abstract: @entity1 are often associated with dry skin and loss of epidermal barrier integrity. In this study, repeated application of @entity5 and @entity6 followed by water (AEW) to the cheek skin of @entity0 produced persistent scratching behavior with no increase in @entity3 , indicating the generation of itch without @entity3 . Cheek skin immunohistochemistry showed a 64.5% increase in total epidermal innervation in AEW-treated @entity0 compared to water-treated controls. This increase was independent of scratching, because @entity0 prevented from scratching by Elizabethan collars showed similar hyperinnervation. To determine the effects of dry skin treatment on specific subsets of peripheral fibers, we examined Ret-positive, @entity8 ( @entity8 )-positive, and glial cell line-derived neurotrophic factor family receptor a3 ( @entity7 )-positive intraepidermal fiber density. AEW treatment increased Ret-positive fibers but not @entity8 -positive or @entity7 -positive fibers, suggesting that a specific subset of nonpeptidergic fibers could contribute to dry skin itch. To test whether trigeminal ganglion neurons innervating the cheek exhibited altered excitability after AEW treatment, primary cultures of retrogradely labeled neurons were examined using whole-cell patch clamp electrophysiology. AEW treatment produced no differences in measures of excitability compared to water-treated controls. In contrast, a significantly higher proportion of trigeminal ganglion neurons was responsive to the nonhistaminergic pruritogen @entity4 after AEW treatment. We conclude that nonpeptidergic, Ret-positive fibers and @entity4 -sensitive neurons may contribute to dry skin @entity2 . PERSPECTIVE: This study examines the underlying neurobiological mechanisms of persistent dry skin itch. Our results indicate that nonpeptidergic epidermal hyperinnervation and nonhistaminergic pruritic receptors are potential targets for chronic @entity2 .

title: Enhanced nonpeptidergic intraepidermal fiber density and an expanded subset of @entity4 -responsive trigeminal neurons in a XXXX model of dry skin itch.

answer: @entity0


abstract: BACKGROUND: The purpose of this study was to assess the the efficacy of oral @entity4 ( @entity6 ) in prevention of acute radiation-induced @entity5 in @entity0 with @entity1 and determine the predictive role of clinical and dosimetric parameters. MATERIALS AND METHODS: Thirty-two @entity0 diagnosed with @entity1 were studied prospectively. Sixteen @entity0 (50%) received prophylactic powdered @entity6 orally in doses of 10g/8h. @entity0 were treated 2 Gy per fraction daily, 5 days a week. We evaluated the grading of @entity5 daily at the end of each fraction of each treatment day until a cumulative dose of 50 Gy was reached. The primary end point was radiation-induced @entity5 . RESULTS: All @entity0 tolerated @entity6 well. @entity2 grade, @entity3 , serum cytokine levels and esophageal transit times exhibited statistically significant improvement in the @entity6 receiving group. @entity6 suppressed the inflammation related to the disease and treatment and reduced @entity2 with statistical significance. CONCLUSIONS: This study suggests a benefical role of oral @entity6 use in prevention and/or delay of radiation-induced @entity5 , in terms of esophageal transit time and serum immunological parameters, as well as @entity3 .

title: Oral @entity4 Supplementation Reduces Radiotherapy- induced @entity5 in XXXX @entity0 .

answer: @entity1


abstract: BACKGROUND: The purpose of this study was to assess the the efficacy of oral @entity4 ( @entity6 ) in prevention of acute radiation-induced @entity5 in @entity0 with @entity1 and determine the predictive role of clinical and dosimetric parameters. MATERIALS AND METHODS: Thirty-two @entity0 diagnosed with @entity1 were studied prospectively. Sixteen @entity0 (50%) received prophylactic powdered @entity6 orally in doses of 10g/8h. @entity0 were treated 2 Gy per fraction daily, 5 days a week. We evaluated the grading of @entity5 daily at the end of each fraction of each treatment day until a cumulative dose of 50 Gy was reached. The primary end point was radiation-induced @entity5 . RESULTS: All @entity0 tolerated @entity6 well. @entity2 grade, @entity3 , serum cytokine levels and esophageal transit times exhibited statistically significant improvement in the @entity6 receiving group. @entity6 suppressed the inflammation related to the disease and treatment and reduced @entity2 with statistical significance. CONCLUSIONS: This study suggests a benefical role of oral @entity6 use in prevention and/or delay of radiation-induced @entity5 , in terms of esophageal transit time and serum immunological parameters, as well as @entity3 .

title: Oral @entity4 Supplementation Reduces Radiotherapy- induced XXXX in @entity1 @entity0 .

answer: @entity5


abstract: BACKGROUND: The purpose of this study was to assess the the efficacy of oral @entity4 ( @entity6 ) in prevention of acute radiation-induced @entity5 in @entity0 with @entity1 and determine the predictive role of clinical and dosimetric parameters. MATERIALS AND METHODS: Thirty-two @entity0 diagnosed with @entity1 were studied prospectively. Sixteen @entity0 (50%) received prophylactic powdered @entity6 orally in doses of 10g/8h. @entity0 were treated 2 Gy per fraction daily, 5 days a week. We evaluated the grading of @entity5 daily at the end of each fraction of each treatment day until a cumulative dose of 50 Gy was reached. The primary end point was radiation-induced @entity5 . RESULTS: All @entity0 tolerated @entity6 well. @entity2 grade, @entity3 , serum cytokine levels and esophageal transit times exhibited statistically significant improvement in the @entity6 receiving group. @entity6 suppressed the inflammation related to the disease and treatment and reduced @entity2 with statistical significance. CONCLUSIONS: This study suggests a benefical role of oral @entity6 use in prevention and/or delay of radiation-induced @entity5 , in terms of esophageal transit time and serum immunological parameters, as well as @entity3 .

title: Oral XXXX Supplementation Reduces Radiotherapy- induced @entity5 in @entity1 @entity0 .

answer: @entity4


abstract: BACKGROUND: The purpose of this study was to assess the the efficacy of oral @entity4 ( @entity6 ) in prevention of acute radiation-induced @entity5 in @entity0 with @entity1 and determine the predictive role of clinical and dosimetric parameters. MATERIALS AND METHODS: Thirty-two @entity0 diagnosed with @entity1 were studied prospectively. Sixteen @entity0 (50%) received prophylactic powdered @entity6 orally in doses of 10g/8h. @entity0 were treated 2 Gy per fraction daily, 5 days a week. We evaluated the grading of @entity5 daily at the end of each fraction of each treatment day until a cumulative dose of 50 Gy was reached. The primary end point was radiation-induced @entity5 . RESULTS: All @entity0 tolerated @entity6 well. @entity2 grade, @entity3 , serum cytokine levels and esophageal transit times exhibited statistically significant improvement in the @entity6 receiving group. @entity6 suppressed the inflammation related to the disease and treatment and reduced @entity2 with statistical significance. CONCLUSIONS: This study suggests a benefical role of oral @entity6 use in prevention and/or delay of radiation-induced @entity5 , in terms of esophageal transit time and serum immunological parameters, as well as @entity3 .

title: Oral @entity4 Supplementation Reduces Radiotherapy- induced @entity5 in @entity1 XXXX .

answer: @entity0


abstract: PURPOSE: To evaluate if @entity5 ( @entity5 ) exposes neonates delivered after 34 weeks to an increased risk of severe @entity1 ( @entity1 ). METHODS: Data from 3,237 @entity0 who delivered after 34 weeks with systematic screening for @entity5 were analyzed. Diagnosis of severe @entity1 required the association of clinical and radiological criteria with a minimum of 24 h of ventilation and admission to neonatal intensive care unit. RESULTS: A total of 166 (5.1%) cases of @entity5 were identified. Severe @entity1 was diagnosed in 7 (4.21%) cases among @entity0 with @entity5 as compared to 13 (0.42%) in others (p < 0.001). The rate of severe @entity1 was also significantly higher in cases of @entity4 (p < 0.001), @entity2 (p < 0.001), and cesarean section (p = 0.005). After adjustment for these variables, @entity5 was identified as an independent risk factor for @entity1 (AOR 11.55, 95% CI 3.9-33.9, p < 0.001). Two other risk factors were also identified: late @entity3 (AOR 6.13, 95% CI 1.8-21.2, p = 0.004); and hypotrophy (AOR 9.16, 95% CI 2.7-30.5, p < 0.001). CONCLUSIONS: @entity5 is an independent risk factor for severe @entity1 after 34 weeks. Neonates from such pregnancies should be monitored carefully.

title: Gestational diabetes: a strong independent risk factor for severe XXXX after 34 weeks.

answer: @entity1


abstract: OBJECTIVE: The present study aims to document the experience of a single center on the reproductive outcome of a cohort of @entity0 who were treated with conservative surgery for @entity2 and to specify whether their fertility potential is associated with age, @entity1 histology and surgery type. METHODS: A total of 55 @entity0 who had undergone conservative surgery for @entity2 between January 1999 and January 2009 were eligible. Recurrence rate, fertility outcome and the number of pregnancies were analyzed retrospectively. RESULTS: Among the study group, 11 @entity0 were not sexually active both at the time of surgery and during the follow-up period. Thus, a total of 44 @entity0 attempted pregnancy after conservative surgery and 52.3% of them (23 out of 44) were able to conceive either spontaneously or by in vitro fertilization. The ability to conceive was shown to be associated with age, @entity1 histology and type of conservative surgery. As expected, the fertility potential correlated positively with decreasing age (correlation coefficient = 0.705, p = 0.001). Moreover, the existence of non-serous histology and the implementation of unilateral cystectomy were found to be associated with the ability to reach a clinical pregnancy (correlation coefficient = 0.585, p = 0.001 and correlation coefficient = 0.587, p = 0.001, respectively). CONCLUSIONS: The primary treatment of @entity2 refers to conservative surgery. Younger age, non-serous histology and unilateral cystectomy appear to be associated with favorable reproductive outcome in @entity0 who undergo conservative surgery for borderline @entity1 of ovary.

title: Fertility outcome after conservative surgery for XXXX : a single center experience.

answer: @entity2


abstract: @entity8 ( @entity8 ) and @entity4 ( @entity4 ) are clinically and pathologically distinct and both are locally invasive. However, while @entity8 rarely metastasise, @entity4 have the potential to do so especially when they arise on the ears or lips. UV radiation is the most important risk factor for @entity6 ( @entity6 ). The @entity1 most commonly arise in fair-skinned individuals on sun-damaged skin, especially the face. Incidence rises with age. @entity0 with one @entity6 have a higher risk of developing another @entity6 and of @entity3 . @entity4 are frequently more difficult to diagnose than @entity8 . Well differentiated lesions have a pronounced keratotic element. Poorly differentiated @entity4 tend to be pink or red papules or nodules, lacking keratin, which may ulcerate. Around 5% of @entity4 metastasise. High-risk @entity4 include those: on the ear, lip, or sites unexposed to the sun and in chronic @entity5 , scars or @entity7 . @entity4 > 20 mm in diameter or > 4 mm in depth are high risk. @entity0 who are immunosuppressed, have poorly differentiated @entity1 or recurrent disease are also at increased risk. @entity0 with a slowly evolving or persistent @entity2 where @entity1 is a possibility should be referred to a dermatologist. Lesions suspected of being BCC should be referred routinely. Urgent referral should be reserved for cases where there is concern that a delay may have a significant impact because of the size or site of the lesion. Any non-healing lesions >1 cm with marked induration on palpation, showing significant expansion over eight weeks, should be referred urgently as they may be @entity4 .

title: Improving detection of XXXX @entity6 .

answer: @entity6


abstract: @entity8 ( @entity8 ) and @entity4 ( @entity4 ) are clinically and pathologically distinct and both are locally invasive. However, while @entity8 rarely metastasise, @entity4 have the potential to do so especially when they arise on the ears or lips. UV radiation is the most important risk factor for @entity6 ( @entity6 ). The @entity1 most commonly arise in fair-skinned individuals on sun-damaged skin, especially the face. Incidence rises with age. @entity0 with one @entity6 have a higher risk of developing another @entity6 and of @entity3 . @entity4 are frequently more difficult to diagnose than @entity8 . Well differentiated lesions have a pronounced keratotic element. Poorly differentiated @entity4 tend to be pink or red papules or nodules, lacking keratin, which may ulcerate. Around 5% of @entity4 metastasise. High-risk @entity4 include those: on the ear, lip, or sites unexposed to the sun and in chronic @entity5 , scars or @entity7 . @entity4 > 20 mm in diameter or > 4 mm in depth are high risk. @entity0 who are immunosuppressed, have poorly differentiated @entity1 or recurrent disease are also at increased risk. @entity0 with a slowly evolving or persistent @entity2 where @entity1 is a possibility should be referred to a dermatologist. Lesions suspected of being BCC should be referred routinely. Urgent referral should be reserved for cases where there is concern that a delay may have a significant impact because of the size or site of the lesion. Any non-healing lesions >1 cm with marked induration on palpation, showing significant expansion over eight weeks, should be referred urgently as they may be @entity4 .

title: Improving detection of @entity6 XXXX .

answer: @entity6


abstract: BACKGROUND: Only one prospective randomized study on the extent of mesial resection in surgery for @entity3 ( @entity3 ) exists. This randomized controlled trial (RCT) examines whether 3.5-cm mesial resection is leading to a better @entity2 outcome than a 2.5-cm resection. METHODS: Three @entity1 surgery centers using similar MRI protocols, neuropsychological tests, and resection types for @entity3 surgery included 207 @entity0 in a RCT with pre- and postoperative volumetrics. One hundred and four @entity0 were randomized into a 2.5-cm resection group and 103 @entity0 into a 3.5-cm resection group, i.e., an intended minimum resection length of 25 versus 35 mm for the hippocampus and parahippocampus. Primary outcome measure was @entity2 freedom Engel class I throughout the first year. The study was powered to detect a 20% difference in class I outcome. @entity2 outcome was available for 207 @entity0 , complete volumetric results for 179 @entity0 . Outcome analysis was restricted to control of successful randomization and an intent-to-treat analysis of @entity2 outcome. RESULTS: The mean true resection volumes were significantly different for the 2.5-cm and 3.5-cm resection groups; thus, the randomization was successful. Median resection volume in the 2.5-cm group was 72.86% of initial volume and 83.44% in the 3.5-cm group. At 1 year, @entity2 outcome Engel class I was 74% in the 2.5-cm and 72.8% in the 3.5-cm resection group. CONCLUSIONS: The primary intent-to-treat analysis did not show a different @entity2 freedom rate for the more posteriorly reaching 3.5-cm resection group. It appears possible that not maximal volume resection but adequate volume resection leads to good @entity2 freedom.

title: Randomized controlled trial of 2.5-cm versus 3.5-cm mesial temporal resection in XXXX --Part 1: intent-to-treat analysis.

answer: @entity3


abstract: BACKGROUND: Observational studies evaluating the possible interaction between proton pump inhibitors (PPIs) and @entity6 have shown mixed results. We conducted a systematic review comparing the safety of individual PPIs in @entity0 with @entity3 taking @entity6 . METHODS AND RESULTS: Studies performed from January 1995 to December 2013 were screened for inclusion. Data were extracted, and study quality was graded for 34 potential studies. For those studies in which follow-up period, outcomes, and multivariable adjustment were comparable, meta-analysis was performed.The adjusted odds or hazard ratios for the composite of cardiovascular or all-cause @entity2 , @entity4 , and @entity1 at 1 year were reported in 6 observational studies with data on individual PPIs. Random-effects meta-analyses of the 6 studies revealed an increased risk for adverse cardiovascular events for those taking @entity11 (hazard ratio 1.38; 95% CI 1.12-1.70), @entity10 (hazard ratio 1.29; 95% CI 1.09-1.52), or @entity7 (hazard ratio 1.27; 95% CI 1.02-1.58) compared with @entity0 on no PPI. This association was not significant for @entity8 (hazard ratio 1.16; 95% CI 0.93-1.44). Sensitivity analyses for the @entity3 ( @entity5 versus mixed) and exclusion of a single study due to heterogeneity of reported results did not have significant influence on the effect estimates for any PPIs. CONCLUSIONS: Several frequently used PPIs previously thought to be safe for concomitant use with @entity6 were associated with greater risk of adverse cardiovascular events. Although the data are observational, they highlight the need for randomized controlled trials to evaluate the safety of concomitant @entity9 and @entity6 use in @entity0 with @entity3 .

title: Individual Proton Pump Inhibitors and Outcomes in @entity0 With XXXX on Dual Antiplatelet Therapy: A Systematic Review.

answer: @entity3


abstract: BACKGROUND: Observational studies evaluating the possible interaction between proton pump inhibitors (PPIs) and @entity6 have shown mixed results. We conducted a systematic review comparing the safety of individual PPIs in @entity0 with @entity3 taking @entity6 . METHODS AND RESULTS: Studies performed from January 1995 to December 2013 were screened for inclusion. Data were extracted, and study quality was graded for 34 potential studies. For those studies in which follow-up period, outcomes, and multivariable adjustment were comparable, meta-analysis was performed.The adjusted odds or hazard ratios for the composite of cardiovascular or all-cause @entity2 , @entity4 , and @entity1 at 1 year were reported in 6 observational studies with data on individual PPIs. Random-effects meta-analyses of the 6 studies revealed an increased risk for adverse cardiovascular events for those taking @entity11 (hazard ratio 1.38; 95% CI 1.12-1.70), @entity10 (hazard ratio 1.29; 95% CI 1.09-1.52), or @entity7 (hazard ratio 1.27; 95% CI 1.02-1.58) compared with @entity0 on no PPI. This association was not significant for @entity8 (hazard ratio 1.16; 95% CI 0.93-1.44). Sensitivity analyses for the @entity3 ( @entity5 versus mixed) and exclusion of a single study due to heterogeneity of reported results did not have significant influence on the effect estimates for any PPIs. CONCLUSIONS: Several frequently used PPIs previously thought to be safe for concomitant use with @entity6 were associated with greater risk of adverse cardiovascular events. Although the data are observational, they highlight the need for randomized controlled trials to evaluate the safety of concomitant @entity9 and @entity6 use in @entity0 with @entity3 .

title: Individual Proton Pump Inhibitors and Outcomes in XXXX With @entity3 on Dual Antiplatelet Therapy: A Systematic Review.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: There are few in vivo data on the pathophysiology of reperfusion during systemic thrombolysis. We monitored the time course of cerebral perfusion changes in @entity0 during thrombolysis with repeated arterial @entity3 labeling perfusion magnetic resonance imaging. METHODS: Ten @entity0 with proximal @entity2 within 4.5 hours after symptom onset were prospectively enrolled. All @entity0 received intravenous thrombolysis during the magnetic resonance imaging examination. Repeated arterial @entity3 labeling perfusion images were acquired during the 60-minute therapy and at follow-up after 24 to 72 hours. Clinical data, magnetic resonance imaging features, and cerebral perfusion changes were analyzed. RESULTS: Before thrombolysis, arterial @entity3 labeling hypoperfusion and fluid-attenuation inversion recovery vascular hyperintensity in the territory of the occluded arteries were observed in all @entity0 . In 5 @entity0 , extensive arterial transit artifacts (ATA) developed in the hypoperfused area. The ATA corresponded with fluid-attenuation inversion recovery vascular hyperintensities. All 5 @entity0 who developed extensive ATA in the hypoperfused area had complete reperfusion after thrombolysis, whereas the 5 without extensive ATA showed no or only partial reperfusion (P<0.01). The development of ATA preceded the normalization of tissue perfusion. CONCLUSIONS: The development of ATA during thrombolysis is associated with early reperfusion after thrombolysis. arterial @entity3 labeling assessment during intravenous thrombolysis has the potential to guide subsequent therapeutic strategies in @entity0 with @entity1 .

title: Prediction of Early Reperfusion From Repeated Arterial XXXX Labeling Perfusion Magnetic Resonance Imaging During Intravenous Thrombolysis.

answer: @entity3


abstract: BACKGROUND: @entity1 is diagnosed by a set of clinical criteria and therefore is probably heterogeneous. Earlier reports tested the hypothesis that the syndrome had a neurological substrate by doing studies of cerebral blood flow (CBF) but with discrepant results. One possible reason for the discrepancy was that relative CBF was assessed. We found reduced CBF in an earlier study of absolute CBF using xenon-CT. The purpose of this study was to use a second method of assessing CBF and to look within the study group for heterogeneity of responses. METHOD: Eleven CFS @entity0 and 10 age matched healthy controls underwent neuroimaging using arterial spin labeling to determine their regional and global absolute CBF. A template was constructed based on the control data, and individual @entity0 montages were compared on a case by case basis to determine if differences in regions of interest occurred. RESULTS: The @entity0 as a group had significantly lower global CBF than the controls. The reduction in CBF occurred across nearly every region assessed. Nine of the 11 @entity0 showed these reductions compared to the average control data, while two @entity0 showed actual increases relative to the controls. CONCLUSION: The data extend our earlier observation that CFS @entity0 as a group have broad decreases in CBF compared to healthy controls. However, as expected, the effect was not homogeneous in that 2 of the 11 @entity0 studied showed actual increases in CBF relative to controls.

title: Cerebral blood flow is reduced in XXXX as assessed by arterial spin labeling.

answer: @entity1


abstract: PURPOSE: A new hemoadsorption device intended as adjunctive treatment for @entity0 with elevated cytokine levels in the setting of SIRS and @entity2 has shown promising results. We report on the beneficial application of the device in a @entity0 with @entity8 receiving combined extracorporeal life support with rECMO, LVAD, and CVVH despite his highly septic condition. METHODS: A 39-year-old @entity0 presented with fulminant @entity3 and @entity8 . A veno-arterial ECMO was implanted for circulatory support. During the course of @entity1 , the @entity0 developed @entity6 in addition to his @entity5 , making initiation of CVVH necessary. Due to a complete @entity7 in both ventricles, a left ventricular assist device (LVAD) in combination with right ECMO (rECMO) was implanted despite manifest septic conditions. In the post-operative course @entity4 levels and vasopressor dosages increased drastically. A CytoSorb hemoadsorption device was therefore installed in the CVVH circuit and 3 sessions were run during the following 4 days. RESULTS: During CytoSorb treatment, inflammatory markers @entity4 , @entity10 , and @entity9 decreased concomitant with significantly reduced vasopressor support. No adverse device-related side effects were documented during or after the treatment sessions. CONCLUSIONS: This is the first clinical case report of a highly septic @entity0 treated with the combined use of LVAD, rECMO, CVVH, and CytoSorb. The combination was practical, technically feasible, and beneficial for the @entity0 . This combination represents a reasonable approach to improve survival in @entity0 with multiple organ dysfunction necessitating several organ supportive techniques.

title: First successful combination of ECMO with cytokine removal therapy in XXXX : a case report.

answer: @entity8


abstract: UNASSIGNED: @entity4 , a class IA antiarrhythmic drug (AAD), has been used for the treatment of @entity1 since the early 1900s. Use has decreased recently because of the availability of newer AADs and concerns about side effects and safety. @entity4 can cause @entity2 , and @entity0 have @entity2 and are more susceptible to @entity3 ( @entity3 ) than are @entity0 . We sought to evaluate the influence of gender on @entity4 tolerability, safety, and efficacy. We performed retrospective analyses of @entity0 at our institution prescribed @entity4 as an AAD between 2000 and 2012. Time to @entity4 discontinuation and @entity1 recurrence were evaluated using Cox proportional hazards models. In 179 @entity0 , 23.5% were @entity0 and median age was 65.8  years. @entity4 indication was @entity1 in 68.7% and @entity1 in 27.9% of @entity0 . At 3  years after @entity4 initiation, Kaplan-Meier probability of @entity4 discontinuation was 65.7% for @entity0 and 82.4% for @entity0 (p  = 0.015). @entity0 were more likely than @entity0 to discontinue @entity4 for @entity2 (14.3 vs 4.4%, p  = 0.036) and @entity3 (4.8 vs 0%, p  =  0.054). After multivariate adjustment, female gender remained independently associated with @entity4 discontinuation (adjusted hazard ratio 1.97, p  = 0.014). Gender had no influence on @entity1 recurrence: 1  year after @entity4 initiation, Kaplan-Meier probability of freedom from recurrent @entity1 was 62.4% in @entity0 and 57.9% in @entity0 (p  = 0.33). @entity4 is highly effective in both genders. However, @entity0 are more likely than @entity0 to experience @entity2 and @entity3 on @entity4 and are more likely to discontinue @entity4 independent of these side effects.

title: Influence of Gender on the Tolerability, Safety, and Efficacy of @entity4 Used for Treatment of Supraventricular and XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity4 , a class IA antiarrhythmic drug (AAD), has been used for the treatment of @entity1 since the early 1900s. Use has decreased recently because of the availability of newer AADs and concerns about side effects and safety. @entity4 can cause @entity2 , and @entity0 have @entity2 and are more susceptible to @entity3 ( @entity3 ) than are @entity0 . We sought to evaluate the influence of gender on @entity4 tolerability, safety, and efficacy. We performed retrospective analyses of @entity0 at our institution prescribed @entity4 as an AAD between 2000 and 2012. Time to @entity4 discontinuation and @entity1 recurrence were evaluated using Cox proportional hazards models. In 179 @entity0 , 23.5% were @entity0 and median age was 65.8  years. @entity4 indication was @entity1 in 68.7% and @entity1 in 27.9% of @entity0 . At 3  years after @entity4 initiation, Kaplan-Meier probability of @entity4 discontinuation was 65.7% for @entity0 and 82.4% for @entity0 (p  = 0.015). @entity0 were more likely than @entity0 to discontinue @entity4 for @entity2 (14.3 vs 4.4%, p  = 0.036) and @entity3 (4.8 vs 0%, p  =  0.054). After multivariate adjustment, female gender remained independently associated with @entity4 discontinuation (adjusted hazard ratio 1.97, p  = 0.014). Gender had no influence on @entity1 recurrence: 1  year after @entity4 initiation, Kaplan-Meier probability of freedom from recurrent @entity1 was 62.4% in @entity0 and 57.9% in @entity0 (p  = 0.33). @entity4 is highly effective in both genders. However, @entity0 are more likely than @entity0 to experience @entity2 and @entity3 on @entity4 and are more likely to discontinue @entity4 independent of these side effects.

title: Influence of Gender on the Tolerability, Safety, and Efficacy of XXXX Used for Treatment of Supraventricular and @entity1 .

answer: @entity4


abstract: UNASSIGNED: Interview with Professor Madhukar @entity2 , @entity1 , PhD by Claire Raison (Commissioning Editor) Professor Madhukar @entity2 did his medical training and community medicine residency in Vellore, India. He completed his PhD in epidemiology at the University of California, Berkeley (CA, USA) and a postdoctoral fellowship at the University of California, San Francisco (CA, USA). He is currently an associate professor of epidemiology at McGill University in Montreal (Canada). He serves as the Director of Global Health Programs, and as an Associate Director of the McGill International @entity0 Centre. In addition, he serves as a Consultant for the Bill _ Melinda Gates Foundation. He also serves on the Scientific Advisory Committee of the Foundation for Innovative New Diagnostics, Geneva, Switzerland. His research is focused on improving the diagnosis and treatment of @entity0 , especially in high-burden countries such as India and South Africa. His research is supported by grant funding from the Gates Foundation, Grand Challenges Canada and Canadian Institutes of Health Research. He has more than 200 peer-reviewed publications. He is recipient of the Union Scientific Prize, Chanchlani Global Health Research Award and Stars in Global Health award from Grand Challenges Canada, and is a member of the Royal Society of Canada.

title: Transforming the diagnosis of XXXX : an editorial board member's opinion at the 15th year of Expert Review of Molecular Diagnostics.

answer: @entity0


abstract: The present study was designed to evaluate how environmental factors in a dry-summer subtropical climate in Terceira-Azores (situated in the North Atlantic Ocean: 38   43' N 27   12' W) can affect dairy @entity1 (Holstein) fertility, as well as seasonal influence on in vitro oocytes maturation and embryos development. Impact of @entity2 ( @entity2 ) effects on in vitro oocyte's maturation and further embryo development after @entity0 ( @entity0 ) was also evaluated. For such purpose the result of the first artificial insemination (AI) performed 60 to 90 days after calving of 6,300 @entity1 were recorded for one year. In parallel, climatic data was obtained at different elevation points (n = 5) from 0 to 1,000 m and grazing points from 0 to 500 m, in Terceira island, and the temperature humidity index (THI) was calculated. For in vitro experiments, oocytes (n = 706) were collected weekly during all year, for meiotic maturation and @entity0 . Further, to evaluate @entity2 effect, 891 oocytes were collected in the cold moths (December, January, February and March) and divided in three groups treated to @entity2 for 24 h during in vitro maturation at: C (Control = 38.5  C), HS1 (39.5  C) and HS2 (40.5  C). Oocytes from each group were used for meiotic assessment and @entity0 . Cleavage, morula and blastocyst development were evaluated respectively on day 2, 6, and 9 after @entity0 . A negative correlation between @entity1 's conception rate (CR) and THI in grazing points (-91.3%; p<0.001) was observed. Mean THI in warmer months (June, July, August and September) was 71.7  0.7 and the CR (40.2  1.5%) while in cold months THI was 62.8  0.2 and CR was 63.8  0.4%. A similar impact was obtained with in vitro results in which nuclear maturation rate (NMR) ranged from 78.4% (  8.0) to 44.3% (  8.1), while embryos development ranged from 53.8% (  5.8) to 36.3% (  3.3) in cold and warmer months respectively. In vitro @entity2 results showed a significant decline (p<0.05) on NMR of oocytes for every 1  C rising temperature (78.4  8.0, 21.7  3.1 and 8.9  2.2, respectively for C, HS1, and HS2). Similar results were observed in cleavage rate and embryo development, showing a clear correlation (96.9 p<0.05) between NMR and embryo development with respect to temperatures. Results clearly demonstrated that, up to a THI of 70.6, a decrease in the CR occurs in first AI after calving; this impairment was confirmed with in vitro results.

title: Reproductive Performance of Holstein Dairy XXXX Grazing in Dry-summer Subtropical Climatic Conditions: Effect of Heat Stress and @entity2 on Meiotic Competence and In vitro Fertilization.

answer: @entity1


abstract: The present study was designed to evaluate how environmental factors in a dry-summer subtropical climate in Terceira-Azores (situated in the North Atlantic Ocean: 38   43' N 27   12' W) can affect dairy @entity1 (Holstein) fertility, as well as seasonal influence on in vitro oocytes maturation and embryos development. Impact of @entity2 ( @entity2 ) effects on in vitro oocyte's maturation and further embryo development after @entity0 ( @entity0 ) was also evaluated. For such purpose the result of the first artificial insemination (AI) performed 60 to 90 days after calving of 6,300 @entity1 were recorded for one year. In parallel, climatic data was obtained at different elevation points (n = 5) from 0 to 1,000 m and grazing points from 0 to 500 m, in Terceira island, and the temperature humidity index (THI) was calculated. For in vitro experiments, oocytes (n = 706) were collected weekly during all year, for meiotic maturation and @entity0 . Further, to evaluate @entity2 effect, 891 oocytes were collected in the cold moths (December, January, February and March) and divided in three groups treated to @entity2 for 24 h during in vitro maturation at: C (Control = 38.5  C), HS1 (39.5  C) and HS2 (40.5  C). Oocytes from each group were used for meiotic assessment and @entity0 . Cleavage, morula and blastocyst development were evaluated respectively on day 2, 6, and 9 after @entity0 . A negative correlation between @entity1 's conception rate (CR) and THI in grazing points (-91.3%; p<0.001) was observed. Mean THI in warmer months (June, July, August and September) was 71.7  0.7 and the CR (40.2  1.5%) while in cold months THI was 62.8  0.2 and CR was 63.8  0.4%. A similar impact was obtained with in vitro results in which nuclear maturation rate (NMR) ranged from 78.4% (  8.0) to 44.3% (  8.1), while embryos development ranged from 53.8% (  5.8) to 36.3% (  3.3) in cold and warmer months respectively. In vitro @entity2 results showed a significant decline (p<0.05) on NMR of oocytes for every 1  C rising temperature (78.4  8.0, 21.7  3.1 and 8.9  2.2, respectively for C, HS1, and HS2). Similar results were observed in cleavage rate and embryo development, showing a clear correlation (96.9 p<0.05) between NMR and embryo development with respect to temperatures. Results clearly demonstrated that, up to a THI of 70.6, a decrease in the CR occurs in first AI after calving; this impairment was confirmed with in vitro results.

title: Reproductive Performance of Holstein Dairy @entity1 Grazing in Dry-summer Subtropical Climatic Conditions: Effect of Heat Stress and XXXX on Meiotic Competence and In vitro Fertilization.

answer: @entity2


abstract: BACKGROUND: @entity1 use in various forms, including with Areca nut, causes several potentially malignant disorders. Many lesions may transform into @entity3 . Although @entity0 may be aware of the hazards of @entity1 habits, the lesions by themselves are insidious in nature resulting in failure of @entity0 to present to general dentists/specialists at early stages. Our aim was to study the types of habits prevalent in the region of Rourkela in Orissa and to assess the insidious nature of the lesions associated with these habits. Not many studies have been done from this part of India. MATERIALS AND METHODS: A camp was conducted for habitual users of @entity1 and its products, Areca nut and other mixed habit users. A thorough history was taken of the type, duration and frequency of habits, symptoms of @entity0 along with clinical examination by a single examiner. The data was entered in detail into an excel sheet and analysed. RESULTS: 54.7% had lesions and 60.9 % of them were asymptomatic and rest had mild @entity2 while eating. There was a very low awareness of the presence of lesions among the @entity0 . CONCLUSIONS: There is a need to spread the awareness of the ill effects of the @entity1 and other associated habits far and wide and more importantly educate the general public on the appearance of associated lesions as these are almost always insidious in nature. The @entity0 can self-examine, detect lesions early when present and approach the dentist at the earliest opportunity.

title: Sneak Peek into XXXX Habits and Associated Insidious Oral Lesions in an Odisha Sample Population.

answer: @entity1


abstract: The @entity0 -antagonist @entity3 was infused intravenously in ten @entity1 using dosage rates of 0.5 to 3 micrograms kg-1 min-1. The reactions of pial arterial and venous vessels as well as @entity2 ( @entity2 ) were studied. For analysis of pial vascular reactions, diameter variations were continuously monitored on 50 arterial and 22 venous portions using a multichannel videoangiometer. At 0.5 micrograms kg-1 min-1, pial arteries with a mean resting diameter of 81 microns dilated by 4% (p less than 0.0005); venous diameters decreased by 0.5% (n.s.); @entity2 declined by 2% (n.s.). At 1 microgram kg-1 min-1, arteries dilated by 25% (p less than 0.0005), venous diameters were diminished by 3.8% (n.s.), @entity2 decreased by 9% (n.s.). Further significant dilatation of pial arteries was observed at 2 and 3 micrograms kg-1 min-1, however, together with a significant fall of @entity2 . Arterial vessels smaller than 60 micrograms resting diameter dilated more than arteries above 60 micrograms. After the infusion was stopped, arterial dilatation by some 20% persisted for at least 20 minutes, even when @entity2 values returned to the resting level.

title: Pial arterial and venous reaction to intravenous infusion of XXXX in @entity1 .

answer: @entity3


abstract: The @entity0 -antagonist @entity3 was infused intravenously in ten @entity1 using dosage rates of 0.5 to 3 micrograms kg-1 min-1. The reactions of pial arterial and venous vessels as well as @entity2 ( @entity2 ) were studied. For analysis of pial vascular reactions, diameter variations were continuously monitored on 50 arterial and 22 venous portions using a multichannel videoangiometer. At 0.5 micrograms kg-1 min-1, pial arteries with a mean resting diameter of 81 microns dilated by 4% (p less than 0.0005); venous diameters decreased by 0.5% (n.s.); @entity2 declined by 2% (n.s.). At 1 microgram kg-1 min-1, arteries dilated by 25% (p less than 0.0005), venous diameters were diminished by 3.8% (n.s.), @entity2 decreased by 9% (n.s.). Further significant dilatation of pial arteries was observed at 2 and 3 micrograms kg-1 min-1, however, together with a significant fall of @entity2 . Arterial vessels smaller than 60 micrograms resting diameter dilated more than arteries above 60 micrograms. After the infusion was stopped, arterial dilatation by some 20% persisted for at least 20 minutes, even when @entity2 values returned to the resting level.

title: Pial arterial and venous reaction to intravenous infusion of @entity3 in XXXX .

answer: @entity1


abstract: AIM OF THE STUDY: @entity13 (AE) was isolated from Abacopteris penangiana (Hook.) Ching. This study was to elucidate its neuroprotective effects against @entity4 ( @entity5 ) induced oxidative damage in PC12 cells and @entity11 ( @entity12 ) induced @entity10 in @entity0 brain. MATERIALS AND METHODS: In vitro, the protective effect of AE against @entity5 -induced oxidative damage in the PC12 was investigated by the method of @entity1 ( @entity1 ). In vivo, the protective effect of AE against @entity12 -induced @entity10 in @entity0 was studied. The @entity0 in the model group and the AE treatment groups were injected with the @entity12 150 mg/(kg d) for 7 weeks while the @entity0 in the control group were injected with the same volume of saline (0.9%). From the sixth week, the treatment groups were subcutaneously injected 4 or 8 mg/(kg d) of AE. In order to explore the potential mechanism of AE's action, the @entity0 were assessed by behavioral and electrophysiological tests at the end of the administration. Then the @entity0 brain tissues were measured for the levels of @entity3 dismutases (SOD), @entity8 peroxidase ( @entity9 -Px), and @entity6 ( @entity7 ). RESULTS: This study showed that AE lowered the @entity5 -induced @entity2 , and AE significantly improved the learning and memory ability in behavioral performance. The biochemical examination revealed that AE restored the activities of SOD and @entity9 -Px, and attenuated the increase of @entity7 . Moreover, the electrophysiological analysis evidently showed that AE ameliorated the long-term potentiation (LTP). CONCLUSIONS: These results suggested that AE had neuroprotective effects, and its beneficial effects may be linked with inhibiting the generation of free radical and enhancing the activities of endogenous antioxidant enzymes.

title: Neuroprotective effects of @entity13 from Abacopteris penangiana against oxidative stress-induced XXXX .

answer: @entity10


abstract: AIM OF THE STUDY: @entity13 (AE) was isolated from Abacopteris penangiana (Hook.) Ching. This study was to elucidate its neuroprotective effects against @entity4 ( @entity5 ) induced oxidative damage in PC12 cells and @entity11 ( @entity12 ) induced @entity10 in @entity0 brain. MATERIALS AND METHODS: In vitro, the protective effect of AE against @entity5 -induced oxidative damage in the PC12 was investigated by the method of @entity1 ( @entity1 ). In vivo, the protective effect of AE against @entity12 -induced @entity10 in @entity0 was studied. The @entity0 in the model group and the AE treatment groups were injected with the @entity12 150 mg/(kg d) for 7 weeks while the @entity0 in the control group were injected with the same volume of saline (0.9%). From the sixth week, the treatment groups were subcutaneously injected 4 or 8 mg/(kg d) of AE. In order to explore the potential mechanism of AE's action, the @entity0 were assessed by behavioral and electrophysiological tests at the end of the administration. Then the @entity0 brain tissues were measured for the levels of @entity3 dismutases (SOD), @entity8 peroxidase ( @entity9 -Px), and @entity6 ( @entity7 ). RESULTS: This study showed that AE lowered the @entity5 -induced @entity2 , and AE significantly improved the learning and memory ability in behavioral performance. The biochemical examination revealed that AE restored the activities of SOD and @entity9 -Px, and attenuated the increase of @entity7 . Moreover, the electrophysiological analysis evidently showed that AE ameliorated the long-term potentiation (LTP). CONCLUSIONS: These results suggested that AE had neuroprotective effects, and its beneficial effects may be linked with inhibiting the generation of free radical and enhancing the activities of endogenous antioxidant enzymes.

title: Neuroprotective effects of XXXX from Abacopteris penangiana against oxidative stress-induced @entity10 .

answer: @entity13


abstract: BACKGROUND: Immune @entity3 is characterised by immune-mediated destruction and suboptimum production of platelets. Despite the absence of supporting evidence, rituximab is frequently used off-label in @entity0 with @entity4 . We aimed to assess the efficacy of rituximab as compared with placebo as a splenectomy-sparing treatment in @entity0 who were previously treated with @entity2 . METHODS: In this multicentre, randomised, double-masked, placebo-controlled trial, we enrolled corticosteroid unresponsive adult @entity0 (aged >= 18 years) with primary @entity4 and a platelet count of less than 30   *   10(9) platelets per L. @entity0 were randomly assigned (1:1) to four weekly infusions of 375 mg/m(2) rituximab or placebo. Concurrent treatment with @entity2 only was allowed during the study. The primary endpoint was rate of treatment failure within 78 weeks-a composite of splenectomy or meeting criteria for splenectomy after week 12 if splenectomy was not done, assessed in all @entity0 who received at least one dose of study treatment. Secondary endpoints were response rates, relapse rates, and duration of response. Efficacy endpoints were assessed with the Kaplan-Meier method. Safety endpoints were assessed in all @entity0 who received at least one dose. This trial is registered with ClinicalTrials.gov, number NCT00344149. FINDINGS: Between Aug 17, 2006, and June 30, 2011, we enrolled 112 @entity0 . 32 (58%) of 55 @entity0 in the rituximab group and 37 (69%) of 54 @entity0 in the placebo group had treatment failure within 78 weeks (Kaplan-Meier cumulative incidence 46% for rituximab vs 52% for placebo (hazard ratio [HR] 0  89, 95% CI 0  55-1  45; p=0  65). The cumulative incidence of overall response was 81% in the rituximab group versus 73% in the placebo group (p=0  15) and complete response was 58% in the rituximab group versus 50% in the placebo group (p=0  12). Of those achieving an overall response, 68% relapsed in the rituximab group and 78% relapsed in the placebo group, and of those achieving complete response, 50% relapsed in the rituximab group and 62% relapsed in the placebo group. Time to relapse in the rituximab group was longer in @entity0 who achieved overall response (36 vs 7 weeks; p=0  01) but not complete response (76 vs 49 weeks; p=0  19). Rates of bleeding were similar in the two groups (21 [38%] in the rituximab group vs 27 [50%] in the placebo group; p=0  08) as were rates of @entity1 (22 [40%] vs 13 [24%]; p=0  09). INTERPRETATION: Despite no reduction in the rate of long-term treatment failure with rituximab, a small benefit cannot be ruled out, as suggested by an apparently longer duration of response and numerically higher response rates with rituximab. FUNDING: South-East Regional Health Authority and   stfold Hospital, Norway; Roche, France; and Roche, Norway.

title: Rituximab as second-line treatment for adult XXXX (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial.

answer: @entity4


abstract: PURPOSE: To investigate the accuracy of the base-to-base prism test (BBPT), which entails inducing an @entity2 with the use of base-in prisms before each eye, in the diagnosis of @entity1 . METHODS: @entity0 were consecutive @entity0 recruited from a pediatric ophthalmology practice who were able to perform logMAR acuity testing. All @entity0 underwent an orthoptic examination, including logMAR visual acuity testing, and a sensorimotor evaluation. @entity0 with an interocular difference of 2 or more lines were considered to have @entity1 . Fixation preference was assessed by use of both the vertical fixation test and the BBPT. The agreement between the BBPT and visual acuity was analyzed and compared with the agreement between the vertical fixation test and visual acuity. RESULTS: Fifty-one consecutive @entity0 aged 4 to 17 (mean, 9.8 years; SD    3.4) were included, of whom 11 were diagnosed with @entity1 . Kappa analysis showed moderate but significant agreement between the BBPT and logMAR (k = 0.453, p = 0.001), whereas the vertical fixation test demonstrated only a fair agreement (k = 0.254, p = 0.061). The overall sensitivity for the BBPT was 72.7% (95% confidence interval [95% CI], 43.4%-90.3%) but only 40% for the vertical fixation test (95% CI, 16.8%-69.7%). For the BBPT, specificity was 80% (95% CI, 65.2%-89.5%); for the vertical fixation test, 78% (95% CI, 63.3%-88.0%). CONCLUSIONS: The BBPT appears to be more sensitive than the vertical fixation test for detecting @entity1 in our @entity0 population. The 2 tests had similar specificity.

title: The base-to-base induced-tropia prism test for detection of XXXX : a pilot study.

answer: @entity1


abstract: 1. Isolated sheets of @entity0 descending colon epithelial cells stripped from their underlying muscle coats were incubated in chambers at 37 degrees C with oxygenated media, and their non-inulin space water, @entity3 , @entity2 and @entity6 contents were subsequently determined. 2. With @entity3 Ringer bathing both surfaces, @entity7 , 10(-4) M, decreased non-inulin space @entity3 content by 76 mmol/kg dry wt. Ouabain, 10(-3) M, caused loss of non-inulin space @entity2 which was not completely compensated for by uptake of @entity3 over 30 min incubation. @entity6 and water, therefore, decreased. @entity7 , 10(-4) M, inhibited but did not prevent this uptake of @entity3 after ouabain. 3. Tissues exposed to @entity3 -free @entity4 Ringer rapidly exchanged non-inulin space @entity3 for @entity4 and, more slowly, lost @entity2 , @entity6 and water. The equilibration of @entity3 in the non-inulin space when @entity3 Ringer was restored to the mucosal medium alone was largely @entity7 -insensitive. For restoration of non-inulin space @entity2 to normal levels, @entity3 was required in the serosal but not the mucosal medium. 4. Neither the absence of @entity1 nor the absence of @entity6 from the mucosal medium affected the non-inulin space @entity3 content when @entity3 was restored to the mucosal medium bathing @entity3 -depleted tissues. 5. It is argued that, whereas non-inulin space @entity2 and water contents are synonymous with their cellular values, only about one third of non-inulin space @entity3 is cellular when @entity3 Ringer bathes both surfaces, and the concentration of the @entity3 within the cellular transport pool approximated 20 mmol/kg @entity5 , consistent with estimates obtained from other techniques.

title: Ions and water in the epithelial cells of XXXX descending colon.

answer: @entity0


abstract: Of fifteen @entity0 each five of them inhaled @entity1 ( @entity2 ) at the levels of 700, 1500 and 2,000 ppm respectively for one hour. Changes in @entity2 concentrations in the expired air, arterial blood and venous blood of @entity0 were measured from the beginning of exposure until one hour after the end of exposure. The results obtained were as follows. 1. Cumulative uptakes of @entity2 in one hour exposure were 27.3 mg/kg at 700 ppm, 44.7 mg/kg at 1,500 ppm and 71.2 mg/kg at 2,000 ppm. 2. Excretion ratios of @entity2 in one hour after the exposure were 66-71% at all the three levels of exposure. 3. During the exposure, highly significant negative correlation was seen between arterial/venous blood concentration ratio and expired/inspired air concentration ratio. In the post-exposure period, highly significant positive correlations were seen between expired air concentration and venous or arterial blood concentration. 4. The mean ratio of the total absorption value to the total inspired value was 14% at all the three levels of exposure. 5. From these results, the authors examined the multiple regression equations with two independent variables x and z which are shown as follows. a) During the exposure period, Y1: Cumulative absorption solvent value by the @entity0 (mg/kg) X1: Time of exposure (min) Z1: Level of the solvent value in the ambient air (microgram/ml) log Y1 = -0.526 + 0.622 log X1 + 0.905 log Z1 b) Post exposure period, Y2: Cumulative excreted solvent value by the @entity0 (mg/kg) X2: Time after the end of exposure (min) Z2: Cumulative absorbed solvent value by the @entity0 at the end of exposure (mg/kg) log Y2 = -2.300 + 0.609 log X2 + 0.858 log Z2 We assumed that both equations are very fit and significant.

title: [Experimental examinations and toxicokinetic analysis of the absorption and excretion of XXXX by the lung].

answer: @entity1


abstract: UNASSIGNED: Radical pericardiectomy alone is not effective in @entity0 with @entity1 accompanied by @entity2 . However, a waffle procedure is very effective in these @entity0 , as we demonstrate in this paper. Firstly, we performed a radical pericardiectomy via a median sternotomy. We used an ultrasonic scalpel for this procedure, and an apical suction device was useful for lifting the heart. This technique is similar to that used in off-pump coronary artery bypass grafting. After the whole heart was dissected from the markedly thickened parietal pericardium, a waffle procedure was performed on the left ventricle first. Multiple longitudinal and transverse incisions were made on the thickened epicardium using an ultrasonic scalpel. After the left ventricle was fully relieved of constriction, the same procedure was performed on the right ventricle. Thereafter, a remarkable improvement of our @entity0 's haemodynamic status was obtained. The whole procedure can be done without cardiopulmonary bypass. We describe tips for performing the waffle procedure without cardiopulmonary bypass using an ultrasonic scalpel and apical suction device, as well as pitfalls to avoid.

title: Off-pump waffle procedure using an ultrasonic scalpel for XXXX

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity3 ) is a common condition both in primary care and specialty clinics. PURPOSE: To evaluate the natural history (ie, incidence, recurrence, and progression to surgery) of @entity1 in a large population. STUDY DESIGN: Descriptive epidemiology study. METHODS: The study population comprised a population-based incidence cohort of @entity0 with new-onset @entity1 between January 1, 2000, and December 31, 2012. The medical records of a 10% random sample (n = 576) were reviewed to ascertain information on @entity0 and disease characteristics, treatment modalities, recurrence, and progression to surgery. Age- and sex-specific incidence rates were calculated and adjusted to the 2010 US population. RESULTS: The age- and sex-adjusted annual incidence of @entity1 decreased significantly over time from 4.5 per 1000 @entity0 in 2000 to 2.4 per 1000 in 2012 (P < .001). The recurrence rate within 2 years was 8.5% and remained constant over time. The proportion of surgically treated cases within 2 years of diagnosis tripled over time, from 1.1% during the 2000-2002 time period to 3.2% after 2009 (P < .00001). About 1 in 10 @entity0 with persistent symptoms at 6 months required surgery. CONCLUSION: The decrease in incidence of @entity1 may represent changes in diagnosis patterns or a true decrease in disease incidence. Natural history data can be used to help guide @entity0 and providers in determining the most appropriate course at a given time in the disease process. The study data suggest that @entity0 without resolution after 6 months of onset may have a @entity2 and may need surgical intervention.

title: The Epidemiology and Health Care Burden of XXXX : A Population-Based Study.

answer: @entity3


abstract: Lymphangiogenesis may be important for the cellular immune response in liver transplantation. In the present study, we examined lymphangiogenesis in liver allografts displaying acute cellular rejection (ACR), or long-term acceptance, or severe ACR plus antibody-mediated rejection (AMR). ACR and subsequent long-term graft acceptance developed in liver transplantations from DA to PVG @entity2 without immunosuppression (mean survival time more than 90 days). Severe ACR and AMR developed in liver transplantations from DA to Lewis @entity2 without immunosuppression (mean survival = 11 days). Normal DA donor livers before transplantation showed a small number of lymphatic vessels around portal veins. DA liver grafts in PVG showed ACR with lymphangiogenesis in portal areas and portal-portal bridging areas with cellular infiltration. Newly formed lymphatic vessels in ACR were characterized by proliferating endothelial cells with expression of the homeobox transcription factor @entity3 and surrounded by discontinuous basement membranes. Thereafter, the infiltrates spontaneously disappeared, and the grafts survived more than 90 days. During the resolution of the cellular infiltration, expanded lymphatic vessels were packed with many lymphocytes. Thereafter, the number of lymphatic vessels decreased. In contrast, severe ACR and AMR in DA-to-Lewis transplantations showed lymphatic vessels disappeared with @entity0 in the portal areas at day 11. In conclusion, lymphangiogenesis occurred during ACR. It may be involved in the resolution of ACR and @entity1 . In severe ACR and AMR, lymphatic vessels were destroyed, which may be involved in persistent severe @entity1 .

title: Lymphangiogenesis associated with acute cellular rejection in XXXX liver transplantation.

answer: @entity2


abstract: BACKGROUND: Previous studies suggest that @entity4 is efficacious in the treatment of @entity1 . OBJECTIVE: To evaluate the efficacy and safety of @entity4 in addition to @entity5 in improving hospitalization outcomes in @entity0 with @entity1 . METHODS: Hospital records of @entity0 evaluated for liver transplantation at a single center between January 2006 and May 2008 were reviewed. Hospitalizations for @entity1 and other conditions and the incidence of spontaneous @entity2 and adverse events were analyzed. RESULTS: Charts of 65 @entity0 who were treated with @entity4 and @entity5 were analyzed. @entity0 received @entity5 (20-120 g/d; @entity5 phase) before treatment with @entity4 (400- 1200 mg/d; @entity4 phase). During the @entity4 phase, the risk, number, and duration of hospitalizations for @entity1 were reduced compared with the @entity5 phase. Treatment, age, and Model for End-Stage @entity3 score were independent predictors of hospitalizations for @entity1 (P < .05). The @entity4 phase had fewer hospitalizations than the @entity5 phase (36 vs 47, respectively) and a smaller percentage of @entity0 with repeated hospitalizations than the @entity5 phase (5% vs 14%, respectively; P = .006) for conditions other than @entity1 . A smaller percentage of @entity0 had evidence of spontaneous @entity2 during the @entity4 phase than the @entity5 phase (2% vs 12%, respectively; P = .02). @entity4 was better tolerated than @entity5 . CONCLUSIONS: Addition of @entity4 to @entity5 therapy significantly reduced the risk and duration of hospitalizations for @entity1 .

title: @entity4 for the treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: Previous studies suggest that @entity4 is efficacious in the treatment of @entity1 . OBJECTIVE: To evaluate the efficacy and safety of @entity4 in addition to @entity5 in improving hospitalization outcomes in @entity0 with @entity1 . METHODS: Hospital records of @entity0 evaluated for liver transplantation at a single center between January 2006 and May 2008 were reviewed. Hospitalizations for @entity1 and other conditions and the incidence of spontaneous @entity2 and adverse events were analyzed. RESULTS: Charts of 65 @entity0 who were treated with @entity4 and @entity5 were analyzed. @entity0 received @entity5 (20-120 g/d; @entity5 phase) before treatment with @entity4 (400- 1200 mg/d; @entity4 phase). During the @entity4 phase, the risk, number, and duration of hospitalizations for @entity1 were reduced compared with the @entity5 phase. Treatment, age, and Model for End-Stage @entity3 score were independent predictors of hospitalizations for @entity1 (P < .05). The @entity4 phase had fewer hospitalizations than the @entity5 phase (36 vs 47, respectively) and a smaller percentage of @entity0 with repeated hospitalizations than the @entity5 phase (5% vs 14%, respectively; P = .006) for conditions other than @entity1 . A smaller percentage of @entity0 had evidence of spontaneous @entity2 during the @entity4 phase than the @entity5 phase (2% vs 12%, respectively; P = .02). @entity4 was better tolerated than @entity5 . CONCLUSIONS: Addition of @entity4 to @entity5 therapy significantly reduced the risk and duration of hospitalizations for @entity1 .

title: XXXX for the treatment of @entity1 .

answer: @entity4


abstract: AIM: The aim of the present study was to investigate the point prevalence of @entity4 and @entity1 ( @entity1 ) in @entity0 with @entity3 ( @entity3 ). METHODS: A total of 1200 @entity0 with @entity3 from 12 hospitals were included in the study. All @entity0 were grouped into normal cognition, @entity1 and @entity4 subgroups. General cognitive status and @entity4 severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical @entity4 Rating and Global Deterioration Scale, and @entity3 motor status was assessed by the Hoehn and Yahr staging score. Associated @entity2 and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed. RESULTS: @entity1 was frequent in @entity0 with @entity3 ; @entity1 was found in 38.9% of @entity0 , whereas @entity4 was in 38.3% of @entity0 . The prevalence of @entity1 increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking @entity5 movement @entity2 were associated with @entity1 . Many @entity4 @entity0 (95.2%) and 23.6% of @entity1 @entity0 were treated with antidementia drugs, with @entity6 the most frequently used. CONCLUSION: The point prevalence of @entity1 in @entity0 with @entity3 was 77.2%. @entity1 was associated with age, disease duration and specific @entity3 motor/non-motor symptoms. Over 90% of the @entity0 with @entity4 were treated with antidementia medication, and @entity6 was the most frequently used for the management of @entity4 . Geriatr Gerontol Int 2015;       :       -      .

title: Prevalence and treatment pattern of XXXX in Korea.

answer: @entity3


abstract: The most abundant carcinogen in @entity4 smoke or its condensate has been identified as @entity9 . This is formed predominantly from @entity7 in @entity4 during curing and smoking but may also be generated within the body. Intravenous injection of @entity8 NNN appears highly concentrated in the choroid of pigmented @entity2 . Like @entity7 , it crosses the placental barrier and appears in the choroid of the @entity6 in pregnant female @entity2 . Other studies of the male @entity5 population show a trend toward earlier life appearance of @entity5 in smokers and significantly less of disease-free @entity5 at five years among smokers. Immunoglobulin G and natural killer leukocyte activities appear to be reduced in male smokers with or without @entity5 . Although species and strain differences in susceptibility to carcinogenic agents are well known, these findings led us to a retrospective analysis of 126 white adults undergoing enucleation as immediate therapy for unilateral @entity5 between 1958 and 1978. Histologic verification and adequate follow-ups were obtained in 105 @entity0 . Minimum follow-up in 65 survivors was 3 years and maximum was 24 years. In 40 @entity0 with metastatic @entity5 , @entity3 occurred at 3 months to 13 years or at an average of 44 months following surgery. An adequate history of @entity4 use was obtained in 94 @entity0 , 44 of which were positive for @entity4 use (32 male; 12 female) and 50 were denials (16 male; 34 female). Questions to female @entity0 or families of deceased @entity0 evoked more prompt and uncompromising denial than was experienced in questioning of male @entity0 . Straight (non-actuarial) five @entity1 mortality in white males with @entity5 showed 12 of 32 or 37% dead among male smokers and 1 of 13 or 8% dead among male non-smokers. Actuarial calculation of five year survival showed only 62% in @entity4 using males and 85% in non- @entity4 using males. The distribution of cytology was essentially similar in groups both by sex and other subgroupings. There were, however, more @entity1 (greater than 10 mm in diameter) in the @entity4 group (61%) vs the non-smokers (31%). These preliminary findings merit further analysis by prospective @entity4 histories in @entity5 @entity0 , particularly among the male population.

title: Carcinogenesis and XXXX in @entity5 .

answer: @entity7


abstract: The most abundant carcinogen in @entity4 smoke or its condensate has been identified as @entity9 . This is formed predominantly from @entity7 in @entity4 during curing and smoking but may also be generated within the body. Intravenous injection of @entity8 NNN appears highly concentrated in the choroid of pigmented @entity2 . Like @entity7 , it crosses the placental barrier and appears in the choroid of the @entity6 in pregnant female @entity2 . Other studies of the male @entity5 population show a trend toward earlier life appearance of @entity5 in smokers and significantly less of disease-free @entity5 at five years among smokers. Immunoglobulin G and natural killer leukocyte activities appear to be reduced in male smokers with or without @entity5 . Although species and strain differences in susceptibility to carcinogenic agents are well known, these findings led us to a retrospective analysis of 126 white adults undergoing enucleation as immediate therapy for unilateral @entity5 between 1958 and 1978. Histologic verification and adequate follow-ups were obtained in 105 @entity0 . Minimum follow-up in 65 survivors was 3 years and maximum was 24 years. In 40 @entity0 with metastatic @entity5 , @entity3 occurred at 3 months to 13 years or at an average of 44 months following surgery. An adequate history of @entity4 use was obtained in 94 @entity0 , 44 of which were positive for @entity4 use (32 male; 12 female) and 50 were denials (16 male; 34 female). Questions to female @entity0 or families of deceased @entity0 evoked more prompt and uncompromising denial than was experienced in questioning of male @entity0 . Straight (non-actuarial) five @entity1 mortality in white males with @entity5 showed 12 of 32 or 37% dead among male smokers and 1 of 13 or 8% dead among male non-smokers. Actuarial calculation of five year survival showed only 62% in @entity4 using males and 85% in non- @entity4 using males. The distribution of cytology was essentially similar in groups both by sex and other subgroupings. There were, however, more @entity1 (greater than 10 mm in diameter) in the @entity4 group (61%) vs the non-smokers (31%). These preliminary findings merit further analysis by prospective @entity4 histories in @entity5 @entity0 , particularly among the male population.

title: Carcinogenesis and @entity7 in XXXX .

answer: @entity5


abstract: OBJECTIVE: To characterize the absolute risks for older @entity0 of readmission to hospital and @entity2 in the year after hospitalization for @entity4 , @entity3 , or @entity1 . DESIGN: Retrospective cohort study. SETTING: 4767 hospitals caring for Medicare fee for service beneficiaries in the United States, 2008-10. @entity0 : More than 3 million Medicare fee for service beneficiaries, aged 65 years or more, surviving hospitalization for @entity4 , @entity3 , or @entity1 . MAIN OUTCOME MEASURES: Daily absolute risks of first readmission to hospital and @entity2 for one year after discharge. To illustrate risk trajectories, we identified the time required for risks of readmission to hospital and @entity2 to decline 50% from maximum values after discharge; the time required for risks to approach plateau periods of minimal day to day change, defined as 95% reductions in daily changes in risk from maximum daily declines after discharge; and the extent to which risks are higher among @entity0 recently discharged from hospital compared with the general elderly population. RESULTS: Within one year of hospital discharge, readmission to hospital and @entity2 , respectively, occurred following 67.4% and 35.8% of hospitalizations for @entity4 , 49.9% and 25.1% for @entity3 , and 55.6% and 31.1% for @entity1 . Risk of first readmission had declined 50% by day 38 after hospitalization for @entity4 , day 13 after hospitalization for @entity3 , and day 25 after hospitalization for @entity1 ; risk of @entity2 declined 50% by day 11, 6, and 10, respectively. Daily change in risk of first readmission to hospital declined 95% by day 45, 38, and 45; daily change in risk of @entity2 declined 95% by day 21, 19, and 21. After hospitalization for @entity4 , @entity3 , or @entity1 , the magnitude of the relative risk for hospital admission over the first 90 days was 8, 6, and 6 times greater than that of the general older population; the relative risk of @entity2 was 11, 8, and 10 times greater. CONCLUSIONS: Risk declines slowly for older @entity0 after hospitalization for @entity4 , @entity3 , or @entity1 and is increased for months. Specific risk trajectories vary by discharge diagnosis and outcome. @entity0 should remain vigilant for deterioration in health for an extended time after discharge. Health providers can use knowledge of absolute risks and their changes over time to better align interventions designed to reduce adverse outcomes after discharge with the highest risk periods for @entity0 .

title: Trajectories of risk after hospitalization for XXXX , @entity3 , or @entity1 : retrospective cohort study.

answer: @entity4


abstract: OBJECTIVE: To characterize the absolute risks for older @entity0 of readmission to hospital and @entity2 in the year after hospitalization for @entity4 , @entity3 , or @entity1 . DESIGN: Retrospective cohort study. SETTING: 4767 hospitals caring for Medicare fee for service beneficiaries in the United States, 2008-10. @entity0 : More than 3 million Medicare fee for service beneficiaries, aged 65 years or more, surviving hospitalization for @entity4 , @entity3 , or @entity1 . MAIN OUTCOME MEASURES: Daily absolute risks of first readmission to hospital and @entity2 for one year after discharge. To illustrate risk trajectories, we identified the time required for risks of readmission to hospital and @entity2 to decline 50% from maximum values after discharge; the time required for risks to approach plateau periods of minimal day to day change, defined as 95% reductions in daily changes in risk from maximum daily declines after discharge; and the extent to which risks are higher among @entity0 recently discharged from hospital compared with the general elderly population. RESULTS: Within one year of hospital discharge, readmission to hospital and @entity2 , respectively, occurred following 67.4% and 35.8% of hospitalizations for @entity4 , 49.9% and 25.1% for @entity3 , and 55.6% and 31.1% for @entity1 . Risk of first readmission had declined 50% by day 38 after hospitalization for @entity4 , day 13 after hospitalization for @entity3 , and day 25 after hospitalization for @entity1 ; risk of @entity2 declined 50% by day 11, 6, and 10, respectively. Daily change in risk of first readmission to hospital declined 95% by day 45, 38, and 45; daily change in risk of @entity2 declined 95% by day 21, 19, and 21. After hospitalization for @entity4 , @entity3 , or @entity1 , the magnitude of the relative risk for hospital admission over the first 90 days was 8, 6, and 6 times greater than that of the general older population; the relative risk of @entity2 was 11, 8, and 10 times greater. CONCLUSIONS: Risk declines slowly for older @entity0 after hospitalization for @entity4 , @entity3 , or @entity1 and is increased for months. Specific risk trajectories vary by discharge diagnosis and outcome. @entity0 should remain vigilant for deterioration in health for an extended time after discharge. Health providers can use knowledge of absolute risks and their changes over time to better align interventions designed to reduce adverse outcomes after discharge with the highest risk periods for @entity0 .

title: Trajectories of risk after hospitalization for @entity4 , @entity3 , or XXXX : retrospective cohort study.

answer: @entity1


abstract: OBJECTIVE: To characterize the absolute risks for older @entity0 of readmission to hospital and @entity2 in the year after hospitalization for @entity4 , @entity3 , or @entity1 . DESIGN: Retrospective cohort study. SETTING: 4767 hospitals caring for Medicare fee for service beneficiaries in the United States, 2008-10. @entity0 : More than 3 million Medicare fee for service beneficiaries, aged 65 years or more, surviving hospitalization for @entity4 , @entity3 , or @entity1 . MAIN OUTCOME MEASURES: Daily absolute risks of first readmission to hospital and @entity2 for one year after discharge. To illustrate risk trajectories, we identified the time required for risks of readmission to hospital and @entity2 to decline 50% from maximum values after discharge; the time required for risks to approach plateau periods of minimal day to day change, defined as 95% reductions in daily changes in risk from maximum daily declines after discharge; and the extent to which risks are higher among @entity0 recently discharged from hospital compared with the general elderly population. RESULTS: Within one year of hospital discharge, readmission to hospital and @entity2 , respectively, occurred following 67.4% and 35.8% of hospitalizations for @entity4 , 49.9% and 25.1% for @entity3 , and 55.6% and 31.1% for @entity1 . Risk of first readmission had declined 50% by day 38 after hospitalization for @entity4 , day 13 after hospitalization for @entity3 , and day 25 after hospitalization for @entity1 ; risk of @entity2 declined 50% by day 11, 6, and 10, respectively. Daily change in risk of first readmission to hospital declined 95% by day 45, 38, and 45; daily change in risk of @entity2 declined 95% by day 21, 19, and 21. After hospitalization for @entity4 , @entity3 , or @entity1 , the magnitude of the relative risk for hospital admission over the first 90 days was 8, 6, and 6 times greater than that of the general older population; the relative risk of @entity2 was 11, 8, and 10 times greater. CONCLUSIONS: Risk declines slowly for older @entity0 after hospitalization for @entity4 , @entity3 , or @entity1 and is increased for months. Specific risk trajectories vary by discharge diagnosis and outcome. @entity0 should remain vigilant for deterioration in health for an extended time after discharge. Health providers can use knowledge of absolute risks and their changes over time to better align interventions designed to reduce adverse outcomes after discharge with the highest risk periods for @entity0 .

title: Trajectories of risk after hospitalization for @entity4 , XXXX , or @entity1 : retrospective cohort study.

answer: @entity3


abstract: AIM: This study compared the placental expression of the @entity1 ( @entity1 ) enzyme, which is thought to play a key role in the penetration of trophoblastic cells, in third-trimester @entity2 ( @entity2 ) @entity0 with that of @entity0 with normal pregnancies. METHODS: Twenty-five pregnant subjects who underwent cesarean section due to @entity2 and 25 term pregnant subjects who underwent cesarean section for obstetric reasons were included in the study. Demographic data, pathology reports, and histopathological samples were examined. Blocks containing samples of placenta underwent immunohistochemical analysis using the @entity1 antibody. Immunohistochemical expression of placental samples obtained from both groups was examined and compared. RESULTS: There were no statistically significant differences in the demographic data (P   >   0.05). With regard to immunohistochemistry, cytoplasmic staining of trophoblastic cells was considered immunohistochemically positive. In the @entity2 tissue samples, positive @entity1 staining was detected as follows: 0 immunoreactivity, one @entity0 (4%); 1(+), six @entity0 (24%); 2(+), seven @entity0 (28%); and 3(+), 11 @entity0 (44%). In the term pregnant placental tissue samples, positive @entity1 staining was detected in five @entity0 (20%) at 0 immunoreactivity, 12 (48%) at 1(+) immunoreactivity, five (20%) at 2(+) immunoreactivity, and three @entity0 (12%) at 3(+) immunoreactivity. Immunohistochemical expression was significantly different between the @entity2 and normal term pregnancy placental tissues (P   =   0.02). CONCLUSION: The stronger expression of the @entity1 enzyme in the @entity2 as compared to the normal placental tissue suggests that this enzyme may be an effective mediator in the pathogenesis of @entity2 .

title: What is the role of XXXX in @entity2 ?

answer: @entity1


abstract: AIM: This study compared the placental expression of the @entity1 ( @entity1 ) enzyme, which is thought to play a key role in the penetration of trophoblastic cells, in third-trimester @entity2 ( @entity2 ) @entity0 with that of @entity0 with normal pregnancies. METHODS: Twenty-five pregnant subjects who underwent cesarean section due to @entity2 and 25 term pregnant subjects who underwent cesarean section for obstetric reasons were included in the study. Demographic data, pathology reports, and histopathological samples were examined. Blocks containing samples of placenta underwent immunohistochemical analysis using the @entity1 antibody. Immunohistochemical expression of placental samples obtained from both groups was examined and compared. RESULTS: There were no statistically significant differences in the demographic data (P   >   0.05). With regard to immunohistochemistry, cytoplasmic staining of trophoblastic cells was considered immunohistochemically positive. In the @entity2 tissue samples, positive @entity1 staining was detected as follows: 0 immunoreactivity, one @entity0 (4%); 1(+), six @entity0 (24%); 2(+), seven @entity0 (28%); and 3(+), 11 @entity0 (44%). In the term pregnant placental tissue samples, positive @entity1 staining was detected in five @entity0 (20%) at 0 immunoreactivity, 12 (48%) at 1(+) immunoreactivity, five (20%) at 2(+) immunoreactivity, and three @entity0 (12%) at 3(+) immunoreactivity. Immunohistochemical expression was significantly different between the @entity2 and normal term pregnancy placental tissues (P   =   0.02). CONCLUSION: The stronger expression of the @entity1 enzyme in the @entity2 as compared to the normal placental tissue suggests that this enzyme may be an effective mediator in the pathogenesis of @entity2 .

title: What is the role of @entity1 in XXXX ?

answer: @entity2


abstract: UNASSIGNED: @entity0 is the main element of many pulp capping materials that are used to promote the regeneration of tertiary dentin, but the underlying molecular mechanism is not clear. In this study, we found that @entity0 increased the expression of the odontoblastic differentiation marker gene @entity8 and promoted odontoblastic differentiation and mineralization of DPSCs, but inhibited ALP activity. @entity0 increases the expression of endogenous @entity2 , which activates the @entity6 /8 pathway and promotes the @entity4 - @entity5 and @entity5 - @entity8 interaction in DPSCs. Inhibition of @entity6 /8 with @entity10 partially blocked @entity5 activity; however, inhibition of the @entity2 receptor with @entity9 nearly fully suppressed @entity5 activity. These results indicate that @entity0 promotes cell differentiation mainly via @entity2 -mediated Smad-dependent and Smad-independent pathways. We then determined that the phosphorylation level of @entity1 , but not JNK or @entity3 , was significantly increased as a result of @entity0 stimulation. Blockage of @entity1 was found to inhibit @entity5 activity, indicating that @entity0 triggers the @entity1 pathway, which subsequently regulates @entity5 activity. In addition, inhibition of @entity1 differentially attenuated the phosphorylation levels of @entity6 /8 and @entity7 . Collectively, this study demonstrates that @entity0 activates the @entity2 -mediated @entity6 /8 and @entity1 pathways in DPSCs and that @entity6 /8 and @entity1 signaling converge at @entity5 to control the odontoblastic differentiation of DPSCs. This article is protected by copyright. All rights reserved.

title: Extracellular @entity0 Promotes Odontoblastic Differentiation of Dental Pulp Stem Cells Via @entity2 -Mediated XXXX /8 and @entity1 Pathways.

answer: @entity6


abstract: UNASSIGNED: @entity0 is the main element of many pulp capping materials that are used to promote the regeneration of tertiary dentin, but the underlying molecular mechanism is not clear. In this study, we found that @entity0 increased the expression of the odontoblastic differentiation marker gene @entity8 and promoted odontoblastic differentiation and mineralization of DPSCs, but inhibited ALP activity. @entity0 increases the expression of endogenous @entity2 , which activates the @entity6 /8 pathway and promotes the @entity4 - @entity5 and @entity5 - @entity8 interaction in DPSCs. Inhibition of @entity6 /8 with @entity10 partially blocked @entity5 activity; however, inhibition of the @entity2 receptor with @entity9 nearly fully suppressed @entity5 activity. These results indicate that @entity0 promotes cell differentiation mainly via @entity2 -mediated Smad-dependent and Smad-independent pathways. We then determined that the phosphorylation level of @entity1 , but not JNK or @entity3 , was significantly increased as a result of @entity0 stimulation. Blockage of @entity1 was found to inhibit @entity5 activity, indicating that @entity0 triggers the @entity1 pathway, which subsequently regulates @entity5 activity. In addition, inhibition of @entity1 differentially attenuated the phosphorylation levels of @entity6 /8 and @entity7 . Collectively, this study demonstrates that @entity0 activates the @entity2 -mediated @entity6 /8 and @entity1 pathways in DPSCs and that @entity6 /8 and @entity1 signaling converge at @entity5 to control the odontoblastic differentiation of DPSCs. This article is protected by copyright. All rights reserved.

title: Extracellular XXXX Promotes Odontoblastic Differentiation of Dental Pulp Stem Cells Via @entity2 -Mediated @entity6 /8 and @entity1 Pathways.

answer: @entity0


abstract: UNASSIGNED: @entity0 is the main element of many pulp capping materials that are used to promote the regeneration of tertiary dentin, but the underlying molecular mechanism is not clear. In this study, we found that @entity0 increased the expression of the odontoblastic differentiation marker gene @entity8 and promoted odontoblastic differentiation and mineralization of DPSCs, but inhibited ALP activity. @entity0 increases the expression of endogenous @entity2 , which activates the @entity6 /8 pathway and promotes the @entity4 - @entity5 and @entity5 - @entity8 interaction in DPSCs. Inhibition of @entity6 /8 with @entity10 partially blocked @entity5 activity; however, inhibition of the @entity2 receptor with @entity9 nearly fully suppressed @entity5 activity. These results indicate that @entity0 promotes cell differentiation mainly via @entity2 -mediated Smad-dependent and Smad-independent pathways. We then determined that the phosphorylation level of @entity1 , but not JNK or @entity3 , was significantly increased as a result of @entity0 stimulation. Blockage of @entity1 was found to inhibit @entity5 activity, indicating that @entity0 triggers the @entity1 pathway, which subsequently regulates @entity5 activity. In addition, inhibition of @entity1 differentially attenuated the phosphorylation levels of @entity6 /8 and @entity7 . Collectively, this study demonstrates that @entity0 activates the @entity2 -mediated @entity6 /8 and @entity1 pathways in DPSCs and that @entity6 /8 and @entity1 signaling converge at @entity5 to control the odontoblastic differentiation of DPSCs. This article is protected by copyright. All rights reserved.

title: Extracellular @entity0 Promotes Odontoblastic Differentiation of Dental Pulp Stem Cells Via @entity2 -Mediated @entity6 /8 and XXXX Pathways.

answer: @entity1


abstract: UNASSIGNED: @entity0 is the main element of many pulp capping materials that are used to promote the regeneration of tertiary dentin, but the underlying molecular mechanism is not clear. In this study, we found that @entity0 increased the expression of the odontoblastic differentiation marker gene @entity8 and promoted odontoblastic differentiation and mineralization of DPSCs, but inhibited ALP activity. @entity0 increases the expression of endogenous @entity2 , which activates the @entity6 /8 pathway and promotes the @entity4 - @entity5 and @entity5 - @entity8 interaction in DPSCs. Inhibition of @entity6 /8 with @entity10 partially blocked @entity5 activity; however, inhibition of the @entity2 receptor with @entity9 nearly fully suppressed @entity5 activity. These results indicate that @entity0 promotes cell differentiation mainly via @entity2 -mediated Smad-dependent and Smad-independent pathways. We then determined that the phosphorylation level of @entity1 , but not JNK or @entity3 , was significantly increased as a result of @entity0 stimulation. Blockage of @entity1 was found to inhibit @entity5 activity, indicating that @entity0 triggers the @entity1 pathway, which subsequently regulates @entity5 activity. In addition, inhibition of @entity1 differentially attenuated the phosphorylation levels of @entity6 /8 and @entity7 . Collectively, this study demonstrates that @entity0 activates the @entity2 -mediated @entity6 /8 and @entity1 pathways in DPSCs and that @entity6 /8 and @entity1 signaling converge at @entity5 to control the odontoblastic differentiation of DPSCs. This article is protected by copyright. All rights reserved.

title: Extracellular @entity0 Promotes Odontoblastic Differentiation of Dental Pulp Stem Cells Via XXXX -Mediated @entity6 /8 and @entity1 Pathways.

answer: @entity2


abstract: INTRODUCTION: Despite surgical reattachment of retinal layers, postoperative functional outcomes after @entity1 ( @entity1 ) may be limited. This can be explained by microstructural changes in the macula inherent to the pathology itself as well as the surgery. PURPOSE: To evaluate the various changes in the macula by @entity2 pre- and postoperatively, and correlate them with functional and clinical outcomes in @entity0 with @entity1 . To establish pre- and postoperative prognostic factors. METHODS: This was a prospective study of 50 eyes of 50 @entity0 operated for RDD. Each @entity0 underwent a complete clinical examination and macular @entity2 using the Heidelberg Spectralis; preoperatively and then successively at 7 days, 1 month, 3 months and 6 months after @entity1 surgery. RESULTS: Preoperative tomographic results revealed an average height of submacular fluid of 742  345 m. Ninety-six percent of @entity0 exhibited thickening of photoreceptor outer segments (PROS), 62% an outer layer undulation, 60% cystic cavities in the outer and/or inner nuclear layers (ONL, INL), 36% disruptions of the external limiting membrane (ELM) and 64% disruption of the IS/OS junction. Postoperatively, 24% of @entity0 had persistent submacular fluid. The average thickness of the central fovea, the ONL, the IS/OS junction and the PROS were 172  51.3 m, 88.4  30.9 m, 11.36  5.4 m and 19.54  13.1 m respectively. Postoperative disruptions of the ELM, the IS/OS junction and Verhoeff's membrane (VM) were present in 24%, 60% and 82% of @entity0 respectively. The preoperative tomographic risk factors for poor visual outcome were: submacular fluid height>800 m (P<0.001), disruptions of the MLE and/or IS/OS junction (P<0.001), as well as cystic cavities in the @entity3 and/or INL (P=0.002). Postoperative risk factors were: thinning of the fovea ( <=250 m), central fovea ( <=160 m), ONL ( <=90 m), IS/OS junction ( <= 10 m) and PROS ( <=18 m) layers (P<0.001), as well as a discontinuous or absent appearance of the ELM (P<0.001), IS/OS junction (P<0.001) and VM (P=0.006). CONCLUSION: Spectral domain @entity2 allows detection of specific microscopic, quasi-histologic macular changes in @entity1 . These anomalies could be predictive of final postoperative visual outcome.

title: [Macula analysis by spectral domain XXXX in @entity1 surgery.]

answer: @entity2


abstract: INTRODUCTION: Despite surgical reattachment of retinal layers, postoperative functional outcomes after @entity1 ( @entity1 ) may be limited. This can be explained by microstructural changes in the macula inherent to the pathology itself as well as the surgery. PURPOSE: To evaluate the various changes in the macula by @entity2 pre- and postoperatively, and correlate them with functional and clinical outcomes in @entity0 with @entity1 . To establish pre- and postoperative prognostic factors. METHODS: This was a prospective study of 50 eyes of 50 @entity0 operated for RDD. Each @entity0 underwent a complete clinical examination and macular @entity2 using the Heidelberg Spectralis; preoperatively and then successively at 7 days, 1 month, 3 months and 6 months after @entity1 surgery. RESULTS: Preoperative tomographic results revealed an average height of submacular fluid of 742  345 m. Ninety-six percent of @entity0 exhibited thickening of photoreceptor outer segments (PROS), 62% an outer layer undulation, 60% cystic cavities in the outer and/or inner nuclear layers (ONL, INL), 36% disruptions of the external limiting membrane (ELM) and 64% disruption of the IS/OS junction. Postoperatively, 24% of @entity0 had persistent submacular fluid. The average thickness of the central fovea, the ONL, the IS/OS junction and the PROS were 172  51.3 m, 88.4  30.9 m, 11.36  5.4 m and 19.54  13.1 m respectively. Postoperative disruptions of the ELM, the IS/OS junction and Verhoeff's membrane (VM) were present in 24%, 60% and 82% of @entity0 respectively. The preoperative tomographic risk factors for poor visual outcome were: submacular fluid height>800 m (P<0.001), disruptions of the MLE and/or IS/OS junction (P<0.001), as well as cystic cavities in the @entity3 and/or INL (P=0.002). Postoperative risk factors were: thinning of the fovea ( <=250 m), central fovea ( <=160 m), ONL ( <=90 m), IS/OS junction ( <= 10 m) and PROS ( <=18 m) layers (P<0.001), as well as a discontinuous or absent appearance of the ELM (P<0.001), IS/OS junction (P<0.001) and VM (P=0.006). CONCLUSION: Spectral domain @entity2 allows detection of specific microscopic, quasi-histologic macular changes in @entity1 . These anomalies could be predictive of final postoperative visual outcome.

title: [Macula analysis by spectral domain @entity2 in XXXX surgery.]

answer: @entity1


abstract: In @entity6 , the oral and subcutaneous LD50 values were very similar (cf. 0,173 mg/kg over 48 h with 0,116 mg/kg over 24 and 48 h). When dosed subcutaneously, a cumulative effect was observed. Intravenous administration of @entity13 to anaesthetized @entity6 resulted in: dyspnoea, @entity0 , and electrocardiagraphic changes typical of @entity1 . A positive cardiac inotropic effect was succeeded by a positive chronotropic one. In @entity5 , acute and subacute intoxication resulted in ruminal, respiratory and cardiac changes. The signs included @entity11 , @entity7 , @entity8 , @entity12 , followed by @entity3 and progressive respiratory and @entity4 . The skeletal muscles were affected in only 1 @entity5 vide infra. In chronically intoxicated @entity5 typical clinical signs of "krimpsiekte" developed, e.g. weakness, reluctance to stand, unsteadiness on feet, @entity2 and paresis of hindquarter muscles, paresis of the neck, arching of the back and standing with the feet close together. Respiratory function was affected in all 3 cases; @entity11 , with concomitant @entity10 occurring in one, and a transient change in heart function in another. The syndrome induced by acute @entity13 poisoning is similar to that of other cardiac glycosides, but the paretic signs of @entity9 resemble "krimpsiekte", a disease associated only with intoxication with the plants of the family Crassulaceae.

title: Studies on South African cardiac glycosides. II. Observations on the clinical and haemodynamic effects of XXXX .

answer: @entity13


abstract: The causes of @entity4 and immunosuppression, major outcomes of @entity3 , are not well established. This study was undertaken to investigate whether @entity7 ( @entity7 ) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of @entity1 . Groups of female Balb/c @entity0 infected with @entity8 vinckei vinckei, @entity5 , or @entity8 adami were exposed to five hours of simulated altitude equivalent to 22,000 ft. Plasma samples were collected for @entity7 bioassay and radioimmunoassay (RIA). Using radioiron incorporation as an index of erythropoiesis, differences in response to @entity1 with different species of plasmodia were observed. In general, decreases in erythropoietic activity were observed in bone marrow and spleen as the @entity1 progressed and continued to be @entity2 after apparent resolution of a nonlethal @entity1 with @entity8 adami. Marrow from infected and control femurs were tested for CFU-S content using the spleen colony assay. The cellularity and CFU-S content of the femoral marrow decrease as the @entity6 increases. All three species of plasmodia stimulate @entity7 production during peak @entity6 , indicating that adequate amounts of @entity7 are available to the erythron during @entity1 . Depletion of CFU-S and probable lack of compensatory turnover of CFU-S may contribute to the disease characteristics of @entity3 .

title: @entity0 XXXX decreases hemopoietic stem cells.

answer: @entity3


abstract: The causes of @entity4 and immunosuppression, major outcomes of @entity3 , are not well established. This study was undertaken to investigate whether @entity7 ( @entity7 ) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of @entity1 . Groups of female Balb/c @entity0 infected with @entity8 vinckei vinckei, @entity5 , or @entity8 adami were exposed to five hours of simulated altitude equivalent to 22,000 ft. Plasma samples were collected for @entity7 bioassay and radioimmunoassay (RIA). Using radioiron incorporation as an index of erythropoiesis, differences in response to @entity1 with different species of plasmodia were observed. In general, decreases in erythropoietic activity were observed in bone marrow and spleen as the @entity1 progressed and continued to be @entity2 after apparent resolution of a nonlethal @entity1 with @entity8 adami. Marrow from infected and control femurs were tested for CFU-S content using the spleen colony assay. The cellularity and CFU-S content of the femoral marrow decrease as the @entity6 increases. All three species of plasmodia stimulate @entity7 production during peak @entity6 , indicating that adequate amounts of @entity7 are available to the erythron during @entity1 . Depletion of CFU-S and probable lack of compensatory turnover of CFU-S may contribute to the disease characteristics of @entity3 .

title: XXXX @entity3 decreases hemopoietic stem cells.

answer: @entity0


abstract: INTRODUCTION: First experiences with laparoscopic low anterior resection with transanal mesorectal excision in @entity0 with low and mid @entity1 are referred. METHODS: During a 9 month period (between October 2013 and May 2014), 17 laparoscopically assisted rectal resections with transanal total mesorectal excision, hand-sewn colo-anal @entity3 and protective ileostomy were performed at two institutions (CHK FN Brno, CHO KOC Nov   Ji    n). There were 11 males and 6 females, with a mean age 68 years (range 49-81 years) in our cohort. The @entity1 was located 30-80mm from the anal verge (median 60 mm). RESULTS: A negative distal resection margin was achieved in all @entity0 . The circumferential resection margin was positive in two cases. The TME quality was described as complete in 8 cases and nearly complete in 9 cases. Mean operative time was 280 min (range 212-375 min) with no intra-operative complications. @entity5 was observed in two @entity0 (12%). Median length of postoperative hospital stay was 9 days with a range of 6-30 days, in case of @entity4 . CONCLUSION: According to our first experience we evaluated this method as feasible and safe with satisfactory pathological outcomes. We cannot recommend exact indications yet. It is assumed that the transanal approach for total mesorectal excision should be indicated in @entity2 @entity0 with a narrow pelvis and voluminous prostate.Key words: total mesorectal excision transanal minimally invasive surgery.

title: [Transanal total mesorectal excision for XXXX - first results].

answer: @entity1


abstract: BACKGROUND: Transanal @entity3 , although it showed reliability, has not completely removed the issue of @entity2 . OBJECTIVE: We investigated the causes of @entity2 and proposed some changes of the technique in order to eliminate it. @entity0 : One hundred six out of 188 operated @entity0 were considered. @entity2 was investigated using a Visual Analogue Score dividing @entity0 into three groups: 0 to 3, 4 to 6, and 7 to 10. On the basis of these results, we proposed some variations of the technique. A second group of 25 @entity0 was therefore treated with the modified technique. Statistical analysis was conducted using the Fisher's exact test, two-tailed. MAIN OUTCOME: @entity1 intensity, surgical approach, and changes in the technique were analyzed, and a new proposal for a modified technique has been developed. RESULTS: The group of 106 @entity0 , 64 males and 42 females, were divided: 71 III grade and 35 IV grade. @entity1 was detected in 37 cases (35  %).Fifteen males (23.50  %) were divided as follows: 8 mild and 7 medium or intense. Twenty-two females (52.38  %) were divided as follows: 11 mild and 11 with medium or intense. For what concerns the variable grade, the @entity1 was present in 15 III G and 22 IV G with statistic significant difference (p value 0.00333). Among the 18 @entity0 (7 males and 11 females) who had severe @entity1 , they all had a number of mucopexies >4, while among 19 @entity0 (8 males and 11 females) with mild @entity1 , only 5 had a number of mucopexies >4, resulting in a statistic significant difference (p value 0.031). In the second group, @entity1 was drastically reduced. LIMITATIONS: We believe it is necessary to extend the sample in order to definitively adopt the proposed amendments. CONCLUSIONS: The review of the causes of @entity2 and the changes adopted compared with those proposed in literature have allowed us to greatly reduce @entity2 .

title: Doppler-guided hemorrhoidal artery ligation with hemorrhoidopexy: source and prevention of XXXX .

answer: @entity2