abstract: AIM: Endothelial dysfunction was observed in @entity0 with @entity5 . The aim of the present study was to evaluate the extent of endothelial function impairment in @entity0 with @entity5 . METHODS: We systematically searched through the PubMed, Embase, China National Knowledge Infrastructure and Wanfang databases for studies dated up to January 2015. All observational studies that compared endothelial function between @entity5 @entity0 and healthy controls were included. Endothelial function was measured by brachial artery flow-mediated @entity1 and @entity4 -induced dilatation techniques. RESULTS: Eleven observational studies were identified. Meta-analysis indicated that @entity5 @entity0 were associated with a reduction in brachial artery flow-mediated @entity1 (weighted mean difference, -4.82%; 95% confidence interval [CI], -5.63 to -4.00) compared with the healthy controls. Subgroup analysis indicated that the @entity0 with @entity6 or a body mass index of more than 30   kg/m(2) appeared to have a greater reduction in their flow-mediated @entity1 . However, no significant differences were observed in the @entity4 -induced @entity1 (weighted mean difference, -0.4%; 95% confidence interval, -2.19 to 1.39). CONCLUSION: @entity5 is associated with a greater risk of @entity2 as indicated by the decreased brachial artery flow-mediated @entity1 . Assessment of endothelial function may be recommended to identify subclinical @entity3 and to create subgroups of @entity5 @entity0 who are at higher risk of future cardiovascular events.

title: Association of @entity5 with impaired endothelial function by flow-mediated XXXX : A meta-analysis.

answer: @entity1


abstract: Development of early embryonic stages before activation of the embryonic genome depends on sufficiently stored products of the maternal genome and adequate activation, deactivation, and relocation of proteins. To establish protein function, several posttranslational events (e.g. proteolytic activation, phosphorylation, or secretion) are frequently essential and thereby prevent prediction of protein abundance from transcript abundance. Consequently, proteomic studies are indispensable to characterise the molecular processes governing early embryonic development and to establish corresponding regulatory networks. Here, we present a quantitative proteome analysis of @entity1 zygotes and embryos at the 2-cell and 4-cell stage. Cumulus-oocyte complexes (COC) were prepared from @entity1 ovaries obtained from a local abattoir and selected for a compact layer of cumulus cells. In vitro maturation, fertilization, and embryo production were performed according to standard procedures. For quantitative isobaric tags for relative and absolute quantitation (iTRAQ)-liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, protein from batches of 50 MII oocytes (serving as a reference), zygotes, 2-cell and 4-cell stage embryos, respectively, was extracted. Quantitative proteome analysis of iTRAQ-labelled tryptic peptides was performed on an Orbitrap XL instrument (Thermo Fisher, Waltham, MA, USA) coupled to an Eksigent nano-liquid chromatography system (AB Sciex, Framingham, MA, USA). The tandem MS data were analysed by MASCOT and filtered for a false discovery rate (FDR) of <1%. Quantification of iTRAQ signals was accomplished with the Q+ module of the Scaffold software (Proteome Software Inc., Portland, OR, USA). t-Tests, ANOVA and principal component analysis (PCA) analysis were performed using R (R Core Development Team, Vienna, Austria). From 4 biological replicates, 1072 proteins were identified and quantified. Eighty-seven differed significantly in abundance between the 4 stages (log2 fold change>=  0.6 , P <=0.05). The proteomes of 2-cell and 4-cell embryos differed most from the reference MII oocyte, and a considerable fraction of proteins continuously increases in abundance during the stages analysed. Bioinformatic analysis of abundance altered proteins provided evidence that the proteins @entity2 and @entity3 involved in the p53 pathway play a major role during early development, as well as proteins of the lipid metabolism, in particular @entity4 . Furthermore, a group of proteins (e.g. @entity5 , @entity6 , @entity7 , @entity8 , and @entity9 ) is engaged in mitosis. In addition, we detected relevant differences between transcript and protein abundance levels; for example, for @entity9 . In conclusion, this study identified and quantified numerous proteins important for early embryogenesis so far not described in the @entity0 system, and contributed protein profiles for key players previously described. Our results highlight the importance of innovative proteomic tools and workflows to complement transcriptome data of early embryogenesis.

title: 83 stage-specific proteome signatures in early XXXX embryo development.

answer: @entity1


abstract: Over the last three decades there has been a world-wide decline in the incidence and severity of @entity5 and @entity7 , but the death rate in Singapore from chronic @entity7 has risen from 3.6 per 100,000 population in 1966 to 4.4 per 100,000 in 1977. @entity2 from @entity7 are very common, and between 1967 to 1979, 715 surgical procedures were performed for @entity2 , and of these, 654 procedures involved the mitral valve which was most commonly affected by the disease process. Since many of the @entity0 were female and in the @entity0 -bearing age, conservative procedures on the mitral valve were performed whenever possible. Mitral valvotomy for @entity6 relieved symptoms effectively; and for restenosis of the mitral valve, more than half of the @entity0 underwent a second valvotomy with functional improvement. Mitral valve replacement was reserved for the severely distorted valve, sometimes calcified, and where there was stenosis associated with @entity1 . Between 1971 to 1979, 162 mitral valves were replaced and actuarial studies showed 80% survival five years after surgery. 30 aortic and mitral valve replacements were performed in this same period with an operative mortality of 16.7%. Only 75 aortic valves were replaced for @entity2 and 14 of these also had associated mitral and triscuspid valve disease. The prosthetic valves commonly used for replacement were the Starr-Edwards non-cloth covered valves, models 6120 and 1260. All @entity0 that had valve replacements were treated with long-term anticoagulation with @entity4 . The incidence of @entity3 was low, being 8% for mitral valve replacement and the majority of these episodes occurred in the first three months after surgery.

title: Surgical management of XXXX in Singapore.

answer: @entity7


abstract: It is known that in vitro @entity0 embryo development is negatively affected by the increased oxidative stress occurring under culture conditions. The oxidative damage of cell components via reactive @entity1 species interferes with proper cell function. Buffalo embryos are particularly sensitive to oxidative stress because of their high lipid content (Boni et al. 1992 Acta Med. Vet. 38, 153-161). @entity9 (LE) is a powerful scavenger of @entity8 radicals ( @entity7 ) and an inhibitor of @entity2 or @entity6 ion-dependent generation of @entity7 from @entity3 ( @entity4 ). The aim of this study was to evaluate whether enriching the in vitro-culture medium with LE improves in vitro embryo production efficiency in buffalo. Abattoir-derived buffalo oocytes (n=854, over 6 replicates) were in vitro matured and fertilized according to standard procedures (Gasparrini et al. 2006 Theriogenology 65, 275-287). Twenty hours after IVF presumptive zygotes were cultured in SOFaa supplemented by 8mgmL(-1) BSA in a controlled gas atmosphere consisting of 5% @entity5 , 7% O2, 88% N2, in humidified air, at 38.5  C with 0 (control; n=214), 0.05mM LE (n=217), 0.1mM LE (n=204), and 1mM LE (n=219). Cleavage rate was assessed at the time of change of culture (Day 5) and the cleaved elements were cultured for a further 2 days. The embryos obtained by the end of culture, i.e. on Day 7 post-IVF, were scored for quality, based on morphological criteria, and for developmental stage, as previously described (Robertson, Nelson 2010 Manual of the International Embryo Transfer Society 86-105). The percentages of total transferable embryos and Grade 1 and 2 blastocysts in relation to cleaved oocytes were recorded. Because the chronology of development is known to be one of the most reliable parameters for assessing quality, the percentage of fast-developing embryos, i.e. hatched and expanded blastocysts, was also recorded. Data were analysed by Chi-squared test. Cleavage rate was not affected by the treatment (71.4, 66.8, 68.7, and 63.0%, respectively, with 0, 0.05, 0.1, and 1mM LE). The total embryo output increased in groups supplemented with 0.05 and 0.1mM LE (31.3, 42.2, 43.8, and 21.7%, respectively, with 0, 0.05, 0.1, and 1mM LE; P<0.05). However, the enrichment of in vitro culture with 0.1mM LE also increased the percentage of Grade 1 and 2 blastocysts compared with the control and to 1mM LE (21.6, 30.9, 33.9, and 21.7%, respectively, with 0, 0.05, 0.1, and 1mM LE; P<0.05). Likewise, 0.1mM LE gave higher percentages of fast developing embryos than the control and 1mM LE groups. In conclusion, these results demonstrated a beneficial effect of LE during culture on buffalo in vitro embryo development. The dose response trial indicated that the optimal concentration is 0.1mM that also influenced the chronology of development and hence embryo viability.

title: 135 effect of XXXX supplementation during culture on in vitro embryo development in buffalo (bubalus bubalis).

answer: @entity9


abstract: OBJECTIVE: To evaluate the efficacy of radiofrequency ablation (RFA) in the treatment of loco-regional, recurrent, and well-differentiated @entity2 . MATERIALS AND METHODS: Thirty-five recurrent well-differentiated @entity2 (RTC) in 32 @entity0 were treated with RFA, between March 2008 and October 2011. RTCs were detected by regular follow-up ultrasound and confirmed by biopsy. All @entity0 had fewer than 3 RTCs in the neck and were at high surgical risk or refused to undergo repeated surgery. Average number of RFA sessions were 1.3 (range 1-3). Post-RFA biopsy and ultrasound were performed. The mean follow-up period was 30 months. Pre- and post-RFA serum thyroglobulin values were evaluated. RESULTS: Thirty-one @entity0 with 33 RTCs were treated with RFA only, whereas 1 @entity0 with 2 RTCs was treated with RFA followed by surgery. At the last follow-up ultrasound, 31 (94%) of the 33 RTCs treated with RFA alone completely disappeared and the remaining 2 (6%) RTCs showed decreased volume. The largest diameter and volume of the 33 RTCs were markedly decreased by 93.2% (from 8.1    3.4 mm to 0.6    1.8 mm, p < 0.001) and 96.4% (from 173.9    198.7 mm(3) to 6.2    27.9 mm(3), p < 0.001), respectively. Twenty of the 21 RTCs evaluated with post-RFA biopsies (95%) were negative for @entity1 . One (5%) showed remaining @entity1 that was removed surgically. The serum thyroglobulin was decreased in 19 of 26 @entity0 (73%). Voice change developed immediately after RFA in 6 @entity0 (19%) and was spontaneously recovered in 5 @entity0 (83%). CONCLUSION: Radiofrequency ablation can be effective in treating loco-regional, recurrent, and well-differentiated @entity2 in @entity0 at high surgical risk.

title: Radiofrequency ablation to treat loco-regional recurrence of well-differentiated XXXX .

answer: @entity2


abstract: Two cases of @entity4 occurred in a hospital within a two-week period. Both @entity0 were infected with the same organism, @entity5 , type 1a, bacteriophage type 6 (lysotype 1652). Both @entity0 were born in the same delivery room, 17 hours apart. The index @entity0 became septic shortly after birth and died after 48 hours despite antibiotic therapy. The mother of the index @entity0 was febrile and had @entity6 . The second @entity0 became ill with @entity3 at 13 days of age. Neither @entity0 nor mothers were attended by the same medical or nursing staff nor were they in the same labor or postpartum areas or nurseries. However, both @entity0 were resuscitated in the same delivery room after birth by means of laryngoscope, suction catheter, and emergency resuscitation (Ambu) bag. Although it was hospital policy to clean and sterilize resuscitation equipment after use, the equipment had only been wiped with @entity1 between @entity0 in this instance, since sterile replacement equipment was not available during the early-morning hours when the index birth occurred. Therefore, we believe the contaminated resuscitation equipment was the source of infection in the second @entity0 . This episode emphasizes the importance of appropriate disinfection of respiratory resuscitation equipment to prevent @entity2 due to @entity5 , an unusual but important pathogen in neonates.

title: XXXX in a delivery room.

answer: @entity4


abstract: UNASSIGNED: Sj  @entity4 ( @entity4 ), an @entity5 , is associated with dysfunction of the secretory salivary gland epithelium, leading to @entity7 . The etiology of @entity3 progression is poorly understood as it is typically not diagnosed until late stage. Since @entity2 models allow the study of disease progression, we investigated the NOD/ShiLtJ @entity2 to explore temporal changes to the salivary epithelium. In the NOD/ShiLtJ model, @entity4 presents secondary to autoimmune @entity1 , and @entity3 is reportedly fully established by 20 weeks. We compared epithelial morphology in the submandibular salivary glands (SMG) of NOD/ShiLtJ @entity2 with SMGs from the parental strain at 12, 18, and 22 weeks of age and used immunofluorescence to detect epithelial proteins, including the acinar marker, @entity11 , ductal cell marker, @entity9 , myoepithelial cell marker, smooth muscle a-actin, and the basal cell marker, @entity10 , while confirming immune infiltrates with @entity8 . We also compared these proteins in the labial salivary glands of @entity0 @entity4 @entity0 with control tissues. In the NOD/ShiLtJ SMG, regions of lymphocytic infiltrates were not associated with widespread epithelial tissue degradation; however, there was a decrease in the area of the gland occupied by secretory epithelial cells in favor of ductal epithelial cells. We observed an expansion of cells expressing @entity10 within the ducts and within the smooth muscle a-actin(+) basal myoepithelial population. The altered acinar/ductal ratio within the NOD/ShiLtJ SMG likely contributes to @entity6 , while the expansion of @entity10 positive-basal cells may reflect loss of function or indicate a regenerative response. Anat Rec, 2015.    2015 Wiley Periodicals, Inc.

title: Changes in the Submandibular Salivary Gland Epithelial Cell Subpopulations During Progression of Sj  gren's Syndrome-Like Disease in the NOD/ShiLtJ XXXX Model.

answer: @entity2


abstract: OBJECTIVE: The burden and psychological impact of providing care to a loved one with @entity1 is significant and associated with a number of problems including @entity3 and @entity4 . While engaging in healthy behaviors such as proper nutrition, exercise, and stress reduction may improve sleep and @entity4 , few studies have focused on this relationship. The objective of this study is to examine the relationship of health behaviors with @entity3 and @entity4 in transplant caregivers. METHODS: Data were analyzed from a cross-sectional survey of 78 caregivers of @entity0 undergoing allogeneic hematopoietic stem cell transplantation. Measures included: Health-Promoting Lifestyle Profile II (HPLP-II), Brief Symptom Inventory (Distress), Caregiver Reaction Assessment (Caregiver Burden), Pittsburgh Sleep Quality Index, and the Multidimensional Fatigue Symptom Inventory Short-Form. RESULTS: Controlling for age, gender, BMI, burden and distress, health behaviors predicted @entity3 (B   =   -0.408, p   =   0.021) and @entity4 (B   =   -0.966, p   <   0.001). Stress management (B   =   -0.450, p   =   0.001), nutrition (B   =   -0.249, p   =   0.048), and interpersonal relationships (B   =   -0.319, p   =   0.049) were the HPLP-II subscales that significantly predicted @entity3 ; nearly every HPLP-II subscale predicted @entity4 . CONCLUSIONS: Despite the burden and distress associated with caregiving, engaging in healthy behaviors may help to improve @entity2 . Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

title: The relationship of health behaviors with XXXX .

answer: @entity2


abstract: BACKGROUND: In late 2012, a national pill crisis led French @entity0 to promptly change their behavior regarding contraception, with a significant increase in the use of first-generation and second-generation combined oral contraceptives to the detriment of third-generation and fourth-generation products (C3Gs and C4Gs). OBJECTIVE: To assess the impact of the sharp changes in 2013 on the rate of @entity0 hospitalized for @entity1 in France. METHODS: All hospitalized @entity1 in @entity0 aged 15-49  years, excluding those occurring during delivery stay, were identified from the French national hospital discharge databases from 2010 to 2013. Hospitalization rates, overall and by age group, were calculated. We compared rates in 2013 with those in 2012, and with mean rates over the preceding 3-year period (2010-2012). Two populations of non-users of contraceptives were used as control groups: @entity0 aged 15-49  years, and @entity0 aged 50-69  years. The expected @entity1 incidence, estimated by modeling the number of expected cases based on modifications of combined oral contraceptive exposure, was also considered. RESULTS: In France, in 2013 as compared with 2012, the @entity1 hospitalization incidence rate in @entity0 aged 15-49  years fell by 10.6%, corresponding to a reduction of 322 hospitalizations (95% confidence interval -468 to -156). The expected @entity1 reduction is consistent with the observed reduction in hospitalization incidence rate (-10.2% and -10.6%, respectively). Such a pattern was not observed in the control groups. CONCLUSIONS: The sharp change in contraception methods, with decreased use of C3Gs and C4Gs, probably played a major role in the reduction in @entity2 morbidity in France.

title: Impact of the sharp changes in the use of contraception in 2013 on the risk of XXXX in France.

answer: @entity1


abstract: AIM: To investigate whether @entity0 with @entity2 ( @entity2 ) can be distinguished based on the positivity of anti-centromere antibody (ACA), and if so, whether the subgroups differ in their clinical and laboratory features. METHODS: Eleven @entity0 with ACA-positive and 71 @entity0 ACA-negative @entity2 were examined. All @entity0 had minor salivary gland biopsy; sociodemographic data, glandular and extraglandular manifestations, and laboratory findings, including autoantibodies, complement and immunoglobulin levels, were analyzed. European League Against @entity3 activity index (ESSDAI) and @entity1 damage index (SSDDI) were also measured. RESULTS: The prevalence of ACA among @entity2 @entity0 was 13.4%. ACA-positive @entity2 @entity0 had a higher prevalence of @entity6 , @entity8 and @entity5 and a lower prevalence of anti-SSA/Ro and anti- @entity7 /La antibodies compared to ACA-negative @entity0 . Disease activity was higher in ACA-positive @entity0 than in ACA-negative @entity0 , but the damage index did not differ between the two groups. None of the @entity0 who originally had ACA evolved to having full-blown @entity4 . CONCLUSION: @entity0 with @entity2 who have ACA differ from classic @entity2 @entity0 in several clinical and laboratory parameters. ACA should be considered one of the pathogenically relevant autoantibodies for @entity2 .

title: Anti-centromere antibody-positive XXXX : A distinct clinical subgroup?

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to assess the relationship between abnormally increased P-wave terminal force in lead V1 , an electrocardiographic (ECG) marker of @entity6 , and incident @entity2 subtypes. We hypothesized that associations would be stronger with nonlacunar @entity1 , given that we expected @entity6 to reflect the risk of @entity5 rather than in situ @entity7 . METHODS: Our cohort comprised 14,542 @entity0 45 to 64 years of age prospectively enrolled in the @entity3 Risk in Communities study and free of clinically apparent @entity4 ( @entity4 ) at baseline. @entity6 was defined as PTFV1 >4,000 V*ms. Outcomes were adjudicated @entity2 , nonlacunar (including cardioembolic) @entity2 , and @entity1 . RESULTS: During a median follow-up period of 22 years (interquartile range, 19-23 years), 904 @entity0 (6.2%) experienced a definite or probable @entity2 . A higher incidence of @entity1 occurred in those with baseline @entity6 (incidence rate per 1,000 @entity0 -years, 6.3; 95% confidence interval [CI]: 5.4-7.4) than in those without (incidence rate per 1,000 @entity0 -years, 2.9; 95% CI: 2.7-3.1; p < 0.001). In Cox regression models adjusted for potential confounders and incident @entity4 , @entity6 was associated with incident @entity2 (hazard ratio [HR]: 1.33; 95% CI: 1.11-1.59). This association was limited to nonlacunar @entity1 (HR, 1.49; 95% CI: 1.07-2.07) as opposed to @entity1 (HR, 0.89; 95% CI: 0.57-1.40). INTERPRETATION: We found an association between ECG-defined @entity6 and subsequent nonlacunar @entity2 . Our findings suggest that an underlying @entity4 may cause @entity5 in the absence of recognized @entity4 . Ann Neurol 2015;78:Ann Neurol 2015;78:679-696.

title: Electrocardiographic @entity6 and XXXX subtype in the @entity3 risk in communities study.

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to assess the relationship between abnormally increased P-wave terminal force in lead V1 , an electrocardiographic (ECG) marker of @entity6 , and incident @entity2 subtypes. We hypothesized that associations would be stronger with nonlacunar @entity1 , given that we expected @entity6 to reflect the risk of @entity5 rather than in situ @entity7 . METHODS: Our cohort comprised 14,542 @entity0 45 to 64 years of age prospectively enrolled in the @entity3 Risk in Communities study and free of clinically apparent @entity4 ( @entity4 ) at baseline. @entity6 was defined as PTFV1 >4,000 V*ms. Outcomes were adjudicated @entity2 , nonlacunar (including cardioembolic) @entity2 , and @entity1 . RESULTS: During a median follow-up period of 22 years (interquartile range, 19-23 years), 904 @entity0 (6.2%) experienced a definite or probable @entity2 . A higher incidence of @entity1 occurred in those with baseline @entity6 (incidence rate per 1,000 @entity0 -years, 6.3; 95% confidence interval [CI]: 5.4-7.4) than in those without (incidence rate per 1,000 @entity0 -years, 2.9; 95% CI: 2.7-3.1; p < 0.001). In Cox regression models adjusted for potential confounders and incident @entity4 , @entity6 was associated with incident @entity2 (hazard ratio [HR]: 1.33; 95% CI: 1.11-1.59). This association was limited to nonlacunar @entity1 (HR, 1.49; 95% CI: 1.07-2.07) as opposed to @entity1 (HR, 0.89; 95% CI: 0.57-1.40). INTERPRETATION: We found an association between ECG-defined @entity6 and subsequent nonlacunar @entity2 . Our findings suggest that an underlying @entity4 may cause @entity5 in the absence of recognized @entity4 . Ann Neurol 2015;78:Ann Neurol 2015;78:679-696.

title: Electrocardiographic XXXX and @entity1 subtype in the @entity3 risk in communities study.

answer: @entity6


abstract: OBJECTIVE: The aim of this study was to assess the relationship between abnormally increased P-wave terminal force in lead V1 , an electrocardiographic (ECG) marker of @entity6 , and incident @entity2 subtypes. We hypothesized that associations would be stronger with nonlacunar @entity1 , given that we expected @entity6 to reflect the risk of @entity5 rather than in situ @entity7 . METHODS: Our cohort comprised 14,542 @entity0 45 to 64 years of age prospectively enrolled in the @entity3 Risk in Communities study and free of clinically apparent @entity4 ( @entity4 ) at baseline. @entity6 was defined as PTFV1 >4,000 V*ms. Outcomes were adjudicated @entity2 , nonlacunar (including cardioembolic) @entity2 , and @entity1 . RESULTS: During a median follow-up period of 22 years (interquartile range, 19-23 years), 904 @entity0 (6.2%) experienced a definite or probable @entity2 . A higher incidence of @entity1 occurred in those with baseline @entity6 (incidence rate per 1,000 @entity0 -years, 6.3; 95% confidence interval [CI]: 5.4-7.4) than in those without (incidence rate per 1,000 @entity0 -years, 2.9; 95% CI: 2.7-3.1; p < 0.001). In Cox regression models adjusted for potential confounders and incident @entity4 , @entity6 was associated with incident @entity2 (hazard ratio [HR]: 1.33; 95% CI: 1.11-1.59). This association was limited to nonlacunar @entity1 (HR, 1.49; 95% CI: 1.07-2.07) as opposed to @entity1 (HR, 0.89; 95% CI: 0.57-1.40). INTERPRETATION: We found an association between ECG-defined @entity6 and subsequent nonlacunar @entity2 . Our findings suggest that an underlying @entity4 may cause @entity5 in the absence of recognized @entity4 . Ann Neurol 2015;78:Ann Neurol 2015;78:679-696.

title: Electrocardiographic @entity6 and @entity1 subtype in the XXXX risk in communities study.

answer: @entity3


abstract: BACKGROUND: A strategy of early transfer for coronary angiography and intervention is superior to a standard approach of delayed coronary angiography after fibrinolysis for @entity4 ( @entity4 ). @entity4 @entity0 with lesions in noninfarct-related arteries have a worse prognosis compared with @entity0 with @entity2 . This study aimed to assess whether the benefits of an early invasive strategy differ in @entity0 with single vessel and multivessel disease. METHODS: The Trial of Routine ANgioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute @entity4 (TRANSFER-AMI) randomized @entity4 @entity0 receiving fibrinolysis to a strategy of early transfer and coronary angiography vs a standard approach. In this post hoc analysis, we stratified 992 @entity0 into 2 groups according to the presence or absence of multivessel disease. We compared the 2 groups in terms of baseline characteristics, in-hospital management, and @entity0 outcomes, and tested for treatment heterogeneity. RESULTS: Multivessel disease was present in 369 (37%) @entity0 . @entity0 with multivessel disease had a greater rate of the primary composite end point of in-hospital @entity3 , recurrence of @entity6 , recurrent @entity1 , shock, or @entity5 at 30 days (18.2% vs 10.8%; P < 0.001). An early invasive strategy was efficacious in both groups for the primary outcome. In multivariable analysis adjusting for Global Registry of Acute Coronary Events (GRACE) risk score, there was no significant treatment heterogeneity (all P interaction > 0.40) for the primary end point, or @entity3 /recurrence of @entity6 at 6 months and 1 year. CONCLUSIONS: Multivessel disease is present in a significant proportion of @entity4 @entity0 treated with fibrinolysis and is associated with worse outcomes. A strategy of early transfer and coronary intervention after fibrinolysis was beneficial regardless of the presence or absence of multivessel disease.

title: Efficacy of an Early Invasive Strategy After Fibrinolysis in ST-Elevation XXXX Relative to the Extent of Coronary Artery Disease.

answer: @entity4


abstract: PURPOSE: Our aim was to evaluate the rate of occurrence of @entity2 , associated findings, and outcome in a series of cases of prenatally diagnosed clubfoot. METHODS: We conducted a retrospective study of all cases of clubfoot diagnosed prenatally in the ultrasound unit of a French tertiary center from January 2004 through December 2011. Clubfoot was scored as complex or isolated depending on the presence or absence of another structural abnormality observed on sonographic examination. RESULTS: Data from 90 fetuses prenatally diagnosed with clubfoot were included in this study. Thirty-four cases were considered complex (38%) and 56 were considered isolated (62%). A @entity2 was identified in 10 of 33 of the fetuses with complex clubfoot and in 1 of 45 of those with @entity3 (p   <   0.001). Clubfoot was associated with a poor outcome in 5 of 52 cases of @entity3 and in 31 of 34 cases associated with other structural defects (p   <   0.001). The @entity0 was bilateral in 62 cases (69%) and unilateral in 28 (31%). No statistically significantly higher rate of poor outcome was identified when the @entity0 occurred bilaterally nor was a significantly higher rate of @entity2 noted in this condition. CONCLUSIONS: @entity1 and adverse pregnancy outcomes occur more commonly in prenatally diagnosed cases of complex clubfoot than in those of @entity3 . Fetal karyotyping is required in cases of complex clubfoot, but the need for that procedure in @entity3 remains controversial.    2015 Wiley Periodicals, Inc. J Clin Ultrasound, 2015.

title: Prenatal diagnosis of clubfoot: XXXX associated with fetal defects and outcome in a tertiary center.

answer: @entity2


abstract: A case is reported of a @entity7 of the posterior cerebral artery in a 21/2 month old @entity0 . The clinical picture of @entity3 included @entity5 , @entity1 and @entity6 . The @entity2 was detected by two dimensional ultrasonography and CT scan. The carotid and vertebral arteriogram showed an @entity2 located on the posterior cerebral artery. Surgery was performed after neurological improvement, 25 days after admission. The operation was conducted under controlled systemic @entity4 using @entity8 . The mean blood pressure was decreased from 70 mmHg to 40 mmHg during 20 min. This technique established good haemostatic conditions during removal of the @entity2 . Postoperative recovery was uneventful with full neurological recovery. The interest of @entity8 as a @entity4 agent is discussed. The difficulties of monitoring haemodynamic variables in @entity0 are stressed.

title: [Anesthesia with controlled XXXX for treatment of intracranial arterial aneurysm in an @entity0 ].

answer: @entity4


abstract: A case is reported of a @entity7 of the posterior cerebral artery in a 21/2 month old @entity0 . The clinical picture of @entity3 included @entity5 , @entity1 and @entity6 . The @entity2 was detected by two dimensional ultrasonography and CT scan. The carotid and vertebral arteriogram showed an @entity2 located on the posterior cerebral artery. Surgery was performed after neurological improvement, 25 days after admission. The operation was conducted under controlled systemic @entity4 using @entity8 . The mean blood pressure was decreased from 70 mmHg to 40 mmHg during 20 min. This technique established good haemostatic conditions during removal of the @entity2 . Postoperative recovery was uneventful with full neurological recovery. The interest of @entity8 as a @entity4 agent is discussed. The difficulties of monitoring haemodynamic variables in @entity0 are stressed.

title: [Anesthesia with controlled @entity4 for treatment of intracranial arterial aneurysm in an XXXX ].

answer: @entity0


abstract: A retrospective study was performed to determine if the emergency intravenous pyelogram (IVP) is being overused in the evaluation of blunt @entity1 . Medical records of 105 blunt @entity1 @entity0 undergoing IVPs for suspected blunt @entity1 were analyzed. Eighty-eight @entity0 (83.8%) had normal IVPs, and 17 @entity0 (16.2%) had abnormal IVPs. Three of the 105 @entity0 (2.9%) required urologic surgical intervention. The medical records of these @entity0 were examined in detail because it was believed that this @entity0 population needed to be identified by emergency IVP. All three @entity0 requiring urologic surgery had gross @entity2 . All three @entity0 had one or more associated injuries. Two of the three @entity0 had @entity3 . The third @entity0 was obtunded. From this study and information from the literature an algorithm has been constructed as a guideline for a prospective study. Following this guideline no @entity0 in the study requiring urologic surgical intervention would have been missed. Of @entity0 requiring an emergency IVP, 7.3% would have required urologic surgery. This would have resulted in a savings of  10,432 at our institution.

title: Should the emergency IVP be used more selectively in blunt XXXX ?

answer: @entity1


abstract: OBJECTIVE: Brown adipose tissue (BAT) can generate heat by burning @entity4 , a process mediated by @entity3 ( @entity3 ). @entity2 ( @entity2 ) depots can gain BAT-like properties, and various studies have suggested that females have more active BAT or BAT-like @entity2 . We studied sex differences in BAT-like properties of @entity0 perirenal adipose tissue. METHODS: Perirenal and subcutaneous adipose tissue was obtained from 20 male and 24 female healthy live kidney donors. Mesenchymal stem cells (MSCs), adipocyte precursor cells, were isolated from these depots to study whether intrinsic factors control BAT-like properties of the adipose tissue depots. RESULTS: When average outside temperature a week before harvesting was below 11  C, brown-like adipocytes expressing @entity3 were present in perirenal adipose tissue of @entity0 , but not of @entity0 . MSCs derived from perirenal adipose tissue expressed significantly more @entity3 when from female origin compared to male origin (P   =   0.009). However, @entity3 protein content and @entity1 consumption rate did not differ between adipocytes derived from male and female perirenal MSCs. CONCLUSIONS: Female perirenal adipose tissue has a higher potency to gain BAT-like properties than male perirenal adipose tissue. The degree of gaining BAT-like properties depends on sex-specific intrinsic factors and environmental triggers such as temperature.

title: XXXX have more potential to induce browning of perirenal adipose tissue than @entity0 .

answer: @entity0


abstract: OBJECTIVE: Brown adipose tissue (BAT) can generate heat by burning @entity4 , a process mediated by @entity3 ( @entity3 ). @entity2 ( @entity2 ) depots can gain BAT-like properties, and various studies have suggested that females have more active BAT or BAT-like @entity2 . We studied sex differences in BAT-like properties of @entity0 perirenal adipose tissue. METHODS: Perirenal and subcutaneous adipose tissue was obtained from 20 male and 24 female healthy live kidney donors. Mesenchymal stem cells (MSCs), adipocyte precursor cells, were isolated from these depots to study whether intrinsic factors control BAT-like properties of the adipose tissue depots. RESULTS: When average outside temperature a week before harvesting was below 11  C, brown-like adipocytes expressing @entity3 were present in perirenal adipose tissue of @entity0 , but not of @entity0 . MSCs derived from perirenal adipose tissue expressed significantly more @entity3 when from female origin compared to male origin (P   =   0.009). However, @entity3 protein content and @entity1 consumption rate did not differ between adipocytes derived from male and female perirenal MSCs. CONCLUSIONS: Female perirenal adipose tissue has a higher potency to gain BAT-like properties than male perirenal adipose tissue. The degree of gaining BAT-like properties depends on sex-specific intrinsic factors and environmental triggers such as temperature.

title: @entity0 have more potential to induce browning of perirenal adipose tissue than XXXX .

answer: @entity0


abstract: Pathological levels of @entity0 ( @entity0 ) have been implicated in a broad spectrum of diseases. Carbonylation is an irreversible post translational modification that is considered as a universal indicator of @entity0 . The development of new enrichment techniques coupled with the introduction of highly sensitive mass spectrometers has allowed the identification of carbonylated proteins in biological systems. In this study Deng et  al.(Proteomics 2015, 15, xxx-yyy) utilized one of these methods to isolate and identify carbonylated proteins that are involved in @entity1 -induced @entity2 . They identified 26 proteins that are targets of @entity0 and most of them were located in the mitochondria. A key carbonylated protein that was identified is long-chain specific @entity4 dehydrogenase ( @entity5 ) which has a major role in the b-oxidation of @entity3 . The researchers concluded that @entity1 -induced @entity2 is a two-step process which involves lipid overload followed by @entity0 . This article is protected by copyright. All rights reserved.

title: Redox proteomic investigation of XXXX -induced @entity2 .

answer: @entity1


abstract: Pathological levels of @entity0 ( @entity0 ) have been implicated in a broad spectrum of diseases. Carbonylation is an irreversible post translational modification that is considered as a universal indicator of @entity0 . The development of new enrichment techniques coupled with the introduction of highly sensitive mass spectrometers has allowed the identification of carbonylated proteins in biological systems. In this study Deng et  al.(Proteomics 2015, 15, xxx-yyy) utilized one of these methods to isolate and identify carbonylated proteins that are involved in @entity1 -induced @entity2 . They identified 26 proteins that are targets of @entity0 and most of them were located in the mitochondria. A key carbonylated protein that was identified is long-chain specific @entity4 dehydrogenase ( @entity5 ) which has a major role in the b-oxidation of @entity3 . The researchers concluded that @entity1 -induced @entity2 is a two-step process which involves lipid overload followed by @entity0 . This article is protected by copyright. All rights reserved.

title: Redox proteomic investigation of @entity1 -induced XXXX .

answer: @entity2


abstract: AIM: The aim of this study is to assess if a clinical diagnosis of nonspecific @entity1 (NSAP) is safe and if @entity0 with this initial diagnosis are likely to require further investigation or surgical intervention. METHODS: 3323 @entity0 admitted with NSAP from July 1990 to September 2012 utilizing a prospective database of all surgical admissions were included. Readmission over the period of the study and specifically within 30days of their initial presentation was identified together with any invasive investigation or surgical intervention. MAIN RESULTS: 319 @entity0 (9.6%) were subsequently readmitted with @entity1 at some point during the study period. Of these, 78 (2.3%) were readmitted within 30days. 118 (3.5%) @entity0 subsequently had an operation or invasive investigation some point following their initial admission. Of these 33 (0.6%) had the procedure within 3months of the initial admission. 13 @entity0 had an appendicectomy within 3months of the initial presentation. Of these histology confirmed @entity2 in 8 @entity0 . This gives an overall incidence of "missed" @entity2 of 0.2 % (8/3323). CONCLUSION: This study confirms that a clinical diagnosis of nonspecific @entity1 (NSAP) is safe in a pediatric population and the risk of "missing" @entity2 is only 0.2%. @entity0 and/or parents can be confidently reassured that the risk of missing organic pathology is very low.

title: Nonspecific XXXX is a safe diagnosis.

answer: @entity1


abstract: BACKGROUND/PURPOSE: Gonadotropin releasing hormone( @entity3 ) as an adjunct to orchidopexy for the treatment of @entity1 is still controversial. Present evidences were studied through a meta-analysis of comparative clinical trials. METHOD: Systematic literature search was done up to September 30, 2013. Studies were independently appraised by two reviewers. Continuous data of fertility indices were extracted as @entity2 ( @entity2 ) and standard deviation (SD); while nominal data of fertility indices were extracted as relative risk (RR). Random effects model was used to analyze the pooled effect estimates. Inter-study heterogeneity and publication bias were assessed. PROSPERO Protocol registration (CRD42013004922). RESULTS: Ten eligible studies were included. The pooled effect estimates showed that cryptorchid @entity0 treated with @entity3 when compared with controls, have significantly increased germ cell per tubule ( @entity2 : 0.35; 95% CI 0.07-0.62, P=0.01) and increased RR to have normal value of germ cell per tubule (RR: 2.86; 95% CI 1.73-4.71, P<0.0001). Inter-study heterogeneity was noted, source identified with subgroup analysis. Publication bias was not evident. No @entity3 related adverse events were reported in all studies. CONCLUSION: Evidence suggests that a subset of @entity0 with @entity1 may benefit from @entity3 as adjunctive to orchidopexy in improving the fertility index. However, future studies are recommended to specifically identify subgroup characteristics of @entity1 that will clearly benefit from the treatment.

title: Hormonal therapy using gonadotropin releasing hormone for improvement of fertility index among @entity0 with XXXX : a meta-analysis and systematic review.

answer: @entity1


abstract: BACKGROUND/PURPOSE: Gonadotropin releasing hormone( @entity3 ) as an adjunct to orchidopexy for the treatment of @entity1 is still controversial. Present evidences were studied through a meta-analysis of comparative clinical trials. METHOD: Systematic literature search was done up to September 30, 2013. Studies were independently appraised by two reviewers. Continuous data of fertility indices were extracted as @entity2 ( @entity2 ) and standard deviation (SD); while nominal data of fertility indices were extracted as relative risk (RR). Random effects model was used to analyze the pooled effect estimates. Inter-study heterogeneity and publication bias were assessed. PROSPERO Protocol registration (CRD42013004922). RESULTS: Ten eligible studies were included. The pooled effect estimates showed that cryptorchid @entity0 treated with @entity3 when compared with controls, have significantly increased germ cell per tubule ( @entity2 : 0.35; 95% CI 0.07-0.62, P=0.01) and increased RR to have normal value of germ cell per tubule (RR: 2.86; 95% CI 1.73-4.71, P<0.0001). Inter-study heterogeneity was noted, source identified with subgroup analysis. Publication bias was not evident. No @entity3 related adverse events were reported in all studies. CONCLUSION: Evidence suggests that a subset of @entity0 with @entity1 may benefit from @entity3 as adjunctive to orchidopexy in improving the fertility index. However, future studies are recommended to specifically identify subgroup characteristics of @entity1 that will clearly benefit from the treatment.

title: Hormonal therapy using gonadotropin releasing hormone for improvement of fertility index among XXXX with @entity1 : a meta-analysis and systematic review.

answer: @entity0


abstract: @entity6 is most widely used for suppression of recurrent @entity3 by IV application. Advantages are good control and low incidence of signs of @entity4 . Most important disadvantage is lack of possibility to continue therapy by oral administration. A serious problem is a high rate of non-responders, between 15 and 50% according to the literature. In our @entity0 , rate of non-responders is about 25%. In these patients, other antiarrhythmic agents can be used, but therapeutic success is even more uncertain because of a higher rate of non-responders and adverse reactions in most instances. We administered @entity5 as drug of second choice in 30 @entity0 with @entity3 refractory to @entity6 . Initial bolus injection of 1-2 mg/kg body weight followed by drip infusion (0,2-0,5 mg/kg body weight/hr) or oral administration in those @entity0 who responded to the initial bolus injection (83%). This regimen allowed sufficient control of the @entity2 in all @entity0 of the responder group. Serious adverse reactions of cardiac origin were fall of blood pressure and exorbitant widening of QRS-complexes in three @entity0 . A demonstration of a @entity0 dying from pump failure with extremely widened QRS-complexes is given. Therefore we ask for caution regarding administration of @entity5 in @entity0 with serious diffuse @entity1 . @entity5 therefore seems to be well suited for therapy of @entity3 refractory to @entity6 because of its low rate of non-responders and the possibility to continue treatment of oral administration of the drug.

title: [Therapy of @entity3 refractory to XXXX with @entity5 (author's transl)].

answer: @entity6


abstract: @entity6 is most widely used for suppression of recurrent @entity3 by IV application. Advantages are good control and low incidence of signs of @entity4 . Most important disadvantage is lack of possibility to continue therapy by oral administration. A serious problem is a high rate of non-responders, between 15 and 50% according to the literature. In our @entity0 , rate of non-responders is about 25%. In these patients, other antiarrhythmic agents can be used, but therapeutic success is even more uncertain because of a higher rate of non-responders and adverse reactions in most instances. We administered @entity5 as drug of second choice in 30 @entity0 with @entity3 refractory to @entity6 . Initial bolus injection of 1-2 mg/kg body weight followed by drip infusion (0,2-0,5 mg/kg body weight/hr) or oral administration in those @entity0 who responded to the initial bolus injection (83%). This regimen allowed sufficient control of the @entity2 in all @entity0 of the responder group. Serious adverse reactions of cardiac origin were fall of blood pressure and exorbitant widening of QRS-complexes in three @entity0 . A demonstration of a @entity0 dying from pump failure with extremely widened QRS-complexes is given. Therefore we ask for caution regarding administration of @entity5 in @entity0 with serious diffuse @entity1 . @entity5 therefore seems to be well suited for therapy of @entity3 refractory to @entity6 because of its low rate of non-responders and the possibility to continue treatment of oral administration of the drug.

title: [Therapy of XXXX refractory to @entity6 with @entity5 (author's transl)].

answer: @entity3


abstract: @entity6 is most widely used for suppression of recurrent @entity3 by IV application. Advantages are good control and low incidence of signs of @entity4 . Most important disadvantage is lack of possibility to continue therapy by oral administration. A serious problem is a high rate of non-responders, between 15 and 50% according to the literature. In our @entity0 , rate of non-responders is about 25%. In these patients, other antiarrhythmic agents can be used, but therapeutic success is even more uncertain because of a higher rate of non-responders and adverse reactions in most instances. We administered @entity5 as drug of second choice in 30 @entity0 with @entity3 refractory to @entity6 . Initial bolus injection of 1-2 mg/kg body weight followed by drip infusion (0,2-0,5 mg/kg body weight/hr) or oral administration in those @entity0 who responded to the initial bolus injection (83%). This regimen allowed sufficient control of the @entity2 in all @entity0 of the responder group. Serious adverse reactions of cardiac origin were fall of blood pressure and exorbitant widening of QRS-complexes in three @entity0 . A demonstration of a @entity0 dying from pump failure with extremely widened QRS-complexes is given. Therefore we ask for caution regarding administration of @entity5 in @entity0 with serious diffuse @entity1 . @entity5 therefore seems to be well suited for therapy of @entity3 refractory to @entity6 because of its low rate of non-responders and the possibility to continue treatment of oral administration of the drug.

title: [Therapy of @entity3 refractory to @entity6 with XXXX (author's transl)].

answer: @entity5


abstract: UNASSIGNED: Skin is commonly stored frozen and then thawed prior to use for in vitro permeation experiments. Does frozen storage of skin alter its barrier property? Numerous studies have found contradictory answers to this question. In this study, the steady-state flux and lag time of @entity4 ( @entity3 ) were measured for fresh @entity0 skin and skin frozen at -85  C for 1, 2, 3, 6, 9, 12, and 18 months with 10% @entity1 as a cryoprotective agent. No significant differences in steady-state flux were found between fresh and previously frozen samples (p = 0.6). For lag time, a significant (p = 0.002) difference was found among all groups, but comparisons with fresh skin were not significant. Does @entity1 have a cryoprotective effect? The steady-state flux and lag time of @entity3 and @entity2 were measured through @entity0 skin stored at -85  C for up to 12 months with and without 10% @entity1 . No significant differences in steady-state flux or lag time were found between samples stored with or without @entity1 for either @entity3 or @entity2 (p >=  0.17). These findings support the use of frozen skin to measure the passive permeation of chemicals in studies unconcerned with viability and metabolism. Published by S. Karger AG, Basel.

title: Effect of Frozen XXXX Epidermis Storage Duration and Cryoprotectant on Barrier Function Using Two Model Compounds.

answer: @entity0


abstract: Background: @entity1 risk is modifiable through many risk factors, one being healthy dietary habits. Fibre intake was associated with a reduced @entity1 risk in recent meta-analyses; however, data were contributed by relatively few studies, and few examined different @entity1 types.Methods:A total of 27   373 disease-free @entity0 were followed up for 14.4 years. Diet was assessed with a 217-item food frequency questionnaire and @entity1 cases were identified using English Hospital Episode Statistics and mortality records. Survival analysis was applied to assess the risk of total, ischaemic or @entity3 in relation to fibre intake.Results:A total of 135 @entity3 and 184 @entity1 cases were identified in addition to 138 cases where the @entity1 type was unknown or not recorded. Greater intake of total fibre, higher fibre density and greater soluble fibre, insoluble fibre and fibre from cereals were associated with a significantly lower risk for total @entity1 . For total @entity1 , the hazard ratio per 6   g/day total fibre intake was 0.89 (95% confidence intervals: 0.81-0.99). Different findings were observed for @entity3 and @entity1 in healthy-weight or overweight @entity0 . Total fibre, insoluble fibre and cereal fibre were inversely associated with @entity3 risk in overweight/obese @entity0 , and in healthy-weight @entity0 greater cereal fibre was associated with a lower @entity1 risk. In non- @entity2 @entity0 , higher fibre density was associated with lower @entity1 risk.Conclusions:Greater total fibre and fibre from cereals are associated with a lower @entity1 risk, and associations were more consistent with @entity1 . The different observations by @entity1 type, body mass index group or @entity2 status indicates potentially different mechanisms.European Journal of Clinical Nutrition advance online publication, 3 December 2014; doi:10.1038/ejcn.2014.260.

title: Dietary fibre intake and risk of ischaemic and XXXX in the UK @entity0 's Cohort Study.

answer: @entity3


abstract: Background: @entity1 risk is modifiable through many risk factors, one being healthy dietary habits. Fibre intake was associated with a reduced @entity1 risk in recent meta-analyses; however, data were contributed by relatively few studies, and few examined different @entity1 types.Methods:A total of 27   373 disease-free @entity0 were followed up for 14.4 years. Diet was assessed with a 217-item food frequency questionnaire and @entity1 cases were identified using English Hospital Episode Statistics and mortality records. Survival analysis was applied to assess the risk of total, ischaemic or @entity3 in relation to fibre intake.Results:A total of 135 @entity3 and 184 @entity1 cases were identified in addition to 138 cases where the @entity1 type was unknown or not recorded. Greater intake of total fibre, higher fibre density and greater soluble fibre, insoluble fibre and fibre from cereals were associated with a significantly lower risk for total @entity1 . For total @entity1 , the hazard ratio per 6   g/day total fibre intake was 0.89 (95% confidence intervals: 0.81-0.99). Different findings were observed for @entity3 and @entity1 in healthy-weight or overweight @entity0 . Total fibre, insoluble fibre and cereal fibre were inversely associated with @entity3 risk in overweight/obese @entity0 , and in healthy-weight @entity0 greater cereal fibre was associated with a lower @entity1 risk. In non- @entity2 @entity0 , higher fibre density was associated with lower @entity1 risk.Conclusions:Greater total fibre and fibre from cereals are associated with a lower @entity1 risk, and associations were more consistent with @entity1 . The different observations by @entity1 type, body mass index group or @entity2 status indicates potentially different mechanisms.European Journal of Clinical Nutrition advance online publication, 3 December 2014; doi:10.1038/ejcn.2014.260.

title: Dietary fibre intake and risk of ischaemic and @entity3 in the UK XXXX 's Cohort Study.

answer: @entity0


abstract: BACKGROUND: The involvement of MADS-box genes of the AGAMOUS lineage in the formation of both flowers and fruits has been studied in detail in Angiosperms. AGAMOUS genes are expressed also in the reproductive structures of Gymnosperms, yet the demonstration of their role has been problematic because Gymnosperms are woody plants difficult to manipulate for physiological and genetic studies. Recently, it was shown that in the gymnosperm @entity1 an AGAMOUS gene was expressed throughout development and ripening of the fleshy fruit-like structures produced by this species around its seeds. Such fleshy structures are evolutionarily very important because they favor the dispersal of seeds through endozoochory. In this work a characterization of the @entity1 gene was carried out by over-expressing it in @entity0 . RESULTS: In @entity0 plants ectopically expressing the @entity1 AGAMOUS gene a macroscopic anomaly was observed only in the flower sepals. While the wild type sepals had a leaf-like appearance, the transgenic ones appeared connately adjoined at their proximal extremity and, concomitant with the development and ripening of the fruit, they became thicker and acquired a yellowish-orange color, thus indicating that they had undergone a homeotic transformation into carpel-like structures. Molecular analyses of several genes associated with either the control of ripening or the ripening syndrome in @entity0 fruits confirmed that the transgenic sepals behaved like ectopic fruits that could undergo some ripening, although the red color typical of the ripe @entity0 fruit was never achieved. CONCLUSIONS: The ectopic expression of the @entity1 AGAMOUS gene in @entity0 caused the homeotic transformation of the transgenic sepals into carpel-like structures, and this showed that the gymnosperm gene has a genuine C function. In parallel with the ripening of fruits the related transgenic sepals became fleshy fruit-like structures that also underwent some ripening and such a result indicates that this C function gene might be involved, together with other gens, also in the development of the @entity1 fruit-like structures. It seems thus strengthened the hypothesis that AGAMOUS MADS-box genes were recruited already in Gymnosperms for the development of the fleshy fruit habit which is evolutionarily so important for the dispersal of seeds.

title: Characterization of an AGAMOUS gene expressed throughout development of the fleshy fruit-like structure produced by XXXX around its seeds.

answer: @entity1


abstract: BACKGROUND: Fine-needle aspiration cytology (FNAC) of oral lesions has not been widely utilized for diagnosis due to rarity and diversity of lesions, peculiar anatomy of maxillofacial region, difficulty in aspirating these lesions, and limited experience. Aim of this study was to determine the role of FNAC in the diagnosis of @entity3 . MATERIALS AND METHODS: One hundred and forty two @entity0 underwent FNAC over a period of 7 years (2007-2013), of which 127 (89.4%) aspirates were diagnostic. Histopathologic correlation was available in 83 cases and diagnostic accuracy of FNAC was calculated. RESULTS: Of the minor salivary gland lesions, 41 out of 55 lesions (74.5%) were benign and 14 (25.4%) were malignant. Mucocele was the most common lesion in oral cavity (30 cases) and @entity8 was the commonest @entity11 (9 cases). Of the 72 non-salivary-gland lesions, 22 lesions were inflammatory, 4 were epidermal inclusion cysts, 21 were @entity1 , and the remaining 25 presented as radiolucent jaw @entity2 . Diagnostic accuracy of FNAC in our study was 91.6% with 6 false negatives and 1 false positive. Four @entity1 and one case of cystic @entity6 were misdiagnosed as false negative on cytology. CONCLUSION: Cytological features are diagnostic in certain inflammatory lesions of infective etiology and @entity1 conditions like Langerhans cell histiocytosis, @entity4 , @entity10 , @entity7 , and @entity5 . However, accurate subtyping of giant cell lesions, @entity1 , odontogenic @entity1 , and @entity9 may not be always feasible on FNAC. FNAC is highly accurate in early diagnosis of @entity3 .

title: Diagnostic role and limitations of FNAC in XXXX .

answer: @entity3


abstract: BACKGROUND: Ethiopia has scaled up its community-based programs over the past decade by training and deploying @entity2 ( @entity2 ) in rural communities throughout the country. Consequently, @entity0 mortality has declined substantially, placing Ethiopia among the few countries that have achieved the United Nations' fourth Millennium Development Goal. As Ethiopia continues its efforts, results must be assessed regularly to provide timely feedback for improvement and to generate further support for programs. More specifically the expansion of @entity2 at the community level provides a unique opportunity to build a system for real-time monitoring of births and @entity1 , linked to a civil registration and vital statistics system that Ethiopia is also developing. We tested the accuracy and @entity3 and @entity1 reported by trained @entity2 for monitoring @entity0 mortality over 15 -month periods. METHODS AND FINDINGS: @entity2 were trained in 93 randomly selected rural kebeles in Jimma and West Hararghe zones of the Oromia region to report births and @entity1 over a 15-month period from January, 2012 to March, 2013. @entity4 of births and @entity1 , age distribution of @entity1 , and accuracy of resulting under-five, @entity0 , and neonatal mortality rates were assessed against data from a large household survey with full birth history from @entity0 aged 15-49. Although, in general @entity2 , were able to accurately report events that they identified, the completeness of number of births and @entity1 reported over twelve-month periods was very low and variable across the two zones. Compared to household survey estimates, @entity2 reported only about 30% of births and 21% of under-five @entity1 occurring in their communities over a twelve-month period. The under-five mortality rate was under-estimated by around 30%, @entity0 mortality rate by 23% and neonatal mortality by 17%. @entity2 reported disproportionately higher number of @entity1 among the very young @entity0 than among the older @entity0 . CONCLUSION: Birth and @entity1 data reported by @entity2 are not complete enough to support the monitoring of changes in childhood mortality. @entity2 can significantly contribute to the success of a CRVS in Ethiopia, but cannot be relied upon as the sole source for identification of vital events. Further studies are needed to understand how to increase the level of completeness.

title: Using Health Extension Workers for Monitoring XXXX Mortality in Real-Time: Validation against Household Survey Data in Rural Ethiopia.

answer: @entity0


abstract: @entity13 , @entity12 , and @entity14 are antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. The induction of @entity11 gene expression including @entity7 and @entity8 is mediated by the transformation of @entity3 ( @entity4 ), and modulated by @entity10 ( @entity10 ). @entity7 is expressed in the liver, pancreas, thymus, uterus, and small intestine. @entity8 is abundant in the prostate, breast, and uterus. Expression levels of @entity7 and @entity8 indicate @entity4 -induced immunotoxicity, oxidative stress, and activation of environmental carcinogens. In this study, the ability of cell viability was examined as @entity1 assay by pesticides; @entity13 , @entity12 and @entity14 . In addition, expression levels of mRNA and protein of @entity10 , @entity7 , and @entity9 were analysed by RT-PCR and Western blot analysis in BG-1 @entity0 cells with @entity5 receptors (ER). To evaluate the ability of cell viability, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 1*10(-9)M), @entity13 , @entity12 or @entity14 (10(-5)-10(-8)M). To evaluate the expression levels of mRNA and protein, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 10(-9)M) and these pesticides (10(-5)M). As results, E2 as a positive control markedly increased BG-1 cell viability ~5 times compared to a negative control (P<0.05). In addition, treatments with these pesticides increased BG-1 cell viability at the concentrations of 10(-8) and 10(-5)M about from 1.5 to 2 times, respectively (P<0.05). When respective treatment co-treated with @entity2 , an ER antagonist, BG-1 cell viability was reversed to the level of a negative control. The mRNA expression of @entity7 was increased by E2, @entity13 , and @entity14 in a time-dependent manner but not by @entity12 , while its level was reversed in the presence of @entity2 . In parallel with their transcriptional levels, protein levels of @entity7 and @entity9 were induced by E2 and these pesticides, while the level of @entity10 was not altered by E2 and these pesticides. Taken together, these results imply that the pesticides, @entity13 , @entity12 , and @entity14 , may have disruptive effects on ER expressing cells or tissues by alteration of @entity7 and @entity9 via an ER-dependent pathway.

title: 222 antifungal agents as agricultural products, XXXX , @entity12 , and @entity14 , induced the expression of cytochrome p450 family and cell cycle-related genes in estrogen receptor expressing bg-1 @entity0 cells.

answer: @entity13


abstract: @entity13 , @entity12 , and @entity14 are antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. The induction of @entity11 gene expression including @entity7 and @entity8 is mediated by the transformation of @entity3 ( @entity4 ), and modulated by @entity10 ( @entity10 ). @entity7 is expressed in the liver, pancreas, thymus, uterus, and small intestine. @entity8 is abundant in the prostate, breast, and uterus. Expression levels of @entity7 and @entity8 indicate @entity4 -induced immunotoxicity, oxidative stress, and activation of environmental carcinogens. In this study, the ability of cell viability was examined as @entity1 assay by pesticides; @entity13 , @entity12 and @entity14 . In addition, expression levels of mRNA and protein of @entity10 , @entity7 , and @entity9 were analysed by RT-PCR and Western blot analysis in BG-1 @entity0 cells with @entity5 receptors (ER). To evaluate the ability of cell viability, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 1*10(-9)M), @entity13 , @entity12 or @entity14 (10(-5)-10(-8)M). To evaluate the expression levels of mRNA and protein, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 10(-9)M) and these pesticides (10(-5)M). As results, E2 as a positive control markedly increased BG-1 cell viability ~5 times compared to a negative control (P<0.05). In addition, treatments with these pesticides increased BG-1 cell viability at the concentrations of 10(-8) and 10(-5)M about from 1.5 to 2 times, respectively (P<0.05). When respective treatment co-treated with @entity2 , an ER antagonist, BG-1 cell viability was reversed to the level of a negative control. The mRNA expression of @entity7 was increased by E2, @entity13 , and @entity14 in a time-dependent manner but not by @entity12 , while its level was reversed in the presence of @entity2 . In parallel with their transcriptional levels, protein levels of @entity7 and @entity9 were induced by E2 and these pesticides, while the level of @entity10 was not altered by E2 and these pesticides. Taken together, these results imply that the pesticides, @entity13 , @entity12 , and @entity14 , may have disruptive effects on ER expressing cells or tissues by alteration of @entity7 and @entity9 via an ER-dependent pathway.

title: 222 antifungal agents as agricultural products, @entity13 , XXXX , and @entity14 , induced the expression of cytochrome p450 family and cell cycle-related genes in estrogen receptor expressing bg-1 @entity0 cells.

answer: @entity12


abstract: @entity13 , @entity12 , and @entity14 are antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. The induction of @entity11 gene expression including @entity7 and @entity8 is mediated by the transformation of @entity3 ( @entity4 ), and modulated by @entity10 ( @entity10 ). @entity7 is expressed in the liver, pancreas, thymus, uterus, and small intestine. @entity8 is abundant in the prostate, breast, and uterus. Expression levels of @entity7 and @entity8 indicate @entity4 -induced immunotoxicity, oxidative stress, and activation of environmental carcinogens. In this study, the ability of cell viability was examined as @entity1 assay by pesticides; @entity13 , @entity12 and @entity14 . In addition, expression levels of mRNA and protein of @entity10 , @entity7 , and @entity9 were analysed by RT-PCR and Western blot analysis in BG-1 @entity0 cells with @entity5 receptors (ER). To evaluate the ability of cell viability, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 1*10(-9)M), @entity13 , @entity12 or @entity14 (10(-5)-10(-8)M). To evaluate the expression levels of mRNA and protein, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 10(-9)M) and these pesticides (10(-5)M). As results, E2 as a positive control markedly increased BG-1 cell viability ~5 times compared to a negative control (P<0.05). In addition, treatments with these pesticides increased BG-1 cell viability at the concentrations of 10(-8) and 10(-5)M about from 1.5 to 2 times, respectively (P<0.05). When respective treatment co-treated with @entity2 , an ER antagonist, BG-1 cell viability was reversed to the level of a negative control. The mRNA expression of @entity7 was increased by E2, @entity13 , and @entity14 in a time-dependent manner but not by @entity12 , while its level was reversed in the presence of @entity2 . In parallel with their transcriptional levels, protein levels of @entity7 and @entity9 were induced by E2 and these pesticides, while the level of @entity10 was not altered by E2 and these pesticides. Taken together, these results imply that the pesticides, @entity13 , @entity12 , and @entity14 , may have disruptive effects on ER expressing cells or tissues by alteration of @entity7 and @entity9 via an ER-dependent pathway.

title: 222 antifungal agents as agricultural products, @entity13 , @entity12 , and XXXX , induced the expression of cytochrome p450 family and cell cycle-related genes in estrogen receptor expressing bg-1 @entity0 cells.

answer: @entity14


abstract: @entity13 , @entity12 , and @entity14 are antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. The induction of @entity11 gene expression including @entity7 and @entity8 is mediated by the transformation of @entity3 ( @entity4 ), and modulated by @entity10 ( @entity10 ). @entity7 is expressed in the liver, pancreas, thymus, uterus, and small intestine. @entity8 is abundant in the prostate, breast, and uterus. Expression levels of @entity7 and @entity8 indicate @entity4 -induced immunotoxicity, oxidative stress, and activation of environmental carcinogens. In this study, the ability of cell viability was examined as @entity1 assay by pesticides; @entity13 , @entity12 and @entity14 . In addition, expression levels of mRNA and protein of @entity10 , @entity7 , and @entity9 were analysed by RT-PCR and Western blot analysis in BG-1 @entity0 cells with @entity5 receptors (ER). To evaluate the ability of cell viability, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 1*10(-9)M), @entity13 , @entity12 or @entity14 (10(-5)-10(-8)M). To evaluate the expression levels of mRNA and protein, BG-1 cells were cultured with a negative control (0.1% @entity6 ), 17b-oestradiol (E2; 10(-9)M) and these pesticides (10(-5)M). As results, E2 as a positive control markedly increased BG-1 cell viability ~5 times compared to a negative control (P<0.05). In addition, treatments with these pesticides increased BG-1 cell viability at the concentrations of 10(-8) and 10(-5)M about from 1.5 to 2 times, respectively (P<0.05). When respective treatment co-treated with @entity2 , an ER antagonist, BG-1 cell viability was reversed to the level of a negative control. The mRNA expression of @entity7 was increased by E2, @entity13 , and @entity14 in a time-dependent manner but not by @entity12 , while its level was reversed in the presence of @entity2 . In parallel with their transcriptional levels, protein levels of @entity7 and @entity9 were induced by E2 and these pesticides, while the level of @entity10 was not altered by E2 and these pesticides. Taken together, these results imply that the pesticides, @entity13 , @entity12 , and @entity14 , may have disruptive effects on ER expressing cells or tissues by alteration of @entity7 and @entity9 via an ER-dependent pathway.

title: 222 antifungal agents as agricultural products, @entity13 , @entity12 , and @entity14 , induced the expression of cytochrome p450 family and cell cycle-related genes in estrogen receptor expressing bg-1 XXXX cells.

answer: @entity0


abstract: Aim. To estimate the clinical significance of anti- @entity2 receptor antibody (anti-AChR-Ab) levels in suspected @entity4 . Methods. In total, 144 @entity0 complaining of fluctuating @entity1 and @entity3 were evaluated for serum levels of anti- @entity2 receptor antibody and their medical charts were retrospectively reviewed. Subjects were classified into three groups: variable @entity1 only, @entity3 only, and both variable @entity1 and @entity3 . We investigated serum anti-AChR-Ab titer levels and performed thyroid autoantibody tests. Results. @entity0 ' chief complaints were @entity1 (N = 103), @entity3 (N = 12), and their concurrence (N = 29). Abnormal anti-AChR-Ab was observed in 21 of 144 @entity0 (14.1%). Between the three groups, mean age, number of seropositive @entity0 , and mean anti-AChR-Ab level were not significantly different (P = 0.224, 0.073, and 0.062, resp.). Overall, 27.5% of @entity0 had abnormal thyroid autoantibodies. Conclusion. The sensitivity of anti-AChR-Ab was 14.1% in suspected @entity4 and seropositivity in @entity4 @entity0 showed a high correlation with the presence of thyroid autoantibodies.

title: The anti- @entity2 receptor antibody test in suspected XXXX .

answer: @entity4


abstract: Aim. To estimate the clinical significance of anti- @entity2 receptor antibody (anti-AChR-Ab) levels in suspected @entity4 . Methods. In total, 144 @entity0 complaining of fluctuating @entity1 and @entity3 were evaluated for serum levels of anti- @entity2 receptor antibody and their medical charts were retrospectively reviewed. Subjects were classified into three groups: variable @entity1 only, @entity3 only, and both variable @entity1 and @entity3 . We investigated serum anti-AChR-Ab titer levels and performed thyroid autoantibody tests. Results. @entity0 ' chief complaints were @entity1 (N = 103), @entity3 (N = 12), and their concurrence (N = 29). Abnormal anti-AChR-Ab was observed in 21 of 144 @entity0 (14.1%). Between the three groups, mean age, number of seropositive @entity0 , and mean anti-AChR-Ab level were not significantly different (P = 0.224, 0.073, and 0.062, resp.). Overall, 27.5% of @entity0 had abnormal thyroid autoantibodies. Conclusion. The sensitivity of anti-AChR-Ab was 14.1% in suspected @entity4 and seropositivity in @entity4 @entity0 showed a high correlation with the presence of thyroid autoantibodies.

title: The anti- XXXX receptor antibody test in suspected @entity4 .

answer: @entity2


abstract: UNASSIGNED: The @entity3 ( @entity3 ) is a unique structure in the brain that forms an interface between the peripheral blood and the cerebrospinal fluid (CSF) which is mostly produced by the @entity3 itself. Since the @entity3 transcriptome is regulated by the sex hormone background, the goal of this study was to compare gene/ protein expression profiles in the @entity3 and CSF from male and female @entity1 to better understand sex related differences in @entity3 functions and brain physiology. We used data previously obtained by cDNA microarrays to compare the @entity3 transcriptome between male and female @entity1 , and complemented these data with the proteomic analysis of the CSF of castrated and sham-operated males and females. Microarray analysis showed that 17128 and 17002 genes are expressed in the male and female @entity3 , what allowed the functional annotation of 141 and 134 pathways, respectively. Among the most expressed genes, canonical pathways associated with @entity2 and oxidative phosphorylation were the most prominent, while the most relevant molecular and cellular functions annotated were protein synthesis, cellular growth and proliferation, cell death and survival, molecular transport and protein trafficking. No significant differences were found between males and females regarding these pathways. Seminal functions of the @entity3 differentially regulated between sexes were the circadian rhythm signalling, and several canonical pathways related to stem cell differentiation, metabolism, and the barrier function of the @entity3 . The proteomic analysis identified 5 down-regulated proteins in the CSF samples from male @entity1 compared with females and 7 proteins exhibiting marked variation in the CSF of gonadectomised males in comparison to sham animals, whereas no differences were found between sham and ovariectomized females. These data clearly show sex related differences in the @entity3 gene expression and in the CSF protein composition that may impact on @entity0 . This article is protected by copyright. All rights reserved.

title: Sex related differences in XXXX choroid plexus and cerebrospinal fluid: a cDNA microarray and proteomic analysis.

answer: @entity1


abstract: UNASSIGNED: The development of @entity2 after non-exhaustive and exhaustive exercise eliciting differing metabolic demands is poorly understood. Sixteen active males completed five cycling trials. The first trial established the @entity1 threshold (LT) and maximal @entity0 uptake (VO2max ). Two of the remaining trials were completed at a severe intensity (halfway between LT and VO2max , SI) and two at a moderate intensity (90% LT, MI). Each trial involved two non-exhaustive bouts matched for work between intensities before cycling to exhaustion. Responses to stimulation of the femoral nerve and motor cortex were determined after each bout to determine peripheral and central @entity2 . @entity4 , cortical silent period (cSP), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were also assessed. Non-exhaustive cycling induced greater peripheral and central @entity2 in the SI compared with the MI (P   <   0.05). At exhaustion, there was no difference between intensities; however, @entity3 tended to be greater in the SI vs MI (-31% vs -17%, respectively, P   =   0.051). Exhaustive cycling increased SICI (24%, P   <   0.001) and reduced the cSP (-14%, P   <   0.001) in the SI, whereas ICF was reduced in the MI (-16%, P   <   0.001). These findings demonstrate exercise-induced metabolic stress accelerates the development of peripheral and central @entity2 , and differentially influences intracortical excitability.

title: Central and XXXX following non-exhaustive and exhaustive exercise of disparate metabolic demands.

answer: @entity3


abstract: BACKGROUND: The prognosis and chemoresistance of signet-ring cell (SRC) @entity3 have been reported and debated, and the utility of perioperative chemotherapy for such a @entity1 has been questioned . This study was performed to assess the impact of the SRC type on survival following resection of @entity3 , and to assess whether the prognostic factors (including perioperative chemotherapy) for non-SRC @entity4 differed from those for SRC @entity4 . METHODS: 1799 cases of @entity4 that were consecutively treated from 1997 to 2010 in 19 French centers by subtotal or total gastrectomy were included in a retrospective study. A D2 lymphadenectomy was performed for @entity1 , and a modified D2 for upper @entity1 . SRC @entity4 was diagnosed based on the presence of @entity2 cells containing mucin. RESULTS: A total gastrectomy was performed in 979 (54.4  %) @entity0 . SRC @entity4 was diagnosed in 899 (50  %) @entity0 . @entity0 with an SRC @entity1 were more frequently female, younger, and malnourished, had lower ASA scores, and had larger @entity1 than non-SRC @entity0 . Median survival in @entity0 with @entity5 was 51  months, as compared to 26  months in @entity0 with @entity5 (p  <  0.001). At multivariate analysis, SRC type remained an independent adverse prognostic factor (HR  =  1.182). Factors that were prognostic in the SRC subgroup but not in the non-SRC subgroup were age >60  years, linitis, and involvement of adjacent organs. In contrast to non-SRC @entity1 , pre- and postoperative chemotherapy did not significantly impact on survival following resection of SRC @entity4 . CONCLUSION: In comparison to non-SRC @entity4 , the SRC type has a worse prognosis, different prognostic factors, and is only poorly sensitive to perioperative chemotherapy. Non-SRC and SRC @entity4 should be considered different entities in future therapeutic trials.

title: Is XXXX a specific entity among @entity3 ?

answer: @entity5


abstract: BACKGROUND: The prognosis and chemoresistance of signet-ring cell (SRC) @entity3 have been reported and debated, and the utility of perioperative chemotherapy for such a @entity1 has been questioned . This study was performed to assess the impact of the SRC type on survival following resection of @entity3 , and to assess whether the prognostic factors (including perioperative chemotherapy) for non-SRC @entity4 differed from those for SRC @entity4 . METHODS: 1799 cases of @entity4 that were consecutively treated from 1997 to 2010 in 19 French centers by subtotal or total gastrectomy were included in a retrospective study. A D2 lymphadenectomy was performed for @entity1 , and a modified D2 for upper @entity1 . SRC @entity4 was diagnosed based on the presence of @entity2 cells containing mucin. RESULTS: A total gastrectomy was performed in 979 (54.4  %) @entity0 . SRC @entity4 was diagnosed in 899 (50  %) @entity0 . @entity0 with an SRC @entity1 were more frequently female, younger, and malnourished, had lower ASA scores, and had larger @entity1 than non-SRC @entity0 . Median survival in @entity0 with @entity5 was 51  months, as compared to 26  months in @entity0 with @entity5 (p  <  0.001). At multivariate analysis, SRC type remained an independent adverse prognostic factor (HR  =  1.182). Factors that were prognostic in the SRC subgroup but not in the non-SRC subgroup were age >60  years, linitis, and involvement of adjacent organs. In contrast to non-SRC @entity1 , pre- and postoperative chemotherapy did not significantly impact on survival following resection of SRC @entity4 . CONCLUSION: In comparison to non-SRC @entity4 , the SRC type has a worse prognosis, different prognostic factors, and is only poorly sensitive to perioperative chemotherapy. Non-SRC and SRC @entity4 should be considered different entities in future therapeutic trials.

title: Is @entity5 a specific entity among XXXX ?

answer: @entity3


abstract: INTRODUCTION: Unstable inter-trochanteric fracture in the geriatric population is a common injury and is associated with poor bone quality, @entity5 , @entity4 , and cut-out of the lag screw, are the common problems of attempts to fix these @entity3 . Present study is an attempt to evaluate the functional outcome of @entity2 in unstable inter-trochanteric @entity3 in elderly @entity0 . MATERIALS AND METHODS: This prospective study included 25 cases with unstable inter-trochanteric fracture of femur between 60 -75 y of age in whom primary Cemented Bipolar hemi - arthroplasty was performed. The @entity0 were followed up at six week, three month, six month and one year postoperatively and assessed using Harris Hip Score (HHS), Lower Extremity Functional Scale (LEFS), Visual analogue scale (VAS) for evaluation of outcome. RESULTS: The mean HHS score was 78.86+8.13 by the end of one year. Similarly mean LEFS score was 34.36+7.01 by the end of one year, whereas the mean @entity1 score on VAS Scale by the year end was 1.04+1.02. DISCUSSION: The changes in HHS, LEFS and VAS up to six months periods are much greater which starts showing a stable trend thereafter. Fair to good scores were observed in all the @entity0 . We compared our results with those reported by other authors and our study gave quite comparable results. We also used lower extremity function status score (LEFS) for assessment of functional ability. The purpose of its use was that while Harris Hip Score (HHS) provides information on a multitude of factors, LEFS is more @entity0 oriented and provides the correct information about the level of activities a @entity0 can resume post-operatively and can be offered as a self assessment tool. No significant complication except for grade I pressure sores in four @entity0 were seen in postoperative period but they all resolved with proper nursing care by six week follow up. No @entity0 required revision surgery. CONCLUSION: The authors believe that @entity2 for unstable inter-trochanteric @entity3 of femur in elderly does provide early ambulation, good functional outcome, @entity1 free joint with minimal complications without the need for revision surgery.

title: Hemi replacement arthroplasty for unstable inter-trochanteric XXXX of femur.

answer: @entity3


abstract: BACKGROUND: Overhydration has a deleterious effect on cardio myocytes. This study was designated to evaluate @entity4 in @entity0 with various stages of @entity3 ( @entity3 ) using conventional, tissue Doppler and two-dimensional speckle tracking echocardiography (2DSTE). METHODS: Forty controls and 90 @entity3 @entity0 , aged 49.3    14 years old, were enrolled in the study. @entity0 were divided into 3 groups depending on their glomerular filtration rate. Group 1 (>= 60 mL/min per 1.73 m(2) ), group 2 ( <=60 mL/min per 1.73 m(2) ), and group 3 ( <=60 mL/min per 1.73 m(2) and on regular dialysis for at least 12 months). Pulsed-Doppler and tissue Doppler studies were used to estimate LV filling pressure E/E'. Using 2DSTE, circumferential, radial, and longitudinal functions of the LV have been measured. RESULTS: @entity4 , early, and late diastolic strain rates were significantly reduced in @entity3 @entity0 (-16.9    3.8%, 1.6    0.5%, and 1.3    0.4% in @entity3 vs. -22.5    0.6%, 2.3    0.2%, and 1.9    0.1% in controls, P < 0.001 for all), and no difference was observed in terms of the circumferential LV functions (-22.4    1.7 vs. -22.5    1.4, P = 0.567). Severity of the @entity1 appears to parallel with the rise of E/E' significantly (P < 0.001). CONCLUSION: In @entity3 , although the longitudinal and radial systolic functions were reduced, LV ejection fraction may remain within normal limits due to the preservation of the circumferential functions. Early detection of uremic @entity2 might provide useful information for the risk stratification and decide the proper dialysis therapy in these @entity0 .

title: Early Detection of Subclinical XXXX Using Two-Dimensional Speckle Tracking Echocardiography.

answer: @entity2


abstract: @entity3 size and @entity5 following @entity1 /reperfusion are reduced by inhibitors of the Na+, K+, 2Cl-, and water cotransporter @entity8 and by @entity4 antagonists. @entity8 is a secondary active transporter, mainly localized in astrocytes, driven by transmembrane Na+/K+ gradients generated by the Na+,K+-ATPase. The astrocytic Na+,K+-ATPase is stimulated by small increases in extracellular K+ concentration and by the b-adrenergic agonist @entity6 . Larger K+ increases, as occurring during @entity1 , also stimulate @entity8 , creating cell swelling. This study showed no @entity0 after 3   hr medial cerebral artery occlusion but pronounced @entity0 after 8   hr reperfusion. The @entity0 was abolished by inhibitors of specifically b1-adrenergic pathways, indicating failure of K+-mediated, but not @entity4 -mediated, stimulation of Na+,K+-ATPase/ @entity8 transport during reoxygenation. Ninety percent reduction of extracellular @entity2 concentration occurs in @entity1 . @entity2 omission abolished K+ uptake in normoxic cultures of astrocytes after addition of 5   mM @entity7 . A large decrease in ouabain potency on K+ uptake in cultured astrocytes was also demonstrated in @entity2 -depleted media, and endogenous ouabains are needed for astrocytic K+ uptake. Thus, among the ionic changes induced by @entity1 , the decrease in extracellular @entity2 causes failure of the high-K+-stimulated Na+,K+-ATPase/ @entity8 ion/water uptake, making b1-adrenergic activation the only stimulus and its inhibition effective against @entity0 .

title: Inhibition of @entity0 after @entity1 -reperfusion by b-adrenergic antagonists: correlation with increased K+ and decreased XXXX concentrations in extracellular fluid.

answer: @entity2


abstract: @entity3 size and @entity5 following @entity1 /reperfusion are reduced by inhibitors of the Na+, K+, 2Cl-, and water cotransporter @entity8 and by @entity4 antagonists. @entity8 is a secondary active transporter, mainly localized in astrocytes, driven by transmembrane Na+/K+ gradients generated by the Na+,K+-ATPase. The astrocytic Na+,K+-ATPase is stimulated by small increases in extracellular K+ concentration and by the b-adrenergic agonist @entity6 . Larger K+ increases, as occurring during @entity1 , also stimulate @entity8 , creating cell swelling. This study showed no @entity0 after 3   hr medial cerebral artery occlusion but pronounced @entity0 after 8   hr reperfusion. The @entity0 was abolished by inhibitors of specifically b1-adrenergic pathways, indicating failure of K+-mediated, but not @entity4 -mediated, stimulation of Na+,K+-ATPase/ @entity8 transport during reoxygenation. Ninety percent reduction of extracellular @entity2 concentration occurs in @entity1 . @entity2 omission abolished K+ uptake in normoxic cultures of astrocytes after addition of 5   mM @entity7 . A large decrease in ouabain potency on K+ uptake in cultured astrocytes was also demonstrated in @entity2 -depleted media, and endogenous ouabains are needed for astrocytic K+ uptake. Thus, among the ionic changes induced by @entity1 , the decrease in extracellular @entity2 causes failure of the high-K+-stimulated Na+,K+-ATPase/ @entity8 ion/water uptake, making b1-adrenergic activation the only stimulus and its inhibition effective against @entity0 .

title: Inhibition of @entity0 after XXXX -reperfusion by b-adrenergic antagonists: correlation with increased K+ and decreased @entity2 concentrations in extracellular fluid.

answer: @entity1


abstract: @entity3 size and @entity5 following @entity1 /reperfusion are reduced by inhibitors of the Na+, K+, 2Cl-, and water cotransporter @entity8 and by @entity4 antagonists. @entity8 is a secondary active transporter, mainly localized in astrocytes, driven by transmembrane Na+/K+ gradients generated by the Na+,K+-ATPase. The astrocytic Na+,K+-ATPase is stimulated by small increases in extracellular K+ concentration and by the b-adrenergic agonist @entity6 . Larger K+ increases, as occurring during @entity1 , also stimulate @entity8 , creating cell swelling. This study showed no @entity0 after 3   hr medial cerebral artery occlusion but pronounced @entity0 after 8   hr reperfusion. The @entity0 was abolished by inhibitors of specifically b1-adrenergic pathways, indicating failure of K+-mediated, but not @entity4 -mediated, stimulation of Na+,K+-ATPase/ @entity8 transport during reoxygenation. Ninety percent reduction of extracellular @entity2 concentration occurs in @entity1 . @entity2 omission abolished K+ uptake in normoxic cultures of astrocytes after addition of 5   mM @entity7 . A large decrease in ouabain potency on K+ uptake in cultured astrocytes was also demonstrated in @entity2 -depleted media, and endogenous ouabains are needed for astrocytic K+ uptake. Thus, among the ionic changes induced by @entity1 , the decrease in extracellular @entity2 causes failure of the high-K+-stimulated Na+,K+-ATPase/ @entity8 ion/water uptake, making b1-adrenergic activation the only stimulus and its inhibition effective against @entity0 .

title: Inhibition of XXXX after @entity1 -reperfusion by b-adrenergic antagonists: correlation with increased K+ and decreased @entity2 concentrations in extracellular fluid.

answer: @entity0


abstract: UNASSIGNED: In 2012 Alazami et al. described a novel syndromic cause of @entity4 with distinct facial features and severe @entity1 . A homozygous frameshift mutation in @entity5 , a chaperone of the noncoding RNA 7SK, was discovered in @entity0 from a single consanguineous Saudi family. To date, only one additional @entity0 has recently been described. To further delineate the phenotype associated with @entity5 mutations, we report two additional cases originating from the Netherlands and Saudi Arabia. The @entity0 presented with @entity1 , distinct facial features and variable @entity3 . We describe their clinical features and compare them with the previously reported @entity0 . Both cases were identified by diagnostic whole-exome sequencing, which detected two homozygous pathogenic @entity5 variants: @entity6 in the Dutch case and @entity7 in the Saudi Arabian case. Both variants are leading to frameshifts with introduction of premature stop codons, suggesting that loss of function is likely the disease mechanism. This study is an independent @entity2 due to @entity5 depletion. Our cases broaden the associated clinical features of the syndrome and contribute to the delineation of the phenotypic spectrum of @entity5 mutations.Journal of @entity0 Genetics advance online publication, 26 November 2015; doi:10.1038/jhg.2015.134.

title: Broadening the phenotypic spectrum of pathogenic @entity5 variants: two cases with @entity1 , variable XXXX and distinct facial features.

answer: @entity3


abstract: UNASSIGNED: In 2012 Alazami et al. described a novel syndromic cause of @entity4 with distinct facial features and severe @entity1 . A homozygous frameshift mutation in @entity5 , a chaperone of the noncoding RNA 7SK, was discovered in @entity0 from a single consanguineous Saudi family. To date, only one additional @entity0 has recently been described. To further delineate the phenotype associated with @entity5 mutations, we report two additional cases originating from the Netherlands and Saudi Arabia. The @entity0 presented with @entity1 , distinct facial features and variable @entity3 . We describe their clinical features and compare them with the previously reported @entity0 . Both cases were identified by diagnostic whole-exome sequencing, which detected two homozygous pathogenic @entity5 variants: @entity6 in the Dutch case and @entity7 in the Saudi Arabian case. Both variants are leading to frameshifts with introduction of premature stop codons, suggesting that loss of function is likely the disease mechanism. This study is an independent @entity2 due to @entity5 depletion. Our cases broaden the associated clinical features of the syndrome and contribute to the delineation of the phenotypic spectrum of @entity5 mutations.Journal of @entity0 Genetics advance online publication, 26 November 2015; doi:10.1038/jhg.2015.134.

title: Broadening the phenotypic spectrum of pathogenic @entity5 variants: two cases with XXXX , variable @entity3 and distinct facial features.

answer: @entity1


abstract: UNASSIGNED: In 2012 Alazami et al. described a novel syndromic cause of @entity4 with distinct facial features and severe @entity1 . A homozygous frameshift mutation in @entity5 , a chaperone of the noncoding RNA 7SK, was discovered in @entity0 from a single consanguineous Saudi family. To date, only one additional @entity0 has recently been described. To further delineate the phenotype associated with @entity5 mutations, we report two additional cases originating from the Netherlands and Saudi Arabia. The @entity0 presented with @entity1 , distinct facial features and variable @entity3 . We describe their clinical features and compare them with the previously reported @entity0 . Both cases were identified by diagnostic whole-exome sequencing, which detected two homozygous pathogenic @entity5 variants: @entity6 in the Dutch case and @entity7 in the Saudi Arabian case. Both variants are leading to frameshifts with introduction of premature stop codons, suggesting that loss of function is likely the disease mechanism. This study is an independent @entity2 due to @entity5 depletion. Our cases broaden the associated clinical features of the syndrome and contribute to the delineation of the phenotypic spectrum of @entity5 mutations.Journal of @entity0 Genetics advance online publication, 26 November 2015; doi:10.1038/jhg.2015.134.

title: Broadening the phenotypic spectrum of pathogenic XXXX variants: two cases with @entity1 , variable @entity3 and distinct facial features.

answer: @entity5


abstract: This article describes the current status of surgical @entity4 . Combined multimodal treatment including classical @entity3 is still the most recommended and offers excellent survivals. @entity0 suffering from @entity4 as potentially very long-term survivors also need great care of quality of their further life. Nephron-sparing surgery seems an important step in this regard; however, selection of @entity0 is necessary to avoid failures and decreasing survival rate. A new method of describing this kind of procedure developed within the SIOP @entity2 Study Group (RTSG) offers an opportunity for further comparisons and assessment. Minimally invasive nephrectomy is not recommended in the treatment of @entity4 ; however, in experienced hands and correctly selected (rare) cases, minimally invasive nephrectomy may offer the same outcome as the classical open approach. Lymph nodes sampling, essential for reliable @entity1 , appeared rarely correct in @entity0 operated by this technique. Any competition with partial nephrectomy should be avoided in favor of the nephron-sparing approach. A small proportion of @entity0 still create surgical difficulties and this is in fact the target group for further surgical reviews. Their prognosis seems at least in part surgeon-dependent. Few clinical factors available preoperatively ( @entity1 side, age, and @entity1 volume) were detected as influencing potential risk of surgical failures. Once identified, this needs increased attention from the surgical point of view.

title: Current concepts in surgery for XXXX -the risk and function-adapted strategy.

answer: @entity4


abstract: UNASSIGNED: @entity0 progression and physiological changes within the cells are accompanied by alterations in the biophysical properties. Therefore, the cell biophysical properties can serve as promising markers for @entity0 detection and physiological activities. To aid in the investigation of the biophysical markers of cells, a microfluidic chip has been developed which consists of a constriction channel and embedded microelectrodes. Single-cell impedance magnitudes at four frequencies and entry and travel times are measured simultaneously during their transit through the constriction channel. This microchip provides a high-throughput, label-free, automated assay to identify biophysical signatures of malignant cells and monitor the therapeutic efficacy of drugs. Here, we monitored the dynamic cellular biophysical properties in response to @entity1 kinase inhibitors (SphKIs), and compared the effectiveness of drug delivery using @entity2 ( @entity2 ) nanoparticles (NPs) loaded with SphKIs versus conventional delivery. Cells treated with SphKIs showed significantly higher impedance magnitudes at all four frequencies. The bioelectrical parameters extracted using a model also revealed that the highly aggressive breast cells treated with SphKIs shifted electrically towards that of a less malignant phenotype; SphKI-treated cells exhibited an increase in cell-channel interface resistance and a significant decrease in specific membrane capacitance. Furthermore, SphKI-treated cells became slightly more deformable as measured by a decrease in their channel entry and travel times. We observed no significant difference in the bioelectrical changes produced by SphKI delivered conventionally or with NPs. However, NPs-packaged delivery of SphKI decreased the cell deformability. In summary, this study showed that while the bioelectrical properties of the cells were dominantly affected by SphKIs, the biomechanical properties were mainly changed by the NPs.

title: The impact of XXXX kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of @entity0 cells.

answer: @entity1