abstract: @entity3 is common after repair of tetralogy of Fallot (TF) and may cause @entity4 . To explore the mechanisms, ambulatory electrocardiographic monitoring and electrophysiologic studies were undertaken, without the use of provocative tests, in 22 @entity0 5 to 24 years (mean 13) after repair. His-Purkinje and right ventricular (RV) apical activation times were measured to assess conduction. Endocardial mapping of the right ventricle was performed, with additional recordings from the left ventricle in 10 @entity0 , to detect abnormalities of local depolarization and repolarization. Local RV electrograms were fractionated or delayed in 12 @entity0 (55%) at 1 or more RV sites (septum in 7 @entity0 , outflow in 7, free wall in 2 and apex 1 @entity0 ), reflecting disordered depolarization, but left ventricular recordings were normal in all. @entity3 out of hospital was more common (p less than 0.05) and more severe (p less than 0.01) in the @entity0 with @entity2 than in those with normal electrographic findings. In contrast, there was no association between @entity3 and conduction disturbances. Abnormalities of RV repolarization, consisting of low-frequency signals after the T wave, were observed in 17 @entity0 (77%), but were not associated with @entity3 . Thus, @entity3 during daily life was associated with fractionated depolarization at multiple sites in the right ventricle. This suggests that there are widespread areas of RV @entity1 that provide substrates for @entity5 .

title: @entity2 of right ventricular depolarization after repair of tetralogy of Fallot: a basis for XXXX .

answer: @entity3


abstract: We correlated levels of circulating @entity2 (NE) and @entity3 (Epi) induced by 1) infusions, 2) treadmill exercise, and 3) @entity1 with left ventricular (LV) function in conscious @entity0 instrumented for the measurement of LV and arterial pressures, LV diameter, and calculations of indexes of myocardial contractility. With infusions of NE, significant hemodynamic changes were observed only when plasma levels of NE exceeded 1,000 pg/ml. While statistically significant, the increase in rate of rise of LV pressure (LV dP/dt) at these levels was relatively slight, i.e., 8 +/- 2.3%. With further increases in @entity4 (greater than 1,000 pg/ml) good correlations were observed with increases in arterial pressure and myocardial contractility. Similar results occurred with infusions of Epi. Moderate treadmill exercise doubled LV dP/dt, while NE and Epi rose by only 563 +/- 128 and 292 +/- 50 pg/ml, respectively. @entity1 (30 ml/kg) decreased all indexes of contractility but increased plasma NE by 1,108 +/- 206 pg/ml and Epi by 1,475 +/- 266 pg/ml. Despite arterial NE and Epi levels 10-20 times those during exercise, infusions were unable to reproduce the peak changes in contractility seen with exercise. Infusions of NE or Epi to equal the plasma levels during exercise increased contractility by only 5-10%. In view of the marked disparity between levels of circulating @entity4 and LV function during exercise, @entity1 , and @entity5 infusion, we conclude that circulating @entity4 do not adequately reflect the degree of inotropic stimulation to the myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Correlation between cardiac performance and plasma XXXX levels in conscious @entity0 .

answer: @entity5


abstract: We correlated levels of circulating @entity2 (NE) and @entity3 (Epi) induced by 1) infusions, 2) treadmill exercise, and 3) @entity1 with left ventricular (LV) function in conscious @entity0 instrumented for the measurement of LV and arterial pressures, LV diameter, and calculations of indexes of myocardial contractility. With infusions of NE, significant hemodynamic changes were observed only when plasma levels of NE exceeded 1,000 pg/ml. While statistically significant, the increase in rate of rise of LV pressure (LV dP/dt) at these levels was relatively slight, i.e., 8 +/- 2.3%. With further increases in @entity4 (greater than 1,000 pg/ml) good correlations were observed with increases in arterial pressure and myocardial contractility. Similar results occurred with infusions of Epi. Moderate treadmill exercise doubled LV dP/dt, while NE and Epi rose by only 563 +/- 128 and 292 +/- 50 pg/ml, respectively. @entity1 (30 ml/kg) decreased all indexes of contractility but increased plasma NE by 1,108 +/- 206 pg/ml and Epi by 1,475 +/- 266 pg/ml. Despite arterial NE and Epi levels 10-20 times those during exercise, infusions were unable to reproduce the peak changes in contractility seen with exercise. Infusions of NE or Epi to equal the plasma levels during exercise increased contractility by only 5-10%. In view of the marked disparity between levels of circulating @entity4 and LV function during exercise, @entity1 , and @entity5 infusion, we conclude that circulating @entity4 do not adequately reflect the degree of inotropic stimulation to the myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Correlation between cardiac performance and plasma @entity5 levels in conscious XXXX .

answer: @entity0


abstract: Ischemic @entity3 were produced in 40 of 47 anesthetized mongrel @entity1 by high ligation of the left anterior descending coronary artery. @entity3 were treated with a single iv bolus of 20, 40, 80, or 120 mg of @entity4 (L) in order to determine the dose at which approximately 50% of animals had an antidysrhythmic response. Cardiac output and @entity2 ( @entity2 ) were measured by using radionuclide labeled microspheres. @entity4 concentration [( L]) was measured from samples of arterial and venous blood and normal and @entity0 . All @entity1 treated with 40, 80, or 120 mg of L had an antidysrhythmic effect. However, with 20 mg of L the @entity3 persisted in 12 and resolved in 14. With 20 mg of L, @entity0 myocardial [L] was greater in @entity1 with an antidysrhythmic effect than in those with persistent @entity3 (1.14 +/- 0.12 vs. 0.76 +/- 0.04 micrograms X g-1), but no difference was seen for arterial, venous, and normal myocardial [L]. Ischemic @entity2 was higher in the @entity1 that had an antidysrhythmic effect than in those that did not, 9.8 +/- 1.5 versus 6.9 +/- 1.3% of normal. With 20 mg of L, [L] in @entity0 correlated well with @entity0 @entity2 . The antidysrhythmic response to L had a threshold at a tissue concentration of greater than or equal to 1.0 microgram X g-1 (chi-square = 8.55, P less than 0.005). For this model, the [L] in @entity0 during acute @entity0 correlates with the antidysrhythmic response to L, while the concentration in normal myocardium or blood does not.

title: Regional myocardial XXXX concentration determines the antidysrhythmic effect in @entity1 after coronary artery occlusion.

answer: @entity4


abstract: Ischemic @entity3 were produced in 40 of 47 anesthetized mongrel @entity1 by high ligation of the left anterior descending coronary artery. @entity3 were treated with a single iv bolus of 20, 40, 80, or 120 mg of @entity4 (L) in order to determine the dose at which approximately 50% of animals had an antidysrhythmic response. Cardiac output and @entity2 ( @entity2 ) were measured by using radionuclide labeled microspheres. @entity4 concentration [( L]) was measured from samples of arterial and venous blood and normal and @entity0 . All @entity1 treated with 40, 80, or 120 mg of L had an antidysrhythmic effect. However, with 20 mg of L the @entity3 persisted in 12 and resolved in 14. With 20 mg of L, @entity0 myocardial [L] was greater in @entity1 with an antidysrhythmic effect than in those with persistent @entity3 (1.14 +/- 0.12 vs. 0.76 +/- 0.04 micrograms X g-1), but no difference was seen for arterial, venous, and normal myocardial [L]. Ischemic @entity2 was higher in the @entity1 that had an antidysrhythmic effect than in those that did not, 9.8 +/- 1.5 versus 6.9 +/- 1.3% of normal. With 20 mg of L, [L] in @entity0 correlated well with @entity0 @entity2 . The antidysrhythmic response to L had a threshold at a tissue concentration of greater than or equal to 1.0 microgram X g-1 (chi-square = 8.55, P less than 0.005). For this model, the [L] in @entity0 during acute @entity0 correlates with the antidysrhythmic response to L, while the concentration in normal myocardium or blood does not.

title: Regional myocardial @entity4 concentration determines the antidysrhythmic effect in XXXX after coronary artery occlusion.

answer: @entity1


abstract: A retrospective study of 30 @entity0 treated primarily with surgery for @entity1 between 1965 and 1980 was conducted. There were 13 @entity0 and 17 adults in this series. Apparent total surgical removal was obtained in six @entity0 and eight adults; the remaining @entity0 had subtotal resection. Radiation therapy was used for salvage in five @entity0 and after complete cyst removal in one. The ten-year survival rate was 80% in @entity0 and 30% in adults. The five-year survival was ten of 11 @entity0 with @entity1 and seven (41%) of 17 @entity0 in the adult group. Seven of 13 @entity0 in the childhood group experienced surgically documented recurrence after first surgery. Seven of 17 @entity0 recurred after first surgery in the adult group. Four died of operative complications. Morbidity demonstrated by quality of survival was high in these @entity0 .

title: Analysis of treatment results in XXXX .

answer: @entity1


abstract: From 1957 through September, 1983, 35 @entity0 with @entity1 and @entity2 underwent operation. Two subgroups of @entity0 were recognized: minimally symptomatic (Group A, n = 21) and markedly symptomatic (Group B, n = 14). Group B @entity0 were symptomatic at an earlier age and were younger at operation. Ages ranged from 1 day to 42 years (mean = 7.8 +/- 7.4 SD). Repair consisted of closure of the @entity6 and relief of the right ventricle-pulmonary artery pressure gradient (nine @entity0 received a tissue valve). In five @entity0 , partial resection and/or plication of the @entity4 also was performed. Operative mortality was 4.8% in Group A and 35.7% in Group B. In up to 25 years of follow-up, there was one late death in Group A (an early case with complete @entity5 ); the remaining 19 @entity0 are asymptomatic. In Group B, there were four late deaths, three related to @entity7 . These results indicate @entity2 is tolerated well in minimally symptomatic @entity0 . For markedly symptomatic @entity0 , results may be improved if repair includes @entity3 and reduction of size and length of @entity4 .

title: Tetralogy of Fallot with XXXX . Early and late results of surgical treatment.

answer: @entity2


abstract: Ten cases of @entity2 , diagnosed, treated, and followed during the past 11 years, were reviewed and the @entity0 reexamined. Two were up to 3 years, two up to 5 years, and four up to 11 years after excision. The remaining two @entity0 were lost to follow-up. The 10 @entity0 included one male and nine females; six females were of childbearing age and three were postmenopausal. In four females the @entity2 was located near various surgical scars. In the one recurrent desmoid it was most probably related to both repeated traumatization of the abdominal wall due to pregnancies and hyperestrogenism. All the surgical margins of resection were microscopically involved by the process. An open liver biopsy, performed simultaneously with the excision of the recurrent desmoid, showed @entity4 compatible with hyperestrogenism. @entity1 and @entity3 receptors of this desmoid were negative. In the present series follow-up revealed, in contrast to general agreement, that in spite of incomplete excision, the recurrence rate was low. We suggest that the surgical approach to @entity2 could be less radical, except possibly for lesions in @entity0 with multiple causative factors.

title: XXXX --review and follow-up of ten cases.

answer: @entity2


abstract: OBJECTIVE: To study the safety of 3-4 @entity4 (DAP) in @entity0 with @entity3 and to examine its efficacy in reducing muscle fatigue and @entity1 and in improving objective parameters of muscle function. DESIGN: Assessments of safety included a questionnaire of symptoms, clinical examination, blood testing, and electrocardiography at each visit; efficacy was assessed by subjective scores of fatigue and @entity1 ; an Amyotrophic Lateral Sclerosis Functional Rating Scale and functional ability scores, including timed verbal scores; manual muscle testing; grip dynamometry; pulmonary function tests; timed functional tests; and electrophysiological studies. @entity0 : Thirteen subjects with @entity2 and seven subjects with only a lower motor neuron syndrome. MAIN OUTCOMES: Assess tolerability of DAP and determine if there was symptomatic improvement of muscle fatigue. SECONDARY OUTCOME: To determine the effects of DAP on objective parameters of muscle function. RESULTS: The drug was well tolerated with only four subjects reporting tingling of lips and fingers during the active drug period. The subjective scores for fatigue and @entity1 showed a mild improvement after 4 weeks on DAP compared with placebo. A significant benefit of DAP was also demonstrated in the timed verbal scores. CONCLUSION: 3-4 DAP appeared to be safe and produced subjective benefit in @entity3 . The drug could be added for symptomatic treatment in these diseases. Larger studies are necessary to demonstrate efficacy.

title: Effects of 3-4 diaminopyridine (DAP) in XXXX .

answer: @entity3


abstract: PURPOSE: To evaluate the clinical value of computed tomography angiography (CTA) in reducing the risk of @entity2 associated with mini-percutaneous nephrolithotomy (PCNL). MATERIALS AND METHODS: A total of 158 @entity0 with renal or ureter stones who had undergone mini-percutaneous nephrolithotomy were retrospectively enrolled into this study from May of 2011 to April of 2014. Group 1 (65 @entity0 ) underwent computed tomography angiography, and Group 2 (93 @entity0 ) underwent non-contrast CT. The clinical characteristics of the @entity0 and @entity2 were recorded. The hematologic complications (transfusion rate, and preoperative and postoperative hemoglobin values) were assessed. RESULTS: There were no statistically significant differences in age, body mass index(BMI), stone diameter, operative time, stone-free rate, and hospital stay between the 2 groups. In group 2, 1 @entity0 (1.1%) developed a @entity1 and was treated with embolus therapy. In addition, Group 2 showed significantly drop in hemoglobin (3.6 g/dL vs. 2.4 g/dL, respectively; P < 0.001) and more transfusions (9.7% vs. 1.5%, respectively; P < 0.05) compared with Group 1. CONCLUSION: The study showed that @entity0 who underwent computed tomography angiography prior to percutaneous nephrolithotomy had lower drop of hemoglobin and needed less transfusions. These findings may suggest that the use of computed tomography angiography may reduce the risk of bleeding during percutaneous nephrolithotomy.

title: Value of CT angiography in reducing the risk of XXXX associated with mini-percutaneous nephrolithotomy.

answer: @entity2


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a frequent chronic inflammatory skin disease typically characterized by recurrent painful, deep inflammatory nodules of the axillary, breast, groin and gluteal areas. European recommendations are mainly based on expert opinion. Drug treatments are heterogenous (e.g., antibiotics, @entity2 , @entity5 ) and lack consensus among expert centres. The most severe disease forms or those failing to respond to conventional drugs may be associated with worsened functional prognosis. Anti- @entity0 @entity1 factor a (anti- @entity3 ) drugs have been prescribed in these cases. The results of randomized controlled trials (RCTs) are discordant. Three RCTs concluded to the efficacy of adalimumab (ADA), and two others did not detect any difference between infliximab (IFX) or etanercept (ETA) and placebo. Finally, data from the literature and reported experiences do not conclude on the efficacy of anti- @entity3 drugs for @entity4 . This article is protected by copyright. All rights reserved.

title: Anti- XXXX therapy for hidradenitis suppurativa. Results from a national cohort study between 2000 and 2013.

answer: @entity3


abstract: BACKGROUND: The platelet storage lesion causes loss of function and viability over time. A new paradigm for platelet storage is desired to enable safer, more effective transfusions while reducing waste. We hypothesized that repletion of @entity4 , which is chelated by @entity3 anticoagulant, could reduce platelet storage lesion severity when given in conjunction with storage at a refrigerated temperature. METHODS: Apheresis platelet units were collected from healthy donors and stored at 22  C or 4  C. On Days 0, 2, 4, and 8, samples were collected for analyses of receptor-mediated aggregation, coagulation, adhesion to collagen under flow, and viability. In the first series, samples were given an acute dose of @entity2 before testing; in the second series, storage bags were supplemented with 0-, 3-, or 6-mM @entity2 . RESULTS: Acutely delivered @entity2 induced a more rapid coagulation time in apheresis platelets, further enhanced by storage at 4  C. Platelet adhesion to a collagen surface while exposed to arterial shear rates (920 s) was enhanced by @entity2 supplementation-acute @entity2 had a large effect on adhesion of fresh platelets, which diminished more rapidly in 22  C samples, while storage with @entity2 showed significant benefits even out to Day 4 at both temperatures. Although 4  C storage improves the longevity of @entity0 responses to agonists, @entity2 supplementation did not change those responses. CONCLUSION: Acute @entity2 reduces clot time likely through the transient increase of free @entity5 . Limited differences between platelet function in acute delivery of and storage with @entity2 diminish the possibility that @entity4 -induced metabolic inhibition of platelets synergizes with 4  C storage. Regardless, @entity1 supplementation to platelets is an exciting possibility in transfusion because the adhesion response of 22  C-stored platelets on Day 4 is significantly enhanced when stored with 6-mM @entity2 .

title: Both acute delivery of and storage with magnesium sulfate promote XXXX and coagulation function.

answer: @entity0


abstract: PURPOSE: The determination of the best therapeutic approach in extraperitoneal @entity2 @entity0 is very complex both in the neoadjuvant/adjuvant and the metastatic setting. We tried to identify and summarize the current methods of diagnosis, staging and treatment from a multidisciplinary approach. METHODS: Five sections can be indentified: diagnosis and staging; neoadjuvant treatment; adjuvant treatment; liver metastases treatment and local recurrence therapy Data were collected from international guidelines (NCCN) and MEDLINE search. The main aim was the identification of the beast diagnostic and therapeutic approach in extraperitoneal @entity2 @entity0 in case of local recurrence and @entity1 . RESULTS: Data from 2010 NCCN guidelines and 48 articles published in major international oncologic reviews were collected and evaluated from 1993 up to 2009. Three articles dealt with staging procedures, 24 dealt with neoadjuvant and adjuvant therapy; 18 were about with liver metastases and 3 about local recurrence treatment. CONCLUSIONS: The correct disease staging is necessary for pursuing the best therapeutic approach and it should involve different radiological techniques in order to evaluate the clinic @entity3 . Neoadjuvant treatment (chemo-radiotherapy) should be considered for stage II and stage III extraperitoneal @entity2 @entity0 , followed by post-operative adjuvant chemotherapy. @entity0 who underwent surgery and have a @entity2 , have to receive four months of adjuvant chemotherapy after surgical resection. Initial treatment options of asymptomatic @entity0 with resectable liver metases include systemic chemotherapy in' order to obtain downstaging of the @entity2 and liver metastase shrinking followed by resection. The treatment of local recurrence is mainly surgical. If not previously administered, radiotherapy represents an alternative therapeutic treatment.

title: [Extraperitoneal XXXX : chemo-radiotherapy treatments].

answer: @entity2


abstract: UNASSIGNED: BACKGROUND To provide a preliminary estimate of efficacy of @entity2 ( @entity2 ) when compared to no-intervention in @entity0 with chronic (>1 year) post- @entity3 @entity4 in order to plan an appropriately powered @entity1 ( @entity1 ).   MATERIAL AND METHODS We conducted a pilot single-blinded @entity1 .   24 @entity0 were randomized: 14 to @entity2 and 10 to no-intervention.   @entity2 groups received up to 4 hours/day of intervention for 10 consecutive business days (40 hours or therapy).   Outcomes were assessed within 1 week of intervention and at 1 and 12 weeks after intervention and included several linguistic measures and a measure of overall subjective communication abilities (mini-Communicative Abilities Log (mini-CAL)).   Clinicians treating @entity0 ( @entity2 group) did not communicate with other team members to maintain blinding and the testing team members were blinded to treatment group assignment.   RESULTS Overall, the results of this pilot @entity1 support the results of previous observational studies that @entity2 may lead to improvements in linguistic abilities.   At 12 weeks, the treatment group reported better subjective communication abilities (mini-CAL) than the no-intervention group (p=0.019).   Other measures trended towards better performance in the @entity2 group. CONCLUSIONS In this pilot @entity1 intensive language therapy led to an improvement in subjective language abilities.   The effects demonstrated allow the design of a definitive trial of @entity2 in @entity0 with a variety of post- @entity3 @entity4 types.   In addition, our experiences have identified important considerations for designing subsequent trial(s) of @entity2 or other interventions for post- @entity3 @entity4 .

title: Constraint-Induced XXXX Therapy for Treatment of Chronic Post- @entity3 @entity4 : A Randomized, Blinded, Controlled Pilot Trial.

answer: @entity4


abstract: UNASSIGNED: BACKGROUND To provide a preliminary estimate of efficacy of @entity2 ( @entity2 ) when compared to no-intervention in @entity0 with chronic (>1 year) post- @entity3 @entity4 in order to plan an appropriately powered @entity1 ( @entity1 ).   MATERIAL AND METHODS We conducted a pilot single-blinded @entity1 .   24 @entity0 were randomized: 14 to @entity2 and 10 to no-intervention.   @entity2 groups received up to 4 hours/day of intervention for 10 consecutive business days (40 hours or therapy).   Outcomes were assessed within 1 week of intervention and at 1 and 12 weeks after intervention and included several linguistic measures and a measure of overall subjective communication abilities (mini-Communicative Abilities Log (mini-CAL)).   Clinicians treating @entity0 ( @entity2 group) did not communicate with other team members to maintain blinding and the testing team members were blinded to treatment group assignment.   RESULTS Overall, the results of this pilot @entity1 support the results of previous observational studies that @entity2 may lead to improvements in linguistic abilities.   At 12 weeks, the treatment group reported better subjective communication abilities (mini-CAL) than the no-intervention group (p=0.019).   Other measures trended towards better performance in the @entity2 group. CONCLUSIONS In this pilot @entity1 intensive language therapy led to an improvement in subjective language abilities.   The effects demonstrated allow the design of a definitive trial of @entity2 in @entity0 with a variety of post- @entity3 @entity4 types.   In addition, our experiences have identified important considerations for designing subsequent trial(s) of @entity2 or other interventions for post- @entity3 @entity4 .

title: Constraint-Induced @entity4 Therapy for Treatment of Chronic Post- @entity3 XXXX : A Randomized, Blinded, Controlled Pilot Trial.

answer: @entity4


abstract: UNASSIGNED: BACKGROUND To provide a preliminary estimate of efficacy of @entity2 ( @entity2 ) when compared to no-intervention in @entity0 with chronic (>1 year) post- @entity3 @entity4 in order to plan an appropriately powered @entity1 ( @entity1 ).   MATERIAL AND METHODS We conducted a pilot single-blinded @entity1 .   24 @entity0 were randomized: 14 to @entity2 and 10 to no-intervention.   @entity2 groups received up to 4 hours/day of intervention for 10 consecutive business days (40 hours or therapy).   Outcomes were assessed within 1 week of intervention and at 1 and 12 weeks after intervention and included several linguistic measures and a measure of overall subjective communication abilities (mini-Communicative Abilities Log (mini-CAL)).   Clinicians treating @entity0 ( @entity2 group) did not communicate with other team members to maintain blinding and the testing team members were blinded to treatment group assignment.   RESULTS Overall, the results of this pilot @entity1 support the results of previous observational studies that @entity2 may lead to improvements in linguistic abilities.   At 12 weeks, the treatment group reported better subjective communication abilities (mini-CAL) than the no-intervention group (p=0.019).   Other measures trended towards better performance in the @entity2 group. CONCLUSIONS In this pilot @entity1 intensive language therapy led to an improvement in subjective language abilities.   The effects demonstrated allow the design of a definitive trial of @entity2 in @entity0 with a variety of post- @entity3 @entity4 types.   In addition, our experiences have identified important considerations for designing subsequent trial(s) of @entity2 or other interventions for post- @entity3 @entity4 .

title: Constraint-Induced @entity4 Therapy for Treatment of Chronic Post- XXXX @entity4 : A Randomized, Blinded, Controlled Pilot Trial.

answer: @entity3


abstract: UNASSIGNED: @entity1 ( @entity1 ) is associated with less uniform and slower walking in older adults. The effect of age and subclinical @entity2 (a potentially earlier phase of WM @entity4 ) on walking patterns and speed is less clear. This study examines the effect of age on the associations of regional microstructural WM integrity with walking variability and speed, independent of macrostructural @entity1 . This study involved 493 @entity0 (n   =   51 young; n   =   209 young-old; n   =   233 old-old) from the Baltimore Longitudinal Study of Aging. All completed a 400-meter walk test and underwent a concurrent brain MRI with diffusion tensor imaging. Microstructural WM integrity was measured as fractional anisotropy (FA). Walking variability was measured as trend-adjusted variation in time over ten 40-meter laps ( @entity5 time variation, LTV). Fast-paced walking speed was assessed as mean @entity5 time (MLT). Multiple linear regression models of FA predicting LTV and MLT were adjusted for age, sex, height, weight, and WM hyperintensities. Independent of WM hyperintensities, lower FA in the body of the corpus callosum was associated with higher LTV and longer MLT only in the young-old. Lower FA in superior longitudinal, @entity3 , the anterior limb of the internal capsule, and the anterior corona radiate was associated with longer MLT only in the young-old. While macrostructural @entity1 is known to predict more variable and slower walking in older adults, microstructural WM disruption is independently associated with more variable and slower fast-paced walking only in the young-old. Disrupted regional WM integrity may be a subclinical contributor to abnormal walking at an earlier phase of aging.

title: The effect of age and microstructural white matter integrity on XXXX time variation and fast-paced walking speed.

answer: @entity5


abstract: A neuropathological study was performed on two @entity0 with @entity3 , one male and one female, from different families. They both died at the age of 41 years. Both @entity0 showed increased excretion of free @entity8 in the urine, @entity5 starting in the 1st year of life, @entity6 and @entity4 . Several family members of both families were affected with the same disease indicating the hereditary @entity2 . The neuropathological investigation revealed strikingly similar changes in the two cases. Macroscopically the cerebral white matter was severely reduced. Histologically marked loss of axons and myelin sheaths was accompanied by pronounced astrocytic proliferation. The remaining axons frequently showed @entity1 surrounded by a myelin sheath. The reduction of the number of myelin sheaths seemed proportional to the numerical reduction of axons. Many cortical nerve cells displayed in relation to age an abnormal amount of @entity9 . @entity7 were observed in nerve cells of the neo-cortex, nucleus basalis of Meynert and locus ceruleus. Cerebellum showed moderate loss of Purkinje cells. In the spinal cord axonal degeneration was observed in both ascending and descending tracts.

title: Neuropathology of XXXX .

answer: @entity3


abstract: AIMS: To evaluate the effects of treating @entity3 grain with @entity1 (LA) and heat on postprandial dynamics of 19 microbial taxa and fermentation in the rumen of dairy @entity0 . METHODS AND RESULTS: This study was designed as a double 3 * 3 Latin square with 6 rumen-cannulated @entity0 and three diets either containing untreated control @entity3 or @entity3 treated with 1% LA and 1% @entity10 ( @entity10 , 55  C). Microbial populations, pH and volatile @entity2 were assessed in rumen liquid and solids during the postprandial period. @entity6 increased and @entity5 decreased in rumen solids of @entity0 fed LA and @entity10 treated @entity3 compared to the control @entity3 . The LA but not @entity10 treatment depressed @entity9 in rumen liquid and solids, whereas the opposite effect was observed for @entity8 in both fractions and @entity11 in rumen solids. LA promoted Ruminobacter amylophilus with the effect being more pronounced with @entity10 . The Lactobacillus group and @entity7 increased in both fractions with LA but not with @entity10 . CONCLUSIONS: LA and @entity10 treatment of @entity3 differently altered ruminal abundance of certain @entity4 and increased @entity6 fermentation in rumen solids, whereby LA and @entity10 effects were consistent and mostly independent of the rumen fraction and time after @entity3 feeding. SIGNIFICANCE AND IMPACT OF THE STUDY: Results provided evidence that LA and @entity10 treatment of @entity3 can enhance rumen @entity6 fermentation without adversely affecting rumen pH. As @entity6 is the major contributor to gluconeogenesis in ruminants, the present @entity3 treatment may have practical application to enhance energy supply in dairy @entity0 . This article is protected by copyright. All rights reserved.

title: Microbial populations and fermentation profiles in rumen liquid and solids of Holstein XXXX respond differently to dietary @entity3 processing.

answer: @entity0


abstract: AIMS: To evaluate the effects of treating @entity3 grain with @entity1 (LA) and heat on postprandial dynamics of 19 microbial taxa and fermentation in the rumen of dairy @entity0 . METHODS AND RESULTS: This study was designed as a double 3 * 3 Latin square with 6 rumen-cannulated @entity0 and three diets either containing untreated control @entity3 or @entity3 treated with 1% LA and 1% @entity10 ( @entity10 , 55  C). Microbial populations, pH and volatile @entity2 were assessed in rumen liquid and solids during the postprandial period. @entity6 increased and @entity5 decreased in rumen solids of @entity0 fed LA and @entity10 treated @entity3 compared to the control @entity3 . The LA but not @entity10 treatment depressed @entity9 in rumen liquid and solids, whereas the opposite effect was observed for @entity8 in both fractions and @entity11 in rumen solids. LA promoted Ruminobacter amylophilus with the effect being more pronounced with @entity10 . The Lactobacillus group and @entity7 increased in both fractions with LA but not with @entity10 . CONCLUSIONS: LA and @entity10 treatment of @entity3 differently altered ruminal abundance of certain @entity4 and increased @entity6 fermentation in rumen solids, whereby LA and @entity10 effects were consistent and mostly independent of the rumen fraction and time after @entity3 feeding. SIGNIFICANCE AND IMPACT OF THE STUDY: Results provided evidence that LA and @entity10 treatment of @entity3 can enhance rumen @entity6 fermentation without adversely affecting rumen pH. As @entity6 is the major contributor to gluconeogenesis in ruminants, the present @entity3 treatment may have practical application to enhance energy supply in dairy @entity0 . This article is protected by copyright. All rights reserved.

title: Microbial populations and fermentation profiles in rumen liquid and solids of Holstein @entity0 respond differently to dietary XXXX processing.

answer: @entity3


abstract: The introduction of oil-adjuvanted vaccines in salmon aquaculture made large-scale production feasible by reducing the impact of @entity1 . Vaccines given intraperitoneally (ip) contain oil adjuvant such as mineral oil. However, in rodents, a single ip injection of adjuvant @entity7 oil induces @entity5 . We have recently reported that @entity4 in farmed salmon, characterized by production of various autoantibodies, immune complex @entity2 , liver @entity3 , and @entity0 , are previously unrecognized side effects of vaccination. In the present study, we examined whether vaccination-induced autoantibody production in farmed @entity9 is a mere result of polyclonal B-cell activation. Sera were collected from 205 vaccinated and unvaccinated @entity9 (experimental, 7 farms) and wild salmon. Total IgM levels and autoantibodies to salmon blood cell (SBC) extract in sera were measured by ELISA and the relationship between @entity6 and autoantibody production was analyzed. Comparison of endpoint titers vs levels/units using a single dilution of sera in detection of autoantibodies to SBC showed near perfect correlation, justifying the use of the latter for screening. Both total IgM and anti-SBC antibodies are increased in vaccinated salmon compared with unvaccinated controls, however, they do not always correlate well when compared between groups or between individuals, suggesting the involvement of antigen-specific mechanisms in the production of anti-SBC autoantibodies. The primary considerations of successful vaccine for aquaculture are cost-effectiveness and safety. Vaccination-induced @entity4 in farmed @entity9 may have consequences on future vaccine development and salmon farming strategy. Evaluation for @entity8 and @entity4 should be included as an important trait when vaccine efficacy and safety are evaluated in future.

title: XXXX and autoantibody production induced by vaccination in farmed @entity9 .

answer: @entity6


abstract: The introduction of oil-adjuvanted vaccines in salmon aquaculture made large-scale production feasible by reducing the impact of @entity1 . Vaccines given intraperitoneally (ip) contain oil adjuvant such as mineral oil. However, in rodents, a single ip injection of adjuvant @entity7 oil induces @entity5 . We have recently reported that @entity4 in farmed salmon, characterized by production of various autoantibodies, immune complex @entity2 , liver @entity3 , and @entity0 , are previously unrecognized side effects of vaccination. In the present study, we examined whether vaccination-induced autoantibody production in farmed @entity9 is a mere result of polyclonal B-cell activation. Sera were collected from 205 vaccinated and unvaccinated @entity9 (experimental, 7 farms) and wild salmon. Total IgM levels and autoantibodies to salmon blood cell (SBC) extract in sera were measured by ELISA and the relationship between @entity6 and autoantibody production was analyzed. Comparison of endpoint titers vs levels/units using a single dilution of sera in detection of autoantibodies to SBC showed near perfect correlation, justifying the use of the latter for screening. Both total IgM and anti-SBC antibodies are increased in vaccinated salmon compared with unvaccinated controls, however, they do not always correlate well when compared between groups or between individuals, suggesting the involvement of antigen-specific mechanisms in the production of anti-SBC autoantibodies. The primary considerations of successful vaccine for aquaculture are cost-effectiveness and safety. Vaccination-induced @entity4 in farmed @entity9 may have consequences on future vaccine development and salmon farming strategy. Evaluation for @entity8 and @entity4 should be included as an important trait when vaccine efficacy and safety are evaluated in future.

title: @entity6 and autoantibody production induced by vaccination in farmed XXXX .

answer: @entity9


abstract: TBK1, also termed NAK or T2K, is a ubiquitous member of the IkB kinase (IKK) family that is required for innate and adaptive immune responses. We have identified and characterized the full-length TBK1 cDNA in @entity3 . The cod TBK1 gene consists of 2190 bp open reading frame encoding a polypeptide of 729 @entity1 . According to a BLAST search, the cloned TBK1 gene has a high degree of sequence similarity (80.7-92%) to the various members of the TBK1 family, indicating that it is conserved during evolution. RT-PCR showed that the largest quantity of TBK1 transcripts was found in spleen, followed by the liver, gill, head kidney, gut, pyloric caeca, while the expression of TBK1 mRNA in muscle and skin was low. Both @entity2 , @entity4 and b-glucan promoted expression of TBK1 transcripts in vivo. Furthermore, we determined an 875 bp sequence upstream of the @entity0 ( @entity0 ) and found a number of sequence motifs that matched known transcription factor-binding sites. Activities of the presumptive regulatory regions of this gene were assessed by transfecting different 5'-deletion constructs in CHSE-214 cells. After the expression experiments, the results showed that the basal promoters and positive transcriptional regulator activities of cod TBK1 gene were dependent by sequences located from -875 to -425 bp and from -245 to +28 bp upstream of @entity0 . This study provides further insights into the transcriptional regulation of cod TBK1.

title: Cloning, expression analysis and promoter structure of TBK1 (TANK-binding kinase 1) in XXXX ( @entity3 L.).

answer: @entity3


abstract: TBK1, also termed NAK or T2K, is a ubiquitous member of the IkB kinase (IKK) family that is required for innate and adaptive immune responses. We have identified and characterized the full-length TBK1 cDNA in @entity3 . The cod TBK1 gene consists of 2190 bp open reading frame encoding a polypeptide of 729 @entity1 . According to a BLAST search, the cloned TBK1 gene has a high degree of sequence similarity (80.7-92%) to the various members of the TBK1 family, indicating that it is conserved during evolution. RT-PCR showed that the largest quantity of TBK1 transcripts was found in spleen, followed by the liver, gill, head kidney, gut, pyloric caeca, while the expression of TBK1 mRNA in muscle and skin was low. Both @entity2 , @entity4 and b-glucan promoted expression of TBK1 transcripts in vivo. Furthermore, we determined an 875 bp sequence upstream of the @entity0 ( @entity0 ) and found a number of sequence motifs that matched known transcription factor-binding sites. Activities of the presumptive regulatory regions of this gene were assessed by transfecting different 5'-deletion constructs in CHSE-214 cells. After the expression experiments, the results showed that the basal promoters and positive transcriptional regulator activities of cod TBK1 gene were dependent by sequences located from -875 to -425 bp and from -245 to +28 bp upstream of @entity0 . This study provides further insights into the transcriptional regulation of cod TBK1.

title: Cloning, expression analysis and promoter structure of TBK1 (TANK-binding kinase 1) in @entity3 ( XXXX L.).

answer: @entity3


abstract: INTRODUCTION: The aim of this study was to evaluate the @entity3 burden of carotid atherosclerotic plaques removed from @entity0 treated for @entity2 and find any relation with @entity6 genotype and other common cardiovascular risk factors. METHODS: Consecutive @entity0 undergoing carotid endarterectomy were included in the study. All @entity0 had high-grade @entity4 (>70%). The clinical characteristics and serum parameters of the study population were recorded and the @entity6 genotype was determined. The presence of hemosiderin deposits in the plaques was identified using Perl's stain on adjacent serial sections. RESULTS: 70 specimens were processed for histologic examination: 27 plaques from @entity1 @entity0 (16 with the Hp 1-1 or 2-1 genotype and 11 with the Hp 2-2 genotype) and 43 plaques from non @entity1 @entity0 (20 with the Hp 1-1 or 2-1 genotype and 23 with the Hp 2-2 genotype). In plaques from @entity1 @entity0 the density of Perl's @entity3 stain was significantly higher in the Hp 2-2 group compared with that in the Hp 1-1 or 2-1 group (p = 0.008). The correlation and regression analysis of all possible clinical and laboratory predictors of intraplaque @entity3 deposition showed that four factors were independently associated with intraplaque @entity3 deposition: male gender, serum @entity5 , Hp 2-2 genotype and @entity1 treatment. CONCLUSIONS: Male @entity1 @entity0 with increased plasma levels of @entity5 and the Hp 2-2 genotype had higher carotid plaque @entity3 deposition. Current evidence and pathophysiological considerations suggest that the increased intraplaque @entity3 deposition may be associated with increased oxidative stress, affecting the stability of the carotid plaque.

title: Association of XXXX genotype and common cardiovascular risk factors with the amount of @entity3 in atherosclerotic carotid plaques.

answer: @entity6


abstract: INTRODUCTION: The aim of this study was to evaluate the @entity3 burden of carotid atherosclerotic plaques removed from @entity0 treated for @entity2 and find any relation with @entity6 genotype and other common cardiovascular risk factors. METHODS: Consecutive @entity0 undergoing carotid endarterectomy were included in the study. All @entity0 had high-grade @entity4 (>70%). The clinical characteristics and serum parameters of the study population were recorded and the @entity6 genotype was determined. The presence of hemosiderin deposits in the plaques was identified using Perl's stain on adjacent serial sections. RESULTS: 70 specimens were processed for histologic examination: 27 plaques from @entity1 @entity0 (16 with the Hp 1-1 or 2-1 genotype and 11 with the Hp 2-2 genotype) and 43 plaques from non @entity1 @entity0 (20 with the Hp 1-1 or 2-1 genotype and 23 with the Hp 2-2 genotype). In plaques from @entity1 @entity0 the density of Perl's @entity3 stain was significantly higher in the Hp 2-2 group compared with that in the Hp 1-1 or 2-1 group (p = 0.008). The correlation and regression analysis of all possible clinical and laboratory predictors of intraplaque @entity3 deposition showed that four factors were independently associated with intraplaque @entity3 deposition: male gender, serum @entity5 , Hp 2-2 genotype and @entity1 treatment. CONCLUSIONS: Male @entity1 @entity0 with increased plasma levels of @entity5 and the Hp 2-2 genotype had higher carotid plaque @entity3 deposition. Current evidence and pathophysiological considerations suggest that the increased intraplaque @entity3 deposition may be associated with increased oxidative stress, affecting the stability of the carotid plaque.

title: Association of @entity6 genotype and common cardiovascular risk factors with the amount of XXXX in atherosclerotic carotid plaques.

answer: @entity3


abstract: In the present study, we evaluated the diameter of internal acoustic canal in @entity0 with @entity5 to investigate the role of anatomical differences of the temporal bone in etiology of @entity5 . Sixty-four @entity0 who were diagnosed as @entity5 and temporal bone computed tomography imagings of them were included into the study group (Group 1). The control group (Group 2) was consisted of 35 healthy subjects without @entity5 . All @entity0 had temporal bone computed tomography imaging. The internal auditory canal inlet, mid-canal, outlet and canal lengths were measured at the most distinctive @entity2 . In the study group, @entity5 was on the right side in 26 @entity0 (40.6  %) and on the left side in 38 @entity0 (59.4  %). Initial House-Brackmann (HB) score was @entity3 in 29 @entity0 (45.3  %), @entity8 in 18 @entity0 (28.1  %), @entity6 in 13 @entity0 (20.3  %) and @entity7 in 4 @entity0 (6.2  %). At 6-month evaluation, HB-score of the @entity0 were @entity4 in 37 @entity0 (57.8  %), @entity3 in 25 @entity0 (39.1  %) and @entity8 in 2 @entity0 (3.1  %). Internal auditory canal (IAC) measurements of the groups showed that there were no significant differences between the measurements of right-mid canal, right canal length; and left canal outlet and left canal length of the study and control groups. Right inlet and outlet; and left inlet and mid-canal values of the study group ( @entity5 ) were significantly lower than those of the control group. In @entity5 group, left inlet, outlet and canal length values were significantly higher than those of the right ones. Correlation analysis showed that there were no significant correlation between @entity1 side; initial HB stage; and IAC measurement results. In @entity0 with higher initial HB score, their 6-month later HB-score was also higher. In @entity0 with higher 6-month HB score; R canal inlet, R mid-canal, L-canal inlet, and L-mid canal values were lower. Lower IAC inlet and mid-canal values were detected in @entity0 with @entity5 . Therefore narrow IAC inlet and mid-canal values may be one of the risk factors for @entity5 .

title: Is There a Relationship Between XXXX and Internal Auditory Canal?

answer: @entity5


abstract: Nodular regenerative @entity8 is a histopathological diagnosis characterized by the diffuse transformation of the liver parenchyma into regenerative nodules associated with rheumatologic and @entity9 , @entity4 immunosuppression or @entity7 . The authors report the case of a 60-year-old female @entity0 with a diagnosis of @entity2 submitted to liver transplantation complicated by a @entity5 . A second liver transplant was performed and after 6 months she developed @entity6 and peripheral @entity1 . The abdominal computed tomography (CT) showed an @entity13 . She underwent balloon angioplasty and an endovascular prosthesis was placed. The @entity0 remained asymptomatic under immunosuppression with tacrolymus for 4 years, when she complained of peripheral @entity1 and @entity6 . Laboratory work-up showed @entity3 and @entity11 with liver chemistry within the normal range. The @entity6 fluid analysis revealed a serum @entity6 albumin gradient superior to 1.1 g/L. Abdominal Doppler ultrasound and abdominopelvic CT angiogram confirmed endovascular prosthesis permeability. A percutaneous hepatic biopsy specimen was taken and histologic analysis showed, with reticulin stain, focal regenerative nodules of @entity12 hepatocytes and internodular hepatocyte atrophy, compatible with the diagnosis of @entity10 . The case described is of particular interest as the @entity10 occurred after liver transplantation complicated with @entity13 , which might have contributed in a crucial way to liver parenchyma transformation.

title: XXXX after Liver Transplantation Complicated with Inferior Vena Cava Stenosis: a Clue for Etiopathogenesis?

answer: @entity10


abstract: BACKGROUND: Psychotherapy is apparently an insufficient treatment for some @entity0 with mood or @entity2 . In this study the effectiveness of short-term and long-term psychotherapies was compared with that of psychoanalysis. METHODS: A total of 326 @entity1 outpatients with mood or @entity2 were randomly assigned to solution-focused therapy, short-term psychodynamic and long-term psychodynamic psychotherapies. Additionally, 41 @entity0 suitable for psychoanalysis were included in the study. The @entity0 were followed from the start of the treatment and assessed 9 times during a 5-year follow-up. The primary outcome measures on symptoms were the Beck Depression Inventory, the Hamilton Depression and Anxiety Rating Scales, and the Symptom Check List, @entity2 scale. Primary work ability and functional capacity measures were the Work Ability Index, the Work-subscale of the Social Adjustment Scale, and the Perceived Psychological Functioning Scale. RESULTS: A reduction in @entity1 symptoms and improvement in work ability and functional capacity was noted in all treatment groups during the 5-year follow-up. The short-term therapies were more effective than psychoanalysis during the first year, whereas the long-term therapy was more effective after 3years of follow-up. Psychoanalysis was most effective at the 5-year follow-up, which also marked the end of the psychoanalysis. CONCLUSIONS: Psychotherapy gives faster benefits than psychoanalysis, but in the long run psychoanalysis seems to be more effective. Results from trials, among @entity0 suitable for psychoanalysis and with longer follow-up, are needed before firm conclusions about the relative effectiveness of psychoanalysis and psychotherapy in the treatment of mood and @entity2 can be drawn.

title: Quasi-experimental study on the effectiveness of psychoanalysis, long-term and short-term psychotherapy on XXXX symptoms, work ability and functional capacity during a 5-year follow-up.

answer: @entity1


abstract: UNASSIGNED: We present the main results of the 2011-2012 survey of the Italian screening programmes for @entity1 carried out by the National centre for screening monitoring (Osservatorio nazionale screening, ONS) on behalf of the Ministry of Health. By the end of 2012, 112 programmes were active, of which 11 had been activated during 2012 and 4 during 2011. The national theoretical extension increased from 66% of Italians aged 50-69 years residing in areas covered by organized screening programmes in 2010 to 73.7% in 2012. The majority of programmes employ the fecal immunochemical test (FIT), while some have adopted flexible sigmoidoscopy (FS) once in a lifetime and FIT for non-responders to FS. Overall, about 7,744,000 subjects were invited to undergo FIT, 53.1% of those to be invited within the two years. The adjusted attendance rate was 47.1%and 3,531,937 subjects were screened. Large differences in the attendance rate were observed among regions. Positivity rate of FIT programmes was 5.2% at first screening (range: 1.0-12.4%) and 4.0% at repeat screening (range: 3.4-6.4%). The average attendance rate to total colonoscopy (TC) was 81.2% and in two regions (Molise and Campania) it was lower than 70%. Completion rate for total colonoscopy (TC) was 91%. Among the 1,316,327 subjects attending screening for the first time, the detection rate (DR) per 1,000 screened subjects was 2.0 for @entity0 and 9.1    for advanced @entity2 ( @entity4 , @entity2 with a diameter >= 1 cm, with villous/tubulo-villous type or high-grade @entity3 ). As expected, the corresponding figures in the 2,215,610 subjects at repeat screening were lower (1.0   and 6.8   for @entity0 and @entity4 , respectively). Many programmes reported some difficulties in guaranteeing TC in the appropriate time frame to FIT+ subjects: in 15% of cases the waiting time was longer than two months. Ten programmes in 2011 and eight in 2012 employed FS as the screening test: 24,549 subjects were screened in the two years, with an attendance rate of 24.5%. Overall, 85.9% of FSs were classified as complete. Overall, TC referral rate was 9.8% and the DR per 1,000 screened subjects was 3.0 and 48.2 for @entity0 and @entity4 , respectively.

title: Screening for XXXX in Italy: 2011-2012 survey.

answer: @entity1


abstract: OBJECTIVES: The aim of this study was to identify geographical differences in mortality from @entity3 in @entity0 living in the province of Zaragoza, Spain, as well as its possible association with socioeconomic factors. The utility of the MEDEA project's deprivation index in rural areas was also explored. METHODS: Census tracts were used in Zaragoza city as analysis units and municipalities were used for the rest of the province. Crude and smoothed standardized mortality ratios were calculated for each analysis unit through a Bayesian generalized mixed linear model. A deprivation index was obtained and was included in the model in quartiles. An exploratory analysis was also conducted, including a rural index in the province of Zaragoza. RESULTS: In Zaragoza city, mortality from @entity3 and other chronic @entity2 [code 571 of the 9th @entity1 ( @entity1 ) and K70, @entity4 .1, @entity6 , @entity7 , @entity5 .1.9 of the @entity1 -10] increased as the deprivation index increased. Mortality in the most deprived areas was twice that in the less deprived areas (relative risk [RR] 2.09, credible interval (CI): 1.53-2.83). In the rest of the province, geographical differences in mortality could not be explained by the deprivation index used. Nevertheless, municipalities with the highest values in the rural index showed a RR of 0.47 (CI: 0.18-0.92) compared with those with the lowest values. CONCLUSIONS: In Zaragoza city, mortality from @entity3 and other chronic @entity2 was higher in the most deprived census tracts than in the most affluent areas. This association was not found in the rest of the province, probably because of the low variability explained by the deprivation index. Municipalities with high rural values had the lowest risk of death from these diseases.

title: [ @entity0 inequalities and XXXX mortality (Zaragoza, Spain, 1996-2003)].

answer: @entity3


abstract: OBJECTIVES: The aim of this study was to identify geographical differences in mortality from @entity3 in @entity0 living in the province of Zaragoza, Spain, as well as its possible association with socioeconomic factors. The utility of the MEDEA project's deprivation index in rural areas was also explored. METHODS: Census tracts were used in Zaragoza city as analysis units and municipalities were used for the rest of the province. Crude and smoothed standardized mortality ratios were calculated for each analysis unit through a Bayesian generalized mixed linear model. A deprivation index was obtained and was included in the model in quartiles. An exploratory analysis was also conducted, including a rural index in the province of Zaragoza. RESULTS: In Zaragoza city, mortality from @entity3 and other chronic @entity2 [code 571 of the 9th @entity1 ( @entity1 ) and K70, @entity4 .1, @entity6 , @entity7 , @entity5 .1.9 of the @entity1 -10] increased as the deprivation index increased. Mortality in the most deprived areas was twice that in the less deprived areas (relative risk [RR] 2.09, credible interval (CI): 1.53-2.83). In the rest of the province, geographical differences in mortality could not be explained by the deprivation index used. Nevertheless, municipalities with the highest values in the rural index showed a RR of 0.47 (CI: 0.18-0.92) compared with those with the lowest values. CONCLUSIONS: In Zaragoza city, mortality from @entity3 and other chronic @entity2 was higher in the most deprived census tracts than in the most affluent areas. This association was not found in the rest of the province, probably because of the low variability explained by the deprivation index. Municipalities with high rural values had the lowest risk of death from these diseases.

title: [ XXXX inequalities and @entity3 mortality (Zaragoza, Spain, 1996-2003)].

answer: @entity0


abstract: PURPOSE: This study is to investigate the value of double contrast-enhanced ultrasonography (DCEU) in assessing microcirculation of @entity2 and to describe the perfusion features of the @entity1 . MATERIAL AND METHODS: DCEUS was performed in 42 @entity0 with @entity4 . The time-intensity curve parameters ( @entity5 ( @entity5 ), @entity5 ( @entity5 ), peak intensity (PI) and area under the curve (AUC)) within the @entity1 were extracted. The parameters were compared among the @entity1 with different CEUS features and stages. RESULTS: The mean values of @entity5 , @entity5 , PI and AUC of the @entity2 were 13.68  13.36s, 32.61  19.56s, 19.82  16.54dB and 271.10  159.19dBs, respectively. In the @entity4 with @entity3 , the mean values of AUC was significantly lower than that of the @entity4 without (231.10  219.27dBs, 278.10  123.20dBs, p=0.004). In the @entity4 with @entity3 , the AUC and PI of the non-necrotic part were significantly higher than that of the necrotic part (p=0.007, 0.0025, respectively). AUC increased progressively in the subgroups of T2, T3 and T4 and the difference of AUC between T2 and T4 subgroup was significant (p=0.008). CONCLUSIONS: Double contrast-enhanced ultrasonography is a valuable technique for quantifying @entity1 vascularity of @entity2 . AUC was significantly different in the subgroups of different T stage. AUC and PI could reflect the different perfusion status of @entity1 with or without @entity3 .

title: Features of time-intensity curve parameters of XXXX evaluated by double-contrast enhanced ultrasonography: initial observation.

answer: @entity2


abstract: The validity of self-report in @entity1 treatment research is controversial. Our recently completed Veterans Administration Cooperative Study evaluating the efficacy of @entity3 treatment for @entity1 provided an opportunity to assess the validity of self-report. To assess treatment response, @entity0 and household contacts were interviewed at seven scheduled points during the 1 year of follow-up. Blood specimens also were obtained from the @entity0 at these times and were analyzed for @entity2 . Eighty-eight percent of the @entity0 and/or collateral interviews were obtained at 6 months and 90% at 1 year. The mean number of blood and urine specimens collected per @entity0 was 4.3 and 14.4, respectively. Outcome criteria included continuous abstinence during the year and total number of drinking days. Continuous abstinence: If we had had only the @entity0 ' self reports, we would have significantly underestimated the percentage of @entity0 who drank. By self-report 58.7% (355/605) relapsed whereas the combination of self report, collaterals' reports, and laboratory tests indicated that 72.4% (438/605) drank (p less than 0.001). Using Bayes' theorem, the conditional probability that a @entity0 is continuously abstinent for 1 year when he so claims is 65%. Total drinking days: Of the 213 @entity0 -collateral pairs each of whom provided all seven scheduled interviews, 46.9% (100/213) agreed on the total number of drinking days during the year.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Validity of self-report in XXXX research: results of a Veterans Administration Cooperative Study.

answer: @entity1


abstract: BACKGROUND AND AIMS: Intestinal @entity3 is a frequently encountered side effect in oncology @entity0 undergoing chemotherapy. No well-established or up to date therapeutic strategies are available. To study a novel way to alleviate @entity3 , we investigate the effects and safety of probiotic supplementation in ameliorating @entity9 -induced @entity3 in a @entity2 model. METHODS: Seventy-two @entity2 were injected saline or @entity9 ( @entity9 ) intraperitoneally daily. @entity2 were either orally administrated daily saline, probiotic suspension of @entity10 casei variety rhamnosus (Lcr35) or @entity10 and @entity8 (LaBi). @entity4 score, pro-inflammatory cytokines serum levels, intestinal villus height and crypt depth and total RNA from tissue were assessed. Samples of blood, liver and spleen tissues were assessed for translocation. RESULTS: Marked diarrhea developed in the @entity9 groups but was attenuated after oral Lcr35 and LaBi administrations. @entity4 scores decreased significantly from 2.64 to 1.45 and 0.80, respectively (P<0.001). Those @entity2 in @entity9 groups had significantly higher proinflammatory cytokine levels ( @entity6 : 234.80 vs. 29.10, P<0.001, @entity7 : 25.13 vs. 7.43, P<0.001, IFN-y: 22.07 vs. 17.06, P = 0.137). A repairing of @entity1 was observed following probiotics administration. We also found @entity6 , @entity5 and @entity7 mRNA expressions were up-regulated in @entity3 tissues following @entity9 treatment ( @entity6 : 4.35 vs. 1.18, @entity5 : 2.29 vs. 1.07, @entity7 : 1.49 vs. 1.02) and that probiotics treatment suppressed this up-regulation (P<0.05). No bacterial translocation was found in this study. CONCLUSIONS: In conclusion, our results show that oral administration of probiotics Lcr35 and LaBi can ameliorate chemotherapy-induced @entity3 in a @entity2 model. This suggests probiotics may serve as an alternative therapeutic strategy for the prevention or management of chemotherapy-induced @entity3 in the future.

title: Amelioration of Chemotherapy-Induced Intestinal XXXX by Orally Administered Probiotics in a @entity2 Model.

answer: @entity3


abstract: BACKGROUND AND AIMS: Intestinal @entity3 is a frequently encountered side effect in oncology @entity0 undergoing chemotherapy. No well-established or up to date therapeutic strategies are available. To study a novel way to alleviate @entity3 , we investigate the effects and safety of probiotic supplementation in ameliorating @entity9 -induced @entity3 in a @entity2 model. METHODS: Seventy-two @entity2 were injected saline or @entity9 ( @entity9 ) intraperitoneally daily. @entity2 were either orally administrated daily saline, probiotic suspension of @entity10 casei variety rhamnosus (Lcr35) or @entity10 and @entity8 (LaBi). @entity4 score, pro-inflammatory cytokines serum levels, intestinal villus height and crypt depth and total RNA from tissue were assessed. Samples of blood, liver and spleen tissues were assessed for translocation. RESULTS: Marked diarrhea developed in the @entity9 groups but was attenuated after oral Lcr35 and LaBi administrations. @entity4 scores decreased significantly from 2.64 to 1.45 and 0.80, respectively (P<0.001). Those @entity2 in @entity9 groups had significantly higher proinflammatory cytokine levels ( @entity6 : 234.80 vs. 29.10, P<0.001, @entity7 : 25.13 vs. 7.43, P<0.001, IFN-y: 22.07 vs. 17.06, P = 0.137). A repairing of @entity1 was observed following probiotics administration. We also found @entity6 , @entity5 and @entity7 mRNA expressions were up-regulated in @entity3 tissues following @entity9 treatment ( @entity6 : 4.35 vs. 1.18, @entity5 : 2.29 vs. 1.07, @entity7 : 1.49 vs. 1.02) and that probiotics treatment suppressed this up-regulation (P<0.05). No bacterial translocation was found in this study. CONCLUSIONS: In conclusion, our results show that oral administration of probiotics Lcr35 and LaBi can ameliorate chemotherapy-induced @entity3 in a @entity2 model. This suggests probiotics may serve as an alternative therapeutic strategy for the prevention or management of chemotherapy-induced @entity3 in the future.

title: Amelioration of Chemotherapy-Induced Intestinal @entity3 by Orally Administered Probiotics in a XXXX Model.

answer: @entity2


abstract: UNASSIGNED: OBJECT The goal of this study was to examine the effectiveness of preoperative autologous blood donation (PABD) in @entity1 ( @entity1 ) surgery. METHODS @entity0 undergoing single-stay @entity1 reconstructions were identified in a multicenter database. @entity0 were divided into groups according to PABD (either PABD or NoPABD). Propensity weighting was used to create matched cohorts of PABD and NoPABD @entity0 . Allogeneic (ALLO) exposure, autologous (AUTO) wastage (unused AUTO), and complication rates were compared between groups. RESULTS Four hundred twenty-eight @entity0 were identified as meeting eligibility criteria. Sixty @entity0 were treated with PABD, of whom 50 were matched to 50 @entity0 who were not treated with PABD (NoPABD). Nearly one-third of @entity0 in the PABD group (18/60, 30%) did not receive any autologous transfusion and donated blood was wasted. In 6 of these cases (6/60, 10%), @entity0 received ALLO blood transfusions without AUTO. In 9 cases (9/60, 15%), @entity0 received ALLO and AUTO blood transfusions. Overall rates of transfusion of any type were similar between groups (PABD 70% [42/60], NoPABD 75% [275/368], p = 0.438). Major and minor in-hospital complications were similar between groups (Major PABD 10% [6/60], NoPABD 12% [43/368], p = 0.537; Minor PABD 30% [18/60], NoPABD 24% [87/368], p = 0.499). When controlling for potential confounders, PABD @entity0 were more likely to receive some transfusion (OR 15.1, 95% CI 2.1-106.7). No relationship between PABD and ALLO blood exposure was observed, however, refuting the concept that PABD is protective against ALLO blood exposure. In the matched cohorts, PABD @entity0 were more likely to sustain a major perioperative @entity3 (PABD 8/50 [16%], NoPABD 1/50 [2%], p = 0.046). No differences in rates of @entity4 were observed between cohorts. CONCLUSIONS Preoperative autologous blood donation was associated with a higher probability of perioperative transfusions of any type in @entity0 with @entity1 . No protective effect of PABD against ALLO blood exposure was observed, and no risk of perioperative @entity2 complications was observed in @entity0 exposed to ALLO blood only. The benefit of PABD in @entity0 with @entity1 remains undefined.

title: Effectiveness of preoperative autologous blood donation for protection against allogeneic blood exposure in XXXX surgeries: a propensity-matched cohort analysis.

answer: @entity1


abstract: UNASSIGNED: Mitochondria have been proposed as the major source of reactive @entity1 species in somatic cells and @entity0 spermatozoa. However, no data regarding the role of mitochondrial ROS production in stallion spermatozoa are available. To shed light on the role of the mitochondrial electron transport chain in the origin of oxidative stress in stallion spermatozoa, specific inhibitors of complex I ( @entity5 ) and III ( @entity7 -A) were used. Ejaculates from seven Andalusian stallions were collected and incubated in BWW media at 37  C in the presence of @entity5 , @entity6 or control vehicle. Incubation in the presence of these inhibitors reduced sperm motility and velocity ( @entity8 analysis) (p<0.01), but the effect was more evident in the presence of @entity5 (a complex I inhibitor). These inhibitors also decreased @entity4 content. The inhibition of complexes I and III decreased the production of reactive @entity1 species (p<0.01) as assessed by flow cytometry after staining with CellRox deep red. This observation suggests that the CellRox probe mainly identifies @entity2 and that @entity2 production may reflect intense mitochondrial activity rather than oxidative stress. The inhibition of complex I resulted in increased @entity3 production (p<0.01). The inhibition of glycolysis resulted in reduced sperm velocities (p<0.01) without an effect on the percentage of total motile sperm. Weak and moderate (but statistically significant) positive correlations were observed between sperm motility, velocity and membrane integrity and the production of reactive @entity1 species. These results indicate that stallion sperm rely heavily on oxidative phosphorylation (OXPHOS) for the production of @entity4 for motility but also require glycolysis to maintain high velocities. These data also indicate that increased @entity3 originating in the mitochondria is a mechanism involved in stallion sperm senescence.

title: Inhibition of Mitochondrial Complex I Leads to Decreased Motility and Membrane Integrity Related to Increased XXXX and Reduced @entity4 Production, while the Inhibition of Glycolysis Has Less Impact on Sperm Motility.

answer: @entity3


abstract: UNASSIGNED: Mitochondria have been proposed as the major source of reactive @entity1 species in somatic cells and @entity0 spermatozoa. However, no data regarding the role of mitochondrial ROS production in stallion spermatozoa are available. To shed light on the role of the mitochondrial electron transport chain in the origin of oxidative stress in stallion spermatozoa, specific inhibitors of complex I ( @entity5 ) and III ( @entity7 -A) were used. Ejaculates from seven Andalusian stallions were collected and incubated in BWW media at 37  C in the presence of @entity5 , @entity6 or control vehicle. Incubation in the presence of these inhibitors reduced sperm motility and velocity ( @entity8 analysis) (p<0.01), but the effect was more evident in the presence of @entity5 (a complex I inhibitor). These inhibitors also decreased @entity4 content. The inhibition of complexes I and III decreased the production of reactive @entity1 species (p<0.01) as assessed by flow cytometry after staining with CellRox deep red. This observation suggests that the CellRox probe mainly identifies @entity2 and that @entity2 production may reflect intense mitochondrial activity rather than oxidative stress. The inhibition of complex I resulted in increased @entity3 production (p<0.01). The inhibition of glycolysis resulted in reduced sperm velocities (p<0.01) without an effect on the percentage of total motile sperm. Weak and moderate (but statistically significant) positive correlations were observed between sperm motility, velocity and membrane integrity and the production of reactive @entity1 species. These results indicate that stallion sperm rely heavily on oxidative phosphorylation (OXPHOS) for the production of @entity4 for motility but also require glycolysis to maintain high velocities. These data also indicate that increased @entity3 originating in the mitochondria is a mechanism involved in stallion sperm senescence.

title: Inhibition of Mitochondrial Complex I Leads to Decreased Motility and Membrane Integrity Related to Increased @entity3 and Reduced XXXX Production, while the Inhibition of Glycolysis Has Less Impact on Sperm Motility.

answer: @entity4


abstract: Tissue factor (TF) is best known as a cellular initiator of coagulation, but it is also a multifunctional protein that has been implicated in multiple pathophysiologic conditions, including @entity2 . In the lung, airway epithelial cells express TF, but it is unknown how TF expression is regulated by @entity2 -associated mediators. We investigated the role of @entity3 , a type 2 cytokine, alone and in combination with compressive stress, which mimics asthmatic bronchoconstriction, on TF expression and release of TF-positive extracellular vesicles from primary normal @entity0 bronchial epithelial cells. Well-differentiated normal @entity0 bronchial epithelial cells were treated with @entity3 and compressive stress, alone and in combination. TF mRNA, protein and activity were measured in the cells and conditioned media. TF was also measured in the bronchoalveolar lavage (BAL) fluid of allergen-challenged @entity1 and @entity0 with @entity2 . @entity3 and compressive stress increased TF expression, but only compressive stress induced TF-positive extracellular vesicle release. Pretreatment with @entity3 augmented compressive stress-induced TF expression and release. TF protein and activity in BAL fluid were increased in allergen-sensitized and -challenged @entity1 . TF was elevated in the BAL fluid of @entity0 with mild @entity2 after an allergen challenge. Our in vitro and in vivo data indicate close cooperation between mechanical and inflammatory stimuli on TF expression and release of TF-positive extracellular vesicles in the lungs, which may contribute to pathophysiology of @entity2 .

title: XXXX Augments Compressive Stress-Induced Tissue Factor Expression in @entity0 Airway Epithelial Cells.

answer: @entity3


abstract: Tissue factor (TF) is best known as a cellular initiator of coagulation, but it is also a multifunctional protein that has been implicated in multiple pathophysiologic conditions, including @entity2 . In the lung, airway epithelial cells express TF, but it is unknown how TF expression is regulated by @entity2 -associated mediators. We investigated the role of @entity3 , a type 2 cytokine, alone and in combination with compressive stress, which mimics asthmatic bronchoconstriction, on TF expression and release of TF-positive extracellular vesicles from primary normal @entity0 bronchial epithelial cells. Well-differentiated normal @entity0 bronchial epithelial cells were treated with @entity3 and compressive stress, alone and in combination. TF mRNA, protein and activity were measured in the cells and conditioned media. TF was also measured in the bronchoalveolar lavage (BAL) fluid of allergen-challenged @entity1 and @entity0 with @entity2 . @entity3 and compressive stress increased TF expression, but only compressive stress induced TF-positive extracellular vesicle release. Pretreatment with @entity3 augmented compressive stress-induced TF expression and release. TF protein and activity in BAL fluid were increased in allergen-sensitized and -challenged @entity1 . TF was elevated in the BAL fluid of @entity0 with mild @entity2 after an allergen challenge. Our in vitro and in vivo data indicate close cooperation between mechanical and inflammatory stimuli on TF expression and release of TF-positive extracellular vesicles in the lungs, which may contribute to pathophysiology of @entity2 .

title: @entity3 Augments Compressive Stress-Induced Tissue Factor Expression in XXXX Airway Epithelial Cells.

answer: @entity0


abstract: BACKGROUND: Older case series established diagnostic considerations for @entity0 meeting a priori definitions of @entity2 of unknown origin (FUO). No recent study has examined the final diagnoses of @entity0 referred for unexplained @entity2 . METHODS: This study was conducted with a retrospective chart review of @entity0 referred to a pediatric @entity1 clinic from 2008 to 2012 for unexplained @entity2 . RESULTS: Sixty-nine of 221 @entity0 were referred for "prolonged" unexplained @entity2 . Ten of these were not actually having @entity2 , and 11 had diagnoses that were readily apparent at the initial visit. The remaining 48 were classified as having FUO. The median duration of reported @entity2 for these @entity0 was 30 days; 15 had a diagnosis made, 5 of which were serious. None of the serious FUO diagnoses were @entity3 . Of 152 @entity0 with "recurrent" unexplained @entity2 , 92 had an "intermittent" @entity2 pattern, and most of these had sequential, self-limited viral illnesses or no definitive diagnosis made. Twenty of the 60 @entity0 with a "periodic" @entity2 pattern were diagnosed with periodic @entity2 , @entity8 , @entity7 , and @entity6 . Overall, 166 @entity0 either were not having @entity2 , had self-limited illnesses, or ultimately had no cause of @entity2 discovered. Only 12 had a serious illness, 2 of which were @entity3 ( @entity4 and @entity5 ). CONCLUSIONS: Most @entity0 referred with unexplained @entity2 had either self-limited illnesses or no specific diagnosis established. Serious diagnoses were unusual, suggesting that these diagnoses rarely present with unexplained @entity2 alone, or that, when they do, the diagnoses are made by primary care providers or other subspecialists.

title: Characteristics of @entity0 Referred to a Pediatric XXXX Clinic With Unexplained Fever.

answer: @entity1


abstract: BACKGROUND: Older case series established diagnostic considerations for @entity0 meeting a priori definitions of @entity2 of unknown origin (FUO). No recent study has examined the final diagnoses of @entity0 referred for unexplained @entity2 . METHODS: This study was conducted with a retrospective chart review of @entity0 referred to a pediatric @entity1 clinic from 2008 to 2012 for unexplained @entity2 . RESULTS: Sixty-nine of 221 @entity0 were referred for "prolonged" unexplained @entity2 . Ten of these were not actually having @entity2 , and 11 had diagnoses that were readily apparent at the initial visit. The remaining 48 were classified as having FUO. The median duration of reported @entity2 for these @entity0 was 30 days; 15 had a diagnosis made, 5 of which were serious. None of the serious FUO diagnoses were @entity3 . Of 152 @entity0 with "recurrent" unexplained @entity2 , 92 had an "intermittent" @entity2 pattern, and most of these had sequential, self-limited viral illnesses or no definitive diagnosis made. Twenty of the 60 @entity0 with a "periodic" @entity2 pattern were diagnosed with periodic @entity2 , @entity8 , @entity7 , and @entity6 . Overall, 166 @entity0 either were not having @entity2 , had self-limited illnesses, or ultimately had no cause of @entity2 discovered. Only 12 had a serious illness, 2 of which were @entity3 ( @entity4 and @entity5 ). CONCLUSIONS: Most @entity0 referred with unexplained @entity2 had either self-limited illnesses or no specific diagnosis established. Serious diagnoses were unusual, suggesting that these diagnoses rarely present with unexplained @entity2 alone, or that, when they do, the diagnoses are made by primary care providers or other subspecialists.

title: Characteristics of XXXX Referred to a Pediatric @entity1 Clinic With Unexplained Fever.

answer: @entity0


abstract: BACKGROUND: Few data relate interferon-y-release-assay results in @entity0 to source case sputum status, the best predictor of infectiousness of @entity2 ( @entity2 ) @entity0 . We evaluated the QuantiFERON-Gold-in-tube assay (QFT) and @entity1 ( @entity1 ) in @entity0 with different types of @entity2 exposure. METHODS: The @entity1 and QFT were performed in referred @entity2 -exposed @entity0 and adolescents who had not undergone prior @entity1 screening (tested in parallel), and the QFT was performed in referred @entity1 -positive individuals. Source case characteristics were obtained from referring public health units. We excluded @entity0 with known immunocompromising conditions and those known to have @entity2 disease at the time of evaluation. RESULTS: For 103 @entity0 tested in parallel, overall test agreement was very good in the Bacillus Calmette-Guerein (BCG) unimmunized contacts (k = 0.83) and contacts of household smear-positive (HS+) cases (k = 0.67), but test agreement was poor in those with lower-risk contact (k = 0.34). Only 3 of 59 HS+ @entity0 were QFT-positive and @entity1 -negative. On multivariate analysis, a positive QFT was strongly associated with HS+ exposure (odds ratio [OR], 6.6; 95% confidence interval [CI], 2.2-20]) but not BCG; and a positive @entity1 was associated with BCG alone. For 92 referred @entity1 -positive individuals, the QFT was negative in 21% of HS+ contacts, 65% of lower-risk contacts (OR, 6.8; 95% CI, 1.9-25), and 82% of the @entity0 with unknown contact history (OR, 15.5; 95% CI, 5-54). Application of the Canadian 2010 guidelines would exclude from treatment 43 (72%) of the 73 @entity1 +, QFT- @entity0 . CONCLUSIONS: For close contacts of HS+ individuals, the QFT added little sensitivity to the @entity1 for detection of @entity2 . The QFT correlated much better with exposure than the @entity1 , especially in BCG-immunized @entity0 , and it has the greatest potential benefit for evaluation of those at lower risk of @entity3 .

title: Relating XXXX Characteristics to QuantiFERON- @entity2 -Gold and Tuberculin Skin Test Results in the Toronto Pediatric @entity2 Clinic.

answer: @entity2


abstract: BACKGROUND: Few data relate interferon-y-release-assay results in @entity0 to source case sputum status, the best predictor of infectiousness of @entity2 ( @entity2 ) @entity0 . We evaluated the QuantiFERON-Gold-in-tube assay (QFT) and @entity1 ( @entity1 ) in @entity0 with different types of @entity2 exposure. METHODS: The @entity1 and QFT were performed in referred @entity2 -exposed @entity0 and adolescents who had not undergone prior @entity1 screening (tested in parallel), and the QFT was performed in referred @entity1 -positive individuals. Source case characteristics were obtained from referring public health units. We excluded @entity0 with known immunocompromising conditions and those known to have @entity2 disease at the time of evaluation. RESULTS: For 103 @entity0 tested in parallel, overall test agreement was very good in the Bacillus Calmette-Guerein (BCG) unimmunized contacts (k = 0.83) and contacts of household smear-positive (HS+) cases (k = 0.67), but test agreement was poor in those with lower-risk contact (k = 0.34). Only 3 of 59 HS+ @entity0 were QFT-positive and @entity1 -negative. On multivariate analysis, a positive QFT was strongly associated with HS+ exposure (odds ratio [OR], 6.6; 95% confidence interval [CI], 2.2-20]) but not BCG; and a positive @entity1 was associated with BCG alone. For 92 referred @entity1 -positive individuals, the QFT was negative in 21% of HS+ contacts, 65% of lower-risk contacts (OR, 6.8; 95% CI, 1.9-25), and 82% of the @entity0 with unknown contact history (OR, 15.5; 95% CI, 5-54). Application of the Canadian 2010 guidelines would exclude from treatment 43 (72%) of the 73 @entity1 +, QFT- @entity0 . CONCLUSIONS: For close contacts of HS+ individuals, the QFT added little sensitivity to the @entity1 for detection of @entity2 . The QFT correlated much better with exposure than the @entity1 , especially in BCG-immunized @entity0 , and it has the greatest potential benefit for evaluation of those at lower risk of @entity3 .

title: Relating @entity2 Characteristics to QuantiFERON- XXXX -Gold and Tuberculin Skin Test Results in the Toronto Pediatric @entity2 Clinic.

answer: @entity2


abstract: BACKGROUND: Few data relate interferon-y-release-assay results in @entity0 to source case sputum status, the best predictor of infectiousness of @entity2 ( @entity2 ) @entity0 . We evaluated the QuantiFERON-Gold-in-tube assay (QFT) and @entity1 ( @entity1 ) in @entity0 with different types of @entity2 exposure. METHODS: The @entity1 and QFT were performed in referred @entity2 -exposed @entity0 and adolescents who had not undergone prior @entity1 screening (tested in parallel), and the QFT was performed in referred @entity1 -positive individuals. Source case characteristics were obtained from referring public health units. We excluded @entity0 with known immunocompromising conditions and those known to have @entity2 disease at the time of evaluation. RESULTS: For 103 @entity0 tested in parallel, overall test agreement was very good in the Bacillus Calmette-Guerein (BCG) unimmunized contacts (k = 0.83) and contacts of household smear-positive (HS+) cases (k = 0.67), but test agreement was poor in those with lower-risk contact (k = 0.34). Only 3 of 59 HS+ @entity0 were QFT-positive and @entity1 -negative. On multivariate analysis, a positive QFT was strongly associated with HS+ exposure (odds ratio [OR], 6.6; 95% confidence interval [CI], 2.2-20]) but not BCG; and a positive @entity1 was associated with BCG alone. For 92 referred @entity1 -positive individuals, the QFT was negative in 21% of HS+ contacts, 65% of lower-risk contacts (OR, 6.8; 95% CI, 1.9-25), and 82% of the @entity0 with unknown contact history (OR, 15.5; 95% CI, 5-54). Application of the Canadian 2010 guidelines would exclude from treatment 43 (72%) of the 73 @entity1 +, QFT- @entity0 . CONCLUSIONS: For close contacts of HS+ individuals, the QFT added little sensitivity to the @entity1 for detection of @entity2 . The QFT correlated much better with exposure than the @entity1 , especially in BCG-immunized @entity0 , and it has the greatest potential benefit for evaluation of those at lower risk of @entity3 .

title: Relating @entity2 Characteristics to QuantiFERON- @entity2 -Gold and Tuberculin Skin Test Results in the Toronto Pediatric XXXX Clinic.

answer: @entity2


abstract: We describe the case of a healthy, pregnant female who developed @entity6 at the time of delivery, and discuss the possible mechanism of @entity2 and the management of this case. A 26-year-old Asian @entity0 presented with a 3-week history of @entity1 and @entity8 . There was no history of @entity5 or surgery. The ocular symptoms developed one day after vaginal delivery of a healthy baby. The pregnancy had been uncomplicated until premature rupture of membranes one week prior to delivery. Right visual acuity was light perception. There was marked right anterior chamber activity with a hypopyon and fibrin. A B-scan ultrasound showed dense vitritis. Examination of the left eye was normal. Blood tests and a chest X-ray were normal. A vitreous tap was performed and bacterial culture grew Sphingomonas paucimobilis. Intravitreal antibiotics were injected ( @entity9 0.4 mg/0.1 ml and @entity4 2.0 mg/0.1 ml) and the @entity0 was treated with oral @entity7 and @entity3 . Right visual acuity improved to 6/9. This case highlights the need for clinicians to have a high level of awareness of endogenous @entity6 (a rare, potentially sight-threatening condition) in any @entity0 with a painful @entity1 in the peripartum period, particularly if associated with complications such as @entity10 .

title: A rare case of peripartum endogenous XXXX .

answer: @entity6


abstract: Transition from acute @entity2 to either recovery or chronicity and the development of chronic @entity1 ( @entity1 ) remains a challenging issue for researchers and clinicians. The roles of social support and personality traits in long-term functioning following whiplash have not been studied concomitantly. The present study aimed to examine whether social support and personality traits are related to long-term functioning following whiplash. One hundred forty-three subjects, who had experienced a @entity2 in a traffic accident 10-26  months before the study took place, participated. The initial diagnoses were a 'sprain of the neck' (ICD-9 code 847.0); only the outcome of grades I-III acute @entity1 was studied. Long-term functioning was considered within the biopsychosocial model: it was expressed in terms of disability, functional status, quality of life and psychological well-being. @entity0 filled out a set of questionnaires to measure the long-term functioning parameters (i.e. the Neck Disability Index, Medical Outcome Study Short-Form General Health Survey, Anamnestic Comparative Self-Assessment measure of overall well-being and the Symptom Checklist-90) and potential determinants of long-term functioning (the Dutch Personality Questionnaire and the Social Support List). The results suggest that social support (especially the discrepancies dimension of social support) and personality traits (i.e. inadequacy, self-satisfaction and resentment) are related to long-term functioning following @entity2 (Spearman rho varied between 0.32 and 0.57; p   <   0.01). Within the discrepancy dimension, everyday emotional support, emotional support during problems, appreciative support and informative support were identified as important correlates of long-term functioning. Future prospective studies are required to confirm the role of social support and personality traits in relation to long-term functioning following whiplash. For such studies, a broad view of long-term functioning within the biopsychological model should be applied.

title: Long-term functioning following XXXX : the role of social support and personality traits.

answer: @entity2


abstract: BACKGROUND: Regular colonoscopic surveillance for detection of @entity6 is recommended in longstanding @entity2 ( @entity2 ), however, its sensitivity is disputed. Screening accuracy may increase by using a biomarker-based surveillance strategy. METHODS: A case-control study was performed to determine the prognostic value of DNA ploidy and @entity5 in @entity2 -related @entity0 . Cases with @entity2 -related @entity1 ( @entity1 ), detected in our surveillance program between 1985-2008, were selected and matched with two controls, for age, gender, disease characteristics, interval of follow-up, PSC, and previous surgery. Biopsies were assessed for DNA ploidy, @entity5 , grade of @entity3 and @entity0 . Progression to @entity0 was analyzed with Cox regression analysis, adjusting for potentially confounding variables. RESULTS: Adjusting for age, we found statistically significant Hazard ratios (HR) between development of @entity1 , and @entity4 (HR5.5; 95%CI 2.6-11.5), abnormal DNA ploidy ( @entity7 .06-1.34, HR4.7; 95%CI 2.9-7.8 and DI>1.34, HR6.6; 95%CI 3.7-11.7) and @entity5 immunopositivity (HR3.0; 95%CI 1.9-4.7) over time. When adjusting for all confounders, abnormal DNA ploidy ( @entity7 .06-1.34, HR4.7; 95%CI 2.7-7.9 and DI>1.34, HR5.0; 95%CI 2.5-10.0) and @entity5 immunopositivity (HR1.7; 95%CI 1.0-3.1) remained statistically significant predictive of @entity0 . CONCLUSION: In longstanding @entity2 , abnormal DNA ploidy and @entity5 immunopositivity are important risk factors of developing @entity1 . The yield of surveillance may potentially increase by adding these biomarkers to the routine assessment of biopsies.

title: Biomarker-based prediction of @entity2 -related XXXX : a case-control study.

answer: @entity1


abstract: BACKGROUND: Regular colonoscopic surveillance for detection of @entity6 is recommended in longstanding @entity2 ( @entity2 ), however, its sensitivity is disputed. Screening accuracy may increase by using a biomarker-based surveillance strategy. METHODS: A case-control study was performed to determine the prognostic value of DNA ploidy and @entity5 in @entity2 -related @entity0 . Cases with @entity2 -related @entity1 ( @entity1 ), detected in our surveillance program between 1985-2008, were selected and matched with two controls, for age, gender, disease characteristics, interval of follow-up, PSC, and previous surgery. Biopsies were assessed for DNA ploidy, @entity5 , grade of @entity3 and @entity0 . Progression to @entity0 was analyzed with Cox regression analysis, adjusting for potentially confounding variables. RESULTS: Adjusting for age, we found statistically significant Hazard ratios (HR) between development of @entity1 , and @entity4 (HR5.5; 95%CI 2.6-11.5), abnormal DNA ploidy ( @entity7 .06-1.34, HR4.7; 95%CI 2.9-7.8 and DI>1.34, HR6.6; 95%CI 3.7-11.7) and @entity5 immunopositivity (HR3.0; 95%CI 1.9-4.7) over time. When adjusting for all confounders, abnormal DNA ploidy ( @entity7 .06-1.34, HR4.7; 95%CI 2.7-7.9 and DI>1.34, HR5.0; 95%CI 2.5-10.0) and @entity5 immunopositivity (HR1.7; 95%CI 1.0-3.1) remained statistically significant predictive of @entity0 . CONCLUSION: In longstanding @entity2 , abnormal DNA ploidy and @entity5 immunopositivity are important risk factors of developing @entity1 . The yield of surveillance may potentially increase by adding these biomarkers to the routine assessment of biopsies.

title: Biomarker-based prediction of XXXX -related @entity1 : a case-control study.

answer: @entity2


abstract: Diffuse @entity4 (WHO grade II) typically present as slow-growing @entity1 showing significant cellular differentiation, but possessing a tendency towards malignant progression. They account for ~10% of all @entity1 , with a peak incidence between 30 and 40 years of age. Median survival is reported as around 6-8 years. Mutations of @entity6 and @entity5 have been described as @entity2 , while copy number alterations are also relatively common. However, there is some evidence to suggest that these characteristics may vary with age. Here, we present an integrated clinicopathologic, genomic and transcriptomic analysis suggesting that @entity1 are associated with distinct genetic signatures. For example, no childhood @entity1 showed mutation of @entity10 or @entity6 , virtually no copy number changes were seen, and @entity9 methylation was absent. In contrast, @entity1 showed @entity10 mutation in 94% and @entity6 mutation in 69% of cases, with multiple copy number alterations per case and hypermethylation of @entity9 in the majority of @entity1 . These differences were associated with a worse prognosis in the adult @entity0 . The expression array data also revealed a significant difference in the expression of a number of genes putatively involved in neural stem cell maintenance and CNS development, including @entity13 , @entity12 , @entity7 , @entity8 and @entity11 . Genes involved in DNA replication and the cell cycle were also enriched in the @entity1 , suggesting that their more @entity3 may be due to derivation from a more rapidly dividing, less differentiated cell type.

title: Adult grade II diffuse XXXX are genetically distinct from and more @entity3 than their paediatric counterparts.

answer: @entity4


abstract: Diffuse @entity4 (WHO grade II) typically present as slow-growing @entity1 showing significant cellular differentiation, but possessing a tendency towards malignant progression. They account for ~10% of all @entity1 , with a peak incidence between 30 and 40 years of age. Median survival is reported as around 6-8 years. Mutations of @entity6 and @entity5 have been described as @entity2 , while copy number alterations are also relatively common. However, there is some evidence to suggest that these characteristics may vary with age. Here, we present an integrated clinicopathologic, genomic and transcriptomic analysis suggesting that @entity1 are associated with distinct genetic signatures. For example, no childhood @entity1 showed mutation of @entity10 or @entity6 , virtually no copy number changes were seen, and @entity9 methylation was absent. In contrast, @entity1 showed @entity10 mutation in 94% and @entity6 mutation in 69% of cases, with multiple copy number alterations per case and hypermethylation of @entity9 in the majority of @entity1 . These differences were associated with a worse prognosis in the adult @entity0 . The expression array data also revealed a significant difference in the expression of a number of genes putatively involved in neural stem cell maintenance and CNS development, including @entity13 , @entity12 , @entity7 , @entity8 and @entity11 . Genes involved in DNA replication and the cell cycle were also enriched in the @entity1 , suggesting that their more @entity3 may be due to derivation from a more rapidly dividing, less differentiated cell type.

title: Adult grade II diffuse @entity4 are genetically distinct from and more XXXX than their paediatric counterparts.

answer: @entity3


abstract: PURPOSE: @entity5 is a rare cause of @entity3 in the neonate. A review of the management and outcome of @entity0 with @entity5 was performed. METHODS: A retrospective analysis of the complete records of @entity0 treated for @entity5 during the 30-year period. RESULTS: A total of 14 newborns were treated. Seven @entity0 suffered from an isolated @entity5 (group 1). In the other seven @entity0 (group 2), @entity5 was either associated with additional intestinal @entity2 (n = 2), or @entity4 (n = 5). Gestational age and birth weight were significantly lower in @entity0 from group 2 compared to group 1 (40    0.5 vs. 37    1 weeks (P < 0.05); and 3,478    208 vs. 2,626    242 g (P < 0.01), respectively). The first surgical procedure was performed in all newborns within 24 h after birth. All but one @entity0 from group 1 received primary colostomies at the level of @entity5 , followed by end-to-side anastomoses. All but one @entity0 from group 2 needed ileocoecal resection due to bowel @entity1 . No @entity0 died in group 1, whereas three @entity0 died in group 2. CONCLUSIONS: Isolated @entity5 is amenable with a short hospital stay and an excellent outcome. In contrast, @entity0 with @entity5 associated with @entity4 present a serious clinical challenge.

title: Management of isolated and associated XXXX .

answer: @entity5


abstract: BACKGROUND: @entity3 are frequent after surgery for @entity1 . @entity4 ( @entity4 ) improves local recurrence and survival rates, and does not hamper recognition and sparing of @entity6 . It is not known how laparoscopic rectal resection could change functional complication rates. MATERIALS AND METHODS: From a global series of 1,216 laparoscopic interventions for @entity2 , 35 cases of males less than 70  years old, undergoing rectal resection and @entity4 for a T1-3M0 medium and low @entity1 were selected. Urinary and sexual functions after the operations were retrospectively recorded by means of specific tools (International Prostate Symptom Score (IPSS) and IIEF questionnaires, respectively). RESULTS: None of the @entity0 necessitated permanent or intermittent catheterization. More than half the @entity0 had no complaints about urinary functions; about one third had @entity8 ; 72% of the @entity0 had an IPSS less that 10, and no case of IPSS worse that 31 was recorded. Sexual desire was reduced and spontaneous erectile function was impaired in almost half the cases, while induced erections were possible in about 90% of cases; about 70% of @entity0 still had the possibility of penetration and a normal ejaculation and orgasm after the intervention. DISCUSSION AND CONCLUSIONS: The present series confirms previous data and contribute to the creation of a benchmark specifically related to the laparoscopic approach to which surgeons should face when informing the @entity0 before the operation. While severe @entity7 is rare, @entity5 remains a serious concern after rectal resection with @entity4 .

title: @entity3 after laparoscopic XXXX for @entity1 in males.

answer: @entity4


abstract: BACKGROUND: @entity3 are frequent after surgery for @entity1 . @entity4 ( @entity4 ) improves local recurrence and survival rates, and does not hamper recognition and sparing of @entity6 . It is not known how laparoscopic rectal resection could change functional complication rates. MATERIALS AND METHODS: From a global series of 1,216 laparoscopic interventions for @entity2 , 35 cases of males less than 70  years old, undergoing rectal resection and @entity4 for a T1-3M0 medium and low @entity1 were selected. Urinary and sexual functions after the operations were retrospectively recorded by means of specific tools (International Prostate Symptom Score (IPSS) and IIEF questionnaires, respectively). RESULTS: None of the @entity0 necessitated permanent or intermittent catheterization. More than half the @entity0 had no complaints about urinary functions; about one third had @entity8 ; 72% of the @entity0 had an IPSS less that 10, and no case of IPSS worse that 31 was recorded. Sexual desire was reduced and spontaneous erectile function was impaired in almost half the cases, while induced erections were possible in about 90% of cases; about 70% of @entity0 still had the possibility of penetration and a normal ejaculation and orgasm after the intervention. DISCUSSION AND CONCLUSIONS: The present series confirms previous data and contribute to the creation of a benchmark specifically related to the laparoscopic approach to which surgeons should face when informing the @entity0 before the operation. While severe @entity7 is rare, @entity5 remains a serious concern after rectal resection with @entity4 .

title: XXXX after laparoscopic @entity4 for @entity1 in males.

answer: @entity3