abstract: Historical notes on Walter Linsenmaier, his entomological career and his Chrysididae collection are given. The purpose of this article is to supply the main results obtained during the @entity1 digitalization project and the subsequent reorganization of the Chrysididae collection housed in the Natur-Museum Luzern (Switzerland); we also provide the complete list of the 720 taxa described by the Swiss author (species-group and genus-group names). Observations on the type material is given. A new synonymy (valid name is first) is proposed for: C. consanguinea Mocs  ry, 1889 = C. consanguinea iberica Linsenmaier, 1959, @entity0 . nov.; C. pyrophana Dahlbom, 1854 = C. pyrophana var. orionea Linsenmaier, 1951, @entity0 . nov.; Hedychridium elegantulum du Buysson, 1887 = H. hybridum Linsenmaier, 1959, @entity0 . nov.; H. perpunctatum Balthasar, 1953 = H. insequosum Linsenmaier, 1959, @entity0 . nov.; Euchroeus (Pseudospinolia) incrassatus (Spinola, 1838) = E. (P.) humboldti jerichoensis Linsenmaier, 1959, @entity0 . nov. A new replacement name Chrysis vulcanica Rosa, nom. nov. is proposed for Chrysis brevicollis Linsenmaier, 1987, nom praeocc., nec Mocs  ry, 1899. The lectotype of Chrysis auriceps Linsenmaier, 1959 is designated.

title: The Linsenmaier Chrysididae collection housed in the Natur-Museum  Luzern (Switzerland) and the main results of the related  XXXX Hymenoptera Project (Insecta).

answer: @entity1


abstract: Pulmonary manifestations associated with @entity7 are rich in variety. We report the first case of food-induced @entity3 mimicking @entity1 ( @entity1 ). A 77-year-old @entity0 with respiratory symptoms was referred to our hospital. We performed a surgical lung biopsy, which showed the features of @entity3 . Her clinical history resembled those observed in @entity1 . However, avoidance of exposure to the causative antigens did not improve her symptoms. Moreover, the @entity0 had some features inconsistent with @entity1 , such as elevated serum @entity8 levels, blood @entity6 , intrathoracic lymphadenopathies and @entity5 . Therefore, we pursued another extrinsic non-inhaled antigen as the cause of @entity2 . We noted that she had been eating homemade @entity4 bran pickles, and @entity2 were induced by an ingestion challenge test. We suggest that @entity3 may be a rare subtype of the pulmonary manifestations associated with @entity7 .

title: Granulomatous @entity3 induced by the intake of @entity4 bran pickles: a rare subtype of pulmonary manifestation associated with XXXX .

answer: @entity7


abstract: Pulmonary manifestations associated with @entity7 are rich in variety. We report the first case of food-induced @entity3 mimicking @entity1 ( @entity1 ). A 77-year-old @entity0 with respiratory symptoms was referred to our hospital. We performed a surgical lung biopsy, which showed the features of @entity3 . Her clinical history resembled those observed in @entity1 . However, avoidance of exposure to the causative antigens did not improve her symptoms. Moreover, the @entity0 had some features inconsistent with @entity1 , such as elevated serum @entity8 levels, blood @entity6 , intrathoracic lymphadenopathies and @entity5 . Therefore, we pursued another extrinsic non-inhaled antigen as the cause of @entity2 . We noted that she had been eating homemade @entity4 bran pickles, and @entity2 were induced by an ingestion challenge test. We suggest that @entity3 may be a rare subtype of the pulmonary manifestations associated with @entity7 .

title: Granulomatous @entity3 induced by the intake of XXXX bran pickles: a rare subtype of pulmonary manifestation associated with @entity7 .

answer: @entity4


abstract: Pulmonary manifestations associated with @entity7 are rich in variety. We report the first case of food-induced @entity3 mimicking @entity1 ( @entity1 ). A 77-year-old @entity0 with respiratory symptoms was referred to our hospital. We performed a surgical lung biopsy, which showed the features of @entity3 . Her clinical history resembled those observed in @entity1 . However, avoidance of exposure to the causative antigens did not improve her symptoms. Moreover, the @entity0 had some features inconsistent with @entity1 , such as elevated serum @entity8 levels, blood @entity6 , intrathoracic lymphadenopathies and @entity5 . Therefore, we pursued another extrinsic non-inhaled antigen as the cause of @entity2 . We noted that she had been eating homemade @entity4 bran pickles, and @entity2 were induced by an ingestion challenge test. We suggest that @entity3 may be a rare subtype of the pulmonary manifestations associated with @entity7 .

title: Granulomatous XXXX induced by the intake of @entity4 bran pickles: a rare subtype of pulmonary manifestation associated with @entity7 .

answer: @entity3


abstract: BACKGROUND AND AIM: Lymph node @entity1 is a major prognostic factor for perihilar @entity2 (PHC). However, prognostic significance of extent of node dissection, lymph node ratio (LNR), and number and location of positive nodes remain unclear. We aimed to evaluate whether node status, LNR, or number or location of positive nodes are independent factors for staging in PHC and to determine the minimum requirements for node examination. METHODS: The Surveillance, Epidemiology, and End Results database was used to identify 1116 resected PHCs from 1998 to 2008. The correlation between nodal status and survival was analyzed retrospectively. RESULTS: Lymph node @entity1 occurred in 43.4% @entity0 and was an independent predictor for overall survival and cancer-specific survival. No survival benefit was observed for an increasing number of node retrieval in node-positive @entity0 . However, in node-negative @entity0 , >= 13 node dissection was of more survival benefit than 3    <=   total lymph node count (TLNC)    <=   12 and TLNC   <   3 (5-year overall survival: 52.8% vs 39.7% vs 26.3%, P   =   0.001; 5-year cancer-specific survival: 60.6% vs 46.3% vs 30.0%, P   =   0.001). No difference in survival between @entity0 with regional and distant node involvement was found. Survival for @entity0 with greater than three positive nodes was significantly worse than that for those with three or less (relative ratio: 1.466, P   =   0.001). And @entity0 with LNR   >   0.27 also had unfavorable prognosis (relative ratio: 1.376, P   =   0.001). CONCLUSIONS: We determined that to adequately assess nodal status of this life-threatening disease, 13 or more nodes retrieval should be considered. Number of positive nodes and LNR rather than location of metastatic nodes may be defined as parameters for staging of PHC.

title: Patterns and prognostic value of lymph node dissection for resected perihilar XXXX .

answer: @entity2


abstract: INTRODUCTION AND OBJECTIVES: Selective neuronal loss (SNL) in the reperfused penumbra may impact clinical recovery and is thus important to investigate. Brief proximal @entity7 ( @entity7 ) results in predominantly striatal SNL, yet cortical damage is more relevant given its behavioral implications and that thrombolytic therapy mainly rescues the cortex. Distal temporary @entity7 (tMCAo) does target the cortex, but the optimal occlusion duration that results in isolated SNL has not been determined. In the present study, we assessed different distal tMCAo durations looking for consistently pure SNL. METHODS: Microclip distal tMCAo (md-tMCAo) was performed in ~6-month old male spontaneously @entity3 @entity0 (SHRs). We previously reported that 45   min md-tMCAo in SHRs results in pan- @entity1 in the majority of subjects. Accordingly, three @entity7 were investigated here in decremental succession, namely 30, 22, and 15   min (n   =   3, 3, and 7 subjects, respectively). Recanalization was confirmed by MR angiography just prior to brain collection at 28   days and T2-weighted MRI was obtained for characterization of @entity8 . @entity6 , OX42, and @entity2 immunohistochemistry appraised changes in neurons, microglia, and astrocytes, respectively. @entity8 were categorized into three main types: (1) pan- @entity1 ; (2) partial @entity5 ; and (3) SNL. RESULTS: Pan- @entity1 or partial @entity5 was present in all 30   min and 22   min subjects, but not in the 15   min group (p   <   0.001), in which isolated cortical SNL was consistently present. MRI revealed @entity4 in all @entity0 with pan- @entity1 or partial @entity5 , but no change in any 15   min subject. CONCLUSION: We found that 15   min distal @entity7 consistently resulted in pure cortical SNL, whereas durations equal or longer than 22   min consistently resulted in @entity5 . This model may be of use to study the pathophysiology of cortical SNL and its prevention by appropriate interventions.

title: What is the Optimal Duration of Middle-Cerebral Artery Occlusion Consistently Resulting in Isolated Cortical Selective Neuronal Loss in the Spontaneously XXXX @entity0 ?

answer: @entity3


abstract: INTRODUCTION AND OBJECTIVES: Selective neuronal loss (SNL) in the reperfused penumbra may impact clinical recovery and is thus important to investigate. Brief proximal @entity7 ( @entity7 ) results in predominantly striatal SNL, yet cortical damage is more relevant given its behavioral implications and that thrombolytic therapy mainly rescues the cortex. Distal temporary @entity7 (tMCAo) does target the cortex, but the optimal occlusion duration that results in isolated SNL has not been determined. In the present study, we assessed different distal tMCAo durations looking for consistently pure SNL. METHODS: Microclip distal tMCAo (md-tMCAo) was performed in ~6-month old male spontaneously @entity3 @entity0 (SHRs). We previously reported that 45   min md-tMCAo in SHRs results in pan- @entity1 in the majority of subjects. Accordingly, three @entity7 were investigated here in decremental succession, namely 30, 22, and 15   min (n   =   3, 3, and 7 subjects, respectively). Recanalization was confirmed by MR angiography just prior to brain collection at 28   days and T2-weighted MRI was obtained for characterization of @entity8 . @entity6 , OX42, and @entity2 immunohistochemistry appraised changes in neurons, microglia, and astrocytes, respectively. @entity8 were categorized into three main types: (1) pan- @entity1 ; (2) partial @entity5 ; and (3) SNL. RESULTS: Pan- @entity1 or partial @entity5 was present in all 30   min and 22   min subjects, but not in the 15   min group (p   <   0.001), in which isolated cortical SNL was consistently present. MRI revealed @entity4 in all @entity0 with pan- @entity1 or partial @entity5 , but no change in any 15   min subject. CONCLUSION: We found that 15   min distal @entity7 consistently resulted in pure cortical SNL, whereas durations equal or longer than 22   min consistently resulted in @entity5 . This model may be of use to study the pathophysiology of cortical SNL and its prevention by appropriate interventions.

title: What is the Optimal Duration of Middle-Cerebral Artery Occlusion Consistently Resulting in Isolated Cortical Selective Neuronal Loss in the Spontaneously @entity3 XXXX ?

answer: @entity0


abstract: BACKGROUND: Circulating cell-free DNA (cfDNA) in plasma has shown potential as biomarker in various @entity1 and could become an importance source for @entity1 mutation detection. The objectives of our study were to establish a normal range of cfDNA in a cohort of healthy individuals and to compare this with four cohorts of metastatic @entity2 (mCRC) @entity0 . We also investigated the prognostic value of cfDNA and analysed the @entity1 -specific @entity4 mutations in the plasma. METHODS: The study was a prospective biomarker evaluation in four consecutive Phase II trials, including 229 @entity0 with chemotherapy refractory mCRC and 100 healthy individuals. Plasma was obtained from an @entity5 blood-sample, and the total number of DNA alleles and @entity4 mutated alleles were assessed using an in-house ARMS-qPCR as previously described. RESULTS: Median cfDNA levels were higher in mCRC compared to controls (p < 0.0001). ROC analysis revealed an AUC of 0.9486 (p<0.00001). Data showed @entity3 with increasing levels of baseline cfDNA both when categorising @entity0 by quartiles of cfDNA and into low or high cfDNA groups based on the upper normal range of the control group (Median OS 10.2 (8.3-11.7) and 5.2 (4.6-5.9) months, respectively, HR 1.78, p = 0.0006). Multivariate analysis confirmed an independent prognostic value of cfDNA (HR 1.5 (95% CI 1.3-1.7) for each increase in the cfDNA quartile). The overall concordance of @entity4 mutations in plasma and tissue was high (85%). CONCLUSIONS: These data confirm the prognostic value of cfDNA measurement in plasma and utility for mutation detection with the method presented.

title: Circulating free DNA as biomarker and source for mutation detection in metastatic XXXX .

answer: @entity2


abstract: BACKGROUND: Preventing @entity1 is an international health priority. In Australia, young @entity0 who live in rural communities are at high risk of unhealthy @entity3 . Interventions which engage young @entity0 and support sustainable behaviour change are needed and comprehensive evaluation of such interventions generates knowledge for population scale-up. This qualitative sub-study aims to identify enablers and barriers to behaviour change initiation and continuation within a community @entity3 prevention program. METHODS: In-depth semi-structured interviews were conducted with program @entity0 6 months after baseline. All interviews were audio-taped and transcribed verbatim. Transcripts were analysed independently by two investigators via thematic analysis. @entity0 : A total of 28 @entity0 with a mean age of 39.9  6.2years and a BMI of 28.6  5.2kg/m2 were purposively recruited from the larger cohort (n = 649) that participated in the prevention trial. RESULTS: Four behaviour change groups emerged were identified from @entity0 interviews: (i) no change, (ii) relapse, (iii) intermittent and (iv) continued change. Factors influencing behaviour change initiation and continuation included realistic program expectations and the @entity0 's ability to apply the core program elements including: setting small, achievable behaviour change goals, problem solving and using self-management techniques. Personal knowledge, skills, motivation, self-efficacy, accountability and perceived social and environmental barriers also affected behaviour change. Satisfaction with personal program progress and the perceived amount of program supports required to achieve ongoing behaviour change varied amongst @entity0 . @entity0 who relapsed expressed a desire for more intensive and regular support from health professionals, identified more barriers unrelated to the program, anticipated significant @entity2 and had lower satisfaction with their progress. CONCLUSION: Initiating and continuing behaviour change is a complex process. Our findings elucidate that initiation and continuation of behaviour change in @entity0 undertaking a @entity3 prevention program may be facilitated by accurate and realistic understanding of program expectation, the ability to apply the core program messages, higher internal motivation, self-efficacy and minimal social and environmental barriers. TRIAL REGISTRATION: Australia _ New Zealand Clinical Trial Registry ACTRN12612000115831 www.anzctr.org.au.

title: Initiating and continuing behaviour change within a XXXX prevention trial: a qualitative investigation.

answer: @entity3


abstract: Background   @entity4 ( @entity4 ), @entity2 ( @entity2 ), and @entity1 ( @entity1 ) are commonly found after coronary artery surgery. These adverse events may also be interwoven in the postoperative period. In this prospective study, we investigated whether posterior pericardiotomy (PP) with intrapericardial tube positioned along the right atrium (pericardial space intervention) is effective in the prevention of these adverse events. Methods   The @entity0 were randomly distributed to the study and control groups. The study group consisted of @entity0 with pericardial space intervention, whereas the control group consisted of @entity0 without pericardial space interventions. In all @entity0 , a straight tube was placed in the anterior mediastinum and an angled tube was placed into the left hemithorax. Results   A total of 210 @entity0 were studied: 107 in the control group and 103 in the study group. Statistically significant results were obtained in the amount of @entity4 , @entity3 , @entity2 (p   =   0.019), and @entity1 during the postoperative period, in favor of the study group. Length of hospital stay was significantly shorter in the study group (6.11        2.31, p   =   0.009). Conclusion   The PP with intrapericardial tube approach is safe, easy, and effective in the prevention of @entity4 , @entity3 , and @entity2 . The use of this approach may reduce the risk of developing @entity1 during the postoperative period. Besides, this technique also reduces the length of hospital stay.

title: The Preventive Effects of Posterior Pericardiotomy with Intrapericardial Tube on the Development of @entity4 , XXXX , and @entity1 after Coronary Artery Surgery: A Prospective, Randomized, Controlled Trial.

answer: @entity2


abstract: Background   @entity4 ( @entity4 ), @entity2 ( @entity2 ), and @entity1 ( @entity1 ) are commonly found after coronary artery surgery. These adverse events may also be interwoven in the postoperative period. In this prospective study, we investigated whether posterior pericardiotomy (PP) with intrapericardial tube positioned along the right atrium (pericardial space intervention) is effective in the prevention of these adverse events. Methods   The @entity0 were randomly distributed to the study and control groups. The study group consisted of @entity0 with pericardial space intervention, whereas the control group consisted of @entity0 without pericardial space interventions. In all @entity0 , a straight tube was placed in the anterior mediastinum and an angled tube was placed into the left hemithorax. Results   A total of 210 @entity0 were studied: 107 in the control group and 103 in the study group. Statistically significant results were obtained in the amount of @entity4 , @entity3 , @entity2 (p   =   0.019), and @entity1 during the postoperative period, in favor of the study group. Length of hospital stay was significantly shorter in the study group (6.11        2.31, p   =   0.009). Conclusion   The PP with intrapericardial tube approach is safe, easy, and effective in the prevention of @entity4 , @entity3 , and @entity2 . The use of this approach may reduce the risk of developing @entity1 during the postoperative period. Besides, this technique also reduces the length of hospital stay.

title: The Preventive Effects of Posterior Pericardiotomy with Intrapericardial Tube on the Development of XXXX , @entity2 , and @entity1 after Coronary Artery Surgery: A Prospective, Randomized, Controlled Trial.

answer: @entity4


abstract: Background   @entity4 ( @entity4 ), @entity2 ( @entity2 ), and @entity1 ( @entity1 ) are commonly found after coronary artery surgery. These adverse events may also be interwoven in the postoperative period. In this prospective study, we investigated whether posterior pericardiotomy (PP) with intrapericardial tube positioned along the right atrium (pericardial space intervention) is effective in the prevention of these adverse events. Methods   The @entity0 were randomly distributed to the study and control groups. The study group consisted of @entity0 with pericardial space intervention, whereas the control group consisted of @entity0 without pericardial space interventions. In all @entity0 , a straight tube was placed in the anterior mediastinum and an angled tube was placed into the left hemithorax. Results   A total of 210 @entity0 were studied: 107 in the control group and 103 in the study group. Statistically significant results were obtained in the amount of @entity4 , @entity3 , @entity2 (p   =   0.019), and @entity1 during the postoperative period, in favor of the study group. Length of hospital stay was significantly shorter in the study group (6.11        2.31, p   =   0.009). Conclusion   The PP with intrapericardial tube approach is safe, easy, and effective in the prevention of @entity4 , @entity3 , and @entity2 . The use of this approach may reduce the risk of developing @entity1 during the postoperative period. Besides, this technique also reduces the length of hospital stay.

title: The Preventive Effects of Posterior Pericardiotomy with Intrapericardial Tube on the Development of @entity4 , @entity2 , and XXXX after Coronary Artery Surgery: A Prospective, Randomized, Controlled Trial.

answer: @entity1


abstract: BACKGROUND: @entity5 are uncommon benign @entity3 usually present in @entity0 , and are rare in adults. Currently, complete resection is still the standard care. Two cases are presented of a cervical @entity4 in an adult. The diagnosis and surgical approach is also discussed. CLINICAL CASE: Case 1. The first case is a 23 year old male with chief complaint of a @entity1 in the posterior triangle of the neck, which showed a substantial increase in size in the last 9 months. No associated signs or symptoms, or any @entity2 history was reported. CT scan of the neck showed images suggestive of a posterior cervical @entity4 . Exploratory cervical surgery was performed, with complete resection of a @entity1 located in the posterior triangle of the neck. Surgery was performed without complications and postoperative care was unremarkable. Case 2. The second case is a 28 @entity0 with a @entity1 in submandibular space. She had history of a previous incomplete operation in another institution 2 years ago, with recurrence of the @entity1 . A second surgery was performed with complete resection without complications, and with a good outcome. CONCLUSIONS: @entity5 is a very rare benign disease, surgical treatment is preferred, but sclerotherapy can be used as alternative treatment.

title: [ XXXX in the adult. A report of 2 cases].

answer: @entity5


abstract: For @entity0 with recurrent and/or metastatic @entity6 of the @entity2 (R/M SCCHN), chemotherapy can prolong life and alleviate symptoms. However, expected gains may be small, not necessarily outweighing considerable @entity3 and high costs. Treatment choice is to a large extent dependent on preferences of doctors and @entity0 and data on these choices are scarce. The purpose of this study is to obtain real-world information on palliative systemic treatment and costs of R/M SCCHN in the Netherlands. In six Dutch @entity2 treatment centers, data were collected on @entity0 and @entity1 characteristics, treatment patterns, disease progression, survival, adverse events, and resource use for R/M SCCHN, between 2006 and 2013. 125 (14 %) out of 893 R/M SCCHN @entity0 received palliative, non-trial first-line systemic treatment, mainly @entity5 + @entity7 + cetuximab (32 %), other @entity5 -based combination therapy (13 %), @entity8 monotherapy (27 %) and @entity4 monotherapy (14 %). Median progression-free survival and overall survival were 3.4 and 6.0 months, respectively. 34 (27 %) @entity0 experienced severe adverse events. Mean total hospital costs ranged from     10,075 (       9,891) ( @entity8 monotherapy) to     39,459 (       21,149) ( @entity5 + @entity7 + cetuximab). Primary cost drivers were hospital stays and anticancer drug treatments. Major health care utilization and costs are involved in systemically treating R/M SCCHN @entity0 with a limited survival.

title: Treatments and costs for recurrent and/or metastatic XXXX of the @entity2 in the Netherlands.

answer: @entity6


abstract: For @entity0 with recurrent and/or metastatic @entity6 of the @entity2 (R/M SCCHN), chemotherapy can prolong life and alleviate symptoms. However, expected gains may be small, not necessarily outweighing considerable @entity3 and high costs. Treatment choice is to a large extent dependent on preferences of doctors and @entity0 and data on these choices are scarce. The purpose of this study is to obtain real-world information on palliative systemic treatment and costs of R/M SCCHN in the Netherlands. In six Dutch @entity2 treatment centers, data were collected on @entity0 and @entity1 characteristics, treatment patterns, disease progression, survival, adverse events, and resource use for R/M SCCHN, between 2006 and 2013. 125 (14 %) out of 893 R/M SCCHN @entity0 received palliative, non-trial first-line systemic treatment, mainly @entity5 + @entity7 + cetuximab (32 %), other @entity5 -based combination therapy (13 %), @entity8 monotherapy (27 %) and @entity4 monotherapy (14 %). Median progression-free survival and overall survival were 3.4 and 6.0 months, respectively. 34 (27 %) @entity0 experienced severe adverse events. Mean total hospital costs ranged from     10,075 (       9,891) ( @entity8 monotherapy) to     39,459 (       21,149) ( @entity5 + @entity7 + cetuximab). Primary cost drivers were hospital stays and anticancer drug treatments. Major health care utilization and costs are involved in systemically treating R/M SCCHN @entity0 with a limited survival.

title: Treatments and costs for recurrent and/or metastatic @entity6 of the XXXX in the Netherlands.

answer: @entity2


abstract: PURPOSE: Repeat sentinel node biopsy (SNB) is an alternative to @entity2 ( @entity2 ) for axillary staging in recurrent @entity0 . This study was conducted to determine factors associated with technical success of repeat SNB. METHODS: A total of 536 @entity1 with locally recurrent nonmetastatic @entity0 underwent lymphatic mapping (LM) and repeat SNB in 29 Dutch hospitals. RESULTS: A total of 179 @entity1 previously underwent breast-conserving surgery (BCS) with SNB, 262 @entity1 BCS with @entity2 and 61 @entity1 mastectomy, 35 with SNB and 26 with @entity2 . Another 34 @entity1 underwent breast surgery without axillary interventions. A repeat sentinel node (SN) was identified in 333 @entity1 (62.1 %) and was successfully removed in 235 (53.5 %). The overall repeat SN identification rate was 62.1 %, varying from 35 to 100 % in the participating hospitals. Previous radiotherapy of the breast [odds ratio (OR) 0.16; 95 % confidence interval (CI) 0.03-0.84], subareolar tracer injection (OR 0.34; 95 % CI 0.16-0.73), and a 2-day LM protocol (OR 0.57; 95 % CI 0.33-0.97) after previous BCS were independently associated with failure of SN identification. Injection of a larger amount of tracer (>180 MBq) led to a higher identification rate (OR 4.40; 95 % CI 1.45-13.32). CONCLUSIONS: Repeat SNB is a technically feasible procedure for axillary staging in recurrent @entity0 @entity1 . Previous radiotherapy appears to be associated with failure of SN identification. Injection with a larger amount of tracer (>180 MBq) leads to a higher identification rate; subareolar injection and a 2-day LM protocol after previous BCS appear to be less adequate.

title: Improving the Success Rate of Repeat Sentinel Node Biopsy in Recurrent XXXX .

answer: @entity0


abstract: BACKGROUND: Free-flap reconstruction via a retroauricular approach (RRA) after robot-assisted neck dissection (RAND) could have cosmetic benefits. This study aimed to compare the surgical outcomes of free-flap reconstruction via a RRA and via a transcervical approach in @entity1 . METHODS: For this matched case-control study, 50 @entity0 with @entity1 requiring free-flap reconstruction were divided into two groups: those reconstructed via a RRA group and those reconstructed via a transcervical approach ( @entity2 group). The total operation time for free-flap reconstruction, the flap survival rate, the length of the hospital stay, the complications, and the scar satisfaction scores were compared between the two groups. RESULTS: The RRA group comprised 25 @entity0 , and the @entity2 group had 25 @entity0 . The mean operation time for reconstruction was 288    77 min in the RRA group and 250    98 min in the @entity2 group (p = 0.132). Flap failure occurred for two @entity0 in the RRA group (8 %) and for one @entity0 in the @entity2 group (4 %) (p = 1.000). The mean hospital stay was 21    18 days in the RRA group and 23    14 days in the @entity2 group (p = 0.669). The complications were comparable between the two groups. However, the overall scar satisfaction was significantly higher in the RRA group (p = 0.000). CONCLUSIONS: For @entity0 with @entity1 , RRA has better cosmetic outcomes than @entity2 . The RRA approach could be used for select @entity0 who undergo RAND and prefer to avoid a visible anterior neck scar.

title: A Study Comparing Free-Flap Reconstruction via the Retroauricular Approach and the Traditional Transcervical Approach for XXXX : A Matched Case-Control Study.

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity3 ) to inhaled @entity4 is associated with indirect markers of mast cell activation and @entity1 . It is unknown how @entity3 to @entity4 relates to mast cell phenotype, mast cell function and measures of @entity1 in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell-associated genes and number of eosinophils in airway tissue of subjects with @entity2 and healthy controls in relation to @entity3 to @entity4 . METHODS: @entity3 to inhaled @entity4 was measured in 23 non-smoking, corticosteroid-free asthmatic individuals and 10 healthy controls. Mast cells and eosinophils were identified in mucosal biopsies from all @entity0 . Mast cells were divided into phenotypes based on the presence of chymase. mRNA expression of mast cell-associated genes was measured by real-time PCR. RESULTS: The proportion of submucosal MCTC was higher in asthmatic individuals with @entity3 to @entity4 compared with asthmatic individuals without @entity3 (median: 40.3% vs. 18.7%, P  =  0.03). Increased submucosal MCTC numbers were associated with increased levels of mRNA for @entity5 ( @entity5 ) and @entity6 in asthmatics. Reactivity to @entity4 correlated significantly with eosinophils in submucosa (r(s): 0.56, P  =  0.01). CONCLUSION: @entity3 to inhaled @entity4 is associated with an altered submucosal mast cell profile in asthmatic individuals. This mast cell profile is associated with increased levels of @entity5 and @entity6 . The degree of @entity3 to @entity4 is correlated with the degree of @entity1 in the airway submucosa.

title: Airway responsiveness to @entity4 in XXXX is associated with chymase-positive mast cells and @entity1 .

answer: @entity2


abstract: BACKGROUND: @entity3 ( @entity3 ) to inhaled @entity4 is associated with indirect markers of mast cell activation and @entity1 . It is unknown how @entity3 to @entity4 relates to mast cell phenotype, mast cell function and measures of @entity1 in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell-associated genes and number of eosinophils in airway tissue of subjects with @entity2 and healthy controls in relation to @entity3 to @entity4 . METHODS: @entity3 to inhaled @entity4 was measured in 23 non-smoking, corticosteroid-free asthmatic individuals and 10 healthy controls. Mast cells and eosinophils were identified in mucosal biopsies from all @entity0 . Mast cells were divided into phenotypes based on the presence of chymase. mRNA expression of mast cell-associated genes was measured by real-time PCR. RESULTS: The proportion of submucosal MCTC was higher in asthmatic individuals with @entity3 to @entity4 compared with asthmatic individuals without @entity3 (median: 40.3% vs. 18.7%, P  =  0.03). Increased submucosal MCTC numbers were associated with increased levels of mRNA for @entity5 ( @entity5 ) and @entity6 in asthmatics. Reactivity to @entity4 correlated significantly with eosinophils in submucosa (r(s): 0.56, P  =  0.01). CONCLUSION: @entity3 to inhaled @entity4 is associated with an altered submucosal mast cell profile in asthmatic individuals. This mast cell profile is associated with increased levels of @entity5 and @entity6 . The degree of @entity3 to @entity4 is correlated with the degree of @entity1 in the airway submucosa.

title: Airway responsiveness to XXXX in @entity2 is associated with chymase-positive mast cells and @entity1 .

answer: @entity4


abstract: BACKGROUND: @entity3 ( @entity3 ) to inhaled @entity4 is associated with indirect markers of mast cell activation and @entity1 . It is unknown how @entity3 to @entity4 relates to mast cell phenotype, mast cell function and measures of @entity1 in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell-associated genes and number of eosinophils in airway tissue of subjects with @entity2 and healthy controls in relation to @entity3 to @entity4 . METHODS: @entity3 to inhaled @entity4 was measured in 23 non-smoking, corticosteroid-free asthmatic individuals and 10 healthy controls. Mast cells and eosinophils were identified in mucosal biopsies from all @entity0 . Mast cells were divided into phenotypes based on the presence of chymase. mRNA expression of mast cell-associated genes was measured by real-time PCR. RESULTS: The proportion of submucosal MCTC was higher in asthmatic individuals with @entity3 to @entity4 compared with asthmatic individuals without @entity3 (median: 40.3% vs. 18.7%, P  =  0.03). Increased submucosal MCTC numbers were associated with increased levels of mRNA for @entity5 ( @entity5 ) and @entity6 in asthmatics. Reactivity to @entity4 correlated significantly with eosinophils in submucosa (r(s): 0.56, P  =  0.01). CONCLUSION: @entity3 to inhaled @entity4 is associated with an altered submucosal mast cell profile in asthmatic individuals. This mast cell profile is associated with increased levels of @entity5 and @entity6 . The degree of @entity3 to @entity4 is correlated with the degree of @entity1 in the airway submucosa.

title: Airway responsiveness to @entity4 in @entity2 is associated with chymase-positive mast cells and XXXX .

answer: @entity1


abstract: A disadvantage in Q fever diagnostics and research is the insensitive and difficult culture of @entity3 . This intracellular organism can only be isolated using embryonated eggs, animal hosts, or @entity0 cell culture. In consequence, it has only been possible to isolate a few strains from @entity0 @entity0 . Here, we describe the first isolation of @entity3 from a clinical specimen using the recently developed cell-free medium acidified citrate cysteine medium 2 (ACCM2). We screened the sera of 217 @entity0 who had undergone valvular transplantation but detected one serum with an antibody constellation indicating @entity2 . Polymerase chain reaction (PCR) of the corresponding heart valve revealed 3.1   *   10(5) copies/rxn. The strain was successfully isolated using ACCM2. Genomic investigation by multilocus variable-number of tandem repeat (VNTR) analysis (MLVA) revealed the strain to be a new genotype, A10, closely related to one from @entity1 . As the sensitivity of ACCM2 for different @entity0 strains is unknown, we also investigated combining a robust test, egg propagation, with ACCM2. This combination produced four to six logs of growth of the bacteria. The use of ACCM2 in this combination simplified the otherwise elaborate purification steps. Cultivation in ACCM2 has the potential to simplify the isolation of @entity3 in a clinical setting. As the success rates of cell culture for virulent @entity3 strains are variable, the sensitivity of ACCM2 for different strains is unknown, and many specimens may contain much fewer bacteria than in our case, the combination of the robust method of egg propagation with ACCM2 is a good alternative to existing single methods for investigating critical specimens.

title: First isolation of XXXX from clinical material by cell-free medium (ACCM2).

answer: @entity3


abstract: BACKGROUND: Visceral adiposity is a strong determinant of @entity7 resistance, which decreases @entity9 response sensitivity, and increases @entity4 saturation in the gallbladder bile; thus, it potentially relates to @entity8 development. We aimed to investigate whether visceral fat measured by computed tomography (CT) is a risk factor for @entity8 . METHODS: A cohort of 717 @entity0 undergoing CT and ultrasonography was analyzed. The associations between body mass index (BMI), @entity5 ( @entity5 ) area, @entity5 ( @entity5 ) area, and @entity8 were analyzed adjusted for age, sex, @entity3 , @entity1 , and @entity6 . RESULTS: In multivariate analysis, @entity8 was significantly associated with @entity5 and @entity5 areas for both categorical data and trend (P for trend <0.001, 0.009), but not BMI. Among @entity0 with BMI <25, @entity8 remained significantly associated with @entity5 area (P for trend 0.021) and @entity5 area (P for trend 0.005). Interactions between the @entity2 indices and being elderly on the risk of @entity8 were found; specifically BMI (P=0.005), @entity5 (P<0.001), and @entity5 (P=0.154). A significant association between all @entity2 indices and @entity8 was seen in @entity0 aged <65 but not among those aged >= 65. However, no significant association was noted between the @entity2 indices and sex. CONCLUSIONS: CT-measured adipose tissue, rather than BMI, was a better predictor for risk of @entity8 . This finding   applies to younger   @entity0 or even those with normal body weight,   suggesting the importance of abdominal visceral fat accumulation in the development of @entity8 .

title: Abdominal Visceral Fat Accumulation Measured by Computed Tomography is Associated with an Increased Risk of XXXX .

answer: @entity8


abstract: There is currently no standard technique to objectively quantify the microvascularization of @entity3 . Fractal analysis has been proposed as a useful descriptor of @entity1 microvascularity. Standardization of the fractal analysis methodology could offer a new tool for this type of characterization. In this study, we applied fractal analysis to the characterization of the different angioarchitectures found in specimens of @entity2 multiforme (GBM), the most common and most malignant type of @entity0 @entity3 . A retrospective series of 114 primary GBM specimens was carried out. To quantify neoplastic microvascularity, the level of two-dimensional geometrical complexity of the microvascular patterns was assessed using the box-counting algorithm, which estimates the microvascular fractal dimension (mvFD). mvFD makes information on the non-Euclidean space filled by vessels embedded in the @entity1 microenvironment available because it depends on vessel number, shape, magnitude and distribution pattern. A mean mvFD value of 1.44    0.17 (range: 1.06-1.87) was found. The coefficient of variation was 44%. The high geometric variability, found objectively, in these samples reflects the angioarchitectural heterogeneity underlying GBM. The present study shows that angioarchitectural subtypes can be identified by mvFD, making this parameter a potential tool for quantifying different neoplastic microvascular patterns.

title: Angioarchitectural heterogeneity in @entity0 XXXX multiforme: a fractal-based histopathological assessment.

answer: @entity2


abstract: There is currently no standard technique to objectively quantify the microvascularization of @entity3 . Fractal analysis has been proposed as a useful descriptor of @entity1 microvascularity. Standardization of the fractal analysis methodology could offer a new tool for this type of characterization. In this study, we applied fractal analysis to the characterization of the different angioarchitectures found in specimens of @entity2 multiforme (GBM), the most common and most malignant type of @entity0 @entity3 . A retrospective series of 114 primary GBM specimens was carried out. To quantify neoplastic microvascularity, the level of two-dimensional geometrical complexity of the microvascular patterns was assessed using the box-counting algorithm, which estimates the microvascular fractal dimension (mvFD). mvFD makes information on the non-Euclidean space filled by vessels embedded in the @entity1 microenvironment available because it depends on vessel number, shape, magnitude and distribution pattern. A mean mvFD value of 1.44    0.17 (range: 1.06-1.87) was found. The coefficient of variation was 44%. The high geometric variability, found objectively, in these samples reflects the angioarchitectural heterogeneity underlying GBM. The present study shows that angioarchitectural subtypes can be identified by mvFD, making this parameter a potential tool for quantifying different neoplastic microvascular patterns.

title: Angioarchitectural heterogeneity in XXXX @entity2 multiforme: a fractal-based histopathological assessment.

answer: @entity0


abstract: AIM: Managing @entity2 remains a challenging task, and adequate treatment strategies seem to be mandatory to avoid irreversible damage of the @entity1 . Two-stage revision arthroplasty includes removing all implants and subsequent implantation of an antibiotic-loaded cement spacer, followed by revision arthroplasty as the second stage. Although this procedure is well described in the literature, results remain unpredictable due to various clinical findings and the absence of prospective randomised trials. We analysed (1) mortality and (2) reinfection rates in a series of @entity0 who underwent two-stage revision surgery for periprosthetic @entity2 with antibiotic-augmented joint spacers. We maintained a special focus on the spacer retention period and its influence on outcome in order to determine the best time for second-stage surgery. @entity0 AND METHODS: A consecutive series of 76 @entity0 with native and periprosthetic @entity2 and who underwent two-stage revision surgery with antibiotic-loaded cement spacers were studied between 2005 and 2010. The second-stage operation was performed when it was assumed that @entity2 was eradicated. The further operative procedure depended upon intra-operative findings (frozen section, local status). RESULTS: Mean implant-free period with the antibiotic-loaded spacer in situ was 12.6  weeks. Spacer re-implantation was necessary in 13 cases due to positive signs of @entity3 in the frozen section and suspect intra-operative findings. Eight @entity0 were not operated for a second time in the investigated time period due to poor general condition. In 40 @entity0 , the spacer retention period was four to 11  weeks: <four  weeks for five and >11  weeks for 23. We observed a significantly higher proportion of @entity0 free from reinfection in the four to 11-week group than in @entity0 with the shorter or longer period. CONCLUSION: According to our findings, the optimal timing for second-stage surgery as a second-stage procedure is between four and 11 weeks. A significantly optimal reinfection rate was seen in @entity0 undergoing revision arthroplasty within that time frame, and 90  % of those @entity0 remained @entity2 free until final follow-up.

title: Two-stage revision of prosthetic XXXX using antibiotic-loaded cement spacers: When is the best time to perform the second stage?

answer: @entity2


abstract: UNASSIGNED: @entity1 guidelines propose home or ambulatory blood pressure monitoring as indispensable after office measurement. However, whether preference should be given to home or ambulatory monitoring remains undetermined. In 831 untreated outpatients (mean age, 50.6 years; 49.8% @entity0 ), we measured office (3 visits), home (7 days), and 24-h ambulatory blood pressures. We applied @entity1 guidelines for cross-classification of @entity0 into normotension or white-coat, masked, or sustained @entity1 . Based on office and home blood pressures, the prevalence of white-coat, masked, and sustained @entity1 was 61 (10.3%), 166 (20.0%), and 162 (19.5%), respectively. Using daytime (from 8 am to 6 pm) instead of home blood pressure confirmed the cross-classification in 575 @entity0 (69.2%), downgraded risk from masked @entity1 to normotension (n=24) or from sustained to white-coat @entity1 (n=9) in 33 (4.0%), but upgraded risk from normotension to masked @entity1 (n=179) or from white-coat to sustained @entity1 (n=44) in 223 (26.8%). Analyses based on 24-h ambulatory blood pressure were confirmatory. In adjusted analyses, both the urinary albumin-to- @entity2 ratio (+20.6%; confidence interval, 4.4-39.3) and aortic pulse wave velocity (+0.30 m/s; confidence interval, 0.09-0.51) were higher in @entity0 who moved up to a higher risk category. Both indexes of target organ damage and central augmentation index were positively associated (P <=0.048) with the odds of being reclassified. In conclusion, for reliably diagnosing @entity1 and starting treatment, office measurement should be followed by ambulatory blood pressure monitoring. Using home instead of ambulatory monitoring misses the high-risk diagnoses of masked or sustained @entity1 in over 25% of @entity0 .

title: Strategies for Classifying XXXX Based on Office, Home, and Ambulatory Blood Pressure Measurement.

answer: @entity0


abstract: UNASSIGNED: The depletion of @entity1 (DC) residues in eggs was determined after oral drug administration by drinking water to laying hens. The antibiotic was supplied to birds for 5 consecutive days and the eggs were collected during medication and 18  days after withdrawal. DC residues were determined by LC-MS/MS. DC was isolated from eggs with a solution of 0.02  M of @entity3 ( @entity2 ), 0.1  M @entity4 and @entity0 . The limit of detection (LOD) and limit of quantification (LOQ) of the method were 2 and 5    g  kg(-1), respectively. Analyses were performed on whole egg, egg white and yolk separately. DC was detectable 24  h after the beginning of administration. The concentration of antibiotic increased daily, resulting in the highest DC concentration in whole eggs at the first day of the withdrawal period. Thirteen days after withdrawal, the content of DC in whole eggs was below the LOQ of the method. However, some differences were found in the depletion curve of DC between egg white and yolk. Residues of DC in egg white were much higher during treatment and 1 day after withdrawal, but later the concentration in egg white decreased fairly rapidly and a higher DC content in egg yolk was observed. The depletion period was shorter for egg white than for yolk, and DC was detected in the egg white until 12  days after withdrawal and 2  days more in egg yolk than in white. DC reached a peak faster in egg white, but the residues were detectable for longer period in the yolk.

title: XXXX depletion and residues in eggs after oral administration to laying hens.

answer: @entity1


abstract: OBJECTIVE: To investigate whether @entity3 ( @entity4 ) treatment has beneficial effects on IVF results and pregnancy outcome in @entity1 @entity0 with @entity2 undergoing IVF/intracytoplasmic sperm injection (ICSI). DESIGN: Prospective, randomized trial. SETTING: University-affiliated @entity1 clinic. @entity0 (S): A total of 64 @entity1 @entity0 with @entity2 , defined as an elevated serum TSH level associated with a normal free T4 level and without frank symptoms of @entity2 . INTERVENTION(S): @entity0 were randomized into an @entity4 treatment group or control group. For the @entity4 treatment group, 50  g @entity4 was administered from the first day of controlled ovarian stimulation for IVF/ICSI. MAIN OUTCOME MEASURE(S): Results of IVF and pregnancy outcome. RESULT(S): There were no differences in @entity0 characteristics between the two groups. Total dose and days of recombinant @entity0 FSH used for controlled ovarian stimulation were also similar. The number of grade I or II embryos was significantly higher in the @entity4 treatment group than in the control group. There was no significant difference in the clinical pregnancy rate per cycle between the two groups. However, the miscarriage rate was significantly lower in the @entity4 treatment group than in the control group. Embryo implantation rate and live birth rate were significantly higher in the @entity4 treatment group. In the control group, both thyroid peroxidase antibody and thyroglobulin antibody levels were significantly higher in the miscarried subgroup than in the delivered subgroup. CONCLUSION(S): @entity4 treatment can improve embryo quality and pregnancy outcome in @entity2 @entity0 undergoing IVF/ICSI.

title: Effect of @entity3 treatment on in vitro fertilization and pregnancy outcome in XXXX @entity0 with @entity2 undergoing in vitro fertilization/intracytoplasmic sperm injection.

answer: @entity1


abstract: OBJECTIVE: To investigate whether @entity3 ( @entity4 ) treatment has beneficial effects on IVF results and pregnancy outcome in @entity1 @entity0 with @entity2 undergoing IVF/intracytoplasmic sperm injection (ICSI). DESIGN: Prospective, randomized trial. SETTING: University-affiliated @entity1 clinic. @entity0 (S): A total of 64 @entity1 @entity0 with @entity2 , defined as an elevated serum TSH level associated with a normal free T4 level and without frank symptoms of @entity2 . INTERVENTION(S): @entity0 were randomized into an @entity4 treatment group or control group. For the @entity4 treatment group, 50  g @entity4 was administered from the first day of controlled ovarian stimulation for IVF/ICSI. MAIN OUTCOME MEASURE(S): Results of IVF and pregnancy outcome. RESULT(S): There were no differences in @entity0 characteristics between the two groups. Total dose and days of recombinant @entity0 FSH used for controlled ovarian stimulation were also similar. The number of grade I or II embryos was significantly higher in the @entity4 treatment group than in the control group. There was no significant difference in the clinical pregnancy rate per cycle between the two groups. However, the miscarriage rate was significantly lower in the @entity4 treatment group than in the control group. Embryo implantation rate and live birth rate were significantly higher in the @entity4 treatment group. In the control group, both thyroid peroxidase antibody and thyroglobulin antibody levels were significantly higher in the miscarried subgroup than in the delivered subgroup. CONCLUSION(S): @entity4 treatment can improve embryo quality and pregnancy outcome in @entity2 @entity0 undergoing IVF/ICSI.

title: Effect of @entity3 treatment on in vitro fertilization and pregnancy outcome in @entity1 @entity0 with XXXX undergoing in vitro fertilization/intracytoplasmic sperm injection.

answer: @entity2


abstract: OBJECTIVE: To investigate whether @entity3 ( @entity4 ) treatment has beneficial effects on IVF results and pregnancy outcome in @entity1 @entity0 with @entity2 undergoing IVF/intracytoplasmic sperm injection (ICSI). DESIGN: Prospective, randomized trial. SETTING: University-affiliated @entity1 clinic. @entity0 (S): A total of 64 @entity1 @entity0 with @entity2 , defined as an elevated serum TSH level associated with a normal free T4 level and without frank symptoms of @entity2 . INTERVENTION(S): @entity0 were randomized into an @entity4 treatment group or control group. For the @entity4 treatment group, 50  g @entity4 was administered from the first day of controlled ovarian stimulation for IVF/ICSI. MAIN OUTCOME MEASURE(S): Results of IVF and pregnancy outcome. RESULT(S): There were no differences in @entity0 characteristics between the two groups. Total dose and days of recombinant @entity0 FSH used for controlled ovarian stimulation were also similar. The number of grade I or II embryos was significantly higher in the @entity4 treatment group than in the control group. There was no significant difference in the clinical pregnancy rate per cycle between the two groups. However, the miscarriage rate was significantly lower in the @entity4 treatment group than in the control group. Embryo implantation rate and live birth rate were significantly higher in the @entity4 treatment group. In the control group, both thyroid peroxidase antibody and thyroglobulin antibody levels were significantly higher in the miscarried subgroup than in the delivered subgroup. CONCLUSION(S): @entity4 treatment can improve embryo quality and pregnancy outcome in @entity2 @entity0 undergoing IVF/ICSI.

title: Effect of XXXX treatment on in vitro fertilization and pregnancy outcome in @entity1 @entity0 with @entity2 undergoing in vitro fertilization/intracytoplasmic sperm injection.

answer: @entity3


abstract: OBJECTIVE: To investigate whether @entity3 ( @entity4 ) treatment has beneficial effects on IVF results and pregnancy outcome in @entity1 @entity0 with @entity2 undergoing IVF/intracytoplasmic sperm injection (ICSI). DESIGN: Prospective, randomized trial. SETTING: University-affiliated @entity1 clinic. @entity0 (S): A total of 64 @entity1 @entity0 with @entity2 , defined as an elevated serum TSH level associated with a normal free T4 level and without frank symptoms of @entity2 . INTERVENTION(S): @entity0 were randomized into an @entity4 treatment group or control group. For the @entity4 treatment group, 50  g @entity4 was administered from the first day of controlled ovarian stimulation for IVF/ICSI. MAIN OUTCOME MEASURE(S): Results of IVF and pregnancy outcome. RESULT(S): There were no differences in @entity0 characteristics between the two groups. Total dose and days of recombinant @entity0 FSH used for controlled ovarian stimulation were also similar. The number of grade I or II embryos was significantly higher in the @entity4 treatment group than in the control group. There was no significant difference in the clinical pregnancy rate per cycle between the two groups. However, the miscarriage rate was significantly lower in the @entity4 treatment group than in the control group. Embryo implantation rate and live birth rate were significantly higher in the @entity4 treatment group. In the control group, both thyroid peroxidase antibody and thyroglobulin antibody levels were significantly higher in the miscarried subgroup than in the delivered subgroup. CONCLUSION(S): @entity4 treatment can improve embryo quality and pregnancy outcome in @entity2 @entity0 undergoing IVF/ICSI.

title: Effect of @entity3 treatment on in vitro fertilization and pregnancy outcome in @entity1 XXXX with @entity2 undergoing in vitro fertilization/intracytoplasmic sperm injection.

answer: @entity0


abstract: PURPOSE: Many @entity2 survivors experience compromised health-related quality of life (HRQOL) as a result of @entity2 . We examined relationships between types and intensities of activity and @entity2 -related HRQOL, overall, and by @entity1 , and treatment characteristics. METHODS: Associations between post-diagnosis activity and sedentary behavior and HRQOL domains ( @entity3 , @entity5 /hormonal) were prospectively examined in @entity0 diagnosed with non-metastatic @entity2 in the Health Professionals Follow-up Study (n   =   1917) using generalized linear models. RESULTS: After adjusting for potential confounders, higher duration of total, non-vigorous, and walking activity was associated with higher vitality/hormonal functioning scores (p-trends, <0.0001). Effects were small (d   =   0.16-0.20) but approached clinical significance for @entity0 in the highest vs. lowest activity categories. Survivors who walked >= 90  min/week at a normal pace, or faster, reported higher hormone/vitality scores (p   =   0.001) than @entity0 walking <90  min at an easy pace. Weightlifting was associated with increased @entity3 (p-trend, 0.02). Total activity was associated with higher hormone/vitality functioning in @entity0 who were >= 5  years post-treatment, had more @entity4 (Gleason score >= 7), and had >= 1 comorbid condition. No relationships were observed between vigorous activity or sedentary behavior and HRQOL. CONCLUSIONS: Increased duration of non-vigorous activity and walking post-diagnosis was positively associated with better hormone/vitality functioning. Specifically, engaging in >= 5  h of non-vigorous activity or >= 3  h of walking per week may be beneficial. IMPLICATIONS FOR CANCER SURVIVORS: Encouraging @entity0 to engage in non-vigorous activity and walking may be helpful for managing @entity2 .

title: Physical activity, sedentary behavior, and health-related quality of life in XXXX survivors in the health professionals follow-up study.

answer: @entity2


abstract: AIM: To determine the clinical and laboratory characteristics of @entity0 diagnosed with pediatric @entity4 (pSLE) in the general pediatrics department of a tertiary level hospital in southern India and compare them to data of case series from other parts of the country. METHODS: Retrospective chart review by two independent reviewers. All @entity0 diagnosed with @entity4 in the pediatrics department of the Amrita Institute of Medical Sciences hospital between 1 January 2004 and 31 September 2008, were included in the study. RESULTS: Twenty @entity0 were diagnosed with pSLE in the above-mentioned period (female : male ratio 2.3 : 1.0). @entity1 (75% of @entity0 ) and @entity7 (65%) were the most common clinical presenting features. Many @entity0 who were referred as ' @entity1 of unknown origin' (37.5%) or ' @entity6 ' (15%) fulfilled the diagnosis of @entity4 on detailed evaluation. Renal manifestations were present in 11 @entity0 , seven of whom underwent a biopsy. Class IV @entity5 was the most common finding (4/7). A very high percentage of our @entity0 had hypocomplementemia (85%). The statistical significance of the differences between our cohort and previously reported cohorts could not be determined. CONCLUSIONS: pSLE @entity0 in our series, compared to previous literature from India had a much higher incidence of @entity1 , @entity3 and hypocomplementemia at presentation and much lower incidence of @entity2 . It is unclear whether these differences represent unique characteristics of ethnically dissimilar subsets of the Indian population. A high index of suspicion should be maintained in order to make an early diagnosis of pSLE, since the most common presenting features in our cohort were @entity7 and @entity1 .

title: Case series of pediatric XXXX : comparison with other Indian series.

answer: @entity4


abstract: BACKGROUND: Data regarding anatomic and clinical results of flow diversion treatment in complex bifurcation @entity2 of the anterior circulation are scarce. OBJECTIVE: To present our results of treatment of these lesions with special emphasis on the fate of 'jailed' cortical branches and perforating arteries. METHODS: Seventeen @entity0 were treated with flow diverters (FDs) for 18 @entity2 of the middle cerebral artery bifurcation (n=13) and the anterior communicating artery complex (n=5). Nineteen cortical branches were covered. A single FD was used in all @entity0 . RESULTS: At latest follow-up (mean 7.9 months; range 3-36; median 4.0) 2/19 (10.5%) of the covered branches were occluded, 9/19 (47.4%) showed a decreased caliber and the remaining branches were unchanged. All branch modifications were clinically asymptomatic. Mortality and permanent morbidity were 0%. Symptomatic @entity1 events in perforator territories occurred in three @entity0 (17.6%), which were reversible in all of them within 24   h. Follow-up MRI disclosed asymptomatic @entity3 corresponding to covered perforating artery territories in five @entity0 (29.4%). Altogether, perforator lesions-symptomatic and asymptomatic-occurred in 7/17 @entity0 (41.2%). 33.3% of the @entity2 were occluded at latest follow-up; decreased diameters were seen in the other 66.7%. CONCLUSIONS: Flow diversion of bifurcation @entity2 is feasible with low rates of permanent morbidity and mortality. Caliber reduction and asymptomatic occlusion of covered cortical branches seems to be common, yet @entity1 complications are rather linked to perforator occlusions. Our results on @entity2 rates are preliminary and longer follow-up periods are warranted.

title: Flow diversion treatment of complex bifurcation XXXX beyond the circle of Willis: a single-center series with special emphasis on covered cortical branches and perforating arteries.

answer: @entity2


abstract: OBJECTIVE: The purpose of this study was to examine the effect of @entity0 produced by @entity4 on mass, myofibrillar protein content, and cross-sectional areas of Type I and II fibers of @entity1 hindlimb muscles. METHOD: Adult male @entity1 were assigned to one of three groups: a @entity3 group (n = 10) that underwent ligation and cut of the left L5 spinal nerve, a sham group (n = 10) that underwent a sham cut procedure, or a control group (n = 10) that underwent no procedures. The withdrawal threshold test was done to assess @entity3 threshold on each of Days 1-7 and 14. Activity, body weight, and food intake were measured daily for 2 weeks. At 15 days, @entity1 were anesthetized and the bilateral soleus, plantaris, and gastrocnemius muscles dissected. RESULTS: At 15 days post-ligation, the @entity3 group had significant decreases in total dietary intake, body weight, activity, and muscle weight as compared to sham and control animals. Muscle weight and cross-sectional area of Type II fiber of the ipsilateral soleus, plantaris, and gastrocnemius muscles decreased as did myofibrillar protein content of the @entity2 . Muscle weight of the contralateral gastrocnemius muscle decreased, as did myofibrillar protein content and cross-sectional area of Type II fiber of the contralateral plantaris muscle. CONCLUSION: Hindlimb @entity5 occurs in both ipsilateral and contralateral sides following induction of @entity0 by unilateral @entity4 . Muscle changes of the ipsilateral side are more pronounced than those of the contralateral side.

title: Hindlimb XXXX occurs from @entity4 in a @entity1 @entity0 model.

answer: @entity5


abstract: OBJECTIVE: The purpose of this study was to examine the effect of @entity0 produced by @entity4 on mass, myofibrillar protein content, and cross-sectional areas of Type I and II fibers of @entity1 hindlimb muscles. METHOD: Adult male @entity1 were assigned to one of three groups: a @entity3 group (n = 10) that underwent ligation and cut of the left L5 spinal nerve, a sham group (n = 10) that underwent a sham cut procedure, or a control group (n = 10) that underwent no procedures. The withdrawal threshold test was done to assess @entity3 threshold on each of Days 1-7 and 14. Activity, body weight, and food intake were measured daily for 2 weeks. At 15 days, @entity1 were anesthetized and the bilateral soleus, plantaris, and gastrocnemius muscles dissected. RESULTS: At 15 days post-ligation, the @entity3 group had significant decreases in total dietary intake, body weight, activity, and muscle weight as compared to sham and control animals. Muscle weight and cross-sectional area of Type II fiber of the ipsilateral soleus, plantaris, and gastrocnemius muscles decreased as did myofibrillar protein content of the @entity2 . Muscle weight of the contralateral gastrocnemius muscle decreased, as did myofibrillar protein content and cross-sectional area of Type II fiber of the contralateral plantaris muscle. CONCLUSION: Hindlimb @entity5 occurs in both ipsilateral and contralateral sides following induction of @entity0 by unilateral @entity4 . Muscle changes of the ipsilateral side are more pronounced than those of the contralateral side.

title: Hindlimb @entity5 occurs from XXXX in a @entity1 @entity0 model.

answer: @entity4


abstract: OBJECTIVE: The purpose of this study was to examine the effect of @entity0 produced by @entity4 on mass, myofibrillar protein content, and cross-sectional areas of Type I and II fibers of @entity1 hindlimb muscles. METHOD: Adult male @entity1 were assigned to one of three groups: a @entity3 group (n = 10) that underwent ligation and cut of the left L5 spinal nerve, a sham group (n = 10) that underwent a sham cut procedure, or a control group (n = 10) that underwent no procedures. The withdrawal threshold test was done to assess @entity3 threshold on each of Days 1-7 and 14. Activity, body weight, and food intake were measured daily for 2 weeks. At 15 days, @entity1 were anesthetized and the bilateral soleus, plantaris, and gastrocnemius muscles dissected. RESULTS: At 15 days post-ligation, the @entity3 group had significant decreases in total dietary intake, body weight, activity, and muscle weight as compared to sham and control animals. Muscle weight and cross-sectional area of Type II fiber of the ipsilateral soleus, plantaris, and gastrocnemius muscles decreased as did myofibrillar protein content of the @entity2 . Muscle weight of the contralateral gastrocnemius muscle decreased, as did myofibrillar protein content and cross-sectional area of Type II fiber of the contralateral plantaris muscle. CONCLUSION: Hindlimb @entity5 occurs in both ipsilateral and contralateral sides following induction of @entity0 by unilateral @entity4 . Muscle changes of the ipsilateral side are more pronounced than those of the contralateral side.

title: Hindlimb @entity5 occurs from @entity4 in a @entity1 XXXX model.

answer: @entity0


abstract: OBJECTIVE: The purpose of this study was to examine the effect of @entity0 produced by @entity4 on mass, myofibrillar protein content, and cross-sectional areas of Type I and II fibers of @entity1 hindlimb muscles. METHOD: Adult male @entity1 were assigned to one of three groups: a @entity3 group (n = 10) that underwent ligation and cut of the left L5 spinal nerve, a sham group (n = 10) that underwent a sham cut procedure, or a control group (n = 10) that underwent no procedures. The withdrawal threshold test was done to assess @entity3 threshold on each of Days 1-7 and 14. Activity, body weight, and food intake were measured daily for 2 weeks. At 15 days, @entity1 were anesthetized and the bilateral soleus, plantaris, and gastrocnemius muscles dissected. RESULTS: At 15 days post-ligation, the @entity3 group had significant decreases in total dietary intake, body weight, activity, and muscle weight as compared to sham and control animals. Muscle weight and cross-sectional area of Type II fiber of the ipsilateral soleus, plantaris, and gastrocnemius muscles decreased as did myofibrillar protein content of the @entity2 . Muscle weight of the contralateral gastrocnemius muscle decreased, as did myofibrillar protein content and cross-sectional area of Type II fiber of the contralateral plantaris muscle. CONCLUSION: Hindlimb @entity5 occurs in both ipsilateral and contralateral sides following induction of @entity0 by unilateral @entity4 . Muscle changes of the ipsilateral side are more pronounced than those of the contralateral side.

title: Hindlimb @entity5 occurs from @entity4 in a XXXX @entity0 model.

answer: @entity1


abstract: BACKGROUND: Laparoscopic Nissen fundoplication (LNF) is the most frequently performed operation for @entity2 ( @entity2 ). However, 12% of the @entity0 have persistent reflux symptoms and 19% develop gas-related symptoms after LNF. Weakly acidic reflux and inability to belch have been alleged to cause these symptoms, respectively. The effect of LNF on weakly acidic reflux and (supra) gastric @entity4 was evaluated. METHODS: In 31 @entity0 upper @entity1 , stationary oesophageal manometry and 24-h impedance-pH monitoring off acid secretion inhibiting drugs was performed before and 6 months after primary LNF for @entity2 that was refractory to proton pump inhibitors. @entity0 filled out validated questionnaires on GERD-HRQoL before and 3, 6 and 12 months after surgery. RESULTS: LNF reduced reflux symptoms (18.6 > 1.6; p = 0.015). The procedure drastically reduced the incidence (number per 24 h) of acid (76.0 > 1.6; p < 0.001) and weakly acidic (13.6 > 5.7; p = 0.001) as well as liquid (53.4 > 5.4; p<0.001) and mixed @entity3 (36.3 > 1.9; p < 0.001). In contrast, gas reflux was reduced to lesser extent (35.6 > 25.7; p = 0.022). Proximal, mid-oesophageal and distal reflux were reduced to a similar extent. Persistent @entity2 symptoms were neither preceded by acid nor by weakly acidic reflux. The number of air swallows did not change, but the number of gastric belches (GBs) was greatly reduced (68.5 > 23.9; p < 0.001). Twenty-three @entity0 had supragastric belches (SGBs), both before and after surgery, whereas eight @entity0 had no SGBs at all. The majority of SGBs were not reflux associated and the frequency was greatly increased after LNF (20.8 > 46.0; p = 0.036). Reflux-associated SGBs were abolished after surgery (14.0 > 0.4; p < 0.001). CONCLUSIONS: LNF similarly controls acid and weakly acidic reflux, but gas reflux is reduced to lesser extent. Persistent reflux symptoms are neither caused by acid nor by weakly acidic reflux. LNF alters the @entity4 pattern by reducing GBs (air venting from stomach) and increasing SGBs (no air venting from stomach). This explains the increase in @entity4 experienced by some @entity0 after LNF, despite the reduction in gastric @entity4 . It can be hypothesised that the reduction in GBs after LNF incites @entity0 to increase SGBs in a futile attempt to vent air from the stomach.

title: Effects of anti-reflux surgery on weakly acidic reflux and XXXX .

answer: @entity4


abstract: BACKGROUND: Cardiac involvement in @entity2 is often silent and may lead to @entity4 . This study was designed to assess the value of programmed electric stimulation of the ventricle (PES) for risk stratification in @entity0 with @entity2 and evidence of preclinical cardiac involvement on imaging studies. METHODS AND RESULTS: @entity0 with biopsy-proven systemic @entity2 but without cardiac symptoms who had evidence of @entity1 on positron emission tomography (PET) or cardiac MRI (CMR) were included. All @entity0 underwent baseline evaluation, echocardiographic assessment of left ventricular function, and programmed electric stimulation of the ventricle. @entity0 were followed for survival and arrhythmic events. Seventy-six @entity0 underwent PES of the ventricle. Eight (11%) were inducible for sustained @entity3 and received an implantable defibrillator. None of the noninducible @entity0 received a defibrillator. Left ventricular ejection fraction was lower in @entity0 with inducible @entity3 (36.4  4.2% versus 55.8  1.5%, P<0.05). Over a median follow-up of 5 years, 6 of 8 @entity0 in the group with inducible @entity3 had @entity3 or died, compared with 1 death in the negative group (P<0.0001). CONCLUSIONS: In @entity0 with biopsy-proven @entity2 and evidence of cardiac involvement on PET or CMR alone, positive PES may help to identify @entity0 at risk for @entity3 . More importantly, @entity0 in this cohort with a negative PES appear to have a benign course within the first several years following diagnosis. PES may help to guide the use of implantable cardioverter defibrillators in this population.

title: Primary prevention of sudden cardiac death in silent XXXX : role of programmed ventricular stimulation.

answer: @entity1


abstract: BACKGROUND: A low serum osteocalcin level, @entity2 and postmenopausal status are recognized risk factors for @entity1 . OBJECTIVE: We investigated the relationship between the serum osteocalcin level and visceral fat content in a population of Chinese postmenopausal @entity0 . DESIGN AND @entity0 : In total, 1481 postmenopausal @entity0 (mean age      standard deviation, 57  1      4  8  years) were selected from the Shanghai Obesity Study. MEASUREMENTS: Abdominal fat accumulation was quantified using magnetic resonance imaging. Subjects with a @entity3 ( @entity3 ) of >= 80  cm(2) were classified as abdominally obese. The total serum osteocalcin level was measured by electrochemiluminescence immunoassay. RESULTS: The median serum osteocalcin level was 20  66   g/l (interquartile range, 16  88-25  42   g/l). The overall prevalence of @entity2 was 49  1% (n  =  727). @entity2 subjects had lower serum osteocalcin levels than did nonabdominally obese subjects [19  14 (16  02-23  82) vs 21  97 (18  14-26  77)  g/l, respectively; P  <  0  001]. Partial correlation analysis showed that the serum osteocalcin level was still negatively correlated with @entity3 after adjusting for age, years since menopause and body mass index (P  <  0  01). Moreover, @entity3 was independently associated with the serum osteocalcin level after adjustment for confounding factors (P  <  0  05). A low serum osteocalcin level was an independent risk factor for @entity2 (odds ratio, 0  972; 95% confidence interval, 0  953-0  991; P  =  0  004). CONCLUSION: The serum osteocalcin level was inversely correlated with the visceral fat content in these Chinese postmenopausal @entity0 .

title: Association between serum osteocalcin level and XXXX in Chinese postmenopausal @entity0 .

answer: @entity2


abstract: BACKGROUND: A low serum osteocalcin level, @entity2 and postmenopausal status are recognized risk factors for @entity1 . OBJECTIVE: We investigated the relationship between the serum osteocalcin level and visceral fat content in a population of Chinese postmenopausal @entity0 . DESIGN AND @entity0 : In total, 1481 postmenopausal @entity0 (mean age      standard deviation, 57  1      4  8  years) were selected from the Shanghai Obesity Study. MEASUREMENTS: Abdominal fat accumulation was quantified using magnetic resonance imaging. Subjects with a @entity3 ( @entity3 ) of >= 80  cm(2) were classified as abdominally obese. The total serum osteocalcin level was measured by electrochemiluminescence immunoassay. RESULTS: The median serum osteocalcin level was 20  66   g/l (interquartile range, 16  88-25  42   g/l). The overall prevalence of @entity2 was 49  1% (n  =  727). @entity2 subjects had lower serum osteocalcin levels than did nonabdominally obese subjects [19  14 (16  02-23  82) vs 21  97 (18  14-26  77)  g/l, respectively; P  <  0  001]. Partial correlation analysis showed that the serum osteocalcin level was still negatively correlated with @entity3 after adjusting for age, years since menopause and body mass index (P  <  0  01). Moreover, @entity3 was independently associated with the serum osteocalcin level after adjustment for confounding factors (P  <  0  05). A low serum osteocalcin level was an independent risk factor for @entity2 (odds ratio, 0  972; 95% confidence interval, 0  953-0  991; P  =  0  004). CONCLUSION: The serum osteocalcin level was inversely correlated with the visceral fat content in these Chinese postmenopausal @entity0 .

title: Association between serum osteocalcin level and @entity2 in Chinese postmenopausal XXXX .

answer: @entity0


abstract: @entity7 ( @entity7 ), an independent risk factor for @entity3 , is associated with abnormal lipoprotein metabolism. We examined whether electronegative low-density lipoprotein (LDL) is mechanistically linked to @entity4 in @entity0 with early @entity7 . We compared echocardiographic parameters between @entity0 with stage 2 @entity7 (n = 88) and normal controls (n = 89) and found that impaired relaxation was more common in @entity7 @entity0 . Reduction in estimated glomerular filtration rate was an independent predictor of @entity9 . We then examined cardiac function in a @entity2 model of early @entity7 induced by unilateral nephrectomy (UNx) by analyzing pressure-volume loop data. The time constant of isovolumic pressure decay was longer and the maximal velocity of pressure fall was slower in UNx @entity2 than in controls. When we investigated the mechanisms underlying @entity5 , we found that LDL from @entity7 @entity0 and UNx @entity2 was more electronegative than LDL from their respective controls and that LDL from UNx @entity2 induced intracellular @entity6 overload in H9c2 cardiomyocytes in vitro. Furthermore, chronic administration of electronegative LDL, which signals through @entity11 ( @entity11 ), induced @entity5 in wild-type but not @entity11 (-/-) @entity1 . In in vitro and in vivo experiments, @entity4 was associated with increased @entity6 transient resulting from @entity8 (NO)-dependent nitrosylation of SERCA2a due to increases in inducible NO synthase expression and endothelial NO synthase uncoupling. In conclusion, LDL becomes more electronegative in early @entity7 . This change disrupts SERCA2a-regulated @entity6 homeostasis, which may be the mechanism underlying @entity10 .

title: Increased LDL electronegativity in chronic kidney disease disrupts XXXX homeostasis resulting in @entity4 .

answer: @entity6


abstract: @entity7 ( @entity7 ), an independent risk factor for @entity3 , is associated with abnormal lipoprotein metabolism. We examined whether electronegative low-density lipoprotein (LDL) is mechanistically linked to @entity4 in @entity0 with early @entity7 . We compared echocardiographic parameters between @entity0 with stage 2 @entity7 (n = 88) and normal controls (n = 89) and found that impaired relaxation was more common in @entity7 @entity0 . Reduction in estimated glomerular filtration rate was an independent predictor of @entity9 . We then examined cardiac function in a @entity2 model of early @entity7 induced by unilateral nephrectomy (UNx) by analyzing pressure-volume loop data. The time constant of isovolumic pressure decay was longer and the maximal velocity of pressure fall was slower in UNx @entity2 than in controls. When we investigated the mechanisms underlying @entity5 , we found that LDL from @entity7 @entity0 and UNx @entity2 was more electronegative than LDL from their respective controls and that LDL from UNx @entity2 induced intracellular @entity6 overload in H9c2 cardiomyocytes in vitro. Furthermore, chronic administration of electronegative LDL, which signals through @entity11 ( @entity11 ), induced @entity5 in wild-type but not @entity11 (-/-) @entity1 . In in vitro and in vivo experiments, @entity4 was associated with increased @entity6 transient resulting from @entity8 (NO)-dependent nitrosylation of SERCA2a due to increases in inducible NO synthase expression and endothelial NO synthase uncoupling. In conclusion, LDL becomes more electronegative in early @entity7 . This change disrupts SERCA2a-regulated @entity6 homeostasis, which may be the mechanism underlying @entity10 .

title: Increased LDL electronegativity in chronic kidney disease disrupts @entity6 homeostasis resulting in XXXX .

answer: @entity4


abstract: BACKGROUND: The use of @entity2 analogues (SAs) following pancreaticoduodenectomy (PD) is controversial. METHOD: Literature databases were searched systematically for relevant articles. A meta-analysis of all randomized controlled trials (RCTs) evaluating prophylactic SAs in PD was performed. RESULTS: Fifteen RCTs involving 1,352 @entity0 were included. There was a towards reduced incidences of @entity4 (p = 0.26), clinically significant @entity4 (p = 0.08), and @entity1 (p = 0.05) in prophylactic SAs group. In subgroup analyses, prophylactic @entity2 significantly reduced the incidence of @entity4 (p = 0.02), with a nonsignificant trend toward reduced incidence of clinically significantly @entity4 (p = 0.06). @entity5 significantly reduced the incidence of clinically significantly @entity4 (p = 0.03). @entity3 had no influence on the incidence of @entity4 . CONCLUSION: The current best evidence suggests prophylactic treatment with @entity2 or @entity5 has a potential role in reducing the incidence of @entity4 , while @entity3 had no influence on the incidence of @entity4 . High-quality RCTs assessing the role of @entity2 and @entity5 are required for further verification.    2015 S. Karger AG, Basel.

title: Systematic Review and Meta-Analysis of XXXX Analogues in the Prevention of Postoperative Complication after Pancreaticoduodenectomy.

answer: @entity2


abstract: BACKGROUND AND AIMS: In photosynthetic organisms exposure to high light induces the production of reactive @entity0 species (ROS), such as @entity1 ( @entity3 ), which in part is prevented by non-photochemical quenching (NPQ). As one of the most stable and longest-lived ROS, @entity3 is involved in key signalling pathways in development and stress responses, although in excess it can induce damage. A ubiquitous response to high light is the induction of the xanthophyll cycle, but its role in algae is unclear as it is not always associated with NPQ induction. The aim of this study was to reveal how diurnal changes in the level of @entity3 are regulated in a freshwater algal community. METHODS: A natural freshwater community of algae in a temporary rainwater pool was studied, comprising photosynthetic Euglena species, benthic Navicula diatoms, Chlamydomonas and Chlorella species. Diurnal measurements were made of photosynthetic performance, concentrations of photosynthetic pigments and @entity3 . The frequently studied model organisms Chlamydomonas and Chlorella species were isolated to study photosynthesis-related @entity3 responses to high light. KEY RESULTS: NPQ was shown to prevent @entity3 release in Chlamydomonas and Chlorella species under high light; in addition, dissolved organic @entity2 excited by UV-B radiation was probably responsible for a part of the @entity3 produced in the water column. Concentrations of @entity3 peaked at 2     m at midday and algae rapidly scavenged @entity3 rather than releasing it. A vertical @entity3 gradient was observed that was lowest next to diatom-rich benthic algal mats. The diurnal changes in photosynthetic pigments included the @entity4 and @entity5 cycles; the former was induced prior to the latter, but neither was strictly correlated with NPQ. CONCLUSIONS: The diurnal cycling of @entity3 was apparently modulated by the organisms in this freshwater algal community. Although the community showed flexibility in its levels of NPQ, the diurnal changes in xanthophylls correlated with @entity3 concentrations. Alternative NPQ mechanisms in algae involving proteins of the light-harvesting complex type and antioxidant protection of the thylakoid membrane by de-epoxidized carotenoids are discussed.

title: Diurnal changes in the xanthophyll cycle pigments of freshwater algae correlate with the environmental XXXX concentration rather than non-photochemical quenching.

answer: @entity1


abstract: The antinociceptive effect of @entity3 (CPC) and @entity4 were examined in adjuvant arthritic @entity0 . In the behavioral study, @entity2 (100-400 mg/kg, p.o.) but not @entity4 (100-400 mg/kg, p.o.) had a dose-dependent antinociceptive effect, determined using the flexion test. In the electrophysiological study, CPC (25-50 mg/kg, i.v.) but not @entity4 (50 mg/kg, i.v.) @entity1 the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB), while the evoked responses of non-nociceptive neurons were not @entity1 by either CPC (50 mg/kg, i.v.) or @entity4 (50 mg/kg, i.v.). The spontaneous firings of the VB nociceptive neurons were @entity1 by both CPC (50 mg/kg, i.v.) and @entity4 (50 mg/kg, i.v.). However, @entity4 (50 mg/kg, i.v.) but not CPC (50 mg/kg, i.v.) also @entity1 the spontaneous firings of the mesencephalic reticular formation (RF), in these adjuvant arthritic @entity0 . These results indicate that CPC but not @entity4 , has an antinociceptive action in adjuvant arthritic @entity0 .

title: Antinociceptive effect of XXXX in adjuvant arthritic @entity0 .

answer: @entity3


abstract: The antinociceptive effect of @entity3 (CPC) and @entity4 were examined in adjuvant arthritic @entity0 . In the behavioral study, @entity2 (100-400 mg/kg, p.o.) but not @entity4 (100-400 mg/kg, p.o.) had a dose-dependent antinociceptive effect, determined using the flexion test. In the electrophysiological study, CPC (25-50 mg/kg, i.v.) but not @entity4 (50 mg/kg, i.v.) @entity1 the evoked neuronal responses of nociceptive neurons in the ventrobasal thalamus (VB), while the evoked responses of non-nociceptive neurons were not @entity1 by either CPC (50 mg/kg, i.v.) or @entity4 (50 mg/kg, i.v.). The spontaneous firings of the VB nociceptive neurons were @entity1 by both CPC (50 mg/kg, i.v.) and @entity4 (50 mg/kg, i.v.). However, @entity4 (50 mg/kg, i.v.) but not CPC (50 mg/kg, i.v.) also @entity1 the spontaneous firings of the mesencephalic reticular formation (RF), in these adjuvant arthritic @entity0 . These results indicate that CPC but not @entity4 , has an antinociceptive action in adjuvant arthritic @entity0 .

title: Antinociceptive effect of @entity3 in adjuvant arthritic XXXX .

answer: @entity0


abstract: BACKGROUND: Radiostereometric analysis provides highly precise measurements of component micromotion relative to the bone that is otherwise undetectable by routine radiographs. This study compared, at a minimum of five years following surgery, the micromotion of @entity4 and @entity3 acetabular cups and femoral head penetration in highly cross-linked @entity2 liners and conventional (ultra-high molecular weight @entity2 ) liners in active @entity0 who had undergone total hip replacement. METHODS: This institutional review board-approved prospective, randomized, blinded study involved forty-six @entity0 . @entity0 were randomized into one of four cohorts according to both acetabular cup and @entity2 liner. @entity0 received either a cementless cup with a @entity3 mesh surface or a @entity4 trabecular surface and either a highly cross-linked @entity2 liner or an ultra-high molecular weight @entity2 liner. Radiostereometric analysis examinations and Short Form-36 Physical Component Summary, Western Ontario and McMaster Universities @entity1 Index (WOMAC), University of California Los Angeles (UCLA) activity, and Harris hip scores were obtained preoperatively, postoperatively, at six months, and annually thereafter. RESULTS: All @entity0 had significant improvement (p < 0.05) in Short Form-36 Physical Component Summary, WOMAC, UCLA activity, and Harris hip scores postoperatively. On radiostereometric analysis examination, highly cross-linked @entity2 liners showed significantly less median femoral head penetration at five years (p < 0.05). Steady-state wear rates from one year to five years were 0.04 mm per year for ultra-high molecular weight @entity2 liners and 0.004 mm per year for highly cross-linked @entity2 liners. At the five-year follow-up, the median migration (and standard error) was 0.05    0.20 mm proximally for @entity3 cups and 0.21    0.05 mm for @entity4 cups. CONCLUSIONS: In this young population who had undergone total hip replacement, radiostereometric analysis showed significantly less femoral head penetration in the highly cross-linked @entity2 liners compared with that in the conventional ultra-high molecular weight @entity2 liners. Penetration rates were one order of magnitude less in highly cross-linked @entity2 liners compared with ultra-high molecular weight @entity2 liners. There was no significant difference in proximal migration between the @entity4 and @entity3 acetabular cups through the five-year follow-up (p > 0.19).

title: Radiostereometric analysis study of @entity4 compared with XXXX acetabular cups and highly cross-linked compared with conventional liners in young @entity0 undergoing total hip replacement.

answer: @entity3


abstract: BACKGROUND: Radiostereometric analysis provides highly precise measurements of component micromotion relative to the bone that is otherwise undetectable by routine radiographs. This study compared, at a minimum of five years following surgery, the micromotion of @entity4 and @entity3 acetabular cups and femoral head penetration in highly cross-linked @entity2 liners and conventional (ultra-high molecular weight @entity2 ) liners in active @entity0 who had undergone total hip replacement. METHODS: This institutional review board-approved prospective, randomized, blinded study involved forty-six @entity0 . @entity0 were randomized into one of four cohorts according to both acetabular cup and @entity2 liner. @entity0 received either a cementless cup with a @entity3 mesh surface or a @entity4 trabecular surface and either a highly cross-linked @entity2 liner or an ultra-high molecular weight @entity2 liner. Radiostereometric analysis examinations and Short Form-36 Physical Component Summary, Western Ontario and McMaster Universities @entity1 Index (WOMAC), University of California Los Angeles (UCLA) activity, and Harris hip scores were obtained preoperatively, postoperatively, at six months, and annually thereafter. RESULTS: All @entity0 had significant improvement (p < 0.05) in Short Form-36 Physical Component Summary, WOMAC, UCLA activity, and Harris hip scores postoperatively. On radiostereometric analysis examination, highly cross-linked @entity2 liners showed significantly less median femoral head penetration at five years (p < 0.05). Steady-state wear rates from one year to five years were 0.04 mm per year for ultra-high molecular weight @entity2 liners and 0.004 mm per year for highly cross-linked @entity2 liners. At the five-year follow-up, the median migration (and standard error) was 0.05    0.20 mm proximally for @entity3 cups and 0.21    0.05 mm for @entity4 cups. CONCLUSIONS: In this young population who had undergone total hip replacement, radiostereometric analysis showed significantly less femoral head penetration in the highly cross-linked @entity2 liners compared with that in the conventional ultra-high molecular weight @entity2 liners. Penetration rates were one order of magnitude less in highly cross-linked @entity2 liners compared with ultra-high molecular weight @entity2 liners. There was no significant difference in proximal migration between the @entity4 and @entity3 acetabular cups through the five-year follow-up (p > 0.19).

title: Radiostereometric analysis study of XXXX compared with @entity3 acetabular cups and highly cross-linked compared with conventional liners in young @entity0 undergoing total hip replacement.

answer: @entity4


abstract: BACKGROUND: Radiostereometric analysis provides highly precise measurements of component micromotion relative to the bone that is otherwise undetectable by routine radiographs. This study compared, at a minimum of five years following surgery, the micromotion of @entity4 and @entity3 acetabular cups and femoral head penetration in highly cross-linked @entity2 liners and conventional (ultra-high molecular weight @entity2 ) liners in active @entity0 who had undergone total hip replacement. METHODS: This institutional review board-approved prospective, randomized, blinded study involved forty-six @entity0 . @entity0 were randomized into one of four cohorts according to both acetabular cup and @entity2 liner. @entity0 received either a cementless cup with a @entity3 mesh surface or a @entity4 trabecular surface and either a highly cross-linked @entity2 liner or an ultra-high molecular weight @entity2 liner. Radiostereometric analysis examinations and Short Form-36 Physical Component Summary, Western Ontario and McMaster Universities @entity1 Index (WOMAC), University of California Los Angeles (UCLA) activity, and Harris hip scores were obtained preoperatively, postoperatively, at six months, and annually thereafter. RESULTS: All @entity0 had significant improvement (p < 0.05) in Short Form-36 Physical Component Summary, WOMAC, UCLA activity, and Harris hip scores postoperatively. On radiostereometric analysis examination, highly cross-linked @entity2 liners showed significantly less median femoral head penetration at five years (p < 0.05). Steady-state wear rates from one year to five years were 0.04 mm per year for ultra-high molecular weight @entity2 liners and 0.004 mm per year for highly cross-linked @entity2 liners. At the five-year follow-up, the median migration (and standard error) was 0.05    0.20 mm proximally for @entity3 cups and 0.21    0.05 mm for @entity4 cups. CONCLUSIONS: In this young population who had undergone total hip replacement, radiostereometric analysis showed significantly less femoral head penetration in the highly cross-linked @entity2 liners compared with that in the conventional ultra-high molecular weight @entity2 liners. Penetration rates were one order of magnitude less in highly cross-linked @entity2 liners compared with ultra-high molecular weight @entity2 liners. There was no significant difference in proximal migration between the @entity4 and @entity3 acetabular cups through the five-year follow-up (p > 0.19).

title: Radiostereometric analysis study of @entity4 compared with @entity3 acetabular cups and highly cross-linked compared with conventional liners in young XXXX undergoing total hip replacement.

answer: @entity0


abstract: @entity2 ( @entity2 ) are rare inherited primary @entity2 that are mainly due to abnormalities of muscle energy metabolism resulting in skeletal @entity2 . These diseases include @entity1 , glyco(geno) @entity2 and mitochondrial @entity6 . Clinically these disorders present with a range of symptoms including infantile @entity7 , @entity5 /exercise tolerance, chronic or acute @entity4 , cramps/ @entity8 /stiffness or @entity9 acute @entity12 . The precipitant may be fasting, @entity3 , general anaesthesia, heat/cold or most commonly, exercise. However, the differential diagnosis includes a wide range of both acquired and inherited conditions and these include exposure to drugs/toxins, @entity11 , @entity10 and @entity14 . Streamlining of existing diagnostic protocols has now become a realistic prospect given the availability of second-generation sequencing. A diagnostic pathway using a ' @entity12 ' gene panel at an early stage of the diagnostic process is proposed. Following detailed clinical evaluation and first-line investigations, some @entity0 will be identified as candidates for @entity13 / @entity13 or MRC disease and these will be referred directly to the specialised services. However, for the majority of @entity0 , second-line investigation is best undertaken through next-generation sequencing using a ' @entity12 ' gene panel. Following molecular analysis and careful evaluation of the findings, some @entity0 will receive a clear diagnosis. Further functional or specific targeted testing may be required in other @entity0 to evaluate the significance of uncertain/equivocal findings. For @entity0 with no clear diagnosis, further investigations will be required through a specialist centre.

title: The investigation and management of XXXX .

answer: @entity2


abstract: PURPOSE: In early clinical testing, most novel targeted anticancer therapies have limited @entity3 and limited efficacy, which complicates dose and schedule selection for these agents. Confirmation of target inhibition is critical for rational drug development; however, repeated @entity1 biopsies are often impractical and peripheral blood mononuclear cells and normal skin are often inadequate surrogates for @entity1 tissue. Based upon the similarities of @entity1 and wound stroma, we have developed a clinical dermal granulation tissue model to evaluate novel targeted therapies. EXPERIMENTAL DESIGN: A 4-mm skin punch biopsy was used to stimulate wound healing and a repeat 5-mm punch biopsy was used to harvest the resulting granulation tissue. This assay was performed at pretreatment and on-treatment evaluating four targeted therapies, bevacizumab, @entity6 , @entity8 , and panitumumab, in the context of three different clinical trials. Total and phosphorylated levels @entity4 , S6RP, and @entity5 were evaluated using ELISA-based methodologies. RESULTS: Significant and consistent inhibition of the @entity2 pathway (using @entity4 as the readout) was observed in granulation tissue biopsies from @entity0 treated with bevacizumab and @entity6 . In addition, significant and consistent inhibition of the @entity7 pathway (using S6RP as the readout) was observed in @entity0 treated with @entity6 . Finally, significant inhibition of the @entity5 pathway (using @entity5 as the readout) was observed in @entity0 treated with panitumumab, but this was not observed in @entity0 treated with @entity8 . CONCLUSION: Molecular analyses of dermal granulation tissue can be used as a convenient and quantitative pharmacodynamic biomarker platform for multiple classes of targeted therapies. Clin Cancer Res; 1-11.   2015 AACR.

title: Direct Evidence of Target Inhibition with Anti- XXXX , @entity5 , and @entity7 Therapies in a Clinical Model of Wound Healing.

answer: @entity2


abstract: PURPOSE: In early clinical testing, most novel targeted anticancer therapies have limited @entity3 and limited efficacy, which complicates dose and schedule selection for these agents. Confirmation of target inhibition is critical for rational drug development; however, repeated @entity1 biopsies are often impractical and peripheral blood mononuclear cells and normal skin are often inadequate surrogates for @entity1 tissue. Based upon the similarities of @entity1 and wound stroma, we have developed a clinical dermal granulation tissue model to evaluate novel targeted therapies. EXPERIMENTAL DESIGN: A 4-mm skin punch biopsy was used to stimulate wound healing and a repeat 5-mm punch biopsy was used to harvest the resulting granulation tissue. This assay was performed at pretreatment and on-treatment evaluating four targeted therapies, bevacizumab, @entity6 , @entity8 , and panitumumab, in the context of three different clinical trials. Total and phosphorylated levels @entity4 , S6RP, and @entity5 were evaluated using ELISA-based methodologies. RESULTS: Significant and consistent inhibition of the @entity2 pathway (using @entity4 as the readout) was observed in granulation tissue biopsies from @entity0 treated with bevacizumab and @entity6 . In addition, significant and consistent inhibition of the @entity7 pathway (using S6RP as the readout) was observed in @entity0 treated with @entity6 . Finally, significant inhibition of the @entity5 pathway (using @entity5 as the readout) was observed in @entity0 treated with panitumumab, but this was not observed in @entity0 treated with @entity8 . CONCLUSION: Molecular analyses of dermal granulation tissue can be used as a convenient and quantitative pharmacodynamic biomarker platform for multiple classes of targeted therapies. Clin Cancer Res; 1-11.   2015 AACR.

title: Direct Evidence of Target Inhibition with Anti- @entity2 , XXXX , and @entity7 Therapies in a Clinical Model of Wound Healing.

answer: @entity5