abstract: AIM: @entity3 could be considered an expression of atypical @entity1 . The recent neuropathological findings in BMS may suggest the need for alternative therapies. This paper aims to evaluate if systemic @entity2 could be used for BMS the- rapy. METHODS: Eighty-four BMS @entity0 (19 males and 63 females, aged 36 to 74 years, mean 54.6) were referred to the Oral Medicine and Oral Pathology Department, Dental University Institute, Milan-Bicocca University. They were divided in 2 groups: 1(st) Group: the first group (42 @entity0 ) received 3 capsules of @entity2 (50 mg of powder of red pepper with 0,25% of @entity2 ) a day for one month. 2(nd) Group: the control group (42 @entity0 ) received 3 capsules of placebo (empty capsules) a day for one month. The intensity of @entity1 was measured on the visuo-analogical scale VAS. T test of Student was applied to analyse results of VAS. P values of less than 0.05 were interpreted as significant, and the level in confidence intervals was 95%. RESULTS: Significant differences were noted between the two groups at the end of our study (p<0.05). No important side effects were reported. CONCLUSION: Systemic @entity2 could be considered a successful therapeutical approach for BMS @entity0 .

title: [Preliminary protocol for systemic administration of XXXX for the treatment of the @entity3 ].

answer: @entity2


abstract: AIM: @entity3 could be considered an expression of atypical @entity1 . The recent neuropathological findings in BMS may suggest the need for alternative therapies. This paper aims to evaluate if systemic @entity2 could be used for BMS the- rapy. METHODS: Eighty-four BMS @entity0 (19 males and 63 females, aged 36 to 74 years, mean 54.6) were referred to the Oral Medicine and Oral Pathology Department, Dental University Institute, Milan-Bicocca University. They were divided in 2 groups: 1(st) Group: the first group (42 @entity0 ) received 3 capsules of @entity2 (50 mg of powder of red pepper with 0,25% of @entity2 ) a day for one month. 2(nd) Group: the control group (42 @entity0 ) received 3 capsules of placebo (empty capsules) a day for one month. The intensity of @entity1 was measured on the visuo-analogical scale VAS. T test of Student was applied to analyse results of VAS. P values of less than 0.05 were interpreted as significant, and the level in confidence intervals was 95%. RESULTS: Significant differences were noted between the two groups at the end of our study (p<0.05). No important side effects were reported. CONCLUSION: Systemic @entity2 could be considered a successful therapeutical approach for BMS @entity0 .

title: [Preliminary protocol for systemic administration of @entity2 for the treatment of the XXXX ].

answer: @entity3


abstract: Cytogenetic and molecular genetic studies have implicated many chromosomal aberrations in the pathogenesis of @entity1 . Deletions on 3p and 9p are presently the primary target for positional cloning of putative @entity2 suppressor genes. We have recently reported frequent loss of heterozygosity in three separate regions (HRAS, D11S12, D11S16) on 11p in freshly resected @entity1 specimens. Here we report cytogenetic and molecular genetic analyses of 26 permanently growing @entity0 @entity1 cell lines. Deletions indicating regions which may harbor potential @entity2 suppressor genes were found in 5/9 cell lines on 2p, 5/9 on 2q, 6/9 on 3p, 7/9 on 3q, 5/9 on 6q, 3/9 on 9p, 5/9 on 11p, and 6/9 on 13q. Reduction to hemizygosity or a statistically significant increase in the frequency of homozygosity on 11p was found for all markers investigated except for @entity5 ( @entity6 ). Eight of twenty-six (31%) cell lines were hemizygous for D11S12 and 9/26 (35%) for D11S16. Seventeen of eighteen (94%) cell lines were homozygous for @entity3 (expected homozygosity, 53%), 15/15 (100%) for @entity4 (expected homozygosity, 55%), and 16/18 (89%) for CAT (expected homozygosity, 50%). These results confirm the notion that 11p harbors several putative @entity2 suppressor genes which may become inactivated at different stages of @entity2 development and progression. They also provide a basis for selecting cell lines for genetic complementation specifically targeted at the regions described.

title: Multiple chromosomal aberrations and 11p allelotyping in XXXX cell lines.

answer: @entity1


abstract: OBJECTIVE: In the interventional treatment of @entity1 , the thalamic ventral intermediate nucleus ( @entity2 ) and the subthalamic nucleus (STN) are the most relevant electrode targets for deep brain stimulation (DBS). This study tested the value of somatosensory evoked potentials (SEP) for the functional identification of @entity2 and STN. METHODS: Median nerve SEP were recorded from the final stimulation electrodes targeted at STN and @entity2 . Throughout the stereotactic procedure SEP were recorded during short electrode stops above STN/ @entity2 and within the presumed target areas. After digital filtering, high and low frequency SEP components were analysed separately to parameterise both the 1000 Hz SEP burst and low frequency (<100 Hz) components. RESULTS: SEP recorded in the @entity2 target region could unequivocally be distinguished from SEP recorded in STN. The 1000 Hz burst signal was significantly larger in @entity2 than in STN without any overlap of amplitude values. In the low frequency band, a primary high amplitude negativity was obtained in @entity2 , contrasting with a low amplitude positivity in STN. SEP waveshapes in recordings above target positions resembled SEP obtained in STN. When entering @entity2 , a sharp amplitude increase was observed over a few millimetres only. CONCLUSIONS: Based on SEP criteria, the @entity2 target but not the STN region can be identified by typical SEP configuration changes, when penetrating the target zone. The approach is independent of the @entity0 's cooperation and vigilance and therefore feasible in general anaesthesia. It provides an easy, reliable, and robust tool for the final assessment of electrode positions at the last instance during electrode implantation when eventual electrode revisions can easily be performed.

title: Identification of target areas for deep brain stimulation in XXXX basal ganglia substructures based on median nerve sensory evoked potential criteria.

answer: @entity0


abstract: The operative treatment of 77 @entity0 with @entity8 of the pararenal aorta (54 juxtarenal and 23 suprarenal) is analyzed. Repair of these complex lesions is formidable because of difficult exposure, @entity1 and @entity4 as a result of proximal @entity5 , and associated @entity1 with @entity1 . Nineteen (25%) @entity0 were normotensive with normal renal function. Sixteen @entity0 (21%) had @entity2 alone and 42 (54%) were @entity2 with @entity1 . There were @entity1 in 22% of @entity0 . Aortic reconstruction involved infrarenal graft in 27 @entity0 (35%), infrarenal graft plus pararenal aortic endarterectomy (TEA) in 26 (34%), and infra- and pararenal aortic graft in 24 (31%). Twenty-two @entity0 (30%) had normal renal arteries and therefore no renal reconstruction. Of the 55 @entity0 who required combined aortic and renal artery repair, 24 required renal artery repair because of involvement of the renal arteries by the @entity6 and 31 because of @entity1 . TEA was the most common technique of renal artery repair (54 of 93 arteries, 58%), followed by reimplantation (18 arteries) and prosthetic graft (13). The perioperative mortality rate was 1.3%. The perioperative morbidity rate was 28% and consisted principally of @entity3 (23%). This was usually transient (44%) and (89%) mild. Renal morbidity was adversely affected by @entity1 status, severity of @entity1 and extent of renal revascularization. Following reconstruction, @entity2 was cured or improved in 77% of @entity0 and @entity1 was cured or improved in 46% and stabilized in an additional 39% of @entity0 . These results show that combined @entity7 repair and renal artery reconstruction can be performed with minimal mortality and an acceptable morbidity. Aggressive intraoperative monitoring is necessary to minimize @entity4 . Careful attention must be paid to the technical details of the reconstruction, especially in minimizing @entity1 , to reduce the subsequent incidence of @entity3 .

title: Management of XXXX .

answer: @entity6


abstract: Reperfusional damage refers to the serious structural, functional, and metabolic derangements commonly observed during restoration of coronary circulation following cardiopulmonary bypass. Damage is believed to result from @entity1 incurred during aortic cross-clamping and unmasked in the recovery period and/or certain metabolic processes activated during postischemic reperfusion. It has been postulated that reperfusional damage can be minimized or eliminated if normal myocardial metabolic parameters can be maintained or restored before the initiation of reperfusion. Studies have tested a variety of @entity6 and administration modes. However, much controversy exists over the different methods. We have tested the hypothesis that improved myocardial protection during cardioplegia can prevent reperfusional damage and investigated the possibility of achieving optimal myocardial protection. Elective @entity5 was induced in isolated perfused @entity0 hearts, under working conditions reported previously. We tested two arresting temperatures (8 degrees C and 28 degrees C), three infusion frequencies (single, double, and multiple dose), and different combinations of cardioplegic additives with demonstrated benefits ( @entity2 , @entity3 , @entity4 , and albumin). Metabolic and hemodynamic functions were used to evaluate the protection of the @entity1 . @entity2 (0.5%) and @entity3 (1 mmol/L) provided clear benefits under all experimental conditions. Double-dose cardioplegia at 8 degrees C also surpassed the single- and multiple-dose groups. When oxygenated cardioplegic solution containing @entity2 and @entity3 was reinfused for 1 minute after 30 minutes of cross-clamping, no measurable changes were detected after @entity1 , as compared with normal hearts. Reperfusional damage was eliminated by this procedure. We concluded that an optimal condition for myocardial preservation during elective @entity5 in our model was established.

title: Prevention of reperfusional damage from XXXX .

answer: @entity1


abstract: The authors present the results of surgical treatment in 165 @entity0 with nontumoral @entity2 , treated during a period of 11 years. The minimum period of follow-up was 1 year. The results in the group of @entity0 treated with a ventriculoatrial (VA) shunt were compared to those obtained in the group with a ventriculoperitoneal (VP) shunt. 45% of @entity0 with VA shunts had one or more revisions, against 51% of @entity0 with VP shunts. However, the incidence of revisions after 6 months from primary insertion was lower in the VP-shunted @entity0 . Most revisions were due to @entity4 : obstruction of the ventricular or abdominal catheter was the commonest finding. Among complications, the most serious was constituted by @entity1 (11% of cases). Most @entity1 occurred at less than 2 months from surgery and were caused mainly by Staphylococci. 31% of infected @entity0 died. Other frequent complications were due to shunt tubing lost in abdomen or in the ventricles and subdural @entity3 . The overall mortality rate in the whole group was 18%, while the shunt-related mortality rate was 10.9%. Complications were more frequent in the VP-shunted @entity0 , but were less than in VA-shunted @entity0 and accounted for a lower mortality rate. Complications and mortality rate were prevalent in the @entity0 presenting congenital communicating @entity2 or myelomeningocele. It is concluded that VP shunt is preferable to VA shunt in the treatment of infantile @entity2 .

title: Results of treatment with XXXX in infantile nontumoral @entity2 .

answer: @entity4


abstract: The authors present the results of surgical treatment in 165 @entity0 with nontumoral @entity2 , treated during a period of 11 years. The minimum period of follow-up was 1 year. The results in the group of @entity0 treated with a ventriculoatrial (VA) shunt were compared to those obtained in the group with a ventriculoperitoneal (VP) shunt. 45% of @entity0 with VA shunts had one or more revisions, against 51% of @entity0 with VP shunts. However, the incidence of revisions after 6 months from primary insertion was lower in the VP-shunted @entity0 . Most revisions were due to @entity4 : obstruction of the ventricular or abdominal catheter was the commonest finding. Among complications, the most serious was constituted by @entity1 (11% of cases). Most @entity1 occurred at less than 2 months from surgery and were caused mainly by Staphylococci. 31% of infected @entity0 died. Other frequent complications were due to shunt tubing lost in abdomen or in the ventricles and subdural @entity3 . The overall mortality rate in the whole group was 18%, while the shunt-related mortality rate was 10.9%. Complications were more frequent in the VP-shunted @entity0 , but were less than in VA-shunted @entity0 and accounted for a lower mortality rate. Complications and mortality rate were prevalent in the @entity0 presenting congenital communicating @entity2 or myelomeningocele. It is concluded that VP shunt is preferable to VA shunt in the treatment of infantile @entity2 .

title: Results of treatment with @entity4 in infantile nontumoral XXXX .

answer: @entity2


abstract: 1. @entity4 to a temperature of 30 degrees C was induced in both shivering and non-shivering groups of @entity2 . 2. There was a sustained increase in @entity0 consumption in the @entity2 allowed to shiver and this was up to 300% greater than the @entity0 consumption in the relaxed @entity2 . 3. The increased tissue requirement for @entity0 was met both by @entity5 and increased @entity0 extraction from haemoglobin. 4. @entity0 utilization remained adequate in @entity4 , as shown by the absence of @entity3 . 5. Heart rate fell during cooling and @entity1 volume increased to meet the increased @entity0 demands associated with shivering during the induction of @entity4 .

title: Cooling responses in shivering and non-shivering @entity2 during induced XXXX .

answer: @entity4


abstract: 1. @entity4 to a temperature of 30 degrees C was induced in both shivering and non-shivering groups of @entity2 . 2. There was a sustained increase in @entity0 consumption in the @entity2 allowed to shiver and this was up to 300% greater than the @entity0 consumption in the relaxed @entity2 . 3. The increased tissue requirement for @entity0 was met both by @entity5 and increased @entity0 extraction from haemoglobin. 4. @entity0 utilization remained adequate in @entity4 , as shown by the absence of @entity3 . 5. Heart rate fell during cooling and @entity1 volume increased to meet the increased @entity0 demands associated with shivering during the induction of @entity4 .

title: Cooling responses in shivering and non-shivering XXXX during induced @entity4 .

answer: @entity2


abstract: There is evidence that the @entity2 is associated with rectal prolapse either overt or internal. The anterior rectal wall is affected in most cases and a modified abdominal rectopexy has been used with the aim of supporting both the anterior and posterior aspects of the rectum. Fourteen @entity0 aged 19-70 years (mean 34.2 years) in whom conservative treatment has failed, have been treated by anteroposterior rectopexy. Tenesmus, @entity1 and the passage of mucus have been abolished or greatly improved in 12, 14 and 13 @entity0 respectively. The number of attempts to defaecate per 24 h has fallen from 8.7 +/- 1.4(s.e.m.) pre-operatively to 3.4 +/- 1.0(s.e.m.) postoperatively (P less than 0.05) and the time spent in the lavatory has been reduced from 146 +/- 18(s.e.m.) min to 15 +/- 3(s.e.m.) min. Two @entity0 have developed severe @entity3 postoperatively and two others have had persistent or recurrent tenesmus. Combined anteroposterior rectopexy has improved 12 out of 14 @entity0 with the solitary @entity2 without external rectal prolapse when assessed at 2-48 months postoperatively.

title: Anteroposterior rectopexy in the treatment of XXXX without overt rectal prolapse.

answer: @entity2


abstract: PURPOSE: The treatment of @entity5 remains a therapeutic challenge, with median survival rates of about 12 months and local failure rates of up to 80%. Our institution recently published results showing that extrapleural pneumonectomy (EPP) followed by hemithoracic radiation yielded excellent local control. This paper reports our technique for high-dose hemithoracic radiation after EPP. METHODS: Between 1990 and 2001, 35 @entity0 with @entity5 were treated with EPP followed by hemithoracic radiation therapy (median dose: 54 Gy, range: 45-54 Gy) at Memorial Sloan-Kettering Cancer Center. EPP was defined as en bloc resection of the entire pleura, lung, and diaphragm with or without resection of the pericardium. The radiation therapy target volume was the entire hemithorax, including the pleural folds and the thoracotomy and chest tube incision sites. @entity0 were treated with a total dose of 5400 cGy delivered in 30 fractions of 180 cGy. Radiation therapy was well tolerated, and @entity2 data are described. RESULTS: Of the 35 @entity0 analyzed, 29 @entity0 were male, and 18 had right-sided @entity1 . Twenty-six had epithelioid histologies. UICC stage was I in 4, II in 11, III in 19, and IV in 1 @entity0 . As shown by axial and sagittal isodose distributions, we were able to deliver adequate doses to the target volume while limiting dose to critical structures such as heart, spinal cord, liver, and stomach. The most common @entity2 were RTOG Grades 1 and 2 @entity3 and @entity4 , as well as lung, esophageal, and @entity2 . CONCLUSION: Extrapleural pneumonectomy followed by high-dose hemithoracic radiation therapy is a feasible treatment regimen that is well tolerated for @entity0 with @entity5 . We have demonstrated adequate dose distributions, using a combined photon and electron technique with blocking of critical normal structures.

title: Hemithoracic radiation after extrapleural pneumonectomy for XXXX .

answer: @entity5


abstract: To explore the pathophysiology of the @entity3 caused by @entity4 in the newborn @entity1 , the effect of acute @entity4 on fibrinogen disappearance rate was studied in 38 puppies (3-14 days). All pups received an exchange transfusion removing 65 ml/kg of blood and transfusing 85 ml/kg of either whole blood (control, resulting hematocrit = 37), or packed red blood cells ( @entity4 , resulting hematocrit = 68). @entity3 was found in 15 of 19 polycythemic and four of 19 control pups (p less than 0.01). 125I fibrinogen and Evan's blue (an albumin marker) were injected 2 h after transfusion and the concentration of clottable labeled fibrinogen and albumin tracer were measured at 1/2 and 2 h after injection. The fraction of the tracer that disappeared over the 1 1/2-h period was calculated. In the polycythemic group 45 +/- 18 SD% of the clottable fibrinogen disappeared versus only 28 +/- 15% in the control group (p less than 0.01). In the polycythemic group 36 +/- 21% of the albumin tracer disappeared versus 31 +/- 12% in the control group (NS). Thus @entity4 in the newborn @entity1 is associated with an @entity0 of clottable fibrinogen not associated with a general increase in protein disappearance rate. Thus an @entity2 is evident in the polycythemic animals. Whether this @entity2 is the cause of the @entity3 or is secondary to the @entity3 seen in this animal model cannot be determined from this experiment.

title: Acute XXXX increases the disappearance rate of clottable fibrinogen in the newborn @entity1 .

answer: @entity4


abstract: To explore the pathophysiology of the @entity3 caused by @entity4 in the newborn @entity1 , the effect of acute @entity4 on fibrinogen disappearance rate was studied in 38 puppies (3-14 days). All pups received an exchange transfusion removing 65 ml/kg of blood and transfusing 85 ml/kg of either whole blood (control, resulting hematocrit = 37), or packed red blood cells ( @entity4 , resulting hematocrit = 68). @entity3 was found in 15 of 19 polycythemic and four of 19 control pups (p less than 0.01). 125I fibrinogen and Evan's blue (an albumin marker) were injected 2 h after transfusion and the concentration of clottable labeled fibrinogen and albumin tracer were measured at 1/2 and 2 h after injection. The fraction of the tracer that disappeared over the 1 1/2-h period was calculated. In the polycythemic group 45 +/- 18 SD% of the clottable fibrinogen disappeared versus only 28 +/- 15% in the control group (p less than 0.01). In the polycythemic group 36 +/- 21% of the albumin tracer disappeared versus 31 +/- 12% in the control group (NS). Thus @entity4 in the newborn @entity1 is associated with an @entity0 of clottable fibrinogen not associated with a general increase in protein disappearance rate. Thus an @entity2 is evident in the polycythemic animals. Whether this @entity2 is the cause of the @entity3 or is secondary to the @entity3 seen in this animal model cannot be determined from this experiment.

title: Acute @entity4 increases the disappearance rate of clottable fibrinogen in the newborn XXXX .

answer: @entity1


abstract: PURPOSE: Chemoradiation based on @entity3 , most commonly weekly, is the standard treatment of locally advanced cervical @entity1 ; however, the nephrotoxic potential and the requirement for hydration of @entity3 somewhat restrains its use. The objective of this study was to determine the recommended dose of @entity7 when administered weekly during pelvic @entity4 ( @entity4 ). METHODS AND MATERIALS: Twenty-four histologically proven, International Federation of Gynecology and Obstetrics Stage IIIB @entity0 were treated with standard pelvic @entity4 concurrently with six weekly applications of @entity7 at the following dose levels: 100 mg/m(2), 116 mg/m(2), 133 mg/m(2), and 150 mg/m(2). Six @entity0 per level were treated. Acute @entity2 was assessed according to the Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria. The recommended dose was defined as the one that was one level below the level at which dose-limiting @entity2 was present in more than one-third of @entity0 . RESULTS: Between September 2001 and July 2002, 24 @entity0 were accrued. All but two completed external beam radiotherapy and intracavitary treatment. The treatment was well tolerated. The median number of weekly applications of @entity7 was six, and the mean dose to points A and B was 85.6 Gy (range 75.2-91.6) and 62.9 Gy (range 58.2-74.6), respectively. @entity4 was delivered within 41.7 days (range 33-70). Dose-limiting @entity2 ( @entity6 and/or @entity5 ) was present in 50% of @entity0 treated at the higher dose level (150 mg/m(2)). At the recommended dose of 133 mg/m(2), 33% of @entity0 presented with Grade 3 @entity6 . At treatment completion, 75% of @entity0 had a complete clinical response. CONCLUSION: @entity7 at 133 mg/m(2), weekly for 6 weeks, is a well tolerated and effective radiosensitizer in cervical @entity1 @entity0 .

title: A phase I study of XXXX concurrent with @entity4 in FIGO stage IIIB cervix uteri carcinoma.

answer: @entity7


abstract: PURPOSE: Chemoradiation based on @entity3 , most commonly weekly, is the standard treatment of locally advanced cervical @entity1 ; however, the nephrotoxic potential and the requirement for hydration of @entity3 somewhat restrains its use. The objective of this study was to determine the recommended dose of @entity7 when administered weekly during pelvic @entity4 ( @entity4 ). METHODS AND MATERIALS: Twenty-four histologically proven, International Federation of Gynecology and Obstetrics Stage IIIB @entity0 were treated with standard pelvic @entity4 concurrently with six weekly applications of @entity7 at the following dose levels: 100 mg/m(2), 116 mg/m(2), 133 mg/m(2), and 150 mg/m(2). Six @entity0 per level were treated. Acute @entity2 was assessed according to the Radiation Therapy Oncology Group Acute Radiation Morbidity Scoring Criteria. The recommended dose was defined as the one that was one level below the level at which dose-limiting @entity2 was present in more than one-third of @entity0 . RESULTS: Between September 2001 and July 2002, 24 @entity0 were accrued. All but two completed external beam radiotherapy and intracavitary treatment. The treatment was well tolerated. The median number of weekly applications of @entity7 was six, and the mean dose to points A and B was 85.6 Gy (range 75.2-91.6) and 62.9 Gy (range 58.2-74.6), respectively. @entity4 was delivered within 41.7 days (range 33-70). Dose-limiting @entity2 ( @entity6 and/or @entity5 ) was present in 50% of @entity0 treated at the higher dose level (150 mg/m(2)). At the recommended dose of 133 mg/m(2), 33% of @entity0 presented with Grade 3 @entity6 . At treatment completion, 75% of @entity0 had a complete clinical response. CONCLUSION: @entity7 at 133 mg/m(2), weekly for 6 weeks, is a well tolerated and effective radiosensitizer in cervical @entity1 @entity0 .

title: A phase I study of @entity7 concurrent with XXXX in FIGO stage IIIB cervix uteri carcinoma.

answer: @entity4


abstract: Although nonoperative management is the standard initial treatment in @entity0 with @entity1 , this therapeutic option has been exercised infrequently in adults. Over the past two years we have hospitalized and observed 11 hemodynamically stable adults with @entity1 and no other significant injury. Ten @entity0 sustained @entity1 localized to the left upper quadrant, and one @entity0 was stabbed in the left flank. Eight @entity0 were normotensive on hospital arrival, while three had an initial systolic blood pressure of 90 to 98 mm Hg. All @entity0 remained normotensive after receiving 2 liters of crystalloid fluid IV. Nine @entity0 had an initial hemoglobin level of 11.1 to 14.0 gm/dl, and two a level of less than 10 gm/dl. Liver-spleen scan done in ten @entity0 yielded true-positive results in eight, false-positive results in one, and false-negative results in one. In the 11th @entity0 , a celiac arteriogram showed a @entity2 . Three @entity0 had laparotomy 27 to 43 hours after hospitalization, owing to a decreasing hemoglobin concentration; one required partial splenectomy. Eight @entity0 were successfully managed nonoperatively; only one required blood transfusion, and all tolerated oral alimentation by the second hospital day. All @entity0 were discharged by the 12th hospital day. Nonoperative management can be successfully applied to adults with isolated @entity1 .

title: XXXX in adults: selective nonoperative management.

answer: @entity1


abstract: Soft @entity3 continue to present problems with both local control of disease and @entity2 from distant metastases after accepted surgical therapy. Multimodality management has been established in the literature to be superior to traditional therapy of wide excision or amputation. The results of the treatment of 64 @entity0 at Oregon Health Sciences University using regional hyperthermic perfusion with @entity9 mustard and @entity8 , wide local excision and external radiation therapy are reviewed. Histologic tumor types included: 19 @entity6 , 14 @entity4 , eight @entity5 , five @entity7 , four @entity1 and 14 other @entity3 . Minimum follow-up study has been 24 months and the mean follow-up time is more than five years. One-third of the @entity0 presented with local recurrent disease after unsuccessful primary treatment. Over-all local recurrence for all @entity0 treated by a combination of the aforementioned modalities was 3.4 per cent at two years and 11.1 per cent at five years. The over-all survival rate for all @entity0 was 88 per cent at two years and 67 per cent at five years compared with a published over-all five year survival rate of 41 per cent. @entity0 with @entity4 had both two and five year local recurrence rates of 7.7 per cent and survival rates at two and five years of 79 and 63 per cent, respectively. This is compared with a previously published over-all five year survival rate with @entity4 of 46 per cent. The results with the treatment of @entity6 were also superior to the published literature. Not only are the treatment results with regional hyperthermic perfusions excellent for both primary and locally recurrent @entity3 , but limbs previously considered unsalvagable can be spared.

title: Improved survival for soft tissue XXXX of the extremities by regional hyperthermic perfusion, local excision and radiation therapy.

answer: @entity3


abstract: D-Dimer measurement is a promising tool in the exclusion of @entity1 . New d-dimer assays have been introduced, but need clinical validation. Our objective was to evaluate the clinical usefulness of four relatively new d-dimer assays and a classical ELISA in outpatients suspected for @entity3 . In 537 @entity0 , @entity0 in a large prospective management study using a clinical probability score and a d-dimer measurement (Tina-quant), additional samples were taken for d-dimer measurement using the Asserachrom ELISA, the VIDAS New, the STA-LIA and the Miniquant assay. Performances of each test were calculated using clinical data during a 3-month follow-up. @entity2 was detected in 224 @entity0 (42%). The area under the ROC curve was significantly higher for the Tina-quant as compared to the other assays. Using standard cut-off values, sensitivity, negative predictive value (NPV) and specificity of the Asserachrom were 97, 94 and 33%, respectively. For the VIDAS New, values were 100, 96 and 8%, respectively. The Tina-quant showed values of 99, 98 and 41%, respectively, and the STA-LIA 98, 95 and 32%. Values for the Miniquant were 95, 94 and 52%. The d-dimer assays in our study all show a high sensitivity and negative predictive value, but none of the assays reached an NPV of > 98% at standard cut-off values. d-Dimer assays with a low specificity still necessitate additional diagnostic tests in the majority of the @entity0 .

title: The usefulness of five D-dimer assays in the exclusion of XXXX .

answer: @entity3


abstract: OBJECTIVE: To examine the relationship between the gene for @entity6 ( @entity6 ) and @entity0 essential @entity1 , because both the acute and systemic induction of @entity6 have been suggested to attenuate vascular tone and blood pressure. METHODS: We screened for sequence variations in @entity6 and conducted an association study, using these polymorphisms, in a large cohort (1998 individuals) representing the general Japanese population. RESULTS We sequenced @entity6 and found a T(-413)A polymorphism in the promoter region. The frequency of @entity1 individuals and the use of antihypertensive drugs were significantly greater in the AA genotype than in other genotypes among @entity0 : 45.5, 34.2, and 35.0% (P = 0.0099) and 23.4, 17.5, and 15.0% (P = 0.038), respectively, for the AA, @entity3 , and TT genotypes, respectively. However, this association was not observed in @entity0 . Multiple logistic analyses indicated that the T(-413)A (AA/TA+TT) polymorphism, age, and body mass index affected the occurrence of @entity1 in @entity0 . The odds ratio of the AA genotype for @entity1 in @entity0 was 1.59 (P = 0.0058; 95% confidence interval 1.14 to 2.20). A luciferase reporter assay indicated that the A allele-promoter had eight-fold greater activity than the T allele promoter (P < 0.01). CONCLUSIONS: The AA genotype of @entity6 is associated with an increased incidence of @entity1 in @entity0 . @entity5 attenuates vasoconstriction by increasing the expression of inducible @entity2 synthase. As @entity4 , which is one of the products of @entity6 , can attenuate @entity2 -induced vasodilatation, a high expression of @entity6 may cause @entity1 , especially in @entity0 .

title: Association of a promoter variant of the haeme oxygenase-1 gene with XXXX in @entity0 .

answer: @entity1


abstract: OBJECTIVE: To examine the relationship between the gene for @entity6 ( @entity6 ) and @entity0 essential @entity1 , because both the acute and systemic induction of @entity6 have been suggested to attenuate vascular tone and blood pressure. METHODS: We screened for sequence variations in @entity6 and conducted an association study, using these polymorphisms, in a large cohort (1998 individuals) representing the general Japanese population. RESULTS We sequenced @entity6 and found a T(-413)A polymorphism in the promoter region. The frequency of @entity1 individuals and the use of antihypertensive drugs were significantly greater in the AA genotype than in other genotypes among @entity0 : 45.5, 34.2, and 35.0% (P = 0.0099) and 23.4, 17.5, and 15.0% (P = 0.038), respectively, for the AA, @entity3 , and TT genotypes, respectively. However, this association was not observed in @entity0 . Multiple logistic analyses indicated that the T(-413)A (AA/TA+TT) polymorphism, age, and body mass index affected the occurrence of @entity1 in @entity0 . The odds ratio of the AA genotype for @entity1 in @entity0 was 1.59 (P = 0.0058; 95% confidence interval 1.14 to 2.20). A luciferase reporter assay indicated that the A allele-promoter had eight-fold greater activity than the T allele promoter (P < 0.01). CONCLUSIONS: The AA genotype of @entity6 is associated with an increased incidence of @entity1 in @entity0 . @entity5 attenuates vasoconstriction by increasing the expression of inducible @entity2 synthase. As @entity4 , which is one of the products of @entity6 , can attenuate @entity2 -induced vasodilatation, a high expression of @entity6 may cause @entity1 , especially in @entity0 .

title: Association of a promoter variant of the haeme oxygenase-1 gene with @entity1 in XXXX .

answer: @entity0


abstract: @entity0 and Best's @entity2 are synonyma. The different namens for this disease rise from its varying clinical manifestation. The age at which it becomes manifest also varies. Our findings in two families with this @entity0 confirm that the macular changes are polymorphous. Nine different characteristic states of vitelliform @entity2 can be distinguished. The vitelliform stage may represent a previtelliform or a resorptive stage. The differential diagnosis between vitelliform disc and vitelliform cyst can only be made unequivocally by @entity1 angiography. If the vitelliform cyst is scarred directly the scar is sharply delineated. A vitelliform stage or a pseudohypopyon stage may develop, especially form larger vitelliform cysts. In such cases the final stage may be a poorly delineated foveal scar. Occassionally, a mixed picture of two stages is observed, e.g., of cystic and scarred states. Exact knowledge of all stages of the disease is of great interest with resepct to differential diagnosis.

title: [The various stages of vitelliform XXXX ].

answer: @entity2


abstract: OBJECTIVE: @entity8 is a well-known complication of surgical procedures performed with the @entity0 placed in the sitting position. Its incidence and intensity were prospectively studied in 90 consecutive @entity0 undergoing a posterior fossa procedure in this position. Various anesthetic agents, with different effects on cerebral hemodynamics, were used. MATERIAL AND METHODS: @entity0 were randomly assigned to one of three groups. In group 1 (n=30), anesthesia was induced and maintained with @entity4 . In group 2 (n=30), anesthesia was induced with thiopental and maintained with @entity7 . In group 3 (n=30), anesthesia was induced with thiopental and maintained with @entity6 and low-dose @entity7 . All @entity0 received a load dose and an infusion of @entity5 . A cerebral computed tomography scan was performed to all @entity0 8 hours after surgery for detecting the presence and location of intracranial air. The size of @entity8 was ascertained using the formula for calculating the volume of a spheroid: v = PI / 6. x. y. z. Preoperative diagnosis, existence of shunted or non-shunted @entity3 , type and duration of the surgical procedure, detection of intraoperative @entity2 , and appearance of new neurological symptoms in the postoperative period, were recorded. RESULTS: All @entity0 included in the study developed postoperative @entity8 . There were no significant differences (P = 0.133) in the estimated volume of intracranial air between the groups (group 1, volume = 38.3 -/+ 35.4 ml; group 2, volume = 48.9 -/+ 36.3 ml; group 3, volume = 31.5 -/+ 28.4 ml). Only two @entity0 in the group 2 manifested symptoms of @entity1 due to the pressure exerted by the intracranial air. CONCLUSIONS: Despite the hypothetical diverse effects of the three anesthetic techniques used in this series on cerebral hemodynamics, our results suggest that none of them has a substantial effect on the amount of intracranial air detected after posterior fossa procedures performed in seated individuals. To the best of our knowledge this is the first report that addresses in a prospective manner the effects of several habitual anesthetic techniques on the development of @entity8 in @entity0 submitted to posterior fossa procedures performed in the sitting position.

title: Anesthetic technique and development of XXXX after posterior fossa surgery in the sitting position.

answer: @entity8


abstract: BACKGROUND: To assess the prevalence and severity of @entity4 in @entity3 @entity0 and to investigate its effects on sleep and quality of life. METHODS: Seventy @entity0 with @entity3 in Trakya University Medical Faculty Dermatology Department and also applied to Neurology Department in the same center and 70 volunteer controls were enrolled in the study. Severity of the @entity4 ( @entity4 ) was determined using International @entity4 Study Group (IRLSSG) criteria among the @entity0 who have been diagnosed with @entity4 based on IRLSSG criteria. The presence of @entity1 in @entity0 was detected using International Classification of @entity2 (ICSD-II) criteria. Additionally, to evaluate the severity of the disease and quality of life, Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) tests were applied to the @entity0 with @entity3 . RESULTS: @entity4 frequency in @entity0 with @entity3 was 28 (40%) compared to the control group 10 (14.2%), and the difference was statistically significant (p<0.001). IRLSSG severity scores were higher in @entity0 with @entity3 who had @entity1 secondary to @entity4 compared to those who did not have @entity1 (p<0.001). The mean values of PASI were 7.54 +/- 6.52 in the presence of @entity1 and 3.27 +/- 2.69 in the absence of @entity1 . The difference was statistically significant (p<0.001). No significant difference was found in DLQI scores between @entity0 with @entity4 and without @entity4 or between @entity0 with and without @entity1 (p>0.05). DISCUSSIONS: @entity4 frequency in @entity0 with @entity3 was significantly higher than in the control group. In addition, we found that @entity4 is more common but @entity4 severity was mildly high in @entity0 with @entity3 relative to controls. However, there was a correlation between the increase in severity of @entity4 with secondary @entity1 @entity0 who were diagnosed with @entity4 . It may be beneficial to consider @entity4 and @entity1 for each @entity0 diagnosed with @entity3 .

title: RESTLESS LEGS SYNDROME AND INSOMNIA FREQUENCY IN XXXX WITH PSORIASIS.

answer: @entity0


abstract: A case of @entity5 which almost completely occluded the internal carotid artery and was diagnosed angiographically by prolonged injection technique was reported. A 62-year-old house-wife was admitted to the Department of Neurosurgery of The Asahi General Hospital, complaining of @entity1 , @entity3 , and @entity8 . Neurological examination revealed left IInd, IIIrd, IVth, and VIth @entity2 . Films and laminagrams of the skull demonstrated the double floor of the sella trucica. Plain CT scan showed an oval high density area without surrounding low density area in the left middle cranial fossa. A left carotid angiogram revealed @entity4 at the foramen lacerum. Good cross filling through the anterior communicating artery was seen in the right carotid angiogram. Pre-operative diagnosis was @entity7 which extended to the middle cranial fossa. Left fronto-temporal craniotomy was performed and the @entity0 was suspected to be a @entity5 . Post-operative carotid angiogram by prolonged injection technique also showed a blood channel in the @entity6 and a part of the @entity6 . Left carotid ligation was carried out following intracranial surgery and her symptoms were remarkably improved. Apart from left VIth @entity2 she showed no abnormal neurological findings at discharge. Usefulness of the prolonged injection technique for differential diagnosis of the parasellar @entity0 was stressed.

title: [Giant XXXX visualized by prolonged injection angiography--case report (author's transl)].

answer: @entity5


abstract: OBJECTIVE: To summarize the management of @entity0 @entity1 with @entity8 ( @entity8 ) and to evaluate the effect of drug combined with sclerotherapy. METHODS: From Feb. 2007 to Nov. 2014, 25 cases with @entity8 , who underwent drug therapy combined with sclerotherapy, were retrospectively studied. Oral @entity3 (2 mg/kg per day) was used as the first-line therapy on all of the @entity0 and intravenous @entity6 (1.5 mg/m2 every week) was added when the platelet counts didn't recover obviously after 2-3 weeks. After the recovery of the platelet counts, the @entity0 were admitted for sclerotherapy (average, 4.56 sessions per case) with 100% @entity2 (1-3 ml per session), @entity4 (1.25-5 ml per session) and @entity7 (0.25-1 ml per session). All the @entity0 were followed up for 42 months ( range, 9 months to 6.5 years). Therapeutic outcomes were assessed by evaluating platelet counts, size of lesion, function of trunk and limb. RESULTS: All the 25 cases got obvious recovery in the platelet counts [average, (94.3    18.5) x 10(9)/L] after drug therapy, of which 16 were treated by single oral @entity3 for 4-7 weeks and 9 were treated by @entity3 plus intravenous @entity6 for 2-5 weeks. Meantime, 11 cases received platelet transfusions, of which 3 were coupled with gamma globulin intramuscularly. During the first admission, each of the 25 cases received 1-4 sessions of sclerotherapy (average, 2.6 sessions each case). One week after the sclerotherapy, the platelet counts returned to (167-312) x 10(9)/L (average, (258.5    34.4) x 10(9)/L). The hemoglobin and @entity5 function returned to normal within 1-5 weeks. Meanwhile the mental condition, appetite, body weight, sleeping were greatly improved. The size of the lesions decreased gradually after the combined therapy including 13 cases within 3-12 months and 13 cases within 13-36 months. Long term follow-up indicated that only 1 case need treatment for recurrent decrease of platelet counts, and all of the 25 cases kept the normal weight, height, immunity as well as the growing development. CONCLUSIONS: Oral @entity3 plus intravenous @entity6 combined with sclerotherapy is a reliable management with high cure rate, short course and minor side-effect.

title: [Comprehensive therapy for @entity0 @entity1 associated with XXXX ].

answer: @entity8


abstract: OBJECTIVE: To summarize the management of @entity0 @entity1 with @entity8 ( @entity8 ) and to evaluate the effect of drug combined with sclerotherapy. METHODS: From Feb. 2007 to Nov. 2014, 25 cases with @entity8 , who underwent drug therapy combined with sclerotherapy, were retrospectively studied. Oral @entity3 (2 mg/kg per day) was used as the first-line therapy on all of the @entity0 and intravenous @entity6 (1.5 mg/m2 every week) was added when the platelet counts didn't recover obviously after 2-3 weeks. After the recovery of the platelet counts, the @entity0 were admitted for sclerotherapy (average, 4.56 sessions per case) with 100% @entity2 (1-3 ml per session), @entity4 (1.25-5 ml per session) and @entity7 (0.25-1 ml per session). All the @entity0 were followed up for 42 months ( range, 9 months to 6.5 years). Therapeutic outcomes were assessed by evaluating platelet counts, size of lesion, function of trunk and limb. RESULTS: All the 25 cases got obvious recovery in the platelet counts [average, (94.3    18.5) x 10(9)/L] after drug therapy, of which 16 were treated by single oral @entity3 for 4-7 weeks and 9 were treated by @entity3 plus intravenous @entity6 for 2-5 weeks. Meantime, 11 cases received platelet transfusions, of which 3 were coupled with gamma globulin intramuscularly. During the first admission, each of the 25 cases received 1-4 sessions of sclerotherapy (average, 2.6 sessions each case). One week after the sclerotherapy, the platelet counts returned to (167-312) x 10(9)/L (average, (258.5    34.4) x 10(9)/L). The hemoglobin and @entity5 function returned to normal within 1-5 weeks. Meanwhile the mental condition, appetite, body weight, sleeping were greatly improved. The size of the lesions decreased gradually after the combined therapy including 13 cases within 3-12 months and 13 cases within 13-36 months. Long term follow-up indicated that only 1 case need treatment for recurrent decrease of platelet counts, and all of the 25 cases kept the normal weight, height, immunity as well as the growing development. CONCLUSIONS: Oral @entity3 plus intravenous @entity6 combined with sclerotherapy is a reliable management with high cure rate, short course and minor side-effect.

title: [Comprehensive therapy for @entity0 XXXX associated with @entity8 ].

answer: @entity1


abstract: OBJECTIVE: To summarize the management of @entity0 @entity1 with @entity8 ( @entity8 ) and to evaluate the effect of drug combined with sclerotherapy. METHODS: From Feb. 2007 to Nov. 2014, 25 cases with @entity8 , who underwent drug therapy combined with sclerotherapy, were retrospectively studied. Oral @entity3 (2 mg/kg per day) was used as the first-line therapy on all of the @entity0 and intravenous @entity6 (1.5 mg/m2 every week) was added when the platelet counts didn't recover obviously after 2-3 weeks. After the recovery of the platelet counts, the @entity0 were admitted for sclerotherapy (average, 4.56 sessions per case) with 100% @entity2 (1-3 ml per session), @entity4 (1.25-5 ml per session) and @entity7 (0.25-1 ml per session). All the @entity0 were followed up for 42 months ( range, 9 months to 6.5 years). Therapeutic outcomes were assessed by evaluating platelet counts, size of lesion, function of trunk and limb. RESULTS: All the 25 cases got obvious recovery in the platelet counts [average, (94.3    18.5) x 10(9)/L] after drug therapy, of which 16 were treated by single oral @entity3 for 4-7 weeks and 9 were treated by @entity3 plus intravenous @entity6 for 2-5 weeks. Meantime, 11 cases received platelet transfusions, of which 3 were coupled with gamma globulin intramuscularly. During the first admission, each of the 25 cases received 1-4 sessions of sclerotherapy (average, 2.6 sessions each case). One week after the sclerotherapy, the platelet counts returned to (167-312) x 10(9)/L (average, (258.5    34.4) x 10(9)/L). The hemoglobin and @entity5 function returned to normal within 1-5 weeks. Meanwhile the mental condition, appetite, body weight, sleeping were greatly improved. The size of the lesions decreased gradually after the combined therapy including 13 cases within 3-12 months and 13 cases within 13-36 months. Long term follow-up indicated that only 1 case need treatment for recurrent decrease of platelet counts, and all of the 25 cases kept the normal weight, height, immunity as well as the growing development. CONCLUSIONS: Oral @entity3 plus intravenous @entity6 combined with sclerotherapy is a reliable management with high cure rate, short course and minor side-effect.

title: [Comprehensive therapy for XXXX @entity1 associated with @entity8 ].

answer: @entity0


abstract: OBJECT: The objective of this study was to describe a single surgeon's experience managing @entity1 due to @entity8 . METHODS: The authors undertook a retrospective review of the records of @entity0 with @entity1 due to @entity8 who were evaluated and treated by the senior author. Charts were reviewed for symptoms and signs at presentation, radiography results, treatment, and outcome. In addition, some of the @entity0 had pathology reports available for review. RESULTS: Eight @entity0 with @entity1 due to @entity8 were identified who were evaluated by the senior author in the years 1990-2008. The most common presenting symptoms were @entity11 (37.5%), @entity3 (37.5%), and @entity4 (62.5%). On examination, the most common findings were limited cervical range of motion (37.5%), @entity6 (50%), and @entity7 (75%). Radiographic evaluation revealed @entity13 , retroodontoid @entity9 formation, @entity10 , and @entity2 . Surgery was offered to all of the @entity0 , 7 of whom underwent operations. In most cases, the treatment was @entity12 followed by occipitocervical fusion. One @entity0 with a reducible lesion underwent dorsal fusion alone. Neurological outcomes were favorable overall. CONCLUSIONS: The incidence of @entity1 in @entity0 with @entity8 varies among reports. These cases are rare in most neurosurgery clinics. It is important to recognize that @entity0 with @entity8 are at risk for @entity1 , similar to @entity0 with @entity5 . Principles common to the management of other CVJ pathologies apply to these @entity0 as well.

title: XXXX of the craniovertebral junction: a single surgeon's experience.

answer: @entity8


abstract: OBJECT: @entity3 is the most common @entity5 in @entity0 . Left untreated it spreads to the brain via the optic nerve. Traditional therapy is enucleation, and while this procedure is still the most common treatment worldwide, modern eye-preserving therapies can often spare the globe. However, @entity0 with @entity3 often present in advanced stages of the disease when these globe-preserving strategies are often insufficient to prevent enucleation. In these challenging cases, direct infusion of chemotherapy into the ophthalmic artery has been attempted to achieve @entity1 control. The authors' aim in this study was to report on their initial experience with and clinical results for this approach. METHODS: The authors prospectively collected data on all cases of @entity3 treated with selective intraophthalmic melphalan at Bascom Palmer Eye Institute. All cases were classified as International Intraocular @entity3 Classification (IIRC) Group D or Reese-Ellsworth Group Vb, had not responded to aggressive multimodal therapy consisting of chemotherapy and focal consolidating laser therapy, and were pending enucleation. Using digital subtraction angiography, a microcatheter was navigated under roadmap guidance into the ophthalmic artery, and melphalan was infused over 40 minutes. Early in the series, @entity0 were treated with 3 or 5 mg of melphalan, but after low response rates occurred all eyes were treated with 7.5 mg of @entity6 . All @entity0 were examined with funduscopy while under anesthesia 3 weeks after treatment and every 3 months thereafter. @entity0 with persistent disease were retreated with repeat infusions of melphalan. RESULTS: Twenty-six procedures were performed to treat 17 @entity1 in 15 @entity0 . Successful cannulation of the ophthalmic artery was achieved in all cases. The follow-up ranged from 3 to 12 months, with a mean of 8.6 months. Overall, 76% of the @entity1 responded to therapy and these cases were spared enucleation. The average number of treatments was 1.5 per @entity1 . Of the responders, 54% responded to a single dose of melphalan. Treatment with the higher dose of 7.5 mg up front was associated with a lower enucleation rate (0% vs 36%) as compared with the lower starting dose. Delayed @entity2 occurred after 4 (15%) of 26 treatments, and these cases were treated with enucleation. CONCLUSIONS: In this challenging group of advanced @entity3 refractory to aggressive multimodal therapy, virtually 100% of eyes are generally enucleated. In contrast, the authors' protocol of infusing melphalan directly into the ophthalmic artery led to a dramatic decrease in the enucleation rate to 23.5%. While it is now the treatment of choice for refractory @entity3 at their center, its role in less @entity4 remains to be elucidated.

title: Selective ophthalmic artery infusion of chemotherapy for XXXX : initial experience with 17 @entity1 .

answer: @entity3


abstract: OBJECT: @entity3 is the most common @entity5 in @entity0 . Left untreated it spreads to the brain via the optic nerve. Traditional therapy is enucleation, and while this procedure is still the most common treatment worldwide, modern eye-preserving therapies can often spare the globe. However, @entity0 with @entity3 often present in advanced stages of the disease when these globe-preserving strategies are often insufficient to prevent enucleation. In these challenging cases, direct infusion of chemotherapy into the ophthalmic artery has been attempted to achieve @entity1 control. The authors' aim in this study was to report on their initial experience with and clinical results for this approach. METHODS: The authors prospectively collected data on all cases of @entity3 treated with selective intraophthalmic melphalan at Bascom Palmer Eye Institute. All cases were classified as International Intraocular @entity3 Classification (IIRC) Group D or Reese-Ellsworth Group Vb, had not responded to aggressive multimodal therapy consisting of chemotherapy and focal consolidating laser therapy, and were pending enucleation. Using digital subtraction angiography, a microcatheter was navigated under roadmap guidance into the ophthalmic artery, and melphalan was infused over 40 minutes. Early in the series, @entity0 were treated with 3 or 5 mg of melphalan, but after low response rates occurred all eyes were treated with 7.5 mg of @entity6 . All @entity0 were examined with funduscopy while under anesthesia 3 weeks after treatment and every 3 months thereafter. @entity0 with persistent disease were retreated with repeat infusions of melphalan. RESULTS: Twenty-six procedures were performed to treat 17 @entity1 in 15 @entity0 . Successful cannulation of the ophthalmic artery was achieved in all cases. The follow-up ranged from 3 to 12 months, with a mean of 8.6 months. Overall, 76% of the @entity1 responded to therapy and these cases were spared enucleation. The average number of treatments was 1.5 per @entity1 . Of the responders, 54% responded to a single dose of melphalan. Treatment with the higher dose of 7.5 mg up front was associated with a lower enucleation rate (0% vs 36%) as compared with the lower starting dose. Delayed @entity2 occurred after 4 (15%) of 26 treatments, and these cases were treated with enucleation. CONCLUSIONS: In this challenging group of advanced @entity3 refractory to aggressive multimodal therapy, virtually 100% of eyes are generally enucleated. In contrast, the authors' protocol of infusing melphalan directly into the ophthalmic artery led to a dramatic decrease in the enucleation rate to 23.5%. While it is now the treatment of choice for refractory @entity3 at their center, its role in less @entity4 remains to be elucidated.

title: Selective ophthalmic artery infusion of chemotherapy for @entity3 : initial experience with 17 XXXX .

answer: @entity1


abstract: The ENOD40 gene, found in several leguminous and non-leguminous plant species is expressed in the pericycle of legume roots early in the nodulation process, adjacent to the protoxylem poles, but before the cortical cells divide to form the nodule itself. The ENOD40 transcript contains only short open reading frames which give rise to short peptides with a signaling function. The current work reports the cloning and analysis of ENOD40 genes from @entity6 ( @entity6 ) and @entity4 ( @entity4 ). Specific polymerase chain reaction (PCR) techniques lead to the isolation of a 659 bp cDNA encoding an ENOD40 homologue, designated LpE-NOD40, from a @entity6 stem cDNA library. In addition, a partial ENOD40 cDNA of 384 bp was isolated from @entity4 ( @entity4 ) by RT-PCR cloning. The LpENOD40 transcript encodes a putative dodecapeptide, similar to that identified in ENOD40s from leguminous plants and other dicots, and also to ENOD40s from monocots. The coding sequences of ryegrass and @entity4 ENOD40 are represented by a short open reading frame of 12 @entity3 . These show a high degree of similarity to each other and to other ENOD40 sequences from monocots. The corresponding genomic DNA from a genomic ryegrass lambda library revealed that the LpENOD40 gene contains no introns. Southern blot analysis shows that the ryegrass genome contains a single copy, possibly two copies, of the gene. Alignment of the ENOD40 cDNA sequences from ryegrass and @entity4 revealed high (77%) @entity0 homology. The ENOD40 peptides are highly conserved, not only among monocots but also on comparison with the dicot peptides. The @entity1 identity of region I from ryegrass with its counterparts in @entity5 , @entity4 and @entity2 is 92, 83 and 75% respectively. Expression analysis by RT-PCR demonstrates that a high level of LpENOD40 gene transcript was found expressed in stem tissue, while a lower level was detected in leaves and only a very low expression in flowers of @entity6 . No LpENOD40 transcript was detected in roots.

title: Molecular cloning and characterization of a cDNA encoding a ryegrass ( XXXX ) ENOD40 homologue.

answer: @entity6


abstract: Twenty @entity0 varying in age between 5 and 20 years at the time of surgical closure of @entity6 were studied 2 to 9 years postoperatively. Ventricular function was studied by echocardiography and measurement of systolic time intervals for the left and right ventricles and the findings were related to clinical and haemodynamic results of operation. The @entity6 was closed in all instances and the haemodynamic situation was normalized in all but 2 @entity0 who had persisting @entity3 . @entity4 ( @entity4 ) was recorded in 11 instances and in 5 there was an associated @entity7 ( @entity7 ), suggesting @entity5 . @entity7 occurred as an @entity2 in another 2 @entity0 . The heart size was within normal limits in all the @entity0 . @entity6 ( @entity6 ) was recorded in 13 of the 20 @entity0 , but other echocardiographic analyses, such as LV end-diastolic dimension, left atrial/aortic root ratio, posterior wall velocity index and maximal endocardial velocity, were all within predicted normal limits. There was an almost uniform prolongation of both left and right pre-ejection periods. left and right ejection period as a rule remained normal and gave an increased PEP/ET ratio, indicating the presence of postoperative @entity1 also in instances with complete normalization of the haemodynamic situation. Suggested background mechanisms for these findings are the frequent occurrence of conduction defects postoperatively, the likelihood of altered ventricular compliance and possibly also as a cause of @entity6 postoperative presence of an opened pericardial sac.

title: Ventricular dynamics after surgical closure of XXXX .

answer: @entity6


abstract: Subjects were 51 @entity0 undergoing folded pharyngeal flap surgery for @entity6 at the Department of Otolaryngology of Kagawa Medical University between August 1985 and July 2001. @entity1 were @entity7 in 27 (53%), @entity7 in 8 (16%), and @entity6 in 16 (31%). In history, 31% with @entity6 , 25% with @entity7 , and 11% with @entity7 had @entity2 . In addition, 56% with @entity6 , 38% with @entity7 , and 15% with @entity7 had @entity4 , indicating that it occurred with high frequency in @entity0 with @entity6 . The postoperative improvement of nasality was investigated in 48 @entity0 whose progress could be observed for more than 1 year. Of 39 preoperatively diagnosed with advanced velopharyngeal dysfunction, 34 (87%) showed improved nasality. Of 9 with preoperatively @entity3 , 8 (89%) improved nasality. The blowing test showed no difference in results between @entity0 who had advanced and @entity3 . Articulation on speech level improved to be normal in 78% of @entity0 with @entity3 , but only in 46% of those with @entity5 . Improvement of articulation on a speech level was high (86%) in @entity0 with @entity7 , but low in @entity0 with @entity6 who had @entity4 . Further study is required to detail postoperative prognosis factors.

title: [Clinical analysis of XXXX in @entity0 with folded pharyngeal flap].

answer: @entity6


abstract: Subjects were 51 @entity0 undergoing folded pharyngeal flap surgery for @entity6 at the Department of Otolaryngology of Kagawa Medical University between August 1985 and July 2001. @entity1 were @entity7 in 27 (53%), @entity7 in 8 (16%), and @entity6 in 16 (31%). In history, 31% with @entity6 , 25% with @entity7 , and 11% with @entity7 had @entity2 . In addition, 56% with @entity6 , 38% with @entity7 , and 15% with @entity7 had @entity4 , indicating that it occurred with high frequency in @entity0 with @entity6 . The postoperative improvement of nasality was investigated in 48 @entity0 whose progress could be observed for more than 1 year. Of 39 preoperatively diagnosed with advanced velopharyngeal dysfunction, 34 (87%) showed improved nasality. Of 9 with preoperatively @entity3 , 8 (89%) improved nasality. The blowing test showed no difference in results between @entity0 who had advanced and @entity3 . Articulation on speech level improved to be normal in 78% of @entity0 with @entity3 , but only in 46% of those with @entity5 . Improvement of articulation on a speech level was high (86%) in @entity0 with @entity7 , but low in @entity0 with @entity6 who had @entity4 . Further study is required to detail postoperative prognosis factors.

title: [Clinical analysis of @entity6 in XXXX with folded pharyngeal flap].

answer: @entity0


abstract: Abstract @entity3 is the most common nosocomial pathogen among all @entity3 spp. A. baumannii tend to be resistant to multiple antibiotics, and represent a severe threat in the treatment of hospitalized @entity0 . The purpose of this study was to evaluate the prevalence, biotyping, and antibiotic resistance status of A. baumannii isolates recovered from submitted hospital clinical specimens. The in-vitro activity of 29 currently used antimicrobial agents was studied in 180 isolates of A. baumannii. The prevalence was higher in wound exudates (32%) and urine samples (22%) than in other specimens. Forty-six percent of the isolates were of biotype 9. The evolution of resistance from November 1996 through October 1998 was studied. More than 75% of the isolates were multidrug resistant (MDR) and more than 70% were #-lactamase producers. @entity5 , @entity1 + @entity7 , and @entity2 are still effective antimicrobial agents, but a steady rise in the values of the minimum inhibitory concentration at which 50% of the isolates were inhibited (MIC50 )and MIC90 was observed. Resistance to @entity6 (60%), @entity8 (60%), @entity2 (29%), @entity4 (73%), and @entity9 (25%) was noted; @entity8 and @entity9 are not generally used in this hospital. From the findings of the present study, no single drug appears to be suitable for empirical therapy for this nosocomial pathogen. Abstract @entity3 is the most common nosocomial pathogen among all @entity3 spp. A. baumannii tend to be resistant to multiple antibiotics, and represent a severe threat in the treatment of hospitalized @entity0 . The purpose of this study was to evaluate the prevalence, biotyping, and antibiotic resistance status of A. baumannii isolates recovered from submitted hospital clinical specimens. The in-vitro activity of 29 currently used antimicrobial agents was studied in 180 isolates of A. baumannii. The prevalence was higher in wound exudates (32%) and urine samples (22%) than in other specimens. Forty-six percent of the isolates were of biotype 9. The evolution of resistance from November 1996 through October 1998 was studied. More than 75% of the isolates were multidrug resistant (MDR) and more than 70% were #-lactamase producers. @entity5 , @entity1 + @entity7 , and @entity2 are still effective antimicrobial agents, but a steady rise in the values of the minimum inhibitory concentration at which 50% of the isolates were inhibited (MIC50) and MIC90 was observed. Resistance to @entity6 (60%), @entity8 (60%), @entity2 (29%), @entity4 (73%), and @entity9 (25%) was noted; @entity8 and @entity9 are not generally used in this hospital. From the findings of the present study, no single drug appears to be suitable for empirical therapy for this nosocomial pathogen.

title: Multidrug resistant XXXX isolates from a teaching hospital.

answer: @entity3


abstract: Isolated atelectasis of the middle lobe has been known for many years as the " @entity4 ". Several clinical studies have shown that it may bae caused by @entity1 . A 10-year study of 135 @entity0 with isolated @entity4 is presented. Fifty-eight @entity0 (43%) had @entity1 . Of 38 who had a thoracotomy, lung resection was possible in 25. In 20 @entity0 regional or systemic dissemination of the @entity1 had been diagnosed before operation. Seventy-seven @entity0 had benign diseases, of which 74 were non-specific infections. Bronchography was performed in 46 of these cases, and all had abnormal findings in the middle lobe, eight revealing definite @entity3 . In three cases @entity2 was found. In 16 cases the benign diagnosis was established at thoracotomy. Only three @entity0 out of 58 with @entity1 lived more than five years. Atelectasis of the middle lobe is always a sign of potential @entity1 especially in @entity0 with a previously normal chest radiograph.

title: Isolated XXXX : aetiology, pathogenesis, and treatment of the so-called @entity4 .

answer: @entity4


abstract: Isolated atelectasis of the middle lobe has been known for many years as the " @entity4 ". Several clinical studies have shown that it may bae caused by @entity1 . A 10-year study of 135 @entity0 with isolated @entity4 is presented. Fifty-eight @entity0 (43%) had @entity1 . Of 38 who had a thoracotomy, lung resection was possible in 25. In 20 @entity0 regional or systemic dissemination of the @entity1 had been diagnosed before operation. Seventy-seven @entity0 had benign diseases, of which 74 were non-specific infections. Bronchography was performed in 46 of these cases, and all had abnormal findings in the middle lobe, eight revealing definite @entity3 . In three cases @entity2 was found. In 16 cases the benign diagnosis was established at thoracotomy. Only three @entity0 out of 58 with @entity1 lived more than five years. Atelectasis of the middle lobe is always a sign of potential @entity1 especially in @entity0 with a previously normal chest radiograph.

title: Isolated @entity4 : aetiology, pathogenesis, and treatment of the so-called XXXX .

answer: @entity4


abstract: OBJECTIVE: The population of @entity0 who received right ventricle-to-pulmonary artery shunt (RV-PA) at Norwood procedure (NP) is growing, but limited data are available regarding the long-term outcome. The aim of this study was to present operative outcomes and mid-term hemodynamics and to assess the impact of the residual @entity5 on the results in @entity0 undergoing three-staged surgery with RV-PA application at NP. METHODS: Between June 2001 and June 2009, 229 @entity0 with @entity4 ( @entity4 ) and variants underwent NP with RV-PA; 172 have proceeded to stage II and 95 to stage III. The medical records (clinical data, echocardiographic records, cardiac catheterization reports, electrocardiograms, and surgical notes) were retrospectively reviewed. RESULTS: The later era of NP was associated with significantly better outcome (2001-2004: 1- and 5-years' survival were 64.3% and 59.8%, respectively; 2005-2009: 1- and 4-years' survival were 93.1% and 86.9%, respectively) (p<0.001). There was no association between long-term survival and diagnosis ( @entity4 / @entity4 variant) (p=0.39). The incidence of @entity1 and moderate or severe systemic @entity2 among the @entity0 who required balloon aortoplasty (BA) before stage II surgery was significantly higher than in @entity0 without aortic arch obstruction (p=0.027, p=0.008, respectively). In midterm follow-up, BA had no significant influence on the actuarial survival (p=0.089). No @entity3 were noticed at any stage. CONCLUSIONS: The RV-PA shunt is a safe technique that does not seem to impair systolic or electrical ventricular function; its outcomes continue to improve with growing experience. Combined cardiologic interventional and surgical procedures are required to optimize the outcomes.

title: Significance of the residual XXXX in multistage repair of @entity4 .

answer: @entity5


abstract: OBJECTIVE: The population of @entity0 who received right ventricle-to-pulmonary artery shunt (RV-PA) at Norwood procedure (NP) is growing, but limited data are available regarding the long-term outcome. The aim of this study was to present operative outcomes and mid-term hemodynamics and to assess the impact of the residual @entity5 on the results in @entity0 undergoing three-staged surgery with RV-PA application at NP. METHODS: Between June 2001 and June 2009, 229 @entity0 with @entity4 ( @entity4 ) and variants underwent NP with RV-PA; 172 have proceeded to stage II and 95 to stage III. The medical records (clinical data, echocardiographic records, cardiac catheterization reports, electrocardiograms, and surgical notes) were retrospectively reviewed. RESULTS: The later era of NP was associated with significantly better outcome (2001-2004: 1- and 5-years' survival were 64.3% and 59.8%, respectively; 2005-2009: 1- and 4-years' survival were 93.1% and 86.9%, respectively) (p<0.001). There was no association between long-term survival and diagnosis ( @entity4 / @entity4 variant) (p=0.39). The incidence of @entity1 and moderate or severe systemic @entity2 among the @entity0 who required balloon aortoplasty (BA) before stage II surgery was significantly higher than in @entity0 without aortic arch obstruction (p=0.027, p=0.008, respectively). In midterm follow-up, BA had no significant influence on the actuarial survival (p=0.089). No @entity3 were noticed at any stage. CONCLUSIONS: The RV-PA shunt is a safe technique that does not seem to impair systolic or electrical ventricular function; its outcomes continue to improve with growing experience. Combined cardiologic interventional and surgical procedures are required to optimize the outcomes.

title: Significance of the residual @entity5 in multistage repair of XXXX .

answer: @entity4


abstract: Antiphospholipid antibodies (aPL) have been suggested to play a role in causing cognitive and @entity2 . In the present study we investigated the pathogenic potential of aPL by intracerebro-ventricular (ICV) administration of immunoglobulins (IgG) from patients with @entity3 ( @entity3 ). IgG, purified from the sera of four @entity3 @entity0 , was tested for binding to normal @entity1 brain by immunohistological staining. These IgG (7.5 microg) were injected ICV unilaterally to male C3H @entity1 . @entity1 injected with IgG purified from pooled sera derived from healthy subjects served as controls. The @entity1 were examined neurologically for motor function and coordination, and cognitively in a Morris water maze. The cognitive tests were performed with the experimenter blinded to the treatment. The performance of the @entity1 in four separate experiments was compared by analysis of variance with repeated measures. IgG from one @entity3 @entity0 was found to bind best to neuronal structures in the hippocampus and cerebral cortex. @entity1 (n = 43) injected with this IgG performed worse in the water maze compared to the controls (n = 45) with significant effects of the aPL IgG on the overall performance of the @entity1 (treatment, P < 0.03), on learning throughout the experiment (treatment x day, P < 0.02) and on short term memory (treatment x day xtrial, P < 0.002). IgG injected from two of the three other @entity0 also bound specifically to @entity1 brain neurons and produced an impairment in performance of the water maze. These results support the hypothesis that aPL that gain access to the central nervous system may play a direct role in the pathogenesis of neurological manifestations of @entity3 .

title: Neuronal-binding antibodies from patients with XXXX induce cognitive deficits following intrathecal passive transfer.

answer: @entity3


abstract: Our objective was to review current large studies of @entity2 ) DNA testing as an adjunct to the Papanicolaou test for cervical @entity1 screening programs. We analyzed 10 large screening studies that used the Hybrid Capture 2 test and 3 studies that used the polymerase chain reaction test in a manner that enabled reliable estimates of accuracy for detecting or predicting high-grade @entity3 ( @entity3 ). Most studies allowed comparison of HPV DNA and Papanicolaou testing and estimates of the performance of Papanicolaou and HPV DNA as combined tests. The studies were selected on the basis of a sufficient number of cases of high-grade @entity3 and @entity1 to provide meaningful statistical values. Investigators had to demonstrate the ability to generate reasonably reliable Hybrid Capture 2 or polymerase chain reaction data that were either minimally biased by nature of study design or that permitted analytical techniques for addressing issues of study bias to be applied. Studies had to provide data for the calculation of test sensitivity, specificity, predictive values, odds ratios, relative risks, confidence intervals, and other relevant measures. Final data were abstracted directly from published articles or estimated from descriptive statistics presented in the articles. In some studies, new analyses were performed from raw data supplied by the principal investigators. We concluded that HPV DNA testing was a more sensitive indicator for prevalent high-grade @entity3 than either conventional or liquid cytology. A combination of HPV DNA and Papanicolaou testing had almost 100% sensitivity and negative predictive value. The specificity of the combined tests was slightly lower than the specificity of the Papanicolaou test alone, but this decrease could potentially be offset by greater protection from neoplastic progression and cost savings available from extended screening intervals. One "double-negative" HPV DNA and Papanicolaou test indicated better prognostic assurance against risk of future @entity3 3 than 3 subsequent negative conventional Papanicolaou tests and may safely allow 3-year screening intervals for such low-risk @entity0 .

title: XXXX DNA testing as an adjunct to cytology in cervical screening programs.

answer: @entity2


abstract: AIMS: The application of felted foam is a promising method for plantar pressure reduction in the @entity3 region of @entity5 , but knowledge of its effects on wound healing is sparse. The objective of this study was to evaluate the effects of felted foam on wound healing in @entity5 compared with a standard method of plantar pressure relief. MATERIALS AND METHODS: A total of 54 Type 1 or Type 2 @entity1 @entity0 with neuropathic @entity5 were evaluated in this prospective randomized controlled study. @entity3 was assessed by planimetric measurement of the wound area at beginning of the study and after 10 weeks and at least until wound healing. The @entity0 were consecutively enrolled in the study; 24 @entity0 were randomized to the felted foam therapy, and 30 @entity0 were randomized to conventional therapy. RESULTS: In the felted foam group, the initial average wound area was 102.3 +/- 45.3 @entity2 (mean +/- sd), and 5.4 +/- 3.1 @entity2 after 10 weeks with an average healing time of 75 days [95% confidence interval (CI) 67-84]. In the conventional therapy group, the initial average wound area was 112.5 +/- 50.8 @entity2 , and 10.6 +/- 4.2 @entity2 after 10 weeks with an average healing time of 85 days (95% CI 79-92) (P = 0.03). The mean wound radius decreased by 0.48 mm (95% CI 0.42-0.56) per week in the felted foam group and by 0.39 mm (95% CI 0.35-0.42) per week in the conventional group (P = 0.005). CONCLUSIONS: The felted foam technique appears to be at least as effective as @entity4 treatment. It may be a useful alternative in treating @entity4 , especially in @entity0 who are not able to avoid weight-bearing reliably.

title: The effects of applied felted foam on wound healing and healing times in the therapy of neuropathic XXXX .

answer: @entity5


abstract: BACKGROUND: The inflammatory cascade has emerged as the primary mediator of reperfusion injury. Nuclear factor kappaB (NF-kappaB) is a rapid response transcription factor that activates genes responsible for the mediators of @entity0 . @entity4 protein 70 (HSP70) has been shown to protect against @entity3 . We hypothesized that the antioxidant @entity5 ( @entity6 ), an inhibitor of NF-kappaB and upregulator of HSP70, would decrease @entity3 after @entity1 and reperfusion. METHODS: Using our isolated, ventilated, blood-perfused @entity2 lung model, all groups underwent lung harvest followed by 10-h storage (4 degrees C) and blood reperfusion for 30 min. Group I lungs (n = 5) served as controls. In group II lungs (n = 5), both lung and blood donors received @entity6 (100 mg/kg) intravenously 30 min before harvest. NF-kappaB activity was evaluated with electrophoretic mobility shift assay, and Western blot was performed for HSP70. RESULTS: Group II demonstrated superior pulmonary function. Although HSP70 expression was somewhat elevated in group II lungs, NF-kappaB binding activity was not different between the groups. CONCLUSIONS: @entity6 improves pulmonary function after @entity1 and reperfusion in an isolated @entity2 lung model. The improved function correlates with elevated HSP70 expression during initial reperfusion, independent of NF-kappaB activity.

title: XXXX reduces lung reperfusion injury.

answer: @entity5


abstract: PURPOSE: The North Central @entity1 Treatment Group performed a phase III trial to determine whether chemotherapy plus either bid radiation therapy (RT) or daily (qd) RT resulted in a better outcome for @entity0 with @entity1 ( @entity5 ). No difference in survival was identified between the two arms. This secondary analysis was performed to examine the relationship between @entity0 age and outcome. @entity0 AND METHODS: Two hundred forty-six @entity0 were randomized to receive @entity6 plus @entity4 and either RT qd or split-course RT bid. This retrospective study compared the outcomes of @entity0 aged >/=70 years ("elderly @entity0 ") with those of younger individuals. Of the 244 assessable @entity0 , 63 (26%) were elderly, and 181 (74%) were younger individuals. RESULTS: The 2-year and 5-year survival rates were 39% and 18%, respectively, in @entity0 younger than 70 years, compared with 36% and 13%, respectively, in elderly @entity0 (P =.4). Grade 4+ @entity3 occurred in 62% of @entity0 younger than 70 years compared with 81% of elderly @entity0 (P =.007). Grade 4+ hematologic @entity3 occurred in 56% of @entity0 younger than 70 years, compared with 78% of elderly @entity0 (P =.003). Grade 4+ @entity2 occurred in 1% of those younger than 70 years, compared with 6% of elderly @entity0 (P =.02). CONCLUSION: @entity3 , especially myelosuppression and @entity2 , was more pronounced in the elderly @entity0 receiving combined-modality therapy for locally advanced @entity5 . Despite increased @entity3 , elderly @entity0 have survival rates equivalent to younger individuals. Therefore, fit, elderly @entity0 with locally advanced @entity5 should be encouraged to receive combined-modality therapy, preferably on clinical trials with cautious, judicious monitoring. Future studies should explore ways to decrease @entity3 of therapy in elderly @entity0 .

title: The outcome of combined-modality therapy for XXXX in the elderly.

answer: @entity1


abstract: BACKGROUND: Face imagery can access facial memories without the use of perceptual stimuli. Current data on the relation of imagery to the perceptual function and neuroanatomy of prosopagnosic @entity0 are mixed, and little is known about the type of facial information @entity0 can access through imagery. OBJECTIVE: The authors wished to determine 1) which lesions abolished face imagery in @entity2 , 2) if deficits in perceiving facial structure were paralleled by similar deficits in imagery, and 3) if covert recognition of faces correlated with the degree of residual imagery for faces. METHODS: The authors tested nine prosopagnosic @entity0 who had been tested previously for perception of facial configuration and covert recognition of famous faces. The authors constructed a battery of 37 questions that asked subjects to imagine the faces of two celebrities and to choose which one had a certain facial property. Half were questions about facial features and half were about overall facial shape. RESULTS: Imagery was abolished only by anterior temporal lesions. Imagery for facial shape but not features was degraded by lesions of the right hemisphere's fusiform face area, which severely @entity1 . Feature imagery was degraded only when there was associated left occipito-temporal damage. Covert recognition was found when either configural perception or imagery was severely damaged, but not when both were abnormal. In @entity0 with @entity1 , covert recognition correlated with feature imagery, suggesting that feature-based processing may drive residual covert abilities in these @entity0 . CONCLUSION: Although anterior temporal cortex may be the site of facial memory stores, these data also support hypotheses that perceptual areas like the fusiform face area have parallel contributions to mental imagery. The data on covert recognition are consistent with a view that it is the residue of a partially damaged face-recognition network. Covert recognition may reflect the degree of damage across components of a network rather than mark a specific form of @entity2 or a dissociated pathway.

title: Face imagery and its relation to perception and covert recognition in XXXX .

answer: @entity2


abstract: RATIONALE AND OBJECTIVES: In @entity5 ( @entity5 ), a pediatric @entity2 that may be mistaken for nonaccidental @entity3 , expeditious detection is critical as early treatment may substantially improve @entity4 . In this study, we examine in depth the magnetic resonance (MR) findings, with special attention to the basal ganglia, in 4 new cases and compare the findings with those described in the literature. METHODS: MR studies of 4 @entity0 , diagnosed to have @entity5 via cultured fibroblast enzyme studies or urine metabolite assays, were performed on a 1.5 T system in the axial plane using spin echo T(1)-weighted, fast spin echo T(2)-weighted, and fluid-attenuated inversion recovery (FLAIR) technique. Three of 4 @entity0 were followed with serial exams to document temporal evolution of the disease. RESULTS: On T(2)-weighted images, abnormal increased signal intensity was seen in both the putamen and globus pallidus in all cases. However, in contradistinction to cases reported in the literature, involvement of the caudate nucleus was minimal or absent even on serial MR exams. In @entity0 15 months and older, FLAIR improved recognition of basal ganglia and @entity1 . The previously described widened cerebrospinal fluid spaces anterior to the temporal lobes, increased T(2)-weighted signal intensity in the periventricular white matter, and widened sylvian fissures characteristic of @entity5 were noted in all @entity0 . CONCLUSIONS: Abnormalities of the caudate nucleus are not a prominent presentation of these @entity0 and the absence of this finding should not exclude a diagnosis of @entity5 . FLAIR scans, as an adjunct to more conventional T(1)- and T(2)-weighted sequences, can play an important role in @entity0 15 months or older despite immature myelination in these @entity0 .

title: Magnetic resonance imaging of the brain in XXXX : a review of the literature and a report of four new cases with attention to the basal ganglia and imaging technique.

answer: @entity5


abstract: Uncontrolled donation after @entity1 (DCD) could increase the donor pool in the UK. Air ambulance (AA) teams may be well placed to recruit these donors. They cover large geographical areas, have short transfer times and tasked predominantly to life-threatening cases. The potential to recruit from this pool of donors was reviewed. Seventy-five month activity of an AA unit was analysed identifying @entity0 who entered prehospital @entity2 (PHCA). @entity0 over 70 years of age were excluded as were those whose @entity2 was unwitnessed. A minimum potential donor pool was estimated based upon @entity0 dying of medical causes. Rates of bystander resuscitation, mechanism of @entity1 and @entity0 demographic data were observed. During 10,022 missions 534 @entity0 entered @entity3 . A total of 106 @entity0 met inclusion criteria. There were 12 paediatric cases; 39 cases of 17-50 year olds and 55 cases of 50-70 year olds. Medical and traumatic causes of @entity1 accounted for 60 and 46 cases respectively. Bystander resuscitation efforts were provided in 47% of cases. A regional AA could contribute to a national uncontrolled DCD programme. Given that there are 31 AA's in England and Wales, we estimate that there could be a minimum of 300 additional potential donors annually.

title: Uncontrolled organ donation following prehospital XXXX : a potential solution to the shortage of organ donors in the United Kingdom?

answer: @entity2


abstract: BACKGROUND: Accurate measurement of quality of life in older ICU survivors is difficult but critical for understanding the long-term impact of our treatments. Activities of daily living (ADLs) are important components of functional status and more easily measured than quality of life (QOL). We sought to determine the cross-sectional associations between disability in ADLs and QOL as measured by version one of the Short Form 12-item Health Survey (SF-12) at both one month and one year post-ICU discharge. METHODS: Data was prospectively collected on 309 @entity0 over age 60 admitted to the Yale-New Haven Hospital Medical ICU between 2002 and 2004. Among survivors an assessment of ADL's and QOL was performed at one month and one-year post-ICU discharge. The SF-12 was scored using the version one norm based scoring with 1990 population norms. Multivariable regression was used to adjust the association between ADLs and QOL for important covariates. RESULTS: Our analysis of SF-12 data from 110 @entity0 at one month post-ICU discharge showed that @entity1 and @entity2 were associated with decreased QOL. Our model accounted for 17% of variability in SF12 physical scores (PCS) and 20% of variability in SF12 mental scores (MCS). The mean PCS of 37 was significantly lower than the population mean whereas the mean MCS score of 51 was similar to the population mean. At one year mean PCS scores improved and @entity2 was no longer significantly associated with QOL. Mortality was 17% (53 @entity0 ) at ICU discharge, 26% (79 @entity0 ) at hospital discharge, 33% (105 @entity0 ) at one month post ICU admission, and was 45% (138 @entity0 ) at one year post ICU discharge. CONCLUSIONS: In our population of older ICU survivors, disability in ADLs was associated with reduced QOL as measured by the SF-12 at one month but not at one year. Although better markers of QOL in ICU survivors are needed, ADLs are a readily observable outcome. In the meantime, clinicians must try to offer realistic estimates of prognosis based on available data and resources are needed to assist ICU survivors with impaired ADLs who wish to maintain their independence. More aggressive diagnosis and treatment of @entity1 in this population should also be explored as an intervention to improve quality of life.

title: Disability in activities of daily living, XXXX , and quality of life among older medical ICU survivors: a prospective cohort study.

answer: @entity1


abstract: A series of 518 @entity0 with @entity1 and a median age of 78 years was followed for 6 months. On admission to hospital the @entity0 were assessed and were found to be evenly distributed among four social function groups according to their level of dependence on the social welfare system. At the 6 months follow-up the mortality rate was about 16 per cent, leaving 437 @entity0 for a reassessment of social function. The average hospitalization time was 23 days; thus 17 per cent of all orthopaedic hospital beds in the area were occupied by @entity0 with @entity1 . @entity0 staying the longest time in hospital were those waiting for discharge to a nursing home. The average stay in rehabilitation institutions was 71 days. The total rehabilitation course was longest for the most dependent @entity0 . The risk of @entity3 or deterioration of social function among @entity0 admitted from home was 48 per cent. In the case of social deterioration or technical failure following the @entity2 treatment the total rehabilitation course was considerably prolonged. The resources required for the treatment of @entity1 in a suburban area of 500,000 inhabitants were calculated to the 32 hospital beds, 43 rehabilitation beds and at least 21 nursing home beds.

title: Costs of treatment of XXXX . A calculation of the consumption of the resources of hospitals and rehabilitation institutions.

answer: @entity1


abstract: The effect of @entity4 on corrected QT interval (QTc) was studied retrospectively in 111 survivors of AMI below 70 years of age. Prior to discharge the @entity0 were stratified by age, @entity3 size and @entity1 and randomized. @entity4 , 100 mg b.i.d., or placebo were given double-blindly to 59 and 52 @entity0 , respectively. QTc intervals were measured four times prior to randomization and three times during the follow-up year. The highest QTc mean was registered on the second day in the CCU. QTc intervals subsequently decreased significantly in both groups between discharge and the three-month control (p < 0.001). @entity0 on @entity4 had significantly shorter QTc intervals during the follow-up year than those on placebo (0.394 +/- 0.028 vs. 0.406 +/- 0.034 sec, p < 0.001). The QTc-shortening effect of beta-receptor blockade was most marked in @entity0 with @entity2 at discharge. @entity0 who died suddenly had @entity2 prior to discharge. In this group the proposed beneficial effect of beta-receptor blockade on QTc interval cannot be evaluated as most of these @entity0 had died before the first control.

title: Effect of XXXX on QTc intervals after acute myocardial infarction.

answer: @entity4


abstract: BACKGROUND: Computational models play an increasingly important role in the assessment and control of public health crises, as demonstrated during the 2009 H1N1 influenza pandemic. Much research has been done in recent years in the development of sophisticated data-driven models for realistic computer-based simulations of @entity1 spreading. However, only a few computational tools are presently available for assessing scenarios, predicting @entity2 evolutions, and managing health emergencies that can benefit a broad audience of users including policy makers and health institutions. RESULTS: We present "GLEaMviz", a publicly available software system that simulates the spread of emerging @entity0 -to- @entity0 @entity1 across the world. The GLEaMviz tool comprises three components: the client application, the proxy middleware, and the simulation engine. The latter two components constitute the GLEaMviz server. The simulation engine leverages on the Global Epidemic and Mobility (GLEaM) framework, a stochastic computational scheme that integrates worldwide high-resolution demographic and mobility data to simulate disease spread on the global scale. The GLEaMviz design aims at maximizing flexibility in defining the disease compartmental model and configuring the simulation scenario; it allows the user to set a variety of parameters including: compartment-specific features, transition values, and environmental effects. The output is a dynamic map and a corresponding set of charts that quantitatively describe the geo-temporal evolution of the disease. The software is designed as a client-server system. The multi-platform client, which can be installed on the user's local machine, is used to set up simulations that will be executed on the server, thus avoiding specific requirements for large computational capabilities on the user side. CONCLUSIONS: The user-friendly graphical interface of the GLEaMviz tool, along with its high level of detail and the realism of its embedded modeling approach, opens up the platform to simulate realistic @entity2 scenarios. These features make the GLEaMviz computational tool a convenient teaching/training tool as well as a first step toward the development of a computational tool aimed at facilitating the use and exploitation of computational models for the policy making and scenario analysis of @entity1 outbreaks.

title: The GLEaMviz computational tool, a publicly available software to explore realistic XXXX spreading scenarios at the global scale.

answer: @entity2


abstract: STUDY OBJECTIVE: We investigate the incidence of adverse events at 1 year in the cohort of @entity3 ( @entity3 ) @entity9 @entity0 enrolled in the original Risk Stratification of @entity9 in the Emergency Department (ROSE) study, the time to adverse event, and the test performance of the ROSE decision instrument to detect events at 1 year. METHODS: This report details the 1-year follow-up of adult @entity9 @entity0 presenting to the @entity3 who were enrolled into the ROSE study, a single-center, prospective, observational cohort study. The primary endpoint was the combination of serious outcome and all-cause @entity2 at 1 year. Serious outcome encompassed @entity7 , life-threatening @entity8 , need for pacemaker/implantable defibrillator, @entity4 , @entity1 , @entity5 , and interventional procedure or @entity6 requiring blood transfusion. Secondary endpoints were all-cause @entity2 and cardiovascular serious outcome at 1 year. RESULTS: One thousand forty-three @entity0 were available for analysis; 162 @entity0 (15.5%) had a primary outcome. Twenty-eight (17%) of these were within 24 hours, 56 (35%) were within 1 week, and 78 (48%) were within 1 month. The remaining 84 (52%) outcomes occurred between months 2 and 12. At 1 year, 71 (6.8%) @entity0 had died and 76 (7.3%) had a cardiovascular serious outcome. The sensitivity and specificity of the ROSE decision instrument for 1-year serious outcome and all-cause @entity2 were, respectively, 71.6% (95% confidence interval [CI] 63.9% to 78.3%) and 71.1% (95% CI 67.9% to 74.0%); for 1-year all-cause @entity2 , 76.1% (95% CI 64.2% to 85.1%) and 67.4% (95% CI 64.3% to 70.3%); and for 1-year cardiovascular serious outcome, 75.0% (95% CI 63.5% to 83.9%) and 67.5% (95% CI 64.5% to 70.5%). CONCLUSION: The proportion of @entity0 with serious outcome and all-cause @entity2 1 year after @entity9 is similar to that reported in recent international @entity9 studies. We have defined the proportion of @entity0 with cardiovascular serious outcome at 1 year and have shown that most events occurred in the first month, with decreased frequency of events observed after that time especially marked for cardiovascular serious outcome. More than 50% of the outcomes observed, however, occurred after the first month. The ROSE decision instrument does not perform well at predicting 1-year outcome of @entity9 @entity0 .

title: One-year prognosis after XXXX and the failure of the ROSE decision instrument to predict one-year adverse events.

answer: @entity9


abstract: Elastofibroma dorsi is a relatively rare soft-tissue @entity1 localized at the infra-scapular level and/or subscapular regions. It usually occurs between the fourth and seventh decade of life, and is more common in females. We reviewed sixteen elastofibromas diagnosed in 12 @entity0 (7 females, 58.3%). Four @entity0 had bilateral elastofibromas. The most common symptom was @entity2 . Presumptive diagnosis was made by physical examination. Chest ultrasound, computed tomography and/or magnetic resonance imaging were performed to confirm the diagnosis. Surgery was performed under general anaesthesia. No major complications were observed. Elastofibromas are @entity1 of the chest wall with an uncertain impact. Surgical resection is indicated only in symptomatic @entity0 .

title: Elastofibroma dorsi: an uncommon and under-diagnosed XXXX .

answer: @entity1


abstract: BACKGROUND: The reasons for the down-regulated Clara cell 10-kDa protein ( @entity6 ) expression in @entity4 ( @entity4 ) are unclear and the airway remodeling in @entity4 has received little attention. This study explores epithelium remodeling and the change of @entity6 secreting cells in @entity4 by using a @entity0 model. METHODS: @entity4 @entity0 models were established by ovalbumin sensitization and challenge. In some @entity0 , @entity1 was given before each challenge. Histological changes of nasal mucosa were examined by means of @entity2 and @entity3 and periodic acid-Schiff staining. @entity6 and @entity5 expression were evaluated by immunohistochemistry. RESULTS: In @entity4 @entity0 , both in turbinate and in septal mucosa, total cell number and the number of basal cells did not change; however, the number of dome-shaped cells decreased and the number of ciliated and goblet cells increased in turbinate mucosa, and the number of ciliated cells decreased and the number of goblet cells increased in septal mucosa. In turbinate mucosa, the number of @entity6 (+) cells (mainly dome-shaped cells) decreased whereas the number of @entity5 (+) cells (mainly ciliated cells) increased. In septal mucosa, the number of @entity6 (+) and @entity5 (+) cells (mainly ciliated cells) decreased simultaneously. Intermediate phenotypic goblet cells could express @entity6 and @entity5 . @entity6 and @entity5 could be localized in the same cells. @entity1 reversed the changes of epithelium significantly. CONCLUSION: Allergen exposure leads to a possible transdifferentiation of @entity6 secreting cells into @entity5 secreting cells and/or goblet cells in upper airways. Nasal turbinate and septal epithelium display different patterns of transdifferentiation.

title: Transdifferentiation of Clara cell 10-kDa protein secreting cells in experimental XXXX .

answer: @entity4