abstract: BACKGROUND: Relative to other aspects of Down syndrome, remarkably little is known about the @entity3 problems experienced by youth and young adults with this syndrome and if these problems differ from others with @entity7 . Yet adolescence and young adulthood are particularly vulnerable time periods, as they involve multiple life transitions in educational, medical, and other service systems. METHODS: This study compared the @entity3 diagnoses of 49 adolescent and young adult @entity0 with Down syndrome to 70 @entity0 with other @entity7 ( @entity7 ). The groups were similar in age, gender, and level of @entity2 . The 119 @entity0 , aged 13 to 29  years (M   =   21) were evaluated in one of two specialized @entity3 clinics. RESULTS: In contrast to previous literature, those with Down syndrome versus other @entity7 had significantly higher rates of @entity6 NOS or @entity5 with @entity6 features (43% versus 13%). Unlike the ID group, @entity6 was predominantly seen in females with Down syndrome. Marked motoric slowing in performing routine daily activities or in expressive language was manifested in 17% of @entity0 with Down syndrome. No group differences were found in @entity4 or @entity5 , and the ID group had significantly higher rates of bipolar and @entity1 . CONCLUSIONS: These preliminary observations warrant further studies on genetic, neurological, and psychosocial factors that place some young @entity0 with Down syndrome or other @entity7 at high risk for severe @entity3 .

title: XXXX in adolescents and young adults with Down syndrome and other @entity7 .

answer: @entity3


abstract: BACKGROUND: Relative to other aspects of Down syndrome, remarkably little is known about the @entity3 problems experienced by youth and young adults with this syndrome and if these problems differ from others with @entity7 . Yet adolescence and young adulthood are particularly vulnerable time periods, as they involve multiple life transitions in educational, medical, and other service systems. METHODS: This study compared the @entity3 diagnoses of 49 adolescent and young adult @entity0 with Down syndrome to 70 @entity0 with other @entity7 ( @entity7 ). The groups were similar in age, gender, and level of @entity2 . The 119 @entity0 , aged 13 to 29  years (M   =   21) were evaluated in one of two specialized @entity3 clinics. RESULTS: In contrast to previous literature, those with Down syndrome versus other @entity7 had significantly higher rates of @entity6 NOS or @entity5 with @entity6 features (43% versus 13%). Unlike the ID group, @entity6 was predominantly seen in females with Down syndrome. Marked motoric slowing in performing routine daily activities or in expressive language was manifested in 17% of @entity0 with Down syndrome. No group differences were found in @entity4 or @entity5 , and the ID group had significantly higher rates of bipolar and @entity1 . CONCLUSIONS: These preliminary observations warrant further studies on genetic, neurological, and psychosocial factors that place some young @entity0 with Down syndrome or other @entity7 at high risk for severe @entity3 .

title: @entity3 in adolescents and young adults with Down syndrome and other XXXX .

answer: @entity7


abstract: INTRODUCTION: In Africa and Asia hair dye is applied together with henna to decorate the hands and feet. @entity5 ( @entity6 ), a highly toxic constituent of hair dye can lead to @entity2 ( @entity2 ). METHODS: A cohort study was conducted during the period from April 2012 to March 2013 in Khartoum Teaching Hospital, Sudan. It targeted adults presenting acutely with an evident history and clinical features of hair dye @entity4 , together with @entity2 as per the RIFLE criteria. Analysis of data was done using SPSS. RESULTS: 30 adults were included, their mean age was 25.6    4.2 years, 93.3% were females. Exposure to @entity6 was suicidal in 86.7%. The mean duration to onset of renal symptoms was 34.8    7.6 hours, maximum median serum @entity3 was 8.6    2.3 mg/dl, 86.7% had @entity1 as per the RIFLE classification and required dialysis. @entity1 was seen after a mean duration of 9.8    2.2 days. One @entity0 died, 3.3%; all others, 96.7%, recovered normal kidney function. The amount of ingested @entity6 correlated significantly to the severity of symptoms, number of dialysis sessions required and time for renal recovery with P values < 0.05. CONCLUSION: Hair dye @entity4 was associated with prolonged hospital stay, requirement of dialysis and increased morbidity. The severity of symptoms directly correlates to the dose of @entity6 ingested, with the @entity1 being reversible in almost all survivors.

title: Clinical presentation, treatment and outcome of XXXX induced @entity2 following hair dye @entity4 : a cohort study.

answer: @entity5


abstract: INTRODUCTION: In Africa and Asia hair dye is applied together with henna to decorate the hands and feet. @entity5 ( @entity6 ), a highly toxic constituent of hair dye can lead to @entity2 ( @entity2 ). METHODS: A cohort study was conducted during the period from April 2012 to March 2013 in Khartoum Teaching Hospital, Sudan. It targeted adults presenting acutely with an evident history and clinical features of hair dye @entity4 , together with @entity2 as per the RIFLE criteria. Analysis of data was done using SPSS. RESULTS: 30 adults were included, their mean age was 25.6    4.2 years, 93.3% were females. Exposure to @entity6 was suicidal in 86.7%. The mean duration to onset of renal symptoms was 34.8    7.6 hours, maximum median serum @entity3 was 8.6    2.3 mg/dl, 86.7% had @entity1 as per the RIFLE classification and required dialysis. @entity1 was seen after a mean duration of 9.8    2.2 days. One @entity0 died, 3.3%; all others, 96.7%, recovered normal kidney function. The amount of ingested @entity6 correlated significantly to the severity of symptoms, number of dialysis sessions required and time for renal recovery with P values < 0.05. CONCLUSION: Hair dye @entity4 was associated with prolonged hospital stay, requirement of dialysis and increased morbidity. The severity of symptoms directly correlates to the dose of @entity6 ingested, with the @entity1 being reversible in almost all survivors.

title: Clinical presentation, treatment and outcome of @entity5 induced @entity2 following hair dye XXXX : a cohort study.

answer: @entity4


abstract: INTRODUCTION: In Africa and Asia hair dye is applied together with henna to decorate the hands and feet. @entity5 ( @entity6 ), a highly toxic constituent of hair dye can lead to @entity2 ( @entity2 ). METHODS: A cohort study was conducted during the period from April 2012 to March 2013 in Khartoum Teaching Hospital, Sudan. It targeted adults presenting acutely with an evident history and clinical features of hair dye @entity4 , together with @entity2 as per the RIFLE criteria. Analysis of data was done using SPSS. RESULTS: 30 adults were included, their mean age was 25.6    4.2 years, 93.3% were females. Exposure to @entity6 was suicidal in 86.7%. The mean duration to onset of renal symptoms was 34.8    7.6 hours, maximum median serum @entity3 was 8.6    2.3 mg/dl, 86.7% had @entity1 as per the RIFLE classification and required dialysis. @entity1 was seen after a mean duration of 9.8    2.2 days. One @entity0 died, 3.3%; all others, 96.7%, recovered normal kidney function. The amount of ingested @entity6 correlated significantly to the severity of symptoms, number of dialysis sessions required and time for renal recovery with P values < 0.05. CONCLUSION: Hair dye @entity4 was associated with prolonged hospital stay, requirement of dialysis and increased morbidity. The severity of symptoms directly correlates to the dose of @entity6 ingested, with the @entity1 being reversible in almost all survivors.

title: Clinical presentation, treatment and outcome of @entity5 induced XXXX following hair dye @entity4 : a cohort study.

answer: @entity2


abstract: BACKGROUND: The incidence of difficult intubation in @entity0 undergoing general anaesthesia is estimated to be approximately 1-18% whereas that of failure to intubate is 0.05-0.35%.1,2,3 Various methods have been used for prediction of difficult laryngoscopy. Although, upper lip bite has been shown to be a promising test in its introductory article, repeated validation in various populations is required for any test to be accepted as a routine test. We have compared upper lip bite test (ULBT), modified Mallampati test (MMC) and @entity1 ( @entity1 ) individually and in various combinations to verify which of these predictor tests are significantly associated with difficult glottic exposure. METHODS: After obtaining institutional ethics committee approval, 402 ASA I and II adult @entity0 undergoing elective surgical procedures requiring endotracheal intubation were included. All the three test were performed in all the @entity0 preoperatively and their glottic exposure was recorded by Cormack-Lehane classification during intubation. Sensitivity, specificity, positive predictive value and negative predictive value were used for comparison. RESULTS: In our study, the incidence of difficult laryngoscopy was 11.4% and failure to intubate 0.49%. None of the three are a suitable predictive test when used alone. Combination of tests added incremental diagnostic value. CONCLUSION: We conclude that all three screening tests for difficult intubation have only poor to moderate discriminative power when used alone. Combinations of individual tests add some incremental diagnostic value.

title: Prediction of ease of laryngoscopy and intubation-role of upper lip bite test, modified mallampati classification, and XXXX in various combination.

answer: @entity1


abstract: UNASSIGNED: Reinforcement occurs when behavioral isolation is strengthened between species due to selection against hybridization in sympatry. Mate preferences and their target traits may change in sympatry as a consequence of reinforcement. This can potentially generate further behavioral isolation within species if sympatric populations evolve extreme preferences or traits that cause them to reject individuals from foreign populations as mates or be rejected as mates. This process is known as cascade reinforcement. We measured behavioral isolation between sympatric and allopatric populations of Lucania @entity0 to determine whether isolation evolves due to reinforcement between species and whether reinforcement affects preferences within species, consistent with the cascade reinforcement hypothesis. We measured mate preferences in both sexes between species (Lucania parva vs. Lucania goodei) and within species (among populations of @entity1 ). Between species, both male and female preferences for conspecifics were highest in sympatric populations. Within species, @entity1 females from sympatric populations preferred their own native males over foreign males. Allopatric @entity1 females and all @entity1 males showed no preferences within species. Within species, behavioral isolation showed no association with ecological variables, such as salinity. Thus, reinforcement is a primary factor generating behavioral isolation in Lucania @entity0 , creating strong preferences in both sexes among species and leading to cascade reinforcement of female mate preference within species.

title: Behavioral Isolation due to Cascade Reinforcement in Lucania XXXX .

answer: @entity0


abstract: Importance: @entity3 of the jaws is rare and clinically distinct from @entity3 of the long bones of the body with different treatment and outcomes. The literature on these @entity1 is limited to case reports and small case series mostly from single institutions. We used data from the population-based national Surveillance, Epidemiology and End Results (SEER) @entity1 registry to determine the epidemiology and prognostic factors associated with @entity3 of the jaws. Objective: To investigate the epidemiologic characteristics and prognostic factors for survival in @entity0 diagnosed with @entity3 of the jaws. Design, Setting, and @entity0 : A retrospective, population-based cohort study of 541 @entity0 in the SEER @entity1 registry diagnosed with @entity3 of the jaws from 1973 through 2011 were reviewed. Exposures: @entity0 had been treated with surgery, radiation, both, or neither. Main Outcomes and Measures: Overall and @entity2 . Results: A total of 541 @entity0 diagnosed with @entity3 of the jaws were identified (49.9% male and 50.1% female, with a mean age of 41.3 years). Kaplan-Meier analysis demonstrated an @entity4 ( @entity4 ) and @entity2 ( @entity2 ) of 53% and 62%, respectively, at 5 years and 35% and 54%, respectively, at 10 years. Multivariate Cox regression analysis revealed that independent predictors of @entity4 and @entity2 included age at diagnosis (hazard ratio [HR], 1.03; 95% CI, 1.02-1.04 [P   <   .001] for @entity4 ; and HR, 1.03; 95% CI, 1.02-1.05 [P   <   .001] for @entity2 ); stage at presentation (HR, 1.37; 95% CI, 1.10-1.71 [P   =   .006] for @entity4 ; and HR, 1.34; 95% CI, 1.01-1.76 [P   =   .04] for @entity2 ); and surgical resection (HR, 0.31; 95% CI, 0.16-0.60 [P   <   .001] for @entity4 ; and HR, 0.22; 95% CI, 0.09-0.56 [P   =   .001] for @entity2 ). @entity1 size was not significant for @entity4 (HR, 1.00; 95% CI, 1.00-1.01 [P   =   .11] but significant for @entity2 (HR, 1.01; 95% CI, 1.00-1.01 [P   =   .003]). Conclusions and Relevance: To our knowledge, this is the largest study to date investigating prognostic factors for survival in @entity0 diagnosed with @entity3 of the jaws. Determinants of survival include age at diagnosis, stage at presentation, @entity1 size, and surgical therapy. Radiation therapy was not associated with improved survival, reflecting the controversy surrounding its use in in clinical literature.

title: Characteristics and Prognostic Factors of XXXX of the Jaws: A Retrospective Cohort Study.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity3 . Although, the molecular mechanism is not completely understood, @entity4 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity6 (eNOS @entity7 ) gene polymorphism in @entity1 and/or non- @entity1 @entity5 @entity0 (2) to investigate the possible relationship between the eNOS @entity7 polymorphism and the risk of @entity1 among @entity5 @entity0 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity2 @entity0 and Methods: Gene profiles of 75 @entity5 @entity0 (21 @entity1 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity0 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity7 single-nucleotide polymorphism (SNP) was determined in @entity5 @entity0 when compared with normotensive non- @entity5 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity1 @entity5 @entity0 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5 @entity0 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity7 polymorphism and @entity1 among @entity5 @entity0 in the Turkish population. The T allele frequency of eNOS @entity7 SNP was different in @entity1 @entity5 @entity0 , and the difference was statistically significant when compared with the normotensive @entity5 @entity0 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of @entity6 XXXX gene polymorphism in @entity4 cases with @entity1 .

answer: @entity7


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity3 . Although, the molecular mechanism is not completely understood, @entity4 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity6 (eNOS @entity7 ) gene polymorphism in @entity1 and/or non- @entity1 @entity5 @entity0 (2) to investigate the possible relationship between the eNOS @entity7 polymorphism and the risk of @entity1 among @entity5 @entity0 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity2 @entity0 and Methods: Gene profiles of 75 @entity5 @entity0 (21 @entity1 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity0 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity7 single-nucleotide polymorphism (SNP) was determined in @entity5 @entity0 when compared with normotensive non- @entity5 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity1 @entity5 @entity0 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5 @entity0 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity7 polymorphism and @entity1 among @entity5 @entity0 in the Turkish population. The T allele frequency of eNOS @entity7 SNP was different in @entity1 @entity5 @entity0 , and the difference was statistically significant when compared with the normotensive @entity5 @entity0 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of @entity6 @entity7 gene polymorphism in XXXX cases with @entity1 .

answer: @entity4


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity3 . Although, the molecular mechanism is not completely understood, @entity4 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity6 (eNOS @entity7 ) gene polymorphism in @entity1 and/or non- @entity1 @entity5 @entity0 (2) to investigate the possible relationship between the eNOS @entity7 polymorphism and the risk of @entity1 among @entity5 @entity0 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity2 @entity0 and Methods: Gene profiles of 75 @entity5 @entity0 (21 @entity1 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity0 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity7 single-nucleotide polymorphism (SNP) was determined in @entity5 @entity0 when compared with normotensive non- @entity5 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity1 @entity5 @entity0 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5 @entity0 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity7 polymorphism and @entity1 among @entity5 @entity0 in the Turkish population. The T allele frequency of eNOS @entity7 SNP was different in @entity1 @entity5 @entity0 , and the difference was statistically significant when compared with the normotensive @entity5 @entity0 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of @entity6 @entity7 gene polymorphism in @entity4 cases with XXXX .

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity3 . Although, the molecular mechanism is not completely understood, @entity4 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity6 (eNOS @entity7 ) gene polymorphism in @entity1 and/or non- @entity1 @entity5 @entity0 (2) to investigate the possible relationship between the eNOS @entity7 polymorphism and the risk of @entity1 among @entity5 @entity0 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity2 @entity0 and Methods: Gene profiles of 75 @entity5 @entity0 (21 @entity1 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity0 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity7 single-nucleotide polymorphism (SNP) was determined in @entity5 @entity0 when compared with normotensive non- @entity5 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity1 @entity5 @entity0 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5 @entity0 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity7 polymorphism and @entity1 among @entity5 @entity0 in the Turkish population. The T allele frequency of eNOS @entity7 SNP was different in @entity1 @entity5 @entity0 , and the difference was statistically significant when compared with the normotensive @entity5 @entity0 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of XXXX @entity7 gene polymorphism in @entity4 cases with @entity1 .

answer: @entity6


abstract: UNASSIGNED: Vascular characteristics, hypoxia and tumor budding are features that have been implied in the biology and prognosis of @entity0 . Internal relationships and the inter- and intra-tumoral variation of these tumor properties remain to be determined. In the current study we have characterized blood vessel status in different areas of @entity0 and in the peritumoral fibroblastic stroma. Analyses of these characteristics have been supplemented by characterization of budding and hypoxia. Analyses revealed significantly lower values of @entity2 ( @entity2 ) and @entity2 ( @entity2 ) at the invasive front and surrounding stroma as compared to the tumor center. Also, the number of vessels (VN) in the peritumoral stroma was higher than in the center. Thus, tumor center displays larger and fewer vessels as compared to the tumor periphery. @entity1 expression was correlated directly with VN (r=0.351, p=0.028) and inversely with @entity2 and @entity2 (r=-0.432, p=0.006 and r=-0.484, p=0.002) at the invasive front. Moreover, @entity1 expression, @entity2 at the invasive front, and VN in the surrounding peritumoral stroma, were associated with budding score (r=0.574, p<0.000, r=-0.340, p=0,034 and r=-0.389, p=0.025 respectively). Furthermore, @entity1 , budding score, vessel number in peritumoral stroma, and vessel size in the invasive front, were significantly different in tumors with or without lymph node metastasis. This study reports previously unrecognized relationships between localization-specific vascular characteristics, hypoxia and tumor budding. The findings suggest potential functional relationships, which should be further explored, and also highlight the inter-tumoral variations in vasculature, which is highly relevant for ongoing efforts to identify vessel-based biomarkers.

title: Inter- and intra-tumoral relationships between vasculature characteristics, XXXX and budding in @entity0 .

answer: @entity1


abstract: UNASSIGNED: Vascular characteristics, hypoxia and tumor budding are features that have been implied in the biology and prognosis of @entity0 . Internal relationships and the inter- and intra-tumoral variation of these tumor properties remain to be determined. In the current study we have characterized blood vessel status in different areas of @entity0 and in the peritumoral fibroblastic stroma. Analyses of these characteristics have been supplemented by characterization of budding and hypoxia. Analyses revealed significantly lower values of @entity2 ( @entity2 ) and @entity2 ( @entity2 ) at the invasive front and surrounding stroma as compared to the tumor center. Also, the number of vessels (VN) in the peritumoral stroma was higher than in the center. Thus, tumor center displays larger and fewer vessels as compared to the tumor periphery. @entity1 expression was correlated directly with VN (r=0.351, p=0.028) and inversely with @entity2 and @entity2 (r=-0.432, p=0.006 and r=-0.484, p=0.002) at the invasive front. Moreover, @entity1 expression, @entity2 at the invasive front, and VN in the surrounding peritumoral stroma, were associated with budding score (r=0.574, p<0.000, r=-0.340, p=0,034 and r=-0.389, p=0.025 respectively). Furthermore, @entity1 , budding score, vessel number in peritumoral stroma, and vessel size in the invasive front, were significantly different in tumors with or without lymph node metastasis. This study reports previously unrecognized relationships between localization-specific vascular characteristics, hypoxia and tumor budding. The findings suggest potential functional relationships, which should be further explored, and also highlight the inter-tumoral variations in vasculature, which is highly relevant for ongoing efforts to identify vessel-based biomarkers.

title: Inter- and intra-tumoral relationships between vasculature characteristics, @entity1 and budding in XXXX .

answer: @entity0


abstract: BACKGROUND: @entity3 and @entity3 are 2 different presentations of the most common @entity5 in western countries ( @entity3 ). In this disease, @entity1 is usually silent, and is rarely reported in the literature. This study provides a clinicopathological analysis of all-cause @entity1 in @entity3 @entity0 . METHODS: Fifteen @entity3 @entity0 with kidney biopsy were identified retrospectively. Demographic, clinical, pathological and laboratory data were assessed at biopsy, and during follow-up. RESULTS: At biopsy 11 @entity0 presented @entity1 , 7 @entity0 @entity6 , 6 @entity0 dysproteinemia, and 3 @entity0 @entity9 . Kidney pathology revealed @entity3 -specific monoclonal infiltrate in 10 biopsies, @entity1 in 9 biopsies (5 membranoproliferative @entity2 , 2 minimal change disease, 1 @entity2 with organized microtubular monoclonal immunoglobulin deposits, 1 @entity8 ). Five @entity0 presented @entity7 attributed to @entity3 . After treatment of the @entity4 , improvement of renal function was observed in 7/11 @entity0 , and remission of @entity6 in 5/7 @entity0 . During follow-up, aggravation of the @entity1 systematically occurred in the absence of favorable response to hematological treatment. CONCLUSIONS: A broad spectrum of @entity1 is associated with @entity3 . In this setting, kidney biopsy can provide important information for diagnosis and therapeutic guidance.

title: The Spectrum of Kidney Pathology in @entity3 / XXXX : A 25-Year Multicenter Experience.

answer: @entity3


abstract: BACKGROUND: @entity3 and @entity3 are 2 different presentations of the most common @entity5 in western countries ( @entity3 ). In this disease, @entity1 is usually silent, and is rarely reported in the literature. This study provides a clinicopathological analysis of all-cause @entity1 in @entity3 @entity0 . METHODS: Fifteen @entity3 @entity0 with kidney biopsy were identified retrospectively. Demographic, clinical, pathological and laboratory data were assessed at biopsy, and during follow-up. RESULTS: At biopsy 11 @entity0 presented @entity1 , 7 @entity0 @entity6 , 6 @entity0 dysproteinemia, and 3 @entity0 @entity9 . Kidney pathology revealed @entity3 -specific monoclonal infiltrate in 10 biopsies, @entity1 in 9 biopsies (5 membranoproliferative @entity2 , 2 minimal change disease, 1 @entity2 with organized microtubular monoclonal immunoglobulin deposits, 1 @entity8 ). Five @entity0 presented @entity7 attributed to @entity3 . After treatment of the @entity4 , improvement of renal function was observed in 7/11 @entity0 , and remission of @entity6 in 5/7 @entity0 . During follow-up, aggravation of the @entity1 systematically occurred in the absence of favorable response to hematological treatment. CONCLUSIONS: A broad spectrum of @entity1 is associated with @entity3 . In this setting, kidney biopsy can provide important information for diagnosis and therapeutic guidance.

title: The Spectrum of Kidney Pathology in XXXX / @entity3 : A 25-Year Multicenter Experience.

answer: @entity3


abstract: UNASSIGNED: Background: Over the course of @entity1 towards the end-of-life, @entity0 may experience symptoms that lead to distressing @entity3 ( @entity3 ) for the @entity0 and caregivers. Methods: We analysed the records of 133 @entity0 cared for by our paediatric palliative care team (PPCT) from 01/98-12/09. A @entity3 was defined as deterioration of a condition caused by a symptom, which was life-threatening or acutely scaring the @entity0 (pt) or caregivers. Results: The majority of pts who died sustained no @entity3 . In 38 (28.6%) pts 45 @entity3 occurred. These accumulated towards the end-of-life (62.2% within the last week). About two-thirds were anticipated. There was no clustering of @entity3 during the night/weekend. Leading symptoms were neurological. In 4 @entity3 a pre-hospital emergency physician was alerted. 5 pts were readmitted to hospital. Most @entity3 (88.9%) could be controlled in the home setting. Discussion: Despite anticipation, a relevant number of pts developed @entity3 , which needed either additional medical intervention or other support by the PPCT. Considering the distressing and suffering character of @entity2 and dyspnoea, it is important to thoroughly address these conditions in palliative care. Conclusion: Advanced planning, close contact, good communication, detailed parental information, and a 24-h on-call service can reduce @entity3 in @entity0 with @entity1 . @entity3 are mainly manageable within the home setting. Treatment of @entity3 should focus on the @entity0 's symptoms and wishes, and the needs of the whole family.

title: Critical Situations in @entity0 , Adolescents and Young Adults with XXXX within the Home Setting.

answer: @entity1


abstract: UNASSIGNED: Background: Over the course of @entity1 towards the end-of-life, @entity0 may experience symptoms that lead to distressing @entity3 ( @entity3 ) for the @entity0 and caregivers. Methods: We analysed the records of 133 @entity0 cared for by our paediatric palliative care team (PPCT) from 01/98-12/09. A @entity3 was defined as deterioration of a condition caused by a symptom, which was life-threatening or acutely scaring the @entity0 (pt) or caregivers. Results: The majority of pts who died sustained no @entity3 . In 38 (28.6%) pts 45 @entity3 occurred. These accumulated towards the end-of-life (62.2% within the last week). About two-thirds were anticipated. There was no clustering of @entity3 during the night/weekend. Leading symptoms were neurological. In 4 @entity3 a pre-hospital emergency physician was alerted. 5 pts were readmitted to hospital. Most @entity3 (88.9%) could be controlled in the home setting. Discussion: Despite anticipation, a relevant number of pts developed @entity3 , which needed either additional medical intervention or other support by the PPCT. Considering the distressing and suffering character of @entity2 and dyspnoea, it is important to thoroughly address these conditions in palliative care. Conclusion: Advanced planning, close contact, good communication, detailed parental information, and a 24-h on-call service can reduce @entity3 in @entity0 with @entity1 . @entity3 are mainly manageable within the home setting. Treatment of @entity3 should focus on the @entity0 's symptoms and wishes, and the needs of the whole family.

title: Critical Situations in XXXX , Adolescents and Young Adults with @entity1 within the Home Setting.

answer: @entity0


abstract: @entity9 is a rare @entity6 in which @entity7 -containing glycolipids, glycoproteins and oligosaccharides accumulate in tissues, as a result of a deficiency of a-L-fucosidase. In this report we describe clinical, dysmorphological and radiological findings of a @entity0 with this disorder. @entity2 , @entity1 and mild coarsening of the face began at two years of age. Clinical signs typical for @entity9 evolved over time. Psychomotor deterioration progressed slowly. At age 12, he could not walk without help; he was admitted to the hospital with @entity3 , @entity4 and coarse facial features. A skeletal survey showed @entity10 . Cranial MRI demonstrated high intensities on the periventricular white matter and low intensities on the basal ganglia on T2- weighted images. Despite the absence of @entity8 on the skin, @entity5 was suspected. The diagnosis was established on the basis of severely decreased activity of a-L-fucosidase in the leukocytes. The natural history and specific dysmorphic and radiological findings should, even in the absence of @entity8 , assist in the differential diagnosis of this rare condition when @entity6 are suspected, particularly in populations in which consanguineous marriages are common.

title: A case of XXXX : diagnosed with dysmorphological and radiological findings.

answer: @entity9


abstract: BACKGROUND AND OBJECTIVES: Once classic treatments such as chemotherapy or radiation therapy have been exhausted, only few therapeutic options remain for extensive @entity10 or cutaneous @entity2 . In such cases, electrochemotherapy may be considered as alternative therapy. @entity1 AND METHODS: In this retrospective study, clinical features, treatment response, and adverse effects were evaluated in 56 @entity1 treated with electrochemotherapy at six German dermatology departments. RESULTS: The mean age of the @entity1 cohort (14 @entity1 , 42 @entity1 ) was 69.3 years. Included were 20 @entity1 with skin metastasis of advanced @entity6 , 13 @entity1 with @entity0 @entity2 , 15 @entity1 with primary @entity9 or cutaneous @entity2 of other @entity4 types, and 8 @entity1 with @entity8 or @entity5 . The overall response rate was 44.6% (10.7% complete response; 33.9% partial response). By contrast, 31 (55.4%) @entity1 did not respond (12.5% had stable disease; 42.9%, @entity3 progression). @entity1 with @entity6 and @entity8 or @entity5 responded significantly better than those with @entity4 . Roughly one quarter of @entity1 showed an improvement in @entity3 -related exudation, fetor, and @entity7 . CONCLUSION: Showing only few adverse effects, electrochemotherapy was effective in about one half of the @entity1 with advanced @entity3 . Treatment response appears to depend on the @entity3 entity.

title: Electrochemotherapy in advanced @entity10 and cutaneous XXXX - a retrospective multicenter analysis.

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: Once classic treatments such as chemotherapy or radiation therapy have been exhausted, only few therapeutic options remain for extensive @entity10 or cutaneous @entity2 . In such cases, electrochemotherapy may be considered as alternative therapy. @entity1 AND METHODS: In this retrospective study, clinical features, treatment response, and adverse effects were evaluated in 56 @entity1 treated with electrochemotherapy at six German dermatology departments. RESULTS: The mean age of the @entity1 cohort (14 @entity1 , 42 @entity1 ) was 69.3 years. Included were 20 @entity1 with skin metastasis of advanced @entity6 , 13 @entity1 with @entity0 @entity2 , 15 @entity1 with primary @entity9 or cutaneous @entity2 of other @entity4 types, and 8 @entity1 with @entity8 or @entity5 . The overall response rate was 44.6% (10.7% complete response; 33.9% partial response). By contrast, 31 (55.4%) @entity1 did not respond (12.5% had stable disease; 42.9%, @entity3 progression). @entity1 with @entity6 and @entity8 or @entity5 responded significantly better than those with @entity4 . Roughly one quarter of @entity1 showed an improvement in @entity3 -related exudation, fetor, and @entity7 . CONCLUSION: Showing only few adverse effects, electrochemotherapy was effective in about one half of the @entity1 with advanced @entity3 . Treatment response appears to depend on the @entity3 entity.

title: Electrochemotherapy in advanced XXXX and cutaneous @entity2 - a retrospective multicenter analysis.

answer: @entity10


abstract: OBJECTIVE: To assess genetic mutations and associated @entity2 in a series of @entity0 with 46,XY @entity3 ( @entity3 ). DESIGN: Single center retrospective study. SETTING: University pediatric hospital. @entity0 (S): Fourteen @entity0 with 46,XY @entity3 . INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotype-phenotype relationship. RESULT(S): The presenting symptom was @entity8 (6 @entity0 ), primary @entity6 (2 @entity0 ), discordance between 46,XY karyotype and female external genitalia (3 @entity0 ), discovery of M  llerian structures at surgery (2 @entity0 ), or diagnosed in the evaluation of a @entity1 (1 @entity0 ). M  llerian structures were shown by ultrasound evaluation in 7 of 13 @entity0 , genitography in 3 of 6 @entity0 and/or surgery in 8 of 10 @entity0 (3 not seen at imaging), or only by histologic examination (1 @entity0 ). Three @entity0 had @entity9 and/or @entity7 . A mutation was found in 7 @entity0 of whom 2 had family history of reproductive problems and 5 had associated @entity2 . The mutations were @entity11 / @entity11 (1 @entity0 ), SRY (2 @entity0 ), @entity10 (1 @entity0 ), or deletions of distal chromosome 9p (3 @entity0 ). Among the three other @entity0 with associated anomalies and no mutation, two had @entity5 and one had @entity4 . CONCLUSION(S): Mutations were observed in half of the @entity0 with 46,XY @entity3 with M  llerian structures. We also describe for the first time the association between @entity3 and @entity5 . M  llerian structures can be found in some cases only by histologic examination, which should be coupled to preventive gonadectomy because of the risk of @entity1 formation.

title: Genetic mutations and @entity2 in association with 46,XY XXXX .

answer: @entity3


abstract: OBJECTIVE: To assess genetic mutations and associated @entity2 in a series of @entity0 with 46,XY @entity3 ( @entity3 ). DESIGN: Single center retrospective study. SETTING: University pediatric hospital. @entity0 (S): Fourteen @entity0 with 46,XY @entity3 . INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Genotype-phenotype relationship. RESULT(S): The presenting symptom was @entity8 (6 @entity0 ), primary @entity6 (2 @entity0 ), discordance between 46,XY karyotype and female external genitalia (3 @entity0 ), discovery of M  llerian structures at surgery (2 @entity0 ), or diagnosed in the evaluation of a @entity1 (1 @entity0 ). M  llerian structures were shown by ultrasound evaluation in 7 of 13 @entity0 , genitography in 3 of 6 @entity0 and/or surgery in 8 of 10 @entity0 (3 not seen at imaging), or only by histologic examination (1 @entity0 ). Three @entity0 had @entity9 and/or @entity7 . A mutation was found in 7 @entity0 of whom 2 had family history of reproductive problems and 5 had associated @entity2 . The mutations were @entity11 / @entity11 (1 @entity0 ), SRY (2 @entity0 ), @entity10 (1 @entity0 ), or deletions of distal chromosome 9p (3 @entity0 ). Among the three other @entity0 with associated anomalies and no mutation, two had @entity5 and one had @entity4 . CONCLUSION(S): Mutations were observed in half of the @entity0 with 46,XY @entity3 with M  llerian structures. We also describe for the first time the association between @entity3 and @entity5 . M  llerian structures can be found in some cases only by histologic examination, which should be coupled to preventive gonadectomy because of the risk of @entity1 formation.

title: Genetic mutations and XXXX in association with 46,XY @entity3 .

answer: @entity2


abstract: BACKGROUND: The Ventricular Assist Device for the Treatment of Advanced @entity5 (ADVANCE) Bridge to Transplant (BTT) trial was a multicenter, prospective trial of the HeartWare Ventricular Assist Device (HVAD). The performance of the HVAD in various demographic sub-groups was evaluated. METHODS: Baseline characteristics, adverse events, and survival were compared for @entity0 vs @entity0 and whites vs non-whites in the combined ADVANCE BTT and continued access protocol trial. Of 332 @entity0 enrolled in these trials, 236 were @entity0 and 96 @entity0 , with 228 whites and 104 non-whites. RESULTS: At baseline, @entity0 had a smaller body surface area (1.8    0.2 vs 2.1    0.3 m(2), p < 0.0001), less @entity1 (50.0% vs 61.9%, p = 0.05), and less @entity3 (15.6% vs 45.3%, p < 0.0001). Differences in Kaplan-Meier survival were not significant at 180 days ( @entity0 , 91.8%; @entity0 , 91.7%) and 1 year ( @entity0 , 85.3%; @entity0 , 85.1%) despite adjustment for baseline differences. @entity0 had a lower incidence of early right @entity5 and @entity2 , and a shorter length of stay. In the analysis by race, non-whites were younger than whites and had less @entity5 , more @entity1 , and lower @entity7 levels at baseline. Non-whites had lower rates of @entity6 , @entity4 requiring rehospitalization, and device malfunctions than whites. Survival was high in non-whites and whites, at 94.1% vs 90.4% at 180 days and 89.2% vs 82.8% at 1 year, respectively, despite adjustment for baseline differences. CONCLUSIONS: Although @entity5 etiology differed between @entity0 and @entity0 and between whites and non-whites, sex and race were not factors that affected survival in @entity0 receiving the HVAD as BTT, which was high in all sub-groups.

title: An examination of survival by sex and race in the HeartWare Ventricular Assist Device for the Treatment of Advanced XXXX (ADVANCE) Bridge to Transplant (BTT) and continued access protocol trials.

answer: @entity5


abstract: UNASSIGNED: Proprotein convertase subtilisin/kexin (PCSK) enzymes cleave and convert their immature substrates into biologically active forms. Polymorphisms in the PCSK genes have been reported to associate with @entity0 diseases and phenotypes, including @entity1 and blood pressure (BP), and targeting PCSKs is considered a promising future form of drug therapy. PCSK processing is readily induced upon upregulation of the enzyme, but the genetic factors contributing to PCSK expression have not been thoroughly characterized. To gain a comprehensive understanding of the genetic regulation of PCSK expression, we performed, for the first time, a genome-wide expression quantitative trait loci (eQTL) analysis using mRNA expression in >1400 @entity0 peripheral blood samples from the Cardiovascular Risk in Young Finns Study and ca. ten million single-nucleotide polymorphisms (SNPs). The expression data showed clear expression for @entity3 , @entity2 , @entity4 and @entity5 (membrane-bound transcription factor peptidase, site 1) mRNAs in virtually all tested samples. A discovery analysis demonstrated a genome-wide significant (p  <  5  *  10(-8)) association with the selected PCSK probes for 1024 variants, which were located at ten independent loci. Of these loci, 5/10 could be confirmed to regulate PCSK expression in two additional and independent sample sets. Finally, a phenotypic analysis demonstrated that a novel cis-eQTL SNP @entity6 for @entity3 is strongly associated with both diastolic (p  =  0.012) and systolic (p  =  0.035) BP levels, as well as peripheral vascular resistance (p  =  0.003). These findings indicate that the expression of the PCSK enzymes is regulated by genetic factors, which have biological roles in health and disease.

title: A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for XXXX expression and blood pressure.

answer: @entity3


abstract: Ultrastructural studies were made of the early changes induced in left ventricular myocardium by @entity6 given to @entity1 either in drinking water (10.7 mM for 1 to 7 days) or by gavage (100 mg. per kg. per day for 1 or 2 days). @entity1 on the drinking water protocol developed myocardial alterations evident by light and electron microscopy within 2 days; those given @entity6 by gavage developed lesions after 24 hours. The earliest alteration consisted on @entity0 and "activation" of interstitial cells possessing an oblong shape, abundant rough endoplasmic reticulum, occasional lysosomes, a prominent Golgi apparatus, few mitochondria, and large irregular nuclei (often with a typical "Anitschkow" morphology). Mitoses of these interstitial cells were frequent. Mitoses were also observed in endothelial cells. Acute @entity3 , which developed after 6 days of the drinking water protocol or one gavage dose, was characterized by focal @entity4 with lipid droplet accumulation and Z-line distortion and dissolution, especially prominent in areas of intercellular junctions. These focal lesions coalesced to involve whole myocytes with severe @entity4 and contraction band @entity2 . Mitochondria of severely altered cells were swollen and contained dense inclusions. Nuclei had prominent nucleoli and, in severely @entity2 cells, clumped and irregular chromatin. Large areas of @entity2 myocardium showed extravasated red blood cells and minimal intra- and extracellular deposition of fibrin. Vascular @entity2 or @entity5 was not seen. A prompt inflammatory infiltrate was composed predominantly of macrophages invading @entity2 myocytes, with occasional polymorphonuclear neutrophilic and eosinophilic leukocytes.

title: Ultrastructural alterations in XXXX - induced @entity3 : early lesions.

answer: @entity6


abstract: Ultrastructural studies were made of the early changes induced in left ventricular myocardium by @entity6 given to @entity1 either in drinking water (10.7 mM for 1 to 7 days) or by gavage (100 mg. per kg. per day for 1 or 2 days). @entity1 on the drinking water protocol developed myocardial alterations evident by light and electron microscopy within 2 days; those given @entity6 by gavage developed lesions after 24 hours. The earliest alteration consisted on @entity0 and "activation" of interstitial cells possessing an oblong shape, abundant rough endoplasmic reticulum, occasional lysosomes, a prominent Golgi apparatus, few mitochondria, and large irregular nuclei (often with a typical "Anitschkow" morphology). Mitoses of these interstitial cells were frequent. Mitoses were also observed in endothelial cells. Acute @entity3 , which developed after 6 days of the drinking water protocol or one gavage dose, was characterized by focal @entity4 with lipid droplet accumulation and Z-line distortion and dissolution, especially prominent in areas of intercellular junctions. These focal lesions coalesced to involve whole myocytes with severe @entity4 and contraction band @entity2 . Mitochondria of severely altered cells were swollen and contained dense inclusions. Nuclei had prominent nucleoli and, in severely @entity2 cells, clumped and irregular chromatin. Large areas of @entity2 myocardium showed extravasated red blood cells and minimal intra- and extracellular deposition of fibrin. Vascular @entity2 or @entity5 was not seen. A prompt inflammatory infiltrate was composed predominantly of macrophages invading @entity2 myocytes, with occasional polymorphonuclear neutrophilic and eosinophilic leukocytes.

title: Ultrastructural alterations in @entity6 - induced XXXX : early lesions.

answer: @entity3


abstract: BACKGROUND: The bilayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE: To examine the feasibility of gelatin sealing sheets using a @entity3 @entity4 model. METHODS: In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in @entity1 . For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of @entity3 were pricked with syringe needle to make a small hole and a gelatin (i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop @entity4 (n=8). After discontinuation of the @entity4 , the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS: From the degradation study, 4 h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, @entity4 from the needle hole on @entity3 femoral arteries was effectively stopped. @entity2 and @entity0 at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS: The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing @entity2 .

title: Gelatin sealing sheet for arterial hemostasis and anti-adhesion in vascular surgery: a XXXX model study.

answer: @entity3


abstract: BACKGROUND _ AIMS: Extracorporeal blood purification systems for supportive therapy of @entity4 are widely used. We developed a novel blood purification system, named @entity9 's artificial liver system ( @entity9 - @entity6 ), which couples low-volume plasma exchange ( @entity0 ) with plasma filtration adsorption (PFA). This study aims to evaluate the efficacy of our novel system in @entity5 with @entity3 ( @entity3 ). METHODS: Thirty-two @entity5 were infused with @entity10 (1.3g/kg) to induce @entity3 . All animals were equally and randomly divided into four groups: the @entity3 control group received intensive care, the PFA group underwent five hour plasma recycling filtration and adsorption purification, the @entity0 group received one hour @entity0 , and the @entity9 - @entity6 group underwent one hour @entity0 , followed by five hour PFA. Intervention was initiated 36hours after drug administration. The efficacy of each treatment was assessed by survival time and improvement in hematological, biochemical, and immunohistological parameters. RESULTS: @entity5 in the Li- @entity6 group survived longer than those in the other groups (p<0.001, @entity3 control: 60  2h; PFA group: 74  2h; @entity0 group: 75  2h; and @entity9 - @entity6 group: 90  3h). Liver enzyme, @entity2 , @entity8 and blood @entity7 levels were decreased significantly after @entity9 - @entity6 treatment, and increases in inflammatory cytokines were ameliorated. A higher hepatocyte regeneration index was also observed in the Li- @entity6 group. CONCLUSION: Our novel @entity9 - @entity6 could expedite @entity1 and improve survival time; hence, it could be promising for treating @entity3 .

title: Efficacy of coupled low-volume plasma exchange with plasma filtration adsorption in treating XXXX with @entity3 : A randomised study.

answer: @entity5


abstract: BACKGROUND _ AIMS: Extracorporeal blood purification systems for supportive therapy of @entity4 are widely used. We developed a novel blood purification system, named @entity9 's artificial liver system ( @entity9 - @entity6 ), which couples low-volume plasma exchange ( @entity0 ) with plasma filtration adsorption (PFA). This study aims to evaluate the efficacy of our novel system in @entity5 with @entity3 ( @entity3 ). METHODS: Thirty-two @entity5 were infused with @entity10 (1.3g/kg) to induce @entity3 . All animals were equally and randomly divided into four groups: the @entity3 control group received intensive care, the PFA group underwent five hour plasma recycling filtration and adsorption purification, the @entity0 group received one hour @entity0 , and the @entity9 - @entity6 group underwent one hour @entity0 , followed by five hour PFA. Intervention was initiated 36hours after drug administration. The efficacy of each treatment was assessed by survival time and improvement in hematological, biochemical, and immunohistological parameters. RESULTS: @entity5 in the Li- @entity6 group survived longer than those in the other groups (p<0.001, @entity3 control: 60  2h; PFA group: 74  2h; @entity0 group: 75  2h; and @entity9 - @entity6 group: 90  3h). Liver enzyme, @entity2 , @entity8 and blood @entity7 levels were decreased significantly after @entity9 - @entity6 treatment, and increases in inflammatory cytokines were ameliorated. A higher hepatocyte regeneration index was also observed in the Li- @entity6 group. CONCLUSION: Our novel @entity9 - @entity6 could expedite @entity1 and improve survival time; hence, it could be promising for treating @entity3 .

title: Efficacy of coupled low-volume plasma exchange with plasma filtration adsorption in treating @entity5 with XXXX : A randomised study.

answer: @entity3


abstract: The effect of race on @entity0 outcome is confounded by @entity2 and treatment heterogeneity. We examined a cohort of @entity1 with @entity0 treated uniformly with neoadjuvant chemotherapy to identify factors associated with racial differences in chemotherapeutic response and long-term survival. Using a prospective database, we identified @entity1 with @entity0 treated with neoadjuvant chemotherapy from 1998 to 2011. Race was categorized @entity6 ( @entity6 ) or non- @entity6 . Preplanned subtype analyses were stratified by @entity7 ( @entity7 ) and @entity5 . Pathologic response to chemotherapy (pCR), time to recurrence (TTR), and @entity4 ( @entity4 ) were assessed using logistic regression, Kaplan-Meier method, and Cox proportional hazards regression analyses. Of 349 @entity1 identified, 102 (29 %) were @entity6 , who were younger (p = 0.03), more @entity3 (p < 0.001), and less likely to have @entity7 +/ @entity5 - @entity2 (p = 0.01). No significant differences in pCR rate by race were found. At median follow-up of 6.5 years, @entity6 had worse TTR (hazard ratio 1.51, 95 % CI 1.02-2.24), which was attenuated in multivariable modeling, and there was no significant difference in @entity4 . When stratified by @entity7 , worse outcomes were limited to @entity7 + @entity6 (TTR hazard ratio 1.85, 95 % CI 1.09-3.14; @entity4 hazard ratio 2.42 95 % CI 1.37-4.28), which remained significant in multivariable analysis including pCR rate and BMI. With long-term follow-up, racial disparity in outcome was limited to @entity7 + @entity0 , with no apparent contribution of chemotherapy sensitivity. This suggests that disparity root causes may be driven by @entity7 + factors such as unmeasured molecular differences, endocrine therapy sensitivity, or adherence.

title: Race, response to chemotherapy, and outcome within clinical XXXX subtypes.

answer: @entity0


abstract: BACKGROUND: There is often a discrepancy between results from endoscopic forceps biopsy and resected specimen. We aimed to identify endoscopic predictors for undifferentiated histology in differentiated @entity1 prior to endoscopic resection. METHODS: Medical records of the @entity0 who underwent endoscopic submucosal dissection (ESD) for biopsy-proven differentiated @entity1 at Seoul National University Hospital between July 2005 and July 2014 were retrospectively reviewed. The lesions were divided into two groups based on the final histologic result of ESD: differentiated @entity2 (DA group) and undifferentiated histology (UDH group). The discordant rate, clinicopathologic characteristics, and endoscopic factors were analyzed. RESULTS: A total of 1641 early @entity1 from 1615 @entity0 were included. Of these, 1556 (94.8  %) were diagnosed as DA and 85 (5.2  %) as UDH. The mean age was significantly lower, and number of @entity0 was higher in the UDH group than in the DA group. On multivariate analysis, age <65  years [odds ratio (OR) 1.75, 95  % confidence interval (CI) 1.10-2.80], female sex (OR 3.19, 95  % CI 2.00-5.08), endoscopic size >10  mm (OR 1.81, 95  % CI 1.12-2.92), depressed type (OR 2.85, 95  % CI 1.56-5.21), nodularity (OR 2.83, 95  % CI 1.59-5.05), and whitish discoloration (OR 19.64, 95  % CI 6.98-55.25) were independent predictors. CONCLUSIONS: Female sex, age <65  years, large endoscopic size, depressed morphology, surface nodularity, and whitish discoloration were predictors for UDH. Meticulous attention should be paid to the lesions with these endoscopic predictors for determining the risk of UDH prior to endoscopic resection.

title: Endoscopic predictors for undifferentiated histology in differentiated XXXX prior to endoscopic resection.

answer: @entity1


abstract: Two cases of @entity1 in the @entity3 are reported. The two @entity0 were thoroughbreds. One was eight and the other thirteen years old. The mares were in heat and were brought to the service (stud) station to be mated. Both @entity0 were nursing a foal. One was a four-week-old foal and the other was seven weeks old. The @entity2 level of the serum had dropped in the two @entity0 , to 4.0 mg and 5.4 per ml. respectively. The @entity4 level was 1.0 mg and 1.9 mg per 100 ml. respectively. The animals responded satisfactorily to intravenous infusion of @entity6 and @entity5 . One of the mares was also give 10 1. of physiological saline a few times.

title: [Two cases of XXXX in the @entity3 (author's transl)].

answer: @entity1


abstract: Two cases of @entity1 in the @entity3 are reported. The two @entity0 were thoroughbreds. One was eight and the other thirteen years old. The mares were in heat and were brought to the service (stud) station to be mated. Both @entity0 were nursing a foal. One was a four-week-old foal and the other was seven weeks old. The @entity2 level of the serum had dropped in the two @entity0 , to 4.0 mg and 5.4 per ml. respectively. The @entity4 level was 1.0 mg and 1.9 mg per 100 ml. respectively. The animals responded satisfactorily to intravenous infusion of @entity6 and @entity5 . One of the mares was also give 10 1. of physiological saline a few times.

title: [Two cases of @entity1 in the XXXX (author's transl)].

answer: @entity3


abstract: UNASSIGNED: Background: @entity2 is a common problem of @entity0 on @entity5 intensive care units. Only little data exists in literature and there are no clinical guidelines. The aim of this national survey was to assess criteria for correction of @entity2 in @entity5 @entity0 and if there were effects to be observed. Methods: We designed an online survey and sent it to 304 German @entity0 's hospitals. 101 questionnaires were included in our study. Results: The question "How often do you buffer on your ward a week?" was answered 63 times with "zero". In perinatal @entity3 newborns with gestation age over 36+0 weeks 4% of the neonatologists would frequently perform a correction of @entity2 , 74.3% would do it rarely and 21.8% never. In syndrome of @entity6 28.4% would correct @entity2 frequently, 42.0% would correct it rarely and 29.5% would never correct it. In case of @entity1 8.7% would correct @entity2 frequently, 70.7% would do it rarely and 20.7% would never correct it. 75.2% of the @entity0 distinguish in buffering a premature or a mature @entity0 . 44.4% of neonatologists saw an improvement of the clinical status of the @entity0 after buffering. 38.3% saw different effects, 16.0% saw no changes and 1.2% saw a worsening of the clinical status. 49.4% of those questioned saw side effects after using @entity4 as a buffer. Conclusion: Correction of @entity2 with a buffer is rarely performed on German neonatology wards. The indication of buffering depends on the clinical picture and its underlying problem. Benefits from buffering were seen, as well as side effects.

title: [Correction of XXXX in Neonatal Intensive-care Medicine: A National Survey].

answer: @entity2


abstract: BACKGROUND: International @entity2 treatment guidelines recommend a minimum 10 to 14 days' intravenous antibiotic therapy (intensive phase), followed by 3 to 6 months' oral therapy (eradication phase). This approach is associated with rates of relapse, defined as recurrence following the eradication phase, that can exceed 5%. Rates of recrudescence, defined as recurrence during the eradication phase, have not previously been reported. In response to low eradication phase completion rates in Australia, a local guideline has evolved over the last ten years recommending a longer minimum intensive phase duration for many cases of @entity2 . METHODOLOGY/ PRINCIPAL FINDINGS: This retrospective cohort study reviews antibiotic duration for the first episode of care for all @entity0 diagnosed with @entity2 and surviving the intensive phase during a recent three year period in the tropical north of Australia's Northern Territory; we also review adherence to the current local guideline and treatment outcomes. Of 215 first episodes of @entity2 surviving the intensive phase, the median (interquartile range) intensive phase duration was 26 (14-34) days. One hundred and eight (50.2%) @entity0 completed eradication therapy; 58 (27.0%) @entity0 took no eradication therapy. At 28 months' follow-up, one (0.5%) relapse and eleven (5.1%) recrudescences had occurred. On exact logistic regression analysis, the only independent risk factors for recrudescence were self-discharge during the intensive phase (odds ratio 6.2 [95% confidence interval 1.2-30.0]) and @entity1 (odds ratio 5.3 [95% confidence interval 1.1-25.7]). CONCLUSIONS/ SIGNIFICANCE: Relapsed @entity2 is rare in @entity0 who receive a minimum intensive phase duration specified by our guideline and extended according to clinical progress. Recrudescence rates may improve with reductions in rates of self-discharge. Given the low relapse rate despite a high rate of eradication therapy non-adherence, the duration and necessity of eradication therapy for different @entity0 after guideline-concordant intensive therapy should be evaluated further.

title: Intravenous Therapy Duration and Outcomes in XXXX : A New Treatment Paradigm.

answer: @entity2


abstract: UNASSIGNED: @entity2 is a @entity9 defined by the growth of endometrium outside of the uterus. Although @entity2 contributes to 50% of female @entity4 cases, medical treatments are incompatible with pregnancy. Angiogenesis, the growth of blood vessels from existing vasculature, plays a crucial role in endometriotic lesion growth and survival. Previously, we demonstrated the effectiveness of @entity10 analog, @entity11 (Abbott Laboratories) to inhibit @entity5 in @entity1 . We have now evaluated the trans-generational implications of @entity11 treatment before and during @entity1 pregnancy. We hypothesized that @entity11 would @entity3 vasculature without affecting pregnancy, offspring development, or ovarian and uterine vascularity in @entity1 . @entity2 was induced using @entity0 endometrium in b-estradiol-primed BALB/c-Rag-2-/-Il2ry-/- @entity1 receiving intraperitoneal injections of @entity11 (25 mg/kg) or 5% dextrose control for 21 days. Ultrasound assessment of lesion vascularization revealed a reduction in blood flow supplying treated lesions. Excised @entity11 treated lesions stained for @entity8 + endothelial cells exhibited a decrease in microvessel density. Following confirmation of estrous cycling, @entity1 were bred and treated with @entity11 on gestation days 7, 9, 11, 13, 15, 17, and 19. @entity11 did not affect estrous cycling or pregnancy parameters including litter size across generations and offspring @entity6 . Quantification of angiogenic cytokine plasma levels revealed no significant differences between treatment groups. @entity7 staining of the uterus and ovary revealed no observable effects of @entity11 . Similarly, no obvious histological anomalies were observed in the kidney, liver, ovary, or uterus following @entity11 treatment. These results suggest that @entity11 effectively inhibit @entity5 without affecting trans-generational pregnancy outcomes in @entity1 .

title: Compatibility of a Novel @entity10 Analog with Fertility and Pregnancy in a Xenograft @entity1 Model of XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity2 is a @entity9 defined by the growth of endometrium outside of the uterus. Although @entity2 contributes to 50% of female @entity4 cases, medical treatments are incompatible with pregnancy. Angiogenesis, the growth of blood vessels from existing vasculature, plays a crucial role in endometriotic lesion growth and survival. Previously, we demonstrated the effectiveness of @entity10 analog, @entity11 (Abbott Laboratories) to inhibit @entity5 in @entity1 . We have now evaluated the trans-generational implications of @entity11 treatment before and during @entity1 pregnancy. We hypothesized that @entity11 would @entity3 vasculature without affecting pregnancy, offspring development, or ovarian and uterine vascularity in @entity1 . @entity2 was induced using @entity0 endometrium in b-estradiol-primed BALB/c-Rag-2-/-Il2ry-/- @entity1 receiving intraperitoneal injections of @entity11 (25 mg/kg) or 5% dextrose control for 21 days. Ultrasound assessment of lesion vascularization revealed a reduction in blood flow supplying treated lesions. Excised @entity11 treated lesions stained for @entity8 + endothelial cells exhibited a decrease in microvessel density. Following confirmation of estrous cycling, @entity1 were bred and treated with @entity11 on gestation days 7, 9, 11, 13, 15, 17, and 19. @entity11 did not affect estrous cycling or pregnancy parameters including litter size across generations and offspring @entity6 . Quantification of angiogenic cytokine plasma levels revealed no significant differences between treatment groups. @entity7 staining of the uterus and ovary revealed no observable effects of @entity11 . Similarly, no obvious histological anomalies were observed in the kidney, liver, ovary, or uterus following @entity11 treatment. These results suggest that @entity11 effectively inhibit @entity5 without affecting trans-generational pregnancy outcomes in @entity1 .

title: Compatibility of a Novel XXXX Analog with Fertility and Pregnancy in a Xenograft @entity1 Model of @entity2 .

answer: @entity10


abstract: UNASSIGNED: @entity2 is a @entity9 defined by the growth of endometrium outside of the uterus. Although @entity2 contributes to 50% of female @entity4 cases, medical treatments are incompatible with pregnancy. Angiogenesis, the growth of blood vessels from existing vasculature, plays a crucial role in endometriotic lesion growth and survival. Previously, we demonstrated the effectiveness of @entity10 analog, @entity11 (Abbott Laboratories) to inhibit @entity5 in @entity1 . We have now evaluated the trans-generational implications of @entity11 treatment before and during @entity1 pregnancy. We hypothesized that @entity11 would @entity3 vasculature without affecting pregnancy, offspring development, or ovarian and uterine vascularity in @entity1 . @entity2 was induced using @entity0 endometrium in b-estradiol-primed BALB/c-Rag-2-/-Il2ry-/- @entity1 receiving intraperitoneal injections of @entity11 (25 mg/kg) or 5% dextrose control for 21 days. Ultrasound assessment of lesion vascularization revealed a reduction in blood flow supplying treated lesions. Excised @entity11 treated lesions stained for @entity8 + endothelial cells exhibited a decrease in microvessel density. Following confirmation of estrous cycling, @entity1 were bred and treated with @entity11 on gestation days 7, 9, 11, 13, 15, 17, and 19. @entity11 did not affect estrous cycling or pregnancy parameters including litter size across generations and offspring @entity6 . Quantification of angiogenic cytokine plasma levels revealed no significant differences between treatment groups. @entity7 staining of the uterus and ovary revealed no observable effects of @entity11 . Similarly, no obvious histological anomalies were observed in the kidney, liver, ovary, or uterus following @entity11 treatment. These results suggest that @entity11 effectively inhibit @entity5 without affecting trans-generational pregnancy outcomes in @entity1 .

title: Compatibility of a Novel @entity10 Analog with Fertility and Pregnancy in a Xenograft XXXX Model of @entity2 .

answer: @entity1


abstract: BACKGROUND: Much has been written about injuries sustained by US and coalition soldiers during the Global War on Terrorism campaigns. However, injuries to civilians, including @entity0 , have been less well documented. OBJECTIVE: To describe the epidemiologic features and outcomes associated with isolated severe @entity1 in @entity0 during Operations Enduring Freedom and Iraqi Freedom (OEF and @entity3 ). METHODS: A retrospective review of @entity0 (<18 years old) in the Joint Theater Trauma Registry with isolated @entity1 (defined as an Abbreviated Injury Score Severity Code >3) and treated at a US combat support hospital in Iraq or Afghanistan (2004-2012). The primary outcome was in-hospital mortality. RESULTS: We identified 647 @entity0 with severe isolated @entity1 : 337 from OEF, 268 from @entity3 , and 42 nontheater specific. Most were @entity0 (76%; median age = 8 years). Penetrating injuries were most common (60.6%). Overall, 330 (51%) @entity0 underwent a craniotomy/craniectomy; 156 (24.1%) succumbed to their injuries. Admission Glasgow @entity2 Score was predictive of survival among the entire cohort and each of the individual conflicts. Male sex also significantly increased the odds of survival for the entire group and OEF, but not for @entity3 . Closed- @entity1 improved the predictive ability of our model but did not reach statistical significance as an independent factor. CONCLUSION: This is the largest study of combat-related isolated @entity1 in @entity0 . Admission Glasgow @entity2 Score and male sex were found to be predictive of survival. Assets to comprehensively care for the pediatric @entity0 should be established early in future conflicts. ABBREVIATIONS: CI, confidence intervalGCS, Glasgow @entity2 ScoreICP, intracranial pressureIED, improvised explosive deviceJTTR, Joint Theater Trauma RegistryLN, local nationalMTF, military treatment facilityOEF, Operation Enduring FreedomOIF, Operation Iraqi Freedom.

title: Severe XXXX During the Iraq and Afghanistan Conflicts.

answer: @entity1


abstract: On the basis of an own @entity6 combined with @entity7 of the corpus callosum problems of the genesis of @entity3 and its coverings are discussed. Colectomy was performed in a 37-year-old @entity0 because of @entity6 . His sister suffers from the same disease. The @entity0 died 25 d after the operation as a result of @entity4 . As an incidental finding, the autopsy revealed a @entity7 with a diameter of approximately 1 cm. Histologically the growth showed the typical structure of a @entity5 and contained a remarkably high number of blood vessels with proliferations of the intima and @entity2 of the walls. At the periphery small calcifications were demonstrated. In the adjacent brain tissue angiomatous proliferations of blood vessels were observed. Furthermore, disturbances of the gross structure of the gyri cinguli and other gyri of the median surface of the brain were found. The histological examination discovered marked irregularities of the single layers of the cerebral cortex. It is suggested that developmental and genetic factors might play a significant role in the genesis of @entity1 of the CNS.

title: [ XXXX of the brain. Contribution to the problemacy of @entity5 (author's transl)].

answer: @entity7


abstract: On the basis of an own @entity6 combined with @entity7 of the corpus callosum problems of the genesis of @entity3 and its coverings are discussed. Colectomy was performed in a 37-year-old @entity0 because of @entity6 . His sister suffers from the same disease. The @entity0 died 25 d after the operation as a result of @entity4 . As an incidental finding, the autopsy revealed a @entity7 with a diameter of approximately 1 cm. Histologically the growth showed the typical structure of a @entity5 and contained a remarkably high number of blood vessels with proliferations of the intima and @entity2 of the walls. At the periphery small calcifications were demonstrated. In the adjacent brain tissue angiomatous proliferations of blood vessels were observed. Furthermore, disturbances of the gross structure of the gyri cinguli and other gyri of the median surface of the brain were found. The histological examination discovered marked irregularities of the single layers of the cerebral cortex. It is suggested that developmental and genetic factors might play a significant role in the genesis of @entity1 of the CNS.

title: [ @entity7 of the brain. Contribution to the problemacy of XXXX (author's transl)].

answer: @entity5


abstract: The effects of low concentration @entity2 in continuous lumbar epidural @entity1 during labor and delivery, were evaluated in 21 subjects. The final analysis was made on 18 parturientis, 9 receiving 1.5% (group A) and 9 1.33% @entity2 (group B), in a standard dose of 7-8 ml (first test dose 2-3 ml), and of 12 ml for the second stage of labor. Onset of @entity1 occurred 7.4 +/- 1.2 (mean +/- S.D.) (group A) and 9.6 +/- 1.8 min. (group B) after injection (difference significant). Mean interval between first and second doses was 50.5 +/- 6.3 (group A) and 47.5 +/- 10.8 (group B) min. (difference N.S.). In group A 6 @entity0 and in group B only 1 @entity0 had a temporarily decrease in bloodpressure below 100 mm Hg. During routine monitoring, pathological F.H.R. patterns were recorded in 2 cases. Apgar scores and acid-base parameters were within normal limits in both groups (difference N.S.).

title: Use of @entity2 for obstetric XXXX .

answer: @entity1


abstract: The effects of low concentration @entity2 in continuous lumbar epidural @entity1 during labor and delivery, were evaluated in 21 subjects. The final analysis was made on 18 parturientis, 9 receiving 1.5% (group A) and 9 1.33% @entity2 (group B), in a standard dose of 7-8 ml (first test dose 2-3 ml), and of 12 ml for the second stage of labor. Onset of @entity1 occurred 7.4 +/- 1.2 (mean +/- S.D.) (group A) and 9.6 +/- 1.8 min. (group B) after injection (difference significant). Mean interval between first and second doses was 50.5 +/- 6.3 (group A) and 47.5 +/- 10.8 (group B) min. (difference N.S.). In group A 6 @entity0 and in group B only 1 @entity0 had a temporarily decrease in bloodpressure below 100 mm Hg. During routine monitoring, pathological F.H.R. patterns were recorded in 2 cases. Apgar scores and acid-base parameters were within normal limits in both groups (difference N.S.).

title: Use of XXXX for obstetric @entity1 .

answer: @entity2


abstract: OBJECTIVE: The effect of different exercise programs on cervical flexor muscles dimensions in @entity0 with @entity3 is yet to be demonstrated. The purpose of this study was to assess the effect of two exercise programs; @entity4 ( @entity4 ) and @entity2 ( @entity2 ), on flexor muscles dimensions in @entity0 with @entity3 . METHODS: Following ethical approval, 60 @entity0 were randomly assigned into either a @entity4 group or a @entity2 group. @entity0 in the @entity4 group were given @entity4 exercises and those in the @entity2 group received @entity2 exercises. All @entity0 received interventions for a period of ten weeks. @entity1 intensity and functional disability were assessed using numerical @entity1 rate scale and neck disability index, respectively. Dimensions of longus colli (LC) and sternoclidomastoid (SCM) muscles were measured using ultrasonography (US). All measurements were taken before and after interventions. RESULTS: Following intervention, the @entity4 group demonstrated a significant increase in LC muscle dimensions including cross sectional area, width and thickness compared with the @entity2 group. A statistically significant increase was found on SCM thickness in the @entity2 group. Following intervention, SCM thickness measurement in the @entity4 group showed no significant changes. Statistically significant decrease on @entity1 intensity and disability were also found in both groups. CONCLUSION: Present findings demonstrated that @entity4 program which specifically recruiting deep cervical flexor muscles increased LC muscle dimension significantly and @entity2 program as an endurance training program increased SCM thickness.

title: The effect of different exercise programs on cervical flexor muscles dimensions in @entity0 with XXXX .

answer: @entity3


abstract: OBJECTIVE: The effect of different exercise programs on cervical flexor muscles dimensions in @entity0 with @entity3 is yet to be demonstrated. The purpose of this study was to assess the effect of two exercise programs; @entity4 ( @entity4 ) and @entity2 ( @entity2 ), on flexor muscles dimensions in @entity0 with @entity3 . METHODS: Following ethical approval, 60 @entity0 were randomly assigned into either a @entity4 group or a @entity2 group. @entity0 in the @entity4 group were given @entity4 exercises and those in the @entity2 group received @entity2 exercises. All @entity0 received interventions for a period of ten weeks. @entity1 intensity and functional disability were assessed using numerical @entity1 rate scale and neck disability index, respectively. Dimensions of longus colli (LC) and sternoclidomastoid (SCM) muscles were measured using ultrasonography (US). All measurements were taken before and after interventions. RESULTS: Following intervention, the @entity4 group demonstrated a significant increase in LC muscle dimensions including cross sectional area, width and thickness compared with the @entity2 group. A statistically significant increase was found on SCM thickness in the @entity2 group. Following intervention, SCM thickness measurement in the @entity4 group showed no significant changes. Statistically significant decrease on @entity1 intensity and disability were also found in both groups. CONCLUSION: Present findings demonstrated that @entity4 program which specifically recruiting deep cervical flexor muscles increased LC muscle dimension significantly and @entity2 program as an endurance training program increased SCM thickness.

title: The effect of different exercise programs on cervical flexor muscles dimensions in XXXX with @entity3 .

answer: @entity0


abstract: BACKGROUND AND AIMS: The frequency of @entity2 during ERCP with cholangioscopy has not been well studied. There are no formal guidelines regarding antibiotic prophylaxis before ERCP with cholangioscopy. The aim was to estimate the frequency of @entity2 and subsequent infectious adverse events after ERCP with cholangioscopy. METHODS: This prospective nonrandomized study performed in a single tertiary referral center included adult @entity0 who were undergoing ERCP with cholangioscopic examination of the common bile duct. Blood cultures were drawn from @entity0 before the procedure and 5 and 30 minutes after the procedure. Antibiotics were not given before or after the procedure. @entity0 were followed up after 24 hours and 1 week after the procedure for infectious adverse events. The primary outcome was @entity2 rate, and secondary outcomes were @entity1 rate and adverse events. RESULTS: Fifty-seven @entity0 were enrolled in the study with 60 procedures performed. The first procedure from each @entity0 was considered in the analysis, and thus we included 57 @entity0 with 57 procedures in this study analysis. Postprocedure @entity2 was seen in 5 of 57 procedures (8.8%; 95% confidence interval, 2.9%-19.3%). Four @entity0 were readmitted with @entity1 (7.0%). @entity2 was more common in @entity0 who had cholangioscopy with biopsy sampling compared with @entity0 who had cholangioscopy without biopsy sampling (P  =  .011). @entity1 was significantly more common in @entity0 with @entity2 than in those @entity0 with a negative blood culture (P  = .035). CONCLUSION: ERCP with cholangioscopy is associated with a @entity2 rate of 8.8% and a @entity1 rate of 7.0%. Preprocedural antibiotics may be considered before cholangioscopy, especially if tissue acquisition with biopsy sampling is expected. (Clinical trial registration number: NCT01673269.).

title: A prospective study of the risk of XXXX in directed cholangioscopic examination of the common bile duct.

answer: @entity2


abstract: BACKGROUND: After pulmonary resection, @entity0 with @entity1 who have @entity5 ( @entity5 ) have been reported to have higher pulmonary morbidity and mortality and poorer outcomes than @entity0 without @entity5 . However, whether morbidity, mortality, and outcomes differ according to the subtype of @entity6 ( @entity6 ) remains unclear. METHODS: The clinical records of 678 @entity0 with @entity3 who underwent pulmonary resection were reviewed retrospectively. A total of 103 @entity0 had @entity6 and were classified into an @entity5 group and a non- @entity5 group in accordance with the 2011 statement. RESULTS: The @entity5 group comprised 46 @entity0 , and the non- @entity5 group comprised 57. The 5-year survival rate was significantly higher in the non- @entity5 group (53.2%) than in the @entity5 group (22.1%; p  = 0.0093). Cause of @entity2 was @entity6 -related @entity4 in 26.1% (12 of 46) of the @entity0 in the @entity5 group as compared with 7.0% (4 of 57) of @entity0 in the non- @entity5 group (p  = 0.008). Multivariate Cox analysis indicated that @entity5 was a significant predictor of long-term survival (hazard ratio 1.910, 95% confidence interval: 1.102 to 3.313; p  = 0.021). CONCLUSIONS: @entity5 is independently associated with poorer overall survival in @entity0 with @entity1 who undergo pulmonary resection. The decision whether to perform surgery in @entity0 who have @entity1 with @entity6 should therefore take into account the subtype of @entity6 and the poorer outcomes associated with @entity5 .

title: Pulmonary Resection for XXXX in @entity0 With @entity6 .

answer: @entity1


abstract: BACKGROUND: After pulmonary resection, @entity0 with @entity1 who have @entity5 ( @entity5 ) have been reported to have higher pulmonary morbidity and mortality and poorer outcomes than @entity0 without @entity5 . However, whether morbidity, mortality, and outcomes differ according to the subtype of @entity6 ( @entity6 ) remains unclear. METHODS: The clinical records of 678 @entity0 with @entity3 who underwent pulmonary resection were reviewed retrospectively. A total of 103 @entity0 had @entity6 and were classified into an @entity5 group and a non- @entity5 group in accordance with the 2011 statement. RESULTS: The @entity5 group comprised 46 @entity0 , and the non- @entity5 group comprised 57. The 5-year survival rate was significantly higher in the non- @entity5 group (53.2%) than in the @entity5 group (22.1%; p  = 0.0093). Cause of @entity2 was @entity6 -related @entity4 in 26.1% (12 of 46) of the @entity0 in the @entity5 group as compared with 7.0% (4 of 57) of @entity0 in the non- @entity5 group (p  = 0.008). Multivariate Cox analysis indicated that @entity5 was a significant predictor of long-term survival (hazard ratio 1.910, 95% confidence interval: 1.102 to 3.313; p  = 0.021). CONCLUSIONS: @entity5 is independently associated with poorer overall survival in @entity0 with @entity1 who undergo pulmonary resection. The decision whether to perform surgery in @entity0 who have @entity1 with @entity6 should therefore take into account the subtype of @entity6 and the poorer outcomes associated with @entity5 .

title: Pulmonary Resection for @entity1 in @entity0 With XXXX .

answer: @entity6


abstract: BACKGROUND: After pulmonary resection, @entity0 with @entity1 who have @entity5 ( @entity5 ) have been reported to have higher pulmonary morbidity and mortality and poorer outcomes than @entity0 without @entity5 . However, whether morbidity, mortality, and outcomes differ according to the subtype of @entity6 ( @entity6 ) remains unclear. METHODS: The clinical records of 678 @entity0 with @entity3 who underwent pulmonary resection were reviewed retrospectively. A total of 103 @entity0 had @entity6 and were classified into an @entity5 group and a non- @entity5 group in accordance with the 2011 statement. RESULTS: The @entity5 group comprised 46 @entity0 , and the non- @entity5 group comprised 57. The 5-year survival rate was significantly higher in the non- @entity5 group (53.2%) than in the @entity5 group (22.1%; p  = 0.0093). Cause of @entity2 was @entity6 -related @entity4 in 26.1% (12 of 46) of the @entity0 in the @entity5 group as compared with 7.0% (4 of 57) of @entity0 in the non- @entity5 group (p  = 0.008). Multivariate Cox analysis indicated that @entity5 was a significant predictor of long-term survival (hazard ratio 1.910, 95% confidence interval: 1.102 to 3.313; p  = 0.021). CONCLUSIONS: @entity5 is independently associated with poorer overall survival in @entity0 with @entity1 who undergo pulmonary resection. The decision whether to perform surgery in @entity0 who have @entity1 with @entity6 should therefore take into account the subtype of @entity6 and the poorer outcomes associated with @entity5 .

title: Pulmonary Resection for @entity1 in XXXX With @entity6 .

answer: @entity0


abstract: BACKGROUND: Improved critical care, pre-operative optimization, and the advent of endovascular surgery (EVAR) have improved 30 day mortality for elective @entity2 ( @entity2 ) repair. It remains unknown whether this has translated into improvements in long-term survival, particularly because these factors have also encouraged the treatment of older @entity0 with greater comorbidity. The aim of this study was to quantify how 5 year survival after elective @entity2 repair has changed over time. METHODS: A systematic review was performed identifying studies reporting 5 year survival after elective infrarenal @entity2 repair. An electronic search of the Embase and Medline databases was conducted to January 2014. Thirty-six studies, 60 study arms, and 107,814 @entity0 were identified. Meta-analyses were conducted to determine 5 year survival and to report whether 5 year survival changed over time. RESULTS: Five-year survival was 69% (95% CI 67 to 71%, I(2) = 87%). Meta-regression on study midpoint showed no improvement in 5 year survival over the period 1969-2011 (log OR -0.001, 95% CI -0.014-0.012). Larger average @entity1 diameter was associated with poorer 5 year survival (adjusted log OR -0.058, 95% CI -0.095 to -0.021, I(2) = 85%). Older average @entity0 age at surgery was associated with poorer 5 year survival (adjusted log OR -0.118, 95% CI -0.142 to -0.094, I(2) = 70%). After adjusting for average @entity0 age, an improvement in 5 year survival over the period that these data spanned was obtained (adjusted log OR 0.027, 95% CI 0.012 to 0.042). CONCLUSION: Five-year survival remains poor after elective @entity2 repair despite advances in short-term outcomes and is associated with @entity2 diameter and @entity0 age at the time of surgery. Age-adjusted survival appears to have improved; however, this cohort as a whole continues to have poor long-term survival. Research in this field should attempt to improve the life expectancy of @entity0 with repaired @entity2 and to optimise @entity0 selection.

title: Systematic Review and Meta-analysis of Long-term survival After Elective Infrarenal XXXX Repair 1969-2011: 5 Year Survival Remains Poor Despite Advances in Medical Care and Treatment Strategies.

answer: @entity2


abstract: UNASSIGNED: A total of 72 laying hens were used to investigate the effect of probiotic and @entity3 on body @entity0 , tibia ash, antibody production against @entity2 red blood cell (SRBC), heterophile-to-lymphocyte (H/L) ratio and gut microbiota in a common moulting method for 14 d. Hens were randomly allocated to 6 experimental groups consisting of (i) full feed (FF), (ii) feed withdrawal (FW), (iii) FW with @entity1 ( @entity4 ), (iv) FW with @entity4 and offering 7  g/lit @entity3 in drinking water (CaL), (v) FW with @entity4 and offering 1  g/lit probiotic in drinking water (CaP), and (vi) FW with @entity4 and offering a mixture of @entity3 and probiotic in drinking water (CaLP). The results showed body @entity0 in all FW groups were more than 25% that was significantly higher than FF group (p  <  0.05). The relative organ weights of hens in FW groups were lower than FF group; especially, it was significant for liver and ovary (p  <  0.05). No significant difference was observed between all groups for tibia ash. The highest H/L ratio was related to FW group and offering @entity4 and @entity3 numerically and probiotic alone significantly resulted in decrease of this ratio (p  <  0.05). The results also showed no significant difference for antibody production against SRBC among experimental groups. The highest coliform bacteria numeration observed in FW group and @entity3 could significantly reduce this population (p  <  0.05). Lactic acid bacteria (LAB) numeration demonstrated a significant difference among treatments, so that FF hens had higher LAB than others (p  <  0.05). In addition, FW moulted hens had significantly lower LAB compared to other moulted hens (p  <  0.05), except for @entity4 group. In conclusion, probiotic and @entity3 was effective in maintaining caecal microbiota balance and improving immunity in hens exposed to moulting.

title: Effect of XXXX with and without probiotic, @entity3 , or both on organ and body weights, immune response and caecal microbiota in moulted laying hens.

answer: @entity1


abstract: UNASSIGNED: A total of 72 laying hens were used to investigate the effect of probiotic and @entity3 on body @entity0 , tibia ash, antibody production against @entity2 red blood cell (SRBC), heterophile-to-lymphocyte (H/L) ratio and gut microbiota in a common moulting method for 14 d. Hens were randomly allocated to 6 experimental groups consisting of (i) full feed (FF), (ii) feed withdrawal (FW), (iii) FW with @entity1 ( @entity4 ), (iv) FW with @entity4 and offering 7  g/lit @entity3 in drinking water (CaL), (v) FW with @entity4 and offering 1  g/lit probiotic in drinking water (CaP), and (vi) FW with @entity4 and offering a mixture of @entity3 and probiotic in drinking water (CaLP). The results showed body @entity0 in all FW groups were more than 25% that was significantly higher than FF group (p  <  0.05). The relative organ weights of hens in FW groups were lower than FF group; especially, it was significant for liver and ovary (p  <  0.05). No significant difference was observed between all groups for tibia ash. The highest H/L ratio was related to FW group and offering @entity4 and @entity3 numerically and probiotic alone significantly resulted in decrease of this ratio (p  <  0.05). The results also showed no significant difference for antibody production against SRBC among experimental groups. The highest coliform bacteria numeration observed in FW group and @entity3 could significantly reduce this population (p  <  0.05). Lactic acid bacteria (LAB) numeration demonstrated a significant difference among treatments, so that FF hens had higher LAB than others (p  <  0.05). In addition, FW moulted hens had significantly lower LAB compared to other moulted hens (p  <  0.05), except for @entity4 group. In conclusion, probiotic and @entity3 was effective in maintaining caecal microbiota balance and improving immunity in hens exposed to moulting.

title: Effect of @entity1 with and without probiotic, XXXX , or both on organ and body weights, immune response and caecal microbiota in moulted laying hens.

answer: @entity3


abstract: PURPOSE: @entity4 associated @entity1 (CDAD) is the most common cause of health-care-associated infectious @entity1 . In the context of the German health-care system, direct and indirect costs of an initial episode of CDAD and of CDAD recurrence are currently unknown. METHODS: We defined CDAD as presence of @entity1 (>= 3 unformed stools/day) in association with detection of @entity4 toxin in an unformed faecal sample. @entity0 treated with @entity2 (PO or IV) and/or @entity3 (PO) were included. Comprehensive data of @entity0 were retrospectively documented into a database using the technology of the Cologne Cohort of Neutropenic @entity0 (CoCoNut). @entity0 with CDAD were matched to control @entity0 in a 1:1 ratio. Analysis was split in three groups: incidence group (CDAD @entity0 without recurrence), recurrence group (CDAD @entity0 with >= 1 recurrence) and control group (matched non-CDAD @entity0 ). RESULTS: Between 02/2010 and 12/2011, 150 @entity0 with CDAD (114 @entity0 in the incidence and 36 (24  %) in the recurrence group) and 150 controls were analysed. Mean length of stay was: 32 (95  %CI: 30-37), 94 (95  %CI: 76-112) and 24  days (95  %CI: 22-27; P  =  <0.001), resulting in mean overall direct treatment costs per @entity0 of    18,460 (95  %CI:    14,660-   22,270),    73,900 (95  %CI:    50,340-   97,460) and    14,530 (95  %CI:    11,730-   17,330; P  =  <0.001). In the incidence and recurrence group, the mean cumulative number of antibiotic CDAD treatment days was 11 (95  %CI: 10-12) and 36 (95  %CI: 27-45; P  =  <0.001). CONCLUSIONS: Especially CDAD recurrence was associated with excessive costs, which were mostly attributable to a significantly longer overall length of stay. Innovative treatment strategies are warranted to reduce treatment costs and prevent recurrence of CDAD.

title: Economic burden of @entity4 associated XXXX : a cost-of-illness study from a German tertiary care hospital.

answer: @entity1


abstract: PURPOSE: @entity4 associated @entity1 (CDAD) is the most common cause of health-care-associated infectious @entity1 . In the context of the German health-care system, direct and indirect costs of an initial episode of CDAD and of CDAD recurrence are currently unknown. METHODS: We defined CDAD as presence of @entity1 (>= 3 unformed stools/day) in association with detection of @entity4 toxin in an unformed faecal sample. @entity0 treated with @entity2 (PO or IV) and/or @entity3 (PO) were included. Comprehensive data of @entity0 were retrospectively documented into a database using the technology of the Cologne Cohort of Neutropenic @entity0 (CoCoNut). @entity0 with CDAD were matched to control @entity0 in a 1:1 ratio. Analysis was split in three groups: incidence group (CDAD @entity0 without recurrence), recurrence group (CDAD @entity0 with >= 1 recurrence) and control group (matched non-CDAD @entity0 ). RESULTS: Between 02/2010 and 12/2011, 150 @entity0 with CDAD (114 @entity0 in the incidence and 36 (24  %) in the recurrence group) and 150 controls were analysed. Mean length of stay was: 32 (95  %CI: 30-37), 94 (95  %CI: 76-112) and 24  days (95  %CI: 22-27; P  =  <0.001), resulting in mean overall direct treatment costs per @entity0 of    18,460 (95  %CI:    14,660-   22,270),    73,900 (95  %CI:    50,340-   97,460) and    14,530 (95  %CI:    11,730-   17,330; P  =  <0.001). In the incidence and recurrence group, the mean cumulative number of antibiotic CDAD treatment days was 11 (95  %CI: 10-12) and 36 (95  %CI: 27-45; P  =  <0.001). CONCLUSIONS: Especially CDAD recurrence was associated with excessive costs, which were mostly attributable to a significantly longer overall length of stay. Innovative treatment strategies are warranted to reduce treatment costs and prevent recurrence of CDAD.

title: Economic burden of XXXX associated @entity1 : a cost-of-illness study from a German tertiary care hospital.

answer: @entity4


abstract: INTRODUCTION: With a focus on raising the quality of @entity2 care through creation of educational programs, SAGES formed the Hernia Task Force (HTF). This study used needs assessment survey to target opportunities for improving surgical training and thus @entity0 outcomes and experience. METHODS: This qualitative study included structured interviews and online surveys of key stakeholders: HTF members, surgeons, nurses, @entity0 , hospital administrators, healthcare payers and medical suppliers. Questions included perceptions of recurrence and complication rates, their etiologies, perceived @entity1 care and the most effective and training modalities. RESULTS: A total of 841 @entity0 included 665 surgeons, 66 @entity0 care team members, 12 hospital administrators and 14 medical supply providers. Assessment of technical approach revealed that nearly 26  % of surgeons apply the same, limited range of techniques to all @entity0 without evaluation of @entity0 -specific factors. The majority (71  %) of surgeon respondents related @entity2 recurrence rates nearing 25  % or more. HTF members implicated surgeon factors (deficits in knowledge/technique, etc.) as primary determinants of recurrences, whereas nurses, medical supply providers and hospital administrators implicated @entity0 health factors. Surgeons preferred attending conferences (82  %), reading periodicals/publications (71  %), watching videos (59  %) and communicating with peers (57  %) for learning and skill improvement. Topics of the greatest interest were advanced techniques for @entity2 repairs (71  %), preoperative and intraoperative decision making (56  %) and @entity0 outcomes (64  %). Eighty-six percent of nurses felt that there was room for improvement in @entity2 @entity0 safety and teamwork in the OR. Only 24  % believed that the @entity0 had adequate preoperative education. CONCLUSIONS: Major reported deficits in @entity2 care include: lack of standardization in training and care, "one size fits all" technical approach and inadequate @entity0 follow-up/outcome measures. There is a need for a comprehensive, flexible and tailored educational program to equip surgeons and their teams to raise the quality of @entity2 care and bring greater value to their @entity0 .

title: Raising the quality of XXXX care: Is there a need?

answer: @entity2