abstract: OBJECTIVE: To validate the efficacy and safety of laparoscopic total gastrectomy (LTG) for advanced @entity2 (AGC). BACKGROUND: Laparoscopic distal gastrectomy (LDG) in the treatment of @entity0 with local AGC is becoming increasingly popular, and there have been several multicenter randomized controlled trials focused on this treatment. However, few reports on the procedure of LTG for AGC exist. METHODS: The data of 976 @entity0 who underwent LTG for AGC were retrieved from a prospectively constructed database of 2170 @entity0 who underwent laparoscopic gastrectomy between 2007 and 2013. Surgical outcomes of LTG were investigated and compared with those of @entity0 who underwent LDG. RESULTS: LTG was associated with significantly longer operation time, number of dissected lymph nodes, and time of resume soft diet compared with the LDG group. According to Clavien-Dindo classification, the morbidity and mortality rates of the LTG group were comparable to those of the LDG group. Multivariate analyses revealed that elderly @entity0 , more comorbidities, and longer operation time were the significant independent risk factors for @entity1 . The difference in overall survival rates between the two groups was statistically significant. However, a comparative analysis of overall survival showed no statistical significance for any of the stages of cancer between the LTG and LDG groups. CONCLUSIONS: The study findings suggest that LTG is an oncologically safe procedure for AGC yields comparable surgical outcomes. A well-designed phase III trial can be carried out to provide valuable evidence for the oncologic safety of LTG for the treatment of AGC.

title: Evaluation of laparoscopic total gastrectomy for advanced XXXX : results of a comparison with laparoscopic distal gastrectomy.

answer: @entity2


abstract: OBJECTIVE: To evaluate the association between subclinical @entity3 and @entity1 using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). DESIGN: Cross-sectional study. @entity0 : The study included 12  437 @entity0 from the ELSA-Brasil with normal thyroid function (92  8%), 193 (1  4%) with @entity5 and 784 (5  8%) with @entity4 , totalling 13  414 @entity0 (50  6% of @entity0 ). MEASUREMENTS: The mental health diagnoses of @entity0 were assessed by trained raters using the Clinical Interview Schedule - Revised (CIS-R) and grouped according to the International Classification of Diseases 10 (ICD-10). @entity3 was assessed using TSH and FT4 as well as routine use of thyroid hormones or antithyroid medications. Logistic models were presented using @entity1 as the dependent variable and subclinical @entity3 as the independent variable. All logistic models were corrected for multiple comparisons using Bonferroni correction. RESULTS: After multivariate adjustment for possible confounders, we found a direct association between @entity5 and @entity6 odds ratio [OR], 2  55; 95% confidence Interval (95% CI), 1  09-5  94; and an inverse association between @entity4 and generalized @entity2 (OR, 0  75; 95% CI, 0  59-0  96). However, both lost significance after correction for multiple comparisons. CONCLUSION: @entity5 was positively associated with @entity6 and negatively associated with @entity2 , although not significant after adjustment for multiple comparisons.

title: Subclinical XXXX and @entity1 : cross-sectional results from the Brazilian Study of Adult Health (ELSA-Brasil).

answer: @entity3


abstract: OBJECTIVE: To evaluate the association between subclinical @entity3 and @entity1 using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). DESIGN: Cross-sectional study. @entity0 : The study included 12  437 @entity0 from the ELSA-Brasil with normal thyroid function (92  8%), 193 (1  4%) with @entity5 and 784 (5  8%) with @entity4 , totalling 13  414 @entity0 (50  6% of @entity0 ). MEASUREMENTS: The mental health diagnoses of @entity0 were assessed by trained raters using the Clinical Interview Schedule - Revised (CIS-R) and grouped according to the International Classification of Diseases 10 (ICD-10). @entity3 was assessed using TSH and FT4 as well as routine use of thyroid hormones or antithyroid medications. Logistic models were presented using @entity1 as the dependent variable and subclinical @entity3 as the independent variable. All logistic models were corrected for multiple comparisons using Bonferroni correction. RESULTS: After multivariate adjustment for possible confounders, we found a direct association between @entity5 and @entity6 odds ratio [OR], 2  55; 95% confidence Interval (95% CI), 1  09-5  94; and an inverse association between @entity4 and generalized @entity2 (OR, 0  75; 95% CI, 0  59-0  96). However, both lost significance after correction for multiple comparisons. CONCLUSION: @entity5 was positively associated with @entity6 and negatively associated with @entity2 , although not significant after adjustment for multiple comparisons.

title: Subclinical @entity3 and XXXX : cross-sectional results from the Brazilian Study of Adult Health (ELSA-Brasil).

answer: @entity1


abstract: BACKGROUND: An abnormal ankle-brachial index has been associated with @entity2 and @entity4 , but little is known about its relationship with silent @entity7 . AIM: To assess the value of ankle-brachial index as a predictor of silent small vessel disease in an Ecuadorian geriatric population. METHODS: @entity2 -free Atahualpa residents aged >= 60 years were identified during a door-to-door survey. Ankle-brachial index determinations and brain magnetic resonance imaging were performed in consented @entity0 . Ankle-brachial index  <=0  9 and >= 1  4 were proxies of @entity6 and noncompressible arteries, respectively. Using logistic regression models adjusted for age, gender, and @entity3 status, we evaluated the association between abnormal ankle-brachial index with silent @entity5 , @entity1 , and cerebral microbleeds. RESULTS: Mean age of the 224 @entity0 was 70        8 years, 60% were @entity0 , and 80% had poor @entity3 status. Ankle-brachial index was  <=0  90 in 37 @entity0 and >= 1  4 in 17. Magnetic resonance imaging showed @entity5 in 27 cases, moderate-to-severe @entity1 in 47, and cerebral microbleeds in 26. Adjusted models showed association of @entity5 with ankle-brachial index    <=   0  90 (OR: 3  72, 95% CI: 1  35-10  27, P   =   0  01) and with ankle-brachial index   >=    1  4 (OR: 3  85, 95% CI: 1  06-14  03, P   =   0  04). @entity1 were associated with ankle-brachial index    <=   0  90 (P   =   0  03) and ankle-brachial index   >=    1  4 (P   =   0  02) in univariate analyses. There was no association between ankle-brachial index groups and cerebral microbleeds. CONCLUSIONS: In this population-based study conducted in rural Ecuador, apparently healthy individuals aged >= 60 years with ankle-brachial index values  <=0  90 and >= 1  4 are almost four times more likely to have a silent @entity5 . Ankle-brachial index screening might allow recognition of asymptomatic @entity0 who need further investigation and preventive therapy.

title: The association of ankle-brachial index with silent XXXX : results of the Atahualpa Project.

answer: @entity7


abstract: UNASSIGNED: Airway smooth muscle (ASM) is the effector cell in the bronchoconstrictory pathway. It is believed that the bronchoconstriction present in @entity2 is associated with changes in the airway milieu that affect ASM excitation-contraction coupling and @entity1 -handling. Asthmatics also react differently to ventilatory mechanical strain. Deep inspiration (DI), which produces bronchodilation in healthy individuals, is less effective in @entity3 , and even enhances bronchoconstriction in moderate to severely affected @entity0 . Our laboratory has previously studied the mechanotransductory pathway of airway stretch-activated contractions (Rstretch) leading to DI-induced bronchoconstriction. We demonstrated the ability of agonists acting through @entity4 (TxA2) receptors to amplify airway Rstretch responses. Despite the involvement of excitatory @entity5 in bronchoconstriction, clinical trials on treatments targeting TxA2-synthase inhibition and TP-receptor antagonism have produced mixed results. Studies in Western populations produced mostly negative results, whereas studies performed in Asian populations showed mostly positive outcomes. In this review, we discuss the role of TxA2-synthase inhibition and TP-receptor antagonism in the treatment of @entity3 . We present information regarding variations in study designs and the possible role of TP-receptor gene polymorphisms in previous study outcome discrepancies. Perhaps future studies should focus on @entity3 @entity0 with DI-induced bronchoconstriction in particular, planting the seed for the individualized treatments for @entity3 .

title: Revisiting the usefulness of XXXX modulation in the treatment of bronchoconstriction in @entity2 .

answer: @entity4


abstract: UNASSIGNED: Airway smooth muscle (ASM) is the effector cell in the bronchoconstrictory pathway. It is believed that the bronchoconstriction present in @entity2 is associated with changes in the airway milieu that affect ASM excitation-contraction coupling and @entity1 -handling. Asthmatics also react differently to ventilatory mechanical strain. Deep inspiration (DI), which produces bronchodilation in healthy individuals, is less effective in @entity3 , and even enhances bronchoconstriction in moderate to severely affected @entity0 . Our laboratory has previously studied the mechanotransductory pathway of airway stretch-activated contractions (Rstretch) leading to DI-induced bronchoconstriction. We demonstrated the ability of agonists acting through @entity4 (TxA2) receptors to amplify airway Rstretch responses. Despite the involvement of excitatory @entity5 in bronchoconstriction, clinical trials on treatments targeting TxA2-synthase inhibition and TP-receptor antagonism have produced mixed results. Studies in Western populations produced mostly negative results, whereas studies performed in Asian populations showed mostly positive outcomes. In this review, we discuss the role of TxA2-synthase inhibition and TP-receptor antagonism in the treatment of @entity3 . We present information regarding variations in study designs and the possible role of TP-receptor gene polymorphisms in previous study outcome discrepancies. Perhaps future studies should focus on @entity3 @entity0 with DI-induced bronchoconstriction in particular, planting the seed for the individualized treatments for @entity3 .

title: Revisiting the usefulness of @entity4 modulation in the treatment of bronchoconstriction in XXXX .

answer: @entity2


abstract: Dyspnea represents 3-4 % of consultations at primary care medicine (general medicine, emergency medicine) and is found in 14 % of the interviewed general population. It is defined as an abnormal and uncomfortable @entity6 and can be classified according to the mode of appearance, the @entity6 pattern or the rhythm. Different classifications are used to specify the severity of the situation: visual analog scale, functional classification of the New York Heart Association, @entity6 modified scale from the Medical Research Council, ... Rare among young @entity0 , @entity6 often hides @entity3 ; more prevalent among seniors, it is often secondary to chronic lung or @entity2 . The rational approach is the same in general medicine and in the emergency room. The management starts with an assessment of the severity of the @entity0 's clinical situation, via the early warning score. The critical @entity0 requires to be managed according to the progressive and cyclical ABCDE approach. For non-critical @entity0 , a traditional approach and a reasoned method are needed. In @entity0 suffering from @entity4 ( @entity4 ), the use of the Anthonissen criteria allows to orient toward a pulmonary superinfection or another cause of worsening @entity6 (cardiac, ...). In case of suspected @entity5 , the Geneva score and the modified Wells score help to separate low, intermediate or high probability cases of @entity5 . D-dimers have a very good negative predictive value in the low and middle risk group and pulmonary CT angiography applies only to a smaller group of dyspnoeic @entity0 with a high probability of @entity5 . Echocardiography has a prominent role to assess the LV systolic function, the search for @entity1 , the vascular filling state, etc. We speak of psychogenic @entity6 after having excluded the potentially serious pathologies.

title: [Rational approach and management of the dyspnoeic XXXX in general medical practice].

answer: @entity0


abstract: UNASSIGNED: In @entity1 , an alkaline/neutral invertase (A/N- @entity2 ) is responsible for sucrose catabolism in latex (essentially the cytoplasm of rubber-producing laticifers, the source of natural rubber) and implicated in rubber yield. However, neither the gene encoding this enzyme nor its molecular and biochemical properties have been well documented. Three Hevea A/N- @entity2 genes, namely HbNIN1, 2 and 3, were first cloned and characterized in planta and in @entity0 . Cellular localizations of HbNIN2 mRNA and protein were probed. From latex, active A/N- @entity2 proteins were purified, identified, and explored for enzymatic properties. HbNIN2 was identified as the major A/N- @entity2 gene functioning in latex based on its functionality in @entity0 , its latex-predominant expression, the conspicuous localization of its mRNA and protein in the laticifers, and its expressional correlation with rubber yield. An active A/N- @entity2 protein was partially purified from latex, and determined as HbNIN2. The enhancement of HbNIN2 enzymatic activity by pyridoxal is peculiar to A/N-Invs in other plants. We conclude that HbNIN2, a cytosolic A/N- @entity2 , is responsible for sucrose catabolism in rubber laticifers. The results contribute to the studies of sucrose catabolism in plants as a whole and natural rubber synthesis in particular.

title: HbNIN2, a cytosolic alkaline/neutral-invertase, is responsible for sucrose catabolism in rubber-producing laticifers of XXXX ( @entity1 ).

answer: @entity1


abstract: UNASSIGNED: In @entity1 , an alkaline/neutral invertase (A/N- @entity2 ) is responsible for sucrose catabolism in latex (essentially the cytoplasm of rubber-producing laticifers, the source of natural rubber) and implicated in rubber yield. However, neither the gene encoding this enzyme nor its molecular and biochemical properties have been well documented. Three Hevea A/N- @entity2 genes, namely HbNIN1, 2 and 3, were first cloned and characterized in planta and in @entity0 . Cellular localizations of HbNIN2 mRNA and protein were probed. From latex, active A/N- @entity2 proteins were purified, identified, and explored for enzymatic properties. HbNIN2 was identified as the major A/N- @entity2 gene functioning in latex based on its functionality in @entity0 , its latex-predominant expression, the conspicuous localization of its mRNA and protein in the laticifers, and its expressional correlation with rubber yield. An active A/N- @entity2 protein was partially purified from latex, and determined as HbNIN2. The enhancement of HbNIN2 enzymatic activity by pyridoxal is peculiar to A/N-Invs in other plants. We conclude that HbNIN2, a cytosolic A/N- @entity2 , is responsible for sucrose catabolism in rubber laticifers. The results contribute to the studies of sucrose catabolism in plants as a whole and natural rubber synthesis in particular.

title: HbNIN2, a cytosolic alkaline/neutral-invertase, is responsible for sucrose catabolism in rubber-producing laticifers of @entity1 ( XXXX ).

answer: @entity1


abstract: OBJECTIVE: To measure the changes of mean platelet volume ( @entity8 ) after using four antiplatelet drugs in acute non-cardioembolic @entity4 @entity0 and assess the association of antiplatelets and @entity8 and @entity1 outcome. MATERIAL AND METHOD: @entity4 survivors with National Institute of Health @entity1 Scale (NIHSS) 8 were randomly allocated intofour groups, receiving @entity3 , @entity5 , combined @entity3 and @entity7 , and @entity6 . The change of @entity8 NIHSS, and modified Rankin Scale ( @entity9 ) were recorded at baseline and week 4 in all studied groups. @entity8 was measured using the standard automated blood test for complete blood count. RESULTS: Twenty-one subjects were included in this study. They comprised of five cases in each antiplatelet group, except for @entity3 , which had six subjects. Male was 57%, and @entity2 was the most common risk factor (61.9%). Most of @entity0 (76%) had small vessel disease. At 4-week, MPVwas reduced and NIHSS, @entity9 were improved in every studied group. @entity5 sign ficantly reduced NIHSS score (p = 0.003), and it produced the greatest reduction in @entity8 compared to others. CONCLUSION: Every type of antiplatelets included in this study reduced @entity8 NIHSS, and @entity9 in acute non- @entity1 @entity0 . @entity5 improved NIHSS the most.

title: The Changes in Mean Platelet Volume after Using of Antiplatelet Drugs in Acute XXXX : A Randomized Controlled Trial.

answer: @entity4


abstract: OBJECTIVE: To examine the characteristics of the plantar pressure distribution patterns during mid-stance phase of the gait cycle in subjects with chronic non-specific @entity1 and asymptomatic subjects. MATERIAL AND METHOD: Twenty-three males and 17 females with chronic non-specific @entity1 and age- and gender-matched asymptomatic subjects walked barefoot along a gait mat at comfortable speedfor three trials. The left and right plantar pressure distributions were recorded during mid-stance phase and divided into 12 areas. Descriptive statistics including mean and standard deviation of demographic data and plantar pressure were calculated, and plantar pressure distribution patterns were described. RESULTS: Mean and standard deviation of @entity0 rating scale of chronic non-specific @entity1 group were 4.04  1.58. The average mean peak pressure of both chronic non-specific @entity1 and asymptomatic subjects located at the fifth area (lateral aspect offorefoot) in both feet. However the modes of the peak pressure of subjects with chronic non-specific @entity1 were in the different areas in the left and right feet. The distribution patterns of the average mean peak pressure were not the same in chronic non-specific @entity1 and asymptomatic subjects. This altered foot contact in the subjects with chronic non-specific @entity1 may be used to avoid @entity0 or to compensate for limited mobility of the lower limbs at pre-swing phase. CONCLUSION: At mid-stance phase of walking, the pressures on the plantar surface were unequally distributed in subjects with chronic non-specific @entity1 .

title: Plantar Pressure Distribution Pattern during Mid-Stance Phase of the Gait in Patients with Chronic Non-Specific Low Back XXXX .

answer: @entity0


abstract: OBJECTIVE: To evaluate growth rate of aortic diameter true lumen, and false lumen in post endovascular aortic repair of @entity1 . MATERIAL AND METHOD: Between January 2005 and September 2010, 48 consecutive @entity0 with @entity1 were followed with computed tomographic angiography (CTA), including 18 post-surgical repaired type A @entity0 and 30 @entity2 (14 conservative treatment and 16 post stent-grafting therapy). CTA were performed with a mean of 5.2 scans per @entity0 , and a meanfollow-up of 37.08 months. The diameter ofthe aorta, true lumen, andfalse lumen were measured by axial scan images and multi-planar reformatting (MPR). RESULTS: In medically managed @entity0 with @entity2 @entity1 , the aortic diameter increased over time at mean rate 1.49 mm/year at proximal descending aorta with greater increased in size ofthe false lumen diameters than the true lumen diameter. In post-surgical repaired type A and post stent-grafting therapy @entity2 @entity1 , aortic diameter did not change over time. In addition, 12 of 16 @entity0 (75%) @entity0 with post stent-grafting therapy @entity2 dissection hadpartial thrombosed in false lumen and 4 of 16 @entity0 (25%) had complete resolution offalse lumen. CONCLUSION: In post-surgical repaired type A and post stent-grafting therapy @entity2 @entity1 , aortic diameter did not change over time. @entity1 with medical treatment had minimal increased in aortic diameter over time. The results suggested that uncomplicated @entity2 @entity1 requires on-going medical treatment.

title: Growth Rate of Aortic Diameter in Post Treatment of XXXX .

answer: @entity1


abstract: BACKGROUND _ AIMS: @entity0 with @entity2 can be identified based on the detection of serum antibodies to deamidated gliadin peptides (DGPs). Recombinant human monoclonal antibodies (hmAb) against gliadin are produced by cloning antibody genes from single IgA-producing plasma cells isolated from lesions of @entity0 with @entity2 . We developed an assay to identify @entity0 with @entity2 based on the ability of antibodies from their serum to inhibit the binding of a gliadin-specific hmAb (1002-1E03) to a specific peptide antigen (inhibition assay). METHODS: We selected 2 peptides (a 34-mer and a 26-mer) found in   -gliadins and low-molecular-weight glutenins that had been identified as specific targets of the hmAb 1002-1E03 from a digest of gliadin treated by @entity3 . These peptides contained repeat sequence motifs; their interaction with hmAb 1002-1E03 was assessed in an amplified luminescent proximity homogeneous inhibition assay. We also tested peptides we created that included 3 repeated sequence motifs. Serum samples from untreated @entity0 diagnosed with @entity2 (n  = 106) and 2 control groups (198 blood donors, 151 @entity0 with @entity1 ) were analyzed using the assay, as well as in conventional commercial assays that measure IgA against @entity3 ( @entity3 ) or IgG against DGP. RESULTS: In our inhibition assays, the 34-mer peptide showed the best results, and identified @entity0 with @entity2 with 86.8% sensitivity and 98.6% specificity. Its diagnostic accuracy was comparable with that of commercial anti-DGP IgG (sensitivity, 87.9%; specificity, 98.0) and anti- @entity3 IgA (sensitivity, 81.1%; specificity, 98.9) assays, and it detected most of the patients with anti- @entity3 IgA-negative @entity2 without a significant decrease in specificity. Combined use of the anti-  34 and the anti- @entity3 assays produced specificity and sensitivity values of 95.3% and 98.0%, respectively. CONCLUSIONS: We developed an antigliadin inhibition assay that identifies @entity0 with @entity2 with high levels of specificity and sensitivity. It may prove useful as an adjunct to the current assay for anti- @entity3 IgA.

title: Serologic Assay for Diagnosis of XXXX Based on a Patient-Derived Monoclonal Antigliadin Antibody.

answer: @entity2


abstract: @entity2 is the most malignant and most common primary @entity3 and is treated with resection followed by post-operative radiotherapy and chemotherapy. However, a significant amount of @entity0 are older than 80 years, and such an approach may not be appropriate. Data on @entity0 aged 80 or older with @entity2 from two hospitals was collected using the CNS @entity1 Database on the Australian Comprehensive Cancer Outcomes and Research Database (ACCORD) system operated by BioGrid. Between 2008 and July 2011, 40 @entity0 aged 80 years or older were diagnosed with @entity2 . The median ECOG PS was 2 and the ASA score was 3. All 40 @entity0 underwent surgery and 33% had a gross total resection. Only six @entity0 (15%) had either post-operative radiotherapy or chemotherapy. The overall median survival was 4 months (range 0-18 months) and 28% of @entity0 lived between 6 and 24 months. This is the largest reported cohort of very elderly @entity0 with @entity2 . @entity0 tolerated surgery but few went on to receive post-operative radiotherapy or chemotherapy. This @entity0 population requires special attention and in particular would benefit from participation in suitable clinical trials to determine the best care regime.

title: XXXX multiforme in the very elderly.

answer: @entity2


abstract: OBJECTIVE: To investigate the effects of chemotherapy and cranial irradiation on normal brain tissue using in vivo neuroimaging in @entity0 with @entity2 . METHODS: We used longitudinal MRI to monitor structural brain changes during standard treatment in @entity0 newly diagnosed with @entity2 . We assessed volumetric and diffusion tensor imaging measures in 14 @entity0 receiving 6 weeks of chemoradiation, followed by up to 6 months of @entity3 chemotherapy alone. We examined changes in whole brain, gray matter (GM), white matter (WM), anterior lateral ventricle, and hippocampal volumes. Normal-appearing GM, WM, and hippocampal analyses were conducted within the hemisphere of lowest/ @entity1 burden. We examined diffusion tensor imaging measures within the subventricular zone. RESULTS: Whole brain (F = 2.41; p = 0.016) and GM (F = 2.13; p = 0.036) volume decreased during treatment, without significant WM volume change. Anterior lateral ventricle volume increased significantly (F = 65.51; p < 0.001). In @entity0 analyzed beyond 23 weeks, mean ventricular volume increased by 42.2% (SE: 8.8%; t = 4.94; p < 0.005). Apparent diffusion coefficient increased within the subventricular zone (F = 7.028; p < 0.001). No significant changes were identified in hippocampal volume. CONCLUSIONS: We present evidence of significant and progressive treatment-associated structural brain changes in @entity0 with @entity2 treated with standard chemoradiation. Future studies using longitudinal neuropsychological evaluation are needed to characterize the functional consequences of these structural changes.

title: Standard chemoradiation for XXXX results in progressive brain volume loss.

answer: @entity2


abstract: PURPOSE: To review the clinical outcomes of extended-field radiation therapy (EFRT) and to analyze prognostic factors significant for survival in @entity0 receiving EFRT for uterine @entity6 with para-aortic node (PAN) @entity1 . @entity0 AND METHODS: We retrospectively reviewed 90 @entity0 with @entity2 and PAN @entity1 between 1987 and 2012. Median age was 50 (range, 24-77). @entity0 received median 70.2 Gy (range, 56-93) to point A and median 50.4 Gy (range, 45-60.4) to PAN over median 69 elapsed days (range, 43-182). Forty-six @entity0 (51.1%) received concurrent chemotherapy. Survival was calculated using the Kaplan-Meier method. We analyzed prognostic factors for @entity5 ( @entity5 ) and progression-free survival (PFS) using a Cox regression method. RESULTS: The median follow-up period for surviving @entity0 was 55 months (range, 3-252). Seventy @entity0 (77.8%) had complete remission. Forty-six @entity0 experienced treatment failure as follows: 11 @entity0 (12.2%) as local recurrence, 19 (21%) as regional recurrence and 33 (36.7%) as distant @entity1 . The 5-yr @entity5 and PFS were 62.6% and 43.9%, respectively. Treatment response was the only statistically independent prognostic factors for @entity5 (p= 0.04) and PFS (p< 0.001) on multivariate analysis. Grade 3 or 4 hematologic @entity4 were observed in about 10% of @entity0 . CONCLUSIONS: Our institutional experiences showed that EFRT was an effective treatment for @entity2 @entity0 with PAN @entity1 . The addition of chemotherapy to EFRT seems to have uncertain survival benefit with higher hematologic @entity3 .

title: Treatment outcomes of extended-field radiation therapy and the effect of concurrent @entity2 with para-aortic lymph node XXXX .

answer: @entity1


abstract: PURPOSE: To review the clinical outcomes of extended-field radiation therapy (EFRT) and to analyze prognostic factors significant for survival in @entity0 receiving EFRT for uterine @entity6 with para-aortic node (PAN) @entity1 . @entity0 AND METHODS: We retrospectively reviewed 90 @entity0 with @entity2 and PAN @entity1 between 1987 and 2012. Median age was 50 (range, 24-77). @entity0 received median 70.2 Gy (range, 56-93) to point A and median 50.4 Gy (range, 45-60.4) to PAN over median 69 elapsed days (range, 43-182). Forty-six @entity0 (51.1%) received concurrent chemotherapy. Survival was calculated using the Kaplan-Meier method. We analyzed prognostic factors for @entity5 ( @entity5 ) and progression-free survival (PFS) using a Cox regression method. RESULTS: The median follow-up period for surviving @entity0 was 55 months (range, 3-252). Seventy @entity0 (77.8%) had complete remission. Forty-six @entity0 experienced treatment failure as follows: 11 @entity0 (12.2%) as local recurrence, 19 (21%) as regional recurrence and 33 (36.7%) as distant @entity1 . The 5-yr @entity5 and PFS were 62.6% and 43.9%, respectively. Treatment response was the only statistically independent prognostic factors for @entity5 (p= 0.04) and PFS (p< 0.001) on multivariate analysis. Grade 3 or 4 hematologic @entity4 were observed in about 10% of @entity0 . CONCLUSIONS: Our institutional experiences showed that EFRT was an effective treatment for @entity2 @entity0 with PAN @entity1 . The addition of chemotherapy to EFRT seems to have uncertain survival benefit with higher hematologic @entity3 .

title: Treatment outcomes of extended-field radiation therapy and the effect of concurrent XXXX with para-aortic lymph node @entity1 .

answer: @entity2


abstract: AIMS: Vulnerable plaques are characterized by a high macrophage content. We investigated the optical coherence tomography (OCT) capability of identifying coronary plaque macrophage presence using tissue property indexes. METHODS AND RESULTS: Fifteen epicardial coronary arteries were imaged by OCT and subsequently analysed by histology. Correlating OCT-histological sections were identified and @entity0 ( @entity0 ) were selected on both @entity2 and normal appearing vessel tracts. OCT-derived tissue property indexes named @entity3 ( @entity3 ), signal attenuation, and granulometry index were applied on @entity0 to identify inflamed @entity0 defined as a macrophage percentage >10 by histology. Forty-three paired samples (OCT frame and histology section) were considered suitable as @entity0 for analysis. Eleven out of 43 @entity0 were considered inflamed and the remaining 32 @entity0 were non-inflamed on the basis of histological count of macrophage percentage. All OCT-derived tissue property indexes were positively correlated with macrophage percentage (P = 0.0001 for all). Receiver operating characteristic curve analysis showed that @entity3 , granulometry index, and signal attenuation had a significant area under the curve (area = 0.906, 0.804, and 0.793, respectively). A two-step algorithm requiring to first apply @entity3 with a cut-off value of 0.0570 followed by granulometry index was able to identify an inflamed ROI with a sensitivity of 100% and a specificity of 96.8%. CONCLUSION: OCT was able to identify and quantify macrophage presence in coronary artery specimens using tissue property indexes. @entity3 and granulometry index showed the highest accuracy in identifying a significant @entity1 , especially if used together in a two-step algorithm.

title: Identification and quantification of macrophage presence in coronary XXXX by optical coherence tomography.

answer: @entity2


abstract: PURPOSE: This study aims to represent the epidemiologies, findings, treatments, use of resources, outcomes and protective-eyewear-use recommendations in sports-related @entity2 by sport type. METHODS: The study population is comprised of all new @entity2 @entity0 in 1  year in Helsinki University Eye Hospital. Data were collected from @entity0 questionnaires and hospital records. The follow-up period was 3  months. RESULTS: 149/1151 (12.9%) of @entity2 were sports-related. Thirty two percent were related to floorball (type of hockey played on a mat with a stick and a ball); football, tennis and ice hockey were the next most common @entity2 -causing sports. Relatively, the most dangerous sports were rink bandy, (bandy played on ice hockey rink with a stick and a ball) (0.50 injuries in 12  months/1000 @entity0 , CI 0.10-1.46), floorball (0.47, CI 0.34-0.62) and tennis (0.47, CI 0.26-0.77). Contusion was the primary diagnosis in 77% of cases; 41% of @entity1 @entity0 had severe, mainly retinal findings. The number of outpatient visits was 459; inpatient days 25 and major surgeries 31. One hundred and eight @entity0 were estimated to need life-long follow-up. Seventeen @entity0 had a permanent functional impairment, 4 in ice hockey, 3 in floorball, 2 each in tennis and badminton. CONCLUSION: Compared to a previous study, ice @entity2 are increasing and relatively severe, and a third of these injuries occurred despite visor use. @entity2 incidence has significantly declined, mainly due to recently enforced mandatory protective eyewear for younger age groups. Based on these findings, we recommend, in floorball, that protective eyewear should be mandatory in all age groups. Universally in ice hockey, the proper use of a visor should be emphasised.

title: Sports-related XXXX : the current picture.

answer: @entity2


abstract: @entity1 is a main cause of @entity3 . Epithelial-to-mesenchymal transition (EMT) markers play a role in renal @entity2 . @entity6 ( @entity6 ) has been shown to initiate and complete the whole EMT process. It is now well accepted that loss of @entity8 , EMT marker @entity5 , and @entity9 ( @entity9 ) expression are key events in the EMT process. We found that by stimulating @entity0 renal proximal tubular epithelial ( @entity0 ) cells with @entity6 , the expression of @entity8 was down regulated and the expression of @entity5 and @entity9 were up regulated in a dose dependent manner. In our present study we also found that integrin @entity4 ( @entity7 -y) play roles in EMT process, with @entity6 stimulation increasing integrin b4 expression in @entity0 cells. Integrin b4 and PPARy were detected in tubulointerstitial tissues, immunohistochemistry analysis showed enhanced expression of integrin b4 in early stage, with over-expression at later stage. In contrast, the expression of PPARy showed little increased in early stage, but was dramatically decreased at later stage. This is consistent with @entity6 inducing EMT. Our immune-precipitation studies show that integrin b4 disassociation with PPARy is present in @entity8 signaling. It suggests that PPARy has a role in EMT inhibition.

title: Integrin b4 in EMT: an implication of XXXX .

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) is not uncommon in @entity0 and is an important cause of morbidity. Since information on @entity1 in Indian @entity0 is sparse, the study aimed at highlighting the salient features in them. MATERIALS AND METHODS: A questionnaire survey was done among 221 @entity0 and adolescents with @entity1 [ @entity3 ( @entity3 ) 93 (42.1  %); @entity2 ( @entity2 ) 122 (55.2  %); unclassified ( @entity1 -U) 6 (2.7  %)] across seven centers in India. The cut-off age was 18  years and below. RESULTS: The mean age of presentation for @entity3 and @entity2 was 10.2        4.4 and 11.0        4.5  years, respectively, with no gender difference. @entity4 (69.9  %, p   =   0.001) and blood in the stools (90.3  %, p   =   0.0001) were common in @entity3 , whereas @entity6 (73.8  %, p   =   0.01), fever (39.3  %, p   =   0.0001), @entity5 (64.7  %, p   =   0.001), and @entity8 (76.2  %, p   =   0.0001) were common in @entity2 . Extraintestinal manifestations (EIM) were a feature in 23.6 % and 36.1  % of @entity3 and @entity2 , respectively. Pancolitis (E3) was predominant in @entity3 (70.9  %) and 88  % required steroids. Ileocolonic @entity2 (L3) was common in 72.9  %; 76.2  % required azathioprine for maintenance. Of the @entity0 with @entity3 , 11.8  % had complications like @entity7 and toxic megacolon, while 27  % of @entity2 had fistulae, perianal abscess, stricture, and perforation. Biologicals were used in 0.8  % of severe @entity3 and in 12.2  % of @entity2 . In @entity3 , 4.3  % required surgical intervention. CONCLUSION: @entity1 ( @entity1 ) in India shares similarities with adult-onset @entity1 . Distinctive features were @entity8 and more severe forms of the disease necessitating immunomodulators.

title: A questionnaire survey of pediatric XXXX in India.

answer: @entity1


abstract: BACKGROUND: @entity0 with @entity5 ( @entity5 ) have increased risks for @entity4 than healthy @entity0 . This study aimed to explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of @entity5 . MATERIAL AND METHODS: We prospectively included 48 @entity5 @entity0 and 21 age- and sex-match healthy volunteers. There were 23 @entity0 with @entity6 ( @entity6 ) and 25 @entity0 with @entity2 ( @entity2 ). The @entity3 Scale (HADS) was administered to evaluate their psychosocial status. Upper endoscopy was performed with biopsy of the mucosa from the bulb of duodenum. Mast cells counts and degranulation rates were identified by @entity7 staining. The relationship among the scores of HADS-A ( @entity1 ) and HADS-D ( @entity3 ) and the mast cell counts and degranulation rates were analyzed. RESULTS: The scores of HADS-A and HADS-D were significantly higher in @entity6 and @entity2 @entity0 than the normal controls (P<0.05). The mast cell counts and degranulation rates in the duodenum were significantly increased in @entity6 and @entity2 @entity0 than the controls (P<0.05). In either @entity6 or @entity2 @entity0 , the HADS-A and HADS-D scores were positively correlated with the mast cell counts and degranulation rate. CONCLUSION: @entity5 @entity0 had significantly higher risks for @entity1 and @entity3 , which may lead to @entity5 through the increased mast cell counts and degranulation.

title: XXXX and @entity3 are associated with increased counts and degranulation of duodenal mast cells in @entity5 .

answer: @entity1


abstract: BACKGROUND: @entity0 with @entity5 ( @entity5 ) have increased risks for @entity4 than healthy @entity0 . This study aimed to explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of @entity5 . MATERIAL AND METHODS: We prospectively included 48 @entity5 @entity0 and 21 age- and sex-match healthy volunteers. There were 23 @entity0 with @entity6 ( @entity6 ) and 25 @entity0 with @entity2 ( @entity2 ). The @entity3 Scale (HADS) was administered to evaluate their psychosocial status. Upper endoscopy was performed with biopsy of the mucosa from the bulb of duodenum. Mast cells counts and degranulation rates were identified by @entity7 staining. The relationship among the scores of HADS-A ( @entity1 ) and HADS-D ( @entity3 ) and the mast cell counts and degranulation rates were analyzed. RESULTS: The scores of HADS-A and HADS-D were significantly higher in @entity6 and @entity2 @entity0 than the normal controls (P<0.05). The mast cell counts and degranulation rates in the duodenum were significantly increased in @entity6 and @entity2 @entity0 than the controls (P<0.05). In either @entity6 or @entity2 @entity0 , the HADS-A and HADS-D scores were positively correlated with the mast cell counts and degranulation rate. CONCLUSION: @entity5 @entity0 had significantly higher risks for @entity1 and @entity3 , which may lead to @entity5 through the increased mast cell counts and degranulation.

title: @entity1 and XXXX are associated with increased counts and degranulation of duodenal mast cells in @entity5 .

answer: @entity3


abstract: BACKGROUND: @entity0 with @entity5 ( @entity5 ) have increased risks for @entity4 than healthy @entity0 . This study aimed to explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of @entity5 . MATERIAL AND METHODS: We prospectively included 48 @entity5 @entity0 and 21 age- and sex-match healthy volunteers. There were 23 @entity0 with @entity6 ( @entity6 ) and 25 @entity0 with @entity2 ( @entity2 ). The @entity3 Scale (HADS) was administered to evaluate their psychosocial status. Upper endoscopy was performed with biopsy of the mucosa from the bulb of duodenum. Mast cells counts and degranulation rates were identified by @entity7 staining. The relationship among the scores of HADS-A ( @entity1 ) and HADS-D ( @entity3 ) and the mast cell counts and degranulation rates were analyzed. RESULTS: The scores of HADS-A and HADS-D were significantly higher in @entity6 and @entity2 @entity0 than the normal controls (P<0.05). The mast cell counts and degranulation rates in the duodenum were significantly increased in @entity6 and @entity2 @entity0 than the controls (P<0.05). In either @entity6 or @entity2 @entity0 , the HADS-A and HADS-D scores were positively correlated with the mast cell counts and degranulation rate. CONCLUSION: @entity5 @entity0 had significantly higher risks for @entity1 and @entity3 , which may lead to @entity5 through the increased mast cell counts and degranulation.

title: @entity1 and @entity3 are associated with increased counts and degranulation of duodenal mast cells in XXXX .

answer: @entity5


abstract: MAIN CONCLUSION: Abscisic acid mediates the effect of post-anthesis soil drying on grain filling through regulating the activities of key enzymes and expressions of genes involved in sucrose-to-starch conversion in @entity0 spikelets. This study investigated if abscisic acid (ABA) would mediate the effect of post-anthesis soil drying on grain filling through regulating the key enzymes in sucrose-to-starch conversion in @entity0 ( @entity0 .) spikelets. Two @entity0 cultivars were field-grown. Three treatments, @entity2 ( @entity2 ), @entity1 ( @entity1 ), and severe soil drying (SD), were imposed from 6  days after full heading until maturity. When compared with those under the @entity2 , grain filling rate, grain weight, and sink activity, in terms of the activities and gene expression levels of sucrose synthase, ADP glucose pyrophosphorylase, starch synthase, and starch branching enzyme, in inferior spikelets were substantially increased under the @entity1 , whereas they were markedly decreased in both superior and inferior spikelets under the SD. The two cultivars showed the same tendencies. Both @entity1 and SD increased ABA content and expression levels of its biosynthesis genes in spikelets, with more increase under the SD than the @entity1 . ABA content was significantly correlated with grain filling rate and sink activities under both @entity2 and @entity1 , while the correlations were not significant under the SD. Application of a low concentration ABA to @entity2 plants imitated the results under the @entity1 , and applying with a high concentration ABA showed the effect of the SD. The results suggest that ABA plays a vital role in grain filling through regulating sink activity and functions in a dose-dependent manner. An elevated ABA level under the @entity1 enhances, whereas a too high level of ABA under the SD decreases, sink activity.

title: Abscisic acid and the key enzymes and genes in sucrose-to-starch conversion in XXXX spikelets in response to soil drying during grain filling.

answer: @entity0


abstract: UNASSIGNED: The level of dietary protein determines the onset of reproduction, affects offspring growth and maturation, and hence influences life-history traits and fitness. However, to date, the long-term life-history consequences of @entity1 are not well understood. We studied the transgenerational effects of different levels of dietary protein on the life-history and level of maternal behavior of the striped @entity0 Rhabdomys dilectus chakae in captivity. Breeding pairs were assigned to three treatments based on the percentage of dietary protein: baseline (BP; 19%); @entity2 ( @entity2 ; 24%); and low protein (LP; 10%). Reproductive output and offspring ontogeny was diminished in the LP treatment compared to the other treatments. Transgenerational effects were studied by breeding F2 females raised on the LP or @entity2 diets on the same ( @entity2 , LP-LP) or altered diets ( @entity1 , LP- @entity2 ). The LP-LP treatment had no reproductive success, while reproductive capacity in the remaining treatments was determined mainly by the diet of mothers at breeding. Pups from protein-restricted females (LP, @entity1 ) showed post-weaning compensatory growth. Timing of sexual maturity was age-dependent in female and mass-dependent in male offspring. Females fed low protein diets during breeding (LP, @entity1 ) displayed lower levels of maternal behavior than females from the other treatments. This study demonstrates that the level of dietary protein influences the life-history of R. d. chakae in predictable ways. The taxon responds to changes in dietary protein at breeding, largely regardless of its nutrition during rearing. Such phenotypic flexibility in life-history parameters allows Rhabdomys to adaptively respond to unpredictable environmental changes. J. Exp. Zool. 323A: 97-108, 2015.    2015 Wiley Periodicals, Inc.

title: Dietary protein influences the life-history characteristics across generations in the African striped XXXX Rhabdomys.

answer: @entity0


abstract: Aim. To investigate the dynamic changes on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in the @entity0 chronic refractory cutaneous @entity1 after the autologous platelet-rich gel (APG) treatment. Methods. The study was developed at the @entity0 Care Centre, West China Hospital. The granulation tissues from the target wounds were taken before and within 15 days after APG application. The expression of @entity2 and @entity3 as well as @entity4 ( @entity4 ) in the granulation tissue was detected by q TR-PCR and IHC. The relationship between the expression level of @entity2 and @entity3 and their ratio and that of @entity4 was analyzed. Results. The expression of @entity2 (P < 0.05) was suppressed, and the expression of @entity3 (P < 0.05) was promoted, while the ratio of @entity2 / @entity3 (P < 0.05) was decreased after APG treatments. The expression of @entity4 had negative correlation with the ratio of @entity2 / @entity3 (P < 0.05) and positive correlation with the expression of @entity3 (P < 0.05). Conclusions. APG treatment may suppress the expression of @entity2 , promoting that of the @entity3 in the @entity0 chronic refractory cutaneous wounds. @entity4 may be related to these effects.

title: The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the XXXX Expression in the @entity0 .

answer: @entity2


abstract: Aim. To investigate the dynamic changes on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in the @entity0 chronic refractory cutaneous @entity1 after the autologous platelet-rich gel (APG) treatment. Methods. The study was developed at the @entity0 Care Centre, West China Hospital. The granulation tissues from the target wounds were taken before and within 15 days after APG application. The expression of @entity2 and @entity3 as well as @entity4 ( @entity4 ) in the granulation tissue was detected by q TR-PCR and IHC. The relationship between the expression level of @entity2 and @entity3 and their ratio and that of @entity4 was analyzed. Results. The expression of @entity2 (P < 0.05) was suppressed, and the expression of @entity3 (P < 0.05) was promoted, while the ratio of @entity2 / @entity3 (P < 0.05) was decreased after APG treatments. The expression of @entity4 had negative correlation with the ratio of @entity2 / @entity3 (P < 0.05) and positive correlation with the expression of @entity3 (P < 0.05). Conclusions. APG treatment may suppress the expression of @entity2 , promoting that of the @entity3 in the @entity0 chronic refractory cutaneous wounds. @entity4 may be related to these effects.

title: The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the @entity2 Expression in the XXXX .

answer: @entity0


abstract: BACKGROUND: @entity4 ( @entity4 ) of the humeral head is a known @entity3 . Prosthetic replacement may be the last option to treat the associated @entity1 . Depending on the condition of the glenoid, hemiarthroplasty (HA) or @entity2 ( @entity2 ) can be considered. To date, the peer reviewed literature offers limited direction on the better treatment for this population. METHODS: Between 1973 and 2010, 93 arthroplasties were performed for post-traumatic @entity4 of the humeral head after conservative treatments failed. Of these, 37 HAs and 46 TSAs were monitored for a minimum of 2  years (mean, 8.9  years) or until reoperation. RESULTS: The HA and @entity2 groups showed improvements in @entity1 (P  <  .001), elevation (P  <  .01), and external rotation (P  <  .01). The @entity2 group had less @entity1 at follow-up than the HA group (2.1 vs 3.0, P  =  .001). @entity2 led to better satisfaction (70% vs 56%) and more excellent/satisfactory Neer ratings (57% vs 41%) compared with HA. Nine HA @entity0 and 5 @entity2 @entity0 underwent reoperation. The most common causes for reoperation were @entity1 glenoid @entity5 (n = 8) in HA and rotator cuff failure (n = 4) in @entity2 . The estimated 15-year survivorship was 79.5% for HA and 83% for @entity2 . DISCUSSION: In @entity0 with post-traumatic @entity4 of the humeral head, shoulder arthroplasty provides improvements in range of motion. However, @entity2 provides superior @entity1 relief, with better @entity0 -reported satisfaction. @entity2 should be strongly considered in @entity0 with post-traumatic @entity4 of the humeral head with damage to the glenoid cartilage.

title: Shoulder arthroplasty for post-traumatic XXXX of the humeral head.

answer: @entity4


abstract: BACKGROUND: The epidemiology of @entity1 [ @entity1 ] in Eastern Europe is poorly understood, particularly with regard to diagnostic delay. Here we investigated the factors leading to delayed diagnosis and the effect of the delay on several disease progression and outcome measures. METHODS: A total of 1196 @entity1 cases [682 @entity3 [ @entity3 ], 478 @entity2 [ @entity2 ], 36 indeterminate @entity5 ] from the Romanian national registry IBDPROSPECT were reviewed. Standard clinical and demographic factors were evaluated as predictors of a long diagnostic delay in both @entity2 and @entity3 . Diagnostic delay was subsequently evaluated as a potential risk factor for bowel stenoses, bowel @entity4 , perianal @entity4 , perianal surgery, and intestinal surgery in @entity2 @entity0 . RESULTS: The median diagnostic delay was significantly longer in @entity2 [5 months] than in @entity3 [1 month] @entity0 [p < 0.001]. Compared with 5 months for @entity3 @entity0 , 75% of @entity2 @entity0 were diagnosed within 18 months of symptom onset. In @entity2 @entity0 , extra-ileal location was a protective factor (odds ratio [OR], 0.5; p = 0.03), whereas being an active smoker [OR, 2.09; p = 0.01] and symptom onset during summer [OR, 3.35; p < 0.001] were independent risk factors for a long diagnostic delay [> 18 months]. In @entity3 @entity0 , an age > 40 years was a protective factor [OR, 0.68; p = 0.04] for a long delay. Regarding outcomes, a long diagnostic delay in @entity2 @entity0 positively correlated with bowel stenoses [OR, 3.38; p < 0.01] and any @entity1 -related surgery [OR, 1.95; p = 0.03] and had a positive trend for intestinal @entity4 [OR, 2.64; p = 0.08] and perianal @entity4 [OR, 2.9; p = 0.07]. Disease duration since diagnosis positively correlated with bowel stenoses [OR, 1.04; p = 0.04], any @entity1 -related surgery [OR, 1.04; p = 0.02], and intestinal surgery [OR, 1.07; p < 0.01]. CONCLUSIONS: A long diagnostic delay in @entity1 correlates with an increased frequency of bowel stenoses and need for @entity1 -related surgery.

title: Diagnostic Delay in Romanian @entity0 with XXXX : Risk Factors and Impact on the Disease Course and Need for Surgery.

answer: @entity1


abstract: BACKGROUND: The epidemiology of @entity1 [ @entity1 ] in Eastern Europe is poorly understood, particularly with regard to diagnostic delay. Here we investigated the factors leading to delayed diagnosis and the effect of the delay on several disease progression and outcome measures. METHODS: A total of 1196 @entity1 cases [682 @entity3 [ @entity3 ], 478 @entity2 [ @entity2 ], 36 indeterminate @entity5 ] from the Romanian national registry IBDPROSPECT were reviewed. Standard clinical and demographic factors were evaluated as predictors of a long diagnostic delay in both @entity2 and @entity3 . Diagnostic delay was subsequently evaluated as a potential risk factor for bowel stenoses, bowel @entity4 , perianal @entity4 , perianal surgery, and intestinal surgery in @entity2 @entity0 . RESULTS: The median diagnostic delay was significantly longer in @entity2 [5 months] than in @entity3 [1 month] @entity0 [p < 0.001]. Compared with 5 months for @entity3 @entity0 , 75% of @entity2 @entity0 were diagnosed within 18 months of symptom onset. In @entity2 @entity0 , extra-ileal location was a protective factor (odds ratio [OR], 0.5; p = 0.03), whereas being an active smoker [OR, 2.09; p = 0.01] and symptom onset during summer [OR, 3.35; p < 0.001] were independent risk factors for a long diagnostic delay [> 18 months]. In @entity3 @entity0 , an age > 40 years was a protective factor [OR, 0.68; p = 0.04] for a long delay. Regarding outcomes, a long diagnostic delay in @entity2 @entity0 positively correlated with bowel stenoses [OR, 3.38; p < 0.01] and any @entity1 -related surgery [OR, 1.95; p = 0.03] and had a positive trend for intestinal @entity4 [OR, 2.64; p = 0.08] and perianal @entity4 [OR, 2.9; p = 0.07]. Disease duration since diagnosis positively correlated with bowel stenoses [OR, 1.04; p = 0.04], any @entity1 -related surgery [OR, 1.04; p = 0.02], and intestinal surgery [OR, 1.07; p < 0.01]. CONCLUSIONS: A long diagnostic delay in @entity1 correlates with an increased frequency of bowel stenoses and need for @entity1 -related surgery.

title: Diagnostic Delay in Romanian XXXX with @entity1 : Risk Factors and Impact on the Disease Course and Need for Surgery.

answer: @entity0


abstract: UNASSIGNED: Cellular senescence is characterized by irreversible cell arrest and is associated with the development of @entity3 , including @entity0 . Here, we investigated the induction of cellular senescence during @entity5 . @entity2 was induced in Fischer 344 @entity1 with a weekly intraperitoneal injection of @entity4 (50mg/kg body weight) for 16 weeks. Double-detection of b-galactosidase with Ki67 for cell proliferation; a-SMA and @entity11 for cell specificity; @entity8 , @entity6 , @entity9 , and @entity10 , @entity13 , and @entity12 for senescence-associated molecular pathways and y-glutamyltranspeptidase (GGT) for hepatocarcinogenesis was assessed to determine the association of these markers with cellular senescence. DNA damage was measured through @entity7 ( @entity7 ) detection. Progressive cellular senescence was observed in both fibrotic septa and hepatocytes from week 10 to 18. The maximum peak of positive senescent and fibrotic cells was observed at week 16 and decreased at week 18, but cell proliferation remained high. Whereas the increased @entity9 expression and @entity7 were concomitant with that of b-galactosidase, those of @entity8 and @entity6 were barely detected. Furthermore, b-galactosidase positive myofibroblast-like cells were mainly surrounding @entity0 . Our findings showed that in hepatocarcinogenesis by @entity4 , cellular senescence is associated with @entity9 pathway activation and is mainly localized in myofibroblast-like cells.

title: Double staining of b-galactosidase with fibrosis and @entity0 markers reveals the chronological appearance of senescence in @entity5 induced by XXXX .

answer: @entity4


abstract: UNASSIGNED: Cellular senescence is characterized by irreversible cell arrest and is associated with the development of @entity3 , including @entity0 . Here, we investigated the induction of cellular senescence during @entity5 . @entity2 was induced in Fischer 344 @entity1 with a weekly intraperitoneal injection of @entity4 (50mg/kg body weight) for 16 weeks. Double-detection of b-galactosidase with Ki67 for cell proliferation; a-SMA and @entity11 for cell specificity; @entity8 , @entity6 , @entity9 , and @entity10 , @entity13 , and @entity12 for senescence-associated molecular pathways and y-glutamyltranspeptidase (GGT) for hepatocarcinogenesis was assessed to determine the association of these markers with cellular senescence. DNA damage was measured through @entity7 ( @entity7 ) detection. Progressive cellular senescence was observed in both fibrotic septa and hepatocytes from week 10 to 18. The maximum peak of positive senescent and fibrotic cells was observed at week 16 and decreased at week 18, but cell proliferation remained high. Whereas the increased @entity9 expression and @entity7 were concomitant with that of b-galactosidase, those of @entity8 and @entity6 were barely detected. Furthermore, b-galactosidase positive myofibroblast-like cells were mainly surrounding @entity0 . Our findings showed that in hepatocarcinogenesis by @entity4 , cellular senescence is associated with @entity9 pathway activation and is mainly localized in myofibroblast-like cells.

title: Double staining of b-galactosidase with fibrosis and @entity0 markers reveals the chronological appearance of senescence in XXXX induced by @entity4 .

answer: @entity5


abstract: UNASSIGNED: Cellular senescence is characterized by irreversible cell arrest and is associated with the development of @entity3 , including @entity0 . Here, we investigated the induction of cellular senescence during @entity5 . @entity2 was induced in Fischer 344 @entity1 with a weekly intraperitoneal injection of @entity4 (50mg/kg body weight) for 16 weeks. Double-detection of b-galactosidase with Ki67 for cell proliferation; a-SMA and @entity11 for cell specificity; @entity8 , @entity6 , @entity9 , and @entity10 , @entity13 , and @entity12 for senescence-associated molecular pathways and y-glutamyltranspeptidase (GGT) for hepatocarcinogenesis was assessed to determine the association of these markers with cellular senescence. DNA damage was measured through @entity7 ( @entity7 ) detection. Progressive cellular senescence was observed in both fibrotic septa and hepatocytes from week 10 to 18. The maximum peak of positive senescent and fibrotic cells was observed at week 16 and decreased at week 18, but cell proliferation remained high. Whereas the increased @entity9 expression and @entity7 were concomitant with that of b-galactosidase, those of @entity8 and @entity6 were barely detected. Furthermore, b-galactosidase positive myofibroblast-like cells were mainly surrounding @entity0 . Our findings showed that in hepatocarcinogenesis by @entity4 , cellular senescence is associated with @entity9 pathway activation and is mainly localized in myofibroblast-like cells.

title: Double staining of b-galactosidase with fibrosis and XXXX markers reveals the chronological appearance of senescence in @entity5 induced by @entity4 .

answer: @entity0


abstract: BACKGROUND: Coverage of the UK National Health Service Cervical Screening Programme is declining. Under-screened @entity0 whose daughters participate in the @entity2 ) vaccination programme could be stimulated to attend. We investigated whether factors associated with the vaccination programme changed mothers' intentions for future screening. METHODS: Questionnaires were sent to mothers of @entity0 aged 12-13   years across two North West primary care trusts (n=2387) to assess the effect of the HPV vaccination programme on screening intentions. This identified mothers whose intentions had changed. Consent was sought to contact them for a semi-structured interview to discuss their screening intentions. Key themes were identified using framework analysis. RESULTS: 97/606 @entity0 responding to the questionnaire had changed their views about cervical screening. 23 @entity0 were interviewed, 10 of whom expressed a positive change and 13 no change. Most had discussed the vaccine information, including cervical screening, with their daughters. Mothers who made a positive change decision recognised their daughters' risk of @entity1 , the need for future screening, and the importance of their own example. In this way daughters became 'significant others' in reinforcing their mothers' cervical screening motivation. CONCLUSIONS: A daughter's invitation for HPV vaccination instigates a reassessment of cervical screening intention in some under-screened mothers.

title: A qualitative study to assess the potential of the XXXX vaccination programme to encourage under-screened mothers to attend for cervical screening.

answer: @entity2


abstract: It is well known that @entity3 has an adverse effect on postoperative outcomes. However, what is still unknown is how to appropriately risk stratify this @entity0 population based on the degree of @entity6 . Because data are limited, specifically in general surgery practice, we analyzed the @entity7 ( @entity7 ) in terms of predicting @entity2 after one of three general surgery operations: @entity1 ( @entity1 ), @entity8 ( @entity8 ), and colon resection (CRXN). National Surgical Quality Improvement Program data on 17,812 total @entity0 undergoing one of three general surgery operations from 2008 to 2012 were analyzed retrospectively. There were 7402 @entity0 undergoing @entity1 ; 5014 @entity0 undergoing @entity8 ; 5396 @entity0 undergoing CRXN. @entity7 score was calculated using international normalized ratio, total @entity4 , and @entity5 . The primary end point was any @entity2 . The statistical method used was logistic regression. For @entity1 , @entity8 , and CRXN, the overall complication rates were 3.4, 6.4, and 45.9 per cent, respectively. The mean @entity7 scores were 8.6, 8.5, and 8.5, respectively. For every 1-point increase greater than the mean @entity7 score, there was a 7.8, 13.8, and 11.6 per cent increase in any @entity2 . The overall 30-day mortality rate was 0.9 per cent. In conclusion, the @entity7 score continuum adequately predicts @entity0 ' increased risk of @entity2 after @entity1 , @entity8 , and CRXN. Therefore, @entity7 could be used for preoperative risk stratification and guide clinical decision making for general surgery in the cirrhotic @entity0 .

title: A NSQIP Analysis of XXXX and Perioperative Outcomes in General Surgery.

answer: @entity7


abstract: BACKGROUND: @entity3 causes @entity4 and often leads to @entity1 and @entity2 without treatment. We wanted to see if having access to primary care or insurance prior to diagnosis is associated with better outcomes for @entity0 in an urban, public hospital with mostly socioeconomically disadvantaged Hispanic @entity0 . METHODS: We did a retrospective study at our institution. Kaplan Meier survival analysis was done looking at transplant-free overall survival for @entity0 diagnosed at our institution. The log-rank test was done to compare survival between @entity0 with and without prior access to primary care, and between @entity0 with and without insurance at diagnosis. RESULTS: Overall 5- and 10-year transplant-free overall survival was 91  % (95  % CI, 83-100  %) and 75  % (95  % CI, 50-99  %), respectively. @entity0 with primary care prior to diagnosis had significantly better transplant-free overall survival than those without (log rank test p   =   0.019). @entity0 with primary care also had better clinical markers at diagnosis. Having insurance at diagnosis was not associated with better outcomes. CONCLUSIONS: Outcomes of @entity3 are poor in our setting but access to primary care prior to diagnosis was associated with better outcomes. This is likely due to the important role that primary care plays in detecting disease and initiating treatment earlier. With the expansion of access to healthcare that the Affordable Care Act provides, future @entity0 are likely to do better with even rare diseases like @entity3 .

title: Access to primary care is associated with better XXXX outcomes in an urban county hospital.

answer: @entity3


abstract: PURPOSE: To study the long-term outcome of @entity1 surgery with primary intraocular lens (IOL) in @entity0 <2 years. MATERIALS AND METHODS: Retrospective analysis of bilateral cases that were operated before 2 years age for congenital @entity1 . All underwent primary posterior capsulotomy with anterior vitrectomy and primary @entity2 . Only those with a follow-up of at least 8 years were evaluated. RESULTS: Twenty-six eyes of 13 @entity0 with bilateral @entity1 met the inclusion criteria. Average age at surgery was 14.15 months with a mean follow-up of 102 months. Average preoperative @entity3 ( @entity3 ) was 19.93 mm. There was a refractive shift from a mean spherical equivalent of 1.64 D at 2 weeks after surgery to -1.42 D measured at last follow-up. Twenty-four eyes out of 26 (92%) achieved final visual acuity (VA) of 6/18 or more at last follow-up with 19/26 (73%) having acuity of 6/12 or greater. Raised intraocular pressure was documented in one eye only. Average @entity3 recorded at last follow-up was 22.21 mm. CONCLUSION: Primary @entity2 in @entity0 <2 years is a safe surgical procedure with excellent long-term results. The myopic shift is well-controlled and final VA achieved is reasonably good.

title: Long-term results after primary intraocular lens implantation in @entity0 operated less than 2 years of age for congenital XXXX .

answer: @entity1


abstract: PURPOSE: To study the long-term outcome of @entity1 surgery with primary intraocular lens (IOL) in @entity0 <2 years. MATERIALS AND METHODS: Retrospective analysis of bilateral cases that were operated before 2 years age for congenital @entity1 . All underwent primary posterior capsulotomy with anterior vitrectomy and primary @entity2 . Only those with a follow-up of at least 8 years were evaluated. RESULTS: Twenty-six eyes of 13 @entity0 with bilateral @entity1 met the inclusion criteria. Average age at surgery was 14.15 months with a mean follow-up of 102 months. Average preoperative @entity3 ( @entity3 ) was 19.93 mm. There was a refractive shift from a mean spherical equivalent of 1.64 D at 2 weeks after surgery to -1.42 D measured at last follow-up. Twenty-four eyes out of 26 (92%) achieved final visual acuity (VA) of 6/18 or more at last follow-up with 19/26 (73%) having acuity of 6/12 or greater. Raised intraocular pressure was documented in one eye only. Average @entity3 recorded at last follow-up was 22.21 mm. CONCLUSION: Primary @entity2 in @entity0 <2 years is a safe surgical procedure with excellent long-term results. The myopic shift is well-controlled and final VA achieved is reasonably good.

title: Long-term results after primary intraocular lens implantation in XXXX operated less than 2 years of age for congenital @entity1 .

answer: @entity0


abstract: OBJECTIVES: Aim of this prospective study was to investigate prognostic significance of increased bone marrow microcirculation as detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for survival and local complications in @entity0 with @entity4 ( @entity4 ). METHODS: We performed DCE-MRI of the lumbar spine in 131 @entity0 with newly diagnosed @entity4 and analysed data according to the @entity6 model to acquire amplitude A and exchange rate constant k ep. In 61 @entity0 a second MRI performed after therapy was evaluated to assess changes in vertebral height and identify @entity3 . RESULTS: Correlation analysis revealed significant positive association between @entity5 as well as immunoparesis with DCE-MRI parameters A and k ep. Additionally, A was negatively correlated with haemoglobin levels and k ep was positively correlated with LDH levels. Higher baseline k ep values were associated with decreased vertebral height in a second MRI (P   =   0.007) and A values were associated with new @entity3 in the lower lumbar spine (P   =   0.03 for L4). Pre-existing @entity1 or remission after therapy had no impact on the occurrence of @entity3 . Multivariate analysis revealed that amplitude A is an independent adverse risk factor for overall survival. CONCLUSION: DCE-MRI is a non-invasive tool with significance for @entity2 . KEY POINTS:     Qualitative parameters from DCE-MRI are correlated with established factors of disease activity     Increased marrow microcirculation might be a risk factor for @entity3     Amplitude A is an independent predictor for shortened overall survival.

title: Prognostic significance of increased bone marrow microcirculation in newly diagnosed XXXX : results of a prospective DCE-MRI study.

answer: @entity4


abstract: Background: Placebo controls are essential in evaluating the effectiveness of medical treatments. Although it is unclear whether different placebo interventions for @entity1 vary in efficacy, systematic differences would substantially affect interpretation of the results of placebo-controlled trials. Objective: To evaluate the effects of alternative placebo types on @entity0 outcomes in @entity2 . Data Sources: MEDLINE, EMBASE, Web of Science, Google Scholar, and Cochrane Database from inception through 1 June 2015 and unpublished data. Study Selection: 149 randomized trials of adults with @entity2 that reported @entity0 outcomes and compared widely used pharmaceuticals against oral, intra-articular, topical, and oral plus topical placebos. Data Extraction: Study data were independently double-extracted; study quality was assessed by using the Cochrane risk of bias tool. Data Synthesis: Placebo effects that were evaluated by using a network meta-analysis with 4 separate placebo nodes (differential model) showed that intra-articular placebo (effect size, 0.29 [95% credible interval, 0.09 to 0.49]) and topical placebo (effect size, 0.20 [credible interval, 0.02 to 0.38]) had significantly greater effect sizes than did oral placebo. This differential model showed marked differences in the relative efficacies and hierarchy of the active treatments compared with a network model that considered all placebos equivalent. In the model accounting for differential effects, intra-articular and topical therapies were superior to oral treatments in @entity0 . When these differential effects were ignored, oral nonsteroidal anti-inflammatory drugs were superior. Limitations: Few studies compared different placebos directly. The study could not decisively conclude whether disease severity and co-interventions systematically differed between trials evaluating different placebos. Conclusion: All placebos are not equal, and some can trigger clinically relevant responses. Differential placebo effects can substantially alter estimates of the relative efficacies of active treatments, an important consideration for the design of clinical trials and interpretation of their results. Primary Funding Source: Agency for Healthcare Research and Quality.

title: Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network Meta-analysis of XXXX Trials.

answer: @entity1


abstract: UNASSIGNED: Apocynum venetum, a Chinese medicinal herb, is reported to be neuroprotective. However, whether apocynum venetum leaf extract (AVLE) protects against @entity1 remains elusive. Our present study was aimed to observe the effects of AVLE preconditioning on @entity2 /reperfusion (MI/R) injury and to investigate the possible mechanisms. @entity0 were treated with AVLE (500 mg/kg/d, o.g.) or distilled water once daily for one week. Afterward, all the animals were subjected to 30 min of @entity2 followed by 4 h of reperfusion. AVLE preconditioning for one week significantly improved cardiac function following MI/R. Meanwhile, AVLE reduced @entity3 size, plasma creatine kinase (CK)/lactate dehydrogenase (LDH) activities and myocardial apoptosis at the end of reperfusion in @entity0 hearts. Moreover, AVLE preconditioning significantly inhibited superoxide generation, gp91(phox) expression, malonaldialdehyde formation and enhanced superoxide dismutase (SOD) activity in I/R hearts. Furthermore, AVLE treatment increased Akt and extracellular regulated protein kinases 1/2 ( @entity4 ) phosphorylations in I/R @entity0 heart. Either the Phosphatidylinositide 3-kinase (PI3K) inhibitor wortmannin or the @entity4 inhibitor @entity5 blocked AVLE-stimulated anti-oxidative effects and cardioprotection. Our study demonstrated for the first time that AVLE reduces oxidative stress and exerts cardioprotection against MI/R injury in @entity0 .

title: Apocynum Venetum Leaf Attenuates XXXX /Reperfusion Injury by Inhibiting Oxidative Stress.

answer: @entity2


abstract: BACKGROUND: Psychological factors may influence persistence and perceived severity of symptoms in @entity4 ( @entity5 ). Literature suggests that somatisation is associated with @entity5 . However, the relationship between @entity5 subtype, symptoms of @entity5 and somatisation is unclear. AIM: To examine this issue in a large cohort of secondary care @entity0 . METHODS: Demographic and gastrointestinal (GI) symptom data were collected from 4224 adult @entity0 via the Rome III questionnaire. Somatisation data were collected using the @entity0 health questionnaire-12. Mean somatisation score and number of somatic symptoms were compared between @entity5 @entity0 and controls with minimal @entity2 , and between @entity5 subtypes using analysis of variance. Effect of level of somatisation on symptom frequency was compared according to @entity5 subtype using a   (2) test. RESULTS: 840 @entity0 met Rome III criteria for @entity5 , controls were 2137 @entity0 with @entity2 without @entity5 . Mean somatisation scores and number of somatic symptoms were higher in @entity5 vs. controls (P  <  0.001), and in mixed stool pattern @entity5 ( @entity5 ), vs. @entity5 with @entity3 ( @entity5 -C) or @entity1 ( @entity5 -D) (P  <  0.001). High levels of somatisation were more prevalent in @entity5 (31.7%) vs. @entity5 -C (22.5%) or @entity5 -D (20.8%) (P  =  0.003). For all @entity5 subtypes, high levels of somatisation were associated with a greater frequency of bloating or abdominal distension prior to logistic regression. CONCLUSIONS: @entity5 is strongly associated with higher levels of somatisation, particularly @entity5 . Bloating may be associated with higher levels of somatisation, perhaps explaining why it can be difficult to treat.

title: XXXX is significantly associated with somatisation in 840 @entity0 , which may drive bloating.

answer: @entity4


abstract: BACKGROUND: Psychological factors may influence persistence and perceived severity of symptoms in @entity4 ( @entity5 ). Literature suggests that somatisation is associated with @entity5 . However, the relationship between @entity5 subtype, symptoms of @entity5 and somatisation is unclear. AIM: To examine this issue in a large cohort of secondary care @entity0 . METHODS: Demographic and gastrointestinal (GI) symptom data were collected from 4224 adult @entity0 via the Rome III questionnaire. Somatisation data were collected using the @entity0 health questionnaire-12. Mean somatisation score and number of somatic symptoms were compared between @entity5 @entity0 and controls with minimal @entity2 , and between @entity5 subtypes using analysis of variance. Effect of level of somatisation on symptom frequency was compared according to @entity5 subtype using a   (2) test. RESULTS: 840 @entity0 met Rome III criteria for @entity5 , controls were 2137 @entity0 with @entity2 without @entity5 . Mean somatisation scores and number of somatic symptoms were higher in @entity5 vs. controls (P  <  0.001), and in mixed stool pattern @entity5 ( @entity5 ), vs. @entity5 with @entity3 ( @entity5 -C) or @entity1 ( @entity5 -D) (P  <  0.001). High levels of somatisation were more prevalent in @entity5 (31.7%) vs. @entity5 -C (22.5%) or @entity5 -D (20.8%) (P  =  0.003). For all @entity5 subtypes, high levels of somatisation were associated with a greater frequency of bloating or abdominal distension prior to logistic regression. CONCLUSIONS: @entity5 is strongly associated with higher levels of somatisation, particularly @entity5 . Bloating may be associated with higher levels of somatisation, perhaps explaining why it can be difficult to treat.

title: @entity4 is significantly associated with somatisation in 840 XXXX , which may drive bloating.

answer: @entity0


abstract: @entity1 is a hallmark symptom of many @entity2 . In substance use disorders, @entity1 is triply harmful (a) because addicts increasingly prefer the drug of abuse to the natural reward of drug-free social interaction, thus worsening the progression of the disease by increasing their drug consumption, (b) because treatment adherence and, consequently, treatment success itself depends on the ability of the recovering addict to maintain social interaction and adhere to treatment, and (c) because socially interacting with an individual suffering from a substance use disorder may be harmful for others. Helping the addict reorient his/her behavior away from the drug of abuse toward social interaction would therefore be of considerable therapeutic benefit. This article reviews our work on the neural basis of such a reorientation from @entity4 , as a prototypical drug of abuse, toward dyadic (i.e. one-to-one) social interaction and compares our findings with the effects of other potentially beneficial interventions, that is, environmental enrichment or paired housing, on the activation of the accumbens and other brain regions involved in behavior motivated by drugs of abuse or nondrug stimuli. Our experimental models are based on the conditioned place preference paradigm. As the therapeutically most promising finding, only four 15 min episodes of @entity5 were able to inhibit both the subsequent reacquisition/re-expression of preference for @entity4 and the neural activation associated with this behavior, that is, an increase in the expression of the @entity6 gene @entity7 ( @entity7 , @entity7 ) in the nucleus accumbens, basolateral and central amygdala, and the ventral tegmental area. The time spent in the @entity4 -associated conditioning compartment was correlated with the density of @entity7 -activated neurons not only in the medial core (AcbCm) and medial shell (AcbShm) of the nucleus accumbens, but was observed in all regions medial to the anterior commissure ('accumbens corridor'), including (from medial to lateral), the vertical limb of the diagonal band and the medial septum (VDB+MS), the major island of Calleja and the intermediate nucleus of the lateral septum (ICjM+LSI), the AcbShm, and the AcbCm. All effects were limited to GABAergic projection neurons (called 'medium spiny neurons', in the accumbens), encompassing both @entity3 D1 receptor-expressing and D2 receptor-expressing medium spiny neuron subtypes. Our @entity7 expression findings were mirrored in multielectrode array recordings. Finally, we have validated our paradigm in C57BL/6 @entity0 to make use of the plethora of transgenic models available in this genus.

title: Dyadic social interaction inhibits XXXX -conditioned place preference and the associated activation of the accumbens corridor.

answer: @entity4


abstract: In two previous communications we demonstrated that @entity4 (T3) improved cases of chronic @entity3 (CBA). In this communication we administered T3 in a dose of 40 microgram/day for a period of sixty days to twelve cases of CBA aged less than 38 years who had had the condition for more than 5 years and were not on @entity1 or chromoglycate. All were outpatients. Respiratory functions including vital capacity and timed expiratory volume were tested before and after the period of drug administration. @entity0 were also advised to record the number of attacks and amount of bronchodilators used. All @entity0 had their % T3 uptake and @entity5 (T4) serum level examined before the experiment. Ten normal @entity0 of matching ages and sexes had their blood examined for % T3 uptake and levels as control. The results have shown that the @entity0 had normal % T3 uptake and T4 levels in blood. Their vital capacity increased by an average of 4.27%, their first-second expiratory volume by 17.58% (P less than 0.0025), their second-second expiratory volume by 13.74% (P less than 0.0025%), and their maximal ventilatory volume by 12.95% (P less than 0.0025). Five cases had an increase of over 20% and 5 cases had practically no increase or a mild reduction. Subjective improvement and reduction in amount of bronchodilators used correlated well with the improvement in ventilation. It is argued that T3 acts through having the capacity to increase @entity2 , a main messenger in bronchodilation that is known to be deficient in asthmatics.

title: Effect of XXXX on Bronchial Asthma. III.

answer: @entity4


abstract: UNASSIGNED: Diagnosis of @entity2 ( @entity3 ) relies on well-defined cytomorphologic criteria but is challenging in a significant number of @entity0 . The detection of aberrant antigen expression by multiparameter flow cytometry (MFC) is considered a promising tool to improve @entity3 diagnostics. We prospectively analyzed 804 unselected @entity0 sent with suspected @entity3 for correlation of MFC findings with @entity1 ( @entity1 ) in the context of cytomorphologic and cytogenetic findings. @entity0 with evidence of @entity3 by MFC had a significantly worse @entity1 as compared to those without ( @entity1 at 2 years, 71.2% vs. 89.4%; P   <   0.001). The number of aberrantly expressed antigens as a continuous variable was significantly associated with @entity1 [P   <   0.001, hazards ratio (HR): 1.19 per additional aberrantly expressed antigen]. Multivariate analysis proved a diagnosis of @entity3 by MFC to be independently associated with @entity1 (P   =   0.050; HR: 1.42). Furthermore, a diagnosis of @entity3 by MFC was related to inferior survival within all three cytomorphologically defined subgroups, i.e., proven @entity3 ( @entity3 , 45.4 vs. 52.8 months, P   <   0.001), suspected @entity3 (2-year- @entity1 , 75.0% vs. 82.8%; P   =   0.062), and @entity3 excluded (2-year- @entity1 , 63.5% vs. 92.8%, P   =   0.020). Our data clearly demonstrate that, in the assessment of cytopenic @entity0 with suspected @entity3 , a diagnosis of @entity3 by MFC is independently associated with @entity1 , which had been shown in previous studies for today's standard diagnostic parameters cytomorphology and cytogenetics. MFC may, therefore, be considered an additional tool in the diagnostic workup of @entity0 with suspected @entity3 .    2015 International Clinical Cytometry Society.

title: Multiparameter flow cytometry provides independent prognostic information in @entity0 with suspected XXXX : A study on 804 @entity0 .

answer: @entity2


abstract: UNASSIGNED: Diagnosis of @entity2 ( @entity3 ) relies on well-defined cytomorphologic criteria but is challenging in a significant number of @entity0 . The detection of aberrant antigen expression by multiparameter flow cytometry (MFC) is considered a promising tool to improve @entity3 diagnostics. We prospectively analyzed 804 unselected @entity0 sent with suspected @entity3 for correlation of MFC findings with @entity1 ( @entity1 ) in the context of cytomorphologic and cytogenetic findings. @entity0 with evidence of @entity3 by MFC had a significantly worse @entity1 as compared to those without ( @entity1 at 2 years, 71.2% vs. 89.4%; P   <   0.001). The number of aberrantly expressed antigens as a continuous variable was significantly associated with @entity1 [P   <   0.001, hazards ratio (HR): 1.19 per additional aberrantly expressed antigen]. Multivariate analysis proved a diagnosis of @entity3 by MFC to be independently associated with @entity1 (P   =   0.050; HR: 1.42). Furthermore, a diagnosis of @entity3 by MFC was related to inferior survival within all three cytomorphologically defined subgroups, i.e., proven @entity3 ( @entity3 , 45.4 vs. 52.8 months, P   <   0.001), suspected @entity3 (2-year- @entity1 , 75.0% vs. 82.8%; P   =   0.062), and @entity3 excluded (2-year- @entity1 , 63.5% vs. 92.8%, P   =   0.020). Our data clearly demonstrate that, in the assessment of cytopenic @entity0 with suspected @entity3 , a diagnosis of @entity3 by MFC is independently associated with @entity1 , which had been shown in previous studies for today's standard diagnostic parameters cytomorphology and cytogenetics. MFC may, therefore, be considered an additional tool in the diagnostic workup of @entity0 with suspected @entity3 .    2015 International Clinical Cytometry Society.

title: Multiparameter flow cytometry provides independent prognostic information in XXXX with suspected @entity2 : A study on 804 @entity0 .

answer: @entity0


abstract: UNASSIGNED: Diagnosis of @entity2 ( @entity3 ) relies on well-defined cytomorphologic criteria but is challenging in a significant number of @entity0 . The detection of aberrant antigen expression by multiparameter flow cytometry (MFC) is considered a promising tool to improve @entity3 diagnostics. We prospectively analyzed 804 unselected @entity0 sent with suspected @entity3 for correlation of MFC findings with @entity1 ( @entity1 ) in the context of cytomorphologic and cytogenetic findings. @entity0 with evidence of @entity3 by MFC had a significantly worse @entity1 as compared to those without ( @entity1 at 2 years, 71.2% vs. 89.4%; P   <   0.001). The number of aberrantly expressed antigens as a continuous variable was significantly associated with @entity1 [P   <   0.001, hazards ratio (HR): 1.19 per additional aberrantly expressed antigen]. Multivariate analysis proved a diagnosis of @entity3 by MFC to be independently associated with @entity1 (P   =   0.050; HR: 1.42). Furthermore, a diagnosis of @entity3 by MFC was related to inferior survival within all three cytomorphologically defined subgroups, i.e., proven @entity3 ( @entity3 , 45.4 vs. 52.8 months, P   <   0.001), suspected @entity3 (2-year- @entity1 , 75.0% vs. 82.8%; P   =   0.062), and @entity3 excluded (2-year- @entity1 , 63.5% vs. 92.8%, P   =   0.020). Our data clearly demonstrate that, in the assessment of cytopenic @entity0 with suspected @entity3 , a diagnosis of @entity3 by MFC is independently associated with @entity1 , which had been shown in previous studies for today's standard diagnostic parameters cytomorphology and cytogenetics. MFC may, therefore, be considered an additional tool in the diagnostic workup of @entity0 with suspected @entity3 .    2015 International Clinical Cytometry Society.

title: Multiparameter flow cytometry provides independent prognostic information in @entity0 with suspected @entity2 : A study on 804 XXXX .

answer: @entity0


abstract: PURPOSE: @entity1 ( @entity1 ) is a rare benign @entity1 . The purpose of this study was to review the clinical characteristics, imaging and pathological features, and outcomes of @entity0 with IMTs from a single center in China. METHODS: A retrospective file review was conducted involving 23 cases of pathologically confirmed IMTs treated at the @entity0 's Hospital between April 2003 and April 2014. RESULTS: The @entity1 locations included multiple anatomic sites, as follows: abdomen or pelvis (n  =  17); lungs (n  =  2); head and neck (n  =  1); trunk (n  =  1); and extremities (n  =  2). The @entity1 were associated with various clinical presentations. The predominant symptoms included an anemic appearance, fevers, and an asymptomatic mass. Computed tomography scanning showed solid, heterogeneous, well-demarcated masses; the appearance of enhancement was variable. MRI appeared hypointense on T1-weighted images and hypointense or hyperintense on T2-weighted images. Immunohistochemical staining revealed @entity2 kinase was negative in 11 of 13 cases tested. One @entity0 quit treatment  for the unresectable mass after biopsy and died 2  years later, and another @entity0 with incompletely resection is alive at 30  months following chemotherapy. The remaining 21 cases had complete resections; one @entity0 died due to a recurrence, and the other 20 @entity0 survived and were @entity1 free. The follow-up ranged from 7 to 141  months, with a mean of 56  months. The 3-year OS was 88  % (95  % CI, 57-97  %). CONCLUSIONS: @entity1 is a benign @entity1 that rarely presents with malignant features. Complete resection is curative in most @entity0 . ALK+ is variable for diagnosis. Close follow-up is necessary for @entity0 who undergo surgical resection.

title: Analysis of clinical features and outcomes for inflammatory XXXX in China: 11 years of experience at a single center.

answer: @entity1


abstract: UNASSIGNED: A major drawback with @entity0 chemotherapy is its severe toxic effects on non-target tissues. Assessment of natural products for their protective effect against anticancer drugs-induced @entity2 is gaining importance in @entity0 biology. The present study was aimed at assessing the protective effect of @entity5 ( @entity5 ) against @entity3 ( @entity4 )-induced genotoxicity and @entity2 . Swiss albino @entity1 were injected with various doses of @entity5 (100, 200, 300, 400, 600 and 800  mg/kg b. wt., i.p) 1  h prior to @entity4 (8  mg/kg, i.p.) injection. The geno- and cyto- @entity2 were evaluated in @entity1 by performing bone marrow micronucleus and TUNEL assays. In vitro antioxidant and lipid peroxidation inhibitory assays were carried out to understand the mechanism of the protective effects. The significant increase in the frequency of micronculeated cells (12.51      0.48), apoptotic cells (23.43      1.86) and reduction in P/N ratio (0.69      0.04) compared with control indicated the potential geno- and cytotoxic effects of @entity4 in bone marrow. Pretreatment with @entity5 resulted in the significant recovery of the toxic effects induced by @entity4 . @entity5 at 400  mg/kg  b. wt. was found to be the optimum dose imparting the maximum protective effects. The in vitro antioxidant and lipid peroxidation inhibitory assays suggest that the extract possesses substantial free radical scavenging activities. In conclusion, @entity5 possesses substantial geno- and cyto-protective properties against @entity4 , which could be mediated through efficient free radical scavenging and inhibitory effect on lipid peroxidation.

title: Mitigating effect of Indian propolis against XXXX induced bone marrow toxicity.

answer: @entity3


abstract: OBJECTIVE: This systematic review and meta-analysis aimed to assess the effectiveness of ultrasound-guided (USG) versus blind (landmark-guided, LMG) corticosteroid subacromial-subdeltoid bursa injection in adults with shoulder @entity1 . METHODS: The searches were performed on PubMed, Ovid MEDLINE, Ovid EMBASE, Ovid CochraneCENTRAL, Web of Science, Google Scholar, and Scopus from database inception through March 27, 2015. Studies were included trials comparing USG versus LSG injections for the treatment of adults with @entity3 . Two reviewers independently performed data extraction and appraisal of the studies. The outcome measures collected were the decreased VAS and SDQ scores, the increased shoulder function scores and shoulder abduction motion range, and the effective rate at 6 weeks after injection. RESULTS: Seven papers including 445 @entity0 were reviewed; 224 received LMG injections and 221 received USG injections. There was a statistically significant difference in favor of USG for @entity1 score [ @entity2 = 1.19, 95% CI (0.39, 1.98), P = 0.003] and SDQ score [ @entity2 = 5.01, 95% CI (1.82, 8.19), P = 0.02] at 6 weeks after injection. Also there was a statistically significant difference between the groups, with greater improvement reported of shoulder function scores [SMD = 0.89, 95% CI (0.56, 1.23), P < 0.001] and shoulder abduction motion range [ @entity2 32.69, 95% CI (14.82, 50.56), P < 0.001] in the USG group. More effective rate was also reported with USG group and the difference was statistically significant [risk ratio = 1.6, 95% CI (1.02, 2.50), P = 0.04]. CONCLUSIONS: Ultrasound-guided corticosteroid injections potentially offer a significantly greater clinical improvement over blind SASD bursitis injections in adults with shoulder @entity1 .

title: Ultrasound-guided versus blind subacromial-subdeltoid bursa injection in adults with shoulder XXXX : A systematic review and meta-analysis.

answer: @entity1


abstract: BACKGROUND: We investigated the combined impact of @entity1 and low skeletal muscle mass on cardiovascular and total mortality in an elderly Asian population. METHODS: A total of 1,485 elderly individuals (>= 65 years) from Elderly Nutrition and Health Survey in Taiwan (1999-2000) were enrolled, and their survival status was followed using data from the National Death Registry. Skeletal muscle mass index (SMMI) was calculated by dividing skeletal muscle mass (kg) by height squared (m(2)). Low skeletal muscle mass was defined as the first quartile of SMMI. @entity1 (high @entity2 plus waist circumference [HTGWC]) was defined as @entity2 >= 150mg/dL and waist circumference >= 90cm ( @entity0 ) and >= 80cm ( @entity0 ). The Cox proportional hazard model was used to evaluate the combined impact of @entity1 and low SMMI on cardiovascular and total mortality. RESULTS: During follow-up (median 9.2 years), one third (n = 493) of subjects died from any cause, of which 34% (n = 168) were cardiovascular-related. Total and cardiovascular mortality were 4.2 and 1.4 per 100 @entity0 -years, respectively. Low SMMI and HTGWC were independently associated with total mortality in @entity0 , but only low SMMI was significantly associated in @entity0 . Those with both HTGWC and low SMMI had the highest mortality risk, with the cardiovascular mortality risk increased by >6.8-fold and 3.2-fold in @entity0 and @entity0 , respectively, compared with controls having normal SMMI and TGWC. CONCLUSIONS: Elderly individuals with @entity1 and low skeletal muscle mass have higher all-cause and cardiovascular mortality risk.

title: XXXX and Low Skeletal Muscle Mass Jointly Predict Total Mortality and Cardiovascular Mortality in an Elderly Asian Population.

answer: @entity1


abstract: BACKGROUND _ AIMS: Whether perioperative blood transfusions (PBTs) negatively impact oncologic outcomes after curative resection for @entity4 remains controversial. We aimed to identify the independent predictive factors of @entity7 for curative resection of @entity4 ( @entity4 ), and to investigate the impact of @entity7 on long-term recurrence and survivals after resection. METHODS: Of 1103 @entity0 who underwent curative liver resection for @entity4 between 1999 and 2010, 285 (25.8%) @entity0 received @entity7 . Univariable and multivariable regression analyses were used to identify independent predictive factors of @entity7 . Propensity scores and Cox regression analyses were used to compare the @entity6 ( @entity6 ) and @entity6 ( @entity6 ) between @entity0 who did and did not receive @entity7 . RESULTS: Multivariable regression analysis revealed that performance status, preoperative hemoglobin, @entity2 , @entity3 , @entity1 rupture, @entity1 size, macroscopic vascular invasion, and intraoperative @entity5 were independent predictive factors of @entity7 for @entity4 resection. Propensity score matching analysis created 234 pairs of @entity0 . Before propensity matching, @entity7 was significantly associated with increased risks of @entity6 (HR: 2.455, 95% CI: 2.077-2.901, p<0.001) and @entity6 (HR: 2.018, 95% CI: 1.718-2.370, p<0.001) in the entire cohort. After propensity matching, @entity7 was not significantly associated with increased risks of @entity6 (HR: 1.229, 95% CI: 0.988-1.527, p=0.063) and @entity6 (HR: 1.188, 95% CI: 0.960-1.469, p=0.113). After adjustment for other prognostic variables in the propensity matched cohort, @entity7 was still found not to be associated with @entity6 and @entity6 after @entity4 resection. CONCLUSIONS: The present study identified that @entity7 did not influence @entity6 and @entity6 after curative resection of @entity4 .

title: Perioperative blood transfusion does not influence recurrence-free and overall survivals after curative resection for XXXX : A Propensity Score Matching Analysis.

answer: @entity4


abstract: Two hundred twenty four dairy @entity0 (6 mo to second calving) representing four breeds (169 Holstein, 24 Guernsey, 19 Jersey, 12 Brown Swiss) were used to determine effects of age, temperature-season, and breed on blood characteristics. A total of 1183 blood samples were collected by jugular venipuncture in the middle of each temperature-season. Covariate age affected blood profile except for hemoglobin, oxyhemoglobin, glutamic-oxalacetic transaminase, and albumin. Temperature-season increased or decreased all measures except enzyme @entity2 phosphokinase, total @entity2 phosphokinase, @entity1 and @entity4 . Years differed for all measures except hemoglobin and oxyhemoglobin. Except for enzyme @entity2 phosphokinase, total @entity2 phosphokinase, and @entity4 , breeds differed in other measures. There were interactions between temperature-season and year, temperature-season and breed, and year and breed. Differences among temperature-seasons were not consistent from year to year. Breed differences were not consistent from temperature-season to temperature-season for @entity1 or protein-bound @entity3 . Breed differences were not consistent from year to year for glutamic-oxaloacetic transaminase, total protein, albumin, or @entity1 .

title: Effects of age, temperature-season, and breed on blood characteristics of dairy XXXX .

answer: @entity0