abstract: Glucose and amino acids are key nutrients supporting cell growth. Amino acids are imported as monomers, but an alternative route induced by oncogenic @entity3 involves uptake of extracellular proteins via macropinocytosis and subsequent lysosomal degradation of these proteins as a source of amino acids. In this study, we examined the metabolism of @entity4 ( @entity4 ), a poorly vascularized lethal @entity3 -driven malignancy. Metabolomic comparisons of @entity0 @entity4 and benign adjacent tissue revealed that @entity1 tissue was low in glucose, upper glycolytic intermediates, creatine phosphate, and the amino acids glutamine and serine, two major metabolic substrates. Surprisingly, @entity4 accumulated essential amino acids. Such accumulation could arise from extracellular proteins being degraded through macropinocytosis in quantities necessary to meet glutamine requirements, which in turn produces excess of most other amino acids. Consistent with this hypothesis, active macropinocytosis is observed in primary @entity0 @entity4 specimens. Moreover, in the presence of physiologic albumin, we found that cultured @entity2 @entity4 cells grow indefinitely in media lacking single essential amino acids and replicate once in the absence of free amino acids. Growth under these conditions was characterized by simultaneous glutamine depletion and essential amino acid accumulation. Overall, our findings argue that the scavenging of extracellular proteins is an important mode of nutrient uptake in @entity4 . @entity1 Res; 75(3); 544-53.   2014 AACR.

title: @entity0 pancreatic cancer tumors are nutrient poor and XXXX cells actively scavenge extracellular protein.

answer: @entity1


abstract: Glucose and amino acids are key nutrients supporting cell growth. Amino acids are imported as monomers, but an alternative route induced by oncogenic @entity3 involves uptake of extracellular proteins via macropinocytosis and subsequent lysosomal degradation of these proteins as a source of amino acids. In this study, we examined the metabolism of @entity4 ( @entity4 ), a poorly vascularized lethal @entity3 -driven malignancy. Metabolomic comparisons of @entity0 @entity4 and benign adjacent tissue revealed that @entity1 tissue was low in glucose, upper glycolytic intermediates, creatine phosphate, and the amino acids glutamine and serine, two major metabolic substrates. Surprisingly, @entity4 accumulated essential amino acids. Such accumulation could arise from extracellular proteins being degraded through macropinocytosis in quantities necessary to meet glutamine requirements, which in turn produces excess of most other amino acids. Consistent with this hypothesis, active macropinocytosis is observed in primary @entity0 @entity4 specimens. Moreover, in the presence of physiologic albumin, we found that cultured @entity2 @entity4 cells grow indefinitely in media lacking single essential amino acids and replicate once in the absence of free amino acids. Growth under these conditions was characterized by simultaneous glutamine depletion and essential amino acid accumulation. Overall, our findings argue that the scavenging of extracellular proteins is an important mode of nutrient uptake in @entity4 . @entity1 Res; 75(3); 544-53.   2014 AACR.

title: XXXX pancreatic cancer tumors are nutrient poor and @entity1 cells actively scavenge extracellular protein.

answer: @entity0


abstract: PURPOSE: To analyze the incidence and mortality of @entity2 in the @entity0 registration areas of China in 2010. MATERIALS AND METHODS: Until June 1, 2013, 219 population-based @entity0 registries submitted the data of 2010 to the National Central @entity0 Registry of China covering about 207,229,403 population, and 120 @entity0 registries were selected after the quality evaluation for this analysis. @entity2 cases were selected from the database according to the International Classification of Diseases-10 coded as "C00-C10, C11-C12." We calculated the crude incidence and mortality rates of @entity2 by sex, age, and location (urban/rural). The China population in 2000 and Segi's population were used as standardized populations for the calculation of age standardized rates. RESULTS: In 2010, it was estimated that there were 34,319 new cases diagnosed as @entity2 in China, including 23,096 males and 11,223 females. The crude incidence rate of @entity2 was 2.61/100,000 in 2010, accounting for 1.11% of overall new @entity0 cases, ranked the 20th in all @entity0 sites. The age standardized by China population (ASRcn) and by world population (ASRwld) were 2.06/100,000 and 2.02/100,000, respectively. Cumulative rate (0-74 years old) and truncated age standardized rate (35-64 years old) were 0.23% and 3.82/100 000, respectively. In 2010, it was estimated that there were 14,652 cases died in @entity2 in China, including 10,363 males and 4289 females. The crude mortality rate of @entity2 was 1.11/100,000 in 2010, accounting for 0.75% of overall @entity0 deaths, ranked the 20th in all @entity0 sites. The ASRcn and ASRwld were 0.86/100,000 and 0.85/100,000, respectively. Cumulative rate and truncated age standardized rates were 0.10% and 1.30/100,000, respectively. CONCLUSIONS: Both the incidence and mortality of @entity2 in China were still low in 2010. Primary prevention such as smoking control, reducing @entity1 consumption, changing the habit of chewing betel nut, and chemical prevention should be enhanced in the general population.

title: XXXX incidence and mortality in China, 2010.

answer: @entity2


abstract: BACKGROUND/AIM: There is scarce literature connecting @entity8 and @entity5 ( @entity5 ). Most literature reports that secondary complications are a direct consequence of corticosteroid treatment of @entity8 . In this study, we aimed to investigate the prevalence of @entity9 in @entity0 with @entity8 and to determine its association with periorbital topical @entity1 use. METHOD: A cross-sectional study was carried out on 90 @entity0 with @entity8 . The Vitiligo European Task Force questionnaire was completed for each @entity0 . A control group comprising 90 healthy individuals who did not have @entity8 and who were matched on age and gender was used for comparison. A complete ophthalmologic examination was performed. A family history of @entity6 and the use of topical @entity2 were recorded. RESULTS: Two (2/90, 2.2%) of the @entity0 with @entity8 had @entity6 compared with none of the individuals in the control group (P = .25). Nineteen of the 90 @entity0 with @entity8 used periorbital @entity2 , and of these @entity0 , 10.5% (2/19) developed @entity6 . The duration of periorbital corticosteroid use was 4.50    2.1 years. Eighty-nine percent (17/19) of the @entity8 @entity0 who applied the potent topical corticosteroid (class I) @entity10 to the periorbital area did not develop @entity6 . In contrast, @entity6 was not observed in 79% (71/90) of the @entity8 @entity0 who did not use @entity2 . @entity3 , @entity7 , or fundus problems were not observed in either group. CONCLUSION: The study suggests that @entity0 who have @entity8 and use topical @entity2 periorbitally do not have an increased risk of @entity6 or @entity3 . Future studies that have a larger sample size and use a detailed @entity4 use protocol are needed.

title: Screening of XXXX or @entity3 Prevalence in Vitiligo @entity0 and Its Relationship With Periorbital Steroid Use.

answer: @entity6


abstract: BACKGROUND/AIM: There is scarce literature connecting @entity8 and @entity5 ( @entity5 ). Most literature reports that secondary complications are a direct consequence of corticosteroid treatment of @entity8 . In this study, we aimed to investigate the prevalence of @entity9 in @entity0 with @entity8 and to determine its association with periorbital topical @entity1 use. METHOD: A cross-sectional study was carried out on 90 @entity0 with @entity8 . The Vitiligo European Task Force questionnaire was completed for each @entity0 . A control group comprising 90 healthy individuals who did not have @entity8 and who were matched on age and gender was used for comparison. A complete ophthalmologic examination was performed. A family history of @entity6 and the use of topical @entity2 were recorded. RESULTS: Two (2/90, 2.2%) of the @entity0 with @entity8 had @entity6 compared with none of the individuals in the control group (P = .25). Nineteen of the 90 @entity0 with @entity8 used periorbital @entity2 , and of these @entity0 , 10.5% (2/19) developed @entity6 . The duration of periorbital corticosteroid use was 4.50    2.1 years. Eighty-nine percent (17/19) of the @entity8 @entity0 who applied the potent topical corticosteroid (class I) @entity10 to the periorbital area did not develop @entity6 . In contrast, @entity6 was not observed in 79% (71/90) of the @entity8 @entity0 who did not use @entity2 . @entity3 , @entity7 , or fundus problems were not observed in either group. CONCLUSION: The study suggests that @entity0 who have @entity8 and use topical @entity2 periorbitally do not have an increased risk of @entity6 or @entity3 . Future studies that have a larger sample size and use a detailed @entity4 use protocol are needed.

title: Screening of @entity6 or XXXX Prevalence in Vitiligo @entity0 and Its Relationship With Periorbital Steroid Use.

answer: @entity3


abstract: BACKGROUND/AIM: There is scarce literature connecting @entity8 and @entity5 ( @entity5 ). Most literature reports that secondary complications are a direct consequence of corticosteroid treatment of @entity8 . In this study, we aimed to investigate the prevalence of @entity9 in @entity0 with @entity8 and to determine its association with periorbital topical @entity1 use. METHOD: A cross-sectional study was carried out on 90 @entity0 with @entity8 . The Vitiligo European Task Force questionnaire was completed for each @entity0 . A control group comprising 90 healthy individuals who did not have @entity8 and who were matched on age and gender was used for comparison. A complete ophthalmologic examination was performed. A family history of @entity6 and the use of topical @entity2 were recorded. RESULTS: Two (2/90, 2.2%) of the @entity0 with @entity8 had @entity6 compared with none of the individuals in the control group (P = .25). Nineteen of the 90 @entity0 with @entity8 used periorbital @entity2 , and of these @entity0 , 10.5% (2/19) developed @entity6 . The duration of periorbital corticosteroid use was 4.50    2.1 years. Eighty-nine percent (17/19) of the @entity8 @entity0 who applied the potent topical corticosteroid (class I) @entity10 to the periorbital area did not develop @entity6 . In contrast, @entity6 was not observed in 79% (71/90) of the @entity8 @entity0 who did not use @entity2 . @entity3 , @entity7 , or fundus problems were not observed in either group. CONCLUSION: The study suggests that @entity0 who have @entity8 and use topical @entity2 periorbitally do not have an increased risk of @entity6 or @entity3 . Future studies that have a larger sample size and use a detailed @entity4 use protocol are needed.

title: Screening of @entity6 or @entity3 Prevalence in Vitiligo XXXX and Its Relationship With Periorbital Steroid Use.

answer: @entity0


abstract: An experiment was conducted to compare the effect of a supplementary mixture of essential oils, with and without exogenous xylanase, on performance, carcass composition, dietary @entity1 (N)-corrected apparent metabolizable energy (AMEn), dry matter retention (DMR), N retention (NR), @entity0 ( @entity0 ) coefficients, and endogenous @entity7 losses (measured as @entity3 , SA) when fed to broiler @entity2 . Three hundred male Ross 308 broilers in total were reared in floor pens from 0 to 21 d of age. Birds were fed 1 of 3 @entity4 -based diets: basal diet (215 g/kg CP, 12.12 MJ/kg AME) with either no additive (control diet; C) or 100 g/tonne of a standardized combination of 5% @entity5 , 3% @entity6 , and 2% capsicum oleoresin (diet XT); or a combination of XT and commercial xylanase enzyme at a rate of 100 g of XT and 2,000 units (U) of xylanase/kg (diet XYL), respectively. Each diet was randomly allocated to 10 pens with 10 birds. Feeding XT and XYL diets improved birds' growth performance (P<0.05). Birds fed XT and XYL diets had an improved caloric conversion ratio (P<0.05) and consumed 1.3 MJ less AMEn per kilogram of growth compared to birds fed the control diet only. Feeding XT improved only the dietary @entity0 coefficient (P<0.05) compared to control-fed birds, but the dietary @entity0 coefficient did not differ for XYL diet (P>0.05). Birds fed XYL diet excreted 35% less endogenous @entity7 compared to control-fed birds (P<0.05). Birds fed XT alone gained more carcass protein than the control-fed birds (P<0.05) but did not differ from the birds fed XYL diet (P>0.05). There was no indication of a negative interaction between dietary essential oils and xylanase.

title: Growth performance and endogenous losses of broilers fed XXXX -based diets with and without essential oils and xylanase supplementation.

answer: @entity4


abstract: UNASSIGNED: @entity1 cells within a @entity1 are functionally heterogeneous and specific subpopulations, defined as @entity1 initiating cells (CICs), are endowed with higher @entity1 forming potential. The CIC state, however, is not hierarchically stable and conversion of non-CICs to CICs under microenvironment signals might represent a determinant of @entity2 . How plasticity is regulated at the cellular level is however poorly understood. To identify determinants of plasticity in @entity0 we exposed eight different cell lines to @entity3 to induce EMT and stimulate modulation of CD133(+)  CICs. We show that response to @entity3 treatment is heterogeneous with some cells readily switching to stem cell state (1.5-2 fold CICs increase) and others being unresponsive to stimulation. This response is unrelated to original CICs content or extent of EMT engagement but is tightly dependent on balance between epithelial and mesenchymal features as measured by the ratio of expression of @entity4 ( @entity4 ) to @entity5 . Epigenetic modulation of this balance can restore sensitivity of unresponsive models to microenvironmental stimuli, including those elicited by @entity1 -associated fibroblasts both in  vitro and in  vivo. In particular, @entity1 with increased prevalence of cells with features of partial EMT (hybrid epithelial/mesenchymal phenotype) are endowed with the highest plasticity and specific patterns of expression of @entity5 and @entity4 markers identify a subset of @entity1 with worse prognosis. In conclusion, here we describe a connection between a hybrid epithelial/mesenchymal phenotype and conversion to stem-cell state in response to external stimuli. These findings have implications for current endeavors to identify @entity1 with increased plasticity.

title: Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in XXXX cells.

answer: @entity0


abstract: BACKGROUND: - @entity5 @entity4 is a @entity0 missense Long QT2 mutation. Previously we reported that the @entity5 / @entity5 mutation embryos disrupted cardiac looping; right ventricle development; and ablated IKr activity at E9.5. The present study evaluates the role of @entity4 in vasculogenesis. METHODS AND RESULTS: - @entity5 / @entity5 yolk sac vessels and aorta consist of sinusoids without normal arborization. Isolated E9.5 +/+ first branchial arches showed normal outgrowth of mERG-positive / @entity1 co-immunolocalized cells; however outgrowth was grossly reduced in @entity5 / @entity5 . @entity5 / @entity5 aortas showed fewer @entity1 positive cells which were not co-immunolocalized with mERG cells. @entity2 treatment of isolated @entity5 / @entity5 embryoid bodies partially rescued this phenotype. Cultured @entity5 / @entity5 embryos recapitulate the same cardiovascular phenotypes as seen in vivo. @entity2 treatment significantly rescued these embryonic phenotypes. Both in vivo and in vitro, dofetilide treatment, over a narrow window of time, entirely recapitulated the @entity5 / @entity5 fetal phenotypes. Exogenous @entity2 treatment also rescued the dofetilide-induced phenotype towards normal. CONCLUSIONS: -Loss of function of @entity3 results in defects in cardiogenesis and vasculogenesis. Since many medications inadvertently block the @entity3 potassium current ( @entity4 ), these novel findings appear to have clinical relevance.

title: Role of Mutation and Pharmacologic Block of XXXX ( @entity4 ) in Vasculogenesis and Fetal Mortality: Partial Rescue by @entity2

answer: @entity3


abstract: BACKGROUND: - @entity5 @entity4 is a @entity0 missense Long QT2 mutation. Previously we reported that the @entity5 / @entity5 mutation embryos disrupted cardiac looping; right ventricle development; and ablated IKr activity at E9.5. The present study evaluates the role of @entity4 in vasculogenesis. METHODS AND RESULTS: - @entity5 / @entity5 yolk sac vessels and aorta consist of sinusoids without normal arborization. Isolated E9.5 +/+ first branchial arches showed normal outgrowth of mERG-positive / @entity1 co-immunolocalized cells; however outgrowth was grossly reduced in @entity5 / @entity5 . @entity5 / @entity5 aortas showed fewer @entity1 positive cells which were not co-immunolocalized with mERG cells. @entity2 treatment of isolated @entity5 / @entity5 embryoid bodies partially rescued this phenotype. Cultured @entity5 / @entity5 embryos recapitulate the same cardiovascular phenotypes as seen in vivo. @entity2 treatment significantly rescued these embryonic phenotypes. Both in vivo and in vitro, dofetilide treatment, over a narrow window of time, entirely recapitulated the @entity5 / @entity5 fetal phenotypes. Exogenous @entity2 treatment also rescued the dofetilide-induced phenotype towards normal. CONCLUSIONS: -Loss of function of @entity3 results in defects in cardiogenesis and vasculogenesis. Since many medications inadvertently block the @entity3 potassium current ( @entity4 ), these novel findings appear to have clinical relevance.

title: Role of Mutation and Pharmacologic Block of @entity3 ( @entity4 ) in Vasculogenesis and Fetal Mortality: Partial Rescue by XXXX

answer: @entity2


abstract: BACKGROUND: - @entity5 @entity4 is a @entity0 missense Long QT2 mutation. Previously we reported that the @entity5 / @entity5 mutation embryos disrupted cardiac looping; right ventricle development; and ablated IKr activity at E9.5. The present study evaluates the role of @entity4 in vasculogenesis. METHODS AND RESULTS: - @entity5 / @entity5 yolk sac vessels and aorta consist of sinusoids without normal arborization. Isolated E9.5 +/+ first branchial arches showed normal outgrowth of mERG-positive / @entity1 co-immunolocalized cells; however outgrowth was grossly reduced in @entity5 / @entity5 . @entity5 / @entity5 aortas showed fewer @entity1 positive cells which were not co-immunolocalized with mERG cells. @entity2 treatment of isolated @entity5 / @entity5 embryoid bodies partially rescued this phenotype. Cultured @entity5 / @entity5 embryos recapitulate the same cardiovascular phenotypes as seen in vivo. @entity2 treatment significantly rescued these embryonic phenotypes. Both in vivo and in vitro, dofetilide treatment, over a narrow window of time, entirely recapitulated the @entity5 / @entity5 fetal phenotypes. Exogenous @entity2 treatment also rescued the dofetilide-induced phenotype towards normal. CONCLUSIONS: -Loss of function of @entity3 results in defects in cardiogenesis and vasculogenesis. Since many medications inadvertently block the @entity3 potassium current ( @entity4 ), these novel findings appear to have clinical relevance.

title: Role of Mutation and Pharmacologic Block of @entity3 ( XXXX ) in Vasculogenesis and Fetal Mortality: Partial Rescue by @entity2

answer: @entity4


abstract: OBJECTIVES: To assess @entity3 after off-pump coronary-artery bypass grafting, with a particular emphasis on long-term follow-up and related risk factors. DESIGN: Prospective study. SETTING: Virgen de la Victoria University Hospital, M  laga, Spain. @entity0 : @entity0 were 36 @entity0 undergoing off-pump coronary-artery bypass grafting. MEASUREMENTS: Changes in the neuropsychological test battery administered from before to after surgery (1, 6, and 12  months). Postoperative @entity3 was defined by a significant decrease. RESULTS: A significantly multidomain (attention-executive functions, P  <  .01; immediate and delayed memory, P  <  .001; and verbal fluency, P  <  .05) postoperative @entity3 was shown, being maximum at 6  months (more than 50% of @entity0 ) and still presented at 12  months (more than 30% of @entity0 ), but partially recovered. Related risk factors as smoking (P  <  .01), @entity1 (P  <  .01), peripheral @entity5 (P  <  .01), @entity2 (P  <  .05), lower hematocrit (P  <  .01), and hemoglobin (P  <  .05) levels and diastolic blood pressure (P  <  .05) were identified as predictors of @entity3 . Better New York Heart Association class (P  <  .01) and less severity of @entity4 (P  <  .01) were associated with partial postoperative recovering. CONCLUSION: A multidomain long-term postoperative @entity3 and a partial neurocognitive recovering were detected after off-pump coronary-artery bypass grafting and were associated with several nonspecific surgery factors. These findings may be useful when counseling @entity0 before surgery and suggest the importance of long-term neurocognitive evaluation.

title: Assessment of Long-Term XXXX After Off-Pump Coronary-Artery Bypass Grafting and Related Risk Factors.

answer: @entity3


abstract: BACKGROUND: @entity3 toxins A and B (TcdA and TcdB), considered to be essential for @entity3 infection, affect the morphology of several cell types with different potencies and timing. However, morphological changes over various time scales are poorly characterized. The toxins' glucosyltransferase domains are critical to their deleterious effects, and cell responses to glucosyltransferase-independent activities are incompletely understood. By tracking morphological changes of multiple cell types to @entity3 toxins with high temporal resolution, cellular responses to TcdA, TcdB, and @entity4 TcdB (gdTcdB) are elucidated. RESULTS: @entity0 umbilical vein endothelial cells, @entity1 macrophage-like cells, and four epithelial cell lines (HCT8, T84, @entity2 , and immortalized @entity1 cecal epithelial cells) were treated with TcdA, TcdB, gdTcdB. Impedance across cell cultures was measured to track changes in cell morphology. Metrics from impedance data, developed to quantify rapid and long-lasting responses, produced standard curves with wide dynamic ranges that defined cell line sensitivities. Except for T84 cells, all cell lines were most sensitive to TcdB. J774 macrophages stretched and increased in size in response to TcdA and TcdB but not gdTcdB. High concentrations of TcdB and gdTcdB (>10  ng/ml) greatly reduced macrophage viability. In HCT8 cells, gdTcdB did not induce a rapid cytopathic effect, yet it delayed TcdA and TcdB's rapid effects. gdTcdB did not clearly delay TcdA or TcdB's toxin-induced effects on macrophages. CONCLUSIONS: Epithelial and endothelial cells have similar responses to toxins yet differ in timing and degree. Relative potencies of TcdA and TcdB in @entity1 epithelial cells in vitro do not correlate with potencies in vivo. TcdB requires glucosyltransferase activity to cause macrophages to spread, but cell death from high TcdB concentrations is glucosyltransferase-independent. Competition experiments with gdTcdB in epithelial cells confirm common TcdA and TcdB mechanisms, yet different responses of macrophages to TcdA and TcdB suggest different, additional mechanisms or targets in these cells. This first-time, precise quantification of the response of multiple cell lines to TcdA and TcdB provides a comparative framework for delineating the roles of different cell types and toxin-host interactions.

title: High temporal resolution of glucosyltransferase dependent and independent effects of XXXX toxins across multiple cell types.

answer: @entity3


abstract: AIMS: @entity1 is a rare, malignant @entity0 originating from the periosteal surface of bone. We collected 38 cases from the archives of the Netherlands Committee on Bone Tumours, with the aim of studying histological features and evaluating the involvement of @entity2 ( @entity2 ), EXT, Wnt/b-catenin, the @entity5 pathway ( @entity7 and @entity4 ), and the @entity3 pathway ( @entity3 and @entity6 ). METHODS AND RESULTS: Histology showed a moderately cellular matrix with mucoid-myxoid changes and, in 42% of cases, formation of a neocortex. Occasional intramedullary extension (26%) and subsequent host bone entrapment (40%) were seen. Histological grading revealed grade 1 (53%) and grade 2 (45%). The @entity8 protein was normally expressed, and mutations in @entity2 were observed in only 15% of cases. @entity5 signalling was deregulated by loss of @entity4 expression in 50% of cases, and Wnt signalling was lost in 89%. No alterations were found in @entity7 , @entity3 , or @entity6 . CONCLUSIONS: We report the first large histological and molecular study on @entity1 showing that histopathological examination and molecular aberrations do not predict prognosis. Although the mutation frequency of @entity2 was low, we confirm the supposed relationship with central @entity1 . Moreover, we identify loss of canonical Wnt signalling and deregulation of @entity5 signalling as possible events contributing to its histogenesis.

title: XXXX : a histopathological and molecular analysis of a rare @entity1 subtype.

answer: @entity1


abstract: AIMS: @entity1 is a rare, malignant @entity0 originating from the periosteal surface of bone. We collected 38 cases from the archives of the Netherlands Committee on Bone Tumours, with the aim of studying histological features and evaluating the involvement of @entity2 ( @entity2 ), EXT, Wnt/b-catenin, the @entity5 pathway ( @entity7 and @entity4 ), and the @entity3 pathway ( @entity3 and @entity6 ). METHODS AND RESULTS: Histology showed a moderately cellular matrix with mucoid-myxoid changes and, in 42% of cases, formation of a neocortex. Occasional intramedullary extension (26%) and subsequent host bone entrapment (40%) were seen. Histological grading revealed grade 1 (53%) and grade 2 (45%). The @entity8 protein was normally expressed, and mutations in @entity2 were observed in only 15% of cases. @entity5 signalling was deregulated by loss of @entity4 expression in 50% of cases, and Wnt signalling was lost in 89%. No alterations were found in @entity7 , @entity3 , or @entity6 . CONCLUSIONS: We report the first large histological and molecular study on @entity1 showing that histopathological examination and molecular aberrations do not predict prognosis. Although the mutation frequency of @entity2 was low, we confirm the supposed relationship with central @entity1 . Moreover, we identify loss of canonical Wnt signalling and deregulation of @entity5 signalling as possible events contributing to its histogenesis.

title: @entity1 : a histopathological and molecular analysis of a rare XXXX subtype.

answer: @entity1


abstract: PURPOSE: The purpose of this study was to investigate the pro-apoptotic effect of @entity4 ( @entity1 ) on Y79 @entity0 cells and the role of Forkhead box, class O ( @entity2 ) in @entity1 -induced apoptosis. METHODS: @entity1 -induced apoptosis was determined by flow cytometry with @entity3 -FITC positive cells and Western blot of @entity5 expression, respectively. The expressions of @entity2 were detected by Western blot. The transcriptional activity of @entity2 was determined by luciferase reporter assay. siRNAs specifically inhibiting @entity2 were used, and flow cytometry and Western blot were executed to test the role of @entity2 in @entity1 -induced apoptosis. RESULTS: @entity1 was extremely effective in inducing apoptosis of Y79 @entity0 cells. @entity2 was highly expressed in Y79 cells. @entity1 not only elevated the @entity2 dephosphorylation level but also promoted its transcriptional activity, suggesting that the activation of @entity2 was, at least in part, triggered by @entity1 . The decreased @entity3 positive cells and less @entity5 cleavage demonstrated that siRNAs-mediated inhibition of @entity2 significantly abrogated @entity1 -induced apoptosis, indicating that @entity2 plays an important role in @entity1 -induced apoptosis. Moreover, the expression of Bim was also elevated with the treatment of @entity1 , which is in accordance with the activation of @entity2 . CONCLUSIONS: Our study provides the evidence that a high level of endogenous @entity2 expression in @entity0 cells contributes, at least in part, to @entity1 -induced apoptosis, which may help broad application of @entity1 in @entity0 therapy in the future.

title: @entity4 induces apoptosis of human @entity0 cells via activation of XXXX .

answer: @entity2


abstract: PURPOSE: The purpose of this study was to investigate the pro-apoptotic effect of @entity4 ( @entity1 ) on Y79 @entity0 cells and the role of Forkhead box, class O ( @entity2 ) in @entity1 -induced apoptosis. METHODS: @entity1 -induced apoptosis was determined by flow cytometry with @entity3 -FITC positive cells and Western blot of @entity5 expression, respectively. The expressions of @entity2 were detected by Western blot. The transcriptional activity of @entity2 was determined by luciferase reporter assay. siRNAs specifically inhibiting @entity2 were used, and flow cytometry and Western blot were executed to test the role of @entity2 in @entity1 -induced apoptosis. RESULTS: @entity1 was extremely effective in inducing apoptosis of Y79 @entity0 cells. @entity2 was highly expressed in Y79 cells. @entity1 not only elevated the @entity2 dephosphorylation level but also promoted its transcriptional activity, suggesting that the activation of @entity2 was, at least in part, triggered by @entity1 . The decreased @entity3 positive cells and less @entity5 cleavage demonstrated that siRNAs-mediated inhibition of @entity2 significantly abrogated @entity1 -induced apoptosis, indicating that @entity2 plays an important role in @entity1 -induced apoptosis. Moreover, the expression of Bim was also elevated with the treatment of @entity1 , which is in accordance with the activation of @entity2 . CONCLUSIONS: Our study provides the evidence that a high level of endogenous @entity2 expression in @entity0 cells contributes, at least in part, to @entity1 -induced apoptosis, which may help broad application of @entity1 in @entity0 therapy in the future.

title: @entity4 induces apoptosis of human XXXX cells via activation of @entity2 .

answer: @entity0


abstract: PURPOSE: The purpose of this study was to investigate the pro-apoptotic effect of @entity4 ( @entity1 ) on Y79 @entity0 cells and the role of Forkhead box, class O ( @entity2 ) in @entity1 -induced apoptosis. METHODS: @entity1 -induced apoptosis was determined by flow cytometry with @entity3 -FITC positive cells and Western blot of @entity5 expression, respectively. The expressions of @entity2 were detected by Western blot. The transcriptional activity of @entity2 was determined by luciferase reporter assay. siRNAs specifically inhibiting @entity2 were used, and flow cytometry and Western blot were executed to test the role of @entity2 in @entity1 -induced apoptosis. RESULTS: @entity1 was extremely effective in inducing apoptosis of Y79 @entity0 cells. @entity2 was highly expressed in Y79 cells. @entity1 not only elevated the @entity2 dephosphorylation level but also promoted its transcriptional activity, suggesting that the activation of @entity2 was, at least in part, triggered by @entity1 . The decreased @entity3 positive cells and less @entity5 cleavage demonstrated that siRNAs-mediated inhibition of @entity2 significantly abrogated @entity1 -induced apoptosis, indicating that @entity2 plays an important role in @entity1 -induced apoptosis. Moreover, the expression of Bim was also elevated with the treatment of @entity1 , which is in accordance with the activation of @entity2 . CONCLUSIONS: Our study provides the evidence that a high level of endogenous @entity2 expression in @entity0 cells contributes, at least in part, to @entity1 -induced apoptosis, which may help broad application of @entity1 in @entity0 therapy in the future.

title: XXXX induces apoptosis of human @entity0 cells via activation of @entity2 .

answer: @entity4


abstract: PURPOSE: Chronic therapy with long-acting bronchodilators (LB) is recommended to treat moderate-to-severe @entity1 . Although the benefits of adding @entity2 ( @entity2 ) to LB are still unclear, @entity0 who experience repeated exacerbations are suggested to add @entity2 to their LB treatment. The objective of this study is to analyze whether adding @entity2 to LB therapy reduces mortality. METHODS: We identified a cohort of @entity0 discharged from hospital with @entity1 diagnosis between 2006 and 2009. The first prescription for LB or @entity2 following discharge was defined as the index prescription. Only new users were included (no use of any study drug in the 6 months before treatment). A 4-day time window was used to classify @entity0 into "LB alone" or "LB plus @entity2 " initiators. We used propensity score to balance the study groups. Sensitivity analyses were performed in @entity0 with recent out-of-hospital exacerbations. RESULTS: Among the 18615 adults enrolled, 12207 initiated "LB plus @entity2 " therapy and 6408 "LB alone." Crude mortality rates were 110 and 143 cases per 1000 @entity0 -years in the "LB plus @entity2 " and "LB alone" groups, respectively. The adjusted hazard ratio (HR) was 0.83 (95% CI: 0.72-0.97; p-value: 0.024). When analyzing @entity0 with recent out-of-hospital exacerbations, the benefit of the combination therapy was more pronounced, HR = 0.63 (95% CI: 0.44-0.90; p-value: 0.012). DISCUSSION: Our findings showed a beneficial effect on mortality of adding inhaled corticosteroids to long-acting bronchodilators. The advantage was much more pronounced in @entity0 with frequent exacerbations.

title: The Effect on Total Mortality of Adding Inhaled Corticosteroids to Long-Acting Bronchodilators for XXXX : A Real Practice Analysis in Italy.

answer: @entity1


abstract: OBJECTIVE: To compare the effect of Magnolia officinalis and M. officinalis var. biloba on @entity0 . METHOD: The @entity0 induced by @entity3 and @entity1 were used in this study. The effect of M. officinalis on the gastrointestinal function was evaluated by propulsive motility of the total gastrointestinal tract test by recording the time of excreting carbo medicinalis, the gastric residualrate, the intestinal propulsion rate, the serum levels of @entity4 , @entity2 ( @entity2 ) and @entity5 (GAS). ED50 were calculated with Bliss's method. RESULT: M. officinalis and M. officinalis var. biloba improved the @entity0 , decreased the gastric residual rate, enhanced the intestinal propulsion rate and increased serum levels of @entity4 , @entity2 ( @entity2 ) and @entity5 (GAS). The ED50 value of M. officinalis var. biloba was much higher than that of M. officinalis. CONCLUSION: The effect of improving @entity0 of M. officinalis was proved to be superior to that of M. officinalis var. biloba.

title: [Comparative study of effect of Magnolia officinalis and M. officinalis var. biloba on XXXX ].

answer: @entity0


abstract: Video techniques were used to analyze the motion of the gliding bacterium Cytophaga sp. strain @entity3 . Cells moved singly on glass along the long axis at a speed of about 2 micrometers/s, advancing, retreating, stopping, pivoting about a pole, or flipping over. They did not flex or roll. Cells of different lengths moved at about the same speed. Cells sometimes spun continuously about a pole at a frequency of about 2 HZ, the body moving in a plane parallel to that of the glass or on the surface of a cone having either a large or a small solid angle. @entity2 latex spheres moved to and fro on the surfaces of cells, also at a speed of about 2 micrometers/s. They moved in the same fashion whether a cell was in suspension, gliding, or at rest on the glass. Two spheres on the same cell often moved in opposite directions, passing by one another in close proximity. Small and large spheres and aggregates of spheres all moved at about the same speed. An aggregate moved down the side of a cell with a fixed orientation, even when only one sphere was in contact with the cell. Spheres occasionally left one cell and were picked up by another. Cell pretreated with small spheres did not adhere to glass. When the cells were deprived of @entity0 , they stopped gliding, and the spheres stopped moving on their surfaces. The spheres became completely immobilized; they no longer moved from cell to cell or exhibited @entity1 . Cytophaga spp. are known to have a typical gram-negative cell envelope: an inner (cytoplasmic) membrane, a thin peptidoglycan layer, and an outer (lipopolysaccharide) membrane. Our data are consistent with a model for gliding in which sites to which glass and @entity2 strongly adsorb move within the fluid outer membrane along tracks fixed to the rigid peptidoglycan framework.

title: Gliding motility of Cytophaga sp. strain XXXX .

answer: @entity3


abstract: We describe the development, implementation, and outcomes of the first 2 years of the @entity1 CarePath, an initiative developed for management of @entity2 @entity0 in an effort to improve efficiency and quality of care for @entity0 . The CarePath consists of care pathways for @entity2 that are integrated within the electronic health record. @entity0 -reported outcomes are collected using an external software platform. Documentation tools, order sets, and clinical decision support were designed to improve efficiency, optimize process measure adherence, and produce clinical data as a byproduct of care that are available for future analyses. Inpatient mortality and length of stay were compared before and after CarePath implementation in @entity2 @entity0 after adjustment for case-mix. Postdischarge functional outcomes of @entity0 with @entity2 were compared between the first 3 months of rollout and remainder of the study period. From January 2011 to December 2012, there were 1106 @entity0 with @entity2 on the CarePath. There was a decline in inpatient mortality in @entity0 with @entity2 , but not in control @entity0 with @entity3 . Completion rate of @entity0 -reported questionnaires at postdischarge @entity1 follow-up was 72.9%. There was a trend toward improved functional outcomes at follow-up with CarePath implementation. Implementation of the @entity1 CarePath is feasible and may be associated with a benefit in multiple different outcomes after @entity2 . This approach may be an important strategy for optimizing @entity1 care in the future.

title: XXXX CarePath: Integrated Approach to @entity1 Care.

answer: @entity1


abstract: We describe the development, implementation, and outcomes of the first 2 years of the @entity1 CarePath, an initiative developed for management of @entity2 @entity0 in an effort to improve efficiency and quality of care for @entity0 . The CarePath consists of care pathways for @entity2 that are integrated within the electronic health record. @entity0 -reported outcomes are collected using an external software platform. Documentation tools, order sets, and clinical decision support were designed to improve efficiency, optimize process measure adherence, and produce clinical data as a byproduct of care that are available for future analyses. Inpatient mortality and length of stay were compared before and after CarePath implementation in @entity2 @entity0 after adjustment for case-mix. Postdischarge functional outcomes of @entity0 with @entity2 were compared between the first 3 months of rollout and remainder of the study period. From January 2011 to December 2012, there were 1106 @entity0 with @entity2 on the CarePath. There was a decline in inpatient mortality in @entity0 with @entity2 , but not in control @entity0 with @entity3 . Completion rate of @entity0 -reported questionnaires at postdischarge @entity1 follow-up was 72.9%. There was a trend toward improved functional outcomes at follow-up with CarePath implementation. Implementation of the @entity1 CarePath is feasible and may be associated with a benefit in multiple different outcomes after @entity2 . This approach may be an important strategy for optimizing @entity1 care in the future.

title: @entity1 CarePath: Integrated Approach to XXXX Care.

answer: @entity1


abstract: BACKGROUND: In 2009 it was introduced a new diagnostic criteria based on hemoglobin A1c (HbA1c) greater than or equal to 6.5 % in the adult population; some studies suggest that the cutoff may be smaller in pediatric population. The objective was to determine the utility of HbA1c greater than or equal to 6.5 % as a diagnostic test for @entity3 in Mexican adolescents with overweight or @entity0 . METHODS: Full somatometry was performed. Also, Tanner stage, blood pressure, blood @entity1 , @entity1 tolerance curve (GTC) and HbA1c were analyzed. Specificity, sensitivity, positive and negative predictive values and ROC curve were calculated for the diagnosis of @entity3 with HbA1c. RESULTS: 109 adolescents between 10 and 16 years referred for @entity0 or overweight plus comorbidities were studied; 58 % were females, the age was of 13    1.74 years, the BMI percentile 95.3, and the HbA1c 5.73    0.9 %. It was made a diagnosis of @entity3 in 9 cases (8.3 %), @entity4 in 8 (7.3 %) and normal @entity1 tolerance in 92 (84.4 %). The HbA1c mean was 5.6    0.04, 5.7    0.4, and 5.6    0.73 %, respectively. HbA1c greater than or equal to 6.5 % had a sensitivity of 12.5 %, a specificity of 89.8 %, a @entity2 of 10.65 and a NPV of 14.28. The best cutoff point for diagnosing @entity3 through ROC curve was 5.45 %, with a sensitivity of 62.5 %, a specificity of 57.1 %, @entity2 2.53 and NPV 33.3. CONCLUSIONS: The level of HbA1c greater than or equal to 6.5 % had low sensitivity and specificity for the diagnosis of @entity3 . A lower cutoff point is insufficient to use HbA1c as a diagnostic criterion. These results are consistent with the ones of other journals.

title: [Glycosylated hemoglobin A1c as a diagnostic test for diabetes mellitus in adolescents with overweight and XXXX ].

answer: @entity0


abstract: OBJECTIVE: To report a series of three @entity0 who received simultaneous circulatory support with both veno-arterial extracorporeal membrane oxygenation and intra-aortic balloon pump and subsequently developed @entity5 , and present a brief review of the relevant literature. DATA SOURCES: Hospital medical records and MEDLINE and PubMed databases. STUDY SELECTION: Any @entity0 who developed lower limb neurologic symptoms during a period of concurrent venoarterial extracorporeal membrane oxygenation and intra-aortic balloon pump support, with subsequent MRI changes involving the spinal cord, from 2006 (the year of institution of venoarterial extracorporeal membrane oxygenation in our ICU) to 2014. DATA EXTRACTION: @entity0 records were retrospectively reviewed. Medical databases were searched for any literature linking intra-aortic balloon pump and/or venoarterial extracorporeal membrane oxygenation with @entity1 of the lower limbs. DATA SYNTHESIS: Three female @entity0 presented in @entity6 or arrest requiring circulatory support. Intra-aortic balloon pump was inserted, and peripheral veno-arterial extracorporeal membrane oxygenation was initiated with subsequent loss of native ejection in each case. Neurologic signs were noted clinically, and subsequent imaging demonstrated @entity5 and small aortic size for all three @entity0 . CONCLUSIONS: The timeline of events suggests a causal relation between intra-aortic balloon pump, veno-arterial extracorporeal membrane oxygenation, and significant @entity2 . This is likely due to hypoperfusion of the spinal cord, which is multifactorial in origin, including small aortic calibre, low cardiac output states, high vasopressor requirements causing vasospasm of the artery of Adamkiewicz, occlusion of retrograde oxygenated blood flow from peripheral veno-arterial extracorporeal membrane oxygenation due to intra-aortic balloon pump being in situ, and possible @entity4 phenomena. The thoracic spinal cord is intrinsically susceptible to @entity3 due to the anatomy of the arterial supply, which is described here. We identify several risk factors and make several recommendations to avoid this rare but catastrophic complication in the future. We also suggest interventions should this challenging complication be identified.

title: XXXX During Concomitant Circulatory Support With Intra-Aortic Balloon Pump and Veno-Arterial Extracorporeal Membrane Oxygenation.

answer: @entity5


abstract: BACKGROUND: The circadian pattern of adipokines is blunted in @entity1 subjects, and we tested the hypothesis that bariatric surgery could normalize the 24-hr pattern of adipokines. Therefore, this study was designed to examine the early impact of the newly designed sleeve gastrectomy with transit bipartition ( @entity3 ) surgery on the circadian pattern of leptin, @entity2 , and resistin in morbidly @entity1 subjects. METHODS: The study group included six morbidly @entity1 @entity0 [body mass index (BMI) 41.3        1.53   kg/m(2)] who underwent @entity3 and four lean @entity0 (BMI 18.61        0.92   kg/m(2)). Blood from all subjects was collected before and 3 months after bariatric surgery every 6   hr throughout the 24-hr period. The circadian pattern of leptin, @entity2 , and resistin was measured by enzyme-linked immunosorbent assay or Luminex techniques. RESULTS: Lean @entity0 exhibited rise of plasma leptin levels at nighttime, whereas @entity1 @entity0 had an increase in the overall plasma leptin levels throughout the 24-hr period, lacking the physiological rise of nocturnal leptin levels compared to controls. Obese @entity0 had a decrease in 24-hr @entity2 levels and similar plasma resistin levels compared to controls. Three months after @entity3 , @entity1 @entity0 lost 16.0% (P   <   0.005) of their initial body weight and had a decrease in overall 24-hr leptin levels. However, there was no recovery of the nocturnal rise in leptin levels 3 months after @entity3 . The 24-hr @entity2 levels were still decreased after @entity3 surgery compared to controls, while resistin levels were decreased only during night time after @entity3 . CONCLUSIONS: These results suggested that @entity3 is an efficient innovative procedure to rapidly decrease 24-hr leptin levels. However, after 3 months, @entity3 was not enough to recover the physiological nocturnal rise of leptin levels present in lean subjects.

title: Early Effect of Bariatric Surgery on the Circadian Rhythms of Adipokines in Morbidly Obese XXXX .

answer: @entity0


abstract: BACKGROUND: Gunshot wounds require surgeons to decide whether to remove or leave bullet fragments in the body. Surgeons also decide how to follow up with @entity0 who have lead fragments retained in their body. Current literature recommends to remove only intra-articular fragments without the need for a follow-up for @entity0 with the metal retained. Therefore, this study investigates chronic @entity2 for gunshot wounds. METHODS: The study was performed in the metropolitan area of Rio de Janeiro/Brazil, between 2013 and 2015. It was a case-control study that included 45 victims of gunshot lesions with metallic fragments retained for more than 6 months. The 45 controls were matched for gender, age, and race. We compared the lead blood levels and frequency of symptoms. RESULTS: The control group had average blood lead levels of 2.17  g/dL (95% Confidence Interval [CI]; 1.71-2.63) and median 2.1  g/dL. The case group had average values of 9.01  g/dL (CI; 6.07-11.96) and median values of 6.5  g/dL with p-values < = 0.001. The case group reported the following more frequently: irritancy, bad mood, @entity1 , @entity7 , daylight drowsiness, @entity6 , @entity4 , @entity5 , @entity3 , @entity8 , tingling limbs. There was statistical significance for the differences of symptoms frequencies and for odds ratio between groups. CONCLUSIONS: Although the mean lead levels found were lower than the current laboratory references, low levels have been associated with both rising morbidity and mortality. The WHO stated: "There is no known level of lead exposure that is considered safe". In conclusion, this work showed that bullets retained in the body are not innocuous. There are impacts in the blood lead levels and symptoms related to it, even with few fragments, extra-articular located or existing with low blood lead levels.

title: Lead XXXX Risks in Gunshot Victims.

answer: @entity2


abstract: AIMS: To investigate whether @entity5 polymorphisms affect peginterferon alpha (PEG-IFN) efficacy in @entity4 ( @entity4 ) @entity0 using a tag- single nucleotide polymorphism (SNP) approach. METHODS: A total of 212 @entity3 e antigen (HBeAg)-positive @entity0 treated with a 48weeks of PEG-IFN monotherapy were enrolled initially and 127 @entity0 were followed for 48weeks posttreatment. Genotype analysis was performed for 10 tag-SNPs in @entity5 . RESULTS: The @entity2 ( @entity2 ) rate was 45.8% (97/212) and the sustained virological response (SVR) rate was 45.7% (58/127). Meanwhile, 35.4% (75/212) achieved HBeAg seroconversion at the end of treatment. In a multivariate analysis, the @entity6 CC genotype was independently associated with @entity2 (OR 2.21, 95% CI 1.23-3.98, P=0.008) and SVR (OR 2.34, 95% CI 1.05-5.20, P=0.037) after adjustment for sex, age, @entity1 genotype, baseline levels of @entity1 DNA and ALT. Meanwhile, @entity6 CC genotype were also independently associated with decline of HBsAg levels below 1500IU/mL at 12weeks of treatment (OR 2.52, 95% CI 1.01-6.29, P=0.047). Furthermore, three SNPs were found to be independently associated with HBeAg seroconversion at the end of treatment. (1) The @entity7 CC genotype was independently associated with no HBeAg seroconversion (OR 0.52, 95% CI 0.29-0.95, P=0.034); (2) The @entity8 TT genotype was independently associated with HBeAg seroconversion (OR 2.11, 95% CI 1.14-3.90, P=0.017); (3) The @entity6 CC genotype was independently associated with HBeAg seroconversion (OR 2.36, 95% CI 1.26-4.42, P=0.007). CONCLUSIONS: Polymorphisms in @entity5 are independently associated with treatment response to PEG-IFN among Chinese HBeAg-positive @entity4 @entity0 .

title: Association of @entity5 polymorphisms with peginterferon efficacy in XXXX with HBeAg-positive in the Chinese population.

answer: @entity4


abstract: AIMS: To investigate whether @entity5 polymorphisms affect peginterferon alpha (PEG-IFN) efficacy in @entity4 ( @entity4 ) @entity0 using a tag- single nucleotide polymorphism (SNP) approach. METHODS: A total of 212 @entity3 e antigen (HBeAg)-positive @entity0 treated with a 48weeks of PEG-IFN monotherapy were enrolled initially and 127 @entity0 were followed for 48weeks posttreatment. Genotype analysis was performed for 10 tag-SNPs in @entity5 . RESULTS: The @entity2 ( @entity2 ) rate was 45.8% (97/212) and the sustained virological response (SVR) rate was 45.7% (58/127). Meanwhile, 35.4% (75/212) achieved HBeAg seroconversion at the end of treatment. In a multivariate analysis, the @entity6 CC genotype was independently associated with @entity2 (OR 2.21, 95% CI 1.23-3.98, P=0.008) and SVR (OR 2.34, 95% CI 1.05-5.20, P=0.037) after adjustment for sex, age, @entity1 genotype, baseline levels of @entity1 DNA and ALT. Meanwhile, @entity6 CC genotype were also independently associated with decline of HBsAg levels below 1500IU/mL at 12weeks of treatment (OR 2.52, 95% CI 1.01-6.29, P=0.047). Furthermore, three SNPs were found to be independently associated with HBeAg seroconversion at the end of treatment. (1) The @entity7 CC genotype was independently associated with no HBeAg seroconversion (OR 0.52, 95% CI 0.29-0.95, P=0.034); (2) The @entity8 TT genotype was independently associated with HBeAg seroconversion (OR 2.11, 95% CI 1.14-3.90, P=0.017); (3) The @entity6 CC genotype was independently associated with HBeAg seroconversion (OR 2.36, 95% CI 1.26-4.42, P=0.007). CONCLUSIONS: Polymorphisms in @entity5 are independently associated with treatment response to PEG-IFN among Chinese HBeAg-positive @entity4 @entity0 .

title: Association of XXXX polymorphisms with peginterferon efficacy in @entity4 with HBeAg-positive in the Chinese population.

answer: @entity5


abstract: @entity9 is now exceptional. Symptomatology is non-specific and frequently, as in the case reported here, the onset is marked by a localized or generalized @entity4 . A space-occupying lesion is recognized by angiography and CT. The precise diagnosis is suggested by evidence of @entity7 or of a hypodense mass outlined by contrast or slight calcifications and confirmed by positive serology in a @entity0 with a suspected @entity1 . In some cases a positive diagnosis can be made only by pathological examination after surgical ablation of the gumma. An area of central @entity2 is surrounded by a granulomatous layer rich in plasmocytes (the polyclonal nature of the secretion is shown by immunocytochemistry) and a peripheral fibroblastic zone. The arteries are ensheathed by a dense inflammatory infiltrate constituted almost entirely by plasmocytes and their lumens are either stenosed or filled with @entity8 . Surgical treatment should be combined with @entity3 administration. For a @entity0 in good general condition with a suspected gumma, medical treatment can be given initially, with follow-up by CT, neurosurgery being indicated only in case of failure of medical therapy. The rarity of gummata in relation to other tertiary syphilitic lesions remains unexplained. The @entity0 reported here had multiple infections including one due to @entity6 after ablation of the gumma, highly suggesting an @entity5 .

title: [Surgically treated XXXX of the brain. Computerized tomography findings].

answer: @entity9


abstract: A retrospective study of 223 @entity0 (111 @entity0 , 112 @entity0 , mean age 40.6 years) with the @entity9 investigated vital or functional prognostic factors. @entity0 were first seen between 1963 and 1981, when 192 were noted to have @entity4 . Assisted ventilation was required in 152 cases, and 23 @entity0 died, including 5 from cardiocirculatory dysautonomy. Plasma exchange was not used. @entity0 were divided into 3 groups as a function of the degree of maximum @entity5 : group 1 (n = 63) @entity0 had incomplete @entity6 without assisted ventilation, group 2 (n = 93) incomplete @entity6 with assisted ventilation, group 3 (n = 62) @entity6 with or without assisted ventilation. Vital prognosis was related to the severity of @entity1 . Frequency of intercurrent complications, @entity3 and mortality increased with maximal severity of @entity2 . The 3 groups did not differ as a function of previous history, mode of onset of @entity10 , duration of extension phase of @entity5 , or @entity7 protein content at the first examination during the extension phase of the paralyses. It is therefore impossible at an early stage of the disease to predict future @entity2 . The cumulative percentage of @entity0 who recovered a normal muscular force in limbs and cranial territories was 48 p. 100 after one year and 60 p. 100 after two years (actuarial values). The functional prognosis depends upon the degree of @entity2 at maximum @entity5 and duration of the plateau phase. Probability of full muscular strength recovery was lower in group 3 and in those @entity0 with a plateau phase duration longer than 2 weeks. Independently of groups, motility recovery rate was markedly higher in @entity0 with a plateau phase duration of less than one week. Motility recuperation was independent of age, sex, duration of extension phase, @entity7 protein levels during the acute phase, and presence of @entity8 .

title: [The XXXX . Study of prognostic factors in 223 cases].

answer: @entity9


abstract: UNASSIGNED: Although @entity3 symptom severity and impairment are overlapping but nevertheless distinct illness parameters, little research has examined whether variables found to be associated with the severity are also correlated with symptom-induced impairment. Parents and teachers completed ratings of symptom-induced @entity2 , and parents completed a background questionnaire for a consecutively referred sample of primarily male (81  %) 6-to-12  year olds with @entity1 ( @entity1 ) (N   =   221). Some clinical correlates (e.g., IQ   <   70, maternal level of education, pregnancy complications, current use of psychotropic medication, season of birth) were associated with @entity2 , whereas others were correlated with only a few syndromes (e.g., gender, co-morbid medical conditions) or were not related to @entity2 (e.g., family psychopathology). There was little convergence in findings for parents' versus teachers' ratings. Some clinical correlates (e.g., season of birth, current psychotropic medication, maternal education) were unique predictors of three or more disorders. Pregnancy complications were uniquely associated with social @entity4 and @entity9 symptom-induced impairment. IQ was a unique predictor of @entity5 , @entity1 , @entity8 symptom-induced impairment. @entity0 whose mothers had relatively fewer years of education had greater odds for symptom-induced @entity2 , @entity7 , @entity3 , and @entity6 and greater number of impairing conditions. Season of birth was the most robust correlate of symptom-induced impairment as rated by teachers but not by parents. @entity0 born in fall evidenced higher rates of co-occurring @entity3 and @entity1 symptom-induced @entity2 of impairing conditions. Many variables previously linked with symptom severity are also correlated with impairment.

title: Clinical Correlates of Co-occurring Psychiatric and @entity1 ( @entity1 ) Symptom-Induced Impairment in @entity0 with XXXX .

answer: @entity1


abstract: UNASSIGNED: Although @entity3 symptom severity and impairment are overlapping but nevertheless distinct illness parameters, little research has examined whether variables found to be associated with the severity are also correlated with symptom-induced impairment. Parents and teachers completed ratings of symptom-induced @entity2 , and parents completed a background questionnaire for a consecutively referred sample of primarily male (81  %) 6-to-12  year olds with @entity1 ( @entity1 ) (N   =   221). Some clinical correlates (e.g., IQ   <   70, maternal level of education, pregnancy complications, current use of psychotropic medication, season of birth) were associated with @entity2 , whereas others were correlated with only a few syndromes (e.g., gender, co-morbid medical conditions) or were not related to @entity2 (e.g., family psychopathology). There was little convergence in findings for parents' versus teachers' ratings. Some clinical correlates (e.g., season of birth, current psychotropic medication, maternal education) were unique predictors of three or more disorders. Pregnancy complications were uniquely associated with social @entity4 and @entity9 symptom-induced impairment. IQ was a unique predictor of @entity5 , @entity1 , @entity8 symptom-induced impairment. @entity0 whose mothers had relatively fewer years of education had greater odds for symptom-induced @entity2 , @entity7 , @entity3 , and @entity6 and greater number of impairing conditions. Season of birth was the most robust correlate of symptom-induced impairment as rated by teachers but not by parents. @entity0 born in fall evidenced higher rates of co-occurring @entity3 and @entity1 symptom-induced @entity2 of impairing conditions. Many variables previously linked with symptom severity are also correlated with impairment.

title: Clinical Correlates of Co-occurring Psychiatric and XXXX ( @entity1 ) Symptom-Induced Impairment in @entity0 with @entity1 .

answer: @entity1


abstract: UNASSIGNED: Although @entity3 symptom severity and impairment are overlapping but nevertheless distinct illness parameters, little research has examined whether variables found to be associated with the severity are also correlated with symptom-induced impairment. Parents and teachers completed ratings of symptom-induced @entity2 , and parents completed a background questionnaire for a consecutively referred sample of primarily male (81  %) 6-to-12  year olds with @entity1 ( @entity1 ) (N   =   221). Some clinical correlates (e.g., IQ   <   70, maternal level of education, pregnancy complications, current use of psychotropic medication, season of birth) were associated with @entity2 , whereas others were correlated with only a few syndromes (e.g., gender, co-morbid medical conditions) or were not related to @entity2 (e.g., family psychopathology). There was little convergence in findings for parents' versus teachers' ratings. Some clinical correlates (e.g., season of birth, current psychotropic medication, maternal education) were unique predictors of three or more disorders. Pregnancy complications were uniquely associated with social @entity4 and @entity9 symptom-induced impairment. IQ was a unique predictor of @entity5 , @entity1 , @entity8 symptom-induced impairment. @entity0 whose mothers had relatively fewer years of education had greater odds for symptom-induced @entity2 , @entity7 , @entity3 , and @entity6 and greater number of impairing conditions. Season of birth was the most robust correlate of symptom-induced impairment as rated by teachers but not by parents. @entity0 born in fall evidenced higher rates of co-occurring @entity3 and @entity1 symptom-induced @entity2 of impairing conditions. Many variables previously linked with symptom severity are also correlated with impairment.

title: Clinical Correlates of Co-occurring Psychiatric and @entity1 ( XXXX ) Symptom-Induced Impairment in @entity0 with @entity1 .

answer: @entity1


abstract: UNASSIGNED: Although @entity3 symptom severity and impairment are overlapping but nevertheless distinct illness parameters, little research has examined whether variables found to be associated with the severity are also correlated with symptom-induced impairment. Parents and teachers completed ratings of symptom-induced @entity2 , and parents completed a background questionnaire for a consecutively referred sample of primarily male (81  %) 6-to-12  year olds with @entity1 ( @entity1 ) (N   =   221). Some clinical correlates (e.g., IQ   <   70, maternal level of education, pregnancy complications, current use of psychotropic medication, season of birth) were associated with @entity2 , whereas others were correlated with only a few syndromes (e.g., gender, co-morbid medical conditions) or were not related to @entity2 (e.g., family psychopathology). There was little convergence in findings for parents' versus teachers' ratings. Some clinical correlates (e.g., season of birth, current psychotropic medication, maternal education) were unique predictors of three or more disorders. Pregnancy complications were uniquely associated with social @entity4 and @entity9 symptom-induced impairment. IQ was a unique predictor of @entity5 , @entity1 , @entity8 symptom-induced impairment. @entity0 whose mothers had relatively fewer years of education had greater odds for symptom-induced @entity2 , @entity7 , @entity3 , and @entity6 and greater number of impairing conditions. Season of birth was the most robust correlate of symptom-induced impairment as rated by teachers but not by parents. @entity0 born in fall evidenced higher rates of co-occurring @entity3 and @entity1 symptom-induced @entity2 of impairing conditions. Many variables previously linked with symptom severity are also correlated with impairment.

title: Clinical Correlates of Co-occurring Psychiatric and @entity1 ( @entity1 ) Symptom-Induced Impairment in XXXX with @entity1 .

answer: @entity0


abstract: UNASSIGNED: In @entity2 ( @entity2 ), freezing of gait ( @entity5 ) is associated with widespread functional and structural gray matter changes throughout the brain. Previous study of freezing-related white matter changes was restricted to brainstem and cerebellar locomotor tracts. This study was undertaken to determine the spatial distribution of white matter damage associated with @entity5 by combining whole brain and striatofrontal seed-based diffusion tensor imaging. Diffusion-weighted images were collected in 26 @entity2 @entity0 and 16 age-matched controls. @entity2 groups with (n   =   11) and without freezing of gait (n   =   15) were matched for age and disease severity. We applied tract-based spatial statistics to compare fractional anisotropy and mean diffusivity of white matter structure across the whole brain between groups. Probabilistic tractography was used to evaluate fractional anisotropy and mean diffusivity of key subcortico-cortical tracts. Tract-based spatial statistics revealed decreased fractional anisotropy in @entity2 with @entity5 in bilateral cerebellar and superior @entity4 . Increased mean diffusivity values were apparent in the right internal capsule, superior frontal cortex, anterior corona radiata, the @entity6 , and cerebellum. Tractography showed consistent white matter alterations in striatofrontal tracts through the putamen, caudate, pallidum, subthalamic nucleus, and in connections of the cerebellar peduncle with subthalamic nucleus and pedunculopontine nucleus bilaterally. We conclude that @entity5 is associated with diffuse white matter damage involving major cortico-cortical, corticofugal motor, and several striatofrontal tracts in addition to previously described cerebello-pontine connectivity changes. These distributed @entity1 may contribute to the motor and non-motor correlates of @entity5 .    2015 International Parkinson and @entity3 Society.

title: XXXX associated with freezing of gait in @entity2 .

answer: @entity1


abstract: UNASSIGNED: In @entity2 ( @entity2 ), freezing of gait ( @entity5 ) is associated with widespread functional and structural gray matter changes throughout the brain. Previous study of freezing-related white matter changes was restricted to brainstem and cerebellar locomotor tracts. This study was undertaken to determine the spatial distribution of white matter damage associated with @entity5 by combining whole brain and striatofrontal seed-based diffusion tensor imaging. Diffusion-weighted images were collected in 26 @entity2 @entity0 and 16 age-matched controls. @entity2 groups with (n   =   11) and without freezing of gait (n   =   15) were matched for age and disease severity. We applied tract-based spatial statistics to compare fractional anisotropy and mean diffusivity of white matter structure across the whole brain between groups. Probabilistic tractography was used to evaluate fractional anisotropy and mean diffusivity of key subcortico-cortical tracts. Tract-based spatial statistics revealed decreased fractional anisotropy in @entity2 with @entity5 in bilateral cerebellar and superior @entity4 . Increased mean diffusivity values were apparent in the right internal capsule, superior frontal cortex, anterior corona radiata, the @entity6 , and cerebellum. Tractography showed consistent white matter alterations in striatofrontal tracts through the putamen, caudate, pallidum, subthalamic nucleus, and in connections of the cerebellar peduncle with subthalamic nucleus and pedunculopontine nucleus bilaterally. We conclude that @entity5 is associated with diffuse white matter damage involving major cortico-cortical, corticofugal motor, and several striatofrontal tracts in addition to previously described cerebello-pontine connectivity changes. These distributed @entity1 may contribute to the motor and non-motor correlates of @entity5 .    2015 International Parkinson and @entity3 Society.

title: @entity1 associated with freezing of gait in XXXX .

answer: @entity2


abstract: PURPOSE: To validate imaging parameters from diffusion-weighted imaging and dynamic contrast-enhanced MRI with immunohistology and to non-invasively assess microstructure of experimental @entity0 . MATERIALS AND METHODS: Animals bearing @entity0 were imaged in a clinical 1.5T MRI scanner. HASTE sequences were performed to calculate apparent diffusion coefficients. Saturation recovery turbo FLASH sequences were conducted while infusing 0.1mmol/l @entity3 for dynamic contrast-enhanced MRI to quantify parameters amplitude A and exchange rate constant kep. After imaging, bone @entity1 were analyzed immunohistologically. RESULTS: We found correlations of the apparent diffusion coefficients from diffusion-weighted imaging with @entity2 cellularity as assessed with cell nuclei staining. Histological vessel maturity was correlated negatively with parameters A and kep from dynamic contrast-enhanced MRI. @entity2 size correlated inversely with cell density and vessel permeability as well as positively with mean vessel calibers. Parameters from the rim of bone @entity1 differed significantly from values of the center. CONCLUSION: In vivo diffusion-weighted imaging and dynamic contrast-enhanced MRI in experimental bone @entity1 provide information about @entity2 cellularity and vascularity and correlate well with immunohistology.

title: Diffusion-weighted imaging and dynamic contrast-enhanced MRI of experimental XXXX - A correlation study with histology.

answer: @entity0


abstract: @entity4 after chronic @entity3 consumption results from an increase in cell size and not in cell number. About 50--60% of the increase in liver weight is accounted for by an increase in intracellular water, while extracellular water remains constant. Therefore, a substantial reduction in the ratio of extracellular to intracellular water occurs. Intracellular @entity5 can osmotically account for 40--50% of the excess water retained in the hepatocytes. It is proposed that an increase in hepatocyte size after chronic @entity3 consumption compresses vascular-sinusoidal pathways. This results, after a threshold in cell size is exceeded, in increased intrahepatic and portal pressure. Possible factors responsible for the threshold are proposed. By applying the concept that animal cells act as osmometers, a new in vitro model has been developed to study the relationship between cell enlargement and portal pressure. In this model, the existence of a threshold and the generation of portal @entity2 associated with hepatocyte enlargement have been demonstrated. In @entity0 with @entity6 , a threshold in hepatocyte size enlargement (1600--1700 micrometer 2) before pressures were increased was also observed. In these @entity0 , a strong correlation was also found between hepatocyte size and intrahepatic pressure. The same correlation occurs regardless of the presence or absence of @entity1 , therefore suggesting that a major determinant of portal @entity2 in @entity1 is cell size and not the existence of nodules of fibrous septa. The higher portal pressures found in cirrhotics may be explained by the fact that these @entity0 have larger hepatocytes.

title: XXXX -induced @entity4 : pathogenesis and role in the production of portal @entity2 .

answer: @entity3


abstract: @entity4 after chronic @entity3 consumption results from an increase in cell size and not in cell number. About 50--60% of the increase in liver weight is accounted for by an increase in intracellular water, while extracellular water remains constant. Therefore, a substantial reduction in the ratio of extracellular to intracellular water occurs. Intracellular @entity5 can osmotically account for 40--50% of the excess water retained in the hepatocytes. It is proposed that an increase in hepatocyte size after chronic @entity3 consumption compresses vascular-sinusoidal pathways. This results, after a threshold in cell size is exceeded, in increased intrahepatic and portal pressure. Possible factors responsible for the threshold are proposed. By applying the concept that animal cells act as osmometers, a new in vitro model has been developed to study the relationship between cell enlargement and portal pressure. In this model, the existence of a threshold and the generation of portal @entity2 associated with hepatocyte enlargement have been demonstrated. In @entity0 with @entity6 , a threshold in hepatocyte size enlargement (1600--1700 micrometer 2) before pressures were increased was also observed. In these @entity0 , a strong correlation was also found between hepatocyte size and intrahepatic pressure. The same correlation occurs regardless of the presence or absence of @entity1 , therefore suggesting that a major determinant of portal @entity2 in @entity1 is cell size and not the existence of nodules of fibrous septa. The higher portal pressures found in cirrhotics may be explained by the fact that these @entity0 have larger hepatocytes.

title: @entity3 -induced XXXX : pathogenesis and role in the production of portal @entity2 .

answer: @entity4


abstract: @entity4 after chronic @entity3 consumption results from an increase in cell size and not in cell number. About 50--60% of the increase in liver weight is accounted for by an increase in intracellular water, while extracellular water remains constant. Therefore, a substantial reduction in the ratio of extracellular to intracellular water occurs. Intracellular @entity5 can osmotically account for 40--50% of the excess water retained in the hepatocytes. It is proposed that an increase in hepatocyte size after chronic @entity3 consumption compresses vascular-sinusoidal pathways. This results, after a threshold in cell size is exceeded, in increased intrahepatic and portal pressure. Possible factors responsible for the threshold are proposed. By applying the concept that animal cells act as osmometers, a new in vitro model has been developed to study the relationship between cell enlargement and portal pressure. In this model, the existence of a threshold and the generation of portal @entity2 associated with hepatocyte enlargement have been demonstrated. In @entity0 with @entity6 , a threshold in hepatocyte size enlargement (1600--1700 micrometer 2) before pressures were increased was also observed. In these @entity0 , a strong correlation was also found between hepatocyte size and intrahepatic pressure. The same correlation occurs regardless of the presence or absence of @entity1 , therefore suggesting that a major determinant of portal @entity2 in @entity1 is cell size and not the existence of nodules of fibrous septa. The higher portal pressures found in cirrhotics may be explained by the fact that these @entity0 have larger hepatocytes.

title: @entity3 -induced @entity4 : pathogenesis and role in the production of portal XXXX .

answer: @entity2


abstract: This retrospective review of 136 @entity0 with idiopathic @entity5 assesses the prognostic significance of various presenting parameters and the effect of therapy. Initial haemoglobin, white cell count, actual platelet count, @entity2 , @entity3 and @entity6 had no significant effect upon the final outcome. Cases of acute I.T.P. were associated with a higher incidence of preceding infection, a shorter history of @entity4 and a preponderance of males. The presence of greater than 20 per cent lymphocytes in the bone marrow was associated with a longer time to achieve a normal platelet count (p = 0.05). @entity1 therapy shortened the time for acute cases of I.T.P. to obtain a normal platelet count (p = 0.05), but had no effect on long-term prognosis. Chronicity occurred in 25 @entity0 (18%) and nine of these had spontaneous remissions. Immunosuppressive therapy was ineffective, but nine out of 12 @entity0 were cured by splenectomy. Mortality was 0.7 per cent (one death) and general morbidity was low.

title: XXXX in childhood. Edinburgh experience 1962-82.

answer: @entity5


abstract: UNASSIGNED: The @entity2 ( @entity2 ) is involved in the regulation of various cellular processes and dysregulation of its signalling plays a critical role in the etiology of a variety of @entity1 like @entity0 . At the same time, elevated levels of urokinase ( @entity5 ), its receptor @entity7 , and other components of the plasminogen activation system are found to be correlated with a poor prognosis in @entity0 . Interestingly, @entity2 appears to participate in transducing the signal generated upon binding of @entity5 to @entity7 . However, whether @entity5 signalling would thereby interfere with ligand-driven @entity2 signalling was not described before. Therefore, it was the aim of the present study to investigate the combined effects of @entity5 and EGF in the low invasive and high invasive @entity0 cell lines MCF-7 and MDA-MB-231, respectively. Simultaneous exposure of cells to both signals negatively affected @entity4 and @entity3 activation whereas positive effects on @entity6 and Src kinase phosphorylation were noted in both cell lines. Furthermore, @entity5 attenuated the mitogenic effect of EGF on cellular proliferation, invasion and motility in both MCF-7 and MDA-MB-231 cells. Experiments with the @entity5 amino terminal fragment (ATF) revealed that the negative effects of @entity5 were independent from its protease activity. Together, these data suggest that enhanced levels of @entity5 in @entity0 modulate the mitogenic effects of EGF and thus, this knowledge may help to better understand @entity0 pathogenesis as well as to develop new therapeutic options.    2015 Wiley Periodicals, Inc.

title: Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two XXXX cell lines MCF-7 and MDA-MB-231.

answer: @entity0


abstract: The overall pattern of the mesoderm in the @entity3 of the cranial region of @entity0 embryos was examined with the scanning electron microscope (SEM). A segmental organization was observed first in the paraxial mesodermal wings and midline @entity4 of embryos at the late primitive streak stage. Each segmental unit consists of a somitomere in the paraxial region on each side of an enclosed stretch of midline notochord. Somitomeres appear initially as circular domains of radially arranged cells that swirl about the core center of the unit and are quite similar morphologically to those described recently in @entity2 embryos [12]. Lying in tandem sequence, the segments comprise the chordamesoderm that underlies the neural plate. As additional pairs of somitomeres are added from the primitive streak at the caudal end of the @entity4 , those established in the cranial region remain contiguous and undergo morphogenesis that is coordinate with neurulation. We divide the development of the cranial @entity4 into five phases and associate somitomeres in the mesoderm with @entity1 in the neural plate. It was found that the first pair of somitomeres comes to underlie the prosencephalon, the second and third pairs underlie the mesencephalon, while the fifth, sixth, and seventh pairs of somitomeres underlie neuromeres of the metencephalon. The eighth pair of somitomeres are the first to separate themselves from the first seven and from the first pair of somites visible at the light microscope level. This study suggests that the cranial @entity4 of the @entity0 embryo is initially organized into segments like the rest of the body and that subsequent cranial morphology is a consequence of differential development of these segments.

title: Metameric pattern development in the XXXX of the @entity0 . I. Differentiation of the cranial segments.

answer: @entity3


abstract: The overall pattern of the mesoderm in the @entity3 of the cranial region of @entity0 embryos was examined with the scanning electron microscope (SEM). A segmental organization was observed first in the paraxial mesodermal wings and midline @entity4 of embryos at the late primitive streak stage. Each segmental unit consists of a somitomere in the paraxial region on each side of an enclosed stretch of midline notochord. Somitomeres appear initially as circular domains of radially arranged cells that swirl about the core center of the unit and are quite similar morphologically to those described recently in @entity2 embryos [12]. Lying in tandem sequence, the segments comprise the chordamesoderm that underlies the neural plate. As additional pairs of somitomeres are added from the primitive streak at the caudal end of the @entity4 , those established in the cranial region remain contiguous and undergo morphogenesis that is coordinate with neurulation. We divide the development of the cranial @entity4 into five phases and associate somitomeres in the mesoderm with @entity1 in the neural plate. It was found that the first pair of somitomeres comes to underlie the prosencephalon, the second and third pairs underlie the mesencephalon, while the fifth, sixth, and seventh pairs of somitomeres underlie neuromeres of the metencephalon. The eighth pair of somitomeres are the first to separate themselves from the first seven and from the first pair of somites visible at the light microscope level. This study suggests that the cranial @entity4 of the @entity0 embryo is initially organized into segments like the rest of the body and that subsequent cranial morphology is a consequence of differential development of these segments.

title: Metameric pattern development in the @entity3 of the XXXX . I. Differentiation of the cranial segments.

answer: @entity0


abstract: UNASSIGNED: The 1930 International Labour Office Conference on @entity2 in Johannesburg was a turning point in the history of @entity2 and in the recognition of the associated pathologic patterns. Since 1930, pneumoconioses such as @entity2 have become much rarer in developed countries and can now be diagnosed at an early stage based on clinical and radiologic criteria. However, in spite of these advances, pathologists must remember to look for @entity1 in tissues, particularly when clinical and radiologic findings are more uncertain. Furthermore, nowadays pathologists essentially observe silicotic lesions as incidental findings @entity0 . In addition to identifying the characteristic lesions, pathologists must also try to identify their causative agent, in the case of crystalline @entity1 firstly by using polarized light examination, followed as appropriate by more sophisticated devices. Finally, pathologists and clinicians must always keep in mind the various implications of exposure to @entity1 compounds in a wide range of diseases. Am. J. Ind. Med. 58:S48-S58, 2015.    2015 Wiley Periodicals, Inc.

title: The pathologist's view of XXXX in 1930 and in 2015. The Johannesburg Conference legacy.

answer: @entity2


abstract: PURPOSE: To develop a free-breathing variable @entity3 angle (VFA) balanced steady-state free precession (bSSFP) cardiac cine imaging technique with reduced specific absorption rate (SAR) at 3 Tesla. METHODS: Free-breathing VFA (FB-VFA) images in the @entity2 and four-chamber views were acquired using an optimal VFA scheme, then compared with conventional breath-hold constant @entity3 angle (BH- @entity5 ) acquisitions. Two cardiac MRI experts used a 5-point scale to score images from healthy subjects (N = 10). The left ventricular ejection fraction, end diastolic volume (LVEDV), end systolic volume, @entity1 volume (LVSV), and end diastolic myocardial mass (LVEDM) were determined by manual contour analysis for BH- @entity5 and FB-VFA. A pilot evaluation of FB-VFA was performed in one @entity0 with @entity4 . RESULTS: FB-VFA SAR was 25% lower than BH- @entity5 with similar blood-myocardium contrast. The qualitative FB-VFA score was lower than the BH- @entity5 for the @entity2 (3.1    0.5 versus 4.3    0.8; P < 0.05) and the four-chamber view (3.4    0.4 versus 4.6    0.6; P < 0.05). The LVEDV and the LVSV were 5% and 12% larger (P < 0.05) for FB-VFA compared with BH- @entity5 . There was no difference in LVEDM. CONCLUSION: FB-VFA bSSFP cardiac cine imaging decreased the SAR at 3T with image quality sufficient to perform cardiac functional analysis. Magn Reson Med, 2015.    2015 Wiley Periodicals, Inc.

title: Free-breathing variable XXXX angle balanced SSFP cardiac cine imaging with reduced SAR at 3T.

answer: @entity3


abstract: UNASSIGNED: Losses of chromosomes 9p and 14q are associated with worse outcomes in @entity0 affected by @entity4 ( @entity4 ) and are helpful for prognostic risk stratification. Both chromosomal loci harbor several hot-spot molecular pathways suitable for targeted therapeutic interventions. Intratumor heterogeneity may foster @entity2 adaptation and therapeutic failure. We sought to investigate the presence of losses of the hot spots of chromosomal loci 9p and 14q in primary clear-cell @entity4 and matched metastatic tissues. @entity5 and @entity7 were performed on 7 cases of clear-cell @entity4 with hematogenous tissue @entity1 . Cytogenetic fluorescence in situ hybridization analysis was performed on primary and matched metastatic tissues using specific probes mapping the 9p and the 14q loci. The @entity3 was observed in 85% of both primary clear-cell RCCs and in matched @entity1 ; 14% showed discordance between primary and matched @entity1 showing gains. The @entity3 was observed in 58% of both primary and matched @entity1 . Only 3/7 (42%) did show an equal status of @entity3 . Heterogeneity of the cytogenetic status between metastatic and primary clear-cell RCCs is observed for the @entity3 rather than chromosome 9p. The impact of chromosome 14q cytogenetic status, harboring the @entity6 gene, a major driver for the angiogenenic switch, may drive the efficacy of targeted inhibitors, whereas the @entity3 , harboring other hot-spot genes, seems to be related to the metastatic behavior per se, without cytogenetic modulation. Reprofiling the metastatic tissue, as compared with the @entity2 , in @entity0 affected by metastatic @entity4 could be a novel approach to overcome resistance to VEGF(Rs)-targeting agents.

title: Reprofiling Metastatic Samples for Chromosome 9p and 14q Aberrations as a Strategy to Overcome @entity2 Heterogeneity in XXXX .

answer: @entity4


abstract: UNASSIGNED: Losses of chromosomes 9p and 14q are associated with worse outcomes in @entity0 affected by @entity4 ( @entity4 ) and are helpful for prognostic risk stratification. Both chromosomal loci harbor several hot-spot molecular pathways suitable for targeted therapeutic interventions. Intratumor heterogeneity may foster @entity2 adaptation and therapeutic failure. We sought to investigate the presence of losses of the hot spots of chromosomal loci 9p and 14q in primary clear-cell @entity4 and matched metastatic tissues. @entity5 and @entity7 were performed on 7 cases of clear-cell @entity4 with hematogenous tissue @entity1 . Cytogenetic fluorescence in situ hybridization analysis was performed on primary and matched metastatic tissues using specific probes mapping the 9p and the 14q loci. The @entity3 was observed in 85% of both primary clear-cell RCCs and in matched @entity1 ; 14% showed discordance between primary and matched @entity1 showing gains. The @entity3 was observed in 58% of both primary and matched @entity1 . Only 3/7 (42%) did show an equal status of @entity3 . Heterogeneity of the cytogenetic status between metastatic and primary clear-cell RCCs is observed for the @entity3 rather than chromosome 9p. The impact of chromosome 14q cytogenetic status, harboring the @entity6 gene, a major driver for the angiogenenic switch, may drive the efficacy of targeted inhibitors, whereas the @entity3 , harboring other hot-spot genes, seems to be related to the metastatic behavior per se, without cytogenetic modulation. Reprofiling the metastatic tissue, as compared with the @entity2 , in @entity0 affected by metastatic @entity4 could be a novel approach to overcome resistance to VEGF(Rs)-targeting agents.

title: Reprofiling Metastatic Samples for Chromosome 9p and 14q Aberrations as a Strategy to Overcome XXXX Heterogeneity in @entity4 .

answer: @entity2


abstract: Death directly related to selective coronary arteriography in 5 @entity0 with a history of unstable @entity6 during the period 1975-1985 is reported. Four different cardiologists were involved. A feature common to all the cases was the presence of significant @entity5 of the left mainstem coronary artery (LMCA); 2 @entity0 had haemodynamically important obstruction of a dominant right coronary artery (RCA) ostium, while 2 others had @entity1 in the proximal part of a dominant RCA. The RCA in the last case was angiographically normal and non-dominant. Collateral coronary blood flow was fairly sparse in most cases and in 4 @entity7 of varying degree was present. All @entity0 developed severe @entity3 and @entity9 after arteriography while still in the cardiac catheterization laboratory. Resuscitation efforts were uniformly unsuccessful. Autopsy on 1 @entity0 demonstrated extensive obstructive @entity2 with a massive @entity4 . Cardiac catheterization poses an extremely high risk for this subgroup of @entity0 with @entity2 , as does selective coronary arteriography. The possible role of catheter-provoked @entity8 is suggested; a recently introduced soft-tipped cardiovascular catheter may be more appropriate in this setting.

title: Left mainstem coronary artery XXXX --death after angiography. A report of 5 cases.

answer: @entity5


abstract: UNASSIGNED: Phytases hydrolyze phytate to release inorganic @entity1 , which decreases the requirement for @entity3 in fertilizers for crops and thus reduces environmental pollutants. This study analyzed microbial communities in rhizosphere sediment, collected in September 2012 from Shenzhen Bay, Guangdong, China, using high-throughput pyrosequencing; the results showed that the dominant taxonomic phyla were Chloroflexi, Firmicutes, and Proteobacteria, and the proportion of the beneficial bacteria, Bacillus, was 4.95 %. Twenty-nine culturable, phytase-producing bacteria were isolated, their @entity3 solubilization capacity was analyzed, and they were taxonomically characterized. Their phylogenetic placement was determined using 16S ribosomal RNA (rRNA) gene sequence analysis. The result shows that most of the isolates are members of the order Bacillales, although seven strains of Enterobacteriales, two strains of Pseudomonadales, and one strain of Oceanospirillales were also identified. The phytase gene was cloned from SPC09, @entity4 , which showed the highest @entity3 solubilizing ability among the isolated strains. The gene encoded a primary translation product of 335 @entity2 . A construct including the 1005-nt ORF fragment, Bc-phy, was transformed into @entity0 . The recombinant phytase was produced and purified, which revealed the temperature optima at 60   C and pH optima at 6.5. The assessment by quantitative PCR (qPCR) showed an abundance of bacteria containing the Bc-phy gene; the level was generally higher in the mangrove forest than in the tidal flats and in surface soil compared to bottom soil, and the highest value was obtained in June. Herein, we report on the cloning, characterization, and activity of a novel phytase isolated from a mangrove system.

title: Microbial diversity of mangrove sediment in Shenzhen Bay and gene cloning, characterization of an isolated phytase-producing strain of SPC09 XXXX .

answer: @entity4


abstract: The teratogenic potential of 2 structurally related dopaminergic agonists, @entity4 ( @entity4 : Chemical Abstracts No. 59257-18-0) and @entity5 ( @entity5 : Chemical Abstracts No. 59257-24-8), has been investigated in pregnant @entity0 . These compounds were administered orally from Days 6 to 15 of gestation inclusive at dose levels of 10, 20 and 40 mg/kg/day for @entity4 and 10, 20 and 35 mg/kg/day for @entity5 . At caesarean section on Day 21 of gestation increased post-implantation loss, reduced foetal weights and high incidences of gross abnormalities were found with both compounds at their high dose levels. @entity1 was evident at the intermediate and high dose levels but teratogenic effects extended to the low dose of each compound where treatment was well tolerated by the dams. The maternal effects were thought to be due to the @entity2 potentiating properties of @entity4 and @entity5 . When @entity3 , a specific @entity2 antagonist, was co-administered with @entity5 the maternal effects were considerably reduced and, although teratogenicity remained, effects of @entity5 on the embryo were extensively modified. This suggests that at least certain of the abnormalities were associated with prolonged @entity2 potentiation. @entity3 alone was not teratogenic.

title: Teratogenicity in XXXX of two dopaminergic agonists.

answer: @entity0


abstract: Malignancies developed in 141 organ transplant recipients treated with @entity2 . The @entity1 showed important differences from those seen following @entity7 ( @entity7 ). They appeared an average of 20 months after @entity2 and 60 months after @entity7 . @entity5 ( @entity5 ) were the most common @entity1 , being 41% compared with 12% in @entity7 @entity0 . They appeared an average of 11 months after transplantation compared with an average of 42 months after @entity7 . Unlike @entity7 @entity0 they more often involved lymph nodes, more frequently involved the small intestine, rarely involved the brain, and were more likely to regress after reduction of immunosuppressive therapy. @entity4 (15% of @entity1 ) were much less common than in @entity7 @entity0 (40%). @entity6 were more common (8% vs. 3%). In this small series there was a surprising @entity8 and @entity3 . Only 8 @entity0 (6%) were treated with @entity2 exclusively. The @entity1 probably are not specific to @entity2 therapy but appear to be a complication of immunosuppression per se.

title: @entity1 following XXXX therapy.

answer: @entity2


abstract: Malignancies developed in 141 organ transplant recipients treated with @entity2 . The @entity1 showed important differences from those seen following @entity7 ( @entity7 ). They appeared an average of 20 months after @entity2 and 60 months after @entity7 . @entity5 ( @entity5 ) were the most common @entity1 , being 41% compared with 12% in @entity7 @entity0 . They appeared an average of 11 months after transplantation compared with an average of 42 months after @entity7 . Unlike @entity7 @entity0 they more often involved lymph nodes, more frequently involved the small intestine, rarely involved the brain, and were more likely to regress after reduction of immunosuppressive therapy. @entity4 (15% of @entity1 ) were much less common than in @entity7 @entity0 (40%). @entity6 were more common (8% vs. 3%). In this small series there was a surprising @entity8 and @entity3 . Only 8 @entity0 (6%) were treated with @entity2 exclusively. The @entity1 probably are not specific to @entity2 therapy but appear to be a complication of immunosuppression per se.

title: XXXX following @entity2 therapy.

answer: @entity1


abstract: PROBLEM: To determine the understudied relationship between complement Bb during pregnancy in subjects with @entity1 compared with normotensive controls. METHOD OF STUDY: Nested case-control study. RESULTS: Average Bb levels significantly decreased over time in pregnancy [ @entity2 (S.E.): -0.0094 (0.0005), P < 0.01]. Cross-sectionally, at less than 10 weeks, Bb levels decreased with increasing gestational age in @entity0 who remained normotensive [ @entity2 (S.E.): -0.007 (0.02) and for @entity0 who developed @entity1 ( @entity2 (S.E.): -0.059 (0.03) P = 0.12]. Among @entity0 who developed @entity1 , Bb levels were greatest when samples were drawn in the gestational window of 15-20 weeks [( @entity2 (S.E.): 0.06 (0.02)], while levels among normotensive @entity0 were inversely related with gestational age [ @entity2 (S.E.): -0.02 (0.01)]. The differences in slopes between cases and controls between 10 and 21 weeks' gestation were statistically significant (P = 0.003). CONCLUSIONS: We suggest dysregulation of Bb activation between 10 and 20 weeks' gestation in @entity0 who develop @entity1 .

title: The Relationship of Longitudinal Levels of Complement Bb During Pregnancy with XXXX .

answer: @entity1


abstract: BACKGROUND: Preventing @entity2 during pregnancy is important for the health of mothers and newborns. Interventions, which include distribution of bed nets and administration of intermittent preventive treatment (IPT), typically occur at the first antenatal visit, usually in the second or third trimester of pregnancy. In 2012, during the course of ongoing clinical studies of @entity2 among pregnant @entity0 in Malawi, a universal bed net campaign was implemented by the Government. This study tested the hypothesis that a universal bed net campaign would decrease the prevalence of @entity2 among pregnant @entity0 at their first antenatal visit. METHODS: Some 1661 @entity0 were recruited for two studies from 2009 to 2014. Quantitative PCR (qPCR) was conducted from dried blood spots collected at the first antenatal care visit (prior to administration of IPT or any study interventions) from @entity0 who were in their first or second pregnancy and less than 28  weeks gestation by clinical assessment. RESULTS: Overall, 320 of 1629 (19.6  %) @entity0 tested for @entity2 at their first antenatal visit were infected. @entity1 rates declined from 28.4  % before the universal bed net campaign, to 18.5  % in 2012, to 15.0  % in the years following the universal bed net campaign. The odds of @entity1 at the time of first antenatal visit in 2012 and the years following the bed net campaign were significantly lower than in the years prior to the intervention (OR 0.6, 95  % CI 0.4-0.8; and OR 0.4, 95  % CI 0.3-0.6, respectively). A similar pattern was observed for the prevalence of clinical @entity2 . The inverse trend was observed for reported bed net use. However bed net use and @entity1 were not significantly associated on the individual level. CONCLUSIONS: @entity1 in pregnant @entity0 is common even after a bed net campaign in Malawi, though prevalence rates declined. These early infections may cause maternal @entity3 and placental @entity2 resulting in adverse maternal and fetal outcomes. Infection early in pregnancy may also contribute to @entity2 transmission as pregnant @entity0 represent a significant untreated reservoir of parasites. Universal bed net distribution appears to have moderate success in preventing @entity2 early in pregnancy and these findings support continued efforts to target @entity0 early in pregnancy and all @entity0 of childbearing age.

title: The prevalence of XXXX at first antenatal visit in Blantyre, Malawi declined following a universal bed net campaign.

answer: @entity2