abstract: UNASSIGNED: @entity4 en coup the sabre (LSCS), progressive @entity6 (PFH) and @entity7 are distinct clinical entities, although @entity0 with overlapping features have been reported. We performed a multicenter retrospective review of a series of @entity0 with LSCS and/or PFH to explore the relation between these entities. The files of 16 @entity0 were reviewed, 11 presented with LSCS, 5 with PFH, with time overlapping cutaneous features were seen. Extracutaneous signs were found in both groups. ANA were present in more than 50  % of @entity0 . Almost half of our @entity0 presented with CNS manifestations comprising @entity1 , @entity5 and @entity3 with or without abnormalities on MRI. Brain biopsy in one @entity0 was consistent with @entity2 . In two other @entity0 , associated autoimmune manifestations were present. CONCLUSION: Our @entity0 cohort brings more arguments to consider LSCS and PFH as a single disease entity with LSCS and superficial skin involvement at one end of the spectrum and PFH with involvement of subcutaneous deep tissue at the other end. In both entities, @entity2 can be observed. Our findings of circulating ANA, intradermal lymphocytes and IgG, intrathecal IgG production and clinical improvement with immunosuppressive therapy endorse the concept of a possible common immune-inflammatory pathogenesis. What is known:     LSCS, PFH and immune-inflammatory @entity2 are distinct clinical entities, but @entity0 with overlapping features have been reported. What is new:     We present a unique paediatric cohort with LSCS, PFH and/or @entity2 .     We endorse the concept of a common immune-inflammatory disease process.

title: Overlap between @entity4 , progressive XXXX and immune-inflammatory @entity2 in a paediatric cohort.

answer: @entity6


abstract: @entity3 is a major environmental pollutant and a proven teratogen in @entity0 and animals. Its teratogenicity and effects on fetal chromosomes were investigated in @entity1 . Various dose levels of @entity5 ( @entity4 ) were administered via an intragastric tube to pregnant ICR Swiss/Webster @entity1 on day 9 of gestation. On day 18 of gestation the animals were killed and the fetuses were removed. Fetal lung and liver tissues were processed for cytogenetic studies. Fetuses were also fixed in Bouin's solution for subsequent teratological examination by using Wilson's technique. @entity3 levels were determined in maternal blood and randomly selected fetuses. One fetus from each litter was processed for skeletal staining with @entity6 . A significant @entity2 and resorptions was observed at all dose levels. The incidence of fetal anomalies was significantly increased following maternal treatment with 10, 15, or 20 mg/kg of @entity4 . Maternal weight between day 9 and day 18 of gestation decreased significantly. The LD50 of @entity4 in pregnant @entity1 was determined to be 20 mg/kg of body weight; the LD100 was 30 mg/kg. A significant difference was observed between the mean fetal weights at the various dose levels. Levels of @entity3 were found to be significantly higher in treated animals and fetuses, and increased in a dose-related manner. The levels of @entity3 were significantly higher in the fetuses than in the mothers at the same dosage, indicating a correlation between the levels of @entity3 in maternal @entity1 and corresponding higher levels in their fetuses. Cytogenetic studies revealed significant clumping of chromosomes in metaphase at all dose levels and the frequency of clumping increased as dosage increased. The euploidy number (2n = 40) of chromosomes per cell did not vary between the treatment groups and control groups. The frequency of nucleolus-organizing regions per cell did not change significantly between the treatment groups and the control. The frequency of sister chromatid exchanges increased significantly as the dosage increased.

title: In vivo evaluation of teratogenesis and cytogenetic changes following XXXX treatment.

answer: @entity5


abstract: PURPOSE: To report the safety and short-term efficacy of endovascular interventions for symptomatic lung transplant-related anastomotic @entity4 ( @entity4 ). MATERIALS AND METHODS: From February 2008 to December 2011, 354 lung transplants were performed. Pulmonary arteriography was performed in 19 @entity0 (63% @entity0 ; age, 57 y    21, mean    SD; seven double-lung transplants) because of @entity6 (mean 6.7 mo after transplant). Seven arteriograms were normal, and 12 showed significant @entity4 . One @entity0 (5%) underwent angioplasty alone, and 11 @entity0 (57%) underwent stent placement. RESULTS: All @entity0 underwent general anesthesia, and femoral access was used for the intervention. Technical success was 100% in the 12 @entity0 treated. Symptoms improved in all @entity0 who underwent intervention, with resolution in 11 of 12 (92%). There were no major or minor complications. Three @entity0 (16%) had recurrent symptoms after discharge secondary to chronic rejection or @entity1 . Two @entity0 died as a result of @entity3 and @entity2 at 2 days and 14 days, respectively, after undergoing only pulmonary arteriography. In-stent @entity5 occurred in 1 (9%) @entity0 who required additional stent placement. During a mean follow-up period of 11 months, the remaining stents were patent, and the @entity0 were asymptomatic. CONCLUSIONS: Endovascular stent placement provides an alternative to open repair for transplant-related anastomotic @entity4 . It has low mortality and morbidity rates, and it has shown excellent short-term functional and anatomic outcomes.

title: Endovascular Management of Early Lung Transplant-Related XXXX .

answer: @entity4


abstract: Allograft vasculopathy (AV) causes intimal thickening with progressive @entity4 , @entity2 , and abnormal vasomotion. Subendocardial vacuolization indicating ongoing @entity1 was observed at autopsy in transplanted hearts with severe AV. Whether myocyte vacuolization can be observed with lesser degrees of AV in cardia transplant @entity0 has not been reported. Thirty-nine cardiac transplant @entity0 without flow-limiting disease in large epicardial arteries underwent invasive assessment of AV. Eight to 10 segments of the left anterior descending artery were analyzed by intracoronary ultrasound, and an average intimal index was calculated. Endothelial response to @entity3 was assessed with serial quantitative angiography. Endomyocardial biopsies taken 5 to 7 days prior to the invasive studies were histopathologically reviewed for the presence of small intramyocardial arteries and myocyte vacuolization. Myocyte vacuolization was evident in biopsies from 20 @entity0 (51%). Intramyocardial arteries were observed in 30 cases (76%); 14 had abnormal arteries. All @entity0 had some degree of intimal thickening by intracoronary ultrasound, and 7 (17 %) had severely abnormal average intimal index (>0.2). @entity2 was present in 23 @entity0 (58%). Vacuolization failed to show an association with abnormal small artery histology or large epicardial artery ultrasound disease. However, a significant association between vacuolization and @entity2 was observed (p = 0.05). Myocyte vacuolization, possibly indicating @entity1 , is common in biopsies from cardiac transplant @entity0 and is associated with abnormal @entity3 response in large epicardial arteries. We speculate that myocyte vacuolization may be caused at least in part by impaired coronary flow associated with @entity2 .

title: Myocardial vacuolization, a marker of @entity1 , in surveillance cardiac biopsies posttransplant: Correlations with morphologic vascular disease and XXXX .

answer: @entity2


abstract: Allograft vasculopathy (AV) causes intimal thickening with progressive @entity4 , @entity2 , and abnormal vasomotion. Subendocardial vacuolization indicating ongoing @entity1 was observed at autopsy in transplanted hearts with severe AV. Whether myocyte vacuolization can be observed with lesser degrees of AV in cardia transplant @entity0 has not been reported. Thirty-nine cardiac transplant @entity0 without flow-limiting disease in large epicardial arteries underwent invasive assessment of AV. Eight to 10 segments of the left anterior descending artery were analyzed by intracoronary ultrasound, and an average intimal index was calculated. Endothelial response to @entity3 was assessed with serial quantitative angiography. Endomyocardial biopsies taken 5 to 7 days prior to the invasive studies were histopathologically reviewed for the presence of small intramyocardial arteries and myocyte vacuolization. Myocyte vacuolization was evident in biopsies from 20 @entity0 (51%). Intramyocardial arteries were observed in 30 cases (76%); 14 had abnormal arteries. All @entity0 had some degree of intimal thickening by intracoronary ultrasound, and 7 (17 %) had severely abnormal average intimal index (>0.2). @entity2 was present in 23 @entity0 (58%). Vacuolization failed to show an association with abnormal small artery histology or large epicardial artery ultrasound disease. However, a significant association between vacuolization and @entity2 was observed (p = 0.05). Myocyte vacuolization, possibly indicating @entity1 , is common in biopsies from cardiac transplant @entity0 and is associated with abnormal @entity3 response in large epicardial arteries. We speculate that myocyte vacuolization may be caused at least in part by impaired coronary flow associated with @entity2 .

title: Myocardial vacuolization, a marker of XXXX , in surveillance cardiac biopsies posttransplant: Correlations with morphologic vascular disease and @entity2 .

answer: @entity1


abstract: A new approach to surgical correction of @entity2 (including @entity3 ) is advanced. A ring-shaped inlay of biologically-inert polymer is imbedded into the @entity1 in order to make its curvature steeper. The corneal tissue is displaced centripetally by constant traction around its optical zone. No corneal grafting or incision in the optical zone is required. The simplest way to carry out the procedure is to place a buried intracorneal suture in a circle 6 to 8 mm in diameter. The suture must be tied strongly enough to ensure sufficient bulging of the @entity1 inside the circle. Then it will remain buried inside the @entity1 permanently. The term "circling keratorraphy" was coined for the technique. The results of the first six procedures performed on @entity0 are presented and are considered to be promising. Some improvements in the exactness and delicacy of the technique are required; this work is currently in progress.

title: Circling keratorraphy: a new approach to surgical correction of XXXX (preliminary communication).

answer: @entity3


abstract: The irrigation is generally similar to that found in the @entity1 and the hamster. However, certain differences are found in the OF1 strain of @entity0 . The relatively slender @entity3 has a perpendicular @entity2 at the cranial extremity of the uterine artery giving rise to a more voluminous ovarian branch. The arterial @entity2 at the tubulo-uterine junction is very fine. The uterine artery always arises from the umbilical artery which in every case arose from the internal iliac artery. The uterine artery has a voluminous branch to the uterine body and the cervix but does not anastomose with the vaginal artery. The vaginal arteries are narrow and asymmetrical, the right branch always giving rise to a voluminous urethral branch. The arteries of the pelvic wall are characterised by the variability of their origin resulting from the asymmetric disposition of the internal and external iliac arteries. The venous system includes numerous anastomoses, cranial and caudal to the pubic symphysis. On the sides of the vagina, the vaginal veins form an anastomosic arcade.

title: [Blood supply to the female urogenital system and pelvis in the XXXX ].

answer: @entity0


abstract: AIM: To review the experience on depot-dose, and daily low-dose @entity4 agonist (GnRHa) long protocols and identify prognostic factors. SETTING AND DESIGN: A chart review was conducted on 2106 depot and 1299 daily low-dose cycles at a university hospital. METHODS: Clinical parameters were summarized, and prognostic factors of clinical pregnancy for each protocol were identified by logistic regressions. Missing data were imputed using @entity1 ( @entity1 ) and the regression models were rerun after @entity1 . RESULTS: Clinical pregnancy rate was 57.5% and 46.9% in the depot and daily low-dose groups, respectively. Logistic regressions with @entity1 identified age (odds ratio [OR]: 0.95, 95% confidence interval [CI]: 0.92-0.98), serum @entity2 (OR: 0.62, 95% CI: 0.45-0.84) and endometrial thickness (OR: 1.06, 95% CI: 1.02-1.12) on @entity0 @entity3 day, number of oocytes retrieved (OR: 1.04, 95% CI: 1.01-1.06), fertilization rate (OR: 2.66, 95% CI: 1.46-4.87) and ratio of good-quality D3 embryos (OR: 4.31, 95% CI: 2.79-6.67) as prognostic factors in the depot group. Age (OR: 0.95, 95% CI: 0.92-0.98), endometrial thickness on hCG day (OR: 1.09, 95% CI: 1.03-1.15), ratio of good quality D3 embryos (OR: 2.56, 95% CI: 1.59-4.13) and the number of cryopreserved embryos (OR: 1.07, 95% CI: 1.003-1.15) are prognostic for the daily low-dose protocol. Some regression coefficients that are significant under model-wise deletion become nonsignificant after @entity1 . CONCLUSIONS: Age, embryo quality and endometrial thickness on hCG day are important prognostic factors for both 1.0/1.3 mg depot and 0.05/0.1 mg daily low-dose luteal phase GnRHa long protocols. @entity1 is a valuable tool to gauge and address bias caused by missing data in reproductive medicine.

title: Prognostic factors associated with clinical pregnancy in in vitro fertilization using pituitary down-regulation with depot and daily low-dose luteal phase XXXX agonists: A single center's experience.

answer: @entity4


abstract: A simple, sensitive, inexpensive, and rapid stability indicating high performance liquid chromatographic method has been developed for determination of @entity0 in injectable dosage forms using @entity3 as internal standard. @entity1 was achieved on a Phenomenex Luna C-18 column (250   mm * 4.6   mm; 5 ) with a mobile phase consisting of 90% water and 10% @entity2 (pH 7.00    0.05). The signals of @entity0 and @entity3 were recorded at 275   nm. Calibration curves were linear in the concentration range of 0.5-50    g/mL. The correlation coefficient was 0.999 or higher. The limit of detection and limit of quantitation were 0.1498 and 0.4541    g/mL, respectively. The inter- and intraday precision were less than 2%. Accuracy of the method ranged from 100.2% to 100.4%. Stability studies indicate that the drug was stable to sunlight and UV light. The drug gives 6 different hydrolytic products under alkaline stress and 3 in acidic condition. Aqueous and oxidative stress conditions also degrade the drug. Degradation was higher in the alkaline condition compared to other stress conditions. The robustness of the methods was evaluated using design of experiments. Validation reveals that the proposed method is specific, accurate, precise, reliable, robust, reproducible, and suitable for the quantitative analysis.

title: Stability-indicating HPLC determination of XXXX in pharmaceutical formulations.

answer: @entity0


abstract: @entity2 among @entity4 @entity0 is one of the major reasons for non-attainment of 85% treatment success target set by World Health Organization. In this short paper, we evaluated whether the overall mortality rate in @entity6 is being affected by other comorbid conditions. All new smear positive @entity6 @entity0 (N =336), who started their treatment at the chest clinic of the Penang General Hospital, between March 2010 and February 2011, were followed-up until December 2011. @entity4 treatment outcomes were reported according to six treatment outcome categories recommended by World Health Organization. The outcome category 'died' was defined as 'a @entity0 who died due to @entity4 or other cause during @entity4 treatment'. Our findings showed that out of 336 smear positive @entity6 @entity0 , 59 (17.6%) died during treatment (mortality rate = 1.003 cases per 1000 @entity0 -days of follow-up). Among the deceased @entity0 , the mean age was 55.8 years (SD =16.17) and 49 were male. According to the mortality review forms, 29 @entity2 were @entity4 -related, while the remaining 30 @entity0 died due to reasons other than @entity4 . @entity1 (n =7), @entity3 shock (n =4) and @entity5 (n =4) were the most common @entity4 related reasons for mortality in the @entity0 . If the 30 @entity0 , for whom @entity4 was incidental to @entity2 , are excluded from the final cohort, the proportion of @entity0 in the 'died' outcome category could be reduced to 9.5%. The treatment outcome criterion (i.e., died) set by World Health Organization has limitations. Therefore, it requires improvement for more objective evaluation of the performance of the National @entity4 Program.

title: XXXX @entity2 : are we measuring accurately?

answer: @entity4


abstract: @entity2 among @entity4 @entity0 is one of the major reasons for non-attainment of 85% treatment success target set by World Health Organization. In this short paper, we evaluated whether the overall mortality rate in @entity6 is being affected by other comorbid conditions. All new smear positive @entity6 @entity0 (N =336), who started their treatment at the chest clinic of the Penang General Hospital, between March 2010 and February 2011, were followed-up until December 2011. @entity4 treatment outcomes were reported according to six treatment outcome categories recommended by World Health Organization. The outcome category 'died' was defined as 'a @entity0 who died due to @entity4 or other cause during @entity4 treatment'. Our findings showed that out of 336 smear positive @entity6 @entity0 , 59 (17.6%) died during treatment (mortality rate = 1.003 cases per 1000 @entity0 -days of follow-up). Among the deceased @entity0 , the mean age was 55.8 years (SD =16.17) and 49 were male. According to the mortality review forms, 29 @entity2 were @entity4 -related, while the remaining 30 @entity0 died due to reasons other than @entity4 . @entity1 (n =7), @entity3 shock (n =4) and @entity5 (n =4) were the most common @entity4 related reasons for mortality in the @entity0 . If the 30 @entity0 , for whom @entity4 was incidental to @entity2 , are excluded from the final cohort, the proportion of @entity0 in the 'died' outcome category could be reduced to 9.5%. The treatment outcome criterion (i.e., died) set by World Health Organization has limitations. Therefore, it requires improvement for more objective evaluation of the performance of the National @entity4 Program.

title: @entity4 XXXX : are we measuring accurately?

answer: @entity2


abstract: @entity1 @entity0 suspected of having disease which might interfere with good postoperative visual function were referred for evaluation. Monocular steady-state luminance visual evoked potentials (VEPs) were elicited with closed eyes at a stimulus rate of 10 flashes/sec. VEPs were rated as either normal or abnormal. @entity0 with normal VEPs were predicted to have an acuity of 6/15 (20/50) or better. @entity0 with abnormal VEPs were predicted to have acuities of 6/18 (20/60) or worse. Postoperative acuities were determined for all @entity0 who underwent surgery and who had no intraoperative or early @entity2 . The association of preoperative VEPs and observed postoperative acuities were quantitatively compared by a 2 x 2 contingency table for the 59 eyes which met these criteria. The chi-square was significant (p less than 0.001). The overall accuracy of prediction was 76%. Accuracy was 80% for @entity0 with a preoperative acuity of 6/60 (20/200) or better and 75% for those whose postoperative acuity was 6/120 (20/400) or worse. This difference was not statistically significant.

title: 10-Hz flash visual evoked potentials predict post- XXXX extraction visual acuity.

answer: @entity1


abstract: Studies of individuals with @entity1 ( @entity1 ) have detected @entity4 in the hippocampus during task-related functional magnetic resonance imaging (fMRI). Such elevated activation has been localized to the hippocampal dentate gyrus/ @entity3 (DG/ @entity3 ) during performance of a task designed to detect the computational contributions of those hippocampal circuits to episodic memory. The current investigation was conducted to test the hypothesis that greater hippocampal activation in @entity1 represents a dysfunctional shift in the normal computational balance of the DG/ @entity3 regions, augmenting @entity3 -driven pattern completion at the expense of pattern separation mediated by the dentate gyrus. We tested this hypothesis using an intervention based on animal research demonstrating a beneficial effect on cognition by reducing excess hippocampal neural activity with low doses of the atypical anti- @entity2 levetiracetam. In a within-subject design we assessed the effects of levetiracetam in three cohorts of @entity1 @entity0 , each receiving a different dose of levetiracetam. Elevated activation in the DG/ @entity3 region, together with impaired task performance, was detected in each @entity1 cohort relative to an aged control group. We observed significant improvement in memory task performance under drug treatment relative to placebo in the @entity1 cohorts at the 62.5 and 125  mg BID doses of levetiracetam. Drug treatment in those cohorts increased accuracy dependent on pattern separation processes and reduced errors attributable to an over-riding effect of pattern completion while normalizing fMRI activation in the @entity3 and entorhinal cortex. Similar to findings in animal studies, higher dosing at 250  mg BID had no significant benefit on either task performance or fMRI activation. Consistent with predictions based on the computational functions of the @entity3 elucidated in basic animal research, these data support a dysfunctional encoding mechanism detected by fMRI in individuals with @entity1 and therapeutic intervention using fMRI to detect target engagement in response to treatment.

title: Response of the medial temporal lobe network in XXXX to therapeutic intervention assessed by fMRI and memory task performance.

answer: @entity1


abstract: A field strain of @entity0 isolated in embryonated eggs during the 1984-5 influenza outbreak (A/Finland/13/85E) was compared in an antigenic analysis with virus from the same clinical specimen isolated in MDCK cell cultures (A/Finland/13/85M). The @entity2 appeared to be more sensitive to haemagglutination-inhibiting antibodies against heterologous viruses than did the @entity1 . The results of propagation and plaque purification experiments support the hypothesis that a single clinical specimen may consist of distinct antigenic variant subpopulations promoted selectively by the host during isolation procedures. Receptor-binding properties are discussed as a possible explanation for this selectivity. A set of 471 paired sera consisting of pre-epidemic and post-epidemic specimens taken from the same subjects in 1984-5 was studied for haemagglutination-inhibiting antibodies to six @entity0 strains, including the @entity1 and the @entity2 from A/Finland/13/85. Of the antigens used, the @entity2 detected significant antibody increases more frequently than did the @entity1 (10.0 v. 5.9%). The superiority of the @entity2 may rest primarily in its ability to pick out anamnestic antibody responses. Irrespective of this cross-reactivity, pre-epidemic antibody to the @entity2 was fairly well associated with protection. In the set of sera (230 specimens) collected in summer 1985 to represent different age groups, the antibody status against the @entity2 was significantly better than the status against the @entity1 . The results suggest that, at least in some instances, antibody to MDCK-grown virus is a more accurate indicator of the immune status of a community than antibodies to egg-grown virus variants.

title: Egg-grown and tissue-culture-grown variants of XXXX with special attention to their use as antigens in seroepidemiology.

answer: @entity0


abstract: BACKGROUND: @entity6 ( @entity6 ) over-expression disrupts the blood-brain barrier (BBB) in the @entity2 brain. The retinoid X receptor agonist bexarotene suppresses @entity6 expression in endothelial cells and displays neuroprotective effects. Therefore, we hypothesized that bexarotene may have a beneficial effect on I/R-induced @entity3 . METHODS: A total of 180 @entity1 were randomized into three groups (n = 60 each): (i) a sham-operation group, (ii) a @entity5 -reperfusion (I/R) group, and (iii) an I/R+bexarotene group. Brain water content was measured by the dry wet weight method. BBB permeability was analyzed by Evans Blue staining and the magnetic resonance imaging contrast agent Omniscan. @entity6 mRNA expression, protein expression, and activity were assessed by reverse transcription polymerase chain reaction, Western blotting, and gelatin zymography, respectively. @entity7 ( @entity7 ), @entity8 , and @entity4 expression were analyzed by Western blotting. RESULTS: After 24 h, 48 h, and 72 h post-I/R, several effects were observed with bexarotene administration: (i) brain water content and BBB permeability were significantly reduced; (ii) @entity6 mRNA and protein expression as well as activity were significantly decreased; (iii) @entity8 and @entity4 expression were significantly increased; and (iv) @entity7 expression was significantly increased. CONCLUSIONS: Bexarotene decreases BBB permeability in @entity1 with cerebral I/R injury. This effect may be due in part to bexarotene's upregulation of @entity7 expression, which has been previously shown to reduce BBB permeability through suppressing @entity6 -mediated degradation of the tight junction proteins @entity8 and @entity4 . This work offers insight to aid future development of therapeutic agents for cerebral I/R injury in @entity0 @entity0 .

title: Bexarotene Reduces Blood-Brain Barrier Permeability in XXXX -Reperfusion Injured @entity1 .

answer: @entity5


abstract: BACKGROUND: @entity6 ( @entity6 ) over-expression disrupts the blood-brain barrier (BBB) in the @entity2 brain. The retinoid X receptor agonist bexarotene suppresses @entity6 expression in endothelial cells and displays neuroprotective effects. Therefore, we hypothesized that bexarotene may have a beneficial effect on I/R-induced @entity3 . METHODS: A total of 180 @entity1 were randomized into three groups (n = 60 each): (i) a sham-operation group, (ii) a @entity5 -reperfusion (I/R) group, and (iii) an I/R+bexarotene group. Brain water content was measured by the dry wet weight method. BBB permeability was analyzed by Evans Blue staining and the magnetic resonance imaging contrast agent Omniscan. @entity6 mRNA expression, protein expression, and activity were assessed by reverse transcription polymerase chain reaction, Western blotting, and gelatin zymography, respectively. @entity7 ( @entity7 ), @entity8 , and @entity4 expression were analyzed by Western blotting. RESULTS: After 24 h, 48 h, and 72 h post-I/R, several effects were observed with bexarotene administration: (i) brain water content and BBB permeability were significantly reduced; (ii) @entity6 mRNA and protein expression as well as activity were significantly decreased; (iii) @entity8 and @entity4 expression were significantly increased; and (iv) @entity7 expression was significantly increased. CONCLUSIONS: Bexarotene decreases BBB permeability in @entity1 with cerebral I/R injury. This effect may be due in part to bexarotene's upregulation of @entity7 expression, which has been previously shown to reduce BBB permeability through suppressing @entity6 -mediated degradation of the tight junction proteins @entity8 and @entity4 . This work offers insight to aid future development of therapeutic agents for cerebral I/R injury in @entity0 @entity0 .

title: Bexarotene Reduces Blood-Brain Barrier Permeability in @entity5 -Reperfusion Injured XXXX .

answer: @entity1


abstract: UNASSIGNED: We report a case of a 14-year-old female with primary @entity5 . She was hospitalized after presenting with @entity4 and signs of @entity9 . There was no health antecedent or family history of @entity1 . Physical examination revealed a distended abdomen. Tenderness was elicited to palpation of the right lower quadrant. Magnetic resonance imaging of the abdomen revealed obstructive signs, with a constricting lesion in the mid-transverse colon of probable neoplastic nature. Laparoscopic segmental resection of the colon was followed by standard right hemicolectomy. A circumferential mid-transverse @entity1 was diagnosed as primary @entity2 ( @entity2 ) of signet-ring cell type, AJCC stage IIIC, Dukes' C stage. On the basis of immunohistochemistry and clinical data, hereditary nonpolyposis and hamartomatous @entity2 were excluded. Involvement of either the @entity7 , @entity6 , or @entity8 genes was ruled out by immunohistochemistry profiling and genetic testing. The @entity1 was categorized as sporadic. The possibility of activation of the Wnt signaling pathway was suspected, because of a defective turnover of the @entity12 protein. Postoperatively, the @entity0 was treated with both systemic and intra-abdominal adjuvant chemotherapy, including oxaliplatin. Between 18 and 24 months after diagnosis, @entity1 recurrences were detected. The @entity0 underwent bilateral oophorectomies for Krukenberg @entity1 and received salvage chemotherapy. Recently, additional recurrent metastatic @entity3 caused @entity11 . The retroperitoneal mass was debulked and a ureteric stent was placed. At the time of this writing, 43 months after diagnosis, the @entity0 is receiving FOLFOX chemotherapy combined with panitumumab. @entity2 of childhood is exceedingly rare, generally develops in the setting of unrecognized genetic predisposing factors to @entity1 , presents with @entity10 , is high grade, and tends to have dismal prognosis.

title: Selected Case From the Arkadi M. Rywlin International Pathology Slide Club: Carcinoma of the Transverse Colon in a Young XXXX .

answer: @entity0


abstract: OBJECTIVES: Head CT after out-of-hospital @entity1 is often obtained to evaluate intracranial pathology. Among @entity0 admitted to the PICU following pediatric out-of-hospital @entity1 , we hypothesized that loss of gray-white matter differentiation and basilar cistern and sulcal effacement are associated with mortality and unfavorable neurologic outcome. DESIGN: Retrospective, cohort study. SETTING: Single, tertiary-care center PICU. @entity0 : Seventy-eight @entity0 less than 18 years old who survived out-of-hospital @entity1 to PICU admission and had a head CT within 24 hours of return of spontaneous circulation were evaluated from July 2005 through May 2012. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Median time to head CT from return of spontaneous circulation was 3.3 hours (1.0, 6.0). Median @entity0 age was 2.3 years (0.4, 9.5). Thirty-nine @entity0 (50%) survived, of whom 29 (74%) had favorable neurologic outcome. Nonsurvivors were more likely than survivors to have 1) loss of gray-white matter differentiation (Hounsfield unit ratios, 0.96 [0.88, 1.07] vs 1.1 [1.07, 1.2]; p < 0.001), 2) basilar cistern effacement (93% vs 7%; p = 0.001; positive predictive value, 94%; negative predictive value, 59%), and 3) sulcal effacement (100% vs 0%; p  <= 0.001; positive predictive value, 100%; negative predictive value, 68%). All @entity0 with poor gray-white matter differentiation or sulcal effacement had unfavorable neurologic outcomes. Only one @entity0 with basilar cistern effacement had favorable outcome. CONCLUSIONS: Loss of gray-white matter differentiation and basilar cistern effacement and sulcal effacement are associated with poor outcome after pediatric out-of-hospital @entity1 . Select @entity0 may have favorable outcomes despite these findings.

title: Early Head CT Findings Are Associated With Outcomes After XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity0 is the most frequently diagnosed type of @entity2 among @entity1 . Mammogram is one of the most effective tools for early detection of the @entity0 . Various computer-aided systems have been introduced to detect the @entity0 from mammogram images. In a computer-aided diagnosis system, detection and segmentation of breast masses from the background tissues is an important issue. In this paper, an automatic segmentation method is proposed to identify and segment the suspicious mass regions of mammogram using a modified transition rule named maximal cell strength updation in @entity3 ( @entity3 ). In coarse-level segmentation, the proposed method performs an adaptive global thresholding based on the histogram peak analysis to obtain the rough region of interest. An automatic seed point selection is proposed using gray-level co-occurrence matrix-based sum average feature in the coarse segmented image. Finally, the method utilizes @entity3 with the identified initial seed point and the modified transition rule to segment the mass region. The proposed approach is evaluated over the dataset of 70 mammograms with mass from mini-MIAS database. Experimental results show that the proposed approach yields promising results to segment the mass region in the mammograms with the sensitivity of 92.25  % and accuracy of 93.48  %.

title: Mammogram segmentation using maximal cell strength updation in XXXX .

answer: @entity3


abstract: PURPOSE: Older @entity0 with newly diagnosed @entity2 have poor outcomes, and optimal treatment is controversial. Hypofractionated radiation therapy (HRT) is frequently used but has not been compared to @entity0 receiving standard fractionated radiation therapy (SRT) and @entity3 ( @entity4 ). METHODS AND MATERIALS: We conducted a retrospective analysis of @entity0 >= 65 years of age who received radiation for the treatment of newly diagnosed @entity2 from 1994 to 2013. The distribution of clinical covariates across various radiation regimens was analyzed for possible selection bias. Survival was calculated using the Kaplan-Meier method. Comparison of hypofractionated radiation (typically, 40 Gy/15 fractions) versus standard fractionation (typically, 60 Gy/30 fractions) in the setting of @entity3 was conducted using Cox regression and propensity score analysis. RESULTS: @entity0 received SRT + @entity4 (n=57), SRT (n=35), HRT + @entity4 (n=34), or HRT (n=9). @entity0 receiving HRT were significantly older (median: 79 vs 69 years of age; P<.001) and had worse baseline performance status (P<.001) than those receiving SRT. On multivariate analysis, older age (adjusted hazard ratio [AHR]: 1.06; 95% confidence interval [CI]: 1.01-1.10, P=.01), lower Karnofsky performance status (AHR: 1.02; 95% CI: 1.01-1.03; P=.01), @entity1 (AHR: 2.11; 95% CI: 1.23-3.61, P=.007), and radiation alone (vs SRT + @entity4 ; SRT: AHR: 1.72; 95% CI: 1.06-2.79; P=.03; HRT: AHR: 3.92; 95% CI: 1.44-10.60, P=.007) were associated with decreased overall survival. After propensity score adjustment, @entity0 receiving HRT with @entity4 had similar overall survival compared with those receiving SRT with @entity4 (AHR: 1.10, 95% CI: 0.50-2.4, P=.82). CONCLUSIONS: With no randomized data demonstrating equivalence between HRT and SRT in the setting of @entity4 for @entity2 , significant selection bias exists in the implementation of HRT. Controlling for this bias, we observed similar overall survival for HRT and SRT with concurrent @entity4 among elderly @entity0 , suggesting the need for a randomized trial to compare these regimens directly.

title: Hypofractionated versus standard radiation therapy with or without @entity3 for older XXXX @entity0 .

answer: @entity2


abstract: PURPOSE: Older @entity0 with newly diagnosed @entity2 have poor outcomes, and optimal treatment is controversial. Hypofractionated radiation therapy (HRT) is frequently used but has not been compared to @entity0 receiving standard fractionated radiation therapy (SRT) and @entity3 ( @entity4 ). METHODS AND MATERIALS: We conducted a retrospective analysis of @entity0 >= 65 years of age who received radiation for the treatment of newly diagnosed @entity2 from 1994 to 2013. The distribution of clinical covariates across various radiation regimens was analyzed for possible selection bias. Survival was calculated using the Kaplan-Meier method. Comparison of hypofractionated radiation (typically, 40 Gy/15 fractions) versus standard fractionation (typically, 60 Gy/30 fractions) in the setting of @entity3 was conducted using Cox regression and propensity score analysis. RESULTS: @entity0 received SRT + @entity4 (n=57), SRT (n=35), HRT + @entity4 (n=34), or HRT (n=9). @entity0 receiving HRT were significantly older (median: 79 vs 69 years of age; P<.001) and had worse baseline performance status (P<.001) than those receiving SRT. On multivariate analysis, older age (adjusted hazard ratio [AHR]: 1.06; 95% confidence interval [CI]: 1.01-1.10, P=.01), lower Karnofsky performance status (AHR: 1.02; 95% CI: 1.01-1.03; P=.01), @entity1 (AHR: 2.11; 95% CI: 1.23-3.61, P=.007), and radiation alone (vs SRT + @entity4 ; SRT: AHR: 1.72; 95% CI: 1.06-2.79; P=.03; HRT: AHR: 3.92; 95% CI: 1.44-10.60, P=.007) were associated with decreased overall survival. After propensity score adjustment, @entity0 receiving HRT with @entity4 had similar overall survival compared with those receiving SRT with @entity4 (AHR: 1.10, 95% CI: 0.50-2.4, P=.82). CONCLUSIONS: With no randomized data demonstrating equivalence between HRT and SRT in the setting of @entity4 for @entity2 , significant selection bias exists in the implementation of HRT. Controlling for this bias, we observed similar overall survival for HRT and SRT with concurrent @entity4 among elderly @entity0 , suggesting the need for a randomized trial to compare these regimens directly.

title: Hypofractionated versus standard radiation therapy with or without XXXX for older @entity2 @entity0 .

answer: @entity3


abstract: PURPOSE: Older @entity0 with newly diagnosed @entity2 have poor outcomes, and optimal treatment is controversial. Hypofractionated radiation therapy (HRT) is frequently used but has not been compared to @entity0 receiving standard fractionated radiation therapy (SRT) and @entity3 ( @entity4 ). METHODS AND MATERIALS: We conducted a retrospective analysis of @entity0 >= 65 years of age who received radiation for the treatment of newly diagnosed @entity2 from 1994 to 2013. The distribution of clinical covariates across various radiation regimens was analyzed for possible selection bias. Survival was calculated using the Kaplan-Meier method. Comparison of hypofractionated radiation (typically, 40 Gy/15 fractions) versus standard fractionation (typically, 60 Gy/30 fractions) in the setting of @entity3 was conducted using Cox regression and propensity score analysis. RESULTS: @entity0 received SRT + @entity4 (n=57), SRT (n=35), HRT + @entity4 (n=34), or HRT (n=9). @entity0 receiving HRT were significantly older (median: 79 vs 69 years of age; P<.001) and had worse baseline performance status (P<.001) than those receiving SRT. On multivariate analysis, older age (adjusted hazard ratio [AHR]: 1.06; 95% confidence interval [CI]: 1.01-1.10, P=.01), lower Karnofsky performance status (AHR: 1.02; 95% CI: 1.01-1.03; P=.01), @entity1 (AHR: 2.11; 95% CI: 1.23-3.61, P=.007), and radiation alone (vs SRT + @entity4 ; SRT: AHR: 1.72; 95% CI: 1.06-2.79; P=.03; HRT: AHR: 3.92; 95% CI: 1.44-10.60, P=.007) were associated with decreased overall survival. After propensity score adjustment, @entity0 receiving HRT with @entity4 had similar overall survival compared with those receiving SRT with @entity4 (AHR: 1.10, 95% CI: 0.50-2.4, P=.82). CONCLUSIONS: With no randomized data demonstrating equivalence between HRT and SRT in the setting of @entity4 for @entity2 , significant selection bias exists in the implementation of HRT. Controlling for this bias, we observed similar overall survival for HRT and SRT with concurrent @entity4 among elderly @entity0 , suggesting the need for a randomized trial to compare these regimens directly.

title: Hypofractionated versus standard radiation therapy with or without @entity3 for older @entity2 XXXX .

answer: @entity0


abstract: Staging and response criteria were initially developed for @entity3 ( @entity3 ) over 60 years ago, but not until 1999 were response criteria published for @entity4 ( @entity4 ). Revisions to these criteria for both @entity4 and @entity3 were published in 2007 by an international working group, incorporating PET for response assessment, and were widely adopted. After years of experience with these criteria, a workshop including representatives of most major international @entity2 cooperative groups and @entity1 centers was held at the 11th International Conference on @entity2 (ICML) in June, 2011 to determine what changes were needed. An Imaging Task Force was created to update the relevance of existing imaging for staging, reassess the role of interim PET-CT, standardize PET-CT reporting, and to evaluate the potential prognostic value of quantitative analyses using PET and CT. A clinical task force was charged with assessing the potential of PET-CT to modify initial staging. A subsequent workshop was help at ICML-12, June 2013. Conclusions included: PET-CT should now be used to stage FDG-avid @entity2 ; for others, CT will define stage. Whereas Ann Arbor classification will still be used for disease localization, @entity0 should be treated as limited disease [I (E), II (E)], or extensive disease [III-IV (E)], directed by prognostic and risk factors. Since symptom designation A and B are frequently neither recorded nor accurate, and are not prognostic in most widely used prognostic indices for @entity3 or the various types of @entity4 , these designations need only be applied to the limited clinical situations where they impact treatment decisions (e.g., stage II @entity3 ). PET-CT can replace the bone marrow biopsy (BMBx) for @entity3 . A positive PET of bone or bone marrow is adequate to designate advanced stage in DLBCL. However, BMBx can be considered in DLBCL with no PET evidence of BM involvement, if identification of discordant histology is relevant for @entity0 management, or if the results would alter treatment. BMBx remains recommended for staging of other histologies, primarily if it will impact therapy. PET-CT will be used to assess response in FDG-avid histologies using the 5-point scale, and included in new PET-based response criteria, but CT should be used in non-avid histologies. The definition of PD can be based on a single node, but must consider the potential for flare reactions seen early in treatment with newer targeted agents which can mimic disease progression. Routine surveillance scans are strongly discouraged, and the number of scans should be minimized in practice and in clinical trials, when not a direct study question. Hopefully, these recommendations will improve the conduct of clinical trials and @entity0 management.

title: Staging and response assessment in XXXX : the new Lugano classification.

answer: @entity2


abstract: BACKGROUND: An anterior transpetrosal approach (ATPA) is suitable for treating @entity3 . However, the limit of the ATPA is reached when the @entity1 extends posterolaterally over the internal auditory canal (IAC) along the petrous edge. In such cases, ligation of the posterior part of the @entity2 ( @entity2 ) is necessary. To  overcome this limitation, we combined the ATPA with a partial posterior petrosectomy in 8 @entity0 who had @entity5 extending posterolaterally over the IAC. METHODS: We resected only the Trautmann triangle in addition to the Kawase triangle to secure the space to ligate the posterior portion of the @entity2 . Because the tympanic cavity and bony labyrinth of the ear were not exposed, we were able to preserve hearing function and lower the risk of @entity6 . Furthermore, this approach enables easy ligation of the @entity2 and the tentorium posterior to the @entity1 attachment. This combined technique also allows visualization of the petrosal vein, which is important for surgery of the posterior fossa. RESULTS: Total and near-total @entity1 removal was achieved in 6 @entity0 (75%) with no permanent complications and no @entity6 . @entity4 was not found in any of the @entity0 who underwent this surgery. CONCLUSIONS: The ATPA combined with partial posterior petrosectomy is an effective method for removal of complicated @entity5 that extend posterolaterally over the IAC along the petrous edge.

title: Anterior Transpetrosal Approach Combined with Partial Posterior Petrosectomy for XXXX with Posterior Extension.

answer: @entity5


abstract: BACKGROUND: There is a clinical need for evidence-based psychotherapy response biomarkers in @entity2 ( @entity2 ). Based on previous studies, we hypothesized that lower 24-h urinary @entity3 levels and a history of early life stress/ @entity1 would predict an improved antidepressant response to cognitive-behavioral therapy (CBT). METHODS: 50 currently depressed @entity2 subjects were enrolled. 24-h urine was collected and measured for @entity3 levels by radioimmunoassay (RIA). Subjects were also administered early life stress/ @entity1 measures at baseline: Global Perceived Early-Life Stress (GPELS), The Early Life @entity1 Inventory (ELTI) and Klein Loss Scale (KLS). The efficacy of a twelve-week course of once-weekly CBT was evaluated by the primary outcome measure, the 24-item Hamilton Depression Rating Scale (HDRS24), at baseline and every four weeks, and the Beck Depression Inventory at baseline and weekly thereafter. 42 subjects had at least one complete follow-up visit (>= 4 weeks of CBT), and 30 subjects completed the full 12-week course. RESULTS: Baseline 24-h urinary @entity3 levels did not correlate with CBT's antidepressant response. Higher KLS scores, a measure of early life parental loss or @entity4 , correlated with delta HDRS24 (rs=-0.39, padjusted=0.05). Complementary general linear model analysis revealed enhanced CBT efficacy in @entity0 with a history of early life parental loss or @entity4 [F(1,35)=6.65, p=0.01]. LIMITATIONS: Small sample size, Treatment-na  ve population. CONCLUSIONS: Early life parental @entity4 or loss positively correlated with CBT's antidepressant efficacy in our sample and may warrant further study in larger clinical samples.

title: A history of early life parental loss or @entity4 is associated with successful cognitive-behavioral therapy in XXXX .

answer: @entity2


abstract: BACKGROUND: There is a clinical need for evidence-based psychotherapy response biomarkers in @entity2 ( @entity2 ). Based on previous studies, we hypothesized that lower 24-h urinary @entity3 levels and a history of early life stress/ @entity1 would predict an improved antidepressant response to cognitive-behavioral therapy (CBT). METHODS: 50 currently depressed @entity2 subjects were enrolled. 24-h urine was collected and measured for @entity3 levels by radioimmunoassay (RIA). Subjects were also administered early life stress/ @entity1 measures at baseline: Global Perceived Early-Life Stress (GPELS), The Early Life @entity1 Inventory (ELTI) and Klein Loss Scale (KLS). The efficacy of a twelve-week course of once-weekly CBT was evaluated by the primary outcome measure, the 24-item Hamilton Depression Rating Scale (HDRS24), at baseline and every four weeks, and the Beck Depression Inventory at baseline and weekly thereafter. 42 subjects had at least one complete follow-up visit (>= 4 weeks of CBT), and 30 subjects completed the full 12-week course. RESULTS: Baseline 24-h urinary @entity3 levels did not correlate with CBT's antidepressant response. Higher KLS scores, a measure of early life parental loss or @entity4 , correlated with delta HDRS24 (rs=-0.39, padjusted=0.05). Complementary general linear model analysis revealed enhanced CBT efficacy in @entity0 with a history of early life parental loss or @entity4 [F(1,35)=6.65, p=0.01]. LIMITATIONS: Small sample size, Treatment-na  ve population. CONCLUSIONS: Early life parental @entity4 or loss positively correlated with CBT's antidepressant efficacy in our sample and may warrant further study in larger clinical samples.

title: A history of early life parental loss or XXXX is associated with successful cognitive-behavioral therapy in @entity2 .

answer: @entity4


abstract: INTRODUCTION: Curative resection of @entity1 of the skull base is increasingly undertaken endoscopically. Hitherto the diverse histology, rarity and long natural history have made it difficult to accrue statistically robust cohorts for comparison with conventional craniofacial resection. It is now possible to make such a comparison in a large personal cohort. METHOD: Data on all cases of sinonasal malignancy undergoing endoscopic resection with curative intent over an eighteen year period were collected prospectively and analysed for survival and prognostic factors. RESULTS: There were 140 cases, 68 @entity0 and 72 @entity0 , aged 20-92 years (mean 63 yrs). Follow-up ranged from 6-184 months (mean 60 months). Eighteen different histopathologies were represented with @entity4 (36), @entity2 (33) and @entity3 (19) being the commonest. Additional radiotherapy was given in 95 cases and chemotherapy in 49. Overall survival is 84% at 5 years and 69% at 10 years. Overall disease-free survival was 77% at 5 years and 56% at ten. Overall and disease-free survival at 5 (and 10) years is, respectively, 97% and 90% for @entity4 , 79% and 68% for @entity3 and 56% and 39% for @entity2 . CONCLUSION: These results show that endoscopic resection is an alternative to conventional craniofacial resection in selected cases.

title: Endoscopic surgery for XXXX : an eighteen year experience.

answer: @entity1


abstract: UNASSIGNED: The reliability and diagnostic value of Lhermitte's sign in @entity1 ( @entity1 ) has not been fully established. The purpose of this study was to determine the clinical, neurophysiological and neuroradiological correlations of Lhermitte's sign in a cohort of @entity1 @entity0 and reassess the relevance of this phenomenon in the clinical history of the disease. A prospective study of 694 @entity0 with @entity1 and 110 age-matched healthy adults was evaluated by a structured questionnaire that included basic demographic data, age of onset, clinical characteristics of the disease, and the inquiry of Lhermitte's sign. Cranial and spinal magnetic resonance imagings (MRI) and median and tibial somatosensory evoked potentials (SSEP) were performed at the same time. One hundred and twelve (16  %) @entity0 were reported to have Lhermitte's sign; 582 (84  %) @entity0 did not experience Lhermitte's sign during their disease duration (P  <  0.026). No correlation was found between Lhermitte's sign and age, gender, EDSS, and disease duration; 88  % of @entity0 with Lhermitte's sign had a demyelinating lesion on the cervical MRI. In negative Lhermitte's sign group, 64  % @entity0 had a positive MRI. SSEP conductions were delayed in 92  % of @entity0 with positive Lhermitte's sign and in 70  % of @entity0 with negative Lhermitte's sign. Regarding the data, a significant correlation was found between MRI lesion and Lhermitte's sign (P  <  0.001), and between SSEP abnormality and Lhermitte's sign as well (P  <  0.001). This study underlines the relevance of this phenomenon with neuroradiological and neurophysiological abnormalities.

title: Reassessment of Lhermitte's sign in XXXX .

answer: @entity1


abstract: INTRODUCTION: Besides an obvious clinical involvement of the ear, nose and throat (ENT)-region in Eosinophilic Granulomatosis with @entity1 (EGPA), systematic data is sparse. Only a few case series and case reports are available that particularly describe rhinological, otological or other manifestations of EGPA in the ENT-region. Therefore, the objective of this study is to systematically describe data on ENT-region involvement in a large series of EGPA @entity0 . METHOD: EGPA @entity0 examined in the Department of Otorhinolaryngology of the Christian-Albrechts-University of Kiel between 1990 and 2010 were included in the study. Criteria for ENT-manifestation were assigned to five subgroups (history, ENT examination, audiological and rhinological diagnostic findings and cranial MRI) and documented cumulatively. EGPA @entity0 were examined in a standardized way based on the validated Ear Nose and Throat Activity Score (ENTAS) or its precursor, including audiological and rhinological diagnostic findings. MRI scans were analysed to further evaluate ENT involvement. RESULTS: A total of 95 EGPA @entity0 were included in the study. In approximately 80% of them, ENT-involvement was documented and the assumption of a frequent rhinological manifestation in @entity0 with EGPA was confirmed. Moreover, the data reveals remarkable evidence for an otological manifestation. A missing correlation between the rhinological and the otological manifestation indicates an independent autoimmune-inflammatory process for this manifestation. CONCLUSION: The data of the largest monocentric study presented here confirms the hypothesis of a frequent ENT involvement in EGPA @entity0 , in whom rhinological and otological manifestations are most common. Therefore, treatment should include long term follow-up and should be managed interdisciplinary.

title: Manifestation of eosinophilic XXXX with @entity1 in head and neck.

answer: @entity1


abstract: INTRODUCTION: Besides an obvious clinical involvement of the ear, nose and throat (ENT)-region in Eosinophilic Granulomatosis with @entity1 (EGPA), systematic data is sparse. Only a few case series and case reports are available that particularly describe rhinological, otological or other manifestations of EGPA in the ENT-region. Therefore, the objective of this study is to systematically describe data on ENT-region involvement in a large series of EGPA @entity0 . METHOD: EGPA @entity0 examined in the Department of Otorhinolaryngology of the Christian-Albrechts-University of Kiel between 1990 and 2010 were included in the study. Criteria for ENT-manifestation were assigned to five subgroups (history, ENT examination, audiological and rhinological diagnostic findings and cranial MRI) and documented cumulatively. EGPA @entity0 were examined in a standardized way based on the validated Ear Nose and Throat Activity Score (ENTAS) or its precursor, including audiological and rhinological diagnostic findings. MRI scans were analysed to further evaluate ENT involvement. RESULTS: A total of 95 EGPA @entity0 were included in the study. In approximately 80% of them, ENT-involvement was documented and the assumption of a frequent rhinological manifestation in @entity0 with EGPA was confirmed. Moreover, the data reveals remarkable evidence for an otological manifestation. A missing correlation between the rhinological and the otological manifestation indicates an independent autoimmune-inflammatory process for this manifestation. CONCLUSION: The data of the largest monocentric study presented here confirms the hypothesis of a frequent ENT involvement in EGPA @entity0 , in whom rhinological and otological manifestations are most common. Therefore, treatment should include long term follow-up and should be managed interdisciplinary.

title: Manifestation of eosinophilic @entity1 with XXXX in head and neck.

answer: @entity1


abstract: Therapy for @entity5 ( @entity5 ) is associated with excellent long-term survival rates, of 80% of more. Extended follow up has described late treatment-related @entity3 , principally secondary @entity1 , @entity2 and @entity4 . Given the young age of many @entity0 , there is a desire to offer a more personalised approach, correlated to individual tumour biology that enables treatment de-escalation in low risk @entity0 to reduce @entity3 , and treatment intensification in high risk @entity0 to reduce treatment failure. Contemporary therapeutic strategies have involved risk assessment based on staging and clinical factors. The use of functional imaging with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) as a predictive tool to identify early non-responders has been well validated and outperforms the risk stratifying International Prognostic Score (IPS). @entity5 has particularly high FDG-avidity (97-100%), with FDG-PET scanning reflecting metabolic activity and acting as a surrogate biomarker for chemosensitivity. International consensus on the methods of reporting and interpreting FDG-PET scans has enabled their use to be standardised and reproducible. Given that primary therapy fails for 15-20% of @entity0 , the use of combined FDG-PET and computerised tomography (FDG-PET/CT) to provide a response-adapted strategy to guide management is under investigation in numerous prospective clinical trials. They aim to determine whether early response scanning can be used to directly modulate subsequent therapy, through intensifying or abbreviating chemotherapy regimens and/or omitting radiotherapy. Integrated multi-modality imaging and advanced conformal planning techniques have led to the emergence of radiotherapy strategies such as involved-node radiation (INRT) that aim to optimise treatment volumes and maintain efficacy whilst lowering @entity3 . Study groups have incorporated these modalities in trial designs to assess whether a PET-directed, individualised approach can become the new standard of care.

title: Risk- and response-adapted strategies for the management of XXXX .

answer: @entity5


abstract: PURPOSE: We examined the impact of positive vascular margins in @entity0 with @entity4 @entity3 . MATERIALS AND METHODS: After excluding @entity0 with nonvascular positive margins, @entity1 , lymph node involvement, neoadjuvant therapy or nonclear cell histology, we identified 224 @entity0 with @entity2 invasion through our institutional database from 1999 to 2013. Kaplan-Meier analysis and log rank tests were used to evaluate whether positive vascular margins were associated with progression-free survival or @entity2 specific survival. RESULTS: There were 41 @entity0 (18%) with a positive vascular margin. Margin status was directly related to the level of invasion (p <0.0001). Compared to the negative vascular margin group the positive group had a significantly worse progression-free survival (p=0.01) but not @entity2 specific survival (p=0.3). Similarly the level of vascular thrombus invasion was significantly associated with worse progression-free survival (p=0.02) but not @entity2 specific survival (p=0.4). The 3-year progression-free survival was worst with inferior vena cava invasion and @entity1 (54%, 95% CI 34-70 vs 76%, 95% CI 64-85). Among @entity0 with only main renal vein thrombus, vascular margin status was not associated with progression-free survival (p=0.5) or @entity2 specific survival (p=0.2). CONCLUSIONS: In @entity0 with pT3N0/XM0 @entity3 positive vascular margins are associated with risk of disease progression. However, the risk of relapse associated with positive vascular margins is driven by the extent of vascular thrombus invasion. These findings suggest that the clinical significance of vascular margin status as currently defined in @entity4 @entity3 is minimal.

title: The Prognostic Impact of a Positive Vascular Margin on @entity4 XXXX .

answer: @entity3


abstract: PURPOSE: We examined the impact of positive vascular margins in @entity0 with @entity4 @entity3 . MATERIALS AND METHODS: After excluding @entity0 with nonvascular positive margins, @entity1 , lymph node involvement, neoadjuvant therapy or nonclear cell histology, we identified 224 @entity0 with @entity2 invasion through our institutional database from 1999 to 2013. Kaplan-Meier analysis and log rank tests were used to evaluate whether positive vascular margins were associated with progression-free survival or @entity2 specific survival. RESULTS: There were 41 @entity0 (18%) with a positive vascular margin. Margin status was directly related to the level of invasion (p <0.0001). Compared to the negative vascular margin group the positive group had a significantly worse progression-free survival (p=0.01) but not @entity2 specific survival (p=0.3). Similarly the level of vascular thrombus invasion was significantly associated with worse progression-free survival (p=0.02) but not @entity2 specific survival (p=0.4). The 3-year progression-free survival was worst with inferior vena cava invasion and @entity1 (54%, 95% CI 34-70 vs 76%, 95% CI 64-85). Among @entity0 with only main renal vein thrombus, vascular margin status was not associated with progression-free survival (p=0.5) or @entity2 specific survival (p=0.2). CONCLUSIONS: In @entity0 with pT3N0/XM0 @entity3 positive vascular margins are associated with risk of disease progression. However, the risk of relapse associated with positive vascular margins is driven by the extent of vascular thrombus invasion. These findings suggest that the clinical significance of vascular margin status as currently defined in @entity4 @entity3 is minimal.

title: The Prognostic Impact of a Positive Vascular Margin on XXXX @entity3 .

answer: @entity4


abstract: OBJECTIVE: To test the hypothesis that a safety margin may affect local @entity1 recurrence (LTR) in subsegmental chemoembolization. MATERIALS AND METHODS: In 101 @entity0 with 128 @entity2 ( @entity2 ) nodules (1-3 cm in size and  <= 3 in number), cone-beam CT-assisted subsegmental @entity3 chemoembolization was performed. Immediately thereafter, a non-contrast thin-section CT image was obtained to evaluate the presence or absence of intra-tumoral @entity3 uptake defect and safety margin. The effect of @entity3 uptake defect and safety margin on LTR was evaluated. Univariate and multivariate analyses were performed to indentify determinant factors of LTR. RESULTS: Of the 128 @entity2 nodules in 101 @entity0 , 49 (38.3%) nodules in 40 @entity0 showed LTR during follow-up period (median, 34.1 months). Cumulative 1- and 2-year LTR rates of nodules with @entity3 uptake defect (n = 27) and those without defect (n = 101) were 58.1% vs. 10.1% and 72.1% vs. 19.5%, respectively (p < 0.001). Among the 101 nodules without a defect, the 1- and 2-year cumulative LTR rates for nodules with complete safety margin (n = 52) and those with incomplete safety margin (n = 49) were 9.8% vs. 12.8% and 18.9% vs. 19.0% (p = 0.912). In multivariate analyses, ascites (p = 0.035), indistinct @entity1 margin on cone-beam CT (p = 0.039), heterogeneous @entity3 uptake (p = 0.023), and intra-tumoral @entity3 uptake defect (p < 0.001) were determinant factors of higher LTR. CONCLUSION: In @entity3 chemoembolization, the safety margin in completely lipiodolized nodule without defect will not affect LTR in small nodular HCCs.

title: Does Establishing a Safety Margin Reduce Local Recurrence in Subsegmental Transarterial Chemoembolization for Small Nodular XXXX ?

answer: @entity2


abstract: OBJECTIVE: The health locus of control is the subjective perception of control over one's health. It has been studied for years as one of several factors that determine @entity0 health-related behaviors. The aim of this study was to investigate how the @entity2 aura is associated with the health locus of control, @entity1 , and @entity3 . METHODS: @entity0 were included retrospectively, based on @entity0 records from the @entity2 monitoring unit of the Rigshospitalet University Hospital. @entity0 were asked about the presence and nature of auras in a semistructured interview. The Multidimensional Health Locus of Control Scale, Form C was used to evaluate the health locus of control. Three domains were evaluated: internal, where health is controlled by personal action; chance, where health is controlled by fate or luck; and powerful others, where health is controlled by the actions of others (e.g., doctors and parents). The Hospital Anxiety and @entity3 Scale was used to evaluate levels of @entity1 and @entity3 . RESULTS: Forty-nine @entity0 , with mean age of 38years, participated in the study. Of these, 67% reported experiencing one or more auras; i.e., subjective warning signs prior to a generalized or focal @entity4 with an @entity5 . @entity0 that could react to their aura prior to a @entity4 scored higher on the internal subscale of the Multidimensional Health Locus of Control questionnaire compared to @entity0 that could not react to their aura. CONCLUSIONS: The ability to react to an aura prior to a @entity4 correlated positively with the internal subscale of the health locus of control. However, it did not significantly correlate with the external subscales of chance and powerful others in the health locus of control. Moreover, there was no significant relation between the ability to react to an aura prior to a @entity4 and the levels of @entity1 or @entity3 .

title: XXXX and perception of self-control.

answer: @entity2


abstract: OBJECTIVES: This study aimed to raise radiologists' awareness of skeletal muscle metastases (SMM) in @entity4 ( @entity4 ) cases and to clarify their imaging appearance. METHODS: A retrospective analysis was undertaken of 21 @entity0 between 44-75 years old with 72 SMM treated from January 1990 to May 2009 at the @entity3 Anderson @entity2 Center in Houston, Texas, USA. Additionally, 37 @entity0 with 44 SMM from a literature review were analysed. RESULTS: Among the 21 @entity0 , the majority of SMM were asymptomatic and detected via computed tomography (CT). Mean @entity1 size was 18.3 mm and the most common site was the trunk muscles (83.3%). The interval between discovery of the primary @entity2 and @entity1 detection ranged up to 234 months. Peripheral enhancement (47.1%) was the most common post-contrast CT pattern and non-contrasted CT lesions were often isodense. Magnetic resonance imaging (MRI) characteristics were varied. Five lesions with available T1-weighted pre-contrast images were hyperintense to the surrounding muscle. Other organ metastases were present in 20 @entity0 . Of the 44 SMM reported in the literature, the majority were symptomatic. Average @entity1 size was 53.4 mm and only 20.5% of SMM were in trunk muscles. The average interval between @entity2 discovery and @entity1 detection was 101 months. Other organ metastases were recorded in 17 out of 29 @entity0 . CONCLUSION: SMM should always be considered in @entity0 with @entity4 , even well after primary treatment. SMM from @entity4 may be invisible on CT without intravenous contrast; contrast-enhanced studies are therefore recommended. SMM are often hyperintense to the surrounding muscle on T1-weighted MRI scans.

title: Skeletal Muscle Metastasis from XXXX : 21 cases and review of the literature.

answer: @entity4


abstract: BACKGROUND AND STUDY AIMS: The authors have successfully demonstrated that the white opaque substance (WOS) identified in @entity2 is an accumulation of minute lipid droplets on the @entity3 . It is not known whether the lipid droplets originate from externally ingested lipids (typically foods). The purpose of this study was to investigate whether the oral ingestion of foods containing emulsified fats increases the density of the WOS in @entity3 . @entity0 AND METHODS: We examined 92 gastric epithelial neoplastic lesions in 89 @entity0 . The @entity0 were given emulsified fatty foods before the procedure, and magnifying endoscopy with narrow-band imaging (M-NBI) was used to image the lesions. An increase in WOS density after the ingestion of emulsified fatty foods was defined as a positive fat-loading test result. The @entity0 were divided into the following groups: control group, no emulsified fat administered; group 1, fatty food administered 16 hours prior; group 3, fatty food administered both 16 and 4 hours prior. The proportion of positive fat-loading test results was determined in all groups. RESULTS: The rates of positive fat-loading test results were as follows: control group, 9%; group 1, 26%; group 2, 52%; group 3, 78%. The increase in the rates of positive fat-loading test results in groups 2 and 3 relative to the rate in the control group was statistically significant (chi-squared test). CONCLUSIONS: This study demonstrated for the first time that the ingestion of external lipids causes lipid droplets to aggregate in situ on the @entity2 . These results can be used to develop a novel functional endoscopy technique that harnesses the lipid absorption capacity of @entity1 .

title: Lipid is absorbed in the stomach by XXXX (adenomas and @entity1 ): a novel functional endoscopy technique.

answer: @entity3


abstract: BACKGROUND AND STUDY AIMS: The authors have successfully demonstrated that the white opaque substance (WOS) identified in @entity2 is an accumulation of minute lipid droplets on the @entity3 . It is not known whether the lipid droplets originate from externally ingested lipids (typically foods). The purpose of this study was to investigate whether the oral ingestion of foods containing emulsified fats increases the density of the WOS in @entity3 . @entity0 AND METHODS: We examined 92 gastric epithelial neoplastic lesions in 89 @entity0 . The @entity0 were given emulsified fatty foods before the procedure, and magnifying endoscopy with narrow-band imaging (M-NBI) was used to image the lesions. An increase in WOS density after the ingestion of emulsified fatty foods was defined as a positive fat-loading test result. The @entity0 were divided into the following groups: control group, no emulsified fat administered; group 1, fatty food administered 16 hours prior; group 3, fatty food administered both 16 and 4 hours prior. The proportion of positive fat-loading test results was determined in all groups. RESULTS: The rates of positive fat-loading test results were as follows: control group, 9%; group 1, 26%; group 2, 52%; group 3, 78%. The increase in the rates of positive fat-loading test results in groups 2 and 3 relative to the rate in the control group was statistically significant (chi-squared test). CONCLUSIONS: This study demonstrated for the first time that the ingestion of external lipids causes lipid droplets to aggregate in situ on the @entity2 . These results can be used to develop a novel functional endoscopy technique that harnesses the lipid absorption capacity of @entity1 .

title: Lipid is absorbed in the stomach by @entity3 (adenomas and XXXX ): a novel functional endoscopy technique.

answer: @entity1


abstract: BACKGROUND AND STUDY AIMS: Early video capsule endoscopy (VCE) may provide a high diagnostic yield and improve clinical outcomes in @entity0 with overt obscure @entity1 (OGIB); however, there is no practical recommendation for the ideal timing of VCE application in overt OGIB. Therefore, this study investigated the diagnostic yield and efficacy of VCE to assess overt OGIB with respect to the timing of application. @entity0 AND METHODS: We retrospectively enrolled @entity0 who had undergone VCE for overt OGIB between April 2004 and February 2014at a tertiary referral academic center. We included hemodynamically stable @entity0 who underwent VCE for overt OGIB after negative bidirectional endoscopy. We analyzed the diagnostic yield of VCE, therapeutic intervention rate, and length of hospital stay. RESULTS: A total of 94 @entity0 underwent VCE to assess overt OGIB. The diagnostic yields in the groups that underwent VCE <48h and >48h from the last overt OGIB were 66.7% and 40.6%, respectively (P=0.019). Therapeutic intervention was performed in 26.7% and 9.4% of @entity0 in the <48-h and >48-h groups, respectively (P=0.028). The mean lengths of hospital stay in the <48-h and >48-h groups were 5 days (95% confidence interval [CI], 4.8-7.7) and 7 days (95%CI, 6.9-10.1), respectively (P=0.039). CONCLUSIONS: Performing VCE within 2 days from the last overt OGIB results in a higher diagnostic yield, higher therapeutic intervention rate, and shorter hospital stay. Therefore, VCE application with a 48-h cutoff could improve the outcome of @entity0 with overt OGIB.

title: Efficacy and implications of a 48-h cutoff for video capsule endoscopy application in overt obscure XXXX .

answer: @entity1


abstract: BACKGROUND AND STUDY AIMS: Sessile serrated @entity3 / @entity5 (SSA/Ps) are considered precursors of @entity1 with @entity2 . However, it is still difficult to differentiate SSA/Ps from @entity5 endoscopically; therefore, the prevalence of SSA/Ps remains uncertain in clinical practice. This study aimed to clarify the proportion of SSA/Ps in endoscopically diagnosed @entity5 with @entity7 features (E-HPs). @entity0 AND METHODS: @entity0 aged >= 40 years undergoing colonoscopy for standard clinical indications at our center were prospectively enrolled between June 2013 and May 2014. During colonoscopy, 0.05% @entity4 dye was sprayed throughout the colorectum to highlight lesions. All detected lesions were diagnosed by high definition magnifying narrow-band imaging and were resected endoscopically or surgically, apart from rectosigmoid E-HPs  <=5mm. The number of rectosigmoid E-HPs <=5mm was recorded, and some were resected for use as tissue samples. RESULTS: A total of 343 @entity0 (male: 42.9%; mean age: 61.5 years) were included. Among 3838 E-HPs (distal: 96.4%) detected in 294 @entity0 , 792 were resected and analyzed. All of 21 SSA/Ps identified in 17 @entity0 were included in E-HPs, and the overall proportion of SSA/Ps in E-HPs was 2.7%. However, this proportion increased with the size of E-HPs ( <=5 mm: 0.7%; 6-9 mm: 29.0%; >= 10 mm: 70%) and was higher in the proximal colon than in the distal colorectum (10.9% vs. 0.9%). In addition, no SSA/P was found in the rectum, and no SSA/P had cytological @entity6 . CONCLUSIONS: The overall proportion of SSA/Ps in E-HPs was 2.7%, although this proportion was higher in the proximal colon and increased with the size of E-HPs. SSA/Ps were common in routine colonoscopy, with a prevalence of at least 5.0%. STUDY REGISTRATION: UMIN000010832.

title: Prospective evaluation of the proportion of sessile serrated XXXX / @entity5 in endoscopically diagnosed @entity5 with @entity7 features.

answer: @entity3


abstract: BACKGROUND AND STUDY AIMS: Sessile serrated @entity3 / @entity5 (SSA/Ps) are considered precursors of @entity1 with @entity2 . However, it is still difficult to differentiate SSA/Ps from @entity5 endoscopically; therefore, the prevalence of SSA/Ps remains uncertain in clinical practice. This study aimed to clarify the proportion of SSA/Ps in endoscopically diagnosed @entity5 with @entity7 features (E-HPs). @entity0 AND METHODS: @entity0 aged >= 40 years undergoing colonoscopy for standard clinical indications at our center were prospectively enrolled between June 2013 and May 2014. During colonoscopy, 0.05% @entity4 dye was sprayed throughout the colorectum to highlight lesions. All detected lesions were diagnosed by high definition magnifying narrow-band imaging and were resected endoscopically or surgically, apart from rectosigmoid E-HPs  <=5mm. The number of rectosigmoid E-HPs <=5mm was recorded, and some were resected for use as tissue samples. RESULTS: A total of 343 @entity0 (male: 42.9%; mean age: 61.5 years) were included. Among 3838 E-HPs (distal: 96.4%) detected in 294 @entity0 , 792 were resected and analyzed. All of 21 SSA/Ps identified in 17 @entity0 were included in E-HPs, and the overall proportion of SSA/Ps in E-HPs was 2.7%. However, this proportion increased with the size of E-HPs ( <=5 mm: 0.7%; 6-9 mm: 29.0%; >= 10 mm: 70%) and was higher in the proximal colon than in the distal colorectum (10.9% vs. 0.9%). In addition, no SSA/P was found in the rectum, and no SSA/P had cytological @entity6 . CONCLUSIONS: The overall proportion of SSA/Ps in E-HPs was 2.7%, although this proportion was higher in the proximal colon and increased with the size of E-HPs. SSA/Ps were common in routine colonoscopy, with a prevalence of at least 5.0%. STUDY REGISTRATION: UMIN000010832.

title: Prospective evaluation of the proportion of sessile serrated @entity3 / @entity5 in endoscopically diagnosed @entity5 with XXXX features.

answer: @entity7


abstract: BACKGROUND AND STUDY AIMS: Sessile serrated @entity3 / @entity5 (SSA/Ps) are considered precursors of @entity1 with @entity2 . However, it is still difficult to differentiate SSA/Ps from @entity5 endoscopically; therefore, the prevalence of SSA/Ps remains uncertain in clinical practice. This study aimed to clarify the proportion of SSA/Ps in endoscopically diagnosed @entity5 with @entity7 features (E-HPs). @entity0 AND METHODS: @entity0 aged >= 40 years undergoing colonoscopy for standard clinical indications at our center were prospectively enrolled between June 2013 and May 2014. During colonoscopy, 0.05% @entity4 dye was sprayed throughout the colorectum to highlight lesions. All detected lesions were diagnosed by high definition magnifying narrow-band imaging and were resected endoscopically or surgically, apart from rectosigmoid E-HPs  <=5mm. The number of rectosigmoid E-HPs <=5mm was recorded, and some were resected for use as tissue samples. RESULTS: A total of 343 @entity0 (male: 42.9%; mean age: 61.5 years) were included. Among 3838 E-HPs (distal: 96.4%) detected in 294 @entity0 , 792 were resected and analyzed. All of 21 SSA/Ps identified in 17 @entity0 were included in E-HPs, and the overall proportion of SSA/Ps in E-HPs was 2.7%. However, this proportion increased with the size of E-HPs ( <=5 mm: 0.7%; 6-9 mm: 29.0%; >= 10 mm: 70%) and was higher in the proximal colon than in the distal colorectum (10.9% vs. 0.9%). In addition, no SSA/P was found in the rectum, and no SSA/P had cytological @entity6 . CONCLUSIONS: The overall proportion of SSA/Ps in E-HPs was 2.7%, although this proportion was higher in the proximal colon and increased with the size of E-HPs. SSA/Ps were common in routine colonoscopy, with a prevalence of at least 5.0%. STUDY REGISTRATION: UMIN000010832.

title: Prospective evaluation of the proportion of sessile serrated @entity3 / XXXX in endoscopically diagnosed @entity5 with @entity7 features.

answer: @entity5


abstract: BACKGROUND AND STUDY AIMS: Sessile serrated @entity3 / @entity5 (SSA/Ps) are considered precursors of @entity1 with @entity2 . However, it is still difficult to differentiate SSA/Ps from @entity5 endoscopically; therefore, the prevalence of SSA/Ps remains uncertain in clinical practice. This study aimed to clarify the proportion of SSA/Ps in endoscopically diagnosed @entity5 with @entity7 features (E-HPs). @entity0 AND METHODS: @entity0 aged >= 40 years undergoing colonoscopy for standard clinical indications at our center were prospectively enrolled between June 2013 and May 2014. During colonoscopy, 0.05% @entity4 dye was sprayed throughout the colorectum to highlight lesions. All detected lesions were diagnosed by high definition magnifying narrow-band imaging and were resected endoscopically or surgically, apart from rectosigmoid E-HPs  <=5mm. The number of rectosigmoid E-HPs <=5mm was recorded, and some were resected for use as tissue samples. RESULTS: A total of 343 @entity0 (male: 42.9%; mean age: 61.5 years) were included. Among 3838 E-HPs (distal: 96.4%) detected in 294 @entity0 , 792 were resected and analyzed. All of 21 SSA/Ps identified in 17 @entity0 were included in E-HPs, and the overall proportion of SSA/Ps in E-HPs was 2.7%. However, this proportion increased with the size of E-HPs ( <=5 mm: 0.7%; 6-9 mm: 29.0%; >= 10 mm: 70%) and was higher in the proximal colon than in the distal colorectum (10.9% vs. 0.9%). In addition, no SSA/P was found in the rectum, and no SSA/P had cytological @entity6 . CONCLUSIONS: The overall proportion of SSA/Ps in E-HPs was 2.7%, although this proportion was higher in the proximal colon and increased with the size of E-HPs. SSA/Ps were common in routine colonoscopy, with a prevalence of at least 5.0%. STUDY REGISTRATION: UMIN000010832.

title: Prospective evaluation of the proportion of sessile serrated @entity3 / @entity5 in endoscopically diagnosed XXXX with @entity7 features.

answer: @entity5


abstract: BACKGROUND: Multiple prior studies have suggested an association between survival and beta-blocker administration in @entity0 with severe @entity2 ( @entity2 ). However, it is unknown whether this benefit of beta-blockers is dependent on heart rate control. The aim of this study was to assess whether rate control affects survival in @entity0 receiving @entity4 with severe @entity2 . Our hypothesis was that improved survival from beta-blockade would be associated with a reduction in heart rate. METHODS: We performed a 7-y retrospective analysis of all blunt @entity2 @entity0 at a level-1 @entity1 center. @entity0 aged >16  y with head abbreviated @entity1 or 5, admitted to the intensive care unit (ICU) from the operating room or emergency room (ER), were included. @entity0 were stratified into two groups: @entity4 and no beta-blockers. Using propensity score matching, we matched the @entity0 in two groups in a 1:1 ratio controlling for age, gender, race, admission vital signs, @entity3 scale, injury severity score, mean heart rate monitored during ICU admission, and standard deviation of heart rate during the ICU admission. Our primary outcome measure was mortality. RESULTS: A total of 914 @entity0 met our inclusion criteria, of whom 189 received beta-blockers. A propensity-matched cohort of 356 @entity0 (178: @entity4 and 178: no beta-blockers) was created. @entity0 receiving @entity4 had higher survival than those @entity0 who did not receive beta-blockers (78% versus 68%; P  =  0.04); however, there was no difference in the mean heart rate (89.9      13.9 versus 89.9      15; P  =  0.99). Nor was there a difference in the mean of standard deviation of the heart rates (14.7      6.3 versus 14.4      6.5; P  =  0.65) between the two groups. In Kaplan-Meier survival analysis, @entity0 who received @entity4 had a survival advantage (P  =  0.011) compared with @entity0 who did not receive any beta-blockers. CONCLUSIONS: Our study shows an association with improved survival in @entity0 with severe @entity2 receiving @entity4 , and this effect appears to be independent of any reduction in heart rate. We suggest that beta-blockers should be administered to all severe @entity2 @entity0 irregardless of any perceived beta-blockade effect on heart rate.

title: @entity4 improves survival in severe XXXX independent of heart rate control.

answer: @entity2


abstract: BACKGROUND: Multiple prior studies have suggested an association between survival and beta-blocker administration in @entity0 with severe @entity2 ( @entity2 ). However, it is unknown whether this benefit of beta-blockers is dependent on heart rate control. The aim of this study was to assess whether rate control affects survival in @entity0 receiving @entity4 with severe @entity2 . Our hypothesis was that improved survival from beta-blockade would be associated with a reduction in heart rate. METHODS: We performed a 7-y retrospective analysis of all blunt @entity2 @entity0 at a level-1 @entity1 center. @entity0 aged >16  y with head abbreviated @entity1 or 5, admitted to the intensive care unit (ICU) from the operating room or emergency room (ER), were included. @entity0 were stratified into two groups: @entity4 and no beta-blockers. Using propensity score matching, we matched the @entity0 in two groups in a 1:1 ratio controlling for age, gender, race, admission vital signs, @entity3 scale, injury severity score, mean heart rate monitored during ICU admission, and standard deviation of heart rate during the ICU admission. Our primary outcome measure was mortality. RESULTS: A total of 914 @entity0 met our inclusion criteria, of whom 189 received beta-blockers. A propensity-matched cohort of 356 @entity0 (178: @entity4 and 178: no beta-blockers) was created. @entity0 receiving @entity4 had higher survival than those @entity0 who did not receive beta-blockers (78% versus 68%; P  =  0.04); however, there was no difference in the mean heart rate (89.9      13.9 versus 89.9      15; P  =  0.99). Nor was there a difference in the mean of standard deviation of the heart rates (14.7      6.3 versus 14.4      6.5; P  =  0.65) between the two groups. In Kaplan-Meier survival analysis, @entity0 who received @entity4 had a survival advantage (P  =  0.011) compared with @entity0 who did not receive any beta-blockers. CONCLUSIONS: Our study shows an association with improved survival in @entity0 with severe @entity2 receiving @entity4 , and this effect appears to be independent of any reduction in heart rate. We suggest that beta-blockers should be administered to all severe @entity2 @entity0 irregardless of any perceived beta-blockade effect on heart rate.

title: XXXX improves survival in severe @entity2 independent of heart rate control.

answer: @entity4


abstract: PURPOSE:   For the new generation of mandibular reconstruction, @entity0 -specific mandible reconstruction plates (PSMPs) have been developed which are milled from @entity2 after preoperative computer planning using CAD/CAM procedures. Resection margins and plate position are determined by surgical guides. In addition, length and shape of the plate and the number and angulation of the screw holes can be planned. METHODS:   30 @entity0 received such @entity3 . Indication ranged from stabilization osteosynthesis, single alloplastic stand-alone reconstruction to microvascular reconstructions. Time for planning, fit of surgical guides and plates, pre-/postoperative occlusion, radiological position of the temporo mandibular joint and complications were recorded. RESULTS:   The median time for online planning was 35  min. The results concerning fit and handling of the @entity3 and the surgical guides were mainly very positive. In six cases, the plan had to be adapted to the intraoperative clinical needs. The postoperative position of the condyles in the temporo mandibular fossae was regular in 28 cases. The evaluation of the occlusion was not representative due to not clearly identifiable occlusion in 2/3 of the cases. Nevertheless, complications like postoperative extraoral plate exposure, infection, graft and flap @entity1 or difficulties to position the guides or the plate during surgery occurred. CONCLUSIONS:   Mandibular reconstruction with @entity3 offers a broad range of opportunities and benefits compared with standard procedures and can be recommended for all kind of mandibular reconstructions. It is not yet foreseeable whether @entity3 will in future become routine clinical practice for mandibular reconstruction or will be confined to selected isolated cases.

title: Multicenter study on the use of XXXX -specific CAD/CAM reconstruction plates for mandibular reconstruction.

answer: @entity0


abstract: INTRODUCTION: We investigate the cytocidal effect of water on @entity2 cells. Intraperitoneal lavage with sterile water is sometimes used during radical cystectomy to lyse @entity1 cells that might have escaped the surgical specimen. The efficacy of this approach at the cellular level is unknown. METHODS: Three @entity2 cell lines of varying grade, RT4, TCCSUP and T24 were exposed to sterile water, and morphological changes were closely observed under microscopy. Changes of cell membrane integrity, cell viability, and cell number of re-incubated cells after water exposure were measured to determine water induced @entity4 . RESULTS: The low-grade RT4 cells started swelling immediately upon exposure to water followed by @entity3 within 3 minutes. The higher grade @entity0 and @entity0 cells demonstrated limited @entity4 swelling with significantly less cell @entity3 after 10 minutes. The damage to cell membrane of RT4 cells was evident at 1 minute; only 10.0% of cells were intact at 10 minutes. On the other hand, 41.9% and 77.8% of @entity0 and @entity0 cells were intact at 10 minutes, respectively. Percentage of viable cells at 10 minutes was 2.1    2.3%, 2.3    0.4%, and 16.1    0.6% for RT4, TCCSUP, and T24, respectively. CONCLUSIONS: Cytocidal effect of @entity4 can be achieved, to varying degrees, by exposing @entity2 cells to water for at least 10 minutes. This in vitro study may have bearing on the effects seen with intraperitoneal lavage using sterile water during radical cystectomy.

title: In-vitro cytocidal effect of water on XXXX cells: The potential role for intraperitoneal lavage during radical cystectomy.

answer: @entity2


abstract: BACKGROUND: @entity0 is the most frequently diagnosed @entity2 and the leading cause of @entity2 -related @entity3 among @entity1 worldwide. Herein, we examine global trends in female @entity0 rates using the most up-to-date data available. METHODS: @entity0 incidence and mortality estimates were obtained from GLOBOCAN 2012 (globocan.iarc.fr). We analyzed trends from 1993 onward using incidence data from 39 countries from the International Agency for Research on @entity2 and mortality data from 57 countries from the World Health Organization. RESULTS: Of 32 countries with incidence and mortality data, rates in the recent period diverged-with incidence increasing and mortality decreasing-in nine countries mainly in Northern/Western Europe. Both incidence and mortality decreased in France, Israel, Italy, Norway, and Spain. In contrast, incidence and @entity3 rates both increased in Colombia, Ecuador, and Japan. @entity3 rates also increased in Brazil, Egypt, Guatemala, Kuwait, Mauritius, Mexico, and Moldova. CONCLUSIONS: @entity0 mortality rates are decreasing in most high-income countries, despite increasing or stable incidence rates. In contrast and of concern are the increasing incidence and mortality rates in a number of countries, particularly those undergoing rapid changes in @entity1 development. Wide variations in @entity0 rates and trends reflect differences in patterns of risk factors and access to and availability of early detection and timely treatment. IMPACT: Increased awareness about @entity0 and the benefits of early detection and improved access to treatment must be prioritized to successfully implement @entity0 control programs, particularly in transitioning countries. @entity2 Epidemiol Biomarkers Prev; 24(10); 1-12.   2015 AACR.

title: International Variation in Female Breast XXXX Incidence and Mortality Rates.

answer: @entity2


abstract: OBJECTIVE: To show that @entity2 ( @entity2 ) that is generally believed to be a variant of @entity3 ( @entity3 ) and an analogue of chronic @entity7 is an initial stage and the background of all further forms of @entity3 . SUBJECTS AND METHODS: Sixty cardiac biopsies obtained from @entity0 during aortocoronary bypass surgery for @entity3 and myocardia from 55 @entity1 in which the investigators simulated @entity8 over time, as well as acute, transient, and recurrent @entity4 after vasopressin administration were examined. A number of adequate histological, histochemical, and immunohistological procedures, electron microscopic and electron histochemical studies, and morphometry were employed. The investigators made biochemical monitoring of blood cholesterol and triglyceride levels and ECG monitoring in the animals had received intravenous vasopressin. RESULTS: The authors have indicated that @entity3 begins with endothelial changes in the trophic component of the microhemocirculatory bed, which gives rise to its impaired blood flow and to @entity6 at the level of the myocardial structural and functional unit--fascicules. Over time, the disease develops a set of processes that cause damage to microvessels, cardiomyocytes, stroma, lymph capillaries, and nerve endings and changes in secretion. Compensatory and adaptive responses that long mask the symptoms of damage to the vascular bed and myocardial tissue take place simultaneously. The occurring lesions result in irregular diffuse cardiosclerosis, micro- and lymphocirculatory, innervation, and conduction disturbances, and irregular cardiomyocyte damage. The authors consider this set of myocardial changes to be an initial phase of @entity2 that shows no clinical manifestation at all. As @entity5 progresses, the already damaged myocardium is superimposed by the morphological changes caused by higher @entity6 at the whole organ level. Depending upon a combination of these changes, one or another form of @entity3 and progression of chronic @entity3 may prevail at a later time. CONCLUSION: @entity2 is a broader concept than chronic @entity7 and it is a basis for the pathogenesis and morphogenesis of @entity3 .

title: [Functional morphology of XXXX ].

answer: @entity2


abstract: OBJECTIVES: The transient breath holding sign (TBHS) is a clinical sign often associated with magnetic resonance imaging (MRI) spine traumatic lesions. The aims of this study were to prospectively evaluate the TBHS in the detection of thoracolumbar lesions in a large cohort of @entity0 and to establish a comprehensive strategy on the use of MRI in spine traumas in @entity0 . STUDY DESIGN: All conscious 5- to 16-year-old @entity0 admitted for a spine @entity2 in our institution were prospectively included in the study. All @entity0 were asked for the TBHS and underwent a full spine MRI. Sensitivity and specificity of the TBHS were derived from the confusion matrix. All @entity1 were analyzed and classified. RESULTS: One hundred ninety-eight @entity0 were included. The sensitivity of the TBHS was 92%, the specificity was 83%, the positive predictive value was 83%, and the negative predictive value was 91%. The x-rays missed 67% of the vertebrae injured in the MRI. The @entity1 consisted in an @entity2 , in the sagittal plane only, in 90% of the cases. The vertebral canal and the spinal cord were never injured. CONCLUSIONS: This study confirms that the TBHS is a relevant clinical tool that should be added in the routine questionnaire after any @entity2 at admission. Magnetic resonance imaging should be restricted to @entity0 with a TBHS positive at admission. A single T2 Short T1 Inversion Recovery (STIR) sagittal sequence seems sufficient to make the diagnosis and could replace the use of standard x-rays in pediatric spine traumas.

title: A New Paradigm for the Management of Thoracolumbar Pediatric Spine XXXX .

answer: @entity2


abstract: A 1.5-year-old, intact female khaki Campbell @entity7 ( @entity7 domesticus) was evaluated for lethargy and a swollen left eye ( @entity5 ). Mucoid discharge, chemosis, and @entity6 with trace aqueous flare, indicating anterior @entity4 , in the anterior chamber were evident on ophthalmic examination. There was no @entity2 stain uptake by the @entity0 . Initial topical antibiotic therapy and systemic anti-inflammatory treatments were unsuccessful, and the lesion progressed to a diffuse, yellow-white plaque, which covered 90%-95% of the @entity0 4 days later. There was moderate @entity10 , mild blepharedema, and @entity9 . The mobility of the nictitating membrane was impaired because of the presence of the plaque over the @entity0 . Cytologic examination of a corneal scraping revealed @entity1 , and aerobic culture confirmed Aspergillus species. Treatment with topical @entity8 (1 drop @entity5 q4h-q6h) was initiated and was switched to oral @entity8 (20 mg/kg PO q12h) 6 days after initiating treatment. The ocular disease improved during the antifungal treatment period. Eighty-four days after initial presentation (9 days after discontinuation of treatment), there was no clinical evidence of @entity3 on ophthalmic examination.

title: XXXX in a Khaki Campbell @entity7 ( @entity7 domesticus).

answer: @entity3


abstract: A 1.5-year-old, intact female khaki Campbell @entity7 ( @entity7 domesticus) was evaluated for lethargy and a swollen left eye ( @entity5 ). Mucoid discharge, chemosis, and @entity6 with trace aqueous flare, indicating anterior @entity4 , in the anterior chamber were evident on ophthalmic examination. There was no @entity2 stain uptake by the @entity0 . Initial topical antibiotic therapy and systemic anti-inflammatory treatments were unsuccessful, and the lesion progressed to a diffuse, yellow-white plaque, which covered 90%-95% of the @entity0 4 days later. There was moderate @entity10 , mild blepharedema, and @entity9 . The mobility of the nictitating membrane was impaired because of the presence of the plaque over the @entity0 . Cytologic examination of a corneal scraping revealed @entity1 , and aerobic culture confirmed Aspergillus species. Treatment with topical @entity8 (1 drop @entity5 q4h-q6h) was initiated and was switched to oral @entity8 (20 mg/kg PO q12h) 6 days after initiating treatment. The ocular disease improved during the antifungal treatment period. Eighty-four days after initial presentation (9 days after discontinuation of treatment), there was no clinical evidence of @entity3 on ophthalmic examination.

title: @entity3 in a Khaki Campbell XXXX ( @entity7 domesticus).

answer: @entity7


abstract: A 1.5-year-old, intact female khaki Campbell @entity7 ( @entity7 domesticus) was evaluated for lethargy and a swollen left eye ( @entity5 ). Mucoid discharge, chemosis, and @entity6 with trace aqueous flare, indicating anterior @entity4 , in the anterior chamber were evident on ophthalmic examination. There was no @entity2 stain uptake by the @entity0 . Initial topical antibiotic therapy and systemic anti-inflammatory treatments were unsuccessful, and the lesion progressed to a diffuse, yellow-white plaque, which covered 90%-95% of the @entity0 4 days later. There was moderate @entity10 , mild blepharedema, and @entity9 . The mobility of the nictitating membrane was impaired because of the presence of the plaque over the @entity0 . Cytologic examination of a corneal scraping revealed @entity1 , and aerobic culture confirmed Aspergillus species. Treatment with topical @entity8 (1 drop @entity5 q4h-q6h) was initiated and was switched to oral @entity8 (20 mg/kg PO q12h) 6 days after initiating treatment. The ocular disease improved during the antifungal treatment period. Eighty-four days after initial presentation (9 days after discontinuation of treatment), there was no clinical evidence of @entity3 on ophthalmic examination.

title: @entity3 in a Khaki Campbell @entity7 ( XXXX domesticus).

answer: @entity7