abstract: Lipoprotein (a) [ @entity3 ] is an independent risk factor for @entity1 -related events that is under strong genetic control (heritability = 0.68-0.98). However, causal mutations and functional validation of biological pathways modulating @entity3 metabolism are lacking. We performed a genome-wide association scan to identify genetic variants associated with @entity3 - @entity0 levels in the Old Order Amish. We confirmed a previously known locus on chromosome 6q25-26 and found @entity3 levels also to be significantly associated with a SNP near the @entity7 - @entity6 - @entity5 - @entity2 gene cluster on chromosome 11q23 linked in the Amish to the @entity5 @entity10 null mutation. On 6q locus, we detected associations of @entity3 - @entity0 with 118 common variants (P = 5 * 10(-8) to 3.91 * 10(-19)) spanning a    5.3 Mb region that included the @entity4 gene. To further elucidate variation within @entity4 , we sequenced @entity4 and identified two variants most strongly associated with @entity3 - @entity0 , @entity9 (P = 1.07 * 10(-14)) and @entity8 (P = 1.85 * 10(-12)). We also measured copy numbers of kringle IV-2 (KIV-2) in @entity4 using qPCR. KIV-2 numbers were significantly associated with @entity3 - @entity0 (P = 2.28 * 10(-9)). Conditional analyses revealed that @entity9 and @entity8 were associated with @entity3 - @entity0 levels independent of each other and KIV-2 copy number. Furthermore, we determined for the first time that levels of @entity4 mRNA were higher in the carriers than non-carriers of @entity8 (P = 0.0001) and were not different between carriers and non-carriers of @entity9 . Protein levels of apo(a) were higher in the carriers than non-carriers of both @entity8 and @entity9 . In summary, we identified multiple independent genetic determinants for @entity3 - @entity0 . These findings provide new insights into @entity3 regulation.

title: Evidence for several independent genetic variants affecting lipoprotein (a) XXXX levels.

answer: @entity0


abstract: BACKGROUND: -Survival following pediatric cardiac extracorporeal life support (ECLS) is guarded and @entity1 varies widely. Our objective is to report our ten-year experience with cardiac ECLS, including survival and kindergarten entry neurocognitive outcomes; to identify predictors of mortality or adverse neurocognitive outcomes; and to compare two eras, before and after 2005. METHODS AND RESULTS: -From 2000-2009, 98 @entity0 had venoarterial cardiac ECLS. Sixty-four @entity0 (65%) survived to hospital discharge and 50 (51%) survived up to 5 years of age. Neurocognitive follow-up of survivors was completed at mean (SD) age of 52.9 (8) months using Wechsler Preschool and Primary Scale of Intelligence. Logistic regression analysis found the longer time (hours) for @entity2 to fall below 2 mmol/L on ECLS (HR 1.39; 95%CI 1.05, 1.84; P= 0.022) and the amount of platelets (ml/kg) given in the first 48 hours (hazard ratio [HR] 1.18; 95% CI 1.06, 1.32; P= 0.002) were independently associated with higher in-hospital mortality. Receiving ECLS after the year 2005 was independently associated with lower risk of in-hospital mortality (HR 0.36; 95%CI 0.13, 0.99; P= 0.048). Extracorporeal cardiopulmonary resuscitation (ECPR) was not independently associated with mortality or neurocognitive outcomes. @entity3 was not independently associated with neurocognitive outcomes. The Full-Scale IQ of survivors without chromosomal abnormalities was 79.7 (16.6) with 25% below 2SD of the population mean. CONCLUSIONS: -Mortality has improved over time; time for @entity2 to fall on ECLS and volume of platelets transfused are independent predictors of mortality. ECPR and @entity3 were not independently associated with neurocognitive outcomes.

title: Survival and Neurocognitive Outcomes After Cardiac Extracorporeal Life Support in XXXX Less Than Five Years of Age: A Ten Year Cohort.

answer: @entity0


abstract: Mindfulness meditation reduces @entity1 in experimental and clinical settings. However, it remains unknown whether mindfulness meditation engages @entity1 -relieving mechanisms other than those associated with the placebo effect (e.g., conditioning, psychosocial context, beliefs). To determine whether the analgesic mechanisms of mindfulness meditation are different from placebo, we randomly assigned 75 healthy, @entity0 volunteers to 4 d of the following: (1) mindfulness meditation, (2) placebo conditioning, (3) sham mindfulness meditation, or (4) book-listening control intervention. We assessed intervention efficacy using psychophysical evaluation of experimental @entity1 and functional neuroimaging. Importantly, all cognitive manipulations (i.e., mindfulness meditation, placebo conditioning, sham mindfulness meditation) significantly @entity1 intensity and unpleasantness ratings when compared to rest and the control condition (p < 0.05). Mindfulness meditation reduced @entity1 intensity (p = 0.032) and @entity1 unpleasantness (p < 0.001) ratings more than placebo @entity2 . Mindfulness meditation also reduced @entity1 intensity (p = 0.030) and @entity1 unpleasantness (p = 0.043) ratings more than sham mindfulness meditation. Mindfulness-meditation-related @entity1 relief was associated with greater activation in brain regions associated with the cognitive modulation of @entity1 , including the orbitofrontal, subgenual anterior cingulate, and anterior insular cortex. In contrast, placebo @entity2 was associated with activation of the dorsolateral prefrontal cortex and deactivation of sensory processing regions (secondary somatosensory cortex). Sham mindfulness meditation-induced @entity2 was not correlated with significant neural activity, but rather by greater reductions in respiration rate. This study is the first to demonstrate that mindfulness-related @entity1 relief is mechanistically distinct from placebo @entity2 . The elucidation of this distinction confirms the existence of multiple, cognitively driven, supraspinal mechanisms for @entity1 modulation. SIGNIFICANCE STATEMENT: Recent findings have demonstrated that mindfulness meditation significantly reduces @entity1 . Given that the "gold standard" for evaluating the efficacy of behavioral interventions is based on appropriate placebo comparisons, it is imperative that we establish whether there is an effect supporting meditation-related @entity1 relief above and beyond the effects of placebo. Here, we provide novel evidence demonstrating that mindfulness meditation produces greater @entity1 relief and employs distinct neural mechanisms than placebo cream and sham mindfulness meditation. Specifically, mindfulness meditation-induced @entity1 relief activated higher-order brain regions, including the orbitofrontal and cingulate cortices. In contrast, placebo @entity2 was associated with @entity1 -related brain activation. These findings demonstrate that mindfulness meditation reduces @entity1 through unique mechanisms and may foster greater acceptance of meditation as an adjunct @entity1 therapy.

title: Mindfulness Meditation-Based Pain Relief Employs Different Neural Mechanisms Than Placebo and Sham Mindfulness Meditation-Induced XXXX .

answer: @entity2


abstract: @entity0 shape their hands to grasp, manipulate objects, and to communicate. From nonhuman primate studies, we know that visual and motor properties for grasps can be derived from cells in the @entity1 ( @entity1 ). Are non-grasp-related hand shapes in @entity0 represented similarly? Here we show for the first time how single neurons in the @entity1 of @entity0 are selective for particular imagined hand shapes independent of graspable objects. We find that motor imagery to shape the hand can be successfully decoded from the @entity1 by implementing a version of the popular Rock-Paper-Scissors game and its extension Rock-Paper-Scissors-Lizard-Spock. By simultaneous presentation of visual and auditory cues, we can discriminate motor imagery from visual information and show differences in auditory and visual information processing in the @entity1 . These results also demonstrate that neural signals from @entity0 @entity1 can be used to drive a dexterous cortical neuroprosthesis. SIGNIFICANCE STATEMENT: This study shows for the first time hand-shape decoding from @entity0 @entity1 . Unlike nonhuman primate studies in which the visual stimuli are the objects to be grasped, the visually cued hand shapes that we use are independent of the stimuli. Furthermore, we can show that distinct neuronal populations are activated for the visual cue and the imagined hand shape. Additionally we found that auditory and visual stimuli that cue the same hand shape are processed differently in @entity1 . Early on in a trial, only the visual stimuli and not the auditory stimuli can be decoded. During the later stages of a trial, the motor imagery for a particular hand shape can be decoded for both modalities.

title: Hand Shape Representations in the XXXX Posterior Parietal Cortex.

answer: @entity0


abstract: UNASSIGNED: For many years, novel strategies for @entity0 detection and treatment using nanoparticles (NPs) have been developed. @entity4 is the sixth leading cause of @entity0 in Western countries, and despite recent advances in early detection and treatment, its prognosis is still very poor. This study investigated the use of fluorescent organic NPs as potential diagnostic tool in an experimental in vivo model of Barrett's @entity4 . NPs were made of modified polysaccharides loaded with @entity7 ( @entity6 ), a well-known fluorescent dye. The NP periphery might or might not be decorated with ASYNYDA peptide that has an affinity for @entity3 cells. Non-operated and operated @entity1 in which gastroesophageal reflux was surgically induced received both types of NPs (NP- @entity6 and NP- @entity6 -ASYNYDA) by intravenous route. Localization of mucosal NPs was assessed in vivo by confocal laser endomicroscopy, a technique which enables a "real time" and in situ visualization of the tissue at a cellular level. After injection of NP- @entity6 and NP- @entity6 -ASYNYDA, fluorescence was observed in @entity1 affected by @entity3 , whereas no signal was observed in control non-operated @entity1 , or in @entity1 with simple @entity5 or @entity2 . Fluorescence was observable in vivo 30 minutes after the administration of NPs. Interestingly, NP- @entity6 -ASYNYDA induced strong fluorescence intensity 24 hours after administration. These observations suggested that NPs could reach the @entity0 cells, likely by enhanced permeability and retention effect, and the peptide ASYNYDA gave them high specificity for @entity3 cells. Thus, the combination of NP platform and confocal laser endomicroscopy could play an important role for highlighting @entity3 conditions. This result supports the potential of this strategy as a targeted carrier for photoactive and bioactive molecules in @entity3 diagnosis and treatment.

title: Detection of fluorescent organic nanoparticles by confocal laser endomicroscopy in a @entity1 model of Barrett's XXXX .

answer: @entity4


abstract: UNASSIGNED: For many years, novel strategies for @entity0 detection and treatment using nanoparticles (NPs) have been developed. @entity4 is the sixth leading cause of @entity0 in Western countries, and despite recent advances in early detection and treatment, its prognosis is still very poor. This study investigated the use of fluorescent organic NPs as potential diagnostic tool in an experimental in vivo model of Barrett's @entity4 . NPs were made of modified polysaccharides loaded with @entity7 ( @entity6 ), a well-known fluorescent dye. The NP periphery might or might not be decorated with ASYNYDA peptide that has an affinity for @entity3 cells. Non-operated and operated @entity1 in which gastroesophageal reflux was surgically induced received both types of NPs (NP- @entity6 and NP- @entity6 -ASYNYDA) by intravenous route. Localization of mucosal NPs was assessed in vivo by confocal laser endomicroscopy, a technique which enables a "real time" and in situ visualization of the tissue at a cellular level. After injection of NP- @entity6 and NP- @entity6 -ASYNYDA, fluorescence was observed in @entity1 affected by @entity3 , whereas no signal was observed in control non-operated @entity1 , or in @entity1 with simple @entity5 or @entity2 . Fluorescence was observable in vivo 30 minutes after the administration of NPs. Interestingly, NP- @entity6 -ASYNYDA induced strong fluorescence intensity 24 hours after administration. These observations suggested that NPs could reach the @entity0 cells, likely by enhanced permeability and retention effect, and the peptide ASYNYDA gave them high specificity for @entity3 cells. Thus, the combination of NP platform and confocal laser endomicroscopy could play an important role for highlighting @entity3 conditions. This result supports the potential of this strategy as a targeted carrier for photoactive and bioactive molecules in @entity3 diagnosis and treatment.

title: Detection of fluorescent organic nanoparticles by confocal laser endomicroscopy in a XXXX model of Barrett's @entity4 .

answer: @entity1


abstract: BACKGROUND: Acute @entity5 comprises a major cause for morbidity in @entity0 with @entity3 which induces an immune inflammatory response that may produce long lasting harmful effects. Currently, there is no effective therapy for @entity5 . OBJECTIVE: Our aim was to investigate the efficacy of five-day montelukast therapy in acute @entity5 management. METHODS: The study included 50 @entity0 with acute @entity5 . The @entity0 with first episode of acute @entity5 were randomly assigned to receive daily montelukast dose of 4mg over five days after admission or no treatment. Plasma eotaxin, @entity4 , @entity2 and @entity1 levels were evaluated before and after treatment by ELISA method. In the present study, the primary outcome measure was change in clinical severity score, whilst secondary outcome measures were changes in plasma eotaxin, @entity4 , @entity2 , @entity1 levels. RESULTS: No significant differences was found in clinical severity score with five-day montelukast treatment (p>0.05, Mann-Whitney U test). There were no significant differences in plasma eotaxin, @entity4 , @entity2 , @entity1 levels between the groups (p>0.05 Mann-Whitney U test). There was significant decrease in plasma @entity1 levels following five-day montelukast treatment (p=0.027, Wilcoxon). There were no significant differences in plasma @entity4 , @entity2 , @entity1 levels between the groups after five-day montelukast treatment (p>0.05, Wilcoxon). There was significant increase in eotaxin levels after five-day montelukast treatment (p=0.009, Wilcoxon). CONCLUSION: Our study showed that montelukast affected plasma @entity1 and eotaxin levels after five days of treatment. Further studies are needed to demonstrate effects of montelukast on chemokine levels in @entity5 .

title: Effect of montelukast on clinical score and cytokine levels of @entity0 for clinically diagnosed acute XXXX .

answer: @entity5


abstract: BACKGROUND: Acute @entity5 comprises a major cause for morbidity in @entity0 with @entity3 which induces an immune inflammatory response that may produce long lasting harmful effects. Currently, there is no effective therapy for @entity5 . OBJECTIVE: Our aim was to investigate the efficacy of five-day montelukast therapy in acute @entity5 management. METHODS: The study included 50 @entity0 with acute @entity5 . The @entity0 with first episode of acute @entity5 were randomly assigned to receive daily montelukast dose of 4mg over five days after admission or no treatment. Plasma eotaxin, @entity4 , @entity2 and @entity1 levels were evaluated before and after treatment by ELISA method. In the present study, the primary outcome measure was change in clinical severity score, whilst secondary outcome measures were changes in plasma eotaxin, @entity4 , @entity2 , @entity1 levels. RESULTS: No significant differences was found in clinical severity score with five-day montelukast treatment (p>0.05, Mann-Whitney U test). There were no significant differences in plasma eotaxin, @entity4 , @entity2 , @entity1 levels between the groups (p>0.05 Mann-Whitney U test). There was significant decrease in plasma @entity1 levels following five-day montelukast treatment (p=0.027, Wilcoxon). There were no significant differences in plasma @entity4 , @entity2 , @entity1 levels between the groups after five-day montelukast treatment (p>0.05, Wilcoxon). There was significant increase in eotaxin levels after five-day montelukast treatment (p=0.009, Wilcoxon). CONCLUSION: Our study showed that montelukast affected plasma @entity1 and eotaxin levels after five days of treatment. Further studies are needed to demonstrate effects of montelukast on chemokine levels in @entity5 .

title: Effect of montelukast on clinical score and cytokine levels of XXXX for clinically diagnosed acute @entity5 .

answer: @entity0


abstract: UNASSIGNED: Keratinocytes constitute the majority of cells in the skin's epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish @entity1 , however the response of keratinocytes to invading cercariae has not been investigated. Here we address the hypothesis that cercariae activate epidermal keratinocytes to promote the development of a pro-inflammatory immune response in the skin. C57BL/6 @entity0 were exposed to @entity2 cercariae via each pinna and non-haematopoietic cells isolated from epidermal tissue were characterised for the presence of different keratinocyte sub-sets at 6, 24 and 96 h p.i. We identified an expansion of epidermal keratinocyte precursors ( @entity5 (-), CD326(-), @entity6 (+)) within 24 h of @entity1 relative to na  ve animals. Following @entity1 , cells within the precursor population displayed a more differentiated phenotype (a6integrin(-)) than in uninfected skin. Parallel immunohistochemical analysis of pinnae cryosections showed that this expansion corresponded to an increase in the intensity of @entity6 staining, specifically in the basal bulge region of hair follicles of infected @entity0 , and a higher frequency of keratinocyte precursor Ki67(+) nuclei in both the hair follicle and interfollicular epidermis. Expression of pro-inflammatory cytokine and stress-associated @entity7 genes was also transiently upregulated in the epidermal tissue of infected @entity0 . In vitro exposure of keratinocyte precursors isolated from neonatal @entity0 skin to excretory/secretory (E/S) antigens released by penetrating cercaraie elicited @entity3 and @entity4 production, supporting a role for keratinocyte precursors in initiating cutaneous inflammatory immune responses. Together, these observations indicate that @entity2 cercariae and their E/S products act directly upon epidermal keratinocytes, which respond by initiating barrier repair and pro-inflammatory mechanisms similar to those observed in epidermal wound healing.

title: Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity1 ( @entity1 ) @entity0 in the leave-without-being-seen (LWBS) group risk problems of inefficiency, medical risk, and financial loss. The goal at our hospital is to limit LWBS to <1%. This study's goal was to assess the influence on LWBS associated with prolonging intervals between @entity0 presentation and placement in an exam room (DoorRoom time). This study' @entity2 aim was to identify DoorRoom cutoffs that maximize likelihood of meeting the LWBS goal (i.e. <1%). METHODS: We conducted the study over one year (8/13-8/14) using operations data for an @entity1 with annual census ~50,000. For each study day, the LWBS endpoint (i.e. was LWBS <1%: "yes or no") and the mean DoorRoom time were recorded. We categorized DoorRoom means by intervals starting with  <=10min and ending at >60min. Multivariate logistic regression was used to assess for DoorRoom cutoffs predicting high LWBS, while adjusting for @entity0 acuity (triage scores and admission %) and operations parameters. We used predictive marginal probability to assess utility of the regression-generated cutoffs. We defined statistical significance at p<0.05 and report odds ratio (OR) and 95% confidence intervals (CI). RESULTS: Univariate results suggested a primary DoorRoom cutoff of 20', to maintain a high likelihood (>85%) of meeting the LWBS goal. A secondary DoorRoom cutoff was indicated at 35', to prevent a precipitous drop-off in likelihood of meeting the LWBS goal, from 61.1% at 35' to 34.4% at 40'. Predictive marginal analysis using multivariate techniques to control for operational and @entity0 -acuity factors confirmed the 20' and 35' cutoffs as significant (p<0.001). Days with DoorRoom between 21-35' were 74% less likely to meet the LWBS goal than days with DoorRoom  <=20' (OR 0.26, 95% CI [0.13-0.53]). Days with DoorRoom >35' were a further 75% less likely to meet the LWBS goal than days with DoorRoom of 21-35' (OR 0.25, 95% CI [0.15-0.41]). CONCLUSION: Operationally useful DoorRoom cutoffs can be identified, which allow for rational establishment of performance goals for the @entity1 attempting to minimize LWBS.

title: Identifying XXXX Door-to-Room Goals to Minimize Left-Without-Being-Seen Rates.

answer: @entity0


abstract: OBJECTIVE: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) allows preoperative tissue confirmation of malignancy, but fear of @entity1 cell dissemination along the needle track has limited its use. We hypothesised that if @entity1 cell dissemination occurs with EUS-FNA, survival after complete resection would be impaired. We aimed to evaluate the association of preoperative EUS-FNA with long-term outcomes of @entity0 with resected @entity3 . DESIGN: Using the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we identified @entity0 with locoregional @entity3 who underwent curative intent surgery from 1998 to 2009. The @entity0 who received EUS-FNA within the peridiagnostic period were included in the EUS-FNA group. @entity0 who did not receive EUS evaluation or who underwent EUS without FNA were included in the non-EUS-FNA group. Overall survival and @entity3 -specific survival were compared after controlling for relevant covariates. RESULTS: A total of 2034 @entity0 with @entity3 were included (90% @entity3 ). Of these, 498 (24%) @entity0 were in EUS-FNA group. @entity0 with multiple comorbidities and more recent diagnosis were more likely to receive EUS-FNA. In multivariate analysis, after controlling for age, race, gender, @entity1 histology, @entity1 stage, @entity1 grade, @entity1 location, SEER site, year of diagnosis, undergoing percutaneous aspiration/biopsy, Charlson Comorbidity Index, radiation and chemotherapy, EUS-FNA was marginally associated with improved overall survival (HR 0.84, 95% CI 0.72 to 0.99), but did not affect @entity1 -specific survival (HR 0.87, 95% CI 0.74 to 1.03). CONCLUSIONS: Preoperative EUS-FNA was not associated with increased risk of mortality. These data suggest that EUS-FNA can be safely performed for the work-up of suspicious @entity2 .

title: Preoperative endoscopic ultrasound-guided fine needle aspiration does not impair survival of @entity0 with resected XXXX .

answer: @entity3


abstract: OBJECTIVE: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) allows preoperative tissue confirmation of malignancy, but fear of @entity1 cell dissemination along the needle track has limited its use. We hypothesised that if @entity1 cell dissemination occurs with EUS-FNA, survival after complete resection would be impaired. We aimed to evaluate the association of preoperative EUS-FNA with long-term outcomes of @entity0 with resected @entity3 . DESIGN: Using the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare data, we identified @entity0 with locoregional @entity3 who underwent curative intent surgery from 1998 to 2009. The @entity0 who received EUS-FNA within the peridiagnostic period were included in the EUS-FNA group. @entity0 who did not receive EUS evaluation or who underwent EUS without FNA were included in the non-EUS-FNA group. Overall survival and @entity3 -specific survival were compared after controlling for relevant covariates. RESULTS: A total of 2034 @entity0 with @entity3 were included (90% @entity3 ). Of these, 498 (24%) @entity0 were in EUS-FNA group. @entity0 with multiple comorbidities and more recent diagnosis were more likely to receive EUS-FNA. In multivariate analysis, after controlling for age, race, gender, @entity1 histology, @entity1 stage, @entity1 grade, @entity1 location, SEER site, year of diagnosis, undergoing percutaneous aspiration/biopsy, Charlson Comorbidity Index, radiation and chemotherapy, EUS-FNA was marginally associated with improved overall survival (HR 0.84, 95% CI 0.72 to 0.99), but did not affect @entity1 -specific survival (HR 0.87, 95% CI 0.74 to 1.03). CONCLUSIONS: Preoperative EUS-FNA was not associated with increased risk of mortality. These data suggest that EUS-FNA can be safely performed for the work-up of suspicious @entity2 .

title: Preoperative endoscopic ultrasound-guided fine needle aspiration does not impair survival of XXXX with resected @entity3 .

answer: @entity0


abstract: UNASSIGNED: Although @entity2 ( @entity1 ) is well documented in the literature, no studies have concentrated on the morphology of the cranial base. This study aimed to evaluate the endocranial morphology in @entity0 with @entity1 . Consecutive @entity0 with unilateral @entity1 treated at a craniofacial center from 2000 to 2012 were included. The @entity0 were grouped according to severity on the basis of the Kaban-Pruzansky classification: mild (0-1), moderate (2a), and severe (2b-3). Skull base angulation and transverse craniometric measures were recorded and then compared with those of age-matched controls.A total of 30 @entity0 (14 males, 16 females) averaging 7.5 years of age (range, 1.1-15.7 y) were included. Four @entity0 were classified as mild; 12, as moderate; and 14, as severe. The mean cranial base angle was found to be between 179 and 181 degrees with no significant difference between the severity groups (P = 0.57). The mean cranial base angle did not differ significantly in the @entity0 compared with the controls(179.6 vs 180.0; P = 0.51) No significant differences between the affected and unaffected sides in the @entity0 were found in distances from the midline to hypoglossal canal, internal acoustic meatus, lateral carotid canal, medial carotid canal, foramen ovale, and rotundum. There were no significant differences in transverse measurements between the severity classes using the same landmarks (P = 0.46, P = 0.30, P = 0.40, P = 0.25, P = 0.57, and P = 0.76, respectively). The cranial base axis is not deviated in the @entity0 with @entity1 compared with the age-matched controls, and there exists little difference in endocranial morphologic measurements with increasing severity of @entity1 . These data are interesting, given the role of the cranial base in facial growth and the varying hypotheses regarding the mechanism of disease in @entity1 .

title: Cranial Base Deviation in XXXX by Craniometric Analysis.

answer: @entity1


abstract: The risk of @entity1 of an @entity4 increases with size. It has thus been recommended that small @entity2 be continuously followed with some type of imaging technique to detect when @entity2 size constitutes an indication for surgery. The present study focuses on the growth rate of @entity4 in 35 @entity0 who were subjected to repeated computerized tomographic examinations of their @entity4 . Several @entity2 were measured more than twice resulting in 57 different examinations. The mean growth rate of the transverse diameter was 0.52 cm/year. The individual growth rates were, however, variable. @entity2 with an initial transverse diameter exceeding 6 cm showed a slightly but not significantly faster increase in size compared with smaller @entity2 . No correlation between initial size and growth rate could be established. Six @entity0 died during the study period, two from @entity3 , three after elective @entity2 operations and one, refused for elective operation, died after @entity1 . It is concluded that the growth rate measured with computed tomography agrees well with previously reported estimates obtained with ultrasonography. It is recommended that small @entity2 particularly in @entity0 with relative contraindications to surgery be followed with repeated examinations of size.

title: Growth rate of XXXX as measured by computed tomography.

answer: @entity4


abstract: UNASSIGNED: The purpose of this review was to evaluate the efficacy and safety of qigong for @entity1 .A systematic literature search was performed in 7 databases from their respective inceptions until April 2014, including the Cochrane Library, EMBASE, PubMed, Chinese Scientific Journal Database, Chinese Biomedical Literature Database, Wanfang database, and Chinese National Knowledge Infrastructure. Randomized controlled trials of qigong as either monotherapy or adjunctive therapy with antihypertensive drugs versus no intervention, exercise, or antihypertensive drugs for @entity1 were identified. The risk of bias was assessed using the tool described in Cochrane Handbook for Systematic Review of Interventions, version 5.1.0.Twenty trials containing 2349 @entity1 @entity0 were included in the meta-analysis. The risk of bias was generally high. Compared with no intervention, qigong significantly reduced systolic blood pressure (SBP) ( @entity2 [ @entity2 ]=-17.40mm Hg, 95% confidence interval [CI] -21.06 to -13.74, P<0.00001) and diastolic blood pressure (DBP) ( @entity2 =-10.15mm Hg, 95% CI -13.99 to -6.30, P<0.00001). Qigong was inferior to exercise in decreasing SBP ( @entity2 =6.51mm Hg, 95% CI 2.81 to 10.21, P=0.0006), but no significant difference between the effects of qigong and exercise on DBP ( @entity2 =0.67mm Hg, 95% CI -1.39 to 2.73, P=0.52) was identified. Compared with antihypertensive drugs, qigong produced a clinically meaningful but not statistically significant reduction in SBP ( @entity2 =-7.91mm Hg, 95% CI -16.81 to 1.00, P=0.08), but appeared to be more effective in lowering DBP ( @entity2 =-6.08mm Hg, 95% CI -9.58 to -2.58, P=0.0007). Qigong plus antihypertensive drugs significantly lowered both SBP ( @entity2 =-11.99mm Hg, 95% CI -15.59 to -8.39, P<0.00001) and DBP ( @entity2 =-5.28mm Hg, 95% CI, -8.13 to -2.42, P=0.0003) compared with antihypertensive drugs alone. No serious adverse events were reported.The meta-analysis suggests that qigong is an effective therapy for @entity1 . However, more rigorously designed randomized controlled trials with long-term follow-up focusing on hard clinical outcomes are required to confirm the results.

title: Qigong for XXXX : A Systematic Review.

answer: @entity1


abstract: Ninety-one laparotomy-staged (LAP) IA and IIA @entity1 ( @entity1 ) @entity0 were analyzed to evaluate the prognostic significance of stage, mediastinal status, extranodal disease and histology. Forty IA @entity0 were treated with radiotherapy (XRT) only; of 51 IIA @entity0 , 44 received XRT only and 7 had additional chemotherapy. Disease-free survival (DFS) at 5 and 10 years was 81% and 70%, respectively, with overall survival (S) of 93% and 86%, respectively. Disease-free survival for IA @entity0 (93% at 5 and 10 years) was significantly superior to IIA (73% at 5 years, 52% at 10 years). Survival differences were not statistically significant. For IIA @entity0 receiving XRT only, large @entity2 was an adverse factor for DFS. Small @entity2 in IIA was significantly better than no @entity2 . For the whole group of LAP IA and IIA treated by XRT only, three prognostic groups were identified: (1) Stage IA and Stage IIA with @entity2 , but less than 7.5 cm in width was highly favorable with less than 10% relapse; (2) Stage IIA nonmediastinal had an intermediate prognosis with relapse in about 33%; (3) Stage IIA large mediastinal (greater than or equal to 7.5 cm) had an unfavorable DFS with relapse in about 55%. The third group contained a highly unfavorable subset with mediastinal masses greater than 10 cm, all of whom relapsed. Salvage therapy was successful in 60% of relapsing @entity0 . In the context of relatively effective salvage therapy, the role of adjuvant chemotherapy in adverse prognostic groups is discussed and it is concluded that the only clearly justifiable use for adjuvant chemotherapy is in @entity0 with massive (greater than 10 cm) mediastinal adenopathy.

title: Laparotomy-staged IA versus IIA XXXX . A comparative study with evaluation of prognostic factors for stage IIA disease.

answer: @entity1


abstract: BACKGROUND: Fixed-dose combination antiretroviral therapy administered as a single-tablet regimen (STR) may improve virologic suppression rates. The effect of STRs on development of resistance when virologic failure occurs on STRs is not known. OBJECTIVES: To compare the rate of emergent drug resistance mutations (DRMs) on first-line therapy with coformulated @entity6 ( @entity1 )/ @entity3 ( @entity4 )/efavirenz ( @entity2 ) as an STR versus @entity1 , @entity5 ( @entity5 ) or @entity4 , and @entity2 given as non-STR. METHODS: @entity0 from eight cohorts and four randomized clinical trials who received first-line antiretroviral therapy with Atripla (STR group) or with @entity1 + @entity4 / @entity5 + @entity2 (non-STR group) were eligible if a genotypic resistance test was available immediately after the first episode of viral failure. The DRM list from the 2013 version of IAS-USA was used. RESULTS: One hundred and eighty-six @entity0 were included in the final analysis, 122 (65.6%) from eight cohorts and 64 (34.1%) from four randomized clinical trials. The overall proportion of @entity0 with at least one DRM at viral failure was 67.7%, including 53.4% (31 of 58) in the STR group vs. 74.2% (95 of 128) in the non-STR group (P=0.005). Among @entity0 exclusively from cohorts, at least one DRM was detected in 53.4% (31 of 58) in the STR group vs. 78.1% (50 of 64) in the non-STR group (P=0.004). DRMs for individual drugs were: @entity1 , 15.5 vs. 16.4% (P=0.87); @entity5 / @entity4 , 31 vs. 35.2% (P=0.58); and NNRTI, 51.7 vs. 65.6% (P=0.07). The proportion of @entity0 with an @entity7 /I among the 128 @entity0 who received @entity4 was 32.8 vs. 36.2% among the 58 treated with @entity5 (P=0.65). CONCLUSIONS: Compared to @entity0 receiving the STR-Atripla, those receiving the same components individually in a non-STR regimen have a statistically significantly increased risk of selecting for DRMs associated with their drugs on failure.

title: Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovir+ XXXX / @entity5 +efavirenz administered on a multiple tablet therapy.

answer: @entity3


abstract: BACKGROUND: Fixed-dose combination antiretroviral therapy administered as a single-tablet regimen (STR) may improve virologic suppression rates. The effect of STRs on development of resistance when virologic failure occurs on STRs is not known. OBJECTIVES: To compare the rate of emergent drug resistance mutations (DRMs) on first-line therapy with coformulated @entity6 ( @entity1 )/ @entity3 ( @entity4 )/efavirenz ( @entity2 ) as an STR versus @entity1 , @entity5 ( @entity5 ) or @entity4 , and @entity2 given as non-STR. METHODS: @entity0 from eight cohorts and four randomized clinical trials who received first-line antiretroviral therapy with Atripla (STR group) or with @entity1 + @entity4 / @entity5 + @entity2 (non-STR group) were eligible if a genotypic resistance test was available immediately after the first episode of viral failure. The DRM list from the 2013 version of IAS-USA was used. RESULTS: One hundred and eighty-six @entity0 were included in the final analysis, 122 (65.6%) from eight cohorts and 64 (34.1%) from four randomized clinical trials. The overall proportion of @entity0 with at least one DRM at viral failure was 67.7%, including 53.4% (31 of 58) in the STR group vs. 74.2% (95 of 128) in the non-STR group (P=0.005). Among @entity0 exclusively from cohorts, at least one DRM was detected in 53.4% (31 of 58) in the STR group vs. 78.1% (50 of 64) in the non-STR group (P=0.004). DRMs for individual drugs were: @entity1 , 15.5 vs. 16.4% (P=0.87); @entity5 / @entity4 , 31 vs. 35.2% (P=0.58); and NNRTI, 51.7 vs. 65.6% (P=0.07). The proportion of @entity0 with an @entity7 /I among the 128 @entity0 who received @entity4 was 32.8 vs. 36.2% among the 58 treated with @entity5 (P=0.65). CONCLUSIONS: Compared to @entity0 receiving the STR-Atripla, those receiving the same components individually in a non-STR regimen have a statistically significantly increased risk of selecting for DRMs associated with their drugs on failure.

title: Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovir+ @entity3 / XXXX +efavirenz administered on a multiple tablet therapy.

answer: @entity5


abstract: OBJECTIVES:: Previous studies have evaluated whether @entity5 is associated with @entity3 incidence and outcomes with conflicting conclusions. In this study, we evaluate the incidence of @entity3 in @entity2 @entity0 treated with and without @entity5 compared with nondiabetic @entity0 . MATERIALS AND METHODS:: One thousand thirty-four @entity0 underwent transperineal template-guided mapping biopsy secondary to either an elevated @entity4 or a prior biopsy finding of atypical small acinar proliferation/ @entity6 . The cohort included 881 nondiabetic @entity0 , 65 @entity2 @entity0 treated with @entity5 , and 88 @entity2 @entity0 not receiving @entity5 . In @entity5 -treated @entity0 , the median duration of usage was 6.0 years. Differences in @entity3 diagnosis, histologic grade, and @entity1 volume were compared across the 3 cohorts. RESULTS:: There was no statistically significant differences discerned between the 3 cohorts in @entity0 age, prebiopsy @entity4 , prostate volume, @entity4 density, @entity4 doubling time, @entity4 velocity, or the total number of prior transrectal ultrasound biopsy sessions. Five hundred eighty-four @entity0 were diagnosed with @entity3 . There was no difference in @entity3 diagnosis (P=0.153), Gleason score (P=0.960), the number of positive biopsy cores (P=0.764), or risk group stratification (P=0.877) between the 3 cohorts. In multivariate analysis, only older age predicted for @entity3 diagnosis. In terms of Gleason score >= 7, @entity0 age, @entity4 velocity, and body mass index predicted for more aggressive histology. Neither @entity2 , @entity5 use or duration was of statistical consequence. CONCLUSION:: @entity5 did not impact incidence of @entity3 diagnosis, Gleason score distribution, or volume of disease.

title: @entity5 Does Not Predict for XXXX Diagnosis, Grade, or Volume of Disease After Transperineal Template-guided Mapping Biopsy.

answer: @entity3


abstract: OBJECTIVES:: Previous studies have evaluated whether @entity5 is associated with @entity3 incidence and outcomes with conflicting conclusions. In this study, we evaluate the incidence of @entity3 in @entity2 @entity0 treated with and without @entity5 compared with nondiabetic @entity0 . MATERIALS AND METHODS:: One thousand thirty-four @entity0 underwent transperineal template-guided mapping biopsy secondary to either an elevated @entity4 or a prior biopsy finding of atypical small acinar proliferation/ @entity6 . The cohort included 881 nondiabetic @entity0 , 65 @entity2 @entity0 treated with @entity5 , and 88 @entity2 @entity0 not receiving @entity5 . In @entity5 -treated @entity0 , the median duration of usage was 6.0 years. Differences in @entity3 diagnosis, histologic grade, and @entity1 volume were compared across the 3 cohorts. RESULTS:: There was no statistically significant differences discerned between the 3 cohorts in @entity0 age, prebiopsy @entity4 , prostate volume, @entity4 density, @entity4 doubling time, @entity4 velocity, or the total number of prior transrectal ultrasound biopsy sessions. Five hundred eighty-four @entity0 were diagnosed with @entity3 . There was no difference in @entity3 diagnosis (P=0.153), Gleason score (P=0.960), the number of positive biopsy cores (P=0.764), or risk group stratification (P=0.877) between the 3 cohorts. In multivariate analysis, only older age predicted for @entity3 diagnosis. In terms of Gleason score >= 7, @entity0 age, @entity4 velocity, and body mass index predicted for more aggressive histology. Neither @entity2 , @entity5 use or duration was of statistical consequence. CONCLUSION:: @entity5 did not impact incidence of @entity3 diagnosis, Gleason score distribution, or volume of disease.

title: XXXX Does Not Predict for @entity3 Diagnosis, Grade, or Volume of Disease After Transperineal Template-guided Mapping Biopsy.

answer: @entity5


abstract: STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To evaluate if @entity0 with @entity1 ( @entity1 ) show a greater lumbar reposition error (RE) than healthy controls. SUMMARY OF BACKGROUND DATA: Studies on lumbar RE in @entity0 with @entity1 present conflicting results. METHODS: A systematic review and meta-analysis of the available literature were performed to evaluate differences in RE between @entity0 with @entity1 and healthy controls. Data on absolute error, constant error (CE), and variable error were extracted and effect sizes (ESs) were calculated. For the CE flexion pattern and active extension pattern, subgroups of @entity0 with @entity1 were analyzed. Results of homogeneous studies were pooled. Measurement protocols and study outcomes were compared. The quality of reporting and the authors' appraisal of risk of bias were investigated. RESULTS: The original search revealed 178 records of which 13 fulfilled the inclusion criteria. The majority of studies showed that @entity0 with @entity1 produced a significantly larger absolute error (ES, 0.81; 95% confidence interval [95% CI], 0.13-1.49) and variable error (ES, 0.57; 95% CI, 0.05-1.09) compared with controls. CE is direction specific in flexion and active extension pattern subgroups of @entity0 with @entity1 (ES, 0.39; 95% CI, -1.09 to 0.3) and ES, 0.18; 95% CI, -0.3 to 0.65, respectively). The quality of reporting and the authors' appraisal of risk of bias varied considerably. The applied test procedures and instrumentation varied between the studies, which hampered the comparability of studies. CONCLUSION: Although @entity0 with @entity1 seemed to produce a larger lumbar RE compared with healthy controls, study limitations render firm conclusions unsafe. Future studies should pay closer attention to power, precision, and reliability of the measurement approach, definition of outcome measures, and @entity0 selection. We recommend a large, well-powered, prospective randomized control study that uses a standardized measurement approach and definitions for @entity2 , and variable error to address the hypothesis that proprioception may be impaired with CLBP. LEVEL OF EVIDENCE: 1.

title: Measuring Lumbar Reposition Accuracy in XXXX With Unspecific Low Back Pain: Systematic Review and Meta-analysis.

answer: @entity0


abstract: UNASSIGNED: @entity6 are rare neoplasms that mainly affect @entity0 . They include @entity5 , @entity5 , and @entity3 . Detailed genetic studies are rare, and information about their molecular pathogenesis is limited. Molecular inversion probe analysis is a hybridization-based method that represents a reliable tool for the analysis of highly fragmented @entity4 -fixed paraffin-embedded tissue-derived DNA. Here, analysis of 62 cases showed frequent hyperdiploidy in @entity5 and @entity5 that appeared very similar in their cytogenetic profiles. In contrast, @entity3 showed mainly losses of chromosomes. Besides recurrent focal chromosomal gains common to all @entity6 , including chromosome 14q21-q22 (harboring @entity7 ), chromosome 7q22 ( @entity8 ), and chromosome 9q21.12 ( @entity9 ), Genomic Identification of Significant Targets in Cancer analysis uncovered focal alterations specific for @entity5 and @entity5 (e.g. 7p21.3 [ @entity11 ]) and for @entity3 (16p13.3 [ @entity10 ] and 6p21 [POLH, @entity12 , @entity13 , and @entity2 ]). Additional RNA expression profiling and gene set enrichment analysis revealed greater expression of cell cycle-related genes in @entity5 in comparison with that in @entity5 . These findings suggest that @entity5 represent an immature variant of @entity5 characterized by increased proliferative activity, whereas @entity3 seem to represent a genetically distinct @entity1 group.

title: High-Resolution Genomic Analysis Does Not Qualify Atypical Plexus Papilloma as a Separate Entity Among XXXX .

answer: @entity6


abstract: BACKGROUND: The extent of breast and chest-wall deformity varies widely in @entity4 , and a variety of techniques are required to correct them. The aim of this study is to analyse our experience and long-term follow-up, and to propose an algorithmic approach to this @entity1 . @entity0 AND METHODS: Retrospective case-note review from a prospectively maintained database was carried out on 37 @entity0 . All @entity0 treated between 1993 and 2013 were reviewed, and long-term outcome was assessed by an objective photographic documentation. The @entity0 were invited to a photographic documentation, and the correlation between the subjective judgement and objective results in the late course was analysed. Based on our experience, we propose an algorithmic approach to this complex skeletal and soft-tissue deformity. RESULTS: Medical photographs were obtained from 32 @entity0 (22 females and 10 males). The age range was 11-44 years. Significant reduction in asymmetry was possible in all @entity0 . The mean follow-up time was 8.5 years (range, 2.2-20). The complex developmental defect involved the skin, subcutaneous tissue, breast, muscle, ribs and other @entity3 . The following treatments were applied alone or in combination: lipomodelling, liposuction, tissue expansion and implants, custom-made prosthesis, islanded pedicled latissimus dorsi muscle flaps, pedicled and free muscle-sparing transverse rectus abdominis flaps, prosthetic chest-wall reconstruction and various combinations including multistage procedures. Surgery on the contralateral breast in female and male @entity0 was necessary in 22 @entity0 (20 female and two male). Assessment of the late result by four non-professionals (two females and two males) and one male plastic surgeon showed that the objective aesthetic results of the authors' reconstructions according to the proposed algorithm were sufficient. CONCLUSIONS: @entity4 is a @entity2 in which several tissues are involved. It is crucial to have an armamentarium of techniques to tackle a variety of defects to meet @entity0 ' expectations, and to improve their quality of life. The clinical outcome of the currently presented algorithm proved beneficial in the decision process for the treatment of these @entity1 .

title: Integrated algorithm for reconstruction of complex forms of XXXX : 20-year outcomes.

answer: @entity4


abstract: OBJECTIVE: The purpose of this study was to evaluate the clinical utility and validity of using a pupillometer to assess @entity0 with acute @entity1 . METHODS: Pupillary examinations using an automated pupillometer (NeurOptics  NPi   -100 Pupillometer) were performed every 4 hours and were simultaneously assessed using the Glasgow @entity3 Scale (GCS) and for @entity2 ( @entity2 ), from admission to discharge or expire in neuro-intensive care unit (NICU). @entity5 were also recorded for comparison. By comparing these data, we evaluated the validity of using automated pupillometers to predict clinical outcomes. RESULTS: The mean values of the Neurologic Pupillary index (NPi) were different in the groups examined manually. The GCS correlated well with NPi values, especially in severe @entity4 @entity0 (GCS below 9). However, the NPi values were weakly correlated with @entity2 ( @entity2 ) when the @entity2 was lower than 30 cm @entity6 . The NPi value was not affected by age or intensity of illumination. In @entity0 with a "poor" prognosis who had a Glasgow Outcome Scale (GOS) of 1 or 2, the mean initial NPi score was 0.88  1.68, whereas the value was 3.89  0.97 in @entity0 with a "favorable" prognosis who had a GOS greater than 2 (p<0.001). For predicting clinical outcomes, the initial NPi value of 3.4 had the highest sensitivity and specificity. CONCLUSION: An automated pupillometer can serve as a simple and useful tool for the accurate measurement of pupillary reactivity in @entity0 with acute @entity1 .

title: Clinical Utility of an Automated Pupillometer in @entity0 with Acute XXXX .

answer: @entity1


abstract: OBJECTIVE: The purpose of this study was to evaluate the clinical utility and validity of using a pupillometer to assess @entity0 with acute @entity1 . METHODS: Pupillary examinations using an automated pupillometer (NeurOptics  NPi   -100 Pupillometer) were performed every 4 hours and were simultaneously assessed using the Glasgow @entity3 Scale (GCS) and for @entity2 ( @entity2 ), from admission to discharge or expire in neuro-intensive care unit (NICU). @entity5 were also recorded for comparison. By comparing these data, we evaluated the validity of using automated pupillometers to predict clinical outcomes. RESULTS: The mean values of the Neurologic Pupillary index (NPi) were different in the groups examined manually. The GCS correlated well with NPi values, especially in severe @entity4 @entity0 (GCS below 9). However, the NPi values were weakly correlated with @entity2 ( @entity2 ) when the @entity2 was lower than 30 cm @entity6 . The NPi value was not affected by age or intensity of illumination. In @entity0 with a "poor" prognosis who had a Glasgow Outcome Scale (GOS) of 1 or 2, the mean initial NPi score was 0.88  1.68, whereas the value was 3.89  0.97 in @entity0 with a "favorable" prognosis who had a GOS greater than 2 (p<0.001). For predicting clinical outcomes, the initial NPi value of 3.4 had the highest sensitivity and specificity. CONCLUSION: An automated pupillometer can serve as a simple and useful tool for the accurate measurement of pupillary reactivity in @entity0 with acute @entity1 .

title: Clinical Utility of an Automated Pupillometer in XXXX with Acute @entity1 .

answer: @entity0


abstract: UNASSIGNED: The simultaneous occurrence of an intracranial and a @entity5 ( @entity4 ) is rare. We describe a case of cranial @entity4 with a simultaneous spinal @entity4 . An 82-year-old @entity0 visited the emergency room because of drowsiness and not being able to walk 6 weeks after falling down. A neurological examination showed a @entity1 . Brain computed tomography showed bilateral chronic @entity4 with an acute component. The @entity0 underwent an emergency burr-hole trephination and @entity2 removal. She exhibited good recovery after the operation. On the fourth postoperative day, she complained of @entity3 radiating to both lower limbs, and subjective weakness of the lower limbs. Spine magnetic resonance imaging revealed a thoracolumbosacral @entity4 . A follow-up spinal magnetic resonance imaging study that was performed 16 days later showed a significant decrease in the size of the spinal @entity4 . We discuss the pathogenesis of this simultaneous occurrence of spinal and cranial @entity4 .

title: XXXX Associated with Intracranial Subdural Hematoma.

answer: @entity5


abstract: A 54-year-old female living in Europe presented with @entity7 , @entity2 , and bilateral @entity1 . Magnetic resonance imaging (MRI) revealed non-specific white matter changes. The @entity0 's condition gradually deteriorated over two years without diagnosis. The @entity0 continued to decline cognitively and neurologically with @entity3 and upper motor neuron signs. Repeat MRI showed worsening white matter changes. Lumbar puncture, not previously done, showed positive Lyme testing. Treatment with intravenous @entity5 resulted in marked neurological improvement. Four years after symptom, the @entity0 has short-term @entity4 and chronic fatigue, but is otherwise neurologically, cognitively, and functionally intact. Follow up MRI findings remain largely unchanged. Because cases of @entity6 in America are lacking, so are treatment options. We present a rare case and discuss our experience with antibiotic treatment. This case lends evidence to define optimal treatment of this disease, imperative for hastening neurological recovery.

title: A case of chronic progressive lyme encephalitis as a manifestation of XXXX .

answer: @entity6


abstract: AIM: To test the hypothesis that lymphocyte infiltration in brain @entity3 (bAVM) is not associated with @entity1 (indicator of microhemorrhage). METHODS: Sections of unruptured, previously untreated bAVM specimens (n=19) were stained immunohistochemically for T-lymphocytes (CD3(+)), B-lymphocytes ( @entity2 (+)), plasma cells (CD138(+)) and macrophages ( @entity0 (+)). @entity1 was assessed by hematoxylin and eosin and Prussian blue stains. Superficial temporal arteries (STA) were used as control. RESULTS: Both T lymphocytes and macrophages were present in unruptured, previously untreated bAVM specimens, whereas few B cells and plasma cells were detected. @entity1 was detected in 8 specimens (42%; 95% confidence interval =20-67%). The samples with @entity1 tended to have more macrophages than those without (666  313 vs 478  174 cells/mm(2); P=0.11). T-cells were clustered on the luminal side of the endothelial surface, on the vessel-wall, and in the perivascular regions. There was no correlation between T lymphocyte load and @entity1 (P=0.88). No macrophages and lymphocytes were detected in STA controls. CONCLUSIONS: T-lymphocytes were present in bAVM specimens. Unlike macrophages, the load and location of T-lymphocytes were not associated with @entity1 , suggesting the possibility of an independent cell-mediated immunological mechanism in bAVM pathogenesis.

title: Distinctive distribution of lymphocytes in unruptured and previously untreated brain XXXX .

answer: @entity3


abstract: UNASSIGNED: Wearable devices have been popularly used with @entity0 from different age groups. As a consequence, the concerns of their electromagnetic field (EMF) exposure to the @entity0 body and their electromagnetic interference (EMI) to the implanted medical devices have attracted many studies. The aim of this study was to evaluate the @entity0 exposure to the EMF of an active radiofrequency identification (RFID) armlet as well as its EMI to the @entity1 ( @entity1 ). Different @entity0 models from various age groups were applied to assess the result variability. The scalar potential finite element method was utilized in the simulation. Local EMF exposure and the exposure to the central nerve system tissues were evaluated using different metrics. EMI to the @entity1 was assessed in terms of the conducted voltage to the @entity1 . The results from all the models revealed that the studied RFID armlet would not produce the EMF exposure exceeding the safety limits. The calculated interference voltage was highly dependent on the distance between the RFID armlet and the @entity1 (i.e. the physical dimension of the individual model). The results proposed to evaluate the appropriateness of the current EMI measurement protocol for this kind of devices used by the @entity0 .

title: Dosimetry of electromagnetic field exposure of an active armlet and its electromagnetic interference to the cardiac pacemakers using adult, XXXX and @entity0 models.

answer: @entity0


abstract: UNASSIGNED: Wearable devices have been popularly used with @entity0 from different age groups. As a consequence, the concerns of their electromagnetic field (EMF) exposure to the @entity0 body and their electromagnetic interference (EMI) to the implanted medical devices have attracted many studies. The aim of this study was to evaluate the @entity0 exposure to the EMF of an active radiofrequency identification (RFID) armlet as well as its EMI to the @entity1 ( @entity1 ). Different @entity0 models from various age groups were applied to assess the result variability. The scalar potential finite element method was utilized in the simulation. Local EMF exposure and the exposure to the central nerve system tissues were evaluated using different metrics. EMI to the @entity1 was assessed in terms of the conducted voltage to the @entity1 . The results from all the models revealed that the studied RFID armlet would not produce the EMF exposure exceeding the safety limits. The calculated interference voltage was highly dependent on the distance between the RFID armlet and the @entity1 (i.e. the physical dimension of the individual model). The results proposed to evaluate the appropriateness of the current EMI measurement protocol for this kind of devices used by the @entity0 .

title: Dosimetry of electromagnetic field exposure of an active armlet and its electromagnetic interference to the cardiac pacemakers using adult, @entity0 and XXXX models.

answer: @entity0


abstract: " NlmCategory=: Invasive and noninvasive methods for evaluating the effects of hemodynamics on progression of @entity7 ( @entity7 ) in @entity0 with @entity5 ( @entity5 ) have been proposed. @entity4 ( @entity4 ) has been reported to be the best among selected measures of hemodynamics for predicting @entity7 . However, there are few studies examining the relation between longitudinal changes in @entity4 and @entity2 in @entity0 with @entity5 . METHODS: Sixty-seven @entity0 with @entity5 stages 3-5 (female/male ratio: 26/41, age: 61.5    13.1 years) were followed for 5 years. Before and at the end of the 5-year period, @entity4 was recorded by an automated tonometric system (HEM-9000 AI; Omron Healthcare, Kyoto, Japan). Second systolic aortic blood pressure ( @entity8 ) was employed as an index of @entity4 . RESULTS: Throughout the study, systolic blood pressure (SBP) was well controlled. Renal function followed by estimated glomerular filtration rate (eGFR) gradually worsened as a whole. Ten @entity0 had renal replacement therapy, 3 @entity0 developed @entity3 and 2 @entity0 were found to have a @entity1 during the 5-year observation period. @entity8 increased from 120    19 to 125    33 mm Hg and eGFR decreased from 38.2    18.2 to 29.5    16.3 ml/min/1.73 m(2); however, these differences did not achieve significance. The @entity6 ( @entity6 ) index significantly increased from 115.5    10.5 to 131.2    11.7 g/m(2) (p < 0.05). Although the changes in @entity8 and eGFR looked like a mirror image, there was no significant correlation between the two factors. Moreover, multivariate regression analysis did not reveal a close correlation between @entity8 and @entity5 progression. In contrast to the decline of renal function, the baseline value of @entity8 predicted an increase in the @entity6 index. CONCLUSION: Worsening of @entity2 is not solely dependent on hemodynamics. Other factors might be involved in a complex manner.

title: Decline of Renal Function and Progression of XXXX Are Independently Determined in @entity5 Stages 3-5.

answer: @entity7


abstract: " NlmCategory=: Invasive and noninvasive methods for evaluating the effects of hemodynamics on progression of @entity7 ( @entity7 ) in @entity0 with @entity5 ( @entity5 ) have been proposed. @entity4 ( @entity4 ) has been reported to be the best among selected measures of hemodynamics for predicting @entity7 . However, there are few studies examining the relation between longitudinal changes in @entity4 and @entity2 in @entity0 with @entity5 . METHODS: Sixty-seven @entity0 with @entity5 stages 3-5 (female/male ratio: 26/41, age: 61.5    13.1 years) were followed for 5 years. Before and at the end of the 5-year period, @entity4 was recorded by an automated tonometric system (HEM-9000 AI; Omron Healthcare, Kyoto, Japan). Second systolic aortic blood pressure ( @entity8 ) was employed as an index of @entity4 . RESULTS: Throughout the study, systolic blood pressure (SBP) was well controlled. Renal function followed by estimated glomerular filtration rate (eGFR) gradually worsened as a whole. Ten @entity0 had renal replacement therapy, 3 @entity0 developed @entity3 and 2 @entity0 were found to have a @entity1 during the 5-year observation period. @entity8 increased from 120    19 to 125    33 mm Hg and eGFR decreased from 38.2    18.2 to 29.5    16.3 ml/min/1.73 m(2); however, these differences did not achieve significance. The @entity6 ( @entity6 ) index significantly increased from 115.5    10.5 to 131.2    11.7 g/m(2) (p < 0.05). Although the changes in @entity8 and eGFR looked like a mirror image, there was no significant correlation between the two factors. Moreover, multivariate regression analysis did not reveal a close correlation between @entity8 and @entity5 progression. In contrast to the decline of renal function, the baseline value of @entity8 predicted an increase in the @entity6 index. CONCLUSION: Worsening of @entity2 is not solely dependent on hemodynamics. Other factors might be involved in a complex manner.

title: Decline of Renal Function and Progression of @entity7 Are Independently Determined in XXXX Stages 3-5.

answer: @entity5


abstract: UNASSIGNED: @entity3 affects millions of @entity0 in Latin America. The control of this @entity5 focuses on halting transmission by reducing or eliminating insect vector populations. Most transmission of @entity4 , the causative agent of @entity3 , involves insects living within or very close to households and feeding mostly on domestic animals. As animal hosts can be intermittently present it is important to understand how host availability can modify transmission risk to @entity0 and to characterize the host-seeking dispersal of triatomine vectors on a very fine scale. We used a semi-field system with motion-detection cameras to characterize the dispersal of Triatoma infestans, and compare the behavior of vector populations in the constant presence of hosts ( @entity1 ), and after the removal of the hosts. The emigration rate - net insect population decline in original refuge - following host removal was on average 19.7% of insects per 10 days compared to 10.2% in constant host populations (p=0.029). However, @entity2 . infestans occurred in both directions, towards and away from the initial location of the hosts. The majority of insects that moved towards the original location of @entity1 remained there for 4 weeks. Oviposition and mortality were observed and analyzed in the context of insect dispersal, but only mortality was higher in the group where animal hosts were removed (p-value <0.01). We discuss different survival strategies associated with the observed behavior and its implications for vector control. Removing domestic animals in infested areas increases vector dispersal from the first day of host removal. The implications of these patterns of vector dispersal in a field setting are not yet known but could result in movement towards @entity0 rooms.

title: Host-Seeking Behavior and Dispersal of Triatoma infestans, a Vector of XXXX , under Semi-field Conditions.

answer: @entity3


abstract: BACKGROUND: @entity4 receptor antagonists have been shown to reduce perioperative @entity1 and opioid use. The authors performed a meta-analysis to determine whether the use of perioperative @entity6 lowers @entity5 or @entity1 scores. METHODS: PubMed, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Pubget, and EMBASE were searched. Studies were included if they were randomized, double-blinded, placebo-controlled trials written in English, and performed on @entity0 12 yr or older. For comparison of opioid use, included studies tracked total consumption of IV or intramuscular opioids over 24 to 48 h. @entity1 score comparisons were performed at 1, 4 to 6, and 24   h postoperatively. Difference in means ( @entity2 ) was used for effect size. RESULTS: Forty studies were identified and 21 were eligible for one or more comparisons. In 848 @entity0 from 14 trials, @entity5 favored @entity6 ( @entity2 , -10.51 mg IV @entity3 equivalents; 95% CI, -16.48 to -4.53 mg; P = 0.0006). In 884 @entity0 from 13 trials, @entity1 at 1 h favored @entity6 ( @entity2 , -1.60; 95% CI, -1.89 to -1.31; P < 0.00001). In 950 @entity0 from 13 trials, @entity1 at 4 to 6 h favored @entity6 ( @entity2 , -0.89; 95% CI, -1.11 to -0.66; P < 0.00001). In 797 @entity0 from 12 trials, @entity1 at 24 h favored @entity6 ( @entity2 , -0.92; 95% CI, -1.24 to -0.60; P < 0.00001). CONCLUSION: This meta-analysis suggests that @entity6 use perioperatively reduces the postoperative @entity5 at 24 to 48 h and @entity1 scores at 1, 4 to 6, and 24 h.

title: Perioperative XXXX as an Adjunct for Postoperative Pain: A Meta-analysis of Randomized Controlled Trials.

answer: @entity6


abstract: PURPOSE: Prolonged sedentary time (ST) is associated with cardiovascular risk factors (CV-RF) independent of physical activity (PA). Whether a high level of @entity2 ( @entity2 ) can modify the deleterious health consequences related to high ST is not known. METHODS: We performed a cross-sectional study of 12,274 @entity0 and 14,209 @entity0 (>= 20 yr) without known @entity1 . Self-reported ST measurements during a regular day were divided into three sex-specific equally sized groups ( <=4, 5 to <7, and >= 7 h  d). @entity2 was estimated (eCRF) using a previously validated nonexercise model. Using logistic regression analyses, adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated for the association of ST with CV-RF clustering and for the potential modifying effect of eCRF. RESULTS: Each hour increase in ST was associated with 5% and 4% greater likelihood of having CV-RF clustering independent of PA in @entity0 and @entity0 , respectively. Among the @entity0 with higher levels of eCRF, the adjusted OR values associated with >= 7 h  d of ST were 0.92 (0.56-1.51) for @entity0 and 1.16 (0.49-2.74) for @entity0 , compared with @entity0 and @entity0 with low ST ( <=4 h  d) and high eCRF levels. In combined analyses of eCRF, PA, and ST, compared with the reference group of @entity0 meeting the recommendations,  <=4 h  d of ST and high eCRF, the OR values were 0.63 (0.27-1.44) and 0.65 (0.14-3.07) in fit @entity0 and @entity0 with >= 7 h  d of ST, which did not meet the recommendations. @entity0 and @entity0 meeting the PA recommendations, but were unfit, had significantly increased odds of having CV-RF clustering across levels of ST. CONCLUSION: High levels of eCRF abolished the increased odds of having CV-RF clustering associated with high ST, even among those individuals who did not meet the current PA recommendations.

title: XXXX , Sedentary Time, and @entity1 .

answer: @entity2


abstract: PURPOSE: Prolonged sedentary time (ST) is associated with cardiovascular risk factors (CV-RF) independent of physical activity (PA). Whether a high level of @entity2 ( @entity2 ) can modify the deleterious health consequences related to high ST is not known. METHODS: We performed a cross-sectional study of 12,274 @entity0 and 14,209 @entity0 (>= 20 yr) without known @entity1 . Self-reported ST measurements during a regular day were divided into three sex-specific equally sized groups ( <=4, 5 to <7, and >= 7 h  d). @entity2 was estimated (eCRF) using a previously validated nonexercise model. Using logistic regression analyses, adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated for the association of ST with CV-RF clustering and for the potential modifying effect of eCRF. RESULTS: Each hour increase in ST was associated with 5% and 4% greater likelihood of having CV-RF clustering independent of PA in @entity0 and @entity0 , respectively. Among the @entity0 with higher levels of eCRF, the adjusted OR values associated with >= 7 h  d of ST were 0.92 (0.56-1.51) for @entity0 and 1.16 (0.49-2.74) for @entity0 , compared with @entity0 and @entity0 with low ST ( <=4 h  d) and high eCRF levels. In combined analyses of eCRF, PA, and ST, compared with the reference group of @entity0 meeting the recommendations,  <=4 h  d of ST and high eCRF, the OR values were 0.63 (0.27-1.44) and 0.65 (0.14-3.07) in fit @entity0 and @entity0 with >= 7 h  d of ST, which did not meet the recommendations. @entity0 and @entity0 meeting the PA recommendations, but were unfit, had significantly increased odds of having CV-RF clustering across levels of ST. CONCLUSION: High levels of eCRF abolished the increased odds of having CV-RF clustering associated with high ST, even among those individuals who did not meet the current PA recommendations.

title: @entity2 , Sedentary Time, and XXXX .

answer: @entity1


abstract: OBJECTIVE: The objective of our study was to retrospectively determine the prevalence and image findings of extraarticular @entity5 with os sustentaculum, a type of @entity5 that does not appear in current classification systems, in @entity0 with an imaging diagnosis of foot coalition. MATERIALS AND METHODS: This study was performed using a database query of radiology reports of ankle and foot CT or MRI examinations performed from August 2001 to November 2013. Eighty-one @entity0 were identified through a keyword search of the database for " @entity5 ," " @entity4 ," "coalition," or "os sustentaculum." Imaging features of CT or MRI findings were evaluated. Chart review was used to identify demographic information. RESULTS: Extraarticular @entity5 with os sustentaculum was diagnosed in 13 @entity0 (nine @entity0 , four @entity0 ), which represents a prevalence of 16.0% (13/81) in all foot coalitions and 24.1% (13/54) in all @entity5 . Four of 13 @entity0 underwent surgical resection, and histology was obtained in three @entity0 . Nine @entity0 who had no history of @entity1 were symptomatic and all @entity0 with @entity2 at the coalition sites on MRI (n = 5) were also symptomatic. Coexisting extraarticular @entity5 with os sustentaculum and @entity3 were observed in 11 of 13 @entity0 . CONCLUSION: The os sustentaculum is a component of extraarticular @entity5 and as such is usually related to the presence of symptoms. If a @entity0 with an os sustentaculum has symptoms in the medial talocalcaneal joint area, an extraarticular @entity5 related to the os sustentaculum should be considered.

title: A Different Type of XXXX With Os Sustentaculum: The Continued Necessity of Revision of Classification.

answer: @entity5


abstract: OBJECTIVE: To study the effects of Kangai injection on the enzyme activities of macrophages and morphology of spleen and thymus from @entity0 . METHODS: Twenty four male SD @entity0 were randomly divided into two groups (n = 12), normal control group and experimental group. The @entity0 in experimental group were injected with Kangai injection at the dosage of 5 ml/kg x d for 30 days peritoneally and those in control group were injected with nomal saline at the same volume. The content of supermicro protein was assayed by BCA method, the activities of lactate dehydrogenase (LDH), glutathione peroxidase( @entity2 ), and @entity1 ( @entity1 ) from alveolar macrophages(AM) and peritoneal macrophages (PM) were detected biochemically. The activities of acid phosphatase (ACP), superoxide dismutase(SOD) and succinate dehydrogenase (SDH) from AM and PM were detected by ELISA. The morphology of spleen and thymus were observed by light microscopy. RESULTS: The activities of LDH, @entity2 and @entity1 within AM and PM from experimental group were increased significantly compared with those of control group (P < 0.05). The activities of ACP, SOD and SDH in AM and PM from experimental group were also higher than those from control group (P < 0.05). Microscopically, there was thickening of peripheral arterial lymphatic sheath, enlargement of splenic lymphoid nodules with expended germinal center in the spleen of experimental group. There was no significant difference in the mophology of thymus between the two groups. CONCLUSION: Kangai injection may improve immune function by activating macrophages.

title: [The effects of Kangai injection on enzyme activities of macrophages in XXXX ].

answer: @entity0


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Nepal, a mountainous country having diversified topographic and climatic conditions, gives rise to a wide range of flora and fauna. In villages ethnic @entity0 , including Magar and Majhi highly depend on medicinal plants for their primary healthcare. Due to overexploitation, encroachment in forest for arable land and destruction of natural habitat, potentially useful medicinal plants are going to be threatened in their natural environment. There is a strong need to enlist highly valuable medicinal plants and use traditional knowledge to protect, utilize and manage them in ex-situ and in-situ conservation. The present research investigates and documents traditional knowledge on medicinal plants utilization as natural medicine by two ethnic communities Magar and Majhi of Parbat district in Western Nepal. METHODS: Ethnomedicinal data was collected during 2012-2013 by the following standard ethnobotanical methods. Data about medicinal uses of herbs, shrubs and trees were collected using semi-structured questionnaire, field observation, personal interview and group discussion with 334 (130 @entity0 and 204 @entity0 ) pre-identified local informants, among which 13 male and 2 female were local healers. Statistical tool, informant consensus factors ( @entity3 ) and fidelity level (FL) values were used to analyze the importance of ethnomedicinal plants. RESULTS: A total of 132 ethnomedicinal plant species belonging to 99 genera and 67 families have been documented. These plants are used to treat @entity1 and disorders grouped under 12 disease categories, with the highest number of species (61) being used for gastro-intestinal, @entity2 ( @entity3 =0.78%), followed by blood and lymphatic system ( @entity3 =0.76%) category. The highest fidelity level (FL) values recorded in Paris polyphylla (FL=96.0%) followed by Bergenia ciliata (FL=95.0%) confirms that these plants are the best plant species with medicinal properties. CONCLUSIONS: The two ethnic communities, Magar and Majhi, in Parbat district are rich in ethnomedicinal knowledge. The high degree of consensus among the informants suggests that current use and knowledge are still strong, and thus the preservation of indigenous knowledge would show good foresight in acting before much has been lost.

title: An ethnobotanical study of medicinal plants used by ethnic XXXX in Parbat district of western Nepal.

answer: @entity0


abstract: UNASSIGNED: @entity6 ( @entity7 ) has recently been identified as an endogenous gaseous signaling molecule. In the vascular system, the formation of @entity7 is catalyzed by @entity8  y  -lyase (CSE). Previous studies have demonstrated the protective effects of @entity7 on @entity2 in various types of tissue. However,, little is known about the role of @entity7 in @entity1 -associated @entity4 . Thus, the aim of the present study was to examine the possible role of @entity7 in high @entity3 -induced @entity4 , and to explore the underlying mechanisms. @entity0 umbilical vein endothelial cells (HUVECs) were isolated from @entity0 umbilical veins. The levels of @entity7 following treatment with various levels of @entity3 were determined and the secretion of @entity5 ( @entity5 ) was measured by ELISA. The mRNA and protein expression of CSE in the HUVECs was determined by real-time RT-PCR and western blot analysis, respectively. Treatment with high @entity3 (25  mmol/l) for 48  h significantly increased the secretion of @entity5 by HUVECs, with the concomitant suppression of @entity7 production and CSE protein expression. The increase in exogenous @entity7 levels through the administration of @entity9 ( @entity9 ) attenuated the high @entity3 -induced downregulation of CSE protein expression, and significantly inhibited the secretion of @entity5 . These results suggest that the downregulation of CSE protein expression and the subsequent decrease in @entity7 production play a role in high @entity3 -induced @entity4 possibly by increasing the secretion of @entity5 by endothelial cells.

title: High @entity3 induces the release of @entity5 through the inhibition of XXXX production in HUVECs.

answer: @entity6


abstract: UNASSIGNED: @entity6 ( @entity7 ) has recently been identified as an endogenous gaseous signaling molecule. In the vascular system, the formation of @entity7 is catalyzed by @entity8  y  -lyase (CSE). Previous studies have demonstrated the protective effects of @entity7 on @entity2 in various types of tissue. However,, little is known about the role of @entity7 in @entity1 -associated @entity4 . Thus, the aim of the present study was to examine the possible role of @entity7 in high @entity3 -induced @entity4 , and to explore the underlying mechanisms. @entity0 umbilical vein endothelial cells (HUVECs) were isolated from @entity0 umbilical veins. The levels of @entity7 following treatment with various levels of @entity3 were determined and the secretion of @entity5 ( @entity5 ) was measured by ELISA. The mRNA and protein expression of CSE in the HUVECs was determined by real-time RT-PCR and western blot analysis, respectively. Treatment with high @entity3 (25  mmol/l) for 48  h significantly increased the secretion of @entity5 by HUVECs, with the concomitant suppression of @entity7 production and CSE protein expression. The increase in exogenous @entity7 levels through the administration of @entity9 ( @entity9 ) attenuated the high @entity3 -induced downregulation of CSE protein expression, and significantly inhibited the secretion of @entity5 . These results suggest that the downregulation of CSE protein expression and the subsequent decrease in @entity7 production play a role in high @entity3 -induced @entity4 possibly by increasing the secretion of @entity5 by endothelial cells.

title: High XXXX induces the release of @entity5 through the inhibition of @entity6 production in HUVECs.

answer: @entity3


abstract: UNASSIGNED: @entity6 ( @entity7 ) has recently been identified as an endogenous gaseous signaling molecule. In the vascular system, the formation of @entity7 is catalyzed by @entity8  y  -lyase (CSE). Previous studies have demonstrated the protective effects of @entity7 on @entity2 in various types of tissue. However,, little is known about the role of @entity7 in @entity1 -associated @entity4 . Thus, the aim of the present study was to examine the possible role of @entity7 in high @entity3 -induced @entity4 , and to explore the underlying mechanisms. @entity0 umbilical vein endothelial cells (HUVECs) were isolated from @entity0 umbilical veins. The levels of @entity7 following treatment with various levels of @entity3 were determined and the secretion of @entity5 ( @entity5 ) was measured by ELISA. The mRNA and protein expression of CSE in the HUVECs was determined by real-time RT-PCR and western blot analysis, respectively. Treatment with high @entity3 (25  mmol/l) for 48  h significantly increased the secretion of @entity5 by HUVECs, with the concomitant suppression of @entity7 production and CSE protein expression. The increase in exogenous @entity7 levels through the administration of @entity9 ( @entity9 ) attenuated the high @entity3 -induced downregulation of CSE protein expression, and significantly inhibited the secretion of @entity5 . These results suggest that the downregulation of CSE protein expression and the subsequent decrease in @entity7 production play a role in high @entity3 -induced @entity4 possibly by increasing the secretion of @entity5 by endothelial cells.

title: High @entity3 induces the release of XXXX through the inhibition of @entity6 production in HUVECs.

answer: @entity5


abstract: UNASSIGNED: Aims: Closure of @entity4 ( @entity4 ) is non-inferior to medical treatment for @entity0 with cryptogenic @entity1 . Results in randomised trials might be based on the different types of used occluders. We determined residual shunting with serial contrast transoesophageal echocardiography (cTEE) and evaluated rates of recurrent cerebrovascular events in a long-term follow-up. Methods and results: cTEE was repeated three and 12 months after @entity4 closure using AMPLATZER (n=109), BioSTAR (n=68), @entity2 (n=104) or Premere (n=54) occluders. Closure was demonstrated in 91.6% and 95.9% of @entity0 after three and 12 months. Closure rates were not different among groups (p=0.58; p=0.94). The @entity4 diameter was a risk factor for residual shunting (p=0.02), but not the prevalence of an @entity3 ( @entity3 ). During follow-up, including 1,815 @entity0 -years (PY), eight @entity0 suffered a @entity1 (0.44/100 PY) and seven @entity0 a transient ischaemic attack (0.39/100 PY). Rates of recurrent cerebrovascular events were similar among the four groups. Conclusions: Closure at three or 12 months (as measured by cTEE) and rates of recurrent cerebrovascular events were similar among occluder groups. @entity4 diameter was a risk factor for residual shunting, but not the presence of @entity3 . The rate of recurrent cerebral ischaemic events was low.

title: Efficacy of different devices for transcatheter closure of XXXX assessed by serial transoesophageal echocardiography and rates of recurrent cerebrovascular events in a long-term follow-up.

answer: @entity4


abstract: PURPOSE: We evaluated the risk of @entity2 reclassification by time on active surveillance. MATERIALS AND METHODS: From 1995 to 2014 we evaluated 557 and 251 @entity0 at very low and at low risk, respectively, who were on active surveillance and compliant with prostate biopsies. Our primary study outcome was reclassification to higher risk disease by grade or extent. Freedom from reclassification was estimated using the Kaplan-Meier approach with adjustment for covariates using the Cox proportional hazards model. RESULTS: Within the first 2 years of surveillance @entity0 survival free of reclassification by grade (p = 0.20) and by any biopsy criteria (p = 0.25) was similar in @entity0 with very low and @entity1 . After 2 years @entity0 with @entity1 were 2.4 times more likely to be diagnosed with a Gleason score of greater than 6  than @entity0 with very @entity1 (p = 0.002, HR 2.4, 95% CI 1.9-3.5). Additionally, beyond 2 years on surveillance the risk of lifetime reclassification by grade and by any criteria decreased by 30% and 35% (each p <0.0001, HR 0.70, 95% CI 0.60-0.76 and HR 0.65, 95% CI 0.57-0.72, respectively) with each biopsy that showed no reclassification. CONCLUSIONS: The reclassification rate during surveillance is not equally distributed across time or risk groups. Due to misclassification at diagnosis the reclassification rate in very low and low risk groups is similar in the first 2 years but differs significantly beyond 2 years. The risk of reclassification decreases with time for each nonreclassifying biopsy beyond 2 years.

title: Conditional Probability of Reclassification in an Active Surveillance Program for XXXX .

answer: @entity2


abstract: OBJECTIVE: Occupational @entity5 are a worldwide problem. Certain occupations pose a greater risk than others. Recent statistics on global @entity6 and diseases that might lead to @entity4 and even worse might lead to @entity2 , are staggering. The purpose of this study was to estimate the @entity2 rates from @entity6 in Jordan over a period of four years; to estimate occupational fatality rate that results from @entity0 and identify the most risky concurrent occupations with the type of @entity0 , the age and nationality of the victims. METHOD: A total of 88 work related @entity5 were admitted to three hospitals in Amman through 2008-2012 and were examined by a forensic (occupational) physician at the time. They were categorized according to, age, nationality, occupation, @entity0 and were all tested for toxic substances. RESULTS: The occupation with the most @entity5 was construction (44%); falling from a height was the commonest type of accident (44%) and @entity3 were the leading injury type (21.6%); 9.1% of the @entity2 were positive for @entity1 . Moreover, 22.7% of @entity2 were between ages of 25-29. Consequently, the mean occupational fatality rate was 2 per 100.000 workers during 2008-2012. CONCLUSION: Constructions and other types of occupations are more extensive problems than what is usually anticipated, especially when safety precautions are not effective or implemented. They may cause @entity0 and @entity2 , which will have a socioeconomic burden on families, society, governments and industries. Not to mention the grief that is associated with the @entity2 of a worker at his work site to all concerned parties.

title: Occupational XXXX in Jordan.

answer: @entity5


abstract: Behaviour of the filtration of red blood cells (rbc) passed through a filter paper was investigated. The rbc were incubated in fractions of blood plasma with different molecular mass (MM). By means of an Amicon membrane XM-50 the separation of plasma from healthy and @entity1 @entity0 ( @entity0 ) was performed into two parts of different molecular sizes one of these was the concentrate (MM more than 50 000 = K) and the other was the ultrafiltrate (MM below 50 000 = UF). By a second step the UF was divided (Amicon membrane UM-50 into an UF1 (MM below 500) and into an UF2 (MM 500 to 50 000). In addition a hemofiltrate (MM below 5 000) was used for the incubation too. This hemofiltrate was made form pooled plasma of healthy and @entity1 @entity0 , respectively. Rbc was incubated in both different fractions of plasma and hemofiltrate at a temperature of 37 degrees C and for a duration of 60 min. The pH-level and the osmolality were physiological. Under the influence of @entity1 UF the flexibility of rbc was clearly decreased. The UF1 had the most effect of the decrease of flexibility. Therefore the small substances which are easy dialysable play also an important role in the damage of rbc in the @entity2 .

title: [Effect of XXXX plasma fractions of different molecular sizes on the filterability of red blood cells].

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Prophylactic anticoagulation for @entity2 prevention after @entity4 ( @entity4 ) is safe. Current guidelines recommend prophylactic anticoagulation after cessation of @entity3 growth. We aimed to evaluate nationwide trends in @entity2 prophylaxis after @entity4 . METHODS: In an analysis of the Premier database, we identified adult @entity0 with @entity4 (International Classification of Diseases Ninth edition code 431) from 2006 to 2010 who survived to day 2 of hospitalization. We excluded those with @entity1 or who underwent craniotomy or angiography. We abstracted type of anticoagulant used and date of first administration. We used univariate statistics and multivariable logistic regression to assess factors associated with prophylactic anticoagulation after @entity4 . RESULTS: Among 32 690 (mean age, 69.7 years; 50.1% @entity0 ) @entity0 with spontaneous @entity4 , 5395 (16.5%) @entity0 received any prophylactic anticoagulation during the hospital stay. Among these @entity0 , 2416 (44.8%) received prophylactic anticoagulation by day 2. The most commonly used agents were heparin (71.1%), enoxaparin (27.5%), and dalteparin (1.4%). The proportion of @entity0 receiving prophylactic anticoagulation increased slightly during the study period from 14.3% to 18.0% (P<0.01 for trend). Use of prophylactic anticoagulation varied by geographic region (P<0.001) in the United States: Northeast (23.2%), South (19.0%), Midwest (10.8%), and West (9.8%). In multivariable analysis, geographic region remained an independent predictor of prophylactic anticoagulation. CONCLUSIONS: Less than 20% of @entity0 with @entity4 receive anticoagulation for @entity2 in the United States. When used, the time to initiation is <2 days in less than half of the @entity0 . Further study should focus on understanding variations in practice and emphasize guideline-driven care.

title: Is Prophylactic Anticoagulation for Deep Venous Thrombosis Common Practice After XXXX ?

answer: @entity4


abstract: UNASSIGNED: Aims: To investigate the relationship between @entity4 and @entity1 in @entity3 ( @entity3 ). Methods: A total of 108 subjects affected by @entity3 were subdivided into subjects without delusions ( @entity8 ), subjects with @entity7 ( @entity7 ), subjects with @entity6 ( @entity6 ), subjects with both @entity6 and @entity7 ( @entity6 + @entity7 ), subjects with @entity5 ( @entity5 ), and subjects without @entity5 (N-HALL). Results: @entity7 and @entity8 subjects performed similarly on neuropsychological tests, while @entity6 @entity0 performed significantly worse than @entity7 and @entity8 @entity0 . @entity5 @entity0 performed worse than N-HALL @entity0 on memory, visuospatial, and executive functions. As for behavioral features, @entity6 and @entity5 subjects reported higher scores on the abnormal motor behavior subscale of the neuropsychiatric inventory (NPI); @entity7 subjects reported higher scores on the disinhibition subscale of the NPI. The severity of @entity7 was predicted by the severity of disinhibition (B = 0.514; p = 0.016) but not by neuropsychological performances. The severity of @entity6 was predicted by age (B = 0.099; p = 0.048) and MMSE (B = -0.233; p = 0.001). The severity of @entity5 was predicted by age (B = 0.052; p = 0.037) and scores on an immediate visual memory task (B = -0.135; p = 0.007). Conclusions: The occurrence of @entity7 may require the relative sparing of cognitive functions and be @entity2 , while @entity6 is associated with the overall level of @entity1 . Finally, @entity5 are associated with the impairment of visuospatial abilities.    2015 S. Karger AG, Basel.

title: Cognitive and Behavioral Determinants of Psychotic Symptoms in XXXX .

answer: @entity3


abstract: @entity2 ( @entity2 ) is a complex disease involving @entity1 . An association of the @entity4 polymorphism with @entity2 was reported in Caucasian populations of Europe and North America, as well as in Japanese populations. The present study aimed to examine whether the @entity2 -associated SNP @entity5 of @entity4 gene confer susceptibility to @entity2 and clinical features of @entity2 in a Han Chinese population. A Han Chinese cohort consisting of 424 @entity2 @entity0 and 502 healthy controls were examined in the study. TaqMan assays were carried out to examine the SNP. Exact p-values were obtained (Fisher  s test) from 2x2 tables of allele counts and disease status. @entity2 @entity0 of Han Chinese showed increased homozygous TT genotype of the @entity5 (p = 0.027, odds ratio (OR) = 1.4, CI =1.03-1.93), which was significantly associated with @entity3 of @entity2 and ATA-positive @entity2 of Han Chinese. The lcSSc and ACA-positive @entity2 of Han Chinese appeared also in association with the increased T allele frequency. However, the Chinese dcSSc did not show any association with the @entity5 . The results were consistent with previous reports in other ethnic populations in supporting the notion that polymorphisms of @entity4 may play an important role in susceptibility to @entity2 .

title: ASSOCIATION OF THE @entity4 SNP XXXX WITH SYSTEMIC SCLEROSIS IN HAN CHINESE.

answer: @entity5


abstract: @entity2 ( @entity2 ) is a complex disease involving @entity1 . An association of the @entity4 polymorphism with @entity2 was reported in Caucasian populations of Europe and North America, as well as in Japanese populations. The present study aimed to examine whether the @entity2 -associated SNP @entity5 of @entity4 gene confer susceptibility to @entity2 and clinical features of @entity2 in a Han Chinese population. A Han Chinese cohort consisting of 424 @entity2 @entity0 and 502 healthy controls were examined in the study. TaqMan assays were carried out to examine the SNP. Exact p-values were obtained (Fisher  s test) from 2x2 tables of allele counts and disease status. @entity2 @entity0 of Han Chinese showed increased homozygous TT genotype of the @entity5 (p = 0.027, odds ratio (OR) = 1.4, CI =1.03-1.93), which was significantly associated with @entity3 of @entity2 and ATA-positive @entity2 of Han Chinese. The lcSSc and ACA-positive @entity2 of Han Chinese appeared also in association with the increased T allele frequency. However, the Chinese dcSSc did not show any association with the @entity5 . The results were consistent with previous reports in other ethnic populations in supporting the notion that polymorphisms of @entity4 may play an important role in susceptibility to @entity2 .

title: ASSOCIATION OF THE XXXX SNP @entity5 WITH SYSTEMIC SCLEROSIS IN HAN CHINESE.

answer: @entity4


abstract: UNASSIGNED: @entity0 are living longer but morbidity has also increased; threatening to create a serious global burden. Our approach is to monitor gait for early warning signs of morbidity. Here we present highlights from a series of experiments into gait as a potential biomarker for @entity1 ( @entity1 ), ageing and fall risk. Using body-worn accelerometers, we developed several novel camera-less methods to analyze head and pelvis movements while walking. Signal processing algorithms were developed to extract gait parameters that represented the principal components of vigor, head jerk, lateral harmonic stability, and oscillation range. The new gait parameters were compared to accidental falls, mental state and co-morbidities. We observed: 1) @entity0 with @entity1 had significantly larger and uncontrolled anterioposterior (AP) oscillations of the head; 2) Older @entity0 walked with more lateral head jerk; and, 3) the combination of vigorous and harmonically stable gait was demonstrated by non-fallers. Our findings agree with research from other groups; changes in @entity0 gait reflect changes to well-being. We observed; different aspects of gait reflected different functional outcomes. The new gait parameters therefore may be complementary to existing methods and may have potential as biomarkers for specific disorders. However, further research is required to validate our observations, and establish clinical utility.

title: Gait as a biomarker? Accelerometers reveal that reduced movement quality while walking is associated with XXXX , ageing and fall risk.

answer: @entity1


abstract: UNASSIGNED: Bone architecture as size and shape is important for bone strength and risk of @entity1 . Most @entity2 is cortical and occurs by trabecularisation of the inner part of the cortex. We therefore wanted to identify determinants of the bone architecture, especially the area and porosity of the transitional zone, an inner cortical region with a large surface/matrix volume available for intracortical @entity3 . In 211 postmenopausal @entity0 aged 54-94 years with @entity1 and 232 controls from the Troms   Study, Norway, we quantified femoral subtrochanteric architecture in CT images using StrAx1.0 software, and serum levels of bone turnover markers (BTM). Multivariable linear and logistic regression analyses were used to quantify associations of age, weight, height, and bone size with bone architecture and BTM, and odds ratio (OR) for @entity1 . Increasing age, height and larger total cross-sectional area (TCSA) were associated with larger transitional zone @entity4 and transitional zone @entity4 /TCSA (standardized coefficients (STB)   =   0.11-0.80, p  <= 0.05). Increasing weight was associated with larger TCSA, but smaller transitional zone @entity4 /TCSA and thicker cortices (STB   =   0.15-0.22, p   <   0.01). Increasing height and TCSA were associated with higher porosity of the transitional zone (STB   =   0.12-0.46, p   <   0.05). Increasing BTM were associated with larger TCSA, larger transitional zone @entity4 /TCSA and higher porosity of each of the cortical compartments (p   <   0.01). @entity1 cases exhibited larger transitional zone @entity4 and higher porosity than controls (p   <   0.001). Per SD increasing @entity4 and porosity of the transitional zone, OR for @entity1 was 1.71 (95% confidence interval 1.37-2.14) and 1.51 (1.23-1.85). Cortical bone architecture is determined mainly by bone size as built during growth and is modified by lifestyle factors throughout life through bone turnover. @entity1 cases exhibited larger transitional zone area and porosity, highlighting the importance of cortical bone architecture for @entity1 propensity. This article is protected by copyright. All rights reserved.

title: Determinants of Transitional Zone Area and Porosity of the Proximal Femur Quantified In Vivo in Postmenopausal XXXX .

answer: @entity0


abstract: BACKGROUND: Limited data describe the prognosis after stereotactic ablative radiotherapy for lung metastases arising from @entity2 . Thus, we evaluated treatment outcomes of stereotactic ablative radiotherapy for those @entity0 . METHODS: The study involved @entity0 received stereotactic ablative radiotherapy for one to three lung metastases arising from @entity2 at a single institution. A total dose of 40-60  Gy (median, 48  Gy) in three or four fractions was prescribed. RESULTS: A total of 79 metastatic lung lesions from 50 @entity0 who underwent curative resection for their primary @entity2 or salvage treatment at a recurrent site were included. The one- and three-year local control rates were 88.7  % and 70.6  %, respectively. The three-year overall survival and progression-free survival rates were 64.0  % and 24.0  %, respectively. @entity0 with @entity1 volume  <=1.5  mL had a significantly better overall survival rate than those with @entity1 volume >1.5  mL (68.0  % vs. 60.0  % at three-year, p   =   0.02). Local control was associated with a trend towards better survival (p   =   0.06). No @entity3 greater than grade 2 were observed. CONCLUSION: Stereotactic ablative radiotherapy is a competitive treatment modality for the management of lung metastases arising from @entity2 .

title: Clinical efficacy of stereotactic ablative radiotherapy for lung metastases arising from XXXX .

answer: @entity2