abstract: OBJECTIVE: To give an overview on intraoperative magnetic resonance (MR) imaging in @entity2 surgery. MATERIAL AND METHODS: MR imaging was performed using a 0.2T scanner, located in a radiofrequency-shielded operating theatre. Two setups were used: surgery either in a neighbouring operating theatre, or directly at the 5G line. Additionally, in @entity2 adjacent to eloquent brain areas microscope- or pointer-based neuronavigation with integrated functional data was applied. 106 @entity2 were among the 330 @entity0 investigated in the last 5 years. RESULTS: We did not observe complications attributable to intraoperative MR imaging. Image quality was sufficient to evaluate the extent of the @entity1 resection in the majority of cases. Intraoperative imaging revealed remaining @entity1 in 63%. In a total of 26% @entity0 @entity1 could be removed due to the results of intraoperative imaging, increasing the rate of @entity1 removal especially in the low-grade @entity1 . The additional use of functional neuronavigation prevented an increased morbidity. CONCLUSION: Intraoperative MR imaging offers the possibility of @entity1 removal during the same surgical procedure in case of @entity1 remnants, increasing the rate of @entity1 removal. The effects of brain shift can be compensated for using intraoperative image data for updating.

title: XXXX surgery evaluated by intraoperative low-field magnetic resonance imaging.

answer: @entity2


abstract: BACKGROUND: Development of an image-guided operation theatre offering multimodal information for mini-invasive @entity3 operations. METHODS: A multi-purpose resistive low-field MR scanner with on-off capability, was installed in a radio frequency-shielded operating room with in-room control panel and display. Intraoperative ultrasound imaging with Doppler mode as needed is used to provide check-up image data between intraoperative MR-imaging sessions. Cortical stimulation and registration are performed during awake craniotomies. The neuronavigation systems are customised arm-based and passive optical. The navigation systems show the positions of the ultrasound probe, cortical stimulation electrode, biopsy needles, endoscope and other instruments on the intraoperative MR-images. FINDINGS: Since 1999, 70 @entity0 (mean age 47, range 3-88 years) have been operated with intraoperative MR-guidance (including 10 @entity1 biopsies, 56 resections). Twenty-one @entity0 (mean age 46, range 16-67 years) underwent awake craniotomy and @entity1 resection secured with cortical stimulation and usually preoperative fMR-imaging. The present operating environment offered useful multimodal information for surgery of @entity3 in critical locations. Surgical mortality was 0%, morbidity included 3 (4.3%) infections and 2 (2.9%) permanent @entity2 . Further @entity1 was continued in 17 cases (57%) out of the 30 cases where intraoperative MR imaging was used for controlling completeness of the resection.

title: Intraoperative imaging in a comprehensive neuronavigation environment for minimally invasive XXXX surgery.

answer: @entity3


abstract: BACKGROUND: Severe hemophilia requires life-long treatment with expensive clotting factor concentrates; studies comparing effects of different therapeutic strategies over decades are very difficult to perform. A simulation model was developed to evaluate the long-term outcome of on demand, prophylactic and mixed treatment strategies for @entity0 with severe @entity1 . DESIGN AND METHODS: A computer model was developed based on individual @entity0 ' data from a Dutch cohort study in which intermediate dose prophylaxis was used and a French cohort study in which on demand treatment was used, and multivariate regression analyses. This model simulated individual @entity0 ' life expectancy, onset of @entity2 , life-time joint @entity2 , radiological outcome and concentrate use according to the different treatment strategies. RESULTS: According to the model, life-time on demand treatment would result in an average of 1,494 joint @entity2 during the hemophiliac's life, and consumption of 4.9 million IU of factor VIII concentrate. In contrast, life-time intermediate dose prophylaxis resulted in a mean of 357 joint @entity2 and factor consumption of 8.3 million IU. A multiple switch strategy (between prophylactic and on demand treatment based on @entity2 pattern) resulted in a mean number of 395 joint @entity2 and factor consumption of 6.6 million IU. The estimated proportion of @entity0 with Pettersson scores over 28 points was 32% for both the prophylactic and the multiple switching strategies, compared to 76% for continuous on demand treatment. CONCLUSIONS: The present model allows evaluation of the impact of various treatment strategies on @entity0 ' joint @entity2 and clotting factor consumption. It may be expanded with additional data to allow more precise estimates and include economic evaluations of treatment strategies.

title: A modeling approach to evaluate long-term outcome of prophylactic and on demand treatment strategies for severe XXXX .

answer: @entity1


abstract: BACKGROUND: @entity3 is a common complication of @entity1 ( @entity1 ). Circulating cell-derived microparticles (MPs) have emerged as reliable biomarkers of @entity3 and @entity5 . METHODS: @entity0 underwent blood drawing the morning after a sleep study. Endothelial function was assessed using a modified hyperemic test after cuff-induced occlusion of the brachial artery. Circulating MP levels in plasma, including levels of endothelial MPs, endothelial progenitor MPs, leukocyte MPs, and platelet MPs, were measured using flow cytometry after staining with cell-specific antibodies. RESULTS: The levels of endothelial MPs, endothelial progenitor MPs, leukocyte MPs, and platelet MPs were significantly different according to the severity of @entity1 in @entity0 . Leukocyte @entity9 + MPs and platelet CD41a+ MPs correlated with the @entity1 index (AHI) (r = 0.334, P < .001; and r = 0.301, P < .001, respectively), and associations emerged between leukocyte @entity9 + MPs and @entity6 (r = 0.206, P < .05) and between endothelial MPs and low-density lipoprotein @entity2 (r = 0.240, P < .01). In a multivariate regression model, the BMI z score (b    SE, 0.045    0.020; P = .020) and the @entity8 a MPs to leukocyte @entity7 MPs ratio (b    SE, 0.074    0.032; P = .021) were independently associated with peak hyperemic responses. After controlling for age, gender, race, BMI z score, and @entity6 levels, endothelial MPs, endothelial progenitor MPs, and leukocyte MPs showed independent associations with the AHI. Complex significant associations emerged between endothelial function, the AHI, and @entity8 a MPs. CONCLUSIONS: Childhood @entity1 is associated with higher circulating MP levels that can promote cardiovascular risk. Platelet-derived MPs emerge as being significantly associated with the @entity4 associated with @entity1 in @entity0 and could potentially account for increased risk for altered endothelial function. However, the clinical use of MPs as reliable biomarker indicators of vascular risk will have to await further studies.

title: Circulating microparticles in XXXX with sleep disordered breathing.

answer: @entity0


abstract: BACKGROUND: Quantifying @entity3 ( @entity3 ) prevalence and incidence is important for planning interventions and advocating for resources. The World Health Organization (WHO) periodically estimates global and regional prevalence and incidence of four curable STIs: @entity2 , gonorrhoea, trichomoniasis and syphilis. METHODS AND FINDINGS: WHO's 2012 estimates were based upon literature reviews of prevalence data from 2005 through 2012 among general populations for @entity1 with @entity2 , gonorrhoea, and trichomoniasis, and nationally reported data on syphilis seroprevalence among antenatal care attendees. Data were standardized for laboratory test type, geography, age, and high risk subpopulations, and combined using a Bayesian meta-analytic approach. Regional incidence estimates were generated from prevalence estimates by adjusting for average duration of @entity1 . In 2012, among @entity0 aged 15-49 years, the estimated global prevalence of @entity2 was 4.2% (95% uncertainty interval (UI): 3.7-4.7%), gonorrhoea 0.8% (0.6-1.0%), trichomoniasis 5.0% (4.0-6.4%), and syphilis 0.5% (0.4-0.6%); among @entity0 , estimated @entity2 prevalence was 2.7% (2.0-3.6%), gonorrhoea 0.6% (0.4-0.9%), trichomoniasis 0.6% (0.4-0.8%), and syphilis 0.48% (0.3-0.7%). These figures correspond to an estimated 131 million new cases of @entity2 (100-166 million), 78 million of gonorrhoea (53-110 million), 143 million of trichomoniasis (98-202 million), and 6 million of syphilis (4-8 million). Prevalence and incidence estimates varied by region and sex. CONCLUSIONS: Estimates of the global prevalence and incidence of @entity2 , gonorrhoea, trichomoniasis, and syphilis in adult @entity0 and @entity0 remain high, with nearly one million new infections with curable @entity3 each day. The estimates highlight the urgent need for the public health community to ensure that well-recognized effective interventions for @entity3 prevention, screening, diagnosis, and treatment are made more widely available. Improved estimation methods are needed to allow use of more varied data and generation of estimates at the national level.

title: Global Estimates of the Prevalence and Incidence of Four Curable XXXX in 2012 Based on Systematic Review and Global Reporting.

answer: @entity3


abstract: BACKGROUND: Renal transplantation (RTx) is the modality of choice for @entity2 due to @entity8 ( @entity8 ). The significance of ANCA positivity (ANCA+) at the time of RTx on recurrent disease is controversial. METHODS: We evaluated clinical outcomes and predictors of @entity6 in sixteen transplanted @entity8 @entity0 who were ANCA+ at RTx at a single University Medical Center. Allograft function, @entity6 , and predictors of @entity6 were assessed using descriptive statistics and logistic regression analysis. RESULTS: Our cohort had a median age of 64  years, 88  % Caucasians, 63  % males, 50  % @entity7 +. All @entity0 were in remission at the time of RTx. Twelve received induction therapy and all were on @entity3 , @entity1 and @entity5 . The mean (SD) serum @entity4 was 1.2 (0.3) mg/dl at 1  year and 1.8 (1.7) mg/dl at last follow up. Six developed @entity6 at post-transplant. All relapses were treated with escalation in immunosuppression. One non-compliant @entity0 suffered graft loss while the remaining @entity0 achieved remission. In adjusted logistic regression analysis, @entity7 ANCA+ @entity0 were two times (OR 2.19, p  =  0.71) more likely to experience a relapse compared to MPO ANCA+ @entity0 . CONCLUSIONS: This study demonstrates that @entity7 ANCA+ @entity0 may be more likely to experience relapse post-transplant. Further investigation of the predictors of @entity6 among @entity8 @entity0 who are ANCA+ at the time of RTx needs to be pursued.

title: Relevance of ANCA positivity at the time of renal transplantation in XXXX .

answer: @entity8


abstract: BACKGROUND: To determine the prognosis of a micropapillary (MP) pattern in @entity0 with @entity1 (SBOT). METHODS: Review of @entity0 with stage II and stage III SBOT treated or referred to our institution with characterization of an MP pattern and its clinical impact. RESULTS: In 1969-2006, 168 @entity0 were reviewed. Fifty-six @entity0 had @entity2 . The rate of conservative surgery was lower in the @entity2 group than in the typical SBOT group, but the rate of @entity0 with more than three peritoneal sites with implants was higher in the @entity2 group. The rate of invasive implants was not statistically different between the two groups. Eighteen recurrences were observed (six of them in the form of invasive disease) in the @entity2 group. Only one death was observed. The overall survival times and recurrence-free intervals were similar in both groups. The only prognostic factor for recurrence in the @entity2 group was the use of conservative surgery. CONCLUSIONS: In the present series, an MP pattern doesn't appear to signify a poor prognosis. The only prognostic factor for recurrence in @entity2 was the use of conservative surgery. Further studies on the MP pattern are needed to evaluate prognosis and the results of conservative surgery.

title: Prognosis and prognostic factors of the micropapillary pattern in @entity0 treated for stage II and III serous borderline XXXX of the ovary.

answer: @entity1


abstract: BACKGROUND: To determine the prognosis of a micropapillary (MP) pattern in @entity0 with @entity1 (SBOT). METHODS: Review of @entity0 with stage II and stage III SBOT treated or referred to our institution with characterization of an MP pattern and its clinical impact. RESULTS: In 1969-2006, 168 @entity0 were reviewed. Fifty-six @entity0 had @entity2 . The rate of conservative surgery was lower in the @entity2 group than in the typical SBOT group, but the rate of @entity0 with more than three peritoneal sites with implants was higher in the @entity2 group. The rate of invasive implants was not statistically different between the two groups. Eighteen recurrences were observed (six of them in the form of invasive disease) in the @entity2 group. Only one death was observed. The overall survival times and recurrence-free intervals were similar in both groups. The only prognostic factor for recurrence in the @entity2 group was the use of conservative surgery. CONCLUSIONS: In the present series, an MP pattern doesn't appear to signify a poor prognosis. The only prognostic factor for recurrence in @entity2 was the use of conservative surgery. Further studies on the MP pattern are needed to evaluate prognosis and the results of conservative surgery.

title: Prognosis and prognostic factors of the micropapillary pattern in XXXX treated for stage II and III serous borderline @entity1 of the ovary.

answer: @entity0


abstract: PURPOSE: To evaluate the effect of the introduction of digital mammography on the recall rate, detection rate, false-positive rate, and rates of invasive procedures in a cohort of @entity1 from four population-based @entity0 screening programs in Spain. MATERIALS AND METHODS: The study was approved by the ethics committee; informed consent was not required. A total of 242,838 mammograms (171,191 screen film [screen-film mammography group] and 71,647 digital [digital mammography group]) obtained in 103,613 @entity1 aged 45-69 years were included. False-positive results for any additional procedure and for invasive procedures, the @entity0 rate, and the positive predictive value in each group were compared by using Pearson   (2) test. The effect of the mammographic technology used (screen-film or digital) on the false-positive results and @entity2 detection risk was evaluated with multivariate logistic regression models, adjusted according to @entity1 's and the screening program's characteristics and time trends. RESULTS: The false-positive rate was higher for screen-film than for digital mammography (7.6% and 5.7%, respectively; P < .001). False-positive results after an invasive procedure were significantly higher for screen-film than for digital mammography (1.9% and 0.7%, respectively; P < .001). No significant differences were observed in the overall @entity2 detection rate between the two groups (0.45% and 0.43% in the screen-film and digital mammography groups, respectively; P = .59). The adjusted risk of a false-positive result was higher for screen-film than for digital mammography (odds ratio = 1.32). The adjusted risk was also lower for the digital mammography group when time trends were taken into account. CONCLUSION: The lower false-positive risk with use of digital mammography should be taken into account when balancing the risks and benefits of @entity0 screening.

title: Reduction in false-positive results after introduction of digital mammography: analysis from four population-based XXXX screening programs in Spain.

answer: @entity0


abstract: UNASSIGNED: A 51-year-old @entity0 was admitted to our hospital complaining of preceding throbbing @entity6 . @entity2 and convulsive @entity6 disappeared and his consciousness recovered to alert within 2 hours after onset. Neurological examination showed no abnormal findings. Laboratory examinations revealed high low-density lipoprotein @entity5 (179   mg/dL), @entity10 (42   ng/mL/hour), @entity14 (265   pg/mL), @entity12 (1031   pg/mL), and @entity11 (79   pg/mL). In brain magnetic resonance imaging (MRI), fluid-attenuated inversion recovery, but not the diffusion-weighted image, showed high signal intensities in white matter in bilateral occipital, parietal, and frontal lobes, with no stenotic changes on magnetic resonance angiography. In addition, the diffusion coefficient of focal lesions was elevated. Decreasing blood flow velocity and separated lumens in the right renal artery trunk were shown by renal artery ultrasonography. Enhanced computed tomography and renal angiography showed right renal partial @entity13 and @entity9 in the right renal artery, accompanied by thrombosed false lumen. No stenotic changes were seen in other peripheral arteries. These findings seemed incompatible with renal dissection and @entity16 , @entity18 , and @entity7 nodosa. Our diagnosis was @entity3 ( @entity3 ) induced by @entity17 due to @entity1 . To improve the @entity15 and secondary @entity4 , we performed @entity8 , in addition to administering antihypertensive and lipid-lowering medications. After angioplasty, @entity4 and high signal intensity at brain MRI were clearly improved. We would like to emphasize that renal artery angioplasty should be considered as an option for @entity0 with @entity3 and malignant @entity4 .

title: Percutaneous Transluminal Angioplasty Improved Posterior Reversible XXXX Syndrome due to Renovascular Hypertension.

answer: @entity3


abstract: OBJECTIVE: To compare a novel code-word alarm with a commercially available wireless alarm for treating @entity1 . SETTING: A tertiary paediatric centre. @entity0 : @entity0 aged 6-18 with at least 3   wet nights per week in the previous 6   months referred by doctors. OUTCOMES: Primary outcome: the proportion who achieved a full response (14 consecutive dry nights) by 16   weeks. SECONDARY OUTCOMES: change in frequency of wetting, duration of alarm training, percentage of wet nights that the @entity0 woke to the alarm, adherence to treatment, adverse events and satisfaction with treatment. RESULTS: Of the 353 @entity0 , 176 were assigned to the code-word alarm and 177 to control. At 16   weeks, 54% (95% CI 47% to 61%) in the experimental group and 47% (95% CI 40% to 55%) in the control group had achieved a full response (p=0.22), with 74% and 66%, respectively, attaining a 50% or more reduction in wetting frequency (p=0.14). The experimental group woke more often than the control group (median percentage of waking 88% vs 77%, p=0.003) and had a greater reduction in wet nights (median reduction of 10 vs 9 nights per fortnight). Fewer in the experimental group discontinued therapy before achieving a full response (27% vs 37% discontinued, p=0.04). There were no significant differences in relapse rates at 6   months, adverse events or satisfaction between the two alarms. CONCLUSIONS: Although the code-word alarm increased waking, no difference in full response rates was demonstrated between the two alarms. TRIAL REGISTRATION NUMBER: ACTRN12609000070235.

title: A randomised controlled trial of a code-word XXXX alarm.

answer: @entity1


abstract: BACKGROUND: @entity8 ( @entity5 ) is a @entity2 with a significant tendency to recur locally and rarely to produce pulmonary @entity1 . It is characterized by the presence of multinucleated osteoclast-like giant cells together with mononuclear spindle-shaped cells. Few prognostic markers have been reported to predict the clinical outcome of @entity5 @entity0 , so is very important to find the factor that can be implicated in its potential @entity3 . @entity0 AND METHODS: Different groups of @entity5 @entity0 were selected for this study, including @entity0 without evidence of disease and @entity0 who recurred locally or with lung metastasis. The total of 92 @entity2 samples also included the specimens of the local recurrences and the lung @entity1 . By using immunohistochemistry and real-time quantitative polymerase chain reaction techniques, the genetic and proteic analyses were performed on the @entity7 ( @entity7 ), its receptor ( @entity9 ) and its inhibitor ( @entity6 ), which have been described to be frequently implicated in the process of degradation of the extracellular matrix during the metastatic process. @entity4 ( @entity4 ), a cytokine released by @entity5 cells, which stimulates resorption of bone, was also analyzed. RESULTS: @entity4 , @entity7 , @entity9 and @entity6 genes were found amplified, respectively, in 7%, 5%, 8% and 12% of total cases (92). In particular, the percentages of amplified genes were higher in the @entity5 cells that gave rise to @entity1 (12 cases) and in the samples of lung @entity1 (nine cases) compared with the disease-free group of @entity0 (60 cases). CONCLUSIONS: These results suggest a possible association of these factors with a higher biological @entity3 of @entity5 . Morever, it appears that increased expression of the @entity4 , @entity7 , @entity9 and @entity6 proteins might not depend on mutation of the corresponding genes.

title: Proteases and XXXX gene analysis in 92 giant cell tumors of bone.

answer: @entity4


abstract: UNASSIGNED: Abnormalities in @entity1 neurotransmission may have a role in the pathophysiology of adolescent @entity0 . The present pilot study examined changes in cortical @entity1 / @entity1 ratios in @entity0 adolescents receiving high-frequency repetitive transcranial magnetic stimulation. Ten adolescents with treatment-refractory major @entity0 received up to 30 sessions of 10-Hz repetitive transcranial magnetic stimulation at 120% motor threshold with 3000 pulses per session applied to the left dorsolateral prefrontal cortex. Baseline, posttreatment, and 6-month follow-up proton magnetic resonance spectroscopy scans of the anterior cingulate cortex and left dorsolateral prefrontal cortex were collected at 3T with 8-cm(3) voxels. @entity1 metabolites were quantified with 2 distinct proton magnetic resonance spectroscopy sequences in each brain region. After repetitive transcranial magnetic stimulation and at 6 months of follow-up, @entity1 / @entity1 ratios increased in the anterior cingulate cortex and left dorsolateral prefrontal cortex with both measurements. The increase in the @entity1 / @entity1 ratio reached statistical significance with the TE-optimized PRESS sequence in the anterior cingulate cortex. @entity1 / @entity1 ratios increased in conjunction with depressive symptom improvement. This reached statistical significance with the TE-optimized PRESS sequence in the left dorsolateral prefrontal cortex. High-frequency repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex may modulate @entity1 neurochemistry in @entity0 adolescents.

title: Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in XXXX adolescents.

answer: @entity0


abstract: Disturbed sleep cycles are the principal cause of institutionalization in @entity2 , and therefore represent a major clinical problem. They may arise from dysfunction within the circadian clock of the hypothalamus that times and consolidates wakefulness, or from neuropathology in output pathways and/or target sites of the clock specifically controlling sleep and wakefulness. To determine the relationship of disturbed activity cycles to other circadian clock-controlled rhythms, cross-sectional and longitudinal actigraphy and serial sampling of saliva were used to compare the impact of early @entity1 on activity/rest and @entity4 rhythms in home-dwelling subjects. Mildly demented subjects had daily activity rhythms comparable to those of healthy age-matched subjects. Moderately demented subjects exhibited a range of disturbances of the activity/rest cycle, with reduced stability, @entity5 and @entity3 . Within the moderately demented group, however, the degree of circadian disruption was not correlated with the individual severity of @entity2 . All groups of subjects, mild, moderate with normal activity cycles and moderate with abnormal activity cycles, exhibited robust daily profiles of salivary @entity4 , with highest levels in the morning (08:00 h) and an evening nadir (20:00-24:00 h). Salivary @entity4 levels tended to be higher in the moderately demented subjects in the afternoon, but this effect was not specific to those with abnormal activity/rest patterns. The actimetric data confirm that deterioration of activity/rest cycles is a common and progressive feature in home-dwelling Alzheimer's @entity0 , occurring early in the disease but after the measurable onset of @entity2 . The maintenance of highly rhythmic daily @entity4 profiles in association with disturbed activity profiles, both on an individual and on a group basis, demonstrates that loss of circadian control to activity/rest cycles is not a consequence of global circadian disruption in early @entity2 . Rather, pathology may develop in discrete elements of the circadian clockwork and/or its output systems that control activity/rest, sleep and wakefulness. Further characterization of this pathology will facilitate more effective management of sleep patterns in home-dwelling demented @entity0 .

title: Disrupted daily activity/rest cycles in relation to daily @entity4 rhythms of home-dwelling @entity0 with early XXXX .

answer: @entity1


abstract: Disturbed sleep cycles are the principal cause of institutionalization in @entity2 , and therefore represent a major clinical problem. They may arise from dysfunction within the circadian clock of the hypothalamus that times and consolidates wakefulness, or from neuropathology in output pathways and/or target sites of the clock specifically controlling sleep and wakefulness. To determine the relationship of disturbed activity cycles to other circadian clock-controlled rhythms, cross-sectional and longitudinal actigraphy and serial sampling of saliva were used to compare the impact of early @entity1 on activity/rest and @entity4 rhythms in home-dwelling subjects. Mildly demented subjects had daily activity rhythms comparable to those of healthy age-matched subjects. Moderately demented subjects exhibited a range of disturbances of the activity/rest cycle, with reduced stability, @entity5 and @entity3 . Within the moderately demented group, however, the degree of circadian disruption was not correlated with the individual severity of @entity2 . All groups of subjects, mild, moderate with normal activity cycles and moderate with abnormal activity cycles, exhibited robust daily profiles of salivary @entity4 , with highest levels in the morning (08:00 h) and an evening nadir (20:00-24:00 h). Salivary @entity4 levels tended to be higher in the moderately demented subjects in the afternoon, but this effect was not specific to those with abnormal activity/rest patterns. The actimetric data confirm that deterioration of activity/rest cycles is a common and progressive feature in home-dwelling Alzheimer's @entity0 , occurring early in the disease but after the measurable onset of @entity2 . The maintenance of highly rhythmic daily @entity4 profiles in association with disturbed activity profiles, both on an individual and on a group basis, demonstrates that loss of circadian control to activity/rest cycles is not a consequence of global circadian disruption in early @entity2 . Rather, pathology may develop in discrete elements of the circadian clockwork and/or its output systems that control activity/rest, sleep and wakefulness. Further characterization of this pathology will facilitate more effective management of sleep patterns in home-dwelling demented @entity0 .

title: Disrupted daily activity/rest cycles in relation to daily XXXX rhythms of home-dwelling @entity0 with early @entity1 .

answer: @entity4


abstract: Disturbed sleep cycles are the principal cause of institutionalization in @entity2 , and therefore represent a major clinical problem. They may arise from dysfunction within the circadian clock of the hypothalamus that times and consolidates wakefulness, or from neuropathology in output pathways and/or target sites of the clock specifically controlling sleep and wakefulness. To determine the relationship of disturbed activity cycles to other circadian clock-controlled rhythms, cross-sectional and longitudinal actigraphy and serial sampling of saliva were used to compare the impact of early @entity1 on activity/rest and @entity4 rhythms in home-dwelling subjects. Mildly demented subjects had daily activity rhythms comparable to those of healthy age-matched subjects. Moderately demented subjects exhibited a range of disturbances of the activity/rest cycle, with reduced stability, @entity5 and @entity3 . Within the moderately demented group, however, the degree of circadian disruption was not correlated with the individual severity of @entity2 . All groups of subjects, mild, moderate with normal activity cycles and moderate with abnormal activity cycles, exhibited robust daily profiles of salivary @entity4 , with highest levels in the morning (08:00 h) and an evening nadir (20:00-24:00 h). Salivary @entity4 levels tended to be higher in the moderately demented subjects in the afternoon, but this effect was not specific to those with abnormal activity/rest patterns. The actimetric data confirm that deterioration of activity/rest cycles is a common and progressive feature in home-dwelling Alzheimer's @entity0 , occurring early in the disease but after the measurable onset of @entity2 . The maintenance of highly rhythmic daily @entity4 profiles in association with disturbed activity profiles, both on an individual and on a group basis, demonstrates that loss of circadian control to activity/rest cycles is not a consequence of global circadian disruption in early @entity2 . Rather, pathology may develop in discrete elements of the circadian clockwork and/or its output systems that control activity/rest, sleep and wakefulness. Further characterization of this pathology will facilitate more effective management of sleep patterns in home-dwelling demented @entity0 .

title: Disrupted daily activity/rest cycles in relation to daily @entity4 rhythms of home-dwelling XXXX with early @entity1 .

answer: @entity0


abstract: BACKGROUND: @entity1 results from co-inheritance of two mutant beta-globin alleles. Allogeneic cord blood cell transplantation (CBT) from an HLA-identical sibling donor is an excellent treatment option for @entity1 . In families with an affected @entity0 and willing to have another @entity0 , IVF followed by preimplantation genetic diagnosis (PGD) can be applied to exclude affected embryos. Furthermore, healthy embryos could be HLA matched with the affected @entity0 so that cord blood from the future newborn can be used to transplant the affected sibling. METHODS: We developed an indirect single-cell HLA typing technique based on the use of a bank of seven microsatellite markers within the HLA locus from which four informative and evenly distributed markers were selected. RESULTS: The methodology was validated in three @entity1 families having six ovarian stimulation cycles in view of IVF and PGD. Six PGD cycles were performed in two families. On 58 embryos tested, the combined PCR was successful in 54 (93%). Two transfers were done and one clinical pregnancy was obtained. Using confirmatory analysis on 50 embryos, the accuracy for HLA typing was 100%. CONCLUSION: This strategy offers a new therapeutic option for @entity0 with @entity1 and other monogenic diseases that can be cured with CBT.

title: Novel universal approach for preimplantation genetic diagnosis of XXXX in combination with HLA matching of embryos.

answer: @entity1


abstract: This is a personal clinical and radiological follow-up of 65 @entity0 with @entity4 who were treated in 1973 to 1984 at our hospital. 30 @entity0 were operated by nailing according to Smith-Petersen and in 35 @entity0 osteosynthesis was performed by means of three or four lag screws. A comparative study between these two methods was done. The two main complications of @entity4 , a vascular @entity1 and @entity3 , were of special interest. The mean follow-up time was 7.2 years with the @entity2 fixed by nailing and 4.1 years, with the @entity2 operated by lag screws. Out of the 65 @entity0 the total rate of femoral head necroses was 21.5% and 10.7% of @entity3 . In the @entity2 treated by the nailing method the rate of @entity1 was 23.3% and the rate of @entity3 13.3%. In the @entity2 operated by lag screws the incidence of @entity1 was 20% and 8.5% by @entity3 . @entity2 was primarily responsible for the development of @entity1 , but we could see also a relation between @entity1 and the inclination of the @entity2 line. Fractures of the type PIII/GIII/IV are those with the highest rate of @entity5 . Furthermore, the development of both, @entity1 and @entity3 , is strongly influenced by incomplete reduction.

title: [Comparative results of compression and non-compression operation methods following medial XXXX ].

answer: @entity4


abstract: BACKGROUND: The aim of this study was to determine the activity of the combination of @entity8 , @entity2 and @entity10 ( @entity10 ) as therapy for metastatic or locally advanced inoperable @entity6 . @entity0 AND METHODS: @entity0 with histologically proven advanced or metastatic @entity6 received first-line chemotherapy comprising @entity8 (20 mg/m2 on days 1, 8, 15, 22, 29 and 36), @entity2 (1000 mg/m2 on days 1, 8, 29 and 36) and @entity10 (200 mg/m2 as continuous infusion on days 1-42) every 56 days. RESULTS: A total of 34 @entity0 were studied. Eighty courses were administered (median two courses per @entity0 ). Among 32 @entity0 evaluable for response, two @entity0 had a complete response and four a partial response for an overall response rate of 19% (95% confidence interval 7% to 36%). Thirteen @entity0 had stable disease (40%) and 13 progressed. Median progression-free survival was 4.7 months, median survival 9.0 months and 26% of @entity0 achieved 1-year survival. Ten of 25 @entity0 (40%) with @entity4 at presentation had a sustained reduction of analgesic consumption. The principal grade 3/4 @entity3 were @entity9 , @entity7 , @entity5 and @entity1 , occurring in 24%, 21%, 9% and 3% of @entity0 . CONCLUSION: This schedule seems well tolerated and active in @entity6 and worthwhile of further evaluation.

title: Phase II study of XXXX , @entity2 and @entity10 in advanced @entity6 .

answer: @entity8


abstract: BACKGROUND: The aim of this study was to determine the activity of the combination of @entity8 , @entity2 and @entity10 ( @entity10 ) as therapy for metastatic or locally advanced inoperable @entity6 . @entity0 AND METHODS: @entity0 with histologically proven advanced or metastatic @entity6 received first-line chemotherapy comprising @entity8 (20 mg/m2 on days 1, 8, 15, 22, 29 and 36), @entity2 (1000 mg/m2 on days 1, 8, 29 and 36) and @entity10 (200 mg/m2 as continuous infusion on days 1-42) every 56 days. RESULTS: A total of 34 @entity0 were studied. Eighty courses were administered (median two courses per @entity0 ). Among 32 @entity0 evaluable for response, two @entity0 had a complete response and four a partial response for an overall response rate of 19% (95% confidence interval 7% to 36%). Thirteen @entity0 had stable disease (40%) and 13 progressed. Median progression-free survival was 4.7 months, median survival 9.0 months and 26% of @entity0 achieved 1-year survival. Ten of 25 @entity0 (40%) with @entity4 at presentation had a sustained reduction of analgesic consumption. The principal grade 3/4 @entity3 were @entity9 , @entity7 , @entity5 and @entity1 , occurring in 24%, 21%, 9% and 3% of @entity0 . CONCLUSION: This schedule seems well tolerated and active in @entity6 and worthwhile of further evaluation.

title: Phase II study of @entity8 , @entity2 and @entity10 in advanced XXXX .

answer: @entity6


abstract: BACKGROUND: The aim of this study was to determine the activity of the combination of @entity8 , @entity2 and @entity10 ( @entity10 ) as therapy for metastatic or locally advanced inoperable @entity6 . @entity0 AND METHODS: @entity0 with histologically proven advanced or metastatic @entity6 received first-line chemotherapy comprising @entity8 (20 mg/m2 on days 1, 8, 15, 22, 29 and 36), @entity2 (1000 mg/m2 on days 1, 8, 29 and 36) and @entity10 (200 mg/m2 as continuous infusion on days 1-42) every 56 days. RESULTS: A total of 34 @entity0 were studied. Eighty courses were administered (median two courses per @entity0 ). Among 32 @entity0 evaluable for response, two @entity0 had a complete response and four a partial response for an overall response rate of 19% (95% confidence interval 7% to 36%). Thirteen @entity0 had stable disease (40%) and 13 progressed. Median progression-free survival was 4.7 months, median survival 9.0 months and 26% of @entity0 achieved 1-year survival. Ten of 25 @entity0 (40%) with @entity4 at presentation had a sustained reduction of analgesic consumption. The principal grade 3/4 @entity3 were @entity9 , @entity7 , @entity5 and @entity1 , occurring in 24%, 21%, 9% and 3% of @entity0 . CONCLUSION: This schedule seems well tolerated and active in @entity6 and worthwhile of further evaluation.

title: Phase II study of @entity8 , @entity2 and XXXX in advanced @entity6 .

answer: @entity10


abstract: BACKGROUND: The aim of this study was to determine the activity of the combination of @entity8 , @entity2 and @entity10 ( @entity10 ) as therapy for metastatic or locally advanced inoperable @entity6 . @entity0 AND METHODS: @entity0 with histologically proven advanced or metastatic @entity6 received first-line chemotherapy comprising @entity8 (20 mg/m2 on days 1, 8, 15, 22, 29 and 36), @entity2 (1000 mg/m2 on days 1, 8, 29 and 36) and @entity10 (200 mg/m2 as continuous infusion on days 1-42) every 56 days. RESULTS: A total of 34 @entity0 were studied. Eighty courses were administered (median two courses per @entity0 ). Among 32 @entity0 evaluable for response, two @entity0 had a complete response and four a partial response for an overall response rate of 19% (95% confidence interval 7% to 36%). Thirteen @entity0 had stable disease (40%) and 13 progressed. Median progression-free survival was 4.7 months, median survival 9.0 months and 26% of @entity0 achieved 1-year survival. Ten of 25 @entity0 (40%) with @entity4 at presentation had a sustained reduction of analgesic consumption. The principal grade 3/4 @entity3 were @entity9 , @entity7 , @entity5 and @entity1 , occurring in 24%, 21%, 9% and 3% of @entity0 . CONCLUSION: This schedule seems well tolerated and active in @entity6 and worthwhile of further evaluation.

title: Phase II study of @entity8 , XXXX and @entity10 in advanced @entity6 .

answer: @entity2


abstract: Forty-one @entity0 (30 males, 11 females; mean age 49.7 years) with diagnosis of the "non-oat cell" type of @entity1 were studied. All @entity0 were included in a randomized treatment design (regimens A and B) and completed six full cycles of polychemotherapy. Only 28 of the 41 @entity0 proved evaluable. The performance status was 0-2 in 20 subjects (71.4%) and 3-4 in 8 (28.6%). The total number of @entity0 achieving partial and complete responses was 20 (71.4%), of whom 14 (70%) received CDDP and the other 6 DDR. A progression of the disease was seen in 8 @entity0 (28.6%), of whom 5 (62.5%) received DDR and the other 3 (37.5%) CDDP. An increase in body weight (3-8 kg) was observed in 15 @entity0 (53.6%). Twenty-four of the 28 @entity0 (85.7%) had a subjective feeling of well-being throughout the 6 cycles of chemotherapy. @entity3 and @entity4 and @entity7 were the most frequent side-effects. The most important complications were @entity9 in 2 cases and a darkish manifestation in forearm and hand tissue due to @entity8 extravasation in another 2 cases. @entity2 was found to be acceptable: @entity6 (less than 3.000) in 30 @entity0 (73.2%); and @entity5 (less than 100.000) in 12 @entity0 (29.2%), which proved reversible. Some modalities relative to treatment schemes and the incorporation of additional agents are discussed.

title: Combined polychemotherapy in the treatment of primitive XXXX of the "non-oat cell" type.

answer: @entity1


abstract: BACKGROUND: @entity12 ( @entity12 ) cDNA was recently cloned from the @entity0 placenta, where it is expressed in syncytiotrophoblast and decidual mononuclear cells. @entity12 and its subcloned bioactive domain (C48), expressed in @entity5 , are immunosuppressive proteins and induce pronounced @entity10 production in vitro and in vivo. METHODS AND RESULTS: @entity12 serum level, measured by enzyme-linked immunosorbent assay, was elevated in pregnant @entity1 throughout gestation and declined towards delivery. Blocking of @entity12 activity by vaccination of @entity1 with C48 prior to mating inhibited pregnancy development. Passive transfer of anti-C48 immunoglobulin (Ig) starting at 3.5-12.5 days post coitum (dpc) resulted in high rate of embryo resorption. Furthermore, treatment with anti-C48 Ig resulted in placental and embryonal growth restriction. At gestation day 13.5, @entity9 was especially notable in the placentae, while at 16.5 dpc it was pronounced in the embryos. Histopathological examination revealed that experimental placentae were globally hypoplastic and the labyrinth was strikingly pale and contained less maternal blood compared with control. Immune-activated spleen cells harvested at 13.5 dpc from anti-C48 Ig-treated pregnant @entity1 secreted in vitro increased level of @entity6 cytokines ( @entity11 , @entity7 , IL-12) and decreased level of @entity4 cytokines ( @entity10 , @entity2 , @entity3 , @entity8 ) as compared with the level of the respective cytokines secreted by spleen cells from control pregnant @entity1 . CONCLUSION: This study provides the first in vivo evidence that @entity12 plays a major role in placentation and embryonic growth.

title: Blocking of the placental immune-modulatory ferritin activates XXXX type cytokines and affects placenta development, fetal growth and the pregnancy outcome.

answer: @entity6


abstract: OBJECTIVE: To determine the long-term outcomes of @entity0 with locally advanced @entity4 (LAEC) who underwent esophagectomy and survived at least 5  years, and the predictors of disease-free survival (DFS) beyond 5  years. METHODS: This was a retrospective review of a prospective database to identify @entity0 with clinical stage T2N0M0 or higher LAEC. Medical records were reviewed to obtain demographic, clinical, and pathological characteristics, as well as data on recurrence and survival. Multivariable analysis of predictors of DFS beyond 5  years was performed using a Cox regression model. RESULTS: Between 1988 and 2009, 355 of 500 @entity0 underwent esophagectomy for cT2N0M0 or higher disease. Of these 355 @entity0 , 126 were alive and disease-free at the 5-year follow-up, for an actuarial 5-year DFS of 33%. Recurrent @entity4 developed in 8 @entity0 after 5  years. Among the 126 surviving @entity0 , the actuarial overall survival was 94% at 7  years and 80% at 10  years. On multivariable analysis, the sole significant predictor of DFS after the 5-year time point was non-en bloc resection at the original operation (P  =  .006). Pulmonary-related @entity2 accounted for 10 out of 22 noncancer @entity2 . A second @entity1 developed in 23 of the 126 surviving @entity0 . CONCLUSIONS: Prolonged survival can be obtained in one-third of @entity0 with LAEC. An en bloc resection at the original operation is the most significant predictor of prolonged survival. Survivors experience a high rate of second @entity1 and an apparently high rate of @entity2 from @entity3 . Careful follow-up is necessary for these @entity0 , even after the 5-year mark.

title: Locally advanced XXXX : What becomes of 5-year survivors?

answer: @entity4


abstract: Digital subtraction angiography (DSA) has been confirmed to be an accurate method for determining left ventricular function. It is a relatively non-invasive technique without inducing @entity5 . The response of left ventricular function to afterload stress was assessed using DSA for eight @entity0 with old anterior @entity2 and @entity1 including that of the anterior wall (averaging 30.3 months after the acute episodes). Their ages ranged from 36 to 65 years and one @entity0 was a @entity0 . Prior to the investigation, we confirmed that a single DSA procedure did not alter left ventricular function in a pilot study of one @entity0 (No. 8). After initial DSA in the basal state, @entity6 was infused intravenously (1 to 2 mg/min). When aortic systolic blood pressure increased by 30 to 50 mmHg, a second DSA was performed for each @entity0 . Left ventricular volumes and ejection fractions were calculated by the area-length method, and regional wall motion was assessed by the visual method according to the AHA classification and the curvature radius of the @entity1 was calculated. @entity6 induced neither @entity3 nor @entity4 in the present series. The heart rates decreased, and there were a significant increase in end-systolic volumes (p less than 0.05), end-systolic radii (p less than 0.05), and a significant decrease in ejection fractions (p less than 0.02) after @entity6 infusion. In 32 of 40 segments, regional wall motion was unchanged by @entity6 as assessed by the visual method; whereas, in the other eight, there was a deterioration.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Functional reserve of the ischemic left ventricle with XXXX to afterload stress: digital subtraction angiographic assessments].

answer: @entity1


abstract: PURPOSE: Studies have found disparities in @entity2 between lesbian and gay @entity0 survivors and their heterosexual counterparts. Exercise and partner support are shown to reduce distress. However, exercise interventions haven't been delivered to lesbian and gay survivors with support by caregivers included. METHODS: In this pilot randomized controlled trial (RCT), ten lesbian and gay and twelve heterosexual survivors and their caregivers were randomized as dyads to: @entity3 , a survivor-only, 6-week, home-based, aerobic and resistance training program (EXCAP(    )); or @entity4 , a dyadic version of the same exercise program involving both the survivor and caregiver. Psychological distress, partner support, and exercise adherence, were measured at baseline and post-intervention (6 weeks later). We used t-tests to examine group differences between lesbian/gay and heterosexual survivors and between those randomized to survivor-only or @entity5 . RESULTS: Twenty of the twenty-two recruited survivors were retained post-intervention. At baseline, lesbian and gay survivors reported significantly higher @entity1 (P   =   .03) and fewer average steps walked (P   =   .01) than heterosexual survivors. Post-intervention, these disparities were reduced and we detected no significant differences between lesbian/gay and heterosexual survivors. Participation in @entity5 resulted in a significantly greater reduction in @entity1 than participation in survivor-only exercise for all survivors (P   =   .03). No statistically significant differences emerged when looking across arm (survivor-only vs. dyadic) by subgroup (lesbian/gay vs. heterosexual). CONCLUSION: Exercise may be efficacious in ameliorating disparities in @entity2 among lesbian and gay @entity0 survivors, and @entity5 may be efficacious for survivors of diverse sexual orientations. Larger trials are needed to replicate these findings.

title: A Dyadic Exercise Intervention to Reduce Psychological Distress Among Lesbian, Gay, and XXXX .

answer: @entity0


abstract: INTRODUCTION: Quantitative electrocardiographic (ECG) waveform analysis provides a noninvasive reflection of the metabolic milieu of the myocardium during resuscitation and is a potentially useful tool to optimize the defibrillation strategy. However, whether combining multiple ECG features can improve the capability of defibrillation outcome prediction in comparison to single feature analysis is still uncertain. METHODS: A total of 3828 defibrillations from 1617 @entity0 who experienced out-of-hospital @entity1 were analyzed. A 2.048-s ECG trace prior to each defibrillation without chest compressions was used for the analysis. Sixteen predictive features were optimized through the training dataset that included 2447 shocks from 1050 @entity0 . Logistic regression, neural network and support vector machine were used to combine multiple features for the prediction of defibrillation outcome. Performance between single and combined predictive features were compared by area under receiver operating characteristic curve (AUC), sensitivity, specificity, positive predictive value ( @entity2 ), negative predictive value (NPV), and prediction accuracy (PA) on a validation dataset that consisted of 1381 shocks from 567 @entity0 . RESULTS: Among the single features, mean slope (MS) outperformed other methods with an AUC of 0.876. Combination of complementary features using neural network resulted in the highest AUC of 0.874 among the multifeature-based methods. Compared to MS, no statistical difference was observed in AUC, sensitivity, specificity, @entity2 , NPV and PA when multiple features were considered. CONCLUSIONS: In this large dataset, the amplitude-related features achieved better defibrillation outcome prediction capability than other features. Combinations of multiple electrical features did not further improve prediction performance.

title: Combining multiple ECG features does not improve prediction of defibrillation outcome compared to single features in a large population of out-of-hospital XXXX .

answer: @entity1


abstract: Unstable pelvic ring injuries @entity3 ("vertical shear") with a @entity2 are treated operatively in less than 50% of the cases (DGU pelvis study group). Furthermore, only 12% of these ORIF involve the sacrum bone itself. No specific technique has gained wide acceptance in treating transsacral instability. In accordance with earlier publications (K  ch, Josten) suggesting an internal fixator, we developed the dorsal sacrum fracture distantly anchored ORIF (DSDO). This procedure closes the dorsal pelvic ring by joining the two dorsal iliac crests (fixed-angle screws inserted in the posterior superior iliac spine) and additionally anchors in a lumbar pedicle. Thus, a three-dimensional reduction and stable fixation device with optional local nerve decompression and even plating possibility is achieved. Between January 1996 and July 2001, 35 unstable sacrum disruptions were treated with DSDO in 180 @entity0 operated for pelvic @entity1 . This allowed immediate mobilization in all cases. The radiologic follow-up examination ( n=20) revealed a solid union in all @entity0 . Complications focused on management of the soft tissue degloving injury (Morel-Lavalle   lesion), which needs special attention.

title: [Therapy of unstable sacrum fractures in XXXX with dorsal sacrum distraction osteosynthesis].

answer: @entity2


abstract: @entity4 of the proximal hamstring muscles at the ischial tuberosity are rare injuries in sports. The trigger is usually an indirect @entity1 with overstretching of the ischiocrural muscles. In 8 @entity0 , the @entity4 tendons were anatomically refixed using a suture anchor system. 6 @entity0 were treated within 3 weeks after @entity1 , while 2 @entity0 were operated after delayed diagnosis of more than 2 months. The follow-up was on average 25.8 (5-52) months. After rehabilitation, five @entity0 returned to their preinjury sports level within 9-15 months on average. Indeed, 2 @entity0 (1 primary and 1 delayed operative management) also participated in sports activities in this period of time, but could not reach their preinjury sports level completely. 1 elite athlete was still in the rehabilitation program at 5 months of individual follow-up. @entity3 was 1 revision because of a suture anchor dislocation after improper use of the orthosis. In four @entity0 , incisional @entity2 and discomfort lasting up to 2 years were noticed. In case of early diagnosis, operative treatment especially in athletically ambitious @entity0 is the gold standard for complete @entity4 of the proximal hamstring tendons. The use of a suture anchor system represents an elegant and effective technique for the treatment of @entity4 of the proximal hamstring tendon complex.

title: [Refixation of complete tendon XXXX of proximal ischio-crural muscles].

answer: @entity4


abstract: UNASSIGNED: The Masquelet technique for the treatment of large bone defects consists of a 2-stage procedure. In the first stage, a polymethylmethacrylate (PMMA) cement spacer is inserted into the bony defect of a @entity0 's femur and over a period of 2-4 weeks a membrane forms that encapsulates the defect/spacer. In a second operation the membrane is opened, the PMMA spacer is removed and the resulting cavity is filled with autologous bone. Different kinds of bone cements are available, with or without supplemental antibiotics. Both might influence the development and the characteristics of the induced membrane which might affect the @entity1 response. Hence, this comparative study was performed to elucidate the effect of different bone cements with or without supplemental antibiotics on the development of an induced membrane in a critical size femur defect model in @entity0 . A total of 72 male SD @entity0 received a 10mm critical size defect of the femur which was stabilised by a plate osteosynthesis and filled with either Palacos+ @entity2 , @entity5 @entity2 + @entity3 , @entity5 + @entity2 + @entity4 or @entity5 Spacem. The induced membranes were analysed after two, four and six weeks (wks) after insertion of the cement spacers (n=6/group). Paraffin embedded histological sections of the membrane were microscopically analysed for membrane thickness, elastic fibres, vascularisation and proliferation by an independent observer blinded to the group setup. The thickness of the induced membrane increased significantly from 2 wks (553 m) to 6 wks (774 m) in group Palacos+ @entity2 whereas membrane thickness decreased significantly in groups @entity5 + @entity2 + @entity4 (682-329 m) and @entity5 Spacem (916 m to 371 m). The comparison between the groups revealed significantly increased membrane thickness in group Palacos+ @entity2 and @entity5 @entity2 + @entity3 in comparison to group @entity5 + @entity2 + @entity4 six weeks after induction. However, the fraction of elastic fibres was significantly increased in groups @entity5 + @entity2 + @entity4 (71%, 80%) and @entity5 Spacem (82%, 81%) after 2 and 4 weeks in comparison to the groups Palacos+ @entity2 (56%, 57%) and @entity5 @entity2 + @entity3 (63%, 69%). Those differences however were partly diminished after 6 wks. The ratio of immature (vWF+) to more mature (CD31+) blood vessels increased significantly in groups Palacos+ @entity2 and @entity5 @entity2 + @entity3 whereas no significant alterations were noted in groups @entity5 + @entity2 + @entity4 and @entity5 Spacem. For the first time we demonstrated that thickness and proportion of elastic fibres in induced membranes were influenced by the type of cement and the kind of supplemental antibiotics being used. Whether these alterations of the induced membrane have an effect on @entity1 remains to be proven in future studies.

title: Alteration of Masquelet's induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the XXXX 's femur.

answer: @entity0


abstract: A randomized clinical study of irradiation and irradiation combined with ACNU in the treatment of @entity2 was performed in order to determine if there was an enhancing therapeutic effect of ACNU given in addition to radiotherapy. An effect was defined as a reduction in @entity1 size, changes in neurological signs and performance status within 1 month after the completion of radiotherapy, or statistically improved survival times. Seventy-seven @entity0 from 14 neurosurgical clinics were included in this validated study group. Radiotherapy with a total dose of 5000 to 6000 rads, given in 25 to 30 subdoses, was applied to the whole brain and to a generous field surrounding the @entity1 . @entity0 who were assigned to receive chemotherapy were given ACNU intravenously once or twice during radiotherapy at a dose of 100 mg/sq m of body surface area. The response rate (more than 50% reduction of the @entity1 size) was 13.5% in the group treated by radiotherapy alone and 47.5% in the group with radiotherapy and ACNU. The hematological @entity3 was more severe in the group treated with radiotherapy and ACNU. Other @entity3 was mild and acceptable. The survival rates of @entity0 with @entity5 grade III and @entity4 multiforme at 36 months after the surgery were 48.9% and 0% for radiotherapy alone and 59.0% and 16.3% for radiotherapy plus ACNU, respectively. The differences between the survival curves were not significant at the p = 0.05 level. This study has demonstrated that, although the use of @entity6 during radiotherapy suppressed @entity2 more than radiotherapy alone, the survival time was not extended significantly. It is necessary to continue to search for an effective chemotherapeutic regimen to prolong survival of @entity0 with @entity2 .

title: Effects of ACNU and radiotherapy on XXXX .

answer: @entity2


abstract: OBJECTIVES: Recent evidence indicates that @entity5 is associated with the presence of autoantibodies capable of activating the angiotensin II receptor, @entity7 . We sought to evaluate the role of @entity7 agonistic autoantibodies ( @entity7 -AA) in two major features of @entity5 -increased @entity6 ( @entity6 ) production and shallow trophoblast invasion. METHODS: This study included 38 pregnant @entity0 , 20 of whom had severe @entity5 and 18 normotensive individuals. Immunoglobulin (Ig)G was purified from these individuals, and the presence of @entity7 -AA was determined based on its ability to stimulate an increase in the contraction rate of cultured @entity1 neonatal cardiac myocytes. Immortalized @entity0 trophoblasts were chosen to study @entity6 production and secretion after treatment with IgG from normotensive and preeclamptic @entity0 . An in vitro Matrigel invasion assay was used to test the effect of @entity7 -AA on the invasive properties of @entity0 trophoblasts. @entity8 and @entity2 were used to determine whether the @entity7 -AA-induced stimulation of @entity6 secretion is through the @entity7 receptor and the calcineurin-nuclear factor of activated t-cells (NFAT)-dependent pathway. RESULTS: The results show that IgG from 18 of 20 severely preeclamptic @entity0 stimulated increased cardiomyocyte contraction rates of 20-40 beats per minute. A significant stimulation of @entity6 secretion from @entity0 trophoblasts was observed with IgG from the same 18 of 20 @entity0 with severe @entity5 . Of IgG obtained from 18 normotensive pregnant @entity0 , only two showed a relatively low level of biologic activity in the cardiomyocyte contraction and @entity6 secretion assays. Activation of @entity7 receptors by @entity7 -AA was blocked by @entity8 (an @entity7 receptor antagonist) and by a seven @entity4 peptide corresponding to a sequence present on the second extracellular loop of the @entity7 receptor. Activation of @entity7 receptors by @entity7 -AA resulted in decreased trophoblast invasiveness as determined by the in vitro Matrigel invasion assay. Additional data indicate that @entity7 receptor activation by @entity7 -AA is followed by the downstream activation of the @entity3 -dependent calcineurin-NFAT signaling pathway leading to increased @entity6 gene expression. CONCLUSION: Our findings suggest that maternal autoantibody with the ability to activate @entity7 receptors may account for two features of @entity5 , increased @entity6 production and shallow trophoblast invasion.

title: Maternal autoantibodies from preeclamptic XXXX activate angiotensin receptors on @entity0 trophoblast cells.

answer: @entity0


abstract: OBJECTIVES: Recent evidence indicates that @entity5 is associated with the presence of autoantibodies capable of activating the angiotensin II receptor, @entity7 . We sought to evaluate the role of @entity7 agonistic autoantibodies ( @entity7 -AA) in two major features of @entity5 -increased @entity6 ( @entity6 ) production and shallow trophoblast invasion. METHODS: This study included 38 pregnant @entity0 , 20 of whom had severe @entity5 and 18 normotensive individuals. Immunoglobulin (Ig)G was purified from these individuals, and the presence of @entity7 -AA was determined based on its ability to stimulate an increase in the contraction rate of cultured @entity1 neonatal cardiac myocytes. Immortalized @entity0 trophoblasts were chosen to study @entity6 production and secretion after treatment with IgG from normotensive and preeclamptic @entity0 . An in vitro Matrigel invasion assay was used to test the effect of @entity7 -AA on the invasive properties of @entity0 trophoblasts. @entity8 and @entity2 were used to determine whether the @entity7 -AA-induced stimulation of @entity6 secretion is through the @entity7 receptor and the calcineurin-nuclear factor of activated t-cells (NFAT)-dependent pathway. RESULTS: The results show that IgG from 18 of 20 severely preeclamptic @entity0 stimulated increased cardiomyocyte contraction rates of 20-40 beats per minute. A significant stimulation of @entity6 secretion from @entity0 trophoblasts was observed with IgG from the same 18 of 20 @entity0 with severe @entity5 . Of IgG obtained from 18 normotensive pregnant @entity0 , only two showed a relatively low level of biologic activity in the cardiomyocyte contraction and @entity6 secretion assays. Activation of @entity7 receptors by @entity7 -AA was blocked by @entity8 (an @entity7 receptor antagonist) and by a seven @entity4 peptide corresponding to a sequence present on the second extracellular loop of the @entity7 receptor. Activation of @entity7 receptors by @entity7 -AA resulted in decreased trophoblast invasiveness as determined by the in vitro Matrigel invasion assay. Additional data indicate that @entity7 receptor activation by @entity7 -AA is followed by the downstream activation of the @entity3 -dependent calcineurin-NFAT signaling pathway leading to increased @entity6 gene expression. CONCLUSION: Our findings suggest that maternal autoantibody with the ability to activate @entity7 receptors may account for two features of @entity5 , increased @entity6 production and shallow trophoblast invasion.

title: Maternal autoantibodies from preeclamptic @entity0 activate angiotensin receptors on XXXX trophoblast cells.

answer: @entity0


abstract: Acute @entity4 was found to be less common in black @entity0 than in white @entity0 in the Johannesburg area of South Africa. Of 195 consecutive @entity0 , 78 were black and 117 white. The annual incidence was 0.8/100,000 black @entity0 and 3.3/100,000 white. The low incidence in black @entity0 was due to the very low incidence of @entity2 ( @entity2 ), which was 0.41/100,000 black @entity0 compared with 2.73/100,000 white @entity0 . The incidence of @entity5 ( @entity5 ) was approximately the same for both ethnic groups; 0.38/100,000 black @entity0 and 0.57/100,000 white @entity0 . Remission rates for black @entity0 with @entity2 were lower than for white @entity0 and the cumulative proportion of black @entity0 surviving at 60 months was only 32% compared with 72% of white @entity0 (p = 0.0001). The most significant poor prognostic factors in @entity2 were ethnic group and age (p = 0.0006), @entity1 at onset (p = 0.006), @entity3 L2 and L3 morphology (p = 0.05), and irregular clinic attendance during maintenance therapy (p = 0.05). In @entity5 , remission and survival rates were less favorable than in @entity2 but there were no significant differences between black and white @entity0 . Black @entity0 exhibited certain clinical features rarely seen in white @entity0 , including chloromata, oropharyngeal lesions, and CNS involvement at onset. @entity6 were common. The most significant poor prognostic factors in @entity5 were @entity1 at onset (p = 0.03), generalized @entity7 (p = 0.0001), and @entity3 morphology classification M3-M6 (p = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Acute XXXX in Johannesburg. Ethnic differences in incidence, cell type, and survival.

answer: @entity4


abstract: OBJECTIVES: Comorbid major @entity2 is associated with reduced quality of life and greater use of healthcare resources. A recent randomised trial (SMaRT, Symptom Management Research Trials, Oncology-2) found that a collaborative care treatment programme ( @entity2 Care for @entity0 with @entity1 , @entity3 ) was highly effective in treating @entity2 in @entity0 with @entity1 . This study aims to estimate the cost-effectiveness of @entity3 compared with usual care from a health service perspective. METHODS: Costs were estimated using UK national unit cost estimates and health outcomes measured using quality-adjusted life-years (QALYs). Incremental cost-effectiveness of @entity3 compared with usual care was calculated and scenario analyses performed to test alternative assumptions on costs and missing data. Uncertainty was characterised using cost-effectiveness acceptability curves. The probability of @entity3 being cost-effective was determined using the UK National Institute for Health and Care Excellence's (NICE) cost-effectiveness threshold range of   20,000 to   30,000 per QALY gained. RESULTS: @entity3 cost on average   631 more than usual care per @entity0 , and resulted in a mean gain of 0.066 QALYs, yielding an incremental cost-effectiveness ratio of   9549 per QALY. The probability of @entity3 being cost-effective was 0.9 or greater at cost-effectiveness thresholds above   20,000 per QALY for the base case and scenario analyses. CONCLUSIONS: Compared with usual care, @entity3 is likely to be cost-effective at the current thresholds used by NICE. This study adds to the weight of evidence that collaborative care treatment models are cost-effective for @entity2 , and provides new evidence regarding their use in specialist medical settings.

title: Cost-effectiveness of integrated collaborative care for comorbid major XXXX in @entity0 with @entity1 .

answer: @entity2


abstract: OBJECTIVES: Comorbid major @entity2 is associated with reduced quality of life and greater use of healthcare resources. A recent randomised trial (SMaRT, Symptom Management Research Trials, Oncology-2) found that a collaborative care treatment programme ( @entity2 Care for @entity0 with @entity1 , @entity3 ) was highly effective in treating @entity2 in @entity0 with @entity1 . This study aims to estimate the cost-effectiveness of @entity3 compared with usual care from a health service perspective. METHODS: Costs were estimated using UK national unit cost estimates and health outcomes measured using quality-adjusted life-years (QALYs). Incremental cost-effectiveness of @entity3 compared with usual care was calculated and scenario analyses performed to test alternative assumptions on costs and missing data. Uncertainty was characterised using cost-effectiveness acceptability curves. The probability of @entity3 being cost-effective was determined using the UK National Institute for Health and Care Excellence's (NICE) cost-effectiveness threshold range of   20,000 to   30,000 per QALY gained. RESULTS: @entity3 cost on average   631 more than usual care per @entity0 , and resulted in a mean gain of 0.066 QALYs, yielding an incremental cost-effectiveness ratio of   9549 per QALY. The probability of @entity3 being cost-effective was 0.9 or greater at cost-effectiveness thresholds above   20,000 per QALY for the base case and scenario analyses. CONCLUSIONS: Compared with usual care, @entity3 is likely to be cost-effective at the current thresholds used by NICE. This study adds to the weight of evidence that collaborative care treatment models are cost-effective for @entity2 , and provides new evidence regarding their use in specialist medical settings.

title: Cost-effectiveness of integrated collaborative care for comorbid major @entity2 in @entity0 with XXXX .

answer: @entity1


abstract: OBJECTIVES: Comorbid major @entity2 is associated with reduced quality of life and greater use of healthcare resources. A recent randomised trial (SMaRT, Symptom Management Research Trials, Oncology-2) found that a collaborative care treatment programme ( @entity2 Care for @entity0 with @entity1 , @entity3 ) was highly effective in treating @entity2 in @entity0 with @entity1 . This study aims to estimate the cost-effectiveness of @entity3 compared with usual care from a health service perspective. METHODS: Costs were estimated using UK national unit cost estimates and health outcomes measured using quality-adjusted life-years (QALYs). Incremental cost-effectiveness of @entity3 compared with usual care was calculated and scenario analyses performed to test alternative assumptions on costs and missing data. Uncertainty was characterised using cost-effectiveness acceptability curves. The probability of @entity3 being cost-effective was determined using the UK National Institute for Health and Care Excellence's (NICE) cost-effectiveness threshold range of   20,000 to   30,000 per QALY gained. RESULTS: @entity3 cost on average   631 more than usual care per @entity0 , and resulted in a mean gain of 0.066 QALYs, yielding an incremental cost-effectiveness ratio of   9549 per QALY. The probability of @entity3 being cost-effective was 0.9 or greater at cost-effectiveness thresholds above   20,000 per QALY for the base case and scenario analyses. CONCLUSIONS: Compared with usual care, @entity3 is likely to be cost-effective at the current thresholds used by NICE. This study adds to the weight of evidence that collaborative care treatment models are cost-effective for @entity2 , and provides new evidence regarding their use in specialist medical settings.

title: Cost-effectiveness of integrated collaborative care for comorbid major @entity2 in XXXX with @entity1 .

answer: @entity0


abstract: The @entity1 pancreas, an immature organ at birth, reaches its adult size and morphology after weaning (3 weeks of age). Around this time, apoptotic phenomena and various types of macrophages are normally present. During development, @entity5 ( @entity5 ) interactions are known to play a role in apoptotic events involved in tissue remodeling and elimination of damaged cells, and macrophages are routinely observed near apoptotic cells. Apoptosis and Fas- @entity5 interactions are also thought to be involved in the pathogenesis of @entity2 , particularly @entity4 ( @entity4 ). Therefore, we used early postnatal @entity1 pancreata from three control strains (C57BL/6, DBA/2, BALB/c) and from two strains with the nonobese @entity0 (NOD)-related genetic background (the spontaneous @entity4 NOD model and the lymphocyte-deficient NODscid strain) to study apoptotic phenomena together with the molecular and immunohistochemical expression of proapoptosis (Fas, @entity5 ) and antiapoptosis ( @entity3 ) proteins. First, although no major difference in the numbers of total pancreatic apoptotic cells was noted among strains, significantly more @entity5 (+) expression was detected immunohistochemically in @entity1 with the NOD genetic background than in control pancreata from birth to 1 month of age. Second, @entity5 (+), Fas(+), and @entity3 (+) structures seemed to be associated with innervation, regardless of the strain and age. Third, in control and NOD strains, nerves (identified by immunohistochemical labeling of @entity6 or neurofilament 200), were often observed in periductular and peri-insular areas. Finally, some @entity6 -positive nerves expressed the interferon-inducible protein-10 chemokine, and various types of macrophages were found to be in close proximity. These data highlight an overlooked, innervation-related aspect of normal @entity1 postnatal pancreas development with possible implications in @entity4 pathogenesis.

title: Proapoptosis and antiapoptosis-related molecules during postnatal pancreas development in control and nonobese XXXX @entity1 : relationship with innervation.

answer: @entity0


abstract: The @entity1 pancreas, an immature organ at birth, reaches its adult size and morphology after weaning (3 weeks of age). Around this time, apoptotic phenomena and various types of macrophages are normally present. During development, @entity5 ( @entity5 ) interactions are known to play a role in apoptotic events involved in tissue remodeling and elimination of damaged cells, and macrophages are routinely observed near apoptotic cells. Apoptosis and Fas- @entity5 interactions are also thought to be involved in the pathogenesis of @entity2 , particularly @entity4 ( @entity4 ). Therefore, we used early postnatal @entity1 pancreata from three control strains (C57BL/6, DBA/2, BALB/c) and from two strains with the nonobese @entity0 (NOD)-related genetic background (the spontaneous @entity4 NOD model and the lymphocyte-deficient NODscid strain) to study apoptotic phenomena together with the molecular and immunohistochemical expression of proapoptosis (Fas, @entity5 ) and antiapoptosis ( @entity3 ) proteins. First, although no major difference in the numbers of total pancreatic apoptotic cells was noted among strains, significantly more @entity5 (+) expression was detected immunohistochemically in @entity1 with the NOD genetic background than in control pancreata from birth to 1 month of age. Second, @entity5 (+), Fas(+), and @entity3 (+) structures seemed to be associated with innervation, regardless of the strain and age. Third, in control and NOD strains, nerves (identified by immunohistochemical labeling of @entity6 or neurofilament 200), were often observed in periductular and peri-insular areas. Finally, some @entity6 -positive nerves expressed the interferon-inducible protein-10 chemokine, and various types of macrophages were found to be in close proximity. These data highlight an overlooked, innervation-related aspect of normal @entity1 postnatal pancreas development with possible implications in @entity4 pathogenesis.

title: Proapoptosis and antiapoptosis-related molecules during postnatal pancreas development in control and nonobese @entity0 XXXX : relationship with innervation.

answer: @entity1


abstract: AIM: Antenatal detection of right-sided stomach (dextrogastria) is rare, and its significance in regards to @entity5 is unclear. We aimed to review all cases of antenatally-diagnosed dextrogastria in our regional fetal medicine unit over 10years. METHODS: A retrospective case-note review of @entity0 identified from a prospectively-maintained database was performed. RESULTS: Twenty cases of antenatally-diagnosed dextrogastria were identified from 2004 to 2014. There were 8 terminations and 1 @entity1 . One @entity0 has no post-natal information obtainable. Ten @entity0 were live-born, and 2 died secondary to @entity2 in the neonatal period. All had significant @entity2 on postnatal assessment, including the 3 neonates in whom dextrogastria was the only antenatal finding. Two neonates developed @entity4 and underwent Ladd's procedure. Operative findings were dextrogastria/ @entity7 in both. A third @entity0 had @entity3 , and contrast demonstrated stable duodenal/midgut position. This @entity0 has not developed symptoms attributable to @entity7 and not undergone surgery. All 3 of these @entity0 had @entity8 or @entity8 and were managed with antibiotic prophylaxis/immunisation. Five @entity0 in the series were not investigated for @entity7 and have not come to surgical attention (one is known to be asplenic). CONCLUSION: Antenatally-detected dextrogastria, even if apparently isolated, was always associated with postnatal significant @entity6 , @entity9 or situs inversus. This may be important for antenatal counselling. We currently recommend postnatal echocardiography and splenic assessment, but reserve GI investigation/intervention for symptomatic @entity7 owing to potential significant cardiac comorbidity.

title: Antenatally diagnosed right-sided stomach (dextrogastria): A XXXX .

answer: @entity5


abstract: Our objectives were to document CT features of advanced primary @entity1 (LELC) and to determine features that may assist differentiation from other @entity5 ( @entity5 ). Imaging and clinical data of all @entity0 with biopsy-proven @entity1 ( n=12) were retrieved from a database of all @entity5 @entity0 over a 2-year period. Twenty-five controls were recruited from other inoperable non-LELC @entity5 @entity0 from the database. Pre-treatment CT scans of the thorax of both study and control @entity0 were reviewed for lobe involved; @entity3 site, borders and size; and pleural, vascular or @entity4 . Presence of @entity6 was noted. Lymph node @entity2 was characterised as ipsilateral or contralateral enlarged (>1 cm) mediastinal or hilar nodes, or as peribronchovascular nodal spread. Differences between the two groups were tested using Mann-Whitney rank-sum test. The @entity3 were significantly larger (45.67 vs 17.71 cm(2)) than controls and were closely associated with the mediastinum. There were more @entity3 with well-defined borders ( p<0.001) and fewer with spiculated borders ( p<0001) than @entity3 . There was increased peribronchovascular nodal spread ( p=0.01) and vascular encasement ( p=0.02) in LELC compared with @entity3 . Advanced primary @entity1 has distinct radiological features, and can appear as well-defined @entity3 closely associated with the mediastinum, with peribronchovascular spread and vascular encasement.

title: Computed tomography characteristics of advanced primary XXXX .

answer: @entity1


abstract: Aim of the study was to analyse the results following osteosynthesis of proximal humerus @entity2 with cannulated blade plate 90 degrees (Synthes, Mathys Medizinaltechnik AG, Bettlach, Schweiz) in elderly @entity0 . Between 6/1998 and 12/1999 we treated 20 @entity0 (12 female, 8 male) > 65 years (65-92 y, 75 y) with the cannulated blade plate ( @entity2 type according to AO: 8 x 11-A3, 5 x 11-B1, 3 x 11-B2, 1 x 11-B3 und 3 x 11-C2). Regarding to mechanical and functional advantages we modified the 90 degrees angulation of the implant by bending intraoperatively up to 110-120 degrees. Early post-op physiotherapy was permitted. The radiological results of all @entity0 were evaluated and in 13 @entity0 a clinical follow-up (median 8 months) was obtained. According to the Constant-score 62 points on average were achieved, which corresponds to a satisfactory result (contralateral shoulder 92 points). Complications due to the implant were loosening of the blade plate in 3 cases (A3, B2, C2) and 1 perforation of the blade plate (C2). The consecutive reoperation consisted in a compound osteosynthesis with the blade plate (A3, B2) in 2 cases, a prosthetic replacement and a removal of the implant (C2) in 1 case respectively. Neither @entity3 nor avascular @entity1 occurred. The cannulated blade plate 90 degrees represents a justified alternative in the treatment of displaced @entity2 of the proximal humerus in elderly @entity0 . Commendable indications are @entity2 types A and B according to AO with stable fixation of the blade plate in the humeral head, which allow early physiotherapy and avoid an alteration of the rotator cuff. @entity2 tend to complications (2/3).

title: [The cannulated blade plate 90 degrees for displaced proximal humeral fractures in elderly XXXX ].

answer: @entity0


abstract: BACKGROUND/OBJECTIVES: @entity0 with @entity4 are exposed by repeated imaging to ionizing radiation, which may have important implications for lifetime health risks. Leukocyte telomere length (LTL), a reliable biomarker of genomic instability, is associated with increased risk of @entity1 and @entity2 . We investigated LTL in grown-up @entity0 with CHD (GUCHs) and a positive history of medical radiation exposure as well as the influence of functional polymorphisms of genes involved in DNA repair. METHODS: A group of 50 GUCH @entity0 (26 males; age 25.2  9.0years) and 50 healthy age/gender-matched subjects (20 males; 27.0  3.1years) were enrolled. In GUCH @entity0 , the cumulative exposure was estimated as effective dose (ED) in milliSievert. LTL was measured by quantitative RT-PCR. @entity5 ( @entity5 ) and @entity7 ( @entity7 ) SNPs (XRCC1 @entity6 , XRCC1Arg194Tr and @entity7 @entity8 ) were evaluated. RESULTS: GUCHs showed significantly shorter LTL compared with controls (1.0  0.3 vs 1.3  0.4, p=0.001). A significant inverse correlation between LTL and cumulative radiological ED was observed (r=-0.34, p=0.03). @entity0 with Thr/Met @entity7 or Met/Met @entity7 genotypes were significantly associated with a significantly shorter LTL compared with wild-type genotype (p=0.01 for Thr/Met and p=0.008 for Met/Met). Carriers of @entity5 194Trp and @entity7 241Met alleles presented a significant interaction with cumulative radiation dose exposure for LTL (both pinteraction=0.02). CONCLUSIONS: GUCH @entity0 have LTL shortening, suggesting evidence of early biological aging. Common SNPs in DNA repair genes modify the effects of medical exposure to radiation LTL-related @entity3 .

title: Leukocyte telomere shortening in grown-up @entity0 with XXXX .

answer: @entity4


abstract: BACKGROUND/OBJECTIVES: @entity0 with @entity4 are exposed by repeated imaging to ionizing radiation, which may have important implications for lifetime health risks. Leukocyte telomere length (LTL), a reliable biomarker of genomic instability, is associated with increased risk of @entity1 and @entity2 . We investigated LTL in grown-up @entity0 with CHD (GUCHs) and a positive history of medical radiation exposure as well as the influence of functional polymorphisms of genes involved in DNA repair. METHODS: A group of 50 GUCH @entity0 (26 males; age 25.2  9.0years) and 50 healthy age/gender-matched subjects (20 males; 27.0  3.1years) were enrolled. In GUCH @entity0 , the cumulative exposure was estimated as effective dose (ED) in milliSievert. LTL was measured by quantitative RT-PCR. @entity5 ( @entity5 ) and @entity7 ( @entity7 ) SNPs (XRCC1 @entity6 , XRCC1Arg194Tr and @entity7 @entity8 ) were evaluated. RESULTS: GUCHs showed significantly shorter LTL compared with controls (1.0  0.3 vs 1.3  0.4, p=0.001). A significant inverse correlation between LTL and cumulative radiological ED was observed (r=-0.34, p=0.03). @entity0 with Thr/Met @entity7 or Met/Met @entity7 genotypes were significantly associated with a significantly shorter LTL compared with wild-type genotype (p=0.01 for Thr/Met and p=0.008 for Met/Met). Carriers of @entity5 194Trp and @entity7 241Met alleles presented a significant interaction with cumulative radiation dose exposure for LTL (both pinteraction=0.02). CONCLUSIONS: GUCH @entity0 have LTL shortening, suggesting evidence of early biological aging. Common SNPs in DNA repair genes modify the effects of medical exposure to radiation LTL-related @entity3 .

title: Leukocyte telomere shortening in grown-up XXXX with @entity4 .

answer: @entity0


abstract: UNASSIGNED: @entity4 nanoparticles (HAP NPs) are widely used for preparations of biomedical and biotechnological fields such as drug delivery, gene therapy, and molecular imaging. However, the current toxicological knowledge about HAP NPs is relatively limited. The present study was designed to investigate the @entity3 potentials of various concentrations (0-1000   g cm(-2)) of HAP NPs in cultured primary @entity0 hepatocytes. Cell viability was detected by @entity6 ( @entity2 ) assay and @entity5 dehydrogenase (LDH) release, while total antioxidant capacity (TAC) and @entity1 ( @entity1 ) levels were determined to evaluate the oxidative injury. The DNA damage was also analyzed via scoring liver micronuclei rates and determining @entity7 ( @entity7 ) levels. The results of @entity2 and LDH assays showed that the higher concentrations of dispersed HAP NPs (300, 500, and 1000   g cm(-2)) decreased cell viability. Also, HAP NPs increased @entity1 (500 and 1000   g cm(-2)) levels and decreased TAC (300, 500, and 1000   g cm(-2)) levels in cultured hepatocytes. On the basis of increasing doses, the NPs as depending on dose caused significant increases of the number of micronucleated hepatocytes and @entity7 levels as compared to control culture. Furthermore, the highest concentration of HAP NPs (1000   g cm(-2)) exhibited cytotoxic activity. Based on these results, HAP NPs have a dose-dependent toxic effect in @entity0 hepatocytes. Further extensive research in this field is promising and reasonable.

title: XXXX assessment of @entity4 nanoparticles in @entity0 liver cell model in vitro.

answer: @entity3


abstract: UNASSIGNED: @entity4 nanoparticles (HAP NPs) are widely used for preparations of biomedical and biotechnological fields such as drug delivery, gene therapy, and molecular imaging. However, the current toxicological knowledge about HAP NPs is relatively limited. The present study was designed to investigate the @entity3 potentials of various concentrations (0-1000   g cm(-2)) of HAP NPs in cultured primary @entity0 hepatocytes. Cell viability was detected by @entity6 ( @entity2 ) assay and @entity5 dehydrogenase (LDH) release, while total antioxidant capacity (TAC) and @entity1 ( @entity1 ) levels were determined to evaluate the oxidative injury. The DNA damage was also analyzed via scoring liver micronuclei rates and determining @entity7 ( @entity7 ) levels. The results of @entity2 and LDH assays showed that the higher concentrations of dispersed HAP NPs (300, 500, and 1000   g cm(-2)) decreased cell viability. Also, HAP NPs increased @entity1 (500 and 1000   g cm(-2)) levels and decreased TAC (300, 500, and 1000   g cm(-2)) levels in cultured hepatocytes. On the basis of increasing doses, the NPs as depending on dose caused significant increases of the number of micronucleated hepatocytes and @entity7 levels as compared to control culture. Furthermore, the highest concentration of HAP NPs (1000   g cm(-2)) exhibited cytotoxic activity. Based on these results, HAP NPs have a dose-dependent toxic effect in @entity0 hepatocytes. Further extensive research in this field is promising and reasonable.

title: @entity3 assessment of XXXX nanoparticles in @entity0 liver cell model in vitro.

answer: @entity4


abstract: UNASSIGNED: @entity4 nanoparticles (HAP NPs) are widely used for preparations of biomedical and biotechnological fields such as drug delivery, gene therapy, and molecular imaging. However, the current toxicological knowledge about HAP NPs is relatively limited. The present study was designed to investigate the @entity3 potentials of various concentrations (0-1000   g cm(-2)) of HAP NPs in cultured primary @entity0 hepatocytes. Cell viability was detected by @entity6 ( @entity2 ) assay and @entity5 dehydrogenase (LDH) release, while total antioxidant capacity (TAC) and @entity1 ( @entity1 ) levels were determined to evaluate the oxidative injury. The DNA damage was also analyzed via scoring liver micronuclei rates and determining @entity7 ( @entity7 ) levels. The results of @entity2 and LDH assays showed that the higher concentrations of dispersed HAP NPs (300, 500, and 1000   g cm(-2)) decreased cell viability. Also, HAP NPs increased @entity1 (500 and 1000   g cm(-2)) levels and decreased TAC (300, 500, and 1000   g cm(-2)) levels in cultured hepatocytes. On the basis of increasing doses, the NPs as depending on dose caused significant increases of the number of micronucleated hepatocytes and @entity7 levels as compared to control culture. Furthermore, the highest concentration of HAP NPs (1000   g cm(-2)) exhibited cytotoxic activity. Based on these results, HAP NPs have a dose-dependent toxic effect in @entity0 hepatocytes. Further extensive research in this field is promising and reasonable.

title: @entity3 assessment of @entity4 nanoparticles in XXXX liver cell model in vitro.

answer: @entity0


abstract: BACKGROUND: @entity4 ( @entity4 ) are often found among @entity0 exposed to @entity3 ( @entity3 ). The role of @entity6 ( @entity6 ) as a protective factor against @entity5 among @entity3 -exposed @entity0 is not firmly established. OBJECTIVE: The objective of this study is to determine the distribution of risk of @entity4 among @entity0 exposed to @entity3 and to examine the impact of @entity6 on risk of @entity5 among @entity3 -exposed @entity0 . METHODS: @entity0 (aged 18-64 years) exposed to @entity3 during their lifetimes (defined by the Humiliation-Afraid-Rape-Kick instrument) were recruited from primary care and domestic violence service agencies and surveyed on demographics, mood/ @entity1 , psychosocial/community factors, and strategies used in response to @entity3 . The Eating Disorder Screen for Primary Care assessed the risk of @entity5 . A modified Medical Outcomes Study Social Support Survey assessed overall functional support (scale range: 0-32; categorized into quartiles). Ordinal logistic regression examined the risk of @entity5 based on @entity6 , controlling for prespecified demographics (age, race/ethnicity, marital status, near-poverty level), and health-related factors significant in bivariate analyses (risky @entity2 use). RESULTS: Among 302 @entity0 with lifetime @entity3 , 41 (14%) were at high risk, 127 (42%) were at moderate risk, and 134 (44%) were at low risk of an @entity5 . In bivariate analyses, high risk of an @entity5 was significantly more frequent among @entity0 with a low @entity6 score (<19, 24%) versus a high @entity6 score (>= 30, 12%) (P=0.03). High risk of an @entity5 was significantly associated with risky @entity2 use (18%) versus non-risky @entity2 use (13%; P=0.008). In multivariable analysis, a 5-unit increase in overall @entity6 was significantly associated with decreased odds of @entity5 risk (P=0.007). CONCLUSION: Among @entity3 -exposed @entity0 , low @entity6 is associated with an increased risk of @entity5 . @entity6 may protect against @entity5 by reducing @entity1 and promoting positive actions, but further study is needed to confirm this.

title: The impact of XXXX on the risk of @entity4 in @entity0 exposed to @entity3 .

answer: @entity6


abstract: BACKGROUND: @entity4 ( @entity4 ) are often found among @entity0 exposed to @entity3 ( @entity3 ). The role of @entity6 ( @entity6 ) as a protective factor against @entity5 among @entity3 -exposed @entity0 is not firmly established. OBJECTIVE: The objective of this study is to determine the distribution of risk of @entity4 among @entity0 exposed to @entity3 and to examine the impact of @entity6 on risk of @entity5 among @entity3 -exposed @entity0 . METHODS: @entity0 (aged 18-64 years) exposed to @entity3 during their lifetimes (defined by the Humiliation-Afraid-Rape-Kick instrument) were recruited from primary care and domestic violence service agencies and surveyed on demographics, mood/ @entity1 , psychosocial/community factors, and strategies used in response to @entity3 . The Eating Disorder Screen for Primary Care assessed the risk of @entity5 . A modified Medical Outcomes Study Social Support Survey assessed overall functional support (scale range: 0-32; categorized into quartiles). Ordinal logistic regression examined the risk of @entity5 based on @entity6 , controlling for prespecified demographics (age, race/ethnicity, marital status, near-poverty level), and health-related factors significant in bivariate analyses (risky @entity2 use). RESULTS: Among 302 @entity0 with lifetime @entity3 , 41 (14%) were at high risk, 127 (42%) were at moderate risk, and 134 (44%) were at low risk of an @entity5 . In bivariate analyses, high risk of an @entity5 was significantly more frequent among @entity0 with a low @entity6 score (<19, 24%) versus a high @entity6 score (>= 30, 12%) (P=0.03). High risk of an @entity5 was significantly associated with risky @entity2 use (18%) versus non-risky @entity2 use (13%; P=0.008). In multivariable analysis, a 5-unit increase in overall @entity6 was significantly associated with decreased odds of @entity5 risk (P=0.007). CONCLUSION: Among @entity3 -exposed @entity0 , low @entity6 is associated with an increased risk of @entity5 . @entity6 may protect against @entity5 by reducing @entity1 and promoting positive actions, but further study is needed to confirm this.

title: The impact of @entity6 on the risk of XXXX in @entity0 exposed to @entity3 .

answer: @entity4


abstract: BACKGROUND: @entity4 ( @entity4 ) are often found among @entity0 exposed to @entity3 ( @entity3 ). The role of @entity6 ( @entity6 ) as a protective factor against @entity5 among @entity3 -exposed @entity0 is not firmly established. OBJECTIVE: The objective of this study is to determine the distribution of risk of @entity4 among @entity0 exposed to @entity3 and to examine the impact of @entity6 on risk of @entity5 among @entity3 -exposed @entity0 . METHODS: @entity0 (aged 18-64 years) exposed to @entity3 during their lifetimes (defined by the Humiliation-Afraid-Rape-Kick instrument) were recruited from primary care and domestic violence service agencies and surveyed on demographics, mood/ @entity1 , psychosocial/community factors, and strategies used in response to @entity3 . The Eating Disorder Screen for Primary Care assessed the risk of @entity5 . A modified Medical Outcomes Study Social Support Survey assessed overall functional support (scale range: 0-32; categorized into quartiles). Ordinal logistic regression examined the risk of @entity5 based on @entity6 , controlling for prespecified demographics (age, race/ethnicity, marital status, near-poverty level), and health-related factors significant in bivariate analyses (risky @entity2 use). RESULTS: Among 302 @entity0 with lifetime @entity3 , 41 (14%) were at high risk, 127 (42%) were at moderate risk, and 134 (44%) were at low risk of an @entity5 . In bivariate analyses, high risk of an @entity5 was significantly more frequent among @entity0 with a low @entity6 score (<19, 24%) versus a high @entity6 score (>= 30, 12%) (P=0.03). High risk of an @entity5 was significantly associated with risky @entity2 use (18%) versus non-risky @entity2 use (13%; P=0.008). In multivariable analysis, a 5-unit increase in overall @entity6 was significantly associated with decreased odds of @entity5 risk (P=0.007). CONCLUSION: Among @entity3 -exposed @entity0 , low @entity6 is associated with an increased risk of @entity5 . @entity6 may protect against @entity5 by reducing @entity1 and promoting positive actions, but further study is needed to confirm this.

title: The impact of @entity6 on the risk of @entity4 in @entity0 exposed to XXXX .

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) are often found among @entity0 exposed to @entity3 ( @entity3 ). The role of @entity6 ( @entity6 ) as a protective factor against @entity5 among @entity3 -exposed @entity0 is not firmly established. OBJECTIVE: The objective of this study is to determine the distribution of risk of @entity4 among @entity0 exposed to @entity3 and to examine the impact of @entity6 on risk of @entity5 among @entity3 -exposed @entity0 . METHODS: @entity0 (aged 18-64 years) exposed to @entity3 during their lifetimes (defined by the Humiliation-Afraid-Rape-Kick instrument) were recruited from primary care and domestic violence service agencies and surveyed on demographics, mood/ @entity1 , psychosocial/community factors, and strategies used in response to @entity3 . The Eating Disorder Screen for Primary Care assessed the risk of @entity5 . A modified Medical Outcomes Study Social Support Survey assessed overall functional support (scale range: 0-32; categorized into quartiles). Ordinal logistic regression examined the risk of @entity5 based on @entity6 , controlling for prespecified demographics (age, race/ethnicity, marital status, near-poverty level), and health-related factors significant in bivariate analyses (risky @entity2 use). RESULTS: Among 302 @entity0 with lifetime @entity3 , 41 (14%) were at high risk, 127 (42%) were at moderate risk, and 134 (44%) were at low risk of an @entity5 . In bivariate analyses, high risk of an @entity5 was significantly more frequent among @entity0 with a low @entity6 score (<19, 24%) versus a high @entity6 score (>= 30, 12%) (P=0.03). High risk of an @entity5 was significantly associated with risky @entity2 use (18%) versus non-risky @entity2 use (13%; P=0.008). In multivariable analysis, a 5-unit increase in overall @entity6 was significantly associated with decreased odds of @entity5 risk (P=0.007). CONCLUSION: Among @entity3 -exposed @entity0 , low @entity6 is associated with an increased risk of @entity5 . @entity6 may protect against @entity5 by reducing @entity1 and promoting positive actions, but further study is needed to confirm this.

title: The impact of @entity6 on the risk of @entity4 in XXXX exposed to @entity3 .

answer: @entity0


abstract: OBJECTIVE: To compare the open Lichtenstein repair and laparoscopic mesh repair for direct @entity2 in terms of immediate post operative @entity1 and length of hospital stay. METHODS: This randomized control trial was conducted at Benazir Bhutto Hospital Rawalpindi from January 2009 to June 2010. All @entity0 presenting in the surgical OPD with @entity2 , ASA I/II, were randomly divided in two equal groups. Group-I, @entity0 underwent Lichtenstein's repair and Group-II had hernioplasty by laparoscopic method (TAPP). Post operative @entity1 intensity assessed by VAS and hospital stay measured in hours. RESULTS: A total 60 @entity0 of @entity2 were studied. The mean age was 61.48  7. The range of postoperative @entity1 experienced was 5.55 as per VAS among all @entity0 . In group-I (open hernioplasty) majority of @entity0 (53.33%, n=16) experience severe type of @entity1 where as in group-II, moderate severity of @entity1 was reported by large number of @entity0 (63.34%, n=19). The mean post operative @entity1 intensity as per VAS was 6.23 in group-I and 4.43 in group-II @entity0 . The mean length of hospital stay was slightly less (35.10 hrs) in group-I as compared to group-II (38.70 hrs). CONCLUSION: There is definitely less post operative @entity1 after laparoscopic repair but hospital stay is same in both the procedures but laparoscopic procedure does increase the cost.

title: A comparison of post operative @entity1 and hospital stay between Lichtenstein's repair and Laparoscopic Transabdominal Preperitoneal (TAPP) repair of XXXX : A randomized controlled trial.

answer: @entity2