abstract: OBJECTIVES: To compare @entity3 ( @entity3 ) movement and leading-edge-of-the-bolus location patterns of sequential swallowing in @entity0 with @entity1 and healthy adults, and to determine whether these patterns affect swallowing safety. DESIGN: Between-groups comparison. SETTING: Veterans hospital. @entity0 : Consecutively admitted @entity0 with acute unilateral @entity1 (right hemisphere damage, n=13; left hemisphere damage, n=16) and age-matched healthy @entity0 (n=25). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: @entity3 movement pattern, bolus location, Penetration-Aspiration (P-A) Scale score. RESULTS: No significant group differences were observed for @entity3 movement pattern, bolus location, and P-A Scale score. Specific @entity3 movement patterns and bolus location were not associated with a higher P-A Scale score. A significant correlation between @entity3 movement pattern and bolus location was observed. Bolus location was typically inferior to the valleculae between swallows when the @entity3 was partially elevated. Across all groups, P-A Scale scores were significantly higher during sequential swallowing than single swallows. CONCLUSIONS: @entity3 movement pattern and bolus location do not appear related to airway invasion, at least in @entity0 without significant @entity2 . Given higher P-A Scale scores during sequential swallowing as compared with single swallows, sequential swallowing should always be evaluated in all @entity0 .

title: Comparison of sequential swallowing in @entity0 with XXXX and healthy adults.

answer: @entity1


abstract: OBJECTIVES: To compare @entity3 ( @entity3 ) movement and leading-edge-of-the-bolus location patterns of sequential swallowing in @entity0 with @entity1 and healthy adults, and to determine whether these patterns affect swallowing safety. DESIGN: Between-groups comparison. SETTING: Veterans hospital. @entity0 : Consecutively admitted @entity0 with acute unilateral @entity1 (right hemisphere damage, n=13; left hemisphere damage, n=16) and age-matched healthy @entity0 (n=25). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: @entity3 movement pattern, bolus location, Penetration-Aspiration (P-A) Scale score. RESULTS: No significant group differences were observed for @entity3 movement pattern, bolus location, and P-A Scale score. Specific @entity3 movement patterns and bolus location were not associated with a higher P-A Scale score. A significant correlation between @entity3 movement pattern and bolus location was observed. Bolus location was typically inferior to the valleculae between swallows when the @entity3 was partially elevated. Across all groups, P-A Scale scores were significantly higher during sequential swallowing than single swallows. CONCLUSIONS: @entity3 movement pattern and bolus location do not appear related to airway invasion, at least in @entity0 without significant @entity2 . Given higher P-A Scale scores during sequential swallowing as compared with single swallows, sequential swallowing should always be evaluated in all @entity0 .

title: Comparison of sequential swallowing in XXXX with @entity1 and healthy adults.

answer: @entity0


abstract: OBJECTIVES: To compare 2 methods for determining neglect in @entity0 within 2 days of @entity1 , and to investigate whether early neglect was related to rehabilitation practice, and whether this relationship was affected by an early, intensive mobilization intervention. DESIGN: Data were collected from @entity0 participating in a phase II randomized controlled trial of early rehabilitation after @entity1 . SETTING: Acute @entity1 unit. @entity0 : @entity1 @entity0 (N=71). INTERVENTION: The 2 arms of the trial were very early mobilization (VEM) and standard care (SC). MAIN OUTCOME MEASURES: Neglect was assessed using the Star Cancellation Test and the National Institutes of Health @entity1 Scale (NIHSS) inattention item within 48 hours of @entity1 onset, and therapy details were recorded during the hospital stay. RESULTS: Assessing neglect so acutely after @entity1 was difficult: 29 of the 71 @entity0 were unable to complete the Star Cancellation Test, and agreement between this test and the NIHSS measure was only .42. Presence of neglect did not preclude early mobilization. SC group @entity0 with neglect had longer hospital stays (median, 11d) than those without neglect (median, 4d); there was no difference in length of stay between @entity0 with and without neglect in the VEM group (median, 6d in both). CONCLUSION: Early mobilization of @entity0 with neglect was feasible and may contribute to a shorter acute hospital stay.

title: Hemispatial neglect and rehabilitation in acute XXXX .

answer: @entity1


abstract: The AOK Baden-W  rttemberg health insurance fund initiated a study on the outpatient rehabilitation of @entity0 with @entity3 , aimed at improving the treatment concept for its insurees with @entity3 (START). This model project was scientifically guided by the Hochrhein-Institute in Bad S  ckingen. The paper compares the effectiveness of Enhanced Outpatient Physiotherapy (Erweiterte Ambulante Physiotherapie, @entity5 ), Outpatient Rehabilitation (Ambulante Rehabilitation, AR) and Medical Training Therapy (Medizinische Trainingstherapie, @entity1 ) in @entity0 with @entity3 . In seven regions in Baden-W  rttemberg, one of these three intervention forms was provided to the @entity0 . A total of 1,274 @entity0 were included in the study. The AOK Baden-W  rttemberg @entity0 receiving treatment in one of the three intervention forms were seriously restricted in both the physical dimension of their health status and in their physical mobility in everyday life and at the workplace. Besides, they frequently reported considerable @entity4 . The three interventions led to significant and relevant decreases in @entity2 intensity and to an improved health-related quality of life. There were no significant differences between the various treatments in terms of effectiveness. The @entity0 shared an equally high satisfaction with the treatment received. In @entity1 , the total therapy length of 15 weeks was by far longer than in AR and @entity5 (about 5 and 8 weeks). Unlike AR and, in parts, @entity5 , @entity0 may continue to work while participating in @entity1 . Therefore an immediate therapy start within a week was more likely possible in @entity1 (59 %) than in AR (10 %) or @entity5 (23 %). In evaluating the results a number of restrictions have to be considered. Nevertheless, based on our research findings, the following can be concluded: @entity1 is a suitable therapy concept in @entity0 with @entity3 characterized by a rapid start and-- compared to the other two concepts-- by lower therapy costs. @entity1 might represent a meaningful therapy element also in new forms of provision such as integrated services. @entity0 showing severe @entity4 should be assigned to an interdisciplinary therapy as it is provided by inpatient and outpatient rehabilitation facilities. For effective differential assignment to the various programmes, realization of a standardized rehab assessment is an important precondition.

title: [Comparison of three outpatient therapy forms for treatment of XXXX -- findings of a multicentre, cluster randomized study].

answer: @entity3


abstract: BACKGROUND: Veterans of Operations Enduring Freedom and Iraqi Freedom ( @entity3 ) have endured high combat stress and are eligible for 2 years of free military service-related health care through the Department of Veterans Affairs (VA) health care system, yet little is known about the burden and clinical circumstances of mental health diagnoses among @entity3 veterans seen at VA facilities. METHODS: US veterans separated from @entity3 military service and first seen at VA health care facilities between September 30, 2001 (US invasion of Afghanistan), and September 30, 2005, were included. Mental health diagnoses and psychosocial problems were assessed using International Classification of Diseases, Ninth Revision, Clinical Modification codes. The prevalence and clinical circumstances of and subgroups at greatest risk for @entity0 are described herein. RESULTS: Of 103 788 @entity3 veterans seen at VA health care facilities, 25 658 (25%) received mental health diagnosis(es); 56% of whom had 2 or more distinct mental health diagnoses. Overall, 32 010 (31%) received mental health and/or psychosocial diagnoses. Mental health diagnoses were detected soon after the first VA clinic visit (median of 13 days), and most initial mental health diagnoses (60%) were made in nonmental health clinics, mostly primary care settings. The youngest group of @entity3 veterans (age, 18-24 years) were at greatest risk for receiving mental health or @entity1 diagnoses compared with veterans 40 years or older. CONCLUSIONS: Co-occurring mental health diagnoses and psychosocial problems were detected early and in primary care medical settings in a substantial proportion of @entity3 veterans seen at VA facilities. Targeted early detection and intervention beginning in primary care settings are needed to prevent chronic @entity2 and disability.

title: Bringing the war back home: XXXX among 103,788 US veterans returning from Iraq and Afghanistan seen at Department of Veterans Affairs facilities.

answer: @entity0


abstract: OBJECTIVE: To study the therapeutic method and clinical effect of domestic locking plate for treating @entity2 of the tubiform bone through a minimal incision and bridging fixation. METHODS: Among 40 @entity0 with @entity2 of the tubiform bone, 29 @entity0 were male and 11 @entity0 were female, aged from 29 to 69 years, with the average of 38.27 years. Among 34 @entity0 with closed @entity2 , 7 cases were type A, 10 cases type B, 17 cases type C according to AO/ASIF classification. Among 6 @entity0 with open @entity2 , 2 cases were type I, 4 cases were type II according to Gustilo classification. These @entity0 were treated with a small incision after manipulative reduction. Locking plate and 3.5 mm diameter Kirschner wire were used to maintain the reduction and through the C-arm X-ray machine to check and adjust the position, screw were locked to bridging fixation at last. RESULTS: Forty cases were followed up in 6 months on average (ranging from 4 to 10 months). The average time of union of @entity2 was 4.6 months (ranging from 3 to 8 months). According to Ovadia typing, the results were excellent in 16 cases, good in 20 cases, fair in 3 cases,poor in 1 case. The excellent and good rate was 90%. CONCLUSIONS: The domestic locking plate is suitable for @entity0 with @entity1 and @entity3 because of the advantages of reliable fixation and low price. It could achieve the same effect of minimal invasive as LISS (less invasive stabilizing system) plate through the improvement of operative method.

title: [Treatment of XXXX of the tubiform bone with domestic locking plate through minimal invasive incision and bridging reduction fixation].

answer: @entity2


abstract: OBJECTIVE: To evaluate the outcome and indication of surface-replacement total hip arthroplasty in the treatment of the @entity3 . METHODS: The clinical data of 17 @entity0 (21 hips) with @entity3 were reviewed. Among which, 10 cases were male and 7 cases were female, the average age was 36 years old (ranging from 25 to 51 years). There were 8 hips at Ficat stage III and 10 hips at Ficat stage IV. The 17 @entity0 (21 hips) underwent surface-replacement total hip arthroplasty. Gibson posterolateral incision was used and non-cemented prosthesis was implanted. For prosthetic femoral head fixation, a guide pin was inserted into the capital center. After hollow boring hit drilling, a guide pole was inserted, and redundancy of femoral head was rasped off with cutterbar. The bone cement was painted on the femoral head and prosthesis, and the prosthesis was planted into the central axis hole of neck of femur until bone cement solidification. The therapeutic effects were evaluated by Harris hip score and statistical analysis was made. The X-ray was rechecked regularly. RESULTS: The mean duration of follow-up was 32 months (18 to 42 months). The average Harris hip score was improved significantly from preoperative 35.30 +/- 5.23 to postoperative 90.47 +/- 3.14, and the excellent and good rate was 90.5%. There were high statistical differences between preoperative and postoperative Harris score (P < 0.01). The X-ray showed radiolucent line around acetabular prostheses in two @entity0 but without prostheses loosening. CONCLUSION: Surface-replacement total hip arthroplasty is a satisfactory way for the treatment of @entity3 in the middle-late phase, which can help reconstructing normal joint biomechanics and load transmission,improving joint stability and postponing @entity2 without affecting later rebuilding, as well as some advantages such as decreasing surgical wound, convenient and low infection rate. Its indication is Ficat stage III and part Ficat stage IV femur @entity1 with less destroyed neck of femur,especially for young @entity0 having a large amount of activity.

title: [Surface-replacement total hip arthroplasty in the treatment of the XXXX ].

answer: @entity3


abstract: BACKGROUND/AIMS: Although essential for postoperative recovery, excessive surgical stress response leads to higher rate of serious postoperative complications, such as @entity1 and @entity3 . Exact regulation of surgical stress response is not yet known. Still, our ability to modify surgical stress response severity has led to diminished postoperative morbidity and mortality rates and development of fast-track surgery. In this study we tried to further clarify the roles of several cytokines in surgical stress response regulation. METHODOLOGY: We measured leukocyte count and serum concentrations of @entity10 , @entity9 , @entity6 , @entity7 , @entity2 , @entity5 and @entity8 in @entity0 undergoing gastrectomy or gastric resection for @entity4 . Blood samples were collected preoperatively, 3 hours, 24 hours and 48 hours postoperatively. We also grouped our @entity0 according to operation type and duration and then compared measured values between groups. RESULTS: Elevated postoperative leukocyte count and serum concentrations of @entity11 , @entity6 , @entity7 and @entity8 were measured, all peaking at 3 hours postoperatively. Also, serum @entity6 concentration was higher after longer operations, and leukocyte count was higher after gastrectomy. CONCLUSIONS: The synchronicity of postoperative elevation of @entity11 , @entity6 and @entity7 concentrations, each having different role in surgical stress response regulation, might indicate that, in order to determine surgical stress response severity, several cytokines should be measured simultaneously.

title: Serum cytokine changes after gastric resection or gastrectomy for XXXX .

answer: @entity4


abstract: BACKGROUND AND OBJECTIVE: The objectives of the present study were to evaluate the relationships between the results of the cuff-leak test and the presence of @entity1 ; to assess whether lesions needing pharmacological treatment and surveillance can be predicted by the cuff-leak test; and to analyse the relationships between these lesions and postextubation stridor. METHODS: The present study is a preliminary, prospective, clinical investigation set in an 11-bed ICU of a university hospital. We studied 50 consecutive adult @entity0 admitted to the ICU and mechanically ventilated for more than 72 h. All @entity0 underwent cuff-leak test before extubation. A laryngoscopic inspection was performed after extubation to evaluate the presence and degrees of @entity1 . @entity1 were classified according to a 5-degree scale (0-4); @entity0 with clinical manifestations were pharmacologically treated and monitored. RESULTS: A threshold cuff-leak value of 0.07 l (21% of tidal volume) was determined by visual inspection of the receiver-operating characteristic plot. @entity0 were divided into a positive and a negative cuff-leak test group. Comparing the severity of @entity1 to the cuff-leak test, a relationship between higher degrees of lesions (degrees 3-4) and the positivity of the cuff-leak test (31.3% in the positive cuff-leak test group vs. 3.8% in the negative cuff-leak test group; P = 0.023) was observed. The positive and the negative predictive values were 25 and 96.1%, respectively. Only two cases of postextubation stridor were found, one in each group. There was no correlation between the results of the cuff-leak test and the occurrence of postextubation acute respiratory difficulties. CONCLUSION: Cuff-leak test is a simple, noninvasive tool, which may be useful to exclude, in @entity0 with prolonged intubations, the presence of laryngeal injuries needing medical treatment and close monitoring. This occurs independently of postextubation stridor.

title: Cuff-leak test predicts the severity of postextubation acute XXXX : a preliminary study.

answer: @entity1


abstract: OBJECTIVE: To evaluate the safety and efficacy of a new low profile balloon septostomy catheter in neonatal animals as well as in one newborn @entity0 . BACKGROUND: Balloon @entity3 remains one of the most commonly performed palliative procedures in pediatric cardiology. The currently available septostomy catheter requires a large introducer sheath (6 or 7F), does not have an end hole for confirmation of position or pressure measurement and is limited in @entity0 with a small left atrium due to its large balloon inflated diameter. METHODS: Four neonatal piglets (average weight 3.9 kg) underwent percutaneous balloon @entity3 using the new balloon catheter inflated to 1 cc via a 5F sheath in the femoral vein. Two other piglets (average weight 4.9 kg) underwent septostomy with the conventional catheter inflated to 3.5 cc via a 6 or 7F sheath in the femoral vein. All animals underwent transthoracic echocardiography pre and post septostomy. All animals were sacrificed after the procedure and the size of the @entity1 created was measured. One neonate with @entity4 underwent septostomy with the new balloon catheter. RESULTS: The left atrium was entered in all piglets. It was easier to enter the left atrium with an end hole catheter which was exchanged over a wire with the septostomy catheter. Septostomy was performed with the new or conventional catheters without complications. Echocardiography demonstrated a very small patent foramen ovale prior to the procedure and a large @entity1 after septostomy. The average size of the defect created by the new catheter was 11.3 x 10 mm in diameter and 11 x 10 mm using the conventional catheter. A 10 x 10 mm atrial communication was created in the neonate. CONCLUSIONS: This study demonstrates the safety and efficacy of this new catheter. This catheter will be of potential importance in @entity0 with a small left atrium and in small neonates with @entity2 requiring septostomy.

title: A new low profile balloon XXXX catheter: initial animal and clinical experience.

answer: @entity3


abstract: OBJECTIVE: To investigate whether amateur golfers with self-reported @entity2 have reduced @entity1 compared to asymptomatic controls. DESIGN: Observational case-control study. SETTING: Data collection took place at 2 amateur golf clubs in southern England. @entity0 : On initial contact, all @entity0 completed a screening questionnaire used to allocate @entity0 into @entity3 (n=28) and control groups (n=36). @entity3 group were found to be heavier than controls (t=2.242, 95% CI 0.763-13.332) but were matched for age, height, handedness, handicap, rounds played per week and years of play. MAIN OUTCOME MEASURES: Primary outcome measures were lead and non-lead hip medial and lateral rotation in 0 degrees of flexion as measured by inclinometer. Secondary measures included inter and intra-rater reliability. RESULTS: The @entity3 group had significantly reduced lead hip passive ( @entity3 21.14+/-10.17 degrees; controls 31.06+/-8.06 degrees, t=-4.228, 95% CI -14.621--5.205) and lead hip active medial rotation ( @entity3 21.46+/-10.01; controls 28.06+/-7.49 degrees, t=-2.908, 95% CI -11.147--2.036) compared to controls. No between group differences were found in non-lead hips or any passive or active lateral rotation measures. CONCLUSION: Although there is lack of causality between @entity3 and @entity1 , the deficit in lead leg medial @entity1 in amateur golfers who suffer @entity3 may be relevant for screening or treatment selection.

title: The relationship between @entity1 and XXXX prevalence in amateur golfers: an observational study.

answer: @entity2


abstract: OBJECTIVE: To investigate whether amateur golfers with self-reported @entity2 have reduced @entity1 compared to asymptomatic controls. DESIGN: Observational case-control study. SETTING: Data collection took place at 2 amateur golf clubs in southern England. @entity0 : On initial contact, all @entity0 completed a screening questionnaire used to allocate @entity0 into @entity3 (n=28) and control groups (n=36). @entity3 group were found to be heavier than controls (t=2.242, 95% CI 0.763-13.332) but were matched for age, height, handedness, handicap, rounds played per week and years of play. MAIN OUTCOME MEASURES: Primary outcome measures were lead and non-lead hip medial and lateral rotation in 0 degrees of flexion as measured by inclinometer. Secondary measures included inter and intra-rater reliability. RESULTS: The @entity3 group had significantly reduced lead hip passive ( @entity3 21.14+/-10.17 degrees; controls 31.06+/-8.06 degrees, t=-4.228, 95% CI -14.621--5.205) and lead hip active medial rotation ( @entity3 21.46+/-10.01; controls 28.06+/-7.49 degrees, t=-2.908, 95% CI -11.147--2.036) compared to controls. No between group differences were found in non-lead hips or any passive or active lateral rotation measures. CONCLUSION: Although there is lack of causality between @entity3 and @entity1 , the deficit in lead leg medial @entity1 in amateur golfers who suffer @entity3 may be relevant for screening or treatment selection.

title: The relationship between XXXX and @entity2 prevalence in amateur golfers: an observational study.

answer: @entity1


abstract: @entity4 is a modified form of @entity0 placental glucocerebrosidase used as enzyme replacement therapy for @entity0 with @entity3 , in whom functional glucocerebrosidase is deficient. @entity4 has provided a breakthrough in treatment for @entity0 with this relatively rare disease. With @entity4 infusions typical disease manifestations are ameliorated or normalised: @entity2 is reduced, haematological parameters improve, and @entity0 experience an increased quality of life usually within 4 to 6 months of treatment. Parameters of @entity1 also respond, but generally over a longer period of treatment. @entity4 is well tolerated by @entity0 and adults, with few adverse effects reported. Seroconversion occurs in approximately 15% of @entity0 on high-dose therapy, but does not appear to affect the efficacy of treatment. Several dosage regimens have been used to deliver @entity4 , and the comparative benefits of these remain controversial. High-dose regimens of 60 IU/kg bodyweight administered every 2 weeks are clearly effective; however, smaller dosages given more frequently are also effective and incur a greatly reduced acquisition cost. @entity0 responses are variable, and the dosage regimen should be tailored to individual needs. Dosage regimens may be considerably reduced for the maintenance phase of treatment, but clinical experience is as yet insufficient to establish the minimum dosages required in the long term. Acquisition cost of @entity4 is  US3.70 per unit (1994 US dollars); thus, a dosage regimen of 60 IU/kg bodyweight administered every 2 weeks for a @entity0 weighing 70kg costs  US404,040 per year. The minimal costs per quality-adjusted life year saved (QALY) have been estimated for 3 dosage regimens over a 10-year period. Cost per QALY was  US147,000 for 60 IU/kg bodyweight administered every 2 weeks,  US75,000 for 30 IU/kg every 2 weeks, and  US49,000 for 2.3 IU/kg administered 3 times per week. These costs were calculated assuming immediate death with no treatment, which suggests that the actual costs per QALY for most @entity0 with type 1 or 3 disease are likely to be much higher. Drug administration costs may become a significant part of the cost during maintenance therapy; in addition, possible cost savings due to increased @entity0 productivity and reduced palliative treatments remain unresolved. Although some @entity0 may obtain increased benefit from high-dosage regimens, the very high cost may preclude general use of these regimens. Healthcare resources consumed by @entity4 therapy represent a large opportunity cost for other therapeutic areas.(ABSTRACT TRUNCATED AT 400 WORDS)

title: @entity4 . A pharmacoeconomic appraisal of its use in the treatment of XXXX .

answer: @entity3


abstract: @entity4 is a modified form of @entity0 placental glucocerebrosidase used as enzyme replacement therapy for @entity0 with @entity3 , in whom functional glucocerebrosidase is deficient. @entity4 has provided a breakthrough in treatment for @entity0 with this relatively rare disease. With @entity4 infusions typical disease manifestations are ameliorated or normalised: @entity2 is reduced, haematological parameters improve, and @entity0 experience an increased quality of life usually within 4 to 6 months of treatment. Parameters of @entity1 also respond, but generally over a longer period of treatment. @entity4 is well tolerated by @entity0 and adults, with few adverse effects reported. Seroconversion occurs in approximately 15% of @entity0 on high-dose therapy, but does not appear to affect the efficacy of treatment. Several dosage regimens have been used to deliver @entity4 , and the comparative benefits of these remain controversial. High-dose regimens of 60 IU/kg bodyweight administered every 2 weeks are clearly effective; however, smaller dosages given more frequently are also effective and incur a greatly reduced acquisition cost. @entity0 responses are variable, and the dosage regimen should be tailored to individual needs. Dosage regimens may be considerably reduced for the maintenance phase of treatment, but clinical experience is as yet insufficient to establish the minimum dosages required in the long term. Acquisition cost of @entity4 is  US3.70 per unit (1994 US dollars); thus, a dosage regimen of 60 IU/kg bodyweight administered every 2 weeks for a @entity0 weighing 70kg costs  US404,040 per year. The minimal costs per quality-adjusted life year saved (QALY) have been estimated for 3 dosage regimens over a 10-year period. Cost per QALY was  US147,000 for 60 IU/kg bodyweight administered every 2 weeks,  US75,000 for 30 IU/kg every 2 weeks, and  US49,000 for 2.3 IU/kg administered 3 times per week. These costs were calculated assuming immediate death with no treatment, which suggests that the actual costs per QALY for most @entity0 with type 1 or 3 disease are likely to be much higher. Drug administration costs may become a significant part of the cost during maintenance therapy; in addition, possible cost savings due to increased @entity0 productivity and reduced palliative treatments remain unresolved. Although some @entity0 may obtain increased benefit from high-dosage regimens, the very high cost may preclude general use of these regimens. Healthcare resources consumed by @entity4 therapy represent a large opportunity cost for other therapeutic areas.(ABSTRACT TRUNCATED AT 400 WORDS)

title: XXXX . A pharmacoeconomic appraisal of its use in the treatment of @entity3 .

answer: @entity4


abstract: BACKGROUND: Coiling of @entity1 with @entity3 coils sometimes results in relatively poor angiographic results which may be is related to low packing volumes achieved. Hydrogel coated expandable coils (HydroCoil) have been shown to achieve better @entity2 volume filling which may potentially result in lower recanalization rates. Currently there is limited clinical data on their safety and efficacy in @entity2 treatment. METHODS: We analyzed data from a prospectively collected database on @entity0 treated at the Toronto Western Hospital. The analysis included the @entity0 ' characteristics, @entity2 size, packing, procedure related complications, recanalization and clinical outcome. RESULTS: Twenty-nine @entity2 were treated with HydroCoils only or in combination with other coils. The average calculated filling of the @entity2 volume was 74-76%. On the immediate post treatment angiograms, 44% of the @entity2 were completely obliterated, 33% had a residual neck and, in 20%, a residual @entity2 was seen. Follow-up imaging was available in 23 cases. On imaging follow-up (from 2 days to 11 months) one dissecting @entity2 had recanalized. There were six technical/medical complications with no clinical consequences. Two clinically significant procedural related complications occurred. CONCLUSIONS: HydroCoils can be used effectively to treat @entity1 . The volume expansion allows for much greater packing than described for bare @entity3 coils, which may result in better long-term results. The recanalization rate is low but the limited follow-up does not allow for any conclusion regarding the long-term outcome. The complication rate is similar to larger current series using bare @entity3 coils.

title: Treatment of XXXX with hydrogel coated expandable coils.

answer: @entity1


abstract: PURPOSE: The objective of this work was the study of in vivo dosimetry performed in a series of 54 @entity0 receiving @entity1 ( @entity1 ) at the Salah-Azaiz Institute of Tunis since 2004. In vivo dosimetry measurements were compared to analytically calculated doses from monitor units delivered. @entity0 AND METHOD: The irradiation was conducted by a linear accelerator (Clinac 1800, Varian, Palo Alto, USA) using nominal X-rays energies of 6 MV and 18 MV, depending on the thickness of the @entity0 at the abdomen. The dose was measured by semi-conductors p-type EPD-20. These diodes were calibrated in advance with an ionization chamber "PTW Farmer" type of 0.6cm(3) and were placed on the surface of plexiglas phantom in the same @entity1 conditions. A study of dosimetric characteristics of semi-conductors EPD-20 was carried out as a function of beam direction and temperature. Afterwards, we conducted a comparative analysis of doses measured using these detectors during irradiation to those calculated retrospectively from monitor units delivered to each @entity0 conditioned by @entity1 . RESULTS: Experience showed that semi-conductors are sensitive to the angle of beam radiation (0-90 degrees ) and the temperature (22-40 degrees C). The maximum variation is respectively 5 and 7%, but in our irradiation conditions these correction factors are less than 1%. The analysis of the results of the in vivo dosimetry had shown that the ratio of the average measured doses and analytically calculated doses at the abdomen, mediastina, right lung and head are 1.005, 1.007, 1.0135 and 1.008 with a standard deviation "type A" respectively of 3.04, 2.37, 7.09 et 4.15%. CONCLUSION: In vivo dosimetry by semi-conductors is in perfect agreement with dosimetry by calculation. However, in vivo dosimetry using semiconductors is the only technique that can reflect the dose actually received instantly by the @entity0 during @entity1 given the many factors that calculation can not take into account: @entity0 and organs motions and the heterogeneity of the targets.

title: [In vivo dosimetry study of semi-conductors EPD-20 in XXXX technique].

answer: @entity1


abstract: We have shown that expiratory flows increase when expirations are rapidly interrupted in stable @entity2 @entity0 . We hypothesized that a similar increase could be obtained in @entity0 with acute exacerbation of @entity1 treated in the Emergency Room. A total of 30 @entity2 @entity0 were randomly allocated into two groups, the study and the control groups. @entity0 in the study group were connected to a device with an inspiratory line designed to administer pressurized aerosols. The expiratory line passed through a valve completely interrupting flow at 4 Hz, with an open/closed time ratio of 10/3. The control group @entity0 were also connected to the device, but with the valve kept open. Mean expiratory flow at tidal volume (MEFTV) was measured under basal conditions and at 4, 8 and 12 minutes after connecting the @entity0 to the device. All @entity0 received standard treatment throughout the procedure. At all time points MEFTV increased more in the study than in the control group (p < 0.003 by two-way ANOVA). There was no residual effect after disconnection from the device. We conclude that TEFI can rapidly improve expiratory flows in @entity0 with acute exacerbations of @entity1 , while pharmacologic interventions proceed.

title: Transient expiratory flow interruptions (TEFI) increase expiratory flow in acute XXXX exacerbation.

answer: @entity1


abstract: Claudins are integral membrane proteins of the tight junction structures expressed by epithelial and endothelial cells. The present study has evaluated the expression of @entity9 in 10 normal @entity2 hepatoid glands and in 67 hepatoid glands with @entity8 and @entity4 . The lesions studied included normal hepatoid glands (n = 10), @entity7 (n = 10), @entity3 (n = 12), @entity1 (n = 15), @entity1 (n = 15) and @entity1 (n = 15). There was an intensive expression of @entity9 in normal @entity2 hepatoid glands as well as in @entity6 and @entity3 . @entity9 was detected as a well-localised linear circumferential membranous staining pattern of epithelial cells (mature hepatoid cells) in normal hepatoid glands, @entity6 and @entity3 . In @entity7 and @entity3 , the reserve cells showed membrane positivity for the @entity9 molecule. There was a weaker expression in @entity1 . In the @entity1 , the basaloid reserve cells never expressed the @entity9 molecule. The multiple small parts of @entity1 in which the cells exhibited typical hepatoid features showed a well-localised linear circumferential membranous staining pattern for @entity9 . The numerical score for cellular expression of @entity9 was higher in @entity1 than in @entity1 , but moderately lower than in @entity3 . The anaplastic, poorly differentiated @entity1 showed an overexpression of @entity9 . These results suggest that low @entity9 expression in @entity1 is a molecular characteristic indicative of increasing cellular disorientation, @entity5 and invasion by @entity0 cells, and @entity9 seems to be helpful in distinguishing @entity1 from @entity1 and @entity1 of the hepatoid gland. In addition, @entity9 can help distinguish @entity1 from @entity1 of the @entity2 hepatoid gland.

title: Expression of the XXXX molecule in benign and malignant @entity2 @entity0 .

answer: @entity9


abstract: Claudins are integral membrane proteins of the tight junction structures expressed by epithelial and endothelial cells. The present study has evaluated the expression of @entity9 in 10 normal @entity2 hepatoid glands and in 67 hepatoid glands with @entity8 and @entity4 . The lesions studied included normal hepatoid glands (n = 10), @entity7 (n = 10), @entity3 (n = 12), @entity1 (n = 15), @entity1 (n = 15) and @entity1 (n = 15). There was an intensive expression of @entity9 in normal @entity2 hepatoid glands as well as in @entity6 and @entity3 . @entity9 was detected as a well-localised linear circumferential membranous staining pattern of epithelial cells (mature hepatoid cells) in normal hepatoid glands, @entity6 and @entity3 . In @entity7 and @entity3 , the reserve cells showed membrane positivity for the @entity9 molecule. There was a weaker expression in @entity1 . In the @entity1 , the basaloid reserve cells never expressed the @entity9 molecule. The multiple small parts of @entity1 in which the cells exhibited typical hepatoid features showed a well-localised linear circumferential membranous staining pattern for @entity9 . The numerical score for cellular expression of @entity9 was higher in @entity1 than in @entity1 , but moderately lower than in @entity3 . The anaplastic, poorly differentiated @entity1 showed an overexpression of @entity9 . These results suggest that low @entity9 expression in @entity1 is a molecular characteristic indicative of increasing cellular disorientation, @entity5 and invasion by @entity0 cells, and @entity9 seems to be helpful in distinguishing @entity1 from @entity1 and @entity1 of the hepatoid gland. In addition, @entity9 can help distinguish @entity1 from @entity1 of the @entity2 hepatoid gland.

title: Expression of the @entity9 molecule in benign and malignant @entity2 XXXX .

answer: @entity0


abstract: Claudins are integral membrane proteins of the tight junction structures expressed by epithelial and endothelial cells. The present study has evaluated the expression of @entity9 in 10 normal @entity2 hepatoid glands and in 67 hepatoid glands with @entity8 and @entity4 . The lesions studied included normal hepatoid glands (n = 10), @entity7 (n = 10), @entity3 (n = 12), @entity1 (n = 15), @entity1 (n = 15) and @entity1 (n = 15). There was an intensive expression of @entity9 in normal @entity2 hepatoid glands as well as in @entity6 and @entity3 . @entity9 was detected as a well-localised linear circumferential membranous staining pattern of epithelial cells (mature hepatoid cells) in normal hepatoid glands, @entity6 and @entity3 . In @entity7 and @entity3 , the reserve cells showed membrane positivity for the @entity9 molecule. There was a weaker expression in @entity1 . In the @entity1 , the basaloid reserve cells never expressed the @entity9 molecule. The multiple small parts of @entity1 in which the cells exhibited typical hepatoid features showed a well-localised linear circumferential membranous staining pattern for @entity9 . The numerical score for cellular expression of @entity9 was higher in @entity1 than in @entity1 , but moderately lower than in @entity3 . The anaplastic, poorly differentiated @entity1 showed an overexpression of @entity9 . These results suggest that low @entity9 expression in @entity1 is a molecular characteristic indicative of increasing cellular disorientation, @entity5 and invasion by @entity0 cells, and @entity9 seems to be helpful in distinguishing @entity1 from @entity1 and @entity1 of the hepatoid gland. In addition, @entity9 can help distinguish @entity1 from @entity1 of the @entity2 hepatoid gland.

title: Expression of the @entity9 molecule in benign and malignant XXXX @entity0 .

answer: @entity2


abstract: PURPOSE: A planning study to compare @entity3 ( @entity3 ) and intensity-modulated radiotherapy (IMRT) for the treatment of anal canal @entity1 . MATERIALS AND METHODS: Sixteen (8 males and 8 females) @entity0 with @entity1 previously treated radically were identified. @entity3 and IMRT plans were generated and dosimetric comparisons of the plans were performed. The planning goals were to deliver 54Gy to the @entity1 ( @entity2 (54Gy)) and 48Gy to the nodes at risk ( @entity2 (Node)) in 30 fractions. RESULTS: PTVs: @entity3 plans were more homogeneous for both @entity0 and @entity0 . Male @entity0 : @entity3 vs. IMRT: D(max): 55.87+/-0.58 vs. 59.17+/-3.24 (p=0.036); D(min): 52.91+/-0.36 vs. 44.09+/-6.84 (p=0.012); female @entity0 : @entity3 vs. IMRT: D(max): 56.14+/-0.71 vs. 59.47+/-0.81 (p=0.012); D(min): 52.36+/-0.87 vs. 50.97+/-1.42 (p=0.028). OARs: In general, @entity3 plans delivered a lower dose to the peritoneal cavity, external genitalia and the bladder and IMRT plans resulted in greater sparing of the pelvic bones (iliac crest/femur) for both @entity0 and @entity0 . Iliac crest/femur: the difference was significant only for the mean V10Gy of iliac crest in @entity0 (p< or =0.012). External genitalia: @entity3 plans achieved better sparing in @entity0 compared to @entity0 (p< or =0.046). For @entity0 , the mean doses were 18.96+/-3.17 and 15.72+/-3.21 for the @entity3 and IMRT plan, respectively (p< or =0.017). Skin: both techniques achieved comparable sparing of the non-target skin (p=NS). CONCLUSIONS: @entity3 and IMRT techniques achieved comparable target dose coverage and organ sparing, whereas @entity3 plans were more homogeneous for both @entity0 and @entity0 .

title: A treatment planning study comparing XXXX with intensity-modulated radiotherapy for the treatment of @entity1 .

answer: @entity3


abstract: PURPOSE: A planning study to compare @entity3 ( @entity3 ) and intensity-modulated radiotherapy (IMRT) for the treatment of anal canal @entity1 . MATERIALS AND METHODS: Sixteen (8 males and 8 females) @entity0 with @entity1 previously treated radically were identified. @entity3 and IMRT plans were generated and dosimetric comparisons of the plans were performed. The planning goals were to deliver 54Gy to the @entity1 ( @entity2 (54Gy)) and 48Gy to the nodes at risk ( @entity2 (Node)) in 30 fractions. RESULTS: PTVs: @entity3 plans were more homogeneous for both @entity0 and @entity0 . Male @entity0 : @entity3 vs. IMRT: D(max): 55.87+/-0.58 vs. 59.17+/-3.24 (p=0.036); D(min): 52.91+/-0.36 vs. 44.09+/-6.84 (p=0.012); female @entity0 : @entity3 vs. IMRT: D(max): 56.14+/-0.71 vs. 59.47+/-0.81 (p=0.012); D(min): 52.36+/-0.87 vs. 50.97+/-1.42 (p=0.028). OARs: In general, @entity3 plans delivered a lower dose to the peritoneal cavity, external genitalia and the bladder and IMRT plans resulted in greater sparing of the pelvic bones (iliac crest/femur) for both @entity0 and @entity0 . Iliac crest/femur: the difference was significant only for the mean V10Gy of iliac crest in @entity0 (p< or =0.012). External genitalia: @entity3 plans achieved better sparing in @entity0 compared to @entity0 (p< or =0.046). For @entity0 , the mean doses were 18.96+/-3.17 and 15.72+/-3.21 for the @entity3 and IMRT plan, respectively (p< or =0.017). Skin: both techniques achieved comparable sparing of the non-target skin (p=NS). CONCLUSIONS: @entity3 and IMRT techniques achieved comparable target dose coverage and organ sparing, whereas @entity3 plans were more homogeneous for both @entity0 and @entity0 .

title: A treatment planning study comparing @entity3 with intensity-modulated radiotherapy for the treatment of XXXX .

answer: @entity1


abstract: OBJECTIVE: This prospective, randomized, placebo-controlled trial aimed to investigate the efficacy of laser therapy in the treatment of @entity3 ( @entity3 ). BACKGROUND DATA: Low-level laser therapy (LLLT) has been found to have positive effects in the treatment of @entity1 . METHODS: A total of 81 @entity0 were included in this study. Diagnosis of @entity3 was based on both clinical examination and electromyographic (EMG) study. @entity0 were randomly assigned into two groups. Group 1 (n = 41) underwent laser therapy (7 joules/2 min) over the carpal tunnel area. Group 2 (n = 40) received placebo laser therapy. All @entity0 received therapy five times per week, for a total of 10 sessions. @entity0 also used a wrist splint each night. @entity0 were assessed according to @entity2 , hand-pinch grip strength, and functional capacity. @entity2 was evaluated by Visual Analog Scale (VAS; day-night). Hand grip was measured by Jamar dynometer, and pinch grip was measured by pinchmeter. Functional capacity was assessed by a self-administered questionnaire for severity of symptoms. RESULTS: The mean age of the @entity0 (70 @entity0 , 11 @entity0 ) was 49.3 +/- 11.0 (range, 26-78). After therapy there were statistically significant improvements in VAS, pinch grip, and functional capacity measurement in both groups (p < 0.001). Hand grip was found to have been improved in the laser group. In EMG, there were statistically improvements in sensory nerve velocity, and sensory and motor distal latancies in the laser group (p < 0.001). Only sensory nerve velocity was meaningful in the placebo group. CONCLUSION: In using LLLT, (1) there was no difference relative to @entity2 relief and functional capacity during the follow-up in @entity3 @entity0 ; (2) there were positive effects on hand and pinch grip strengths.

title: Laser therapy in the treatment of XXXX : a randomized controlled trial.

answer: @entity3


abstract: BACKGROUND: MicroRNAs (miRs) are small noncoding RNAs that bind to complementary/partially complementary sites in the 3' untranslated regions of target genes to regulate protein production of the target transcript and to induce mRNA degradation or mRNA cleavage. The ability to perform accurate, high-throughput identification of physiologically active @entity3 targets would enable functional characterization of individual miRs. Current target prediction methods include traditional approaches that are based on specific base-pairing rules in the @entity3 's seed region and implementation of cross-species conservation of the target site, and machine learning (ML) methods that explore patterns that contrast true and false @entity3 -mRNA duplexes. However, in the case of the traditional methods research shows that some seed region matches that are conserved are false positives and that some of the experimentally validated target sites are not conserved. RESULTS: We present HuMiTar, a computational method for identifying common targets of miRs, which is based on a scoring function that considers base-pairing for both seed and non-seed positions for @entity0 @entity3 -mRNA duplexes. Our design shows that certain non-seed @entity3 nucleotides, such as 14, 18, 13, 11, and 17, are characterized by a strong bias towards formation of @entity2 . We contrasted HuMiTar with several representative competing methods on two sets of @entity0 @entity3 targets and a set of ten @entity1 oncogenes. Comparison with the two best performing traditional methods, PicTar and TargetScanS, and a representative ML method that considers the non-seed positions, NBmiRTar, shows that HuMiTar predictions include majority of the predictions of the other three methods. At the same time, the proposed method is also capable of finding more true positive targets as a trade-off for an increased number of predictions. Genome-wide predictions show that the proposed method is characterized by 1.99 signal-to-noise ratio and linear, with respect to the length of the mRNA sequence, computational complexity. The ROC analysis shows that HuMiTar obtains results comparable with PicTar, which are characterized by high true positive rates that are coupled with moderate values of false positive rates. CONCLUSION: The proposed HuMiTar method constitutes a step towards providing an efficient model for studying translational gene regulation by miRs.

title: HuMiTar: a sequence-based method for prediction of XXXX microRNA targets.

answer: @entity0


abstract: INTRODUCTION: The aim of this study was to assess the value of the Hardman Index and the Glasgow @entity2 Score in predicting @entity1 in @entity0 with @entity3 ( @entity3 ), and to assess the correlation between the two. @entity0 AND METHODS: @entity0 admitted with @entity3 were identified from a hospital database. Hospital records were reviewed and a retrospective Hardman Index and Glasgow @entity2 Score was calculated. Poor postoperative prognosis was considered at a Glasgow @entity2 Score > 95 or a Hardman Index >or= 3. RESULTS: A total of 96 @entity0 with a median age of 77.5 years (interquartile range, 71-83 years) and a male:female ratio of 2:1 were identified. Of these, 37 @entity0 were not offered surgery and this was associated with 100% mortality. Of the 59 operated @entity0 , 36 (61%) @entity0 died postoperatively. Operated @entity0 had a median Glasgow @entity2 Score of 91 (interquartile range, 77-101) and a Hardman Index of 2 (interquartile range, 1-2). In this group, a Glasgow @entity2 Score > 95 or a Hardman Index >or= 3 was not associated with mortality (P = 0.10 and P = 0.79, respectively). Correlation between the scoring systems was poor (+0.42 tau(b)). CONCLUSIONS: The scoring systems assessed did not help predict the outcome of @entity3 surgery, and correlated poorly with each other. They do not aid clinical judgement.

title: Do scoring systems help in predicting survival following XXXX surgery?

answer: @entity3


abstract: OBJECTIVE: To investigate the protective effects of adenovirus-mediated vascular endothelial growth factor (Ad- @entity10 )165 gene transfer against @entity3 ( @entity3 ) in neonatal @entity1 . METHODS: Ad- @entity10 recombinant adenovirus was constructed by bacterial homologous recombination technology. Seven-day-old @entity1 were randomly assigned to 4 groups: sham-operated (n=20), @entity3 (n=25), buffer-treated (n=20), and Ad- @entity10 -treated (n=25). The @entity3 model was prepared by permanent occlusion of left common carotid artery, followed by exposure to 8% @entity0 for 2 hrs. In the Ad- @entity10 -treated and the Buffer-treated groups, 2 microL recombinant adenovirus suspension or buffer was injected into the left sensorimotor cortex of the @entity1 brain 3 days after @entity3 . Seven days after transplantation, @entity5 mRNA expression was detected using RT-PCR. Neuronal apoptosis was detected by the terminal deoxynucleotidyl transferase-mediated biotinylated @entity11 triphosphate @entity8 end labeling (TUNEL). @entity9 and @entity10 protein were detected using immunohistochemistry. Microvascular density in the cerebral cortex was measured based on @entity9 positive cells. A radial arm maze test was performed from 30 postnatal days to evaluate long-term learning and memory functions. At 35 postnatal days, the @entity1 were sacrificed for cerebral histological examinations by @entity6 and @entity7 . RESULTS: The expression of @entity5 mRNA increased in the Ad- @entity10 -treated group more than in the untreated @entity3 and the buffer-treated groups (p<0.05). The number of apoptotic neurons was less in the Ad- @entity10 -treated group compared with that in the untreated @entity3 and the buffer-treated groups (p<0.05). Microvascular density and @entity10 positive cells increased in the Ad- @entity10 -treated group compared with that in the untreated @entity3 and the buffer-treated groups (p<0.05). In the radial arm maze test, the Ad- @entity10 -treated group had more improved achievements than the @entity3 and the buffer groups (p<0.05). @entity4 and @entity2 were lessened in the Ad- @entity10 -treated group compared with the @entity3 and the buffer groups. CONCLUSIONS: Ad- @entity10 gene transfer can increase the expression of @entity10 mRNA and @entity10 protein, decrease neuronal apoptosis, and increase angiopoiesis in the brain. This attenuates @entity3 and improves long-term learning and memory functions in neonatal @entity1 after @entity3 .

title: [Adenovirus-mediated XXXX gene transfer has neuroprotective effects in neonatal @entity1 following @entity3 ].

answer: @entity5


abstract: OBJECTIVE: To investigate the protective effects of adenovirus-mediated vascular endothelial growth factor (Ad- @entity10 )165 gene transfer against @entity3 ( @entity3 ) in neonatal @entity1 . METHODS: Ad- @entity10 recombinant adenovirus was constructed by bacterial homologous recombination technology. Seven-day-old @entity1 were randomly assigned to 4 groups: sham-operated (n=20), @entity3 (n=25), buffer-treated (n=20), and Ad- @entity10 -treated (n=25). The @entity3 model was prepared by permanent occlusion of left common carotid artery, followed by exposure to 8% @entity0 for 2 hrs. In the Ad- @entity10 -treated and the Buffer-treated groups, 2 microL recombinant adenovirus suspension or buffer was injected into the left sensorimotor cortex of the @entity1 brain 3 days after @entity3 . Seven days after transplantation, @entity5 mRNA expression was detected using RT-PCR. Neuronal apoptosis was detected by the terminal deoxynucleotidyl transferase-mediated biotinylated @entity11 triphosphate @entity8 end labeling (TUNEL). @entity9 and @entity10 protein were detected using immunohistochemistry. Microvascular density in the cerebral cortex was measured based on @entity9 positive cells. A radial arm maze test was performed from 30 postnatal days to evaluate long-term learning and memory functions. At 35 postnatal days, the @entity1 were sacrificed for cerebral histological examinations by @entity6 and @entity7 . RESULTS: The expression of @entity5 mRNA increased in the Ad- @entity10 -treated group more than in the untreated @entity3 and the buffer-treated groups (p<0.05). The number of apoptotic neurons was less in the Ad- @entity10 -treated group compared with that in the untreated @entity3 and the buffer-treated groups (p<0.05). Microvascular density and @entity10 positive cells increased in the Ad- @entity10 -treated group compared with that in the untreated @entity3 and the buffer-treated groups (p<0.05). In the radial arm maze test, the Ad- @entity10 -treated group had more improved achievements than the @entity3 and the buffer groups (p<0.05). @entity4 and @entity2 were lessened in the Ad- @entity10 -treated group compared with the @entity3 and the buffer groups. CONCLUSIONS: Ad- @entity10 gene transfer can increase the expression of @entity10 mRNA and @entity10 protein, decrease neuronal apoptosis, and increase angiopoiesis in the brain. This attenuates @entity3 and improves long-term learning and memory functions in neonatal @entity1 after @entity3 .

title: [Adenovirus-mediated @entity5 gene transfer has neuroprotective effects in neonatal @entity1 following XXXX ].

answer: @entity3


abstract: OBJECTIVE: To investigate the protective effects of adenovirus-mediated vascular endothelial growth factor (Ad- @entity10 )165 gene transfer against @entity3 ( @entity3 ) in neonatal @entity1 . METHODS: Ad- @entity10 recombinant adenovirus was constructed by bacterial homologous recombination technology. Seven-day-old @entity1 were randomly assigned to 4 groups: sham-operated (n=20), @entity3 (n=25), buffer-treated (n=20), and Ad- @entity10 -treated (n=25). The @entity3 model was prepared by permanent occlusion of left common carotid artery, followed by exposure to 8% @entity0 for 2 hrs. In the Ad- @entity10 -treated and the Buffer-treated groups, 2 microL recombinant adenovirus suspension or buffer was injected into the left sensorimotor cortex of the @entity1 brain 3 days after @entity3 . Seven days after transplantation, @entity5 mRNA expression was detected using RT-PCR. Neuronal apoptosis was detected by the terminal deoxynucleotidyl transferase-mediated biotinylated @entity11 triphosphate @entity8 end labeling (TUNEL). @entity9 and @entity10 protein were detected using immunohistochemistry. Microvascular density in the cerebral cortex was measured based on @entity9 positive cells. A radial arm maze test was performed from 30 postnatal days to evaluate long-term learning and memory functions. At 35 postnatal days, the @entity1 were sacrificed for cerebral histological examinations by @entity6 and @entity7 . RESULTS: The expression of @entity5 mRNA increased in the Ad- @entity10 -treated group more than in the untreated @entity3 and the buffer-treated groups (p<0.05). The number of apoptotic neurons was less in the Ad- @entity10 -treated group compared with that in the untreated @entity3 and the buffer-treated groups (p<0.05). Microvascular density and @entity10 positive cells increased in the Ad- @entity10 -treated group compared with that in the untreated @entity3 and the buffer-treated groups (p<0.05). In the radial arm maze test, the Ad- @entity10 -treated group had more improved achievements than the @entity3 and the buffer groups (p<0.05). @entity4 and @entity2 were lessened in the Ad- @entity10 -treated group compared with the @entity3 and the buffer groups. CONCLUSIONS: Ad- @entity10 gene transfer can increase the expression of @entity10 mRNA and @entity10 protein, decrease neuronal apoptosis, and increase angiopoiesis in the brain. This attenuates @entity3 and improves long-term learning and memory functions in neonatal @entity1 after @entity3 .

title: [Adenovirus-mediated @entity5 gene transfer has neuroprotective effects in neonatal XXXX following @entity3 ].

answer: @entity1


abstract: Angioplasty for occluded coronary arteries is less successful than for sub-total stenoses. The Magnarail system (Schneider) has been designed to improve success rates. We used the system in 112 @entity0 with @entity2 (TIMI flow < or = 1) which the operator felt suitable for angioplasty. It was successful (defined as < 50% stenosis) in 75.9% overall, 65.9% in occlusions > 3 months and 83.3% < 3 months. Intimal dissection occurred in 26 instances, more commonly after right coronary angioplasties. One @entity0 died and one procedure was complicated by coronary perforation treated surgically. The procedure was less successful in the right coronary artery (p = 0.02). Coronary calcification (p = 0.03), the absence of a @entity1 (p = 0.04) and the absence of collaterals from another vascular territory (p = 0.04) were all associated with angiographic failure. The mean fluoroscopy time for the procedures was 22.8 +/- 16.9 minutes. The Magnarail system seems highly effective in recanalization of @entity2 .

title: Recanalization of XXXX using the Magnarail system: technique and procedural outcome.

answer: @entity2


abstract: BACKGROUND: Prognosis of @entity0 with acute @entity5 ( @entity5 ) and @entity1 ( @entity1 ) who received primary percutaneous coronary intervention (PCI) has not been fully investigated in the drug-eluting stent (DES) era. This study aimed to evaluate the impact of admission serum @entity7 level on short-term outcomes in @entity0 with acute @entity5 undergoing DES-based primary PCI. METHODS: Primary PCI with DES implantation was attempted in 619 consecutive @entity5 @entity0 within 12 hours of symptom onset. Among them, 86 @entity0 had a serum @entity7 level > or = 115 micromol/L on admission ( @entity1 group), and the remaining 533 @entity0 had normal renal function (non- @entity1 group). The primary endpoint was 30-day major adverse @entity4 (MACE, including death, non-fatal reinfarction, and target vessel revascularization), and the secondary endpoint was subacute stent @entity6 . RESULTS: @entity0 in the @entity1 group were older than those in the non- @entity1 group. There are more female @entity0 in the @entity1 group and they had a history of @entity3 , @entity5 and revascularization. The occurrence rates of Killip class > or = 2 (29.1% vs 18.6%, P = 0.02) and multi-vessel (62.8% vs 44.5%, P = 0.001) and @entity2 (32.6% vs 18.2%, P = 0.002), in-hospital mortality (9.3% vs 3.8%, P = 0.03), and MACE rate during hospitalization (17.4% vs 7.7%, P = 0.006) were higher in the @entity1 group than those in the non- @entity1 group. At a 30-day clinical follow-up, the MACE-free survival rate was significantly reduced in the @entity1 group (76.7% vs 89.9%, P = 0.0003). Angiographic stent @entity6 occurred in 3 (3.5%) and 7 (1.3%) of @entity0 in the @entity1 group and non- @entity1 group, respectively (P = 0.15). Multivariate analysis revealed that the serum @entity7 level > or = 115 micromol/L on admission was an independent predictor for MACE rate at a 30-day follow-up (Hazard ratio (HR) 3.31, 95% CI 1.19 - 9.18, P < 0.001). CONCLUSION: Despite similar prevalence of stent @entity6 at a 30-day clinical follow-up, the short-term prognosis of @entity5 @entity0 with elevated serum @entity7 on admission undergoing DES-based primary PCI remains unfavorable.

title: Impact of admission XXXX level on clinical outcomes of @entity0 with acute @entity5 undergoing primary percutaneous coronary intervention with drug-eluting stent implantation.

answer: @entity7


abstract: BACKGROUND: Prognosis of @entity0 with acute @entity5 ( @entity5 ) and @entity1 ( @entity1 ) who received primary percutaneous coronary intervention (PCI) has not been fully investigated in the drug-eluting stent (DES) era. This study aimed to evaluate the impact of admission serum @entity7 level on short-term outcomes in @entity0 with acute @entity5 undergoing DES-based primary PCI. METHODS: Primary PCI with DES implantation was attempted in 619 consecutive @entity5 @entity0 within 12 hours of symptom onset. Among them, 86 @entity0 had a serum @entity7 level > or = 115 micromol/L on admission ( @entity1 group), and the remaining 533 @entity0 had normal renal function (non- @entity1 group). The primary endpoint was 30-day major adverse @entity4 (MACE, including death, non-fatal reinfarction, and target vessel revascularization), and the secondary endpoint was subacute stent @entity6 . RESULTS: @entity0 in the @entity1 group were older than those in the non- @entity1 group. There are more female @entity0 in the @entity1 group and they had a history of @entity3 , @entity5 and revascularization. The occurrence rates of Killip class > or = 2 (29.1% vs 18.6%, P = 0.02) and multi-vessel (62.8% vs 44.5%, P = 0.001) and @entity2 (32.6% vs 18.2%, P = 0.002), in-hospital mortality (9.3% vs 3.8%, P = 0.03), and MACE rate during hospitalization (17.4% vs 7.7%, P = 0.006) were higher in the @entity1 group than those in the non- @entity1 group. At a 30-day clinical follow-up, the MACE-free survival rate was significantly reduced in the @entity1 group (76.7% vs 89.9%, P = 0.0003). Angiographic stent @entity6 occurred in 3 (3.5%) and 7 (1.3%) of @entity0 in the @entity1 group and non- @entity1 group, respectively (P = 0.15). Multivariate analysis revealed that the serum @entity7 level > or = 115 micromol/L on admission was an independent predictor for MACE rate at a 30-day follow-up (Hazard ratio (HR) 3.31, 95% CI 1.19 - 9.18, P < 0.001). CONCLUSION: Despite similar prevalence of stent @entity6 at a 30-day clinical follow-up, the short-term prognosis of @entity5 @entity0 with elevated serum @entity7 on admission undergoing DES-based primary PCI remains unfavorable.

title: Impact of admission @entity7 level on clinical outcomes of @entity0 with acute XXXX undergoing primary percutaneous coronary intervention with drug-eluting stent implantation.

answer: @entity5


abstract: BACKGROUND: Prognosis of @entity0 with acute @entity5 ( @entity5 ) and @entity1 ( @entity1 ) who received primary percutaneous coronary intervention (PCI) has not been fully investigated in the drug-eluting stent (DES) era. This study aimed to evaluate the impact of admission serum @entity7 level on short-term outcomes in @entity0 with acute @entity5 undergoing DES-based primary PCI. METHODS: Primary PCI with DES implantation was attempted in 619 consecutive @entity5 @entity0 within 12 hours of symptom onset. Among them, 86 @entity0 had a serum @entity7 level > or = 115 micromol/L on admission ( @entity1 group), and the remaining 533 @entity0 had normal renal function (non- @entity1 group). The primary endpoint was 30-day major adverse @entity4 (MACE, including death, non-fatal reinfarction, and target vessel revascularization), and the secondary endpoint was subacute stent @entity6 . RESULTS: @entity0 in the @entity1 group were older than those in the non- @entity1 group. There are more female @entity0 in the @entity1 group and they had a history of @entity3 , @entity5 and revascularization. The occurrence rates of Killip class > or = 2 (29.1% vs 18.6%, P = 0.02) and multi-vessel (62.8% vs 44.5%, P = 0.001) and @entity2 (32.6% vs 18.2%, P = 0.002), in-hospital mortality (9.3% vs 3.8%, P = 0.03), and MACE rate during hospitalization (17.4% vs 7.7%, P = 0.006) were higher in the @entity1 group than those in the non- @entity1 group. At a 30-day clinical follow-up, the MACE-free survival rate was significantly reduced in the @entity1 group (76.7% vs 89.9%, P = 0.0003). Angiographic stent @entity6 occurred in 3 (3.5%) and 7 (1.3%) of @entity0 in the @entity1 group and non- @entity1 group, respectively (P = 0.15). Multivariate analysis revealed that the serum @entity7 level > or = 115 micromol/L on admission was an independent predictor for MACE rate at a 30-day follow-up (Hazard ratio (HR) 3.31, 95% CI 1.19 - 9.18, P < 0.001). CONCLUSION: Despite similar prevalence of stent @entity6 at a 30-day clinical follow-up, the short-term prognosis of @entity5 @entity0 with elevated serum @entity7 on admission undergoing DES-based primary PCI remains unfavorable.

title: Impact of admission @entity7 level on clinical outcomes of XXXX with acute @entity5 undergoing primary percutaneous coronary intervention with drug-eluting stent implantation.

answer: @entity0


abstract: BACKGROUND AND AIM: Descriptive and experimental evaluations of @entity1 support services require an outcome questionnaire that is valid, responsive to change, feasible and interpretable. This paper describes the development of such a tool. DEVELOPMENT OF THE QUESTIONNAIRE: A validated individualised measure MYMOP was adapted and piloted in two centres, and a multidisciplinary research team used this experience to develop the new questionnaire, Measure Yourself Concerns and Wellbeing (MYCaW). MYCaW requires @entity0 to nominate one or two concerns and, using a seven-point scale, to score these concerns and their general feeling of wellbeing. The follow-up questionnaire also includes the open question 'Reflecting on your time with this Centre, what were the most important aspects for you?' INVESTIGATING VALIDITY: During 2003 the two centres administered MYCaW to all new @entity0 , before and after a course of treatment. @entity0 nominated concerns that spanned physical, emotional and psychosocial concerns. For @entity0 completing follow-up questionnaires (n=254 at the Cavendish Centre and n=267 at the Bristol Cancer Help Centre), the mean change (S.D.) for the first concern score was 2.9 (1.63) and 1.91 (1.58) for the second concern score 2.5 (1.73)/1.77 (1.96) and for the wellbeing score 1.4 (1.8)/0.61 (1.52), respectively. The open question collected valuable extra data. DISCUSSION: MYCaW is a questionnaire that is appropriate for the service offered, acceptable to @entity0 , practitioners and researchers, and is responsive to change. Further validation work is planned.

title: Measure Yourself Concerns and Wellbeing (MYCaW): an individualised questionnaire for evaluating outcome in XXXX support care that includes complementary therapies.

answer: @entity1


abstract: PURPOSE: To investigate the utility of positron emission tomography (PET) in @entity0 treated with stereotactic body radiotherapy (SBRT) for stage I @entity1 ( @entity1 ) on prospective institutional trials. @entity0 AND METHODS: Fifty-eight @entity0 with medically inoperable stage I @entity1 who participated in prospective phase I and II trials of SBRT, had >or=2 years of follow-up, and received FDG-PET imaging are the focus of this evaluation. Fifty-seven of 58 @entity0 received pre-SBRT FDG-PET to confirm stage I status. All @entity0 received stereotactic body frame immobilization and treatment with 7-10 photon beams. SBRT total doses ranged from 24 to 72Gy in three fractions. No elective nodal irradiation was undertaken. Regular follow-up with planned CT imaging was performed on all @entity0 . Post-SBRT FDG-PET was not mandated by protocol and was typically ordered upon concern for disease recurrence. Thirty-eight post-SBRT PET studies were performed in 28 @entity0 at a median 17.3 months following SBRT. RESULTS: With a median follow-up of 42.5 months, the 3-year actuarial overall survival and local control for this select subset of our SBRT experience were 48.9% and 74.8%, respectively. Pre-SBRT FDG-PET SUV did not predict 3-year overall survival or local control. Fourteen of 57 @entity0 eventually failed in nodal stations by CT and/or PET. Isolated first site of failure was nodal in 6 @entity0 (10%). Out of 28 @entity0 with post-SBRT PET, 4 (14%) had delayed PET imaging (22-26 months after SBRT) showing moderate @entity2 activity (SUV 2.5-5.07), but no evidence of local, nodal, or distant recurrence by clinical examination and conventional imaging performed 20-26 months following these concerning PET findings. CONCLUSIONS: Isolated nodal recurrence following PET-staged I @entity1 treated with SBRT is uncommon. Moderate post-SBRT PET @entity2 activity may persist 2 years following treatment without definite evidence of recurrence. Further study is needed to confirm these results in larger populations with longer follow-up.

title: FDG-PET and stereotactic body radiotherapy (SBRT) for stage I XXXX .

answer: @entity1


abstract: The primary immune response to Helix pamatia haemocyanin (HPH) was investigated in sixty-one @entity0 with various clinical signs of @entity5 and compared to that of controls. Anti-HPH antibody response was only found abnormal in @entity0 with @entity2 and visceral metastases, apparent from decreased 7S and increased 19S antibody levels. In vitro HPH-induced lymphocyte transformation, in contrast, was not only decreased in this late stage, but also in part of the @entity0 in the beginning of the disease and was then correlated with subsequent @entity1 recurrence within 6 months. Generally, @entity0 with positive lymphocyte transformation showed significantly higher 7S anti-HPH titres (mean 3-3 +/- 2-4 than @entity0 without (1-7 +/- 1-6). In contrast to the lymphocyte transformation reaction, anti-HPH antibody response was not correlated with subsequent @entity1 recurrence. The same phenomenon of decreased 7S and increased 19S antibody response as in the @entity5 @entity0 with @entity6 was observed to a less extent in controls with ageing. Anamnestic antibody responses to diphtheria and @entity4 toxoid and serum IgG and IgA levels were found normal. Elevated serum IgM levels were more frequently observed in @entity0 with localized (19/31) and disseminated disease (11/29) than in controls (2/31). These results suggest that @entity5 @entity0 develop @entity3 in final stages with visceral metastases. A previous study showed that minor defects in lymphocyte function in an early stage as measured by HPH-induced lymphocyte transformation have predictive value for subsequent @entity1 recurrence.

title: Primary immune response to Helix pomatia haemocyanin in XXXX . Relationship between 19S and 7S antibody response and in vitro lymphocyte transformation.

answer: @entity5


abstract: Down syndrome (DS), or Trisomy 21, is the most common genetic cause of @entity2 and @entity3 in the @entity0 population. Bioinformatic annotation has established that @entity0 chromosome 21 (Hsa21) harbors five microRNA (miRNAs) genes: @entity10 , @entity8 , @entity12 , @entity7 , and @entity11 . Our laboratory recently demonstrated that Hsa21-derived miRNAs are overexpressed in DS brain and heart specimens. The aim of this study was to identify important Hsa21-derived miRNA/mRNA target pairs that may play a role, in part, in mediating the DS phenotype. We demonstrate by luciferase/target mRNA 3'-untranslated region reporter assays, and gain- and loss-of-function experiments that @entity7 and -802 can regulate the expression of the predicted mRNA target, the @entity4 -CpG-binding protein ( @entity6 ). We also demonstrate that @entity6 is underexpressed in DS brain specimens isolated from either @entity0 or @entity1 . We further demonstrate that, as a consequence of attenuated @entity6 expression, transcriptionally activated and silenced @entity6 target genes, @entity9 / @entity9 and @entity5 / @entity5 , are also aberrantly expressed in these DS brain specimens. Finally, in vivo silencing of endogenous @entity7 or -802, by antagomir intra-ventricular injection, resulted in the normalization of @entity6 and @entity6 target gene expression. Taken together, these results suggest that improper repression of @entity6 , secondary to trisomic overexpression of Hsa21-derived miRNAs, may contribute, in part, to the abnormalities in the neurochemistry observed in the brains of DS individuals. Finally these results suggest that selective inactivation of Hsa21-derived miRNAs may provide a novel therapeutic tool in the treatment of DS.

title: Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in XXXX Down syndrome brains.

answer: @entity0


abstract: BACKGROUND: Prolonged @entity5 following early preterm prelabour rupture of membranes (PPROM) is traditionally associated with high neonatal mortality and significant risk of @entity1 . However, recent evidence points to an apparent improvement in outcome. AIMS: To document current neonatal outcomes following rupture of membranes prior to 25 weeks with severe persistent @entity5 and a latency to delivery of at least 14 days. METHODS: A retrospective case note analysis over a 28-month period at Saint Luc University Hospital, Brussels. RESULTS: From 23 pregnancies that were complicated by PPROM prior to 25 weeks, 15 @entity0 were born after 24 weeks with a latency of more than 14 days and persistent @entity5 . Nine @entity0 (60%) had severe @entity3 and clinical signs compatible with @entity1 . Seven of these @entity0 (78%) responded to high frequency ventilation and inhaled @entity2 therapy with good clinical outcome but two died from severe @entity3 . Five @entity0 showed no clinical signs of @entity1 and responded to conventional neonatal management. One of these @entity0 died at 77 days of age of @entity4 . One @entity0 was not resuscitated and died within minutes of birth, following prior discussion with the perinatal team and the parents. Survivors in this high-risk group (73%) had low morbidity at the time of discharge. SUMMARY: The favourable neonatal survival and morbidity figures are in keeping with recent published evidence. This study confirms improved outcome even amongst the highest risk @entity0 with documented persistent @entity5 .

title: Contemporary neonatal outcome following rupture of membranes prior to 25 weeks with prolonged XXXX .

answer: @entity5


abstract: BACKGROUND: @entity2 's rising incidence is largely attributable to the increased detection of small renal masses. Although surgery rates have paralleled this incidence trend, mortality continues to rise, calling into question the necessity of surgery for all @entity0 with renal masses. Using a population-based cohort, a competing risk analysis was performed to estimate @entity0 survival after surgery for @entity2 , as a function of @entity0 age and @entity1 size at diagnosis. METHODS: With data from the Surveillance, Epidemiology, and End Results Program (1983-2002), a cohort was assembled of 26,618 @entity0 with surgically treated, @entity2 . @entity0 were sorted into 20 age- @entity1 size categories and the numbers of @entity0 that were alive, dead from @entity2 , and dead from other causes were tabulated. Poisson regression models were fitted to obtain estimates of @entity1 -specific and competing-cause mortality. RESULTS: Age-specific @entity2 mortality was stable across all size strata but varied inversely with @entity1 size. @entity0 with the @entity1 enjoyed the lowest @entity1 -specific mortality (5% for masses<or=4 cm). Competing-cause mortality rose with increasing @entity0 age. The estimated 5-year competing-cause mortality for elderly subjects (>or=70 years) was 28.2% (95% confidence interval [CI]: 25.9%-30.8%), irrespective of @entity1 size. CONCLUSIONS: Despite surgical therapy, competing-cause mortality for @entity0 with renal masses rises with increasing @entity0 age. After 5 years, one-third of elderly @entity0 (>or=70 years) will die from other causes, suggesting the need for prospective studies to evaluate the role of active surveillance as an initial therapeutic approach for some small renal masses.

title: Five-year survival after surgical treatment for XXXX : a population-based competing risk analysis.

answer: @entity2


abstract: BACKGROUND: @entity12 ( @entity12 ), usually an @entity1 , is caused by mutations in the @entity11 ( @entity7 )-neurophysin II preprohormone leading to aberrant preprohormone processing and gradual destruction of @entity7 -secreting cells. @entity0 typically present between 1 and 6 years of age with @entity8 and @entity10 . OBJECTIVE: Clinical, biochemical, and genetic studies of three new cases of @entity12 presenting in early infancy. @entity0 : Three Palestinian cousins presented with failure to thrive, @entity5 , @entity2 , and @entity3 . The parents were asymptomatic. @entity0 developed @entity9 (154-163 mmol/l) and serum hyperosmolality (>320 mOsm/kg), while urine osmolality remained between 73 and 229 mOsm/kg. Plasma @entity7 levels were low, and the posterior pituitary bright spot was absent on magnetic resonance imaging (MRI). All @entity0 responded to desmopressin. RESULTS: @entity0 were homozygous and parents were heterozygous for microsatellite markers flanking the @entity7 gene. All @entity0 were homozygous for the @entity13 ( @entity6 to @entity4 ) substitution affecting mature @entity7 . A founder effect with the single original kindred carrying the @entity13 mutation was confirmed by microsatellite analysis, but @entity0 in that family presented only at 2 years of age. In microsatellite analysis, the new kindred @entity0 were not homozygous and did not share a single allele at the aquaporin 2 and vasopressin receptor-2 genes locuses. CONCLUSION: This is the first description of @entity12 presenting in the neonatal period. The unusual early clinical and radiological (MRI) presentation argues against gradual destruction of @entity7 -secreting neurons as the pathophysiological mechanism. Factors beside allelism of @entity7 -related genes must influence the age of @entity12 presentation given the founder effect demonstrated for the @entity13 mutation.

title: XXXX : onset in early infancy.

answer: @entity12


abstract: Serotype-specific patterns of reovirus disease in the CNS of newborn @entity0 segregate with the viral S1 gene segment, which encodes attachment protein sigma1 and nonstructural protein sigma1s. The importance of receptor recognition in target cell selection by reovirus implicates the sigma1 protein as the primary effector of disease outcome. However, the contribution of sigma1s to reovirus disease is unknown. To define the function of sigma1s in reovirus pathogenesis, we generated a sigma1s-deficient virus by altering a single @entity1 to disrupt the sigma1s translational start site. Viruses were recovered that contain nine gene segments from strain type 3 Dearing and either the wild-type or sigma1s-null S1 gene segment from strain type 1 Lang. Following peroral inoculation of newborn @entity0 , both viruses replicated in the intestine, although the wild-type virus achieved higher yields than the sigma1s-null virus. However, unlike the wild-type virus, the sigma1s-deficient virus failed to disseminate to sites of secondary viral replication, including the brain, heart, and liver. Within the small intestine, both viruses were detected in Peyer's patches, but only the wild-type virus reached the mesenteric lymph node. Concordantly, wild-type virus, but not sigma1s-deficient virus, was detected in the blood of infected animals. Wild-type and sigma1s-null viruses produced equivalent titers following intracranial inoculation, indicating that sigma1s is dispensable for viral growth in the @entity0 CNS. These results suggest a key role for sigma1s in virus spread from intestinal lymphatics to the bloodstream, thereby allowing the establishment of @entity2 and dissemination to sites of secondary replication within the infected host.

title: Reovirus nonstructural protein sigma1s is required for establishment of XXXX .

answer: @entity2


abstract: OBJECTIVE: This study evaluated the incidence and types of adverse drug reactions (ADRs) associated with medications used to treat active toxoplasmic @entity13 . METHODS: This was a retrospective review of the clinical records of a consecutive series of @entity0 with active toxoplasmic @entity13 , examined between March 1991 and August 1998. For inclusion in the review, @entity0 had to have been diagnosed with active toxoplasmic @entity13 , been treated with a single drug or drug combination indicated for this condition, and been followed for at least 8 weeks. @entity0 who were lost to follow-up or who had incomplete chart data were excluded. Demographic data, pertinent aspects of the medical history, drug treatments, and ADRs associated with antitoxoplasmic treatment were recorded. RESULTS: Fifty-five @entity0 met the criteria for inclusion in the review. In descending order of frequency, they received antitoxoplasmic treatment with @entity10 (n = 50), @entity12 (n = 40), @entity11 (n = 33), @entity1 - @entity2 (n = 16), and @entity15 (n = 10), alone or in combination. Twenty-two @entity0 (40.0%) had a total of 27 ADRs. The most frequently occurring ADRs were @entity9 (19 [34.5%]), mostly associated with @entity12 (9/40 [22.5%]) and @entity10 (6/50 [12.0%]), and @entity4 such as @entity3 (6 [10.9%]), stomach upset (6 [10.9%]), and @entity6 (1 [1.8%]), mostly associated with @entity10 (5/50 [10.0%], 3/50 [6.0%], and 1/50 [2.0%], respectively). The incidence of ADRs associated with individual antitoxoplasmic drugs was 30.0% (3/10) for @entity15 , 26.0% (13/50) for @entity10 , 22.5% (9/40) for @entity12 , 12.5% (2/16) for @entity7 , and 12.1% (4/33) for @entity11 . There were 2 serious ADRs: @entity5 in a @entity0 treated with @entity10 and @entity8 in a @entity0 treated with @entity11 . Twenty-five ADRs were reversed on drug discontinuation; the remaining 2 were mild and did not require drug discontinuation. CONCLUSIONS: The overall incidence of treatment-associated ADRs was high (40.0%) in these @entity0 with @entity14 . The most frequently occurring ADRs were @entity9 and @entity4 .

title: Adverse drug reactions to treatments for XXXX : a retrospective chart review.

answer: @entity14


abstract: OBJECTIVE: The @entity8 is 'an anatomical entity in which the pituitary fossa is partially or completely filled with cerebrospinal fluid, while the pituitary gland is compressed against the posterior rim of the fossa'. Reports of this entities relating to the @entity5 not situated in the pituitary fossa, have rarely been reported. METHODS: In order to analyze the incidence and relationship of @entity8 in @entity0 having @entity5 , the authors reviewed preoperative magnetic resonance imaging (MRI) of 72 @entity0 with @entity5 regardless of pathology except the @entity4 . The @entity0 were operated in single institute by one surgeon. There were 25 males and 47 females and mean @entity0 age was 53 years old (range from 5 years to 84 years). @entity1 volume was ranged from 2 cc to 238 cc. RESULTS: The overall incidence of @entity8 was positive in 57/72 cases (79.2%). Sorted by the pathology, @entity8 was highest in @entity6 (88.9%, p = 0.042). The @entity8 was correlated with @entity0 's increasing age (p = 0.003) and increasing @entity1 volume (p = 0.016). CONCLUSION: Careful review of brain MRI with periodic follow up is necessary for the detection of secondary @entity8 in @entity0 with @entity5 . In @entity0 with confirmed @entity8 , follow up is mandatory for the management of @entity7 , cerebrospinal fluid (CSF) @entity2 and @entity3 .

title: Analysis of XXXX secondary to the @entity5 .

answer: @entity8


abstract: OBJECTIVE: The @entity8 is 'an anatomical entity in which the pituitary fossa is partially or completely filled with cerebrospinal fluid, while the pituitary gland is compressed against the posterior rim of the fossa'. Reports of this entities relating to the @entity5 not situated in the pituitary fossa, have rarely been reported. METHODS: In order to analyze the incidence and relationship of @entity8 in @entity0 having @entity5 , the authors reviewed preoperative magnetic resonance imaging (MRI) of 72 @entity0 with @entity5 regardless of pathology except the @entity4 . The @entity0 were operated in single institute by one surgeon. There were 25 males and 47 females and mean @entity0 age was 53 years old (range from 5 years to 84 years). @entity1 volume was ranged from 2 cc to 238 cc. RESULTS: The overall incidence of @entity8 was positive in 57/72 cases (79.2%). Sorted by the pathology, @entity8 was highest in @entity6 (88.9%, p = 0.042). The @entity8 was correlated with @entity0 's increasing age (p = 0.003) and increasing @entity1 volume (p = 0.016). CONCLUSION: Careful review of brain MRI with periodic follow up is necessary for the detection of secondary @entity8 in @entity0 with @entity5 . In @entity0 with confirmed @entity8 , follow up is mandatory for the management of @entity7 , cerebrospinal fluid (CSF) @entity2 and @entity3 .

title: Analysis of @entity8 secondary to the XXXX .

answer: @entity5


abstract: OBJECTIVE: @entity5 ( @entity5 ) is a risk factor for primary acute graft failure following lung transplantation. @entity5 hereby contributes to morbidity and mortality after lung transplantation. We have previously shown that surfactant pretreatment ameliorates @entity5 up to 1 week after reperfusion. However, the impact of surfactant pretreatment on long-term outcome following @entity5 is unknown. Therefore, the objective of this study was to investigate the effect of surfactant pretreatment on long-term outcome following @entity5 . METHODS: Male @entity0 (n=63) were randomized to receive intratracheally administered porcine surfactant (400mg/kg) or no pretreatment. One hour thereafter, animals underwent 120min of warm @entity1 by clamping the bronchus, pulmonary artery and vein of the left lung. A third group was sham-operated; a fourth group served as unoperated controls. Animals were killed on day 30 or 90 after surgery. Arterial oxygenation and lung compliance were determined. Broncho-alveolar lavage fluid (BALf) was collected to assess surfactant function and alveolar protein. Leukocyte infiltration was determined by flowcytometry in BALf, lung tissue and thoracic lymph nodes. Lungs of three animals per group were used for histological assessment. RESULTS: Lung compliance was lower on day 30 and day 90 after @entity5 than in sham-operated controls (day 30 V(max) 6.1+/-2.1 vs 12.6+/-1.3, day 90 6.9+/-3.0 vs 12.1+/-1.6; C(max) day 30 0.49+/-0.17 vs 1.08+/-0.21, day 90 0.67+/-0.31 vs 1.11+/-0.17). Furthermore, the number of @entity4 RA(+)-lymphocytes in left lung tissue was decreased on day 90 compared to unoperated animals (230.633+/-96.770 vs 696.347+/-202.909) and the number of macrophages elevated in left BALf on day 90. HE slides of @entity5 animals were scored as fibroproliferative with moderate @entity3 . Surfactant pretreatment improved lung compliance (V(max) day 30 11.7+/-1.8, day 90 11.1+/-1.2; C(max) day 30 1.04+/-0.23, day 90 1.16+/-0.21) and normalized the number of @entity4 RA(+)-lymphocytes (769.555+/-421.016) in left lung tissue. Furthermore lung architecture on HE slides was on return to normal. However, more @entity7 (+) @entity6 (+)-lymphocytes on day 30 (754.788+/-97.269 vs 430.409+/-109.909) and more macrophages on day 90 (2.144.000+/-630.633 vs 867.454+/-383.220) were measured in pretreated lung tissue compared to @entity5 animals. CONCLUSIONS: Severe @entity5 caused extensive @entity2 up to 90 days postoperatively. Surfactant pretreatment normalized pulmonary function, but resulted in an increased number of @entity7 (+) @entity6 (+)-cells and macrophages in lung tissue.

title: Surfactant pretreatment decreases long-term damage after XXXX -reperfusion injury of the lung.

answer: @entity1


abstract: Proteomic approaches are used to identify biomarkers, to monitor pathological changes inside of cells and for a better diseases diagnosis. Comparable changes in protein homeostasis also occur in differentiating cells and proteomic techniques should be suitable to identify biomarkers that indicate different steps of cellular development. The C3 exoenzyme from @entity3 (C3bot) inactivates Rho GTPases and induces morphological cellular changes like cell rounding and neurite outgrowth [G. Ahnert-Hilger, M. H  ltje, G. Grosse, G. Pickert, C. Mucke, B. Nixdorf-Bergweiler, P. Boquet, F. Hofmann, I. Just, J. Neurochem. 90 (2004) 9]. To investigate these observations further a comparative proteomic approach has been chosen to elucidate C3bot effects in the @entity2 cell line model SH-SY5Y. The screening method applied for biomarker detection was based on the stable isotope approach isobaric tagging for relative and absolute quantification (iTRAQ). Proteins of C3bot-treated and untreated cells were digested and peptides were labeled by the iTRAQ reagent, combined, and separated by means of a two-dimensional nano-HPLC system. Peptide analysis was performed in a MALDI- @entity1 / @entity1 mass spectrometer. Identification and quantification of peptides and their corresponding proteins were accomplished by @entity0 / @entity0 spectra analysis. Overall, five replicate measurements identified 355 different proteins of which 235 were accessible for quantification. C3bot altered the concentration of 55 proteins (at least 1.3-fold) and several proteins were identified as possible biomarker candidates that indicate C3bot-induced cellular changes.

title: Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from @entity3 using the iTRAQ protocol and LC- XXXX / @entity0 analysis.

answer: @entity0


abstract: Proteomic approaches are used to identify biomarkers, to monitor pathological changes inside of cells and for a better diseases diagnosis. Comparable changes in protein homeostasis also occur in differentiating cells and proteomic techniques should be suitable to identify biomarkers that indicate different steps of cellular development. The C3 exoenzyme from @entity3 (C3bot) inactivates Rho GTPases and induces morphological cellular changes like cell rounding and neurite outgrowth [G. Ahnert-Hilger, M. H  ltje, G. Grosse, G. Pickert, C. Mucke, B. Nixdorf-Bergweiler, P. Boquet, F. Hofmann, I. Just, J. Neurochem. 90 (2004) 9]. To investigate these observations further a comparative proteomic approach has been chosen to elucidate C3bot effects in the @entity2 cell line model SH-SY5Y. The screening method applied for biomarker detection was based on the stable isotope approach isobaric tagging for relative and absolute quantification (iTRAQ). Proteins of C3bot-treated and untreated cells were digested and peptides were labeled by the iTRAQ reagent, combined, and separated by means of a two-dimensional nano-HPLC system. Peptide analysis was performed in a MALDI- @entity1 / @entity1 mass spectrometer. Identification and quantification of peptides and their corresponding proteins were accomplished by @entity0 / @entity0 spectra analysis. Overall, five replicate measurements identified 355 different proteins of which 235 were accessible for quantification. C3bot altered the concentration of 55 proteins (at least 1.3-fold) and several proteins were identified as possible biomarker candidates that indicate C3bot-induced cellular changes.

title: Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from @entity3 using the iTRAQ protocol and LC- @entity0 / XXXX analysis.

answer: @entity0


abstract: Proteomic approaches are used to identify biomarkers, to monitor pathological changes inside of cells and for a better diseases diagnosis. Comparable changes in protein homeostasis also occur in differentiating cells and proteomic techniques should be suitable to identify biomarkers that indicate different steps of cellular development. The C3 exoenzyme from @entity3 (C3bot) inactivates Rho GTPases and induces morphological cellular changes like cell rounding and neurite outgrowth [G. Ahnert-Hilger, M. H  ltje, G. Grosse, G. Pickert, C. Mucke, B. Nixdorf-Bergweiler, P. Boquet, F. Hofmann, I. Just, J. Neurochem. 90 (2004) 9]. To investigate these observations further a comparative proteomic approach has been chosen to elucidate C3bot effects in the @entity2 cell line model SH-SY5Y. The screening method applied for biomarker detection was based on the stable isotope approach isobaric tagging for relative and absolute quantification (iTRAQ). Proteins of C3bot-treated and untreated cells were digested and peptides were labeled by the iTRAQ reagent, combined, and separated by means of a two-dimensional nano-HPLC system. Peptide analysis was performed in a MALDI- @entity1 / @entity1 mass spectrometer. Identification and quantification of peptides and their corresponding proteins were accomplished by @entity0 / @entity0 spectra analysis. Overall, five replicate measurements identified 355 different proteins of which 235 were accessible for quantification. C3bot altered the concentration of 55 proteins (at least 1.3-fold) and several proteins were identified as possible biomarker candidates that indicate C3bot-induced cellular changes.

title: Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from XXXX using the iTRAQ protocol and LC- @entity0 / @entity0 analysis.

answer: @entity3


abstract: 1. @entity2 ( @entity2 ) and egg yolk proteins of mature female @entity3 ( @entity3 ) were studied comparatively with reference to their immunological and some physicochemical properties. 2. @entity2 was considered to be composed of two egg proteins, @entity4 , which were isolated from the egg yolk by gel filtration. 3. The molecular weights of @entity2 , @entity4 were estimated by gel filtration to be approx 600,000, 300,000 and 35,000, respectively. 4. The analysis with @entity1 electrophoresis indicated that E1 consisted of two subunits with molecular weights of 90,000 and 15,000, and E2 was estimated to be a dimer of a molecule of 15,000. 5. Male and immature female trout were injected with @entity0 -17 beta, and the production of proteins with the same antigenicity with @entity2 was demonstrated.

title: Comparative studies on immunochemical properties of female-specific serum protein and egg yolk proteins in XXXX ( @entity3 ).

answer: @entity3


abstract: 1. @entity2 ( @entity2 ) and egg yolk proteins of mature female @entity3 ( @entity3 ) were studied comparatively with reference to their immunological and some physicochemical properties. 2. @entity2 was considered to be composed of two egg proteins, @entity4 , which were isolated from the egg yolk by gel filtration. 3. The molecular weights of @entity2 , @entity4 were estimated by gel filtration to be approx 600,000, 300,000 and 35,000, respectively. 4. The analysis with @entity1 electrophoresis indicated that E1 consisted of two subunits with molecular weights of 90,000 and 15,000, and E2 was estimated to be a dimer of a molecule of 15,000. 5. Male and immature female trout were injected with @entity0 -17 beta, and the production of proteins with the same antigenicity with @entity2 was demonstrated.

title: Comparative studies on immunochemical properties of female-specific serum protein and egg yolk proteins in @entity3 ( XXXX ).

answer: @entity3


abstract: OBJECT: The goal of this report was to describe the safety and effectiveness of nucleus ventralis intermedius (VIM) thalamotomy performed with the Leksell Gamma Knife (GK) for the treatment of essential @entity1 (ET). METHODS: One hundred seventy-two @entity0 underwent a total of 214 VIM thalamotomy procedures with the Leksell GK between February 1994 and March 2007 for treatment of disabling ET. Eleven @entity0 were lost to follow-up less than 1 year after the procedures, so that in this report the authors describe the results in 161 @entity0 who underwent a total of 203 thalamotomies (119 unilateral and 42 bilateral). RESULTS: There were statistically significant decreases (p < 0.0001) in @entity1 scores for both writing and drawing. The mean postoperative follow-up duration for all @entity0 was 44 +/- 33 months. Fifty-four @entity0 have been followed for more than 60 months posttreatment. There were 14 @entity0 who suffered neurological side effects that were temporary (6) or permanent (8), which accounted for 6.9% of the 203 treatments. All complications were related to lesions that grew larger than expected. CONCLUSIONS: A VIM thalamotomy with the Leksell GK offers a safe and effective alternative for surgical treatment of ET. It is particularly applicable to @entity0 who are not ideal candidates for deep brain stimulation but can be offered to all @entity0 who are considering surgical intervention for ET.

title: Gamma Knife thalamotomy for treatment of essential XXXX : long-term results.

answer: @entity1


abstract: OBJECTIVE: In animal experiments many hormones were demonstrated in immune cells. However, very few data are at our disposal in the case of @entity0 immune cells. In an earlier experiment, @entity7 , endorphin and T(3) were studied and found in different subsets of @entity0 immune cells. Here, three biogenic @entity6 ( @entity2 , @entity3 and @entity5 ) were studied. METHODS: Biogenic @entity8 content of immunophenotyped @entity0 lymphocytes from 15 blood donors were investigated by multicolor flow cytometry using anti-biogenic @entity8 antibodies. Monocytes and granulocytes separated by size and granularity were also studied. RESULTS: Each biogenic @entity8 could be detected in each subset of leukocytes, except @entity5 and @entity3 in granulocytes. Activated T cells contained a higher amount of the @entity6 , and @entity4 +B cells a higher amount of @entity2 , related to the whole lymphocyte population and to other subsets. Monocytes contained more @entity2 and @entity5 than lymphocytes and granulocytes contained twice as much @entity2 as monocytes and three times as much as lymphocytes. CONCLUSION: @entity0 lymphocytes contain the three biogenic @entity8 , similar to @entity1 . However, while each @entity8 was present in monocytes, in granulocytes @entity3 and @entity5 were not demonstrated. The results call attention to the possible extrapolation of animal data to @entity0 lymphocytes and monocytes, but in the case of granulocytes, caution is needed. Taking into consideration earlier results, activated T cells appear to have an important role in the loss or production of hormones inside the immune system.

title: Presence and distribution of biogenic @entity6 ( XXXX , @entity3 and @entity5 ) in immunophenotyped @entity0 immune cells.

answer: @entity2