abstract: BACKGROUND/AIM: To investigate cold-induced autoinflammatory syndrome 1 ( @entity3 ) gene polymorphisms that cause @entity4 in @entity0 with @entity2 ( @entity2 ). MATERIALS AND METHODS: The study included 30 @entity0 diagnosed with @entity2 and 30 healthy age-matched individuals as a control group. @entity3 polymorphisms were assessed by DNA sequence analysis. @entity0 with @entity1 and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the @entity3 gene was analyzed separately in the @entity0 group. RESULTS: The most frequently observed polymorphisms in the @entity0 group were @entity5 in 83%, @entity6 in 23%, and @entity7 in 23% of the @entity0 . @entity5 polymorphism was evaluated separately. Guanine was transformed to adenine at the 732nd nucleotide position of the @entity3 gene in the cDNA of chromosome 1. CONCLUSION: The @entity3 gene @entity5 polymorphism was thought to be responsible for an increase in disease susceptibility. The frequency of the "A" allele is higher in the @entity0 group compared to the control group. @entity4 seem like a candidate to be one of these factors. This is the first report to define the role of @entity4 among these factors.

title: Evaluation of @entity4 genes in XXXX .

answer: @entity2


abstract: BACKGROUND/AIM: To investigate cold-induced autoinflammatory syndrome 1 ( @entity3 ) gene polymorphisms that cause @entity4 in @entity0 with @entity2 ( @entity2 ). MATERIALS AND METHODS: The study included 30 @entity0 diagnosed with @entity2 and 30 healthy age-matched individuals as a control group. @entity3 polymorphisms were assessed by DNA sequence analysis. @entity0 with @entity1 and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the @entity3 gene was analyzed separately in the @entity0 group. RESULTS: The most frequently observed polymorphisms in the @entity0 group were @entity5 in 83%, @entity6 in 23%, and @entity7 in 23% of the @entity0 . @entity5 polymorphism was evaluated separately. Guanine was transformed to adenine at the 732nd nucleotide position of the @entity3 gene in the cDNA of chromosome 1. CONCLUSION: The @entity3 gene @entity5 polymorphism was thought to be responsible for an increase in disease susceptibility. The frequency of the "A" allele is higher in the @entity0 group compared to the control group. @entity4 seem like a candidate to be one of these factors. This is the first report to define the role of @entity4 among these factors.

title: Evaluation of XXXX genes in @entity2 .

answer: @entity4


abstract: BACKGROUND _ AIMS: Endoscopic stents are placed for palliation of @entity2 . Although @entity1 ( @entity1 ) remain patent longer than plastic stents, they  are more expensive. We aimed to evaluate which type of stent  (plastic, uncovered @entity1 [uSEMS], or partially covered @entity1 [pcSEMS]) is the most effective and we assessed costs. METHODS: We performed a multicenter randomized trial in 219 @entity0 at 18 hospitals in The Netherlands from February 2008 through February 2013. @entity0 were assigned randomly for placement of a plastic stent (n  = 73), uSEMS (n  = 75), or pcSEMS (n  = 71) during endoscopic retrograde cholangiopancreatography. @entity0 were followed up for up to 1 year. Researchers were not blinded to groups. The main study end points included functional stent time and costs. RESULTS: The mean functional stent times were 172 days for plastic stents, 288 days for uSEMS, and 299 days for pcSEMS (P < .005 for uSEMS and pcSEMS vs plastic). The initial placement of plastic stents (   1042 or  1106) cost significantly less than placement of @entity1 (   1973 or  2094) (P  = .001). However, the total cost per @entity0 at the end of the follow-up period did not differ significantly between plastic stents (   7320 or  7770) and @entity1 (   6932 or  7356) (P  = .61). Furthermore, in @entity0 with short survival times ( <=3 mo) or metastatic disease, the total cost per @entity0 did not differ between plastic stents and @entity1 . No differences in costs were found between pcSEMS and uSEMS. CONCLUSIONS: Although placement of @entity1 (uncovered or partially covered) for palliation of @entity2 initially is more expensive than placement of plastic stents, @entity1 have longer functional time. The total costs after 1 year do not differ significantly with  stent type. Dutch Clinical Trial Registration no: NTR1361.

title: Cost Efficacy of Metal Stents for Palliation of XXXX in a Randomized Controlled Trial.

answer: @entity2


abstract: Titanium mesh cage (TMC) was introduced recently to provide anterior structural support and interbody fusion without the need to harvest bone from the iliac crest. Because of its good mechanical behavior and satisfactory clinical outcomes, TMC is commonly used for lumbar burst @entity2 . Here, we present a female @entity0 who underwent a posterior-anterior L4 corpectomy with TMC placement and developed a cage @entity2 after 42 months. The @entity0 refused the revision surgery and asked for conservative treatment. At the 3-month follow-up, she reported doing well, with no complaints of @entity3 or @entity1 . There were three cases of TMC @entity2 have been previously reported in the literature. Only one @entity0 performed a revision surgery with an expandable @entity4 cage, and all this three @entity0 experienced a good outcome during the follow-up period. TMC @entity2 is a rare complication of spinal surgery. Close observation or surgical treatment should be considered to improve @entity0 outcomes. Although cage placement, instability, subsidence, and both stress shielding and necrotic bone in the cage appear to play key roles in the pathogenesis of this rare complication, the exact mechanism of this condition remains undetermined.

title: XXXX mesh cage @entity2 after lumbar reconstruction surgery: a case report and literature review.

answer: @entity4


abstract: Titanium mesh cage (TMC) was introduced recently to provide anterior structural support and interbody fusion without the need to harvest bone from the iliac crest. Because of its good mechanical behavior and satisfactory clinical outcomes, TMC is commonly used for lumbar burst @entity2 . Here, we present a female @entity0 who underwent a posterior-anterior L4 corpectomy with TMC placement and developed a cage @entity2 after 42 months. The @entity0 refused the revision surgery and asked for conservative treatment. At the 3-month follow-up, she reported doing well, with no complaints of @entity3 or @entity1 . There were three cases of TMC @entity2 have been previously reported in the literature. Only one @entity0 performed a revision surgery with an expandable @entity4 cage, and all this three @entity0 experienced a good outcome during the follow-up period. TMC @entity2 is a rare complication of spinal surgery. Close observation or surgical treatment should be considered to improve @entity0 outcomes. Although cage placement, instability, subsidence, and both stress shielding and necrotic bone in the cage appear to play key roles in the pathogenesis of this rare complication, the exact mechanism of this condition remains undetermined.

title: @entity4 mesh cage XXXX after lumbar reconstruction surgery: a case report and literature review.

answer: @entity2


abstract: In Yugoslavia, @entity3 is the fourth most frequent @entity2 , after @entity1 , rectum, and @entity4 . Incidence of @entity3 in Croatia in 1975 was 6.0 per 100,000 population for males, and considerably less for females with 1.4 per 100,000 population. There is not a statistically significant difference in the incidence of @entity3 in the different regions within Croatia. During the period from March 1973 to April 1980 at the Central Institute for @entity1 and Allied Diseases in Zagreb, esophagoscopy was performed on 179 @entity0 with @entity1 . Test results of 170 @entity0 was 60.4 years (male 60.0, female 62.4). The authors present the analyses of histopathologic types of @entity1 . In 79.4% of @entity0 (135/170) @entity5 was found. In 69 @entity0 histologic findings were compared with cytology. In six @entity0 , only the cytological examinations were positive. Furthermore, the localizations of @entity1 in the esophagus were analyzed, and in 53.6% of @entity0 (91/170) @entity1 was localized in the middle third of the esophagus. In almost all cases the disease was advanced and inoperable. Smoking and @entity6 were analyzed as potential etiological factors. The authors consider that esophagoscopy could be a valuable method in the early detection of @entity3 in the high risk group of the population ( @entity0 over 50 years of age who are heavy alcoholics and smokers).

title: XXXX --the role of esophagoscopy.

answer: @entity1


abstract: Systematic investigations testing for the presence of @entity4 and @entity1 of the large bowel were conducted in a population of 1,369 inpatients and outpatients, aged 45-70 years, in eight university departments of gastroenterology or abdominal surgery (Toulouse, Dijon, Paris, Marseille, and Strasbourg). Double-contrast barium enema and proctosigmoidoscopy examinations were carried out in all cases, whereas total coloscopy was performed only in the case of detected @entity1 . A questionnaire including 233 parameters (age, sex, family, and personal history and symptoms) was completed for each @entity0 . A total of 414 lesions were detected in 252 @entity0 , including 245 @entity6 , 8 transformed @entity4 , and 30 @entity3 ; 3 of 4 lesions were located in the rectum or sigmoid. @entity1 or @entity6 were found in 13% of the @entity0 . The prevalence of these lesions in the population studied was increased in @entity0 with rectorrhagia (19%) or with a personal history of surgery for @entity2 or @entity4 (23%). In the @entity0 without rectorrhagia or a history of @entity5 , the incidence was 9.7%. It was significantly increased in males and @entity0 more than 50 year old. The efficacy of proctosigmoidoscopy and double-contrast barium enema was compared in 909 @entity0 . Sensitivity and specificity were, respectively, 35% and 99% for endoscopy, 96% and 94% for radiology.

title: A cooperative study on the detection of @entity2 and XXXX in France.

answer: @entity4


abstract: Systematic investigations testing for the presence of @entity4 and @entity1 of the large bowel were conducted in a population of 1,369 inpatients and outpatients, aged 45-70 years, in eight university departments of gastroenterology or abdominal surgery (Toulouse, Dijon, Paris, Marseille, and Strasbourg). Double-contrast barium enema and proctosigmoidoscopy examinations were carried out in all cases, whereas total coloscopy was performed only in the case of detected @entity1 . A questionnaire including 233 parameters (age, sex, family, and personal history and symptoms) was completed for each @entity0 . A total of 414 lesions were detected in 252 @entity0 , including 245 @entity6 , 8 transformed @entity4 , and 30 @entity3 ; 3 of 4 lesions were located in the rectum or sigmoid. @entity1 or @entity6 were found in 13% of the @entity0 . The prevalence of these lesions in the population studied was increased in @entity0 with rectorrhagia (19%) or with a personal history of surgery for @entity2 or @entity4 (23%). In the @entity0 without rectorrhagia or a history of @entity5 , the incidence was 9.7%. It was significantly increased in males and @entity0 more than 50 year old. The efficacy of proctosigmoidoscopy and double-contrast barium enema was compared in 909 @entity0 . Sensitivity and specificity were, respectively, 35% and 99% for endoscopy, 96% and 94% for radiology.

title: A cooperative study on the detection of XXXX and @entity4 in France.

answer: @entity2


abstract: Background MicroRNAs (miRNAs) are small, non-coding RNAs that may function as oncogenes or @entity1 suppressors. Previous studies have shown that the expression level of @entity3 was enhanced in multiple types of @entity1 . However, the expression of @entity3 in @entity0 @entity2 ( @entity2 ) and its prognostic values remain unclear. Material and Methods Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to analyze the expression of @entity3 in 106 pairs of matched normal and @entity1 tissue samples. The chi-square test was used to examine the associations between @entity3 expression and the clinicopathological characters. The survival curves were constructed by the Kaplan-Meier method. The influence of each clinical variable on survival was examined by the Cox multivariate regression analysis. Results The expression level of @entity3 was significantly higher in @entity1 tissues and @entity1 cell lines than in normal controls (p<0.01). High expression of @entity3 was found to significantly correlate with nodal status (p=0.015), TNM stage (p=0.005), and @entity1 grade (p=0.002). Enhanced @entity3 correlated significantly with @entity0 survival (p<0.01). In multivariate analysis, we found that @entity3 expression was an independent prognostic factor of poor @entity0 survival (p= 0.036; HR=2.82; 95% CI=1.07-7.43). Conclusions High @entity3 expression is associated with poor prognosis in @entity2 and may serve as a novel prognostic marker in @entity2 .

title: Expression and Clinical Significance of microRNA-1246 in @entity0 XXXX .

answer: @entity2


abstract: Background MicroRNAs (miRNAs) are small, non-coding RNAs that may function as oncogenes or @entity1 suppressors. Previous studies have shown that the expression level of @entity3 was enhanced in multiple types of @entity1 . However, the expression of @entity3 in @entity0 @entity2 ( @entity2 ) and its prognostic values remain unclear. Material and Methods Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to analyze the expression of @entity3 in 106 pairs of matched normal and @entity1 tissue samples. The chi-square test was used to examine the associations between @entity3 expression and the clinicopathological characters. The survival curves were constructed by the Kaplan-Meier method. The influence of each clinical variable on survival was examined by the Cox multivariate regression analysis. Results The expression level of @entity3 was significantly higher in @entity1 tissues and @entity1 cell lines than in normal controls (p<0.01). High expression of @entity3 was found to significantly correlate with nodal status (p=0.015), TNM stage (p=0.005), and @entity1 grade (p=0.002). Enhanced @entity3 correlated significantly with @entity0 survival (p<0.01). In multivariate analysis, we found that @entity3 expression was an independent prognostic factor of poor @entity0 survival (p= 0.036; HR=2.82; 95% CI=1.07-7.43). Conclusions High @entity3 expression is associated with poor prognosis in @entity2 and may serve as a novel prognostic marker in @entity2 .

title: Expression and Clinical Significance of microRNA-1246 in XXXX @entity2 .

answer: @entity0


abstract: CONTEXT: The surgical treatment of @entity7 includes percutaneous @entity8 and sequestrectomy in the late phase of the disease. OBJECTIVE: The aim of the study was to compare the conventional open necrosectomy (CON) approach with the alternative focused open necrosectomy (FON) approach in @entity0 with infected @entity1 and progression of @entity5 . METHODS: @entity0 with @entity6 were included in the study prospectively from January 2004 to July 2014. All @entity0 had been admitted with the first or a new @entity2 . Symptomatic large fluid collections were drained percutaneously. The step-up approach was used in @entity0 with several distant localizations of infected @entity1 . The methods were analysed by comparing the individual severity according to the ASA, APACHE II and SOFA scores, @entity4 rate, @entity3 rate and mortality. RESULTS: A total of 31 @entity0 were included in the FON group and 39 in the CON group. The incidence of @entity4 was similar in groups. More ASA III comorbid conditions, a higher APACHE II score, a more frequent need for renal replacement therapy was observed in the CON group. The @entity3 rate was in the range of 32% to 44%; mortality reached 6.5% in the FON group and 12.8% in the CON group. CONCLUSIONS: Comorbid conditions, organ failure, and @entity4 are the main risk factors in @entity0 with @entity7 . The step-up approach and perioperative ultrasonography navigation improves the clinical outcome and reduces the extent of invasive surgical intervention in @entity0 unsuited to other minimally invasive procedures.

title: Ultrasound-assisted focused open necrosectomy in the treatment of XXXX .

answer: @entity7


abstract: UNASSIGNED: @entity5 stress testing in conjunction with radionuclide myocardial perfusion imaging has become a common approach for the detection of @entity2 in @entity0 who are unable to perform adequate levels of exercise. However, specific electrocardiographic alterations during the test have been rarely described. Using a Chinese population, the aim of the present study was to provide a detailed electrocardiographic profile of @entity5 stress testing. The study population included 1,168 consecutive outpatients who had undergone @entity5 -induced stress myocardial perfusion imaging. Electrocardiographic data during and immediately following the @entity5 infusion were collected, and the corresponding myocardial perfusion images were assessed. During @entity5 infusion, 174 transient and 47 persistent arrhythmic events occurred in 110 @entity0 (9.42%). Furthermore, frequent premature @entity9 occurred in 65 individuals and frequent @entity7 were observed in 73 individuals. @entity4 ( @entity4 ) occurred in 75 @entity0 [first degree (I  ) @entity4 , 16; second degree (II  ) @entity4 , 58; third degree @entity4 , 1), while @entity8 occurred in eight @entity0 . ST @entity1 emerged in 69 @entity0 . @entity0 with a baseline I   @entity4 had an increased risk of a II   @entity4 , and @entity0 exhibiting @entity1 were more likely to have a further depressed ST segment during the stress test (odds ratio, 28.68 and 5.01, respectively; both P<0.001). Following @entity5 infusion, 10 @entity0 (0.86%) exhibited newly occurred arrhythmic events. However, no @entity0 presented with acute @entity3 or sudden mortality. In conclusion, the results demonstrated that @entity5 infusion was a safe method, despite the relatively high incidence of arrhythmic events. The majority of @entity6 that occurred during infusion were transient, were reversible with the termination of infusion and did not indicate abnormal perfusion results.

title: Electrocardiographic profile of XXXX pharmacological stress testing.

answer: @entity5


abstract: UNASSIGNED: The aim of this study was to explore whether bone marrow mononuclear cell (BMMC) transplantation is able to accelerate the bone remodeling induced by midpalatal expansion in @entity0 . A total of 48 male @entity0 (mean weight, 208.36  7.32 g) were divided into control and midpalatal expansion with or without BMMC transplantation groups. Histological and morphological changes were observed in each group. The osteogenic activities and differential potentials of the transplanted BMMCs labeled with @entity1 in the midpalatal bone tissue were assessed by @entity4 expression. The @entity2 ( @entity2 )/ @entity3 ( @entity3 ) ratio was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to reflect the equilibrium between bone resorption and formation. The results demonstrated that the width of the maxillary dental arch increased distinctly within 2 weeks of midpalatal expansion with BMMC transplantation. The morphology of the midpalatal suture in this group changed significantly; the cartilage was completely replaced by fibrous-like tissue expressing @entity4 . The palatal bone was reorganized from a cancellous form into a mature compact structure after an additional 2-week relapse period. Immunostaining results indicated that the heterologous transplanted BMMCs survived and differentiated into osteoblasts during the remodeling induced by midpalatal expansion. The @entity2 / @entity3 expression ratio significantly decreased after 2 weeks of midpalatal expansion with BMMC transplantation due to the inhibition of @entity2 expression. Heterologous BMMC transplantation appears to accelerate the midpalatal bone remodeling induced by expansion of the @entity0 through increasing the number of osteoprogenitor cells and regulating the @entity2 - @entity3 signaling pathway.

title: Effect of heterologous bone marrow mononuclear cell transplantation on midpalatal expansion in XXXX .

answer: @entity0


abstract: OBJECTIVES: The purpose of this study is to compare the effects of @entity3 venom pharmacopuncture (BVP) therapy according to the methods used to treat @entity2 ( @entity1 ): intra-acupoint combined with intra-articular injection, intra-acupoint injection, and intra-articular injection. METHODS: A total of 69 @entity0 were recruited by the Department of Acupuncture _ Moxibustion at Dong- Eui Oriental University Hospital from February 1 to July 23, 2012. The @entity0 were assigned to 3 groups: the first group with intra-acupoint combined with intraarticular BVP Injection (the experimental group), the 2nd group with intra-acupoint BVP injection (control group   ), and the 3rd group with intra-articular BVP injection (control group   ). The @entity0 were assigned in the order in which they were recruited. Treatments were done twice a week, for a total of 9 times. The effectiveness was assessed by using the visual analouge scale (VAS) and the Korea Western Ontario and McMaster Universities @entity1 Index (KWOMAC). RESULTS: All three groups exhibited significant VAS and KWOMAC effects. Moreover, the 4 week follow-up after the final treatment showed a persistence of BVP effects. However, when the groups were compared, no statistically significant differences in VAS and KWOMAC were noted, but when improvement was considered, the results showed that intra-articular injection was more effective than intra-acupoint injection. Especially, intra-acupoint combined with intra-articular injection was the most effective among the three treatments. CONCLUSIONS: Combining intra-acupoint with intraarticular injection, depending on the @entity0 's symptoms, may produce better results when conservatively treating knee @entity1 .

title: Comparative study on the effects of @entity3 venom pharmacopuncture according to the treatment method for XXXX .

answer: @entity2


abstract: OBJECTIVES: The purpose of this study is to compare the effects of @entity3 venom pharmacopuncture (BVP) therapy according to the methods used to treat @entity2 ( @entity1 ): intra-acupoint combined with intra-articular injection, intra-acupoint injection, and intra-articular injection. METHODS: A total of 69 @entity0 were recruited by the Department of Acupuncture _ Moxibustion at Dong- Eui Oriental University Hospital from February 1 to July 23, 2012. The @entity0 were assigned to 3 groups: the first group with intra-acupoint combined with intraarticular BVP Injection (the experimental group), the 2nd group with intra-acupoint BVP injection (control group   ), and the 3rd group with intra-articular BVP injection (control group   ). The @entity0 were assigned in the order in which they were recruited. Treatments were done twice a week, for a total of 9 times. The effectiveness was assessed by using the visual analouge scale (VAS) and the Korea Western Ontario and McMaster Universities @entity1 Index (KWOMAC). RESULTS: All three groups exhibited significant VAS and KWOMAC effects. Moreover, the 4 week follow-up after the final treatment showed a persistence of BVP effects. However, when the groups were compared, no statistically significant differences in VAS and KWOMAC were noted, but when improvement was considered, the results showed that intra-articular injection was more effective than intra-acupoint injection. Especially, intra-acupoint combined with intra-articular injection was the most effective among the three treatments. CONCLUSIONS: Combining intra-acupoint with intraarticular injection, depending on the @entity0 's symptoms, may produce better results when conservatively treating knee @entity1 .

title: Comparative study on the effects of XXXX venom pharmacopuncture according to the treatment method for @entity2 .

answer: @entity3


abstract: OBJECTIVES: To evaluate MRI findings in @entity0 with @entity3 ( @entity3 ) and to determine the value of MRI in the diagnosis of @entity3 and assessment of @entity2 . MATERIALS AND METHODS: This study reviewed the prevalence of @entity1 seen in 45 @entity3 @entity0 in the past four years, including 33 @entity0 who underwent liver biopsy. Correlation between the MRI findings and the pathological stage was determined. RESULTS: There were 33 @entity0 who underwent liver biopsy. Twenty-five @entity0 (75.8%) had non-homogeneous changes in the liver signal intensity, 25 (75.8%) had a periportal halo sign, and 29 (87.9%) had @entity4 . The short axis of the enlarged lymph nodes was a mean of 1.2  0.3 cm. A strong positive correlation was observed between histological stage and the inhomogeneity of liver signal intensity (P<0.001). There were significant differences among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stage (P<0.001). Grading of the periportal halo sign was significantly different at stage II versus III, and stage III versus IV; no significant difference was found between stages I and II. There were also no significant differences among the four histological states in the occurrence and size of enlarged lymph nodes (P=0.674 and P=0.394). CONCLUSION: MRI is valuable in the diagnosis of @entity3 , and the periportal halo sign and liver signal intensity help to evaluate the degree of @entity2 .

title: The Value of MRI in the Diagnosis of XXXX and @entity2 .

answer: @entity3


abstract: OBJECTIVES: To evaluate MRI findings in @entity0 with @entity3 ( @entity3 ) and to determine the value of MRI in the diagnosis of @entity3 and assessment of @entity2 . MATERIALS AND METHODS: This study reviewed the prevalence of @entity1 seen in 45 @entity3 @entity0 in the past four years, including 33 @entity0 who underwent liver biopsy. Correlation between the MRI findings and the pathological stage was determined. RESULTS: There were 33 @entity0 who underwent liver biopsy. Twenty-five @entity0 (75.8%) had non-homogeneous changes in the liver signal intensity, 25 (75.8%) had a periportal halo sign, and 29 (87.9%) had @entity4 . The short axis of the enlarged lymph nodes was a mean of 1.2  0.3 cm. A strong positive correlation was observed between histological stage and the inhomogeneity of liver signal intensity (P<0.001). There were significant differences among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stage (P<0.001). Grading of the periportal halo sign was significantly different at stage II versus III, and stage III versus IV; no significant difference was found between stages I and II. There were also no significant differences among the four histological states in the occurrence and size of enlarged lymph nodes (P=0.674 and P=0.394). CONCLUSION: MRI is valuable in the diagnosis of @entity3 , and the periportal halo sign and liver signal intensity help to evaluate the degree of @entity2 .

title: The Value of MRI in the Diagnosis of @entity3 and XXXX .

answer: @entity2


abstract: UNASSIGNED: Ocular signs in @entity3 have generally been regarded to be primarily of diagnostic value. We explored whether ocular findings, alone or in particular in combination with the a-galactosidase A gene mutation, have predictive value for disease severity. Data from the Fabry Outcome Survey (FOS), a large, global database sponsored by Shire, were selected for adult @entity0 who had undergone ophthalmological examination. Three ocular signs were assessed: @entity2 , tortuous conjunctival and/or retinal vessels, and @entity1 . @entity3 severity was measured using FOS Mainz Severity Score Index and modifications thereof. Ophthalmological data were available for 1203 (699 female, 504 male) adult @entity0 with eye findings characteristic of @entity3 in 55.1%. @entity2 had a similar distribution in @entity0 (51.1%) and @entity0 (50.8%), whereas tortuous vessels and @entity1 were somewhat more frequent in @entity0 than in @entity0 . @entity0 with @entity2 , selected as the principal ocular sign for this study, had more severe disease (median score, 20.0) versus those without ocular signs (11.0; P<0.001). This finding could be confirmed by applying age adjusted severity scores. Moreover, the prevalence of @entity2 was significantly higher in @entity0 with null (male, 76.9%; female, 64.5%) and missense (male, 79.2%; female, 67.4%) mutations versus mild missense (male, 17.1%; female, 23.1%) and the @entity4 (male, 15.0%; female, 15.6%) mutations (P<0.01). Our analyses show a correlation between the prevalence of ocular changes in @entity3 and disease severity. Consequently, information on ocular findings and a-galactosidase A gene mutation may help assess the risk for more severe @entity3 . These observed findings are of notable clinical importance, as @entity3 is characterized by high clinical course variability and only weak genotype-phenotype correlation at the individual @entity0 level. Further confirmatory studies are needed.

title: Ocular Signs Correlate Well with Disease Severity and Genotype in XXXX .

answer: @entity3


abstract: BACKGROUND: The need to integrate economic and epidemiological aspects in the clinical perspective leads to a proposal for the analysis of health disparities and to an evaluation of the health services and of the new challenges which are now being faced by health system reforms in middle income countries. OBJECTIVE: To identify the epidemiological changes, the demand for health services and economic burden from @entity3 ( @entity1 and @entity2 ) in a middle income county. METHODS: We conducted longitudinal analyses of costs and epidemiological changes for @entity1 and @entity2 in the Mexican health system. The study population included both the insured and uninsured populations. The cost-evaluation method was used, based on the instrumentation and consensus techniques. To estimate the epidemiological changes and financial consequences for 2014-2016, six models were constructed according to the Box-Jenkins technique, using confidence intervals of 95%, and the Box-Pierce test. RESULTS: Regarding epidemiological changes expected in both diseases for 2014 vs. 2016, an increase is expected, although results predict a greater increase for @entity1 , 8-12% in all three studied institutions, (p < .05). Indeed, in the case of @entity1 , the increase was 41469 cases for uninsured population (SSA) and 65737 for the insured population (IMSS and ISSSTE). On @entity2 cases the increase was 38109 for uninsured vs 62895 for insured. Costs in US  ranged from  699 to  748 for annual case management per @entity0 in the case of @entity1 , and from  485 to  622 in @entity0 with @entity2 . Comparing financial consequences of health services required by insured and uninsured populations, the greater increase (23%) will be for the insured population (p < .05). The financial requirements of both diseases will amount to 19.5% of the total budget for the uninsured and 12.5% for the insured population. CONCLUSIONS: If the risk factors and the different health care models remain as they currently are, the economic impact of expected epidemiological changes on the social security system will be particularly strong. Another relevant challenge is the appearance of internal competition in the use and allocation of financial resources with programs for other chronic and @entity4 .

title: Costs and Epidemiological Changes of XXXX : Implications and Challenges for Health Systems.

answer: @entity3


abstract: This study examined the effects of dietary saturated and polyunsaturated fat on the chemical composition and metabolism of low density lipoproteins (LDL) in eight normal male subjects. The influence of these diets on fecal @entity8 excretion was also measured in four of the subjects. When compared with the saturated fat diet, the polyunsaturated diet lowered both plasma @entity2 polyunsaturated diet lowered both plasma @entity2 (23%, P less than 0.001) and @entity3 (14%, P less than 0.001) levels. Sixty-seven percent of the reduction in the former lipid resulted from a fall in LDL @entity2 (23%, P less than 0.001), although very low density (VLDL) and high density lipoprotein (HDL) @entity2 levels also fell (by 27% and 20% of their respective control value). These changes were accompanied by significant alterations in LDL composition. Specifically, during polyunsaturated fat feeding, the relative percentage @entity2 in the LDL fraction fell while that of phospholipid rose. There was no change in the percentage protein or @entity3 . The @entity4 components of LDL @entity3 , @entity9 , and phospholipid were also affected by dietary fat saturation level. Overall, polyunsaturated fat feeding produced an enrichment in linoleate with reciprocal changes in @entity6 , stearate, and @entity7 which affected @entity5 more than @entity9 and phospholipids. The above changes in LDL composition were associated with alterations in the metabolism of LDL apoprotein (apoLDL). The polyunsaturated deit lowered plasma apoLDL by 13% (P less than 0.05). This resulted from an increase in the fractional catabolic rate of LDL (whether determined by plasma decay curve analysis (P less than 0.05) or urine/plasma radioactivity ratios (P less than 0.001) without significant alteration of its corporeal distribution or synthetic rate. The polyunsaturated fat diet did not cause a consistent change in fecal neutral or acidic @entity1 excretion. We conclude that the hypocholesterolemic action of polyunsaturated fat diets is effected by multiple mechanisms whose expression may vary from @entity0 to @entity0 .

title: Effects of saturated and polyunsaturated fat diets on the chemical composition and metabolism of low density lipoproteins in XXXX .

answer: @entity0


abstract: UNASSIGNED: The goal of this analysis was to determine the agreement between body mass index-based and cholesterol-based ten-year Framingham general @entity2 risk scores among a convenience sample of 773 South Asian Canadian adults attending community-based screening clinics. Scores were calculated using age, systolic blood pressure, antihypertensive use, current smoking, @entity1 , and total cholesterol and high density lipoprotein (for cholesterol-based risk) or height and weight (for body mass index-based risk). Mean risk score differences (body mass index-based risk minus cholesterol-based risk) were estimated using paired t-tests. Bland-Altman plots were used to assess agreement between scores. Finally, agreement across risk categories (low [<10%], moderate [10% to <20%], high [> = 20%]) was examined using the kappa statistic. Average agreement between the two risk scores was quite good overall (mean differences of 0.6% for @entity0 and 0.5% for @entity0 ), but increased to about 3% among @entity0 60-74 years of age. However, Bland-Altman plots revealed that the differences between the two scores and the variability of the differences increased with increasing average 10-year risk. In terms of clinical importance, the limits of agreement were reasonable for @entity0 < 60 years (95% confidence interval: -3.2% to 3.1%), but of concern for @entity0 60-74 years (95% confidence interval: -6.0% to 12.3%), @entity0 < 60 years (95% confidence interval: -7.1% to 7.3%) and @entity0 6-074 years (95% confidence interval: -13.8% to 18.8%). Agreement across categories was moderate for most sex and age groups examined (kappa values: 0.51 for @entity0 < 60 years, 0.50 for @entity0 60-74 years, 0.65 for @entity0 < 60 years), except for @entity0 60-74 years, where agreement was only fair (kappa = 0.26). In light of these disagreements, evaluation of a @entity0 's change in @entity2 risk over time will necessitate use of the same risk score (i.e., either body mass index-based or cholesterol-based) at all screening sessions.

title: Framingham Ten-Year General XXXX Risk: Agreement between BMI-Based and Cholesterol-Based Estimates in a South Asian Convenience Sample.

answer: @entity2


abstract: OBJECTIVE: The prospective efficacy of a future peripheral retinal prosthesis complementing residual vision to raise mobility performance in non-end stage @entity2 ( @entity2 ) was evaluated using simulated prosthetic vision (SPV). APPROACH: Normally sighted volunteers were fitted with a wide-angle head-mounted display and carried out mobility tasks in photorealistic virtual pedestrian scenarios. Circumvention of low-lying obstacles, path following, and navigating around static and moving pedestrians were performed either with central simulated residual vision of 10   alone or enhanced by assistive SPV in the lower and lateral peripheral @entity1 ( @entity1 ). Three layouts of assistive vision corresponding to hypothetical electrode array layouts were compared, emphasizing higher visual acuity, a wider visual angle, or eccentricity-dependent acuity across an intermediate angle. Movement speed, task time, distance walked and collisions with the environment were analysed as performance measures. MAIN RESULTS: Circumvention of low-lying obstacles was improved with all tested configurations of assistive SPV. Higher-acuity assistive vision allowed for greatest improvement in walking speeds-14% above that of @entity1 , while only wide-angle and eccentricity-dependent vision significantly reduced the number of collisions-both by 21%. Navigating around pedestrians, there were significant reductions in collisions with static pedestrians by 33% and task time by 7.7% with the higher-acuity layout. Following a path, higher-acuity assistive vision increased walking speed by 9%, and decreased collisions with stationary cars by 18%. SIGNIFICANCE: The ability of assistive peripheral prosthetic vision to improve mobility performance in @entity0 with constricted VFs has been demonstrated. In a prospective peripheral visual prosthesis, electrode array designs need to be carefully tailored to the scope of tasks in which a device aims to assist. We posit that maximum benefit might come from application alongside existing visual aids, to further raise life quality of @entity0 living through the prolonged early stages of @entity2 .

title: Towards an assistive peripheral visual prosthesis for long-term treatment of XXXX : evaluating mobility performance in immersive simulations.

answer: @entity2


abstract: As under-reporting of dietary intake, particularly by overweight and @entity1 subjects, is common in dietary surveys, biases inherent in the use of self-reported dietary information may distort true diet- @entity1 relationships or even create spurious ones. However, empirical evidence of this possibility is limited. The present cross-sectional study compared the relationships of 24 h urine-derived and self-reported intakes of @entity4 , @entity3 and protein with @entity1 . A total of 1043 Japanese @entity0 aged 18-22 years completed a 24 h urine collection and a self-administered diet history questionnaire. After adjustment for potential confounders, 24 h urine-derived @entity4 intake was associated with a higher risk of general @entity1 (BMI>= 25 kg/m2) and @entity2 (waist circumference>= 80 cm; both P for trend=0  04). For 24 h urine-derived protein intake, positive associations with general and @entity2 were observed (P for trend=0  02 and 0  053, respectively). For 24 h urine-derived K intake, there was an inverse association with @entity2 (P for trend=0  01). Conversely, when self-reported dietary information was used, only inverse associations between K intake and general and @entity2 were observed (P for trend=0  04 and 0  02, respectively), with no associations of @entity4 or protein intake. In conclusion, we found positive associations of @entity4 and protein intakes and inverse associations of K intake with @entity1 when using 24 h urinary excretion for estimating dietary intakes. However, no association was observed based on using self-reported dietary intakes, except for inverse association of K intake, suggesting that the ability of self-reported dietary information using the diet history questionnaire for investigating diet- @entity1 relationships is limited.

title: Ability of self-reported estimates of dietary sodium, potassium and protein to detect an association with general and XXXX : comparison with the estimates derived from 24  h urinary excretion.

answer: @entity2


abstract: CONTEXT: @entity2 are common among older adolescents and young adults; hence, STD screening is a public health priority. Home-based STD testing could be a strategy to improve screening rates, particularly among at-risk populations, including sexual minority (i.e., nonheterosexual) young adults. METHODS: Data were collected from a national sample of 971 sexual minority young adults aged 18-26 through an online survey in the fall of 2013. Logistic regression analyses identified associations between respondents' characteristics and their willingness to use a home-based test for @entity1 and @entity3 . RESULTS: A greater proportion of @entity0 than of @entity0 were willing to use a home-based STD test (81% vs. 68%). Willingness was more likely among gay than among bisexual @entity0 , among @entity0 insured through their parents than among the uninsured and among those who had had two or more sexual partners in the past year than among those who had had fewer (adjusted odds ratios, 2.0-2.2). Among @entity0 , students were less likely than the employed to report willingness for home-based testing (0.4). Among @entity0 , willingness was more likely among those who reported at least two partners in the past year than among those who reported fewer (1.6). Overall, respondents' most common concerns about home-based STD testing regarded test accuracy, their ability to do the test correctly and their preference to see a doctor for testing. CONCLUSIONS: Home-based STD testing may be a promising strategy for screening sexual minority young adults; understanding correlates of willingness and young adults' concerns may help inform self-testing programs.

title: Acceptability of home-based XXXX and @entity3 testing among a national sample of sexual minority young adults.

answer: @entity1


abstract: CONTEXT: @entity2 are common among older adolescents and young adults; hence, STD screening is a public health priority. Home-based STD testing could be a strategy to improve screening rates, particularly among at-risk populations, including sexual minority (i.e., nonheterosexual) young adults. METHODS: Data were collected from a national sample of 971 sexual minority young adults aged 18-26 through an online survey in the fall of 2013. Logistic regression analyses identified associations between respondents' characteristics and their willingness to use a home-based test for @entity1 and @entity3 . RESULTS: A greater proportion of @entity0 than of @entity0 were willing to use a home-based STD test (81% vs. 68%). Willingness was more likely among gay than among bisexual @entity0 , among @entity0 insured through their parents than among the uninsured and among those who had had two or more sexual partners in the past year than among those who had had fewer (adjusted odds ratios, 2.0-2.2). Among @entity0 , students were less likely than the employed to report willingness for home-based testing (0.4). Among @entity0 , willingness was more likely among those who reported at least two partners in the past year than among those who reported fewer (1.6). Overall, respondents' most common concerns about home-based STD testing regarded test accuracy, their ability to do the test correctly and their preference to see a doctor for testing. CONCLUSIONS: Home-based STD testing may be a promising strategy for screening sexual minority young adults; understanding correlates of willingness and young adults' concerns may help inform self-testing programs.

title: Acceptability of home-based @entity1 and XXXX testing among a national sample of sexual minority young adults.

answer: @entity3


abstract: OBJECTIVE: To investigate whether serum angiotensing-converting enzyme ( @entity1 ) and uterine artery Doppler (UAD) are useful markers as @entity2 ( @entity2 ) in a high-risk population. METHODS: @entity0 at risk of @entity2 (n   =   68) were subclassified as having @entity2 (n   =   8) or no @entity2 (n   =   60). Blood samples were obtained between 19 and 22 weeks of gestation. Doppler ultrasound of the uterine arteries was done at the time of blood sampling. Maternal serum @entity1 was determined through spectrophotometry assay (A15 Biosystem, ATOM, Barcelona, Spain). RESULTS: Comparing the group who presented @entity2 with the one who was not developed it, we found significant differences for @entity1 (54.2        21.2, 38.1        12.3 U/L; p   =   0.003); the pulsatility index (PI) (1.2        0, 3.1        0.3; p   =   0.032) and resistance index (RI) (0.7        0.1, 0.5        0.1; p   =   0.004). The AUC for @entity1 was 0.724, so we selected the cutoff of 36.5   U/L (sensitivity: 62.5% and specificity: 86.7%). The AUC for PI was 0.652 choosing a cutoff of 1.4 (sensitivity: 57.1% and specificity: 93.1%). The AUC for RI was 0.712 and the cutoff of 0.7 (sensitivity of 71.4% and specificity: 89.6%). The combination that allowed us to increase the diagnostic performance was the @entity1 +RI with Doppler study, increasing the AUC to 0.872. CONCLUSIONS: @entity1 , PI and RI as parameters of Doppler study were useful predictors of @entity2 in the second trimester of gestation. The best combination to increase the diagnostic performance was @entity1 with the RI.

title: Second trimester angiotensing-converting enzyme and uterine artery Doppler as XXXX in a high-risk population.

answer: @entity2


abstract: UNASSIGNED: @entity6 ( @entity6 ), the most common and severe type of dystrophinopathy, is an @entity3 caused by the absence of dystrophin, which leads to @entity7 and vulnerability of the sarcolemma to mechanical stretching with increased membrane permeability. Currently, glucocorticoids such as @entity2 are the only medication available for @entity6 . However, molecular pathways responsible for this effect are still unclear. In addition, it remains unclear whether sex-related factors, including pregnancy and the postpartum period, affect the phenotype of dystrophinopathy. Here, we report the amelioration of muscle membrane permeability in the diaphragm muscle of pregnant and postpartum, but not in nulliparous, mdx @entity0 , an animal model for @entity6 , during the physiological surge of @entity8 , the most abundant glucocorticoid in rodents. Cultures of single muscle fibers and myotubes isolated from mdx @entity0 diaphragm demonstrate resistance to @entity5 when treated with @entity8 but not with @entity1 or @entity4 . This @entity8 -mediated resistance was diminished by an antagonist of @entity8 , indicating that the glucocorticoid-glucocorticoid receptor axis plays a role in this membrane stabilization effect on muscle. Moreover, subcutaneous injection of @entity8 into mdx @entity0 showed decreased membrane permeability. This is the first report to demonstrate that pregnancy-related resistance to muscle fiber damage in mdx @entity0 due to the membrane stabilization effect of @entity8 . We also propose that this membrane stabilization effect is exerted through @entity10 up-regulation as the molecular mechanisms of glucocorticoid effects on @entity6 muscle. Furthermore, single muscle fiber culture studies provide a sensitive chemical screening platform for @entity9 .

title: Pregnancy-Induced Amelioration of XXXX Phenotype in mdx @entity0 via Muscle Membrane Stabilization Effect of Glucocorticoid.

answer: @entity9


abstract: UNASSIGNED: @entity6 ( @entity6 ), the most common and severe type of dystrophinopathy, is an @entity3 caused by the absence of dystrophin, which leads to @entity7 and vulnerability of the sarcolemma to mechanical stretching with increased membrane permeability. Currently, glucocorticoids such as @entity2 are the only medication available for @entity6 . However, molecular pathways responsible for this effect are still unclear. In addition, it remains unclear whether sex-related factors, including pregnancy and the postpartum period, affect the phenotype of dystrophinopathy. Here, we report the amelioration of muscle membrane permeability in the diaphragm muscle of pregnant and postpartum, but not in nulliparous, mdx @entity0 , an animal model for @entity6 , during the physiological surge of @entity8 , the most abundant glucocorticoid in rodents. Cultures of single muscle fibers and myotubes isolated from mdx @entity0 diaphragm demonstrate resistance to @entity5 when treated with @entity8 but not with @entity1 or @entity4 . This @entity8 -mediated resistance was diminished by an antagonist of @entity8 , indicating that the glucocorticoid-glucocorticoid receptor axis plays a role in this membrane stabilization effect on muscle. Moreover, subcutaneous injection of @entity8 into mdx @entity0 showed decreased membrane permeability. This is the first report to demonstrate that pregnancy-related resistance to muscle fiber damage in mdx @entity0 due to the membrane stabilization effect of @entity8 . We also propose that this membrane stabilization effect is exerted through @entity10 up-regulation as the molecular mechanisms of glucocorticoid effects on @entity6 muscle. Furthermore, single muscle fiber culture studies provide a sensitive chemical screening platform for @entity9 .

title: Pregnancy-Induced Amelioration of @entity9 Phenotype in mdx XXXX via Muscle Membrane Stabilization Effect of Glucocorticoid.

answer: @entity0


abstract: PURPOSE: To evaluate the impact of renal chimney grafts on anatomical suitability for @entity1 repair (EVAR) in @entity2 ( @entity2 ). METHODS: Contrast-enhanced computed tomography images of 206 @entity0 with @entity2 [175 @entity0 (mean age 75  7.8 years) and 31 @entity0 (mean age of 76  7.5 years)] were evaluated in a dedicated 3-dimensional vascular workstation. Assessment of infrarenal EVAR suitability was based on predefined anatomical variables reflecting the Instructions for Use of commercially available stent-grafts. In @entity0 where @entity1 neck length was the only limiting factor for suitability, reevaluation of the proximal sealing zone was done, accounting for chimney grafts in one or both renal arteries. RESULTS: Seventy (34%) @entity2 @entity0 were anatomically suitable for EVAR: 65 (37%) of 175 @entity0 and 5 (16%) of 31 @entity0 (p<0.01). Eighty-nine (65%) of the 136 unsuitable @entity0 had @entity1 necks <15 mm long; short neck was the only exclusion criterion in 33 (24%) cases. In the 33 short-necked @entity1 without other limiting factors, a proximal sealing zone >15 mm could potentially be achieved with one or two renal chimney grafts in 12 (36%) and 25 (76%) @entity0 , respectively, increasing overall suitability to 40% and 46%. If access issues could also be solved and a similar strategy with chimneys for the renal arteries was applied, the EVAR suitability would increase further to 58%. CONCLUSION: Roughly one third of @entity0 with @entity2 are anatomically suitable for EVAR; short @entity1 neck is the most common exclusion criteria. In appropriate cases, chimney grafts in one or both renal arteries may increase overall suitability by 12%. Suitability increases to ~60% when iliac access issues are additionally overcome.

title: Impact of Renal Chimney Grafts on Anatomical Suitability for Endovascular Repair in XXXX .

answer: @entity2


abstract: INTRODUCTION: Proper treatment of @entity3 @entity0 is crucial for long-term control of the disease. OBJECTIVE: The aim of the study was to evaluate the treatment of adult @entity3 @entity0 by primary care physicians in the light of international GINA guidelines. MATERIAL AND METHOD: The cross-sectional study included a representative sample of 1852 general practitioners (GPs) who were asked to complete questionnaires on the diagnosis and treatment often consecutive @entity0 with @entity3 who are under their care. RESULTS: Altogether 1250 GPs provided information about 10,981 @entity0 . During the entire duration of the disease 50.9% were ever treated by systemic @entity2 . In the current treatment of @entity3 inhaled @entity1 were used in 78.8% of cases, oral @entity1 in 5.8%, intravenous @entity1 in 1.3% and intramuscular @entity1 in 0.7% of @entity0 . @entity6 were used in 63.1% of @entity0 , LABA in 57.1%, @entity4 in 25.1%, @entity5 modifiers in 21.1%, anticholinergics drugs in 15.5%, cromones in 1,9%, and antihistamines in 23.1% of adult @entity0 with @entity3 . In 88.8% cases LABA treatment was combined with inhaled corticosteroids. In 83.8% of cases therapeutic regimens were in line with the GINA guidelines. CONCLUSIONS: There is a need for systematic educational activities addressed to primary care physicians.

title: [Treatment of XXXX in Poland by primary care physicians--results of PulmoScreen study].

answer: @entity3


abstract: OBJECTIVE: To evaluate the efficiency of ultrasound diagnosis in detecting and staging @entity5 . MATERIAL AND METHODS: An ultrasound study (USS) was conducted in 120 @entity0 aged 19 to 84 years with @entity5 . The @entity0 were divided into 3 groups by the location of a @entity2 process: 1) 47 (39.2%) @entity0 with @entity2 ; 2) 49 (40.8%) with portal duct or @entity9 ; 3) 24 (20%) with distal one. Ninety (75%) @entity0 were operated on; the others underwent minimally invasive X-ray surgical interventions as percutaneous transhepatic cholangiostomies. The data of ultrasound diagnosis were compared with the results of other studies, intraoperative assessment and morphological examination of a removed gross specimen. RESULTS: A @entity2 was detectable by USS only in 90 (75%) @entity0 ; its sensitivity was 100% for @entity5 ; 69.4 and 37.5% for portal duct and distal ones, respectively. It is most difficult to diagnose @entity4 of the common bile duct. USS reveals no semiotic signs of @entity5 , which could distinguish the latter from other @entity3 . The specific features of the infiltrative growth of a @entity6 , such as hyperechoic infiltration along the external outlines of the ducts or @entity8 during thickening of the duct walls, were ascertained. The sensitivity of intraoperative USS in identifying @entity7 was 100%. That of USS in detecting lymph node @entity1 was 61%; developed the semiotics of altered metastatic lymph nodes. CONCLUSION: The findings have indicated the high informative value of ultrasound diagnosis in determining the dilatation of the bile ducts and the spread of a @entity2 to the liver and lymph nodes. It is recommended that the indications for intraoperative USS should be expanded in @entity5 to define the extent of @entity4 .

title: [Efficiency of ultrasound study in the diagnosis of XXXX ].

answer: @entity5


abstract: Cardiac vagal preganglionic somata were labeled in @entity1 by the horseradish peroxidase (HRP) technique. The anatomical characteristics of cell bodies with axons in the left and right cervical vagi compared. HRP was injected subepicardially in three groups of @entity4 anesthetized animals. In two test groups, injections were made after a left and right cervical vagotomy, respectively. In a control group, peripheral @entity0 were performed prior to HRP injection. The controls served to determine the number of somata labeled by HRP uptake via vagal fibers innervating viscera closely approximating the myocardium. After a 48 h survival period the @entity1 were reanesthetized, perfused and fixed. Brain stems were removed, cut in the transverse or sagittal plane and developed with @entity5 . Control @entity1 had 6.8% the number of labeled cell bodies identified in animals with an intact vagus. Thus, few labeled somata in test @entity1 were associated with noncardia tissue. The number, distribution and sizes of labeled cell bodies in test @entity1 were similar. Somata were located ipsilateral to the intact vagus in three regions: the nucleus ambiguus (NA), the dorsal motor nucleus of the vagus ( @entity2 ) and an intermediate zone (IZ) between the NA and @entity2 . The NA contained the maximum number of cell bodies while successively fewer somata were located in the @entity2 and IZ. Somata of the NA were heterogeneously distributed along the @entity3 . The region of maximal cell body concentration was between 1.0 and 1.8 mm rostral to the obex. Somata of the @entity2 and IZ were homogeneously and sparsely distributed along the neuraxis. The long and short axes of NA somata were larger than corresponding dimensions of cell bodies in the @entity2 or IZ. However, the dimensions of somata in the @entity2 and IZ were similar. The identification of labeled cell bodies in three medullary regions and the size differences of the somata in these regions may reflect a central physiological organization of cardia vagal somata.

title: Horseradish peroxidase localization of XXXX .

answer: @entity0


abstract: PURPOSE: We designed the present study to investigate differences in prognostic factors and failure patterns between @entity1 with invasive @entity3 or @entity3 with micropapillary component (IMPC) and randomly matched @entity1 with @entity4 ( @entity4 ) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). MATERIALS AND METHODS: This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female @entity1 who had undergone curative resection for @entity0 without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age (    3  years), pathologic @entity2 and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution. RESULTS: A total of 534 @entity1 were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in @entity4 (P  < .001, P  =  .01, respectively). During the follow-up period, recurrences developed in 40 @entity1 with IMPC (15.0%) and 21 with @entity4 (7.9%). Locoregional recurrence (LRR) developed in 22 @entity1 with IMPC (8.2%) and 10 with @entity4 (3.7%). The rate of distant metastasis did not differ between the 2 groups (P  = .52). LRR-free survival (P  = .03) and recurrence-free survival (P  = .007) were significantly different between the 2 groups, but overall survival was not (P  = .67). CONCLUSION: IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to @entity4 . Modification of the locoregional treatment modality might be needed in this pathologic subtype of @entity0 .

title: Differences in Prognostic Factors and Failure Patterns Between Invasive XXXX and @entity3 With @entity4 of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06).

answer: @entity3


abstract: PURPOSE: We designed the present study to investigate differences in prognostic factors and failure patterns between @entity1 with invasive @entity3 or @entity3 with micropapillary component (IMPC) and randomly matched @entity1 with @entity4 ( @entity4 ) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). MATERIALS AND METHODS: This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female @entity1 who had undergone curative resection for @entity0 without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age (    3  years), pathologic @entity2 and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution. RESULTS: A total of 534 @entity1 were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in @entity4 (P  < .001, P  =  .01, respectively). During the follow-up period, recurrences developed in 40 @entity1 with IMPC (15.0%) and 21 with @entity4 (7.9%). Locoregional recurrence (LRR) developed in 22 @entity1 with IMPC (8.2%) and 10 with @entity4 (3.7%). The rate of distant metastasis did not differ between the 2 groups (P  = .52). LRR-free survival (P  = .03) and recurrence-free survival (P  = .007) were significantly different between the 2 groups, but overall survival was not (P  = .67). CONCLUSION: IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to @entity4 . Modification of the locoregional treatment modality might be needed in this pathologic subtype of @entity0 .

title: Differences in Prognostic Factors and Failure Patterns Between Invasive @entity3 and XXXX With @entity4 of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06).

answer: @entity3


abstract: PURPOSE: We designed the present study to investigate differences in prognostic factors and failure patterns between @entity1 with invasive @entity3 or @entity3 with micropapillary component (IMPC) and randomly matched @entity1 with @entity4 ( @entity4 ) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG). MATERIALS AND METHODS: This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female @entity1 who had undergone curative resection for @entity0 without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age (    3  years), pathologic @entity2 and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution. RESULTS: A total of 534 @entity1 were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in @entity4 (P  < .001, P  =  .01, respectively). During the follow-up period, recurrences developed in 40 @entity1 with IMPC (15.0%) and 21 with @entity4 (7.9%). Locoregional recurrence (LRR) developed in 22 @entity1 with IMPC (8.2%) and 10 with @entity4 (3.7%). The rate of distant metastasis did not differ between the 2 groups (P  = .52). LRR-free survival (P  = .03) and recurrence-free survival (P  = .007) were significantly different between the 2 groups, but overall survival was not (P  = .67). CONCLUSION: IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to @entity4 . Modification of the locoregional treatment modality might be needed in this pathologic subtype of @entity0 .

title: Differences in Prognostic Factors and Failure Patterns Between Invasive @entity3 and @entity3 With XXXX of the Breast: Retrospective Multicenter Case-Control Study (KROG 13-06).

answer: @entity4


abstract: Difficulties in @entity2 ( @entity2 ) are commonly experienced in everyday life situations. Here we investigate the neurocognitive mechanisms of @entity2 and the specific role of left angular gyrus. Given that previous behavioral research reported @entity0 to be more susceptible to left-right @entity1 , the current study focuses particularly on the neural basis of sex differences in @entity2 while controlling for potential menstrual cycle effects (repeated measures design). 16 @entity0 and 15 @entity0 were presented pictures of pointing hands in various orientations (rotated versus non-rotated) and were asked to identify them as left or right hands. Results revealed that @entity2 was particularly associated with activation in inferior parietal regions, extending into the right angular gyrus. Irrespective of menstrual cycle phase, @entity0 , relative to @entity0 , recruited more prefrontal areas, suggesting higher top-down control in @entity2 . For the subset of rotated stimuli as compared to the non-rotated, we found leftward asymmetry for both @entity0 and @entity0 , although @entity0 scored significantly lower. We conclude that there are sex differences in the neurocognitive mechanisms underlying @entity2 . Although the angular gyrus is involved in @entity2 , several other parietal areas are at least as critical. Moreover, the hypothesis that more left-right @entity1 is due to more bilateral activation (in @entity0 ) can be rejected.

title: The neural correlates of sex differences in left-right XXXX .

answer: @entity1


abstract: Molecularly targeted therapy emerged as a novel therapeutic strategy in the treatment of @entity1 . In the present study, we have developed gemcitabine (GEM)-loaded cetuximab (CET) surface modified poly(lactic) acid (PLA) nanoparticles (NP) (CET-GEM/PLA NP) to target to @entity2 ( @entity2 ) overexpressing @entity3 (A549) cells. The resultant CET-GEM/PLA NP showed a very uniform particle size of   120nm and spherical morphology. It exhibited a pH-dependent controlled release pattern. A sustained release of drug in the physiological conditions and faster release in @entity1 pH will greatly improve the chemotherapeutic efficiency of therapeutic system. Higher or enhanced cellular uptake of CET-GEM/PLA NP in A549 @entity1 cells clearly indicates the @entity2 -mediated receptor based active targeting. Nearly, a two-fold increase in fluorescent intensity was observed for CET-GEM/PLA NP comparing to that of non-targeted NP in the @entity1 cells. @entity2 -mediated internalization of the targeted NP was further confirmed by the confocal microscopy. MTT assay clearly showed the enhanced cell killing effect of CET-conjugated NP due to the selective delivery of GEM to the @entity2 over expressing @entity1 cells. Finally, comparing to the non-targeted NP, CET-GEM/PLA NP showed greater level of cell apoptosis (early and late apoptosis   40%). Our results showed that antibody conjugation on the surface of NP could be a potential treatment strategy for @entity2 over expressing @entity1 cells. This suggests that CET-GEM/PLA NP could be potentially used for the treatment of NSCLC ( @entity0 ).

title: Molecularly targeted gemcitabine-loaded nanoparticulate system towards the treatment of @entity2 overexpressing XXXX .

answer: @entity0


abstract: Molecularly targeted therapy emerged as a novel therapeutic strategy in the treatment of @entity1 . In the present study, we have developed gemcitabine (GEM)-loaded cetuximab (CET) surface modified poly(lactic) acid (PLA) nanoparticles (NP) (CET-GEM/PLA NP) to target to @entity2 ( @entity2 ) overexpressing @entity3 (A549) cells. The resultant CET-GEM/PLA NP showed a very uniform particle size of   120nm and spherical morphology. It exhibited a pH-dependent controlled release pattern. A sustained release of drug in the physiological conditions and faster release in @entity1 pH will greatly improve the chemotherapeutic efficiency of therapeutic system. Higher or enhanced cellular uptake of CET-GEM/PLA NP in A549 @entity1 cells clearly indicates the @entity2 -mediated receptor based active targeting. Nearly, a two-fold increase in fluorescent intensity was observed for CET-GEM/PLA NP comparing to that of non-targeted NP in the @entity1 cells. @entity2 -mediated internalization of the targeted NP was further confirmed by the confocal microscopy. MTT assay clearly showed the enhanced cell killing effect of CET-conjugated NP due to the selective delivery of GEM to the @entity2 over expressing @entity1 cells. Finally, comparing to the non-targeted NP, CET-GEM/PLA NP showed greater level of cell apoptosis (early and late apoptosis   40%). Our results showed that antibody conjugation on the surface of NP could be a potential treatment strategy for @entity2 over expressing @entity1 cells. This suggests that CET-GEM/PLA NP could be potentially used for the treatment of NSCLC ( @entity0 ).

title: Molecularly targeted gemcitabine-loaded nanoparticulate system towards the treatment of XXXX overexpressing @entity0 .

answer: @entity2


abstract: 1. This paper reports regional cerebral blood flow ( @entity5 ) measurements in 254 cortical regions with 133Xe injected into the internal carotid artery in 19 @entity0 , none of whom had any major @entity1 . The purpose was to demonstrate the pattern of cortical activity, as revealed by @entity5 increases, during two types of unilateral @entity2 in extrapersonal space: a) the maze test, series of fast @entity2 in various directions in a frame, executed under verbal command; and b) the drawing of a spiral in the air. 2. Both types of movements were associated with increases of @entity5 in the supplementary motor area (bilaterally), the convexity part of the premotor area (bilaterally), the primary sensorimotor hand and arm area (contralaterally), and in the superior and inferior parietal region (bilaterally). 3. During the maze test there were, in addition, bilateral focal increases of the blood flow in the auditory areas, the @entity4 . 4. It is concluded that the supplementary motor areas, which are also active during programming and execution of movement sequences in intrapersonal space (33), elaborate programs for motor subroutines necessary in skilled @entity3 . The convexity parts of the premotor areas are activated when a new motor program is established or a previously learned motor program is modulated. The primary motor area is the exclusive executive locus for @entity2 of the hand and arm. 5. @entity2 in extrapersonal space only are associated with activation of the parietal regions. These areas are assumed to provide information to the motor programming neurons about the demanded direction of motion in extrapersonal space in relation to proprioceptive reference systems. 6. The increase of @entity5 in the auditory areas, the @entity4 during the maze test were ascribed to the processing of auditory information. 7. Both tests are accompanied by a diffuse increase of the hemispheric blood flow (approximately 10%), which is assumed to be a parallel to the commonly known desynchronization of the EEG during mental work.

title: Different cortical areas in @entity0 in organization of XXXX in extrapersonal space.

answer: @entity2


abstract: 1. This paper reports regional cerebral blood flow ( @entity5 ) measurements in 254 cortical regions with 133Xe injected into the internal carotid artery in 19 @entity0 , none of whom had any major @entity1 . The purpose was to demonstrate the pattern of cortical activity, as revealed by @entity5 increases, during two types of unilateral @entity2 in extrapersonal space: a) the maze test, series of fast @entity2 in various directions in a frame, executed under verbal command; and b) the drawing of a spiral in the air. 2. Both types of movements were associated with increases of @entity5 in the supplementary motor area (bilaterally), the convexity part of the premotor area (bilaterally), the primary sensorimotor hand and arm area (contralaterally), and in the superior and inferior parietal region (bilaterally). 3. During the maze test there were, in addition, bilateral focal increases of the blood flow in the auditory areas, the @entity4 . 4. It is concluded that the supplementary motor areas, which are also active during programming and execution of movement sequences in intrapersonal space (33), elaborate programs for motor subroutines necessary in skilled @entity3 . The convexity parts of the premotor areas are activated when a new motor program is established or a previously learned motor program is modulated. The primary motor area is the exclusive executive locus for @entity2 of the hand and arm. 5. @entity2 in extrapersonal space only are associated with activation of the parietal regions. These areas are assumed to provide information to the motor programming neurons about the demanded direction of motion in extrapersonal space in relation to proprioceptive reference systems. 6. The increase of @entity5 in the auditory areas, the @entity4 during the maze test were ascribed to the processing of auditory information. 7. Both tests are accompanied by a diffuse increase of the hemispheric blood flow (approximately 10%), which is assumed to be a parallel to the commonly known desynchronization of the EEG during mental work.

title: Different cortical areas in XXXX in organization of @entity2 in extrapersonal space.

answer: @entity0


abstract: INTRODUCTION: The presence of a new autoantibody system, anti-carbamylated protein (anti- @entity4 ) antibodies, has been identified in @entity1 ( @entity1 ). The presence of anti- @entity4 antibodies was evaluated in samples taken from individuals who subsequently developed @entity1 before and after onset of symptoms and related to previously analysed antibodies against citrullinated peptides ( @entity2 specificities) and anti- @entity3 . METHODS: A total of 252 individuals, with 423 samples from before onset of symptoms of @entity1 , and 197 population controls were identified as donors to the Medical Biobank of Northern Sweden; 192 of them were also sampled at the time of diagnosis. All samples were analysed for anti- @entity4 IgG and anti- @entity3 antibodies using ELISAs. Ten different antibody reactivities against citrullinated antigens ( @entity2 specificities) were analysed using a custom-made microarray based on the ImmunoCAP ISAC system (Phadia). RESULTS: The concentration of anti- @entity4 antibodies was significantly increased in the pre-symptomatic individuals compared with controls (P <0.001) and also increased significantly after disease onset (P <0.001). The sensitivity for anti- @entity4 antibodies in the pre-symptomatic individuals was 13.9% (95% CI: 11 to 17.6) and 42.2% (95% CI: 35.4 to 49.3) following development of @entity1 . Anti- @entity4 antibody positivity was found in 5.1% to 13.3% of individuals negative for anti- @entity3 or @entity2 specificities. Presence of anti- @entity4 antibodies was significantly related to radiological destruction at baseline, at 24  months and also to radiological change (P <0.05, all). CONCLUSIONS: The results indicate that anti- @entity4 antibodies are associated with disease development, even after adjusting for the presence of different @entity2 fine specificities, and in anti- @entity3 negative individuals and contribute to the identification of a subset of @entity0 with worse radiological progression of the disease independent of @entity2 .

title: Anti-carbamylated protein antibodies in the pre-symptomatic phase of XXXX , their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage.

answer: @entity1


abstract: UNASSIGNED: Although @entity6 (CZ) has clinical activity in ALK (+) @entity4 ( @entity4 ), relapse is common due to the development of resistance. ALK and components of signalling pathways involved in resistance are client proteins of the chaperone, @entity5 , offering an alternative method for targeting the disease. Onalespib[ @entity2 ]( @entity7 ), a potent 2nd generation @entity5 inhibitor had anti- @entity1 activity in CZ-sensitive and CZ-resistant xenograft models when combined with CZ (Courtin et al). Importantly, when combined upfront with CZ in a CZ-sensitive xenograft model, @entity2 delayed the emergence of resistance observed with CZ monotherapy (Smyth et al.). These preclinical data suggest therapeutic potential for an @entity2 /CZ combination in CZ-sensitive and -resistant disease. This is currently being investigated in a 3-part Phase1/2 randomised @entity4 study. The primary objectives of the Phase 1 part of the clinical study were the safety and tolerability of CZ and @entity2 and selection of the recommended phase 2 dose (RP2D) of @entity2 . A rolling six design was used to determine the maxiumum tolerated dose (MTD)/RP2D of the combination. @entity0 received 250 mg BID oral CZ and IV @entity2 weekly for 3 of 4 weeks of a 28 day cycle (dosing cohorts 150, 180 or 220 mg/m(2)). In Part A, 32 @entity0 , who had prior CZ treatment, were treated with the combination in 3 dosing cohorts. @entity2 was escalated up to 220 mg/m(2) without DLTs and the combination was well tolerated ( @entity3 was the only @entity2 -related AE >=  Grade 3 in > 5% of @entity0 ). The mean number of @entity2 cycles was 4.2 (range 1-11+). @entity2 exposures were similar to previous studies and CZ exposures were unaffected when co-administered with @entity2 . Of 25 evaluable @entity0 , there were 4 PR and over 50% of subjects had a decrease in @entity1 size. CZ/ @entity2 doses of 250 mg BID/220 mg/m(2) were selected as the combination RP2D (Besse et al.). Preclinical data suggest that a CZ/ @entity2 combination has potential, upfront, to delay the emergence of resistance to CZ or, after relapse, to overcome resistance. A RP2D has been selected to continue evaluation of these hypotheses in Phase 2 studies of this combination in @entity0 prior to or after progression on CZ.

title: O3.6Combination of @entity5 inhibitor onalespib with XXXX to treat or delay resistance in @entity4 : Preclinical and Clinical Investigations.

answer: @entity6


abstract: UNASSIGNED: Although @entity6 (CZ) has clinical activity in ALK (+) @entity4 ( @entity4 ), relapse is common due to the development of resistance. ALK and components of signalling pathways involved in resistance are client proteins of the chaperone, @entity5 , offering an alternative method for targeting the disease. Onalespib[ @entity2 ]( @entity7 ), a potent 2nd generation @entity5 inhibitor had anti- @entity1 activity in CZ-sensitive and CZ-resistant xenograft models when combined with CZ (Courtin et al). Importantly, when combined upfront with CZ in a CZ-sensitive xenograft model, @entity2 delayed the emergence of resistance observed with CZ monotherapy (Smyth et al.). These preclinical data suggest therapeutic potential for an @entity2 /CZ combination in CZ-sensitive and -resistant disease. This is currently being investigated in a 3-part Phase1/2 randomised @entity4 study. The primary objectives of the Phase 1 part of the clinical study were the safety and tolerability of CZ and @entity2 and selection of the recommended phase 2 dose (RP2D) of @entity2 . A rolling six design was used to determine the maxiumum tolerated dose (MTD)/RP2D of the combination. @entity0 received 250 mg BID oral CZ and IV @entity2 weekly for 3 of 4 weeks of a 28 day cycle (dosing cohorts 150, 180 or 220 mg/m(2)). In Part A, 32 @entity0 , who had prior CZ treatment, were treated with the combination in 3 dosing cohorts. @entity2 was escalated up to 220 mg/m(2) without DLTs and the combination was well tolerated ( @entity3 was the only @entity2 -related AE >=  Grade 3 in > 5% of @entity0 ). The mean number of @entity2 cycles was 4.2 (range 1-11+). @entity2 exposures were similar to previous studies and CZ exposures were unaffected when co-administered with @entity2 . Of 25 evaluable @entity0 , there were 4 PR and over 50% of subjects had a decrease in @entity1 size. CZ/ @entity2 doses of 250 mg BID/220 mg/m(2) were selected as the combination RP2D (Besse et al.). Preclinical data suggest that a CZ/ @entity2 combination has potential, upfront, to delay the emergence of resistance to CZ or, after relapse, to overcome resistance. A RP2D has been selected to continue evaluation of these hypotheses in Phase 2 studies of this combination in @entity0 prior to or after progression on CZ.

title: O3.6Combination of XXXX inhibitor onalespib with @entity6 to treat or delay resistance in @entity4 : Preclinical and Clinical Investigations.

answer: @entity5


abstract: UNASSIGNED: Although @entity6 (CZ) has clinical activity in ALK (+) @entity4 ( @entity4 ), relapse is common due to the development of resistance. ALK and components of signalling pathways involved in resistance are client proteins of the chaperone, @entity5 , offering an alternative method for targeting the disease. Onalespib[ @entity2 ]( @entity7 ), a potent 2nd generation @entity5 inhibitor had anti- @entity1 activity in CZ-sensitive and CZ-resistant xenograft models when combined with CZ (Courtin et al). Importantly, when combined upfront with CZ in a CZ-sensitive xenograft model, @entity2 delayed the emergence of resistance observed with CZ monotherapy (Smyth et al.). These preclinical data suggest therapeutic potential for an @entity2 /CZ combination in CZ-sensitive and -resistant disease. This is currently being investigated in a 3-part Phase1/2 randomised @entity4 study. The primary objectives of the Phase 1 part of the clinical study were the safety and tolerability of CZ and @entity2 and selection of the recommended phase 2 dose (RP2D) of @entity2 . A rolling six design was used to determine the maxiumum tolerated dose (MTD)/RP2D of the combination. @entity0 received 250 mg BID oral CZ and IV @entity2 weekly for 3 of 4 weeks of a 28 day cycle (dosing cohorts 150, 180 or 220 mg/m(2)). In Part A, 32 @entity0 , who had prior CZ treatment, were treated with the combination in 3 dosing cohorts. @entity2 was escalated up to 220 mg/m(2) without DLTs and the combination was well tolerated ( @entity3 was the only @entity2 -related AE >=  Grade 3 in > 5% of @entity0 ). The mean number of @entity2 cycles was 4.2 (range 1-11+). @entity2 exposures were similar to previous studies and CZ exposures were unaffected when co-administered with @entity2 . Of 25 evaluable @entity0 , there were 4 PR and over 50% of subjects had a decrease in @entity1 size. CZ/ @entity2 doses of 250 mg BID/220 mg/m(2) were selected as the combination RP2D (Besse et al.). Preclinical data suggest that a CZ/ @entity2 combination has potential, upfront, to delay the emergence of resistance to CZ or, after relapse, to overcome resistance. A RP2D has been selected to continue evaluation of these hypotheses in Phase 2 studies of this combination in @entity0 prior to or after progression on CZ.

title: O3.6Combination of @entity5 inhibitor onalespib with @entity6 to treat or delay resistance in XXXX : Preclinical and Clinical Investigations.

answer: @entity4


abstract: BACKGROUND: @entity10 is a novel broad-spectrum anticancer agent that triply inhibits DNA methyltransferases (DNA MTases), Histone Deacetylases (HDAC), and @entity4 Demethylases. In the first-in- @entity0 , Phase I trial, 5/5 @entity0 who progressed on @entity10 treatment were resensitized to previously refractory @entity8 therapy, hinting at a generalized resensitization effect. A randomized open-label multi-part, multi-center phase II trial of @entity10 versus @entity9 (ROCKET) is underway to explore the resensitization and/or 'episensitization' potential in @entity8 refractory @entity1 and its impact on overall survival. METHODS: @entity0 with @entity8 -refractory metastatic @entity2 with an ECOG PS 0-1 who progressed on @entity6 -, and @entity8 -based regimens with or without bevacizumab, cetuximab or panitumumab are randomized 2:1 to receive @entity10 16.5 mg/m(2) IV 1x/week or @entity9 160 mg orally 21 of 28 days until progression or unacceptable @entity3 followed by treatment with refractory @entity8 -based therapies. RESULTS: To date, 23 @entity0 have been randomized with 10 @entity0 evaluable for resensitization. Post @entity10 @entity0 demonstrated marked decreases in CEA in all 6 @entity0 as compared to 4 @entity0 receiving @entity9 who were too systemically unwell to proceed to subsequent treatment. Progression free survival (ongoing) for @entity10 + @entity8 is 5.9 months compared 0.92 months on @entity9 + @entity8 . Combined Disease Control Rate (SD + PR) for the combination of @entity10 and reintroduction of @entity8 based therapy is currently 100%, whereas no @entity0 to date randomized to the @entity9 arm have been able to start @entity8 based therapy secondary to decreasing performance status. CONCLUSIONS: Early results in the ROCKET study suggest that @entity10 -mediated resensitization to previously refractory therapies may have a generalized effect, independent of @entity7 or @entity5 status. These early results are intriguing and may be a major advancement in epigenetic therapy. @entity10 is a novel pan-epigenetic inhibitor that may potentially offer improved QOL and overall survival over currently approved therapy in the chemotherapy refractory @entity2 .

title: O3.8Early Results: "ROCKET" a phase II Study of @entity10 , a novel triple epigenetic inhibitor, Resensitization to @entity8 in XXXX .

answer: @entity2


abstract: BACKGROUND: @entity10 is a novel broad-spectrum anticancer agent that triply inhibits DNA methyltransferases (DNA MTases), Histone Deacetylases (HDAC), and @entity4 Demethylases. In the first-in- @entity0 , Phase I trial, 5/5 @entity0 who progressed on @entity10 treatment were resensitized to previously refractory @entity8 therapy, hinting at a generalized resensitization effect. A randomized open-label multi-part, multi-center phase II trial of @entity10 versus @entity9 (ROCKET) is underway to explore the resensitization and/or 'episensitization' potential in @entity8 refractory @entity1 and its impact on overall survival. METHODS: @entity0 with @entity8 -refractory metastatic @entity2 with an ECOG PS 0-1 who progressed on @entity6 -, and @entity8 -based regimens with or without bevacizumab, cetuximab or panitumumab are randomized 2:1 to receive @entity10 16.5 mg/m(2) IV 1x/week or @entity9 160 mg orally 21 of 28 days until progression or unacceptable @entity3 followed by treatment with refractory @entity8 -based therapies. RESULTS: To date, 23 @entity0 have been randomized with 10 @entity0 evaluable for resensitization. Post @entity10 @entity0 demonstrated marked decreases in CEA in all 6 @entity0 as compared to 4 @entity0 receiving @entity9 who were too systemically unwell to proceed to subsequent treatment. Progression free survival (ongoing) for @entity10 + @entity8 is 5.9 months compared 0.92 months on @entity9 + @entity8 . Combined Disease Control Rate (SD + PR) for the combination of @entity10 and reintroduction of @entity8 based therapy is currently 100%, whereas no @entity0 to date randomized to the @entity9 arm have been able to start @entity8 based therapy secondary to decreasing performance status. CONCLUSIONS: Early results in the ROCKET study suggest that @entity10 -mediated resensitization to previously refractory therapies may have a generalized effect, independent of @entity7 or @entity5 status. These early results are intriguing and may be a major advancement in epigenetic therapy. @entity10 is a novel pan-epigenetic inhibitor that may potentially offer improved QOL and overall survival over currently approved therapy in the chemotherapy refractory @entity2 .

title: O3.8Early Results: "ROCKET" a phase II Study of XXXX , a novel triple epigenetic inhibitor, Resensitization to @entity8 in @entity2 .

answer: @entity10


abstract: BACKGROUND: @entity10 is a novel broad-spectrum anticancer agent that triply inhibits DNA methyltransferases (DNA MTases), Histone Deacetylases (HDAC), and @entity4 Demethylases. In the first-in- @entity0 , Phase I trial, 5/5 @entity0 who progressed on @entity10 treatment were resensitized to previously refractory @entity8 therapy, hinting at a generalized resensitization effect. A randomized open-label multi-part, multi-center phase II trial of @entity10 versus @entity9 (ROCKET) is underway to explore the resensitization and/or 'episensitization' potential in @entity8 refractory @entity1 and its impact on overall survival. METHODS: @entity0 with @entity8 -refractory metastatic @entity2 with an ECOG PS 0-1 who progressed on @entity6 -, and @entity8 -based regimens with or without bevacizumab, cetuximab or panitumumab are randomized 2:1 to receive @entity10 16.5 mg/m(2) IV 1x/week or @entity9 160 mg orally 21 of 28 days until progression or unacceptable @entity3 followed by treatment with refractory @entity8 -based therapies. RESULTS: To date, 23 @entity0 have been randomized with 10 @entity0 evaluable for resensitization. Post @entity10 @entity0 demonstrated marked decreases in CEA in all 6 @entity0 as compared to 4 @entity0 receiving @entity9 who were too systemically unwell to proceed to subsequent treatment. Progression free survival (ongoing) for @entity10 + @entity8 is 5.9 months compared 0.92 months on @entity9 + @entity8 . Combined Disease Control Rate (SD + PR) for the combination of @entity10 and reintroduction of @entity8 based therapy is currently 100%, whereas no @entity0 to date randomized to the @entity9 arm have been able to start @entity8 based therapy secondary to decreasing performance status. CONCLUSIONS: Early results in the ROCKET study suggest that @entity10 -mediated resensitization to previously refractory therapies may have a generalized effect, independent of @entity7 or @entity5 status. These early results are intriguing and may be a major advancement in epigenetic therapy. @entity10 is a novel pan-epigenetic inhibitor that may potentially offer improved QOL and overall survival over currently approved therapy in the chemotherapy refractory @entity2 .

title: O3.8Early Results: "ROCKET" a phase II Study of @entity10 , a novel triple epigenetic inhibitor, Resensitization to XXXX in @entity2 .

answer: @entity8


abstract: UNASSIGNED: A biological complex organism is involuntarily guided from all sides by measure and regulation systems. The @entity0 being is such a complex organism. Many cyclical processes are simultaneously at work, making it unclear how and why which process takes place at which moment. Noticeable examples are the 28-day menstrual cycle and the 40-week pregnancy. The time of activation in the middle of the menstrual is fairly clear. Hormonal changes also occur in this period. Why the hormonal changes occur, and what their relationship is with the activation of the processes is unclear. That is also the case during pregnancies. What is it that determines that a pregnancy should last an average of 40weeks? What causes the changes in a complicated pregnancy? What are those changes? Prostaglandin concentrations have been found to have some relationship with these changes, but the activation of these changes and how to examine them is unknown. Using an example from practical experience, this article illustrates what Horrobin and Manku already reported in 1977, namely, the properties of @entity4 and 6-keto pgF1a: reversal effect with elevated concentration. The properties described is exceptionally suitable for the time of activation in a biochemically regulated measure and regulation system. These properties can help explain the occurrence of physiological cycles. The known electronic saw-tooth wave has a biochemical analogue with this. This paper describes the presumed relationship between hormones and the accompanying @entity2 with the hormone effects based on what is known regarding their concentrations progress. This relationship reveals the practical consequences of the experimentally found sensitivity of biochemical effects with regard to the accompanying @entity2 . This paper shows how the theoretical relationship between effects of @entity3 and progestagens result in a curve that comprise observable aspects of the Basal Body Temperature Curve. The modulating and activating @entity2 also affect local changes in blood circulation. These changes are visible on specific sites on the abdominal skin via viscerocutaneous reflex pathways. Changes in blood circulation at specific areas of the skin can be representative of @entity1 . @entity1 that also frequently arises during activation processes. These changes can be seen and measured with non-contactual infrared thermography on the cutaneous surface, and moments of activation and @entity1 can be determined.

title: A theoretical model of biochemical control engineering based on the relation between XXXX /progestagens and @entity2 .

answer: @entity3


abstract: UNASSIGNED: A biological complex organism is involuntarily guided from all sides by measure and regulation systems. The @entity0 being is such a complex organism. Many cyclical processes are simultaneously at work, making it unclear how and why which process takes place at which moment. Noticeable examples are the 28-day menstrual cycle and the 40-week pregnancy. The time of activation in the middle of the menstrual is fairly clear. Hormonal changes also occur in this period. Why the hormonal changes occur, and what their relationship is with the activation of the processes is unclear. That is also the case during pregnancies. What is it that determines that a pregnancy should last an average of 40weeks? What causes the changes in a complicated pregnancy? What are those changes? Prostaglandin concentrations have been found to have some relationship with these changes, but the activation of these changes and how to examine them is unknown. Using an example from practical experience, this article illustrates what Horrobin and Manku already reported in 1977, namely, the properties of @entity4 and 6-keto pgF1a: reversal effect with elevated concentration. The properties described is exceptionally suitable for the time of activation in a biochemically regulated measure and regulation system. These properties can help explain the occurrence of physiological cycles. The known electronic saw-tooth wave has a biochemical analogue with this. This paper describes the presumed relationship between hormones and the accompanying @entity2 with the hormone effects based on what is known regarding their concentrations progress. This relationship reveals the practical consequences of the experimentally found sensitivity of biochemical effects with regard to the accompanying @entity2 . This paper shows how the theoretical relationship between effects of @entity3 and progestagens result in a curve that comprise observable aspects of the Basal Body Temperature Curve. The modulating and activating @entity2 also affect local changes in blood circulation. These changes are visible on specific sites on the abdominal skin via viscerocutaneous reflex pathways. Changes in blood circulation at specific areas of the skin can be representative of @entity1 . @entity1 that also frequently arises during activation processes. These changes can be seen and measured with non-contactual infrared thermography on the cutaneous surface, and moments of activation and @entity1 can be determined.

title: A theoretical model of biochemical control engineering based on the relation between @entity3 /progestagens and XXXX .

answer: @entity2


abstract: We examine the effect of solvent on the charging mechanisms of a macromolecule in a droplet by using molecular dynamics simulations. The droplet contains excess charge that is carried by @entity3 ions. To investigate the principles of the charging mechanisms of a macromolecule in a droplet, we simulate aqueous and @entity2 droplets that contain a @entity0 ( @entity1 ) molecule. We find that the solvent plays a critical role in the charging mechanism and in the manner that the sodiated @entity1 emerges from a droplet. In the aqueous droplets, the sodiated @entity1 is released from the droplet while it is being charged at a droplet charge state below the Rayleigh limit. The charging of @entity1 occurs on the surface of the droplet. In contrast to the aqueous droplets, in the @entity2 droplet, the sodiated @entity1 resides in the interior of the droplet and it may become charged at any location in the droplet, interior or surface. The sodiated @entity1 emerges from the droplet by drying-out of the solvent. Even though these two mechanisms appear to be phenomenologically similar to the widely accepted ion-evaporation and charge-residue mechanisms, they have fundamental differences from those. An integral part of the mechanism that the macromolecular ions emerge from droplets is the droplet morphology. Droplet morphologies give rise to different solvation interactions between the solvent and the macromolecule. In the water-sodiated @entity1 system, we find the extrusion of the @entity1 morphology, while in @entity2 -sodiated droplet, we find the "pearl-on-the-necklace" morphology and the extrusion of the sodiated @entity1 in the last stage of the desolvation process. These findings provide insight into the mechanisms that macromolecules acquire their charge in droplets produced in electrospray ionization experiments.

title: Effect of solvent on the charging mechanisms of XXXX in droplets.

answer: @entity0


abstract: UNASSIGNED: @entity1 increases the incidence of @entity4 significantly. Various hereditary and acquired factors are known for @entity5 . The hereditary factors are two common genetic autosomal mutations including factor V leidan mutation and @entity3 gene mutation. A descriptive- analytical design was conducted on 60 @entity0 with @entity5 who met the inclusion criteria. Two groups with hereditary and acquired risk factors for @entity5 (group A, B, each 30 @entity0 ) were evaluated. All the @entity0 of two groups were evaluated in terms of emboli associated with hereditary and acquired risk factors. Association of @entity5 risk factors' with @entity2 were studied at the beginning of the study and six months after the treatment then the results of two groups were compared. Among @entity0 , 31 (56.4%) were @entity0 .   The mean age of the @entity0 was 44.4  14 years, ranging between 23-75 years. Significant association was observed between the stability of the blood clot in pulmonary vessel, six months after the treatment with genetic risk factors (P=0.03). However, no significant association was between @entity2 and hereditary and acquired risk factors (P=0.24). Based on the significant association between the hereditary risk factors and @entity6 , by taking special prevention and therapy measurements (e.g. genetic engineering), some pulmonary and mortality complications can be prevented and the @entity0 himself and health care system would benefit from this issue.

title: Association of Chronic XXXX with Hereditary and Acquired Risk Factors for @entity5 .

answer: @entity2