATIONS FOR NURSING: Efficacious nurse-led psychoeducational interventions to improve QOL do not place undue burdens on the healthcare system and may improve care.   .

title: Effect of a Nurse-Led Psychoeducational Intervention on Healthcare Service Utilization Among Adults    With XXXX .

answer: @entity1


abstract: Importance: The Society for Vascular Surgery recommends annual surveillance with computed tomography (CT) or ultrasonography after endovascular @entity3 repair (EVAR) for @entity4 . However, such lifelong surveillance may be unnecessary for most @entity0 , thereby contributing to overuse of imaging services. Objective: To investigate whether nonadherence to Society for Vascular Surgery-recommended surveillance guidelines worsens long-term outcomes after EVAR among Medicare beneficiaries. Design, Setting, and @entity0 : We collected data from Medicare claims from January 1, 2002, through December 31, 2011. A total of 9503 @entity0 covered by fee-for-service Medicare who underwent EVAR from January 1, 2002, through December 31, 2005, were categorized as receiving complete or incomplete surveillance. We performed logistic regressions controlling for @entity0 demographic and hospital characteristics. @entity0 were then matched by propensity score with adjusting for all demographic variables, including age, sex, race, Medicaid eligibility, residential status, hospital volume, @entity5 , and all preexisting comorbidities. We then calculated differences in long-term outcomes after EVAR between adjusted groups. Data analysis was performed from January 1, 2002, through December 31, 2011. Main Outcomes and Measures: Post-EVAR imaging modality, @entity2 -related mortality, late @entity1 , and complications. Results: Median follow-up duration was 6.1 years. Incomplete surveillance was observed in 5526 of 9695 @entity0 (57.0%) who survived the initial hospital stay at a mean (SD) of 5.2 (2.9) years after EVAR. After propensity matching, our cohort consisted of 7888 @entity0 , among whom 3944 (50.0%) had incomplete surveillance. For those in the matched cohort, @entity0 with incomplete surveillance had a lower incidence of late @entity1 (26 of 3944 [0.7%] vs 57 of 3944 [1.4%]; P   =   .001) and major or minor reinterventions (46 of 3944 [1.2%] vs 246 of 3944 [6.2%]; P   <   .001) in unadjusted analysis. Aneurysm-related mortality was not statistically different between groups (13 of 3944 [0.3%] vs 24 of 3944 [0.6%]; P   =   .07). In adjusted analysis of postoperative outcomes controlling for all @entity0 and hospital factors by the tenth postoperative year, @entity0 in the incomplete surveillance group experienced lower rates of total complications (2.1% vs 14.0%; P   <   .001), late @entity1 (1.1% vs 5.3%; P   <   .001), major or minor reinterventions (1.4% vs 10.0%; P   <   .001), @entity2 -related mortality (0.4% vs 1.3%; P   <   .001), and all-cause mortality (30.9% vs 68.8%, P   <   .001). Conclusions and Relevance: Nonadherence to the Society for Vascular Surgery guidelines for post-EVAR imaging was not associated with poor outcomes, suggesting that, in many @entity0 , less frequent surveillance is not associated with worse outcomes. Improved criteria for defining optimal surveillance will achieve higher value in @entity2 care.

title: Postoperative Surveillance and Long-term Outcomes After XXXX Repair Among Medicare Beneficiaries.

answer: @entity2


abstract: UNASSIGNED: In a pursuit to develop a commercially exploitable and traceable gene delivery vehicle, here, we develop next generation @entity4 nanoparticle-DNA complex (CNPLex). CNPLexes were used to transfect green fluorescent protein (GFP) reporter gene containing plasmid DNA (pDNA) pEGFP-N1 targeting @entity0 cells MCF-7 and MDA-MB231. Prepared CNPs were optimized for particle size, surface potential, polymer surface decoration, absorbance efficiency, fluorescence efficiency, IR spectroscopic signatures, and DNA loading and release efficiencies. Rigorous biophysical methods were employed to determine the variations in physicochemical properties of CNPs after surface decoration with polymers followed by complexation with pDNA. Optimized CNPLexes were used to deliver pEGFP-N1 plasmid and efficiency of GFP was followed by fluorescence microscopy and quantified by flow assisted cell sorting. @entity3 was used as positive control according to manufacturer's protocol and found to be comparative in transfection efficiency with one of our novel formulations. Further evaluation of cell @entity2 and cell viability was performed by LDH activity and @entity1 assay, respectively. It was found that cell @entity2 furnished by polymer decorated @entity4 nanoparticles was significantly low compared to the parent polymer ( @entity6 , @entity5 ). Similarly cell viability was found to be much higher with CNPLexes compared to @entity5 alone. This established the developed particles as better transfecting agents for reporter gene plasmid pEGFP-N1 compared to @entity5 and showed similar efficacy to one of the best known commercial transfection agents Liofectamine2000 in @entity0 cells MCF-7 and MDA-MB231.

title: Next Generation XXXX Nanoparticles for Efficient Gene Therapy.

answer: @entity4


abstract: PURPOSE: To illustrate that @entity1 may be the basis for refractory @entity5 after laser-assisted in situ keratomileusis (LASIK). METHODS: The methodology used is that of a retrospective medical record review of a small case series. RESULTS: Three male @entity0 , aged 30 to 48 years, referred in 2012 for @entity5 refractory to treatment within 1 year of LASIK or LASIK enhancement are reported. Each @entity0 gave history of @entity6 , light sensitivity, and difficulty with visual activities beginning within 2 months of LASIK or LASIK enhancement. Best-corrected visual acuity was 20/15 or 20/20 in each of the six eyes. Tear-centered models and metrics did not explain persistent symptoms, which was consistent with inadequate response to standard @entity5 treatments used before referral and reported here. In vivo confocal microscopy was abnormal at presentation in each case and was followed over time. Treatments undertaken subsequent to referral included autologous serum tears (three cases), PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem) treatment (two cases), and systemic agents for @entity3 , @entity2 , or @entity4 (three cases). By the end of 2013, at a mean of 23 months after LASIK or LASIK enhancement, symptoms improved in all three @entity0 . CONCLUSIONS: @entity0 with persistent @entity5 out of proportion to clinical signs after LASIK have a syndrome that may best be classified as @entity1 . In vivo confocal microscopy can be informative as to the neuropathic basis of this condition. In keeping with current understanding of complex regional @entity3 , early multimodal treatment directed toward reducing peripheral nociceptive signaling is warranted to avoid subsequent centralization and persistence of @entity3 . Distinguishing this syndrome from typical post-LASIK @entity5 remains a challenge.

title: XXXX after LASIK.

answer: @entity1


abstract: UNASSIGNED: Elevating the yield and altering the composition of seed @entity2 (Toc's) are important to rapeseed breeding and production. However, little is known about the biosynthesis of Toc's in response to environmental signals. In this study, we investigated the effects of exogenous @entity3 (GA3) and @entity4 (PAC) on Toc biosynthesis. We also explored the interactive effects between the two plant growth regulators (PGRs) and other factors, such as PGR treatment duration, genotype, and growing location on the total Toc yield and composition in @entity1 seed. GA3 significantly enhanced the production of Toc's and elevated the a-/y-Toc ratio in a time- and genotype-dependent manner. By contrast, PAC significantly reduced Toc yield. Genotypic differences were observed in the effects of GA3 on Toc yield and composition in the seeds. GA3 significantly increased the Toc yield and a-/y-Toc ratio in Zheyou-50, a genotype with a low proportion of very long chain @entity0 (VLCFAs). However, GA3 did not significantly influence these parameters in Jiu-Er-13Xi, a genotype with a high VLCFA proportion. The increased Toc yield induced by GA3 was mediated by the upregulation of genes ( @entity5 and BnVTE1) that catalyze the production of Toc precursors. Therefore, applying GA3 can improve rapeseed quality by increasing Toc yield and improving Toc composition.

title: Effect of XXXX on the Biosynthesis of @entity2 in @entity1 ( @entity1 .) and Arabidopsis.

answer: @entity3


abstract: UNASSIGNED: Elevating the yield and altering the composition of seed @entity2 (Toc's) are important to rapeseed breeding and production. However, little is known about the biosynthesis of Toc's in response to environmental signals. In this study, we investigated the effects of exogenous @entity3 (GA3) and @entity4 (PAC) on Toc biosynthesis. We also explored the interactive effects between the two plant growth regulators (PGRs) and other factors, such as PGR treatment duration, genotype, and growing location on the total Toc yield and composition in @entity1 seed. GA3 significantly enhanced the production of Toc's and elevated the a-/y-Toc ratio in a time- and genotype-dependent manner. By contrast, PAC significantly reduced Toc yield. Genotypic differences were observed in the effects of GA3 on Toc yield and composition in the seeds. GA3 significantly increased the Toc yield and a-/y-Toc ratio in Zheyou-50, a genotype with a low proportion of very long chain @entity0 (VLCFAs). However, GA3 did not significantly influence these parameters in Jiu-Er-13Xi, a genotype with a high VLCFA proportion. The increased Toc yield induced by GA3 was mediated by the upregulation of genes ( @entity5 and BnVTE1) that catalyze the production of Toc precursors. Therefore, applying GA3 can improve rapeseed quality by increasing Toc yield and improving Toc composition.

title: Effect of @entity3 on the Biosynthesis of @entity2 in XXXX ( @entity1 .) and Arabidopsis.

answer: @entity1


abstract: UNASSIGNED: Elevating the yield and altering the composition of seed @entity2 (Toc's) are important to rapeseed breeding and production. However, little is known about the biosynthesis of Toc's in response to environmental signals. In this study, we investigated the effects of exogenous @entity3 (GA3) and @entity4 (PAC) on Toc biosynthesis. We also explored the interactive effects between the two plant growth regulators (PGRs) and other factors, such as PGR treatment duration, genotype, and growing location on the total Toc yield and composition in @entity1 seed. GA3 significantly enhanced the production of Toc's and elevated the a-/y-Toc ratio in a time- and genotype-dependent manner. By contrast, PAC significantly reduced Toc yield. Genotypic differences were observed in the effects of GA3 on Toc yield and composition in the seeds. GA3 significantly increased the Toc yield and a-/y-Toc ratio in Zheyou-50, a genotype with a low proportion of very long chain @entity0 (VLCFAs). However, GA3 did not significantly influence these parameters in Jiu-Er-13Xi, a genotype with a high VLCFA proportion. The increased Toc yield induced by GA3 was mediated by the upregulation of genes ( @entity5 and BnVTE1) that catalyze the production of Toc precursors. Therefore, applying GA3 can improve rapeseed quality by increasing Toc yield and improving Toc composition.

title: Effect of @entity3 on the Biosynthesis of @entity2 in @entity1 ( XXXX .) and Arabidopsis.

answer: @entity1


abstract: UNASSIGNED: Elevating the yield and altering the composition of seed @entity2 (Toc's) are important to rapeseed breeding and production. However, little is known about the biosynthesis of Toc's in response to environmental signals. In this study, we investigated the effects of exogenous @entity3 (GA3) and @entity4 (PAC) on Toc biosynthesis. We also explored the interactive effects between the two plant growth regulators (PGRs) and other factors, such as PGR treatment duration, genotype, and growing location on the total Toc yield and composition in @entity1 seed. GA3 significantly enhanced the production of Toc's and elevated the a-/y-Toc ratio in a time- and genotype-dependent manner. By contrast, PAC significantly reduced Toc yield. Genotypic differences were observed in the effects of GA3 on Toc yield and composition in the seeds. GA3 significantly increased the Toc yield and a-/y-Toc ratio in Zheyou-50, a genotype with a low proportion of very long chain @entity0 (VLCFAs). However, GA3 did not significantly influence these parameters in Jiu-Er-13Xi, a genotype with a high VLCFA proportion. The increased Toc yield induced by GA3 was mediated by the upregulation of genes ( @entity5 and BnVTE1) that catalyze the production of Toc precursors. Therefore, applying GA3 can improve rapeseed quality by increasing Toc yield and improving Toc composition.

title: Effect of @entity3 on the Biosynthesis of XXXX in @entity1 ( @entity1 .) and Arabidopsis.

answer: @entity2


abstract: In this study, an alternative use of @entity4 (SEV, a cross-linked @entity5 which is a widely known pharmaceutical compound) was suggested. The existence of primary and secondary @entity0 groups (with different ratios) in its molecule increases its adsorption potential and use as biosorbent material. SEV was tested as biosorbent material aiming the removal of heavy metals and dyes from simulated effluents. As heavy metals and dyes, @entity3 ( @entity3 ) and @entity2 ( @entity2 ) were used, respectively. A full adsorption study was done confirming the strong adsorption capability of SEV. The maximum theoretical adsorption capacity (Qm) was 772 and 485mg/g for single-component solutions of @entity2 and @entity3 , respectively; the respective values for binary mixtures of the same concentration (200mg/L) were 445 and 309mg/g respectively (calculated after fitting to Langmuir-Freundlich isotherm model at 25  C). The same experiments were also done at increasing temperatures (45 and 65  C) concluding thermodynamic remarks (  H(0)>0;   G(0)<0;   S(0)>0). The effect of contact time was analyzed running kinetic adsorption experiments and fitting them to pseudo-second order kinetic equation. The reusability was evaluated completing successfully 20 cycles of reuse (adsorption/desorption). The adsorption mechanism among SEV molecules and @entity3 or/and @entity2 was clarified using FTIR spectroscopy before and after adsorption in line with a detailed theoretical modeling which provided important calculations. SEV was also characterized using swelling experiments, @entity1 , SEM, XRD, TGA techniques.

title: Alternative use of cross-linked XXXX (known as Sevelamer pharmaceutical compound) as biosorbent.

answer: @entity5


abstract: OBJECTIVE: Participation in cardiac rehabilitation (CR) after hospitalisation for @entity1 ( @entity1 ) is estimated to below, but specific data for Belgium are lacking. Therefore, we wanted to evaluate attendance after @entity1 hospitalisation compared to @entity0 after cardiac surgery or @entity3 ( @entity3 ). Moreover, the improvement in exercise capacity was compared with the other @entity0 groups. METHODS AND RESULTS: @entity0 who were hospitalized for @entity1 (n=428), cardiac surgery (n=358) or @entity3 (n=467) in a single hospital, were prospectively included between January 2010 and May 2012. After hospitalisation for @entity1 only 9% participated, compared to 29% after @entity3 and 56% after cardiac surgery. Non- @entity0 in @entity1 were older, more frequently @entity0 (P <0.01) and had a better left ventricular ejection fraction (P < 0.05). In addition, they had more frequently @entity2 and problems to walk independently (P <0.01). At the start of the CR, @entity1 @entity0 had a worse clinical status and exercise capacity than @entity0 after cardiac surgery or @entity3 (all P <0.001). However, exercise training resulted in a significant improvement in each group separately (all P < 0.001) and the relative improvement in exercise capacity in @entity1 was comparable with the other groups. CONCLUSIONS: Only 9% of @entity1 @entity0 participated in CR after hospitalisation. Age, female gender, a relatively well-preserved ventricular function and @entity2 seem to impede attendance to CR. However, @entity1 @entity0 can have as much improvement in exercise capacity as other @entity0 populations, suggesting that more effort is needed to increase participation in CR among @entity1 @entity0 .

title: Participation in cardiac rehabilitation after hospitalisation for XXXX : a report from the BIO- @entity1 registry.

answer: @entity1


abstract: OBJECTIVE: Participation in cardiac rehabilitation (CR) after hospitalisation for @entity1 ( @entity1 ) is estimated to below, but specific data for Belgium are lacking. Therefore, we wanted to evaluate attendance after @entity1 hospitalisation compared to @entity0 after cardiac surgery or @entity3 ( @entity3 ). Moreover, the improvement in exercise capacity was compared with the other @entity0 groups. METHODS AND RESULTS: @entity0 who were hospitalized for @entity1 (n=428), cardiac surgery (n=358) or @entity3 (n=467) in a single hospital, were prospectively included between January 2010 and May 2012. After hospitalisation for @entity1 only 9% participated, compared to 29% after @entity3 and 56% after cardiac surgery. Non- @entity0 in @entity1 were older, more frequently @entity0 (P <0.01) and had a better left ventricular ejection fraction (P < 0.05). In addition, they had more frequently @entity2 and problems to walk independently (P <0.01). At the start of the CR, @entity1 @entity0 had a worse clinical status and exercise capacity than @entity0 after cardiac surgery or @entity3 (all P <0.001). However, exercise training resulted in a significant improvement in each group separately (all P < 0.001) and the relative improvement in exercise capacity in @entity1 was comparable with the other groups. CONCLUSIONS: Only 9% of @entity1 @entity0 participated in CR after hospitalisation. Age, female gender, a relatively well-preserved ventricular function and @entity2 seem to impede attendance to CR. However, @entity1 @entity0 can have as much improvement in exercise capacity as other @entity0 populations, suggesting that more effort is needed to increase participation in CR among @entity1 @entity0 .

title: Participation in cardiac rehabilitation after hospitalisation for @entity1 : a report from the BIO- XXXX registry.

answer: @entity1