abstract: Problems with determining @entity1 to @entity4 , @entity5 , and @entity2 with intradermal skin tests and patch tests are reported in three @entity0 . Three @entity0 were tested with intradermal injections of 0.9% @entity3 , 1% @entity4 , 1% @entity5 , and 0.5% @entity2 following apparent @entity1 to @entity4 . Patch testing using hydrophilic ointment base, 1% @entity4 , 1% @entity5 , and 0.5% @entity2 was also done. All three @entity0 had no reaction to intradermal @entity3 or @entity2 ; all patch tests were negative. The first @entity0 reacted to @entity5 strongly and to @entity4 more weakly; punch biopsy of the @entity5 reaction site showed a direct toxic effect with no allergic component. Punch biopsy of the @entity4 site showed a typical @entity1 . Two concentrations (0.5% and 1.0%) of @entity5 injection were used to test the second @entity0 , and he reacted to both concentrations but not to any other injections. His positive reactions contained blisters rather than the typical wheal-and-flare reaction of @entity1 . The third @entity0 had similar responses including reactions to 0.5% and 0.1% @entity5 (he was not tested with 1% @entity5 ). Skin testing may be of value in predicting @entity4 or @entity5 allergy, but the nonspecific toxic effect of @entity5 makes interpretation difficult.

title: Allergy to XXXX : lack of predictability by skin testing.

answer: @entity4


abstract: RATIONALE AND OBJECTIVES: Most secondary intramammary @entity2 occur as metastatic involvement from the contralateral breast. Breast @entity1 (BM) from nonmammary @entity2 are very rare. The aims of this study were to estimate retrospectively the prevalence of BM from nonmammary @entity2 and to describe their radiologic appearance. MATERIALS AND METHODS: BM were identified in 51 @entity0 , including 43 @entity0 and eight @entity0 with a median age of 61 years (range, 24-84 years). Computed tomography of the thoracic region identified 108 lesions in 38 @entity0 . Mammography was available for 37 @entity0 (54 lesions). Ultrasound evaluation was performed in 43 @entity0 (71 lesions). In 24 @entity0 (93 lesions), magnetic resonance imaging of the breast was done. Images were reviewed in consensus by two radiologists according to the Breast Imaging Reporting and Data System lexicon. RESULTS: The prevalence of BM in several @entity2 ranged from 0.12% to 4.92%. On computed tomography, most @entity1 were round or oval in shape with marked or moderate enhancement. On mammography, solitary or multiple round or oval masses with circumscribed margins were the most common pattern of BM. Ten percent showed microcalcifications. On ultrasound, most BM were hypoechoic, oval or round in shape, with microlobulated or circumscribed margins, and posterior acoustic enhancement. Doppler imaging showed hypervascularity in 39% of BM. On magnetic resonance imaging, most lesions demonstrated marked homogenous contrast enhancement. Type 1 kinetic curve was seen in 18%, type 2 in 52%, and type 3 in 30%. CONCLUSIONS: The radiologic features reported in this study should be taken into consideration in the differential diagnosis of @entity3 .

title: XXXX to the breast from non-mammary @entity2 : @entity2 , prevalence, clinical signs, and radiological features.

answer: @entity1


abstract: RATIONALE AND OBJECTIVES: Most secondary intramammary @entity2 occur as metastatic involvement from the contralateral breast. Breast @entity1 (BM) from nonmammary @entity2 are very rare. The aims of this study were to estimate retrospectively the prevalence of BM from nonmammary @entity2 and to describe their radiologic appearance. MATERIALS AND METHODS: BM were identified in 51 @entity0 , including 43 @entity0 and eight @entity0 with a median age of 61 years (range, 24-84 years). Computed tomography of the thoracic region identified 108 lesions in 38 @entity0 . Mammography was available for 37 @entity0 (54 lesions). Ultrasound evaluation was performed in 43 @entity0 (71 lesions). In 24 @entity0 (93 lesions), magnetic resonance imaging of the breast was done. Images were reviewed in consensus by two radiologists according to the Breast Imaging Reporting and Data System lexicon. RESULTS: The prevalence of BM in several @entity2 ranged from 0.12% to 4.92%. On computed tomography, most @entity1 were round or oval in shape with marked or moderate enhancement. On mammography, solitary or multiple round or oval masses with circumscribed margins were the most common pattern of BM. Ten percent showed microcalcifications. On ultrasound, most BM were hypoechoic, oval or round in shape, with microlobulated or circumscribed margins, and posterior acoustic enhancement. Doppler imaging showed hypervascularity in 39% of BM. On magnetic resonance imaging, most lesions demonstrated marked homogenous contrast enhancement. Type 1 kinetic curve was seen in 18%, type 2 in 52%, and type 3 in 30%. CONCLUSIONS: The radiologic features reported in this study should be taken into consideration in the differential diagnosis of @entity3 .

title: @entity1 to the breast from non-mammary XXXX : @entity2 , prevalence, clinical signs, and radiological features.

answer: @entity2


abstract: RATIONALE AND OBJECTIVES: Most secondary intramammary @entity2 occur as metastatic involvement from the contralateral breast. Breast @entity1 (BM) from nonmammary @entity2 are very rare. The aims of this study were to estimate retrospectively the prevalence of BM from nonmammary @entity2 and to describe their radiologic appearance. MATERIALS AND METHODS: BM were identified in 51 @entity0 , including 43 @entity0 and eight @entity0 with a median age of 61 years (range, 24-84 years). Computed tomography of the thoracic region identified 108 lesions in 38 @entity0 . Mammography was available for 37 @entity0 (54 lesions). Ultrasound evaluation was performed in 43 @entity0 (71 lesions). In 24 @entity0 (93 lesions), magnetic resonance imaging of the breast was done. Images were reviewed in consensus by two radiologists according to the Breast Imaging Reporting and Data System lexicon. RESULTS: The prevalence of BM in several @entity2 ranged from 0.12% to 4.92%. On computed tomography, most @entity1 were round or oval in shape with marked or moderate enhancement. On mammography, solitary or multiple round or oval masses with circumscribed margins were the most common pattern of BM. Ten percent showed microcalcifications. On ultrasound, most BM were hypoechoic, oval or round in shape, with microlobulated or circumscribed margins, and posterior acoustic enhancement. Doppler imaging showed hypervascularity in 39% of BM. On magnetic resonance imaging, most lesions demonstrated marked homogenous contrast enhancement. Type 1 kinetic curve was seen in 18%, type 2 in 52%, and type 3 in 30%. CONCLUSIONS: The radiologic features reported in this study should be taken into consideration in the differential diagnosis of @entity3 .

title: @entity1 to the breast from non-mammary @entity2 : XXXX , prevalence, clinical signs, and radiological features.

answer: @entity2


abstract: BACKGROUND: @entity2 , @entity1 , increasing age, and smoking are known risk factors for @entity3 . Prevalence of @entity3 is high in South Asians. However, ethnic subgroup differences and determinants of @entity3 within the South Asian population have not been explored. METHODS: The National Health Survey of Pakistan conducted between 1990 and 1994 was used to explore ethnic subgroup variation in @entity3 . Distinct ethnic subgroups, the Muhajir, the Punjabi, the Sindhi, the Pashtun, and the Baluchi, were defined by mother tongue. We report results in individuals aged >or=15 years (N = 9442). @entity3 was defined as dipstick positive for protein on random urine sample. RESULTS: Increasing age, high consumption of meat, and presence of @entity2 and @entity1 were each independently associated with @entity3 . The age-standardized prevalence of @entity3 was 4.6% (4.2% to 5.1%) and varied among ethnic subgroups (P < 0.001). The highest was among the Sindhi ( @entity0 9.5%, @entity0 10.3%), then the Muhajir ( @entity0 8.2%, @entity0 4.7%), the Punjabi ( @entity0 3.2% @entity0 3.5%), and lowest among the Baluchi ( @entity0 2.4%, @entity0 4.2%) and the Pashtun ( @entity0 2.7%, @entity0 1.2%). The ethnic differences persisted after adjusting for the above-mentioned sociodemographic, dietary, and clinical risk factors [adjusted odds ratio (OR) (95% CI)] were 6.42 (3.97 to 10.38) for the Sindhis, 3.58 (2.22 to 5.79) for the Muhajirs, 2.03 (1.25 to 3.29) for the Punjabis, and 1.75 (0.79 to 3.88) for the Baluchis compared to the Pashtuns). CONCLUSION: We conclude that unmeasured environmental or genetic factors account for ethnic variations in @entity3 , and deserve further study.

title: Ethnic differences and determinants of XXXX among South Asian subgroups in Pakistan.

answer: @entity3


abstract: PURPOSE: Pathologic tooth migration (PTM) is a tooth displacement which is derived from imbalance of tooth retention force and is dominantly found out in maxillary anterior area. PTM in maxillary anterior area was tried to corrected with periodontal treatment and a clear aligner in this study and the result was evaluated clinically and radiographically. METHODS: For the treatment of a @entity0 with @entity4 accompanied by @entity3 , clear aligner was applied to move teeth after a series of case-related periodontal therapy. Clinically, probing depth, @entity2 , clinical attachment level and mobility were measured pre- and post-treatment, and radiographic examination was performed as well. RESULTS: Clinically, we found the decrease of the probing depth, @entity2 , clinical attachment level and mobility. And we could also acknowledge the reduction of vertical and horizontal dimension on @entity1 radiographically. However, it is still controversial if there was an actual bone filling. CONCLUSIONS: Clear aligner is an effective appliance to move teeth since it costs little in terms of expense and time. In addition, it wraps whole crowns, providing advantages to deal with crowding, spacing, and size of arch. In short, clear aligner could be a useful treatment option for PTM @entity0 , since it provides decreased probing depth, @entity2 , clinical attachment level, mobility and esthetical restoration.

title: Orthodontic treatment for XXXX by periodontitis using clear aligner.

answer: @entity3


abstract: The AZURE trial is an ongoing phase III, academic, multi-centre, randomised trial designed to evaluate the role of @entity3 ( @entity4 ) in the adjuvant therapy of @entity1 with @entity0 . Here, we report the safety and tolerability profile of @entity4 in this setting. Eligible @entity1 received (neo)adjuvant chemotherapy and/or endocrine therapy and were randomised to receive neither additional treatment nor intravenous @entity4 4 mg. @entity4 was administered after each chemotherapy cycle to exploit potential sequence-dependent synergy. @entity4 was continued for 60 months post-randomisation (six doses in the first 6 months, eight doses in the following 24 months and five doses in the final 30 months). Serious (SAE) and non-serious adverse event (AE) data generated during the first 36 months on study were analysed for the safety population. 3,360 @entity1 were recruited to the AZURE trial. The safety population comprised 3,340 @entity1 ( @entity4 1,665; control 1,675). The addition of @entity4 to standard treatment did not significantly impact on chemotherapy delivery. SAE were similar in both treatment arms. No significant safety differences were seen apart from the occurrence of @entity2 of the jaw (ONJ) in the @entity4 group (11 confirmed cases; 0.7%; 95% confidence interval 0.3-1.1%). @entity4 in the adjuvant setting is well tolerated, and can be safely administered in addition to adjuvant therapy including chemotherapy. The adverse events were consistent with the known safety profile of @entity4 , with a low incidence of ONJ.

title: Safety of XXXX and incidence of @entity2 of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for @entity1 with @entity0 .

answer: @entity3


abstract: The AZURE trial is an ongoing phase III, academic, multi-centre, randomised trial designed to evaluate the role of @entity3 ( @entity4 ) in the adjuvant therapy of @entity1 with @entity0 . Here, we report the safety and tolerability profile of @entity4 in this setting. Eligible @entity1 received (neo)adjuvant chemotherapy and/or endocrine therapy and were randomised to receive neither additional treatment nor intravenous @entity4 4 mg. @entity4 was administered after each chemotherapy cycle to exploit potential sequence-dependent synergy. @entity4 was continued for 60 months post-randomisation (six doses in the first 6 months, eight doses in the following 24 months and five doses in the final 30 months). Serious (SAE) and non-serious adverse event (AE) data generated during the first 36 months on study were analysed for the safety population. 3,360 @entity1 were recruited to the AZURE trial. The safety population comprised 3,340 @entity1 ( @entity4 1,665; control 1,675). The addition of @entity4 to standard treatment did not significantly impact on chemotherapy delivery. SAE were similar in both treatment arms. No significant safety differences were seen apart from the occurrence of @entity2 of the jaw (ONJ) in the @entity4 group (11 confirmed cases; 0.7%; 95% confidence interval 0.3-1.1%). @entity4 in the adjuvant setting is well tolerated, and can be safely administered in addition to adjuvant therapy including chemotherapy. The adverse events were consistent with the known safety profile of @entity4 , with a low incidence of ONJ.

title: Safety of @entity3 and incidence of @entity2 of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for @entity1 with XXXX .

answer: @entity0


abstract: The AZURE trial is an ongoing phase III, academic, multi-centre, randomised trial designed to evaluate the role of @entity3 ( @entity4 ) in the adjuvant therapy of @entity1 with @entity0 . Here, we report the safety and tolerability profile of @entity4 in this setting. Eligible @entity1 received (neo)adjuvant chemotherapy and/or endocrine therapy and were randomised to receive neither additional treatment nor intravenous @entity4 4 mg. @entity4 was administered after each chemotherapy cycle to exploit potential sequence-dependent synergy. @entity4 was continued for 60 months post-randomisation (six doses in the first 6 months, eight doses in the following 24 months and five doses in the final 30 months). Serious (SAE) and non-serious adverse event (AE) data generated during the first 36 months on study were analysed for the safety population. 3,360 @entity1 were recruited to the AZURE trial. The safety population comprised 3,340 @entity1 ( @entity4 1,665; control 1,675). The addition of @entity4 to standard treatment did not significantly impact on chemotherapy delivery. SAE were similar in both treatment arms. No significant safety differences were seen apart from the occurrence of @entity2 of the jaw (ONJ) in the @entity4 group (11 confirmed cases; 0.7%; 95% confidence interval 0.3-1.1%). @entity4 in the adjuvant setting is well tolerated, and can be safely administered in addition to adjuvant therapy including chemotherapy. The adverse events were consistent with the known safety profile of @entity4 , with a low incidence of ONJ.

title: Safety of @entity3 and incidence of XXXX of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for @entity1 with @entity0 .

answer: @entity2


abstract: The AZURE trial is an ongoing phase III, academic, multi-centre, randomised trial designed to evaluate the role of @entity3 ( @entity4 ) in the adjuvant therapy of @entity1 with @entity0 . Here, we report the safety and tolerability profile of @entity4 in this setting. Eligible @entity1 received (neo)adjuvant chemotherapy and/or endocrine therapy and were randomised to receive neither additional treatment nor intravenous @entity4 4 mg. @entity4 was administered after each chemotherapy cycle to exploit potential sequence-dependent synergy. @entity4 was continued for 60 months post-randomisation (six doses in the first 6 months, eight doses in the following 24 months and five doses in the final 30 months). Serious (SAE) and non-serious adverse event (AE) data generated during the first 36 months on study were analysed for the safety population. 3,360 @entity1 were recruited to the AZURE trial. The safety population comprised 3,340 @entity1 ( @entity4 1,665; control 1,675). The addition of @entity4 to standard treatment did not significantly impact on chemotherapy delivery. SAE were similar in both treatment arms. No significant safety differences were seen apart from the occurrence of @entity2 of the jaw (ONJ) in the @entity4 group (11 confirmed cases; 0.7%; 95% confidence interval 0.3-1.1%). @entity4 in the adjuvant setting is well tolerated, and can be safely administered in addition to adjuvant therapy including chemotherapy. The adverse events were consistent with the known safety profile of @entity4 , with a low incidence of ONJ.

title: Safety of @entity3 and incidence of @entity2 of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for XXXX with @entity0 .

answer: @entity1


abstract: INTRODUCTION: The reduction of bone mineral density (BMD) levels is an important complication after renal transplantation. The prevalence of nontraumatic lesions may reach 22%. @entity0 with lower osseous mass suffer the highest number of lesions. OBJECTIVE: Evaluate BMD in @entity0 over 30-years old who have undergone renal transplantation more than 1 year prior, who attend a medical facility complaining of @entity2 and were prescribed rest or any @entity7 . @entity0 AND METHODS: One hundred twenty-three @entity0 who received a renal transplant from a cadaveric donor from 1980 through 2000 were included in the present study to measure BMD levels in the hips and the vertebral column using a densitometer (Hologic 4500 QDR). Our study complied with WHO recommendations, which define normal values as a T score >-1 SD @entity8 as a (T score between <-1 and >-2.5 SD), and @entity3 as a T score <-2.5 SD. @entity0 were divided into three groups according to gender and hormonal status. The following clinical and analytic data were collected: age, gender, race, age at onset of menopause, @entity1 ( @entity1 ), weight, size, retransplantation, period of evolution after transplantation, and @entity9 ( @entity5 ), @entity6 , and renal clearance values. RESULTS: There were 51 @entity0 (41.1%) included. Forty postmenopausal (32.5%) and premenopausal @entity0 (26%) were also included. In all @entity0 we observed a correlation between a reduction in BMD values and age, duration post-transplantation, and body weight (P<.05). Reduced BMD levels in premenopausal @entity0 were related with lower body weight, (P<.05) and elevated @entity5 levels (P<.024). CONCLUSIONS: We observed that @entity0 who had undergone transplantation displayed a moderately higher risk of suffering a @entity4 . Such risk increased in the case of @entity0 with more frequent fractures in the vertebral column. In 23.8% of @entity0 reporting @entity2 , there was no reduction in BMD levels. Therefore, we must look for other disorder, responsible for the @entity2 and prescribe adequate treatment.

title: XXXX and bone mineral density in renal transplantation.

answer: @entity2


abstract: BACKGROUND: @entity3 -intracellulare complex (MAC) is a ubiquitous pathogen found in soil and water. Environmental exposure is the primary route for MAC infection. However, specific environmental risk factors have been poorly determined in immunocompetent @entity0 with @entity2 . METHODS: A case-control study was performed with 106 @entity0 with @entity2 ( @entity0 [ @entity0 ], 23 [83]; age, 64.3    9.2 years) and 53 age-matched control @entity0 with @entity4 but not @entity5 ( @entity0 [ @entity0 ], 7[46]; age, 63.0    11.0 years). All @entity0 completed a standardized questionnaire that included questions about medical history, smoking history, @entity1 usage, age at menopause, and environment exposures. Environment exposures included soil exposure from farming or gardening; water exposure from bathing, showering, hot tub use, dishwashing, swimming, and drinking water; and pet exposure. RESULTS: No differences were identified in the @entity0 characteristics and underlying diseases. More case @entity0 experienced high soil exposure (>=  2 per week) than control @entity0 (23.6% vs 9.4%, P = .032); this remained significant after multivariate analysis (OR, 5.9; 95% CI, 1.4-24.7; P = .015). There were no significant differences in other environmental exposures. Case @entity0 with high soil exposure were significantly older than those with low soil exposure (67.3    7.3 years vs 64.3    9.5 years, P = .037). Other characteristics, underlying diseases, and mycobacterial species did not differ between the two groups. CONCLUSIONS: @entity0 with @entity2 had significantly more soil exposure than noninfected control @entity0 , which suggests that environmental soil exposure is a likely risk factor for the development of @entity2 .

title: Environmental risk factors for pulmonary XXXX -intracellulare complex disease.

answer: @entity3


abstract: AIMS: The present study was initiated by a very recent histochemical observation of lipid accumulation in the renal cortex of a @entity0 who died in a @entity6 . Two older reports of lipid accumulation in the kidneys of @entity0 who died, most likely in a state of non-regulated @entity1 , supported this observation. We have examined whether lipid accumulation in the renal cortex is characteristic of @entity6 and, if so, which type of lipid accumulates. METHODS: Three groups were studied. Ten subjects who died in a @entity6 , eight @entity1 who died of known causes unrelated to @entity1 , and seven normal control subjects without any diagnosed @entity1 who died of known causes. All were subjected to histological examination for lipid accumulation in the renal cortex. Detailed analysis of cortex lipids was performed for two of the subjects who died in a @entity6 and all @entity1 controls as well as non- @entity1 control subjects. RESULTS: All subjects who died in a @entity6 showed @entity5 staining strongly for lipid in the proximal tubules. Neither normal controls nor non-coma @entity1 showed these lesions. Compared with normal controls, renal cortex lipid was about tripled in the two analysed @entity6 subjects due to 60-100-fold increases of @entity3 . The non-coma @entity1 did not differ from the other controls with respect to @entity3 or other types of lipid, except that @entity4 were elevated, though still a quantitatively minor component. CONCLUSION: Our findings strongly indicate that @entity5 in the proximal tubules are characteristic of @entity6 and that they are caused by accumulated @entity3 . Therefore, histological examination of renal cortex using a lipid stain may be a useful forensic tool in establishing @entity6 as the cause of @entity2 .

title: Accumulation of XXXX in the proximal tubule of the kidney in @entity6 .

answer: @entity3


abstract: AIMS: The present study was initiated by a very recent histochemical observation of lipid accumulation in the renal cortex of a @entity0 who died in a @entity6 . Two older reports of lipid accumulation in the kidneys of @entity0 who died, most likely in a state of non-regulated @entity1 , supported this observation. We have examined whether lipid accumulation in the renal cortex is characteristic of @entity6 and, if so, which type of lipid accumulates. METHODS: Three groups were studied. Ten subjects who died in a @entity6 , eight @entity1 who died of known causes unrelated to @entity1 , and seven normal control subjects without any diagnosed @entity1 who died of known causes. All were subjected to histological examination for lipid accumulation in the renal cortex. Detailed analysis of cortex lipids was performed for two of the subjects who died in a @entity6 and all @entity1 controls as well as non- @entity1 control subjects. RESULTS: All subjects who died in a @entity6 showed @entity5 staining strongly for lipid in the proximal tubules. Neither normal controls nor non-coma @entity1 showed these lesions. Compared with normal controls, renal cortex lipid was about tripled in the two analysed @entity6 subjects due to 60-100-fold increases of @entity3 . The non-coma @entity1 did not differ from the other controls with respect to @entity3 or other types of lipid, except that @entity4 were elevated, though still a quantitatively minor component. CONCLUSION: Our findings strongly indicate that @entity5 in the proximal tubules are characteristic of @entity6 and that they are caused by accumulated @entity3 . Therefore, histological examination of renal cortex using a lipid stain may be a useful forensic tool in establishing @entity6 as the cause of @entity2 .

title: Accumulation of @entity3 in the proximal tubule of the kidney in XXXX .

answer: @entity6


abstract: BACKGROUND AND PURPOSE: The genetic influence on carotid @entity4 plaque is mostly unknown. This study examines the association between carotid plaque and single @entity3 polymorphisms in selected genes implicated in @entity1 and endothelial function. METHODS: A total of 43 genes (197 single @entity3 polymorphisms) involved in @entity1 and endothelial function were interrogated in 287 Dominicans from the Northern Manhattan Study (mean age, 64  7 years; 58% @entity0 ) who had undergone high-resolution B-mode ultrasound for examination of carotid plaque. Using an additive genetic model, multiple logistic regression analyses were conducted, a within-gene haplotype analysis was performed, and interactions between genes were examined. Results were validated in an independent set of 301 Dominicans. RESULTS: Carotid plaque was present in 143 (47%) @entity0 . Nine genes had at least 1 single @entity3 polymorphism associated (P <=0.01) with carotid plaque phenotypes: @entity2 , @entity7 , @entity11 , @entity13 , @entity9 , @entity5 , @entity6 , @entity12 , and @entity10 . Single @entity3 polymorphisms in @entity13 , @entity9 , @entity6 , @entity12 , and @entity10 were also implicated with the same carotid phenotype in the validation analysis. Haplotype analysis revealed an additional gene of interest, @entity8 . CONCLUSIONS: We report novel associations between variations in 10 genes involved in @entity1 and endothelial function and carotid plaque phenotypes in a Dominican sample, with replication for 5 genes in an independent Dominican sample.

title: Carotid plaque and candidate genes related to XXXX and endothelial function in Hispanics from northern Manhattan.

answer: @entity1


abstract: The use of nesiritide in the improvement of @entity0 hemodynamics, decreased length of stay (LOS), and rehospitalization is discussed. Nesiritide is a useful agent for the treatment of the acutely decompensated @entity1 @entity0 . Previous trials suggest that the use of nesiritide results in improved outcomes as compared with other agents. To date, there are no data comparing nesiritide to @entity2 in the treatment of the acutely decompensated @entity1 @entity0 . Fifty-five @entity0 admitted to the @entity1 service were identified retrospectively; 29 received nesiritide and 26 received @entity2 . Baseline characteristics, hemodynamic data, and LOS data were collected. Primary outcomes were the overall LOS, intensive care LOS, and readmission within 30 days of discharge. Other outcomes included duration of vasoactive agents used, overall diuresis, and total cost of therapy. Baseline hemodynamic data were similar between groups. @entity0 in the @entity2 group had an overall LOS of 8.2 days compared to 7 days in the nesiritide group (p = NS). LOS in the intensive care unit was 5.9 days in the @entity2 group compared with 3.9 days in the nesiritide group (p = 0.007). Readmission at 30 days was 28% in the @entity2 group compared with 16% in the nesiritide group (p = NS). Infusion time was shorter in the nesiritide group, 50 versus 117 hours (p = 0.001). Cost of therapy (cost of bed, supplies, and drug) was  398 less per @entity0 receiving nesiritide. The use of nesiritide led to improvement in @entity0 hemodynamics and resulted in a trend toward decreases in LOS and rehospitalization. Total cost of therapy was lower in the nesiritide group as compared to those @entity0 treated with @entity2 .

title: Effect of nesiritide versus @entity2 in the treatment of acute decompensated XXXX .

answer: @entity1


abstract: The use of nesiritide in the improvement of @entity0 hemodynamics, decreased length of stay (LOS), and rehospitalization is discussed. Nesiritide is a useful agent for the treatment of the acutely decompensated @entity1 @entity0 . Previous trials suggest that the use of nesiritide results in improved outcomes as compared with other agents. To date, there are no data comparing nesiritide to @entity2 in the treatment of the acutely decompensated @entity1 @entity0 . Fifty-five @entity0 admitted to the @entity1 service were identified retrospectively; 29 received nesiritide and 26 received @entity2 . Baseline characteristics, hemodynamic data, and LOS data were collected. Primary outcomes were the overall LOS, intensive care LOS, and readmission within 30 days of discharge. Other outcomes included duration of vasoactive agents used, overall diuresis, and total cost of therapy. Baseline hemodynamic data were similar between groups. @entity0 in the @entity2 group had an overall LOS of 8.2 days compared to 7 days in the nesiritide group (p = NS). LOS in the intensive care unit was 5.9 days in the @entity2 group compared with 3.9 days in the nesiritide group (p = 0.007). Readmission at 30 days was 28% in the @entity2 group compared with 16% in the nesiritide group (p = NS). Infusion time was shorter in the nesiritide group, 50 versus 117 hours (p = 0.001). Cost of therapy (cost of bed, supplies, and drug) was  398 less per @entity0 receiving nesiritide. The use of nesiritide led to improvement in @entity0 hemodynamics and resulted in a trend toward decreases in LOS and rehospitalization. Total cost of therapy was lower in the nesiritide group as compared to those @entity0 treated with @entity2 .

title: Effect of nesiritide versus XXXX in the treatment of acute decompensated @entity1 .

answer: @entity2


abstract: To date, no study shows a @entity1 with the use of irrigation during appendectomy. @entity1 rate for laparoscopic and open appendectomy is 3.3 and 2.6 per cent. The purpose of this study is to determine if irrigation at appendectomy decreases the @entity3 rate. Retrospective chart review of 176 consecutive appendectomies, open (39%) and laparoscopic (61%), at a university affiliated tertiary care facility from July 2007 to November 2008 for use of intraoperative irrigation was performed. @entity0 under age 18 were excluded. There were no differences between the irrigation groups in regards to age, sex, or weight. Perforation was observed in 28 per cent (50/176), of which 86 per cent (43/50) of @entity0 received intraoperative irrigation. Eleven @entity0 (9.6%) with irrigation developed @entity1 compared with two (3.3%) @entity0 without irrigation (P = 0.22). Our results do not show decrease in @entity3 with use of intraoperative irrigation. Thirteen @entity0 developed @entity1 : 11 with irrigation, two without irrigation. Ten of 13 @entity0 who developed @entity2 were perforated; nine with irrigation and one without. These results suggest routine use of intraoperative irrigation for appendectomies does not prevent @entity3 formation, adds extra costs, and may be avoided.

title: Does use of intraoperative irrigation with open or laparoscopic appendectomy reduce post-operative XXXX ?

answer: @entity3


abstract: BACKGROUND: @entity12 is the most severe phenotype of the peroxisome biogenesis disorders caused by mutations in PEX genes. @entity15 genes are most frequently implicated. Clinical phenotype can't predict the mutated gene. AIM: To report a novel mutation in the @entity16 gene in @entity0 with typical @entity12 . CASE REPORT: the @entity0 was the second @entity0 to consanguineous parents; the 1st @entity0 was dead with @entity11 . At two month of age, we noted a severe @entity11 and @entity8 , characteristic facial @entity2 and @entity4 . Sensorial investigations showed @entity10 . Cerebral tomography revealed @entity1 . Radiological examination revealed @entity7 stippling of the patellas. The clinical diagnosis was supported by measurement of plasma very-long-chain @entity9 , with elevated C24:0/C22:0, C26:0/C22:0 ratios and decreased @entity14 peak. The diagnosis was confirmed by dosage of @entity13 activity in fibroblasts which was very low. Ultrastructural examinations showed the presence of peroxisomal ghosts. Genetic analysis demonstrated a new mutation in @entity16 gene.The @entity3 occurred at the age of 8 months of refractor @entity5 and @entity6 . CONCLUSION: The poor prognosis of @entity12 incites paediatricians to consider this disorder in etiological investigations of precocious @entity11 . Biochemical diagnosis, available in Tunisia, offers opportunity of prenatal diagnosis in affected families.

title: [A novel mutation in @entity16 gene in XXXX : a case report].

answer: @entity12


abstract: BACKGROUND: @entity12 is the most severe phenotype of the peroxisome biogenesis disorders caused by mutations in PEX genes. @entity15 genes are most frequently implicated. Clinical phenotype can't predict the mutated gene. AIM: To report a novel mutation in the @entity16 gene in @entity0 with typical @entity12 . CASE REPORT: the @entity0 was the second @entity0 to consanguineous parents; the 1st @entity0 was dead with @entity11 . At two month of age, we noted a severe @entity11 and @entity8 , characteristic facial @entity2 and @entity4 . Sensorial investigations showed @entity10 . Cerebral tomography revealed @entity1 . Radiological examination revealed @entity7 stippling of the patellas. The clinical diagnosis was supported by measurement of plasma very-long-chain @entity9 , with elevated C24:0/C22:0, C26:0/C22:0 ratios and decreased @entity14 peak. The diagnosis was confirmed by dosage of @entity13 activity in fibroblasts which was very low. Ultrastructural examinations showed the presence of peroxisomal ghosts. Genetic analysis demonstrated a new mutation in @entity16 gene.The @entity3 occurred at the age of 8 months of refractor @entity5 and @entity6 . CONCLUSION: The poor prognosis of @entity12 incites paediatricians to consider this disorder in etiological investigations of precocious @entity11 . Biochemical diagnosis, available in Tunisia, offers opportunity of prenatal diagnosis in affected families.

title: [A novel mutation in XXXX gene in @entity12 : a case report].

answer: @entity16


abstract: A 57-year-old @entity0 was admitted to our hospital with an abnormal shadow on chest X-ray film. Computed tomography (CT) scanning demonstrated a low-density, destructive mass on the right 8th rib. The maximum standardized uptake value of the @entity1 measured by positron emission tomography (PET) was 2.9, indicating @entity1 . Wide resection of the @entity1 , including the right 8th rib and the 7th to 8th intercostal muscle, was performed. Chest wall reconstruction was achieved with Composix Mesh. The histologic findings revealed proliferation of histiocytes and eosinophil infiltration. No malignant cells were detected in the @entity1 . Histiocytes stained for @entity3 protein and @entity4 , compatible with a diagnosis of @entity2 ( @entity2 ). @entity2 in the ribs is very rare and difficult to diagnose using CT or PET. Tumor biopsy or resection is needed to diagnose @entity2 .

title: [ XXXX of the rib in adult male].

answer: @entity2


abstract: BACKGROUND: Ischemic postconditioning (IPost) has aroused much attention since 2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has rarely been reported. The present study was undertaken to investigate whether miRNAs were involved in the protective effect of IPost against @entity3 -reperfusion (IR) injury and the probable mechanisms involved. METHODS: Thirty SD @entity0 weighing 250-300 g were equally randomized to three groups: Control group, where the @entity0 were treated with thoracotomy only; IR group, where the @entity0 were treated with @entity1 for 60 min and reperfusion for 180 min; and IPost group, where the @entity0 were treated with 3 cycles of transient IR just before reperfusion. The extent of @entity2 , LDH and CK activities were measured immediately after treatment. Myocardial apoptosis was detected by TUNEL assay. The myocardial tissue was collected after IR or IPost stimulation to evaluate the miRNAs expression level by miRNA-microarray and quantitative real-time RT-PCR. Real-time PCR was conducted to identify changes in mRNA expression of apoptosis-related genes such as @entity5 , @entity6 and @entity7 ( @entity7 ), and Western blot was used to compare the protein expression level of @entity7 in the three groups. The miRNA mimics and anti-miRNA oligonucleotides (AMO) were transferred into the cultured neonatal cardiomyocytes and myocardium before they were treated with IR. The effect of miRNAs on apoptosis was determined by flow cytometry and TUNEL assay. @entity7 , as one of the candidate target of @entity9 , was compared during IR after the @entity9 mimic or AMO-133a was transferred into the myocardium. RESULTS: IPost reduced the IR-induced @entity4 size of the left ventricle, and decreased CK and LDH levels. TUNEL assay showed that myocardial apoptosis was attenuated by IPost compared with IR. MiRNA-microarray and RT-PCR showed that myocardial-specific @entity8 and @entity9 were down-regulated by IR, and up-regulated by IPost compared with IR. Furthermore, IPost up-regulated the mRNA expression of @entity5 , down-regulated that of @entity6 and @entity7 . Western blot showed that IPost also down-regulated the @entity7 protein expression compared with IR. The results of flow cytometry and TUNEL assay showed that up-regulation of @entity8 and @entity9 decreased apoptosis of cardiomyocytes. @entity9 mimic down-regulated @entity7 protein expression and attenuated IR-induced apoptosis. CONCLUSION: MiRNAs are associated with the protective effect of IPost against @entity3 . IPost can up-regulate @entity8 and @entity9 , and decrease apoptosis of cardiomyocyte. Myocardial-specific @entity8 and @entity9 may play an important role in IPost protection by regulating apoptosis-related genes. @entity9 may attenuate apoptosis of myocardiocytes by targeting @entity7 .

title: Role of XXXX and @entity9 in @entity3 postconditioning.

answer: @entity8


abstract: BACKGROUND: Ischemic postconditioning (IPost) has aroused much attention since 2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has rarely been reported. The present study was undertaken to investigate whether miRNAs were involved in the protective effect of IPost against @entity3 -reperfusion (IR) injury and the probable mechanisms involved. METHODS: Thirty SD @entity0 weighing 250-300 g were equally randomized to three groups: Control group, where the @entity0 were treated with thoracotomy only; IR group, where the @entity0 were treated with @entity1 for 60 min and reperfusion for 180 min; and IPost group, where the @entity0 were treated with 3 cycles of transient IR just before reperfusion. The extent of @entity2 , LDH and CK activities were measured immediately after treatment. Myocardial apoptosis was detected by TUNEL assay. The myocardial tissue was collected after IR or IPost stimulation to evaluate the miRNAs expression level by miRNA-microarray and quantitative real-time RT-PCR. Real-time PCR was conducted to identify changes in mRNA expression of apoptosis-related genes such as @entity5 , @entity6 and @entity7 ( @entity7 ), and Western blot was used to compare the protein expression level of @entity7 in the three groups. The miRNA mimics and anti-miRNA oligonucleotides (AMO) were transferred into the cultured neonatal cardiomyocytes and myocardium before they were treated with IR. The effect of miRNAs on apoptosis was determined by flow cytometry and TUNEL assay. @entity7 , as one of the candidate target of @entity9 , was compared during IR after the @entity9 mimic or AMO-133a was transferred into the myocardium. RESULTS: IPost reduced the IR-induced @entity4 size of the left ventricle, and decreased CK and LDH levels. TUNEL assay showed that myocardial apoptosis was attenuated by IPost compared with IR. MiRNA-microarray and RT-PCR showed that myocardial-specific @entity8 and @entity9 were down-regulated by IR, and up-regulated by IPost compared with IR. Furthermore, IPost up-regulated the mRNA expression of @entity5 , down-regulated that of @entity6 and @entity7 . Western blot showed that IPost also down-regulated the @entity7 protein expression compared with IR. The results of flow cytometry and TUNEL assay showed that up-regulation of @entity8 and @entity9 decreased apoptosis of cardiomyocytes. @entity9 mimic down-regulated @entity7 protein expression and attenuated IR-induced apoptosis. CONCLUSION: MiRNAs are associated with the protective effect of IPost against @entity3 . IPost can up-regulate @entity8 and @entity9 , and decrease apoptosis of cardiomyocyte. Myocardial-specific @entity8 and @entity9 may play an important role in IPost protection by regulating apoptosis-related genes. @entity9 may attenuate apoptosis of myocardiocytes by targeting @entity7 .

title: Role of @entity8 and @entity9 in XXXX postconditioning.

answer: @entity3


abstract: BACKGROUND: Ischemic postconditioning (IPost) has aroused much attention since 2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has rarely been reported. The present study was undertaken to investigate whether miRNAs were involved in the protective effect of IPost against @entity3 -reperfusion (IR) injury and the probable mechanisms involved. METHODS: Thirty SD @entity0 weighing 250-300 g were equally randomized to three groups: Control group, where the @entity0 were treated with thoracotomy only; IR group, where the @entity0 were treated with @entity1 for 60 min and reperfusion for 180 min; and IPost group, where the @entity0 were treated with 3 cycles of transient IR just before reperfusion. The extent of @entity2 , LDH and CK activities were measured immediately after treatment. Myocardial apoptosis was detected by TUNEL assay. The myocardial tissue was collected after IR or IPost stimulation to evaluate the miRNAs expression level by miRNA-microarray and quantitative real-time RT-PCR. Real-time PCR was conducted to identify changes in mRNA expression of apoptosis-related genes such as @entity5 , @entity6 and @entity7 ( @entity7 ), and Western blot was used to compare the protein expression level of @entity7 in the three groups. The miRNA mimics and anti-miRNA oligonucleotides (AMO) were transferred into the cultured neonatal cardiomyocytes and myocardium before they were treated with IR. The effect of miRNAs on apoptosis was determined by flow cytometry and TUNEL assay. @entity7 , as one of the candidate target of @entity9 , was compared during IR after the @entity9 mimic or AMO-133a was transferred into the myocardium. RESULTS: IPost reduced the IR-induced @entity4 size of the left ventricle, and decreased CK and LDH levels. TUNEL assay showed that myocardial apoptosis was attenuated by IPost compared with IR. MiRNA-microarray and RT-PCR showed that myocardial-specific @entity8 and @entity9 were down-regulated by IR, and up-regulated by IPost compared with IR. Furthermore, IPost up-regulated the mRNA expression of @entity5 , down-regulated that of @entity6 and @entity7 . Western blot showed that IPost also down-regulated the @entity7 protein expression compared with IR. The results of flow cytometry and TUNEL assay showed that up-regulation of @entity8 and @entity9 decreased apoptosis of cardiomyocytes. @entity9 mimic down-regulated @entity7 protein expression and attenuated IR-induced apoptosis. CONCLUSION: MiRNAs are associated with the protective effect of IPost against @entity3 . IPost can up-regulate @entity8 and @entity9 , and decrease apoptosis of cardiomyocyte. Myocardial-specific @entity8 and @entity9 may play an important role in IPost protection by regulating apoptosis-related genes. @entity9 may attenuate apoptosis of myocardiocytes by targeting @entity7 .

title: Role of @entity8 and XXXX in @entity3 postconditioning.

answer: @entity9


abstract: CONTEXT: Because diagnosis is typically thought of as purely a @entity0 attribute, it is considered a critical factor in risk-adjustment policies designed to reward efficient and high-quality care. OBJECTIVE: To determine the association between frequency of diagnoses for chronic conditions in geographic areas and case-fatality rate among Medicare beneficiaries. DESIGN, SETTING, AND @entity0 : Cross-sectional analysis of the mean number of 9 serious chronic conditions ( @entity1 , @entity10 , @entity7 , @entity9 , @entity11 , severe @entity6 , @entity2 with @entity8 , @entity3 , and @entity5 ) diagnosed in 306 hospital referral regions (HRRs) in the United States; HRRs were divided into quintiles of diagnosis frequency. @entity0 were 5,153,877 fee-for-service Medicare beneficiaries in 2007. MAIN OUTCOME MEASURES: Age/sex/race-adjusted case-fatality rates. RESULTS: Diagnosis frequency ranged across HRRs from 0.58 chronic conditions in Grand Junction, Colorado, to 1.23 in Miami, Florida (mean, 0.90 [95% confidence interval {CI}, 0.89-0.91]; median, 0.87 [interquartile range, 0.80-0.96]). The number of conditions diagnosed was related to risk of @entity4 : among @entity0 diagnosed with 0, 1, 2, and 3 conditions the case-fatality rate was 16, 45, 93, and 154 per 1000, respectively. As regional diagnosis frequency increased, however, the case fatality associated with a chronic condition became progressively less. Among @entity0 diagnosed with 1 condition, the case-fatality rate decreased in a stepwise fashion across quintiles of diagnosis frequency, from 51 per 1000 in the lowest quintile to 38 per 1000 in the highest quintile (relative rate, 0.74 [95% CI, 0.72-0.76]). For @entity0 diagnosed with 3 conditions, the corresponding case-fatality rates were 168 and 137 per 1000 (relative rate, 0.81 [95% CI, 0.79-0.84]). CONCLUSION: Among fee-for-service Medicare beneficiaries, there is an inverse relationship between the regional frequency of diagnoses and the case-fatality rate for chronic conditions.

title: Geographic variation in diagnosis frequency and risk of XXXX among Medicare beneficiaries.

answer: @entity4


abstract: BACKGROUND: There continues to be controversy surrounding the appropriate use of radiofrequency ablation (RFA) for the treatment of @entity2 ( @entity2 ). This study analyzes outcomes data of @entity2 @entity0 who underwent laparoscopic RFA. Outcomes of @entity0 determined to be technically resectable were compared to @entity0 with unresectable disease. METHODS: Data from all @entity0 with @entity2 who underwent laparoscopic RFA between 1996 and 2006 were retrospectively reviewed. A blinded independent hepatobiliary-trained surgical oncologist reviewed preoperative diagnostic imaging studies to determine resectability. Outcomes data for @entity0 with disease deemed anatomically resectable and unresectable were analyzed and compared. Survival was calculated by the Kaplan-Meier method. The log rank test was performed to assess significance in survival. RESULTS: A total of 113 @entity0 who underwent laparoscopic RFA for @entity2 were identified. Twelve @entity0 who underwent concurrent hepatic resection were excluded. Of the remaining @entity0 , 64 were determined to have disease that was be technically resectable and 37 unresectable as a result of @entity1 number and/or distribution. Median and 5-year survival of the potentially resectable group was 4.3years and 48.7%, compared to 2.2 years and 18.4% in the unresectable group (P = 0.002). Median disease-free survival in the resectable group was 15.0 months, compared to 16.4 months in the unresectable group (P = 0.796). No postoperative mortality was reported in the technically resectable group, and the rate of major complications was 3.1%. CONCLUSIONS: Laparoscopic RFA of resectable @entity2 can produce comparable long-term survival to hepatic resection in carefully selected @entity0 , with favorable morbidity and mortality.

title: Outcome after laparoscopic radiofrequency ablation of technically resectable XXXX .

answer: @entity2


abstract: The present study was planned to investigate differences in psychopathological features, eating behaviour and eating habits between @entity1 @entity0 with and without @entity7 . It also aimed to identify specific relationships between affective symptoms and eating behaviour in @entity1 @entity0 with @entity7 . Eighty-four @entity1 @entity0 were studied (40 with @entity7 , 44 non- @entity7 ). Psychiatric comorbidities were assessed with the @entity6 ( @entity6 ). @entity3 were measured with the Beck Depression Inventory (BDI) and @entity2 with the state-trait @entity2 inventory (STAI). Eating habits (emotional and restrained eating) were assessed by the Dutch eating behaviour questionnaire (DEBQ). Food diaries were used for assessing naturalistic eating behaviour (food intake) and mood before and after food intake. @entity7 subjects exhibited higher levels of comorbidity (in particular @entity5 , @entity2 and @entity4 ), higher @entity3 , trait @entity2 , external and emotional eating scores than non- @entity7 subjects. Regression analyses revealed that @entity2 were significant predictors for @entity7 status. In the @entity7 group, @entity3 were significantly related to emotional eating and food intake and negatively related to restraint. @entity2 was significantly related to emotional eating. In general, food intake significantly enhanced mood. Mood was worse on the days with self-reported binge eating episodes than on nonbinge days. These results are discussed with regard to aetiological models for @entity7 and for @entity7 being a distinct diagnostic category separate from @entity1 .

title: Associations of negative affect and eating behaviour in XXXX @entity0 with and without binge eating disorder.

answer: @entity1


abstract: The present study was planned to investigate differences in psychopathological features, eating behaviour and eating habits between @entity1 @entity0 with and without @entity7 . It also aimed to identify specific relationships between affective symptoms and eating behaviour in @entity1 @entity0 with @entity7 . Eighty-four @entity1 @entity0 were studied (40 with @entity7 , 44 non- @entity7 ). Psychiatric comorbidities were assessed with the @entity6 ( @entity6 ). @entity3 were measured with the Beck Depression Inventory (BDI) and @entity2 with the state-trait @entity2 inventory (STAI). Eating habits (emotional and restrained eating) were assessed by the Dutch eating behaviour questionnaire (DEBQ). Food diaries were used for assessing naturalistic eating behaviour (food intake) and mood before and after food intake. @entity7 subjects exhibited higher levels of comorbidity (in particular @entity5 , @entity2 and @entity4 ), higher @entity3 , trait @entity2 , external and emotional eating scores than non- @entity7 subjects. Regression analyses revealed that @entity2 were significant predictors for @entity7 status. In the @entity7 group, @entity3 were significantly related to emotional eating and food intake and negatively related to restraint. @entity2 was significantly related to emotional eating. In general, food intake significantly enhanced mood. Mood was worse on the days with self-reported binge eating episodes than on nonbinge days. These results are discussed with regard to aetiological models for @entity7 and for @entity7 being a distinct diagnostic category separate from @entity1 .

title: Associations of negative affect and eating behaviour in @entity1 XXXX with and without binge eating disorder.

answer: @entity0


abstract: BACKGROUND: Echocardiographic parameters could be implicated in the development of apical asynergy (characterized by apical sequestration or apical @entity3 ) and worse cardiovascular outcome in @entity0 with @entity4 ( @entity4 ). HYPOTHESIS: Echocardiographic parameters and morphological patterns of left ventriculograms are associated with @entity1 and mortality in @entity0 with @entity4 . METHODS: We followed 47 cases with echocardiographically documented @entity4 . Echocardiographic findings of the extent and degree of @entity5 , sustained cavity obliteration, and paradoxical diastolic jet flow were measured. All @entity0 underwent a cardiac catheterization except for the cases whose informed consent was not acquired. The clinical manifestations were assessed and recorded by the attending physicians during 35.4    23.7 months follow-up. RESULTS: Among the 47 @entity0 with @entity4 , 30 @entity0 presented as the "pure" form and 17 @entity0 present as the "mixed" form. Seventeen of 28 @entity0 with sustained cavity obliteration showed paradoxical flow by echocardiography. Thirty-one underwent left ventriculograms and showed @entity2 , including "ace-of-spades" configuration (15/31), apical sequestration (12/31), and apical @entity3 (4/31). The results demonstrated that cardiovascular morbidities occurred in 21 of 47 @entity0 and were closely related to the presence of mixed form @entity4 , cavity obliteration, and paradoxical flow by univariate and multivariate Cox analysis. During the period of follow-up, 4 @entity0 (9.5%) died, and among them 3 had concomitant apical @entity3 . CONCLUSIONS: We concluded that detection of cavity obliteration and paradoxical flow and discrimination of pure form from mixed form by echocardiography, as well apical sequestration from apical @entity3 in @entity4 @entity0 , is warranted.

title: Apical XXXX : correlations between echocardiographic parameters, angiographic left ventricular morphology, and clinical outcomes.

answer: @entity4


abstract: @entity13 and @entity14 and their derivatives have critical functions and pharmacological applications in the brain. @entity12 and nucleobases are precursors of @entity10 , which serve as the energy-rich currency of intermediary metabolism and as precursors of nucleic acids. @entity12 (e.g., @entity6 ) and @entity10 are key signaling molecules that modulate brain function through interaction with cell surface receptors. @entity3 involving @entity12 and their metabolites range from @entity5 and @entity4 conditions to @entity2 . @entity11 analogs are used clinically in the treatment of @entity7 and @entity9 . @entity12 are hydrophilic molecules, and transportability across cell membranes via specialized @entity11 transporter (NT) proteins is a critical determinant of their metabolism and, for @entity11 drugs, their pharmacologic actions. In mammals, there are two types of @entity11 transport process: bidirectional equilibrative processes driven by chemical gradients, and unidirectional concentrative processes driven by @entity8 (and proton) electrochemical gradients. In mammals, these processes, both of which are present in brain, are mediated by members of two structurally unrelated membrane protein families (ENT and CNT, respectively). In this Chapter, we review current knowledge of cellular, physiological, pathophysiological and therapeutic aspects of ENT and CNT distribution and function in the @entity0 brain, including studies with NT inhibitors and new research involving NT knockout and @entity1 . We also describe recent progress in functional and molecular studies of ENT and CNT proteins, and summarize emerging evidence of other transporter families with demonstrated or potential roles in the transport of @entity12 and their derivatives in the brain.

title: Molecular biology of XXXX transporters and their distributions and functions in the brain.

answer: @entity11


abstract: PURPOSE: Many techniques are available for closed reduction and percutaneous fixation of @entity6 . The palm tree technique was described by Kapandji in 1989. In that technique three curved wires are inserted through one hole at the V-shaped insertion of the deltoid muscle. It is a good technique but it has some disadvantages. In this study we introduced some modifications for the technique, and we evaluated the clinical results of the modified technique in treatment of 18 cases. METHODS: Eighteen @entity0 with displaced @entity6 were treated by closed reduction and percutaneous fixation with the palm tree technique after minor modifications. The age of the @entity0 ranged from 38 to 75 years with an average of 56 years. Eleven were females and seven were males. The @entity3 were two-part in 13 cases and three-part @entity3 in five cases. RESULTS: The average time of healing was seven weeks. The follow-up period ranged from 14 months to 39 months with an average of 22 months. The Constant score ranged from 45 to 88 with a mean of 73. The results were satisfactory in 77% and unsatisfactory in 23% of the cases. The complications included pin tract infection in two cases, intraarticular wire migration in one case, @entity1 around the wires in three cases and malunion with @entity2 in one case. No cases were complicated by @entity4 , loss of fixation or avascular @entity1 of the humeral head. CONCLUSIONS: The palm tree technique is a good method for fixation of @entity6 . It produces good grip in both of the proximal and distal fragments and allows for @entity5 . Our modifications allow for easy insertion of the wires, increase the stability of fixation and minimize the risk of complications.

title: Results of the percutaneous pinning of proximal humerus XXXX with a modified palm tree technique.

answer: @entity3


abstract: PURPOSE: To understand the current state of severe contact lens (CL)-associated @entity1 in Japan. METHOD: The survey was conducted by the Japan Contact Lens Society and the Japanese Association for @entity2 in 224 facilities from April 2007 to March 2009. @entity0 who were diagnosed with CL-associated @entity1 and hospitalized for treatment were enrolled. Clinical characteristics of the @entity1 , microbiologic findings and the status of CL hygiene were studied. RESULTS: A total of 350 @entity0 were investigated, with an average age of 28.0 (9-90) years. Acanthamoeba was identified in 85 (24.3%) corneal specimens and Pseudomonus aeruginosa in 70 (20.0%) cases. One hundred ninety six (56.0%) @entity0 were frequent replacement soft CL users. Extended wearing of daily-use CLs was found in 77 (22.0%) @entity0 . Only 67 cases maintained good CL hygiene by daily rubbing-washing and the poor CL care situation was reviewed. CONCLUSION: The most frequently detected pathogenic microorganism was Acanthamoeba, followed by Pseudomonus aeruginosa. Our survey showed the importance of keeping good CL hygiene by proper lens care, and improvement of CL-related social regulations is urgently needed.

title: [Survey of severe contact lens-associated XXXX in Japan].

answer: @entity1


abstract: We report a paradoxical effect of @entity4 ( @entity8 ) observed in a 3-year-old @entity0 with cryptogenic localization-related @entity2 . On admission she experienced two types of @entity3 that were confirmed by ictal EEGs : @entity3 ( @entity3 ) originating from the left hemisphere and combined @entity3 that began with repetitive @entity3 immediately followed by a @entity9 . These @entity3 did not possess asymmetrical features, but the ictal EEGs showed left-side dominant multiple spike-waves. The patent's interictal EEGs on admission showed left posterior temporal- parietal spikes during wakefulness and frequent diffuse spike-waves during sleep. In the process of introduction and increase in the dosage of @entity8 , an aggravation of @entity2 discharges, especially a dramatic increase in diffuse spike-waves during sleep, was observed. In the same period of time, @entity3 not followed by @entity9 newly appeared, and there was an increase in the frequency of @entity3 and combined @entity3 . Marked improvement of @entity2 discharges, namely the disappearance of diffuse discharges, and complete suppression of all types of @entity3 were achieved by the introduction of @entity6 ( @entity7 ) along with the withdrawal of @entity8 . During the clinical course, the @entity0 did not display any signs or symptoms of @entity8 @entity1 , @entity5 of @entity8 or metabolic aberration. The paradoxical effect of @entity7 in localization-related @entity2 is well-known, yet in this case, @entity8 displayed a similar paradoxical effect. Additionally, @entity7 was efficacious in the suppression of secondary bilateral synchrony on EEG and also successfully controlled @entity3 , combined @entity3 and @entity3 .

title: [Aggravation of @entity2 by XXXX in a @entity0 with cryptogenic localization-related @entity2 ].

answer: @entity4


abstract: We report a paradoxical effect of @entity4 ( @entity8 ) observed in a 3-year-old @entity0 with cryptogenic localization-related @entity2 . On admission she experienced two types of @entity3 that were confirmed by ictal EEGs : @entity3 ( @entity3 ) originating from the left hemisphere and combined @entity3 that began with repetitive @entity3 immediately followed by a @entity9 . These @entity3 did not possess asymmetrical features, but the ictal EEGs showed left-side dominant multiple spike-waves. The patent's interictal EEGs on admission showed left posterior temporal- parietal spikes during wakefulness and frequent diffuse spike-waves during sleep. In the process of introduction and increase in the dosage of @entity8 , an aggravation of @entity2 discharges, especially a dramatic increase in diffuse spike-waves during sleep, was observed. In the same period of time, @entity3 not followed by @entity9 newly appeared, and there was an increase in the frequency of @entity3 and combined @entity3 . Marked improvement of @entity2 discharges, namely the disappearance of diffuse discharges, and complete suppression of all types of @entity3 were achieved by the introduction of @entity6 ( @entity7 ) along with the withdrawal of @entity8 . During the clinical course, the @entity0 did not display any signs or symptoms of @entity8 @entity1 , @entity5 of @entity8 or metabolic aberration. The paradoxical effect of @entity7 in localization-related @entity2 is well-known, yet in this case, @entity8 displayed a similar paradoxical effect. Additionally, @entity7 was efficacious in the suppression of secondary bilateral synchrony on EEG and also successfully controlled @entity3 , combined @entity3 and @entity3 .

title: [Aggravation of XXXX by @entity4 in a @entity0 with cryptogenic localization-related @entity2 ].

answer: @entity2


abstract: We report a paradoxical effect of @entity4 ( @entity8 ) observed in a 3-year-old @entity0 with cryptogenic localization-related @entity2 . On admission she experienced two types of @entity3 that were confirmed by ictal EEGs : @entity3 ( @entity3 ) originating from the left hemisphere and combined @entity3 that began with repetitive @entity3 immediately followed by a @entity9 . These @entity3 did not possess asymmetrical features, but the ictal EEGs showed left-side dominant multiple spike-waves. The patent's interictal EEGs on admission showed left posterior temporal- parietal spikes during wakefulness and frequent diffuse spike-waves during sleep. In the process of introduction and increase in the dosage of @entity8 , an aggravation of @entity2 discharges, especially a dramatic increase in diffuse spike-waves during sleep, was observed. In the same period of time, @entity3 not followed by @entity9 newly appeared, and there was an increase in the frequency of @entity3 and combined @entity3 . Marked improvement of @entity2 discharges, namely the disappearance of diffuse discharges, and complete suppression of all types of @entity3 were achieved by the introduction of @entity6 ( @entity7 ) along with the withdrawal of @entity8 . During the clinical course, the @entity0 did not display any signs or symptoms of @entity8 @entity1 , @entity5 of @entity8 or metabolic aberration. The paradoxical effect of @entity7 in localization-related @entity2 is well-known, yet in this case, @entity8 displayed a similar paradoxical effect. Additionally, @entity7 was efficacious in the suppression of secondary bilateral synchrony on EEG and also successfully controlled @entity3 , combined @entity3 and @entity3 .

title: [Aggravation of @entity2 by @entity4 in a @entity0 with cryptogenic localization-related XXXX ].

answer: @entity2


abstract: We report a paradoxical effect of @entity4 ( @entity8 ) observed in a 3-year-old @entity0 with cryptogenic localization-related @entity2 . On admission she experienced two types of @entity3 that were confirmed by ictal EEGs : @entity3 ( @entity3 ) originating from the left hemisphere and combined @entity3 that began with repetitive @entity3 immediately followed by a @entity9 . These @entity3 did not possess asymmetrical features, but the ictal EEGs showed left-side dominant multiple spike-waves. The patent's interictal EEGs on admission showed left posterior temporal- parietal spikes during wakefulness and frequent diffuse spike-waves during sleep. In the process of introduction and increase in the dosage of @entity8 , an aggravation of @entity2 discharges, especially a dramatic increase in diffuse spike-waves during sleep, was observed. In the same period of time, @entity3 not followed by @entity9 newly appeared, and there was an increase in the frequency of @entity3 and combined @entity3 . Marked improvement of @entity2 discharges, namely the disappearance of diffuse discharges, and complete suppression of all types of @entity3 were achieved by the introduction of @entity6 ( @entity7 ) along with the withdrawal of @entity8 . During the clinical course, the @entity0 did not display any signs or symptoms of @entity8 @entity1 , @entity5 of @entity8 or metabolic aberration. The paradoxical effect of @entity7 in localization-related @entity2 is well-known, yet in this case, @entity8 displayed a similar paradoxical effect. Additionally, @entity7 was efficacious in the suppression of secondary bilateral synchrony on EEG and also successfully controlled @entity3 , combined @entity3 and @entity3 .

title: [Aggravation of @entity2 by @entity4 in a XXXX with cryptogenic localization-related @entity2 ].

answer: @entity0


abstract: Cervical connective tissue was obtained from non pregnant fertile @entity0 undergoing hysterectomy. Tissue specimens were mechanically chopped into 1 mm thick slices which were preincubated in Krebs-Ringer @entity7 buffer containing @entity4 or PGF2 alpha (300 ng/ml). After 60 min the slices were transferred into fresh buffer with the corresponding PG-concentration and 3H-labelled @entity5 or @entity3 . Following incubation (60 min) the protein bound radioactivity was determined and related either to the dry weight or to the protein content of each slice. The two methods used did not show any qualitative differences. The experiments showed that PG:s had a marked effect on protein synthesis in the cervical tissue. During the follicular phase incubation with both types of PG:s was followed by a decreased incorporation indicating decreased net synthesis of collagen while there was an increased incorporation and hence increased synthesis in the luteal phase. There was no significant influence on the distribution of the model @entity2 @entity8 -AIB in the presence of PG:s neither in the follicular nor in the luteal phase. The present data point to an acute effect of @entity4 and PGF2 alpha on cervical collagen metabolism and indicate furthermore that the process is @entity1 hormone dependent. It is concluded that these substances may exert their effect by modulating the incorporation of @entity6 into protein.

title: The regulatory influence of prostaglandins on protein synthesis in the XXXX non pregnant cervix.

answer: @entity0


abstract: Voiding synchronous cystosphincterometry with uroflowmetry was used in 16 @entity0 with traumatic cervical @entity2 to evaluate bladder recovery. This method was shown to be reliable since the statistical analysis of the voiding responses showed the same values with repeated tests. A total of 14 @entity0 with such injuries recovered from shock in 6 weeks and 10 acquired mature @entity1 with a synergic external sphincteric urethra approximately 13 weeks after @entity2 . Bladders in @entity0 with cervical @entity2 usually recover from a state of inactive detrusor to that of a mature contraction by way of immature small and/or sustained contractions. Pressure measurements revealed 7.1 plus or minus 3.7 cm. water in the empty bladder and 74 plus or minus 20.5 cm. water (43 plus or minus 13.3 seconds in duration) in the recovered @entity1 . Resting pressure in the external sphincteric urethra was 70 plus or minus 25.3 cm. water. The dyssynergic sphincter coexists with immature sustained @entity1 and it usually improves to the synergic state, according to the degree of maturity of @entity1 . The bladder and external urethral sphincter recover independently and a synergic response develops even in cases of complete lesions. Thus, synergy can be accomplished by regulatory mechanisms at the sacral cord level. Surgical intervention should be postponed if the maturity of @entity1 is not yet established. More precise objective information in the @entity1 caused by cervical @entity2 can be obtained when voiding synchronous cystosphincterometry with uroflowmetry is used.

title: Bladder recovery in @entity0 with traumatic cervical XXXX evaluated by voiding synchronous cystosphincterometry with uroflowmetry.

answer: @entity2


abstract: Voiding synchronous cystosphincterometry with uroflowmetry was used in 16 @entity0 with traumatic cervical @entity2 to evaluate bladder recovery. This method was shown to be reliable since the statistical analysis of the voiding responses showed the same values with repeated tests. A total of 14 @entity0 with such injuries recovered from shock in 6 weeks and 10 acquired mature @entity1 with a synergic external sphincteric urethra approximately 13 weeks after @entity2 . Bladders in @entity0 with cervical @entity2 usually recover from a state of inactive detrusor to that of a mature contraction by way of immature small and/or sustained contractions. Pressure measurements revealed 7.1 plus or minus 3.7 cm. water in the empty bladder and 74 plus or minus 20.5 cm. water (43 plus or minus 13.3 seconds in duration) in the recovered @entity1 . Resting pressure in the external sphincteric urethra was 70 plus or minus 25.3 cm. water. The dyssynergic sphincter coexists with immature sustained @entity1 and it usually improves to the synergic state, according to the degree of maturity of @entity1 . The bladder and external urethral sphincter recover independently and a synergic response develops even in cases of complete lesions. Thus, synergy can be accomplished by regulatory mechanisms at the sacral cord level. Surgical intervention should be postponed if the maturity of @entity1 is not yet established. More precise objective information in the @entity1 caused by cervical @entity2 can be obtained when voiding synchronous cystosphincterometry with uroflowmetry is used.

title: Bladder recovery in XXXX with traumatic cervical @entity2 evaluated by voiding synchronous cystosphincterometry with uroflowmetry.

answer: @entity0


abstract: Eleven pediatric @entity5 @entity0 underwent surgery. Four had left, 5 right cardiac type and 2 had @entity5 . Two @entity0 had 2 accessory conduction pathways (ACP). @entity7 and secundum type @entity1 were the association @entity2 in one @entity0 each. Indications for surgery included repeated and/or long-lasting @entity6 ( @entity6 ), ineffective drug therapy, @entity4 due to frequent @entity3 , short effective refractory period of the ACP, and simultaneous surgery for associated @entity2 . Pre- and intra-operative examinations, including ECG, VCG, UCG, body surface mapping, intracavitary recording by catheter electrodes, computerized epicardial mapping, and endocardial mapping, were performed for the precise localization of the ACP. The surgical method was basically the same as is used for adults. Anterior median stermotomy was used primarily in right cardiac and right septal type and left anterior thoracotomy was used in 3 of 4 cases of the left cardiac type. Eight of 11 cases, two of which had 3 ACPs, were completely cured and in 3 there was evidence of postoperative pre-excitation. However, the @entity6 attacks disappeared almost completely and drug therapy is not required at present.

title: Surgical treatment of the XXXX in @entity0 and @entity0 .

answer: @entity5


abstract: Eleven pediatric @entity5 @entity0 underwent surgery. Four had left, 5 right cardiac type and 2 had @entity5 . Two @entity0 had 2 accessory conduction pathways (ACP). @entity7 and secundum type @entity1 were the association @entity2 in one @entity0 each. Indications for surgery included repeated and/or long-lasting @entity6 ( @entity6 ), ineffective drug therapy, @entity4 due to frequent @entity3 , short effective refractory period of the ACP, and simultaneous surgery for associated @entity2 . Pre- and intra-operative examinations, including ECG, VCG, UCG, body surface mapping, intracavitary recording by catheter electrodes, computerized epicardial mapping, and endocardial mapping, were performed for the precise localization of the ACP. The surgical method was basically the same as is used for adults. Anterior median stermotomy was used primarily in right cardiac and right septal type and left anterior thoracotomy was used in 3 of 4 cases of the left cardiac type. Eight of 11 cases, two of which had 3 ACPs, were completely cured and in 3 there was evidence of postoperative pre-excitation. However, the @entity6 attacks disappeared almost completely and drug therapy is not required at present.

title: Surgical treatment of the @entity5 in XXXX and @entity0 .

answer: @entity0


abstract: Eleven pediatric @entity5 @entity0 underwent surgery. Four had left, 5 right cardiac type and 2 had @entity5 . Two @entity0 had 2 accessory conduction pathways (ACP). @entity7 and secundum type @entity1 were the association @entity2 in one @entity0 each. Indications for surgery included repeated and/or long-lasting @entity6 ( @entity6 ), ineffective drug therapy, @entity4 due to frequent @entity3 , short effective refractory period of the ACP, and simultaneous surgery for associated @entity2 . Pre- and intra-operative examinations, including ECG, VCG, UCG, body surface mapping, intracavitary recording by catheter electrodes, computerized epicardial mapping, and endocardial mapping, were performed for the precise localization of the ACP. The surgical method was basically the same as is used for adults. Anterior median stermotomy was used primarily in right cardiac and right septal type and left anterior thoracotomy was used in 3 of 4 cases of the left cardiac type. Eight of 11 cases, two of which had 3 ACPs, were completely cured and in 3 there was evidence of postoperative pre-excitation. However, the @entity6 attacks disappeared almost completely and drug therapy is not required at present.

title: Surgical treatment of the @entity5 in @entity0 and XXXX .

answer: @entity0


abstract: Subjective quality of life (QoL) and psychosocial functioning constitute important treatment outcomes in @entity1 . We aimed to investigate the relationship between them in @entity1 @entity0 living in the community. Symptom severity and insight were assessed with the Positive and Negative Syndrome Scale (PANSS) in 76 community @entity1 @entity0 . Social functioning was measured with the Portuguese version of @entity2 ( @entity2 ) scale, and subjective QoL was measured with the Portuguese version of the WHO Quality of Life Measure-Abbreviated Version (WHOQOL-Bref). The majority of @entity0 were single (78%) and unemployed/inactive (74%). Mean @entity2 total score was 55.5, and mean scores on WHOQOL-Bref domains ranged from 54.1 to 63.0. Greater symptom severity and worse insight were significantly associated with worse functioning in all @entity2 domains. Symptoms were more moderately correlated with QoL, with no significant correlations between QoL and positive symptoms and insight levels. Partial correlations controlling for symptom severity revealed no significant associations between social functioning and subjective QoL. Symptom severity may exert a greater influence on social functioning than on subjective QoL; however, social functioning was not associated with subjective QoL. The results suggest these constructs might be independent and should be assessed separately. A broader research approach, with increased attention to social and psychological factors, may help identify treatment targets to improve @entity1 @entity0 ' social functioning and QoL.

title: Is personal and social functioning associated with subjective quality of life in XXXX @entity0 living in the community?

answer: @entity1


abstract: Subjective quality of life (QoL) and psychosocial functioning constitute important treatment outcomes in @entity1 . We aimed to investigate the relationship between them in @entity1 @entity0 living in the community. Symptom severity and insight were assessed with the Positive and Negative Syndrome Scale (PANSS) in 76 community @entity1 @entity0 . Social functioning was measured with the Portuguese version of @entity2 ( @entity2 ) scale, and subjective QoL was measured with the Portuguese version of the WHO Quality of Life Measure-Abbreviated Version (WHOQOL-Bref). The majority of @entity0 were single (78%) and unemployed/inactive (74%). Mean @entity2 total score was 55.5, and mean scores on WHOQOL-Bref domains ranged from 54.1 to 63.0. Greater symptom severity and worse insight were significantly associated with worse functioning in all @entity2 domains. Symptoms were more moderately correlated with QoL, with no significant correlations between QoL and positive symptoms and insight levels. Partial correlations controlling for symptom severity revealed no significant associations between social functioning and subjective QoL. Symptom severity may exert a greater influence on social functioning than on subjective QoL; however, social functioning was not associated with subjective QoL. The results suggest these constructs might be independent and should be assessed separately. A broader research approach, with increased attention to social and psychological factors, may help identify treatment targets to improve @entity1 @entity0 ' social functioning and QoL.

title: Is personal and social functioning associated with subjective quality of life in @entity1 XXXX living in the community?

answer: @entity0


abstract: PURPOSE: Our aim was to determine the most effective surgical procedure for treatment of @entity2 , by comparing different surgical techniques. METHODS: A total of 354 @entity0 who underwent operation for @entity2 were enrolled in this prospective study. The data included @entity0 's demographic characteristics, age, gender, body mass index, occupation, smoking, concomitant diseases, surgeon's experience, wound-healing problems (wound separation and @entity3 ), time to return to work, and development of recurrence. RESULTS: Of the 354 @entity0 , total excision   +   primary closure was performed in 133 (37.6%), D-flap in 101 (28.5%), Karydakis technique in 74 (20.9%), and Limberg flap surgery in 46 (13%). The male/female ratio was 8.5:1, which is a statistically significant difference (p   <   0.05). The average follow-up period was 37  months (range, 12-97  months); during this period, wound-healing problems were observed in 70 (19.7%) @entity0 , and 34 (9.6%) @entity0 developed recurrence. There was no difference in the rate of recurrence of @entity2 between procedures done by trainees and staff surgeons. Recurrence rates were similar for all four treatment methods (7.5-13.5%). Wound-healing problems were higher for D-flap than for other methods (p   =   0.027). The average time to return to work with the D-flap method was longer than that for the other methods (p   <   0.01). Recurrence increased 14.44-fold following the development of @entity4 . Higher recurrence rates were also noted in @entity1 @entity0 (8.10-fold) and in females (6.72-fold). CONCLUSIONS: Despite the increasing volume of data on the treatment of @entity2 , the optimal treatment has yet to be established.

title: Which surgical procedure offers the best treatment for XXXX ?

answer: @entity2


abstract: OBJECTIVE: @entity6 is an important cause of @entity2 in @entity0 with @entity4 ( @entity4 ). Evidence suggests that immune mechanisms contribute to @entity3 and @entity1 , leading to @entity7 ( @entity7 ). The purpose of this study was to identify a signature of @entity7 in @entity0 with @entity4 by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo. METHODS: @entity4 @entity0 (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild @entity7 , or moderate-to-severe @entity7 . The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. @entity8 models were used to test for associations between a multicytokine immune response score and @entity7 , after adjusting for clinical covariates. RESULTS: An 11-cytokine profile effectively differentiated @entity0 with moderate-to-severe @entity7 from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe @entity7 (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum @entity5 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other @entity4 characteristics and @entity7 risk factors. CONCLUSION: The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced @entity3 in @entity0 with @entity4 . The unique information added by the immune response score concerning the likelihood of @entity7 warrants future longitudinal studies of its value in predicting @entity9 in myocardial function.

title: A signature of aberrant immune responsiveness identifies XXXX in @entity4 .

answer: @entity3


abstract: OBJECTIVE: @entity6 is an important cause of @entity2 in @entity0 with @entity4 ( @entity4 ). Evidence suggests that immune mechanisms contribute to @entity3 and @entity1 , leading to @entity7 ( @entity7 ). The purpose of this study was to identify a signature of @entity7 in @entity0 with @entity4 by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo. METHODS: @entity4 @entity0 (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild @entity7 , or moderate-to-severe @entity7 . The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. @entity8 models were used to test for associations between a multicytokine immune response score and @entity7 , after adjusting for clinical covariates. RESULTS: An 11-cytokine profile effectively differentiated @entity0 with moderate-to-severe @entity7 from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe @entity7 (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum @entity5 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other @entity4 characteristics and @entity7 risk factors. CONCLUSION: The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced @entity3 in @entity0 with @entity4 . The unique information added by the immune response score concerning the likelihood of @entity7 warrants future longitudinal studies of its value in predicting @entity9 in myocardial function.

title: A signature of aberrant immune responsiveness identifies @entity3 in XXXX .

answer: @entity4


abstract: BACKGROUND: @entity2 is a rare, locally aggressive @entity1 most commonly occurring on the face. Minimal data are available regarding the role of @entity3 ( @entity3 ). METHODS: Cases treated with @entity3 from 2 comprehensive @entity1 centers are reviewed along with a review of the literature. RESULTS: Three @entity0 with @entity2 of the face were treated with curative intent. One @entity0 received @entity3 as monotherapy. Two @entity0 received postoperative @entity3 (PORT). The @entity0 receiving @entity3 as monotherapy experienced excellent clinical regression, had an in-field recurrence at 48-month follow-up, and is now without evidence of disease after reirradiation. Both @entity0 receiving PORT are without evidence of disease. CONCLUSION: PORT may improve local control in @entity0 with @entity2 , and its use should be considered in @entity0 with high-risk features for local recurrence. @entity3 as monotherapy should be considered when poor cosmetic outcome can be anticipated via standard surgical treatments.

title: XXXX of the face treated with @entity3 : a case report and review of the literature.

answer: @entity2


abstract: BACKGROUND: @entity2 is a rare, locally aggressive @entity1 most commonly occurring on the face. Minimal data are available regarding the role of @entity3 ( @entity3 ). METHODS: Cases treated with @entity3 from 2 comprehensive @entity1 centers are reviewed along with a review of the literature. RESULTS: Three @entity0 with @entity2 of the face were treated with curative intent. One @entity0 received @entity3 as monotherapy. Two @entity0 received postoperative @entity3 (PORT). The @entity0 receiving @entity3 as monotherapy experienced excellent clinical regression, had an in-field recurrence at 48-month follow-up, and is now without evidence of disease after reirradiation. Both @entity0 receiving PORT are without evidence of disease. CONCLUSION: PORT may improve local control in @entity0 with @entity2 , and its use should be considered in @entity0 with high-risk features for local recurrence. @entity3 as monotherapy should be considered when poor cosmetic outcome can be anticipated via standard surgical treatments.

title: @entity2 of the face treated with XXXX : a case report and review of the literature.

answer: @entity3


abstract: We report a 78-year-old @entity0 who had episodes of @entity1 ( @entity1 ) with @entity5 . At 75 years of age, she had first @entity3 , but was not well examined. At 78 years of age, she had brief myoclonic jerks of her arms, soon after awakening, in May. She suffered from strong @entity5 and was admitted in our hospital at the end of June. The symptoms regressed with bed rest in few days and she was discharged. However, she was admitted again with @entity5 in the middle of July. There were no myoclonic jerks of her arms or legs and she could converse and interact normally, but was slightly disoriented (JCS: 2). Blood test, Cerebrospinal fluid analyses and brain MRI were normal. An EEG showed frequent intermittent generalized multiple spikes and slow wave complexes and a 3-4 Hz generalized spike and slow wave complexes every 2-4 seconds during whole 20 minutes record. Intravenous injection of 5 mg @entity6 terminated status immediately. Thereafter, she was treated with @entity4 (400 mg/day). Her symptoms improved, and interictal @entity2 discharges extremely decreased. Late-onset @entity1 of @entity7 is rare. We discussed this case as an important case for diagnosis of @entity1 with subtle symptom of @entity5 .

title: [A late-onset case of XXXX of @entity7 ].

answer: @entity1


abstract: We report a 78-year-old @entity0 who had episodes of @entity1 ( @entity1 ) with @entity5 . At 75 years of age, she had first @entity3 , but was not well examined. At 78 years of age, she had brief myoclonic jerks of her arms, soon after awakening, in May. She suffered from strong @entity5 and was admitted in our hospital at the end of June. The symptoms regressed with bed rest in few days and she was discharged. However, she was admitted again with @entity5 in the middle of July. There were no myoclonic jerks of her arms or legs and she could converse and interact normally, but was slightly disoriented (JCS: 2). Blood test, Cerebrospinal fluid analyses and brain MRI were normal. An EEG showed frequent intermittent generalized multiple spikes and slow wave complexes and a 3-4 Hz generalized spike and slow wave complexes every 2-4 seconds during whole 20 minutes record. Intravenous injection of 5 mg @entity6 terminated status immediately. Thereafter, she was treated with @entity4 (400 mg/day). Her symptoms improved, and interictal @entity2 discharges extremely decreased. Late-onset @entity1 of @entity7 is rare. We discussed this case as an important case for diagnosis of @entity1 with subtle symptom of @entity5 .

title: [A late-onset case of @entity1 of XXXX ].

answer: @entity7


abstract: OBJECTIVE: The objective of this study is to explore the sensitivity to intermodal asynchrony in audiovisual speech with moderate to severe @entity2 . Based on previous studies, two opposing expectations were an increase in sensitivity, as @entity1 listeners heavily rely on lipreading in daily life, and a reduction in sensitivity, as @entity1 listeners tend to be elderly and advanced age could potentially impair audiovisual integration. DESIGN: Adults with normal (N = 11, ages between 23 and 50 yrs) and impaired hearing (N = 11, ages between 54 and 81 yrs, the pure-tone average between 42 and 67 dB @entity3 ) participated in two experiments. In the first experiment, the synchrony judgments were recorded for varying intermodal time differences in audiovisual sentence recordings. In the second experiment, the intelligibility of audiovisual and audio-only speech was measured in speech-shaped noise, and correlations were explored between the synchrony window and intelligibility scores for individual listeners. RESULTS: Similar to previous studies, a sensitivity window on the order of a few hundred milliseconds was observed with all listeners. The average window shapes did not differ between normal-hearing and @entity1 groups; however, there was large individual variability. Individual windows were quantified by Gaussian curve fitting. Point of subjective simultaneity, a measure of window peak shift from the actual synchrony point, and full-width at half-maximum, a measure of window duration, were not correlated with @entity0 's age or the degree of @entity1 . Points of subjective simultaneity were also not correlated with speech intelligibility scores. A moderate negative correlation that was significant at most conditions was observed between the full-width at half-maximum values and intelligibility scores. CONCLUSIONS: Contrary to either expectation per se, there was no indication of an effect of @entity1 or age on the sensitivity to intermodal asynchrony in audiovisual speech. It is possible that the negative effects of aging were balanced with the positive effects of increased sensitivity due to reliance on visual cues with @entity1 . The listeners, normal hearing or @entity1 , who were more sensitive to asynchrony (with narrower synchrony windows) tended to understand speech in noise better, with both audio-only and audiovisual speech. The practical implication of the results is that delays in audio or video signals of communication systems would affect @entity1 listeners in a manner similar to normal-hearing listeners, and due to the importance of visual cues for the @entity1 listeners, special attention should be given to limit these delays.

title: Audiovisual asynchrony detection and speech intelligibility in noise with moderate to severe XXXX .

answer: @entity2


abstract: BACKGROUND: @entity3 is widely used for cesarean section due to the rapid induction, the complete @entity6 , the low failure rate and the prevention of @entity5 . The addition of intrathecal opioids to local anesthetics seems to improve the quality of @entity6 _ prolong the duration of @entity6 . Therefore we compared the effects of @entity8 20   g and @entity4 2.5   g, which were added to intrathecal hyperbaric @entity7 . METHODS: SEVENTY TWO HEALTHY TERM PARTURIENTS WERE RANDOMLY DIVIDED INTO THREE GROUPS: Group C (control), Group F ( @entity8 20   g) and Group S ( @entity4 2.5   g). In every group, 0.5% heavy @entity7 was added according to the adjusted dose regimen by Harten et al. We observed the maximal level of the sensory block and motor block, the quality of intraoperative @entity6 , the duration of effective @entity6 and the side effects. RESULTS: There were significant differences between the control and the @entity8 20   g and @entity4 2.5   g groups for the degree of @entity1 , the quality of intraoperative @entity6 , the maximal sedation level and the duration of effective @entity6 . The frequencies of side effects such as @entity2 and @entity0 in the opioid groups were higher than those in the control group. But there were no differences between @entity8 20   g and @entity4 2.5   g for the frequencies of @entity2 and @entity0 . CONCLUSIONS: The addition of @entity8 20   g or @entity4 2.5   g for spinal anesthesia provides adequate intraoperative @entity6 without significant adverse effects on the mother and neonate.

title: Comparison of @entity8 and @entity4 added to 0.5% hyperbaric XXXX for spinal anesthesia in patients undergoing cesarean section.

answer: @entity7


abstract: BACKGROUND: @entity3 is widely used for cesarean section due to the rapid induction, the complete @entity6 , the low failure rate and the prevention of @entity5 . The addition of intrathecal opioids to local anesthetics seems to improve the quality of @entity6 _ prolong the duration of @entity6 . Therefore we compared the effects of @entity8 20   g and @entity4 2.5   g, which were added to intrathecal hyperbaric @entity7 . METHODS: SEVENTY TWO HEALTHY TERM PARTURIENTS WERE RANDOMLY DIVIDED INTO THREE GROUPS: Group C (control), Group F ( @entity8 20   g) and Group S ( @entity4 2.5   g). In every group, 0.5% heavy @entity7 was added according to the adjusted dose regimen by Harten et al. We observed the maximal level of the sensory block and motor block, the quality of intraoperative @entity6 , the duration of effective @entity6 and the side effects. RESULTS: There were significant differences between the control and the @entity8 20   g and @entity4 2.5   g groups for the degree of @entity1 , the quality of intraoperative @entity6 , the maximal sedation level and the duration of effective @entity6 . The frequencies of side effects such as @entity2 and @entity0 in the opioid groups were higher than those in the control group. But there were no differences between @entity8 20   g and @entity4 2.5   g for the frequencies of @entity2 and @entity0 . CONCLUSIONS: The addition of @entity8 20   g or @entity4 2.5   g for spinal anesthesia provides adequate intraoperative @entity6 without significant adverse effects on the mother and neonate.

title: Comparison of @entity8 and XXXX added to 0.5% hyperbaric @entity7 for spinal anesthesia in patients undergoing cesarean section.

answer: @entity4


abstract: BACKGROUND: @entity3 is widely used for cesarean section due to the rapid induction, the complete @entity6 , the low failure rate and the prevention of @entity5 . The addition of intrathecal opioids to local anesthetics seems to improve the quality of @entity6 _ prolong the duration of @entity6 . Therefore we compared the effects of @entity8 20   g and @entity4 2.5   g, which were added to intrathecal hyperbaric @entity7 . METHODS: SEVENTY TWO HEALTHY TERM PARTURIENTS WERE RANDOMLY DIVIDED INTO THREE GROUPS: Group C (control), Group F ( @entity8 20   g) and Group S ( @entity4 2.5   g). In every group, 0.5% heavy @entity7 was added according to the adjusted dose regimen by Harten et al. We observed the maximal level of the sensory block and motor block, the quality of intraoperative @entity6 , the duration of effective @entity6 and the side effects. RESULTS: There were significant differences between the control and the @entity8 20   g and @entity4 2.5   g groups for the degree of @entity1 , the quality of intraoperative @entity6 , the maximal sedation level and the duration of effective @entity6 . The frequencies of side effects such as @entity2 and @entity0 in the opioid groups were higher than those in the control group. But there were no differences between @entity8 20   g and @entity4 2.5   g for the frequencies of @entity2 and @entity0 . CONCLUSIONS: The addition of @entity8 20   g or @entity4 2.5   g for spinal anesthesia provides adequate intraoperative @entity6 without significant adverse effects on the mother and neonate.

title: Comparison of XXXX and @entity4 added to 0.5% hyperbaric @entity7 for spinal anesthesia in patients undergoing cesarean section.

answer: @entity8


abstract: BACKGROUND: Spasticity is a common @entity1 with adverse effects on the @entity0 's function. Conservative management is unsuccessful in a significant proportion of @entity0 and neurosurgical intervention should be considered. The mainstay of surgical treatment of @entity3 is selective posterior rhizotomy, i.e., section of sensory nerve roots of the cauda equina. OBJECTIVE: To report our experience with selective posterior rhizotomy in the treatment of @entity3 . METHODS: We retrospectively reviewed our experience in 154 @entity0 who underwent @entity6 during 30 years. The indication for surgery was @entity3 that significantly hindered the @entity0 's function or care and was resistant to conservative treatment. All @entity0 were evaluated for @entity3 in the lower and upper limbs, the presence or absence of @entity2 , and sphincter disturbances. The decision as to which roots to be sectioned, and to what extent, was based mainly on clinical muscle testing. RESULTS: Reduction of @entity3 in the lower limbs was obtained in every case, with improvement in movements in 86% of cases. Painful @entity5 were alleviated in 80% of cases. @entity4 was observed in 42%. A minority of the @entity0 also showed improvement in speech and cognitive performance. There was no perioperative mortality or major complications. CONCLUSION: @entity6 is a safe and effective method for the treatment of @entity3 with long-lasting beneficial effects. We suggest that this method be considered more frequently for @entity0 with @entity3 that interferes with their quality of life.

title: Surgical treatment of XXXX by selective posterior rhizotomy: 30 years experience.

answer: @entity3