abstract: PURPOSE: To describe and analyse relationship between @entity8 and @entity5 . @entity0 AND METHODS: Seven immunocompetent @entity0 examined and treated between November 1992 and March 1996, with @entity6 and @entity5 . RESULTS: Of the 7 @entity0 examined, 5 had active retinochoroiditis and 2 had typical inactive scars. Of the @entity0 with active focus 3 had @entity4 , one had a posterior retinal tear and one had a retinal tear located at the edge of an @entity7 . Of the @entity0 with inactive lesions, one had tractional @entity5 and the other presented with a complete @entity5 , multiples tears and @entity10 . Five @entity0 were treated by @entity3 without antitoxoplasmic drug before they were referred. The seven @entity0 underwent endo-ocular surgery with @entity9 oil or long actic gas tamponade. Three @entity0 developed @entity10 and redetachment of the retina and two @entity0 underwent further surgery. Good anatomical result was obtained in 6 @entity0 . CONCLUSION: @entity5 associated with toxoplasmic retinochoroiditis is rare. However it represents a serious complication. @entity2 administrated to salvage vision may then worsen the clinical course, these may be justified to reduce @entity1 to toxoplasma antigen, but they should be combined with an antimicrobial agent.

title: [Toxoplasmic @entity8 complicated by XXXX ].

answer: @entity5


abstract: PURPOSE: @entity9 and @entity10 encode @entity7 lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by @entity9 and @entity10 can activate the expression of the potent pro-inflammatory cytokine @entity5 , and produce endogenous ligands for @entity8 . In this study, polymorphisms in @entity9 , @entity10 , @entity5 and @entity8 were investigated for association with bone properties in young and elderly Swedish @entity0 . METHODS: Three SNPs in @entity9 , five in @entity10 , one each in @entity5 and @entity8 were genotyped in the cohorts PEAK-25 (n=1061 @entity0 ; all 25y) and OPRA (n=1044 @entity0 ; all 75y). @entity2 ( @entity2 ) and quantitative ultrasound (QUS) were analyzed in both cohorts; @entity2 ( @entity2 ) in PEAK-25; @entity4 , @entity3 incidence and serum @entity6 (CRP) were assessed in OPRA. RESULTS: In the elderly @entity0 @entity10 ( @entity11 ) was associated with CRP levels (p=0.004) and incident @entity3 of any type (p=0.014), although not with @entity2 or ultrasound. In young @entity0 , carrying the common T allele (ALOX 15 @entity12 ) was associated with lower QUS values (p=0.002-0.006). The @entity5 SNP was associated with lower @entity2 in PEAK-25 (femoral neck p=0.034; hip p=0.012). @entity2 was not associated with variation in any gene. Variants in the @entity9 and PPARy were not associated with @entity2 in either cohort. CONCLUSIONS: This study suggests that variation in @entity1 related genes @entity10 and @entity5 was associated with bone microarchitecture and density in young adult @entity0 , but appears to be less important in the elderly, despite an observed association with CRP as a marker of @entity1 and incident @entity3 .

title: Polymorphisms in @entity1 associated genes XXXX and @entity5 are associated with bone properties in young @entity0 and @entity3 in elderly.

answer: @entity10


abstract: PURPOSE: @entity9 and @entity10 encode @entity7 lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by @entity9 and @entity10 can activate the expression of the potent pro-inflammatory cytokine @entity5 , and produce endogenous ligands for @entity8 . In this study, polymorphisms in @entity9 , @entity10 , @entity5 and @entity8 were investigated for association with bone properties in young and elderly Swedish @entity0 . METHODS: Three SNPs in @entity9 , five in @entity10 , one each in @entity5 and @entity8 were genotyped in the cohorts PEAK-25 (n=1061 @entity0 ; all 25y) and OPRA (n=1044 @entity0 ; all 75y). @entity2 ( @entity2 ) and quantitative ultrasound (QUS) were analyzed in both cohorts; @entity2 ( @entity2 ) in PEAK-25; @entity4 , @entity3 incidence and serum @entity6 (CRP) were assessed in OPRA. RESULTS: In the elderly @entity0 @entity10 ( @entity11 ) was associated with CRP levels (p=0.004) and incident @entity3 of any type (p=0.014), although not with @entity2 or ultrasound. In young @entity0 , carrying the common T allele (ALOX 15 @entity12 ) was associated with lower QUS values (p=0.002-0.006). The @entity5 SNP was associated with lower @entity2 in PEAK-25 (femoral neck p=0.034; hip p=0.012). @entity2 was not associated with variation in any gene. Variants in the @entity9 and PPARy were not associated with @entity2 in either cohort. CONCLUSIONS: This study suggests that variation in @entity1 related genes @entity10 and @entity5 was associated with bone microarchitecture and density in young adult @entity0 , but appears to be less important in the elderly, despite an observed association with CRP as a marker of @entity1 and incident @entity3 .

title: Polymorphisms in @entity1 associated genes @entity10 and @entity5 are associated with bone properties in young @entity0 and XXXX in elderly.

answer: @entity3


abstract: PURPOSE: @entity9 and @entity10 encode @entity7 lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by @entity9 and @entity10 can activate the expression of the potent pro-inflammatory cytokine @entity5 , and produce endogenous ligands for @entity8 . In this study, polymorphisms in @entity9 , @entity10 , @entity5 and @entity8 were investigated for association with bone properties in young and elderly Swedish @entity0 . METHODS: Three SNPs in @entity9 , five in @entity10 , one each in @entity5 and @entity8 were genotyped in the cohorts PEAK-25 (n=1061 @entity0 ; all 25y) and OPRA (n=1044 @entity0 ; all 75y). @entity2 ( @entity2 ) and quantitative ultrasound (QUS) were analyzed in both cohorts; @entity2 ( @entity2 ) in PEAK-25; @entity4 , @entity3 incidence and serum @entity6 (CRP) were assessed in OPRA. RESULTS: In the elderly @entity0 @entity10 ( @entity11 ) was associated with CRP levels (p=0.004) and incident @entity3 of any type (p=0.014), although not with @entity2 or ultrasound. In young @entity0 , carrying the common T allele (ALOX 15 @entity12 ) was associated with lower QUS values (p=0.002-0.006). The @entity5 SNP was associated with lower @entity2 in PEAK-25 (femoral neck p=0.034; hip p=0.012). @entity2 was not associated with variation in any gene. Variants in the @entity9 and PPARy were not associated with @entity2 in either cohort. CONCLUSIONS: This study suggests that variation in @entity1 related genes @entity10 and @entity5 was associated with bone microarchitecture and density in young adult @entity0 , but appears to be less important in the elderly, despite an observed association with CRP as a marker of @entity1 and incident @entity3 .

title: Polymorphisms in XXXX associated genes @entity10 and @entity5 are associated with bone properties in young @entity0 and @entity3 in elderly.

answer: @entity1


abstract: PURPOSE: @entity9 and @entity10 encode @entity7 lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by @entity9 and @entity10 can activate the expression of the potent pro-inflammatory cytokine @entity5 , and produce endogenous ligands for @entity8 . In this study, polymorphisms in @entity9 , @entity10 , @entity5 and @entity8 were investigated for association with bone properties in young and elderly Swedish @entity0 . METHODS: Three SNPs in @entity9 , five in @entity10 , one each in @entity5 and @entity8 were genotyped in the cohorts PEAK-25 (n=1061 @entity0 ; all 25y) and OPRA (n=1044 @entity0 ; all 75y). @entity2 ( @entity2 ) and quantitative ultrasound (QUS) were analyzed in both cohorts; @entity2 ( @entity2 ) in PEAK-25; @entity4 , @entity3 incidence and serum @entity6 (CRP) were assessed in OPRA. RESULTS: In the elderly @entity0 @entity10 ( @entity11 ) was associated with CRP levels (p=0.004) and incident @entity3 of any type (p=0.014), although not with @entity2 or ultrasound. In young @entity0 , carrying the common T allele (ALOX 15 @entity12 ) was associated with lower QUS values (p=0.002-0.006). The @entity5 SNP was associated with lower @entity2 in PEAK-25 (femoral neck p=0.034; hip p=0.012). @entity2 was not associated with variation in any gene. Variants in the @entity9 and PPARy were not associated with @entity2 in either cohort. CONCLUSIONS: This study suggests that variation in @entity1 related genes @entity10 and @entity5 was associated with bone microarchitecture and density in young adult @entity0 , but appears to be less important in the elderly, despite an observed association with CRP as a marker of @entity1 and incident @entity3 .

title: Polymorphisms in @entity1 associated genes @entity10 and XXXX are associated with bone properties in young @entity0 and @entity3 in elderly.

answer: @entity5


abstract: PURPOSE: @entity9 and @entity10 encode @entity7 lipoxygenases which produce lipid metabolites involved in inflammatory processes. Metabolites generated by @entity9 and @entity10 can activate the expression of the potent pro-inflammatory cytokine @entity5 , and produce endogenous ligands for @entity8 . In this study, polymorphisms in @entity9 , @entity10 , @entity5 and @entity8 were investigated for association with bone properties in young and elderly Swedish @entity0 . METHODS: Three SNPs in @entity9 , five in @entity10 , one each in @entity5 and @entity8 were genotyped in the cohorts PEAK-25 (n=1061 @entity0 ; all 25y) and OPRA (n=1044 @entity0 ; all 75y). @entity2 ( @entity2 ) and quantitative ultrasound (QUS) were analyzed in both cohorts; @entity2 ( @entity2 ) in PEAK-25; @entity4 , @entity3 incidence and serum @entity6 (CRP) were assessed in OPRA. RESULTS: In the elderly @entity0 @entity10 ( @entity11 ) was associated with CRP levels (p=0.004) and incident @entity3 of any type (p=0.014), although not with @entity2 or ultrasound. In young @entity0 , carrying the common T allele (ALOX 15 @entity12 ) was associated with lower QUS values (p=0.002-0.006). The @entity5 SNP was associated with lower @entity2 in PEAK-25 (femoral neck p=0.034; hip p=0.012). @entity2 was not associated with variation in any gene. Variants in the @entity9 and PPARy were not associated with @entity2 in either cohort. CONCLUSIONS: This study suggests that variation in @entity1 related genes @entity10 and @entity5 was associated with bone microarchitecture and density in young adult @entity0 , but appears to be less important in the elderly, despite an observed association with CRP as a marker of @entity1 and incident @entity3 .

title: Polymorphisms in @entity1 associated genes @entity10 and @entity5 are associated with bone properties in young XXXX and @entity3 in elderly.

answer: @entity0


abstract: BACKGROUND: Over the past decade, the National Action program @entity1 (NAD) was implemented in the Netherlands. Its aim was to introduce the Care Standard (CS) for @entity1 by means of a specific implementation plan and piloting in several regions. This study aimed to provide insight into the implementation of the NAD as, coupled with the introduction of the CS, it may function as an example for similar approaches in other countries. METHODS: A series of quantitative studies ( @entity0 2010: N   =   1726, @entity0 2013: N   =   1370 _ @entity0 pilot regions 2013: N   =   168) and qualitative studies ( @entity0 2010: N   =   18 and @entity0 2013: N   =   4) was conducted among @entity3 ( @entity3 ). In addition, two quantitative studies were conducted among type 1 and 2 @entity0 ( @entity0 2010: N   =   573; @entity0 2013: N   =   5056). RESULTS: Overall, positive changes in @entity1 care were detected in the period 2010 - 2013. In 2013 significantly more @entity3 were familiar with the CS (43.7 versus 37.6  %) and more @entity3 perceived themselves to be working largely or completely in accordance with the CS (89.2 versus 79.0  %) than in 2010. A comparison of the results in specific pilot regions with the rest of the country revealed that @entity3 in these regions scored significantly more positively on implementation and appreciation of the CS. This positive trend was reflected by the high levels of reported @entity0 satisfaction and involvement in treatment. @entity3 who were in possession of the CS had significantly better scores on the implementation of several elements of the CS than @entity3 who were not in possession of the CS. CONCLUSION: The CS has become more prominent and embedded in daily health care practice. In retrospect the CS has provided momentum for the realization of various processes relating to the wider implementation of standards to improve the care for @entity0 with other @entity2 in the Netherlands. Experiences with the NAD and CS underline the need to move towards an integrated multidisciplinary approach of @entity1 care worldwide.

title: The implementation of national action program XXXX in the Netherlands: lessons learned.

answer: @entity1


abstract: UNASSIGNED: Identification of @entity0 with @entity4 -induced @entity3 is encumbered by false positive enzyme-linked immuno assay (ELISA) antibody results, therefore a @entity2 release assay (SRA) is used for confirmation. Recently, several studies have demonstrated that increasing the optical density (OD) threshold (currently at 0.4) of the antibody test enhances the positive predictive value. The purpose of this study was to determine the frequency of @entity0 who were ELISA antibody positive but SRA negative, and the costs and @entity1 events associated with alternative anticoagulant treatment. We hypothesized that treating @entity0 with a positive ELISA antibody OD value of <1.0 would result in increased cost and @entity1 risk. This retrospective chart review was conducted on adult hospitalized @entity0 from 2011 to 2013. @entity0 with positive ELISA antibodies (OD of 0.4-1.0) and an SRA result were included. Eighty-five @entity0 were identified with positive antibodies (average OD of 0.66), 100  % of which were found to be SRA negative. A total of 59 @entity0 (69  %) received alternative anticoagulants. The average duration of treatment was 3.1  days, and 4 @entity0 (4.7  %) experienced a @entity1 event. The cost of testing and laboratory monitoring was  36,346 and the cost of the alternative anticoagulants totaled  47,179. The total cost was  83,525, with an average total cost per @entity0 of  982. This study adds to the body of literature suggesting treatment should only be initiated if the OD is one or greater. The high false positive rate caused increased cost and some @entity1 events.

title: Consequences of treating false positive XXXX -induced @entity3 .

answer: @entity4


abstract: UNASSIGNED: Identification of @entity0 with @entity4 -induced @entity3 is encumbered by false positive enzyme-linked immuno assay (ELISA) antibody results, therefore a @entity2 release assay (SRA) is used for confirmation. Recently, several studies have demonstrated that increasing the optical density (OD) threshold (currently at 0.4) of the antibody test enhances the positive predictive value. The purpose of this study was to determine the frequency of @entity0 who were ELISA antibody positive but SRA negative, and the costs and @entity1 events associated with alternative anticoagulant treatment. We hypothesized that treating @entity0 with a positive ELISA antibody OD value of <1.0 would result in increased cost and @entity1 risk. This retrospective chart review was conducted on adult hospitalized @entity0 from 2011 to 2013. @entity0 with positive ELISA antibodies (OD of 0.4-1.0) and an SRA result were included. Eighty-five @entity0 were identified with positive antibodies (average OD of 0.66), 100  % of which were found to be SRA negative. A total of 59 @entity0 (69  %) received alternative anticoagulants. The average duration of treatment was 3.1  days, and 4 @entity0 (4.7  %) experienced a @entity1 event. The cost of testing and laboratory monitoring was  36,346 and the cost of the alternative anticoagulants totaled  47,179. The total cost was  83,525, with an average total cost per @entity0 of  982. This study adds to the body of literature suggesting treatment should only be initiated if the OD is one or greater. The high false positive rate caused increased cost and some @entity1 events.

title: Consequences of treating false positive @entity4 -induced XXXX .

answer: @entity3


abstract: @entity1 has been reported in association with a variety of antidepressants such as the tricyclic antidepressants (TCAs, e.g. @entity8 , @entity5 , @entity6 , @entity7 , @entity11 ), the selective @entity2 reuptake inhibitors (SSRIs, e.g. @entity3 ), @entity4 and the MAOIs. Apart from lowering the dose and changing the antidepressant, no strategies are available to treat this side effect. In this paper, @entity1 following the administration of @entity10 is described in two @entity0 . Both @entity0 were treated concomitantly with the selective alpha(1A)-adrenoceptor antagonist, @entity9 . A re-challenge was performed in one @entity0 . The Hamilton Depression Rating Scale (HAM-D), the American Urological Association symptom index, a (dis)satisfaction item score and the Udvalg for Kliniske Undersoegelser (UKU-side effect rating scale) were used to assess the treatment. @entity9 rapidly and completely resolved the @entity1 and urinary hesitancy in both @entity0 . A re-challenge in one @entity0 resulted in a prompt reappearance of both side effects. @entity9 resolved the problem of @entity1 in these @entity0 ; however, larger studies are needed to confirm these results.

title: XXXX and urinary hesitancy in association with antidepressant therapy: relief with @entity9 .

answer: @entity1


abstract: @entity1 has been reported in association with a variety of antidepressants such as the tricyclic antidepressants (TCAs, e.g. @entity8 , @entity5 , @entity6 , @entity7 , @entity11 ), the selective @entity2 reuptake inhibitors (SSRIs, e.g. @entity3 ), @entity4 and the MAOIs. Apart from lowering the dose and changing the antidepressant, no strategies are available to treat this side effect. In this paper, @entity1 following the administration of @entity10 is described in two @entity0 . Both @entity0 were treated concomitantly with the selective alpha(1A)-adrenoceptor antagonist, @entity9 . A re-challenge was performed in one @entity0 . The Hamilton Depression Rating Scale (HAM-D), the American Urological Association symptom index, a (dis)satisfaction item score and the Udvalg for Kliniske Undersoegelser (UKU-side effect rating scale) were used to assess the treatment. @entity9 rapidly and completely resolved the @entity1 and urinary hesitancy in both @entity0 . A re-challenge in one @entity0 resulted in a prompt reappearance of both side effects. @entity9 resolved the problem of @entity1 in these @entity0 ; however, larger studies are needed to confirm these results.

title: @entity1 and urinary hesitancy in association with antidepressant therapy: relief with XXXX .

answer: @entity9


abstract: INTRODUCTION: @entity2 is characterized by the retention of gastric contents. Removal of gastric contents is an important part of the treatment strategy. The use of a nasogastric tube alone can result in inadequate removal of gastric contents. We treated a @entity0 with advanced @entity1 and @entity2 with pancrelipase to aid in the removal of gastric contents. PRESENTATION OF CASE: The @entity0 is an 81-year-old @entity0 with a Type 3 @entity1 nearly circumferentially involving the antrum, resulting in @entity2 . A nasogastric tube was placed for four days, but drainage of gastric contents was inadequate. Pancrelipase was then given orally for four days, and gastric contents were evacuated. The @entity0 underwent distal gastrectomy with Roux-en-Y reconstruction and was discharged from the hospital on postoperative day 14. DISCUSSION: This report suggests that pancrelipase may be beneficial in the treatment of @entity0 with @entity2 . CONCLUSION: Pancrelipase allowed gastric contents to be evacuated in a short period of time in a @entity0 with @entity2 .

title: Pretreatment of XXXX with pancrelipase: Report of a case.

answer: @entity2


abstract: INTRODUCTION: @entity4 is the most common extracranial solid pediatric malignancy. The most common site is abdomen with predominance of suprarenal medulla. Infiltration of the @entity1 to the liver is rare. No cases were reported in the literature about the misdiagnosis of @entity4 as @entity5 in the liver. PRESENTATION OF CASE: We represent a rare case of @entity4 misdiagnosed as @entity5 in liver in a six-month-old female @entity0 presented with @entity2 and abdominal mass. Abdominal computed tomography (CT) revealed @entity6 occupying most of the right liver enchroaching upon right suprarenal region and displacing the right kidney inferior suggestive for @entity5 . Right adrenalectomy with en-bloc resection of the adjacent liver segments was done. Postoperative pathology revealed @entity4 with positive specific immunohistochemistry (IHC). DISCUSSION: Although @entity4 is the second most common pediatric abdominal malignancy with specific diagnostic modalities, a misdiagnosis of a case with @entity4 as @entity5 is rare. Histopathological diagnosis of @entity4 with positive IHC is essential as shown in our case. CONCLUSION: We represent a rare case of @entity4 which arose from the right adrenal gland and infiltrated the adjacent liver substance mimicking @entity3 . @entity4 is rarely presented with pyrexia of unknown origin. @entity4 should be considered in differential diagnosis of abdominal mass in all @entity0 and @entity0 .

title: Right adrenal gland neuroblastoma infiltrating the liver and mimicking XXXX : A case report.

answer: @entity5


abstract: Expression of @entity4 protein in 50 @entity1 , @entity0 and recurrent @entity1 of @entity2 has been analyzed by immunohistochemistry. Sixty percent of the @entity1 were at least focally positive for the antigen. There was no correlation between @entity4 expression and histologic grade of the lesions. In contrast, @entity4 expression in T4 and T3 @entity1 was significantly higher than in T2 @entity3 . Immunoreactions in @entity3 with distant @entity0 (MI) were stronger than in M0 cases. However, this difference did not reach statistical significance. The presence of lymph node @entity0 did not correlate with @entity4 expression. High expression of @entity4 in T4 and T3 @entity3 together with the finding of pronounced expression of the antigen at invasion fronts in single cases could be interpreted as a function in @entity1 cell invasion and motility. However, in @entity0 and recurrent @entity1 , @entity4 expression did not differ from primary lesions (53% positive lesions). All in all, under consideration of the latter finding in particular and together with the randomly distributed immunopositive @entity1 cells and cell clusters in the majority of cases, it is more likely that the expression pattern of @entity4 in @entity2 is a result of overall @entity1 cell heterogeneity.

title: The @entity4 protein in XXXX and @entity0 .

answer: @entity2


abstract: Expression of @entity4 protein in 50 @entity1 , @entity0 and recurrent @entity1 of @entity2 has been analyzed by immunohistochemistry. Sixty percent of the @entity1 were at least focally positive for the antigen. There was no correlation between @entity4 expression and histologic grade of the lesions. In contrast, @entity4 expression in T4 and T3 @entity1 was significantly higher than in T2 @entity3 . Immunoreactions in @entity3 with distant @entity0 (MI) were stronger than in M0 cases. However, this difference did not reach statistical significance. The presence of lymph node @entity0 did not correlate with @entity4 expression. High expression of @entity4 in T4 and T3 @entity3 together with the finding of pronounced expression of the antigen at invasion fronts in single cases could be interpreted as a function in @entity1 cell invasion and motility. However, in @entity0 and recurrent @entity1 , @entity4 expression did not differ from primary lesions (53% positive lesions). All in all, under consideration of the latter finding in particular and together with the randomly distributed immunopositive @entity1 cells and cell clusters in the majority of cases, it is more likely that the expression pattern of @entity4 in @entity2 is a result of overall @entity1 cell heterogeneity.

title: The @entity4 protein in @entity2 and XXXX .

answer: @entity0


abstract: Expression of @entity4 protein in 50 @entity1 , @entity0 and recurrent @entity1 of @entity2 has been analyzed by immunohistochemistry. Sixty percent of the @entity1 were at least focally positive for the antigen. There was no correlation between @entity4 expression and histologic grade of the lesions. In contrast, @entity4 expression in T4 and T3 @entity1 was significantly higher than in T2 @entity3 . Immunoreactions in @entity3 with distant @entity0 (MI) were stronger than in M0 cases. However, this difference did not reach statistical significance. The presence of lymph node @entity0 did not correlate with @entity4 expression. High expression of @entity4 in T4 and T3 @entity3 together with the finding of pronounced expression of the antigen at invasion fronts in single cases could be interpreted as a function in @entity1 cell invasion and motility. However, in @entity0 and recurrent @entity1 , @entity4 expression did not differ from primary lesions (53% positive lesions). All in all, under consideration of the latter finding in particular and together with the randomly distributed immunopositive @entity1 cells and cell clusters in the majority of cases, it is more likely that the expression pattern of @entity4 in @entity2 is a result of overall @entity1 cell heterogeneity.

title: The XXXX protein in @entity2 and @entity0 .

answer: @entity4


abstract: BACKGROUND: New-onset @entity1 after transplant (NODAT) is associated with serious morbidity and mortality. The incidence of NODAT is higher with @entity7 ( @entity9 ) compared with @entity3 ( @entity10 ); however, the effects of switching from @entity9 to @entity10 in NODAT have not been studied well. MATERIALS AND METHODS: This was a single-center, open-label, prospective, randomized study, including renal transplant recipients who were on @entity9 -based immunosuppression and developed NODAT. Those with pretransplant @entity1 , @entity2 to @entity10 or @entity9 , severe @entity4 , and denying consent were excluded. Subjects were randomized to either switch to @entity10 or to continue on @entity9 . Fasting and postprandial plasma @entity5 , fasting insulin and C-peptide levels, insulin and oral hypoglycaemic agents (OHA) use were monitored monthly for 3 months, whereas glycosylated haemoglobin (HbA1c) was checked at baseline and 3 months. RESULTS: Sixty-seven subjects were randomized to switch to @entity10 (n  = 32) or continuation of @entity9 (n  = 35). Both groups had similar baseline characteristics. After randomization, there was significant improvement in fasting plasma @entity5 , fasting insulin levels, C-peptide levels, and insulin requirement in both groups, whereas @entity8 c improved significantly only in the @entity10 group. The decline in fasting plasma @entity5 and insulin requirement was more significant in subjects on @entity10 . An equal number of subjects in each group (59.4% in @entity10 group and 40% in @entity9 group, P  = ns) had resolution of NODAT. @entity6 was more significant in the @entity10 group; however, there was no difference in other side effects or rejection episodes. CONCLUSIONS: A switch from @entity7 to @entity3 is a safe and effective strategy in @entity0 with NODAT.

title: Conversion from @entity7 to XXXX in @entity0 with new-onset @entity1 after renal transplant: an open-label randomized prospective pilot study.

answer: @entity3


abstract: BACKGROUND: New-onset @entity1 after transplant (NODAT) is associated with serious morbidity and mortality. The incidence of NODAT is higher with @entity7 ( @entity9 ) compared with @entity3 ( @entity10 ); however, the effects of switching from @entity9 to @entity10 in NODAT have not been studied well. MATERIALS AND METHODS: This was a single-center, open-label, prospective, randomized study, including renal transplant recipients who were on @entity9 -based immunosuppression and developed NODAT. Those with pretransplant @entity1 , @entity2 to @entity10 or @entity9 , severe @entity4 , and denying consent were excluded. Subjects were randomized to either switch to @entity10 or to continue on @entity9 . Fasting and postprandial plasma @entity5 , fasting insulin and C-peptide levels, insulin and oral hypoglycaemic agents (OHA) use were monitored monthly for 3 months, whereas glycosylated haemoglobin (HbA1c) was checked at baseline and 3 months. RESULTS: Sixty-seven subjects were randomized to switch to @entity10 (n  = 32) or continuation of @entity9 (n  = 35). Both groups had similar baseline characteristics. After randomization, there was significant improvement in fasting plasma @entity5 , fasting insulin levels, C-peptide levels, and insulin requirement in both groups, whereas @entity8 c improved significantly only in the @entity10 group. The decline in fasting plasma @entity5 and insulin requirement was more significant in subjects on @entity10 . An equal number of subjects in each group (59.4% in @entity10 group and 40% in @entity9 group, P  = ns) had resolution of NODAT. @entity6 was more significant in the @entity10 group; however, there was no difference in other side effects or rejection episodes. CONCLUSIONS: A switch from @entity7 to @entity3 is a safe and effective strategy in @entity0 with NODAT.

title: Conversion from XXXX to @entity3 in @entity0 with new-onset @entity1 after renal transplant: an open-label randomized prospective pilot study.

answer: @entity7


abstract: BACKGROUND: New-onset @entity1 after transplant (NODAT) is associated with serious morbidity and mortality. The incidence of NODAT is higher with @entity7 ( @entity9 ) compared with @entity3 ( @entity10 ); however, the effects of switching from @entity9 to @entity10 in NODAT have not been studied well. MATERIALS AND METHODS: This was a single-center, open-label, prospective, randomized study, including renal transplant recipients who were on @entity9 -based immunosuppression and developed NODAT. Those with pretransplant @entity1 , @entity2 to @entity10 or @entity9 , severe @entity4 , and denying consent were excluded. Subjects were randomized to either switch to @entity10 or to continue on @entity9 . Fasting and postprandial plasma @entity5 , fasting insulin and C-peptide levels, insulin and oral hypoglycaemic agents (OHA) use were monitored monthly for 3 months, whereas glycosylated haemoglobin (HbA1c) was checked at baseline and 3 months. RESULTS: Sixty-seven subjects were randomized to switch to @entity10 (n  = 32) or continuation of @entity9 (n  = 35). Both groups had similar baseline characteristics. After randomization, there was significant improvement in fasting plasma @entity5 , fasting insulin levels, C-peptide levels, and insulin requirement in both groups, whereas @entity8 c improved significantly only in the @entity10 group. The decline in fasting plasma @entity5 and insulin requirement was more significant in subjects on @entity10 . An equal number of subjects in each group (59.4% in @entity10 group and 40% in @entity9 group, P  = ns) had resolution of NODAT. @entity6 was more significant in the @entity10 group; however, there was no difference in other side effects or rejection episodes. CONCLUSIONS: A switch from @entity7 to @entity3 is a safe and effective strategy in @entity0 with NODAT.

title: Conversion from @entity7 to @entity3 in @entity0 with new-onset XXXX after renal transplant: an open-label randomized prospective pilot study.

answer: @entity1


abstract: BACKGROUND: New-onset @entity1 after transplant (NODAT) is associated with serious morbidity and mortality. The incidence of NODAT is higher with @entity7 ( @entity9 ) compared with @entity3 ( @entity10 ); however, the effects of switching from @entity9 to @entity10 in NODAT have not been studied well. MATERIALS AND METHODS: This was a single-center, open-label, prospective, randomized study, including renal transplant recipients who were on @entity9 -based immunosuppression and developed NODAT. Those with pretransplant @entity1 , @entity2 to @entity10 or @entity9 , severe @entity4 , and denying consent were excluded. Subjects were randomized to either switch to @entity10 or to continue on @entity9 . Fasting and postprandial plasma @entity5 , fasting insulin and C-peptide levels, insulin and oral hypoglycaemic agents (OHA) use were monitored monthly for 3 months, whereas glycosylated haemoglobin (HbA1c) was checked at baseline and 3 months. RESULTS: Sixty-seven subjects were randomized to switch to @entity10 (n  = 32) or continuation of @entity9 (n  = 35). Both groups had similar baseline characteristics. After randomization, there was significant improvement in fasting plasma @entity5 , fasting insulin levels, C-peptide levels, and insulin requirement in both groups, whereas @entity8 c improved significantly only in the @entity10 group. The decline in fasting plasma @entity5 and insulin requirement was more significant in subjects on @entity10 . An equal number of subjects in each group (59.4% in @entity10 group and 40% in @entity9 group, P  = ns) had resolution of NODAT. @entity6 was more significant in the @entity10 group; however, there was no difference in other side effects or rejection episodes. CONCLUSIONS: A switch from @entity7 to @entity3 is a safe and effective strategy in @entity0 with NODAT.

title: Conversion from @entity7 to @entity3 in XXXX with new-onset @entity1 after renal transplant: an open-label randomized prospective pilot study.

answer: @entity0


abstract: OBJECTIVE: We aimed to investigate whether low post-transplantation-period hemoglobin levels are predictive of @entity1 in terms of left ventricular (LV) @entity5 and @entity4 and to determine the contributing factors of post-transplantation @entity3 in kidney transplant (KT) recipients. METHODS: One hundred fifty (mean age, 38.9    10.8  y; 113 male) KT recipients with functioning grafts were enrolled in the study. All subjects underwent clinical and laboratory evaluations (24-hour urinary protein loss, complete blood count) and transthoracic echocardiography to assess LV systolic function. Arterial stiffness was measured by means of carotid-femoral pulse-wave velocity ( @entity2 ). Mean hemoglobin levels were analyzed at the 1st, 6th, 12th, and 24th months after transplantation. @entity0 were divided into 2 groups according to presence of @entity3 : @entity0 with @entity3 (group 1; n  = 120) and normal (group 2; n  = 30). RESULTS: @entity2 values (6.8    1.9  m/s vs 6.4    1.1  m/s in groups 1 and 2, respectively; P  = .002) and LV mass index (LVMI; 252.1    93.7  g/m(2) vs 161.2    38.5  g/m(2) groups 1 and 2, respectively; P  = .001) were significantly higher in group 1. Estimated glomerular filtration rate and (64    28.5  m/min vs 77.8    30  m/min in groups 1 and 2, respectively; P  = .001) LV systolic function (57.2    5.8% vs 77.8    30% in groups 1 and 2, respectively; P  < .005) were significantly lower in group 1. In regression analysis, LV systolic function and LVMI were predictors of post-transplantation hemoglobin levels. CONCLUSIONS: Post-transplantation @entity3 contributes to @entity1 by deteriorating LV function and increasing @entity2 and is therefore associated with poor prognosis for graft survival. Early correction of post-transplantation @entity3 , especially with the use of @entity6 , may be beneficial for both graft and recipient survivals.

title: Post-transplantation Anemia Predicts XXXX and Poor Graft Function in Kidney Transplant Recipients.

answer: @entity1


abstract: Activation of cardiac sympathetic afferents elicits @entity1 and excitatory cardiovascular reflexes including acute @entity0 and @entity3 . Our previous studies have shown that specific regions in the medulla, such as the nucleus of solitary tract and ventrolateral medulla, are involved in central regulation of cardiac sympathoexcitatory reflexes. However, the contributions of supramedullary nuclei to these reflexes have not been characterized. In the present study, we located activated neurons in the pons and midbrain induced by inputs from cardiac sympathetic afferents by detecting their @entity5 immunoreactivity. In anesthetized @entity2 with bilateral carotid denervation and cervical vagotomy, epicardial application of @entity4 (1-10 microg, in 0.1 ml; n=7) was performed on the anterior surface of the left ventricle six times, every 20 min. Repetitive application of @entity4 caused consistent excitatory cardiovascular reflexes characterized by increases in blood pressure and heart rate. No responses were evoked by the vehicle for @entity4 (0.9% saline, n=7). Compared to control @entity2 , @entity5 immunoreactive cells were significantly increased (P<0.05) in the rostral pons, caudal and intermediate midbrain in the @entity4 -treated @entity2 . The specific areas activated include the parabrachial nucleus, K  lliker-Fuse nucleus, locus coeruleus, dorsal nucleus of raphe, and dorsal, lateral and ventrolateral periaqueductal gray. From these results we suggest that cardiovascular-related regions in the pons and midbrain form part of a long loop in central integration of cardiac sympathoexcitatory reflexes.

title: Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in XXXX .

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to determine the types, incidence, and risk factors for early postoperative @entity3 in heart transplant recipients. METHODS: We retrospectively collected data from the records of consecutive heart transplantations from January 2003 to December 2013. A total of 83 @entity0 underwent heart transplantation. The data collected for each case were demographic features, duration of mechanical ventilation, respiratory problems that developed during the intensive care unit (ICU) stay, and early postoperative mortality (<30  d). RESULTS: Of the 72 @entity0 considered, 52 (72.2%) were male. The overall mean age at the time of transplantation was 32.1    16.6 years. Twenty-five @entity0 (34.7%) developed @entity2 . The most frequent problem was @entity6 (n  = 19; 26.4%), followed by @entity5 (n  = 6; 8.3%), acute @entity4 (n  = 5; 6.9%), @entity7 (n  = 4; 5.6%), and @entity1 (n  = 3; 4.2%). Postoperative duration of mechanical ventilation (44.2    59.2  h vs 123.8    190.8 h; P  = .005) and the length of postoperative ICU stay (10.1    5.8  h vs 19.8    28.9 h; P  = .03) were longer among @entity0 who had respiratory problems. Postoperative length of stay in the hospital (22.3    12.5  d vs 30.3    38.3 d; P  = .75) was similar in the 2 groups. The overall mortality rate was 12.5% (n  = 9). The @entity0 who had respiratory problems did not show higher mortality than those who did not have respiratory problems (16.0% vs 10.6%; P  = .71). CONCLUSIONS: Respiratory complications were relatively common in our cohort of heart transplant recipients. However, these complications were mostly self-limiting and did not result in worse mortality.

title: Early postoperative XXXX after heart transplantation.

answer: @entity3


abstract: BACKGROUND: Population-based figures on @entity3 are essential for a realistic assessment of the personal disease burden, prevention modes and the need for caring. The Robert Koch Institute in Germany estimates the incidence of @entity3 as seven cases in 100 000 @entity0 (age-standardized by the European standard rate). Population-based studies presumably show higher incidence rates of 10-16 cases in 100 000 @entity0 . Few data exist for @entity3 ( @entity3 ) as this is not systematically registered in Germany. OBJECTIVES: To present the first population-based results from the Schleswig-Holstein (Germany) Cancer Registry on incidence, stage distribution, clinical types and localization of @entity3 and to compare the results with other studies. METHODS: The Cancer Registry of the Bundesland Schleswig-Holstein with 3500 registering institutions, 100 of which are dermatological institutions, investigates all notifiable incident @entity1 cases according to international standards. From the recorded data all @entity2 and @entity3 cases were identified and evaluated. RESULTS: Between 1998 and 2001, 1784 @entity2 ( @entity2 ) and 12 956 @entity3 cases underwent diagnostic and analytical evaluation. For @entity2 , age-standardized incidence rates were 12.3 and 14.8 in 100 000 @entity0 and @entity0 , respectively, and the mean age of @entity0 was greater than that of @entity0 (56.6 vs. 54.9 years, P < 0.05). @entity2 was the most frequent clinical type (39.1%). The @entity1 were predominantly located on the trunk in @entity0 (46.8%) in contrast to leg and hip in @entity0 (39.5%). For @entity3 , the age-standardized incidence rates were 100.2 and 72.6 in 100 000 @entity0 and @entity0 , respectively. More than 80% of all @entity1 were @entity4 . CONCLUSIONS: The first population-based data from Schleswig-Holstein on the characteristics (age, sex, histological subtypes, localization and stage) of @entity3 agree well with the existing literature and may thus be regarded as representative. However, markedly higher incidences for @entity2 and @entity3 in the north of Germany compared with other parts of the country were observed. As the incidence rates from the north of Germany fit well into the European geographical pattern, we assume no regional increase. Therefore, the official German estimates on cutaneous @entity1 may largely depend on regional factors and may not be regarded as representative for all regions in Germany.

title: Epidemiology of XXXX and @entity3 in Schleswig-Holstein, Germany: incidence, clinical subtypes, @entity1 stages and localization (epidemiology of @entity3 ).

answer: @entity2


abstract: BACKGROUND: Population-based figures on @entity3 are essential for a realistic assessment of the personal disease burden, prevention modes and the need for caring. The Robert Koch Institute in Germany estimates the incidence of @entity3 as seven cases in 100 000 @entity0 (age-standardized by the European standard rate). Population-based studies presumably show higher incidence rates of 10-16 cases in 100 000 @entity0 . Few data exist for @entity3 ( @entity3 ) as this is not systematically registered in Germany. OBJECTIVES: To present the first population-based results from the Schleswig-Holstein (Germany) Cancer Registry on incidence, stage distribution, clinical types and localization of @entity3 and to compare the results with other studies. METHODS: The Cancer Registry of the Bundesland Schleswig-Holstein with 3500 registering institutions, 100 of which are dermatological institutions, investigates all notifiable incident @entity1 cases according to international standards. From the recorded data all @entity2 and @entity3 cases were identified and evaluated. RESULTS: Between 1998 and 2001, 1784 @entity2 ( @entity2 ) and 12 956 @entity3 cases underwent diagnostic and analytical evaluation. For @entity2 , age-standardized incidence rates were 12.3 and 14.8 in 100 000 @entity0 and @entity0 , respectively, and the mean age of @entity0 was greater than that of @entity0 (56.6 vs. 54.9 years, P < 0.05). @entity2 was the most frequent clinical type (39.1%). The @entity1 were predominantly located on the trunk in @entity0 (46.8%) in contrast to leg and hip in @entity0 (39.5%). For @entity3 , the age-standardized incidence rates were 100.2 and 72.6 in 100 000 @entity0 and @entity0 , respectively. More than 80% of all @entity1 were @entity4 . CONCLUSIONS: The first population-based data from Schleswig-Holstein on the characteristics (age, sex, histological subtypes, localization and stage) of @entity3 agree well with the existing literature and may thus be regarded as representative. However, markedly higher incidences for @entity2 and @entity3 in the north of Germany compared with other parts of the country were observed. As the incidence rates from the north of Germany fit well into the European geographical pattern, we assume no regional increase. Therefore, the official German estimates on cutaneous @entity1 may largely depend on regional factors and may not be regarded as representative for all regions in Germany.

title: Epidemiology of @entity2 and @entity3 in Schleswig-Holstein, Germany: incidence, clinical subtypes, XXXX stages and localization (epidemiology of @entity3 ).

answer: @entity1


abstract: BACKGROUND: Population-based figures on @entity3 are essential for a realistic assessment of the personal disease burden, prevention modes and the need for caring. The Robert Koch Institute in Germany estimates the incidence of @entity3 as seven cases in 100 000 @entity0 (age-standardized by the European standard rate). Population-based studies presumably show higher incidence rates of 10-16 cases in 100 000 @entity0 . Few data exist for @entity3 ( @entity3 ) as this is not systematically registered in Germany. OBJECTIVES: To present the first population-based results from the Schleswig-Holstein (Germany) Cancer Registry on incidence, stage distribution, clinical types and localization of @entity3 and to compare the results with other studies. METHODS: The Cancer Registry of the Bundesland Schleswig-Holstein with 3500 registering institutions, 100 of which are dermatological institutions, investigates all notifiable incident @entity1 cases according to international standards. From the recorded data all @entity2 and @entity3 cases were identified and evaluated. RESULTS: Between 1998 and 2001, 1784 @entity2 ( @entity2 ) and 12 956 @entity3 cases underwent diagnostic and analytical evaluation. For @entity2 , age-standardized incidence rates were 12.3 and 14.8 in 100 000 @entity0 and @entity0 , respectively, and the mean age of @entity0 was greater than that of @entity0 (56.6 vs. 54.9 years, P < 0.05). @entity2 was the most frequent clinical type (39.1%). The @entity1 were predominantly located on the trunk in @entity0 (46.8%) in contrast to leg and hip in @entity0 (39.5%). For @entity3 , the age-standardized incidence rates were 100.2 and 72.6 in 100 000 @entity0 and @entity0 , respectively. More than 80% of all @entity1 were @entity4 . CONCLUSIONS: The first population-based data from Schleswig-Holstein on the characteristics (age, sex, histological subtypes, localization and stage) of @entity3 agree well with the existing literature and may thus be regarded as representative. However, markedly higher incidences for @entity2 and @entity3 in the north of Germany compared with other parts of the country were observed. As the incidence rates from the north of Germany fit well into the European geographical pattern, we assume no regional increase. Therefore, the official German estimates on cutaneous @entity1 may largely depend on regional factors and may not be regarded as representative for all regions in Germany.

title: Epidemiology of @entity2 and XXXX in Schleswig-Holstein, Germany: incidence, clinical subtypes, @entity1 stages and localization (epidemiology of @entity3 ).

answer: @entity3


abstract: BACKGROUND: Population-based figures on @entity3 are essential for a realistic assessment of the personal disease burden, prevention modes and the need for caring. The Robert Koch Institute in Germany estimates the incidence of @entity3 as seven cases in 100 000 @entity0 (age-standardized by the European standard rate). Population-based studies presumably show higher incidence rates of 10-16 cases in 100 000 @entity0 . Few data exist for @entity3 ( @entity3 ) as this is not systematically registered in Germany. OBJECTIVES: To present the first population-based results from the Schleswig-Holstein (Germany) Cancer Registry on incidence, stage distribution, clinical types and localization of @entity3 and to compare the results with other studies. METHODS: The Cancer Registry of the Bundesland Schleswig-Holstein with 3500 registering institutions, 100 of which are dermatological institutions, investigates all notifiable incident @entity1 cases according to international standards. From the recorded data all @entity2 and @entity3 cases were identified and evaluated. RESULTS: Between 1998 and 2001, 1784 @entity2 ( @entity2 ) and 12 956 @entity3 cases underwent diagnostic and analytical evaluation. For @entity2 , age-standardized incidence rates were 12.3 and 14.8 in 100 000 @entity0 and @entity0 , respectively, and the mean age of @entity0 was greater than that of @entity0 (56.6 vs. 54.9 years, P < 0.05). @entity2 was the most frequent clinical type (39.1%). The @entity1 were predominantly located on the trunk in @entity0 (46.8%) in contrast to leg and hip in @entity0 (39.5%). For @entity3 , the age-standardized incidence rates were 100.2 and 72.6 in 100 000 @entity0 and @entity0 , respectively. More than 80% of all @entity1 were @entity4 . CONCLUSIONS: The first population-based data from Schleswig-Holstein on the characteristics (age, sex, histological subtypes, localization and stage) of @entity3 agree well with the existing literature and may thus be regarded as representative. However, markedly higher incidences for @entity2 and @entity3 in the north of Germany compared with other parts of the country were observed. As the incidence rates from the north of Germany fit well into the European geographical pattern, we assume no regional increase. Therefore, the official German estimates on cutaneous @entity1 may largely depend on regional factors and may not be regarded as representative for all regions in Germany.

title: Epidemiology of @entity2 and @entity3 in Schleswig-Holstein, Germany: incidence, clinical subtypes, @entity1 stages and localization (epidemiology of XXXX ).

answer: @entity3


abstract: BACKGROUND AND PURPOSE: Surgery is the standard of care in stage I @entity2 ( @entity2 ), but stereotactic ablative radiotherapy (SABR) is increasingly used to treat @entity0 at high-risk for surgical complications. We studied which @entity0 - and clinician-related characteristics influenced treatment recommendations. MATERIAL AND METHODS: A binary choice experiment with hypothetical cases was conducted. Cases varied on five @entity0 -related characteristics: @entity0 age, @entity1 Global Initiative for @entity1 ( @entity1 ) score, Charlson co-morbidity index, World Health Organization performance status (WHO-PS) and @entity0 treatment preference (surgery/SABR). Clinician characteristics were recorded. Responses were analyzed using generalized linear mixed models. RESULTS: 126 clinicians completed the survey. All @entity0 -related characteristics, the clinician speciality, and whether clinicians considered outcomes of surgery comparable to SABR, significantly influenced treatment recommendations. Pulmonologists were most influenced by WHO-PS and comorbidity, whereas comorbidity and age had greatest influence on radiation oncologists and surgeons. Clinicians were less influenced by stated @entity0 preference and @entity1 score. Limited consistency was observed in treatment recommendations. CONCLUSIONS: This study suggests that more efforts are needed to develop uniform approaches for making treatment recommendations, and also to incorporate @entity0 preferences when making treatment decisions for stage I @entity2 .

title: Differences between pulmonologists, thoracic surgeons and radiation oncologists in deciding on the treatment of stage I XXXX : A binary choice experiment.

answer: @entity2


abstract: BACKGROUND: @entity3 is a well-recognized problem after various types of surgery such as amputation, thoracotomy, mastectomy, gallbladder surgery and @entity2 . However, little is known about @entity5 after gynaecologic surgery. Therefore, the aim was to study the incidence of @entity5 after Caesarean section. METHODS: A questionnaire was sent in February/March 2003 to 244 consecutive @entity0 who underwent Caesarean section in a one-year period from 1 October 2001 to 30 September 2002. @entity0 were asked about duration of postoperative @entity4 , and if @entity1 was still present to describe the frequency and intensity of @entity1 and its impact on daily life. The questionnaire also included questions about the Caesarean section and about @entity1 problems elsewhere. RESULTS: A total of 220 @entity0 (90.2%) answered the questionnaire. The mean follow-up time was 10.2 months (range 6-17.6). @entity3 resolved in most @entity0 within 3 months but 27 @entity0 (12.3%) still had @entity1 at the time of the interview. No @entity0 had @entity1 , but in 13 of 27 @entity0 (5.9%) @entity1 was present daily or almost daily. @entity0 with persistent @entity1 (n = 27) had more often undergone general than spinal anaesthesia for the Caesarean section. Frequencies of @entity1 problems elsewhere and recalls of severe @entity3 were also higher among @entity0 with persistent @entity1 . CONCLUSION: @entity5 after Caesarean section seems to be a significant problem in at least 5.9% of @entity0 .

title: XXXX following Caesarean section.

answer: @entity5


abstract: BACKGROUND: Childhood @entity1 (CSA) survivors deal with complex mental, physical and relationship problems in adulthood which negatively affects their well-being and health. The aim of the present paper was to present a description of the Wellness-Program for female CSA survivors, the participating @entity0 's evaluation of the different therapies in the program as well as a qualitative study on their experience of the program's effects on their life, health and well-being. METHOD: The Wellness-Program lasted for 10  weeks with organised schedule 20  hours per week. A team of health professionals used a holistic approach and provided traditional and complementary individual and group therapy focusing on both mind and body. In-depth phenomenological interviews with ten @entity0 , 22-53  years old, were conducted 1  week before and 1  week after the program as well as 15  months later. Data collection and data analysis were guided by the Vancouver School of doing phenomenology. RESULTS: Prior to participating in the program, the @entity0 were unable to work or attend school, were on disability allowance, were socially isolated and had complex health problems. After the Wellness-Program, all the @entity0 , except one, were back to work, school or in further rehabilitation. Furthermore, the in-depth interviews showed that their health and well-being, personal life and relationship with partners, family and friends improved. They felt empowered, more in control and had developed increased trust towards others. Six themes were constructed from the in-depth interviews. They were: feeling totally lost, releasing experiences, developing trusting relationships, gaining control, experiencing positive changes in physical and mental health and, finally, feeling of empowerment. The overriding theme of the study was personal resurrection. CONCLUSIONS: The Wellness-Program contributed considerably to improved health and well-being of the @entity0 . However, further assessment of the program is recommended before making it available within the healthcare system.

title: Personal resurrection: female childhood XXXX ' experience of the Wellness-Program.

answer: @entity1


abstract: @entity7 is a hallmark symptom in @entity0 with unstable @entity8 (UAP). However, little is known regarding the prevalence of an atypical presentation among these @entity0 and its relation to subsequent care. We examined the medical records of 4,167 randomly sampled Medicare @entity0 hospitalized with unstable @entity8 at 22 Alabama hospitals between 1993 and 1999. We defined typical presentation as (1) @entity7 located substernally in the left or right chest, or (2) @entity7 characterized as squeezing, tightness, @entity2 , crushing, arm discomfort, dullness, @entity14 , @entity13 , pressure, or @entity2 aggravated by exercise or relieved with rest or @entity11 . Atypical presentation was defined as confirmed UAP without typical presentation. Among @entity0 with confirmed UAP, 51.7% had atypical presentations. The most frequent symptoms associated with atypical presentation were @entity12 (69.4%), @entity5 (37.7%), diaphoresis (25.2%), @entity10 (10.6%), or @entity2 in the arms (11.5%), epigastrium (8.1%), shoulder (7.4%), or neck (5.9%). Independent predictors of atypical presentation for @entity0 with UAP were older age (odds ratio 1.09, 95% confidence interval 1.01 to 1.17/decade), history of @entity4 (odds ratio 1.49, 95% confidence interval 1.10 to 2.03), and absence of prior @entity6 , @entity9 , or family history of @entity3 . @entity0 with atypical presentation received @entity1 , heparin, and beta-blocker therapy less aggressively, but there was no difference in mortality. Thus, over half of Medicare @entity0 with confirmed UAP had "atypical" presentations. National educational initiatives may need to redefine the classic presentation of UAP to include atypical presentations to ensure appropriate quality of care.

title: Atypical presentations among Medicare beneficiaries with unstable XXXX .

answer: @entity8


abstract: The association between users of combined oral contraceptives and depot- @entity4 ( @entity5 ) for contraception and @entity1 ( @entity1 ) has been controversial because of variations among studies. Like other studies, this cross-sectional study compares @entity1 in users of combined oral contraceptives and @entity5 with that in nonusers. Unlike previous studies, we defined long-term use as >2 years, and we measured more bone sites than previous studies including lumbar spines, femurs, and forearms. The study group consisted of 59 @entity0 aged 30 years to 34 years who had been using combined oral contraceptives for 57.36 +/- 27.02 months with a minimum period of 24 months, 34 @entity0 of the same age who had been using @entity5 as contraceptive for 55.76 +/- 35.31 months, and 62 @entity0 of the same age who had not used any @entity2 hormonal contraceptives for more than 6 months. @entity1 was measured by dual energy photon absorptiometer at lumbar spine 2-4, neck of femur, Ward's triangle of femur, greater trochanter of femur, ultradistal radius, and distal ulnar, respectively. Age, body mass index, and lifestyles of both groups were matched with nonusers. Mean @entity1 at lumbar spine ( @entity3 ) in the @entity5 users was significantly lower than in the controls (1.031 +/- 0.090 vs. 1.096 +/- 0.116, p = 0.007). There were no significant differences in @entity1 values at bone sites other than lumbar spine between @entity5 users and the controls. There were no significant differences in @entity1 values at all bone sites between combined oral contraceptives users and the controls. We conclude that combined oral contraceptives are not associated with changes in values of @entity1 , while @entity5 is associated with decreased @entity1 only at lumbar spine. We comment that @entity2 hormonal contraceptives are safe to use for long-term contraception regarding bone mass effects.

title: Bone mineral density at various anatomic bone sites in @entity0 receiving combined oral contraceptives and depot- XXXX for contraception.

answer: @entity4


abstract: The association between users of combined oral contraceptives and depot- @entity4 ( @entity5 ) for contraception and @entity1 ( @entity1 ) has been controversial because of variations among studies. Like other studies, this cross-sectional study compares @entity1 in users of combined oral contraceptives and @entity5 with that in nonusers. Unlike previous studies, we defined long-term use as >2 years, and we measured more bone sites than previous studies including lumbar spines, femurs, and forearms. The study group consisted of 59 @entity0 aged 30 years to 34 years who had been using combined oral contraceptives for 57.36 +/- 27.02 months with a minimum period of 24 months, 34 @entity0 of the same age who had been using @entity5 as contraceptive for 55.76 +/- 35.31 months, and 62 @entity0 of the same age who had not used any @entity2 hormonal contraceptives for more than 6 months. @entity1 was measured by dual energy photon absorptiometer at lumbar spine 2-4, neck of femur, Ward's triangle of femur, greater trochanter of femur, ultradistal radius, and distal ulnar, respectively. Age, body mass index, and lifestyles of both groups were matched with nonusers. Mean @entity1 at lumbar spine ( @entity3 ) in the @entity5 users was significantly lower than in the controls (1.031 +/- 0.090 vs. 1.096 +/- 0.116, p = 0.007). There were no significant differences in @entity1 values at bone sites other than lumbar spine between @entity5 users and the controls. There were no significant differences in @entity1 values at all bone sites between combined oral contraceptives users and the controls. We conclude that combined oral contraceptives are not associated with changes in values of @entity1 , while @entity5 is associated with decreased @entity1 only at lumbar spine. We comment that @entity2 hormonal contraceptives are safe to use for long-term contraception regarding bone mass effects.

title: Bone mineral density at various anatomic bone sites in XXXX receiving combined oral contraceptives and depot- @entity4 for contraception.

answer: @entity0


abstract: @entity3 ( @entity3 ) are rare and are usually atherosclerotic and/or related to pregnancy. Because pregnancy is the most important predisposing factor, the strong predilection of @entity3 for @entity0 is not surprising. The authors report a case of @entity12 in a @entity0 with chronic @entity6 as the predisposing factor. A 56-year-old @entity0 with @entity4 and @entity13 was resuscitated and underwent endoscopy, but he died 18 hours later of massive @entity13 before definitive surgery could be carried out. At autopsy, there was chronic @entity6 with @entity1 tethering the tail of the pancreas, spleen, and posterior wall of the stomach together. The @entity3 was indented into the posterior wall of the stomach, into which it had ruptured from without. He also had alcoholic @entity1 but no esophageal varices or conventional gastric ulcers. Other important predisposing factors such as @entity10 , @entity7 , @entity15 , and @entity8 were absent. Histologic examination confirmed the @entity2 of the @entity3 . The @entity3 had Monckeberg medial calcinosis but little evidence of @entity5 . The well-documented complications of @entity11 include @entity9 , abscess, @entity14 . This report describes the rare complication of @entity12 , which may be fatal.

title: Fatal splenic arterial aneurysmal @entity2 associated with chronic XXXX .

answer: @entity6


abstract: @entity3 ( @entity3 ) are rare and are usually atherosclerotic and/or related to pregnancy. Because pregnancy is the most important predisposing factor, the strong predilection of @entity3 for @entity0 is not surprising. The authors report a case of @entity12 in a @entity0 with chronic @entity6 as the predisposing factor. A 56-year-old @entity0 with @entity4 and @entity13 was resuscitated and underwent endoscopy, but he died 18 hours later of massive @entity13 before definitive surgery could be carried out. At autopsy, there was chronic @entity6 with @entity1 tethering the tail of the pancreas, spleen, and posterior wall of the stomach together. The @entity3 was indented into the posterior wall of the stomach, into which it had ruptured from without. He also had alcoholic @entity1 but no esophageal varices or conventional gastric ulcers. Other important predisposing factors such as @entity10 , @entity7 , @entity15 , and @entity8 were absent. Histologic examination confirmed the @entity2 of the @entity3 . The @entity3 had Monckeberg medial calcinosis but little evidence of @entity5 . The well-documented complications of @entity11 include @entity9 , abscess, @entity14 . This report describes the rare complication of @entity12 , which may be fatal.

title: Fatal splenic arterial aneurysmal XXXX associated with chronic @entity6 .

answer: @entity2


abstract: BACKGROUND: We examined the influences of a moderate intake level of three types of alcoholic beverages--beer, whisky, and Shochu (Japanese distilled liquor)--on @entity8 and @entity5 metabolism and excretion in healthy male volunteers, concerning (1) the extent of contribution of @entity8 bodies contained in beer to @entity3 metabolism and (2) a comparison between two types of distilled spirits with (whisky) and without (Shochu) aging in oak wood barrel storage. METHODS: Three sets of studies were conducted in which 10 to 13 healthy adult @entity0 were instructed to drink three types of alcoholic beverages at a slightly higher level (0.8 ml of @entity4 equivalent/kg body weight) than moderate drinking (approximately 30.4 ml or less for @entity0 ). A low @entity8 beer was test-manufactured by treating nucleosides that were contained in wort and remained in beer with @entity8 @entity6 phosphorylase derived from Ochrobacterium anthropi, thereby converting them into corresponding @entity8 bases that were easily assimilated by beer @entity1 . RESULTS: Although beer intake enhanced the level of serum @entity3 by 13.6%, blood @entity2 by 26.7%, and insulin level by 5.1-fold, drinking a moderate level of distilled liquor (whisky, Shochu) did not increase the serum @entity3 level or the other two parameters. The serum @entity3 level observed after drinking beer with a @entity8 body concentration reduced by 28% (68% in @entity7 and @entity8 bases) was almost identical to the level observed after drinking regular beer. Whisky has been found to have a property that decreases the serum @entity3 level. Excretion of @entity3 from blood is increased by 27% after drinking whisky. CONCLUSIONS: Moderate drinking of distilled liquors did not enhance serum @entity3 level, blood @entity2 , or insulin level in healthy male subjects. Increased serum @entity3 after beer intake could not be explained mostly with their @entity8 body congeners. Whisky showed the eliminative property in serum @entity3 through excretion of it from blood to urine. At a moderate drinking level, beer and whisky have different effects on @entity8 metabolism or excretion.

title: Influence of moderate drinking on XXXX and @entity5 metabolism.

answer: @entity8


abstract: BACKGROUND: We examined the influences of a moderate intake level of three types of alcoholic beverages--beer, whisky, and Shochu (Japanese distilled liquor)--on @entity8 and @entity5 metabolism and excretion in healthy male volunteers, concerning (1) the extent of contribution of @entity8 bodies contained in beer to @entity3 metabolism and (2) a comparison between two types of distilled spirits with (whisky) and without (Shochu) aging in oak wood barrel storage. METHODS: Three sets of studies were conducted in which 10 to 13 healthy adult @entity0 were instructed to drink three types of alcoholic beverages at a slightly higher level (0.8 ml of @entity4 equivalent/kg body weight) than moderate drinking (approximately 30.4 ml or less for @entity0 ). A low @entity8 beer was test-manufactured by treating nucleosides that were contained in wort and remained in beer with @entity8 @entity6 phosphorylase derived from Ochrobacterium anthropi, thereby converting them into corresponding @entity8 bases that were easily assimilated by beer @entity1 . RESULTS: Although beer intake enhanced the level of serum @entity3 by 13.6%, blood @entity2 by 26.7%, and insulin level by 5.1-fold, drinking a moderate level of distilled liquor (whisky, Shochu) did not increase the serum @entity3 level or the other two parameters. The serum @entity3 level observed after drinking beer with a @entity8 body concentration reduced by 28% (68% in @entity7 and @entity8 bases) was almost identical to the level observed after drinking regular beer. Whisky has been found to have a property that decreases the serum @entity3 level. Excretion of @entity3 from blood is increased by 27% after drinking whisky. CONCLUSIONS: Moderate drinking of distilled liquors did not enhance serum @entity3 level, blood @entity2 , or insulin level in healthy male subjects. Increased serum @entity3 after beer intake could not be explained mostly with their @entity8 body congeners. Whisky showed the eliminative property in serum @entity3 through excretion of it from blood to urine. At a moderate drinking level, beer and whisky have different effects on @entity8 metabolism or excretion.

title: Influence of moderate drinking on @entity8 and XXXX metabolism.

answer: @entity5


abstract: To investigate the contribution of cytokines, proinflammatory @entity2 and inhibitory @entity4 , to @entity3 ( @entity3 ) in a @entity0 model, two studies were performed using adult @entity0 which were injured at T9/T10. In the first study, @entity0 were sacrificed at 1, 6, 24, 96 and 168 h after @entity3 for immunocytochemistry of coronal sections for the presence of mononuclear phagocytes, astrocytes, @entity2 and @entity4 , among other markers. From intervening frozen sections, RNA was extracted for semiquantitative polymerase chain reaction (RT-PCR) analysis of @entity2 and @entity4 . In the second experiment, @entity0 were treated with intravenous @entity4 30 min after injury and sacrificed at 6 and 48 h after injury. Spinal cord sections were immunocytochemically stained and RNA extracted for semiquantitative PCR as mentioned above, as well as quantitation of lesion volume. There were increases in mononuclear phagocytes and astrocytes, as early as 1 h after @entity3 , with steady progression over 168 h after injury. @entity2 and @entity4 was produced locally by mononuclear phagocytes and astrocytes. There was an 18-h delay in peak mRNA production of @entity4 compared to @entity2 . The treatment of @entity3 @entity0 with @entity4 reduced lesion volume by 50% at 48 h and this was associated with decreased accumulation of mononuclear phagocytes in and around the injury site. This reduction of mononuclear phagocyte numbers around the site of @entity1 would reduce their contribution to secondary injury.

title: Treatment of spinal cord impact injury in the XXXX with transforming growth factor-beta.

answer: @entity0


abstract: The aim of the present study was to evaluate both estrogenic effects in directly NP-exposed sexually mature @entity4 and possible transgenerational effects in the offspring of exposed fish. Four months prior to spawning, adult @entity4 of both sexes were exposed intermittently to NP concentrations of 1 and 10 microg/l. At the end of the exposure period, which coincided with the beginning of spawning time, @entity5 levels in the plasma of adult male rainbow showed a significant increase compared to the control group. After exposure to 10 microg NP/l reproduction was impaired as indicated by significantly reduced hatching rates. Histological examination of the testicular tissue of NP-exposed individuals revealed no morphological differences from the controls. In the offspring, @entity5 levels of male individuals were not affected, whereas in females they were significantly higher than in the control progeny. The histological examination revealed no alteration in sex ratios. In single cases, intersex occurred in both male and female offspring of exposed fish. The analysis of sex @entity1 levels revealed a two-fold increase of @entity0 in the plasma of male offspring and a 13-fold elevation of @entity3 in the plasma of female progeny. The present findings indicate that NP, in an environmentally relevant concentration range, acts as a weak @entity2 in directly exposed adult male @entity4 as indicated by elevated plasma @entity5 levels. Reproduction success was reduced as indicated by decreased hatching rates. Hormonal imbalances detected in the offspring of exposed fish indicate a transgenerational effect mediated by the endocrine system.

title: How estrogenic is nonylphenol? A transgenerational study using XXXX ( @entity4 ) as a test organism.

answer: @entity4


abstract: The aim of the present study was to evaluate both estrogenic effects in directly NP-exposed sexually mature @entity4 and possible transgenerational effects in the offspring of exposed fish. Four months prior to spawning, adult @entity4 of both sexes were exposed intermittently to NP concentrations of 1 and 10 microg/l. At the end of the exposure period, which coincided with the beginning of spawning time, @entity5 levels in the plasma of adult male rainbow showed a significant increase compared to the control group. After exposure to 10 microg NP/l reproduction was impaired as indicated by significantly reduced hatching rates. Histological examination of the testicular tissue of NP-exposed individuals revealed no morphological differences from the controls. In the offspring, @entity5 levels of male individuals were not affected, whereas in females they were significantly higher than in the control progeny. The histological examination revealed no alteration in sex ratios. In single cases, intersex occurred in both male and female offspring of exposed fish. The analysis of sex @entity1 levels revealed a two-fold increase of @entity0 in the plasma of male offspring and a 13-fold elevation of @entity3 in the plasma of female progeny. The present findings indicate that NP, in an environmentally relevant concentration range, acts as a weak @entity2 in directly exposed adult male @entity4 as indicated by elevated plasma @entity5 levels. Reproduction success was reduced as indicated by decreased hatching rates. Hormonal imbalances detected in the offspring of exposed fish indicate a transgenerational effect mediated by the endocrine system.

title: How estrogenic is nonylphenol? A transgenerational study using @entity4 ( XXXX ) as a test organism.

answer: @entity4


abstract: PURPOSE: In previous studies in which in vivo confocal microscopy (CM) was used, quantifiable differences were identified in the corneal epithelium and stroma for surfactants producing different degrees of @entity1 . In the present study, in vivo confocal microscopy was used to determine area and depth of the initial corneal changes, and the correlation of the data to cell death was characterized by ex vivo live-dead assay. METHODS: In four groups of @entity0 (12 animals each), 10 microl surfactants known to produce slight, mild, moderate, or severe @entity1 was applied to the central @entity3 ; 4 untreated @entity0 served as controls. Measurements of group total mean epithelial thickness, epithelial cell area, and depth of keratocyte loss in four corneal regions were made by in vivo CM in 6 @entity0 of each group and in 4 control animals at 3 hours and in the remaining @entity0 at 3 hours and 1 day. Corneas were then removed and fixed for conventional histologic examination (two eyes/treatment/group), or regions were excised and placed in culture media containing 2 microM @entity5 ( @entity5 ) and 4 microM @entity4 homodimer. Using laser scanning CM, the number of dead epithelial or stromal cells in a 300 x 300 x 170 microm (in the x, y, and z axes, respectively) volume of the @entity2 was determined. RESULTS: Confocal microscopy showed that application of the slight irritant resulted in decreased epithelial thickness at 3 hours (41.2+/-2.6 microm in treated eyes versus 43.6+/-3 microm in control eyes; n=6 and 4, respectively) and a significant decrease (P < 0.001) in epithelial cell size (630+/-203 microm2 versus 1427.2+/-90.7 microm2). On day 1, mild, moderate, and severe @entity1 caused complete loss of epithelium and disappearance of keratocytes to a depth of 30.8+/-10.7 microm, 47.2+/-10.4 microm, and 764.6+/-159.6 microm (n=6, 5, and 6), respectively. At 3 hours, live-dead assay detected more dead epithelial cells as a percentage of total surface cells (49.2+/-4.5% in slightly @entity1 versus 20.9+/-3.2% in control eyes), significantly correlating with the measurement by in vivo CM of average epithelial cell size in each eye (r=-0.96; P < 0.005). On day 1, mild and moderate @entity1 showed increasing stromal cell death from 9.8+/-16.2 cells to 36.4+/-17.7 cells, which significantly correlated with the depth of stromal injury determined by in vivo CM (r=0.79; P < 0.00001). No surviving keratocytes were detected in severely @entity1 . CONCLUSIONS: The data support the hypothesis that differences in surfactant-induced @entity1 are directly related to area and depth of acute @entity2 .

title: Area and depth of surfactant-induced XXXX correlates with cell death.

answer: @entity2


abstract: OBJECTIVES: @entity0 with solid @entity1 are at greatest risk for dying from their @entity1 in the five years following diagnosis. For most @entity1 , @entity5 from other @entity4 begin to exceed those from @entity1 at some point. As little is known about the causes of @entity5 among long-term survivors of @entity2 , we examined causes of @entity5 by years from diagnosis. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify @entity0 diagnosed with @entity2 between 1988 and 2012. We compared causes of @entity5 by stage, age, and interval time after diagnosis. RESULTS: A total of 67,385 @entity0 were identified. For stage I @entity1 , 13.6% (CI, 13.0-14.2%) died from @entity2 , 4.2% (CI, 3.8-4.5%) from @entity3 , 3.6% (CI, 3.3-3.9%) from other causes and 2.6% (CI, 2.4-2.9%) from other @entity1 ; @entity2 was the leading cause of @entity5 until 7years after diagnosis after which time @entity5 are more frequently due to other causes. For those with @entity1 , 67.8% (CI, 67.3-68.2%) died from @entity2 , 2.8% (CI, 2.6-2.9%) from other causes, 2.3% (CI, 2.2-2.4%) from @entity3 and 1.9% (CI, 1.7-2.0%) from other @entity1 ; @entity2 was the most frequent cause of @entity5 in years 1-15 after which time @entity5 were more commonly due to other causes. CONCLUSIONS: The probability of dying from @entity2 decreases with time. @entity2 remains the most common cause of @entity5 for 15years after diagnosis in @entity0 with @entity1 .

title: Long-term mortality among @entity0 with XXXX .

answer: @entity2


abstract: OBJECTIVES: @entity0 with solid @entity1 are at greatest risk for dying from their @entity1 in the five years following diagnosis. For most @entity1 , @entity5 from other @entity4 begin to exceed those from @entity1 at some point. As little is known about the causes of @entity5 among long-term survivors of @entity2 , we examined causes of @entity5 by years from diagnosis. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify @entity0 diagnosed with @entity2 between 1988 and 2012. We compared causes of @entity5 by stage, age, and interval time after diagnosis. RESULTS: A total of 67,385 @entity0 were identified. For stage I @entity1 , 13.6% (CI, 13.0-14.2%) died from @entity2 , 4.2% (CI, 3.8-4.5%) from @entity3 , 3.6% (CI, 3.3-3.9%) from other causes and 2.6% (CI, 2.4-2.9%) from other @entity1 ; @entity2 was the leading cause of @entity5 until 7years after diagnosis after which time @entity5 are more frequently due to other causes. For those with @entity1 , 67.8% (CI, 67.3-68.2%) died from @entity2 , 2.8% (CI, 2.6-2.9%) from other causes, 2.3% (CI, 2.2-2.4%) from @entity3 and 1.9% (CI, 1.7-2.0%) from other @entity1 ; @entity2 was the most frequent cause of @entity5 in years 1-15 after which time @entity5 were more commonly due to other causes. CONCLUSIONS: The probability of dying from @entity2 decreases with time. @entity2 remains the most common cause of @entity5 for 15years after diagnosis in @entity0 with @entity1 .

title: Long-term mortality among XXXX with @entity2 .

answer: @entity0


abstract: PURPOSE: We describe 2 @entity0 , aged 19 years, who experienced a rolandic @entity5 at ages 4 and 5, respectively, together with the interictal EEG features of @entity7 ( @entity7 ). In adolescence both @entity0 developed photosensitive occipital @entity5 accompanied by spontaneous and photic-induced occipital EEG paroxysms. METHODS: We have been following 33 @entity0 with a history of @entity7 , between ages 12 and 28 years (mean 17 years). Twenty-one of these @entity0 had experienced their last rolandic @entity5 before the age of 10 years and 9 of them had been without treatment since age 11 or earlier. In 2 of these 9 @entity0 , other types of @entity5 recurred after remission of @entity7 . Clinical, EEG, and evoked potential findings on these 2 @entity0 are presented. RESULTS: After having experienced @entity7 , both @entity0 suffered partial @entity5 from age 12, with @entity8 , @entity2 , slow head turning, @entity1 , epigastric discomfort, unresponsiveness, and @entity4 . @entity5 onset was related to watching TV or exposure to bright light. EEG showed interictal occipital spikes, and a photoparoxysmal response limited to the occipital lobes. Visual evoked potentials were greatly increased in amplitude. One @entity0 had two @entity2 and remained @entity5 free after 4 years of follow-up, while the other had @entity5 controlled by an association of @entity6 and @entity9 . CONCLUSIONS: Clinical and neurophysiological characteristics suggest that these two @entity0 may have presented different age-related expressions within the spectrum of a benign @entity5 susceptibility syndrome rather than sharply distinct @entity3 .

title: Adolescent onset of idiopathic photosensitive occipital epilepsy after remission of XXXX .

answer: @entity7


abstract: PURPOSE: The electroencephalographic hallmark of benign childhood @entity1 with centrotemporal spikes (BECTS, or @entity5 ) are characteristically shaped centrotemporal spikes and sharp waves ( @entity4 ). This EEG trait, but not BECTS itself, has been reported to follow an autosomal dominant mode of inheritance with incomplete penetrance and age @entity3 . @entity4 therefore represents a neurobiologic marker for the increased risk of developing BECTS. @entity6 ( @entity6 ) like BECTS is an idiopathic age-dependent @entity1 with a benign course. Observations of @entity2 and BECTS in the same individual are well documented. @entity2 with benign course were found in increased numbers in a series of @entity4 carriers. Two genetic loci, @entity7 and @entity8 , have been mapped in families with @entity6 , making these two loci strong candidates for the @entity4 trait underlying BECTS. The aim of this study was to determine whether these two @entity1 are @entity0 . METHODS: Linkage analysis was performed in 12 families with probands with BECTS and one or more relatives with @entity4 in the EEG with or without BECTS by using polymorphic DNA markers. RESULTS: Assuming an autosomal mode of inheritance with penetrances of 0.9 and 0.45, respectively, both loci were consistently excluded. CONCLUSIONS: The @entity4 trait and @entity7 and @entity8 segregate independently. BECTS and @entity6 therefore appear to be genetically distinct entities. @entity2 may be a underrecognized symptom of the @entity4 trait itself.

title: Benign childhood @entity1 with centrotemporal spikes and electroencephalography trait are not linked to XXXX and @entity8 of @entity6 .

answer: @entity7


abstract: PURPOSE: The electroencephalographic hallmark of benign childhood @entity1 with centrotemporal spikes (BECTS, or @entity5 ) are characteristically shaped centrotemporal spikes and sharp waves ( @entity4 ). This EEG trait, but not BECTS itself, has been reported to follow an autosomal dominant mode of inheritance with incomplete penetrance and age @entity3 . @entity4 therefore represents a neurobiologic marker for the increased risk of developing BECTS. @entity6 ( @entity6 ) like BECTS is an idiopathic age-dependent @entity1 with a benign course. Observations of @entity2 and BECTS in the same individual are well documented. @entity2 with benign course were found in increased numbers in a series of @entity4 carriers. Two genetic loci, @entity7 and @entity8 , have been mapped in families with @entity6 , making these two loci strong candidates for the @entity4 trait underlying BECTS. The aim of this study was to determine whether these two @entity1 are @entity0 . METHODS: Linkage analysis was performed in 12 families with probands with BECTS and one or more relatives with @entity4 in the EEG with or without BECTS by using polymorphic DNA markers. RESULTS: Assuming an autosomal mode of inheritance with penetrances of 0.9 and 0.45, respectively, both loci were consistently excluded. CONCLUSIONS: The @entity4 trait and @entity7 and @entity8 segregate independently. BECTS and @entity6 therefore appear to be genetically distinct entities. @entity2 may be a underrecognized symptom of the @entity4 trait itself.

title: Benign childhood XXXX with centrotemporal spikes and electroencephalography trait are not linked to @entity7 and @entity8 of @entity6 .

answer: @entity1


abstract: PURPOSE: The electroencephalographic hallmark of benign childhood @entity1 with centrotemporal spikes (BECTS, or @entity5 ) are characteristically shaped centrotemporal spikes and sharp waves ( @entity4 ). This EEG trait, but not BECTS itself, has been reported to follow an autosomal dominant mode of inheritance with incomplete penetrance and age @entity3 . @entity4 therefore represents a neurobiologic marker for the increased risk of developing BECTS. @entity6 ( @entity6 ) like BECTS is an idiopathic age-dependent @entity1 with a benign course. Observations of @entity2 and BECTS in the same individual are well documented. @entity2 with benign course were found in increased numbers in a series of @entity4 carriers. Two genetic loci, @entity7 and @entity8 , have been mapped in families with @entity6 , making these two loci strong candidates for the @entity4 trait underlying BECTS. The aim of this study was to determine whether these two @entity1 are @entity0 . METHODS: Linkage analysis was performed in 12 families with probands with BECTS and one or more relatives with @entity4 in the EEG with or without BECTS by using polymorphic DNA markers. RESULTS: Assuming an autosomal mode of inheritance with penetrances of 0.9 and 0.45, respectively, both loci were consistently excluded. CONCLUSIONS: The @entity4 trait and @entity7 and @entity8 segregate independently. BECTS and @entity6 therefore appear to be genetically distinct entities. @entity2 may be a underrecognized symptom of the @entity4 trait itself.

title: Benign childhood @entity1 with centrotemporal spikes and electroencephalography trait are not linked to @entity7 and XXXX of @entity6 .

answer: @entity8


abstract: PURPOSE: The electroencephalographic hallmark of benign childhood @entity1 with centrotemporal spikes (BECTS, or @entity5 ) are characteristically shaped centrotemporal spikes and sharp waves ( @entity4 ). This EEG trait, but not BECTS itself, has been reported to follow an autosomal dominant mode of inheritance with incomplete penetrance and age @entity3 . @entity4 therefore represents a neurobiologic marker for the increased risk of developing BECTS. @entity6 ( @entity6 ) like BECTS is an idiopathic age-dependent @entity1 with a benign course. Observations of @entity2 and BECTS in the same individual are well documented. @entity2 with benign course were found in increased numbers in a series of @entity4 carriers. Two genetic loci, @entity7 and @entity8 , have been mapped in families with @entity6 , making these two loci strong candidates for the @entity4 trait underlying BECTS. The aim of this study was to determine whether these two @entity1 are @entity0 . METHODS: Linkage analysis was performed in 12 families with probands with BECTS and one or more relatives with @entity4 in the EEG with or without BECTS by using polymorphic DNA markers. RESULTS: Assuming an autosomal mode of inheritance with penetrances of 0.9 and 0.45, respectively, both loci were consistently excluded. CONCLUSIONS: The @entity4 trait and @entity7 and @entity8 segregate independently. BECTS and @entity6 therefore appear to be genetically distinct entities. @entity2 may be a underrecognized symptom of the @entity4 trait itself.

title: Benign childhood @entity1 with centrotemporal spikes and electroencephalography trait are not linked to @entity7 and @entity8 of XXXX .

answer: @entity6


abstract: PURPOSE: We wished to determine whether continuous EEG source imaging can predict the location of @entity2 onset with sublobar accuracy in @entity3 ( @entity3 ). METHODS: We retrospectively analyzed the earliest scalp ictal rhythms, recorded with 23- to 27-channel EEG, in 40 @entity0 with intractable @entity3 . A continuous source analysis technique with multiple fixed dipoles (Focus 1.1) decomposed the EEG into source components representing the activity of major cortical sublobar surfaces. For the temporal lobe, these were basal, anterior tip, anterolateral, and posterolateral cortex. Ictal EEG onset was categorized according to its most prominent and leading source component. All @entity0 underwent intracranial EEG studies before @entity1 surgery, and all had a successful surgical outcome (follow-up >1 year). RESULTS: Most @entity0 with ictal rhythms having a predominant basal source component had hippocampal-onset @entity2 , whereas those with @entity2 with prominent lateral source activity had predominantly temporal neocortical @entity2 origins. @entity2 with a prominent anterior temporal tip source component mostly had onset in entorhinal cortex. @entity2 in some @entity0 had several equally large and nearly synchronous source components. These @entity2 , which could be modeled equally well by a single oblique dipole, had onset predominantly in either entorhinal or lateral temporal cortex. CONCLUSIONS: Multiple fixed dipole analysis of scalp EEG can provide information about the origin of temporal lobe @entity2 that is useful in presurgical planning. In particular, it can reliably distinguish @entity2 of mesial temporal origin from those of lateral temporal origin.

title: Continuous source imaging of scalp ictal rhythms in XXXX .

answer: @entity3


abstract: INTRODUCTION: The evidence on the effectiveness of rehabilitation in @entity1 @entity0 is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT). METHODS: We investigated the effect of @entity2 ( @entity2 ) and of two rehabilitation programmes in @entity1 @entity0 . The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. @entity0 were randomised after @entity2 to either CRT, WBVT or standard follow-up (CON). @entity0 were evaluated before, after @entity2 and after 12 weeks of intervention. RESULTS: Of 121 included @entity0 , 70 were randomised to either CON (24), CRT (24) or WBVT (22). After @entity2 , 6MWD decreased with a mean of 38m (95% CI 22-54) and increased with a mean of 95m (95% CI 58-132) in CRT (p<0.0001), 37m (95% CI -1-76) in WBVT (p=0.06) and 1m (95% CI -34-36) in CON (p=0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by @entity2 and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54m increase in 6MWD after intervention. CONCLUSIONS: @entity2 of @entity1 significantly impairs @entity0 ' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT.

title: Rehabilitation in XXXX with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities.

answer: @entity0


abstract: PURPOSE: To report an unusual case of @entity4 ( @entity4 ) following endovascular repair of a @entity2 ( @entity2 ) that had been treated with a stent-graft 3 years prior. CASE REPORT: A 68-year-old @entity0 with a 3-year-old Vanguard bifurcated aortic stent-graft experienced @entity1 and collapse. @entity3 documented by computed tomography was due to dislocation of the left graft limb. A Talent aortomonoiliac graft was deployed, followed by a femorofemoral bypass. No endoleak was evident. A few hours later, the @entity0 became oliguric and hemodynamically unstable. Increased intra-abdominal pressure (IAP) was recorded. Abdominal decompression was performed, removing 1500 mL of blood from the retroperitoneum through an 18-cm lumbotomy; the peritoneum was opened, and another 500 mL of blood was aspirated. The IAP fell immediately, followed by diuresis a few hours later. The @entity0 recovered and was discharged after 27 days. CONCLUSIONS: Some of the perioperative complications seen after conventional @entity2 repair are also encountered after endovascular treatment. @entity4 requires urgent decompression, and less invasive approaches, such as translumbar extraperitoneal decompression, may be a good alternative to a midline laparotomy.

title: Translumbar extraperitoneal decompression for XXXX after endovascular treatment of a ruptured AAA.

answer: @entity4


abstract: Studies of the mushroom bodies of @entity0 have suggested that their gamma lobes specifically support short-term memory, whereas their vertical lobes are essential for long-term memory. Developmental studies have demonstrated that the @entity0 gamma lobe, like its equivalent in the cockroach @entity1 , is supplied by a special class of intrinsic neuron-the clawed Kenyon cells-that are the first to differentiate during early development. To date, however, no account identifies a corresponding lobe in the @entity2 , another taxon used extensively for learning and memory research. Received opinion is that, in this taxon, each of the mushroom body lobes comprises three parallel divisions representing one of three concentric zones of the calyces, called the lip, collar, and basal ring. The present account shows that, although these zones are represented in the lobes, they occupy only two thirds of the vertical lobe. Its lowermost third receives the axons of the clawed class II Kenyon cells, which are the first to differentiate during early development and which represent the whole calyx. This component of the lobe is anatomically and developmentally equivalent to the gamma lobe of @entity0 and has been here named the gamma lobe of the @entity2 . A new class of intrinsic neurons, originating from perikarya distant from the mushroom body, provides a second system of parallel fibers from the calyx to the gamma lobe. A region immediately beneath the calyces, called the neck, is invaded by these neurons as well as by a third class of intrinsic cell that provides connections within the neck of the pedunculus and the basal ring of the calyces. In the @entity2 , the gamma lobe is extensively supplied by afferents from the protocerebrum and gives rise to a distinctive class of efferent neurons. The terminals of these efferents target protocerebral neuropils that are distinct from those receiving efferents from divisions of the vertical lobe that represent the lip, collar, and basal ring. The identification of a gamma lobe unites the mushroom bodies of evolutionarily divergent taxa. The present findings suggest the need for critical reinterpretation of studies that have been predicated on early descriptions of the mushroom body's lobes.

title: Organization of the XXXX mushroom body: representation of the calyx within the vertical and gamma lobes.

answer: @entity2


abstract: BACKGROUND: What is known of neonatal outcomes associated with maternal @entity2 is limited. The impact on the preterm neonate, delivery room (DR) course and need for neonatal intensive care unit (NICU) admission has not been well established. METHODS: A review was done of our 17 county perinatal regions from the New York State Perinatal Data System database over the 3-year period of 1 January 2010-31 December 2012 for mother/baby dyad information for all live births 34-36 6/7 weeks' gestation. The National Institutes of Health body mass index (BMI) classification was used for maternal BMI with the category definitions of underweight, normal, overweight, @entity2 Level I, @entity2 Level II, and @entity2 Level III. RESULTS: Information was obtained on 2155 @entity0 . In this group, 29% had @entity2 BMIs. The incidence of @entity1 ( @entity1 ), @entity1 during gestation and cesarean delivery (CD) in @entity2 mothers was significantly different from normal weight mothers, P<0.001. More @entity0 of Level III mothers required DR resuscitation when compared with @entity0 of normal BMI mothers, 36 vs 16%, P <0.001. The need for assisted ventilation beyond 6   h of age and need for NICU admission was more likely in @entity0 of Level III mothers, P<0.001. @entity0 in all of the @entity2 subgroups had preterm @entity0 with increased birth weights (BWs) compared with preterm @entity0 of normal weight mothers, P<0.001. DISCUSSION: Late preterm @entity0 @entity2 mothers are more likely to be delivered by cesarean section and have larger BWs. We found that @entity0 @entity2 Level III mothers are much more likely to require assisted ventilation in the DR and NICU admission.International Journal of Obesity advance online publication, 30 June 2015; doi:10.1038/ijo.2015.107.

title: XXXX : significance on the preterm neonate.

answer: @entity2


abstract: Gram-negative bacteria especially Enterobacteriaceaespecies have become an increasing etiologic agent of @entity0 . The development of resistance to carbapenems have become an increasing problem in the treatment of @entity0 . Especially carbapenamases are common for Enterobacteriaceae strains. This study was performed to detect the types of carbapenemases in Enterobacteriaceaestrains isolated from various clinical samples. Enterobacteriaceae species were isolated from urine, blood, tracheal aspirates, wound, and other respiratory samples. Susceptibility of isolates to @entity3 , @entity2 and @entity5 was tested. Carbapenemase genes were studied using HyplexSuperBug ID kit. @entity1 (1-13), IMP (1-22), NDM-1, @entity6 (1-10) and OXA-48 genes were investigated. Ninety-five isolates of Enterobacteriaceae spp. were included in the study. Sixty isolates were resistant to @entity3 , @entity2 and @entity5 and 20 isolates were found resistant to @entity3 or @entity5 while 15 were susceptible to all carbapenems. Among the isolates with @entity4 resistance, 57 were positive for one carbapenemase gene and susceptible isolates did not have carbapenemase gene. OXA-48 was found in 49 of the isolates (86%), NDM-1 in 6 (10.5%) isolates, @entity1 in 2 isolates. IMP and @entity6 gene loci were not identified. Carbapenemase genes play a crucial rolein the development and spread of resistant strains.

title: Investigation of @entity1 , IMP, NDM-1, XXXX AND OXA-48 enzymes in Enterobacteriaceae strains.

answer: @entity6