abstract: @entity8 inhibits release of @entity9 ( @entity9 ) and @entity2 (OT) from the hypothalamo-neurohypophysial system during @entity7 . We investigated whether opioid peptides mediate the inhibitory effect of water on secretion of these hormones. Conscious male @entity0 were made @entity7 by @entity3 ( @entity3 , 0.51 ml/min) of 20 and 35% of the blood volume or by injection of either subcutaneous @entity4 ( @entity5 , 20,000 mol wt, 35 ml/kg) or intraperitoneal @entity1 (HIS, 15 mg/kg, 1 ml/kg). Animals were intubated orally 1-4 min ( @entity3 , HIS) or 6.75 h ( @entity5 ) later with or without administration of water (40 ml/kg). Four to seven min after intubation @entity0 were injected with saline (1 ml/kg) or @entity6 (2 or 5 mg/kg) and then decapitated 6-10 min later. Control animals were treated similarly but were not stimulated by @entity7 . @entity9 and OT were extracted from plasma and quantified by radioimmunoassay. Data were analyzed by analysis of variance. In @entity3 animals blood pressure fell and plasma osmolality increased, both of which correlated positively with the rise in plasma [ @entity9 ] and [OT]. @entity8 lowered the plasma osmolality, attenuated the fall in blood pressure, and reduced [ @entity9 ] and [OT] in plasma of @entity3 animals. The opiate receptor antagonist, @entity6 , did not alter these changes in blood pressure or plasma osmolality, or the plasma [ @entity9 ] after @entity3 in @entity0 treated with or without water. Plasma [OT] was, however, increased by @entity6 in both normally hydrated and overhydrated @entity0 . Thus, regardless of the hydrational state of the animal, opioid peptides inhibited release of OT but not @entity9 during @entity3 . Data consistent with this interpretation were also obtained from @entity0 made @entity7 with @entity5 or HIS.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Inhibition of XXXX and OT release by water in @entity7 is independent of opioid peptides.

answer: @entity9


abstract: @entity8 inhibits release of @entity9 ( @entity9 ) and @entity2 (OT) from the hypothalamo-neurohypophysial system during @entity7 . We investigated whether opioid peptides mediate the inhibitory effect of water on secretion of these hormones. Conscious male @entity0 were made @entity7 by @entity3 ( @entity3 , 0.51 ml/min) of 20 and 35% of the blood volume or by injection of either subcutaneous @entity4 ( @entity5 , 20,000 mol wt, 35 ml/kg) or intraperitoneal @entity1 (HIS, 15 mg/kg, 1 ml/kg). Animals were intubated orally 1-4 min ( @entity3 , HIS) or 6.75 h ( @entity5 ) later with or without administration of water (40 ml/kg). Four to seven min after intubation @entity0 were injected with saline (1 ml/kg) or @entity6 (2 or 5 mg/kg) and then decapitated 6-10 min later. Control animals were treated similarly but were not stimulated by @entity7 . @entity9 and OT were extracted from plasma and quantified by radioimmunoassay. Data were analyzed by analysis of variance. In @entity3 animals blood pressure fell and plasma osmolality increased, both of which correlated positively with the rise in plasma [ @entity9 ] and [OT]. @entity8 lowered the plasma osmolality, attenuated the fall in blood pressure, and reduced [ @entity9 ] and [OT] in plasma of @entity3 animals. The opiate receptor antagonist, @entity6 , did not alter these changes in blood pressure or plasma osmolality, or the plasma [ @entity9 ] after @entity3 in @entity0 treated with or without water. Plasma [OT] was, however, increased by @entity6 in both normally hydrated and overhydrated @entity0 . Thus, regardless of the hydrational state of the animal, opioid peptides inhibited release of OT but not @entity9 during @entity3 . Data consistent with this interpretation were also obtained from @entity0 made @entity7 with @entity5 or HIS.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Inhibition of @entity9 and OT release by water in XXXX is independent of opioid peptides.

answer: @entity7


abstract: OBJECTIVE: To determine the prevalence and effect of @entity1 @entity8 in ambulatory @entity0 with stable, optimally treated @entity5 . DESIGN: A prospective, longitudinal study. SETTING: Referral sleep laboratory of a Department of Veterans Affairs medical center. @entity0 : 42 of the 48 eligible @entity0 with stable @entity5 and @entity7 (left ventricular ejection fraction < or = 45%). MEASUREMENTS: After an adaptation night, polysomnography and Holter monitoring were done in the sleep laboratory. Arterial blood gases and pH were measured, and cardiac radionuclide ventriculography and pulmonary, renal, and thyroid function tests were done. RESULTS: @entity0 were divided into two groups. Group I (n = 23) had an hourly rate of @entity3 and @entity4 ( @entity3 - @entity4 index) of 20 episodes per hour or less; group II (n = 19 [45%; CI, 30% to 60%]) had an index of more than 20 episodes per hour. In group II, the index varied from 26.5 to 82.2 episodes per hour (mean +/- SD, 44 +/- 13 episodes per hour; CI, 38 to 51 episodes per hour). Group II had significantly more arousals (24 +/- 12 compared with 3 +/- 3 in group I) that were directly attributable to episodes of @entity3 and @entity4 , longer periods of time with an arterial @entity9 saturation of less than 90% (23% +/- 24% of total sleep time compared with 2% +/- 4%), lower arterial oxyhemoglobin saturation during sleep (74% +/- 13% compared with 87% +/- 4%), lower left ventricular ejection fraction (22% +/- 9% compared with 30% +/- 10%), and a significantly increased number of episodes of nocturnal @entity6 . Multiple regression analyses showed that @entity7 was an independent risk factor for @entity4 in @entity0 with @entity5 . CONCLUSIONS: The prevalence of severe occult @entity1 @entity8 is high in ambulatory @entity0 with stable, optimally treated chronic @entity5 . The @entity8 episodes are associated with severe nocturnal arterial blood oxyhemoglobin desaturation and excessive arousals. Severe untreated @entity1 @entity8 may adversely affect left ventricular function, resulting in a vicious cycle that could contribute to @entity2 in @entity0 with @entity5 . Prospective, longitudinal studies on survival are needed.

title: Occult @entity1 @entity8 in stable XXXX .

answer: @entity5


abstract: OBJECTIVE: To determine the prevalence and effect of @entity1 @entity8 in ambulatory @entity0 with stable, optimally treated @entity5 . DESIGN: A prospective, longitudinal study. SETTING: Referral sleep laboratory of a Department of Veterans Affairs medical center. @entity0 : 42 of the 48 eligible @entity0 with stable @entity5 and @entity7 (left ventricular ejection fraction < or = 45%). MEASUREMENTS: After an adaptation night, polysomnography and Holter monitoring were done in the sleep laboratory. Arterial blood gases and pH were measured, and cardiac radionuclide ventriculography and pulmonary, renal, and thyroid function tests were done. RESULTS: @entity0 were divided into two groups. Group I (n = 23) had an hourly rate of @entity3 and @entity4 ( @entity3 - @entity4 index) of 20 episodes per hour or less; group II (n = 19 [45%; CI, 30% to 60%]) had an index of more than 20 episodes per hour. In group II, the index varied from 26.5 to 82.2 episodes per hour (mean +/- SD, 44 +/- 13 episodes per hour; CI, 38 to 51 episodes per hour). Group II had significantly more arousals (24 +/- 12 compared with 3 +/- 3 in group I) that were directly attributable to episodes of @entity3 and @entity4 , longer periods of time with an arterial @entity9 saturation of less than 90% (23% +/- 24% of total sleep time compared with 2% +/- 4%), lower arterial oxyhemoglobin saturation during sleep (74% +/- 13% compared with 87% +/- 4%), lower left ventricular ejection fraction (22% +/- 9% compared with 30% +/- 10%), and a significantly increased number of episodes of nocturnal @entity6 . Multiple regression analyses showed that @entity7 was an independent risk factor for @entity4 in @entity0 with @entity5 . CONCLUSIONS: The prevalence of severe occult @entity1 @entity8 is high in ambulatory @entity0 with stable, optimally treated chronic @entity5 . The @entity8 episodes are associated with severe nocturnal arterial blood oxyhemoglobin desaturation and excessive arousals. Severe untreated @entity1 @entity8 may adversely affect left ventricular function, resulting in a vicious cycle that could contribute to @entity2 in @entity0 with @entity5 . Prospective, longitudinal studies on survival are needed.

title: Occult XXXX @entity8 in stable @entity5 .

answer: @entity1


abstract: OBJECTIVE: To determine the prevalence and effect of @entity1 @entity8 in ambulatory @entity0 with stable, optimally treated @entity5 . DESIGN: A prospective, longitudinal study. SETTING: Referral sleep laboratory of a Department of Veterans Affairs medical center. @entity0 : 42 of the 48 eligible @entity0 with stable @entity5 and @entity7 (left ventricular ejection fraction < or = 45%). MEASUREMENTS: After an adaptation night, polysomnography and Holter monitoring were done in the sleep laboratory. Arterial blood gases and pH were measured, and cardiac radionuclide ventriculography and pulmonary, renal, and thyroid function tests were done. RESULTS: @entity0 were divided into two groups. Group I (n = 23) had an hourly rate of @entity3 and @entity4 ( @entity3 - @entity4 index) of 20 episodes per hour or less; group II (n = 19 [45%; CI, 30% to 60%]) had an index of more than 20 episodes per hour. In group II, the index varied from 26.5 to 82.2 episodes per hour (mean +/- SD, 44 +/- 13 episodes per hour; CI, 38 to 51 episodes per hour). Group II had significantly more arousals (24 +/- 12 compared with 3 +/- 3 in group I) that were directly attributable to episodes of @entity3 and @entity4 , longer periods of time with an arterial @entity9 saturation of less than 90% (23% +/- 24% of total sleep time compared with 2% +/- 4%), lower arterial oxyhemoglobin saturation during sleep (74% +/- 13% compared with 87% +/- 4%), lower left ventricular ejection fraction (22% +/- 9% compared with 30% +/- 10%), and a significantly increased number of episodes of nocturnal @entity6 . Multiple regression analyses showed that @entity7 was an independent risk factor for @entity4 in @entity0 with @entity5 . CONCLUSIONS: The prevalence of severe occult @entity1 @entity8 is high in ambulatory @entity0 with stable, optimally treated chronic @entity5 . The @entity8 episodes are associated with severe nocturnal arterial blood oxyhemoglobin desaturation and excessive arousals. Severe untreated @entity1 @entity8 may adversely affect left ventricular function, resulting in a vicious cycle that could contribute to @entity2 in @entity0 with @entity5 . Prospective, longitudinal studies on survival are needed.

title: Occult @entity1 XXXX in stable @entity5 .

answer: @entity8


abstract: OBJECTIVE: The aim of this study was to determine prescribing patterns for the pharmacological treatment of @entity1 in a sample of Argentinean psychiatrists and to compare some results with those obtained in a previous survey done on a similar population. METHODS: A self-administered survey was conducted among psychiatrists who attended a conference of psychopharmacology held in August 2012 in Buenos Aires city. Answers were analyzed descriptively and some of them were compared with results of another survey done in 2006 in a psychiatry conference. RESULTS: Ninety six percent of the surveyed psychiatrists considered that every @entity1 @entity0 with an acute episode must be pharmacologically treated. For the acute and chronic treatment of positive symptoms most psychiatrists chose @entity5 , @entity6 , @entity2 and @entity4 . In contrast, for the chronic treatment of negative symptomatology, physicians preferred @entity5 , @entity7 , @entity2 , @entity4 and @entity3 . An increased choice of @entity4 and @entity7 was observed between this survey and the previous one. Sixty four percent of respondents reported using antipsychotic combination, similar as assessed in the previous survey. Most preferred to maintain pharmacological treatment during the pregnancy, although changing the antipsychotic to @entity6 . Ninety eight percent stated that they use some kind of psychotherapy in the treatment. CONCLUSION: In the pharmacological treatment of @entity1 , similarities between reported clinical practice and current treatment guidelines were observed. There were no significant differences in the prescription patterns referred by psychiatrists between 2006 and 2012.

title: [Prescription patterns in the treatment of XXXX ].

answer: @entity1


abstract: The aim of this study was to monitor pH in 2-day-old @entity5 after administration of a long-acting, @entity3 -containing @entity4 tablet (Suscard). The tablet was placed under the lip of the maxilla. This was done both in two older subjects suffering from @entity1 and in 10 younger, healthy subjects. In the latter group, a @entity2 -containing lozenge was used as a control. The influence of a 5-wk period of daily use of Suscard (in the two elderly subjects) and the effect of normal oral hygiene procedures (in the 10 younger subjects) on the pH response was also studied. Plaque pH was measured in situ up to 1 h, at five different approximal sites in the front region of the maxilla by the micro-touch method. The Suscard tablet resulted in a @entity6 in both groups when teeth had not been brushed for 2 days. The lowest pH was recorded at the sites close to where the tablet had been placed. The most attenuated pH drop was found in the two older subjects, who showed a mean minimum pH of 5.7, as compared with 6.2 for the younger subjects. No further increase in the pH fall from Suscard was seen after the 5-wk period in the two @entity0 with @entity1 . In the 10 younger healthy subjects, the most pronounced pH decrease was registered after administration of the @entity2 -containing lozenge. The pH drop for Suscard was not significant when normal oral hygiene procedures preceded the test.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of buccal administration of a @entity3 -containing XXXX tablet (Suscard) on plaque pH.

answer: @entity4


abstract: The aim of this study was to monitor pH in 2-day-old @entity5 after administration of a long-acting, @entity3 -containing @entity4 tablet (Suscard). The tablet was placed under the lip of the maxilla. This was done both in two older subjects suffering from @entity1 and in 10 younger, healthy subjects. In the latter group, a @entity2 -containing lozenge was used as a control. The influence of a 5-wk period of daily use of Suscard (in the two elderly subjects) and the effect of normal oral hygiene procedures (in the 10 younger subjects) on the pH response was also studied. Plaque pH was measured in situ up to 1 h, at five different approximal sites in the front region of the maxilla by the micro-touch method. The Suscard tablet resulted in a @entity6 in both groups when teeth had not been brushed for 2 days. The lowest pH was recorded at the sites close to where the tablet had been placed. The most attenuated pH drop was found in the two older subjects, who showed a mean minimum pH of 5.7, as compared with 6.2 for the younger subjects. No further increase in the pH fall from Suscard was seen after the 5-wk period in the two @entity0 with @entity1 . In the 10 younger healthy subjects, the most pronounced pH decrease was registered after administration of the @entity2 -containing lozenge. The pH drop for Suscard was not significant when normal oral hygiene procedures preceded the test.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of buccal administration of a XXXX -containing @entity4 tablet (Suscard) on plaque pH.

answer: @entity3


abstract: PURPOSE: The prognosis of @entity4 ( @entity4 ) from @entity2 has been improved with @entity6 ( @entity6 ) and hyperthermic intraperitoneal chemotherapy (HIPEC). However, benefits of postoperative chemotherapy (CT) are unclear. METHODS: This retrospective, multicenter study included 231 @entity0 treated by @entity6 and HIPEC for isolated @entity4 of @entity5 in four expert's centers. Overall survival (OS), progression-free survival (PFS), and peritoneal recurrence-free survival (PRFS) were compared between @entity0 with adjuvant CT (started within 3  months after surgery) and @entity0 with surveillance only. RESULTS: After exclusion of 10 @entity0 for early postoperative @entity3 (4  %), 221 @entity0 were included (CT group: n  =  151; surveillance group: n  =  70). Main postoperative CT regimens (median of 6 cycles) were Folfox (28  %), Folfiri bevacizumab (24.5  %), Folfiri (16  %), and Folfiri cetuximab (12.5  %). The median OS after surgery was 43.3  months with no difference between CT and surveillance groups. In multivariate analysis, a low peritoneal @entity1 index (p  <  0.0001) and a long delay between diagnosis of @entity7 and HIPEC (p  =  0.001) were associated with increased OS. The median PFS and PRFS were 12.4 and 17  months, respectively. At 1  year, more @entity0 were without progression (p  =  0.001) or @entity4 recurrence (0.0004) in the CT group, but with prolonged follow-up this difference was no longer significant. CONCLUSIONS: Early postoperative CT does not improve OS after @entity6 and HIPEC for @entity5 . However, a transient effect on PFS and PRFS was observed. A subgroup of @entity0 who may benefit more from CT remain to be defined.

title: Early Postoperative Chemotherapy After Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for @entity4 of XXXX : A Multicenter Study.

answer: @entity5


abstract: PURPOSE: The prognosis of @entity4 ( @entity4 ) from @entity2 has been improved with @entity6 ( @entity6 ) and hyperthermic intraperitoneal chemotherapy (HIPEC). However, benefits of postoperative chemotherapy (CT) are unclear. METHODS: This retrospective, multicenter study included 231 @entity0 treated by @entity6 and HIPEC for isolated @entity4 of @entity5 in four expert's centers. Overall survival (OS), progression-free survival (PFS), and peritoneal recurrence-free survival (PRFS) were compared between @entity0 with adjuvant CT (started within 3  months after surgery) and @entity0 with surveillance only. RESULTS: After exclusion of 10 @entity0 for early postoperative @entity3 (4  %), 221 @entity0 were included (CT group: n  =  151; surveillance group: n  =  70). Main postoperative CT regimens (median of 6 cycles) were Folfox (28  %), Folfiri bevacizumab (24.5  %), Folfiri (16  %), and Folfiri cetuximab (12.5  %). The median OS after surgery was 43.3  months with no difference between CT and surveillance groups. In multivariate analysis, a low peritoneal @entity1 index (p  <  0.0001) and a long delay between diagnosis of @entity7 and HIPEC (p  =  0.001) were associated with increased OS. The median PFS and PRFS were 12.4 and 17  months, respectively. At 1  year, more @entity0 were without progression (p  =  0.001) or @entity4 recurrence (0.0004) in the CT group, but with prolonged follow-up this difference was no longer significant. CONCLUSIONS: Early postoperative CT does not improve OS after @entity6 and HIPEC for @entity5 . However, a transient effect on PFS and PRFS was observed. A subgroup of @entity0 who may benefit more from CT remain to be defined.

title: Early Postoperative Chemotherapy After Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for XXXX of @entity5 : A Multicenter Study.

answer: @entity4


abstract: UNASSIGNED: This long-term follow-up analysis evaluated @entity4 ( @entity4 ) and @entity5 ( @entity5 ) in a phase 2 study of the bispecific T-cell engager (BiTE  ) antibody construct blinatumomab in 36 adults with relapsed/refractory B-precursor @entity3 . In the primary analysis, 25 (69%) @entity0 achieved complete remission with full (CR) or partial ( @entity6 ) recovery of peripheral blood counts within the first 2 cycles. Twenty-five @entity0 (69%) had a @entity1 ( @entity1 ) response (< 10(-4) blasts), including 22 CR/ @entity6 responders, two @entity0 with @entity2 , and one @entity0 with normocellular marrow but low peripheral counts. Ten of the 36 @entity0 (28%) were long-term survivors ( @entity4 >=  30 months). Median @entity4 was 13.0 months (median follow-up, 32.6 months). @entity1 response was associated with significantly longer @entity4 (Mantel-Byar P = 0.009). All 10 long-term survivors had an @entity1 response. Median @entity5 was 8.8 months (median follow-up, 28.9 months). A plateau for @entity5 was reached after approximately 18 months. Six of the 10 long-term survivors remained relapse-free, including four who received allogeneic stem cell transplantation (alloSCT) as consolidation for blinatumomab and two who received three additional cycles of blinatumomab instead of alloSCT. Three long-term survivors had neurologic events or @entity7 resulting in temporary blinatumomab discontinuation; all restarted blinatumomab successfully. Long-term survivors had more pronounced T-cell expansion than @entity0 with @entity4 < 30 months.

title: Long-term survival and T-Cell kinetics in adult @entity0 with relapsed/refractory B-precursor XXXX who achieved @entity1 response following treatment with Anti-CD19 BiTE   antibody construct blinatumomab.

answer: @entity3


abstract: UNASSIGNED: This long-term follow-up analysis evaluated @entity4 ( @entity4 ) and @entity5 ( @entity5 ) in a phase 2 study of the bispecific T-cell engager (BiTE  ) antibody construct blinatumomab in 36 adults with relapsed/refractory B-precursor @entity3 . In the primary analysis, 25 (69%) @entity0 achieved complete remission with full (CR) or partial ( @entity6 ) recovery of peripheral blood counts within the first 2 cycles. Twenty-five @entity0 (69%) had a @entity1 ( @entity1 ) response (< 10(-4) blasts), including 22 CR/ @entity6 responders, two @entity0 with @entity2 , and one @entity0 with normocellular marrow but low peripheral counts. Ten of the 36 @entity0 (28%) were long-term survivors ( @entity4 >=  30 months). Median @entity4 was 13.0 months (median follow-up, 32.6 months). @entity1 response was associated with significantly longer @entity4 (Mantel-Byar P = 0.009). All 10 long-term survivors had an @entity1 response. Median @entity5 was 8.8 months (median follow-up, 28.9 months). A plateau for @entity5 was reached after approximately 18 months. Six of the 10 long-term survivors remained relapse-free, including four who received allogeneic stem cell transplantation (alloSCT) as consolidation for blinatumomab and two who received three additional cycles of blinatumomab instead of alloSCT. Three long-term survivors had neurologic events or @entity7 resulting in temporary blinatumomab discontinuation; all restarted blinatumomab successfully. Long-term survivors had more pronounced T-cell expansion than @entity0 with @entity4 < 30 months.

title: Long-term survival and T-Cell kinetics in adult @entity0 with relapsed/refractory B-precursor @entity3 who achieved XXXX response following treatment with Anti-CD19 BiTE   antibody construct blinatumomab.

answer: @entity1


abstract: UNASSIGNED: This long-term follow-up analysis evaluated @entity4 ( @entity4 ) and @entity5 ( @entity5 ) in a phase 2 study of the bispecific T-cell engager (BiTE  ) antibody construct blinatumomab in 36 adults with relapsed/refractory B-precursor @entity3 . In the primary analysis, 25 (69%) @entity0 achieved complete remission with full (CR) or partial ( @entity6 ) recovery of peripheral blood counts within the first 2 cycles. Twenty-five @entity0 (69%) had a @entity1 ( @entity1 ) response (< 10(-4) blasts), including 22 CR/ @entity6 responders, two @entity0 with @entity2 , and one @entity0 with normocellular marrow but low peripheral counts. Ten of the 36 @entity0 (28%) were long-term survivors ( @entity4 >=  30 months). Median @entity4 was 13.0 months (median follow-up, 32.6 months). @entity1 response was associated with significantly longer @entity4 (Mantel-Byar P = 0.009). All 10 long-term survivors had an @entity1 response. Median @entity5 was 8.8 months (median follow-up, 28.9 months). A plateau for @entity5 was reached after approximately 18 months. Six of the 10 long-term survivors remained relapse-free, including four who received allogeneic stem cell transplantation (alloSCT) as consolidation for blinatumomab and two who received three additional cycles of blinatumomab instead of alloSCT. Three long-term survivors had neurologic events or @entity7 resulting in temporary blinatumomab discontinuation; all restarted blinatumomab successfully. Long-term survivors had more pronounced T-cell expansion than @entity0 with @entity4 < 30 months.

title: Long-term survival and T-Cell kinetics in adult XXXX with relapsed/refractory B-precursor @entity3 who achieved @entity1 response following treatment with Anti-CD19 BiTE   antibody construct blinatumomab.

answer: @entity0


abstract: OBJECTIVES: To investigate the association between @entity2 , hearing aid use, and @entity1 . DESIGN: Prospective population-based study. SETTING: Data gathered from the Personnes Ag  es QUID study, a cohort study begun in 1989-90. @entity0 : Individuals aged 65 and older (N = 3,670). MEASUREMENTS: At baseline, @entity2 was determined using a questionnaire assessing self-perceived @entity2 ; 137 subjects reported major @entity2 , 1,139 reported moderate problems (difficulty following the conversation when several @entity0 talk at the same time or in a noisy background), and 2,394 reported no hearing trouble. @entity1 was measured using the @entity3 ( @entity3 ), administered at follow-up visits over 25 years. RESULTS: Self-reported @entity2 was significantly associated with lower baseline @entity3 score (b = -0.69, P < .001) and greater decline during the 25-year follow-up period (b = -0.04, P = .01) independent of age, sex, and education. A difference in the rate of change in @entity3 score over the 25-year follow-up was observed between @entity0 with @entity2 not using hearing aids and controls (b = -0.06, P < .001). In contrast, subjects with @entity2 using a hearing aid had no difference in @entity1 (b = 0.07, P = .08) from controls. CONCLUSION: Self-reported @entity2 is associated with accelerated @entity1 in older adults; hearing aid use attenuates such decline.

title: Self-Reported Hearing Loss, Hearing Aids, and XXXX in Elderly Adults: A 25-Year Study.

answer: @entity1


abstract: BACKGROUND: On the basis of results of previous Japanese trials for @entity5 in @entity3 (ML-DS), the efficacy of risk-oriented therapy was evaluated in the Japanese @entity2 Study Group AML-D05 study. PROCEDURE: All @entity0 received induction chemotherapy that consisted of @entity7 , intermediate-dose @entity4 , and @entity6 . @entity0 who achieved complete remission (CR) after initial induction therapy were stratified to the standard risk (SR) group and received four courses of reduced-dose intensification therapy. @entity0 who did not achieve CR were stratified to the high risk (HR) group and received intensified therapy that consisted of continuous or high-dose @entity4 . RESULTS: A total of 72 @entity0 were eligible and evaluated. One @entity0 died of @entity1 during initial induction therapy. Sixty-nine @entity0 were stratified to SR and two @entity0 to HR. No therapy-related deaths were observed during intensification therapy. The 3-year event-free and overall survival rates were 83.3%      4.4% and 87.5%      3.9 %, respectively. Age at diagnosis less than 2 years was a significant favorable prognostic factor for risk of relapse (P  =  0.009). CONCLUSIONS: The attempt of risk-oriented prospective study for ML-DS was unsuccessful, but despite the dose reduction of chemotherapeutic agents, the overall outcome was good, and further dose reduction might be possible for specific subgroups.

title: Preserved High Probability of Overall Survival with Significant Reduction of Chemotherapy for XXXX in Down Syndrome: A Nationwide Prospective Study in Japan.

answer: @entity5


abstract: UNASSIGNED: @entity1 ( @entity1 ) and @entity2 ( @entity2 ) are associated with organ damage. In the present study, we examined the correlation between the magnitude of white-coat effect (WCE) or reverse WCE (RWCE) and 24-h pulse pressure (PP), an indicator of target organ damage and arterial stiffness, in @entity0 and young adults. We also examined the relationship of WCE or RWCE and blood pressure (BP) variability, another predictor of clinical outcomes. One hundred and ninety-eight subjects were studied. According to the office BP and ambulatory BP, they were divided into normotension, @entity2 , @entity1 , and @entity1 . The magnitude of WCE or RWCE, along with male gender and 24-h systolic BP, was the determinant of 24-h PP. In subjects with 24-h PP  >=   61  mmHg, the magnitude of WCE or RWCE, age, male ratio, height, weight, BMI, the percentage of secondary @entity1 , that of @entity1 , office systolic BP, and 24-h systolic BP were significantly greater. There was a progressive increase in 24-h PP from normotension, @entity2 , @entity1 , to @entity1 . BP variability in subjects with @entity1 was numerically highest in both systolic and diastolic. Diastolic BP variability of @entity2 , @entity1 , and @entity1 was significantly higher than that of normotension. Finally, the magnitude of WCE or RWCE in systolic showed a significant correlation with systolic BP variability. In conclusion, the magnitude of WCE or RWCE correlates with 24-h PP and systolic BP variability, which may suggest increased arterial stiffness in @entity2 and @entity1 .

title: White-Coat and Reverse White-Coat Effects Correlate with 24-h Pulse Pressure and Systolic Blood Pressure Variability in XXXX and Young Adults.

answer: @entity0


abstract: Potentially lethal damage repair (PLDR) in @entity1 cells was investigated by delayed plating experiments with three malignant @entity2 cell lines (breast, colon and @entity3 ) and two normal diploid lines (lung fibroblasts) in exponential and plateau phases. All cell lines demonstrated PLDR which was considerably higher for all the cell lines in plateau phase compared to log phase. At survival levels of 0.01, the two fibroblast lines had recovery ratios of 3.8 and 4.0 for 6 h delayed plating in plateau phase. The malignant lines showed recovery ratios of 5.7 ( @entity3 ), 3.2 ( @entity0 ) and 2.4 ( @entity4 ). The data were fitted to the linear quadratic equation and in addition, a repair factor was developed to compare survival for immediate and delayed plating: S(D) = exp[-gamma (alpha D + beta D2)] where gamma = 1 for immediate plating. Previously published data on @entity1 @entity2 and normal lines were also fitted to this equation. In all instances the three parameter equation (alpha, beta, gamma) allowed a good fit of the survival data for immediate and delayed plating. By using the same alpha, beta for the zero hour and 6 h survival curves, the gamma factor allows a much more useful method of comparing PLDR among different cell lines. The gamma factor for the two lung fibroblast lines were 0.70 and 0.71 while skin fibroblasts also had a 0.71 factor. The six malignant lines ranged from 0.62 to 0.93 with all but the @entity3 line having a higher factor (and therefore decreased PLDR capacity) than the normal lines. No correlation between PLDR and in vitro radiosensitivity or clinical radiosensitivity of the @entity2 type was found.

title: Potentially lethal damage repair in XXXX cells.

answer: @entity1


abstract: The effects of adrenergic activation on @entity1 and the @entity1 induced endocrine changes were tested in @entity0 . Alpha 2 adrenoceptor blockers were used for enhancing activation of the adrenergic system, and changes in @entity1 were tested in resident-intruder contests. Three experiments were conducted. In experiment 1, saline injected @entity0 responded to the presence of an opponent by @entity1 and the increase in plasma ACTH and @entity3 . Intraperitoneal administration of 1 mg/kg @entity8 (an alpha 2 adrenoceptor antagonist) produced a several fold increase in clinch fighting and mutual upright scores, and also further enhanced the plasma ACTH and @entity3 response. In experiment 2, the effect of three doses (0.5, 1 and 2 mg/kg) of three different alpha 2 adrenoceptor blockers @entity8 , @entity7 and @entity5 were tested. All the substances increased @entity1 at 0.5 and 1 mg/kg; at 2 mg/kg the effect of @entity7 and @entity5 disappeared, while with @entity8 an additional increase was obtained. In @entity5 treated animals the enhancement of @entity1 was reduced already at 1 mg/kg. In experiment 3, @entity6 , a potent inhibitor of the @entity4 -induced ACTH release completely abolished the effects of the alpha 2 adrenoceptor antagonist @entity8 : the intensity of agonistic interactions, as well as ACTH and @entity3 plasma concentrations, returned to control levels. The possible role of @entity2 and the stress hormones in the activation of @entity1 is discussed.

title: Alpha 2-adrenoceptor blockade, pituitary-adrenal hormones, and agonistic interactions in XXXX .

answer: @entity0


abstract: In 1992 @entity0 aged 65 years and over represented 11.9% ( @entity0 ) and 17.2% ( @entity0 ) of the Swiss population, and in 2000 the average 65-year-old @entity0 or @entity0 can expect to live about 12 more years. Old age is characterized by multimorbidity, an accumulation of chronic conditions and diseases, and by social isolation. Multimorbidity and isolation (living alone) are the major risk factors for @entity7 . 30-60% of all @entity0 aged 65 years and over show one or more subnormal nutritional parameters. The unspecific and oligosymptomatic clinical picture of @entity7 in the elderly often hinders an early diagnosis, and @entity7 is often misdiagnosed as "wasting away syndrome" of the old. Thus, the nutritional assessment of the elderly should become a routine diagnostic procedure. Detection of @entity7 involves assessment of nutritional parameters including history (eating habits, appetite), anthropometric measurements (weight, height, body mass index, triceps skinfold, midarm circumference), serum proteins (albumin, @entity2 , prealbumin, cholinesterase, @entity5 binding protein), vitamins (B12, folic acid, @entity8 ), minerals and trace elements ( @entity3 , @entity6 , @entity4 , @entity1 ), immunologic skin tests and lymphocyte count. Depending on the history and the clinical symptoms, a selected number of these nutritional parameters are assessed. When assessing the nutritional status of the elderly it is important to define the etiologic factors involved. Thus, treatment of underlying causes and refeeding can be streamlined, so that maximum benefit can be obtained for the quality of life of the elderly.

title: [Special aspects of XXXX in geriatrics].

answer: @entity7


abstract: Over the past few years, the central role of cytokines in the amplification of the immune response has been reported and several studies have examined the relationship between the plasma level of individual lymphokines during renal allograft rejection. The aim of the present investigation was to study simultaneously @entity3 , @entity4 , @entity5 , @entity1 , @entity2 , and soluble @entity6 . Analysis of results has allowed both the prognostic value and any possible interrelationships between the measured cytokines to be determined. We studied 16 renal transplant recipients for the first 14 days after transplantation. Seven @entity0 showed clinical evidence of acute allograft rejection and 5 showed excellent stable graft function with no signs of rejection. Primary nonfunction was seen in 4 @entity0 . The plasma levels of each cytokine were measured by commercially available ELISA and immunoradiometric assay kits. As reported in previous studies, plasma @entity3 levels, whenever found at detectable levels, were predictive of impending graft rejection. Serial monitoring of @entity5 and @entity1 was more reliable for the differential diagnosis of rejection, particularly toward the end of the first week after transplantation. @entity4 , @entity2 , and soluble @entity6 were not diagnostic or predictive of rejection, due to the occurrence of significantly high levels in transplant @entity0 who showed no evidence of clinical rejection. While the value of cytokine monitoring has been shown in this study, it should be remembered that infection, although not seen in these studies, may have a profound affect on the results obtained.

title: The value of posttransplant monitoring of interleukin (IL)-2, @entity4 , @entity5 , @entity1 , XXXX , and soluble @entity6 in the plasma of renal allograft recipients.

answer: @entity2


abstract: Over the past few years, the central role of cytokines in the amplification of the immune response has been reported and several studies have examined the relationship between the plasma level of individual lymphokines during renal allograft rejection. The aim of the present investigation was to study simultaneously @entity3 , @entity4 , @entity5 , @entity1 , @entity2 , and soluble @entity6 . Analysis of results has allowed both the prognostic value and any possible interrelationships between the measured cytokines to be determined. We studied 16 renal transplant recipients for the first 14 days after transplantation. Seven @entity0 showed clinical evidence of acute allograft rejection and 5 showed excellent stable graft function with no signs of rejection. Primary nonfunction was seen in 4 @entity0 . The plasma levels of each cytokine were measured by commercially available ELISA and immunoradiometric assay kits. As reported in previous studies, plasma @entity3 levels, whenever found at detectable levels, were predictive of impending graft rejection. Serial monitoring of @entity5 and @entity1 was more reliable for the differential diagnosis of rejection, particularly toward the end of the first week after transplantation. @entity4 , @entity2 , and soluble @entity6 were not diagnostic or predictive of rejection, due to the occurrence of significantly high levels in transplant @entity0 who showed no evidence of clinical rejection. While the value of cytokine monitoring has been shown in this study, it should be remembered that infection, although not seen in these studies, may have a profound affect on the results obtained.

title: The value of posttransplant monitoring of interleukin (IL)-2, @entity4 , @entity5 , @entity1 , @entity2 , and soluble XXXX in the plasma of renal allograft recipients.

answer: @entity6


abstract: Over the past few years, the central role of cytokines in the amplification of the immune response has been reported and several studies have examined the relationship between the plasma level of individual lymphokines during renal allograft rejection. The aim of the present investigation was to study simultaneously @entity3 , @entity4 , @entity5 , @entity1 , @entity2 , and soluble @entity6 . Analysis of results has allowed both the prognostic value and any possible interrelationships between the measured cytokines to be determined. We studied 16 renal transplant recipients for the first 14 days after transplantation. Seven @entity0 showed clinical evidence of acute allograft rejection and 5 showed excellent stable graft function with no signs of rejection. Primary nonfunction was seen in 4 @entity0 . The plasma levels of each cytokine were measured by commercially available ELISA and immunoradiometric assay kits. As reported in previous studies, plasma @entity3 levels, whenever found at detectable levels, were predictive of impending graft rejection. Serial monitoring of @entity5 and @entity1 was more reliable for the differential diagnosis of rejection, particularly toward the end of the first week after transplantation. @entity4 , @entity2 , and soluble @entity6 were not diagnostic or predictive of rejection, due to the occurrence of significantly high levels in transplant @entity0 who showed no evidence of clinical rejection. While the value of cytokine monitoring has been shown in this study, it should be remembered that infection, although not seen in these studies, may have a profound affect on the results obtained.

title: The value of posttransplant monitoring of interleukin (IL)-2, @entity4 , XXXX , @entity1 , @entity2 , and soluble @entity6 in the plasma of renal allograft recipients.

answer: @entity5


abstract: Over the past few years, the central role of cytokines in the amplification of the immune response has been reported and several studies have examined the relationship between the plasma level of individual lymphokines during renal allograft rejection. The aim of the present investigation was to study simultaneously @entity3 , @entity4 , @entity5 , @entity1 , @entity2 , and soluble @entity6 . Analysis of results has allowed both the prognostic value and any possible interrelationships between the measured cytokines to be determined. We studied 16 renal transplant recipients for the first 14 days after transplantation. Seven @entity0 showed clinical evidence of acute allograft rejection and 5 showed excellent stable graft function with no signs of rejection. Primary nonfunction was seen in 4 @entity0 . The plasma levels of each cytokine were measured by commercially available ELISA and immunoradiometric assay kits. As reported in previous studies, plasma @entity3 levels, whenever found at detectable levels, were predictive of impending graft rejection. Serial monitoring of @entity5 and @entity1 was more reliable for the differential diagnosis of rejection, particularly toward the end of the first week after transplantation. @entity4 , @entity2 , and soluble @entity6 were not diagnostic or predictive of rejection, due to the occurrence of significantly high levels in transplant @entity0 who showed no evidence of clinical rejection. While the value of cytokine monitoring has been shown in this study, it should be remembered that infection, although not seen in these studies, may have a profound affect on the results obtained.

title: The value of posttransplant monitoring of interleukin (IL)-2, XXXX , @entity5 , @entity1 , @entity2 , and soluble @entity6 in the plasma of renal allograft recipients.

answer: @entity4


abstract: Over the past few years, the central role of cytokines in the amplification of the immune response has been reported and several studies have examined the relationship between the plasma level of individual lymphokines during renal allograft rejection. The aim of the present investigation was to study simultaneously @entity3 , @entity4 , @entity5 , @entity1 , @entity2 , and soluble @entity6 . Analysis of results has allowed both the prognostic value and any possible interrelationships between the measured cytokines to be determined. We studied 16 renal transplant recipients for the first 14 days after transplantation. Seven @entity0 showed clinical evidence of acute allograft rejection and 5 showed excellent stable graft function with no signs of rejection. Primary nonfunction was seen in 4 @entity0 . The plasma levels of each cytokine were measured by commercially available ELISA and immunoradiometric assay kits. As reported in previous studies, plasma @entity3 levels, whenever found at detectable levels, were predictive of impending graft rejection. Serial monitoring of @entity5 and @entity1 was more reliable for the differential diagnosis of rejection, particularly toward the end of the first week after transplantation. @entity4 , @entity2 , and soluble @entity6 were not diagnostic or predictive of rejection, due to the occurrence of significantly high levels in transplant @entity0 who showed no evidence of clinical rejection. While the value of cytokine monitoring has been shown in this study, it should be remembered that infection, although not seen in these studies, may have a profound affect on the results obtained.

title: The value of posttransplant monitoring of interleukin (IL)-2, @entity4 , @entity5 , XXXX , @entity2 , and soluble @entity6 in the plasma of renal allograft recipients.

answer: @entity1


abstract: 1. The trehalase found in an extract prepared from a @entity0 that cannot ferment @entity3 was studied and characterized. The enzyme is highly specific for @entity3 with K(m) 1.02x10(-2)m, and an optimum pH of 6.9. 2. It is inhibited by @entity1 and by @entity4 , and does not facilitate any significant transglucosylations. 3. pK values 7.7 and 5.8 were detected for the groups associated with binding of the non-ionized substrate to the enzyme. 4. The trehalase was found to be highly labile and was inhibited by @entity2 -binding reagents. 5. The possible role of this enzyme in the @entity3 -dissimilation patterns in the @entity0 cell was evaluated.

title: Intracellular trehalase of a hybrid XXXX .

answer: @entity0


abstract: The two major urinary metabolites of @entity1 are @entity3 (BE) and @entity4 (EME). The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas chromatographic screening. To ascertain the merits of screening BE versus EME for identifying @entity1 use, 380 consecutive urine specimens presented to the Office of the Chief Medical Examiner-State of Maryland were tested for BE by EMIT (cutoff 0.3 mg/L) and for EME by gas chromatography- @entity0 - @entity2 detection (cutoff 0.05 mg/L). Each presumptive positive was confirmed by gas chromatography-mass spectrometry. One hundred four specimens tested positive for BE or EME. Ninety three specimens were positive for both BE and EME, seven were positive for BE (cutoff 0.05 mg/L) only and four were positive for EME only. BE concentrations ranged from 0.08-386 mg/L while EME concentrations ranged from 0.06-72 mg/L. The BE concentration was greater than or equal to the EME concentration in 73% of the cases. Using BE as a sole screen, 96% of the cases of @entity1 use were identified while EME screening identified 93% of the cases.

title: @entity3 and XXXX concentrations in urine specimens.

answer: @entity4


abstract: The two major urinary metabolites of @entity1 are @entity3 (BE) and @entity4 (EME). The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas chromatographic screening. To ascertain the merits of screening BE versus EME for identifying @entity1 use, 380 consecutive urine specimens presented to the Office of the Chief Medical Examiner-State of Maryland were tested for BE by EMIT (cutoff 0.3 mg/L) and for EME by gas chromatography- @entity0 - @entity2 detection (cutoff 0.05 mg/L). Each presumptive positive was confirmed by gas chromatography-mass spectrometry. One hundred four specimens tested positive for BE or EME. Ninety three specimens were positive for both BE and EME, seven were positive for BE (cutoff 0.05 mg/L) only and four were positive for EME only. BE concentrations ranged from 0.08-386 mg/L while EME concentrations ranged from 0.06-72 mg/L. The BE concentration was greater than or equal to the EME concentration in 73% of the cases. Using BE as a sole screen, 96% of the cases of @entity1 use were identified while EME screening identified 93% of the cases.

title: XXXX and @entity4 concentrations in urine specimens.

answer: @entity3


abstract: The clinical and pathological features of 35 cases with @entity5 collected in the United Kingdom @entity0 Society Brain Bank (UKPDSBB) between 1985 and 1992 have been analysed. The median age of onset was 55 (range 33.3-75.8) years and median survival was 7.3 (range 2.1-11.5) years. @entity2 , usually asymmetric, occurred in all, and @entity6 in all but one case. Cerebellar signs were noted in 34% and pyramidal features in 54% of the cases. Glial cytoplasmic inclusions were found in all cases with adequate fixation. Lewy bodies were detected in three cases. The substantia nigra was (usually severely) depleted of cells in all cases. With two exceptions the putamen was @entity4 ; the caudate and pallidum were less commonly and less severely affected. Overall nigrostriatal cell loss correlated with severity of disease at the time of @entity1 . The latest, but not the best, recorded levodopa response tended to be inversely related to the degree of @entity3 . The olivopontocerebellar system was involved in 88% of the cases, the cerebellar vermis usually being more severely affected than the hemispheres. The presence of associated cerebellar pathology was, however, unrelated to the presence of cerebellar signs in life.

title: Clinicopathological study of 35 cases of XXXX .

answer: @entity5


abstract: Two cases of peripartum @entity3 , a rare type of @entity4 , are reported. A 36-year-old @entity0 developed @entity5 1 month after delivering her third @entity0 . Cardiac catheterization revealed diffuse hypokinesis of the left ventricle and an ejection fraction of 28%. The second study, 20 months later, demonstrated an ejection fraction of 46%. Endomyocardial biopsy showed mild @entity1 . A 42-year-old @entity0 developed @entity6 during pregnancy. She delivered her second @entity0 at 38 weeks of gestation. Two weeks later, she developed @entity5 . Cardiac catheterization demonstrated diffuse hypokinesis of left ventricle with an ejection fraction of 40%. Endomyocardial biopsy revealed dense @entity2 . Follow-up angiography performed 8 months later showed similar findings with an ejection fraction of 34%. These two cases suggest the importance of evaluation of endomyocardial biopsy to determine the degree of @entity2 that may reflect the prognosis for @entity0 with peripartum @entity3 confirmed by measurements of ejection fraction.

title: [Two cases of peripartum XXXX ].

answer: @entity3


abstract: PURPOSE: The aim of this study was to present a 20-year experience with a single method of passive distal perfusion during descending thoracic aortic @entity3 resection. METHODS: Aortic repair with a Dacron graft interposition was performed for 366 consecutive @entity3 located between the left subclavian artery and the crux of the diaphragm. The extent of aorta resected in 335 @entity0 (91.5%) represented one third or less of the aortic length. @entity6 mm Gott shunt was cannulated proximally into the ascending aorta (235 cases), the aortic arch (60 cases), the descending aorta (68 cases), or the left ventricle (3 cases) and inserted distally into the descending aorta (232 cases), the femoral artery (127 cases), or the abdominal aorta (7 cases). Shunt flows were recorded in 91 cases and varied from 1100 ml to 4900 ml/min, (mean 2526 ml/min). Distal pressure during shunting was measured in 62 @entity0 . It varied from 15 to 120 mm Hg (mean 64.5 mm Hg). The aortic cross-clamp time varied from 8 to 124 minutes (mean 30 minutes). RESULTS: The hospital death rate was 12% overall and 9.9% (35/351) if @entity5 are excluded. Among 359 operating room survivors, neither immediate nor delayed ischemic @entity4 occurred. Transient @entity1 occurred in nine @entity0 (2.4%) and @entity2 in one (0.2%). Five deaths (1.3%) were shunt related. CONCLUSION: Distal perfusion with the 9 mm Gott shunt has proven to be an effective method to preserve spinal cord function. The limited extent of aorta resected and the brief aortic cross-clamp time may also be interactive factors of protection.

title: XXXX of the descending thoracic aorta: three hundred sixty-six consecutive cases resected without paraplegia.

answer: @entity3


abstract: PURPOSE: The purpose of this study was to determine the relationship between admission and postoperative platelet count (PC) and mortality and morbidity rates after emergency surgery for @entity10 ( @entity5 ). METHODS: We performed a case record review of 65 consecutive @entity0 admitted with @entity10 . RESULTS: Five @entity0 did not undergo operation because of poor clinical condition, 12 @entity0 died at operation, 13 @entity0 died after operation, and 35 @entity0 survived (operative mortality rate of 58%). Fifteen @entity0 had an admission PC of less than 150 x 10(9)/L, of whom 14 (93%) died; 27 @entity0 had an admission PC of 150 to 250 x 10(9)/L, of whom 8 (30%) died; and 18 @entity0 had an admission PC of greater than 250 x 10(9)/L of whom 3 (17%) died. At the end of operation 29 @entity0 had a PC of less than 100 x 10(9)/L, of whom 13 (45%) died, 20 (69%) had development of @entity1 ( @entity1 ), and 6 (21%) required relaparotomy for @entity3 complications. By contrast, all 19 @entity0 having a PC of 100 x 10(9)/L or greater at the end of the operation survived, three (16%) had development of @entity1 , and none required further surgery for @entity3 . There was a significant inverse correlation between PC at the end of the operation and the number of postoperative days spent on a ventilator, in the intensive therapy unit, and in hospital. After operation, 15 @entity0 had development of @entity7 (PC > 400 x 10(9)/L), of whom 10 had development of @entity8 and 8 had development of @entity9 . There were no deep @entity8 or @entity9 in @entity0 who did not have development of a postoperative @entity7 . CONCLUSIONS: There is a direct correlation between PC on admission to the hospital and @entity2 after emergency repair of @entity10 . @entity4 at the end of the operation is associated with a high risk of morbidity from continuing @entity3 or @entity1 . The development of postoperative @entity7 is associated with a high risk of @entity6 complications. PC provides a simple marker of outcome in @entity0 diagnosed with and undergoing operation for @entity10 .

title: Platelet count and the outcome of operation for XXXX .

answer: @entity10


abstract: We have examined the factors influencing prognosis in over 4000 @entity0 with @entity2 ( @entity2 ) aged 1-14 who have been treated on consecutive MRC UKALL trials from 1972 to 1990. During this time the results of treatment have improved steadily but are consistently superior in @entity0 when compared with @entity0 ; the 5-year event-free survival in @entity0 improving from 51% to 71% and in @entity0 from 31% to 57%. These results were independent of age and presenting leucocyte count. @entity0 not only had a testicular relapse rate of 10% but an excess of @entity1 , particularly evident after 2 years from diagnosis. Other prognostic factors included @entity4 and the morphology of leukaemic blast cells; immunophenotype of the @entity3 , however, had no independent significance after allowance for age, sex and leucocyte count. The influence of sex on prognosis was reaffirmed when we examined various methods of identifying @entity0 at highest risk of treatment failure for whom alternative therapy such as bone marrow transplantation might be justified. In MRC UKALL X @entity0 had been deemed 'high risk' on the basis of leucocyte count alone, but with further follow-up it has become apparent that @entity0 with an initial leucocyte count of > 100 x 10(9)/l have a similar prognosis to @entity0 with a lower count. We therefore derived a risk score based on sex, age and count which has given better discrimination between standard risk (66% 5-year survival) and poor risk (39%) survival than other methods. This group of worse-risk @entity0 includes 16% of @entity0 but only 3% of all @entity0 . Gender remains an important prognostic factor in UKALL trials and there are very few @entity0 who are at highest risk of treatment failure. The reasons for this remain unclear, but the pattern of relapses suggests that @entity0 more often get inadequate systemic therapy. We postulate that the reasons for treatment failure may relate to sensitivity to continuing (maintenance) chemotherapy.

title: Gender and treatment outcome in XXXX : report from the MRC UKALL trials.

answer: @entity2


abstract: The term @entity9 encompasses @entity6 . Fissuring of an @entity5 coronary artery plaque with superimposed platelet deposition, with or without additional @entity4 formation, is invariably responsible for a prolonged episode of @entity7 at rest, increasing frequency of @entity7 at rest, or with minimal exertion of less than 4 weeks in duration and early postinfarction @entity7 . Plaque progression, rather than plaque fissuring, is the most likely mechanism for progressive reduction in walking distance due to @entity7 in @entity0 who previously have stable @entity7 . @entity10 is responsible for @entity12 , but its exact role in other forms of @entity9 is unknown. The mainstay of treatment of @entity9 (prolonged episode of @entity7 at rest and recent onset @entity7 at rest, or with minimal exertion with a crescendo pattern) is @entity1 , heparin, or both. Both @entity1 and intravenous (i.v.) heparin or their combination reduce early mortality and the incidence of @entity2 in @entity0 hospitalized with @entity9 . However, these agents do not promptly relieve @entity3 . There are no placebo-controlled studies evaluating the usefulness of @entity11 in @entity9 . In open-label studies, continuous therapy with i.v. @entity8 (NTG) for 24 hours or longer has been shown to relieve @entity3 in @entity0 with @entity9 refractory to therapy with other antianginal agents, including long-acting nitrates. Recurrence of @entity3 in @entity0 receiving i.v. NTG is a common problem and probably represents development of pharmacologic tolerance, but this can be overridden by dose escalation; protracted tolerance during short-term use of i.v. NTG is usually not a problem.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Nitrates for XXXX .

answer: @entity9


abstract: We found that @entity0 monocytes differentiate into macrophages (Mp) by @entity1 and @entity7 . The Mp induced by @entity1 and @entity7 are different in their morphology, @entity3 expression and functions. In the course of that study, we found that @entity4 modulate the differentiation of monocytes induced by @entity1 and @entity7 . @entity4 alone did not induce the proliferation and differentiation of monocytes. @entity4 , however, inhibited the proliferative response of monocytes to @entity1 . When monocytes were incubated with @entity1 and @entity4 simultaneously, the cells recovered were non-adherent, non-phagocytic, and did not form rosette with EA. The cells were also negative in nonspecific esterase and showed an appearance of dendritic cells (DC). The DC-like cells expressed @entity5 , DR, DQ and @entity2 , but not @entity6 , @entity8 and 710F. The cells showed strong APC activity in alogeneic and autologous mixed lymphocyte reaction (MLR). When monocytes were incubated with @entity7 and @entity4 , TRAP positive multinucleated giant cells appeared. Taken together, these results suggest that @entity4 is a principal factor that control the differential development of @entity0 monocytes into DC and multinucleated giant cells.

title: [Differentiation and function of XXXX monocytes].

answer: @entity0


abstract: INTRODUCTION: Embolization is a well-established technique that facilitates the subsequent surgical @entity1 such as @entity5 . However, there is risk of a neurological accident during angiography and @entity1 embolization from the internal carotid artery. Direct intratumoral embolization may help prevent these potential side effects. METHOD: A group of 7 @entity0 with @entity5 vascularized through the branches of the internal carotid artery underwent direct tumoral embolization under general anesthesia. An injection made slowly with an intranasal or lateral percutaneous route with either a mixture of @entity3 , lipiodal, and @entity4 powder. Continuous radiographic control was used. RESULTS: This technique induced a marked devascularization and @entity2 of the @entity1 . The technique provided useful perioperative visualization of the @entity1 . No neurologic sequelae were encountered. CONCLUSION: Direct intratumoral embolization deserves further consideration. This might be especially important in @entity1 with extracranial extension, cavernous sinus involvement, or those with small or multiple recurrences.

title: Direct intratumoral embolization of XXXX .

answer: @entity5


abstract: A series of @entity2 from an Asian population in Singapore were analyzed for mutations in the @entity1 suppressor gene @entity3 . Based on single-strand conformation polymorphism (PCR-SSCP) analysis and direct DNA sequencing, 15 of 38 @entity1 (39%) were found to contain mutations in exons 5-8 of the @entity3 gene. The point mutations were predominantly base transitions. Among the 10 transitions, 5 were at CpG dinucleotide sites. One-third (5/15) of the mutations were found at previously identified hotspot codons 175, 248 and 282. In one case, an insertion of a 6-base pair sequence was found. @entity3 mutations did not correlate with @entity1 histological grade, @entity1 , or @entity0 . However, @entity1 at the distal site showed a higher proportion of mutations than the proximal site. Further, no mutation was found in the normal mucosa adjacent to @entity1 site, suggesting that no germ-line mutations were present. The results were compared with those from other studies and are discussed in connection to possible etiological factors that are specific to the local population.

title: Characterization of XXXX gene mutations in @entity2 from an Asian population.

answer: @entity3


abstract: A series of @entity2 from an Asian population in Singapore were analyzed for mutations in the @entity1 suppressor gene @entity3 . Based on single-strand conformation polymorphism (PCR-SSCP) analysis and direct DNA sequencing, 15 of 38 @entity1 (39%) were found to contain mutations in exons 5-8 of the @entity3 gene. The point mutations were predominantly base transitions. Among the 10 transitions, 5 were at CpG dinucleotide sites. One-third (5/15) of the mutations were found at previously identified hotspot codons 175, 248 and 282. In one case, an insertion of a 6-base pair sequence was found. @entity3 mutations did not correlate with @entity1 histological grade, @entity1 , or @entity0 . However, @entity1 at the distal site showed a higher proportion of mutations than the proximal site. Further, no mutation was found in the normal mucosa adjacent to @entity1 site, suggesting that no germ-line mutations were present. The results were compared with those from other studies and are discussed in connection to possible etiological factors that are specific to the local population.

title: Characterization of @entity3 gene mutations in XXXX from an Asian population.

answer: @entity2


abstract: To determine the indications of body position, continuous positive airway pressure and independent lung ventilation in @entity2 , we turned 10 @entity0 with overwhelming @entity2 from supine to lateral position. All @entity0 were breathing spontaneously with a mask, then associated with continuous airway pressure (10 cm @entity3 PEEP) in five cases. During these spontaneous ventilation methods, hemodynamic parameters did not change, but arterial blood @entity1 tension increased and intra-pulmonary shunting decreased significantly. Final recovery was obtained in 7 cases. In the 3 others, mechanical ventilation was needed because spontaneous breathing methods were ineffective in improving blood gases. Lateral position and conventional ventilation with positive airway pressure were also ineffective. Only independent ventilation enhanced arterial blood @entity1 tension. But only one @entity0 survived. We conclude that spontaneous breathing methods are able to provide successful treatment in most of @entity0 with @entity2 . In other @entity0 , only independent lung ventilation is effective.

title: [Management of unilateral or asymmetrical XXXX (author's transl)].

answer: @entity2


abstract: The aim of this article is to consider how a large quantity of @entity2 (K+) can be excreted without the development of @entity5 . The hypothesis will focus on interactions between K+ and @entity4 - primarily within the kidneys. It is speculated that the absorption of K+ from the gastrointestinal tract is accompanied by an initial addition of @entity4 - to the body; this in turn could, via intrarenal events, promote the delivery of @entity4 - to the cortical collecting duct (CCD), where interactions may permit the development of a very high rate of excretion of K+. To test one portion of this hypothesis, studies were performed in @entity1 because they normally consume approximately 10-fold more K+ per kilogram body weight than do @entity0 . In the absence of a significant degree of anabolism, there is only a limited potential to shift K+ acutely into cells. Hence, an extremely large capacity to excrete K+ is required to avoid a severe degree of @entity5 . The excretion of K+ depends primarily on the ability to have a sustained rise in the (K) in each liter of luminal fluid exiting the CCD to very high levels and to have a large number of liters of fluid exit the terminal CCD while antidiuretic hormone is acting. A reasonable approximation of this CCD flow rate can be obtained by examining the osmole excretion rate when @entity6 acts. Because these @entity1 excreted 1,650 mosmol (2 L x 827 mosm/kg @entity3 ) per day, a minimum estimate for volume delivery out of the CCD is 5 to 6 L/day.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX excretion: a story that is easy to digest.

answer: @entity2


abstract: The nfe genes located on the large plasmid pRmeGR4b are involved in the nodulation efficiency and competitiveness of @entity4 GR4 on alfalfa roots. One hundred twenty-eight base-pairs downstream of nfe2 gene we found an open reading frame designated ORFC, 970 bp long and potentially coding for a 320 @entity0 long protein. The @entity0 sequence of the putatively encoded ORFC product shows similarity with @entity3 cyclodeaminase (OCD) of @entity2 an unusual enzyme that converts @entity3 into @entity1 . The gene product of ORFC was identified as a 37-kDa protein by in vitro-coupled transcription-translation and in vivo by the T7 RNA polymerase/promoter system. DNA hybridization studies showed that strain GR4 carries a single copy of the ocd-like gene. No homologous sequences to GR4 ORFC DNA were found in other @entity4 strains or Rhizobium spp. assayed. Furthermore, a GR4 derivative mutant obtained by plasmid disruption of ORFC showed an impaired nodulation efficiency as compared to that of the wild-type strain GR4. Thus, the former locus should be considered a novel nfe gene. We propose to rename the nfe genes, nfe1, 2 and ORFC as nfeA, B, and D, respectively.

title: Identification of a novel XXXX nodulation efficiency nfe gene homolog of @entity2 @entity3 cyclodeaminase.

answer: @entity4


abstract: The nfe genes located on the large plasmid pRmeGR4b are involved in the nodulation efficiency and competitiveness of @entity4 GR4 on alfalfa roots. One hundred twenty-eight base-pairs downstream of nfe2 gene we found an open reading frame designated ORFC, 970 bp long and potentially coding for a 320 @entity0 long protein. The @entity0 sequence of the putatively encoded ORFC product shows similarity with @entity3 cyclodeaminase (OCD) of @entity2 an unusual enzyme that converts @entity3 into @entity1 . The gene product of ORFC was identified as a 37-kDa protein by in vitro-coupled transcription-translation and in vivo by the T7 RNA polymerase/promoter system. DNA hybridization studies showed that strain GR4 carries a single copy of the ocd-like gene. No homologous sequences to GR4 ORFC DNA were found in other @entity4 strains or Rhizobium spp. assayed. Furthermore, a GR4 derivative mutant obtained by plasmid disruption of ORFC showed an impaired nodulation efficiency as compared to that of the wild-type strain GR4. Thus, the former locus should be considered a novel nfe gene. We propose to rename the nfe genes, nfe1, 2 and ORFC as nfeA, B, and D, respectively.

title: Identification of a novel @entity4 nodulation efficiency nfe gene homolog of XXXX @entity3 cyclodeaminase.

answer: @entity2


abstract: The nfe genes located on the large plasmid pRmeGR4b are involved in the nodulation efficiency and competitiveness of @entity4 GR4 on alfalfa roots. One hundred twenty-eight base-pairs downstream of nfe2 gene we found an open reading frame designated ORFC, 970 bp long and potentially coding for a 320 @entity0 long protein. The @entity0 sequence of the putatively encoded ORFC product shows similarity with @entity3 cyclodeaminase (OCD) of @entity2 an unusual enzyme that converts @entity3 into @entity1 . The gene product of ORFC was identified as a 37-kDa protein by in vitro-coupled transcription-translation and in vivo by the T7 RNA polymerase/promoter system. DNA hybridization studies showed that strain GR4 carries a single copy of the ocd-like gene. No homologous sequences to GR4 ORFC DNA were found in other @entity4 strains or Rhizobium spp. assayed. Furthermore, a GR4 derivative mutant obtained by plasmid disruption of ORFC showed an impaired nodulation efficiency as compared to that of the wild-type strain GR4. Thus, the former locus should be considered a novel nfe gene. We propose to rename the nfe genes, nfe1, 2 and ORFC as nfeA, B, and D, respectively.

title: Identification of a novel @entity4 nodulation efficiency nfe gene homolog of @entity2 XXXX cyclodeaminase.

answer: @entity3


abstract: A series of 55 @entity0 treated with posterior Cotrel-Dubousset instrumentation and osteosynthesis for unstable thoracolumbar spine @entity2 were reviewed. Follow-up averaged 48.3 months. The @entity2 were all unstable, with 27 classified as @entity2 ( @entity2 ) and 28 classified as flexion compression injuries or unstable @entity2 (FC/B). The study population was composed of 29 @entity0 and 26 @entity0 with an average age of 31 (range 20-45) years. Mechanisms of injuries included 35 motor vehicle accidents, 19 falls, and one blunt @entity1 . No case worsened as a result of surgery, and 31% of the cases improved an average of 0.5 Frankel grade (range 0-2). Sixty percent of @entity0 were braced with a custom molded thoracolumbosacral orthosis (TLSO) fitted after surgical stabilization. Minor complications occurred in 45% of the cases ( @entity4 most common). There was a singular deep wound @entity3 and another iliac crest donor site @entity3 . There were no instrument failures or @entity5 . Radiographic analysis showed the following improvements in @entity6 , and @entity2 . The pattern of radiographic improvement in the @entity2 and FC/B subgroups showed significant improvement in each parameter when comparing preoperative to immediate postoperative values. Of importance, the radiographic findings comparing 1 month to the final follow-up showed little to no deterioration. Cotrel-Dubousset instrumentation proved to be a highly effective device for immediate restabilization of unstable thoracolumbar injuries.

title: Cotrel-Dubousset instrumentation and thoracolumbar spine XXXX : a review of 55 cases.

answer: @entity1


abstract: Several types of pedicular screw systems have been utilized to augment lumbar spine fusion. All systems are made of stainless steel, which interferes with imaging techniques, especially MRI and CT scans. In search of a solution for this problem, we decided to study the use of @entity6 systems in the lumbar spine. Because there were no @entity6 pedicle screw systems available on the market, we decided to use the @entity6 Alta system currently used for femur @entity5 . This report details our experience in using this device for lumbar spine fusion. From 1990 to 1992, 25 @entity0 underwent @entity7 and lumbar fusion with Alta @entity6 screws and plates. Spinal fusion was performed for a variety of conditions, including @entity1 , @entity5 , spondylolisthesis, @entity8 , and postdecompressive instability. All but two @entity0 obtained solid fusion clinically and radiographically and considerable improvement in back @entity3 . There was loosening of the implant in both @entity0 . Both @entity0 had @entity4 . One of these two @entity0 developed @entity8 , which required further surgery. The other @entity0 with a @entity1 of the spine remained asymptomatic without change in the spine alignment despite progression of the @entity2 . There were no broken screws encountered during follow-up. Two @entity0 sustained subsequent @entity5 of the vertebra above the fusion. One of the @entity0 also developed a @entity5 below the fusion. Fusion with @entity6 implants allowed postoperative evaluation and subsequent periodic examination of the spinal canal with high-quality MR images as well as significant reduction of artifacts on CT scan.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Use of XXXX implants in pedicular screw fixation.

answer: @entity6


abstract: OBJECTIVE: @entity2 ( @entity2 ) continues to be an underestimated disease with a lack of strict classification and diagnostic criteria. We present the analysis of a case series of 60 oral @entity2 @entity0 from 2 centers and illustrate the range of oral clinical presentations. STUDY DESIGN: Clinical data from 60 @entity2 @entity0 with oral involvement, diagnosed and treated between 1982 and 2014, were retrospectively collected from the archives of 2 independent hospitals. Statistical analyses of the data were performed using the Pearson   -squared test and the Mann-Whitney U test. RESULT: Thirty-one @entity0 (51.7%) were male and 29 (48.3%) were female, with a mean (  SD) age of 37.9  years (  18.1). The frequency of previous occurrences ranged from 0 to 10 (mean      SD: 1.4      2.0). Twenty-nine @entity0 (48%) had no previous occurrence. Medications (particularly antipyretics, food additives, and antibiotics) were the suspected precipitants in 28 @entity0 (46.7%), @entity1 was suspected in 18 (30.0%). All but 1 @entity0 had involvement of multiple oral sites, with the buccal mucosa being the most commonly involved oral site (75%), followed by the vermillion border (71.7%). CONCLUSIONS: @entity0 with @entity2 may present initially to oral health care workers. Medications and herpes simplex virus continue to be the most typically involved precipitating factors. Our data highlight the additional role of food-derived antigens. Although laboratory tests can provide support diagnostically, @entity2 diagnosis continues to be based on clinical features. A medication and food diary should be encouraged particularly in @entity0 with recurrent forms.

title: Oral XXXX : trends and clinical findings of a large retrospective European case series.

answer: @entity2


abstract: BACKGROUND: Cancer care nursing is perceived as personally and professionally demanding. Developing effective coping skills and resilience has been associated with better health and wellbeing for nurses, work longevity and improved quality of @entity0 care. OBJECTIVES: The objective of this systematic review was to identify personal and organizational strategies that promote coping and resilience in oncology and palliative care nurses caring for adult @entity0 with @entity1 . METHODS: The search strategy identified published and unpublished studies from 2007 to 2013. Individual search strategies were developed for the 12 databases accessed and search alerts established. The review considered qualitative, quantitative and mixed methods studies that assessed personal or organizational interventions, programs or strategies that promoted coping and resilience. These included studies employing clinical supervision, staff retreats, psycho-educational programs, compassion @entity2 resilience programs, stress inoculation therapy and individual approaches that reduced the emotional impact of @entity1 care work. The outcomes of interest were the experience of factors that influence an individual's coping and resilience and outcomes of validated measures of coping or resilience. Methodological quality of studies was independently assessed by two reviewers prior to inclusion in the review using standardized critical appraisal instruments developed by the Joanna Briggs Institute. Standardized Joanna Briggs Institute tools were also used to extract data. Agreement on the synthesis of the findings from qualitative studies was reached through discussion. The results of quantitative studies could not be statistically pooled given the different study designs, interventions and outcome measures. These studies were presented in narrative form. RESULTS: Twenty studies were included in the review. Ten studies examined the experience of nurse's caring for the dying, the emotional impact of palliative care and oncology work and strategies to prevent burnout or avoid compassion @entity2 , challenges in self-care, and processes nurses adopted to cope with work related stress. Six studies evaluated different interventions provided by organizations to improve coping and resilience. Evidence for the effectiveness of interventions was limited to three studies. The results are discussed under four headings: (i) preventative measures (ii) control measures (iii) unburdening and "letting go", and (iv) growing and thriving. CONCLUSION: This review identified a number of strategies to better prepare nurses for practice and maintain their psychological wellbeing. Although no firm conclusions can be drawn in respect to the most effective interventions, strategies with merit included those that: a) foster connections within the team; b) provide education and training to develop behaviors that assist in controlling or limiting the intensity of stress, or aiding recovery; and c) assist in processing emotion and learning from experiences. Although individuals must take responsibility for developing personal strategies to assist coping and resilience, organizational support is integral to equipping individuals to deal with work related challenges. IMPLICATIONS FOR PRACTICE: A range of formal and informal support is required to promote coping and resilience. IMPLICATIONS FOR RESEARCH: There is a need for large, well designed, multisite, experimental studies to evaluate the effectiveness of interventions that promote coping and resilience in adult palliative care or oncology nurses.

title: Strategies to promote coping and resilience in oncology and palliative care nurses caring for adult @entity0 with XXXX : a comprehensive systematic review.

answer: @entity1


abstract: BACKGROUND: Cancer care nursing is perceived as personally and professionally demanding. Developing effective coping skills and resilience has been associated with better health and wellbeing for nurses, work longevity and improved quality of @entity0 care. OBJECTIVES: The objective of this systematic review was to identify personal and organizational strategies that promote coping and resilience in oncology and palliative care nurses caring for adult @entity0 with @entity1 . METHODS: The search strategy identified published and unpublished studies from 2007 to 2013. Individual search strategies were developed for the 12 databases accessed and search alerts established. The review considered qualitative, quantitative and mixed methods studies that assessed personal or organizational interventions, programs or strategies that promoted coping and resilience. These included studies employing clinical supervision, staff retreats, psycho-educational programs, compassion @entity2 resilience programs, stress inoculation therapy and individual approaches that reduced the emotional impact of @entity1 care work. The outcomes of interest were the experience of factors that influence an individual's coping and resilience and outcomes of validated measures of coping or resilience. Methodological quality of studies was independently assessed by two reviewers prior to inclusion in the review using standardized critical appraisal instruments developed by the Joanna Briggs Institute. Standardized Joanna Briggs Institute tools were also used to extract data. Agreement on the synthesis of the findings from qualitative studies was reached through discussion. The results of quantitative studies could not be statistically pooled given the different study designs, interventions and outcome measures. These studies were presented in narrative form. RESULTS: Twenty studies were included in the review. Ten studies examined the experience of nurse's caring for the dying, the emotional impact of palliative care and oncology work and strategies to prevent burnout or avoid compassion @entity2 , challenges in self-care, and processes nurses adopted to cope with work related stress. Six studies evaluated different interventions provided by organizations to improve coping and resilience. Evidence for the effectiveness of interventions was limited to three studies. The results are discussed under four headings: (i) preventative measures (ii) control measures (iii) unburdening and "letting go", and (iv) growing and thriving. CONCLUSION: This review identified a number of strategies to better prepare nurses for practice and maintain their psychological wellbeing. Although no firm conclusions can be drawn in respect to the most effective interventions, strategies with merit included those that: a) foster connections within the team; b) provide education and training to develop behaviors that assist in controlling or limiting the intensity of stress, or aiding recovery; and c) assist in processing emotion and learning from experiences. Although individuals must take responsibility for developing personal strategies to assist coping and resilience, organizational support is integral to equipping individuals to deal with work related challenges. IMPLICATIONS FOR PRACTICE: A range of formal and informal support is required to promote coping and resilience. IMPLICATIONS FOR RESEARCH: There is a need for large, well designed, multisite, experimental studies to evaluate the effectiveness of interventions that promote coping and resilience in adult palliative care or oncology nurses.

title: Strategies to promote coping and resilience in oncology and palliative care nurses caring for adult XXXX with @entity1 : a comprehensive systematic review.

answer: @entity0


abstract: OBJECTIVES: To identify clinical and imaging features associated with complete response (CR) to first session of transarterial chemoembolization (TACE) with drug-eluting beads (DEB) in @entity0 with @entity3 . METHODS: In this prospective historical cohort, 172 @entity0 with 315 @entity1 who received at least one DEB-TACE from 2007 to 2013 were studied. Imaging response was evaluated according to the modified Response Evaluation Criteria in Solid Tumours (mRECIST). Age, gender, aetiology of @entity2 , @entity0 and BCLC scores, particles size, location in the liver, size of the @entity1 , presence of a capsule, hypervascularisation on DSA and CT/MRI scans, and blush extinction were analysed. RESULTS: After one session of treatment, CR was observed in 36  % of the 315 @entity1 treated. Nodule size, location in the liver, and complete blush extinction on DSA was statistically correlated to complete response, whereas capsule aspect on imaging and demographic criteria were not. In multivariate analysis only, location in the liver and nodule size were significant features. CONCLUSIONS: @entity1 location in the segments 1 and 4 is a pejorative factor for CR, whereas @entity1 size <5  cm is a positive predictive factor. These criteria could, therefore, be taken into consideration to improve the selection of @entity0 for DEB-TACE. KEY POINTS:     Literature on predictive factors of complete response after DEB-TACE is under-studied.     @entity1 size <5  cm is associated with complete response.     Location in segments 1 or 4 is a pejorative factor for response.     No demographic parameter influences complete response.

title: Predictive factors for complete response of chemoembolization with drug-eluting beads (DEB-TACE) for XXXX .

answer: @entity3


abstract: 1. The effects of alterations in @entity1 ( @entity1 ), as induced by vasoactive drugs, on heart rate (HR), basal @entity2 concentration and electrically evoked @entity2 overflow and on blood flow in the portal vein of freely moving @entity0 , were investigated. 2. By infusion of @entity4 or @entity5 (0.5, 1.0 and 2.5 micrograms kg-1 min-1), @entity1 was altered over a range of 50 to 150 mmHg. The resulting changes in HR showed a sigmoidal relationship with @entity1 . @entity2 overflow increased linearly when @entity1 was decreased; when @entity1 was increased, however, @entity2 levels only decreased to 70% and reached a plateau from 125 mmHg onwards. 3. @entity4 (2.5 micrograms kg-1 min-1) and @entity6 (0.25 mg kg-1) decreased @entity1 to the same extent (-46 mmHg). HR and basal @entity2 concentration, however, were increased to a higher extent by @entity6 (+192 beats min-1; +373 pg ml-1, respectively) than by @entity4 (+78 beats min-1; +206 pg ml-1, respectively). Electrically evoked overflow was not changed at all after @entity4 , whereas @entity6 induced an increase to 206% of control. 4. @entity5 (2.5 micrograms kg-1 min-1) and @entity3 ) increased @entity1 to the same extent (to 155 and 161 mmHg, respectively). Basal @entity2 concentration decreased by 30% after @entity5 , whereas @entity3 increased @entity2 levels to 226% of control. Evoked @entity2 overflow was not changed after @entity5 but was increased to 204% of control after @entity3 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Influence of the baroreceptor reflex on the modulation of XXXX overflow through prejunctional receptors in the portal vein of freely moving @entity0 .

answer: @entity2


abstract: 1. The effects of alterations in @entity1 ( @entity1 ), as induced by vasoactive drugs, on heart rate (HR), basal @entity2 concentration and electrically evoked @entity2 overflow and on blood flow in the portal vein of freely moving @entity0 , were investigated. 2. By infusion of @entity4 or @entity5 (0.5, 1.0 and 2.5 micrograms kg-1 min-1), @entity1 was altered over a range of 50 to 150 mmHg. The resulting changes in HR showed a sigmoidal relationship with @entity1 . @entity2 overflow increased linearly when @entity1 was decreased; when @entity1 was increased, however, @entity2 levels only decreased to 70% and reached a plateau from 125 mmHg onwards. 3. @entity4 (2.5 micrograms kg-1 min-1) and @entity6 (0.25 mg kg-1) decreased @entity1 to the same extent (-46 mmHg). HR and basal @entity2 concentration, however, were increased to a higher extent by @entity6 (+192 beats min-1; +373 pg ml-1, respectively) than by @entity4 (+78 beats min-1; +206 pg ml-1, respectively). Electrically evoked overflow was not changed at all after @entity4 , whereas @entity6 induced an increase to 206% of control. 4. @entity5 (2.5 micrograms kg-1 min-1) and @entity3 ) increased @entity1 to the same extent (to 155 and 161 mmHg, respectively). Basal @entity2 concentration decreased by 30% after @entity5 , whereas @entity3 increased @entity2 levels to 226% of control. Evoked @entity2 overflow was not changed after @entity5 but was increased to 204% of control after @entity3 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Influence of the baroreceptor reflex on the modulation of @entity2 overflow through prejunctional receptors in the portal vein of freely moving XXXX .

answer: @entity0


abstract: BACKGROUND: Whilst many recent reports have suggested a rise in the prevalence of @entity2 and @entity0 in Western countries, little is known about the epidemiology of these common conditions in south-east Asia. This study compared the prevalence of @entity2 and @entity0 amongst secondary school students in three south-east Asian populations--Hong Kong, Kota Kinabalu in Malaysia, and San Bu in China--and investigated the associations with atopy and family history. METHODS: Secondary school students were given standard questionnaires on respiratory and @entity0 for completion by parents with response rates of 89.2% in Hong Kong (611 male, 451 female; mean (SD) age = 13.9 (1.8 years), 87.6% in Kota Kinabalu (134 male, 275 female; 15.5 (2.1) years), and 98.6% in San Bu (492 male, 245 female; 16.4 (1.8) years). Skin tests were performed in a subsample of students to determine @entity4 status. RESULTS: The respective prevalence (and 95% CI) for @entity5 , @entity1 , and wheeze or @entity2 were 15.7% (13.5, 17.9), 20.1% (17.7, 22.5), 11.6% (9.3, 13.9) in Hong Kong, 11.2% (8.2, 14.3), 7.6% (5.0, 10.1), 8.2% (5.5, 10.9) in Kota Kinabalu, and 2.1% (1.2, 3.1), 7.2% (5.4, 9.1), 1.9% (0.7, 3.1) in San Bu. Atopy was common and was present in 49.0-63.9% of subjects in the three populations. Dust mite and cockroach were the commonest allergens that gave positive reactions in 42.8-60.5% and 25.7-35.9% of students respectively. A higher proportion of students in Hong Kong had severe degree of reactivity on skin test than the other two populations. Family history was associated with @entity2 and @entity0 in the three populations conferring a 3-80-fold increase in risk to family members and was a stronger predictor for @entity2 and @entity3 than atopy. CONCLUSIONS: Prevalence of @entity2 and @entity0 is low compared with Western countries, but considerable differences exist between the three south-east Asian populations despite similar rates of atopy. @entity0 are more strongly associated with family history than atopy, which suggests that genetic and environmental factors common to the family, other than aeroallergen sensitisation, are important in the pathogenesis of @entity2 and @entity3 in the region.

title: Asthma, XXXX , and atopy in three south-east Asian populations.

answer: @entity3


abstract: Three groups of @entity0 were reviewed. Primary @entity5 were found in donors kidneys of 47 recipients. In 30 instances a @entity2 was present at harvesting. When a @entity2 was removed immediately pretransplantation or early posttransplantation there were no recurrences in 14 recipients. In another two instances, a @entity2 was not removed or was incompletely excised pretransplantation and both recipients died of @entity1 . Fourteen other @entity0 received kidneys from donors in whom the opposite kidney had a @entity2 . Thirteen remained @entity2 -free and one had allograft nephrectomy for rejection 3 months posttransplantation when a @entity5 was found. In 17 recipients an allograft @entity2 was not recognized at harvesting. In 9 it was discovered at graft nephrectomy an average of 3 months posttransplantation. In a tenth @entity0 a hypoechogenic area, found on routine posttransplant ultrasonography, progressively increased in size and proved to be malignant. Another 7 @entity0 developed @entity1 from @entity6 an average of 12 months posttransplantation. Preexisting @entity5 were found in 350 recipients. Seventy-one @entity0 with incidentally discovered @entity2 had no recurrences no matter when nephrectomy was performed in relationship to transplantation. Of 279 @entity0 with symptomatic @entity6 , 70 (25%) had recurrences, 63% of which occurred in @entity0 treated < or = 2 years pretransplantation. @entity2 were found posttransplantation in 256 recipients. @entity6 were 4.6% of posttransplant @entity2 compared with 3% of @entity2 in the general population. In 222 @entity0 their own diseased kidneys were involved, in 24 @entity2 occurred in the allograft, and in 10 cases the site was not stated. Development of @entity2 seemed to be related not to the immunosuppressive therapy but to the underlying cause of @entity4 , especially analgesic @entity3 . A disproportionate number of @entity5 (15%) involved the @entity3 , most likely because of prior analgesic abuse.

title: Primary XXXX before and after renal transplantation.

answer: @entity6


abstract: Aim. The present study aims to investigate the effects of nourishing "Yin" removing "Fire" (NYRF) @entity2 on puberty onset and hypothalamic @entity3 expression in female @entity0 . Materials and Methods. Forty female 20-day-old @entity0 were randomly divided into @entity2 ( @entity2 ) and @entity4 ( @entity4 ) groups. @entity0 in @entity2 and @entity4 were treated with NYRF mixture and @entity4 , respectively, from d22. @entity0 in each group were sacrificed on d28, d31, and d34. Serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and @entity1 (E2) levels were analyzed by ELISA. Hypothalamic @entity3 mRNA expression levels were determined by RT-PCR and hypothalamic p- @entity3 protein levels were assayed by western blot. Results. The vaginal opening time in @entity2 group was significantly delayed (P < 0.05). On d31, in comparison with @entity4 group, the coefficients of uteri and ovaries, levels of serum LH and E2, and the expression levels of hypothalamic @entity3 mRNA and p- @entity3 protein were significantly lower in @entity2 group (P < 0.05). Conclusion. The mechanism by which the nourishing "Yin" removing "Fire" @entity2 delays puberty onset may be associated with the inhibition of the hypothalamic @entity3 signaling.

title: Effect of Nourishing "Yin" Removing "Fire" Chinese Herbal Mixture on Hypothalamic Mammalian Target of Rapamycin Expression during Onset of Puberty in Female XXXX .

answer: @entity0


abstract: Two experiments were conducted to investigate the effect of intravenous injections of bacterial endotoxin in broiler chicks. In both experiments 5-weeks-old chicks were given a single intravenous injection of either distilled water (control) or 1 mg/kg @entity2 endotoxin (serotype 0.127:B8) in a volume of 1 mg/kg. In Experiment 1 rectal body temperatures were taken every hour for 24 hr postinjection. In Experiment 2, rectal temperatures and blood samples were taken at 3, 6, 9, 12, 15, and 24 hr following the administration of endotoxin. Hematocrits and plasma @entity0 , protein, @entity4 , @entity3 , @entity5 , @entity1 , and inorganic @entity6 were measured at each time interval. Birds receiving endotoxin showed a significant increase in rectal temperature from 2 hr until 17 hr postinjection. The febrile response was biphasic with temperatures peaking at 3 to 5 hr and again at 9 to 12 hr. No significant changes in hematocrits occurred following endotoxin injection. Plasma protein, @entity3 , and @entity1 decreased significantly, while @entity0 increased significantly after endotoxin administration. No significant changes in plasma @entity5 , @entity4 , or inorganic @entity6 were observed in endotoxin-treated chicks.

title: Rectal temperature and blood chemical responses of young chickens given XXXX endotoxin.

answer: @entity2


abstract: BACKGROUND: The current study compared the immunocytochemical expression of @entity2 (ER) and @entity4 ( @entity6 ) receptors by malignant breast cells to the hormone receptor concentrations reported from radioligand assays. These values were examined in relation to DNA ploidy and the fraction of cells in S phase. METHODS: ER and @entity6 concentrations, DNA ploidy, and S-phase fractions were measured by standard techniques with 124 samples of @entity3 . Suspensions of @entity1 cells were examined by immunocytochemical assay (ICA) for the percentages of ER and @entity6 positive cells. RESULTS: Twenty-six of the 38 @entity1 from @entity0 50 years of age or younger were classified as high S-phase fraction, and 28 @entity1 had aneuploid levels of DNA. The 20 ER positive @entity1 each contained less than 100 fmol/mg. Thirty-nine of the 86 @entity1 from @entity0 older than 50 years were classified as high S phase, and 41 were aneuploid. Sixty-five samples were considered ER positive by radioligand assay. ICA showed that @entity1 in either age group with less than 40 fmol/mg did not contain ER positive cells. The proportion of samples with @entity6 levels between 10 and 100 fmol/mg was small, and fewer @entity6 positive @entity1 were categorized as negative when examined by ICA for receptor containing cells. The reclassification of the hormone receptor status of a @entity1 based on @entity5 appeared to be independent of S-phase and ploidy values. CONCLUSIONS: Tumors that are classified as ER or @entity6 positive based on accepted cutoff values for radioligand assays may actually be receptor negative because the @entity1 do not appear to contain receptor positive cells.

title: Relationship between low XXXX receptor values and other prognostic factors in primary breast tumors.

answer: @entity2


abstract: BACKGROUND: The ideal method for the surgical treatment of @entity3 has not yet been found. We therefore conducted a retrospective matched-pair analysis and compared osteosynthesis with open reduction and internal fixation and that with an angular stable plate with minimally invasive, closed reduction, percutaneous fixation with the Humerusblock. METHODS: During a study period of 3  years, we matched 30 @entity0 treated with angular stable plates (group 1) for age, gender, fracture type and handedness (dominant or nondominant) to 30 @entity0 treated using the Humerusblock (group 2). At a minimal follow-up of 24  months, clinical evaluation included the Constant-Murley score, the UCLA score and the Simple Shoulder Test. Subjective @entity1 was evaluated using the VAS @entity1 scale. @entity0 were asked to rate their subjective satisfaction of final outcome as excellent, good, satisfied or dissatisfied. RESULTS: The mean CMS, UCLA score and SST differed significantly between groups 1 and 2 (60.9 vs 71.9, p   <   0.01), (25.1 vs 29.5, p   <   0.01) and (8.1 vs 9.4, p   <   0.05), respectively. The VAS @entity1 score was significantly lower in group 2 than in group 1 (1.2 vs 2.4; p   <   0.01). The mean abduction (109.7   vs 133.7  ; p   <   0.01) and anterior flexion (128.3   vs 145.7  ; p   <   0.01) were significantly worse in group 1. The mean operation time was significantly shorter in group 2 (117.3 vs 72.1, p   <   0.01). Complications occurred in 30  % (group 1) and 23  % (group 2) of @entity0 . CONCLUSIONS: In this study, the functional outcome is superior in the Humerusblock group. However, the general outcome after surgical treatment of 3-and 4-part @entity2 is moderate, and the complication rate has to be considered, even though it can be lowered with the use of minimally invasive implants.

title: Comparison between minimally invasive, percutaneous osteosynthesis and locking plate osteosynthesis in 3-and 4-part proximal humerus XXXX .

answer: @entity2