abstract: INTRODUCTION: @entity2 is the commonest cause of mortality worldwide. Many risk factors predate the development of @entity2 . Adequate knowledge of risk factors for @entity2 is the first step towards effective preventive strategies to combat the @entity2 burden in any population. This study aims to determine the knowledge of workers in a Nigerian University on risk factors for @entity2 . MATERIALS AND METHODS: A cross-sectional survey of 206 academic and non-academic staff of Ladoke Akintola University of Technology, Ogbomoso, Nigeria using the Heart Disease Fact Questionnaire (HDFQ). Demographic data were taken. The lipid profile and random blood sugar were taken. Statistical analysis was done using SPSS 17.0. RESULTS: The mean age of the study @entity0 was 45.3    7.9 years. There were 96 males (46.6%). The mean HDFQ score was 48.6%. Only 41 (19.9%) of @entity0 were assessed to have good knowledge of @entity3 risk factors. Majority, 101 (49.0%) had poor knowledge while 64 (31.2%) had fair knowledge of @entity3 risk factors. There was no significant difference between prevalence of CV risk factors between those with good or fair or low level of knowledge. Most @entity0 did not have a good level of knowledge about risk factors, prevention, treatment and association with @entity1 as it relates to @entity3 . CONCLUSION: Knowledge of @entity3 risk factors is low among University workers in Nigeria. Effective education on @entity3 risk factors and appropriate preventive strategies are indeed important to reduce @entity2 burden in Nigerian University communities.

title: Knowledge of XXXX risk factors among workers in a Nigerian University: A call for concern.

answer: @entity3


abstract: @entity14 , a new anthracycline antibiotic, was used to treat 24 adult @entity0 with @entity10 , using a total dose of 300 mg/m2 (75 mg/m2/day X 4). There were 20 @entity0 with acute myelogenous and four with @entity7 . Approximately two-thirds of the @entity0 had a Karnofsky score of less than or equal to 2, and two-thirds had received two or more previous induction programs. Interim bone marrow evaluation was obtained in 18 of 30 remission induction courses and revealed marked hypocellularity in 14, inadequate specimens in three, and persistent disease in one. Seven @entity0 received more than one course. Two @entity0 refused further therapy. In @entity0 with @entity11 , there were two complete remissions lasting 10 and 16 months and one partial remission lasting 4 1/2 months. There were no responders in @entity0 with @entity7 . @entity2 included profound @entity9 and @entity6 , moderate @entity4 and @entity5 , @entity3 , and @entity1 . There were no cardiac symptoms associated with the drug infusion, but there were three late events possibly associated with @entity13 @entity8 . Used in this dosage schedule, @entity14 is an active, but toxic, agent in the @entity12 .

title: Phase II evaluation of XXXX in refractory adult @entity12 : a Southwest Oncology Group Study.

answer: @entity14


abstract: @entity14 , a new anthracycline antibiotic, was used to treat 24 adult @entity0 with @entity10 , using a total dose of 300 mg/m2 (75 mg/m2/day X 4). There were 20 @entity0 with acute myelogenous and four with @entity7 . Approximately two-thirds of the @entity0 had a Karnofsky score of less than or equal to 2, and two-thirds had received two or more previous induction programs. Interim bone marrow evaluation was obtained in 18 of 30 remission induction courses and revealed marked hypocellularity in 14, inadequate specimens in three, and persistent disease in one. Seven @entity0 received more than one course. Two @entity0 refused further therapy. In @entity0 with @entity11 , there were two complete remissions lasting 10 and 16 months and one partial remission lasting 4 1/2 months. There were no responders in @entity0 with @entity7 . @entity2 included profound @entity9 and @entity6 , moderate @entity4 and @entity5 , @entity3 , and @entity1 . There were no cardiac symptoms associated with the drug infusion, but there were three late events possibly associated with @entity13 @entity8 . Used in this dosage schedule, @entity14 is an active, but toxic, agent in the @entity12 .

title: Phase II evaluation of @entity14 in refractory adult XXXX : a Southwest Oncology Group Study.

answer: @entity12


abstract: UNASSIGNED: We have previously found high incidence of @entity1 ( @entity1 ) in Australia. A population-based registry was established to assess disease severity, frequency of complications and prognostic factors. METHOD: Incident cases were prospectively identified over 4 years. Early disease severity was assessed according to need for hospitalization and resective surgery and medication use. RESULTS: We report on the early outcomes (median 18 months, range 12-60 months) for 252 @entity0 comprising 146 with @entity2 ( @entity2 ), 96 with @entity3 ( @entity3 ) and 10 IBDU ( @entity1 undifferentiated). 87% of @entity2 @entity0 had @entity4 at diagnosis, and this reduced to 73% at 5 years (n=38). Immunomodulators (IM) were prescribed in 57% of @entity2 @entity0 , and 19% with @entity3 . A third of all @entity2 @entity0 were hospitalised, the majority (77%) in the first 12 months. Risk factors for hospitalisation included penetrating, perianal and @entity5 (p<0.05). 24% of @entity3 @entity0 were hospitalized, most within the first 12 months. Intestinal resection rates were 13% at 1 year in @entity2 , and 26% at 5 years. Risk factors include penetrating and stricturing disease (p<0.001), and ileal involvement (p<0.05). Colectomy rates in @entity3 were 2% and 13% at 1 and 5 years. High CRP at diagnosis was associated with colectomy. CONCLUSION: A high rate of @entity4 , frequent IM use in @entity2 and a low rate of surgery in both @entity2 and @entity3 were identified. In @entity2 , ileal involvement and complex disease behaviour are associated with a more severe disease course; while in @entity3 a high CRP predicted this outcome.

title: A Prospective Population Based Cohort of XXXX in the Biologics era - Disease Course and Predictors of Severity.

answer: @entity1


abstract: CONTEXT: Postprandial @entity3 (TG) concentration is independently associated with @entity2 risk. Exercise reduces postprandial TG concentrations, but the mechanisms responsible are unclear. OBJECTIVE: The objective was to determine the effects of exercise on affinity of chylomicrons, large very low-density lipoproteins (VLDL1), and smaller VLDL (VLDL2) for @entity4 ( @entity4 )-mediated TG hydrolysis. DESIGN: This was designed as a within- @entity0 crossover study. SETTING: The setting was a university metabolic investigation unit. @entity0 : @entity0 were 10 overweight/obese @entity0 . INTERVENTIONS: @entity0 undertook two oral fat tolerance tests, separated by 7-14 days, in which they had blood taken while fasting and for 4 hours after a high-fat mixed meal. On the afternoon before one test, they performed a 90-minute treadmill walk at 50% maximal @entity1 uptake (exercise trial [EX]); no exercise was performed before the control trial (CON). MAIN OUTCOME MEASURES: We measured circulating TG-rich lipoprotein concentrations and affinity of chylomicrons, VLDL1, and VLDL2 for @entity4 -mediated TG hydrolysis. RESULTS: Exercise significantly reduced fasting VLDL1-TG concentration (CON, 0.49 [0.33-0.72] mmol.L(-1); EX, 0.36 [0.22-0.59] mmol.L(-1); geometric means [95% confidence interval]; P = .04). Time-averaged postprandial chylomicron-TG (CON, 0.55    0.10 mmol.L(-1); EX, 0.39    0.08 mmol.L(-1); mean    SEM; P = .03) and VLDL1-TG (CON, 0.85    0.13 mmol.L(-1); EX, 0.66    0.10 mmol.L(-1); P = .01) concentrations were both lower in EX than CON. Affinity of VLDL1 for @entity4 -mediated TG hydrolysis increased by 2.2 (1.3-3.7)-fold [geometric mean (95% confidence interval)] (P = .02) in the fasted state and 2.6 (1.8-2.6)-fold (P = .001) postprandially. Affinity of chylomicrons and VLDL2 was not significantly different between trials. CONCLUSIONS: Exercise increases affinity of VLDL1 for @entity4 -mediated TG hydrolysis both fasting and postprandially. This mechanism is likely to contribute to the TG-lowering effect of exercise.

title: Moderate Exercise Increases Affinity of Large Very Low-Density Lipoproteins for Hydrolysis by XXXX .

answer: @entity4


abstract: @entity0 with @entity2 mutations are inundated with decisions about managing @entity1 risks and childbearing considerations. Decisions become more complicated when @entity0 face disclosing their mutation and risk-reduction options to a romantic partner. This study identifies the concerns and perspectives of male romantic partners regarding these unique decisions. Twenty-five male @entity0 completed an online survey posted to @entity1 support group message boards. @entity0 reported relationship changes regarding intimacy levels (n   =   9), attraction (n   =   2), and communication (n   =   22) after mutation disclosure. @entity0 whose partners had not undergone prophylactic mastectomy (n   =   14) reported concerns regarding sexual relations (n   =   5), post-surgical appearance (n   =   2), post-surgical attraction (n   =   5), and health/lifespan (n   =   9). @entity0 did not express attitude changes toward childbearing. While mutation disclosure conversations and surgical options are concerns for many @entity2 mutation carriers in relationships, male partners share these concerns. Aspects of the relationship may change, but male study @entity0 continued to support their partners. This information can benefit female @entity2 mutation carriers, their current or future partners, and genetic counselors working with this particular population.

title: Exploration of Male Attitudes on Partnerships and Sexuality with Female XXXX /2 Mutation Carriers.

answer: @entity2


abstract: UNASSIGNED: An improvement in bond strength to enamel has been demonstrated with the use of @entity1 prior to bonding with self-etch @entity2 -based adhesive agents. No research has evaluated the effect of @entity1 etching of enamel with a newer self-etch @entity4 adhesive. The purpose of this study was to evaluate the shear-bond strength of composite to enamel using the self-etch @entity4 adhesive compared to other self-etching @entity2 -based adhesives, with or without a separate application of @entity1 . @entity0 incisors were sectioned using a @entity3 saw and mounted in plastic pipe. The bonding agents were applied to flattened enamel surfaces with or without the application of 35% @entity1 . The bonded tooth specimens were inserted beneath a mold, and composite was placed incrementally and light cured. The specimens were stored for 24 hours and six months in water and tested in shear. Data were analyzed with a three-way analysis of variance (ANOVA) to evaluate the effects of surface treatment, adhesive agent, or time on the bond strength of composite to @entity0 enamel (a=0.05). Significant differences were found between the groups based on surface treatment (p<0.01) or adhesive agent (p<0.01), but not on time (p=0.19), with no significant interactions (p>0.14). @entity1 etching of @entity0 enamel significantly increased the bond strength of the self-etch @entity2 and the @entity4 adhesives. The @entity2 -based adhesives had significantly greater bond strength to enamel than the @entity4 adhesive.

title: Effect of Selective Etch on the Bond Strength of Composite to Enamel Using a XXXX Adhesive.

answer: @entity4


abstract: PURPOSE: We examined the clinical data of @entity0 treated with @entity3 to determine the risk factors of @entity3 -related @entity2 ( @entity2 ). In addition, we evaluated the efficacy of rechallenging @entity0 with HSRs with @entity3 using prophylactic agents or desensitization procedures. METHODS: This study consisted of 162 @entity0 with @entity1 (88 @entity0 and 74 @entity0 ) who were treated consecutively at the outpatient chemotherapy department at University Hospital, Kyoto Prefectural University of Medicine. @entity0 underwent chemotherapy, including @entity3 , between March 2006 and June 2012. We analyzed the @entity0 ' clinical backgrounds (eg, age, sex, performance status, disease stage, and allergic history) to uncover any connections to the development of @entity2 to @entity3 . In addition, we rechallenged 10 @entity0 who had @entity3 -related @entity2 using prophylactic agents or desensitization procedures. FINDINGS: Of 162 @entity0 , 28 (17.2%) developed @entity3 -related HSRs (16, 2, 9 and 1 @entity0 had grade 1, 2, 3, and 4 HSRs, respectively). The total cumulative dose of @entity3 at the onset of the @entity2 was 301 to 1126 mg/m(2) (median, 582 mg/m(2)), and the first reactions developed in these @entity0 after 5 to 17 infusions of @entity3 (median, 8 infusions). Logistic regression analysis indicated that sex (male: odds ratio = 3.624; 95% CI, 1.181-11.122; P = 0.024) and eosinophil count in peripheral blood (odds ratio = 35.118; 95% CI, 1.058-1166.007; P = 0.046) were independent variables for @entity3 -related HSRs. Rechallenging @entity0 with prophylactic agents was successful in 2 (28.6%) of 7 @entity0 who successfully completed their treatment. On the other hand, all 3 @entity0 rechallenged with @entity3 using a desensitization protocol successfully completed their treatment without new HSRs. IMPLICATIONS: In this retrospective study, we observed that being male and having higher counts of peripheral eosinophil could be predictors for @entity2 to @entity3 . In addition, this study confirms that @entity3 desensitization protocol allows @entity0 who developed HSRs to continue with their treatment. However, the optimum desensitization protocol for @entity3 administration in terms of tolerability and efficacy needs to be defined.

title: XXXX Reactions to @entity3 : Identifying the Risk Factors and Judging the Efficacy of a Desensitization Protocol.

answer: @entity2


abstract: PURPOSE: We examined the clinical data of @entity0 treated with @entity3 to determine the risk factors of @entity3 -related @entity2 ( @entity2 ). In addition, we evaluated the efficacy of rechallenging @entity0 with HSRs with @entity3 using prophylactic agents or desensitization procedures. METHODS: This study consisted of 162 @entity0 with @entity1 (88 @entity0 and 74 @entity0 ) who were treated consecutively at the outpatient chemotherapy department at University Hospital, Kyoto Prefectural University of Medicine. @entity0 underwent chemotherapy, including @entity3 , between March 2006 and June 2012. We analyzed the @entity0 ' clinical backgrounds (eg, age, sex, performance status, disease stage, and allergic history) to uncover any connections to the development of @entity2 to @entity3 . In addition, we rechallenged 10 @entity0 who had @entity3 -related @entity2 using prophylactic agents or desensitization procedures. FINDINGS: Of 162 @entity0 , 28 (17.2%) developed @entity3 -related HSRs (16, 2, 9 and 1 @entity0 had grade 1, 2, 3, and 4 HSRs, respectively). The total cumulative dose of @entity3 at the onset of the @entity2 was 301 to 1126 mg/m(2) (median, 582 mg/m(2)), and the first reactions developed in these @entity0 after 5 to 17 infusions of @entity3 (median, 8 infusions). Logistic regression analysis indicated that sex (male: odds ratio = 3.624; 95% CI, 1.181-11.122; P = 0.024) and eosinophil count in peripheral blood (odds ratio = 35.118; 95% CI, 1.058-1166.007; P = 0.046) were independent variables for @entity3 -related HSRs. Rechallenging @entity0 with prophylactic agents was successful in 2 (28.6%) of 7 @entity0 who successfully completed their treatment. On the other hand, all 3 @entity0 rechallenged with @entity3 using a desensitization protocol successfully completed their treatment without new HSRs. IMPLICATIONS: In this retrospective study, we observed that being male and having higher counts of peripheral eosinophil could be predictors for @entity2 to @entity3 . In addition, this study confirms that @entity3 desensitization protocol allows @entity0 who developed HSRs to continue with their treatment. However, the optimum desensitization protocol for @entity3 administration in terms of tolerability and efficacy needs to be defined.

title: @entity2 Reactions to XXXX : Identifying the Risk Factors and Judging the Efficacy of a Desensitization Protocol.

answer: @entity3


abstract: BACKGROUND: Vitiligo is a common @entity1 that can influence a @entity0 's quality of life. Although @entity0 -orientated medicine is an emerging concept, a self-assessment tool to assess the degree of depigmentation in @entity2 is not yet available. Therefore, we developed the SAVASI, a self-assessment tool that uses the same basic principles as the VASI. OBJECTIVE: To assess the validity, reliability and acceptability of the SAVASI. METHODS: To assess the validity of the SAVASI, we compared the scores assessed by the @entity0 with the scores of the VASI assessed by the physician. To assess the intra-rater reliability, the correlation between the baseline SAVASI and the SAVASI after 2  weeks was calculated. To assess the acceptability, @entity0 indicated the time needed to complete the SAVASI and the @entity0 assessed the difficulty of the questionnaire on a five-point scale. The Skindex-29 was used to determine the quality of life. The overestimation of the SAVASI compared to the VASI was calculated by subtracting the VASI scores off from the SAVASI scores. RESULTS: A high correlation between the VASI and the SAVASI (ICC 0.97, 95% CI: 0.95-0.98) was found in 60 @entity0 . The intra-rater reliability of the SAVASI (ICC 0.75, 95% CI 0.54-0.87) was adequate in 31 @entity0 . Fifty (83%) of the @entity0 completed the questionnaire within 10  min and only five (8%) of the @entity0 considered the SAVASI hard. We found no correlation between overestimation of the SAVASI score and the Skindex-29 score. CONCLUSION: The SAVASI is a valid, reliable and acceptable self-assessment tool to measure the degree of depigmentation in @entity2 . With the SAVASI the degree of depigmentation can reliably be assessed by the @entity0 themselves which can be useful in large (epidemiological) studies. Furthermore, this could contribute to the @entity0 's disease insight and therapy loyalty.

title: The validity, reliability and acceptability of the SAVASI; a new self-assessment score in XXXX .

answer: @entity2


abstract: BACKGROUND: Anesthetic management for cesarean section of @entity0 with @entity4 accreta is challenging. The aim of this retrospective study was to review past @entity4 accreta cases in our hospital to propose a better strategy for anesthetic management for this difficult condition. METHODS: Cases of @entity4 accreta were identified in our anesthesia database. The diagnosis, surgical procedure, amount of @entity1 and anesthetic management were reviewed. RESULTS: Eight cases of @entity4 accreta were identified. Four of the eight cases underwent stepwise treatment, and in one of the four cases, @entity2 ( @entity2 ) was performed. The amount of @entity1 in the four cases ranged from 840 to 1,150 ml. The remaining four cases underwent cesarean hysterectomy. The amount of @entity1 in the four cases ranged from 2,400 to 5,200 ml. Neuraxial anesthesia alone was planned in four cases, but in two of which anesthesia was converted to general anesthesia due to @entity3 . CONCLUSIONS: The present retrospective study showed that stepwise treatment and using @entity2 could be an effective aid for management of plasenta previa accreta. It is necessary to compare the effectiveness of @entity2 with that of common iliac @entity2 in reducing the amount of @entity1 .

title: [Anesthetic management of @entity0 with XXXX accreta for cesarean section: a 7-year single-center experience].

answer: @entity4


abstract: BACKGROUND: Anesthetic management for cesarean section of @entity0 with @entity4 accreta is challenging. The aim of this retrospective study was to review past @entity4 accreta cases in our hospital to propose a better strategy for anesthetic management for this difficult condition. METHODS: Cases of @entity4 accreta were identified in our anesthesia database. The diagnosis, surgical procedure, amount of @entity1 and anesthetic management were reviewed. RESULTS: Eight cases of @entity4 accreta were identified. Four of the eight cases underwent stepwise treatment, and in one of the four cases, @entity2 ( @entity2 ) was performed. The amount of @entity1 in the four cases ranged from 840 to 1,150 ml. The remaining four cases underwent cesarean hysterectomy. The amount of @entity1 in the four cases ranged from 2,400 to 5,200 ml. Neuraxial anesthesia alone was planned in four cases, but in two of which anesthesia was converted to general anesthesia due to @entity3 . CONCLUSIONS: The present retrospective study showed that stepwise treatment and using @entity2 could be an effective aid for management of plasenta previa accreta. It is necessary to compare the effectiveness of @entity2 with that of common iliac @entity2 in reducing the amount of @entity1 .

title: [Anesthetic management of XXXX with @entity4 accreta for cesarean section: a 7-year single-center experience].

answer: @entity0


abstract: When @entity0 polymorphonuclear leukocytes (PMN) are placed on various surfaces, they attach and spread rapidly, increasing their diameter severalfold. The spreading is associated with extensive changes in the cytoskeleton. Since many cytoskeletal events are regulated by @entity1 , we measured the cytosolic free @entity2 concentration ([ @entity1 ]i) in individual @entity0 PMN as they spread. [ @entity1 ]i was measured in single cells by microspectrofluorometry using the fluorescent @entity1 -sensitive dye @entity3 . Immediately before spreading, PMN exhibit a rapid increase in [ @entity1 ]i, from 69 +/- 51 nM to 547 +/- 190 nM (mean +/- SD, n = 12). [ @entity1 ]i returns to near resting levels during the next minute, as the cells spread. Neither the spreading nor the [ @entity1 ]i spike is blocked by removal of extracellular @entity2 , by @entity5 , by calmodulin antagonists, or by mitochondrial or microtubule poisons. Spreading, but not the [ @entity1 ]i increase, is blocked by the microfilament inhibitor cytochalasin B. Both spreading and the [ @entity1 ]i spike are blocked by @entity4 depletion and reversibly blocked by placing the cells in medium containing hypertonic sucrose or @entity6 . These data strongly suggest that an increase in [ @entity1 ]i, derived from nonmitochondrial intracellular pools, plays an important role in the microfilament-mediated process of PMN spreading.

title: Spreading of @entity0 neutrophils is immediately preceded by a large increase in cytoplasmic free XXXX .

answer: @entity2


abstract: When @entity0 polymorphonuclear leukocytes (PMN) are placed on various surfaces, they attach and spread rapidly, increasing their diameter severalfold. The spreading is associated with extensive changes in the cytoskeleton. Since many cytoskeletal events are regulated by @entity1 , we measured the cytosolic free @entity2 concentration ([ @entity1 ]i) in individual @entity0 PMN as they spread. [ @entity1 ]i was measured in single cells by microspectrofluorometry using the fluorescent @entity1 -sensitive dye @entity3 . Immediately before spreading, PMN exhibit a rapid increase in [ @entity1 ]i, from 69 +/- 51 nM to 547 +/- 190 nM (mean +/- SD, n = 12). [ @entity1 ]i returns to near resting levels during the next minute, as the cells spread. Neither the spreading nor the [ @entity1 ]i spike is blocked by removal of extracellular @entity2 , by @entity5 , by calmodulin antagonists, or by mitochondrial or microtubule poisons. Spreading, but not the [ @entity1 ]i increase, is blocked by the microfilament inhibitor cytochalasin B. Both spreading and the [ @entity1 ]i spike are blocked by @entity4 depletion and reversibly blocked by placing the cells in medium containing hypertonic sucrose or @entity6 . These data strongly suggest that an increase in [ @entity1 ]i, derived from nonmitochondrial intracellular pools, plays an important role in the microfilament-mediated process of PMN spreading.

title: Spreading of XXXX neutrophils is immediately preceded by a large increase in cytoplasmic free @entity2 .

answer: @entity0


abstract: A @entity0 presented with a primary @entity2 , Level IV, 2.5 mm thick; 30 excised lymph nodes were all negative for @entity1 . Four local recurrences followed in the ensuing 17 months. @entity1 cells cultured at this time were epithelioid. Autoimmunization was followed by a disease-free interval of 15 months. Postimmunization, the @entity0 's lymphocytes destroyed his @entity2 cells in culture and were stimulated in mixed cell culture by his irradiated @entity1 cells. Cells grown from the relapsing @entity1 were spindle/dendritic with bizarre morphology and were not attacked by his lymphocytes in culture. Using a C' fixation technique, DR antigen profiles of the @entity0 's B-cells and both @entity1 cell types showed that the immunizing @entity1 was positive for DR antigens 3, 5, and 8, none of which were present on his B-cells which had @entity3 . Both B-cells and immunizing @entity1 cells were positive for DQ antigens. The relapsing @entity1 cells were positive for DR2 and negative for all other D region antigens tested. The evidence suggests that given a @entity2 of heterogeneous cell population, autoimmunization against the predominant immunogenic cell inhibits @entity1 growth but allows the ascendance of a nonimmunogenic @entity1 cell type.

title: Immunological heterogeneity in @entity0 XXXX : immunogenic alloantigen expression in autologous host.

answer: @entity2


abstract: A @entity0 presented with a primary @entity2 , Level IV, 2.5 mm thick; 30 excised lymph nodes were all negative for @entity1 . Four local recurrences followed in the ensuing 17 months. @entity1 cells cultured at this time were epithelioid. Autoimmunization was followed by a disease-free interval of 15 months. Postimmunization, the @entity0 's lymphocytes destroyed his @entity2 cells in culture and were stimulated in mixed cell culture by his irradiated @entity1 cells. Cells grown from the relapsing @entity1 were spindle/dendritic with bizarre morphology and were not attacked by his lymphocytes in culture. Using a C' fixation technique, DR antigen profiles of the @entity0 's B-cells and both @entity1 cell types showed that the immunizing @entity1 was positive for DR antigens 3, 5, and 8, none of which were present on his B-cells which had @entity3 . Both B-cells and immunizing @entity1 cells were positive for DQ antigens. The relapsing @entity1 cells were positive for DR2 and negative for all other D region antigens tested. The evidence suggests that given a @entity2 of heterogeneous cell population, autoimmunization against the predominant immunogenic cell inhibits @entity1 growth but allows the ascendance of a nonimmunogenic @entity1 cell type.

title: Immunological heterogeneity in XXXX @entity2 : immunogenic alloantigen expression in autologous host.

answer: @entity0


abstract: BACKGROUND: @entity2 ( @entity2 ) has been associated with an intensive use of health resources and a high economic burden. AIMS OF THE STUDY: The aim of this study is to analyze the use of mental healthcare resources by @entity2 @entity0 , to identify the information gaps on @entity2 at the regional health databases and to describe specific indicators and patterns of care utilization by @entity0 with @entity2 in order to guide evidence-informed policy planning in Catalonia (Spain). METHODS: A multi-level cross-design synthesis approach was applied following a mixed quantitative-qualitative analysis to estimate the regional service utilisation of @entity0 with @entity2 . This framing analysis included estimates based on all available data on the use of services combined with prior expert knowledge gathered through a nominal group of key stakeholders in this field. RESULTS: The estimated year prevalence of @entity2 was 0.7% but only 9.6% of all @entity2 @entity0 in Catalonia had any contact with the health care system. Of those, less than half contacted mental health care. @entity2 represented 1.7% of the total care load in the community mental health centres. A significant information gap was identified in all the official databases and impeded their direct use for planning and resource allocation in @entity2 . Expert knowledge was required to estimate rates of care utilization at every level of care system (primary care, specialized outpatient care and hospital care). Nevertheless the high pattern of care utilization identified at the databases was accurate according to the experts. DISCUSSION: Detection of @entity2 was lower than expected in the local, regional and national databases and registries of Catalonia. Local data was judged highly inaccurate by experts in comparison to data available on other @entity1 in the same databases. IMPLICATIONS FOR HEALTH POLICY AND RESEARCH: Specific incentives should be implemented to improve the availability and accuracy of information on @entity2 at the regional databases. When present, @entity2 should be coded before other @entity1 in clinical records and health databases. Mental health surveys and @entity1 epidemiological studies should specifically incorporate @entity2 in their inclusion criteria and further studies on the utilisation pattern of this disorder are needed, both locally and internationally.

title: Regional Analysis of Health Service Utilisation by XXXX with Borderline Personality Disorders: Implications for Evidence-Informed Policy.

answer: @entity0


abstract: UNASSIGNED: There is still disagreement regarding the intracranial volumes of @entity0 with @entity1 compared with healthy @entity0 . This study aimed to compare the intracranial volume of @entity0 with @entity1 before and after surgery to an age- and sex-matched control cohort using three-dimensional (3D) photogrammetry. Eighteen @entity0 with @entity1 were operated on using standardized fronto-orbital advancement. Frontal, posterior and total intracranial volumes were measured exactly 1 day pre-operatively and 10 days post-operatively, using 3D photogrammetry. To establish an age- and sex-matched control group, the 3D photogrammetric data of 634 healthy @entity0 between the ages of 3 and 13 months were analyzed. Mean age at surgery was 9 months (SD 1.7). Prior to surgery, @entity0 with @entity1 showed significantly reduced frontal and total intracranial volumes compared with the reference group, but similar posterior volumes. After surgery, frontal and total intracranial volumes did not differ statistically from the control group. As @entity0 with @entity1 showed significantly smaller frontal and total intracranial volumes compared with an age- and sex-matched control group, corrective surgery should aim to achieve volume expansion. Furthermore, 3D photogrammetry provides a valuable alternative to CT scans in the measurement of intracranial volume in @entity0 with @entity1 , which significantly reduces the amount of radiation exposure to the growing brain.

title: XXXX : Measuring intracranial volume change following fronto-orbital advancement using three-dimensional photogrammetry.

answer: @entity1


abstract: OBJECTIVE: Low-volume @entity3 ( @entity4 ) bowel preparations have been developed to improve compliance for colonoscopy. Our study aimed to compare the efficacy and tolerability of low-volume @entity4 containing @entity2 for colonoscopy against 2 L of @entity4 plus @entity5 . METHODS: We prospectively enrolled consecutive inpatients who had not undergone polypectomy at the index colonoscopy and were subsequently referred for polypectomy at our hospital. A total of 62 @entity0 were randomized to receive either low-volume @entity4 containing @entity2 (n = 31) or 2 L of @entity4 plus @entity5 (n = 31) as a split-dose regimen in inpatients. The efficacy of preparation was determined using the @entity1 ( @entity1 ) and a 4-point scale. Adverse events, tolerability, and willingness were evaluated using a questionnaire. RESULTS: Based on the @entity1 and 4-point scale, we determined that the efficacy of low-volume @entity4 containing @entity2 was comparable to that of the 2 L of @entity4 plus @entity5 (p = 0.071 for @entity1 , p = 0.056 for the 4-point scale). Adverse events were comparable between the two groups (p = 1.000). A greater proportion of @entity0 in the low-volume @entity4 containing @entity2 (90.6%) and the 2L of @entity4 plus @entity5 (96.9%) were willing to repeat the same preparation for subsequent colonoscopy. CONCLUSION: Low-volume @entity4 containing @entity2 had comparable efficacy and tolerability to 2 L of @entity4 plus @entity5 , when given as a split dose, for colonoscopy in inpatients. Split-dose low-volume @entity4 containing @entity2 is a good alternative for bowel preparation for colonoscopy in inpatients.

title: The use of low-volume @entity3 containing XXXX versus 2 L of @entity3 plus @entity5 as bowel preparation for colonoscopy.

answer: @entity2


abstract: OBJECTIVE: Low-volume @entity3 ( @entity4 ) bowel preparations have been developed to improve compliance for colonoscopy. Our study aimed to compare the efficacy and tolerability of low-volume @entity4 containing @entity2 for colonoscopy against 2 L of @entity4 plus @entity5 . METHODS: We prospectively enrolled consecutive inpatients who had not undergone polypectomy at the index colonoscopy and were subsequently referred for polypectomy at our hospital. A total of 62 @entity0 were randomized to receive either low-volume @entity4 containing @entity2 (n = 31) or 2 L of @entity4 plus @entity5 (n = 31) as a split-dose regimen in inpatients. The efficacy of preparation was determined using the @entity1 ( @entity1 ) and a 4-point scale. Adverse events, tolerability, and willingness were evaluated using a questionnaire. RESULTS: Based on the @entity1 and 4-point scale, we determined that the efficacy of low-volume @entity4 containing @entity2 was comparable to that of the 2 L of @entity4 plus @entity5 (p = 0.071 for @entity1 , p = 0.056 for the 4-point scale). Adverse events were comparable between the two groups (p = 1.000). A greater proportion of @entity0 in the low-volume @entity4 containing @entity2 (90.6%) and the 2L of @entity4 plus @entity5 (96.9%) were willing to repeat the same preparation for subsequent colonoscopy. CONCLUSION: Low-volume @entity4 containing @entity2 had comparable efficacy and tolerability to 2 L of @entity4 plus @entity5 , when given as a split dose, for colonoscopy in inpatients. Split-dose low-volume @entity4 containing @entity2 is a good alternative for bowel preparation for colonoscopy in inpatients.

title: The use of low-volume XXXX containing @entity2 versus 2 L of @entity3 plus @entity5 as bowel preparation for colonoscopy.

answer: @entity3


abstract: OBJECTIVE: Low-volume @entity3 ( @entity4 ) bowel preparations have been developed to improve compliance for colonoscopy. Our study aimed to compare the efficacy and tolerability of low-volume @entity4 containing @entity2 for colonoscopy against 2 L of @entity4 plus @entity5 . METHODS: We prospectively enrolled consecutive inpatients who had not undergone polypectomy at the index colonoscopy and were subsequently referred for polypectomy at our hospital. A total of 62 @entity0 were randomized to receive either low-volume @entity4 containing @entity2 (n = 31) or 2 L of @entity4 plus @entity5 (n = 31) as a split-dose regimen in inpatients. The efficacy of preparation was determined using the @entity1 ( @entity1 ) and a 4-point scale. Adverse events, tolerability, and willingness were evaluated using a questionnaire. RESULTS: Based on the @entity1 and 4-point scale, we determined that the efficacy of low-volume @entity4 containing @entity2 was comparable to that of the 2 L of @entity4 plus @entity5 (p = 0.071 for @entity1 , p = 0.056 for the 4-point scale). Adverse events were comparable between the two groups (p = 1.000). A greater proportion of @entity0 in the low-volume @entity4 containing @entity2 (90.6%) and the 2L of @entity4 plus @entity5 (96.9%) were willing to repeat the same preparation for subsequent colonoscopy. CONCLUSION: Low-volume @entity4 containing @entity2 had comparable efficacy and tolerability to 2 L of @entity4 plus @entity5 , when given as a split dose, for colonoscopy in inpatients. Split-dose low-volume @entity4 containing @entity2 is a good alternative for bowel preparation for colonoscopy in inpatients.

title: The use of low-volume @entity3 containing @entity2 versus 2 L of XXXX plus @entity5 as bowel preparation for colonoscopy.

answer: @entity3


abstract: OBJECTIVE: Low-volume @entity3 ( @entity4 ) bowel preparations have been developed to improve compliance for colonoscopy. Our study aimed to compare the efficacy and tolerability of low-volume @entity4 containing @entity2 for colonoscopy against 2 L of @entity4 plus @entity5 . METHODS: We prospectively enrolled consecutive inpatients who had not undergone polypectomy at the index colonoscopy and were subsequently referred for polypectomy at our hospital. A total of 62 @entity0 were randomized to receive either low-volume @entity4 containing @entity2 (n = 31) or 2 L of @entity4 plus @entity5 (n = 31) as a split-dose regimen in inpatients. The efficacy of preparation was determined using the @entity1 ( @entity1 ) and a 4-point scale. Adverse events, tolerability, and willingness were evaluated using a questionnaire. RESULTS: Based on the @entity1 and 4-point scale, we determined that the efficacy of low-volume @entity4 containing @entity2 was comparable to that of the 2 L of @entity4 plus @entity5 (p = 0.071 for @entity1 , p = 0.056 for the 4-point scale). Adverse events were comparable between the two groups (p = 1.000). A greater proportion of @entity0 in the low-volume @entity4 containing @entity2 (90.6%) and the 2L of @entity4 plus @entity5 (96.9%) were willing to repeat the same preparation for subsequent colonoscopy. CONCLUSION: Low-volume @entity4 containing @entity2 had comparable efficacy and tolerability to 2 L of @entity4 plus @entity5 , when given as a split dose, for colonoscopy in inpatients. Split-dose low-volume @entity4 containing @entity2 is a good alternative for bowel preparation for colonoscopy in inpatients.

title: The use of low-volume @entity3 containing @entity2 versus 2 L of @entity3 plus XXXX as bowel preparation for colonoscopy.

answer: @entity5


abstract: OBJECTIVE: This is the first cohort in which @entity1 and @entity5 in @entity10 are described extensively. METHODS: Retrospective analysis of the otorhinolaryngological and clinical genetic data from 97 @entity10 ( @entity10 ) @entity0 . Forty-four @entity10 @entity0 were seen by an otorhinolaryngologist for the analysis of @entity1 . In our cohort 80 of the 97 @entity0 were genetically tested. In 71 of these mutations were found: in 48 @entity0 a mutation in @entity8 , in 10 @entity0 in @entity12 , in 5 @entity0 in @entity11 , in 5 @entity0 in @entity9 , in 1 @entity0 in @entity13 , in 1 @entity0 in @entity3 and in 1 @entity0 in @entity14 . RESULTS: @entity5 were reported in 75 @entity10 @entity0 (77%). In 69 @entity0 the ears were low-set, 28 @entity0 had @entity2 , 14 @entity0 showed protruding ears and 18 had thickened helices. Hearing impairment was detected in 34 @entity10 @entity0 . Nine @entity0 had @entity4 , two a permanent conductive @entity1 , two other @entity0 had mixed @entity1 and 20 @entity0 had conductive @entity1 in the past, caused by @entity7 media with effusion. Their temporary conductive @entity1 resolved between the ages of 2 and 18 years. @entity4 varied between mild @entity6 and profound (uni- and bilateral) @entity1 and was progressive in three @entity0 . Four @entity10 @entity0 received cochlear implants for their severe @entity4 . The cohort is small for genotype-phenotype correlations, but @entity4 , especially the bilateral severe @entity1 , was only seen in @entity0 with a @entity8 mutation. CONCLUSION: @entity10 is characterized by dysmorphic @entity5 and both @entity4 . Audiological examinations are recommended in all @entity0 with @entity10 .

title: @entity5 and XXXX in @entity10 .

answer: @entity1


abstract: OBJECTIVE: This is the first cohort in which @entity1 and @entity5 in @entity10 are described extensively. METHODS: Retrospective analysis of the otorhinolaryngological and clinical genetic data from 97 @entity10 ( @entity10 ) @entity0 . Forty-four @entity10 @entity0 were seen by an otorhinolaryngologist for the analysis of @entity1 . In our cohort 80 of the 97 @entity0 were genetically tested. In 71 of these mutations were found: in 48 @entity0 a mutation in @entity8 , in 10 @entity0 in @entity12 , in 5 @entity0 in @entity11 , in 5 @entity0 in @entity9 , in 1 @entity0 in @entity13 , in 1 @entity0 in @entity3 and in 1 @entity0 in @entity14 . RESULTS: @entity5 were reported in 75 @entity10 @entity0 (77%). In 69 @entity0 the ears were low-set, 28 @entity0 had @entity2 , 14 @entity0 showed protruding ears and 18 had thickened helices. Hearing impairment was detected in 34 @entity10 @entity0 . Nine @entity0 had @entity4 , two a permanent conductive @entity1 , two other @entity0 had mixed @entity1 and 20 @entity0 had conductive @entity1 in the past, caused by @entity7 media with effusion. Their temporary conductive @entity1 resolved between the ages of 2 and 18 years. @entity4 varied between mild @entity6 and profound (uni- and bilateral) @entity1 and was progressive in three @entity0 . Four @entity10 @entity0 received cochlear implants for their severe @entity4 . The cohort is small for genotype-phenotype correlations, but @entity4 , especially the bilateral severe @entity1 , was only seen in @entity0 with a @entity8 mutation. CONCLUSION: @entity10 is characterized by dysmorphic @entity5 and both @entity4 . Audiological examinations are recommended in all @entity0 with @entity10 .

title: @entity5 and @entity1 in XXXX .

answer: @entity10


abstract: OBJECTIVE: This is the first cohort in which @entity1 and @entity5 in @entity10 are described extensively. METHODS: Retrospective analysis of the otorhinolaryngological and clinical genetic data from 97 @entity10 ( @entity10 ) @entity0 . Forty-four @entity10 @entity0 were seen by an otorhinolaryngologist for the analysis of @entity1 . In our cohort 80 of the 97 @entity0 were genetically tested. In 71 of these mutations were found: in 48 @entity0 a mutation in @entity8 , in 10 @entity0 in @entity12 , in 5 @entity0 in @entity11 , in 5 @entity0 in @entity9 , in 1 @entity0 in @entity13 , in 1 @entity0 in @entity3 and in 1 @entity0 in @entity14 . RESULTS: @entity5 were reported in 75 @entity10 @entity0 (77%). In 69 @entity0 the ears were low-set, 28 @entity0 had @entity2 , 14 @entity0 showed protruding ears and 18 had thickened helices. Hearing impairment was detected in 34 @entity10 @entity0 . Nine @entity0 had @entity4 , two a permanent conductive @entity1 , two other @entity0 had mixed @entity1 and 20 @entity0 had conductive @entity1 in the past, caused by @entity7 media with effusion. Their temporary conductive @entity1 resolved between the ages of 2 and 18 years. @entity4 varied between mild @entity6 and profound (uni- and bilateral) @entity1 and was progressive in three @entity0 . Four @entity10 @entity0 received cochlear implants for their severe @entity4 . The cohort is small for genotype-phenotype correlations, but @entity4 , especially the bilateral severe @entity1 , was only seen in @entity0 with a @entity8 mutation. CONCLUSION: @entity10 is characterized by dysmorphic @entity5 and both @entity4 . Audiological examinations are recommended in all @entity0 with @entity10 .

title: XXXX and @entity1 in @entity10 .

answer: @entity5


abstract: OBJECTIVES: The aim was to test whether or not the marginal bone-level alterations of loaded zirconia implants are similar to the bone-level alterations of a grade 4 @entity3 one-piece dental implant. MATERIALS AND METHODS: In six @entity1 , all premolars and the first molars were extracted in the mandible. Four months later, three zirconia implants ( @entity4 , VC, ZD) and a control @entity3 one-piece (STM) implant were randomly placed in each hemimandible and left for transmucosal healing (baseline). Six months later, CAD/CAM crowns were cemented. Sacrifice was scheduled at 6-month postloading. Digital X-rays were taken at implant placement, crowns insertion, and sacrifice. Marginal bone-level alterations were calculated, and intra- and intergroup comparisons performed adjusted by confounding factors. RESULTS: Implants were successfully placed. Until crown insertion, two implants were @entity0 (one VC, one ZD). At sacrifice, 5 more implants were (partly) @entity0 (one @entity4 , four ZD), and one lost osseointegration (VC). No decementation of crowns occurred. All implant systems demonstrated a statistically significant (except VC) loss of marginal bone between baseline and crown insertion ranging from 0.29  mm (VC; P  =  0.116) to 0.80  mm (ZD; P  =  0.013). The estimated marginal @entity2 between baseline and 6  months of loading ranged between 0.19  mm ( @entity4 ) and 1.11  mm (VC), being statistically significant for STM and VC only (P  <  0.05). The changes in marginal bone levels were statistically significantly different between zirconia implants and control implants (STM vs. @entity4 P  =  0.007; vs. VC P  =  0.001; vs. ZD P  =  0.011). CONCLUSIONS: Zirconia implants were more prone to @entity0 prior to and after loading with implant-supported crowns compared to @entity3 implants. Individual differences and variability in the extent of the bone-level changes during the 12-month study period were found between the different implant types and materials.

title: Marginal bone-level alterations of loaded zirconia and XXXX dental implants: an experimental study in the @entity1 mandible.

answer: @entity3


abstract: OBJECTIVES: The aim was to test whether or not the marginal bone-level alterations of loaded zirconia implants are similar to the bone-level alterations of a grade 4 @entity3 one-piece dental implant. MATERIALS AND METHODS: In six @entity1 , all premolars and the first molars were extracted in the mandible. Four months later, three zirconia implants ( @entity4 , VC, ZD) and a control @entity3 one-piece (STM) implant were randomly placed in each hemimandible and left for transmucosal healing (baseline). Six months later, CAD/CAM crowns were cemented. Sacrifice was scheduled at 6-month postloading. Digital X-rays were taken at implant placement, crowns insertion, and sacrifice. Marginal bone-level alterations were calculated, and intra- and intergroup comparisons performed adjusted by confounding factors. RESULTS: Implants were successfully placed. Until crown insertion, two implants were @entity0 (one VC, one ZD). At sacrifice, 5 more implants were (partly) @entity0 (one @entity4 , four ZD), and one lost osseointegration (VC). No decementation of crowns occurred. All implant systems demonstrated a statistically significant (except VC) loss of marginal bone between baseline and crown insertion ranging from 0.29  mm (VC; P  =  0.116) to 0.80  mm (ZD; P  =  0.013). The estimated marginal @entity2 between baseline and 6  months of loading ranged between 0.19  mm ( @entity4 ) and 1.11  mm (VC), being statistically significant for STM and VC only (P  <  0.05). The changes in marginal bone levels were statistically significantly different between zirconia implants and control implants (STM vs. @entity4 P  =  0.007; vs. VC P  =  0.001; vs. ZD P  =  0.011). CONCLUSIONS: Zirconia implants were more prone to @entity0 prior to and after loading with implant-supported crowns compared to @entity3 implants. Individual differences and variability in the extent of the bone-level changes during the 12-month study period were found between the different implant types and materials.

title: Marginal bone-level alterations of loaded zirconia and @entity3 dental implants: an experimental study in the XXXX mandible.

answer: @entity1


abstract: UNASSIGNED: Dialectical behaviour therapy (DBT)-informed skills training for @entity1 ( @entity1 ) aims at the development of specific emotion regulation skills in @entity0 , particularly with regard to the regulation of problematic anger. While the effects of dialectical behaviour skills training have been shown, their processes of change are rarely examined. Neacsiu, Rizvi and Linehan (2010) found that @entity0 's self-reported use of emotion regulation skills was a mediator of therapeutic change in these treatments; however, they found no effect for problematic anger. From an integrative perspective on anger (Pascual-Leone _ Greenberg, 2007; Pascual-Leone _ Paivio, 2013), there are several forms of anger, varying in their degree of therapeutic productivity. The present add-on randomized controlled trial included n   =   41 @entity0 with @entity1 (n   =   21 DBT-informed skills training versus n   =   20 treatment as usual). The first study examined the outcome of the DBT-informed skills training encompassing basic components of training in mindfulness, distress tolerance, interpersonal effectiveness and emotion regulation. Results showed that symptom reduction was significantly greater in the DBT-informed skills training, compared with the treatment as usual. The second study used process assessment, for which all @entity0 completers underwent a 50-min-long psychological interview both early and late in treatment, which was rated using the Classification of Affective Meaning States. DBT-informed skills training produced increased levels of primary 'assertive' anger, as compared with the treatment as usual, whereas no effect was found for 'rejecting' secondary anger. Most importantly, we showed that changes in assertive anger mediated the reported symptom reduction, in particular in @entity0 's social roles. We discuss these results in the context of underlying mechanisms of change in DBT skills group treatments, in particular towards developing more productive forms of anger in this @entity0 population. Copyright    2015 John Wiley _ Sons, Ltd. KEY PRACTITIONER MESSAGE: A 20-session dialectical behaviour therapy (DBT)-informed skills training is a promising adjunct intervention for @entity0 with @entity1 , in particular for reducing problems related to social role. Increases in assertive anger mediate the effects of DBT-informed skills training, whereas rejecting anger remains unchanged over the course of treatment. Short-term objectives for intervention might involve the specific increase of assertive anger in @entity1 , by using DBT-informed skills training; long-term objectives for intervention might involve a specific decrease of rejecting anger in @entity1 .

title: Assertive Anger Mediates Effects of Dialectical Behaviour-informed Skills Training for XXXX : A Randomized Controlled Trial.

answer: @entity1


abstract: The extent of early resolution of major @entity3 observed in 10 @entity0 after 24 hours of treatment with heparin was compared with that seen in 17 @entity0 after 24 hours of treatment with streptokinase. The @entity0 in the streptokinase group also received a loading dose of heparin and were treated with heparin by continuous infusion when their @entity2 time returned to normal levels. All had @entity1 . @entity3 was classified as acute in the 10 @entity0 in the heparin group. Seven of these @entity0 showed no angiographic change, two showed slight improvement and one showed @entity4 . There was a moderate and statistically insignificant fall in mean pulmonary arterial pressure and total pulmonary resistance. Fourteen of the 17 @entity0 who were studied before and after streptokinase were classified as acute and three as subacute progressive major @entity3 . Eight showed marked angiographic improvement, four moderate and two slight angiographic improvement. There was a moderate and statistically significant fall in the mean pulmonary arterial pressure and pulmonary vascular resistance. In addition, all seven @entity0 in whom no angiographic improvement occurred during heparin therapy showed moderate or marked angiographic improvement after a further 24 hours of treatment with streptokinase. The results strongly suggest that streptokinase therapy accelerates thrombolysis in @entity0 with acute major @entity3 .

title: Comparison of the effects of streptokinase and heparin on the early rate of resolution of major XXXX .

answer: @entity3


abstract: The Wolfram, or @entity9 , syndrome consists of @entity5 , @entity1 , @entity4 , and @entity7 . @entity1 usually occurs as the first manifestation of this syndrome, followed by the development of @entity4 , @entity2 , and finally @entity5 . We report on four cases with a review of the literature. The @entity1 occurring in these @entity0 is clinically indistinguishable from classic @entity1 . Two of three @entity0 continue to have measurable C-peptide secretion 8 yr after onset of @entity1 . Two of three @entity0 with @entity9 had the HLA-DR2 antigen. Combining our cases with those described in the literature, 7 of 11 @entity0 have the HLA-DR2 antigen. The preponderance of the HLA-DR2 antigen in the @entity9 is different from classic @entity3 . This is further evidence of the genetic heterogeneity of @entity1 . Although the @entity9 is rare, it should be considered in @entity1 @entity0 with unexplained @entity4 and @entity2 or with @entity6 and @entity8 in the presence of adequate blood sugar control.

title: XXXX : report of four new cases and a review of literature.

answer: @entity9


abstract: UNASSIGNED: MicroRNA 26a ( @entity7 ) has been reported to play functions in cellular differentiation, cell growth, cell apoptosis and @entity0 . However, the role of @entity7 in transplant rejection has never been investigated. Full-thickness skin grafts 1 to 2 cm in diameter were obtained from the tail-skin CBA/J donor @entity1 and transplanted onto the back of wild-type C57BL/6 recipient @entity1 . Vectors encoding pre- @entity7 (LV-26a) and an empty lentiviral vector (LV-Con) delivered approximately 2 * 10(7) transforming units of recombinant lentivirus were injected to @entity1 once through the tail vein. @entity7 overexpression results in prolonged skin allograft survival (MST = 9.5 days in LV-Con @entity1 ; MST = 22 days in LV-26a @entity1 . P < 0.01) and promoted regulatory T cells (Tregs) expansion. The prolonged skin allograft survival induced by LV-26a was abrogated by depletion of Tregs with anti- @entity6 antibodies. @entity7 significantly promoted @entity4 expression and suppressed the expression of @entity3 , @entity2 and IFN-y. Furthermore, @entity3 overexpression led to complete suppression of the @entity7 -induced upregulation of @entity5 . The prolonged allograft survival induced by LV- @entity7 was also completely abrogated by @entity3 overexpression. In conclusion, @entity7 prolongs skin allograft survival and promotes Tregs expansion in part through inhibition of @entity3 expression. This article is protected by copyright. All rights reserved.

title: MicroRNA 26a Prolongs Skin Allograft Survival and Promotes Regulatory T Cells Expansion in XXXX .

answer: @entity1


abstract: BACKGROUND: @entity2 is known as a risk factor for the development of the @entity3 (post-infectious @entity3 , @entity5 ). The incidence of @entity5 ranges between 3% and over 30% of @entity0 after @entity4 . AIM: To perform a meta-analysis pools and report data concerning the relative risk (RR) of @entity5 after @entity6 . METHODS: Database search using Medline through PubMed, Scopus, EBM Reviews (Cochrane Database of Systematic Reviews) and PsycINFO was performed to identify relevant studies. Those that met the inclusion criteria were pooled. A random effects model (Mantel-Haenszel) was performed. RESULTS: Six eligible studies were found. In three of six studies, the authors reported a statistically significant association of @entity6 and @entity5 . The pooled RR was 3.35 (95% CI: 2.22-5.05) with a significant overall effect (P  <  0.00001). Overall @entity5 incidence was 5.4% in @entity6 subjects and 1.4% in healthy subjects. There was no significant heterogeneity within the pooled studies (I(2)   =  5%). Self-reported @entity6 alone resulted in an over 1.5-fold RR for @entity5 compared to laboratory-confirmed @entity6 [RR 3.90 (95% CI: 2.35-6.49) vs. RR 2.42 (95% CI: 1.22-4.78)]. CONCLUSIONS: There is a strong association between travellers' @entity1 and post-infectious @entity3 . Self-reports of exposure seem to result in a higher post-infectious @entity3 occurrence than laboratory-confirmed cases of travellers' @entity1 , but further studies are needed to confirm this finding. Finally, potential influences of the selection of an appropriate study population on post-infectious @entity3 epidemiology are discussed.

title: Systematic review with meta-analysis: post-infectious @entity3 after travellers' XXXX .

answer: @entity1


abstract: BACKGROUND: @entity2 is known as a risk factor for the development of the @entity3 (post-infectious @entity3 , @entity5 ). The incidence of @entity5 ranges between 3% and over 30% of @entity0 after @entity4 . AIM: To perform a meta-analysis pools and report data concerning the relative risk (RR) of @entity5 after @entity6 . METHODS: Database search using Medline through PubMed, Scopus, EBM Reviews (Cochrane Database of Systematic Reviews) and PsycINFO was performed to identify relevant studies. Those that met the inclusion criteria were pooled. A random effects model (Mantel-Haenszel) was performed. RESULTS: Six eligible studies were found. In three of six studies, the authors reported a statistically significant association of @entity6 and @entity5 . The pooled RR was 3.35 (95% CI: 2.22-5.05) with a significant overall effect (P  <  0.00001). Overall @entity5 incidence was 5.4% in @entity6 subjects and 1.4% in healthy subjects. There was no significant heterogeneity within the pooled studies (I(2)   =  5%). Self-reported @entity6 alone resulted in an over 1.5-fold RR for @entity5 compared to laboratory-confirmed @entity6 [RR 3.90 (95% CI: 2.35-6.49) vs. RR 2.42 (95% CI: 1.22-4.78)]. CONCLUSIONS: There is a strong association between travellers' @entity1 and post-infectious @entity3 . Self-reports of exposure seem to result in a higher post-infectious @entity3 occurrence than laboratory-confirmed cases of travellers' @entity1 , but further studies are needed to confirm this finding. Finally, potential influences of the selection of an appropriate study population on post-infectious @entity3 epidemiology are discussed.

title: Systematic review with meta-analysis: post-infectious XXXX after travellers' @entity1 .

answer: @entity3


abstract: BACKGROUND: The release of cardiac biomarkers of @entity1 after transcatheter aortic valve replacement (TAVR) is common, but no data exist on @entity0 undergoing TAVR through a transaortic approach. We aimed to evaluate the incidence and prognostic significance of the increase in cardiac biomarkers in nontransfemoral TAVR candidates, comparing transaortic and transapical approaches. METHODS: After excluding @entity0 deemed suitable for transfemoral TAVR, 251 consecutive @entity0 (transaortic, 45; transapical, 206) were prospectively evaluated. @entity2 kinase-myocardial band and cardiac troponin T levels were measured at baseline and at 6, 12, 24, 48, and 72 hours after TAVR. Baseline and 6- to 12-month echocardiographic and clinical follow-up were performed. RESULTS: After TAVR, cardiac troponin T increased above the upper normal values in all @entity0 (peak value 0.64  g/L [IQR, 0.39 to 1.03  g/L]), whereas @entity2 kinase-myocardial band levels increased in 88% of @entity0 (transaortic 51%, transapical 96%, p < 0.001; peak value 20.1   g/L [interquartile range, 14.3 to 31.6  g/L]). Compared with the transaortic approach, the transapical approach was associated with a greater rise in both cardiac biomarkers (p < 0.001 for both), and a lesser improvement in left ventricular ejection fraction (p  = 0.058) and @entity3 (p  = 0.039) at 6- to 12-month follow-up. Greater increases of cardiac troponin T levels were independently associated with 30-day and 1-year overall and cardiovascular mortality (p < 0.001 for all). A 15-fold rise in cardiac troponin T levels was the optimal threshold for determining poorer outcomes (p < 0.001). CONCLUSIONS: Periprocedural TAVR-related @entity1 in nontransfemoral candidates was demonstrated in all @entity0 , but the transapical approach was associated with significantly greater @entity1 compared with the transaortic approach. A higher degree of @entity1 translated into reduced left ventricular function improvement and lower early and midterm survival rates.

title: XXXX After Transaortic Versus  Transapical Transcatheter Aortic Valve  Replacement.

answer: @entity1


abstract: PURPOSE: The purpose of this study was to evaluate the risks of second @entity3 and @entity4 associated with an optimized volumetric modulated arc therapy (VMAT) planning solution in a selected cohort of stage I/II @entity8 ( @entity8 ) @entity1 treated with either involved-node or involved-site radiation therapy in comparison with 3-dimensional conformal radiation therapy (3D-CRT). METHODS AND MATERIALS: Thirty-eight @entity1 (13 males and 25 females) were included. Disease extent was mediastinum alone (n=8, 21.1%); mediastinum plus unilateral neck (n=19, 50%); mediastinum plus bilateral neck (n=11, 29.9%). Prescription dose was 30 Gy in 2-Gy fractions. Only 5 @entity1 had mediastinal bulky disease at diagnosis (13.1%). Anteroposterior 3D-CRT was compared with a multiarc optimized VMAT solution. Lung, breast, and @entity5 risks were estimated by calculating a lifetime attributable risk (LAR), with a LAR ratio (LARVMAT-to-LAR3D-CRT) as a comparative measure. @entity9 risks were estimated by calculating absolute excess risk (AER). RESULTS: The LAR ratio favored 3D-CRT for @entity2 induction risk in mediastinal alone (P=.004) and mediastinal plus unilateral neck (P=.02) presentations. LAR ratio for @entity0 was lower for VMAT in mediastinal plus bilateral neck presentations (P=.02), without differences for other sites. For @entity5 , no significant differences were observed, regardless of anatomical presentation. A significantly lower AER of cardiac (P=.038) and @entity7 (P<.0001) was observed for VMAT regardless of disease extent. CONCLUSIONS: In a cohort of @entity1 with favorable characteristics in terms of disease extent at diagnosis (large prevalence of nonbulky presentations without axillary involvement), optimized VMAT reduced @entity6 risk with comparable risks of @entity0 , with an increase in @entity2 induction probability. The results are however strongly influenced by the different anatomical presentations, supporting an individualized approach.

title: Optimized Volumetric Modulated Arc Therapy Versus 3D-CRT for Early Stage Mediastinal XXXX Without Axillary Involvement: A @entity3 and @entity6 Risk.

answer: @entity8


abstract: PURPOSE: The purpose of this study was to evaluate the risks of second @entity3 and @entity4 associated with an optimized volumetric modulated arc therapy (VMAT) planning solution in a selected cohort of stage I/II @entity8 ( @entity8 ) @entity1 treated with either involved-node or involved-site radiation therapy in comparison with 3-dimensional conformal radiation therapy (3D-CRT). METHODS AND MATERIALS: Thirty-eight @entity1 (13 males and 25 females) were included. Disease extent was mediastinum alone (n=8, 21.1%); mediastinum plus unilateral neck (n=19, 50%); mediastinum plus bilateral neck (n=11, 29.9%). Prescription dose was 30 Gy in 2-Gy fractions. Only 5 @entity1 had mediastinal bulky disease at diagnosis (13.1%). Anteroposterior 3D-CRT was compared with a multiarc optimized VMAT solution. Lung, breast, and @entity5 risks were estimated by calculating a lifetime attributable risk (LAR), with a LAR ratio (LARVMAT-to-LAR3D-CRT) as a comparative measure. @entity9 risks were estimated by calculating absolute excess risk (AER). RESULTS: The LAR ratio favored 3D-CRT for @entity2 induction risk in mediastinal alone (P=.004) and mediastinal plus unilateral neck (P=.02) presentations. LAR ratio for @entity0 was lower for VMAT in mediastinal plus bilateral neck presentations (P=.02), without differences for other sites. For @entity5 , no significant differences were observed, regardless of anatomical presentation. A significantly lower AER of cardiac (P=.038) and @entity7 (P<.0001) was observed for VMAT regardless of disease extent. CONCLUSIONS: In a cohort of @entity1 with favorable characteristics in terms of disease extent at diagnosis (large prevalence of nonbulky presentations without axillary involvement), optimized VMAT reduced @entity6 risk with comparable risks of @entity0 , with an increase in @entity2 induction probability. The results are however strongly influenced by the different anatomical presentations, supporting an individualized approach.

title: Optimized Volumetric Modulated Arc Therapy Versus 3D-CRT for Early Stage Mediastinal @entity8 Without Axillary Involvement: A @entity3 and XXXX Risk.

answer: @entity6


abstract: PURPOSE: The purpose of this study was to evaluate the risks of second @entity3 and @entity4 associated with an optimized volumetric modulated arc therapy (VMAT) planning solution in a selected cohort of stage I/II @entity8 ( @entity8 ) @entity1 treated with either involved-node or involved-site radiation therapy in comparison with 3-dimensional conformal radiation therapy (3D-CRT). METHODS AND MATERIALS: Thirty-eight @entity1 (13 males and 25 females) were included. Disease extent was mediastinum alone (n=8, 21.1%); mediastinum plus unilateral neck (n=19, 50%); mediastinum plus bilateral neck (n=11, 29.9%). Prescription dose was 30 Gy in 2-Gy fractions. Only 5 @entity1 had mediastinal bulky disease at diagnosis (13.1%). Anteroposterior 3D-CRT was compared with a multiarc optimized VMAT solution. Lung, breast, and @entity5 risks were estimated by calculating a lifetime attributable risk (LAR), with a LAR ratio (LARVMAT-to-LAR3D-CRT) as a comparative measure. @entity9 risks were estimated by calculating absolute excess risk (AER). RESULTS: The LAR ratio favored 3D-CRT for @entity2 induction risk in mediastinal alone (P=.004) and mediastinal plus unilateral neck (P=.02) presentations. LAR ratio for @entity0 was lower for VMAT in mediastinal plus bilateral neck presentations (P=.02), without differences for other sites. For @entity5 , no significant differences were observed, regardless of anatomical presentation. A significantly lower AER of cardiac (P=.038) and @entity7 (P<.0001) was observed for VMAT regardless of disease extent. CONCLUSIONS: In a cohort of @entity1 with favorable characteristics in terms of disease extent at diagnosis (large prevalence of nonbulky presentations without axillary involvement), optimized VMAT reduced @entity6 risk with comparable risks of @entity0 , with an increase in @entity2 induction probability. The results are however strongly influenced by the different anatomical presentations, supporting an individualized approach.

title: Optimized Volumetric Modulated Arc Therapy Versus 3D-CRT for Early Stage Mediastinal @entity8 Without Axillary Involvement: A XXXX and @entity6 Risk.

answer: @entity3


abstract: @entity3 results in a reduction in cardiac baroreflex sensitivity and a shift in the baroreflex working range to higher heart rates. This effect is mediated, in part, by the carotid chemoreceptors. Therefore, we hypothesized @entity3 -mediated changes in baroreflex control of heart rate would be blunted in carotid body-resected @entity0 when compared with healthy controls. Five @entity0 with bilateral carotid body resection for @entity1 and 10 healthy controls completed a 180-minute @entity2 , hypoglycemic (   3.3 mmol/L) clamp. Changes in heart rate, blood pressure, and spontaneous cardiac baroreflex sensitivity were assessed. Baseline baroreflex sensitivity was not different between groups (P>0.05). @entity3 resulted in a reduction in baroreflex sensitivity in both the groups (main effect of time, P<0.01) and responses were lower in resected @entity0 when compared with controls (main effect of group, P<0.05). @entity3 resulted in large reductions in systolic (-17  7 mm Hg) and mean (-14  5 mm Hg) blood pressure in resected @entity0 that were not observed in controls (interaction of group and time, P<0.05). Despite lower blood pressures, increases in heart rate with @entity3 were blunted in resected @entity0 (interaction of group and time, P<0.01). Major novel findings from this study demonstrate that intact carotid chemoreceptors are essential for increasing heart rate and maintaining arterial blood pressure during @entity3 in @entity0 . These data support a contribution of the carotid chemoreceptors to blood pressure control and highlight the potential widespread effects of carotid body resection in @entity0 .

title: Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during XXXX .

answer: @entity3


abstract: Purpose: To evaluate ultrasonographic accuracy in the differentiation of a bezoar from feces in a @entity1 showing feces-like material just proximal to the transitional zone in abdominal computed tomography (CT). Methods: This study included 14 @entity0 who showed feces-like material just proximal to the transitional zone, among 302 @entity0 diagnosed with @entity1 on abdominal CT. Ultrasonographic findings such as posterior acoustic shadow and twinkling artifact were considered the diagnostic signs of a bezoar. The diagnostic performance was assessed by comparing these with a clinical diagnosis, which was confirmed by surgery or symptomatic improvement. Results: Among the 14 @entity0 , seven were ultrasonographically diagnosed as having a bezoar, and five of them were surgically diagnosed as having a phytobezoar. Two @entity0 diagnosed as having a bezoar showed complete symptomatic improvement before surgery. The seven @entity0 for whom having a bezoar was ruled out ultrasonographically conservatively treated. Among them, six @entity0 showed symptomatic improvement, suggesting the absence of a bezoar. The seventh @entity0 was confirmed as adhesive band-induced @entity2 . In all @entity0 , the ultrasonographic diagnosis agreed with the clinically confirmed diagnosis. Conclusion: Ultrasonography is an accurate method for the differential diagnosis of feces-like material just proximal to the transitional zone in abdominal CT. It can help radiologists to quickly and easily diagnose a bezoar.

title: Ultrasonographic differentiation of bezoar from feces in XXXX .

answer: @entity1


abstract: UNASSIGNED: Glutamatergic neurotransmission is evolutionarily conserved across animal phyla. A major class of @entity2 receptors are the metabotropic @entity2 receptors (mGluRs). In @entity1 three mGluR genes @entity3 , @entity4 and @entity5 are organised into three sub-groups, similar to their @entity0 counterparts. Cellular reporters identified expression of the mgls in the nervous system of @entity1 and overlapping expression in the pharyngeal microcircuit that controls pharyngeal muscle activity and feeding behaviour. The overlapping expression of mgls within this circuit allowed investigation of receptor signalling per se and in the context of receptor interactions within a neural network that regulates feeding. We utilized the pharmacological manipulation of neuronally regulated pumping of the pharyngeal muscle in wild type and mutants to investigate mgl function. This defined a net @entity3 dependent inhibition of pharyngeal pumping which is modulated by @entity5 excitation. Optogenetic activation of the pharyngeal glutamatergic inputs combined with electrophysiological recordings from the isolated pharyngeal preparations provided further evidence for a presynaptic @entity3 dependent regulation of pharyngeal activity. Analysis of @entity3 , @entity4 and @entity5 mutant feeding behaviour in the intact organism after acute food removal identified a significant role for @entity3 in the regulation of an adaptive feeding response. Our data describes the molecular and cellular organisation of @entity3 , @entity4 and @entity5 . Pharmacological analysis identified that in these paradigms @entity3 and @entity5 , but not @entity4 , can modulate the pharyngeal microcircuit. Behavioural analysis identified @entity3 as a significant determinant of the @entity2 -dependent modulation of feeding, further highlighting the significance of mGluRs in complex @entity1 behaviour.

title: Metabotropic @entity2 receptors: modulators of context-dependent feeding behaviour in XXXX .

answer: @entity1


abstract: UNASSIGNED: Glutamatergic neurotransmission is evolutionarily conserved across animal phyla. A major class of @entity2 receptors are the metabotropic @entity2 receptors (mGluRs). In @entity1 three mGluR genes @entity3 , @entity4 and @entity5 are organised into three sub-groups, similar to their @entity0 counterparts. Cellular reporters identified expression of the mgls in the nervous system of @entity1 and overlapping expression in the pharyngeal microcircuit that controls pharyngeal muscle activity and feeding behaviour. The overlapping expression of mgls within this circuit allowed investigation of receptor signalling per se and in the context of receptor interactions within a neural network that regulates feeding. We utilized the pharmacological manipulation of neuronally regulated pumping of the pharyngeal muscle in wild type and mutants to investigate mgl function. This defined a net @entity3 dependent inhibition of pharyngeal pumping which is modulated by @entity5 excitation. Optogenetic activation of the pharyngeal glutamatergic inputs combined with electrophysiological recordings from the isolated pharyngeal preparations provided further evidence for a presynaptic @entity3 dependent regulation of pharyngeal activity. Analysis of @entity3 , @entity4 and @entity5 mutant feeding behaviour in the intact organism after acute food removal identified a significant role for @entity3 in the regulation of an adaptive feeding response. Our data describes the molecular and cellular organisation of @entity3 , @entity4 and @entity5 . Pharmacological analysis identified that in these paradigms @entity3 and @entity5 , but not @entity4 , can modulate the pharyngeal microcircuit. Behavioural analysis identified @entity3 as a significant determinant of the @entity2 -dependent modulation of feeding, further highlighting the significance of mGluRs in complex @entity1 behaviour.

title: Metabotropic XXXX receptors: modulators of context-dependent feeding behaviour in @entity1 .

answer: @entity2


abstract: In the present investigation the frequency of oral @entity2 and @entity1 in 161 orthodontic @entity0 was recorded. Of all @entity0 , 95% had experienced @entity1 , but 84.5% said that the @entity1 lasted a few days only. About 11% maintained that the treatment was constantly painful. Significantly more @entity0 coming from private clinics complained of @entity1 than those attending treatment at the Department of Orthodontics. About 50% said that activating or changing archwire was most annoying, whereas 28.7% said @entity2 and 21% said headgear was the most annoying part of the treatment. According to 75% of the @entity0 , sleeping habits were not influenced. Only eight @entity0 reported truancy, and seven of these had done this only once. Of all @entity0 , 6.2% had requested interim visits. Small wounds caused by the fixed appliance were reported by 75.8% of the @entity0 , and 2.5% had suffered badly from @entity2 caused by the fixed appliances. More @entity0 than @entity0 reported @entity2 . There was a significant sex difference as regards recurrent aphthous @entity2 (RAU). Increase in the frequency of RAU was reported by 23.1% of the @entity0 and 9.6% of the @entity0 while they had fixed appliances.

title: Traumatic XXXX and @entity1 during orthodontic treatment.

answer: @entity2


abstract: In the present investigation the frequency of oral @entity2 and @entity1 in 161 orthodontic @entity0 was recorded. Of all @entity0 , 95% had experienced @entity1 , but 84.5% said that the @entity1 lasted a few days only. About 11% maintained that the treatment was constantly painful. Significantly more @entity0 coming from private clinics complained of @entity1 than those attending treatment at the Department of Orthodontics. About 50% said that activating or changing archwire was most annoying, whereas 28.7% said @entity2 and 21% said headgear was the most annoying part of the treatment. According to 75% of the @entity0 , sleeping habits were not influenced. Only eight @entity0 reported truancy, and seven of these had done this only once. Of all @entity0 , 6.2% had requested interim visits. Small wounds caused by the fixed appliance were reported by 75.8% of the @entity0 , and 2.5% had suffered badly from @entity2 caused by the fixed appliances. More @entity0 than @entity0 reported @entity2 . There was a significant sex difference as regards recurrent aphthous @entity2 (RAU). Increase in the frequency of RAU was reported by 23.1% of the @entity0 and 9.6% of the @entity0 while they had fixed appliances.

title: Traumatic @entity2 and XXXX during orthodontic treatment.

answer: @entity1


abstract: The effect of curcumin pretreatment (15-240   M) in fathead minnow cells infected with @entity6 virus (VHSV) was evaluated. Cell viability, apoptosis and viral copy number were analyzed using Cell Counting Kit-8 assay, @entity2 staining, and reverse transcription-PCR, respectively. Pretreatment with 120   M curcumin showed an increase in viability (>90% of mock) of VHSV-infected cells and reduction in the copy number (0.2-log reduction in VHSV N gene expression), reactive oxygen species and apoptosis in the cells without cytotoxic effects. To understand the mechanisms underlaying the antiviral effects of curcumin pretreatment, a comparative proteomic analysis was performed in four samples (M, mock; C, curcumin-treated; V, VHSV-infected; and CV, curcumin-treated VHSV-infected) in triplicate. In total, 185 proteins were detected. The analysis showed that three proteins, including @entity1 cognate 71 ( @entity4 ), actin, alpha cardiac muscle ( @entity9 ) and elongation factor 1 ( @entity0 ) were differentially expressed between V and CV samples. Network analysis performed by Ingenuity Pathways Analysis (IPA) showed that @entity4 was the primary protein interacting with fibronectin (FN) 1, actins ( @entity7 , @entity5 , F-actin) and @entity8 (GSN) in both V and CV samples and thus is a strong target candidate for the protection from @entity6 at the viral entry stage. Our proteomics data suggest that curcumin pretreatment inhibits entry of VHSV in cells by downregulating @entity3 or upregulating F-actin. For both proteins, @entity4 acts as a binding protein that modulates their functions. Furthermore, consistent with the effect of a @entity1 protein inhibitor (KNK437), curcumin downregulated @entity4 expression with increasing viability of VHSV-infected cells and inhibited VHSV replication, suggesting that the downregulation of @entity4 could be responsible for the antiviral activity of curcumin. In conclusion, this study indicates that the suppression of viral entry by rearrangement of the F-actin/G-actin ratio via downregulating @entity4 is a plausible mechanism by which curcumin pretreatment controls the early stages of @entity6 .

title: Identification of regulators of the early stage of XXXX virus infection during curcumin treatment.

answer: @entity6


abstract: OBJECTIVE: To investigate the relationship between two polymorphisms immediately upstream of the @entity2 ( @entity2 ) gene and @entity1 in a South West Han Chinese population. METHODS: Blood samples from 205 @entity0 with @entity1 and 276 normal pregnant @entity0 as controls from Han Chinese in Chengdu area were analyzed by polymerase chain reaction-restriction fragment length polymorphisms. RESULTS: G and A allele frequencies for @entity4 site were 48.54% and 51.46% in the @entity0 group, respectively, and 40.40% and 59.60% in the control group, respectively. G and C allele frequencies for @entity3 site were 94.15% and 5.85% in the case group, respectively, and 94.38% and 5.62% in the control group, respectively. The AA genotype and variant A allelic frequencies of the @entity4 SNP were significantly lower in @entity0 with @entity1 than in the control group (P<0.05), and the odds ratio for the risk of @entity1 was 0.665 (95% CI: 0.444-0.982) in @entity0 homozygous for the variant @entity2 A allele ( x2=4.233, P=0.047). The genotype and allele frequencies of the @entity3 polymorphism in @entity0 with @entity1 and controls showed no significant differences (P>0.05). Additional subgroup analyses (mild vs severe @entity1 ) of the two polymorphisms failed to reveal significant correlation for either genotypic or allelic frequencies. Furthermore, there was no significant association between the polymorphisms and blood pressure levels in the @entity0 or control groups. CONCLUSION: @entity2 -1195A homozygosity is associated with a decreased risk for @entity1 in a South West Han Chinese population. On the other hand, the @entity3 polymorphism has no effect.

title: [Association study between @entity3 and XXXX functional polymorphisms in the @entity2 gene and risk of @entity1 ].

answer: @entity4


abstract: OBJECTIVE: To investigate the relationship between two polymorphisms immediately upstream of the @entity2 ( @entity2 ) gene and @entity1 in a South West Han Chinese population. METHODS: Blood samples from 205 @entity0 with @entity1 and 276 normal pregnant @entity0 as controls from Han Chinese in Chengdu area were analyzed by polymerase chain reaction-restriction fragment length polymorphisms. RESULTS: G and A allele frequencies for @entity4 site were 48.54% and 51.46% in the @entity0 group, respectively, and 40.40% and 59.60% in the control group, respectively. G and C allele frequencies for @entity3 site were 94.15% and 5.85% in the case group, respectively, and 94.38% and 5.62% in the control group, respectively. The AA genotype and variant A allelic frequencies of the @entity4 SNP were significantly lower in @entity0 with @entity1 than in the control group (P<0.05), and the odds ratio for the risk of @entity1 was 0.665 (95% CI: 0.444-0.982) in @entity0 homozygous for the variant @entity2 A allele ( x2=4.233, P=0.047). The genotype and allele frequencies of the @entity3 polymorphism in @entity0 with @entity1 and controls showed no significant differences (P>0.05). Additional subgroup analyses (mild vs severe @entity1 ) of the two polymorphisms failed to reveal significant correlation for either genotypic or allelic frequencies. Furthermore, there was no significant association between the polymorphisms and blood pressure levels in the @entity0 or control groups. CONCLUSION: @entity2 -1195A homozygosity is associated with a decreased risk for @entity1 in a South West Han Chinese population. On the other hand, the @entity3 polymorphism has no effect.

title: [Association study between @entity3 and @entity4 functional polymorphisms in the @entity2 gene and risk of XXXX ].

answer: @entity1


abstract: OBJECTIVE: To investigate the relationship between two polymorphisms immediately upstream of the @entity2 ( @entity2 ) gene and @entity1 in a South West Han Chinese population. METHODS: Blood samples from 205 @entity0 with @entity1 and 276 normal pregnant @entity0 as controls from Han Chinese in Chengdu area were analyzed by polymerase chain reaction-restriction fragment length polymorphisms. RESULTS: G and A allele frequencies for @entity4 site were 48.54% and 51.46% in the @entity0 group, respectively, and 40.40% and 59.60% in the control group, respectively. G and C allele frequencies for @entity3 site were 94.15% and 5.85% in the case group, respectively, and 94.38% and 5.62% in the control group, respectively. The AA genotype and variant A allelic frequencies of the @entity4 SNP were significantly lower in @entity0 with @entity1 than in the control group (P<0.05), and the odds ratio for the risk of @entity1 was 0.665 (95% CI: 0.444-0.982) in @entity0 homozygous for the variant @entity2 A allele ( x2=4.233, P=0.047). The genotype and allele frequencies of the @entity3 polymorphism in @entity0 with @entity1 and controls showed no significant differences (P>0.05). Additional subgroup analyses (mild vs severe @entity1 ) of the two polymorphisms failed to reveal significant correlation for either genotypic or allelic frequencies. Furthermore, there was no significant association between the polymorphisms and blood pressure levels in the @entity0 or control groups. CONCLUSION: @entity2 -1195A homozygosity is associated with a decreased risk for @entity1 in a South West Han Chinese population. On the other hand, the @entity3 polymorphism has no effect.

title: [Association study between @entity3 and @entity4 functional polymorphisms in the XXXX gene and risk of @entity1 ].

answer: @entity2


abstract: OBJECTIVE: To investigate the relationship between two polymorphisms immediately upstream of the @entity2 ( @entity2 ) gene and @entity1 in a South West Han Chinese population. METHODS: Blood samples from 205 @entity0 with @entity1 and 276 normal pregnant @entity0 as controls from Han Chinese in Chengdu area were analyzed by polymerase chain reaction-restriction fragment length polymorphisms. RESULTS: G and A allele frequencies for @entity4 site were 48.54% and 51.46% in the @entity0 group, respectively, and 40.40% and 59.60% in the control group, respectively. G and C allele frequencies for @entity3 site were 94.15% and 5.85% in the case group, respectively, and 94.38% and 5.62% in the control group, respectively. The AA genotype and variant A allelic frequencies of the @entity4 SNP were significantly lower in @entity0 with @entity1 than in the control group (P<0.05), and the odds ratio for the risk of @entity1 was 0.665 (95% CI: 0.444-0.982) in @entity0 homozygous for the variant @entity2 A allele ( x2=4.233, P=0.047). The genotype and allele frequencies of the @entity3 polymorphism in @entity0 with @entity1 and controls showed no significant differences (P>0.05). Additional subgroup analyses (mild vs severe @entity1 ) of the two polymorphisms failed to reveal significant correlation for either genotypic or allelic frequencies. Furthermore, there was no significant association between the polymorphisms and blood pressure levels in the @entity0 or control groups. CONCLUSION: @entity2 -1195A homozygosity is associated with a decreased risk for @entity1 in a South West Han Chinese population. On the other hand, the @entity3 polymorphism has no effect.

title: [Association study between XXXX and @entity4 functional polymorphisms in the @entity2 gene and risk of @entity1 ].

answer: @entity3


abstract: @entity2 ( @entity2 ) is the most frequent and @entity5 . Conventional therapy of surgical removal, radiation and chemotherapy is largely palliative. @entity6 ( @entity6 ), the main component of the vault organelle has been associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. With regard to @entity1 , @entity6 has been shown to be overexpressed in drug resistance development and malignant progression. The aim of the present study was to evaluate the @entity6 gene dosage levels in 113 archival samples from @entity2 and its correlation with @entity0 ' survival and @entity3 ( @entity3 ) and phosphatase and tensin homolog ( @entity4 ) gene dosages. Fluorescent in situ hybridization revealed polysomy of chromosome 7 in 76.1% of the GBMs and @entity3 amplification in a 64.6% of the @entity1 . Genetic status of @entity3 , @entity4 and @entity6 copies was determined by multiplex ligation-dependent probe amplification (MLPA) technique. 31% of the @entity1 showed the @entity3 is variant III mutation (EGFRvIII) mutation and 74.3% of them presented amplification of @entity6 gene. Amplification of @entity3 and @entity6 was found in a 63.7% and 56.6% of the @entity2 , respectively. An inverse correlation between @entity6 and @entity4 dosage values was observed. Besides, an inverse relationship between the survival of the @entity0 treated with chemotherapy and the levels of @entity6 copies was determined. In conclusion, our study reveals an important role of @entity6 , together with EGFRvIII and @entity4 , in the progression of @entity2 and proposes it as a novel and interesting target for new treatment approaches.

title: Alteration of major vault protein in @entity0 XXXX and its relation with @entity3 and @entity4 status.

answer: @entity2


abstract: @entity2 ( @entity2 ) is the most frequent and @entity5 . Conventional therapy of surgical removal, radiation and chemotherapy is largely palliative. @entity6 ( @entity6 ), the main component of the vault organelle has been associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. With regard to @entity1 , @entity6 has been shown to be overexpressed in drug resistance development and malignant progression. The aim of the present study was to evaluate the @entity6 gene dosage levels in 113 archival samples from @entity2 and its correlation with @entity0 ' survival and @entity3 ( @entity3 ) and phosphatase and tensin homolog ( @entity4 ) gene dosages. Fluorescent in situ hybridization revealed polysomy of chromosome 7 in 76.1% of the GBMs and @entity3 amplification in a 64.6% of the @entity1 . Genetic status of @entity3 , @entity4 and @entity6 copies was determined by multiplex ligation-dependent probe amplification (MLPA) technique. 31% of the @entity1 showed the @entity3 is variant III mutation (EGFRvIII) mutation and 74.3% of them presented amplification of @entity6 gene. Amplification of @entity3 and @entity6 was found in a 63.7% and 56.6% of the @entity2 , respectively. An inverse correlation between @entity6 and @entity4 dosage values was observed. Besides, an inverse relationship between the survival of the @entity0 treated with chemotherapy and the levels of @entity6 copies was determined. In conclusion, our study reveals an important role of @entity6 , together with EGFRvIII and @entity4 , in the progression of @entity2 and proposes it as a novel and interesting target for new treatment approaches.

title: Alteration of major vault protein in @entity0 @entity2 and its relation with XXXX and @entity4 status.

answer: @entity3


abstract: @entity2 ( @entity2 ) is the most frequent and @entity5 . Conventional therapy of surgical removal, radiation and chemotherapy is largely palliative. @entity6 ( @entity6 ), the main component of the vault organelle has been associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. With regard to @entity1 , @entity6 has been shown to be overexpressed in drug resistance development and malignant progression. The aim of the present study was to evaluate the @entity6 gene dosage levels in 113 archival samples from @entity2 and its correlation with @entity0 ' survival and @entity3 ( @entity3 ) and phosphatase and tensin homolog ( @entity4 ) gene dosages. Fluorescent in situ hybridization revealed polysomy of chromosome 7 in 76.1% of the GBMs and @entity3 amplification in a 64.6% of the @entity1 . Genetic status of @entity3 , @entity4 and @entity6 copies was determined by multiplex ligation-dependent probe amplification (MLPA) technique. 31% of the @entity1 showed the @entity3 is variant III mutation (EGFRvIII) mutation and 74.3% of them presented amplification of @entity6 gene. Amplification of @entity3 and @entity6 was found in a 63.7% and 56.6% of the @entity2 , respectively. An inverse correlation between @entity6 and @entity4 dosage values was observed. Besides, an inverse relationship between the survival of the @entity0 treated with chemotherapy and the levels of @entity6 copies was determined. In conclusion, our study reveals an important role of @entity6 , together with EGFRvIII and @entity4 , in the progression of @entity2 and proposes it as a novel and interesting target for new treatment approaches.

title: Alteration of major vault protein in @entity0 @entity2 and its relation with @entity3 and XXXX status.

answer: @entity4


abstract: @entity2 ( @entity2 ) is the most frequent and @entity5 . Conventional therapy of surgical removal, radiation and chemotherapy is largely palliative. @entity6 ( @entity6 ), the main component of the vault organelle has been associated with multidrug resistance by reducing cellular accumulation of chemotherapeutic agents. With regard to @entity1 , @entity6 has been shown to be overexpressed in drug resistance development and malignant progression. The aim of the present study was to evaluate the @entity6 gene dosage levels in 113 archival samples from @entity2 and its correlation with @entity0 ' survival and @entity3 ( @entity3 ) and phosphatase and tensin homolog ( @entity4 ) gene dosages. Fluorescent in situ hybridization revealed polysomy of chromosome 7 in 76.1% of the GBMs and @entity3 amplification in a 64.6% of the @entity1 . Genetic status of @entity3 , @entity4 and @entity6 copies was determined by multiplex ligation-dependent probe amplification (MLPA) technique. 31% of the @entity1 showed the @entity3 is variant III mutation (EGFRvIII) mutation and 74.3% of them presented amplification of @entity6 gene. Amplification of @entity3 and @entity6 was found in a 63.7% and 56.6% of the @entity2 , respectively. An inverse correlation between @entity6 and @entity4 dosage values was observed. Besides, an inverse relationship between the survival of the @entity0 treated with chemotherapy and the levels of @entity6 copies was determined. In conclusion, our study reveals an important role of @entity6 , together with EGFRvIII and @entity4 , in the progression of @entity2 and proposes it as a novel and interesting target for new treatment approaches.

title: Alteration of major vault protein in XXXX @entity2 and its relation with @entity3 and @entity4 status.

answer: @entity0


abstract: Objective. To assess the diagnostic performance of a T1-independent, T2(*)-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of @entity1 in a cohort of @entity0 affected by chronic @entity2 , using liver biopsy as gold standard. Methods. Eighty-one untreated @entity0 with chronic @entity2 were prospectively enrolled. All included @entity0 underwent MRI, transient elastography, and liver biopsy within a time interval <10 days. Results. Our cohort of 77 @entity0 included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31    11.27 (18-81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2(*) decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S >=  1 and 0.929 (95% CI 0.847 to 0.975) for S = 2. Conclusions. Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of @entity1 .

title: Diagnostic value of MRI proton density fat fraction for assessing XXXX in chronic @entity2 .

answer: @entity1


abstract: Objective. To assess the diagnostic performance of a T1-independent, T2(*)-corrected multiecho magnetic resonance imaging (MRI) technique for the quantification of @entity1 in a cohort of @entity0 affected by chronic @entity2 , using liver biopsy as gold standard. Methods. Eighty-one untreated @entity0 with chronic @entity2 were prospectively enrolled. All included @entity0 underwent MRI, transient elastography, and liver biopsy within a time interval <10 days. Results. Our cohort of 77 @entity0 included 43/77 (55.8%) males and 34/77 (44.2%) females with a mean age of 51.31    11.27 (18-81) years. The median MRI PDFF showed a strong correlation with the histological fat fraction (FF) (r = 0.754, 95% CI 0.637 to 0.836, P < 0.0001), and the correlation was influenced by neither the liver stiffness nor the T2(*) decay. The median MRI PDFF result was significantly lower in the F4 subgroup (P < 0.05). The diagnostic accuracy of MRI PDFF evaluated by AUC-ROC analysis was 0.926 (95% CI 0.843 to 0.973) for S >=  1 and 0.929 (95% CI 0.847 to 0.975) for S = 2. Conclusions. Our MRI technique of PDFF estimation allowed discriminating with a good diagnostic accuracy between different grades of @entity1 .

title: Diagnostic value of MRI proton density fat fraction for assessing @entity1 in chronic XXXX .

answer: @entity2


abstract: The aims of this study were first to clearly define two different entities: locoregional recurrences and limited metastatic disease and secondly to evaluate the place of extensive surgery in these two types of recurrence. Material and Methods. Twenty-four @entity1 were followed from June 2004 until May 2014. All @entity1 underwent surgery but for 1 @entity1 this surgery was stopped because the @entity3 was unresectable. Results. The median interval between surgery for the primary @entity3 and the locoregional recurrence or metastatic evolution was 129 months. Eight @entity1 had pure nodal recurrences, 4 had nodal and muscular recurrences, 5 had muscular + skin recurrences, and 8 had metastatic evolution. Currently, all @entity1 are still alive but 2 have liver @entity2 . Disease free survival was measured at 2 years and extrapolated at 5 years and was 92% at these two time points. No difference was observed for young or older @entity1 ; limited metastatic evolution and locoregional recurrence exhibited the same disease free survival. Conclusion. Extensive surgery has a place in locoregional and limited metastatic @entity0 recurrences but this option must absolutely be integrated in the multidisciplinary strategy of therapeutic options and needs to be planned with a curative intent.

title: The place of extensive surgery in locoregional recurrence and limited metastatic disease of XXXX : preliminary results.

answer: @entity0