abstract: A retrospective analysis of peripheral and renal vein plasma @entity5 activity has been performed in 9 @entity0 with @entity8 (3 fibromuscular @entity6 and 7 @entity3 ). In all cases angiography showed a reduction of the arterial diameter of more than 70 p. 100. The renal artery was occluded in 3 cases. All @entity0 received a constant @entity7 diet (100 mEq/day). Peripheral PRA values were classified as normal or low in 6 cases (less than 2.8 ng/ml/h) and high in one case (greater than 2.8 ng/ml/h): this values concerned 2 cases with @entity1 and 1 case with a narrowing of 90 p. 100. Renal venous @entity5 ratio of 1.5 or more has been found in 8 cases. In one case, the @entity4 was quite symmetrical (70 p. 100) and the ratio less than 1.5. The secretion index has been calculated as the ratio between the venoarterial difference of both affected and unaffected side over the arterial value of PRA (V-A/A). On the more stenosed side, was found a V-A/A ratio of 0.5 or more. This ratio is particularly high in case of artery @entity2 , but there is no correlation between the ratio and the degree of @entity4 . On the contralateral side, where the lesions were less important, the V-A/A ratio was low, ranging from 0 to 0.2; this estimation of @entity5 secretion was found despite a significant @entity4 on the angiography. 7 @entity0 underwent PTA or surgery. 2 kidneys with arterial @entity2 were nephrectomized. In 5 cases the surgical treatment is performed on the 2 sides during the same procedure.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Lateralization of @entity5 secretion in renovascular hypertension with bilateral XXXX ].

answer: @entity8


abstract: OBJECTIVE: To evaluate the prophylactic effect of @entity12 150 mg twice daily in @entity0 requiring one of the following non-steroidal anti-inflammatory drugs: @entity6 , @entity11 , @entity10 , and @entity9 . In addition, risk factors were studied in order to help in targeting of such treatment to specific groups of @entity0 . DESIGN: Double blind, placebo controlled, randomised, parallel group with endoscopic assessments at 0, 4, and 8 weeks. SETTING: Multicentre outpatient study at secondary referral centres in five European countries. @entity0 --297 @entity0 with @entity2 or @entity3 over the age of 18 without lesions in the stomach and duodenum at baseline endoscopy (after one week without taking non-steroidal anti-inflammatory drugs). Those taking other antirheumatic agents, concomitant ulcerogenic drugs, or treatment for peptic ulcers within the previous 30 days were excluded. Age, sex, @entity1 , and type of non-steroidal anti-inflammatory drug used were comparable in the two treatment groups. In all, 263 @entity0 completed the trial. INTERVENTIONS: @entity12 150 mg twice daily or placebo (plus the selected non-steroidal anti-inflammatory drug) was prescribed within five days after the baseline endoscopy for two consecutive periods of four weeks. @entity5 was permitted during the study, but not antacids. @entity0 were withdrawn if the most severe grade of damage (including ulceration) was found at the four week endoscopy or when indicated, or with lesser damage at the investigator's discretion. END POINT: Frequency of @entity8 , or both. MEASUREMENTS AND MAIN RESULTS: The cumulative incidence of peptic ulceration by eight weeks was 10.3% (27/263); 2 out of 135 (1.5%) developed duodenal ulceration in the @entity12 group, compared with 10 out of 126 (8%) taking placebo. The frequency of gastric ulceration was the same (6%) for the two groups at eight weeks. Though significantly fewer @entity7 developed in the @entity12 group by eight weeks. The frequency of non-ulcerative lesions in the duodenum did not differ greatly for the two groups at either time point. Twelve out of 75 (16%) @entity0 taking piroxicam developed peptic ulceration, of whom two thirds had duodenal ulceration. @entity0 with a history of peptic @entity4 were particularly susceptible to recurrent ulceration, against which @entity12 offered some protection. CONCLUSIONS: @entity12 150 mg twice daily significantly reduced the incidence of duodenal ulceration but not gastric ulceration when prescribed concomitantly with one of four commonly used non-steroidal anti-inflammatory drugs.

title: Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of XXXX .

answer: @entity12


abstract: Listeriolysin was isolated from target @entity1 erythrocyte membranes after lysis of the cells with partially purified toxin derived from a culture supernatant of @entity6 . The membrane form of the toxin exhibited properties similar to those previously found for streptolysin O. Detergent-solubilized, delipidated listeriolysin was found to comprise a heterogeneous population of partially and fully circularized, amphiphilic oligomers whose embedment within the lipid bilayer generated large transmembrane pores. The molecular weight of the toxin monomer was estimated to be 55,000 to 60,000 by @entity3 - @entity2 gel electrophoresis. Immunological cross-reactions between the toxin and @entity5 were demonstrable by @entity3 - @entity2 gel electrophoresis and immunoblotting. An immunoblot assay for detecting listeriolysin in agar-incorporated, lysed erythrocyte membranes was developed, and 28 defined, clinical isolates of @entity4 were examined for toxin production. These isolates caused beta-hemolysis on the agar plates and had previously been regarded as listeriolysin producers. However, we found that only two isolates produced genuine listeriolysin, since the sensitive immunoblot assay entirely failed to detect the toxin in all other cases. We excluded that this finding derived from proteolytic degradation of membrane-bound toxin. Thus, the great majority of @entity0 pathogenic Listeria strains appear to produce one or several hemolysins that are immunologically and, by inference, molecularly distinct from the streptolysin O-related listeriolysin. We propose that the streptolysin O-related toxin be designated alpha-listeriolysin and that the other hemolysin(s) be termed beta-listeriolysin.

title: Production of listeriolysin by beta-hemolytic strains of XXXX .

answer: @entity4


abstract: OBJECTIVE: @entity3 remains a devastating complication after @entity4 and thoracoabdominal aortic surgery for coarctations, dissections or @entity2 . Since the advent of ischaemic preconditioning of the myocardium, attention has been directed to the nervous system. This study was designed to evaluate the acute protective effect of ischaemic preconditioning on the spinal cord. MEDHODS AND RESULTS: Thirty-six New Zealand white @entity0 were randomly assigned to one of three groups. The preconditioning group had 5 minutes of @entity1 , 25 minutes reperfusion and 20 minutes of ischaemia, whereas the controls had only 20 minutes of ischaemia. The sham group was anaesthetized and subjected to laparotomy without @entity1 . Physiological parameters and somatosensory evoked potentials were monitored during the experiment. Neurological outcome was clinically evaluated up to 48 hour after ischaemia and motor function was scored. Then the animals were sacrificed. Their spinal cord, abdominal aorta and its branches were removed and processed for histopathological examination. Histhopathological changes of the gray matter in the lumbosacral segments were scored from 0 to 6 according to a @entity6 . The changes in amplitudes of evoked potentials during ischaemia and recovery periods were similar in preconditioning and control groups. The average motor function score was significantly higher in the preconditioning group than the control group at 24 and 48 hours after the ischaemic event (p < 0.05). Histological observations were consistent with the neurological findings. The histopathological scores in the control group and the preconditioning group were 3.2 (1.4-5.2) and 2.4 (0.8-4.4), respectively (p < 0.05). CONCLUSIONS: The results suggest that ischaemic preconditioning reduces the @entity5 and improves neurological outcome in transient ischaemia in @entity0 . This protective mechanism is rapidly invoked within only 25 minutes interval between the preconditioning stimulus and the ischaemic insult.

title: Ischaemic preconditioning reduces XXXX in transient ischaemia.

answer: @entity5


abstract: In this retrospective study the data of 70 @entity0 treated with streptokinase in the acute phase of @entity3 were reviewed in search of a possible relation between recurrent @entity2 and degree of anticoagulation. All @entity0 had received a 30 mn infusion of streptokinase 1.500.000 units within a mean 175 mn period from the initial symptoms. They were followed up clinically (signs of @entity4 or @entity5 ), angiographically (coronary arteriography within 5.5 days on average) and biochemically (daily measurements of @entity7 values and blood fibrinogen concentrations). Fifteen recurrent @entity2 (21.4 p. 100), including 6 attacks of @entity4 and 9 @entity3 , were observed. Angiography showed that the artery responsible for the initial @entity5 was occluded in 23.6 p. 100 (13/55) of @entity0 without recurrent @entity1 . This figure rose to 46.6 p. 100 in @entity0 who suffered a new @entity6 (7/15; NS) and up to 77 p. 100 in those who developed a new @entity3 (7/9; p less than 0.01). Biochemical data showed that 13 recurrent @entity1 occurred when the APTT values were lower than 1.5 (176 measurements), as against 2 when these values were higher than 1.5 (359 measurements) (p less than 0.01). These two recurrent @entity1 took place when fibrinogen concentrations abruptly rose above 1 g/litre. These results demonstrate that poor quality anticoagulation is responsible for the occurrence of recurrent @entity2 within days of thrombolysis for acute @entity3 . They prompt the authors to recommend anticoagulation with heparin started at an early stage and carefully adjusted by means of repeated biochemical essays.

title: [Intravenous thrombolysis in @entity3 . Influence of the quality of the anticoagulation on the early recurrence rate of @entity4 or XXXX ].

answer: @entity5


abstract: In this retrospective study the data of 70 @entity0 treated with streptokinase in the acute phase of @entity3 were reviewed in search of a possible relation between recurrent @entity2 and degree of anticoagulation. All @entity0 had received a 30 mn infusion of streptokinase 1.500.000 units within a mean 175 mn period from the initial symptoms. They were followed up clinically (signs of @entity4 or @entity5 ), angiographically (coronary arteriography within 5.5 days on average) and biochemically (daily measurements of @entity7 values and blood fibrinogen concentrations). Fifteen recurrent @entity2 (21.4 p. 100), including 6 attacks of @entity4 and 9 @entity3 , were observed. Angiography showed that the artery responsible for the initial @entity5 was occluded in 23.6 p. 100 (13/55) of @entity0 without recurrent @entity1 . This figure rose to 46.6 p. 100 in @entity0 who suffered a new @entity6 (7/15; NS) and up to 77 p. 100 in those who developed a new @entity3 (7/9; p less than 0.01). Biochemical data showed that 13 recurrent @entity1 occurred when the APTT values were lower than 1.5 (176 measurements), as against 2 when these values were higher than 1.5 (359 measurements) (p less than 0.01). These two recurrent @entity1 took place when fibrinogen concentrations abruptly rose above 1 g/litre. These results demonstrate that poor quality anticoagulation is responsible for the occurrence of recurrent @entity2 within days of thrombolysis for acute @entity3 . They prompt the authors to recommend anticoagulation with heparin started at an early stage and carefully adjusted by means of repeated biochemical essays.

title: [Intravenous thrombolysis in @entity3 . Influence of the quality of the anticoagulation on the early recurrence rate of XXXX or @entity5 ].

answer: @entity4


abstract: In this retrospective study the data of 70 @entity0 treated with streptokinase in the acute phase of @entity3 were reviewed in search of a possible relation between recurrent @entity2 and degree of anticoagulation. All @entity0 had received a 30 mn infusion of streptokinase 1.500.000 units within a mean 175 mn period from the initial symptoms. They were followed up clinically (signs of @entity4 or @entity5 ), angiographically (coronary arteriography within 5.5 days on average) and biochemically (daily measurements of @entity7 values and blood fibrinogen concentrations). Fifteen recurrent @entity2 (21.4 p. 100), including 6 attacks of @entity4 and 9 @entity3 , were observed. Angiography showed that the artery responsible for the initial @entity5 was occluded in 23.6 p. 100 (13/55) of @entity0 without recurrent @entity1 . This figure rose to 46.6 p. 100 in @entity0 who suffered a new @entity6 (7/15; NS) and up to 77 p. 100 in those who developed a new @entity3 (7/9; p less than 0.01). Biochemical data showed that 13 recurrent @entity1 occurred when the APTT values were lower than 1.5 (176 measurements), as against 2 when these values were higher than 1.5 (359 measurements) (p less than 0.01). These two recurrent @entity1 took place when fibrinogen concentrations abruptly rose above 1 g/litre. These results demonstrate that poor quality anticoagulation is responsible for the occurrence of recurrent @entity2 within days of thrombolysis for acute @entity3 . They prompt the authors to recommend anticoagulation with heparin started at an early stage and carefully adjusted by means of repeated biochemical essays.

title: [Intravenous thrombolysis in XXXX . Influence of the quality of the anticoagulation on the early recurrence rate of @entity4 or @entity5 ].

answer: @entity3


abstract: An indirect enzyme-linked immunosorbent assay (ELISA) was evaluated for the detection of anti-amoebic IgG and IgM antibodies to assess its value in distinguishing past from current @entity1 in invasive @entity4 , particularly in @entity5 ( @entity5 ) @entity0 . Using sera from 295 individuals, the ELISA was also compared with the amoebic gel diffusion (AGD) test. In 100 patients the IgG-ELISA at a single test dilution of 1/6,400 had a sensitivity of 99% for clinically diagnosed @entity5 . In these same @entity0 the IgM-ELISA at a single dilution of 1/400, had a sensitivity of 64% and a specificity of 97.9%. No cross-reactions were observed in sera from @entity0 with @entity2 . In 121 @entity0 without clinical invasive @entity4 , 8 were AGD-positive and 12 were IgG-ELISA-positive, giving the latter assay a specificity of 91.7%. This is thought to be due to past @entity1 with @entity3 . In symptomless carriers of pathogenic zymodemes, 10/11 were seropositive by the IgG-ELISA and 11/11 by the AGD test. There was an excellent correlation between the IgG-ELISA and the AGD test (r = 0.99). The IgG-ELISA is a sensitive, specific, simple and rapid test. It has the clinical advantage that results are obtainable 2 1/2 hours after receipt of the specimen, compared with the 24-48 hours required for the AGD test. The prompt availability of IgG-ELISA results could prove advantageous for implementation of early therapy. The IgM-ELISA was not found to be sensitive enough to be used as an index of active @entity1 .

title: Evaluation of an enzyme-linked immunosorbent assay in the serodiagnosis of XXXX .

answer: @entity5


abstract: The Swiss Institute for Nuclear Research SIN at Villigen is one of the three centres in the world (LAMPF, Los Alamos; TRIUMF, Vancouver) where pion therapy is possible. A dynamic, @entity2 conforming spot scan technique for the treatment of @entity2 has been in use since November 1981. With this technique with a favorable integral dose distribution, curative irradiation also of advanced @entity2 in the retroperitoneum and pelvis is possible. Only at SIN, the treatment of non-resectable soft tissue @entity3 with pions is part of the clinical program. Between 1983 and 1985 totally nine @entity0 were treated, 1/9 with three manifestations, 1/9 with palliative intent. In 20 fractions over five weeks (four fractions a week) total doses of 30 to 36 Gy (90% isodose) were applied. In a follow-up period of eleven to 43 months (median 18 months) only 1/10 @entity2 manifestations treated with greater than or equal to 30 Gy failed locally. The two-year survival rate (Kaplan-Meier) is 56%. @entity1 were the cause of death in 3/5 @entity0 , 1/5 @entity4 , 1/5 local @entity2 progression. Even though 9/11 @entity2 were located in the retroperitoneum or pelvis, no radiogenic morbidity of the bowel was found. These preliminary results stimulate the intensification of this clinical program. 1986 the same number of @entity0 with non-resectable soft tissue @entity3 was treated as in the whole period 1982 to 1985 before.

title: [Pion radiotherapy of unresectable soft tissue XXXX at the Swiss Institute for Nuclear Research].

answer: @entity3


abstract: Oxidized low-density lipoprotein (ox-LDL) induces apoptosis in endothelial cells. However, steps leading to ox-LDL-induced apoptosis remain unclear. We examined the role of ox-LDL and its newly described receptor @entity6 in the expression of intracellular pro- and antiapoptotic proteins and caspase pathways in @entity0 coronary artery endothelial cells (HCAECs). Cells were cultured and treated with different concentrations (10 to 80 microg/mL) of ox-LDL for different times (2 to 24 hours). Ox-LDL induced apoptosis in HCAECs in a concentration- and time-dependent manner. Ox-LDL also activated @entity10 and @entity2 , but not @entity9 . After ox-LDL treatment, there was a significant release of activators of @entity10 , including @entity7 and @entity11 from mitochondria to cytoplasmic compartment, and their release was not affected by treatment of cells with inhibitors of either @entity9 or @entity10 . Ox-LDL also decreased expression of antiapoptotic proteins @entity3 and c-IAP (inhibitory apoptotic protein)-1, which are involved in the release of @entity7 and @entity11 and activation of @entity10 , in a concentration- and time-dependent manner. On the other hand, ox-LDL did not change the expression of @entity4 ( @entity4 ) and proapoptotic protein Fas, which are required for the activation of @entity9 . Further, ox-LDL did not cause the truncation of @entity8 , which implies the activation of @entity9 . In other experiments, pretreatment of HCAECs with the @entity10 inhibitor @entity12 , but not the @entity9 inhibitor @entity13 , blocked ox-LDL-induced activation of @entity2 and apoptosis. As expected, pretreatment with the @entity2 inhibitor DEVD- @entity1 inhibited ox-LDL-induced activation of @entity2 and resultant apoptosis. The proapoptotic effects of ox-LDL were mediated by its receptor @entity6 , because pretreatment of HCAECs with antisense- @entity6 , but not sense- @entity6 , blocked these effects of ox-LDL. These findings suggest that ox-LDL through its receptor @entity6 decreases the expression of antiapoptotic proteins @entity3 and @entity5 . This is followed by activation of apoptotic signaling pathway, involving release of @entity7 and @entity11 and activation of @entity10 and then @entity2 .

title: Role of caspases in Ox-LDL-induced apoptotic cascade in XXXX coronary artery endothelial cells.

answer: @entity0


abstract: PURPOSE: To report the initial experience with endovascular aortic repair (EVAR) in @entity0 with @entity2 or symptomatic @entity3 ( @entity3 ) and to compare the results with conventional open surgery. METHODS: Between May 1999 and December 2001, 24 @entity0 (21 @entity0 ; mean age 75 years, range 56-89) with @entity2 or symptomatic @entity3 underwent EVAR using a specially designed aortomonoiliac endograft. Six @entity0 were selected based on device and operator availability; the subsequent 18 @entity0 were treated under a modified management protocol that offered stent-graft repair to all symptomatic @entity3 @entity0 . The results of this new treatment protocol were analyzed on an intention-to-treat basis for the last 8 months of the study. The 30-day outcomes in all @entity0 treated with emergency EVAR were compared with 40 consecutive, contemporaneous @entity0 undergoing open surgery for symptomatic or @entity4 . RESULTS: No early conversions to open surgery were performed. Significantly @entity1 and intensive care stay (p<0.05 for both) were observed in EVAR @entity0 . The mortality rate for EVAR @entity0 was 17% compared to 32% in conventionally treated @entity0 (NS). Among @entity0 with @entity4 , the 30-day mortality rates were 24% (4/17) and 41% (12/29) for EVAR and open surgery, respectively (NS). Of 26 unselected @entity0 who were treated prospectively under the modified protocol, the majority (81%, 21/26) had anatomy suitable for endovascular repair; however, only 18 (69%) underwent EVAR owing to a short infrarenal neck (n=2) or device/operator unavailability (n=6). CONCLUSIONS: EVAR is a feasible treatment in the majority of @entity0 with @entity2 or symptomatic @entity3 . The 30-day mortality appears to be similar between conventionally treated @entity0 and those undergoing endovascular repair.

title: Emergency treatment of symptomatic or XXXX : the role of endovascular repair.

answer: @entity4


abstract: Although the past number of years have seen a substantial improvement in the therapeutic approaches for the treatment of @entity1 , mortality rates continue to be high. Moreover, the incidence of @entity1 is expanding rapidly. @entity4 - @entity7 exchange ( @entity10 ) is a key target for the treatment of @entity1 . @entity10 is a major mechanism for intracellular pH regulation in most cell types, including the cardiac cell. Seven isoforms of @entity10 have been identified so far although cardiac cells possess primarily the ubiquitous @entity9 subtype. @entity9 is a major contributor to @entity8 and @entity9 inhibitors exert marked cardioprotective effects, particularly when administered before ischaemia, findings which have now been extended to clinical trials. It is emerging that @entity9 also contributes to chronic maladaptive myocardial responses to injury ( @entity0 ) and may contribute to the development of @entity1 . Experimental studies using both in vitro approaches as well as animal models of @entity1 have consistently demonstrated a beneficial effect of @entity9 inhibitors in terms of inhibition of @entity2 in response to various stimuli as well as inhibiting @entity1 after coronary artery ligation. These effects occurred independently of any @entity3 size reducing effects of @entity9 inhibitors or on any direct effects on afterload thus indicating a direct effect on the @entity0 process. In fact, it appears that @entity9 may represent a common downstream mediator for various hypertropic factors such as @entity5 , @entity6 and beta(1) adrenergic receptor activation. @entity9 inhibition, therefore, represents a potentially effective new therapeutic approach for the treatment of @entity1 .

title: Targeting the myocardial @entity4 - @entity7 exchange for treatment of XXXX .

answer: @entity1


abstract: Although the past number of years have seen a substantial improvement in the therapeutic approaches for the treatment of @entity1 , mortality rates continue to be high. Moreover, the incidence of @entity1 is expanding rapidly. @entity4 - @entity7 exchange ( @entity10 ) is a key target for the treatment of @entity1 . @entity10 is a major mechanism for intracellular pH regulation in most cell types, including the cardiac cell. Seven isoforms of @entity10 have been identified so far although cardiac cells possess primarily the ubiquitous @entity9 subtype. @entity9 is a major contributor to @entity8 and @entity9 inhibitors exert marked cardioprotective effects, particularly when administered before ischaemia, findings which have now been extended to clinical trials. It is emerging that @entity9 also contributes to chronic maladaptive myocardial responses to injury ( @entity0 ) and may contribute to the development of @entity1 . Experimental studies using both in vitro approaches as well as animal models of @entity1 have consistently demonstrated a beneficial effect of @entity9 inhibitors in terms of inhibition of @entity2 in response to various stimuli as well as inhibiting @entity1 after coronary artery ligation. These effects occurred independently of any @entity3 size reducing effects of @entity9 inhibitors or on any direct effects on afterload thus indicating a direct effect on the @entity0 process. In fact, it appears that @entity9 may represent a common downstream mediator for various hypertropic factors such as @entity5 , @entity6 and beta(1) adrenergic receptor activation. @entity9 inhibition, therefore, represents a potentially effective new therapeutic approach for the treatment of @entity1 .

title: Targeting the myocardial XXXX - @entity7 exchange for treatment of @entity1 .

answer: @entity4


abstract: Although the past number of years have seen a substantial improvement in the therapeutic approaches for the treatment of @entity1 , mortality rates continue to be high. Moreover, the incidence of @entity1 is expanding rapidly. @entity4 - @entity7 exchange ( @entity10 ) is a key target for the treatment of @entity1 . @entity10 is a major mechanism for intracellular pH regulation in most cell types, including the cardiac cell. Seven isoforms of @entity10 have been identified so far although cardiac cells possess primarily the ubiquitous @entity9 subtype. @entity9 is a major contributor to @entity8 and @entity9 inhibitors exert marked cardioprotective effects, particularly when administered before ischaemia, findings which have now been extended to clinical trials. It is emerging that @entity9 also contributes to chronic maladaptive myocardial responses to injury ( @entity0 ) and may contribute to the development of @entity1 . Experimental studies using both in vitro approaches as well as animal models of @entity1 have consistently demonstrated a beneficial effect of @entity9 inhibitors in terms of inhibition of @entity2 in response to various stimuli as well as inhibiting @entity1 after coronary artery ligation. These effects occurred independently of any @entity3 size reducing effects of @entity9 inhibitors or on any direct effects on afterload thus indicating a direct effect on the @entity0 process. In fact, it appears that @entity9 may represent a common downstream mediator for various hypertropic factors such as @entity5 , @entity6 and beta(1) adrenergic receptor activation. @entity9 inhibition, therefore, represents a potentially effective new therapeutic approach for the treatment of @entity1 .

title: Targeting the myocardial @entity4 - XXXX exchange for treatment of @entity1 .

answer: @entity7


abstract: Twenty-five hypercholesterolaemic @entity0 from three centres in the UK were investigated in an open study of the efficacy and side effects of @entity5 . Five @entity0 dropped out of the study at an early stage and had insufficient data for analysis. There were 13 males and 7 females (mean age 49.2 years, range 18-69). Fourteen @entity0 had heterozygous @entity4 , and six polygenic hypercholesterolaemia. @entity5 was started at a dose of 750 mg/day and this was increased at weekly intervals over 4 weeks to the maximum tolerated dosage up to 3 g/day. This was then maintained for a further 8 weeks. There were statistically significant decreases in total plasma @entity1 , total @entity2 , LDL @entity1 and VLDL @entity2 ; HDL @entity1 remained unchanged after 12 weeks of treatment (Wilcoxon matched pairs, signed ranks test). The 14 @entity0 with @entity4 showed a 13.9% fall in total @entity1 and a 19.8% fall in LDL @entity1 . All @entity0 reported @entity3 and some had gastrointestinal symptoms but 19 would have been prepared to continue with the therapy at doses up to 3 g/day. Thus @entity5 has been found to be beneficial in the treatment of both @entity4 .

title: Clinical and laboratory responses to XXXX in the treatment of hypercholesterolaemia.

answer: @entity5


abstract: The enumeration of faecal bacteria is an important requirement for many studies of bowel health. One approach is the use of selective culture media for the culture and identification of genera or species from faeces. This study compares the culture of Lactobacilli from dilution series of faecal samples from six healthy @entity0 volunteers on two commonly used media, LAMVAB and Rogosa agar. Colonies were counted after a 72-h anaerobic incubation at 37 degrees C, and colony morphology recorded by a single observer. DNA was isolated from a representative number of colonies and genus-specific PCR, single-stranded conformation polymorphism (SSCP) and DNA sequencing performed. Total colony counts ranged from <3.00 to 7.48 log(10) cfu/g of faeces for LAMVAB and 5.09 to 7.66 log(10) cfu/g for Rogosa. For each subject, the total colony count was higher on Rogosa than that obtained with LAMVAB agar. SSCP analysis and DNA sequencing indicated that colony morphology was not an accurate predictor of genus identity. Growth of two species, @entity1 and @entity2 , was not supported on LAMVAB medium. Rogosa agar was more likely to support growth of non- @entity2 species. Therefore, neither medium gave a fully accurate representation of the Lactobacilli species present in @entity0 faecal samples.

title: Comparison of two selective media for the detection and enumeration of Lactobacilli in XXXX faeces.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: Despite the widespread use of angioplasty, adjunct chemical therapy is often needed to treat @entity0 with @entity4 . In this study, we examined the safety of intraarterial administration of @entity3 to @entity0 with @entity4 . We herein summarize our 2-year experience with this treatment. METHODS: We retrospectively reviewed the procedure reports, anesthesia records, clinical charts, and brain images of 29 @entity0 who received intraarterially administered @entity3 in 34 procedures for the treatment of @entity4 after @entity2 from July 1998 to June 2000. The average changes in mean arterial pressure and heart rate were used to measure cardiovascular side effects. The neurologic effects were assessed by angiographic findings, the results of neurologic examinations performed before and after the procedure, and findings of CT of the head. RESULTS: The average dose of @entity3 per @entity0 was 3 +/- 0 mg or 44 +/- 5 mcg/kg. The average changes in mean arterial pressure at 10 and 20 minutes were -5 +/- 1 mm Hg and -2 +/- 1 mm Hg or -3.8 +/- 1.0% and -1.7 +/- 1.1%, respectively. No significant change of heart rate was observed at 10 minutes. The @entity0 showed no sign of @entity1 by hemodynamic parameters, neurologic examination, or CT of the head. On 10 occasions, when the effect of @entity3 infusion was assessed angiographically, there was 44 +/- 9% increase of vessel diameter in the spastic segment. Neurologic improvement was noted after five of 17 procedures when @entity3 was used as the sole treatment. CONCLUSION: Low dose @entity3 is safe when administered intraarterially to @entity0 with @entity4 . Beneficial effects are achieved in some @entity0 , prompting further study of its efficacy.

title: Intraarterially administered XXXX as adjunct therapy for @entity4 : safety and 2-year experience.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: Despite the widespread use of angioplasty, adjunct chemical therapy is often needed to treat @entity0 with @entity4 . In this study, we examined the safety of intraarterial administration of @entity3 to @entity0 with @entity4 . We herein summarize our 2-year experience with this treatment. METHODS: We retrospectively reviewed the procedure reports, anesthesia records, clinical charts, and brain images of 29 @entity0 who received intraarterially administered @entity3 in 34 procedures for the treatment of @entity4 after @entity2 from July 1998 to June 2000. The average changes in mean arterial pressure and heart rate were used to measure cardiovascular side effects. The neurologic effects were assessed by angiographic findings, the results of neurologic examinations performed before and after the procedure, and findings of CT of the head. RESULTS: The average dose of @entity3 per @entity0 was 3 +/- 0 mg or 44 +/- 5 mcg/kg. The average changes in mean arterial pressure at 10 and 20 minutes were -5 +/- 1 mm Hg and -2 +/- 1 mm Hg or -3.8 +/- 1.0% and -1.7 +/- 1.1%, respectively. No significant change of heart rate was observed at 10 minutes. The @entity0 showed no sign of @entity1 by hemodynamic parameters, neurologic examination, or CT of the head. On 10 occasions, when the effect of @entity3 infusion was assessed angiographically, there was 44 +/- 9% increase of vessel diameter in the spastic segment. Neurologic improvement was noted after five of 17 procedures when @entity3 was used as the sole treatment. CONCLUSION: Low dose @entity3 is safe when administered intraarterially to @entity0 with @entity4 . Beneficial effects are achieved in some @entity0 , prompting further study of its efficacy.

title: Intraarterially administered @entity3 as adjunct therapy for XXXX : safety and 2-year experience.

answer: @entity4


abstract: The @entity4 signalosome (CSN) is an essential eight-subunit repressor of light-regulated development in @entity3 . This complex has also been identified in animals, though its developmental role remains obscure. CSN subunits have been implicated in various cellular processes, suggesting a possible role for the CSN as an integrator of multiple signaling pathways. In order to elucidate the function of the CSN in animals, a @entity2 model system has previously been established. Gel-filtration analysis with antibodies against CSN subunits 4, 5 and 7 revealed that these proteins act as a complex in @entity2 that is similar in size to the plant and @entity0 complexes. Null mutations in either one of two subunits, @entity5 or @entity6 , are larval lethal. Successful embryogenesis appears to be a consequence of maternal contribution of the complex. Biochemical analysis indicates that the different subunits are found in both CSN-dependent and CSN-independent forms, and that these forms are differentially affected by the mutations. Phenotypic characterization of these two mutants indicates that they show both shared and unique phenotypes, which suggest specific roles for each subunit. Both mutants have defective oocyte and embryo patterning, and defects in response to DNA damage, while @entity6 mutants develop @entity1 and @entity5 mutants have phenotypes reminiscent of defects in ecdysone signaling.

title: COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in XXXX .

answer: @entity2


abstract: OBJECTIVE: The objective of the present study was to determine the effectiveness of functional treatment for distal third humeral shaft @entity2 in young adults. @entity0 AND METHODS: A custom-made prefabricated brace was applied for the functional treatment of 21 isolated, closed, distal third humeral shaft @entity2 of 21 @entity0 (17 male and 4 female). Their average age was 25 years (range 18-37 years). The mean follow-up period was 39 weeks. RESULTS: All of the @entity2 united. The average time to union was 12 weeks. The average varus angulation was 7.8 deg in 8 @entity0 , and the average shortening of the fractured limb was 10 mm in 4 @entity0 . Minimal motion restrictions mostly occurred in shoulder abduction and lateral rotation. No @entity0 showed a lack of elbow motion. @entity1 and shortening had no effect on the functional outcome. None of the @entity0 suffered @entity3 during the course of treatment or due to entrapment in the callus of the healed @entity2 . CONCLUSIONS: Young adults who have isolated, closed, distal third humeral shaft @entity2 are good candidates for functional bracing.

title: Functional treatment of the distal third humeral shaft XXXX .

answer: @entity2


abstract: A 36-year-old @entity0 was referred with @entity6 and recurrent episodes of @entity10 . Two years prior to her visit, she underwent transurethral resection of a @entity3 , 5 cm in diameter. Total cystectomy was suggested, as the initial diagnosis was @entity4 . Close re-evaluation of the pathological specimen lead to the final diagnosis of a benign @entity12 of the bladder as the @entity1 consisted of smooth muscle cells with white blood cell infiltration but without mitotic figures. The @entity1 disappeared during the follow up period. A cystography revealed bilateral vesicoureteral reflux with marked @entity7 . A cystometry showed @entity7 and a @entity7 without detrusor contraction. Neurological examination and a magnetic resonance imaging of the spinal cord failed to prove the presence of definite @entity2 . She was finally diagnosed with @entity8 of unknown origin. In this case, she had been suffering from @entity9 about 6 years before the resection of @entity3 and it was suggested that the occurrence of the @entity7 would be related with @entity5 due to @entity8 . @entity6 and @entity5 were controlled successfully with clean intermittent self-catheterization and adequate administration of antimicrobial drugs. @entity11 was treated with injection of @entity13 collagen into the ureteral orifices. No @entity1 recurrence has been found up to the present time, 5 years after the resection of @entity3 .

title: [A case of XXXX with @entity12 of the bladder].

answer: @entity8


abstract: A 36-year-old @entity0 was referred with @entity6 and recurrent episodes of @entity10 . Two years prior to her visit, she underwent transurethral resection of a @entity3 , 5 cm in diameter. Total cystectomy was suggested, as the initial diagnosis was @entity4 . Close re-evaluation of the pathological specimen lead to the final diagnosis of a benign @entity12 of the bladder as the @entity1 consisted of smooth muscle cells with white blood cell infiltration but without mitotic figures. The @entity1 disappeared during the follow up period. A cystography revealed bilateral vesicoureteral reflux with marked @entity7 . A cystometry showed @entity7 and a @entity7 without detrusor contraction. Neurological examination and a magnetic resonance imaging of the spinal cord failed to prove the presence of definite @entity2 . She was finally diagnosed with @entity8 of unknown origin. In this case, she had been suffering from @entity9 about 6 years before the resection of @entity3 and it was suggested that the occurrence of the @entity7 would be related with @entity5 due to @entity8 . @entity6 and @entity5 were controlled successfully with clean intermittent self-catheterization and adequate administration of antimicrobial drugs. @entity11 was treated with injection of @entity13 collagen into the ureteral orifices. No @entity1 recurrence has been found up to the present time, 5 years after the resection of @entity3 .

title: [A case of @entity8 with XXXX of the bladder].

answer: @entity12


abstract: A programme for the control of @entity1 caused by @entity2 in @entity0 was launched in 1970 and continued until 1985. The animals were subjected to helminth-control treatment and preventive measures were taken in the herds. The anti-fasciolics Bilevon M and to some extent also Bromsalan pulv. were administered by the veterinary service on the basis of state subsidies in 1973 to 1979. The preparation Helmisan (Spofa) has been in use since 1980; its production is subsidized by the agricultural enterprises. In the period from 1972 ot 1979, up to 213 thousand helminth-control treatments (both therapeutic and preventive) were performed every year in the @entity0 . All treatments reduced the occurrence of @entity2 and pathological changes in the liver of the killed @entity0 (from 5.8% recorded in 1971 to 0.9 in 1980, on an national average). As a result, 29 districts are free from @entity1 although the disease originally occurred in all districts of the Czech Socialist Republic. After ten years of purposeful use of antifasciolics, the findings were free from living flukes and the @entity0 only showed pathological changes after the action of @entity2 . Since 1980 the extensity of the findings of @entity2 in slaughtered @entity0 has ranged within one percent, though living flukes have recently occurred again in the liver of certain animals. In the enzootically affected regions and districts of the Czech Socialist Republic the @entity1 control programme succeeded in reducing the number of invaded @entity0 herds.

title: [Control of XXXX in heifers in Czechoslovakia 1970-1985].

answer: @entity1


abstract: Echocardiography evaluates the severity of @entity3 from its repercussions on haemodynamics. However, many authors have reported the discovery of @entity1 in the right heart cavities of @entity0 with @entity3 . In order to assess the frequency of intracavitary @entity1 and to evaluate the practical problems it raises, we have systematically examined by echocardiography 84 @entity0 hospitalized for severe, @entity3 (mean Miller's score: 21). In this series of 39 @entity0 and 45 @entity0 (mean age 62 years), 9 thrombi were detected, i.e. an incidence of 11%. Depending on the ultrasonographic images they presented, these @entity0 were divided into two groups: 1. Six @entity0 with low mobility thrombi attached to the cardiac wall. All benefited from a medical treatment consisting of heparin in 4 cases and a thrombolytic drug in 2 cases. There was no clinical evidence of recurrent @entity2 . Echocardiography showed complete disappearance of the thrombi in 5 of these 6 @entity0 and partial regression under heparin therapy in one. 2. Three @entity0 with a large and mobile @entity1 threatening to prolapse through the tricuspid valve during atrial systole. It seemed rational to regard such thrombi as carrying a high risk of @entity2 with recurrences, especially since they had formed in @entity0 already with severe @entity3 . This view was confirmed by a search in the literature which yielded a 40% death rate figure when these thrombi were associated with @entity3 . This high mortality, however, can be reduced by diagnostic and therapeutic measures.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Detection by echocardiography of a @entity1 of the right cavities in XXXX ].

answer: @entity3


abstract: Echocardiography evaluates the severity of @entity3 from its repercussions on haemodynamics. However, many authors have reported the discovery of @entity1 in the right heart cavities of @entity0 with @entity3 . In order to assess the frequency of intracavitary @entity1 and to evaluate the practical problems it raises, we have systematically examined by echocardiography 84 @entity0 hospitalized for severe, @entity3 (mean Miller's score: 21). In this series of 39 @entity0 and 45 @entity0 (mean age 62 years), 9 thrombi were detected, i.e. an incidence of 11%. Depending on the ultrasonographic images they presented, these @entity0 were divided into two groups: 1. Six @entity0 with low mobility thrombi attached to the cardiac wall. All benefited from a medical treatment consisting of heparin in 4 cases and a thrombolytic drug in 2 cases. There was no clinical evidence of recurrent @entity2 . Echocardiography showed complete disappearance of the thrombi in 5 of these 6 @entity0 and partial regression under heparin therapy in one. 2. Three @entity0 with a large and mobile @entity1 threatening to prolapse through the tricuspid valve during atrial systole. It seemed rational to regard such thrombi as carrying a high risk of @entity2 with recurrences, especially since they had formed in @entity0 already with severe @entity3 . This view was confirmed by a search in the literature which yielded a 40% death rate figure when these thrombi were associated with @entity3 . This high mortality, however, can be reduced by diagnostic and therapeutic measures.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Detection by echocardiography of a XXXX of the right cavities in @entity3 ].

answer: @entity1


abstract: Listeriosis, caused by @entity6 , appears to be increasing in incidence worldwide. The disease is of great concern to the food industry. A recent outbreak in California was linked to the consumption of Mexican-style soft cheese and involved more than 300 cases, 30% of which were fatal. @entity6 can be found in a variety of dairy products, leafy vegetables, fish and meat products. It can grow in refrigerated foods and is more heat resistant than most vegetative microbes. The epidemiologic features of listeriosis are poorly understood, and the minimum infectious dose is unknown. Those predisposed to listeriosis include immunocompromised @entity0 and pregnant @entity0 and their fetuses. @entity2 , @entity4 and @entity1 are the primary manifestations of the disease. Early recognition is critical for successful treatment, and @entity3 is the preferred drug. Listeriosis should be considered in any febrile @entity0 with neurologic symptoms of unknown origin, as well as in @entity0 with unexplained recurrent miscarriages, @entity5 or @entity7 . A food source should be the prime suspect if any isolated case or outbreak occurs.

title: XXXX : a foodborne pathogen.

answer: @entity6


abstract: In a phase II study, 16 adult @entity0 with locally advanced or metastatic soft tissue @entity2 were treated with i.v. infusions of @entity4 /mesna 5 g/m2 plus i.v. @entity3 40 mg/m2. Courses were given every 3 weeks up to a maximum of six courses in responding @entity0 . Six @entity0 (37.5%) had either complete (1 @entity0 ) or partial responses (5 @entity0 ). Confidence limits for this response rate were 15.2%-64.5% (95% confidence level). There was one toxic death in association with @entity1 , renal and @entity5 . Unilateral pneumothoraces occurred in 2 @entity0 with large pulmonary metastases. Recurrent severe @entity4 /mesna @entity1 occurred in 2 @entity0 at risk for this complication; @entity0 who develop severe @entity4 /mesna @entity1 should not be retreated with this drug. @entity4 /mesna with @entity3 is an active combination to treat @entity2 but, despite the feasibility of the combination, sequential monotherapy with these drugs might provide similar or better clinical benefit.

title: A phase II study of @entity4 /mesna with XXXX for @entity2 .

answer: @entity3


abstract: In a phase II study, 16 adult @entity0 with locally advanced or metastatic soft tissue @entity2 were treated with i.v. infusions of @entity4 /mesna 5 g/m2 plus i.v. @entity3 40 mg/m2. Courses were given every 3 weeks up to a maximum of six courses in responding @entity0 . Six @entity0 (37.5%) had either complete (1 @entity0 ) or partial responses (5 @entity0 ). Confidence limits for this response rate were 15.2%-64.5% (95% confidence level). There was one toxic death in association with @entity1 , renal and @entity5 . Unilateral pneumothoraces occurred in 2 @entity0 with large pulmonary metastases. Recurrent severe @entity4 /mesna @entity1 occurred in 2 @entity0 at risk for this complication; @entity0 who develop severe @entity4 /mesna @entity1 should not be retreated with this drug. @entity4 /mesna with @entity3 is an active combination to treat @entity2 but, despite the feasibility of the combination, sequential monotherapy with these drugs might provide similar or better clinical benefit.

title: A phase II study of XXXX /mesna with @entity3 for @entity2 .

answer: @entity4


abstract: In a phase II study, 16 adult @entity0 with locally advanced or metastatic soft tissue @entity2 were treated with i.v. infusions of @entity4 /mesna 5 g/m2 plus i.v. @entity3 40 mg/m2. Courses were given every 3 weeks up to a maximum of six courses in responding @entity0 . Six @entity0 (37.5%) had either complete (1 @entity0 ) or partial responses (5 @entity0 ). Confidence limits for this response rate were 15.2%-64.5% (95% confidence level). There was one toxic death in association with @entity1 , renal and @entity5 . Unilateral pneumothoraces occurred in 2 @entity0 with large pulmonary metastases. Recurrent severe @entity4 /mesna @entity1 occurred in 2 @entity0 at risk for this complication; @entity0 who develop severe @entity4 /mesna @entity1 should not be retreated with this drug. @entity4 /mesna with @entity3 is an active combination to treat @entity2 but, despite the feasibility of the combination, sequential monotherapy with these drugs might provide similar or better clinical benefit.

title: A phase II study of @entity4 /mesna with @entity3 for XXXX .

answer: @entity2


abstract: To demonstrate a relationship between diarrheal incidence and the onset of @entity3 developing as a result of acute @entity4 and severe catabolism, we initially studied two @entity0 who had developed severe @entity3 (less than 2.5 g/dl) and @entity1 on a variety of enteral diets. Each @entity0 was placed on a peptide enteral formula at a rate of infusion equivalent to that used during the previous 24 h. Diarrheal volumes decreased significantly from greater than 1500 to less than 100 ml/day and from greater than 4000 to 800 ml/day. We subsequently studied 12 @entity0 in a randomized, prospective fashion to confirm our previous observations. Seven @entity0 received a peptide enteral formula, and five received a standard isotonic enteral formula as a control. The @entity0 were monitored for a minimum of 2 wk or until serum @entity2 levels reached 3 g/dl. Nutritional variables were measured initially and every 4 days for the duration of the study. Of the @entity0 receiving the isotonic feeding, only one of five completed the study period without @entity1 . Two @entity0 died unrelated to the feeding, and three @entity0 developed severe @entity1 within 48 h of institution of the study. Of the seven @entity0 receiving the peptide feeding, six completed the study period without @entity1 . One @entity0 had a large stool volume initially which decreased by day 2 of the study. We conclude that a peptide enteral formula is well tolerated in @entity0 with severe @entity3 when compared to a standard isotonic enteral formula. The ability to provide enteral nutrition in a form that is well tolerated in @entity3 @entity0 may obviate the need for parenteral nutrition routinely in these @entity0 .

title: XXXX associated with severe @entity3 : a comparison of a peptide-based chemically defined diet and standard enteral alimentation.

answer: @entity1


abstract: To demonstrate a relationship between diarrheal incidence and the onset of @entity3 developing as a result of acute @entity4 and severe catabolism, we initially studied two @entity0 who had developed severe @entity3 (less than 2.5 g/dl) and @entity1 on a variety of enteral diets. Each @entity0 was placed on a peptide enteral formula at a rate of infusion equivalent to that used during the previous 24 h. Diarrheal volumes decreased significantly from greater than 1500 to less than 100 ml/day and from greater than 4000 to 800 ml/day. We subsequently studied 12 @entity0 in a randomized, prospective fashion to confirm our previous observations. Seven @entity0 received a peptide enteral formula, and five received a standard isotonic enteral formula as a control. The @entity0 were monitored for a minimum of 2 wk or until serum @entity2 levels reached 3 g/dl. Nutritional variables were measured initially and every 4 days for the duration of the study. Of the @entity0 receiving the isotonic feeding, only one of five completed the study period without @entity1 . Two @entity0 died unrelated to the feeding, and three @entity0 developed severe @entity1 within 48 h of institution of the study. Of the seven @entity0 receiving the peptide feeding, six completed the study period without @entity1 . One @entity0 had a large stool volume initially which decreased by day 2 of the study. We conclude that a peptide enteral formula is well tolerated in @entity0 with severe @entity3 when compared to a standard isotonic enteral formula. The ability to provide enteral nutrition in a form that is well tolerated in @entity3 @entity0 may obviate the need for parenteral nutrition routinely in these @entity0 .

title: @entity1 associated with severe XXXX : a comparison of a peptide-based chemically defined diet and standard enteral alimentation.

answer: @entity3


abstract: The authors report on their experience with endoscopic treatment of @entity5 . Out of a total of 363 successful procedures of endoscopic papillosphincterotomy (EPS), @entity5 was the indication for EPS in 270 @entity0 (74.4%). Most often, EPS and extraction were performed in @entity0 after cholecystectomy (79.6%) and those with @entity5 and an in situ gallbladder, but free of stones (13.4%). In @entity0 with concomitant @entity7 , EPS was carried out only in those cases in which surgery was contraindicated. EPS was performed in four cases of @entity3 . Removal of stones from the choledochus was successful in 95.5%. Of the total of 363 successful EPS's, complications were observed in 17 cases (4.7%), with a mortality of 1.1% (4 deaths). Most frequently, the causes included @entity2 (1.9%) and perforation (1.1%). Of other complications, the authors noted acute @entity4 , acute @entity1 and @entity6 in the hepatocholedochus in two cases each. The complications required emergency surgery in six @entity0 (35.3%).

title: Endoscopic treatment of XXXX .

answer: @entity5


abstract: The tendency of a @entity0 to approach the wall of an open-field and to travel along the perimeter of the field (termed as "peritaxis" or "wall-facing") is affected by unilateral removal of the vibrissae. Peritaxis is lateralized by hemivibrissotomy. The finding that the @entity1 agonist @entity3 reversed the direction of wall-facing asymmetry after 10 days of vibrissae removal suggested a link between this sensorimotor asymmetry and @entity1 transmission. The present experiment examined the influence of a unilateral injection of @entity2 into the substantia nigra on peritaxis and compared this behavioral measure with turning behavior as an index of lesion-induced sensorimotor asymmetries and of recovery of function. The lesion of the substantia nigra reduced wall-facing with the side contralateral to the lesion to near-zero values. During the first week after the injection animals with incomplete @entity1 depletion recovered from this asymmetry. The changes in wall-facing behavior were paralleled by turning asymmetries. Wall-facing was at least as sensitive to application of @entity4 and @entity3 as turning behavior. We concluded that lateralized wall-facing, or peritaxis, can serve as a useful index of dysfunction in the nigrostriatal @entity1 system and the influence of catecholaminergic drugs. Wall-facing can also serve as a measure of recovery of function.

title: Lateralized wall-facing versus turning as measures of behavioral asymmetries and recovery of function after injection of XXXX into the substantia nigra.

answer: @entity2


abstract: The major isotype of parvalbumin has been isolated from the skeletal muscle of the toad, @entity7 . Unlike the skeletal muscle of every frog so far examined (Rana esculenta, Rana temporaria, and Rana catesbeiana), which contains two major isotypes of parvalbumins, toad skeletal muscle has been shown to contain only one isotype, but the content of parvalbumin in toad skeletal muscle was similar to the sum of those of the two isotypes in skeletal muscles of frogs. This feature of toad skeletal muscle is advantageous to clarify the physiological role of parvalbumin. The relative molecular mass of toad parvalbumin was estimated to be 12,200 by @entity1 - @entity6 gel electrophoresis. The isoelectric point was determined to be 4.81 by @entity6 gel isoelectric focusing. The @entity2 composition indicated that toad parvalbumin corresponds to bullfrog (R. catesbeiana) pI 4.97 parvalbumin, showing that toad parvalbumin is genetically an alpha-parvalbumin. It was also revealed by the @entity2 composition that toad parvalbumin is distinctly different from any of the parvalbumins from frogs. The ultraviolet spectrum of toad parvalbumin is consistent with its @entity2 composition. The ultraviolet difference spectrum of the @entity0 -loaded form vs. the metal-free form indicates that some @entity3 residues in the toad parvalbumin molecule are affected by a conformational change associated with @entity0 binding. On electrophoresis in @entity6 gel in 14 mM Tris and 90 mM @entity5 , the metal-free and @entity4 -loaded forms of toad parvalbumin migrated twice as fast as the @entity0 -loaded form.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Preparation and characterization of the major isotype of parvalbumin from skeletal muscle of the toad ( XXXX ).

answer: @entity7


abstract: Sequence comparisons were made for up to 667 bp of DNA cloned from 14 kinds of Hawaiian @entity1 and five other dipteran species. These sequences include parts of the genes for @entity3 dehydrogenase (subunits 1, 2, and 5) and rRNA (from the large ribosomal subunit). Because the times of divergence among these species are known approximately, the sequence comparisons give insight into the evolutionary dynamics of this molecule. Transitions account for nearly all of the differences between sequences that have diverged by less than 2%: for these sequences the mean rate of divergence appears to be about 2%/ @entity4 . In comparisons involving greater divergence times and greater sequence divergence, relatively more of the sequence differences are due to transversions. Specifically, the fraction of these differences that are counted as transversions rises from an initial value of less than 0.1 to a plateau value of nearly 0.6. The time required to reach half of the plateau value, about 10 Myr, is similar to that for @entity0 mtDNA. The mtDNAs of flies and mammals are also alike in the shape of the curve relating the percentage of positions at which there are differences in protein-coding regions to the time of divergence. For both groups of animals, the curve has a steep initial slope ascribable to fast accumulation of synonymous substitutions and a shallow final slope resulting from the slow accumulation of substitutions causing @entity2 replacements. However, the percentage of all sites that can experience a high rate of substitution appears to be only about 8% for @entity1 mtDNA compared to about 20% for @entity0 mtDNA.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Tempo and mode of sequence evolution in mitochondrial DNA of Hawaiian XXXX .

answer: @entity1


abstract: Serum inhibin levels were measured by RIA twice weekly for 4 weeks in 5 @entity0 with the @entity3 ( @entity3 ). These were compared to those in 10 @entity0 with normal menstrual cycles. Serum inhibin levels were similar in the 5 @entity3 @entity0 (mean, 199; range, 126-266 U/L) and were not significantly different from those in the normal @entity0 during the early follicular phase (227; 100-485 U/L) or midfollicular phase (243; 143-412 U/L) of their cycles. Inhibin levels were higher (P less than 0.001) in the late follicular phase (408; 227-732 U/L), at midcycle (623; 367-1058 U/L), and during the midluteal phase (1245; 898-1727 U/L) in the normal @entity0 compared to those in the @entity3 group. Serum inhibin levels were also measured in @entity3 (n = 8) and @entity2 (n = 14) @entity0 after the rise and subsequent diminished gonadotropin secretion that occurred during LHRH agonist administration. In both groups, serum LH and FSH increased after initiation of LHRH agonist administration; this increase was accompanied by parallel rises in serum @entity1 and inhibin before suppression ( @entity3 @entity0 : r = 0.71; P less than 0.001; n = 108; @entity2 @entity0 : r = 0.42; P less than 0.05; n = 163). All hormone levels, including inhibin, decreased during continued LHRH administration. Five @entity3 @entity0 underwent ovulation induction using combined LHRH agonist and @entity0 menopausal gonadotropin administration. Serum @entity1 and inhibin rose in parallel in response to exogenous gonadotropins (r = 0.92; P less than 0.001; n = 77). In conclusion, we found no evidence of a primary defect in ovarian inhibin physiology in @entity0 with @entity3 in terms of either basal or gonadotropin-stimulated (exogenous or endogenous) secretion.

title: Serum inhibin levels in XXXX : basal levels and response to luteinizing hormone-releasing hormone agonist and exogenous gonadotropin administration.

answer: @entity3


abstract: Incubation of nerve with @entity4 and the divalent cation ionophores @entity8 or @entity7 , causes a prompt vesiculation of the myelin at the paranodes and Schmidt-Lanterman incisures. The vesiculation appears to be dependent upon a rise in the intracellular @entity5 concentration of the affected Schwann cells. To determine whether a similar vesiculation might occur in vivo, and to examine the long term consequences of ionophore exposure, the sciatic nerves of @entity2 and @entity1 were injected with @entity7 and examined histologically after intervals of 1 h to 75 days. A prompt myelin vesiculation was again observed, and this spread from the paranodes and incisures to invade regions of formerly compact myelin: segmentally demyelinated axons were common 7 days post-injection. The lesions were large, and involved up to 95% of the fibres in the @entity1 . There was little evidence of either @entity3 , or @entity6 in either species. The appearance and spatio-temporal progression of the lesion was strikingly similar to that seen after the intraneural injection of @entity9 or phospholipase A2. However, in the ionophore lesion, not all the @entity0 was effected by myelin vesiculation, for up to 30% of the affected fibres showed evidence of macrophage-mediated stripping. Macrophage stripping was confined to internodes already affected by vesiculation. Most of the myelin debris was removed by macrophages, and myelin debris was only rarely observed within Schwann cells. Remyelination was initiated in nearly all the affected fibres by 21 days, and by 2 months all affected fibres were invested with thin, new myelin sheaths. These findings may be relevant to immune-mediated @entity0 .

title: Peripheral demyelination and remyelination initiated by the @entity5 -selective ionophore XXXX : in vivo observations.

answer: @entity7


abstract: Incubation of nerve with @entity4 and the divalent cation ionophores @entity8 or @entity7 , causes a prompt vesiculation of the myelin at the paranodes and Schmidt-Lanterman incisures. The vesiculation appears to be dependent upon a rise in the intracellular @entity5 concentration of the affected Schwann cells. To determine whether a similar vesiculation might occur in vivo, and to examine the long term consequences of ionophore exposure, the sciatic nerves of @entity2 and @entity1 were injected with @entity7 and examined histologically after intervals of 1 h to 75 days. A prompt myelin vesiculation was again observed, and this spread from the paranodes and incisures to invade regions of formerly compact myelin: segmentally demyelinated axons were common 7 days post-injection. The lesions were large, and involved up to 95% of the fibres in the @entity1 . There was little evidence of either @entity3 , or @entity6 in either species. The appearance and spatio-temporal progression of the lesion was strikingly similar to that seen after the intraneural injection of @entity9 or phospholipase A2. However, in the ionophore lesion, not all the @entity0 was effected by myelin vesiculation, for up to 30% of the affected fibres showed evidence of macrophage-mediated stripping. Macrophage stripping was confined to internodes already affected by vesiculation. Most of the myelin debris was removed by macrophages, and myelin debris was only rarely observed within Schwann cells. Remyelination was initiated in nearly all the affected fibres by 21 days, and by 2 months all affected fibres were invested with thin, new myelin sheaths. These findings may be relevant to immune-mediated @entity0 .

title: Peripheral demyelination and remyelination initiated by the XXXX -selective ionophore @entity7 : in vivo observations.

answer: @entity5


abstract: Clinical and statistical investigations were performed on 157 @entity0 with @entity3 in the Third Teaching Hospital, Normal Bethune University experienced between January, 1950 and June, 1986. The number of @entity0 with @entity3 among other hospitalized @entity0 showed a recent gradual increase. The @entity0 's age at the time the disease was first diagnosed was most frequently between 60 and 69 years old with an average age of 63.3 years. Dysuria was the most prominent symptom, followed by frequency, retention and macroscopic @entity5 . Duration between initial symptom and diagnosis was one to two years in most @entity0 . The @entity6 could be detected by rectal examination in all @entity0 . Elevation of serum acid phosphatase was found in 24.4%. Such elevation was evident in 52.2% of the @entity0 with metastatic lesions, compared to 14.4% of those without @entity1 . Fourteen @entity0 had @entity1 to bone (8.9%), 13 to lymph nodes, 2 to lung and one to liver. According to the staging diagnosis, 19 @entity0 (12.1%) had stage A, 78 @entity0 (49.7%) had stage B, 20 @entity0 (12.7%) had stage C and 40 @entity0 (25.5%) had stage D @entity2 . Histological findings in 57 @entity0 indicated @entity4 ; 39 cases (68.4%) were poorly differentiated, 12 cases (21.2%) were moderately differentiated and 6 cases (10.5%) were well differentiated. Modality of treatment was total prostatectomy in 2 cases (1.3%), antiandrogen therapy (orchiectomy and/or @entity7 ) in 122 cases (77.7%), subcapsular prostatectomy in 7 cases (4.5%), symptomatic treatment in 5 cases and no treatment in 23 cases (14.6%).

title: [Clinical investigation of XXXX in the Third Teaching Hospital of Norman Bethune University of Medical Sciences].

answer: @entity3


abstract: BACKGROUND: The present study aimed to clarify the proliferation and apoptosis of parenchymal cells during regeneration of @entity0 submandibular glands following @entity1 . METHODS: Atrophy of the right submandibular gland of @entity0 was induced by excretory duct ligation at the hilum with metal clips, which were removed 1 week (day 0) after ligation. The right submandibular glands were collected from 0 to 14 days after removal of the clips and investigated using immunohistochemistry for @entity2 ( @entity2 ) as a marker of proliferating cells, @entity5 ( @entity5 )-mediated @entity3 -digoxigenin nick end labeling (TUNEL) as a marker of apoptotic cells, and transmission electron microscopy (TEM). RESULTS: After 1 week of ligation, there were many remaining ducts and a few acini in the @entity4 . At day 3 after discontinuing the ligation, newly formed acini appeared and thereafter increased in number and maturity. Many residual and newly formed acinar cells showed positive reaction to @entity2 especially at days 4 and 5. The @entity2 -positive duct cells decreased in number with the regeneration. A few TUNEL-positive acinar and duct cells were identified during regeneration. Mitosis and apoptosis of parenchymal cells were also identified by TEM. CONCLUSIONS: During regeneration of the submandibular gland after @entity1 , both residual and newly formed acinar cells proliferate actively. There is also apoptosis of parenchymal cells; however, the significance of apoptosis is low.

title: Cell death and cell proliferation in the regeneration of atrophied XXXX submandibular glands after duct ligation.

answer: @entity0


abstract: BACKGROUND: @entity4 is a rare @entity5 . Recently, a more @entity3 , so-called "proximal type" @entity4 has been described. CLINICAL CASE: A 40-year-old- @entity0 presented with 5 x 4 cm, erythematous, indurated, non-movable, painful mass on the pubic area. Histopathology demonstrated @entity1 -cell infiltration into the subcutaneous and fascia, which was consisted of prominent epithelioid cells and scattered rhabdoid cells. A multinodular growth pattern or granulomatous appearance with central @entity2 was not observed. The @entity1 cells showed positive reactions for @entity9 , cytokeratin ( @entity7 / @entity8 ), and @entity10 . Despite the surgery, left inguinal mass with @entity11 occurred one month later. We also carried out comparative genomic hybridization (CGH) with @entity1 cells. CGH revealed @entity6 of 5q32-qter, 12q24-qter, and 22q. CONCLUSION: We report a case of proximal-type of @entity4 , which showed the chromosomal gains of 5q32-qter, 12q24-qter, and 22q by CGH.

title: XXXX : case report and result of comparative genomic hybridization.

answer: @entity4


abstract: @entity4 ( @entity4 ) is characterized by: i). the en bloc resection of the uterus, proximal vagina, and mesometrium as a developmentally defined entity; ii). transection of the rectouterine dense subperitoneal connective tissue above the level of the exposed inferior hypogastric plexus; and iii). extended pelvic/periaortic lymph node dissection preserving the superior hypogastric plexus. Since July 1998 we have studied prospectively the outcome in @entity0 treated with @entity4 for cervical @entity3 FIGO stages IB, IIA, and selected IIB. By July 2002, 71 @entity0 with @entity1 stages pT1b1 (n = 48), pT1b2 (n = 8), pT2a (n = 3), pT2b (n = 12) had undergone @entity4 without adjuvant radiation. Fifty-four percent of the @entity0 exhibited histopathologic high risk factors. At a median observation period of 30 months (9-57 months) two @entity0 relapsed locally, two @entity0 developed pelvic and distant recurrences and two @entity0 only distant recurrences. Three @entity0 died from their disease. Grade 1 and 2 complications occurred in 20 @entity0 , no @entity0 had grade 3 or 4 complications. No severe long-term impairment of pelvic visceral functions related to @entity2 was detected. Based on these preliminary results, we believe @entity4 achieves a promising therapeutic index by providing a high probability of locoregional control at minimal short and long-term morbidity.

title: XXXX : high resolution nerve-sparing radical hysterectomy based on developmentally defined surgical anatomy.

answer: @entity4


abstract: Sigmoidal mean arterial pressure (MAP)-heart rate (HR) curves were obtained in two genetically related strains of @entity0 (groups I and II). We examined vagal (V) and sympathetic (S) effects on HR using perivascular cuffs and vasoactive drugs to alter MAP, and we studied the effects of intravenous @entity3 , which affected only I. With the cuff method, both V and S components of gain were much greater in I than in II, and @entity3 greatly reduced the difference. With the drug method, gain was similar in I and II and unaffected by @entity3 . With both methods, the V component of HR range between plateaus was greater in I than in II because of more pronounced @entity2 at the lower plateau; @entity3 eliminated the latter difference when the reflex was drug induced but not when it was cuff induced. The S component of HR range was similar in I and II; with both methods, the @entity1 plateau was reduced by @entity3 . The cuff method alters cardiac load more than the drug method, leading to engagement of different groups of afferents for a given change in MAP (delta MAP). We have derived an input-output model, which suggests that with the drug method, gain is almost entirely determined by the input from the arterial baroreceptors, accounting for the minimal difference between I and II. With the cuff method, gain is determined by a nonlinear interaction involving the arterial and nonarterial baroreceptors, which accentuates the response. The opiate mechanism is associated with the nonarterial baroreceptor input and has amplifying properties, which account for the difference in gain between I and II. The two methods and @entity3 provide a novel way of differentiating the effector patterns of the reflex; @entity3 serves as a marker of activity in a particular pathway.

title: Differentiation of cardiac baroreflex properties by cuff and drug methods in two XXXX strains.

answer: @entity0


abstract: @entity0 with @entity1 are at high risk for recurrent disease and often undergo multiple operations. Our aims were to evaluate surgical management and outcome of @entity0 with @entity1 who develop @entity6 ( @entity6 ) and to identify factors leading to this complication. We reviewed the records of 170 adult @entity0 with @entity6 evaluated over a 20-year period. Thirty (18%) had @entity1 . @entity6 was defined as an intestinal remnant less than 180 cm with associated malabsorption. There were 20 @entity0 and 10 @entity0 ranging in age from 18 to 62 years. Eighteen (60%) presented initially with @entity3 , seven (23%) with @entity4 , and five (17%) with small intestinal disease. The interval from initial diagnosis to development of @entity6 ranged from 2 to 32 years, with 21 @entity0 (71%) having an interval greater than 15 years. The number of resections leading to @entity6 varied from 2 to 12 with 24 @entity0 (80%) having four or fewer resections. Nineteen @entity0 (63%) had an ostomy. Small intestinal remnant length was less than 60 cm in 10 @entity0 , 60 to 120 cm in six @entity0 , and greater than 120 cm in 14 @entity0 . Only one @entity0 underwent stricturoplasty before developing @entity6 . Five @entity0 were initially diagnosed as having @entity2 and underwent a pouch procedure, which was subsequently resected. Twenty @entity0 (67%) required parenteral nutrition. Three @entity0 have undergone reversed intestinal segment to slow intestinal transit. Two @entity0 underwent intestinal transplantation. Two @entity0 have died: one from parenteral nutrition-related @entity5 and the other after intestinal transplantation. @entity1 remains a common cause of @entity6 . Aggressive resectional therapy, surgical complications, and errors in initial diagnosis contribute to development of @entity6 in these @entity0 . Selected @entity0 are candidates for surgical therapy for @entity6 .

title: @entity6 and XXXX .

answer: @entity1


abstract: @entity0 with @entity1 are at high risk for recurrent disease and often undergo multiple operations. Our aims were to evaluate surgical management and outcome of @entity0 with @entity1 who develop @entity6 ( @entity6 ) and to identify factors leading to this complication. We reviewed the records of 170 adult @entity0 with @entity6 evaluated over a 20-year period. Thirty (18%) had @entity1 . @entity6 was defined as an intestinal remnant less than 180 cm with associated malabsorption. There were 20 @entity0 and 10 @entity0 ranging in age from 18 to 62 years. Eighteen (60%) presented initially with @entity3 , seven (23%) with @entity4 , and five (17%) with small intestinal disease. The interval from initial diagnosis to development of @entity6 ranged from 2 to 32 years, with 21 @entity0 (71%) having an interval greater than 15 years. The number of resections leading to @entity6 varied from 2 to 12 with 24 @entity0 (80%) having four or fewer resections. Nineteen @entity0 (63%) had an ostomy. Small intestinal remnant length was less than 60 cm in 10 @entity0 , 60 to 120 cm in six @entity0 , and greater than 120 cm in 14 @entity0 . Only one @entity0 underwent stricturoplasty before developing @entity6 . Five @entity0 were initially diagnosed as having @entity2 and underwent a pouch procedure, which was subsequently resected. Twenty @entity0 (67%) required parenteral nutrition. Three @entity0 have undergone reversed intestinal segment to slow intestinal transit. Two @entity0 underwent intestinal transplantation. Two @entity0 have died: one from parenteral nutrition-related @entity5 and the other after intestinal transplantation. @entity1 remains a common cause of @entity6 . Aggressive resectional therapy, surgical complications, and errors in initial diagnosis contribute to development of @entity6 in these @entity0 . Selected @entity0 are candidates for surgical therapy for @entity6 .

title: XXXX and @entity1 .

answer: @entity6


abstract: The potential short-term arrhythmogenic role of catheter-mediated electrical ablation was studied in 61 @entity0 of mean age 44 years (range 15-80 years) who underwent this procedure for @entity5 (36 @entity0 ) or @entity4 ( @entity4 , 25 @entity0 ). Continuous ECG monitoring was pursued during the 24 hours that preceded and followed ablation. Only bursts of 3 consecutive beats or more were considered significant. Recordings were performed with either a Hewlet Packard 78720 A @entity2 recorder or a Holter readout system (Oxford Medilog 2, Marquette). In 36 @entity0 with an accessory conduction pathway the 160 J were delivered at the annulus fibrosus cordis. Post-ablation recordings showed: @entity4 bursts in 16 @entity0 (17%); the bursts disappeared in every case before 3 days; in 3 @entity0 the electrogram at the site of ablation was predominantly ventricular (p less than 0.05); frequent or subintrant attacks of reciprocal orthodromic rhythm (RR); in 3 cases RR began on simple variations of heart rate; it reflected a loss of the anterograde conduction hidden in the accessory pathway and required a second ablation; in 1 case RR initiated by @entity4 bursts revealed the presence of a second accessory pathway; @entity1 , spontaneously resolved, in 4 @entity0 (11%). No @entity3 was recorded. In @entity0 with @entity4 ablation was delivered in the right ventricle (160 J, 9 @entity0 ) or in the left ventricle (240 J, 16 @entity0 ). The effects of ablation could only be interpreted in 21 @entity0 who underwent 25 ablations.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Incidence of short-term XXXX after endocavitary fulguration].

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to retrospectively evaluate, in a series of 50 consecutive @entity0 , the feasibility, morbidity, and survival outcome of the laparoscopic radical hysterectomy for @entity6 . METHODS: Fifty @entity0 with @entity1 were operated on by laparoscopic radical hysterectomy between 1993 and 2001 at two @entity2 centers. @entity0 in a @entity3 with a @entity6 less than 4 cm and a body mass index up to 29 were eligible. Thirty-one @entity0 had prior brachytherapy. RESULTS: The median overall operative time was 258 min. The mean number of harvested pelvic external iliac nodes was 13.22 per @entity0 . The median postoperative hospital stay was 7.5 days. Two @entity0 had major @entity4 ; one had a @entity4 and one a @entity5 . The median follow-up was 44 months. The overall 5-year survival rate of FIGO stage @entity8 and @entity7 @entity0 was 96%. CONCLUSION: Our results demonstrate that radical hysterectomy can be performed by laparoscopy in stage @entity7 or less advanced node negative @entity2 @entity0 without compromising survival. Prior brachytherapy did not affect the feasibility of this radical procedure.

title: Laparoscopic radical hysterectomy for XXXX : 8-year experience of a pilot study.

answer: @entity1


abstract: We present our clinical experience with 37 @entity0 presenting with @entity6 who, between 1980 and 1986, underwent subendocardial resection, guided by per-operative mapping in 34 cases. An @entity3 of the left ventricle was present in 23 @entity0 (62%), and an @entity7 area in the remaining 14 @entity0 . In every case the cause of @entity6 was an @entity2 . Prior to surgery, the global isotopic ejection fraction was 27 +/- 11% and the left ventricular end-diastolic pressure was 21 +/- 8 mmHg. The most common site of origin of the @entity4 was the septum (26 cases, 77%). The mean area of resection was 26 +/- 16 cm2. Resection of a @entity3 was also performed in 23 cases, and 22 @entity0 underwent coronary bypass. There were 4 early @entity1 (operative mortality rate : 10.8%) and 4 late @entity1 . The actuarial survival rate was 89 +/- 5% at 6 months and 72 +/- 9% at 24 months. One-half of the @entity1 was due to recurrence of the @entity6 . A post-operative electrophysiological study conducted in 30 @entity0 proved negative in 28 (93%). Altogether, there were 6 immediate or late failures (16.2%) after a mean follow-up period of 18 months. The probability of a relapse-free, medication-free life or @entity5 was 86 +/- 6% after 6 months and 82 +/- 7% after 24 months. The quality of life of the survivors war remarkable, since 86% of them (25/29 @entity0 ) remained in functional class 1 or 2 after surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Surgical treatment of XXXX ].

answer: @entity6


abstract: OBJECTIVE: The objective was to report a series of infertility therapy outcomes following conservative management of @entity4 with atypia. METHODS: A retrospective review of the University of Iowa assisted reproductive technology database was performed. All @entity0 presenting with International Federation of Obstetrics and Gynecology (FIGO) grade I uterine @entity1 with atypia were assessed for type and duration of medical management, initial, interim treatment, and preinfertility treatment endometrial biopsy (BX) findings. Assessment of infertility treatment outcomes and postinfertility endometrial biopsy findings were performed. All of the pathology samples were re-reviewed at the Gynecologic Oncology Tumor Board to confirm the diagnosis by a pathologist with a particular expertise in gynecologic pathology. RESULTS: Four infertile @entity0 , three nulligravid and one primigravid, were evaluated with the diagnosis of FIGO grade 1 @entity4 with atypia desiring to preserve fertility. Two @entity0 with FIGO grade 1 @entity2 were successfully treated with high-dose progestational agents resulting in normal proliferative endometrium. In addition, both @entity0 with @entity3 with atypia were successfully treated with @entity5 and/or ovulation induction. Successful pregnancy outcomes were achieved for three of the four @entity0 with assisted reproductive technology. A total of five successful pregnancies and eight healthy live-born @entity0 were achieved among three @entity0 . One of the four @entity0 was unable to conceive despite three cycles of in vitro fertilization. Hysterectomy was performed for recurrent @entity3 with atypia. In our series, we found it can take 3-10 months (mean, 6.25 months; median, 6 months) to obtain benign endometrium preceding infertility therapy. CONCLUSION: This report demonstrates that conservative management of well-differentiated @entity4 with atypia followed by aggressive assisted reproduction is an option to highly motivated and carefully selected @entity0 .

title: Implementation of assisted reproductive technologies following conservative management of FIGO grade I XXXX with atypia.

answer: @entity4


abstract: OBJECTIVE: The objective was to identify demographic, clinical, and provider characteristics that might influence @entity1 survival in a cohort of Northern California @entity0 using a population-based @entity1 registry. METHODS: We used California @entity1 Registry data to evaluate survival in 1051 Northern California @entity0 who were diagnosed with @entity2 between 1994 and 1996 and underwent a surgical procedure for their @entity1 . Chemotherapy data from the @entity1 registry were supplemented with a physician survey and medical record review. Database linkages with census and hospital discharge data provided socioeconomic and comorbidity measures. Kaplan-Meier method was used to generate survival curves and multivariate Cox proportional hazard models were used to evaluate the effect of different factors on survival. RESULTS: Crude 5-year survival was 82, 57, 28, and 10% for @entity0 with FIGO stage IC, II, III, and IV disease, respectively. Adverse survival was most strongly influenced by advanced stages III and IV with a hazards ratio ranging from 8 to 11.8 compared to stage @entity3 . Multivariate analysis also identified other adverse factors including high grade and other adverse histologies, age over 45, and rural location. Chemotherapy decreased the risk of @entity4 by 50% if the @entity0 had @entity1 . Medical comorbidity increased the risk of @entity4 by 40%. Survival was not influenced by race/ethnicity, socioeconomic status, physician specialty, or hospital characteristics. CONCLUSION: Advanced age remains an adverse prognostic factor even after adjustment for treatment and comorbidity factors. These results also suggest that there may be important regional differences in @entity2 survival.

title: Survival of Californian @entity0 with XXXX , 1994-1996: a population-based study.

answer: @entity2


abstract: OBJECTIVE: The objective was to identify demographic, clinical, and provider characteristics that might influence @entity1 survival in a cohort of Northern California @entity0 using a population-based @entity1 registry. METHODS: We used California @entity1 Registry data to evaluate survival in 1051 Northern California @entity0 who were diagnosed with @entity2 between 1994 and 1996 and underwent a surgical procedure for their @entity1 . Chemotherapy data from the @entity1 registry were supplemented with a physician survey and medical record review. Database linkages with census and hospital discharge data provided socioeconomic and comorbidity measures. Kaplan-Meier method was used to generate survival curves and multivariate Cox proportional hazard models were used to evaluate the effect of different factors on survival. RESULTS: Crude 5-year survival was 82, 57, 28, and 10% for @entity0 with FIGO stage IC, II, III, and IV disease, respectively. Adverse survival was most strongly influenced by advanced stages III and IV with a hazards ratio ranging from 8 to 11.8 compared to stage @entity3 . Multivariate analysis also identified other adverse factors including high grade and other adverse histologies, age over 45, and rural location. Chemotherapy decreased the risk of @entity4 by 50% if the @entity0 had @entity1 . Medical comorbidity increased the risk of @entity4 by 40%. Survival was not influenced by race/ethnicity, socioeconomic status, physician specialty, or hospital characteristics. CONCLUSION: Advanced age remains an adverse prognostic factor even after adjustment for treatment and comorbidity factors. These results also suggest that there may be important regional differences in @entity2 survival.

title: Survival of Californian XXXX with @entity2 , 1994-1996: a population-based study.

answer: @entity0


abstract: OBJECTIVE: When @entity9 is associated with other @entity3 , diagnosis, prognosis and the treatment strategies are affected. @entity8 may occur in some pathological settings that affect mitral apparatus. We investigated the incidence of @entity3 including @entity8 that accompany @entity9 and assessed the relation between echocardiographic measures. METHODS: Two hundred and one @entity0 (31 male, 170 female) between 16 and 72 years of age (mean age 40.9+/-11.4 years) with @entity9 were included in the study. @entity0 were divided into three groups according to the mitral valve area obtained by echocardiography using planimetric method as Group I (MVA<1.1 cm(2)), Group II ( @entity11 .1-1.5 cm(2)) and Group III ( @entity11 .5 cm2). RESULTS: @entity9 with @entity2 , @entity1 , @entity4 , combined @entity6 , @entity7 and @entity10 were found in 117 (58.2%), 84 (41.8%), 18 (9%), 9 (4.5%), 62 (30.8%) and 6 (3%) @entity0 , respectively. Twenty- three @entity0 (11.4%) had @entity8 in only anterior leaflet. Nobody of @entity0 had @entity8 . Age, gender, rhythm, degree of @entity5 , degree of mitral and aortic regurgitations, mean pressure gradient, left atrial diameter, ejection fraction and valve score did not differ in @entity0 with and without @entity8 . CONCLUSION: Our study has shown that @entity3 including @entity8 frequently accompany @entity9 and the incidence of @entity8 in @entity0 with @entity9 is high.

title: [Echocardiographic evaluation of associated XXXX in @entity9 ].

answer: @entity3


abstract: OBJECTIVE: When @entity9 is associated with other @entity3 , diagnosis, prognosis and the treatment strategies are affected. @entity8 may occur in some pathological settings that affect mitral apparatus. We investigated the incidence of @entity3 including @entity8 that accompany @entity9 and assessed the relation between echocardiographic measures. METHODS: Two hundred and one @entity0 (31 male, 170 female) between 16 and 72 years of age (mean age 40.9+/-11.4 years) with @entity9 were included in the study. @entity0 were divided into three groups according to the mitral valve area obtained by echocardiography using planimetric method as Group I (MVA<1.1 cm(2)), Group II ( @entity11 .1-1.5 cm(2)) and Group III ( @entity11 .5 cm2). RESULTS: @entity9 with @entity2 , @entity1 , @entity4 , combined @entity6 , @entity7 and @entity10 were found in 117 (58.2%), 84 (41.8%), 18 (9%), 9 (4.5%), 62 (30.8%) and 6 (3%) @entity0 , respectively. Twenty- three @entity0 (11.4%) had @entity8 in only anterior leaflet. Nobody of @entity0 had @entity8 . Age, gender, rhythm, degree of @entity5 , degree of mitral and aortic regurgitations, mean pressure gradient, left atrial diameter, ejection fraction and valve score did not differ in @entity0 with and without @entity8 . CONCLUSION: Our study has shown that @entity3 including @entity8 frequently accompany @entity9 and the incidence of @entity8 in @entity0 with @entity9 is high.

title: [Echocardiographic evaluation of associated @entity3 in XXXX ].

answer: @entity9


abstract: The effect of acute physical exercise on insulin sensitivity and responsiveness of @entity2 uptake and hepatic @entity2 production was studied. Seven untrained @entity0 were subjected to four sequential euglycemic hyperinsulinemic clamps after rest (R), immediately after exercise (E), as well as 48 h after 60 min of 150 W ergometer exercise (ER). Insulin-mediated @entity2 uptake was higher on E and ER days compared with R days. Apparent Km decreased after exercise (52 +/- 3 R vs. 43 +/- 4 E and 40 +/- 3 ER microU/ml, means +/- SE) and Vmax increased (9.5 +/- 0.8 R vs. 10.9 +/- 0.7 E and 10.7 +/- 0.8 ER mg.min-1.kg-1). @entity2 oxidation increased with the increasing insulin infusion rate, and maximal @entity2 oxidation rate was lower on E days compared with R days. The maximal conversion rate of @entity2 to glycogen was higher on E and ER days (8.0 +/- 0.3 and 7.2 +/- 0.2, respectively) than on R days (5.7 +/- 0.6 mg.min-1 kg-1). Muscle glycogen synthase I activity was higher immediately after exercise and remained higher for the next 48 h. No change in any glucoregulatory hormone or metabolite could explain the @entity1 seen after exercise. In additional experiments (n = 3), no remaining effect existed 5 days after exercise. Both insulin and exercise suppressed the pancreatic secretion of insulin and @entity3 . The conclusions drawn are that prolonged moderate exercise increases insulin action on @entity2 uptake in @entity0 by reducing apparent Km and increasing Vmax. This effect lasts 48 h but not 5 days. The @entity1 may be related to an exercise-induced increase in glycogen synthase activity.

title: Effect of physical exercise on sensitivity and responsiveness to insulin in XXXX .

answer: @entity0


abstract: BACKGROUND: Pathology reports have shown that @entity5 in @entity2 ( @entity2 ) are equal to or greater than those in @entity3 ( @entity3 ). We hypothesized that @entity0 with @entity2 would have @entity1 that were similar to or greater than those of @entity0 with @entity3 . OBJECTIVE: To determine in vivo cortical @entity6 ( @entity6 ) activity in healthy control subjects and in @entity0 with mild @entity3 , @entity2 , and @entity2 without @entity4 using @entity6 positron emission tomography. SETTING: University and Veterans' Administration medical center. Design and @entity0 Group comparison design of @entity0 with @entity3 (n = 12), @entity2 (n = 14), and @entity2 without @entity4 (n = 11), and controls (n = 10) who underwent @entity6 imaging between July 1, 2000, and January 31, 2003. @entity0 with @entity3 and @entity2 had approximately equal @entity4 severity. MAIN OUTCOME MEASURES: Cerebral @entity6 activity. RESULTS: Compared with controls, mean cortical @entity6 activity was lowest in @entity0 with @entity2 (-20.0%), followed by @entity0 with @entity2 without @entity4 (-12.9%; P<.001). Mean cortical @entity6 activity was relatively preserved in @entity0 with @entity3 (-9.1%), except for regionally selective involvement of the lateral temporal cortex (-15%; P<.001). CONCLUSION: Reduced cortical @entity6 activity is more characteristic of @entity0 with @entity2 than of @entity0 with mild @entity3 .

title: Cortical cholinergic function is more severely affected in @entity2 than in XXXX : an in vivo positron emission tomographic study.

answer: @entity3


abstract: BACKGROUND: Pathology reports have shown that @entity5 in @entity2 ( @entity2 ) are equal to or greater than those in @entity3 ( @entity3 ). We hypothesized that @entity0 with @entity2 would have @entity1 that were similar to or greater than those of @entity0 with @entity3 . OBJECTIVE: To determine in vivo cortical @entity6 ( @entity6 ) activity in healthy control subjects and in @entity0 with mild @entity3 , @entity2 , and @entity2 without @entity4 using @entity6 positron emission tomography. SETTING: University and Veterans' Administration medical center. Design and @entity0 Group comparison design of @entity0 with @entity3 (n = 12), @entity2 (n = 14), and @entity2 without @entity4 (n = 11), and controls (n = 10) who underwent @entity6 imaging between July 1, 2000, and January 31, 2003. @entity0 with @entity3 and @entity2 had approximately equal @entity4 severity. MAIN OUTCOME MEASURES: Cerebral @entity6 activity. RESULTS: Compared with controls, mean cortical @entity6 activity was lowest in @entity0 with @entity2 (-20.0%), followed by @entity0 with @entity2 without @entity4 (-12.9%; P<.001). Mean cortical @entity6 activity was relatively preserved in @entity0 with @entity3 (-9.1%), except for regionally selective involvement of the lateral temporal cortex (-15%; P<.001). CONCLUSION: Reduced cortical @entity6 activity is more characteristic of @entity0 with @entity2 than of @entity0 with mild @entity3 .

title: Cortical cholinergic function is more severely affected in XXXX than in @entity3 : an in vivo positron emission tomographic study.

answer: @entity2


abstract: OBJECTIVE: To determine safety and efficacy of monotherapy with etanercept. DESIGN: Randomized, double-blind, placebo-controlled, multicenter study. SETTING: Outpatient, ambulatory; private practice and university dermatology research centers. @entity0 : @entity0 aged at least 18 years, with @entity1 involving 10% or more of body surface area; 148 were screened and 112 were randomly assigned to treatment groups and received study drug. INTERVENTIONS: @entity0 received placebo or etanercept, 25 mg, subcutaneously twice a week for 24 weeks. Other @entity1 therapies were limited during the study. MAIN OUTCOME MEASURES: Safety measurements included tracking of adverse events and laboratory values. Efficacy was evaluated using the Psoriasis Area and Severity Index (PASI); the primary end point was a 75% improvement in PASI. Other efficacy measurements included @entity0 and physician global assessments and quality-of-life measures. RESULTS: After 12 weeks of treatment, 17 (30%) of the 57 etanercept-treated @entity0 and 1 (2%) of the 55 placebo-treated @entity0 had achieved PASI 75%, and after 24 weeks, 32 (56%) of etanercept-treated @entity0 and 3 (5%) of placebo-treated @entity0 had reached this level (P<.001 for both time points). By 24 weeks, @entity1 was clear or minimal by physician's global assessment in more than 50% of @entity0 who received etanercept. Treatment failure (PASI response <50) occurred in 23% of @entity0 at week 24. All other measures confirmed the efficacy of etanercept. Adverse events were similar among etanercept and placebo groups. CONCLUSION: Etanercept monotherapy provided significant benefit to @entity0 with @entity1 and had a favorable safety profile.

title: A randomized trial of etanercept as monotherapy for XXXX .

answer: @entity1


abstract: OBJECTIVE: To determine factors associated with remission of @entity1 recurrent @entity2 (JORRP). DESIGN: Longitudinal study. SETTING: Twenty-two tertiary care centers located across the United States. STUDY @entity0 AND METHODS: The study included 165 @entity0 diagnosed as having JORRP between January 1, 1997, and December 31, 2000. Kaplan-Meier curves and Cox proportional hazards models were used to determine associations between predictors and remission. INTERVENTIONS: Surgical excision and drug therapy. MAIN OUTCOME MEASURES: Remission of JORRP, defined as no surgical procedures for at least 1 year, as associated with age at diagnosis, drug therapy in the first year after diagnosis, number of surgical procedures in the first year after diagnosis, and number of anatomical sites of disease at diagnosis. Demographic factors (sex and race) and Medicaid status were also evaluated. RESULTS: Older age at diagnosis was positively associated with remission of JORRP (hazards ratio for every increase of 1 year in age, 1.13; 95% confidence interval, 1.03-1.23). CONCLUSIONS: Younger @entity0 were found to have persistent disease and often underwent an increased number of surgical procedures in the first year after diagnosis of JORRP. Sex and race were not important factors in determining remission.

title: Predictors of remission in XXXX recurrent @entity2 .

answer: @entity1


abstract: OBJECTIVE: To determine factors associated with remission of @entity1 recurrent @entity2 (JORRP). DESIGN: Longitudinal study. SETTING: Twenty-two tertiary care centers located across the United States. STUDY @entity0 AND METHODS: The study included 165 @entity0 diagnosed as having JORRP between January 1, 1997, and December 31, 2000. Kaplan-Meier curves and Cox proportional hazards models were used to determine associations between predictors and remission. INTERVENTIONS: Surgical excision and drug therapy. MAIN OUTCOME MEASURES: Remission of JORRP, defined as no surgical procedures for at least 1 year, as associated with age at diagnosis, drug therapy in the first year after diagnosis, number of surgical procedures in the first year after diagnosis, and number of anatomical sites of disease at diagnosis. Demographic factors (sex and race) and Medicaid status were also evaluated. RESULTS: Older age at diagnosis was positively associated with remission of JORRP (hazards ratio for every increase of 1 year in age, 1.13; 95% confidence interval, 1.03-1.23). CONCLUSIONS: Younger @entity0 were found to have persistent disease and often underwent an increased number of surgical procedures in the first year after diagnosis of JORRP. Sex and race were not important factors in determining remission.

title: Predictors of remission in @entity1 recurrent XXXX .

answer: @entity2