abstract: The Northern Region Lymphoma Group is a population-based group covering 3.1 million @entity0 in Northern England. From 1991 total data collection for all @entity3 @entity0 for this population has been in place and it has been possible to demonstrate that the overall survival for @entity3 for younger @entity0 within this population has moved from 80% pre- 1988 to 87% post- 1988. This improvement has been brought about by the introduction of clinical trials for advanced stage disease and effective salvage regimens. This report describes the outcome of 51 @entity0 treated with the @entity5 , @entity7 and @entity4 (IVE)schedule and includes 28 males and 23 females with a median age of 34 years. Overall 43 of 51 @entity0 responded to treatment (84%) with 31 achieving a complete response, four a good partial response and eight a partial response. Thirty-one proceeded to autologous stem-cell transplantation. In total, with a median follow-up of 24 months (range 6-51), 26 @entity0 remain alive and in continuous remission. @entity2 ,in particular @entity6 WHO grade 4, was observed in all cases but improved over the three courses of treatment. Non-haematological @entity2 was not a major problem, with no significant @entity1 . We conclude that the high-dose @entity5 -containing regimens should be prospectively evaluated in the various types of non-responsive and relapsing @entity3 .

title: Strategic approach to the management of @entity3 incorporating salvage therapy with high-dose @entity5 , @entity7 and XXXX : a Northern Region Lymphoma Group study (UK).

answer: @entity4


abstract: The Northern Region Lymphoma Group is a population-based group covering 3.1 million @entity0 in Northern England. From 1991 total data collection for all @entity3 @entity0 for this population has been in place and it has been possible to demonstrate that the overall survival for @entity3 for younger @entity0 within this population has moved from 80% pre- 1988 to 87% post- 1988. This improvement has been brought about by the introduction of clinical trials for advanced stage disease and effective salvage regimens. This report describes the outcome of 51 @entity0 treated with the @entity5 , @entity7 and @entity4 (IVE)schedule and includes 28 males and 23 females with a median age of 34 years. Overall 43 of 51 @entity0 responded to treatment (84%) with 31 achieving a complete response, four a good partial response and eight a partial response. Thirty-one proceeded to autologous stem-cell transplantation. In total, with a median follow-up of 24 months (range 6-51), 26 @entity0 remain alive and in continuous remission. @entity2 ,in particular @entity6 WHO grade 4, was observed in all cases but improved over the three courses of treatment. Non-haematological @entity2 was not a major problem, with no significant @entity1 . We conclude that the high-dose @entity5 -containing regimens should be prospectively evaluated in the various types of non-responsive and relapsing @entity3 .

title: Strategic approach to the management of XXXX incorporating salvage therapy with high-dose @entity5 , @entity7 and @entity4 : a Northern Region Lymphoma Group study (UK).

answer: @entity3


abstract: The Northern Region Lymphoma Group is a population-based group covering 3.1 million @entity0 in Northern England. From 1991 total data collection for all @entity3 @entity0 for this population has been in place and it has been possible to demonstrate that the overall survival for @entity3 for younger @entity0 within this population has moved from 80% pre- 1988 to 87% post- 1988. This improvement has been brought about by the introduction of clinical trials for advanced stage disease and effective salvage regimens. This report describes the outcome of 51 @entity0 treated with the @entity5 , @entity7 and @entity4 (IVE)schedule and includes 28 males and 23 females with a median age of 34 years. Overall 43 of 51 @entity0 responded to treatment (84%) with 31 achieving a complete response, four a good partial response and eight a partial response. Thirty-one proceeded to autologous stem-cell transplantation. In total, with a median follow-up of 24 months (range 6-51), 26 @entity0 remain alive and in continuous remission. @entity2 ,in particular @entity6 WHO grade 4, was observed in all cases but improved over the three courses of treatment. Non-haematological @entity2 was not a major problem, with no significant @entity1 . We conclude that the high-dose @entity5 -containing regimens should be prospectively evaluated in the various types of non-responsive and relapsing @entity3 .

title: Strategic approach to the management of @entity3 incorporating salvage therapy with high-dose XXXX , @entity7 and @entity4 : a Northern Region Lymphoma Group study (UK).

answer: @entity5


abstract: The Northern Region Lymphoma Group is a population-based group covering 3.1 million @entity0 in Northern England. From 1991 total data collection for all @entity3 @entity0 for this population has been in place and it has been possible to demonstrate that the overall survival for @entity3 for younger @entity0 within this population has moved from 80% pre- 1988 to 87% post- 1988. This improvement has been brought about by the introduction of clinical trials for advanced stage disease and effective salvage regimens. This report describes the outcome of 51 @entity0 treated with the @entity5 , @entity7 and @entity4 (IVE)schedule and includes 28 males and 23 females with a median age of 34 years. Overall 43 of 51 @entity0 responded to treatment (84%) with 31 achieving a complete response, four a good partial response and eight a partial response. Thirty-one proceeded to autologous stem-cell transplantation. In total, with a median follow-up of 24 months (range 6-51), 26 @entity0 remain alive and in continuous remission. @entity2 ,in particular @entity6 WHO grade 4, was observed in all cases but improved over the three courses of treatment. Non-haematological @entity2 was not a major problem, with no significant @entity1 . We conclude that the high-dose @entity5 -containing regimens should be prospectively evaluated in the various types of non-responsive and relapsing @entity3 .

title: Strategic approach to the management of @entity3 incorporating salvage therapy with high-dose @entity5 , XXXX and @entity4 : a Northern Region Lymphoma Group study (UK).

answer: @entity7


abstract: The ribonucleoprotein enzyme telomerase maintains chromosome ends in most eukaryotes and is critical for a cell's genetic stability and its proliferative viability. All telomerases contain a catalytic protein component homologous to viral reverse transcriptases ( @entity4 ) and an RNA (TR) that provides the template sequence as well as a scaffold for ribonucleoprotein assembly. Vertebrate telomerase RNAs have three essential domains: the template, activation and stability domains. Here we report the NMR structure of an essential RNA element derived from the @entity0 telomerase RNA activation domain. The sequence forms a stem-loop structure stabilized by a GU wobble pair formed by two of the five unpaired residues capping a short double helical region. The remaining three loop residues are in a well-defined conformation and form @entity2 -base stacking interactions reminiscent of other RNA loop structures. Mutations of these unpaired @entity3 abolish enzymatic activity. The structure rationalizes a number of biochemical observations, and allows us to propose how the loop may function in the telomerase catalytic cycle. The pre-formed structure of the loop exposes the bases of these three essential @entity3 and positions them to interact with other RNA sequences within TR, with the reverse transcriptase or with the newly synthesized telomeric DNA strand. The functional role of this stem-loop appears to be conserved in even distantly related organisms such as @entity1 and ciliates.

title: The solution structure of an essential stem-loop of XXXX telomerase RNA.

answer: @entity0


abstract: A quick and simple procedure is described for purifying @entity4 from @entity0 whole saliva. The enzyme has been purified about 2700-fold with a yield of approx. 30%. The procedure is based on the immediate fractionation of saliva by ion exchange chromatography. This is followed by a combination of affinity and high performance liquid chromatography. The results indicate that another protein component binds to the enzyme at pH 8.0. The homogeneity of the enzyme has been demonstrated by gel electrophoresis in the absence as well as in the presence of @entity3 . A mol. wt of 40,100 +/- 1800 has been calculated from gel electrophoresis experiments. Sedimentation equilibrium in an analytical ultracentrifuge gave a mol. wt of 39,700. The @entity1 composition has been determined and it confirms that the enzyme has a low isoelectric point. The presence of @entity2 has been demonstrated by absorption and fluorescence spectroscopy.

title: The purification of XXXX from @entity0 whole saliva.

answer: @entity4


abstract: A quick and simple procedure is described for purifying @entity4 from @entity0 whole saliva. The enzyme has been purified about 2700-fold with a yield of approx. 30%. The procedure is based on the immediate fractionation of saliva by ion exchange chromatography. This is followed by a combination of affinity and high performance liquid chromatography. The results indicate that another protein component binds to the enzyme at pH 8.0. The homogeneity of the enzyme has been demonstrated by gel electrophoresis in the absence as well as in the presence of @entity3 . A mol. wt of 40,100 +/- 1800 has been calculated from gel electrophoresis experiments. Sedimentation equilibrium in an analytical ultracentrifuge gave a mol. wt of 39,700. The @entity1 composition has been determined and it confirms that the enzyme has a low isoelectric point. The presence of @entity2 has been demonstrated by absorption and fluorescence spectroscopy.

title: The purification of @entity4 from XXXX whole saliva.

answer: @entity0


abstract: @entity7 or cholesteastoma is a @entity3 . It usually arises in the paramedian cisterns of the posterior fossa. Its incidence varies between 0.2 and 1% of all @entity1 . The cerebello-pontine angle (CPA) is the most common localization. Our study reports 10 observations of CPA @entity7 , treated in our department between 1989 and 1999. The age of our @entity0 ranged from 20 to 45 years, with male predominance. The @entity0 were admitted with symptoms of @entity6 or signs of @entity8 . CT-scan was performed in all cases and MRI was performed in 5 @entity0 . The audiometric explorations only provided an orienting contribution. Treatment was exclusively surgical. The retro-sigmoid approach was used in 6 cases, the sub-occipital in 30% and a subtemporal approach in one case. Total resection of the @entity7 was accomplished in 4 cases, and subtotal resection in 4 cases. Two @entity0 underwent partial resection and underwent a revision procedure. The histological examination showed an @entity7 in all cases. The clinical course was controlled in 6 @entity0 : 4 @entity0 recovered and became symptom free. A persisting @entity2 was observed in two cases ( @entity4 , @entity9 ); 4 @entity0 were lost to follow-up. @entity7 is a @entity1 . Total resection is the ideal treatment, but we have to be aware, taking into consideration the adherence of the @entity1 to @entity5 , of the risks at attempting total resection.

title: [ XXXX of the cerebellopontine angle. A surgical series of 10 cases and review of the literature].

answer: @entity7


abstract: PURPOSE: The advent of intraocular lens implantation after pediatric @entity1 surgery necessitates an increased understanding of refractive development. The significant variation in rate and amount of refractive change among eyes, both aphakic and pseudophakic, is well recognized, although the causes of such variation remain unclear. The purpose of this study was to determine if a correlation exists between the rate of refractive growth (RRG) and visual acuity outcome in pediatric @entity2 . METHODS: Multicenter, retrospective observational case series. One hundred and twenty-five eyes of 85 @entity0 with @entity1 surgery before 1 year of age and a minimum of 3 years of follow-up were analyzed. RRG was calculated for each eye using the logarithmic model of ocular growth and compared with final logMAR acuity using linear regression. RESULTS: The correlation of RRG with final logMAR acuity was statistically significant (r(2) = 0.10; P <.01), ie, 10% of variance in RRG is related to acuity outcome. The correlation was higher in unilaterally aphakic @entity0 (n = 44; r(2) = 0.19; P <.01) than in bilaterally aphakic @entity0 (n = 81; r(2) = 0.08; P <.01). Eyes with visual acuity of 20/60 or better had a significantly lower RRG than those with poorer acuity (4.1 v 5.4 diopters (D); P <.01). CONCLUSIONS: RRG in @entity2 is correlated with visual acuity outcome. Eyes with poorer acuity have a greater RRG.

title: The association between myopic shift and visual acuity outcome in pediatric XXXX .

answer: @entity2


abstract: The purpose of this pilot study was to explore whether co-meditation, shared or cross-breathing, could reduce @entity1 and enhance relaxation in a nursing school setting. The specific outcomes to be assessed in the quantitative component were blood pressure, pulse, respirations, and @entity1 , both state and trait. A qualitative component explored @entity0 ' experiences with co-meditation following 1 month of practice. Rogers's Science of Unitary @entity0 Beings formed the theoretical basis for this study. The study employed a pretest/posttest design with @entity0 as their own controls. Quantitative data were collected from a convenience sample of 26 students, faculty, and staff aged 19 to 51 years, male and female. Fourteen @entity0 returned for the qualitative component. Findings suggest that co-meditation may be useful in reducing @entity1 , as measured by vital signs and the @entity1 inventory forms. @entity0 reported feeling calmer and more relaxed, balanced, and centered following 1 month of practice. Findings suggest that co-meditation has potential to help transform a nursing educational environment from one that is potentially @entity1 provoking to a calmer, more caring one.

title: Exploring co-meditation as a means of reducing XXXX and facilitating relaxation in a nursing school setting.

answer: @entity1


abstract: UNASSIGNED: Bombesin-like receptor 3 ( @entity3 -3) is an X-linked G protein-coupled receptor involved in the regulation of energy homeostasis. @entity4 null ( @entity4 -/y) @entity0 become @entity1 . To date, no high affinity endogenous ligand has been identified. In an effort to detect a circulating endogenous @entity3 -3 ligand, we generated parabiotic pairs of @entity0 between @entity4 -/y and @entity2 ( @entity2 ) @entity0 or between @entity2 controls. Successful parabiosis was demonstrated by circulatory dye exchange. The @entity4 -/y- @entity2 and @entity2 lost similar weight immediately after surgery. After 9 weeks on a high fat diet, the @entity4 -/y- @entity2 pairs weighed more than the @entity2 . Within the @entity4 -/y- @entity2 pairs, the @entity4 -/y @entity0 had greater adiposity than the @entity2 @entity0 , but comparable lean and liver weights. Compared to @entity2 @entity0 in @entity2 , @entity4 -/y and @entity2 @entity0 in @entity4 -/y- @entity2 pairs each had greater lean mass, and the @entity4 -/y @entity0 also had greater adiposity. These results contrast to those reported for parabiotic pairs of leptin receptor null (Leprdb/db) and @entity2 @entity0 , where high leptin levels in the Leprdb/db @entity0 cause the @entity2 parabiotic partners to lose weight. Our data demonstrate that a circulating endogenous @entity3 -3 ligand, if present, is not sufficient to reduce adiposity in parabiotic partners of @entity4 -/y @entity0 .

title: Search for an Endogenous Bombesin-Like Receptor 3 ( XXXX -3) Ligand Using Parabiotic @entity0 .

answer: @entity3


abstract: UNASSIGNED: Bombesin-like receptor 3 ( @entity3 -3) is an X-linked G protein-coupled receptor involved in the regulation of energy homeostasis. @entity4 null ( @entity4 -/y) @entity0 become @entity1 . To date, no high affinity endogenous ligand has been identified. In an effort to detect a circulating endogenous @entity3 -3 ligand, we generated parabiotic pairs of @entity0 between @entity4 -/y and @entity2 ( @entity2 ) @entity0 or between @entity2 controls. Successful parabiosis was demonstrated by circulatory dye exchange. The @entity4 -/y- @entity2 and @entity2 lost similar weight immediately after surgery. After 9 weeks on a high fat diet, the @entity4 -/y- @entity2 pairs weighed more than the @entity2 . Within the @entity4 -/y- @entity2 pairs, the @entity4 -/y @entity0 had greater adiposity than the @entity2 @entity0 , but comparable lean and liver weights. Compared to @entity2 @entity0 in @entity2 , @entity4 -/y and @entity2 @entity0 in @entity4 -/y- @entity2 pairs each had greater lean mass, and the @entity4 -/y @entity0 also had greater adiposity. These results contrast to those reported for parabiotic pairs of leptin receptor null (Leprdb/db) and @entity2 @entity0 , where high leptin levels in the Leprdb/db @entity0 cause the @entity2 parabiotic partners to lose weight. Our data demonstrate that a circulating endogenous @entity3 -3 ligand, if present, is not sufficient to reduce adiposity in parabiotic partners of @entity4 -/y @entity0 .

title: Search for an Endogenous Bombesin-Like Receptor 3 ( @entity3 -3) Ligand Using Parabiotic XXXX .

answer: @entity0


abstract: Blocks of linkage disequilibrium (LD) in the @entity0 genome represent segments of ancestral chromosomes. To investigate the relationship between LD and genealogy, we analysed diversity associated with restriction fragment length polymorphism (RFLP) haplotypes of the 5' @entity1 gene complex. Genealogical analyses were based on sequence alleles that spanned a 12.2-kb interval, covering 3.1 kb around the psibeta gene and 6.2 kb of the @entity2 gene and its 5' flanking sequence known as the R/T region. Diversity was sampled from a Kenyan Luo population where recent malarial selection has contributed to substantial LD. A single common sequence allele spanning the 12.2-kb interval exclusively identified the ancestral chromosome bearing the "Bantu" beta(s) (sickle-cell) RFLP haplotype. Other common 5' RFLP haplotypes comprised interspersed segments from multiple ancestral chromosomes. Nucleotide diversity was similar between psibeta and R/T- @entity2 but was non-uniformly distributed within the R/T- @entity2 region. High diversity associated with the 5' R/T identified two ancestral lineages that probably date back more than 2 million years. Within this genealogy, variation has been introduced into the 3' R/T by gene conversion from other ancestral chromosomes. Diversity in @entity2 was found to lead through parts of the main genealogy but to coalesce in a more recent ancestor. The well-known recombination hotspot is clearly restricted to the region 3' of @entity2 . Our analyses show that, whereas one common haplotype in a block of high LD represents a long segment from a single ancestral chromosome, others are mosaics of short segments from multiple ancestors related in genealogies of unsuspected complexity.

title: Common 5' XXXX RFLP haplotypes harbour a surprising level of ancestral sequence mosaicism.

answer: @entity1


abstract: OBJECTIVE: To validate the utility of the Berg Balance Scale (BBS) in predicting length of stay (LOS) and discharge destination for @entity0 admitted to a @entity1 rehabilitation unit. DESIGN: Prospective study. SETTING: Provincial tertiary inpatient @entity1 unit for a primarily geriatric population. @entity0 : A total of 313 of the 325 @entity0 admitted consecutively between April 1998 and August 2000. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: LOS and discharge destination. RESULTS: Admission BBS scores correlated negatively with LOS (r=-.53, controlling for age). Logistic regression confirmed that the following were independent predictors of being discharged home rather than to an institution (adjusted odds ratio, 95% confidence interval): admission BBS (1.09, 1.06-1.12) and the presence of family supports (15.0, 7.2-31.3). These results generally concur with previously published results, obtained at a different @entity1 rehabilitation setting. CONCLUSIONS: This study validates the use of the BBS scores in assisting to estimate approximate LOS and eventual discharge destination. Age did not correlate significantly with the outcomes measured in this study, which was conducted in a geriatric population.

title: Validation of the Berg Balance Scale as a predictor of length of stay and discharge destination in XXXX rehabilitation.

answer: @entity1


abstract: miRNAs are regulatory RNA molecules. The analytical interest rose over the past 10 years especially in clinical diagnostics as miRNAs show specific expression patterns in several @entity0 diseases like @entity2 or @entity1 . Therefore, it is expected that miRNA profiles might be used as biomarkers in early diagnosis. The idea of establishing biomarkers is also present in veterinary drug analysis, e.g. in the surveillance of illegal use of anabolics. Transcriptomics is a promising approach in the detection of anabolics misuse. However, miRNA expression patterns have shown their superiority over mRNA patterns in clinical diagnostics. Thus, the influence of @entity4 on miRNA expression in @entity3 liver should be investigated and an expression pattern should be validated, which might be used as a treatment biomarker. An animal experiment was conducted with 18 heifers equally allocated to a control and a treatment group, which was implanted with TBA plus E2. Liver samples were screened for miRNA expression using PCR arrays. Expression of 11 prominent miRNAs was validated via single assay qPCR. Herein, the following expression pattern could be found with an up-regulation of @entity5 and miR-103 and a down-regulation of @entity6 , @entity7 , @entity8 and @entity9 (p<0.05 each). Using principal components analysis (PCA), the control group could clearly be distinguished from the treatment group, when integrating gene expression results from both miRNA and mRNA. So, the combination of different transcribed targets (mRNA plus miRNA) might be a promising approach to find a valid expression pattern to be used for anabolic treatment screening.

title: Changes in the miRNA profile under the influence of @entity4 in XXXX liver.

answer: @entity3


abstract: miRNAs are regulatory RNA molecules. The analytical interest rose over the past 10 years especially in clinical diagnostics as miRNAs show specific expression patterns in several @entity0 diseases like @entity2 or @entity1 . Therefore, it is expected that miRNA profiles might be used as biomarkers in early diagnosis. The idea of establishing biomarkers is also present in veterinary drug analysis, e.g. in the surveillance of illegal use of anabolics. Transcriptomics is a promising approach in the detection of anabolics misuse. However, miRNA expression patterns have shown their superiority over mRNA patterns in clinical diagnostics. Thus, the influence of @entity4 on miRNA expression in @entity3 liver should be investigated and an expression pattern should be validated, which might be used as a treatment biomarker. An animal experiment was conducted with 18 heifers equally allocated to a control and a treatment group, which was implanted with TBA plus E2. Liver samples were screened for miRNA expression using PCR arrays. Expression of 11 prominent miRNAs was validated via single assay qPCR. Herein, the following expression pattern could be found with an up-regulation of @entity5 and miR-103 and a down-regulation of @entity6 , @entity7 , @entity8 and @entity9 (p<0.05 each). Using principal components analysis (PCA), the control group could clearly be distinguished from the treatment group, when integrating gene expression results from both miRNA and mRNA. So, the combination of different transcribed targets (mRNA plus miRNA) might be a promising approach to find a valid expression pattern to be used for anabolic treatment screening.

title: Changes in the miRNA profile under the influence of XXXX in @entity3 liver.

answer: @entity4


abstract: PURPOSE: @entity5 was induced during prolonged exercise (ExH) and passive heating ( @entity7 ) to isolate the influence of exercise on neuromuscular function during a maximal voluntary isometric contraction (MVC) of the quadriceps under heat stress. The influence of @entity2 in limiting endurance performance in the heat was also examined. METHODS: On separate days, eight males cycled to exhaustion at 60% maximal @entity0 uptake or were immersed in a water bath (   41  C) until rectal temperature (Tre) increased to 39.5  C. The ExH and @entity7 interventions were performed in ambient conditions of 38  C and 60% relative humidity with Tre reaching 39.8  C during exercise. Before (control) and after each intervention, voluntary activation and force production capacity were evaluated by superimposing an electrically stimulated @entity4 during a 45-s MVC. RESULTS: Force production decreased immediately after @entity7 and ExH compared with control, with the magnitude of decline being more pronounced after ExH (P < 0.01). Mean voluntary activation was also significantly @entity6 after both interventions (P < 0.01 vs control). However, the extent of decline in voluntary activation was maintained at    90% during both @entity7 and ExH MVC. This decline accounted for 41.5% ( @entity7 ) and 33.1% (ExH) of the decrease in force production. In addition, exhaustion coincided with a marked increase in HR (   96% of maximum) and a decline in @entity1 volume (25%) and mean arterial pressure (10%) (P < 0.05). CONCLUSIONS: The loss of force production capacity during @entity5 originated from central and peripheral fatigue factors, with the combination of heat stress and previous contractile activity exacerbating the rate of decline. Thus, the observed significant rise in thermal strain in ExH and @entity7 @entity3 and was associated with an exercise performance limiting increase in @entity2 .

title: Central and peripheral fatigue during passive and exercise-induced XXXX .

answer: @entity5


abstract: This study was conducted to investigate the interactions between growth hormone (GH) and insulin-like growth factor-I ( @entity6 ) on @entity0 (P4) secretion by porcine luteal cells cultured in vitro. Cells isolated from corpora lutea (CL) collected at three different periods of the luteal phase (CL1--early luteal phase; CL2--middle luteal phase and CL3--late luteal phase) were incubated with different doses of GH (10, 100 or 200 ng/ml). After 48 h cultures were terminated and the media were frozen until further P4 concentration analysis. GH (100 ng/ml) increased P4 secretion by CL1 and CL2 and had no effect on CL3. In separate studies these cells were treated for 48 h with @entity6 alone or with GH combined with @entity6 . @entity6 alone increased basal P4 secretion only by cells collected from CL1 while concurrent treatment with GH had no effect on P4 secretion by any type of CL. To investigate the possible mechanism of GH and @entity6 mediated induction of P4 secretion, an inhibitory study was conducted. In this experiment, luteal cells collected from CL1 were cultured in the absence or presence of @entity3 (an inhibitor of protein synthesis) or @entity5 (an inhibitor of DNA transcription). @entity3 or @entity5 completely blocked the stimulatory effect of both GH and @entity6 on P4 production but did not reduce basal @entity0 secretion suggesting involvement of gene transcription and translation in the GH and @entity6 action on luteal cells. Additionally, the activity of @entity2 dehydrogenase (3 beta-HSD) under the influence of GH added alone or together with IGF was measured by the conversion of @entity4 to @entity0 . Stimulation of P4 secretion in P5-treated cells in GH-stimulated cultures was not observed, however, high stimulatory effect was noted in @entity6 treated cultures. In conclusion, the present studies indicate that there is direct and cycle stage dependent influence of GH and @entity6 on steroidogenesis in procine luteal cells. It is suggested that both IGF and GH may exert some regulatory action during CL development in the @entity1 .

title: Growth hormone and insulin-like growth factor-I action on XXXX secretion by porcine corpora lutea isolated at various periods of the luteal phase.

answer: @entity0


abstract: AIMS: To present a new approach for estimating the "true prevalence" of @entity1 and apply it to datasets from Peru, Vietnam, and Cambodia. METHODS: Bayesian models were developed for estimating both the @entity1 prevalence using different diagnostic tests (microscopy, PCR _ ELISA), without the need of a gold standard, and the tests' characteristics. Several sources of information, i.e. data, expert opinions and other sources of knowledge can be integrated into the model. This approach resulting in an optimal and harmonized estimate of @entity0 prevalence, with no conflict between the different sources of information, was tested on data from Peru, Vietnam and Cambodia. RESULTS: @entity1 sero-prevalence was relatively low in all sites, with ELISA showing the highest estimates. The sensitivity of microscopy and ELISA were statistically lower in Vietnam than in the other sites. Similarly, the specificities of microscopy, ELISA and PCR were significantly lower in Vietnam than in the other sites. In Vietnam and Peru, microscopy was closer to the "true" estimate than the other 2 tests while as expected ELISA, with its lower specificity, usually overestimated the prevalence. CONCLUSIONS: Bayesian methods are useful for analyzing prevalence results when no gold standard diagnostic test is available. Though some results are expected, e.g. PCR more sensitive than microscopy, a standardized and context-independent quantification of the diagnostic tests' characteristics (sensitivity and specificity) and the underlying @entity1 prevalence may be useful for comparing different sites. Indeed, the use of a single diagnostic technique could strongly bias the prevalence estimation. This limitation can be circumvented by using a Bayesian framework taking into account the imperfect characteristics of the currently available diagnostic tests. As discussed in the paper, this approach may further support global @entity1 burden estimation initiatives.

title: True versus apparent XXXX prevalence: the contribution of a Bayesian approach.

answer: @entity0


abstract: INTRODUCTION: The chronic @entity1 are heterogeneous entities by the functional, lesional and evolutive point of view. Ethiopathogenic factors involved in chronic @entity1 are genetical factors, combines with environmental factors, hormonal factors, infectious factors etc. The exact role of smoking on the autoimmune mechanism is unclear, but smoking is known to have an antithyroid effect. AIM: Our study tries to estimate the influence of smoking on serum levels of antithyroid peroxidase antibodies and antithyroglobulin antibodies, in a group of @entity0 with various clinical forms of chronic @entity1 . MATERIALS AND METHODS: We studied a group consists of 310 @entity0 with chronic @entity1 , hospitalised in the Endocrinology Department of Constanta County Hospital, between January 2006 - December 2009. We detected serum values of antithyroidperoxidase antibodies and antithyroglobulin antibodies of our @entity0 . We also followed the age, sex and presence of smoking in our study group. For statistical processing of the data we use Student's t-test. RESULTS AND DISCUSSIONS: In our study group 24.28% of @entity0 were smokers. Serum levels of antithyroid peroxidase antibodies were significantly increased (p < 0.001) in the smokers @entity0 , compared with the nonsmokers patients. Serum levels of antithyroglobulin antibodies were significantly increased (p < 0.01) in smokers @entity0 , compared with those who were nonsmokers. CONCLUSIONS: Smoking increased the serum levels of antithyroid antibodies in @entity0 with chronic @entity1 .

title: [Smoking and chronic XXXX ].

answer: @entity1


abstract: This study was undertaken to determine the prevalence of LE cells in synovial fluid and their importance for the diagnosis of @entity3 . Synovial fluid was obtained from 631 @entity0 : 31 with @entity5 ( @entity5 ), 337 with @entity2 ( @entity2 ), 4 with @entity9 , 9 with @entity4 ( @entity4 ), 27 with the @entity8 ( @entity2 / @entity5 ), 132 with @entity6 ( @entity6 ), 57 with @entity11 , and 34 with @entity10 ( @entity10 ). The fluid was centrifuged, precipitate smears were done and were May-Gr  nwald-Giemsa stained for cytologic assessment. The supernatant was collected for antinuclear antibody (ANA) testing. Physicochemical and serologic properties of the synovial fluid were routinely determined. All synovial fluids demonstrated signs of @entity1 . The presence of LE cells was ascertained in five @entity0 with @entity5 and nine @entity0 with the @entity8 . In these cases, LE cells were accompanied by ANA. In addition, @entity7 bodies were revealed in @entity5 @entity0 . LE cells were observed in 2.6% of @entity0 with @entity2 but were not accompanied by ANA. @entity0 with @entity4 , @entity9 , @entity6 , @entity11 , and @entity10 tested negative for LE cells. It appears from these results that LE cells are rarely present in the synovial fluid of @entity0 with @entity3 . In contrast, they occur in more than 40% of @entity0 with the @entity8 and may thus be regarded as important for the diagnosis of this condition.

title: [LE cells in synovial fluid: prevalence and diagnostic usefulness in XXXX ].

answer: @entity3


abstract: UNASSIGNED: @entity6 ( @entity3 , @entity7 , and glycitein) are bioactive compounds with mildly estrogenic properties and often referred to as phytoestrogen. These are present in significant quantities (up to 4-5  mg.g(-1) on dry basis) in legumes mainly @entity5 , green beans, mung beans. In grains (raw materials) they are present mostly as glycosides, which are poorly absorbed on consumption. Thus, @entity5 are processed into various food products for digestibility, taste and bioavailability of nutrients and bioactives. Main processing steps include steaming, cooking, roasting, microbial fermentation that destroy protease inhibitors and also cleaves the glycoside bond to yield absorbable aglycone in the processed soy products such as miso, natto, soy milk, tofu; and increase shelf lives. Processed soy food products have been an integral part of regular diets in many Asia-Pacific countries for centuries e.g. China, Japan and Korea. However, in the last two decades, there have been concerted efforts to introduce soy products in western diets for their health benefits with some success. @entity6 were hailed as magical natural component that attribute to prevent some major prevailing health concerns, Consumption of soy products have been linked to reduction in incidence or severity of @entity1 such as @entity0 , @entity4 , @entity2 etc. Overall, consuming moderate amounts of traditionally prepared and minimally processed soy foods may offer modest health benefits while minimizing potential for any adverse health effects.

title: An Updated Review of Dietary XXXX : Nutrition, Processing, Bioavailability and Impacts on Human Health.

answer: @entity6


abstract: STUDY DESIGN: Retrospective review of medical records and radiographs. OBJECTIVE: We assessed the clinical outcomes of @entity5 ( @entity5 ) after traumatic, combat-related injuries, and to review our management of these distinct injuries and report our preliminary follow-up. SUMMARY OF BACKGROUND DATA: @entity5 injuries are an anatomic separation of the pelvis from the spinal column, and are the result of high-energy @entity1 . A relative increase in these injuries has been seen in young healthy combat casualties subjected to high-energy blast @entity1 . METHODS: We performed a retrospective review of inpatient/outpatient medical records and radiographs for all @entity0 treated at our institution with combat-related @entity5 . Twenty-three @entity0 met inclusion criteria of combat-related @entity5 with one-year follow-up. @entity0 were treated as follows: no fixation (9), sacroiliac screw fixation (8), posterior spinal fusion (5) and sacral plate (1). All @entity0 with radiographic evidence of a zone III sacral @entity3 , in addition to associated lumbar @entity3 indicating loss of the iliolumbar ligamentous complex integrity were included. RESULTS: In 15 @entity0 , the sacral @entity3 were an H or U type zone III @entity3 , whereas in the remaining nine, the sacral @entity3 was severely comminuted and unable to classify (six open @entity3 ). There was no difference in visual analog scale (VAS) between treatment modalities. Two open injuries had @entity4 . One @entity0 treated with an L4-ilium posterior spinal fusion with instrumentation required instrumentation removal for @entity4 . At a mean follow-up of 1.71 years (range, 1-4.5), 11 @entity0 (48%) still reported residual @entity2 and the mean VAS at latest follow-up was 1.7 (range, 0-7). CONCLUSION: Operative stabilization promoted healing and earlier mobilization, but carries a high-postoperative risk of @entity4 . Nonoperative management should be considered in @entity0 whose comorbidities prevent safe stabilization.

title: Retrospective review of XXXX in blast injuries.

answer: @entity5


abstract: BACKGROUND: Population-based studies have shown that nearly one third of @entity0 with @entity1 undergo @entity3 ( @entity3 ) before undergoing laparoscopic cholecystectomy (LC) (two-stage approach). The present study was designed to evaluate the safety of single-stage laparoscopic management to avoid preoperative @entity3 . MATERIALS AND METHODS: Between June 1998 and June 2002, 35 female @entity0 and 10 male @entity0 (median age, 59 years) with uncomplicated mild @entity1 were studied prospectively and reviewed retrospectively. LC with fluoroscopic intraoperative cholangiography (IOC) or with fluoroscopic IOC and laparoscopic CBD exploration in cases of concomitant @entity2 was performed as the definitive treatment (single-stage approach). @entity0 underwent surgery electively when symptoms had subsided and laboratory parameters had improved. RESULTS: LC alone was performed in 39 @entity0 , and an additional laparoscopic CBD exploration was performed in the remaining six. In one @entity0 , IOC yielded a false-positive result. CBD stones were detected in four cases, and debris in the CBD in one case, for an 11% incidence of concomitant @entity2 . The conversion rate was zero, and single-stage laparoscopic treatment was successful in all cases. The overall morbidity rate was 4%. The 30-day postoperative mortality rate was zero. CONCLUSION: Although preoperative @entity3 and sphincterotomy still have a role in complicated cases of mild @entity1 , laparoscopic single-stage definitive treatment is feasible and safe in uncomplicated cases of disease when local experience is available.

title: Single-stage definitive laparoscopic management in mild XXXX .

answer: @entity1


abstract: OBJECTIVE: To explore the improvement of hand motion function, @entity3 and self-care ability of daily life for @entity1 @entity0 treated with floating-needle combined with rehabilitation training. METHODS: Eighty hand @entity3 @entity0 of post- @entity1 within one year after @entity1 were randomly divided into an observation group and a control group, 40 cases in each one. In the two groups, rehabilitation was adopted for eight weeks,once a day,40 min one time. In the observation group, based on the above treatment and according to @entity2 trigger point, 2~3 points in both the internal and external sides of forearm were treated with floating-needle. The positive or passive flexion and extension of wrist and knuckle till the relief of @entity3 hand was combined. The floating-needle therapy was given for eight weeks, on the first three days once a day and later once every other day. Modified Ashworth Scale( @entity4 ), activity of daily life(ADL, Barthel index) scores and Fugl-Meyer(FMA) scores were used to assess the @entity3 hand degree,activity of daily life and hand motion function before and after 7-day, 14-day and 8-week treatment. RESULTS: After 7-day, 14-day and 8-week treatment, @entity4 scores were apparently lower than those before treatment in the two groups(all P<0. 05), and Barthel scores and FMA scores were obviously higher than those before-treatment(all P<0. 05). After 14-day and 8-week treatment, FMA scores in the observation group were markedly higher than those in the control group(both P<0. 05). CONCLUSION: Floating-needle therapy combined with rehabilitation training and simple rehabilitation training could both improve hand @entity3 degree, hand function and activity of daily life of post- @entity1 @entity0 , but floating-needle therapy combined with rehabilitation training is superior to simple rehabilitation training for the improvement of hand function.

title: [The effect of floating-needle therapy combined with rehabilitation training for the hand function recovery of post- XXXX @entity0 ].

answer: @entity1


abstract: OBJECTIVE: To explore the improvement of hand motion function, @entity3 and self-care ability of daily life for @entity1 @entity0 treated with floating-needle combined with rehabilitation training. METHODS: Eighty hand @entity3 @entity0 of post- @entity1 within one year after @entity1 were randomly divided into an observation group and a control group, 40 cases in each one. In the two groups, rehabilitation was adopted for eight weeks,once a day,40 min one time. In the observation group, based on the above treatment and according to @entity2 trigger point, 2~3 points in both the internal and external sides of forearm were treated with floating-needle. The positive or passive flexion and extension of wrist and knuckle till the relief of @entity3 hand was combined. The floating-needle therapy was given for eight weeks, on the first three days once a day and later once every other day. Modified Ashworth Scale( @entity4 ), activity of daily life(ADL, Barthel index) scores and Fugl-Meyer(FMA) scores were used to assess the @entity3 hand degree,activity of daily life and hand motion function before and after 7-day, 14-day and 8-week treatment. RESULTS: After 7-day, 14-day and 8-week treatment, @entity4 scores were apparently lower than those before treatment in the two groups(all P<0. 05), and Barthel scores and FMA scores were obviously higher than those before-treatment(all P<0. 05). After 14-day and 8-week treatment, FMA scores in the observation group were markedly higher than those in the control group(both P<0. 05). CONCLUSION: Floating-needle therapy combined with rehabilitation training and simple rehabilitation training could both improve hand @entity3 degree, hand function and activity of daily life of post- @entity1 @entity0 , but floating-needle therapy combined with rehabilitation training is superior to simple rehabilitation training for the improvement of hand function.

title: [The effect of floating-needle therapy combined with rehabilitation training for the hand function recovery of post- @entity1 XXXX ].

answer: @entity0


abstract: @entity9 rarely occur in the retropharynx with only three cases reported in the current literature. The most common symptom associated with @entity9 is @entity5 . We report a @entity9 with an unusual clinical presentation of @entity1 and @entity2 . A 42-year-old @entity0 presented with incapacitating @entity6 , @entity1 , @entity3 , as well as @entity5 . Neurological workup was normal. Imaging revealed a hyperdense, ill-defined, diffuse right retropharyngeal mass suggestive of a possible @entity8 with no communication with the cervical spine. Surgical removal was uneventful and associated with a postoperative @entity7 . In follow-up, @entity5 and neck symptoms improved. @entity9 can occur in a wide age range of @entity0 . @entity4 via a cervical approach offers definitive therapy but may be associated with an iatrogenic @entity7 for which the @entity0 should be counseled prior to operative intervention. @entity6 is an atypical symptom that needs to be worked up to rule out a communication with the spinal column prior to surgical removal. @entity0 must be counseled that atypical symptoms may not completely resolve with surgical treatment.

title: XXXX presenting with @entity1 : report of a case and review of literature.

answer: @entity9


abstract: @entity9 rarely occur in the retropharynx with only three cases reported in the current literature. The most common symptom associated with @entity9 is @entity5 . We report a @entity9 with an unusual clinical presentation of @entity1 and @entity2 . A 42-year-old @entity0 presented with incapacitating @entity6 , @entity1 , @entity3 , as well as @entity5 . Neurological workup was normal. Imaging revealed a hyperdense, ill-defined, diffuse right retropharyngeal mass suggestive of a possible @entity8 with no communication with the cervical spine. Surgical removal was uneventful and associated with a postoperative @entity7 . In follow-up, @entity5 and neck symptoms improved. @entity9 can occur in a wide age range of @entity0 . @entity4 via a cervical approach offers definitive therapy but may be associated with an iatrogenic @entity7 for which the @entity0 should be counseled prior to operative intervention. @entity6 is an atypical symptom that needs to be worked up to rule out a communication with the spinal column prior to surgical removal. @entity0 must be counseled that atypical symptoms may not completely resolve with surgical treatment.

title: @entity9 presenting with XXXX : report of a case and review of literature.

answer: @entity1


abstract: Failure to deliver drug effectively to the lungs is a common cause of referrals with "difficult @entity3 ". This may be due to poor regime compliance or poor device compliance (lack of competence and/or contrivance). The former is the more difficult to address. The latter can be addressed providing the healthcare professional is aware of the principles underlying aerosol delivery and aspects of @entity0 behaviour. Unlike the gastrointestinal tract, the airways have evolved to exclude foreign material. A narrow window of opportunity exists with particles in the size range 1-7 micro m having a relatively high probability of depositing within the airways once inhaled. Current delivery systems are able to generate particles in this size range but they all have associated problems that may significantly impair the effectiveness of drug delivery to the lungs. While there is little evidence that compliance with inhaled therapy is significantly worse than with oral therapy, there is evidence that lack of competence (the inability to use a device effectively) or contrivance (knowing how to use a device effectively but contriving to use it ineffectively) are major additional impediments to effective therapy. Ensuring that the delivery system is acceptable to the @entity0 is particularly important in the very young. The device chosen with a @entity0 should be one that can and will be used effectively. For inhaled @entity2 , the choice of device/drug combination should be limited to those with a good therapeutic index (i.e. the majority of any systemic exposure should result from the lung dose). The best guide to determining the appropriate dose of inhaled @entity1 is to use the lowest effective dose.

title: Role of inhaler competence and contrivance in "difficult XXXX ".

answer: @entity3


abstract: INTRODUCTION: Endoscopic stenting (ES) is a minimally invasive alternative to surgical gastroenterostomy (GE) for palliation of @entity1 . This consecutive, retrospective analysis compares the clinical outcome of all @entity0 undergoing ES or GE in the same period. METHODS: ES was performed at the Endoscopy Department, University Hospital Mannheim or at the Interdisciplinary Endoscopy Department, University Hospital Hamburg-Eppendorf. GE was performed at the Surgical Department, University Hospital Mannheim. All palliative ES or GE on @entity0 with @entity1 without earlier gastric resections between January 2001 and April 2007 were evaluated. Main outcome measurements were ability of solid food intake ( @entity3 score), persistence of @entity4 (gut function score), length of hospital stay, morbidity, mortality and re-interventions. RESULTS: A total of 44 ES and 43 GE were performed. @entity2 and vomiting--measured by means of the gut function score--persisted in significantly more @entity0 in the GE group than in those who underwent stent placement (p = 0.0102). The @entity3 score at discharge from the hospital revealed no significant difference in the ability of solid food intake between the groups. The hospital stay was significantly longer in the GE group (p = 0.0003). There was no significant difference in mortality and the rates of complications and re-interventions. CONCLUSION: In this study, ES is a generally equivalent--and in several points superior--alternative to GE for palliation of @entity1 . ES seems to be the less invasive alternative for symptomatic @entity0 . GE has good results in @entity0 with longer survival and can be practiced within abdominal explorations.

title: XXXX : retrospective comparison of endoscopic and surgical palliative therapy.

answer: @entity1


abstract: BACKGROUND: The focus in minimally invasive mitral valve surgery has been on reducing thoracic incisions. Several cardiac incisions described in these procedures do not conform with the philosophy of "minimal invasiveness". We describe the left @entity3 which has the potential of facilitating an excellent mitral valve exposure through a limited cardiac incision, without major @entity1 . The safety, efficacy and technical ease of this technique for minimally invasive mitral valve surgery is evaluated. METHODS: From July 1998 to December 2000, 95 consecutive @entity0 underwent mitral valve surgery by the same surgeon. The @entity0 were divided into 2 groups on the basis of the cardiac incision used for correction of @entity2 . Group I @entity0 had left @entity3 and group II @entity0 had the traditional paraseptal incision. Each group was further classified into the minimally invasive sternotomy and standard sternotomy subgroups. The clinical variables and complications in the 2 groups were compared. RESULTS: There were 40 male and 55 female @entity0 with a mean age of 63 +/-12yrs (range 29 to 88yrs). LARI was used for mitral valve exposure in 81 @entity0 (85%). In 18 @entity0 (19%), surgery was by minimally invasive technique. The mitral valve was replaced in 82% of @entity0 and repaired in 18%. LARI provided a better exposure of the mitral valve in its anatomical and physiological disposition, without distortion. There was no significant difference in the cross clamp times and postoperative complications between the 2 groups. More @entity0 in the LARI group regained sinus rhythm at discharge. CONCLUSION: LARI is safe and technically easy to perform. It provides an excellent exposure of the mitral valve and left heart cavities in its anatomical disposition with minimal @entity1 , making it ideal for minimally invasive mitral surgery.

title: The left XXXX : an asset for minimally invasive mitral valve surgery.

answer: @entity3


abstract: BACKGROUND: In @entity0 immunodeficiency virus treatment adequate virological suppression is warranted, nevertheless for some @entity0 it remains a challenge. We investigated factors associated with @entity2 ( @entity2 ) and @entity1 ( @entity1 ) under combined antiretroviral therapy (cART). MATERIALS AND METHODS: We analysed @entity0 receiving standard regimens between 1st July 2012 and 1st July 2013 with at least one viral load (VL) measurement below the quantification limit (BLQ) in their treatment history. After a minimum of 6 months of unmodified cART, the next single VL measurement within 6 months was analysed. @entity1 was defined as @entity3 RNA levels >= 200 copies/mL and all other quantifiable measurements were classified as @entity2 . Factors associated with @entity2 and @entity1 compared to BLQ were identified by logistic regression models. RESULTS: Of 2276 @entity0 , 1972 (86.6%) were BLQ, 222 (9.8%) showed @entity2 and 82 (3.6%) had @entity1 . A higher risk for @entity2 and @entity1 was shown in @entity0 with cART interruptions and in @entity0 with boosted PI therapy. The risk for @entity2 and @entity1 was lower in @entity0 from centres using the Abbott compared to the Roche assay to measure VL. A higher risk for @entity2 but not for @entity1 was found in @entity0 with a higher VL before cART [for >99.999 copies/mL: aOR (95% CI): 4.19 (2.07-8.49); for 10.000-99.999 copies/mL: aOR (95% CI): 2.52 (1.23-5.19)] and shorter cART duration [for <9 months: aOR (95% CI): 2.59 (1.38-4.86)]. A higher risk for @entity1 but not for @entity2 was found in younger @entity0 [for <30 years: aOR (95% CI): 2.76 (1.03-7.35); for 30-50 years: aOR (95% CI): 2.70 (1.26-5.79)], @entity0 originating from high prevalence countries [aOR (95% CI): 2.20 (1.09-4.42)] and in male injecting drug users [aOR (95% CI): 2.72 (1.38-5.34)]. CONCLUSIONS: For both @entity1 and @entity2 , factors associated with adherence play a prominent role. Furthermore, performance characteristics of the diagnostic assay used for VL quantification should also be taken into consideration.

title: Factors Associated with Low-Level Viraemia and Virological Failure: Results from the Austrian XXXX Cohort Study.

answer: @entity3


abstract: INTRODUCTION: Prevalence of planned pregnancies varies between countries but is often measured in a dichotomous manner. The aim of this study was to investigate to what level pregnant @entity0 had planned their pregnancies and whether pregnancy planning was associated with background characteristics and pregnancy- @entity1 . MATERIAL AND METHODS: A cross-sectional study that utilized the baseline measurements from the Swedish Pregnancy Planning study. Pregnant @entity0 (n = 3390) recruited at antenatal clinics answered a questionnaire. Data were analyzed with multinomial logistic regression, @entity4 and chi-squared tests. RESULTS: Three of four pregnancies were very or fairly planned and 12% fairly or very unplanned. Of @entity0 with very unplanned pregnancies, 32% had considered an induced abortion. @entity0 with planned pregnancies were more likely to have a higher level of education, higher household income, to be currently working (>= 50%) and to have longer relationships than @entity0 with unplanned pregnancies. The level of pregnancy planning was associated with @entity1 , such as information-seeking and intake of @entity5 , but without a reduction in @entity2 consumption. One-third of all @entity0 took @entity5 1 month prior to conception, 17% used @entity3 daily and 11% used @entity2 weekly 3 months before conception. CONCLUSIONS: A majority rated their pregnancy as very or fairly planned, with socio-economic factors as explanatory variables. The level of pregnancy planning should be queried routinely to enable individualized counseling, especially for @entity0 with unplanned pregnancies. Preconception recommendations need to be established and communicated to the public to increase health promoting @entity1 .

title: Is pregnancy planning associated with background characteristics and pregnancy- XXXX ?

answer: @entity1


abstract: BACKGROUND: Venom sac extract of @entity5 was toxic in @entity0 when injected intraperitoneally but not toxic when injected subcutaneously. Necropsy showed the @entity2 to be an inflammatory response. METHODS: Venom peptide and protein fractions were tested to identify the inflammatory components. The active components were tested to establish whether they might function as adjuvant for venom protein-specific antibody response. RESULTS: @entity2 required the synergistic action of two venom components, a mast cell degranulating peptide mastoparan and phospholipase A1. Both components stimulated @entity3 release from @entity0 peritoneal cells and macrophages. Mastoparan showed a weak activity to enhance IgE and @entity6 responses to a yellow jacket venom protein Ves v 5 in BALB/c @entity0 . It was not possible to assess the adjuvant activity of phospholipase A1 because of its suppression of Ves v 5-specific response. @entity7 , a mast cell degranulating peptide from @entity4 venom, was inactive as an adjuvant for Ves v 5-specific response. CONCLUSION: Yellow jacket venom contains two inflammatory components, mastoparan and phospholipase A1. Our findings suggest that mastoparan can function as a weak adjuvant for @entity1 cell-associated antibody response.

title: Inflammatory role of two venom components of yellow jackets ( XXXX ): a mast cell degranulating peptide mastoparan and phospholipase A1.

answer: @entity5


abstract: Irradiation with UV-A of normal @entity0 fibroblasts in @entity1 -buffered saline induced cell death, measured as lack of colony-forming ability. A specially filtered sunlamp, emitting wavelengths greater than 330 nm, was used as UV-A source. After UV-A irradiation, single-strand breaks (alkali-labile bonds) could be detected in DNA; these lesions were rapidly repaired. The induction of these single-strand breaks was almost eliminated when irradiation was performed in the presence of catalase. However, catalase, when present during UV-A irradiation, did not reduce cell death of the fibroblasts. Excision repair, monitored as unscheduled DNA synthesis, was induced strongly by irradiation with UV-C (predominantly 254 nm), but could not be detected after UV-A irradiation. Moreover, very little accumulation of incision breaks during post-irradiation incubation with @entity2 and @entity5 (araC) was detected after UV-A. This is consistent with the low amount of @entity4 dimers (measured as UV-endonuclease susceptible sites) induced by UV-A. @entity3 fibroblasts of complementation group A, which are extremely sensitive to UV-C irradiation, showed the same sensitivity to UV-A as normal fibroblasts. The results indicate that lethality by UV-A wavelengths greater than 330 nm is caused by lesions other than single-strand breaks (alkali-labile bonds) and @entity4 dimers.

title: The induction and repair of DNA damage and its influence on cell death in primary XXXX fibroblasts exposed to UV-A or UV-C irradiation.

answer: @entity0


abstract: OBJECTIVE: This retrospective study describes our experience with the diagnosis, treatment, results and long-term follow-up of @entity4 ( @entity4 ). @entity0 AND METHODS: Nineteen @entity0 diagnosed with @entity4 were reviewed. Seven @entity0 presented with stage I(E) disease, four with stage II(E) (regional lymphadenopathy), and eight with @entity2 (disseminated bone involvement). Only one stage IV @entity0 exhibited 'B' symptoms. The majority (72%) demonstrated diffuse, large cell, B-type @entity4 . All @entity0 were treated with @entity3 -based chemotherapy and consolidation radiotherapy to the primary site (8 @entity0 : early @entity4 ) or the most bulky area (3 @entity0 : stage IV @entity4 ). RESULTS: Ten stage I(E)/II(E) @entity0 are alive with no evidence of disease (NED) and only one died due to metastatic @entity1 while with NED from his @entity4 . Eight stage IV @entity0 are alive with NED. Median follow-up for all living @entity0 : 77 months. Side effects were mild and did not necessitate delay in treatment. CONCLUSIONS: Our departmental policy of treating @entity4 @entity0 with an @entity6 -based regimen and involved field radiotherapy proved to be successful in achieving excellent long-term, disease-free survival. Phase III randomized, controlled, clinical trials will determine the true role of consolidation radiotherapy in @entity4 , when considering severe late side effects, including radiation-induced @entity5 .

title: Primary XXXX --a retrospective study. Experience at the Northern Israel Oncology Center (1979-2000).

answer: @entity4


abstract: The prevalence of mutations in the @entity4 ( @entity4 ) gene in @entity3 has been shown to be increased. The aim of this study was to prospectively analyze the frequency of such mutations in a homogeneous group of @entity0 with @entity1 studied in a French Gastroenterology department. @entity0 AND METHODS: Between April 1999 and December 2001, all @entity0 with unexplained chronic or recurrent acute @entity1 were studied. Other causes of @entity1 were excluded and no @entity0 had personal signs or family history compatible with @entity2 . Following informed written consent, genetic analysis for @entity4 was performed using an oligonucleotid ligation assay, on the 31 most frequently known mutations of the @entity4 gene. A complementary analysis for variants in exons 9, 10 and 17a, thought to be implicated in atypical @entity2 , was also performed using denaturing gradient gel electrophoresis. RESULTS: @entity1 occurred in 64 @entity0 (chronic, n=30; recurrent acute, n=34) with a median age of 36 years. Eighteen @entity4 mutations or variants were detected in 16 @entity0 (25%): DeltaF508 (n=7), @entity5 (n=2), @entity6 (n=4), 5T (n=5). Two @entity0 were compound heterozygous. The frequency of DeltaF508 mutations was greater than that of the general population (10.9 vs 2.4%; P<0.001). @entity1 was diagnosed at a median age of 32 years in mutation-positive @entity0 compared to 39 in mutation-negative @entity0 . The prevalence of @entity4 mutations was 35.5% in @entity0 < or =35 years against 15.1% in those > 35 years (P=0.06). The clinical course of @entity1 (severity and complication rates) was not altered by the presence of a mutation. CONCLUSION: One-quarter of all @entity0 and one-third of those < or =35 years with @entity1 have at least one mutation of the @entity4 gene. The presence of a @entity4 mutation appears to predict the development of @entity1 at an earlier age.

title: [Frequency of @entity4 gene mutations in XXXX ].

answer: @entity1


abstract: The prevalence of mutations in the @entity4 ( @entity4 ) gene in @entity3 has been shown to be increased. The aim of this study was to prospectively analyze the frequency of such mutations in a homogeneous group of @entity0 with @entity1 studied in a French Gastroenterology department. @entity0 AND METHODS: Between April 1999 and December 2001, all @entity0 with unexplained chronic or recurrent acute @entity1 were studied. Other causes of @entity1 were excluded and no @entity0 had personal signs or family history compatible with @entity2 . Following informed written consent, genetic analysis for @entity4 was performed using an oligonucleotid ligation assay, on the 31 most frequently known mutations of the @entity4 gene. A complementary analysis for variants in exons 9, 10 and 17a, thought to be implicated in atypical @entity2 , was also performed using denaturing gradient gel electrophoresis. RESULTS: @entity1 occurred in 64 @entity0 (chronic, n=30; recurrent acute, n=34) with a median age of 36 years. Eighteen @entity4 mutations or variants were detected in 16 @entity0 (25%): DeltaF508 (n=7), @entity5 (n=2), @entity6 (n=4), 5T (n=5). Two @entity0 were compound heterozygous. The frequency of DeltaF508 mutations was greater than that of the general population (10.9 vs 2.4%; P<0.001). @entity1 was diagnosed at a median age of 32 years in mutation-positive @entity0 compared to 39 in mutation-negative @entity0 . The prevalence of @entity4 mutations was 35.5% in @entity0 < or =35 years against 15.1% in those > 35 years (P=0.06). The clinical course of @entity1 (severity and complication rates) was not altered by the presence of a mutation. CONCLUSION: One-quarter of all @entity0 and one-third of those < or =35 years with @entity1 have at least one mutation of the @entity4 gene. The presence of a @entity4 mutation appears to predict the development of @entity1 at an earlier age.

title: [Frequency of XXXX gene mutations in @entity1 ].

answer: @entity4


abstract: Since 1998, the Epidemiological Survelliance System of Navarra has included the notification of 34 transmissible @entity3 , to which are added epidemic outbreaks of any aetiology and cause. Reporting to the system is carried out on a weekly basis by every doctor who suspects, or diagnoses, any of these processes. In our autonomous community, @entity2 ( @entity2 ) are reported using standardised forms on a weekly basis to the Section of Infectious Diseases and Control of Outbreaks of the Public Health Institute. Notification is made by the doctors and/or paediatricians of Primary Care and by certain services of Specialised Care. Subsequently, the information is sent to the National Epidemiology Centre where data from the Autonomous Communities is centralised and diffused. The year 2002 marks the fifth year of the new Epidemiological Vigilance System. In these five years there have been 74,814 notifications of disease, 17,184 in the year 2002, which provides a balance of notification of 74.07% for this year. In 2002, under the heading of respiratory transmitted diseases, 24,870 cases of Inluenza were reported, Epidemic Index (EI: 0.80). 58% of total annual cases were reported in the first nine weeks of the year, with a maximum in week 4 when 3,277 cases were reported. 16 cases of @entity8 were reported to the system (EI: 1.07). All the cases were confirmed microbiologically and all appeared in a sporadic way. With respect to the causative serogroup, on 12 occasions @entity6 serogroup B was isolated and in the 4 remaining cases serogroup C was isolated. One case was notified in @entity0 of less than 2 years of age (Rate: 10.52 cases per 100,000), another case in @entity0 between 2 and 5 years (5.52 cases per 100,000), 5 cases in the age group of 6 to 19 years (Rate: 5.86 cases per 100,000) and the remaining nine cases in the age group of @entity0 aged 20 years or over (2.2 per 100,000). 70 cases of @entity4 were declared in 2002 (EI: 4.67), all but one under the clinical form of @entity1 . Twenty-two of the cases were presented in the context of two outbreaks with a community origin, which affected 17 and 5 @entity0 respectively. Similarly, there was a notable increase in the declaration of cases of @entity7 , with 6 cases (EI: 2.00), @entity5 , with 10 cases (EI: 1.67) and chickenpox, with 4,346 notified cases (EI: 1.61).

title: [ XXXX ( @entity2 ) in Navarra. 2002].

answer: @entity2


abstract: Since 1998, the Epidemiological Survelliance System of Navarra has included the notification of 34 transmissible @entity3 , to which are added epidemic outbreaks of any aetiology and cause. Reporting to the system is carried out on a weekly basis by every doctor who suspects, or diagnoses, any of these processes. In our autonomous community, @entity2 ( @entity2 ) are reported using standardised forms on a weekly basis to the Section of Infectious Diseases and Control of Outbreaks of the Public Health Institute. Notification is made by the doctors and/or paediatricians of Primary Care and by certain services of Specialised Care. Subsequently, the information is sent to the National Epidemiology Centre where data from the Autonomous Communities is centralised and diffused. The year 2002 marks the fifth year of the new Epidemiological Vigilance System. In these five years there have been 74,814 notifications of disease, 17,184 in the year 2002, which provides a balance of notification of 74.07% for this year. In 2002, under the heading of respiratory transmitted diseases, 24,870 cases of Inluenza were reported, Epidemic Index (EI: 0.80). 58% of total annual cases were reported in the first nine weeks of the year, with a maximum in week 4 when 3,277 cases were reported. 16 cases of @entity8 were reported to the system (EI: 1.07). All the cases were confirmed microbiologically and all appeared in a sporadic way. With respect to the causative serogroup, on 12 occasions @entity6 serogroup B was isolated and in the 4 remaining cases serogroup C was isolated. One case was notified in @entity0 of less than 2 years of age (Rate: 10.52 cases per 100,000), another case in @entity0 between 2 and 5 years (5.52 cases per 100,000), 5 cases in the age group of 6 to 19 years (Rate: 5.86 cases per 100,000) and the remaining nine cases in the age group of @entity0 aged 20 years or over (2.2 per 100,000). 70 cases of @entity4 were declared in 2002 (EI: 4.67), all but one under the clinical form of @entity1 . Twenty-two of the cases were presented in the context of two outbreaks with a community origin, which affected 17 and 5 @entity0 respectively. Similarly, there was a notable increase in the declaration of cases of @entity7 , with 6 cases (EI: 2.00), @entity5 , with 10 cases (EI: 1.67) and chickenpox, with 4,346 notified cases (EI: 1.61).

title: [ @entity2 ( XXXX ) in Navarra. 2002].

answer: @entity2


abstract: A retrospective study of 25 @entity0 with severe soft tissue @entity1 to the perineum from the last 14 years was performed to determine the most appropriate management strategy for these problematic wounds. There were 20 (80%) @entity0 and 5 (20%) @entity0 with an average age of 29 years. Six (24%) @entity0 died of exsanguination from their pelvic @entity1 within the first few hours of presentation. The remaining 19 @entity0 were taken to the operating room for sigmoidoscopy, diverting colostomy, distal rectal washout, and radical debridement and irrigation of any devitalized tissue. Enteral access by jejunostomy was obtained in six @entity0 . Most @entity0 underwent daily debridement and pulsatile irrigation for at least three days, but usually longer, until the treating surgeon deemed the wound to be clean. None of the @entity0 managed in this fashion developed @entity2 . However, @entity2 did occur in all four @entity0 who did not receive early mandatory daily debridement. Total parenteral nutrition was required in eight @entity0 because there were significant delays in the ability of these @entity0 to resume oral intake. In most previously published series in which daily debridement was not performed, a @entity2 rate of 40% to 80% was reported. Therefore, to optimize the clinical course and recovery from these complex wounds, we conclude that mandatory daily debridement with pulsatile irrigation should be instituted in conjunction with sigmoidoscopy, diversion of the fecal stream, distal rectal irrigation, enteral access, and initial radical debridement of devitalized tissue.

title: Management of complex perineal XXXX .

answer: @entity1


abstract: It is presently unclear how much @entity4 ( @entity4 ) loss is needed to induce favorable metabolic changes. Cross-sectional studies have proposed that a threshold level of @entity4 exceeding 110 cm(2) in @entity0 induces deleterious changes in the metabolic profile. It is presently unclear, however, if significant decreases in @entity4 below this given threshold significantly improve the metabolic profile more as compared to decreases that remain below 110 cm(2). To examine whether achieving versus not achieving the proposed @entity4 threshold impacts differently on the metabolic profile in postmenopausal @entity0 , we examined the effects of a @entity4 loss below the 110-cm(2) threshold versus those individuals who remained higher than 110 cm(2) after a @entity3 program. Twenty-five sedentary @entity1 (baseline % body fat, 47.7% +/- 4.1%; [mean +/- SD]) postmenopausal @entity0 aged between 51 and 71 years (59.7 +/- 5.6 years) and displaying high baseline levels of @entity4 accumulation (223 +/- 45 cm(2)) were submitted to a 1-year @entity3 program with weight stabilization periods before and after weight reduction. Based on their loss of @entity4 after @entity3 , subjects were characterized as "attainers" (post @entity4 levels < 110 cm(2); average, 96 +/- 10 cm(2); n = 10) or "non-attainers" (post @entity4 levels > 110 cm(2); average, 171 +/- 34 cm(2); n = 15). We compared changes in (1) plasma lipid-lipoprotein levels, (2) insulin sensitivity (euglycemic/hyperinsulinemic clamp), and (3) supine resting blood pressure between groups who achieved these 2 distinct levels of @entity4 . Attainers showed a 2-fold greater loss of @entity4 compared to non-attainers (-51.5% v -27.5%, P <.001). Attainers also showed a greater loss of body weight (-19.0% v -12.5%, P <.01) and fat mass (-34.8% v -18.4%, P <.001) after the program compared to non-attainers. Despite significant differences in the loss of total fat and @entity4 after the @entity3 program, attainers and non-attainers showed comparable improvements for plasma high-density lipoprotein- @entity2 (HDL-chol) levels (+62.5% v +50.0%, P = not significant [NS]), @entity2 /HDL-chol ratio (-45.5% v -36.5%, P = NS), insulin sensitivity (+34.1% v +23.2%, P = NS), and resting systolic (-6.9% v -5.1%, P = NS) and diastolic (-11.3% v -11.1%, P = NS) blood pressure. These results do not favor the idea that attaining levels of @entity4 below a threshold of 110 cm(2) is necessary to favorably improve the metabolic profile in @entity1 postmenopausal @entity0 . Achieving or not the proposed threshold of @entity4 , independently of baseline values, appears to yield similar metabolic improvements in @entity1 postmenopausal @entity0 . More moderate losses of @entity4 appear to yield similar metabolic improvements as large losses.

title: Is there a threshold of visceral fat loss that improves the metabolic profile in XXXX postmenopausal @entity0 ?

answer: @entity1


abstract: It is presently unclear how much @entity4 ( @entity4 ) loss is needed to induce favorable metabolic changes. Cross-sectional studies have proposed that a threshold level of @entity4 exceeding 110 cm(2) in @entity0 induces deleterious changes in the metabolic profile. It is presently unclear, however, if significant decreases in @entity4 below this given threshold significantly improve the metabolic profile more as compared to decreases that remain below 110 cm(2). To examine whether achieving versus not achieving the proposed @entity4 threshold impacts differently on the metabolic profile in postmenopausal @entity0 , we examined the effects of a @entity4 loss below the 110-cm(2) threshold versus those individuals who remained higher than 110 cm(2) after a @entity3 program. Twenty-five sedentary @entity1 (baseline % body fat, 47.7% +/- 4.1%; [mean +/- SD]) postmenopausal @entity0 aged between 51 and 71 years (59.7 +/- 5.6 years) and displaying high baseline levels of @entity4 accumulation (223 +/- 45 cm(2)) were submitted to a 1-year @entity3 program with weight stabilization periods before and after weight reduction. Based on their loss of @entity4 after @entity3 , subjects were characterized as "attainers" (post @entity4 levels < 110 cm(2); average, 96 +/- 10 cm(2); n = 10) or "non-attainers" (post @entity4 levels > 110 cm(2); average, 171 +/- 34 cm(2); n = 15). We compared changes in (1) plasma lipid-lipoprotein levels, (2) insulin sensitivity (euglycemic/hyperinsulinemic clamp), and (3) supine resting blood pressure between groups who achieved these 2 distinct levels of @entity4 . Attainers showed a 2-fold greater loss of @entity4 compared to non-attainers (-51.5% v -27.5%, P <.001). Attainers also showed a greater loss of body weight (-19.0% v -12.5%, P <.01) and fat mass (-34.8% v -18.4%, P <.001) after the program compared to non-attainers. Despite significant differences in the loss of total fat and @entity4 after the @entity3 program, attainers and non-attainers showed comparable improvements for plasma high-density lipoprotein- @entity2 (HDL-chol) levels (+62.5% v +50.0%, P = not significant [NS]), @entity2 /HDL-chol ratio (-45.5% v -36.5%, P = NS), insulin sensitivity (+34.1% v +23.2%, P = NS), and resting systolic (-6.9% v -5.1%, P = NS) and diastolic (-11.3% v -11.1%, P = NS) blood pressure. These results do not favor the idea that attaining levels of @entity4 below a threshold of 110 cm(2) is necessary to favorably improve the metabolic profile in @entity1 postmenopausal @entity0 . Achieving or not the proposed threshold of @entity4 , independently of baseline values, appears to yield similar metabolic improvements in @entity1 postmenopausal @entity0 . More moderate losses of @entity4 appear to yield similar metabolic improvements as large losses.

title: Is there a threshold of visceral fat loss that improves the metabolic profile in @entity1 postmenopausal XXXX ?

answer: @entity0


abstract: PURPOSE: To analyze the genetic and epigenetic alterations affecting the @entity8 , @entity6 , @entity7 , and p21WAF1 @entity2 suppressor genes, loss of heterozygosity (LOH) at 3q and 18q, and the clinical variables of a series of Spanish @entity0 with @entity5 . These genetic changes were tested for an association with prognosis. METHODS: Peripheral blood samples and clinical data were available from 76 @entity0 with @entity5 . Paired tissue was available from 41 of them. The mutation and methylation status of @entity7 , p21WAF1, @entity6 , and @entity8 was screened as well as LOH at 3q and 18q. RESULTS: Loss of heterozygosity affecting @entity8 (37.2%), @entity6 (42.3%), and 18q (30.8%) and @entity6 mutation (39%) were frequently encountered. @entity6 mutation was associated with diagnosis at a later age. @entity8 alteration was associated with reduced survival and event-free survival. The clinical variables associated with poor prognosis were the presence of @entity1 at diagnosis (P = 0.035) or during treatment (P = 0.016) and the chondroblastic histologic subtype (P = 0.007); the response to induction chemotherapy (<90% @entity3 ) also tended to be related to poor prognosis (P = 0.08). CONCLUSIONS: @entity8 , @entity6 , and possibly other @entity2 suppressor genes located at 18q and other localizations are involved in pediatric @entity4 , together with other genetic alterations not fully understood to date. Based on these results, the presence of an altered @entity8 gene should be regarded as a poor prognostic factor for @entity5 .

title: Genetic and epigenetic alterations of the cell cycle regulators and @entity2 suppressor genes in XXXX .

answer: @entity5


abstract: PURPOSE: To analyze the genetic and epigenetic alterations affecting the @entity8 , @entity6 , @entity7 , and p21WAF1 @entity2 suppressor genes, loss of heterozygosity (LOH) at 3q and 18q, and the clinical variables of a series of Spanish @entity0 with @entity5 . These genetic changes were tested for an association with prognosis. METHODS: Peripheral blood samples and clinical data were available from 76 @entity0 with @entity5 . Paired tissue was available from 41 of them. The mutation and methylation status of @entity7 , p21WAF1, @entity6 , and @entity8 was screened as well as LOH at 3q and 18q. RESULTS: Loss of heterozygosity affecting @entity8 (37.2%), @entity6 (42.3%), and 18q (30.8%) and @entity6 mutation (39%) were frequently encountered. @entity6 mutation was associated with diagnosis at a later age. @entity8 alteration was associated with reduced survival and event-free survival. The clinical variables associated with poor prognosis were the presence of @entity1 at diagnosis (P = 0.035) or during treatment (P = 0.016) and the chondroblastic histologic subtype (P = 0.007); the response to induction chemotherapy (<90% @entity3 ) also tended to be related to poor prognosis (P = 0.08). CONCLUSIONS: @entity8 , @entity6 , and possibly other @entity2 suppressor genes located at 18q and other localizations are involved in pediatric @entity4 , together with other genetic alterations not fully understood to date. Based on these results, the presence of an altered @entity8 gene should be regarded as a poor prognostic factor for @entity5 .

title: Genetic and epigenetic alterations of the cell cycle regulators and XXXX suppressor genes in @entity5 .

answer: @entity2


abstract: BACKGROUND: @entity6 is an emerging zoonotic pathogen and is the leading cause of @entity5 in adults in Vietnam. Systematic data on the antimicrobial susceptibility profiles of @entity6 strains isolated from @entity0 cases are lacking. We studied antimicrobial resistance and associated resistance determinants in @entity6 isolated from @entity0 with @entity1 in southern Vietnam. METHODS: @entity6 strains isolated between 1997 and 2008 were investigated for their susceptibility to six antimicrobial agents. Strains were screened for the presence and expression of @entity2 and @entity4 resistance determinants and the association of tet(M) genes with Tn916- like transposons. The localization of @entity2 resistance gene tet(L) was determined by pulse field gel electrophoresis and Southern blotting. RESULTS: We observed a significant increase in resistance to @entity2 and @entity3 , which was concurrent with an increase in multi-drug resistance. In @entity2 resistance strains, we identified tet(M), tet(O), tet(W) and tet(L) and confirmed their expression. All tet(M) genes were associated with a Tn916-like transposon. The co-expression of tet(L) and other @entity2 resistance gene(s) encoding for ribosomal protection protein(s) was only detected in strains with a minimum inhibitory concentration (MIC) of @entity2 of >=  64 mg/L. CONCLUSIONS: We demonstrated that multi-drug resistance in @entity6 causing disease in @entity0 in southern Vietnam has increased over the 11-year period studied. We report the presence and expression of tet(L) in @entity6 strains and our data suggest that co-expression of multiple genes encoding distinct mechanism is required for an MIC >=  64 mg/L to @entity2 .

title: The antimicrobial resistance patterns and associated determinants in XXXX isolated from @entity0 in southern Vietnam, 1997-2008.

answer: @entity6


abstract: BACKGROUND: @entity6 is an emerging zoonotic pathogen and is the leading cause of @entity5 in adults in Vietnam. Systematic data on the antimicrobial susceptibility profiles of @entity6 strains isolated from @entity0 cases are lacking. We studied antimicrobial resistance and associated resistance determinants in @entity6 isolated from @entity0 with @entity1 in southern Vietnam. METHODS: @entity6 strains isolated between 1997 and 2008 were investigated for their susceptibility to six antimicrobial agents. Strains were screened for the presence and expression of @entity2 and @entity4 resistance determinants and the association of tet(M) genes with Tn916- like transposons. The localization of @entity2 resistance gene tet(L) was determined by pulse field gel electrophoresis and Southern blotting. RESULTS: We observed a significant increase in resistance to @entity2 and @entity3 , which was concurrent with an increase in multi-drug resistance. In @entity2 resistance strains, we identified tet(M), tet(O), tet(W) and tet(L) and confirmed their expression. All tet(M) genes were associated with a Tn916-like transposon. The co-expression of tet(L) and other @entity2 resistance gene(s) encoding for ribosomal protection protein(s) was only detected in strains with a minimum inhibitory concentration (MIC) of @entity2 of >=  64 mg/L. CONCLUSIONS: We demonstrated that multi-drug resistance in @entity6 causing disease in @entity0 in southern Vietnam has increased over the 11-year period studied. We report the presence and expression of tet(L) in @entity6 strains and our data suggest that co-expression of multiple genes encoding distinct mechanism is required for an MIC >=  64 mg/L to @entity2 .

title: The antimicrobial resistance patterns and associated determinants in @entity6 isolated from XXXX in southern Vietnam, 1997-2008.

answer: @entity0


abstract: INTRODUCTION: Non-intensive care unit (ICU) cohorts have shown an association between inflammatory disturbances and @entity6 , though these relationships have not been studied in @entity10 @entity0 . This study sought to investigate the relationship between two inflammatory biomarkers, @entity8 and @entity7 ( @entity7 ), and duration of acute @entity3 in ventilated @entity0 . METHODS: @entity0 enrolled in the Maximizing Efficacy of Targeted Sedation and Reducing @entity2 (MENDS) trial were assessed daily for @entity6 using the Confusion Assessment Method-ICU. Plasma levels of @entity8 and @entity7 were obtained within 24 hours of enrollment. Proportional odds logistic regression was used to examine the association between @entity8 and @entity7 separately with @entity6 / @entity5 -free days, adjusting for age, acute physiology score (APS) of the Acute Physiology And Chronic Health Evaluation (APACHE) II, sedation group ( @entity11 vs. @entity9 ), and @entity4 . Secondary analyses examined the association of these markers with other organ dysfunctions and 28-day survival. RESULTS: Eighty-seven @entity0 were included in this analysis. The median age of the @entity0 was 60 years with APACHE II scores of 28; 68% had @entity4 within 48 hours of admission. Higher levels of @entity8 were associated with fewer @entity6 / @entity5 -free days [odds ratio (OR), 0.5; 95% confidence interval (CI), 0.3 to 1.0; P = 0.04], whereas higher @entity7 levels showed trends towards fewer @entity6 / @entity5 -free days (OR, 0.6; 95% CI, 0.3 to 1.1; P = 0.08). Similar relationships were found regardless of the presence of @entity4 . No associations were found between @entity8 or @entity7 with 28-day survival (P = 0.40 and 0.16, respectively). CONCLUSIONS: In our pilot study, high baseline inflammatory biomarkers predicted prolonged periods of acute @entity3 , implicating @entity1 as an important mechanism in the pathophysiology of @entity6 and @entity5 during @entity10 , irrespective of whether @entity0 had @entity4 or not.

title: XXXX and @entity7 levels at admission as predictors of duration of acute @entity3 in @entity10 @entity0 .

answer: @entity8


abstract: INTRODUCTION: Non-intensive care unit (ICU) cohorts have shown an association between inflammatory disturbances and @entity6 , though these relationships have not been studied in @entity10 @entity0 . This study sought to investigate the relationship between two inflammatory biomarkers, @entity8 and @entity7 ( @entity7 ), and duration of acute @entity3 in ventilated @entity0 . METHODS: @entity0 enrolled in the Maximizing Efficacy of Targeted Sedation and Reducing @entity2 (MENDS) trial were assessed daily for @entity6 using the Confusion Assessment Method-ICU. Plasma levels of @entity8 and @entity7 were obtained within 24 hours of enrollment. Proportional odds logistic regression was used to examine the association between @entity8 and @entity7 separately with @entity6 / @entity5 -free days, adjusting for age, acute physiology score (APS) of the Acute Physiology And Chronic Health Evaluation (APACHE) II, sedation group ( @entity11 vs. @entity9 ), and @entity4 . Secondary analyses examined the association of these markers with other organ dysfunctions and 28-day survival. RESULTS: Eighty-seven @entity0 were included in this analysis. The median age of the @entity0 was 60 years with APACHE II scores of 28; 68% had @entity4 within 48 hours of admission. Higher levels of @entity8 were associated with fewer @entity6 / @entity5 -free days [odds ratio (OR), 0.5; 95% confidence interval (CI), 0.3 to 1.0; P = 0.04], whereas higher @entity7 levels showed trends towards fewer @entity6 / @entity5 -free days (OR, 0.6; 95% CI, 0.3 to 1.1; P = 0.08). Similar relationships were found regardless of the presence of @entity4 . No associations were found between @entity8 or @entity7 with 28-day survival (P = 0.40 and 0.16, respectively). CONCLUSIONS: In our pilot study, high baseline inflammatory biomarkers predicted prolonged periods of acute @entity3 , implicating @entity1 as an important mechanism in the pathophysiology of @entity6 and @entity5 during @entity10 , irrespective of whether @entity0 had @entity4 or not.

title: @entity8 and @entity7 levels at admission as predictors of duration of acute XXXX in @entity10 @entity0 .

answer: @entity3


abstract: INTRODUCTION: Non-intensive care unit (ICU) cohorts have shown an association between inflammatory disturbances and @entity6 , though these relationships have not been studied in @entity10 @entity0 . This study sought to investigate the relationship between two inflammatory biomarkers, @entity8 and @entity7 ( @entity7 ), and duration of acute @entity3 in ventilated @entity0 . METHODS: @entity0 enrolled in the Maximizing Efficacy of Targeted Sedation and Reducing @entity2 (MENDS) trial were assessed daily for @entity6 using the Confusion Assessment Method-ICU. Plasma levels of @entity8 and @entity7 were obtained within 24 hours of enrollment. Proportional odds logistic regression was used to examine the association between @entity8 and @entity7 separately with @entity6 / @entity5 -free days, adjusting for age, acute physiology score (APS) of the Acute Physiology And Chronic Health Evaluation (APACHE) II, sedation group ( @entity11 vs. @entity9 ), and @entity4 . Secondary analyses examined the association of these markers with other organ dysfunctions and 28-day survival. RESULTS: Eighty-seven @entity0 were included in this analysis. The median age of the @entity0 was 60 years with APACHE II scores of 28; 68% had @entity4 within 48 hours of admission. Higher levels of @entity8 were associated with fewer @entity6 / @entity5 -free days [odds ratio (OR), 0.5; 95% confidence interval (CI), 0.3 to 1.0; P = 0.04], whereas higher @entity7 levels showed trends towards fewer @entity6 / @entity5 -free days (OR, 0.6; 95% CI, 0.3 to 1.1; P = 0.08). Similar relationships were found regardless of the presence of @entity4 . No associations were found between @entity8 or @entity7 with 28-day survival (P = 0.40 and 0.16, respectively). CONCLUSIONS: In our pilot study, high baseline inflammatory biomarkers predicted prolonged periods of acute @entity3 , implicating @entity1 as an important mechanism in the pathophysiology of @entity6 and @entity5 during @entity10 , irrespective of whether @entity0 had @entity4 or not.

title: @entity8 and @entity7 levels at admission as predictors of duration of acute @entity3 in XXXX @entity0 .

answer: @entity10


abstract: INTRODUCTION: Non-intensive care unit (ICU) cohorts have shown an association between inflammatory disturbances and @entity6 , though these relationships have not been studied in @entity10 @entity0 . This study sought to investigate the relationship between two inflammatory biomarkers, @entity8 and @entity7 ( @entity7 ), and duration of acute @entity3 in ventilated @entity0 . METHODS: @entity0 enrolled in the Maximizing Efficacy of Targeted Sedation and Reducing @entity2 (MENDS) trial were assessed daily for @entity6 using the Confusion Assessment Method-ICU. Plasma levels of @entity8 and @entity7 were obtained within 24 hours of enrollment. Proportional odds logistic regression was used to examine the association between @entity8 and @entity7 separately with @entity6 / @entity5 -free days, adjusting for age, acute physiology score (APS) of the Acute Physiology And Chronic Health Evaluation (APACHE) II, sedation group ( @entity11 vs. @entity9 ), and @entity4 . Secondary analyses examined the association of these markers with other organ dysfunctions and 28-day survival. RESULTS: Eighty-seven @entity0 were included in this analysis. The median age of the @entity0 was 60 years with APACHE II scores of 28; 68% had @entity4 within 48 hours of admission. Higher levels of @entity8 were associated with fewer @entity6 / @entity5 -free days [odds ratio (OR), 0.5; 95% confidence interval (CI), 0.3 to 1.0; P = 0.04], whereas higher @entity7 levels showed trends towards fewer @entity6 / @entity5 -free days (OR, 0.6; 95% CI, 0.3 to 1.1; P = 0.08). Similar relationships were found regardless of the presence of @entity4 . No associations were found between @entity8 or @entity7 with 28-day survival (P = 0.40 and 0.16, respectively). CONCLUSIONS: In our pilot study, high baseline inflammatory biomarkers predicted prolonged periods of acute @entity3 , implicating @entity1 as an important mechanism in the pathophysiology of @entity6 and @entity5 during @entity10 , irrespective of whether @entity0 had @entity4 or not.

title: @entity8 and XXXX levels at admission as predictors of duration of acute @entity3 in @entity10 @entity0 .

answer: @entity7


abstract: INTRODUCTION: Non-intensive care unit (ICU) cohorts have shown an association between inflammatory disturbances and @entity6 , though these relationships have not been studied in @entity10 @entity0 . This study sought to investigate the relationship between two inflammatory biomarkers, @entity8 and @entity7 ( @entity7 ), and duration of acute @entity3 in ventilated @entity0 . METHODS: @entity0 enrolled in the Maximizing Efficacy of Targeted Sedation and Reducing @entity2 (MENDS) trial were assessed daily for @entity6 using the Confusion Assessment Method-ICU. Plasma levels of @entity8 and @entity7 were obtained within 24 hours of enrollment. Proportional odds logistic regression was used to examine the association between @entity8 and @entity7 separately with @entity6 / @entity5 -free days, adjusting for age, acute physiology score (APS) of the Acute Physiology And Chronic Health Evaluation (APACHE) II, sedation group ( @entity11 vs. @entity9 ), and @entity4 . Secondary analyses examined the association of these markers with other organ dysfunctions and 28-day survival. RESULTS: Eighty-seven @entity0 were included in this analysis. The median age of the @entity0 was 60 years with APACHE II scores of 28; 68% had @entity4 within 48 hours of admission. Higher levels of @entity8 were associated with fewer @entity6 / @entity5 -free days [odds ratio (OR), 0.5; 95% confidence interval (CI), 0.3 to 1.0; P = 0.04], whereas higher @entity7 levels showed trends towards fewer @entity6 / @entity5 -free days (OR, 0.6; 95% CI, 0.3 to 1.1; P = 0.08). Similar relationships were found regardless of the presence of @entity4 . No associations were found between @entity8 or @entity7 with 28-day survival (P = 0.40 and 0.16, respectively). CONCLUSIONS: In our pilot study, high baseline inflammatory biomarkers predicted prolonged periods of acute @entity3 , implicating @entity1 as an important mechanism in the pathophysiology of @entity6 and @entity5 during @entity10 , irrespective of whether @entity0 had @entity4 or not.

title: @entity8 and @entity7 levels at admission as predictors of duration of acute @entity3 in @entity10 XXXX .

answer: @entity0


abstract: OBJECTIVE: To review the current research of new emerging diagnostic technology for non-invasive physiological monitoring of exercise and @entity2 . As a personal trainer, I believe that exercise can improve the conditions of several diseases and/or events such as @entity1 , post-traumatic @entity3 , @entity4 , and a multitude of other diseases. This compilation of information will allow health care providers tools of a non-invasive manner to promote healing and health that go beyond the initial event. Allowing @entity0 continued managed care beyond what is believed to be their plateau. MATERIAL AND METHOD: Review science-based research involving non-invasive technology, including cardiovascular evaluations: heart rate monitors, near-infrared spectroscopy, blood pressure, and electrocardiography; motor capabilities: surface electromyography and manual testers, i.e. dynamometer, and digital and video photography; radiological monitoring: magnetic resonance imaging, three-dimensional computer tomography, and laser Doppler. RESULTS: This investigation has found that a new approach should be implemented for non-invasive physiological monitoring of exercise and @entity2 through development and utilization across a wide variety of equipment, and monitoring technology. This non-invasive methodology will not only motivate but encourage individuals to begin and remain compliant with an exercise program allowing a variety of health care providers to assist in @entity0 care. DISCUSSION: We need to shift the paradigm from taking care of the sick to maintaining the health of our @entity0 . This can be accomplished with non-invasive evaluation, tracking, and monitoring tools. Many of the suggestions for monitoring are used in a clinical setting rather than a general @entity2 environment. These monitoring tests need to be economical as well as available for continual re-evaluation.

title: Non-invasive physiological monitoring of exercise and XXXX .

answer: @entity2


abstract: OBJECTIVE: To search for predictors of placebo response in clinical trials of @entity3 for the treatment of DSM-IV-TR-defined @entity1 ( @entity1 ) in @entity0 and adults. METHOD: We used data from 2 clinical trials: (1) a 4-week, phase 3, multicenter, randomized, double-blind, forced-dose, parallel-group study of @entity0 aged 6 to 12 years with @entity1 (n = 290) and (2) a 4-week, randomized, double-blind, placebo-controlled, parallel-group, forced-dose titration study in adult subjects, aged 18-55 years with @entity1 (n = 420). Response and remission were defined using the @entity1 Rating Scale-IV and the Clinical Global Impressions-Improvement scale. RESULTS: Symptom remission was inversely correlated with baseline severity in both @entity0 and adults (P < .001), with less robust effects seen for response. The time to response and remission was delayed in adult subjects prescribed placebo versus @entity3 , while response time in @entity0 was also significantly slower with placebo versus @entity3 (P < .01). We found little evidence that demographic factors, prior pharmacotherapy, the emergence of adverse events during the trial, or changes in @entity1 symptoms from the screening to baseline assessments predicted placebo response. Certain comorbid medical symptoms reduced the response and remission rates to placebo in @entity0 (P < .001) and adults (P < .001). CONCLUSIONS: In both @entity0 and adults, baseline symptom severity was the most consistent predictor of remission with placebo while the temporal profile of response reliably differentiated placebo from medication responders. Placebo effects are most likely to be minimized in shorter trials enrolling more severely impaired subjects. The impact of medical and @entity2 comorbidities on placebo response merits further investigation. TRIAL REGISTRATION: clinicaltrials.gov identifiers NCT00556296 and NCT00334880.

title: Prediction of placebo response in 2 clinical trials of @entity3 for the treatment of XXXX .

answer: @entity1