abstract: UNASSIGNED: The new 2010 ACR/EULAR (American College of Rheumatology/European League Against @entity3 ) criteria of @entity1 recently published, have been released to classify and identify @entity0 with early RA who could benefit from early therapy. They recommend anti-citrullinated protein antibody ( @entity4 ) testing as an alternative criterion to Rheumatoid Factor (RF) and @entity4 that were introduced together with the other classic criteria in a scoring system. We previously criticized these new criteria because of unavailable specificity and sensibility in the first paper, and the use of @entity4 as dichotomous criterion (presence/absent) and alternatives to rheumatoid factor. Our previous work promoted discussion and fostered new research on this issue. By the light of new data, in an effort to improve clinical reasoning, we suggest a more practical probabilistic point of view. In this regard, we analyze the sensitivity and specificity of the diagnostic studies that evaluate the performance of the 2010 classification criteria. Then, we compare the old and the new classification criteria. Subsequently, we describe the use of likelihood ratios applied to the classification criteria and different cutoff levels of @entity4 for decision-making in different setting. Moreover, we define some properties of likelihood ratios and their use for diagnosing or excluding @entity1 . We want to share this kind of knowledge within the scientific community because we believe that it can help general practitioners and specialists to recognize early @entity2 @entity0 implementing a more efficient probabilistic clinical reasoning.

title: The challenge of using the XXXX diagnostic criteria in clinical practice.

answer: @entity1


abstract: UNASSIGNED: We wished to evaluate the effects of @entity2 on the morphology and anatomy of @entity3 , Raphanus sativus, @entity4 , @entity3 . capitata and @entity3 . italica. Seeds were subjected to concentrations 0  M, 250  M, 350  M and 450  M @entity2 in the form of @entity5 ( @entity5 ) during 12 days. All species accumulated more @entity2 in the roots than in the shoots, except for @entity3 . capitata. There was no difference of translocation factor between species and treatments. Growth decrease was observed in roots of @entity3 and R. sativus, and in shoots of R. sativus and @entity3 . italica. All species presented anatomical alterations in the roots, such as: cell @entity1 , protoplast retraction, cellular plasmolysis, and @entity0 regions. @entity4 presented collapse and @entity1 of cells from the leaf blade tissues. Quantitative anatomical analyses performed on the root and leaves of @entity3 and @entity4 revealed that @entity2 interfered on the root vascular cylinder diameter and on height of epidermal cells of the adaxial leaf surface of both species. We concluded that @entity2 was absorbed from the culture medium and induced alterations both on root and shoot growth of the seedlings. Retention of @entity2 within the root was responsible for major damage in this organ.

title: XXXX accumulation in Brassicaceae seedlings and its effects on growth and plant anatomy.

answer: @entity2


abstract: BACKGROUND: There is no consensus regarding prophylactic central lymph node dissection (pCLND) in @entity0 with @entity3 ( @entity3 ). Identification of risk factors for central @entity2 (CLNM) in @entity0 with @entity3 could assist surgeons in determining whether to perform selective pCLND. METHODS: The National @entity1 database was queried from 1998 to 2011 for @entity0 with clinical staging T1-4cN0M0 @entity3 . All @entity0 underwent near, sub-, or total thyroidectomy with or without pCLND. Univariate and multivariable logistic regressions were performed on the following clinical variables: age, sex, race and @entity1 size as risk factors for pathologic CLNM (pN1a). RESULTS: In 39,562 @entity0 with T1-4cN0M0 @entity3 , 61% underwent pCLND. @entity0 with age >45  years, African American race, @entity1 size  <=1  cm, unifocal @entity1 , follicular variant @entity3 , no insurance, and treatment at @entity1 facilities were less likely to have pCLND (P  <  .001). In the pCLND group, 15.6% of @entity0 had CLNM. On adjusted multivariable logistic regression, age  <=45  years, Asian race, male sex, and larger @entity1 were statistically significantly associated with CLNM. CONCLUSION: Age  <=45  years, Asian race, male sex, and larger @entity1 are associated with the presence of CLNM, which allows for selective pCLND in @entity3 .

title: Risk factors for central XXXX in @entity3 : A National @entity1 Data Base (NCDB) study.

answer: @entity2


abstract: BACKGROUND: There is no consensus regarding prophylactic central lymph node dissection (pCLND) in @entity0 with @entity3 ( @entity3 ). Identification of risk factors for central @entity2 (CLNM) in @entity0 with @entity3 could assist surgeons in determining whether to perform selective pCLND. METHODS: The National @entity1 database was queried from 1998 to 2011 for @entity0 with clinical staging T1-4cN0M0 @entity3 . All @entity0 underwent near, sub-, or total thyroidectomy with or without pCLND. Univariate and multivariable logistic regressions were performed on the following clinical variables: age, sex, race and @entity1 size as risk factors for pathologic CLNM (pN1a). RESULTS: In 39,562 @entity0 with T1-4cN0M0 @entity3 , 61% underwent pCLND. @entity0 with age >45  years, African American race, @entity1 size  <=1  cm, unifocal @entity1 , follicular variant @entity3 , no insurance, and treatment at @entity1 facilities were less likely to have pCLND (P  <  .001). In the pCLND group, 15.6% of @entity0 had CLNM. On adjusted multivariable logistic regression, age  <=45  years, Asian race, male sex, and larger @entity1 were statistically significantly associated with CLNM. CONCLUSION: Age  <=45  years, Asian race, male sex, and larger @entity1 are associated with the presence of CLNM, which allows for selective pCLND in @entity3 .

title: Risk factors for central @entity2 in XXXX : A National @entity1 Data Base (NCDB) study.

answer: @entity3


abstract: BACKGROUND: There is no consensus regarding prophylactic central lymph node dissection (pCLND) in @entity0 with @entity3 ( @entity3 ). Identification of risk factors for central @entity2 (CLNM) in @entity0 with @entity3 could assist surgeons in determining whether to perform selective pCLND. METHODS: The National @entity1 database was queried from 1998 to 2011 for @entity0 with clinical staging T1-4cN0M0 @entity3 . All @entity0 underwent near, sub-, or total thyroidectomy with or without pCLND. Univariate and multivariable logistic regressions were performed on the following clinical variables: age, sex, race and @entity1 size as risk factors for pathologic CLNM (pN1a). RESULTS: In 39,562 @entity0 with T1-4cN0M0 @entity3 , 61% underwent pCLND. @entity0 with age >45  years, African American race, @entity1 size  <=1  cm, unifocal @entity1 , follicular variant @entity3 , no insurance, and treatment at @entity1 facilities were less likely to have pCLND (P  <  .001). In the pCLND group, 15.6% of @entity0 had CLNM. On adjusted multivariable logistic regression, age  <=45  years, Asian race, male sex, and larger @entity1 were statistically significantly associated with CLNM. CONCLUSION: Age  <=45  years, Asian race, male sex, and larger @entity1 are associated with the presence of CLNM, which allows for selective pCLND in @entity3 .

title: Risk factors for central @entity2 in @entity3 : A National XXXX Data Base (NCDB) study.

answer: @entity1


abstract: PURPOSE: The follow-up of treated @entity2 ( @entity2 ) requires the evaluation of subtle clinical changes and MRI results. When the result is inconclusive, additional procedures are required to assist decision-making, such as the use of advanced MRI (aMRI) sequences and nuclear medicine scans (SPECT and PET). The aim of this study was to determine whether incorporating @entity3 PET/CT in the follow-up protocol for treated @entity2 improves diagnostic accuracy and clinical utility. METHODS: This was a prospective case-series study in @entity0 with treated @entity2 during standard follow-up with indeterminate clinical and/or radiological findings of @entity1 activity. All @entity0 underwent clinical evaluation, aMRI, (201)Tl-SPECT and @entity3 PET/CT. Images were interpreted by visual evaluation complemented with semiquantitative analysis. RESULTS: Between January 2012 and December 2013, 18 @entity0 were included in this study. The final diagnosis was established by histology (five surgical specimens, one biopsy specimen) or by consensus of the Neuro-Oncology Group (11 @entity0 ) after a follow-up of >6  months (mean 14.9        2.72  months). The global diagnostic accuracies were 90.9  % for aMRI (38.8  % inconclusive), 69.2  % for (201)Tl-SPECT (11.1  % inconclusive), and 100  % for @entity3 PET/CT. (201)Tl-SPECT led correctly to a change in the initial approach in 38.9  % of @entity0 but might have led to error in 27.8  %. The use of @entity3 PET/CT alone rather than (201)Tl-SPECT led correctly to a change in the approach suggested by routine follow-up in 72.2  % of @entity0 and endorsed the approach in the remaining 27.8  %. CONCLUSION: Our results support the need to complement structural MRI with aMRI and nuclear medicine procedures in selected @entity0 . @entity3 PET/CT can be useful in the individualized management of @entity0 with treated @entity2 with uncertain clinical and/or radiological evidence of @entity1 activity.

title: XXXX PET/CT as a complementary tool in the follow-up of @entity2 : diagnostic accuracy and clinical utility.

answer: @entity3


abstract: PURPOSE: The follow-up of treated @entity2 ( @entity2 ) requires the evaluation of subtle clinical changes and MRI results. When the result is inconclusive, additional procedures are required to assist decision-making, such as the use of advanced MRI (aMRI) sequences and nuclear medicine scans (SPECT and PET). The aim of this study was to determine whether incorporating @entity3 PET/CT in the follow-up protocol for treated @entity2 improves diagnostic accuracy and clinical utility. METHODS: This was a prospective case-series study in @entity0 with treated @entity2 during standard follow-up with indeterminate clinical and/or radiological findings of @entity1 activity. All @entity0 underwent clinical evaluation, aMRI, (201)Tl-SPECT and @entity3 PET/CT. Images were interpreted by visual evaluation complemented with semiquantitative analysis. RESULTS: Between January 2012 and December 2013, 18 @entity0 were included in this study. The final diagnosis was established by histology (five surgical specimens, one biopsy specimen) or by consensus of the Neuro-Oncology Group (11 @entity0 ) after a follow-up of >6  months (mean 14.9        2.72  months). The global diagnostic accuracies were 90.9  % for aMRI (38.8  % inconclusive), 69.2  % for (201)Tl-SPECT (11.1  % inconclusive), and 100  % for @entity3 PET/CT. (201)Tl-SPECT led correctly to a change in the initial approach in 38.9  % of @entity0 but might have led to error in 27.8  %. The use of @entity3 PET/CT alone rather than (201)Tl-SPECT led correctly to a change in the approach suggested by routine follow-up in 72.2  % of @entity0 and endorsed the approach in the remaining 27.8  %. CONCLUSION: Our results support the need to complement structural MRI with aMRI and nuclear medicine procedures in selected @entity0 . @entity3 PET/CT can be useful in the individualized management of @entity0 with treated @entity2 with uncertain clinical and/or radiological evidence of @entity1 activity.

title: @entity3 PET/CT as a complementary tool in the follow-up of XXXX : diagnostic accuracy and clinical utility.

answer: @entity2


abstract: BACKGROUND: Chronic liver parenchymal diseases as well as @entity8 are established risk factors for @entity10 after partial hepatectomy. As hepatocellular (HCC) and cholangiocellular (CCC) @entity4 often require extended resection due to the often considerable size of @entity1 - in an often priorly damaged liver - surgery for these entities is usually demanding. Due to the lack of potent systemic treatment for primary @entity3 , surgery remains the only potentially curative treatment option for CCC and most HCC; therefore, perioperative risk factors for @entity10 should be reduced as far as possible. OBJECTIVES: In this study measures for reducing the risk of @entity10 after extended liver resections were analyzed. METHODS: This analysis was based on a selective literature search in the Pubmed databank. RESULTS: Medical measures can be used to lower the degree of @entity9 or the inflammatory reaction of @entity2 /reperfusion injury. In particular, biliary decompression should be achieved in @entity11 prior to liver surgery, e.g. for @entity5 , as @entity6 . Moreover, the future liver remnant volume after extended liver resection can be increased by embolization (PVE) or ligation of major branches of the portal vein. Similar results as for PVE regarding liver @entity7 have been reported from unilateral selective internal radiotherapy (SIRT) although this effect appears prolonged and less impressive than after PVE. In addition, two-stage concepts for liver surgery, which are also based on the regenerative potential of the liver, may lower the complication rate and increase @entity0 safety by increasing liver volume. However, conventional two-stage procedures harbor the risk of disease progression during the time lapse to the second step which contraindicates complete resection in 20-30   % of @entity0 . In contrast to this, a complete @entity1 resection is possible in nearly all @entity0 treated by the associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure but long-term results regarding @entity1 recurrence rate are scarce due to the limited experience with this novel technique. CONCLUSION: The perioperative risks of extended liver resection can be lowered by technical and medical measures.

title: [Primary XXXX : Preoperative conditioning of the liver and perioperative management in extended liver resection].

answer: @entity3


abstract: OBJECTIVE: To evaluate the preoperative prevalence of each type of J-wave syndrome electrocardiographic pattern and its association with perioperative @entity1 . DESIGN: Retrospective study. SETTING: Single hospital university study. @entity0 : The study evaluated 930 @entity0 who underwent gynecologic, abdominal, neurosurgical, orthopedic, and urologic surgeries. INTERVENTIONS: Preoperative standard 12-lead electrocardiogram (ECG) monitoring was performed, and each type of J-wave syndrome ECG pattern-types 1, 2, and 3 and Brugada syndrome-type-was evaluated. Incidence of perioperative @entity1 was investigated up to 1 year postoperatively using an electronic medical record system. MEASUREMENTS AND MAIN RESULTS: Data from 789 @entity0 were included in the final study. Of these, 16 @entity0 (2.0%) had J-wave syndrome: 7 @entity0 (0.9%) had type-1 patterns; 5 @entity0 (0.6%) had type-2 patterns; 2 @entity0 (0.3%) had type-3 patterns; and 2 @entity0 (0.3%) had @entity3 patterns. A J-point elevation>= 0.2 mV, which is considered to be more dangerous, was found in only 2 @entity0 with @entity3 patterns, both of whom suffered perioperative @entity2 . CONCLUSION: @entity0 with J-wave syndrome ECG patterns, even dangerous patterns, are not necessarily associated with a higher risk of perioperative @entity1 . However, @entity3 patterns should be carefully monitored.

title: Preoperative Prevalence of J-Wave Syndrome Electrocardiographic Patterns and Their Association With Perioperative XXXX .

answer: @entity1


abstract: PURPOSE: To study the incidence and risk factors for retinal pigment epithelium tears following intravitreal @entity1 ( @entity1 ) injections. METHODS: Retrospective longitudinal study. 4027 intravitreal anti- @entity1 injections in 628 @entity0 (676 eyes) for @entity3 associated with age related @entity2 in a period of 18 months were studied. RESULTS: Seventeen @entity0 (mean age 83.95  5.84) developed retinal pigment epithelium tears. The incidence rate was 0.4%. Fibrovascular pigment epithelium detachment (PED) was previously observed in all cases. In 88 % (15/17) of @entity4 @entity0 that had a RPE tear, PED height was found to be less than 400 microns at presentation. In 5 of 7 @entity0 with RPE tear grade <4, continuing of anti- @entity1 treatment resulted to improvement of visual acuity. CONCLUSION: Critical risk factors for RPE tears are presence of PED as well as advanced age. Visual improvement appears to depend more on the extent and location of the RPE tear and less on the PED height.

title: Incidence of Retinal Pigment Epithelial Tears and Associated Risk Factors After Treatment of Age-Related @entity2 with Intravitreal Anti- XXXX Injections.

answer: @entity1


abstract: PURPOSE: To study the incidence and risk factors for retinal pigment epithelium tears following intravitreal @entity1 ( @entity1 ) injections. METHODS: Retrospective longitudinal study. 4027 intravitreal anti- @entity1 injections in 628 @entity0 (676 eyes) for @entity3 associated with age related @entity2 in a period of 18 months were studied. RESULTS: Seventeen @entity0 (mean age 83.95  5.84) developed retinal pigment epithelium tears. The incidence rate was 0.4%. Fibrovascular pigment epithelium detachment (PED) was previously observed in all cases. In 88 % (15/17) of @entity4 @entity0 that had a RPE tear, PED height was found to be less than 400 microns at presentation. In 5 of 7 @entity0 with RPE tear grade <4, continuing of anti- @entity1 treatment resulted to improvement of visual acuity. CONCLUSION: Critical risk factors for RPE tears are presence of PED as well as advanced age. Visual improvement appears to depend more on the extent and location of the RPE tear and less on the PED height.

title: Incidence of Retinal Pigment Epithelial Tears and Associated Risk Factors After Treatment of Age-Related XXXX with Intravitreal Anti- @entity1 Injections.

answer: @entity2


abstract: OBJECTIVE: LGGs (low-grade @entity3 ) are sometimes encountered by chance during radiological examinations. These incidentally discovered LGGs (IDLGGs) were relatively under-studied in the literature. The purpose of current study is to review a cohort of @entity0 with IDLGGs surgically treated in our institution for their clinical and histological aspects and determine their @entity7 and 1p19q status. METHODS: All @entity0 with hemispheric LGGs receiving operation in our institution between 2001 and 2004 were reviewed. Clinical, radiological and treatment data of the @entity0 were collected and IDLGGs were retrieved and compared with symptomatic LGGs. Histological review was carried out and @entity5 -fixed paraffin embedded (FFPE) tissues of IDLGGs were examined for @entity7 / @entity10 mutation and 1p/19q codeletion. RESULTS: Twenty three IDLGGs (10.4%) were identified while 196 @entity0 had symptomatic LGGs. The reasons for @entity0 with IDLGGs having radiological examination included @entity4 (47.8%), @entity8 (26.1%), unrelated @entity2 (21.7%), and health checkup (4.4%). Clinically, @entity0 with IDLGGs had higher preoperative KPS (P < 0.001), smaller @entity1 volume (P = 0.014), lower frequency of eloquent areas involvement (P < 0.001) and higher rate of complete resection (P = 0.037) comparing to those with symptomatic LGGs. Histologically, there is a preponderance of @entity9 and 11 oligoastrocytomas but there were also 6 @entity6 . @entity7 mutation and 1p/19q co-deletion were detected in 95.7% (22/23) and 69.6% (16/23) of IDLGGs, respectively. The latter encompassed all but one of the cases of @entity1 . @entity0 with IDLGGs had longer overall survival than those with symptomatic LGGs (P = 0.027). CONCLUSIONS: We conclude that the majority of IDLGGs are @entity7 mutated and are predominantly @entity1 . With a median follow-up of 9.3 years to our series, we conclude that @entity0 with IDLGGs had better prognosis than those with symptomatic LGGs. The favorable prognosis of IDLGGs may be accounted by the higher practicability of extensive resection, non-eloquent @entity1 location and smaller @entity1 volume. Frequent @entity7 mutation and 1p/19q co-deletion in IDLGGs may also contribute to the favorable prognosis of this subgroup of @entity0 .

title: Surgically treated incidentally discovered low-grade @entity3 are mostly XXXX mutated and 1p19q co-deleted with favorable prognosis.

answer: @entity7


abstract: OBJECTIVE: LGGs (low-grade @entity3 ) are sometimes encountered by chance during radiological examinations. These incidentally discovered LGGs (IDLGGs) were relatively under-studied in the literature. The purpose of current study is to review a cohort of @entity0 with IDLGGs surgically treated in our institution for their clinical and histological aspects and determine their @entity7 and 1p19q status. METHODS: All @entity0 with hemispheric LGGs receiving operation in our institution between 2001 and 2004 were reviewed. Clinical, radiological and treatment data of the @entity0 were collected and IDLGGs were retrieved and compared with symptomatic LGGs. Histological review was carried out and @entity5 -fixed paraffin embedded (FFPE) tissues of IDLGGs were examined for @entity7 / @entity10 mutation and 1p/19q codeletion. RESULTS: Twenty three IDLGGs (10.4%) were identified while 196 @entity0 had symptomatic LGGs. The reasons for @entity0 with IDLGGs having radiological examination included @entity4 (47.8%), @entity8 (26.1%), unrelated @entity2 (21.7%), and health checkup (4.4%). Clinically, @entity0 with IDLGGs had higher preoperative KPS (P < 0.001), smaller @entity1 volume (P = 0.014), lower frequency of eloquent areas involvement (P < 0.001) and higher rate of complete resection (P = 0.037) comparing to those with symptomatic LGGs. Histologically, there is a preponderance of @entity9 and 11 oligoastrocytomas but there were also 6 @entity6 . @entity7 mutation and 1p/19q co-deletion were detected in 95.7% (22/23) and 69.6% (16/23) of IDLGGs, respectively. The latter encompassed all but one of the cases of @entity1 . @entity0 with IDLGGs had longer overall survival than those with symptomatic LGGs (P = 0.027). CONCLUSIONS: We conclude that the majority of IDLGGs are @entity7 mutated and are predominantly @entity1 . With a median follow-up of 9.3 years to our series, we conclude that @entity0 with IDLGGs had better prognosis than those with symptomatic LGGs. The favorable prognosis of IDLGGs may be accounted by the higher practicability of extensive resection, non-eloquent @entity1 location and smaller @entity1 volume. Frequent @entity7 mutation and 1p/19q co-deletion in IDLGGs may also contribute to the favorable prognosis of this subgroup of @entity0 .

title: Surgically treated incidentally discovered low-grade XXXX are mostly @entity7 mutated and 1p19q co-deleted with favorable prognosis.

answer: @entity3


abstract: @entity2 represent a small proportion of @entity4 , but their incidence has been recently increasing. Most @entity2 are identified incidentally, causing a dilemma for both clinicians and @entity0 . In contrast to @entity3 , neoplastic @entity2 may be cured by resection. In general, @entity2 are classified as neoplastic or non- @entity1 . The predominant types of @entity1 include @entity6 , mucinous @entity1 , @entity9 , and solid @entity1 . With the exception of serous type, @entity1 , have malignant potential, and in most cases requires resection. Non- @entity1 include @entity8 , @entity7 , benign epithelial cysts, @entity2 , squamous lined cysts ( @entity2 in intrapancreatic accessory spleen), mucinous @entity2 , and @entity5 . The incidence of nonneoplastic, noninflammatory cysts is about 6.3% of all @entity2 . Despite the use of high-resolution imaging technologies and cytologic tissue acquisition with endosonography, distinguishing nonneoplastic from @entity1 remains difficult with most differentiations made postoperatively. Nonetheless, the definitive distinction between non-neoplastic and @entity1 is crucial as unnecessary surgery could be avoided with proper diagnosis. Therefore, consideration of these rare disease entities should be entertained before deciding on surgery.

title: Rare XXXX of pancreas.

answer: @entity2


abstract: UNASSIGNED: Dissolved organic matter is established as one of the most relevant photosensitizers in aquatic environments, producing singlet @entity0 ( @entity1 ) alongside other photochemically produced reactive intermediates. While the production of @entity1 from DOM has been well studied, the relative importance of particulate organic matter (POM) to the overall @entity1 production is less well understood. POM is known to play an important role in pollutant fate through the sorption and transport of hydrophobic pollutants. If POM is directly involved in @entity1 production, sorbed molecules would be expected to undergo enhanced photodegradation. In this work, synthetic POM was prepared by coating @entity2 particles with commercial humic acid. The photochemical behavior of these POM samples was compared to dissolved commercial humic acids (DOM). Suspended natural sediment was also studied to test the environmental relevance of the synthetic POM model. Synthetic POM particles appear to simulate well the @entity1 -production of suspended sediment. The @entity1 concentrations experienced by POM-sorbed probe molecules was up to 30% higher than experienced by DOM-sorbed ones, even though the aqueous concentration of @entity1 in irradiated POM suspensions was much lower than the analogous DOM solutions. These results were interpreted with a reaction-diffusion model, which suggested that the production rate of @entity1 by POM is lower than DOM, but the loss of @entity1 from the POM-phase is also lower than DOM. Based on the experimental results of this study, calculations were conducted to estimate the impact of removing POM on @entity1 -mediated processes. These calculations indicate that compounds with a log Koc value near 4 will be most affected by removal of POM and that the magnitude of the effect is proportional to the fraction of the total organic matter represented by POM. This study demonstrates that particles can play an important role in the degradation of organic compounds via aquatic photochemistry.

title: Photochemical production of singlet XXXX from particulate organic matter.

answer: @entity0


abstract: PURPOSE OF REVIEW: @entity1 in the rapidly growing elderly population pose a significant challenge to the healthcare community. These injuries are associated with significant morbidity and mortality, and as a result cause a financial burden on the medical system. Although normal decline in physiologic reserve can provide some explanation for these poor outcomes, there is significant room for improvement. This review will summarize recent literature around the evaluation and management of elderly @entity1 @entity0 with a particular focus on those with @entity2 . RECENT FINDINGS: It is becoming increasingly evident that customized evaluation and management of elderly @entity1 @entity0 is a key factor in improving outcomes. Geriatric-specific triage and assessment criteria have been developed and initial results are encouraging. In particular, the use of frailty as an assessment tool in these @entity0 has been shown to be an independent predictor of outcomes. Further, assessment of these tools in elderly @entity1 @entity0 with @entity2 has provided a wealth of information about their use and limitations. SUMMARY: Differentiated, geriatric-specific triaging, assessment and treatment pathways in the care of elderly @entity1 @entity0 will ultimately lead to improvements in outcomes. These improvements have already started to be seen in the realm of orthogeriatrics.

title: Acute XXXX and multiple injuries in the elderly population.

answer: @entity1


abstract: OBJECTIVE: This study aimed to evaluate the impact on perioperative and medium-term oncologic outcomes of the implementation of laparoscopy into a preexisting oncologic setting. METHODS: Data from consecutive 736 @entity0 undergoing surgery for apparent early stage gynecological @entity1 ( @entity3 ) between 2000 and 2011 were reviewed. Complications were graded per the Accordion classification. Survival outcomes within the first 5 years were analyzed using Kaplan-Meier method. RESULTS: Overall, 493 (67%), 162 (22%), and 81 (11%) had surgery for apparent early stage @entity3 . We assisted at an increase of the number of @entity0 undergoing surgery via laparoscopy through the years (from 10% in the years 2000-2003 to 82% in years 2008-2011; P < 0.001 for trend); while the need to perform open surgery decreased dramatically (from 83% to 10%; P < 0.001). Vaginal approach was nearly stable over the years (from 7% to 8%; P = 0.76). A marked reduction in estimated @entity2 , length of hospital stay, blood transfusions as well as grade greater than or equal to 3 postoperative complications over the years was observed (P < 0.001). Surgical radicality assessed lymph nodes count was not influenced by the introduction of laparoscopic approach (P > 0.05). The introduction of laparoscopy did not adversely affect medium-term (within 5 years) survival outcomes of @entity0 undergoing surgery for apparent early stage @entity1 of the endometrium, uterine cervix, and adnexa (P > 0.05 log-rank test). CONCLUSIONS: The introduction of laparoscopy into a preexisting oncologic service allows an improvement of standard of care due to a gain in perioperative results, without detriments of medium-term oncologic outcomes.

title: Improving Standard of Care Through Introduction of Laparoscopy for the Surgical Management of Gynecological XXXX .

answer: @entity1


abstract: The development of an efficient vaccine against high-risk HPV types can reduce the incidence rates of cervical @entity0 by generating anti- @entity0 protective responses. Traditionally, the majority of prophylactic viral vaccines are composed of live, attenuated or inactivated viruses. Among them, the design of an effective and low-cost vaccine is critical. Inactivated vaccines especially heat-killed @entity3 cells have emerged as a promising approach for generating antigen-specific immunotherapy. Recent studies have indicated that @entity3 cell wall components possess adjuvant activities. Moreover, a non-pathogenic protozoan, @entity6 (L.tar) has attracted a great attention as a live candidate vaccine. In current study, immunological and protective efficacy of whole recombinant killed @entity5 and @entity6 expressing @entity4 L1 capsid protein was evaluated in @entity0 @entity1 model. We found that Pichia-L1, L.tar-L1 and Gardasil groups increase the IgG2a/IgG1 ratio, indicating a relative preference for the induction of Th1 immune responses. Furthermore, subcutaneous injection of killed Pichia-L1 generated the significant L1-specific IFN-y immune response as well as the best protective effects in vaccinated @entity1 as compared to killed L.tar-L1, killed @entity5 , killed L.tar and PBS groups. Indeed, whole recombinant @entity6 could not protect @entity1 against C3 @entity0 @entity1 model. These data suggest that Pichia-L1 may be a candidate for the control of @entity2 .

title: Whole recombinant @entity5 expressing HPV16 L1 antigen is superior in inducing protection against @entity0 growth as compared to killed transgenic XXXX .

answer: @entity6


abstract: The development of an efficient vaccine against high-risk HPV types can reduce the incidence rates of cervical @entity0 by generating anti- @entity0 protective responses. Traditionally, the majority of prophylactic viral vaccines are composed of live, attenuated or inactivated viruses. Among them, the design of an effective and low-cost vaccine is critical. Inactivated vaccines especially heat-killed @entity3 cells have emerged as a promising approach for generating antigen-specific immunotherapy. Recent studies have indicated that @entity3 cell wall components possess adjuvant activities. Moreover, a non-pathogenic protozoan, @entity6 (L.tar) has attracted a great attention as a live candidate vaccine. In current study, immunological and protective efficacy of whole recombinant killed @entity5 and @entity6 expressing @entity4 L1 capsid protein was evaluated in @entity0 @entity1 model. We found that Pichia-L1, L.tar-L1 and Gardasil groups increase the IgG2a/IgG1 ratio, indicating a relative preference for the induction of Th1 immune responses. Furthermore, subcutaneous injection of killed Pichia-L1 generated the significant L1-specific IFN-y immune response as well as the best protective effects in vaccinated @entity1 as compared to killed L.tar-L1, killed @entity5 , killed L.tar and PBS groups. Indeed, whole recombinant @entity6 could not protect @entity1 against C3 @entity0 @entity1 model. These data suggest that Pichia-L1 may be a candidate for the control of @entity2 .

title: Whole recombinant @entity5 expressing HPV16 L1 antigen is superior in inducing protection against XXXX growth as compared to killed transgenic @entity6 .

answer: @entity0


abstract: The development of an efficient vaccine against high-risk HPV types can reduce the incidence rates of cervical @entity0 by generating anti- @entity0 protective responses. Traditionally, the majority of prophylactic viral vaccines are composed of live, attenuated or inactivated viruses. Among them, the design of an effective and low-cost vaccine is critical. Inactivated vaccines especially heat-killed @entity3 cells have emerged as a promising approach for generating antigen-specific immunotherapy. Recent studies have indicated that @entity3 cell wall components possess adjuvant activities. Moreover, a non-pathogenic protozoan, @entity6 (L.tar) has attracted a great attention as a live candidate vaccine. In current study, immunological and protective efficacy of whole recombinant killed @entity5 and @entity6 expressing @entity4 L1 capsid protein was evaluated in @entity0 @entity1 model. We found that Pichia-L1, L.tar-L1 and Gardasil groups increase the IgG2a/IgG1 ratio, indicating a relative preference for the induction of Th1 immune responses. Furthermore, subcutaneous injection of killed Pichia-L1 generated the significant L1-specific IFN-y immune response as well as the best protective effects in vaccinated @entity1 as compared to killed L.tar-L1, killed @entity5 , killed L.tar and PBS groups. Indeed, whole recombinant @entity6 could not protect @entity1 against C3 @entity0 @entity1 model. These data suggest that Pichia-L1 may be a candidate for the control of @entity2 .

title: Whole recombinant XXXX expressing HPV16 L1 antigen is superior in inducing protection against @entity0 growth as compared to killed transgenic @entity6 .

answer: @entity5


abstract: BACKGROUND: Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected @entity0 who should be carefully monitored to exclude the persistence of the @entity2 . In a previous study, we demonstrated high accuracy of five serology tests for the screening and diagnosis of @entity3 . Aim of this study is to evaluate the performance of the same five tests for the follow up of @entity0 infected with S. stercoralis. METHODS: Retrospective study on anonymized, cryo-preserved samples available at the Centre for @entity1 (Negrar, Verona, Italy). Samples were collected before and from 3 to 12 months after treatment. The samples were tested with two commercially-available ELISA tests (IVD, Bordier), two techniques based on a recombinant antigen (NIE-ELISA and NIE-LIPS) and one in-house IFAT. The results of each test were evaluated both in relation to the results of fecal examination and to those of a composite reference standard (classifying as positive a sample with positive stools and/or at least three positive serology tests). The associations between the independent variables age and time and the dependent variable value of serological test (for all five tests), were analyzed by linear mixed-effects regression model. RESULTS: A high proportion of samples demonstrated for each test a seroreversion or a relevant decline (optical density/relative light units halved or decrease of at least two titers for IFAT) at follow up, results confirmed by the linear mixed effects model that showed a trend to seroreversion over time for all tests. In particular, IVD-ELISA (almost 90% samples demonstrated relevant decline) and IFAT (almost 87%) had the best performance. Considering only samples with a complete negativization, NIE-ELISA showed the best performance (72.5% seroreversion). CONCLUSIONS: Serology is useful for the follow up of @entity0 infected with S. stercoralis and determining test of cure.

title: Accuracy of five serologic tests for the follow up of XXXX .

answer: @entity2


abstract: BACKGROUND: Traditional diagnostic tests such as skin prick tests (SPT) and specific IgE (slgE) against whole @entity4 extract have low specificity. Consequently, @entity3 to A simplex is overdiagnosed. OBJECTIVE: Our aim was to compare tests used in component-resolved diagnosis. METHODS: We evaluated 34 @entity0 with @entity3 to A simplex, 15 @entity0 with acute @entity2 who were sensitized to A simplex but had no clinical history of @entity3 to A simplex, and 10 @entity0 @entity1 to seafood. SPT, slgE (ELISA and ISAC-I 12), and the basophil activation test (BAT) were performed with A simplex whole extract and the molecular components rAni s 1, rAni s 3, and nPen m 1. Sensitivity and specificity were calculated and compared with different cutoffs. RESULTS: With the A simplex whole extract, SPT, slgE, and BAT yielded specificity values of 72%, 68%, and 70%, respectively, with a cutoff (wheal size) of 11.2 mm, an slgE value of 7.9 kUAIL, and a stimulation index of 1.9. Specificity increased to 100% using the molecular component rAni s 1 with SPT, slgE by ELISA, and ISAC-112. Neither rAni s 3 sensitization nor cross-reactivity with @entity5 m 1 was observed in @entity0 sensitized to A simplex. CONCLUSION: rAni s 1 is recognized by 100% of our @entity0 and is able to distinguish between @entity0 @entity1 to A simplex and @entity0 with acute @entity2 who are sensitized to A simplex but have no clinical history of @entity3 to this parasite.

title: In vivo and in vitro testing with rAni s 1 can facilitate diagnosis of XXXX @entity3 .

answer: @entity4


abstract: BACKGROUND: Traditional diagnostic tests such as skin prick tests (SPT) and specific IgE (slgE) against whole @entity4 extract have low specificity. Consequently, @entity3 to A simplex is overdiagnosed. OBJECTIVE: Our aim was to compare tests used in component-resolved diagnosis. METHODS: We evaluated 34 @entity0 with @entity3 to A simplex, 15 @entity0 with acute @entity2 who were sensitized to A simplex but had no clinical history of @entity3 to A simplex, and 10 @entity0 @entity1 to seafood. SPT, slgE (ELISA and ISAC-I 12), and the basophil activation test (BAT) were performed with A simplex whole extract and the molecular components rAni s 1, rAni s 3, and nPen m 1. Sensitivity and specificity were calculated and compared with different cutoffs. RESULTS: With the A simplex whole extract, SPT, slgE, and BAT yielded specificity values of 72%, 68%, and 70%, respectively, with a cutoff (wheal size) of 11.2 mm, an slgE value of 7.9 kUAIL, and a stimulation index of 1.9. Specificity increased to 100% using the molecular component rAni s 1 with SPT, slgE by ELISA, and ISAC-112. Neither rAni s 3 sensitization nor cross-reactivity with @entity5 m 1 was observed in @entity0 sensitized to A simplex. CONCLUSION: rAni s 1 is recognized by 100% of our @entity0 and is able to distinguish between @entity0 @entity1 to A simplex and @entity0 with acute @entity2 who are sensitized to A simplex but have no clinical history of @entity3 to this parasite.

title: In vivo and in vitro testing with rAni s 1 can facilitate diagnosis of @entity4 XXXX .

answer: @entity3


abstract: PURPOSE:: Evaluate the effectiveness of @entity9 in the management of @entity5 with orbital extension and/or extensive periocular involvement. METHODS:: Retrospective chart review of 6 consecutive @entity0 with biopsy-proven orbital @entity5 and 2 additional @entity0 with extensive @entity5 who were treated with oral @entity9 (150 mg/day) was performed. RESULTS:: Basal cell @entity2 extended in the orbit in 6 of 8 @entity0 (involving orbital bones in 1 @entity0 ), and 2 of 8 @entity0 had extensive periocular involvement (1 with @entity11 ). @entity9 therapy was the only treatment in 6 @entity0 , off-label neoadjuvant in 1 @entity0 , and adjuvant treatment in 1 @entity0 . @entity1 in all 4 @entity0 who received @entity9 as sole treatment showed partial response with a mean 83% shrinkage in @entity1 size after a median of 7 months of therapy. In the 2 @entity0 receiving @entity9 as neoadjuvant or adjuvant therapies, there was complete response after a median of 7 months of therapy and no evidence of clinical recurrence after discontinuing therapy for a median of 15 months. The 2 @entity0 with extensive periocular involvement experienced complete clinical response after a median 14 months of treatment. During treatment, the most common side effects were @entity8 (75%) followed by @entity6 (50%), @entity7 (25%), @entity10 , and episodes of @entity3 and @entity4 (13%). CONCLUSIONS:: Basal cell @entity2 with orbital extension and extensive periocular involvement responds to @entity9 therapy. The long-term prognosis remains unknown, and additional prospective studies are indicated.

title: Efficacy of @entity9 (Erivedge) for XXXX Involving the Orbit and Periocular Area.

answer: @entity5


abstract: PURPOSE:: Evaluate the effectiveness of @entity9 in the management of @entity5 with orbital extension and/or extensive periocular involvement. METHODS:: Retrospective chart review of 6 consecutive @entity0 with biopsy-proven orbital @entity5 and 2 additional @entity0 with extensive @entity5 who were treated with oral @entity9 (150 mg/day) was performed. RESULTS:: Basal cell @entity2 extended in the orbit in 6 of 8 @entity0 (involving orbital bones in 1 @entity0 ), and 2 of 8 @entity0 had extensive periocular involvement (1 with @entity11 ). @entity9 therapy was the only treatment in 6 @entity0 , off-label neoadjuvant in 1 @entity0 , and adjuvant treatment in 1 @entity0 . @entity1 in all 4 @entity0 who received @entity9 as sole treatment showed partial response with a mean 83% shrinkage in @entity1 size after a median of 7 months of therapy. In the 2 @entity0 receiving @entity9 as neoadjuvant or adjuvant therapies, there was complete response after a median of 7 months of therapy and no evidence of clinical recurrence after discontinuing therapy for a median of 15 months. The 2 @entity0 with extensive periocular involvement experienced complete clinical response after a median 14 months of treatment. During treatment, the most common side effects were @entity8 (75%) followed by @entity6 (50%), @entity7 (25%), @entity10 , and episodes of @entity3 and @entity4 (13%). CONCLUSIONS:: Basal cell @entity2 with orbital extension and extensive periocular involvement responds to @entity9 therapy. The long-term prognosis remains unknown, and additional prospective studies are indicated.

title: Efficacy of XXXX (Erivedge) for @entity5 Involving the Orbit and Periocular Area.

answer: @entity9


abstract: UNASSIGNED: Background and purpose Although @entity10 ( @entity10 ) are common causes of @entity5 in young individuals, anatomical locations and mechanisms of @entity5 are still unclear. We evaluate the prevalence, location, and pathogenic mechanisms of @entity5 caused by @entity10 . METHODS: We reviewed CAD @entity0 who presented with acute (<7days) @entity1 events and who had undergone diffusion weighted magnetic resonance imaging (MRI) and appropriate vascular imagings (MR angiography, computed tomography angiography, digital subtraction angiography, and high-resolution MRI). @entity2 mechanisms were categorized as artery-to-artery (AA) @entity8 , @entity7 , in situ @entity6 and @entity3 . RESULTS: One hundred and thirty-five @entity0 with @entity5 (n=125) or transient @entity1 attacks (n=10) were included. The locations of 159 dissected vessels were: 77 vertebral, 29 internal carotid, 24 middle cerebral, 12 basilar, eight posterior inferior cerebellar, five anterior cerebral, and four posterior cerebral arteries. Among @entity2 mechanisms, @entity9 (n=70, 55.5%) was the most common followed by @entity7 (n=40, 31.7%) and in situ @entity6 (n=8, 6.3%). Intracranial @entity10 were more common (89 vs. 44), less often associated with @entity4 (21.3% vs. 40.9%, p=0.018) and @entity9 (32.9% vs. 97.6%, p<0.001), and more often treated with intravenous thrombolysis (15.7% vs. 2.3%. p=0.021) than extracranial @entity10 . CONCLUSIONS: In our cohort, intracranial @entity10 are more common than extracranial @entity10 , and the vertebral artery is the most frequently involved site. Although @entity9 is the main @entity2 mechanism, @entity7 is another important @entity2 mechanism.

title: Intracranial and extracranial arterial dissection presenting with @entity5 : Lesion location and XXXX mechanism.

answer: @entity2


abstract: UNASSIGNED: Background and purpose Although @entity10 ( @entity10 ) are common causes of @entity5 in young individuals, anatomical locations and mechanisms of @entity5 are still unclear. We evaluate the prevalence, location, and pathogenic mechanisms of @entity5 caused by @entity10 . METHODS: We reviewed CAD @entity0 who presented with acute (<7days) @entity1 events and who had undergone diffusion weighted magnetic resonance imaging (MRI) and appropriate vascular imagings (MR angiography, computed tomography angiography, digital subtraction angiography, and high-resolution MRI). @entity2 mechanisms were categorized as artery-to-artery (AA) @entity8 , @entity7 , in situ @entity6 and @entity3 . RESULTS: One hundred and thirty-five @entity0 with @entity5 (n=125) or transient @entity1 attacks (n=10) were included. The locations of 159 dissected vessels were: 77 vertebral, 29 internal carotid, 24 middle cerebral, 12 basilar, eight posterior inferior cerebellar, five anterior cerebral, and four posterior cerebral arteries. Among @entity2 mechanisms, @entity9 (n=70, 55.5%) was the most common followed by @entity7 (n=40, 31.7%) and in situ @entity6 (n=8, 6.3%). Intracranial @entity10 were more common (89 vs. 44), less often associated with @entity4 (21.3% vs. 40.9%, p=0.018) and @entity9 (32.9% vs. 97.6%, p<0.001), and more often treated with intravenous thrombolysis (15.7% vs. 2.3%. p=0.021) than extracranial @entity10 . CONCLUSIONS: In our cohort, intracranial @entity10 are more common than extracranial @entity10 , and the vertebral artery is the most frequently involved site. Although @entity9 is the main @entity2 mechanism, @entity7 is another important @entity2 mechanism.

title: Intracranial and extracranial arterial dissection presenting with XXXX : Lesion location and @entity2 mechanism.

answer: @entity5


abstract: PURPOSE: Recent studies have shown that the risk of cerebro- and cardiovascular events (CVEs) is higher in @entity0 with @entity2 ( @entity2 ) than in those with essential @entity1 (EH), and that silent @entity4 (SBI) is a risk factor and predictor of CVEs. Here, we evaluated the relationship between findings from laser speckle flowgraphy (LSFG), a recently introduced non-invasive means of measuring mean blur rate (MBR), an important biomarker of ocular blood flow, and the occurrence of SBI in @entity0 with @entity2 . METHODS: 87 @entity2 @entity0 without symptomatic cerebral events (mean 55.1    11.2 years old, 48 male and 39 female) were enrolled in this study. We measured MBR in the optic nerve head (ONH) with LSFG and checked the occurrence of SBI with magnetic resonance imaging. We examined three MBR waveform variables: skew, blowout score (BOS) and blowout time (BOT). We also recorded clinical findings, including age, blood pressure, and plasma @entity3 concentration. RESULTS: @entity2 @entity0 with SBI (15 of 87 @entity0 ; 17%) were significantly older and had significantly lower BOT in the capillary area of the ONH than the @entity0 without SBI (P = 0.02 and P = 0.03, respectively). Multiple logistic regression analysis revealed that age and BOT were independent factors for the presence of SBI in @entity2 @entity0 (OR, 1.15, 95% CI 1.01-1.38; P = .03 and OR, 0.73, 95% CI 0.45-0.99; P = .04, respectively). CONCLUSION: @entity2 @entity0 with SBI were older and had lower MBR BOT than those without SBI. Our analysis showed that age was a risk factor for SBI, and that BOT was a protective factor, in @entity0 with @entity2 . This suggests that BOT, a non-invasive and objective biomarker, may be a useful predictor of SBI and form part of future @entity2 evaluations and clinical decision-making.

title: Relationship of ocular microcirculation, measured by laser speckle flowgraphy, and silent @entity4 in XXXX .

answer: @entity2


abstract: PURPOSE: Recent studies have shown that the risk of cerebro- and cardiovascular events (CVEs) is higher in @entity0 with @entity2 ( @entity2 ) than in those with essential @entity1 (EH), and that silent @entity4 (SBI) is a risk factor and predictor of CVEs. Here, we evaluated the relationship between findings from laser speckle flowgraphy (LSFG), a recently introduced non-invasive means of measuring mean blur rate (MBR), an important biomarker of ocular blood flow, and the occurrence of SBI in @entity0 with @entity2 . METHODS: 87 @entity2 @entity0 without symptomatic cerebral events (mean 55.1    11.2 years old, 48 male and 39 female) were enrolled in this study. We measured MBR in the optic nerve head (ONH) with LSFG and checked the occurrence of SBI with magnetic resonance imaging. We examined three MBR waveform variables: skew, blowout score (BOS) and blowout time (BOT). We also recorded clinical findings, including age, blood pressure, and plasma @entity3 concentration. RESULTS: @entity2 @entity0 with SBI (15 of 87 @entity0 ; 17%) were significantly older and had significantly lower BOT in the capillary area of the ONH than the @entity0 without SBI (P = 0.02 and P = 0.03, respectively). Multiple logistic regression analysis revealed that age and BOT were independent factors for the presence of SBI in @entity2 @entity0 (OR, 1.15, 95% CI 1.01-1.38; P = .03 and OR, 0.73, 95% CI 0.45-0.99; P = .04, respectively). CONCLUSION: @entity2 @entity0 with SBI were older and had lower MBR BOT than those without SBI. Our analysis showed that age was a risk factor for SBI, and that BOT was a protective factor, in @entity0 with @entity2 . This suggests that BOT, a non-invasive and objective biomarker, may be a useful predictor of SBI and form part of future @entity2 evaluations and clinical decision-making.

title: Relationship of ocular microcirculation, measured by laser speckle flowgraphy, and silent XXXX in @entity2 .

answer: @entity4


abstract: PROBLEM/OBJECTIVE: We compared the effects of preincisional peritonsillar infiltration of 5 ml @entity5 (50 mg/10 ml) on bleeding during surgery and @entity1 after tonsillectomy in @entity0 aged 16 years or older. METHODOLOGY: The study was conducted in 44 adult @entity0 who underwent tonsillectomy. These @entity0 were randomized to either the study group (SG) who received @entity5 infiltration to the peritonsillary fossae prior to surgery, or a control group (CG) treated with 0.9% @entity6 infiltration to the peritonsillary fossae prior to incision. The volume of @entity4 was recorded. @entity1 was evaluated using a visual analogue scale (VAS). The first @entity1 score was assessed immediately after arriving in the postoperative care unit. VAS scores were subsequently re-assessed 2, 4, 8, 12, and 24 hours postoperatively. The first analgesic requirement was assessed 24 hours postoperatively. RESULTS: The @entity1 relieving effect in the @entity5 group was statistically significant 2, 4, 12, and 24 hours postoperatively (p  <= 0.05), but there was no difference in VAS scores between groups at the first and 8-hour postoperative assessments. There were no differences between the two groups regarding analgesic requirements. The difference between the mean intraoperative @entity2 in the SG and CG was statistically significant (p  <= 0.05). No serious complications were observed in either group. CONCLUSION: Preincisional @entity5 infiltration seems to be a safe and easily applied medication for @entity3 control, and decreased the volume of intraoperative @entity2 in adult @entity0 after tonsillectomy.

title: Efficacy of preincisional XXXX for adult tonsillectomy @entity0 .

answer: @entity5


abstract: PROBLEM/OBJECTIVE: We compared the effects of preincisional peritonsillar infiltration of 5 ml @entity5 (50 mg/10 ml) on bleeding during surgery and @entity1 after tonsillectomy in @entity0 aged 16 years or older. METHODOLOGY: The study was conducted in 44 adult @entity0 who underwent tonsillectomy. These @entity0 were randomized to either the study group (SG) who received @entity5 infiltration to the peritonsillary fossae prior to surgery, or a control group (CG) treated with 0.9% @entity6 infiltration to the peritonsillary fossae prior to incision. The volume of @entity4 was recorded. @entity1 was evaluated using a visual analogue scale (VAS). The first @entity1 score was assessed immediately after arriving in the postoperative care unit. VAS scores were subsequently re-assessed 2, 4, 8, 12, and 24 hours postoperatively. The first analgesic requirement was assessed 24 hours postoperatively. RESULTS: The @entity1 relieving effect in the @entity5 group was statistically significant 2, 4, 12, and 24 hours postoperatively (p  <= 0.05), but there was no difference in VAS scores between groups at the first and 8-hour postoperative assessments. There were no differences between the two groups regarding analgesic requirements. The difference between the mean intraoperative @entity2 in the SG and CG was statistically significant (p  <= 0.05). No serious complications were observed in either group. CONCLUSION: Preincisional @entity5 infiltration seems to be a safe and easily applied medication for @entity3 control, and decreased the volume of intraoperative @entity2 in adult @entity0 after tonsillectomy.

title: Efficacy of preincisional @entity5 for adult tonsillectomy XXXX .

answer: @entity0


abstract: 1. Aldolase isoenzymes from @entity1 cerebral cortex were partially purified and separated by @entity4 fractionation and chromatography on DEAE-cellulose. 2. Each purified isoenzyme was shown to be virtually uncontaminated with other forms by starch-gel electrophoresis. The quantitative distribution of the isoenzymes was: I, 6.2%; II, 5.2%; III, 15.3%; IV, 25.7%; V, 33.3%. 3. The pH optima for the five separated isoenzymes were similar; all were in the range pH7.5-8.0. Values for pK(a) (6.31-6.55) and pK(b) (9.45-9.59) were calculated from the data and suggested the involvement of @entity2 and @entity0 residues. 4. The stabilities of the isoenzymes were shown to be I=II>III>IV>V at pH4.4 in order of decreasing stability and are discussed in terms of subunit structure. 5. The substrate activity ratios ( @entity3 / @entity5 ) were measured and all were in the range 12-44.

title: The separation, prtial purificatio nd some properties of isoenzymes of aldolase from XXXX cerebral cortex.

answer: @entity1


abstract: 1. The conditions affecting the activity of RNA polymerase in isolated @entity0 liver nuclei were studied with @entity3 or @entity4 as activating ions. 2. The enzyme assayed with @entity3 and at low ionic strength is saturated by a lower concentration of @entity1 substrates than if assayed with @entity4 at low ionic strength or with either ion at high ionic strength. 3. At low and at high ionic strength the incorporation of @entity2 is affected in a similar way by variations in the temperature of incubation. Preincubation at 37 degrees impairs the @entity2 incorporation. 4. Heparin stimulates the RNA polymerase activity in the presence of @entity4 . 5. Both @entity5 and heparin ;restart' the reaction if added after 15min., the effect being more marked with @entity5 than with heparin, and also more marked in the presence of @entity4 than of @entity3 . 6. alpha-Amanitin abolishes the effect of @entity5 and of heparin.

title: Experimental conditions affecting ribonucleic acid polymerase in isolated @entity0 liver nuclei. Effect of nucleoside triphosphate concentration, temperature, XXXX and heparin.

answer: @entity5


abstract: 1. The conditions affecting the activity of RNA polymerase in isolated @entity0 liver nuclei were studied with @entity3 or @entity4 as activating ions. 2. The enzyme assayed with @entity3 and at low ionic strength is saturated by a lower concentration of @entity1 substrates than if assayed with @entity4 at low ionic strength or with either ion at high ionic strength. 3. At low and at high ionic strength the incorporation of @entity2 is affected in a similar way by variations in the temperature of incubation. Preincubation at 37 degrees impairs the @entity2 incorporation. 4. Heparin stimulates the RNA polymerase activity in the presence of @entity4 . 5. Both @entity5 and heparin ;restart' the reaction if added after 15min., the effect being more marked with @entity5 than with heparin, and also more marked in the presence of @entity4 than of @entity3 . 6. alpha-Amanitin abolishes the effect of @entity5 and of heparin.

title: Experimental conditions affecting ribonucleic acid polymerase in isolated XXXX liver nuclei. Effect of nucleoside triphosphate concentration, temperature, @entity5 and heparin.

answer: @entity0


abstract: 1. The Valsalva ratios (VR) of 48 @entity1 @entity0 and 48 normal individuals matched by age and sex were compared in order to examine the relationship between VR and the prevalence and severity of @entity5 , @entity3 and @entity2 , which are chronic complications of @entity1 . 2. @entity1 @entity0 without clinical evidence of @entity3 had the same VR (1.95 +/- 0.09) as the matched control group (1.95 +/- 0.14). @entity1 @entity0 exhibiting some evidence of @entity6 showed VR values lower than their control groups (1.58 +/- 0.07 vs. 1.81 +/- 0.7), whereas @entity0 with symmetric sensitive @entity4 plus @entity7 had the lowest VR scores (1.16 +/- 0.04 vs. 1.86 +/- 0.14). 3. An inverse relationship was shown between VR and the prevalence of @entity5 and @entity2 and the duration of @entity1 . Low VR values correlated well with the prevalence and severity of complications. 4. It is concluded that the Valsalva ratio is an effective indicator of @entity7 .

title: Relationship of the Valsalva ratio to XXXX .

answer: @entity3


abstract: The usefulness and limitations of the carcinoembryonic antigen (C.E.A.) radioimmunoassay for the evaluation of @entity1 resection and for the detection of @entity1 relapse were studied in @entity0 with @entity2 . The level of plasma-C.E.A. was determined before any treatment in a group of 101 @entity0 with histologically proven @entity3 and rectum. 71% of all @entity0 and 63% of cases with @entity1 (Dukes A and B) had a preoperative C.E.A. value of 5 ng. per ml. or higher. This limit was reached by only 1 of 90 apparently healthy, non-smoking blood-donors. Among 45 @entity0 for whom a complete @entity1 resection was reported, all @entity0 except 5 showed a drop of C.E.A. to normal values after surgery. The 5 @entity0 whose C.E.A. did not fall to below 5 ng. per ml. showed a subsequent rise in C.E.A. level and were all found later to have a @entity1 relapse. The results indicate that an incomplete drop of circulating C.E.A. level one month after surgery has a bad prognostic significance. 22 of these @entity0 were followed up by repeated C.E.A. radioimmunoassay for several months after surgery. 8 showed a progressive increase in C.E.A. levels preceding clinical diagnosis of @entity1 relapse by two to ten months. 6 other @entity0 showed a moderate increase in C.E.A. levels, suggesting a @entity1 relapse not yet clinically detectable. The remaining 8 @entity0 showed no increase in C.E.A. level above 5 ng. per ml. and no clinical symptoms of relapse. The results demonstrate that relapses of @entity3 can be detected by increased C.E.A. levels months before the appearance of any clinical evidence.

title: Detection of recurrence of XXXX by radioimmunoassay of circulating carcinoembryonic antigen (C.E.A.).

answer: @entity2


abstract: UNASSIGNED: The aetiology and pathological mechanisms involved in the development of haematidrosis (bloody sweat) remain unclear. There is no specific treatment for this disorder. This case report describes the clinical manifestations and treatment of a 9-year-old female with haematidrosis associated with @entity1 . The diagnosis of haematidrosis was confirmed by medical personnel who observed the @entity3 and were able to rule out other causes of the bloody exudate. The episodes of @entity3 were spontaneous, transient, and self-limited. Smears of the bloody exudate contained all of the components of peripheral blood. A skin biopsy taken at one site of the bloody exudate was normal, showing no signs of @entity4 or @entity3 sweat glands. The @entity3 events were found to be immediately preceded by tonic @entity2 . An electroencephalogram indicated cerebral @entity1 , which was characterized by an intermittent medium-high amplitude    rhythm (5-7   Hz) with a few spikes. The symptoms of both @entity1 and haematidrosis resolved after treatment with the antiepileptic drug 150   mg @entity5 , orally, twice a day, which suggests that the @entity1 triggered haematidrosis in this @entity0 .

title: Haematidrosis associated with XXXX in a @entity0 successfully treated with @entity5 : Case report.

answer: @entity1


abstract: UNASSIGNED: The aetiology and pathological mechanisms involved in the development of haematidrosis (bloody sweat) remain unclear. There is no specific treatment for this disorder. This case report describes the clinical manifestations and treatment of a 9-year-old female with haematidrosis associated with @entity1 . The diagnosis of haematidrosis was confirmed by medical personnel who observed the @entity3 and were able to rule out other causes of the bloody exudate. The episodes of @entity3 were spontaneous, transient, and self-limited. Smears of the bloody exudate contained all of the components of peripheral blood. A skin biopsy taken at one site of the bloody exudate was normal, showing no signs of @entity4 or @entity3 sweat glands. The @entity3 events were found to be immediately preceded by tonic @entity2 . An electroencephalogram indicated cerebral @entity1 , which was characterized by an intermittent medium-high amplitude    rhythm (5-7   Hz) with a few spikes. The symptoms of both @entity1 and haematidrosis resolved after treatment with the antiepileptic drug 150   mg @entity5 , orally, twice a day, which suggests that the @entity1 triggered haematidrosis in this @entity0 .

title: Haematidrosis associated with @entity1 in a @entity0 successfully treated with XXXX : Case report.

answer: @entity5


abstract: UNASSIGNED: The aetiology and pathological mechanisms involved in the development of haematidrosis (bloody sweat) remain unclear. There is no specific treatment for this disorder. This case report describes the clinical manifestations and treatment of a 9-year-old female with haematidrosis associated with @entity1 . The diagnosis of haematidrosis was confirmed by medical personnel who observed the @entity3 and were able to rule out other causes of the bloody exudate. The episodes of @entity3 were spontaneous, transient, and self-limited. Smears of the bloody exudate contained all of the components of peripheral blood. A skin biopsy taken at one site of the bloody exudate was normal, showing no signs of @entity4 or @entity3 sweat glands. The @entity3 events were found to be immediately preceded by tonic @entity2 . An electroencephalogram indicated cerebral @entity1 , which was characterized by an intermittent medium-high amplitude    rhythm (5-7   Hz) with a few spikes. The symptoms of both @entity1 and haematidrosis resolved after treatment with the antiepileptic drug 150   mg @entity5 , orally, twice a day, which suggests that the @entity1 triggered haematidrosis in this @entity0 .

title: Haematidrosis associated with @entity1 in a XXXX successfully treated with @entity5 : Case report.

answer: @entity0


abstract: UNASSIGNED: @entity4 is a major destructive collagenase involved in @entity3 and can be regarded as @entity3 biomarker. A neutrophil @entity4 (aMMP-8) oral fluid immunoassay has recently been demonstrated to be a @entity3 risk indicator, among adults. AIM: Our aim was to investigate a chair-side point-of-care mouthrinse test (Periosafe) based on aMMP-8 immunoassay could identify @entity0 with oral inflammatory burden ( @entity3 and @entity2 ) among adolescents with early pathological findings. METHODS: This cross sectional study was carried out at the Kotka Health Center, Finland. First, PerioSafe aMMP-8 chair-side mouthrinse test was performed on enrolled subjects (adolescents aged 15 to 17 year-old, n=47), and the results were read based on a color change within 5 minutes. Then, full-mouth clinical parameters of oral health were assessed including periodontal, oral mucosal and @entity2 status. RESULTS: The sensitivity and specificity of the neutrophil collagenase-2 immunoassay for BOP positives was 71.8 % and specificity 77.5 % (p=0.018), for at least one >=  4 mm deep pocket 48.3 % and 100 % (0<0.0001), at least two >= 4 mm deep pockets 63.6 % and 100 % (p<0.0001), more than two >=  4 mm deep pockets 76.5 % and 96.8 % (p< 0.0001), respectively. Regarding @entity3 (at least one >=  4 mm deep pocket ) hardly any false positive could be identified. The sensitivity of the neutrophil collagenase-2 immunoassay for at least one @entity1 was 76.5 % and specificity 96.7 % (p<0.01). CONCLUSION: PerioSafe aMMP-8 chair side-test analyzing mouthrinse a @entity4 showed promising results in recognition of oral inflammatory burden in adolescents with early initial signs of @entity3 in 5 minutes. @entity1 could also be detected, but less efficiently.

title: A Pilot Study on Oral Health Status as Assessed by an Active XXXX (aMMP-8) Chair-Side Mouthrinse Test in Adolescents.

answer: @entity4


abstract: @entity2 ( @entity2 ) is a heterogeneous group of @entity1 with various clinical features causing diagnostic and therapeutic challenges. The aim of this study was to evaluate the ability of @entity3 FDG PET/CT for localizing the @entity1 , disclosing additional metastases, and changing the treatment in @entity0 with @entity2 . One hundred and twelve metastatic @entity0 (female = 40, male = 72, median age = 60.5 years) in whom conventional diagnostic work-up failed to disclose the @entity1 were included in the study. @entity3 FDG PET/CT imaging was performed in a standard protocol ( @entity0 supine, arms on @entity0 's side, vertex to thigh, 369.3 MBq (296-444 MBq) @entity3 FDG, a 60-minute uptake period, 6-7 bed position). Histopathology was taken as the only reference standard. @entity3 FDG PET/CT correctly detected @entity1 in 37 of 112 (33.03%) @entity0 . The most common site of @entity1 detected by @entity3 FDG PET/CT was lung (n = 18), which was followed by nasopharynx (n = 7), pancreas (n = 5), tonsil (n = 2), breast (n = 2), thyroid (n = 1), uterus (n = 1) and colon/rectum (n = 1). @entity3 FDG PET/CT imaging disclosed additional previously undetected metastases in 32 (28.5%) and changed the treatment in 33 (29.4%) of 112 @entity0 . There were false positive @entity3 FDG PET/CT results in 21 (18.5%) @entity0 . @entity3 FDG PET/CT is able to disclose the @entity1 , disclose new metatases and change the treatment in about one third of @entity0 with @entity2 .

title: Utility of XXXX fluorodeoxyglucose pos  tron em  ss  on tomography/computed   n carc  noma of unknown primary.

answer: @entity3


abstract: Mammary gland analog @entity2 (MASC) of @entity4 is typically a @entity1 of low histologic grade and behaves as a low-grade malignancy with relatively benign course. This @entity1 shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, @entity6 - @entity7 , with @entity2 of breast. Histologically, it is often mistaken as @entity5 , @entity3 not otherwise specified, and other primary @entity1 . Here we report a case of MASC with high-grade transformation and cervical lymph node metastases confirmed with @entity6 - @entity7 translocation arising in the hard palate of a 41 year-old adult. Interestingly, the @entity2 has lower grade than the original @entity1 which strongly support @entity1 . Most commonly, MASC arises from the parotid gland and less often in minor salivary glands. @entity0 is relatively uncommon and high-grade histology has only been reported in four cases with three of them arising from the parotid gland and the location of the fourth one has not been reported. This is the first case with high grade histology that arise from minor @entity4 and it emphasizes the importance of molecular screening of @entity1 with high-grade histology for @entity6 - @entity7 translocation. In our literature of 115 cases that includes the current case, MASC occurred predominantly in adult with only a few cases under 18 years of age and a male to female ratio of 1.2:1. Parotid gland is more commonly affected but there is also significant occurrence in minor salivary glands. Except for the cases with high grade histology, the overall prognosis is good.

title: Mammary analog XXXX of @entity4 with high-grade histology arising in hard palate, report of a case and review of literature.

answer: @entity2


abstract: Mammary gland analog @entity2 (MASC) of @entity4 is typically a @entity1 of low histologic grade and behaves as a low-grade malignancy with relatively benign course. This @entity1 shares histologic features, immunohistochemical profile, and a highly specific genetic translocation, @entity6 - @entity7 , with @entity2 of breast. Histologically, it is often mistaken as @entity5 , @entity3 not otherwise specified, and other primary @entity1 . Here we report a case of MASC with high-grade transformation and cervical lymph node metastases confirmed with @entity6 - @entity7 translocation arising in the hard palate of a 41 year-old adult. Interestingly, the @entity2 has lower grade than the original @entity1 which strongly support @entity1 . Most commonly, MASC arises from the parotid gland and less often in minor salivary glands. @entity0 is relatively uncommon and high-grade histology has only been reported in four cases with three of them arising from the parotid gland and the location of the fourth one has not been reported. This is the first case with high grade histology that arise from minor @entity4 and it emphasizes the importance of molecular screening of @entity1 with high-grade histology for @entity6 - @entity7 translocation. In our literature of 115 cases that includes the current case, MASC occurred predominantly in adult with only a few cases under 18 years of age and a male to female ratio of 1.2:1. Parotid gland is more commonly affected but there is also significant occurrence in minor salivary glands. Except for the cases with high grade histology, the overall prognosis is good.

title: Mammary analog @entity2 of XXXX with high-grade histology arising in hard palate, report of a case and review of literature.

answer: @entity4


abstract: UNASSIGNED: The US Public Health Service has finalized its recommendation relating to community water fluoridation (Federal Panel on Community Water Fluoridation, US Department of Health and @entity0 Services, 2015). It recommends an optimal concentration of 0.7 mg/l F based on their argument that this concentration provides the best balance of protection from dental caries while limiting the risk of dental @entity2 . The rationale for this recommendation can be questioned, particularly given the contrasting etiologies and impact on the community. Uncertainty surrounds the key evidence considered by the panel. This study argues that the panel should have exercised more caution and called for further research before reducing the 'optimal' concentration of @entity1 in water supplies. Up-to-date data on caries and @entity2 trend by age group or birth cohort, analyses on attributable risk for @entity2 , data on individual and population impact of caries and @entity2 , water intake over an extended period across the seasons, and the curvilinear relationship of @entity1 concentration in water supplies and caries protection would have all been desirable to inform the panel, given the foreshadowing of the recommendation in late 2011. Further, a wider range of policy directions to achieve the best balance of protection from dental caries while limiting the risk of dental @entity2 are available from the international literature. Assessment of these should have been more evident. There is a public health policy responsibility to monitor water fluoridation programs so as to achieve a near maximum reduction in dental caries without unacceptable levels of dental @entity2 . However, recommendations to alter existing policy need to be cognizant of the balancing of risk and protective exposures across the entire population and potentially all ages and to be based on recent data that are purposefully collected, critically analyzed and carefully interpreted.

title: Caution needed in altering the 'optimum' XXXX concentration in drinking water.

answer: @entity1


abstract: BACKGROUND: The most widely researched risk/complication following vertebroplasty (VP) or kyphoplasty (KP) is that of @entity4 ( @entity4 ). Current literature results regarding the effect of intradiscal extravasation of cement on the risk of @entity4 is conflicting with about half of the studies concluding there is no added risk with endplate extravasation and half of the studies reporting opposite conclusions. OBJECTIVE: The purpose of the study is to further stratify the data to determine whether specifically the location and extent of endplate cement extravasation more strongly affect @entity4 risk in @entity6 @entity0 following either @entity5 . STUDY DESIGN: Retrospective cohort study. SETTING: University teaching hospitalMETHODS: One hundred and fifty-six cemented levels in 80 @entity0 , treated at a single center between 2008 and 2012 were reviewed. Age, gender, T-score, body mass index, and @entity3 type (primary or secondary) were recorded. An @entity4 was defined as a @entity4 : 1) in a non-cemented vertebra; 2) adjacent to a cemented level; and 3) not due to @entity2 or @entity1 . Location of the cement extravasation (anterior, middle, or posterior third of the vertebral body) and extravasation extent (percentage of the intervertebral disc height occupied by the bolus) were measured. A logistic modeling strategy permitted examining the association between the location and extent of extravasation and the odds of @entity4 . RESULTS: @entity4 occurred in 14 of the 52 @entity0 (27%) and 20 of the 98 levels (20.4%) remaining after exclusions. Odds of @entity4 were 5.9 times higher (95% CI: 1.6 to 21.2, P = 0.008) with extravasation when compared to no leakage. Odds of @entity4 in a given @entity0 were 22.6 times higher (95% CI: 3.0 to 170.9, P = 0.003) with anterior extravasation when compared to no leakage. Leakage in the middle or posterior thirds and extent of extravasation were not associated with @entity4 . LIMITATIONS: Limitations of the study include the retrospective study design and small sample size as well as the retrospective implementation of follow-up criteria posing risk of selection bias. CONCLUSIONS: Cement endplate extravasation isolated to the anterior third of the vertebral body is associated with is significantly higher odds of @entity4 after VP or KP in @entity0 with @entity3 .

title: Effect of the Location of Endplate Cement Extravasation on Adjacent Level Fracture in Osteoporotic XXXX Undergoing Vertebroplasty and Kyphoplasty.

answer: @entity0


abstract: BACKGROUND: Elderly @entity0 in general exhibit a higher incidence of chronic and @entity1 conditions. This group poses a particular clinical challenge due to age-related pharmacokinetic and pharmacodynamic issues, comorbid conditions, and polypharmacy, as well as frailty and @entity2 . Poor control of @entity4 has consistently been identified as an issue for older @entity0 . The identification of safe and efficacious treatments for @entity5 remains a critical public health concern, especially considering the progressive increase of the world's elderly population. OBJECTIVES: This narrative review deals with the principal alterations of the somatosensory system together with changes in non-neuronal cells in the course of aging. The possibility to control @entity5 based on an innovative strategy which addresses non-neuronal cell dysregulation control will also be discussed. STUDY DESIGN: Narrative review. RESULTS: Peripheral nerves display functional, structural, and biochemical changes with aging that mainly involve A? fibers. Alteration in the responses to @entity4 in the middle insular cortex and primary somatosensory cortex are also observed in the elderly. In general, @entity4 threshold increases with age while the threshold of @entity4 remains unchanged or decreases. Additionally, other important modifications of the @entity4 perception system in this age group consist in a clear reduction in the descending inhibitory capacity with an associated @entity3 . Furthermore, different changes concern immune system cells, such as mast cells and microglia, that with age show an increase in their sensitivity to noxious stimuli and a decreased capability to be regulated by homeostatic endogenous systems. Since these cells are the primary interlocutors for @entity4 neurons, their alterations lead to changes that promote persistent neuroinflammation, thereby impacting @entity4 neuronal cell functionality. LIMITATION: This review is not an exhaustive review for the current evidence supporting the role of immune cells in influencing @entity4 somatosensory neuron functions. It is also important to stress the small number of studies designed to determine the efficacy and safety of anti- @entity4 therapies in elderly @entity0 . CONCLUSION: Non-neuronal cells of immune system origin such as microglia and mast cells, along with astrocytes, are capable of influencing @entity4 somatosensory neuron functions. These nervous system non-neuronal cells may thus be viewed as innovative targets for persistent @entity4 control. Among therapies aiming at preserving the functionality of non-neuronal cells, @entity6 , with its high efficacy/risk ratio, may be an excellent co-treatment for the ever-growing elderly population with @entity5 .

title: XXXX in the Elderly: The Case for New Therapeutic Strategies.

answer: @entity5


abstract: UNASSIGNED: In a proof of concept study, metal-coded affinity tags based on click chemistry (MeCAT-Click) were used to analyze the proteome of @entity1 (E.coli) in response to heat stress. This allows high labeling efficiency, high detection sensitivity, and multiplex capabilities, which are pivotal for its application to protein quantification. Two approaches are presented for relative quantification of differentially @entity4 -labeled proteins. The first approach uses isotope-labeling, where ESI- @entity0 was utilized to quantify the differentially labeled proteins from different states of @entity1 . With this approach, 14 proteins were found with changed abundance, among them five proteins upregulated. In the second approach, differentially labeled samples were separated by two dimensional gel electrophoresis (2-DE) and scanned by @entity3 ( @entity3 ). Comparison of the signal intensities of the different @entity5 was used to quantify different sample states. Based on this information, ESI- @entity0 was used to identify the proteins with different abundance. The sensitivity of @entity3 allowed us to find one upregulated protein that was nearly invisible by @entity2 staining ("Probable replication endonuclease from retron EC67"). The advantage of this approach is to locate low abundant proteins with differential expression using @entity3 , which may be overlooked otherwise. BIOLOGICAL SIGNIFICANCE: This paper demonstrates the successful application of a novel metal labeling strategy to quantify the proteins from complex biological samples. In comparison with former metal labeling strategies, it reduces the steric hindrance and improves the labeling efficiency during the labeling process, which ensure its successful application. This methodology is compatible with both molecular and elemental mass spectrometry. ESI- @entity0 / @entity0 in combination with software-based search allows the identification and relative quantification of labeled proteins. In addition, @entity3 helps to locate the labeled proteins in 2-DE gels with superior detection capability, thus, target proteins with low abundance can be precisely followed. Its excellent sensitivity allows one to track the proteins of interest that are barely visible by @entity2 staining.

title: Application of MeCAT-Click labeling for protein abundance characterization of XXXX after heat shock experiments.

answer: @entity1


abstract: OBJECTIVES: @entity2 are associated with @entity1 and mortality in @entity0 with @entity6 and the general population. METHODS: We assessed the impact of baseline serum @entity7 and @entity5 on longitudinal blood pressure (BP) control and survival in @entity3 adults. We studied 9260 @entity3 adults followed for 40 years (151789 @entity0 -years). Changes in BP over initial 5-year follow-up were analysed using generalized estimating equations. Survival analyses were performed using Cox proportional hazards model. RESULTS: Serum @entity7 levels were higher in @entity3 @entity0 (1.10mmol/l  0.20) than compared to @entity0 (1.02mmol/l  0.21). In treated @entity3 @entity0 , higher baseline serum @entity7 was significantly associated with poor @entity4 (one standard deviation increase in @entity7 was associated with 0.22 and 0.59 mmHg higher SBP at 5 years in @entity0 and @entity0 , respectively). Higher serum @entity7 was significantly associated with all-cause and @entity1 in @entity0 , whereas in @entity0 and women, serum @entity5 significantly predicted all-cause and noncardiovascular mortality. In @entity3 @entity0 with @entity6 , higher @entity7 was significantly associated with poorer survival. CONCLUSION: In @entity3 patients, serum @entity7 and @entity5 are significantly associated with reduced all-cause and cardiovascular survival and this appears not to be related to BP control.

title: Association between serum XXXX and @entity5 , long-term blood pressure, and mortality in treated @entity3 adults.

answer: @entity7


abstract: OBJECTIVES: @entity2 are associated with @entity1 and mortality in @entity0 with @entity6 and the general population. METHODS: We assessed the impact of baseline serum @entity7 and @entity5 on longitudinal blood pressure (BP) control and survival in @entity3 adults. We studied 9260 @entity3 adults followed for 40 years (151789 @entity0 -years). Changes in BP over initial 5-year follow-up were analysed using generalized estimating equations. Survival analyses were performed using Cox proportional hazards model. RESULTS: Serum @entity7 levels were higher in @entity3 @entity0 (1.10mmol/l  0.20) than compared to @entity0 (1.02mmol/l  0.21). In treated @entity3 @entity0 , higher baseline serum @entity7 was significantly associated with poor @entity4 (one standard deviation increase in @entity7 was associated with 0.22 and 0.59 mmHg higher SBP at 5 years in @entity0 and @entity0 , respectively). Higher serum @entity7 was significantly associated with all-cause and @entity1 in @entity0 , whereas in @entity0 and women, serum @entity5 significantly predicted all-cause and noncardiovascular mortality. In @entity3 @entity0 with @entity6 , higher @entity7 was significantly associated with poorer survival. CONCLUSION: In @entity3 patients, serum @entity7 and @entity5 are significantly associated with reduced all-cause and cardiovascular survival and this appears not to be related to BP control.

title: Association between serum @entity7 and @entity5 , long-term blood pressure, and mortality in treated XXXX adults.

answer: @entity3


abstract: OBJECTIVES: @entity2 are associated with @entity1 and mortality in @entity0 with @entity6 and the general population. METHODS: We assessed the impact of baseline serum @entity7 and @entity5 on longitudinal blood pressure (BP) control and survival in @entity3 adults. We studied 9260 @entity3 adults followed for 40 years (151789 @entity0 -years). Changes in BP over initial 5-year follow-up were analysed using generalized estimating equations. Survival analyses were performed using Cox proportional hazards model. RESULTS: Serum @entity7 levels were higher in @entity3 @entity0 (1.10mmol/l  0.20) than compared to @entity0 (1.02mmol/l  0.21). In treated @entity3 @entity0 , higher baseline serum @entity7 was significantly associated with poor @entity4 (one standard deviation increase in @entity7 was associated with 0.22 and 0.59 mmHg higher SBP at 5 years in @entity0 and @entity0 , respectively). Higher serum @entity7 was significantly associated with all-cause and @entity1 in @entity0 , whereas in @entity0 and women, serum @entity5 significantly predicted all-cause and noncardiovascular mortality. In @entity3 @entity0 with @entity6 , higher @entity7 was significantly associated with poorer survival. CONCLUSION: In @entity3 patients, serum @entity7 and @entity5 are significantly associated with reduced all-cause and cardiovascular survival and this appears not to be related to BP control.

title: Association between serum @entity7 and XXXX , long-term blood pressure, and mortality in treated @entity3 adults.

answer: @entity5


abstract: UNASSIGNED: To assess normal and pathological peptidomic changes that may lead to an improved understanding of molecular mechanisms underlying ageing, urinarypeptidomes of 1227 healthy and 10333 diseased individuals between 20 and 86 years of age were investigated. The diseases thereby comprised @entity1 , @entity2 . Using age as a continuous variable, 116 peptides were identified that significantly (p < 0.05;     >= 0.2) correlated with age in the healthy cohort. The same approach was applied to the diseased cohort. Upon comparison of the peptide patterns of the two cohorts 112 common age-correlated peptides were identified. These 112 peptides predominantly originated from collagen, uromodulin and @entity3 . While most fibrillar and basement membrane collagen fragments showed a decreased age-related excretion, uromodulin, @entity4 and @entity3 fragments showed an increase. Peptide-based in silico protease analysis was performed and 32 proteases, including matrix metalloproteinases and cathepsins, were predicted to be involved in ageing. Identified peptides, predicted proteases and @entity0 information were combined in a systems biology pathway analysis to identify molecular pathways associated with normal and/or pathological ageing. While perturbations in collagen homeostasis, trafficking of toll-like receptors and endosomal pathways were commonly identified, degradation of insulin-like growth factor-binding proteins was uniquely identified in pathological ageing.

title: Identification of ageing-associated naturally occurring peptides in XXXX urine.

answer: @entity0


abstract: BACKGROUND: Raised @entity7 ( @entity7 ) is the diagnostic hallmark of @entity4 trait (bTT). @entity3 may arise in @entity1 -positive patients on antiretroviral therapy (ART). We compared the effect of various antiretroviral drugs on @entity7 levels. We attempted to determine which drugs elevate @entity7 levels causing a false-positive diagnosis of bTT and correlate the findings with red cell indices. METHODS: A retrospective analysis of the records of an antenatal @entity2 screening program was carried out for 78 @entity1 -positive adults (70 antenatal @entity0 and 8 husbands) to study the effect of antiretroviral drugs on @entity7 levels. Three had bTT; 20 treatment-na  ve subjects constituted controls. The effects of @entity5 (36 cases), @entity8 (7 cases), and @entity9 (12 cases) were evaluated. High-performance liquid chromatography was done for @entity7 levels. Values of 3.5-3.9% were borderline and   >=    4% with @entity10 microcytosis was considered to be bTT. RESULTS: Twenty individuals not on ART had normal @entity7 %. Three @entity0 had bTT and showed @entity10 microcytosis despite being on @entity5 . Fourteen of 55 @entity0 on treatment (25.5%) had borderline @entity7 values (mean 3.7%): 11 were on a @entity5 -based regimen and 3 on a @entity8 -based regimen. One @entity0 on @entity5 had 4.1% @entity7 with normal Hb and severe @entity6 (MCV 128.5 fl), leading to a false suspicion of bTT. All @entity0 on @entity9 had normal @entity7 . Hematological parameters, including mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and @entity7 levels were increased due to antiretroviral drugs @entity5 and @entity8 . CONCLUSION: Treatment-na  ve subjects and those on @entity9 showed no effect on @entity7 levels compared with @entity5 and @entity8 . A proportion of @entity0 on @entity5 or @entity8 had borderline elevated @entity7 levels, which could lead to a false impression of bTT.

title: Effect of antiretroviral therapy on hemoglobin A2 values can have implications in antenatal XXXX screening programs.

answer: @entity4


abstract: Purpose: Recently, three large genome-wide association studies have identified multiple variants associated with @entity0 ( @entity0 ) near the @entity2 gene. Considering that @entity0 and primary @entity1 (PACG) share many similar clinical manifestations, the present study was conducted to investigate whether these genetic variants were also associated with PACG in a Han Chinese population. Methods: A case-control association study of 1122 cases (PACG/PAC) and 1311 normal, matched controls was undertaken. Seven single-nucleotide polymorphisms (SNPs) near the @entity2 gene, including @entity3 , @entity4 , @entity5 , @entity6 , @entity7 , @entity8 , and @entity9 , were genotyped. Genotype and allele frequencies were assessed using   2 tests. Linkage disequilibrium (LD) structure was analyzed by computer software. Results: Among the SNPs genotyped, no association was observed between these SNPs and PACG. However, we discovered that two haplotypes, CATTTAC (corrected P = 0.048) and CGCCCGC (corrected P = 0.048), remained significantly associated with PACG/PAC after Bonferroni correction. Subjects with the CATTTAC haplotype have a 1.71-fold increased possibility of having PACG/PAC, whereas subjects with the CGCCCGC haplotype have 0.47-fold decreased possibility of developing PACG. Conclusions: Our findings suggest that the genetic backgrounds of PACG and @entity0 might be different. However, whether or not @entity2 plays a role in the development of PACG is still not made certain by this study. Thus, further research is needed to find the role of @entity2 in the progress of PACG.

title: Evaluation of the Association Between Common Genetic Variants Near the XXXX Gene and Primary Angle Closure Glaucoma in a Han Chinese Population.

answer: @entity2


abstract: UNASSIGNED: Although repetitive Transcranial Magnetic Stimulation (rTMS) in treatment of @entity4 in @entity0 has been explored over the past decade the data remain controversial in terms of optimal stimulation parameters and the mechanisms of rTMS long-term effects. This study aimed to explore the potential of different rTMS protocols to induce changes in gene expression in @entity2 cortices after acute @entity3 -reperfusion @entity5 . The @entity4 was induced by @entity6 ( @entity6 ) with subsequent reperfusion. Changes in the expression of 96 genes were examined using low-density expression arrays after @entity6 alone and after @entity6 combined with 1Hz, 5Hz, continuous (cTBS) and intermittent (iTBS) theta-burst rTMS. rTMS over the lesioned hemisphere was given for two weeks (with a 2-day pause) in a single daily session and a total of 2400 pulses. @entity6 alone induced significant upregulation in the expression of 44 genes and downregulation in 10. Two weeks of iTBS induced significant increase in the expression of 52 genes. There were no downregulated genes. 1Hz and 5Hz had no significant effects on gene expression, while cTBS effects were negligible. Upregulated genes included those involved in angiogenesis, @entity1 , injury response and cellular repair, structural remodeling, neuroprotection, neurotransmission and neuronal plasticity. The results show that long-term rTMS in acute @entity3 -reperfusion @entity5 induces complex changes in gene expression that span multiple pathways, which generally promote the recovery. They also demonstrate that induced changes primarily depend on the rTMS frequency (1Hz and 5Hz vs. iTBS) and pattern (cTBS vs. iTBS). The results further underlines the premise that one of the benefits of rTMS application in @entity4 may be to prime the brain, enhancing its potential to cope with the injury and to rewire. This could further augment its potential to favorably respond to rehabilitation, and to restore some of the loss functions.

title: The Effects of Different Repetitive Transcranial Magnetic Stimulation (rTMS) Protocols on Cortical Gene Expression in a XXXX Model of Cerebral Ischemic-Reperfusion Injury.

answer: @entity2


abstract: Several Louisiana parishes (counties) using the Mississippi River for their source of public drinking water have the highest mortality rates (1950-69) in the United States for several @entity1 . Therefore, a case-control mortality study on @entity2 , brain, pancreas, bladder, kidney, prostate, rectum, colon, esophagus, stomach, @entity13 , @entity11 , @entity12 , @entity9 , @entity6 ; breast and malignant @entity5 , from 1960 to 1975 in South Louisiana parishes grouped for similarities in industrial characteristics, having approximately equal exposure of the population to surface and groundwater, was conducted. Noncancer @entity4 were randomly selected as controls and matched to the case @entity4 on age, race, sex, and year and parish group of @entity4 . Water source at @entity4 was assigned based on the residence at @entity4 and described as surface or ground and chlorinated or nonchlorinated. A significantly increased risk for surface, chlorinated water use was noted for @entity1 . No risk could be demonstrated for @entity7 . The risk noted for @entity3 by other investigators is not substantiated. @entity10 risk appears to be associated with chlorinated groundwater, but this may be industrial confounding. @entity0 demonstrated a slight, but significant, risk associated with surface chlorinated water. This risk, however, might be due to confounding of rural life style, early childbearing and large families with nonchlorinated water found in these settings. Chlorination risk for @entity8 was not significant. No risk was observed in association with surface water for other @entity1 of the gastrointestinal or urinary tract. @entity11 was significantly associated with a risk from ground water.

title: Case-control XXXX mortality study and chlorination of drinking water in Louisiana.

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity6 ) has been associated with increased oxidative stress or reduced antioxidant resources. The main goal of this study was to evaluate the levels of serum @entity2 -modified albumin (IMA), oxidized low-density lipoprotein (ox-LDL), @entity3 ( @entity3 ), and total antioxidant status in @entity0 with stable @entity6 , compared with a control group. METHODS: This study was performed on 51 @entity0 with stable @entity6 (42 @entity0 and 9 @entity0 ; mean age 56.92      3.0 years) and 45 healthy control @entity0 (32 @entity0 and 13 @entity0 ; 54.8      3.8 years). The levels of serum lipids, IMA, total antioxidant status, @entity3 , and ox-LDL were measured in all @entity0 . RESULTS: The levels of serum IMA, ox-LDL, and @entity3 were significantly higher in @entity0 with @entity6 than those in control individuals. There was no difference between the levels of serum total antioxidant status, @entity7 , total @entity4 , and low-density lipoprotein @entity4 (LDL-C) of @entity0 with @entity6 and those of control individuals. Serum high-density lipoprotein @entity4 levels were significantly lower in @entity0 with @entity6 than in control individuals. CONCLUSION: Our study indicated that serum IMA, ox-LDL, and @entity3 may be increased as a result of chronic @entity5 , @entity1 , and oxidative stress in @entity0 with severe and very severe stable @entity6 . Our findings also revealed that IMA is higher in @entity0 with Global Initiative for @entity6 Stages II, III, and IV, while @entity3 and ox-LDL are higher in @entity0 with Global Initiative for @entity6 Stage IV. Measurements of serum IMA, @entity3 , and ox-LDL levels may be useful markers in the evaluation of stable @entity6 .

title: Role of oxidative stress and serum lipid levels in stable XXXX .

answer: @entity6


abstract: UNASSIGNED: Congenital portosystemic shunt (CPSS) is persistence of an anomalous embryological connection of the portal vein with a large vein of the vena cava system. Clinical presentations include @entity5 , @entity2 , and @entity1 , but can be variable in timing and symptomatology. We report 2 @entity0 who presented 10 years apart with the same complaint of early pubarche at age 7 years, with inappropriately low @entity8 levels. In addition to @entity10 (elevated @entity3 and @entity7 ) and advanced bone age, both had @entity9 , and hypothyroxinemia. The 2nd case also had symptomatic @entity13 . Presentation of CPSS with this combination of findings in prepubertal @entity0 has not been reported previously. With further investigations, we proposed novel mechanisms explaining these manifestations. @entity10 is caused by decreased hepatic sulfation of @entity6 to less active DHEAS due to shunting of @entity6 to systemic circulation. Elevated @entity6 is then used for synthesis of more potent @entity11 . Shunting of postabsorbtive @entity4 from portal to systemic circulation causes early @entity14 leading to exaggerated insulin secretion. Insulin bypasses the hepatic metabolism directly entering into the systemic circulation, which results in @entity9 , then in turn causes late @entity13 . Finally, hypothyroxinemia was linked to @entity12 deficiency, which has not been reported in CPSS.    2015 S. Karger AG, Basel.

title: Premature Pubarche, XXXX and Hypothyroxinemia: Novel Manifestations of Congenital Portosystemic Shunts (Abernethy Malformation) in @entity0 .

answer: @entity9