abstract: UNASSIGNED: Drug sensitization with various inorganic nanoparticles (NPs) has proved to be a promising and an emergent concept in the field of nanomedicine. Rose bengal (RB), a notable photosensitizer, triggers the formation of reactive @entity0 species under green-light irradiation, and consequently, it induces @entity2 and cell death. In the present study, the effect of photoinduced dynamics of RB upon complexation with semiconductor @entity3 NPs is explored. To accomplish this, we successfully synthesized nanohybrids of RB with @entity4 NPs with a particle size of 24   nm and optically characterized them. The uniform size and integrity of the particles were confirmed by high-resolution transmission electron microscopy. UV/Vis absorption and steady-state fluorescence studies reveal the formation of the nanohybrids. ultrafast picosecond-resolved fluorescence studies of RB- @entity4 nanohybrids demonstrate an efficient electron transfer from the photoexcited drug to the semiconductor NPs. Picosecond-resolved F  rster resonance energy transfer from @entity4 NPs to RB unravel the proximity of the drug to the semiconductor at the molecular level. The photoinduced ROS formation was monitored using a @entity5 oxidation assay, which is a conventional oxidative stress indicator. It is observed that the ROS generation under green light illumination is greater at low concentrations of RB- @entity4 nanohybrids compared with free RB. Substantial photodynamic activity of the nanohybrids in bacterial and fungal cell lines validated the in vitro @entity2 results. Furthermore, the cytotoxic effect of the nanohybrids in HeLa cells, which was monitored by @entity1 assay, is also noteworthy.

title: Photoinduced Dynamics and XXXX of a Cancer Drug in Proximity of Inorganic Nanoparticles under Visible Light.

answer: @entity2


abstract: Grapes have high amounts of phenolic compounds, which can modulate the gut activity as well as modify the structure and function of the gastrointestinal tract. The microbiological activity of @entity5 , grape pomace concentrate, and @entity2 was evaluated in an in vitro study. An in vivo experiment was also conducted to study the effect of the inclusion of grape pomace concentrate and @entity2 in the diet of broiler chicks on performance, intestinal microflora (by cultured and terminal restriction fragment length polymorphism methodology), and gut morphology at 21 d of age. Dietary treatments included an antibiotic-free diet (CON), a positive control (AVP; 50 mg/kg of @entity5 ), and antibiotic-free diets containing grape pomace concentrate (GPC; 60 g/kg) or @entity2 ( @entity2 ; 7.2 g/kg). Performance was not affected by dietary treatment except in the case of birds fed the @entity2 diet, which showed decreased @entity1 . In the ileal content, birds fed CON and @entity2 diets had the highest populations of Lactobacillus. Compared with the CON diet, the AVP, GPC, and @entity2 diets increased the populations of Enterococcus and decreased the counts of Clostridium in the ileal content. In the cecal digesta, birds fed GPC and @entity2 diets had higher populations of @entity0 , Lactobacillus, Enterococcus, and Clostridium than birds in any other treatment group. Animals fed GPC and @entity2 diets showed a higher biodiversity degree than those fed control diets. The frequency of detection of several potential @entity3 -degrading bacteria as well as unidentified and uncultured organisms was increased in animals fed GPC and @entity2 diets. Birds fed the CON diet had longer villi and deeper crypt depth than birds in any other treatment group. The highest villi height:crypt depth ratio corresponded to birds fed GPC and AVP diets and the lowest to those fed CON and @entity2 diets. In conclusion, dietary @entity4 -rich grape products modify the gut morphology and intestinal microflora and increase the biodiversity degree of intestinal bacteria in broiler chicks.

title: Effects of dietary XXXX -rich grape products on intestinal microflora and gut morphology in broiler chicks.

answer: @entity4


abstract: A randomized, double-blind, parallel-group, multi-centre clinical trial was undertaken in 60 @entity0 with @entity3 or @entity5 versicolor to compare topical 2% @entity6 cream with topical 2% @entity4 cream. Treatment, by twice-daily application, was for 4 weeks or until earlier complete resolution of disease. Assessment was by laboratory mycological investigation and regular clinical/symptomatic evaluation, both during and for 2 to 6 weeks after therapy. Fifty-three @entity0 satisfactorily completed the trial, 28 of whom received @entity6 and 25 @entity4 . The groups were adequately well-matched. All assessment criteria showed @entity6 to be at least as efficacious as @entity4 , with no statistically significant differences between the two treatments. A number of assessment criteria, however, did show trends in favour of @entity6 . @entity6 resulted in mycological findings becoming negative in 92%, i.e. all but 2 of 25 @entity0 , by the end of treatment and a similar proportion (91%, 21 of 23 @entity0 ) remained mycologically negative 2 to 4 weeks after the end of therapy. With @entity4 , only 79% (19 of 24 @entity0 ) became mycologically negative during treatment and this figure decreased further to 74% (14 of 19 @entity0 ) after therapy. Essentially similar results were seen for clinical assessments of erythema, itching and desquamation, these features being significantly and progressively eliminated or improved by both treatments in high proportions of @entity0 during therapy, followed by little tendency to return after the cessation of therapy. Overall clinical assessments demonstrated statistically significant improvement during the second, third and fourth weeks of treatment with both drugs. Only 4 @entity0 (two with each treatment) were reported as showing clinical deterioration at any stage during the trial, in all cases after the end of therapy. There were no reports of local or systemic adverse reactions to either drug, and laboratory screening investigations failed to reveal any signs of @entity1 . These results indicate that a 4-week course of twice daily topical 2% @entity6 cream is extremely well tolerated and is at least as efficacious as an equivalent regimen of 2% @entity4 for the treatment of @entity3 or @entity5 versicolor. Trends in the results suggest that @entity6 may prove to be more efficacious than @entity4 , particularly in relation to elimination of laboratory evidence of persistent @entity2 , which could be reflected in a lower incidence of subsequent relapse of the disease.

title: Clinical evaluation of @entity6 cream in cutaneous @entity2 : a comparison with XXXX cream.

answer: @entity4


abstract: A randomized, double-blind, parallel-group, multi-centre clinical trial was undertaken in 60 @entity0 with @entity3 or @entity5 versicolor to compare topical 2% @entity6 cream with topical 2% @entity4 cream. Treatment, by twice-daily application, was for 4 weeks or until earlier complete resolution of disease. Assessment was by laboratory mycological investigation and regular clinical/symptomatic evaluation, both during and for 2 to 6 weeks after therapy. Fifty-three @entity0 satisfactorily completed the trial, 28 of whom received @entity6 and 25 @entity4 . The groups were adequately well-matched. All assessment criteria showed @entity6 to be at least as efficacious as @entity4 , with no statistically significant differences between the two treatments. A number of assessment criteria, however, did show trends in favour of @entity6 . @entity6 resulted in mycological findings becoming negative in 92%, i.e. all but 2 of 25 @entity0 , by the end of treatment and a similar proportion (91%, 21 of 23 @entity0 ) remained mycologically negative 2 to 4 weeks after the end of therapy. With @entity4 , only 79% (19 of 24 @entity0 ) became mycologically negative during treatment and this figure decreased further to 74% (14 of 19 @entity0 ) after therapy. Essentially similar results were seen for clinical assessments of erythema, itching and desquamation, these features being significantly and progressively eliminated or improved by both treatments in high proportions of @entity0 during therapy, followed by little tendency to return after the cessation of therapy. Overall clinical assessments demonstrated statistically significant improvement during the second, third and fourth weeks of treatment with both drugs. Only 4 @entity0 (two with each treatment) were reported as showing clinical deterioration at any stage during the trial, in all cases after the end of therapy. There were no reports of local or systemic adverse reactions to either drug, and laboratory screening investigations failed to reveal any signs of @entity1 . These results indicate that a 4-week course of twice daily topical 2% @entity6 cream is extremely well tolerated and is at least as efficacious as an equivalent regimen of 2% @entity4 for the treatment of @entity3 or @entity5 versicolor. Trends in the results suggest that @entity6 may prove to be more efficacious than @entity4 , particularly in relation to elimination of laboratory evidence of persistent @entity2 , which could be reflected in a lower incidence of subsequent relapse of the disease.

title: Clinical evaluation of XXXX cream in cutaneous @entity2 : a comparison with @entity4 cream.

answer: @entity6


abstract: A randomized, double-blind, parallel-group, multi-centre clinical trial was undertaken in 60 @entity0 with @entity3 or @entity5 versicolor to compare topical 2% @entity6 cream with topical 2% @entity4 cream. Treatment, by twice-daily application, was for 4 weeks or until earlier complete resolution of disease. Assessment was by laboratory mycological investigation and regular clinical/symptomatic evaluation, both during and for 2 to 6 weeks after therapy. Fifty-three @entity0 satisfactorily completed the trial, 28 of whom received @entity6 and 25 @entity4 . The groups were adequately well-matched. All assessment criteria showed @entity6 to be at least as efficacious as @entity4 , with no statistically significant differences between the two treatments. A number of assessment criteria, however, did show trends in favour of @entity6 . @entity6 resulted in mycological findings becoming negative in 92%, i.e. all but 2 of 25 @entity0 , by the end of treatment and a similar proportion (91%, 21 of 23 @entity0 ) remained mycologically negative 2 to 4 weeks after the end of therapy. With @entity4 , only 79% (19 of 24 @entity0 ) became mycologically negative during treatment and this figure decreased further to 74% (14 of 19 @entity0 ) after therapy. Essentially similar results were seen for clinical assessments of erythema, itching and desquamation, these features being significantly and progressively eliminated or improved by both treatments in high proportions of @entity0 during therapy, followed by little tendency to return after the cessation of therapy. Overall clinical assessments demonstrated statistically significant improvement during the second, third and fourth weeks of treatment with both drugs. Only 4 @entity0 (two with each treatment) were reported as showing clinical deterioration at any stage during the trial, in all cases after the end of therapy. There were no reports of local or systemic adverse reactions to either drug, and laboratory screening investigations failed to reveal any signs of @entity1 . These results indicate that a 4-week course of twice daily topical 2% @entity6 cream is extremely well tolerated and is at least as efficacious as an equivalent regimen of 2% @entity4 for the treatment of @entity3 or @entity5 versicolor. Trends in the results suggest that @entity6 may prove to be more efficacious than @entity4 , particularly in relation to elimination of laboratory evidence of persistent @entity2 , which could be reflected in a lower incidence of subsequent relapse of the disease.

title: Clinical evaluation of @entity6 cream in cutaneous XXXX : a comparison with @entity4 cream.

answer: @entity2


abstract: UNASSIGNED: Neoplastic cells accumulate @entity3 , an event which provides selective advantages and is frequently associated with @entity6 overexpression. Little is known about @entity3 homeostasis in @entity0 cells. Therefore, we used the @entity2 LoVo cell model and compared @entity1 -resistant to sensitive cells. In resistant cells the concentration of total @entity3 is higher while its influx capacity is lower than in sensitive cells. Accordingly, resistant cells express lower amounts of the @entity4 and 7, both involved in @entity3 transport. While decreased @entity4 levels are due to transcriptional regulation, post-transcriptional events are involved in reducing the amounts of @entity6 . Indeed, the calpain inhibitor @entity5 markedly increases the levels of @entity6 in resistant cells. In @entity1 -sensitive cells, silencing @entity6 shifts the phenotype to one more similar to resistant cells, since in these cells silencing @entity6 significantly decreases the influx of @entity3 , increases its intracellular concentration and increases resistance to @entity1 . On the other hand, calpain inhibition upregulates @entity6 , decreases intracellular @entity3 and enhances the sensitivity to @entity1 of resistant LoVo cells. We conclude that in LoVo cells drug resistance is associated with alteration of @entity3 homeostasis through modulation of @entity6 . Our data suggest that @entity6 expression may be an additional undisclosed player in chemoresistance.

title: @entity3 homeostasis in XXXX LoVo cells sensitive or resistant to @entity1 .

answer: @entity2


abstract: UNASSIGNED: Neoplastic cells accumulate @entity3 , an event which provides selective advantages and is frequently associated with @entity6 overexpression. Little is known about @entity3 homeostasis in @entity0 cells. Therefore, we used the @entity2 LoVo cell model and compared @entity1 -resistant to sensitive cells. In resistant cells the concentration of total @entity3 is higher while its influx capacity is lower than in sensitive cells. Accordingly, resistant cells express lower amounts of the @entity4 and 7, both involved in @entity3 transport. While decreased @entity4 levels are due to transcriptional regulation, post-transcriptional events are involved in reducing the amounts of @entity6 . Indeed, the calpain inhibitor @entity5 markedly increases the levels of @entity6 in resistant cells. In @entity1 -sensitive cells, silencing @entity6 shifts the phenotype to one more similar to resistant cells, since in these cells silencing @entity6 significantly decreases the influx of @entity3 , increases its intracellular concentration and increases resistance to @entity1 . On the other hand, calpain inhibition upregulates @entity6 , decreases intracellular @entity3 and enhances the sensitivity to @entity1 of resistant LoVo cells. We conclude that in LoVo cells drug resistance is associated with alteration of @entity3 homeostasis through modulation of @entity6 . Our data suggest that @entity6 expression may be an additional undisclosed player in chemoresistance.

title: @entity3 homeostasis in @entity2 LoVo cells sensitive or resistant to XXXX .

answer: @entity1


abstract: UNASSIGNED: Neoplastic cells accumulate @entity3 , an event which provides selective advantages and is frequently associated with @entity6 overexpression. Little is known about @entity3 homeostasis in @entity0 cells. Therefore, we used the @entity2 LoVo cell model and compared @entity1 -resistant to sensitive cells. In resistant cells the concentration of total @entity3 is higher while its influx capacity is lower than in sensitive cells. Accordingly, resistant cells express lower amounts of the @entity4 and 7, both involved in @entity3 transport. While decreased @entity4 levels are due to transcriptional regulation, post-transcriptional events are involved in reducing the amounts of @entity6 . Indeed, the calpain inhibitor @entity5 markedly increases the levels of @entity6 in resistant cells. In @entity1 -sensitive cells, silencing @entity6 shifts the phenotype to one more similar to resistant cells, since in these cells silencing @entity6 significantly decreases the influx of @entity3 , increases its intracellular concentration and increases resistance to @entity1 . On the other hand, calpain inhibition upregulates @entity6 , decreases intracellular @entity3 and enhances the sensitivity to @entity1 of resistant LoVo cells. We conclude that in LoVo cells drug resistance is associated with alteration of @entity3 homeostasis through modulation of @entity6 . Our data suggest that @entity6 expression may be an additional undisclosed player in chemoresistance.

title: XXXX homeostasis in @entity2 LoVo cells sensitive or resistant to @entity1 .

answer: @entity3


abstract: INTRODUCTION: Although @entity5 cuff repair is minimally invasive, there is still considerable @entity4 , especially during the first 48hours. The present study assessed the short-term efficacy and safety of @entity9 ( @entity9 ) injection associated to corticosteroids in @entity5 cuff tear surgery. MATERIAL AND METHOD: A single-center prospective randomized study included 50 @entity0 undergoing @entity5 cuff tear surgery. The study group received subacromial injection of a mixture of @entity6 , @entity7 and @entity8 associated to intra-articular injection of @entity6 plus @entity8 ; the control group received only isotonic saline. All @entity0 had had 24hours self-administered @entity6 associated to standard analgesia. Postoperative data were recorded at 30minutes and 1, 2, 4, 6, 12, 18 and 24hours: @entity1 intensity, @entity6 intake and side effects, and also time to first @entity6 bolus and additional analgesic intake. Constant, ASES and SST functional scores were recorded at 3 months. RESULTS: @entity4 was significantly less intense in the @entity9 group than in controls at 30min, H1, H4, H6, @entity10 , @entity11 and H24 (P<0.05). A rebound at D10 occurred in both groups. During the first 24hours, @entity9 significantly reduced cumulative resort to @entity6 (P<0.05 at H1/2, P<0.001 at H1-24). Mean time to first bolus was significantly longer in the @entity9 group (71.6 vs. 33min; P<0.05). The rate of opioid-related side effects was similar between groups. At last follow-up, functional scores were similar between groups. There were no cases of @entity3 or delayed @entity2 . CONCLUSION: @entity9 associated to corticosteroids after @entity5 cuff tear surgery provided immediate benefit in terms of analgesia and @entity6 sparing, without apparent risk of @entity3 . The practice is presently little known in France and deserves longer-term assessment, especially as regards functional rehabilitation and tendon healing. LEVEL OF EVIDENCE: 2.

title: Efficacy of multimodal analgesia injection combined with corticosteroids after XXXX cuff repair.

answer: @entity5


abstract: UNASSIGNED: The aim of this systematic review was to investigate whether the use of antimicrobial photodynamic therapy (aPDT) as an adjuvant to scaling and root planning (SRP) yields better results than SRP alone or associated with systemic antibiotics in the treatment of @entity1 ( @entity1 ). A meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statements and Cochrane Collaboration recommendations. The search for relevant studies (earliest record to January 2015) was carried out in seven databases, followed by a manual search. Methodological quality assessment of the studies selected was based on an analysis of the risk of bias. At each time point of follow-up, the existence of significant differences (p   <   0.05) in clinical attachment level (CAL) gain and @entity0 ( @entity0 ) reduction (primary outcomes) between groups was assessed with RevMan software 5.0. Heterogeneity between studies was assessed by the Higgin test (I (2)). Four randomized controlled trials (RCTs) satisfied the eligibility criteria of this review. Only one study was found to have a low risk of bias. There were no significant differences in @entity0 reduction (mean difference 0.33, 95  % confidence interval -0.32 to 0.98, p   =   0.32) and @entity2 (mean difference 0.20, 95  % confidence interval -0.41 to 0.81, p   =   0.53) between the test and control interventions. At present, therefore, when compared to SRP alone or associated with systemic antibiotics, the evidence suggests that the association of aPDT   +   SRP is of no additional benefit in the nonsurgical treatment of @entity1 .

title: Antimicrobial photodynamic therapy in the treatment of XXXX : a systematic review and meta-analysis.

answer: @entity1


abstract: We performed a population-based case-control study of risk factors for primary invasive @entity1 type b (Hib) disease in metropolitan Atlanta from July 1, 1983, through June 30, 1984. Active surveillance identified 102 cases in @entity0 less than 5 years of age, 89 of whom lived in households with telephones. We used random digit dialing to select 530 controls who were postmatched to cases by age. Multivariate analysis showed a significant association between @entity2 and two independent exposure factors, household crowding (odds ratio (OR) 2.7, 95% confidence limits (CL) 1.3 to 5.6) and day-care attendance. For day-care attendance, relative risk was highest in 2- to 5-month-old @entity0 (OR 17.7, 95% CL 5.8 to 54.4) and declined to 9.4 (4.3 to 20.9) at ages 6 to 11 months, 5.0 (2.7 to 9.3) at 12 to 23 months, 2.7 (1.3 to 5.5) at 24 to 35 months, and 1.4 (0.5 to 4.0) in 36- to 59-month-old @entity0 . Fifty percent of all invasive @entity2 that occurred during the study period was attributable to exposure to day-care; the attributable risk for household crowding was 18%. Dose-response effects were observed for hours per week of day-care attendance and extent of household crowding. Breast-feeding was protective for @entity0 less than 6 months of age (OR 0.08, 95% CL 0.01 to 0.59). After controlling for socioeconomic and other confounding factors, we could demonstrate no effect of black race on cumulative risk of invasive @entity2 . Our study defines high-risk groups and provides a population-based model of the interrelationship between risk factors associated with invasive @entity2 .

title: Primary invasive XXXX type b disease: a population-based assessment of risk factors.

answer: @entity1


abstract: ABSTRACT: A workshop was held at the National Institute for @entity1 and Digestive and @entity2 with a focus on the impact of sleep and circadian disruption on energy balance and @entity1 . The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/ @entity1 . There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in @entity0 to move beyond measurements of @entity9 and @entity7 and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for @entity4 @entity8 to be incorporated into all ongoing cohort studies related to @entity1 risk. Studies in @entity0 need to complement the elegant short-term laboratory-based @entity0 studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of @entity0 with @entity5 (OSA) prevents or delays the onset of @entity1 and whether temporal restricted feeding has the same impact on @entity6 rates in @entity0 as it does in @entity3 .

title: Impact of Sleep and Circadian Disruption on Energy Balance and XXXX : A Summary of Workshop Discussions.

answer: @entity1


abstract: OBJECTIVE: To identify clinical spectrum, management and outcome of @entity4 . METHODS: The retrospective study was conducted at the Shifa International Hospital, Islamabad, Pakistan, and comprised microbiological records of all the babies admitted to the Neonatal Intensive Care Unit from January 2009 to January 2014 that were reviewed to identify those with positive candida cultures. Medical records were analysed for demographic and clinical spectrum features, management and outcome. SPSS 16 was used statistical analysis. RESULTS: Of the total 1550 neonatal admissions, 560 (36%) had positive cultures, and, of them, candida was isolated in 49(8.8%) neonates. Among them, 13(26%) had @entity3 and the rest had candida species. Majority were males 34(70%), and preterm with 30(61%) being <37 weeks. The mean birth weight was 2000  873 grams. Mean age at admission was 6  7.6 days. Overall, 39(80%) had >= 2 risk factors. The commonest site of isolation was blood in 41(84%). Besides, 32 (65%) received @entity2 alone for treatment. Mean duration of anti-fungal therapy was 10  5 days (range: 1-21 days). Twelve (24%) neonates expired and the cause of @entity0 was @entity1 in 10(20%) cases. Mortality was not significantly associated with gender, place of birth, gestation, risk factors, length of stay, prior antibiotic exposure or receipt of antifungal prophylaxis except those who were  <=1500 grams (p<0.05). CONCLUSIONS: Approximately one in ten at-risk neonates may develop @entity1 with high mortality. Early institution of anti-fungal therapy may prove to be life-saving.

title: Clinical spectrum, management and outcome of XXXX .

answer: @entity4


abstract: OBJECTIVE: We previously reported that various types of @entity4 ( @entity4 ) patterns contain intracytoplasmic eosinophilic inclusions or Mallory bodies (inclusions) that are ubiquitin positive (Ub+). In the present study, we examined tissues with the @entity7 pattern (OP) to determine if they contain inclusions and Ub+ pneumocytes using lobectomized specimens. METHODS: Tissues from 34 @entity0 with secondary OP, which appeared in 33 @entity3 and 1 @entity5 , were histologically evaluated for the type of intraluminal granulation tissue and the presence of @entity6 and inclusions. Granulation tissues were classified into polypoid, mural and occluded subtypes according to Basset's criteria and scored. RESULTS: Inclusions were noted in 5.9% of the secondary OP cases with light microscope. Ub+ pneumocytes were detected after immunostaining and all inclusions were Ub+. Ub+ pneumocytes (inclusions) were noted in 14.7% of the secondary OP cases. OP contained pneumocyte @entity6 and @entity1 without a significant difference in the Ub+ and Ub- subgroups. Although there was no significant difference in the polypoid type of granulation tissue between the Ub+ and Ub- negative (Ub-) subgroups, the Ub+ subgroup had significant increases (p<0.05) in the mural-occluded type of granulation tissue (Ub+: 1.76  0.64, n=5 vs. Ub-: 0.72  0.87, n=29) as compared to the Ub- subgroup. CONCLUSION: Some @entity0 with secondary OP had Ub+ inclusions as @entity2 .

title: Ubiquitin-positive pneumocytes and inclusion bodies are present in XXXX .

answer: @entity7


abstract: Hemisection of the @entity0 spinal cord at thoracic level 13 provides a model of @entity3 that is characterized by @entity2 attributable to hyperexcitability of dorsal horn neurons. Presuming that this hyperexcitability can be explained in part by interruption of descending inhibitory modulation by @entity1 , we hypothesized that intrathecal transplantation of RN46A-B14 serotonergic precursor cells, which secrete @entity1 and @entity5 , would reduce this hyperexcitability by normalizing the responses of low-threshold mechanoreceptive, nociceptive-specific, and multireceptive dorsal horn neurons. Three groups (n=45 total) of 30-day-old male @entity0 underwent thoracic level 13 spinal hemisection, after which four weeks were allowed for development of @entity4 and @entity4 . The three groups of animals received transplants of no cells, 10(6) RN46A-V1 (vector-only) or 10(6) RN46A-B14 cells at lumbar segments 2-3. Electrophysiological experiments were done two weeks later. Low-threshold mechanoreceptive, nociceptive-specific, and multireceptive cells (n=394 total) were isolated at depths of 1-300 and 301-1000 micro in the lumbar enlargement. Responses to innocuous and noxious peripheral stimuli were characterized, and analyses of population responses were performed. Compared with normal animals, dorsal horn neurons of all types in hemisected animals showed increased responsiveness to peripheral stimuli. This was true for neurons on both sides of the spinal cord. After hemisection, the proportion of neurons classified as multireceptive cells increased, and interspike intervals of spontaneous discharges became less uniform after hemisection. Transplantation of RN46A-B14 cells restored evoked responses to near-control levels, normalized background activity, and returned the proportion of multireceptive cells to the control level. Restoration of normal activity was reversed with @entity6 .These electrophysiological results corroborate anatomical and behavioral studies showing the effectiveness of serotonergic neural precursors in correcting phenomena associated with @entity2 following @entity3 , and provide mechanistic insights regarding mode of action.

title: Serotonergic neural precursor cell grafts attenuate bilateral hyperexcitability of dorsal horn neurons after spinal hemisection in XXXX .

answer: @entity0


abstract: We reviewed 530 @entity0 treated with anatrophic nephrolithotomy during a 14.5-year period. Significant postoperative @entity1 occurred in 34 cases (6.4 per cent). The average postoperative blood transfusion requirement in this group was 5,279 cc. @entity3 @entity0 were significantly older and they had worse renal function compared to the nonbleeding group. If @entity3 did not begin immediately it usually started 5 to 8 days postoperatively. @entity3 were identified in 6 @entity0 and correction allowed nonoperative management in 4. Epsilon @entity5 was helpful only in the treatment of @entity0 with slow, lower @entity3 . Eight @entity0 required 9 open renal explorations to control @entity3 . Two @entity4 and 1 false @entity2 were identified. An attempt at angiographic embolization of an @entity4 was unsuccessful. Only 1 @entity0 required a nephrectomy (1 of 34 or 2.9 per cent) and there was no mortality. A treatment plan for this complication is described.

title: Postoperative anatrophic XXXX .

answer: @entity3


abstract: PURPOSE: @entity3 is a @entity1 affecting the proximal enthesis of the extensor carpi radialis brevis tendon. Although magnetic resonance imaging (MRI) has been highlighted as an important diagnostic tool, to our knowledge no previous study has established the observer reliability of MRI for @entity3 or the relationship between MRI abnormalities of the common extensor origin and the @entity0 's clinical assessment. METHODS: Twenty-one consecutive subjects with a clinical diagnosis of chronic @entity3 were assessed. An MRI scoring system was used to grade the degree of @entity2 and @entity2 of the common extensor origin from the lateral epicondyle. Three independent musculoskeletal radiologists, who were blinded to @entity0 clinical severity, scored images separately. Each scored the images on 3 separate occasions. Clinical symptoms were assessed using the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) and Upper Extremity Functional Scale clinical measures. Maximum pain levels were scored on a visual analog scale, and objective assessment was made with grip strength. RESULTS: Moderate or severe signal changes consistent with @entity2 were observed in 18 of 21 @entity0 . Significant inter-observer reliability and intra-observer agreement were demonstrated for MRI interpretation of grade of @entity2 and @entity2 . Significant negative correlation was found between the @entity2 and both the QuickDASH and maximum pain levels. CONCLUSIONS: Magnetic resonance imaging is a reliable tool in determining radiological severity of @entity3 . However, the severity of MRI signal changes does not positively correlate with symptoms. These findings question the validity of MRI in the assessment of @entity3 .

title: The reliability and validity of magnetic resonance imaging in the assessment of chronic XXXX .

answer: @entity3


abstract: BACKGROUND _ AIMS: The @entity4 ( @entity4 ) was originally developed based on data from @entity0 who underwent the transjugular intrahepatic portosystemic shunt procedure. An updated @entity4 based on data from @entity0 awaiting liver transplantation should improve mortality prediction and allocation efficiency. METHODS: Wait-list data from adult primary liver transplantation candidates from the Organ Procurement and Transplantation Network were divided into a model derivation set (2005-2006; n=14,214) and validation set (2007-2008; n=13,945). Cox regression analysis was used to derive and validate an optimized model that updated coefficients and upper and lower bounds for @entity4 components and included serum levels of @entity3 . Main outcomes measure was ability to predict 90-day mortality of @entity0 on the liver transplantation wait list. RESULTS: Optimized @entity4 score updated coefficients and implemented new upper and lower bounds for @entity2 (0.8 and 3.0 mg/dL, respectively) and international normalized ratio (1 and 3, respectively). Serum @entity3 concentrations significantly predicted mortality, even after adjusting for the updated @entity4 model. The final model, based on updated fit of the 4 variables (ie, @entity1 , @entity2 , international normalized ratio, and @entity3 ) had a modest yet statistically significant gain in discrimination (concordance: 0.878 vs 0.865; P<.01) in the validation dataset. Utilization of the new score could affect up to 12% of @entity0 (based on changed score for 459 of 3981 transplants in the validation set). CONCLUSIONS: Modification of @entity4 score to update coefficients, change upper and lower bounds, and incorporate serum @entity3 levels improved wait-list mortality prediction and should increase efficiency of allocation of donated livers.

title: A revised model for end-stage liver disease optimizes prediction of mortality among XXXX awaiting liver transplantation.

answer: @entity0


abstract: BACKGROUND: @entity2 of the @entity3 ( @entity3 ) is a common condition causing significant disability. The aim of this study is to ascertain whether an intra-articular corticosteroid injection leads to @entity0 relief and increased function and what is the duration and magnitude of this effect. METHODS: A systematic review with a critical appraisal of identified studies that met the inclusion criteria was performed. Two authors performed the literature review by independently searching the Cochrane, PubMed and Google Scholar databases. RESULTS: A total of 118 relevant articles were found, but only nine studies met the inclusion criteria which included 4 double-blinded randomised control trials (RCTs) and 5 prospective case series. There is some evidence in the literature to support the efficacy of @entity1 injections into the @entity3 . Most studies do suggest a good short-term benefit. However, one identifies no benefit over placebo but two studies found a benefit lasting at least 6  months. CONCLUSIONS: This study demonstrates that there are potentially significant although short-term benefits to be gained from @entity1 injections into the @entity3 . They can lead to @entity0 relief and improved function, certainly in the first 1 to 3  months post-injection. @entity1 injections are a low-risk procedure and are helpful in delaying or avoiding the need for surgery.

title: Intra-articular corticosteroid injections to manage trapeziometacarpal XXXX -a systematic review.

answer: @entity2


abstract: BACKGROUND: Glycosidases profusion in male reproductive fluids suggests a possible relationship with sperm function. Although Hexosaminidase (Hex) is the most active glycosidase in epididymal fluid and seminal plasma, as well as in spermatozoa, Glucosidase is considered a marker for epididymal function and @entity1 . OBJECTIVE: The aim of this study was to determine Hex activity in seminal plasma from @entity0 with normal and abnormal spermograms and analyze its correlation with seminal parameters. MATERIALS AND METHODS: In this cross sectional study, seminal plasma from azoospermic, asthenozoospermic, teratozoospermic, and normozoospermic @entity0 was analyzed for the activity of: total Hex, @entity2 isoform, and glucosidase. Besides, @entity3 levels were determined, and the amount of Hex was quantified by immunoblot with a specific antibody. Correlation of Hex activity with seminal parameters was also analyzed. RESULTS: Hex activity, like glucosidase, was significantly reduced in azoospermic samples (44, 49, and 60% reduction for total Hex, @entity2 and glucosidase, respectively). A reduced amount of Hex in azoospermic samples was confirmed by western immunoblot. Hex activity was negatively correlated with round cells in azoospermic samples and positively correlated with motility in asthenozoospermic ones. CONCLUSION: The results suggested that Hex activity was reduced in azoospermic samples and this was due to a lower amount of enzyme. The correlation to seminal parameters related to particular pathologies suggests a possible relationship of Hex with fertilizing capacity.

title: Seminal plasma hexosaminidase in XXXX with normal and abnormal spermograms.

answer: @entity0


abstract: INTRODUCTION: @entity6 , a rare benign disease with indolent course, is best described as an association between soft tissue @entity7 and @entity3 of the bones. In this report, we describe the first case of this syndrome from Saudi Arabia. CASE PRESENTATION: A 24-year-old male in  overall good health status, presented with progressive left knee swelling over 6 years with no other associated symptoms. The swelling measured 5  cm in diameter, with smooth surface, and soft palpable texture. Radiological examination followed by histopathological examination of the excised mass confirmed our diagnosis of @entity6 . The @entity0 was closely followed up with systematic examination with no recurrence. DISCUSSION: @entity3 , soft tissue @entity7 and @entity2 like @entity8 characterize @entity6 . Furthermore, @entity3 is found to be associated with GNA1S gene mutation. Many @entity0 can have asymptomatic course of the disease but may present with pathological @entity5 , @entity4 , and limitation of movement when the @entity7 is near the joints or just simple cosmetically disturbing swelling like in our case. CONCLUSION: @entity0 with such presentation need to be investigated thoroughly to rule out associated diseases and to evaluate the extent of such pathology. The improvement of radiological modalities can help in narrowing the differential diagnosis and following the @entity0 to early detect the recurrence or any @entity1 .

title: XXXX : Report of its first incidence in the Middle East and a literature review.

answer: @entity6


abstract: BACKGROUND: @entity0 with @entity1 ( @entity1 ) expect and perceive social rejection stronger than healthy individuals. Shifting ones attention from oneself to others has been suggested as a mechanism to deal with the experience of social rejection. Here, we investigated whether @entity1 @entity0 avoid increased self-awareness and whether this is done intentionally. METHODS: Thirty @entity1 @entity0 and 30 healthy control @entity0 , all na  ve of the study's purpose, were asked to choose either a seat facing a mirror (self-awareness) or not facing the mirror (avoidance of self-awareness). Afterwards they were asked to indicate if they have chosen the seat intentionally. RESULTS: @entity1 @entity0 avoided as a trend the chair facing the mirror more often than healthy control @entity0 . 90  % of the @entity0 reported that they made their seating decision intentionally in contrast to 26.7  % of the healthy @entity0 (odd ratio   =   24.75). CONCLUSIONS: Results revealed altered reactions to self-awareness cues in @entity1 . While @entity1 @entity0 avoided such a cue slightly more often, they were more often aware of their behavior than healthy @entity0 . As possible explanations, a negative body related, shame-prone self-concept as well as a simultaneously increased degree of self-focused attention are suggested.

title: Can't stand the look in the mirror? Self-awareness avoidance in XXXX .

answer: @entity1


abstract: OBJECTIVE: Medically unexplained symptoms (MUSs) are a humanitarian and economic burden. Among them, @entity1 complaints without organic pathology are the most prevalent. Theoretically, activated illness-related memory may cause reporting of symptoms by changing perception and interpretation of bodily signals to the extent that they are not tolerated and become complaints. We tested whether activating illness-related memory without conscious awareness leads to @entity1 (PT). METHODS: Activation of illness-related memory without conscious awareness was manipulated by a subliminal priming technique. Eighty @entity0 were randomly assigned to four conditions, with prime words describing either (a) health complaints (HCs), to activate an illness-related memory, or three control categories: (b) neutral content, (c) general bodily sensations, and (d) negative valence. The latter two conditions were added to test the alternative hypotheses that reduced PT could be observed with the semantic activation of these two components of HCs. We measured PT using a cold pressor task. RESULTS: @entity0 who were subliminally primed with HC words reported lower PT compared with @entity0 who were primed with neutral words. Priming with the other words did not lead to significantly different effects relative to priming with neutral words. CONCLUSIONS: The findings suggest that PT can be involuntarily decreased by activating illness-related memory. This implies partial evidence for a crucial element of a cognitive model of medically unexplained symptoms, which holds that chronically activated illness-related memory causes the development of somatic complaints without observable bodily pathology.

title: Decreasing XXXX tolerance outside of awareness.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: @entity1 are responsible for a large proportion of @entity3 in the world. Among survivors, the majority of limiting sequelae observed is motor in origin; but when sensorial pathways or centers are affected @entity0 can evolve with sensorial changes in the body region represented by the area of the brain affected. When the affected area is related to the thalamus the @entity0 might develop @entity8 . The objective of this report was to demonstrate the use of electroacupuncture as adjuvant in the treatment of central @entity2 , diagnosed as @entity8 difficult to control with pharmacologic therapy. CASE REPORT: This is a 46 year-old female with history of @entity4 in the left temporoparietal region in April 2003 that evolved to right @entity5 and hemitaxia. One year later, the @entity0 developed continuous, insidious @entity2 on the right side of the body with @entity6 and hyperalgia, diagnosed as @entity8 . In January 2006, she was admitted to the department of @entity2 therapy and palliative care of Santa @entity9 de Miseric  rdia de S  o Paulo where pharmacologic treatment was instituted with poor response; she was scheduled for neurofunctional surgery. In July 2009, electroacupuncture, in an attempt to obtain @entity2 control, was proposed to the @entity0 . Electroacupuncture was done on points in the scalp. After the 11(th) session, her @entity2 was controlled, with no use of opioids or topical @entity7 , her well-being had increased, her motor coordination improved, she presented @entity2 reduction, complete in hand and face. CONCLUSIONS: The efficacy of electroacupuncture in @entity2 control and well-being are in agreement with modern studies which demonstrated activation of antinociceptive pathways in the brain. Controlled prospective studies are required to reaffirm and consolidate electroacupuncture as an important technique in controlling central @entity2 .

title: Acupuncture as adjuvant therapy in XXXX : case report.

answer: @entity8


abstract: INTRODUCTION: Endoscopic sinus surgery is a common procedure performed by otolaryngologists. This study evaluated the efficacy of intravenous (IV) @entity6 (TA) on @entity5 in @entity0 undergoing elective @entity1 ( @entity1 ). MATERIALS AND METHODS: The present study was performed in 170 @entity0 scheduled for @entity1 surgery under general anesthesia in order to examine the effects of IV TA on providing a bloodless surgical field and to evaluate the amount of @entity5 . One hundred @entity0 received intravenous TA and 70 @entity0 received placebo. @entity5 was estimated by the attending anesthesiologist at the end of surgery by accounting for @entity2 and irrigation fluid in a 25 mL-graded suction canister and nasopharyngeal packing (measured weight of packing on the electronic scale). Hemodynamic variables were monitored and coagulation profile was determined. RESULTS: A total of 170 @entity0 (90 male [53%] and 80 female [47%]), mean age 30.54  4.14 years, were evaluated. There was a significantly lower @entity5 volume in the TA group than in the placebo group (107.7  45.1 vs. 189.3  51 mL; P<0.001). There was no significant difference between pre- and postoperative hematocrit (38.81   4.20 vs. 36.60   3.35) or pre- and postoperative hemoglobin (12.51   2.5 vs. 11.64  1.9) levels in the TA group (P>0.05). Moreover, the difference between the TA and control groups regarding postoperative hematocrit (34.65  4.45 vs. 36.60  3.35) and hemoglobin (10.81  2.1vs. 11.64  1.9) levels was not significant (P>0.05). Vomiting and @entity3 in the control group was greater than in the control group, but the difference was not significant (P>0.05). We did not detect significant coagulation alterations in the TA group. CONCLUSION: TA significantly decreased @entity5 without increasing side effects such as alteration in coagulation parameters, hemodynamic changes, and @entity4 and @entity3 . Use of TA can avoid the need for antihypertensive agents to reduce @entity2 in @entity1 .

title: Impact of Intravenous @entity6 on XXXX During Endoscopic Sinus Surgery.

answer: @entity5


abstract: INTRODUCTION: Endoscopic sinus surgery is a common procedure performed by otolaryngologists. This study evaluated the efficacy of intravenous (IV) @entity6 (TA) on @entity5 in @entity0 undergoing elective @entity1 ( @entity1 ). MATERIALS AND METHODS: The present study was performed in 170 @entity0 scheduled for @entity1 surgery under general anesthesia in order to examine the effects of IV TA on providing a bloodless surgical field and to evaluate the amount of @entity5 . One hundred @entity0 received intravenous TA and 70 @entity0 received placebo. @entity5 was estimated by the attending anesthesiologist at the end of surgery by accounting for @entity2 and irrigation fluid in a 25 mL-graded suction canister and nasopharyngeal packing (measured weight of packing on the electronic scale). Hemodynamic variables were monitored and coagulation profile was determined. RESULTS: A total of 170 @entity0 (90 male [53%] and 80 female [47%]), mean age 30.54  4.14 years, were evaluated. There was a significantly lower @entity5 volume in the TA group than in the placebo group (107.7  45.1 vs. 189.3  51 mL; P<0.001). There was no significant difference between pre- and postoperative hematocrit (38.81   4.20 vs. 36.60   3.35) or pre- and postoperative hemoglobin (12.51   2.5 vs. 11.64  1.9) levels in the TA group (P>0.05). Moreover, the difference between the TA and control groups regarding postoperative hematocrit (34.65  4.45 vs. 36.60  3.35) and hemoglobin (10.81  2.1vs. 11.64  1.9) levels was not significant (P>0.05). Vomiting and @entity3 in the control group was greater than in the control group, but the difference was not significant (P>0.05). We did not detect significant coagulation alterations in the TA group. CONCLUSION: TA significantly decreased @entity5 without increasing side effects such as alteration in coagulation parameters, hemodynamic changes, and @entity4 and @entity3 . Use of TA can avoid the need for antihypertensive agents to reduce @entity2 in @entity1 .

title: Impact of Intravenous XXXX on @entity5 During Endoscopic Sinus Surgery.

answer: @entity6


abstract: PURPOSE: Mid urethral sling procedures have become the surgical treatment of choice for female stress urinary @entity3 . Innovative modifications of mid urethral sling procedures were recently introduced with the claim of offering similar efficacy and decreased morbidity. We compared the efficacy and morbidity of an innovative single incision mid urethral tape and an established transobturator procedure. MATERIALS AND METHODS: We performed a prospective, randomized, controlled trial in 6 teaching hospitals in Belgium and The Netherlands between 2007 and 2009. A total of 96 @entity0 received a TVT Secur    single incision sling and 98 received a TVT    Obturator System. We collected data on @entity0 characteristics, surgery related parameters, adverse events, clinical followup, Urogenital Distress Inventory and SF-36   scores, validated questionnaires on daily life activities and visual analog scores objectifying @entity1 . Followup was 1 year. RESULTS: One-year followup was available for 75 single incision sling and 85 obturator system cases. Stress urinary @entity3 could be objectified in 16.4% of the @entity0 with a single incision sling and in 2.4% with an obturator system (p <0.05). Stress urinary @entity3 was subjectively reported by 24% of single incision sling and 8% of obturator system @entity0 (p <0.05). One year after surgery the mean    SD UDI @entity3 domain score in the single incision sling and obturator system groups was 21    24 and 13    21, respectively (p <0.01). @entity0 with a single incision sling experienced significantly less @entity1 during the first 2 weeks after surgery (p <0.05) and returned significantly earlier to normal daily activity. The OR of re-intervention for stress urinary @entity3 1 year after receiving a single incision sling vs an obturator system was 2.3 (95% CI 1.9-2.7). CONCLUSIONS: The single incision sling procedure is associated with less @entity2 and a lower objective cure rate than the obturator system procedure.

title: A randomized, controlled trial comparing an innovative single incision sling with an established transobturator sling to treat female stress urinary XXXX .

answer: @entity3


abstract: OBJECTIVES: To discover if intensive monitoring of wrist extension would produce consistent recovery curves during the subacute period, and whether any impact of additional physiotherapy could be detected. We also investigated improved approaches to statistical analysis in single-case experiments. DESIGN: A randomized multiple-baseline experiment with very frequent assessment. SETTING: @entity1 rehabilitation unit. SUBJECTS: Four @entity0 with some active wrist movement less than seven weeks after @entity1 . INTERVENTIONS: Wrist extension was measured twice daily with an electrogoniometer for 3-4 weeks. Additional upper limb physiotherapy 115 minutes, twice per day) commenced after a randomly determined period. MAIN OUTCOME MEASURES: Speed and range of wrist movement. RESULTS: A logarithmic function was fitted to the data to produce recovery curves. In all cases, active range and maximum velocity of wrist extension rose gradually over time. Mean variability in range was <5%, but with occasional outliers. Range of passive movement decreased in two cases in association with @entity2 and increased tone. There were no large improvements coinciding with additional physiotherapy but autoregression analysis indicated statistically significant changes in three cases. A randomization test confirmed an increase in active range associated with additional physiotherapy. CONCLUSIONS: Intensive electrogoniometry provided a detailed recovery pattern for each of these @entity0 . The data were surprisingly consistent over time, showing that it is feasible to use a time-series approach to investigate subacute recovery. Changes associated with additional physiotherapy were observed on some measures, demonstrating the potential of this approach for exploratory evaluation of interventions.

title: Intensive, time-series measurement of upper limb recovery in the subacute phase following XXXX .

answer: @entity1


abstract: Overexpression of soluble vascular endothelial growth factor receptor-1 has been linked to @entity4 and is thought to be secondary to @entity6 caused by @entity2 . Villous hypermaturity, characterized by presence of increased syncytial knots, has been associated with syndromes of @entity6 , particularly when severe. This study was undertaken to determine whether there is a link between soluble vascular endothelial growth factor receptor-1 expression, @entity7 , and clinical severity of @entity4 . We conducted a retrospective cohort study in which 48 placentas were selected from pathology archives ( @entity1 group). Of these, 6 had chronic @entity1 , 15 had mild @entity4 , 14 had severe @entity4 , and 13 had @entity5 , elevated liver enzymes, and @entity3 . These were compared with 55 placentas from normotensive @entity0 (control group). One representative section of placental parenchyma from each case was stained with an antibody to vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 and given a score based on extent and intensity of staining, representing expression level. Assignment of staining score was done, blinded to clinical history and pathologic diagnosis. Vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 staining was seen in placental syncytiotrophoblasts and was particularly strong in syncytial knots. There was a positive association between vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 staining score and severity of clinical @entity1 state, small placental size, and @entity7 . The association between vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 score and small placentas did not persist after controlling for hypermaturity. Vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 overexpression in the placenta strongly correlates with both severity of @entity1 and @entity7 . The correlation with @entity7 further links @entity2 to vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 production in the placenta.

title: Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical XXXX and @entity7 .

answer: @entity4


abstract: Overexpression of soluble vascular endothelial growth factor receptor-1 has been linked to @entity4 and is thought to be secondary to @entity6 caused by @entity2 . Villous hypermaturity, characterized by presence of increased syncytial knots, has been associated with syndromes of @entity6 , particularly when severe. This study was undertaken to determine whether there is a link between soluble vascular endothelial growth factor receptor-1 expression, @entity7 , and clinical severity of @entity4 . We conducted a retrospective cohort study in which 48 placentas were selected from pathology archives ( @entity1 group). Of these, 6 had chronic @entity1 , 15 had mild @entity4 , 14 had severe @entity4 , and 13 had @entity5 , elevated liver enzymes, and @entity3 . These were compared with 55 placentas from normotensive @entity0 (control group). One representative section of placental parenchyma from each case was stained with an antibody to vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 and given a score based on extent and intensity of staining, representing expression level. Assignment of staining score was done, blinded to clinical history and pathologic diagnosis. Vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 staining was seen in placental syncytiotrophoblasts and was particularly strong in syncytial knots. There was a positive association between vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 staining score and severity of clinical @entity1 state, small placental size, and @entity7 . The association between vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 score and small placentas did not persist after controlling for hypermaturity. Vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 overexpression in the placenta strongly correlates with both severity of @entity1 and @entity7 . The correlation with @entity7 further links @entity2 to vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 production in the placenta.

title: Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical @entity4 and XXXX .

answer: @entity7


abstract: OBJECTIVE: To study the effect of physical exercise shortly after an acute episode of dermato/ @entity3 ( @entity2 /PM). DESIGN: Pilot study of a descriptive nature. SETTING: Rehabilitation unit of a large general hospital. SUBJECTS: Ten @entity0 2-3 weeks after an acute phase of @entity2 /PM (early recovery group) and 11 @entity0 in the inactive stage of @entity2 /PM for at least three months (chronic stage group). INTERVENTIONS: Isotonic muscle training consisted of several series of different repeated movements at 65-70% of individual maximal repetition limit. Special training was applied for the respiratory muscles. Relaxing baths, mud packs and massages were also applied. OUTCOME MEASURES: Dynamometer and spirometer were used for measuring the changes in muscle strength and respiratory function. Disability tests were done before and after therapy. RESULTS: No disease relapses or decreases in muscle function were seen. In the early recovery group, the average muscle strength improvement was 17 +/- 31 % (p > 0.05) in the proximal muscles and 37 +/- 23% (p < 0.05) in the distal muscles, while the vital capacity also increased by 17 +/- 21% (p < 0.05). In the chronic stage group the average improvement in muscle strength was 46 +/- 34% (p < 0.05) in the proximal muscles and 37 +/- 29% (p < 0.05) in the distal muscles. By the end of the therapy both groups showed improvements in disability tests (p < 0.05). CONCLUSIONS: Physical training started 2-3 weeks following an acute exacerbation of the disease seems to be useful and safe. Some improvement in muscle strength and respiratory function can be obtained, @entity1 due to inactivity may be partially prevented and the level of disability can be decreased.

title: The effect of physical exercise following acute disease exacerbation in @entity0 with dermato/ XXXX .

answer: @entity3


abstract: OBJECTIVE: To study the effect of physical exercise shortly after an acute episode of dermato/ @entity3 ( @entity2 /PM). DESIGN: Pilot study of a descriptive nature. SETTING: Rehabilitation unit of a large general hospital. SUBJECTS: Ten @entity0 2-3 weeks after an acute phase of @entity2 /PM (early recovery group) and 11 @entity0 in the inactive stage of @entity2 /PM for at least three months (chronic stage group). INTERVENTIONS: Isotonic muscle training consisted of several series of different repeated movements at 65-70% of individual maximal repetition limit. Special training was applied for the respiratory muscles. Relaxing baths, mud packs and massages were also applied. OUTCOME MEASURES: Dynamometer and spirometer were used for measuring the changes in muscle strength and respiratory function. Disability tests were done before and after therapy. RESULTS: No disease relapses or decreases in muscle function were seen. In the early recovery group, the average muscle strength improvement was 17 +/- 31 % (p > 0.05) in the proximal muscles and 37 +/- 23% (p < 0.05) in the distal muscles, while the vital capacity also increased by 17 +/- 21% (p < 0.05). In the chronic stage group the average improvement in muscle strength was 46 +/- 34% (p < 0.05) in the proximal muscles and 37 +/- 29% (p < 0.05) in the distal muscles. By the end of the therapy both groups showed improvements in disability tests (p < 0.05). CONCLUSIONS: Physical training started 2-3 weeks following an acute exacerbation of the disease seems to be useful and safe. Some improvement in muscle strength and respiratory function can be obtained, @entity1 due to inactivity may be partially prevented and the level of disability can be decreased.

title: The effect of physical exercise following acute disease exacerbation in XXXX with dermato/ @entity3 .

answer: @entity0


abstract: @entity10 are lesions characterized by proliferation of fibroblasts/myofibroblasts with variable chronic inflammatory cell infiltration. Recent studies have suggested that @entity10 with abundant IgG4-positive plasma cells may be a unique entity associated with systemic @entity2 and should be distinguished from other similar lesions such as @entity1 and fibrohistiocytic-type @entity10 . Localized @entity10 has been rarely reported in the ureter, and IgG4-associated @entity8 has not been described. We describe herein 3 cases of ureteral @entity10 of IgG4-associated lymphoplasmacytic type, focusing on density of IgG4-positive plasma cells; infiltration pattern of eosinophils and histiocytes; presence of obliterative @entity9 ; and immunohistochemical profiles of smooth muscle actin, @entity6 kinase, and @entity5 . Three @entity0 , 45- and 47-year-old @entity0 and 84-year-old @entity0 , all presented with @entity7 and ureteral narrowing by a mass effect. Microscopic examination of the resected ureters showed suburothelial masslike lesions with fibroblasts/myofibroblasts without atypia, abundant plasma cells, and scattered eosinophils and histiocytes. The lesion of the 47-year-old @entity0 showed obliterative @entity9 in addition to the above findings. The lesion of the 84-year-old @entity0 was accompanied by @entity3 in situ in the overlying urothelium. Spindle cells were diffusely or focally positive for smooth muscle actin but negative for @entity6 kinase in all 3 cases. For each case, respectively, an average of 154, 112, and 50 plasma cells per high-power fields were immunoreactive for IgG4, a diagnostic feature of IgG4 @entity10 . We described 3 cases of IgG4-associated @entity8 with pathologic and immunohistochemical features that are compatible for lymphoplasmacytic type of @entity10 . Further study is needed to characterize any relationship between this entity and @entity4 and/or urothelial carcinogenesis.

title: IgG4-associated XXXX : clinicopathologic and immunohistochemical study of 3 cases.

answer: @entity8


abstract: Residual @entity1 , such as decreased hip muscle moment and power during walking, have been reported in @entity0 with @entity2 ( @entity2 ). Meanwhile, greater ankle power has also been reported in these @entity0 . We investigated the interaction between hip and @entity3 during walking to determine the effects of different ankle pushoff instructions on hip biomechanics in @entity0 with @entity2 . Twenty-four @entity0 (age, 60.8  5.5 years) were randomly assigned to walking exercise groups with either decreased pushoff or increased pushoff. @entity0 in the decreased pushoff group and increased pushoff group were given the instructions "push less with your foot when you walk" and "push more with your foot when you walk," respectively. Exercises lasted approximately 10-15 min. A series of gait-related parameters were analyzed during pre-exercise, exercise, and post-exercise session. In the decreased ankle pushoff group, hip flexor power absorption and hip/ankle power ratio were higher during post-exercise than during pre-exercise. An increase in hip power from -9.8% to 32.1% was identified. The effect of increase in the hip power by the decreasing ankle pushoff was higher in the @entity0 with greater ankle pushoff in their natural gaits. The @entity0 in the increased ankle pushoff group showed decreased hip flexion angle and hip muscle moment and power after the walking exercise, although ankle pushoff was not increased. Walking exercise with decreased ankle pushoff may help improve the distribution of muscle power between hip flexors and ankle plantarflexors during walking in @entity0 with @entity2 .

title: Immediate effects of different ankle pushoff instructions during walking exercise on hip kinematics and kinetics in individuals with XXXX .

answer: @entity2


abstract: OBJECTIVE: To evaluate the safety and effectiveness of novel biodegradable (BD) stents to treat @entity3 in @entity0 after lung transplantation. METHODS: Twenty BD stents were implanted endoscopically in six @entity0 (median age 41.5 years (range 35-57 years)) with post-transplant bronchial anastomotic stenoses, between 2006 and 2010. All stents were custom-made from bio-absorbable @entity5 (PDS). The median stent diameter was 12 mm (8-17 mm) and median length was 20mm (12-30 mm). All @entity0 were evaluated clinically, by bronchoscopy and high-definition computed tomography (CT). RESULTS: The @entity3 was initially relieved in all cases. There was no @entity2 , perforation or displacement after BD stent implantation. Four @entity0 needed multiple stenting for anastomotic @entity3 . Median time to any re-stenting was 5 months (2-15 months). There was one @entity4 , 1 year after the last BD stent implantation, from a @entity1 . All five survivors are in good clinical condition up to 4 years' follow-up (median 40 months, range 7-48 months) since first stenting and intervention-free up to 44 months (median 24 months, range 7-44 months). CONCLUSIONS: This small pilot study shows that BD stents are a safe, effective and reliable alternative to classical metallic stents in @entity0 with @entity3 after lung transplantation, and may avoid the need for permanent stenting.

title: Novel biodegradable stents in the treatment of XXXX after lung transplantation.

answer: @entity3


abstract: The major electrophysiological changes during the first 10 min of @entity4 caused by complete obstruction of a coronary artery are a reduction in membrane potential, a decrease in action potential amplitude and upstroke velocity, and a prolongation of recovery of excitability following an action potential. Conduction velocity in the direction parallel to the long axis of @entity2 ( @entity10 ) and in the transverse direction (VT) in normal myocardium are in the order of 40 cm/s and 20 cm/s respectively. During @entity0 , conduction velocity decreases and lowest values for @entity10 are in the order of 20 cm/s, for VT around 10 cm/s, before the ischemic tissue becomes inexcitable. Calculated dimensions of a possible re-entrant circuit in acutely ischemic myocardium (the product of refractory period and conduction velocity) are in the order of 7 to 8 cm. Re-entrant circuits of such dimensions were indeed demonstrated by simultaneous recording of 125 extracellular potentials from the epicardial surface of the ventricles during spontaneously occurring @entity5 after @entity7 . Previous studies provided evidence that premature ventricular depolarization which initiate re-entry originated in the subendocardium, and the present experiments confirmed this. Destruction of the subendocardium of isolated, Langendorff perfused @entity1 hearts, including the Purkinje system, by intracavitary application of @entity9 , did not, however, abolish ectopic activity during either @entity0 or reperfusion, although the nature of the @entity5 during @entity0 was different from those in intact hearts. Coupling intervals of ectopic beats were longer in @entity9 -treated hearts than in intact hearts, but the site of origin of initial ectopic beats leading to @entity6 could not be determined. Re-entrant circuits with revolution times in the order of 340 to 400 ms accounted for the @entity3 observed in @entity9 -treated hearts. In contrast to intact hearts, these @entity3 never degenerated into @entity8 , indicating that an intact Purkinje system may be a necessary requirement for @entity8 to occur during acute, regional @entity4 .

title: Electrophysiological basis for XXXX caused by @entity0 . Role of the subendocardium.

answer: @entity5


abstract: The major electrophysiological changes during the first 10 min of @entity4 caused by complete obstruction of a coronary artery are a reduction in membrane potential, a decrease in action potential amplitude and upstroke velocity, and a prolongation of recovery of excitability following an action potential. Conduction velocity in the direction parallel to the long axis of @entity2 ( @entity10 ) and in the transverse direction (VT) in normal myocardium are in the order of 40 cm/s and 20 cm/s respectively. During @entity0 , conduction velocity decreases and lowest values for @entity10 are in the order of 20 cm/s, for VT around 10 cm/s, before the ischemic tissue becomes inexcitable. Calculated dimensions of a possible re-entrant circuit in acutely ischemic myocardium (the product of refractory period and conduction velocity) are in the order of 7 to 8 cm. Re-entrant circuits of such dimensions were indeed demonstrated by simultaneous recording of 125 extracellular potentials from the epicardial surface of the ventricles during spontaneously occurring @entity5 after @entity7 . Previous studies provided evidence that premature ventricular depolarization which initiate re-entry originated in the subendocardium, and the present experiments confirmed this. Destruction of the subendocardium of isolated, Langendorff perfused @entity1 hearts, including the Purkinje system, by intracavitary application of @entity9 , did not, however, abolish ectopic activity during either @entity0 or reperfusion, although the nature of the @entity5 during @entity0 was different from those in intact hearts. Coupling intervals of ectopic beats were longer in @entity9 -treated hearts than in intact hearts, but the site of origin of initial ectopic beats leading to @entity6 could not be determined. Re-entrant circuits with revolution times in the order of 340 to 400 ms accounted for the @entity3 observed in @entity9 -treated hearts. In contrast to intact hearts, these @entity3 never degenerated into @entity8 , indicating that an intact Purkinje system may be a necessary requirement for @entity8 to occur during acute, regional @entity4 .

title: Electrophysiological basis for @entity5 caused by XXXX . Role of the subendocardium.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVE: The daily @entity0 flow at dental emergency departments is subject to fluctuations. The aim of the present study was to investigate whether meteorological parameters were associated with the number of @entity0 reporting acute @entity1 in the oral cavity. METHODS: We performed a retrospective review of all @entity0 presenting with acute oro-dental @entity1 (n=1090) at the dental outpatient clinic in Innsbruck, Austria from January to March 2005. In addition, local weather data were supplied by the Central Institute for Meteorology and Geodynamics Austria. After exponential smoothing of both series of observations, linear regression on the number of @entity0 was performed. RESULTS: Statistical analysis revealed that the acute @entity1 symptoms are not related to the air pressure itself but to the deviation of air pressure. The stronger the daily deviation from the average atmospheric pressure was, the more @entity0 presented with acute @entity1 at the dental emergency department (p=4.2   10(-14)). Our findings implicate that the association of air pressure deviation with variation in @entity0 flow at dental clinics is a consequence of barometric pressure-related @entity1 . CONCLUSIONS: These findings suggest that changes in barometric pressure were the reason for the observed initiation and/or exacerbation of the various oral pains observed in the emergency room setting. This association has been considered to be rare, with most reports suggesting this phenomenon primarily affects divers and aircraft personnel. Our data suggests otherwise, by providing clear evidence that atmospheric pressure changes commonly influences @entity1 .

title: Epidemiologic evidence of barometric pressure changes inducing increased reporting of XXXX .

answer: @entity1


abstract: @entity1 is usually related to @entity2 however other possible causes such as reptile exposure are often unrecognised. The aim of this study is to describe a case of @entity1 related to pet exposure. After a @entity1 in an eleven month old baby was reported to our public health agency, an epidemiological investigation took place. Despite all family members had had clinical symptoms suggesting @entity1 none of the microbiological analysis was positive. At the @entity0 's home they had an exotic pet: a turtle. We found out that Salmonella was present in a sample of water of its aquarium. Both profiles of S. parathyphi B (from the @entity0 and from the aquaria samples) were identical. Exotic pets are not often recognized as @entity1 carriers and vehicles in Europe. As described in this study, an inaccurate hygiene after touching turtles or its habitat can lead to spread @entity1 in @entity0 . When investigating @entity1 exposure to exotic pets has to be addressed. @entity0 that have or wish to have a turtle or any other reptile should be informed about its risks. Nursing role is most important in the surveillance and study of such cases.

title: [Salmonella's transmission from turtle to XXXX : public health nursing experience about a new case].

answer: @entity0


abstract: BACKGROUND: The @entity13 ( @entity13 ) is a @entity7 with a high mortality rate if untreated or delayed therapy. Whether immediate diagnosis and promptly treated with plasma exchange can change the grave prognosis? METHOD: Retrospective analysis was performed on clinical characteristics and treatment outcome of 13 @entity0 diagnosed and treated during a 6-year period, from August 1994 to August 2000, in a tertiary care university hospital in Taiwan. RESULTS: Among the @entity0 , 8 were males and 5 were females, 10 were idiopathic, 2 were @entity11 , and 1 was @entity10 -induced; 12 (92.3%) had @entity2 , 11 (84.6%) had ecchymosis, 8 (61.5%) had @entity5 , and 6 (46.2%) had @entity1 ( @entity9 > or = 1.5 mg/dL) at initial presentation of the syndrome. Excluding the @entity10 @entity0 , 6 of 10 (60%) had shown antinuclear antibody (ANA) non-specific positive (titer > or = 1:40). All @entity0 were initially treated with plasma exchange plus @entity6 . Of these 13 @entity0 , 11 (84.6%) achieved complete remission, one had partial remission, and one, which was @entity11 -induced, had no response and died of a progressive disease complicated with @entity3 . Within a median follow-up period of 31 months, 4 of 11 @entity0 who achieved complete remission relapsed after one week, two weeks, three weeks, and three months, respectively. In the four relapsing @entity0 , three late relapsing @entity0 received FFP infusion, increased @entity4 dosages, added @entity8 plus @entity12 ; and one early relapsing @entity0 , relapsing twice, received an additional two courses of plasma exchange and added @entity8 plus @entity12 . All of the four @entity0 achieved complete remission again. The @entity0 who had partial remission relapsed early and responded promptly to another course of plasma exchange plus @entity8 and @entity12 and achieved complete remission. CONCLUSION: Based on the results in this study, we conclude that plasma exchange plus @entity6 can effectively treat @entity13 . For @entity0 with a refractory or relapsing disease, immunosuppressive therapy with @entity8 plus @entity12 should be administered as well.

title: @entity13 ( @entity13 ): initial treatment with plasma exchange plus XXXX and immunosuppressive agents for relapsing cases.

answer: @entity6


abstract: BACKGROUND: The @entity13 ( @entity13 ) is a @entity7 with a high mortality rate if untreated or delayed therapy. Whether immediate diagnosis and promptly treated with plasma exchange can change the grave prognosis? METHOD: Retrospective analysis was performed on clinical characteristics and treatment outcome of 13 @entity0 diagnosed and treated during a 6-year period, from August 1994 to August 2000, in a tertiary care university hospital in Taiwan. RESULTS: Among the @entity0 , 8 were males and 5 were females, 10 were idiopathic, 2 were @entity11 , and 1 was @entity10 -induced; 12 (92.3%) had @entity2 , 11 (84.6%) had ecchymosis, 8 (61.5%) had @entity5 , and 6 (46.2%) had @entity1 ( @entity9 > or = 1.5 mg/dL) at initial presentation of the syndrome. Excluding the @entity10 @entity0 , 6 of 10 (60%) had shown antinuclear antibody (ANA) non-specific positive (titer > or = 1:40). All @entity0 were initially treated with plasma exchange plus @entity6 . Of these 13 @entity0 , 11 (84.6%) achieved complete remission, one had partial remission, and one, which was @entity11 -induced, had no response and died of a progressive disease complicated with @entity3 . Within a median follow-up period of 31 months, 4 of 11 @entity0 who achieved complete remission relapsed after one week, two weeks, three weeks, and three months, respectively. In the four relapsing @entity0 , three late relapsing @entity0 received FFP infusion, increased @entity4 dosages, added @entity8 plus @entity12 ; and one early relapsing @entity0 , relapsing twice, received an additional two courses of plasma exchange and added @entity8 plus @entity12 . All of the four @entity0 achieved complete remission again. The @entity0 who had partial remission relapsed early and responded promptly to another course of plasma exchange plus @entity8 and @entity12 and achieved complete remission. CONCLUSION: Based on the results in this study, we conclude that plasma exchange plus @entity6 can effectively treat @entity13 . For @entity0 with a refractory or relapsing disease, immunosuppressive therapy with @entity8 plus @entity12 should be administered as well.

title: XXXX ( @entity13 ): initial treatment with plasma exchange plus @entity6 and immunosuppressive agents for relapsing cases.

answer: @entity13


abstract: BACKGROUND: The @entity13 ( @entity13 ) is a @entity7 with a high mortality rate if untreated or delayed therapy. Whether immediate diagnosis and promptly treated with plasma exchange can change the grave prognosis? METHOD: Retrospective analysis was performed on clinical characteristics and treatment outcome of 13 @entity0 diagnosed and treated during a 6-year period, from August 1994 to August 2000, in a tertiary care university hospital in Taiwan. RESULTS: Among the @entity0 , 8 were males and 5 were females, 10 were idiopathic, 2 were @entity11 , and 1 was @entity10 -induced; 12 (92.3%) had @entity2 , 11 (84.6%) had ecchymosis, 8 (61.5%) had @entity5 , and 6 (46.2%) had @entity1 ( @entity9 > or = 1.5 mg/dL) at initial presentation of the syndrome. Excluding the @entity10 @entity0 , 6 of 10 (60%) had shown antinuclear antibody (ANA) non-specific positive (titer > or = 1:40). All @entity0 were initially treated with plasma exchange plus @entity6 . Of these 13 @entity0 , 11 (84.6%) achieved complete remission, one had partial remission, and one, which was @entity11 -induced, had no response and died of a progressive disease complicated with @entity3 . Within a median follow-up period of 31 months, 4 of 11 @entity0 who achieved complete remission relapsed after one week, two weeks, three weeks, and three months, respectively. In the four relapsing @entity0 , three late relapsing @entity0 received FFP infusion, increased @entity4 dosages, added @entity8 plus @entity12 ; and one early relapsing @entity0 , relapsing twice, received an additional two courses of plasma exchange and added @entity8 plus @entity12 . All of the four @entity0 achieved complete remission again. The @entity0 who had partial remission relapsed early and responded promptly to another course of plasma exchange plus @entity8 and @entity12 and achieved complete remission. CONCLUSION: Based on the results in this study, we conclude that plasma exchange plus @entity6 can effectively treat @entity13 . For @entity0 with a refractory or relapsing disease, immunosuppressive therapy with @entity8 plus @entity12 should be administered as well.

title: @entity13 ( XXXX ): initial treatment with plasma exchange plus @entity6 and immunosuppressive agents for relapsing cases.

answer: @entity13


abstract: @entity0 prostatic acid phosphatase isoenzyme 2 (HPAcP-2) was isolated from semen. This purified enzyme was immunized to @entity2 to produce polyclonal antibodies. The specificity of the antibodies was tested by Western blot transfer method. Rabbit IgG-peroxidase conjugate was prepared from the antiserum and used to localize HPAcP-2 in @entity3 . It was found that in the @entity1 glandular acinus the normal basal cells were replaced by @entity1 cells containing reaction product. In the @entity1 cells, the reaction product was seen in the cisternae of rough endoplasmic reticulum (ER) and Golgi apparatus. The secretory vesicles which contained reaction product-stained granules and some amorphous material were seen to fuse with the apical plasma membrane and discharged their content into the glandular lumen. On the other hand, some secretory vesicles in the @entity1 cells facing to the basement membrane also discharged their similar content into the extracellular spaces. Reaction product-stained granules were found in the interstitial spaces surrounding the @entity1 cells. These findings suggest that HPAcP-2 is synthesized on the bound ribosomes and discharged into the cisternae of rough ER. The molecules are transported to the Golgi cisternae. After concentration and packaging, HPAcP-2 molecules are then transferred to the secretory vesicles, and discharged into the glandular lumen and to the extracellular spaces. The isoenzyme released in the extracellular space may reach the blood stream through the interstitial spaces or the lymphatic system, resulting in the elevation of serum HPAcPase level in some @entity3 @entity0 .

title: Immunoultrastructural demonstration of prostatic acid phosphatase isoenzyme 2 in XXXX .

answer: @entity3


abstract: OBJECTIVE: To perform a systematic review of exercise trials post @entity1 . DESIGN: A systematic review of controlled clinical trials. SEARCH STRATEGY: MEDLINE, EMBASE, CINAHL, Amed, Sports Discus, Cochrane controlled trials register and PEDro were searched for relevant trials. INCLUSION CRITERIA: Studies--randomized or quasi-randomized controlled clinical trials. @entity0 --Adults of any age with a clinical diagnosis of @entity1 . Interventions--Any @entity2 intervention aimed at improving @entity2 and/or function. OUTCOMES: Impairment: gait speed, strength, endurance, balance, flexibility, tonus and exercise capacity. Disability: global dependency, functional independence. Extended activities of daily living. Quality of life. @entity3 . DATA COLLECTION AND ANALYSIS: Two independent reviewers categorized selected trials, documented the methodological quality and extracted the relevant data. Comparisons of @entity2 interventions versus no cardiovascular intervention were made. Statistical comparisons were carried out using a random effects model to calculate standardized mean differences. RESULTS: We identified three eligible trials. Small numbers and heterogeneous outcomes limited the analyses and comparisons. Based on the limited data available, we found that @entity2 post @entity1 was no better than no exercise with respect to disability, impairment, extended activities of daily living, quality of life and @entity3 . CONCLUSION: Insufficient evidence was identified to establish if @entity2 has a positive effect on disability, impairment, extended activities of daily living, quality of life and case fatality post @entity1 .

title: A systematic review of exercise trials post XXXX .

answer: @entity1


abstract: @entity3 ( @entity3 ) is the most common reason for acute admission to hospital and the fourth most common cause of @entity2 in the UK. It is important to identify @entity0 with severe @entity1 and the worst prognosis. We conducted this study to validate a rule designed to do this devised in New Zealand. @entity3 was defined by evidence of new shadowing on the chest X-ray and clinical features of @entity1 . A standardised proforma was completed documenting clinical features and investigation results. Severe @entity1 was identified by two or more of the following: @entity4 ; respiratory rate > or = 30/min; diastolic blood pressure < or = 60 mmHg; @entity5 >7 mmol/l. One hundred @entity0 (mean age 58.8 years) were included; 32 satisfied the rule. Seven died, all of whom satisfied the rule. Ten @entity0 received intensive care, including six who died. Of 11 @entity0 who died and/or received intensive care, nine satisfied the rule. The sensitivity and specificity of the rule for predicting @entity2 and/or intensive care were 82% and 73% respectively.

title: Recognising severe XXXX with simple clinical and biochemical measurements.

answer: @entity1


abstract: INTRODUCTION: @entity6 ( @entity6 ) is the leading indication for orthotopic liver transplantation (OLT) among @entity0 . However, there are technical difficulties, including the limited dimensions of anatomical structures, @entity2 and/or @entity3 of the portal vein and previous portoenterostomy procedures. OBJECTIVE: The objective of this study was to present our experience of 239 @entity0 with @entity6 who underwent OLT between September 1989 and June 2010 compared with OLT performed for other causes. METHODS: We performed a retrospective analysis of @entity0 charts and analysis of complications and survival. RESULTS: @entity6 was the most common indication for OLT (207/409; 50.6%). The median age of subjects was 26 months (range, 7-192). Their median weight was 11 kg (range, 5-63) with 110 @entity0 (53.1%) weighing  <=10 kg. We performed 126 transplantations from cadaveric donors (60.8%) and 81 from living-related donors (LRD) (39.2%). Retransplantation was required for 31 recipients (14.9%), primarily due to @entity3 ( @entity3 ; 64.5%). Other complications included the following: @entity3 ( @entity3 ; 13.0%), @entity4 and/or @entity1 (22.2%), bowel perforation (7.0%), and @entity5 ( @entity5 ; 5.3%). Among the cases of OLT for other causes, the median age of recipients was 81 months (range, 11-17 years), which was higher than that for @entity0 with @entity6 . Retransplantation was required in 3.5% of these @entity0 (P < .05), mostly due to @entity3 . The incidences of @entity3 , and @entity5 were significantly lower (P < .05). There was no significant difference between biliary complications in the 2 groups. The overall survival rates at 1 versus 5 years were 79.7% versus 68.1% for @entity6 , and 81.2% versus 75.7% for other causes, respectively. CONCLUSIONS: @entity0 who undergo OLT for @entity6 are younger than those engrafted for other causes, displaying a higher risk of complications and retransplantations.

title: Orthotopic liver transplantation in XXXX : a single-center experience.

answer: @entity6


abstract: BACKGROUND: National renal registry studies providing data for incidence, prevalence, and characteristics of @entity6 and renal replacement therapy (RRT) serve as a basis to determine national strategies for the prevention and treatment of these diseases and identify new areas for special studies. STUDY DESIGN: Since 1990, the Turkish Society of Nephrology has been coordinating a national renal registry that collects data on @entity0 receiving RRT. This report focuses on data collected from 1996-2008. SETTING _ @entity0 : Data were collected in dialysis centers for @entity0 on RRT. PREDICTOR: Year. OUTCOMES: Point prevalence and incidence of RRT, RRT modalities, demographic and clinical characteristics of @entity0 on RRT. RESULTS: From 1996 to 2008, the number of centers (199 and 760) and response rates to the registry (76% and 99.4%) increased. In 2008, the point prevalence of RRT was 756 per million population (pmp) and incidence was 188 pmp, including pediatric @entity0 . In prevalent @entity0 , the most common RRT modality was hemodialysis (77.0% of @entity0 ), followed by peritoneal dialysis (10.1%) and transplant (12.9%). The age of hemodialysis and transplant @entity0 increased, with a predominance of male @entity0 . Percentages of @entity1 and @entity2 as causes of @entity6 increased, whereas those of chronic @entity7 and @entity8 decreased. Infection and crude @entity3 rates decreased in all treatment modalities. LIMITATIONS: The main study limitations were registry design and low number of kidney transplants. CONCLUSION: With increasing numbers of dialysis centers and RRT @entity0 during the last 12 years, the need for RRT in @entity4 has been better met. The quality of RRT care has improved, especially regarding prevention and treatment of @entity5 .

title: Trends in renal replacement therapy in XXXX , 1996-2008.

answer: @entity4


abstract: Although @entity0 with @entity4 are at increased risk for @entity2 , the type and rate of these problems differ between those with different causes for their retardation. In this paper, we review behavioural and @entity2 problems in @entity0 with @entity8 , @entity1 caused by a paternally derived deletion at chromosome 15(q11-q13) in about 70% of affected @entity0 , and by @entity10 in the majority of the remaining @entity0 . In addition to the syndrome's characteristic @entity9 and food seeking, individuals with @entity8 also have increased risks of nonfood, compulsive behaviours. These include skin picking, which is highly prevalent, as well as more variable rates of hoarding, redoing and concerns with symmetry, exactness, cleanliness, ordering and arranging. Relative to others with @entity6 , @entity0 with @entity8 are at a marked increased risk for developing full-blown, @entity7 . In addition, many @entity0 with @entity8 show increased rates of tantrums, oppositionality and @entity2 . Recent findings suggest that they also have an increased risk of @entity5 or affective illness with a @entity3 component, especially young adult @entity0 and those with the @entity10 as opposed to paternal deletion. Dietary approaches include a reduced-calorie diet and increased physical activity, as well as close supervision around food and keeping food locked away. To date, neither CNS stimulants nor anorectic agents have been effective in treating @entity9 , in part because @entity9 in @entity8 is attributed to decreased satiation as opposed to increased hunger. Treatment for @entity7 and maladaptive behaviours include: behavioural programming; a structured, predictable routine; extra help with transitions; family support; and pharmacotherapy. Although formal drug studies have yet to be conducted, SSRIs have been effective in reducing skin picking, @entity7 and @entity2 episodes in some individuals with @entity8 . Atypical antipsychotics have also proven helpful in @entity0 with @entity2 and impulsivity. Largely on the basis of case studies, the risks and benefits of these and other drugs in @entity8 are reviewed. Drug trials that move beyond case studies and that assess the relative efficacy of behavioural treatments alone or in combination with pharmacotherapy are sorely needed.

title: @entity2 in XXXX : epidemiology and management.

answer: @entity8


abstract: Although @entity0 with @entity4 are at increased risk for @entity2 , the type and rate of these problems differ between those with different causes for their retardation. In this paper, we review behavioural and @entity2 problems in @entity0 with @entity8 , @entity1 caused by a paternally derived deletion at chromosome 15(q11-q13) in about 70% of affected @entity0 , and by @entity10 in the majority of the remaining @entity0 . In addition to the syndrome's characteristic @entity9 and food seeking, individuals with @entity8 also have increased risks of nonfood, compulsive behaviours. These include skin picking, which is highly prevalent, as well as more variable rates of hoarding, redoing and concerns with symmetry, exactness, cleanliness, ordering and arranging. Relative to others with @entity6 , @entity0 with @entity8 are at a marked increased risk for developing full-blown, @entity7 . In addition, many @entity0 with @entity8 show increased rates of tantrums, oppositionality and @entity2 . Recent findings suggest that they also have an increased risk of @entity5 or affective illness with a @entity3 component, especially young adult @entity0 and those with the @entity10 as opposed to paternal deletion. Dietary approaches include a reduced-calorie diet and increased physical activity, as well as close supervision around food and keeping food locked away. To date, neither CNS stimulants nor anorectic agents have been effective in treating @entity9 , in part because @entity9 in @entity8 is attributed to decreased satiation as opposed to increased hunger. Treatment for @entity7 and maladaptive behaviours include: behavioural programming; a structured, predictable routine; extra help with transitions; family support; and pharmacotherapy. Although formal drug studies have yet to be conducted, SSRIs have been effective in reducing skin picking, @entity7 and @entity2 episodes in some individuals with @entity8 . Atypical antipsychotics have also proven helpful in @entity0 with @entity2 and impulsivity. Largely on the basis of case studies, the risks and benefits of these and other drugs in @entity8 are reviewed. Drug trials that move beyond case studies and that assess the relative efficacy of behavioural treatments alone or in combination with pharmacotherapy are sorely needed.

title: XXXX in @entity8 : epidemiology and management.

answer: @entity2


abstract: BACKGROUND: Infertility is a growing problem in western societies. Few studies have examined the drug utilization of common treatments for @entity1 . @entity2 (CC) is the first-line treatment for normogonadotropic @entity0 with absent or irregular ovulation. We examined CC use among @entity0 at reproductive age in the northern Netherlands. METHODS: Drug dispensing data of CC between 1998 and 2007 were retrieved from the IADB.nl database. Two-year prevalences of CC use per 1000 @entity0 covered by the database were calculated and stratified by 5-year age group. The duration of CC use was analyzed using Kaplan-Meier survival analysis. RESULTS: From the IADB.nl database, a total of 1854 @entity0 aged 20-44 years initiated ovulation induction treatment with CC only in the northern Netherlands during 1998 and 2007. The 2-year prevalence of CC use increased from 6.66 per 1000 @entity0 during 1998-1999 to 7.24 per 1000 during 2002-2003, followed by a decrease to 4.82 per 1000 in 2006-2007 (P < 0.05). Median duration of CC use was four cycles for @entity0 <30 years of age, three cycles for @entity0 aged 30-39 and two cycles for @entity0 aged above 40. CONCLUSIONS: There is no increase of CC use during 1998-2007, and indeed a decrease of CC use during recent years, among @entity0 at reproductive age in northern Netherlands.

title: XXXX utilization in the Netherlands 1998-2007.

answer: @entity2


abstract: Dendritic cells are professional antigen-presenting cells that are specialized in antigen uptake and presentation. @entity5 to cat has increased substantially in recent years and has been shown to be positively associated with @entity4 . We have recently shown that the @entity7 receptor (MR), a C-type lectin expressed by dendritic cells, recognizes various glycoallergens from diverse sources and is involved in promoting @entity2 responses to a major house dust mite allergen in vitro. Here we investigated the potential role of MR in @entity2 responses to Fel d 1, a major cat allergen. Fel d 1 binding to MR was confirmed by ELISA. Using blocking, gene silencing (siRNA) experiments, and MR knock-out (MR(-/-)) cells, we have demonstrated that MR plays a major role in internalization of Fel d 1 by @entity0 and mouse antigen-presenting cells. Intriguingly, unlike other glycoallergens, recognition of Fel d 1 by MR is mediated by the @entity3 -rich domain, which correlates with the presence of sulfated @entity6 in natural Fel d 1. WT and MR(-/-) @entity1 were used to study the role of MR in @entity2 sensitization to Fel d 1 in vivo. MR(-/-) @entity1 sensitized with cat dander extract and Fel d 1 produced significantly lower levels of total IgE, Fel d 1-specific-IgE and @entity8 , the hallmarks of @entity2 response, compared with WT @entity1 . Our data show for the first time that Fel d 1 is a novel ligand of the @entity3 -rich domain of MR and that MR is likely to play a pivotal role in @entity2 sensitization to airborne allergens in vivo.

title: Recognition of the major cat allergen Fel d 1 through the @entity3 -rich domain of the XXXX receptor determines its allergenicity.

answer: @entity7