abstract: OBJECTIVE: To evaluate GH and @entity2 control and @entity1 shrinkage in newly diagnosed @entity0 with @entity3 treated first-line with lanreotide-Autogel (ATG) 120 mg. Design Open, prospective. @entity0 : Twenty-six @entity0 (17 @entity0 , aged 31-70 years): eight enclosed and 12 extrasellar (eight invasive) macroadenomas and six microadenomas (one invasive). ATG 120 mg initially given every 4 weeks for 12 weeks; then intervals between injections increased to every 6 or 8 weeks if GH levels were <or= 2.5 or < 1 microg/l (equal to 6.5 and 2.6 mU/l), respectively. RESULTS: Final dosage was ATG 120 mg every 4 weeks in nine @entity0 (34.6%), every 6 weeks in eight @entity0 (30.8%) and every 8 weeks in the remaining nine @entity0 (34.6%). After 12 months, both GH and @entity2 were controlled in 14 @entity0 (53.8%). The mean @entity1 volume decreased from 1405 +/- 1827 mm(3) at study entry to 960 +/- 1381 mm(3) after 6 months, and 799 +/- 1161 mm(3) after 12 months (P < 0.0001). Overall @entity1 shrinkage was 35.8 +/- 28.1% after 6 months and 48.4 +/- 27.6% after 12 months. After 12 months, 20 @entity0 (76.9%) achieved > 25% @entity1 shrinkage: 12 of 14 with controlled disease (85.7%) and 8 of 12 with noncontrolled disease (66.7%; P = 0.49). Hyperhydrosis, paresthesiae and @entity4 significantly reduced after treatment. No @entity0 withdrew from the study because of adverse events. CONCLUSION: ATG 120 mg in newly diagnosed @entity0 with @entity3 controls GH and @entity2 secretion in 53.8% and induces >or= 25% @entity1 shrinkage in 76.9% during a 12-month period. The treatment was associated with improvement of clinical symptoms and with a good safety profile.

title: Significant XXXX shrinkage after 12 months of lanreotide Autogel-120 mg treatment given first-line in @entity3 .

answer: @entity1


abstract: OBJECTIVE: To evaluate GH and @entity2 control and @entity1 shrinkage in newly diagnosed @entity0 with @entity3 treated first-line with lanreotide-Autogel (ATG) 120 mg. Design Open, prospective. @entity0 : Twenty-six @entity0 (17 @entity0 , aged 31-70 years): eight enclosed and 12 extrasellar (eight invasive) macroadenomas and six microadenomas (one invasive). ATG 120 mg initially given every 4 weeks for 12 weeks; then intervals between injections increased to every 6 or 8 weeks if GH levels were <or= 2.5 or < 1 microg/l (equal to 6.5 and 2.6 mU/l), respectively. RESULTS: Final dosage was ATG 120 mg every 4 weeks in nine @entity0 (34.6%), every 6 weeks in eight @entity0 (30.8%) and every 8 weeks in the remaining nine @entity0 (34.6%). After 12 months, both GH and @entity2 were controlled in 14 @entity0 (53.8%). The mean @entity1 volume decreased from 1405 +/- 1827 mm(3) at study entry to 960 +/- 1381 mm(3) after 6 months, and 799 +/- 1161 mm(3) after 12 months (P < 0.0001). Overall @entity1 shrinkage was 35.8 +/- 28.1% after 6 months and 48.4 +/- 27.6% after 12 months. After 12 months, 20 @entity0 (76.9%) achieved > 25% @entity1 shrinkage: 12 of 14 with controlled disease (85.7%) and 8 of 12 with noncontrolled disease (66.7%; P = 0.49). Hyperhydrosis, paresthesiae and @entity4 significantly reduced after treatment. No @entity0 withdrew from the study because of adverse events. CONCLUSION: ATG 120 mg in newly diagnosed @entity0 with @entity3 controls GH and @entity2 secretion in 53.8% and induces >or= 25% @entity1 shrinkage in 76.9% during a 12-month period. The treatment was associated with improvement of clinical symptoms and with a good safety profile.

title: Significant @entity1 shrinkage after 12 months of lanreotide Autogel-120 mg treatment given first-line in XXXX .

answer: @entity3


abstract: PURPOSE: This retrospective study is an investigation of the relationship between traffic exposure and @entity3 in a previously unstudied geographic area. We hypothesized that, controlling for selected demographic and social factors, exposure to traffic emissions would allow the prediction of hospital utilization for @entity0 with @entity2 . DESIGN: Using hospital and @entity1 ( @entity1 ) records, we investigated the relationship between proximity to major roadways and admissions for @entity2 exacerbations in the Fort Worth metropolitan area, designated as not attaining federal air health standards. The sample included 2,357 @entity0 from 1 to 12 years of age admitted for emergency or inpatient treatment in a 288-bed, nonprofit @entity0 's medical center in Fort Worth, Texas from January 1, 2004 to December 31, 2005. Data were analyzed using GIS mapping and logistic regression. METHODS: Deidentification data were collected from hospital databases after IRB approval and waiver of parental permission or @entity0 consent. Student's t test was used to compare groups with and without primary @entity2 diagnosis on admission in respect to distance from major roadways. Logistic regression was used to model relationships between @entity2 admission and @entity0 ' characteristics, exposure to traffic, and social environment. FINDINGS: Controlling for several demographic factors, @entity2 occurrences were positively related to traffic exposures. On average, @entity0 with @entity2 lived closer to major roadways than did @entity0 who did not have @entity2 . @entity0 with @entity2 also tended to live in neighborhoods with more roads than did those who did not have @entity2 ; 3/4 of the @entity0 admitted for @entity2 during the study period and less than 1/3 of the @entity0 admitted for nonasthma diagnoses lived within 1,500 meters of a major roadway (p=.0001). Controlling for other factors, every meter increase in proximity to major roadways produced 0.1% increase in likelihood of admission. CLINICAL RELEVANCE: Knowledge of risk factors and their relative magnitudes enable nurses to better tailor symptom management for individual @entity0 .

title: Predicting admissions for childhood XXXX based on proximity to major roadways.

answer: @entity2


abstract: PURPOSE: This study aimed to evaluate @entity2 ( @entity2 ) in @entity0 with advanced @entity3 ( @entity3 ) loss using semi-automated kinetic perimetry (SKP). METHODS: Seventy-eight @entity0 with advanced @entity3 caused by @entity4 (31) or @entity7 (19), homonymous @entity3 caused by post-chiasmal lesions (18) and unilateral @entity5 ( @entity5 ) (10) were examined with SKP (Octopus 101 perimeter). One eye in each @entity0 was enrolled. Additionally, VFs in the 10 healthy fellow eyes of the @entity0 with @entity5 were compared with those in the 10 affected eyes. Reaction time was assessed during the SKP session by presenting kinetic stimuli (III4e) with constant angular velocities of 3 degrees /second moving linearly along so-called ' @entity2 vectors' at four different locations inside the III4e isoptre. Each stimulus presentation was repeated four times in randomized order. RESULTS: The geometric mean @entity2 was 794 ms (95% reference interval [RI] 391-1615 ms) in @entity0 with @entity4 , 702 ms (95% RI 306-1608 ms) in @entity0 with @entity7 and 675 ms (95% RI 312-1460 ms) in @entity0 with @entity6 . Increases in @entity2 for every 1 degree of eccentricity were 1%, 0.9% and 0.4%, respectively. The geometric mean @entity2 in the 10 @entity0 with @entity5 was 644 ms in affected eyes and 435 ms in unaffected eyes, reflecting an increase of 51% (95% confidence interval 42-62%). CONCLUSIONS: We found substantial inter-subject variability in @entity2 in @entity0 with advanced @entity3 . It is possible to correct the position of the isoptres by assessing individual @entity2 . There were no relevant differences in @entity2 between the disease groups. Reaction time increases with eccentricity. In @entity1 ( @entity5 ), @entity2 is prolonged, compared with in healthy fellow eyes. However, in clinical routine the @entity2 -related displacement of isoptres is negligible in the vast majority of cases.

title: Reaction time during semi-automated kinetic perimetry (SKP) in @entity0 with advanced XXXX .

answer: @entity3


abstract: PURPOSE: This study aimed to evaluate @entity2 ( @entity2 ) in @entity0 with advanced @entity3 ( @entity3 ) loss using semi-automated kinetic perimetry (SKP). METHODS: Seventy-eight @entity0 with advanced @entity3 caused by @entity4 (31) or @entity7 (19), homonymous @entity3 caused by post-chiasmal lesions (18) and unilateral @entity5 ( @entity5 ) (10) were examined with SKP (Octopus 101 perimeter). One eye in each @entity0 was enrolled. Additionally, VFs in the 10 healthy fellow eyes of the @entity0 with @entity5 were compared with those in the 10 affected eyes. Reaction time was assessed during the SKP session by presenting kinetic stimuli (III4e) with constant angular velocities of 3 degrees /second moving linearly along so-called ' @entity2 vectors' at four different locations inside the III4e isoptre. Each stimulus presentation was repeated four times in randomized order. RESULTS: The geometric mean @entity2 was 794 ms (95% reference interval [RI] 391-1615 ms) in @entity0 with @entity4 , 702 ms (95% RI 306-1608 ms) in @entity0 with @entity7 and 675 ms (95% RI 312-1460 ms) in @entity0 with @entity6 . Increases in @entity2 for every 1 degree of eccentricity were 1%, 0.9% and 0.4%, respectively. The geometric mean @entity2 in the 10 @entity0 with @entity5 was 644 ms in affected eyes and 435 ms in unaffected eyes, reflecting an increase of 51% (95% confidence interval 42-62%). CONCLUSIONS: We found substantial inter-subject variability in @entity2 in @entity0 with advanced @entity3 . It is possible to correct the position of the isoptres by assessing individual @entity2 . There were no relevant differences in @entity2 between the disease groups. Reaction time increases with eccentricity. In @entity1 ( @entity5 ), @entity2 is prolonged, compared with in healthy fellow eyes. However, in clinical routine the @entity2 -related displacement of isoptres is negligible in the vast majority of cases.

title: Reaction time during semi-automated kinetic perimetry (SKP) in XXXX with advanced @entity3 .

answer: @entity0


abstract: OBJECTIVE: To clinically phenotype an inherited @entity4 with peculiar intraretinal @entity6 , cysts, and @entity1 in a 24-year-old female proband and her family. METHODS: Extended family members of the proband underwent dilated fundus examination, optical coherence tomography, and, in selected cases, @entity2 angiography and electroretinography. RESULTS: Seventeen family members, representing 3 generations and ranging in age from 5 to 64 years, were clinically examined. Visual acuities ranged from 20/20 to 20/200. @entity8 and strabismus were frequently present in affected individuals. Consistent with an autosomal dominant pattern of inheritance, 7 family members had multiple central macular cystic spaces and flat, round, densely @entity6 . There were right-angle vessels and @entity9 in the central macula. Two subjects showed evidence of active macular @entity7 with leakage on @entity2 angiography at ages 7 and 24 years, which was responsive to either focal laser or a single injection of bevacizumab. In those cases examined, multifocal electroretinography showed a diminished foveal response. CONCLUSIONS: This spotted @entity4 appears to represent a new @entity3 . Because these @entity0 are at risk for @entity5 , identification of the responsible gene may provide insight into the mechanisms of pathological @entity7 .

title: A new @entity4 with anomalous vascular development, @entity6 , cystic spaces, and XXXX .

answer: @entity7


abstract: OBJECTIVE: To clinically phenotype an inherited @entity4 with peculiar intraretinal @entity6 , cysts, and @entity1 in a 24-year-old female proband and her family. METHODS: Extended family members of the proband underwent dilated fundus examination, optical coherence tomography, and, in selected cases, @entity2 angiography and electroretinography. RESULTS: Seventeen family members, representing 3 generations and ranging in age from 5 to 64 years, were clinically examined. Visual acuities ranged from 20/20 to 20/200. @entity8 and strabismus were frequently present in affected individuals. Consistent with an autosomal dominant pattern of inheritance, 7 family members had multiple central macular cystic spaces and flat, round, densely @entity6 . There were right-angle vessels and @entity9 in the central macula. Two subjects showed evidence of active macular @entity7 with leakage on @entity2 angiography at ages 7 and 24 years, which was responsive to either focal laser or a single injection of bevacizumab. In those cases examined, multifocal electroretinography showed a diminished foveal response. CONCLUSIONS: This spotted @entity4 appears to represent a new @entity3 . Because these @entity0 are at risk for @entity5 , identification of the responsible gene may provide insight into the mechanisms of pathological @entity7 .

title: A new @entity4 with anomalous vascular development, XXXX , cystic spaces, and @entity7 .

answer: @entity6


abstract: OBJECTIVE: To clinically phenotype an inherited @entity4 with peculiar intraretinal @entity6 , cysts, and @entity1 in a 24-year-old female proband and her family. METHODS: Extended family members of the proband underwent dilated fundus examination, optical coherence tomography, and, in selected cases, @entity2 angiography and electroretinography. RESULTS: Seventeen family members, representing 3 generations and ranging in age from 5 to 64 years, were clinically examined. Visual acuities ranged from 20/20 to 20/200. @entity8 and strabismus were frequently present in affected individuals. Consistent with an autosomal dominant pattern of inheritance, 7 family members had multiple central macular cystic spaces and flat, round, densely @entity6 . There were right-angle vessels and @entity9 in the central macula. Two subjects showed evidence of active macular @entity7 with leakage on @entity2 angiography at ages 7 and 24 years, which was responsive to either focal laser or a single injection of bevacizumab. In those cases examined, multifocal electroretinography showed a diminished foveal response. CONCLUSIONS: This spotted @entity4 appears to represent a new @entity3 . Because these @entity0 are at risk for @entity5 , identification of the responsible gene may provide insight into the mechanisms of pathological @entity7 .

title: A new XXXX with anomalous vascular development, @entity6 , cystic spaces, and @entity7 .

answer: @entity4


abstract: A retrospective study of 21 @entity0 with @entity3 who underwent endoscopic thoracoplasty was done. The objective of the study was to report and assess the morbidity and mid term outcomes of video-assisted thoracoplasty in @entity3 . @entity0 with @entity3 often present cosmetic complaints due to their @entity1 . This deformity may still exist after surgical correction of the main scoliotic curve. Endoscopic thoracoplasty has been reported as a safe method in limited cases of @entity3 . Between 2002 and 2004, 21 @entity0 underwent endoscopic anterior release and thoracoplasty for significant rib @entity1 associated with @entity3 . @entity0 were operated on lateral position, with two endoscopic ports. Anterior release and rib resection were performed during the first stage, and instrumented posterior fusion was performed in a second stage. @entity0 were evaluated preoperatively, 1 week after surgery, 6 months after surgery and at their most recent follow-up with clinical and radiological measurement of the @entity1 . The mean age at surgery was 14.9 years old (range 13-17 years). The average Cobb's angle of the main scoliotic curve was 70 degrees (range 60 degrees -85 degrees). Average follow-up was 25 months (range 23-32 months). The mean number of resected ribs was five ribs (range 4-7) and the mean length of the resected rib was 4.2 cm (range 2.2-7 cm). Average operating time of endoscopic thoracoplasty (including anterior release) was 65 min (range 45-108 min). The mean preoperative height of rib @entity1 was 3.6 cm (range 2.5-5.5 cm). It was reduced to 1.5 cm at most recent follow-up. There was no significant @entity2 necessitating medication postoperatively. No complications related to endoscopic anterior release and rib hump resection occurred in the series. Endoscopic thoracoplasty is a safe and reliable technique in @entity3 . If indicated, the anterior release can be performed with video-assistance and the thoracoplasty can be performed on the same stage.

title: Video-assisted thoracoscopic surgery (VATS) for the treatment of scolioticrib XXXX .

answer: @entity1


abstract: It is well recognized that many if not most @entity0 and adolescents attending paediatric rheumatology clinics will have a non-inflammatory origin for their complaints or disorder. Mechanical causes are frequently identified, and @entity7 or @entity9 is increasingly recognized as an aetiological factor in the presentation. Such conditions include 'growing @entity2 ', recurrent @entity6 , anterior knee @entity2 . Studies of significant cohorts of such @entity0 have now been published supporting the link of @entity8 to particular symptom complexes. However, much disagreement remains as to the @entity7 as an aetiogical factor. What seems clear is that not all hypermobile individuals will be symptomatic or indeed possibly have any risk for specific @entity1 in later life. Screening tools such as the Beighton score are likely to be inadequate in many paediatric populations. Along with increasing recognition of these disorders in childhood and adolescence has been the development of a multidisciplinary management approach, which usually involves predominantly allied health professionals such as podiatrists, physiotherapists and occupational therapists. The challenge remains to interpret symptoms correctly as being related to the @entity7 and to predict why such @entity0 become symptomatic. The answer is likely to involve physiological and psychosocial factors. In addition, early identification and modification of risk factors may have major implications for subsequent prevalence of many adult medical disorders such as @entity5 , @entity4 and @entity3 .

title: Hypermobility disorders in XXXX and adolescents.

answer: @entity0


abstract: @entity4 is the most common genetic @entity1 . Affected muscles are characterized by abnormal @entity3 receptor (AChR) clustering. Some studies have suggested that changes in AChR clusters are secondary to degenerative processes. In this study, we demonstrate that AChR @entity5 and @entity1 are separate events. We compared AChR clusters and pathological features in mdx @entity0 (mutated dystrophin) and dko @entity0 (mutated dystrophin and utrophin). AChR clusters were identified by binding with a-bungarotoxin, and pathological features were observed by classical immunohistochemical techniques. AChR clusters in mdx and dko @entity0 were reduced in number and exhibited @entity6 . However, AChR @entity5 was not significantly different in mdx and dko @entity0 , although more severe inflammatory infiltration and degeneration were observed in dko @entity0 . Furthermore, neuronal @entity2 synthase, which interacts with dystrophin to anchor itself at the sarcolemma, was notably reduced in mdx and dko @entity0 . Fragmentation of AChR and @entity1 are separate events, and both are secondary results of destabilization on the sarcolemma and the cytoskeleton.

title: The absence of dystrophin rather than XXXX causes acetylcholine receptor cluster defects in @entity1 .

answer: @entity1


abstract: @entity4 is the most common genetic @entity1 . Affected muscles are characterized by abnormal @entity3 receptor (AChR) clustering. Some studies have suggested that changes in AChR clusters are secondary to degenerative processes. In this study, we demonstrate that AChR @entity5 and @entity1 are separate events. We compared AChR clusters and pathological features in mdx @entity0 (mutated dystrophin) and dko @entity0 (mutated dystrophin and utrophin). AChR clusters were identified by binding with a-bungarotoxin, and pathological features were observed by classical immunohistochemical techniques. AChR clusters in mdx and dko @entity0 were reduced in number and exhibited @entity6 . However, AChR @entity5 was not significantly different in mdx and dko @entity0 , although more severe inflammatory infiltration and degeneration were observed in dko @entity0 . Furthermore, neuronal @entity2 synthase, which interacts with dystrophin to anchor itself at the sarcolemma, was notably reduced in mdx and dko @entity0 . Fragmentation of AChR and @entity1 are separate events, and both are secondary results of destabilization on the sarcolemma and the cytoskeleton.

title: The absence of dystrophin rather than @entity1 causes acetylcholine receptor cluster defects in XXXX .

answer: @entity1


abstract: STUDY DESIGN: Multicenter, prospective study. OBJECTIVES: To assess the occurrence and predictors of return to work after traumatic @entity1 ( @entity1 ). SETTING: Italian rehabilitation centers. METHODS: We evaluated @entity0 previously included in the Italian Group for the Epidemiological Study of @entity1 study. A standardised telephone interview was used to collect data after a mean follow-up of 3.8 years. The main outcome measure was employment at the end of follow-up. RESULTS: A total of 403 @entity0 , 336 @entity0 and 67 @entity0 , with a mean age of 41.8  16.3 years, were included in the follow-up. In all, 42.1% of @entity0 were employed at the moment of the interview, though 62% reported a worsening in their employment level. Predictors of employment were education (P<0.0001), bowel continence (P=0.02), independence in mobility (P=0.0004), ability to drive (P<0.0001), participating in the community (P=0.0001) and ability to live alone (P<0.0001) while age (P<0.0001), being married (P<0.0001), @entity2 (P=0.03), occurrence of recent medical problems (P=0.002), re-hospitalization (P=0.02), presence of architectonic barriers (P=0.009) and having a public welfare subsidy (P<0.0001), predicted unemployment. On the basis of multivariate analysis, younger age, education, absence of @entity2 , ability to drive, ability to live alone, previous employment were independent predictors of employment after @entity1 . Employment at follow-up was related to several indicators of quality of life. CONCLUSION: Employment after @entity1 was rather frequent and was related to several @entity0 characteristics and social factors. Specific interventions on the @entity0 and on the social environment may favor employment after @entity1 and improve quality of life.

title: Occurrence and predictors of employment after traumatic XXXX : the GISEM Study.

answer: @entity1


abstract: The influence of long-term free-air @entity1 fumigation and canopy position on leaf contents of total @entity2 , its redox state, non-structural proteins (NSP), soluble @entity0 compounds, and total soluble @entity3 in old-growth beech (FAGUS SYLVATICA) and spruce (PICEA ABIES) trees were determined over a period of five years. @entity1 fumigation had weak effects on the analysed metabolites of both tree species and significant changes in the contents of total @entity2 , NSP, and soluble @entity3 were observed only selectively. Beech leaves were affected by crown position to a higher extent than spruce needles and exhibited lower contents of total @entity2 and NSP and total soluble @entity3 , but enhanced contents of oxidised @entity2 and @entity0 compounds in the shade compared to the sun crown. Contents of total soluble @entity3 generally were decreased in shade compared to sun needles of spruce trees. Interspecific differences between beech and spruce were more distinct in the sun compared to the shade crown. Contents of total @entity2 were increased whilst contents of @entity0 compounds and total soluble @entity3 were lower in spruce needles compared to beech leaves. The metabolites determined showed individual patterns in the course of the five measurement years. Contents of total @entity2 and its redox state correlated with air temperature and global radiation, indicating an important role for the antioxidant at low temperatures. Correlations of @entity2 with instantaneous @entity1 concentrations seem to be a secondary effect. Differences in proteins and/or @entity0 compounds in the inter-annual course are assumed to be a consequence of alterations in specific N uptake rates.

title: Significance of XXXX exposure for inter-annual differences in primary metabolites of old-growth beech (Fagus sylvatica L.) and Norway spruce (Picea abies L.) trees in a mixed forest stand.

answer: @entity1


abstract: @entity0 is a @entity2 characterized by extraordinary high renal @entity5 clearance and is associated with @entity6 ( @entity6 ). An 18-year-old sumo wrestler developed @entity6 after anaerobic exercise. Several hours after the exercise, he had a @entity3 in the loins with @entity9 , @entity1 , and @entity4 . On admission, his serum @entity5 was decreased despite the elevation of serum @entity8 (9.5 mg/dL). The level of @entity7 kinase was normal and there was no @entity11 or @entity10 . Magnetic resonance imaging showed no significant abnormality. Renal function improved completely within 2 weeks of hydration treatment. After remission, @entity14 became obvious (1.0 mg/dL) from the initial level of @entity5 (6.1 mg/dL) and fractional excretion of @entity5 was 49%. Polymerase chain reaction of a urate anion exchanger known to regulate blood urate level ( @entity12 gene: @entity12 ) demonstrated that homozygous mutations in exon 4 ( @entity13 ). Both parents showed heterozygous mutation of the @entity12 gene, but both siblings showed no mutation. Thus, we describe a Japanese sumo wrestler of @entity0 complicated with anaerobic exercise-induced @entity6 , with definite demonstration of @entity2 in the responsible gene, @entity12 .

title: @entity6 after exercise in a Japanese sumo wrestler with XXXX .

answer: @entity0


abstract: @entity0 is a @entity2 characterized by extraordinary high renal @entity5 clearance and is associated with @entity6 ( @entity6 ). An 18-year-old sumo wrestler developed @entity6 after anaerobic exercise. Several hours after the exercise, he had a @entity3 in the loins with @entity9 , @entity1 , and @entity4 . On admission, his serum @entity5 was decreased despite the elevation of serum @entity8 (9.5 mg/dL). The level of @entity7 kinase was normal and there was no @entity11 or @entity10 . Magnetic resonance imaging showed no significant abnormality. Renal function improved completely within 2 weeks of hydration treatment. After remission, @entity14 became obvious (1.0 mg/dL) from the initial level of @entity5 (6.1 mg/dL) and fractional excretion of @entity5 was 49%. Polymerase chain reaction of a urate anion exchanger known to regulate blood urate level ( @entity12 gene: @entity12 ) demonstrated that homozygous mutations in exon 4 ( @entity13 ). Both parents showed heterozygous mutation of the @entity12 gene, but both siblings showed no mutation. Thus, we describe a Japanese sumo wrestler of @entity0 complicated with anaerobic exercise-induced @entity6 , with definite demonstration of @entity2 in the responsible gene, @entity12 .

title: XXXX after exercise in a Japanese sumo wrestler with @entity0 .

answer: @entity6


abstract: BACKGROUND: Minimal immunosuppression (IS) is desirable in organ transplantation to reduce side effects and to promote the process of tolerance induction. MATERIAL AND METHODS: Between February 2000 and September 2004, 156 adults (>15 years old) receiving a primary liver graft were enrolled in a prospective, randomized, double-blind, placebo-controlled, investigator-driven single-center study comparing @entity3 ( @entity5 )-placebo (PL) and @entity5 -low-dose, short-term (64 days) @entity1 (ST) IS. There were no exclusion criteria at moment of randomization. All @entity0 had a 12-month follow-up (range, 12-84). RESULTS: Three- and 12-month @entity0 survival rates were 93.6% and 87.2% in the @entity5 -PL group and 98.7% and 94.7% in @entity5 -ST group (P = 0.096 and P = 0.093, respectively). Three- and 12-month graft survival rates were 92.3% and 85.9% versus 97.4% and 92.3% (P = 0.14 and 0.13, respectively). By 3 and 12 months, rejection treatment had been given in 20.5% (16 pts) and 23% (18 pts) of @entity5 -PL @entity0 and in 12.7% (10 pts) and 20.5% (16 pts) of @entity5 -ST @entity0 (P = 0.20 and 0.54). @entity2 -resistant rejection (CRR) at 3 and 12 months was recorded in 12.8% (10 pts) of @entity5 -PL @entity0 and 3.8% (3 pts) of @entity5 -ST @entity0 (P = 0.04). When considering the 145 @entity0 transplanted without artificial organ support (n = 145), CRR at 3 and 12 months was recorded in 8.8% (6/68 pts) of @entity5 -PL @entity0 and in 3.9% (3/77 pts) of @entity5 -ST @entity0 (P = 0.22). @entity4 was diagnosed in 1 (1.2%) @entity5 -PL @entity0 and 4 (5.1%) @entity5 -ST @entity0 (P = 0.17). By 1 year, 78.2% (61/78) of @entity5 -PL @entity0 and 82% (64/78) of @entity5 -ST @entity0 were on @entity5 monotherapy (P = 0.54). When considering 67 @entity5 -PL and 74 @entity5 -ST survivors, rates of monotherapy were 91% (61 pts) and 86.5% (64 pts) (P = 0.39). At 1 year, 62.5% (42 pts) of @entity5 -PL survivors and 64.9% (48 pts) of @entity5 -ST survivors were on low-dosage (<6 ng/mL) @entity5 monotherapy (P 0.79). CONCLUSION: @entity5 monotherapy can be achieved safely without compromising graft nor @entity0 survival in a primary, even unselected, adult liver transplant population. The higher incidence of early CRR in the @entity5 -PL group related to the significantly higher number of @entity0 transplanted while being on artificial organ support. In such condition, this monodrug immunosuppressive strategy needs to be adapted. @entity5 monotherapy strategy should lay the basis for further large scale minimization studies in liver transplantation.

title: XXXX monotherapy in liver transplantation: one-year results of a prospective, randomized, double-blind, placebo-controlled study.

answer: @entity3


abstract: Molecular techniques can aid in the classification of Biomphalaria species because morphological differentiation between these species is difficult. Previous studies using phylogeny, morphological and molecular taxonomy showed that some populations studied were Biomphalaria cousini instead of Biomphalaria amazonica. Three different molecular profiles were observed that enabled the separation of B. amazonica from B. cousini. The third profile showed an association between the two and suggested the possibility of hybrids between them. Therefore, the aim of this work was to investigate the hybridism between B. cousini and B. amazonica and to verify if the hybrids are susceptible to @entity0 . Crosses using the albinism factor as a genetic marker were performed, with pigmented B. cousini and albino B. amazonica snails identified by polymerase chain reaction-restriction fragment length polymorphism. This procedure was conducted using B. cousini and B. amazonica of the type locality accordingly to Paraense, 1966. In addition, susceptibility studies were performed using snails obtained from the crosses (hybrids) and three @entity1 strains (LE, SJ, @entity2 ). The crosses between B. amazonica and B. cousini confirmed the occurrence of hybrids. Moreover, hybrids can be considered potential hosts of @entity1 because they are susceptible to LE, SJ and @entity2 strains (4.4%, 5.6% and 2.2%, respectively). These results indicate that there is a risk of introducing schistosomiasis mansoni into new areas.

title: Hybridism between Biomphalaria cousini and Biomphalaria amazonica and its susceptibility to XXXX .

answer: @entity0


abstract: PURPOSE: To compare the usefulness in @entity2 screening of scanning laser polarimetry ( @entity5 -VCC), scanning laser tomography [Heidelberg retina tomograph II (HRT II)], and their combined evaluation. METHODS: In a nonpopulation-based prepublicized trial, self-recruited white @entity0 were screened for @entity2 with @entity5 -VCC, HRT II, and by independent clinical examination. Cases with possible @entity2 as found with any of the screening methods underwent a detailed clinical investigation to verify or exclude @entity2 . RESULTS: Of the 136 attendees 118 @entity0 (218 eyes) successfully underwent the @entity5 -VCC and @entity4 . Twenty-three eyes (11%) of 13 @entity0 had @entity2 . Seventeen of these @entity3 (74%) had early damage. Evaluated separately, the @entity5 -VCC screening test (borderline cases grouped with the normal cases) performed best with 96.8% specificity, 89.5% accuracy, 7.5 positive likelihood ratio (PLR), but with only 23.8% sensitivity. Accuracy and PLR for all HRT parameters were <86.4% and <3.7, respectively. Combining different threshold criteria, for @entity5 -VCC accuracy increased to 90.3% to 90.8% and PLR to 14.0 to 17.7; but for HRT no useful increase was seen (accuracy <86.4% and PLR<4.7 for all combinations). Combination of the best HRT and @entity5 -VCC criteria resulted in a PLR which was increased compared with the HRT combinations, but decreased compared with the @entity5 -VCC combinations (PLR<12.7 for all combinations). CONCLUSIONS: In this white screening population with relatively high risk for mild @entity1 , a combination of different @entity5 -VCC criteria was useful for @entity2 screening; but combinations of HRT criteria or combinations of @entity5 -VCC criteria with HRT criteria were less good for this purpose.

title: Accuracy of scanning laser polarimetry, scanning laser tomography, and their combination in a XXXX screening trial.

answer: @entity2


abstract: Primary percutaneous coronary intervention (PCI) has become the favored reperfusion strategy in acute ST-segment elevation @entity0 . Lower post-PCI myocardial perfusion grade, no-reflow and even drug-eluting stent @entity1 have been related to the presence of intracoronary @entity1 . Adjunctive thrombectomy refers to procedures and devices that remove @entity1 material from the @entity2 , in theory, before distal embolization can occur. There is substantial variability between randomized controlled trials of thrombectomy in primary PCI with regards to tested devices, procedural characteristics, adjuvant medical regimen and examined outcomes. As a general statement, improvements in myocardial perfusion endpoints do not translate into reductions in clinical outcomes. Yet, an increasing number of trials with a longer follow-up reported benefits arising late after the index @entity0 . Simple aspiration catheters may also produce better outcomes than devices that fragment the @entity1 before aspirating debris. Clinical or angiographic variables which best predict benefits from the use of thrombectomy remain to be defined. The aim of this review is to provide perspective on the conclusions of available trials and meta-analysis of adjunctive thrombectomy in acute @entity0 . Targets for future studies are discussed.

title: Adjunctive thrombectomy in primary percutaneous intervention for acute XXXX .

answer: @entity0


abstract: BACKGROUND: Regular exercise has been associated with a 40%-80% reduction in risk for @entity1 in several case-control studies. However, @entity0 experiencing symptoms prior to their diagnosis may be less likely to exercise than healthy controls, thus biasing the observed association. METHODS: Using data collected from the Nurses' Health Study II, a prospective cohort study of premenopausal US nurses that began in 1989, we have attempted to clarify this relation. Data are updated every 2 years with follow-up for these analyses through 2001. In 1989, 1991, and 1997 @entity0 reported average amount of time per week engaging in various physical activities. A metabolic equivalent (MET) score was assigned to each activity, and these were summed to estimate total activity. RESULTS: A total of 102,197 premenopausal @entity0 contributed 996,422 @entity0 -years of follow-up with 2703 cases of laparoscopically confirmed @entity1 . After adjusting for BMI at age 18, current BMI, smoking, parity, @entity2 status, oral contraceptive use, age at menarche, and menstrual cycle length and pattern in college, we observed only a slight reduction in the incidence of @entity1 , comparing the highest level of activity (>or=42 MET hours/week) to the lowest (<3 MET hours/week) (rate ratio = 0.89 [95% confidence interval = 0.77-1.03]). The association was limited to @entity0 with no past or concurrent @entity2 (P = 0.002, test for heterogeneity). No associations were seen with inactivity. CONCLUSIONS: In this first prospective assessment, we did not find evidence of the strong inverse association previously reported, although we cannot rule out a modest inverse association.

title: Adult physical activity and XXXX risk.

answer: @entity1


abstract: @entity2 ( @entity2 ) are remote effects of @entity1 that are not caused by invasion of the @entity1 or its metastases. Immunologic factors appear important in the pathogenesis of @entity2 because antineuronal autoantibodies and T-cell responses against nervous system antigens have been defined for many of these disorders. The immunologic response is elicited by the ectopic expression of neuronal antigens by the @entity1 . Expression of these so-called "onconeural" antigens is limited to the @entity1 and the nervous system and sometimes also the testis. At the time of presentation of the neurological symptoms, most @entity0 have not yet been diagnosed with @entity1 . Detection of @entity3 antibodies is extremely helpful in diagnosing an otherwise unexplained and often rapidly progressive @entity2 as @entity3 . In addition, the @entity3 antibodies may also direct the search for an underlying @entity1 . On the other hand, in @entity0 known to have @entity1 , the presentation of a @entity2 may herald recurrence of the @entity1 or a second @entity1 . The number of @entity3 antibodies is still growing, and at least seven of these can now be considered well characterized. Based on the clinical syndrome, the type of antibody, and the presence or absence of @entity1 , @entity0 are classified as having a "definite" or "possible" @entity2 . Despite the presumed autoimmune etiology of @entity2 , the results of various forms of immunotherapy have been disappointing, with some exceptions. Rapid detection and immediate treatment of the underlying @entity1 appears to offer the best chance of stabilizing the @entity0 and preventing further @entity2 .

title: Managing @entity3 XXXX .

answer: @entity2


abstract: @entity2 ( @entity2 ) are remote effects of @entity1 that are not caused by invasion of the @entity1 or its metastases. Immunologic factors appear important in the pathogenesis of @entity2 because antineuronal autoantibodies and T-cell responses against nervous system antigens have been defined for many of these disorders. The immunologic response is elicited by the ectopic expression of neuronal antigens by the @entity1 . Expression of these so-called "onconeural" antigens is limited to the @entity1 and the nervous system and sometimes also the testis. At the time of presentation of the neurological symptoms, most @entity0 have not yet been diagnosed with @entity1 . Detection of @entity3 antibodies is extremely helpful in diagnosing an otherwise unexplained and often rapidly progressive @entity2 as @entity3 . In addition, the @entity3 antibodies may also direct the search for an underlying @entity1 . On the other hand, in @entity0 known to have @entity1 , the presentation of a @entity2 may herald recurrence of the @entity1 or a second @entity1 . The number of @entity3 antibodies is still growing, and at least seven of these can now be considered well characterized. Based on the clinical syndrome, the type of antibody, and the presence or absence of @entity1 , @entity0 are classified as having a "definite" or "possible" @entity2 . Despite the presumed autoimmune etiology of @entity2 , the results of various forms of immunotherapy have been disappointing, with some exceptions. Rapid detection and immediate treatment of the underlying @entity1 appears to offer the best chance of stabilizing the @entity0 and preventing further @entity2 .

title: Managing XXXX @entity2 .

answer: @entity3


abstract: PURPOSE: Defective DNA mismatch repair is commonly present in sporadic manifestations of @entity4 . The pathognomonic molecular manifestation of this repair defect is @entity3 ( @entity3 ). Here, we test the hypothesis that @entity3 predicts the clinicopathologic features of @entity4 . @entity0 AND METHODS: A retrospective cohort of 473 @entity0 treated for @entity4 at this institution was identified. All cases were reviewed by a gynecologic pathologist, and clinical information was abstracted from medical records. Using consensus criteria, DNA samples from nontumor and @entity2 tissue pairs were genotyped for @entity3 . Associations between @entity3 status and pathologic and clinical variables were assessed. RESULTS: Ninety-three (20%) of 473 @entity2 were @entity3 +. In the @entity3 + @entity2 group compared with the @entity2 group, the proportion of advanced compared with early-stage @entity2 was higher (92% v 81%; P = .01), as was the proportion of @entity2 of endometrioid compared with nonendometrioid histologic subtype (94% v 23%; P = .001), and the proportion of @entity2 with @entity1 compared with those with none (92% v 78%; P = .01). By multivariate analyses, disease-free survival (hazard ratio, 0.3; 95% CI, 0.2 to 0.7) and disease-specific survival (hazard ratio, 0.3; 95% CI, 0.1 to 0.8) were significantly improved in @entity0 with @entity3 + @entity2 . CONCLUSION: In @entity4 , the presence of @entity3 was independently associated with a more favorable clinical outcome.

title: Clinicopathologic significance of defective DNA mismatch repair in XXXX .

answer: @entity4


abstract: PURPOSE: We report surgical results of @entity1 associated with @entity2 . MATERIALS AND METHODS: We report on morbidity and mortality, and we analyze the risk factors for them and the prognostic factors for overall survival of @entity0 without mortality. RESULTS: Morbidity developed in 13 of the 38 @entity0 (34.2%). Mortality rate was 10.5%. Hemoglobin concentration before surgery and predicted postoperative forced expiratory volume in one second were significantly low in @entity0 with morbidity and mortality based on the univariate analyses. Predicted postoperative forced expiratory volume in one second was a significant risk factor for morbidity based on a multivariate analysis. Poor prognostic factors for overall survival were serum albumin concentration, hemoglobin concentration, and performance status before surgery, combined resection, and pathological stage. Serum albumin concentration was significant based on a multivariate analysis. CONCLUSIONS: Morbidity and mortality are high in @entity0 with @entity1 associated with @entity2 . Morbidity demonstrates significant association with low predicted postoperative forced expiratory volume in one second and hemoglobin concentration, indicating the need for preoperative transfusion in severe @entity3 or bronchoplasty if possible. Poor nutritional state before surgery possibly derived from cachexia may influence not only morbidity and mortality, but also prognosis.

title: Surgical results of XXXX associated with @entity2 .

answer: @entity1


abstract: PURPOSE: We report surgical results of @entity1 associated with @entity2 . MATERIALS AND METHODS: We report on morbidity and mortality, and we analyze the risk factors for them and the prognostic factors for overall survival of @entity0 without mortality. RESULTS: Morbidity developed in 13 of the 38 @entity0 (34.2%). Mortality rate was 10.5%. Hemoglobin concentration before surgery and predicted postoperative forced expiratory volume in one second were significantly low in @entity0 with morbidity and mortality based on the univariate analyses. Predicted postoperative forced expiratory volume in one second was a significant risk factor for morbidity based on a multivariate analysis. Poor prognostic factors for overall survival were serum albumin concentration, hemoglobin concentration, and performance status before surgery, combined resection, and pathological stage. Serum albumin concentration was significant based on a multivariate analysis. CONCLUSIONS: Morbidity and mortality are high in @entity0 with @entity1 associated with @entity2 . Morbidity demonstrates significant association with low predicted postoperative forced expiratory volume in one second and hemoglobin concentration, indicating the need for preoperative transfusion in severe @entity3 or bronchoplasty if possible. Poor nutritional state before surgery possibly derived from cachexia may influence not only morbidity and mortality, but also prognosis.

title: Surgical results of @entity1 associated with XXXX .

answer: @entity2


abstract: AIM: @entity2 are an important cause of morbidity and mortality in @entity4 ( @entity4 ) @entity0 . The purpose of this study was to evaluate the predominance of @entity6 and @entity8 ( @entity8 ) in a group of @entity0 subject to dialysis compared with a control group. METHODS: It is a control-case study performed on @entity0 at different hemodialysis facilities; the exams were carried out in ambulatory care. Two groups of @entity0 were examined, the first group was made up of 40 dialysis @entity0 (46.6% @entity0 , average age 58.8), the second was the control group made up of 58 subjects matched by age, sex, arterial pressure, presence of @entity1 and smoking habits. All @entity0 underwent an Eco-Color Doppler exam on the over aortal trunks and lower extremities and had their Ankle-Brakial-Index (ABI) measured. Carotid @entity7 was considered only if equal or over 50%. RESULTS: Twenty percent of dialysis @entity0 showed @entity6 ( @entity6 ) versus 12% in the control group, with an OR of 7.9 (CI 95% 1.3-47.7) adjusted to sex, age and @entity3 . The ultrasound picture of the lesions showed large amounts of @entity5 deposits. Predominance of @entity8 in dialysis @entity0 was 20% versus 9% in the control group. In dialysis @entity0 the OR adjusted to age, sex and arterial pressure was 6.3 (CI 95%, 1.2-32.6). CONCLUSION: The ultrasound picture of the lesions showed mainly underpopliteal lesions with ''rosary bead'' calcifications. In @entity1 @entity0 the OR was 7.6 (CI 95% 1.4-46.3).

title: @entity8 and XXXX in @entity4 : a case-control study.

answer: @entity6


abstract: AIM: @entity2 are an important cause of morbidity and mortality in @entity4 ( @entity4 ) @entity0 . The purpose of this study was to evaluate the predominance of @entity6 and @entity8 ( @entity8 ) in a group of @entity0 subject to dialysis compared with a control group. METHODS: It is a control-case study performed on @entity0 at different hemodialysis facilities; the exams were carried out in ambulatory care. Two groups of @entity0 were examined, the first group was made up of 40 dialysis @entity0 (46.6% @entity0 , average age 58.8), the second was the control group made up of 58 subjects matched by age, sex, arterial pressure, presence of @entity1 and smoking habits. All @entity0 underwent an Eco-Color Doppler exam on the over aortal trunks and lower extremities and had their Ankle-Brakial-Index (ABI) measured. Carotid @entity7 was considered only if equal or over 50%. RESULTS: Twenty percent of dialysis @entity0 showed @entity6 ( @entity6 ) versus 12% in the control group, with an OR of 7.9 (CI 95% 1.3-47.7) adjusted to sex, age and @entity3 . The ultrasound picture of the lesions showed large amounts of @entity5 deposits. Predominance of @entity8 in dialysis @entity0 was 20% versus 9% in the control group. In dialysis @entity0 the OR adjusted to age, sex and arterial pressure was 6.3 (CI 95%, 1.2-32.6). CONCLUSION: The ultrasound picture of the lesions showed mainly underpopliteal lesions with ''rosary bead'' calcifications. In @entity1 @entity0 the OR was 7.6 (CI 95% 1.4-46.3).

title: XXXX and @entity6 in @entity4 : a case-control study.

answer: @entity8


abstract: AIM: @entity2 are an important cause of morbidity and mortality in @entity4 ( @entity4 ) @entity0 . The purpose of this study was to evaluate the predominance of @entity6 and @entity8 ( @entity8 ) in a group of @entity0 subject to dialysis compared with a control group. METHODS: It is a control-case study performed on @entity0 at different hemodialysis facilities; the exams were carried out in ambulatory care. Two groups of @entity0 were examined, the first group was made up of 40 dialysis @entity0 (46.6% @entity0 , average age 58.8), the second was the control group made up of 58 subjects matched by age, sex, arterial pressure, presence of @entity1 and smoking habits. All @entity0 underwent an Eco-Color Doppler exam on the over aortal trunks and lower extremities and had their Ankle-Brakial-Index (ABI) measured. Carotid @entity7 was considered only if equal or over 50%. RESULTS: Twenty percent of dialysis @entity0 showed @entity6 ( @entity6 ) versus 12% in the control group, with an OR of 7.9 (CI 95% 1.3-47.7) adjusted to sex, age and @entity3 . The ultrasound picture of the lesions showed large amounts of @entity5 deposits. Predominance of @entity8 in dialysis @entity0 was 20% versus 9% in the control group. In dialysis @entity0 the OR adjusted to age, sex and arterial pressure was 6.3 (CI 95%, 1.2-32.6). CONCLUSION: The ultrasound picture of the lesions showed mainly underpopliteal lesions with ''rosary bead'' calcifications. In @entity1 @entity0 the OR was 7.6 (CI 95% 1.4-46.3).

title: @entity8 and @entity6 in XXXX : a case-control study.

answer: @entity4


abstract: Our aim was to investigate the efficacy, @entity3 , and drug discontinuation in @entity0 with @entity4 ( @entity4 ) treated with infliximab. Thirty-five @entity0 with @entity4 , who were enrolled between June 2001 and December 2002 were treated with infliximab. All @entity0 fulfilled the New York revised criteria for @entity4 and had @entity2 . Infliximab (5 mg/kg weight), was given intravenously at weeks 0, 2, 6, and every 8 weeks thereafter. If this failed to give an acceptable treatment response, the interval was shortened to 6 or 4 weeks. The @entity0 were followed-up at predefined times according to a standardized protocol. Data concerning infliximab efficacy, tolerability, adverse events, interval, and drug discontinuation were all recorded. Clinical improvement according to the Bath @entity4 Activity Index (BASDAI) 50% and the @entity4 Assessment Study group (ASAS) 40%, and ASAS 5/6 response criteria were recorded. Infliximab treatment resulted in a rapid improvement in the BASDAI and ASAS scores in the first year of the treatment, which sustained throughout the fourth year. More specifically, after the third year of treatment 17/35 (48.6%) of @entity0 achieved BASDAI 50% response criteria, 19/35 (54.3%) attained the ASAS 40% and 15/35 (42.9%) reached the ASAS 5/6. After the fourth year of treatment BASDAI 50% was reached by 17/35 (48.6%) of @entity0 , ASAS 40% by 17/35 (48.6%), while ASAS 5/6 was attained by 15/35 (42.9%). The clinical improvement was associated with the reduction of acute phase reactants as measured by @entity5 levels. After the first year of treatment, the "survival rate" of infliximab was 94.3%, after the second year was 91.4%, after the third year was 85.7% and even after 4 years of treatment still maintained high 77.9%. Six (17.1%) @entity0 were withdrawn during the observational period. Three because of lack of efficacy, two because of @entity1 and one lost from follow-up. Infliximab was effective, safe, and well tolerated in @entity0 with @entity4 . The clinical response was maintained for a period of 4 years and over, with infliximab survival of 77.9%.

title: Persistent clinical response of infliximab treatment, over a 4-year period in XXXX .

answer: @entity4


abstract: The objective of this study was to examine the differences in oscillatory brain dynamics in @entity1 ( @entity1 ) according to age at onset using quantitative electroencephalography (EEG). We examined resting state electroencephalograms of 320 probable @entity1 @entity0 and 246 controls, both categorized into a young ( <= 65 years) and old (> 65 years) group. Relative power in 4 different frequency bands was calculated. The effect of age on global and regional relative power was examined. Globally, young @entity1 @entity0 showed lower alpha- and higher delta-power than old @entity1 @entity0 . Regional analysis showed that these differences were most pronounced in the parieto-occipital region. Young @entity1 @entity0 had lower beta- and higher theta-power than old @entity0 in all but the temporal regions. In controls, there was no age effect on global relative power in any frequency band. Young @entity1 @entity0 present with more severe slowing of spontaneous oscillatory activity than old @entity1 @entity0 , which is most pronounced in the posterior brain areas. This finding supports the hypothesis that early onset @entity1 presents with a distinct endophenotype.

title: Young Alzheimer XXXX show distinct regional changes of oscillatory brain dynamics.

answer: @entity0


abstract: The parasitic ciliate @entity6 infests all species of freshwater fish and can cause severe economic losses in fish breeding. The most effective treatment, @entity5 green, has been banned in Europe and North America for use in food fish production. @entity2 ( @entity3 ) was found to be toxic to @entity6 theronts at low concentrations. @entity6 -infested @entity4 were exposed to 1 mg/l @entity3 in a dynamic exposure by means of peristaltic pumps. Five days after @entity0 , gills, tail fins, and skin below the dorsal fin were observed microscopically for @entity6 abundance. After @entity3 exposure, @entity3 -treated fish showed lower @entity0 of @entity6 in all investigated tissues than the unexposed control fish. The @entity0 increased in the control group whereas the @entity0 in the @entity3 -exposed groups significantly decreased (p = 0.0083, Bonferroni correction). The fish in the two exposure groups showed a slight reinfestation with @entity6 . This might be caused by a @entity1 degradation (hydrolysis) and/or reduction of the delivered @entity3 concentration. Thus, @entity3 concentrations were possibly too low to be effective on the released trophonts and/or the infective theronts. This hypothesis is corroborated by the fact that the @entity6 in the gills, skin, and fins of the @entity3 -exposed @entity4 were in an early developmental stage.

title: Evaluation of continuous 4-day exposure to @entity2 as a treatment for XXXX .

answer: @entity6


abstract: The parasitic ciliate @entity6 infests all species of freshwater fish and can cause severe economic losses in fish breeding. The most effective treatment, @entity5 green, has been banned in Europe and North America for use in food fish production. @entity2 ( @entity3 ) was found to be toxic to @entity6 theronts at low concentrations. @entity6 -infested @entity4 were exposed to 1 mg/l @entity3 in a dynamic exposure by means of peristaltic pumps. Five days after @entity0 , gills, tail fins, and skin below the dorsal fin were observed microscopically for @entity6 abundance. After @entity3 exposure, @entity3 -treated fish showed lower @entity0 of @entity6 in all investigated tissues than the unexposed control fish. The @entity0 increased in the control group whereas the @entity0 in the @entity3 -exposed groups significantly decreased (p = 0.0083, Bonferroni correction). The fish in the two exposure groups showed a slight reinfestation with @entity6 . This might be caused by a @entity1 degradation (hydrolysis) and/or reduction of the delivered @entity3 concentration. Thus, @entity3 concentrations were possibly too low to be effective on the released trophonts and/or the infective theronts. This hypothesis is corroborated by the fact that the @entity6 in the gills, skin, and fins of the @entity3 -exposed @entity4 were in an early developmental stage.

title: Evaluation of continuous 4-day exposure to XXXX as a treatment for @entity6 .

answer: @entity2


abstract: Mountain hiking is associated with a death rate of about 4 deaths per 100,000 hikers annually. About 50 % of all fatalities during mountain hiking are @entity10 ( @entity10 ). But there are only few data available regarding risk factors and triggers associated with @entity11 during mountain hiking. Thus, a case-control analysis between @entity0 who died suddenly during mountain hiking and randomly selected controls was carried out. Risk factor profiles of 179 males over the age of 34 who suffered @entity11 during mountain hiking were compared to those of 537 matched controls. Hikers who died suddenly during mountain hiking were much more likely to have had a prior MI (17% vs. 0.9%; p < 0.001), known @entity6 ( @entity6 ) without prior MI (17 % vs. 4%; p < 0.001), @entity1 (6% vs. 1 %; p < 0.001), @entity9 (54 % vs. 20%; p < 0.001), and were less engaged in regular mountain sports activities (31% vs. 58%; p < 0.001) compared to hikers from the control group. Based on the reported relationship between traditional risk factors and coronary plaque morphology, acute @entity5 with @entity7 formation and subsequent lethal @entity8 may be assumed to be a dominant mechanism precipitating @entity11 during hiking. In contrast, in skiers especially non-occlusive plaques may precipitate @entity3 leading to an imbalance between @entity2 demand and supply and subsequent lethal @entity8 . As preventive measures recommended to hikers at risk, adaptation to regular mountain sports activities by an adequate training program and pharmacological interventions, e.g. lipid lowering drugs, @entity4 , and beta-blockers, should be considered.

title: Risk factor profile for XXXX during mountain hiking.

answer: @entity10


abstract: BACKGROUND: Although congenital @entity4 dilatation is frequently associated with @entity3 , conventional cholangiography often does not demonstrate small @entity1 . This is the first prospective study of the value of intraductal ultrasonography (US) in the examination of the extrahepatic bile ducts in @entity0 with congenital @entity4 dilatation. METHODS: Intraductal US via a transpapillary route was used in consecutive @entity0 with congenital @entity4 dilatation. A 2.0 mm diameter, 20 MHz frequency catheter probe was used. The images were correlated with the results of histologic examination of the resection specimens. RESULTS: Intraductal US was performed successfully via the transpapillary route in 8 of 10 @entity0 . In the other 2 @entity0 , the percutaneous transhepatic route was used. In the 6 @entity0 with cylindrical dilatation, intraductal US demonstrated the entire extrahepatic @entity4 . In 1 @entity0 , it showed a @entity4 cancer not demonstrated by cholangiography. In 2 of the 4 @entity0 with @entity2 , intraductal US did not demonstrate the entire extrahepatic @entity4 because of the low penetration depth of the probe. Percutaneous transhepatic cholangioscopy was required in these @entity0 . CONCLUSIONS: Intraductal US is useful for demonstrating @entity1 in the extrahepatic bile ducts in @entity0 with @entity2 .

title: Preoperative assessment of congenital XXXX dilatation using intraductal US.

answer: @entity4


abstract: BACKGROUND: Like menopause, during complete lactation, circulating @entity1 concentrations are markedly reduced, resulting in amplified bone resorption. AIM OF STUDY: To investigate the effects of soy @entity7 , common dietary components used to mitigate the @entity3 of menopause, on the @entity3 associated with lactation. METHODS: Lactating @entity0 were randomized to one of four diets supplemented with different levels of soy @entity7 (0, 2, 4, 8 mg aglycone @entity5 /g protein). Milk was collected from all dams between days 12 and 15 of lactation and was analyzed for @entity2 , @entity6 and @entity4 concentrations. Serum and bones from half of the animals from each diet group were taken at weaning and from the remaining half at 4 weeks post-weaning. Bones underwent histomorphometric analysis and serum was used for @entity4 determinations. RESULTS: Serum @entity4 and milk concentrations reflected dietary @entity5 dose. @entity5 intake had no effect on any of the bone changes associated with lactation or recovery. Milk @entity2 and mineral concentrations were unaffected by dietary @entity7 . CONCLUSIONS: Consumption of soy @entity7 , in levels that can be readily attained through soy foods, have neither protective effects on bone nor deleterious effects on milk quality or quantity during lactation.

title: Effects of soy @entity5 consumption on bone structure and milk mineral concentration in a @entity0 model of lactation-associated XXXX .

answer: @entity3


abstract: BACKGROUND: Like menopause, during complete lactation, circulating @entity1 concentrations are markedly reduced, resulting in amplified bone resorption. AIM OF STUDY: To investigate the effects of soy @entity7 , common dietary components used to mitigate the @entity3 of menopause, on the @entity3 associated with lactation. METHODS: Lactating @entity0 were randomized to one of four diets supplemented with different levels of soy @entity7 (0, 2, 4, 8 mg aglycone @entity5 /g protein). Milk was collected from all dams between days 12 and 15 of lactation and was analyzed for @entity2 , @entity6 and @entity4 concentrations. Serum and bones from half of the animals from each diet group were taken at weaning and from the remaining half at 4 weeks post-weaning. Bones underwent histomorphometric analysis and serum was used for @entity4 determinations. RESULTS: Serum @entity4 and milk concentrations reflected dietary @entity5 dose. @entity5 intake had no effect on any of the bone changes associated with lactation or recovery. Milk @entity2 and mineral concentrations were unaffected by dietary @entity7 . CONCLUSIONS: Consumption of soy @entity7 , in levels that can be readily attained through soy foods, have neither protective effects on bone nor deleterious effects on milk quality or quantity during lactation.

title: Effects of soy XXXX consumption on bone structure and milk mineral concentration in a @entity0 model of lactation-associated @entity3 .

answer: @entity5


abstract: BACKGROUND: Like menopause, during complete lactation, circulating @entity1 concentrations are markedly reduced, resulting in amplified bone resorption. AIM OF STUDY: To investigate the effects of soy @entity7 , common dietary components used to mitigate the @entity3 of menopause, on the @entity3 associated with lactation. METHODS: Lactating @entity0 were randomized to one of four diets supplemented with different levels of soy @entity7 (0, 2, 4, 8 mg aglycone @entity5 /g protein). Milk was collected from all dams between days 12 and 15 of lactation and was analyzed for @entity2 , @entity6 and @entity4 concentrations. Serum and bones from half of the animals from each diet group were taken at weaning and from the remaining half at 4 weeks post-weaning. Bones underwent histomorphometric analysis and serum was used for @entity4 determinations. RESULTS: Serum @entity4 and milk concentrations reflected dietary @entity5 dose. @entity5 intake had no effect on any of the bone changes associated with lactation or recovery. Milk @entity2 and mineral concentrations were unaffected by dietary @entity7 . CONCLUSIONS: Consumption of soy @entity7 , in levels that can be readily attained through soy foods, have neither protective effects on bone nor deleterious effects on milk quality or quantity during lactation.

title: Effects of soy @entity5 consumption on bone structure and milk mineral concentration in a XXXX model of lactation-associated @entity3 .

answer: @entity0


abstract: BACKGROUND: Neonatal hyperinsulinemic @entity7 is often resistant to medical therapy and is often treated with near-total pancreatectomy. However, the @entity4 may be focal and treatable by partial pancreatic resection. METHODS: We studied 52 neonates with @entity6 who were treated surgically. The type and location of the @entity4 were determined by preoperative pancreatic catheterization and intraoperative histologic studies. Partial pancreatectomy was performed in @entity0 with focal lesions, and near-total pancreatectomy was performed in those with @entity2 . The postoperative outcome was determined by measurements of plasma @entity3 and glycosylated hemoglobin and by oral @entity3 -tolerance tests. RESULTS: Thirty neonates had diffuse beta-cell hyperfunction, and 22 had focal @entity5 . Among the latter, the lesions were in the head of the pancreas in nine, the isthmus in three, the body in eight, and the tail in two. The clinical manifestations were similar in both groups. The @entity0 with focal lesions had no symptoms of @entity7 and had normal preprandial and postprandial plasma @entity3 and glycosylated hemoglobin values and normal results on oral @entity3 -tolerance tests after partial pancreatectomy (performed in 19 of 22 neonates). By contrast, after near-total pancreatectomy, 13 of the @entity0 with @entity2 had persistent @entity7 , @entity1 developed in 8, and @entity8 developed in another 7; overall, only 2 @entity0 with @entity2 had normal plasma @entity3 concentrations in the first year after surgery. CONCLUSIONS: Among neonates with @entity6 , about half may have focal islet-cell hyperplasia that can be treated with partial pancreatectomy. These neonates can be identified through pancreatic catheterization and intraoperative histologic studies.

title: Clinical features of 52 neonates with XXXX .

answer: @entity6


abstract: This report describes the case of the youngest Japanese @entity0 to be diagnosed with @entity2 . In September 2005, a 17-year-old female adolescent visited a physician because of @entity3 . @entity1 was discovered, and the @entity0 was referred to our outpatient department. Vaginal examination showed a bleeding @entity1 approximately 1.5 cm in size protruding from the cervical os. The cytological finding of the uterine cervix was positive for @entity1 , and the histological diagnosis by punch biopsy was clear-cell @entity2 . A radical abdominal hysterectomy and pelvic lymphadenectomy were performed on October 30. Macroscopic findings showed a @entity1 , 1.5 cm in diameter, growing from the right side of the uterine cervix. The pathological diagnosis was clear-cell @entity2 (PT1b1NR0M0). The @entity0 was discharged from our hospital without any adjuvant therapy. No signs of recurrence have been detected in the 2-year follow up.

title: Clear-cell XXXX in a 17-year-old adolescent.

answer: @entity2


abstract: OBJECTIVE: To review the literature on the surgical treatment of @entity6 and to present preliminary results from a pilot study of lung volume reduction (LVR) surgery. DESIGN: Case series of consecutive @entity0 referred for LVR surgery. Outcomes were quality of life, pulmonary function and exercise capacity. SETTING: Two university-affiliated hospitals in Ontario. POPULATION STUDIED: @entity0 between the ages of 40 and 75 years with @entity6 who had severe airflow limitation, hyperinflation of the lungs and impaired quality of life. INTERVENTION: @entity4 with multiple wedge resections of the lung using a linear stapling device with @entity3 pericardial buttressing were completed via a median sternotomy. MAIN RESULTS: Of 50 @entity0 referred, 24 underwent LVR surgery. Mean age of the cohort was 63 years. Operative 30-day or in hospital mortality was 8%. Two other @entity0 (8%) died from @entity5 after LVR within the first year. @entity2 included prolonged air leaks (six of 24), tracheobronchitis (five of 24), mechanical ventilation (four of 24) and @entity1 (three of 24). Mean length of stay was 18 days (median 12 days). At one year, there was a sustained decrease in total lung capacity from 133% to 123% predicted. There were improvements in forced expiratory volume in 1 s, from 22% of predicted preoperatively to 32% postoperatively, and in 6 min walk performance, from 345 to 381 m. Improvements were also noted in the quality of life assessments. CONCLUSIONS: Preliminary results suggest that LVR surgery is feasible and may improve the @entity0 's quality of life, pulmonary function and exercise capacity. A randomized clinical trial comparing LVR plus the best medical management with the best medical management alone is currently underway to determine the effectiveness of LVR.

title: Lung volume reduction for XXXX and the Canadian Lung Volume Reduction Surgery (CLVR) Project.

answer: @entity6


abstract: INTRODUCTION: @entity1 are, at the present time, considered among the most important causes of morbidity and mortality after heart surgery. We evaluated their importance and risk factors. @entity0 AND METHODS: We retrospectively reviewed 2, 528 consecutive @entity0 who underwent cardiopulmonary bypass in a single center. In each one, we attended to previous vascular risk factors, such as surgical and postoperative events. We considered four categories of neurologic outcome: (1) persistent @entity2 , (2) stupor or @entity5 , (3) @entity2 , and (4) seizures. We carried out univariant and multivariant statistical analysis, looking for predictors of adverse neurologic events. RESULTS: @entity1 occurred in 76 @entity0 (3%); 36 of them (47%) had persistent @entity2 , 18 (24%) stupor or @entity5 , 18 (24%) @entity2 , and 27 (36%) @entity3 . Twenty-two @entity0 with cerebral adverse outcomes died (29%), the overall mortality among the 2,528 cases being 5%. Predictors of risk were @entity4 and aortic valve surgery, advanced age, female sex, and the use of intra-aortic balloon pump. A longer hospitalization time was noticed among @entity0 with neurological side effects. DISCUSSION: @entity1 are common and serious after heart surgery, as we have noticed with this series, the largest up to now, according to our review of the literature. They increase perioperative mortality and hospitalization time. @entity1 and risk factors in our study are similar to those previously published.

title: XXXX after cardiopulmonary bypass: An update.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Isolated dissecting @entity6 (PICA) carry a high risk of rebleeding with an associated increased mortality rate. Although rare, they present a therapeutic challenge. Surgical treatment carries a significant risk of @entity1 , predominantly lower @entity3 because of the close relationship of the @entity5 with the brain stem and cranial nerves. The purpose of this article is to show that endovascular treatment of dissecting @entity5 of the PICA can be effective and can allow the @entity0 to avoid the complications associated with surgery. METHODS: Six @entity0 (age range, 28-70 years) with dissecting @entity5 of the PICA were treated at our center by endovascular occlusion with Guglielmi detachable coils or glue and followed for up to 30 months. Inclusion of @entity0 in the study was based on careful angiographic assessment of the vascular anatomy and collateral supply of the posterior fossa. When on the basis of the anatomy, potential lack of sufficient collaterals was suggested, a test occlusion was performed to determine the feasibility of an endovascular approach. Four additional cases, which have been described in the literature, were included in the analysis of results. RESULTS: In all @entity0 , the @entity5 was successfully occluded with no apparent procedure-related complications. Follow-up studies showed stable and complete occlusion of the @entity5 in all @entity0 with no long-term @entity2 . CONCLUSIONS: Endovascular treatment by @entity5 and parent @entity4 is a relatively safe and reliable alternative to surgery for isolated dissecting @entity5 of the PICA.

title: Endovascular treatment of isolated dissecting XXXX .

answer: @entity6


abstract: OBJECTIVE: To evaluate clinical results of microscope-assisted minimally invasive decompression for degenerative @entity3 . METHODS: From May 2007 to November 2008, 26 @entity0 with degenerative @entity3 were treated with microscope-assisted minimally invasive decompression. Including 9 males and 17 females, the mean age were 53.7 years (range in 47-75 years). The course of disease was from 2 to 8 years with an average of 3.6 years. Single segment symptom had 20 cases and double segments had 6 cases. The clinical effects were evaluated and improvement rate was calculated according to JOA scoring before and after operation. RESULTS: The operative time in single segment was 60-90 minutes with an average of 75 minutes and in double segments was 80-180 minutes with an average of 95 minutes. The @entity2 in single segment was 50-120 ml with an average of 85 ml and in double segments was 60-150 ml with an average of 100 ml. All the @entity0 were followed up with an average of 8.6 months (range in 6-24 months). The clinical effects were evaluated according to JOA scoring,excellent in 18 cases,good in 7,poor in 1,the rate of excellent and good was 96% and improvement rate was 86%. The mean JOA scoring was respectively 3.92 +/- 0.83 and 12.67 +/- 1.92 before and after operation. There was significantly statistic difference between before and after operation (P < 0.01). CONCLUSION: Microscope-assisted minimally invasive decompression for degenerative @entity3 can obtain satisfactory therapeutic effect,which had advantages of short operative time, less @entity1 , subtle operation, fast restoration, but it is inapplicable for the @entity0 with obviously ossification or calcification of vertebral body, severe vertebral canal adherence.

title: [Microscope-assisted minimally invasive decompression for degenerative XXXX ].

answer: @entity3


abstract: PURPOSE: To assess the clinical efficacy including of EED methods in the treatment of severe @entity1 with @entity2 . MATERIAL AND METHODS: Severe @entity1 in @entity0 (n = 103, aged 18-60 years, male 89%) were randomly subdivided into the 4 comparable groups. The 1st group (n = 30) was standard treated with antibiotics. The 2nd group (n = 27) underwent additionally 3 courses of extracorporeal ultraviolet light-exposure (UVLE). The 3rd group (n = 25) was co-treated with 3 courses of biospecific hemosorption (BSS). The 4th group (n = 21) underwent 2 additional courses of BSS plus 3 courses of UVLE. The effectiveness of these schemes therapy was assessed by clinical and laboratory data. RESULTS: The additional application of EED methods led to faster disappearance of clinical symptoms, focal chest signs and the infiltrate resolution in chest X-ray (CXR) as compared with standard treatment. Mean time of the disappearance of fever and sweating was 2.2; 2.5; 2.0 days and 4.8; 5.0; 4.6 days in the 2nd, 3rd and 4th group respectively after EED courses vs 6.1 and 8.0 days in 1st group (P < 0.05). The baseline elastase activity was elevated by 5 times in the 1st-4th groups vs the control (healthy) group and was decreased by 1.5; 2.1; 4.1; 6.6 times respectively (P < 0.05) after treatment in these groups. The initial trypsin-like activity was increased about 5.5 times in all groups vs control and decreased after therapy by 2.1; 3.8; 6.4; 6.0 times (P < 0.05) in the 1st-4th groups respectively. Small CXR residual changes persisted in 7, 4 and 5 @entity0 from the 2nd, 3rd and 4th groups vs 12 @entity0 in the 1st group. The spirometry data were normalized faster in the @entity0 who underwent EED methods (by the 14th day) vs the 1st group. CONCLUSIONS: Additional using of EED methods in severe @entity1 therapy is more effective (as compared with traditional management with antibiotics only) in term of faster improvement of @entity0 general condition, reduced time of inflammatory infiltrate resolution and hospitalization by 3-4 days. It has been shown that EED methods correct the main pathogenic mechanisms of severe @entity1 . Our results indicated on the EED methods as an attractive supportive therapy for the empiric antibiotics treatment of this disease.

title: The effect of extracorporeal efferent detoxication (EED) methods inclusion in the severe @entity1 ( XXXX ) treatment.

answer: @entity1


abstract: PURPOSE: To assess the clinical efficacy including of EED methods in the treatment of severe @entity1 with @entity2 . MATERIAL AND METHODS: Severe @entity1 in @entity0 (n = 103, aged 18-60 years, male 89%) were randomly subdivided into the 4 comparable groups. The 1st group (n = 30) was standard treated with antibiotics. The 2nd group (n = 27) underwent additionally 3 courses of extracorporeal ultraviolet light-exposure (UVLE). The 3rd group (n = 25) was co-treated with 3 courses of biospecific hemosorption (BSS). The 4th group (n = 21) underwent 2 additional courses of BSS plus 3 courses of UVLE. The effectiveness of these schemes therapy was assessed by clinical and laboratory data. RESULTS: The additional application of EED methods led to faster disappearance of clinical symptoms, focal chest signs and the infiltrate resolution in chest X-ray (CXR) as compared with standard treatment. Mean time of the disappearance of fever and sweating was 2.2; 2.5; 2.0 days and 4.8; 5.0; 4.6 days in the 2nd, 3rd and 4th group respectively after EED courses vs 6.1 and 8.0 days in 1st group (P < 0.05). The baseline elastase activity was elevated by 5 times in the 1st-4th groups vs the control (healthy) group and was decreased by 1.5; 2.1; 4.1; 6.6 times respectively (P < 0.05) after treatment in these groups. The initial trypsin-like activity was increased about 5.5 times in all groups vs control and decreased after therapy by 2.1; 3.8; 6.4; 6.0 times (P < 0.05) in the 1st-4th groups respectively. Small CXR residual changes persisted in 7, 4 and 5 @entity0 from the 2nd, 3rd and 4th groups vs 12 @entity0 in the 1st group. The spirometry data were normalized faster in the @entity0 who underwent EED methods (by the 14th day) vs the 1st group. CONCLUSIONS: Additional using of EED methods in severe @entity1 therapy is more effective (as compared with traditional management with antibiotics only) in term of faster improvement of @entity0 general condition, reduced time of inflammatory infiltrate resolution and hospitalization by 3-4 days. It has been shown that EED methods correct the main pathogenic mechanisms of severe @entity1 . Our results indicated on the EED methods as an attractive supportive therapy for the empiric antibiotics treatment of this disease.

title: The effect of extracorporeal efferent detoxication (EED) methods inclusion in the severe XXXX ( @entity1 ) treatment.

answer: @entity1


abstract: PURPOSE: The aim of the study was to determine the safety of three intensive insulin therapy methods: @entity4 ( @entity4 ), continuous subcutaneous insulin infusion (CSII) and continuous intravenous insulin infusion (IVII) used in poorly controlled type 2 @entity1 @entity0 in hospital condition. The safety of these intensive insulin therapy methods was measured by the assessment of number and duration of symptomatic and symptomfree hypoglycaemic events with use of Continuous @entity2 Monitoring System (CGMS, Medtronic MiniMed). MATERIAL AND METHODS: The study comprised 90 type 2 @entity1 @entity0 treated with conventional insulin therapy based on a twice daily injections with mean @entity2 profile values > 14 mmol/l. The @entity0 were randomized into three groups according to the method of insulin treatment. The first group was treated with @entity4 , the second group with CSII and the third with IVII. The @entity2 monitoring with the use of CGMS lasted 48 hours and was conducted on the second and on the third day of intensive insulin therapy. @entity2 level below 3.5 mmol/l were recognized as @entity3 . Intensive insulin treatment was continued until "near normoglycaemia" ( @entity2 levels 4.5-10.0 mmol/l) was achieved and then conventional insulin therapy was readministrated. RESULTS: Mean number of symptomatic hypoglycaemic events detected with CGMS was two times higher for @entity4 than for IVII (p = 0.04) and for CSII (p = 0.04). Number of symptomfree hypoglycaemic events detected with CGMS was higher for @entity4 than for IVII and CSII, but the differences were insignificant (NS). Mean duration of one symptomfree hypoglycaemic event detected with CGMS was longer in @entity4 than in CSII (p = 0.02) and IVII (p = 0.03). It was not observed significant differences in mean duration of one symptomatic @entity3 between studied groups (NS). CONCLUSIONS: The results of study suggest that CSII and IVII treatment is associated with essentially lower number of symptomatic hypoglycaemic events and shorter mean duration of one symptomfree hypoglycaemic event than @entity4 .

title: Safety of various methods of intensive insulin therapy in hospital condition assessed by hypoglycaemic episodes detected with the use of continuous XXXX monitoring system.

answer: @entity2


abstract: PURPOSE: NT-proBNP and @entity3 concentrations in CHF correlate with NYHA class and LVEE Little research has been conducted to compare the clinical performance of these two natriuretic peptides in heterogeneous CHF population. Purpose: to evaluate and compare the clinical performance of NT-proBNP and @entity3 in heterogeneous group of CHF @entity0 on the basis of these peptides' correlation with NYHA class, LVEF and WMI measured by echocardiography. MATERIAL AND METHODS: Consecutive @entity0 admitted for suspected of CHE Blood samples were drawn for NT-proBNP, @entity3 , @entity2 and echocardiography was performed. RESULTS: 71 @entity0 were included. CHF was diagnosed in 53. Sensitivity of NT-proBNP and @entity3 in diagnosing CHF was 83% and 94% respectively (P = 0.079). Levels of both peptides correlated equally well with NYHA class (R = 0.537, p < 0.001; R = 0.473, P < 0.001), LVEF (R = -0.623, p < 0.001; R = -0.601, P < 0.001) and WMI (R = 0.590, P < 0.001; R = 0.527, P = 0.001). @entity2 correlated with both peptides, age correlated with NT-proBNP. No difference between sexes was found in both peptides' concentrations. In multivariate analysis independent determinants of @entity3 were LVEF, presence of @entity1 and NYHA class. In case of NT-proBNP age and @entity2 also displayed independent influence. CONCLUSIONS: NT-proBNP and @entity3 show good sensitivity in detecting CHE Levels of both peptides correlate equally well with clinical and echocardiographic parameters of CHF, which makes them equally adequate in biochemical staging of CHF's severity regardless of its underlying cause. Levels of natriutretic peptides reflect contractile dysfunction, @entity1 and clinical condition. Age and @entity2 concentration but not @entity0 ' sex should additionally be considered when measuring NT-proBNP.

title: Correlation of B type natriuretic peptides with clinical and echocardiographic parameters in heterogeneous population of XXXX with symptoms suggestive of heart failure.

answer: @entity0


abstract: Due to the large variations in the absorption and bioavailability of conventional @entity3 (CyA), 1:1 (mg:mg) conversion to its microemulsion formulation (Neoral) has been advocated in transplant recipients. However, the renal hazards and biochemical effects of such conversions and not known in cardiac transplant recipients. In this study, 68 cardiac transplant recipients who were receiving conventional CyA, for a period of 61.3 +/- 36.0 (mean +/- @entity7 ( @entity7 )) months, were switched to the microemulsion formulation (Neoral). The biochemical and renal function tests were evaluated at 1, 3, 6, 9 and 12 months pre- and post-conversion of CyA. The results obtained post-conversion were compared with those of the baseline (pre-conversion). Serum @entity6 and @entity4 levels significantly increased post-conversion to the microemulsion formulation. One @entity0 required discontinuation of the microemulsion in an attempt to reverse severe @entity2 . In spite of a significant decrease in the microemulsion dose at 6, 9 and 12 months, there was a significant increase in the whole blood CyA trough levels at 9 and 12 months of conversion. There was no significant change in blood pressure, serum total @entity1 or @entity5 post-conversion. Our results suggest that after 1:1 (mg:mg) conversion of CyA to its microemulsion formulation, there will be a significant rise in serum @entity6 , @entity4 and whole blood trough CyA levels necessitating significant dose reduction. This effect is probably due to the markedly improved absorption and bioavailability of the latter.

title: The impact of (1:1) XXXX conversion to its microemulsion formulation on the kidney function of @entity0 with cardiac allografts.

answer: @entity3


abstract: Due to the large variations in the absorption and bioavailability of conventional @entity3 (CyA), 1:1 (mg:mg) conversion to its microemulsion formulation (Neoral) has been advocated in transplant recipients. However, the renal hazards and biochemical effects of such conversions and not known in cardiac transplant recipients. In this study, 68 cardiac transplant recipients who were receiving conventional CyA, for a period of 61.3 +/- 36.0 (mean +/- @entity7 ( @entity7 )) months, were switched to the microemulsion formulation (Neoral). The biochemical and renal function tests were evaluated at 1, 3, 6, 9 and 12 months pre- and post-conversion of CyA. The results obtained post-conversion were compared with those of the baseline (pre-conversion). Serum @entity6 and @entity4 levels significantly increased post-conversion to the microemulsion formulation. One @entity0 required discontinuation of the microemulsion in an attempt to reverse severe @entity2 . In spite of a significant decrease in the microemulsion dose at 6, 9 and 12 months, there was a significant increase in the whole blood CyA trough levels at 9 and 12 months of conversion. There was no significant change in blood pressure, serum total @entity1 or @entity5 post-conversion. Our results suggest that after 1:1 (mg:mg) conversion of CyA to its microemulsion formulation, there will be a significant rise in serum @entity6 , @entity4 and whole blood trough CyA levels necessitating significant dose reduction. This effect is probably due to the markedly improved absorption and bioavailability of the latter.

title: The impact of (1:1) @entity3 conversion to its microemulsion formulation on the kidney function of XXXX with cardiac allografts.

answer: @entity0


abstract: INTEREST OF WORK: The longitudinal or "sleeve" gastrectomy was recently introduced into the therapeutic arsenal of the bariatric surgeon. It is a restrictive procedure that reduces stomach capacity by 75%. We present here a preliminary experience with four @entity0 . METHODS: Four @entity0 with super super @entity1 (body mass index (BMI)>60 kg/m2) underwent longitudinal or "sleeve" gastrectomy. Their average preoperative weight was 173 kg (range: 147-190 kg) and mean BMI 65 kg/m2 (range: 61-67 kg/m2). RESULTS: The average post-operative follow-up was 6 months (range: 2-12 months). Average @entity2 at 6 months was 40 kg (range: 20-60 kg) and average decrease in BMI at 6 months 16.3 kg/m2 (range: 6-23 kg/m2). We noted a postsurgical complication in only one @entity0 ( @entity3 treated with drainage). PERSPECTIVES: These preliminary results suggest that the sleeve gastrectomy is associated with few perioperative complications and offers rapidly effective treatment for super super morbid @entity1 . Long-term results require further investigation.

title: [Treatment of super super morbid XXXX by sleeve gastrectomy].

answer: @entity1


abstract: Research has demonstrated that short-term psychological interventions improve the quality of life of @entity2 @entity1 . However, there is much less evidence for the efficacy of long-term interventions. We report the psychometric results from a randomized clinical trial (n = 66) assessing the effects of an 8 month, weekly psychological intervention on 30 metastatic @entity0 @entity1 . Subjects were assessed at baseline, 4, 8 and 14 months for mood, quality of life and adjustment to @entity2 . Results demonstrated little psychometric difference between the control (n = 36) and intervention groups over this length of time, in spite of the fact that when the intervention subjects attended a weekend of support and training in coping skills, the usual significant, short-term changes were observed. In the long-term intervention, subjects did experience more anxious preoccupation and less helplessness than the controls but no recorded improvements in mood or quality of life. However, profound clinical changes were observed by the therapists, similar to those noted by Spiegel et al. (1981). We conclude that many of the psychological changes made by subjects in long-term interventions may elude conventional psychometric assessment. Further research, of a rigorous qualitative nature, is required to develop a clearer understanding of the experience of living and eventually dying of @entity2 within the context of a long-term intervention.

title: Psychological response to long-term group therapy: a randomized trial with metastatic XXXX @entity1 .

answer: @entity0


abstract: Research has demonstrated that short-term psychological interventions improve the quality of life of @entity2 @entity1 . However, there is much less evidence for the efficacy of long-term interventions. We report the psychometric results from a randomized clinical trial (n = 66) assessing the effects of an 8 month, weekly psychological intervention on 30 metastatic @entity0 @entity1 . Subjects were assessed at baseline, 4, 8 and 14 months for mood, quality of life and adjustment to @entity2 . Results demonstrated little psychometric difference between the control (n = 36) and intervention groups over this length of time, in spite of the fact that when the intervention subjects attended a weekend of support and training in coping skills, the usual significant, short-term changes were observed. In the long-term intervention, subjects did experience more anxious preoccupation and less helplessness than the controls but no recorded improvements in mood or quality of life. However, profound clinical changes were observed by the therapists, similar to those noted by Spiegel et al. (1981). We conclude that many of the psychological changes made by subjects in long-term interventions may elude conventional psychometric assessment. Further research, of a rigorous qualitative nature, is required to develop a clearer understanding of the experience of living and eventually dying of @entity2 within the context of a long-term intervention.

title: Psychological response to long-term group therapy: a randomized trial with metastatic @entity0 XXXX .

answer: @entity1


abstract: BACKGROUND: None of the existing theories provides a satisfactory explanation of the development of @entity1 . One hypothesis that may lead to further clarification is that the expression of specific proteins of @entity0 endogenous retroviruses (HERVs) might influence the development of @entity2 . Such endogenous retroviral proteins include syncytin, coded by @entity4 , which is associated with the physiological development of the placenta during pregnancy. This study investigated the influence of @entity4 gene expression in @entity1 foci (EM) quantitatively at the RNA level. MATERIALS AND METHODS: Specific RNA expression of syncytin ( @entity4 ) was investigated in various endometrial tissues from 42 @entity0 (with normal endometrium, postmenopausal endometrium, EM, and @entity3 ). RNA was isolated from the tissue samples and transcribed into DNA using reverse transcriptase polymerase chain reaction. The resulting DNA fragments were analyzed using agarose gel electrophoresis and assessed quantitatively. RESULTS: Normalized syncytin expression was low in EM. In Histologically normal endometrium from @entity1 @entity0 , the expression of normalized syncytin was seven times higher in comparison with the histologically normal endometrium in the control group. CONCLUSIONS: @entity4 syncytin expression apparently does not play a role in EM. However, it may possibly influence the development of @entity1 because of increased expression in normal endometrium in @entity1 @entity0 .

title: Expression of the @entity0 endogenous retroviruse-W envelope gene syncytin in XXXX .

answer: @entity2


abstract: BACKGROUND: None of the existing theories provides a satisfactory explanation of the development of @entity1 . One hypothesis that may lead to further clarification is that the expression of specific proteins of @entity0 endogenous retroviruses (HERVs) might influence the development of @entity2 . Such endogenous retroviral proteins include syncytin, coded by @entity4 , which is associated with the physiological development of the placenta during pregnancy. This study investigated the influence of @entity4 gene expression in @entity1 foci (EM) quantitatively at the RNA level. MATERIALS AND METHODS: Specific RNA expression of syncytin ( @entity4 ) was investigated in various endometrial tissues from 42 @entity0 (with normal endometrium, postmenopausal endometrium, EM, and @entity3 ). RNA was isolated from the tissue samples and transcribed into DNA using reverse transcriptase polymerase chain reaction. The resulting DNA fragments were analyzed using agarose gel electrophoresis and assessed quantitatively. RESULTS: Normalized syncytin expression was low in EM. In Histologically normal endometrium from @entity1 @entity0 , the expression of normalized syncytin was seven times higher in comparison with the histologically normal endometrium in the control group. CONCLUSIONS: @entity4 syncytin expression apparently does not play a role in EM. However, it may possibly influence the development of @entity1 because of increased expression in normal endometrium in @entity1 @entity0 .

title: Expression of the XXXX endogenous retroviruse-W envelope gene syncytin in @entity2 .

answer: @entity0


abstract: PURPOSE: To determine the needs, barriers and facilitators of function in individuals with @entity1 after discharge from hospital. To examine the results stratified by the @entity0 's acute score (<41, 41-80, >80) on the functional independence measure (FIM). METHOD: This was a cohort study of 209 @entity0 who had been admitted to hospital because of @entity1 . @entity0 were interviewed following hospital discharge using a semi-structured interview and asked to complete and return a quantitative closed-ended survey. RESULTS: For most domains, frequencies of needs varied across the FIM groups. Combining all FIM groups, the interview showed needs related to: @entity2 (35%), time for recovery (33%), education (28%), medical advice (25%), therapies and services (21%), social needs (19%) and emotional needs (18%). From the interview, the most frequent barriers were @entity2 (55%) and emotional concerns (40%). Common facilitators were family support (54%), therapies and medical care (40%) and personal attitudes (22%). Additional needs from the survey concerned: IADL, mobility, ADL, recreation, finances, communication and employment. Additional barriers from the survey were: attitudes, social participation, environments and limited services. CONCLUSIONS: There is a large and varied number of needs and barriers following discharge from hospital that have planning and advocacy implications for rehabilitation teams.

title: Needs assessment of individuals with XXXX after discharge from hospital stratified by acute Functional Independence Measure score.

answer: @entity1


abstract: OBJECTIVE: To study the effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity. DESIGN: Prospective, randomized, controlled study. SETTING: Academic hospital. @entity0 (S): Healthy postmenopausal @entity0 with an intact uterus. INTERVENTION(S): For the first 12 months, the hormone replacement therapy group (n = 14) received oral E2, 1 mg daily, sequentially combined with 5 or 10 mg of @entity4 . Thereafter, they received oral E2, 2 mg daily, sequentially combined with 10 mg of @entity4 . The control group (n = 13) received no treatment. Data were collected at baseline and at 3, 12, and 15 months. MAIN OUTCOME MEASURE(S): Parameters of endothelial function and inflammatory activity. RESULT(S): During 12 months of follow-up, we observed decreases of 15% in plasma levels of endothelin-l, of 21% in soluble thrombomodulin, of 14% in @entity2 factor, and of 12% in clottable fibrinogen in the hormone replacement therapy group compared with the control group. There was a 5% decrease in soluble @entity3 tevels. All significant changes were observed by 3 months and sustained after 15 months. Brachial artery flow-mediated vasodilatation and @entity1 levels did not change significantly. CONCLUSION(S): Long-term combined hormone replacement therapy with E2 and @entity4 in healthy @entity0 was associated with sustained improvement in some aspects of endothelial function and in clottable fibrinogen levels.

title: Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal XXXX .

answer: @entity0


abstract: BACKGROUND: @entity2 (DA) storage and release are reduced in @entity3 ( @entity3 ) in a wide range of species, from chicks to primates. @entity3 can be prevented by treatment with DA agonists such as @entity7 , and paradoxically by the @entity2 neurotoxin @entity6 . In this study, we increased the DA levels by direct intravitreal DA injections to learn if @entity3 can be suppressed in a @entity0 model. METHODS: Seven-day-old @entity0 were deprived of pattern vision by the suturing the right eyelids after natural eye opening. In the first group ( @entity4 , n=20), the right eye received @entity4 ( @entity4 ) alone. In the second group (DA- @entity4 , n=16), the deprived eye of 7-day-old @entity0 received four intravitreal injections of 20 microg @entity2 every 5 days. In the third group (saline- @entity4 , n=16), the deprived eye received saline injections with the same schedule. The contralateral eye remained untreated as a control. At the end of the 8-week deprivation period, the effects of DA on @entity5 , corneal curvature and ocular dimensions were assessed by streak retinoscopy, keratometry and A-scan ultrasonography, respectively. RESULTS: Eight weeks of @entity3 induced a myopic shift of -2.70+/-0.87 D (n=20) in treated eyes compared with @entity1 . The major structural correlate of the @entity3 appeared to be elongation of the vitreous chamber (0.7+/-0.3 mm, n=20) and axial elongation (0.9+/-0.3 mm, n=20), respectively. Repeated intravitreal injections of DA fully prevented the myopic shift (-0.06+/-0.37 D), elongation of the vitreous chamber (0.1+/-0.3 mm, n=16) and axial elongation (0.3+/-0.2 mm, n=16) due to lid suture, whereas saline injections had slight effect. CONCLUSIONS: @entity4 by suturing eyelids is an effective technique to induce a significant myopic shift, vitreous chamber and axial elongation in @entity0 as a model of @entity3 development. These changes associated with @entity4 were retarded by intravitreal injections of DA.

title: Effects of direct intravitreal XXXX injections on the development of lid-suture induced @entity3 in @entity0 .

answer: @entity2