abstract: @entity9 from the hyperthermophilic archaeon @entity7 ( @entity10 ) carries the aminoacyl tRNA to the ribosome; it binds @entity2 or @entity3 , and it is also endowed with an intrinsic GTPase activity that is triggered in vitro by @entity0 at molar concentrations [Masullo, M., De Vendittis, E., and Bocchini, V. (1994) J. Biol. Chem. 269, 20376-20379]. The structural properties of @entity10 were investigated by Fourier transform infrared spectroscopy. The estimation of the secondary structure of the @entity10 * @entity2 complex, made by curve fitting of the @entity5 I' band or by factor analysis of the @entity5 I band, indicated a content of 34-36% alpha-helix, 35-40% beta-sheet, 14-19% turn, and 7% unordered structure. The substitution of the @entity2 bound with the slowly hydrolyzable GTP analogue Gpp(NH)p induced a slight increase in the alpha-helix and beta-sheet content. On the other hand, the alpha-helix content of the @entity10 * @entity2 complex increased upon addition of salts, and the highest effect was produced by 5 M @entity0 . The thermal stability of the @entity10 * @entity2 complex was significantly reduced when the @entity2 was replaced with Gpp(NH)p or in the presence of @entity8 or @entity6 , whereas a lower destabilizing effect was provoked by @entity0 and @entity4 . Therefore, the extent of the destabilizing effect of salts depended on the nature of both the cation and the anion. The data suggested that the @entity1 ion was responsible for the induction of the GTPase activity, whereas the anion modulated the enzymatic activity through destabilization of particular regions of @entity10 . Finally, the infrared data suggested that, in particular region(s) of the polypeptide chain, the @entity10 *Gpp(NH)p complex possesses structural conformations which are different from those present in the @entity10 * @entity2 complex.

title: Salts induce structural changes in XXXX from the hyperthermophilic archaeon @entity7 : a Fourier transform infrared spectroscopic study.

answer: @entity9


abstract: @entity9 from the hyperthermophilic archaeon @entity7 ( @entity10 ) carries the aminoacyl tRNA to the ribosome; it binds @entity2 or @entity3 , and it is also endowed with an intrinsic GTPase activity that is triggered in vitro by @entity0 at molar concentrations [Masullo, M., De Vendittis, E., and Bocchini, V. (1994) J. Biol. Chem. 269, 20376-20379]. The structural properties of @entity10 were investigated by Fourier transform infrared spectroscopy. The estimation of the secondary structure of the @entity10 * @entity2 complex, made by curve fitting of the @entity5 I' band or by factor analysis of the @entity5 I band, indicated a content of 34-36% alpha-helix, 35-40% beta-sheet, 14-19% turn, and 7% unordered structure. The substitution of the @entity2 bound with the slowly hydrolyzable GTP analogue Gpp(NH)p induced a slight increase in the alpha-helix and beta-sheet content. On the other hand, the alpha-helix content of the @entity10 * @entity2 complex increased upon addition of salts, and the highest effect was produced by 5 M @entity0 . The thermal stability of the @entity10 * @entity2 complex was significantly reduced when the @entity2 was replaced with Gpp(NH)p or in the presence of @entity8 or @entity6 , whereas a lower destabilizing effect was provoked by @entity0 and @entity4 . Therefore, the extent of the destabilizing effect of salts depended on the nature of both the cation and the anion. The data suggested that the @entity1 ion was responsible for the induction of the GTPase activity, whereas the anion modulated the enzymatic activity through destabilization of particular regions of @entity10 . Finally, the infrared data suggested that, in particular region(s) of the polypeptide chain, the @entity10 *Gpp(NH)p complex possesses structural conformations which are different from those present in the @entity10 * @entity2 complex.

title: Salts induce structural changes in @entity9 from the hyperthermophilic archaeon XXXX : a Fourier transform infrared spectroscopic study.

answer: @entity7


abstract: The training intensity may affect the monocarboxylate transporters @entity3 and @entity4 in skeletal muscle. Therefore, 20 elite cross-country skiers (11 @entity0 and nine @entity0 ) trained hard for 5 months at either moderate ( @entity1 , 60-70% of VO2max) or high intensity (HIG, 80-90%). The @entity2 threshold, several performance parameters, and the blood @entity2 concentration ( @entity5 ) after exhausting treadmill running were also determined. Muscle biopsies taken from the vastus lateralis muscle before and after the training period were analysed for the two MCTs and for muscle fibre types and six enzymes. The concentration of @entity3 did not change for HIG (P=0.3) but fell for @entity1 (-12 +/- 3%, P=0.01); the training response differed between the two groups (P=0.05). The concentration of @entity4 did not change during the training period (P > 0.10). The concentration of the two MCTs did not differ between the two sexes (P=0.9). The running speed at the @entity2 threshold rose for HIG (+3.2 +/- 0.9%, P=0.003), while no change was seen for @entity1 (P=0.54); the training response differed between the two groups (P=0.04). The @entity5 after long-lasting exhausting treadmill running correlated with the concentration of @entity3 (rs=0.69, P=0.002), but not with that of @entity4 (rs=0.2, P=0.2). There were no other significant correlations between the concentrations of the two MCTs and the performance parameters, muscle fibre types, or enzymes (r < or = 0.36, P > 0.10). Thus, the training response differed between @entity1 and HIG both in terms of performance and of the effect on @entity3 . Training at high intensity may be more effective for cross-country skiers. Finally, @entity3 may be important for releasing @entity2 to the blood during long-lasting exercise.

title: Effect of training intensity on muscle XXXX transporters and @entity2 threshold of cross-country skiers.

answer: @entity2


abstract: The training intensity may affect the monocarboxylate transporters @entity3 and @entity4 in skeletal muscle. Therefore, 20 elite cross-country skiers (11 @entity0 and nine @entity0 ) trained hard for 5 months at either moderate ( @entity1 , 60-70% of VO2max) or high intensity (HIG, 80-90%). The @entity2 threshold, several performance parameters, and the blood @entity2 concentration ( @entity5 ) after exhausting treadmill running were also determined. Muscle biopsies taken from the vastus lateralis muscle before and after the training period were analysed for the two MCTs and for muscle fibre types and six enzymes. The concentration of @entity3 did not change for HIG (P=0.3) but fell for @entity1 (-12 +/- 3%, P=0.01); the training response differed between the two groups (P=0.05). The concentration of @entity4 did not change during the training period (P > 0.10). The concentration of the two MCTs did not differ between the two sexes (P=0.9). The running speed at the @entity2 threshold rose for HIG (+3.2 +/- 0.9%, P=0.003), while no change was seen for @entity1 (P=0.54); the training response differed between the two groups (P=0.04). The @entity5 after long-lasting exhausting treadmill running correlated with the concentration of @entity3 (rs=0.69, P=0.002), but not with that of @entity4 (rs=0.2, P=0.2). There were no other significant correlations between the concentrations of the two MCTs and the performance parameters, muscle fibre types, or enzymes (r < or = 0.36, P > 0.10). Thus, the training response differed between @entity1 and HIG both in terms of performance and of the effect on @entity3 . Training at high intensity may be more effective for cross-country skiers. Finally, @entity3 may be important for releasing @entity2 to the blood during long-lasting exercise.

title: Effect of training intensity on muscle @entity2 transporters and XXXX threshold of cross-country skiers.

answer: @entity2


abstract: BACKGROUND: Long-term acid suppression is believed to accelerate @entity6 in @entity4 -positive @entity0 . The influence of long-term therapy with @entity7 has not been examined. AIM: To study the clinical and endoscopic efficacy and histological evolution of gastric mucosa during 5 years of maintenance treatment with @entity7 , 30 mg. METHODS: Seventy-eight @entity0 with endoscopically proven @entity3 were followed for 5 years. Biopsies taken at the start of the study, during follow-up and after 5 years were available for 73 @entity0 . RESULTS: The total endoscopic relapse rate was 14.1%. At the start of the study, 34 @entity0 were @entity4 negative and 39 were @entity4 positive (two @entity2 , 25 antral @entity5 , 12 pangastritis). At 5 years, no histological changes had occurred in @entity4 -negative @entity0 . In the @entity4 -positive group, 20 @entity0 developed pangastritis, six had normal histology and one had antral @entity5 . Ten of the 12 @entity0 with pangastritis had reduced antral activity. There was no increase in intestinal metaplasia, but there was a tendency towards regression of @entity2 in the antrum and towards increased @entity2 in the body of the stomach. CONCLUSIONS: Maintenance treatment with @entity7 , 30 mg, is efficacious. The development of @entity2 and intestinal metaplasia was not accelerated in @entity4 -positive @entity0 . @entity4 eradication must be considered only because of the higher @entity1 risk associated with chronic @entity4 -related @entity5 .

title: Long-term @entity7 treatment for XXXX : clinical efficacy and influence on gastric mucosa.

answer: @entity3


abstract: BACKGROUND: Long-term acid suppression is believed to accelerate @entity6 in @entity4 -positive @entity0 . The influence of long-term therapy with @entity7 has not been examined. AIM: To study the clinical and endoscopic efficacy and histological evolution of gastric mucosa during 5 years of maintenance treatment with @entity7 , 30 mg. METHODS: Seventy-eight @entity0 with endoscopically proven @entity3 were followed for 5 years. Biopsies taken at the start of the study, during follow-up and after 5 years were available for 73 @entity0 . RESULTS: The total endoscopic relapse rate was 14.1%. At the start of the study, 34 @entity0 were @entity4 negative and 39 were @entity4 positive (two @entity2 , 25 antral @entity5 , 12 pangastritis). At 5 years, no histological changes had occurred in @entity4 -negative @entity0 . In the @entity4 -positive group, 20 @entity0 developed pangastritis, six had normal histology and one had antral @entity5 . Ten of the 12 @entity0 with pangastritis had reduced antral activity. There was no increase in intestinal metaplasia, but there was a tendency towards regression of @entity2 in the antrum and towards increased @entity2 in the body of the stomach. CONCLUSIONS: Maintenance treatment with @entity7 , 30 mg, is efficacious. The development of @entity2 and intestinal metaplasia was not accelerated in @entity4 -positive @entity0 . @entity4 eradication must be considered only because of the higher @entity1 risk associated with chronic @entity4 -related @entity5 .

title: Long-term XXXX treatment for @entity3 : clinical efficacy and influence on gastric mucosa.

answer: @entity7


abstract: BACKGROUND: Polyoma @entity4 in renal transplant recipients has been observed with increasing frequency in recent years. Renal allograft involvement in this condition may occur as a result of @entity2 or secondary to reactivation of the latent virus. @entity9 , @entity8 , rise in serum @entity5 and allograft function loss have been attributed to this @entity7 . METHODS: In this study we reviewed our experience with 8 @entity0 who developed polyoma @entity7 confirmed by allograft biopsy. All @entity0 were receiving @entity3 as part of the immunosuppression and 7 of the 8 @entity0 were on @entity6 . All @entity0 have biopsy proven polyoma @entity7 . The following therapeutic maneuvers were carried out following the diagnosis of polyoma @entity7 : 1) stopping mycophenolate and 2) switching @entity6 to @entity1 or reducing the @entity6 dose to adjust it at a lower therapeutic trough level. The clinical course and outcome of our @entity0 were reviewed in relation to manipulation of immunosuppressive medications. RESULTS: The incidence of this infection in our transplant program in the last 3 yr was 5.3%. Seventy-five percent of the @entity0 had at least one rejection episode and 63% had more than one rejection episode. The main risk factor for the development of polyoma @entity7 was related to the intensity of immunosuppression. The use of antirejection therapy after histological diagnosis of @entity4 was not associated with improvement of renal function despite the histological appearance of acute rejection. Thus, the @entity9 associated with polyoma @entity7 appears to be an inflammatory response to the virus rather than acute rejection. Six out of the 8 @entity0 stabilized renal function with reduction in immunosuppression. CONCLUSIONS: Reduction in immunosuppression was associated with the stabilization of renal function when instituted early. However, these @entity0 were left with a degree of allograft dysfunction and their outcome may be significantly compromised. The lack of effective antiviral therapy for polyoma virus may limit the use of newer and more potent immunosuppressive medications.

title: Polyoma XXXX in renal transplantation: the role of immunosuppressive therapy.

answer: @entity7


abstract: Many aspects of retinal physiology are controlled by a circadian clock located within the eye. This clock controls the rhythmic synthesis of @entity4 , which results in elevated levels during the night and low levels during the day. The rate-limiting enzyme in @entity4 biosynthesis in retina appears to be @entity3 hydroxylase (TPH)[G.M. Cahill and J.C. Besharse, Circadian regulation of @entity4 in the retina of @entity1 : Limitation by @entity0 availability, J. Neurochem. 54 (1990) 716-719]. In this report, we found that TPH mRNA is strongly expressed in the photoreceptor layer and the vitread portion of the inner nuclear layer; the message is also expressed, but to a lesser extent, in the ganglion cell layer. The abundance of retinal TPH mRNA exhibits a circadian rhythm which persists in constant light or constant darkness. The phase of the rhythm can be reversed by reversing the light:dark cycle. In parallel experiments we found a similar pattern of expression in the @entity2 pineal gland. However, whereas a pulse of light at midnight suppressed retinal TPH mRNA by 25%, it did not alter pineal TPH mRNA, suggesting that there are tissue-specific differences in photic regulation of TPH mRNA. In retinas treated with @entity5 to destroy @entity0 -containing amacrine and bipolar cells, a high amplitude rhythm of TPH mRNA was observed indicating that @entity4 -synthesizing photoreceptors are the primary source of the rhythmic message. These observations provide the first evidence that @entity2 retinal TPH mRNA is under control of a circadian clock.

title: Circadian expression of XXXX hydroxylase mRNA in the @entity2 retina.

answer: @entity3


abstract: Many aspects of retinal physiology are controlled by a circadian clock located within the eye. This clock controls the rhythmic synthesis of @entity4 , which results in elevated levels during the night and low levels during the day. The rate-limiting enzyme in @entity4 biosynthesis in retina appears to be @entity3 hydroxylase (TPH)[G.M. Cahill and J.C. Besharse, Circadian regulation of @entity4 in the retina of @entity1 : Limitation by @entity0 availability, J. Neurochem. 54 (1990) 716-719]. In this report, we found that TPH mRNA is strongly expressed in the photoreceptor layer and the vitread portion of the inner nuclear layer; the message is also expressed, but to a lesser extent, in the ganglion cell layer. The abundance of retinal TPH mRNA exhibits a circadian rhythm which persists in constant light or constant darkness. The phase of the rhythm can be reversed by reversing the light:dark cycle. In parallel experiments we found a similar pattern of expression in the @entity2 pineal gland. However, whereas a pulse of light at midnight suppressed retinal TPH mRNA by 25%, it did not alter pineal TPH mRNA, suggesting that there are tissue-specific differences in photic regulation of TPH mRNA. In retinas treated with @entity5 to destroy @entity0 -containing amacrine and bipolar cells, a high amplitude rhythm of TPH mRNA was observed indicating that @entity4 -synthesizing photoreceptors are the primary source of the rhythmic message. These observations provide the first evidence that @entity2 retinal TPH mRNA is under control of a circadian clock.

title: Circadian expression of @entity3 hydroxylase mRNA in the XXXX retina.

answer: @entity2


abstract: Right ventricular restrictive physiology is common after repair of @entity2 and relates to exercise performance and symptomatic @entity5 . In this study, we examined biventricular long axis function in an attempt to clarify further the mechanical substrate of this phenomenon. We studied prospectively 95 @entity0 with @entity2 (age range 1-44.3 years) at a median of 4.3 years after repair with Doppler and M-mode echocardiography. Pulmonary arterial, tricuspid, and mitral Doppler spectrals and 2-D guided M-mode recordings of ventricular minor and long axes were obtained with simultaneous phonocardiogram and respirometer recordings. Right ventricular restriction was defined by the presence of antegrade pulmonary arterial flow during atrial systole throughout the respiratory cycle. Restrictive right ventricular physiology was demonstrated in 36 (39%) [group 1] of the 92 @entity0 in whom the data were analyzed. Left ventricular function (FS, isovolumic relaxation time and transmitral E wave deceleration time) was not different in the two groups (p < 0.1, p < 0.6, and p < 0.8, respectively). The presence of antegrade diastolic flow shortened the @entity3 in the restrictive group (PR duration/square root of RR 10.7 +/- 2.1 vs 12.1 +/- 2.1, p < 0.01). There was delayed onset of shortening (97.4 +/- 24 vs 88.8 +/- 24 ms, p = 0.01), and the amplitude of right @entity4 , corrected for body surface area, was significantly lower during atrial systole in the restrictive group (0.43 +/- 0.15 vs 0.54 +/- 0.2 cm/m2, p < 0.01). There was also a tendency toward a smaller ratio of right to left total @entity4 in the same group (1.14 +/- 0.19 vs 1.22 +/- 0.23, p = 0.1). @entity1 function in @entity0 with restrictive right ventricular physiology following repair of @entity2 is associated with abnormal diastolic filling and may contribute to the long-term cardioprotective effect of restrictive physiology by limiting the degree of @entity6 .

title: Biventricular long axis function after repair of XXXX .

answer: @entity2


abstract: The purpose of study was to determine the @entity1 value through beta-carotene analysis of five Brazilian leafy vegetables: @entity0 leaves ( @entity0 .), beet leaves (Beta vulgaris L.) "serralha" (Sonchus oleracea L.), mint (Mentha piperita LL.) and celery leaves (Aplum graveolens. L.). Two analysis methods were used: open-column chromatography (OCC) and high performance liquid chromatography (HPLC). Two analysis methods were used: open-column chromatography (OCC) and high performance liquid chromatography (HPLC). Recovery tests were done for both methods and 92% of recovery was obtained for OCC and for HPLC 102%. The @entity1 value obtained for these leaves, using OCC were: 491 RE/100 g for @entity0 , 1097 for beet, 1390 for "serralha", 1016 for mint and 911 for celery. The results obtained using HPLC were 495 RE/100 g for @entity0 leaves, 1095 for beet leaves, 1472 for "serralha" leaves, 940 for mint leaves and 908 for celery leaves. We concluded that both methods presented good recoveries, are similar for determination of @entity1 in the leaves and they can be used for routine analysis. These five leaves can be as an inexpensive and easily obtained sources of @entity1 in Brazil.

title: Determination of XXXX of green leafy vegetables by high performance liquid chromatography and open column chromatography.

answer: @entity1


abstract: Community health education played a major role in a study of @entity3 ( @entity3 ) and other @entity4 which we conducted in rural and periurban communities of the Asaro Valley near Goroka in the Eastern Highlands Province of Papua New Guinea. We found that most @entity0 had little knowledge about @entity3 , which they often did not realize were sexually transmitted. Even major signs and symptoms were thought to be normal and many @entity0 had not sought treatment until irreversible damage was done. Knowledge of the complications of @entity3 , such as @entity1 and @entity2 , was also slight in these @entity0 . It is apparent that there is a desperate need for more reproductive health education at the community level. In developing our health education methods, we found that simple line drawings of male and female reproductive organs and of @entity0 with different signs of @entity3 proved useful. These were quick and easy to produce from readily available materials. It was important to separate @entity0 and @entity0 into different groups with educators of the same sex, and to create a very informal atmosphere, encouraging free-ranging discussion. Following health education and sensitive interviewing, almost all the @entity0 selected for the community-based study of the prevalence of @entity4 consented to vaginal examination, even if they were asymptomatic. Additionally, many nonselected @entity0 requested examination.

title: Knowledge about XXXX in rural and periurban communities of the Asaro Valley of Eastern Highlands Province: the health education component of an STD study.

answer: @entity3


abstract: It was the aim of the present study to investigate the effects of the acute phase protein alpha 1-acid glycoprotein in different models of @entity7 . The @entity0 plasma preparation used was without effect on mortality in lipopolysaccharide-injected @entity1 when administered in two different doses (1 or 0.33 g/kg i.v.) and according to different treatment schedules. The same preparation significantly increased survival rate (48 h) in @entity2 with @entity5 . This effect was seen when alpha 1-acid glycoprotein (200 mg/kg i.v.) was given 15 min prior to and 24 h after cecal puncture. All other dose regimes tested were without significant effect on survival rate. A @entity6 / @entity7 model (including a defined @entity4 ) in @entity2 resuscitated with 200 mg/kg alpha 1-acid glycoprotein resulted in significantly higher values of mean arterial blood pressure, cardiac output and @entity3 volume when compared to corresponding values obtained after resuscitation with Ringer's solution or 200 mg/kg albumin i.v. (free of alpha 1-acid glycoprotein; placebo formulation). Taking all other possible mechanisms of alpha 1-acid glycoprotein into consideration, the partially protective effects of the preparation are explained by enhancing the capillary barrier function and thereby maintaining perfusion of vital organs.

title: Effects of alpha 1-acid glycoprotein in different rodent models of XXXX .

answer: @entity7


abstract: OBJECTIVE: To develop, implement and evaluate a practice guideline for stress @entity2 . DESIGN: Before-after study. SETTING: Ten-bed Intensive Care Unit (ICU) and 4-bed Step-down Unit in a teaching hospital. @entity0 AND @entity0 : Fifty @entity0 admitted during 1 year before and 50 @entity0 admitted 3-6 months after introduction of the guideline. INTERVENTION: Introduction of the practice guideline by dissemination of pocket cards, seminars and " @entity4 ". MEASUREMENTS AND RESULTS: Appropriateness (defined as proportion of days in which the prophylaxis met the criteria in the guideline), incidence of @entity1 and of @entity3 , length of stay in ICU and in hospital, ventilator days. ICU mortality and medication costs for stress @entity2 . After the introduction of the guideline, appropriateness increased from 75.8% to 91.1%, and medication costs decreased from C  2.50/day to C  1.30/day. There were no differences in any clinical outcomes. Predictors of appropriate use or the withholding of prophylaxis were the introduction of the guideline, lack of an indication for prophylaxis and number of days studied. CONCLUSIONS: Introduction of this guideline was associated with an increase in appropriateness of prophylaxis and a decrease in medication costs.

title: Implementation of a clinical practice guideline for stress XXXX increases appropriateness and decreases cost of care.

answer: @entity2


abstract: The specific motility patterns of the forestomach of ruminants, composed of three structurally distinct compartments (rumen, reticulum, omasum), require an elaborate intramural innervation. To demonstrate the complex structure of the enteric nervous system (ENS), whole mount preparations obtained from different sites of the @entity1 forestomach were submitted to immunohistochemical procedures in which neuronal (protein gene product 9.5, neurofilament 200) and glial (protein S-100, glial fibrillary acid protein) markers were applied. Immunohistochemistry performed on whole mounts allowed a detailed two-dimensional assessment of the architecture of the intramural nerve networks. Generally, the myenteric and submucosal plexus layers were composed of @entity0 and interconnecting nerve fiber strands, whereas the mucosal plexus consisted of an aganglionated nerve network. However, the texture of the ENS showed considerable regional differences concerning the ganglionic size, shape and density and the arrangement of nerve fiber strands. The myenteric plexus of the ruminal wall, showing a low ganglionic density and wide polygonal meshes, contrasted with the nerve network within the ruminal pillar which consisted of ropeladder-like nerve fiber strands and parallel orientated @entity0 . The highest ganglionic density was observed at the reticular groove, the most prominent @entity0 were found within the omasal wall. Branches of the vagal nerve frequently ramified within the myenteric plexus layers. The submucosal plexus of the rumen was divided into an external and internal layer; the reticular submucosal plexus followed the cristae and cellulae reticuli, the omasal submucosal (sublaminar) plexus showed intra- and parafascicular @entity0 apart from @entity0 located at the junctions of the nerve network. The mucosal plexus of the rumen consisted of thin nerve fascicles ramifying between the ruminal papillae, and reticular mucosal nerve fibers passed throughout the base of the cellulae reticuli. The highly specialised nerve network of the intralaminar omasal plexus showed radial and transverse trajectories reflecting the spatial arrangement of the intralaminar musculature. The demonstrated structural complexity of the ENS reflects the functional complexity of the ruminant forestomach and indicates the relatively high degree of autonomy in coordinating the different motility patterns required for the processing of the ingesta.

title: Structural differences of the enteric nervous system in the XXXX forestomach revealed by whole mount immunohistochemistry.

answer: @entity1


abstract: The aim of this study was to compare apneic time with the @entity0 diving response, defined as heart rate (HR) reduction and reduced skin blood flow, in groups with varying degrees of breath-hold diving experience. @entity2 in air and @entity3 with face immersion in cold water were thus recorded in nine groups. Skin capillary blood flow was recorded in six of the groups. All subjects received the same information on maximizing apneic duration, and no information about their progress during the @entity3 . The longest @entity3 and the most pronounced cardiovascular adjustments were found in the young, trained divers. It was found that apneic time was significantly correlated to @entity2 among the nine groups (r = 0.94, P < 0.001), and to skin capillary blood flow reduction among the six groups where the parameter was measured (r = 0.82, P < 0.05). The correlation between @entity2 and skin capillary blood flow reduction was also significant (r = 0.85, P < 0.05). When the difference in @entity2 and apneic time between @entity3 in air and @entity3 with face immersion were compared in the nine groups, it was found that all groups reacted with a more pronounced @entity2 during @entity3 with face immersion. All groups without prior breath-hold diving experience were found to perform shorter @entity3 with face immersion than @entity3 in air, or @entity3 of the same duration in both conditions, which has been reported in other studies. However, in all groups with diving experience, the apneic time was prolonged during @entity3 with face immersion. The results of this study suggest an @entity1 -conserving effect of the diving response in trained apneic divers.

title: Diving response and apneic time in XXXX .

answer: @entity0


abstract: An unexpected association with @entity0 and @entity7 was found during a review of 91 cases of benign and @entity3 . Sixty-three @entity2 were benign, 11 had areas of borderline @entity2 , and 17 had a component of @entity4 . Such @entity2 were divided into glandular/cystic (61 cases) and papillary (30 cases) according to their gross and microscopic appearance. Among the 61 @entity1 with glandular/cystic @entity9 , 13 (21%) had @entity0 and 19 (31%) also had @entity7 . Among the 30 @entity1 with papillary @entity9 there were no cases of @entity0 and only 2 @entity1 had @entity7 . The average age of the @entity1 with @entity3 and @entity0 or @entity7 was higher (66 years) than that of @entity1 without @entity0 or @entity7 (55 years). More @entity1 with @entity0 and @entity7 had bilateral @entity9 than @entity1 without @entity0 or @entity7 . We also reviewed the medical records of 100 @entity1 with @entity3 without @entity9 component, 100 @entity1 with @entity0 , and 100 @entity1 with @entity8 . Six percent of @entity1 with @entity3 had @entity0 and 16% of each one of these groups had @entity7 . This unexpected association found between glandular/cystic @entity9 , @entity0 , and @entity7 might be explained by defects common to these organs. Disorders of some of these organs have been linked by common genetic changes and it is known that these organs are under the influence of similar hormones. Mutations of @entity6 have been found in breast and @entity5 . The thyroid and ovaries are controlled by glycoprotein hormones of the pituitary gland, which have common alpha subunits.

title: The association of benign and @entity3 with XXXX and @entity7 .

answer: @entity0


abstract: An unexpected association with @entity0 and @entity7 was found during a review of 91 cases of benign and @entity3 . Sixty-three @entity2 were benign, 11 had areas of borderline @entity2 , and 17 had a component of @entity4 . Such @entity2 were divided into glandular/cystic (61 cases) and papillary (30 cases) according to their gross and microscopic appearance. Among the 61 @entity1 with glandular/cystic @entity9 , 13 (21%) had @entity0 and 19 (31%) also had @entity7 . Among the 30 @entity1 with papillary @entity9 there were no cases of @entity0 and only 2 @entity1 had @entity7 . The average age of the @entity1 with @entity3 and @entity0 or @entity7 was higher (66 years) than that of @entity1 without @entity0 or @entity7 (55 years). More @entity1 with @entity0 and @entity7 had bilateral @entity9 than @entity1 without @entity0 or @entity7 . We also reviewed the medical records of 100 @entity1 with @entity3 without @entity9 component, 100 @entity1 with @entity0 , and 100 @entity1 with @entity8 . Six percent of @entity1 with @entity3 had @entity0 and 16% of each one of these groups had @entity7 . This unexpected association found between glandular/cystic @entity9 , @entity0 , and @entity7 might be explained by defects common to these organs. Disorders of some of these organs have been linked by common genetic changes and it is known that these organs are under the influence of similar hormones. Mutations of @entity6 have been found in breast and @entity5 . The thyroid and ovaries are controlled by glycoprotein hormones of the pituitary gland, which have common alpha subunits.

title: The association of benign and @entity3 with @entity0 and XXXX .

answer: @entity7


abstract: An unexpected association with @entity0 and @entity7 was found during a review of 91 cases of benign and @entity3 . Sixty-three @entity2 were benign, 11 had areas of borderline @entity2 , and 17 had a component of @entity4 . Such @entity2 were divided into glandular/cystic (61 cases) and papillary (30 cases) according to their gross and microscopic appearance. Among the 61 @entity1 with glandular/cystic @entity9 , 13 (21%) had @entity0 and 19 (31%) also had @entity7 . Among the 30 @entity1 with papillary @entity9 there were no cases of @entity0 and only 2 @entity1 had @entity7 . The average age of the @entity1 with @entity3 and @entity0 or @entity7 was higher (66 years) than that of @entity1 without @entity0 or @entity7 (55 years). More @entity1 with @entity0 and @entity7 had bilateral @entity9 than @entity1 without @entity0 or @entity7 . We also reviewed the medical records of 100 @entity1 with @entity3 without @entity9 component, 100 @entity1 with @entity0 , and 100 @entity1 with @entity8 . Six percent of @entity1 with @entity3 had @entity0 and 16% of each one of these groups had @entity7 . This unexpected association found between glandular/cystic @entity9 , @entity0 , and @entity7 might be explained by defects common to these organs. Disorders of some of these organs have been linked by common genetic changes and it is known that these organs are under the influence of similar hormones. Mutations of @entity6 have been found in breast and @entity5 . The thyroid and ovaries are controlled by glycoprotein hormones of the pituitary gland, which have common alpha subunits.

title: The association of benign and XXXX with @entity0 and @entity7 .

answer: @entity3


abstract: INTRODUCTION: Monoclonal @entity4 antibodies are a new treatment of severe @entity3 . One of the possible side effects is the appearance of @entity6 . We report here on three cases of disseminated @entity5 observed in @entity0 undergoing treatment with infliximab. EXEGESIS: A 45-year-old @entity0 , treated with infliximab, was hospitalised after five infusions for @entity2 and dyspnoea. The exams showed @entity7 . The second case is a 75-year-old @entity0 whose symptoms were @entity2 , cough and cervical adenopathy after three infliximab infusions. Diagnosis was disseminated @entity5 . The third case is a 59-year-old @entity0 who was hospitalised for an @entity1 with dyspnoea, after two infliximab infusions. We discovered @entity7 . CONCLUSION: These three cases added to the 68 cases of @entity5 registered with the treatment of infliximab. This confirms the risk of severe opportunist infectious side effects. @entity4 is a cytokine which has anti-infectious properties. These @entity5 are severe and generalized. It is recommended to search for an active or @entity8 before beginning treatment with infliximab, and to check these @entity0 frequently.

title: [Anti- @entity4 monoclonal antibodies (infliximab) and XXXX : apropos of 3 cases].

answer: @entity5


abstract: INTRODUCTION: Monoclonal @entity4 antibodies are a new treatment of severe @entity3 . One of the possible side effects is the appearance of @entity6 . We report here on three cases of disseminated @entity5 observed in @entity0 undergoing treatment with infliximab. EXEGESIS: A 45-year-old @entity0 , treated with infliximab, was hospitalised after five infusions for @entity2 and dyspnoea. The exams showed @entity7 . The second case is a 75-year-old @entity0 whose symptoms were @entity2 , cough and cervical adenopathy after three infliximab infusions. Diagnosis was disseminated @entity5 . The third case is a 59-year-old @entity0 who was hospitalised for an @entity1 with dyspnoea, after two infliximab infusions. We discovered @entity7 . CONCLUSION: These three cases added to the 68 cases of @entity5 registered with the treatment of infliximab. This confirms the risk of severe opportunist infectious side effects. @entity4 is a cytokine which has anti-infectious properties. These @entity5 are severe and generalized. It is recommended to search for an active or @entity8 before beginning treatment with infliximab, and to check these @entity0 frequently.

title: [Anti- XXXX monoclonal antibodies (infliximab) and @entity5 : apropos of 3 cases].

answer: @entity4


abstract: Interruption of lactation provokes a massive @entity1 in the @entity0 pituitary gland. This process was determined to be non-apoptotic in nature, and this observation raised many questions as cell death by apoptosis has been described in several tissues after withdrawal of trophic hormones. In this study we explored various experimental conditions and gathered new information leading to a comprehensive interpretation of the factors involved in the induction of apoptosis in lactotrophs. With this aim, we investigated the apoptogenic role of @entity4 on lactotrophs in several experimental models involving male and female @entity0 . Even though @entity4 increased the expression of @entity5 in all experimental models, apoptosis was only triggered in male and ovariectomised females. In both conditions the @entity3 stimulation is low or nil, and the occurrence of apoptosis can be correlated with the appearance of atypical lactotrophs and the level of @entity5 expression. The existence of apoptosis was validated with the observation of DNA laddering in electrophoresis. By contrast, in intact females the majority of lactotrophs present signs of an increased prolactin secretion and no DNA fragmentation was found. Endogenous @entity3 probably prevent the deep inhibitory effect of a @entity2 agonist and thus block apoptosis. Besides, the morphological analysis of regressing pituitary revealed the coexistence of lactotrophs to be an important factor responsible for tissue remodelling in functional pituitary glands undergoing apoptotic and non-apoptotic cell deaths. The non-apoptotic cell death appeared to be an important factor responsible for tissue remodelling in functional pituitary glands. The present results suggest that the occurrence of apoptosis in regressing lactotrophs caused by @entity4 is sexually dimorphic and probably associated with the survival effect of endogenous @entity3 in intact females.

title: Sexual dimorphism of apoptosis in lactotrophs induced by XXXX .

answer: @entity4


abstract: PURPOSE: Prospective evaluation of the efficacy and safety of subconjunctival @entity6 injections for resistant, nonnecrotizing, @entity9 . DESIGN: Prospective, noncomparative, interventional case series. @entity0 : Twelve eyes of 10 consecutive @entity0 seen in the Doheny Eye Institute between August 1999 and December 2000 with diffuse, nonnecrotizing @entity9 that was resistant to systemic antiinflammatory therapy. Eyes with a history of @entity3 response were excluded. INTERVENTION: Subconjunctival injection of @entity8 to the areas of maximal @entity1 . MAIN OUTCOME MEASURES: @entity9 activity, adverse treatment effects, and number of systemic medications required at the end of the follow-up period. RESULTS: Within 1 to 14 days after injection, complete resolution of signs and symptoms was achieved in 11 eyes and partial resolution in 1 eye. Two @entity0 had one recurrence each, 2.5 and 11 months after injection. Six of 10 @entity0 were able to discontinue all systemic therapy ( @entity4 +/- immunosuppressive drugs); the remaining 4 needed continued oral therapy for systemic indications. Transient @entity7 and @entity5 occurred in one eye each. Median follow-up period was 15 months. No eye developed @entity2 . CONCLUSIONS: Subconjunctival injection of @entity8 is a safe and effective treatment for resistant, nonnecrotizing @entity9 . It provides rapid effect, is well tolerated, and may spare @entity0 the significant complications and side effects of systemic corticosteroid and immunosuppressive therapy.

title: A prospective evaluation of subconjunctival injection of XXXX for resistant @entity9 .

answer: @entity8


abstract: PURPOSE: Prospective evaluation of the efficacy and safety of subconjunctival @entity6 injections for resistant, nonnecrotizing, @entity9 . DESIGN: Prospective, noncomparative, interventional case series. @entity0 : Twelve eyes of 10 consecutive @entity0 seen in the Doheny Eye Institute between August 1999 and December 2000 with diffuse, nonnecrotizing @entity9 that was resistant to systemic antiinflammatory therapy. Eyes with a history of @entity3 response were excluded. INTERVENTION: Subconjunctival injection of @entity8 to the areas of maximal @entity1 . MAIN OUTCOME MEASURES: @entity9 activity, adverse treatment effects, and number of systemic medications required at the end of the follow-up period. RESULTS: Within 1 to 14 days after injection, complete resolution of signs and symptoms was achieved in 11 eyes and partial resolution in 1 eye. Two @entity0 had one recurrence each, 2.5 and 11 months after injection. Six of 10 @entity0 were able to discontinue all systemic therapy ( @entity4 +/- immunosuppressive drugs); the remaining 4 needed continued oral therapy for systemic indications. Transient @entity7 and @entity5 occurred in one eye each. Median follow-up period was 15 months. No eye developed @entity2 . CONCLUSIONS: Subconjunctival injection of @entity8 is a safe and effective treatment for resistant, nonnecrotizing @entity9 . It provides rapid effect, is well tolerated, and may spare @entity0 the significant complications and side effects of systemic corticosteroid and immunosuppressive therapy.

title: A prospective evaluation of subconjunctival injection of @entity8 for resistant XXXX .

answer: @entity9


abstract: BACKGROUND: @entity6 is a mitochondrial membrane transporter that is postulated to uncouple oxidative phosphorylation from @entity3 synthesis producing heat instead of @entity3 . @entity0 @entity6 is mainly expressed in skeletal muscle, which plays an important role in energy homeostasis and substrate oxidation. Therefore, @entity6 is a good candidate gene for @entity1 . MATERIALS AND METHODS: We analyzed, among 734 subjects from the Qu  bec Family Study, a new GA repeat microsatellite located in intervening sequence (IVS) 6 (GAIVS6) in @entity6 gene, and two already described restriction fragment length polymorphisms (RFLP) @entity7 ( @entity4 ) and @entity8 ( @entity5 ). Covariance analysis across genotypes for different adiposity, resting energy expenditure, and @entity2 metabolism variables was undertaken with age and sex, plus body fat and body mass for nonadiposity phenotypes, as covariates. RESULTS: We found strong associations between GAIVS6 and body mass index (p = 0.0001), fat mass (p = 0.0005), percentage body fat (p = 0.0004), the sum of six skinfold thickness (p = 0.0001), and leptin level (p = 0.0001). Homozygote for the GAIVS6 240 bp alleles (15% frequency in QFS) showed higher adiposity than subjects with the GAIVS6 238 bp allele (70% in QFS). The exons, the 5' untranslated region (UTR), and the exon-intron junctions of @entity6 gene from subjects homozygote for either GAIVS6 238 bp or 240 bp alleles were sequenced in search for mutations. Variants 5'UTR @entity9 and @entity7 ( @entity4 ) were detected, whereas @entity10 was uncovered, but no new exonic or splice junction mutation was observed. RFLP @entity7 ( @entity4 ) was not associated to adiposity in QFS; @entity11 showed no variation. CONCLUSION: Our results suggest that some alleles of @entity6 are involved in the etiology of @entity0 @entity1 .

title: Association between uncoupling protein 3 gene and XXXX -related phenotypes in the Qu  bec Family Study.

answer: @entity1


abstract: OBJECTIVE: To assess the implications of positive cytology for malignant cells (positive results) from peritoneal washings in the management of @entity0 with @entity2 . DESIGN: Retrospective cohort study. SETTING: Referral practice in a university hospital. @entity0 : A total of 32 consecutive @entity2 @entity0 with positive results from peritoneal washings during a 4-year period, 17 with visible biopsy-proven intraabdominal @entity1 at the time of laparoscopy or laparotomy and 15 without visible @entity1 . A treatment-matched control group of 30 @entity0 was randomly selected from a group of 105 @entity0 with negative cytology for malignant cells (negative results) from peritoneal-fluid cytology. INTERVENTIONS: Eight of 17 @entity0 with visible @entity1 underwent treatment with chemotherapy, radiation, or both; 13 of the 15 @entity0 with no visible @entity1 underwent further treatment, including pancreatic resection in 2 @entity0 and external beam radiation in 13 @entity0 (3 with intraoperative radiation therapy). MAIN OUTCOME MEASURES: Time to @entity1 and mortality. RESULTS: Median survival among @entity0 with and without visible @entity1 was 7.8 months and 8.6 months, respectively (P=.95), despite the fact that @entity0 without visible @entity1 received more treatment. @entity0 without visible @entity1 at presentation were found to have metastatic disease as documented by computed tomographic scan or subsequent laparotomy at a median time of 2.9 months. The survival of treatment-matched @entity0 with negative cytology was significantly longer (median, 13.5 months; P=.04). CONCLUSIONS: @entity2 @entity0 with peritoneal micrometastases have a dismal outcome even without macroscopic @entity1 . Since these @entity0 do not benefit from local therapy, the finding of a positive result from peritoneal-fluid cytologic testing contraindicates further irradiation or surgery, except for specific complications.

title: Implications of peritoneal cytology for XXXX management.

answer: @entity2


abstract: OBJECTIVE: To evaluate the effect of unilateral thalamotomy in @entity0 with @entity1 . METHODS: The junction of the ventralis oralis posterior and ventralis intermedius nuclei targeted under CT-guidance, and confirmed by impedance recording and macrostimulation. RESULTS: At the 6-month assessment the @entity2 has been completely abolished in 37 @entity0 (82.2%), and reduced in 6 @entity0 (13.3%). The Unified @entity1 Rating Scale @entity2 score decreased by 92.5%, @entity3 improved by 65.9%. Axial symptoms and @entity4 showed smaller improvement. The levodopa and anti-cholinergic medication significantly reduced. An improvement in the quality of life measured by the @entity1 Questionnaire (PDQ-39) has been observed. The dimensions of mobility, activities of daily living, emotional well being, and stigma were significantly (P<0.05) better, other changes were not significant. The single index improved from 47.8+/-7.8 to 28.9+/-6.3. Transient complications noted in 9 @entity0 (20%), mild persistent morbidity observed in 3 @entity0 (6.7%). At the 1, 2 and 3-year follow-up neither contralateral @entity2 , @entity3 , nor @entity4 progression was statistically significant. CONCLUSIONS: CT-guided thalamotomy with macro-electrode mapping provides a safe, effective and long lasting control of @entity2 and @entity3 , reduces the need for medication, and improves the quality of life.

title: CT-guided unilateral thalamotomy with macroelectrode mapping for the treatment of XXXX .

answer: @entity1


abstract: The influence of @entity3 ( @entity3 ) volume on common fetal lung maturity (FLM) indices was evaluated. Cases diagnosed with altered @entity3 volume as estimated by ultrasound (n = 71; @entity1 = 33, @entity0 = 38) were matched to controls by: gestational age (GA) at amniocentesis, GA at delivery, neonatal weight, sex, and pregnancy complication. FLM was assessed on @entity3 specimens obtained by transabdominal amniocentesis by planimetric and stechiometric L/S, @entity2 (PG), and lamellar bodies counts (LB). In cases with @entity1 , L/S ratios (planimetric and stechiometric) were statistically lower in cases with respect to controls (2.1 +/- 0.9 vs. 2.8 +/- 1.0, p = 0.007, and 4.8 +/- 2.4 vs. 5.9 +/- 2.7, p < 0.04; respectively). Absence of PG was more frequent in (70.8% vs. 50%, p = 0.02). LB counts were lower in cases than in controls (15.5 +/- 12.1 x 10(3)/microL vs. 21.9 +/- 14.3 x 10(3)/microL, p < 0.05). In cases with @entity0 , no difference was found for planimetric and stechiometric L/S in comparison to controls (2.6 +/- 1.2 vs. 2.6 +/- 1.0, N.S. and 4.9 +/- 2.1 vs. 4.6 +/- 1.8, N.S.; respectively), absence of PG (62.5% vs. 50%, N.S.), and LB counts (27.2 x 10(3)/microL +/- 12.8 x 10(3)/microL vs. 28.6 x 10(3)/microL +/- 24.1 x 10(3)/microL, N.S.). In conclusion, @entity0 was not associated with altered FLM indices; in cases with @entity1 all FLM indices were significantly lower.

title: The effect of XXXX and @entity0 on fetal lung maturity indexes.

answer: @entity1


abstract: The influence of @entity3 ( @entity3 ) volume on common fetal lung maturity (FLM) indices was evaluated. Cases diagnosed with altered @entity3 volume as estimated by ultrasound (n = 71; @entity1 = 33, @entity0 = 38) were matched to controls by: gestational age (GA) at amniocentesis, GA at delivery, neonatal weight, sex, and pregnancy complication. FLM was assessed on @entity3 specimens obtained by transabdominal amniocentesis by planimetric and stechiometric L/S, @entity2 (PG), and lamellar bodies counts (LB). In cases with @entity1 , L/S ratios (planimetric and stechiometric) were statistically lower in cases with respect to controls (2.1 +/- 0.9 vs. 2.8 +/- 1.0, p = 0.007, and 4.8 +/- 2.4 vs. 5.9 +/- 2.7, p < 0.04; respectively). Absence of PG was more frequent in (70.8% vs. 50%, p = 0.02). LB counts were lower in cases than in controls (15.5 +/- 12.1 x 10(3)/microL vs. 21.9 +/- 14.3 x 10(3)/microL, p < 0.05). In cases with @entity0 , no difference was found for planimetric and stechiometric L/S in comparison to controls (2.6 +/- 1.2 vs. 2.6 +/- 1.0, N.S. and 4.9 +/- 2.1 vs. 4.6 +/- 1.8, N.S.; respectively), absence of PG (62.5% vs. 50%, N.S.), and LB counts (27.2 x 10(3)/microL +/- 12.8 x 10(3)/microL vs. 28.6 x 10(3)/microL +/- 24.1 x 10(3)/microL, N.S.). In conclusion, @entity0 was not associated with altered FLM indices; in cases with @entity1 all FLM indices were significantly lower.

title: The effect of @entity1 and XXXX on fetal lung maturity indexes.

answer: @entity0


abstract: @entity0 with @entity2 -resistant @entity13 often have an unsatisfactory long-term outcome and are at risk of developing @entity3 . We prospectively treated 65 @entity0 with idiopathic @entity2 -resistant @entity13 and @entity8 ( @entity8 ) with intravenous pulses of @entity5 and oral @entity10 . @entity7 (5 mg/kg) or @entity12 (30 mg/kg) was administered intravenously, initially 6 pulses on alternate days, followed by 4 fortnightly and 8 monthly pulses. Oral @entity10 therapy was given for 12 weeks and tapering doses of @entity6 were administered for 52 weeks. The mean age at treatment was 85.7+/- 44.9 months. Five @entity0 developed serious @entity4 during administration of initial alternate-day pulses and were excluded. Of 59 @entity0 who completed initial alternate-day therapy, 17 had complete and 8 partial remission; 34 (57.6%) @entity0 did not respond to treatment. The median urine protein to @entity11 ratio decreased from 10.0 to 0.75 (P<0.005) and serum @entity14 increased from 1.9 g/dl to 2.4 g/dl (P<0.01). The median duration of follow-up after stopping pulse therapy was 25.6 months. Thirty-four @entity0 were followed for more than 3 years (median 4.5 years). Of these, 22 (64.7%) @entity0 had a favorable outcome; persistent complete remission was seen in 15 @entity0 and @entity2 -responsive relapses in 7. Seven @entity0 had non- @entity13 -range @entity9 , 2 had @entity13 -range @entity9 , and 3 (8.8%) were in @entity3 . There was no significant difference in the short- and long-term outcome of @entity0 with initial (n=28) and late resistance (n=31). The outcome in @entity0 receiving intravenous @entity7 (n=48) or @entity12 (n=11) was also similar. The chief side effects included worsening of height standard deviation score (47.4%), transient @entity1 (42.5%), and serious @entity4 (18.5%). We conclude that prolonged treatment with intravenous @entity5 and oral @entity10 is beneficial in @entity0 with @entity2 -resistant @entity8 . Expensive protocols can be successfully modified and used, depending upon the availability of health resources.

title: Treatment of XXXX with pulse steroids and oral @entity10 .

answer: @entity8


abstract: @entity0 with @entity2 -resistant @entity13 often have an unsatisfactory long-term outcome and are at risk of developing @entity3 . We prospectively treated 65 @entity0 with idiopathic @entity2 -resistant @entity13 and @entity8 ( @entity8 ) with intravenous pulses of @entity5 and oral @entity10 . @entity7 (5 mg/kg) or @entity12 (30 mg/kg) was administered intravenously, initially 6 pulses on alternate days, followed by 4 fortnightly and 8 monthly pulses. Oral @entity10 therapy was given for 12 weeks and tapering doses of @entity6 were administered for 52 weeks. The mean age at treatment was 85.7+/- 44.9 months. Five @entity0 developed serious @entity4 during administration of initial alternate-day pulses and were excluded. Of 59 @entity0 who completed initial alternate-day therapy, 17 had complete and 8 partial remission; 34 (57.6%) @entity0 did not respond to treatment. The median urine protein to @entity11 ratio decreased from 10.0 to 0.75 (P<0.005) and serum @entity14 increased from 1.9 g/dl to 2.4 g/dl (P<0.01). The median duration of follow-up after stopping pulse therapy was 25.6 months. Thirty-four @entity0 were followed for more than 3 years (median 4.5 years). Of these, 22 (64.7%) @entity0 had a favorable outcome; persistent complete remission was seen in 15 @entity0 and @entity2 -responsive relapses in 7. Seven @entity0 had non- @entity13 -range @entity9 , 2 had @entity13 -range @entity9 , and 3 (8.8%) were in @entity3 . There was no significant difference in the short- and long-term outcome of @entity0 with initial (n=28) and late resistance (n=31). The outcome in @entity0 receiving intravenous @entity7 (n=48) or @entity12 (n=11) was also similar. The chief side effects included worsening of height standard deviation score (47.4%), transient @entity1 (42.5%), and serious @entity4 (18.5%). We conclude that prolonged treatment with intravenous @entity5 and oral @entity10 is beneficial in @entity0 with @entity2 -resistant @entity8 . Expensive protocols can be successfully modified and used, depending upon the availability of health resources.

title: Treatment of @entity8 with pulse steroids and oral XXXX .

answer: @entity10


abstract: To study the role of @entity2 in lysosomal protein transport, we engineered two novel glycosylation signals ( @entity3 -X-Ser/Thr) into the cDNA of @entity0 procathepsin L, a lysosomal acid protease. We constructed six mutant cDNAs encoding glycosylation signals at mutant sites @entity3 -138, @entity3 -175, or both sites together, in the presence or absence of the wild-type @entity3 -204 site. We stably transfected wild-type and mutant cDNAs into NIH3T3 @entity1 fibroblasts and then used species-specific antibodies to determine the glycosylation status, phosphorylation, localization, and transport kinetics of recombinant @entity0 procathepsin L containing one, two, or three glycosylation sites. Both novel glycosylation sites were capable of being glycosylated, although @entity3 -175 was utilized only 30-50% of the time. Like the wild-type glycosylation at @entity3 -204, @entity4 at @entity3 -138 and @entity3 -175 were completely sensitive to endoglycosidase H, and they were phosphorylated. Mutant proteins containing two @entity4 were capable of being delivered to lysosomes, but there was not a consistent relationship between the efficiency of lysosomal delivery and @entity2 content of the protein. Pulse-chase labeling revealed a unique biosynthetic pattern for proteins carrying the @entity3 -175 glycosylation sequence. Whereas wild-type procathepsin L and mutants bearing @entity2 at @entity3 -138 appeared in lysosomes by about 60 min, proteins with @entity2 at @entity3 -175 were processed to a lysosome-like polypeptide within 15 min. Temperature shift, @entity7 , and @entity6 experiments suggested that the rapid processing did not occur in the endoplasmic reticulum and that @entity3 -175 mutants could interact with the @entity5 receptor. Taken together, our results are consistent with the interpretation that @entity3 -175 @entity2 confers rapid transport to lysosomes. We may have identified a recognition domain in procathepsin L that is important for its interactions with the cellular transport machinery.

title: Effect of XXXX position on lysosomal transport of procathepsin L.

answer: @entity2


abstract: OBJECTIVE: The aim of our study was to evaluate the frequency of skin manifestations, including the @entity1 , in young @entity2 @entity0 . In addition, we studied the relation of the cutaneous manifestations to @entity1 duration, glycemic control, and microvascular complications. RESEARCH DESIGN AND METHODS: The frequency of skin manifestations, including the @entity1 , were examined in 238 @entity2 @entity0 (disease duration > 5 years) and 122 healthy control subjects in a cross-sectional study. In addition, we studied the relation of the cutaneous manifestations with @entity1 duration, glycemic control, BMI, microvascular complications, and stratum corneum hydration using a stepwise logistic regression. RESULTS: @entity1 skin manifestations were detected in 168 of 238 (71%) @entity2 @entity0 and in 18 of 122 (14%) of the control subjects. Ichthyosiform skin changes of the shins, @entity5 -like skin changes, @entity7 , and @entity3 were detected in 48 vs. 7%, 39 vs. 0%, 32 vs. 7%, and 21 vs. 0.8% of the @entity0 and control subjects, respectively. In the @entity1 @entity0 , a significant association was found between @entity6 of the shins and @entity5 -like skin changes of the hand (P < 0.001) and between @entity5 -like skin changes and the skin dryness of the palms (P < 0.0001). When @entity1 risk factors were considered, @entity1 duration was significantly associated with @entity5 -like skin changes and @entity6 of the shins (P < 0.0001). The latter was also found to be related to @entity1 (P < 0.0001). @entity8 was present in 21% of the @entity0 versus 9% in control subjects and was found to be exclusively associated with high BMI. CONCLUSIONS: Acquired @entity6 is a common finding and the most prevalent skin manifestation in young @entity2 @entity0 . The development of several skin manifestations in insulin-dependent @entity0 seems to be related to duration of @entity1 and to development of @entity4 .

title: The prevalence of cutaneous manifestations in XXXX @entity0 and their association with @entity4 .

answer: @entity2


abstract: OBJECTIVE: The aim of our study was to evaluate the frequency of skin manifestations, including the @entity1 , in young @entity2 @entity0 . In addition, we studied the relation of the cutaneous manifestations to @entity1 duration, glycemic control, and microvascular complications. RESEARCH DESIGN AND METHODS: The frequency of skin manifestations, including the @entity1 , were examined in 238 @entity2 @entity0 (disease duration > 5 years) and 122 healthy control subjects in a cross-sectional study. In addition, we studied the relation of the cutaneous manifestations with @entity1 duration, glycemic control, BMI, microvascular complications, and stratum corneum hydration using a stepwise logistic regression. RESULTS: @entity1 skin manifestations were detected in 168 of 238 (71%) @entity2 @entity0 and in 18 of 122 (14%) of the control subjects. Ichthyosiform skin changes of the shins, @entity5 -like skin changes, @entity7 , and @entity3 were detected in 48 vs. 7%, 39 vs. 0%, 32 vs. 7%, and 21 vs. 0.8% of the @entity0 and control subjects, respectively. In the @entity1 @entity0 , a significant association was found between @entity6 of the shins and @entity5 -like skin changes of the hand (P < 0.001) and between @entity5 -like skin changes and the skin dryness of the palms (P < 0.0001). When @entity1 risk factors were considered, @entity1 duration was significantly associated with @entity5 -like skin changes and @entity6 of the shins (P < 0.0001). The latter was also found to be related to @entity1 (P < 0.0001). @entity8 was present in 21% of the @entity0 versus 9% in control subjects and was found to be exclusively associated with high BMI. CONCLUSIONS: Acquired @entity6 is a common finding and the most prevalent skin manifestation in young @entity2 @entity0 . The development of several skin manifestations in insulin-dependent @entity0 seems to be related to duration of @entity1 and to development of @entity4 .

title: The prevalence of cutaneous manifestations in @entity2 @entity0 and their association with XXXX .

answer: @entity4


abstract: OBJECTIVE: The aim of our study was to evaluate the frequency of skin manifestations, including the @entity1 , in young @entity2 @entity0 . In addition, we studied the relation of the cutaneous manifestations to @entity1 duration, glycemic control, and microvascular complications. RESEARCH DESIGN AND METHODS: The frequency of skin manifestations, including the @entity1 , were examined in 238 @entity2 @entity0 (disease duration > 5 years) and 122 healthy control subjects in a cross-sectional study. In addition, we studied the relation of the cutaneous manifestations with @entity1 duration, glycemic control, BMI, microvascular complications, and stratum corneum hydration using a stepwise logistic regression. RESULTS: @entity1 skin manifestations were detected in 168 of 238 (71%) @entity2 @entity0 and in 18 of 122 (14%) of the control subjects. Ichthyosiform skin changes of the shins, @entity5 -like skin changes, @entity7 , and @entity3 were detected in 48 vs. 7%, 39 vs. 0%, 32 vs. 7%, and 21 vs. 0.8% of the @entity0 and control subjects, respectively. In the @entity1 @entity0 , a significant association was found between @entity6 of the shins and @entity5 -like skin changes of the hand (P < 0.001) and between @entity5 -like skin changes and the skin dryness of the palms (P < 0.0001). When @entity1 risk factors were considered, @entity1 duration was significantly associated with @entity5 -like skin changes and @entity6 of the shins (P < 0.0001). The latter was also found to be related to @entity1 (P < 0.0001). @entity8 was present in 21% of the @entity0 versus 9% in control subjects and was found to be exclusively associated with high BMI. CONCLUSIONS: Acquired @entity6 is a common finding and the most prevalent skin manifestation in young @entity2 @entity0 . The development of several skin manifestations in insulin-dependent @entity0 seems to be related to duration of @entity1 and to development of @entity4 .

title: The prevalence of cutaneous manifestations in @entity2 XXXX and their association with @entity4 .

answer: @entity0


abstract: OBJECTIVES: To evaluate the effects of endogenous @entity2 and @entity7 on the IGF-system during the normal menstrual cycle in healthy premenopausal @entity0 not using contraceptive drugs. METHODS: Nine @entity0 had fasting blood samples obtained at 2-3 days intervals during a 5 week study period. Plasma levels of @entity3 , @entity6 , IGFBP-I, @entity5 , @entity1 and @entity4 were measured by radioimmunoassay (RIA) in each sample. @entity5 was also evaluated by Western ligand blot (WLB) and immunoblot. Any differences between the menstrual phase (defined as day 1-5), follicular and luteal phases (separation based on plasma @entity1 and @entity4 values) were evaluated by the Friedman test. RESULTS: A small but significant difference in plasma levels of @entity3 (P < 0.01) and IGFBP-d (P < 0.05) measured by RIA between the three phases were seen with the highest levels found during the follicular phase. No change in plasma levels of @entity8 and @entity6 was found and immunoblots did not reveal any alteration in the ratio of fragmented to intact @entity5 during the menstrual cycle. A positive correlation between plasma levels of @entity3 and @entity1 was seen in 8 out of 9 @entity0 (P = 0.012). CONCLUSIONS: The finding of a slight but significant higher level of plasma @entity3 in the follicular and luteal phases compared with the menstrual phase suggests plasma @entity1 may influence the level of this growth factor. This hypothesis is further supported by the finding of a correlation between plasma levels of @entity3 and @entity1 but not @entity4 in individual @entity0 at different times during the menstrual cycle.

title: Alterations in the insulin-like growth factor system during the menstrual cycle in normal XXXX .

answer: @entity0


abstract: BACKGROUND: Allogeneic bone marrow donors can be incompatible at different levels. Even HLA-identical pairs will be still incompatible for numerous minor histocompatibility antigens (mHag). Nevertheless, some incompatibilities are found to be associated with an increased risk of @entity1 ( @entity1 ), which could be related to the way the immune system recognizes these antigens. METHODS: We determined the specificity of cytotoxic T-cell clones isolated during acute @entity1 or during bone marrow graft rejection in @entity0 (n=14) transplanted with marrow from donors who were histoincompatible for different minor and/or major histocompatibility antigens. RESULTS: We found a clear hierarchy among the different types of histoincompatibilities. In three combinations mismatched for a class I allele, all 27 clones isolated during @entity1 were specific for the incompatible HLA molecule. In the 11 class I-identical combinations, 14 different mHags were recognized. The mHag HA-1, known to have a significant impact on the development of @entity1 , was recognized in the two HA-1-incompatible combinations. In one of these combinations, which was sex mismatched, all 56 clones analyzed were directed against HA-1, demonstrating the dominance of this mHag. In the four HA-1-compatible, sex-mismatched combinations, the anti-H-Y response was directed against one immunodominant epitope rather than against multiple Y-chromosome-encoded epitopes. All male specific cytotoxic T lymphocytes (n=15) recognized the same high-performance liquid chromatography-purified peptide fraction presented by T2 cells. Moreover, all cytotoxic T lymphocytes tested (n=6) were specific for the @entity2 -derived peptide FIDSYICQV, originally described as being the H-Y epitope recognized in the context of HLA-A*0201. CONCLUSIONS: Some histocompatibility antigens are recognized in an immunodominant fashion and will therefore be recognized in the majority of mismatched combinations. Only for such antigens, correlations between mismatches and the occurrence of @entity1 or graft rejections will be found.

title: HA-1 and the XXXX -derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation.

answer: @entity2


abstract: The objective of the study contained herein was to evaluate the clinical use of the Berg Balance Scale in a heterogeneous acute inpatient rehabilitation population and to assess the relationship between balance scores at admission and rehabilitation outcomes, including functional gain and length of stay. This was a prospective study of 45 @entity0 with diagnoses including @entity1 (n = 15), @entity2 (n = 19), and other impairments (n = 11) who were admitted for acute inpatient rehabilitation. Functional ability was evaluated with the Functional Independence Measure (FIM) instrument, and balance was measured using the 14-item Berg Balance Scale. These measures were assessed both at admission to and discharge from inpatient rehabilitation. Correlation and multiple regression analyses were used to determine the relationship between balance and functional ability scores at admission and rehabilitation outcomes at discharge, including length of stay, functional gain, and efficiency. Analyses of variance comparing impairment groups indicated that @entity0 with @entity2 were younger than the @entity1 and other groups, but there were no group differences on FIM or balance scores at admission or discharge. There were no significant group differences for any of the outcome measures. When the impairment groups were collapsed into a single heterogeneous group, multiple regression analyses demonstrated that the sitting unsupported item score at admission accounted for 27% of the variation in length of stay, once demographic influences were controlled. The FIM efficiency score was predicted best by the total Berg Balance Scale score, with 22% of the variance accounted for. In contrast, balance scores did not provide predictive information about the FIM gain score beyond that already provided by the FIM-Total score at admission, which accounted for 10% of the variance once demographics were controlled. Balance scores collected at admission to inpatient rehabilitation, in whole and in part, were shown to account for moderate amounts of variation in length of stay and the FIM efficiency score. For several of the rehabilitation outcomes, balance scores at admission accounted for more variation than scores on the FIM instrument. These findings suggest that routine assessment of balance at admission to inpatient rehabilitation may enhance the ability to predict rehabilitation outcomes beyond that provided by assessment of functional status alone.

title: Admission balance and outcomes of XXXX admitted for acute inpatient rehabilitation.

answer: @entity0


abstract: 1. Three experiments were performed to assess the effects of decreasing protein concentration in the finishing diets for growing @entity8 (8 to 12 weeks of age) by adding 4 essential @entity2 ( @entity7 , @entity0 , @entity4 , @entity5 and @entity6 ). Experimental diets with @entity1 ( @entity1 ) contents from 105 to 142 g/kg, were compared with control diets providing 150 to 160 g/kg @entity1 . In each trial, all diets were isocaloric. No significant modification in growth or carcase quality was observed when @entity1 was greater than 124 g/kg in diets supplemented with the 4 essential @entity7 . 2. There was no advantages in supplying more than 4.3 g of digestible @entity0 per kg of diet (12.75 MJ ME/kg). When @entity5 was not added, breast yield decreased significantly (-4.3%), while omitting @entity6 supplementation did not influence performance. 3. Furthermore, the experiments confirmed that reducing @entity1 had little or no effect on food conversion efficiency and fatness in @entity8 ducklings, unlike the observed situation in broiler @entity3 .

title: Use of industrial XXXX to allow low protein concentrations in finishing diets for growing @entity8 .

answer: @entity2


abstract: 1. Three experiments were performed to assess the effects of decreasing protein concentration in the finishing diets for growing @entity8 (8 to 12 weeks of age) by adding 4 essential @entity2 ( @entity7 , @entity0 , @entity4 , @entity5 and @entity6 ). Experimental diets with @entity1 ( @entity1 ) contents from 105 to 142 g/kg, were compared with control diets providing 150 to 160 g/kg @entity1 . In each trial, all diets were isocaloric. No significant modification in growth or carcase quality was observed when @entity1 was greater than 124 g/kg in diets supplemented with the 4 essential @entity7 . 2. There was no advantages in supplying more than 4.3 g of digestible @entity0 per kg of diet (12.75 MJ ME/kg). When @entity5 was not added, breast yield decreased significantly (-4.3%), while omitting @entity6 supplementation did not influence performance. 3. Furthermore, the experiments confirmed that reducing @entity1 had little or no effect on food conversion efficiency and fatness in @entity8 ducklings, unlike the observed situation in broiler @entity3 .

title: Use of industrial @entity2 to allow low protein concentrations in finishing diets for growing XXXX .

answer: @entity8


abstract: This is a retrospective study analysing 5264 @entity0 treated in the burn centre at G  lhane Military Medical Academy from 1 January 1986 to 31 December 1995. Our burn centre is not only the first, but one of the best established and supported in @entity2 . Our present study has the largest @entity0 group of other previously published studies from @entity2 . Of the total @entity0 studied, 4464 @entity0 had minor burns and were treated on an outpatient basis and 800 @entity0 had moderate to major burns. Although our centre is in a military area in Ankara, only 1047 (20 per cent) @entity0 were military personnel and the military-related burn causes comprised only 6 per cent of the total. The remaining 4217 (80 per cent of the total @entity0 ) were civilians. @entity1 were also more frequent in military @entity0 than civilians. Minor burns were most common in the age group 0-10 years old (40 per cent) and moderate to major burns in the age group 21-30 years (54 per cent). Scalds were the main cause of paediatric burns. Male @entity0 were dominant. The overall mortality among inpatients was 18.2 per cent and mean total body surface area (TBSA) was 57.6 per cent in @entity0 who died. 134 @entity0 demonstrated @entity1 and 82 per cent of these @entity0 died. The epidemiological pattern of our @entity0 is similar to that in other studies from developed countries, although some ethnic causative factors could be found. Our study indicates that emergency measures should be taken to prevent @entity1 at military barracks and industrial workplaces and scalding accidents to @entity0 at home and throughout the country.

title: The last 10 years in a burn centre in Ankara, XXXX : an analysis of 5264 cases.

answer: @entity2


abstract: AIMS: To detail the clinical and angiographic profile, and long-term outcome in consecutive @entity0 with @entity4 of the left anterior descending coronary artery undergoing bypass surgery. METHODS: A retrospective study of all @entity0 (n = 301) (January 1984-December 1990) and undergoing coronary artery bypass grafting for isolated left anterior descending disease, in the Irish Republic, was performed. Survival was compared with that of an exact age- and gender-matched cohort. RESULTS: Mean age was 53 (+/- 9.3) years. There were 238 (79%) males. In 241 (80%) @entity0 an internal thoracic arterial bypass graft was used. Operative mortality was 1.3%. Of the 280 (93%) @entity0 alive (16 @entity1 ) at 7.1 (+/- 1.9) years, 105 (35%) had @entity5 , 26 (9%) suffered an interval @entity2 , and repeat revascularization was required on 29 (10%). Female gender (P = 0.002), pre-operative @entity2 (P = 0.02), significant diagonal disease (P = 0.04) and @entity2 (P = 0.0001) were independently associated with survival. Females were more likely to develop @entity3 (P = 0.03) than their male counterparts. CONCLUSIONS: Survivorship (97%) and event-free survival (96%) at 5 years following coronary artery bypass grafting for isolated left anterior descending coronary artery disease is excellent and equivalent to an age-matched and gender-matched cohort.

title: Long-term clinical outcome following coronary artery bypass grafting for XXXX of the left anterior descending coronary artery.

answer: @entity4


abstract: @entity2 is restricted by the expression of a viral receptor on the surface of the target cell. Retrovirus-mediated gene transfer is therefore not possible in cells that fail to express sufficient levels of the appropriate receptor, representing one major obstacle to the use of recombinant retroviruses in experimental and clinical applications. In this study, we utilized an adenoviral vector to express transiently the receptor for the ecotropic @entity1 @entity3 virus in a panel of @entity0 cell lines. Following @entity2 , the susceptibility to ecotropic retroviral particles of A549, HeLa, RC39 and Meso 33 cells, derived from @entity0 lung epithelium, cervical epithelium, kidney and mesothelium, respectively, was measured on a single-cell basis by the detection of a cell surface marker encoded by the recombinant retrovirus. The marker, termed @entity5 , was found in 10-30%, 25-50% and 50-90% of cells infected at 5, 50 and 250 adenovirus multiplicity of infection, respectively. Southern blot analysis demonstrated the integration of intact retroviral DNA. The integrated vector copy number increased with the adenoviral multiplicity of infection, suggesting that @entity4 is proportional to receptor expression by the target cell, albeit not in a linear fashion. Susceptibility to ecotropic @entity2 was maintained undiminished for at least 3 days, indicating the persistent expression of ecotropic receptor by the adenovirus-transduced cells in that time period and the lack of a major cellular defense triggered by adenovirus infection against the subsequent @entity2 . Thus, the infection of @entity0 cells of various tissues with a recombinant adenovirus expressing the ecotropic @entity1 @entity3 virus receptor generates a window of susceptibility where a high @entity2 rate can be achieved. Increased efficiency of @entity2 obtained in this fashion is amenable to specific regulation via the controlled expression of the adenovirus-encoded retroviral receptor.

title: Adenovirus facilitated infection of XXXX cells with ecotropic retrovirus.

answer: @entity0


abstract: BACKGROUND: Descending @entity1 @entity6 (DNM) is uncommon, and may be lethal if not treated adequately and promptly. Delayed diagnosis of the disease is sometimes encountered in clinical practice. METHODS: Eight consecutive @entity0 with acute DNM were identified between 1991 and 1995, including five @entity0 and three @entity0 . The mean age was 45.8 years (range, 22-71 years). The infectious sources consisted of six esophageal perforations, one cervical cutting @entity2 . The clinical presentations were evaluated. Diagnostic procedures including chest radiograph, sonogram and computerized tomography scans of the chest and neck were examined. Diagnosis and treatment, including culture results from drained fluids and debrided tissues, and antibiotic and supportive therapies were reviewed. RESULTS: Six @entity0 who underwent aggressive surgical treatment recovered well. Two @entity0 who received supportive treatment died of @entity3 alone. The cultured bacteria included: @entity7 , @entity4 , Trichosporum and other mixed @entity5 flora. CONCLUSIONS: Early diagnosis and adequate antibiotic and support therapies are essential to achieve good @entity0 outcomes in acute descending @entity6 . Adequate drainage and debridement, appropriate antibiotic therapy, and sufficient nutritional and respiratory support are the main treatment elements.

title: Management of descending @entity1 XXXX .

answer: @entity6


abstract: BACKGROUND: Descending @entity1 @entity6 (DNM) is uncommon, and may be lethal if not treated adequately and promptly. Delayed diagnosis of the disease is sometimes encountered in clinical practice. METHODS: Eight consecutive @entity0 with acute DNM were identified between 1991 and 1995, including five @entity0 and three @entity0 . The mean age was 45.8 years (range, 22-71 years). The infectious sources consisted of six esophageal perforations, one cervical cutting @entity2 . The clinical presentations were evaluated. Diagnostic procedures including chest radiograph, sonogram and computerized tomography scans of the chest and neck were examined. Diagnosis and treatment, including culture results from drained fluids and debrided tissues, and antibiotic and supportive therapies were reviewed. RESULTS: Six @entity0 who underwent aggressive surgical treatment recovered well. Two @entity0 who received supportive treatment died of @entity3 alone. The cultured bacteria included: @entity7 , @entity4 , Trichosporum and other mixed @entity5 flora. CONCLUSIONS: Early diagnosis and adequate antibiotic and support therapies are essential to achieve good @entity0 outcomes in acute descending @entity6 . Adequate drainage and debridement, appropriate antibiotic therapy, and sufficient nutritional and respiratory support are the main treatment elements.

title: Management of descending XXXX @entity6 .

answer: @entity1


abstract: @entity1 in the athlete has a wide differential diagnosis. @entity0 may originate from structures within the thorax, such as the heart, lungs or oesophagus. However, musculoskeletal causes of @entity1 must be considered. The aim of this review is to help the clinician to diagnose chest wall @entity0 in @entity4 by identifying the possible causes, as reported in the literature. Musculoskeletal problems of the chest wall can occur in the ribs, sternum, articulations or @entity3 . The cause is usually evident in the case of direct trauma. Additionally, @entity4 ' bodies may be subjected to sudden large indirect forces or overuse, and stress fractures of the ribs caused by sporting activity have been extensively reported. These have been associated with golf, rowing and baseball pitching in particular. @entity2 of the sternum reported in wrestlers cause @entity0 and tenderness of the sternum, as expected. Diagnosis is by bone scan and limitation of activity usually allows healing to occur. The @entity8 causes intermittent @entity0 related to posture or movement, and may be diagnosed by the 'hooking manoeuvre', which reproduces @entity0 and sometimes a click. If reassurance and postural advice fail, good results are possible with resection of the mobile rib. The @entity0 is a rare condition that causes @entity0 and tenderness of the xiphoid and is self-limiting. Costochondritis is a self-limiting condition of unknown aetiology that typically presents with @entity0 around the second to fifth @entity5 . It can be differentiated from @entity7 in which there is swelling and @entity0 . Both conditions eventually settle spontaneously although a corticosteroid injection may be useful in particularly troublesome cases. The intercostal muscles may be injured causing tenderness between the ribs. Other conditions that should be considered include @entity6 , precordial catch syndrome and @entity0 from the thoracic spine.

title: Musculoskeletal problems of the chest wall in XXXX .

answer: @entity4


abstract: OBJECTIVE: Forty-seven @entity0 with long-term @entity3 were transferred to the community following the closure of a @entity1 hospital in Sydney. This 6-year evaluation is an extension of a detailed clinical, ethnographic and economic study of the initial 2-years of community transition. METHOD: Quantitative evaluation was conducted using the Brief Psychiatric Rating Scale, Life Skills Profile, Social Behaviour Scale, Montgomery Asberg Depression Rating Scale and Quality Of Life measures. Assessments were completed prior to discharge and at two- and 6-year intervals following community transfer. Repeated measures analysis was utilized to determine changes in outcome variables over time. The residents' perception of 6-years of community living was explored in qualitative semistructured interviews. Details of accommodation, level of care, readmissions, incidents and medication were also documented. RESULTS: During the 6 years following community relocation a total of seven residents returned to hospital for long-term care, three residents died from medical causes and one resident required detention in a corrective services facility. The 36 residents who remained in the community at the 6-year follow-up no longer required intensive 24-h supervision. Living semi-independently, 23 residents resided in two to three @entity0 accommodation with either daily or weekly case manager visits. Clinically, community residents remained stable over the 6 years without significant changes in @entity1 symptoms, @entity2 , living skills or social behaviour problems. Clinical stability was achieved with significant reduction in medication levels over the 6 years. Community-based residents continued to experience improved quality of life and reported their marked preference for living in the community. CONCLUSION: The residents maintained community tenure with significant improvement in quality of life and a reduction in medication, supported by a mental health system with adequate community resources. Issues regarding continuing rehabilitation and social integration need to be addressed. Further deinstitutionalization will require 24-h supervision for most initially and for some on a continuing basis. An ageing population will require specific age related medical and @entity1 services.

title: Deinstitutionalization for long-term XXXX : a 6-year evaluation.

answer: @entity3


abstract: BACKGROUND: Levels of an immunoregulatory and anti-inflammatory cytokine @entity4 are reduced in asthmatic airways, potentially contributing to more intense @entity1 . @entity5 has anti-inflammatory properties and the anti-inflammatory effects of @entity6 and @entity7 have been discussed. OBJECTIVE: The purpose of this study was to define the effect of treatment with @entity5 , @entity6 and @entity7 on the serum level of @entity4 , eosinophil blood counts, eosinophil cationic response (ECP) and clinical parameters (symptom score, FEV1 and PC20H) in @entity0 with moderate @entity3 . METHODS: An 8-week, placebo-controlled and randomized, double-blind trial was carried out. The subjects were 91 @entity0 with moderate @entity8 who were @entity2 to dust mite. @entity0 were randomly allocated to receive 400 microg @entity5 (n = 19), 5 or 10 mg (according to age) @entity6 (n = 18), 24 microg @entity7 (n = 18) or placebo (n = 36). RESULTS: Seventy-nine @entity0 completed the study. After treatment with @entity5 and @entity6 the level of @entity4 in blood serum significantly increased, eosinophil blood counts and ECP levels significantly decreased and all clinical parameters improved; treatment with @entity7 had no effect on @entity4 level, eosinophil blood counts in serum and bronchial hyper-reactivity; ECP level significantly decreased after treatment and @entity3 symptoms and FEV1 improved significantly. Mean @entity4 levels in serum before and after treatment with @entity5 were 7.23 pg/mL with 95% CI, 6.74 -7.72% and 14.24 pg/mL with 95% CI, 11.6-16.88%, respectively (P < 0.001); with @entity6 they were 6.59 pg/mL with 95% CI, 6.26-7.23% and 10.94 pg/mL with 95% CI, 8.24-12.65%, respectively (P < 0.002); with @entity7 they were 7.06 pg/mL with 95% CI, 6.61-7.52% and 7.04 pg/mL with 95% CI, 6.15-7.93%. We found statistically significant correlations between serum level of @entity4 and serum level of ECP after treatment with @entity5 and @entity6 . CONCLUSION: This study demonstrates that one possible way by which @entity5 and @entity6 contribute to inhibition of @entity1 is by increasing @entity4 levels.

title: A randomized, double-blind trial of the effect of glucocorticoid, antileukotriene and beta-agonist treatment on @entity4 serum levels in @entity0 with XXXX .

answer: @entity3


abstract: BACKGROUND: Levels of an immunoregulatory and anti-inflammatory cytokine @entity4 are reduced in asthmatic airways, potentially contributing to more intense @entity1 . @entity5 has anti-inflammatory properties and the anti-inflammatory effects of @entity6 and @entity7 have been discussed. OBJECTIVE: The purpose of this study was to define the effect of treatment with @entity5 , @entity6 and @entity7 on the serum level of @entity4 , eosinophil blood counts, eosinophil cationic response (ECP) and clinical parameters (symptom score, FEV1 and PC20H) in @entity0 with moderate @entity3 . METHODS: An 8-week, placebo-controlled and randomized, double-blind trial was carried out. The subjects were 91 @entity0 with moderate @entity8 who were @entity2 to dust mite. @entity0 were randomly allocated to receive 400 microg @entity5 (n = 19), 5 or 10 mg (according to age) @entity6 (n = 18), 24 microg @entity7 (n = 18) or placebo (n = 36). RESULTS: Seventy-nine @entity0 completed the study. After treatment with @entity5 and @entity6 the level of @entity4 in blood serum significantly increased, eosinophil blood counts and ECP levels significantly decreased and all clinical parameters improved; treatment with @entity7 had no effect on @entity4 level, eosinophil blood counts in serum and bronchial hyper-reactivity; ECP level significantly decreased after treatment and @entity3 symptoms and FEV1 improved significantly. Mean @entity4 levels in serum before and after treatment with @entity5 were 7.23 pg/mL with 95% CI, 6.74 -7.72% and 14.24 pg/mL with 95% CI, 11.6-16.88%, respectively (P < 0.001); with @entity6 they were 6.59 pg/mL with 95% CI, 6.26-7.23% and 10.94 pg/mL with 95% CI, 8.24-12.65%, respectively (P < 0.002); with @entity7 they were 7.06 pg/mL with 95% CI, 6.61-7.52% and 7.04 pg/mL with 95% CI, 6.15-7.93%. We found statistically significant correlations between serum level of @entity4 and serum level of ECP after treatment with @entity5 and @entity6 . CONCLUSION: This study demonstrates that one possible way by which @entity5 and @entity6 contribute to inhibition of @entity1 is by increasing @entity4 levels.

title: A randomized, double-blind trial of the effect of glucocorticoid, antileukotriene and beta-agonist treatment on XXXX serum levels in @entity0 with @entity3 .

answer: @entity4


abstract: BACKGROUND: Levels of an immunoregulatory and anti-inflammatory cytokine @entity4 are reduced in asthmatic airways, potentially contributing to more intense @entity1 . @entity5 has anti-inflammatory properties and the anti-inflammatory effects of @entity6 and @entity7 have been discussed. OBJECTIVE: The purpose of this study was to define the effect of treatment with @entity5 , @entity6 and @entity7 on the serum level of @entity4 , eosinophil blood counts, eosinophil cationic response (ECP) and clinical parameters (symptom score, FEV1 and PC20H) in @entity0 with moderate @entity3 . METHODS: An 8-week, placebo-controlled and randomized, double-blind trial was carried out. The subjects were 91 @entity0 with moderate @entity8 who were @entity2 to dust mite. @entity0 were randomly allocated to receive 400 microg @entity5 (n = 19), 5 or 10 mg (according to age) @entity6 (n = 18), 24 microg @entity7 (n = 18) or placebo (n = 36). RESULTS: Seventy-nine @entity0 completed the study. After treatment with @entity5 and @entity6 the level of @entity4 in blood serum significantly increased, eosinophil blood counts and ECP levels significantly decreased and all clinical parameters improved; treatment with @entity7 had no effect on @entity4 level, eosinophil blood counts in serum and bronchial hyper-reactivity; ECP level significantly decreased after treatment and @entity3 symptoms and FEV1 improved significantly. Mean @entity4 levels in serum before and after treatment with @entity5 were 7.23 pg/mL with 95% CI, 6.74 -7.72% and 14.24 pg/mL with 95% CI, 11.6-16.88%, respectively (P < 0.001); with @entity6 they were 6.59 pg/mL with 95% CI, 6.26-7.23% and 10.94 pg/mL with 95% CI, 8.24-12.65%, respectively (P < 0.002); with @entity7 they were 7.06 pg/mL with 95% CI, 6.61-7.52% and 7.04 pg/mL with 95% CI, 6.15-7.93%. We found statistically significant correlations between serum level of @entity4 and serum level of ECP after treatment with @entity5 and @entity6 . CONCLUSION: This study demonstrates that one possible way by which @entity5 and @entity6 contribute to inhibition of @entity1 is by increasing @entity4 levels.

title: A randomized, double-blind trial of the effect of glucocorticoid, antileukotriene and beta-agonist treatment on @entity4 serum levels in XXXX with @entity3 .

answer: @entity0


abstract: We have recently identified a gene (the @entity1 gene) on @entity0 chromosome 16 (16p13.3) that encodes a secreted protein containing WAP-type, Follistatin/ Kazal type, Kunitz-type and NTR-type protease-inhibitory modules and an Immunoglobulin domain [Trexler et al., Proc. Natl. Acad. Sci. USA 98 (2001), 3705 - 3709]. In the present work we show that a gene on chromosome 17 encodes a @entity2 ( @entity2 ) that has the same domain organization as the @entity1 protein. The exon-intron structure of the two genes is also similar as both genes have a single phase 0 intron that splits their WAP domains in equivalent positions. In view of the presence of several protease inhibitory modules in these proteins it seems likely that they serve to control the action of multiple types of proteases. The tissue expression pattern of the two proteins, however, is markedly different suggesting that they have distinct biological roles. Whereas the @entity1 gene is expressed primarily in adult pancreas, liver and thymus but not in brain and ovary, significant expression of the @entity2 gene is observed in ovary, testis and brain, but not in liver. Pronounced differences could also be seen in the case of fetal tissues: expression of the @entity1 gene was highest in the lung, skeletal muscle and liver, whereas the @entity2 gene was expressed primarily in brain, skeletal muscle, thymus and kidney.

title: Distinct expression pattern of two related XXXX proteins containing multiple types of protease-inhibitory modules.

answer: @entity0


abstract: PURPOSE: Bacterial infections of the air sac have been reported in many nonhuman primates. Approaches to the management of airsacculitis have included combinations of medical and surgical therapies. These strategies have often required repeated attempts to drain exudate from the affected air sac, as well as necessitating that the animal endure isolation or undergo intensive postoperative care before returning to its social group. METHODS: A stoma was created via deliberate apposition of the air sac lining and skin to allow continuous drainage. Antibiotic therapy based on culture and antimicrobial susceptibility of the air sac contents was administered while the @entity1 remained in its social group. RESULTS: We were able to attain complete resolution of the @entity0 after a course of oral antibiotic therapy. The stoma closed gradually over a three-week period, and the @entity1 has remained free of @entity0 since that time. CONCLUSION: Despite the severity of the air sac @entity0 in this @entity1 , we were able to resolve the @entity0 easily, using a simple surgical technique. This method allowed treatment without interfering with social standing or subjection to repeated anesthetic and treatment episodes. This method could be a simple, useful alternative for managing airsacculitis in nonhuman primates.

title: Surgical technique for ambulatory management of airsacculitis in a XXXX ( @entity1 ).

answer: @entity1


abstract: PURPOSE: Bacterial infections of the air sac have been reported in many nonhuman primates. Approaches to the management of airsacculitis have included combinations of medical and surgical therapies. These strategies have often required repeated attempts to drain exudate from the affected air sac, as well as necessitating that the animal endure isolation or undergo intensive postoperative care before returning to its social group. METHODS: A stoma was created via deliberate apposition of the air sac lining and skin to allow continuous drainage. Antibiotic therapy based on culture and antimicrobial susceptibility of the air sac contents was administered while the @entity1 remained in its social group. RESULTS: We were able to attain complete resolution of the @entity0 after a course of oral antibiotic therapy. The stoma closed gradually over a three-week period, and the @entity1 has remained free of @entity0 since that time. CONCLUSION: Despite the severity of the air sac @entity0 in this @entity1 , we were able to resolve the @entity0 easily, using a simple surgical technique. This method allowed treatment without interfering with social standing or subjection to repeated anesthetic and treatment episodes. This method could be a simple, useful alternative for managing airsacculitis in nonhuman primates.

title: Surgical technique for ambulatory management of airsacculitis in a @entity1 ( XXXX ).

answer: @entity1


abstract: @entity3 (PE) production and accumulation in Limnanthes alba Hartw. ex Benth. is associated with flowering. PE content per plant remains fairly constant during the primary growth phase of the plant and only begins to increase significantly above amounts found in the seed once the development of the flower stalk has begun. Both content and concentration increase concomitantly from this point. Distributions in individual plants also associated the highest levels of PE accumulation with the reproductive tissues. This substantiates the association of PE with tissues of greatest fitness value and therefore the hypothesis that they contribute to defence. Analysis of extracts of L. alba tissues by reversed-phase HPLC coupled with ecdysteroid-specific RIA was used to monitor ecdysteroid profiles. RIA-positive peaks co-chromatographing with @entity1 , @entity0 and @entity2 were detected and several tissues also contain PE conjugates. Seedmeal of L. alba appears to be a convenient and promising source for the commercial isolation of the potent PE @entity2 .

title: XXXX levels and distribution during development in Limnanthes alba Hartw. ex Benth. (Limnanthaceae).

answer: @entity3


abstract: BACKGROUND: To evaluate the safety and efficacy of sub-Tenon anesthesia for @entity4 . METHODS: Thirty-two @entity0 diagnosed with @entity5 were treated with @entity4 under sub-Tenon anesthesia. After topical anesthesia, a buttonhole was made through the conjuntiva and Tenon's capsule 4 mm posterior to the limbus. Four milliliters of anesthetic solution was then delivered into the posterior sub-Tenon space using a blunt cannula. The buckling procedure was done immediately after the completion of anesthesia. We evaluated @entity2 and recorded the @entity1 with a visual analogue scale after surgery. RESULTS: There were no anesthesia related complications. Twenty-two @entity0 (69%) reported no @entity1 during surgery. Nine @entity0 (28%) felt @entity1 during surgery. However, the @entity1 was tolerable and the surgeries were finished smoothly with or without a supplemental anesthetic solution. One @entity0 (3%) experienced uncomfortable @entity1 and needed an additional retrobulbar block. Five @entity0 (16%) retained @entity3 5 min after anesthesia, and only 4 @entity0 (13%) experienced total @entity2 . At the end of the surgery, 16 @entity0 (50%) had total @entity2 and 2 @entity0 (6%) retained @entity3 . CONCLUSIONS: Sub-Tenon anesthesia is efficient and safe in @entity4 . It can prevent the complications of peribulbar or retrobulbar anesthesia and is a good alternative to both methods of anesthesia, especially in highly myopic eyes.

title: Sub-tenon anesthesia for XXXX and assessment of postoperative pain.

answer: @entity4