abstract: @entity1 ( @entity5 ) is prevalent in @entity2 and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant @entity5 on microbiota. Cirrhotic outpatients with/without @entity5 underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without @entity5 , and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% @entity3 ( @entity3 ), 31% @entity5 ] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and @entity3 without difference in @entity5 . Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p<   =   1.0e-02). Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and higher Enterococcaceae and Enterobacteriaceae were seen in hospitalized @entity0 . Concomitant @entity5 impacted microbiota UNIFRAC (stool, p   =   0.003, mucosa,p   =   0.04) with higher stool Bacteroidaceae and lower Ruminococcaeae. Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations independent of clinical predictors (MELD, @entity3 , PPI). Stool and @entity4 are altered in cirrhotics who get hospitalized with independent prediction using stool Bacteroidaceae and Clostridiales XIV. Concomitant @entity5 distinctly impacts gut microbiota without affecting hospitalizations.

title: Gut Microbiota Alterations can predict Hospitalizations in @entity2 Independent of XXXX .

answer: @entity1


abstract: @entity2 of the humeral condyle is exceptional in adults. The purpose was to analyze the results of surgical treatment by open reduction and internal fixation without ligamentous repair. There were six @entity0 with an average age of 31 years. According to the AO classification, five @entity2 were classified as AO type B1 and one as B2. Dislocation was reduced in emergency before osteosynthesis. Postoperatively, the joint was held immobile with a brace for 25.40 days. Five @entity0 were reviewed after a mean follow-up of 52.96 months. The median arc of flexion/extension was 104.80   and 157.8   for pronation-supination. All elbows were stable and all @entity2 were consolidated. Two elbows were @entity1 . The results were satisfactory in five @entity0 . The elbow stability can be ensured only by the synthesis of bone structures. Surgical treatment should restore exact anatomy between the condyle and trochlea. This protocol may provide a joint stability and satisfactory results.

title: XXXX of the humeral condyles in adults   : results of surgical treatment.

answer: @entity2


abstract: BACKGROUND: Endothelin-receptor-antagonist, @entity5 , has been found to improve the functional capacity and cardiopulmonary hemodynamics in @entity1 ( @entity1 ). Clinical trials have shown the preferable dosage of 125 mg, twice daily, regarding both efficacy and safety. OBJECTIVES: The purpose of this study was to investigate the effects of lower doses of @entity5 (62.5 mg, twice daily) in combination with @entity3 on exercise capacity and clinical events, in 41 @entity0 with @entity4 or @entity1 ( @entity1 ). @entity0 AND METHODS: We assigned 41 @entity0 with @entity1 (non-reactive idiopathic or non-operable chronic @entity2 ) to receive 62.5 mg of @entity5 twice daily as combination therapy and evaluated the New York heart association (NYHA) functional class, 6-minutes-walk-distance (6MWD), time to clinical worsening, echocardiographic indexes and clinical events, for an average of 18.5    9.5 months. RESULTS: No adverse drug reaction was observed during the follow-up. Clinical worsening occurred in six (14%) @entity0 , at least one year after treatment, two of the cases failed to respond to 125 mg, twice daily and died. Eight (19%) remained in FC I_II, but didn't reach the goal of 380 meters for 6MWD. All other @entity0 reached the treatment goals according to the latest European society of cardiology (ESC) guidelines. CONCLUSIONS: We observed acceptable results regarding both efficacy and safety with 62.5 mg of @entity5 , twice daily in this group of @entity0 . Further clinical trials investigating @entity1 with lower dosages of @entity5 may be warranted.

title: Lower Doses of @entity5 in Combination With @entity3 Might be XXXX .

answer: @entity1


abstract: BACKGROUND: Endothelin-receptor-antagonist, @entity5 , has been found to improve the functional capacity and cardiopulmonary hemodynamics in @entity1 ( @entity1 ). Clinical trials have shown the preferable dosage of 125 mg, twice daily, regarding both efficacy and safety. OBJECTIVES: The purpose of this study was to investigate the effects of lower doses of @entity5 (62.5 mg, twice daily) in combination with @entity3 on exercise capacity and clinical events, in 41 @entity0 with @entity4 or @entity1 ( @entity1 ). @entity0 AND METHODS: We assigned 41 @entity0 with @entity1 (non-reactive idiopathic or non-operable chronic @entity2 ) to receive 62.5 mg of @entity5 twice daily as combination therapy and evaluated the New York heart association (NYHA) functional class, 6-minutes-walk-distance (6MWD), time to clinical worsening, echocardiographic indexes and clinical events, for an average of 18.5    9.5 months. RESULTS: No adverse drug reaction was observed during the follow-up. Clinical worsening occurred in six (14%) @entity0 , at least one year after treatment, two of the cases failed to respond to 125 mg, twice daily and died. Eight (19%) remained in FC I_II, but didn't reach the goal of 380 meters for 6MWD. All other @entity0 reached the treatment goals according to the latest European society of cardiology (ESC) guidelines. CONCLUSIONS: We observed acceptable results regarding both efficacy and safety with 62.5 mg of @entity5 , twice daily in this group of @entity0 . Further clinical trials investigating @entity1 with lower dosages of @entity5 may be warranted.

title: Lower Doses of @entity5 in Combination With XXXX Might be @entity1 .

answer: @entity3


abstract: BACKGROUND: Endothelin-receptor-antagonist, @entity5 , has been found to improve the functional capacity and cardiopulmonary hemodynamics in @entity1 ( @entity1 ). Clinical trials have shown the preferable dosage of 125 mg, twice daily, regarding both efficacy and safety. OBJECTIVES: The purpose of this study was to investigate the effects of lower doses of @entity5 (62.5 mg, twice daily) in combination with @entity3 on exercise capacity and clinical events, in 41 @entity0 with @entity4 or @entity1 ( @entity1 ). @entity0 AND METHODS: We assigned 41 @entity0 with @entity1 (non-reactive idiopathic or non-operable chronic @entity2 ) to receive 62.5 mg of @entity5 twice daily as combination therapy and evaluated the New York heart association (NYHA) functional class, 6-minutes-walk-distance (6MWD), time to clinical worsening, echocardiographic indexes and clinical events, for an average of 18.5    9.5 months. RESULTS: No adverse drug reaction was observed during the follow-up. Clinical worsening occurred in six (14%) @entity0 , at least one year after treatment, two of the cases failed to respond to 125 mg, twice daily and died. Eight (19%) remained in FC I_II, but didn't reach the goal of 380 meters for 6MWD. All other @entity0 reached the treatment goals according to the latest European society of cardiology (ESC) guidelines. CONCLUSIONS: We observed acceptable results regarding both efficacy and safety with 62.5 mg of @entity5 , twice daily in this group of @entity0 . Further clinical trials investigating @entity1 with lower dosages of @entity5 may be warranted.

title: Lower Doses of XXXX in Combination With @entity3 Might be @entity1 .

answer: @entity5


abstract: Radiomics is being explored for potential applications in radiation therapy. How various imaging protocols affect quantitative image features is currently a highly active area of research. To assess the variability of image features derived from conventional [three-dimensional (3D)] and respiratory-gated (RG) positron emission tomography (PET)/computed tomography (CT) images of @entity1 @entity0 , image features were computed from 23 @entity1 @entity0 . Both protocols for each @entity0 were acquired during the same imaging session. PET @entity2 volumes were segmented using an adaptive technique which accounted for background. CT @entity2 volumes were delineated with a commercial segmentation tool. Using RG PET images, the @entity2 center of mass motion, length, and rotation were calculated. Fifty-six image features were extracted from all images consisting of shape descriptors, first-order features, and second-order texture features. Overall, 26.6% and 26.2% of total features demonstrated less than 5% difference between 3D and RG protocols for CT and PET, respectively. Between 10 RG phases in PET, 53.4% of features demonstrated percent differences less than 5%. The features with least variability for PET were sphericity, spherical disproportion, entropy (first and second order), sum entropy, information measure of correlation 2, Short Run Emphasis (SRE), Long Run Emphasis (LRE), and @entity3 ( @entity3 ); and those for CT were minimum intensity, mean intensity, Root Mean Square (RMS), Short Run Emphasis (SRE), and @entity3 . Quantitative analysis using a 3D acquisition versus RG acquisition (to reduce the effects of motion) provided notably different image feature values. This study suggests that the variability between 3D and RG features is mainly due to the impact of respiratory motion.

title: Variability of Image Features Computed from Conventional and Respiratory-Gated PET/CT Images of XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the influence of forward-facing @entity0 restraint systems' (FFCRSs) side impact structure, such as side wings, on the head kinematics and response of a restrained, far- or center-seated 3-year-old anthropomorphic test device (ATD) in oblique sled tests. METHODS: Sled tests were conducted utilizing an FFCRS with large side wings and with the side wings removed. The @entity1 were attached via LATCH on 2 different vehicle seat fixtures-a small SUV rear bench seat and minivan rear bucket seat-secured to the sled carriage at 20   from lateral. Four tests were conducted on each vehicle seat fixture, 2 for each FFCRS configuration. A Q3s dummy was positioned in FFCRS according to the @entity1 owner's manual and FMVSS 213 procedures. The tests were conducted using the proposed FMVSS 213 side impact pulse. Three-dimensional motion cameras collected head excursion data. Relevant data collected during testing included the ATD head excursions, head accelerations, LATCH belt loads, and neck loads. RESULTS: Results indicate that side wings have little influence on head excursions and ATD response. The median lateral head excursion was 435  mm with side wings and 443  mm without side wings. The primary differences in head response were observed between the 2 vehicle seat fixtures due to the vehicle seat head restraint design. The bench seat integrated head restraint forced a tether routing path over the head restraint. Due to the lateral crash forces, the tether moved laterally off the head restraint reducing tension and increasing head excursion (477  mm median). In contrast, when the tether was routed through the bucket seat's adjustable head restraint, it maintained a tight attachment and helped control head excursion (393  mm median). CONCLUSION: This testing illustrated relevant side impact crash circumstances where side wings do not provide the desired head containment for a 3-year-old ATD seated far-side or center in FFCRS. The head appears to roll out of the FFCRS even in the presence of side wings, which may expose the occupant to potential head impact injuries. We postulate that in a center or far-side seating configuration, the absence of door structure immediately adjacent to the @entity1 facilitates the rotation and tipping of the FFCRS toward the impact side and the roll-out of the head around the side wing structure. Results suggest that other prevention measures, in the form of alternative side impact structure design, FFCRS vehicle attachment, or shared protection between the FFCRS and the vehicle, may be necessary to protect @entity0 in oblique side impact crashes.

title: The Influence of Enhanced Side Impact Protection on Kinematics and Injury Measures of Far- or Center-Seated XXXX in Forward-Facing @entity0 Restraints.

answer: @entity0


abstract: OBJECTIVE: To evaluate the influence of forward-facing @entity0 restraint systems' (FFCRSs) side impact structure, such as side wings, on the head kinematics and response of a restrained, far- or center-seated 3-year-old anthropomorphic test device (ATD) in oblique sled tests. METHODS: Sled tests were conducted utilizing an FFCRS with large side wings and with the side wings removed. The @entity1 were attached via LATCH on 2 different vehicle seat fixtures-a small SUV rear bench seat and minivan rear bucket seat-secured to the sled carriage at 20   from lateral. Four tests were conducted on each vehicle seat fixture, 2 for each FFCRS configuration. A Q3s dummy was positioned in FFCRS according to the @entity1 owner's manual and FMVSS 213 procedures. The tests were conducted using the proposed FMVSS 213 side impact pulse. Three-dimensional motion cameras collected head excursion data. Relevant data collected during testing included the ATD head excursions, head accelerations, LATCH belt loads, and neck loads. RESULTS: Results indicate that side wings have little influence on head excursions and ATD response. The median lateral head excursion was 435  mm with side wings and 443  mm without side wings. The primary differences in head response were observed between the 2 vehicle seat fixtures due to the vehicle seat head restraint design. The bench seat integrated head restraint forced a tether routing path over the head restraint. Due to the lateral crash forces, the tether moved laterally off the head restraint reducing tension and increasing head excursion (477  mm median). In contrast, when the tether was routed through the bucket seat's adjustable head restraint, it maintained a tight attachment and helped control head excursion (393  mm median). CONCLUSION: This testing illustrated relevant side impact crash circumstances where side wings do not provide the desired head containment for a 3-year-old ATD seated far-side or center in FFCRS. The head appears to roll out of the FFCRS even in the presence of side wings, which may expose the occupant to potential head impact injuries. We postulate that in a center or far-side seating configuration, the absence of door structure immediately adjacent to the @entity1 facilitates the rotation and tipping of the FFCRS toward the impact side and the roll-out of the head around the side wing structure. Results suggest that other prevention measures, in the form of alternative side impact structure design, FFCRS vehicle attachment, or shared protection between the FFCRS and the vehicle, may be necessary to protect @entity0 in oblique side impact crashes.

title: The Influence of Enhanced Side Impact Protection on Kinematics and Injury Measures of Far- or Center-Seated @entity0 in Forward-Facing XXXX Restraints.

answer: @entity0


abstract: BACKGROUND: Despite strict avoidance, severely food-allergic @entity0 experience frequent and potentially severe food-induced @entity4 (FSFA). There are no accepted preventive interventions for FSFA. A @entity2 ( @entity2 ) formula prevents @entity4 in @entity1 @entity5 models, and has immunomodulatory effects in @entity0 . We analyzed the effects of @entity2 treatment on three pediatric @entity0 with FSFA. CASE DESCRIPTION: Three FSFA @entity0 (P) ages 9-16  years (P1 allergic to milk; P2 and P3 to tree nuts) qualified for case analysis. All experienced numerous reactions requiring administration of rescue medications and emergency room (ER) visits during the 2  years prior to starting @entity2 . P1 experienced approximately 100 reactions, 50 @entity3 administrations, 40 ER visits, and 3 admissions to intensive care units. P2 experienced 30 reactions, all requiring @entity3 administration, as well as 10 emergency hospitalizations. P3 experienced 400 reactions, five of which required @entity3 administration and ER visits. @entity2 treatment markedly reduced or eliminated reactions in all. P1 experienced no reactions after 2.5 years of @entity2 . P2 experienced no reactions after 1  year of @entity2 treatment, at which time she passed an oral almond food challenge. She continues to be reaction-free 6  months off @entity2 while consuming nuts. P3 has achieved a 94% reduction in reaction frequency following 7  months of @entity2 , has discontinued daily @entity6 use, and has required no @entity3 administrations or ER visits. CONCLUSIONS: Three @entity0 treated with @entity2 experienced dramatic reductions or elimination of FSFA. This regimen appears to present a potential option for FSFA, and warrants further investigation in controlled clinical studies.

title: Successful prevention of extremely frequent and severe XXXX in three @entity0 by combined traditional Chinese medicine therapy.

answer: @entity4


abstract: BACKGROUND: Despite strict avoidance, severely food-allergic @entity0 experience frequent and potentially severe food-induced @entity4 (FSFA). There are no accepted preventive interventions for FSFA. A @entity2 ( @entity2 ) formula prevents @entity4 in @entity1 @entity5 models, and has immunomodulatory effects in @entity0 . We analyzed the effects of @entity2 treatment on three pediatric @entity0 with FSFA. CASE DESCRIPTION: Three FSFA @entity0 (P) ages 9-16  years (P1 allergic to milk; P2 and P3 to tree nuts) qualified for case analysis. All experienced numerous reactions requiring administration of rescue medications and emergency room (ER) visits during the 2  years prior to starting @entity2 . P1 experienced approximately 100 reactions, 50 @entity3 administrations, 40 ER visits, and 3 admissions to intensive care units. P2 experienced 30 reactions, all requiring @entity3 administration, as well as 10 emergency hospitalizations. P3 experienced 400 reactions, five of which required @entity3 administration and ER visits. @entity2 treatment markedly reduced or eliminated reactions in all. P1 experienced no reactions after 2.5 years of @entity2 . P2 experienced no reactions after 1  year of @entity2 treatment, at which time she passed an oral almond food challenge. She continues to be reaction-free 6  months off @entity2 while consuming nuts. P3 has achieved a 94% reduction in reaction frequency following 7  months of @entity2 , has discontinued daily @entity6 use, and has required no @entity3 administrations or ER visits. CONCLUSIONS: Three @entity0 treated with @entity2 experienced dramatic reductions or elimination of FSFA. This regimen appears to present a potential option for FSFA, and warrants further investigation in controlled clinical studies.

title: Successful prevention of extremely frequent and severe @entity4 in three XXXX by combined traditional Chinese medicine therapy.

answer: @entity0


abstract: OBJECTIVE: This article investigates subjects aged 55 to 65 from the @entity1 Neuroimaging Initiative (ADNI) database to broaden our understanding of early-onset (EO) @entity0 using neuroimaging and genetics biomarkers. METHODS: Nine of the subjects had EO-AD ( @entity1 ) and 27 had EO-MCI (mild @entity0 ). The 15 most important neuroimaging markers were extracted with the Global Shape Analysis (GSA) Pipeline workflow. The 20 most significant single nucleotide polymorphisms (SNPs) were chosen and were associated with specific neuroimaging biomarkers. RESULTS: We identified associations between the neuroimaging phenotypes and genotypes for a total of 36 subjects. Our results for all the subjects taken together showed the most significant associations between @entity2 and L_hippocampus (volume), and between @entity2 and R_hippocampus (volume). For the 27 MCI subjects, we found the most significant associations between @entity3 and R_superior_frontal_gyrus (volume), and between @entity4 and L_Precuneus (volume). For the nine AD subjects, we found the most significant associations between @entity5 and L_rectus gyrus (surface area), and between @entity6 and L_rectus_gyrus (surface area). CONCLUSION: We observed significant correlations between the SNPs and the neuroimaging phenotypes in the 36 EO subjects in terms of neuroimaging genetics. However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.

title: Gene interactions and structural brain change in early-onset XXXX subjects using the pipeline environment.

answer: @entity1


abstract: INTRODUCTION: Our goal was to explore whether @entity3 ( @entity3 ) @entity0 would disclose their sexual orientation in a research evaluation and to examine demographic and clinical characteristics of @entity0 by self-identified sexual orientation. METHODS: @entity0 (n=177) presented for @entity2 treatment at three urban EDs in New York City, Rochester, NY, and Philadelphia, PA. @entity0 were interviewed in the context of a larger study of a standardized suicide risk assessment. We assessed @entity0 ' willingness to answer questions regarding sexual orientation along three dimensions: a self-description of sexual orientation, a self-description of sexual attraction, and the gender of any prior sexual partners. RESULTS: No @entity0 (0/177) refused to respond to the categorical question about sexual orientation, 168/177 (94.9%) agreed to provide information about prior sexual partners, and 100/109 (91.7%) provided information about current sexual attraction toward either gender. Of all 177 @entity0 , 154 (87.0%) self-identified as heterosexual, 11 (6.2%) as bisexual, 10 (5.6%) as gay or lesbian, and 2 (1.1%) indicated they were not sure. As compared with heterosexual @entity0 , lesbian, gay and bisexual (LGB) @entity0 were significantly younger and more likely to be non-white, but did not differ significantly in terms of education, income, employment, or religious affiliation or participation. Further, LGB @entity0 did not differ from self-identified heterosexual @entity0 for lifetime suicide attempt rate or lifetime history of any mood, substance-related, @entity4 spectrum, or other Diagnostic and Statistical Manual of @entity2 , 4th edition (DSM-IV) @entity1 . Of self-identified heterosexual @entity0 5.6% (5/89) reported sexual attraction as other than 'only opposite sex,' and 10.3% (15/142) of sexually active 'heterosexual' @entity0 reported previous same-gender sexual partners. CONCLUSION: Assessing @entity0 ' sexual orientation in the @entity3 by a three-question approach appeared feasible in the @entity3 and acceptable to @entity3 @entity0 . However, since many @entity0 have sexual experiences not suggested by simple labels, self-report of sexual identity alone may not inform clinicians of health risks inherent in same or opposite gender sexual contact.

title: Screening for sexual orientation in XXXX emergency departments.

answer: @entity2


abstract: INTRODUCTION: Studies have demonstrated that variables other than duration of symptoms can affect outcomes in @entity0 with acute @entity2 . We examined demographic and logistical factors, including inter-hospital transfer, which may affect outcomes at a tertiary pediatric referral center. METHODS: We reviewed charts of all pediatric @entity0 with acute @entity2 during a five-year period. Data were collected regarding age, insurance type, socioeconomic status, duration of symptoms prior to presentation, transfer status, time of day, time to surgical exploration, and testicular salvage. RESULTS: Our study included 114 @entity0 . Testicular salvage was possible in 55.3% of @entity0 . Thirty-one percent of @entity0 included in the study were transferred from another facility. Inter-hospital transfer did not affect testicular salvage rate. Time to surgery and duration of @entity1 were higher among @entity0 who underwent orchiectomy versus orchidopexy. @entity0 older than eight years of age were more likely to undergo orchidopexy than those younger than eight (61.5% vs. 30.4%, p=0.01). Ethnicity, insurance type, or time of day did not affect the testicular salvage rates. On multivariate analysis, only duration of symptoms less than six hours predicted testicular salvage (OR 22.5, p<0.001). CONCLUSION: Even though inter-hospital transfer delays definitive surgical management, it may not affect testicular salvage rates. Time to presentation is the most important factor in predicting outcomes in @entity0 with acute @entity2 .

title: Factors influencing rate of testicular salvage in acute XXXX at a tertiary pediatric center.

answer: @entity2


abstract: PURPOSE: Little is known about the potential role of lifestyle factors in sex differences in insulin resistance in late elementary school @entity0 . METHODS: In this cross-sectional study, we compared sex differences in Tanner scales, body fat, physical activity (PA) and fitness, and insulin resistance markers in elementary school @entity0 ( @entity0 , n = 69 and @entity0 , n = 81) aged 12-13 years. Body composition was assessed with a standardized protocol. @entity3 was measured as @entity1 consumption during an incremental treadmill exercise. Fasting blood samples were collected for blood chemistry assays including lipids, @entity4 , insulin and homeostasis model assessment for insulin resistance (HOMA-IR), leptin, and @entity5 . Daily PA was measured with an accelerometer for 7 consecutive days, and they were classified as low-, moderate-, and vigorous-PA. Independent t-tests were used to compare mean differences in the measured variables between @entity0 and @entity0 . There were significant sex differences in Tanner scales, body mass index, percent body fat, and waist circumference (WC). RESULTS: @entity0 had significantly higher values in Tanner scales (p < 0.001) and percent body fat (p < 0.001) than @entity0 . @entity0 had significantly higher values in body mass index (p = 0.019) and waist circumference (p < 0.001) than @entity0 . @entity0 also had significantly higher values in VO2max (p < 0.001) and low (p < 0.001), moderate (p < 0.001), and vigorous (p < 0.001) PAs. With respect to metabolic risk factors, @entity0 had significantly higher serum levels of @entity6 (p = 0.005), insulin (p < 0.001), and HOMA-IR (p < 0.001) and significantly lower high-density lipoprotein @entity2 (p = 0.015) than @entity0 . CONCLUSION: In summary, the current findings of the study showed that the increased risk for insulin resistance in @entity0 over @entity0 is associated with higher Tanner scale and percent body fat in conjunction with poor @entity3 and physical inactivity, suggesting that exercise intervention to promote physical activity and fitness is imperative for general health promotion of school @entity0 , with a special focus on @entity0 .

title: Roles of physical activity and XXXX on sex difference in insulin resistance in late elementary years.

answer: @entity3


abstract: PURPOSE: To evaluate the long-term visual outcomes and complications of the piggyback intraocular lens (IOL) implantation compared to @entity4 for infantile @entity1 . @entity0 AND METHODS: In a comparative study from 1998 to 2007, @entity3 (piggyback IOL group) was performed for 14 @entity0 (23 eyes) with infantile @entity1 and 20 @entity0 (32 eyes) who were aphakic ( @entity4 group) after infantile @entity1 surgery. Data were collected on logMAR visual acuity, and @entity2 over a mean follow-up time of 6.2    1.7 years and 5.8    1.7 years. RESULTS: The mean age at surgery was 7.5    0.6 months and 6.0    3.3 months for the piggyback and the aphakic group respectively (P > 0.05). At the last follow-up visit, visual acuity was 0.85    0.73 (median = 0.70, interquartile range = 0.3-1.32) in the piggyback IOL group and 0.89    0.56 (median = 0.86, interquartile range = 0.50-1.24) in the aphakic group (P > 0.05). There was a positive relationship between age and visual outcomes in the aphakic group (r = 0.4, P = 0.04) but not in the piggyback IOL group (P = 0.48). There was no significant difference between the mean myopic shift in the piggyback IOL group (  -5.28    1.06 D) and the aphakic group (  -5.10    1.02 D) (P > 0.05). The incidence of reoperation due to complications in piggyback IOL group was higher than aphakic group (%48 vs. %16, respectively, P  <= 0.01). However, in @entity0 older than 6 months, this risk was not significantly different compared to the aphakic group. CONCLUSIONS: Although @entity3 for infantile @entity1 is optically acceptable as a treatment option, there is no significant difference in visual outcomes compared to @entity4 . The incidence in reoperation due to complications in @entity0 aged 6 months or younger is higher than those treated with @entity4 .

title: Visual Outcomes and Complications of Piggyback Intraocular Lens Implantation Compared to @entity4 for Infantile XXXX .

answer: @entity1


abstract: PURPOSE: To evaluate the long-term visual outcomes and complications of the piggyback intraocular lens (IOL) implantation compared to @entity4 for infantile @entity1 . @entity0 AND METHODS: In a comparative study from 1998 to 2007, @entity3 (piggyback IOL group) was performed for 14 @entity0 (23 eyes) with infantile @entity1 and 20 @entity0 (32 eyes) who were aphakic ( @entity4 group) after infantile @entity1 surgery. Data were collected on logMAR visual acuity, and @entity2 over a mean follow-up time of 6.2    1.7 years and 5.8    1.7 years. RESULTS: The mean age at surgery was 7.5    0.6 months and 6.0    3.3 months for the piggyback and the aphakic group respectively (P > 0.05). At the last follow-up visit, visual acuity was 0.85    0.73 (median = 0.70, interquartile range = 0.3-1.32) in the piggyback IOL group and 0.89    0.56 (median = 0.86, interquartile range = 0.50-1.24) in the aphakic group (P > 0.05). There was a positive relationship between age and visual outcomes in the aphakic group (r = 0.4, P = 0.04) but not in the piggyback IOL group (P = 0.48). There was no significant difference between the mean myopic shift in the piggyback IOL group (  -5.28    1.06 D) and the aphakic group (  -5.10    1.02 D) (P > 0.05). The incidence of reoperation due to complications in piggyback IOL group was higher than aphakic group (%48 vs. %16, respectively, P  <= 0.01). However, in @entity0 older than 6 months, this risk was not significantly different compared to the aphakic group. CONCLUSIONS: Although @entity3 for infantile @entity1 is optically acceptable as a treatment option, there is no significant difference in visual outcomes compared to @entity4 . The incidence in reoperation due to complications in @entity0 aged 6 months or younger is higher than those treated with @entity4 .

title: Visual Outcomes and Complications of Piggyback Intraocular Lens Implantation Compared to XXXX for Infantile @entity1 .

answer: @entity4


abstract: @entity6 , also known as 46 XY pure @entity2 , is a rare @entity5 . Affected individuals are phenotypically female with female genitalia, normal Mullerian structures, absent testicular tissue, and a 46 XY chromosomal constitution. We report a series of eight cases of @entity6 , of which six were managed by laparoscopic gonadectomy. The two other cases had to undergo an exploratory laparotomy in view of their presentation with @entity4 . Two of the @entity0 were siblings. The chief presenting complaint was primary @entity3 . Four @entity0 also presented with a history of poor development of secondary sexual characters. The average age at presentation was 16.19  2.85 years. The average height was 158.33   4.63 cm, and the average weight was 49.33  8.44 kg. Breast development was either Tanner 2 or 3 in four @entity0 , whereas three @entity0 had a Tanner 1 underdeveloped breasts. Axillary and pelvic hair was sparse in all the @entity0 . The vagina was well canalized in all the @entity0 . Hormonal evaluation revealed @entity8 with a mean follicle-stimulating hormone (FSH) level of 95.81 mIU/L and a mean luteinizing (LH) level of 24.15 mIU/L. Imaging analysis revealed the presence of a small uterus in all the cases, except one. Bilateral ovaries were either not visualized or streak gonads were present. @entity4 was detected in two of the six cases with raised carcinoembryonic antigen (CA) 125 levels in one case. Genetic analysis revealed a karyotype of 46 XY in six @entity0 , 46 XY/45 X in one, and the culture repeatedly failed in one @entity0 . Because of the risk of @entity1 , bilateral gonadectomy was performed in all cases. Histopathological analysis revealed that three of the six cases had @entity7 . The @entity0 have been started on hormone replacement therapy. Laparoscopy is a minimally invasive modality for the definitive diagnosis and treatment of cases with @entity6 . An early diagnosis of @entity6 is possible during workup for primary @entity3 before they present with @entity4 .

title: The laparoscopic management of XXXX : Case series.

answer: @entity6


abstract: OBJECTIVES: @entity3 in @entity1 ( @entity1 ) can manifest higher range of motions in mandible. The aim of this study was to compare the position and distances of the head of condyle to glenoid fossa in TMJs of healthy individuals and @entity0 with mild, moderate and severe @entity1 @entity3 . MATERIAL AND METHODS: In this clinical study, 69 @entity0 (between the ages of 22 to 42) with manifestation of joint @entity3 were included and Computed tomography were administered for both TMJs. The @entity0 were divided into three groups based on their maximum mouth opening (MMO): (A) with MMO of 50-55 mm; (B) with MMO between 55 to 65 mm; and (C) with MMO >65 mm. Also, 15 healthy @entity0 with profiled tomography in the last 6 months were assumed as control group (N) with normal MMO (<50 mm). The position of condyle from articular eminence while MMO; and the distances from anterior, superior and posterior border of condyle and facing wall of glenoid fossa were measured in closed mouth from the tomography of all contributors. The collected data were analyzed by one-way ANOVA, Post Hoc and Chi-Square tests using SPSS software version 15 at significant level of 0.05. RESULTS: The superior and posterior distances were significantly higher in groups A, B and C than healthy individuals (all P values<0.01). The anterior distance was significant between groups B and N only in right @entity1 (P=0.013). CONCLUSIONS: @entity1 @entity3 showed the characteristic of increased condylar distance in posterior and superior specially in higher @entity2 . Key words:Computed tomography, joint @entity3 , mandibular condyle, mouth opening.

title: Condylar distances in hypermobile temporomandibular joints of @entity0 with XXXX by using computed tomography.

answer: @entity2


abstract: OBJECTIVES: @entity3 in @entity1 ( @entity1 ) can manifest higher range of motions in mandible. The aim of this study was to compare the position and distances of the head of condyle to glenoid fossa in TMJs of healthy individuals and @entity0 with mild, moderate and severe @entity1 @entity3 . MATERIAL AND METHODS: In this clinical study, 69 @entity0 (between the ages of 22 to 42) with manifestation of joint @entity3 were included and Computed tomography were administered for both TMJs. The @entity0 were divided into three groups based on their maximum mouth opening (MMO): (A) with MMO of 50-55 mm; (B) with MMO between 55 to 65 mm; and (C) with MMO >65 mm. Also, 15 healthy @entity0 with profiled tomography in the last 6 months were assumed as control group (N) with normal MMO (<50 mm). The position of condyle from articular eminence while MMO; and the distances from anterior, superior and posterior border of condyle and facing wall of glenoid fossa were measured in closed mouth from the tomography of all contributors. The collected data were analyzed by one-way ANOVA, Post Hoc and Chi-Square tests using SPSS software version 15 at significant level of 0.05. RESULTS: The superior and posterior distances were significantly higher in groups A, B and C than healthy individuals (all P values<0.01). The anterior distance was significant between groups B and N only in right @entity1 (P=0.013). CONCLUSIONS: @entity1 @entity3 showed the characteristic of increased condylar distance in posterior and superior specially in higher @entity2 . Key words:Computed tomography, joint @entity3 , mandibular condyle, mouth opening.

title: Condylar distances in hypermobile temporomandibular joints of XXXX with @entity2 by using computed tomography.

answer: @entity0


abstract: OBJECTIVE: The cervicothoracic junction (CTJ) is a biomechanically and anatomically complex region that has traditionally posed problems for surgical access. In this retrospective study, we describe our clinical experiences of the treatment of metastatic @entity1 at the CTJ and the results. METHODS: From June 2006 to December 2011, 23 @entity0 who underwent surgery for @entity1 involving the CTJ were enrolled in our study. All of the @entity0 were operated on through the posterior approach, and extent of resection was classified as radical, debulking, and simple neural decompression. Adjuvant @entity3 ( @entity3 ) was also considered. Visual analog scale score for @entity2 assessment and Medical Research Council (MRC) grade for motor weakness were used, while pre- and post-operative performance status was evaluated using the Eastern Cooperative Oncology Group (ECOG). RESULTS: Almost all of the @entity0 were operated using palliative surgical methods (91.3%, 21/23). Ten complications following surgery occurred and revision was performed in four @entity0 . Of the 23 @entity0 of this study, 22 showed significant @entity2 relief according to their visual analogue scale scores. Concerning the aspect of neurological and functional recovery, mean MRC grade and ECOG score was significantly improved after surgery (p<0.05). In terms of survival, @entity3 had a significant role. Median overall survival was 124 days after surgery, and the adjuvant- @entity3 group (median 214 days) had longer survival times than prior- @entity3 (63 days) group. CONCLUSION: Although surgical procedure in CTJ may be difficult, we expect good clinical results by adopting a palliative posterior surgical method with appropriate preoperative preparation and postoperative treatment.

title: Surgical management with XXXX for metastatic @entity1 located on cervicothoracic junction : a single center study.

answer: @entity3


abstract: OBJECTIVE: The cervicothoracic junction (CTJ) is a biomechanically and anatomically complex region that has traditionally posed problems for surgical access. In this retrospective study, we describe our clinical experiences of the treatment of metastatic @entity1 at the CTJ and the results. METHODS: From June 2006 to December 2011, 23 @entity0 who underwent surgery for @entity1 involving the CTJ were enrolled in our study. All of the @entity0 were operated on through the posterior approach, and extent of resection was classified as radical, debulking, and simple neural decompression. Adjuvant @entity3 ( @entity3 ) was also considered. Visual analog scale score for @entity2 assessment and Medical Research Council (MRC) grade for motor weakness were used, while pre- and post-operative performance status was evaluated using the Eastern Cooperative Oncology Group (ECOG). RESULTS: Almost all of the @entity0 were operated using palliative surgical methods (91.3%, 21/23). Ten complications following surgery occurred and revision was performed in four @entity0 . Of the 23 @entity0 of this study, 22 showed significant @entity2 relief according to their visual analogue scale scores. Concerning the aspect of neurological and functional recovery, mean MRC grade and ECOG score was significantly improved after surgery (p<0.05). In terms of survival, @entity3 had a significant role. Median overall survival was 124 days after surgery, and the adjuvant- @entity3 group (median 214 days) had longer survival times than prior- @entity3 (63 days) group. CONCLUSION: Although surgical procedure in CTJ may be difficult, we expect good clinical results by adopting a palliative posterior surgical method with appropriate preoperative preparation and postoperative treatment.

title: Surgical management with @entity3 for metastatic XXXX located on cervicothoracic junction : a single center study.

answer: @entity1


abstract: BACKGROUND: @entity3 infects 10,000 to 30,000 international travellers each year.  It can be prevented through anti-mosquito measures and drug prophylaxis.  However, antimalaria drugs have adverse effects which are sometimes serious. OBJECTIVES: To compare the effects of currently used antimalaria drugs when given as prophylaxis to non-immune adult and @entity0 travellers who are travelling to regions with @entity6 resistance to @entity4 . Specifically, to assess the efficacy, safety, and tolerability of @entity9 - @entity10 , @entity5 , and @entity7 compared to each other, and also when compared to @entity4 - @entity10 and to @entity8 . SEARCH METHODS: In August 2009 we searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (The Cochrane Library 2008, Issue 4), MEDLINE, EMBASE, LILACS, BIOSIS, mRCT, and reference lists. We handsearched conference proceedings and one specialist journal, and contacted researchers and drug companies. We searched PubMed for drug-related @entity2 . SELECTION CRITERIA: Randomized and quasi-randomized controlled trials of any antimalaria drug regimen currently used by non-immune international travellers. DATA COLLECTION AND ANALYSIS: We independently extracted data and assessed eligibility and risk of bias using a standardized data collection form. We resolved any disagreement through discussion. We combined dichotomous outcomes using risk ratio (RR) and continuous data using mean difference (MD), presenting both with 95% confidence intervals (CI). MAIN RESULTS: Eight trials (4240 @entity0 ) met the inclusion criteria. Evidence on comparative efficacy from head-to-head comparisons was limited. @entity9 - @entity10 compared to @entity5 had similar adverse events reported. Compared to @entity7 , @entity9 - @entity10 users had fewer reports of any adverse effect (RR 0.72, 95% CI 0.6 to 0.85), gastrointestinal adverse effects (RR 0.54, 95% CI 0.42 to 0.7), @entity1 adverse events (RR 0.86, 95% CI 0.75 to 0.99), and @entity1 adverse effects (RR 0.49, 95% CI 0.38 to 0.63), besides a better total mood disturbance score (MD -7.20, 95% CI -10.79 to -3.61). Similarly, @entity5 users had fewer reported @entity1 events than @entity7 users (RR 0.84, 95% CI 0.73 to 0.96). We also examined these three regimens against @entity4 - @entity10 ; this latter regimen had more reports of any adverse effect (RR 0.84, 95% CI 0.73 to 0.96) and of gastrointestinal adverse effects (RR 0.71, 95% CI 0.6 to 0.85). AUTHORS' CONCLUSIONS: @entity9 - @entity10 and @entity5 are the best tolerated regimens, and @entity7 is associated with adverse @entity1 outcomes.

title: WITHDRAWN: Drugs for preventing XXXX in travellers.

answer: @entity3


abstract: Dermatophytes are among the common fungal agents implicated in superficial @entity1 worldwide. They include species of @entity3 , Microsporum and Epidermophyton. In hot and humid climates of tropical and subtropical regions, the incidence of these pathogens is higher. We present in this article, the epidemiological data regarding the prevalence of different dermatophyte species involved in superficial mycoses in @entity0 @entity0 in the state of Himachal Pradesh (India) and different clinical conditions, age and sex of the @entity0 . A total of 202 samples in the form of skin and nail scrapings, hair follicles were collected from different ringworm/ @entity2 conditions which included: @entity2 , T. capitis, T. cruris, T. pedis, T. unguium, T. faciei, T. manuum and T. gladiatorum. On culturing, 74 samples (36.6%) were found positive for dermatophyte spp. @entity3 spp. was the predominant one (98.65% cases) followed by @entity4 (1.35% cases). However, we did not recover any Epidermophyton spp. Among the @entity3 spp., T. mentegrophyte was the predominant spp. (63.5%) followed by @entity3 (35.1%). The male to female ratio of the positive cases was recorded as 63:11. The most effected age group was 21-50  years (64.9%) followed by 1-20  years (28.4%) and above 50  years (6.8%).

title: Epidemiological studies on XXXX in @entity0 @entity0 in Himachal Pradesh, India.

answer: @entity2


abstract: Dermatophytes are among the common fungal agents implicated in superficial @entity1 worldwide. They include species of @entity3 , Microsporum and Epidermophyton. In hot and humid climates of tropical and subtropical regions, the incidence of these pathogens is higher. We present in this article, the epidemiological data regarding the prevalence of different dermatophyte species involved in superficial mycoses in @entity0 @entity0 in the state of Himachal Pradesh (India) and different clinical conditions, age and sex of the @entity0 . A total of 202 samples in the form of skin and nail scrapings, hair follicles were collected from different ringworm/ @entity2 conditions which included: @entity2 , T. capitis, T. cruris, T. pedis, T. unguium, T. faciei, T. manuum and T. gladiatorum. On culturing, 74 samples (36.6%) were found positive for dermatophyte spp. @entity3 spp. was the predominant one (98.65% cases) followed by @entity4 (1.35% cases). However, we did not recover any Epidermophyton spp. Among the @entity3 spp., T. mentegrophyte was the predominant spp. (63.5%) followed by @entity3 (35.1%). The male to female ratio of the positive cases was recorded as 63:11. The most effected age group was 21-50  years (64.9%) followed by 1-20  years (28.4%) and above 50  years (6.8%).

title: Epidemiological studies on @entity2 in XXXX @entity0 in Himachal Pradesh, India.

answer: @entity0


abstract: Dermatophytes are among the common fungal agents implicated in superficial @entity1 worldwide. They include species of @entity3 , Microsporum and Epidermophyton. In hot and humid climates of tropical and subtropical regions, the incidence of these pathogens is higher. We present in this article, the epidemiological data regarding the prevalence of different dermatophyte species involved in superficial mycoses in @entity0 @entity0 in the state of Himachal Pradesh (India) and different clinical conditions, age and sex of the @entity0 . A total of 202 samples in the form of skin and nail scrapings, hair follicles were collected from different ringworm/ @entity2 conditions which included: @entity2 , T. capitis, T. cruris, T. pedis, T. unguium, T. faciei, T. manuum and T. gladiatorum. On culturing, 74 samples (36.6%) were found positive for dermatophyte spp. @entity3 spp. was the predominant one (98.65% cases) followed by @entity4 (1.35% cases). However, we did not recover any Epidermophyton spp. Among the @entity3 spp., T. mentegrophyte was the predominant spp. (63.5%) followed by @entity3 (35.1%). The male to female ratio of the positive cases was recorded as 63:11. The most effected age group was 21-50  years (64.9%) followed by 1-20  years (28.4%) and above 50  years (6.8%).

title: Epidemiological studies on @entity2 in @entity0 XXXX in Himachal Pradesh, India.

answer: @entity0


abstract: Single fraction radiosurgery is conventionally precluded for lesions lying <2-3  mm of the anterior visual pathway because of the radiosensitivity of the optic nerve. We analyzed a series of 64 @entity0 with "perioptic" @entity3 treated by CyberKnife multisession radiosurgery and hypofractionated stereotactic radiotherapy (hSRT). Between July 2007-May 2010, @entity0 were treated using conventional multisession Cyberknife schemes (2-5 fractions) and results were retrospectively analyzed. A radiobiological model was then developed to estimate the best @entity1 ( @entity1 )/ normal tissue complication probability (NTCP) for these lesions. Resulting dose/fraction schemes were applied to @entity0 treated between May 2010 and July 2014. Data were prospectively collected Twenty-five @entity0 were included in the retrospective part of the study. Median @entity1 volume was 4.95  cc; median dose was 23.0  Gy and median number of fraction was 5 (range 2-5). No @entity0 had @entity2 at mean follow-up of 60        12  months. Tumor control was achieved in all cases. Thirty-nine @entity0 were treated according the radiobiology model and results prospectively analyzed. Median @entity1 volume was 7.5  cc, median dose 25.0  Gy and mean number of fraction 5 (range 3-15). No @entity0 had @entity2 progression at mean follow-up of 17        10  months. Conventional multisession CyberKnife treatments (2-5 fractions) provided satisfactory results. Nonetheless, our estimation of @entity1 suggests the use of higher doses to grant long-term disease control. To achieve higher equivalent doses without significantly increasing the NTCP, we suggest the use of a greater number of fractions, moving to hSRT, in @entity1 in which the encasement of optic nerves is presumed.

title: CyberKnife multisession stereotactic radiosurgery and hypofractionated stereotactic radiotherapy for perioptic XXXX : intermediate-term results and radiobiological considerations.

answer: @entity3


abstract: BACKGROUND/AIMS: Endoscopic @entity1 (EPBD) has been advocated as an alternative therapy to endoscopic sphincterotomy for the treatment of common bile duct (CBD) stones. However, there is no established consensus on the optimal @entity1 ( @entity1 ). We prospectively evaluated the efficacy and post-endoscopic retrograde cholangiopancreatography (ERCP) complications between the 20- and 60-second EPBD groups. METHODS: A total of 228 @entity0 with small CBD stones ( <=12 mm) were randomly assigned to undergo EPBD with a 20- or 60-second duration at six institutions. We evaluated baseline @entity0 characteristics, endoscopic data, clinical outcomes, and procedure-related complications. In addition, we analyzed risk factors for postprocedural @entity2 . RESULTS: CBD stones were removed successfully in 107 of 109 @entity0 (98.1%) in the 20-second group and in 112 of 119 @entity0 (94.1%) in the 60-second group (p=0.146). Post-ERCP @entity2 developed in seven @entity0 (6.4%) in the 20-second group and nine @entity0 (7.5%) in the 60-second group (p=0.408). In multivariate analysis, contrast dye injection into the pancreatic duct is a significant risk factor for post-EPBD @entity2 . CONCLUSIONS: Based on the data showing that there were no significant differences in safety and efficacy between the two @entity1 groups, 20 seconds of @entity1 may be adequate for treatment of small CBD stones with EPBD.

title: Twenty-Second versus Sixty-Second Dilation Duration in Endoscopic XXXX for the Treatment of Small Common Bile Duct Stones: A Prospective Randomized Controlled Multicenter Trial.

answer: @entity1


abstract: Protein synthesis is a fundamental process to gene expression impacting diverse biological processes notably adaptation to environmental conditions. The initiation step, which involves the assembly of the ribosomal subunits at the mRNA initiation codon, involved initiation factor including @entity5 . Defects in this rate limiting step of translation are linked to diverse disorders. To study the potential consequences of such deregulations, @entity3 oocytes constitute an attractive model with high degrees of conservation of essential cellular and molecular mechanisms with @entity0 . In addition, during meiotic maturation, oocytes are transcriptionally repressed and all necessary proteins are translated from preexisting, maternally derived mRNAs. This inexpensive model enables exogenous mRNA to become perfectly integrated with an effective translation. Here is described a protocol for assessing translation with a factor of interest (here @entity5 ) using stored maternal mRNA that are the first to be polyadenylated and translated during oocyte maturation as a physiological readout. At first, mRNA synthetized by in vitro transcription of plasmids of interest (here @entity5 ) are injected in oocytes and kinetics of oocyte maturation by Germinal Vesicle Breakdown detection is determined. The studied maternal mRNA target is the @entity2 / @entity4 -protein-kinase mos. Its polyadenylation and its subsequent translation are investigated together with the expression and phosphorylation of proteins of the mos signaling cascade involved in oocyte maturation. Variations of the current protocol to put forward translational defects are also proposed to emphasize its general applicability. In light of emerging evidence that aberrant protein synthesis may be involved in the pathogenesis of @entity1 , such a model provides the opportunity to easily assess this impairment and identify new targets.

title: XXXX as a Model to Identify Translation Impairment.

answer: @entity3


abstract: Vascular involvement is one of the major causes of mortality and morbidity in @entity1 ( @entity1 ). There are no controlled studies for the management of @entity3 ( @entity3 ), and according to the EULAR recommendations, only immunosuppressive (IS) agents are recommended. In this study, we aimed to investigate the therapeutic approaches chosen by Turkish physicians during the initial event and relapses of @entity3 and the association of different treatment options with the relapses retrospectively. @entity0 with @entity1 (n=936, female/male: 347/589, mean age: 37.6  10.8) classified according to ISG criteria from 15 rheumatology centers in @entity2 were included. The demographic data, clinical characteristics of the first vascular event and relapses, treatment protocols, and data about complications were acquired. @entity3 was observed in 27.7% (n=260) of the @entity0 during follow-up. In 57.3% of the @entity3 @entity0 , vascular involvement was the presenting sign of the disease. After the first vascular event, ISs were given to 88.8% and AC treatment to 59.8% of the @entity0 . Median duration of AC treatment was 13 months (1-204) and ISs, 22 months (1-204). @entity4 related to AC treatment was observed in 7 (4.7%) @entity0 . A second vascular event developed in 32.9% (n=86) of the @entity0 . The vascular relapse rate was similar between @entity0 taking only ISs and AC plus IS treatments after the first vascular event (29.1% vs 22.4%, P=0.28) and was significantly higher in group taking only ACs than taking only ISs (91.6% vs 29.1%, P<0.001). During follow-up, a third vascular event developed in 17 (n=6.5%) @entity0 . The relapse rate was also similar between the @entity0 taking only ISs and AC plus IS treatments after second vascular event (25.3% vs 20.8%, P=0.93). When multivariate analysis was performed, development of vascular relapse negatively correlated with only IS treatments.We did not find any additional positive effect of AC treatment used in combination with ISs in the course of vascular involvement in @entity0 with @entity1 . Severe complications related to AC treatment were also not detected. Our results suggest that short duration of IS treatments and compliance issues of treatment are the major problems in @entity3 associated with vascular relapses during follow-up.

title: XXXX with vascular involvement: effects of different therapeutic regimens on the incidence of new relapses.

answer: @entity1


abstract: UNASSIGNED: Targeted molecular therapy is an effective anticancer strategy. Anti-EGFR monoclonal antibodies such as cetuximab (CTX) have been approved for the treatment of various @entity1 , including @entity2 ( @entity2 ) with wild-type @entity6 . However, their efficacy in @entity0 with @entity6 mutations has not been established. Therefore, we investigated whether CTX treatment was effective as a single agent or in combination with @entity7 ( @entity8 ) in @entity0 @entity2 cell lines with different @entity6 status. @entity2 cell lines SW48 (wild-type @entity6 ) and LS174T (mutant @entity6 ) were treated with @entity8 , CTX and a combination of both drugs. @entity4 was measured using the @entity3 assay. Changes in the levels of intracellular signaling proteins were evaluated using western blot analysis. Finally, we evaluated the efficacy of the combination treatment in an in vivo xenograft model. We observed that @entity8 apparently inhibited growth in both cell lines, whereas CTX showed little effect. @entity8 also increased the levels of unprenylated RAS. Combined @entity8 and CTX treatment was synergistic in both cell lines and was associated with inhibition of the RAS-MAPK and AKT-mTOR signaling pathways. Furthermore, the combination treatment was more effective in suppressing the growth of xenografts derived from both SW48 and LS174T cells; this effect was associated with increased apoptosis. These results demonstrate that @entity8 inhibits the growth of @entity5 cells regardless of @entity6 status, and combination therapy using @entity8 and CTX enhances this growth suppression. These findings suggest a novel strategy for the treatment of @entity2 independent of @entity6 mutational status.

title: Combination therapy with XXXX and cetuximab effectively suppresses growth of @entity2 cells regardless of @entity6 status.

answer: @entity7


abstract: UNASSIGNED: Targeted molecular therapy is an effective anticancer strategy. Anti-EGFR monoclonal antibodies such as cetuximab (CTX) have been approved for the treatment of various @entity1 , including @entity2 ( @entity2 ) with wild-type @entity6 . However, their efficacy in @entity0 with @entity6 mutations has not been established. Therefore, we investigated whether CTX treatment was effective as a single agent or in combination with @entity7 ( @entity8 ) in @entity0 @entity2 cell lines with different @entity6 status. @entity2 cell lines SW48 (wild-type @entity6 ) and LS174T (mutant @entity6 ) were treated with @entity8 , CTX and a combination of both drugs. @entity4 was measured using the @entity3 assay. Changes in the levels of intracellular signaling proteins were evaluated using western blot analysis. Finally, we evaluated the efficacy of the combination treatment in an in vivo xenograft model. We observed that @entity8 apparently inhibited growth in both cell lines, whereas CTX showed little effect. @entity8 also increased the levels of unprenylated RAS. Combined @entity8 and CTX treatment was synergistic in both cell lines and was associated with inhibition of the RAS-MAPK and AKT-mTOR signaling pathways. Furthermore, the combination treatment was more effective in suppressing the growth of xenografts derived from both SW48 and LS174T cells; this effect was associated with increased apoptosis. These results demonstrate that @entity8 inhibits the growth of @entity5 cells regardless of @entity6 status, and combination therapy using @entity8 and CTX enhances this growth suppression. These findings suggest a novel strategy for the treatment of @entity2 independent of @entity6 mutational status.

title: Combination therapy with @entity7 and cetuximab effectively suppresses growth of XXXX cells regardless of @entity6 status.

answer: @entity2


abstract: UNASSIGNED: Targeted molecular therapy is an effective anticancer strategy. Anti-EGFR monoclonal antibodies such as cetuximab (CTX) have been approved for the treatment of various @entity1 , including @entity2 ( @entity2 ) with wild-type @entity6 . However, their efficacy in @entity0 with @entity6 mutations has not been established. Therefore, we investigated whether CTX treatment was effective as a single agent or in combination with @entity7 ( @entity8 ) in @entity0 @entity2 cell lines with different @entity6 status. @entity2 cell lines SW48 (wild-type @entity6 ) and LS174T (mutant @entity6 ) were treated with @entity8 , CTX and a combination of both drugs. @entity4 was measured using the @entity3 assay. Changes in the levels of intracellular signaling proteins were evaluated using western blot analysis. Finally, we evaluated the efficacy of the combination treatment in an in vivo xenograft model. We observed that @entity8 apparently inhibited growth in both cell lines, whereas CTX showed little effect. @entity8 also increased the levels of unprenylated RAS. Combined @entity8 and CTX treatment was synergistic in both cell lines and was associated with inhibition of the RAS-MAPK and AKT-mTOR signaling pathways. Furthermore, the combination treatment was more effective in suppressing the growth of xenografts derived from both SW48 and LS174T cells; this effect was associated with increased apoptosis. These results demonstrate that @entity8 inhibits the growth of @entity5 cells regardless of @entity6 status, and combination therapy using @entity8 and CTX enhances this growth suppression. These findings suggest a novel strategy for the treatment of @entity2 independent of @entity6 mutational status.

title: Combination therapy with @entity7 and cetuximab effectively suppresses growth of @entity2 cells regardless of XXXX status.

answer: @entity6


abstract: Purpose: The integrity of selective attention in @entity0 with @entity2 (PWA) is currently unknown. Selective attention is essential for everyday communication, and inhibition is an important part of selective attention. This study explored components of inhibition - intentional and reactive inhibition - during spoken word production in PWA and neurologically @entity1 ( @entity1 ). Intentional inhibition is the ability to suppress a response to interference, and reactive inhibition is the delayed reactivation of a previously suppressed item. Methods: Nineteen PWA and twenty age- and education-matched @entity1 participated in a Stroop spoken word production task. This task allowed the examination of intentional and reactive inhibition by evoking and comparing interference, facilitation, and negative priming effects in different contexts. Results: While both groups demonstrated intentional inhibition, PWA demonstrated significantly more interference effects. PWA demonstrated no significant facilitation effects. @entity1 demonstrated significant reverse facilitation effects. Neither group showed significant evidence of reactive inhibition, though both groups showed similar individual variability. Conclusions: These results underscore the challenge interference presents for PWA during spoken word production, indicating diminished intentional inhibition. While reactive inhibition was not different between PWA and HCs, PWA evidence difficulty integrating and adapting to contextual information during language tasks.

title: Intentional and reactive inhibition during spoken-word Stroop task performance in @entity0 with XXXX .

answer: @entity2


abstract: Purpose: The integrity of selective attention in @entity0 with @entity2 (PWA) is currently unknown. Selective attention is essential for everyday communication, and inhibition is an important part of selective attention. This study explored components of inhibition - intentional and reactive inhibition - during spoken word production in PWA and neurologically @entity1 ( @entity1 ). Intentional inhibition is the ability to suppress a response to interference, and reactive inhibition is the delayed reactivation of a previously suppressed item. Methods: Nineteen PWA and twenty age- and education-matched @entity1 participated in a Stroop spoken word production task. This task allowed the examination of intentional and reactive inhibition by evoking and comparing interference, facilitation, and negative priming effects in different contexts. Results: While both groups demonstrated intentional inhibition, PWA demonstrated significantly more interference effects. PWA demonstrated no significant facilitation effects. @entity1 demonstrated significant reverse facilitation effects. Neither group showed significant evidence of reactive inhibition, though both groups showed similar individual variability. Conclusions: These results underscore the challenge interference presents for PWA during spoken word production, indicating diminished intentional inhibition. While reactive inhibition was not different between PWA and HCs, PWA evidence difficulty integrating and adapting to contextual information during language tasks.

title: Intentional and reactive inhibition during spoken-word Stroop task performance in XXXX with @entity2 .

answer: @entity0


abstract: OBJECTIVES: To measure and calculate the energy expended by @entity0 with @entity1 during near @entity2 (lying, supported and unsupported sitting, standing, wheelchair propulsion, walking), under controlled laboratory conditions, and to compare these values with the energy expenditure of 1.5 metabolic equivalent task (MET) within the definition of sedentary behavior. DESIGN: Cross-sectional cohort study. SETTING: Rehabilitation institutions. @entity0 : @entity0 with @entity1 (N=27; mean age, 61.0  11.7y), categorized at Functional Ambulation Categories (FAC) 0 to  5. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Energy expenditure (measured using indirect calorimetry) expressed in METs. The recorded values were calculated for every @entity0 and averaged for each activity: lying, supported and unsupported sitting, standing, wheelchair propulsion, and walking. Calculations were done for the total group and categorized by the FAC. RESULTS: For the total group the mean METs    SDs were 1.04  .11 for sitting supported, 1.09  .15 for sitting unsupported, 1.31  .25 for standing, 1.91  .42 for wheelchair propulsion, and 2.52  .55 for walking. @entity0 with @entity1 in all FAC had METs values >1.5 when propelling a  wheelchair or walking. CONCLUSIONS: Energy expenditure during typical @entity2 (ie, sitting) is narrowly bounded at approximately 1.0 MET. Energy expenditure during sitting and standing was  <=1.5 MET for all FAC, with the exception of FAC 0 (1.6 MET during standing). Independent wheelchair propulsion and walking can be categorized as light activities (>= 1.5 MET).

title: Characterizing Energy Expenditure During Sedentary Behavior After XXXX .

answer: @entity1


abstract: BACKGROUND: @entity1 is a major concern during medical abortion but no evidence-based recommendations for optimal analgesia during medical termination of pregnancy are available. We compared two methods of epidural analgesia during second trimester termination of pregnancy, with the primary aim of assessing the incidence of @entity3 . METHODS: @entity0 were randomly assigned to receive continuous epidural infusion (CEI Group; n=52) or programmed intermittent epidural bolus (PIEB Group; n=52). Assessment of @entity3 was performed every hour. @entity0 with a modified Bromage score <6 were considered to have @entity3 . RESULTS: Motor block occurred more frequently in the CEI Group compared with the PIEB Group (46.2% vs. 5.8%, P<0.001). @entity1 scores were low and comparable between groups. @entity0 in the CEI Group experienced @entity2 more frequently than those in the PIEB Group (34.6% vs. 13.5%, P=0.022). The degree of satisfaction was higher in the PIEB Group compared with the CEI Group. CONCLUSIONS: During second trimester termination of pregnancy in our @entity0 groups, a programmed intermittent epidural bolus technique was associated with less @entity3 and greater @entity0 satisfaction than continuous epidural infusion. Both techniques had similar analgesic efficacy.

title: Programmed intermittent epidural bolus versus continuous epidural infusion for XXXX relief during termination of pregnancy: a prospective, double-blind, randomized trial.

answer: @entity1


abstract: BACKGROUND: The superior hypogastric plexus (SHGP) carries afferents from the viscera of the lower abdomen and pelvis. @entity3 of this plexus is used for reducing @entity2 resulting from @entity1 in these organs. The ganglion impar (GI) innervats the perineum, distal rectum, anus, distal urethra, vulva, and distal third of the vagina. Different approaches to the ganglion impar neurolysis have been described in the literature. OBJECTIVES: To assess the feasibility, safety, and efficacy of combining the block of the SHGP through the postero-median transdiscal approach with the @entity3 by the trans-sacro-coccygeal approach for relief of pelvic and/or perineal @entity2 caused by pelvic and/or perineal @entity1 or any @entity1 related causes. METHODS: Fifteen @entity0 who had @entity1 -related pelvic @entity2 , or both received a combined SHGP @entity3 through the postero-median transdiscal approach using a 20-gauge Chiba needle and injection of 10 mL of 10% @entity5 in saline plus a GI @entity3 by the trans-sacro-coccygeal approach using a 22-gauge 5 cm needle and injection of 4 - 6 mL of 8% @entity5 in saline. @entity2 intensity (measured using a visual analogue scale) and oral @entity4 consumption pre- and post-procedure were measured. RESULTS: All @entity0 presented with @entity1 . @entity2 scores were reduced from a mean (   SD) of 7.87    1.19 pre-procedurally to 2.40    2.10 one week post-procedurally (P < 0.05). In addition, the mean consumption of @entity4 (delivered via 30 mg sustained-release @entity4 tablets) was reduced from 98.00    34.89 mg to 32.00    28.48 mg after one week (P < 0.05). No complications or serious side effects were encountered during or after the block. LIMITATIONS: This study is limited by its small sample size and non-randomized study. CONCLUSION: A combined neurolytic SHGP block with @entity3 is an effective and safe technique for reducing @entity2 in @entity1 @entity0 presented with pelvic and/or perineal @entity2 . Also, a combined SHGP block through a posteromedian transdiscal approach with a @entity3 through a trans-sacrococcygeal approach may be considered more effective and easier to perform than the recently invented bilateral inferior hypogastric plexus neurolysis through a transsacral approach.

title: Superior Hypogastric Plexus Combined with Ganglion Impar Neurolytic Blocks for Pelvic and/or Perineal XXXX Relief.

answer: @entity1


abstract: BACKGROUND: A Fontan Y-shaped graft using a commercially available aortoiliac graft has been used to connect the inferior vena @entity2 (IVC) to the pulmonary arteries. This modification of the Fontan procedure seeks to improve hepatic flow distribution (HFD) to the lungs. However, @entity0 -specific anatomical restrictions might limit the space available for graft placement. Altering the superior vena @entity2 ( @entity1 ) positioning is hypothesized to provide more space for an optimal connection, avoiding caval flow collision. Computational modeling tools were used to retrospectively study the effect of @entity1 placement on Y-graft hemodynamics. METHODS: @entity0 -specific anatomies (N  = 10 @entity0 ) and vessel flows were reconstructed from retrospective cardiac magnetic resonance (CMR) images after Fontan Y-graft completion. Alternative geometries were created using a virtual surgery environment, altering the @entity1 position and the offset in relation to the Y-graft branches. Geometric characterization and computational fluid dynamics simulations were performed. Hemodynamic factors (power loss and HFD) were computed. RESULTS: @entity0 with a higher IVC return showed less sensitivity to @entity1 positioning. @entity0 with low IVC flow showed varied HFD results, depending on @entity1 location. Balanced HFD values (50% to each lung) were obtained when the @entity1 lay completely between the Y-graft branches. The effect on power loss was @entity0 specific. CONCLUSIONS: @entity1 positioning with respect to the Y-graft affects HFD, especially in @entity0 with lower IVC flow. Careful positioning of the @entity1 at the time of a bidirectional Glenn (BDG) procedure based on @entity0 -specific anatomy can optimize the hemodynamics of the eventual Fontan completion.

title: Hemodynamic Impact of Superior Vena XXXX Placement in the Y-Graft Fontan Connection.

answer: @entity2


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a highly contagious vesicular disease that affects domestic and wild cloven-hoofed animals worldwide. Recently, a series of outbreaks of type A FMDV occurred in Southeast Asian countries, China, the Russia Federation, Mongolia, Kazakhstan and South Korea. The @entity3 virus (A/GDMM/ @entity4 /2013) from China's Guangdong province (2013) is representative of those responsible for the latest epidemic, and has low @entity2 identity (93.9%) in VP1 protein with the epidemic strain A/WH/ @entity4 /09 from Wuhan, China in 2009. Both of isolates belong to the Sea-97 genotype of ASIA topotype. Therefore, the application of a new vaccine strain with cross-protective efficacy is of fundamental importance to control the spread of the two described pandemic strains. A chimeric strain rA/P1-FMDV constructed by our lab previously through replacing the P1 gene in the vaccine strain O/ @entity4 /99 with that from the epidemic stain A/WH/ @entity4 /09, has been demonstrated to exhibit good growth characteristics in culture, and the rA/P1-FMDV inactivated vaccine can provide protection against epidemic strain A/WH/ @entity4 /09 in @entity0 . However, it is still unclear whether the vaccine produces efficient protection against the new pandemic strain (A/GDMM/ @entity4 /2013). Here, vaccine matching and @entity1 50% protective dose (PD50) tests were performed to assess the vaccine potency. The vaccine matching test showed cross-reactivity of sera from full dose vaccine vaccinated @entity1 with A/WH/ @entity4 /09 and A/GDMM/ @entity4 /2013 isolates, with average r1 values of 0.94  0.12 and 0.68  0.06 (r1>= 0.3), which indicates that the rA/P1-FMDV vaccine is likely to confer good cross-protection against the two isolates. When challenged with two pandemic isolates A/WH/ @entity4 /09 and A/GDMM/ @entity4 /2013 strain, the vaccine achieved 12.51 PD50 and 10.05 PD50 per dose (2.8 g), respectively. The results indicated that the rA/P1-FMDV inactivated vaccine could protect @entity1 against both A/WH/ @entity4 /09 and A/GDMM/ @entity4 /2013 pandemic isolates.

title: Cross-protective efficacy of engineering serotype A XXXX virus vaccine against the two pandemic strains in @entity1 .

answer: @entity3


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a highly contagious vesicular disease that affects domestic and wild cloven-hoofed animals worldwide. Recently, a series of outbreaks of type A FMDV occurred in Southeast Asian countries, China, the Russia Federation, Mongolia, Kazakhstan and South Korea. The @entity3 virus (A/GDMM/ @entity4 /2013) from China's Guangdong province (2013) is representative of those responsible for the latest epidemic, and has low @entity2 identity (93.9%) in VP1 protein with the epidemic strain A/WH/ @entity4 /09 from Wuhan, China in 2009. Both of isolates belong to the Sea-97 genotype of ASIA topotype. Therefore, the application of a new vaccine strain with cross-protective efficacy is of fundamental importance to control the spread of the two described pandemic strains. A chimeric strain rA/P1-FMDV constructed by our lab previously through replacing the P1 gene in the vaccine strain O/ @entity4 /99 with that from the epidemic stain A/WH/ @entity4 /09, has been demonstrated to exhibit good growth characteristics in culture, and the rA/P1-FMDV inactivated vaccine can provide protection against epidemic strain A/WH/ @entity4 /09 in @entity0 . However, it is still unclear whether the vaccine produces efficient protection against the new pandemic strain (A/GDMM/ @entity4 /2013). Here, vaccine matching and @entity1 50% protective dose (PD50) tests were performed to assess the vaccine potency. The vaccine matching test showed cross-reactivity of sera from full dose vaccine vaccinated @entity1 with A/WH/ @entity4 /09 and A/GDMM/ @entity4 /2013 isolates, with average r1 values of 0.94  0.12 and 0.68  0.06 (r1>= 0.3), which indicates that the rA/P1-FMDV vaccine is likely to confer good cross-protection against the two isolates. When challenged with two pandemic isolates A/WH/ @entity4 /09 and A/GDMM/ @entity4 /2013 strain, the vaccine achieved 12.51 PD50 and 10.05 PD50 per dose (2.8 g), respectively. The results indicated that the rA/P1-FMDV inactivated vaccine could protect @entity1 against both A/WH/ @entity4 /09 and A/GDMM/ @entity4 /2013 pandemic isolates.

title: Cross-protective efficacy of engineering serotype A @entity3 virus vaccine against the two pandemic strains in XXXX .

answer: @entity1


abstract: PURPOSE:: To report the results of @entity1 injection into the orbicularis oculi muscle to treat lagophthalmos in @entity0 with long-standing Bell palsy. METHODS:: In this prospective interventional case series, @entity1 , 5 ml of a 0.750% solution, was injected into the preseptal and pretarsal area of the orbicularis oculi in each of 10 @entity0 with @entity2 . The measures of vertical eyelid apertures during open and closed eyes were made before the procedure and 1, 3, and 6 months after injection. RESULTS:: A total of 10 eyes including 2 @entity0 and 8 @entity0 with an average age of 43 years (26-64 years) were studied. The mean amount of lagophthalmos before injection and after 6 months of follow up were 3.9 mm and 2.3 mm, respectively (p = 0.01)). The mean amount of corneal exposure before injection and after 6 months of follow up was 1.05 mm and 0.25 mm, respectively (p < 0.01). The mean scleral show in open eyes before injection and after 6 months of follow up were 1.20 mm and 0.75 mm, respectively (p = 0.08). The mean scleral show in closed eyes before injection and after 6 months of follow up were 1.95 mm and 1.15 mm, respectively (p = 0.01). All the @entity0 reported significant @entity3 . CONCLUSION:: @entity1 injection in the paretic orbicularis oculi muscle improves eyelid closure and lagophthalmos and @entity3 .

title: XXXX Injection for Management of Lagophthalmos Due to Long-Standing Idiopathic Facial Nerve Palsy.

answer: @entity1


abstract: PURPOSE: To analyze changes in intraocular pressure (IOP) after @entity1 surgery based on data from the Swedish National @entity1 Register (NCR). SETTING: Ophthalmic surgery units in Sweden. DESIGN: Prospective database study. METHODS: Data for 2012 through 2014 were obtained prospectively from the NCR. The outcome register of the NCR has collected data on IOP before and a mean of 37.7 days    29.1 (SD) after @entity1 surgery since  2012. RESULTS: The analyses were based on 20   437 @entity1 extractions reported during 1 month each year to the outcome registry of the NCR. @entity1 surgery was found to reduce IOP by a mean of 1.46 mm Hg, which was statistically significant (P < .001). A larger IOP reduction was seen in cases with a higher preoperative IOP (r = 0.557, P < .001). Older @entity0 and @entity3 had a greater IOP reduction after surgery (P < .001 and P = .001, respectively). @entity0 had a greater IOP reduction than @entity0 (P = .04) When high IOP was given as an indication for surgery, the IOP reduction after @entity1 surgery was 5.50 mm Hg compared with a reduction of 1.40 mm Hg in @entity0 for whom this indication was not given (P < .001). @entity0 with @entity2 or @entity4 ( @entity4 ) had a more pronounced IOP reduction than @entity0 without these diagnoses (P < .001). CONCLUSION: @entity1 surgery had an IOP-lowering effect, in particular in older @entity0 , @entity0 , @entity3 , eyes with high preoperative IOP, and eyes with @entity2 or @entity4 . FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Changes in intraocular pressure after  XXXX surgery: Analysis of the Swedish National @entity1 Register Data.

answer: @entity1


abstract: PURPOSE: To analyze changes in intraocular pressure (IOP) after @entity1 surgery based on data from the Swedish National @entity1 Register (NCR). SETTING: Ophthalmic surgery units in Sweden. DESIGN: Prospective database study. METHODS: Data for 2012 through 2014 were obtained prospectively from the NCR. The outcome register of the NCR has collected data on IOP before and a mean of 37.7 days    29.1 (SD) after @entity1 surgery since  2012. RESULTS: The analyses were based on 20   437 @entity1 extractions reported during 1 month each year to the outcome registry of the NCR. @entity1 surgery was found to reduce IOP by a mean of 1.46 mm Hg, which was statistically significant (P < .001). A larger IOP reduction was seen in cases with a higher preoperative IOP (r = 0.557, P < .001). Older @entity0 and @entity3 had a greater IOP reduction after surgery (P < .001 and P = .001, respectively). @entity0 had a greater IOP reduction than @entity0 (P = .04) When high IOP was given as an indication for surgery, the IOP reduction after @entity1 surgery was 5.50 mm Hg compared with a reduction of 1.40 mm Hg in @entity0 for whom this indication was not given (P < .001). @entity0 with @entity2 or @entity4 ( @entity4 ) had a more pronounced IOP reduction than @entity0 without these diagnoses (P < .001). CONCLUSION: @entity1 surgery had an IOP-lowering effect, in particular in older @entity0 , @entity0 , @entity3 , eyes with high preoperative IOP, and eyes with @entity2 or @entity4 . FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Changes in intraocular pressure after  @entity1 surgery: Analysis of the Swedish National XXXX Register Data.

answer: @entity1


abstract: OBJECTIVES: The aim was to analyse a prospective, consecutive series of awake carotid endarterectomy (CEA) @entity0 undergoing, when possible, pre- and postoperative diffusion-weighted magnetic resonance imaging brain scans (DWI). METHODS: All CEA @entity0 from June 23, 2006, to January 13, 2012, were prospectively entered in the study. CEA was performed under regional cervical block. Only @entity0 demonstrating shunt @entity3 were shunted. Before August 7, 2008, all longitudinal endarterectomy had been performed with a vein patch. From that date all CEA were eversions without a patch, except shunted @entity0 who were vein patched. DWI was performed 2 days before and 5 days after (3 Tesla). Scans were reported by MRI-trained radiologists. Logistic regression analysis (LRA) identified predictive variables for MRI changes using backward stepwise elimination of variables with p  >  .05. RESULTS: There was a total of 295 consecutive CEA. There were no deaths but four clinical @entity1 (1.4 %); 89 excluded from DWI leaving 206; of these 27 (13%) developed new @entity2 including four of 57 (7%) in the asymptomatic group and 23 of 149 (15%) symptomatic @entity0 . Nineteen of the 206 (9.2%) were shunted. LRA showed that shunt @entity3 was highly associated with new @entity2 : odds ratio (OR) 6.43; 95% confidence interval (CI) 2.3-17.9; p  <  .001. Both the vein patched, non-shunted group (OR .25; CI 0.09-0.72; p  =  .010) and the eversion (all non-shunted and all non-patched) group (OR 0.05; CI 0.01-0.22; p  <  .001) were associated with a low risk of new lesions, with the eversion group a lower risk than the patched group. CONCLUSIONS: One in every eight CEA @entity0 developed new @entity2 (rate doubled in symptomatic @entity0 ). Shunt @entity3 in conscious CEA @entity0 is highly associated with the development of new @entity2 compared with non-shunted @entity0 . For non-shunted @entity0 the new lesion risk is low, and in those @entity0 the risk in the eversion group is lower than in the patched group.

title: Operative Factors Associated with the Development of New XXXX During Awake Carotid Endarterectomy.

answer: @entity2


abstract: OBJECTIVE: The outcomes of open surgical or endovascular intervention for limb-threatening @entity1 (LTI) involving the infrapopliteal vessels are dependent on complex anatomic, demographic, and disease factors. To assist in decision-making, we used the Vascular Quality Initiative (VQI) to derive a model using only preoperatively available factors to predict important outcomes for open or endovascular revascularization. METHODS: National VQI data for the infrainguinal bypass and peripheral vascular intervention (PVI) modules were reviewed in a blinded fashion for @entity0 who underwent intervention for LTI of the infrapopliteal vessels. Primary outcomes consisted of major adverse limb event (MALE) and amputation-free survival (AFS). Generalized linear modeling was used for the multivariate analyses, with entry of variables dependent on results of univariate analysis. RESULTS: From January 2003 through August 2014 a total of 19,053 infrainguinal open bypass and 48,739 PVI procedures were identified, among which 5264 and 5252, respectively, represented infrapopliteal (tibial-peroneal-pedal) revascularization for LTI. From these, 3036 infrapopliteal open bypass @entity0 and 1319 infrapopliteal PVI @entity0 had sufficient follow-up data for study inclusion. For open surgery, the reduced generalized linear model revealed that American Society of Anesthesiologists class 4 or 5, previous major amputation, living at home, and female sex had the greatest adverse effect on MALE, and dialysis dependence, low body mass index, and lack of great saphenous vein as a conduit had the greatest negative effect on AFS. For PVI, lesion length from 10 to 15  cm, treatment of three or more arteries, and classification other than A on the Trans-Atlantic Inter-Society Consensus demonstrated the largest adverse effects on MALE, and dialysis dependence, low body mass index, and @entity2 most negatively affected AFS. CONCLUSIONS: This study on a cross-section of @entity0 selected for intervention in academic and community hospitals offers a "real world" glimpse of factors predictive of outcome. The VQI can be used to derive models that predict the outcomes of open surgical bypass or PVI for LTI involving the infrapopliteal vessels.

title: Predicting outcomes for infrapopliteal limb-threatening XXXX using the Society for Vascular Surgery Vascular Quality Initiative.

answer: @entity1


abstract: INTRODUCTION: Threats to quality and @entity0 safety may exist when necessary nursing care is omitted. Empirical research is needed to determine how missed nursing care is associated with @entity0 outcomes. AIM: The aim of this study was to examine the relationship between missed nursing care and hospital readmissions. METHODS: Cross-sectional examination, using three linked data sources-(1) nurse survey, (2) @entity0 discharge data from three states (California, New Jersey and Pennsylvania) and (3) administrative hospital data- from 2005 to 2006. We explored the incidence of 30-day readmission for 160   930 @entity0 with @entity1 in 419 acute care hospitals in the USA. Logistic regression was used to assess the effect of missed care on the odds of readmission, adjusting for @entity0 and hospital characteristics. RESULTS: The most frequently missed nursing care activities across all hospitals in our sample included talking to and comforting @entity0 (42.0%), developing and updating care plans (35.8%) and educating @entity0 and families (31.5%). For 4 of the 10 studied care activities, each 10 percentage-point increase in the number of nurses reporting having missed the activity was associated with an increase in the odds of readmission by 2-8% after adjusting for @entity0 and hospital characteristics. However, missed nursing care was no longer a significant predictor of readmission once adjusting for the nurse work environment, except in the case of the delivery of treatments and procedures (OR 1.08, 95% CI 1.02 to 1.14). CONCLUSIONS: Missed care is an independent predictor of @entity1 readmissions. However, once adjusting for the quality of the nurse work environment, this relationship is attenuated. Improvements in nurses' working conditions may be one strategy to reduce care omissions and improve @entity0 outcomes.

title: The quality of hospital work environments and missed nursing care is linked to XXXX readmissions: a cross-sectional study of US hospitals.

answer: @entity1


abstract: OBJECTIVES: @entity3 Juan (LJ, ) is a syndrome described in Chinese medicine (CM) that manifests with @entity1 , fever, spontaneous sweating, indigestion, work-induced @entity0 , weakness of the limbs, and @entity2 . The present study was conducted to examine the reliability and validity of a @entity3 Juan Questionnaire (LJQ). METHODS: A total of 151 outpatients and 73 normal subjects were asked to complete the LJQ. Seventy-three normal subjects were additionally asked to complete the @entity1 ( @entity1 ). Twelve clinicians determined whether the 151 outpatients exhibited LJ or not. The internal consistency and construct validity for the LJQ were estimated using data from the outpatient subjects. The @entity1 data were used to examine the concurrent validity of the LJQ. Total LJQ scores and the clinicians' diagnoses of the outpatients were used to perform receiver operating characteristics (ROC) curve analyses and to define an optimum cut-off score for the LJQ. RESULTS: The 19-item LJQ had satisfactory internal consistency (a=0.828) and concurrent validity, with significant correlations between the LJQ and the @entity1 subscales. In the test of construct validity using principal component analysis, a total of six factors were extracted, and the overall variance explained by all factors was 59.5%. In ROC curve analyses, the sensitivity, specificity, and area under the curve were 76.0%, 59.2%, and 0.709, respectively. The optimum cut-off score was defined as six points. CONCLUSIONS: Our results suggest that the LJQ is a reliable and valid instrument for evaluating LJ.

title: Development and validation of a XXXX Juan () Questionnaire.

answer: @entity3


abstract: UNASSIGNED: The present study aimed to observe the level of @entity1 and the number of lesions in the airways and parenchyma of @entity0 lungs subsequent to smoking cessation following 4  weeks exposure to cigarette smoke. Enlargement of the regional airspaces, deposition of peribronchial collagen fibers and macrophage infiltration were assessed. In addition, the expression levels of @entity5 and transforming growth factor (TGF)  -b1 were detected in the airways and @entity2 of C57BL/6  J @entity0 . @entity0 , which were exposed to filtered air for 4  weeks or cigarette smoke for 8  weeks were used as control groups. A 4  week duration of smoke exposure induced the expansion of alveolar spaces ~100    m from the terminal bronchioles, but without increased deposition of collagen around the small airways, which was not reversed following smoking cessation. Pulmonary infiltration of macrophages and the protein expression levels of @entity5 and @entity3 increased in the airways following 4  weeks smoke exposure, however, there was no further increase at 8  weeks, and the expression levels of @entity3 in the @entity2 decreased. At 4  weeks post  -smoking cessation, the expression levels of @entity3 in the airways and @entity2 returned to normal; whereas, 1  week after smoking cessation, the expression levels of @entity5 were higher compared with the normal control group. Subacute exposure to cigarette smoke induced an inflammatory response and regional damage to the @entity2 , prior to deposition of collagen around the airways. Following smoking cessation, the pulmonary inflammatory reaction was partially reversed, however, macrophage infiltration and the expression levels of @entity5 remained significantly higher compared with the control @entity0 . These results suggested that regulation of the expression of @entity5 and @entity3 , particularly in the distribution in the airways and @entity2 , may be a strategy for the early treatment of @entity4 .

title: XXXX and pathological damage to the lungs of @entity0 are only partially reversed following smoking cessation on subacute exposure to cigarette smoke.

answer: @entity1


abstract: UNASSIGNED: The present study aimed to observe the level of @entity1 and the number of lesions in the airways and parenchyma of @entity0 lungs subsequent to smoking cessation following 4  weeks exposure to cigarette smoke. Enlargement of the regional airspaces, deposition of peribronchial collagen fibers and macrophage infiltration were assessed. In addition, the expression levels of @entity5 and transforming growth factor (TGF)  -b1 were detected in the airways and @entity2 of C57BL/6  J @entity0 . @entity0 , which were exposed to filtered air for 4  weeks or cigarette smoke for 8  weeks were used as control groups. A 4  week duration of smoke exposure induced the expansion of alveolar spaces ~100    m from the terminal bronchioles, but without increased deposition of collagen around the small airways, which was not reversed following smoking cessation. Pulmonary infiltration of macrophages and the protein expression levels of @entity5 and @entity3 increased in the airways following 4  weeks smoke exposure, however, there was no further increase at 8  weeks, and the expression levels of @entity3 in the @entity2 decreased. At 4  weeks post  -smoking cessation, the expression levels of @entity3 in the airways and @entity2 returned to normal; whereas, 1  week after smoking cessation, the expression levels of @entity5 were higher compared with the normal control group. Subacute exposure to cigarette smoke induced an inflammatory response and regional damage to the @entity2 , prior to deposition of collagen around the airways. Following smoking cessation, the pulmonary inflammatory reaction was partially reversed, however, macrophage infiltration and the expression levels of @entity5 remained significantly higher compared with the control @entity0 . These results suggested that regulation of the expression of @entity5 and @entity3 , particularly in the distribution in the airways and @entity2 , may be a strategy for the early treatment of @entity4 .

title: @entity1 and pathological damage to the lungs of XXXX are only partially reversed following smoking cessation on subacute exposure to cigarette smoke.

answer: @entity0


abstract: OBJECTIVE: It was tested as to why low-dose @entity4 ( @entity5 ) effective against @entity2 poses considerable health risk at higher doses. METHODS: The tumorigenic potential of My1/De blast cells was followed by cytology and by the kinetics of @entity3 uptake. The @entity1 of @entity5 on chromatin condensation was compared to predictive normal intermediates of chromosome condensation in control cells. RESULTS: @entity5 below 0.1    g/ml did not cause visible changes in interphase chromatin structure. At its lowest toxic concentration (0.1    g/ml) chromatin margination was confined to the outer edge of the nucleus. Between 0.1 and 5    g/ml concentrations apoptotic chromatin shrinkage correlated with the dose of @entity5 . Apoptosis was exerted in early S phase excluding the mitotic effect. At higher @entity5 concentrations (>10    g/ml) necrotic disruption and expansion took place. The lowest necrotic concentration (10    g/ml) was close to highest apoptotic @entity5 concentration (5    g/ml). CONCLUSIONS: The switch from apoptosis to @entity0 taking place within a narrow concentration range supports the notion of a narrow therapeutic spectrum. Chromatin changes are early markers of genotoxicity at much lower concentrations than citogenetic changes in properly chosen sensitive cells.

title: XXXX induced apoptotic and necrotic chromatin changes in rat myeloid leukemia cells.

answer: @entity4


abstract: OBJECTIVE: Guidelines for pharmacologic @entity3 ( @entity3 ) prophylaxis from the American Congress of Obstetricians (ACOG), the Royal College of Obstetricians and Gynaecologists (RCOG), and the American College of Chest Physicians (Chest) vary significantly. The objective of this study was to determine the practical implications of these recommendations in terms of prophylaxis rates for a tertiary obstetric population. STUDY DESIGN: Cross-sectional. SETTING: Tertiary referral hospital. POPULATION: @entity0 post-operative day 1 after caesarean delivery. METHODS: This cross-sectional study evaluated rates of pharmacologic prophylaxis for @entity0 based on RCOG, ACOG, and Chest recommendations. Medical, obstetric, and demographic risk factors for @entity2 were reviewed for individual @entity0 . Rates of prophylaxis based on each of the guidelines with 95% confidence intervals were calculated. OUTCOME MEASURE: Recommended pharmacologic prophylaxis. RESULTS: About 293 @entity0 were included in the analysis. Under RCOG guidelines, 85.0% of @entity0 would receive post-caesarean pharmacologic prophylaxis [95% confidence interval (CI) 80.5-88.6%] compared with 1.0% of @entity0 under ACOG guidelines (95% CI 0.3-3.0%) and 34.8% of @entity0 under Chest guidelines (95% CI 29.6-40.4%). Caesarean during labour, @entity1 , advanced maternal age, @entity4 , and @entity5 were among the most commonrisk factors. CONCLUSION: Recommended prophylaxis differed significantly. Under ACOG recommendations a small minority of @entity0 would receive prophylaxis, whereas under RCOG recommendations a large majority of @entity0 would receive low-molecular-weight heparin. Given the large differences in prophylaxis rates for post-caesarean thromboprophylaxis based on different guidelines, further research is urgently needed to compare the risks and benefits of recommendations. TWEETABLE ABSTRACT: Recommendations from major society guidelines for post-caesarean thromboprophylaxis differ greatly.

title: A comparison of recommendations for pharmacologic XXXX prophylaxis after caesarean delivery from three major guidelines.

answer: @entity2