abstract: Brugada type 1 electrocardiographic (ECG) pattern occurs in 0.2% of Filipinos. A knowledge gap exists on the natural course of asymptomatic @entity0 with Brugada type 1 ECG pattern. Most studies that reported cohort event rates were taken from hospitals or referral centers. This is the first cohort from an entire country where the subjects were selected randomly. The objective of this study was to describe the frequency of @entity1 at 4 and 6 years of 7 @entity0 with Brugada type 1 ECG pattern of 3,907 @entity0 previously screened from the general population of the Philippines during the National Nutrition and Health Survey. Personal interviews at year 4 using a structured questionnaire were conducted by 1 of the investigators. Occurrences of major ( @entity4 , @entity2 , unexplained accidents, @entity3 ) and minor events in subjects and their first- and second-degree relatives were elicited. Six-year follow-up by text messaging was conducted to ascertain vital status and occurrence of @entity1 . All 7 @entity0 with Brugada type 1 ECG pattern were @entity0 . Three of the 7 initially asymptomatic subjects (43%, 95 confidence interval 6 to 80) developed a major @entity1 by the fourth year. Those with events were younger than those without events. All 7 were alive by the sixth year. No additional events were noted between the fourth and sixth years. In conclusion, @entity1 are considerable in initially asymptomatic Filipinos with Brugada type 1 ECG pattern.

title: Frequency of XXXX at four years among initially asymptomatic filipinos with the Brugada type 1 electrocardiographic pattern.

answer: @entity1


abstract: Lipoprotein particles were examined in plasma and ascitic fluid from nine @entity0 (5 males and 4 females) with @entity4 and in plasma from nine control subjects. LDL and HDL fractions were isolated by ultracentrifugation under rate flotation conditions in a @entity7 . LDL size was analysed by non-denaturing @entity6 gradient gel electrophoresis. Plasma lipids in cirrhotic @entity0 were markedly reduced compared to controls. Free @entity2 represented 45.3% of the total @entity2 in plasma and 70.4% of the total @entity2 in the ascitic fluid. The total @entity2 - @entity3 ratio was three times higher in the plasma than in the ascitic fluid of cirrhotic @entity0 . The LDL particles had the same flotation properties in plasma from cirrhotic @entity0 as in that from controls. In cirrhotic @entity0 the IDL concentration was higher than that in controls. In ascitic fluid the LDL particles had a higher flotation rate than in the plasma. The LDL diameter as measured by gradient gel electrophoresis was similar in both plasma and ascitic fluid of the cirrhotic @entity0 as well as in the plasma of controls. In plasma and ascitic fluid of cirrhotic @entity0 only a single HDL subclass (HDL1) could be identified. HDL1 particles had a higher flotation rate than normal HDL particles. The plasma levels of all the apoproteins were reduced in cirrhotic subjects compared to controls, but to a variable degree; while apo CII level in @entity1 represented only 9% of the control level, the @entity5 level represented 77% of the control level.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The lipoprotein composition of plasma and ascitic fluid in XXXX .

answer: @entity4


abstract: Fetuses from linebred lean (L) and @entity0 (O) and reciprocal crossmatings were examined at 110 d of gestation for line, maternal and heterotic effects. There was no significant heterotic effect for any trait measured. A significant maternal effect was observed for adipose tissue @entity4 ( @entity4 ) activity and for serum @entity1 . The enzyme activity and @entity1 concentration were higher in fetuses from O dams than in fetuses from L dams. In a lipid clearance test, no maternal effect was observed for changes in serum concentrations of @entity1 and free @entity3 or in optical density (associated with the disappearance of injected Liposyn). Linebred O fetuses exhibited higher @entity4 activity in both the biceps femoris muscle and sc adipose tissue compared with linebred L fetuses. The @entity4 activity of the adipose tissue was higher than that of the skeletal muscle. The percentage of dry matter, percentage of @entity1 and protein/DNA were higher in the muscle of linebred O fetuses than in that of linebred L fetuses. Based on tissue @entity4 activity and on muscle compositional traits, linebred O fetuses were more mature at 110 d of gestation than were the linebred L fetuses. @entity0 had little detectable influence on fetal development of the @entity2 when measured at 110 d of gestation.

title: Influence of maternal XXXX on fetal development in @entity2 .

answer: @entity0


abstract: Fetuses from linebred lean (L) and @entity0 (O) and reciprocal crossmatings were examined at 110 d of gestation for line, maternal and heterotic effects. There was no significant heterotic effect for any trait measured. A significant maternal effect was observed for adipose tissue @entity4 ( @entity4 ) activity and for serum @entity1 . The enzyme activity and @entity1 concentration were higher in fetuses from O dams than in fetuses from L dams. In a lipid clearance test, no maternal effect was observed for changes in serum concentrations of @entity1 and free @entity3 or in optical density (associated with the disappearance of injected Liposyn). Linebred O fetuses exhibited higher @entity4 activity in both the biceps femoris muscle and sc adipose tissue compared with linebred L fetuses. The @entity4 activity of the adipose tissue was higher than that of the skeletal muscle. The percentage of dry matter, percentage of @entity1 and protein/DNA were higher in the muscle of linebred O fetuses than in that of linebred L fetuses. Based on tissue @entity4 activity and on muscle compositional traits, linebred O fetuses were more mature at 110 d of gestation than were the linebred L fetuses. @entity0 had little detectable influence on fetal development of the @entity2 when measured at 110 d of gestation.

title: Influence of maternal @entity0 on fetal development in XXXX .

answer: @entity2


abstract: Hysterectomies are frequently required operations in gynecology. Several studies have reported an association between premenopausal hysterectomy and the risk of @entity2 . However, the pathophysiological linkages between these two conditions have not been elucidated. In recent years it has been shown that a decrease in plasma fibrinolytic activity is associated with increased risk of @entity4 . Furthermore, it has been known that the uterus is a very finbrinolytic active organ. In the present study we investigated the hypothesis that hysterectomy may lead to a decrease in plasma fibrinolytic activity, and thereby increase the risk for @entity5 . Fibrinolytic parameters of plasma were investigated in 26 @entity0 before and 6 weeks after premenopausal hysterectomy. Euglobulin lysis time (ELT), a global measure of plasma fibrinolytic activity, and the levels of @entity7 (tPA) and @entity8 ( @entity8 ) were not different before and after hysterectomy. The ELT difference before and after @entity3 , which is a good indicator for the risk of @entity4 , was also not significantly changed after hysterectomy. @entity1 -17 beta, @entity6 , LH, FSH and sex hormone binding globulin displayed no significant changes after hysterectomy. Furthermore, the hormone measurements also indicated that the @entity0 were premenopausal. There were no correlations between the hormone values and fibrinolytic parameters. These data indicate that premenopausal hysterectomy does not lead to changes in plasma fibrinolytic activity.

title: Influence of hysterectomy on the fibrinolytic activity of plasma of XXXX with intact ovarian function.

answer: @entity0


abstract: Polyoma virus BK-induced @entity5 is an important cause of morbidity after hematopoietic stem cell transplantation (HSCT). @entity7 have been shown in vitro to inhibit BK viral replication by direct inhibition of the BK-encoded DNA gyrase. We hypothesized that extended prophylaxis with @entity3 may decrease the incidence of severe (grades 3 and 4) @entity8 -associated @entity5 (sBKHC) after HSCT. We retrospectively collected @entity0 and transplant data, as well as incidence of sBKHC, for all consecutive @entity0 undergoing allogeneic HSCT between June 2006 and August 2010 at our institution. Prophylaxis for sBKHC with @entity3 500 mg orally twice daily from day 0 until day 60 had been instituted in March 2009, delimiting a group receiving @entity3 prophylaxis (CP) or no prophylaxis (NP). We compared the cumulative incidence of sBKHC in CP and NP, including death in absence of sBKHC as a competing risk. Ninety-two consecutive @entity0 were included in the analysis, 44 in CP and 48 in NP. Median age of @entity0 was 50 years (range: 19-70), and 47% received a myeloablative conditioning regimen. The cumulative incidence of sBKHC was significantly reduced in CP (2.6% versus 20.9%, P  =  .01). Multivariate Cox regression analysis revealed that assignment to CP and concomitant @entity2 ( @entity2 ) were the only factors independently associated with the occurrence of sBKHC. @entity0 in CP did not experience a higher risk of @entity6 @entity1 and were less likely to develop episodes of @entity4 . @entity3 prophylaxis appears safe and effective in reducing the incidence of severe BKHC after allogeneic HSCT.

title: Efficacy and safety of @entity3 for prophylaxis of @entity8 virus-associated XXXX in allogeneic hematopoietic stem cell transplantation recipients.

answer: @entity5


abstract: Polyoma virus BK-induced @entity5 is an important cause of morbidity after hematopoietic stem cell transplantation (HSCT). @entity7 have been shown in vitro to inhibit BK viral replication by direct inhibition of the BK-encoded DNA gyrase. We hypothesized that extended prophylaxis with @entity3 may decrease the incidence of severe (grades 3 and 4) @entity8 -associated @entity5 (sBKHC) after HSCT. We retrospectively collected @entity0 and transplant data, as well as incidence of sBKHC, for all consecutive @entity0 undergoing allogeneic HSCT between June 2006 and August 2010 at our institution. Prophylaxis for sBKHC with @entity3 500 mg orally twice daily from day 0 until day 60 had been instituted in March 2009, delimiting a group receiving @entity3 prophylaxis (CP) or no prophylaxis (NP). We compared the cumulative incidence of sBKHC in CP and NP, including death in absence of sBKHC as a competing risk. Ninety-two consecutive @entity0 were included in the analysis, 44 in CP and 48 in NP. Median age of @entity0 was 50 years (range: 19-70), and 47% received a myeloablative conditioning regimen. The cumulative incidence of sBKHC was significantly reduced in CP (2.6% versus 20.9%, P  =  .01). Multivariate Cox regression analysis revealed that assignment to CP and concomitant @entity2 ( @entity2 ) were the only factors independently associated with the occurrence of sBKHC. @entity0 in CP did not experience a higher risk of @entity6 @entity1 and were less likely to develop episodes of @entity4 . @entity3 prophylaxis appears safe and effective in reducing the incidence of severe BKHC after allogeneic HSCT.

title: Efficacy and safety of @entity3 for prophylaxis of XXXX virus-associated @entity5 in allogeneic hematopoietic stem cell transplantation recipients.

answer: @entity8


abstract: Polyoma virus BK-induced @entity5 is an important cause of morbidity after hematopoietic stem cell transplantation (HSCT). @entity7 have been shown in vitro to inhibit BK viral replication by direct inhibition of the BK-encoded DNA gyrase. We hypothesized that extended prophylaxis with @entity3 may decrease the incidence of severe (grades 3 and 4) @entity8 -associated @entity5 (sBKHC) after HSCT. We retrospectively collected @entity0 and transplant data, as well as incidence of sBKHC, for all consecutive @entity0 undergoing allogeneic HSCT between June 2006 and August 2010 at our institution. Prophylaxis for sBKHC with @entity3 500 mg orally twice daily from day 0 until day 60 had been instituted in March 2009, delimiting a group receiving @entity3 prophylaxis (CP) or no prophylaxis (NP). We compared the cumulative incidence of sBKHC in CP and NP, including death in absence of sBKHC as a competing risk. Ninety-two consecutive @entity0 were included in the analysis, 44 in CP and 48 in NP. Median age of @entity0 was 50 years (range: 19-70), and 47% received a myeloablative conditioning regimen. The cumulative incidence of sBKHC was significantly reduced in CP (2.6% versus 20.9%, P  =  .01). Multivariate Cox regression analysis revealed that assignment to CP and concomitant @entity2 ( @entity2 ) were the only factors independently associated with the occurrence of sBKHC. @entity0 in CP did not experience a higher risk of @entity6 @entity1 and were less likely to develop episodes of @entity4 . @entity3 prophylaxis appears safe and effective in reducing the incidence of severe BKHC after allogeneic HSCT.

title: Efficacy and safety of XXXX for prophylaxis of @entity8 virus-associated @entity5 in allogeneic hematopoietic stem cell transplantation recipients.

answer: @entity3


abstract: RATIONALE AND OBJECTIVES: A new model was developed to study microcirculation in the intact heart of the anesthetized @entity0 , and the effects of roentgenography and magnetic resonance imaging contrast media were investigated. METHODS: Roentgenography contrast media (600 mg @entity1 /kg), @entity6 (0.25 mmol/kg), or physiological saline were injected intraarterially into anesthetized @entity0 (N = 10) whose chests had been opened in a pressurized container. The effects on arterial and venous vasomotion and microhemodynamics of the capillary network were determined in vivo by combined incidental light-fluoroscopic microscopy using continuous 35-mm cine film and video recordings from 5 minutes before until 20 minutes after injection. The amplitude and frequency spectra were evaluated according to the Prony method and by Fourier analysis. Additionally, the number of perfused vessel bifurcations were counted. RESULTS: @entity6 exhibited no effects on microcirculation, and @entity3 exhibited the largest ones. The deformation of the vasomotion spectrum reached 28%, and bifurcations were reduced by 21%. The effects were reversible within 10 minutes of injection. Iotrolan showed minimal disturbance. The other contrast media ( @entity5 , @entity2 , @entity4 ) fell between these two extremes. CONCLUSION: High-osmolar ionic roentgenography contrast media resulted in a transient deregulation of vasomotion and in a disturbed microcirculation in the @entity0 heart. Isotonic or low-osmolar nonionic roentgenography contrast media or @entity6 did not show this effect or showed it only to a minimal extent.

title: Changes in the microcirculation of the intact XXXX heart after iodinated and gadolinium-containing contrast media.

answer: @entity0


abstract: A temporary cardiovascular stent device by bioabsorbable materials might reduce late stent @entity3 . A water-soluble amphiphilic phospholipid polymer bearing @entity4 groups (PMB30W) was blended with a high-molecular-weight @entity5 ( @entity6 ) to reduce unfavorable tissue responses at the surface. The @entity6 implants and the polymer blend ( @entity6 /PMB30W) implants were inserted into subcutaneous tissues of @entity1 , the infrarenal aorta of @entity1 , and the internal carotid arteries of @entity2 . After 6 months subcutaneous implantation, the @entity6 /PMB30W maintained high density of @entity4 groups on the surface without a significant bioabsorption. After intravascular implantation, the cross-sectional areas of polymer tubing with diameters less than 1.6  mm were histomorphometrically measured. Compared to the @entity6 tubing, the @entity6 /PMB30W tubing significantly reduced the @entity3 formation during 30  d of implantation. @entity0 peripheral blood mononuclear cells were cultured on the @entity6 and the @entity6 /PMB30W to compare inflammatory reactions. Enzyme-linked immunosorbent assay quantified substantially decreased proinflammatory cytokines in the case of the @entity6 /PMB30W. They were almost the same level as the negative controls. Thus, we conclude that the @entity4 groups could reduce tissue responses significantly both in vivo and in vitro, and the @entity6 /PMB30W is a promising material for preparing temporary cardiovascular stent devices.

title: Tissue response to XXXX -based blend with phospholipid polymer for biodegradable cardiovascular stents.

answer: @entity5


abstract: Oxidative modification of DNA, lipids, and proteins occurs as a consequence of reaction with free radicals and activated @entity0 . Oxidative modification of total cellular proteins has been described under many pathologic and experimental conditions, but no specific proteins have been identified as in vivo targets for oxidative modification. Utilizing an immunochemical method for detection of oxidatively modified proteins, we identified a protein in @entity1 liver that was highly oxidized. It was purified to homogeneity and identified as carbonic anhydrase, isozyme III. Its characteristics match those previously described for a protein that was lost during aging of the @entity1 , senescence marker protein-1. @entity3 was purified from @entity1 aged 2, 10, and 18 months, and the proteins were characterized. All three preparations were highly oxidatively modified as assessed by their @entity4 content. The enzyme has three known catalytic activities, and the specific activities for @entity2 hydration and for @entity5 hydrolysis decreased during aging by approximately 30%. However, the third activity, that of a phosphatase, was virtually lost during aging. While the physiologic role of @entity3 is unknown, we suggest that it functions in an oxidizing environment, which leads to its own oxidative modification.

title: XXXX . Oxidative modification in vivo and loss of phosphatase activity during aging.

answer: @entity3


abstract: INTRODUCTION: The exclusion of circulating @entity1 cells (CTCs) that have lost epithelial antigens during the epithelial-to-mesenchymal transition (EMT) process by using @entity4 ( @entity4 ) based capture methods is still a matter of debate. In this study, cells obtained after depletion procedure from blood samples of @entity2 ( @entity2 ) @entity0 were identified based on morphology and characterized with the combination of FISH assessment and immunophenotypic profile. MATERIALS AND METHODS: Five mL blood samples, collected from 55 advanced @entity2 @entity0 , were analyzed by a non- @entity4 -based capture method. After depletion of leukocytes and erythroid cells, the negative fraction was characterized by both FISH using a @entity5 ( @entity5 ) probe and by immunocytochemistry. Thirty healthy donors were also tested. RESULTS: Based on morphology (nuclear dimension >= 10  m, shape and hypercromatic aspect) suspicious circulating cells clearly distinguishable from contaminant leukocytes were observed in 49/55 (89%) @entity2 @entity0 . Thirty-four of the 44 (77%) samples evaluable for @entity5 FISH showed >=  6 @entity5 gene copy number on average per cell. @entity3 expression involved 43% (18/42) of pooled circulating @entity2 cells, whereas only 29% (14/48) were @entity4 positive. Confocal microscopy confirmed the localization of @entity5 probe in suspicious circulating cells. Suspicious circulating elements were also observed in healthy donors and did not show any epithelial associated antigens. A significantly lower number of suspicious circulating cells in healthy donors compared to @entity2 @entity0 was found. CONCLUSIONS: Among the heterogeneous cell population isolated by depletion procedure, the coexistence of cells with epithelial and/or mesenchymal phenotype suggests that EMT may participate to transendothelial invasion and migration of @entity1 cells in advanced @entity2 . The finding of cells with neither @entity4 or EMT phenotype, retrieved after non- @entity4 -based systems, underlines the presence of suspicious elements in the blood of both @entity2 @entity0 and healthy donors. Further phenotyping and molecular analyses are necessary to fully characterize these circulating elements.

title: Isolation and Characterization of Circulating @entity1 Cells in Squamous Cell Carcinoma of the Lung Using a Non- XXXX -Based Capture Method.

answer: @entity4


abstract: INTRODUCTION: The exclusion of circulating @entity1 cells (CTCs) that have lost epithelial antigens during the epithelial-to-mesenchymal transition (EMT) process by using @entity4 ( @entity4 ) based capture methods is still a matter of debate. In this study, cells obtained after depletion procedure from blood samples of @entity2 ( @entity2 ) @entity0 were identified based on morphology and characterized with the combination of FISH assessment and immunophenotypic profile. MATERIALS AND METHODS: Five mL blood samples, collected from 55 advanced @entity2 @entity0 , were analyzed by a non- @entity4 -based capture method. After depletion of leukocytes and erythroid cells, the negative fraction was characterized by both FISH using a @entity5 ( @entity5 ) probe and by immunocytochemistry. Thirty healthy donors were also tested. RESULTS: Based on morphology (nuclear dimension >= 10  m, shape and hypercromatic aspect) suspicious circulating cells clearly distinguishable from contaminant leukocytes were observed in 49/55 (89%) @entity2 @entity0 . Thirty-four of the 44 (77%) samples evaluable for @entity5 FISH showed >=  6 @entity5 gene copy number on average per cell. @entity3 expression involved 43% (18/42) of pooled circulating @entity2 cells, whereas only 29% (14/48) were @entity4 positive. Confocal microscopy confirmed the localization of @entity5 probe in suspicious circulating cells. Suspicious circulating elements were also observed in healthy donors and did not show any epithelial associated antigens. A significantly lower number of suspicious circulating cells in healthy donors compared to @entity2 @entity0 was found. CONCLUSIONS: Among the heterogeneous cell population isolated by depletion procedure, the coexistence of cells with epithelial and/or mesenchymal phenotype suggests that EMT may participate to transendothelial invasion and migration of @entity1 cells in advanced @entity2 . The finding of cells with neither @entity4 or EMT phenotype, retrieved after non- @entity4 -based systems, underlines the presence of suspicious elements in the blood of both @entity2 @entity0 and healthy donors. Further phenotyping and molecular analyses are necessary to fully characterize these circulating elements.

title: Isolation and Characterization of Circulating XXXX Cells in Squamous Cell Carcinoma of the Lung Using a Non- @entity4 -Based Capture Method.

answer: @entity1


abstract: RATIONALE: Rhinoviruses (RVs) are a major cause of symptomatic @entity3 in all age groups. However, RVs can frequently be detected in asymptomatic individuals. OBJECTIVES: To evaluate the ability of host transcriptional profiling to differentiate between symptomatic RV @entity1 and incidental detection in @entity0 . METHODS: Previously healthy @entity0 younger than 2 years old (n   =   151) were enrolled at four study sites and classified into four clinical groups: RV- healthy control subjects (n   =   37), RV+ asymptomatic subjects (n   =   14), RV+ outpatients (n   =   30), and RV+ inpatients (n   =   70). Host responses were analyzed using whole-blood RNA transcriptional profiles. MEASUREMENTS AND MAIN RESULTS: RV @entity1 induced a robust transcriptional signature, which was validated in three independent cohorts and by quantitative real-time polymerase chain reaction with high prediction accuracy. The immune profile of symptomatic RV @entity1 was characterized by overexpression of innate immunity and underexpression of adaptive immunity genes, whereas negligible changes were observed in asymptomatic RV+ subjects. Unsupervised hierarchical clustering identified two main clusters of subjects. The first included 93% of healthy control subjects and 100% of asymptomatic RV+ subjects, and the second comprised 98% of RV+ inpatients and 88% of RV+ outpatients. Genomic scores of healthy control subjects and asymptomatic RV+ @entity0 were similar and significantly lower than those of RV+ inpatients and outpatients (P   <   0.0001). CONCLUSIONS: Symptomatic RV @entity1 induced a robust and reproducible transcriptional signature, whereas identification of RV in asymptomatic @entity0 was not associated with significant systemic transcriptional immune responses. Transcriptional profiling represents a useful tool to discriminate between active @entity1 and incidental @entity2 detection.

title: Rhinovirus Detection in Symptomatic and Asymptomatic XXXX : Value of Host Transcriptome Analysis.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVE: Parents' attitudes toward MMR vaccine and measles, mumps and @entity1 relate to their @entity0 's MMR status, therefore improving these attitudes is central to improving current suboptimal MMR uptake. However, no study has yet combined evidence-based, comprehensive and psychometrically validated assessment of these attitudes with reliable objective MMR status data, in order to identify through multivariate analyses the strongest attitudinal predictors of MMR uptake for interventions to target. The present study fills this lacuna by developing and testing a robust evidence-based MMR attitudes measurement instrument. DESIGN: Cross-sectional self-administered postal/telephone questionnaire with objective behavioural outcome. SETTING AND @entity0 : 535 parents of @entity0 aged 5-18 in London and north-west England, UK (response rate 18.1%). Recruitment via Primary Care Trust records, age-stratified purposive sample with suboptimally immunised cases oversampled. MAIN OUTCOME MEASURES: Parents' responses to evidence-based measurement instrument comprising 20 attitude/previous behaviour items (collapsing to 5 scales) and 7 demographic items, and their @entity0 's PCT-recorded 5th birthday status for MMR dose 1 (on-time, late or none) and MMR dose 2 (on-time or none). RESULTS: The attitudes measurement instrument was psychometrically robust: content valid, and demonstrating good or acceptable internal consistency (Cronbach's alpha=0.55-0.75 for all scales), test-retest reliability (Pearson's correlation >0.60-0.80, p<0.01 to <0.001 for all scales and 11 individual items), concurrent/construct validity (t-tests for difference between MMR status groups p<0.05 for four scales and thirteen individual items), and predictive/criterion validity (OR=0.66, 95% confidence interval=0.48-0.92 to OR=1.97, 95% CI=1.18-3.31 for three scales and five individual items). Black and minority ethnicity (OR=1.94, 95% CI=1.15-3.30 to OR=4.15, 95% CI=2.40-7.19), positive MMR attitudes (OR=1.63, 95% CI=1.00-2.66 to OR=1.97, 95% CI=1.18-1.31), and positive social attitudes (OR=1.64, 95% CI=1.23-2.40 to OR=1.72, 95% CI=1.13-2.38) independently predicted uptake for both MMR doses. MMR status groups differed most strongly on preference for single measles, mumps and @entity2 vaccines (6-9% variance in status explained), previous MMR acceptance/rejection (5-9%), and wishing to protect others through vaccinating one's own @entity0 (6-8%). CONCLUSIONS: The measurement instrument is robust on multiple validity and reliability dimensions, and is appropriate for use in research and practice as a tool for designing and evaluating interventions. Parents appear to act in line with their attitudes toward MMR vaccine, though attitudes toward @entity1 bore little relation to MMR uptake. This study indicates populations and attitudes to be prioritized in MMR uptake improvement interventions.

title: Attitudinal and demographic predictors of measles, mumps and XXXX (MMR) vaccine acceptance: development and validation of an evidence-based measurement instrument.

answer: @entity2


abstract: OBJECTIVE: To monitor @entity1 after radiofrequency ablation for @entity2 . DESIGN: Measurement of PR interval from 12 lead surface electrocardiograms before; at 0, 24, 48, 72, and 96 hours; and at 1 and 6 months after radiofrequency ablation. @entity0 : 40 consecutive @entity0 with @entity2 . The anterior approach was used in 23 @entity0 , the posterior approach in 17. RESULTS: With the anterior approach the PR interval increased significantly and progressively until 48 hours after ablation (maximum 282 ( @entity3 .2) ms, before ablation 142 (29.5) ms; P < 0.0001). Up to 96 hours no further change was observed, but one month after ablation the PR interval had decreased to a value not significantly different from that 24 hours after the procedure (231 (51.2) ms). In one @entity0 total @entity1 developed 24 hours after an uncomplicated procedure and a permanent pacemaker was implanted. With the posterior approach the PR interval increased slightly in the first 24 hours (156 (22.7) ms, before ablation 144 (21.2) ms P = 0.004), but it had returned to preablation values at 1 month. One @entity0 developed second degree @entity1 during the first 24 hours after ablation, despite delivery of all radiofrequency pulses posterior to Koch's triangle at sites without His bundle deflection. PR intervals at 6 months did not differ significantly from the values at 1 month. CONCLUSION: After the anterior approach the progressive delay in @entity1 up to 48 hours after radiofrequency ablation for @entity2 warrants continuous in hospital monitoring of @entity0 for at least two days after the procedure.

title: Change in delay of @entity1 after radiofrequency catheter ablation for XXXX .

answer: @entity2


abstract: OBJECTIVE: To monitor @entity1 after radiofrequency ablation for @entity2 . DESIGN: Measurement of PR interval from 12 lead surface electrocardiograms before; at 0, 24, 48, 72, and 96 hours; and at 1 and 6 months after radiofrequency ablation. @entity0 : 40 consecutive @entity0 with @entity2 . The anterior approach was used in 23 @entity0 , the posterior approach in 17. RESULTS: With the anterior approach the PR interval increased significantly and progressively until 48 hours after ablation (maximum 282 ( @entity3 .2) ms, before ablation 142 (29.5) ms; P < 0.0001). Up to 96 hours no further change was observed, but one month after ablation the PR interval had decreased to a value not significantly different from that 24 hours after the procedure (231 (51.2) ms). In one @entity0 total @entity1 developed 24 hours after an uncomplicated procedure and a permanent pacemaker was implanted. With the posterior approach the PR interval increased slightly in the first 24 hours (156 (22.7) ms, before ablation 144 (21.2) ms P = 0.004), but it had returned to preablation values at 1 month. One @entity0 developed second degree @entity1 during the first 24 hours after ablation, despite delivery of all radiofrequency pulses posterior to Koch's triangle at sites without His bundle deflection. PR intervals at 6 months did not differ significantly from the values at 1 month. CONCLUSION: After the anterior approach the progressive delay in @entity1 up to 48 hours after radiofrequency ablation for @entity2 warrants continuous in hospital monitoring of @entity0 for at least two days after the procedure.

title: Change in delay of XXXX after radiofrequency catheter ablation for @entity2 .

answer: @entity1


abstract: OBJECTIVES: A combined atrial and arterial switch procedure was performed in selected @entity0 with congenitally corrected transposition to establish the morphological left ventricle as the systemic ventricle. Immediate and early follow up results are presented. BACKGROUND: Progressive @entity1 and @entity3 are common in @entity0 with congenitally corrected transposition who undergo repair of associated lesions. A surgical procedure which re-establishes the left ventricle as the systemic ventricle should improve functional results. METHODS: Four symptomatic @entity0 aged from 9 months to 3 years 1 month (mean 2 years 3 months) with congenitally corrected transposition and @entity4 underwent both an atrial and arterial switch procedure and were followed up for a mean of 12 months (range 6-21 months). RESULTS: There were no early or late deaths. @entity2 worsened in two @entity0 . Hospital stay ranged from 8 to 17 days (mean 13 days). The cardiothoracic ratio decreased from a mean (range) of 0.65 (0.6 to 0.71) to 0.58 (0.52 to 0.6). Currently, three @entity0 are in functional class I and one @entity0 is in functional class II. CONCLUSIONS: The combination of an atrial and an arterial switch procedure in symptomatic @entity0 with congenitally corrected transposition establishes the left ventricle as the systemic ventricle. The initial experience is encouraging with excellent immediate and early follow up results.

title: Combined atrial and arterial switch procedure for congenital corrected transposition with XXXX .

answer: @entity4


abstract: BACKGROUND: From 1984 to 1989, the Swiss Group for Clinical @entity1 Research (SAKK) performed a randomized phase III trial comparing early versus late alternating chemotherapy in @entity0 with @entity4 . @entity0 AND METHODS: 406 eligible @entity0 were entered into the trial. Regimen A consisted of PAV ( @entity7 , @entity5 , @entity10 , and Regimen B of CyMOC ( @entity6 , @entity8 , @entity9 , CCNU). Cycles were repeated as rapidly as possible. @entity0 were randomized to receive either ABABAB (early alternating chemotherapy) or AAABBB (late alternating chemotherapy). After six cycles @entity0 with limited disease in complete or partial remission and those with @entity2 in complete remission received irradiation to the primary (45 Gy) and the CNS (36 Gy). RESULTS: The overall remission rate was 87% with 31% complete remissions. The median survival of all 406 eligible @entity0 was 346 days with 15% of the @entity0 alive at two years. The overall remission rate, the rate of complete remission, the median survival and the rate of long-term survival were not significantly different in the two treatment arms. In limited disease the estimated percentages of survival at 2 years were 33% in the early and 24% in the late alternating chemotherapy arms. @entity0 with @entity2 survived significantly longer with late alternating chemotherapy than on the early alternation regimen (median survival 336 days versus 301 days, p = 0.01). In the latter @entity0 the received dose intensities (RDI) of @entity7 , @entity5 and @entity10 were significantly higher in the late-alternation arm. @entity0 treated with early alternating chemotherapy rated their @entity1 symptoms, functional states, fatigue/malaise and restriction of social activity significantly better, reflecting an improved subjective adjustment. CONCLUSIONS: Alternating chemotherapy with PAV-CyMOC plus consolidating radiotherapy is a feasible and effective treatment for @entity4 , with acceptable @entity3 . Whereas @entity0 with early alternating chemotherapy achieve a better subjective adjustment, late alternating chemotherapy allows for a higher RDI of @entity7 , @entity5 and @entity10 , which results in a significantly longer median survival of @entity0 with @entity2 .

title: Early versus late alternating chemotherapy in XXXX . Swiss Group for Clinical @entity1 Research (SAKK).

answer: @entity4


abstract: BACKGROUND: From 1984 to 1989, the Swiss Group for Clinical @entity1 Research (SAKK) performed a randomized phase III trial comparing early versus late alternating chemotherapy in @entity0 with @entity4 . @entity0 AND METHODS: 406 eligible @entity0 were entered into the trial. Regimen A consisted of PAV ( @entity7 , @entity5 , @entity10 , and Regimen B of CyMOC ( @entity6 , @entity8 , @entity9 , CCNU). Cycles were repeated as rapidly as possible. @entity0 were randomized to receive either ABABAB (early alternating chemotherapy) or AAABBB (late alternating chemotherapy). After six cycles @entity0 with limited disease in complete or partial remission and those with @entity2 in complete remission received irradiation to the primary (45 Gy) and the CNS (36 Gy). RESULTS: The overall remission rate was 87% with 31% complete remissions. The median survival of all 406 eligible @entity0 was 346 days with 15% of the @entity0 alive at two years. The overall remission rate, the rate of complete remission, the median survival and the rate of long-term survival were not significantly different in the two treatment arms. In limited disease the estimated percentages of survival at 2 years were 33% in the early and 24% in the late alternating chemotherapy arms. @entity0 with @entity2 survived significantly longer with late alternating chemotherapy than on the early alternation regimen (median survival 336 days versus 301 days, p = 0.01). In the latter @entity0 the received dose intensities (RDI) of @entity7 , @entity5 and @entity10 were significantly higher in the late-alternation arm. @entity0 treated with early alternating chemotherapy rated their @entity1 symptoms, functional states, fatigue/malaise and restriction of social activity significantly better, reflecting an improved subjective adjustment. CONCLUSIONS: Alternating chemotherapy with PAV-CyMOC plus consolidating radiotherapy is a feasible and effective treatment for @entity4 , with acceptable @entity3 . Whereas @entity0 with early alternating chemotherapy achieve a better subjective adjustment, late alternating chemotherapy allows for a higher RDI of @entity7 , @entity5 and @entity10 , which results in a significantly longer median survival of @entity0 with @entity2 .

title: Early versus late alternating chemotherapy in @entity4 . Swiss Group for Clinical XXXX Research (SAKK).

answer: @entity1


abstract: Eye-head coordination was measured in @entity0 with @entity1 as they made horizontal gaze shifts in response to predictable and unpredictable target steps and to targets moving smoothly with either constant or sinusoidally varying velocity. @entity0 preferred not to move their heads for both large and small amplitude gaze shifts. Both eye and head movement reaction times were prolonged. Saccades were hypometric and, frequently, slow. @entity3 were also slow, hypometric, and varied in amplitude for target shifts of a given amplitude. @entity4 ( @entity4 ) that normally stabilize gaze direction during head movement varied in gain from zero to greater than unity, and often drove the eyes off target. @entity2 occurred most commonly in @entity0 with abnormal vestibulo-ocular reflex (VOR) gain in darkness. We attribute these abnormalities of programming combined eye-head saccades to dysfunction of striatonigralcollicular circuits. Smooth gaze pursuit gain, the ratio of gaze velocity to target velocity, was lowered in @entity0 while tracking sinusoidal targets at 0.3, 0.5 and 1.0 Hz. Some @entity0 could track these targets with the head fixed but not with the head free. We attribute this to abnormal suppression of the vestibuloocular reflex. The results indicate that @entity1 impairs motor programming of coordinated eye-head gaze saccades and disrupts normal interaction between head movement and the VOR.

title: Ocular motor deficits in @entity1 . III. Coordination of eye and XXXX .

answer: @entity3


abstract: Eye-head coordination was measured in @entity0 with @entity1 as they made horizontal gaze shifts in response to predictable and unpredictable target steps and to targets moving smoothly with either constant or sinusoidally varying velocity. @entity0 preferred not to move their heads for both large and small amplitude gaze shifts. Both eye and head movement reaction times were prolonged. Saccades were hypometric and, frequently, slow. @entity3 were also slow, hypometric, and varied in amplitude for target shifts of a given amplitude. @entity4 ( @entity4 ) that normally stabilize gaze direction during head movement varied in gain from zero to greater than unity, and often drove the eyes off target. @entity2 occurred most commonly in @entity0 with abnormal vestibulo-ocular reflex (VOR) gain in darkness. We attribute these abnormalities of programming combined eye-head saccades to dysfunction of striatonigralcollicular circuits. Smooth gaze pursuit gain, the ratio of gaze velocity to target velocity, was lowered in @entity0 while tracking sinusoidal targets at 0.3, 0.5 and 1.0 Hz. Some @entity0 could track these targets with the head fixed but not with the head free. We attribute this to abnormal suppression of the vestibuloocular reflex. The results indicate that @entity1 impairs motor programming of coordinated eye-head gaze saccades and disrupts normal interaction between head movement and the VOR.

title: Ocular motor deficits in XXXX . III. Coordination of eye and @entity3 .

answer: @entity1


abstract: BACKGROUND: Nephron-sparing surgery (NSS) can safely be performed with slightly higher complication rates than radical nephrectomy (RN), but proof of oncologic effectiveness is lacking. OBJECTIVE: To compare @entity3 ( @entity3 ) and time to progression. DESIGN, SETTING, AND @entity0 : From March 1992 to January 2003, when the study was prematurely closed because of poor accrual, 541 @entity0 with small ( <=5 cm), solitary, T1-T2 N0 M0 (Union Internationale Contre le Cancer [UICC] 1978) @entity1 suspicious for @entity4 ( @entity4 ) and a normal contralateral kidney were randomised to NSS or RN in European Organisation for Research and Treatment of Cancer Genito-Urinary Group (EORTC-GU) noninferiority phase 3 trial 30904. INTERVENTION: @entity0 were randomised to NSS (n=268) or RN (n=273) together with limited lymph node dissection (LND). MEASUREMENTS: Time to event end points was compared with log-rank test results. RESULTS AND LIMITATIONS: Median follow-up was 9.3 yr. The intention-to-treat (ITT) analysis showed 10-yr @entity3 rates of 81.1% for RN and 75.7% for NSS. With a hazard ratio (HR) of 1.50 (95% confidence interval [CI], 1.03-2.16), the test for noninferiority is not significant (p=0.77), and test for superiority is significant (p=0.03). In @entity4 @entity0 and clinically and pathologically eligible @entity0 , the difference is less pronounced (HR=1.43 and HR=1.34, respectively), and the superiority test is no longer significant (p=0.07 and p=0.17, respectively). Only 12 of 117 deaths were the result of @entity2 (four RN and eight NSS). Twenty-one @entity0 progressed (9 after RN and 12 after NSS). Quality of life and renal function outcomes have not been addressed. CONCLUSIONS: Both methods provide excellent oncologic results. In the ITT population, NSS seems to be significantly less effective than RN in terms of @entity3 . However, in the targeted population of @entity4 @entity0 , the trend in favour of RN is no longer significant. The small number of progressions and deaths from @entity2 cannot explain any possible @entity3 differences between treatment types.

title: A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for XXXX .

answer: @entity4


abstract: AIMS: The purpose of this study was to determine the effect of exercise on dyssynchrony in @entity0 with @entity1 . METHODS AND RESULTS: Sixty @entity0 with a left ventricular ejection fraction (LVEF)  <= 35% were studied. @entity3 ( @entity3 ), intraventricular mechanical delay [Ts-(lateral-septal)], and left ventricular filling ratio were measured at rest and during exercise. Significant @entity3 was defined as a difference between aortic and pulmonary pre-ejection times of >40 ms. @entity2 was defined as a Ts-(lateral-septal) >65 ms. Forty-five @entity0 with no dyssynchrony at rest were analysed (age 62    14; LVEF 28    6%) and compared with a control group of 15 @entity0 with known dyssynchrony at rest. None of the 45 @entity0 without dyssynchrony at rest developed dyssynchrony during exercise based on @entity3 and Ts-(lateral-septal). In the control group, @entity3 decreased from 65    19 to 33    11 ms (P< 0.001) during exercise, whereas Ts-(lateral-septal) did not change. Persistence of dyssynchrony during exercise (decrease of @entity3 <60%) was significantly associated with response to cardiac resynchronization therapy (CRT). Whereas all 10 responders had persistent dyssynchrony during exercise, 4 of the 5 non-responders (80%) had an exercise-induced decrease of @entity3 >60% (P< 0.004). CONCLUSION: Exercise does not elicit mechanical dyssynchrony in @entity0 without dyssynchrony at rest. In @entity0 with significant dyssynchrony at rest, exercise-induced decrease of @entity3 is common. Persistence of dyssynchrony during exercise might be a novel predictor of response to CRT.

title: Effects of physical exercise on cardiac dyssynchrony in @entity0 with XXXX .

answer: @entity1


abstract: AIMS: The purpose of this study was to determine the effect of exercise on dyssynchrony in @entity0 with @entity1 . METHODS AND RESULTS: Sixty @entity0 with a left ventricular ejection fraction (LVEF)  <= 35% were studied. @entity3 ( @entity3 ), intraventricular mechanical delay [Ts-(lateral-septal)], and left ventricular filling ratio were measured at rest and during exercise. Significant @entity3 was defined as a difference between aortic and pulmonary pre-ejection times of >40 ms. @entity2 was defined as a Ts-(lateral-septal) >65 ms. Forty-five @entity0 with no dyssynchrony at rest were analysed (age 62    14; LVEF 28    6%) and compared with a control group of 15 @entity0 with known dyssynchrony at rest. None of the 45 @entity0 without dyssynchrony at rest developed dyssynchrony during exercise based on @entity3 and Ts-(lateral-septal). In the control group, @entity3 decreased from 65    19 to 33    11 ms (P< 0.001) during exercise, whereas Ts-(lateral-septal) did not change. Persistence of dyssynchrony during exercise (decrease of @entity3 <60%) was significantly associated with response to cardiac resynchronization therapy (CRT). Whereas all 10 responders had persistent dyssynchrony during exercise, 4 of the 5 non-responders (80%) had an exercise-induced decrease of @entity3 >60% (P< 0.004). CONCLUSION: Exercise does not elicit mechanical dyssynchrony in @entity0 without dyssynchrony at rest. In @entity0 with significant dyssynchrony at rest, exercise-induced decrease of @entity3 is common. Persistence of dyssynchrony during exercise might be a novel predictor of response to CRT.

title: Effects of physical exercise on cardiac dyssynchrony in XXXX with @entity1 .

answer: @entity0


abstract: OBJECTIVE: Many @entity0 with @entity3 desire uterine conservation. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a new non-invasive therapy. We describe our early results regarding efficacy and safety of MRgFUS for the treatment of uterine @entity4 . @entity0 AND METHODS: Fifty-two French @entity0 , over 18 years of age, who were candidates for surgical myomectomy, @entity2 due to symptomatic @entity3 were treated by MRgFUS (ExAblate 2000(  ), InSightec) and followed up for at least 6 months. Intramural or @entity3 with a size between 4-12 cm and a T2 low intensity MRI image were selected in @entity0 with no abdominal scar and no bowel interposition. The modified symptom severity score (SSS) was examined before and after the treatment at 6 months. Second treatment rate during the first follow-up year was reported. RESULTS: No serious complications were recorded during the treatments or follow-up period. Seven @entity0 had @entity1 mostly because of bowel interposition, six of them had uterine artery embolisation. The mean modified SSS value for @entity0 before MRgFUS was 41/100 and the values diminished significantly to a mean value of 22/100. A total of 65% of @entity0 had a reduction of at least 10 points (n=22) (initial score of 41 [29; 62] and 22 [16; 46] at 6 month follow-up). Good correlation was observed between @entity3 destruction and the symptoms score. During the follow-up period, ten @entity0 (19%) required invasive interventions (six hysterectomies, two embolisations and two myomectomies). The average reduction in @entity3 volume determined by MR imaging at 6 months after treatment was 14%. This volume reduction is poorly correlated with the @entity3 's treated volume of 36.4% (6-74%). CONCLUSION: MRgFUS can safely be used for symptomatic treatment and avoid the need for surgical intervention in most @entity0 . Additional follow-up is needed to determine the long-term durability of this promising non-invasive approach and to obtain reimbursement.

title: [French first results using magnetic resonance-guided focused ultrasound for XXXX treatment].

answer: @entity3


abstract: OBJECTIVE:    To describe the possible association (pathophysiologic and clinical features) between exertional @entity1 (EHS) and @entity3 ( @entity3 ). BACKGROUND:    Both EHS and @entity3 are acute and life-threatening disorders. It has repeatedly been shown that EHS can occur in well-trained @entity0 with known @entity3 -associated mutation in the @entity7 gene in the absence of any extreme environmental conditions or extreme physical activity, thereby supporting a possible link between EHS and @entity3 . In this case, a highly trained 30-year-old male athlete suddenly collapsed while running. He had initial @entity2 (40.2  C) and progressive @entity4 requiring medical management in an intensive care unit. After he recovered completely, a maximal exercise test was performed and showed an obvious abnormality of oxidative metabolism in muscle; genetic analysis of the @entity7 gene identified a heterozygous missense variation @entity8 . Consequently, the athlete was given appropriate information and allowed to progressively return to sport competition. DIFFERENTIAL DIAGNOSIS:    Doping, use of drugs and toxic agents, exercise-associated @entity5 , exertional @entity2 . TREATMENT:    Initial management started with the basic resuscitative guidelines of airway, breathing, and circulation (intubation). Cooling, administration of fresh frozen plasma, and intensive rehydration resulted in improvement. UNIQUENESS:    To our knowledge, ours is the first description of this @entity3 mutation ( @entity8 ) in the @entity7 gene that was associated with exertional @entity6 involving a dramatic impairment of oxidative metabolism in muscle. CONCLUSIONS:    Common features are shared by EHS and @entity3 . Careful attention must therefore be paid to athletes who experience EHS, especially in temperate climates or when there are no other predisposing factors.

title: Exertional Heat XXXX and Susceptibility to Malignant @entity2 in an Athlete: Evidence for a Link?

answer: @entity1


abstract: OBJECTIVE:    To describe the possible association (pathophysiologic and clinical features) between exertional @entity1 (EHS) and @entity3 ( @entity3 ). BACKGROUND:    Both EHS and @entity3 are acute and life-threatening disorders. It has repeatedly been shown that EHS can occur in well-trained @entity0 with known @entity3 -associated mutation in the @entity7 gene in the absence of any extreme environmental conditions or extreme physical activity, thereby supporting a possible link between EHS and @entity3 . In this case, a highly trained 30-year-old male athlete suddenly collapsed while running. He had initial @entity2 (40.2  C) and progressive @entity4 requiring medical management in an intensive care unit. After he recovered completely, a maximal exercise test was performed and showed an obvious abnormality of oxidative metabolism in muscle; genetic analysis of the @entity7 gene identified a heterozygous missense variation @entity8 . Consequently, the athlete was given appropriate information and allowed to progressively return to sport competition. DIFFERENTIAL DIAGNOSIS:    Doping, use of drugs and toxic agents, exercise-associated @entity5 , exertional @entity2 . TREATMENT:    Initial management started with the basic resuscitative guidelines of airway, breathing, and circulation (intubation). Cooling, administration of fresh frozen plasma, and intensive rehydration resulted in improvement. UNIQUENESS:    To our knowledge, ours is the first description of this @entity3 mutation ( @entity8 ) in the @entity7 gene that was associated with exertional @entity6 involving a dramatic impairment of oxidative metabolism in muscle. CONCLUSIONS:    Common features are shared by EHS and @entity3 . Careful attention must therefore be paid to athletes who experience EHS, especially in temperate climates or when there are no other predisposing factors.

title: Exertional Heat @entity1 and Susceptibility to Malignant XXXX in an Athlete: Evidence for a Link?

answer: @entity2


abstract: Of 175 @entity0 treated surgically for potentially lethal or refractory @entity3 , 53 underwent mapping and definitive operation using cryoablative techniques as the primary or adjunctive method. Included were 16 @entity0 with @entity7 caused by accessory pathways ( @entity8 ) in the right anterior or posterior paraseptal location. Cryoablation was successful in abolishing @entity4 in 93.7% (15 of 16). Six @entity0 (100%) with permanent junctional reciprocating @entity4 were cured by cryoablation. Eighteen of 19 @entity0 with @entity9 were treated by cryoablation alone or in combination with excision of the @entity5 , with success in 15 (83.3%). Five of these were left atrial foci cured by cryoablation. Fourteen right atrial foci were treated by excision of the appendage only (1 @entity0 ), excision of the appendage and local cryoablation (8 @entity0 ), and cryoablation alone (5 @entity0 ). Three of these underwent partial (2 @entity0 ) or complete (1 @entity0 ) atrial disconnection after excisional and cryoablative techniques failed to control the @entity4 . Multiple ectopic atrial foci were common (9 @entity0 ), and successful cryoablation was accomplished in 100% of the @entity0 with a single @entity9 (10 @entity0 ) but in only 66% of those with multiple foci. Thirteen of 19 @entity0 with critical @entity6 were treated by cryoablation at the site of the ectopic focus, either alone or in combination with excision of the area. Elimination of @entity4 was accomplished in 13 @entity0 (100%). @entity2 ( @entity1 ) was the histological diagnosis in 11 of the @entity0 with @entity6 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Cryoablative techniques in the treatment of XXXX .

answer: @entity3


abstract: BACKGROUND: Raising the awareness of childhood @entity1 symptoms can reduce the frequency of @entity1 ( @entity1 ) at onset of @entity2 ( @entity2 ). However, data on the effectiveness of such interventions are limited. The aim of the study was to describe trends of @entity1 at onset of childhood @entity2 during 2005-2014 and assess the impact of a @entity1 campaign launched late 2010. METHODS: Data of @entity0 <12 years presented with @entity1 at diagnosis were analyzed according to age, gender and year of diagnosis. The frequency and severity of @entity1 before and during the 4 years campaign were compared. RESULTS: During 2005-2014, 44.9% (243/541) of @entity0 diagnosed with @entity2 presented with @entity1 . Of these, 22.7% had pH <7.1. In both genders @entity1 was higher in @entity0 <6 years (47.8% vs. 40%; p<0.01) and more severe in <3 years old compared to older @entity0 (30% vs. 20%; p<0.01). Following the awareness campaign @entity1 rate dropped from 48% in 2010 to 39% in 2014 and 15.8% had severe @entity1 compared to 26.1% in 2005-2010 (p<0.01). This trend was observed in both genders and across age groups. In @entity0 <3 years the reduction in @entity1 frequency and severity was not statistically significant (p=0.15 and p=0.42, respectively). CONCLUSIONS: In NWSA, the frequency and severity of @entity1 at onset of childhood @entity2 were reduced following 4 years awareness campaign; but the rate is still high. Maintaining the campaign may result in further improvement following a longer period of observation.

title: Reduced frequency and severity of ketoacidosis at diagnosis of childhood XXXX in Northwest Saudi Arabia.

answer: @entity2


abstract: @entity5 remains a serious illness with a high mortality. In more than 75% of 417 @entity0 , the @entity2 was due to gram-positive microorganisms. The non- @entity3 @entity0 (33%) were elderly and debilitated with advanced illness that preceded the @entity5 . The @entity3 @entity0 (67%) were young and were infected with multiple kinds of microorganisms. The blood cultures grew strains of @entity4 resistant to @entity6 and @entity7 in a majority of @entity0 . Gram-negative microorganisms and fungi were cultured almost exclusively from samples from the @entity3 @entity0 . The high mortality among the non- @entity3 @entity0 (28%) was related to their advanced age and debilitating illness. The high mortality among the @entity3 @entity0 (21%) was related to the complex bacteriology of their infections and the severe anatomical disruption of the valvular complexes of the heart. When cured of their disease after treatment with intravenously administered antibiotics or a valve procedure or both, their long-term survival was related to whether or not they abstained from their habit. If the @entity0 abstained from the use of drugs, the chances of survival were good; if not, @entity1 invariably ensued. This experience strongly supports our contention that if a @entity0 returns to the use of drugs and reinfects the valve after initial cure, a second valve operation is contraindicated.

title: Management of XXXX : seventeen years' experience.

answer: @entity5


abstract: Fifty-one successive @entity0 treated with intravenous streptokinase 1.7 +/- 0.8 (mean +/- SD) hours after onset of symptoms of @entity2 were evaluated during a three-month posthospital follow-up period. Coronary angiography was performed four to nine days after the initial hospital admission. Twenty-eight @entity0 had a second late angiogram. Forty-one @entity0 had successful reperfusion but only 25% of all @entity0 were without significant clinical cardiovascular manifestations during this period. @entity5 @entity4 occurred in 21 @entity0 , an abnormal stress test result was present in 28 @entity0 , eight @entity0 developed @entity3 , and five @entity0 had reinfarction. An intervention with percutaneous transluminal coronary angioplasty or coronary artery bypass graft was performed in 15 (37%) of 41 reperfused @entity0 . A significantly higher intervention rate was present in @entity0 treated with streptokinase within one hour following the onset of symptoms. Early reocclusion (within three months of the @entity5 ) was noted in @entity0 with 60% or more residual stenosis in their @entity5 -related coronary artery. These @entity0 also had a significantly greater incidence of @entity4 . Our findings indicate that early thrombolytic therapy of @entity2 preserves myocardium, and since the @entity5 is patent, but narrowed, the jeopardized area is responsible for a high-risk syndrome with an increased likelihood of @entity1 symptoms. An early aggressive approach may be indicated, especially for @entity0 with greater than 60% residual stenosis in their @entity5 -related coronary artery.

title: Early treatment of XXXX with intravenous streptokinase. A high-risk syndrome.

answer: @entity2


abstract: BACKGROUND: @entity1 with @entity4 ( @entity3 ) on a benign breast biopsy specimen are at increased risk for the development of @entity0 . However, the relation between the type and extent of @entity3 ( @entity4 [ @entity4 ] vs @entity3 [ @entity3 ]) and the magnitude of the @entity0 risk is not well defined. METHODS: A nested case-control study of @entity5 and @entity0 risk was conducted. @entity1 with @entity0 and prior benign breast biopsy findings (488 cases) were matched to @entity1 with prior benign breast biopsy findings who were free from @entity0 (1907 controls). Benign breast biopsy slides were reviewed and categorized as nonproliferative, proliferative without atypia, or @entity3 ( @entity4 or @entity3 ). The number of foci of @entity3 was also recorded. RESULTS: Among @entity1 with @entity4 , the interrelation between the extent of atypia and @entity0 risk was not significant (odds ratio [OR] for 1 or 2 foci, 3.5; 95% confidence interval [CI], 2.2-5.6; OR for >= 3 foci, 2.7; 95% CI, 1.4-5.1; P   =   .41). Similarly, although the risk with @entity3 was higher for those with >= 3 foci than for those with <3 foci, the difference was not statistically significant (OR for 1 or 2 foci, 5.2; 95% CI, 2.7-10.0; OR for >= 3 foci, 8.0; 95% CI, 4.5-14.2; P   =   .19). CONCLUSIONS: This analysis demonstrates that the extent of @entity4 or @entity3 does not significantly contribute to @entity0 risk. The lack of a significant dose-response relation between the extent and type of atypia and @entity0 risk suggests that it would be premature to use the extent of atypia to influence management decisions for @entity1 with @entity4 or @entity3 . @entity2 2016;122:515-520.    2015 American @entity2 Society.

title: @entity0 risk by extent and type of XXXX : An update from the Nurses' Health Studies.

answer: @entity4


abstract: BACKGROUND: @entity1 with @entity4 ( @entity3 ) on a benign breast biopsy specimen are at increased risk for the development of @entity0 . However, the relation between the type and extent of @entity3 ( @entity4 [ @entity4 ] vs @entity3 [ @entity3 ]) and the magnitude of the @entity0 risk is not well defined. METHODS: A nested case-control study of @entity5 and @entity0 risk was conducted. @entity1 with @entity0 and prior benign breast biopsy findings (488 cases) were matched to @entity1 with prior benign breast biopsy findings who were free from @entity0 (1907 controls). Benign breast biopsy slides were reviewed and categorized as nonproliferative, proliferative without atypia, or @entity3 ( @entity4 or @entity3 ). The number of foci of @entity3 was also recorded. RESULTS: Among @entity1 with @entity4 , the interrelation between the extent of atypia and @entity0 risk was not significant (odds ratio [OR] for 1 or 2 foci, 3.5; 95% confidence interval [CI], 2.2-5.6; OR for >= 3 foci, 2.7; 95% CI, 1.4-5.1; P   =   .41). Similarly, although the risk with @entity3 was higher for those with >= 3 foci than for those with <3 foci, the difference was not statistically significant (OR for 1 or 2 foci, 5.2; 95% CI, 2.7-10.0; OR for >= 3 foci, 8.0; 95% CI, 4.5-14.2; P   =   .19). CONCLUSIONS: This analysis demonstrates that the extent of @entity4 or @entity3 does not significantly contribute to @entity0 risk. The lack of a significant dose-response relation between the extent and type of atypia and @entity0 risk suggests that it would be premature to use the extent of atypia to influence management decisions for @entity1 with @entity4 or @entity3 . @entity2 2016;122:515-520.    2015 American @entity2 Society.

title: XXXX risk by extent and type of @entity4 : An update from the Nurses' Health Studies.

answer: @entity0


abstract: BACKGROUND-- @entity0 with @entity2 may have abnormal brain imaging. Lesions demonstrated on computerized tomography or magnetic resonance imaging often suggest the underlying cause of the @entity2 , and may prompt an invasive investigation for diagnosis and treatment. In an increasingly recognized subset of @entity0 however, the imaged lesions spontaneously resolve. While poorly understood, these 'disappearing' lesions may in fact be the consequence of @entity2 , rather than the cause. Two @entity0 with 'disappearing' lesions are presented: the first @entity0 had a proven cause, the second a probable one. Case 1. A @entity0 with new onset @entity2 had an abnormal MRI. An angiogram confirmed @entity3 of the straight sinus. On follow-up, she was doing well; repeat imaging was normal with resolution of the lesion. Case 2. A @entity0 with a long @entity2 history had been well controlled on medications, and had no change in frequency of her @entity2 . She was found to have a @entity4 . MRI revealed a right parieto-occipital lesion. The @entity0 refused further work-up and was lost to follow-up. She returned almost a year later; repeat imaging was normal. CONCLUSION-- @entity0 with @entity2 and abnormal imaging suggestive of structural lesions may occasionally have lesions that resolve spontaneously. While some diagnoses remain elusive, an important consideration to exclude in these @entity0 is @entity1 .

title: XXXX and 'disappearing' brain lesions.

answer: @entity2


abstract: UNASSIGNED: The vomeronasal organ (VNO) of five-month-old fetuses was examined immunohistochemically by the use of an antiserum to @entity1 ( @entity1 ). Our purpose was to identify if the @entity0 fetal VNO is lined by neuroepithelium. The @entity1 antiserum labeled abundant cells within the vomeronasal epithelium (VE), nerve fiber bundles in its lamina propria, and cells associated with these bundles. @entity1 -immunoreactive (ir) vomeronasal epithelial cells were classified into three subtypes. Type I cells, about 40% of the total cells observed, did not have any processes and tended to be located in the basal layer of the VE. Type II cells had a single apical process that projected toward the lumen, ending at the epithelial surface. Type III cells sent a prominent process mainly toward the basement membrane, and occupied about 20% of the total cells observed. In the lamina propria, a considerable number of @entity1 -ir cells were observed. Some of them were present in nerve fiber bundles and contained processes parallel to the bundles. In addition, @entity1 -ir nerve fiber bundles and cells associated with them were even present in the portion of the nasal septal mucosa that was very close to the brain. The present results strongly suggest that the VE in @entity0 fetuses at mid-gestation is a neuroepithelium and that the VE may produce migrating cells toward the brain. This article is protected by copyright. All rights reserved.

title: Morphological Analysis for Neuron-like Cells in the Vomeronasal Organ of XXXX Fetuses at the middle of gestation.

answer: @entity0


abstract: The efficacy of oral @entity1 as bridge therapy in @entity2 ( @entity2 ) was studied. Forty @entity0 starting @entity3 were randomized to receive either @entity1 or placebo for 18 weeks. The dose was 10 mg/day in the first 12 weeks, 7.5 mg/day in weeks 13 and 14, 5 mg/day in weeks 15 and 16, and 2.5 mg/day in weeks 17 and 18. @entity0 were followed for 44 weeks. We found that disease activity was significantly lower in the @entity1 group as early as week 1 and continued up to week 12. Response to @entity1 was noticed in 60% of the @entity0 . After tapering @entity1 , a rebound deterioration was noticed at weeks 20 and 24 in 58% of the responders. No significant differences in X-ray progression were found between the two groups. We concluded that oral @entity1 (10 mg/day) significantly reduces short-term disease activity in 60% of @entity0 with active @entity2 . The rebound deterioration after tapering the dose means that bridge therapy with @entity1 using this dose-reduction scheme is not recommended.

title: Oral steroids as bridge therapy in XXXX @entity0 starting with parenteral gold. A randomized double-blind placebo-controlled trial.

answer: @entity2


abstract: The efficacy of oral @entity1 as bridge therapy in @entity2 ( @entity2 ) was studied. Forty @entity0 starting @entity3 were randomized to receive either @entity1 or placebo for 18 weeks. The dose was 10 mg/day in the first 12 weeks, 7.5 mg/day in weeks 13 and 14, 5 mg/day in weeks 15 and 16, and 2.5 mg/day in weeks 17 and 18. @entity0 were followed for 44 weeks. We found that disease activity was significantly lower in the @entity1 group as early as week 1 and continued up to week 12. Response to @entity1 was noticed in 60% of the @entity0 . After tapering @entity1 , a rebound deterioration was noticed at weeks 20 and 24 in 58% of the responders. No significant differences in X-ray progression were found between the two groups. We concluded that oral @entity1 (10 mg/day) significantly reduces short-term disease activity in 60% of @entity0 with active @entity2 . The rebound deterioration after tapering the dose means that bridge therapy with @entity1 using this dose-reduction scheme is not recommended.

title: Oral steroids as bridge therapy in @entity2 XXXX starting with parenteral gold. A randomized double-blind placebo-controlled trial.

answer: @entity0


abstract: The role of @entity1 receptors in regulating the formation of recognition memory remains poorly understood. Here we show the effects of systemic administration of @entity1 receptor agonists and antagonists on the formation of memory for novel object recognition in @entity0 . In Experiment I, @entity0 received an intraperitoneal (i.p.) injection of vehicle, the selective D1 receptor agonist @entity2 (1.0 and 5.0mg/kg), or the D2 receptor agonist @entity5 (1.0 and 5.0mg/kg) immediately after training. In Experiment II, @entity0 received an injection of vehicle, the @entity1 receptor antagonist @entity4 (0.1 and 0.05 mg/kg), or the D2 receptor antagonist @entity6 (0.5 and 0.1mg/kg) before training, followed by an injection of vehicle or the nonselective @entity1 receptor agonist @entity3 (0.05 mg/kg) immediately after training. @entity2 at 5mg/kg produced an enhancement of novel object recognition memory measured at both 24 and 72 h after training, whereas the dose of 10mg/kg impaired 24-h retention. Posttraining administration of @entity5 did not affect 24-h retention. @entity3 enhanced memory in @entity0 given pretraining raclopride, suggesting that the effect was mediated by selective activation of D1 receptors. The results indicate that activation of D1 receptors can enhance recognition memory consolidation. Importantly, pharmacological activation of D1 receptors enhanced novel object recognition memory even under conditions in which control @entity0 showed significant retention.

title: Modulatory influence of XXXX receptors on consolidation of object recognition memory.

answer: @entity1


abstract: OBJECTIVE: To systematically review the research findings regarding the associations between psychosocial factors and adjustment to @entity6 in @entity0 with physical disabilities. DATA SOURCES: A key word literature search was conducted using articles listed in PubMed, PsychInfo, and CINAHL up to March 2010, and manual searches were made of all retrieved articles to identify published articles that met the review inclusion criteria. STUDY SELECTION: To be included in the review, articles needed to (1) be written in English, (2) include adults with a @entity5 who report having @entity2 , (3) include at least 1 measure of a psychosocial predictor domain, (4) include at least 1 criterion measure of @entity2 or @entity0 functioning, and (5) report the results of associations between the psychosocial factors and criterion measures used in the study. Twenty-nine studies met the inclusion criteria. DATA EXTRACTION: Three reviewers tabulated study details and findings. DATA SYNTHESIS: The disability groups studied included @entity7 ( @entity7 ), acquired amputation, @entity3 ( @entity3 ), @entity1 ( @entity1 ), and @entity8 ( @entity8 ). Psychosocial factors were shown to be significantly associated with @entity2 and @entity4 in all disability groups. The psychosocial factors most closely associated with @entity2 and @entity4 across the samples included (1) catastrophizing cognitions; (2) task persistence, guarding, and resting coping responses; and (3) perceived social support and solicitous responding social factors. @entity2 -related beliefs were more strongly associated with @entity2 and @entity4 in the @entity7 , @entity3 , @entity1 , and @entity8 groups than in the acquired amputation group. CONCLUSIONS: The findings support the importance of psychosocial factors as significant predictors of @entity2 and functioning in @entity0 with physical disabilities. Clinical trials to test the efficacy of psychosocial treatments for @entity2 and @entity4 are warranted, as are studies to determine whether psychosocial factors have a causal influence on @entity2 and adjustment in these populations.

title: Psychosocial factors and adjustment to XXXX in @entity0 with physical disabilities: a systematic review.

answer: @entity6


abstract: OBJECTIVE: To systematically review the research findings regarding the associations between psychosocial factors and adjustment to @entity6 in @entity0 with physical disabilities. DATA SOURCES: A key word literature search was conducted using articles listed in PubMed, PsychInfo, and CINAHL up to March 2010, and manual searches were made of all retrieved articles to identify published articles that met the review inclusion criteria. STUDY SELECTION: To be included in the review, articles needed to (1) be written in English, (2) include adults with a @entity5 who report having @entity2 , (3) include at least 1 measure of a psychosocial predictor domain, (4) include at least 1 criterion measure of @entity2 or @entity0 functioning, and (5) report the results of associations between the psychosocial factors and criterion measures used in the study. Twenty-nine studies met the inclusion criteria. DATA EXTRACTION: Three reviewers tabulated study details and findings. DATA SYNTHESIS: The disability groups studied included @entity7 ( @entity7 ), acquired amputation, @entity3 ( @entity3 ), @entity1 ( @entity1 ), and @entity8 ( @entity8 ). Psychosocial factors were shown to be significantly associated with @entity2 and @entity4 in all disability groups. The psychosocial factors most closely associated with @entity2 and @entity4 across the samples included (1) catastrophizing cognitions; (2) task persistence, guarding, and resting coping responses; and (3) perceived social support and solicitous responding social factors. @entity2 -related beliefs were more strongly associated with @entity2 and @entity4 in the @entity7 , @entity3 , @entity1 , and @entity8 groups than in the acquired amputation group. CONCLUSIONS: The findings support the importance of psychosocial factors as significant predictors of @entity2 and functioning in @entity0 with physical disabilities. Clinical trials to test the efficacy of psychosocial treatments for @entity2 and @entity4 are warranted, as are studies to determine whether psychosocial factors have a causal influence on @entity2 and adjustment in these populations.

title: Psychosocial factors and adjustment to @entity6 in XXXX with physical disabilities: a systematic review.

answer: @entity0


abstract: AIMS: n-3 @entity3 ( @entity6 ) are known to protect the cardiovascular system and improve blood pressure control. These important dietary constituents are converted into bioactive metabolites, but their role in regulation of the cardiovascular system is unclear. In particular, the functions of the cytochrome P450 (CYP) metabolites of n-3 @entity6 remain virtually unexplored. In this study, we examined the effects of @entity4 ( @entity5 ) on the regulation of large-conductance @entity1 -activated @entity2 (BK) channel activities in coronary arterial smooth muscle cells. METHODS AND RESULTS: Using whole-cell patch-clamp techniques, we found that @entity5 is a potent activator of BK currents in @entity0 coronary arterial smooth muscle cells with an EC(50) of 0.23    0.03   M. This effect was abolished by pre-incubation with the CYP epoxygenase inhibitor, SKF525A (10   M). The effects of @entity5 on the BK channels were reproduced by @entity8 (16,17-EpDPE) with an EC(50) of 19.7    2.8 nM. The physiological role of the CYP metabolites of @entity5 was confirmed by measuring @entity5 -mediated vasodilatation in isolated @entity0 coronary arteries. @entity5 dilated pressurized isolated coronary arteries in a dose-dependent manner, and the @entity5 effects were abolished after pre-treatment with SKF525A (10   M) or with iberiotoxin (100 nM). In addition, 16,17-EpDPE directly produced coronary vasodilatation that was @entity7 sensitive. CONCLUSION: These results suggest that @entity5 -mediated vasodilatation is mediated through CYP epoxygenase metabolites by activation of vascular BK channels.

title: Activation of vascular BK channels by XXXX is dependent on cytochrome P450 epoxygenase activity.

answer: @entity4


abstract: The aim of this research was to evaluate, within a controlled clinical study, the effects of a Delaire-type facemask or a modified Jasper Jumper (JJ) used in the treatment of @entity0 with @entity2 due to maxillary retrognathia on @entity1 ( @entity1 ). Forty-six @entity0 with @entity2 referred for orthodontic treatment were divided into two groups, a test and a control. The test group comprised 33 randomly chosen @entity0 (15 females, 18 males) aged 8-11 years. The control group included 13 @entity0 (eight females, five males) with similar features. @entity4 assessment was performed before and after treatment using a two-axis questionnaire, the Research Diagnostic Criteria for @entity1 (RDC/ @entity1 ). Qualitative data were evaluated using chi-square and McNemar tests. No statistically significant differences related to the presence of @entity4 were observed pre- or post-treatment (P > 0.05). The most commonly encountered diagnosis was @entity3 in the JJ group both before and after treatment. Evaluation of joint and muscle regions showed decreased symptoms, apart from the diagnosed discomforts, in the JJ group (P < 0.05). Reduced symptoms were observed in the Delaire group; however, this reduction was not statistically significant. An increase, not considered to be statistically significant, was observed in the control group. The Delaire-type facemask and modified JJ used in the early phase of @entity2 treatment did not result in @entity4 .

title: The effects of two methods of XXXX treatment on @entity1 .

answer: @entity2


abstract: The aim of this research was to evaluate, within a controlled clinical study, the effects of a Delaire-type facemask or a modified Jasper Jumper (JJ) used in the treatment of @entity0 with @entity2 due to maxillary retrognathia on @entity1 ( @entity1 ). Forty-six @entity0 with @entity2 referred for orthodontic treatment were divided into two groups, a test and a control. The test group comprised 33 randomly chosen @entity0 (15 females, 18 males) aged 8-11 years. The control group included 13 @entity0 (eight females, five males) with similar features. @entity4 assessment was performed before and after treatment using a two-axis questionnaire, the Research Diagnostic Criteria for @entity1 (RDC/ @entity1 ). Qualitative data were evaluated using chi-square and McNemar tests. No statistically significant differences related to the presence of @entity4 were observed pre- or post-treatment (P > 0.05). The most commonly encountered diagnosis was @entity3 in the JJ group both before and after treatment. Evaluation of joint and muscle regions showed decreased symptoms, apart from the diagnosed discomforts, in the JJ group (P < 0.05). Reduced symptoms were observed in the Delaire group; however, this reduction was not statistically significant. An increase, not considered to be statistically significant, was observed in the control group. The Delaire-type facemask and modified JJ used in the early phase of @entity2 treatment did not result in @entity4 .

title: The effects of two methods of @entity2 treatment on XXXX .

answer: @entity1


abstract: In 1961 the British Association of Urological Surgeons published its original guide to urologists and surgeons on occupational @entity1 of the urinary tract. This revised guide has been produced by the BAUS Committee on Occupational Urothelial Cancers and has broadly the same objectives as the first: 1. To give guidance on the industries and occupations (a) In which the known urothelial carcinogens have been manufactured or used and with which occupational @entity1 have been associated. (b) In which epidemiological studies have revealed an increased risk of @entity1 but the exact carcinogens have not been identified. (b) In which epidemiological studies have revealed an increased risk of @entity1 but the exact carcinogens have not been identified. (c) In which occupational @entity1 might be expected to occur but are not yet established or reported. 2. To assist the urologist in recognising cases with a possible occupational association. 3. To describe how these cases should be reported for industrial injuries benefit and @entity3 reporting (RIDDOR). 4. To outline the benefits that may be available to the @entity0 . 5. To explain the changes that were introduced on 3 October 1983 following the report by the Industrial Injuries Advisory Council on the prescription of @entity2 as a Prescribed Industrial Disease (now disease number C23) (Table 1).

title: Occupational @entity2 : a guide for clinicians. The BAUS Subcommittee on Industrial XXXX .

answer: @entity2


abstract: In 1961 the British Association of Urological Surgeons published its original guide to urologists and surgeons on occupational @entity1 of the urinary tract. This revised guide has been produced by the BAUS Committee on Occupational Urothelial Cancers and has broadly the same objectives as the first: 1. To give guidance on the industries and occupations (a) In which the known urothelial carcinogens have been manufactured or used and with which occupational @entity1 have been associated. (b) In which epidemiological studies have revealed an increased risk of @entity1 but the exact carcinogens have not been identified. (b) In which epidemiological studies have revealed an increased risk of @entity1 but the exact carcinogens have not been identified. (c) In which occupational @entity1 might be expected to occur but are not yet established or reported. 2. To assist the urologist in recognising cases with a possible occupational association. 3. To describe how these cases should be reported for industrial injuries benefit and @entity3 reporting (RIDDOR). 4. To outline the benefits that may be available to the @entity0 . 5. To explain the changes that were introduced on 3 October 1983 following the report by the Industrial Injuries Advisory Council on the prescription of @entity2 as a Prescribed Industrial Disease (now disease number C23) (Table 1).

title: Occupational XXXX : a guide for clinicians. The BAUS Subcommittee on Industrial @entity2 .

answer: @entity2


abstract: BACKGROUND: Autologous fat injection for breast augmentation has been disputed with regard to its complications for many years, especially regarding calcifications, most of which present with benign features. In previous studies, @entity4 were not observed after fat injection for breast augmentation, which are usually regarded as malignant calcifications. METHODS: From July of 1999 to December of 2009, autologous fat injection for breast augmentation was performed for both breasts in 48 @entity1 . Eight @entity1 with @entity4 found by mammography after surgery were analyzed retrospectively. For the nonpalpable breast lesions in three @entity1 , the @entity4 were resected with the help of needle localized breast biopsy. The palpable lump, including @entity4 , was resected 1 cm away from its border in the other @entity1 . All of the specimens were submitted to pathologic examination. RESULTS: The digitized mammographic films of eight of 48 @entity1 (16.7 percent) showed @entity4 after autologous fat injection, which were highly suspected of being @entity0 microcalcifications, whereas all pathologic examinations indicated fat @entity3 . CONCLUSIONS: Clustered microcalcifications can be found after autologous fat injection for breast augmentation, which cannot be distinguished from @entity2 . The mammographic confusion constitutes the problem rather than the success of the procedure itself, and the method should continue to be prohibited.

title: Clinical analyses of XXXX after autologous fat injection for breast augmentation.

answer: @entity4


abstract: Our previously published clinical results suggest that the variations in serum alkaline DNase activity (SADA) could be a reliable marker for the therapeutic monitoring of different @entity0 @entity1 . The aim of the study documented in this was to determine SADA variations in 27 @entity0 suffering from @entity3 (Hodgkin's and non-Hodgkin's). @entity0 continued to be observed after therapy. The blood samples were collected before treatment (Time 0), during several days from the onset of each treatment (Phase I), and weeks after the last therapy (Phase II). A decrease in the serum alkaline DNase activity during the first treatment indicates a good clinical response; no decrease indicates a nonresponse to treatment (Phase I). The Phase II data can be used to predict the long-term evolution of the disease. In @entity0 who respond to therapy three types of variations of SADA are observed during this phase. A progressive regain of SADA up to a value exceeding the level of initial value (T0) correlates with a complete remission. An incomplete regain of activity corresponds to a partial remission. No regain of SADA precedes @entity2 .

title: Variations in serum alkaline DNase activity. A new means for therapeutic monitoring of XXXX .

answer: @entity3


abstract: @entity0 - @entity1 oxidoreductase operates by a classic ping-pong mechanism with a single site for all substrates: @entity0 , @entity1 , @entity6 and @entity4 . The Km values for these substrates were determined. The values of kcat are 200 s-1 and 0.8 s-1 for the forward and reverse directions respectively. The overall catalytic process consists of two half-reactions with alternate reduction of @entity2 + and oxidation of @entity2 tightly bound to the enzyme. Reduction of enzyme- @entity2 + by @entity0 and oxidation of enzyme- @entity2 by @entity6 involve single first-order processes. The values of the rate constants at saturating substrate are 2100 s-1 and 8 s-1 respectively; @entity5 isotope effects indicate that these are for the @entity3 transfer step. Oxidation of enzyme- @entity2 by @entity1 is first order with a limiting rate constant of at least 430 s-1. The reaction of enzyme- @entity2 + with @entity4 is biphasic, with rate constants for both phases less than 1 s-1. This behaviour is explained by a mechanism in which the slow cyclisation of the acyclic form of @entity1 follows its dissociation from the enzyme. The rate-determining steps for the overall reaction are probably dissociation of @entity6 in the forward direction and @entity3 transfer from @entity4 to enzyme-bound @entity2 + in the reverse direction.

title: The kinetics of @entity0 - XXXX oxidoreductase from Zymomonas mobilis.

answer: @entity1


abstract: @entity0 - @entity1 oxidoreductase operates by a classic ping-pong mechanism with a single site for all substrates: @entity0 , @entity1 , @entity6 and @entity4 . The Km values for these substrates were determined. The values of kcat are 200 s-1 and 0.8 s-1 for the forward and reverse directions respectively. The overall catalytic process consists of two half-reactions with alternate reduction of @entity2 + and oxidation of @entity2 tightly bound to the enzyme. Reduction of enzyme- @entity2 + by @entity0 and oxidation of enzyme- @entity2 by @entity6 involve single first-order processes. The values of the rate constants at saturating substrate are 2100 s-1 and 8 s-1 respectively; @entity5 isotope effects indicate that these are for the @entity3 transfer step. Oxidation of enzyme- @entity2 by @entity1 is first order with a limiting rate constant of at least 430 s-1. The reaction of enzyme- @entity2 + with @entity4 is biphasic, with rate constants for both phases less than 1 s-1. This behaviour is explained by a mechanism in which the slow cyclisation of the acyclic form of @entity1 follows its dissociation from the enzyme. The rate-determining steps for the overall reaction are probably dissociation of @entity6 in the forward direction and @entity3 transfer from @entity4 to enzyme-bound @entity2 + in the reverse direction.

title: The kinetics of XXXX - @entity1 oxidoreductase from Zymomonas mobilis.

answer: @entity0


abstract: @entity7 secretion is tightly regulated by extracellular @entity3 ([ @entity0 ]e) and in turn regulates @entity3 homeostasis through its action on target tissues. We investigated the mechanism and physiological significance of intracellular @entity3 ([ @entity0 ]i) levels in relation to the secretion of @entity7 in single @entity2 parathyroid cells. [ @entity0 ]i was recorded using digital imaging microscopy, and secretion of @entity7 was correlated in the same cell using the reverse hemolytic plaque assay. In individual parathyroid cells, oscillations of [ @entity0 ]i were present in response to specific stimuli. Like secretory activity, response to [ @entity0 ]e concentrations was heterogeneous. Oscillations of [ @entity0 ]i occurred spontaneously in 22% of cells at inhibitory concentrations of [ @entity0 ]e. Oscillations were present only in high [ @entity0 ]e (> or = 1.8 mM) and not noted at lower concentrations of [ @entity0 ]e. The interval and amplitude of [ @entity0 ]i oscillations were 42 +/- 2 sec, and 20 +/- 1 nM (mean +/- SE), respectively. Oscillations were rapidly abolished when [ @entity0 ]e was removed by EGTA, and this effect was reversible. Addition of Mg2+ or polycationic antibiotics such as @entity6 resulted in an [ @entity0 ]i spike, but oscillations were absent. @entity5 , which blocks @entity0 influx through @entity3 channels in various cells, rarely caused oscillations even in the presence of high concentrations of [ @entity0 ]e. To test the role of @entity1 in [ @entity0 ]i oscillations, we added the beta-agonist @entity4 . The addition of @entity4 , however, did not cause oscillations. The number of cells that released @entity7 was significantly lower in cells with oscillations compared with cells without oscillations. We suggest that spontaneous [ @entity0 ]i oscillations are due to the influx of [ @entity0 ]e through ion channels rather than release from [ @entity0 ]i stores and may be a specific intracellular signal associated with inhibition of @entity7 secretion.

title: Spontaneous oscillations of intracellular @entity3 in single XXXX parathyroid cells may be associated with the inhibition of parathyroid hormone secretion.

answer: @entity2


abstract: @entity7 secretion is tightly regulated by extracellular @entity3 ([ @entity0 ]e) and in turn regulates @entity3 homeostasis through its action on target tissues. We investigated the mechanism and physiological significance of intracellular @entity3 ([ @entity0 ]i) levels in relation to the secretion of @entity7 in single @entity2 parathyroid cells. [ @entity0 ]i was recorded using digital imaging microscopy, and secretion of @entity7 was correlated in the same cell using the reverse hemolytic plaque assay. In individual parathyroid cells, oscillations of [ @entity0 ]i were present in response to specific stimuli. Like secretory activity, response to [ @entity0 ]e concentrations was heterogeneous. Oscillations of [ @entity0 ]i occurred spontaneously in 22% of cells at inhibitory concentrations of [ @entity0 ]e. Oscillations were present only in high [ @entity0 ]e (> or = 1.8 mM) and not noted at lower concentrations of [ @entity0 ]e. The interval and amplitude of [ @entity0 ]i oscillations were 42 +/- 2 sec, and 20 +/- 1 nM (mean +/- SE), respectively. Oscillations were rapidly abolished when [ @entity0 ]e was removed by EGTA, and this effect was reversible. Addition of Mg2+ or polycationic antibiotics such as @entity6 resulted in an [ @entity0 ]i spike, but oscillations were absent. @entity5 , which blocks @entity0 influx through @entity3 channels in various cells, rarely caused oscillations even in the presence of high concentrations of [ @entity0 ]e. To test the role of @entity1 in [ @entity0 ]i oscillations, we added the beta-agonist @entity4 . The addition of @entity4 , however, did not cause oscillations. The number of cells that released @entity7 was significantly lower in cells with oscillations compared with cells without oscillations. We suggest that spontaneous [ @entity0 ]i oscillations are due to the influx of [ @entity0 ]e through ion channels rather than release from [ @entity0 ]i stores and may be a specific intracellular signal associated with inhibition of @entity7 secretion.

title: Spontaneous oscillations of intracellular XXXX in single @entity2 parathyroid cells may be associated with the inhibition of parathyroid hormone secretion.

answer: @entity3


abstract: To investigate the behaviour of heart rate variability (HRV) with the advancing severity of @entity2 (CHF) we studied 20 normal subjects and 80 @entity1 ( @entity1 ) @entity0 in sinus rhythm. @entity1 @entity0 were selected consecutively in order to form four equal groups of 20 subjects with different degrees of CHF according to the New York Heart Association (NYHA) functional classification. In each subject a 24 h ECG Holter tape was recorded and subsequently analysed to obtain measures of heart rate and HRV. We used several measures of HR and both spectral and non-spectral measures of HRV. Among these we employed the width of the R-R interval distribution over 24 h at three different heights (TV, 10%Var, 50%Var). The @entity1 group showed significantly lower HRV counts and smaller spectral components than controls. However, these differences were due to the presence of CHF rather than to @entity1 . Indeed, a progressive and significant increase in heart rate and a contemporary decrease in HRV was observed with the advancing severity of CHF. Class IV @entity0 had the smallest HR variation; the spectral composition in this group was barely detectable. The decrease in time domain measures of HRV followed the increase in NYHA Class in a progressive and regular pattern, while the low frequency and high frequency spectral power showed the largest reduction from NYHA Class I to NYHA Class II @entity0 . No significant change was demonstrated in NYHA Class I @entity0 as compared to Controls.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Heart rate variability and functional severity of XXXX secondary to @entity1 .

answer: @entity2


abstract: To investigate the behaviour of heart rate variability (HRV) with the advancing severity of @entity2 (CHF) we studied 20 normal subjects and 80 @entity1 ( @entity1 ) @entity0 in sinus rhythm. @entity1 @entity0 were selected consecutively in order to form four equal groups of 20 subjects with different degrees of CHF according to the New York Heart Association (NYHA) functional classification. In each subject a 24 h ECG Holter tape was recorded and subsequently analysed to obtain measures of heart rate and HRV. We used several measures of HR and both spectral and non-spectral measures of HRV. Among these we employed the width of the R-R interval distribution over 24 h at three different heights (TV, 10%Var, 50%Var). The @entity1 group showed significantly lower HRV counts and smaller spectral components than controls. However, these differences were due to the presence of CHF rather than to @entity1 . Indeed, a progressive and significant increase in heart rate and a contemporary decrease in HRV was observed with the advancing severity of CHF. Class IV @entity0 had the smallest HR variation; the spectral composition in this group was barely detectable. The decrease in time domain measures of HRV followed the increase in NYHA Class in a progressive and regular pattern, while the low frequency and high frequency spectral power showed the largest reduction from NYHA Class I to NYHA Class II @entity0 . No significant change was demonstrated in NYHA Class I @entity0 as compared to Controls.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Heart rate variability and functional severity of @entity2 secondary to XXXX .

answer: @entity1


abstract: @entity0 neutrophils harvested from skin chambers containing autologous serum in psoriatic @entity0 were compared with peripheral blood neutrophils by examining migration, phagocytosis, and oxidative activation. Random migration was reduced in exudate cells, whereas the chemotactic response to yeast-activated serum was evident not only in blood neutrophils, but also in exudate cells. The metabolic activation of exudate neutrophils, when stimulated with @entity4 and measured as chemiluminescence, was enhanced by 50-400% compared to blood neutrophils. The chemiluminescence response to @entity3 was on the other hand reduced to 35%. In the phagocytic assay, using C3bi- and IgG-opsonized @entity1 particles, exudate neutrophils from non-psoriatic healthy controls showed enhanced uptake of C3bi-coated @entity1 compared to blood neutrophils. In psoriatics, the blood neutrophils showed enhanced C3bi-mediated phagocytosis compared to non-psoriatic control cells. No further increase in C3bi-mediated phagocytosis was then seen in exudate cells from these patients. IgG-mediated phagocytosis was in contrast to C3bi similar between blood and exudate neutrophils in psoriatics and non-psoriatic controls. These experiments show that during exudation priming of different receptor-mediated processes can occur. However, no significant difference was observed between different functional capacities in exudate neutrophils from @entity2 @entity0 and non-psoriatic controls.

title: Function of exudate neutrophils from skin in XXXX .

answer: @entity2


abstract: Latencies of lateral visually guided saccades were studied in 60 @entity0 without @entity3 who had unilateral focal lesions clearly visible on computed tomographic (CT) scan that were variously located in both cerebral hemispheres. Significantly asymmetrical latencies were found in 29 @entity0 whose lesions had damaged the deep and posterior frontal region near the corpus callosum and/or, just inferior to this region, the anterior part of the internal capsule. In the 31 other @entity0 , including those with lesions of the @entity2 ( @entity2 ), latencies were not significantly asymmetrical and the lesions spared the entire region just described. These topographical features suggest that the asymmetry of latencies is due to damage in a certain portion of the efferent pathways descending from the @entity2 . A significant increase in bilateral latency was observed in most @entity0 whose lesions had damaged the posterior part of the parietal cortex and/or the underlying white matter. The parietal lobe could therefore exert an excitatory bilateral action on the triggering of visually guided saccades, probably mediated via the superior colliculus. A significant decrease in the bilateral or ipsilateral latency was often found in @entity0 whose lesions had damaged the @entity2 or the underlying white matter. The frontal lobe could therefore exert a predominantly inhibitory bilateral action on this triggering, probably also mediated via the superior colliculus. However, an increase in contralateral latency in some @entity0 with @entity1 indicates that the @entity2 also probably have an excitatory action. This action could be transmitted directly (or indirectly via the superior colliculus) to the reticular premotor structures by tracts decussating partly through the corpus callosum.

title: Latencies of visually guided saccades in unilateral XXXX .

answer: @entity1