abstract: STUDY DESIGN: Case report. BACKGROUND: Cross-sectional studies have examined deficits following anterior cruciate ligament (ACL) @entity1 and subsequent reconstructive surgery. Few studies present preinjury data that may assist in identifying risk factors for @entity4 . This case report compares gait and strength measures obtained prior to @entity4 , with follow-up assessments of these measures after @entity1 and reconstructive surgery. CASE DESCRIPTION: A 23-year-old @entity0 sustained a noncontact @entity1 of her right ACL. Kinematic and kinetic gait data were collected using 3-dimensional motion analysis and a synchronized force plate. Knee strength was measured using an isokinetic dynamometer. Data for knee active range of motion (AROM) and the Lower Extremity Functional Scale (LEFS) were also collected. The analyses were descriptive and interpreted based on previously published minimal detectable change and minimal clinically important difference values. OUTCOMES: Before her injury, the @entity0 demonstrated a low external knee flexion moment during gait. Kinematic and @entity2 were present following @entity1 and persisted at 13 months postsurgery. The @entity0 demonstrated knee strength deficits following @entity4 and surgery. @entity3 in LEFS and knee AROM occurred following @entity1 and surgery. DISCUSSION: Preinjury data may identify risk factors for @entity4 . Future studies should examine whether a low external knee flexion moment during gait or sport-related activity is a risk factor for @entity4 . The @entity0 demonstrated deficits in gait and strength that persisted at 13 months postsurgery. LEVEL OF EVIDENCE: Therapy, level 4.

title: Longitudinal gait and strength changes prior to and following an anterior cruciate XXXX and surgical reconstruction: a case report.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Prospective data are lacking to determine which @entity0 might benefit from prompt neuroimaging after unprovoked @entity2 . We aimed to determine the prevalence of, and risk factors for, relevant @entity4 in @entity0 with first, unprovoked @entity2 . METHODS: We conducted a 6-center prospective study in @entity0 aged >28 days to 18 years with seemingly unprovoked @entity2 . @entity1 ( @entity1 ) clinicians documented clinical findings on a standardized form. Our main outcome was the presence of a clinically relevant intracranial abnormality on computed tomography (CT) or MRI, defined as those that might change management, either emergently, urgently, or nonurgently. RESULTS: We enrolled 475 of 625 (76%) eligible @entity0 . Of 354 @entity0 for whom cranial MRI or CT scans were obtained in the @entity1 or within 4 months of the @entity1 visit, 40 (11.3%; 95% confidence interval [CI]: 8.0-14.6%) had clinically relevant @entity4 , with 3 (0.8%; 95% CI: 0.1-1.8%) having emergent/urgent abnormalities. On logistic regression analysis, a high-risk past medical history (adjusted odds ratio: 9.2; 95% CI: 2.4-35.7) and any focal aspect to the @entity2 (odds ratio: 2.5; 95% CI: 1.2-5.3) were independently associated with clinically @entity3 . CONCLUSIONS: Clinically relevant @entity4 occur in 11% of @entity0 with first, unprovoked @entity2 . Emergent/urgent abnormalities, however, occur in <1%, suggesting that most @entity0 do not require neuroimaging in the @entity1 . Findings on @entity0 history and physical examination identify @entity0 at higher risk of @entity3 .

title: Prevalence of and Risk Factors for Intracranial XXXX .

answer: @entity2


abstract: BACKGROUND: The independent prognostic significance of @entity2 ( @entity2 ) of blood pressure (BP) is not yet clear. We investigated the association between @entity2 of systolic BP and risk of coronary events in elderly treated @entity1 @entity0 . METHODS: The occurrence of coronary events was evaluated in 1,191 elderly treated @entity1 @entity0 (age range 60-90 years). Subjects were divided according to tertiles of @entity2 of systolic BP of the population as a whole, by dipping status and by group-specific tertiles of @entity2 of systolic BP in dippers and nondippers. RESULTS: During the follow-up (9.1    4.9 years, range 0.4-20 years), 120 coronary events occurred. In the population as a whole, coronary event risk was not significantly associated with tertiles of @entity2 of systolic BP, whereas nondippers were at higher risk than dippers. When nondippers and dippers were analyzed separately, by group-specific tertiles of @entity2 of systolic BP, coronary event risk was associated with @entity2 of systolic BP in dippers but not in nondippers. After adjustment for various covariates, Cox regression analysis showed that dippers in the third tertile (>23 mm Hg) of @entity2 of systolic BP (hazard ratio 1.912, 95% confidence interval 1.048-3.488, P = 0.03) and nondippers (hazard ratio 1.739, 95% confidence interval 1.074-2.815, P = 0.02) were at higher coronary event risk than dippers with @entity2 of systolic BP <23 mm Hg . CONCLUSIONS: In elderly treated @entity1 @entity0 , high @entity2 of systolic BP predicts coronary events in dippers but not in nondippers. Nondippers, however, show higher risk of coronary events independently of @entity2 in systolic BP.

title: Morning Blood Pressure Surge, Dipping, and Risk of Coronary Events in Elderly Treated XXXX @entity0 .

answer: @entity1


abstract: BACKGROUND: The independent prognostic significance of @entity2 ( @entity2 ) of blood pressure (BP) is not yet clear. We investigated the association between @entity2 of systolic BP and risk of coronary events in elderly treated @entity1 @entity0 . METHODS: The occurrence of coronary events was evaluated in 1,191 elderly treated @entity1 @entity0 (age range 60-90 years). Subjects were divided according to tertiles of @entity2 of systolic BP of the population as a whole, by dipping status and by group-specific tertiles of @entity2 of systolic BP in dippers and nondippers. RESULTS: During the follow-up (9.1    4.9 years, range 0.4-20 years), 120 coronary events occurred. In the population as a whole, coronary event risk was not significantly associated with tertiles of @entity2 of systolic BP, whereas nondippers were at higher risk than dippers. When nondippers and dippers were analyzed separately, by group-specific tertiles of @entity2 of systolic BP, coronary event risk was associated with @entity2 of systolic BP in dippers but not in nondippers. After adjustment for various covariates, Cox regression analysis showed that dippers in the third tertile (>23 mm Hg) of @entity2 of systolic BP (hazard ratio 1.912, 95% confidence interval 1.048-3.488, P = 0.03) and nondippers (hazard ratio 1.739, 95% confidence interval 1.074-2.815, P = 0.02) were at higher coronary event risk than dippers with @entity2 of systolic BP <23 mm Hg . CONCLUSIONS: In elderly treated @entity1 @entity0 , high @entity2 of systolic BP predicts coronary events in dippers but not in nondippers. Nondippers, however, show higher risk of coronary events independently of @entity2 in systolic BP.

title: Morning Blood Pressure Surge, Dipping, and Risk of Coronary Events in Elderly Treated @entity1 XXXX .

answer: @entity0


abstract: BACKGROUND: Arterial stiffness is a risk factor for symptomatic @entity1 , and is associated with symptomatic @entity5 and @entity3 . Hence, we hypothesized that @entity6 would be a significant determinant of @entity4 . METHODS: The subjects were 363 individuals without symptomatic @entity4 who had their @entity6 assessed by brachial-ankle pulse wave velocity (baPWV) measurement. The subjects were classified into two groups by the presence or absence of @entity7 , as well as into three groups by grade of @entity0 ( @entity0 ). baPWV was compared among these groups. RESULTS: Eighty-six subjects had @entity7 . Of 138 subjects with WMHs, 102 were classified as having grade 1 and 36 as having grade 2 or 3 WMHs. baPWV was significantly higher in subjects with @entity7 than in those without (17.3    0.3 vs. 16.4    0.2 m/s). baPWV tended to increase with higher @entity0 grade (16.2    0.2, 16.9    0.3, and 17.8    0.5 m/s in grade 0, 1, and 2 or 3, respectively) after adjustments for confounding factors. The adjusted odds ratio (OR) for @entity7 in subjects with middle-tertile baPWV was significantly higher (OR, 2.37; 95% confidence interval, CI, 1.10-5.11) and the OR in subjects with the highest-tertile baPWV tended to be higher (OR 2.26; 95% CI 0.99-5.45) compared with the lowest-tertile baPWV. The adjusted OR for @entity0 tended to increase with increased baPWV. CONCLUSIONS: Arterial stiffness appeared to be associated with the presence of a @entity7 and @entity0 , independently of the risks for other @entity2 .

title: Association of XXXX with @entity4 : the Ohasama study.

answer: @entity6


abstract: BACKGROUND: Arterial stiffness is a risk factor for symptomatic @entity1 , and is associated with symptomatic @entity5 and @entity3 . Hence, we hypothesized that @entity6 would be a significant determinant of @entity4 . METHODS: The subjects were 363 individuals without symptomatic @entity4 who had their @entity6 assessed by brachial-ankle pulse wave velocity (baPWV) measurement. The subjects were classified into two groups by the presence or absence of @entity7 , as well as into three groups by grade of @entity0 ( @entity0 ). baPWV was compared among these groups. RESULTS: Eighty-six subjects had @entity7 . Of 138 subjects with WMHs, 102 were classified as having grade 1 and 36 as having grade 2 or 3 WMHs. baPWV was significantly higher in subjects with @entity7 than in those without (17.3    0.3 vs. 16.4    0.2 m/s). baPWV tended to increase with higher @entity0 grade (16.2    0.2, 16.9    0.3, and 17.8    0.5 m/s in grade 0, 1, and 2 or 3, respectively) after adjustments for confounding factors. The adjusted odds ratio (OR) for @entity7 in subjects with middle-tertile baPWV was significantly higher (OR, 2.37; 95% confidence interval, CI, 1.10-5.11) and the OR in subjects with the highest-tertile baPWV tended to be higher (OR 2.26; 95% CI 0.99-5.45) compared with the lowest-tertile baPWV. The adjusted OR for @entity0 tended to increase with increased baPWV. CONCLUSIONS: Arterial stiffness appeared to be associated with the presence of a @entity7 and @entity0 , independently of the risks for other @entity2 .

title: Association of @entity6 with XXXX : the Ohasama study.

answer: @entity4


abstract: @entity2 induces hypoandrogenism in adult male @entity0 . In order to assess whether this effect of CsA may be due to a direct inhibitory effect on Leydig cell function, CsA (0, 50, 500, and 5000 ng/ml) was added to a collagenase-dispersed mixed Leydig cell preparation and incubated with and without @entity4 (0, 0.1, 0.3, 1.0, 3.0, and 10.0 ng/ml). @entity3 (T) production, mitochondrial @entity1 side chain cleavage (CSCC) and microsomal 17,20-desmolase enzyme activities in Leydig cells were determined after 3 hr of incubation. In the absence of CsA, stimulation of T production was maximal (about 16-fold) with 1.0 ng/ml @entity4 . With 50 and 500 ng/ml CsA there were no changes in either the @entity4 -stimulated T levels or the two enzymatic activities. However, 5000 ng/ml CsA significantly (P less than 0.05) reduced the @entity4 (1 ng/ml)-stimulated T levels, CSCC and 17,20-desmolase activities. The high dosage of CsA (5000 ng/ml) also caused a significant decrease in cell viability (P less than 0.05) during the incubation period. These effects of CsA were not due to cremophor EL, the CsA vehicle. This in vitro data indicate that high dosages of CsA (greater than or equal to 5000 ng/ml) appear to have a cytotoxic effect on @entity0 Leydig cells that results in a decrease in T production. However, lower doses of CsA (less than 500 ng/ml) do not have any direct inhibitory effect on the @entity0 Leydig cells, suggesting that the hypoandrogenic effect of in vivo CsA in @entity0 is not due to any direct effect on the testis.

title: Effect of XXXX on steroidogenesis in @entity0 Leydig cells.

answer: @entity2


abstract: @entity2 induces hypoandrogenism in adult male @entity0 . In order to assess whether this effect of CsA may be due to a direct inhibitory effect on Leydig cell function, CsA (0, 50, 500, and 5000 ng/ml) was added to a collagenase-dispersed mixed Leydig cell preparation and incubated with and without @entity4 (0, 0.1, 0.3, 1.0, 3.0, and 10.0 ng/ml). @entity3 (T) production, mitochondrial @entity1 side chain cleavage (CSCC) and microsomal 17,20-desmolase enzyme activities in Leydig cells were determined after 3 hr of incubation. In the absence of CsA, stimulation of T production was maximal (about 16-fold) with 1.0 ng/ml @entity4 . With 50 and 500 ng/ml CsA there were no changes in either the @entity4 -stimulated T levels or the two enzymatic activities. However, 5000 ng/ml CsA significantly (P less than 0.05) reduced the @entity4 (1 ng/ml)-stimulated T levels, CSCC and 17,20-desmolase activities. The high dosage of CsA (5000 ng/ml) also caused a significant decrease in cell viability (P less than 0.05) during the incubation period. These effects of CsA were not due to cremophor EL, the CsA vehicle. This in vitro data indicate that high dosages of CsA (greater than or equal to 5000 ng/ml) appear to have a cytotoxic effect on @entity0 Leydig cells that results in a decrease in T production. However, lower doses of CsA (less than 500 ng/ml) do not have any direct inhibitory effect on the @entity0 Leydig cells, suggesting that the hypoandrogenic effect of in vivo CsA in @entity0 is not due to any direct effect on the testis.

title: Effect of @entity2 on steroidogenesis in XXXX Leydig cells.

answer: @entity0


abstract: Androgens regulate blood pressure and renal alpha 2-adrenergic receptors in a parallel fashion in the spontaneously @entity1 @entity0 (SHR). The present studies investigated whether this regulation of renal alpha 2B-adrenergic receptors occurs at the mRNA level. Male and female SHR were gonadectomized at 4 weeks of age. The gonadectomized @entity0 were implanted with or without @entity4 . Sham-gonadectomized @entity0 served as controls. Total kidney RNA was purified, and alpha 2B-adrenergic receptor mRNA was quantified with a reverse transcriptase-polymerase chain reaction (RT-PCR) assay. The assay uses a mimic RNA added at known concentrations to the sample RNA. The mimic was constructed from the target sequence in the alpha 2B-adrenergic receptor mRNA plus a 20-bp insertion of a random @entity3 sequence. The amount of alpha 2B-adrenergic receptor mRNA present in each sample was obtained by determining the equivalence point between the amount of RT-PCR product formed in the target band versus the mimic band, which were resolved by gel electrophoresis. Intact males had more than two times as much alpha 2B-adrenergic receptor mRNA as intact females. Castration of males reduced the male-female difference by more than 60%. Ovariectomy slightly increased the alpha 2B-adrenergic receptor mRNA level compared with that of intact females. Treatment with @entity2 elevated alpha 2B-adrenergic receptor mRNA levels of gonadectomized males and females to the level of intact males. The alpha 2B-adrenergic receptor mRNA levels correlated remarkably well with renal alpha 2-adrenergic receptor density. We conclude that @entity2 regulates renal alpha 2B-adrenergic receptor gene expression at the mRNA level in the SHR.

title: XXXX regulation of renal alpha 2B-adrenergic receptor mRNA levels.

answer: @entity2


abstract: OBJECTIVE: Vertebrobasilar dissecting @entity4 (VBDA) management is challenging despite the availability of multiple treatment strategies. We reviewed our experiences using endovascular treatment for VBDA @entity0 to assess the efficacy and safety of several VBDA treatment strategies. METHODS: Assisted by intra-arterial digital subtraction angiography, 35 @entity0 in our hospital were treated using various VBDA treatment strategies, including stent-assisted coil embolization (20 @entity0 ), placement of single or multiple overlapping stents (5 @entity0 ) or coil embolization combined with proximal coil trapping of the dissected segment of the parent artery (CE+PT; 10 @entity0 ). We retrospectively reviewed the perioperative records of all 35 @entity0 and the post-procedure angiographic and clinical outcomes of 31 available @entity0 . RESULTS: Of the 25 cases with ruptured VBDAs, 14 underwent stent-assisted coil embolization, 2 underwent multiple overlapping stent placement and 9 underwent CE+PT. Perioperative complications occurred in four cases (16.0%), including one @entity6 and one parent artery @entity5 during the procedure and two incidences of @entity1 after the procedure. Clinical outcome evaluations were performed using the Modified Rankin Scale and resulted in the following scores: 0-2 for 22 @entity0 (22/25, 88.0%), 5 for one @entity0 (1/25, 4.0%) and 6 for two @entity0 (2/25, 8.0%). No @entity7 events or @entity2 occurred during the follow-up period. Of the 10 cases with unruptured VBDAs, six underwent stent-assisted coil embolization, three underwent single or multiple overlapping stent placement and one @entity0 underwent CE+PT. All 10 of the @entity0 with unruptured VBDAs had favorable clinical and radiologic outcomes without procedure-related complications. CONCLUSIONS: For @entity0 with ruptured VBDAs, the complication rate associated with endovascular treatment is acceptable. CE+PT is better than stent coiling in preventing @entity4 , but is associated with a high incidence of @entity3 . For unruptured VBDAs, endovascular treatment is associated with good clinical outcome without perioperative complications, including rerupture and @entity3 . However, the high postoperative recurrent @entity4 risk suggests the necessity of long-term angiographic follow-up monitoring of VBDA @entity0 who undergo endovascular treatments.

title: Long-term follow-up study of 35 cases after endovascular treatment for vertebrobasilar dissecting XXXX .

answer: @entity4


abstract: OBJECTIVE: Cerebrospinal fluid (CSF) overdrainage is a major problem in shunt therapy for @entity1 . The adjustable gravitational valve proSA allows for the first time a targeted compensation for overdrainage in the upright position without interfering with the differential pressure valve. To evaluate benefit, safety and reliability, the multicenter prospective registry PROSAIKA was conducted in 10 German neurosurgical centers. METHODS: Between March 2009 and July 2010, 120 hydrocephalic @entity0 undergoing first time shunt implantation or shunt revision using proSA entered the study. 93 @entity0 completed the 12 months follow-up. RESULTS: @entity1 symptoms were improved in 86%, unchanged in 9% and deteriorated in 3%. In 51%, the proSA opening pressure was readjusted one or several times to treat suspected suboptimal shunt function, this resulted in clinical improvement in 55%, no change in 25%, and deterioration in 20% of these @entity0 . The 1 year censored proSA shunt survival rate was 89%. Device related shunt failure was seen in two cases. CONCLUSIONS: This is the first clinical report on the implantation of the adjustable gravitational valve proSA with a follow-up of 12 months in a substantial number of @entity0 . Irrespective of different @entity1 etiologies and indications for shunt surgery, the overall results after 12 months were very satisfying. The high frequency of valve readjustments underlines the fact that preoperative selection of the appropriate valve opening pressure is difficult. The low number of revisions and complications compared to other valves proves that proSA implantation adds no further risk; this valve is reliable, helpful and safe.

title: PROSAIKA: a prospective multicenter registry with the first programmable gravitational device for XXXX shunting.

answer: @entity1


abstract: The soluble glycoprotein sCD14 binds lipopolysaccharide, a complex that activates endothelial cells and that may be crucial in gram-negative @entity1 . Therefore, serum sCD14 was analyzed in 54 @entity0 with gram-negative @entity2 and in 26 healthy controls. sCD14 was tested by ELISA and Western blotting. @entity0 had higher sCD14 concentrations than controls (median, 3.23 vs. 2.48 micrograms/mL, P = .002). Increased levels were associated with high mortality (median, 4.2 micrograms/mL in nonsurvivors vs. 2.8 micrograms/mL in survivors, P = .001). sCD14 was found in two isoforms (49 and 55 kDa) in monocyte cultures. In sera only one of either form was detectable. Controls had the 49-kDa form, and @entity0 had either the 49- or 55-kDa form, but @entity0 with high levels of sCD14 had only the 55-kDa form. Twenty-one (53%) of 39 with the 55-kDa form and 8 (57%) of 14 with the 49-kDa form died. Thus, the level of sCD14 but not its biochemical form had a prognostic value in @entity0 with gram-negative @entity2 .

title: Increased circulating soluble CD14 is associated with high mortality in gram-negative XXXX .

answer: @entity2


abstract: @entity0 of the nail cuticle of @entity5 deficient @entity1 was used to study the evolution of the morphological changes occurring within the forming and formed haemostatic plug at the site of @entity3 . The morphological changes occurring were documented by light and @entity4 ( @entity4 ). Randomized measurements were made of the distances between adjacent platelets as a function of platelet interdigitation or compaction and the degree of dilatation of the open canalicular system (OCS) was used as an indicator of the degree of platelet activation. Fibrin deposition was noted both in terms of its location and the point in time at which it first appeared. @entity4 demonstrated major differences between the @entity5 deficient and the normal and factor VII deficient groups. In the normal animals the intermembrane distance showed noticeable changes with the platelets becoming tightly interdigitated at the time @entity2 stopped. During the same period the OCS became dilated. These changes, which were not seen in the @entity5 deficient animals, continued until many platelets lost their intracellular content and became balloon cells or ghosts and fibrinous transformation became prominent. Although those events did occur in the factor VII deficient state, each was delayed and resulted in significant differences between the factor VII and normal animals suggesting that the extrinsic pathway may play an important role in initiating the changes noted. The results suggested that the generation of thrombin and/or factor Xa is essential to promote the initial stabilization of the platelet plug as well as initiating its subsequent consolidation by fibrinous transformation.

title: A detailed morphological evaluation of the evolution of the haemostatic plug in normal, factor XXXX deficient @entity1 .

answer: @entity5


abstract: @entity0 of the nail cuticle of @entity5 deficient @entity1 was used to study the evolution of the morphological changes occurring within the forming and formed haemostatic plug at the site of @entity3 . The morphological changes occurring were documented by light and @entity4 ( @entity4 ). Randomized measurements were made of the distances between adjacent platelets as a function of platelet interdigitation or compaction and the degree of dilatation of the open canalicular system (OCS) was used as an indicator of the degree of platelet activation. Fibrin deposition was noted both in terms of its location and the point in time at which it first appeared. @entity4 demonstrated major differences between the @entity5 deficient and the normal and factor VII deficient groups. In the normal animals the intermembrane distance showed noticeable changes with the platelets becoming tightly interdigitated at the time @entity2 stopped. During the same period the OCS became dilated. These changes, which were not seen in the @entity5 deficient animals, continued until many platelets lost their intracellular content and became balloon cells or ghosts and fibrinous transformation became prominent. Although those events did occur in the factor VII deficient state, each was delayed and resulted in significant differences between the factor VII and normal animals suggesting that the extrinsic pathway may play an important role in initiating the changes noted. The results suggested that the generation of thrombin and/or factor Xa is essential to promote the initial stabilization of the platelet plug as well as initiating its subsequent consolidation by fibrinous transformation.

title: A detailed morphological evaluation of the evolution of the haemostatic plug in normal, factor @entity5 deficient XXXX .

answer: @entity1


abstract: STUDY DESIGN: Randomized clinical trial comparing two interventions in employees sick-listed 3 to 16 weeks because of @entity2 ( @entity2 ). OBJECTIVE: To compare 1-year return to work (RTW), @entity1 , disability and physical and mental health dimensions in subjects offered a hospital-based multidisciplinary intervention or a brief intervention. SUMMARY OF BACKGROUND DATA: Previous studies in sick-listed employees with @entity2 have indicated efficacy of both brief and more comprehensive multidisciplinary interventions. However, it remains unknown, which is the more effective, and which elements are instrumental in furthering RTW, and improving health. METHODS: The brief intervention comprised clinical examination and advice offered by a rehabilitation physician and a physiotherapist. In the multidisciplinary intervention, this intervention was supplemented with the expertise of a team and the assignment of a case manager who drew up a rehabilitation plan in collaboration with the @entity0 and the multidisciplinary team. One-year RTW was estimated by data from a comprehensive national database of social transfer payments. Questionnaires were used to obtain baseline and 1-year data on Roland Morris disability score, @entity2 Rating Scale, SF36, and fear-avoidance. RESULTS: A total of 351 @entity0 were included and randomized and 344 (98%) @entity0 participated in all the consultations according to the study protocol. RTW was achieved by 125 (71.0%) @entity0 in the multidisciplinary and 133 (76.0%) @entity0 in the brief intervention group. The hazard ratio was 0.84 after adjustment for sex, age, smoking, compensation claims, disability score, and diagnosis (95% confidence interval [CI]: 0.65-1.08,P = 0.18). Multiple linear regression analysis displayed no differences in secondary outcomes, except for the mental health score (SF36), which was a little higher in the multidisciplinary intervention group than in the brief intervention group. CONCLUSION: Hospital-based multidisciplinary intervention may be no better than brief intervention to increase RTW and improve health in sick-listed employees with @entity2 .

title: One-year follow-up in employees sick-listed because of XXXX : randomized clinical trial comparing multidisciplinary and brief intervention.

answer: @entity2


abstract: The diagnostic value of @entity8 -dependent lipase for @entity4 was tested in sera of 187 @entity0 . Of these @entity0 , 76 suffered from @entity6 , 43 from nonmalignant @entity3 ( @entity2 and @entity7 ), 18 from acute @entity5 , and 20 from chronic @entity5 . The remaining subjects were controls without pancreatic pathology. @entity8 -dependent lipase was determined by a sandwich enzyme-linked immunosorbent assay using polyclonal antibodies. Amylase and CA 19-9 antigen were also determined. In sera from control @entity0 , the mean level of @entity8 -dependent lipase was 1.5 micrograms/L. This level is quite similar to that of @entity0 with @entity3 (1.1 micrograms/L) and with chronic @entity5 (1.4 micrograms/L), but it was raised to 3.5 micrograms/L in @entity0 with acute @entity5 and decreased to 0.5 microgram/L in subjects with @entity5 . Thirty percent of control subjects and 73% of @entity1 @entity0 had a @entity8 -dependent lipase serum level below the cutoff value of 0.5 microgram/L. In acute @entity5 , 11 of 16 subjects had levels above 1.5 micrograms/L. Amylase level largely increased in acute @entity5 but was normal in all other groups. Concerning CA 19-9 antigen, 65% of control @entity0 and > 80% of @entity0 with nonmalignant pancreatic or @entity3 had normal levels. In sera from @entity1 @entity0 , 80% presented with high levels. Accordingly, 36 of 38 @entity0 with @entity5 had either low serum levels of @entity8 -dependent lipase (< 0.5 microgram/L) or high values of CA 19-9 antigen (> 37 U/ml; sensitivity 95%).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Is @entity8 -dependent lipase concentration in serum of any help in XXXX diagnosis?

answer: @entity5


abstract: The diagnostic value of @entity8 -dependent lipase for @entity4 was tested in sera of 187 @entity0 . Of these @entity0 , 76 suffered from @entity6 , 43 from nonmalignant @entity3 ( @entity2 and @entity7 ), 18 from acute @entity5 , and 20 from chronic @entity5 . The remaining subjects were controls without pancreatic pathology. @entity8 -dependent lipase was determined by a sandwich enzyme-linked immunosorbent assay using polyclonal antibodies. Amylase and CA 19-9 antigen were also determined. In sera from control @entity0 , the mean level of @entity8 -dependent lipase was 1.5 micrograms/L. This level is quite similar to that of @entity0 with @entity3 (1.1 micrograms/L) and with chronic @entity5 (1.4 micrograms/L), but it was raised to 3.5 micrograms/L in @entity0 with acute @entity5 and decreased to 0.5 microgram/L in subjects with @entity5 . Thirty percent of control subjects and 73% of @entity1 @entity0 had a @entity8 -dependent lipase serum level below the cutoff value of 0.5 microgram/L. In acute @entity5 , 11 of 16 subjects had levels above 1.5 micrograms/L. Amylase level largely increased in acute @entity5 but was normal in all other groups. Concerning CA 19-9 antigen, 65% of control @entity0 and > 80% of @entity0 with nonmalignant pancreatic or @entity3 had normal levels. In sera from @entity1 @entity0 , 80% presented with high levels. Accordingly, 36 of 38 @entity0 with @entity5 had either low serum levels of @entity8 -dependent lipase (< 0.5 microgram/L) or high values of CA 19-9 antigen (> 37 U/ml; sensitivity 95%).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Is XXXX -dependent lipase concentration in serum of any help in @entity5 diagnosis?

answer: @entity8


abstract: The present immunohistochemical study examines the expression of @entity7 , EGF, and the @entity3 in prostatic tissues obtained from @entity0 with either @entity4 ( @entity4 ) or @entity1 . Frozen sections were cut at 5 microns and were incubated with monoclonal antibodies directed against @entity7 , EGF, or the @entity3 . The remainder of the staining procedure was performed with an avidin- @entity5 -complex peroxidase procedure. Strong @entity7 expression was not detected in any of the 15 @entity4 specimens examined or in the normal/ @entity6 tissue intermixed within the @entity2 . In contrast, malignant cells in 9 of 11 @entity2 strongly expressed @entity7 . EGF reactivity was observed in both @entity6 and malignant epithelial tissues. @entity3 expression was strongest along the basal aspects of cells of normal or @entity6 glands. Although most malignant cells also were positive for the @entity3 the level of staining was less than that observed in cells forming normal or @entity6 glands. These results suggest that EGF and the @entity3 may be components of an autocrine/paracrine regulatory pathway involved in @entity6 and/or malignant disease of the prostate. The finding that @entity7 is expressed only in malignant cells suggests that @entity7 may represent a locally active autocrine regulator of malignant prostate cells.

title: Expression of transforming growth factor-alpha, epidermal growth factor and the @entity3 in XXXX and @entity4 .

answer: @entity1


abstract: The present immunohistochemical study examines the expression of @entity7 , EGF, and the @entity3 in prostatic tissues obtained from @entity0 with either @entity4 ( @entity4 ) or @entity1 . Frozen sections were cut at 5 microns and were incubated with monoclonal antibodies directed against @entity7 , EGF, or the @entity3 . The remainder of the staining procedure was performed with an avidin- @entity5 -complex peroxidase procedure. Strong @entity7 expression was not detected in any of the 15 @entity4 specimens examined or in the normal/ @entity6 tissue intermixed within the @entity2 . In contrast, malignant cells in 9 of 11 @entity2 strongly expressed @entity7 . EGF reactivity was observed in both @entity6 and malignant epithelial tissues. @entity3 expression was strongest along the basal aspects of cells of normal or @entity6 glands. Although most malignant cells also were positive for the @entity3 the level of staining was less than that observed in cells forming normal or @entity6 glands. These results suggest that EGF and the @entity3 may be components of an autocrine/paracrine regulatory pathway involved in @entity6 and/or malignant disease of the prostate. The finding that @entity7 is expressed only in malignant cells suggests that @entity7 may represent a locally active autocrine regulator of malignant prostate cells.

title: Expression of transforming growth factor-alpha, epidermal growth factor and the XXXX in @entity1 and @entity4 .

answer: @entity3


abstract: The present immunohistochemical study examines the expression of @entity7 , EGF, and the @entity3 in prostatic tissues obtained from @entity0 with either @entity4 ( @entity4 ) or @entity1 . Frozen sections were cut at 5 microns and were incubated with monoclonal antibodies directed against @entity7 , EGF, or the @entity3 . The remainder of the staining procedure was performed with an avidin- @entity5 -complex peroxidase procedure. Strong @entity7 expression was not detected in any of the 15 @entity4 specimens examined or in the normal/ @entity6 tissue intermixed within the @entity2 . In contrast, malignant cells in 9 of 11 @entity2 strongly expressed @entity7 . EGF reactivity was observed in both @entity6 and malignant epithelial tissues. @entity3 expression was strongest along the basal aspects of cells of normal or @entity6 glands. Although most malignant cells also were positive for the @entity3 the level of staining was less than that observed in cells forming normal or @entity6 glands. These results suggest that EGF and the @entity3 may be components of an autocrine/paracrine regulatory pathway involved in @entity6 and/or malignant disease of the prostate. The finding that @entity7 is expressed only in malignant cells suggests that @entity7 may represent a locally active autocrine regulator of malignant prostate cells.

title: Expression of transforming growth factor-alpha, epidermal growth factor and the @entity3 in @entity1 and XXXX .

answer: @entity4


abstract: The @entity0 oral microbial biota represents a highly diverse biofilm. Twenty-five species of oral streptococci inhabit the @entity0 oral cavity and represent about 20 % of the total oral bacteria. Taxonomy of these bacteria is complex and remains provisional. @entity3 . Each species has developed specific properties for colonizing the different oral sites subjected to constantly changing conditions, for competing against competitors, and for resisting external agressions (host immune system, physico-chemical shocks, and mechanical frictions). Imbalance in the indigenous microbial biota generates @entity1 , and under proper conditions, commensal streptococci can switch to opportunistic pathogens that @entity1 in and damage to the host. The group of "mutans streptococci" was described as the most important bacteria related to the formation of @entity2 . @entity4 , although naturally present among the @entity0 oral microbiota, is the microbial species most strongly associated with @entity2 . This minireview describes the oral streptococci ecology and their biofilm life style by focusing on the mutans group, mainly @entity4 . Virulence traits, interactions in the biofilm, and influence of @entity4 in @entity2 etiology are discussed.

title: [ XXXX and oral streptococci in dental plaque].

answer: @entity4


abstract: BACKGROUND: Epidural @entity1 injection is an established treatment modality for @entity9 leading to @entity6 . In cases where two levels of @entity6 are present, two separate injections are warranted. Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, @entity7 and @entity8 , and table tilt for management of both @entity6 . METHODS: 50 @entity0 of either sex aged between 35-65 years presenting with features of cervical and lumbar radiculopathic @entity2 were included and were subjected to single lumbar epidural injection of local anaesthetic, @entity7 and @entity8 , in the lateral position. The table was then tilted in the trendelberg position with a tilt of 25 degrees, and @entity0 were maintained for 10 minutes before being turned supine. All @entity0 were administered 3 such injections with an interval of 2 weeks between subsequent injections, and @entity2 relief was assessed with a visual analogue scale. Immediate complications after the block were assessed. RESULTS: Immediate and post procedural complications observed were @entity3 and @entity4 (20%), painful injection site (4%), @entity5 (10%) and high block (4%). @entity2 relief was assessed after the three injections by three grades: 37 (74%) had complete resolution of symptoms; 18% had partial relief and 8% did not benefit from the procedure. CONCLUSIONS: This technique may be used as an alternative technique for @entity2 relief in @entity0 with unilateral cervical and lumbar @entity6 .

title: Single shot epidural injection for cervical and XXXX : a preliminary study.

answer: @entity6


abstract: Changes in the expression of two isoenzymic forms of @entity1 kinase in fetal hepatocyte cultures derived from 15- and 19-day gestation @entity0 are studied by immunocytochemical localization of the respective antigens. Initially, in cultures established from 15-day gestation @entity0 only the 'embryonic' form of the enzyme (M2-PK) is detected in all cells. Cells which stain positively for the liver specific form of the enzyme ( @entity2 ) are not observed. After 2 days' culture, a significant number of cells have become positive for @entity2 . All the positive cells have a morphology which is typical of liver parenchymal cells. However, the majority of parenchymal cells remain negative for @entity2 while retaining M2-PK. In contrast, all cells which display a fibroblastic morphology, as well as clear epithelial cells are M2-PK positive, but @entity2 negative. In 5-day-old cultures, all hepatocytes have become @entity2 positive. Hepatocytes derived from 19-day gestation @entity0 liver stain positively for @entity2 on day 1 of culture in agreement with previously published biochemical data. A minor population of negative cells is non-parenchymal in appearance. All parenchymal cells are negative when the culture is stained with M2-PK specific antibody. Five days after the culture is established, many non-parenchymal cells are present. Such cells are @entity2 negative and M2-PK positive and their presence in cultures derived from both 15- and 19-day gestation @entity0 explains the persistence of M2-PK. This study reveals that during enzymic differentiation of fetal hepatocytes, all immature hepatocytes are initially capable of expressing M2-PK while they do not produce @entity2 . During culture, a sub-population of these cells initiates synthesis of @entity2 , indicating that only a fraction of the cells differentiate. At the same time, hepatocytes which do not stain for M2-PK appear, which suggests that cells which initiate @entity2 synthesis have ceased to make M2-PK. Eventually all hepatocytes are @entity2 positive and M2-PK negative, indicating that a switchover in expression of the @entity1 kinase isoenzymes has occurred.

title: XXXX kinase isoenzyme transitions in cultures of fetal @entity0 hepatocytes.

answer: @entity1


abstract: Changes in the expression of two isoenzymic forms of @entity1 kinase in fetal hepatocyte cultures derived from 15- and 19-day gestation @entity0 are studied by immunocytochemical localization of the respective antigens. Initially, in cultures established from 15-day gestation @entity0 only the 'embryonic' form of the enzyme (M2-PK) is detected in all cells. Cells which stain positively for the liver specific form of the enzyme ( @entity2 ) are not observed. After 2 days' culture, a significant number of cells have become positive for @entity2 . All the positive cells have a morphology which is typical of liver parenchymal cells. However, the majority of parenchymal cells remain negative for @entity2 while retaining M2-PK. In contrast, all cells which display a fibroblastic morphology, as well as clear epithelial cells are M2-PK positive, but @entity2 negative. In 5-day-old cultures, all hepatocytes have become @entity2 positive. Hepatocytes derived from 19-day gestation @entity0 liver stain positively for @entity2 on day 1 of culture in agreement with previously published biochemical data. A minor population of negative cells is non-parenchymal in appearance. All parenchymal cells are negative when the culture is stained with M2-PK specific antibody. Five days after the culture is established, many non-parenchymal cells are present. Such cells are @entity2 negative and M2-PK positive and their presence in cultures derived from both 15- and 19-day gestation @entity0 explains the persistence of M2-PK. This study reveals that during enzymic differentiation of fetal hepatocytes, all immature hepatocytes are initially capable of expressing M2-PK while they do not produce @entity2 . During culture, a sub-population of these cells initiates synthesis of @entity2 , indicating that only a fraction of the cells differentiate. At the same time, hepatocytes which do not stain for M2-PK appear, which suggests that cells which initiate @entity2 synthesis have ceased to make M2-PK. Eventually all hepatocytes are @entity2 positive and M2-PK negative, indicating that a switchover in expression of the @entity1 kinase isoenzymes has occurred.

title: @entity1 kinase isoenzyme transitions in cultures of fetal XXXX hepatocytes.

answer: @entity0


abstract: Precipitates were obtained by 6 N @entity4 hydrolysis of @entity0 erythrocytes and subsequent extractions with @entity2 -ether 1:1 and with @entity5 . The mean quantity of these precipitates (n = 16) was 16.60 +/- 1.60 (standard deviation) mg/ml, (15.09 +/- 1.45 mg/g) and from saline washed erythrocyte samples (n = 8) 16.65 +/- 0.73 mg/ml, (15.14 +/- 0.67 mg/g). A large part of these precipitates (about 74%) is associated with haemoglobin (in average 12.34 mg/ml). Melanins account for the difference (16.60-12.34) = 4.26 mg/ml, approximately 8.7% of haemoglobin-free erythrocyte solids. Precipitates from red cells, and from haemoglobin produced similar UV-VIS and IR spectra. The precipitates from haemoglobin are mainly derivatives of haeme (about 97%); the remaining approximately 3% are melanins from globin. The total melanins are about 1.3% of haeme-free solids of erythrocytes. Precipitation from the erythrocytes with 6 N @entity4 was also achieved in practically complete argon atmosphere, and similar quantities were obtained as those in air with the same UV-VIS and IR spectra. Since granules or solid particles are not found in the cytoplasm of normal @entity0 erythrocytes, we conclude that soluble melanins are present. Small amounts of melanins can be present in the membranes as well, since the precursors of @entity6 : @entity1 , @entity3 are present in these membranes.

title: Melanin quantitation from XXXX erythrocytes; interference by haeme derivatives.

answer: @entity0


abstract: BACKGROUND: The pedicled @entity5 flap has been a workhorse of autologous breast reconstruction for decades. However, there has been a rising concern about the abdominal wall donor site morbidity with the use of conventional @entity5 flap. This has generally been cited as one of the main reasons for resorting to "abdominal wall friendly" techniques. This study has been undertaken to assess the abdominal wall function in @entity0 with pedicled @entity5 flap breast reconstruction. The entire width of the muscle and the overlying wide disk of anterior rectus sheath were harvested with the @entity5 flap in all our @entity0 and the anterior rectus sheath defect was repaired by a @entity4 mesh. MATERIALS AND METHODS: Abdominal wall function was studied in 21 @entity0 who underwent simultaneous primary unipedicled @entity5 flap reconstruction after mastectomy for @entity1 . In all the @entity0 , the abdominal wall defect was repaired using wide sheet of @entity4 mesh both as inlay and onlay. The assessment tools included straight and rotational curl ups and a subjective questionnaire. The abdominal wall was also examined for any asymmetry, bulge, or @entity3 . The minimal follow-up was 6 months postoperative. The objective results were compared with normal unoperated volunteers. RESULTS AND CONCLUSIONS: The harvesting the @entity5 flap certainly results in changes to the anterior abdominal wall that can express themselves to a variable degree. A relatively high incidence of asymptomatic asymmetry of the abdomen was seen. There was total absence of @entity3 in our series even after a mean follow-up period of 15.5 months. A few @entity0 were only able to partially initiate the sit up movement and suffered an important loss of strength. In most @entity0 , synergists took over the functional movement but as the load increased, flexion and rotation performances decreased. The lack of correlation between exercise tests and the results of the questionnaire suggests that this statistically significant impairment was functionally not important. The @entity0 encountered little or no difficulty in theis day-to-day activities. Our modification of use of a wide mesh as inlay and onlay repair minimizes the donor site morbidity. This also avoids maneuvers meant for primary closure of the @entity2 , which can result in distortion of umbilicus. Therefore, in conclusion, the unipedicled @entity5 flap should be regarded as a valuable option in breast reconstruction provided careful repair of the abdominal wall defect is undertaken using @entity4 mesh.

title: Assessment of the abdominal wall function after pedicled XXXX flap surgery for breast reconstruction: Use of modified mesh repair for the donor defect.

answer: @entity5


abstract: Stent @entity2 (SF) has been implicated as a risk factor for in-stent @entity3 , but its incidence and clinical characteristics are not well established. Therefore we investigated the conditions associated with stent @entity2 and its clinical presentation and outcome. Between 2004 and 2007, consecutive cases of SF were collected from the Seoul National University Hospital. Clinical characteristics and outcome of @entity0 with @entity2 stents were compared with a ten-fold cohort of age and gender matched controls (n = 236). A total of 4,845 @entity0 received percutaneous coronary intervention and 3,315 @entity0 (68.4%) underwent angiographic follow-up. Twenty-eight @entity2 stents were observed in 24 @entity0 . The incidence of SF was 0.89% for @entity6 -eluting stents (SES) and 0.09% for @entity5 -eluting stents. @entity4 , stent implantation in the right coronary artery (RCA), and SES use were independent predictors of drug-eluting stent @entity2 by multivariate analysis. SF was significantly associated with binary @entity3 (11.4% vs 41.7%, P < 0.001) and increased risk of @entity1 revascularization (8.1% vs 33.3%, P = 0.001). @entity0 with SF but without significant @entity3 showed excellent outcome despite only medical treatment. In conclusion, SF is associated with increased rates of @entity3 and repeat revascularization. Significant risk factors include @entity4 , RCA intervention, and SES use.

title: Clinical characteristics of coronary drug-eluting stent XXXX : insights from a two-center des registry.

answer: @entity2


abstract: The maternal mRNA D7 is a moderately abundant transcript in @entity2 whose expression is highest in, and perhaps restricted to, oogenesis and early embryogenesis. The @entity0 sequence of cloned D7 cDNA was determined and shown to have the capacity to code for a 31-kD protein. This @entity1 sequence was searched against a protein data base, and no homologous proteins were found. Antibodies directed against D7 recognize in @entity2 embryos a soluble, cytoplasmic protein with an apparent molecular weight on SDS gels of 36,000. The @entity4 is absent from oocytes and first begins to accumulate during oocyte maturation. Its levels are highest during the first day of embryonic development and then decrease; @entity4 was not detected in adult tissues. D7 mRNA was selectively destroyed by injection into oocytes of antisense oligodeoxynucleotides. Analysis of injected oocytes by Northern and Western blotting showed site-specific cleavage and subsequent degradation of the D7 mRNA and the failure of the @entity4 to accumulate during @entity3 -induced maturation. The loss of @entity4 affects the maturation process itself, significantly delaying the time course of germinal vesicle breakdown. Thus, D7 is a newly described protein involved in oocyte maturation.

title: Destruction of a translationally controlled mRNA in XXXX oocytes delays @entity3 -induced maturation.

answer: @entity2


abstract: The maternal mRNA D7 is a moderately abundant transcript in @entity2 whose expression is highest in, and perhaps restricted to, oogenesis and early embryogenesis. The @entity0 sequence of cloned D7 cDNA was determined and shown to have the capacity to code for a 31-kD protein. This @entity1 sequence was searched against a protein data base, and no homologous proteins were found. Antibodies directed against D7 recognize in @entity2 embryos a soluble, cytoplasmic protein with an apparent molecular weight on SDS gels of 36,000. The @entity4 is absent from oocytes and first begins to accumulate during oocyte maturation. Its levels are highest during the first day of embryonic development and then decrease; @entity4 was not detected in adult tissues. D7 mRNA was selectively destroyed by injection into oocytes of antisense oligodeoxynucleotides. Analysis of injected oocytes by Northern and Western blotting showed site-specific cleavage and subsequent degradation of the D7 mRNA and the failure of the @entity4 to accumulate during @entity3 -induced maturation. The loss of @entity4 affects the maturation process itself, significantly delaying the time course of germinal vesicle breakdown. Thus, D7 is a newly described protein involved in oocyte maturation.

title: Destruction of a translationally controlled mRNA in @entity2 oocytes delays XXXX -induced maturation.

answer: @entity3


abstract: Twenty-eight consecutive adult @entity0 with locally advanced (inoperable) or metastatic soft tissue @entity5 were treated with a chemotherapy regimen (CADOM) including @entity6 , ADR, and DTIC on Day 1 of each course, and @entity11 with intermediate-dose @entity9 (200 mg/m2) on Day 15 followed by leucovorin rescue. Twenty-four of the @entity0 were evaluable for response and @entity2 . Three (13%) achieved a CR after chemotherapy and 6 (25%) a PR. Two of the PRs were converted to CR after surgical @entity1 . All five @entity0 achieving a CR are alive 12 to 30 months after beginning chemotherapy. Median survival of @entity0 achieving a PR was 18 months and of @entity0 achieving an MR was 7 months. Three of five @entity0 with @entity5 arising from the female genitalia achieved a CR. No treatment-related @entity3 occurred. There were five instances of @entity8 and @entity4 . @entity7 , and @entity10 were common. @entity13 , @entity15 , @entity14 , and @entity12 were occasionally observed. The addition of @entity9 did not improve the response rate when compared with our previous CYV ADIC protocol.

title: @entity6 , adriamycin, DTIC and @entity11 with XXXX in the treatment of @entity5 .

answer: @entity9


abstract: Twenty-eight consecutive adult @entity0 with locally advanced (inoperable) or metastatic soft tissue @entity5 were treated with a chemotherapy regimen (CADOM) including @entity6 , ADR, and DTIC on Day 1 of each course, and @entity11 with intermediate-dose @entity9 (200 mg/m2) on Day 15 followed by leucovorin rescue. Twenty-four of the @entity0 were evaluable for response and @entity2 . Three (13%) achieved a CR after chemotherapy and 6 (25%) a PR. Two of the PRs were converted to CR after surgical @entity1 . All five @entity0 achieving a CR are alive 12 to 30 months after beginning chemotherapy. Median survival of @entity0 achieving a PR was 18 months and of @entity0 achieving an MR was 7 months. Three of five @entity0 with @entity5 arising from the female genitalia achieved a CR. No treatment-related @entity3 occurred. There were five instances of @entity8 and @entity4 . @entity7 , and @entity10 were common. @entity13 , @entity15 , @entity14 , and @entity12 were occasionally observed. The addition of @entity9 did not improve the response rate when compared with our previous CYV ADIC protocol.

title: @entity6 , adriamycin, DTIC and @entity11 with @entity9 in the treatment of XXXX .

answer: @entity5


abstract: Twenty-eight consecutive adult @entity0 with locally advanced (inoperable) or metastatic soft tissue @entity5 were treated with a chemotherapy regimen (CADOM) including @entity6 , ADR, and DTIC on Day 1 of each course, and @entity11 with intermediate-dose @entity9 (200 mg/m2) on Day 15 followed by leucovorin rescue. Twenty-four of the @entity0 were evaluable for response and @entity2 . Three (13%) achieved a CR after chemotherapy and 6 (25%) a PR. Two of the PRs were converted to CR after surgical @entity1 . All five @entity0 achieving a CR are alive 12 to 30 months after beginning chemotherapy. Median survival of @entity0 achieving a PR was 18 months and of @entity0 achieving an MR was 7 months. Three of five @entity0 with @entity5 arising from the female genitalia achieved a CR. No treatment-related @entity3 occurred. There were five instances of @entity8 and @entity4 . @entity7 , and @entity10 were common. @entity13 , @entity15 , @entity14 , and @entity12 were occasionally observed. The addition of @entity9 did not improve the response rate when compared with our previous CYV ADIC protocol.

title: @entity6 , adriamycin, DTIC and XXXX with @entity9 in the treatment of @entity5 .

answer: @entity11


abstract: Twenty-eight consecutive adult @entity0 with locally advanced (inoperable) or metastatic soft tissue @entity5 were treated with a chemotherapy regimen (CADOM) including @entity6 , ADR, and DTIC on Day 1 of each course, and @entity11 with intermediate-dose @entity9 (200 mg/m2) on Day 15 followed by leucovorin rescue. Twenty-four of the @entity0 were evaluable for response and @entity2 . Three (13%) achieved a CR after chemotherapy and 6 (25%) a PR. Two of the PRs were converted to CR after surgical @entity1 . All five @entity0 achieving a CR are alive 12 to 30 months after beginning chemotherapy. Median survival of @entity0 achieving a PR was 18 months and of @entity0 achieving an MR was 7 months. Three of five @entity0 with @entity5 arising from the female genitalia achieved a CR. No treatment-related @entity3 occurred. There were five instances of @entity8 and @entity4 . @entity7 , and @entity10 were common. @entity13 , @entity15 , @entity14 , and @entity12 were occasionally observed. The addition of @entity9 did not improve the response rate when compared with our previous CYV ADIC protocol.

title: XXXX , adriamycin, DTIC and @entity11 with @entity9 in the treatment of @entity5 .

answer: @entity6


abstract: @entity3 occur frequently in @entity0 with @entity1 left ventricular (LV) @entity5 and have been associated with increased incidence of @entity4 . In this study, the effect of various antihypertensive medications on @entity3 was evaluated in 31 @entity1 @entity0 with moderate to severe @entity8 . @entity0 were assessed at baseline (after 3 weeks of placebo treatment) and after treatment with each of 4 monotherapies: @entity7 120 or 240 mg/day, @entity6 100 or 200 mg/day, @entity9 10 or 20 mg/day and @entity2 50 or 100 mg/day. Each drug therapy was administered for 4 weeks. The sequence of each treatment was determined at random. Echocardiographic measurements and electrocardiograms were obtained only at baseline. Biochemical measurements and 48-hour Holter monitoring were obtained at baseline and at the end of each treatment. All treatments resulted in a significant but similar decrease in blood pressure. In the group as a whole @entity7 decreased ventricular premature complexes (VPCs) by 65% (p < 0.05) and @entity6 by 52% (p = 0.07). @entity9 and @entity2 had no effect. In 12 @entity0 with > or = 5 VPCs/hour at baseline, @entity7 and @entity6 decreased VPCs by 66% (p < 0.05). It is concluded that in @entity1 @entity0 with moderate to severe @entity8 , both @entity7 and @entity6 significantly reduce VPCs.

title: Effects of @entity7 , @entity6 , XXXX and @entity2 on frequency of ventricular premature complexes.

answer: @entity9


abstract: @entity3 occur frequently in @entity0 with @entity1 left ventricular (LV) @entity5 and have been associated with increased incidence of @entity4 . In this study, the effect of various antihypertensive medications on @entity3 was evaluated in 31 @entity1 @entity0 with moderate to severe @entity8 . @entity0 were assessed at baseline (after 3 weeks of placebo treatment) and after treatment with each of 4 monotherapies: @entity7 120 or 240 mg/day, @entity6 100 or 200 mg/day, @entity9 10 or 20 mg/day and @entity2 50 or 100 mg/day. Each drug therapy was administered for 4 weeks. The sequence of each treatment was determined at random. Echocardiographic measurements and electrocardiograms were obtained only at baseline. Biochemical measurements and 48-hour Holter monitoring were obtained at baseline and at the end of each treatment. All treatments resulted in a significant but similar decrease in blood pressure. In the group as a whole @entity7 decreased ventricular premature complexes (VPCs) by 65% (p < 0.05) and @entity6 by 52% (p = 0.07). @entity9 and @entity2 had no effect. In 12 @entity0 with > or = 5 VPCs/hour at baseline, @entity7 and @entity6 decreased VPCs by 66% (p < 0.05). It is concluded that in @entity1 @entity0 with moderate to severe @entity8 , both @entity7 and @entity6 significantly reduce VPCs.

title: Effects of @entity7 , XXXX , @entity9 and @entity2 on frequency of ventricular premature complexes.

answer: @entity6


abstract: @entity3 occur frequently in @entity0 with @entity1 left ventricular (LV) @entity5 and have been associated with increased incidence of @entity4 . In this study, the effect of various antihypertensive medications on @entity3 was evaluated in 31 @entity1 @entity0 with moderate to severe @entity8 . @entity0 were assessed at baseline (after 3 weeks of placebo treatment) and after treatment with each of 4 monotherapies: @entity7 120 or 240 mg/day, @entity6 100 or 200 mg/day, @entity9 10 or 20 mg/day and @entity2 50 or 100 mg/day. Each drug therapy was administered for 4 weeks. The sequence of each treatment was determined at random. Echocardiographic measurements and electrocardiograms were obtained only at baseline. Biochemical measurements and 48-hour Holter monitoring were obtained at baseline and at the end of each treatment. All treatments resulted in a significant but similar decrease in blood pressure. In the group as a whole @entity7 decreased ventricular premature complexes (VPCs) by 65% (p < 0.05) and @entity6 by 52% (p = 0.07). @entity9 and @entity2 had no effect. In 12 @entity0 with > or = 5 VPCs/hour at baseline, @entity7 and @entity6 decreased VPCs by 66% (p < 0.05). It is concluded that in @entity1 @entity0 with moderate to severe @entity8 , both @entity7 and @entity6 significantly reduce VPCs.

title: Effects of XXXX , @entity6 , @entity9 and @entity2 on frequency of ventricular premature complexes.

answer: @entity7


abstract: @entity3 occur frequently in @entity0 with @entity1 left ventricular (LV) @entity5 and have been associated with increased incidence of @entity4 . In this study, the effect of various antihypertensive medications on @entity3 was evaluated in 31 @entity1 @entity0 with moderate to severe @entity8 . @entity0 were assessed at baseline (after 3 weeks of placebo treatment) and after treatment with each of 4 monotherapies: @entity7 120 or 240 mg/day, @entity6 100 or 200 mg/day, @entity9 10 or 20 mg/day and @entity2 50 or 100 mg/day. Each drug therapy was administered for 4 weeks. The sequence of each treatment was determined at random. Echocardiographic measurements and electrocardiograms were obtained only at baseline. Biochemical measurements and 48-hour Holter monitoring were obtained at baseline and at the end of each treatment. All treatments resulted in a significant but similar decrease in blood pressure. In the group as a whole @entity7 decreased ventricular premature complexes (VPCs) by 65% (p < 0.05) and @entity6 by 52% (p = 0.07). @entity9 and @entity2 had no effect. In 12 @entity0 with > or = 5 VPCs/hour at baseline, @entity7 and @entity6 decreased VPCs by 66% (p < 0.05). It is concluded that in @entity1 @entity0 with moderate to severe @entity8 , both @entity7 and @entity6 significantly reduce VPCs.

title: Effects of @entity7 , @entity6 , @entity9 and XXXX on frequency of ventricular premature complexes.

answer: @entity2


abstract: This report describes our experience with 16 @entity0 and @entity0 with a mean age of 7 months and a median age of 6 weeks with @entity1 . Fifteen @entity0 presented with @entity3 . Seven had @entity4 and four had associated cutaneous lesions. Although diagnosis was clinically evident in 15 of the 16 @entity0 , arteriography and computerized tomography (CT) were diagnostic. A variety of treatment approaches were used including radiation, resection, systemic @entity2 , hepatic artery ligation, angiographic embolization, and various combinations of these modalities. The following information was gained from this experience. CT with enhancement is as specific a diagnostic tool as hepatic arteriography. Angiographic and CT appearances do not correlate with prognosis. Most @entity0 can be treated successfully with @entity2 ; those who do not respond should have other approaches tried such as embolization or ligation. The angiographic appearance determines whether embolization therapy is worthwhile, as we found that hemangioendotheliomatosis with portal as well as hepatic arterial supply will not respond to embolization. The survival rate in this series was 80%.

title: Experience with XXXX in infancy and childhood.

answer: @entity1


abstract: Five cases of @entity4 with divergent differentiation are reported. All @entity0 were of male sex. They were 10, 15, 20, 21, and 30 years of age at time of diagnosis, respectively. By light microscopy, the @entity1 consisted of small cells arranged in groups, nests, and clusters separated by a collagen-rich @entity4 . Immunohistochemical studies revealed the coexpression of mesenchymal, epithelial, and neural markers. Notably, all @entity1 coexpressed @entity5 , cytokeratin, and @entity6 , the latter in a remarkable paranuclear dot-like fashion. In contrast to other authors, we did not find chromogranin. DNA image cytometry on four cases demonstrated two diploid and two aneuploid ( @entity3 ) cases. No correlation was found between ploidy and prognosis. One @entity0 died from disease, another died from @entity7 after bone marrow transplantation, and the remaining @entity0 are alive, but have progressive @entity2 . Thus, our findings support the poor prognosis in this type of @entity1 .

title: Intraabdominal XXXX with divergent differentiation: clinicopathological findings and DNA ploidy.

answer: @entity4


abstract: One hundred forty-one @entity1 @entity3 were analyzed for keratin (K) 6, 13 and 19. Staining was evaluated by light microscopy (with or without grading) and image analyzer and expressed as a percentage of positive versus all @entity0 surface (PSA). Both techniques rendered strongly correlated results. Strong expression was noted in 108 @entity2 (76.1%) for K6, in 18 (12.7%) for @entity4 and in 21 (14.8%) for @entity5 (P = .001). One hundred thirty-six (96%) @entity0 were positive for K6, and their PSA ranged from 0.6% to 48.8%; @entity4 , 48 cases (0.2-44%); @entity5 , 59 (0.2-38.1%). Expression of K6 was related to differentiation. @entity4 was expressed mainly in moderately and poorly differentiated @entity0 , and @entity5 was manifest more in well-differentiated @entity2 or in keratinized areas of less-differentiated ones. Nineteen (13.38%) @entity0 were positive for both @entity5 and @entity4 . @entity4 thus was related to @entity0 progression and @entity5 to differentiation. There was no correlation with @entity0 site or TNM category.

title: Keratins 6, 13 and 19. Differential expression in XXXX of the @entity1 .

answer: @entity3


abstract: One hundred forty-one @entity1 @entity3 were analyzed for keratin (K) 6, 13 and 19. Staining was evaluated by light microscopy (with or without grading) and image analyzer and expressed as a percentage of positive versus all @entity0 surface (PSA). Both techniques rendered strongly correlated results. Strong expression was noted in 108 @entity2 (76.1%) for K6, in 18 (12.7%) for @entity4 and in 21 (14.8%) for @entity5 (P = .001). One hundred thirty-six (96%) @entity0 were positive for K6, and their PSA ranged from 0.6% to 48.8%; @entity4 , 48 cases (0.2-44%); @entity5 , 59 (0.2-38.1%). Expression of K6 was related to differentiation. @entity4 was expressed mainly in moderately and poorly differentiated @entity0 , and @entity5 was manifest more in well-differentiated @entity2 or in keratinized areas of less-differentiated ones. Nineteen (13.38%) @entity0 were positive for both @entity5 and @entity4 . @entity4 thus was related to @entity0 progression and @entity5 to differentiation. There was no correlation with @entity0 site or TNM category.

title: Keratins 6, 13 and 19. Differential expression in @entity3 of the XXXX .

answer: @entity1


abstract: Forty-two @entity0 with advanced @entity5 were treated with a combination regimen of @entity6 180 mg and external irradiation 30-45 Gy. Twenty @entity0 had primary lesions, and 22 @entity0 had recurrent disease. Fifteen (75%) of the @entity0 with @entity1 showed objective response (five complete and ten partial response). Four underwent surgery. Of these, one is alive after 60 months with no evidence of disease. Two have died of unrelated causes without signs of recurrence. Seventeen relapsed and died of @entity3 . Median survival for @entity0 treated for @entity1 was 8.0 months. Thirteen (59%) of 22 @entity0 treated for recurrence showed objective response (two complete and eleven partial responses). None underwent surgery. All these @entity0 died of @entity3 . Median survival was 6.4 months. @entity2 was acceptable, and there were no treatment-related @entity4 . Even taking into account that our @entity0 had very advanced disease, the results are disappointing. An increase of the radiation dose beyond the maximum of 45 Gy given, and more aggressive surgery, might have improved the results.

title: Combined @entity6 and irradiation in preoperative treatment of advanced XXXX .

answer: @entity5


abstract: Forty-two @entity0 with advanced @entity5 were treated with a combination regimen of @entity6 180 mg and external irradiation 30-45 Gy. Twenty @entity0 had primary lesions, and 22 @entity0 had recurrent disease. Fifteen (75%) of the @entity0 with @entity1 showed objective response (five complete and ten partial response). Four underwent surgery. Of these, one is alive after 60 months with no evidence of disease. Two have died of unrelated causes without signs of recurrence. Seventeen relapsed and died of @entity3 . Median survival for @entity0 treated for @entity1 was 8.0 months. Thirteen (59%) of 22 @entity0 treated for recurrence showed objective response (two complete and eleven partial responses). None underwent surgery. All these @entity0 died of @entity3 . Median survival was 6.4 months. @entity2 was acceptable, and there were no treatment-related @entity4 . Even taking into account that our @entity0 had very advanced disease, the results are disappointing. An increase of the radiation dose beyond the maximum of 45 Gy given, and more aggressive surgery, might have improved the results.

title: Combined XXXX and irradiation in preoperative treatment of advanced @entity5 .

answer: @entity6


abstract: This study aimed to evaluate the effects of intravenous infusion of a @entity8 -based lipid emulsion on some blood energy-related metabolites and insulin sensitivity indexes in @entity4 . Four clinically healthy ewes were assigned into a 2-treatment, 2-period cross-over design. Either normal saline (NS) or lipid emulsion (LE) was intravenously introduced at a rate of 0.025  mL  kg(-1)  min(-1) for 6  h. The concentrations of blood nonesterified @entity5 (NEFA), @entity9 , @entity1 , @entity0 , @entity7 , @entity6 , @entity3 , @entity2 , and insulin were measured at different time points. After 6  h, intravenous @entity2 tolerance test was performed. Lipid infusion elicited an increase (P < 0.05) in the NEFA, @entity9 , and @entity1 concentrations compared with the baseline value and NS infusion. Infusion of NS did not influence blood @entity2 concentration; however, LE infusion increased plasma @entity2 concentration (P < 0.05). At time point 12  h, serum insulin concentrations were increased (P < 0.05) in NS treatment; however, such an increase was not observed in the LE treatment. Insulin sensitivity index for the LE infusion was lower (P < 0.05) than that for the NS treatment. The @entity2 effectiveness was not (P > 0.05) different among treatments. In the LE treatment, acute-phase insulin responses increased (P < 0.05) and disposition index decreased (P < 0.001) compared with NS treatment. The results showed that experimentally induced NEFA in blood could cause insulin resistance in @entity4 . The current model could be used to evaluate the pathogenesis of conditions associated with @entity10 and insulin resistance.

title: Experimental hyperlipidemia induces insulin resistance in XXXX .

answer: @entity4


abstract: BACKGROUND: @entity3 ( @entity3 ) is one of the most common @entity1 worldwide. The @entity5 gene is frequently mutated in some histological subtypes of @entity3 . The role of @entity5 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The @entity5 @entity1 suppressor gene @entity7 polymorphism has been associated with @entity3 . However, results were inconsistent. This meta-analysis was performed to estimate the association between @entity5 @entity7 polymorphism and @entity3 or @entity3 infected by @entity2 / @entity6 . METHODS: Electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of @entity7 were chosen, and pooled odds ratio (OR) with 95  % confidence interval (CI) was used to assess the association. RESULTS: Ten published studies, including 1,371 @entity3 cases and 2,517 controls were identified. The overall results suggested that the variant genotypes were associated with the @entity3 risk (Pro/Pro vs. Pro/ @entity4  +  @entity4 / @entity4 : OR 1.355, 95  % CI 1.041-1.764, p  =  0.024). In the stratified analysis, individuals with the Pro/Pro in the recessive model had increased risk of @entity3 (OR 1.927, 95  % CI 1.127-3.297, p  =  0.017) in Caucasian. A symmetric funnel plot, the Begg's test, was suggestive of the lack of publication bias. There was no association between the @entity5 codon 72 polymorphism and @entity2 / @entity6 -positive @entity3 . CONCLUSION: This meta-analysis suggests that @entity5 condon 72 Pro/Progenotypes are associated with increased risk of @entity3 in Caucasian. To validate this association, further studies with larger @entity0 worldwide are needed to examine the associations between this polymorphism and @entity3 .

title: XXXX codon 72 polymorphism and hepatocellular carcinoma: a meta-analysis.

answer: @entity5


abstract: AIMS: In adults requiring extracorporeal membrane oxygenation (ECMO), we wanted to determine; i) the frequency of elevated plasma free haemoglobin (PFHb), ii) the reasons for circuit changes and iii) whether elevated PFHb was associated with higher in-hospital mortality. MATERIALS AND METHODS: @entity0 requiring ECMO between January 2010 and August 2014 were identified from a prospectively collected ECMO database. Their scanned medical records and pathology results were reviewed. Relevant @entity0 , biochemical and circuit data were collected on an Excel spreadsheet and analysed using Stata 13 (StataCorp, College Station, TX). The @entity0 were analysed in three groups, depending on their peak PFHb during ECMO: 'Normal PFHb' (<0.1 g/L), 'Low level PFHb' (0.1 - 0.5 g/L), 'High level PFHb' (>0.5 g/L). MAIN RESULTS: There were 184 ECMO runs (56 VV, 128 VA) - 61 'Normal PFHb', 99 'Low level PFHb', 24 'High level PFHb'. Circuit @entity1 (pump, oxygenator) or haemolysis requiring exchanges were significantly more common in VV ECMO compared to VA ECMO - 23.21% (13/56) vs. 0.78% (1/128), p<0.001. Elevated PFHb was associated with a longer duration of haemofiltration (p<0.001) and ECMO support (p<0.001). In-hospital mortality rates for the 'Normal PFHb', 'Low level PFHb' and 'High level PFHb' groups were 16.39% (10/61), 30.30% (30/99) and 37.50% (9/24), respectively, p=0.067. CONCLUSION: Elevated PFHb values during adult ECMO were common. Severe haemolysis or @entity1 requiring circuit changes were uncommon and occurred almost exclusively on VV ECMO. There was a non-statistically significant increase in in-hospital mortality with elevated PFHb and studies of larger registry data may clarify the prognostic value of PFHb in adult @entity0 .

title: The meaning of a high plasma free haemoglobin: retrospective review of the prevalence of haemolysis and circuit XXXX in an adult ECMO centre over 5 years.

answer: @entity1


abstract: PURPOSE: @entity3 (IOP) is a risk factor for @entity1 . The principal outflow pathway for @entity4 in the @entity0 eye is through the trabecular meshwork (HTM) and Schlemm's canal (SC). The junction between the HTM and SC is thought to have a significant role in the regulation of IOP. A possible mechanism for the increased resistance to flow in @entity2 is an increase in stiffness (increased elastic modulus) of the HTM. In this study, the stiffness of the HTM in normal and glaucomatous tissue was compared, and a mathematical model was developed to predict the impact of changes in stiffness of the juxtacanalicular layer of HTM on flow dynamics through this region. METHODS: Atomic force microscopy (AFM) was used to measure the elastic modulus of normal and glaucomatous HTM. According to these results, a model was developed that simulated the juxtacanalicular layer of the HTM as a flexible membrane with embedded pores. RESULTS: The mean elastic modulus increased substantially in the glaucomatous HTM (mean = 80.8 kPa) compared with that in the normal HTM (mean = 4.0 kPa). Regional variation was identified across the glaucomatous HTM, possibly corresponding to the disease state. Mathematical modeling suggested an increased flow resistance with increasing HTM modulus. CONCLUSIONS: The data indicate that the stiffness of glaucomatous HTM is significantly increased compared with that of normal HTM. Modeling exercises support substantial impairment in outflow facility with increased HTM stiffness. Alterations in the biophysical attributes of the HTM may participate directly in the onset and progression of @entity1 .

title: Elastic modulus determination of normal and glaucomatous XXXX trabecular meshwork.

answer: @entity0


abstract: OBJECTIVE: To describe the incidence, ocular findings, and systemic associations of @entity7 in a population-based cohort of @entity0 . METHODS: We retrospectively reviewed the medical records of pediatric (aged <19 years) @entity0 diagnosed as having @entity7 from January 1, 1968, through December 31, 2007, as residents of Olmsted County, Minnesota. RESULTS: Thirty-three @entity0 were newly diagnosed as having @entity7 (annual incidence, 2.4 per 100,000 residents <19 years old; prevalence, 1 in 2077 live births). Median @entity0 age at diagnosis was 3.9 months (range, 2 days to 18.4 years), and 22 @entity0 (67%) had unilateral involvement. Twelve @entity0 (36%) had involvement of the anterior segment only, 13 (39%) of the posterior segment only, and 8 (24%) of both. During median ophthalmologic follow-up of 9.2 years (range, 13 days to 35.9 years), 19 @entity0 (58%) had other @entity6 , including amblyopia in 11 (33%) and strabismus in 10 (30%). During median medical follow-up of 16.8 years, 22 @entity0 (67%) were diagnosed as having a @entity1 , including abnormal development in 12 (36%) and @entity8 ( @entity7 , @entity2 , @entity9 , @entity4 and development, @entity3 , and @entity5 ) syndrome in 4 (12%). CONCLUSIONS: @entity7 occurred in 1 in 2077 live births. More than half of the @entity0 were diagnosed as having an @entity6 other than @entity7 , including strabismus and amblyopia in approximately one-third. Two-thirds of @entity0 were diagnosed as having a @entity1 , including @entity8 in 1 in 8 @entity0 .

title: Incidence, ocular findings, and systemic associations of XXXX : a population-based study.

answer: @entity7


abstract: @entity8 recognized during hospitalization for @entity3 ( @entity3 ) is common. It is a powerful predictor of worse prognosis in @entity0 both with and without previously known @entity1 . @entity8 during @entity3 is caused by an inflammatory and adrenergic response to ischemic stress, when @entity5 are released and glycogenolysis induced. The link between @entity8 and prognosis in @entity3 @entity0 is multi-factorial. @entity8 exerts detrimental effects on left ventricular and platelet function and it also activates other systemic pathological processes that contribute to cellular and tissue injury such as increasing oxidative stress and worsening endothelial function. @entity2 management strategies in @entity3 may improve outcome in @entity0 with @entity8 , by reducing inflammatory and clotting mediators, by improving endothelial function and fibrinolysis and by reducing @entity4 size. Most of available oral anti- @entity1 drugs are contraindicated for the increased risk of @entity7 . Thus, @entity6 is the preferred agent for glycemic control in @entity3 and conversion from intravenous to subcutaneous therapy commonly occurs when the critical acute phase of @entity3 resolves. Pharmacodynamics of @entity6 allows it to be adaptable to the changing physiology of the @entity3 @entity0 , is easily titrated and has no dosage threshold. Nevertheless, findings concerning the effect on @entity3 -related mortality of the control of @entity2 levels by intravenous infusion of @entity6 have been conflicting and intervention trials are needed to optimize the definition of @entity8 and to establish appropriate modalities and goals of @entity2 lowering treatment. In particular, the clinical benefit of an aggressive treatment with @entity6 is yet unproved.

title: Detrimental Effects of XXXX in Acute Coronary Syndromes: from Pathophysiological Mechanisms to Therapeutic Strategies.

answer: @entity8


abstract: Sequence-specific 1H and 15N resonance assignments have been determined for the major @entity2 protein (CspA) from @entity0 with recently developed three-dimensional triple-resonance NMR experiments. By use of these assignments, five antiparallel beta-strands were identified from analysis of NMR data. Strands 1-4 have a classical 3-2-1-4 Greek key beta-sheet topology and there are two beta-bulges, at positions Lys10-Trp11 and @entity4 65- @entity3 66. Three-dimensional structures of CspA were generated from NMR data by using simulated annealing with molecular dynamics. The overall chain fold of CspA is a beta-barrel structure, with a tightly packed hydrophobic core. Two-dimensional isotope-edited pulsed-field gradient 15N-1H heteronuclear single-quantum coherence spectroscopy was used to characterize the 15N-1H fingerprint spectrum with and without a 24-base oligodeoxyribonucleotide, 5'-AACGGTTTGACGTACAGACCATTA-3'. Protein-DNA complex formation perturbs a subset of the @entity5 resonances that are located mostly on one face of the CspA molecule. This portion of the CspA molecular surface includes two putative RNA-binding sequence motifs which contribute to an unusual cluster of eight surface aromatic side chains: Trp11, @entity1 12, @entity1 18, @entity1 20, @entity1 31, His33, @entity1 34, and Tyr42. These surface aromatic groups, and also residues Lys16, Ser44, and Lys60 located on this same face of CspA, are highly conserved in the family of CspA homologues. These isotope-edited pulsed-field gradient NMR data provide a low-resolution mapping of a DNA-binding epitope on CspA.

title: Solution NMR structure of the major @entity2 protein (CspA) from XXXX : identification of a binding epitope for DNA.

answer: @entity0


abstract: Sequence-specific 1H and 15N resonance assignments have been determined for the major @entity2 protein (CspA) from @entity0 with recently developed three-dimensional triple-resonance NMR experiments. By use of these assignments, five antiparallel beta-strands were identified from analysis of NMR data. Strands 1-4 have a classical 3-2-1-4 Greek key beta-sheet topology and there are two beta-bulges, at positions Lys10-Trp11 and @entity4 65- @entity3 66. Three-dimensional structures of CspA were generated from NMR data by using simulated annealing with molecular dynamics. The overall chain fold of CspA is a beta-barrel structure, with a tightly packed hydrophobic core. Two-dimensional isotope-edited pulsed-field gradient 15N-1H heteronuclear single-quantum coherence spectroscopy was used to characterize the 15N-1H fingerprint spectrum with and without a 24-base oligodeoxyribonucleotide, 5'-AACGGTTTGACGTACAGACCATTA-3'. Protein-DNA complex formation perturbs a subset of the @entity5 resonances that are located mostly on one face of the CspA molecule. This portion of the CspA molecular surface includes two putative RNA-binding sequence motifs which contribute to an unusual cluster of eight surface aromatic side chains: Trp11, @entity1 12, @entity1 18, @entity1 20, @entity1 31, His33, @entity1 34, and Tyr42. These surface aromatic groups, and also residues Lys16, Ser44, and Lys60 located on this same face of CspA, are highly conserved in the family of CspA homologues. These isotope-edited pulsed-field gradient NMR data provide a low-resolution mapping of a DNA-binding epitope on CspA.

title: Solution NMR structure of the major XXXX protein (CspA) from @entity0 : identification of a binding epitope for DNA.

answer: @entity2


abstract: Polyspecific IgG given intravenously at high dose (IVIG) are increasingly used as an immunomodulating therapy in @entity3 . However, very few studies have dealt with the action of IVIG on the expression of the leukocyte markers. During a clinical trial in which 13 young and healthy @entity0 received IVIG to prevent unexplained recurrent abortions we have evaluated by flow cytometry the action of IVIG on 17 @entity9 ( @entity4 ). We found that the IVIG perfusions (0.5 g/kg) induced an increase in the number of polymorphonuclear and monocyte cells in the peripheral blood. This effect lasted 8 days. The IVIG treatment had no effect upon T cell populations stained with antibodies specific for @entity11 , CD3, @entity1 , @entity2 and on @entity1 +CD45RA+, @entity1 + @entity8 +, @entity2 + @entity6 +, @entity2 + @entity6 - subpopulations. A weak decrease in the B cell number was observed. The most striking phenomenon was the decrease in the number of @entity10 + cells, whereas @entity12 + and @entity13 + cells were unaltered. By the double-staining technique we showed that @entity10 + @entity12 + cells became @entity10 - @entity12 + cells. Moreover, IVIG decrease the expression level of the @entity7 molecule on monocytes and lymphocytes. The other adhesion molecules studied remained steady ( @entity15 , @entity14 , @entity16 , @entity8 , @entity6 , and @entity5 ). This study has shown that IVIG have no effect on 15 of 17 @entity4 used but downmodulate two adhesion molecules playing a key role in the immune system.

title: Effects of intravenous immunoglobulins (IVIG) on peripheral blood B, NK, and T cell subpopulations in @entity0 with recurrent spontaneous abortions: specific effects on XXXX and @entity10 molecules.

answer: @entity7


abstract: Polyspecific IgG given intravenously at high dose (IVIG) are increasingly used as an immunomodulating therapy in @entity3 . However, very few studies have dealt with the action of IVIG on the expression of the leukocyte markers. During a clinical trial in which 13 young and healthy @entity0 received IVIG to prevent unexplained recurrent abortions we have evaluated by flow cytometry the action of IVIG on 17 @entity9 ( @entity4 ). We found that the IVIG perfusions (0.5 g/kg) induced an increase in the number of polymorphonuclear and monocyte cells in the peripheral blood. This effect lasted 8 days. The IVIG treatment had no effect upon T cell populations stained with antibodies specific for @entity11 , CD3, @entity1 , @entity2 and on @entity1 +CD45RA+, @entity1 + @entity8 +, @entity2 + @entity6 +, @entity2 + @entity6 - subpopulations. A weak decrease in the B cell number was observed. The most striking phenomenon was the decrease in the number of @entity10 + cells, whereas @entity12 + and @entity13 + cells were unaltered. By the double-staining technique we showed that @entity10 + @entity12 + cells became @entity10 - @entity12 + cells. Moreover, IVIG decrease the expression level of the @entity7 molecule on monocytes and lymphocytes. The other adhesion molecules studied remained steady ( @entity15 , @entity14 , @entity16 , @entity8 , @entity6 , and @entity5 ). This study has shown that IVIG have no effect on 15 of 17 @entity4 used but downmodulate two adhesion molecules playing a key role in the immune system.

title: Effects of intravenous immunoglobulins (IVIG) on peripheral blood B, NK, and T cell subpopulations in @entity0 with recurrent spontaneous abortions: specific effects on @entity7 and XXXX molecules.

answer: @entity10


abstract: Polyspecific IgG given intravenously at high dose (IVIG) are increasingly used as an immunomodulating therapy in @entity3 . However, very few studies have dealt with the action of IVIG on the expression of the leukocyte markers. During a clinical trial in which 13 young and healthy @entity0 received IVIG to prevent unexplained recurrent abortions we have evaluated by flow cytometry the action of IVIG on 17 @entity9 ( @entity4 ). We found that the IVIG perfusions (0.5 g/kg) induced an increase in the number of polymorphonuclear and monocyte cells in the peripheral blood. This effect lasted 8 days. The IVIG treatment had no effect upon T cell populations stained with antibodies specific for @entity11 , CD3, @entity1 , @entity2 and on @entity1 +CD45RA+, @entity1 + @entity8 +, @entity2 + @entity6 +, @entity2 + @entity6 - subpopulations. A weak decrease in the B cell number was observed. The most striking phenomenon was the decrease in the number of @entity10 + cells, whereas @entity12 + and @entity13 + cells were unaltered. By the double-staining technique we showed that @entity10 + @entity12 + cells became @entity10 - @entity12 + cells. Moreover, IVIG decrease the expression level of the @entity7 molecule on monocytes and lymphocytes. The other adhesion molecules studied remained steady ( @entity15 , @entity14 , @entity16 , @entity8 , @entity6 , and @entity5 ). This study has shown that IVIG have no effect on 15 of 17 @entity4 used but downmodulate two adhesion molecules playing a key role in the immune system.

title: Effects of intravenous immunoglobulins (IVIG) on peripheral blood B, NK, and T cell subpopulations in XXXX with recurrent spontaneous abortions: specific effects on @entity7 and @entity10 molecules.

answer: @entity0


abstract: The present study was carried out on the material of 486 @entity2 @entity0 who received radiotherapy and chemotherapy as adjuvant treatment at the Oncological Gynaecology Clinic at the Maria Sk  odowska-Curie @entity1 Center-Institute of Oncology in Warsaw in the period 1979-1985, following primary surgery. The clinical stage of disease advancement was determined on the basis of surgery protocols and histological examinations. Radiotherapy was the treatment of choice in @entity0 in stages I and II. Irradiation was applied to the pelvis minor and para aortal nodes (in @entity0 at stage Ia) or to fields covering the entire abdominal cavity (other @entity0 at stage I and II). Chemotherapy was given to stage III and IV @entity0 multi-drug therapy, usually including @entity5 , @entity3 , and @entity4 , or with one drug (monochemotherapy) with the alhylating agents. The largest group of @entity0 under study were @entity0 with @entity2 in stage I (38.8%), the smallest group consisted of @entity0 in stage IV (8.5%). @entity0 in stage III represented 37.5% of all the material. @entity0 aged 50-64 years were most frequently treated (47.3%), the least frequent group were the @entity0 aged over 65 (13.2%). The predominating histological diagnosis was serous cancer type (48.7%), clear-cell cancer was detected least frequently (13.2%). Among all the @entity0 treated 35.4% survived 5 years after treatment, 69% in stage I, 43.8% in stage II, 8.8% in stage III, and 2.5% in stage IV.

title: Clinical analysis and evaluation of the results of adjuvant treatment (radiotherapy and chemotherapy) in XXXX .

answer: @entity2


abstract: PURPOSE: Retrospective evaluation of 12-year experience with endovascular management of @entity4 ( @entity4 ) due to @entity2 of the @entity5 ( @entity5 ). MATERIALS AND METHODS: From 2003 to 2014, we analysed the in-hospital mortality of 37 @entity0 with acute @entity3 who underwent primary endovascular therapy with subsequent on-demand laparotomy. @entity3 was used in all 37 @entity0 (19 @entity0 , 18 @entity0 , median age 76  years) with @entity2 of the @entity5 . Adjunctive local thrombolysis (n  =  2) and stenting (n  =  2) were also utilised. RESULTS: We achieved complete recanalization of the @entity5 stem in 91.9  %. One @entity0 was successfully treated by surgical embolectomy due to a failed endovascular approach. Subsequent exploratory laparotomy was performed in 73.0  % (n  =  27), and @entity1 bowel resection in 40.5  %. The total in-hospital mortality was 27.0  %. CONCLUSION: Primary endovascular therapy for acute @entity2 with on-demand laparotomy is a recommended algorithm used in our centre to treat @entity2 . This combined approach for the treatment of @entity4 is associated with in-hospital mortality rate of 27.0  %.

title: Endovascular Management of Acute XXXX of the Superior Mesenteric Artery: A 12-Year Single-Centre Experience.

answer: @entity2


abstract: PURPOSE: The purpose of the study was to assess the safety and midterm effectiveness of endovascular treatment in Trans-Atlantic Inter-Society Consensus II (TASC-II) D femoropopliteal occlusions in @entity0 with @entity1 ( @entity1 ). METHODS: @entity0 with @entity1 who underwent endovascular treatment for TASC-D de novo femoropopliteal occlusive disease between September 2008 and December 2013 were selected. Data included anatomic features, pre- and postprocedure ankle-brachial index, duplex ultrasound, and periprocedural complications. Sustained clinical improvement, limb salvage rate, freedom from @entity2 revascularization (TLR), and freedom from target extremity revascularization (TER) were assessed by Kaplan-Meier estimation and predictors of @entity3 / @entity4 with Cox analysis. RESULTS: Thirty-two @entity0 underwent treatment of 35 TASC-D occlusions. Mean age was 76    9. Mean lesion length was 23    5 cm. Twenty-eight limbs (80 %) presented tissue loss. Seventeen limbs underwent treatment by stent, 13 by stent-graft, and 5 by angioplasty. Mean follow-up was 29    20 months. Seven @entity0 required major amputation and six @entity0 died during follow-up. Eighteen endovascular and three surgical TLR procedures were performed due to @entity3 or @entity4 . Estimated freedom from TLR and TER rates at 2 years were 41 and 76%, whereas estimated primary and secondary patency rates were 41 and 79%, respectively. CONCLUSIONS: Endovascular treatment for TASC II D lesions is safe and offers satisfying outcomes. This @entity0 subset would benefit from a minimally invasive approach. Follow-up is advisable due to a high rate of @entity3 . Further follow-up is necessary to know the long-term efficacy of these procedures.

title: Mid-Term Outcomes of Endovascular Treatment for TASC-II D @entity4 with XXXX .

answer: @entity1


abstract: PURPOSE: The purpose of the study was to assess the safety and midterm effectiveness of endovascular treatment in Trans-Atlantic Inter-Society Consensus II (TASC-II) D femoropopliteal occlusions in @entity0 with @entity1 ( @entity1 ). METHODS: @entity0 with @entity1 who underwent endovascular treatment for TASC-D de novo femoropopliteal occlusive disease between September 2008 and December 2013 were selected. Data included anatomic features, pre- and postprocedure ankle-brachial index, duplex ultrasound, and periprocedural complications. Sustained clinical improvement, limb salvage rate, freedom from @entity2 revascularization (TLR), and freedom from target extremity revascularization (TER) were assessed by Kaplan-Meier estimation and predictors of @entity3 / @entity4 with Cox analysis. RESULTS: Thirty-two @entity0 underwent treatment of 35 TASC-D occlusions. Mean age was 76    9. Mean lesion length was 23    5 cm. Twenty-eight limbs (80 %) presented tissue loss. Seventeen limbs underwent treatment by stent, 13 by stent-graft, and 5 by angioplasty. Mean follow-up was 29    20 months. Seven @entity0 required major amputation and six @entity0 died during follow-up. Eighteen endovascular and three surgical TLR procedures were performed due to @entity3 or @entity4 . Estimated freedom from TLR and TER rates at 2 years were 41 and 76%, whereas estimated primary and secondary patency rates were 41 and 79%, respectively. CONCLUSIONS: Endovascular treatment for TASC II D lesions is safe and offers satisfying outcomes. This @entity0 subset would benefit from a minimally invasive approach. Follow-up is advisable due to a high rate of @entity3 . Further follow-up is necessary to know the long-term efficacy of these procedures.

title: Mid-Term Outcomes of Endovascular Treatment for TASC-II D XXXX with @entity1 .

answer: @entity4


abstract: BACKGROUND: There is a lack of valid health care transition readiness (HCT) scales in Spanish. OBJECTIVE: To provide initial validation of the UNC TRxANSITION Scale    among Mexican adolescents and young adults (youth) with @entity1 ( @entity1 ). METHODS: We used the professionally translated/back translated, provider-administered UNC TRxANSITION Scale    (Ferris et al., 2012). This 33-question scale measures HCT in ten sub-scales including knowledge about diagnosis or treatment, diet, reproductive health, school/work, insurance, ability to self-manage and looking for new health providers. Its maximum score is 10. We enrolled 163 Mexican adolescents (48.5% females) with @entity1 stage>= 3, mean age of 15.1years (  2.1) and whose primary language is Spanish. There were 15 @entity0 on hemodialysis (9.2%) and 30 transplant recipients (18.4%). Results were compared to those reported in adolescents with chronic conditions from the USA. RESULTS: Our cohort's overall median total score was 5.9. @entity0 >= 16years old had a median total score of 6.4, whereas younger @entity0 had median score of 5.6 (p<0.05). Transplant @entity0 had greater scores in the total and the sub-scales of medication knowledge, issues of reproduction, insurance, trade/work and adherence (p<0.05). When comparing the total score (by age), results from our Mexican youth were similar to those reported in youth from the USA. CONCLUSIONS: In our Mexican cohort of youth with @entity1 , health care transition readiness is greater in older @entity0 and in transplant recipients. Our cohort's overall score is low, indicating the need for a health care transition preparation program. The UNC TRxANSITION Scale    results in Mexican youth with @entity1 are comparable to findings in youth from the USA.

title: Validation of the UNC TRxANSITION Scale   Version 3 Among Mexican Adolescents With XXXX .

answer: @entity1


abstract: PURPOSE: We already reported that levels of interferon (IFN)-y have been shown to be markedly reduced in @entity0 seven weeks after irradiation, resulting in a T helper (Th) 1/ @entity2 imbalance. To investigate whether the single or fractionated y-irradiation induced an immune imbalance, we analysed the @entity3 -related immune response profile until six months after the fractionated whole-body irradiation. METHODS AND MATERIALS: @entity0 were exposed to y-rays at a fractionated 5   Gy cumulative dose for five weeks. At two, four and six months later from the first exposure, experiments were performed. Cell populations in the spleen, the production of IFN-y, @entity1 and IL-12p70, natural killer (NK) cell activity and the expression of IL-12 receptors, @entity4 and @entity5 were detected. RESULTS: The IFN-y was lower in the @entity0 exposed by all irradiation conditions than in normal control @entity0 , but the @entity1 had increased in all the irradiated @entity0 . To investigate @entity3 profile, NK cell activity, IL-12p70 level and its receptor expression was confirmed. In all fractionated irradiation groups, the NK cell activity as well as the absolute numbers of NK cells was much decreased. Also, all the irradiated @entity0 showed a lower IL-12p70 level. However, the expression of IL-12 receptor b2 was lower in the irradiated @entity0 except the 0.2   Gy 10 @entity0 group. The phosphoylated @entity4 was lower in all the irradiated @entity0 . This suppression was associated with an overexpression of @entity5 . CONCLUSIONS: The fractionated whole-body irradiations of a dose of 5   Gy appear to be the down-regulation of the @entity3 -like immune response. These changes, in turn, maintain an immunological imbalance that persists in the long term.

title: Chronic effects of single and fractionated y-irradiation on an impairment of XXXX -related immune response.

answer: @entity3