abstract: BACKGROUND: The appendix, considered an intestinal microbiota reservoir, may be protective against the risk of fulminant @entity2 @entity1 . METHODS: Retrospective analysis was performed in @entity0 with @entity2 @entity1 at St. Francis Medical Center from 2007 to 2011. Outcome of @entity1 and history of appendectomy were compared. Statistical analysis was by chi-square and multivariate logistic regression. RESULTS: In total, 507 @entity0 were hospitalized for @entity2 . Of 388 @entity0 with intact appendix, 20 (5.2%) developed fulminant @entity1 and required colectomy, whereas of 119 @entity0 with previous appendectomy, 13 (10.9%) required colectomy. An increased severity of disease, indicated by increased rate of colectomy, occurred for the group with a history of appendectomy (P = .03). Age and sex were adjusted by multivariant regression (P = .05). CONCLUSIONS: Appendectomy may be a risk factor for increased severity of @entity2 @entity1 . Although the mechanism is unknown, further studies are warranted.

title: Appendectomy: a risk factor for colectomy in XXXX with @entity2 .

answer: @entity0


abstract: Bronchoalveolar lavage is used to evaluate @entity1 in @entity0 with @entity3 . Normal values for lavage cell counts and proteins are derived primarily from young subjects who are free from @entity3 ; however, older @entity0 who undergo bronchoalveolar lavage often have used cigarettes for long periods of time and have developed variable degrees of chronic @entity5 and/or chronic air-flow obstruction. Therefore, we evaluated the effects of cigarette use, chronic @entity5 , and chronic air-flow obstruction on lavage cell populations by performing bronchoalveolar lavage in 48 male @entity0 who were undergoing diagnostic fiberoptic bronchoscopy. Sixteen @entity0 (33%) had elevated percentages of neutrophils (greater than or equal to 10%) in lavage fluid. Fourteen of these (87.5%) had chronic cough and/or phlegm production, but only 9 (64.3%) met criteria for definite chronic @entity5 . @entity0 with moderate or severe air-flow obstruction, defined spirometrically, had significantly greater percentages of lavage neutrophils and lower percentages of macrophages than did @entity0 with mild or no air-flow obstruction. The first lavage aliquot contained the greatest proportion of neutrophils and the smallest proportion of macrophages. The percentage of neutrophils declined and the percentage of macrophages increased in sequential aliquots. The data indicate that @entity0 with chronic cough and/or phlegm production and chronic air-flow obstruction may have increased proportions of neutrophils in bronchoalveolar lavage fluid in the absence of @entity4 or @entity2 . These variables must be taken into account when interpreting lavage cellular analyses.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The effects of chronic XXXX and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage.

answer: @entity5


abstract: OBJECTIVE: To observe and summarize the morphologic features that may suggest submucosal invasive @entity3 in colorectal mucosa biopsy specimens. METHODS: The study cohort included 432 colorectal biopsy specimens were obtained from 2006 to 2012. All the cases had radical surgery. Basing on the pathologic diagnoses, the cases were divided into 366 invasive @entity3 (IAC) and 66 @entity4 ( @entity4 ). These two groups were compared. RESULTS: In the IAC group, the percentage of @entity0 forming cribriform structures, acute angle-shaped glands, diffuse @entity2 cell proliferation was 61.2% (224/366) , 33.8% (124/366) and 7.4% (27/366) , respectively. In the @entity4 group, cribriform gland structures appeared in 6.0% (4/66) of the cases, while no acute angle-shaped gland or diffuse @entity2 cell proliferation was detected. The difference of these three characteristics in the two group was statistically significant (all P < 0.01). Glandular branching was detected in 89.9% (329/366) of IAC cases and 66.7% (44/66) of @entity4 cases; this difference was not significant. There was no difference in cellular atypia between the two groups. Interstitial @entity1 was detected more frequently in the IAC group (85.5%, 313/366 in IAC versus 0 in @entity4 , P < 0.01). In biopsy specimens of IAC, a few cases showed @entity0 in close contact with large lymphatics, adipose tissue, and @entity5 . CONCLUSIONS: In colorectal biopsy specimen, the five features that suggest submucosal invasion of the @entity0 including the formation of cribriform structure, angular gland, diffuse @entity2 cells, interstitial @entity1 and @entity0 in close contact with the thick-walled vessels.

title: [Morphologic features suggestive of submucosal invasive XXXX in colorectal mucosal biopsy specimens].

answer: @entity3


abstract: 1. Isometric contractions of fast and slow twitch muscles of @entity0 were recorded 1-42 days after denervation. 2. The major changes occurred over the period from 2 to 6 days after denervation. These changes were qualitatively similar in the two types of muscle. The most important effects were on the twitch: times to peak and half relaxation were prolonged, active @entity4 and peak rate of rise of @entity4 were increased. Tetanic @entity4 per unit cross-sectional area and the maximum rate of rise of @entity4 decreased during this period but, in the second week, the @entity4 recovered substantially and the maximum rate recovered completely. 3. Very small differences were seen between muscles denervated with @entity2 at day 4. 4. In the late stage of denervation (7-42 days) twitch and tetanic @entity4 fell more than cross-sectional area, but this may have been due to greater @entity3 of fibres compared with other muscle tissue. 5. Apart from this @entity4 fall, there were only small changes in the fast muscle in the late stage of denervation. These were a fall in twitch- @entity1 ratio and a prolongation of relaxation. 6. In more than half of the soleus muscles there was a late reversal of some of the denervation changes, and these muscles showed a greater degree of @entity3 . The less atrophied soleus muscles maintained a prolonged twitch and a low rate of development of @entity4 . 7. It is concluded that denervation affects the contractile properties of muscle as early and as abruptly as it does the membrane properties, and that most of the contractile changes are a direct consequence of changes in excitation-contraction coupling alone.

title: The effects of denervation on contractile properties or XXXX skeletal muscle.

answer: @entity0


abstract: WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:        Weight or @entity4 per se may not indicate health status or health benefit.        There is no gold standard for assessing which @entity0 would benefit most from weight-loss interventions.        The King's Criteria is one of several recently proposed @entity2 classification systems. WHAT THIS STUDY ADDS:        The King's Criteria can capture health problems related to @entity2 and health benefits after @entity4 .        The King's Criteria is a reproducible scoring system.        Using the King's Criteria may help shift the focus of @entity0 and clinicians from @entity4 to health gain. SUMMARY: Body mass index (BMI) alone does not reflect health status in individuals. The King's Obesity Staging Criteria is a clinical tool for the assessment of @entity0 with complex @entity2 . We assessed the performance of a modified version of the King's Criteria by scoring 144 @entity2 @entity0 before and 1 year after bariatric surgery. We also evaluated inter-observer variability by having 11 clinicians score the same 12 @entity0 . The King's Obesity Staging Criteria comprise nine health domains: Airways, Body mass index, @entity3 , @entity1 , Economic complications, Functional limitations, @entity5 , Health status (perceived), and body Image. For each domain, a @entity0 's health is assigned a score of 0 ('normal health'), 1 ('at risk'), 2 ('established disease') or 3 ('advanced disease'). The @entity0 's mean BMI decreased from 48        7 to 37        7   kg   m(-2) post surgery. Before surgery, 84% of @entity0 were either in stage 2 ('established disease') or stage 3 ('advanced disease') for one or more domains other than BMI. The modified King's Criteria showed significant health improvements after surgery, with a higher proportion of @entity0 scored in stage 0 ('normal health') within each health domain (P   <   0.001 for all). Observers assigned the same score in >75% of cases for all domains except Health status perceived (71%) and body Image (65%). In conclusion the King's Criteria captured morbidity in @entity2 @entity0 and health gains after @entity4 . Different clinicians mostly assigned similar scores. The King's Criteria is a clinical tool that may help shift the focus of @entity0 and clinicians towards improving health and not only losing weight. REGISTRATION NUMBER: NCT01112228 (http://www.clinicaltrials.gov).

title: Assessment of XXXX beyond body mass index to determine benefit of treatment.

answer: @entity2


abstract: UNASSIGNED: The study of hard-to-reach populations presents significant challenges. Typically, a sampling frame is not available, and population members are difficult to identify or recruit from broader sampling frames. This is especially true of populations at high risk for @entity2 / @entity3 . Respondent-driven sampling (RDS) is often used in such settings with the primary goal of estimating the prevalence of @entity1 . In such populations, the number of @entity0 at risk for @entity1 and the number of @entity0 infected are of fundamental importance. This article presents a case-study of the estimation of the size of the hard-to-reach population based on data collected through RDS. We study two populations of female sex workers and @entity0 -who-have-sex-with- @entity0 in El Salvador. The approach is Bayesian and we consider different forms of prior information, including using the UNAIDS population size guidelines for this region. We show that the method is able to quantify the amount of information on population size available in RDS samples. As separate validation, we compare our results to those estimated by extrapolating from a capture-recapture study of El Salvadorian cities. The results of our case-study are largely comparable to those of the capture-recapture study when they differ from the UNAIDS guidelines. Our method is widely applicable to data from RDS studies and we provide a software package to facilitate this.

title: Estimating the size of populations at high risk for XXXX using respondent-driven sampling data.

answer: @entity2


abstract: BACKGROUND: @entity3 is one of several factors related to medication compliance in patients taking antipsychotic medication but the magnitude of this problem is unknown. AIM: Compare the self-reported sexual functioning of clinically stable @entity0 with @entity1 taking antipsychotic medication to that of healthy controls using the Turkish version of the 5-item Arizona Sexual Experience Scale (ASEX). This scale, which has previously been validated in @entity2 , assesses 5 components of sexual function: sex drive, sexual arousal, vaginal lubrication/penile erection, ability to achieve orgasm, and satisfaction with orgasm. METHODS: The Scale for the Assessment of Positive Symptoms, the Scale for Assessment of Negative Symptoms, and ASEX were administered to 101 clinically stable outpatients with @entity1 (38 females and 63 males). The ASEX was also administered to 89 control subjects (41 females and 48 males) without a history of @entity4 . Respondents were classified as having @entity3 if ASEX total score (range 5-30) >18, if any ASEX item score (range 1-6) >=  5, or if 3 or more ASEX items >= 4. RESULTS: Male @entity0 with @entity1 have significantly more self-reported @entity3 than healthy controls (46% vs. 8%). The prevalence of @entity3 is higher in female @entity0 than in male @entity0 (68% vs. 46%), but it was also very high in healthy female controls (68%), so the @entity3 of female @entity0 cannot be attributed to their illness or to the medications they are taking. Within the @entity0 group, there was no significant relationship between the severity of positive or negative symptoms and the severity of @entity3 , and the severity of sexual function was not different between @entity0 taking first-generation or second-generation antipsychotic medications. CONCLUSIONS: The very different findings by gender in @entity2 highlights the importance of assessing location-specific and gender-specific sexual norms when trying to assess the role of @entity4 and medications on sexual functioning. Prospective studies are needed to distinguish the relative importance of cultural norms, the @entity1 , and the use of antipsychotic medication in the etiology and course of @entity3 among individuals with @entity1 .

title: @entity3 in outpatients with @entity1 in XXXX : a cross-sectional study.

answer: @entity2


abstract: BACKGROUND: @entity3 is one of several factors related to medication compliance in patients taking antipsychotic medication but the magnitude of this problem is unknown. AIM: Compare the self-reported sexual functioning of clinically stable @entity0 with @entity1 taking antipsychotic medication to that of healthy controls using the Turkish version of the 5-item Arizona Sexual Experience Scale (ASEX). This scale, which has previously been validated in @entity2 , assesses 5 components of sexual function: sex drive, sexual arousal, vaginal lubrication/penile erection, ability to achieve orgasm, and satisfaction with orgasm. METHODS: The Scale for the Assessment of Positive Symptoms, the Scale for Assessment of Negative Symptoms, and ASEX were administered to 101 clinically stable outpatients with @entity1 (38 females and 63 males). The ASEX was also administered to 89 control subjects (41 females and 48 males) without a history of @entity4 . Respondents were classified as having @entity3 if ASEX total score (range 5-30) >18, if any ASEX item score (range 1-6) >=  5, or if 3 or more ASEX items >= 4. RESULTS: Male @entity0 with @entity1 have significantly more self-reported @entity3 than healthy controls (46% vs. 8%). The prevalence of @entity3 is higher in female @entity0 than in male @entity0 (68% vs. 46%), but it was also very high in healthy female controls (68%), so the @entity3 of female @entity0 cannot be attributed to their illness or to the medications they are taking. Within the @entity0 group, there was no significant relationship between the severity of positive or negative symptoms and the severity of @entity3 , and the severity of sexual function was not different between @entity0 taking first-generation or second-generation antipsychotic medications. CONCLUSIONS: The very different findings by gender in @entity2 highlights the importance of assessing location-specific and gender-specific sexual norms when trying to assess the role of @entity4 and medications on sexual functioning. Prospective studies are needed to distinguish the relative importance of cultural norms, the @entity1 , and the use of antipsychotic medication in the etiology and course of @entity3 among individuals with @entity1 .

title: @entity3 in outpatients with XXXX in @entity2 : a cross-sectional study.

answer: @entity1


abstract: BACKGROUND: @entity3 is one of several factors related to medication compliance in patients taking antipsychotic medication but the magnitude of this problem is unknown. AIM: Compare the self-reported sexual functioning of clinically stable @entity0 with @entity1 taking antipsychotic medication to that of healthy controls using the Turkish version of the 5-item Arizona Sexual Experience Scale (ASEX). This scale, which has previously been validated in @entity2 , assesses 5 components of sexual function: sex drive, sexual arousal, vaginal lubrication/penile erection, ability to achieve orgasm, and satisfaction with orgasm. METHODS: The Scale for the Assessment of Positive Symptoms, the Scale for Assessment of Negative Symptoms, and ASEX were administered to 101 clinically stable outpatients with @entity1 (38 females and 63 males). The ASEX was also administered to 89 control subjects (41 females and 48 males) without a history of @entity4 . Respondents were classified as having @entity3 if ASEX total score (range 5-30) >18, if any ASEX item score (range 1-6) >=  5, or if 3 or more ASEX items >= 4. RESULTS: Male @entity0 with @entity1 have significantly more self-reported @entity3 than healthy controls (46% vs. 8%). The prevalence of @entity3 is higher in female @entity0 than in male @entity0 (68% vs. 46%), but it was also very high in healthy female controls (68%), so the @entity3 of female @entity0 cannot be attributed to their illness or to the medications they are taking. Within the @entity0 group, there was no significant relationship between the severity of positive or negative symptoms and the severity of @entity3 , and the severity of sexual function was not different between @entity0 taking first-generation or second-generation antipsychotic medications. CONCLUSIONS: The very different findings by gender in @entity2 highlights the importance of assessing location-specific and gender-specific sexual norms when trying to assess the role of @entity4 and medications on sexual functioning. Prospective studies are needed to distinguish the relative importance of cultural norms, the @entity1 , and the use of antipsychotic medication in the etiology and course of @entity3 among individuals with @entity1 .

title: XXXX in outpatients with @entity1 in @entity2 : a cross-sectional study.

answer: @entity3


abstract: OBJECTIVE: To determine factors associated with future falls and/or near falls in @entity0 with mild @entity3 . METHODS: The study included 141 @entity0 with @entity3 . Mean (SD) age and @entity3 -duration were 68 (9.7) and 4 years (3.9), respectively. Their median (q1-q3) UPDRS III score was 13 (8-18). Those >80 years of age, requiring support in standing or unable to understand instructions were excluded. Self-administered questionnaires targeted freezing of gait, turning hesitations, walking difficulties in daily life, fatigue, fear of falling, independence in activities of daily living, @entity2 , demographics, falls/near falls history, balance problems while dual tasking and @entity1 . Clinical assessments addressed functional balance performance, retropulsion, comfortable gait speed, motor symptoms and cognition. All falls and near falls were subsequently registered in a diary during a six-month period. Risk factors for prospective falls and/or near falls were determined using logistic regression. RESULTS: Sixty-three @entity0 (45%) experienced >= 1 fall and/or near fall. Three factors were independent predictors of falls and/or near falls: fear of falling (OR = 1.032, p<0.001) history of near falls (OR = 3.475, p = 0.009) and retropulsion (OR = 2.813, p = 0.035). The strongest contributing factor was fear of falling, followed by a history of near falls and retropulsion. CONCLUSIONS: Fear of falling seems to be an important issue to address already in mild @entity3 as well as asking about prior near falls.

title: Prediction of Falls and/or Near Falls in XXXX with Mild Parkinson's Disease.

answer: @entity0


abstract: An 11-year-old @entity0 was evaluated for mild periodic @entity1 exacerbated on separate occasions by @entity13 and @entity9 . He and his mother both had bidirectional ventricular tachydysrhythmia (BVT), @entity2 , @entity12 , and @entity14 . The mother, but not the @entity0 , had @entity15 . The two antiarrhythmic drugs worsened the @entity1 without benefiting the @entity4 . @entity5 loading produced skeletal @entity1 and transient conversion of the BVT to normal sinus rhythm. @entity7 aggravated the BVT without causing @entity1 . @entity11 had no effect. The @entity0 suffered a nonfatal @entity6 after several days of increased @entity8 intake. @entity10 controlled the @entity4 without inducing @entity1 . @entity3 should be considered as the diagnosis in @entity0 with BVT, a potentially fatal condition.

title: Potentially fatal XXXX and hyperkalemic periodic @entity3 .

answer: @entity4


abstract: An 11-year-old @entity0 was evaluated for mild periodic @entity1 exacerbated on separate occasions by @entity13 and @entity9 . He and his mother both had bidirectional ventricular tachydysrhythmia (BVT), @entity2 , @entity12 , and @entity14 . The mother, but not the @entity0 , had @entity15 . The two antiarrhythmic drugs worsened the @entity1 without benefiting the @entity4 . @entity5 loading produced skeletal @entity1 and transient conversion of the BVT to normal sinus rhythm. @entity7 aggravated the BVT without causing @entity1 . @entity11 had no effect. The @entity0 suffered a nonfatal @entity6 after several days of increased @entity8 intake. @entity10 controlled the @entity4 without inducing @entity1 . @entity3 should be considered as the diagnosis in @entity0 with BVT, a potentially fatal condition.

title: Potentially fatal @entity4 and hyperkalemic periodic XXXX .

answer: @entity3


abstract: BACKGROUND: The NF-kB pathway and @entity5 ( @entity5 ) are involved in @entity2 modulation; however, the precise mechanisms of their interactions in chronic @entity0 have yet to be established. METHODS: The present study examined the roles of spinal NF-kB and @entity5 in a @entity0 model after @entity6 ( @entity6 ) surgery. @entity6 -induced @entity2 facilitation was evaluated using the Plantar and von Frey tests. The changes in NF-kB and @entity5 expression were analyzed by immunohistochemistry and Western blot analyses. RESULTS: Spinal NF-kB and @entity5 expression increased after @entity6 surgery. Repeated intrathecal infusions of @entity7 ( @entity8 , a NF-kB inhibitor) decreased @entity5 expression, inhibited the activation of microglia and astrocytes, and attenuated @entity6 -induced @entity4 and @entity4 . Intrathecal injection of a @entity5 -neutralizing antibody attenuated @entity6 -induced @entity2 facilitation and also suppressed spinal glial cell activation after @entity6 surgery. However, the @entity5 -neutralizing antibody did not affect NF-kB expression. Furthermore, selective glial inhibitors, @entity3 and @entity9 , attenuated the @entity4 induced by intrathecal @entity5 . CONCLUSIONS: The inhibition of spinal @entity5 expression may provide a new method to prevent and treat @entity1 -induced @entity0 .

title: Spinal NF-kB and Chemokine Ligand 5 Expression during Spinal Glial Cell Activation in a XXXX Model.

answer: @entity0


abstract: BACKGROUND: The immediate postnatal period is the period of the fastest growth in the entire life span and a critical period for lung development. Therefore, it is interesting to examine the association between growth during this period and childhood @entity2 . METHODS: We examined the association of peak weight and height velocity to age 36 months with maternal report of current @entity1 at 36 months (n = 50,311), recurrent @entity3 ( @entity3 ) by 36 months (n = 47,905) and current @entity1 at 7 years (n = 24,827) in the Norwegian Mother and @entity0 Cohort Study. Peak weight and height velocity was calculated using the Reed1 model through multilevel mixed-effects linear regression. Multivariable log-binomial regression was used to calculate adjusted relative risks (adj.RR) and 95% confidence intervals (CI). We also conducted a sibling pair analysis using conditional logistic regression. RESULTS: Peak weight velocity was positively associated with current @entity1 at 36 months [adj.RR 1.22 (95%CI: 1.18, 1.26) per standard deviation (SD) increase], recurrent @entity3 by 36 months [adj.RR 1.14 (1.10, 1.19) per SD increase] and current @entity1 at 7 years [adj.RR 1.13 (95%CI: 1.07, 1.19) per SD increase]. Peak height velocity was not associated with any of the @entity2 . The positive association of peak weight velocity and @entity1 at 36 months remained in the sibling pair analysis. CONCLUSIONS: Higher peak weight velocity, achieved during the immediate postnatal period, increased the risk of @entity2 . This might be explained by an influence on neonatal lung development, shared genetic/epigenetic mechanisms and/or environmental factors.

title: Peak Weight and Height Velocity to Age 36 Months and Asthma Development: The Norwegian Mother and XXXX Cohort Study.

answer: @entity0


abstract: BACKGROUND: @entity2 is a serious global health problem. There is substantial evidence that physicians' attitudes towards and beliefs about @entity2 can influence their subsequent management of the condition. OBJECTIVES: (1) to evaluate the attitudes and beliefs towards @entity2 among primary care physicians in Asia; (2) to study the cultural differences and other factors that are associated with these attitudes and beliefs. METHOD: A cross sectional online survey was sent to primary care physicians who are members of the Hong Kong College of Family Physician (HKCFP). The @entity1 Attitudes and Beliefs Scale for Physiotherapist (PABS-PT) was used as the questionnaire to determine the biomedical and biopsychosocial orientation of the @entity0 . RESULTS: The mean Biomedical (BM) score was 34.8+/-6.1; the mean biopsychosocial (BPS) score was 35.6 (+/- 4.8). Both scores were higher than those of European doctors. Family medicine specialists had a lower biomedical score than General practitioners. Physicians working in the public sector tended to have low BM and low BPS scores; whereas physicians working in private practice tended to have high BM and high BPS scores. CONCLUSION: The lack of concordance in the @entity1 explanatory models used by private and public sector may have a detrimental effect on @entity0 who are under the care of both parties. The uncertain treatment orientation may have a negative influence on @entity0 ' attitudes and beliefs, thus contributing to the @entity3 and, perhaps, even ailing mental state of a @entity0 with chronic @entity4 .

title: Primary Care Physicians' Attitudes and Beliefs towards XXXX : An Asian Study.

answer: @entity2


abstract: INTRODUCTION: @entity4 ( @entity4 ), @entity3 ( @entity3 ), and @entity2 ( @entity2 ) manifest as various, multiple symptoms from malfunctioning and/or damaged gastrointestinal tract, which plague the @entity0 . These symptoms result from the dysfunctional expression products of the specific mutations of the genes, which either manifest upon birth ( @entity4 ) or later in life in immuno-genetically susceptible individuals as @entity1 ( @entity1 ). They all may potentially lead to @entity5 of the @entity0 . Since only correcting the mutated genes, may cure these diseases permanently, the works on the future safe gene therapies continue vigorously. However, provision of the necessary nutrients to the suffering @entity0 is the requirement for an effective, supportive care at present. In this realm, we have developed a model of the diseased gastrointestinal tract aimed to guide designing and testing various nutritional therapies. MATERIALS AND METHODS: It is well known that @entity1 induce crypts within the @entity0 ' gastrointestinal tract. Therefore, we have bioengineered, a novel, three-dimensional model of the gastrointestinal tract to evaluate the rheology of different types of nutrients. The model was assembled out of the bio-inert polymer tube with openings leading to vials of different shapes and sizes, as the simulation of the gastrointestinal tract altered by the diseases to contain multiple crypts. RESULTS AND CONCLUSIONS: The newly developed three-dimensional model effectively simulates the structure and functions of the gastrointestinal tract of the @entity0 with mild and severe @entity3 , @entity2 , and @entity4 . This model should allow us to design and test different nutritional supplements, with properties complementing the pathologically altered by the diseases functionalities of the @entity0 ' gastrointestinal tracts. Therefore, it should help us to design the effective supportive therapies; thus to prevent the @entity0 ' @entity5 .

title: A 3D Polymer Model for Future Nutrition Design Novel Nutrition Approach for @entity4 , XXXX and @entity2 .

answer: @entity3


abstract: INTRODUCTION: @entity4 ( @entity4 ), @entity3 ( @entity3 ), and @entity2 ( @entity2 ) manifest as various, multiple symptoms from malfunctioning and/or damaged gastrointestinal tract, which plague the @entity0 . These symptoms result from the dysfunctional expression products of the specific mutations of the genes, which either manifest upon birth ( @entity4 ) or later in life in immuno-genetically susceptible individuals as @entity1 ( @entity1 ). They all may potentially lead to @entity5 of the @entity0 . Since only correcting the mutated genes, may cure these diseases permanently, the works on the future safe gene therapies continue vigorously. However, provision of the necessary nutrients to the suffering @entity0 is the requirement for an effective, supportive care at present. In this realm, we have developed a model of the diseased gastrointestinal tract aimed to guide designing and testing various nutritional therapies. MATERIALS AND METHODS: It is well known that @entity1 induce crypts within the @entity0 ' gastrointestinal tract. Therefore, we have bioengineered, a novel, three-dimensional model of the gastrointestinal tract to evaluate the rheology of different types of nutrients. The model was assembled out of the bio-inert polymer tube with openings leading to vials of different shapes and sizes, as the simulation of the gastrointestinal tract altered by the diseases to contain multiple crypts. RESULTS AND CONCLUSIONS: The newly developed three-dimensional model effectively simulates the structure and functions of the gastrointestinal tract of the @entity0 with mild and severe @entity3 , @entity2 , and @entity4 . This model should allow us to design and test different nutritional supplements, with properties complementing the pathologically altered by the diseases functionalities of the @entity0 ' gastrointestinal tracts. Therefore, it should help us to design the effective supportive therapies; thus to prevent the @entity0 ' @entity5 .

title: A 3D Polymer Model for Future Nutrition Design Novel Nutrition Approach for @entity4 , @entity3 and XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity4 ( @entity4 ), @entity3 ( @entity3 ), and @entity2 ( @entity2 ) manifest as various, multiple symptoms from malfunctioning and/or damaged gastrointestinal tract, which plague the @entity0 . These symptoms result from the dysfunctional expression products of the specific mutations of the genes, which either manifest upon birth ( @entity4 ) or later in life in immuno-genetically susceptible individuals as @entity1 ( @entity1 ). They all may potentially lead to @entity5 of the @entity0 . Since only correcting the mutated genes, may cure these diseases permanently, the works on the future safe gene therapies continue vigorously. However, provision of the necessary nutrients to the suffering @entity0 is the requirement for an effective, supportive care at present. In this realm, we have developed a model of the diseased gastrointestinal tract aimed to guide designing and testing various nutritional therapies. MATERIALS AND METHODS: It is well known that @entity1 induce crypts within the @entity0 ' gastrointestinal tract. Therefore, we have bioengineered, a novel, three-dimensional model of the gastrointestinal tract to evaluate the rheology of different types of nutrients. The model was assembled out of the bio-inert polymer tube with openings leading to vials of different shapes and sizes, as the simulation of the gastrointestinal tract altered by the diseases to contain multiple crypts. RESULTS AND CONCLUSIONS: The newly developed three-dimensional model effectively simulates the structure and functions of the gastrointestinal tract of the @entity0 with mild and severe @entity3 , @entity2 , and @entity4 . This model should allow us to design and test different nutritional supplements, with properties complementing the pathologically altered by the diseases functionalities of the @entity0 ' gastrointestinal tracts. Therefore, it should help us to design the effective supportive therapies; thus to prevent the @entity0 ' @entity5 .

title: A 3D Polymer Model for Future Nutrition Design Novel Nutrition Approach for XXXX , @entity3 and @entity2 .

answer: @entity4


abstract: @entity1 is associated with a variety of inflammatory diseases. Treg populations are defined by expression of the oligomeric transcription factor @entity6 and inability to produce @entity5 , a cytokine required for T cell maintenance and survival. @entity6 activity is regulated post-translationally by histone/protein acetyltransferases and histone/protein deacetylases (HDACs). Here, we determined that @entity7 mediates both the development and function of the two main Treg subsets, thymus-derived Tregs and induced Tregs (iTregs). We determined that @entity7 and @entity6 physically interact and that @entity7 expression markedly reduces @entity5 promoter activity. In @entity0 models, conditional deletion of @entity7 during thymic Treg development restored Treg production of @entity5 and blocked the suppressive function of Tregs. @entity7 -deficient @entity0 died from autoimmunity by 4-6 weeks of age; however, injection of WT @entity6 + Tregs prolonged survival. Adoptive transfer of @entity7 -deficient Tregs, unlike WT Tregs, did not control T cell proliferation in naive @entity0 and did not prevent allograft rejection or @entity4 . @entity7 also regulated the development of iTregs, as @entity7 -deficient conventional T cells were not converted into iTregs under polarizing conditions and produced large amounts of @entity5 , @entity3 , and @entity2 . We conclude that @entity7 is essential for the normal development and suppressive functions of thymic and peripheral @entity6 + Tregs.

title: XXXX + regulatory T cell development and function require histone/protein deacetylase 3.

answer: @entity6


abstract: BACKGROUND: @entity5 and @entity4 are commonly used antidepressants for treatment of @entity3 in older @entity0 . Both drugs are metabolized by the polymorphic @entity6 ( @entity6 ) enzyme and guidelines for dose adaptations based on the @entity6 genotype have been developed. The @entity6 Screening Among Elderly (CYSCE) trial is designed to address the potential health and economic value of genotyping for @entity6 in optimizing dose-finding of @entity5 and @entity4 . METHODS/DESIGN: In a pragmatic randomized controlled trial, @entity0 diagnosed with a major @entity3 according to the DSM-IV and aged 60  years or older will be recruited from @entity2 centers across the Netherlands. After @entity6 genotyping determined in peripheral blood obtained by finger-prick, @entity0 will be grouped into poor, intermediate, extensive, or ultrarapid metabolizers. @entity0 with deviant genotype (that is poor, intermediate or ultrarapid genotype) will be randomly allocated to an intervention group in which the genotype and dosing advice is communicated to the treating physician, or to a control group in which @entity0 receive care as usual. Additionally, an external reference group of @entity0 with the extensive metabolizer genotype is included. Primary outcome in all groups is time needed to obtain an adequate blood level of the antidepressant drug. Secondary outcomes include @entity1 measured by a shortened Antidepressant Side-Effects Checklist (ASEC), and cost-effectiveness of the screening. DISCUSSION: Results of this trial will guide policy-making with regard to pharmacogenetic screening prior to treatment with @entity5 or @entity4 among older @entity0 with @entity3 . TRIAL REGISTRATION: ClinicalTrials.gov: NCT01778907 ; registration date: 22 January 2013.

title: Effects and cost-effectiveness of pharmacogenetic screening for @entity6 among older adults starting therapy with XXXX or @entity4 : study protocol for a pragmatic randomized controlled trial (CYSCEtrial).

answer: @entity5


abstract: BACKGROUND: @entity5 and @entity4 are commonly used antidepressants for treatment of @entity3 in older @entity0 . Both drugs are metabolized by the polymorphic @entity6 ( @entity6 ) enzyme and guidelines for dose adaptations based on the @entity6 genotype have been developed. The @entity6 Screening Among Elderly (CYSCE) trial is designed to address the potential health and economic value of genotyping for @entity6 in optimizing dose-finding of @entity5 and @entity4 . METHODS/DESIGN: In a pragmatic randomized controlled trial, @entity0 diagnosed with a major @entity3 according to the DSM-IV and aged 60  years or older will be recruited from @entity2 centers across the Netherlands. After @entity6 genotyping determined in peripheral blood obtained by finger-prick, @entity0 will be grouped into poor, intermediate, extensive, or ultrarapid metabolizers. @entity0 with deviant genotype (that is poor, intermediate or ultrarapid genotype) will be randomly allocated to an intervention group in which the genotype and dosing advice is communicated to the treating physician, or to a control group in which @entity0 receive care as usual. Additionally, an external reference group of @entity0 with the extensive metabolizer genotype is included. Primary outcome in all groups is time needed to obtain an adequate blood level of the antidepressant drug. Secondary outcomes include @entity1 measured by a shortened Antidepressant Side-Effects Checklist (ASEC), and cost-effectiveness of the screening. DISCUSSION: Results of this trial will guide policy-making with regard to pharmacogenetic screening prior to treatment with @entity5 or @entity4 among older @entity0 with @entity3 . TRIAL REGISTRATION: ClinicalTrials.gov: NCT01778907 ; registration date: 22 January 2013.

title: Effects and cost-effectiveness of pharmacogenetic screening for @entity6 among older adults starting therapy with @entity5 or XXXX : study protocol for a pragmatic randomized controlled trial (CYSCEtrial).

answer: @entity4


abstract: BACKGROUND: @entity5 and @entity4 are commonly used antidepressants for treatment of @entity3 in older @entity0 . Both drugs are metabolized by the polymorphic @entity6 ( @entity6 ) enzyme and guidelines for dose adaptations based on the @entity6 genotype have been developed. The @entity6 Screening Among Elderly (CYSCE) trial is designed to address the potential health and economic value of genotyping for @entity6 in optimizing dose-finding of @entity5 and @entity4 . METHODS/DESIGN: In a pragmatic randomized controlled trial, @entity0 diagnosed with a major @entity3 according to the DSM-IV and aged 60  years or older will be recruited from @entity2 centers across the Netherlands. After @entity6 genotyping determined in peripheral blood obtained by finger-prick, @entity0 will be grouped into poor, intermediate, extensive, or ultrarapid metabolizers. @entity0 with deviant genotype (that is poor, intermediate or ultrarapid genotype) will be randomly allocated to an intervention group in which the genotype and dosing advice is communicated to the treating physician, or to a control group in which @entity0 receive care as usual. Additionally, an external reference group of @entity0 with the extensive metabolizer genotype is included. Primary outcome in all groups is time needed to obtain an adequate blood level of the antidepressant drug. Secondary outcomes include @entity1 measured by a shortened Antidepressant Side-Effects Checklist (ASEC), and cost-effectiveness of the screening. DISCUSSION: Results of this trial will guide policy-making with regard to pharmacogenetic screening prior to treatment with @entity5 or @entity4 among older @entity0 with @entity3 . TRIAL REGISTRATION: ClinicalTrials.gov: NCT01778907 ; registration date: 22 January 2013.

title: Effects and cost-effectiveness of pharmacogenetic screening for XXXX among older adults starting therapy with @entity5 or @entity4 : study protocol for a pragmatic randomized controlled trial (CYSCEtrial).

answer: @entity6


abstract: PURPOSE: The aim of this study is to investigate factors associated with residual symptoms after hyperbaric @entity1 therapy (HBOT) in type I @entity2 ( @entity2 ). BASIC PROCEDURES: An HBOT registry, which includes @entity0 with type I @entity2 , was analyzed retrospectively. We divided enrolled @entity0 into two groups; complete resolution group and residual symptom (RS) group after a single HBOT session. We investigated factors associated with residual symptoms at discharge with univariable and multivariable analyses. Restrictive cubic spline curve and a test for trend analysis were used to show the trend of therapeutic response after HBOT based on time from symptom onset to HBOT. MAIN FINDINGS: In a total of 195 @entity0 , 131 (67.2%) @entity0 were included in the RS group after single HBOT. Prolonged time from symptom onset to recompression was independently associated with residual symptoms (P = .004). When @entity0 who underwent recompression within 24 hours from symptom were included in the reference group, the adjusted odds ratios (AOR) (95% confidence interval) of residual symptoms after HBOT were the following: 24 to 96 hours, 2.24 (0.75-6.65); 96 to 240 hours, 3.31 (1.08-10.13); more than 240 hours, 22.83 (2.45-231.43). In terms of sort of diving, commercial and recreational divers had higher probability of residual symptoms than military divers (AOR, 4.78 and 33.36, respectively). PRINCIPAL CONCLUSIONS: Early HBOT is associated with rapid symptom elimination after treatment in type I @entity2 . Military divers showed a more immediate response after recompression in comparison with commercial and recreational divers.

title: Factors associated with residual symptoms after recompression in type I XXXX .

answer: @entity2


abstract: Flow cytometry (FCM) was used to study the DNA distribution of 99 @entity1 biopsy specimens and 41 bladder irrigation samples from @entity0 with transitional cell @entity2 . For @entity1 biopsy and cystectomy specimens, the frequency of aneuploidy increased with advancing @entity1 stage and grade. All T0 @entity1 were diploid. Twenty-seven percent of T1, 71.4% of T2, and 75% of T3 and T4 @entity1 were @entity4 . All Grade I @entity1 were diploid. Thirty percent of Grade II and 76.9% of @entity1 were @entity4 . The frequency of @entity1 in the early stages (Ta, T1) is similar to the incidence of subsequent progression by these @entity1 described in the literature. For irrigation fluids, the relationship between grade and stage and the frequency of aneuploidy was similar to the relationship seen with @entity1 specimens. All four @entity0 with @entity3 in situ had @entity4 cells in their irrigations. The comparison of FCM data of bladder biopsy and bladder irrigation from the same cystoscopic evaluation suggests adequate representation of @entity1 cells in the irrigation fluids for almost all cases. The authors conclude that DNA ploidy analysis by FCM appears useful in a clinically important group of @entity0 with @entity4 superficial @entity1 of moderate or high grade. Bladder irrigation analysis appears useful in the follow-up of @entity0 with a history of @entity3 in situ and those with @entity1 .

title: Flow cytometric analysis of DNA content in @entity0 XXXX and irrigation fluids.

answer: @entity2


abstract: Flow cytometry (FCM) was used to study the DNA distribution of 99 @entity1 biopsy specimens and 41 bladder irrigation samples from @entity0 with transitional cell @entity2 . For @entity1 biopsy and cystectomy specimens, the frequency of aneuploidy increased with advancing @entity1 stage and grade. All T0 @entity1 were diploid. Twenty-seven percent of T1, 71.4% of T2, and 75% of T3 and T4 @entity1 were @entity4 . All Grade I @entity1 were diploid. Thirty percent of Grade II and 76.9% of @entity1 were @entity4 . The frequency of @entity1 in the early stages (Ta, T1) is similar to the incidence of subsequent progression by these @entity1 described in the literature. For irrigation fluids, the relationship between grade and stage and the frequency of aneuploidy was similar to the relationship seen with @entity1 specimens. All four @entity0 with @entity3 in situ had @entity4 cells in their irrigations. The comparison of FCM data of bladder biopsy and bladder irrigation from the same cystoscopic evaluation suggests adequate representation of @entity1 cells in the irrigation fluids for almost all cases. The authors conclude that DNA ploidy analysis by FCM appears useful in a clinically important group of @entity0 with @entity4 superficial @entity1 of moderate or high grade. Bladder irrigation analysis appears useful in the follow-up of @entity0 with a history of @entity3 in situ and those with @entity1 .

title: Flow cytometric analysis of DNA content in XXXX @entity2 and irrigation fluids.

answer: @entity0


abstract: Six @entity0 with @entity2 diagnosed during late pregnancy or shortly thereafter are reported. Three @entity0 had @entity2 and three, intermediate-grade histologic features. Five of the six @entity0 were in Stage 4 and one was Stage 1. Only three had the diagnosis of @entity2 during pregnancy, and in these three cases the disease appeared to progress rapidly after delivery. The other three @entity0 probably had @entity1 during pregnancy; @entity1 was widespread at the time of their diagnosis, but the diagnosis was only established on biopsy specimens after delivery in all three instances. Five @entity0 had full-term natural deliveries with normal @entity0 . A single @entity0 with @entity3 had a @entity4 with a cesarean section in the 29th week because of @entity5 probably due to @entity1 of the uterine wall. In this case both mother and @entity0 died within 48 hours of delivery. The other five @entity0 were treated soon after delivery. Published literature dealing with this topic is scanty and inconclusive; accordingly this report attempts to discuss management of @entity1 in pregnancy, based on the authors' limited experience with these six @entity0 .

title: XXXX associated with pregnancy. A report of six cases, with a review of the literature.

answer: @entity2


abstract: A series of @entity1 @entity0 subpopulation lines were compared for growth properties and sensitivity to chemotherapeutic drugs when grown as boluses in a collagen gel matrix versus in monolayer culture. Although the cell lines exhibited characteristic rates of bolus expansion in collagen, this growth was not paralleled by an exponential increase in cell number with time. Cell boluses contained a higher proportion of cells in G0-G1 phases of the cell cycle than did the same cell lines in monolayer cultures. Histological examination revealed areas of @entity2 in boluses. Thus cells growing in collagen cultures resembled cells growing as solid @entity0 and cells from other three-dimensional culture systems. The growth of cell boluses in collagen gel cultures was reduced nonexponentially by melphalan, @entity4 , and @entity3 in contrast to the exponential decrease in growth measured in cloning assays. The lowest concentration to which cells first responded to drug was in general similar for collagen gel assays and for cloning assays. The rank order of sensitivity of different cell lines in the two assays was identical for @entity4 (four cell lines), similar for @entity5 (four of five lines), but quite different for @entity3 . In contrast to cloning assays cell boluses continued to grow, albeit at a reduced rate, in the presence of high drug concentrations. This was not due to either diminished drug availability in collagen gel or drug penetration into the bolus.

title: Factors affecting growth and drug sensitivity of @entity1 XXXX lines in collagen gel cultures.

answer: @entity0


abstract: A series of @entity1 @entity0 subpopulation lines were compared for growth properties and sensitivity to chemotherapeutic drugs when grown as boluses in a collagen gel matrix versus in monolayer culture. Although the cell lines exhibited characteristic rates of bolus expansion in collagen, this growth was not paralleled by an exponential increase in cell number with time. Cell boluses contained a higher proportion of cells in G0-G1 phases of the cell cycle than did the same cell lines in monolayer cultures. Histological examination revealed areas of @entity2 in boluses. Thus cells growing in collagen cultures resembled cells growing as solid @entity0 and cells from other three-dimensional culture systems. The growth of cell boluses in collagen gel cultures was reduced nonexponentially by melphalan, @entity4 , and @entity3 in contrast to the exponential decrease in growth measured in cloning assays. The lowest concentration to which cells first responded to drug was in general similar for collagen gel assays and for cloning assays. The rank order of sensitivity of different cell lines in the two assays was identical for @entity4 (four cell lines), similar for @entity5 (four of five lines), but quite different for @entity3 . In contrast to cloning assays cell boluses continued to grow, albeit at a reduced rate, in the presence of high drug concentrations. This was not due to either diminished drug availability in collagen gel or drug penetration into the bolus.

title: Factors affecting growth and drug sensitivity of XXXX @entity0 lines in collagen gel cultures.

answer: @entity1


abstract: PURPOSE: The  Korean Radiation Oncology Group (KROG) 08-06 study protocol allowed @entity4 ( @entity4 ) technique to include or exclude @entity0 @entity1 from receiving @entity4 to the internal mammary lymph node (IMN). The purpose of this study was to assess dosimetric differences between the 2 groups and potential influence on clinical outcome by a dummy run procedure. METHODS AND MATERIALS: All participating institutions were asked to produce @entity4 plans without irradiation ( @entity2 ) and with irradiation to the IMN ( @entity3 ) for 1 breast-conservation treatment case (breast-conserving surgery [BCS]) and 1 mastectomy case (modified radical mastectomy [MRM]) whose computed tomography images were provided. We assessed interinstitutional variations in IMN delineation and evaluated the dose-volume histograms of the IMN and normal organs. A reference IMN was delineated by an expert panel group based on the study guidelines. Also, we analyzed the potential influence of actual dose variation observed in this study on @entity1 survival. RESULTS: Although physicians intended to exclude the IMN within the @entity4 field, the data showed almost 59.0% of the prescribed dose was delivered to the IMN in @entity2 . However, the mean doses covering the IMN in @entity2 and @entity3 were significantly different for both cases (P<.001). Due to the probability of @entity5 in @entity2 , the estimated gain in 7-year disease-free survival rate would be reduced from 10% to 7.9% for BCS cases and 7.1% for MRM cases. The radiation doses to the ipsilateral lung, heart, and coronary artery were lower in @entity2 than in @entity3 . CONCLUSIONS: Although this dummy run study indicated that a substantial dose was delivered to the IMN, even in the nonirradiation group, the dose differences between the 2 groups were statistically significant. However, this dosimetric profile should be studied further with actual @entity1 samples and be taken into consideration when analyzing clinical outcomes according to IMN irradiation.

title: Dummy run of quality assurance program in a phase 3 randomized trial investigating the role of internal mammary lymph node irradiation in XXXX @entity1 : korean radiation oncology group 08-06 study.

answer: @entity0


abstract: PURPOSE: The  Korean Radiation Oncology Group (KROG) 08-06 study protocol allowed @entity4 ( @entity4 ) technique to include or exclude @entity0 @entity1 from receiving @entity4 to the internal mammary lymph node (IMN). The purpose of this study was to assess dosimetric differences between the 2 groups and potential influence on clinical outcome by a dummy run procedure. METHODS AND MATERIALS: All participating institutions were asked to produce @entity4 plans without irradiation ( @entity2 ) and with irradiation to the IMN ( @entity3 ) for 1 breast-conservation treatment case (breast-conserving surgery [BCS]) and 1 mastectomy case (modified radical mastectomy [MRM]) whose computed tomography images were provided. We assessed interinstitutional variations in IMN delineation and evaluated the dose-volume histograms of the IMN and normal organs. A reference IMN was delineated by an expert panel group based on the study guidelines. Also, we analyzed the potential influence of actual dose variation observed in this study on @entity1 survival. RESULTS: Although physicians intended to exclude the IMN within the @entity4 field, the data showed almost 59.0% of the prescribed dose was delivered to the IMN in @entity2 . However, the mean doses covering the IMN in @entity2 and @entity3 were significantly different for both cases (P<.001). Due to the probability of @entity5 in @entity2 , the estimated gain in 7-year disease-free survival rate would be reduced from 10% to 7.9% for BCS cases and 7.1% for MRM cases. The radiation doses to the ipsilateral lung, heart, and coronary artery were lower in @entity2 than in @entity3 . CONCLUSIONS: Although this dummy run study indicated that a substantial dose was delivered to the IMN, even in the nonirradiation group, the dose differences between the 2 groups were statistically significant. However, this dosimetric profile should be studied further with actual @entity1 samples and be taken into consideration when analyzing clinical outcomes according to IMN irradiation.

title: Dummy run of quality assurance program in a phase 3 randomized trial investigating the role of internal mammary lymph node irradiation in @entity0 XXXX : korean radiation oncology group 08-06 study.

answer: @entity1


abstract: PURPOSE: To compare anterior segment parameters in Chinese and Japanese subjects with angle closure using anterior segment optical coherence tomography (ASOCT). METHODS: One hundred and forty-two Japanese and one hundred and ninety-two Chinese subjects with primary angle closure (PAC) or primary @entity2 (PACG) were recruited. All @entity0 underwent A-scan biometry and ASOCT imaging (Visante, Carl Zeiss Meditec, Dublin, CA, USA). Customized software was used to measure ASOCT parameters in horizontal ASOCT scans. The parameters were compared, and multivariate analysis was performed to determine predictors of angle opening distance at 750   m from the scleral spur (AOD750). RESULTS: Ethnic difference evaluated by multiple linear regression adjusted for age, gender, spherical equivalent, @entity3 , and axial length showed that Japanese angle-closure subjects had significantly shallower anterior chamber depth ( @entity4 ;b   =   -0.3, p   <   0.001), smaller anterior chamber area (ACA; b   =   -0.21, p   =   0.02) and volume (ACV; b   =   -0.19, p   =   0.01), greater lens vault (LV, b   =   0.3, p   <   0.001), lens thickness (LT; b   =   0.48, p   <   0.001), greater iris area (IArea; b   =   0.19, p   =   0.01), and more curved iris (ICurv; b   =   0.16, p   =   0.04). The significant determinants of AOD750 were @entity1 ( @entity1 ; b   =   -0.21, p   =   0.04), ICurv (b   =   -0.17, p   =   0.04), @entity3 ( @entity3 ; b   =   -0.34, p   =   0.001) and ACV (b   =   0.32, p   <   0.001) in Japanese; and @entity1 (b   =   -0.25, p   =   0.001), ACV (b   =   0.37, p   <   0.001), @entity3 (b   =   -0.26, p   =   0.001), and LV (b   =   -0.18, p   =   0.03) in Chinese. CONCLUSIONS: Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses. ACV, @entity1 , and @entity3 are important factors for angle width in both races. These results suggest possible ethnic differences in angle-closure mechanism(s).

title: XXXX in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects.

answer: @entity2


abstract: UNASSIGNED: @entity5 , a ubiquitous and virulent bacterial pathogen, affects a variety of fishes, including @entity7 . Existing treatment strategies comprise antibiotic therapies and attenuated bacterial strain-based vaccines. No functional subunit vaccine has been available until now. Given their key role in determining pathogenicity, outer membrane proteins have been successfully explored as potential vaccine candidates. We have devised a direct strategy for eliminating non-specific responses by selectively aiming the immune response against specific immunodominant epitopes of the outer membrane protein F (OmpF) of A. hydrophila (AhOmpF). Five putative epitopes of AhOmpF predicted in silico were genetically conjugated with heat labile enterotoxin chain B of @entity2 (LTB). Recombinant fusion proteins expressed in @entity2 were purified from solubilized inclusion bodies and refolded. The fusion protein retained GM1 @entity6 receptor binding activity of LTB, indicating proper folding. Four of the five fusion proteins were found to be highly immunogenic. Of the four proteins, antisera against the fusion protein (anti-rEpiF1) harboring 66-80 @entity3 residues of the OmpF gave maximum cross-reactivity with the targeted rOmpF in enzyme-linked immunosorbent assay (ELISA) and was able to recognize both fusion partners-rOmpF and rLTB-in Western blot. Antibody isotyping of the antisera and cytokine array analysis of the culture supernatants of splenocytes from sensitized @entity0 manifested a mixed @entity4 / @entity1 immune response with a bias toward @entity1 . Anti-rEpiF1 antibodies were able to bind to the cell membrane of live A. hydrophila cells and agglutinate them. Our results thus suggest that the OmpF epitope (66-80) in fusion with a carrier protein is a promising vaccine candidate against A. hydrophila.

title: Identification and immunogenic potential of B cell epitopes of outer membrane protein OmpF of XXXX in translational fusion with a carrier protein.

answer: @entity5


abstract: The effect of @entity1 ( @entity2 ) on the composition of tissue gain of Hereford steers was studied in a complete slaughter balance trial. Eight steers were slaughtered initially (IS) and, after 177 days on feed, eight control steers (C) and seven steers that had been fed 20 mg @entity2 daily ( @entity2 ) were slaughtered. Initial full body weight averaged 224.8 kg, and final full body weight averaged 403.0 kg for the C steers and 433.6 kg for the @entity2 steers. Final empty body weight averaged 346.6 kg for the C steers and 368.0 kg for the @entity2 steers. @entity2 improved live @entity0 by 17% and conversion of feed dry matter to live weight by 12%. Recovery of wet weight during slaughter averaged 99.6%. @entity2 steers had larger rib cut weights and greater proportions of separable lean and bone plus connective tissue in the rib cuts than C steers, an ribeye area tended to be larger in @entity2 steers. @entity2 caused a small shift in relative body composition toward more protein, moisture and ash. Tissue gain in @entity2 steers consisted of 28.3% more protein, 26.0% more moisture, 73.2% more ash, 1.5% less fat and 109.1% more residual (dry matter not accounted for by N x 6.25, ether extract and ash) than did tissue gain in C steers. Energy gain per unit of energy intake over the feeding period was not affected by @entity2 treatment, but @entity2 improved protein gain per unit of protein intake and per unit of energy intake by approximately 20% within the total empty body and by about 25% within the carcass fraction. Results confirm indirect estimates in the literature indicating that @entity2 increases skeletal growth and lean tissue deposition in feedlot steers.

title: Effect of XXXX on tissue gain and carcass merit of feedlot beef steers.

answer: @entity1


abstract: We performed experiments on anesthetized, open-chest @entity0 to determine whether the @entity1 ( @entity3 and systemic @entity2 ) evoked by stimulating pulmonary C-fibers also involves reflex changes in coronary vascular resistance. We perfused the circumflex coronary artery at constant pressure (usually 100 mm Hg) and recorded mean circumflex blood flow. Stimulation of pulmonary C-fibers by right atrial injection of @entity4 (10 micrograms/kg) decreased arterial blood pressure and heart rate and increased circumflex blood flow by 32-109% (P less than 0.001). Circumflex blood flow also increased, by 26-100% (P less than 0.001), when heart rate was kept constant by pacing. Coronary vasodilation was not secondary to the reflex decrease in arterial blood pressure. Injecting @entity4 (10 micrograms/kg) into the left atrium did not increase circumflex blood flow. Reflex coronary vasodilation could still be evoked when myelinated nerve fibers were blocked selectively by cooling the cervical vagus nerves to 7-8 degrees C but was abolished by cooling to 0 degrees C, by cutting the pulmonary vagal branches, or by giving @entity5 . Reducing coronary perfusion pressure shifted the stimulus (dose of @entity4 )-response (increase in coronary blood flow) curve to the right, but, even at low perfusion pressures, significant reflex vasodilation still occurred. Regional (transmural) distribution of myocardial blood flow was measured by the microsphere technique at various perfusion pressures. The endocardial:epicardial blood flow ratio decreased significantly as perfusion pressure was reduced, but was not altered by right atrial injection of @entity4 at any perfusion pressure. Our results indicate that stimulation of pulmonary C-fibers triggers reflex cholinergic vasodilation in all layers of the myocardium.

title: Vagal chemoreflex coronary vasodilation evoked by stimulating pulmonary C-fibers in XXXX .

answer: @entity0


abstract: BACKGROUND: The superior thyroid artery (STA) is the most commonly used recipient vessel in free tissue transfer for head and neck reconstruction. Size discrepancy between recipient and donor vessels might affect the patency rate. The objective of this study was to compare the outcomes of the "open-Y" technique in end-to-end anastomoses between the STA and donor arteries to those of conventional anastomoses to the STA. @entity0 AND METHODS: A total of 337 @entity0 with free tissue transfer for head and neck reconstruction with the STA as the recipient artery were recruited between September 2011 and August 2013. The "open-Y" technique of @entity3 was used in 72 cases, whereas the conventional technique was applied in 256 cases. The arterial anastomotic site-related complications and size discrepancy rates of both groups were evaluated and compared. RESULTS: The flap success rate was 98.6% (71/72) in the "open-Y" group, which was similar to the conventional group [97.4% (245/252); P   =   0.999]. Size discrepancy rate was higher in the "open-Y" group [48/72(66.7%)] compared to that in the conventional group [31/265(11.7%), P   <   0.001]. There was no significant difference regarding arterial anastomotic site-related complications between the "open-Y" and conventional groups (1.4% vs.4.2%; P   =   0.473). Others complications, including re-exploration, @entity2 , @entity6 , @entity5 , @entity4 , partial flap @entity1 and @entity1 , had similar presentations. CONCLUSION: The utility of the "open-Y" technique, applied to STA as a recipient vessel, appeared to be a reasonable option for head and neck reconstruction. This technique seems to be promising for cases with vessels size discrepancy.    2015 Wiley Periodicals, Inc. Microsurgery, 2015.

title: Utility of "open-Y" XXXX technique in the use of superior thyroid artery as recipient vessel for head and neck reconstruction with free flap.

answer: @entity3


abstract: OBJECTIVE: This study was conducted to determine if type 1 @entity1 is associated with an increased risk of @entity3 across the life span. RESEARCH DESIGN AND METHODS: This population-based cohort study used data from @entity4 ( @entity4 ) in the U.K. (data from 1994 to 2012), in which 30,394 @entity0 aged 0-89 years with type 1 @entity1 were compared with 303,872 randomly selected age-, sex-, and practice-matched @entity0 without @entity1 . Cox regression analysis was used to determine hazard ratios (HRs) for incident @entity3 in @entity0 with type 1 @entity1 . RESULTS: A total of 334,266 @entity0 , median age 34 years, were monitored for 1.9 million @entity0 -years. HR were lowest in males and females age <20 years, with HR 1.14 (95% CI 1.01-1.29) and 1.35 (95% CI 1.12-1.63), respectively. Risk was highest in @entity0 60-69 years (HR 2.18 [95% CI 1.79-2.65]), and in @entity0 40-49 years (HR 2.03 [95% CI 1.73-2.39]). Lower extremity @entity3 comprised a higher proportion of incident @entity3 in @entity0 with versus those without type 1 @entity1 (31.1% vs. 25.1% in males, 39.3% vs. 32% in females; P < 0.001). Secondary analyses for incident @entity2 identified the highest HR of 5.64 (95% CI 3.55-8.97) in @entity0 60-69 years and the highest HR of 5.63 (95% CI 2.25-14.11) in @entity0 30-39 years. CONCLUSIONS: Type 1 @entity1 was associated with increased risk of incident @entity3 that began in childhood and extended across the life span. @entity0 with type 1 @entity1 sustained a disproportionately greater number of lower extremity @entity3 . These findings have important public health implications, given the increasing prevalence of type 1 @entity1 and the morbidity and mortality associated with @entity2 .

title: Type 1 @entity1 Is Associated With an Increased Risk of XXXX Across the Life Span: A Population-Based Cohort Study Using @entity4 ( @entity4 ).

answer: @entity3


abstract: OBJECTIVE: This study was conducted to determine if type 1 @entity1 is associated with an increased risk of @entity3 across the life span. RESEARCH DESIGN AND METHODS: This population-based cohort study used data from @entity4 ( @entity4 ) in the U.K. (data from 1994 to 2012), in which 30,394 @entity0 aged 0-89 years with type 1 @entity1 were compared with 303,872 randomly selected age-, sex-, and practice-matched @entity0 without @entity1 . Cox regression analysis was used to determine hazard ratios (HRs) for incident @entity3 in @entity0 with type 1 @entity1 . RESULTS: A total of 334,266 @entity0 , median age 34 years, were monitored for 1.9 million @entity0 -years. HR were lowest in males and females age <20 years, with HR 1.14 (95% CI 1.01-1.29) and 1.35 (95% CI 1.12-1.63), respectively. Risk was highest in @entity0 60-69 years (HR 2.18 [95% CI 1.79-2.65]), and in @entity0 40-49 years (HR 2.03 [95% CI 1.73-2.39]). Lower extremity @entity3 comprised a higher proportion of incident @entity3 in @entity0 with versus those without type 1 @entity1 (31.1% vs. 25.1% in males, 39.3% vs. 32% in females; P < 0.001). Secondary analyses for incident @entity2 identified the highest HR of 5.64 (95% CI 3.55-8.97) in @entity0 60-69 years and the highest HR of 5.63 (95% CI 2.25-14.11) in @entity0 30-39 years. CONCLUSIONS: Type 1 @entity1 was associated with increased risk of incident @entity3 that began in childhood and extended across the life span. @entity0 with type 1 @entity1 sustained a disproportionately greater number of lower extremity @entity3 . These findings have important public health implications, given the increasing prevalence of type 1 @entity1 and the morbidity and mortality associated with @entity2 .

title: Type 1 @entity1 Is Associated With an Increased Risk of @entity3 Across the Life Span: A Population-Based Cohort Study Using XXXX ( @entity4 ).

answer: @entity4


abstract: OBJECTIVE: This study was conducted to determine if type 1 @entity1 is associated with an increased risk of @entity3 across the life span. RESEARCH DESIGN AND METHODS: This population-based cohort study used data from @entity4 ( @entity4 ) in the U.K. (data from 1994 to 2012), in which 30,394 @entity0 aged 0-89 years with type 1 @entity1 were compared with 303,872 randomly selected age-, sex-, and practice-matched @entity0 without @entity1 . Cox regression analysis was used to determine hazard ratios (HRs) for incident @entity3 in @entity0 with type 1 @entity1 . RESULTS: A total of 334,266 @entity0 , median age 34 years, were monitored for 1.9 million @entity0 -years. HR were lowest in males and females age <20 years, with HR 1.14 (95% CI 1.01-1.29) and 1.35 (95% CI 1.12-1.63), respectively. Risk was highest in @entity0 60-69 years (HR 2.18 [95% CI 1.79-2.65]), and in @entity0 40-49 years (HR 2.03 [95% CI 1.73-2.39]). Lower extremity @entity3 comprised a higher proportion of incident @entity3 in @entity0 with versus those without type 1 @entity1 (31.1% vs. 25.1% in males, 39.3% vs. 32% in females; P < 0.001). Secondary analyses for incident @entity2 identified the highest HR of 5.64 (95% CI 3.55-8.97) in @entity0 60-69 years and the highest HR of 5.63 (95% CI 2.25-14.11) in @entity0 30-39 years. CONCLUSIONS: Type 1 @entity1 was associated with increased risk of incident @entity3 that began in childhood and extended across the life span. @entity0 with type 1 @entity1 sustained a disproportionately greater number of lower extremity @entity3 . These findings have important public health implications, given the increasing prevalence of type 1 @entity1 and the morbidity and mortality associated with @entity2 .

title: Type 1 @entity1 Is Associated With an Increased Risk of @entity3 Across the Life Span: A Population-Based Cohort Study Using @entity4 ( XXXX ).

answer: @entity4


abstract: OBJECTIVE: This study was conducted to determine if type 1 @entity1 is associated with an increased risk of @entity3 across the life span. RESEARCH DESIGN AND METHODS: This population-based cohort study used data from @entity4 ( @entity4 ) in the U.K. (data from 1994 to 2012), in which 30,394 @entity0 aged 0-89 years with type 1 @entity1 were compared with 303,872 randomly selected age-, sex-, and practice-matched @entity0 without @entity1 . Cox regression analysis was used to determine hazard ratios (HRs) for incident @entity3 in @entity0 with type 1 @entity1 . RESULTS: A total of 334,266 @entity0 , median age 34 years, were monitored for 1.9 million @entity0 -years. HR were lowest in males and females age <20 years, with HR 1.14 (95% CI 1.01-1.29) and 1.35 (95% CI 1.12-1.63), respectively. Risk was highest in @entity0 60-69 years (HR 2.18 [95% CI 1.79-2.65]), and in @entity0 40-49 years (HR 2.03 [95% CI 1.73-2.39]). Lower extremity @entity3 comprised a higher proportion of incident @entity3 in @entity0 with versus those without type 1 @entity1 (31.1% vs. 25.1% in males, 39.3% vs. 32% in females; P < 0.001). Secondary analyses for incident @entity2 identified the highest HR of 5.64 (95% CI 3.55-8.97) in @entity0 60-69 years and the highest HR of 5.63 (95% CI 2.25-14.11) in @entity0 30-39 years. CONCLUSIONS: Type 1 @entity1 was associated with increased risk of incident @entity3 that began in childhood and extended across the life span. @entity0 with type 1 @entity1 sustained a disproportionately greater number of lower extremity @entity3 . These findings have important public health implications, given the increasing prevalence of type 1 @entity1 and the morbidity and mortality associated with @entity2 .

title: Type 1 XXXX Is Associated With an Increased Risk of @entity3 Across the Life Span: A Population-Based Cohort Study Using @entity4 ( @entity4 ).

answer: @entity1


abstract: In North America and Europe, the binary toxin positive @entity3 strains of the ribotypes 027 and 078 have been associated with @entity1 , toxic @entity2 and other adverse outcomes. Following an increase in @entity3 infections (CDIs) in Queensland, a prevalence study involving 175 hospitals was undertaken in early 2012, identifying 168 cases of @entity4 over a 2 month period. @entity0 demographics and clinical characteristics were recorded, and @entity3 isolates were ribotyped and tested for the presence of binary toxin genes. Most @entity0 (106/168, 63.1_#37;) were aged over 60 years. Overall, 98 (58.3_#37;) developed symptoms after hospitalisation; 89 cases (53.0_#37;) developed symptoms more than 48 hours after admission. Furthermore, 27 of the 62 (67.7_#37;) @entity0 who developed symptoms in the community ad been hospitalised within the last 3 months. Thirteen of the 168 (7.7_#37;) cases identified had severe disease, resulting in admission to the Intensive Care Unit or @entity1 within 30 days of the onset of symptoms. The 3 most common ribotypes isolated were UK 002 (22.9_#37;), UK 014 (13.3_#37;) and the binary toxin-positive ribotype UK 244 (8.4_#37;). The only other binary toxin positive ribotype isolated was UK 078 (n = 1). Of concern was the detection of the binary toxin positive ribotype UK 244, which has recently been described in other parts of Australia and New Zealand. No isolates were of the international epidemic clone of ribotype UK 027, although ribotype UK 244 is genetically related to this clone. Further studies are required to track the epidemiology of ribotype UK 244 in Australia and New Zealand. Commun Dis Intell 2014;38(4):E279-E284.

title: Surveillance snapshot of XXXX infection in hospitals across Queensland detects binary toxin producing ribotype UK 244.

answer: @entity3


abstract: The transmembrane protein CRB3A controls epithelial cell polarization. Elucidating the molecular mechanisms of CRB3A function is essential as this protein prevents the epithelial-to-mesenchymal transition (EMT), which contributes to @entity0 progression. To investigate the functional impact of altered CRB3A expression in @entity0 cells, we expressed CRB3A in HeLa cells, which are devoid of endogenous CRB3A. While control HeLa cells display a patchy F-actin distribution, CRB3A-expressing cells form a circumferential actomyosin belt. This reorganization of the cytoskeleton is accompanied by a transition from an ameboid cell shape to an epithelial-cell-like morphology. In addition, CRB3A increases the cohesion of HeLa cells. To perform these functions, CRB3A recruits @entity5 and its activator @entity3 to the cell periphery using both functional motifs of its cytoplasmic tail and increases @entity1 activation levels. @entity2 and @entity4 ( @entity6 ), which are critical effectors of @entity1 , are also essential to modulate the cytoskeleton and cell shape downstream of CRB3A. Overall, our study highlights novel roles for CRB3A and deciphers the signaling pathway conferring to CRB3A the ability to fulfill these functions. Thereby, our data will facilitate further investigation of CRB3A functions and increase our understanding of the cellular defects associated with the loss of CRB3A expression in @entity0 cells.

title: CRB3A Controls the Morphology and Cohesion of Cancer Cells through XXXX / @entity5 -Dependent Signaling.

answer: @entity3


abstract: The transmembrane protein CRB3A controls epithelial cell polarization. Elucidating the molecular mechanisms of CRB3A function is essential as this protein prevents the epithelial-to-mesenchymal transition (EMT), which contributes to @entity0 progression. To investigate the functional impact of altered CRB3A expression in @entity0 cells, we expressed CRB3A in HeLa cells, which are devoid of endogenous CRB3A. While control HeLa cells display a patchy F-actin distribution, CRB3A-expressing cells form a circumferential actomyosin belt. This reorganization of the cytoskeleton is accompanied by a transition from an ameboid cell shape to an epithelial-cell-like morphology. In addition, CRB3A increases the cohesion of HeLa cells. To perform these functions, CRB3A recruits @entity5 and its activator @entity3 to the cell periphery using both functional motifs of its cytoplasmic tail and increases @entity1 activation levels. @entity2 and @entity4 ( @entity6 ), which are critical effectors of @entity1 , are also essential to modulate the cytoskeleton and cell shape downstream of CRB3A. Overall, our study highlights novel roles for CRB3A and deciphers the signaling pathway conferring to CRB3A the ability to fulfill these functions. Thereby, our data will facilitate further investigation of CRB3A functions and increase our understanding of the cellular defects associated with the loss of CRB3A expression in @entity0 cells.

title: CRB3A Controls the Morphology and Cohesion of Cancer Cells through @entity3 / XXXX -Dependent Signaling.

answer: @entity5


abstract: OBJECTIVE: Coarctation of the descending thoracic aorta is uncommon, with controversial etiology. Usually, severe @entity0 is the main symptom; lower @entity1 is less often found. Surgical management remains the standard for long @entity2 and provides good results. METHODS: We  report three cases of @entity2 of the descending aorta operated at our department of cardiovascular surgery of Hospital La Rabta between January 2012  and December 2013. RESULTS: The median age was 19  years and the median follow-up was 16  months. @entity0 was the most common clinical manifestation. The diagnosis was made by computed tomography angiography. Two cases were treated by an aorto-aortic bypass and one by subclavian-descending aorta bypass. Recovery was excellent, with a decrease in antihypertensive medications (four to two) and restoration of all distal pulses. CONCLUSIONS: Middle @entity2 is a rare entity. Etiologies include congenital, acquired, inflammatory and infectious causes. The condition is considered a life-threatening emergency as a result of the complications associated with severe @entity0 . Depending on technical considerations, open surgical bypass remains the standard repair for @entity3 .

title: [Middle XXXX : A rare vascular disorder.]

answer: @entity2


abstract: BACKGROUND: @entity0 with @entity1 ( @entity1 ) often report inadequate access to comprehensive @entity0 education resources. OBJECTIVE: The purpose of this study was to incorporate community-engagement principles within a mixed-method research design to evaluate the usability and acceptability of a self-tailored social media resource center for medically underserved @entity0 with @entity1 . METHODS: A multiphase sequential design (qual  >  QUANT  >  quant + QUAL) was incorporated into the current study, whereby a small-scale qualitative (qual) study informed the design of a social media website prototype that was tested with @entity0 during a computer-based usability study (QUANT). To identify usability violations and determine whether or not @entity0 found the website prototype acceptable for use, each @entity0 was asked to complete an 18-item website usability and acceptability questionnaire, as well as a retrospective, in-depth, semistructured interview (quant + QUAL). RESULTS: The majority of medically underserved @entity0 with @entity1 (n=8, mean 56 years, SD 7) found the social media website prototype to be easy to navigate and relevant to their self-management information needs. Mean responses on the 18-item website usability and acceptability questionnaire were very high on a scale of 1 (strongly disagree) to 5 (strongly agree) (mean 4.72, SD 0.33). However, the majority of @entity0 identified several usability violations related to the prototype's information design, interactive capabilities, and navigational structure. Specifically, 6 out of 8 (75%) @entity0 struggled to create a log-in account to access the prototype, and 7 out of 8 @entity0 (88%) experienced difficulty posting and replying to comments on an interactive discussion forum. CONCLUSIONS: @entity0 perceptions of most social media website prototype features (eg, clickable picture-based screenshots of videos, comment tools) were largely positive. Mixed-method stakeholder feedback was used to make design recommendations, categorize usability violations, and prioritize potential solutions for improving the usability of a social media resource center for @entity1 @entity0 education.

title: Engaging community stakeholders to evaluate the design, usability, and acceptability of a XXXX social media resource center.

answer: @entity1


abstract: PURPOSE: @entity3 ( @entity3 ) is a rare benign neoplasm that occurs almost exclusively in the nasopharynx of adolescent male individuals. METHODS: We performed a retrospective study to determine the efficacy and safety of preoperative embolization and the surgical outcome in @entity0 with @entity3 in a single-center institution. Fifteen cases undergoing embolization and surgical treatment between April 2003 and February 2013 were evaluated retrospectively. The demographic data, clinical presentation, and treatment were reviewed including the kind of preoperative embolization and different surgical approaches performed. The parameters investigated were the amount of @entity2 , the @entity1 stage, and the rates of recurrence. Subsequently, a comparison was made between @entity0 who had undergone Onyx(  ) embolization versus those who had been embolized with the standard approach. RESULTS: In these 15 @entity0 (mean age, 15 years), a total of 27 surgical procedures were performed. One @entity0 was at stage Ia, two were at stage Ib, two were at stage IIa, six were at stage IIb, one was at stage IIc, and three were at stage IIIa based on the Radkowsky classification. All @entity0 underwent preoperative embolization and subsequent surgery. The surgical approach and the embolization technique varied and evolved during time. The embolization procedure decreased the intraoperative @entity2 to a minimum of 250  ml, and with the advent of intratumoral embolization, the rate of recurrence diminished. CONCLUSION: Preoperative Onyx(  ) embolization facilitates the shift in the treatment to endoscopic excision in selected @entity0 , which reduces recurrence rates and overall morbidity.

title: Preoperative Embolization to Improve the Surgical Management and Outcome of @entity3 ( XXXX ) in a Single Center: 10-Year Experience.

answer: @entity3


abstract: PURPOSE: @entity3 ( @entity3 ) is a rare benign neoplasm that occurs almost exclusively in the nasopharynx of adolescent male individuals. METHODS: We performed a retrospective study to determine the efficacy and safety of preoperative embolization and the surgical outcome in @entity0 with @entity3 in a single-center institution. Fifteen cases undergoing embolization and surgical treatment between April 2003 and February 2013 were evaluated retrospectively. The demographic data, clinical presentation, and treatment were reviewed including the kind of preoperative embolization and different surgical approaches performed. The parameters investigated were the amount of @entity2 , the @entity1 stage, and the rates of recurrence. Subsequently, a comparison was made between @entity0 who had undergone Onyx(  ) embolization versus those who had been embolized with the standard approach. RESULTS: In these 15 @entity0 (mean age, 15 years), a total of 27 surgical procedures were performed. One @entity0 was at stage Ia, two were at stage Ib, two were at stage IIa, six were at stage IIb, one was at stage IIc, and three were at stage IIIa based on the Radkowsky classification. All @entity0 underwent preoperative embolization and subsequent surgery. The surgical approach and the embolization technique varied and evolved during time. The embolization procedure decreased the intraoperative @entity2 to a minimum of 250  ml, and with the advent of intratumoral embolization, the rate of recurrence diminished. CONCLUSION: Preoperative Onyx(  ) embolization facilitates the shift in the treatment to endoscopic excision in selected @entity0 , which reduces recurrence rates and overall morbidity.

title: Preoperative Embolization to Improve the Surgical Management and Outcome of XXXX ( @entity3 ) in a Single Center: 10-Year Experience.

answer: @entity3


abstract: @entity0 with @entity3 ( @entity3 ) show @entity1 and production of spoken language, and can also present with motor, auditory, and phonological difficulties. Recent auditory studies have shown impaired sensitivity to amplitude rise time (ART) in @entity0 with @entity3 , along with non-speech rhythmic timing difficulties. Linguistically, these @entity1 should affect sensitivity to speech prosody and syllable stress. Here we used two tasks requiring sensitivity to prosodic structure, the DeeDee task and a stress misperception task, to investigate this hypothesis. We also measured auditory processing of ART, rising pitch and sound duration, in both speech ("ba") and non-speech (tone) stimuli. @entity0 were 45 @entity0 with @entity5 aged on average 9 years and 50 age-matched controls. We report data for all the @entity5 @entity0 (N = 45, IQ varying), as well as for two independent @entity5 subgroupings with intact IQ. One subgroup, "Pure @entity5 ," had intact phonology and reading (N = 16), the other, " @entity5 @entity4 " (N = 15), had impaired phonology and reading. Problems with syllable stress and prosodic structure were found for all the group comparisons. Both sub-groups with intact IQ showed reduced sensitivity to ART in speech stimuli, but the @entity4 subgroup also showed reduced sensitivity to sound duration in speech stimuli. Individual differences in processing syllable stress were associated with auditory processing. These data support a new hypothesis, the "prosodic phrasing" hypothesis, which proposes that grammatical difficulties in @entity5 may reflect perceptual difficulties with global prosodic structure related to @entity2 in processing amplitude rise time and duration.

title: Basic auditory processing and sensitivity to prosodic structure in @entity0 with XXXX : a new look at a perceptual hypothesis.

answer: @entity3


abstract: @entity0 with @entity3 ( @entity3 ) show @entity1 and production of spoken language, and can also present with motor, auditory, and phonological difficulties. Recent auditory studies have shown impaired sensitivity to amplitude rise time (ART) in @entity0 with @entity3 , along with non-speech rhythmic timing difficulties. Linguistically, these @entity1 should affect sensitivity to speech prosody and syllable stress. Here we used two tasks requiring sensitivity to prosodic structure, the DeeDee task and a stress misperception task, to investigate this hypothesis. We also measured auditory processing of ART, rising pitch and sound duration, in both speech ("ba") and non-speech (tone) stimuli. @entity0 were 45 @entity0 with @entity5 aged on average 9 years and 50 age-matched controls. We report data for all the @entity5 @entity0 (N = 45, IQ varying), as well as for two independent @entity5 subgroupings with intact IQ. One subgroup, "Pure @entity5 ," had intact phonology and reading (N = 16), the other, " @entity5 @entity4 " (N = 15), had impaired phonology and reading. Problems with syllable stress and prosodic structure were found for all the group comparisons. Both sub-groups with intact IQ showed reduced sensitivity to ART in speech stimuli, but the @entity4 subgroup also showed reduced sensitivity to sound duration in speech stimuli. Individual differences in processing syllable stress were associated with auditory processing. These data support a new hypothesis, the "prosodic phrasing" hypothesis, which proposes that grammatical difficulties in @entity5 may reflect perceptual difficulties with global prosodic structure related to @entity2 in processing amplitude rise time and duration.

title: Basic auditory processing and sensitivity to prosodic structure in XXXX with @entity3 : a new look at a perceptual hypothesis.

answer: @entity0


abstract: UNASSIGNED: The aim of the current study was to determine how a control temperature and acute and chronic high eggshell temperatures during the last three days of incubation, can affect hatchability, @entity1 quality, and organ development on day of hatch as well as broiler performance and @entity0 incidence in later life. The eggshell temperature manipulations were applied during hatching term (days 19 to 21) as follows: control EST (37.3 to 38.0  C), acute high eggshell temperature manipulations (38.4- to 39.0  C for three hours daily) and chronic high eggshell temperature manipulations (38.4 to 39.0  C). The lowest hatchability and the highest cull @entity1 rate were in the chronic high eggshell temperature manipulations group. Lower @entity1 quality parameters correlated with lower @entity1 weights and heavier residual yolk sac weights that were in the chronic high eggshell temperature manipulations group depending on hatch time. The live weights on the 1(st) day of the growing period were higher in the control and acute high eggshell temperature manipulations groups than the chronic high eggshell temperature manipulations group. At 6 wk of age, live weights of broilers were the highest in the control than in the acute and chronic high eggshell temperature manipulations groups. The total mortality was 2.5, 9.2, and 13.3%, the mortality due to @entity0 was 2.1, 8.3, and 12.9% in the control, acute ,and chronic high eggshell temperature manipulations groups, respectively. The right ventricular/total ventricular ratios for the control, acute and chronic high eggshell temperature manipulations groups were 0.22, 0.28, and 0.30%, respectively. In conclusion, short-term and long-term higher temperatures during the hatching term affect embryo development, incubation results, broiler performance, and @entity0 incidence. Although the acute high eggshell temperature manipulations did not affect the @entity1 quality parameters at hatch, it negatively affected incubation results and broiler performance, especially mortality due to @entity0 .

title: Acute and chronic eggshell temperature manipulations during hatching term influence hatchability, broiler performance, and XXXX incidence.

answer: @entity0


abstract: A comparative study of @entity0 dying acutely and non-acutely from @entity2 was performed. The average age of the acute @entity1 group was significantly lower than the non-acute @entity1 group. There is no difference between the average age at @entity1 of the latter and that of those @entity0 who died from non-coronary causes. The majority of @entity0 with @entity5 ( @entity5 ) died a @entity6 . This proportion is especially high among males under 50. Taking into account the different manifestations of @entity5 most males and females with @entity6 died as a consequence of acute @entity2 . In the group of non-acute coronary deaths, acute and recurrent @entity4 dominated as the cause of @entity1 . @entity7 was less frequent in the acute compared to the non-acute @entity1 group. There was no significant difference in the frequency of @entity8 between the two groups. Severe @entity3 was substantially more frequent in the acute group compared with the non-acute.

title: [Comparative studies of sudden and @entity6 due to XXXX ].

answer: @entity2


abstract: A comparative study of @entity0 dying acutely and non-acutely from @entity2 was performed. The average age of the acute @entity1 group was significantly lower than the non-acute @entity1 group. There is no difference between the average age at @entity1 of the latter and that of those @entity0 who died from non-coronary causes. The majority of @entity0 with @entity5 ( @entity5 ) died a @entity6 . This proportion is especially high among males under 50. Taking into account the different manifestations of @entity5 most males and females with @entity6 died as a consequence of acute @entity2 . In the group of non-acute coronary deaths, acute and recurrent @entity4 dominated as the cause of @entity1 . @entity7 was less frequent in the acute compared to the non-acute @entity1 group. There was no significant difference in the frequency of @entity8 between the two groups. Severe @entity3 was substantially more frequent in the acute group compared with the non-acute.

title: [Comparative studies of sudden and XXXX due to @entity2 ].

answer: @entity6


abstract: BACKGROUND: Fracture sequelae of @entity2 arise following nonoperative and operative forms of treatment. Due to a painful restricted range of motion, in most cases shoulder prostheses are implanted. There is a need for joint-preserving alternatives especially for younger @entity0 . OBJECTIVES: The aim of this study was to evaluate the surgical techniques and prospective results of @entity1 sequelae of @entity2 following corrective osteosynthesis. MATERIAL AND METHODS: A total of 11  @entity0 (4 female) with an average age of 53 years (range 29-71 years) and a mean follow-up of 19.5 months were included prospectively. The preoperative and postoperative ranges of motion of the affected shoulder were compared by statistical means. At the time of follow-up the constant score (CS), the simple shoulder test (SST) and the simple shoulder value ( @entity3 ) were assessed. RESULTS: Fracture sequelae were classified as type II in four @entity0 , as type III in two and as type IV in five @entity0 using the Boileau classification. Shoulder flexion (p   =   0.006), abduction (p   =   0.003) and external rotation (p   =   0.02) improved significantly in the postoperative course. The mean age and gender-adapted CS was 74.8        19.9   % at the time of follow-up, 10.1 out of 12  points were reached in the SST and the mean @entity3 was 77   %. CONCLUSION: Corrective osteosynthesis of @entity1 sequelae (Boileau types II-IV) of @entity2 appears to be a good alternative to implantation of shoulder prostheses, especially in younger @entity0 (<   60  years of age).

title: [Corrective osteosynthesis of XXXX : Technique and prospective results].

answer: @entity2


abstract: The DNA contents of 33 @entity2 from @entity0 with @entity4 were analysed with flow-cytofluorometry. Degrees of ploidy and the proliferation rate, expressed as percentage of cells in S-phase, were determined. The aim was to compare these morphological and functional @entity1 properties with clinical and laboratory parameters to establish a possible relation and to further elucidate the characteristics of these @entity1 . In 15 @entity1 (45%) diploid DNA pattern were found, while 18 (55%) showed varying degrees of @entity3 . The frequency of cells in S-phase showed wide variations and were equally distributed in diploid and @entity1 . Duration of symptoms, age at diagnosis, preoperative @entity5 ( @entity5 )- and prolactin (Prl)-levels, @entity1 size and grade of invasive @entity1 growth as determined by radiological estimations, did not correlate to ploidy or grade of proliferation. The lack of correlation between DNA pattern and proliferation rate in relation to clinical, laboratory and radiological parameters in @entity1 causing @entity4 contrasts to the documented relation between the degree of ploidy, cells in proliferation and grade of @entity1 reported in @entity1 of other sites. The 55% aneuploid @entity5 producing @entity1 indicate a certain malignant transformation. The high frequency of cells in S-phase in several @entity5 secreting @entity1 completes the malignant morphological and functional cell properties. The benign character of @entity1 causing @entity4 is therefore in contrast to these findings. The lack of clinical significance of the DNA pattern and the frequency of cells in proliferation in @entity5 producing @entity1 and the benign character despite malignant cell properties in most of these @entity1 are difficult to explain.(ABSTRACT TRUNCATED AT 250 WORDS)

title: DNA and S-phase representation in @entity0 XXXX producing @entity2 .

answer: @entity5


abstract: The DNA contents of 33 @entity2 from @entity0 with @entity4 were analysed with flow-cytofluorometry. Degrees of ploidy and the proliferation rate, expressed as percentage of cells in S-phase, were determined. The aim was to compare these morphological and functional @entity1 properties with clinical and laboratory parameters to establish a possible relation and to further elucidate the characteristics of these @entity1 . In 15 @entity1 (45%) diploid DNA pattern were found, while 18 (55%) showed varying degrees of @entity3 . The frequency of cells in S-phase showed wide variations and were equally distributed in diploid and @entity1 . Duration of symptoms, age at diagnosis, preoperative @entity5 ( @entity5 )- and prolactin (Prl)-levels, @entity1 size and grade of invasive @entity1 growth as determined by radiological estimations, did not correlate to ploidy or grade of proliferation. The lack of correlation between DNA pattern and proliferation rate in relation to clinical, laboratory and radiological parameters in @entity1 causing @entity4 contrasts to the documented relation between the degree of ploidy, cells in proliferation and grade of @entity1 reported in @entity1 of other sites. The 55% aneuploid @entity5 producing @entity1 indicate a certain malignant transformation. The high frequency of cells in S-phase in several @entity5 secreting @entity1 completes the malignant morphological and functional cell properties. The benign character of @entity1 causing @entity4 is therefore in contrast to these findings. The lack of clinical significance of the DNA pattern and the frequency of cells in proliferation in @entity5 producing @entity1 and the benign character despite malignant cell properties in most of these @entity1 are difficult to explain.(ABSTRACT TRUNCATED AT 250 WORDS)

title: DNA and S-phase representation in @entity0 @entity5 producing XXXX .

answer: @entity2


abstract: The DNA contents of 33 @entity2 from @entity0 with @entity4 were analysed with flow-cytofluorometry. Degrees of ploidy and the proliferation rate, expressed as percentage of cells in S-phase, were determined. The aim was to compare these morphological and functional @entity1 properties with clinical and laboratory parameters to establish a possible relation and to further elucidate the characteristics of these @entity1 . In 15 @entity1 (45%) diploid DNA pattern were found, while 18 (55%) showed varying degrees of @entity3 . The frequency of cells in S-phase showed wide variations and were equally distributed in diploid and @entity1 . Duration of symptoms, age at diagnosis, preoperative @entity5 ( @entity5 )- and prolactin (Prl)-levels, @entity1 size and grade of invasive @entity1 growth as determined by radiological estimations, did not correlate to ploidy or grade of proliferation. The lack of correlation between DNA pattern and proliferation rate in relation to clinical, laboratory and radiological parameters in @entity1 causing @entity4 contrasts to the documented relation between the degree of ploidy, cells in proliferation and grade of @entity1 reported in @entity1 of other sites. The 55% aneuploid @entity5 producing @entity1 indicate a certain malignant transformation. The high frequency of cells in S-phase in several @entity5 secreting @entity1 completes the malignant morphological and functional cell properties. The benign character of @entity1 causing @entity4 is therefore in contrast to these findings. The lack of clinical significance of the DNA pattern and the frequency of cells in proliferation in @entity5 producing @entity1 and the benign character despite malignant cell properties in most of these @entity1 are difficult to explain.(ABSTRACT TRUNCATED AT 250 WORDS)

title: DNA and S-phase representation in XXXX @entity5 producing @entity2 .

answer: @entity0