abstract: We have examined responses of @entity0 lacking mu, delta and kappa opioid receptor ( @entity6 , @entity5 and @entity7 , respectively) genes, as well as combinatorial mutants, in @entity1 models. This is the first truly comparative study of all three opioid receptor-deficient @entity0 , with genotypes and gender analysis using @entity0 on the hybrid 50% 129/SV : 50% C57BL/6 genetic background. In the tail-immersion test, only @entity7 -/- females showed decreased withdrawal latencies. This modification was also found in @entity6 / @entity7 and @entity6 / @entity5 / @entity7 , but not @entity6 / @entity5 mutants. The hotplate test revealed @entity4 for @entity6 -/-, a phenotype which was also observed in double mutants involving the @entity6 deletion, and in the triple mutants. The tail-pressure test showed increased response for both @entity6 -/- and @entity5 -/- mutants, a modification which was enhanced in the triple-mutant @entity0 . In the @entity2 test, @entity6 -/- and @entity5 -/- @entity0 showed increased responses in the early and late phases, respectively, while the triple mutant tended to show enhanced nociception in both phases. Finally, the enhanced response of @entity7 -/- @entity0 in the writhing test, which we have demonstrated previously, was confirmed in double @entity6 / @entity7 - and triple-mutant @entity0 . Together, the data support the existence of an antinociceptive opioid tone. Each receptor presents a distinct pattern of activities, with mu receptors influencing responses to mechanical, chemical and thermal nociception at a supraspinal level, kappa receptors involved in spinally mediated thermal nociception and chemical @entity3 , and delta receptors modulating mechanical nociception and @entity1 . Phenotypes of mutant @entity0 were subtle, suggesting a low endogenous opioid tone in the regulation of physiological @entity1 .

title: Acute antinociceptive responses in single and combinatorial opioid receptor knockout XXXX : distinct mu, delta and kappa tones.

answer: @entity0


abstract: OBJECTIVE: To compare the short-term and medium-term result of stent implantation with pharmaceutical thrombolysis in @entity0 with @entity5 . METHODS: From January, 2004 to December, 2008, thirty-five @entity0 diagnosed acute superior @entity8 , 12 @entity0 treated with stent implantation (interventional therapy group) and 23 @entity0 with pharmaceutical thrombolysis (thrombolytic therapy group). Interventional therapy group treated with @entity4 and stent implantation assisted with anticoagulation, antiplatelet and @entity4 agents. Thrombolytic therapy group used urokinase combined with anticoagulation, antiplatelet and @entity4 agents. All @entity0 had taken @entity7 and @entity3 orally after discharged and followed up. The clinical effects of both groups were evaluated separately and the Fisher exact test was used to analysis the significant differences. RESULTS: In the 23 cases of thrombolytic therapy group, 7 cases was effective, 16 cases was ineffective (7 cases aggravated or died, 9 cases turn to surgical operation). In the 12 cases of interventional therapy group, 10 cases treated with stent implantation (1 case died of acute @entity6 3 days after interventional operation), 2 cases failed in recanalizing. All @entity0 were followed up after discharged (range 1 - 48 months, mean 15    12 months), 1 case in thrombolytic therapy group was stable, 6 cases died of the recurrence of @entity5 ; 7 cases in interventional therapy group was stable, 1 case died of acute @entity6 20 months after interventional operation ( @entity2 not appeared), 1 case had @entity2 reoccurred and recovered by superior mesenteric artery thrombolysis. CONCLUSIONS: In the treatment of acute superior @entity8 , stent implantation was obviously superior to pharmaceutical thrombolysis in improving @entity2 and survival, therefore it could provided a reliable choice for the @entity0 who had not appeared @entity1 .

title: [Acute superior XXXX : a contrast study on short-and mid-term result between stent implantation and pharmaceutical thrombolysis].

answer: @entity8


abstract: @entity1 (also called @entity1 ), absorbed in the intestine and stored mainly in the liver and fat, is normally maintained at significant concentrations in the @entity0 blood plasma. @entity1 is constitutively metabolized at high levels in certain tissues such as the small intestine and eyes. @entity3 (RA) produced at high levels in the intestine plays important roles in @entity2 and immune tolerance. RA at basal levels is required for immune cell survival and activation. During immune responses, enzymes metabolizing @entity1 are induced in certain types of immune cells such as dendritic cells (DCs) and tissue cells for induced production of RA. As a result, induced gradients of RA are formed during immune responses in the body. RA regulates gene expression, differentiation, and function of diverse immune cells. The cells under the influence of RA in terms of differentiation include myeloid cells such as neutrophils, macrophages, and DCs. Also included are lymphoid cells such as effector T cells, regulatory T cells, and B cells. Our current understanding of the function of RA in regulation of these immune cells is reviewed in this chapter.

title: XXXX , immunity, and inflammation.

answer: @entity3


abstract: In the developed world, @entity1 are more frequent in males than females. Recent observations from Greece suggest that the number of females is increasing. AIM: The present study investigates gender and age statistics among subjects with @entity1 or @entity5 . METHODS: Five hundred and twelve subjects of Greek origin participated in this analysis. Chi-square and logistic regression statistics were used to compare if there are differences in @entity0 ' gender and age, stratified by histological type. RESULTS: @entity1 and @entity5 exhibited equal distributions among @entity0 and @entity0 . @entity0 were diagnosed at a much younger age than @entity0 . Our data also indicates a progression in the process of epithelial @entity1 development, as benign @entity5 was diagnosed 2-4 years earlier than @entity4 and 8 years earlier than @entity2 ( @entity2 ). The same age difference was observed in @entity3 , although the male to female ratio was 3:1. In regards to anatomy, 47% of @entity2 appeared in the tongue. The most prevalent site for the development of @entity3 was the gingival (50%), followed by the palate (40%). CONCLUSION: Although @entity1 occurs earlier in @entity0 than @entity0 , the risk of females tends to be similar to that of males.

title: @entity5 and XXXX : female cases increase in Greece.

answer: @entity1


abstract: In the developed world, @entity1 are more frequent in males than females. Recent observations from Greece suggest that the number of females is increasing. AIM: The present study investigates gender and age statistics among subjects with @entity1 or @entity5 . METHODS: Five hundred and twelve subjects of Greek origin participated in this analysis. Chi-square and logistic regression statistics were used to compare if there are differences in @entity0 ' gender and age, stratified by histological type. RESULTS: @entity1 and @entity5 exhibited equal distributions among @entity0 and @entity0 . @entity0 were diagnosed at a much younger age than @entity0 . Our data also indicates a progression in the process of epithelial @entity1 development, as benign @entity5 was diagnosed 2-4 years earlier than @entity4 and 8 years earlier than @entity2 ( @entity2 ). The same age difference was observed in @entity3 , although the male to female ratio was 3:1. In regards to anatomy, 47% of @entity2 appeared in the tongue. The most prevalent site for the development of @entity3 was the gingival (50%), followed by the palate (40%). CONCLUSION: Although @entity1 occurs earlier in @entity0 than @entity0 , the risk of females tends to be similar to that of males.

title: XXXX and @entity1 : female cases increase in Greece.

answer: @entity5


abstract: We have studied the role of immunologically mediated @entity1 in the orbital tissue damage of @entity3 . @entity1 ( @entity1 ) against eye muscle (EM) cells and @entity2 ( @entity2 ) was demonstrated in a small proportion of @entity0 , all of whom had severe, recent disease. Antibody-mediated (complement-dependent) @entity1 against @entity2 was found in only a few @entity0 . No @entity0 showed lysis above background with EM targets. @entity1 activity against @entity2 was absorbed by preincubation of serum with thyroid cells, eye muscle cells, and @entity2 , as well as thyroid, eye muscle and orbital connective tissue membranes. Both EM and @entity2 were able to express class II MHC HLA-DR antigens when stimulated by gamma interferon, phytohemagglutinin or activated T lymphocytes. DR-positive target cells were much more susceptible to lysis, in both @entity1 and lymphocyte-mediated @entity1 , than DR negative cells. When DR-positive @entity2 and EM were used as targets in @entity1 assays, the degree of lysis determined as 51Cr release given by serum from @entity0 with @entity3 was enhanced, but only in those @entity0 showing positive tests with DR-negative targets. Intrathyroidal T lymphocytes obtained from a @entity0 with @entity3 were more cytotoxic against DR-positive @entity2 and EM than equal numbers of her peripheral blood T lymphocytes. @entity1 and lymphocyte-mediated @entity1 against @entity2 and eye muscle cells are thus associated with target cell HLA-DR antigen expression and are likely to be mechanisms for in vivo tissue damage in @entity3 . The identity of the mononuclear cell subpopulation effecting cell-mediated @entity1 against orbital target cells, and the possible significance of reaction of cytotoxic antibodies against orbital, thyroid-shared antigens are unclear.

title: Mechanisms of immune damage in XXXX .

answer: @entity3


abstract: PURPOSE: Routine imaging for staging @entity1 is not recommended according to current guidelines. We characterized patterns of care and factors associated with imaging overuse. MATERIALS AND METHODS: We used SEER-Medicare linked data to identify @entity0 diagnosed with @entity1 from 2004 to 2005, and determined if imaging (computerized tomography, magnetic resonance imaging, bone scan, abdominal ultrasound) was obtained following @entity1 diagnosis before treatment. RESULTS: Of the 6,444 @entity0 identified with low risk disease 2,330 (36.2%) underwent imaging studies. Of these @entity0 1,512 (23.5%), 1,710 (26.5%) and 118 (1.8%) underwent cross-sectional imaging (computerized tomography or magnetic resonance imaging), bone scan and abdominal ultrasound, respectively. Radiation therapy vs surgery was associated with greater odds of imaging ( @entity2 , 95% CI 1.68-2.35, p <0.01), while active surveillance vs surgery was associated with lower odds of imaging (OR 0.44, 95% CI 0.34-0.56, p <0.01). Associated with increased odds of imaging was median household income greater than  60,000 (OR 1.41, 95% CI 1.11-1.79, p <0.01), and @entity0 from New Jersey vs San Francisco ( @entity3 , 95% CI 2.24-4.33, p <0.01) experienced greater odds of imaging. @entity0 living in areas with greater than 90% vs less than 75% high school education experienced lower odds of imaging (OR 0.76, 95% CI 0.6-0.95, p = 0.02). CONCLUSIONS: There is widespread overuse and significant geographic variation in the use of imaging to stage @entity1 . Moreover treatment associated variation in imaging was noted with the greatest vs lowest imaging use observed for radiation therapy vs active surveillance.

title: Overuse of imaging for staging XXXX .

answer: @entity1


abstract: A 30-year-old @entity0 , with a history of @entity3 , which was treated by radiotherapy nine years previously, presented with occasional @entity4 and @entity2 . A nasopharyngeal biopsy showed no recurrence. The imaging revealed a sphenoidal sinus mucocele. Endoscopic marsupialization of the mucocele allowed clinical improvement. A 56-year-old @entity0 presented, five years after radiotherapy for @entity3 , with a fronto-orbital mass. CT-scan revealed a fronto-ethmoidal mucocele. Nasopharyngeal biopsy showed @entity1 recurrence. Marsupialization of mucocele was performed. Recurrence of the @entity3 was treated by radiotherapy and chemotherapy. Sphenoidal sinus mucocele developing after radiotherapy for @entity3 has rarely been reported. CT scan and MRI are useful tools in making the diagnosis. Biopsy is required to diagnose recurrence or associated radio-induced @entity1 . Endoscopic approach gives good results.

title: [Post-radiation mucocele in two @entity0 treated for XXXX ].

answer: @entity1


abstract: A 30-year-old @entity0 , with a history of @entity3 , which was treated by radiotherapy nine years previously, presented with occasional @entity4 and @entity2 . A nasopharyngeal biopsy showed no recurrence. The imaging revealed a sphenoidal sinus mucocele. Endoscopic marsupialization of the mucocele allowed clinical improvement. A 56-year-old @entity0 presented, five years after radiotherapy for @entity3 , with a fronto-orbital mass. CT-scan revealed a fronto-ethmoidal mucocele. Nasopharyngeal biopsy showed @entity1 recurrence. Marsupialization of mucocele was performed. Recurrence of the @entity3 was treated by radiotherapy and chemotherapy. Sphenoidal sinus mucocele developing after radiotherapy for @entity3 has rarely been reported. CT scan and MRI are useful tools in making the diagnosis. Biopsy is required to diagnose recurrence or associated radio-induced @entity1 . Endoscopic approach gives good results.

title: [Post-radiation mucocele in two XXXX treated for @entity1 ].

answer: @entity0


abstract: It has been estimated that during 1955-1959 in southeastern @entity2 , approximately 4000 @entity0 developed @entity8 due to ingestion of @entity11 ( @entity11 ), a fungicide added to @entity7 seedlings. @entity0 subsequently developed bullae on sun-exposed areas, @entity5 , @entity6 , @entity3 and porphyrinuria. @entity0 born to mothers who had ingested the grain were exposed to @entity11 in maternal milk and transplacentally, resulting in the death of @entity0 under the age of two. In this follow-up study, 204 @entity0 with a past history of @entity11 -induced @entity8 were re-evaluated. There were 132 males and 72 females, with an average age of 32.1 years, an average age of onset of 7.1 years and a duration of 2.4 years. The clinical features of the 204 @entity0 were: scarring of the face and hands in 86.7%, @entity5 in 71.1%, @entity6 in 47.1%, pinched facies in 41.2%, fragile skin in 37.7%, painless @entity4 in 66.6%, small hands in 64.2%, an enlarged liver in 4.4% and an enlarged thyroid in 37.3%; most @entity0 also showed @entity1 . Urine and stool @entity9 levels were determined in all @entity0 . Seventeen showed elevated levels of one of the @entity10 and eight were considered still porphyric after 25-30 years. A total of 56 specimens of @entity0 milk obtained from porphyric mothers were analysed for @entity11 . The average value was 0.51 ppm compared with 0.07 in controls. After @entity11 ingestion, abnormal @entity9 metabolism, dermatological, orthopaedic and neurological findings, and @entity11 residues in the milk of porphyric @entity0 have been shown to persist at least for 25-30 years.

title: @entity8 : XXXX -induced @entity8 .

answer: @entity11


abstract: It has been estimated that during 1955-1959 in southeastern @entity2 , approximately 4000 @entity0 developed @entity8 due to ingestion of @entity11 ( @entity11 ), a fungicide added to @entity7 seedlings. @entity0 subsequently developed bullae on sun-exposed areas, @entity5 , @entity6 , @entity3 and porphyrinuria. @entity0 born to mothers who had ingested the grain were exposed to @entity11 in maternal milk and transplacentally, resulting in the death of @entity0 under the age of two. In this follow-up study, 204 @entity0 with a past history of @entity11 -induced @entity8 were re-evaluated. There were 132 males and 72 females, with an average age of 32.1 years, an average age of onset of 7.1 years and a duration of 2.4 years. The clinical features of the 204 @entity0 were: scarring of the face and hands in 86.7%, @entity5 in 71.1%, @entity6 in 47.1%, pinched facies in 41.2%, fragile skin in 37.7%, painless @entity4 in 66.6%, small hands in 64.2%, an enlarged liver in 4.4% and an enlarged thyroid in 37.3%; most @entity0 also showed @entity1 . Urine and stool @entity9 levels were determined in all @entity0 . Seventeen showed elevated levels of one of the @entity10 and eight were considered still porphyric after 25-30 years. A total of 56 specimens of @entity0 milk obtained from porphyric mothers were analysed for @entity11 . The average value was 0.51 ppm compared with 0.07 in controls. After @entity11 ingestion, abnormal @entity9 metabolism, dermatological, orthopaedic and neurological findings, and @entity11 residues in the milk of porphyric @entity0 have been shown to persist at least for 25-30 years.

title: XXXX : @entity11 -induced @entity8 .

answer: @entity8


abstract: It has been estimated that during 1955-1959 in southeastern @entity2 , approximately 4000 @entity0 developed @entity8 due to ingestion of @entity11 ( @entity11 ), a fungicide added to @entity7 seedlings. @entity0 subsequently developed bullae on sun-exposed areas, @entity5 , @entity6 , @entity3 and porphyrinuria. @entity0 born to mothers who had ingested the grain were exposed to @entity11 in maternal milk and transplacentally, resulting in the death of @entity0 under the age of two. In this follow-up study, 204 @entity0 with a past history of @entity11 -induced @entity8 were re-evaluated. There were 132 males and 72 females, with an average age of 32.1 years, an average age of onset of 7.1 years and a duration of 2.4 years. The clinical features of the 204 @entity0 were: scarring of the face and hands in 86.7%, @entity5 in 71.1%, @entity6 in 47.1%, pinched facies in 41.2%, fragile skin in 37.7%, painless @entity4 in 66.6%, small hands in 64.2%, an enlarged liver in 4.4% and an enlarged thyroid in 37.3%; most @entity0 also showed @entity1 . Urine and stool @entity9 levels were determined in all @entity0 . Seventeen showed elevated levels of one of the @entity10 and eight were considered still porphyric after 25-30 years. A total of 56 specimens of @entity0 milk obtained from porphyric mothers were analysed for @entity11 . The average value was 0.51 ppm compared with 0.07 in controls. After @entity11 ingestion, abnormal @entity9 metabolism, dermatological, orthopaedic and neurological findings, and @entity11 residues in the milk of porphyric @entity0 have been shown to persist at least for 25-30 years.

title: @entity8 : @entity11 -induced XXXX .

answer: @entity8


abstract: Psychotropic drug surveys serve to provide retrospective control of actual treatment conditions in @entity1 hospitals. Data of overall drug consumptions and those indicating the time pattern of medication were recorded at 7 census days for 1,415 inpatients of the @entity1 hospital of the Free University of Berlin. Drug-treated @entity0 with 3.15 different psychotropic drugs on average during their stay. Neuroleptics were the most chosen compound group with regard to all @entity0 treated (62.2%), the number of prescriptions (48.3%) and the sum of psychotropic days (57.9%). Sedatives (i.e. @entity3 and @entity4 ) were given to more patients than antidepressants (41.0% vs. 29.3%), but accounted for only 5.7% of all psychotropic drug days (21.4% in case of antidepressants). The analysis of time pattern revealed that the prescription of neuroleptics was favoured on all census days, while prescribing for antiparkinsonian and @entity2 drugs increased also over time, but not for sedatives. Mean daily doses of most neuroleptics peaked near the 10th day after the @entity0 ' admission, while those of antidepressants increased steadily until the @entity0 were discharged. Monotherapy was found in 59.0%, drug combinations in 41.0% of prescriptions (on all census days). The proportion of drug combinations in relation to monotherapy increased the longer the @entity0 were in hospital. Among all drug combinations, two drugs had been combined in 79.2%, three or more in 20.8%. Two or more neuroleptics given simultaneously were involved in 44.9% of all combinations--an unexpected finding calling for more systematic investigation.

title: Longitudinal assessment of psychotropic drug use in acutely-ill XXXX inpatients.

answer: @entity1


abstract: BACKGROUND: In the clinical diagnosis of @entity3 in @entity5 ( @entity5 ), it may be difficult to distinguish between @entity1 and the various degrees of pre-existing @entity4 ( @entity4 ). Serial measurements of both cognitive function and behaviour are required. The aim of the present study was to evaluate the performance of non-demented adults with @entity5 on a subject-directed instrument, the Prudhoe Cognitive Function Test (PCFT), preliminary to its serial use in a prospective study. METHODS: From 1985 to 1986, 85 non-demented hospitalized adults with @entity5 were interviewed using the PCFT. The @entity2 ( @entity2 ) was administered to the carers. The subjects' levels of @entity4 (graded from mild through moderate, severe and profound to untestable) were based on their scores on the Stanford-Binet Intelligence Scale, as reported in the medical records, and the relationship between level of disability and performance on the PCFT and @entity2 , and their respective domains, was examined. RESULTS: Both scales produced a wide range of scores and the correlation between them was highly significant. Both scales correlated highly significantly with the degree of @entity4 , but more subjects with high levels (i.e. profound to untestable) of disability obtained very low or zero scores on the PCFT and its domains than on the @entity2 . CONCLUSIONS: The PCFT provides a reliable quantitative measure of cognitive function in subjects with @entity5 , and could be a useful adjunct to the diagnosis of @entity3 in prospective studies. However, the almost uniformly low scores obtained by those with high levels of @entity4 suggests that its power to detect @entity1 will be limited to those who are less disabled, while the @entity2 may be more useful than the PCFT in detecting deterioration in @entity0 with profound @entity4 .

title: Preliminary evaluation of a scale to assess cognitive function in adults with XXXX : the Prudhoe Cognitive Function Test.

answer: @entity5


abstract: OBJECTIVE: To describe the success rate of and the quality of life after global endometrial ablation in an @entity1 population. METHODS: A follow-up survey was mailed to 72 @entity0 who had undergone global endometrial ablation. The survey included a @entity4 -specific NovaSure endometrial ablation questionnaire. The mean follow-up time was 2.5years. RESULTS: Forty-four @entity0 (61%) responded, with a mean body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) of 30.5. Overall, @entity0 reported a decrease in missed social activities, in inability to perform activities of daily living, in missed work days, in @entity3 tendencies, and in @entity2 . The @entity5 rate was 37%, and the success rate (those not requiring any further therapeutic treatment) was 86%. @entity0 satisfaction was 93%. CONCLUSION: Global endometrial ablation improved quality of life for @entity1 @entity0 with @entity4 and had a high rate of satisfaction, even for @entity0 not achieving @entity5 . @entity0 with a BMI of more than 34 showed a trend toward failure and a higher rate of hysterectomy.

title: Success rate, quality of life, and descriptive analysis after generalized endometrial ablation in an XXXX population.

answer: @entity1


abstract: Microvascular endothelial cells play a key role in transplant immunology. They are also important targets for calcineurin inhibitors. We recently demonstrated elevated numbers of circulating endothelial cells in renal transplant recipients with and without rejection in comparison with healthy controls. Because these @entity0 received either @entity1 or @entity3 , we speculated that endothelial damage from calcineurin inhibitors might be responsible for these findings. In the present study, we tested the hypothesis that treatment with @entity5 inhibitors leads to an increase in circulating endothelial cells. We studied 57 renal transplant recipients: 19 on a @entity4 -free immunosuppressive regimen and 38 @entity0 on a standard immunosuppressive regimen, including @entity1 , and matched them for age and serum @entity2 . Endothelial cells were isolated from peripheral blood with anti-CD-146-coated immunomagnetic Dynabeads and were counted by fluorescence microscopy. @entity0 with @entity1 therapy had elevated numbers of circulating endothelial cells (median 26, range 12 to 82 cells/mL) compared with healthy controls (median 6, range 0 to 82 cells/mL; P<0.001). @entity0 without @entity4 treatment had significantly lower cell numbers (median 12, range 0 to 32 cells/mL; P<0.003) and were not significantly different from normal, untreated controls. In conclusion, renal transplant recipients who do not receive calcineurin inhibitors have significantly lower numbers of circulating endothelial cells than their age- and @entity2 -matched counterparts who receive these drugs. We suggest that elevated numbers of circulating endothelial cells indicate damage from calcineurin inhibitors in renal transplant recipients and that circulating endothelial cells are a novel marker of endothelial damage.

title: Circulating endothelial cells are a novel marker of XXXX -induced endothelial damage.

answer: @entity1


abstract: PURPOSE: Pregnancy increases stress on the circulation of parturient with @entity9 secondary to @entity10 and increases the risk of peripartum @entity3 , especially during delivery. This study investigated the epidural anesthesia management for cesarean section in pregnant @entity0 with @entity10 and @entity9 . METHODS: 48 parturients with @entity10 and @entity9 that had cesarean section deliveries with epidural anesthesia in the Union Hospital, Fujian Medical University (Fuzhou, China) from Jan 2002 to Dec 2012 were retrospectively analyzed. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), central venous pressure (CVP), fluid intake volume and fluid output volume ( @entity1  +  urine volume) were analyzed. RESULTS: Medication included digitalis drugs for @entity3 or potential @entity3 , @entity11 and @entity5 for chronic @entity3 and beta blockers for @entity4 . Frequent @entity6 were treated with @entity8 and @entity7 . @entity2 was administered when @entity3 occurred during less than 37  weeks gestation. HR, SAP, DAP, MAP and CVP were significantly increased at the time of delivery. The fluid intake volume was more elevated in the NYHA III-IV group of parturients than the NYHA I-II group, while fluid output volume was less. All parturients survived. CONCLUSIONS: Epidural anesthesia was applied successfully for cesarean sections for parturients with @entity10 and @entity9 .

title: Epidural anesthesia for cesarean section for pregnant @entity0 with @entity10 and XXXX .

answer: @entity9


abstract: PURPOSE: Pregnancy increases stress on the circulation of parturient with @entity9 secondary to @entity10 and increases the risk of peripartum @entity3 , especially during delivery. This study investigated the epidural anesthesia management for cesarean section in pregnant @entity0 with @entity10 and @entity9 . METHODS: 48 parturients with @entity10 and @entity9 that had cesarean section deliveries with epidural anesthesia in the Union Hospital, Fujian Medical University (Fuzhou, China) from Jan 2002 to Dec 2012 were retrospectively analyzed. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), central venous pressure (CVP), fluid intake volume and fluid output volume ( @entity1  +  urine volume) were analyzed. RESULTS: Medication included digitalis drugs for @entity3 or potential @entity3 , @entity11 and @entity5 for chronic @entity3 and beta blockers for @entity4 . Frequent @entity6 were treated with @entity8 and @entity7 . @entity2 was administered when @entity3 occurred during less than 37  weeks gestation. HR, SAP, DAP, MAP and CVP were significantly increased at the time of delivery. The fluid intake volume was more elevated in the NYHA III-IV group of parturients than the NYHA I-II group, while fluid output volume was less. All parturients survived. CONCLUSIONS: Epidural anesthesia was applied successfully for cesarean sections for parturients with @entity10 and @entity9 .

title: Epidural anesthesia for cesarean section for pregnant @entity0 with XXXX and @entity9 .

answer: @entity10


abstract: PURPOSE: Pregnancy increases stress on the circulation of parturient with @entity9 secondary to @entity10 and increases the risk of peripartum @entity3 , especially during delivery. This study investigated the epidural anesthesia management for cesarean section in pregnant @entity0 with @entity10 and @entity9 . METHODS: 48 parturients with @entity10 and @entity9 that had cesarean section deliveries with epidural anesthesia in the Union Hospital, Fujian Medical University (Fuzhou, China) from Jan 2002 to Dec 2012 were retrospectively analyzed. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), central venous pressure (CVP), fluid intake volume and fluid output volume ( @entity1  +  urine volume) were analyzed. RESULTS: Medication included digitalis drugs for @entity3 or potential @entity3 , @entity11 and @entity5 for chronic @entity3 and beta blockers for @entity4 . Frequent @entity6 were treated with @entity8 and @entity7 . @entity2 was administered when @entity3 occurred during less than 37  weeks gestation. HR, SAP, DAP, MAP and CVP were significantly increased at the time of delivery. The fluid intake volume was more elevated in the NYHA III-IV group of parturients than the NYHA I-II group, while fluid output volume was less. All parturients survived. CONCLUSIONS: Epidural anesthesia was applied successfully for cesarean sections for parturients with @entity10 and @entity9 .

title: Epidural anesthesia for cesarean section for pregnant XXXX with @entity10 and @entity9 .

answer: @entity0


abstract: BACKGROUND AND PURPOSE: The natural history of unruptured @entity2 remains unclear, and management strategy is not well defined. METHODS: From January 2003 to December 2012, we enrolled @entity0 with @entity3 in our institution. In total, 2252 @entity0 with 2897 @entity3 were eligible for analysis, and 1960 eligible @entity3 were conservatively managed. Precise 3-dimensional evaluation was conducted using computed tomography angiography, digital subtraction angiography, or magnetic resonance angiography. We then assessed the risk of @entity6 , mortality, and morbidity associated with @entity3 characteristics, demographics, and known health/lifestyle risk factors. RESULTS: The mean follow-up duration was 7388 @entity3 -years. During observation, 56 @entity6 , resulting in an overall @entity1 rate per year of 0.76% (95% confidence interval, 0.58-0.98). The mean initial visit to @entity1 interval was 547 days. @entity3 size, location, daughter sac, and history of @entity4 were significant independent predictors for @entity6 . @entity3 that were >= 5 mm were associated with a significantly increased risk of @entity1 when compared with 2-to 4-mm @entity3 (unadjusted hazard ratio, 12.24; 95% confidence interval, 7.15-20.93). Of 56 @entity0 who experienced @entity5 , 29 (52 %) died or were rendered severely disabled. Of the @entity0 who had large or @entity3 , none recovered without deficits, and the mortality rate after @entity1 was 69%. For @entity3 sized <5 mm, the mortality rate was 18%. CONCLUSIONS: Larger @entity3 are at greater risk for @entity1 and poor outcome. Ethnic factors may play a role in the risk of @entity1 .

title: Risk Analysis of XXXX : Prospective 10-Year Cohort Study.

answer: @entity2


abstract: This study compares the clinical outcomes of 60 consecutive @entity0 who received an allogeneic blood or marrow stem cell transplant (BMT) from one Human @entity5 (HLA) mismatched related donors with those of 120 matched @entity0 who had HLA identical sibling donors. The control @entity0 were matched for diagnosis, disease status, conditioning regimen, and age at BMT. All @entity0 received standard CYA and @entity4 for GVHD prophylaxis. The probability of @entity3 ( @entity3 ) at 5 years was 35% in the study group compared to 56% in the control group. The relapse rates and acute GVHD rates did not differ between the two groups. Graft failure was a significant problem in the study group compared to the control group (13 vs. 0%, p < 0.0001). All cases of graft failure occurred in @entity0 with a mismatch in the host-versus-graft direction. BMT-related @entity1 were also increased in the study group. Forty percent of @entity1 were caused by infection in the study group vs. 19% in the control group (p < 0.01). In conclusion, the @entity3 of @entity0 receiving marrow/stem cells from one antigen mismatched related donors was inferior to that of controls with HLA-identical related donors. There was an increase in mortality related to @entity2 occurring in the setting of an increased frequency of graft failure in these @entity0 .

title: Influence of one human XXXX mismatch on outcome of allogeneic bone marrow transplantation from related donors.

answer: @entity5


abstract: BACKGROUND: Data on @entity5 ( @entity5 ) events after different types of shoulder surgery have not previously been available in large numbers in the United Kingdom. We aimed to determine baseline postoperative complication rates with reference to national @entity2 prophylaxis guidelines. METHODS: Diagnostic and operative codes are routinely collected on every @entity0 admitted to the hospital in the English NHS. Data for a 42-month period were analyzed for planned shoulder surgery (total replacement, hemiarthroplasty, or arthroscopy) and proximal humeral @entity1 surgery (internal fixation or replacement). In addition, complications during the two 6-month periods before and after the implementation of national thromboprophylaxis guidelines were compared. Rates of symptomatic @entity3 , @entity4 , and mortality within 90 days were extracted. RESULTS: For total shoulder replacement (4,061 @entity0 ), @entity3 , @entity4 , and mortality rates were 0%, 0.20%, and 0.22%, respectively. For arthroscopic procedures (65,302 @entity0 ), the rates were less than 0.01%, 0.01%, and 0.03%, respectively. For proximal humeral @entity1 surgery (internal fixation or replacement, 4,696 @entity0 ), the rates were 0.19%, 0.40%, and 3.02%, respectively. There was no significant difference in the @entity5 event or mortality rates before and after the introduction of the 2007 National Institute for Health and Clinical Excellence guidelines after arthroscopy or proximal humeral @entity1 surgery. A statistically significant decrease in total shoulder replacement-related mortality was found, from 0.72% (5 @entity0 ) to 0%. DISCUSSION: @entity5 disease is not a significant problem after shoulder surgery, and thromboprophylaxis may not be required, even in high-risk @entity0 . National thromboprophylaxis guidelines did not affect @entity5 event rates.

title: Venous XXXX events are rare after shoulder surgery: analysis of a national database.

answer: @entity2


abstract: The immune responsiveness of @entity0 is altered during pregnancy in order to retain protective properties against disease and at the same time allow tolerance of the fetus. Diseases such as @entity6 ( @entity6 ) have been suggested to arise as a result of maladaptations in these immune alterations. Here we evaluate the effect of @entity6 on the composition of peripheral blood lymphocyte subpopulations using lymphocyte surface antigen expression. Fifty-four @entity0 of various parities with pregnancy-induced @entity1 (PIH) (39 non-proteinuric and 14 proteinuric) and matched controls (30 normotensive pregnant @entity0 (NTP) and 15 healthy non-pregnant @entity0 (NP)) were investigated. Monoclonal antibodies specific for @entity0 T lymphocytes and subpopulations: @entity10 , CD3, @entity3 , @entity4 , @entity5 and activation markers: @entity8 , CD45RA, CD45RO, @entity7 AND HLA(-)DR were used and detected using a two-colour fluorescence analysis with an automated flow cytometer. The total number of T lymphocytes: @entity10 , CD3, @entity3 , @entity4 and @entity5 were significantly decreased in PIH particularly @entity6 (P<0.05). T cells expressing NK surface markers (CD3/ @entity11 (+) @entity9 ) and @entity3 cells expressing HLA(-)DR were higher in @entity6 . @entity4 (+)HLA(-)DR(+) cells and T-helper cells expressing adhesion molecules) @entity3 (+) @entity7 (+)) were higher in NTP than in NP and @entity6 (P<0.05, 0.05). @entity6 is associated with elevated levels of @entity3 (+)HLA(-)DR(+), and CD3(+)NK cells but decreased total numbers of T lymphocytes, and the CD3(+) @entity8 (+) subpopulation. These findings indicate systemic alterations in maternal immunity associated with the @entity6 state. This feature of the disease may contribute to abnormal adaptation to pregnancy resulting in @entity6 and PIH, promoting adverse outcomes including @entity2 .

title: Lymphocyte subpopulations in pregnancy complicated by XXXX .

answer: @entity1


abstract: UNASSIGNED: Fractures with partial collapse of vertebral bodies are generically referred to as " @entity5 " or VCFs. VCFs can have different etiologies comprising @entity2 , bone failure related to @entity3 , or @entity1 affecting bone. VCFs related to @entity3 (benign @entity4 ) and to cancer ( @entity4 ) are commonly found in the elderly population. In the clinical setting, the differentiation between benign and @entity4 is complex and difficult. This paper presents a study aimed at developing a system for computer-aided diagnosis to help in the differentiation between malignant and benign VCFs in magnetic resonance imaging (MRI). We used T1-weighted MRI of the lumbar spine in the sagittal plane. Images from 47 consecutive @entity0 (31 @entity0 , 16 @entity0 , mean age 63 years) were studied, including 19 @entity4 and 54 benign @entity4 . Spectral and fractal features were extracted from manually segmented images of 73 vertebral bodies with VCFs. The classification of malignant vs. benign VCFs was performed using the k-nearest neighbor classifier with the Euclidean distance. Results obtained show that combinations of features derived from Fourier and wavelet transforms, together with the fractal dimension, were able to obtain correct classification rate up to 94.7% with area under the receiver operating characteristic curve up to 0.95.

title: Classification of XXXX in magnetic resonance images using spectral and fractal analysis.

answer: @entity5


abstract: PURPOSE: To assess the prophylactic effect of preoperative application of topical @entity4 on @entity2 control in @entity0 having photorefractive keratectomy (PRK). SETTING: Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. DESIGN: Randomized masked clinical trial. METHODS: In this @entity3 , @entity0 having bilateral PRK received 1 drop of @entity4 0.1% in 1 eye and 1 drop of placebo in the fellow eye 2 hours before PRK. Postoperatively, both arms of the trial (both eyes of each @entity0 ) received topical @entity4 every 6 hours for 2 days. One day and 2 days postoperatively, @entity0 were asked to rate the perceived @entity1 in each eye using an 11-point verbal numerical rating scale. A trained examiner noted the eye-specific responses. RESULTS: All 70 @entity0 (140 eyes) completed the study and were included in the statistical analysis. Twenty-four hours after PRK, @entity0 reported @entity1 scores that were clinically and statistically significantly lower in the eyes pretreated with @entity4 than in the fellow eyes (0.97 versus 2.09) (P=.018). @entity1 scores at 2 days did not differ significantly (P=.877). CONCLUSION: Administration of a single drop of topical @entity4 0.1% 2 hours before PRK seemed to increase the efficacy of @entity2 management in a clinically and statistically significant manner. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Effect of preemptive topical @entity4 on XXXX relief after photorefractive keratectomy.

answer: @entity2


abstract: PURPOSE: To assess the prophylactic effect of preoperative application of topical @entity4 on @entity2 control in @entity0 having photorefractive keratectomy (PRK). SETTING: Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. DESIGN: Randomized masked clinical trial. METHODS: In this @entity3 , @entity0 having bilateral PRK received 1 drop of @entity4 0.1% in 1 eye and 1 drop of placebo in the fellow eye 2 hours before PRK. Postoperatively, both arms of the trial (both eyes of each @entity0 ) received topical @entity4 every 6 hours for 2 days. One day and 2 days postoperatively, @entity0 were asked to rate the perceived @entity1 in each eye using an 11-point verbal numerical rating scale. A trained examiner noted the eye-specific responses. RESULTS: All 70 @entity0 (140 eyes) completed the study and were included in the statistical analysis. Twenty-four hours after PRK, @entity0 reported @entity1 scores that were clinically and statistically significantly lower in the eyes pretreated with @entity4 than in the fellow eyes (0.97 versus 2.09) (P=.018). @entity1 scores at 2 days did not differ significantly (P=.877). CONCLUSION: Administration of a single drop of topical @entity4 0.1% 2 hours before PRK seemed to increase the efficacy of @entity2 management in a clinically and statistically significant manner. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Effect of preemptive topical XXXX on @entity2 relief after photorefractive keratectomy.

answer: @entity4


abstract: BACKGROUND AND AIMS: Obesity is a pro-atherogenic condition and postprandial lipoprotein profile and circulating cytokines changes may contribute to promote the process. The aim of this study is to investigate postprandial metabolic response, lipoprotein oxidation and circulating cytokine levels, after the ingestion of two different meals with different fat/ @entity6 ratio. METHODS AND RESULTS: Ten prepubertal @entity1 @entity0 consumed two meals with the same energy and protein content but with a different @entity6 to fat ratio: 1) @entity5 ( @entity5 ): 61% @entity6 , 27% fat; 2) high fat (HF): 37% @entity6 , 52% fat. The AUC of @entity3 and insulin were significantly (p < 0.05) lower after the HF meal. HF meal was followed by a significant decrease in the @entity2 carried in the HDL fractions, while @entity2 in the small, dense LDL and in the VLDL particles increased, as compared to baseline (p < 0.05 for all). No differences were found in the @entity2 distribution after the @entity5 meal. Moreover, HDL-C concentration was lower (p < 0.05) at 300 min after HF vs. @entity5 meal. Oxidized LDL (ox-LDL) concentration increased after the HF meal but not after the @entity5 meal [9.3(2.2) vs 1.8(2.2)% from baseline, P < 0.02)]. A positive association (r > 0.3, P < 0.05) was observed between the densest LDL particles and the ox-LDL plasma levels. A reduction of @entity4 was found at 120 min after the @entity5 [-23.3(5.5) vs -8.4(3.8)% from baseline, P < 0.05)] compared with the HF meal. CONCLUSION: A simple change of    25% of energy load from fat to @entity6 in a meal significantly improves postprandial pro-atherogenic factors in @entity1 @entity0 .

title: Pro-atherogenic postprandial profile: meal-induced changes of lipoprotein sub-fractions and inflammation markers in XXXX @entity0 .

answer: @entity1


abstract: BACKGROUND AND AIMS: Obesity is a pro-atherogenic condition and postprandial lipoprotein profile and circulating cytokines changes may contribute to promote the process. The aim of this study is to investigate postprandial metabolic response, lipoprotein oxidation and circulating cytokine levels, after the ingestion of two different meals with different fat/ @entity6 ratio. METHODS AND RESULTS: Ten prepubertal @entity1 @entity0 consumed two meals with the same energy and protein content but with a different @entity6 to fat ratio: 1) @entity5 ( @entity5 ): 61% @entity6 , 27% fat; 2) high fat (HF): 37% @entity6 , 52% fat. The AUC of @entity3 and insulin were significantly (p < 0.05) lower after the HF meal. HF meal was followed by a significant decrease in the @entity2 carried in the HDL fractions, while @entity2 in the small, dense LDL and in the VLDL particles increased, as compared to baseline (p < 0.05 for all). No differences were found in the @entity2 distribution after the @entity5 meal. Moreover, HDL-C concentration was lower (p < 0.05) at 300 min after HF vs. @entity5 meal. Oxidized LDL (ox-LDL) concentration increased after the HF meal but not after the @entity5 meal [9.3(2.2) vs 1.8(2.2)% from baseline, P < 0.02)]. A positive association (r > 0.3, P < 0.05) was observed between the densest LDL particles and the ox-LDL plasma levels. A reduction of @entity4 was found at 120 min after the @entity5 [-23.3(5.5) vs -8.4(3.8)% from baseline, P < 0.05)] compared with the HF meal. CONCLUSION: A simple change of    25% of energy load from fat to @entity6 in a meal significantly improves postprandial pro-atherogenic factors in @entity1 @entity0 .

title: Pro-atherogenic postprandial profile: meal-induced changes of lipoprotein sub-fractions and inflammation markers in @entity1 XXXX .

answer: @entity0


abstract: @entity6 is an @entity10 characterized by systemic and vascular accumulation of @entity8 (Gb(3)) caused by a deficiency of the lysosomal enzyme alpha-galactosidase A ( @entity9 ). The condition is associated with an increased morbidity and mortality due to @entity3 , @entity4 , and early onset of @entity2 . Hemizygous males are primarily affected clinically with variable expression in heterozygous females. Gene-therapy trials have been initiated recently in @entity9 knockout @entity1 models of @entity6 by using a variety of viral vectors. In the present investigation we administered single i.v. injections of 1 x 10(10) genomes of recombinant adeno-associated virus (rAAV) encoding the @entity0 @entity9 gene driven by a modified @entity5 @entity11 promoter to @entity9 knockout (Fabry) @entity1 . @entity1 were analyzed for expression of @entity9 activity and Gb(3) levels in liver, kidney, heart, spleen, small intestine, lung, and brain. Administration of the rAAV- @entity11 -hAGA vector resulted in stable expression of @entity9 in organs of the Fabry @entity1 for >6 months. @entity9 activity in the organs became equal to or higher than that of wild-type @entity1 . Accumulated Gb(3) in the liver, heart, and spleen was reduced to that of wild-type @entity1 with lesser but significant reductions in kidney, lung, and small intestine. Injection of the rAAV- @entity11 -hAGA construct into skeletal muscle did not result in expression of @entity9 in it or in other tissues. This study provides a basis for a simple and efficient gene-therapy approach for @entity0 with @entity6 and is indicative of its potential for the treatment of other @entity7 .

title: Long-term correction of XXXX storage in Fabry @entity1 by recombinant adeno-associated virus-mediated gene transfer.

answer: @entity8


abstract: @entity6 is an @entity10 characterized by systemic and vascular accumulation of @entity8 (Gb(3)) caused by a deficiency of the lysosomal enzyme alpha-galactosidase A ( @entity9 ). The condition is associated with an increased morbidity and mortality due to @entity3 , @entity4 , and early onset of @entity2 . Hemizygous males are primarily affected clinically with variable expression in heterozygous females. Gene-therapy trials have been initiated recently in @entity9 knockout @entity1 models of @entity6 by using a variety of viral vectors. In the present investigation we administered single i.v. injections of 1 x 10(10) genomes of recombinant adeno-associated virus (rAAV) encoding the @entity0 @entity9 gene driven by a modified @entity5 @entity11 promoter to @entity9 knockout (Fabry) @entity1 . @entity1 were analyzed for expression of @entity9 activity and Gb(3) levels in liver, kidney, heart, spleen, small intestine, lung, and brain. Administration of the rAAV- @entity11 -hAGA vector resulted in stable expression of @entity9 in organs of the Fabry @entity1 for >6 months. @entity9 activity in the organs became equal to or higher than that of wild-type @entity1 . Accumulated Gb(3) in the liver, heart, and spleen was reduced to that of wild-type @entity1 with lesser but significant reductions in kidney, lung, and small intestine. Injection of the rAAV- @entity11 -hAGA construct into skeletal muscle did not result in expression of @entity9 in it or in other tissues. This study provides a basis for a simple and efficient gene-therapy approach for @entity0 with @entity6 and is indicative of its potential for the treatment of other @entity7 .

title: Long-term correction of @entity8 storage in Fabry XXXX by recombinant adeno-associated virus-mediated gene transfer.

answer: @entity1


abstract: STUDY OBJECTIVE: To estimate the clinical significance of pouch of Douglas (POD) obliteration in @entity0 undergoing laparoscopic excision of @entity1 . DESIGN: Prospective study (Canadian Task Force Classification II-2). SETTING: University-affiliated tertiary referral center for @entity1 . @entity0 : A total of 454 consecutive @entity0 who underwent laparoscopic surgery for treatment of pelvic @entity2 or @entity3 -associated @entity1 between October 2004 and September 2008. INTERVENTIONS: Demographic, historical, and final surgical data were compared between @entity0 with and without POD obliteration at laparoscopy. Logistic regression analyses were performed to investigate the predictive value of POD obliteration at laparoscopy with regard to bowel @entity1 . MEASUREMENTS AND MAIN RESULTS: One hundred consecutive @entity0 with POD obliteration at laparoscopy were included. 58% (95% confidence interval [CI] 0.48-0.67, n = 58/100) of the @entity0 with POD obliteration required bowel surgery compared with 20% (95% CI 0.16-0.25, 72/354) of @entity0 without POD obliteration (p <.001). Of the POD obliteration group, 66% (95% CI 0.53-0.76) required bowel shaving, 12% (0.06-0.23) full segmental rectal resection, 9% (0.04-0.19) wedge rectal resection, 5% (0.02-0.14) full segmental rectosigmoid resection and 9% (0.04-0.19) a combination of the above. Bowel @entity1 was histologically confirmed in all @entity0 . CONCLUSION: POD obliteration at laparoscopy carries a high risk of bowel @entity1 and bowel surgery. This risk is three times higher than those without POD obliteration. @entity0 with POD obliteration should be managed in tertiary referral centers for the treatment of @entity1 where colorectal input is available.

title: Is pouch of Douglas obliteration a marker of bowel XXXX ?

answer: @entity1


abstract: Metastasizing @entity3 are rare; thus, currently there is no uniform treatment guideline. Chemotherapeutic drugs that selectively target @entity2 -promoting pathways may complement conventional therapeutic approaches. We performed immunohistochemistry ( @entity4 ( @entity4 ), @entity8 , and @entity9 ), @entity4 and @entity8 fluorescence in situ hybridization (FISH), and multiplexed SNaPshot   genotyping (testing for recurrent mutations in 15 @entity2 genes including @entity5 , @entity4 , @entity7 , @entity11 , and @entity6 ) on @entity2 and corresponding @entity1 of 14 metastasizing @entity3 (three apocrine, six eccrine, two hidradenocarcinomas, two @entity12 , and one @entity10 ). @entity1 to regional lymph node was most common, followed by skin and then lungs. Follow-up was available in 12 @entity0 (5 months to 8   years) with 1 died of widespread @entity1 . Although @entity4 overexpression was a prevalent feature in this cohort, seen in 7/11 (64%) @entity2 and 10/14 (71%) @entity1 ; FISH for @entity4 gene amplification was negative in 9 tested @entity2 and 12 @entity1 . FISH of the one @entity2 and three @entity1 with 2+ @entity8 overexpression revealed a low level of @entity8 gene amplification in one @entity3 and corresponding @entity1 . @entity9 expression was seen only in rare cases. @entity11 (2/12, 17%) and @entity6 (3/12, 25%) mutations were detected in two (one hidradenocarcinoma, @entity12 ) and three (one eccrine, one hidradenocarcinoma, and one @entity10 ) cases, respectively. The role of @entity4 inhibitor therapy in metastasizing @entity3 with protein overexpression remains unclear. Targeted therapy including PI3K pathway inhibitors might be a potential treatment for rare cases of @entity3 with @entity1 .

title: A potential role for targeted therapy in a subset of metastasizing XXXX .

answer: @entity3


abstract: Blood vessels normally maintain stereotyped lumen diameters and their stable structures are crucial for vascular function. However, very little is known about the molecular mechanisms controlling the maintenance of vessel diameters and the integrity of endothelial cells. We investigated this issue in @entity3 embryos by a chemical genetics approach. Small molecule libraries were screened using live Tg(kdrl:GRCFP)(zn1) transgenic embryos in which endothelial cells are specifically labeled with GFP. By analyzing the effects of compounds on the morphology and function of embryonic blood vessels after lumen formation, @entity6 , a putative @entity4 kinase inhibitor, was identified as capable of specifically reducing vascular lumen size by interrupting endothelial-cell integrity. The inhibitory effect is not due to @entity4 or general VEGF signaling inhibition because another @entity4 inhibitor and @entity4 morpholino as well as several @entity1 inhibitors failed to produce a similar phenotype. After profiling a panel of 22 representative @entity0 kinases and surveying published data, we selected a few possible new candidates. Combinational analysis of these candidate kinase inhibitors established that @entity6 induced endothelial collapse by inhibiting both the @entity1 and MAP kinase pathways. More importantly, combinatory use of two clinically approved drugs @entity5 and @entity2 produced the same phenotype. This is the first study to elucidate the pathways controlling maintenance of endothelial integrity using a chemical genetics approach, indicating that endothelial integrity is controlled by the combined action of the @entity1 and MAP kinase pathways. Our results also suggest the possible side effect of the combination of two anticancer drugs on the circulatory system.

title: Combinatory action of XXXX and MAP kinase pathways maintains endothelial-cell integrity.

answer: @entity1


abstract: @entity0 telomeres are bound and protected by protein complexes assembled around the six core telomeric proteins @entity5 , @entity3 , @entity4 , @entity1 , @entity6 , and @entity2 . The function of these proteins on telomeres has been studied extensively. Recently, increasing evidence has suggested possible roles for these proteins outside of telomeres. However, the non-canonical (extra-telomeric) function of @entity0 telomeric proteins remains poorly understood. To this end, we systematically investigated the binding sites of telomeric proteins along @entity0 chromosomes, by performing whole-genome chromatin immunoprecipitation (ChIP) for @entity5 and @entity4 . ChIP sequencing (ChIP-seq) revealed that @entity5 and @entity4 could be found on a small number of interstitial sites, including regions that are proximal to genes. Some of these binding sites contain short telomere repeats, suggesting that telomeric proteins could directly bind to interstitial sites. Interestingly, only a small fraction of the available interstitial telomere repeat-containing regions were occupied by @entity5 and @entity4 . Ectopically expressed @entity4 was able to occupy additional interstitial telomere repeat sites, suggesting that protein concentration may dictate the selective targeting of telomeric proteins to interstitial sites. Reducing @entity5 and @entity4 expression by RNA interference led to altered transcription of @entity5 - and @entity4 -targeted genes. Our results indicate that @entity0 telomeric proteins could occupy a limited number of interstitial sites and regulate gene transcription.

title: XXXX telomeric proteins occupy selective interstitial sites.

answer: @entity0


abstract: Endothelium-dependent responses are impaired in various models of @entity3 . The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant @entity1 (DR) on a high or low @entity7 diet. The @entity1 were given either a diet containing 8% @entity6 or 0.1% @entity6 for 8 weeks or a diet containing 8% @entity6 and a combination of @entity11 , @entity4 , and @entity10 for 8 or 2 weeks. DS on the 8% @entity6 diet developed @entity3 , while the other @entity1 did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed @entity3 in DS and lowered blood pressure in DR on the 8% @entity6 diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, @entity5 , @entity8 , and @entity12 caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% @entity6 compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, @entity9 . These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of @entity2 in @entity0 with @entity3 .

title: Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in @entity1 with salt-induced XXXX .

answer: @entity3


abstract: Endothelium-dependent responses are impaired in various models of @entity3 . The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant @entity1 (DR) on a high or low @entity7 diet. The @entity1 were given either a diet containing 8% @entity6 or 0.1% @entity6 for 8 weeks or a diet containing 8% @entity6 and a combination of @entity11 , @entity4 , and @entity10 for 8 or 2 weeks. DS on the 8% @entity6 diet developed @entity3 , while the other @entity1 did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed @entity3 in DS and lowered blood pressure in DR on the 8% @entity6 diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, @entity5 , @entity8 , and @entity12 caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% @entity6 compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, @entity9 . These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of @entity2 in @entity0 with @entity3 .

title: Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in XXXX with salt-induced @entity3 .

answer: @entity1


abstract: @entity4 ( @entity4 ) has been generally given only by intravascular injection. Recently, an oral @entity4 named @entity5 has been developed. @entity5 is a potent inhibitor of @entity3 as well as a strong vasodilator, and its half-life in @entity0 is extremely prolonged because it is not metabolized in the lungs. Leg ulceration is one of the cutaneous manifestations in Beh  et's disease and sometimes is very difficult to treat. In this investigation five @entity0 having Beh  et's disease with leg @entity2 were treated with @entity5 . All of the @entity0 had the leg @entity2 for more than 2 months. Fifteen micrograms of @entity5 was given initially, and the dosage was increased to 30 micrograms whenever there were no adverse effects. All the @entity0 were soon able to tolerate the drug and increased dosage. Within 2 weeks, regeneration of granulomatous tissues was observed in all cases. Furthermore, the leg @entity2 healed within one year. Only one @entity0 developed @entity1 , but this symptom disappeared when he adjusted to the dosage. The findings strongly indicate that @entity5 is a safe and promising drug for the treatment of leg @entity2 in Beh  et's disease.

title: Oral @entity4 as a therapeutic modality for leg XXXX in Beh  et's disease.

answer: @entity2


abstract: @entity4 ( @entity4 ) has been generally given only by intravascular injection. Recently, an oral @entity4 named @entity5 has been developed. @entity5 is a potent inhibitor of @entity3 as well as a strong vasodilator, and its half-life in @entity0 is extremely prolonged because it is not metabolized in the lungs. Leg ulceration is one of the cutaneous manifestations in Beh  et's disease and sometimes is very difficult to treat. In this investigation five @entity0 having Beh  et's disease with leg @entity2 were treated with @entity5 . All of the @entity0 had the leg @entity2 for more than 2 months. Fifteen micrograms of @entity5 was given initially, and the dosage was increased to 30 micrograms whenever there were no adverse effects. All the @entity0 were soon able to tolerate the drug and increased dosage. Within 2 weeks, regeneration of granulomatous tissues was observed in all cases. Furthermore, the leg @entity2 healed within one year. Only one @entity0 developed @entity1 , but this symptom disappeared when he adjusted to the dosage. The findings strongly indicate that @entity5 is a safe and promising drug for the treatment of leg @entity2 in Beh  et's disease.

title: Oral XXXX as a therapeutic modality for leg @entity2 in Beh  et's disease.

answer: @entity4


abstract: UNASSIGNED: To evaluate the evidence of effects and safety of @entity6 on neuroprotection for preterm @entity0 who had exposure in uteri.We searched electronic databases and bibliographies of relevant papers to identify studies comparing @entity6 ( @entity7 ) with placebo or other treatments in @entity0 at high risk of @entity8 and reporting effects and safety of @entity7 for antenatal @entity0 . Then, we did this meta-analysis based on PRISMA guideline. The primary outcomes included @entity1 , @entity2 ( @entity2 ), @entity4 , and @entity9 . Secondary outcomes included various neonatal and maternal outcomes.Ten studies including 6 randomized controlled trials and 5 cohort studies, and involving 18,655 preterm @entity0 were analyzed. For the rate of moderate to severe @entity2 , @entity7 showed the ability to reduce the risk and achieved statistically significant difference (odd ratio [OR] 0.61, 95% confidence interval [CI] 0.42-0.89, P = 0.01). The comparison of mortality rate between the @entity7 group and the placebo group only presented small difference clinically, but reached no statistical significance (OR 0.92, 95% CI 0.77-1.11, P = 0.39). Summarily, the analysis of adverse effects on babies showed no margin (P>0.05). Yet for mothers, @entity7 exhibited obvious side-effects, such as @entity5 , @entity3 and so forth, but there exited great heterogeneity. @entity7 administered to @entity0 at high risk of @entity8 could reduce the risk of moderate to severe @entity2 , without obvious adverse effects on babies. Although there exit many unfavorable effects on mothers, yet they may be lessened through reduction of the dose of @entity7 and could be tolerable for mothers. So @entity7 is both beneficial and safety to be used as a neuroprotective agent for premature @entity0 before a valid alternative was discovered.

title: Effects and Safety of XXXX on Neuroprotection: A Meta-analysis Based on PRISMA Guidelines.

answer: @entity6


abstract: BACKGROUND AND PURPOSE: The baroreceptor reflex arc is important in the short-term regulation of the cardiovascular system, and small studies have reported @entity2 ( @entity5 ) after @entity1 . However, the prognostic significance of impaired @entity5 is uncertain. METHODS: One hundred twenty-four @entity0 underwent simultaneous ECG and noninvasive beat-to-beat blood pressure (BP) monitoring within 72 hours of neuroradiologically confirmed acute @entity3 . Cardiac @entity5 was assessed from the combined alpha-index by means of power spectral analysis techniques. Baseline data for @entity1 @entity0 were compared with those of a control group matched for age, sex, and casual BP. @entity0 were followed up for a median of 1508 days (range, 9 to 2656 days), and outcome was compared between @entity0 with and without impaired @entity5 . RESULTS: Median @entity5 values were significantly lower in @entity1 @entity0 than in controls (5 [interquartile range, 3.5 to 7.4] versus 6.2 [interquartile range, 4.5 to 8.3] ms/mm Hg; P=0.04). Sixty-one (33 male) @entity0 (mean age, 70.2 [SD 10.5] years) had impaired @entity5 (< or =5.0 ms/mm Hg) compared with 63 (35 male) @entity0 (mean age, 70.6 [SD 11.7] years) without impaired @entity5 (>5.0 ms/mm Hg). @entity1 @entity0 with impaired @entity5 values had a significantly poorer prognosis (28% versus 8% mortality rate during the follow-up period) although there were no differences in age, @entity1 severity, @entity1 type, or casual or 24-hour BP parameters between the 2 groups. CONCLUSIONS: Impaired cardiac @entity5 is associated with increased long-term mortality after acute @entity3 , irrespective of age, sex, @entity1 type, and BP. This may reflect @entity4 , but the mechanisms underlying this association are unknown, although therapies that improve cardiac @entity5 after @entity1 warrant further investigation.

title: Cardiac baroreceptor sensitivity predicts long-term outcome after acute XXXX .

answer: @entity3


abstract: One hundred five @entity0 treated with potentially curative surgery and adjuvant postoperative radiotherapy for @entity2 and rectosigmoid from 1973 through 1981 were reviewed. Radiation therapy was given with 18-25 MeV X rays in doses of 40-50 Gy in 5 weeks (midline dose) using AP-PA fields in 97 @entity0 . A boost of 6 to 10 Gy was directed to the area of maximum risk by anterior-posterior or perineal fields in 71 @entity0 . Local failure occurred in 15 @entity0 and was documented pathologically in 8 @entity0 , or clinically or radiologically in 7 @entity0 . The local recurrences according to the Modified Astler-Coller staging criteria were: B1: 0% (0/3); B2: 4% (1/24); B3: 31% (4/13); C1: 8% (1/12); C2: 18% (8/45); C3: 20% (1/5). Local failure after adjuvant radiotherapy versus surgery alone was compared. The comparison of local failure of combined treatment versus surgery alone, from our institution, is as follows: B2-4% vs 13%, B3-31% vs 26%, C2-18% vs 30%, and C3-20% vs 49%. Sixty-one @entity0 (58.1%) have been followed for 5 years, with a median of 73 months and a minimum of 24 months. The actuarial 5-year survival (disease-free) for the entire group is 55% and is not statistically different for the groups with negative or positive nodes. Fourteen @entity0 (13%) required surgery for small bowel complications; four others (4%) had symptomatic @entity3 treated with conservative therapy only. @entity3 occurred in 4 of 16 (25%) treated with radiation fields above L5, whereas those treated below L5 had an 11% incidence. Postoperative adjuvant radiotherapy can increase local @entity1 control compared to surgery alone. The small bowel complication rate in this series most likely reflects AP-PA treatment technique and can be decreased by the use of multiple fields with maximum shielding of the small intestine.

title: Postoperative adjuvant radiotherapy for XXXX and rectosigmoid.

answer: @entity2


abstract: Tissues including liver stiffen and acquire more extracellular matrix with @entity1 . The relationship between matrix content and stiffness, however, is non-linear, and stiffness is only one component of tissue mechanics. The mechanical response of tissues such as liver to physiological stresses is not well described, and models of tissue mechanics are limited. To better understand the mechanics of the normal and fibrotic @entity0 liver, we carried out a series of studies using parallel plate rheometry, measuring the response to compressive, extensional, and shear strains. We found that the shear storage and loss moduli G' and G" and the apparent Young's moduli measured by uniaxial strain orthogonal to the shear direction increased markedly with both progressive @entity1 and increasing compression, that livers shear strain softened, and that significant increases in shear modulus with compressional stress occurred within a range consistent with increased sinusoidal pressures in @entity2 . Proteoglycan content and integrin-matrix interactions were significant determinants of liver mechanics, particularly in compression. We propose a new non-linear constitutive model of the liver. A key feature of this model is that, while it assumes overall liver incompressibility, it takes into account water flow and solid phase compressibility. In sum, we report a detailed study of non-linear liver mechanics under physiological strains in the normal state, early @entity1 , and late @entity1 . We propose a constitutive model that captures compression stiffening, tension softening, and shear softening, and can be understood in terms of the cellular and matrix components of the liver.

title: Normal and Fibrotic XXXX Livers Demonstrate Shear Strain Softening and Compression Stiffening: A Model for Soft Tissue Mechanics.

answer: @entity0


abstract: UNASSIGNED: The intrahippocampal @entity7 @entity0 model of mesial @entity5 is increasingly being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous studies used male @entity0 for this purpose, and no study is available in this or other models of acquired @entity3 that directly compared epileptogenesis in female and male rodents. Epidemiological studies suggest that gender may affect susceptibility to @entity3 and its prognosis; therefore, one goal of this study was to investigate whether sex has an influence on latent period and epileptogenesis in the intrahippocampal @entity7 model in @entity0 . Another aspect that was examined in the present study was whether @entity0 differences in epileptogenesis exist. Finally, we examined the effects of different types of anesthesia ( @entity9 , @entity8 ) on @entity7 -induced @entity2 ( @entity2 ) and epileptogenesis. Continuous (24/7) video-EEG monitoring was used during @entity2 and the 2weeks following @entity2 as well as 4-6weeks after @entity2 . In male NMRI @entity0 with @entity9 anesthesia during @entity7 injection, @entity2 was followed by a @entity4 -free latent period of 10-14days if @entity1 ( @entity1 ) recorded from the @entity7 focus were considered the onset of @entity3 . Anesthesia with @entity8 led to a more rapid onset and higher severity of @entity2 , and not all male NMRI @entity0 exhibited a @entity4 -free latent period. Female NMRI @entity0 differed from male animals in the lack of any clear latent period, independently of anesthesia type. Furthermore, @entity1 were only rarely observed. These problems were not resolved by decreasing the dose of @entity7 or using other strains (C57BL/6, FVB/N) of female @entity0 . The present data are the first to demonstrate marked sex-related differences in the latent period following @entity6 in a rodent model of acquired @entity3 . Furthermore, our data demonstrate that the choice of anesthestic agent during @entity7 administration affects @entity2 severity and as a consequence, the latent period, which may explain some of the differences reported for this model in the literature.

title: Significant effects of sex, strain, and anesthesia in the intrahippocampal @entity7 @entity0 model of mesial XXXX .

answer: @entity5


abstract: UNASSIGNED: The intrahippocampal @entity7 @entity0 model of mesial @entity5 is increasingly being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous studies used male @entity0 for this purpose, and no study is available in this or other models of acquired @entity3 that directly compared epileptogenesis in female and male rodents. Epidemiological studies suggest that gender may affect susceptibility to @entity3 and its prognosis; therefore, one goal of this study was to investigate whether sex has an influence on latent period and epileptogenesis in the intrahippocampal @entity7 model in @entity0 . Another aspect that was examined in the present study was whether @entity0 differences in epileptogenesis exist. Finally, we examined the effects of different types of anesthesia ( @entity9 , @entity8 ) on @entity7 -induced @entity2 ( @entity2 ) and epileptogenesis. Continuous (24/7) video-EEG monitoring was used during @entity2 and the 2weeks following @entity2 as well as 4-6weeks after @entity2 . In male NMRI @entity0 with @entity9 anesthesia during @entity7 injection, @entity2 was followed by a @entity4 -free latent period of 10-14days if @entity1 ( @entity1 ) recorded from the @entity7 focus were considered the onset of @entity3 . Anesthesia with @entity8 led to a more rapid onset and higher severity of @entity2 , and not all male NMRI @entity0 exhibited a @entity4 -free latent period. Female NMRI @entity0 differed from male animals in the lack of any clear latent period, independently of anesthesia type. Furthermore, @entity1 were only rarely observed. These problems were not resolved by decreasing the dose of @entity7 or using other strains (C57BL/6, FVB/N) of female @entity0 . The present data are the first to demonstrate marked sex-related differences in the latent period following @entity6 in a rodent model of acquired @entity3 . Furthermore, our data demonstrate that the choice of anesthestic agent during @entity7 administration affects @entity2 severity and as a consequence, the latent period, which may explain some of the differences reported for this model in the literature.

title: Significant effects of sex, strain, and anesthesia in the intrahippocampal XXXX @entity0 model of mesial @entity5 .

answer: @entity7


abstract: UNASSIGNED: The intrahippocampal @entity7 @entity0 model of mesial @entity5 is increasingly being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous studies used male @entity0 for this purpose, and no study is available in this or other models of acquired @entity3 that directly compared epileptogenesis in female and male rodents. Epidemiological studies suggest that gender may affect susceptibility to @entity3 and its prognosis; therefore, one goal of this study was to investigate whether sex has an influence on latent period and epileptogenesis in the intrahippocampal @entity7 model in @entity0 . Another aspect that was examined in the present study was whether @entity0 differences in epileptogenesis exist. Finally, we examined the effects of different types of anesthesia ( @entity9 , @entity8 ) on @entity7 -induced @entity2 ( @entity2 ) and epileptogenesis. Continuous (24/7) video-EEG monitoring was used during @entity2 and the 2weeks following @entity2 as well as 4-6weeks after @entity2 . In male NMRI @entity0 with @entity9 anesthesia during @entity7 injection, @entity2 was followed by a @entity4 -free latent period of 10-14days if @entity1 ( @entity1 ) recorded from the @entity7 focus were considered the onset of @entity3 . Anesthesia with @entity8 led to a more rapid onset and higher severity of @entity2 , and not all male NMRI @entity0 exhibited a @entity4 -free latent period. Female NMRI @entity0 differed from male animals in the lack of any clear latent period, independently of anesthesia type. Furthermore, @entity1 were only rarely observed. These problems were not resolved by decreasing the dose of @entity7 or using other strains (C57BL/6, FVB/N) of female @entity0 . The present data are the first to demonstrate marked sex-related differences in the latent period following @entity6 in a rodent model of acquired @entity3 . Furthermore, our data demonstrate that the choice of anesthestic agent during @entity7 administration affects @entity2 severity and as a consequence, the latent period, which may explain some of the differences reported for this model in the literature.

title: Significant effects of sex, strain, and anesthesia in the intrahippocampal @entity7 XXXX model of mesial @entity5 .

answer: @entity0


abstract: The outcome of surgical treatment of @entity5 in forty-five adults was studied with special attention to @entity1 , function, self-image, and pulmonary function. All of the @entity0 were more than twenty-five years old at operation and had been followed for more than three years. Every @entity0 who was operated on by one of us (J. E. H.) and who met these criteria was evaluated. The magnitude of the curves averaged 66 degrees. Standardized gradations of @entity1 and function showed improvement over-all, but significant impairment remained. There was a reduction in the levels of peak and constant @entity1 , but no change in the frequency of @entity1 after operation. The number of @entity0 who were @entity1 -free after surgery was not increased. Functional impairment due to the @entity4 was lessened, and the ability to perform the common activities of daily living was improved, but no important changes in occupation or recreational activity were recorded. Correlations of @entity1 or function, or both, and the changes in either, were found with only two parameters: age at follow-up and physical occupation. Pulmonary function, as measured, did not change. Eighteen (40 per cent) of the @entity0 had a minor complication and ten (20 per cent), a major complication; there was one @entity2 , due to @entity3 , of a @entity0 who was excluded from the series. In view of the high rate of complications, the limited gains to be derived from spinal fusion should be assessed and clearly explained to @entity0 before the procedure is undertaken.

title: Results of surgical treatment of adults with XXXX .

answer: @entity5


abstract: Over a century ago the intact cortex was proposed to contribute to recovery from unilateral @entity5 , but its possible role in functional outcome has become more appreciated in recent years as a result of anatomic, metabolic and behavioral studies. Although use of the contralesional limb is naturally impaired after sensorimotor cortex injury, neural and astrocytic events in the intact hemisphere may give rise to, and may be influenced by, an enhanced ability to compensate for lost motor function. The debate is still open as to whether the neural changes are generally compensatory in nature, with activity in the homotopic cortex leading to greater capability in the nonimpaired limb, or whether they are actually a matter of reorganization in the homotopic cortex leading to connections to denervated targets in the opposite hemisphere, thus allowing the homotopic cortex to control motor programs there. Although both phenomena may occur to some degree, there is mounting evidence in support of the former view. Careful behavioral techniques have been developed that can expose compensatory tricks, and the time course of these behaviors correlates well with anatomic data. Moreover, if the intact cortex sustains a second lesion after recovery from the first, forelimb sensorimotor function specific to the first-impaired side of the body is not worsened. Partial denervation of callosal fibers coming from the injured hemisphere, plus preferential use of the good forelimb caused by a @entity3 , may increase trophic factors in the intact hemisphere. These and related events seem to provide a growth-favorable environment there that permits motor learning in the intact forelimb at a level of skill exceeding that which a normal animal can attain in the same period of time. There are anecdotal cases in @entity0 neurologic @entity0 that are consistent with these findings. For example, a colleague of the authors who sustained a unilateral infarction that rendered his dominant right hand severely impaired noticed that soon after the @entity1 he was able to use his left hand for writing and computers as well as he had ever used his right hand. Cross-midline placing tests also indicate that the structural events observed in the intact cortex may potentiate projections to the damaged hemisphere. These changes may help restore the capacity of tactile information projecting to the intact hemisphere to control limb placing in the impaired forelimb. Neural events in the injured hemisphere can be affected by behavior differently than the neural events in the intact hemisphere. Different therapeutic strategies might well be used on opposing limbs at different times after unilateral sensorimotor cortex injury to optimize recovery (and, indeed, to avoid exaggerating the insult). Finally, the details of reorganization in both hemispheres differ greatly depending on the type of @entity5 sustained (eg, in @entity1 versus @entity4 ), suggesting that an approach that considers the role of both hemispheres is likely to be beneficial in research on a broad variety of @entity2 .

title: Should the injured and intact hemispheres be treated differently during the early phases of physical restorative therapy in experimental XXXX or parkinsonism?

answer: @entity1


abstract: OBJECTIVE: To explore the extent and nature of change in cognitive-motor interference (CMI) among rehabilitating @entity1 @entity0 who showed dual-task gait decrement at initial assessment. DESIGN: Experimental, within-subjects, repeated measures design. SETTING: Rehabilitation centre for adults with acquired, nonprogressive @entity3 . SUBJECTS: Ten @entity0 with @entity1 , available for reassessment 1-9 months following their participation in a study of CMI after @entity3 . MEASURES: Median stride duration; mean word generation. METHODS: Two x one-minute walking trials, two x one-minute word generation trials, two x one-minute trials of simultaneous walking and word generation; 10-metre walking time; Barthel ADL Scale score. RESULTS: Seven out of ten @entity0 showed reduction over time in dual-task gait decrement. Three out of ten showed @entity2 . Only one showed concomitant reduction in gait and word generation decrement. CONCLUSION: Extent of CMI during relearning to walk after a @entity1 reduced over time in the majority of @entity0 . Effects were more evident in improved stride duration than improved cognitive performance. Measures of multiple task performance should be included in assessment for functional recovery.

title: Changing patterns of cognitive-motor interference (CMI) over time during recovery from XXXX .

answer: @entity1


abstract: The aim of this study was to determine the optimal stage of development at which transplant @entity0 ex vivo-produced oral mucosa equivalents (EVPOMEs) in vivo. EVPOMEs were generated in a serum-free culture system, without the use of an irradiated xenogeneic feeder layer, by seeding @entity0 oral keratinocytes onto a @entity0 cadaveric dermal equivalent, AlloDerm. EVPOMEs were cultured for 4 days submerged and then for 7 or 14 days at an air-liquid interface to initiate stratification before transplantation into @entity2 @entity1 . AlloDerm, without epithelium, was used as a control. @entity1 were killed on days 3, 10, and 21 posttransplantation. Epithelium of the transplanted EVPOMEs was evaluated with the differentiation marker keratin 10/13. Dermal microvessel ingrowth was determined by immunohistochemistry with a @entity1 vascular marker, lectin binding from Triticum @entity3 . The presence and stratification of the epithelium were correlated with revascularization of the underlying dermis. The microvessel density of AlloDerm without epithelium was less than that of EVPOMEs with an epithelial layer. Microvessel density of the dermis varied directly with the degree of epithelial stratification of the EVPOMEs. The EVPOMEs cultured at an air-liquid interface for 7 days had the optimal balance of neoangiogenesis and epithelial differentiation necessary for in vivo grafting.

title: Evaluation of transplanted tissue-engineered oral mucosa equivalents in severe combined immunodeficient XXXX .

answer: @entity1


abstract: BACKGROUND: Shiga toxin (Stx) is the primary virulence factor of Stx-producing @entity3 (STEC). STEC can produce @entity4 and/or Stx2a, which are antigenically distinct. However, Stx2a-producing STEC are associated with more severe disease than strains producing both @entity4 and Stx2a. METHODS AND RESULTS: To address the hypothesis that the reason for the association of Stx2a with more severe disease is because Stx2a crosses the intestinal barrier with greater efficiency that @entity4 , we covalently labeled @entity4 and Stx2a with @entity5 and determined the ex vivo fluorescent intensity of @entity0 systemic organs after oral intoxication. Surprisingly, both Stxs exhibited similar dissemination patterns and accumulated in the kidneys. We next cointoxicated @entity0 to determine whether @entity4 could impede Stx2a. Cointoxication resulted in increased survival and an extended mean time to @entity2 , compared with intoxication with Stx2a only. The survival benefit was dose dependent, with the greatest effect observed when 5 times more @entity4 than Stx2a was delivered, and was amplified when @entity4 was delivered 3 hours prior to Stx2a. Cointoxication with an @entity4 active site toxoid also reduced Stx2a @entity1 . CONCLUSIONS: These studies suggest that @entity4 reduces Stx2a-mediated @entity1 , a finding that may explain why STEC that produce only Stx2a are associated with more severe disease than strains producing @entity4 and Stx2a.

title: Shiga Toxin (Stx) Type 1a Reduces the XXXX of Stx Type 2a.

answer: @entity1


abstract: BACKGROUND: Diagnostic and surgical management of severe chronic angle- closure @entity1 secondary to ciliary body cysts can be difficult to manage in a @entity0 with @entity2 . CASE PRESENTATION: A 6-year old @entity0 with @entity2 , with progressive chronic angle- closure @entity1 secondary to ciliary body cysts presented to our clinic. The initial examination revealed counting fingers vision in the left eye. Intraocular pressure (IOP), as assessed by tonopen, was 31  mm Hg. Ultrasound biomicroscopy revealed ciliary body cysts in the left eye, and gonioscopy confirmed chronic angle closure. A tube shunt was placed to control the elevated IOP. A year after her tube shunt placement in the left eye, ultrasound biomiscropy was performed on her right eye and showed no ciliary body cysts. Gonioscopy in the right eye revealed an open angle to the ciliary body band. Subsequent serial gonioscopy every 3  months showed gradual narrowing of the right eye angle and finally three-and-a-half years after tube placement of the left eye, her right eye IOP became uncontrolled with medications alone and a tube shunt was similarly placed in the right eye. Intraoperative ultrasound biomicroscopy performed at the time of the right eye tube shunt revealed extensive ciliary body cysts in the right eye. Her IOP in both eyes have been well controlled since the placement of tube shunts. CONCLUSIONS: This is one of the first reported cases of severe chronic angle- closure @entity1 secondary to ciliary body cysts in a @entity0 with @entity2 . We believe that early screening for ciliary body cysts is important in @entity0 with @entity2 .

title: Case report: imaging and treatment of ophthalmic manifestations in XXXX .

answer: @entity2


abstract: The purpose of this study was to investigate the biomagnetic activity emitted from the prostate gland and to differentiate cancerous from benign @entity4 with the use of biomagnetic measurement and non-linear analysis. Magnetic recordings were obtained from 47 @entity0 with @entity4 . Histology revealed 24 @entity2 @entity0 and 23 @entity3 ( @entity3 ) @entity0 . The superconducting quantum interference device (SQUID) biomagnetometer was used to measure the prostate's magnetic field by placing the SQUID detector 3 mm above the symphysis pubis. The magnetic field recorded in the 2-7 Hz frequency range was of high amplitude in most malignant lesions whereas all benign cases were of low amplitude. According to our results, the sensitivity, specificity, positive predictive value and negative predictive value were 83.33%, 100%, 100% and 85.18%, respectively. By applying the Grassberger-Procaccia algorithm to the magnetoprostatogram time series in malignant and benign @entity4 we found clear saturation in @entity4 with m>7 whereas in the benign lesions there was not clear saturation. @entity2 emits higher biomagnetic activity than the @entity3 . This confirms a higher angiogenic activity in @entity2 than the @entity3 lesions. Furthermore, the saturation value in the estimation of the correlation dimension of the attractor for the @entity1 confirms the lower complexity of the system in comparison to the @entity3 , which is characterized by higher complexity.

title: Differential diagnosis of XXXX with the use of biomagnetic measurements and non-linear analysis.

answer: @entity4


abstract: Manometric assessment was performed in 54 @entity0 with congenital ano-rectal anomalies including those with a blindly ending rectum (6 cases) or with an ectopic bowel outlet either in the perineum (25 cases), vulva (8 cases), vagina (8 cases), urethra (5 cases) or bladder (2 cases). @entity0 with an externally accessible orifice were investigated preoperatively whereas those with an internal orifice or no orifice could only be evaluated after surgical correction. In all operated cases presented, the ectopic rectal opening was preserved together with its surrounding smooth musculature. It was transplanted ventral to the puborectalis sling into the anal dimple if present. A normal functioning internal sphincter was observed in all @entity0 even after transplantation. Anal resting tone was normal in all cases with mean values in the various subgroups ranging from 32 +/- 10 mmHg to 51 +/- 6 mm Hg. Frequency of anal slow pressure wave activity ranged from 11.6 +/- 1.5/min to 15.7 +/- 1.3/min. The recto-anal inhibitory reflex was present in all cases. The term @entity1 should be reserved for morphologically and physiologically abnormal microscopic communications. Failure to appreciate the presence of a normal internal sphincter may account for poor functional results after surgery. The results demonstrate the importance of preserving the internal sphincter in surgical correction of @entity2 .

title: Internal sphincter-saving in imperforate anus with or without XXXX . A manometric study.

answer: @entity1


abstract: OBJECTIVE: To determine incidence of @entity2 resistan enterococcus (VRE) colonization in our neonatal intensive care unit (NICU) over five-year period, rate of progression to @entity1 and associated risk factors. METHODS: A retrospective analysis of a prospective surveillance for VRE colonization and health care associated infections was made. Contact precautions were taken against colonization, although the application varied over the years due to repairs in the unit. RESULTS: VRE rectal colonization was detected in 200/1671 neonates (12%) admitted to NICU. It showed great interannual variability from 1.9% to 30.3%. @entity1 developed in 6/200 VRE colonized @entity0 (3%) within a median of 9 days (range:3-58 days). The risk factors for @entity1 development identified in the univariate analysis were long hospital stay (>= 30 days), @entity4 , surgical procedure, extraventricular drainage, receipt of @entity3 and receipt of glycopeptides after detection of VRE colonization. Crude in-hospital mortality was higher in neonates who developed a systemic @entity1 (p<0.001). CONCLUSION: Maintaining physical conditions in the unit favorable for infection control and rational use of antibiotics are essential in control of VRE colonization and resultant infections. Special attention should be directed to VRE colonized babies carrying the risk factors.

title: XXXX Resistant Enterococci Colonization in a Neonatal Intensive Care Unit: Who will be infected?

answer: @entity2


abstract: @entity1 -PAGE of the 190 @entity4 of Helminthosporium victoriae, using a discontinuous buffer system, revealed two major capsid polypeptides of mol. wt. 88K and 83K (p88 and @entity3 ) and a minor polypeptide, @entity5 . Peptide mapping by both limited proteolysis and selective chemical cleavage showed @entity3 and @entity5 to be closely related to p88. The origin of @entity3 / @entity5 could not be explained by proteolysis of p88 during virus preparation and storage. In @entity0 reticulocyte lysates, denatured dsRNA directed the synthesis of a single major translation product which was identical to capsid polypeptide p88 on the basis of coelectrophoresis, immunoprecipitation and peptide mapping. No translation products comparable in size to @entity3 or @entity5 were detected in vitro. These data indicated that the capsid of the 190 @entity4 is encoded by a single gene and verified the classification of the virus as a member of the family Totiviridae. Radioiodination of intact virus under conditions considered optimum for surface-specific iodination showed p88 to be more readily available for labelling than @entity3 or @entity5 . Furthermore, when Western blots of capsid polypeptides were reacted with an antiserum to @entity2 -stabilized virus (190S-G), p88 was more reactive to 190S-G antibodies than was @entity3 / @entity5 . These results suggest p88 is external to @entity3 / @entity5 in the capsid.

title: The capsid polypeptides of the 190 XXXX of Helminthosporium victoriae.

answer: @entity4


abstract: This work was initiated by the discrepancy existing between the traditional experimental @entity6 model with occlusion of one single major coronary artery in the otherwise healthy myocardium and the clinical situation in which two or more major coronary arteries are stenosed at the same time. A model mimicking this latter clinical situation was elaborated as follows: In anaesthetized, open-chest @entity0 the haemodynamic, electrophysiological and blood flow changes due to 5 min occlusion of the left anterior descending coronary artery ( @entity8 ) were studied in the absence and presence of a critical constriction of the left circumflex coronary artery (LCX). Control @entity2 resulted in enhanced ST-segment elevation and inhomogeneity of electrical activation, depressed left ventricular contractility (LVdP/dt) and local myocardial contractility, as well as in a decline of @entity1 ( @entity1 ) in the ischaemic area supplied by @entity8 . These changes were accompanied by no or slight extrasystolic activity. In the presence of critical @entity4 of LCX, occlusion of the @entity8 aggravated @entity1 , i.e. ST-segment elevation and diminution of @entity1 were more marked, mainly in the subepicardium of the ischaemic area. The incidence and severity of @entity5 significantly increased. Even @entity7 occurred in one third of the animals, both during @entity2 and after its release. Thus, acute @entity2 in the presence of a stenosed LCX produced a more severe @entity1 associated with more severe @entity5 than occlusion of @entity8 alone. This model is more relevant to the clinical situation in which multivessel @entity3 is common.

title: Effect of the blood supply to the normal noninfarcted myocardium on the incidence and severity of early post-occlusion XXXX in @entity0 .

answer: @entity5


abstract: This work was initiated by the discrepancy existing between the traditional experimental @entity6 model with occlusion of one single major coronary artery in the otherwise healthy myocardium and the clinical situation in which two or more major coronary arteries are stenosed at the same time. A model mimicking this latter clinical situation was elaborated as follows: In anaesthetized, open-chest @entity0 the haemodynamic, electrophysiological and blood flow changes due to 5 min occlusion of the left anterior descending coronary artery ( @entity8 ) were studied in the absence and presence of a critical constriction of the left circumflex coronary artery (LCX). Control @entity2 resulted in enhanced ST-segment elevation and inhomogeneity of electrical activation, depressed left ventricular contractility (LVdP/dt) and local myocardial contractility, as well as in a decline of @entity1 ( @entity1 ) in the ischaemic area supplied by @entity8 . These changes were accompanied by no or slight extrasystolic activity. In the presence of critical @entity4 of LCX, occlusion of the @entity8 aggravated @entity1 , i.e. ST-segment elevation and diminution of @entity1 were more marked, mainly in the subepicardium of the ischaemic area. The incidence and severity of @entity5 significantly increased. Even @entity7 occurred in one third of the animals, both during @entity2 and after its release. Thus, acute @entity2 in the presence of a stenosed LCX produced a more severe @entity1 associated with more severe @entity5 than occlusion of @entity8 alone. This model is more relevant to the clinical situation in which multivessel @entity3 is common.

title: Effect of the blood supply to the normal noninfarcted myocardium on the incidence and severity of early post-occlusion @entity5 in XXXX .

answer: @entity0