abstract: PURPOSE: To evaluate long-term safety and efficacy of iStent trabecular micro-bypass stent implantation during @entity1 surgery in @entity0 with primary open-angle, @entity5 , @entity4 , or secondary or post-traumatic @entity3 . SETTING: AaM Augenklinik am Marienplatz, Munich, Germany. DESIGN: Prospective, open-label, non-randomized study. METHODS: Preoperative and postoperative evaluations included intra-ocular pressure (IOP), @entity2 medication use, cup/disc ratio, corrected-distance visual acuity (CDVA), complications, and adverse events. RESULTS: A single trabecular micro-bypass stent was implanted through the same temporal, limbal incision used for @entity1 surgery via phacoemulsification in a consecutive series of 62 eyes of 43 @entity0 . To date, a total of 41 eyes have been followed for 3  years postoperatively, whereas long-term postoperative follow-up on the remaining @entity0 is ongoing. Mean preoperative IOP was 24.1      6.9 mm Hg on a mean of 1.8 medications (  0.9). Analyses of eyes with no secondary surgical intervention showed mean IOP reduction to 14.8      4.2 mm Hg at 12  months (n  =  61), 14.5      2.2 mm Hg at 24  months (n  =  42), and 14.9      2.3 mm Hg at 36  months (n  =  39). Medications were eliminated in 74% of eyes at 36  months. Five eyes, 4 with previous @entity3 surgeries and 1 with @entity5 , required additional @entity3 surgery after stent implantation. No intra-operative or postoperative complications typically seen with conventional @entity3 surgeries occurred after stent implantation. At 36  months, CDVA was 20/40 or better in 38 eyes (93%). CONCLUSION: Trabecular micro-bypass stent implantation during @entity1 surgery was safe and effective in @entity0 with @entity4 or @entity3 as measured by a sustained reduction in IOP and medication use and an excellent safety profile through 3  years after surgery. FINANCIAL DISCLOSURES: Dr. Neuhann has no financial or proprietary interest in any material or method mentioned. Glaukos Corp. provided editorial assistance in the preparation of the manuscript.

title: Trabecular micro-bypass stent implantation during small-incision XXXX surgery for open-angle glaucoma or @entity4 : Long-term results.

answer: @entity1


abstract: CONTEXT: The terrorist attacks on Israeli society have been ongoing since September 2000. However, few studies have examined the impact of @entity5 on nationally representative population samples, and no study has examined the psychological impact of ongoing @entity5 in Israel. OBJECTIVES: To determine the level of exposure to terrorist attacks and the prevalence of traumatic stress-related (TSR) symptoms, symptoms of @entity4 ( @entity4 ), and sense of safety after 19 months of @entity5 in Israel, and to identify correlates of the psychological sequelae and the modes of coping with the @entity5 . DESIGN, SETTING, AND @entity0 : Telephone survey conducted April-May 2002, using a strata sampling method, of 902 eligible households and a representative sample of 742 Israeli residents older than 18 years (82% contact rate) and a final participation of 512 (57%). MAIN OUTCOME MEASURES: Number of TSR symptoms, rates of those with symptom criteria for @entity4 and @entity6 assessed by the Stanford Acute Stress Reaction Questionnaire, self-reported feelings of @entity3 , optimism, sense of safety, help-seeking, and modes of coping. RESULTS: Of 512 survey @entity0 , 84 (16.4%) had been directly exposed to a terrorist attack and 191 (37.3%) had a family member or friend who had been exposed. Of 510 @entity0 who responded to questions about TSR symptoms, 391 (76.7%) had at least 1 TSR symptom (mean, 4.0 [SD, 4.5]; range, 0-23; mean intensity, 0.8; range, 0-4). Symptom criteria for @entity4 were met by 48 @entity0 (9.4%) and criteria for @entity6 , by 1 @entity0 ; 299 (58.6%) reported feeling @entity3 . The majority of respondents expressed optimism about their personal future (421/512 [82.2%]) and the future of Israel (307/509 [66.8%]), and expressed self-efficacy with regard to their ability to function in a terrorist attack (322/431 [74.6%]). Most expressed a low sense of safety with respect to themselves (307/509 [60.4%]) and their relatives (345/507 [67.9%]). Few reported a need for professional help (27/506 [5.3%]). Female sex, sense of safety, and use of tranquilizers, @entity2 , and cigarettes to cope were associated with TSR symptoms and symptom criteria for @entity4 ; level of exposure and objective risk were not. The most prevalent coping mechanisms were active information search about loved ones and social support. CONCLUSIONS: Considering the nature and length of the Israeli traumatic experience, the psychological impact may be considered moderate. Although the survey @entity0 showed distress and lowered sense of safety, they did not develop high levels of @entity1 , which may be related to a habituation process and to coping mechanisms.

title: Exposure to XXXX , stress-related mental health symptoms, and @entity1 among a nationally representative sample in Israel.

answer: @entity5


abstract: CONTEXT: The terrorist attacks on Israeli society have been ongoing since September 2000. However, few studies have examined the impact of @entity5 on nationally representative population samples, and no study has examined the psychological impact of ongoing @entity5 in Israel. OBJECTIVES: To determine the level of exposure to terrorist attacks and the prevalence of traumatic stress-related (TSR) symptoms, symptoms of @entity4 ( @entity4 ), and sense of safety after 19 months of @entity5 in Israel, and to identify correlates of the psychological sequelae and the modes of coping with the @entity5 . DESIGN, SETTING, AND @entity0 : Telephone survey conducted April-May 2002, using a strata sampling method, of 902 eligible households and a representative sample of 742 Israeli residents older than 18 years (82% contact rate) and a final participation of 512 (57%). MAIN OUTCOME MEASURES: Number of TSR symptoms, rates of those with symptom criteria for @entity4 and @entity6 assessed by the Stanford Acute Stress Reaction Questionnaire, self-reported feelings of @entity3 , optimism, sense of safety, help-seeking, and modes of coping. RESULTS: Of 512 survey @entity0 , 84 (16.4%) had been directly exposed to a terrorist attack and 191 (37.3%) had a family member or friend who had been exposed. Of 510 @entity0 who responded to questions about TSR symptoms, 391 (76.7%) had at least 1 TSR symptom (mean, 4.0 [SD, 4.5]; range, 0-23; mean intensity, 0.8; range, 0-4). Symptom criteria for @entity4 were met by 48 @entity0 (9.4%) and criteria for @entity6 , by 1 @entity0 ; 299 (58.6%) reported feeling @entity3 . The majority of respondents expressed optimism about their personal future (421/512 [82.2%]) and the future of Israel (307/509 [66.8%]), and expressed self-efficacy with regard to their ability to function in a terrorist attack (322/431 [74.6%]). Most expressed a low sense of safety with respect to themselves (307/509 [60.4%]) and their relatives (345/507 [67.9%]). Few reported a need for professional help (27/506 [5.3%]). Female sex, sense of safety, and use of tranquilizers, @entity2 , and cigarettes to cope were associated with TSR symptoms and symptom criteria for @entity4 ; level of exposure and objective risk were not. The most prevalent coping mechanisms were active information search about loved ones and social support. CONCLUSIONS: Considering the nature and length of the Israeli traumatic experience, the psychological impact may be considered moderate. Although the survey @entity0 showed distress and lowered sense of safety, they did not develop high levels of @entity1 , which may be related to a habituation process and to coping mechanisms.

title: Exposure to @entity5 , stress-related mental health symptoms, and XXXX among a nationally representative sample in Israel.

answer: @entity1


abstract: BACKGROUND: On-going @entity1 transmission is increasingly mediated by outdoor-biting vectors, especially where indoor insecticidal interventions such as long-lasting insecticide treated nets (LLINs) are widespread. Often, the vectors are also physiologically resistant to insecticides, presenting major obstacles for elimination. We tested a combination of electrocuting grids with synthetic odours as an alternative killing mechanism against outdoor-biting mosquitoes. METHODS: An odour-baited device, the Mosquito Landing Box (MLB), was improved by fitting it with low-cost electrocuting grids to instantly kill mosquitoes attracted to the odour lure, and automated photo switch to activate attractant-dispensing and mosquito-killing systems between dusk and dawn. MLBs fitted with one, two or three electrocuting grids were compared outdoors in a @entity1 endemic village in Tanzania, where vectors had lost susceptibility to @entity2 . MLBs with three grids were also tested in a large semi-field cage (9.6*9.6*4.5m), to assess effects on biting-densities of laboratory-reared Anopheles arabiensis on volunteers sitting near MLBs. RESULTS: Significantly more mosquitoes were killed when MLBs had two or three grids, than one grid in wet and dry seasons (P<0.05). The MLBs were highly efficient against Mansonia species and @entity1 vector, An. arabiensis. Of all mosquitoes, 99% were non-blood fed, suggesting host-seeking status. In the semi-field, the MLBs reduced mean number of @entity1 mosquitoes attempting to bite @entity0 fourfold. CONCLUSION: The improved odour-baited MLBs effectively kill outdoor-biting @entity1 vector mosquitoes that are behaviourally and physiologically resistant to insecticidal interventions e.g. LLINs. The MLBs reduce @entity0 -biting vector densities even when used close to @entity0 , and are insecticide-free, hence potentially antiresistance. The devices could either be used as surveillance tools or complementary mosquito control interventions to accelerate @entity1 elimination where outdoor transmission is significant.

title: Combining Synthetic XXXX Odours and Low-Cost Electrocuting Grids to Attract and Kill Outdoor-Biting Mosquitoes: Field and Semi-Field Evaluation of an Improved Mosquito Landing Box.

answer: @entity0


abstract: CONTEXT: Studies suggested a potential value of preablative stimulated Tg (ps-Tg) on predicting the recurrent and persistent diseases of @entity1 ( @entity1 ), whereas its correlations with therapeutic response remain uncertain. OBJECTIVE: To establish the correlation between ps-Tg and therapeutic response proposed in 2015 American Thyroid Association (ATA) guidelines, and calculate a cut-off ps-Tg threshold for predicting a poor response. DESIGN/SETTING: @entity0 who underwent total thyroidectomy and radioactive @entity2 (RAI) therapy in a University hospital participated in this retrospective study. @entity0 : Totally, 452 @entity1 @entity0 were followed for a median of 38 months and were divided into three groups in terms of ps-Tg level: Group1:<1ng/ml (n=82), Group2: 1-10ng/ml (n=173), Group3:>= 10ng/ml (n=197). MAIN OUTCOME MEASURE: Clinical outcomes were assessed based on response to therapy re-staging system, dividing response into excellent (ER), indeterminate (IDR), biomedical incomplete (BIR), and structural incomplete (SIR). RESULTS: Therapeutic responses could be obviously distinguished by different ps-Tg strata. SIR was identified in none of Group 1, 1.73% of Group 2, and 42.74% of Group 3, respectively ((2)=123.037, p<0.001). A cut-off value of ps-Tg at 26.75 ng/ml was obtained by receiver operating characteristic (ROC) curve for differentiating SIR from either ER, IDR, or BIR. The area under curve (AUC) was 0.947 and negative predictive value (NPV) was 96.99%. Ps-Tg was an independent predictive variable of SIR (OR: 42.312, p<0.001). CONCLUSIONS: Ps-Tg has a great performance in predicting therapeutic response and providing incremental value for decision making of RAI therapy, especially for @entity0 with high ps-Tg level.

title: Preablative stimulated thyroglobulin correlates to new therapy response system in XXXX .

answer: @entity1


abstract: The acute @entity2 of @entity7 (CMT) was studied in @entity0 . CMT was found to produce @entity4 and @entity6 . The ED50s for @entity4 were 32 mg/kg (95% C.I. 24-42 mg/kg) p.o. and 20 mg/kg (95% C.I. 15-26 mg/kg) i.p. The LD50s for p.o. and i.p. administration were 22 mg/kg (95% C.I. 19-26 mg/kg) and 14 mg/kg (95% C.I. 10-20 mg/kg), respectively. Approximately 13-16% of the administered dose was recovered in the urine from 0 to 48 h post-dosing. The majority of this material was present as an organometallic form of @entity5 other than CMT. @entity1 pretreatment prevented the @entity4 and @entity3 produced by a 50 mg/kg i.p. dose of CMT. @entity0 pretreated with CMT (5 mg/kg, i.p.) for 3 days exhibited @entity4 but no deaths after treatment with a 34 mg/kg p.o. dose of CMT. These results suggest that CMT does not require metabolic activation to produce toxic effects, and that prior exposure to CMT produces tolerance.

title: The acute XXXX of @entity7 in the @entity0 .

answer: @entity2


abstract: The acute @entity2 of @entity7 (CMT) was studied in @entity0 . CMT was found to produce @entity4 and @entity6 . The ED50s for @entity4 were 32 mg/kg (95% C.I. 24-42 mg/kg) p.o. and 20 mg/kg (95% C.I. 15-26 mg/kg) i.p. The LD50s for p.o. and i.p. administration were 22 mg/kg (95% C.I. 19-26 mg/kg) and 14 mg/kg (95% C.I. 10-20 mg/kg), respectively. Approximately 13-16% of the administered dose was recovered in the urine from 0 to 48 h post-dosing. The majority of this material was present as an organometallic form of @entity5 other than CMT. @entity1 pretreatment prevented the @entity4 and @entity3 produced by a 50 mg/kg i.p. dose of CMT. @entity0 pretreated with CMT (5 mg/kg, i.p.) for 3 days exhibited @entity4 but no deaths after treatment with a 34 mg/kg p.o. dose of CMT. These results suggest that CMT does not require metabolic activation to produce toxic effects, and that prior exposure to CMT produces tolerance.

title: The acute @entity2 of XXXX in the @entity0 .

answer: @entity7


abstract: The acute @entity2 of @entity7 (CMT) was studied in @entity0 . CMT was found to produce @entity4 and @entity6 . The ED50s for @entity4 were 32 mg/kg (95% C.I. 24-42 mg/kg) p.o. and 20 mg/kg (95% C.I. 15-26 mg/kg) i.p. The LD50s for p.o. and i.p. administration were 22 mg/kg (95% C.I. 19-26 mg/kg) and 14 mg/kg (95% C.I. 10-20 mg/kg), respectively. Approximately 13-16% of the administered dose was recovered in the urine from 0 to 48 h post-dosing. The majority of this material was present as an organometallic form of @entity5 other than CMT. @entity1 pretreatment prevented the @entity4 and @entity3 produced by a 50 mg/kg i.p. dose of CMT. @entity0 pretreated with CMT (5 mg/kg, i.p.) for 3 days exhibited @entity4 but no deaths after treatment with a 34 mg/kg p.o. dose of CMT. These results suggest that CMT does not require metabolic activation to produce toxic effects, and that prior exposure to CMT produces tolerance.

title: The acute @entity2 of @entity7 in the XXXX .

answer: @entity0


abstract: BACKGROUND: Exaggerated postprandial @entity5 concentration is believed to be atherogenic, and to influence the risk of @entity6 . Both elevated @entity8 ( @entity8 ) and increased factor VII coagulant activity (FVIIc) are potential important contributors to the increased risk of @entity2 in @entity3 2 @entity1 . AIM: We aimed to investigate the effect of adding four different protein types (i.e. casein, whey, cod, and gluten) to a fat-rich meal on postprandial responses of @entity8 and FVIIc in @entity3 2 @entity1 @entity0 . METHODS: Twelve @entity3 2 @entity1 @entity0 ingested four isocaloric test meals in random order. The test meals contained 100 g of butter and 45 g of @entity7 in combination with 45 g of casein (Cas-meal), whey (Whe-meal), cod (Cod-meal), or gluten ( @entity4 -meal), respectively. Plasma concentrations of @entity8 and FVIIc were measured before meal, and at regular intervals for 8-h postprandially. RESULTS: The postprandial @entity8 concentration decreased significantly by 49% to 56% in response to the four test meals. There were no significant differences between the outcomes from the four test-meals. The FVIIc levels decreased by 8% to 11% after the meals. Again, we observed no significant differences in outcomes between the four protein-enriched meals. CONCLUSIONS: The four proteins casein, whey, cod, and gluten, added to a fat-rich meal, all decreased the @entity8 and FVIIc concentrations postprandially in @entity3 2 @entity1 subjects. However, postprandial levels of @entity8 and FVIIc were not acutely influenced by the protein source.

title: Effects of different protein sources on plasminogen inhibitor-1 and factor VII coagulant activity added to a fat-rich meal in XXXX 2 @entity1 .

answer: @entity3


abstract: BACKGROUND: Exaggerated postprandial @entity5 concentration is believed to be atherogenic, and to influence the risk of @entity6 . Both elevated @entity8 ( @entity8 ) and increased factor VII coagulant activity (FVIIc) are potential important contributors to the increased risk of @entity2 in @entity3 2 @entity1 . AIM: We aimed to investigate the effect of adding four different protein types (i.e. casein, whey, cod, and gluten) to a fat-rich meal on postprandial responses of @entity8 and FVIIc in @entity3 2 @entity1 @entity0 . METHODS: Twelve @entity3 2 @entity1 @entity0 ingested four isocaloric test meals in random order. The test meals contained 100 g of butter and 45 g of @entity7 in combination with 45 g of casein (Cas-meal), whey (Whe-meal), cod (Cod-meal), or gluten ( @entity4 -meal), respectively. Plasma concentrations of @entity8 and FVIIc were measured before meal, and at regular intervals for 8-h postprandially. RESULTS: The postprandial @entity8 concentration decreased significantly by 49% to 56% in response to the four test meals. There were no significant differences between the outcomes from the four test-meals. The FVIIc levels decreased by 8% to 11% after the meals. Again, we observed no significant differences in outcomes between the four protein-enriched meals. CONCLUSIONS: The four proteins casein, whey, cod, and gluten, added to a fat-rich meal, all decreased the @entity8 and FVIIc concentrations postprandially in @entity3 2 @entity1 subjects. However, postprandial levels of @entity8 and FVIIc were not acutely influenced by the protein source.

title: Effects of different protein sources on plasminogen inhibitor-1 and factor VII coagulant activity added to a fat-rich meal in @entity3 2 XXXX .

answer: @entity1


abstract: OBJECTIVE: The purpose of the study was to assess patterns of primary pancreatic lesions by contrast-enhanced sonography for differentiating @entity3 from other @entity5 . METHODS: One hundred six consecutive @entity0 with pancreatic masses, consisting of 83 @entity2 , 5 intraductal papillary mucinous @entity1 , 3 cases of autoimmune-related @entity5 , 3 solid @entity1 , 2 cases of chronic @entity5 , 1 @entity7 , 1 @entity6 , and 1 @entity4 , were examined by contrast-enhanced sonography with coded harmonic imaging in a phase inversion harmonic technique. The contrast enhancement patterns were assessed, and specimens removed during pancreatectomy were subjected to pathologic examination. RESULTS: Internal tumoral vascularity was detected in 47 (56.6%) of the 83 @entity3 . Vascular image spreading and homogeneous staining throughout the @entity1 were observed in all endocrine @entity2 . Two of the 5 intraductal papillary mucinous @entity1 were positive for enhancement effects. Enhancement effects were observed in all 3 cases of autoimmune-related @entity5 , but the degree varied. There was a significant correlation between the intensity of enhancement effects and the ratio of patent vessels in the @entity1 (P < .05). CONCLUSIONS: Vascularity was detected by contrast-enhanced sonography in only about half of the @entity3 , confirming the difficulty in distinguishing those @entity1 from other @entity5 . There was a correlation between the patency of the vessels in the @entity1 and their vascularity.

title: Evaluation of contrast enhancement patterns in XXXX by coded harmonic sonographic imaging with a microbubble contrast agent.

answer: @entity5


abstract: BACKGROUND: @entity4 ( @entity4 ) immunotherapy has proven efficacy in treating @entity2 ( @entity2 ) symptoms. This trial evaluated the dose-response relationship of SLIToneULTRA   @entity4 mix based on immunological parameters and safety in subjects with moderate-to-severe @entity4 @entity2 not controlled by symptomatic medication. MATERIALS AND METHODS: A randomized, parallel-group, open-label, clinical trial compared 50/150/300 standard reactivity unit (SRU) doses of SLIToneULTRA   @entity4 mix for 6 months. Subjects had moderate-to-severe @entity4 @entity2 , positive skin prick and IgE against @entity5 / @entity6 (DP/DF). The primary end point was change from baseline in the IgE-blocking factor against DP after 6 months. Secondary end points measured changes in the IgE-blocking factor for DP at 3 months and for DF at 3 and 6 months, and in IgG4 and specific IgE to DP/DF after 3 and 6 months. Tolerability was assessed through the evaluation of all adverse events (AEs). RESULTS: A total of 219 subjects were randomized and 196 completed the trial. Dose effect was significant on DP IgE-BF after 6 months (p = 0.018). The change in the DP IgE-blocking factor at a 300-SRU dose was higher than at other doses after 3 (p = 0.008) and 6 (p = 0005) months of treatment. Similar changes were observed for IgG4 and allergen-specific IgE. The number of AEs increased with the dose and were mild-to-moderate, with no severe treatment-related AEs reported. The most frequent AEs were @entity3 , mouth @entity0 and @entity1 . CONCLUSIONS: Data showed a dose-response for immunological markers and safety with a better immunological response for 300 SRU. The highest dose (300 SRU daily) was considered as the optimal maintenance dose.

title: Dose-Dependent Immunological Responses after a 6-Month Course of Sublingual House Dust Mite Immunotherapy in Patients with XXXX .

answer: @entity2


abstract: OBJECTIVE: To evaluate the results of TSRH instrumentation in the correction of coronal, sagittal and @entity1 of @entity2 . METHODS: From January 1998 to December 1999, thirty-two consecutive @entity0 (6 males, 26 females)with @entity2 underwent anterior or posterior spinal instrumentation and fusion using TSRH instrumentation. Of these cases, 21 were @entity3 and 11 were @entity2 . The average age at surgery was 16.4 years (range, 11 approximately 45 years). The mean Cobb angle at surgery was 71.2 degrees range, 44 degrees approximately 125 degrees) in the coronal plane, and 49. degrees range, 16 degrees aprroximately 67degrees in the sagittal plane. @entity1 (Nash-Moe) ranged from I to III degree. Preoperative apical translation averaged 4.8 cm (range, 3 approximately 9 cm). RESULTS: The average follow-up duration was 13.3 months (range, 10 approximately 24 months). At the final follow-up, the mean Cobb angle in the coronal plane was 26.6 (range, 10 degrees approximately 73 degrees), with a 63.8% of improvement. Sagittal alignment was well maintained with a mean Cobb angle of 28 degrees (range, 10 degrees approximatelky 45 degrees). The average correction of rotation of the apical vertebra was I degree. The average apical translation was 1.6 cm (range, 0.5 approximately 5.0 cm) representing a correction rate of 66, 7%. Complication was noted in two cases with an incidence of 3.1%, one case had superficial infection and the other one had lower hook dislocation. There was no neurologic deficit and pseudoarthrodesis in this series. CONCLUSION: TSRH instrumentation is an effective and convenient three-dimensional correction system with a lower rate of complication, which can not only correct the @entity1 , but maintain the sagittal alignment as well.

title: Three-dimensional correction of XXXX using TSRH instrumentation.

answer: @entity2


abstract: PURPOSE: Acute dislocation of the peroneal tendon is caused by massive combined flexion-torsion @entity1 supported by preexisting @entity3 of the ankle joint. This study aimed to investigate the clinical outcome of combined treatment of peroneal @entity2 and lateral and medial @entity3 . METHODS: Between 2005 and 2007, forty-two @entity0 with peroneal @entity2 and coexisting @entity3 were treated. The superior extensor retinaculum was reconstructed using anchor technique and periosteal flap repair, whereas the preexisting @entity3 with regard to the extensor inferior retinaculum was addressed using anchor reconstruction. All @entity0 underwent arthroscopy prior to surgery. Thirty-eight of a total of 42 @entity0 (aged 17-31) completed the 24-month follow-up. Clinical and arthroscopic examination was accomplished consistently by always the same two surgeons. Postoperative follow-up comprised clinical evaluation after 3, 6, 12 and 24 months. RESULTS: Clinical results showed a significant (P<0.0001) increase in the AOFAS-Hindfoot Score as an often used but not validated outcome measure, as well as a significant decrease in the Visual Analogue Scale and in the internal and external rotation, after 3 months. The clinical outcome was confirmed at the 6-, 12- and 24-months measuring points. No dislocation of the peroneal tendon recurred within the 24-month follow-up. Subjective @entity0 satisfaction was stated as high. CONCLUSIONS: Combined treatment of peroneal @entity2 and coexisting lateral and medial @entity3 in the ankle joint following arthroscopy results in good clinical outcome and high @entity0 satisfaction. LEVEL OF EVIDENCE: Case series, Level IV.

title: Treatment of peroneal @entity2 and coexisting medial and lateral XXXX in the ankle joint.

answer: @entity3


abstract: PURPOSE: Acute dislocation of the peroneal tendon is caused by massive combined flexion-torsion @entity1 supported by preexisting @entity3 of the ankle joint. This study aimed to investigate the clinical outcome of combined treatment of peroneal @entity2 and lateral and medial @entity3 . METHODS: Between 2005 and 2007, forty-two @entity0 with peroneal @entity2 and coexisting @entity3 were treated. The superior extensor retinaculum was reconstructed using anchor technique and periosteal flap repair, whereas the preexisting @entity3 with regard to the extensor inferior retinaculum was addressed using anchor reconstruction. All @entity0 underwent arthroscopy prior to surgery. Thirty-eight of a total of 42 @entity0 (aged 17-31) completed the 24-month follow-up. Clinical and arthroscopic examination was accomplished consistently by always the same two surgeons. Postoperative follow-up comprised clinical evaluation after 3, 6, 12 and 24 months. RESULTS: Clinical results showed a significant (P<0.0001) increase in the AOFAS-Hindfoot Score as an often used but not validated outcome measure, as well as a significant decrease in the Visual Analogue Scale and in the internal and external rotation, after 3 months. The clinical outcome was confirmed at the 6-, 12- and 24-months measuring points. No dislocation of the peroneal tendon recurred within the 24-month follow-up. Subjective @entity0 satisfaction was stated as high. CONCLUSIONS: Combined treatment of peroneal @entity2 and coexisting lateral and medial @entity3 in the ankle joint following arthroscopy results in good clinical outcome and high @entity0 satisfaction. LEVEL OF EVIDENCE: Case series, Level IV.

title: Treatment of peroneal XXXX and coexisting medial and lateral @entity3 in the ankle joint.

answer: @entity2


abstract: OBJECTIVE: To introduce a new spinal internal fixation system, @entity3 ( @entity3 ), and to investigate its early clinical outcomes. METHODS: The preliminary clinical outcomes of 15 @entity0 with thoracolumbar or lumbar @entity5 treated by anterior spinal fusion with @entity3 instrumentation were studied retrospectively. Fourteen @entity0 were diagnosed as @entity6 and 1 as @entity7 . RESULTS: Preoperatively, the Cobb's angle on the coronal plane was 55.8 degrees (range 35 degrees to approximately 78 degrees), and 14 degrees postoperatively, with an average correction of 74.8%. The average unfused thoracical curve was 35.9 degrees preoperatively (range 26 degrees to approximately 51 degrees) and 21.8 degrees (10 degrees to approximately 42 degrees) postoperatively, with 40% correction. The sagittal curve of lumbar was kept physiologically, preoperative 27.9 degrees and postoperative 25.7 degrees respectively. The trunk shift was 13.4 mm (5 to approximately 28 mm) preoperatively and 3.5 mm (0 to approximately 7 mm) postoperatively. The averaged apic vertebra derivation was 47.8 mm (21 to approximately 69 mm) before operation and 10.8 mm (3 to approximately 20 mm) after operation. The distance of C7 to center sacrum vertical line (CSVL) was 19.5 mm (16 to approximately 42) preoperatively and 11.3 mm (0 to approximately 32 mm) postoperatively. The apical vertebra rotation was 3 degree in 15 @entity0 preoperatively, and were improved to normal in 10 @entity0 , 1 degree in 4 @entity0 , and 2 degree in 1 @entity0 postoperatively. None had @entity1 and @entity2 . Only 1 @entity0 complained a cool feeling in the low extremity of concave side, and the symptom vanished at 3-month followed up. CONCLUSION: If used appropriately, @entity3 anterior spinal system is a good teatment for low thoracic or @entity4 .

title: Anterior spinal fusion with @entity3 instrumentation for XXXX .

answer: @entity5


abstract: OBJECTIVE: To introduce a new spinal internal fixation system, @entity3 ( @entity3 ), and to investigate its early clinical outcomes. METHODS: The preliminary clinical outcomes of 15 @entity0 with thoracolumbar or lumbar @entity5 treated by anterior spinal fusion with @entity3 instrumentation were studied retrospectively. Fourteen @entity0 were diagnosed as @entity6 and 1 as @entity7 . RESULTS: Preoperatively, the Cobb's angle on the coronal plane was 55.8 degrees (range 35 degrees to approximately 78 degrees), and 14 degrees postoperatively, with an average correction of 74.8%. The average unfused thoracical curve was 35.9 degrees preoperatively (range 26 degrees to approximately 51 degrees) and 21.8 degrees (10 degrees to approximately 42 degrees) postoperatively, with 40% correction. The sagittal curve of lumbar was kept physiologically, preoperative 27.9 degrees and postoperative 25.7 degrees respectively. The trunk shift was 13.4 mm (5 to approximately 28 mm) preoperatively and 3.5 mm (0 to approximately 7 mm) postoperatively. The averaged apic vertebra derivation was 47.8 mm (21 to approximately 69 mm) before operation and 10.8 mm (3 to approximately 20 mm) after operation. The distance of C7 to center sacrum vertical line (CSVL) was 19.5 mm (16 to approximately 42) preoperatively and 11.3 mm (0 to approximately 32 mm) postoperatively. The apical vertebra rotation was 3 degree in 15 @entity0 preoperatively, and were improved to normal in 10 @entity0 , 1 degree in 4 @entity0 , and 2 degree in 1 @entity0 postoperatively. None had @entity1 and @entity2 . Only 1 @entity0 complained a cool feeling in the low extremity of concave side, and the symptom vanished at 3-month followed up. CONCLUSION: If used appropriately, @entity3 anterior spinal system is a good teatment for low thoracic or @entity4 .

title: Anterior spinal fusion with XXXX instrumentation for @entity5 .

answer: @entity3


abstract: BACKGROUND: The aim of this study was to compare two different sympathicotomy procedures for primary @entity2 in terms of @entity3 , complications, safety and effectiveness. METHODS: The data of 78 consecutive @entity0 who underwent bilateral endoscopic thoracic sympathicotomy (156 laterals) for @entity2 between January 2005 and September 2009 were studied retrospectively. The first 29 consecutive @entity0 were treated with a T2-3 sympathicotomy (Group A). After November 2007, all @entity0 (49 @entity0 ) were treated with a T3 sympathicotomy alone (Group B). The chest tubes were always removed after checking for pneumothorax with roentgenography. All @entity0 were followed up and evaluated for results, side effects, complications, and satisfaction levels. The differences between the two groups were analyzed. RESULTS: The mean age of the 47 (60.2%) female and 31 (39.8%) male @entity0 was 25.2 years. @entity4 and pneumothorax was not detected in either group. The mean follow-up time was 20.82 months (6-52 months). Effectiveness of the procedure at the time of discharge and at follow-up was 100% and 97.5%, respectively. There was no significant difference between groups with regard to any analyzed parameter. CONCLUSION: This study demonstrates that preserving the T2 ganglion is safe, and does not compromise the effectiveness of the procedure. Sympathicotomy has the same success rate as sympathectomy, but requires significantly less dissection and results in less tissue @entity1 .

title: Preserving T2 in thoracic sympathicotomy for XXXX : less tissue @entity1 , same effectiveness.

answer: @entity2


abstract: BACKGROUND: The aim of this study was to compare two different sympathicotomy procedures for primary @entity2 in terms of @entity3 , complications, safety and effectiveness. METHODS: The data of 78 consecutive @entity0 who underwent bilateral endoscopic thoracic sympathicotomy (156 laterals) for @entity2 between January 2005 and September 2009 were studied retrospectively. The first 29 consecutive @entity0 were treated with a T2-3 sympathicotomy (Group A). After November 2007, all @entity0 (49 @entity0 ) were treated with a T3 sympathicotomy alone (Group B). The chest tubes were always removed after checking for pneumothorax with roentgenography. All @entity0 were followed up and evaluated for results, side effects, complications, and satisfaction levels. The differences between the two groups were analyzed. RESULTS: The mean age of the 47 (60.2%) female and 31 (39.8%) male @entity0 was 25.2 years. @entity4 and pneumothorax was not detected in either group. The mean follow-up time was 20.82 months (6-52 months). Effectiveness of the procedure at the time of discharge and at follow-up was 100% and 97.5%, respectively. There was no significant difference between groups with regard to any analyzed parameter. CONCLUSION: This study demonstrates that preserving the T2 ganglion is safe, and does not compromise the effectiveness of the procedure. Sympathicotomy has the same success rate as sympathectomy, but requires significantly less dissection and results in less tissue @entity1 .

title: Preserving T2 in thoracic sympathicotomy for @entity2 : less tissue XXXX , same effectiveness.

answer: @entity1


abstract: BACKGROUND: Hybrid video-assisted thoracic surgery (hybrid VATS), combining television monitoring and direct visualization through mini-thoracotomy, has been established as a secure and minimally invasive operation for @entity1 . This study aimed to determine @entity3 levels after hybrid VATS in which intraoperative internal intercostal nerve block is performed. We also examined whether additional use of postoperative continuous infusion of @entity6 improves @entity3 control. METHODS: Data from 131 @entity0 undergoing hybrid VATS were retrospectively analyzed. Thoracoscopic, internal intercostal nerve block was performed at the end of the procedure. @entity3 levels after hybrid VATS, and the impact of postoperative continuous infusion of @entity6 on @entity3 levels and the incidence of @entity4 ( @entity4 ) were examined. RESULTS: 46.6% of @entity0 experienced severe @entity3 (numerical rating scale 7-10) after hybrid VATS. Postoperative continuous infusion of @entity6 was not associated with reduction in @entity3 score, but was independently associated with @entity4 [odds ratio 3.44 (1.52-8.20); P = 0.0027]. CONCLUSIONS: Intraoperative internal intercostal nerve block did not provide sufficient @entity5 after hybrid VATS. Additional use of postoperative continuous infusion of @entity6 did not reduce @entity2 score, but increased the incidence of @entity4 .

title: [Postoperative XXXX after Hybrid Video-assisted Thoracic Surgery].

answer: @entity2


abstract: BACKGROUND: Wound dehiscence complicated by gastrointestinal (GI) @entity1 to belong ,, @entity3 ". Therapy is prolonged and connected with high morbidity and mortality rate. METHODS: In the period from October 2006 to July 2009 we performed 12 reconstructive surgical procedures on gastrointestinal tract in @entity0 with @entity3 . Treatment of 12 consecutive @entity0 (9 @entity0 , 3 @entity0 ) was managed according to a standardize protocol. The protocol consists of treatment of septic complications, optimisation of nutritional state, special wound procedures, diagnosis of @entity2 and GI tract, timing of surgical procedures, reconstruction of GI tract and postoperative care. RESULTS: Reconstructive surgery of GI tract was successful on 11 @entity0 . One @entity0 developed recurrence of @entity2 . In four @entity0 we let open abdomen to heal per secundam. We observed no deaths after operation. CONCLUSION: With regard to complex character of therapy of @entity3 there is a need of multidisciplinary approach. Considering long-lasting and expensive therapy there is logical step to concentrate these @entity0 into special centres which are experienced, equipped and their staff is trained in treatment of such a seriously impaired @entity0 .

title: [Abdominal catastrophe--abdominal wall defect associated with XXXX --strategy of therapy].

answer: @entity2


abstract: INTRODUCTION: Perceptual evaluation is considered the gold standard to evaluate speech nasality. Several procedures are used to collect and analyze perceptual data, which makes it susceptible to errors. Therefore, there has been an increasing desire to find methods that can improve the assessment. OBJECTIVE: To describe and compare the results of speech nasality obtained by assessments of live speech, the Test of @entity1 (THYPER), assessments of audio recorded speech, and nasometry. METHODS: A retrospective study consisting of 331 @entity0 with operated @entity2 . Speech nasality was assessed by four methods of assessment: live perceptual judgement, THYPER, audio-recorded speech sample judgement by multiple judges, and nasometry. All data were collected from medical records of @entity0 , with the exception of the speech sample recording assessment, which was carried out by multiple judges. RESULTS: The results showed that the highest percentages of absence of @entity1 were obtained from judgements performed live and from the THYPER, with equal results between them (79%). Lower percentages were obtained from the recordings by judges (66%) and from nasometry (57%). CONCLUSION: The best results among the four speech nasality evaluation methods were obtained for the ones performed live (live nasality judgement by a speech pathologist and THYPER).

title: Speech nasality and nasometry in XXXX .

answer: @entity2


abstract: Isovolumetrically contracting left ventricle of the anesthetized @entity1 was used to evaluate the end-diastolic pressure-volume relationship [LVEDP (P)-LVEDV (V) relationship (curve)] following changes in heart rate, @entity0 and administration of beta-adrenergic blocking drug. At the same time, relaxation indices were also obtained. Initial left ventricular volume was set at the end-diastolic pressure of 2.0 mmHg. Comparison of each parameters after intervention was done when each initial left ventricular volume was increased by 10 ml. With increase in heart rate, LVEDP increased significantly from 5.1 +/- 2.1 to 14.0 +/- 2.2 mmHg (at 160 bpm, p less than 0.02, vs 100 bpm) and to 24.0 +/- 1.0 mmHg (at 180 bpm, vs p less than 0.001, vs 100 bpm). Regional @entity0 also increased LVEDP significantly from 6.4 +/- 1.4 mmHg to 12.8 +/- 4.1 mmHg (after 30 min, p less than 0.01, vs control) and to 14.1 +/- 4.7 mmHg (after 45 min, p less than 0.01, vs control). However, global @entity0 produced by decreasing coronary perfusion pressure to 50 mmHg, or administration of @entity3 (1.0 mg/kg) brought about no significant changes in LVEDP. Among the relaxation indices, peak negative dp/dt decreased significantly following global @entity0 , regional @entity0 and administration of @entity3 (from 1101 +/- 131 to 733 +/- 49 mmHg/sec, p less than 0.01, from 888 +/- 425 to 268 +/- 94 mmHg/sec after 45 min, p less than 0.01 and from 562 +/- 160 to 291 +/- 100 mmHg/sec, p less than 0.01, respectively). On the other hand, time constant (T) of the left ventricular pressure fall was prolonged significantly following regional @entity0 from 44.7 +/- 5.2 to 72.0 +/- 8.6 msec (after 30 min, p less than 0.001) and 95.4 +/- 26.0 msec (after 30 min, p less than 0.001) and 95.4 +/- 26.0 msec (after 45 min, p less than 0.001). Therefore, it is concluded that LV diastolic compliance decreases by @entity2 (160 and 180 bpm) and regional @entity0 , while the changes of the relaxation indices were not necessarily parallel to those of the LV compliance.

title: [The diastolic pressure-volume relationship of the left ventricle--evaluation of XXXX isovolumetric contracting left ventricle].

answer: @entity1


abstract: UNASSIGNED: Bed rest, a ground-based spaceflight analog, induces robust @entity1 of skeletal muscle, an effect that is exacerbated with increasing age. We examined the effect of 14 days of bed rest on skeletal muscle satellite cell content and fiber @entity1 in middle-aged adults, an understudied age demographic with few overt signs of muscle aging that is representative of astronauts who perform long-duration spaceflight. Muscle biopsies were obtained from the vastus lateralis of healthy middle-aged adults (n=7 [4M;3F]; age: 51  1 y) before (Pre-BR) and after (Post-BR) 14 days of bed rest. Immunohistochemical analyses were used to quantify @entity2 ( @entity2 ) isoform expression, cross-sectional area (CSA), satellite cell and myonuclear content, and capillary density. Peak @entity0 consumption, knee extensor strength, and body composition were also measured Pre- and Post-BR. Post-BR @entity2 Type 2a fiber percentage was reduced and mean CSA decreased in all fiber types (-24  5%; P<0.05). Satellite cell content was also reduced Post-BR (-39  9%; P<0.05) and the change in satellite cell content was significantly correlated with the change in mean fiber CSA (R2=0.60; P<0.05). A decline in capillary density was observed Post-BR (-23  6%; P<0.05), and Post-BR capillary content was significantly associated with Post-BR peak aerobic capacity (R2=0.59; P<0.05). A subtle decline in myonuclear content occurred during bed rest (-5  1%; P<0.05). The rapid maladaptation of skeletal muscle to 14 days of mechanical unloading in middle-aged adults emphasizes the need for robust countermeasures to preserve muscle function in astronauts.

title: 14 days of bed rest induces a decline in satellite cell content and robust XXXX of skeletal muscle fibers in middle-aged adults.

answer: @entity1


abstract: OBJECTIVE: To compare the hematopoietic support provided by telomerized @entity0 mesenchymal stem cells (MSCs) and telomerized MSC-derived stromal cells. METHODS: We transfected the @entity0 @entity2 (hTERT) gene into primary MSCs to establish hTERT-transduced MSCs (hTERT-MSCs). Stromal induction of hTERT-MSCs was performed by replacing the culture medium with Dexter-type culture medium. @entity1 support was examined by coculture with cord blood @entity3 (+) cells. RESULTS: The hTERT-MSCs were morphologically identical with the primary MSCs and expressed surface antigens including CD105, @entity5 , and @entity4 . hTERT-MSCs showed a similar doubling time as primary MSCs and continued to proliferate to over 80 @entity6 ( @entity6 ), although the primary MSCs underwent crisis in vitro at 16 @entity6 . The osteogenic, chondrogenic, adipogenic, neurogenic, and stromal differentiation potential of hTERT-MSCs were maintained up to at least 40 @entity6 . The degree of expansion of @entity3 (+) cells and total number of colony-forming units in culture (CFU-C) upon 12-day coculture with the hTERT-MSC-derived stromal cells were nearly the same as those upon 12-day coculture with hTERT-MSCs ( @entity3 , 33.0-fold+/-2.8-fold vs 36.1-fold+/-1.7-fold of the initial cell number; CFUs, 344.4-fold+/-62.5-fold vs 239.3-fold+/-87.0-fold; CFU-mix, 368.4-fold+/-113.7-fold vs 341.3-fold+/-234.3-fold). However, on day 18 of coculture, the number of cobblestone areas (CA) observed beneath the stromal cells was 15 times higher than that beneath hTERT-MSCs (CA, 146.9+/-54.6 vs 9.4+/-8.1, p<0.01). CONCLUSION: Stromal induction of hTERT-MSCs exclusively enhanced the support of CA formation provided by hTERT-MSCs. Our @entity0 hTERT-MSCs will be useful for elucidating the mechanism of the formation of CAs.

title: Telomerized XXXX multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells.

answer: @entity0


abstract: UNASSIGNED: The presence of @entity2 in advanced @entity2 @entity0 is associated with both a poor prognosis and quality of life with a risk of @entity5 and @entity4 . Contemporary noninvasive visualization methods such as ultrasound, computed tomography, and magnetic resonance imaging (MRI) often struggle to differentiate @entity2 from surrounding tissues. This study aimed to determine the utility of selective @entity8 imaging in the abdominal cavity with a free radical probe and @entity9 ( @entity6 ) contrast agent using in vivo dynamic nuclear polarization-MRI (DNP-MRI). Phantom imaging experiments established a linear relationship between @entity8 volume and image intensity using in vivo DNP-MRI. Similar results were obtained when the radical-D2O probe was used to determine selective and spatial information on @entity8 in vivo, modeled by the injection of saline into the abdominal cavity of @entity3 . To demonstrate the utility of this method for disease, @entity2 in peritoneal @entity1 animal model was selected as one of the typical examples. In vivo DNP-MRI of peritoneal @entity1 animal model was performed 7-21 days after intraperitoneal injection of luciferase, stably expressing the @entity0 @entity7 (SUIT-2). The image intensity with increasing @entity2 was significantly increased at days 7, 16, and 21. This increase corresponded to in vivo @entity2 progression, as measured by bioluminescent imaging. These results suggest that @entity8 signal enhancement in DNP-MRI using radical-D2O contrast is positively associated with the progression of dissemination and could be a useful biomarker for @entity2 with @entity2 @entity1 .

title: Selective Imaging of Malignant Ascites in a @entity3 Model of Peritoneal XXXX Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.

answer: @entity1


abstract: UNASSIGNED: The presence of @entity2 in advanced @entity2 @entity0 is associated with both a poor prognosis and quality of life with a risk of @entity5 and @entity4 . Contemporary noninvasive visualization methods such as ultrasound, computed tomography, and magnetic resonance imaging (MRI) often struggle to differentiate @entity2 from surrounding tissues. This study aimed to determine the utility of selective @entity8 imaging in the abdominal cavity with a free radical probe and @entity9 ( @entity6 ) contrast agent using in vivo dynamic nuclear polarization-MRI (DNP-MRI). Phantom imaging experiments established a linear relationship between @entity8 volume and image intensity using in vivo DNP-MRI. Similar results were obtained when the radical-D2O probe was used to determine selective and spatial information on @entity8 in vivo, modeled by the injection of saline into the abdominal cavity of @entity3 . To demonstrate the utility of this method for disease, @entity2 in peritoneal @entity1 animal model was selected as one of the typical examples. In vivo DNP-MRI of peritoneal @entity1 animal model was performed 7-21 days after intraperitoneal injection of luciferase, stably expressing the @entity0 @entity7 (SUIT-2). The image intensity with increasing @entity2 was significantly increased at days 7, 16, and 21. This increase corresponded to in vivo @entity2 progression, as measured by bioluminescent imaging. These results suggest that @entity8 signal enhancement in DNP-MRI using radical-D2O contrast is positively associated with the progression of dissemination and could be a useful biomarker for @entity2 with @entity2 @entity1 .

title: Selective Imaging of Malignant Ascites in a XXXX Model of Peritoneal @entity1 Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.

answer: @entity3


abstract: AIMS: We evaluated if killer cell immunoglobulin-like receptor 3DL2 gene ( @entity2 ) polymorphisms are a key factor in the development of @entity1 . METHODS: In this case-control study, 105 pregnant @entity0 with PE (PE group) were enrolled. Their @entity3 in exon 3 and @entity4 in exon 9 polymorphisms of the @entity2 genotypes were determined by polymorphism chain reaction-restriction fragment length polymorphism (PCR-RFLP) from venous blood samples and compared with the corresponding @entity2 genotypes of 103 pregnant @entity0 with uncomplicated pregnancies (control group). RESULTS: Carriers of the A allele in exon 3 of @entity2 gene occurred less frequently in PE than in controls [P=0.001; odds ratio (OR)=2.65, range: 1.5-4.7]. No significant difference was found about allelic frequencies of @entity2 gene @entity4 in exon 9 in @entity0 with @entity1 as compared to controls. A significant difference between the two groups of genotypic frequencies of @entity2 gene @entity3 in exon 3 and @entity2 gene @entity4 in exon 9 polymorphisms was found (P=0.003 and P=0.000). There was no significant difference between genotypic or allelic frequencies in @entity0 with mild @entity1 compared to sever @entity1 . CONCLUSIONS: Our results suggest that carriers of A allele in exon 3 have a decreased susceptibility to PE. It is likely that the presence of the CC genotype in exon 9 has a considerable effect on disease progression. The mutation of the two sites is not associated with the severity of @entity1 .

title: Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in XXXX .

answer: @entity1


abstract: Thirty-two @entity0 treated for @entity2 were retrospectively reviewed. The results of treatment were assessed by clinical and radiographic parameters and arbitrarily classified good, fair, or poor. Five @entity0 were definitively treated with braces; five extremities were rated good and one poor. Twelve @entity0 were treated with a proximal tibial osteotomy performed before their fifth birthday. Nineteen extremities were rated good, one fair, and three poor. Fifteen @entity0 had their initial surgical procedure after the fifth birthday. Eight extremities were rated good, six fair, and seven poor. Recurrence of the @entity1 secondary to an unsuspected medial bony physeal bar occurred in four @entity0 . Resection of this bony bridge concomitant with a varus correcting osteotomy may be indicated. For severe @entity1 in older @entity0 , several different salvage procedures were used.

title: XXXX : a retrospective review and recommendations for treatment.

answer: @entity2


abstract: The detection of either impairment of coronary flow reserve at rest or abnormalities of regional myocardial function during an @entity0 stress are both means of defining the physiologic significance of @entity4 . The relation between these two indexes has not been defined previously, particularly in the setting of mild @entity1 of coronary flow reserve. Therefore, this relation was investigated in nine open chest anesthetized @entity2 . Graded, subcritical @entity4 were produced that impaired postocclusion hyperemic flow, but not coronary blood flow at rest. Subendocardial ultrasonic crystals were used to measure segment length shortening at rest and after maximal atrial pacing. There was a curvilinear relation between pacing-induced deterioration of segment length shortening and @entity1 at rest with the most substantial decrease in regional function occurring when less than 20 to 40% of control reactive @entity3 remained. This corresponded to a reactive hyperemic ratio between 1.7 and 2.3. This nonlinear relation was paralleled by the relation between deterioration of regional function and the percent of control blood flow recorded at the time of regional postpacing dysfunction in the presence of @entity4 . It is concluded that coronary flow reserve may be substantially reduced before regional dysfunction induced by atrial pacing becomes pronounced. The extent of regional dysfunction during atrial pacing is, in large part, due to the alterations in coronary blood flow occurring during this form of stress in the presence of @entity4 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Relation between graded, XXXX of coronary flow reserve and regional myocardial dysfunction induced by atrial pacing in @entity2 .

answer: @entity1


abstract: The detection of either impairment of coronary flow reserve at rest or abnormalities of regional myocardial function during an @entity0 stress are both means of defining the physiologic significance of @entity4 . The relation between these two indexes has not been defined previously, particularly in the setting of mild @entity1 of coronary flow reserve. Therefore, this relation was investigated in nine open chest anesthetized @entity2 . Graded, subcritical @entity4 were produced that impaired postocclusion hyperemic flow, but not coronary blood flow at rest. Subendocardial ultrasonic crystals were used to measure segment length shortening at rest and after maximal atrial pacing. There was a curvilinear relation between pacing-induced deterioration of segment length shortening and @entity1 at rest with the most substantial decrease in regional function occurring when less than 20 to 40% of control reactive @entity3 remained. This corresponded to a reactive hyperemic ratio between 1.7 and 2.3. This nonlinear relation was paralleled by the relation between deterioration of regional function and the percent of control blood flow recorded at the time of regional postpacing dysfunction in the presence of @entity4 . It is concluded that coronary flow reserve may be substantially reduced before regional dysfunction induced by atrial pacing becomes pronounced. The extent of regional dysfunction during atrial pacing is, in large part, due to the alterations in coronary blood flow occurring during this form of stress in the presence of @entity4 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Relation between graded, @entity1 of coronary flow reserve and regional myocardial dysfunction induced by atrial pacing in XXXX .

answer: @entity2


abstract: BACKGROUND: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on @entity1 , @entity3 ( @entity3 ) and all-cause mortality, and most included @entity6 avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. METHODS: In 1992 and 1993, 111,966 nonsmoking @entity0 and @entity0 in the @entity1 Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American @entity1 Society @entity1 prevention guidelines on body mass index, physical activity, diet, and @entity4 consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of @entity5 and 95% CI were computed by Cox proportional hazard regression. RESULTS: During 14 years of follow-up, 10,369 @entity0 and 6,613 @entity0 died. The RR of all-cause mortality was lower for @entity0 with high (7, 8) versus low (0-2) scores ( @entity0 , RR = 0.58, 95% CI: 0.53-0.62; @entity0 , RR = 0.58, 95% CI: 0.52-0.64). Inverse associations were found with @entity3 mortality ( @entity0 , RR = 0.52, 95% CI: 0.45-0.59; @entity0 , RR = 0.42, 95% CI: 0.35-0.51) and @entity1 mortality ( @entity0 , RR = 0.70, 95% CI: 0.61-0.80; @entity0 , RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. CONCLUSION: Adherence to @entity1 prevention guidelines for @entity2 , diet, physical activity, and @entity4 consumption is associated with lower risk of @entity5 from @entity1 , @entity3 , and all causes in nonsmokers. IMPACT: Beyond @entity6 avoidance, following other @entity1 prevention guidelines may substantially lower risk of premature mortality in older adults.

title: Following @entity1 prevention guidelines reduces risk of @entity1 , XXXX , and all-cause mortality.

answer: @entity3


abstract: BACKGROUND: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on @entity1 , @entity3 ( @entity3 ) and all-cause mortality, and most included @entity6 avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. METHODS: In 1992 and 1993, 111,966 nonsmoking @entity0 and @entity0 in the @entity1 Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American @entity1 Society @entity1 prevention guidelines on body mass index, physical activity, diet, and @entity4 consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of @entity5 and 95% CI were computed by Cox proportional hazard regression. RESULTS: During 14 years of follow-up, 10,369 @entity0 and 6,613 @entity0 died. The RR of all-cause mortality was lower for @entity0 with high (7, 8) versus low (0-2) scores ( @entity0 , RR = 0.58, 95% CI: 0.53-0.62; @entity0 , RR = 0.58, 95% CI: 0.52-0.64). Inverse associations were found with @entity3 mortality ( @entity0 , RR = 0.52, 95% CI: 0.45-0.59; @entity0 , RR = 0.42, 95% CI: 0.35-0.51) and @entity1 mortality ( @entity0 , RR = 0.70, 95% CI: 0.61-0.80; @entity0 , RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. CONCLUSION: Adherence to @entity1 prevention guidelines for @entity2 , diet, physical activity, and @entity4 consumption is associated with lower risk of @entity5 from @entity1 , @entity3 , and all causes in nonsmokers. IMPACT: Beyond @entity6 avoidance, following other @entity1 prevention guidelines may substantially lower risk of premature mortality in older adults.

title: Following XXXX prevention guidelines reduces risk of @entity1 , @entity3 , and all-cause mortality.

answer: @entity1


abstract: BACKGROUND: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on @entity1 , @entity3 ( @entity3 ) and all-cause mortality, and most included @entity6 avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. METHODS: In 1992 and 1993, 111,966 nonsmoking @entity0 and @entity0 in the @entity1 Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American @entity1 Society @entity1 prevention guidelines on body mass index, physical activity, diet, and @entity4 consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of @entity5 and 95% CI were computed by Cox proportional hazard regression. RESULTS: During 14 years of follow-up, 10,369 @entity0 and 6,613 @entity0 died. The RR of all-cause mortality was lower for @entity0 with high (7, 8) versus low (0-2) scores ( @entity0 , RR = 0.58, 95% CI: 0.53-0.62; @entity0 , RR = 0.58, 95% CI: 0.52-0.64). Inverse associations were found with @entity3 mortality ( @entity0 , RR = 0.52, 95% CI: 0.45-0.59; @entity0 , RR = 0.42, 95% CI: 0.35-0.51) and @entity1 mortality ( @entity0 , RR = 0.70, 95% CI: 0.61-0.80; @entity0 , RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. CONCLUSION: Adherence to @entity1 prevention guidelines for @entity2 , diet, physical activity, and @entity4 consumption is associated with lower risk of @entity5 from @entity1 , @entity3 , and all causes in nonsmokers. IMPACT: Beyond @entity6 avoidance, following other @entity1 prevention guidelines may substantially lower risk of premature mortality in older adults.

title: Following @entity1 prevention guidelines reduces risk of XXXX , @entity3 , and all-cause mortality.

answer: @entity1


abstract: The ultraviolet (UV) region of solar radiation is a critical factor in the initiation and development of a number of @entity2 . However, it is not only skin which is directly exposed to solar light that is affected by UV radiation, through low molecular weight mediators, generated upon irradiation, "non-skin" tissues can also be affected. The aim of this study was to examine in detail, the acute effects of UVA and UVB wavebands on hairless @entity0 . Female SKH-1 hairless @entity0 were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)) using a solar simulator. The effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of @entity4 ( @entity6 ), markers of oxidative damage (lipid peroxidation and carbonylated proteins) were analysed in erythrocytes, plasma, liver and whole skin homogenates. No macroscopic changes were observed either 4 or 24 h after UVA/UVB exposure. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h following UVA and UVB irradiation, which disappeared 24 h after irradiation except for the higher UVA dose. Changes in oxidative stress-related parameters, particularly activity of catalase (CAT) and @entity1 dismutase (SOD) and level of @entity6 and lipid peroxidation products, were found in skin, erythrocytes and liver. The expression of several enzymes (CAT, SOD, @entity4 transferase (GST), @entity5 ( @entity3 ) @entity7 oxidoreductase ( @entity8 ) and hem oxygenase-1 (HO-1)) in skin was affected following UVA and UVB radiation. Increase in carbonylated proteins was found in plasma and skin samples.

title: Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless XXXX .

answer: @entity0


abstract: BACKGROUND: The side-effects of anti-retroviral drugs are different between Japanese and Caucasian @entity0 . Severe central nerve system (CNS) side-effects to efavirenz and low rate of @entity1 against @entity10 characterize the Japanese. OBJECTIVE: The objective of this study was to select a once daily regimen for further non-inferior study comparing the virological efficacy and safety of the first line once daily antiretroviral treatment regimens in the current @entity5 / @entity6 guideline. METHODS: The study design was a randomized, open label, multicenter, selection study. One arm was treated with efavirenz and the other with @entity4 -boosted @entity7 . A fixed-dose @entity9 plus @entity10 were used in both arms. The primary endpoint was virologic success (viral load less than 50 copies/mL) rate at 48 weeks. @entity0 were followed-up to 96 weeks with safety as the secondary endpoint. Clinicaltrials. @entity11 (NCT00280969) and the University hospital Medical Information Network (UMIN000000243). RESULTS: A total of 71 @entity0 were enrolled. Virologic success rates in both arms were similar at week 48 [efavirenz arm 28/36 (77.8%); @entity7 arm 27/35 (77.1%)], but were decreased at week 96 to 55.6% in the efavirenz arm and 68.8% in the @entity7 arm (p=0.33). At the 96-week follow-up, 52.8% of the EFV arm and 34.3% of the @entity8 /r arm reached total @entity3 more than 220 mg/dL and required treatment. None of the @entity0 developed @entity2 in this study by week 96. CONCLUSION: There was no significant difference in the efficacy of efavirenz and @entity4 -boosted @entity7 combined with @entity9 plus @entity10 at 48 weeks. The evaluation of safety was extended to 96 weeks, which also showed no significant difference in both arms.

title: Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen comparing @entity4 -boosted @entity7 to efavirenz with fixed-dose XXXX and @entity9 .

answer: @entity10


abstract: BACKGROUND: The side-effects of anti-retroviral drugs are different between Japanese and Caucasian @entity0 . Severe central nerve system (CNS) side-effects to efavirenz and low rate of @entity1 against @entity10 characterize the Japanese. OBJECTIVE: The objective of this study was to select a once daily regimen for further non-inferior study comparing the virological efficacy and safety of the first line once daily antiretroviral treatment regimens in the current @entity5 / @entity6 guideline. METHODS: The study design was a randomized, open label, multicenter, selection study. One arm was treated with efavirenz and the other with @entity4 -boosted @entity7 . A fixed-dose @entity9 plus @entity10 were used in both arms. The primary endpoint was virologic success (viral load less than 50 copies/mL) rate at 48 weeks. @entity0 were followed-up to 96 weeks with safety as the secondary endpoint. Clinicaltrials. @entity11 (NCT00280969) and the University hospital Medical Information Network (UMIN000000243). RESULTS: A total of 71 @entity0 were enrolled. Virologic success rates in both arms were similar at week 48 [efavirenz arm 28/36 (77.8%); @entity7 arm 27/35 (77.1%)], but were decreased at week 96 to 55.6% in the efavirenz arm and 68.8% in the @entity7 arm (p=0.33). At the 96-week follow-up, 52.8% of the EFV arm and 34.3% of the @entity8 /r arm reached total @entity3 more than 220 mg/dL and required treatment. None of the @entity0 developed @entity2 in this study by week 96. CONCLUSION: There was no significant difference in the efficacy of efavirenz and @entity4 -boosted @entity7 combined with @entity9 plus @entity10 at 48 weeks. The evaluation of safety was extended to 96 weeks, which also showed no significant difference in both arms.

title: Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen comparing XXXX -boosted @entity7 to efavirenz with fixed-dose @entity10 and @entity9 .

answer: @entity4


abstract: BACKGROUND: The side-effects of anti-retroviral drugs are different between Japanese and Caucasian @entity0 . Severe central nerve system (CNS) side-effects to efavirenz and low rate of @entity1 against @entity10 characterize the Japanese. OBJECTIVE: The objective of this study was to select a once daily regimen for further non-inferior study comparing the virological efficacy and safety of the first line once daily antiretroviral treatment regimens in the current @entity5 / @entity6 guideline. METHODS: The study design was a randomized, open label, multicenter, selection study. One arm was treated with efavirenz and the other with @entity4 -boosted @entity7 . A fixed-dose @entity9 plus @entity10 were used in both arms. The primary endpoint was virologic success (viral load less than 50 copies/mL) rate at 48 weeks. @entity0 were followed-up to 96 weeks with safety as the secondary endpoint. Clinicaltrials. @entity11 (NCT00280969) and the University hospital Medical Information Network (UMIN000000243). RESULTS: A total of 71 @entity0 were enrolled. Virologic success rates in both arms were similar at week 48 [efavirenz arm 28/36 (77.8%); @entity7 arm 27/35 (77.1%)], but were decreased at week 96 to 55.6% in the efavirenz arm and 68.8% in the @entity7 arm (p=0.33). At the 96-week follow-up, 52.8% of the EFV arm and 34.3% of the @entity8 /r arm reached total @entity3 more than 220 mg/dL and required treatment. None of the @entity0 developed @entity2 in this study by week 96. CONCLUSION: There was no significant difference in the efficacy of efavirenz and @entity4 -boosted @entity7 combined with @entity9 plus @entity10 at 48 weeks. The evaluation of safety was extended to 96 weeks, which also showed no significant difference in both arms.

title: Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen comparing @entity4 -boosted XXXX to efavirenz with fixed-dose @entity10 and @entity9 .

answer: @entity7


abstract: BACKGROUND: The side-effects of anti-retroviral drugs are different between Japanese and Caucasian @entity0 . Severe central nerve system (CNS) side-effects to efavirenz and low rate of @entity1 against @entity10 characterize the Japanese. OBJECTIVE: The objective of this study was to select a once daily regimen for further non-inferior study comparing the virological efficacy and safety of the first line once daily antiretroviral treatment regimens in the current @entity5 / @entity6 guideline. METHODS: The study design was a randomized, open label, multicenter, selection study. One arm was treated with efavirenz and the other with @entity4 -boosted @entity7 . A fixed-dose @entity9 plus @entity10 were used in both arms. The primary endpoint was virologic success (viral load less than 50 copies/mL) rate at 48 weeks. @entity0 were followed-up to 96 weeks with safety as the secondary endpoint. Clinicaltrials. @entity11 (NCT00280969) and the University hospital Medical Information Network (UMIN000000243). RESULTS: A total of 71 @entity0 were enrolled. Virologic success rates in both arms were similar at week 48 [efavirenz arm 28/36 (77.8%); @entity7 arm 27/35 (77.1%)], but were decreased at week 96 to 55.6% in the efavirenz arm and 68.8% in the @entity7 arm (p=0.33). At the 96-week follow-up, 52.8% of the EFV arm and 34.3% of the @entity8 /r arm reached total @entity3 more than 220 mg/dL and required treatment. None of the @entity0 developed @entity2 in this study by week 96. CONCLUSION: There was no significant difference in the efficacy of efavirenz and @entity4 -boosted @entity7 combined with @entity9 plus @entity10 at 48 weeks. The evaluation of safety was extended to 96 weeks, which also showed no significant difference in both arms.

title: Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen comparing @entity4 -boosted @entity7 to efavirenz with fixed-dose @entity10 and XXXX .

answer: @entity9


abstract: BACKGROUND: Dual chamber pacing improves functional status and reduces left ventricular outflow tract gradients in some, but not all @entity0 with @entity2 ( @entity2 ) by altering ventricular depolarisation. We investigated the use of biventricular ( @entity3 ) pacing in symptomatic @entity0 with @entity2 . METHOD: 8 @entity0 aged 58  7yrs with symptomatic @entity2 underwent @entity3 pacing. 5 @entity0 had LVOT gradients >30mmHg. Ventricular electrodes were placed in the right ventricle (RV) and a branch of the coronary sinus. An atrial electrode was inserted to achieve @entity3 pacing with a short AV delay. The short-term effects of different pacing modalities were assessed using 2-D and Doppler echocardiography. Symptoms and exercise tolerance were assessed after a month of each pacing mode. Long-term follow up data was available for 5 years. RESULTS: Baseline EF was 67  14% and mean QRS duration was 132  26msecs. @entity3 pacing reduced QRS duration compared to RV pacing (129  46 vs. 205  54msecs, p<0.005). Five of the seven @entity0 had baseline LVOT gradients (mean 67  25mmHg) that decreased to 41  15mm Hg with RV pacing (p<0.01) and 25  15mmHg with @entity3 pacing (p<0.005). Improvements in exercise time with active pacing occurred in six out of eight @entity0 (75%), three (37.5%) had optimal exercise times with RV pacing and three with @entity3 pacing. Of the three @entity0 with short term improvements with @entity3 pacing, one died 4 years post implant, one deteriorated with LV dilatation and one had the system explanted for @entity1 . CONCLUSION: @entity3 pacing showed short-term beneficial effects in some @entity0 over and above RV pacing alone.

title: Initial experience of a cohort of @entity0 with XXXX undergoing biventricular pacing.

answer: @entity2


abstract: BACKGROUND: Dual chamber pacing improves functional status and reduces left ventricular outflow tract gradients in some, but not all @entity0 with @entity2 ( @entity2 ) by altering ventricular depolarisation. We investigated the use of biventricular ( @entity3 ) pacing in symptomatic @entity0 with @entity2 . METHOD: 8 @entity0 aged 58  7yrs with symptomatic @entity2 underwent @entity3 pacing. 5 @entity0 had LVOT gradients >30mmHg. Ventricular electrodes were placed in the right ventricle (RV) and a branch of the coronary sinus. An atrial electrode was inserted to achieve @entity3 pacing with a short AV delay. The short-term effects of different pacing modalities were assessed using 2-D and Doppler echocardiography. Symptoms and exercise tolerance were assessed after a month of each pacing mode. Long-term follow up data was available for 5 years. RESULTS: Baseline EF was 67  14% and mean QRS duration was 132  26msecs. @entity3 pacing reduced QRS duration compared to RV pacing (129  46 vs. 205  54msecs, p<0.005). Five of the seven @entity0 had baseline LVOT gradients (mean 67  25mmHg) that decreased to 41  15mm Hg with RV pacing (p<0.01) and 25  15mmHg with @entity3 pacing (p<0.005). Improvements in exercise time with active pacing occurred in six out of eight @entity0 (75%), three (37.5%) had optimal exercise times with RV pacing and three with @entity3 pacing. Of the three @entity0 with short term improvements with @entity3 pacing, one died 4 years post implant, one deteriorated with LV dilatation and one had the system explanted for @entity1 . CONCLUSION: @entity3 pacing showed short-term beneficial effects in some @entity0 over and above RV pacing alone.

title: Initial experience of a cohort of XXXX with @entity2 undergoing biventricular pacing.

answer: @entity0


abstract: Although the metal devices used in orthodontic treatments are manufactured highly resistance to corrosion, they may still suffer some localized corrosion resulting from the oral cavity conditions. The corrosion causes the release of metals from the alloys used for their manufacture. In this report, we evaluated the in vivo metal ions release of three alloys (stainless steel, @entity3 and @entity6 -free) usually used in the orthodontics treatments and its genotoxicity. We applied to 15 @entity0 , between 12 and 16 years, 4 tubes and 20 brackets. Samples from oral mucosa were taken before the treatment and 30 days later. The concentration of the @entity3 , @entity7 , @entity4 , @entity5 , @entity6 , @entity8 and @entity2 were detected using inductively coupled plasma mass spectrometry (ICP- @entity1 ). The genotoxicity was measured with a comet assay (Olive moment). The oral mucosa cells in contact with the stainless steel alloy displayed the greatest @entity3 and @entity4 concentrations and those in contact with the @entity6 -free alloy presented the greatest concentration of @entity7 and @entity2 . Both alloys, stainless steel and @entity6 -free, induced a higher DNA damage in the oral mucosa cells than the @entity3 alloy, in which the Olive moment was similar to controls. Based on the results of our study, we can conclude that @entity3 brackets and tubes are the most biocompatible of the three alloys.

title: Metallic ion content and damage to the DNA in oral mucosa cells of XXXX with fixed orthodontic appliances.

answer: @entity0


abstract: The optimal method of transecting liver parenchyma has not been established and presently a variety of methods are in use. In a controlled study in @entity3 standard resections were performed with four different transection techniques: ultrasonic dissection, suction dissection, electrocautery, and sharp dissection. The @entity1 , number of vessels identified before their division, need for additional hemostatic measures, and time for each procedure were evaluated. Also, the histologic appearance of the fresh and the healing cut surface of the liver was studied. The @entity1 was the lowest when ultrasonic dissection was used (median @entity1 of 58 ml per resection). The comparisons with suction dissection (median @entity1 of 87 ml) and cautery (median @entity1 of 79 ml) were not significant. The ultrasonic and suction dissection techniques were both effective in isolating vessels, but the ultrasonic dissector did this more atraumatically. Cautery and ultrasonic dissection had a hemostatic effect on the parenchyma in that a significantly smaller number of vessels needed to be clipped or tied. On histologic study of the fresh cut liver surface, a smooth surface was seen with ultrasonic dissection, @entity2 after suction dissection, and coagulation @entity0 after electrocautery. Ultrasonic dissection was the only technique that combined lowered @entity1 because medium- and large-size vessels were dissected free and ligated before transection and a hemostatic effect on small vessels.

title: Liver transection: a controlled study of four different techniques in XXXX .

answer: @entity3


abstract: A total of 52 @entity4 @entity0 was treated with @entity3 at three dose levels: 21 @entity0 received 3 x 25.0 mg/kg bwt on a single day, 21 @entity0 were treated with 3 x 25.0 mg/kg for 2 consecutive days and 10 @entity0 were treated with the same dose for 3 consecutive days. Follow-up examination were carried out at monthly up to 4 months (120 days) after treatment. Fifteen (71.4%) out of 21 @entity0 who received the drug 3 x 25.0 mg/kg bwt on a single day were parasitologically cured. Eighteen (85.7%) out of 21 @entity0 who received 3 x 25.0 mg/kg bwt for 2 consecutive days were also cured. Six and 3 of uncured cases in each above groups were treated again with doses of 3 x 25.0 mg/kg bwt for 2 or 3 consecutive days. Two (consisting each one in each group ) of nine retreated cases were failed in parasitological cure. Therefore the overall cure rates of 95.2 % (20 out of 21 cases) in each group were finally obtained. On the other hand, in 10 @entity0 who received 3 x 25.0 mg/kg bwt for 3 consecutive days, complete cure was obtained at 4 months follow-up examinations. Praziquantel is well tolerated and side effects consist particularly of mild and transient @entity1 and @entity2 . There was no great difference between the three dosage groups. Extended hematological and biochemical tests, and urinalysis, revealed no abnormal findings which could be related to the compound after therapy. The disappearance of precipitating bands of immunoelectrophoresis together with the disappearance of abnormal shawdows in chest X-ray after treatment gave a potent proof on assuring the cure of @entity4 .

title: Clinical Evaluation Of Praziquantel( XXXX ; Biltricide(R)) In The Treatment Of Paragonimus Westermani.

answer: @entity3


abstract: The concentration of @entity1 ( @entity2 ) in serum and bile was estimated after intravenous drip infusion of 1 g of the drug in 11 @entity0 , who have performed cholecystectomy, choledocholithotomy and T-tube drainage for @entity3 . Administration of @entity4 ( @entity5 ) 1 g was compared by the cross over method. After 1 g intravenous drip infusion of @entity2 , the mean serum concentration was 88.3 +/- 24 micrograms/ml at 1 hour, 52 +/- 11.7 micrograms/ml at 2 hours and 36.5 +/- 10 micrograms/ml at 4 hours. The maintenance period of serum concentration was inclined to be longer in @entity2 than in @entity5 . After 1 g intravenous drip infusion of @entity2 , the mean bile concentration reached to 810 +/- 459 micrograms/ml in 2 hours and it was maintained as high as 562 +/- 319 micrograms/ml even after 4 hours. On the other hand, after 1 g intravenous drip infusion of @entity5 , the mean bile concentration was only 28.7 +/- 26 micrograms/ml in 1 hour and was low level in the progress. As compared with the highest concentration of @entity2 and @entity5 in same @entity0 , the mean bile concentration of @entity2 (942 +/- 525 micrograms/ml) was about 30 times higher than that of @entity5 (28.6 +/- 26.3 micrograms/ml). There was no difference in the group of Gram-positive cocci between minimum inhibitory concentration (MIC) of @entity2 and that of @entity5 . While MIC of @entity5 in the group of Gram-negative bacilli was from 0.78 to over 400 micrograms/ml, MIC of @entity2 in that group was from 0.10 to 50 micrograms/ml. The value in @entity2 was lower than that in @entity5 at all strains. No side effects was seen in all @entity0 .

title: [Clinical studies with XXXX in the biliary disease].

answer: @entity1


abstract: The present study was undertaken to observe the pathologic changes of the liver in albino @entity0 with @entity5 . Twenty five @entity0 given 50 metacercariae respectively by mouth were autopsied at 3 days (group 1), one week (group 2), 4 weeks (group 3), 8 weeks (group 4) and 12 weeks (group 5) of @entity3 . The following results were obtained: 1. Parasites were seen in bile ducts of group 2, 3, 4, 5 and increased in number with duration of @entity3 . 2. The pathologic changes in the liver were prominent in intrahepatic bile ducts. Epithelial cells of bile ducts showed definite atypia and proliferation resulting in pseudostratification in group. Stratification of metaplastic squamous cells and glandular proliferation were prominent in group 3. The epithelial cells were keratinized with syncitium and cribriform formation in group 4 and almost suggestive of @entity4 in group 5. 3. Periductal @entity1 seen in group 4 was considerable as well as mature with hyalinized connective tissue in group 5. 4. Heavy inflammatory cell infiltrations around the affected bile ducts in group 1 became smaller in number with duration of @entity3 . The inflammatory cells consisted of the majority of eosinophils in group 1 and chiefly plasma cells, lymphocytes and mononuclear cells in group 5. 5. Veins in portal spaces dilated markedly in group 1 became less prominent with duration of @entity3 . 6. Although portal @entity1 increased definitely in group 3 often extended into the hepatic lobules in group 4, the changes of hepatic cells, sinusoids and central veins were negligible. Above results suggest that @entity6 could be a factor in inducing primary @entity2 in albino @entity0 .

title: [Studies On Pathological Changes Of The Liver In Abino @entity0 Infected With XXXX ]

answer: @entity5


abstract: The present study was undertaken to observe the pathologic changes of the liver in albino @entity0 with @entity5 . Twenty five @entity0 given 50 metacercariae respectively by mouth were autopsied at 3 days (group 1), one week (group 2), 4 weeks (group 3), 8 weeks (group 4) and 12 weeks (group 5) of @entity3 . The following results were obtained: 1. Parasites were seen in bile ducts of group 2, 3, 4, 5 and increased in number with duration of @entity3 . 2. The pathologic changes in the liver were prominent in intrahepatic bile ducts. Epithelial cells of bile ducts showed definite atypia and proliferation resulting in pseudostratification in group. Stratification of metaplastic squamous cells and glandular proliferation were prominent in group 3. The epithelial cells were keratinized with syncitium and cribriform formation in group 4 and almost suggestive of @entity4 in group 5. 3. Periductal @entity1 seen in group 4 was considerable as well as mature with hyalinized connective tissue in group 5. 4. Heavy inflammatory cell infiltrations around the affected bile ducts in group 1 became smaller in number with duration of @entity3 . The inflammatory cells consisted of the majority of eosinophils in group 1 and chiefly plasma cells, lymphocytes and mononuclear cells in group 5. 5. Veins in portal spaces dilated markedly in group 1 became less prominent with duration of @entity3 . 6. Although portal @entity1 increased definitely in group 3 often extended into the hepatic lobules in group 4, the changes of hepatic cells, sinusoids and central veins were negligible. Above results suggest that @entity6 could be a factor in inducing primary @entity2 in albino @entity0 .

title: [Studies On Pathological Changes Of The Liver In Abino XXXX Infected With @entity5 ]

answer: @entity0


abstract: OBJECTIVE: The majority of the @entity2 in periampullary region are @entity7 . The aim of this study was to compare histopathological features of ampulla of @entity3 with @entity5 and to determine diagnostic and predictive values of @entity4 protein and @entity8 expression. MATERIAL AND METHOD: Tissue samples from @entity5 were obtained from 31 @entity0 who underwent pancreticoduodenectomy for @entity3 . The study group was composed of 12 @entity0 and 19 @entity0 . Their median age was found to be 62.32 years (range 26-85 years). The parameters analyzed in the study included lymph node @entity1 , perineural invasion, differentiation, duodenal invasion, grade of @entity9 and @entity4 and @entity8 expression in tumoral and peritumoral pancreatic tissues. RESULTS: In both @entity2 groups, the loss of @entity4 protein expression was significantly correlated with perineural invasion (p = 0.0001). Perineural invasion was more frequent in the @entity5 group than the ampulla of @entity3 group (p = 0.01). When desmoplasia and lymphoplasmacytic stromal infiltration were examined, desmoplastic reaction was significantly higher in @entity5 than ampulla of @entity3 (p = 0.01). No significant difference was observed between @entity2 groups for @entity8 (p > 0.05). CONCLUSION: The results suggest that loss of @entity4 protein expression may be a sign for poor prognosis in @entity2 that is correlated mainly with perineural invasion. @entity6 stromal reaction may be a distinctive feature for @entity5 compared with ampulla of @entity3 .

title: Expression of XXXX protein and @entity8 in periampullary @entity3 .

answer: @entity4


abstract: OBJECTIVE: The majority of the @entity2 in periampullary region are @entity7 . The aim of this study was to compare histopathological features of ampulla of @entity3 with @entity5 and to determine diagnostic and predictive values of @entity4 protein and @entity8 expression. MATERIAL AND METHOD: Tissue samples from @entity5 were obtained from 31 @entity0 who underwent pancreticoduodenectomy for @entity3 . The study group was composed of 12 @entity0 and 19 @entity0 . Their median age was found to be 62.32 years (range 26-85 years). The parameters analyzed in the study included lymph node @entity1 , perineural invasion, differentiation, duodenal invasion, grade of @entity9 and @entity4 and @entity8 expression in tumoral and peritumoral pancreatic tissues. RESULTS: In both @entity2 groups, the loss of @entity4 protein expression was significantly correlated with perineural invasion (p = 0.0001). Perineural invasion was more frequent in the @entity5 group than the ampulla of @entity3 group (p = 0.01). When desmoplasia and lymphoplasmacytic stromal infiltration were examined, desmoplastic reaction was significantly higher in @entity5 than ampulla of @entity3 (p = 0.01). No significant difference was observed between @entity2 groups for @entity8 (p > 0.05). CONCLUSION: The results suggest that loss of @entity4 protein expression may be a sign for poor prognosis in @entity2 that is correlated mainly with perineural invasion. @entity6 stromal reaction may be a distinctive feature for @entity5 compared with ampulla of @entity3 .

title: Expression of @entity4 protein and @entity8 in periampullary XXXX .

answer: @entity3


abstract: OBJECTIVE: The majority of the @entity2 in periampullary region are @entity7 . The aim of this study was to compare histopathological features of ampulla of @entity3 with @entity5 and to determine diagnostic and predictive values of @entity4 protein and @entity8 expression. MATERIAL AND METHOD: Tissue samples from @entity5 were obtained from 31 @entity0 who underwent pancreticoduodenectomy for @entity3 . The study group was composed of 12 @entity0 and 19 @entity0 . Their median age was found to be 62.32 years (range 26-85 years). The parameters analyzed in the study included lymph node @entity1 , perineural invasion, differentiation, duodenal invasion, grade of @entity9 and @entity4 and @entity8 expression in tumoral and peritumoral pancreatic tissues. RESULTS: In both @entity2 groups, the loss of @entity4 protein expression was significantly correlated with perineural invasion (p = 0.0001). Perineural invasion was more frequent in the @entity5 group than the ampulla of @entity3 group (p = 0.01). When desmoplasia and lymphoplasmacytic stromal infiltration were examined, desmoplastic reaction was significantly higher in @entity5 than ampulla of @entity3 (p = 0.01). No significant difference was observed between @entity2 groups for @entity8 (p > 0.05). CONCLUSION: The results suggest that loss of @entity4 protein expression may be a sign for poor prognosis in @entity2 that is correlated mainly with perineural invasion. @entity6 stromal reaction may be a distinctive feature for @entity5 compared with ampulla of @entity3 .

title: Expression of @entity4 protein and XXXX in periampullary @entity3 .

answer: @entity8


abstract: To evaluate the status of @entity4 in inhabitants of Gangweon-Do, Korea, a total of 1,310 stool specimens (male 669, female 641) was collected from 2 cities and 3 counties. They were examined routinely 1 time by the method of @entity0 -ether sedimentation technique. The results were as follows: 1. The positive rate for any kind of the intestinal protozoan cysts was 8.9 %. 2. A total of 6 kinds of the intestinal protozoan cysts were detected. The prevalence rate of each protozoa were; @entity3 0.8 %, @entity2 7.6 %, E. nana 1.4 %, I. butschlii 0.2 %, @entity1 0.5 % and C. mesnili 0.5 %. 3. Sogcho-city showed the highest positive rate as 15.2 %, Myeongju county was the next as 11.3 % and Weonju-city showed the lowest positive rate as low as 3.9 %. 4. By age, the highest positive rate was found in 20-29 age group(12.4 %). Female (9.5 %) showed a slight higher positive rate than male (8.4 %).

title: [The Status Of XXXX In Inhabitants Of Gangweon-Do, Korea]

answer: @entity4


abstract: The purpose of this study was to determine the effect of an immunostimulative polymer, @entity8 (Cpv), plus antibiotics ( @entity6 and @entity5 ) in a @entity1 model of @entity3 . @entity7 augments humoral immunity with little effect on T cells and is nontoxic. @entity7 100 mg/kg iv administered at the onset of @entity2 increased @entity4 ( @entity4 ) by 40-55% over untreated controls. Four experiments were performed. @entity7 in combination with antibiotics when given at the time of onset of @entity2 was significantly more effective than antibiotics alone ( @entity4 235 vs 105 hr, P less than 0.05 at 144, 168, 192, 216 hr). In the second and third experiments @entity7 alone and with antibiotics was administered 15 hr after the onset of @entity2 . @entity7 significantly augmented survival over controls in the second experiment ( @entity4 87 vs 60 hr, P less than 0.025 at 96 hr). Cpv plus antibiotics was significantly better than antibiotics alone in the third experiment ( @entity4 111 vs 64 hr, P less than 0.05 at 72 hr, P less than 0.005 at 120 hr). In the final experiment, @entity7 did not inhibit growth of 20 bacterial species in agar and liquid media. @entity7 significantly enhances survival in @entity1 @entity3 even when administered after the onset of @entity2 ; furthermore Cpv plus antibiotics in @entity3 produces longer survival than antibiotics alone. Synthetic immunomodulators such as @entity7 could eventually play a significant role in the management of @entity3 in @entity0 .

title: Enhanced survival in antibiotic-treated @entity1 @entity3 by administration of XXXX , a selective immunostimulative polymer.

answer: @entity8


abstract: The purpose of this study was to determine the effect of an immunostimulative polymer, @entity8 (Cpv), plus antibiotics ( @entity6 and @entity5 ) in a @entity1 model of @entity3 . @entity7 augments humoral immunity with little effect on T cells and is nontoxic. @entity7 100 mg/kg iv administered at the onset of @entity2 increased @entity4 ( @entity4 ) by 40-55% over untreated controls. Four experiments were performed. @entity7 in combination with antibiotics when given at the time of onset of @entity2 was significantly more effective than antibiotics alone ( @entity4 235 vs 105 hr, P less than 0.05 at 144, 168, 192, 216 hr). In the second and third experiments @entity7 alone and with antibiotics was administered 15 hr after the onset of @entity2 . @entity7 significantly augmented survival over controls in the second experiment ( @entity4 87 vs 60 hr, P less than 0.025 at 96 hr). Cpv plus antibiotics was significantly better than antibiotics alone in the third experiment ( @entity4 111 vs 64 hr, P less than 0.05 at 72 hr, P less than 0.005 at 120 hr). In the final experiment, @entity7 did not inhibit growth of 20 bacterial species in agar and liquid media. @entity7 significantly enhances survival in @entity1 @entity3 even when administered after the onset of @entity2 ; furthermore Cpv plus antibiotics in @entity3 produces longer survival than antibiotics alone. Synthetic immunomodulators such as @entity7 could eventually play a significant role in the management of @entity3 in @entity0 .

title: Enhanced survival in antibiotic-treated @entity1 XXXX by administration of @entity8 , a selective immunostimulative polymer.

answer: @entity3


abstract: The purpose of this study was to determine the effect of an immunostimulative polymer, @entity8 (Cpv), plus antibiotics ( @entity6 and @entity5 ) in a @entity1 model of @entity3 . @entity7 augments humoral immunity with little effect on T cells and is nontoxic. @entity7 100 mg/kg iv administered at the onset of @entity2 increased @entity4 ( @entity4 ) by 40-55% over untreated controls. Four experiments were performed. @entity7 in combination with antibiotics when given at the time of onset of @entity2 was significantly more effective than antibiotics alone ( @entity4 235 vs 105 hr, P less than 0.05 at 144, 168, 192, 216 hr). In the second and third experiments @entity7 alone and with antibiotics was administered 15 hr after the onset of @entity2 . @entity7 significantly augmented survival over controls in the second experiment ( @entity4 87 vs 60 hr, P less than 0.025 at 96 hr). Cpv plus antibiotics was significantly better than antibiotics alone in the third experiment ( @entity4 111 vs 64 hr, P less than 0.05 at 72 hr, P less than 0.005 at 120 hr). In the final experiment, @entity7 did not inhibit growth of 20 bacterial species in agar and liquid media. @entity7 significantly enhances survival in @entity1 @entity3 even when administered after the onset of @entity2 ; furthermore Cpv plus antibiotics in @entity3 produces longer survival than antibiotics alone. Synthetic immunomodulators such as @entity7 could eventually play a significant role in the management of @entity3 in @entity0 .

title: Enhanced survival in antibiotic-treated XXXX @entity3 by administration of @entity8 , a selective immunostimulative polymer.

answer: @entity1


abstract: Eight cases of primary @entity0 were studied for evidence of heterogeneity by flow cytometry using @entity4 staining of DNA. @entity1 ranged from 2.5 to 8.0 cm in greatest dimension, mean 4.2 cm. Five to 11 samples, determined by @entity1 size, were analyzed from each primary @entity1 in addition to 4 axillary lymph nodal metastases from 3 of the 8 cases. The presence of @entity2 was demonstrated histologically in each flow cytometric sample. Three of the @entity2 showed only diploid DNA content. Three showed the same single @entity3 population in each sample. Two @entity2 (2.5 and 3.5 cm) were heterogeneous and demonstrated 2 or 3 @entity3 populations. The 2 or 3 distinct @entity3 populations were present singly or sometimes in combination in one sample. Five of the 11 samples from 1 of the heterogeneous @entity1 and its axillary metastasis contained a single diploid population. Therefore, flow cytometric analysis of a single sample from a @entity0 may not be representative of the entire @entity1 . The study of multiple samples of @entity0 by flow cytometry is necessary for full characterization of the @entity1 .

title: XXXX determined by flow cytometric analysis.

answer: @entity0


abstract: OBJECTIVE: To study the clinico pathologic factors influencing postoperative survival rate in @entity4 of salivary glands. METHODS: A retrospective study of seventy @entity0 with @entity4 of salivary glands has been carried out. All cases underwent primary surgical resection in our hospital were followed up and clinicopathologic factors influencing the postoperative survival rate of @entity0 were investigated. Statistical analysis was conducted using a computer program (SPSS). The data were statistically treated according to the Kaplan-Meier method. The Log rank tests were employed to assess the statistical significance of various groups. RESULTS: The 3-, 5- and 10-year overall survival rate were 90.66%, 88.85% and 86.63%, respectively. The @entity0 with @entity2 ' diameter less than 4 cm, early clinical stage (stage I and II), well differentiated @entity2 cells, without lymph nodes involvement, without local recurrence and @entity1 after primary surgical resection had a long survival term. The @entity0 with @entity2 ' diameter more than 4 cm, with lymph nodes involvement, advanced clinical stage (stage III and IV), poor differentiated, with local recurrence and @entity1 after primary surgical resection demonstrated a short survival term. CONCLUSION: @entity3 and clinical stage, the degree of differentiation, with or without local recurrence and @entity1 after primary surgical resection are the important factors influencing the postoperative survival time.

title: [Survival rate in XXXX of salivary glands].

answer: @entity4