abstract: INTRODUCTION: @entity4 is now recognised as a leading cause of @entity2 in Malaysia. As @entity0 come into increasing contact with the reservoir host ( @entity3 ) as a consequence of deforestation, assessing the potential for a shift from zoonotic to sustained @entity4 transmission between @entity0 is critical. METHODS: A multi-host, multi-site transmission model was developed, taking into account the three areas (forest, farm, and village) where transmission is thought to occur. Latin hypercube sampling of model parameters was used to identify parameter sets consistent with possible prevalence in macaques and @entity0 inferred from observed data. We then explore the consequences of increasing @entity0 -macaque contact in the farm, the likely impact of rapid treatment, and the use of long-lasting insecticide-treated nets (LLINs) in preventing wider spread of this @entity1 . RESULTS: Identified model parameters were consistent with transmission being sustained by the macaques with spill over infections into the @entity0 population and with high overall basic reproduction numbers (up to 2267). The extent to which macaques forage in the farms had a non-linear relationship with @entity0 @entity1 prevalence, the highest prevalence occurring when macaques forage in the farms but return frequently to the forest where they experience higher contact with vectors and hence sustain transmission. Only one of 1,046 parameter sets was consistent with sustained @entity0 -to- @entity0 transmission in the absence of macaques, although with a low @entity0 reproduction number (R(0H) = 1.04). Simulations showed LLINs and rapid treatment provide personal protection to @entity0 with maximal estimated reductions in @entity0 prevalence of 42% and 95%, respectively. CONCLUSION: This model simulates conditions where @entity4 transmission may occur and the potential impact of control measures. Predictions suggest that conventional control measures are sufficient at reducing the risk of @entity1 in @entity0 , but they must be actively implemented if @entity4 is to be controlled.

title: Transmission and control of XXXX : a mathematical modelling study.

answer: @entity4


abstract: Increasing survival rates in @entity1 have yielded a growing population of parents of @entity1 survivors (CCSs). This systematic review compiles the literature on positive and negative long-term @entity2 for parents of CCSs, reported at least five years after the @entity0 's diagnosis and/or two years after the end of the @entity0 's treatment. Systematic searches were made in the databases CINAHL, EMBASE, PsycINFO, and PubMed. Fifteen studies, published between 1988 and 2010, from 12 projects were included. Thirteen studies used quantitative methodology, one quantitative and qualitative methodology, and one qualitative methodology. A total of 1045 parents participated in the reviewed studies. Mean scores were within normal ranges for general @entity2 , coping, and family functioning. However, a substantial subgroup reported a clinical level of general @entity2 , and 21-44% reported a severe level of posttraumatic stress symptoms. Worry, disease-related thoughts and feelings, marital strains, as well as posttraumatic growth was reported. Several factors were associated with the long-term late effects, such as parents' maladaptive coping during earlier stages of the childs disease trajectory and @entity0 's current poor adjustment. Quality assessments of reviewed studies and clinical implications of findings are discussed and recommendations for future research are presented.

title: Long-term positive and negative XXXX for parents of @entity1 survivors: a systematic review.

answer: @entity2


abstract: Increasing survival rates in @entity1 have yielded a growing population of parents of @entity1 survivors (CCSs). This systematic review compiles the literature on positive and negative long-term @entity2 for parents of CCSs, reported at least five years after the @entity0 's diagnosis and/or two years after the end of the @entity0 's treatment. Systematic searches were made in the databases CINAHL, EMBASE, PsycINFO, and PubMed. Fifteen studies, published between 1988 and 2010, from 12 projects were included. Thirteen studies used quantitative methodology, one quantitative and qualitative methodology, and one qualitative methodology. A total of 1045 parents participated in the reviewed studies. Mean scores were within normal ranges for general @entity2 , coping, and family functioning. However, a substantial subgroup reported a clinical level of general @entity2 , and 21-44% reported a severe level of posttraumatic stress symptoms. Worry, disease-related thoughts and feelings, marital strains, as well as posttraumatic growth was reported. Several factors were associated with the long-term late effects, such as parents' maladaptive coping during earlier stages of the childs disease trajectory and @entity0 's current poor adjustment. Quality assessments of reviewed studies and clinical implications of findings are discussed and recommendations for future research are presented.

title: Long-term positive and negative @entity2 for parents of XXXX survivors: a systematic review.

answer: @entity1


abstract: Serological diagnosis of @entity3 ( @entity3 ) is a key element for efficient @entity0 treatment management. A rapid @entity1 ( @entity1 ) using the recombinant Em18 antigen (rEm18) was recently developed. The aim of our study was to assess this test on a panel of sera from French @entity0 with @entity3 and control @entity0 . In a blind test, a total of 112 serum samples were tested including samples of @entity3 (n  =  30), @entity5 [ @entity5 ] (n  =  15), and @entity5 [ @entity5 ] (n  =  1). For the comparison, 66 sera from @entity0 with hepatocarcinoma, @entity4 , @entity7 , @entity6 , or @entity2 were used. The diagnostic test sets we used were the rEm18- @entity1 and two validated ELISAs with rEm18 and Em2-Em18 antigens, respectively. For the @entity1 , 27/30 sera from @entity3 @entity0 , 4/15 sera from @entity5 @entity0 and the @entity5 patient serum were positive. One serum from the control panel ( @entity7 ) was positive for the @entity1 . The rEm18- @entity1 sensitivity (90.0%) and specificity (92.7%) for detection of Em18-specific antibodies confirmed it as a relevant tool for @entity3 diagnosis. The rEm18-ELISA had a sensitivity of 86.7% and specificity of 91.5%, and the Em2-Em18-ELISA had a sensitivity of 96.7% and specificity of 87.8%. However, when @entity3 @entity0 sera are recorded as weak in intensity with the @entity1 , we recommend a double reading and use of a reference sample if the @entity1 is used for @entity0 follow-up.

title: Comparison of the serological tests @entity1 and ELISA for the diagnosis of XXXX in France   .

answer: @entity3


abstract: Serological diagnosis of @entity3 ( @entity3 ) is a key element for efficient @entity0 treatment management. A rapid @entity1 ( @entity1 ) using the recombinant Em18 antigen (rEm18) was recently developed. The aim of our study was to assess this test on a panel of sera from French @entity0 with @entity3 and control @entity0 . In a blind test, a total of 112 serum samples were tested including samples of @entity3 (n  =  30), @entity5 [ @entity5 ] (n  =  15), and @entity5 [ @entity5 ] (n  =  1). For the comparison, 66 sera from @entity0 with hepatocarcinoma, @entity4 , @entity7 , @entity6 , or @entity2 were used. The diagnostic test sets we used were the rEm18- @entity1 and two validated ELISAs with rEm18 and Em2-Em18 antigens, respectively. For the @entity1 , 27/30 sera from @entity3 @entity0 , 4/15 sera from @entity5 @entity0 and the @entity5 patient serum were positive. One serum from the control panel ( @entity7 ) was positive for the @entity1 . The rEm18- @entity1 sensitivity (90.0%) and specificity (92.7%) for detection of Em18-specific antibodies confirmed it as a relevant tool for @entity3 diagnosis. The rEm18-ELISA had a sensitivity of 86.7% and specificity of 91.5%, and the Em2-Em18-ELISA had a sensitivity of 96.7% and specificity of 87.8%. However, when @entity3 @entity0 sera are recorded as weak in intensity with the @entity1 , we recommend a double reading and use of a reference sample if the @entity1 is used for @entity0 follow-up.

title: Comparison of the serological tests XXXX and ELISA for the diagnosis of @entity3 in France   .

answer: @entity1


abstract: Abstract The purpose of this study was to evaluate the presence of extracapsular invasion (ECI) in positive sentinel lymph nodes (SLNs) as a predictor of disease recurrence in @entity0 . @entity2 biopsy was performed on 318 breasts of 316 @entity0 @entity1 , of which 50 (15.7%) had positive SLNs. Six (12.0%) of these 50 cases had disease recurrence. The clinicopathologic features of these cases were reviewed. The ECI at SLNs was not significantly associated with disease recurrence. The recurrence-free interval by Kaplan-Meier curves did not differ significantly among @entity1 with and without ECI at SLNs. On the other hand, metastasis at non-SLNs was observed in 12 cases (24.0%) among the 50 cases with positive SLNs, and in the non- @entity2 metastasis group there were 7 @entity1 with ECI at non-SLNs. Three of 7 cases with ECI at non-SLNs had disease recurrence and none of those 5 without ECI at non-SLNs had disease recurrence. Our current study suggests that the presence of ECI at metastatic SLNs is not associated with recurrent disease in @entity0 . Our results also imply that @entity1 with ECI at positive non-SLNs have a high risk of disease recurrence.

title: Extracapsular invasion of sentinel lymph nodes is not associated with disease recurrence in XXXX .

answer: @entity0


abstract: Previous studies have reported a meal-induced rise in hepatic glycogen stores from baseline levels following a fast and it is generally assumed that glycogen levels rise steadily following meals throughout the day. However, measurements are normally taken in conditions that are not typical of the Western breakfast, which is relatively @entity1 rich with a lower calorific content than most experimental test meals. As such, little is known about the normal metabolic response to a realistic, low calorie morning meal. Therefore, the aim of this pilot study was to evaluate the effects of a low dose oral @entity0 intake on hepatic glycogen levels following an overnight fast in healthy subjects. Glycogen levels were monitored in vivo using @entity2 Magnetic Resonance Spectroscopy at baseline and hourly for 4 hours following either a 50 g @entity0 drink (773 kJ) or a control drink (0 kJ) given over two different visits. During the control visit hepatic glycogen levels decreased throughout the experiment with statistically significant decreases from baseline at 190 minutes (P < 0.05) and 250 minutes (P < 0.05). By contrast, the low dose @entity0 intake maintained glycogen concentrations with no significant decrease from baseline over 4 hours. A comparison between visits revealed that mean glycogen concentrations were significantly greater during the @entity0 visit (control visit, AUC = 218    39 mol L(-1) min(-1); @entity0 visit, AUC = 305    49 mol L(-1) min(-1); P < 0.05). Liver volume decreased significantly from baseline at 180 minutes (P < 0.05) post consumption in both groups, with no significant difference found between visits. Gastric content volumes were significantly higher for the @entity0 visit immediately following consumption (P < 0.001) and at 60 minutes (P = 0.007) indicating slower gastric emptying for the @entity0 compared with the control. In conclusion, following an overnight fast, a low dose oral @entity0 challenge prevents a reduction in hepatic glycogen content but does not increase it above fasted levels.

title: A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo XXXX magnetic resonance study.

answer: @entity2


abstract: INTRODUCTION: The prevalence of congenital @entity4 is 4 in 10 000 live birth. @entity4 is typically located in the aortic isthmus, but it may occur at atypical sites. Treatment options include both surgical and endovascular interventions. In @entity0 undergoing surgical or endovascular intervention late complications such as recoarctation or aortic @entity2 may develop. AIM: The aim of the authors was to analyse their own experience in late complication and treatment options of @entity4 operated in childhood. METHOD: Retrospective analysis of data of 32 @entity0 treated between 1980 and 2014 for late complications 8-42 years after surgical treatment of @entity4 . RESULTS: In 28 @entity0 @entity2 formation after isthmic patch plasty was found. Two @entity0 had aortobronchial fistula, 2 @entity0 showed @entity1 disruption and 2 @entity0 had graft stenosis. During operation hybrid solution was performed in 23 @entity0 , isthmic aorto-aortic inlay graft interposition in 5 @entity0 , aorto-aortic bypass in 2 @entity0 , subclavio-aortic bypass in 2 @entity0 , graft patch plasty in one @entity0 and ilio-renal bypass in one @entity0 . Complications included severe @entity3 in one @entity0 and pneumothorax in one @entity0 . No early or late mortality occurred. CONCLUSIONS: The authors conclude that life long control is mandatory in order to detect late complications in @entity0 who underwent operation of @entity4 in childhood.

title: [Late complications and treatment options of XXXX operated in childhood].

answer: @entity4


abstract: OBJECTIVE: The @entity3 , (MetS) a global epidemic, is a state of low grade chronic @entity2 and confers an increased risk for @entity1 and CVD. We have previously reported increased activity of the pathogen recognition receptors, Toll-like receptors (TLRs), @entity9 and @entity10 in MetS. We hypothesized that increased TLR activity in MetS is due in part to increased levels of circulating PAMP-binding proteins, soluble @entity11 (sCD14), @entity12 ( @entity12 ) and the damage associated molecular pattern (DAMP), @entity5 ( @entity5 ). METHODS: We measured sCD14, @entity12 and @entity5 in fasting plasma from nascent MetS (n  =  37) and healthy control subjects (n  =  32) by ELISA. We also investigated the effects of sCD14 and @entity12 on @entity10 activity in @entity0 aortic endothelial cells (HAECs). RESULTS: Following adjustment for body mass index and waist circumference, sCD14, @entity12 and @entity5 levels remained significantly increased in MetS. Also their levels increased with increasing numbers of MetS risk factors. Only sCD14 correlated significantly with monocyte @entity10 protein and activity. None of these soluble biomarkers correlated with @entity9 protein. Both sCD14 and @entity5 correlated significantly with HOMA-IR. In @entity6 primed HAECs, sCD14 compared to @entity12 , resulted in a greater increase in both @entity10 abundance and inflammatory biomediators (NF-kB, @entity8 , @entity7 and @entity4 ). CONCLUSION: Thus, we make the novel observation that sCD14 reflects increased monocyte @entity10 protein and activity in nascent MetS and by contributing to @entity2 could explain, in part, the increased risk for @entity1 and CVD.

title: Circulating pathogen associated molecular pattern - binding proteins and XXXX in nascent @entity3 : implications for cellular Toll-like receptor activity.

answer: @entity5


abstract: OBJECTIVE: The @entity3 , (MetS) a global epidemic, is a state of low grade chronic @entity2 and confers an increased risk for @entity1 and CVD. We have previously reported increased activity of the pathogen recognition receptors, Toll-like receptors (TLRs), @entity9 and @entity10 in MetS. We hypothesized that increased TLR activity in MetS is due in part to increased levels of circulating PAMP-binding proteins, soluble @entity11 (sCD14), @entity12 ( @entity12 ) and the damage associated molecular pattern (DAMP), @entity5 ( @entity5 ). METHODS: We measured sCD14, @entity12 and @entity5 in fasting plasma from nascent MetS (n  =  37) and healthy control subjects (n  =  32) by ELISA. We also investigated the effects of sCD14 and @entity12 on @entity10 activity in @entity0 aortic endothelial cells (HAECs). RESULTS: Following adjustment for body mass index and waist circumference, sCD14, @entity12 and @entity5 levels remained significantly increased in MetS. Also their levels increased with increasing numbers of MetS risk factors. Only sCD14 correlated significantly with monocyte @entity10 protein and activity. None of these soluble biomarkers correlated with @entity9 protein. Both sCD14 and @entity5 correlated significantly with HOMA-IR. In @entity6 primed HAECs, sCD14 compared to @entity12 , resulted in a greater increase in both @entity10 abundance and inflammatory biomediators (NF-kB, @entity8 , @entity7 and @entity4 ). CONCLUSION: Thus, we make the novel observation that sCD14 reflects increased monocyte @entity10 protein and activity in nascent MetS and by contributing to @entity2 could explain, in part, the increased risk for @entity1 and CVD.

title: Circulating pathogen associated molecular pattern - binding proteins and @entity5 in nascent XXXX : implications for cellular Toll-like receptor activity.

answer: @entity3


abstract: OBJECTIVE: The Scales for Outcomes in @entity2 (SCOPA-AUT) questionnaire was used to assess @entity4 in @entity0 with @entity1 . The aim of this study was to evaluate the reliability of the Japanese version of the SCOPA-AUT. METHODS: We translated the SCOPA-AUT from English to Japanese. Thirty-one @entity0 with diseases involving autonomic symptoms completed the form twice. The reliability was assessed by Cronbach's coefficient alphas and intraclass correlation coefficients (ICCs). RESULTS: The average (standard deviation, SD) total scores of the first and second assessments of the SCOPA-AUT were 15.7 (SD, 7.1) and 13.6 (SD, 6.5), respectively. The Cronbach's coefficient alphas were globally high, but the ICCs were moderately high. The valid response rates for the questions about @entity3 were 36.7% in @entity0 and 26.6% in @entity0 . CONCLUSIONS: The Japanese version of the SCOPA-AUT had high internal consistency. However, the questions about @entity3 showed less valid response rates.

title: Reliability of the Japanese version of the scales for outcomes in XXXX questionnaire.

answer: @entity2


abstract: OBJECTIVE: To evaluate resource use and outcomes of @entity4 in @entity0 with and without preexisting @entity3 via a national cohort. STUDY DESIGN: @entity0 <19 years of age hospitalized from 2004 to 2010 with @entity4 at 37 centers in the Pediatric Health Information Systems database were included. We excluded @entity0 primarily hospitalized for chronic medical conditions. We used regression analysis to evaluate factors associated with poor outcomes (defined as mortality, mechanical cardiac support, or @entity1 ). RESULTS: There were 1033 cases of @entity4 , of which 663 had @entity3 and 370 did not. Compared with the group without @entity3 , @entity4 in the cohort with @entity3 occurred at younger age, was more commonly attributable to streptococcus, was more likely to require cardiac surgery for @entity4 , and was associated with a lower risk of @entity1 . Mortality was 6.7% (n = 45) and 3.5% (n = 13) in groups with and without @entity3 , respectively. Factors associated with poor outcome in the cohort with @entity3 included greater risk of mortality score ( @entity6 ), mechanical ventilation (OR 3.1), use of antiarrhythmics (OR 2.7), and use of vasoactive medications ( @entity5 ). In the cohort without @entity3 , factors associated with poor outcome included @entity2 (OR 19.3), greater risk of mortality score (OR 4.2), use of antiarrhythmics ( @entity5 ), and mechanical ventilation (OR 2.2). Median charge of hospitalization was  131,893 in the group without @entity3 and  140,655 in the group with @entity3 . CONCLUSION: @entity4 remains a significant cause of morbidity, mortality, and resource use particularly in @entity0 with @entity3 .

title: Resource utilization and outcomes of XXXX in @entity0 .

answer: @entity4


abstract: OBJECTIVE: To evaluate resource use and outcomes of @entity4 in @entity0 with and without preexisting @entity3 via a national cohort. STUDY DESIGN: @entity0 <19 years of age hospitalized from 2004 to 2010 with @entity4 at 37 centers in the Pediatric Health Information Systems database were included. We excluded @entity0 primarily hospitalized for chronic medical conditions. We used regression analysis to evaluate factors associated with poor outcomes (defined as mortality, mechanical cardiac support, or @entity1 ). RESULTS: There were 1033 cases of @entity4 , of which 663 had @entity3 and 370 did not. Compared with the group without @entity3 , @entity4 in the cohort with @entity3 occurred at younger age, was more commonly attributable to streptococcus, was more likely to require cardiac surgery for @entity4 , and was associated with a lower risk of @entity1 . Mortality was 6.7% (n = 45) and 3.5% (n = 13) in groups with and without @entity3 , respectively. Factors associated with poor outcome in the cohort with @entity3 included greater risk of mortality score ( @entity6 ), mechanical ventilation (OR 3.1), use of antiarrhythmics (OR 2.7), and use of vasoactive medications ( @entity5 ). In the cohort without @entity3 , factors associated with poor outcome included @entity2 (OR 19.3), greater risk of mortality score (OR 4.2), use of antiarrhythmics ( @entity5 ), and mechanical ventilation (OR 2.2). Median charge of hospitalization was  131,893 in the group without @entity3 and  140,655 in the group with @entity3 . CONCLUSION: @entity4 remains a significant cause of morbidity, mortality, and resource use particularly in @entity0 with @entity3 .

title: Resource utilization and outcomes of @entity4 in XXXX .

answer: @entity0


abstract: PURPOSE: This study aimed to assess outcomes of liver transplantation (LTx) in @entity0 with @entity5 ( @entity5 ). METHODS: The Kasai procedure was performed for 358 @entity0 at Tohoku University Hospital between January 1955 and December 2013; 64 (17.9%) required LTx. These 64 @entity0 were divided into 4 groups according to their age at the time of transplantation: Group 1, aged <2 years (n = 27); Group 2, aged 2-9 years (n = 16); Group 3, aged 10-19 years (n = 11); and Group 4, aged >= 20 years (n = 10). Clinical parameters were evaluated retrospectively. RESULTS: Both living-donor (n = 57) and deceased-donor (n = 7) LTx were performed. Indications were irreversible @entity4 (n = 53), intractable @entity2 (n = 3), @entity6 (n = 6), portopulmonary @entity1 (n = 1), and intestinal @entity3 (n = 1). @entity4 occurred more frequently in Groups 1 and 2 than in Groups 3 and 4 (p = 0.031). Survival rates were 81.5, 100, 90.9, and 80% in Groups 1, 2, 3, and 4, respectively. CONCLUSION: Although the overall LTx survival rate was satisfactory, some adult recipients experienced LTx-related difficulty. Close follow-up, meticulous assessment of physical and social conditions, presence of a multidisciplinary support system, and appropriate time course for LTx are all essential factors in the treatment of @entity5 .

title: Liver transplantation following the Kasai procedure in treatment of XXXX : a single institution analysis.

answer: @entity5


abstract: The radioallergosorbent test (RAST) has been used for in vitro diagnosis of @entity3 in a selected group of @entity0 with @entity2 and @entity1 . The results were compared with those of provocation tests and also with the results of skin tests. Where the results of RAST and the provocation tests differed, repeated tests were performed, initially in vitro and secondly in vivo. Selected commercial allergens of good quality were used and, for the most part, the same allergen batches were used in RAST, in the provocation tests and in the skin tests. A 76% correlation between RAST and provocation tests was found on preliminary investigation before divergent results were repeated. This degree of correlation is similar to that obtained previously in unselected @entity0 using RAST as a part of the routine diagnostic. On repeated examination, agreement was obtained in an additional 16% of the cases. The major part of the improvement (13%) was due to conversion of preliminary RAST results from negative to positive in @entity0 with positive provocation tests. To a minor extent, the improvement was due to the fact that in, some @entity0 with positive RAST, negative provocation tests became positive when repeated. Finally, in one case an originally positive RAST in a @entity0 with a negative provocation test was found to be negative on re-examination. Comparing the final revised results of RAST and provocation tests there were no cases where a negative provocation test was combined with a positive RAST. Nearly all the @entity0 with positive provocation tests in spite of a negative RAST were shown to have low degree @entity3 . Although circulating reaginic antibodies are not always present, it seems that, on repeated investigations, the great majority of @entity0 with @entity2 and @entity4 can be shown to have such antibodies even though the serum concentration may be low or very low. In doubtful cases repeated RAST examinations may be of value.

title: In vitro diagnosis of XXXX . V. The value of repeated testing using several batches of the allergen extract.

answer: @entity3


abstract: Extracellular and bacterial factors that influence the phagocytosis and killing of staphylococci by @entity0 polymorphonuclear leukocytes have been studied. @entity2 strains were, in general, more rapidly phagocytized than were @entity1 strains. However, two strains of @entity2 had a very slow rate of ingestion. Although the rate of phagocytosis of @entity1 Wood 46 was greater than that of @entity1 502A, the Wood 46 strain was more difficult to kill. Serum was essential for phagocytosis of both @entity1 and @entity2 . The opsonic titer of pooled serum was similar for @entity1 and @entity2 . In normal pooled serum, heat-labile factors were more important for effective phagocytosis than they were in immune serum. Although a saturation point for ingestion was reached, the percentage of ingested bacteria that remained alive within the leukocyte remained relatively fixed. Heat-killed and live staphylococci were igested in a similar fashion. The rate of phagocytosis was greatly reduced at 41 degrees C.

title: Extracellular and bacterial factors influencing staphylococcal phagocytosis and killing by XXXX polymorphonuclear leukocytes.

answer: @entity0


abstract: Mechanical @entity5 was produced in 36 @entity2 with a fluid-percussion model in which @entity1 is produced by a single, brief, hydraulically-induced pressure transient that is conducted through the brain. Fluid-percussion injury induce elastic deformation of the brain resembling the @entity1 known to occur following head impact. Physiological responses and pahtological changes following injury were expressed as a function of peak pressure. Macroscopic central nervous system lesions concentrated at the pontomesencephalic junction, cervicomedullary junction, and in the cerebellar tonsils were consistently observed at and above 2.6 atmospheres (atm). At higher levels of injury (greater than or equal to 3.2 atm) there was extensive basal @entity3 . At very high levels of injury (greater than 4.0 atm) hemorrhagic contusions were noted at the cerebral hemisphere impact site. A spectrum of neuronal alterations was identified in the damaged areas. Computer analysis showed correlation of electroencephalographic (EEG) changes with the neuropathological changes, since EEG recovery became severely @entity0 .6 atm. No EEG changes were noted below 1.5 atm. From 1.5 to 2.2 atm there was a physiological response to injury but no significant changes were seen on neuropathological examination. This range of injury should permit further studies of the more subtle changes following mechanical @entity5 without intraparenchymal @entity4 or @entity3 . The fluid-percussion model relates @entity1 following mechanical loading to a single pressure transient that is easily measured and controlled. Further quantitative investigation into the pathobiology of mechanical @entity5 following graded @entity1 is thus made possible.

title: Fluid-percussion model of mechanical XXXX in the cat.

answer: @entity5


abstract: The belief that the smooth muscle contracting activity of angiotensin II (angiotensin) in the @entity1 ileum is partly mediated by release of @entity2 was reexamined, with the following results. 1. @entity6 did not reduce the maximum contraction produced by angiotensin, although it caused a shift to the right of the log dose-response curve (dose ratio = 2.2). A similar shift was observed with @entity0 , @entity4 and @entity8 . 2. A moderate potentiation of angiotensin by @entity5 was also observed, which was similarly found for the other agonists. 3. A previous report that @entity6 blocks the fast (phasic) component of the isometric response of the ileum to angiotensin was not confirmed. The disappearance of the phasic component was found to be due to a tachyphylactic change in the response. 4. Depolarization by high doses of @entity3 , and inhibition of @entity2 synthesis by @entity7 , did not affect the response to angiotensin. 5. Ilei in which the intramural ganglia had been destroyed by incubation at 4 degrees 48-56 h responed maximally to angiotensin, without loss of the phasic component of the response. It is concluded that the available evidence does not support the participation of a cholinergic mechanism in the effect of angiotensin upon the @entity1 ileum.

title: Evidence against cholinergic mediation of the effect of angiotensin II on the XXXX ileum.

answer: @entity1


abstract: 1. Allantoinase [EC 3.5.2.5] was isolated from cells of Candida utilis and unpurified by chromatography on columns of DEAE-cellulose and Sephadex G-200 after treatment with @entity3 to remove @entity1 oxidase [EC 1.7.3.3.]. 2. The purified allantoinase catalyzed the hydrolysis of @entity4 into @entity5 . However, only half of the @entity4 produced from @entity1 by @entity1 oxidase was converted. The rest of the @entity4 was unchanged, and showed a negative @entity2 . 3. On the other hand, the combined action of crude @entity1 oxidase and allantoinase resulted in nearly complete conversion of @entity1 into @entity5 . Furthermore, the unpurified allantoinase preparation hydrolyzed racemic @entity4 to @entity5 completely. 4. These results indicate that the @entity1 oxidase produces racemic @entity4 from @entity1 and that the allantoinase attacks only @entity4 of positive @entity2 . The results also suggest that @entity4 racemase is present in the @entity0 cells.

title: Stereospecificity of conversion of XXXX into @entity5 by enzymes of Canadida utilis.

answer: @entity1


abstract: 1. Allantoinase [EC 3.5.2.5] was isolated from cells of Candida utilis and unpurified by chromatography on columns of DEAE-cellulose and Sephadex G-200 after treatment with @entity3 to remove @entity1 oxidase [EC 1.7.3.3.]. 2. The purified allantoinase catalyzed the hydrolysis of @entity4 into @entity5 . However, only half of the @entity4 produced from @entity1 by @entity1 oxidase was converted. The rest of the @entity4 was unchanged, and showed a negative @entity2 . 3. On the other hand, the combined action of crude @entity1 oxidase and allantoinase resulted in nearly complete conversion of @entity1 into @entity5 . Furthermore, the unpurified allantoinase preparation hydrolyzed racemic @entity4 to @entity5 completely. 4. These results indicate that the @entity1 oxidase produces racemic @entity4 from @entity1 and that the allantoinase attacks only @entity4 of positive @entity2 . The results also suggest that @entity4 racemase is present in the @entity0 cells.

title: Stereospecificity of conversion of @entity1 into XXXX by enzymes of Canadida utilis.

answer: @entity5


abstract: A @entity0 with non-contributory family history, at the age of 7 years developed a recurrent @entity3 followed by @entity4 and @entity2 . She died in a decerebrate state at the age of 10 9/12 years. Diffuse EEG abnormalities changed in accordance with the clinical course. CSF findings were always negative. Brain biopsy performed at the age of 9 5/12 years was non-diagnostic. No clinical signs of @entity5 were present. Neuropathological examination disclosed severe @entity1 of the cerebral white matter with formation of large periventricular cavities, relative sparing of the subcortical arcuate fibers, and peripheral myelin breakdown of the orthochromatic (neutral fat) type. There was complete absence of inflammatory lesions, comparative preservation of axons and oligodendroglia with moderate astroglial reaction. The optic system and cerebellum were not involved. Additional postanoxic changes were seen in the thalamus and hippocampus. The sporadic case is suggested to represent a cavitating form of @entity8 which is to be separated from Schilder's @entity6 and @entity7 . The etiology of the disorder is unknown.

title: [Cavitating neutral fat XXXX with recurrent course].

answer: @entity8


abstract: The acute effects of the @entity10 ( @entity9 ) mixture ( @entity13 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity0 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity10 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity10 treatment resulted in a six-fold increase in amount of @entity7 . Activities of @entity6 -cytochrome c reductase, @entity11 demethylase and @entity12 diphosphatase were increased whereas @entity4 -6-phosphatase values were decreased by @entity10 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity10 -exposed animals. Phospholipids, @entity1 and @entity3 were significantly increased after @entity10 exposure; however, the greatest percentage increase was seen in the @entity3 pool. The finding of an increase in microsomal @entity3 to phospholipid ratios with exposure to @entity10 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity5 indicated that the @entity10 -induced @entity8 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity2 into microsomal membrane and albumin was somewhat enhanced in @entity0 exposed to @entity10 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity10 -induced @entity8 .

title: Studies on the cellular toxicity of XXXX ( @entity9 ). I. Effect of @entity9 on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity0 liver- a morphological and biochemical study.

answer: @entity9


abstract: The acute effects of the @entity10 ( @entity9 ) mixture ( @entity13 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity0 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity10 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity10 treatment resulted in a six-fold increase in amount of @entity7 . Activities of @entity6 -cytochrome c reductase, @entity11 demethylase and @entity12 diphosphatase were increased whereas @entity4 -6-phosphatase values were decreased by @entity10 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity10 -exposed animals. Phospholipids, @entity1 and @entity3 were significantly increased after @entity10 exposure; however, the greatest percentage increase was seen in the @entity3 pool. The finding of an increase in microsomal @entity3 to phospholipid ratios with exposure to @entity10 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity5 indicated that the @entity10 -induced @entity8 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity2 into microsomal membrane and albumin was somewhat enhanced in @entity0 exposed to @entity10 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity10 -induced @entity8 .

title: Studies on the cellular toxicity of @entity9 ( XXXX ). I. Effect of @entity9 on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity0 liver- a morphological and biochemical study.

answer: @entity9


abstract: The acute effects of the @entity10 ( @entity9 ) mixture ( @entity13 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity0 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity10 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity10 treatment resulted in a six-fold increase in amount of @entity7 . Activities of @entity6 -cytochrome c reductase, @entity11 demethylase and @entity12 diphosphatase were increased whereas @entity4 -6-phosphatase values were decreased by @entity10 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity10 -exposed animals. Phospholipids, @entity1 and @entity3 were significantly increased after @entity10 exposure; however, the greatest percentage increase was seen in the @entity3 pool. The finding of an increase in microsomal @entity3 to phospholipid ratios with exposure to @entity10 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity5 indicated that the @entity10 -induced @entity8 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity2 into microsomal membrane and albumin was somewhat enhanced in @entity0 exposed to @entity10 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity10 -induced @entity8 .

title: Studies on the cellular toxicity of @entity9 ( @entity9 ). I. Effect of XXXX on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity0 liver- a morphological and biochemical study.

answer: @entity9


abstract: The acute effects of the @entity10 ( @entity9 ) mixture ( @entity13 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity0 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity10 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity10 treatment resulted in a six-fold increase in amount of @entity7 . Activities of @entity6 -cytochrome c reductase, @entity11 demethylase and @entity12 diphosphatase were increased whereas @entity4 -6-phosphatase values were decreased by @entity10 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity10 -exposed animals. Phospholipids, @entity1 and @entity3 were significantly increased after @entity10 exposure; however, the greatest percentage increase was seen in the @entity3 pool. The finding of an increase in microsomal @entity3 to phospholipid ratios with exposure to @entity10 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity5 indicated that the @entity10 -induced @entity8 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity2 into microsomal membrane and albumin was somewhat enhanced in @entity0 exposed to @entity10 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity10 -induced @entity8 .

title: Studies on the cellular toxicity of @entity9 ( @entity9 ). I. Effect of @entity9 on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of XXXX liver- a morphological and biochemical study.

answer: @entity0


abstract: This paper describes 3 @entity0 with a severe, generalized @entity3 with short limbs, shortness of stature, relative @entity5 and neonatal @entity1 in all cases, @entity4 in two and dislocation of lenses in one. They died at 7 and 10 weeks and at 17 months respectively. No autopsy was performed on any of the 3 @entity0 . Roentgenological manifestations include short, broad tubular bones with metaphyseal widening, @entity6 , thigh and forearm bones, neonatal accelerated carpal bone maturation, short, broad pelvis with wide, flared iliac wings, many gross @entity2 including most prominently coronal clefts of almost any vertebral body, and short ribs with flared anterior ends. Roentgenographically the condition has some similarities with @entity7 , or more correctly, the @entity7 . However, we think that the clinical and roentgenological manifestations are sufficiently unique to permit delineation of the condition of our 3 @entity0 as a "new" entity different from the @entity7 . Similar cases have been described by Rolland et al. from France and by Dinno et al. from the U.S.A. The later case and our 3 @entity0 were sporadic cases, but the former had a probably affected sibling, suggesting that this disorder is an autosomal recessive trait.

title: A severe XXXX which resembles @entity7 .

answer: @entity3


abstract: This paper describes 3 @entity0 with a severe, generalized @entity3 with short limbs, shortness of stature, relative @entity5 and neonatal @entity1 in all cases, @entity4 in two and dislocation of lenses in one. They died at 7 and 10 weeks and at 17 months respectively. No autopsy was performed on any of the 3 @entity0 . Roentgenological manifestations include short, broad tubular bones with metaphyseal widening, @entity6 , thigh and forearm bones, neonatal accelerated carpal bone maturation, short, broad pelvis with wide, flared iliac wings, many gross @entity2 including most prominently coronal clefts of almost any vertebral body, and short ribs with flared anterior ends. Roentgenographically the condition has some similarities with @entity7 , or more correctly, the @entity7 . However, we think that the clinical and roentgenological manifestations are sufficiently unique to permit delineation of the condition of our 3 @entity0 as a "new" entity different from the @entity7 . Similar cases have been described by Rolland et al. from France and by Dinno et al. from the U.S.A. The later case and our 3 @entity0 were sporadic cases, but the former had a probably affected sibling, suggesting that this disorder is an autosomal recessive trait.

title: A severe @entity3 which resembles XXXX .

answer: @entity7


abstract: Antitussive activity and some other related pharmacological properties of @entity10 were studied. Toxic symptoms in @entity0 and @entity4 were due to the CNS excitation. Acute @entity3 of (AT-17) in @entity0 was slightly (s.c.) or far (p.o.) weaker than that of @entity8 , but it was three times as toxic as @entity8 in @entity4 (i.v.). Antitussive efficacy was about 40% of that of @entity8 in @entity4 , whereas 77% as potent as @entity8 in @entity5 . It showed no relaxing effect on the bronchial muscle of @entity6 in either normal tone or @entity2 -induced @entity7 . It had analgesic effect 1/3 as potent as @entity8 in @entity0 but it was not antagonized by @entity9 . The prolongation of hexobarbital sleeping time by AT-17 was similar extent to that by @entity8 . Anti-electroshock effect was half as potent as that of @entity1 . The inhibitory effect on the transportation of intestinal contents in @entity0 was far weaker than that of @entity8 . Effect on the respiratory and circulatory systems were also investigated.

title: Antitussive activity and other related pharmacological properties of XXXX (AT-17).

answer: @entity10


abstract: The effect of microelectrophoretically and systemically applied opiates on neuronal discharge activity in the sensorimotor cortex of naive and @entity2 tolerant/dependent @entity0 has been studied. In naive @entity0 depression of spontaneous discharge activity was the predominant effect of low doses of phoretically applied @entity2 . Higher doses and repeated application frequently converted this effect into excitation. Only the depressant effect was antagonised by @entity3 . @entity3 itself had no effect on spontaneous discharge activity when applied at dose-levels sufficient to antagonise the depressant effect of @entity2 . @entity8 mimicked the action of @entity2 whereas @entity6 was inactive. @entity2 depressed the excitatory action of @entity7 and of @entity1 by a @entity3 -antagonisable mechanism. Systemic application of @entity5 mimicked the inhibitory effect of phoretically applied @entity2 upon transcallosally evoked discharge activity. The late response was markedly depressed whereas the primary response was little affected. Phoretically applied @entity3 antagonised the effects of systemically applied @entity5 . In chronically morphinised @entity0 the depressant effect of microelectrophoretically administered @entity2 was almost lacking and a @entity3 -resistant excitation became the predominant effect. In these animals the excitant effect of @entity3 was also increased and the anti- @entity4 effect and the anti- @entity1 effect of @entity2 was abolished. The present data speak in favour of a postsynaptically located stereospecific receptor which mediates the inhibitory effects of opiates and which may be involved in the development of acute and chronic tolerance to these drugs.

title: Actions of opiates upon single unit activity in the cortex of naive and tolerant XXXX .

answer: @entity0


abstract: Severe @entity1 causes a deterioration in cardiopulmonary function. The effect of surgical correction on this is variable. We studied the forced vital capacity [FVC) and forced expiratory volume in one second (FEV1) before and after surgical correction in 30 adolescents with @entity2 and the results are expressed as a percentage of the predicted normal values using 101 @entity0 as controls. A negative correlation was noted preoperatively between the magnitude of the curve and FVC and FEV1. Surgical correction of the curve was done with a Harrington rod in 17 @entity0 followed by cast and brace immobilisation for one and a half years. In the remaining 13 @entity0 the Harrington rod was supplemented with sublaminar wires (SSI) to eliminate the use of an orthoses. All @entity0 had a posterior spinal fusion. Our study showed that there was an improvement in the spirometric values post-operatively but this was not statistically significant. This improvement was similar in both groups of @entity0 . Further studies, for a longer period and of other indices of pulmonary function are required.

title: Spirometric pulmonary function tests before and after surgical correction of XXXX in adolescents.

answer: @entity2


abstract: UNASSIGNED:     Introduction: This study was carried out to examine whether or not elderly @entity0 on @entity2 ( @entity2 ) had an increased risk of @entity2 .     Methods: This was a retrospective cohort study based on data from the French Language Peritoneal Dialysis Registry. We analyzed 8,396 incident @entity0 starting @entity2 between January 2003 and December 2010. The end of the observation period was 31 December 2012. @entity0 were separated into 2 age groups: up to 75 and over of 75 years old.     Results: Among 8,396 @entity0 starting dialysis there were 3,173 @entity0 older than 75. When using a Cox model, no association was found between age greater than 75 years and increased risk of @entity2 (hazard ratio [HR]: 0.97 [0.88 - 1.07]). @entity1 (HR: 1.14 [1.01 - 1.28] and continuous ambulatory @entity2 (HR: 1.13 [1.04 - 1.23]) were significantly associated with a higher risk of @entity2 whereas nurse-assisted @entity2 was associated with a lower risk of @entity2 (HR: 0.85 [0.78 - 0.94]. In the analysis restricted to the 3,840 self-care @entity2 @entity0 , there was no association between age older than 75 years and risk of @entity2 .     Conclusion: The risk of @entity2 is not increased in elderly @entity0 on @entity2 in a country where assisted @entity2 is available.

title: IS PERITONITIS RISK INCREASED IN ELDERLY XXXX ON PERITONEAL DIALYSIS? REPORT FROM THE FRENCH LANGUAGE PERITONEAL DIALYSIS REGISTRY (RDPLF).

answer: @entity0


abstract: Allergen-specific @entity5 ( @entity5 ) reactions lead to acute degranulation of mast cells and basophils and release of stored mediators, particularly tryptase and @entity2 , which can be measured in vitro after reactions. The aim of this study was to investigate the utility of serum tryptase and plasma @entity2 during @entity3 ( @entity3 ) in 103 @entity0 with suspected @entity4 , in order to support the diagnosis of a @entity5 -mediated reaction. Blood samples for serum tryptase and plasma @entity2 were collected before the @entity3 and after the onset of @entity1 or after 60 minutes from test completion. Serum tryptase and plasma @entity2 were measured by a fluoroenzyme immunoassay (ImmunoCAP; ThermoFisher, Uppsala, Sweden) according to the manufacturer  s instructions. A correlation between serum tryptase and plasma @entity2 distributions was observed after @entity3 (p=0.0035). A correlation was also observed for both serum tryptase and plasma @entity2 before and after @entity3 (p less than0.0001). Subjects with positive response to @entity3 had significantly higher values (p = 0.0375) of serum tryptase compared to subjects with negative response. The plasma @entity2 distribution showed a significant difference between measurements before and after @entity3 , both in the complete population (p less than 0.0001), and considering the response (negative @entity3 : p less than 0.0001; positive @entity3 : p=0.0181). The diagnostic work-up of @entity5 - mediated @entity4 may include determination of serum tryptase and plasma @entity2 , in order to support the results of @entity3 . These markers are strongly related to the same @entity5 -mediated mechanism and, as they can be both easily measured, can confirm the allergic nature of a reaction in the real-life setting of @entity4 .

title: TRYPTASE AND XXXX MAY SUPPORT ORAL FOOD CHALLENGE IN THE DIAGNOSIS OF ALLERGY.

answer: @entity2


abstract: OPINION STATEMENT: Approximately 10  % of cases of @entity7 ( @entity7 ) harbor a MYC rearrangement and this has been associated with an inferior outcome following standard therapy across many different studies. Double-hit and triple-hit @entity4 harbor concurrent rearrangements of MYC and @entity2 and/or @entity10 and are also associated with a very aggressive course and poor clinical outcome. It is unclear and there is lack of consensus on how these diseases should be approached therapeutically. They are characterized typically by high tumor proliferation and likely require @entity8 -type strategies and several retrospective studies suggest that more intensive approaches than rituximab, @entity5 , @entity3 , @entity6 , and @entity1 (R- @entity9 ) may be beneficial. One challenge in this respect is that most @entity0 with these diseases are older than 60  years and generally have poor tolerability of regimens typically used in @entity8 . Dose-adjusted EPOCH-R is an alternative effective immunochemotherapy platform for @entity7 and is effective in @entity8 , and retrospective studies suggest that it is effective and feasible in @entity0 with @entity7 that harbors a MYC rearrangement with or without a @entity2 translocation (double-hit). A multicenter study of this approach in MYC-rearranged @entity7 is ongoing and preliminary results are very encouraging. There is a lack of consensus on the role of consolidation stem cell transplantation in @entity0 who achieve a good response to initial therapy but at this point in time, no (retrospective) studies have demonstrated any benefit. These diseases are also associated with a high rate of CNS involvement and progression and checking for cerebrospinal fluid by cytology and flow cytometry at initial diagnosis should be considered. In summary, based on retrospective data and preliminary prospective data (as more mature data is awaited), while Burkitt-type regimens may be feasible in young @entity0 , DA-EPOCH-R is a reasonable approach for @entity0 with these diseases, particularly for those over the age of 60  years. CNS prophylaxis is a reasonable consideration (depending on clinical characteristics) given that the rate of CNS progression is high. Many exciting new small molecule inhibitors such as @entity2 and MYC inhibitors are in development and are exciting for these diseases and attempts are underway to combine them with effective immunochemotherapy platforms.

title: XXXX : Optimal Therapy for MYC-positive, Double-Hit, and Triple-Hit @entity7 .

answer: @entity7


abstract: OPINION STATEMENT: Approximately 10  % of cases of @entity7 ( @entity7 ) harbor a MYC rearrangement and this has been associated with an inferior outcome following standard therapy across many different studies. Double-hit and triple-hit @entity4 harbor concurrent rearrangements of MYC and @entity2 and/or @entity10 and are also associated with a very aggressive course and poor clinical outcome. It is unclear and there is lack of consensus on how these diseases should be approached therapeutically. They are characterized typically by high tumor proliferation and likely require @entity8 -type strategies and several retrospective studies suggest that more intensive approaches than rituximab, @entity5 , @entity3 , @entity6 , and @entity1 (R- @entity9 ) may be beneficial. One challenge in this respect is that most @entity0 with these diseases are older than 60  years and generally have poor tolerability of regimens typically used in @entity8 . Dose-adjusted EPOCH-R is an alternative effective immunochemotherapy platform for @entity7 and is effective in @entity8 , and retrospective studies suggest that it is effective and feasible in @entity0 with @entity7 that harbors a MYC rearrangement with or without a @entity2 translocation (double-hit). A multicenter study of this approach in MYC-rearranged @entity7 is ongoing and preliminary results are very encouraging. There is a lack of consensus on the role of consolidation stem cell transplantation in @entity0 who achieve a good response to initial therapy but at this point in time, no (retrospective) studies have demonstrated any benefit. These diseases are also associated with a high rate of CNS involvement and progression and checking for cerebrospinal fluid by cytology and flow cytometry at initial diagnosis should be considered. In summary, based on retrospective data and preliminary prospective data (as more mature data is awaited), while Burkitt-type regimens may be feasible in young @entity0 , DA-EPOCH-R is a reasonable approach for @entity0 with these diseases, particularly for those over the age of 60  years. CNS prophylaxis is a reasonable consideration (depending on clinical characteristics) given that the rate of CNS progression is high. Many exciting new small molecule inhibitors such as @entity2 and MYC inhibitors are in development and are exciting for these diseases and attempts are underway to combine them with effective immunochemotherapy platforms.

title: @entity7 : Optimal Therapy for MYC-positive, Double-Hit, and Triple-Hit XXXX .

answer: @entity7


abstract: OBJECTIVES: CT-guided @entity3 -mediated renal sympathetic denervation in treatment of therapy-resistant @entity1 was performed to assess @entity0 safety and collect preliminary data on treatment efficacy. MATERIALS AND METHODS: Eleven @entity0 with therapy-resistant @entity1 (blood pressure of >160  mmHg despite three different antihypertensive drugs including a diuretic) and following screening for secondary causes were enrolled in a phase II single arm open label pilot trial of CT-guided neurolysis of sympathetic renal innervation. Primary endpoint was safety, and secondary endpoint was a decrease of the mean office as well as 24-h systolic blood pressure in follow-up. Follow-up visits at 4  weeks, 3, and 6  months included 24-h blood pressure assessments, office blood pressure, laboratory values, as well as full clinical and quality of life assessments. RESULTS: No @entity2 >= 3   occurred. Three @entity0 exhibited worsened kidney function in follow-up analyses. When accounting all @entity0 , office systolic blood pressure decreased significantly at all follow-up visits (maximal mean decrease -41.2  mmHg at 3  months). The mean 24-h systolic blood pressure values decreased significantly at 3  months, but not at 6  months (mean: -9.7 and -6.3  mmHg, respectively). Exclusion of five @entity0 who had failed catheter-based endovascular denervation and/or were incompliant for antihypertensive drug intake revealed a more pronounced decrease of 24-h systolic blood pressure (mean: -18.3 and -15.2  mmHg at 3 and 6  months, p  =  0.03 and 0.06). CONCLUSION: CT-guided sympathetic denervation proved to be safe and applicable under various anatomical conditions with more renal arteries and such of small diameter.

title: Renal Sympathetic Denervation by CT-Guided XXXX Injection: A Phase II Pilot Trial of a Novel Technique.

answer: @entity3


abstract: UNASSIGNED: Experience-induced plastic changes in the cerebral cortex are accompanied by alterations in excitatory and inhibitory transmission. Increased excitatory drive, necessary for plasticity, precedes the occurrence of plastic change, while decreased inhibitory signaling often facilitates plasticity. However, an increase of inhibitory interactions was noted in some instances of experience-dependent changes. We previously reported an increase in the number of inhibitory markers in the barrel cortex of @entity0 after fear conditioning engaging vibrissae, observed concurrently with enlargement of the cortical representational area of the row of vibrissae receiving conditioned stimulus (CS). We also observed that an increase of @entity2 level accompanied the conditioning. Here, to find whether unaltered GABAergic signaling is necessary for learning-dependent rewiring in the @entity0 barrel cortex, we locally decreased @entity2 production in the barrel cortex or reduced transmission through GABAA receptors (GABAARs) at the time of the conditioning. Injections of @entity4 ( @entity5 ), an inhibitor of @entity1 decarboxylase (GAD), into the barrel cortex prevented learning-induced enlargement of the conditioned vibrissae representation. A similar effect was observed after injection of @entity3 , an antagonist of GABAARs. At the behavioral level, consistent conditioned response (cessation of head movements in response to CS) was impaired. These results show that appropriate functioning of the GABAergic system is required for both manifestation of functional cortical representation plasticity and for the development of a conditioned response.

title: Learning-Dependent Plasticity of the Barrel Cortex Is Impaired by Restricting XXXX -Ergic Transmission.

answer: @entity2


abstract: We have investigated the SX (X = first- or second-row atom), @entity1 , and @entity2 molecules employing the correlation-consistent (cc), the recently developed polarization-consistent (pc), and three Pople-type basis sets, in conjunction with the B3LYP functional. The results confirmed that the aug-pc basis sets represent a great contribution in terms of cost-benefits. In the case of the B3LYP functional, when employing the aug-pc-3 and aug-pc-4 basis sets, it is possible to obtain results that are of aug-cc-pV(5+d)Z and aug-cc-pV(6+d)Z quality, respectively, at a much lower cost. The estimations obtained employing smaller members of the family are of nearly double-   quality and do not provide reliable results. There is no basis set of quadruple-   quality among the polarized-consistent basis sets, although in terms of composition, the aug-pc-3 basis set is a QZ basis set. A precise estimation of the Kohn-Sham complete basis set (CBS) limit with the aug-pc-X basis sets is too difficult for the B3LYP functional because the    (aug-pc-4, aug-pc-3, aug-pc-2) extrapolation gives the same results as those of the aug-pc-4 basis set. This is in contrast with the results observed for ab initio methodologies for which the largest basis sets provided the best estimation of the CBS limit. In our opinion, the closest results to the B3LYP/CBS limit are expected to be those obtained with a two-point extrapolation employing the aug-cc-pV(X+d)Z (X = 5, 6) basis sets. The results obtained with this extrapolation are very close to those predicted by the    (aug-pc-3, aug-pc-2, aug-pc-1) extrapolation, and that provides a cheaper but more inaccurate alternative to estimate the CBS limit. Minor problems were found for the aug-pc-X basis sets and the B3LYP functional for molecules in which @entity0 is bound to a very electronegative element, such as SO, SF, @entity1 , and @entity2 . For these molecules, the cc basis sets were demonstrated to be more useful. The importance of tight d functions was observed; the total atomization energy of @entity1 employing the cc-pV6Z basis set is 1 kcal/mol lower than that obtained with the aug-cc-pV(6+d)Z basis set.

title: Basis Set Requirements for XXXX Compounds in Density Functional Theory:    a Comparison between Correlation-Consistent, Polarized-Consistent, and Pople-Type Basis Sets.

answer: @entity0


abstract: UNASSIGNED: Subconjunctival injection is a minimally invasive route for gene delivery to ocular tissues, but has traditionally been limited to use in the @entity2 . The accurate ocular distribution of virus has not, however, been previously investigated. Adenovirus is an attractive gene vector as it can deliver large genes and allow for short-term gene expression, but how safe it is when delivered via subconjunctival injection remains to be established. We have characterized the bio-distribution and safety of subconjunctivally administered adenovirus in Brown @entity0 . The bio-distribution and transgene duration of adenovirus carrying luciferase gene (Ad-Luci) at various time intervals were evaluated via bioluminescence imaging after subconjunctival injection. Adenovirus carrying a reporter gene, b-galactosidase (Ad-LacZ) or hrGFP (Ad-hrGFP) was administered subconjunctivally and the viral distribution in various ocular tissues was assessed by histological analysis and quantitative PCR (qPCR). @entity1 was assessed by biochemical and immunohistological analysis with TUNEL stain. Systemic immunogenicity was assessed by measuring serum level of @entity3 via ELISA, 2 hours and 14 days after administration of adenovirus. Retinal function was examined by electroretinography. Subconjunctival injection of Ad-Luci induced luciferase expression in the injected eyes within 24 hours, for at least 64 days. Histological analysis showed adenovirus distributed across anterior and posterior ocular tissues. qPCR demonstrated different amounts of adenovirus in different ocular tissues, with the highest amounts closest to the injection site Unlike the intravenous route, subconjunctivally delivered adenovirus did not elicit any detectable @entity1 or systemic immunogenicity. Retinal function was unaffected by adenovirus irrespective of administration route. In conclusion, an adenoviral vector administered subconjunctivally can infiltrate into different ocular tissues and lead to short-term ocular transgene expression, without causing @entity1 and immune activation. Therefore, subconjunctivally administered adenovirus may be a promising gene delivery approach for managing anterior and @entity4 requiring short-term therapy.

title: Gene Delivery by Subconjunctival Injection of Adenovirus in XXXX : A Study of Local Distribution, Transgene Duration and Safety.

answer: @entity0


abstract: UNASSIGNED: Splice sites (SSs)-short @entity1 sequences flanking introns-are under selection for spliceosome binding, and adhere to consensus sequences. However, non-consensus @entity0 , many of which probably reduce SS performance, are frequent. Little is known about the mechanisms maintaining such apparently suboptimal SSs. Here, we study the correlations between strengths of @entity0 occupying different positions of the same SS. Such correlations may arise due to epistatic interactions between positions (i.e., a situation when the fitness effect of a @entity1 in one position depends on the @entity1 in another position), their evolutionary history, or to other reasons. Within both the intronic and the exonic parts of donor SSs, @entity0 that increase (decrease) SS strength tend to co-occur with other @entity0 increasing (respectively, decreasing) it, consistent with positive epistasis. Between the intronic and exonic parts of donor SSs, the correlations of @entity1 strengths tend to be negative, consistent with negative epistasis. In the course of evolution, substitutions at a donor SS tend to decrease the strength of its exonic part, and either increase or do not change the strength of its intronic part. In acceptor SSs, the situation is more complicated; the correlations between adjacent positions appear to be driven mainly by avoidance of the AG dinucleotide which may cause aberrant splicing. In summary, both the content and the evolution of SSs is shaped by a complex network of interdependences between adjacent @entity0 that respond to a range of sometimes conflicting selective constraints.

title: Correlated Evolution of XXXX Positions within Splice Sites in Mammals.

answer: @entity1


abstract: Preoperative hysteroscopic and histologic findings of @entity1 were compared with postoperative histologic findings of cervices. A total of 132 @entity0 consisting of 72 @entity7 , 16 @entity3 and 44 @entity6 were examined during the 5 years beginning in 1977. The rates of @entity1 observed in the endocervix were 33.3% @entity7 , 56.2% @entity3 and 72.8% @entity6 . The preoperative diagnoses of endocervical lesions were histologically identical with the postoperative ones in 24 (88.9%) of 27 cases of @entity7 , 7 (87.5%) of 8 cases of @entity3 and all of 30 cases of @entity6 . Mosaics and punctations were noticed in the endocervix near the external os in the early stage of @entity1 , whereas white epithelia were observed more frequently and, over a wide range in the endocervix. @entity5 were noticed predominantly in @entity7 . Atypical vessels were recognized mainly in @entity3 . Gross irregular and dilated atypical vessels were recognized mainly in @entity3 . Gross irregular and dilated atypical vessels, @entity4 , irregular surface and @entity2 were observed predominantly in @entity3 . In conclusion, hysteroscopy is useful in detecting @entity1 located in the endocervical canal.

title: Usefulness of hysteroscopy for detection of XXXX in the endocervical canal.

answer: @entity1


abstract: An acute experimental @entity2 was induced in the right knee joint of adult @entity1 anesthetized with @entity4 , and the activity of single fine afferent units of the medial articular nerve was recorded from filaments of the saphenous nerve. All units included in this study were sensitive to local mechanical probing of the medial and anteromedial aspects of the knee joint. The units were identified by their conduction velocity as belonging either to group III (2.5-20 m/s, 48 U) or group IV (less than 2.5 m/s, 29 U). After the identification, the resting activity was measured, and the evoked activity was determined using local mechanical stimulation with glass rods and von Frey hairs, and passive movements of the knee joint. The results were compared with those obtained in a similar study of fine articular units from normal joints. Resting activity was observed in 75% of the group III and 83% of the group IV units. The discharges were irregular and often of high frequency. Both the percentages of units with resting activity and the frequencies of their discharges were more than twice as high as in the control sample. Nearly all units from inflamed joints had low threshold to movements (group III 89%, group IV 72%), and most units responded well to flexion and extension. In contrast, in units from normal joints only 33% of the group III and 10% of the group IV units responded well to passive movements in the normal working range of the joint. In inflamed as well as in normal joints the responses were mostly tonic in character and adapted slowly or not at all when the joint was held in a new position. In normal joints 24% of the group III and 36.5% of the group IV afferent units with local mechanosensitive receptive fields could not be excited by any physiological or noxious joint movements. Such units were only very occasionally seen in the present sample. The average number of receptive fields per unit found in inflamed joints exceeded considerably that in normal units, but no systematic drop in von Frey thresholds was seen when comparing the control sample with the inflamed one. From the above data we conclude that an acute @entity0 sensitizes many fine articular units, making them active at rest and increasing the responsiveness more readily to normally @entity3 . Both nociceptors and units with low threshold to movement seem to become sensitized by the @entity0 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: Effects of an experimental XXXX on the sensory properties of fine articular afferent units.

answer: @entity2


abstract: 1. Very low concentrations of @entity4 decrease the capacity of @entity0 heart mitochondria, oxidizing @entity2 plus @entity3 , to remove @entity1 from the medium. 2. The primary effect is on the rate of @entity1 sequestration; this is reflected in the overall extent of @entity1 removal. 3. @entity4 has at least two separate actions. Below about 0.5 nmol/mg of protein, it acts solely by competing with @entity1 (Ki = 0.4 muM); above this concentration it also inhibits the production or use of respiratory energy, so that at 1 nmol of @entity4 /mg of protein, @entity1 removal is almost completely abolished. 4. @entity4 inhibits coupled and uncoupled respiratory O2 use by mitochondria oxidizing @entity2 plus @entity3 , but at higher concentrations than those that affect @entity1 removal; similar concentrations of @entity4 inhibit @entity2 uptake, but not @entity3 uptake, by the mitochondria. 5. Mg2+ only decreases @entity1 removal by competition, and is a far-less effective competitor than @entity4 (Ki = 0.15 mM). It is possible that the primary cause of the second effect of @entity4 is displacement of membrane Mg2+. 6. The consequences of these results are discussed in terms of the possible involvement of heart mitochondria in excitation-contraction coupling, and the @entity4 levels that might occur in heart tissue in vivo.

title: The effect of lead on the calcium-handling capacity of XXXX heart mitochondria.

answer: @entity0


abstract: BACKGROUND: The impact of local anesthetics on the regulation of @entity3 homeostasis by protein kinase B ( @entity4 ) and @entity7 -activated protein kinase ( @entity15 ) is unclear but important because of the implications for both @entity2 and its reversal by IV lipid emulsion (ILE). METHODS: @entity1 received 10 mg/kg @entity5 over 20 s followed by nothing or 10 ml/kg ILE (or ILE without @entity5 ). At key time points, heart and kidney were excised. Glycogen content and phosphorylation levels of @entity4 , p70 s6 kinase, s6, insulin receptor substrate-1, @entity12 , @entity15 , @entity11 carboxylase, and @entity9 2 were quantified. Three animals received Wortmannin to irreversibly inhibit @entity14 ( @entity14 ) signaling. Isolated heart studies were conducted with @entity5 and @entity8 -a reversible @entity14 inhibitor. RESULTS: @entity5 @entity6 rapidly dephosphorylated @entity4 at S473 to 63    5% of baseline and phosphorylated @entity15 to 151    19%. @entity15 activation inhibited targets downstream of @entity0 target of @entity10 complex 1 via @entity9 2. Feedback dephosphorylation of @entity13 to 31    8% of baseline sensitized @entity4 signaling in hearts resulting in hyperphosphorylation of @entity4 at @entity12 to 390    64% and 293    50% of baseline, respectively. Glycogen accumulated to 142    7% of baseline. Irreversible inhibition of @entity14 upstream of @entity4 exacerbated @entity5 @entity6 , whereas pretreating with a reversible inhibitor delayed the onset of @entity2 . ILE rapidly phosphorylated @entity4 at S473 and T308 to 150    23% and 167    10% of baseline, respectively, but did not interfere with @entity15 or targets of @entity0 target of @entity10 complex 1. CONCLUSION: @entity3 handling by @entity4 and @entity15 is integral to recovery from @entity5 @entity6 and modulation of these pathways by ILE contributes to lipid resuscitation.

title: Insulin Signaling in @entity5 -induced XXXX : Sensitization during Recovery and Potentiation by Lipid Emulsion.

answer: @entity6


abstract: BACKGROUND: The impact of local anesthetics on the regulation of @entity3 homeostasis by protein kinase B ( @entity4 ) and @entity7 -activated protein kinase ( @entity15 ) is unclear but important because of the implications for both @entity2 and its reversal by IV lipid emulsion (ILE). METHODS: @entity1 received 10 mg/kg @entity5 over 20 s followed by nothing or 10 ml/kg ILE (or ILE without @entity5 ). At key time points, heart and kidney were excised. Glycogen content and phosphorylation levels of @entity4 , p70 s6 kinase, s6, insulin receptor substrate-1, @entity12 , @entity15 , @entity11 carboxylase, and @entity9 2 were quantified. Three animals received Wortmannin to irreversibly inhibit @entity14 ( @entity14 ) signaling. Isolated heart studies were conducted with @entity5 and @entity8 -a reversible @entity14 inhibitor. RESULTS: @entity5 @entity6 rapidly dephosphorylated @entity4 at S473 to 63    5% of baseline and phosphorylated @entity15 to 151    19%. @entity15 activation inhibited targets downstream of @entity0 target of @entity10 complex 1 via @entity9 2. Feedback dephosphorylation of @entity13 to 31    8% of baseline sensitized @entity4 signaling in hearts resulting in hyperphosphorylation of @entity4 at @entity12 to 390    64% and 293    50% of baseline, respectively. Glycogen accumulated to 142    7% of baseline. Irreversible inhibition of @entity14 upstream of @entity4 exacerbated @entity5 @entity6 , whereas pretreating with a reversible inhibitor delayed the onset of @entity2 . ILE rapidly phosphorylated @entity4 at S473 and T308 to 150    23% and 167    10% of baseline, respectively, but did not interfere with @entity15 or targets of @entity0 target of @entity10 complex 1. CONCLUSION: @entity3 handling by @entity4 and @entity15 is integral to recovery from @entity5 @entity6 and modulation of these pathways by ILE contributes to lipid resuscitation.

title: Insulin Signaling in XXXX -induced @entity6 : Sensitization during Recovery and Potentiation by Lipid Emulsion.

answer: @entity5


abstract: 1. A study of 24 smelter workers routinely exposed to @entity2 was conducted to evaluate some characteristics of its absorption and excretion. A statistically significant correlation was found between airborne @entity2 concentrations below 300 mug/m3 and urinary @entity1 values below 500 mug/liter. These @entity0 wore personal monitors for five consecutive work days and were determined to have been exposed to average airborne @entity1 concentrations of 53 mug/m3 (70 mug/m3 of @entity2 ) which increased their urinary @entity1 values from 152 mug/liter to 200 mug/liter (an average gain on 32%). 2. The background average urinary @entity1 value for adult males not exposed to @entity2 in industry was determined to be 52.6 mug/liter for 204 @entity0 during preemployment examinations. 3. After removal from industrial @entity2 exposure, the rate of fall in urinary @entity1 values varies with the magnitude of the urinary @entity1 level. An initial decrease of 9.5% per day was measured for workers having urinary @entity1 values below 200 mug/liter. The initial decrease is about 21% per day for workers with urinary @entity1 values over 600 mug/liter. 4. It was determined that @entity1 in seafood can alter, in a dramatic fashion, the urinary @entity1 values determined for smelter workers within 24 hours following consumption. It is recommended, therefore, that the absorption of @entity2 due to industrial exposure is best evaluated from urine samples collected at least two days after seafood has been eaten.

title: XXXX absorption and excretion in industry.

answer: @entity2


abstract: UNASSIGNED: The p @entity13 mutation of the @entity12 proto-oncogene is associated with a low penetrance of @entity4 ( @entity4 ). Thus, there is a lack in guidelines on management of these @entity0 presenting without a @entity7 . CLINICAL CASE: A 27-year-old @entity0 presented with a history of severe @entity3 , @entity11 , diaphoresis and @entity2 . Twenty-four-hour urinary @entity6 and @entity10 levels were exclusively up to 20 times the normal limit. CT-scan and MRI found a 35-mm diameter right @entity1 , highly intense in T2- and hypo-intense in T1-weighted image, enhanced after @entity9 injection. After alpha-adrenergic blocker treatment, a surgical resection of the @entity1 was performed; this latter proved to be a @entity8 . Genetic screening only revealed a germline p @entity13 mutation of the @entity12 proto-oncogene. However, the @entity0 showed no evidence of MEN2: basal calcitonin was normal and @entity5 infusion test was negative. Thyroid ultrasound revealed a TIRADS 3 nodule with benign cytology. Total thyroidectomy was suggested but withheld due to the @entity0 's refusal and a close follow-up was decided. CONCLUSION: This rare case of p @entity13 mutation-related @entity8 without evidence of @entity4 questions the indication for prophylactic thyroidectomy in mutation carriers, as recent data challenges its pathogenicity.

title: Questioning the pathogenic role of the p @entity13 mutation of the XXXX proto-oncogene: Insight from a case report.

answer: @entity12


abstract: UNASSIGNED: The p @entity13 mutation of the @entity12 proto-oncogene is associated with a low penetrance of @entity4 ( @entity4 ). Thus, there is a lack in guidelines on management of these @entity0 presenting without a @entity7 . CLINICAL CASE: A 27-year-old @entity0 presented with a history of severe @entity3 , @entity11 , diaphoresis and @entity2 . Twenty-four-hour urinary @entity6 and @entity10 levels were exclusively up to 20 times the normal limit. CT-scan and MRI found a 35-mm diameter right @entity1 , highly intense in T2- and hypo-intense in T1-weighted image, enhanced after @entity9 injection. After alpha-adrenergic blocker treatment, a surgical resection of the @entity1 was performed; this latter proved to be a @entity8 . Genetic screening only revealed a germline p @entity13 mutation of the @entity12 proto-oncogene. However, the @entity0 showed no evidence of MEN2: basal calcitonin was normal and @entity5 infusion test was negative. Thyroid ultrasound revealed a TIRADS 3 nodule with benign cytology. Total thyroidectomy was suggested but withheld due to the @entity0 's refusal and a close follow-up was decided. CONCLUSION: This rare case of p @entity13 mutation-related @entity8 without evidence of @entity4 questions the indication for prophylactic thyroidectomy in mutation carriers, as recent data challenges its pathogenicity.

title: Questioning the pathogenic role of the p XXXX mutation of the @entity12 proto-oncogene: Insight from a case report.

answer: @entity13


abstract: OBJECTIVE: To develop a consensus on a set of key clinical outcomes for the evaluation of preventive interventions for @entity3 in asymptomatic pregnant @entity0 . METHODS: A two-stage web-based Delphi survey and a face-to-face meeting of key stakeholders were used to develop a consensus on a set of critical and important outcomes. We approached five stakeholder groups (parents, midwives, obstetricians, neonatologists, and researchers) from middle- and high-income countries. Outcomes subjected to the Delphi survey were identified by systematic literature review and stakeholder input. Survey @entity0 scored each outcome on a 9-point Likert scale anchored between 1 (limited importance) and 9 (critical importance). They had the opportunity to reflect on total and stakeholder subgroup feedback between survey stages. For consensus, defined a priori, outcomes required at least 70% of @entity0 of each stakeholder group to score them as "critical" and less than 15% as "limited." RESULTS: A total of 228 @entity0 from five stakeholder groups from three lower middle-income countries, seven upper middle-income countries, and 17 high-income countries were asked to score 31 outcomes. Of these @entity0 , 195 completed the first survey and 174 the second. Consensus was reached on 13 core outcomes: four were related to pregnant @entity0 : maternal mortality, maternal @entity2 or @entity1 , prelabor rupture of membranes, and harm to mother from intervention. Nine were related to offspring: gestational age at birth, offspring mortality, birth weight, early neurodevelopmental morbidity, late neurodevelopmental morbidity, gastrointestinal morbidity, @entity2 , @entity4 , and harm to offspring from intervention. CONCLUSION: This core outcome set for studies that evaluate prevention of @entity3 developed with an international multidisciplinary perspective will ensure that data from trials that assess prevention of @entity3 can be compared and combined. DATABASE REGISTRATION: COMET Initiative, http://www.comet-initiative.org/studies/details/603, Registration Number: 603.

title: A Core Outcome Set for Evaluation of Interventions to Prevent XXXX .

answer: @entity3


abstract: A 62-year-old @entity0 was admitted due to @entity5 and @entity9 . Magnetic resonance(MR)images demonstrated watershed @entity3 in the territory of the left middle cerebral artery, occlusion of the left internal carotid artery, and severe @entity2 of the right internal carotid artery at the neck. He was treated with a recombinant tissue plasminogen activator. One month later, angiography revealed @entity8 with residual severe @entity2 at the neck. We attempted carotid artery stenting( @entity6 )on the left internal carotid artery, but could not pass the guide wire through the @entity2 . Therefore, we performed @entity6 on the right carotid artery instead. At the second day after @entity6 , the @entity0 showed @entity5 , @entity4 , and @entity9 . MR images showed a new @entity3 in the left cerebral hemisphere and bilateral multifocal segmental arterial constrictions. By keeping his blood pressure at a high enough level for one week, his symptoms were relieved, and MR images showed resolution of the vessel constrictions. From this case, we can conclude that this kind of @entity7 after @entity6 require contrasting treatments to those for @entity1 . Interventionalists should be aware of this condition and its treatments.

title: [Possible Cerebral Infarction due to XXXX after Carotid Artery Stenting:A Case Report].

answer: @entity7


abstract: UNASSIGNED: The epithelioid variant of malignant @entity5 (eMPNST) is an extremely rare soft tissue @entity0 comprising less than 5% of all MPNSTs. It is distinguished cytomorphologically from a conventional MPNST by the presence of polymorphous round epithelioid cells arranged in loose clusters with or without spindled @entity0 cells. These features pose a diagnostic challenge because the differential diagnosis involves a variety of mesenchymal and @entity4 including @entity2 , @entity6 epithelioid @entity7 , @entity9 , @entity8 , @entity1 , and @entity3 . Thus, it may become imperative to perform immunochemical stains on cell blocks of FNA aspirates to arrive at definitive diagnosis. Reports describing the cytologic features of eMPNST are rare. Herein, we report a case of eMPNST with focus on cytomorphologic and cytoimmunochemical features and differential diagnosis. Diagn. Cytopathol. 2015.    2015 Wiley Periodicals, Inc.

title: Fine-needle aspiration cytology of epithelioid malignant XXXX : A case report and review of the literature.

answer: @entity5


abstract: BACKGROUND: @entity2 ( @entity3 ) is an aggressive variant of conventional @entity3 (CCa) with mixed @entity3 comprising up to 5% of all @entity2 . @entity3 may be underestimated on T2-weighted (T2W) MRI. This study assessed the mp-MRI appearance of @entity3 as compared with CCa. METHODS: With research ethics board approval, we identified 38 @entity0 who underwent mp-MRI (T2W, DWI, and DCE) and radical prostatectomy (RP) between 2012 and 2014. Eight @entity3 in 8 @entity0 and 39 CCa @entity1 foci in 30 consecutive @entity0 were identified. @entity1 volume, apparent diffusion coefficient (ADC;10(-3) mm(2) /s), and time-signal intensity (SI) curves were calculated. Parametric data were compared using the Kruskal-Wallis test and univariate regression. Time-SI curves were compared using the chi-square test. RESULTS: @entity1 volumes were: 1.62(  1.02) for @entity3 , 1.03(  0.54) for Gleason 9, 0.88(  0.93) for Gleason 7/8, and 0.26(  0.14) mL for Gleason 6. There was no difference in size between @entity3 and Gleason 9 (P   =   0.22); however, @entity3 were larger than Gleason 7/8 (P   =   0.03) and Gleason 6 (P   =   0.003) @entity1 . ADC values were: 0.789(  0.22) for @entity3 , 1.01(  0.19) for Gleason 9, 0.992(  0.23) for Gleason 7/8 and 1.389(  0.41) 10(-3) mm(2) /s for Gleason 6 @entity1 . There was no difference in ADC between @entity3 and Gleason 9 (P   =   0.14) or Gleason 7/8 (P   =   0.055) @entity1 . There was a difference in ADC for @entity3 and Gleason >= 7 CCa compared to Gleason 6 @entity1 , (P   <   0.001 and P   =   0.012). All @entity3 demonstrated type III time-SI curves. Gleason   >=    7 @entity1 demonstrated @entity4 . Gleason 6 @entity1 demonstrated Type I/II time-SI curves. There was no difference in curve type between groups, (P   =   0.18). CONCLUSION: Although @entity3 mimics Gleason score 3   +   3   =   6 @entity1 at T2W MRI; @entity3 resembles Gleason >= 7 CCa on mp-MRI.

title: Multi-parametric (mp) MRI of XXXX .

answer: @entity2


abstract: The @entity1 Control Program began its reorganization in 1979, when the Honduran Ministry of Public Health designated @entity1 as one of its priority problems. Administrative and logisitical problems faced by the program were exacerbated by the public's negative image of the disease and the consequent rejection of anything related to it, including medical diagnosis and treatment. A baseline investigation was carried out to determine the knowledge, attitudes and behaviors of the public, @entity0 and @entity0 ' relatives regarding @entity1 ( @entity1 ). Sampled were 361 healthy adults, 75 @entity1 @entity0 , 55 relatives of @entity0 , 20 health personnel, 12 nurses in 12 health centers, and 3 epidemiologists. Data was gathered using surveys (healthy population), focus groups (healthy population, @entity0 ) unstructured interviews (relatives, health personnel, nurses and epidemiologists) and focused interviews (relatives). The investigation confirmed the existence of social rejection toward @entity1 . The disease is considered quite contagious, and is associated with extreme poverty, filth and @entity2 . The @entity0 stated that this rejection is 1 of the greatest burdens of their disease; they considered themselves a danger to others and expressed feelings of guilt. The most recognized symptom was coughing and expectoration. A @entity0 with a persistent cough does not however, want to think of @entity1 , except as a very remote possibility. Health personnel also fail to perceive a persistent cough as a respiratory symptom and possible indicator of @entity1 . Cough syrups and bronchial decongestants are the most widely distributed medicines in rural health centers. Both the @entity0 and the general population queried knew that @entity1 is curable, although they doubted that the @entity0 could recover his/her full health. @entity0 ' fear was that the long period of treatment would inevitably lead to their neighbors discovering that they had the disease and rejecting them. The health system's capacity to diagnose and treat @entity1 was also analyzed. Several problems were detected in the diagnosis of respiratory cases, e.g., difficulties leading to long delays in the collection and analysis of sputum samples and in the subsequent reporting of the findings. Moreover, instructions given to the @entity0 are quite vague as to exactly what quality sputum is needed and how best to obtain it. These problems affect the number of @entity0 who are diagnosed and treated, but seem to have little bearing on those already being treated. An education campaign was prepared based on these findings. Its goals were toinform the population at large that @entity1 @entity0 no longer transmit the disease, that they can be completely cured if treatment is begun promptly, and that a persistent cough lasting for more than 15 days may be a symptom. A pamphlet has been developed to better educate the @entity0 and their relatives. It is concluded that an understanding of and familiarity with the client's perspective can help educational programmers identify exactly which facts or opinions must be reinforced or modified so that beneficial health services are utilized.

title: Integrating the client's perspective in planning a XXXX education and treatment program in Honduras.

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity3 ) is a @entity1 condition that can have a substantial negative impact on @entity0 ' lives. However, UK-specific data on the debilitating impact of @entity3 , in terms of @entity0 ' experience of @entity1 and impairments in Health-Related Quality of Life (HRQoL) are limited. The Zoster Quality of Life (ZQOL) study, a large-scale UK cross-sectional study, was conducted to quantify the burden of @entity3 in UK @entity0 . METHODS: A total of 229 @entity3 @entity0 aged 50 years or over were recruited from primary and secondary/tertiary care centres throughout the UK. @entity0 completed a battery of validated questionnaires, including the @entity1 Inventory (ZBPI), the Medical Outcomes Study Short-Form 36 (SF-36) and the EuroQol-5 Dimensions (EQ-5D) on initial presentation to the doctor and again 7-14 days later. At follow-up @entity0 also completed the Treatment Satisfaction with Medication (TSQM) questionnaire. Where available, mean questionnaire scores in the @entity3 population were compared to scores for age-matched norms to investigate the burden associated with @entity3 . RESULTS: @entity1 was prominent among @entity0 , with 57.9% at the initial study visit reporting @entity1 in the preceding 24 hours at levels typically considered to have a significant impact on HRQoL (i.e. ZBPI worst @entity1 >=  5). This was reflected in SF-36 and EQ-5D scores that were significantly lower for @entity0 when compared to age-matched norms (p < 0.05) - except for the SF-36 domain of physical functioning. HRQoL was inversely associated with levels of reported @entity1 , with those @entity0 in the greatest amount of @entity1 reporting the greatest HRQoL impact. However, there was no association between @entity1 severity and @entity0 age. The majority of @entity0 (69.4%) received antivirals within 72 hours of @entity2 appearing and 69.9% of @entity0 were also taking analgesics for the management of @entity1 . TSQM scores indicated that @entity0 were least satisfied with the effectiveness of their prescribed treatment. CONCLUSIONS: The acute presentation of @entity3 is a @entity1 experience that can have a significant impact on the physical and mental wellbeing of sufferers. Findings highlight significant unmet need among @entity0 , particularly in terms of the effectiveness of therapies for the management of @entity3 .

title: XXXX in the UK: findings from the zoster quality of life (ZQOL) study.

answer: @entity3


abstract: A 78-year-old @entity0 presented to hospital with new onset @entity4 and fever. The working diagnosis was of @entity5 due to an infection of unknown source, and empirical i.v. antibiotic treatment was given. Two days later, he deteriorated and developed clinical features in keeping with a total anterior circulation @entity1 . Brain imaging was unremarkable. Blood cultures grew an organism subsequently identified as Facklamia languida. Following treatment with broad-spectrum antibiotics, his condition improved. A diagnosis of @entity2 , leading to presumed (unwitnessed) @entity3 and Todd's paresis was made. The @entity0 went on to make a full recovery and was discharged home. @entity1 mimics are common and may be eminently treatable. Around a quarter of @entity0 initially suspected to have a @entity1 are subsequently found to have an alternative diagnosis.

title: A very unusual organism causing XXXX -like symptoms.

answer: @entity1


abstract: BACKGROUND: @entity2 represent a formidable surgical challenge. Several comprehensive @entity2 centers, including ours, with advanced expertise have recently emerged across the country. However, the effects of tertiary specialization remain largely unclear. We aimed to evaluate the impact of developing a comprehensive @entity2 center on the referral patterns and costs of @entity0 with @entity2 . METHODS: A prospectively maintained database was used to identify all @entity0 undergoing open @entity3 repair (VHR) between 2006 and 2013 at the Case @entity2 . @entity0 were separated into two groups by @entity4 code: those traveling either <25 or >100 miles. Demographics, operative characteristics, length of stay and costs data were analyzed. RESULTS: Of all @entity0 who underwent open VHR during the study period, 287 met the inclusion criteria. @entity2 , width and area were all significantly larger for @entity0 traveling >100 miles (P  <  0.01 for all). These @entity0 were also more likely to have active mesh infections (OR 3.57) and non-healing wounds (OR 5.00) when compared with local @entity0 . Length of hospital stay was significantly longer for @entity0 traveling >100 miles compared to those traveling <25 miles (9.7 vs. 6.8; P  <  0.0001). Surgical site occurrence, @entity1 and @entity2 recurrence rates were similar between the two groups during the follow-up period. @entity0 who traveled >100 miles incurred significantly higher fixed direct and variable direct costs compared to those who traveled <25 miles (P  <  0.05 for both). CONCLUSION: The development of a comprehensive @entity2 center results in centralization of complex @entity2 care. @entity0 traveling >100 miles for @entity3 repair have significantly larger and more @entity2 . The implications for improved @entity0 outcomes and potential reimbursement issues for providing this care should be carefully evaluated.

title: The impact of developing a comprehensive @entity2 center on the referral patterns and complexity of XXXX care.

answer: @entity2


abstract: BACKGROUND: @entity2 represent a formidable surgical challenge. Several comprehensive @entity2 centers, including ours, with advanced expertise have recently emerged across the country. However, the effects of tertiary specialization remain largely unclear. We aimed to evaluate the impact of developing a comprehensive @entity2 center on the referral patterns and costs of @entity0 with @entity2 . METHODS: A prospectively maintained database was used to identify all @entity0 undergoing open @entity3 repair (VHR) between 2006 and 2013 at the Case @entity2 . @entity0 were separated into two groups by @entity4 code: those traveling either <25 or >100 miles. Demographics, operative characteristics, length of stay and costs data were analyzed. RESULTS: Of all @entity0 who underwent open VHR during the study period, 287 met the inclusion criteria. @entity2 , width and area were all significantly larger for @entity0 traveling >100 miles (P  <  0.01 for all). These @entity0 were also more likely to have active mesh infections (OR 3.57) and non-healing wounds (OR 5.00) when compared with local @entity0 . Length of hospital stay was significantly longer for @entity0 traveling >100 miles compared to those traveling <25 miles (9.7 vs. 6.8; P  <  0.0001). Surgical site occurrence, @entity1 and @entity2 recurrence rates were similar between the two groups during the follow-up period. @entity0 who traveled >100 miles incurred significantly higher fixed direct and variable direct costs compared to those who traveled <25 miles (P  <  0.05 for both). CONCLUSION: The development of a comprehensive @entity2 center results in centralization of complex @entity2 care. @entity0 traveling >100 miles for @entity3 repair have significantly larger and more @entity2 . The implications for improved @entity0 outcomes and potential reimbursement issues for providing this care should be carefully evaluated.

title: The impact of developing a comprehensive XXXX center on the referral patterns and complexity of @entity2 care.

answer: @entity2