abstract: BACKGROUND: Based on encouraging treatment results with FU/FA or FU/IFN in @entity10 , a phase II study was conducted to evaluate the effects and @entity3 of combination FU/FA/IFN in @entity0 (pts) with inoperable/metastatic @entity7 . @entity0 AND METHODS: IFN 6 M.U. s.c. 1 x/week, FU 500 mg/m2 bolus i.v. 1 x/week and FA 500 mg/m2 1 x/week as a 2-hour infusion. Of 72 treated pts, 72 (22 females, 50 males) are evaluable for response and @entity3 . Median age was 55.6 years (28-80), and median Karnofsky performance status was 80% (70-100). Sites of measurable disease were inoperable primary @entity2 /local recurrence (18), liver @entity1 (22), lymph nodes (31) and peritoneum (20). One pt had @entity5 and another had paraneoplastic @entity9 . RESULTS: 10/72 pts had complete response, 20/72 pts partial response, 40/72 pts @entity2 stabilization and 2/72 pts progressive disease. The median duration of response (CR/PR) was 9 months, the median progression-free interval 6 months, the median survival time was 9 months, and for responding @entity0 (CR/PR) 12.5 months. @entity3 : 1/72 pts had WHO grade 4 @entity3 ( @entity6 ), 5/72 pts had WHO grade 3 @entity3 ( @entity8 1, @entity6 4). Except for 1 treatment-limiting grade 4 @entity3 , no modifications of dose or schedule due to @entity3 were required. Thirty-six of 44 pts experienced a significant @entity4 under treatment. CONCLUSION: Biochemical modulation of FU with FA and IFN is effective in advanced @entity7 . Moderate @entity3 , outpatient treatment setting and high rates of amelioration @entity2 -related @entity4 contribute to an effective palliation.

title: Combination 5-fluorouracil (FU), folinic acid (FA), and alpha-interferon 2B in advanced XXXX : results of a phase II trial.

answer: @entity7


abstract: BACKGROUND: @entity2 survivors have an increased risk of developing @entity1 ( @entity1 ); this risk is traditionally attributed to the effects of multidisciplinary management required for cure. However, the impact of constitutional predisposition has not been properly analyzed. METHODS: We analyzed the risk of @entity1 among 1,151 @entity0 diagnosed with @entity2 and reported to the Surveillance, Epidemiology, and End Results registries (SEER-9) from 1973 to 2010. Standardized incidence ratios (SIR) and corresponding 95% confidence intervals (CI) were calculated using SEERStat 8.1.2. RESULTS: @entity0 with @entity3 had an increased risk of developing a @entity1 (SIR = 15.77, 95%CI 1.91-56.96 and SIR = 5.6, 95%CI 3.32-8.85, respectively). The risk was age-dependent; the highest was among @entity0 <2 years (SIR = 13.38, 95%CI 4.34-31.22) and the lowest was in @entity0 >10 years (SIR = 3.35, 95%CI 1.53-6.35). The risk for the youngest @entity0 was higher for those with @entity3 (SIR = 14.72, 95%CI 4.01-37.70) compared to other histiotypes. Additionally, the risk of @entity1 was independent of the use of radiation to the primary (SIR = 6.50, 95%CI 3.97-10.03 and SIR = 4.57, 95%CI 2.09-8.68, for @entity0 receiving and not receiving radiation, respectively). The pattern of @entity1 observed was consistent with the @entity4 -Fraumeni spectrum. CONCLUSIONS: @entity0 with @entity2 are at high risk of developing @entity1 . This risk is higher for a subgroup of young @entity0 with pleomorphic and embryonal histologies, and is independent of the use of radiation. This suggests that a subgroup of @entity0 with @entity3 may have a constitutional @entity1 predisposition.

title: An Increased Risk of Second XXXX After @entity2 : Population-Based Evidence for a @entity1 ?

answer: @entity1


abstract: BACKGROUND: @entity2 survivors have an increased risk of developing @entity1 ( @entity1 ); this risk is traditionally attributed to the effects of multidisciplinary management required for cure. However, the impact of constitutional predisposition has not been properly analyzed. METHODS: We analyzed the risk of @entity1 among 1,151 @entity0 diagnosed with @entity2 and reported to the Surveillance, Epidemiology, and End Results registries (SEER-9) from 1973 to 2010. Standardized incidence ratios (SIR) and corresponding 95% confidence intervals (CI) were calculated using SEERStat 8.1.2. RESULTS: @entity0 with @entity3 had an increased risk of developing a @entity1 (SIR = 15.77, 95%CI 1.91-56.96 and SIR = 5.6, 95%CI 3.32-8.85, respectively). The risk was age-dependent; the highest was among @entity0 <2 years (SIR = 13.38, 95%CI 4.34-31.22) and the lowest was in @entity0 >10 years (SIR = 3.35, 95%CI 1.53-6.35). The risk for the youngest @entity0 was higher for those with @entity3 (SIR = 14.72, 95%CI 4.01-37.70) compared to other histiotypes. Additionally, the risk of @entity1 was independent of the use of radiation to the primary (SIR = 6.50, 95%CI 3.97-10.03 and SIR = 4.57, 95%CI 2.09-8.68, for @entity0 receiving and not receiving radiation, respectively). The pattern of @entity1 observed was consistent with the @entity4 -Fraumeni spectrum. CONCLUSIONS: @entity0 with @entity2 are at high risk of developing @entity1 . This risk is higher for a subgroup of young @entity0 with pleomorphic and embryonal histologies, and is independent of the use of radiation. This suggests that a subgroup of @entity0 with @entity3 may have a constitutional @entity1 predisposition.

title: An Increased Risk of Second @entity1 After @entity2 : Population-Based Evidence for a XXXX ?

answer: @entity1


abstract: BACKGROUND: @entity2 survivors have an increased risk of developing @entity1 ( @entity1 ); this risk is traditionally attributed to the effects of multidisciplinary management required for cure. However, the impact of constitutional predisposition has not been properly analyzed. METHODS: We analyzed the risk of @entity1 among 1,151 @entity0 diagnosed with @entity2 and reported to the Surveillance, Epidemiology, and End Results registries (SEER-9) from 1973 to 2010. Standardized incidence ratios (SIR) and corresponding 95% confidence intervals (CI) were calculated using SEERStat 8.1.2. RESULTS: @entity0 with @entity3 had an increased risk of developing a @entity1 (SIR = 15.77, 95%CI 1.91-56.96 and SIR = 5.6, 95%CI 3.32-8.85, respectively). The risk was age-dependent; the highest was among @entity0 <2 years (SIR = 13.38, 95%CI 4.34-31.22) and the lowest was in @entity0 >10 years (SIR = 3.35, 95%CI 1.53-6.35). The risk for the youngest @entity0 was higher for those with @entity3 (SIR = 14.72, 95%CI 4.01-37.70) compared to other histiotypes. Additionally, the risk of @entity1 was independent of the use of radiation to the primary (SIR = 6.50, 95%CI 3.97-10.03 and SIR = 4.57, 95%CI 2.09-8.68, for @entity0 receiving and not receiving radiation, respectively). The pattern of @entity1 observed was consistent with the @entity4 -Fraumeni spectrum. CONCLUSIONS: @entity0 with @entity2 are at high risk of developing @entity1 . This risk is higher for a subgroup of young @entity0 with pleomorphic and embryonal histologies, and is independent of the use of radiation. This suggests that a subgroup of @entity0 with @entity3 may have a constitutional @entity1 predisposition.

title: An Increased Risk of Second @entity1 After XXXX : Population-Based Evidence for a @entity1 ?

answer: @entity2


abstract: @entity1 ( @entity1 ) is a major component of the extracellular matrix and is known to influence cell behaviour and to play a role in angiogenesis, morphogenesis and tissue remodelling, although little is known concerning the regulation of these effects. Until now its detection in the placenta has been by indirect methods, which has led to conflicting conclusions as to its distribution and hence its role. Hyaluronectin (HN) is one of a group of proteins with @entity1 binding ability which may regulate the effects of @entity1 . Although nervous tissue HN has been partly characterised with regard to its distribution, structure and biochemistry, little is known about the mesenchymal isoform and its distribution in placenta has not previously been reported. Using specific probes we have characterised the distribution of @entity1 and HN in @entity0 placental tissue. At all stages of development studied (8, 10, 12, 30 and 38 wk gestation) @entity1 and HN were unequivocally colocalised, being distributed in the extracellular matrix of stromal tissue of placental villi, chorioallantoic membranes and umbilical cord. Particularly strong immunoreactivity was observed in the villous stroma immediately adjacent to fibrinoid depositions at sites of denudation of the trophoblast layer. Extraction and characterisation of the HN from placental villi have revealed 4 major glycoproteins of 47, 52, 57 and 67 kDa, this being a different pattern and smaller molecular range than observed for the nervous tissue form. This is the first direct demonstration of the presence of @entity1 and HN in the placenta and identifies an abundant new source of mesenchymal HN. The functions of mesenchymal HN are unknown but may include ion exchange, immunosuppression and regulation of the effects of @entity1 in such roles as maintenance of tissue architecture, cell migration and angiogenesis.

title: Isolation and characterisation of a hyaluronan binding protein, hyaluronectin, from XXXX placenta and its colocalisation with hyaluronan.

answer: @entity0


abstract: UNASSIGNED: For safe and reliable skull base reconstruction combined with repair of cranial @entity1 , we introduce the @entity4 sandwich technique in this study. A @entity3 mesh is often used to repair structural cranial @entity1 because it has less donor site morbidity and is easy to handle. However, @entity3 mesh has disadvantages of exposure and @entity2 postoperatively. To improve surgical outcomes, we applied the @entity4 sandwich technique to 3 cases of skull base reconstruction combined with cranial @entity1 repair. Two anterior skull base defects and 1 middle skull base defect were included in this study. The subjects were all @entity0 , aged 30, 58, and 62 years. One @entity0 had former multiple craniotomies and another @entity0 had preoperative radiotherapy. The @entity4 sandwich technique involves structural cranial bone reconstruction with a @entity3 mesh and soft tissue reconstruction with a chimeric anterolateral thigh free @entity4 . First, the dead space between the repaired dura and the @entity3 mesh is filled with vastus lateralis muscle, and then structural reconstruction is performed with a @entity3 mesh. Finally, the @entity3 mesh is totally covered with the adiposal @entity4 of the anterolateral thigh free @entity4 . The muscle @entity4 protects the dead space from @entity2 , and the adiposal @entity4 covers the @entity3 mesh to reduce mechanical stress on the covered skin and thus prevent the exposure of the @entity3 mesh through the scalp. By applying this technique, there was no @entity2 or @entity3 mesh exposure in these 3 cases postoperatively, even though 2 @entity0 had postoperative radiotherapy. Additionally, the adiposal @entity4 could provide a soft and natural contour to the scalp and forehead region, and this gives @entity0 a better facial appearance even though they have had skull base surgery.

title: The XXXX Sandwich Technique for a Safe and Aesthetic Skull Base Reconstruction.

answer: @entity4


abstract: BACKGROUND: @entity0 is one of the leading cause of mortality and morbidity in Canada. Screening is the most promising approach in identification and treatment of the disease at early stage of its development. Research shows higher rate of @entity0 mortality among ethno-racial immigrant @entity1 despite their lower incidence which suggests disparities in mammography screening. This study aimed to compare the prevalence of appropriate mammography screening among immigrant and native borne @entity1 and determine predicators of low mammography screening. METHODS: We conducted secondary data analyses on Ontario linked social and health databases to determine the proportion of @entity1 who were screened during the two-year period of 2010-2012 among 1.4 million screening-eligible @entity1 living in urban centres in Ontario. We used multivariate Poisson regression to adjust for various socio-demographic, health care-related and migration related variables. RESULTS: 64% of eligible @entity1 were appropriately screened. Screening rates were lowest among new and recent immigrants compared to referent group (Canadian-born @entity1 and immigrant who arrived before 1985) (Adjusted Rate Ratio (ARR) (0.87, 95% CI 0.85-0.88 for new immigrants and 0.90, 95% CI 0.89-0.91 for recent immigrants. Factors that were associated with lower rates of screening included living in @entity2 , having a male physician, having internationally-trained physician and not being enrolled in primary care @entity1 enrolment models. Those not enrolled were 22% less likely to be screened compared to those who were (ARR 0.78, 95% CI 0.77-0.79). CONCLUSION: To enhance immigrant @entity1 screening rates efforts should made to increase their access to primary care @entity1 enrolment models and preferably female health professionals. Support should be provided to interventions that address screening barriers like language, acculturation limitations and knowledge deficit. Health professionals need to be educated and take an active role in offering screening guidelines during health encounters.

title: XXXX screening disparities among urban immigrants: a population-based study in Ontario, Canada.

answer: @entity0


abstract: OBJECTIVE: Traditionally, skin graft donor sites have been covered with fine-mesh gauze dressings, and a @entity3 has been allowed to form. Newer dressings that can provide a moist wound environment may facilitate reepithelialization. We compared a hydrophilic semipermeable absorbent @entity4 foam dressing that provides a moist wound environment with a petrolatum gauze dressing for donor sites. DESIGN: Prospective randomized trial; follow-up at 14 days. SETTING: Department of head and neck surgery in a tertiary care center. @entity0 : Sixty-eight eligible @entity0 received one of the two dressings. Harvested skin grafts were 0.375-mm (0.015-in) thick; donor site surface areas were recorded. At postoperative day 14, the dressings were removed, and wound epithelialization was scored: 1, none; 2, scattered or spotty; and 3, complete. Donor site and operative site @entity1 intensities were assessed by a visual numeric scale: none (0) to the worst (100) experienced over the preceding 24-hour period. @entity1 scores were available for 58 @entity0 . MAIN OUTCOME MEASURES: Dressings were compared based on these criteria: healing at 14 days, @entity2 , and donor site and operative site @entity1 . RESULTS: A healing score of 3 was seen in 37% (14/38) of @entity0 with hydrophilic semipermeable absorbent @entity4 foam dressings and in 17% (5/30) of @entity0 with petrolatum gauze dressings (P = .06) by day 14. Overall, however, mean healing scores were similar in both groups. Mean healing scores for the @entity0 who received a hydrophilic semipermeable absorbent @entity4 foam dressing was 2.3 (SD = 0.6) vs 2.2 (SD = 0.6) for @entity0 who received the petrolatum gauze dressing (P = .20). Numbers of days required for complete epithelialization in these groups were 20.6 (SD = 10.1) and 19.3 (SD = 5.1), respectively (P = .49). One @entity2 occurred in the group who received the petrolatum gauze dressing. The mean maximum @entity1 intensity scores were lower for those who were given the hydrophilic semipermeable absorbent @entity4 foam dressing on postoperative days 1 through 3 (P = .003, .03, and .04, respectively). @entity1 increased with a larger donor site surface area for the @entity0 with the petrolatum gauze dressing but not for the @entity0 with the hydrophilic semipermeable absorbent @entity4 foam dressing. CONCLUSIONS: The hydrophilic semipermeable absorbent @entity4 foam dressing appears to have potential advantages over the petrolatum gauze dressing; it produces less initial @entity0 donor site discomfort and tends to produce more complete donor site healing by postoperative day 14.

title: Split-thickness skin graft donor site management. A randomized prospective trial comparing a hydrophilic XXXX absorbent foam dressing with a petrolatum gauze dressing.

answer: @entity4


abstract: INTRODUCTION: In degenerative @entity1 ( @entity1 ), @entity4 and @entity5 ( @entity6 ) correlate with clinical symptomatology. @entity6 is defined as @entity3 with lateral listhesis. Stereoradiography, recently developed for medical applications, provides full-body standing radiographs and 3D reconstruction of the spine, with low radiation dose. HYPOTHESIS: 3D stereoradiography improves analysis of @entity6 and of its relations with transverse plane and spinopelvic parameters and clinical impact. MATERIAL AND METHODS: One hundred and thirty adults with lumbar @entity1 and full-spine EOS   radiographs (EOS Imaging, Paris, France) were included. Spinopelvic sagittal parameters and lateral listhesis in the coronal plane were measured. The transverse plane study parameters were: apical axial @entity3 (apex @entity7 ), axial intervertebral rotation (AIR) and torsion index (TI). Two groups were compared: with @entity6 (lateral listhesis>5mm) and without @entity6 (without lateral listhesis exceeding 5mm: @entity6 ). Correlations between radiologic and clinical data were assessed. RESULTS: @entity6 @entity0 were significantly older, with larger Cobb angle (37.4   vs. 26.6  , P=0.0001), more severe @entity1 , and greater apex @entity7 (respectively: 22.9   vs. 11.3  , P<0.001; and 41.0   vs. 19.9  , P<0.001). Ten percent of @entity0 had AIR>10   without visible @entity6 on 2D radiographs. @entity6 @entity0 reported significantly more frequent low back @entity2 and radiculalgia. DISCUSSION: In this EOS   study, @entity1 @entity0 with @entity6 had greater coronal curvature and sagittal and transverse deformity, as well as greater @entity2 . Further transverse plane analysis could allow earlier diagnosis and prognosis to guide management. LEVEL OF EVIDENCE: 4, retrospective study.

title: Clinical and stereoradiographic analysis of adult XXXX .

answer: @entity1


abstract: BACKGROUND: Selection of @entity2 treatment fundamentally relies on staging of the underlying @entity2 . The aim of this study was to evaluate the feasibility and effectiveness of laparoscopic narrow band imaging (NBI) for operative staging and detection of occult peritoneal @entity2 @entity1 . METHODS: A randomized, controlled feasibility trial with crossover design evaluating adult @entity0 with gastrointestinal or gynecologic @entity2 who have a clinical indication for diagnostic laparoscopy was conducted. Twenty-three @entity0 were randomized to white-light followed by NBI laparoscopy (n  =  11) or NBI followed by white-light laparoscopy (n  =  12) using the Olympus Evis Exera II system. Three @entity0 were excluded from analysis. RESULTS: In all 20 study @entity0 , the abdominal cavity was sufficiently illuminated. An enhanced contrast of microvasculature and organ surface pattern was appreciated. Eight of the 20 @entity0 (40  %) were found to have @entity1 of the peritoneal surface. While NBI did not show any additional peritoneal lesions, 2 of the 63 suspicious-appearing nodules seen on white-light imaging were not visible on NBI (p  =  0.50). The median diameter of all the nodules identified was 2  mm (range 1-50  mm) and was identical with each method. CONCLUSIONS: The information from this feasibility study demonstrated that NBI provides adequate illumination of the abdominal cavity and a unique contrast that enhances microvasculature and architectural surface pattern. The results suggest that NBI laparoscopy is not superior in detecting peritoneal @entity1 compared to standard white-light laparoscopy, but might provide a technology that could be applied for other abdominal pathologies.

title: Laparoscopic narrow band imaging for detection of occult @entity2 XXXX : a randomized feasibility trial.

answer: @entity1


abstract: BACKGROUND: Selection of @entity2 treatment fundamentally relies on staging of the underlying @entity2 . The aim of this study was to evaluate the feasibility and effectiveness of laparoscopic narrow band imaging (NBI) for operative staging and detection of occult peritoneal @entity2 @entity1 . METHODS: A randomized, controlled feasibility trial with crossover design evaluating adult @entity0 with gastrointestinal or gynecologic @entity2 who have a clinical indication for diagnostic laparoscopy was conducted. Twenty-three @entity0 were randomized to white-light followed by NBI laparoscopy (n  =  11) or NBI followed by white-light laparoscopy (n  =  12) using the Olympus Evis Exera II system. Three @entity0 were excluded from analysis. RESULTS: In all 20 study @entity0 , the abdominal cavity was sufficiently illuminated. An enhanced contrast of microvasculature and organ surface pattern was appreciated. Eight of the 20 @entity0 (40  %) were found to have @entity1 of the peritoneal surface. While NBI did not show any additional peritoneal lesions, 2 of the 63 suspicious-appearing nodules seen on white-light imaging were not visible on NBI (p  =  0.50). The median diameter of all the nodules identified was 2  mm (range 1-50  mm) and was identical with each method. CONCLUSIONS: The information from this feasibility study demonstrated that NBI provides adequate illumination of the abdominal cavity and a unique contrast that enhances microvasculature and architectural surface pattern. The results suggest that NBI laparoscopy is not superior in detecting peritoneal @entity1 compared to standard white-light laparoscopy, but might provide a technology that could be applied for other abdominal pathologies.

title: Laparoscopic narrow band imaging for detection of occult XXXX @entity1 : a randomized feasibility trial.

answer: @entity2


abstract: BACKGROUND: @entity3 ( @entity3 ) is one of the most common bariatric procedures worldwide, but the importance of gastric pouch size is still under debate. We have studied how pouch size affects risk of marginal @entity4 and excess body mass index loss (EBMIL%) at 6  weeks and 1  year postoperatively. METHODS: Scandinavian Obesity Surgery Registry included 14,168 @entity3 @entity0 with linear stapled gastrojejunostomies, having complete pre- and postoperative data concerning length of stapler needed to complete the gastric pouch, incidence of @entity5 and @entity2 . @entity3 technique in Sweden is highly standardized, and total length of stapler was used as a proxy for pouch size. RESULTS: Mean length of stapler used for the pouch was 145  mm. At 1  year, symptomatic @entity5 were noted in 0.9  % of the @entity0 . The relative risk of marginal @entity4 increased by 14  % (95  % confidence interval 9-20  %), for each centimeter of stapler used for the pouch. Body mass index (BMI) was reduced from 42.4      5.1 to 36.1  kg/m(2) at 6  weeks and 28.9  kg/m(2) at 1  year. The total length of stapler predicted EBMIL% at 6  weeks but not at 1  year. Female gender, low preoperative BMI, young age and absence of @entity1 predicted better EBMIL% at 1  year. CONCLUSION: A smaller pouch reduces the risk of @entity5 , but does not predict better @entity2 at 1  year. Additional stapling should be avoided as each extra centimeter increases the relative risk of @entity5 by 14  %.

title: Importance of pouch size in laparoscopic Roux-en-Y gastric bypass: a cohort study of 14,168 XXXX .

answer: @entity0


abstract: OBJECTIVE: To compare the accuracy of multiparametric magnetic resonance imaging (MP-MRI) with the Partin tables and Memorial Sloan-Kettering (MSK) nomogram for predicting extracapsular extension (ECE) in @entity1 and to create a tool for clinicians to estimate pathologic ECE  risk. METHODS: A retrospective review of 112 @entity0 who underwent 3T MP-MRI of the prostate and radical prostatectomy was performed. Regression analyses were carried out to identify predictors of ECE. Predictive accuracy of models based on nomogram and MP-MRI were compared. RESULTS: A total of 33 of @entity0 (29%) had ECE on MP-MRI whereas 26 @entity0 (23%) had ECE on final pathology. Mean age was 62.8  years and mean @entity2 was 8.2  ng/dL. MRI was a significant predictor of ECE that was independent of age, @entity2 , Gleason score, clinical stage, and percent positive cores on biopsy. Sensitivity, specificity, positive predictive value, and negative predictive value of MP-MRI for ECE were 84.6%, 87.2%, 66.7%, and 94.9%, respectively. Areas under the curve for Partin and MSK nomograms for predicting ECE were 0.85 and 0.86, respectively. Area under the curve increased to 0.92 and 0.94, respectively, when MP-MRI was added to each nomogram. We provide an online tool that integrates Partin or MSK nomogram results with ECE status determined from MRI to predict pathologic ECE. Within the typical range of risks for ECE provided by the clinical nomograms (ie, 15%-40%), MRI was useful for predicting pathologic ECE. CONCLUSION: MP-MRI may be a useful adjunct for clinically staging @entity1 . MP-MRI improved accuracy of existing clinical nomograms for prediction of pathologic ECE.

title: Multiparametric MRI Improves Accuracy  of Clinical Nomograms for Predicting Extracapsular Extension of  XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity2 is one of the most common causes of @entity1 morbidity both in @entity0 and in @entity0 . However, females over 65 years old show higher mortality and lower 5-year survival rate of @entity2 compared to their age-matched male counterparts. The objective of this review is to suggest gender-based innovations to improve @entity2 outcomes in females. @entity0 have a higher risk of developing right-sided (proximal) @entity4 than @entity0 , which is associated with more aggressive form of @entity1 compared to left-sided (distal) @entity4 . Despite differences in @entity1 location between @entity0 and @entity0 , most of scientific researchers do not consider sex specificity for study design and interpretation. Also, @entity2 screening guidelines do not distinguish females from male, which may explain the higher frequency of more @entity5 when @entity1 are first detected and false negative results in colonoscopy in females. Moreover, socio-cultural barriers within females are present to delay screening and diagnosis. Few studies, among studies that included both @entity0 and @entity0 , have reported sex-specific estimates of dietary risk factors which are crucial to establish @entity1 prevention guidelines despite sex- and gender-associated differences in nutrient metabolism and dietary practices. Furthermore, anti- @entity1 drug use for @entity2 treatment can cause @entity3 to the reproductive system, and gender-specific recurrence and survival rates are reported. Therefore, by understanding sex- and gender-related biological and socio-cultural differences in @entity2 risk, gender-specific strategies for screening, treatment and prevention protocols can be established to reduce the mortality and improve the quality of life.

title: Sex- and gender-specific disparities in XXXX risk.

answer: @entity2


abstract: This study surveys the improvement characteristics in old-aged muscular mitochondria by bio-active materials coated fabric (BMCF). To observe the effects, the fabric (10 and 30%) was worn to old-aged @entity1 then the @entity0 consumption efficiency and copy numbers of mitochondria, and mRNA expression of apoptosis- and mitophagy-related genes were verified. By wearing the BMCF, the oxidative respiration significantly increased when using the 30% materials coated fabric. The mitochondrial DNA copy number significantly decreased and subsequently recovered in a dose-dependent manner. The respiratory control ratio to mitochondrial DNA copy number showed a dose-dependent increment. As times passed, @entity3 , @entity4 , @entity6 and b-actin increased, and @entity2 decreased in a dose-dependent manner. However, the BMCF can be seen to have had no effect on @entity7 . @entity8 expression did not change considerably and was inclined to decrease in control group, but the expression was down-regulated then subsequently increased with the use of the BMCF in a dose-dependent manner. @entity5 increased and subsequently decreased in a dose-dependent manner. These results suggest that the BMCF invigorates mitophagy and improves mitochondrial oxidative respiration in skeletal muscle, and in early stage of apoptosis induced by the BMCF is not related to extrinsic death-receptor mediated but mitochondria-mediated signaling pathway.

title: Improvement Characteristics of Bio-active Materials Coated Fabric on XXXX Muscular Mitochondria.

answer: @entity1


abstract: OBJECTIVE: To investigate the quantitative relationship, if any, between signal averaged electrocardiographic variables and echocardiographically determined left ventricular mass in @entity1 subjects. DESIGN: Cohort analytic prospective study. SETTING: University hospital. SUBJECTS: 50 @entity1 subjects selected consecutively from inpatients. @entity0 older than 75 years, with underlying @entity2 , with inconclusive echocardiograms with @entity5 , or in @entity3 were excluded. INTERVENTIONS: Antihypertensive therapy involving 41 @entity0 was continued. MAIN OUTCOME MEASURES: Left ventricular mass calculated in accordance with the standards of the Penn convention. Thirteen criteria derived from combinations of signal averaged electrocardiographic X, Y, and Z Frank orthogonal leads, including voltage criteria, duration, and time-voltage integrals of the QRS complex. Four widely used standard electrocardiographic criteria for detection of @entity4 . RESULTS: There was no difference in the values for any of the electrocardiographic variables between @entity0 with (n = 29) and without @entity4 (n = 21). The time-voltage integral of QRS in the horizontal plane was the best signal averaged variable related to left ventricular mass (r = 0.33, P = 0.019); however, the correlation with Rodstein voltage was stronger (r = 0.46, P = 0.0009). A positive correlation was also found between left ventricular indexed mass and Rodstein voltage (r = 0.43, P = 0.0019). Stepwise regression analysis revealed Rodstein voltage as the only predictor of indexed mass (P = 0.0019), and Rodstein voltage (P = 0.0022) and body weight (P = 0.011) as the only independent correlates of left ventricular mass. CONCLUSIONS: The relation between electrocardiographic variables and left ventricular mass or indexed mass is of limited value; signal averaged orthogonal leads do not improve this assessment compared with standard electrocardiographic leads.

title: Determination of left ventricular mass in systemic XXXX : comparison of standard and signal averaged electrocardiography.

answer: @entity1


abstract: This study combined moist airtight storage of moist grain with @entity2 feed fermentation. Starter cultures with the potential to facilitate both technologies were added to airtight stored moist crimped cereal grain, and the impact on storage microflora and the quality of feed fermentations generated from the grain was investigated. Four treatments were compared: three based on moist @entity3 , either un-inoculated (M), inoculated with Wickerhamomyces anomalus (W), or inoculated with W. anomalus and @entity7 starter culture, containing @entity4 DSM 16243, @entity6 DSM 12834 and @entity1 DSM 12837 (WLAB); and one treatment based on dried @entity3 (D). After 6 weeks of storage, four feed fermentations FM, FW, FWLAB, and @entity5 , were initiated from M, W, WLAB, and D, respectively, by mixing the grain with water to a dry matter content of 30%. Each treatment was fermented in batch initially for 7 days and then kept in a continuous mode by adding new feed daily with 50% back-slop. During the 6 week storage period, the average water activity decreased in M, W and WLAB from 0.96 to 0.85, and cereal pH decreased from approximately 6.0 at harvest to 4.5. Feed fermentation conferred a further pH decrease to 3.8-4.1. In M, W and WLAB, molds and Enterobacteriaceae were mostly below detection limit, whereas both organism groups were detected in D. In fermented feed, Enterobacteriaceae were below detection limit in almost all conditions. Molds were detected in @entity5 , for most of the fermentation time in FM and at some sampling points in FW and FWLAB. Starter organisms, especially W. anomalus and @entity1 comprised a considerable proportion of the @entity0 and LAB populations, respectively, in both stored grain and fermented feed. However, autochthonous Pichia kudriavzevii and Kazachstania exigua partially dominated the @entity0 populations in stored grain and fermented feed, respectively.

title: Combined moist airtight storage and feed fermentation of XXXX by the @entity0 Wickerhamomyces anomalus and a lactic acid bacteria consortium.

answer: @entity3


abstract: This study combined moist airtight storage of moist grain with @entity2 feed fermentation. Starter cultures with the potential to facilitate both technologies were added to airtight stored moist crimped cereal grain, and the impact on storage microflora and the quality of feed fermentations generated from the grain was investigated. Four treatments were compared: three based on moist @entity3 , either un-inoculated (M), inoculated with Wickerhamomyces anomalus (W), or inoculated with W. anomalus and @entity7 starter culture, containing @entity4 DSM 16243, @entity6 DSM 12834 and @entity1 DSM 12837 (WLAB); and one treatment based on dried @entity3 (D). After 6 weeks of storage, four feed fermentations FM, FW, FWLAB, and @entity5 , were initiated from M, W, WLAB, and D, respectively, by mixing the grain with water to a dry matter content of 30%. Each treatment was fermented in batch initially for 7 days and then kept in a continuous mode by adding new feed daily with 50% back-slop. During the 6 week storage period, the average water activity decreased in M, W and WLAB from 0.96 to 0.85, and cereal pH decreased from approximately 6.0 at harvest to 4.5. Feed fermentation conferred a further pH decrease to 3.8-4.1. In M, W and WLAB, molds and Enterobacteriaceae were mostly below detection limit, whereas both organism groups were detected in D. In fermented feed, Enterobacteriaceae were below detection limit in almost all conditions. Molds were detected in @entity5 , for most of the fermentation time in FM and at some sampling points in FW and FWLAB. Starter organisms, especially W. anomalus and @entity1 comprised a considerable proportion of the @entity0 and LAB populations, respectively, in both stored grain and fermented feed. However, autochthonous Pichia kudriavzevii and Kazachstania exigua partially dominated the @entity0 populations in stored grain and fermented feed, respectively.

title: Combined moist airtight storage and feed fermentation of @entity3 by the XXXX Wickerhamomyces anomalus and a lactic acid bacteria consortium.

answer: @entity0


abstract: 24 @entity0 (median age 71.5 years) with inoperable proximal @entity1 were treated by insertion of endoscopic endoprostheses from January 1991 to August 1994. 10 @entity0 had @entity7 , 6 @entity1 of body or tail of pancreas, 5 @entity2 and 3 other metastatic malignancy, respectively. 13 @entity0 had type I, 10 had type II and 1 had @entity8 (Bismuth classification). @entity4 or dislocation required a secondary stent insertion in 9 @entity0 . In all cases there was adequate biliary drainage after stent insertion. Complications were: early @entity3 developed in 2 @entity0 , late @entity3 in 5, stent dislocation in 3. One @entity0 underwent an operation because of necrotising @entity9 and @entity5 . There was no bleeding, retroperitoneal perforation or @entity6 . 18 @entity0 died (median survival time 28 weeks) and 6 have been alive at the time of review for 15 weeks in average. Endoscopic stent insertion can be applied effectively also in the palliative treatment of proximal @entity1 .

title: [Palliative endoscopic treatment of proximal XXXX ].

answer: @entity1


abstract: BACKGROUND AND OBJECTIVE: There is a concern on safety of @entity0 Fresh Frozen Plasma (FFP) as it is a source of some medicinal products. The possibility of transmission of blood-borne are reported often due to emerging viruses. There are some Pathogen Reduction Technologies (PRT) to inactivate viruses. @entity4 (MB) based method is one of them. The aim of this study was to examine new designated device to inactivate model viruses. MATERIALS AND METHODS: Four model viruses were used in this study: @entity5 virus (VSV), Herpes Simplex Virus I ( @entity2 ), @entity1 Viral DiarrheaVirus( @entity3 ) and Polio Virus.50% Tissue Culture Infective Dose (TCID 50) and Reed-Muench Methods were used to titer the viruses. MB in two final concentration of 0.1  M and 1  M and illumination in about 627nm with red LED (Lamp Emitting Diode) for 15, 30, 45 and 60 minutes were used. Three replicates employed for each experiments. RESULTS: 1 Mconcentration of MB showed more effective than 0.1 Min all designed illumination period for inactivation of HSV, VSV and @entity3 . This method also demonstrated best results for enveloped model viruses. The most Log reduction for HSV, VSV and @entity3 were6.28, 5.54 and 6.22, respectively. For HSV and @entity3 inactivation, the best illumination period was 45 minutes. CONCLUSION: Model viruses showed sensitivity combination of MB and illumination using red LEDs. As results show this device could inactivate model viruses and reduce their titer very close to approved commercial devices, in compare.

title: Inactivation of model viruses suspended in fresh frozen plasma using novel XXXX based device.

answer: @entity4


abstract: @entity3 with impaired bioavailability of @entity7 (NO) is the hallmark in the development of @entity2 . @entity3 leads to @entity6 , characterized by chronic inflammation of the arterial wall and stepwise narrowing of the vessel lumen. @entity6 causes deprivation of adequate tissue blood flow with compromised @entity0 supply. To overcome this undersupply, remodeling of the vascular network is necessary to reconstitute and sustain tissue viability. This physiological response is often not sufficient and therapeutic angiogenesis remains an unmet medical need in @entity1 or @entity4 . Feasible approaches to promote blood vessel formation are sparse. Administration of pro-angiogenic factors, gene therapy, or targeting of microRNAs has not yet entered the daily practice. @entity7 is an important mediator of angiogenesis that becomes limited under @entity1 conditions and the maintenance of NO availability might constitute an attractive therapeutic target. Until recently it was unknown how the organism provides NO under @entity1 . In recent years it could be demonstrated that NO can be formed independently of its enzymatic synthesis in the endothelium by reduction of inorganic @entity10 under @entity5 conditions. Circulating @entity10 derives from oxidation of NO or reduction of inorganic @entity8 by commensal bacteria in the oral cavity. Intriguingly, @entity8 is a common constituent of our everyday diet and particularly high concentrations are found in leafy green vegetables such as @entity9 , lettuce, or beetroot. Evidence suggests that dietary @entity8 supplementation increases the regenerative capacity of @entity1 tissue and that this effect may offer an attractive nutrition-based strategy to improve @entity1 -induced revascularization. We here summarize and discuss the regenerative capacity of dietary @entity8 on the vascular system.

title: Potential of dietary XXXX in angiogenesis.

answer: @entity8


abstract: AIM: To compare the performance of the re-expressed Modification of Diet in @entity1 equation vs the new @entity3 Epidemiology Collaboration equation in @entity0 with non-valvular @entity4 . METHODS: We studied 911 consecutive @entity0 with non-valvular @entity4 on @entity6 antagonist. The performance of the re-expressed Modification of Diet in @entity1 equation vs the new @entity3 Epidemiology Collaboration equation in @entity0 with non-valvular @entity4 with respect to either a composite endpoint of major @entity2 , @entity5 events and all-cause mortality or each individual component of the composite endpoint was assessed using continuous and categorical >=  60, 59-30, and < 30 mL/min per 1.73 m(2) estimated glomerular filtration rate. RESULTS: During 10    3 mo, the composite endpoint occurred in 98 (10.8%) @entity0 : 30 @entity0 developed major @entity2 , 18 had @entity5 events, and 60 died. The new equation provided lower prevalence of @entity1 < 60 mL/min per 1.73 m(2) (32.9%), compared with the re-expressed equation (34.1%). Estimated glomerular filtration rate from both equations was independent predictor of composite endpoint (HR = 0.98 and 0.97 for the re-expressed and the new equation, respectively; P < 0.0001) and all-cause mortality (HR = 0.98 for both equations, P < 0.01). Strong association with @entity5 events was observed only when estimated glomerular filtration rate was < 30 mL/min per 1.73 m(2): HR is 5.1 for the re-expressed equation, and HR = 5.0 for the new equation. No significant association with major @entity2 was observed for both equations. CONCLUSION: The new equation reduced the prevalence of @entity1 . Both equations performed similarly in predicting major adverse outcomes.

title: Renal function assessment in @entity4 : Usefulness of @entity3 epidemiology collaboration vs re-expressed 4 variable modification of diet in XXXX .

answer: @entity1


abstract: AIM: To compare the performance of the re-expressed Modification of Diet in @entity1 equation vs the new @entity3 Epidemiology Collaboration equation in @entity0 with non-valvular @entity4 . METHODS: We studied 911 consecutive @entity0 with non-valvular @entity4 on @entity6 antagonist. The performance of the re-expressed Modification of Diet in @entity1 equation vs the new @entity3 Epidemiology Collaboration equation in @entity0 with non-valvular @entity4 with respect to either a composite endpoint of major @entity2 , @entity5 events and all-cause mortality or each individual component of the composite endpoint was assessed using continuous and categorical >=  60, 59-30, and < 30 mL/min per 1.73 m(2) estimated glomerular filtration rate. RESULTS: During 10    3 mo, the composite endpoint occurred in 98 (10.8%) @entity0 : 30 @entity0 developed major @entity2 , 18 had @entity5 events, and 60 died. The new equation provided lower prevalence of @entity1 < 60 mL/min per 1.73 m(2) (32.9%), compared with the re-expressed equation (34.1%). Estimated glomerular filtration rate from both equations was independent predictor of composite endpoint (HR = 0.98 and 0.97 for the re-expressed and the new equation, respectively; P < 0.0001) and all-cause mortality (HR = 0.98 for both equations, P < 0.01). Strong association with @entity5 events was observed only when estimated glomerular filtration rate was < 30 mL/min per 1.73 m(2): HR is 5.1 for the re-expressed equation, and HR = 5.0 for the new equation. No significant association with major @entity2 was observed for both equations. CONCLUSION: The new equation reduced the prevalence of @entity1 . Both equations performed similarly in predicting major adverse outcomes.

title: Renal function assessment in XXXX : Usefulness of @entity3 epidemiology collaboration vs re-expressed 4 variable modification of diet in @entity1 .

answer: @entity4


abstract: AIM: To compare the performance of the re-expressed Modification of Diet in @entity1 equation vs the new @entity3 Epidemiology Collaboration equation in @entity0 with non-valvular @entity4 . METHODS: We studied 911 consecutive @entity0 with non-valvular @entity4 on @entity6 antagonist. The performance of the re-expressed Modification of Diet in @entity1 equation vs the new @entity3 Epidemiology Collaboration equation in @entity0 with non-valvular @entity4 with respect to either a composite endpoint of major @entity2 , @entity5 events and all-cause mortality or each individual component of the composite endpoint was assessed using continuous and categorical >=  60, 59-30, and < 30 mL/min per 1.73 m(2) estimated glomerular filtration rate. RESULTS: During 10    3 mo, the composite endpoint occurred in 98 (10.8%) @entity0 : 30 @entity0 developed major @entity2 , 18 had @entity5 events, and 60 died. The new equation provided lower prevalence of @entity1 < 60 mL/min per 1.73 m(2) (32.9%), compared with the re-expressed equation (34.1%). Estimated glomerular filtration rate from both equations was independent predictor of composite endpoint (HR = 0.98 and 0.97 for the re-expressed and the new equation, respectively; P < 0.0001) and all-cause mortality (HR = 0.98 for both equations, P < 0.01). Strong association with @entity5 events was observed only when estimated glomerular filtration rate was < 30 mL/min per 1.73 m(2): HR is 5.1 for the re-expressed equation, and HR = 5.0 for the new equation. No significant association with major @entity2 was observed for both equations. CONCLUSION: The new equation reduced the prevalence of @entity1 . Both equations performed similarly in predicting major adverse outcomes.

title: Renal function assessment in @entity4 : Usefulness of XXXX epidemiology collaboration vs re-expressed 4 variable modification of diet in @entity1 .

answer: @entity3


abstract: PURPOSE: To examine the existence of novel protein products of the @entity0 lacrimal gland. METHODS: cDNA clones corresponding to a highly abundant @entity0 lacrimal gland mRNA were isolated and sequenced. Tissue distribution of expression was studied by Northern blot analysis, RNase protection analysis, and in situ hybridization. RESULTS: A highly abundant 600-base mRNA was identified, and corresponding cDNA clones were isolated. The mRNA has a 134-residue open reading frame encoding a secreted protein of 13458 Da. This protein shows 45.5% similarity to @entity0 salivary acidic @entity1 -rich protein PRP 1 and has a similar domain structure, but, unlike other members of the @entity1 -rich protein family, it lacks a conserved repetitive domain. The lacrimal @entity1 -rich protein is encoded by a single gene, designated as @entity2 . Expression of @entity2 was also detected in the @entity0 submandibular, von Ebners, sublingual, and parotid glands. @entity2 was expressed in the acinar cells of the lacrimal gland, and in the submandibular gland expression of the @entity2 and PRP 1 genes was localized to the serous acini and demilunes. CONCLUSIONS: The @entity0 lacrimal gland produces a previously unknown member of the @entity1 -rich protein family. By analogy with other @entity1 -rich proteins, this @entity2 most likely mediates protective functions in the eye, such as modulation of the microflora. In contrast to other @entity1 -rich protein genes, @entity2 is expressed in the lacrimal acinar cells, and other anterior exocrine glands. @entity2 should be a useful marker for @entity0 lacrimal gland acinar cell function in vitro.

title: A major @entity0 lacrimal gland mRNA encodes a new XXXX -rich protein family member.

answer: @entity1


abstract: PURPOSE: To examine the existence of novel protein products of the @entity0 lacrimal gland. METHODS: cDNA clones corresponding to a highly abundant @entity0 lacrimal gland mRNA were isolated and sequenced. Tissue distribution of expression was studied by Northern blot analysis, RNase protection analysis, and in situ hybridization. RESULTS: A highly abundant 600-base mRNA was identified, and corresponding cDNA clones were isolated. The mRNA has a 134-residue open reading frame encoding a secreted protein of 13458 Da. This protein shows 45.5% similarity to @entity0 salivary acidic @entity1 -rich protein PRP 1 and has a similar domain structure, but, unlike other members of the @entity1 -rich protein family, it lacks a conserved repetitive domain. The lacrimal @entity1 -rich protein is encoded by a single gene, designated as @entity2 . Expression of @entity2 was also detected in the @entity0 submandibular, von Ebners, sublingual, and parotid glands. @entity2 was expressed in the acinar cells of the lacrimal gland, and in the submandibular gland expression of the @entity2 and PRP 1 genes was localized to the serous acini and demilunes. CONCLUSIONS: The @entity0 lacrimal gland produces a previously unknown member of the @entity1 -rich protein family. By analogy with other @entity1 -rich proteins, this @entity2 most likely mediates protective functions in the eye, such as modulation of the microflora. In contrast to other @entity1 -rich protein genes, @entity2 is expressed in the lacrimal acinar cells, and other anterior exocrine glands. @entity2 should be a useful marker for @entity0 lacrimal gland acinar cell function in vitro.

title: A major XXXX lacrimal gland mRNA encodes a new @entity1 -rich protein family member.

answer: @entity0


abstract: INTRODUCTION: @entity2 is the second most common @entity1 in @entity0 , the most common cause of @entity1 deaths, and most @entity0 have advanced stage disease at the time of diagnosis. The purpose of this study was to estimate the 5-year survival of @entity0 with @entity2 based on age, @entity1 histology, stage of disease, and type of treatment. METHODS: This study was conducted on 120 @entity0 with @entity2 referred to Shahid Sadoughi hospital and Shah Vali oncology clinic of Yazd from 2006 to 2012. Demographic data and @entity0 records were studied to evaluate the treatment outcome, @entity1 , and stage of disease. Finally, the overall survival rate and @entity1 -free survival of @entity0 was assessed. RESULTS: The mean @entity0 age was 53.87   14.11 years. Most @entity0 had stage I (36.7%) or stage II (35%) disease. @entity3 (57.6%) was the most common pathology found in @entity0 with @entity2 . The overall survival of @entity0 in this study was significantly associated with the histological @entity1 type (p = 0.000) and disease stage (p = 0.0377). Stage I (84.18%) and @entity3 (72.81%) demonstrated the best survival. The @entity1 -free survival rates were not associated with histology types (p = 0.079), surgical procedure (p = 0.18), or chemotherapy (p = 0.18). CONCLUSION: The survival of @entity0 with @entity2 was significantly associated with disease stage. @entity3 also had the best prognosis among the pathologies studied. Therefore, early detection of @entity2 can substantially increase the survival rate.

title: The Clinicopathologic Characteristics and 5-year Survival Rate of XXXX in Yazd, Iran.

answer: @entity2


abstract: The bacterial superantigen staphylococcal enterotoxin A (SEA) is a highly potent activator of cytotoxic T cells when presented on MHC class II molecules of target cells. Our earlier studies showed that such SEA-directed T cells efficiently killed chronic @entity9 ( @entity1 ) cells. With the ultimate goal to replace the natural specificity of SEA for MHC class II molecules with the specificity of a monoclonal antibody (mAb), we initially made a mutated protein A-SEA (PA-SEAm) fusion protein with > 100-fold reduced binding affinity for MHC class II compared to native SEA. The fusion protein was successfully used to direct T cells to @entity1 cells coated with different B lineage specific ( @entity2 , @entity6 ) or associated ( @entity10 , @entity7 ) mAbs. The PA-SEAm protein was 10-100-fold more potent against mAb coated compared to uncoated HLA class II+ @entity1 cells. No correlation was seen between the amount of mAb bound to the cell surface and sensitivity to lysis. Preactivation of @entity1 cells by @entity8 increased their sensitivity, and lysis was dependent on @entity5 molecules. However, no preactivation of the target cells was needed when a cocktail of two or four mAbs was used. Circulating @entity4 and spleen cells were equally well killed. We conclude that the natural target specificity of SEA, MHC class II, can be reduced by mutagenesis and novel binding specificity can be introduced by linkage to @entity0 reactive mAbs. Our findings encourage the construction of recombinant SEA mutant fusion proteins for specific T cell therapy of @entity3 such as @entity1 .

title: Antibodies are capable of directing superantigen-mediated T cell killing of chronic XXXX cells.

answer: @entity9


abstract: A mechanism-based model was developed to characterize the crosstalk between proinflammatory cytokines, bone remodeling biomarkers, and bone mineral density (BMD) in collagen-induced arthritic (CIA) @entity0 . Male Lewis @entity0 were divided into five groups: healthy control, CIA control, CIA receiving single 0.225  mg  kg(-1) subcutaneous (SC) @entity3 ( @entity6 ), CIA receiving single 2.25  mg  kg(-1) SC @entity6 , and CIA receiving chronic 0.225  mg  kg(-1) SC @entity6 . The CIA @entity0 underwent collagen induction at day 0 and @entity6 was injected at day 21 post-induction. Disease activity was monitored throughout the study and @entity0 were sacrificed at different time points for blood and paw collection. Protein concentrations of @entity4 , @entity1 ligand ( @entity7 ), @entity8 ( @entity8 ), and @entity5 -resistant acid phosphatase 5b (TRACP-5b) in paws were measured by enzyme-linked immunosorbent assays (ELISA). Disease progression and @entity6 pharmacodynamic profiles of @entity4 , @entity1 , @entity7 , and @entity8 were fitted simultaneously and parameters were sequentially applied to fit the TRACP-5b and BMD data. The model was built according to the mechanisms reported in the literature and modeling was performed using ADAPT 5 software with na  ve pooling. Time profiles of @entity4 and @entity1 protein concentrations correlated with their mRNAs. The @entity7 and @entity8 profiles matched previous findings in CIA @entity0 . @entity6 inhibited the expressions of @entity4 , @entity1 , and @entity7 , but did not alter @entity8 . TRACP-5b was also inhibited by @entity6 . Model predictions suggested that anti- @entity4 therapy and anti- @entity7 therapy would result in similar efficacy for prevention of @entity2 among the cytokine antagonists.

title: Modeling effects of XXXX on disease progression of bone mineral density in collagen-induced arthritic @entity0 .

answer: @entity3


abstract: A mechanism-based model was developed to characterize the crosstalk between proinflammatory cytokines, bone remodeling biomarkers, and bone mineral density (BMD) in collagen-induced arthritic (CIA) @entity0 . Male Lewis @entity0 were divided into five groups: healthy control, CIA control, CIA receiving single 0.225  mg  kg(-1) subcutaneous (SC) @entity3 ( @entity6 ), CIA receiving single 2.25  mg  kg(-1) SC @entity6 , and CIA receiving chronic 0.225  mg  kg(-1) SC @entity6 . The CIA @entity0 underwent collagen induction at day 0 and @entity6 was injected at day 21 post-induction. Disease activity was monitored throughout the study and @entity0 were sacrificed at different time points for blood and paw collection. Protein concentrations of @entity4 , @entity1 ligand ( @entity7 ), @entity8 ( @entity8 ), and @entity5 -resistant acid phosphatase 5b (TRACP-5b) in paws were measured by enzyme-linked immunosorbent assays (ELISA). Disease progression and @entity6 pharmacodynamic profiles of @entity4 , @entity1 , @entity7 , and @entity8 were fitted simultaneously and parameters were sequentially applied to fit the TRACP-5b and BMD data. The model was built according to the mechanisms reported in the literature and modeling was performed using ADAPT 5 software with na  ve pooling. Time profiles of @entity4 and @entity1 protein concentrations correlated with their mRNAs. The @entity7 and @entity8 profiles matched previous findings in CIA @entity0 . @entity6 inhibited the expressions of @entity4 , @entity1 , and @entity7 , but did not alter @entity8 . TRACP-5b was also inhibited by @entity6 . Model predictions suggested that anti- @entity4 therapy and anti- @entity7 therapy would result in similar efficacy for prevention of @entity2 among the cytokine antagonists.

title: Modeling effects of @entity3 on disease progression of bone mineral density in collagen-induced arthritic XXXX .

answer: @entity0


abstract: UNASSIGNED: OBJECT Metastatic disease to the craniovertebral junction (CVJ) is rare but presents unique management challenges. To date, studies on using stereotactic radiosurgery (SRS) for CVJ @entity2 have been limited to case reports and small case series. The aim of this analysis was to evaluate the utility of SRS in the management of these secondary lesions. METHODS Clinical and radiological information from the charts of 25 @entity1 with metastatic disease of the CVJ who were treated with SRS between 2005 and 2013 at the Stanford CyberKnife Center were retrospectively reviewed. RESULTS Seven male and 18 female @entity1 with a median age of 58 years (range 34-94 years) were identified. The most common @entity3 were @entity0 (n = 5) and @entity7 (n = 5), and the most frequent symptom was @entity9 (n = 17). The average @entity3 volume treated was 15.9 cm(3) (range 0.16-54.1 cm(3)), with a mean marginal radiation dose of 20.3 Gy (range 15-25.5 Gy). The median follow-up was 18 months (range 1-81 months), though 1 @entity1 was lost to follow-up. SRS provided @entity3 stability in over 80% of @entity1 , offered @entity5 alleviation in nearly two-thirds of @entity1 , and produced no serious complications. Moreover, SRS preserved spinal stability in all but 1 @entity1 , in whom pre-SRS stability was established. There was no evidence of radiation @entity4 in the @entity1 population. Median survival was 28 months (range 2-81 months), with survival of 13.3% at 5 years. CONCLUSIONS In the absence of unstable pathological @entity6 and @entity8 , @entity2 of the CVJ can be safely and effectively treated with SRS. This treatment option offers palliative @entity5 relief and can halt @entity3 progression with only a low risk of complications or spinal instability.

title: Stereotactic radiosurgery for XXXX to the craniovertebral junction preserves spine stability and offers symptomatic relief.

answer: @entity2


abstract: OBJECTIVE: @entity3 ( @entity3 ) has been applied to relieve @entity4 for decades. Recent studies suggested that @entity3 also might alleviate @entity1 , but the most effective stimulation parameters are not known. The objective of this work was to investigate the role of @entity3 frequency in alleviating spike-and-wave (SW) discharges induced in @entity0 by @entity5 ( @entity6 ) infusion. MATERIALS AND METHODS: The SW discharges were induced in nine @entity0 . An epidural electrode was placed in the spinal canal at the cervical level. @entity3 was delivered at four frequencies (30, 80, 130 and 180   Hz) and compared with control intervals without stimulation. The effect was evaluated by analyzing electrocorticographic and intracortical (IC) signals. The means of normalized SW spike power (mSP) and frequency (mSF) were derived from the IC recordings and used to estimate the @entity2 severity. RESULTS: Compared with the control intervals, @entity3 conducted at 30   Hz significantly increased the mSP and mSF indicating an increase of the SW spiking activity; 80   Hz did not induce significant changes of the features. In contrast, 130- and 180-Hz @entity3 reduced both mSP and mSF significantly indicating a reduction of the SW spiking activity. CONCLUSIONS: The present results showed that 130-Hz and 180-Hz @entity3 reduced the SWs power and frequency which may indicate an anticonvulsive effect of these @entity3 frequencies, whereas 30-Hz @entity3 induced the opposite effects and, therefore, may be proconvulsive.

title: The Effect of Spinal Cord Stimulation on XXXX .

answer: @entity1


abstract: UNASSIGNED: PURPOSE OF THE STUDY The aim of the study was to investigate the occurrence of @entity3 ( @entity3 ) of the femoral head following the osteosynthesis of intracapsular @entity1 of the femoral neck in relation to the time interval between injury and surgery and the type of @entity1 . MATERIAL AND METHODS The data of @entity0 with intracapsular @entity1 of the femoral neck surgically treated in the period from 2001 to 2011 were reviewed. Of 1555 @entity0 treated for this @entity1 , 125 (7%) underwent osteosynthesis. The evaluated group included 115 @entity0 who came for examination at one-year follow-up. There were 59 (52%) @entity0 and 56 (48%) @entity0 . Dynamic hip screw (DHS) osteosynthesis with an anti-rotation screw was performed in 103 @entity0 and lag-screw osteosynthesis involving three parallel cannulated cancellous screws was employed in 12 @entity0 . The @entity0 were allocated to groups according to the injury-to-surgery interval and to sub-groups on the basis of the Garden classification of femoral @entity1 stage. RESULTS In the group of 58 @entity0 treated within 6 h of injury, @entity3 developed in 10 (17%). When the type of @entity1 was considered, 4% of the non-displaced @entity1 and 30% of the displaced @entity1 developed @entity3 . The @entity0 with Garden stage I and II (non-displaced) @entity1 treated within 6 h of injury had a significantly lower risk of @entity3 development than those with Garden stage III or IV (displaced) @entity1 . The group treated between 6 and 24 post-injury hours comprised 21 @entity0 , of whom four (19%) had @entity3 . In non-displaced and displaced @entity1 sub-groups, 25% of the @entity0 in the former and 16% in the latter had @entity3 . The stage of displacement had no effect on @entity3 development. The two groups together ( @entity0 treated by 24 h) had a significantly lower @entity3 incidence than the @entity0 treated after 24 h (p = 0.0025). In this group of 36 @entity0 , 16 had @entity3 (44%) and the @entity1 stage made no significant difference (p = 0.6985; nondisplacement sub-group, 41%; displacement sub-group, 55%). CONCLUSIONS The study showed a significantly lower @entity3 occurrence in the @entity0 surgically treated within 24 h of injury. In the @entity0 treated within 6 h of injury, @entity3 incidence was significantly lower in the @entity0 with non-displaced @entity1 , as compared with those who had displaced @entity1 . This was not true for the two @entity0 groups treated later (6-24 and later than 24 h) in which the differences between @entity3 development after non-displaced @entity1 and that after displaced @entity1 were similar. Key words: @entity3 , @entity2 , @entity4 .

title: [Fracture Type and Injury-to-Surgery Interval as Risk Factors for @entity3 of the Femoral Head after Internal Fixation of Intracapsular XXXX ].

answer: @entity2


abstract: UNASSIGNED: PURPOSE OF THE STUDY The aim of the study was to investigate the occurrence of @entity3 ( @entity3 ) of the femoral head following the osteosynthesis of intracapsular @entity1 of the femoral neck in relation to the time interval between injury and surgery and the type of @entity1 . MATERIAL AND METHODS The data of @entity0 with intracapsular @entity1 of the femoral neck surgically treated in the period from 2001 to 2011 were reviewed. Of 1555 @entity0 treated for this @entity1 , 125 (7%) underwent osteosynthesis. The evaluated group included 115 @entity0 who came for examination at one-year follow-up. There were 59 (52%) @entity0 and 56 (48%) @entity0 . Dynamic hip screw (DHS) osteosynthesis with an anti-rotation screw was performed in 103 @entity0 and lag-screw osteosynthesis involving three parallel cannulated cancellous screws was employed in 12 @entity0 . The @entity0 were allocated to groups according to the injury-to-surgery interval and to sub-groups on the basis of the Garden classification of femoral @entity1 stage. RESULTS In the group of 58 @entity0 treated within 6 h of injury, @entity3 developed in 10 (17%). When the type of @entity1 was considered, 4% of the non-displaced @entity1 and 30% of the displaced @entity1 developed @entity3 . The @entity0 with Garden stage I and II (non-displaced) @entity1 treated within 6 h of injury had a significantly lower risk of @entity3 development than those with Garden stage III or IV (displaced) @entity1 . The group treated between 6 and 24 post-injury hours comprised 21 @entity0 , of whom four (19%) had @entity3 . In non-displaced and displaced @entity1 sub-groups, 25% of the @entity0 in the former and 16% in the latter had @entity3 . The stage of displacement had no effect on @entity3 development. The two groups together ( @entity0 treated by 24 h) had a significantly lower @entity3 incidence than the @entity0 treated after 24 h (p = 0.0025). In this group of 36 @entity0 , 16 had @entity3 (44%) and the @entity1 stage made no significant difference (p = 0.6985; nondisplacement sub-group, 41%; displacement sub-group, 55%). CONCLUSIONS The study showed a significantly lower @entity3 occurrence in the @entity0 surgically treated within 24 h of injury. In the @entity0 treated within 6 h of injury, @entity3 incidence was significantly lower in the @entity0 with non-displaced @entity1 , as compared with those who had displaced @entity1 . This was not true for the two @entity0 groups treated later (6-24 and later than 24 h) in which the differences between @entity3 development after non-displaced @entity1 and that after displaced @entity1 were similar. Key words: @entity3 , @entity2 , @entity4 .

title: [Fracture Type and Injury-to-Surgery Interval as Risk Factors for XXXX of the Femoral Head after Internal Fixation of Intracapsular @entity2 ].

answer: @entity3


abstract: STUDY DESIGN: Retrospective database analysis. OBJECTIVE: A range of @entity0 -reported outcomes were used to measure disability due to @entity5 . There is not a single @entity2 disability measurement commonly used in all randomized controlled trials. We report here our assessment as to whether different disability measures are sufficiently comparable to allow data pooling across trials. SUMMARY OF BACKGROUND DATA: We used individual @entity0 data from a repository of data from @entity2 trials of therapist-delivered interventions. METHODS: We used data from 11 trials (n = 6089 @entity0 ) that had at least 2 of the following 7 measurements: Roland-Morris Disability Questionnaire, @entity4 Grade disability score, Physical Component Summary of the 12- or 36-Item Short Form Health Survey, @entity0 Specific Functional Scale, @entity1 Disability Index, @entity3 Index, and Hannover Functional Ability Questionnaire. Within each trial, the change score between baseline and short-term follow-up was computed for each outcome and this was used to calculate the correlation between the change scores and the Cohen's k for the 3-level outcome of change score of less than, equal to, and more than zero. It was considered feasible to pool 2 measures if they were at least moderately correlated (correlation >0.5) and have at least moderately similar responsiveness (k > 0.4). RESULTS: Although all pairs of measures were found to be positively correlated, most correlations were less than 0.5, with only 1 pair of outcomes in 1 trial having a correlation of more than 0.6. All k statistics were less than 0.4 so that in no cases were the criteria for acceptability of pooling measures satisfied. CONCLUSION: The lack of agreement between different outcome measures means that pooling of data on these different disability measurements in a meta-analysis is not recommended. LEVEL OF EVIDENCE: 2.

title: Can We Convert Between Outcome Measures of Disability for XXXX ?

answer: @entity5


abstract: BACKGROUND: Recent evidence suggests a link between the magnitude and distribution of hemodynamic factors and the formation and rupture of @entity0 . However, there are many conflicting results. OBJECTIVE: To quantify the effect of hemodynamic factors on @entity1 formation and their association with @entity3 . METHODS: We performed a systematic review and meta-analysis through October 2014. Analysis of the effects of hemodynamic factors on @entity1 formation was performed by pooling the results of studies that compared geometrical models of @entity0 " models where the @entity1 was artificially removed. Furthermore, we calculated pooled standardized mean differences between ruptured and unruptured @entity1 to quantify the association of hemodynamic factors with @entity3 . Standard PRISMA guidelines were followed. RESULTS: The hemodynamic factors that showed high positive correlations with location of @entity1 formation were high @entity2 ( @entity2 ) and high gradient oscillatory number, with pooled proportions of 78.8% and 85.7%, respectively. Positive correlations were largely seen in bifurcation @entity1 , whereas negative correlations were seen in sidewall @entity1 . Mean and normalized @entity2 were significantly lower and low shear area significantly higher in @entity3 . CONCLUSION: Pooled analyses of computational fluid dynamics models suggest that an increase in @entity2 and gradient oscillatory number may contribute to @entity1 formation, whereas low @entity2 is associated with @entity3 . The location of the @entity1 at the bifurcation or sidewall may influence the correlation of these hemodynamic factors. ABBREVIATIONS: AFI, @entity1 formation indexCFD, computational fluid dynamicsGON, gradient oscillatory numberIA, intracranial aneurysmLSA, low shear indexOSI, oscillatory shear indexSD, standard deviationSMD, standardized mean differenceSWSSG, spatial @entity2 gradientWSS, @entity2 .

title: Association of Hemodynamic Factors With XXXX Formation and Rupture: Systematic Review and Meta-analysis.

answer: @entity0


abstract: BACKGROUND: Posterior cervical fusion with @entity7 ( @entity7 ) is a novel allograft technology offering the potential to provide indirect neuroforaminal decompression while simultaneously enhancing fusion by placing the allograft in compression. OBJECTIVE: To analyze the clinical and radiological outcomes after posterior cervical fusion with @entity7 in @entity0 with symptomatic anterior cervical @entity5 . METHODS: Medical records of @entity0 who underwent posterior cervical fusion with @entity7 for symptomatic @entity5 after anterior cervical diskectomy and fusion were reviewed. Standardized outcome measures such as @entity2 ( @entity2 ) score for neck and arm @entity1 , @entity3 ( @entity3 ), and upright lateral cervical radiographs were reviewed. RESULTS: There were 19 @entity0 with symptomatic cervical @entity5 . Preoperative symptoms included @entity8 . The average follow-up was 20 months (range, 12-56 months). There was improvement in @entity2 score for neck @entity1 (P < .004), radicular arm @entity1 (P < .007), and @entity3 score (P < .06) after surgery, with 83%, 72%, and 67% of @entity0 showing improvement in their @entity2 neck @entity1 , @entity2 arm @entity1 , and @entity3 scores, respectively. Fusion rate was high, with fusion occurring at all levels treated for @entity5 . There was a small improvement in cervical @entity4 (mean difference, 2    5.17  ; P = .09) and slight worsening of C2-7 sagittal vertical axis after surgery (mean difference, 1.89    7.87 mm; P = .43). CONCLUSION: @entity7 provides an important fusion technique, allowing placement of an allograft in compression for posterior cervical fusion in @entity0 with anterior cervical @entity5 . Although there was improvement in clinical outcome measures after surgery, placement of @entity7 had no clinically significant impact on cervical @entity6 . ABBREVIATIONS: ACDF, anterior cervical diskectomy and fusionCIS, cervical interfacet spacerICBG, iliac crest bone graftNDI, @entity3 IndexSVA, sagittal vertical axisVAS, @entity2 .

title: Posterior Cervical Fusion Using Cervical Interfacet Spacers in @entity0 With Symptomatic Cervical XXXX .

answer: @entity5


abstract: BACKGROUND: Posterior cervical fusion with @entity7 ( @entity7 ) is a novel allograft technology offering the potential to provide indirect neuroforaminal decompression while simultaneously enhancing fusion by placing the allograft in compression. OBJECTIVE: To analyze the clinical and radiological outcomes after posterior cervical fusion with @entity7 in @entity0 with symptomatic anterior cervical @entity5 . METHODS: Medical records of @entity0 who underwent posterior cervical fusion with @entity7 for symptomatic @entity5 after anterior cervical diskectomy and fusion were reviewed. Standardized outcome measures such as @entity2 ( @entity2 ) score for neck and arm @entity1 , @entity3 ( @entity3 ), and upright lateral cervical radiographs were reviewed. RESULTS: There were 19 @entity0 with symptomatic cervical @entity5 . Preoperative symptoms included @entity8 . The average follow-up was 20 months (range, 12-56 months). There was improvement in @entity2 score for neck @entity1 (P < .004), radicular arm @entity1 (P < .007), and @entity3 score (P < .06) after surgery, with 83%, 72%, and 67% of @entity0 showing improvement in their @entity2 neck @entity1 , @entity2 arm @entity1 , and @entity3 scores, respectively. Fusion rate was high, with fusion occurring at all levels treated for @entity5 . There was a small improvement in cervical @entity4 (mean difference, 2    5.17  ; P = .09) and slight worsening of C2-7 sagittal vertical axis after surgery (mean difference, 1.89    7.87 mm; P = .43). CONCLUSION: @entity7 provides an important fusion technique, allowing placement of an allograft in compression for posterior cervical fusion in @entity0 with anterior cervical @entity5 . Although there was improvement in clinical outcome measures after surgery, placement of @entity7 had no clinically significant impact on cervical @entity6 . ABBREVIATIONS: ACDF, anterior cervical diskectomy and fusionCIS, cervical interfacet spacerICBG, iliac crest bone graftNDI, @entity3 IndexSVA, sagittal vertical axisVAS, @entity2 .

title: Posterior Cervical Fusion Using Cervical Interfacet Spacers in XXXX With Symptomatic Cervical @entity5 .

answer: @entity0


abstract: UNASSIGNED: @entity0 stem cells (BCSCs) have the greatest potential to maintain tumorigenesis in all subtypes of @entity1 cells and were regarded as the key drivers of @entity1 . Recent evidence has demonstrated that BCSCs contributed to a high degree of resistance to therapy. However, how BCSCs self renewal and tumorigenicity are maintained remains obscure. Herein, our study illustrated that overexpression of let-7a reduced cell proliferation and mammosphere formation ability of @entity0 stem cells(BCSCs) in a @entity2 -dependent manner through different pathways in vitro and in vivo. To be specific, we provided the evidence that let-7a was decreased, and reversely the expression of @entity2 was increased with moderate expression in early stages (I/II) and high expression in advanced stages (III/IV) in @entity0 specimens. In addition, the negative correlation between let-7a and @entity2 was clearly observed. In vitro, we found that let-7a inhibited mammosphere-forming efficiency and the mammosphere-size via NF-kB and MAPK/ @entity3 pathway. The inhibitory effect of let-7a on mammosphere formation efficiency and the size of mammospheres was abolished after the depletion of @entity2 . On the contrary, enforced expression of @entity2 rescued the effect of let-7a. In vivo, let-7a inhibited the growth of @entity1 , whereas the negative effect of let-7a was rescued after overexpressing @entity2 . Taken together, our findings suggest that let-7a played a @entity1 suppressive role in a @entity2 -dependent manner.

title: Let-7a regulates mammosphere formation capacity through Ras/NF-kB and Ras/MAPK/ @entity3 pathway in XXXX stem cells.

answer: @entity0


abstract: UNASSIGNED: @entity0 stem cells (BCSCs) have the greatest potential to maintain tumorigenesis in all subtypes of @entity1 cells and were regarded as the key drivers of @entity1 . Recent evidence has demonstrated that BCSCs contributed to a high degree of resistance to therapy. However, how BCSCs self renewal and tumorigenicity are maintained remains obscure. Herein, our study illustrated that overexpression of let-7a reduced cell proliferation and mammosphere formation ability of @entity0 stem cells(BCSCs) in a @entity2 -dependent manner through different pathways in vitro and in vivo. To be specific, we provided the evidence that let-7a was decreased, and reversely the expression of @entity2 was increased with moderate expression in early stages (I/II) and high expression in advanced stages (III/IV) in @entity0 specimens. In addition, the negative correlation between let-7a and @entity2 was clearly observed. In vitro, we found that let-7a inhibited mammosphere-forming efficiency and the mammosphere-size via NF-kB and MAPK/ @entity3 pathway. The inhibitory effect of let-7a on mammosphere formation efficiency and the size of mammospheres was abolished after the depletion of @entity2 . On the contrary, enforced expression of @entity2 rescued the effect of let-7a. In vivo, let-7a inhibited the growth of @entity1 , whereas the negative effect of let-7a was rescued after overexpressing @entity2 . Taken together, our findings suggest that let-7a played a @entity1 suppressive role in a @entity2 -dependent manner.

title: Let-7a regulates mammosphere formation capacity through Ras/NF-kB and Ras/MAPK/ XXXX pathway in @entity0 stem cells.

answer: @entity3


abstract: OBJECTIVES: To investigate the development of post-extraction @entity1 (PEB) after the prophylactic use of @entity2 (CHX). @entity0 AND METHODS: A total of 201 @entity0 who underwent a tooth extraction were randomly distributed into four groups: 52 received no prophylaxis (CONTROL), 50 did a mouthwash with 0.2% CHX before the tooth extraction (CHX-MW), 51 did a mouthwash with 0.2% CHX and a subgingival irrigation with 1% CHX (CHX-MW/SUB_IR) and 48 did a mouthwash with 0.2% CHX and a continuous supragingival irrigation with 1% CHX (CHX-MW/SUPRA_IR). Peripheral venous blood samples were collected at baseline, 30 seconds after performing the mouthwash and the subgingival or supragingival irrigation, and at 30 seconds and 15 minutes after completion of the tooth extraction. Blood samples were analysed applying conventional microbiological cultures under aerobic and anaerobic conditions performing bacterial identification of the isolates. RESULTS: The prevalences of PEB in the CONTROL, CHX-MW, CHX-MW/SUB_IR and CHX-MWSUPRA_IR groups were 52%, 50%, 55% and 50%, respectively, at 30 seconds and 23%, 4%, 10% and 27%, respectively, at 15 minutes. The prevalence of PEB at 15 minutes was significantly higher in the CONTROL group than in the CHX-MW group (23% versus 4%; p = 0.005). At the same time, no differences were found between CONTROL group and CHX-MW/SUB_IR or CHX-MW/SUPRA_IR groups. Streptococci (mostly viridans group streptococci) were the most frequently identified bacteria (69-79%). CONCLUSIONS: Performing a 0.2% CHX mouthwash significantly reduces the duration of PEB. Subgingival irrigation with 1% CHX didn't increase the efficacy of the mouthwash while supragingival irrigation even decreased this efficacy, probably due to the influence of these maneuvers on the onset of @entity1 . CLINICAL RELEVANCE: These results confirm the suitability of performing a mouthwash with 0.2% CHX before tooth extractions in order to reduce the duration of PEB. This practice should perhaps be extended to all dental manipulations. TRIAL REGISTRATION: Clinicaltrials.gov NCT02150031.

title: Post-tooth extraction @entity1 : a randomized clinical trial on the efficacy of XXXX prophylaxis.

answer: @entity2


abstract: OBJECTIVES: To investigate the development of post-extraction @entity1 (PEB) after the prophylactic use of @entity2 (CHX). @entity0 AND METHODS: A total of 201 @entity0 who underwent a tooth extraction were randomly distributed into four groups: 52 received no prophylaxis (CONTROL), 50 did a mouthwash with 0.2% CHX before the tooth extraction (CHX-MW), 51 did a mouthwash with 0.2% CHX and a subgingival irrigation with 1% CHX (CHX-MW/SUB_IR) and 48 did a mouthwash with 0.2% CHX and a continuous supragingival irrigation with 1% CHX (CHX-MW/SUPRA_IR). Peripheral venous blood samples were collected at baseline, 30 seconds after performing the mouthwash and the subgingival or supragingival irrigation, and at 30 seconds and 15 minutes after completion of the tooth extraction. Blood samples were analysed applying conventional microbiological cultures under aerobic and anaerobic conditions performing bacterial identification of the isolates. RESULTS: The prevalences of PEB in the CONTROL, CHX-MW, CHX-MW/SUB_IR and CHX-MWSUPRA_IR groups were 52%, 50%, 55% and 50%, respectively, at 30 seconds and 23%, 4%, 10% and 27%, respectively, at 15 minutes. The prevalence of PEB at 15 minutes was significantly higher in the CONTROL group than in the CHX-MW group (23% versus 4%; p = 0.005). At the same time, no differences were found between CONTROL group and CHX-MW/SUB_IR or CHX-MW/SUPRA_IR groups. Streptococci (mostly viridans group streptococci) were the most frequently identified bacteria (69-79%). CONCLUSIONS: Performing a 0.2% CHX mouthwash significantly reduces the duration of PEB. Subgingival irrigation with 1% CHX didn't increase the efficacy of the mouthwash while supragingival irrigation even decreased this efficacy, probably due to the influence of these maneuvers on the onset of @entity1 . CLINICAL RELEVANCE: These results confirm the suitability of performing a mouthwash with 0.2% CHX before tooth extractions in order to reduce the duration of PEB. This practice should perhaps be extended to all dental manipulations. TRIAL REGISTRATION: Clinicaltrials.gov NCT02150031.

title: Post-tooth extraction XXXX : a randomized clinical trial on the efficacy of @entity2 prophylaxis.

answer: @entity1


abstract: UNASSIGNED: Fatigue is a symptom of @entity2 that causes difficulty at work. An improved understanding of this symptom could assist its management in the work environment. The aim of this study was to explore @entity0 with @entity3 ' experiences of @entity4 in work. A qualitative descriptive design was used with semi-structured interviews and a constant comparative method of data analysis. There were 18 @entity0 , the majority of them female with @entity1 ( @entity1 ) and working full-time. Three themes were identified: "Impact of @entity4 on work performance" with cognition, mood and physical abilities being the main difficulties reported. In the second theme "Disclosure at Work" @entity0 discussed disclosing their disease to employers but reported a lack of understanding of @entity4 from colleagues. The final theme "work-based @entity4 management strategies" included cognitive strategies and energy management techniques, which were mainly self-taught. In this study, @entity4 was reported to impact on many areas of work performance with limited understanding from colleagues and employers. Interventions from health professionals to assist with development of work-related self-management skills are required to assist with symptom management in the work place. Such interventions should include education to employers and colleagues on the nature of @entity4 in @entity3 .

title: Impact of Fatigue in XXXX in the Work Environment: A Qualitative Study.

answer: @entity3


abstract: BACKGROUND: Superparamagnetic @entity6 Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example @entity8 ( @entity5 ), is needed to stabilize the SPION and prevent aggregation. As the particles are foreign to the body, reaction against the SPION could occur. In this study we investigated the effects that SPION may have on experimental @entity4 after intra-articular (i.a.) or intravenous (i.v.) injection. METHODS: @entity5 -coated SPION were injected either i.a. (6 or 24  g @entity2 ) or i.v. (100  g or 1 mg @entity2 ) into na  ve @entity7 deficient ( @entity7 -/-) or wild-type C57Bl/6 @entity0 , or C57Bl/6 mice with antigen-induced @entity4 . As control, some @entity0 were injected with @entity5 or PBS. MR imaging was performed at 1 and 7 days after injection. @entity0 were sacrificed 2 hours and 1, 2, 7, 10 and 14 days after injection of the SPION, and RNA from synovium and liver was isolated for pro-inflammatory gene expression analysis. Serum cytokine measurements and whole knee joint histology were also performed. RESULTS: Injection of a high dose of SPION or @entity5 into na  ve knee joints resulted in an immediate upregulation of pro-inflammatory gene expression in the synovium. A similar gene expression profile was observed after SPION or @entity5 injection into knee joints of @entity7 -/- @entity0 , indicating that this effect is not due to @entity3 contamination. Histological analysis of the knee joints also revealed @entity1 after SPION injection. Two hours after i.v. injection of SPION or @entity5 into na  ve @entity0 , an upregulation of pro-inflammatory gene expression was detected in the liver. Administration of SPION or @entity5 into arthritic @entity0 via i.a. injection did not result in an upregulation in gene expression and also no additional effects were observed on histology. MR imaging and histology showed long-term retention of SPION in the inflamed joint. However, 14 days after the injections no long-term effects were evident for gene expression, histology or serum cytokine concentrations. CONCLUSIONS: Injection of SPION, either locally or systemically, gives an acute inflammatory response. In the long term, up to 14 days after the injection, while the SPION reside in the joint, no further activating effects of SPION were observed. Hence, we conclude that SPION do not aggravate @entity4 and can therefore be used safely to detect joint @entity1 by MR imaging.

title: The In-Vivo Use of Superparamagnetic @entity6 Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental XXXX .

answer: @entity4


abstract: BACKGROUND: Superparamagnetic @entity6 Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example @entity8 ( @entity5 ), is needed to stabilize the SPION and prevent aggregation. As the particles are foreign to the body, reaction against the SPION could occur. In this study we investigated the effects that SPION may have on experimental @entity4 after intra-articular (i.a.) or intravenous (i.v.) injection. METHODS: @entity5 -coated SPION were injected either i.a. (6 or 24  g @entity2 ) or i.v. (100  g or 1 mg @entity2 ) into na  ve @entity7 deficient ( @entity7 -/-) or wild-type C57Bl/6 @entity0 , or C57Bl/6 mice with antigen-induced @entity4 . As control, some @entity0 were injected with @entity5 or PBS. MR imaging was performed at 1 and 7 days after injection. @entity0 were sacrificed 2 hours and 1, 2, 7, 10 and 14 days after injection of the SPION, and RNA from synovium and liver was isolated for pro-inflammatory gene expression analysis. Serum cytokine measurements and whole knee joint histology were also performed. RESULTS: Injection of a high dose of SPION or @entity5 into na  ve knee joints resulted in an immediate upregulation of pro-inflammatory gene expression in the synovium. A similar gene expression profile was observed after SPION or @entity5 injection into knee joints of @entity7 -/- @entity0 , indicating that this effect is not due to @entity3 contamination. Histological analysis of the knee joints also revealed @entity1 after SPION injection. Two hours after i.v. injection of SPION or @entity5 into na  ve @entity0 , an upregulation of pro-inflammatory gene expression was detected in the liver. Administration of SPION or @entity5 into arthritic @entity0 via i.a. injection did not result in an upregulation in gene expression and also no additional effects were observed on histology. MR imaging and histology showed long-term retention of SPION in the inflamed joint. However, 14 days after the injections no long-term effects were evident for gene expression, histology or serum cytokine concentrations. CONCLUSIONS: Injection of SPION, either locally or systemically, gives an acute inflammatory response. In the long term, up to 14 days after the injection, while the SPION reside in the joint, no further activating effects of SPION were observed. Hence, we conclude that SPION do not aggravate @entity4 and can therefore be used safely to detect joint @entity1 by MR imaging.

title: The In-Vivo Use of Superparamagnetic XXXX Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental @entity4 .

answer: @entity6


abstract: UNASSIGNED: @entity4 ( @entity4 ) is the most common form of @entity5 . The most frequent pathologic finding in this condition is @entity1 ( @entity1 ). In addition, in a small proportion (14-23%) of refractory @entity4 @entity0 , the presence of @entity1 is bilateral. @entity4 involves grey matter (GM) and white matter (WM) abnormalities in a wide cortico-subcortical network. However, the impact of @entity3 on specific WM fiber pathways and associated functional systems as well as @entity2 propagation pathways remains unclear. There is still much controversy regarding the role of the commissures (corpus callosum, hippocampal commissure and anterior commissure) in interhemispheric @entity2 propagation. This study aimed to investigate the integrity of WM interhemispheric connectivity in a singular sample of @entity0 with @entity4 and bilateral @entity1 using structural magnetic resonance imaging (MRI). We performed multimodal structural MRI [high resolution T1-weighted and diffusion tensor imaging (DTI)] analyses of seven @entity0 with medically refractory @entity4 with bilateral @entity1 , fourteen unilateral left @entity4 @entity0 and fifteen matched healthy individuals. Whole-brain voxel-wise analysis techniques were used. These @entity0 evidenced WM derangement [reduced fractional anisotropy (FA), increased @entity6 ( @entity6 ) or reduced WM volume] in temporal and extratemporal tracks, but also in commissural pathways, compared to the unilateral left @entity4 @entity0 and the control group. Presence of reduced FA or increased @entity6 in the fornix, cingulum and uncinate fasciculus in addition to reduced WM volume in the fornix was also encountered. Neuropsychological assessment was performed without significant correlations with structural data. The current results support the idea that commissural pathways play a contributory role in interhemispheric @entity4 @entity2 propagation in bilateral @entity1 and offer new perspectives about the long-term effects on interhemispheric connectivity associated with @entity2 propagation patterns in @entity4 @entity0 .

title: Interhemispheric microstructural connectivity in bitemporal lobe epilepsy with XXXX .

answer: @entity1


abstract: UNASSIGNED: Logopenic progressive @entity3 is one of the clinical presentations of primary progressive @entity3 and formally defined by the co-occurrence of impaired naming and sentence repetition. Impaired naming is attributed to failure of lexical retrieval, which is a multi-staged process subserved by anatomically segregated brain regions. By dissecting the neurocognitive processes involved in impaired naming, we aimed to disentangle the clinical and neuroanatomical heterogeneity of this syndrome. Twenty-one individuals (66.7% females, age range 53-83 years) who fulfilled diagnostic criteria for logopenic variant and had at least two clinical and language assessments, 1 year apart, were recruited and matched for age, sex distribution and level of education with a healthy control sample (n  =  18). All @entity0 underwent a structural brain scan at the first visit and surface-wise statistical analysis using Freesurfer. Seventeen @entity0 with logopenic variant underwent amyloid imaging, with 14 demonstrating high amyloid retention. Based on their performance on single-word comprehension, repetition and confrontation naming, three subgroups of logopenic cases with distinctive linguistic profiles and distribution of @entity2 were identified. The first subgroup (n  =  10) demonstrated @entity5 and left-sided @entity2 in the posterior inferior parietal lobule and lateral temporal cortex. The second subgroup (n  =  6), presented additional mild @entity1 , and also exhibited bilateral thinning of the fusiform gyri. The third subgroup (n  =  5) showed additional @entity4 , and cortical thinning focused on the left superior temporal gyrus. The subgroups differed in the proportion of cases with high amyloid retention and in the rate of decline of naming performance over time, suggesting that neurodegeneration spreads differentially throughout regions subserving word processing. In line with previous reports, these results confirm the extensive damage to the language network and, in part, explain the clinical heterogeneity observed across logopenic cases.

title: Is the logopenic-variant of primary progressive XXXX a unitary disorder?

answer: @entity3


abstract: BACKGROUND: Immunological disturbances are hypothesised to play a role in @entity1 ( @entity1 ) and therefore intravenous immunoglubulins (IVIg) have been tested in @entity1 @entity0 . OBJECTIVES: The objectives were to investigate the benefits and harms of IVIg versus placebo, no intervention, or treatment as usual in @entity0 with @entity1 . SEARCH STRATEGY: We searched the published literature in all relevant databases. SELECTION CRITERIA: Randomised trials investigating IVIg versus placebo, no intervention, or treatment as usual in @entity0 with @entity1 . DATA COLLECTION AND ANALYSIS: We undertook meta-analyses of aggregated data and individual @entity0 data using a two-step approach, and we conducted bias domain assessments and trial sequential analyses to assess the risks of systematic and random errors. MAIN RESULTS: We identified 11 randomised clinical trials. No significant difference in the frequency of no live birth was found when IVIg was compared with placebo or treatment as usual (RR 0.92, 95% CI 0.75-1.12, p = 0.42). Trial sequential analysis showed that the required information size of 1,008 @entity0 was not obtained. IVIg compared with placebo seems to increase the risk of adverse events. Subgroup analysis suggests that @entity0 with @entity1 after a birth (secondary @entity1 ) seemed most likely to obtain a potential beneficial effect of IVIg (RR for no live birth 0.77, 95%CI 0.58-1.02, p = 0.06), however, trial sequential analysis showed that insufficient information is presently accrued. CONCLUSION: We cannot recommend or refute IVIg in @entity0 with @entity1 . IVIg should therefore be assessed in further randomised clinical trials with positive outcomes before any clinical use is considered.

title: The Effects of Intravenous Immunoglobulins in XXXX with Recurrent Miscarriages: A Systematic Review of Randomised Trials with Meta-Analyses and Trial Sequential Analyses Including Individual @entity0 Data.

answer: @entity0


abstract: BACKGROUND: Immunological disturbances are hypothesised to play a role in @entity1 ( @entity1 ) and therefore intravenous immunoglubulins (IVIg) have been tested in @entity1 @entity0 . OBJECTIVES: The objectives were to investigate the benefits and harms of IVIg versus placebo, no intervention, or treatment as usual in @entity0 with @entity1 . SEARCH STRATEGY: We searched the published literature in all relevant databases. SELECTION CRITERIA: Randomised trials investigating IVIg versus placebo, no intervention, or treatment as usual in @entity0 with @entity1 . DATA COLLECTION AND ANALYSIS: We undertook meta-analyses of aggregated data and individual @entity0 data using a two-step approach, and we conducted bias domain assessments and trial sequential analyses to assess the risks of systematic and random errors. MAIN RESULTS: We identified 11 randomised clinical trials. No significant difference in the frequency of no live birth was found when IVIg was compared with placebo or treatment as usual (RR 0.92, 95% CI 0.75-1.12, p = 0.42). Trial sequential analysis showed that the required information size of 1,008 @entity0 was not obtained. IVIg compared with placebo seems to increase the risk of adverse events. Subgroup analysis suggests that @entity0 with @entity1 after a birth (secondary @entity1 ) seemed most likely to obtain a potential beneficial effect of IVIg (RR for no live birth 0.77, 95%CI 0.58-1.02, p = 0.06), however, trial sequential analysis showed that insufficient information is presently accrued. CONCLUSION: We cannot recommend or refute IVIg in @entity0 with @entity1 . IVIg should therefore be assessed in further randomised clinical trials with positive outcomes before any clinical use is considered.

title: The Effects of Intravenous Immunoglobulins in @entity0 with Recurrent Miscarriages: A Systematic Review of Randomised Trials with Meta-Analyses and Trial Sequential Analyses Including Individual XXXX Data.

answer: @entity0


abstract: PURPOSE: The objective of this study was to assess the psychometric properties of the @entity1 Impact Scale (SIS). METHODS: Data was derived from a study assessing a community-based @entity1 rehabilitation program. @entity0 were administered the SIS and Euroqol-5D (EQ-5D-5L) on admission to the study, and at six month and 12 month follow-up. The psychometric performance of each domain of the SIS was assessed at each time point. RESULTS: A total of 164 @entity0 completed outcome measures at baseline, 108 @entity0 at six months and 37 @entity0 at 12 months. Correlation of the SIS domains with the EQ-5D-5L suggested that the dimensions of health contributing to a @entity0 's perception of health-related quality of life changes over time. CONCLUSION: The SIS performed well in a sample of @entity0 undergoing @entity1 rehabilitation in the community. Our findings suggest that the multidimensionality of the SIS may allow health professionals to track @entity0 progress and tailor rehabilitation interventions to target the dimensions of health that are most important to a @entity0 's overall health and perceived quality of life over time. Implications for Rehabilitation There is an increased need for valid and reliable measures to evaluate the outcomes of @entity0 recovering from @entity1 in the community. The @entity1 Impact Scale (SIS) measures multiple domains of health and is well-suited for use in @entity0 recovering from @entity1 in the community. There is a high level of internal consistency in the eight SIS domains with no evidence of floor effects; ceiling effects were noted for several domains. Correlation of the SIS with the Euroqol-5D suggested that the dimensions of health contributing to a @entity0 's perception of health related quality of life changes over time.

title: The XXXX impact scale: performance as a quality of life measure in a community-based @entity1 rehabilitation setting.

answer: @entity1