abstract: OBJECTIVES: Hand dominance has been reported to be an important factor affecting outcomes after upper extremity @entity1 but remains unstudied after hemiarthroplasty for @entity2 . This study determined whether dominance affected outcomes after hemiarthroplasty for @entity2 . DESIGN: Retrospective cohort study. SETTING: Tertiary care referral center. @entity0 : Sixty-one @entity0 , after hemiarthroplasty for @entity2 , returned for comprehensive assessment and were divided into 2 groups: dominant (DOM) shoulder affected (n = 25) and non-dominant (non-DOM) shoulder affected (n = 36). INTERVENTION: @entity2 -specific proximal humeral hemiarthroplasty for displaced @entity2 . MAIN OUTCOME MEASURES: @entity0 were assessed with self-reported outcomes ( @entity3 , American Shoulder and Elbow Surgeons shoulder score, disability of the arm, shoulder, and hand questionnaire, simple shoulder test, and short form 12) and objective (range-of-motion and hand-held dynamometer strength) testing. RESULTS: At 49 months of mean follow-up, there were no significant differences between groups for gender, age, follow-up time, or @entity3 (P > 0.256). The DOM-affected group had significantly worse scores for American Shoulder and Elbow Surgeons shoulder score (P = 0.043), disability of the arm, shoulder, and hand questionnaire (P = 0.039), and simple shoulder test (P = 0.021). The DOM-affected group also had consistently higher correlations between self-reported and objective outcomes than the non-DOM group. CONCLUSIONS: @entity0 who underwent hemiarthroplasty for @entity2 on their DOM shoulders had significantly poorer outcomes than @entity0 with non-DOM-sided injuries. Although positive outcomes can be expected after hemiarthroplasty, @entity0 should be instructed that they may have less satisfactory function and strength if their injury was on the DOM side. LEVEL OF EVIDENCE: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

title: Outcomes After Hemiarthroplasty for Proximal Humerus XXXX Are Significantly Affected by Hand Dominance.

answer: @entity2


abstract: This study describes a noninvasive method for detecting delayed ventricular activation, caused by @entity0 , on the body surface. Signal averaging and a newly developed high-pass digital filter were used. The filter has the property that it does not create an artifact or ring after the QRS complex ends, thereby allowing the detection of microvolt-level potentials that occur immediately after the QRS complex. Eleven @entity1 were studied before and during acute @entity0 induced by coronary artery ligation and latex embolization. The @entity0 region was mapped with bipolar electrodes and, after the chest was rapidly closed, signal-averaged recordings were made from the body surface. Repeated cycles of ventricular mapping and signal averaging were performed. In each @entity1 , delayed and fractionated electrograms were recorded directly from the @entity0 epicardium that lasted a maximum of 118 +/- 18 ms after QRS onset. The duration of the ventricular electrograms varied with time. Whenever delayed epicardial electrograms were recorded, filtered signal-averaged leads showed microvolt-level potentials early in the S-T segment that were continuous with the QRS complex. The duration of ventricular activation, as measured from the bipolar electrograms and from the filtered signal-averaged leads, correlated well (r = 0.93, P less than 0.001). Because of the absence of filter ringing, low-level potentials could be detected less than 40 ms after the QRS complex ended. This study demonstrates that microvolt-level potentials arising from delayed ventricular activation can be reliably detected on the body surface, even when they occur just after the QRS complex.

title: Detection of delayed ventricular activation on the body surface in XXXX .

answer: @entity1


abstract: BACKGROUND: High levels of @entity1 during surgery are associated with poorer post-surgical outcomes. This prospective, non-blinded randomized controlled trial aimed to compare the effectiveness of four intraoperative distraction interventions for @entity1 and @entity2 management during minimally invasive venous surgery under local anaesthetic. METHODS: 407 @entity0 presenting with varicose veins at a private clinic, were randomized to one of four intraoperative distraction interventions or treatment as usual. All @entity0 received endovenous thermoablation and/or phlebectomies of varicose veins. After losses to follow-up, 398 @entity0 were entered into the analysis. @entity0 were randomly allocated to one of the following intraoperative distraction techniques: @entity0 selected music (n  =  85), @entity0 selected @entity3 (n  =  85), interaction with nurses (n  =  81), touch (stress balls) (n  =  80) or treatment as usual (TAU, n  =  76). The state scale of the STAI, the Short-form @entity2 questionnaire and numeric rating scales were used to assess intraoperative @entity2 and @entity1 . RESULTS: Intraoperative @entity1 ratings were significantly lower when @entity0 interacted with nurses, used stress balls or watched a @entity3 during surgery compared to treatment as usual. Intraoperative @entity2 ratings were significantly lower than treatment as usual when @entity0 interacted with nurses or used stress balls during surgery. @entity0 ' satisfaction was not significantly impacted by intraoperative distractions. CONCLUSIONS: The use of simple intraoperative distraction techniques, particularly interacting with nurses, using stress balls or watching a @entity3 during surgery conducted under local anaesthetic can significantly improve @entity0 ' experiences.

title: Randomized controlled trial to compare the effect of simple distraction interventions on @entity2 and XXXX experienced during conscious surgery.

answer: @entity1


abstract: BACKGROUND: High levels of @entity1 during surgery are associated with poorer post-surgical outcomes. This prospective, non-blinded randomized controlled trial aimed to compare the effectiveness of four intraoperative distraction interventions for @entity1 and @entity2 management during minimally invasive venous surgery under local anaesthetic. METHODS: 407 @entity0 presenting with varicose veins at a private clinic, were randomized to one of four intraoperative distraction interventions or treatment as usual. All @entity0 received endovenous thermoablation and/or phlebectomies of varicose veins. After losses to follow-up, 398 @entity0 were entered into the analysis. @entity0 were randomly allocated to one of the following intraoperative distraction techniques: @entity0 selected music (n  =  85), @entity0 selected @entity3 (n  =  85), interaction with nurses (n  =  81), touch (stress balls) (n  =  80) or treatment as usual (TAU, n  =  76). The state scale of the STAI, the Short-form @entity2 questionnaire and numeric rating scales were used to assess intraoperative @entity2 and @entity1 . RESULTS: Intraoperative @entity1 ratings were significantly lower when @entity0 interacted with nurses, used stress balls or watched a @entity3 during surgery compared to treatment as usual. Intraoperative @entity2 ratings were significantly lower than treatment as usual when @entity0 interacted with nurses or used stress balls during surgery. @entity0 ' satisfaction was not significantly impacted by intraoperative distractions. CONCLUSIONS: The use of simple intraoperative distraction techniques, particularly interacting with nurses, using stress balls or watching a @entity3 during surgery conducted under local anaesthetic can significantly improve @entity0 ' experiences.

title: Randomized controlled trial to compare the effect of simple distraction interventions on XXXX and @entity1 experienced during conscious surgery.

answer: @entity2


abstract: UNASSIGNED: The primary aim of this paper was to assess the relevance of high-frequency ultrasound examination in qualifying @entity0 for either surgical or conservative treatment of postoperative @entity4 . The study was conducted in a group of 71 @entity0 who in 2009-2011 were referred to ultrasound examinations due to a clinical suspicion of @entity4 . For the purposes of this analysis, the suspected @entity1 were divided into three groups: after surgical treatment of the median nerve (1), after surgical treatment of the ulnar nerve (2) and other @entity1 (3). All @entity0 underwent the interview, physical examination and ultrasound examination. The ultrasound examinations were performed with Esaote MyLab 50 and MyLab 60 systems. Based on the clinical and US examinations, the @entity0 were qualified for either surgical (51 cases) or conservative treatment (20 cases). An EMG examination was also performed in certain @entity0 (60 cases). Mean values of cross-sectional areas and diameters of the nerve trunks were calculated in individual pathology groups. The ultrasound features of the peripheral nerves analyzed in the study, such as echostructure, notch sign, @entity3 and continuity of the transverse ligament, were divided into subgroups. Moreover, the frequency of adhesions between the nerve trunks and adjacent tissues, occurrence of @entity2 on compression with a transducer and instability of the ulnar nerve as well as angulation of the posterior interosseous nerve in a dynamic examination was calculated. The analyses of the collected material were performed by means of descriptive statistics. The results of clinical and surgical verification were consistent with ultrasound findings in 100% of cases. The results indicate that high-frequency ultrasonography is a valuable method in qualifying @entity0 for various types of treatment of @entity4 .

title: Assessment of the utility of ultrasonography with high-frequency transducers in the diagnosis of XXXX .

answer: @entity1


abstract: UNASSIGNED: Angelica polymorpha Maxim root extract (APRE) is a popular herbal medicine used for treating stomachache, @entity2 , @entity9 , and @entity8 ; however the effect of APRE on @entity0 cells has not yet been explored. Here, we examined @entity1 seen on target @entity3 cells (NB) using cell viability assays, @entity13 visualization of fragmented DNA, and Western blotting analysis of candidate signaling pathways involved in proliferation and apoptosis. We demonstrated that APRE reduced cell viability in NB to a greater extent than in fibroblast cells. In addition, we found that APRE could inhibit the three classes of MAPK proteins and could also down-regulate the PI3K/ @entity5 / @entity12 activity all being relevant for proliferation and survival. APRE could also up-regulate @entity7 expression and down-regulate @entity6 and @entity10 . With APRE treatment, depolarization of mitochondria membrane potential and activation of @entity4 was demonstrated in the SH-SY5Y cells. We could not found increased activity of death receptor and @entity11 as markers of the extrinsic apoptosis pathway for the APRE treated cells. In presence of a @entity4 siRNA and a pan-caspase inhibitor, APRE could not reduce the viability of NB cells to a significant degree. So we predicted that with APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved. These findings demonstrate that an intrinsic mitochondria-mediated apoptosis pathway mediates the apoptotic effects of APRE on SHSY5Y cells, and that APRE shows promise as a novel agent for @entity3 therapy.

title: Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y XXXX Cells by Regulating an Intrinsic Caspase Pathway.

answer: @entity3


abstract: OBJECTIVE: To compare physiological and biochemical responses in stable preterm neonates and their parents following kangaroo mother care (KMC) and kangaroo father care (KFC). STUDY DESIGN: We conducted a prospective cross-over design study of stable preterm neonates of <35 weeks gestation in a tertiary Neonatal Unit in Toronto. All neonates received KMC and KFC for 1   h on consecutive days in a random order. Heart rate, temperature, blood pressure, @entity1 saturation and salivary @entity2 in @entity0 before and after kangaroo care and heart rate, temperature and salivary @entity2 in parents before and after kangaroo care were measured. Pairwise comparisons of changes in these measures were analyzed. RESULT: Twenty-six sets of neonates and their parents were studied for physiological parameters, of which 19 had adequate samples for salivary @entity2 assessment. The @entity0 had a mean birth weight of 1096   g (s.d.=217) and a mean postmenstrual age at study of 32 weeks (s.d.=2). There were no significant differences in the changes in mean heart rate (P=0.51), temperature (P=0.37), @entity1 saturation (P=0.50), systolic blood pressure (P=0.32), mean blood pressure (0.10) and salivary @entity2 (P=0.50) before and after KMC or KFC in the neonates. The changes in mean heart rate (P=0.62), temperature (P=0.28) and salivary @entity2 (P=0.59) before and after kangaroo care were similar between mothers and fathers. CONCLUSION: No significant differences in physiological and stress responses were identified following KMC or KFC in preterm neonates. KFC may be as safe and as effective as KMC.Journal of Perinatology advance online publication, 17 December 2015; doi:10.1038/jp.2015.196.

title: Kangaroo care by fathers and mothers: comparison of physiological and stress responses in preterm XXXX .

answer: @entity0


abstract: SCOPE: The 9cis,11trans-conjugated @entity6 (9c,11t- @entity5 ) is reported to have anti-atherogenic properties in animal models and to modulate protein expression in unstimulated @entity0 platelets in vivo. Platelet function was therefore investigated after dietary supplementation with 9c,11t- @entity5 enriched oil (CLA80:20) in a randomized, baseline-controlled cross-over trial. METHODS AND RESULTS: Forty-three healthy adults at low to moderate risk of @entity2 received 4 g/day of CLA80:20 or placebo for two weeks each. Platelet function, @entity1 , and endothelial activation were assessed before and after each phase. Compared with placebo, supplementation had no significant effects on platelet function measured by Platelet Function Analyzer-100. Inhibitory effects on collagen-induced aggregation were sex-dependent (p  =  0.005) that reached significance only in @entity0 (p  =  0.045). @entity4 ( @entity4 )-induced @entity7 expression was higher after supplementation in all subjects (p  =  0.017). @entity4 -induced platelet fibrinogen binding was also dependent on sex (p = 0.015), with fibrinogen binding after CLA80:20 being higher in males (p  =  0.035). Plasma @entity3 was higher (p  =  0.041) after CLA80:20. CONCLUSION: No clear evidence was found for inhibition or activation of platelet function as well as @entity1 by CLA80:20 in a low to moderate cardiovascular risk group.

title: Supplementation with a 9c,11t-rich conjugated XXXX blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial.

answer: @entity6


abstract: UNASSIGNED: An investigation was carried out into the genetic mechanisms responsible for multidrug resistance in nine @entity1 -resistant @entity0 aeruginosaisolates from different hospitals in Recife, Brazil. Susceptibility to antimicrobial agents was determined by broth microdilution. Polymerase chain reaction (PCR) was employed to detect the presence of genes encoding b-lactamases, @entity4 -modifying enzymes (AMEs), 16S rRNA methylases, integron-related genes and OprD. Expression of genes coding for efflux pumps and AmpC cephalosporinase were assessed by quantitative PCR. The outer membrane proteins were separated by @entity3 - @entity2 gel electrophoresis. The blaSPM-1, @entity5 and blaGES-1 genes were detected in P. aeruginosaisolates in addition to different AME genes. The loss of OprD in nine isolates was mainly due to frameshift mutations, premature stop codons and point mutations. An association of loss of OprD with the overexpression of MexAB-OprM and MexXY-OprM was observed in most isolates. Hyper-production of AmpC was also observed in three isolates. Clonal relationship of the isolates was determined by repetitive element palindromic-PCR and multilocus sequence typing. Our results show that the loss of OprD along with overexpression of efflux pumps and b-lactamase production were responsible for the multidrug resistance in the isolates analysed.

title: Mutational and acquired @entity1 resistance mechanisms in multidrug resistant XXXX clinical isolates from Recife, Brazil.

answer: @entity0


abstract: UNASSIGNED: An investigation was carried out into the genetic mechanisms responsible for multidrug resistance in nine @entity1 -resistant @entity0 aeruginosaisolates from different hospitals in Recife, Brazil. Susceptibility to antimicrobial agents was determined by broth microdilution. Polymerase chain reaction (PCR) was employed to detect the presence of genes encoding b-lactamases, @entity4 -modifying enzymes (AMEs), 16S rRNA methylases, integron-related genes and OprD. Expression of genes coding for efflux pumps and AmpC cephalosporinase were assessed by quantitative PCR. The outer membrane proteins were separated by @entity3 - @entity2 gel electrophoresis. The blaSPM-1, @entity5 and blaGES-1 genes were detected in P. aeruginosaisolates in addition to different AME genes. The loss of OprD in nine isolates was mainly due to frameshift mutations, premature stop codons and point mutations. An association of loss of OprD with the overexpression of MexAB-OprM and MexXY-OprM was observed in most isolates. Hyper-production of AmpC was also observed in three isolates. Clonal relationship of the isolates was determined by repetitive element palindromic-PCR and multilocus sequence typing. Our results show that the loss of OprD along with overexpression of efflux pumps and b-lactamase production were responsible for the multidrug resistance in the isolates analysed.

title: Mutational and acquired XXXX resistance mechanisms in multidrug resistant @entity0 clinical isolates from Recife, Brazil.

answer: @entity1


abstract: Importance: @entity5 ( @entity5 ) is a rare @entity2 , and the prognostic factors associated with long-term outcomes after surgical resection remain poorly defined. Objectives: To define clinicopathological variables associated with @entity4 ( @entity4 ) and @entity4 ( @entity4 ) after curative surgical resection of @entity5 and to propose nomograms for individual risk prediction. Design, Setting, and @entity0 : Nomograms to predict @entity4 and @entity4 after surgical resection of @entity5 were proposed using a multi-institutional cohort of @entity0 who underwent curative-intent surgery for @entity5 at 13 major institutions in the United States between March 17, 1994, and December 22, 2014. The dates of our study analysis were April 15, 2015, to May 12, 2015. Main Outcomes and Measures: The discriminative ability and calibration of the nomograms to predict @entity4 and @entity4 were tested using C statistics, calibration plots, and Kaplan-Meier curves. Results: In total, 148 @entity0 who underwent surgery for @entity5 were included in the study. The median @entity0 age was 53 years, and 65.5% (97 of 148) of the @entity0 were female. One-third of the @entity0 (35.1% [52 of 148]) had a functional @entity1 , and the median @entity1 size was 11.2 cm. Most @entity0 (77.7% [115 of 148]) underwent R0 resection, and 8.8% (13 of 148) of the @entity0 had N1 disease. Using backward stepwise selection of clinically important variables with the Akaike information criterion, the following variables were incorporated in the prediction of @entity4 : @entity1 size of at least 12 cm (hazard ratio [HR], 3.00; 95% CI, 1.63-5.70; P   <   .001), positive nodal status (HR, 4.78; 95% CI, 1.47-15.50; P   =   .01), stage III/IV (HR, 1.80; 95% CI, 0.95-3.39; P   =   .07), @entity3 -secreting @entity1 (HR, 2.38; 95% CI, 1.27-4.48; P   =   .01), and capsular invasion (HR, 1.96; 95% CI, 1.02-3.74; P   =   .04). Factors selected as predicting @entity4 were @entity1 size of at least 12 cm (HR, 1.78; 95% CI, 1.00-3.17; P   =   .05), positive nodal status (HR, 5.89; 95% CI, 2.05-16.87; P   =   .001), and R1 margin (HR, 2.83; 95% CI, 1.51-5.30; P   =   .001). The discriminative ability and calibration of the nomograms revealed good predictive ability as indicated by the C statistics (0.74 for @entity4 and 0.70 for @entity4 ). Conclusions and Relevance: Independent predictors of survival and recurrence risk after curative-intent surgery for @entity5 were selected to create nomograms predicting @entity4 and @entity4 . The nomograms were able to stratify @entity0 into prognostic groups and performed well on internal validation.

title: Nomograms to Predict Recurrence-Free and Overall Survival After Curative Resection of XXXX .

answer: @entity5


abstract: Background We report a case of @entity5 caused by consuming a Chinese herb contaminated with thyroid hormones. Case Report A 70-year-old @entity0 presented to an emergency department after 2 days of @entity1 , @entity2 , and @entity3 . Three days previously, he had started taking Cordyceps powder and "Flower @entity0 Sang Hung" as recommended by his Chinese physician. Following admission, the @entity0 deteriorated and was eventually diagnosed with @entity5 complicated by rapid @entity4 requiring cardioversion, intubation, and intensive care admission. The analysis of the Chinese herb "Flower @entity0 Sang Hung" was positive for levothyroxine. The @entity0 was extubated 11 days after admission and discharged to a rehabilitation centre after 17 days of hospitalization. The Chinese medicine physician was informed of the events. Conclusions Herbal products can be the source of illness, medication interactions, and contamination. Awareness should be raised among Chinese medicine physicians, allopathic physicians, and their @entity0 . Clinicians should also have a low threshold of suspicion to seek laboratory analysis of suspect substances when the cause of the clinical presentation is unclear.

title: XXXX caused by a chinese herb contaminated with thyroid hormones.

answer: @entity5


abstract: PURPOSE: Secukinumab, a fully human anti- @entity3 monoclonal antibody, exhibited promising activity in a proof-of-concept study when administered in intravenous (IV) doses to @entity0 with active, chronic, noninfectious @entity2 . This study compared the efficacy and safety of different IV and subcutaneous (SC) doses of secukinumab in @entity0 with noninfectious @entity2 . DESIGN: Multicenter, randomized, double-masked, dose-ranging, phase 2 clinical trial. @entity0 : Thirty-seven @entity0 with active noninfectious intermediate @entity2 , posterior @entity2 , or @entity4 who required corticosteroid-sparing immunosuppressive therapy. METHODS: @entity0 were randomized to secukinumab 300 mg SC every 2 weeks for 4 doses, secukinumab 10 mg/kg IV every 2 weeks for 4 doses, or secukinumab 30 mg/kg IV every 4 weeks for 2 doses. Intravenous or SC saline was administered to maintain masking. Efficacy was assessed on day 57 (2-4 weeks after last dose). MAIN OUTCOME MEASURES: Percentage of @entity0 with treatment response, defined as (1) at least a 2-grade reduction in vitreous haze score or trace or absent vitreous haze in the study eye without an increase in @entity1 dose and without @entity2 worsening or (2) reduction in corticosteroid dosages to prespecified levels without @entity2 worsening. Percentage of @entity0 with remission, defined as anterior chamber cell and vitreous haze scores of 0 or 0.5+ in both eyes without corticosteroid therapy or @entity2 worsening. RESULTS: Secukinumab 30 mg/kg IV and 10 mg/kg IV, compared with the 300 mg SC dose, produced higher responder rates (72.7% and 61.5% vs. 33.3%, respectively) and remission rates (27.3% and 38.5% vs. 16.7%, respectively). Statistical and clinical superiority for the 30 mg/kg IV dose compared with the 300 mg SC dose was established in a Bayesian probability model. Other measures, including time to response onset, change in visual acuity, and change in vitreous haze score, showed numeric trends favoring IV dosing. Secukinumab, administered in IV or SC formulations, appeared safe and was well tolerated. CONCLUSIONS: Intravenous secukinumab was effective and well tolerated in noninfectious @entity2 requiring systemic corticosteroid-sparing immunosuppressive therapy. Greater activity with IV dosing suggests that @entity0 may not receive sufficient drug with SC administration. High-dose IV secukinumab may be necessary to deliver secukinumab in therapeutic concentrations.

title: Efficacy and safety of intravenous secukinumab in noninfectious XXXX requiring steroid-sparing immunosuppressive therapy.

answer: @entity2


abstract: UNASSIGNED: Ultrasonic vocalizations (USVs) of 50kHz are thought to indicate positive affective states in @entity0 , and are increasingly being used to investigate the motivational properties of drugs of abuse. However, previous studies have observed that only dopaminergic psychostimulants of abuse, but not other addictive drugs, stimulate 50-kHz USVs immediately after their administration. This would suggest that 50-kHz USVs induced by addictive dopaminergic psychostimulants might reflect rewarding dopaminergic effect, rather than motivational effect. To elucidate this issue, our study compared the effects of the psychostimulant of abuse @entity3 and the @entity1 receptor agonist @entity2 on 50-kHz USVs. @entity0 that received five drug administrations on alternate days in a novel test-cage were first re-exposed to the test-cage 7 days after treatment discontinuation to assess drug-conditioning, and then received a drug challenge. USVs were recorded throughout the experiments together with locomotor activity. To further clarify how @entity3 and @entity2 influenced 50-kHz USVs, @entity0 were subdivided into "low" and "high" vocalizers, and time-dependence of drug effects was assessed. @entity3 and @entity2 stimulated both 50-kHz USVs and locomotor activity, though they elicited dissimilar changes in these behaviors, depending on drug dose, @entity0 *  individual predisposition to vocalize, and time. Moreover, only @entity3 -treated @entity0 displayed both sensitized 50-kHz USVs emission and conditioned vocalizations on test-cage re-exposure. These results indicate that the effects of @entity3 on 50-kHz USVs are not mimicked by a dopaminergic agonist with a low abuse potential, and may further support the usefulness of 50-kHz USVs in the study of the motivational properties of psychoactive drugs.

title: Repeated XXXX administration and long-term effects on 50-kHz ultrasonic vocalizations: Possible relevance to the motivational and @entity1 -stimulating properties of the drug.

answer: @entity3


abstract: UNASSIGNED: Ultrasonic vocalizations (USVs) of 50kHz are thought to indicate positive affective states in @entity0 , and are increasingly being used to investigate the motivational properties of drugs of abuse. However, previous studies have observed that only dopaminergic psychostimulants of abuse, but not other addictive drugs, stimulate 50-kHz USVs immediately after their administration. This would suggest that 50-kHz USVs induced by addictive dopaminergic psychostimulants might reflect rewarding dopaminergic effect, rather than motivational effect. To elucidate this issue, our study compared the effects of the psychostimulant of abuse @entity3 and the @entity1 receptor agonist @entity2 on 50-kHz USVs. @entity0 that received five drug administrations on alternate days in a novel test-cage were first re-exposed to the test-cage 7 days after treatment discontinuation to assess drug-conditioning, and then received a drug challenge. USVs were recorded throughout the experiments together with locomotor activity. To further clarify how @entity3 and @entity2 influenced 50-kHz USVs, @entity0 were subdivided into "low" and "high" vocalizers, and time-dependence of drug effects was assessed. @entity3 and @entity2 stimulated both 50-kHz USVs and locomotor activity, though they elicited dissimilar changes in these behaviors, depending on drug dose, @entity0 *  individual predisposition to vocalize, and time. Moreover, only @entity3 -treated @entity0 displayed both sensitized 50-kHz USVs emission and conditioned vocalizations on test-cage re-exposure. These results indicate that the effects of @entity3 on 50-kHz USVs are not mimicked by a dopaminergic agonist with a low abuse potential, and may further support the usefulness of 50-kHz USVs in the study of the motivational properties of psychoactive drugs.

title: Repeated @entity3 administration and long-term effects on 50-kHz ultrasonic vocalizations: Possible relevance to the motivational and XXXX -stimulating properties of the drug.

answer: @entity1


abstract: The reproductive and sexual health of adolescents is an important health concern and a focus of global attention. In @entity1 Lanka, a lack of understanding about adolescent reproductive and sexual health needs is a matter of national concern. A survey was undertaken to examine the sexual knowledge, attitudes and behaviours of school going adolescents in @entity1 Lanka. A random sample of schools was selected from one district. Data were collected by a self-completion questionnaire and analysed using SPSS. Response rate was 90%. 2020 pupils (26% @entity0 , 74% @entity0 ) aged 16-19 years (mean   =   16.9) participated, the majority Sinhalese (97%). Most reported a good parent- @entity0 relationship (88%). A minority (34%) discussed sexual issues with parents. Health professionals were the preferred source of sexual information (32%) rather than parents (12.5%) or friends (5.6%). Less than 1% demonstrated satisfactory sexual and reproductive knowledge levels. 1.7% were sexually active (30 @entity0 vs 5 @entity0 ), the majority with same age partners. 57% used contraception at first intercourse. There is an imperative to address the lack of sexual and reproductive knowledge. A minority of school going adolescents become sexually active. These individuals are potentially vulnerable and services need to be developed to meet their needs.

title: Sexual and reproductive knowledge, attitudes and behaviours in a school going population of XXXX Lankan adolescents.

answer: @entity1


abstract: UNASSIGNED: Effective evaluation of treatment requires the use of measurement tools producing reliable scores that can be used to make valid decisions about the outcomes of interest. Therapist-rated treatment outcome scores that are obtained within the context of empirically supported treatments (ESTs) could provide clinicians and researchers with data that are easily accessible and complimentary to existing instrumentation. We examined the psychometric properties of scores from the Therapist Perception of Treatment Outcome: Youth @entity1 (TPTO:YAB), an instrument developed to assess therapist judgments of treatment success among families participating in an EST, @entity0 ( @entity0 ), for youth with @entity1 . Data were drawn from a longitudinal study of @entity0 . The initial 20-item TPTO:YAB was completed by therapists of 111 families at midtreatment and 163 families at treatment termination. Rasch model dimensionality analyses provided evidence for 2 dimensions reflecting youth- and caregiver-related aspects of treatment outcome, although a bifactor analyses suggested that these dimensions reflected a single more general construct. Rasch analyses were also used to assess item and rating scale characteristics and refine the number of items. These analyses suggested items performed similarly across time and that scores reflect treatment outcome in similar ways at mid and posttreatment. Multilevel and zero-order analyses provided evidence for the validity of TPTO:YAB scores. TPTO:YAB scores were moderately correlated with scores of youth and @entity1 targeted in treatment, adding support to its use as a treatment outcome measurement instrument. (PsycINFO Database Record

title: Therapist perception of treatment outcome: Evaluating treatment outcomes among youth with XXXX .

answer: @entity1


abstract: BACKGROUND: Knowledge of the natural history of @entity3 ), in particular the role of immunity, is crucial in estimating the (cost-) effectiveness of @entity1 screening strategies, because naturally acquired immunity after clearing an @entity2 may already protect part of the risk population against new @entity4 . METHODS: We used STDSIM, an established stochastic microsimulation model, quantified to the Netherlands. We explored different assumptions regarding the natural history of @entity5 and HPV-18, and estimated the transmission probabilities and durations of acquired immunity necessary to reproduce age-specific prevalence. RESULTS: A model without acquired immunity cannot reproduce the age-specific patterns of HPV. Also, it is necessary to assume a high degree of individual variation in the duration of @entity2 and acquired immunity. According to the model estimates, on average 20% of @entity0 are immune for @entity5 and 15% for HPV-18. After an @entity5 @entity2 , 50% are immune for less than 1 year, whereas 20% exceed 30 years. For HPV-18, up to 12% of the individuals are immune for less than 1 year, and about 50% over 30 years. Almost half of all @entity0 will never acquire @entity5 or HPV-18. CONCLUSIONS: Acquired immunity likely plays a major role in HPV epidemiology, but its duration shows substantial variation. Combined with the lifetime risk, this explains to a large extent why many @entity0 will never develop @entity1 .

title: The Role of Acquired Immunity in the Spread of XXXX ): Explorations with a Microsimulation Model.

answer: @entity3


abstract: BACKGROUND: @entity3 ( @entity3 ) is one potential treatment option for @entity0 starting dialysis after graft loss (DAGL). However, the infectious outcomes and their associations with @entity4 use remain undetermined in these @entity0 . METHODS: A total of 41 DAGL @entity0 undergoing @entity3 were recruited. The @entity0 were divided into low- and high-dose @entity4 groups according to the median level. Additionally, they were categorized into tapering and nontapering groups, for which the tapering regimen was defined as the withdrawal of @entity2 within 1 year after starting @entity3 . Primary outcomes, such as @entity3 and exit site infection (ESI), were compared between DAGL and 712 @entity1 ( @entity1 ) @entity0 . RESULTS: The overall risk of @entity3 was similar between the @entity1 and DAGL groups. However, when the DAGL group was stratified by the @entity4 variable, the risk was higher in the high-dose or nontapering @entity4 groups than in the @entity1 or counterpart @entity4 groups. The DAGL group had a higher risk of ESI than the @entity1 group, irrespective of @entity4 dose. When the analysis was stratified by tapering regimen, the difference in ESI risks was seen only in the nontapering group and the @entity1 group; the tapering group had a similar risk of ESI as that of the @entity1 group. CONCLUSIONS: The present study first addresses the risks of @entity3 and ESI together and then raises awareness of the high risk that should be considered after using high-dose @entity2 or the nontapering regimen in the DAGL @entity0 .

title: @entity4 Use and Infectious Complication in Peritoneal Dialysis After XXXX .

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity3 ) is one potential treatment option for @entity0 starting dialysis after graft loss (DAGL). However, the infectious outcomes and their associations with @entity4 use remain undetermined in these @entity0 . METHODS: A total of 41 DAGL @entity0 undergoing @entity3 were recruited. The @entity0 were divided into low- and high-dose @entity4 groups according to the median level. Additionally, they were categorized into tapering and nontapering groups, for which the tapering regimen was defined as the withdrawal of @entity2 within 1 year after starting @entity3 . Primary outcomes, such as @entity3 and exit site infection (ESI), were compared between DAGL and 712 @entity1 ( @entity1 ) @entity0 . RESULTS: The overall risk of @entity3 was similar between the @entity1 and DAGL groups. However, when the DAGL group was stratified by the @entity4 variable, the risk was higher in the high-dose or nontapering @entity4 groups than in the @entity1 or counterpart @entity4 groups. The DAGL group had a higher risk of ESI than the @entity1 group, irrespective of @entity4 dose. When the analysis was stratified by tapering regimen, the difference in ESI risks was seen only in the nontapering group and the @entity1 group; the tapering group had a similar risk of ESI as that of the @entity1 group. CONCLUSIONS: The present study first addresses the risks of @entity3 and ESI together and then raises awareness of the high risk that should be considered after using high-dose @entity2 or the nontapering regimen in the DAGL @entity0 .

title: XXXX Use and Infectious Complication in Peritoneal Dialysis After @entity1 .

answer: @entity4


abstract: The first decade of the 20th century witnessed a surge in the incidence of @entity2 due to several highly antimicrobial-resistant bacteria in hospitals worldwide. @entity4 is one such organism that turned from an occasional respiratory pathogen into a major nosocomial pathogen. An increasing number of A. baumannii genome sequences have broadened our understanding of the genetic makeup of these bacteria and highlighted the extent of horizontal transfer of DNA. Animal models of disease combined with bacterial mutagenesis have provided some valuable insights into mechanisms of A. baumannii pathogenesis. Bacterial factors known to be important for disease include outer membrane porins, surface structures including capsule and lipopolysaccharide, enzymes such as phospholipase D, @entity1 acquisition systems, and regulatory proteins. A. baumannii has a propensity to accumulate resistance to various groups of antimicrobial agents. In particular, @entity3 resistance has become commonplace, accounting for the majority of A. baumannii strains in many hospitals today. @entity3 -resistant strains are often resistant to all other routinely tested agents. Treatment of @entity3 -resistant A. baumannii @entity2 therefore involves the use of combinations of last resort agents such as @entity5 and @entity6 , but the efficacy and safety of these approaches are yet to be defined. Antimicrobial-resistant A. baumannii has high potential to spread among ill @entity0 in intensive care units. Early recognition and timely implementation of appropriate @entity2 control measures is crucial in preventing outbreaks.

title: XXXX : evolution of antimicrobial resistance-treatment options.

answer: @entity4


abstract: We set out to describe combat-related spine @entity1 over a 10-year period, and thereby determine the frequency of new onset @entity2 secondary to injuries sustained in support of combat operations. We performed a retrospective analysis of a surgical database at three military institutions. @entity0 undergoing spine surgery following a combat-related injury in Afghanistan or Iraq between July 2003 and July 2013 were evaluated. We identified 105 @entity0 with combat-related (Operations Enduring and Iraqi Freedom) spine @entity1 requiring operative intervention. Of these, 15 (14.3%) @entity0 had @entity2 as their primary complaint after injury. All @entity0 were diagnosed with herniated nucleus pulposus. The average age was 39 years, with 80% injured in Iraq and 20% in Afghanistan. The most common mechanism of injury was mounted improvised explosive device (33%). The cervical spine was most commonly involved (53%), followed by lumbar spine (40%). Average time from injury to surgery was 23.4 months; 53% of @entity0 had continued symptoms following surgery, and two @entity0 had at least one revision surgery. Two @entity0 were medically retired because of their symptoms. This study is the only of its kind evaluating the operative treatment of @entity2 following combat-related @entity1 . We identified a relatively high rate of @entity2 in these @entity0 .

title: Operative treatment of new onset XXXX secondary to combat injury.

answer: @entity2


abstract: UNASSIGNED: @entity6 encodes the mitochondrial tyrosyl-tRNA synthetase that catalyzes the covalent binding of @entity3 to its cognate mt-tRNA. Mutations in @entity6 have been identified in @entity0 with @entity1 , @entity4 , and @entity2 (MLASA2). We report here on two siblings with a novel mutation and a review of literature. The older @entity0 presented at 2  months with marked @entity2 and @entity5 . He required periodic blood transfusions until 14 months of age. Cognitive and motor development was normal. His younger sister was diagnosed at birth, presenting with @entity2 and @entity4 at 1 month of age requiring periodical transfusions. She is now 14 months old and doing well. For both our @entity0 , there was no clinical evidence of muscle involvement. We found a new homozygous mutation in @entity6 , located in the a-anticodon-binding (aACB) domain, involved in the interaction with the anticodon of the cognate mt-tRNA(Tyr).Our study confirms that MLASA must be considered in @entity0 with @entity2 and underlines the importance of early diagnosis and supportive therapy in order to prevent severe complications. Clinical severity is variable among @entity6 -reported @entity0 : our review of the literature suggests a possible phenotype-genotype correlation, although this should be confirmed in a larger population.

title: A Novel Homozygous XXXX Mutation in Two Italian Siblings and a Review of Literature.

answer: @entity6


abstract: UNASSIGNED: @entity11 ( @entity11 ) is a rare cause of @entity6 ( @entity6 ), @entity8 and @entity5 that typically affects young @entity0 in the postpartum period. Rarely, it can be caused by systemic inflammatory conditions such as @entity3 . @entity3 is an inflammatory disease most often affecting the lung and lymph nodes that can sometimes affect the heart. The authors report a case of @entity5 caused by @entity11 in the context of undiagnosed and subclinical @entity2 . The decedent was a 47-year-old male with a relatively innocuous past medical history. He was found dead in bed. At autopsy, there was a @entity9 resulting in @entity8 . Gross examination of the heart revealed dissection of the posterior descending coronary branch of the right coronary artery. Histologically, the coronary artery showed acute and organizing dissection with evidence of @entity7 . A chronic inflammatory infiltrate consisting of lymphocytes, histiocytes, eosinophils and giant cells was seen. Sections of the myocardium showed @entity10 with a nonnecrotizing @entity4 . The @entity1 was attributed to @entity8 secondary to @entity11 in the context of systemic @entity3 . The presented case demonstrates two concurrent rare pathologies and highlights the importance of considering @entity11 in cases of @entity5 at autopsy.

title: @entity5 due to coronary artery dissection as a complication of XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity11 ( @entity11 ) is a rare cause of @entity6 ( @entity6 ), @entity8 and @entity5 that typically affects young @entity0 in the postpartum period. Rarely, it can be caused by systemic inflammatory conditions such as @entity3 . @entity3 is an inflammatory disease most often affecting the lung and lymph nodes that can sometimes affect the heart. The authors report a case of @entity5 caused by @entity11 in the context of undiagnosed and subclinical @entity2 . The decedent was a 47-year-old male with a relatively innocuous past medical history. He was found dead in bed. At autopsy, there was a @entity9 resulting in @entity8 . Gross examination of the heart revealed dissection of the posterior descending coronary branch of the right coronary artery. Histologically, the coronary artery showed acute and organizing dissection with evidence of @entity7 . A chronic inflammatory infiltrate consisting of lymphocytes, histiocytes, eosinophils and giant cells was seen. Sections of the myocardium showed @entity10 with a nonnecrotizing @entity4 . The @entity1 was attributed to @entity8 secondary to @entity11 in the context of systemic @entity3 . The presented case demonstrates two concurrent rare pathologies and highlights the importance of considering @entity11 in cases of @entity5 at autopsy.

title: XXXX due to coronary artery dissection as a complication of @entity2 .

answer: @entity5


abstract: OBJECTIVE: @entity3 in endometrioid @entity2 is uncommon, and systematic para-aortic lymph node dissection increases morbidity. The purpose of this study was to identify a subgroup of endometrioid @entity2 @entity0 who did not require para-aortic lymphadenectomy. STUDY DESIGN: All @entity0 who had undergone surgery for endometrioid @entity2 between 1 January 1995 and 31 December 2012 were retrospectively reviewed. @entity0 with higher risk factors for nodal @entity1 and inadequate lymphadenectomy were excluded. @entity3 was defined as nodal @entity1 when pelvic and para-aortic lymph node dissection was performed, when para-aortic lymph node recurrence occurred after negative para-aortic lymph node dissection or when para-aortic lymph node dissection was not performed. Multivariate logistic regression models were used to identify the pathological features as predictors for @entity4 . RESULTS: A total of 827 @entity0 were assessed, 516 (62.4%) of whom underwent pelvic and para-aortic lymph node dissection. Sixty-seven (13%) @entity0 (37 with only pelvic, 26 with pelvic and para-aortic, and 4 with only para-aortic @entity1 ) had positive lymph nodes in the pelvic and para-aortic lymph node dissection group. Multivariate analysis confirmed positive pelvic nodes (odds ratio 20.58; p<0.001) and lymphovascular space invasion (odds ratio 8.10; p=0.022) as independent predictors of @entity4 . When these two factors were absent (in 83% of @entity0 ), the predicted probability of para-aortic lymph node @entity1 was 0.1%. CONCLUSION: Positive pelvic nodes and lymphovascular space invasion are highly associated with para-aortic lymph node @entity1 . These markers may be useful for identifying those @entity0 who require para-aortic lymph node dissection.

title: Lymphovascular space invasion and positive pelvic lymph nodes are independent risk factors for para-aortic nodal XXXX in endometrioid @entity2 .

answer: @entity1


abstract: OBJECTIVE: @entity3 in endometrioid @entity2 is uncommon, and systematic para-aortic lymph node dissection increases morbidity. The purpose of this study was to identify a subgroup of endometrioid @entity2 @entity0 who did not require para-aortic lymphadenectomy. STUDY DESIGN: All @entity0 who had undergone surgery for endometrioid @entity2 between 1 January 1995 and 31 December 2012 were retrospectively reviewed. @entity0 with higher risk factors for nodal @entity1 and inadequate lymphadenectomy were excluded. @entity3 was defined as nodal @entity1 when pelvic and para-aortic lymph node dissection was performed, when para-aortic lymph node recurrence occurred after negative para-aortic lymph node dissection or when para-aortic lymph node dissection was not performed. Multivariate logistic regression models were used to identify the pathological features as predictors for @entity4 . RESULTS: A total of 827 @entity0 were assessed, 516 (62.4%) of whom underwent pelvic and para-aortic lymph node dissection. Sixty-seven (13%) @entity0 (37 with only pelvic, 26 with pelvic and para-aortic, and 4 with only para-aortic @entity1 ) had positive lymph nodes in the pelvic and para-aortic lymph node dissection group. Multivariate analysis confirmed positive pelvic nodes (odds ratio 20.58; p<0.001) and lymphovascular space invasion (odds ratio 8.10; p=0.022) as independent predictors of @entity4 . When these two factors were absent (in 83% of @entity0 ), the predicted probability of para-aortic lymph node @entity1 was 0.1%. CONCLUSION: Positive pelvic nodes and lymphovascular space invasion are highly associated with para-aortic lymph node @entity1 . These markers may be useful for identifying those @entity0 who require para-aortic lymph node dissection.

title: Lymphovascular space invasion and positive pelvic lymph nodes are independent risk factors for para-aortic nodal @entity1 in endometrioid XXXX .

answer: @entity2


abstract: Venous and interstitial fluid pressure, protein content of blood plasma, leg lymph and interstitial fluid were estimated in anaesthetized normal @entity2 and @entity1 as well as in @entity2 with chronic inferior v. cava constriction. In the tissue fluid collected by the perforated capsule and by the wick methods protein concentrations were the same. In the @entity1 hindlegs subcutaneous tissue fluid and lymph protein concentrations were 50 and 45%, respectively of plasma protein concentration. In the @entity2 tissue fluid, protein was 42.5% but lymph protein content was only 17% of plasma protein. Tissue fluid hydraulic pressure (intracapsular) was in normal @entity2 --5.0 +/- 1.3 mm Hg and it increased in cava constricted @entity2 to +0.8 +/- 0.4 mm Hg. In caval constriction, protein concentration in the interstitial fluid decreased markedly. A linear relationship was found in @entity2 and @entity1 between tissue fluid and lymph protein concentration (r = 0.68 and 0.73, respectively). The relationship between venous and tissue fluid (intracapsular) pressures was non-linear. In @entity2 hindlimbs the calculated isogravimetric capillary pressure was 7.8 mm Hg. In @entity3 both the increase of interstitial fluid hydraulic pressure, and the decrease of oncotic pressure ace as " @entity0 safety factors". In the @entity1 20 h after the intravenous injection of labelled albumin there was no significant difference between the specific radioactive albumin contents of plasma, leg lymph and tissue fluid.

title: Interstitial fluid, lymph and XXXX formation.

answer: @entity0


abstract: Psychomotor @entity4 is a widespread clinical problem both in @entity0 with @entity3 and @entity5 . It is a highly hazardous condition, imposing significant risks in @entity1 emergency, as expressedby elevated ratios of adverse events and traumatic experiences (both for @entity0 and medical staff). The available anti- @entity4 drugs have numerous disadvantages. The orally administered medications (even though preferable to: @entity0 ) take hours or even-days for the therapeutic effect to emerge .(and also there is a risk of exacerbating @entity4 in between). Although rapid onset of action (15-45 minutes) is a noteworthy merit of intramuscular drugs, such an invasive strategy is far too often bound to @entity0 ' @entity2 , resistance, and traumatic experiences. The need for novel drug formulations (ideally, both integrating the benefits of injectable and orally administered tranquillizing medications, 'and free from their disadvantages) can be, therefore, clearly grasped. Development of.inhaled @entity6 exemplifies the attempts to overcome the above-delineated obstacles. As suggested by the available research base, inhaled @entity6 seems to be an effective anti- @entity4 drug in treatment of @entity0 with schizoplhenia and @entity5 (with the onset of action similar to the one observed in intramuscular antipsychotics). However, this formulation of @entity6 is distinguished by its non-invasive route of administration, as accompanied by markedly, low risk of side effects or adverse events.

title: [Inhaled @entity6 : A novel treatment for XXXX in psychotic disorders].

answer: @entity4


abstract: Psychomotor @entity4 is a widespread clinical problem both in @entity0 with @entity3 and @entity5 . It is a highly hazardous condition, imposing significant risks in @entity1 emergency, as expressedby elevated ratios of adverse events and traumatic experiences (both for @entity0 and medical staff). The available anti- @entity4 drugs have numerous disadvantages. The orally administered medications (even though preferable to: @entity0 ) take hours or even-days for the therapeutic effect to emerge .(and also there is a risk of exacerbating @entity4 in between). Although rapid onset of action (15-45 minutes) is a noteworthy merit of intramuscular drugs, such an invasive strategy is far too often bound to @entity0 ' @entity2 , resistance, and traumatic experiences. The need for novel drug formulations (ideally, both integrating the benefits of injectable and orally administered tranquillizing medications, 'and free from their disadvantages) can be, therefore, clearly grasped. Development of.inhaled @entity6 exemplifies the attempts to overcome the above-delineated obstacles. As suggested by the available research base, inhaled @entity6 seems to be an effective anti- @entity4 drug in treatment of @entity0 with schizoplhenia and @entity5 (with the onset of action similar to the one observed in intramuscular antipsychotics). However, this formulation of @entity6 is distinguished by its non-invasive route of administration, as accompanied by markedly, low risk of side effects or adverse events.

title: [Inhaled XXXX : A novel treatment for @entity4 in psychotic disorders].

answer: @entity6


abstract: OBJECTIVES: The objective of this study was to estimate trends in incidence and relative survival ratio in @entity0 diagnosed with @entity1 in Canada over the period of 1992-2007. MATERIALS AND METHODS: We identified @entity0 with primary invasive @entity2 in the Canadian Cancer Registry (CCR) dataset. @entity0 younger than 18 years of age were excluded in this analysis. A flexible parametric model was used to estimate one- and five-year relative survival ratios and excess mortality rate. RESULTS: In total 182,417, @entity0 from CCR dataset with @entity1 were identified of which 57.2% (n=106,197) were male and the mean age at diagnosis was 68.8 (SD=11.0) years. The incidence rate of @entity1 decreased in @entity0 and increased in @entity0 . Although one-year relative survival ratio slightly improved over time for both genders and most age groups, five-year relative survival decreased for most of the groups. CONCLUSIONS: Although the incidence rate of @entity1 continued to decrease in @entity0 , it is increasing in @entity0 and the gap in incidence between @entity0 and @entity0 is narrowing. The one-year relative survival ratio gradually increased for most age groups over the study period, particularly for the younger age groups. Additionally, excess mortality rate is at its peak shortly after diagnosis and for the first 6 months and thereafter gradually decreases.

title: Temporal trends in the incidence and relative survival of XXXX in Canada: A population-based study.

answer: @entity2


abstract: BACKGROUND: Randomized trials of radiation after breast-conserving surgery (BCS) for @entity3 ( @entity3 ) found substantial rates of recurrence, with half of the recurrences being invasive. Decreasing local recurrence rates for invasive @entity0 have been observed and are largely attributed to improvements in systemic therapy. In this study, we examine recurrence rates after BCS for @entity3 over 3 decades at one institution. METHODS: We retrospectively reviewed a prospectively maintained database of @entity3 @entity1 undergoing BCS from 1978 to 2010. Cox proportional hazard models were used to investigate the association between the treatment period and recurrence, controlling for other variables. RESULTS: Overall, 363 (12  %) recurrences among 2996 cases were observed. Median follow-up for @entity1 without recurrence was 75  months (range 0-30  years); 732 @entity1 were followed for >= 10  years. The 5-year recurrence rate for the period 1978-1998 was 13.6 versus 6.6  % for the period 1999-2010 [hazard ratio (HR) 0.62, p  <  0.0001]. Controlling for age, family history, presentation, nuclear grade, @entity2 , number of excisions, margin status, radiation, and endocrine therapy, treatment period remained significantly associated with recurrence, with later years associated with a lower HR (0.74, p  =  0.02) compared to earlier. After stratification by radiation use, association of recurrence with treatment period persisted in those treated without radiation (HR 0.62, p  =  0.003). CONCLUSIONS: Recurrence rates for @entity3 have fallen over time, with increases in screen detection, negative margins, and use of adjuvant therapies only partially explaining this decrease. The unexplained decline persists in @entity1 not receiving radiation, suggesting it is not due to changes in radiation efficacy but may be due to improvements in radiologic detection and pathologic assessment.

title: Decreasing Recurrence Rates for Ductal Carcinoma In Situ: Analysis of 2996 XXXX Treated with Breast-Conserving Surgery Over 30 Years.

answer: @entity1


abstract: UNASSIGNED: Host-defense mechanisms may have an important role in predicting the outcome of @entity2 @entity0 . We designed our study to evaluate the possible prognostic significance of the presence of @entity4 ( @entity4 ) and subgroups of lymphocytes (CD3 and @entity3 ) in the @entity1 . We randomly selected 195 @entity0 operated for @entity2 from a larger cohort of 1527 @entity0 with @entity2 . Histological slides were blindly reevaluated for the presence of @entity4 that was graded 0 to 3. Immunohistochemical phenotyping of the lymphocytes was performed only for @entity1 with @entity4 score 3 and included antibodies CD3 and @entity3 . CD3 and @entity3 immunostaining were graded in the same manner as @entity4 . The mean duration of follow-up was 63.8 months. The distribution of @entity0 with @entity2 according to @entity4 scores was as follows: score 0, 20/195 (10.2%); score 1, 61/195 (31.3%); score 2, 78/195 (40%); and score 3, 36/195 (18.5%). There was no correlation between any clinicopathological pattern and @entity4 . Score 3 staining for CD3 was more common than for @entity3 (64.7% vs 8.8%, P < .0001). @entity4 (score 3) was associated with better disease-free survival (P = .062). Recurrence was diagnosed among 2/22 (9.1%) @entity0 with prominent CD3 staining versus 62/171 (36.2%) of all other @entity0 groups (P = .054) and they correspondingly had better disease-free survival (P = .018). It seems we can identify a group of @entity0 with @entity2 who have an excellent prognosis according to a single immunological test unrelated to other known prognostic factors.

title: Lymphocytic Infiltration as a Prognostic Factor in XXXX With Colon Cancer.

answer: @entity0


abstract: Modern adjuncts to complex, open @entity1 repair often include component separation (CS) and/or panniculectomy ( @entity2 ). This study examines nationwide data to determine how these techniques impact postoperative complications. The National Surgical Quality Improvement Program database was queried from 2005 to 2013 for inpatient, elective open @entity1 (OVHR). Cases were grouped by the need for and type of concomitant advancement flaps: OVHR alone (OVHRA), OVHR with CS, OVHR with panniculectomy ( @entity2 ), or both @entity2 (BOTH). Multivariate regression to control for confounding factors was conducted. There were 58,845 OVHR: 51,494 OVHRA, 5,357 CS, 1,617 @entity2 , and 377 BOTH. Wound complications (OVHRA 8.2%, CS 12.8%, @entity2 14.4%, BOTH 17.5%), general complications (15.2%, 24.9%, 25.2%, 31.6%), and major complications (6.9%, 11.4%, 7.2%, 13.5%) were different between groups (P < 0.0001). There was no difference in mortality. Multivariate regression showed CS had higher odds of wound [odds ratio (OR) 1.7, 95% confidence interval (CI) 1.5-2.0], general (OR 1.5, 95% CI: 1.3-1.8), and major complications (OR 2.1, 95%, CI: 1.8-2.4), and longer length of stay by 2.3 days. @entity2 had higher odds of wound (OR 1.5, 95%, CI: 1.3-1.8) and general complications (OR 1.7, 95%CI: 1.5-2.0). Both CS and @entity2 had higher odds of wound (OR 2.2, 95%, CI: 1.5-3.2), general (OR 2.5, 95%, CI: 1.8-3.4), and major complications (OR 2.2, 95%CI: 1.4-3.4), and two days longer length of stay. In conclusion, @entity0 undergoing OVHR that require CS or @entity2 have a higher independent risk of complications, which increases when the procedures are combined.

title: National Outcomes for Open XXXX Repair Techniques in Complex Abdominal Wall Reconstruction.

answer: @entity1


abstract: The purpose of this study was to review central line-associated blood stream @entity2 (CLABSI) data from a surgical @entity1 intensive care unit to better understand @entity0 risk factors, pathogens, and treatment interventions. We performed a retrospective review of all surgical ICU @entity0 who met the Centers for Disease Control definition for Gram-negative CLABSI from 2006 through 2013. Demographics, pathogens, interventions, and outcomes were evaluated. A total of 40 @entity0 were included with an average age of 49.9    19 years and 72.5 per cent male. The average length of central venous line (CVL) was 11    5.9 days with average time from line placement to positive culture 9.4    6.8 days. Most common organisms were Enterobacter species (37.5%) with 17.8 per cent of all cultured organisms considered multidrug resistant. @entity3 - @entity4 (67.5%) was the most commonly used antibiotic. Overall mortality rate was 22.5 per cent. A total of 11 @entity0 who developed a recurrence did so at 10.7    8 days and were similar to those without recurrence. Predominant pathogens associated with surgical @entity1 intensive care unit CLABSI in this study are different from those Gram-negative bacteria associated with published studies in the general hospital population. Further investigation into risk factors for @entity2 and relapse is important to minimize such consequences. Understanding appropriate line placement and use as well as clarifying optimal duration of therapy is integral in improving outcomes.

title: Understanding Gram-negative Central Line-Associated Blood Stream Infection in a Surgical XXXX ICU.

answer: @entity1


abstract: UNASSIGNED: In July 2012, two simultaneous wildfires burnt a big area in Valencia (Spain), where a birth cohort study (INMA) is being developed. The heavy smoke covered the whole INMA study area for several days. We aimed at evaluating the 2012 Valencia wildfire effects on the health of @entity0 enrolled in the INMA-Valencia cohort. Two weeks after the extinction of the wildfires, a phone survey was conducted and finally 460 individuals were enrolled. We considered a wildfire period (12-day interval when they were active) and a control period (12-day interval just before wildfires). Parents were asked about respiratory symptoms experienced during both periods, and during wildfires only about the preventive measures adopted and the perception of exposure, along with individual data collected through the different follow-up surveys of the cohort. Conditional logistic regression models were applied, and we included interaction terms for @entity1 / @entity3 and level of perception of exposure; 82.4  % perceived smoke smell outdoors, 40  % indoors and more than 90  % of the families observed the presence of ash. An adjusted odds ratio of 3.11 [95  % confidence interval 1.62-5.97] for itchy/ @entity2 and 3.02 [1.41-6.44] for sore throat was obtained. Significant interaction terms for @entity3 and @entity1 in itchy/ @entity2 and sneezing, and only @entity1 for sore throat were obtained. Exposure to wildfire smoke was associated with increased respiratory symptoms in this @entity0 population, particularly affecting susceptible individuals with @entity1 or @entity3 .

title: Health effects of the 2012 Valencia (Spain) wildfires on XXXX in a cohort study.

answer: @entity0


abstract: UNASSIGNED: GABAA receptors (GABAARs) mediate rapid inhibitory transmission in the brain. GABAARs are ligand-gated @entity5 ion channel proteins and exist in about a dozen or more heteropentameric subtypes exhibiting variable age and brain regional localization and thus participation in differing brain functions and diseases. GABAARs are also subject to modulation by several chemotypes of allosteric ligands that help define structure and function, including subtype definition. The channel blocker @entity8 identified a noncompetitive channel blocker site in GABAARs. This ligand site is located in the transmembrane channel pore, whereas the @entity3 agonist site is in the extracellular domain at subunit interfaces, a site useful for low energy coupled conformational changes of the functional channel domain. Two classes of pharmacologically important allosteric modulatory ligand binding sites reside in the extracellular domain at modified agonist sites at other subunit interfaces: the @entity2 site and the high-affinity, relevant to intoxication, @entity1 site. The @entity2 site is specific for certain GABAAR subtypes, mainly synaptic, while the @entity1 site is found at a modified @entity2 site on different, extrasynaptic, subtypes. In the transmembrane domain are allosteric modulatory ligand sites for diverse chemotypes of general anesthetics: the volatile and intravenous agents, @entity9 , @entity7 , @entity4 , long-chain @entity6 , and neurosteroids. The last are endogenous positive allosteric modulators. X-ray crystal structures of prokaryotic and invertebrate pentameric ligand-gated ion channels, and the @entity0 GABAAR protein, allow homology modeling of GABAAR subtypes with the various ligand sites located to suggest the structure and function of these proteins and their pharmacological modulation.

title: Allosteric Ligands and Their Binding Sites Define y-Aminobutyric Acid ( XXXX ) Type A Receptor Subtypes.

answer: @entity3


abstract: Total correction of underdeveloped right ventricle related to @entity1 has been performed in 6 @entity0 at the department of @entity2 and cardiovascular surgery University G  ttingen. In 5 @entity0 reconstruction of a four-chamber-four-valved heart could be accomplished. 1 @entity0 with a poor result after Fontan's operation, performed one year previously, showed a significant growth in size of the hypoplastic right ventricle in the postoperative angiogram, but died 14 hours after reoperation. Prior to corrective surgery, 4 @entity0 required 1 or 2 palliative procedures: 3 Glenn- and 2 Blalock-Taussig operations and a pulmonary valvulotomy in 1 @entity0 . A Hancock-valved conduit was inserted between the right atrium and the hypoplastic right ventricle as an inlet of this chamber after closure of the @entity4 and @entity3 in 4 @entity0 . The conduits are bypassing the hypoplastic tricuspid valve orifices closed during corrective surgery. In the remainder 2 @entity0 with moderate tricuspid and right @entity5 , closure of the @entity4 was performed only. Anomalous muscle bundles and fibrous tissue inside the right ventricular cavity were resected surgically, safely. 4 to 12 months after corrective surgery the 5 survivors were investigated by cardiac catheterization. In the 3 @entity0 operated with a valved conduit there was a moderate growth in size of the hypoplastic right ventricle, the right atrial pressure was elevated and ranged from p = 14 to 16 mm Hg. There was a slight right atrial-right ventricular gradient of 4 mm Hg across the valved conduit. The 2 @entity0 with closure of the @entity4 and @entity3 only had a nearly normal-sized right ventricle and a right atrial pressure of p = 10 mm Hg or less at the postoperative right ventricle and a right atrial pressure of p = 10 mm Hg or less at the postoperative investigation. All of them were acyanotic and had an improved or normal exercise tolerance. We concluded that reconstruction of an underdeveloped right ventricle in well-selected cases will yield more physiological benefits than do current surgical procedures, in which a conduit is interposed between the right atrium and the main pulmonary artery.

title: [Reconstruction of underdeveloped right ventricle and XXXX (author's transl)].

answer: @entity1


abstract: UNASSIGNED: @entity0 ( @entity0 ) is a blinding disease. Two important risk factors for this disease are a positive family history and @entity2 (IOP), which is also highly heritable. Genes found to date associated with IOP and @entity0 are @entity5 , @entity4 / @entity8 , @entity11 and @entity9 . However, these genes explain only a small part of the heritability of IOP and @entity0 . We performed a genome-wide association study of IOP in the population-based Rotterdam Study I and Rotterdam Study II using single nucleotide polymorphisms (SNPs) imputed to 1000 Genomes. In this discovery cohort (n = 8105), we identified a new locus associated with IOP. The most significantly associated SNP was @entity13 (b = 0.44, P-value = 1.87 * 10(-8), minor allele frequency = 0.12), within the gene @entity12 . Independent replication in five population-based studies (n = 7471) resulted in an effect size in the same direction that was significantly associated (b = 0.16, P-value = 0.04). The SNP was also significantly associated with @entity0 in two independent case-control studies [n = 1225 cases and n = 4117 controls; odds ratio (OR) = 1.53, P-value = 1.99 * 10(-8)], especially with high-tension @entity1 (OR = 1.66, P-value = 2.81 * 10(-9); for normal-tension @entity1 OR = 1.29, P-value = 4.23 * 10(-2)). @entity12 plays an important role in the @entity3 / @entity3 kinase pathway, which has been implicated in IOP regulation. Furthermore, it binds to @entity5 and links the @entity5 , @entity4 / @entity8 and @entity11 pathway to Mendelian @entity0 genes ( @entity6 , @entity7 , @entity10 ). In conclusion, this study identified a novel association between IOP and @entity12 .

title: @entity12 influences the risk of @entity1 by XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity0 ( @entity0 ) is a blinding disease. Two important risk factors for this disease are a positive family history and @entity2 (IOP), which is also highly heritable. Genes found to date associated with IOP and @entity0 are @entity5 , @entity4 / @entity8 , @entity11 and @entity9 . However, these genes explain only a small part of the heritability of IOP and @entity0 . We performed a genome-wide association study of IOP in the population-based Rotterdam Study I and Rotterdam Study II using single nucleotide polymorphisms (SNPs) imputed to 1000 Genomes. In this discovery cohort (n = 8105), we identified a new locus associated with IOP. The most significantly associated SNP was @entity13 (b = 0.44, P-value = 1.87 * 10(-8), minor allele frequency = 0.12), within the gene @entity12 . Independent replication in five population-based studies (n = 7471) resulted in an effect size in the same direction that was significantly associated (b = 0.16, P-value = 0.04). The SNP was also significantly associated with @entity0 in two independent case-control studies [n = 1225 cases and n = 4117 controls; odds ratio (OR) = 1.53, P-value = 1.99 * 10(-8)], especially with high-tension @entity1 (OR = 1.66, P-value = 2.81 * 10(-9); for normal-tension @entity1 OR = 1.29, P-value = 4.23 * 10(-2)). @entity12 plays an important role in the @entity3 / @entity3 kinase pathway, which has been implicated in IOP regulation. Furthermore, it binds to @entity5 and links the @entity5 , @entity4 / @entity8 and @entity11 pathway to Mendelian @entity0 genes ( @entity6 , @entity7 , @entity10 ). In conclusion, this study identified a novel association between IOP and @entity12 .

title: XXXX influences the risk of @entity1 by @entity2 .

answer: @entity12


abstract: UNASSIGNED: @entity0 ( @entity0 ) is a blinding disease. Two important risk factors for this disease are a positive family history and @entity2 (IOP), which is also highly heritable. Genes found to date associated with IOP and @entity0 are @entity5 , @entity4 / @entity8 , @entity11 and @entity9 . However, these genes explain only a small part of the heritability of IOP and @entity0 . We performed a genome-wide association study of IOP in the population-based Rotterdam Study I and Rotterdam Study II using single nucleotide polymorphisms (SNPs) imputed to 1000 Genomes. In this discovery cohort (n = 8105), we identified a new locus associated with IOP. The most significantly associated SNP was @entity13 (b = 0.44, P-value = 1.87 * 10(-8), minor allele frequency = 0.12), within the gene @entity12 . Independent replication in five population-based studies (n = 7471) resulted in an effect size in the same direction that was significantly associated (b = 0.16, P-value = 0.04). The SNP was also significantly associated with @entity0 in two independent case-control studies [n = 1225 cases and n = 4117 controls; odds ratio (OR) = 1.53, P-value = 1.99 * 10(-8)], especially with high-tension @entity1 (OR = 1.66, P-value = 2.81 * 10(-9); for normal-tension @entity1 OR = 1.29, P-value = 4.23 * 10(-2)). @entity12 plays an important role in the @entity3 / @entity3 kinase pathway, which has been implicated in IOP regulation. Furthermore, it binds to @entity5 and links the @entity5 , @entity4 / @entity8 and @entity11 pathway to Mendelian @entity0 genes ( @entity6 , @entity7 , @entity10 ). In conclusion, this study identified a novel association between IOP and @entity12 .

title: @entity12 influences the risk of XXXX by @entity2 .

answer: @entity1


abstract: UNASSIGNED: The primary cilium is an organelle present in most of the cells of the organism. Ciliopathies are @entity2 of the primary cilium and can be associated with @entity1 . We have studied the primary cilium during adipocyte differentiation of @entity0 adipose stem cells (hASC). We show here that the size of the primary cilium follows several modifications during adipocyte differentiation. It is absent in growing cells and appears in confluent cells. Interestingly, during the first days of differentiation, the cilium undergoes a dramatic elongation that can be mimicked by @entity3 alone. Thereafter, its size decreases. It can still be detected in cells that begin to accumulate lipids but is absent in cells that are filled with lipids. The cilium elongation does not seem to affect the localization of proteins associated with the cilium such as @entity4 or Smoothened. However, Hedgehog signaling, an anti-adipogenic pathway dependent on the primary cilium, is inhibited after three days of differentiation, concomitantly with the cilium size increase. Together, these results shed new light on the primary cilium and could provide us with new information on adipocyte differentiation under normal and pathological conditions.

title: The primary cilium undergoes dynamic size modifications during adipocyte differentiation of XXXX adipose stem cells.

answer: @entity0


abstract: STUDY OBJECTIVE: In 2008, a pay-for-performance program was implemented in sequential waves in Ontario @entity1 ( @entity1 ), with the aim of reducing length of stay. We seek to evaluate its effects on @entity2 length of stay and quality of care. METHODS: This was a retrospective observational study of @entity2 visits in Ontario from April 1, 2007, to March 31, 2011, using multivariable difference-in-differences analysis. Pay-for-performance hospitals and matched control sites were selected for each of 3 waves of the program. The primary outcome was 90th percentile @entity2 length of stay; we also examined quality-of-care indicators. RESULTS: Pay-for-performance hospitals had a modest reduction in overall adjusted 90th percentile @entity2 length of stay in @entity3 (-36 minutes; 95% confidence interval [CI] -50 to -21 minutes), but not in @entity4 (-14 minutes; 95% CI -30 to 2 minutes) or @entity5 (-7 minutes; 95% CI -23 to 8 minutes). @entity2 admitted @entity0 had a pronounced reduction in adjusted 90th percentile length of stay in @entity3 (-225 minutes; 95% CI -263 to -188 minutes) and @entity4 (-133 minutes; 95% CI -175 to -91 minutes). Nonadmitted low-acuity @entity0 had reductions in adjusted 90th percentile @entity2 length of stay in @entity3 (-24 minutes; 95% CI -29 to -18 minutes) and @entity5 (-19 minutes; 95% CI -24 to -14 minutes). The program did not negatively affect @entity2 quality-of-care measures, such as 30-day mortality or readmission rates. CONCLUSION: Pay-for-performance was associated with modest overall benefits for @entity2 length of stay without adversely affecting quality of care.

title: The Effect of Pay for Performance in the Emergency Department on XXXX Waiting Times and Quality of Care in Ontario, Canada: A Difference-in-Differences Analysis.

answer: @entity0


abstract: OBJECTIVE: Increasingly, @entity3 and @entity2 are recognized as risk factors for @entity1 . We sought to determine whether @entity0 with these diagnoses have become more likely to undergo inpatient polysomnogram (PSG) over time and to identify evolving trends in PSG utilization. METHODS: Retrospective analysis of the Kids' Inpatient Database from 2003 to 2012. @entity0 <21 years who underwent PSG were included. Weighted comparisons of clinical/demographic characteristics of @entity0 undergoing PSG were performed, as were associations between clinical and demographic @entity0 characteristics and performance of inpatient PSG. RESULTS: Between 2003 and 2012, PSG procedures decreased from 1266 to 829 (P < .001). Among @entity0 who underwent PSG, mean age decreased from 3.9    5.1 to 3.1    5.2 years (P = .001), and the frequency of age <1 year increased from 47.8% to 59.5% (P < .001). The frequency of @entity3 increased from 2.5% to 14.3% (P < .001), while the frequency of @entity2 increased from 6.2% to 19.4% (P < .001). @entity3 and @entity2 were predictive of undergoing inpatient PSG in both timeframes. CONCLUSION: Despite decreasing PSG volumes, diagnoses of @entity3 and @entity2 comprised increasing fractions of @entity0 undergoing inpatient PSG between 2003 and 2012. @entity3 and @entity2 were also predictive of inpatient PSG use in both timeframes.

title: Trends in Inpatient Pediatric Polysomnography for XXXX and @entity2 .

answer: @entity3


abstract: OBJECTIVE: Increasingly, @entity3 and @entity2 are recognized as risk factors for @entity1 . We sought to determine whether @entity0 with these diagnoses have become more likely to undergo inpatient polysomnogram (PSG) over time and to identify evolving trends in PSG utilization. METHODS: Retrospective analysis of the Kids' Inpatient Database from 2003 to 2012. @entity0 <21 years who underwent PSG were included. Weighted comparisons of clinical/demographic characteristics of @entity0 undergoing PSG were performed, as were associations between clinical and demographic @entity0 characteristics and performance of inpatient PSG. RESULTS: Between 2003 and 2012, PSG procedures decreased from 1266 to 829 (P < .001). Among @entity0 who underwent PSG, mean age decreased from 3.9    5.1 to 3.1    5.2 years (P = .001), and the frequency of age <1 year increased from 47.8% to 59.5% (P < .001). The frequency of @entity3 increased from 2.5% to 14.3% (P < .001), while the frequency of @entity2 increased from 6.2% to 19.4% (P < .001). @entity3 and @entity2 were predictive of undergoing inpatient PSG in both timeframes. CONCLUSION: Despite decreasing PSG volumes, diagnoses of @entity3 and @entity2 comprised increasing fractions of @entity0 undergoing inpatient PSG between 2003 and 2012. @entity3 and @entity2 were also predictive of inpatient PSG use in both timeframes.

title: Trends in Inpatient Pediatric Polysomnography for @entity3 and XXXX .

answer: @entity2


abstract: PURPOSE: To evaluate the role of endovascular treatment for controlling @entity4 in haemodynamically unstable @entity0 with @entity2 and to relate clinical efficacy to pre-procedural variables. MATERIALS AND METHODS: From March 2009 through April 2013, 168 @entity0 with major pelvic @entity1 associated with high-flow @entity4 were referred to our emergency department and were retrospectively reviewed. Pelvic arteries involved were one or more per @entity0 . Embolisation was performed using various materials (micro-coils, Spongostan, plug, glue, covered stent), and technical success, complications, treatment success, clinical efficacy, rebleeding, and mortality rates were assessed. Factors influencing clinical efficacy were also evaluated. RESULTS: The technical success rate was 100  %; no complications occurred during the procedures. Treatment was successful in 94.6  % cases, and clinical efficacy was 85.7  %. Three @entity0 had to undergo a second arteriography due to recurrent @entity4 . Fifteen @entity0 died. Pre-embolisation transfusion demand was significantly associated with clinical efficacy. CONCLUSIONS: Percutaneous embolisation of @entity4 may be considered a safe, effective, and minimally invasive therapeutic option. As haemodynamic stability is the first objective with traumatic @entity4 @entity0 , arterial embolisation can assume a primary role. On the basis of our results, pre-procedural transfusion status may be considered a prognostic factor. KEY POINTS:     The series presented is one of the largest in a single centre.     @entity3 is a life-saving procedure in @entity0 with @entity4 .     In pelvic @entity1 associated with @entity4 , prognosis is dependent upon prompt treatment.     Transfusion status is significantly related to clinical efficacy.

title: The role of endovascular treatment of pelvic XXXX bleeding in emergency settings.

answer: @entity2


abstract: Recent data has indicated that, besides its classical therapeutic indication in hyperurecemia and gout, @entity10 inhibitors can be used to various forms of @entity2 and other types of tissue and @entity6 . We tested the hypothesis that allopurinol, an inhibitor of @entity10 ( @entity10 ), might modulate acute and/or chronic inflammatory angiogenesis induced by subcutaneous implantation of synthetic matrix in @entity0 . C57/BL6 male @entity0 (6-7 weeks) were implanted with polyether-polyurethane sponge discs. The animals received by oral gavage 1.0mg/kg of allopurinol for six consecutive days in two treatment regimen. In the first series of experiments, the treatment was initiated 24h post-implantation and the implants were removed at day 7 post-implantation. For the assessment of the effect of the compound on @entity1 , the treatment was initiated at day 8 post-implantation and the implants removed 14days post-implantation. Angiogenesis as determined by hemoglobin content, @entity7 levels and number of vessels intraimplant, and @entity1 (myeloperoxidase -MPO, n-acetyl-b-d-glucosaminidase - @entity9 , @entity4 and @entity8 levels) were reduced by allopurinol treatment in acute phase. Similarly, the treatment inhibited nitric oxide and H2O2 production. However, fibrogenesis determined by collagen deposition and levels of @entity5 increased in the implants after allopurinol treatment. In marked contrast with the effects when the treatment initiated 24h post-implantation, allopurinol increased angiogenesis and @entity1 but reduced collagen and @entity5 levels intra-implant, when the treatment was started during the chronic inflammatory process. The dual effects of allopurinol described here, extend its range of actions as a potential agent able to modulate the components of the fibrovascular tissue present in both physiological (healing processes) as well as in chronic @entity3 . These modulatory effects depended on the phase at which the treatment was initiated.

title: Angiopreventive versus angiopromoting effects of allopurinol in the XXXX sponge model.

answer: @entity0


abstract: PURPOSE: @entity6 ( @entity6 ) is a condition of severe @entity2 or @entity3 accompanied by various complications during pregnancy. In the present study, we aimed to demonstrate the effects of @entity6 on mother and fetus health. METHODS: Control and case group were arranged from 50 healthy pregnant @entity0 and 50 pregnant @entity0 with @entity6 . Information about the @entity0 @entity0 was gathered with data collection form and Beck's @entity1 Inventory (BDI) and State Anxiety Inventory (SAI) were administered to the @entity0 . Following an abortion or delivery, the data about birth complications and neonatal health were collected. All laboratory results (blood count, thyroid hormones, electrolyte values and biochemical parameters) were gathered from the laboratory information system used in the hospital. RESULTS: It was found that in the case group, mean postpartum weight, serum hemoglobin, hematocrit and thyroid stimulant hormone levels were lower than control group (p  <  0.01). Conversely, case group @entity0 have higher T3 and T4 levels than control group (p  <  0.01). There was no significant difference between the two groups in terms of @entity5 , low birth weight and abortion but it was observed that @entity0 with @entity6 had often delivered prematurely. The mean scores of BDI and SAI in the case group were higher than those of control group. CONCLUSION: These results suggested that @entity6 may have adverse effects on both mother and baby's health. Pregnant @entity0 with @entity6 should be provided with training and consultancy services and be closely monitored in terms of @entity4 and thyroid hormones.

title: XXXX affects maternal sanity, thyroid hormones and fetal health: a prospective case control study.

answer: @entity6


abstract: BACKGROUND: The majority of @entity0 with @entity4 ( @entity4 ) who undergo complete @entity2 resection subsequently develop @entity2 recurrence. The objectives of this study were to determine the risk factors for @entity4 recurrence after curative (R0) liver resection and to identify the feasibility about postoperative adjuvant @entity3 ( @entity3 ). METHODS: We retrospectively reviewed @entity0 who underwent liver resection for @entity4 between April 1995 and December 2012 at Samsung Medical Center. Cox regression analysis was performed to determine risk factors of recurrence. @entity0 with a recurrence in remnant liver within 2  cm from the resection margin, with or without locoregional lymph node (LN) @entity1 , were considered as potential @entity3 candidates. Center-of-mass (COM) distances between the recurrent @entity2 and the cut surface were measured with MATLAB. RESULTS: We included 153 out of 198 @entity0 who underwent partial liver resection for @entity4 . About two thirds (n   =   93, 60.8  %) of @entity0 developed recurrent disease. The median recurrence-free survival (RFS) was 14  months (range, 0-204). @entity2 size >= 4.0  cm, LN @entity1 and @entity2 were significant predictors of @entity4 recurrence on multivariate analysis. @entity2 size >= 5.0  cm was the only factor associated with recurrence beyond the @entity3 field in @entity0 with recurrence. Among 93 @entity0 with recurrence, 16 (17.2  %) @entity0 were recurred in the @entity3 field. CONCLUSION: After curative resection in @entity4 , more than 60  % of @entity0 recurred, and among recurred @entity0 , 17.2  % were recurred within the @entity3 field. Consequently, for control of locoregional recurrence, adjuvant @entity3 could be carefully considered in @entity0 with recurrence factors. Especially, @entity0 with a @entity2 size larger than 5  cm should be judiciously selected for adjuvant @entity3 .

title: Predictors and patterns of recurrence after curative liver resection in XXXX , for application of postoperative radiotherapy: a retrospective study.

answer: @entity4


abstract: UNASSIGNED: Charged particle therapy is generally regarded as cutting-edge technology in oncology. Many proton therapy centres are active in the USA, Europe, and Asia, but only a few centres use heavy ions, even though these ions are much more effective than x-rays owing to the special radiobiological properties of densely ionising radiation. The National Institute of Radiological Sciences (NIRS) Chiba, Japan, has been treating @entity1 with high-energy @entity2 ions since 1994. So far, more than 8000 @entity0 have had this treatment at NIRS, and the centre thus has by far the greatest experience in @entity2 ion treatment worldwide. A panel of radiation oncologists, radiobiologists, and medical physicists from the USA and Europe recently completed peer review of the @entity2 ion therapy at NIRS. The review panel had access to the latest developments in treatment planning and beam delivery and to all updated clinical data produced at NIRS. A detailed comparison with the most advanced results obtained with x-rays or protons in Europe and the USA was then possible. In addition to those @entity1 for which @entity2 ions are known to produce excellent results, such as bone and soft-tissue sarcoma of the skull base, head and neck, and pelvis, promising data were obtained for other @entity1 , such as locally recurrent @entity1 and @entity3 . The most serious impediment to the worldwide spread of heavy ion therapy centres is the high initial capital cost. The 20 years of clinical experience at NIRS can help guide strategic decisions on the design and construction of new heavy ion therapy centres.

title: XXXX ion radiotherapy in Japan: an assessment of 20 years of clinical experience.

answer: @entity2


abstract: UNASSIGNED: Non-synonymous single @entity5 variants (nsSNVs) in coding DNA regions can result in phenotypic differences between individuals; however, only some nsSNVs are causative for a certain disease. As just a fraction of respective nsSNVs is annotated in databases, computational biology tools are applied to predict the pathogenicity in silico. In addition to applications in oncology, novel molecular diagnostic tests have been developed for @entity2 as a leading cause of morbidity and mortality in industrialized nations. We explored the concordance and performance of 13 nsSNV pathogenicity prediction tools on panel sequencing results of @entity4 . The analyzed data set from the INHERITANCE study contained 842 nsSNVs discovered in 639 @entity0 , screened for the full sequence of 76 genes related to @entity3 . The single tools prediction revealed a surprisingly high heterogeneity and discordance based on the implemented prediction method. Known disease associations were not reported by the tools, limiting usability in clinics. Because different tools have different advantages, we combined their results. By clustering of correlated methods using similar prediction strategies and calculating a majority vote-based consensus, we found that the prediction accuracy and sensitivity can be further improved. Although challenges remain, different in silico tools bear the potential to predict the @entity1 , especially if different algorithms are combined. Most tools rely mainly on sequence features; beyond these, structural information is important to analyze the relationship of nsSNVs with disease phenotypes. Likewise, current tools consider single nsSNVs, which may, however, show a cumulative effect and turn neutral mutations in an ensemble into pathogenic variants.

title: Pathogenicity prediction of non-synonymous single XXXX variants in @entity4 .

answer: @entity5


abstract: UNASSIGNED: Non-synonymous single @entity5 variants (nsSNVs) in coding DNA regions can result in phenotypic differences between individuals; however, only some nsSNVs are causative for a certain disease. As just a fraction of respective nsSNVs is annotated in databases, computational biology tools are applied to predict the pathogenicity in silico. In addition to applications in oncology, novel molecular diagnostic tests have been developed for @entity2 as a leading cause of morbidity and mortality in industrialized nations. We explored the concordance and performance of 13 nsSNV pathogenicity prediction tools on panel sequencing results of @entity4 . The analyzed data set from the INHERITANCE study contained 842 nsSNVs discovered in 639 @entity0 , screened for the full sequence of 76 genes related to @entity3 . The single tools prediction revealed a surprisingly high heterogeneity and discordance based on the implemented prediction method. Known disease associations were not reported by the tools, limiting usability in clinics. Because different tools have different advantages, we combined their results. By clustering of correlated methods using similar prediction strategies and calculating a majority vote-based consensus, we found that the prediction accuracy and sensitivity can be further improved. Although challenges remain, different in silico tools bear the potential to predict the @entity1 , especially if different algorithms are combined. Most tools rely mainly on sequence features; beyond these, structural information is important to analyze the relationship of nsSNVs with disease phenotypes. Likewise, current tools consider single nsSNVs, which may, however, show a cumulative effect and turn neutral mutations in an ensemble into pathogenic variants.

title: Pathogenicity prediction of non-synonymous single @entity5 variants in XXXX .

answer: @entity4


abstract: PURPOSE: To validate electronic versions of the Mini Pediatric and Pediatric Asthma Caregiver's Quality of Life Questionnaires (MiniPAQLQ and PACQLQ, respectively), determine completion times and correlate QOL of @entity0 and caregivers. METHODS: A total of 63 @entity0 and 64 caregivers completed the paper and electronic MiniPAQLQ or PACQLQ. Agreement between versions of each questionnaire was summarized by intraclass correlation coefficients (ICC). The correlation between MiniPAQLQ and PACQLQ scores from @entity0 -caregiver pairs was assessed using Pearson's correlation coefficient. RESULTS: There was no significant difference (mean difference  =  0.1, 95  % CI -0.1, 0.2) in MiniPAQLQ Overall Scores between paper (5.9      1.0, mean      SD) and electronic (5.8      1.0) versions, or any of the domains. ICCs ranged from 0.89 (Overall) to 0.86 (Emotional Function). Overall PACQLQ scores for both versions were comparable (5.9      0.9 and 5.8      1.0; mean difference  =  0.0; 95  % CI -0.1, 0.2). ICCs ranged from 0.81 (Activity Limitation) to 0.88 (Emotional Function). The electronic PACQLQ took 26  s longer (95  % CI 11, 41; p  <  0.001). Few @entity0 (3-11  %) preferred the paper format. MiniPAQLQ and PACQLQ scores were significantly correlated (all p  <  0.05) for Overall (r paper  =  0.33, r electronic  =  0.27) and Emotional Function domains (r paper  =  0.34, r electronic  =  0.29). CONCLUSIONS: These electronic QOL questionnaires are valid, and @entity1 -related QOL of @entity0 and caregivers is related.

title: Assessing the burden of childhood XXXX : validation of electronic versions of the Mini Pediatric and Pediatric Asthma Caregiver's Quality of Life Questionnaires.

answer: @entity1


abstract: PURPOSE: The purpose of this study was to evaluate the psychometric properties of the Farsi version of 10-item Functional Outcomes of Sleep Questionnaire (FOSQ-10) in Iranian @entity0 with @entity2 ( @entity2 ). METHODS: The FOSQ-10 was translated into Farsi using the standard forward-backward method. One hundred @entity0 who fulfilled the inclusion criteria completed a series of questionnaires including IR-FOSQ-10, Medical Outcome Survey Short Form 12 (SF-12) and @entity1 ( @entity1 ). Internal consistency, test-retest reliability, concurrent validity, discriminant validity and responsiveness of IR-FOSQ-10 were investigated. RESULTS: The Cronbach's alpha coefficient was 0.85 in IR-FOSQ-10 total score and ranged from 0.78 to 0.83 in each subscale. The test-retest reliability demonstrated by intraclass coefficient was 0.92. There were significant moderate-to-good negative correlations between IR-FOSQ-10 subscales and @entity1 except for sexual relationship subscale. FOSQ-10 subscales generally correlated higher with related subscales of SF-12. The IR-FOSQ-10 was able to distinguish @entity0 with @entity1 score from those with normal sleepiness score. The results of sensitivity to change proved that the IR-FOSQ-10 was able to detect changes after continuous positive airway pressure therapy. CONCLUSION: The psychometric properties of the IR-FOSQ-10 suggest that it is a reliable and valid measure among Iranian @entity0 with @entity2 .

title: Adaptation of the 10-Item Functional Outcomes of Sleep Questionnaire to Iranian XXXX with Obstructive Sleep Apnea.

answer: @entity0


abstract: The objective of this study was to determine the effect of different levels of dietary @entity2 on selected immune parameters of young @entity0 . A total of 357 one-day-old female Hybrid Converter @entity0 were randomly divided into three groups with low, medium and high level of dietary me- @entity3 (LM, MM, HM) of seven replicates each. @entity2 was added to the basal diet (LM) at 0.16% (MM) and 0.32% (HM). At 17 days of age, seven birds per group were vaccinated against @entity1 , with ORNITIN (ABIC) vaccine. At 28 days of age, blood was sampled and the birds were euthanized. The serum concentrations and activity of selected biochemical parameters, total IgY and IgM, and vaccine-induced antibody titers (IgY) against ORT were determined. The percentages of @entity4 +, @entity5 +, @entity4 +/ @entity5 + T cell subpopulations and IgM+ B cell subpopulation were determined in blood and organs by flow cytometry. Different supplementary levels of @entity2 had no significant effect on vaccine-induced anti- body titers against ORT or total serum IgM and IgY levels, as well as on the percentages of periph- eral blood T and B cell subsets. Increasing dietary @entity2 rates decreased the percentage of @entity4 + T cell subpopulation, however it has increased the percentage of IgM+ B cell subpopulation in the spleen. Vaccination against ORT resulted in a significant decrease in the percentage of @entity4 + T cell subset and an increase in the percentage of @entity5 + T cell subset in the spleen. It could be concluded that MM @entity0 have developed the most desirable values of immune parameters.

title: Immunological and biochemical indicators in XXXX fed diets with a different @entity2 content.

answer: @entity0