abstract: PURPOSE: The aim of this study was to investigate feasibility of exercise-based rehabilitation delivered after hospital discharge in @entity0 with intensive care unit-acquired weakness (ICU-AW). MATERIALS AND METHODS: Twenty adult @entity0 , mechanically ventilated for more than 48 hours, with ICU-AW diagnosis at ICU discharge were included in a pilot feasibility randomized controlled trial receiving a 16-session exercise-based rehabilitation program. Twenty-one @entity0 without ICU-AW participated in a nested observational cohort study. Feasibility, clinical, and @entity0 -centered outcomes were measured at hospital discharge and at 3 months. RESULTS: Intervention feasibility was demonstrated by high adherence and @entity0 acceptability, and absence of adverse events, but this must be offset by the low proportion of enrolment for those screened. The study was underpowered to detect effectiveness of the intervention. The use of manual muscle testing for the diagnosis of ICU-AW lacked robustness as an eligibility criterion and lacked discrimination for identifying rehabilitation requirements. Process evaluation of the trial identified methodological factors, categorized by "population," "intervention," "control group," and "outcome." CONCLUSIONS: Important data detailing the design, conduct, and implementation of a multicenter randomized controlled trial of exercise-based rehabilitation for survivors of @entity1 after hospital discharge have been reported. REGISTRATION: Clinical Trials Identifier NCT00976807.

title: Exercise-based rehabilitation after hospital discharge for survivors of XXXX with intensive care unit-acquired weakness: A pilot feasibility trial.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Reperfusion-associated @entity4 ( @entity4 ) is an important complication of recanalization therapy. A method to identify @entity3 victims that may undergo @entity4 will improve the @entity0 selection and safety of this treatment. In this study, we determined the relationship between timing of reperfusion and the frequency and severity of @entity4 , and whether very early dynamic contrast-enhanced (DCE) imaging predicts the occurrence of reperfusion-associated @entity4 in a model of experimental @entity3 . METHODS: Intraluminal suture occlusion of the middle cerebral artery was used to produce transient @entity2 in male @entity1 (n = 50). Reperfusion was performed by withdrawal of the occluding filament after 3 (n = 10), 4 (n = 10), 5 (n = 10), 6 (n = 10), or 7 (n = 10) hours. Magnetic resonance imaging studies were performed before reperfusion using DCE, susceptibility-weighted imaging, diffusion-weighted imaging, and T2- and T1-weighted imaging. Follow-up magnetic resonance imaging and histological studies were performed at 24 hours. RESULTS: Hemorrhagic transformation occurred by 24 hours after injury in 8 of 50 animals. The @entity4 rate increased with prolonged @entity2 duration. All animals exhibiting acute blood-brain barrier (BBB) perturbation subsequently developed @entity4 by 24 hours. Statistically significant differences in the BBB permeability parameters (P < 0.05) between the @entity4 group and non- @entity4 group were detected by DCE imaging. There were also statistically significant differences (P < 0.05) between the @entity4 area and adjacent @entity4 area. Among the permeability parameters, subcortex rK was the most sensitive and specific predictor of @entity4 . CONCLUSIONS: The results suggest that the use of quantitative BBB measurements may further improve early prediction and identification of @entity4 . The DCE parameters were the sensitive early independent predictor of reperfusion-associated @entity4 .

title: Prediction of Reperfusion-Associated Hemorrhagic Transformation Using Dynamic Contrast-Enhanced Imaging in a @entity1 XXXX Model.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: Reperfusion-associated @entity4 ( @entity4 ) is an important complication of recanalization therapy. A method to identify @entity3 victims that may undergo @entity4 will improve the @entity0 selection and safety of this treatment. In this study, we determined the relationship between timing of reperfusion and the frequency and severity of @entity4 , and whether very early dynamic contrast-enhanced (DCE) imaging predicts the occurrence of reperfusion-associated @entity4 in a model of experimental @entity3 . METHODS: Intraluminal suture occlusion of the middle cerebral artery was used to produce transient @entity2 in male @entity1 (n = 50). Reperfusion was performed by withdrawal of the occluding filament after 3 (n = 10), 4 (n = 10), 5 (n = 10), 6 (n = 10), or 7 (n = 10) hours. Magnetic resonance imaging studies were performed before reperfusion using DCE, susceptibility-weighted imaging, diffusion-weighted imaging, and T2- and T1-weighted imaging. Follow-up magnetic resonance imaging and histological studies were performed at 24 hours. RESULTS: Hemorrhagic transformation occurred by 24 hours after injury in 8 of 50 animals. The @entity4 rate increased with prolonged @entity2 duration. All animals exhibiting acute blood-brain barrier (BBB) perturbation subsequently developed @entity4 by 24 hours. Statistically significant differences in the BBB permeability parameters (P < 0.05) between the @entity4 group and non- @entity4 group were detected by DCE imaging. There were also statistically significant differences (P < 0.05) between the @entity4 area and adjacent @entity4 area. Among the permeability parameters, subcortex rK was the most sensitive and specific predictor of @entity4 . CONCLUSIONS: The results suggest that the use of quantitative BBB measurements may further improve early prediction and identification of @entity4 . The DCE parameters were the sensitive early independent predictor of reperfusion-associated @entity4 .

title: Prediction of Reperfusion-Associated Hemorrhagic Transformation Using Dynamic Contrast-Enhanced Imaging in a XXXX @entity3 Model.

answer: @entity1


abstract: OBJECTIVE: This report describes three @entity0 with @entity3 who were treated in the United States and developed for severe @entity4 and @entity2 . The @entity0 received mechanical ventilation, renal replacement therapy, invasive monitoring, vasopressor support, and investigational therapies for @entity3 . DATA SOURCES: @entity0 medical records from three tertiary care centers (Emory University Hospital, University of Nebraska Medical Center, and Texas Health Presbyterian Dallas Hospital). STUDY SELECTION: Not applicable. DATA EXTRACTION: Not applicable. DATA SYNTHESIS: Not applicable. CONCLUSION: In the severe form, @entity0 with @entity3 may require life-sustaining therapy, including mechanical ventilation and renal replacement therapy. In conjunction with other reported cases, this series suggests that respiratory and @entity1 may occur in severe @entity3 , especially in @entity0 burdened with high viral loads. @entity3 complicated by @entity2 can be survivable with the application of advanced life support measures. This collective, multicenter experience is presented with the hope that it may inform future treatment of @entity0 with @entity3 requiring critical care treatment.

title: Critical Care for Multiple Organ Failure Secondary to XXXX in the United States.

answer: @entity3


abstract: BACKGROUND AND AIMS: @entity4 ( @entity4 ) or @entity5 is most commonly seen in @entity3 and is associated with significant morbidity and mortality. Several small case series have suggested a role for hyperbaric oxygen therapy (HBOT) in the treatment of this condition. The aim of this study was to determine whether HBOT is effective in @entity5 lesions and to determine if there are any @entity0 factors which can predict wound healing and @entity0 survival. METHODS: We identified by retrospective review all cases of @entity4 referred to our institution for treatment with HBOT. We documented the clinical and biochemical parameters of this @entity0 population, the size and distribution of the lesions as well as wound outcomes and @entity0 survival following treatment. RESULTS: A total 46 @entity0 were identified with @entity4 associated with @entity2 . Of the 46 @entity0 , only 34 received a full course of HBOT. The balance were deemed unsuitable for treatment or were unable to tolerate treatment and were palliated. Of the 34 @entity0 that received a full course of HBOT, 58% showed improvement in their wound scores, with more than half of these @entity0 having complete healing of their wounds. The balance did not benefit from the therapy and had a very poor prognosis with most dying within 12 months of referral. Those that benefited from HBOT survived on average for more than 3 years. The only factor significantly associated with improved wound healing and survival was @entity1 . CONCLUSION: In an area where clinical trials are very difficult to perform, this retrospective analysis suggests a role for HBOT in the treatment of @entity4 with more than half of the treated @entity0 benefiting and surviving for on average more than 3 years.

title: Hyperbaric Oxygen in the Treatment of XXXX : A case series and literature review.

answer: @entity5


abstract: OBJECTIVES: To analyse the @entity1 exposure characteristics and @entity2 trend in textile workers operating in the larger Tuscan textile industrial province of Prato between 1988 and 2012. METHODS: All cases of textile workers recorded by the Tuscan @entity2 register are considered. The demographic and clinical characteristics and @entity1 exposure of cases working in the province of Prato are examined. Crude incidence rates between 1988 and 2012 and their 95% confidence intervals (CI) are calculated in rag sorters and other textile workers. The trends of standardized rates are also evaluated, as well as the sources of occupational @entity1 exposure from occupational histories of cases affected by other @entity0 in rag sorters. RESULTS: One hundred and seventy-two @entity3 ( @entity3 ) have been diagnosed in textile workers in Tuscany. Among these, 46.5% were residents in the province of Prato at the time of diagnosis, half of whom working as rag sorters. All rag sorters with MM are classified as occupationally @entity1 exposed, while 71.7% are other textile workers exposed to @entity1 . The estimated crude incidence rate in rag sorters in Prato ranges from 74.1*100000 (95% CI: 52.5-101.8) to 166.8*100000 (95% CI: 118.1-229.0). The standardized rates in Prato rag sorters appeared higher throughout the 1990s while in other Prato textile workers the rates increased later on, at the very end of the 1990s. Another 40 cases of @entity0 in rag sorters were also collected. CONCLUSIONS: A very high incidence of @entity3 was observed in textile workers in Prato, especially among rag sorters. This result, together with the high number of other @entity0 in rag sorters, strongly supports the hypothesis of diffuse @entity1 exposure in rag sorting, in the absence of any other relevant aetiological factor for @entity3 .

title: XXXX in Textile Rag Sorters.

answer: @entity3


abstract: BACKGROUND: @entity8 ( @entity8 ) is a disorder characterized by vascular compression of the duodenum leading to mechanical obstruction. Surgical intervention is indicated in @entity0 who fail standard non-operative management, in which duodenojejunostomy is favored based on previous small series. Given the rarity of the condition, knowledge of the optimal indications for surgery, risk of @entity2 , and prognosis of @entity8 after minimally invasive duodenojejunostomy is limited. METHODS: A retrospective chart review was performed on @entity0 who underwent minimally invasive duodenojejunostomy for @entity8 from March 2005 to December 2013 at our "healthcare system". We analyzed @entity0 ' presentations, work-up, surgical therapy, and outcomes. RESULTS: A series of 14 @entity0 with @entity8 underwent minimally invasive duodenojejunostomy. All of these @entity0 met clinical criteria of @entity8 with radiological confirmation. Average @entity5 before surgery was 10.7  kg. @entity4 were comorbid in 6/14 @entity0 . The mean age was 39  years (19-91  years). Twelve operations were completed laparoscopically and two were performed with robotic assistance. Mean operation duration was 119  min and average length of hospital stay was 5.5  days. There were no immediate @entity2 . One @entity0 developed a delayed  anastomotic stricture that improved with single @entity6 . Initial symptom improvement occurred in all @entity0 and the improvement occurred in 11 @entity0 (79  %) during the follow-up. At a mean follow-up of 20  months, two @entity0 experienced complications, including one @entity3  at a simultaneously placed J-tube site and one @entity0 with dumping syndrome. Mean weight gain was 3.8  kg (p  <  0.01). CONCLUSION: @entity8 should be considered a potential diagnosis in @entity0 who present with a history of @entity7 , @entity1 , and @entity5 and confirmatory radiographic findings. In well-selected @entity0 , minimally invasive duodenojejunostomy is a safe and effective treatment for @entity8 with excellent short-term outcomes.

title: Minimally invasive duodenojejunostomy for superior XXXX : a case series and review of the literature.

answer: @entity8


abstract: UNASSIGNED: Wilson, PB. Ginger (Zingiber officinale) as an analgesic and ergogenic @entity7 in sport: a systemic review. J Strength Cond Res 29(10): 2980-2995, 2015-Ginger is a popular spice used to treat a variety of maladies, including @entity2 . Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used by athletes to manage and prevent @entity2 ; unfortunately, NSAIDs contribute to substantial adverse effects, including @entity3 , exercise-induced bronchoconstriction, @entity6 , impairment of connective tissue remodeling, endurance competition withdrawal, and @entity1 . Ginger, however, may act as a promoter of GI integrity and as a bronchodilator. Given these potentially positive effects of ginger, a systematic review of randomized trials was performed to assess the evidence for ginger as an analgesic and ergogenic @entity7 for exercise training and sport. Among 7 studies examining ginger as an analgesic, the evidence indicates that roughly 2 g  d of ginger may modestly reduce @entity4 stemming from eccentric resistance exercise and prolonged @entity8 , particularly if taken for a minimum of 5 days. Among 9 studies examining ginger as an ergogenic @entity7 , no discernable effects on body composition, metabolic rate, @entity0 consumption, isometric force generation, or perceived exertion were observed. Limited data suggest that ginger may accelerate recovery of maximal strength after eccentric resistance exercise and reduce the inflammatory response to @entity9 . Major limitations to the research include the use of untrained individuals, insufficient reporting on adverse events, and no direct comparisons with NSAID ingestion. While ginger taken over 1-2 weeks may reduce @entity2 from eccentric resistance exercise and prolonged @entity8 , more research is needed to evaluate its safety and efficacy as an analgesic for a wide range of @entity5 endeavors.

title: Ginger (Zingiber officinale) as an Analgesic and Ergogenic XXXX in Sport: A Systemic Review.

answer: @entity7


abstract: UNASSIGNED: The porphyrias are a group of inherited @entity6 resulting from enzymatic deficiencies of specific haem biosynthetic enzymes. They can be classified as primarily acute and non-acute types. Clinically, the acute @entity4 (AHPs) are characterised by acute neurovisceral attacks. @entity1 with AHP may be at increased risk for development of @entity5 ( @entity5 ). However, systematic studies on the occurrence of other @entity3 in @entity1 with the AHPs have not been performed to date. Here, we studied the development of @entity5 and distinct @entity3 in @entity1 with the AHPs registered in a single European porphyria specialist centre. A questionnaire was designed and sent to all individuals (n = 122) diagnosed between 1970 and 2012 of whom a valid address was available (n = 82), requesting information on their personal and family history of @entity3 . Statistical analysis was performed to calculate incidence, prevalence and relative risk of @entity5 . To calculate confidence intervals, a Poisson distribution was assumed. Forty-nine @entity1 (59.8%) returned a completed questionnaire. Overall, @entity5 was diagnosed in one female (2.1%), and the remaining @entity1 reported on six distinct @entity3 . We were able to confirm that @entity5 is an important complication in AHP. The @entity1 in our cohort had an approximately 35-fold increased risk of developing @entity5 , similar to observations in other European countries. In addition, we detected @entity0 as well as @entity7 and a liver @entity2 in @entity1 with AHP. However, considering the small number of @entity3 and @entity1 studied here, the data should be interpreted with caution, and further studies on @entity3 occurrence in AHP @entity1 will require a multicentre setting.

title: Occurrence of @entity3 in the Acute XXXX .

answer: @entity4


abstract: UNASSIGNED: The porphyrias are a group of inherited @entity6 resulting from enzymatic deficiencies of specific haem biosynthetic enzymes. They can be classified as primarily acute and non-acute types. Clinically, the acute @entity4 (AHPs) are characterised by acute neurovisceral attacks. @entity1 with AHP may be at increased risk for development of @entity5 ( @entity5 ). However, systematic studies on the occurrence of other @entity3 in @entity1 with the AHPs have not been performed to date. Here, we studied the development of @entity5 and distinct @entity3 in @entity1 with the AHPs registered in a single European porphyria specialist centre. A questionnaire was designed and sent to all individuals (n = 122) diagnosed between 1970 and 2012 of whom a valid address was available (n = 82), requesting information on their personal and family history of @entity3 . Statistical analysis was performed to calculate incidence, prevalence and relative risk of @entity5 . To calculate confidence intervals, a Poisson distribution was assumed. Forty-nine @entity1 (59.8%) returned a completed questionnaire. Overall, @entity5 was diagnosed in one female (2.1%), and the remaining @entity1 reported on six distinct @entity3 . We were able to confirm that @entity5 is an important complication in AHP. The @entity1 in our cohort had an approximately 35-fold increased risk of developing @entity5 , similar to observations in other European countries. In addition, we detected @entity0 as well as @entity7 and a liver @entity2 in @entity1 with AHP. However, considering the small number of @entity3 and @entity1 studied here, the data should be interpreted with caution, and further studies on @entity3 occurrence in AHP @entity1 will require a multicentre setting.

title: Occurrence of XXXX in the Acute @entity4 .

answer: @entity3


abstract: UNASSIGNED: @entity7 ( @entity7 ) is expressed on several malignant @entity2 of neuroendocrine origin, including @entity4 . In this study, we investigated the therapeutic efficacy of @entity2 -directed T-cell responses, elicited by @entity7 -retargeted oncolytic @entity9 , in an orthotopic @entity3 model of disseminated @entity1 . In several cell lines, we demonstrated highly @entity7 -selective retargeting of @entity5 using a bispecific adapter comprising the ectodomain of the coxsackievirus/adenovirus receptor and a @entity7 -recognizing single-chain antibody domain. PolySia-dependent @entity5 in vivo facilitated effective uptake of viruses in subcutaneous @entity7 -expressing @entity0 @entity2 , whereas hepatic viral load and hepatotoxicity were significantly reduced. The impact and nature of antitumoral immune responses triggered by systemic delivery of @entity7 -retargeted oncolytic adenoviruses were investigated in an orthotopic model of disseminated @entity1 . Interestingly, improved transduction by @entity7 -retargeted oncolytic adenoviruses led to @entity8 -positive cell infiltrates in close association with large lytic areas. Consistently, enhanced @entity2 regression and prolonged survival was only observed in immunocompetent @entity3 , but not in @entity6 @entity3 . To investigate whether improved @entity5 by @entity7 retargeting would elicit a @entity2 -specific T-cell response, we screened the used @entity1 cells for mutated oncogenes by complete exon sequencing. In agreement with our other results, only retargeted oncolysis was able to induce a significant response specific for the @entity2 -associated neoepitope Gsta2-Y9H. In conclusion, we demonstrated that effective retargeting of oncolytic adenovirus against @entity7 -expressing @entity2 elicits an effective @entity2 -directed T-cell response after systemic virus delivery and facilitates therapy of disseminated @entity1 . Cancer Immunol Res; 3(7); 1-13.   2015 AACR.

title: PolySia-Specific Retargeting of Oncolytic Viruses Triggers Tumor-Specific Immune Responses and Facilitates Therapy of Disseminated XXXX .

answer: @entity1


abstract: Glycogen synthase kinase 3 (GSK3) is a constitutively active regulatory enzyme that is important in @entity0 , @entity1 , and @entity3 . While @entity12 is usually important in neurodegenerative and @entity4 @entity10 is fundamental in the inflammatory response caused by bacterial components. Peptidoglycan (PGN), one of the most abundant cell-wall structures of Gram-positive bacteria, is an important inducer of @entity2 . To evaluate whether inhibition of @entity12 and @entity10 activity in @entity6 endothelial cells (BEC) regulates the expression of the pro-inflammatory cytokine @entity11 , we treated BEC with @entity5 -purified PGN from @entity7 . We found that PGN triggered a TLR2/PI3K/Akt-dependent phosphorylation of @entity12 at Ser21, @entity10 at Ser9, and NF-kB p65 subunit (p65) at Ser536, and the phosphorylation of @entity12 was consistently higher than that of @entity10 . The expression of @entity11 was inhibited in BEC stimulated with PGN and pre-treated with a specific neutralizing anti-TLR2 antibody that targets the extracellular domain of TLR2 or by the addition of Akt-i IV (an Akt inhibitor). Inhibition of @entity12 and @entity10 with @entity8 or @entity9 induced an increase in @entity11 mRNA and protein. The effect of each isoform on @entity11 expression was evaluated by siRNA-gene expression silencing of @entity12 and @entity10 . @entity12 gene silencing resulted in a marked increase in @entity11 mRNA and protein while @entity10 gene silencing had the opposite effect on @entity11 expression. These results indicate that the TLR2/PI3K/Akt-dependent inhibition of @entity12 activity also plays an important role in the inflammatory response caused by stimulation of BEC with PGN from @entity7 .

title: The Glycogen Synthase Kinase 3a and b Isoforms Differentially Regulates Interleukin-12p40 Expression in Endothelial Cells Stimulated with Peptidoglycan from XXXX .

answer: @entity7


abstract: The aim of the study was to develop a short questionnaire for classifying @entity0 according to their use of salt in public health work. After pretesting the questionnaire it was modified to measure the saltiness of diet. It consisted of five questions concerning certain salting habits and self-rating of salt use, and the frequency of use of seven salty food items. The questionnaire was completed by 1471 @entity0 aged 14 to 65 who also collected one 24-hour urine sample. A sum index of all the questions was formed and called the Salt Index (SI). The correlation between the 24-hour urinary @entity1 excretion and SI was 0.18 in @entity0 and 0.20 in @entity0 (both significant at p less than 0.001). @entity0 and @entity0 were classified into three groups according to their SI: low representing the lowest quintile, high representing the highest and medium containing all the other quintiles. The mean 24-hour urinary @entity1 excretion was lowest in the low SI-category and highest in the high SI-category in both @entity0 and @entity0 . The subjects were further divided into light and heavy workers on the basis of their occupation. In this analysis the effect of both energy intake and the saltiness of the diet indicated by SI were clearly distinguished. @entity0 doing light work and having a low SI had the lowest @entity1 excretion value, 148 mmol/day, and @entity0 doing heavy work and having a high SI had the highest, 260 mmol/day.

title: Assessment of XXXX intake by a short dietary questionnaire.

answer: @entity1


abstract: OBJECTIVES: To evaluate retrospectively the longevity of endodontically treated @entity2 restored with direct resin composite without cusp coverage, with or without the insertion of fibre posts. The null hypothesis was that direct restorations with fibre posts perform better than those without fibre posts. METHODS: @entity0 recruited for this study were treated in the Department of Cariology and Operative Dentistry, University of Turin, between 2008 and 2011. In total, 247 @entity0 with 376 root treated posterior @entity2 , restored with direct resin composite, were recalled for a control visit. Only second-class cavities were considered. Two groups were defined based on the absence (Group A) or presence (Group B) of fibre post. Failures and complications, such as periodontal failure, endodontic failure, tooth extraction, root @entity1 , post @entity1 , post debonding, replacement of restoration, crown displacement, and @entity1 , were noted. Functional restoration quality was evaluated following the modified USPHS criteria. Data were evaluated statistically with ANOVA. RESULTS: Group A consisted of 128 @entity0 with 178 restorations (88 premolars, 90 molars) with a median follow-up of 34.44 months. Group B consisted of 119 @entity0 with 198 @entity2 (92 premolars, 106 molars) with a median follow-up of 35.37 months. Direct restorations with fibre posts were statistically significantly more functional (95.12% success) than those without fibre posts (80% success) because of less marginal discolouration, better marginal integrity, and higher restoration integrity. CONCLUSIONS: The null hypothesis was accepted because direct post-endodontic restorations with fibre posts performed better than restorations without posts after 3 years of masticatory function. CLINICAL SIGNIFICANCE: An evaluation of the longevity of post endodontic direct restoration would seem to enhance the fiber post insertion within a composite restoration to reduce clinical failures.

title: Longevity of class 2 direct restorations in root-filled XXXX : A retrospective clinical study.

answer: @entity2


abstract: Hemodynamic studies were carried out after cardiac catheterization with a floatation catheter in the pulmonary artery and cannulation of the brachial artery for the calculation of cardiac output by means of the Fick principle. Continuous pressure recordings were carried out at rest and under submaximal treadmill exercise in the supine body position in 5 homogeneous groups of 12 @entity0 , all with disorders due to @entity2 . In a control test, hemodynamic investigations were carried out at rest before medication, under stress and after recovery. Similar tests were performed after intravenous administration of either isotonic saline as placebo, @entity5 (1.1 and 1.6 mg/kg) or @entity4 (0.07 and 0.14 mg/kg). It was shown that there was a marked dose-related reduction in peripheral vascular resistance with a maximum effect occurring at 2-5 min after the intravenous administration of @entity5 (1.1 and 1.6 mg/kg) reaching 23 and 39%, respectively, or @entity4 (0.07 and 0.14 mg/kg) attaining 28 and 39%, respectively, at rest and, to a similar extent, under stress conditions. In @entity0 with sinus rhythm, the mean arterial pressure was reduced. Cardiac outputs and @entity1 volumes were increased at rest as well as under stress. There was no evidence of a depressant action of the drug on hemodynamic variables. An interplay of simultaneous changes in preload and afterload seems to be responsible for the effects obtained. The doses used were those commonly employed in the termination of supraventricular @entity3 . However, a potential depressant effect of @entity5 in @entity0 with markedly reduced ventricular function is not excluded by this study.

title: Hemodynamic effects of calcium antagonists in cardiac XXXX .

answer: @entity0


abstract: BACKGROUND: There has been a well-documented increase in the non-medical use of pharmaceutical opioids (PO) worldwide. However, there has been little detailed examination of treatment demand, or the characteristics of those presenting for treatment, particularly for treatments other than opioid substitution. METHODS: Data from closed drug and @entity0 treatment episodes from the @entity0 and Other Drug Treatment Services National Minimum Data Set (AODTS-NMDS, representing non-opioid substitution treatment) in Australia for 2002-2003 to 2010-2011 were examined. In the four jurisdictions where detailed data were available, episodes where @entity4 was the principal drug of concern were compared to episodes for the four most frequently reported pharmaceutical opioids ( @entity1 , @entity5 , @entity3 and @entity2 ). RESULTS: In 2002-2003, most (93%) opioid treatment was related to @entity4 with seven percent of all opioid treatment episodes reporting a PO as the principal drug of concern. In 2010-2011, 20% of all opioid treatment episodes were attributed to POs. Distinct changes over time were observed for different opioids. There was an increase in the average age at the start of treatment for @entity4 and @entity2 episodes, and a reduction in the proportion of females for codeine episodes, with 67% in 2002-2003 compared with 44% in 2010-2011. @entity5 and @entity2 episodes had the lowest current or past injection rates. CONCLUSIONS: Clear differences were observed over time and between different opioids. Monitoring these emerging patterns will be important to inform treatment needs, particularly in light of different patterns of poly drug use, different routes of administration and changing demographic characteristics.

title: Changes in non-opioid substitution treatment episodes for pharmaceutical opioids and XXXX from 2002 to 2011.

answer: @entity4


abstract: BACKGROUND: @entity1 has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing @entity1 burden. Recently, some natural products have been identified for their chemopreventive activity to reduce the @entity1 incidence. @entity10 is known for its potential to treat various ailments in @entity0 beings. The present study was designed to explore the anticancer and antioxidative potential of @entity10 against chemical-induced @entity3 in mammals. METHODS: @entity7 were induced in Swiss albino @entity2 by a single topical application of @entity9 (100   g/100   L @entity6 ) and, 2  wks later, promoted by repeated applications of croton oil (thrice in a wk in 1% @entity6 ) till the end of the experiment (i.e., 16  wk). Hydroalcoholic @entity10 root extract at a dose of 25  mg/kg body weight/d was orally administered at the peri-initiation, postinitiation, and peri-post-initiation stages. RESULTS: @entity10 root extract treatment caused a significant reduction in @entity1 incidence, cumulative number of @entity1 , @entity1 yield, and @entity1 burden, as compared to the @entity9 -croton oil-treated control group. Further, biochemical assays revealed a significant enhancement in the levels of @entity8 , @entity4 dismutase, catalase, @entity5 , and total proteins but a significant reduction in lipid peroxidation levels in both the liver and skin with @entity10 root extract treatment, as compared to carcinogen-treated control group. CONCLUSION: These results suggest that @entity10 has the potential to become a pivotal chemopreventive agent that can reduce @entity1 in mammals.

title: Chemoprevention of chemical-induced @entity7 by XXXX root extract.

answer: @entity10


abstract: BACKGROUND: @entity1 has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing @entity1 burden. Recently, some natural products have been identified for their chemopreventive activity to reduce the @entity1 incidence. @entity10 is known for its potential to treat various ailments in @entity0 beings. The present study was designed to explore the anticancer and antioxidative potential of @entity10 against chemical-induced @entity3 in mammals. METHODS: @entity7 were induced in Swiss albino @entity2 by a single topical application of @entity9 (100   g/100   L @entity6 ) and, 2  wks later, promoted by repeated applications of croton oil (thrice in a wk in 1% @entity6 ) till the end of the experiment (i.e., 16  wk). Hydroalcoholic @entity10 root extract at a dose of 25  mg/kg body weight/d was orally administered at the peri-initiation, postinitiation, and peri-post-initiation stages. RESULTS: @entity10 root extract treatment caused a significant reduction in @entity1 incidence, cumulative number of @entity1 , @entity1 yield, and @entity1 burden, as compared to the @entity9 -croton oil-treated control group. Further, biochemical assays revealed a significant enhancement in the levels of @entity8 , @entity4 dismutase, catalase, @entity5 , and total proteins but a significant reduction in lipid peroxidation levels in both the liver and skin with @entity10 root extract treatment, as compared to carcinogen-treated control group. CONCLUSION: These results suggest that @entity10 has the potential to become a pivotal chemopreventive agent that can reduce @entity1 in mammals.

title: Chemoprevention of chemical-induced XXXX by @entity10 root extract.

answer: @entity7


abstract: AIM OF THE STUDY: Metastases from @entity4 represent between 0.25% and 3.00% of all resected @entity2 . The aim of this study was to review 13 @entity0 with @entity4 metastatic to the pancreas. MATERIAL AND METHODS: Clinical data, time from initial presentation, operative outcome, long-term survival, @entity2 size, presence of lymphatic invasion, and surgical margin status were evaluated. RESULTS: The median age of the @entity0 was 62 years (mean 60.9). The median time for appearance of @entity1 following resection of the primary @entity2 was 9 years (mean 8.38). Pancreatic @entity1 were located in the head of the pancreas in four @entity0 , in the body in three, in the tail in two @entity0 , and four @entity0 had multiple pancreatic localisations. Four (30.7%) pancreatoduodenectomies, 5 (38.5%) distal resections, 2 (15.3%) total pancreatectomies, 1 (7.6%) enucleation, and 1 (7.6%) Roux duodenojejunostomy were performed. Two @entity0 (15.3%) had @entity3 . Operative mortality was 0%. Surgical margins were microscopically positive in 1 (8.3%) @entity0 , and lymph nodes were positive in 2 (16.6%) @entity0 . In our group of 7 deceased @entity0 the mean survival was 19 months (median 16 months). CONCLUSIONS: @entity4 metastatic to the pancreas can occur several years after nephrectomy. In our series a large number of @entity0 with occurrence of symptoms, @entity2 , @entity1 to lymph node, and positive margin were connected with short survival period. Early detection of primary @entity2 , long and thorough @entity0 care, and radical resections give @entity0 a chance for a prolonged life.

title: Results of surgical management of XXXX metastatic to the pancreas.

answer: @entity4


abstract: UNASSIGNED: The purpose of this study was to retrospectively investigate the causes of failure in the first operation and the revision procedure for @entity0 with @entity3 due to @entity4 . Nineteen @entity0 who underwent the revision operations because of failure in the first operation were included in this study. All the @entity1 were identified as fully segmented @entity4 , including 16 cases in thoracolumbar vertebra (T10: 3 @entity0 ; T12: 7 @entity0 ; L1: 6 @entity0 ), and 3 cases in thoracic vertebra (T8). The causes of failure in the first operation and the outcome of revision procedure for @entity0 were retrospectively analyzed. All @entity0 were successfully performed the personalized revision surgeries. The failure reasons of the first operation included limitations of the first operation procedure, no or incomplete resection of the malformed @entity4 , improper operation during surgery, improper internal fixation material, and improper internal fixation scope. The average postoperative scoliosis Cobb's angle and @entity2 Cobb's angle were corrected from 54.1   preoperatively to 23.1   postoperatively, and 59.3   preoperatively to 25.8   postoperatively, respectively. The average postoperative distance between the C7 plumb line and the center sacral vertical line was decreased from 2.5 cm preoperatively to 1.5 cm postoperatively. The average follow-up period was 2.2 years. No serious complication was observed. The cause of the failure of the first operations for the @entity3 due to @entity4 is verified. Our study may provide a basis for the treatment of @entity3 due to @entity4 .

title: The causes of the failure and the revision methods for @entity3 due to XXXX .

answer: @entity4


abstract: UNASSIGNED: The purpose of this study was to retrospectively investigate the causes of failure in the first operation and the revision procedure for @entity0 with @entity3 due to @entity4 . Nineteen @entity0 who underwent the revision operations because of failure in the first operation were included in this study. All the @entity1 were identified as fully segmented @entity4 , including 16 cases in thoracolumbar vertebra (T10: 3 @entity0 ; T12: 7 @entity0 ; L1: 6 @entity0 ), and 3 cases in thoracic vertebra (T8). The causes of failure in the first operation and the outcome of revision procedure for @entity0 were retrospectively analyzed. All @entity0 were successfully performed the personalized revision surgeries. The failure reasons of the first operation included limitations of the first operation procedure, no or incomplete resection of the malformed @entity4 , improper operation during surgery, improper internal fixation material, and improper internal fixation scope. The average postoperative scoliosis Cobb's angle and @entity2 Cobb's angle were corrected from 54.1   preoperatively to 23.1   postoperatively, and 59.3   preoperatively to 25.8   postoperatively, respectively. The average postoperative distance between the C7 plumb line and the center sacral vertical line was decreased from 2.5 cm preoperatively to 1.5 cm postoperatively. The average follow-up period was 2.2 years. No serious complication was observed. The cause of the failure of the first operations for the @entity3 due to @entity4 is verified. Our study may provide a basis for the treatment of @entity3 due to @entity4 .

title: The causes of the failure and the revision methods for XXXX due to @entity4 .

answer: @entity3


abstract: Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of @entity5 ( @entity5 ). However, the potential pharmacological mechanism remains unclear. This study explored the potential effective components and the pharmacokinetic characteristics of DCQD in target tissue in experimental @entity5 in @entity1 . Methods. Acute @entity6 -like symptoms were first induced in @entity1 and then they were given different doses of DCQD (6   g/kg, 12   g/kg, and 24   g/kg body weight) orally. Tissue drug concentration, tissue pathological score, and inflammatory mediators in pancreas, intestine, and lung tissues of @entity1 were examined after 24 hours, respectively. Results. Major components of DCQD could be found in target tissues and their concentrations increased in conjunction with the intake dose of DCQD. The high-dose compounds showed maximal effect on altering levels of anti-inflammatory ( @entity7 and @entity8 ) and proinflammatory markers ( @entity0 @entity2 factor a and @entity3 ) and ameliorating the pathological damage in target tissues (P < 0.05). Conclusions. DCQD could alleviate pancreatic, intestinal, and @entity4 by altering levels of inflammatory cytokines in @entity5 @entity1 with tissue distribution of its components.

title: Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute XXXX in @entity1 .

answer: @entity6


abstract: Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of @entity5 ( @entity5 ). However, the potential pharmacological mechanism remains unclear. This study explored the potential effective components and the pharmacokinetic characteristics of DCQD in target tissue in experimental @entity5 in @entity1 . Methods. Acute @entity6 -like symptoms were first induced in @entity1 and then they were given different doses of DCQD (6   g/kg, 12   g/kg, and 24   g/kg body weight) orally. Tissue drug concentration, tissue pathological score, and inflammatory mediators in pancreas, intestine, and lung tissues of @entity1 were examined after 24 hours, respectively. Results. Major components of DCQD could be found in target tissues and their concentrations increased in conjunction with the intake dose of DCQD. The high-dose compounds showed maximal effect on altering levels of anti-inflammatory ( @entity7 and @entity8 ) and proinflammatory markers ( @entity0 @entity2 factor a and @entity3 ) and ameliorating the pathological damage in target tissues (P < 0.05). Conclusions. DCQD could alleviate pancreatic, intestinal, and @entity4 by altering levels of inflammatory cytokines in @entity5 @entity1 with tissue distribution of its components.

title: Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute @entity6 in XXXX .

answer: @entity1


abstract: Background. @entity1 is a rare complication of @entity3 with few reported cases in the literature. In this case report, we present a 59-year-old male with @entity5 induced @entity4 who developed @entity1 . Case Presentation. A 59-year-old male presented to the emergency department with sharp epigastric @entity2 that radiated to the back and chest. On physical examination, he had abdominal tenderness and distention with hypoactive bowel sounds. Computed tomography (CT) scan of the abdomen showed @entity3 . The @entity0 's condition deteriorated and he was admitted to the intensive care unit (ICU). After he improved and was transferred out of the ICU, the @entity0 developed swelling of the scrotum and penis. Ultrasound (US) of the scrotum showed large hydrocele bilaterally with no varicoceles or testicular masses. Good blood flow was observed for both testicles. The swelling diminished over the next eight days with the addition of Lasix and the @entity0 was discharged home in stable condition. Conclusion. @entity1 is a rare complication of @entity3 . It usually resolves spontaneously with conservative medical management such as diuretics and elevation of the legs.

title: @entity1 as a Complication of @entity5 Induced Acute XXXX .

answer: @entity4


abstract: Background. @entity1 is a rare complication of @entity3 with few reported cases in the literature. In this case report, we present a 59-year-old male with @entity5 induced @entity4 who developed @entity1 . Case Presentation. A 59-year-old male presented to the emergency department with sharp epigastric @entity2 that radiated to the back and chest. On physical examination, he had abdominal tenderness and distention with hypoactive bowel sounds. Computed tomography (CT) scan of the abdomen showed @entity3 . The @entity0 's condition deteriorated and he was admitted to the intensive care unit (ICU). After he improved and was transferred out of the ICU, the @entity0 developed swelling of the scrotum and penis. Ultrasound (US) of the scrotum showed large hydrocele bilaterally with no varicoceles or testicular masses. Good blood flow was observed for both testicles. The swelling diminished over the next eight days with the addition of Lasix and the @entity0 was discharged home in stable condition. Conclusion. @entity1 is a rare complication of @entity3 . It usually resolves spontaneously with conservative medical management such as diuretics and elevation of the legs.

title: @entity1 as a Complication of XXXX Induced Acute @entity4 .

answer: @entity5


abstract: Background. @entity1 is a rare complication of @entity3 with few reported cases in the literature. In this case report, we present a 59-year-old male with @entity5 induced @entity4 who developed @entity1 . Case Presentation. A 59-year-old male presented to the emergency department with sharp epigastric @entity2 that radiated to the back and chest. On physical examination, he had abdominal tenderness and distention with hypoactive bowel sounds. Computed tomography (CT) scan of the abdomen showed @entity3 . The @entity0 's condition deteriorated and he was admitted to the intensive care unit (ICU). After he improved and was transferred out of the ICU, the @entity0 developed swelling of the scrotum and penis. Ultrasound (US) of the scrotum showed large hydrocele bilaterally with no varicoceles or testicular masses. Good blood flow was observed for both testicles. The swelling diminished over the next eight days with the addition of Lasix and the @entity0 was discharged home in stable condition. Conclusion. @entity1 is a rare complication of @entity3 . It usually resolves spontaneously with conservative medical management such as diuretics and elevation of the legs.

title: XXXX as a Complication of @entity5 Induced Acute @entity4 .

answer: @entity1


abstract: OBJECT: @entity3 is one of the most lethal @entity0 @entity1 and appropriate experimental @entity1 models are needed for the development of innovative therapeutic approaches. This paper describes an experimental model of @entity0 @entity3 and a related non invasive imaging technique suitable for monitoring @entity1 growth and metastatization. The aim of the work was the implementation of an experimental platform suitable for assessing the efficacy of new therapeutic agents. MATERIALS AND METHODS: @entity0 @entity3 cells (PANC-1-Luc+) were injected into the pancreas of female athymic @entity4 @entity2 . Magnetic Resonance Imaging (MRI) at 4.7T and Bioluminescence Imaging (BLI) were performed in each @entity2 at three time points after cell inoculation (1, 2 and 3months). Two groups of @entity2 were studied: the first group of n=13 @entity2 in which 5*10(6) cells were injected and the second group of n=10 @entity2 in which 2*10(6) cells were injected. MRI examination included T2w acquisitions and (at the last time point) Dynamic-contrast-enhanced-MRI (DCE-MRI). RESULTS: Each @entity2 underwent three longitudinal MRI and BLI examinations. BLI was more sensitive than MRI producing higher detection rate at early time points. Moreover in one case of abdominal dissemination of @entity3 cells, small tumoral masses were detected by BLI and not detected by MRI. However BLI appears more prone to experimental error most likely due to photon attenuation. In 4 @entity2 BLI produced false negative results. DCE-MRI experiments providing information on @entity1 perfusion were conducted successfully in this anatomical district and demonstrated that the @entity1 tissues from the second experimental group are more vascularized compared to the first group. CONCLUSION: The present study performed on the experimental model of @entity3 here described shows that MRI and BLI are complementary techniques and that synergistic application of both can overcome the intrinsic limitations of each.

title: XXXX growth using magnetic resonance and bioluminescence imaging.

answer: @entity3


abstract: UNASSIGNED: A model of highly metastasizing @entity0 was reproduced and standardized in experiments on BALB/c @entity4 . 4T1 cells characterized by high metastatic activity were transfected with @entity5 ( @entity5 ) gene or firefly luciferase (Luc2) gene. Unmodified 4T1 cells and modified 4T1- @entity5 and 4T1-Luc2 cells were subcutaneously injected to mature female @entity4 into the second mammary fat pads. Quantitative evaluation of the primary node and visceral @entity2 was performed using magnetic-resonance imaging, X-ray and optical tomography. Modification of 4T1 cells with @entity5 gene considerably reduced their invasive and metastatic potential and led to spontaneous regression of the @entity3 in 20% cases. Modification of 4T1 cells with Luc2 gene had practically no effect on proliferative, invasive, and metastatic characteristics of the @entity3 and provided the possibility of quantitative analysis of the @entity3 dynamics by the luminescence intensity. The survival median in @entity4 receiving unmodified 4T1 cells and transfected 4T1- @entity5 and 4  1-Luc2 cells was 32, 42, and 38 days, respectively. Neither primary node nor @entity3 @entity2 accumulated gadolinium-containing contrast agent and Alasens fluorescent tracer. After implantation of 4T1 and 4  1-Luc2 cells, multiple @entity2 were more often detected in the lungs, liver, spleen, spine, and regional lymph nodes and less frequently in the brain, which corresponded to metastasizing profile of @entity1 @entity0 . The developed model of @entity0 4T1 in BALB/c @entity4 with complex detection of multiple organ @entity2 using X-ray microCT, optical, and MRI can be recommended for preclinical studies of new antitumor preparations.

title: Modeling and Integral X-Ray, Optical, and MRI Visualization of Multiorgan Metastases of Orthotopic 4T1 XXXX in BALB/c @entity4 .

answer: @entity0


abstract: UNASSIGNED: A model of highly metastasizing @entity0 was reproduced and standardized in experiments on BALB/c @entity4 . 4T1 cells characterized by high metastatic activity were transfected with @entity5 ( @entity5 ) gene or firefly luciferase (Luc2) gene. Unmodified 4T1 cells and modified 4T1- @entity5 and 4T1-Luc2 cells were subcutaneously injected to mature female @entity4 into the second mammary fat pads. Quantitative evaluation of the primary node and visceral @entity2 was performed using magnetic-resonance imaging, X-ray and optical tomography. Modification of 4T1 cells with @entity5 gene considerably reduced their invasive and metastatic potential and led to spontaneous regression of the @entity3 in 20% cases. Modification of 4T1 cells with Luc2 gene had practically no effect on proliferative, invasive, and metastatic characteristics of the @entity3 and provided the possibility of quantitative analysis of the @entity3 dynamics by the luminescence intensity. The survival median in @entity4 receiving unmodified 4T1 cells and transfected 4T1- @entity5 and 4  1-Luc2 cells was 32, 42, and 38 days, respectively. Neither primary node nor @entity3 @entity2 accumulated gadolinium-containing contrast agent and Alasens fluorescent tracer. After implantation of 4T1 and 4  1-Luc2 cells, multiple @entity2 were more often detected in the lungs, liver, spleen, spine, and regional lymph nodes and less frequently in the brain, which corresponded to metastasizing profile of @entity1 @entity0 . The developed model of @entity0 4T1 in BALB/c @entity4 with complex detection of multiple organ @entity2 using X-ray microCT, optical, and MRI can be recommended for preclinical studies of new antitumor preparations.

title: Modeling and Integral X-Ray, Optical, and MRI Visualization of Multiorgan Metastases of Orthotopic 4T1 @entity0 in BALB/c XXXX .

answer: @entity4


abstract: UNASSIGNED: Moderate wine consumption has been associated with reduced cardiovascular (CV) risk, but most investigations have been conducted in Caucasian populations. To investigate the relationship of wine consumption to CV risk markers, we studied a multi-ethnic sample of middle-aged, healthy @entity0 (N = 2900; 48% white, 28% black, 7% Hispanic, 8% Chinese, 9% Japanese) participating in SWAN over 7 years with repeated assessments of CV risk factors. Consumption of wine was stable and common with 20% reporting none, 69% light (<1/day), 7% moderate ( = 1/day), and 4% heavy (>1/day). To guard against underreporting, we took the maximum reported wine consumption over 7 years as the predictor. We used mixed models with a random intercept and random time to assess the relationship between wine consumption and CV risk factors with moderate consumption as the reference. Outcome variables were log-transformed where necessary. Longitudinal models were adjusted for ethnicity, age, and time-varying menopausal status, hormone therapy use, overall @entity1 consumption, high density lipoprotein (HDL), statin use, and a healthy lifestyle score based on physical activity, not smoking, and weight maintenance. Interactions of wine consumption with time were not significant. Moderate wine consumers had significantly lower levels of @entity2 ( @entity2 , p < .001), @entity3 (p < .001), factor VII (p < .01), and plasminogen activator inhibitor ( @entity4 , p < .05) than @entity0 who drank no or little wine. These associations were independent of significant effects of healthy lifestyle and overall @entity1 consumption and similar across ethnic groups. Moderate wine consumption may protect against CVD via inflammatory and clotting pathways.

title: Moderate wine consumption is associated with lower hemostatic and inflammatory risk factors over 8 years: The study of XXXX 's health across the nation (SWAN).

answer: @entity0


abstract: STUDY DESIGN: Prospective, double-blind, randomized controlled trial. PURPOSE: To determine the ability of hyaluronidase to provide longer lasting @entity1 relief and functional improvement in @entity0 with @entity2 . OVERVIEW OF LITERATURE: Selective nerve root block (SNRB) is a good treatment option in @entity2 . We studied the effectiveness of hyaluronidase when added to the traditional SNRB regimen. METHODS: A sample size of 126 @entity0 per group was necessary. A sample of 252 @entity0 who underwent an injection procedure with or without hyaluronidase due to @entity2 was included in this study. The @entity0 were randomly divided into two groups: the control (C) group and the hyaluronidase (H) group. After SNRB due to @entity2 , the visual analog scale (VAS) was compared at 2, 4, 6, 8, and 12 weeks between the two groups, and the @entity3 index (ODI) was compared at 12 weeks between the two groups. RESULTS: Both groups seemed to have general improvement in VAS, but in C group, the VAS was higher than the H group 2 and 4 weeks after the surgery, and the difference in time-group change between 2 groups was statistically significant (p <0.05). ODI improved in both groups, and the difference in time-group change between 2 groups was not statistically significant (p >0.05). CONCLUSIONS: The rebound @entity1 (the re-occurrence of @entity1 within 2-4 weeks after injection) that occurs within 2-4 weeks after the injection of the routine regimen can be reduced when hyaluronidase is added to the routine SNRB regimen.

title: An evaluation of the effectiveness of hyaluronidase in the selective nerve root block of XXXX : a double blind, controlled clinical trial.

answer: @entity2


abstract: BACKGROUND: @entity5 infections can lead to @entity7 , @entity6 or facilitate co- @entity4 by other pathogens. @entity5 is associated with the exacerbation of chronic conditions like @entity1 and @entity3 and consequently, these result in acute hospitalizations. This study estimated the number, proportions and costs from a payer perspective of hospital admissions related to severe @entity6 . METHODS: We analyzed retrospectively, a database of all acute inpatient stays from a non-random sample of eleven hospitals using the Belgian Minimal Hospital Summary Data. Codes from the International Classification of Diseases, Ninth Revision, Clinical Modification was used to identify and diagnose cases of @entity2 and @entity5 (PI), respiratory and circulatory (RC), and the related complications. RESULTS: During 2002-2007, we estimated relative hospital admission rates of 1.69% (20960/1237517) and 21.79% (269634/1237517) due to primary PI and RC, respectively. The highest numbers of hospital admissions with primary diagnosis as PI were reported for the elderly @entity0 group (n   =   10184) followed by for @entity0 below five years of age (n   =   3451). Of the total primary PI and RC hospital admissions, 56.14% (11768/20960) and 63.48% (171172/269634) of cases had at least one possible @entity5 -related complication with the highest incidence of complications reported for the elderly @entity0 group. Overall mortality rate in @entity0 with PI and RC were 9.25% (1938/20960) and 5.51% (14859/269634), respectively. Average lengths of hospital stay for PI was 11.6        12.3  days whereas for RC it was 9.1        12.7  days. Annual average costs were 20.2 and 274.6 million @entity8 for PI and RC hospitalizations. Average cost per hospitalization for PI and RC were 5779 and 6111 @entity8 (2007), respectively. These costs increased with the presence of complications (PI: 7159, RC: 7549 @entity8 ). CONCLUSION: The clinical and economic burden of primary @entity5 hospitalizations in Belgium is substantial. The elderly @entity0 group together with @entity0 aged <18  years were attributed with the majority of all primary PI and RC hospitalizations. TRIAL REGISTRATION: Not applicable.

title: XXXX and @entity5 , and respiratory and circulatory hospital admissions in Belgium: a retrospective database study.

answer: @entity2


abstract: BACKGROUND: @entity5 infections can lead to @entity7 , @entity6 or facilitate co- @entity4 by other pathogens. @entity5 is associated with the exacerbation of chronic conditions like @entity1 and @entity3 and consequently, these result in acute hospitalizations. This study estimated the number, proportions and costs from a payer perspective of hospital admissions related to severe @entity6 . METHODS: We analyzed retrospectively, a database of all acute inpatient stays from a non-random sample of eleven hospitals using the Belgian Minimal Hospital Summary Data. Codes from the International Classification of Diseases, Ninth Revision, Clinical Modification was used to identify and diagnose cases of @entity2 and @entity5 (PI), respiratory and circulatory (RC), and the related complications. RESULTS: During 2002-2007, we estimated relative hospital admission rates of 1.69% (20960/1237517) and 21.79% (269634/1237517) due to primary PI and RC, respectively. The highest numbers of hospital admissions with primary diagnosis as PI were reported for the elderly @entity0 group (n   =   10184) followed by for @entity0 below five years of age (n   =   3451). Of the total primary PI and RC hospital admissions, 56.14% (11768/20960) and 63.48% (171172/269634) of cases had at least one possible @entity5 -related complication with the highest incidence of complications reported for the elderly @entity0 group. Overall mortality rate in @entity0 with PI and RC were 9.25% (1938/20960) and 5.51% (14859/269634), respectively. Average lengths of hospital stay for PI was 11.6        12.3  days whereas for RC it was 9.1        12.7  days. Annual average costs were 20.2 and 274.6 million @entity8 for PI and RC hospitalizations. Average cost per hospitalization for PI and RC were 5779 and 6111 @entity8 (2007), respectively. These costs increased with the presence of complications (PI: 7159, RC: 7549 @entity8 ). CONCLUSION: The clinical and economic burden of primary @entity5 hospitalizations in Belgium is substantial. The elderly @entity0 group together with @entity0 aged <18  years were attributed with the majority of all primary PI and RC hospitalizations. TRIAL REGISTRATION: Not applicable.

title: @entity2 and XXXX , and respiratory and circulatory hospital admissions in Belgium: a retrospective database study.

answer: @entity5


abstract: BACKGROUND: In @entity0 with severe @entity2 , @entity4 of cardiac performance is common and is often associated with left ventricular (LV) dilatation to maintain @entity1 volume. Although it is essential to optimize cardiac preload to maintain tissue perfusion in @entity0 with severe @entity2 , the optimal preload remains unknown. This study aimed to evaluate the reliability of global end-diastolic volume index (GEDI) as a parameter of cardiac preload in the early phase of severe @entity2 . METHODS: Ninety-three mechanically ventilated @entity0 with @entity5 /acute @entity6 syndrome secondary to @entity2 were enrolled for subgroup analysis in a multicenter, prospective, observational study. @entity0 were divided into two groups-with @entity2 -induced @entity3 ( @entity7 ) and without @entity7 ( @entity7 )-according to a threshold LV ejection fraction (LVEF) of 50% on the day of enrollment. Both groups were further subdivided according to a threshold @entity1 volume variation ( @entity8 ) of 13% as a parameter of fluid responsiveness. RESULTS: On the day of enrollment, there was a positive correlation (r   =   0.421, p   =   0.045) between GEDI and @entity8 in the @entity7 group, whereas this paradoxical correlation was not found in the @entity7 group and both groups on day 2. To evaluate the relationship between attainment of cardiac preload optimization and GEDI value, GEDI with @entity8  <=13% and @entity8 >13% was compared in both the @entity7 and @entity7 groups. @entity8  <=13% implies the attainment of cardiac preload optimization. Among @entity0 with @entity7 , GEDI was higher in @entity0 with @entity8 >13% than in @entity0 with @entity8  <=13% on the day of enrollment (872 [785-996] mL/m(2) vs. 640 [597-696] mL/m(2); p   <   0.001); this finding differed from the generally recognized relationship between GEDI and @entity8 . However, GEDI was not significantly different between @entity0 with @entity8  <=13% and @entity8 >13% in the @entity7 group on the day of enrollment and both groups on day 2. CONCLUSIONS: In the early phase of severe @entity2 in mechanically ventilated @entity0 , there was no constant relationship between GEDI and fluid reserve responsiveness, irrespective of the presence of @entity7 . GEDI should be used as a cardiac preload parameter with awareness of its limitations.

title: Limitations of global end-diastolic volume index as a parameter of cardiac preload in the early phase of severe XXXX : a subgroup analysis of a multicenter, prospective observational study.

answer: @entity2


abstract: OBJECTIVE: To analyse oncological and functional outcomes of salvage radical prostatectomy (SRP) in @entity0 with @entity3 and to compare outcomes of @entity0 within and outside the European Association of Urology (EAU) guideline criteria (organ-confined @entity3  <=T2b, Gleason score  <=7 and preoperative PSA level <10  ng/mL) for SRP. @entity0 AND METHODS: In all, 55 @entity0 who underwent SRP from January 2007 to December 2012 were retrospectively analysed. Kaplan-Meier curves assessed time to biochemical recurrence (BCR), @entity1 ( @entity1 ) and @entity2 -specific survival. Cox regressions addressed factors influencing BCR and @entity1 . BCR was defined as a PSA level of >0.2  ng/mL and rising, continence as the use of 0-1 safety pad/day, and potency as a five-item version of the International Index of Erectile Function score of >= 18. RESULTS: The median follow-up was 36  months. After SRP, 42.0% of the @entity0 experienced BCR, 15.9% developed @entity1 , and 5.5% died from @entity3 . @entity0 fulfilling the EAU guideline criteria were less likely to have positive lymph nodes (LNs) and had significantly better BCR-free survival (5-year BCR-free survival 73.9% vs 11.6%; P = 0.001). In multivariate analysis, low-dose-rate brachytherapy as primary treatment (P = 0.03) and presence of positive LNs at SRP (P  = 0.02) were significantly associated with worse BCR-free survival. The presence of positive LNs or Gleason score >7 at SRP were independently associated with @entity1 . The urinary continence rate at 1  year after SRP was 74%. Seven @entity0 (12.7%) had complications >= III (Clavien grade). CONCLUSION: SRP is a safe procedure providing @entity2 control and reasonable urinary continence. Oncological outcomes are significantly better in @entity0 who met the EAU guideline recommendations.

title: Salvage radical prostatectomy for XXXX : verification of European Association of Urology guideline criteria.

answer: @entity3


abstract: Eight @entity0 (7 females and one male) ranging in age from 6 to 30 years (mean 11.2 years), with secundum-type @entity1 (o.s. @entity6 ) and @entity5 (CVM) were surgically corrected at the Cardiac Surgery Department of Massa Hospital (Massa-Italy) from 1974 to 1981. All @entity0 were studied with non invasive diagnostic techniques and with cardiac catheterization and angiography. All had @entity2 of variable degree. On the ECG, there were P and QRS wave abnormalities but no superior quadrant QRS axis deviation suggestive of @entity7 . At operation the cleft(s) was found in variable positions: on the anterior leaflet in 4 cases and on the posterior leaflet in four. In two cases there was a double cleft. Correction was accomplished in 5 cases with direct repair of CVM, associated with various types of anuloplasty and in 2 cases anuloplasty only was done, without suturing the cleft. The @entity4 was closed by direct suture in one case and with a Dacron patch in the remaining seven. There was one early death in the first 24 hour post-operatively. The seven surviving @entity0 have been followed for a period of time ranging between 2 and 93 months (mean 29 months). No survivor has been re-evaluated by cardiac catheterization and cineangiography. No @entity0 shows clinical or non-invasive evidence of residual @entity2 behind grade I (slight). We conclude that: 1) the CVM associated with o.s. @entity6 cannot be securely diagnosed preoperatively with the common diagnostic techniques, even when producing severe @entity2 , except perhaps by B-mode echocardiography; 2) the CVM (part of the spectrum of endocardial @entity3 ) in no cases was associated with the typical ECG or angiocardiographic abnormalities; 3) the CVM associated with o.s. @entity6 should always be repaired because, compared to the CVM that occurs with @entity7 , its site and regurgitation characteristics are variable, and simple @entity6 closure may not be sufficient.

title: [Ostium secundum type of @entity4 associated with XXXX ].

answer: @entity5


abstract: Eight @entity0 (7 females and one male) ranging in age from 6 to 30 years (mean 11.2 years), with secundum-type @entity1 (o.s. @entity6 ) and @entity5 (CVM) were surgically corrected at the Cardiac Surgery Department of Massa Hospital (Massa-Italy) from 1974 to 1981. All @entity0 were studied with non invasive diagnostic techniques and with cardiac catheterization and angiography. All had @entity2 of variable degree. On the ECG, there were P and QRS wave abnormalities but no superior quadrant QRS axis deviation suggestive of @entity7 . At operation the cleft(s) was found in variable positions: on the anterior leaflet in 4 cases and on the posterior leaflet in four. In two cases there was a double cleft. Correction was accomplished in 5 cases with direct repair of CVM, associated with various types of anuloplasty and in 2 cases anuloplasty only was done, without suturing the cleft. The @entity4 was closed by direct suture in one case and with a Dacron patch in the remaining seven. There was one early death in the first 24 hour post-operatively. The seven surviving @entity0 have been followed for a period of time ranging between 2 and 93 months (mean 29 months). No survivor has been re-evaluated by cardiac catheterization and cineangiography. No @entity0 shows clinical or non-invasive evidence of residual @entity2 behind grade I (slight). We conclude that: 1) the CVM associated with o.s. @entity6 cannot be securely diagnosed preoperatively with the common diagnostic techniques, even when producing severe @entity2 , except perhaps by B-mode echocardiography; 2) the CVM (part of the spectrum of endocardial @entity3 ) in no cases was associated with the typical ECG or angiocardiographic abnormalities; 3) the CVM associated with o.s. @entity6 should always be repaired because, compared to the CVM that occurs with @entity7 , its site and regurgitation characteristics are variable, and simple @entity6 closure may not be sufficient.

title: [Ostium secundum type of XXXX associated with @entity5 ].

answer: @entity4


abstract: UNASSIGNED: Objectives. Verbal memory (VM) impairment is a trait feature of @entity2 ( @entity2 ) that is present at illness onset and associated with functional outcome. However, little is known about the morphological abnormalities underlying this deficit early in the disease course. This study examined the neurobiological correlates of @entity1 in euthymic newly diagnosed @entity0 , with attention to frontal and medial temporal (MT) structures known to contribute to VM. Methods. Euthymic @entity0 with @entity2 recently recovered from their first episode of @entity2 (n = 42) were compared with healthy subjects (n = 37) using measures of the California Verbal Learning Test (CVLT-II) associated with frontal and MT functioning. A subset of @entity0 had 3T MRI scan (n = 31 @entity0 group, n = 30 healthy subject group). Hippocampal and prefrontal volumes were analyzed using FreeSurfer 5.1 and correlated with their corresponding CVLT-II subscores. Results. @entity0 showed decreased performance in total learning as well as short and long delay verbal recall. Consistent with @entity3 , they also showed @entity4 and @entity5 . In the @entity0 group only, left hippocampal volumes were negatively correlated with these measures. Conclusions. These results suggest that anomalous MT functioning is involved with @entity1 early in the course of @entity2 .

title: Verbal memory impairment in new onset XXXX : Relationship with frontal and medial temporal morphology.

answer: @entity2


abstract: BACKGROUND: The optimal technique for removal of diminutive or small @entity1 is debatable. OBJECTIVE: To compare the complete resection rates of cold snare polypectomy (CSP) and @entity3 ( @entity3 ) for the removal of @entity2   <=7  mm. DESIGN: Prospective randomized controlled study. SETTING: A university hospital. @entity0 : A total of 139 @entity0 who were found to have  >= 1 @entity2   <=7  mm. INTERVENTIONS: @entity1 were randomized to be treated with either CSP or @entity3 . After the initial polypectomy, additional EMR was performed at the polypectomy site to assess the presence of residual polyp tissue. MAIN OUTCOME MEASUREMENTS: Absence of residual polyp tissue in the EMR specimen of the polypectomy site was defined as complete resection. RESULTS: Among a total of 145 @entity1 , 128 (88.3%) were @entity2 . The overall complete resection rate  for @entity2 was significantly higher in the CSP group compared with the @entity3 group (57/59, 96.6% vs 57/69, 82.6%; P  = .011). Although the complete resection rates for @entity2   <=4  mm were not different (27/27, 100% vs 31/32, 96.9%; P  = 1.000), the complete resection rates for @entity2 sized 5 to 7  mm was significantly higher in the CSP group compared with the @entity3 group (30/32, 93.8% vs 26/37, 70.3%; P  = .013). LIMITATIONS: Single-center study. CONCLUSION: CSP is recommended for the complete resection of @entity2   <=7  mm. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT01665898.).

title: Cold snare polypectomy versus XXXX for diminutive and small @entity1 : a randomized controlled trial.

answer: @entity3


abstract: BACKGROUND: The optimal technique for removal of diminutive or small @entity1 is debatable. OBJECTIVE: To compare the complete resection rates of cold snare polypectomy (CSP) and @entity3 ( @entity3 ) for the removal of @entity2   <=7  mm. DESIGN: Prospective randomized controlled study. SETTING: A university hospital. @entity0 : A total of 139 @entity0 who were found to have  >= 1 @entity2   <=7  mm. INTERVENTIONS: @entity1 were randomized to be treated with either CSP or @entity3 . After the initial polypectomy, additional EMR was performed at the polypectomy site to assess the presence of residual polyp tissue. MAIN OUTCOME MEASUREMENTS: Absence of residual polyp tissue in the EMR specimen of the polypectomy site was defined as complete resection. RESULTS: Among a total of 145 @entity1 , 128 (88.3%) were @entity2 . The overall complete resection rate  for @entity2 was significantly higher in the CSP group compared with the @entity3 group (57/59, 96.6% vs 57/69, 82.6%; P  = .011). Although the complete resection rates for @entity2   <=4  mm were not different (27/27, 100% vs 31/32, 96.9%; P  = 1.000), the complete resection rates for @entity2 sized 5 to 7  mm was significantly higher in the CSP group compared with the @entity3 group (30/32, 93.8% vs 26/37, 70.3%; P  = .013). LIMITATIONS: Single-center study. CONCLUSION: CSP is recommended for the complete resection of @entity2   <=7  mm. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT01665898.).

title: Cold snare polypectomy versus @entity3 for diminutive and small XXXX : a randomized controlled trial.

answer: @entity1


abstract: UNASSIGNED: Liver function test (LFT) abnormalities are often observed in @entity0 with @entity4 ( @entity4 ). However, the relation of LFTs with outcomes has not been well described. @entity0 of the VA Palo Alto Health Care System (3 inpatient facilities and 7 community clinics) with a complete set of LFTs in the 60  days before a first @entity4 diagnosis were included in the analysis from January 2005 to April 2013. A total of 2,096 @entity0 met inclusion criteria. @entity0 were a mean of 71    12  years old, 97% were @entity0 , 57% had a previous diagnosis of @entity5 , and the mean left ventricular ejection fraction was 51    12%. The median (twenty fifth and seventy fifth) values were albumin 3.6 g/dl (3.3, 3.9), @entity2 transaminase 21 IU/L (16, 30), @entity1 transaminase 24 IU/L (20,31), AP 70 IU/L (57, 87), and total @entity3 0.8 mg/dl (0.6, 1.0). There were 851 deaths (41%) over a mean duration of 41    27  months. Mortality significantly increased with lower values of albumin and @entity2 transaminase and higher levels of @entity1 transaminase and AP. The association with total @entity3 was not significant. In conclusion, many LFT values in the "normal" range are independently associated with decreased survival beyond traditional risk factors for mortality in @entity4 .

title: Effect of Minor Liver Function Test Abnormalities and Values Within the Normal Range on Survival in XXXX .

answer: @entity4


abstract: OBJECTIVE: Embryonic germ (EG) cells are the results of reprogramming primordial germ cells (PGC) in vitro. Studying these cells can be of benefit in determining the mechanism by which specialized cells acquire pluripotency. Therefore in the current study we have tried to derive @entity0 EG cells with inhibition of @entity2 ( @entity2 ) and mitogen-activated protein kinase kinase (MEK) signaling pathways. MATERIALS AND METHODS: In this experimental study, @entity0 PGCs were cultured under feeder free condition with two small molecules that inhibited the above mentioned pathways. Under this condition only two-day presence of @entity4 ( @entity4 ) as a survival factor was applied for PGC reprogramming. Pluripotency of the resultant EG cells were further confirmed by immunofluorescent staining, directed differentiation ability to neural and cardiac cells, and their contribution to @entity1 formation as well. Moreover, chromosomal stability of two different EG cells were assessed through G-banding technique. RESULTS: Formerly, derivation of @entity0 EG cells were observed solely in the presence of glycogen synthase kinase-3 ( @entity5 ) and MEK pathway inhibitors. Due to some drawbacks of inhibiting @entity5 molecules such as @entity3 , in the present study we have attempted to assess a feeder-free protocol that derives EG cells by the simultaneous suppression of @entity2 signaling and the MEK pathway. We have shown that @entity0 EG cells could be generated in the presence of two inhibitors that suppressed the above mentioned pathways. Of note, inhibition of @entity2 instead of @entity5 significantly maintained chromosomal integrity. The resultant EG cells demonstrated the hallmarks of pluripotency in protein expression level and also showed in vivo and in vitro differentiation capacities. CONCLUSION: @entity0 EG cells with higher karyotype stability establish from PGCs by inhibiting @entity2 and MEK signaling pathways.

title: Generation of XXXX Embryonic Germ Cells via Inhibition of TGF   and MEK Pathways.

answer: @entity0


abstract: UNASSIGNED: The spatial attention mechanisms of orienting and zooming cooperate to properly select visual information from the environment and plan eye movements accordingly. Despite the fact that orienting ability has been extensively studied in infancy, the zooming mechanism - namely, the ability to distribute the attentional resources to a small or large portion of the visual field - has never been tested before. The aim of the present study was to evaluate the attentional zooming abilities of 8-month-old @entity0 . An eye-tracker device was employed to measure the @entity5 ( @entity5 ) at the onset of a @entity1 at two eccentricities. The size of the more eccentric target was adjusted in order to counteract the effect of cortical magnification. Before the target display, attentional resources were automatically focused (zoom-in) or spread out (zoom-out) by using a small or large cue, respectively. Two different cue-target intervals were also employed to measure the time course of this attentional mechanism. The results showed that @entity0 ' @entity5 varied as a function of the cue size. Moreover, a clear time course emerged, demonstrating that @entity0 can rapidly adjust the attentional focus size during a pre-saccadic temporal window. These findings could serve as an early marker for @entity2 associated with attentional zooming dysfunction such as @entity3 and @entity4 .

title: The attentional 'zoom-lens' in 8-month-old XXXX .

answer: @entity0


abstract: Alemtuzumab is a humanized monoclonal antibody against @entity3 ( @entity3 ) and is approved for the therapy of relapsing-remitting @entity1 . The application of alemtuzumab leads to a rapid, but long-lasting depletion predominantly of @entity3 -bearing B and T cells with reprogramming effects on immune cell composition resulting in the restoration of tolerogenic networks. Alemtuzumab has proven high efficacy in clinical phase II and III trials, where interferon b-1a was used as active comparator. However, alemtuzumab is associated with frequent and considerable risks. Most importantly secondary @entity2 affects 30%-40% of @entity0 , predominantly impairing thyroid function. Extensive monitoring and early intervention allow for an appropriate risk management. However, new and reliable biomarkers for individual risk stratification and treatment response to improve @entity0 selection and therapy guidance are a significant unmet need. Only a deeper understanding of the underlying mechanisms of action (MOA) will reveal such markers, maximizing the best potential risk-benefit ratio for the individual @entity0 . This review provides and analyses the current knowledge on the MOA of alemtuzumab. Most recent data on efficacy and safety of alemtuzumab are presented and future research opportunities are discussed.

title: Alemtuzumab in XXXX : Mechanism of Action and Beyond.

answer: @entity1


abstract: A missing or @entity2 plate is often an important limiting factor for immediate implant placement. @entity3 dental implants enhanced with porous @entity5 -based trabecular metal material (PTTM) are designed for osseoincorporation, a combination of vascularized bone ingrowth and osseointegration (bone on-growth). @entity1 ( @entity1 ) contains growth factors with good handling characteristics. However, the combination of these 2 materials in @entity2 regeneration associated with immediate implant therapy has not been reported. A 65-year-old Asian @entity0 presented with a failing central incisor. Most of the @entity2 plate of the socket was missing. A PTTM enhanced implant was immediately placed with @entity1 . Cone beam computed tomography scans 12 months after the insertion of the definitive restoration showed regeneration of @entity2 . A combination of a PTTM enhanced implant, @entity1 , and a custom healing abutment may have an advantage in retaining biologically active molecules and form a scaffold for @entity4 and osteogenesis. This treatment protocol may be a viable option for immediate implant therapy in a failed tooth with @entity2 .

title: Immediate placement of a porous-tantalum, trabecular metal-enhanced XXXX dental implant with demineralized bone matrix into a socket with @entity1 : a clinical report.

answer: @entity3


abstract: A missing or @entity2 plate is often an important limiting factor for immediate implant placement. @entity3 dental implants enhanced with porous @entity5 -based trabecular metal material (PTTM) are designed for osseoincorporation, a combination of vascularized bone ingrowth and osseointegration (bone on-growth). @entity1 ( @entity1 ) contains growth factors with good handling characteristics. However, the combination of these 2 materials in @entity2 regeneration associated with immediate implant therapy has not been reported. A 65-year-old Asian @entity0 presented with a failing central incisor. Most of the @entity2 plate of the socket was missing. A PTTM enhanced implant was immediately placed with @entity1 . Cone beam computed tomography scans 12 months after the insertion of the definitive restoration showed regeneration of @entity2 . A combination of a PTTM enhanced implant, @entity1 , and a custom healing abutment may have an advantage in retaining biologically active molecules and form a scaffold for @entity4 and osteogenesis. This treatment protocol may be a viable option for immediate implant therapy in a failed tooth with @entity2 .

title: Immediate placement of a porous-tantalum, trabecular metal-enhanced @entity3 dental implant with demineralized bone matrix into a socket with XXXX : a clinical report.

answer: @entity1


abstract: This work is focused on the development of an analytical procedure for the improvement of the Organic Matter structure characterization, particularly the @entity0 . Two fractions of algal organic matter from laboratory cultures of algae ( @entity2 ) and cyanobacteria ( @entity3 ) were extracted with XAD resins. The fractions were studied using laser desorption ionization (LDI) and Matrix-Assisted laser desorption ionization time-of-flight mass spectrometry (MALDI- @entity1 ). A comparison with the natural organic matter characteristics from commercial humic acids and fulvic acids extracted from Suwannee River was performed. Results show that algal and natural organic matters have unique quasi-polymeric structures. Significant repeating patterns were identified. Different fractions extracted from organic matter with common origin had common structures. Thus, 44, 114 and 169Da peaks separation for fractions from @entity2 organic matter and 28, 58 and 100Da for @entity3 ones were clearly observed. Using the developed protocol, a structural scheme and organic matter composition were obtained. The range 600-2000Da contained more architectural composition differences than the range 100-600Da, suggesting that organic matter is composed of an assembly of common small molecules. Associated to specific monomers, particular patterns were common to all samples but assembly and resulting structure were unique for each organic matter. Thus, XAD fractionation coupled to mass spectroscopy allowed determining a specific fingerprint for each organic matter.

title: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI- XXXX -MS) coupled to XAD fractionation: Method to algal organic matter characterization.

answer: @entity1


abstract: INTRODUCTION: Flexor digitorum longus transfer and medial displacement calcaneal osteotomy have shown favourable results in the treatment of adult acquired flat @entity3 stage 2. Little is known about the resorbable interference screw for tendon fixation and postoperative @entity0 satisfaction though. Moreover possible changes of radiographic parameters at final follow-up, possible implant-associated complications and differences concerning clinical results at final follow-up to other studies using bone tunnel techniques for fixation of the FDL tendon were investigated. MATERIALS AND METHODS: 21 feet in 21 @entity0 with a mean age of 51  years were evaluated pre- and postoperatively after a standardised operative procedure using MDCO and FDL transfer with interference screw fixation. @entity0 were evaluated with the American Orthopaedic Foot and Ankle Society Hindfoot Score and the Visual Analogue Scale at an average follow-up of 20  months. Hindfoot radiographic parameters were evaluated according to AOFAS guidelines. For statistical analysis SPSS v.15.0.1 was used. RESULTS: The average AOFAS Score (from 42 to 95 points) and VAS (from 0.5 to 8 points) both increased significantly (p  <  0.001 each) from preoperative to final follow-up as well as the hindfoot valgus (from 10 to 4 degrees (p  =  0.005)) and the lateral talo-first metatarsal angle (from 13.6 preoperative to 5.2   at follow-up). 88 percent of @entity0 evaluated the postoperative result with "very good" or "good". Implant-associated complications could not be detected. CONCLUSION: We conclude that interference screw fixation for FDL transfer is a safe and promising operative technique, allowing a smaller skin incision without disrupting the normal interconnections at the knot of Henry, while achieving very high @entity0 satisfaction and improving postoperative function as well as relieving @entity2 . This method is technically easy to perform, has a low complication risk and we, therefore, recommend this fixation technique in @entity0 with adult acquired @entity1 stage 2.

title: Interference screw for fixation of FDL transfer in the treatment of adult acquired flat XXXX stage II.

answer: @entity3


abstract: @entity2 with oncogenic types of @entity4 ) is the most important risk factor associated with @entity1 . This study detected the oncogenic HPV genotypes in cervical @entity1 in relation to clinicopathological findings using a cross-sectional descriptive method in 2011 and 2012. Cervical swabs and colposcopy-directed cervical biopsy tissues were collected from 108 @entity0 (median age 45 years;range 20-78) showing cervical cytological changes at Sanpya General Hospital, Yangon, Myanmar. HPV DNA testing and genotyping were performed by polymerase chain reaction and restriction fragment length polymorphism. HPV was identified in @entity0 with @entity6 ( @entity6 ) 1 (44.4%), CIN2 (63.2%), CIN3 (70.6%), and @entity3 ( @entity3 ) (74.1%). The association between cervical @entity1 and HPV positivity was highly significant (p   0.008). Most @entity0 infected with HPV were between 40-49 years of age, and the youngest were in the 20- to 29-year-old age group. The most common genotype was @entity5 (65.6%) with the following distribution:70% in CIN1, 41.7% in CIN2, 91.7% in CIN3, and 60% in @entity3 . HPV-31 was the second-most frequent (21.9%):30% in CIN1, 33.3% in CIN2, 8.3% in CIN3, and 15% in @entity3 . The third-most frequent-genotype was HPV-18 (7.8%):8.3% in CIN1, and 20% in @entity3 . Another genotype was HPV-58 (4.7%):16.7% in CIN1 and 5% in @entity3 . The majority of @entity6 / @entity3 cases were associated with HPV genotypes 16, 31, 18, and 58. If oncogenic HPV genotypes are positive, the possibility of cervical @entity1 can be predicted. Knowledge of the HPV genotypes distribution can predict the effectiveness of the currently used HPV vaccine.

title: Trend of XXXX genotypes in cervical @entity1 observed in a newly developing township in yangon, myanmar.

answer: @entity4


abstract: @entity2 with oncogenic types of @entity4 ) is the most important risk factor associated with @entity1 . This study detected the oncogenic HPV genotypes in cervical @entity1 in relation to clinicopathological findings using a cross-sectional descriptive method in 2011 and 2012. Cervical swabs and colposcopy-directed cervical biopsy tissues were collected from 108 @entity0 (median age 45 years;range 20-78) showing cervical cytological changes at Sanpya General Hospital, Yangon, Myanmar. HPV DNA testing and genotyping were performed by polymerase chain reaction and restriction fragment length polymorphism. HPV was identified in @entity0 with @entity6 ( @entity6 ) 1 (44.4%), CIN2 (63.2%), CIN3 (70.6%), and @entity3 ( @entity3 ) (74.1%). The association between cervical @entity1 and HPV positivity was highly significant (p   0.008). Most @entity0 infected with HPV were between 40-49 years of age, and the youngest were in the 20- to 29-year-old age group. The most common genotype was @entity5 (65.6%) with the following distribution:70% in CIN1, 41.7% in CIN2, 91.7% in CIN3, and 60% in @entity3 . HPV-31 was the second-most frequent (21.9%):30% in CIN1, 33.3% in CIN2, 8.3% in CIN3, and 15% in @entity3 . The third-most frequent-genotype was HPV-18 (7.8%):8.3% in CIN1, and 20% in @entity3 . Another genotype was HPV-58 (4.7%):16.7% in CIN1 and 5% in @entity3 . The majority of @entity6 / @entity3 cases were associated with HPV genotypes 16, 31, 18, and 58. If oncogenic HPV genotypes are positive, the possibility of cervical @entity1 can be predicted. Knowledge of the HPV genotypes distribution can predict the effectiveness of the currently used HPV vaccine.

title: Trend of @entity4 genotypes in cervical XXXX observed in a newly developing township in yangon, myanmar.

answer: @entity1


abstract: The development of @entity10 is a common aging change in industrialized nations. While most @entity0 have asymptomatic @entity11 , around one in five develops symptomatic @entity2 . This is characterized by recurrent @entity4 and disturbed bowel habit. Some of the @entity3 episodes are prolonged and are due to @entity5 , which itself may be complicated by abscess, perforation, fistulation, or @entity6 formation. Risk factors favouring the development of symptomatic @entity2 include @entity1 , smoking and diets low in fiber but high in red meat and animal fat. What determines the transition from asymptomatic @entity11 to symptomatic @entity2 is unclear but neuromuscular changes following @entity5 may be responsible in some cases. The severity of symptoms generated depends on @entity3 processing which is influenced by psychosocial factors. These are important considerations in deciding optimal @entity0 management. Prior theories of the cause of @entity11 suggested that @entity8 was an important cause, but new data challenge this and has provoked new ideas. Underlying mechanisms causing @entity11 include weakening of the @entity7 . Dietary induced changes in microbiota and the host inflammatory response may underlie the subsequent development of acute/chronic @entity9 and its sequela.

title: Changing views on XXXX : impact of aging, @entity1 , diet, and microbiota.

answer: @entity2


abstract: The development of @entity10 is a common aging change in industrialized nations. While most @entity0 have asymptomatic @entity11 , around one in five develops symptomatic @entity2 . This is characterized by recurrent @entity4 and disturbed bowel habit. Some of the @entity3 episodes are prolonged and are due to @entity5 , which itself may be complicated by abscess, perforation, fistulation, or @entity6 formation. Risk factors favouring the development of symptomatic @entity2 include @entity1 , smoking and diets low in fiber but high in red meat and animal fat. What determines the transition from asymptomatic @entity11 to symptomatic @entity2 is unclear but neuromuscular changes following @entity5 may be responsible in some cases. The severity of symptoms generated depends on @entity3 processing which is influenced by psychosocial factors. These are important considerations in deciding optimal @entity0 management. Prior theories of the cause of @entity11 suggested that @entity8 was an important cause, but new data challenge this and has provoked new ideas. Underlying mechanisms causing @entity11 include weakening of the @entity7 . Dietary induced changes in microbiota and the host inflammatory response may underlie the subsequent development of acute/chronic @entity9 and its sequela.

title: Changing views on @entity2 : impact of aging, XXXX , diet, and microbiota.

answer: @entity1


abstract: BACKGROUND: Major @entity3 is diagnosed in 18% of @entity0 following @entity4 ( @entity4 ), and the antidepressant @entity5 is shown to effectively decrease @entity3 and improve @entity2 prognosis. We observed the effect of @entity5 on cardiac electrophysiology in vivo in a @entity1 model of @entity4 and the potential mechanism. METHODS AND RESULTS: Eighty adult male @entity1 (200-250 g) were randomly assigned to five groups: normal control (control group), @entity4 ( @entity4 group), @entity3 ( @entity3 group), @entity4 (model group), and @entity4 treated with intragastric administration of 10 mg/kg @entity5 ( @entity5 group). @entity4 was induced by left anterior descending coronary artery ligation. @entity3 was developed by 4-week chronic mild stress (CMS). Behavior measurement was done before and during the experiment. Electrophysiology study in vivo and Western blot analysis were carried on after 4 weeks of CMS. After 4 weeks of CMS, @entity3 -like behaviors were observed in the @entity4 , @entity3 , and model groups, and chronic @entity5 administration could significantly improve those behaviors (P<0.05 vs model group). @entity5 significantly increased the @entity7 threshold compared with the model group (20.20  9.32 V vs 14.67  1.85 V, P<0.05). Expression of @entity9 was significantly reduced by 29%  12%, 24%  6%, and 41%  15%, respectively, in the @entity4 group, CMS group, and model group, which could be improved by @entity5 (30%  9%). But @entity5 showed no improvement on the @entity4 -induced loss of @entity8 . CONCLUSION: The susceptibility to @entity6 was @entity3 and @entity4 @entity1 , and @entity5 may reduce the incidence of @entity6 in @entity4 @entity1 and thus improve the prognosis. This may be related in part to the upregulation of @entity9 by @entity5 .

title: Effect and mechanism of @entity5 on electrophysiology in vivo in a @entity1 model of XXXX .

answer: @entity3


abstract: BACKGROUND: Major @entity3 is diagnosed in 18% of @entity0 following @entity4 ( @entity4 ), and the antidepressant @entity5 is shown to effectively decrease @entity3 and improve @entity2 prognosis. We observed the effect of @entity5 on cardiac electrophysiology in vivo in a @entity1 model of @entity4 and the potential mechanism. METHODS AND RESULTS: Eighty adult male @entity1 (200-250 g) were randomly assigned to five groups: normal control (control group), @entity4 ( @entity4 group), @entity3 ( @entity3 group), @entity4 (model group), and @entity4 treated with intragastric administration of 10 mg/kg @entity5 ( @entity5 group). @entity4 was induced by left anterior descending coronary artery ligation. @entity3 was developed by 4-week chronic mild stress (CMS). Behavior measurement was done before and during the experiment. Electrophysiology study in vivo and Western blot analysis were carried on after 4 weeks of CMS. After 4 weeks of CMS, @entity3 -like behaviors were observed in the @entity4 , @entity3 , and model groups, and chronic @entity5 administration could significantly improve those behaviors (P<0.05 vs model group). @entity5 significantly increased the @entity7 threshold compared with the model group (20.20  9.32 V vs 14.67  1.85 V, P<0.05). Expression of @entity9 was significantly reduced by 29%  12%, 24%  6%, and 41%  15%, respectively, in the @entity4 group, CMS group, and model group, which could be improved by @entity5 (30%  9%). But @entity5 showed no improvement on the @entity4 -induced loss of @entity8 . CONCLUSION: The susceptibility to @entity6 was @entity3 and @entity4 @entity1 , and @entity5 may reduce the incidence of @entity6 in @entity4 @entity1 and thus improve the prognosis. This may be related in part to the upregulation of @entity9 by @entity5 .

title: Effect and mechanism of XXXX on electrophysiology in vivo in a @entity1 model of @entity3 .

answer: @entity5


abstract: BACKGROUND: Major @entity3 is diagnosed in 18% of @entity0 following @entity4 ( @entity4 ), and the antidepressant @entity5 is shown to effectively decrease @entity3 and improve @entity2 prognosis. We observed the effect of @entity5 on cardiac electrophysiology in vivo in a @entity1 model of @entity4 and the potential mechanism. METHODS AND RESULTS: Eighty adult male @entity1 (200-250 g) were randomly assigned to five groups: normal control (control group), @entity4 ( @entity4 group), @entity3 ( @entity3 group), @entity4 (model group), and @entity4 treated with intragastric administration of 10 mg/kg @entity5 ( @entity5 group). @entity4 was induced by left anterior descending coronary artery ligation. @entity3 was developed by 4-week chronic mild stress (CMS). Behavior measurement was done before and during the experiment. Electrophysiology study in vivo and Western blot analysis were carried on after 4 weeks of CMS. After 4 weeks of CMS, @entity3 -like behaviors were observed in the @entity4 , @entity3 , and model groups, and chronic @entity5 administration could significantly improve those behaviors (P<0.05 vs model group). @entity5 significantly increased the @entity7 threshold compared with the model group (20.20  9.32 V vs 14.67  1.85 V, P<0.05). Expression of @entity9 was significantly reduced by 29%  12%, 24%  6%, and 41%  15%, respectively, in the @entity4 group, CMS group, and model group, which could be improved by @entity5 (30%  9%). But @entity5 showed no improvement on the @entity4 -induced loss of @entity8 . CONCLUSION: The susceptibility to @entity6 was @entity3 and @entity4 @entity1 , and @entity5 may reduce the incidence of @entity6 in @entity4 @entity1 and thus improve the prognosis. This may be related in part to the upregulation of @entity9 by @entity5 .

title: Effect and mechanism of @entity5 on electrophysiology in vivo in a XXXX model of @entity3 .

answer: @entity1