abstract: BACKGROUND: Low serum @entity2 is uncommon in @entity1 ( @entity1 ), which is surprising in view of the important role of normal kidney function to regulate water and @entity2 balance. METHODS: We report 2 cases of persistent @entity3 with balance studies in Case 1. We performed measurements of dialysate @entity2 and volume output over 24 hours in a group of chronic @entity1 @entity0 . RESULTS: The low serum @entity2 concentration did not vary too much with overall fluid removal via dialysis in @entity0 1, mainly because large quantities of @entity2 were removed in the dialysate. In the 24-hour studies, a significant relationship was found between net daily @entity1 @entity2 removal and net daily dialysate volume removed (r = 0.65). There was no relationship between net daily @entity1 @entity2 removal and serum @entity2 concentration. There was a linear direct correlation between serum and dialysate @entity2 concentration (r = 0.8) as shown by others previously. CONCLUSIONS: These results suggest that the main determinant of @entity1 @entity2 loss is net dialysate ultrafiltration volume. Water loss via dialysis is necessarily associated with @entity2 loss. In order to maintain a normal serum @entity2 concentration salt intake must be proportional to the water loss induced by dialysis. The stimuli that allow dialysis @entity0 to maintain this delicate balance between water and salt intake are of considerable interest but remain undetermined.

title: XXXX in @entity1 @entity0 .

answer: @entity3


abstract: BACKGROUND: Low serum @entity2 is uncommon in @entity1 ( @entity1 ), which is surprising in view of the important role of normal kidney function to regulate water and @entity2 balance. METHODS: We report 2 cases of persistent @entity3 with balance studies in Case 1. We performed measurements of dialysate @entity2 and volume output over 24 hours in a group of chronic @entity1 @entity0 . RESULTS: The low serum @entity2 concentration did not vary too much with overall fluid removal via dialysis in @entity0 1, mainly because large quantities of @entity2 were removed in the dialysate. In the 24-hour studies, a significant relationship was found between net daily @entity1 @entity2 removal and net daily dialysate volume removed (r = 0.65). There was no relationship between net daily @entity1 @entity2 removal and serum @entity2 concentration. There was a linear direct correlation between serum and dialysate @entity2 concentration (r = 0.8) as shown by others previously. CONCLUSIONS: These results suggest that the main determinant of @entity1 @entity2 loss is net dialysate ultrafiltration volume. Water loss via dialysis is necessarily associated with @entity2 loss. In order to maintain a normal serum @entity2 concentration salt intake must be proportional to the water loss induced by dialysis. The stimuli that allow dialysis @entity0 to maintain this delicate balance between water and salt intake are of considerable interest but remain undetermined.

title: @entity3 in XXXX @entity0 .

answer: @entity1


abstract: BACKGROUND: Low serum @entity2 is uncommon in @entity1 ( @entity1 ), which is surprising in view of the important role of normal kidney function to regulate water and @entity2 balance. METHODS: We report 2 cases of persistent @entity3 with balance studies in Case 1. We performed measurements of dialysate @entity2 and volume output over 24 hours in a group of chronic @entity1 @entity0 . RESULTS: The low serum @entity2 concentration did not vary too much with overall fluid removal via dialysis in @entity0 1, mainly because large quantities of @entity2 were removed in the dialysate. In the 24-hour studies, a significant relationship was found between net daily @entity1 @entity2 removal and net daily dialysate volume removed (r = 0.65). There was no relationship between net daily @entity1 @entity2 removal and serum @entity2 concentration. There was a linear direct correlation between serum and dialysate @entity2 concentration (r = 0.8) as shown by others previously. CONCLUSIONS: These results suggest that the main determinant of @entity1 @entity2 loss is net dialysate ultrafiltration volume. Water loss via dialysis is necessarily associated with @entity2 loss. In order to maintain a normal serum @entity2 concentration salt intake must be proportional to the water loss induced by dialysis. The stimuli that allow dialysis @entity0 to maintain this delicate balance between water and salt intake are of considerable interest but remain undetermined.

title: @entity3 in @entity1 XXXX .

answer: @entity0


abstract: Chinese snub-nosed monkeys belong to the genus @entity6 and are limited in distribution to six isolated mountainous areas in the temperate regions of Central and Southwest China. Compared to the other members of the subfamily Colobinae (or leaf-eating monkeys), these endangered primates are unique in being adapted to a high altitude environment and display a remarkable ability to tolerate low temperatures and @entity2 . They thus offer an interesting organismal model of adaptation to extreme environmental stress. Mitochondria generate energy by oxidative phosphorylation (OXPHOS) and play important roles in @entity1 usage and energy metabolism. We analyzed the mitochondrial genomes of two Chinese snub-nosed monkey species and eight other colobines in the first attempt to understand the genetic basis of high altitude adaptation in non- @entity0 primates. We found significant evidence of positive selection in one Chinese snub-nosed monkey, @entity6 , which is suggestive of adaptive change related to high altitude and cold weather stress. In addition, our study identified two potentially important adaptive @entity3 residues (533 and 3307) in the NADH2 and @entity4 6 genes, respectively. Surprisingly, no evidence for positive selection was found in @entity5 (the other Chinese snub-nosed monkey analyzed). This finding is intriguing, especially considering that @entity5 inhabits a higher altitudinal distribution than @entity6 . We hypothesize that a different adaptive genetic basis to high altitude survival exists in @entity5 from those seen in other mammals, and that positive selection and functionally associated mutations in this species may be detected in nuclear genes related to energy and @entity1 metabolism. More information on the structure, function, and evolution of mitochondrial and nuclear genomes in Chinese snub-nosed monkeys is required to reveal the molecular mechanisms that underlie adaptations to high altitude survival in non- @entity0 primates.

title: Mitogenomic analysis of Chinese snub-nosed monkeys: Evidence of positive selection in XXXX dehydrogenase genes in high-altitude adaptation.

answer: @entity4


abstract: We report a case of @entity4 with extracranial @entity1 in a 22-year-old female. The @entity0 originally presented with @entity3 and @entity6 . Neuroimaging revealed a large solid and cystic right fronto-temporal lesion. It was located completely extraventricularly and a @entity5 was suspected based on the neuroimaging findings. A gross total resection was achieved. Histopathologic examination revealed an @entity4 . The @entity0 was treated with radiotherapy. Approximately 1  year after the initial surgery, the @entity0 presented with metastatic disease to the scalp. At 2  years, an intraparotid @entity1 was detected. Subsequent neck dissection revealed positive lymph nodes at several levels. It was followed by radiotherapy to the neck. 5  years after the initial surgery, the @entity0 has residual metastatic disease. The case is discussed and the literature on extraventricular @entity2 is reviewed.

title: Extraventricular XXXX with @entity1 to scalp and neck.

answer: @entity4


abstract: We report a case of @entity4 with extracranial @entity1 in a 22-year-old female. The @entity0 originally presented with @entity3 and @entity6 . Neuroimaging revealed a large solid and cystic right fronto-temporal lesion. It was located completely extraventricularly and a @entity5 was suspected based on the neuroimaging findings. A gross total resection was achieved. Histopathologic examination revealed an @entity4 . The @entity0 was treated with radiotherapy. Approximately 1  year after the initial surgery, the @entity0 presented with metastatic disease to the scalp. At 2  years, an intraparotid @entity1 was detected. Subsequent neck dissection revealed positive lymph nodes at several levels. It was followed by radiotherapy to the neck. 5  years after the initial surgery, the @entity0 has residual metastatic disease. The case is discussed and the literature on extraventricular @entity2 is reviewed.

title: Extraventricular @entity4 with XXXX to scalp and neck.

answer: @entity1


abstract: BACKGROUND: In @entity1 -dependent @entity0 , @entity1 -associated cues elicit brain activation in mesocorticolimbic networks involved in relapse mechanisms. @entity3 ( @entity3 ) has been shown to be efficacious in the treatment of @entity2 ; however, it has remained unexplored whether @entity3 mediates its therapeutic effects via changes of activity in mesolimbic networks in response to @entity1 cues. In this study, we assessed @entity3 treatment effects on cue-induced responses using functional magnetic resonance imaging (fMRI). METHODS: In a randomized controlled trial, abstinent @entity1 -dependent @entity0 were randomly assigned to a @entity3 group (n = 15) or a control group (n = 15). All @entity0 underwent an extended detoxification treatment comprising medically supervised detoxification, health education, and supportive therapy. The @entity3 @entity0 additionally received nine @entity3 sessions over 3 weeks, exposing the @entity0 to his/her preferred alcoholic beverage. Cue-induced fMRI activation to @entity1 cues was measured at pretreatment and posttreatment. RESULTS: Compared with pretreatment, fMRI cue-reactivity reduction was greater in the @entity3 relative to the control group, especially in the anterior cingulate gyrus and the insula, as well as limbic and frontal regions. Before treatment, increased cue-induced fMRI activation was found in limbic and reward-related brain regions and in visual areas. After treatment, the @entity3 group showed less activation than the control group in the left ventral striatum. CONCLUSIONS: The study provides first evidence that an exposure-based psychotherapeutic intervention in the treatment of @entity2 impacts on brain areas relevant for addiction memory and attentional focus to @entity1 -associated cues and affects mesocorticolimbic reward pathways suggested to be pathophysiologically involved in addiction.

title: Effects of cue-exposure treatment on neural cue reactivity in XXXX dependence: a randomized trial.

answer: @entity1


abstract: PURPOSE: To study the efficacy of @entity4 in the treatment of periocular @entity6 ( @entity6 ). DESIGN: Retrospective interventional case series. @entity0 : Eighteen @entity0 presenting periocular @entity7 with occlusion of the pupil, anisometropic @entity3 , proliferating eyelid @entity7 , or cosmetically disfiguring periocular @entity7 . METHODS: All @entity0 received treatment with @entity4 started at 0.5 mg/kg/day with an incremental increase by 0.5 mg/kg/day every 4 days, up to a maximum of 2 to 3 mg/kg/day. @entity2 and serial photographs were obtained before, during, and after treatment. Doppler ultrasound and magnetic resonance imaging performed pre- and post-treatment were compared when available. MAIN OUTCOME MEASURES: Evolution of the treated @entity7 was evaluated with respect to @entity3 , @entity5 , and size of the lesion. RESULTS: The @entity7 size decreased in 17 of 18 @entity0 . We noted a greater reduction when treatment was administered during the proliferative phase of growth of @entity6 . At the conclusion of treatment, none of our @entity0 had @entity5 . The mean value of amblyogenic @entity3 (n = 7) decreased from 2.71 diopters (D) pretreatment to 1.03 D post-treatment. On radiology, 8 @entity0 had significant regression of the lesion size of their @entity7 and 1 @entity0 had a limited progression. @entity4 had to be temporarily discontinued in only 1 @entity0 because of symptomatic @entity1 . CONCLUSIONS: @entity4 seems to be an effective modality of treatment for periocular @entity7 . It seems to be most efficacious when initiated in the proliferative phase of @entity7 but may be beneficial even in the later stage. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

title: Treatment of periocular @entity6 with XXXX : case series of 18 @entity0 .

answer: @entity4


abstract: PURPOSE: To study the efficacy of @entity4 in the treatment of periocular @entity6 ( @entity6 ). DESIGN: Retrospective interventional case series. @entity0 : Eighteen @entity0 presenting periocular @entity7 with occlusion of the pupil, anisometropic @entity3 , proliferating eyelid @entity7 , or cosmetically disfiguring periocular @entity7 . METHODS: All @entity0 received treatment with @entity4 started at 0.5 mg/kg/day with an incremental increase by 0.5 mg/kg/day every 4 days, up to a maximum of 2 to 3 mg/kg/day. @entity2 and serial photographs were obtained before, during, and after treatment. Doppler ultrasound and magnetic resonance imaging performed pre- and post-treatment were compared when available. MAIN OUTCOME MEASURES: Evolution of the treated @entity7 was evaluated with respect to @entity3 , @entity5 , and size of the lesion. RESULTS: The @entity7 size decreased in 17 of 18 @entity0 . We noted a greater reduction when treatment was administered during the proliferative phase of growth of @entity6 . At the conclusion of treatment, none of our @entity0 had @entity5 . The mean value of amblyogenic @entity3 (n = 7) decreased from 2.71 diopters (D) pretreatment to 1.03 D post-treatment. On radiology, 8 @entity0 had significant regression of the lesion size of their @entity7 and 1 @entity0 had a limited progression. @entity4 had to be temporarily discontinued in only 1 @entity0 because of symptomatic @entity1 . CONCLUSIONS: @entity4 seems to be an effective modality of treatment for periocular @entity7 . It seems to be most efficacious when initiated in the proliferative phase of @entity7 but may be beneficial even in the later stage. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

title: Treatment of periocular XXXX with @entity4 : case series of 18 @entity0 .

answer: @entity6


abstract: PURPOSE: To study the efficacy of @entity4 in the treatment of periocular @entity6 ( @entity6 ). DESIGN: Retrospective interventional case series. @entity0 : Eighteen @entity0 presenting periocular @entity7 with occlusion of the pupil, anisometropic @entity3 , proliferating eyelid @entity7 , or cosmetically disfiguring periocular @entity7 . METHODS: All @entity0 received treatment with @entity4 started at 0.5 mg/kg/day with an incremental increase by 0.5 mg/kg/day every 4 days, up to a maximum of 2 to 3 mg/kg/day. @entity2 and serial photographs were obtained before, during, and after treatment. Doppler ultrasound and magnetic resonance imaging performed pre- and post-treatment were compared when available. MAIN OUTCOME MEASURES: Evolution of the treated @entity7 was evaluated with respect to @entity3 , @entity5 , and size of the lesion. RESULTS: The @entity7 size decreased in 17 of 18 @entity0 . We noted a greater reduction when treatment was administered during the proliferative phase of growth of @entity6 . At the conclusion of treatment, none of our @entity0 had @entity5 . The mean value of amblyogenic @entity3 (n = 7) decreased from 2.71 diopters (D) pretreatment to 1.03 D post-treatment. On radiology, 8 @entity0 had significant regression of the lesion size of their @entity7 and 1 @entity0 had a limited progression. @entity4 had to be temporarily discontinued in only 1 @entity0 because of symptomatic @entity1 . CONCLUSIONS: @entity4 seems to be an effective modality of treatment for periocular @entity7 . It seems to be most efficacious when initiated in the proliferative phase of @entity7 but may be beneficial even in the later stage. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

title: Treatment of periocular @entity6 with @entity4 : case series of 18 XXXX .

answer: @entity0


abstract: The distribution pattern and associated tissue reactions with progressive changes in Besnoitia caprae cysts were investigated in 6 experimentally infected 16- to 20-month-old male @entity2 . Each @entity2 was subcutaneously inoculated with approximately 13   10(8) B caprae bradyzoites. The animals were examined daily for development of clinical @entity3 , and skin biopsies from distal parts of the limbs were taken at weekly intervals. At 15, 30, 60, 120, 180, and 365 days postinfection (DPI), 1 @entity2 was euthanized. Samples were collected at autopsy from various organs for histologic and ultrastructural studies. No cysts were seen in tissue sections on 15, 30, and 365 DPI, but large numbers were present at 60, 120, and 180 DPI in the skin of the distal limbs, scrotum, and ears, with fewer in the tongue, palate, sclera, testicles, and spermatic cord. No cysts were seen in the lungs, liver, kidneys, @entity0 , or lymph nodes. Cyst numbers peaked at 60 DPI, then declined from 120 to 180 DPI. @entity1 were relatively rare at 60 DPI but more numerous at 180 compared with 120. A granulomatous reaction--predominantly characterized by macrophages, lymphocytes, and plasma cells--surrounded each degenerated cyst. All @entity2 showed testicular tubular degeneration with little or no spermatogenic activity. The sizes of cysts and their wall thickness, with the size of bradyzoites and some of their organelles, exhibited progressive chronologic changes.

title: Histopathologic and ultrastructural studies on experimental caprine XXXX .

answer: @entity3


abstract: @entity3 ( @entity3 ) is the most common @entity2 of the gastrointestinal tract. It can be benign or malignant in behavior. Stomach, being the most common site (70%) for GISTs, is followed by the small intestine (20%). Anorectal, colonic, and esophageal GISTs are uncommon, whereas extraintestinal GISTs are extremely rare. The presenting symptoms are highly dependent on @entity1 size and location, although a large number of GISTs are asymptomatic. The purpose of this article is to highlight the unusual characteristics of GISTs illustrated by PET/CT and CT imaging. These characteristics are organized into (1) @entity1 location, (2) unusual clinical presentation, and (3) unusual sites of @entity0 . Knowing the uncommon features of GISTs is important, as they are more often seen nowadays with the increasingly important role of PET/CT and CT in @entity3 management; and these @entity1 are associated with a poorer prognosis and unwanted delay in diagnosis is avoidable. With the availability of effective treatment by @entity4 , a prompt and early diagnosis is essential for disease control. All GISTs illustrated in this article are pathologically proven.

title: Unusual features of XXXX on PET/CT and CT imaging.

answer: @entity3


abstract: OBJECTIVE:     To study the operability and effectiveness of a biodegradable ureteral stent for clinical treatment of @entity1 using a @entity0 model. MATERIALS AND METHODS:     A device was designed and employed to generate firearm fragment wounds in unilateral ureters (on randomly chosen sides) of nine beagles (Group A). The wounded ureters were then debrided and sutured.     Intravenous pyelography (IVP) and radioactive renography were performed 40, 80 and 120 days postoperatively. In Group B, firearm fragment wounds were made to the bilateral ureters in nine beagles. A @entity3 stent was placed unilaterally (on a randomly chosen side) whereas the ureter on the other side was debrided and sutured without stenting.     Both IVP and radioactive renography were performed 40, 80 and 120 days postoperatively. The operability and effectiveness of the biodegradable ureteral stent were studied thereafter. RESULTS:     In Group A, @entity2 and hydroureter occurred and worsened postoperatively on the wounded sides in all nine beagles. The ratio of the renal partial concentration indices (RPCI) between the kidneys (unwounded side : wounded side) increased.     The ratio of the kidney washout half-time between the kidneys (unwounded side : wounded side) decreased. In Group B, neither @entity2 nor hydroureter was found postoperatively in the stented ureters but both occurred in the unstented ureters in all nine beagles.     The ratio of RPCI between kidneys (stented side : unstented side) increased whereas the kidney washout half-time ratio between the stented and unstented sides decreased. Differences were significant. CONCLUSION:     In Group A, the new @entity0 model for firearm fragment wounds was tested and proved to be operable and effective. In Group B, @entity2 and hydroureter were effectively prevented in ureters by biodegradable stent placement compared with the non-stented ureters where @entity2 and hydroureter occurred. The renal concentration capacity was effectively protected and the half-time of kidney washout was shortened.

title: Introduction to biodegradable @entity3 ureteral stent application for treatment of XXXX .

answer: @entity1


abstract: OBJECTIVE:     To study the operability and effectiveness of a biodegradable ureteral stent for clinical treatment of @entity1 using a @entity0 model. MATERIALS AND METHODS:     A device was designed and employed to generate firearm fragment wounds in unilateral ureters (on randomly chosen sides) of nine beagles (Group A). The wounded ureters were then debrided and sutured.     Intravenous pyelography (IVP) and radioactive renography were performed 40, 80 and 120 days postoperatively. In Group B, firearm fragment wounds were made to the bilateral ureters in nine beagles. A @entity3 stent was placed unilaterally (on a randomly chosen side) whereas the ureter on the other side was debrided and sutured without stenting.     Both IVP and radioactive renography were performed 40, 80 and 120 days postoperatively. The operability and effectiveness of the biodegradable ureteral stent were studied thereafter. RESULTS:     In Group A, @entity2 and hydroureter occurred and worsened postoperatively on the wounded sides in all nine beagles. The ratio of the renal partial concentration indices (RPCI) between the kidneys (unwounded side : wounded side) increased.     The ratio of the kidney washout half-time between the kidneys (unwounded side : wounded side) decreased. In Group B, neither @entity2 nor hydroureter was found postoperatively in the stented ureters but both occurred in the unstented ureters in all nine beagles.     The ratio of RPCI between kidneys (stented side : unstented side) increased whereas the kidney washout half-time ratio between the stented and unstented sides decreased. Differences were significant. CONCLUSION:     In Group A, the new @entity0 model for firearm fragment wounds was tested and proved to be operable and effective. In Group B, @entity2 and hydroureter were effectively prevented in ureters by biodegradable stent placement compared with the non-stented ureters where @entity2 and hydroureter occurred. The renal concentration capacity was effectively protected and the half-time of kidney washout was shortened.

title: Introduction to biodegradable XXXX ureteral stent application for treatment of @entity1 .

answer: @entity3


abstract: BACKGROUND: Although smokers tend to have a lower body-mass index than non-smokers, smoking may favour abdominal body fat accumulation. To our knowledge, no population-based studies have assessed the relationship between smoking and body fat composition. We assessed the association between cigarette smoking and waist circumference, body fat, and body-mass index. METHODS: Height, weight, and waist circumference were measured among 6,123 Caucasians (ages 35-75) from a cross-sectional population-based study in Switzerland. @entity1 was defined as waist circumference >=  102 cm for @entity0 and >=  88 cm for @entity0 . Body fat (percent total body weight) was measured by electrical bioimpedance. Age- and sex-specific body fat cut-offs were used to define excess body fat. Cigarettes smoked per day were assessed by self-administered questionnaire. Age-adjusted means and odds ratios were calculated using linear and logistic regression. RESULTS: Current smokers (29% of @entity0 and 24% of @entity0 ) had lower mean waist circumference, body fat percentage, and body-mass index compared with non-smokers. Age-adjusted mean waist circumference and body fat increased with cigarettes smoked per day among smokers. The association between cigarettes smoked per day and body-mass index was non-significant. Compared with light smokers, the adjusted odds ratio (OR) for @entity1 in @entity0 was 1.28 (0.78-2.10) for moderate smokers and 1.94 (1.15-3.27) for heavy smokers (P = 0.03 for trend), and 1.07 (0.72-1.58) and 2.15 (1.26-3.64) in female moderate and heavy smokers, respectively (P < 0.01 for trend). Compared with light smokers, the OR for excess body fat in @entity0 was 1.05 (95% CI: 0.58-1.92) for moderate smokers and 1.15 (0.60-2.20) for heavy smokers (P = 0.75 for trend) and 1.34 (0.89-2.00) and 2.11 (1.25-3.57), respectively in @entity0 (P = 0.07 for trend). CONCLUSION: Among smokers, cigarettes smoked per day were positively associated with central fat accumulation, particularly in @entity0 .

title: Dose-dependent positive association between cigarette smoking, XXXX and body fat: cross-sectional data from a population-based survey.

answer: @entity1


abstract: BACKGROUND: Genetically unreduced (2n) @entity2 ( @entity2 ) form in ovules of gametophytic apomicts, the 2n eggs of which develop into embryos parthenogenetically. In many apomicts, 2n @entity2 form precociously during ovule development. Whether meiosis and @entity0 also occur precociously in facultative apomicts (capable of apomictic and sexual reproduction) has not been studied. We determined onset timing of meiosis and @entity0 for 569 @entity1 genotypes, many of which produced 2n @entity2 facultatively. RESULTS: Genotype differences for onset timing of meiosis and @entity0 , relative to ovule development, were highly significant. A major source of variation in timing of sexual germline development was presence or absence of apomictic @entity2 , which formed from nucellar cells (apospory) in some genotypes. Genotypes that produced these aposporous @entity2 underwent meiosis and @entity0 precociously. Aposporous @entity2 formation was most prevalent in subsp. verticilliflorum and in breeding lines of subsp. bicolor. It was uncommon in land races. CONCLUSIONS: The present study adds meiosis and @entity0 to floral induction, apomictic @entity2 formation, and parthenogenesis as processes observed to occur precociously in apomictic plants. The temporally diverse nature of these events suggests that an epigenetic memory of the plants' apomixis status exists throughout its life cycle, which triggers, during multiple life cycle phases, temporally distinct processes that accelerate reproduction.

title: Apospory appears to accelerate onset of meiosis and sexual embryo sac formation in XXXX ovules.

answer: @entity1


abstract: BACKGROUND: Indo-Asians in Canada are at increased risk for @entity1 . There is a need for cultural and language specific educational materials relating to this risk. During this project we developed and field tested the acceptability of a @entity2 public education pamphlet tailored to fit the needs of an at risk local Indo-Asian population, in Calgary, Alberta, Canada. METHODS: A community health board representing Calgary's Indo-Asian communities identified the culturally specific educational needs and language preferences of the local population. An adaptation of an existing English language Canadian Public Hypertension Recommendations pamphlet was created considering the literacy and translation challenges. The adapted pamphlet was translated into four Indo-Asian languages. The adapted pamphlets were disseminated as part of the initial educational component of a community-based culturally and language-sensitive @entity1 factor screening and management program. Field testing of the materials was undertaken when @entity0 returned for program follow-up seven to 12 months later. RESULTS: Fifty-nine English-speaking @entity0 evaluated and confirmed the concept validity of the English adapted version. 28 non-English speaking @entity0 evaluated the Gujarati (N = 13) and Punjabi (N = 15) translated versions of the adapted pamphlets. All @entity0 found the pamphlets acceptable and felt they had improved their understanding of @entity2 . CONCLUSIONS: Involving the target community to identify health issues as well as help to create culturally, language and literacy sensitive health education materials ensures resources are highly acceptable to that community. Minor changes to the materials will be needed prior to formal testing of @entity2 knowledge and health decision-making on a larger scale within this at risk community.

title: Tackling health literacy: adaptation of public XXXX educational materials for an Indo-Asian population in Canada.

answer: @entity2


abstract: OBJECTIVE: To analyze the different success rates of air enema in intussusception cases at different ages and evaluate the value of plain film in assessing the pathogenetic condition of intussusception and intussusception with vascular compromise in @entity0 . METHODS: A retrospective analysis was performed on the success rates of air enema in 1119 pediatric cases of intussusception at different ages. The radiographic findings of 190 cases were analyzed. Air enema reduction failed in 95 cases. And 95 control cases were randomly selected for reduction by air enema. Their operative and pathological data were analyzed and compared with the findings of plain film. @entity2 was analyzed by a comparison of plain film and pathology. The plain films of @entity0 were analyzed by two experienced radiologist independently. Whenever there was dissension, they discussed and reached an agreement. RESULTS: In all cases of intussusception, the successful reduction rate was 91.5%. The cases within 1-year-old were 627 cases, air enema success rate was 87.1% and the success rate of air enema was 97.2% in beyond 1-year-old group. There was significant difference between two groups (  (2) = 36.01, P < 0.01). In 95 cases of failed air enema reduction, 14 cases were ileoileal, 10 ileocaecal and 25 ileocolic. And 44 cases were ileoilealcolic and 2 ileocoliccolic. Eleven cases had @entity1 . Four cases had small bowel duplication cyst and 3 with Meckel's diverticulum. @entity2 in plain film had a high concordance with pathology (kappa = 0.7128). The pathology type was somewhat correlated with the finding of plain film (P < 0.01). As assessed by plain film, there were intussusceptions with vascular compromise (n = 30) with a coffee-bean sign or banana sign, a paucity of bowel gas (n = 36), quadrant gas (n = 51) and mass or crescent (n = 73). Through an analysis between plain film signs and the onset of symptom by Spearman correlation (nonzero correlation = 20.67, P < 0.01), there was statistical significance. CONCLUSION: The successful rate of air enema in intussusception is lower in within 1-year-old group than beyond 1-year-old group. The sign of plain film is more significant in assessing the pathogenetic conditions of intussusception. And it has a high concordance with pathology in assessing the @entity2 .

title: [Analyses of air enema and radiographic film for acute intussusception in XXXX ].

answer: @entity0


abstract: OBJECTIVE: To study the protective effects of @entity4 ( @entity3 ) on the Ab(25-35)-induced apoptosis in PC-12 cells. METHODS: The apoptosis of PC-12 cell was analyzed by @entity1 assay, transmission electron microscope and PI method at different concentrations of @entity3 (0.1, 1.0, 10, 100   mol/L) with the addition of Ab or not. The expressions of @entity2 and cytochrome C (Cyt-C) were detected by Western blot. RESULTS: As demonstrated by the @entity1 assay, the values of cell viability were 76.5%    1.1%, 84.2%    1.3%, 89.5%    1.3% and 81.9%    1.9% at various concentration (0.1, 1.0, 10, 100   mol/L) of @entity3 respectively. The model group was 71.7%    1.4%. It was revealed that the former could significantly prevent the cell viability under the induction of Ab(25-35) (P < 0.05). A pretreatment with 10   mol/L @entity3 could significantly inhibit the decrease of viability under the induction of Ab(25-35) (P < 0.05). PI showed that the apoptosis rate of the 10   mol/L @entity3 treatment group was significantly lower than that of the model group. Under electron microscope, the characteristics of cell apoptosis were significant in the model group. And the cell morphology of the 10   mol/L @entity3 treatment group was normal. The expression rate of @entity2 protein in the 10   mol/L @entity3 treatment group was obviously higher than that in the model group. @entity0 was weakly expressed in nerve cells of the normal and the 10   mol/L @entity3 groups. But it had a strong expression in the model group. CONCLUSION: @entity3 prevents the injury of PC12 cells by Ab. And the mechanism may be related to the elevated level of @entity2 and the inhibited mitochondrial release of Cyt-C.

title: [Effects of XXXX on the apoptosis of PC-12 cells under the induction of b-amyloid peptide].

answer: @entity4


abstract: A prospective open-label study was designed to determine the efficacy and safety of continuous @entity9 infusion in neonates with uncontrollable neonatal @entity2 . @entity0 whose @entity2 could not be controlled by @entity12 , @entity11 or @entity1 were enrolled. @entity9 was given as an intravenous bolus dose followed by continuous intravenous infusion. Thirty-two @entity0 fulfilled the inclusion criteria. @entity9 terminated the @entity2 in all @entity0 . The maximum dose of @entity9 ranged from 1 microgram/kg/min to 15 micrograms/kg/min, with average of 4 micrograms/kg/min. Four @entity0 had recurrent @entity2 , which stop after @entity9 was reinstituted. There were no significant changes in serum @entity10 , @entity8 , @entity5 or @entity3 in any of the @entity0 . Adverse effects included @entity6 in 12 @entity0 (38%) that was successfully controlled with intropic agents ( @entity7 and/or @entity4 ) and transient urinary retention in 12 (38%). Our study suggests that @entity9 is safe and effective for the treatment of uncontrollable neonatal @entity2 .

title: Continuous @entity9 infusion in the treatment of uncontrollable neonatal XXXX .

answer: @entity2


abstract: A prospective open-label study was designed to determine the efficacy and safety of continuous @entity9 infusion in neonates with uncontrollable neonatal @entity2 . @entity0 whose @entity2 could not be controlled by @entity12 , @entity11 or @entity1 were enrolled. @entity9 was given as an intravenous bolus dose followed by continuous intravenous infusion. Thirty-two @entity0 fulfilled the inclusion criteria. @entity9 terminated the @entity2 in all @entity0 . The maximum dose of @entity9 ranged from 1 microgram/kg/min to 15 micrograms/kg/min, with average of 4 micrograms/kg/min. Four @entity0 had recurrent @entity2 , which stop after @entity9 was reinstituted. There were no significant changes in serum @entity10 , @entity8 , @entity5 or @entity3 in any of the @entity0 . Adverse effects included @entity6 in 12 @entity0 (38%) that was successfully controlled with intropic agents ( @entity7 and/or @entity4 ) and transient urinary retention in 12 (38%). Our study suggests that @entity9 is safe and effective for the treatment of uncontrollable neonatal @entity2 .

title: Continuous XXXX infusion in the treatment of uncontrollable neonatal @entity2 .

answer: @entity9


abstract: BACKGROUND: Painful @entity7 or @entity3 can be an important signal for @entity4 and progression to @entity6 due to intraarticular pathology. However, there is limited literature discussing the use of arthroscopy for the treatment of @entity2 hip. The purpose of this retrospective study was to analyze the effectiveness and benefit of arthroscopic treatment for @entity0 with a @entity2 hip after @entity1 . METHODS: From July 2003 to February 2013, we reviewed 13 @entity0 who underwent arthroscopic treatment after @entity3 or @entity7 and were followed up for a minimum of 2 postoperative years. The degree of @entity6 based on the Tonnis classification pre- and postoperatively at final follow-up was determined. Clinical outcomes were evaluated using visual analogue scale for @entity2 (VAS) and modified Harris hip score (MHHS), and range of motion (ROM) of the hip pre- and postoperatively at final follow-up. RESULTS: There were nine male and four female @entity0 with a mean age at surgery of 28 years (range, 20 to 50 years). The mean follow-up period of the @entity0 was 59.8 months (range, 24 to 115 months), and the mean interval between initial @entity1 and arthroscopic treatment was 40.8 months (range, 1 to 144 months). At the final follow-up, VAS and MHHS improved significantly from 6.3 and 53.4 to 3.0 and 88.3, respectively (p = 0.002 and p < 0.001, respectively). However, there were no significant differences in hip flexion, abduction, adduction, external rotation, and internal rotation as minor improvements from 113.1  , 38.5  , 28.5  , 36.5  , and 22.7   to 118.5  , 39.0  , 29.2  , 38.9  , and 26.5   were observed, respectively (p = 0.070, p = 0.414, p = 0.317, p = 0.084, and p = 0.136, respectively). None of the @entity0 exhibited progression of @entity5 at the final follow-up. CONCLUSIONS: Arthroscopic treatment after @entity3 or @entity7 is effective and delays the progression of @entity1 .

title: Usefulness of Arthroscopic Treatment of Painful Hip after Acetabular Fracture or XXXX .

answer: @entity7


abstract: BACKGROUND: It has been proposed that Fas- @entity2 interaction was responsible for the apoptosis of epidermal cells in @entity6 ( @entity6 ) and @entity3 ( @entity3 ) and that high doses of intravenous immunoglobulin (IVIG) could help @entity0 by blocking the apoptosis. OBJECTIVE: To study the effects of IVIG on @entity6 and @entity3 . DESIGN: Prospective open trial. SETTING: Referral center of a university hospital. @entity0 : Thirty-four consecutive @entity0 admitted for @entity6 (n = 9), @entity6 (n = 5), or @entity3 (n = 20) a mean of 4.3 days after onset. INTERVENTION: A dose of 2 g/kg of IVIG was administered within 2 days (half doses or full doses over a longer period for @entity0 with low @entity5 clearance). MAIN OUTCOME MEASURES: Detached plus detachable proportions of the total body surface area measured before and after treatment and predicted @entity4 rate estimated on admission with a validated prognostic score. RESULTS: Epidermal detachment involved a mean +/- SD 19% +/- 16% of the total body surface area on admission and 32% +/- 26% after IVIG treatment (progression in 22 of 34 cases, including most @entity0 referred early). The prognostic score predicted 8.2 @entity4 (24%); 11 were observed (32%; 95% confidence interval, 17%-51%). Most @entity4 occurred in elderly @entity0 who had initially @entity1 . CONCLUSIONS: The confidence interval of the observed @entity4 rate excludes a dramatic decrease in mortality. No measurable effect was observed on the progression of detachment or on the speed of reepidermalization. These results do not support the routine use of IVIG treatment for @entity0 with @entity6 or @entity3 , especially in cases of @entity1 .

title: Intravenous immunoglobulin treatment for @entity6 and XXXX : a prospective noncomparative study showing no benefit on mortality or progression.

answer: @entity3


abstract: BACKGROUND: It has been proposed that Fas- @entity2 interaction was responsible for the apoptosis of epidermal cells in @entity6 ( @entity6 ) and @entity3 ( @entity3 ) and that high doses of intravenous immunoglobulin (IVIG) could help @entity0 by blocking the apoptosis. OBJECTIVE: To study the effects of IVIG on @entity6 and @entity3 . DESIGN: Prospective open trial. SETTING: Referral center of a university hospital. @entity0 : Thirty-four consecutive @entity0 admitted for @entity6 (n = 9), @entity6 (n = 5), or @entity3 (n = 20) a mean of 4.3 days after onset. INTERVENTION: A dose of 2 g/kg of IVIG was administered within 2 days (half doses or full doses over a longer period for @entity0 with low @entity5 clearance). MAIN OUTCOME MEASURES: Detached plus detachable proportions of the total body surface area measured before and after treatment and predicted @entity4 rate estimated on admission with a validated prognostic score. RESULTS: Epidermal detachment involved a mean +/- SD 19% +/- 16% of the total body surface area on admission and 32% +/- 26% after IVIG treatment (progression in 22 of 34 cases, including most @entity0 referred early). The prognostic score predicted 8.2 @entity4 (24%); 11 were observed (32%; 95% confidence interval, 17%-51%). Most @entity4 occurred in elderly @entity0 who had initially @entity1 . CONCLUSIONS: The confidence interval of the observed @entity4 rate excludes a dramatic decrease in mortality. No measurable effect was observed on the progression of detachment or on the speed of reepidermalization. These results do not support the routine use of IVIG treatment for @entity0 with @entity6 or @entity3 , especially in cases of @entity1 .

title: Intravenous immunoglobulin treatment for XXXX and @entity3 : a prospective noncomparative study showing no benefit on mortality or progression.

answer: @entity6


abstract: Long-term monolayer cultures of adult @entity0 hepatocytes were tested for their ability to glucuronize @entity4 red and to maintain initial levels of cell proteins, @entity1 consumption, and @entity3 production. @entity3 dehydrogenase leakage served as an index of culture status because a high value indicates cell death. Three tissue culture (TC) media formulations were the main variables introduced to determine ideal conditions for cell survival in vitro. Investigations of long-term cultures were preceded by studies of hepatocyte attachment to @entity2 surfaces. This attachment was influenced by the amount of substrate deposited and the number of cells seeded, but not by the uniformity of the substrate coating. A statistical analysis of our data revealed that in the absence of fetal bovine serum (FBS), air dried collagen (ADC) and Biomatrix (BMX) were superior to saline precipitated collagen and fibronectin as attachment substrates. In the presence of 10% FBS, all of the substrates performed equally. Chee's Medium (CEM) proved to be the best for preserving cell proteins over a time course of 28 d and Williams' E medium also performed adequately up to 14 d. The glucuronization of @entity4 red was at 50% of initial values at Day 7 in CEM-ADC hepatocytes in contrast to 30% for cells in Williams' E medium and 5% for cells grown in Waymouth's. At 14 d glucuronization was still present at 40% of original values in CEM-ADC cells but had ceased in the other two media. When BMX was used, none of the TC media supported glucuronization levels comparable to ADC cells.

title: Attachment and long term survival of adult XXXX hepatocytes in primary monolayer cultures: comparison of different substrata and tissue culture media formulations.

answer: @entity0


abstract: Purpose. @entity2 ( @entity2 ) plays a crucial role in both adaptive and innate immunity. The @entity7 gene polymorphism of @entity2 is associated with various @entity3 , like @entity1 . Methods. 134 @entity0 with @entity4 positive @entity6 , 84 @entity0 with intermediate @entity5 , 132 controls, and 65 @entity4 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for @entity7 was significantly higher in @entity0 with intermediate @entity5 compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11). Frequencies of the minor allele for @entity7 did not differ significantly in @entity0 with @entity4 associated @entity5 when compared to controls (p > 0.05). Conclusion. These findings further deepen our understanding of the commonality between @entity1 and intermediate @entity5 . Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.

title: Analysis of a Functional @entity2 Gene Polymorphism in @entity4 Associated and Intermediate XXXX Gives New Insight in Disease Pathogenesis and Commonality with Other @entity3 .

answer: @entity5


abstract: Purpose. @entity2 ( @entity2 ) plays a crucial role in both adaptive and innate immunity. The @entity7 gene polymorphism of @entity2 is associated with various @entity3 , like @entity1 . Methods. 134 @entity0 with @entity4 positive @entity6 , 84 @entity0 with intermediate @entity5 , 132 controls, and 65 @entity4 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for @entity7 was significantly higher in @entity0 with intermediate @entity5 compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11). Frequencies of the minor allele for @entity7 did not differ significantly in @entity0 with @entity4 associated @entity5 when compared to controls (p > 0.05). Conclusion. These findings further deepen our understanding of the commonality between @entity1 and intermediate @entity5 . Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.

title: Analysis of a Functional @entity2 Gene Polymorphism in @entity4 Associated and Intermediate @entity5 Gives New Insight in Disease Pathogenesis and Commonality with Other XXXX .

answer: @entity3


abstract: Purpose. @entity2 ( @entity2 ) plays a crucial role in both adaptive and innate immunity. The @entity7 gene polymorphism of @entity2 is associated with various @entity3 , like @entity1 . Methods. 134 @entity0 with @entity4 positive @entity6 , 84 @entity0 with intermediate @entity5 , 132 controls, and 65 @entity4 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for @entity7 was significantly higher in @entity0 with intermediate @entity5 compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11). Frequencies of the minor allele for @entity7 did not differ significantly in @entity0 with @entity4 associated @entity5 when compared to controls (p > 0.05). Conclusion. These findings further deepen our understanding of the commonality between @entity1 and intermediate @entity5 . Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.

title: Analysis of a Functional XXXX Gene Polymorphism in @entity4 Associated and Intermediate @entity5 Gives New Insight in Disease Pathogenesis and Commonality with Other @entity3 .

answer: @entity2


abstract: Purpose. @entity2 ( @entity2 ) plays a crucial role in both adaptive and innate immunity. The @entity7 gene polymorphism of @entity2 is associated with various @entity3 , like @entity1 . Methods. 134 @entity0 with @entity4 positive @entity6 , 84 @entity0 with intermediate @entity5 , 132 controls, and 65 @entity4 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. Results. The frequency of carriers of the minor allele for @entity7 was significantly higher in @entity0 with intermediate @entity5 compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11). Frequencies of the minor allele for @entity7 did not differ significantly in @entity0 with @entity4 associated @entity5 when compared to controls (p > 0.05). Conclusion. These findings further deepen our understanding of the commonality between @entity1 and intermediate @entity5 . Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.

title: Analysis of a Functional @entity2 Gene Polymorphism in XXXX Associated and Intermediate @entity5 Gives New Insight in Disease Pathogenesis and Commonality with Other @entity3 .

answer: @entity4


abstract: OBJECTIVE: To assess the effect of the introduction of a physiotherapist with an extended scope of practice in the management of acute soft tissue @entity6 in an accident and emergency (A_E) department. METHODS: The A_E department established an Acute Knee Screening Service (AKSS) in 1998. An experienced physiotherapist was appointed to run the AKSS after additional training. Local guidelines and protocols were developed in conjunction with @entity1 knee surgeons, radiologists, physiotherapists, and A_E doctors. This study describes 100 consecutive @entity0 managed by the AKSS over a three month period and comparisons are made over a similar period before the introduction of the AKSS. RESULTS: The initial diagnosis of @entity0 with @entity2 referred to the service showed @entity1 (38%), cruciate @entity1 (18%), @entity3 (2%), @entity1 (10%), and others (32%). Ninety five per cent of @entity0 referred to AKSS were seen within one week. Medical time was saved in both A_E and @entity1 clinic. Fifty nine per cent of @entity0 were treated and discharged from the service without further medical review. Thirty nine per cent (39) were referred to @entity1 clinic and of these 44% (17) had MRI scans performed as requested by the physiotherapist. Eighty eight per cent (15) of these scans showed significant abnormality: (nine, @entity5 , one, posterior cruciate ligament tears, and nine @entity4 ). CONCLUSIONS: A physiotherapy practitioner working with an extended role is a valuable addition to an A_E department. The AKSS improves the quality of care of @entity2 , saves medical time, and fosters cooperation across services within the NHS.

title: Management of soft tissue XXXX in an accident and emergency department: the effect of the introduction of a physiotherapy practitioner.

answer: @entity6


abstract: Between September 1971 and May 1982, at the University of California at Los Angeles Medical Center, 821 total knee arthroplasties were performed in 604 @entity0 , all of whom received perioperative antibiotics. @entity3 , proved by a positive culture of a specimen obtained by postoperative arthrocentesis, developed fourteen times in thirteen knees of twelve @entity0 , an incidence of 1.71 per cent. In one of these @entity0 , who had @entity4 and bilateral knee replacement, the right knee became infected with two distinct organisms on two different occasions (separated by ten months). The first infection was probably hematogenous while the second, developing after a dental procedure, definitely was. Over-all, five @entity2 were hematogenous with an identified source and one other was suspected of having a hematogenous origin. The time from operation to the diagnosis of @entity3 averaged 8.3 months over-all, but five of the fourteen @entity2 were recognized less than two months after arthroplasty. For the six @entity2 that were assumed to be hematogenous, the time from operation to the diagnosis of @entity3 averaged 16.4 months. The major presenting symptom was @entity1 in thirteen of the fourteen @entity2 . The initial treatments of the fourteen @entity2 consisted of intravenous antibiotics in all of them, primary removal of the prosthesis and so-called exchange arthroplasty after five days in one, removal of the prosthesis and fusion in one, arthrotomy and d  bridement in six, arthroscopic irrigation in three, and antibiotics alone in three (of which one was treated with an exchange arthroplasty after three weeks). At last follow-up, only four of the thirteen prostheses had been salvaged.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX following total knee arthroplasty. Ten-year experience at the University of California at Los Angeles Medical Center.

answer: @entity3


abstract: OBJECTIVES: Heart transplant is the best treatment for end-stage @entity8 . @entity13 after heart transplant is a potentially serious complication. @entity5 , @entity3 , allograft failure or rejection, and structural @entity4 in the donor heart are among the causes of @entity6 after transplant. In this study, we evaluated the prevalence of @entity6 and @entity13 in @entity0 with orthotopic heart transplant during the early postoperative period. MATERIALS AND METHODS: We retrospectively evaluated the medical records of 45 @entity0 who had received orthotopic heart transplant at our center. Clinical and demographic variables and laboratory data were noted. @entity1 saturation values from @entity0 in the first week and the first month after transplant were analyzed. We also documented the cause of @entity13 and the type of treatment. RESULTS: Mean age was 35.3    15.3 years (range, 12-61 y), with males comprising 32 of 45 @entity0 (71.1%). Two @entity0 had mild @entity11 and 1 had @entity7 . Twenty-five @entity0 (55.6%) had a history of smoking. @entity13 was noted in 9 @entity0 (20%) during the first postoperative week. Regarding cause, 5 of these @entity0 (11.1%) had @entity12 , 2 (4.4%) had @entity10 , 1 (2.2%) had @entity2 , and 1 (2.2%) had @entity9 . Therapies administered to @entity0 with @entity13 were as follows: 5 @entity0 had @entity1 therapy with nasal canula/mask, 3 @entity0 had continuous positive airway pressure, and 1 @entity0 had mechanical ventilation. One month after transplant, 2 @entity0 (4.4%) had @entity13 1 (2.2%) due to @entity12 and 1 (2.2%) due to @entity10 . CONCLUSIONS: @entity13 is a common complication in the first week after orthotopic heart transplant. Identification of the underlying cause is an important indicator for therapy. With appropriate care, @entity13 can be treated successfully.

title: Prevalence, Cause, and Treatment of XXXX After Orthotopic Heart Transplant.

answer: @entity13


abstract: The periplasmic @entity0 binding protein of pathogenic Gram-negative bacteria performs an essential role in @entity0 acquisition from transferrin and other @entity0 sources. Structural analysis of this protein from @entity1 identified four @entity6 that ligand the bound @entity0 : His(9), @entity2 (57), Tyr(195), and Tyr(196). A phosphate provides an additional ligand, and the presence of a water molecule is required to complete the octahedral geometry for stable @entity0 binding. We report the 1.14-A resolution crystal structure of the @entity0 -loaded form of the @entity1 periplasmic ferric ion binding protein (FbpA) mutant @entity7 . This protein was produced in the periplasm of @entity3 and, after purification and conversion to the apo form, was @entity0 -loaded. H9Q is able to bind ferric @entity0 in an open conformation. A surprising finding in the present high resolution structure is the presence of @entity4 located at the previously determined anion ternary binding site, where @entity5 is located in the wild type holo and apo structures. @entity4 contributes four of the six coordinating ligands for @entity0 , with two Tyr residues, 195 and 196, completing the coordination. This is the first example of a metal binding protein with a bound metal. @entity4 complex. The results suggest that FbpA may have the ability to bind and transport @entity0 bound to biological chelators, in addition to bare ferric @entity0 .

title: High resolution structure of an alternate form of the ferric ion binding protein from XXXX .

answer: @entity1


abstract: Renal hemodynamics increase dramatically during pregnancy, and pressor responsiveness to exogenous administration of vasoconstrictors is attenuated. We investigated whether or not vasodilatory @entity3 mediate these phenomena. Trained, chronically instrumented, conscious pregnant @entity0 were used. Control values of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were elevated at midgestation (P less than 0.01 and P = 0.05 from prepregnant means, respectively), and effective renal vascular resistance was decreased (P = 0.05). @entity4 (4.5-6.5 mg/kg body weight [BW]) failed to decrease renal hemodynamics at this stage of pregnancy; in fact, it raised GFR somewhat further (P less than 0.05). Systemic pressor responsiveness to bolus administration of @entity1 and @entity2 (AII) was significantly attenuated by at least gestational day 20. Neither @entity4 (7 mg/kg BW) or @entity5 (6 mg/kg BW) affected the refractory response. The renal vasculature was also relatively unresponsive to an intravenous infusion of AII (5 ng X kg-1 X min-1) during late gestation (day 19); in particular, the fall in ERPF in response to AII (16 +/- 3%) was markedly less than that observed in the prepregnant condition (34 +/- 3%; P less than 0.05). @entity4 (6 mg/kg BW) failed to restore this blunted response, and further attenuation was evident, despite the presence of the inhibitor (gestational day 21). We conclude that vasodilatory @entity3 do not appear to mediate the rise in renal hemodynamics, and the attenuation of the systemic and renal pressor responsiveness observed during pregnancy, insofar as these phenomena were unaffected by acute cyclooxygenase inhibition in unstressed, conscious @entity0 .

title: Evidence against the hypothesis that XXXX are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious @entity0 .

answer: @entity3


abstract: Renal hemodynamics increase dramatically during pregnancy, and pressor responsiveness to exogenous administration of vasoconstrictors is attenuated. We investigated whether or not vasodilatory @entity3 mediate these phenomena. Trained, chronically instrumented, conscious pregnant @entity0 were used. Control values of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were elevated at midgestation (P less than 0.01 and P = 0.05 from prepregnant means, respectively), and effective renal vascular resistance was decreased (P = 0.05). @entity4 (4.5-6.5 mg/kg body weight [BW]) failed to decrease renal hemodynamics at this stage of pregnancy; in fact, it raised GFR somewhat further (P less than 0.05). Systemic pressor responsiveness to bolus administration of @entity1 and @entity2 (AII) was significantly attenuated by at least gestational day 20. Neither @entity4 (7 mg/kg BW) or @entity5 (6 mg/kg BW) affected the refractory response. The renal vasculature was also relatively unresponsive to an intravenous infusion of AII (5 ng X kg-1 X min-1) during late gestation (day 19); in particular, the fall in ERPF in response to AII (16 +/- 3%) was markedly less than that observed in the prepregnant condition (34 +/- 3%; P less than 0.05). @entity4 (6 mg/kg BW) failed to restore this blunted response, and further attenuation was evident, despite the presence of the inhibitor (gestational day 21). We conclude that vasodilatory @entity3 do not appear to mediate the rise in renal hemodynamics, and the attenuation of the systemic and renal pressor responsiveness observed during pregnancy, insofar as these phenomena were unaffected by acute cyclooxygenase inhibition in unstressed, conscious @entity0 .

title: Evidence against the hypothesis that @entity3 are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious XXXX .

answer: @entity0


abstract: CONTEXT:    A variety of ankle self-stretching exercises have been recommended to improve ankle-dorsiflexion range of motion (DFROM) in individuals with limited ankle dorsiflexion. A @entity1 can be applied to stabilize the talus and facilitate anterior glide of the distal tibia at the talocrural joint during ankle self-stretching exercises. Novel ankle self-stretching using a @entity1 (SSS) may be a useful method of improving ankle DFROM. OBJECTIVE:    To compare the effects of 2 ankle-stretching techniques (static stretching versus SSS) on ankle DFROM. DESIGN:    Randomized controlled clinical trial. SETTING:    University research laboratory. @entity0 OR OTHER @entity0 :    Thirty-two @entity0 with limited active dorsiflexion (<20  ) while sitting (14 @entity0 and 18 @entity0 ) were recruited. MAIN OUTCOME MEASURE(S):    The @entity0 performed 2 ankle self-stretching techniques (static stretching and SSS) for 3 weeks. Active DFROM (ADFROM), passive DFROM (PDFROM), and the lunge angle were measured. An independent t test was used to compare the improvements in these values before and after the 2 stretching interventions. The level of statistical significance was set at a = .05. RESULTS:    Active DFROM and PDFROM were greater in both stretching groups after the 3-week interventions. However, ADFROM, PDFROM, and the lunge angle were greater in the SSS group than in the static-stretching group (P < .05). CONCLUSIONS:    Ankle SSS is recommended to improve ADFROM, PDFROM, and the lunge angle in individuals with limited DFROM.

title: Ankle-Dorsiflexion Range of Motion After Ankle Self-Stretching Using a XXXX .

answer: @entity1


abstract: @entity1 are a rare but diverse group of benign and @entity0 that arise within the retroperitoneal space but outside the major organs in this space. Although computed tomography and magnetic resonance imaging can demonstrate important characteristics of these @entity0 , diagnosis is often challenging for radiologists. Diagnostic challenges include precise localization of the lesion, determination of the extent of invasion, and characterization of the specific pathologic type. The first step is to determine whether the @entity0 is located within the retroperitoneal space. Displacement of normal anatomic structures of the retroperitoneum is helpful in this regard. For @entity0 that are located within the retroperitoneum, the next step is to identify the organ of origin. Specific signs, including the "beak sign," the "embedded organ sign," and the "phantom (invisible) organ sign," are useful for this purpose. When there is no definite sign that suggests the organ of origin, the diagnosis of a primary @entity0 becomes likely. Awareness of specific patterns of spread, specific @entity0 components, and @entity0 vascularity help in further narrowing the differential diagnosis. Attention to these diagnostic clues is essential in making an accurate radiologic diagnosis of @entity0 and in obtaining clinically significant information.

title: XXXX : CT and MR imaging findings with anatomic and pathologic diagnostic clues.

answer: @entity1


abstract: Discordant bone marrow (BM) involvement in @entity0 with a diagnosis of large-cell @entity8 ( @entity8 ) is characterized by marrow infiltrates predominantly composed of small lymphoid cell, cytologically compatible with low-grade @entity8 . Although this phenomenon is well described morphologically, molecular data concerning the relationship of the two lesions are lacking. The aim of the study was to investigate the clonal relationship of discordant @entity3 manifestations by using @entity13 ( @entity13 ), as well as @entity2 rearrangements, as molecular markers. @entity13 rearrangements were amplified by PCR with consensus primers directed against framework regions 3 or 2 (FR3 and FR2), followed by automated fragment length analysis and sequencing in selected cases. Rearrangements of the @entity2 gene were identified with primers against the major breakpoint region. Small BM infiltrates were isolated by laser capture microdissection. In addition, immunohistochemistry was performed on paraffin sections using antibodies against CD3, @entity10 , @entity9 , @entity2 , @entity11 , @entity4 , and the Ki67 antigen. @entity5 -embedded tissues of 21 cases diagnosed as @entity7 ( @entity7 ) with discordant BM involvement and no previous history of low-grade B-cell @entity8 were analyzed. After review of immunohistochemical stains, 5 cases were excluded either as concordant BM infiltrates by @entity3 with abundant reactive T-cells (2 cases) or as benign, reactive lymphoid infiltrates (3 cases), as confirmed by a polyclonal pattern in the @entity13 analysis. Of the remaining 16 cases, a common clonal origin was confirmed in 8 cases by the presence of an identical clonal @entity13 rearrangement or @entity2 rearrangement. In 4 cases, identification of distinct @entity13 or @entity2 rearrangements gave evidence for the presence of two clonally unrelated @entity1 . The remaining 4 cases were not evaluable for technical reasons. Morphological, phenotypical, and molecular findings were compatible with a @entity3 of germinal center origin in the majority of cases. However, in 4 cases, flow cytometric analysis of the BM infiltrates revealed a @entity6 phenotype. Two of these cases were clonally related to the @entity7 and thus represented @entity12 . In summary, discordant BM infiltrates in @entity7 represent a heterogeneous group of disorders, encompassing cases with a clonally related, clinically occult small-cell component, as well as cases with two clonally distinct, unrelated @entity7 presenting synchronously at different locations.

title: Discordant bone marrow involvement in XXXX : comparative molecular analysis reveals a heterogeneous group of disorders.

answer: @entity7


abstract: AIM: To investigate the feasibility of cold @entity4 polypectomy (CSP) in Japan. METHODS: The outcomes of 234 non-pedunculated @entity3 smaller than 10 mm in 61 @entity0 who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold @entity4 polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical @entity4 without electrocautery. RESULTS: CSPs were completed for 232 of the 234 @entity3 . Two (0.9%) @entity3 could not be removed without electrocautery. Immediate postpolypectomy @entity2 requiring endoscopic hemostasis occurred in eight lesions (3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate @entity2 after CSP for small @entity3 (6-9 mm) was significantly higher than that of diminutive @entity3 ( <= 5 mm; 15% vs 1%, respectively). Three (5%) @entity0 complained of minor @entity2 after the procedure but required no intervention. The incidence of delayed @entity2 requiring endoscopic intervention was 0.0% (95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. @entity1 involvement in the lateral margin could not be histologically assessed in 70 (40%) lesions. CONCLUSION: CSP is feasible in Japan. However, immediate @entity2 , retrieval failure and uncertain assessment of the @entity1 margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the @entity1 residue after CSP are recommended when implementing CSP in Japan.

title: Feasibility of cold XXXX polypectomy in Japan: A pilot study.

answer: @entity4


abstract: BACKGROUND: Although several risk factors associated with reduced age @entity1 ( @entity1 ) have been investigated, the results are inconsistent. Excessive stress, which leads to elevation of stress hormones, can also negatively affect reproductive ability, including by accelerating menopause. However, a direct association between stress level and @entity1 has not yet been demonstrated. Therefore, the object of this study was to investigate the association between stress level and @entity1 in Korean @entity0 . METHODS: Study @entity0 were Korean @entity0 between 40 and 70 years old who were in natural menopause during the 5th Korean National Health and Nutrition Examination Survey (n=3,176). The level of stress in daily life was estimated based on data from the mental health topics of the survey. We used the t-test and one-way analysis of variance to analyze the correlation between stress level and @entity1 . Regression (b) coefficients calculated by multiple regression analysis were used to estimate various factors affecting @entity1 . RESULTS: @entity0 who experienced a high level of stress in daily life had a lower mean @entity1 than @entity0 with a low stress level (50.17  3.7 and 50.58  3.5 years, respectively), with a statistically significant correlation (P<0.05). This correlation was still observed after adjusting for age, body mass index, menstrual regularity, and personal income (P<0.05 for variables). CONCLUSION: In Korean @entity0 between 40 and 70 years of age who are in natural menopause, there is a statistically significant correlation between stress level and @entity1 . In particular, @entity0 who experience a high level of stress in daily life have reduced @entity1 .

title: The Association between Stress Level in Daily Life and Age at Natural Menopause in Korean XXXX : Outcomes of the Korean National Health and Nutrition Examination Survey in 2010-2012.

answer: @entity0


abstract: This study concerns the significance of aberrant (nuclear/cytoplasmic) expression of @entity3 in @entity2 ( @entity2 ). On immunohistochemistry, all seven PBLs examined showed nuclear/cytoplasmic expression of @entity3 , predominantly in the squamoid corpuscles (SCs). In areas with acinar/ductular differentiation, few @entity0 cells displayed nuclear/cytoplasmic expression of @entity3 and more than half of the @entity0 cells showed membranous expression. Two out of five (40%) @entity0 examined showed missense mutations in codons 33 and 37 of exon 3 of the @entity3 gene. No mutation of the @entity1 ( @entity1 ) gene was detected in two of the remaining three @entity0 . Amplifiable DNA for @entity1 analysis was not obtained from the one other @entity0 . Immunoreactivity for @entity4 , one of the nuclear targets of @entity3 , was found predominantly in the SCs of the seven @entity0 . In contrast, the Ki-67 labelling index was 2-4% (median 3%) in the SCs and 8-18% (median 12%) in the other areas, indicating a negative correlation with nuclear @entity4 reactivity. These results imply that in PBLs, nuclear/cytoplasmic accumulation of @entity3 and overexpression of its target gene @entity4 are not associated with the induction of @entity0 cell proliferation. Nuclear/cytoplasmic accumulation of @entity3 may be related to the morphogenesis of the SCs that are considered most characteristic for @entity2 .

title: Significance of aberrant (cytoplasmic/nuclear) expression of XXXX in @entity2 .

answer: @entity3


abstract: This study concerns the significance of aberrant (nuclear/cytoplasmic) expression of @entity3 in @entity2 ( @entity2 ). On immunohistochemistry, all seven PBLs examined showed nuclear/cytoplasmic expression of @entity3 , predominantly in the squamoid corpuscles (SCs). In areas with acinar/ductular differentiation, few @entity0 cells displayed nuclear/cytoplasmic expression of @entity3 and more than half of the @entity0 cells showed membranous expression. Two out of five (40%) @entity0 examined showed missense mutations in codons 33 and 37 of exon 3 of the @entity3 gene. No mutation of the @entity1 ( @entity1 ) gene was detected in two of the remaining three @entity0 . Amplifiable DNA for @entity1 analysis was not obtained from the one other @entity0 . Immunoreactivity for @entity4 , one of the nuclear targets of @entity3 , was found predominantly in the SCs of the seven @entity0 . In contrast, the Ki-67 labelling index was 2-4% (median 3%) in the SCs and 8-18% (median 12%) in the other areas, indicating a negative correlation with nuclear @entity4 reactivity. These results imply that in PBLs, nuclear/cytoplasmic accumulation of @entity3 and overexpression of its target gene @entity4 are not associated with the induction of @entity0 cell proliferation. Nuclear/cytoplasmic accumulation of @entity3 may be related to the morphogenesis of the SCs that are considered most characteristic for @entity2 .

title: Significance of aberrant (cytoplasmic/nuclear) expression of @entity3 in XXXX .

answer: @entity2


abstract: PURPOSE: Gene expression studies provide molecular insights improving the classification of @entity0 with high-grade @entity2 . We have developed a risk estimation strategy based on a combined analysis of gene expression data to search for robust biomarkers associated with outcome in these @entity1 . EXPERIMENTAL DESIGN: We performed a meta-analysis using 3 publicly available @entity2 microarray data sets (267 @entity0 ) to define the genes related to both @entity2 and @entity0 outcome. These biomarkers were used to construct a risk-score equation based on a Cox proportional hazards model on a subset of 144 @entity0 . External validations were performed on microarray data (59 @entity0 ) and on RT-qPCR data (194 @entity0 ). The risk-score model performances (discrimination and calibration) were evaluated and compared with that of clinical risk factors, @entity5 promoter methylation status, and @entity3 mutational status. RESULTS: This interstudy cross-validation approach allowed the identification of a 4-gene signature highly correlated to survival ( @entity6 , @entity8 , @entity4 , and @entity7 ), from which an optimal survival model was built (P < 0.001 in training and validation sets). Multivariate analysis showed that the 4-gene risk score was strongly and independently associated with survival (hazard ratio = 0.46; 95% CI, 0.26-0.81; P = 0.007). Performance estimations indicated that this score added beyond standard clinical parameters and beyond both the @entity5 methylation status and the @entity3 mutational status in terms of discrimination (C statistics, 0.827 versus 0.835; P < 0.001). CONCLUSION: The 4-gene signature provides an independent risk score strongly associated with outcome of @entity0 with high-grade @entity2 .

title: A 4-gene signature associated with clinical outcome in high-grade XXXX .

answer: @entity2


abstract: A @entity0 with multiple @entity8 associated with @entity5 is reported. A 45-year-old @entity0 was admitted on February 16, 2001 under the diagnosis of @entity5 . After alpha-streptococcus was identified by a blood culture, he was treated with high doses of antibiotics. However, 2 weeks after admission, he suddenly suffered from @entity1 and mild @entity6 . A CT showed a parenchymal @entity7 in the right parietal lobe. Cerebral angiography demonstrated @entity4 of the bilateral middle cerebral artery and the left posterior cerebral artery. At first, we trapped and resected the ruptured right @entity3 . After the surgery, we tried to treat two @entity4 by endovascular treatment. During the provocation test for the posterior cerebral artery, the arterial wall was perforated by a guide wire. The parent artery was occluded by coils at this site. Although the @entity4 was still filled by retrograde blood flow, it finally disappeared six months after treatment. The left @entity3 could not be treated because the provocation test showed @entity2 . The @entity0 recovered from @entity5 after four-months of antibiotic therapy; and the unruptured @entity4 had not changed in size for 11 months. Recently, the outcome of @entity0 with @entity3 is improved by development of multimodality management. Especially, endovascular therapy may become an effective treatment for @entity4 , but it is necessary to take risks, such as arterial perforation into consideration.

title: [A case of multiple mycotic XXXX ].

answer: @entity3


abstract: PURPOSE: This study was performed to determine whether the investigational proteasome inhibitor @entity9 demonstrated selective anti-neoplastic activity against @entity7 cells expressing a mutated nucleophosmin-1 gene and to gain a better understanding of its mechanisms of action. EXPERIMENTAL DESIGN: The cytotoxic effects of @entity9 treatment were analyzed in @entity0 @entity7 cell lines and primary @entity7 samples expressing wild type or mutated @entity8 (NPMc+). The potential roles of oxidative stress in mediating cytotoxic activity were determined using flow cytometry, enzyme-based assays, and western blots. RESULTS: Apoptosis induced by @entity9 was abrogated by knock down of @entity8 /NPMc+ expression using an inducible shRNA construct and enhanced by NPMc+ overexpression. @entity1 was associated with @entity2 generation and was reduced by the addition of the antioxidant @entity3 . @entity7 cells expressing NPMc+ had significantly reduced levels of intracellular @entity6 and @entity4 associated with reduced antioxidant responses to drug treatment. Treatment of three @entity0 with relapsed @entity7 resulted in an anti- @entity5 effect in one @entity0 as demonstrated by a marked @entity5 in the peripheral blood. Efficacy was associated with @entity2 generation, reduced @entity6 levels, and reduced mRNA and protein expression of antioxidant effectors in responding cells. CONCLUSION: In this study a direct association was observed between NPMc+ expression in @entity7 , reduced antioxidant responses, and enhanced sensitivity to an oral proteasome inhibitor that induces oxidative stress. These data suggest that intracellular determinants of antioxidant responses may be good predictors of therapeutic response to @entity9 .

title: Selective toxicity of investigational @entity9 for @entity0 XXXX cells expressing mutant cytoplasmic @entity8 : Role of reactive oxygen species.

answer: @entity5


abstract: PURPOSE: This study was performed to determine whether the investigational proteasome inhibitor @entity9 demonstrated selective anti-neoplastic activity against @entity7 cells expressing a mutated nucleophosmin-1 gene and to gain a better understanding of its mechanisms of action. EXPERIMENTAL DESIGN: The cytotoxic effects of @entity9 treatment were analyzed in @entity0 @entity7 cell lines and primary @entity7 samples expressing wild type or mutated @entity8 (NPMc+). The potential roles of oxidative stress in mediating cytotoxic activity were determined using flow cytometry, enzyme-based assays, and western blots. RESULTS: Apoptosis induced by @entity9 was abrogated by knock down of @entity8 /NPMc+ expression using an inducible shRNA construct and enhanced by NPMc+ overexpression. @entity1 was associated with @entity2 generation and was reduced by the addition of the antioxidant @entity3 . @entity7 cells expressing NPMc+ had significantly reduced levels of intracellular @entity6 and @entity4 associated with reduced antioxidant responses to drug treatment. Treatment of three @entity0 with relapsed @entity7 resulted in an anti- @entity5 effect in one @entity0 as demonstrated by a marked @entity5 in the peripheral blood. Efficacy was associated with @entity2 generation, reduced @entity6 levels, and reduced mRNA and protein expression of antioxidant effectors in responding cells. CONCLUSION: In this study a direct association was observed between NPMc+ expression in @entity7 , reduced antioxidant responses, and enhanced sensitivity to an oral proteasome inhibitor that induces oxidative stress. These data suggest that intracellular determinants of antioxidant responses may be good predictors of therapeutic response to @entity9 .

title: Selective toxicity of investigational @entity9 for @entity0 @entity5 cells expressing mutant cytoplasmic XXXX : Role of reactive oxygen species.

answer: @entity8


abstract: PURPOSE: This study was performed to determine whether the investigational proteasome inhibitor @entity9 demonstrated selective anti-neoplastic activity against @entity7 cells expressing a mutated nucleophosmin-1 gene and to gain a better understanding of its mechanisms of action. EXPERIMENTAL DESIGN: The cytotoxic effects of @entity9 treatment were analyzed in @entity0 @entity7 cell lines and primary @entity7 samples expressing wild type or mutated @entity8 (NPMc+). The potential roles of oxidative stress in mediating cytotoxic activity were determined using flow cytometry, enzyme-based assays, and western blots. RESULTS: Apoptosis induced by @entity9 was abrogated by knock down of @entity8 /NPMc+ expression using an inducible shRNA construct and enhanced by NPMc+ overexpression. @entity1 was associated with @entity2 generation and was reduced by the addition of the antioxidant @entity3 . @entity7 cells expressing NPMc+ had significantly reduced levels of intracellular @entity6 and @entity4 associated with reduced antioxidant responses to drug treatment. Treatment of three @entity0 with relapsed @entity7 resulted in an anti- @entity5 effect in one @entity0 as demonstrated by a marked @entity5 in the peripheral blood. Efficacy was associated with @entity2 generation, reduced @entity6 levels, and reduced mRNA and protein expression of antioxidant effectors in responding cells. CONCLUSION: In this study a direct association was observed between NPMc+ expression in @entity7 , reduced antioxidant responses, and enhanced sensitivity to an oral proteasome inhibitor that induces oxidative stress. These data suggest that intracellular determinants of antioxidant responses may be good predictors of therapeutic response to @entity9 .

title: Selective toxicity of investigational XXXX for @entity0 @entity5 cells expressing mutant cytoplasmic @entity8 : Role of reactive oxygen species.

answer: @entity9


abstract: PURPOSE: This study was performed to determine whether the investigational proteasome inhibitor @entity9 demonstrated selective anti-neoplastic activity against @entity7 cells expressing a mutated nucleophosmin-1 gene and to gain a better understanding of its mechanisms of action. EXPERIMENTAL DESIGN: The cytotoxic effects of @entity9 treatment were analyzed in @entity0 @entity7 cell lines and primary @entity7 samples expressing wild type or mutated @entity8 (NPMc+). The potential roles of oxidative stress in mediating cytotoxic activity were determined using flow cytometry, enzyme-based assays, and western blots. RESULTS: Apoptosis induced by @entity9 was abrogated by knock down of @entity8 /NPMc+ expression using an inducible shRNA construct and enhanced by NPMc+ overexpression. @entity1 was associated with @entity2 generation and was reduced by the addition of the antioxidant @entity3 . @entity7 cells expressing NPMc+ had significantly reduced levels of intracellular @entity6 and @entity4 associated with reduced antioxidant responses to drug treatment. Treatment of three @entity0 with relapsed @entity7 resulted in an anti- @entity5 effect in one @entity0 as demonstrated by a marked @entity5 in the peripheral blood. Efficacy was associated with @entity2 generation, reduced @entity6 levels, and reduced mRNA and protein expression of antioxidant effectors in responding cells. CONCLUSION: In this study a direct association was observed between NPMc+ expression in @entity7 , reduced antioxidant responses, and enhanced sensitivity to an oral proteasome inhibitor that induces oxidative stress. These data suggest that intracellular determinants of antioxidant responses may be good predictors of therapeutic response to @entity9 .

title: Selective toxicity of investigational @entity9 for XXXX @entity5 cells expressing mutant cytoplasmic @entity8 : Role of reactive oxygen species.

answer: @entity0


abstract: The visual evoked potential (VEP) record in response to a pattern stimulus is a non invasive and reliable method of detecting central and peripheral nerve system abnormalities. VEP recording have been used in animals with @entity5 , and also in- @entity0 with @entity4 and acute severe @entity4 . Our aims were: a. to evaluate the potency of PVEP in assessing @entity4 . b. to find the rate of pathologic PVEP in @entity0 with advanced liver @entity3 . VEP was recorded in 14 chronic liver cirrhotic @entity0 (6 alcoholic, 6 @entity8 -related, 2 cryptogenic) and 14 controls. @entity0 with any @entity1 were excluded from the study. All @entity0 were subjected to the @entity6 ( @entity6 ) test, and venous blood @entity7 was measured on the same day of VEP recording. In 10/14 (71%) @entity0 some VEP recording abnormality was detected. In the cirrhotic @entity0 , @entity9 latency was significantly longer (P < 0.05) than in controls. Low amplitude was observed in 8 @entity0 compared to controls. Marked increase of N75 (3 @entity0 ) and marked increase of N145 (2 @entity0 ) were observed. Mean blood ammonia and @entity6 score were normal in all @entity0 . No correlation was found between both @entity6 score and blood ammonia levels and the @entity9 delay. Five out of 10 @entity0 with pathologic VEP developed hepatic encephalpathy during a follow-up of one year, compared to one out of 4 @entity0 with no pathology on VEP recording. VEP recording may be a valuable tool in assessing @entity0 with early @entity4 and in predicting @entity2 .

title: Early detection of XXXX by recording visual evoked potential (VEP).

answer: @entity4


abstract: BACKGROUND: @entity6 has multifactorial causes and exhibits a high frequency among very low birth @entity0 . @entity5 is hypothesized to be one cause of @entity6 ; i.e., decreased @entity0 chorionic gonadotropin (hCG) secretion caused by @entity5 is suspected to result in abnormal male external genitalia, but there is little direct evidence to support this concept. AIMS AND METHODS: The aim of this study was to elucidate the features of @entity6 and to clarify the @entity8 caused by fetal growth restriction (FGR). STUDY DESIGN AND SUBJECTS: We reviewed the clinical data of @entity0 that underwent @entity6 repair from 2005 through 2011 at Kyoto University Hospital by examining their case logs. RESULTS: Twenty @entity0 were included in this study. Fifteen (75%) of the subjects were preterm or low birth weight @entity0 . Thirteen (65%) @entity0 exhibited FGR, 60% of which displayed severe @entity6 regardless of their gestational age. In addition, 92% of the FGR @entity0 also had other @entity3 , such as @entity1 , or @entity9 . In contrast, only 14% and 43% of the non-FGR @entity0 had severe @entity6 or @entity3 other than @entity6 , respectively. Eight placental histopathological findings of FGR @entity0 were available and seven of which were suggestive of blood @entity2 such as @entity4 . CONCLUSIONS: It was confirmed that @entity0 with FGR display a high incidence of @entity6 . We found that FGR caused by @entity7 , but not low birth weight, is a risk factor for severe @entity6 associated with @entity3 . This article is protected by copyright. All rights reserved.

title: Fetal growth restriction but not preterm birth is a risk factor for severe XXXX .

answer: @entity6


abstract: UNASSIGNED: Genetic parameters, genetic trends, and genetic progress of carcass traits were estimated for 12,447 Nellore individuals from different Brazilian herds. The following carcass traits were analyzed: visual body scores of conformation ( @entity3 ), precocity (PREC), and muscularity (MUSC); rump width (RW) and rump length (RL), body size (frame); and ultrasound evaluation of ribeye area (REA), @entity0 ( @entity0 ), and @entity2 ( @entity2 ). Heritability estimates (   SE) for @entity3 , PREC, and MUSC were 0.23    0.02, 0.33    0.03, and 0.31    0.02, respectively. The heritability estimates (   SE) for RW, RL, and frame were 0.25    0.05, 0.16    0.04, and 0.31    0.03, respectively. Ultrasound of the REA, @entity0 , and @entity2 presented mean heritability estimates (   SE) of 0.38    0.03, 0.44    0.04, and 0.47    0.04, respectively. The visual body score of @entity3 had high genetic correlations with RW, RL, and frame (0.74    0.09, 0.82    0.08, and 0.83    0.04, respectively), indicating a high association of @entity3 with the measurements related to body structure. The REA had no correlation with @entity0 and @entity2 (-0.09    0.04 and -0.03    0.04, respectively) and showed only a moderate genetic correlation with MUSC (0.39    0.05). The @entity0 and @entity2 had moderate genetic correlations with PREC (0.36    0.07 and 0.29    0.07, respectively) and no correlation with frame (-0.02    0.03 and 0.05    0.05, respectively), suggesting that selection for frame had no effect on the subcutaneous fat content of the carcass. Low genetic trends and low genetic progress were obtained for REA (0.026 cm, 0.02%), @entity0 (0.0031 mm, 0.05%), and @entity2 (0.0013 mm, 0.02%), with no significant values of genetic progress detected throughout the studied period. The @entity3 , PREC, and MUSC presented high genetic trends (0.030 points, 0.030 points, and 0.029 points, respectively) and high genetic progress (0.60%, 0.56%, and 0.59%, respectively), indicating a significant genetic progress for these traits throughout the evaluated period. Carcass traits evaluated by ultrasound and visual body scores are eligible for selection and can be used in genetic improvement programs in Nellore @entity1 ; however, visual body score selection for carcass traits can result in slower genetic progress for carcass quality when compared to selection performed by ultrasound.

title: Visual body-scores selection and its influence on body size and ultrasound carcass traits in Nellore XXXX .

answer: @entity1


abstract: The renal cortical uptake kinetics of four aminoglycosides were studied in vivo. @entity1 , @entity5 , @entity2 or @entity4 were administered to @entity0 by continuous infusion over 6 hr achieving constant serum levels ranging from 0.2 to 100 micrograms/ml. Renal cortical concentrations at the end of the infusion were plotted against the steady-state serum levels. Steady-state elevations of serum @entity1 and @entity5 were associated with nonlinear increases in cortical levels, suggesting saturable uptake. Analysis of the data using Michaelis-Menten kinetics indicates that the apparent Km for @entity1 and @entity5 were 15.01 and 23.84 micrograms/ml and Vmax 149.83 and 178.36 micrograms/g of cortex per hr, respectively. The "initial" rate of uptake (at serum levels below 15 micrograms/ml) was highest for @entity1 . The cortical uptake of @entity2 was linearly related to elevations in serum levels [cortex concentration (conc) = 9.24 + 1.40 serum conc]. The initial rate of @entity2 uptake was considerably lower than that for @entity1 and @entity5 . For @entity4 , the initial rate of uptake followed Michaelis Menten kinetics and the second phase of the titration curve was linear. The equation for total @entity4 uptake was: cortex conc = 12.98 + 1.71 serum conc. Aminoglycosides exhibit differing kinetics for renal cortical uptake in the @entity0 during constant infusions. These results indicate that more than one mechanism probably mediates the uptake of each @entity3 . Depending on which mechanism predominates, the kinetic pattern may be saturable, linear or mixed.

title: In vivo uptake kinetics of aminoglycosides in the kidney cortex of XXXX .

answer: @entity0


abstract: UNASSIGNED: Malnutrition is a common problem in oncologic diseases influencing treatment outcomes, treatment complications, quality of life and survival. The potential role of @entity3 has not yet systematically been studied in neuroendocrine @entity1 (NEN), which due to growing prevalence and additional therapeutic options provide an increasing clinical challenge for diagnosis and management. The aim of this cross-sectional observational study, which included a long-term follow-up, was therefore to define the prevalence of @entity3 in 203 @entity0 with NEN using various methodological approaches and to analyze the short- and long-term outcome of malnourished @entity0 . A detailed subgroup analysis was also performed to define risk factors for poorer outcome. By applying @entity3 screening scores 21-25% of NEN- @entity0 were at risk of or demonstrated manifest @entity3 . This was confirmed by anthropometric measurements, determination of serum surrogate parameters such as albumin and bioelectrical impedance analysis particularly phase angle a. Length of hospital stay (LoS) was significantly longer in malnourished NEN- @entity0 while long-term overall survival was highly significantly reduced. @entity0 with high-grade (G3) neuroendocrine carcinomas, @entity2 and undergoing chemotherapy were at particular risk for @entity3 associated with a poorer outcome. Multivariate analysis confirmed the important and highly significant role of @entity3 as an independent prognostic factor for NEN besides proliferative capacity (G3-NEC). Malnutrition is therefore an underrecognized problem in NEN- @entity0 , which should systematically be diagnosed by widely available standard methods such Nutritional Risk Screening (NRS) score, serum albumin levels and bioelectrical impedance analysis (BIA) and treated to improve both short- and long-term outcomes.

title: Malnutrition Predicts Clinical Outcome in @entity0 with XXXX .

answer: @entity1


abstract: UNASSIGNED: Malnutrition is a common problem in oncologic diseases influencing treatment outcomes, treatment complications, quality of life and survival. The potential role of @entity3 has not yet systematically been studied in neuroendocrine @entity1 (NEN), which due to growing prevalence and additional therapeutic options provide an increasing clinical challenge for diagnosis and management. The aim of this cross-sectional observational study, which included a long-term follow-up, was therefore to define the prevalence of @entity3 in 203 @entity0 with NEN using various methodological approaches and to analyze the short- and long-term outcome of malnourished @entity0 . A detailed subgroup analysis was also performed to define risk factors for poorer outcome. By applying @entity3 screening scores 21-25% of NEN- @entity0 were at risk of or demonstrated manifest @entity3 . This was confirmed by anthropometric measurements, determination of serum surrogate parameters such as albumin and bioelectrical impedance analysis particularly phase angle a. Length of hospital stay (LoS) was significantly longer in malnourished NEN- @entity0 while long-term overall survival was highly significantly reduced. @entity0 with high-grade (G3) neuroendocrine carcinomas, @entity2 and undergoing chemotherapy were at particular risk for @entity3 associated with a poorer outcome. Multivariate analysis confirmed the important and highly significant role of @entity3 as an independent prognostic factor for NEN besides proliferative capacity (G3-NEC). Malnutrition is therefore an underrecognized problem in NEN- @entity0 , which should systematically be diagnosed by widely available standard methods such Nutritional Risk Screening (NRS) score, serum albumin levels and bioelectrical impedance analysis (BIA) and treated to improve both short- and long-term outcomes.

title: Malnutrition Predicts Clinical Outcome in XXXX with @entity1 .

answer: @entity0


abstract: BACKGROUND AND AIMS: Tissue specimen collection represents a cornerstone in diagnosis of proximal biliary tract malignancies offering great specificity, but only limited sensitivity. To improve the @entity1 detection rate, we developed a new method of forceps biopsy and compared it prospectively with endoscopic transpapillary brush cytology. @entity0 AND METHODS: 43 @entity0 with proximal biliary stenoses, which were suspect for @entity1 , undergoing endoscopic retrograde cholangiography were prospectively recruited and subjected to both biopsy [using a double-balloon enteroscopy (DBE) forceps under a guidance of a pusher and guiding catheter with guidewire] and transpapillary brush cytology. The cytological/histological findings were compared with the final clinical diagnosis. RESULTS: 35 out of 43 @entity0 had a malignant disease (33 cholangiocarcinomas, 1 @entity2 , 1 @entity3 ). The sensitivity of cytology and biopsy in these @entity0 was 49 and 69%, respectively. The method with DBE forceps allowed a pinpoint biopsy of the biliary stenoses. Both methods had 100% specificity, and, when combined, 80% of malignant processes were detected. All @entity0 with non-malignant conditions were correctly assigned by both methods. No clinically relevant complications were observed. CONCLUSIONS: The combination of forceps biopsy and transpapillary brush cytology is safe and offers superior detection rates compared to both methods alone, and therefore represents a promising approach in evaluation of proximal biliary tract processes.

title: A novel method of forceps biopsy improves the diagnosis of proximal XXXX .

answer: @entity1


abstract: BACKGROUND: For many years, fungal spores have been recognized as potential causes of @entity5 . All @entity3 cloned so far represent either secreted or cytoplasmatic proteins, but nothing is known about the involvement of fungal surface proteins in @entity2 . METHODS: A phage surface displayed cDNA-library from the mould Cladosporium herbarum was constructed and phage displaying IgE-binding proteins were selectively enriched with immobilized serum IgE from C. herbarum-sensitized individuals. Inserts encoding putative allergens were sequenced, subcloned and used to produce recombinant proteins. Allergenicity of the proteins was evaluated by IgE binding in Western blots, enzyme-linked immunosorbent assay (ELISA) and skin prick test in a total of 84 @entity0 sensitized to either C. herbarum or @entity1 and three healthy controls. RESULTS: After four rounds of affinity selection, the cDNA-library was enriched for clones displaying IgE-binding molecules. Sequencing of inserts showed that one clone contained an open reading frame predicting a protein of 105 @entity4 and a calculated molecular weight of 10.5 kDa showing the classical signature of members of the hydrophobin family. The recombinant protein, termed @entity6 , was able to bind IgE from six @entity0 sensitized to fungi in vitro. Two of those @entity0 were also included in a skin prick test survey and showed strong type I skin reactions to @entity6 , demonstrating the allergenic nature of C. herbarum hydrophobin and indicating a prevalence of sensitization in the range of 8-9%. In contrast, the hydrophobin HYP1 from @entity1 was not recognized by the sera of the same @entity0 and controls investigated with @entity6 . CONCLUSION: C. herbarum hydrophobin represents the first component of the cell wall of fungi demonstrated to act as a rare but clinically relevant allergen in vitro and in vivo.

title: Immunoglobulin E-binding and skin test reactivity to hydrophobin XXXX from Cladosporium herbarum, the first allergenic cell wall component of fungi.

answer: @entity6