abstract: During the 17 years preceding March 1985, 140 @entity0 sustained @entity4 caused by 44 thunderbolts. Fifty @entity0 showed evidence of current flow through their bodies. These 50 victims were classified into two groups, the first consisting of 9 victims who showed @entity3 of their clothes or linear superficial dermal burns along their whole bodies from head to feet, indicating the occurrence of surface flashovers. The remaining 41 @entity0 showed no evidence of this flash effect. It is noteworthy that in the first group 5 of the 9 survived, whereas in the second group only 6 among 41 survived. The result indicates that when a flashover occurs along the whole body, the probability of survival is higher than 50 per cent. The conditions which determine @entity2 or survival were investigated experimentally, imposing artificial lightning voltage impulses on @entity1 and developing flashovers on them. The @entity1 survived when the voltage drop caused by flashover occurred immediately after the peak point, and the current waveform exhibited a sharp peak. In contrast, the @entity1 were killed when the voltage drop caused by flashover was delayed by more than 20 microseconds, and the current waveform showed a blunt cone shape. It has been concluded that a fast flashover appreciably diminishes the energy dissipation within the body and consequently results in survival.

title: XXXX caused by discharges accompanying flashovers--a clinical and experimental study of @entity2 and survival.

answer: @entity4


abstract: During the 17 years preceding March 1985, 140 @entity0 sustained @entity4 caused by 44 thunderbolts. Fifty @entity0 showed evidence of current flow through their bodies. These 50 victims were classified into two groups, the first consisting of 9 victims who showed @entity3 of their clothes or linear superficial dermal burns along their whole bodies from head to feet, indicating the occurrence of surface flashovers. The remaining 41 @entity0 showed no evidence of this flash effect. It is noteworthy that in the first group 5 of the 9 survived, whereas in the second group only 6 among 41 survived. The result indicates that when a flashover occurs along the whole body, the probability of survival is higher than 50 per cent. The conditions which determine @entity2 or survival were investigated experimentally, imposing artificial lightning voltage impulses on @entity1 and developing flashovers on them. The @entity1 survived when the voltage drop caused by flashover occurred immediately after the peak point, and the current waveform exhibited a sharp peak. In contrast, the @entity1 were killed when the voltage drop caused by flashover was delayed by more than 20 microseconds, and the current waveform showed a blunt cone shape. It has been concluded that a fast flashover appreciably diminishes the energy dissipation within the body and consequently results in survival.

title: @entity4 caused by discharges accompanying flashovers--a clinical and experimental study of XXXX and survival.

answer: @entity2


abstract: We previously reported a study on the antimicrobial action of a chemically synthesized drug, @entity3 ( @entity6 ) and on its transfer in. This paper describes the results of our clinical study on @entity6 . 1. Only small fractions of intra-blood @entity6 were transported into female organs such as uterus, @entity5 . Our study with the normal delivery method shows that umbilical cord blood concentrations of @entity6 is a third to a sixth of maternal blood concentrations and is achieved through trans-placental transfer. Its transfer into amniotic fluid, however, is very low. 2. Forty-one cases, including cases of female intrapelvic @entity0 , urinary tract infection, puerperal @entity4 , etc., were administered with @entity6 at levels of 200 approximately 400 mg/day for 3 approximately 10 days. @entity6 were found to be effective in 35 cases. 3. We observed 113 cases to which @entity6 was administered, and found only 4 cases of @entity2 and 1 case of suspicion of @entity1 as side effects. Laboratory tests showed no abnormalities due to @entity6 in blood, serum biochemical or urine value in the cases examined (26 to 51 cases depending on test).

title: [Second report of XXXX : clinical study].

answer: @entity3


abstract: OBJECTIVE: This study compared adherence to follow-up and clinical outcomes between standard in-clinic and remote follow-up after @entity2 / @entity1 abortion. STUDY DESIGN: This nonrandomized trial recruited @entity0 requesting medical abortion at two sexual health clinics in Toronto, Canada. @entity0 received @entity2 50 mg/m(2) followed 3-7 days later by 800 mcg of @entity1 self-administered vaginally. For Day 15, follow-up @entity0 could choose standard in-clinic follow-up with ultrasound and assessment or remote telephone follow-up with serum b-hCG performed at a community laboratory and symptom checklist. Standard and remote follow-up groups were compared for adherence, defined as completing follow-up within 7 days of the scheduled time, and clinical outcomes. Characteristics associated with adherence were assessed using multivariable logistic regression. RESULTS: Of 129 @entity0 , 86 (67%) chose remote follow-up. Nonadherence rates for remote (28%) and standard (23%) follow-up groups did not differ in univariate (p=.57) or multivariable analysis (odds ratio: 1.09, 95% confidence interval: 0.39-3.01). Rates of emergency/hospital visits were 3% and 9% for remote and standard groups, respectively (p=.22), and complete loss to follow was 6% and 14% in remote and standard groups (p=.18). Nonadherent @entity0 were more likely to be undecided about their contraception (65% vs. 28%; p=.002), and this difference persisted in the multivariable analysis. CONCLUSION: Given a choice of remote or in-clinic follow-up after @entity2 / @entity1 abortion, most @entity0 chose remote follow-up. Rates of adherence to follow-up, adverse outcomes and complete loss to follow-up were similar for @entity0 choosing remote and standard follow-up. IMPLICATIONS STATEMENT: Since standard and remote follow-up after @entity2 / @entity1 abortion are associated with similar adherence to follow-up and similar safety profiles, @entity0 should be offered their choice of follow-up method.

title: Comparison of remote and in-clinic follow-up after XXXX / @entity1 abortion.

answer: @entity2


abstract: OBJECTIVE: This study compared adherence to follow-up and clinical outcomes between standard in-clinic and remote follow-up after @entity2 / @entity1 abortion. STUDY DESIGN: This nonrandomized trial recruited @entity0 requesting medical abortion at two sexual health clinics in Toronto, Canada. @entity0 received @entity2 50 mg/m(2) followed 3-7 days later by 800 mcg of @entity1 self-administered vaginally. For Day 15, follow-up @entity0 could choose standard in-clinic follow-up with ultrasound and assessment or remote telephone follow-up with serum b-hCG performed at a community laboratory and symptom checklist. Standard and remote follow-up groups were compared for adherence, defined as completing follow-up within 7 days of the scheduled time, and clinical outcomes. Characteristics associated with adherence were assessed using multivariable logistic regression. RESULTS: Of 129 @entity0 , 86 (67%) chose remote follow-up. Nonadherence rates for remote (28%) and standard (23%) follow-up groups did not differ in univariate (p=.57) or multivariable analysis (odds ratio: 1.09, 95% confidence interval: 0.39-3.01). Rates of emergency/hospital visits were 3% and 9% for remote and standard groups, respectively (p=.22), and complete loss to follow was 6% and 14% in remote and standard groups (p=.18). Nonadherent @entity0 were more likely to be undecided about their contraception (65% vs. 28%; p=.002), and this difference persisted in the multivariable analysis. CONCLUSION: Given a choice of remote or in-clinic follow-up after @entity2 / @entity1 abortion, most @entity0 chose remote follow-up. Rates of adherence to follow-up, adverse outcomes and complete loss to follow-up were similar for @entity0 choosing remote and standard follow-up. IMPLICATIONS STATEMENT: Since standard and remote follow-up after @entity2 / @entity1 abortion are associated with similar adherence to follow-up and similar safety profiles, @entity0 should be offered their choice of follow-up method.

title: Comparison of remote and in-clinic follow-up after @entity2 / XXXX abortion.

answer: @entity1


abstract: The incidence of @entity3 , nonparturient paresis, @entity4 and @entity0 were examined from 283 herds (2,590 @entity2 per year) over a period of eight years. These @entity1 made up 29.4% of the cases treated by veterinarians during the farm visits. Significant variation in annual incidences was found only in @entity4 . The monthly variation in @entity3 and @entity4 differed highly significantly from the seasonal variation in calving. They were most frequent in March-April. Most of the @entity0 cases were diagnosed in May-June. The incidence of @entity3 (0.095 cases per @entity2 per year) and the incidence of @entity4 (0.058) varied significantly between herds of different size. The incidence of nonparturient paresis (0.008) and @entity0 (0.002) did not vary significantly between herds of different size. The incidence of @entity4 was significantly higher on farms with milk recording than on other farms. The type of cowshed did not affect the incidence of @entity1 .

title: Incidence of some @entity1 in dairy XXXX .

answer: @entity2


abstract: The incidence of @entity3 , nonparturient paresis, @entity4 and @entity0 were examined from 283 herds (2,590 @entity2 per year) over a period of eight years. These @entity1 made up 29.4% of the cases treated by veterinarians during the farm visits. Significant variation in annual incidences was found only in @entity4 . The monthly variation in @entity3 and @entity4 differed highly significantly from the seasonal variation in calving. They were most frequent in March-April. Most of the @entity0 cases were diagnosed in May-June. The incidence of @entity3 (0.095 cases per @entity2 per year) and the incidence of @entity4 (0.058) varied significantly between herds of different size. The incidence of nonparturient paresis (0.008) and @entity0 (0.002) did not vary significantly between herds of different size. The incidence of @entity4 was significantly higher on farms with milk recording than on other farms. The type of cowshed did not affect the incidence of @entity1 .

title: Incidence of some XXXX in dairy @entity2 .

answer: @entity1


abstract: @entity5 are known to occur spontaneously in several @entity1 strains, especially during aging. Here we report the occurrence of @entity4 ( @entity6 ) in a new @entity1 model at an early age. The @entity4 were characterized by light and electron microscopy and histochemically by immunoperoxidase methods using specific antisera. Of the 53 pituitaries examined, one was normal, two were @entity7 and the remainder were @entity4 . Among the latter, there were 37 @entity6 (70%), 3 GH-producing @entity0 and 2 ACTH-containing @entity0 . One microadenoma produced both PRL and GH. The remaining 8 @entity4 were histochemically negative for all pituitary hormones. Serum PRL levels were elevated in both sexes while serum @entity3 was high in females and low in the males. The serum @entity2 levels were elevated in the males with @entity6 . The @entity6 appear to be transmitted as an autosomal dominant characteristic with incomplete penetrance and a greater incidence in the male.

title: Hereditary pituitary prolactinomas: a new XXXX model.

answer: @entity1


abstract: PURPOSE: We sought to evaluate whether @entity1 response using cone beam computed tomography (CBCT) performed as part of the routine care during chemoradiation therapy (CRT) could forecast the outcome of unresectable, locally advanced, @entity3 ( @entity3 ). METHODS AND MATERIALS: We manually delineated primary @entity1 volumes (TV) of @entity0 with @entity3 who were treated with radical CRT on days 1, 8, 15, 22, 29, 36, and 43 on CBCTs obtained as part of the standard radiation treatment course. Percentage reductions in TV were calculated and then correlated to survival and pattern of recurrence using Cox proportional hazard models. Clinical information including histologic subtype was also considered in the study of such associations. RESULTS: We evaluated 38 @entity0 with a median follow-up time of 23.4  months. The median TV reduction was 39.3% (range, 7.3%-69.3%) from day 1 (D1) to day 43 (D43) CBCTs. Overall survival was associated with TV reduction from D1 to D43 (hazard ratio [HR] 0.557, 95% CI 0.39-0.79, P=.0009). For every 10% decrease in TV from D1 to D43, the risk of @entity2 decreased by 44.3%. For @entity0 whose TV decreased >= 39.3 or <39.3%, log-rank test demonstrated a separation in survival (P=.02), with median survivals of 31  months versus 10  months, respectively. Neither local recurrence (HR 0.791, 95% CI 0.51-1.23, P=.29), nor distant recurrence (HR 0.78, 95% CI 0.57-1.08, P=.137) correlated with TV decrease from D1 to D43. Histologic subtype showed no impact on our findings. CONCLUSIONS: TV reduction as determined by CBCT during CRT as part of routine care predicts post-CRT survival. Such knowledge may justify intensification of RT or application of additional therapies. Assessment of genomic characteristics of these @entity1 may permit a better understanding of behavior or prediction of therapeutic outcomes.

title: Reduction in Tumor Volume by Cone Beam Computed Tomography Predicts Overall Survival in XXXX Treated With Chemoradiation Therapy.

answer: @entity3


abstract: Paroxysmal @entity7 most often results from atrioventricular (AV) reentry using an accessory AV pathway ( @entity6 ) or reentry within the region of the AV node. In AV reentry, using an accessory pathway, suppression of the @entity3 may be achieved by depressing either anterograde AV nodal conduction or retrograde accessory pathway conduction. Intracardiac recordings and programmed electrical stimulation have established that beta-adrenergic antagonists and @entity2 channel blockers principally affect AV nodal conduction (anterograde limb of the reentrant circuit), whereas class IA and IC agents principally affect the accessory AV pathway (retrograde limb). Pharmacologic therapy has been more effective when directed at the limb in which conduction is most marginal at the @entity3 rate (weak limb). In individual @entity0 , intracardiac recordings and programmed electrical stimulation can be used to identify the weak limb, indicating the class of agents most likely to be effective. Specialized techniques allowing direct recording of accessory pathway activation suggest that limitations in accessory pathway conduction may be explained by anatomic impediments. Conduction is most limited at the atrial interface of the accessory pathway in some @entity0 , whereas in others the ventricular interface may be the limiting factor. Class IA and IC agents appear to have the greatest effect at sites where conduction is most tenuous, i.e., at the anatomic impediments. Similar considerations apply to AV nodal reentry. Anterograde slow AV nodal pathway conduction is most often @entity1 by digitalis preparations, beta-adrenergic antagonists, and @entity2 channel blockers, whereas retrograde fast AV nodal pathway conduction is more often @entity1 by class IA and IC agents. Intracardiac recordings and programmed electrical stimulation can also be used in these @entity0 to identify the weak limb and direct pharmacologic therapy. Direct catheter recordings of AV nodal conduction remain elusive, limiting knowledge of the different conduction properties of the anterograde and retrograde limbs and the site(s) of @entity4 . Studies in progress, comparing the retrograde AV nodal conduction time during @entity3 with that during ventricular pacing at the same rate, suggest that the His bundle may be incorporated in the reentrant circuit in some @entity0 . It appears that @entity5 more readily depresses retrograde fast pathway conduction in these @entity0 than in those in whom the His bundle does not form part of the reentrant circuit, but the reasons for this are unknown.

title: Use of intracardiac recordings to determine the site of XXXX in @entity7 .

answer: @entity4


abstract: Paroxysmal @entity7 most often results from atrioventricular (AV) reentry using an accessory AV pathway ( @entity6 ) or reentry within the region of the AV node. In AV reentry, using an accessory pathway, suppression of the @entity3 may be achieved by depressing either anterograde AV nodal conduction or retrograde accessory pathway conduction. Intracardiac recordings and programmed electrical stimulation have established that beta-adrenergic antagonists and @entity2 channel blockers principally affect AV nodal conduction (anterograde limb of the reentrant circuit), whereas class IA and IC agents principally affect the accessory AV pathway (retrograde limb). Pharmacologic therapy has been more effective when directed at the limb in which conduction is most marginal at the @entity3 rate (weak limb). In individual @entity0 , intracardiac recordings and programmed electrical stimulation can be used to identify the weak limb, indicating the class of agents most likely to be effective. Specialized techniques allowing direct recording of accessory pathway activation suggest that limitations in accessory pathway conduction may be explained by anatomic impediments. Conduction is most limited at the atrial interface of the accessory pathway in some @entity0 , whereas in others the ventricular interface may be the limiting factor. Class IA and IC agents appear to have the greatest effect at sites where conduction is most tenuous, i.e., at the anatomic impediments. Similar considerations apply to AV nodal reentry. Anterograde slow AV nodal pathway conduction is most often @entity1 by digitalis preparations, beta-adrenergic antagonists, and @entity2 channel blockers, whereas retrograde fast AV nodal pathway conduction is more often @entity1 by class IA and IC agents. Intracardiac recordings and programmed electrical stimulation can also be used in these @entity0 to identify the weak limb and direct pharmacologic therapy. Direct catheter recordings of AV nodal conduction remain elusive, limiting knowledge of the different conduction properties of the anterograde and retrograde limbs and the site(s) of @entity4 . Studies in progress, comparing the retrograde AV nodal conduction time during @entity3 with that during ventricular pacing at the same rate, suggest that the His bundle may be incorporated in the reentrant circuit in some @entity0 . It appears that @entity5 more readily depresses retrograde fast pathway conduction in these @entity0 than in those in whom the His bundle does not form part of the reentrant circuit, but the reasons for this are unknown.

title: Use of intracardiac recordings to determine the site of @entity4 in XXXX .

answer: @entity7


abstract: PURPOSE: To identify clinical factors correlating with @entity0 to control intraocular pressure (IOP) in primary @entity4 (PACG) eyes with @entity1 after phacoemulsification or phacotrabeculectomy. DESIGN: Retrospective analysis of two prospective randomized controlled clinical trials. METHODS: Primary @entity4 eyes with @entity1 received phacoemulsification or phacotrabeculectomy. Failure was defined as having IOP of 21mm Hg or greater, or requiring @entity2 drugs to maintain an IOP of less than 21 mm Hg, or having had additional IOP-lowering surgery. Factors correlating with @entity0 at 24 months after surgery were identified using logistic regression model. RESULTS: One hundred twenty-three PACG eyes with @entity1 and receiving phacoemulsification (n = 62) and phacotrabeculectomy (n = 61) were analyzed. With univariate analysis, factors associated with @entity0 included a higher preoperative IOP, a higher preoperative requirement for @entity2 drugs, absence of @entity3 configuration, and phacoemulsification alone. With multivariate analysis, factors associated with @entity0 included a higher preoperative IOP [odds ratio (OR), 1.732 per increase in IOP of 5 mm Hg], a higher preoperative requirement for @entity2 drugs (OR, 1.913), and performance of phacoemulsification alone (OR, 10.24). CONCLUSIONS: In PACG eyes with @entity1 , higher preoperative IOP and increased requirement for @entity2 drugs correlate with @entity0 to control IOP after phacoemulsification or phacotrabeculectomy. Phacotrabeculectomy is more likely than phacoemulsification to achieve IOP control.

title: Factors Correlating With Failure to Control Intraocular Pressure in Primary XXXX Eyes With Coexisting @entity1 Treated by Phacoemulsification or Combined Phacotrabeculectomy.

answer: @entity4


abstract: PURPOSE: To identify clinical factors correlating with @entity0 to control intraocular pressure (IOP) in primary @entity4 (PACG) eyes with @entity1 after phacoemulsification or phacotrabeculectomy. DESIGN: Retrospective analysis of two prospective randomized controlled clinical trials. METHODS: Primary @entity4 eyes with @entity1 received phacoemulsification or phacotrabeculectomy. Failure was defined as having IOP of 21mm Hg or greater, or requiring @entity2 drugs to maintain an IOP of less than 21 mm Hg, or having had additional IOP-lowering surgery. Factors correlating with @entity0 at 24 months after surgery were identified using logistic regression model. RESULTS: One hundred twenty-three PACG eyes with @entity1 and receiving phacoemulsification (n = 62) and phacotrabeculectomy (n = 61) were analyzed. With univariate analysis, factors associated with @entity0 included a higher preoperative IOP, a higher preoperative requirement for @entity2 drugs, absence of @entity3 configuration, and phacoemulsification alone. With multivariate analysis, factors associated with @entity0 included a higher preoperative IOP [odds ratio (OR), 1.732 per increase in IOP of 5 mm Hg], a higher preoperative requirement for @entity2 drugs (OR, 1.913), and performance of phacoemulsification alone (OR, 10.24). CONCLUSIONS: In PACG eyes with @entity1 , higher preoperative IOP and increased requirement for @entity2 drugs correlate with @entity0 to control IOP after phacoemulsification or phacotrabeculectomy. Phacotrabeculectomy is more likely than phacoemulsification to achieve IOP control.

title: Factors Correlating With Failure to Control Intraocular Pressure in Primary @entity4 Eyes With Coexisting XXXX Treated by Phacoemulsification or Combined Phacotrabeculectomy.

answer: @entity1


abstract: Based on a retrospective study of a series of 196 @entity0 followed up from 1974, to 1986, 60 cases of @entity2 are reviewed in autochthonous French @entity0 , defined as born of French parents in Metropolitan France. The group included 36 @entity0 and 27 @entity0 (sex ratio 1.45) age range 32 +/- 7 years at time of diagnosis. Semeiology and outcome were compared with those of North African @entity0 , the bias related to their female under-representation being eliminated by analysis of findings in males only. No significant difference was noted between the two groups, particularly with respect to ocular, @entity1 . Neither the sex nor the existence of HLA B5 (28/40 tests) had any influence on semeiology. Three deaths related to the disease were reported two pregnancies were conducted to term without neonatal effects despite maternal acute ocular episodes. Treatment was with corticoids (n = 33), immunodeppressants (n = 15), @entity4 (n = 29) and anticoagulant and/or anti-aggregant therapy (n = 31). Lasting disappearance of aphthosis was obtained in 34 cases, of cutaneous signs in 27, articular signs in 26 and vascular signs in 16. The @entity3 present initially in 41 @entity0 had disappeared over long periods in 29 cases, and presented a satisfactory prognosis since less than 39 p. 100 of the @entity0 had any significant handicap at 5 years. Among the relapses, 5 appeared after too hasty withdrawal of @entity4 . The diagnosis of @entity2 should be evoked in autochthonous subjects if necessary, and confirmed on the basis of usual clinical criteria alone.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ XXXX in France. Apropos of 60 autochtonous subjects].

answer: @entity2


abstract: INTRODUCTION: In the initial phases after @entity7 there is an hyperinflammatory state that sometimes leads to @entity5 ( @entity5 ) and @entity1 , and that appears to be responsible for posttraumatic immunosuppression; among the trigger endogenous stimuli, @entity8 ( @entity8 ) have been proposed. The objectives of this study were to analyze if some inflammatory mediators can be considered prognostic biomarkers of outcome, and the possible role of @entity10 in posttraumatic immunosuppression. HYPOTHESIS: Cytokines and @entity8 could be early prognostic biomarkers of inflammatory and immune response in @entity7 @entity0 . MATERIALS AND METHODS: A prospective observational descriptive pilot study was carried out, evaluating the early inflammatory and stress response of 18 polytraumatized @entity0 (ISS>16) on hospital admission, at 12hours, 24hours, and 48hours posttrauma. Variable means were compared using non-parametric tests; qualitative and quantitative variables were analyzed using a Spearman's correlation test. RESULTS: Seven @entity0 met criteria for @entity5 . Statistically significant changes were recorded in leukocyte count, @entity9 ( @entity9 ), @entity3 , @entity2 , and @entity6   concentrations. @entity10 levels were significantly higher immediately after the accident followed by gradual lowering. Anti- @entity12 antibodies showed a significant reduction in all the studied time-points. @entity5 did not influence either plasma levels of leukocytes, @entity11 , RCP or anti- @entity12 , but @entity0 with @entity5 had higher plasma levels of @entity3 and @entity2 and a slower decrease of @entity10 concentrations. DISCUSSION: The higher serum concentrations of @entity2 and @entity3 found in @entity0 with @entity5 , suggests a possible role as potential early predictive markers for systemic inflammatory response and clinical complications. The higher levels of @entity10 in @entity0 with @entity5 , allows proposing @entity10 as a useful prognostic trauma biomarker early after severe injury and to consider a "damage control surgery". The significant reduction in the levels of anti- @entity12 antibodies could reflect a part of posttraumatic immunosuppression and @entity4 treatment might be suggested. LEVEL OF EVIDENCE: Level III: case-control study.

title: Early inflammatory response in polytraumatized @entity0 : Cytokines and XXXX . A pilot study.

answer: @entity8


abstract: INTRODUCTION: In the initial phases after @entity7 there is an hyperinflammatory state that sometimes leads to @entity5 ( @entity5 ) and @entity1 , and that appears to be responsible for posttraumatic immunosuppression; among the trigger endogenous stimuli, @entity8 ( @entity8 ) have been proposed. The objectives of this study were to analyze if some inflammatory mediators can be considered prognostic biomarkers of outcome, and the possible role of @entity10 in posttraumatic immunosuppression. HYPOTHESIS: Cytokines and @entity8 could be early prognostic biomarkers of inflammatory and immune response in @entity7 @entity0 . MATERIALS AND METHODS: A prospective observational descriptive pilot study was carried out, evaluating the early inflammatory and stress response of 18 polytraumatized @entity0 (ISS>16) on hospital admission, at 12hours, 24hours, and 48hours posttrauma. Variable means were compared using non-parametric tests; qualitative and quantitative variables were analyzed using a Spearman's correlation test. RESULTS: Seven @entity0 met criteria for @entity5 . Statistically significant changes were recorded in leukocyte count, @entity9 ( @entity9 ), @entity3 , @entity2 , and @entity6   concentrations. @entity10 levels were significantly higher immediately after the accident followed by gradual lowering. Anti- @entity12 antibodies showed a significant reduction in all the studied time-points. @entity5 did not influence either plasma levels of leukocytes, @entity11 , RCP or anti- @entity12 , but @entity0 with @entity5 had higher plasma levels of @entity3 and @entity2 and a slower decrease of @entity10 concentrations. DISCUSSION: The higher serum concentrations of @entity2 and @entity3 found in @entity0 with @entity5 , suggests a possible role as potential early predictive markers for systemic inflammatory response and clinical complications. The higher levels of @entity10 in @entity0 with @entity5 , allows proposing @entity10 as a useful prognostic trauma biomarker early after severe injury and to consider a "damage control surgery". The significant reduction in the levels of anti- @entity12 antibodies could reflect a part of posttraumatic immunosuppression and @entity4 treatment might be suggested. LEVEL OF EVIDENCE: Level III: case-control study.

title: Early inflammatory response in polytraumatized XXXX : Cytokines and @entity8 . A pilot study.

answer: @entity0


abstract: Due to the power of genetics, the @entity0 has become a widely used animal model in vision research. However, its eyeball has an axial length of only about 2 mm. The present protocol describes how to easily dissect the small rodent eye post mortem. This allows collecting different tissues of the eye, i.e., @entity1 , lens, iris, retina, optic nerve, @entity2 ( @entity2 ), and sclera. We further describe in detail how to process these eye samples in order to obtain high-quality RNA for RNA expression profiling studies. Depending on the eye tissue to be analyzed, we present appropriate lysis buffers to prepare total protein lysates for immunoblot and immuno-precipitation analyses. Fixation, inclusion, embedding, and cryosectioning of the globe for routine histological analyses (HE staining, DAPI staining, immunohistochemistry, in situ hybridization) is further presented. These basic protocols should allow novice investigators to obtain eye tissue samples rapidly for their experiments. Curr. Protoc. @entity0 Biol. 1:445-462    2011 by John Wiley _ Sons, Inc.

title: Exploration of the Visual System: Part 1: Dissection of the XXXX Eye for RNA, Protein, and Histological Analyses.

answer: @entity0


abstract: BACKGROUND: Many developments in medicine are likely to have influenced the treatment of @entity4 , including rates of resection. This study sought to investigate changes in surgical resection rates over time among @entity0 with @entity4 . METHODS: @entity0 diagnosed between 1995 and 2012 in the Eindhoven Cancer Registry area were included. Multivariable logistic regression analysis was used to determine the independent influence of interval of diagnosis on the likelihood of having a resection. RESULTS: Among 43   370 @entity0 , crude resection rates decreased between 1995 and 2012 for @entity2 , most notably for @entity0 aged at least 85 years with @entity2 (from 37  3 to 13  3 per cent), and @entity0 aged 75-84 years and 85 years or more with @entity1 (from 80  5 to 64  4 per cent, and from 58  9 to 36  0 per cent respectively). After adjustment for @entity0 and @entity1 characteristics, @entity0 diagnosed between 2008 and 2012 with gastric (odds ratio (OR) 0  71, 95 per cent c.i. 0  55 to 0  92), colonic (OR 0  52, 0  44 to 0  62), rectal (OR 0  39, 0  33 to 0  48) and periampullary (OR 0  42, 0  27 to 0  66) @entity1 were less likely to undergo resection than those diagnosed between 1995 and 1998. @entity0 diagnosed with @entity3 were more likely to undergo resection in recent periods (OR 4  13, 2  57 to 6  64). CONCLUSION: Resection rates have fallen over time for several @entity4 . This might reflect increased availability of other treatments, better selection of @entity0 as a result of improved diagnostic accuracy, risk-avoiding behaviour and transparency related to surgical outcomes at hospital and surgeon level.

title: Changes in XXXX resection rates.

answer: @entity4


abstract: OBJECTIVE: The objective of this study was to evaluate and compare the diagnostic value of the open biopsy technique and the percutaneous biopsy techniques in @entity2 . METHODS: Between January 2004 and December 2009, we retrospectively reviewed the medical records of 57 @entity0 with @entity2 . The etiologic diagnosis of the @entity2 was obtained by two methods. Of 57 cases, twenty-seven @entity0 underwent open biopsy and thirty @entity0 underwent percutaneous needle biopsy including computed tomography (CT) - guided and fluoroscopy-guided needle aspiration. All biopsies were performed by experienced two neurosurgeons and one interventional radiologist. RESULTS: Of the 57 cases radiologically consistent with spinal infection, 29 (50.9%) biopsy specimens resulted in positive cultures and 28 (49.1%) returned negative cultures. According to the type of biopsy techniques, the culture-positive rate was higher (p=0.005) in the open biopsy group than the percutaneous needle biopsy group. 19 (70.4%) of 27 biopsy specimens were positive in the open biopsy group, and 10 (33.3%) of 30 biopsy specimens were positive in the percutaneous needle biopsy group. Furthermore, the open biopsy showed higher positive culture rate than the percutaneous needle biopsy in cases with administration of empirical antibiotics although there was no statistically significant (p=0.137). CONCLUSIONS: Open biopsy should be considered for administration of organism-specific antibiotics for the successful treatment when percutaneous needle yield negative result. Furthermore, empirical antibiotics should be delayed until results of cultures unless the @entity0 is severely septic, critically ill, @entity1 or neurologically compromised.

title: Diagnostic Value of Biopsy Techniques in Lumbar XXXX : Percutaneous Needle Biopsy and Open Biopsy.

answer: @entity2


abstract: New nephron anlages appear in the renal cortex up to the 4th @entity1 ( @entity1 ). The last anlages to be formed develop into functional nephrons by @entity1 10, and the cortex appears mature at @entity1 12 after formation of the cortex corticis. The renal medulla develops by the longitudinal growth of loops of Henle and collecting ducts. The immature medulla cannot be divided into different zones and corresponds structurally to the later inner stripe of the outer zone. The inner zone is formed by @entity1 8, and the outer stripe of the outer zone by @entity1 12. The renal medulla is mature at @entity1 21. From the start of its development, the renal proximal tubule consists of the pars convoluta and pars recta. In both parts the formation of the brush border is accompanied by the simultaneous appearance of brush border enzymes (alkaline phosphatase, gamma-glutamyltranspeptidase, dipeptidylaminopeptidase IV) and lysosomal enzymes (acid phosphatase, acid beta-galactosidase, @entity2 ) over the full length of the proximal tubule. During the course of proximal tubule maturation, however, the lysosomal enzyme activities decline in the pass convoluta (with constant brush border enzyme activities), while the brush border enzyme activities increase in the pars recta (with constant lysosomal enzyme activities). The two parts further differ in that they exhibit different lysosomal patterns from the outset, the pars convoluta containing numerous large, highly enzyme-active lysosomes arranged in groups, and the pars recta containing only a few very small lysosomes with low enzyme activity. Thus, even in the newborn @entity0 , the lysosomal pattern of the pars recta already corresponds to that of the mature S3 segment. The S1 and S2 segments of the pars convoluta first differentiate between @entity1 10 and 21, as the groups of large lysosomes are progressively broken up and the extent of the lysosomal apparatus is diminished, this proceeding in a retrograde direction from the end of the immature pars convoluta.

title: The postnatal development of the XXXX kidney, with special reference to the chemodifferentiation of the proximal tubule.

answer: @entity0


abstract: AIMS: To determine the prevalency of risk factors for @entity7 in @entity1 @entity0 free of active @entity5 in a hospital setting and to investigate the knowledge of foot care of the @entity0 . METHODS: A retrospective study was conducted on a cohort of 296 @entity0 with @entity1 hospitalized in a tertiary hospital. A convenience sampling was adopted to recruit subjects during 2012/2013. All completed an interviewer-administered questionnaire and underwent medical assessment including foot examination and assessment of presence of @entity6 ( @entity6 ) and @entity8 (PVD). The @entity0 were assigned to a foot risk category which was developed by the International Working Group on the @entity1 (IWGDF). RESULTS: 296 inpatients were evaluated. @entity10 was noticed in 124 @entity0 (42%), @entity9 was the most prevalent abnormality, found in 65% of @entity0 . Prevalency of @entity3 , @entity2 and @entity4 were 66.2%, 57.1%, 48.3% and 44.9% respectively. 37 (12.5%) @entity0 had a history of @entity5 (n = 33) and/or toe amputation (n = 4). According to the classification system of the IWGDF, 35.1% of @entity0 were considered as having low-risk by the modified IWGDF classification (group 0), and 49% of the study population were at high risk for pedal @entity5 (group 2 and 3). There was a clear trend between the increasing severity of the staging and HbA1c, duration of @entity1 , prevalence of @entity3 , @entity2 and @entity4 and absent of physical activity. The mean knowledge score of foot care was 21.21  3.84. CONCLUSION: The risk factors for foot @entity5 and lack of fool care knowledge was rather common in a hospital-based @entity1 population, emphasizing the importance of implementing simple and affordable screening tools and methods to identify high-risk @entity0 and providing foot care education for them.

title: Prevalence of risk factors for XXXX in a Chinese tertiary hospital.

answer: @entity7


abstract: AIM: To evaluate platelet function in @entity0 with a history of surgical treatment for @entity2 ( @entity1 ). METHODS: This retrospective case-controlled study was performed in a state hospital in @entity3 from January 2009 to November 2013. The @entity0 were divided into two groups: those evaluated in the preoperative period (Group 1) and those evaluated in the postoperative period (Group 2). The @entity0 groups were compared with a control group (Group 3). All three groups were evaluated using laboratory records from day 1 of the preoperative period and day 30 of the postoperative period. The haematocrit level (HTC), platelet count (PLT), mean platelet volume ( @entity5 ), platelet distribution width (PDW), and percentage of @entity4 ( @entity4 ) were compared among the groups. RESULTS: Fifty-three @entity0 who had undergone surgical treatment of hepatic @entity1 and 55 healthy controls were included in the study. The mean follow-up time for all @entity0 was 45 (14-70) months. The @entity0 comprised 33 (62%) females and 20 (38%) males. The control group comprised 37 (67%) females and 18 (33%) males. The median age of the @entity0 was 48 (19-78) years, while that of the control group was 42 (16-64) years. No significant differences in the HTC, PLT, or @entity4 were present among the groups. The @entity5 and PDW indicated that platelet function was significantly different between Group 1 and Groups 2 and 3. Additionally, nine @entity0 had undergone previous surgical treatment for @entity1 . In a separate long-term follow-up, these @entity0 exhibited no statistically significant differences in @entity5 or PDW between the preoperative and postoperative periods. CONCLUSIONS: @entity5 and PDW can be used in the initial follow-up of @entity0 with hepatic @entity1 , but have limited use in long-term follow-up.

title: Platelet function parameters in management of XXXX : a case-controlled study.

answer: @entity2


abstract: AIM: To investigate the value of conventional MRI techniques combined with MR sialography on T2-3D-DRIVE in the diagnosis of @entity1 ( @entity1 ). METHODS: 107 @entity0 were divided into @entity1 group and non- @entity1 group. Conventional MRI techniques, such as T1WI, T2WI, and STIR images were used for changes of fat signal in the parotid gland, while the MR sialography were used for ducts dilation of the parotid gland. RESULTS: Among 93 @entity1 @entity0 , MRI identified abnormal fat deposit in the parotid glands in 86 @entity0 . The fat signal based on MRI images showed 7 @entity0 were in stage 0, 28 in stage 1, 14 in stage 2, 32 in stage 3 and 12 in stage 4. T2-3D-DRIVEMR MR sialography identified peripheral ducts dilation in 86 @entity0 . The duct dilation based on MR sialography showed 7 @entity0 in stage 0, 14 @entity0 in stage 1, 44 @entity0 in stage 2, 26 @entity0 in stage 3, and 2 @entity0 in stage 4. On MRI and MR sialography, both had a positive diagnostic rate of 92.5%. When MRI and MR sialography techniques were used together, the positive diagnostic rate increased to 96.8%. However, Kappa test showed that the MRI fat signal staging and MR sialogrpahy duct dilation staging had statistical difference (Kappa = 0.241, P = 0.000). CONCLUSION: T2-3D-DRIVE MR sialography detects peripheral ducts dilation in parotid glands with unmatched spatial resolution, also MRI fat suppression techniques detect diffusive fat deposit in parotid glands with high accuracy. Combining two techniques will provide optimal diagnosis workup for @entity1 .

title: Conventional MRI techniques combined with MR sialography on T2-3D-DRIVE in XXXX .

answer: @entity1


abstract: With the rapid changes in lifestyle of China, the prevalence of @entity0 and @entity2 is increasing. This study aims to evaluate the prevalence of @entity2 and study the disease awareness of @entity2 in a Southern China community. Furthermore, it also aimed to investigate the intervention status of lifestyle changes for @entity0 prevention. 881 adults without @entity0 were recruited from the Suzhou community of China in 2012-2013. Self-report questionnaires including demographics, Disease Awareness Scale, Willingness on Lifestyle Changes for Prediabetes Cure Scale were collected. The results showed that 16.8% were in @entity2 , and 38.5% of them knew they had it. Young age, non-smoking, high education level, low BMI, and receiving provider advice were found with less possibility to have @entity2 in Chinese adults. Less than a third of those reported with the knowledge of that @entity0 is a risk factor of developing @entity0 ( @entity0 ) and @entity1 . Less a half of the population with @entity2 may take steps in lifestyle changes for @entity0 prevention. It is necessary to call for action on the improvement of disease awareness and promotion of healthy behaviors to prevent the prevalence of @entity2 and @entity0 in Chinese adults.

title: Awareness and intervention status of XXXX among Chinese adults: implications from a community-based investigation.

answer: @entity2


abstract: BACKGROUND: There is evidence showing that the @entity2 state results in increased serum @entity1 levels. However, whether this is only due to the peripheral thyroid hormones or if thyroid-stimulating hormone (TSH) is also involved is not known. METHODS: Serum @entity1 levels and estimated glomerular filtration rate (eGFR) were assessed in thyroidectomized @entity0 with varying thyroid hormones and TSH levels. Blood samples from Group 1 (21 @entity0 ) were obtained 1 month after complete thyroidectomy, while under a @entity2 state (t1) and a sufficient time after @entity4 initiation (euthyroid state, t2). Group 2 (20 euthyroid @entity0 ) were sampled after recombinant @entity0 thyrotropin injections (rhTSH, t1) and later after rhTSH extinction (t2). RESULTS: In Group 1, serum @entity1 levels decreased after correction of @entity2 (85.3    4.3 versus 78.0    3.9   mol/L; P = 0.04). In Group 2, serum @entity1 levels increased after rhTSH withdrawal (70.6    5.7   mol/L versus 76.5    5.8   mol/L; P = 0.007). Between t1 and t2, eGFR varied accordingly [Group 1, 71.7    3.5 versus 81.2    4.5 mL/min/1.73 m   (P = 0.02); Group 2, 97.7    7.4 versus 87.5    5.9 (P = 0.007)]. The changes in TSH and eGFR following supplementation with @entity3 were significantly correlated (r = -0.6, P = 0.0041). CONCLUSIONS: @entity2 significantly increases serum @entity1 and reversibly impairs eGFR, while treatment with rhTSH enhances renal function in euthyroid @entity0 , supporting the existence of an influence of TSH level on renal function. The mechanisms by which peripheral thyroid hormones and TSH influence GFR need to be identified in physiology-orientated studies.

title: Exogenous thyrotropin improves renal function in euthyroid patients, while serum XXXX levels are increased in @entity2 .

answer: @entity1


abstract: BACKGROUND: There is evidence showing that the @entity2 state results in increased serum @entity1 levels. However, whether this is only due to the peripheral thyroid hormones or if thyroid-stimulating hormone (TSH) is also involved is not known. METHODS: Serum @entity1 levels and estimated glomerular filtration rate (eGFR) were assessed in thyroidectomized @entity0 with varying thyroid hormones and TSH levels. Blood samples from Group 1 (21 @entity0 ) were obtained 1 month after complete thyroidectomy, while under a @entity2 state (t1) and a sufficient time after @entity4 initiation (euthyroid state, t2). Group 2 (20 euthyroid @entity0 ) were sampled after recombinant @entity0 thyrotropin injections (rhTSH, t1) and later after rhTSH extinction (t2). RESULTS: In Group 1, serum @entity1 levels decreased after correction of @entity2 (85.3    4.3 versus 78.0    3.9   mol/L; P = 0.04). In Group 2, serum @entity1 levels increased after rhTSH withdrawal (70.6    5.7   mol/L versus 76.5    5.8   mol/L; P = 0.007). Between t1 and t2, eGFR varied accordingly [Group 1, 71.7    3.5 versus 81.2    4.5 mL/min/1.73 m   (P = 0.02); Group 2, 97.7    7.4 versus 87.5    5.9 (P = 0.007)]. The changes in TSH and eGFR following supplementation with @entity3 were significantly correlated (r = -0.6, P = 0.0041). CONCLUSIONS: @entity2 significantly increases serum @entity1 and reversibly impairs eGFR, while treatment with rhTSH enhances renal function in euthyroid @entity0 , supporting the existence of an influence of TSH level on renal function. The mechanisms by which peripheral thyroid hormones and TSH influence GFR need to be identified in physiology-orientated studies.

title: Exogenous thyrotropin improves renal function in euthyroid patients, while serum @entity1 levels are increased in XXXX .

answer: @entity2


abstract: In recent years several different tests of cations in @entity0 cells have been studied to detect and to define possible roles in the development of essential @entity1 . The goal of this report is to summarize what has been learned in genetic and epidemiological studies of @entity0 populations. The seven tests reviewed in greatest detail include @entity5 - @entity4 countertransport, intraerythrocytic @entity5 , @entity5 (or @entity4 )- @entity3 cotransport, @entity4 leak, @entity5 - @entity3 ATPase pump, @entity5 pump sites (ouabain binding), and circulating @entity5 pump inhibitor ('digoxin-like factor' in some studies). Countertransport, intraerythrocytic @entity5 and cotransport consistently show different values in @entity1 compared to normotensives and even in normotensives with a positive family history of @entity1 when compared to controls without a positive family history. Thorough genetic studies have been carried out only for @entity5 - @entity4 countertransport and intraerythrocytic @entity5 . Both of these tests are highly heritable with a combination of both polygenic and major gene effects. Cotransport, leak, and pump sites also seem to be quite significantly heritable whereas the ATPase pump activity and the circulating pump inhibitor seem to be largely determined by nongenetic factors. Some of the most dramatic changes in these tests have been observed during pregnancy. Significant increases are seen in countertransport, cotransport, ouabain binding sites, and digoxin-like factor. Oral contraceptives also seem to affect at least cotransport. Plasma @entity2 level and body weight are some of the strongest correlates of countertransport, cotransport, and @entity4 leak. Cotransport increases with higher dietary @entity5 intake and decreases with the use of the diuretic medication. In the current developmental stage these tests have several significant limitations. In most population studies there is a considerable overlap of test values between @entity0 with high and normal blood pressure. There are substantial variations in the methods used by different laboratories for the same tests. They are expensive, complex and usually must be done on fresh cells. There are conflicts between the results of several different reported studies that could be due to the way in which their subjects were selected, the effects of medications or other uncontrolled variables, or even due to the differences in laboratory methodologies.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Genetic and epidemiological studies on electrolyte transport systems in XXXX .

answer: @entity1


abstract: @entity2 constitute a number of diverse neoplastic lesions located within 2   cm of the major @entity5 ; among these, metastatic lesions account for only a small proportion of the periampullary @entity2 . To our knowledge, a metastatic @entity2 from @entity3 has never been reported. A 62-year-old male reported to our institute for fatigue and low hemoglobin. His medical history was remarkable for multifocal @entity3 ( @entity3 ) treated with selective transcatheter arterial chemoembolization (TACE). An esophagogastroduodenoscopy (EGD) was performed which revealed a periampullary mass. Histopathology was consistent with metastatic moderately differentiated @entity3 . Two endoloops were deployed around the base of the mass one month apart. The mass eventually sloughed off and @entity0 's hemoglobin level stabilized. We postulated that periampullary @entity1 in this @entity0 was the result of @entity2 fragments migration through the biliary tracts and that TACE which increases @entity2 fragments burden might have played a contributory role. @entity1 of @entity3 to the gastrointestinal (GI) tract should be considered as a cause of @entity4 .

title: Metastatic Periampullary Tumor from @entity3 Presenting as XXXX .

answer: @entity4


abstract: @entity2 constitute a number of diverse neoplastic lesions located within 2   cm of the major @entity5 ; among these, metastatic lesions account for only a small proportion of the periampullary @entity2 . To our knowledge, a metastatic @entity2 from @entity3 has never been reported. A 62-year-old male reported to our institute for fatigue and low hemoglobin. His medical history was remarkable for multifocal @entity3 ( @entity3 ) treated with selective transcatheter arterial chemoembolization (TACE). An esophagogastroduodenoscopy (EGD) was performed which revealed a periampullary mass. Histopathology was consistent with metastatic moderately differentiated @entity3 . Two endoloops were deployed around the base of the mass one month apart. The mass eventually sloughed off and @entity0 's hemoglobin level stabilized. We postulated that periampullary @entity1 in this @entity0 was the result of @entity2 fragments migration through the biliary tracts and that TACE which increases @entity2 fragments burden might have played a contributory role. @entity1 of @entity3 to the gastrointestinal (GI) tract should be considered as a cause of @entity4 .

title: Metastatic Periampullary Tumor from XXXX Presenting as @entity4 .

answer: @entity3


abstract: The influence of previous antibiotic therapy on the aerobic faecal flora, including P-fimbriated @entity1 , was studied in 953 neonates at discharge from 22 neonatal wards in Sweden. Antibiotics, mainly @entity4 (with or without @entity3 ) or @entity5 , had been received by 37% of the @entity0 . Treatment with @entity4 (with or without @entity3 ) increased @entity6 /Enterobacter and reduced Esch. coli colonization. Cephalosporin therapy (71% @entity5 ) reduced the frequency of colonization with both Esch. coli and @entity6 /Enterobacter spp. but doubled the isolation rate of other Gram-negative bacteria (Citrobacter, Pseudomonas, @entity2 spp.) and tripled the incidence of specimens yielding no aerobic Gram-negative growth. @entity3 showed no significant ecological impact. The selection of @entity6 /Enterobacter and P-negative Esch. coli strains by @entity4 was correlated with their resistance to this agent, while the association between P-fimbriated Esch. coli and @entity5 therapy was not related to @entity5 resistance.

title: Influence of antibiotic therapy on faecal carriage of P-fimbriated XXXX and other gram-negative bacteria in neonates.

answer: @entity1


abstract: There have been several causes of @entity2 attributed to gamete quality, congenital anatomical @entity1 . Published research into the reasons for failure of implantation of embryos has been confined to histochemical and histological studies of the endometrium. This paper presents preliminary data from an ongoing study to test the hypothesis that poor uterine perfusion is a cause of failure of implantation of embryos. It would follow that poor uterine perfusion is a cause of @entity2 . One-hundred-and-fifty-three @entity0 who had been unsuccessful in conceiving despite three previous in-vitro fertilization attempts have been studied. Doppler ultrasound studies of the ascending branch of the uterine artery, during spontaneous ovarian cycles, revealed a poor mid-secretory uterine response in 48% of @entity0 studied. @entity0 with poor mid-secretory uterine response were treated with orally administered hormone therapy to improve the mid-secretory uterine response prior to subsequent embryo replacement. The results of subsequent in-vitro fertilization therapy in @entity0 with good uterine response and in @entity0 with improved uterine response after hormone therapy are presented. The numbers of @entity0 in each group are insufficient for statistical analyses, but the trends observed support the hypothesis that poor uterine blood flow is a cause of @entity2 . Further evaluation is warranted.

title: Decreased uterine perfusion--a cause of XXXX .

answer: @entity2


abstract: Aim. To report a case of bilateral Sturge-Weber and @entity10 with @entity4 in a @entity0 . Method. CASE REPORT: Results. A 4-year-old male @entity0 was referred to us for control of intraocular pressure (IOP). Sleeping IOP was 36   mm   Hg in right eye and 28   mm   Hg in the left eye. The sclera of both the eyes showed bluish black @entity6 . Fundus examination of both eyes showed diffuse @entity8 with glaucomatous cupping. @entity9 was present on both sides of face along all the 3 divisions of trigeminal nerve with overlying @entity5 of skin and on left forearm. Nevus fuscocaeruleus was present on upper trunk. All @entity3 were present since birth and were stationary in nature. CT scan of head revealed left-sided @entity2 . Intraocular pressure was controlled after treatment with topical antiglaucoma medications. Pulsed Dye Laser has been advised by dermatologist for @entity3 . @entity0 has been advised for regular follow-up. Conclusion. The two overlapping @entity1 and their association with @entity4 are a rare entity. Management should be targeted both for @entity7 .

title: Bilateral Sturge-Weber and XXXX with @entity4 , an Overlap Syndrome.

answer: @entity10


abstract: Aim. To report a case of bilateral Sturge-Weber and @entity10 with @entity4 in a @entity0 . Method. CASE REPORT: Results. A 4-year-old male @entity0 was referred to us for control of intraocular pressure (IOP). Sleeping IOP was 36   mm   Hg in right eye and 28   mm   Hg in the left eye. The sclera of both the eyes showed bluish black @entity6 . Fundus examination of both eyes showed diffuse @entity8 with glaucomatous cupping. @entity9 was present on both sides of face along all the 3 divisions of trigeminal nerve with overlying @entity5 of skin and on left forearm. Nevus fuscocaeruleus was present on upper trunk. All @entity3 were present since birth and were stationary in nature. CT scan of head revealed left-sided @entity2 . Intraocular pressure was controlled after treatment with topical antiglaucoma medications. Pulsed Dye Laser has been advised by dermatologist for @entity3 . @entity0 has been advised for regular follow-up. Conclusion. The two overlapping @entity1 and their association with @entity4 are a rare entity. Management should be targeted both for @entity7 .

title: Bilateral Sturge-Weber and @entity10 with XXXX , an Overlap Syndrome.

answer: @entity4


abstract: In order to objectively evaluate the effectiveness, safety and usefulness of the new oral cephem @entity4 proxetil ( @entity2 , CPDX-PR) for the treatment of @entity3 , a double-blind comparative study was undertaken using cefaclor (CCL) as the control drug. CPDX-PR and CCL were administered for 7 days at daily doses of 400 mg (divided into 2 portions) and 750 mg (divided into 3 portions), respectively. A total of 243 @entity0 (118 in the CPDX-PR group and 125 in the CCL group) was treated in this study. The effectiveness, safety and usefulness were evaluated in 222 (106 in the CPDX-PR group and 116 in the CCL group), 234 (113 in the CPDX-PR group and 121 in the CCL group) and in 223 @entity0 (107 in the CPDX-PR group and 116 in the CCL group), respectively. There were no differences in @entity0 ' backgrounds between the 2 groups, except for the presence or the absence of surgical treatments. The results we obtained are summarized below: 1. In the evaluation of clinical efficacy by the subcommittee, excellent, good, fair and poor efficacy were observed in 36, 43, 17 and 10 @entity0 in the CPDX-PR group, respectively; the efficacy rate was, therefore, calculated to be 74.5%. As for the @entity5 group, respective results were observed in 50, 39, 17 and 10 @entity0 , indicating an efficacy rate of 76.7%. There was no significant difference between the 2 groups. Improvement rates judged by physicians in charge were 80.2% in the CPDX-PR group and 88.8% in the CCL group. Moreover, no significant difference in diseases or severity were found between the 2 groups. 2. As for the bacteriological efficacy, the 2 groups showed high elimination rates, as 90.1% and 91.6% of the disease causing bacteria were eliminated in the CPDX-PR group and in the CCL group, respectively. Elimination rates in single infections with @entity1 were determined to be 85.7% in the CPDX-PR group and 85.0% in the CCL group. 3. Although 6 @entity0 in the CPDX-PR group and 2 @entity0 in the CCL group developed side effects, which were mainly gastrointestinal symptoms, there was no significant difference in the incidence of side effects between the 2 groups. Abnormal laboratory values were found in 5 @entity0 in the CPDX-PR group and 1 @entity0 in the CCL group. 4. There was no significant difference in the usefulness between the 2 groups.(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Clinical evaluation of XXXX proxetil in the treatment of @entity3 . A double blind comparison of @entity4 proxetil and cefaclor].

answer: @entity4


abstract: In order to objectively evaluate the effectiveness, safety and usefulness of the new oral cephem @entity4 proxetil ( @entity2 , CPDX-PR) for the treatment of @entity3 , a double-blind comparative study was undertaken using cefaclor (CCL) as the control drug. CPDX-PR and CCL were administered for 7 days at daily doses of 400 mg (divided into 2 portions) and 750 mg (divided into 3 portions), respectively. A total of 243 @entity0 (118 in the CPDX-PR group and 125 in the CCL group) was treated in this study. The effectiveness, safety and usefulness were evaluated in 222 (106 in the CPDX-PR group and 116 in the CCL group), 234 (113 in the CPDX-PR group and 121 in the CCL group) and in 223 @entity0 (107 in the CPDX-PR group and 116 in the CCL group), respectively. There were no differences in @entity0 ' backgrounds between the 2 groups, except for the presence or the absence of surgical treatments. The results we obtained are summarized below: 1. In the evaluation of clinical efficacy by the subcommittee, excellent, good, fair and poor efficacy were observed in 36, 43, 17 and 10 @entity0 in the CPDX-PR group, respectively; the efficacy rate was, therefore, calculated to be 74.5%. As for the @entity5 group, respective results were observed in 50, 39, 17 and 10 @entity0 , indicating an efficacy rate of 76.7%. There was no significant difference between the 2 groups. Improvement rates judged by physicians in charge were 80.2% in the CPDX-PR group and 88.8% in the CCL group. Moreover, no significant difference in diseases or severity were found between the 2 groups. 2. As for the bacteriological efficacy, the 2 groups showed high elimination rates, as 90.1% and 91.6% of the disease causing bacteria were eliminated in the CPDX-PR group and in the CCL group, respectively. Elimination rates in single infections with @entity1 were determined to be 85.7% in the CPDX-PR group and 85.0% in the CCL group. 3. Although 6 @entity0 in the CPDX-PR group and 2 @entity0 in the CCL group developed side effects, which were mainly gastrointestinal symptoms, there was no significant difference in the incidence of side effects between the 2 groups. Abnormal laboratory values were found in 5 @entity0 in the CPDX-PR group and 1 @entity0 in the CCL group. 4. There was no significant difference in the usefulness between the 2 groups.(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Clinical evaluation of @entity4 proxetil in the treatment of @entity3 . A double blind comparison of XXXX proxetil and cefaclor].

answer: @entity4


abstract: In order to objectively evaluate the effectiveness, safety and usefulness of the new oral cephem @entity4 proxetil ( @entity2 , CPDX-PR) for the treatment of @entity3 , a double-blind comparative study was undertaken using cefaclor (CCL) as the control drug. CPDX-PR and CCL were administered for 7 days at daily doses of 400 mg (divided into 2 portions) and 750 mg (divided into 3 portions), respectively. A total of 243 @entity0 (118 in the CPDX-PR group and 125 in the CCL group) was treated in this study. The effectiveness, safety and usefulness were evaluated in 222 (106 in the CPDX-PR group and 116 in the CCL group), 234 (113 in the CPDX-PR group and 121 in the CCL group) and in 223 @entity0 (107 in the CPDX-PR group and 116 in the CCL group), respectively. There were no differences in @entity0 ' backgrounds between the 2 groups, except for the presence or the absence of surgical treatments. The results we obtained are summarized below: 1. In the evaluation of clinical efficacy by the subcommittee, excellent, good, fair and poor efficacy were observed in 36, 43, 17 and 10 @entity0 in the CPDX-PR group, respectively; the efficacy rate was, therefore, calculated to be 74.5%. As for the @entity5 group, respective results were observed in 50, 39, 17 and 10 @entity0 , indicating an efficacy rate of 76.7%. There was no significant difference between the 2 groups. Improvement rates judged by physicians in charge were 80.2% in the CPDX-PR group and 88.8% in the CCL group. Moreover, no significant difference in diseases or severity were found between the 2 groups. 2. As for the bacteriological efficacy, the 2 groups showed high elimination rates, as 90.1% and 91.6% of the disease causing bacteria were eliminated in the CPDX-PR group and in the CCL group, respectively. Elimination rates in single infections with @entity1 were determined to be 85.7% in the CPDX-PR group and 85.0% in the CCL group. 3. Although 6 @entity0 in the CPDX-PR group and 2 @entity0 in the CCL group developed side effects, which were mainly gastrointestinal symptoms, there was no significant difference in the incidence of side effects between the 2 groups. Abnormal laboratory values were found in 5 @entity0 in the CPDX-PR group and 1 @entity0 in the CCL group. 4. There was no significant difference in the usefulness between the 2 groups.(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Clinical evaluation of @entity4 proxetil in the treatment of XXXX . A double blind comparison of @entity4 proxetil and cefaclor].

answer: @entity3


abstract: @entity5 ( @entity5 ) is a @entity3 with a poor prognosis and is characterized by the accumulation of fibrotic tissue in lungs resulting from a dysfunction in the healing process. In @entity0 , the pathological process is patchy and temporally heterogeneous and the exact mechanisms remain poorly understood. Different animal models were thus developed. Among these, intratracheal administration of @entity4 (BML) is one of the most frequently used methods to induce @entity2 in rodents. In the present study, we first characterized histologically the time-course of lung alteration in @entity1 submitted to BLM instillation. Heterogeneous damages were observed among lungs, consisting in an inflammatory phase at early time-points. It was followed by a transition to a fibrotic state characterized by an increased myofibroblast number and collagen accumulation. We then compared instillation and aerosolization routes of BLM administration. The fibrotic process was studied in each pulmonary lobe using a modified Ashcroft scale. The two quantification methods were confronted and the interobserver variability evaluated. Both methods induced @entity2 development as demonstrated by a similar progression of the highest modified Ashcroft score. However, we highlighted that aerosolization allows a more homogeneous distribution of lesions among lungs, with a persistence of higher grade damages upon time.

title: Intratracheal XXXX Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis @entity1 Model?

answer: @entity4


abstract: @entity5 ( @entity5 ) is a @entity3 with a poor prognosis and is characterized by the accumulation of fibrotic tissue in lungs resulting from a dysfunction in the healing process. In @entity0 , the pathological process is patchy and temporally heterogeneous and the exact mechanisms remain poorly understood. Different animal models were thus developed. Among these, intratracheal administration of @entity4 (BML) is one of the most frequently used methods to induce @entity2 in rodents. In the present study, we first characterized histologically the time-course of lung alteration in @entity1 submitted to BLM instillation. Heterogeneous damages were observed among lungs, consisting in an inflammatory phase at early time-points. It was followed by a transition to a fibrotic state characterized by an increased myofibroblast number and collagen accumulation. We then compared instillation and aerosolization routes of BLM administration. The fibrotic process was studied in each pulmonary lobe using a modified Ashcroft scale. The two quantification methods were confronted and the interobserver variability evaluated. Both methods induced @entity2 development as demonstrated by a similar progression of the highest modified Ashcroft score. However, we highlighted that aerosolization allows a more homogeneous distribution of lesions among lungs, with a persistence of higher grade damages upon time.

title: Intratracheal @entity4 Aerosolization: The Best Route of Administration for a Scalable and Homogeneous Pulmonary Fibrosis XXXX Model?

answer: @entity1


abstract: BACKGROUND: Grass pollen, in particular from Lolium multiflorum is a major allergen source in temperate climate zones of Southern Brazil. The IgE sensitization profile of Brazilian grass pollen @entity1 @entity0 to individual allergen molecules has not been analyzed yet. OBJECTIVE: To analyze the IgE sensitization profile of a Brazilian grass pollen @entity1 population using individual allergen molecules. METHODS: We analyzed sera from 78 grass pollen @entity1 @entity0 for the presence of IgE antibodies specific for 103 purified micro-arrayed natural and recombinant allergens by chip technology. IgE-ELISA inhibition experiments with Lolium multiflorum, Phleum pratense extracts and a recombinant fusion protein consisting of Phl p 1, Phl p 2, Phl p 5 and Phl p 6 were performed to investigate cross-reactivities. RESULTS: Within the Brazilian grass pollen @entity1 @entity0 , the most frequently recognized allergens were Phl p 1 (95%), Phl p 5 (82%), Phl p 2 (76%) followed by Phl p 4 (64%), Phl p 6 (45%), Phl p 11 (18%) and Phl p 12 (18%). Most @entity0 were sensitized only to grass pollen allergens but not to allergens from other sources. A high degree of IgE cross-reactivity between Phleum pratense, Lolium multiflorum and the recombinant timothy grass fusion protein was found. CONCLUSIONS: Component-resolved analysis of sera from Brazilian grass pollen @entity1 @entity0 reveals an IgE recognition profile compatible with a typical Pooideae sensitization. The high degree of cross-reactivity between Phleum pratense and Lolium multiflorum allergens suggests that diagnosis and immunotherapy can be achieved with timothy grass pollen allergens in the studied population.

title: Allergen Microarray Indicates Pooideae Sensitization in Brazilian Grass Pollen Allergic XXXX .

answer: @entity0


abstract: BACKGROUND: There are several publications reported that @entity1 ( @entity1 ) was associated with @entity3 . However, large-scaled, population-based cohort study has been limited. We aimed to examine the risk of @entity1 among adult @entity0 with @entity3 in an Asian population. METHODS: We conducted a retrospective cohort study using data from the National Health Insurance (NHI) of Taiwan. The @entity3 cohort included 38,840 newly diagnosed @entity0 between 2000 and 2010. The date of diagnosis was defined as the index date. Each @entity0 was randomly matched with four @entity0 without @entity3 according to gender, age, and the index year as the comparison cohort. The occurrence of @entity1 was followed up until the end of 2011. The risk of @entity1 was estimated using the Cox proportional hazard model after adjusting for gender, age, and comorbidities. RESULTS: The overall incidence of @entity1 was 2.51-fold greater in the @entity3 cohort than in the comparison cohort (12.1 versus 4.84 per 1000 @entity0 -years). Compared to non- @entity3 subjects, the adjusted hazard ratio (aHR) of @entity1 increased to 1.78 for @entity3 @entity0 with one or less annual emergency room (ER) visit, and 23.8 for those who visited ER more than once per year. In addition, aHR in @entity0 with inhaled @entity2 treatment compared to those without @entity2 treatment was 1.33 (95% CI = 1.01-1.76). CONCLUSION: @entity0 with @entity3 have a significantly higher risk of developing @entity1 than the general population. The results suggest that the risk of @entity1 is proportional to @entity3 control and @entity0 with inhaled @entity2 treatment have a higher risk for @entity1 than those without @entity2 treatment.

title: Risk of Obstructive Sleep Apnea in Adult @entity0 with XXXX : A Population-Based Cohort Study in Taiwan.

answer: @entity3


abstract: BACKGROUND: There are several publications reported that @entity1 ( @entity1 ) was associated with @entity3 . However, large-scaled, population-based cohort study has been limited. We aimed to examine the risk of @entity1 among adult @entity0 with @entity3 in an Asian population. METHODS: We conducted a retrospective cohort study using data from the National Health Insurance (NHI) of Taiwan. The @entity3 cohort included 38,840 newly diagnosed @entity0 between 2000 and 2010. The date of diagnosis was defined as the index date. Each @entity0 was randomly matched with four @entity0 without @entity3 according to gender, age, and the index year as the comparison cohort. The occurrence of @entity1 was followed up until the end of 2011. The risk of @entity1 was estimated using the Cox proportional hazard model after adjusting for gender, age, and comorbidities. RESULTS: The overall incidence of @entity1 was 2.51-fold greater in the @entity3 cohort than in the comparison cohort (12.1 versus 4.84 per 1000 @entity0 -years). Compared to non- @entity3 subjects, the adjusted hazard ratio (aHR) of @entity1 increased to 1.78 for @entity3 @entity0 with one or less annual emergency room (ER) visit, and 23.8 for those who visited ER more than once per year. In addition, aHR in @entity0 with inhaled @entity2 treatment compared to those without @entity2 treatment was 1.33 (95% CI = 1.01-1.76). CONCLUSION: @entity0 with @entity3 have a significantly higher risk of developing @entity1 than the general population. The results suggest that the risk of @entity1 is proportional to @entity3 control and @entity0 with inhaled @entity2 treatment have a higher risk for @entity1 than those without @entity2 treatment.

title: Risk of Obstructive Sleep Apnea in Adult XXXX with @entity3 : A Population-Based Cohort Study in Taiwan.

answer: @entity0


abstract: BACKGROUND: The overall incidence of poor ovarian response in IVF cycles has been reported to be between 9 and 24  %. The management of these @entity0 remains a significant challenge in assisted reproduction. The aim of the present study was to evaluate the effect of @entity3 (MI) on ovarian function in poor responders undergoing ICSI. METHODS: The study is a prospective controlled observational trial, that involved 72 poor responders included in an ICSI program and divided into two groups; group A: 38 @entity0 who have been assuming MI (4  g)   +   @entity2 (FA) (400   g) for the previous 3  months before the enrollment day; group B: 38 @entity0 assuming FA (400   g) alone for the same period. COH was carried out in the same manner in the two groups. The main goal was the assessment of oocytes retrieved number and quality; secondary endpoints were the Ovarian Sensitivity Index (OSI: n   oocytes retrieved/total Gonadotropins units   *   1000), @entity1 levels on the day of hGC, fertilization rate, implantation rate, ongoing pregnancy rate. RESULTS: There was no significant difference between the two groups regarding @entity1 level, but total rec-FSH units were significantly lower (p   =   0.004) and M2 oocytes rate significantly higer (p   =   0.01) in group A. The ovarian sensitivity index was higher, reaching a statistical significance (p   <   0.05), in the group of @entity0 pre-treated with MI, showing an improvement in ovarian sensibility to gonadotropin. CONCLUSIONS: Our results suggest that MI therapy in poor responders results in an increased of the number of oocytes recovered in MII and of the gonadotropin Ovarian Sensitivity Index (OSI), suggesting a MI role in improving ovarian response to gonadotropins. Therefore MI seems to be helpful in "poor responders" undergoing IVF cycles.

title: XXXX therapy for poor-responders during IVF: a prospective controlled observational trial.

answer: @entity3


abstract: OBJECTIVES: To investigate the outcome of limited ileo-caecal resection in @entity0 with localised @entity1 ( @entity1 ) and determine predictors of further surgery. METHODS: Review of @entity0 diagnosed with @entity1 and operated on for ileo-caecal disease from 1995 to 2005. Age at diagnosis, endoscopic disease distribution, indication for surgery, site of recurrence and date of last follow-up were recorded. Surgery required removal of only the ileo-caecal junction and caecal pole with removal of the minimum terminal ileal length. RESULTS: Thirty seven @entity0 underwent intestinal resection. Time between primary operation and most recent follow-up was 3.8  years (range 1  month-8.8  years). Indications for surgery were obstruction/stricture (20), treatment-resistant disease (13) and abscess/perforation @entity2 (4). Follow-up was available in 32. Nine (28%) required re-laparotomy. Median time to second laparotomy was 12  months (range 4-58  months). Eighteen @entity0 required no endoscopies after surgery (median follow-up 3.4  years). CONCLUSION: Most conservative surgery occurs about 2  years after diagnosis. About 1 in 4 @entity0 have a further laparotomy within 12  months. Over half of these require division of adhesions. Limited ileo-caecal resection for localized @entity1 is not associated with early peri-anastomotic recurrence. Developments in laparoscopic surgery are likely to further reduce complications from adhesions.

title: Limited ileo-caecal resection for localised XXXX in childhood: Clinical outcome and predictors of further surgery.

answer: @entity1


abstract: The high cost of infliximab inhibits the regular retreatment of all @entity0 in Hungary with @entity1 ( @entity1 ) after beneficial induction therapy. This study is set out to evaluate the medium-term efficacy of induction therapy with infliximab without retreatment in @entity1 @entity0 with chronic activity and/or fistulae refractory to conventional therapy. METHODS: A retrospective 1-year review was undertaken of all @entity1 @entity0 with successfully induced remission or @entity4 closure with 3 infusions of infliximab. Infliximab was administered in a dose of 5  mg/kg 3 times, in weeks 0, 2 and 6. Clinical remission was defined as symptom resolution and an estimated @entity1 Activity Index (CDAI) <150 and complete @entity4 closure. We evaluated the clinical response, the estimated CDAI, the number of draining fistulae, the dosages of @entity3 and immunosuppressive drugs at 6 and 12  months after the last infusion, and the needs for hospitalization and surgical intervention during this period. Breslow (Generalized Wilcoxon) test was used as the statistical method. RESULTS: The data of the 50 @entity0 (19 luminal, 31 fistulizing disease; average age 29. 3 [13-59] years, disease localization: 23 colon, 13 ileum, 13 ileocolon, 1 duodenum) were suitable for analysis. Infliximab induction therapy without retreatment resulted in a beneficial effect lasting for at least 1  year in 22 of the 50 @entity0 (44%). 11 of the 19 @entity0 (57.9%) with @entity2 remained in steroid-free complete remission, while the fistulae persisted closed in only 11 of the 31 @entity0 (35.5%) (p<0.05). CONCLUSION: Infliximab induction therapy alone may result in sustained remission mainly in @entity0 with @entity2 . These results suggest the need for maintenance therapy with infliximab after successful therapy induction in @entity0 with fistulae, while luminal @entity1 @entity0 could possibly participate in regular retreatment only if needed. If these data are confirmed, this modification of the therapeutic procedure could well increase the cost-effectiveness of infliximab.

title: Is the efficacy of successful infliximab induction therapy maintained for one year lasting without retreatment in different behavior types of XXXX ?

answer: @entity1


abstract: BACKGROUND: Corticosteroid therapy for @entity1 ( @entity1 ) frequently results in @entity3 -dependency. The objective of this study was to evaluate the long term clinical and endoscopic efficacy of infliximab (IFX) in @entity3 -dependent @entity1 . METHODS: An open-label, prospective, single center study was designed. @entity0 older than 18  years with @entity3 -dependent @entity1 , either intolerant or did not respond to @entity5 , were consecutively enrolled. @entity3 -dependency was defined as the ECCO criteria. @entity0 received IFX (5  mg/kg) at 0, 2 and 6  weeks and every 8  weeks thereafter for 2  years. All @entity0 were clinically evaluated at weeks 8, 52 and 104 and a colonoscopy was performed at week 104. Response to IFX was defined as clinical remission without @entity4 together with @entity2 (endoscopic Mayo score of 0 or 1). RESULTS: Seventeen consecutive @entity0 were included (11 male, mean age 45, range 25-70). Thirteen (76%) had extensive @entity6 (E3). All @entity0 completed IFX therapy. Clinical response was in 13/17 at weeks 8 and 52. Twelve out of seventeen @entity0 maintained clinical remission without @entity4 and endoscopic response at week 104. Six out of seventeen @entity0 needed dose intensification of IFX (every 6  weeks); 3/6 @entity0 did not reach remission despite dose intensification. Including those @entity0 who needed dose intensification as non-responders, 9/17 @entity0 were in clinical and endoscopic remission at week 104. A significant correlation was found between clinical and endoscopic findings (p<0.01). CONCLUSIONS: Infliximab therapy is effective for maintenance of clinical remission and @entity2 in @entity0 with @entity3 -dependent @entity1 .

title: Mucosal healing and @entity3 -sparing associated with infliximab for @entity3 -dependent XXXX .

answer: @entity1


abstract: BACKGROUND: Corticosteroid therapy for @entity1 ( @entity1 ) frequently results in @entity3 -dependency. The objective of this study was to evaluate the long term clinical and endoscopic efficacy of infliximab (IFX) in @entity3 -dependent @entity1 . METHODS: An open-label, prospective, single center study was designed. @entity0 older than 18  years with @entity3 -dependent @entity1 , either intolerant or did not respond to @entity5 , were consecutively enrolled. @entity3 -dependency was defined as the ECCO criteria. @entity0 received IFX (5  mg/kg) at 0, 2 and 6  weeks and every 8  weeks thereafter for 2  years. All @entity0 were clinically evaluated at weeks 8, 52 and 104 and a colonoscopy was performed at week 104. Response to IFX was defined as clinical remission without @entity4 together with @entity2 (endoscopic Mayo score of 0 or 1). RESULTS: Seventeen consecutive @entity0 were included (11 male, mean age 45, range 25-70). Thirteen (76%) had extensive @entity6 (E3). All @entity0 completed IFX therapy. Clinical response was in 13/17 at weeks 8 and 52. Twelve out of seventeen @entity0 maintained clinical remission without @entity4 and endoscopic response at week 104. Six out of seventeen @entity0 needed dose intensification of IFX (every 6  weeks); 3/6 @entity0 did not reach remission despite dose intensification. Including those @entity0 who needed dose intensification as non-responders, 9/17 @entity0 were in clinical and endoscopic remission at week 104. A significant correlation was found between clinical and endoscopic findings (p<0.01). CONCLUSIONS: Infliximab therapy is effective for maintenance of clinical remission and @entity2 in @entity0 with @entity3 -dependent @entity1 .

title: Mucosal healing and XXXX -sparing associated with infliximab for @entity3 -dependent @entity1 .

answer: @entity3


abstract: BACKGROUND: Corticosteroid therapy for @entity1 ( @entity1 ) frequently results in @entity3 -dependency. The objective of this study was to evaluate the long term clinical and endoscopic efficacy of infliximab (IFX) in @entity3 -dependent @entity1 . METHODS: An open-label, prospective, single center study was designed. @entity0 older than 18  years with @entity3 -dependent @entity1 , either intolerant or did not respond to @entity5 , were consecutively enrolled. @entity3 -dependency was defined as the ECCO criteria. @entity0 received IFX (5  mg/kg) at 0, 2 and 6  weeks and every 8  weeks thereafter for 2  years. All @entity0 were clinically evaluated at weeks 8, 52 and 104 and a colonoscopy was performed at week 104. Response to IFX was defined as clinical remission without @entity4 together with @entity2 (endoscopic Mayo score of 0 or 1). RESULTS: Seventeen consecutive @entity0 were included (11 male, mean age 45, range 25-70). Thirteen (76%) had extensive @entity6 (E3). All @entity0 completed IFX therapy. Clinical response was in 13/17 at weeks 8 and 52. Twelve out of seventeen @entity0 maintained clinical remission without @entity4 and endoscopic response at week 104. Six out of seventeen @entity0 needed dose intensification of IFX (every 6  weeks); 3/6 @entity0 did not reach remission despite dose intensification. Including those @entity0 who needed dose intensification as non-responders, 9/17 @entity0 were in clinical and endoscopic remission at week 104. A significant correlation was found between clinical and endoscopic findings (p<0.01). CONCLUSIONS: Infliximab therapy is effective for maintenance of clinical remission and @entity2 in @entity0 with @entity3 -dependent @entity1 .

title: Mucosal healing and @entity3 -sparing associated with infliximab for XXXX -dependent @entity1 .

answer: @entity3


abstract: BACKGROUND: We analyzed the potential of endovascular stent grafts to treat late @entity6 after @entity4 repair. METHODS: Eight @entity0 (7 male; age 28 to 58, mean 43 years) presented with @entity6 after primary repair performed at the age of 5 to 27 (mean 12) years; 2 @entity0 had @entity1 with @entity3 . The mean interval between the procedures was 31 (19 to 42) years; one @entity0 had 3 previous operations. This subset represents 2.2% of our overall experience in @entity5 repair (n=368). @entity5 endografts were implanted using the transfemoral technique. Custom-made reverse tapered stent grafts were used in 4 cases. The left subclavian artery (LSA) was covered in 5 @entity0 . Protective transposition of the left subclavian artery was performed in 4 @entity0 . RESULTS: Hospital mortality was 12.5%; 1 @entity0 died from secondary @entity1 after emergency repair. Primary complete exclusion of the @entity2 was achieved in 6 @entity0 . Secondary exclusion after implantation of a second stent graft was successful in the second @entity1 @entity0 . No endoleak was present at discharge. All discharged @entity0 are alive after 8 to 63 (mean 36) months. Follow-up computed tomography or transesophageal echocardiography revealed no secondary endoleaks or late expansion. The @entity6 had shrunk completely in 3 @entity0 , were reduced in size in 2 @entity0 , and remained unchanged in 2 @entity0 . No late secondary interventions were noted. CONCLUSIONS: Single piece, reversed, tapered stent grafts adapt better to the special anatomy of the hypoplastic aortic arch. Midterm results are excellent; complete shrinkage in 50% is remarkable. However, the long-term behavior of these implants in young @entity0 requires further evaluation and surveillance.

title: Endovascular stent-graft repair of late @entity6 after surgery for XXXX .

answer: @entity4


abstract: BACKGROUND: We analyzed the potential of endovascular stent grafts to treat late @entity6 after @entity4 repair. METHODS: Eight @entity0 (7 male; age 28 to 58, mean 43 years) presented with @entity6 after primary repair performed at the age of 5 to 27 (mean 12) years; 2 @entity0 had @entity1 with @entity3 . The mean interval between the procedures was 31 (19 to 42) years; one @entity0 had 3 previous operations. This subset represents 2.2% of our overall experience in @entity5 repair (n=368). @entity5 endografts were implanted using the transfemoral technique. Custom-made reverse tapered stent grafts were used in 4 cases. The left subclavian artery (LSA) was covered in 5 @entity0 . Protective transposition of the left subclavian artery was performed in 4 @entity0 . RESULTS: Hospital mortality was 12.5%; 1 @entity0 died from secondary @entity1 after emergency repair. Primary complete exclusion of the @entity2 was achieved in 6 @entity0 . Secondary exclusion after implantation of a second stent graft was successful in the second @entity1 @entity0 . No endoleak was present at discharge. All discharged @entity0 are alive after 8 to 63 (mean 36) months. Follow-up computed tomography or transesophageal echocardiography revealed no secondary endoleaks or late expansion. The @entity6 had shrunk completely in 3 @entity0 , were reduced in size in 2 @entity0 , and remained unchanged in 2 @entity0 . No late secondary interventions were noted. CONCLUSIONS: Single piece, reversed, tapered stent grafts adapt better to the special anatomy of the hypoplastic aortic arch. Midterm results are excellent; complete shrinkage in 50% is remarkable. However, the long-term behavior of these implants in young @entity0 requires further evaluation and surveillance.

title: Endovascular stent-graft repair of late XXXX after surgery for @entity4 .

answer: @entity6


abstract: @entity1 is a multifactorial, @entity0 . The molecular mechanisms that underlie the pathophysiological changes in @entity2 , especially at the early stage of the disease, are poorly understood. Here, we report the findings from a quantitative proteomic analysis of retinas from experimental @entity1 (EG) eyes. An early stage of EG was modeled on unilateral eyes of five nonhuman primates (NHP) by laser treatment-induced elevation of intraocular pressure (IOP). Retinal proteins were extracted from individual EG eyes and their contralateral control eyes of the same animals, respectively, and analyzed by quantitative mass spectrometry (MS). As a result, a total, 475 retinal proteins were confidently identified and quantified. Results of bioinformatic analysis of proteins that showed an increase in the EG eyes suggested changes in apoptosis, DNA damage, immune response, cytoskeleton rearrangement and cell adhesion processes. Interestingly, hemoglobin subunit alpha ( @entity4 ) and Ras related C3 botulinum toxin substrate 1 ( @entity3 ) were among the increased proteins. Results of molecular modeling of @entity4 - and @entity3 -associated signaling network implicated the involvement of Mitogen-Activated Protein Kinase (MAPK) pathway in the EG, through which @entity3 may exert a regulatory role on @entity4 . This is the first observation of this potentially novel signaling network in the NHP retina and in EG. Results of Western blot analyses for @entity3 , @entity4 and a selected MAPK pathway protein indicated synergistic changes in all three proteins in the EG eyes. Further, results of hierarchical cluster analysis of proteomes of control eyes revealed a clear age-proteome relationship, and such relationship appeared disrupted in the EG eyes. In conclusion, our results suggested an increased presence of a potentially novel signaling network at the early stage of @entity1 , and age might be one of the determinant factors in retinal proteomic characteristics under normal conditions.

title: Alterations in molecular pathways in the retina of early experimental XXXX eyes.

answer: @entity1


abstract: BACKGROUND: Treatments and organizational changes supported by eHealth are beginning to play an important role in improving disease treatment outcome and providing cost-efficient care management. "Improvehealth.eu" is a novel eHealth service to support the treatment of @entity0 with @entity1 . It offers active @entity0 engagement and collaborative care management by combining Web- and mobile-based information and communication technology systems and access to care managers. OBJECTIVES: Our objective was to assess the feasibility of a novel eHealth service. METHODS: The intervention--the "Improvehealth.eu" service--was explored in the course of a pilot study comparing two groups of @entity0 receiving treatment as usual and treatment as usual with eHealth intervention. We compared @entity0 ' medication adherence and outcome measures between both groups and additionally explored usage and overall perceptions of the intervention in intervention group. RESULTS: The intervention was successfully implemented in a pilot with 46 @entity0 , of whom 40 were female. Of the 46 @entity0 , 25 received treatment as usual, and 21 received the intervention in addition to treatment as usual. A total of 55% (12/25) of @entity0 in the former group and 45% (10/21) in the latter group finished the 6-month pilot. Available case analysis indicated an improvement of adherence in the intervention group (odds ratio [OR] = 10.0, P = .03). Intention-to-treat analysis indicated an improvement of outcome in the intervention group (ORs ranging from 0.35 to 18; P values ranging from .003 to .20), but confidence intervals were large due to small sample sizes. Average duration of use of the intervention was 107 days. The intervention was well received by 81% (17/21) of @entity0 who reported feeling actively engaged, in control of their disease, and that they had access to a high level of information. In all, 33% (7/21) of the @entity0 also described drawbacks of the intervention, mostly related to usability issues. CONCLUSIONS: The results of this pilot study indicate that the intervention was well accepted and helped the @entity0 in the course of treatment. The results also suggest the potential of the intervention to improve both medication adherence and outcome measures of treatment, including reduction of @entity1 severity and @entity0 becoming "healthy."

title: Feasibility of an eHealth service to support collaborative XXXX care: results of a pilot study.

answer: @entity1


abstract: PURPOSE: To examine the association of quality of life (QOL) after diagnosis of @entity0 with mortality and recurrence. @entity1 AND METHODS: From 2002 to 2004, a total of 2,230 @entity0 survivors completed the General Quality of Life Inventory-74 6 months after diagnosis as part of the Shanghai @entity0 Survivor Study. Also collected at baseline was information on demographic and clinical characteristics. At 36 months postdiagnosis, 1,845 of these @entity1 were re-evaluated for QOL. Outcomes were ascertained by in- @entity1 interview and record linkage to the vital statistics registry. The association of QOL with total mortality and @entity2 recurrence was assessed by using Cox regression analysis. RESULTS: During a median follow-up of 4.8 years after the 6-month postdiagnosis QOL assessment, 284 @entity3 were identified. Recurrence was documented in 267 @entity1 after 108 @entity1 with @entity0 or recurrence before study enrollment were excluded. @entity1 with the highest tertile of social well-being QOL score, compared with those with the lowest score, had a 38% decreased risk of mortality (95% CI, 0.46 to 0.85; P for trend = .002) and a 48% decreased risk of @entity0 recurrence (95% CI, 0.38 to 0.71; P for trend < .001). QOL assessed at 36 months postdiagnosis was not significantly associated with subsequent risk of mortality or recurrence. CONCLUSION: Social well-being in the first year after @entity2 diagnosis is a significant prognostic factor for @entity0 recurrence or mortality, suggesting a possible avenue of intervention by maintaining or enhancing social support for @entity1 soon after their @entity0 diagnosis to improve disease outcomes.

title: Quality of life after XXXX diagnosis and survival.

answer: @entity0


abstract: OBJECTIVE: To determine the cost-effectiveness of treatment with @entity3 compared with placebo for @entity2 in @entity0 with birth weights less than 1250 g, from birth through 18 to 21 months' corrected age. METHODS: We undertook a retrospective economic evaluation of the cost per survivor without @entity1 by using individual- @entity0 data from the @entity3 for @entity2 clinical trial (N = 1869). We included direct medical costs either to the insurance payer or the hospital but excluded costs to parents and society, such as lost productivity. We used a price of  0.21/mg of generic @entity4 for our base-case analysis. All costs were expressed in 2008 Canadian dollars and discounted at 3%. The time horizon for this analysis extended through 18 to 21 months' corrected age to match the clinical trial. RESULTS: The mean cost per @entity0 was  124 466 in the @entity3 group and  133 505 in the placebo group (difference:  9039 [-14 749 to -3375]; adjusted P = .014). Cost-effectiveness analysis showed @entity3 to be a dominant or "win-win" therapy: in >99% of 1000 bootstrap replications of the analysis, @entity3 -treated @entity0 had simultaneously better outcomes and lower mean costs. These results were robust to a 1000% increase in the individual resource items, including the price of @entity4 . CONCLUSIONS: In comparison with placebo, @entity3 therapy for @entity2 in @entity0 weighing less than 1250 g is economically appealing for @entity0 up to 18 to 21 months' corrected age.

title: Economic evaluation of @entity3 for XXXX .

answer: @entity2


abstract: OBJECTIVE: To determine the cost-effectiveness of treatment with @entity3 compared with placebo for @entity2 in @entity0 with birth weights less than 1250 g, from birth through 18 to 21 months' corrected age. METHODS: We undertook a retrospective economic evaluation of the cost per survivor without @entity1 by using individual- @entity0 data from the @entity3 for @entity2 clinical trial (N = 1869). We included direct medical costs either to the insurance payer or the hospital but excluded costs to parents and society, such as lost productivity. We used a price of  0.21/mg of generic @entity4 for our base-case analysis. All costs were expressed in 2008 Canadian dollars and discounted at 3%. The time horizon for this analysis extended through 18 to 21 months' corrected age to match the clinical trial. RESULTS: The mean cost per @entity0 was  124 466 in the @entity3 group and  133 505 in the placebo group (difference:  9039 [-14 749 to -3375]; adjusted P = .014). Cost-effectiveness analysis showed @entity3 to be a dominant or "win-win" therapy: in >99% of 1000 bootstrap replications of the analysis, @entity3 -treated @entity0 had simultaneously better outcomes and lower mean costs. These results were robust to a 1000% increase in the individual resource items, including the price of @entity4 . CONCLUSIONS: In comparison with placebo, @entity3 therapy for @entity2 in @entity0 weighing less than 1250 g is economically appealing for @entity0 up to 18 to 21 months' corrected age.

title: Economic evaluation of XXXX for @entity2 .

answer: @entity3