abstract: BACKGROUND: @entity2 ( @entity2 ) is mostly considered a bacterial disease, mainly pneumococcal. This study was conducted to document the impact of sequential 7-valent and the 13-valent pneumococcal conjugate vaccines (PCV7; PCV13) on emergency room and hospitalization for @entity2 among @entity0 <5 years of age. METHODS: This is an ongoing prospective population-based study in southern Israel. The current analysis spans over the period July 2002 through June 2013. @entity2 was defined using the World Health Organization (WHO)'s criteria for radiologically-confirmed @entity1 . PCV7 was introduced in Israel in July 2009 and gradually replaced by PCV13 in November 2010. Pneumococcal conjugate vaccine ( @entity3 ) impact was calculated by comparing incidences during 3 pre-defined periods: pre- @entity3 (2002-2008), PCV7 (2010-2011) and PCV13 (2012-2013). RESULTS: Overall, 10,142 @entity2 occurred. The annual incidences (per 1,000 inhabitants) in @entity0 <5 years old declined from a mean (  standard deviation) of 13.8  0.9 in the pre- @entity3 period to 11.2  2.7 in the PCV7 period and 7.4 in the PCV13 period, representing a reduction of 13% and 47%, respectively. The overall decrease was significantly faster among outpatients than among hospitalized @entity0 (42% and -8%, respectively in the PCV7 period; 68% vs. 32% in hospitalized @entity0 in the PCV13 period). While in @entity0 12-23 months a significant decline was observed during the PCV7 and PCV13 periods, significant declines in @entity2 rates were observed only during the PCV13 period in the <12 months and 24-59 months age groups (44% and 46%, respectively). CONCLUSIONS: A moderate decline in @entity2 in @entity0 <5 years old was observed after PCV7 introduction. In contrast, after PCV13 introduction a substantial reduction in all visits was evident.

title: Impact of PCV7/PCV13 introduction on community-acquired XXXX in @entity0 <5 years.

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) is mostly considered a bacterial disease, mainly pneumococcal. This study was conducted to document the impact of sequential 7-valent and the 13-valent pneumococcal conjugate vaccines (PCV7; PCV13) on emergency room and hospitalization for @entity2 among @entity0 <5 years of age. METHODS: This is an ongoing prospective population-based study in southern Israel. The current analysis spans over the period July 2002 through June 2013. @entity2 was defined using the World Health Organization (WHO)'s criteria for radiologically-confirmed @entity1 . PCV7 was introduced in Israel in July 2009 and gradually replaced by PCV13 in November 2010. Pneumococcal conjugate vaccine ( @entity3 ) impact was calculated by comparing incidences during 3 pre-defined periods: pre- @entity3 (2002-2008), PCV7 (2010-2011) and PCV13 (2012-2013). RESULTS: Overall, 10,142 @entity2 occurred. The annual incidences (per 1,000 inhabitants) in @entity0 <5 years old declined from a mean (  standard deviation) of 13.8  0.9 in the pre- @entity3 period to 11.2  2.7 in the PCV7 period and 7.4 in the PCV13 period, representing a reduction of 13% and 47%, respectively. The overall decrease was significantly faster among outpatients than among hospitalized @entity0 (42% and -8%, respectively in the PCV7 period; 68% vs. 32% in hospitalized @entity0 in the PCV13 period). While in @entity0 12-23 months a significant decline was observed during the PCV7 and PCV13 periods, significant declines in @entity2 rates were observed only during the PCV13 period in the <12 months and 24-59 months age groups (44% and 46%, respectively). CONCLUSIONS: A moderate decline in @entity2 in @entity0 <5 years old was observed after PCV7 introduction. In contrast, after PCV13 introduction a substantial reduction in all visits was evident.

title: Impact of PCV7/PCV13 introduction on community-acquired @entity1 in XXXX <5 years.

answer: @entity0


abstract: The development of the efficient screening system of detecting compounds that promote myogenesis and prevent muscle atrophy is important. @entity0 C2C12 cells are widely used to evaluate myogenesis but the procedures of the assay are not simple and the quantification is not easy. We established C2C12 cells expressing the N-terminal green fluorescence protein (GFP) and the C-terminal GFP (GFP1-10 and GFP11 cells). GFP1-10 and GFP11 cells do not exhibit GFP signals until they are fused. The signal intensity correlates with the expression of myogenic markers and myofusion. Myogenesis-promoting reagents, such as @entity1 ( @entity1 ) and b-guanidinopropionic acid (GPA), enhance the signals, whereas the poly-caspase inhibitor, z-VAD-FMK, suppresses it. GFP signals are observed when myotubes formed by GFP1-10 cells are fused with single nuclear GFP11 cells, and enhanced by @entity1 , GPA, and IBS008738, a recently-reported myogenesis-promoting reagent. Fusion between myotubes formed by GFP1-10 and GFP11 cells is associated with the appearance of GFP signals. @entity1 and GPA augment these signals, whereas NSC23766, Rac inhibitor, decreases them. The conditioned medium of cancer cells suppresses GFP signals during myogenesis and reduces the width of GFP-positive myotubes after differentiation. Thus the novel split GFP-based assay will provide the useful method for the study of myogenesis, myofusion, and atrophy.

title: A new cell-based assay to evaluate myogenesis in XXXX myoblast C2C12 cells.

answer: @entity0


abstract: BACKGROUND: Valve operations for @entity0 presenting with @entity6 ( @entity6 ) complicated by @entity1 are thought to carry elevated risk of @entity2 . Our aim was to compare outcomes of @entity6 @entity0 who undergo surgical intervention early after diagnosis of @entity7 with outcomes of @entity0 without preoperative emboli. METHODS: All @entity0 undergoing operations for left-sided @entity6 between 1996 and 2013 at our institution were reviewed. @entity0 undergoing operations more than 14 days after @entity1 diagnosis (n  = 11) and those with  purely @entity4 (n  = 7) were excluded from the analysis. The study included 308 @entity0 who were stratified according to the presence (STR, n  = 54) or absence of a preoperative @entity7 (NoSTR, n  = 254). Primary outcomes of interest were the development of a new @entity1 and 30-day mortality. RESULTS: Mean time to surgical intervention from @entity1 onset was 6.0    4.1 days. @entity5  (39% STR vs 21% NoSTR, p  = 0.004) @entity3 at operation (52% STR vs 27% NoSTR, p  < 0.001) were more prevalent in STR @entity0 . There was  no significant difference in 30-day mortality (9.3% STR vs 7.1% NoSTR, p  = 0.57) or in the rate of new @entity1 (5 [9.4%] STR vs 12 [4.7%] NoSTR, p  = 0.19) between groups. In addition, there was no difference in 10-year survival between groups (log-rank p  = 0.74). CONCLUSIONS: Early surgical intervention in @entity0 with @entity6 complicated by preoperative @entity7 does not lead to significantly worse postoperative outcomes. Early surgical intervention for @entity6 after @entity1 warrants consideration, particularly in @entity0 with high-risk features such as @entity5 or annular abscess, or both.

title: Early Operation for @entity6 Complicated by Preoperative XXXX Is Not Associated With Worsened Outcomes.

answer: @entity7


abstract: BACKGROUND: Valve operations for @entity0 presenting with @entity6 ( @entity6 ) complicated by @entity1 are thought to carry elevated risk of @entity2 . Our aim was to compare outcomes of @entity6 @entity0 who undergo surgical intervention early after diagnosis of @entity7 with outcomes of @entity0 without preoperative emboli. METHODS: All @entity0 undergoing operations for left-sided @entity6 between 1996 and 2013 at our institution were reviewed. @entity0 undergoing operations more than 14 days after @entity1 diagnosis (n  = 11) and those with  purely @entity4 (n  = 7) were excluded from the analysis. The study included 308 @entity0 who were stratified according to the presence (STR, n  = 54) or absence of a preoperative @entity7 (NoSTR, n  = 254). Primary outcomes of interest were the development of a new @entity1 and 30-day mortality. RESULTS: Mean time to surgical intervention from @entity1 onset was 6.0    4.1 days. @entity5  (39% STR vs 21% NoSTR, p  = 0.004) @entity3 at operation (52% STR vs 27% NoSTR, p  < 0.001) were more prevalent in STR @entity0 . There was  no significant difference in 30-day mortality (9.3% STR vs 7.1% NoSTR, p  = 0.57) or in the rate of new @entity1 (5 [9.4%] STR vs 12 [4.7%] NoSTR, p  = 0.19) between groups. In addition, there was no difference in 10-year survival between groups (log-rank p  = 0.74). CONCLUSIONS: Early surgical intervention in @entity0 with @entity6 complicated by preoperative @entity7 does not lead to significantly worse postoperative outcomes. Early surgical intervention for @entity6 after @entity1 warrants consideration, particularly in @entity0 with high-risk features such as @entity5 or annular abscess, or both.

title: Early Operation for XXXX Complicated by Preoperative @entity7 Is Not Associated With Worsened Outcomes.

answer: @entity6


abstract: BACKGROUND: While antipsychotic-induced @entity1 ( @entity1 ) and @entity6 remain important concerns in the treatment of @entity0 with @entity2 , the relationship between @entity3 rating scales and spontaneously reported @entity1 -related adverse events ( @entity1 -AEs) remains unexplored. METHODS: Data from four randomized, placebo- and @entity5 -controlled @entity4 trials were analyzed to examine the relationship between spontaneously reported @entity1 -AEs with the Simpson Angus Scale (SAS) and Barnes Akathisia Rating Scale (BARS). Categorical summaries were created for each treatment group to show the frequencies of subjects with @entity1 -AEs in each of the SAS and BARS categories at weeks 1, 3, and 6, and agreement between ratings was quantified by means of weighted kappa (k). RESULTS: In general, we found greater frequencies of @entity1 -AEs with increasing severity of the SAS and BARS scores. The @entity1 -AEs reported with a "none" SAS score ranged from 0 to 22.2%, with a "mild" SAS score from 3.3 to 29.0%, and with a "moderate" SAS score from 0 to 100%. No subjects in any treatment group reported "severe" SAS scores or corresponding @entity1 -AEs. Agreement between SAS scores and @entity1 -AEs was poor for @entity4 and placebo (k < 0.2) and only slightly better for @entity5 . The @entity1 -AEs reported with "non questionable" BARS scores ranged from 1.9 to 9.8%, with "mild moderate" BARS scores from 12.8 to 54.6%, and with "marked severe" scores from 0 to 100%. Agreement was modest for @entity4 and placebo (k < 0.4) and moderate for @entity5 (k < 0.6). CONCLUSIONS: These findings may reflect either underreporting of AEs by investigators and subjects or erroneous rating scale evaluations.

title: Relating Spontaneously Reported Extrapyramidal Adverse Events to XXXX Rating Scales.

answer: @entity3


abstract: Obstructive sleep @entity1 is associated with symptoms including habitual snoring, witness @entity2 and excessive @entity0 . @entity1 is related to some occupations which are needed attention for work accident. We aimed to determine the prevalence of snoring, witnessed @entity2 and excessive @entity0 in coal workers and healthy adults in Zonguldak city center, and also evaluate the differences between these groups. This study consisted of 423 underground coal workers and 355 individuals living in centre of Zonguldak. Study and comparison group were chosen by nonstratified randomized sampling method. Data were collected by a questionnaire that included information regarding snoring, witnessed @entity2 and excessive @entity0 . Mean age was 43.3    6.05 years in miners and 44.3    11.8 years in comparison group. In miners, snoring frequency was determined as 42.6%, witnessed @entity2 were 4.0%, and @entity0 were 4.7%. In comparison group, these symptoms were 38.6%, 4.8% and 2.8% respectively. There were no statistical differences between coal workers and comparison group in these symptoms. Also snoring prevalence was higher in smoker miners. We found that major symptoms of @entity1 in coal workers are similar to general population in Zonguldak. Further studies that constucted higher populations and with polysomnography are needed to evaluate these findings.

title: Prevalence of XXXX in coal miners and healthy adults.

answer: @entity1


abstract: BACKGROUND: The @entity4 is associated with @entity6 ( @entity6 ) and with @entity11 ( @entity11 ), but the underlying mechanisms explaining these associations have not yet been completely clarified. The aim was to investigate (i) whether @entity5 can explain the association between the @entity4 and @entity6 and/or the severity of @entity11 , as measured by the ankle-arm index (AAIx); and (ii) whether any such mediation is independent of that from low-grade @entity2 . MATERIALS AND METHODS: We studied 539 subjects (232 @entity0 ) aged 59  4    6  9 years, with an increased risk of type 2 @entity1 and @entity3 . @entity5 and @entity2 scores were calculated from three markers of @entity5 (soluble @entity12 , soluble @entity13 ) and six of @entity2 ( @entity8 , @entity7 , soluble @entity9 , serum amyloid A, ceruloplasmin and @entity10 ). The association between the @entity4 and @entity6 and/or @entity11 , and the mediating role of @entity5 herein was examined with logistic and linear regression analyses, all adjusted for age, sex and smoking. RESULTS: Subjects with the @entity4 (n = 289; 54%) had higher prevalence of @entity6 [OR (95%CI) = 1  75 (1  14; 2  69)] and lower AAIx [b (95% CI) = -0  036 (-0  056; -0  016)]. @entity5 explained 6% of the association between the @entity4 and @entity6 , and 19% of the association with AAIx, whereas low-grade @entity2 explained 26% and 28% of these associations, respectively. Together, the two scores explained 24% and 36% of the association between the @entity4 and @entity6 and AAIx, respectively. CONCLUSIONS: @entity5 explains part of the association between the @entity4 and the severity of @entity11 , but is not involved in the association between the @entity4 and @entity6 . This indicates that the pathophysiologies of coronary and @entity11 are essentially distinct.

title: The association between the @entity4 and peripheral, but not coronary, artery disease is partly mediated by XXXX : the CODAM study.

answer: @entity5


abstract: BACKGROUND: The @entity4 is associated with @entity6 ( @entity6 ) and with @entity11 ( @entity11 ), but the underlying mechanisms explaining these associations have not yet been completely clarified. The aim was to investigate (i) whether @entity5 can explain the association between the @entity4 and @entity6 and/or the severity of @entity11 , as measured by the ankle-arm index (AAIx); and (ii) whether any such mediation is independent of that from low-grade @entity2 . MATERIALS AND METHODS: We studied 539 subjects (232 @entity0 ) aged 59  4    6  9 years, with an increased risk of type 2 @entity1 and @entity3 . @entity5 and @entity2 scores were calculated from three markers of @entity5 (soluble @entity12 , soluble @entity13 ) and six of @entity2 ( @entity8 , @entity7 , soluble @entity9 , serum amyloid A, ceruloplasmin and @entity10 ). The association between the @entity4 and @entity6 and/or @entity11 , and the mediating role of @entity5 herein was examined with logistic and linear regression analyses, all adjusted for age, sex and smoking. RESULTS: Subjects with the @entity4 (n = 289; 54%) had higher prevalence of @entity6 [OR (95%CI) = 1  75 (1  14; 2  69)] and lower AAIx [b (95% CI) = -0  036 (-0  056; -0  016)]. @entity5 explained 6% of the association between the @entity4 and @entity6 , and 19% of the association with AAIx, whereas low-grade @entity2 explained 26% and 28% of these associations, respectively. Together, the two scores explained 24% and 36% of the association between the @entity4 and @entity6 and AAIx, respectively. CONCLUSIONS: @entity5 explains part of the association between the @entity4 and the severity of @entity11 , but is not involved in the association between the @entity4 and @entity6 . This indicates that the pathophysiologies of coronary and @entity11 are essentially distinct.

title: The association between the XXXX and peripheral, but not coronary, artery disease is partly mediated by @entity5 : the CODAM study.

answer: @entity4


abstract: BACKGROUND: The prevalence of @entity6 @entity4 is    1.3% in the United States, with shrimp most commonly reported. Shellfish is one of the top causes of food-induced anaphylactic reactions, yet there are no reported rates of pediatric shrimp @entity5 in the literature. In previously reported adults with shrimp @entity4 , the rate of @entity5 to shrimp was 42%. OBJECTIVE: To describe the rate of @entity5 among @entity0 with shrimp @entity4 , demographics, clinical presentation, and cross-reactive sensitization. METHODS: Retrospective chart review of @entity0  <=18 years old who presented with shrimp @entity4 to Texas @entity0 's Hospital Allergy and Immunology Clinic over 11 years. RESULTS: Sixty-eight @entity0 were identified with shrimp @entity4 (61% male, 39% female), with a median age of diagnosis at 5.6 years (range, 0.96-16.6 years). The rate of @entity5 was 12%, and mucocutaneous symptoms were most common (skin symptoms, 70%; @entity1 , 58%; and @entity2 , 58%). No factors were positively associated with @entity5 , whereas @entity0 without @entity5 had a significantly higher rate of @entity3 compared with those with @entity5 (p = 0.02). African Americans and Asian Americans were disproportionately affected (p < 0.001). There were low rates of cross-sensitization for other crustaceans and for mollusks (57% and 26%, respectively). CONCLUSION: The rate of @entity5 to shrimp was significantly lower in @entity0 with shrimp @entity4 than in adults, and anaphylactic reactions were negatively associated with @entity3 . Cross-reactivity to other crustaceans and mollusks does not uniformly occur. Prospective studies with double blinded placebo-controlled food challenges are needed to further characterize @entity0 with shrimp @entity4 .

title: Risk factors in pediatric shrimp XXXX .

answer: @entity4


abstract: PURPOSE: Although long-term @entity2 ( @entity2 ) survivors generally report a good quality of life, fear of @entity1 recurrence (FCR) remains an important issue. This study investigated whether the @entity1 ( @entity1 ) can detect high FCR, the prevalence, and characteristics of FCR in @entity2 survivors. METHODS: Two hundred and eleven @entity0 who had undergone successful @entity2 surgery in the period 2003-2010 in the Radboud University Medical Center in the Netherlands were asked to participate. All @entity0 were sent an information letter plus questionnaires for collecting information on demographic and medical variables, FCR, distress, and quality of life. RESULTS: Seventy-six @entity0 (36  %; median age of 67.7  years range 41-88  years) completed the questionnaires a median of 5.1  years after surgery. A cut-off score of 14 or higher on the @entity1 was optimal to detect high FCR. Twenty-nine @entity0 (38  %) experienced high levels of FCR, characterized by higher levels of distress, post-traumatic stress symptoms, and lower quality of life. These individuals particularly reacted to disease-related triggers, felt helpless, were worried, and experienced limitations in daily functioning. High FCR was not associated with demographic or medical variables. CONCLUSION: Long after successful @entity2 surgery, FCR is a serious problem that impairs the quality of life for a substantial proportion of @entity0 . With the @entity1 , it is possible to detect high FCR and thereby assist survivors in receiving appropriate care.

title: Fear of @entity1 recurrence in XXXX survivors.

answer: @entity2


abstract: PURPOSE: Although long-term @entity2 ( @entity2 ) survivors generally report a good quality of life, fear of @entity1 recurrence (FCR) remains an important issue. This study investigated whether the @entity1 ( @entity1 ) can detect high FCR, the prevalence, and characteristics of FCR in @entity2 survivors. METHODS: Two hundred and eleven @entity0 who had undergone successful @entity2 surgery in the period 2003-2010 in the Radboud University Medical Center in the Netherlands were asked to participate. All @entity0 were sent an information letter plus questionnaires for collecting information on demographic and medical variables, FCR, distress, and quality of life. RESULTS: Seventy-six @entity0 (36  %; median age of 67.7  years range 41-88  years) completed the questionnaires a median of 5.1  years after surgery. A cut-off score of 14 or higher on the @entity1 was optimal to detect high FCR. Twenty-nine @entity0 (38  %) experienced high levels of FCR, characterized by higher levels of distress, post-traumatic stress symptoms, and lower quality of life. These individuals particularly reacted to disease-related triggers, felt helpless, were worried, and experienced limitations in daily functioning. High FCR was not associated with demographic or medical variables. CONCLUSION: Long after successful @entity2 surgery, FCR is a serious problem that impairs the quality of life for a substantial proportion of @entity0 . With the @entity1 , it is possible to detect high FCR and thereby assist survivors in receiving appropriate care.

title: Fear of XXXX recurrence in @entity2 survivors.

answer: @entity1


abstract: PURPOSE: To evaluate the relationship between height ratio of the iliac crest to L4 (HR), width ratio of the iliac crest to L4 (WR) and L5-S1 @entity1 . METHODS: On T2-weighted sagittal images of the 50 randomly selected @entity0 , two observers graded L5-S1 discs and some other parameters were measured. Then, @entity2 ( @entity2 ) of the L5-S1 nucleus pulposus was calculated. On anteroposterior and lateral radiographs of the same 50 @entity0 ' lumbar spine, the parameters such as the height of the iliac crest were measured and then HR and WR were calculated. Finally, HR, WR and the percentage of the sROM of L5-S1 in L1-S1 segments of the other 51 randomly selected @entity0 were calculated. RESULTS: Positive correlations were found between HR, WR and @entity2 of the L5-S1 disc. Negative correlations were found between HR, WR and modified Pfirrmann scores of L5-S1 nucleus pulposus. A statistically significant negative correlation was found between HR and the percentage of sROM of L5-S1 in L1-S1 segments. CONCLUSIONS: Low HR and (or) WR were the risk factors for L5-S1 @entity1 . High HR could reduce the percentage of sROM of L5-S1 in L1-S1 segments and high HR and (or) WR could reduce the incidence of L5-S1 @entity1 .

title: L5-S1 XXXX and the anatomic parameters of the iliac crest: imaging study.

answer: @entity1


abstract: BACKGROUND: Liver metastasis is associated with poor prognosis in @entity2 . Surgical resection and systemic chemotherapy have been reported to be effective in @entity2 with @entity3 (GCLM). However, the best strategy for GCLM has not been established. METHODS: From May 2009 to July 2014, a consecutive series of GCLM @entity0 in Zhongshan Hospital of Fudan University were studied. Treatment strategies were evaluated with regard to different extents of @entity1 . RESULTS: A total of 163 @entity0 were included. The overall survival was 10.1  months. Active treatment significantly prolongs the survival of GCLM @entity0 . The overall survival time for @entity0 with liver-limited @entity1 and extra-hepatic liver @entity1 was 11.6 mo and 8.7 mo, respectively (P  =  0.012). The median survival time for liver-limited disease of H1, H2 and H3 was 14.2, 15.8, and 8.5 months, respectively (H3 vs H2, P  =  0.001; H3 vs H1, P  =  0.000; H1 vs H2, P  =  0.900). Systemic chemotherapy was chosen as the main strategy for the 'extensive' @entity0 with extra-hepatic @entity1 and H3 type liver-limited @entity1 . @entity0 ' survival was benefited by multi-line chemotherapy. No differences were shown between systemic chemotherapy and curative resection or palliative resection in H1 and H2 liver-limited @entity1 (16.0 mo vs 12.0 mo, P  =  0.711; 16.0 vs 18.8 months, P  =  0.654). CONCLUSION: Systemic chemotherapy was the main treatment for @entity2 @entity0 with liver @entity1 . Curative resection could be considered for highly selected @entity0 .

title: Systemic chemotherapy as a main strategy for liver @entity1 from XXXX .

answer: @entity2


abstract: BACKGROUND: Liver metastasis is associated with poor prognosis in @entity2 . Surgical resection and systemic chemotherapy have been reported to be effective in @entity2 with @entity3 (GCLM). However, the best strategy for GCLM has not been established. METHODS: From May 2009 to July 2014, a consecutive series of GCLM @entity0 in Zhongshan Hospital of Fudan University were studied. Treatment strategies were evaluated with regard to different extents of @entity1 . RESULTS: A total of 163 @entity0 were included. The overall survival was 10.1  months. Active treatment significantly prolongs the survival of GCLM @entity0 . The overall survival time for @entity0 with liver-limited @entity1 and extra-hepatic liver @entity1 was 11.6 mo and 8.7 mo, respectively (P  =  0.012). The median survival time for liver-limited disease of H1, H2 and H3 was 14.2, 15.8, and 8.5 months, respectively (H3 vs H2, P  =  0.001; H3 vs H1, P  =  0.000; H1 vs H2, P  =  0.900). Systemic chemotherapy was chosen as the main strategy for the 'extensive' @entity0 with extra-hepatic @entity1 and H3 type liver-limited @entity1 . @entity0 ' survival was benefited by multi-line chemotherapy. No differences were shown between systemic chemotherapy and curative resection or palliative resection in H1 and H2 liver-limited @entity1 (16.0 mo vs 12.0 mo, P  =  0.711; 16.0 vs 18.8 months, P  =  0.654). CONCLUSION: Systemic chemotherapy was the main treatment for @entity2 @entity0 with liver @entity1 . Curative resection could be considered for highly selected @entity0 .

title: Systemic chemotherapy as a main strategy for liver XXXX from @entity2 .

answer: @entity1


abstract: We sought to determine the clinical, electrophysiological, neuroimaging, and pathological features of @entity11 . Five @entity0 were identified. All cases presented with a gradually progressive @entity8 , @entity7 , and prominent @entity2 . The median duration of symptoms was 7 months (range 3-36 months). Electrophysiological results were in keeping with chronic @entity10 with variable findings of active denervation and reinnervation. MRI demonstrated irregular, large masses involving and surrounding nerve with heterogenous signal characteristics on T1- and T2-weighted and post-contrast sequences. Histopathological features of the nerve slightly varied but shared commonalities including chronic inflammatory infiltrates, increased collagen, and increased numbers of microvessels. @entity9 and decreased density of myelinated fibers were also noted. Three @entity0 were treated with weekly courses of intravenous @entity6 for 3 months. All reported improvement in @entity5 and @entity8 . @entity11 is not a @entity1 and has reactive features of @entity3 , increased vascularity, and marked @entity4 . It presents as a progressive @entity10 with @entity8 , @entity7 , and @entity5 that may be episodic. The primary pathophysiology is unknown but the @entity3 and response to treatment suggests that there may be an immune component.

title: XXXX : clinicopathological characteristics and a potential therapy.

answer: @entity11


abstract: INTRODUCTION: In this study, we evaluated the impacts of organ failure and residual dysfunction on 1-year survival and health care resource use using @entity4 ( @entity4 ) discharge as the starting point. METHODS: We conducted a historical cohort study, including all adult @entity0 discharged alive after at least 72 h of @entity4 stay in a tertiary teaching hospital in Brazil. The starting point of follow-up was @entity4 discharge. Organ failure was defined as a value of 3 or 4 in its corresponding component of the Sequential Organ Failure Assessment score, and residual organ dysfunction was defined as a score of 1 or 2. We fit a multivariate flexible Cox model to predict 1-year survival. RESULTS: We analyzed 690 @entity0 . Mortality at 1 year after discharge was 27%. Using multivariate modeling, age, @entity3 , @entity1 and albumin at @entity4 discharge were the main determinants of 1-year survival. Age and organ failure were non-linearly associated with survival, and the impact of organ failure diminished over time. We conducted a subset analysis with 561 @entity0 (81%) discharged without organ failure within the previous 24 h of discharge, and the number of residual organs in dysfunction remained strongly associated with reduced 1-year survival. The use of health care resources among hospital survivors was substantial within 1 year: 40% of the @entity0 were rehospitalized, 52% visited the emergency department, 90% were seen at the outpatient clinic, 14% attended rehabilitation outpatient services, 11% were followed by the psychological or @entity2 service and 7% used the day hospital facility. Use of health care resources up to 30 days after hospital discharge was associated with the number of organs in dysfunction at @entity4 discharge. CONCLUSIONS: Organ failure was an important determinant of 1-year outcome of critically ill survivors. Nevertheless, the impact of organ failure tended to diminish over time. Resource use after @entity5 was elevated among @entity4 survivors, and a targeted action is needed to deliver appropriate care and to reduce the late @entity5 .

title: One-year survival and resource use after XXXX : impact of organ failure and residual organ dysfunction in a cohort study in Brazil.

answer: @entity5


abstract: PURPOSE: To report spectral-domain optical coherence tomography (OCT) and @entity3 (FAF) features observed in a case of typical retinocytoma. METHODS: Case report. RESULTS: A 17-year-old @entity0 on routine ophthalmologic evaluation for @entity1 had an elevated translucent lesion with peripheral pigmentation and adjacent @entity4 close to the disc in the nasal retinal quadrant of the left eye. The lesion was confirmed to be retinocytoma on fluorescein angiography. Optical coherence tomography revealed a hyperreflective layer akin to preserved nerve fiber layer overlying the lesion in most of the scans. Symmetrical hyporeflective spaces in the underlying choroid and at places sudden disruption of choroid was also observed in the area of @entity2 . Fundus autofluorescence revealed areas of hyperfluorescence, isofluorescence, and hypofluorescence in the different regions of the lesion. These features on FAF were consistent with posttreatment regressed retinoblastoma. Scleral hyperreflectivity on OCT as well as unmasked hyperfluorescence on FAF was observed in areas of @entity4 . CONCLUSIONS: We report novel findings of superficial hyperreflective layer presumed to be preserved nerve fiber layer in a case of typical retinocytoma as well as FAF features consistent with regressed retinoblastoma.

title: Spectral-domain optical coherence tomography and XXXX features in a case of typical retinocytoma.

answer: @entity3


abstract: The kinetics of product inhibition of @entity0 milk @entity5 ( @entity5 ) were studied in a system of emulsified @entity4 (TG) at different fixed initial concentrations of @entity3 [( @entity1 ]0) without a @entity2 (FA) acceptor. In the absence of apolipoprotein C-II (C-II), the apparent Vmax and the nH(TG) (the slope of the corresponding Hill plot for TG) of 1.82 decreased by about 52% and [TG]0.5 increased 13-fold by raising the [ @entity1 ]0 to 0.3 mM. At low [ @entity1 ]0, product inhibition was competitive with respect to TG: the nH( @entity1 ) averaged 1.1, and [ @entity1 ]0.5 was increased about 2-fold by TG. At the higher [ @entity1 ]0, nH( @entity1 ) was 3.5, and TG had no effect on [ @entity1 ]0.5. In the presence of 3 micrograms/mL C-II, the apparent Vmax was 4.3-7.1-fold higher than in its absence, and the nH(TG) was 2.45. Both parameters decreased by only 20-25%, and [TG]0.5 increased only 3-fold at an [ @entity1 ]0 of 0.3 mM. Conversely, nH( @entity1 ) decreased by 35% and [ @entity1 ]0.5 increased 6-fold by increasing TG concentrations. Similar kinetics were observed with very low density lipoproteins (VLDL). At saturating TG and varying C-II concentrations, nH(C-II) was 1.78, and product inhibition was found to be competitive with respect to C-II. At the [ @entity1 ]0 employed, the FA had no effect on enzyme binding to TG emulsions, and there was no evidence that @entity5 catalyzes the reverse reaction. It is concluded that (a) the @entity5 kinetics are those of a multisite enzyme that probably has three high-affinity binding sites for TG, two for C-II, and four for @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Kinetics of product inhibition and mechanisms of XXXX activation by apolipoprotein C-II.

answer: @entity5


abstract: BACKGROUND: Ecological momentary assessment (EMA) uses real-time data collection to assess @entity0 ' behaviors and environments. This paper explores the strengths and limitations of using EMA to examine social and environmental exposure to @entity1 in urban India among older adolescents and adults. OBJECTIVE: Objectives of this study were (1) to describe the methods used in an EMA study of @entity1 use in urban India using a mobile phone app for data collection, (2) to determine the feasibility of using EMA in the chosen setting by drawing on @entity0 completion and compliance rates with the study protocol, and (3) to provide recommendations on implementing mobile phone EMA research in India and other low- and middle-income countries. METHODS: Via mobile phones and the Internet, this study used two EMA surveys: (1) a momentary survey, sent multiple times per day at random to @entity0 , which asked about their real-time @entity1 use (smoked and smokeless) and exposure to pro- and antitobacco messaging in their location, and 2) an end-of-day survey sent at the end of each study day. Trained @entity0 , from Hyderabad and Kolkata, India, reported on their social and environmental exposure to @entity1 over 10 consecutive days. This feasibility study examined @entity0 compliance, exploring factors related to the successful completion of surveys and the validity of EMA data. RESULTS: The sample included 205 @entity0 , the majority of whom were male (135/205, 65.9%). Almost half smoked less than daily (56/205, 27.3%) or daily (43/205, 21.0%), and 4.4% (9/205) used smokeless @entity1 products. @entity0 completed and returned 46.87% and 73.02% of momentary and end-of-day surveys, respectively. Significant predictors of momentary survey completion included employment and completion of end-of-day surveys. End-of-day survey completion was only significantly predicted by momentary survey completion. CONCLUSIONS: This first study of EMA in India offers promising results, although more research is needed on how to increase compliance. End-of-day survey completion, which has a lower research burden, may be the more appropriate approach to understanding behaviors such as @entity1 use within vulnerable populations in challenging locations. Compliance may also be improved by increasing the number of study visits, compliance checks, or opportunities for retraining @entity0 before and during data collection.

title: Using Ecological Momentary Assessment to Study XXXX Behavior in Urban India: There's an App for That.

answer: @entity1


abstract: BACKGROUND: The ambiguity of defining hope impacts the level of readiness faced by health care professionals treating @entity0 with @entity2 , a disease with unpredictable outcomes. This study describes the report of hope and the relationship between hope and mood in adult @entity4 @entity0 at various points in the illness trajectory. METHODS: This was a cross-sectional study with data collection including use of the @entity3 ( @entity3 ), the Profile of Mood States-Short Form (POMS-SF), and clinical information. Descriptive statistics were used to report sample characteristics. Spearman's rho and Mann-Whitney tests were used to compare and differentiate scores. RESULTS: Eighty-two @entity0 ranging in age from 22 to 78 years (median, 44.5 y) participated in the study. @entity0 were primarily male (57.3%), married (76.8%), and had a high-grade @entity2 (35.4%). Nearly half had recurrence, and more than 20% were on active treatment. The overall @entity3 total score for the sample was 41.32 (range: 13-48). @entity0 with recurrence had a lower @entity3 interconnectedness (median = 14.00) score and higher total @entity5 (median = 14.00) compared with @entity0 without recurrence (median = 15.00 and median = 0.00, respectively; P < .05). All negative mood states on the POMS-SF were negatively correlated with @entity3 subscales. CONCLUSIONS: Overall, @entity0 reporting more hope also reported less overall @entity5 As expected, @entity0 with @entity1 recurrence reported lower hope and higher @entity5 than those who were newly diagnosed or without recurrence. Targeting interventions specifically tailored to an individual's needs for improvement in quality of life throughout the disease course may include measures to address hope in order to facilitate positive coping strategies.

title: Hope and mood changes throughout the primary XXXX illness trajectory.

answer: @entity4


abstract: BACKGROUND: Paullinia pinnata is a medicinal plant used for the treatment of @entity1 , including @entity2 in @entity3 . AIM: This study was carried out to investigate the effect of increasing doses of the methanolic leaves extract of @entity5 on hematological parameters in @entity0 . MATERIALS AND METHODS: Thirty-six male @entity0 albino @entity0 were grouped into six groups of six animals each. Five doses; 50,100, 200, 400 and 800 mg/kg body weight of the @entity5 extract were administered separately to five groups. The sixth group served as a control and received only the vehicle (70% physiological saline: 30% @entity4 [v/v]). Administration was done orally daily for 28 days at 24 h interval. On day 29, the animals were made inactive, blood was then collected from the heart and various hematological parameters were evaluated. STATISTICAL ANALYSIS: Analysis of variance was employed. RESULTS: The packed cell volume and red blood cell count increased significantly (P < 0.05) in the treatment groups except at 200 mg/kg dose. The hemoglobin concentration increased in all the treatment groups. The values for the neutrophils at 50, 100, 200 and 800 mg/kg doses were higher than that of the control. The white blood cell count increased significantly (P < 0.05) at 50 and 400 mg/kg doses compared to the control and exceeded the normal physiological range. CONCLUSION: The maximum tolerable dose is 200 mg/kg body weight of the methanolic leaves extract of @entity5 and the extract has anti-anemic property with the ability to increase neutrophils count.

title: Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in @entity0 albino XXXX .

answer: @entity0


abstract: BACKGROUND: Paullinia pinnata is a medicinal plant used for the treatment of @entity1 , including @entity2 in @entity3 . AIM: This study was carried out to investigate the effect of increasing doses of the methanolic leaves extract of @entity5 on hematological parameters in @entity0 . MATERIALS AND METHODS: Thirty-six male @entity0 albino @entity0 were grouped into six groups of six animals each. Five doses; 50,100, 200, 400 and 800 mg/kg body weight of the @entity5 extract were administered separately to five groups. The sixth group served as a control and received only the vehicle (70% physiological saline: 30% @entity4 [v/v]). Administration was done orally daily for 28 days at 24 h interval. On day 29, the animals were made inactive, blood was then collected from the heart and various hematological parameters were evaluated. STATISTICAL ANALYSIS: Analysis of variance was employed. RESULTS: The packed cell volume and red blood cell count increased significantly (P < 0.05) in the treatment groups except at 200 mg/kg dose. The hemoglobin concentration increased in all the treatment groups. The values for the neutrophils at 50, 100, 200 and 800 mg/kg doses were higher than that of the control. The white blood cell count increased significantly (P < 0.05) at 50 and 400 mg/kg doses compared to the control and exceeded the normal physiological range. CONCLUSION: The maximum tolerable dose is 200 mg/kg body weight of the methanolic leaves extract of @entity5 and the extract has anti-anemic property with the ability to increase neutrophils count.

title: Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in XXXX albino @entity0 .

answer: @entity0


abstract: AIM: To compare the efficacy and safety of recombinant streptokinase (rSK) vs @entity5 -based suppositories in acute @entity4 . METHODS: A multicenter (11 sites), randomized (1:1:1), open, controlled trial with parallel groups was performed. All participating @entity0 gave their written, informed consent. After inclusion, @entity0 with acute symptoms of @entity4 were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h (first 3 units) and afterwards every 12 h until 8 administrations were completed (schedule A), one unit every 8 h until 6 units were completed (schedule B), or 25 mg @entity5 once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5, and 10 d post-inclusion. The main end-point was the 5(th)-day response (disappearance of @entity1 and @entity2 , and >=  70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated. RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170 (91.8%; 95%CI: 87.3-96.2), 155/170 (91.2%; 95%CI: 86.6%-95.7%), and 46/170 (27.1%; 95%CI: 20.1%-34.0%) with rSK (schedule A and B) and @entity5 suppositories, respectively. These 64.6% and 63.9% differences (95%CI: 56.7%-72.2% and 55.7%-72.0%) were highly significant (P < 0.001). This advantage was detected since the early 3(rd) day evaluation (68.8% and 64.1% vs 7.1% for the rSK and active control groups, respectively; P < 0.001) and was maintained even at the late 10(th) day assessment (97.1% and 93.5% vs 67.1% for rSK and @entity5 , respectively; P < 0.001). Time to response was 3 d (95%CI: 2.9-3.1) for both rSK groups and 10 d (95%CI: 9.3-10.7) in the @entity5 group. This difference was highly significant (P < 0.001). All subgroup stratified analyses (with or without @entity3 and @entity4 ) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in 4/251 and 14/133 @entity0 with baseline @entity3 in the rSK and @entity5 groups, respectively (P < 0.001). There were no adverse events attributable to the experimental treatment. CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter @entity5 preparation for the treatment of acute @entity4 , as well as having an adequate safety profile.

title: Recombinant streptokinase vs hydrocortisone suppositories in acute XXXX : A randomized controlled trial.

answer: @entity4


abstract: This study aimed to formulate an optimized @entity2 ( @entity5 ) nanoemulsion hydrogel in order to provide a solution for the slow, variable, and incomplete oral drug absorption in @entity0 suffering from @entity3 . Solubility of @entity5 in different oils, surfactants, and cosurfactants was explored utilizing a cubic model mixture design to obtain a nanoemulsion with minimum globule size. Preparation of an optimized @entity5 nanoemulsion hydrogel using a three-factor, three-level Box-Behnken statistical design was conducted. The molecular weight of chitosan (X1), percentage of chitosan (X2), and percentage of @entity6 as a skin permeation enhancer (X3) were selected to study their effects on hydrogel spreadability (Y1) and percent @entity5 permeated through @entity1 skin after 2.5 hours (Y2). A pharmacokinetic study of the optimized @entity5 nanoemulsion hydrogel was conducted in @entity1 . Mixtures of clove oil and castor oil (3:1 ratio), @entity7 and @entity8 (3:1 ratio), and @entity4 and Myo-6V (3:1 ratio) were selected as the oil, surfactant, and cosurfactant phases, respectively. Statistical analysis indicated that the molecular weight of chitosan has a significant antagonistic effect on spreadability, but has no significant effect on the percent @entity5 permeated. The percentage of chitosan also has a significant antagonistic effect on the spreadability and percent @entity5 permeated. On the other hand, the percentage of @entity6 has a significant synergistic effect on percent @entity5 permeated, with no effect on spreadability. The ex vivo study demonstrated that the optimized @entity5 nanoemulsion hydrogel showed a twofold and 1.5-fold higher permeation percentage than the control gel and marketed cream, respectively. The relative bioavailability of the optimized @entity5 nanoemulsion hydrogel improved to 535.2% and 244.6% with respect to the raw @entity5 hydrogel and marketed cream, respectively, confirming improvement of the relative bioavailability of @entity5 in the formulated nanoemulsion hydrogel.

title: Utilization of nanotechnology to enhance percutaneous absorption of @entity2 in the treatment of XXXX .

answer: @entity3


abstract: This study aimed to formulate an optimized @entity2 ( @entity5 ) nanoemulsion hydrogel in order to provide a solution for the slow, variable, and incomplete oral drug absorption in @entity0 suffering from @entity3 . Solubility of @entity5 in different oils, surfactants, and cosurfactants was explored utilizing a cubic model mixture design to obtain a nanoemulsion with minimum globule size. Preparation of an optimized @entity5 nanoemulsion hydrogel using a three-factor, three-level Box-Behnken statistical design was conducted. The molecular weight of chitosan (X1), percentage of chitosan (X2), and percentage of @entity6 as a skin permeation enhancer (X3) were selected to study their effects on hydrogel spreadability (Y1) and percent @entity5 permeated through @entity1 skin after 2.5 hours (Y2). A pharmacokinetic study of the optimized @entity5 nanoemulsion hydrogel was conducted in @entity1 . Mixtures of clove oil and castor oil (3:1 ratio), @entity7 and @entity8 (3:1 ratio), and @entity4 and Myo-6V (3:1 ratio) were selected as the oil, surfactant, and cosurfactant phases, respectively. Statistical analysis indicated that the molecular weight of chitosan has a significant antagonistic effect on spreadability, but has no significant effect on the percent @entity5 permeated. The percentage of chitosan also has a significant antagonistic effect on the spreadability and percent @entity5 permeated. On the other hand, the percentage of @entity6 has a significant synergistic effect on percent @entity5 permeated, with no effect on spreadability. The ex vivo study demonstrated that the optimized @entity5 nanoemulsion hydrogel showed a twofold and 1.5-fold higher permeation percentage than the control gel and marketed cream, respectively. The relative bioavailability of the optimized @entity5 nanoemulsion hydrogel improved to 535.2% and 244.6% with respect to the raw @entity5 hydrogel and marketed cream, respectively, confirming improvement of the relative bioavailability of @entity5 in the formulated nanoemulsion hydrogel.

title: Utilization of nanotechnology to enhance percutaneous absorption of XXXX in the treatment of @entity3 .

answer: @entity2


abstract: The A/J @entity2 is highly susceptible to @entity0 induction and has been widely used as a screening model in carcinogenicity testing and chemoprevention studies. However, the A/J @entity2 model has several disadvantages. Most notably, it develops @entity0 spontaneously. Moreover, there is a considerable gap in our understanding of the underlying mechanisms of @entity3 in the A/J @entity2 . Therefore, we examined the differences between spontaneous and cigarette smoke-related @entity0 in the A/J @entity2 model using mRNA and microRNA (miRNA) profiling. Male A/J @entity2 were exposed whole-body to @entity4 ( @entity4 ) for 18 months. Gene expression interaction term analysis of @entity0 and surrounding non-tumorous parenchyma samples from animals that were exposed to either 300 mg/m(3) @entity4 or sham-exposed to fresh air indicated significant differential expression of 296 genes. Ingenuity Pathway Analysis(  ) ( @entity6 (  )) indicated an overall suppression of the humoral immune response, which was accompanied by a disruption of @entity5 and glycosaminoglycan metabolism and a deregulation of potentially oncogenic miRNA in @entity1 of @entity4 -exposed A/J @entity2 . Thus, we propose that @entity4 exposure leads to severe perturbations in pathways essential for @entity1 recognition by the immune system, thereby potentiating the ability of @entity1 cells to escape from immune surveillance. Further, exposure to @entity4 appeared to affect expression of miRNA, which have previously been implicated in @entity3 and are thought to contribute to @entity1 progression. Finally, we identified a 50-gene expression signature and show its utility in distinguishing between cigarette smoke-related and spontaneous @entity0 .

title: Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related XXXX development in the A/J @entity2 model.

answer: @entity0


abstract: The A/J @entity2 is highly susceptible to @entity0 induction and has been widely used as a screening model in carcinogenicity testing and chemoprevention studies. However, the A/J @entity2 model has several disadvantages. Most notably, it develops @entity0 spontaneously. Moreover, there is a considerable gap in our understanding of the underlying mechanisms of @entity3 in the A/J @entity2 . Therefore, we examined the differences between spontaneous and cigarette smoke-related @entity0 in the A/J @entity2 model using mRNA and microRNA (miRNA) profiling. Male A/J @entity2 were exposed whole-body to @entity4 ( @entity4 ) for 18 months. Gene expression interaction term analysis of @entity0 and surrounding non-tumorous parenchyma samples from animals that were exposed to either 300 mg/m(3) @entity4 or sham-exposed to fresh air indicated significant differential expression of 296 genes. Ingenuity Pathway Analysis(  ) ( @entity6 (  )) indicated an overall suppression of the humoral immune response, which was accompanied by a disruption of @entity5 and glycosaminoglycan metabolism and a deregulation of potentially oncogenic miRNA in @entity1 of @entity4 -exposed A/J @entity2 . Thus, we propose that @entity4 exposure leads to severe perturbations in pathways essential for @entity1 recognition by the immune system, thereby potentiating the ability of @entity1 cells to escape from immune surveillance. Further, exposure to @entity4 appeared to affect expression of miRNA, which have previously been implicated in @entity3 and are thought to contribute to @entity1 progression. Finally, we identified a 50-gene expression signature and show its utility in distinguishing between cigarette smoke-related and spontaneous @entity0 .

title: Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related @entity0 development in the A/J XXXX model.

answer: @entity2


abstract: A series of 60 @entity0 with "high risk" @entity3 (B symptoms, or large mediastinal mass, or @entity2 ) were staged without laparotomy and treated with combined modality treatment: @entity6 , @entity5 , @entity7 , and @entity1 (6 MOPP) plus radiotherapy. @entity0 were restaged after the first three courses of MOPP and the status of response to therapy at that time was called early response to chemotherapy (ERC). The rate of @entity4 mustard and @entity7 delivery (MRD) during the first three cycles of chemotherapy also was assessed. At the completion of the therapy @entity0 were restaged and the final response was assessed. Fifty-two (86.7%) @entity0 entered complete remission (CR). Forty-eight percent of the complete responders achieved CR in the first three courses of MOPP. Eight-year survival and disease-free survival (DFS) rates of the @entity0 achieving CR were 71% and 73%, respectively. Survival and DFS were significantly better for the @entity0 who achieved CR in the first three cycles of chemotherapy than for @entity0 who entered CR at a later stage of therapy: 8-year survival 90% versus 55% (P = 0.00); 8-year DFS 87% versus 59% (P = 0.01). The attainment of a complete ERC was adversely affected by lymphocyte depletion (LD) histologic type (P = 0.01) and MRD less than 65% (P = 0.04). However, when a multivariate regression analysis was used, ERC was the only significant prognostic variable for survival and DFS and its predictive value was confirmed even after correction by MRD. These data suggest that the rapidity of response to chemotherapy could be an important prognostic factor in high-risk @entity3 .

title: Predictive value of the early response to chemotherapy in high-risk stages II and III XXXX .

answer: @entity3


abstract: 1. Thirty-two @entity0 with hemoglobin SC (Hb SC) disease from Rio de Janeiro, Brazil, are described. Mean @entity0 age at the time of study was 20 years, and average age at onset nine years. 2. The main complaint at presentation was @entity1 . Symptoms involved @entity1 in 72% of the @entity0 , while 59% presented @entity3 and 50% @entity2 . Mean hemoglobin level was 10.6 g/dl, erythrocyte count, 3.9 X 10(6)/mm3, and serum @entity4 , 1.4 g/dl. Reticulocytes and Hb F were 3.0% and 2.2%, respectively. 3. The characteristics of @entity5 observed in the present study did not differ significantly from those of other series studied elsewhere. This relative homogeneity of data is probably related to the physiopathological mechanism that promotes sickling in this condition.

title: Clinical and hematological features of XXXX in Rio de Janeiro, Brazil.

answer: @entity5


abstract: Between 1981 and 1985, seven @entity0 (mean age 44 years) underwent surgery for benign gastroduodenal ulcer in the Department of Surgery. Cantonal Hospital, Fribourg, Switzerland. Surgical indications were a double subcardial and prepyloric ulcer recurring after medical treatment, a duodenal and jejunal anastomotic ulcer after gastroenterostomy, two duodenal @entity6 which recurred after vagotomy, and three perforated @entity6 (subcardial, prepyloric, duodenal). All @entity0 underwent two-thirds gastrectomy with a Roux-en-Y loop. Clinical investigations and gastroscopy were performed 1-5 years postoperatively. Clinical results were excellent in 5 cases (Visick 1), good in one (Visick 2), and moderate in one (Visick 3). Symptoms and signs associated with @entity2 were found as follows: @entity4 1 @entity0 ; @entity1 1 @entity0 ; weight loss 1 @entity0 ; @entity5 1 @entity0 . No bile staining was seen in any @entity0 . Gastric biopsy demonstrated a normal mucosa in 2 @entity0 and @entity7 in 5 @entity0 . Roux-en-Y gastrectomy gives satisfactory results in certain benign gastroduodenal ulcer situations. @entity3 may exist without biliary reflux.

title: [Clinical study and gastroscopy of XXXX following gastric resection and Roux-en-Y anastomosis].

answer: @entity2


abstract: @entity0 were delivered by Caesarean section in 128 cases during the early months of 1984. All animals were allocated alternately to a trial group and a group of controls. When the peritoneum and transverse muscle had been sutured, the wounds of the animals in the trial group were irrigated and washed with 300 ml. of @entity4 (10 per cent of @entity4 in water). This was followed by closure of the wound. The animals of the group of controls were not treated. The procedure was performed in ninety-four primiparae (73 per cent) and thirty-four multiparae (27 per cent). The indication for Caesarean section consisted in fetal oversize in 119 cases (93 per cent). Eight @entity0 (6 per cent) were stillborn or died immediately post partum. The proportion of animals in which the placentae were retained, was 9 per cent. Two animals died from @entity1 and @entity2 respectively. Irrigation of the wound did not have any effect on the number of wound infections (Table 3). @entity3 occurred in nineteen animals (15 per cent). The operations were performed by six veterinary surgeons (Table 4). The trial group and group of controls treated by each veterinarian did not differ essentially as regards wound healing.

title: [Wound healing and wound irrigation in cesarean section of XXXX ].

answer: @entity0


abstract: Terminal ileum was autografted (24 @entity2 ) or allografted (18 @entity2 ) as a 100-cm Thiry-Vella segment, and absorption, motility, and histology were studied. @entity2 with allografts were given @entity1 (CsA) 20 mg/kg/day. At a second operation 5 to 6 weeks after transplantation continuity of the nontransplanted intestine with the Thiry-Vella segment was restored. At a third operation 3 months after autografting, all the non-transplanted small intestine was excised. All technically successful autografts survived indefinitely, and the @entity2 weights were maintained at 88 +/- 0.6% (mean +/- SE) of preoperative weights by absorption from the autografted intestine. Administration of @entity1 to @entity2 with intestinal autografts produced a reversible impairment of intestinal absorption. @entity2 with allografts survived 63.3 +/- 15.5 days (mean +/- SE). @entity0 within 9 weeks of transplantation was from peritonitis secondary to graft rejection. @entity0 in long survivors was a consequence of inadequate intestinal absorption. In the first 4 weeks after transplantation absorption and motility of allografted Thiry-Vella segments was comparable to the intestinal autografts but allografts showed evidence of a @entity3 . Large volumes of high protein-content fluid were lost from the allografted Thiry-Vella segments, and @entity2 with allografts became hypoalbuminemic.

title: Segmental small intestinal allografts. II. Inadequate function with XXXX immunosuppression: evidence of a @entity3 .

answer: @entity1


abstract: Terminal ileum was autografted (24 @entity2 ) or allografted (18 @entity2 ) as a 100-cm Thiry-Vella segment, and absorption, motility, and histology were studied. @entity2 with allografts were given @entity1 (CsA) 20 mg/kg/day. At a second operation 5 to 6 weeks after transplantation continuity of the nontransplanted intestine with the Thiry-Vella segment was restored. At a third operation 3 months after autografting, all the non-transplanted small intestine was excised. All technically successful autografts survived indefinitely, and the @entity2 weights were maintained at 88 +/- 0.6% (mean +/- SE) of preoperative weights by absorption from the autografted intestine. Administration of @entity1 to @entity2 with intestinal autografts produced a reversible impairment of intestinal absorption. @entity2 with allografts survived 63.3 +/- 15.5 days (mean +/- SE). @entity0 within 9 weeks of transplantation was from peritonitis secondary to graft rejection. @entity0 in long survivors was a consequence of inadequate intestinal absorption. In the first 4 weeks after transplantation absorption and motility of allografted Thiry-Vella segments was comparable to the intestinal autografts but allografts showed evidence of a @entity3 . Large volumes of high protein-content fluid were lost from the allografted Thiry-Vella segments, and @entity2 with allografts became hypoalbuminemic.

title: Segmental small intestinal allografts. II. Inadequate function with @entity1 immunosuppression: evidence of a XXXX .

answer: @entity3


abstract: @entity4 bladders were distended for 4 h at 100 cm H2O to study the effects of distension on bladder function and structure. A micturition study was performed before overstretching, immediately after distension and 5 days after it. Bladder function was impaired immediately after distension, compliance and residual urine were increased and the maximum pressure during voiding decreased. The function returned to normal after 5 days. Overstretching caused @entity5 , only rarely @entity3 or @entity1 of bladder wall. Electron microscopic changes of the bladder peripheral nerves were slight, the consistent finding being @entity0 in areas of outer mesoaxons and between cytoplasmic processes of Schwann cells. This change was sometimes accompanied by a rupture of the surrounding basement membrane. Axonal lysis was observed in one case. It is concluded that these anatomical changes, although found at the moment of functional recovery, may be linked to @entity2 in the bladder wall causing, at least partly, its impaired function. This may further decrease @entity6 and after urinary retention cause prolonged micturition problems. Functional recovery occurs, however, quite rapidly in healthy bladders.

title: Effect of distension on function and nervous ultrastructure in the XXXX urinary bladder.

answer: @entity4


abstract: BACKGROUND: The long-term effects of ganglionated plexi ablation on electrophysiological characteristics and neuron remodeling in target atrial tissues remain unclear. METHODS AND RESULTS: @entity0 in group 1 (control, n=8) were not subjected to ganglionated plexi ablation and observed for 1 month, and @entity0 in groups 2 to 4 (ablation groups, n=8 each) underwent ablation of the right-sided ganglionated plexi and observed for 1, 6, and 12 months, respectively. Atrial electrophysiological characteristics were examined before ablation, immediately and continuously after ablation. Target atrial tissues were subjected to immunohistochemical staining and Western blot analysis. Atrial effective refractory period was significantly prolonged immediately after ablation (P<0.001), and persisted for 1 month (P<0.05). Nerve densities decreased 1 month after ablation (P<0.001). These parameters reverted to preablation levels after 6 and 12 months. In the ablation groups, @entity2 was induced in 5 of 8 @entity0 after 1 month and in all animals after 6 and 12 months. @entity2 was not observed in the control group and in the experimental groups immediately after ablation. Moreover, the expression of the @entity3 was upregulated after ablation. CONCLUSIONS: Ganglionated plexi ablation effectively prolonged atrial effective refractory period for a short period, but the long-term effects on atrial effective refractory period and the suppression of @entity2 induction were not persistent. Targeted @entity1 may be an important mechanism underlying the observed electrophysiological changes.

title: Long-Term Effects of Ganglionated Plexi Ablation on Electrophysiological Characteristics and Neuron Remodeling in Target Atrial Tissues in a XXXX Model.

answer: @entity0


abstract: UNASSIGNED: Protein @entity4 methyltransferases (PRMTs) plays critical roles in @entity1 . @entity9 has been implicated in several types of @entity1 . However, the role of @entity9 in @entity1 development remains to be fully elucidated. Here, we provide evidence that @entity9 is overexpressed in @entity2 ( @entity2 ) cells and @entity0 -derived @entity1 , correlated with increased cell growth and decreased overall @entity0 survival. @entity4 methyltransferase inhibitor 1 (AMI-1)strongly inhibited @entity1 growth, increased the ratio of @entity6 / @entity5 , and induced apoptosis in @entity3 @entity2 xenograt model. AMI-1 also induced apoptosis and decreased the migratory activity in several @entity2 cells. In @entity2 xenografts AMI-1 significantly decreased symmetric dimethylation of histone 4 (H4R3me2s), a histone mark of type II @entity9 , but not the expression of H4R3me2a, a histone mark of type I PRMTs. These results suggest that the inhibition of @entity9 contributes to the antitumor efficacy of AMI-1. Chromatin immunoprecipitation (ChIP) identified @entity7 and @entity8 as two key genes regulated by @entity9 . @entity9 knockdown reduced the levels of H4R3me2s and H3R8me2s methylation on @entity7 and @entity8 promoters, leading to decreased expressions of @entity7 and @entity8 . Collectively, our findings provide new evidence that @entity9 plays an important role in @entity2 pathogenesis through epigenetically regulating @entity4 methylation of oncogenes such as @entity8 and @entity7 .

title: Targeting protein @entity4 methyltransferase 5 inhibits XXXX growth by decreasing @entity4 methylation of @entity8 and @entity7 .

answer: @entity2


abstract: UNASSIGNED: Protein @entity4 methyltransferases (PRMTs) plays critical roles in @entity1 . @entity9 has been implicated in several types of @entity1 . However, the role of @entity9 in @entity1 development remains to be fully elucidated. Here, we provide evidence that @entity9 is overexpressed in @entity2 ( @entity2 ) cells and @entity0 -derived @entity1 , correlated with increased cell growth and decreased overall @entity0 survival. @entity4 methyltransferase inhibitor 1 (AMI-1)strongly inhibited @entity1 growth, increased the ratio of @entity6 / @entity5 , and induced apoptosis in @entity3 @entity2 xenograt model. AMI-1 also induced apoptosis and decreased the migratory activity in several @entity2 cells. In @entity2 xenografts AMI-1 significantly decreased symmetric dimethylation of histone 4 (H4R3me2s), a histone mark of type II @entity9 , but not the expression of H4R3me2a, a histone mark of type I PRMTs. These results suggest that the inhibition of @entity9 contributes to the antitumor efficacy of AMI-1. Chromatin immunoprecipitation (ChIP) identified @entity7 and @entity8 as two key genes regulated by @entity9 . @entity9 knockdown reduced the levels of H4R3me2s and H3R8me2s methylation on @entity7 and @entity8 promoters, leading to decreased expressions of @entity7 and @entity8 . Collectively, our findings provide new evidence that @entity9 plays an important role in @entity2 pathogenesis through epigenetically regulating @entity4 methylation of oncogenes such as @entity8 and @entity7 .

title: Targeting protein @entity4 methyltransferase 5 inhibits @entity2 growth by decreasing @entity4 methylation of @entity8 and XXXX .

answer: @entity7


abstract: UNASSIGNED: Protein @entity4 methyltransferases (PRMTs) plays critical roles in @entity1 . @entity9 has been implicated in several types of @entity1 . However, the role of @entity9 in @entity1 development remains to be fully elucidated. Here, we provide evidence that @entity9 is overexpressed in @entity2 ( @entity2 ) cells and @entity0 -derived @entity1 , correlated with increased cell growth and decreased overall @entity0 survival. @entity4 methyltransferase inhibitor 1 (AMI-1)strongly inhibited @entity1 growth, increased the ratio of @entity6 / @entity5 , and induced apoptosis in @entity3 @entity2 xenograt model. AMI-1 also induced apoptosis and decreased the migratory activity in several @entity2 cells. In @entity2 xenografts AMI-1 significantly decreased symmetric dimethylation of histone 4 (H4R3me2s), a histone mark of type II @entity9 , but not the expression of H4R3me2a, a histone mark of type I PRMTs. These results suggest that the inhibition of @entity9 contributes to the antitumor efficacy of AMI-1. Chromatin immunoprecipitation (ChIP) identified @entity7 and @entity8 as two key genes regulated by @entity9 . @entity9 knockdown reduced the levels of H4R3me2s and H3R8me2s methylation on @entity7 and @entity8 promoters, leading to decreased expressions of @entity7 and @entity8 . Collectively, our findings provide new evidence that @entity9 plays an important role in @entity2 pathogenesis through epigenetically regulating @entity4 methylation of oncogenes such as @entity8 and @entity7 .

title: Targeting protein @entity4 methyltransferase 5 inhibits @entity2 growth by decreasing @entity4 methylation of XXXX and @entity7 .

answer: @entity8


abstract: UNASSIGNED: Protein @entity4 methyltransferases (PRMTs) plays critical roles in @entity1 . @entity9 has been implicated in several types of @entity1 . However, the role of @entity9 in @entity1 development remains to be fully elucidated. Here, we provide evidence that @entity9 is overexpressed in @entity2 ( @entity2 ) cells and @entity0 -derived @entity1 , correlated with increased cell growth and decreased overall @entity0 survival. @entity4 methyltransferase inhibitor 1 (AMI-1)strongly inhibited @entity1 growth, increased the ratio of @entity6 / @entity5 , and induced apoptosis in @entity3 @entity2 xenograt model. AMI-1 also induced apoptosis and decreased the migratory activity in several @entity2 cells. In @entity2 xenografts AMI-1 significantly decreased symmetric dimethylation of histone 4 (H4R3me2s), a histone mark of type II @entity9 , but not the expression of H4R3me2a, a histone mark of type I PRMTs. These results suggest that the inhibition of @entity9 contributes to the antitumor efficacy of AMI-1. Chromatin immunoprecipitation (ChIP) identified @entity7 and @entity8 as two key genes regulated by @entity9 . @entity9 knockdown reduced the levels of H4R3me2s and H3R8me2s methylation on @entity7 and @entity8 promoters, leading to decreased expressions of @entity7 and @entity8 . Collectively, our findings provide new evidence that @entity9 plays an important role in @entity2 pathogenesis through epigenetically regulating @entity4 methylation of oncogenes such as @entity8 and @entity7 .

title: Targeting protein XXXX methyltransferase 5 inhibits @entity2 growth by decreasing @entity4 methylation of @entity8 and @entity7 .

answer: @entity4


abstract: UNASSIGNED: Protein @entity4 methyltransferases (PRMTs) plays critical roles in @entity1 . @entity9 has been implicated in several types of @entity1 . However, the role of @entity9 in @entity1 development remains to be fully elucidated. Here, we provide evidence that @entity9 is overexpressed in @entity2 ( @entity2 ) cells and @entity0 -derived @entity1 , correlated with increased cell growth and decreased overall @entity0 survival. @entity4 methyltransferase inhibitor 1 (AMI-1)strongly inhibited @entity1 growth, increased the ratio of @entity6 / @entity5 , and induced apoptosis in @entity3 @entity2 xenograt model. AMI-1 also induced apoptosis and decreased the migratory activity in several @entity2 cells. In @entity2 xenografts AMI-1 significantly decreased symmetric dimethylation of histone 4 (H4R3me2s), a histone mark of type II @entity9 , but not the expression of H4R3me2a, a histone mark of type I PRMTs. These results suggest that the inhibition of @entity9 contributes to the antitumor efficacy of AMI-1. Chromatin immunoprecipitation (ChIP) identified @entity7 and @entity8 as two key genes regulated by @entity9 . @entity9 knockdown reduced the levels of H4R3me2s and H3R8me2s methylation on @entity7 and @entity8 promoters, leading to decreased expressions of @entity7 and @entity8 . Collectively, our findings provide new evidence that @entity9 plays an important role in @entity2 pathogenesis through epigenetically regulating @entity4 methylation of oncogenes such as @entity8 and @entity7 .

title: Targeting protein @entity4 methyltransferase 5 inhibits @entity2 growth by decreasing XXXX methylation of @entity8 and @entity7 .

answer: @entity4


abstract: After a brief review of the literature, the results of the treatment by radiation therapy in 218 @entity0 with tonsillar region @entity2 are reported. The @entity0 were treated at the Turin University Radiotherapy Department (131 cases) and at the Radiotherapy Department of the Ospedale Maggiore, Novara (87 cases) from 1976 through 1984. The series included 29 T1, 88 T2, 64 T3 and 37 T4; 86 @entity0 (40%) were N0. Only 49 @entity0 were stages I and II (1/4 of the total). The local control (T) rate at the end of therapy was 63.5% for the overall series (139/218) ranging from 100% in T1, 72.6% T2, 54.6% T3 to 30% T4; the regional control (N) for @entity0 with cervical @entity4 was 66% (88/132). The overall 5-year survival was 38%; the 5-year disease-free survival was 35%. The 5-year survival according to T-stage was 52% for limited cases ( @entity5 ) in comparison to 22% for advanced ones (T3-T4). The 5-year survival for N0 stage was 55%; when neck nodes were present (N # 0) the survival was 29% after 5 years. Complications included 6 cases of trismus and 2 osteonecroses of the mandible. Second primary @entity1 were seen in 17 cases (7.8%). The most common cause of @entity3 was failure in primary @entity1 control (80% of cases). In this series the results of radiotherapy of @entity1 are quite good; @entity0 with large @entity1 masses fare less satisfactorily. Better results should be obtained in the future by identifying prognostic factors, monitoring potential causes of treatment failure and optimizing the radiotherapeutic treatment plan and technique.

title: [Results of radiotherapy in the treatment of 218 XXXX of the tonsillar area].

answer: @entity2


abstract: OBJECTIVE: To investigate the feasibility and the mid-term effects of unilateral pedicle screw fixation and transforaminal lumbar interbody fusion in treating @entity1 . METHODS: From August 2005 to May 2010, 56 @entity0 with @entity1 underwent lumbar posterolateral fusion,their clinical data were retrospective analyzed. The @entity0 were divided into two groups (unilateral group and bilateral group) according to fixation methods,27 @entity0 in unilateral group who were underwent unilateral pedicle screw fixation, including 18 males and 9 females with a mean age of (57.5    7.1) years old (ranged from 41 to 66 years); and 29 @entity0 in bilateral group who were treated with bilateral pedicle screw fixation (on the basis of the above, with contralateral vertebral pedicle screw fixation), including 19 males and 10 females with a mean age of (54.6    5.1) years old (ranged from 43 to 68 years). The clinical data such as operation time, @entity2 volume, hospitalization time and cost were compared between two groups. JOA score system was used to evaluate the neurological function. And fusion status and cage-related complication were also analyzed. RESULTS: All @entity0 were followed up from 36 to 60 months with an average of 45.8 months. No @entity3 were found during operation. Operation time, @entity2 volume, hospitalization time and cost in unilateral group were better than that of bilateral group (P < 0.05). There was no significant difference in JOA score between two groups (P > 0.05). Two @entity0 in unilateral group developed with cage related complications, 1 case was cage displacement and 1 case was cage subsidence, while 2 @entity0 in bilateral group developed with complications of no-fusion, and there was no significant differences between two groups (P = 0.58). CONCLUSION: Unilateral pedicle screw fixation is a satisfactory method and can obtain good effects in treating @entity1 in mid-term, however, the indications should be well considered.

title: [Mid-term effect of unilateral pedicle screw fixation and transforaminal lumbar interbody fusion in the treatment of XXXX ].

answer: @entity1


abstract: OBJECTIVE: To evaluate the clinical effects of single posterior debridement, bone grafting, internal fixation and local chemotherapy in treating thoracolumbar @entity6 . METHODS: From February 2009 to September 2012,11 @entity0 with thoracolumbar @entity6 were treated by single posterior debridement, bone grafting, internal fixation and local chemotherapy. There were 7 males and 4 females, aged from 27 to 65 years old with an average of 53.7 years. The courses of disease was from 3 months to 2 years with the mean of 9 months. According to ASIA standard of @entity4 , 3 cases were grade C and 8 cases D. After treatment, clinical effects were evaluated by ASIA grade, visual analogue score (VAS) and @entity3 Index (ODI); kyphosis Cobb angle change was observed by X-rays. RESULTS: Eleven @entity0 were followed up from 12 to 29 months with an average of 18 months. ASIA grade of @entity4 , 3 @entity0 with grade C improved to grade D in 2 cases and grade E in 1 case 8 @entity0 with grade D improved to grade E in 7 cases and unchanged in 1 case. VAS decreased from preoperative 6.10    1.30 to 1.70    0.80 at 3 d after operation (P < 0.05). ODI improved from preoperative (68.36    10.41)% to (14.55    8.99)% (P < 0.05) at 3 d after operation. Kyphotic Cobb angle was corrected from preoperative (22.64    4.84)   to (4.27    1.49)   (P < 0.05) on the 3rd day after operation, and angle loss was mild at final follow-up, there was no significant difference between postoperative at 3 d and final follow-up. CONCLUSION: Single posterior debridement, bone grafting, internal fixation and local chemotherapy for the treatment of thoracolumbar @entity6 can effectively remove the lesion, improve nerve function and @entity1 , has advantage of single incision, @entity2 , and low recurrence rate. But it still need long-term and systemic treatment with anti- @entity5 drugs.

title: [Treatment of thoracolumbar XXXX with single posterior debridement, bone grafting, internal fixation and local chemotherapy].

answer: @entity6


abstract: BACKGROUND: Over 2.5 billion @entity0 are exposed to the risk of contracting @entity2 ( @entity2 ). Early diagnosis of @entity2 helps to diminish its burden on public health. Real-time reverse transcription polymerase amplification assays (RT-PCR) are the standard method for molecular detection of the dengue virus (DENV). Real-time RT-PCR analysis is not suitable for on-site screening since mobile devices are large, expensive, and complex. In this study, two RT-recombinase polymerase amplification (RT-RPA) assays were developed to detect DENV1-4. METHODOLOGY/PRINCIPAL FINDINGS: Using two quantitative RNA molecular standards, the analytical sensitivity of a RT-RPA targeting the 3  non-translated region of DENV1-4 was found to range from 14 (DENV4) to 241 (DENV1-3) RNA molecules detected. The assay was specific and did not cross detect other Flaviviruses. The RT-RPA assay was tested in a mobile laboratory combining magnetic-bead based total nucleic acid extraction and a portable detection device in Kedougou (Senegal) and in Bangkok (Thailand). In Kedougou, the RT-RPA was operated at an ambient temperature of 38  C with auxiliary electricity tapped from a motor vehicle and yielded a clinical sensitivity and specificity of 98% (n=31) and 100% (n=23), respectively. While in the field trial in Bangkok, the clinical sensitivity and specificity were 72% (n=90) and 100%(n=41), respectively. CONCLUSIONS/SIGNIFICANCE: During the first 5 days of @entity1 , the developed DENV1-4 RT-RPA assays constitute a suitable accurate and rapid assay for DENV diagnosis. Moreover, the use of a portable fluorescence-reading device broadens its application potential to the point-of-care for outbreak investigations.

title: Recombinase Polymerase Amplification Assay for Rapid Diagnostics of XXXX .

answer: @entity1


abstract: BACKGROUND: In March 2012, the Xpert MTB/RIF assay (Xpert) was introduced in three provincial public hospitals in Indonesia as a novel diagnostic to detect @entity1 and @entity2 resistance among high risk individuals. OBJECTIVE: This study assessed the effects of using Xpert in place of conventional solid and liquid culture and drug-susceptibility testing on case detection rates, treatment initiation rates, and health system delays among @entity3 ( @entity1 ) @entity0 . METHODS: Cohort data on registration, test results and treatment initiation were collected from routine presumptive @entity0 registers one year before and one year after Xpert was introduced. Proportions of case detection and treatment initiation were compared using the Pearson Chi square test and median time delays using the Mood's Median test. RESULTS: A total of 975 individuals at risk of @entity3 were registered in the pre-intervention year and 1,442 in the post-intervention year. After Xpert introduction, @entity1 positivity rate increased by 15%, while @entity2 resistance rate reduced by 23% among @entity1 positive cases and by 9% among all tested. Second-line @entity1 treatment initiation rate among @entity2 resistant @entity0 increased by 19%. Time from client registration to diagnosis was reduced by 74 days to a median of a single day (IQR 0-4) and time from diagnosis to treatment start was reduced by 27 days to a median of 15 days (IQR 7-51). All findings were significant with p<0.001. CONCLUSION: Compared to solid and liquid culture and drug-susceptibility testing, Xpert detected more @entity1 and less @entity2 resistance, increased second-line treatment initiation rates and shortened time to diagnosis and treatment. This test holds promise to improve rapid case finding and management of @entity3 @entity0 in Indonesia.

title: Effects of Introducing Xpert MTB/RIF on Diagnosis and Treatment of XXXX @entity0 in Indonesia: A Pre-Post Intervention Study.

answer: @entity3


abstract: BACKGROUND: In March 2012, the Xpert MTB/RIF assay (Xpert) was introduced in three provincial public hospitals in Indonesia as a novel diagnostic to detect @entity1 and @entity2 resistance among high risk individuals. OBJECTIVE: This study assessed the effects of using Xpert in place of conventional solid and liquid culture and drug-susceptibility testing on case detection rates, treatment initiation rates, and health system delays among @entity3 ( @entity1 ) @entity0 . METHODS: Cohort data on registration, test results and treatment initiation were collected from routine presumptive @entity0 registers one year before and one year after Xpert was introduced. Proportions of case detection and treatment initiation were compared using the Pearson Chi square test and median time delays using the Mood's Median test. RESULTS: A total of 975 individuals at risk of @entity3 were registered in the pre-intervention year and 1,442 in the post-intervention year. After Xpert introduction, @entity1 positivity rate increased by 15%, while @entity2 resistance rate reduced by 23% among @entity1 positive cases and by 9% among all tested. Second-line @entity1 treatment initiation rate among @entity2 resistant @entity0 increased by 19%. Time from client registration to diagnosis was reduced by 74 days to a median of a single day (IQR 0-4) and time from diagnosis to treatment start was reduced by 27 days to a median of 15 days (IQR 7-51). All findings were significant with p<0.001. CONCLUSION: Compared to solid and liquid culture and drug-susceptibility testing, Xpert detected more @entity1 and less @entity2 resistance, increased second-line treatment initiation rates and shortened time to diagnosis and treatment. This test holds promise to improve rapid case finding and management of @entity3 @entity0 in Indonesia.

title: Effects of Introducing Xpert MTB/RIF on Diagnosis and Treatment of @entity3 XXXX in Indonesia: A Pre-Post Intervention Study.

answer: @entity0


abstract: BACKGROUND: Very rapidly progressive " @entity2 " was observed prior to the 1930 International Labour Office Conference on @entity5 , but its clinical significance and pathologic relationship to classic @entity3 caused @entity4 were not settled. METHODS: Textual analysis of the 1930 Conference proceedings identified data relevant to rapidly progressive @entity5 . Standard bibliographic searches identified relevant biomedical literature dating from before and after the Conference. RESULTS: The 1930 Johannesburg Conference contained descriptions of @entity2 , especially in the abrasive powders industry, but acute @entity3 -related @entity0 did not conform to a three-stage disease model in @entity1 caused advanced disease, a model accepted at the Conference. Over following decades, additional reports appeared of rapidly progressive @entity5 , unrelated to @entity1 . @entity6 was identified only in 1958. CONCLUSIONS: Adoption by the 1930 Johannesburg Conference of a classification scheme into which acute rapidly progressive disease unrelated to @entity1 fitted poorly may have impeded the understanding of @entity2 and its importance. Am. J. Ind. Med. 58:S39-S47, 2015.    2015 Wiley Periodicals, Inc.

title: "Acute" XXXX at the 1930 Johannesburg Conference on @entity5 and in its aftermath: Controversies over a distinct entity later recognized as silicoproteinosis.

answer: @entity5


abstract: BACKGROUND: Very rapidly progressive " @entity2 " was observed prior to the 1930 International Labour Office Conference on @entity5 , but its clinical significance and pathologic relationship to classic @entity3 caused @entity4 were not settled. METHODS: Textual analysis of the 1930 Conference proceedings identified data relevant to rapidly progressive @entity5 . Standard bibliographic searches identified relevant biomedical literature dating from before and after the Conference. RESULTS: The 1930 Johannesburg Conference contained descriptions of @entity2 , especially in the abrasive powders industry, but acute @entity3 -related @entity0 did not conform to a three-stage disease model in @entity1 caused advanced disease, a model accepted at the Conference. Over following decades, additional reports appeared of rapidly progressive @entity5 , unrelated to @entity1 . @entity6 was identified only in 1958. CONCLUSIONS: Adoption by the 1930 Johannesburg Conference of a classification scheme into which acute rapidly progressive disease unrelated to @entity1 fitted poorly may have impeded the understanding of @entity2 and its importance. Am. J. Ind. Med. 58:S39-S47, 2015.    2015 Wiley Periodicals, Inc.

title: "Acute" @entity5 at the 1930 Johannesburg Conference on XXXX and in its aftermath: Controversies over a distinct entity later recognized as silicoproteinosis.

answer: @entity5


abstract: X-rays of the hands and wrists of 100 @entity0 suffering from @entity4 ( @entity4 ) were compared to those of 65 control subjects matched for age and sex. Osteoarticular destruction was assessed using Larsen's index and by carpal @entity2 ; ulnar deviation of the fingers (UDF) and @entity2 ( @entity2 ). No significant asymmetry of lesions in the right or left hands can be demonstrated, whatever the subsets of @entity0 and osteoarticular manifestations studied. After a one year course, there is no significant difference between @entity0 and control subjects. Only the index of @entity3 is significantly high and the clinical course progresses between 1 and 5 years (p = 0.02). The difference becomes significant for UDF (p less than 0.01) after the disease evolves for 5 to 10 yrs. UDF is correlated with @entity1 (p = 0.01) and metacarpophalangeal lesions (MCP). Different @entity1 of the hand are correlated with each other. The close correlation between UDF and @entity2 and MCP involvement has been confirmed by various statistical tests. Comparison of seropositive and seronegative @entity0 with @entity4 only reveals a more marked disturbance of MCP in the seropositive @entity0 . Various methods of assessing @entity3 and joint destruction are discussed. Finally, the etiopathogenic mechanisms causing deformities of the hand in @entity4 were studied, and the authors reviewed the importance of the initial involvement of soft tissues and therapeutic implications whereby prevention of disease extension using prompt local therapy is recommended.

title: [Radiographic study of the XXXX and etiopathogenic mechanisms of deformities. Apropos of 100 cases].

answer: @entity4


abstract: The morphologic features of 307 @entity7 among 159 @entity0 are reviewed. Most @entity5 (66.4%) were located in the sigmoid colon and the rectum, and the percentage decreased proximally to the right colon. The 307 @entity5 comprised 244 (79.5%) tubular, 41 (13.3%) tubulovillous, and 22 (7.2%) @entity9 . The @entity8 was graded as mild in 260 (84.7%) @entity5 , moderate in 33 (10.7%), and severe in 14 (4.6%). The percentage of severe @entity6 was greater in @entity9 than in tubular @entity5 (p less than 0.05) and correlated with the increasing size (greater than 5 mm) of the @entity5 (p less than 0.01). The risk of @entity5 could be evaluated among 56 @entity0 , 34 @entity0 and 22 @entity0 with a history of removed @entity5 (s). Fourteen of 56 @entity0 (25%) with 6:1 male to female ratio developed 18 new @entity5 , after an average of 34.3 months (range, from 12 to 88 months). Eleven of the 14 @entity0 had multiple @entity5 at the initial examination. In addition, a @entity2 was found in one male @entity0 . Of the 48 @entity0 , 17 @entity0 and 31 @entity0 , operated on for @entity1 16 @entity0 (34%) with 1.3:1 male to female ratio had 40 new @entity5 after an average of 51.8 months (range, 12 to 252 months) after the surgical excision of their @entity3 . One @entity0 had a recurrent @entity3 at the site of the @entity4 22 months after anterior resection of his @entity3 . Our data suggest that a history of @entity1 , multiple @entity5 , and male sex predict a higher risk of having future @entity1 .

title: XXXX : morphologic features and the risk of developing @entity5 and @entity3 in the colorectum.

answer: @entity7


abstract: The morphologic features of 307 @entity7 among 159 @entity0 are reviewed. Most @entity5 (66.4%) were located in the sigmoid colon and the rectum, and the percentage decreased proximally to the right colon. The 307 @entity5 comprised 244 (79.5%) tubular, 41 (13.3%) tubulovillous, and 22 (7.2%) @entity9 . The @entity8 was graded as mild in 260 (84.7%) @entity5 , moderate in 33 (10.7%), and severe in 14 (4.6%). The percentage of severe @entity6 was greater in @entity9 than in tubular @entity5 (p less than 0.05) and correlated with the increasing size (greater than 5 mm) of the @entity5 (p less than 0.01). The risk of @entity5 could be evaluated among 56 @entity0 , 34 @entity0 and 22 @entity0 with a history of removed @entity5 (s). Fourteen of 56 @entity0 (25%) with 6:1 male to female ratio developed 18 new @entity5 , after an average of 34.3 months (range, from 12 to 88 months). Eleven of the 14 @entity0 had multiple @entity5 at the initial examination. In addition, a @entity2 was found in one male @entity0 . Of the 48 @entity0 , 17 @entity0 and 31 @entity0 , operated on for @entity1 16 @entity0 (34%) with 1.3:1 male to female ratio had 40 new @entity5 after an average of 51.8 months (range, 12 to 252 months) after the surgical excision of their @entity3 . One @entity0 had a recurrent @entity3 at the site of the @entity4 22 months after anterior resection of his @entity3 . Our data suggest that a history of @entity1 , multiple @entity5 , and male sex predict a higher risk of having future @entity1 .

title: @entity7 : morphologic features and the risk of developing @entity5 and XXXX in the colorectum.

answer: @entity3


abstract: The morphologic features of 307 @entity7 among 159 @entity0 are reviewed. Most @entity5 (66.4%) were located in the sigmoid colon and the rectum, and the percentage decreased proximally to the right colon. The 307 @entity5 comprised 244 (79.5%) tubular, 41 (13.3%) tubulovillous, and 22 (7.2%) @entity9 . The @entity8 was graded as mild in 260 (84.7%) @entity5 , moderate in 33 (10.7%), and severe in 14 (4.6%). The percentage of severe @entity6 was greater in @entity9 than in tubular @entity5 (p less than 0.05) and correlated with the increasing size (greater than 5 mm) of the @entity5 (p less than 0.01). The risk of @entity5 could be evaluated among 56 @entity0 , 34 @entity0 and 22 @entity0 with a history of removed @entity5 (s). Fourteen of 56 @entity0 (25%) with 6:1 male to female ratio developed 18 new @entity5 , after an average of 34.3 months (range, from 12 to 88 months). Eleven of the 14 @entity0 had multiple @entity5 at the initial examination. In addition, a @entity2 was found in one male @entity0 . Of the 48 @entity0 , 17 @entity0 and 31 @entity0 , operated on for @entity1 16 @entity0 (34%) with 1.3:1 male to female ratio had 40 new @entity5 after an average of 51.8 months (range, 12 to 252 months) after the surgical excision of their @entity3 . One @entity0 had a recurrent @entity3 at the site of the @entity4 22 months after anterior resection of his @entity3 . Our data suggest that a history of @entity1 , multiple @entity5 , and male sex predict a higher risk of having future @entity1 .

title: @entity7 : morphologic features and the risk of developing XXXX and @entity3 in the colorectum.

answer: @entity5


abstract: UNASSIGNED: Quantifying binding specificity and drug resistance of protein kinase inhibitors is of fundamental importance and remains highly challenging due to complex interplay of structural and thermodynamic factors. In this work, molecular simulations and computational @entity0 scanning are combined with the network-based approaches to characterize molecular determinants underlying binding specificities of the @entity3 kinase inhibitors. The proposed theoretical framework unveiled a relationship between ligand binding and inhibitor-mediated changes in the residue interaction networks. By using topological parameters, we have described the organization of the residue interaction networks and networks of coevolving residues in the @entity3 kinase structures. This analysis has shown that functionally critical regulatory residues can simultaneously embody strong coevolutionary signal and high network centrality with a propensity to be energetic hot spots for drug binding. We have found that selective ( @entity2 ) and promiscuous ( @entity4 , @entity1 ) kinase inhibitors can use their energetic hot spots to differentially modulate stability of the residue interaction networks, thus inhibiting or promoting conformational equilibrium between inactive and active states. According to our results, @entity2 binding may induce a significant network-bridging effect and enhance centrality of the hot spot residues that stabilize structural environment favored by the specific kinase form. In contrast, @entity4 and @entity1 can incur modest changes in the residue interaction network in which ligand binding is primarily coupled only with the identity of the gate-keeper residue. These factors may promote structural adaptability of the active kinase states in binding with these promiscuous inhibitors. Our results have related ligand-induced changes in the residue interaction networks with drug resistance effects, showing that network robustness may be compromised by targeted mutations of key mediating residues. This study has outlined mechanisms by which inhibitor binding could modulate resilience and efficiency of allosteric interactions in the kinase structures, while preserving structural topology required for catalytic activity and regulation.

title: Molecular Determinants Underlying Binding Specificities of the @entity3 Kinase Inhibitors: Combining XXXX Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution.

answer: @entity0


abstract: UNASSIGNED: Quantifying binding specificity and drug resistance of protein kinase inhibitors is of fundamental importance and remains highly challenging due to complex interplay of structural and thermodynamic factors. In this work, molecular simulations and computational @entity0 scanning are combined with the network-based approaches to characterize molecular determinants underlying binding specificities of the @entity3 kinase inhibitors. The proposed theoretical framework unveiled a relationship between ligand binding and inhibitor-mediated changes in the residue interaction networks. By using topological parameters, we have described the organization of the residue interaction networks and networks of coevolving residues in the @entity3 kinase structures. This analysis has shown that functionally critical regulatory residues can simultaneously embody strong coevolutionary signal and high network centrality with a propensity to be energetic hot spots for drug binding. We have found that selective ( @entity2 ) and promiscuous ( @entity4 , @entity1 ) kinase inhibitors can use their energetic hot spots to differentially modulate stability of the residue interaction networks, thus inhibiting or promoting conformational equilibrium between inactive and active states. According to our results, @entity2 binding may induce a significant network-bridging effect and enhance centrality of the hot spot residues that stabilize structural environment favored by the specific kinase form. In contrast, @entity4 and @entity1 can incur modest changes in the residue interaction network in which ligand binding is primarily coupled only with the identity of the gate-keeper residue. These factors may promote structural adaptability of the active kinase states in binding with these promiscuous inhibitors. Our results have related ligand-induced changes in the residue interaction networks with drug resistance effects, showing that network robustness may be compromised by targeted mutations of key mediating residues. This study has outlined mechanisms by which inhibitor binding could modulate resilience and efficiency of allosteric interactions in the kinase structures, while preserving structural topology required for catalytic activity and regulation.

title: Molecular Determinants Underlying Binding Specificities of the XXXX Kinase Inhibitors: Combining @entity0 Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution.

answer: @entity3


abstract: UNASSIGNED: Various methods of @entity3 ( @entity3 ) catheter insertion are available. The purpose of this study was to evaluate a percutaneous insertion technique using ultrasound (US) and fluoroscopy performed under conscious sedation and as day case procedure. Data of 87 percutaneous inserted dialysis catheters were prospectively collected, including @entity0 ' age, gender, body mass index, history of previous abdominal surgery and cause of end @entity2 . Length of hospital stay, early complications and time to first use were also recorded. Institutional review board approval was obtained. A 100% technical success rate was observed. Early complications included @entity5 (n   =   3), @entity4 (n   =   6), exit site infection (n   =   1) and exit site leakage (n   =   1). All cases of @entity4 and one case of @entity5 required surgical revision. Median time of follow-up was 18 months (range 3-35), and median time from insertion to first use was days 14 (1-47). Of the 82 @entity0 who started dialysis, 20 (23%) ceased @entity3 at some stage during follow-up. Most frequently encountered reasons include deteriorating @entity0 cognitive or functional status (n   =   5), successful transplant kidney (n   =   4) and @entity3 (n   =   4). Sixty-two (71%) @entity3 catheter insertions were performed as day case. The remaining insertions were performed on @entity0 already admitted to the hospital. Percutaneous insertion of dialysis catheter using US and fluoroscopy is not only safe but can be performed as day case procedure in most @entity0 , even with a medical history of abdominal surgery and/or @entity1 .

title: Percutaneous insertion of XXXX catheters using ultrasound and fluoroscopic guidance: A single centre experience and review of literature.

answer: @entity3