abstract: INTRODUCTION: Although standard enteral nutrition is universally accepted, the use of disease-specific formulas for @entity7 @entity0 is still controversial. This study examines whether a high-protein @entity1 -specific formula reduces insulin needs, improves glycemic control and reduces ICU-acquired @entity4 in @entity8 , @entity7 @entity0 on mechanical ventilation (MV). METHODS: This was a prospective, open-label, randomized (web-based, blinded) study conducted at nine Spanish ICUs. The @entity0 groups established according to the high-protein formula received were: group A, new-generation @entity1 -specific formula; group B, standard control formula; group C, control @entity1 -specific formula. Inclusion criteria were: expected enteral nutrition >= 5 days, MV, baseline @entity6 >126 mg/dL on admission or >200 mg/dL in the first 48 h. Exclusion criteria were: APACHE II  <=10, @entity3 , treatment with @entity5 , immunosuppressants or lipid-lowering drugs and body mass index >= 40 kg/m(2). The targeted @entity6 level was 110-150 mg/dL. Glycemic variability was calculated as the standard deviation, glycemic lability index and coefficient of variation. Acquired @entity4 were recorded using published consensus criteria for @entity8 @entity0 . Data analysis was on an intention-to-treat basis. RESULTS: Over a 2-year period, 157 @entity0 were consecutively enrolled (A 52, B 53 and C 52). Compared with the standard control formula, the new formula gave rise to lower insulin requirement (19.1        13.1 vs. 23.7        40.1 IU/day, p <0.05), plasma @entity6 (138.6        39.1 vs. 146.1        49.9 mg/dL, p <0.01) and capillary blood @entity6 (146.1        45.8 vs. 155.3        63.6 mg/dL, p <0.001). Compared with the control @entity1 -specific formula, only capillary @entity6 levels were significantly reduced (146.1        45.8 vs. 150.1        41.9, p <0.01). Both specific formulas reduced capillary @entity6 on ICU day 1 (p <0.01), @entity6 variability in the first week (p <0.05), and incidences of ventilator-associated tracheobronchitis (p <0.01) or @entity2 (p <0.05) compared with the standard formula. No effects of the nutrition formula were produced on hospital stay or mortality. CONCLUSIONS: In these high-risk ICU @entity0 , both @entity1 lowered insulin requirements, improved glycemic control and reduced the risk of acquired @entity4 relative to the standard formula. Compared with the control-specific formula, the new-generation formula also improved capillary glycemia. TRIAL REGISTRATION: Clinicaltrials.gov NCT1233726 .

title: @entity1 -specific enteral nutrition formula in @entity7 , mechanically ventilated, @entity8 XXXX : a prospective, open-label, blind-randomized, multicenter study.

answer: @entity0


abstract: UNASSIGNED: Cardiac resynchronization therapy (CRT) has been shown to be effective for @entity2 . However, as outlined in the AHA/ACC/ @entity3 Appropriate Use Criteria, CRT is not strongly recommended for @entity0 with a narrow QRS complex. We describe a case of @entity1 and narrow QRS complex in which we obtained a dramatic response to CRT by optimizing the atrioventricular (AV) delay. The @entity0 was a 61-year-old @entity0 with intractable @entity2 . Echocardiography showed a low ejection fraction of 22% but no dyssynchrony. Because he had been hospitalized many times for @entity2 despite b-blocker and diuretic treatment, we decided to use CRT. However, after implantation of the CRT device, the QRS complex widened abnormally, and his symptoms worsened. He was re-admitted 2 months after CRT implantation. We examined the pacemaker status and optimized the AV delay to obtain a "narrow" QRS complex. The @entity0 's condition improved dramatically after the AV delay optimization. His clinical status has been good, and there has been no subsequent hospitalization. Our case points to the effectiveness of CRT in @entity0 with a narrow QRS complex and to the importance of AV optimization for successful CRT.

title: Dramatic Response to Cardiac Resynchronization Therapy With AV Delay Optimization in Narrow QRS XXXX .

answer: @entity2


abstract: OBJECTIVE: The diagnosis of small-sized (2 cm or less) @entity5 ( @entity5 ) has increased with the development of computed tomography (CT), whereas unexpected extensive multiple-level mediastinal involvement has been occasionally detected in this small-sized @entity1 . To establish the optimal surgical strategy, we retrospectively analyzed the clinicopathologic features, efficacy of preoperative investigations and lobe specific patterns of nodal spread in small-sized @entity5 with mediastinal involvement. METHODS: Among 1,550 resected @entity1 cases between 1981 and 2000, 267 (17.2%) had peripheral small-sized @entity5 . Of these, 29 @entity0 (10.8%) with mediastinal lymph node involvement who underwent pulmonary resection and systematic nodal dissection were reviewed. RESULTS: Among 29 @entity0 , 27 @entity0 (93.1%) were @entity4 , and 51.7% (15/29) showed no lymph node enlargement on CT (cN0). Surgical pathology revealed multiple-level mediastinal involvement in 65.5% (19/29) of all @entity0 and 60.0% (9/15) of cN0 @entity0 . All of @entity6 (n=11) showed multiple-level involvement. Thallium-201 single photon emission computed tomography (201Tl-SPECT) was positive for increased focal uptake in the mediastinum in 72.7% (8/11) of @entity0 . CONCLUSIONS: The vast majority of cases were @entity4 , and two thirds of them showed multiple-level mediastinal involvement, even in cN0 @entity0 . We thus recommend to perform systematic nodal dissection or meticulous sampling for accurate intrathoracic @entity3 , especially for @entity6 . 201Tl-SPECT appears to be more sensitive preoperative investigation for mediastinal @entity2 compared with CT scan.

title: Peripheral small-sized (2 cm or less) XXXX with mediastinal lymph node @entity2 ; clinicopathologic features and patterns of nodal spread.

answer: @entity5


abstract: OBJECTIVE: The diagnosis of small-sized (2 cm or less) @entity5 ( @entity5 ) has increased with the development of computed tomography (CT), whereas unexpected extensive multiple-level mediastinal involvement has been occasionally detected in this small-sized @entity1 . To establish the optimal surgical strategy, we retrospectively analyzed the clinicopathologic features, efficacy of preoperative investigations and lobe specific patterns of nodal spread in small-sized @entity5 with mediastinal involvement. METHODS: Among 1,550 resected @entity1 cases between 1981 and 2000, 267 (17.2%) had peripheral small-sized @entity5 . Of these, 29 @entity0 (10.8%) with mediastinal lymph node involvement who underwent pulmonary resection and systematic nodal dissection were reviewed. RESULTS: Among 29 @entity0 , 27 @entity0 (93.1%) were @entity4 , and 51.7% (15/29) showed no lymph node enlargement on CT (cN0). Surgical pathology revealed multiple-level mediastinal involvement in 65.5% (19/29) of all @entity0 and 60.0% (9/15) of cN0 @entity0 . All of @entity6 (n=11) showed multiple-level involvement. Thallium-201 single photon emission computed tomography (201Tl-SPECT) was positive for increased focal uptake in the mediastinum in 72.7% (8/11) of @entity0 . CONCLUSIONS: The vast majority of cases were @entity4 , and two thirds of them showed multiple-level mediastinal involvement, even in cN0 @entity0 . We thus recommend to perform systematic nodal dissection or meticulous sampling for accurate intrathoracic @entity3 , especially for @entity6 . 201Tl-SPECT appears to be more sensitive preoperative investigation for mediastinal @entity2 compared with CT scan.

title: Peripheral small-sized (2 cm or less) @entity5 with mediastinal lymph node XXXX ; clinicopathologic features and patterns of nodal spread.

answer: @entity2


abstract: Invasive monitoring of @entity1 ( @entity1 ) is becoming the standard of care for management of acute neurologic and neurosurgical @entity0 . As a result of improved fiber-optic technology, a new disposable 4 French @entity2 ( @entity2 ) has been introduced for facilitating measurement of @entity1 . Placement of the @entity2 can be intraventricular, subarachnoid, subdural, or intraparenchymal. Sensitivity and linearity of each catheter are manufacturer calibrated and not adjustable. Zero or atmospheric balance is done only once before insertion. Because the transducer is the catheter tip, no leveling to an anatomic point is necessary. The system appears to eliminate some of the difficulties inherent in fluid-filled catheter monitoring. In clinical trials, the comparison of @entity2 with subdural and ventriculostomy waveforms and pressures showed essentially no difference. Pressure recordings tracked well except during transient periods of @entity1 , when @entity2 showed higher peak pressures. Use of the @entity2 requires education regarding placement and maintenance techniques. Although staff experience with the catheter can practically eliminate the problem, the @entity2 catheters need special handling because of potential for fiber breakage.

title: Use of fiber-optic pressure transducer for XXXX measurements: a preliminary report.

answer: @entity1


abstract: In elderly @entity0 an unilateral @entity4 is frequently associated with a relatively more patent eustachian tube on the involved side. A simple method of investigation is observation under the operating microscope during tubal inflation by the @entity0 . In right-handed @entity0 the abnormally patent tube most often lay on the left side. Powerful self inflation in these @entity0 induces acute @entity3 and vertigo. Acute @entity3 is commoner on the left side. The air bone gap is greater at higher frequencies due to mobility of the stapes, loosening of the incudal joints and the tympanic membrane. In contrast the air bone gap is greater at lower frequencies in @entity6 or malleus head @entity5 . Minor degrees improve after self inflation is prohibited. In most @entity0 with abnormally patent eustachian tubes further therapy is not necessary after the @entity0 has received precise advice. In only about 20% of the cases is the @entity0 disturbed by a feeling of fullness in the ear, autophony and @entity2 . After stabilisation of weight and blood pressure, a septoplasty with correction of the posterior turbinates may reduce the exspiratory resistance. The most drastic treatment is a collagen injection around the tube. @entity0 with @entity1 should be treated appropriately.

title: [Unilateral patulous eustachian tube with XXXX , inner ear damage, vertigo and sudden deafness--collagen injection].

answer: @entity2


abstract: Neurophysiological studies of major @entity0 performed using PET imaging have shown abnormalities of regional cerebral blood flow (CBF) and @entity1 metabolism in multiple prefrontal cortical and limbic structures that have been more generally implicated in emotional processing. The current study investigated the effects of antidepressant drug treatment in these regions using PET measures of @entity1 metabolism. Subjects with primary @entity4 (n=27) were imaged while unmedicated and @entity0 , and, of these, 20 were rescanned following chronic antidepressant drug treatment. Regional metabolism was compared between unmedicated @entity0 and controls and between the pre- and post-treatment conditions in regions-of-interest (ROI) where metabolism or flow had previously been shown to be abnormal in unmedicated @entity0 . At baseline, the mean metabolism was increased in the left and right lateral orbital cortex/ventrolateral prefrontal cortex (PFC), left amygdala, and posterior cingulate cortex, and decreased in the subgenual ACC and dorsal medial/dorsal anterolateral PFC in the unmedicated @entity0 relative to controls, consistent with the results of previous studies. Following treatment, metabolism significantly decreased in the left amygdala and left subgenual ACC, and corresponding changes in the orbital and posterior cingulate cortices approached significance. The metabolic reduction in the amygdala and right subgenual ACC appeared largely limited to those subjects who both responded to treatment and remained well at 6 months follow-up, in whom the reduction in amygdala metabolism tightly correlated with the reduction in @entity3 scores. The magnitude of the treatment-associated, metabolic change in the amygdala also correlated positively with the change in the stressed plasma @entity2 levels measured during scanning. These data converge with those from other PET studies to indicate that primary @entity4 is associated with abnormal metabolism in limbic and paralimbic structures of the mesiotemporal and prefrontal cortices. Chronic antidepressant drug treatment reduces metabolism in the amygdala and ventral ACC in subjects showing a persistent, positive treatment response. In contrast, the persistence of the abnormal metabolic deficits in the dorsomedial/dorsal anterolateral PFC in @entity4 during treatment may conceivably relate to the histopathological changes reported in these regions in post mortem studies of @entity4 .

title: Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional XXXX metabolism.

answer: @entity1


abstract: We report a case of rabies acquired in Zambia by a 45-year-old @entity0 who presented with a history of an @entity2 , @entity3 and signs of @entity5 . A provisional @entity8 was made. Within 12 h of admission the @entity0 developed features of rabies that included @entity7 . She was artificially paralysed and ventilated electively. Empirical antibiotic therapy was given also. Signs of @entity5 and @entity1 disappeared within 48 h. Her clinical condition remained stable but she required heavy sedation. On the ninth day after admission the @entity0 developed features of inappropriate secretion of @entity6 and gradually became water-logged. Intake of fluid was therefore restricted. Her level of consciousness deteriorated progressively to the point where sedation was no longer required. @entity4 was diagnosed 14 days after admission.

title: Rabies presenting with XXXX and encephalitis.

answer: @entity5


abstract: BACKGROUND: @entity13 is a rare @entity3 characterized clinically by haematuria, @entity5 and @entity11 , and ultrastructurally by a lamellated @entity7 ( @entity7 ). It is usually caused by mutations in the @entity15 or @entity16 genes which code for the alpha3 and alpha4 chains of type IV collagen. We describe here a novel spontaneous model of @entity13 in Dalmatian @entity6 . METHODS: Affected @entity6 were identified by a urinary protein @entity9 >/=0.3. A total of 10 affected adult Dalmatians and eight unaffected age- and sex-matched @entity6 from breeds other than Dalmatians were examined. In addition, kidneys from five Dalmatian fetuses from affected mothers were examined histologically and ultrastructurally. RESULTS: All affected @entity6 were purebred Dalmatians and had a common progenitor. Successive generations were affected, and males and females were affected equally often and equally severely, consistent with autosomal dominant inheritance. The median age at onset of @entity5 was 18 months (range 8 months to 7 years). Affected @entity6 were not clinically deaf, and did not have the @entity8 seen in @entity0 X-linked or @entity14 . In addition, they did not have the leucocyte inclusions, low platelet counts or large platelets seen in autosomal dominant @entity12 due to @entity17 mutations. The renal histology and ultrastructural appearance of the @entity7 appeared to be normal in utero. However, affected adult kidneys demonstrated @entity1 and @entity10 with tubulo-interstitial @entity2 and @entity4 , and on ultrastructural examination the @entity7 was lamellated with subepithelial frilling, vacuolation and occasional intramembranous deposits. All alpha1(IV)-alpha5(IV) type IV collagen chains were present in the affected @entity7 and Bowman's capsule. CONCLUSIONS: @entity13 in Dalmatians resembles the disease in Bull terriers but has arisen independently. These models will enable us to determine how genetic mutations affect the corresponding proteins and overall membrane structure in @entity13 .

title: A novel model of XXXX in Dalmatian @entity6 .

answer: @entity13


abstract: BACKGROUND: @entity13 is a rare @entity3 characterized clinically by haematuria, @entity5 and @entity11 , and ultrastructurally by a lamellated @entity7 ( @entity7 ). It is usually caused by mutations in the @entity15 or @entity16 genes which code for the alpha3 and alpha4 chains of type IV collagen. We describe here a novel spontaneous model of @entity13 in Dalmatian @entity6 . METHODS: Affected @entity6 were identified by a urinary protein @entity9 >/=0.3. A total of 10 affected adult Dalmatians and eight unaffected age- and sex-matched @entity6 from breeds other than Dalmatians were examined. In addition, kidneys from five Dalmatian fetuses from affected mothers were examined histologically and ultrastructurally. RESULTS: All affected @entity6 were purebred Dalmatians and had a common progenitor. Successive generations were affected, and males and females were affected equally often and equally severely, consistent with autosomal dominant inheritance. The median age at onset of @entity5 was 18 months (range 8 months to 7 years). Affected @entity6 were not clinically deaf, and did not have the @entity8 seen in @entity0 X-linked or @entity14 . In addition, they did not have the leucocyte inclusions, low platelet counts or large platelets seen in autosomal dominant @entity12 due to @entity17 mutations. The renal histology and ultrastructural appearance of the @entity7 appeared to be normal in utero. However, affected adult kidneys demonstrated @entity1 and @entity10 with tubulo-interstitial @entity2 and @entity4 , and on ultrastructural examination the @entity7 was lamellated with subepithelial frilling, vacuolation and occasional intramembranous deposits. All alpha1(IV)-alpha5(IV) type IV collagen chains were present in the affected @entity7 and Bowman's capsule. CONCLUSIONS: @entity13 in Dalmatians resembles the disease in Bull terriers but has arisen independently. These models will enable us to determine how genetic mutations affect the corresponding proteins and overall membrane structure in @entity13 .

title: A novel model of @entity13 in Dalmatian XXXX .

answer: @entity6


abstract: In the course of a @entity1 (Malaysia comprises the Malaysian Peninsula, Sabah and Sarawak) during the period 1981-1986, more than 1000 isolates of Fusarium were obtained from diseased plants and seeds. Two further isolates were obtained from @entity0 admitted to hospitals in the same area. The occurrences of F. proliferatum, F. nygamai and F. longipes are new records for the Malaysian Peninsula and the association of @entity6 and @entity5 . redolens with @entity0 diseases does not seem to have been reported previously. Ten representative species which could be classified into seven sections of the genus were selected for studies of their toxigenicity in liquid cultures and/or on @entity4 . Crude toxin preparations from culture filtrates or extracts of the inoculated @entity4 were tested for @entity2 to brine shrimp larvae and @entity3 mesophyll protoplasts. The protoplasts were more sensitive than the brine shrimp larvae to the toxin preparations, except those from the isolates of @entity6 and @entity5 . redolens obtained from either @entity0 or @entity3 . The @entity2 of the preparations from @entity4 cultures per g @entity4 was always greater than the @entity2 per ml of culture filtrates from cultures grown on Czapek-Dox broth, Czapek-Dox supplemented with 1% (w/v) peptone or Czapek-Dox supplemented with 5% (w/v) tobacco extract. The activity of all toxin preparations was stable to heat. It is concluded that the occurrence of toxigenic species of Fusarium in the Malaysian Peninsula is widespread and that they may pose a serious threat to the health of @entity0 , animal and plant populations.

title: Toxigenicity of some fusaria associated with plant and @entity0 XXXX .

answer: @entity1


abstract: In the course of a @entity1 (Malaysia comprises the Malaysian Peninsula, Sabah and Sarawak) during the period 1981-1986, more than 1000 isolates of Fusarium were obtained from diseased plants and seeds. Two further isolates were obtained from @entity0 admitted to hospitals in the same area. The occurrences of F. proliferatum, F. nygamai and F. longipes are new records for the Malaysian Peninsula and the association of @entity6 and @entity5 . redolens with @entity0 diseases does not seem to have been reported previously. Ten representative species which could be classified into seven sections of the genus were selected for studies of their toxigenicity in liquid cultures and/or on @entity4 . Crude toxin preparations from culture filtrates or extracts of the inoculated @entity4 were tested for @entity2 to brine shrimp larvae and @entity3 mesophyll protoplasts. The protoplasts were more sensitive than the brine shrimp larvae to the toxin preparations, except those from the isolates of @entity6 and @entity5 . redolens obtained from either @entity0 or @entity3 . The @entity2 of the preparations from @entity4 cultures per g @entity4 was always greater than the @entity2 per ml of culture filtrates from cultures grown on Czapek-Dox broth, Czapek-Dox supplemented with 1% (w/v) peptone or Czapek-Dox supplemented with 5% (w/v) tobacco extract. The activity of all toxin preparations was stable to heat. It is concluded that the occurrence of toxigenic species of Fusarium in the Malaysian Peninsula is widespread and that they may pose a serious threat to the health of @entity0 , animal and plant populations.

title: Toxigenicity of some fusaria associated with plant and XXXX @entity1 .

answer: @entity0


abstract: @entity1 ( @entity0 ) or lean (L) primiparous gilts were assigned on the day of mating to an adequate [control (C) or restricted (R)] intake of feed. Body weight and ultrasonically estimated backfat depth were recorded at wk 0 (mating), 4, 8, 12 and 16 of pregnancy, and at d 2-3, 21 and 28 of lactation. Number of @entity3 born, survival rate to 28 d of age and piglet body weight at 0, 14, 21 and 28 d of age were recorded. Four male and four female progeny from each diet group of each @entity1 were slaughtered at 6 mo of age for carcass and organ weight measurements. OR and LR gilts responded similarly to feed restriction in body weight change, backfat depth and plasma traits. Body weight increased throughout gestation in OC and LC gilts but decreased about 6 kg in OR and LR gilts. Backfat remained relatively constant throughout gestation in OC and LC gilts but declined steadily in LR and OR gilts. There were no genetic group x diet interactions for any trait measured. Litter size and piglet survival were not affected by diet or genetic group, but piglet birth weight and daily gain to d 28 and to wk 25 were lower in both R groups. Backfat accretion and other indices of carcass @entity2 were reduced in progeny of R dams.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Comparative response of lean or genetically XXXX @entity3 and their progeny to severe feed restriction during gestation.

answer: @entity0


abstract: @entity1 ( @entity0 ) or lean (L) primiparous gilts were assigned on the day of mating to an adequate [control (C) or restricted (R)] intake of feed. Body weight and ultrasonically estimated backfat depth were recorded at wk 0 (mating), 4, 8, 12 and 16 of pregnancy, and at d 2-3, 21 and 28 of lactation. Number of @entity3 born, survival rate to 28 d of age and piglet body weight at 0, 14, 21 and 28 d of age were recorded. Four male and four female progeny from each diet group of each @entity1 were slaughtered at 6 mo of age for carcass and organ weight measurements. OR and LR gilts responded similarly to feed restriction in body weight change, backfat depth and plasma traits. Body weight increased throughout gestation in OC and LC gilts but decreased about 6 kg in OR and LR gilts. Backfat remained relatively constant throughout gestation in OC and LC gilts but declined steadily in LR and OR gilts. There were no genetic group x diet interactions for any trait measured. Litter size and piglet survival were not affected by diet or genetic group, but piglet birth weight and daily gain to d 28 and to wk 25 were lower in both R groups. Backfat accretion and other indices of carcass @entity2 were reduced in progeny of R dams.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Comparative response of lean or genetically @entity0 XXXX and their progeny to severe feed restriction during gestation.

answer: @entity3


abstract: @entity3 blockers may reduce contractility of vascular smooth muscle as well as that of myocardial cells. Therefore, falls in both total peripheral vascular resistance (TPR) and cardiac output (CO) might be responsible for a fall in blood pressure (BP) caused by @entity3 blockers in essential @entity2 . We have studied the acute and chronic haemodynamic effects of @entity6 (a new @entity3 blocker) in 19 @entity0 with essential @entity2 at rest in the supine and sitting positions and during 100-W dynamic exercise to investigate whether CO might be compromised by acute and chronic @entity3 blockade. Intra-arterial pressure, CO (by @entity5 ), @entity1 volume, heart rate and TPR were measured hourly after the first dose of 10 mg @entity6 (acute study) and then after 1 year of @entity6 treatment (mean dose 25 mg; chronic study). The maximal first dose response was seen after 1 h, i.e. a fall in intra-arterial pressure (9%) and TPR (19%) and a reflex rise in heart rate (9%) and CO (12%). The effects levelled off during the next 2 h. After 1 year of treatment there was a more marked reduction in BP: at rest intra-arterial pressure fell (14% supine, 16% sitting) due to fall in TPR (19%) but without significant changes in heart rate or CO; during 100-W exercise, intra-arterial pressure fell (14%) due to reduction in both TPR (7%) and CO (6%). In conclusion, @entity6 lowers BP by reducing TPR, both acutely and chronically. The initial reflex @entity4 and rise in CO disappear during long-term treatment, probably due to resetting of the baroreceptors.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity6 . Central haemodynamics at rest and during exercise in essential XXXX : acute and chronic studies.

answer: @entity2


abstract: @entity3 blockers may reduce contractility of vascular smooth muscle as well as that of myocardial cells. Therefore, falls in both total peripheral vascular resistance (TPR) and cardiac output (CO) might be responsible for a fall in blood pressure (BP) caused by @entity3 blockers in essential @entity2 . We have studied the acute and chronic haemodynamic effects of @entity6 (a new @entity3 blocker) in 19 @entity0 with essential @entity2 at rest in the supine and sitting positions and during 100-W dynamic exercise to investigate whether CO might be compromised by acute and chronic @entity3 blockade. Intra-arterial pressure, CO (by @entity5 ), @entity1 volume, heart rate and TPR were measured hourly after the first dose of 10 mg @entity6 (acute study) and then after 1 year of @entity6 treatment (mean dose 25 mg; chronic study). The maximal first dose response was seen after 1 h, i.e. a fall in intra-arterial pressure (9%) and TPR (19%) and a reflex rise in heart rate (9%) and CO (12%). The effects levelled off during the next 2 h. After 1 year of treatment there was a more marked reduction in BP: at rest intra-arterial pressure fell (14% supine, 16% sitting) due to fall in TPR (19%) but without significant changes in heart rate or CO; during 100-W exercise, intra-arterial pressure fell (14%) due to reduction in both TPR (7%) and CO (6%). In conclusion, @entity6 lowers BP by reducing TPR, both acutely and chronically. The initial reflex @entity4 and rise in CO disappear during long-term treatment, probably due to resetting of the baroreceptors.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX . Central haemodynamics at rest and during exercise in essential @entity2 : acute and chronic studies.

answer: @entity6


abstract: We report our experience using Sarmiento's method for the conservative treatment of 91 consecutive @entity2 of the lower leg. The mean age of the @entity0 in our series was 34 years. One @entity0 had an open @entity2 . All of the @entity0 were followed and were evaluated clinically and radiographically 6 to 12 months after injury. After a period of immobilization by traditional methods (traction/long leg cast), the Sarmiento brace was applied at a mean of 42 days, allowing early weightbearing and mobilization. The brace was removed at a mean of 90 days. Clinical results were excellent; there was minimal persistence of knee or ankle limitation; 84% of the @entity0 had less than 5 mm of final @entity3 ; 96% had less than 4 degrees of final angulation. Work was resumed at a mean of 103 days. We had one nonunion, which we treated operatively 6 months after injury by osteosynthesis and autologous bone grafting. All of the @entity0 were asked to complete a questionnaire; 51% responded, with an average followup of 5 years (range, 1 to 10 years). These @entity0 had been able to resume sports activity 8 months after injury; 52% were skiing 1 year after injury, and 96% were satisfied with the treatment method used. One @entity0 complained of persistent @entity1 .

title: Skiers' lower leg shaft XXXX . Outcome in 91 cases treated conservatively with Sarmiento's brace.

answer: @entity2


abstract: BACKGROUND _ AIMS: @entity5 ( @entity5 ) is regarded as a @entity1 . Few studies have looked for histopathologic changes in the gut and only then in biopsy specimens from intestinal mucosa. Because bowel function is governed mainly by nerve plexuses in the bowel wall, we have investigated full-thickness bowel biopsy specimens in @entity0 with severe @entity5 . METHODS: We used a laparoscopy-assisted technique to obtain full-thickness biopsy specimens from the proximal jejunum. Tissue specimens were investigated with light microscopy using routine stainings and immunohistochemical techniques. Horizontal sectioning was done to visualize large areas of the myenteric plexus. Fifteen autopsy specimens were used as controls regarding the myenteric plexus. @entity6 controls with terminal ileum biopsy specimens and full-thickness jejunal biopsy specimens from @entity0 with @entity3 were used as control groups for intraepithelial lymphocyte counts. RESULTS: Ten @entity0 (2 males, 8 females) were studied. In 9 @entity0 , we found low-grade infiltration of lymphocytes in the myenteric plexus. Lymphocytes had peri- and intraganglionic location. The mean number of lymphocytes per ganglion ranged from 1.9 to 7.1 per @entity0 , with an overall mean of 3.4. No intraganglionic lymphocytes were found in the control group and only a few periganglionic lymphocytes (mean, 0.2). Four @entity0 had concomitant intraepithelial lymphocytosis. @entity4 was evident in 6 of 9 @entity0 with and 1 @entity0 without ganglionic lymphocyte infiltration. CONCLUSIONS: Our findings indicate that @entity2 and @entity4 in the myenteric plexus are involved in the pathogenesis of @entity5 .

title: Full-thickness biopsy of the jejunum reveals @entity2 and enteric neuropathy in XXXX .

answer: @entity5


abstract: BACKGROUND _ AIMS: @entity5 ( @entity5 ) is regarded as a @entity1 . Few studies have looked for histopathologic changes in the gut and only then in biopsy specimens from intestinal mucosa. Because bowel function is governed mainly by nerve plexuses in the bowel wall, we have investigated full-thickness bowel biopsy specimens in @entity0 with severe @entity5 . METHODS: We used a laparoscopy-assisted technique to obtain full-thickness biopsy specimens from the proximal jejunum. Tissue specimens were investigated with light microscopy using routine stainings and immunohistochemical techniques. Horizontal sectioning was done to visualize large areas of the myenteric plexus. Fifteen autopsy specimens were used as controls regarding the myenteric plexus. @entity6 controls with terminal ileum biopsy specimens and full-thickness jejunal biopsy specimens from @entity0 with @entity3 were used as control groups for intraepithelial lymphocyte counts. RESULTS: Ten @entity0 (2 males, 8 females) were studied. In 9 @entity0 , we found low-grade infiltration of lymphocytes in the myenteric plexus. Lymphocytes had peri- and intraganglionic location. The mean number of lymphocytes per ganglion ranged from 1.9 to 7.1 per @entity0 , with an overall mean of 3.4. No intraganglionic lymphocytes were found in the control group and only a few periganglionic lymphocytes (mean, 0.2). Four @entity0 had concomitant intraepithelial lymphocytosis. @entity4 was evident in 6 of 9 @entity0 with and 1 @entity0 without ganglionic lymphocyte infiltration. CONCLUSIONS: Our findings indicate that @entity2 and @entity4 in the myenteric plexus are involved in the pathogenesis of @entity5 .

title: Full-thickness biopsy of the jejunum reveals XXXX and enteric neuropathy in @entity5 .

answer: @entity2


abstract: The association of @entity5 and @entity6 was observed in three @entity0 , an association not previously reported. All three @entity0 were @entity0 who presented with chronic @entity4 at ages 32, 46, and 62 years, respectively. In each @entity0 , endoscopic retrograde cholangiography showed the typical findings of @entity5 . Histologic features of liver biopsy were compatible with the diagnosis. Two @entity0 had associated chronic @entity1 . All three @entity0 complained of frequent loose stools and @entity3 ; subsequent testing showed severe @entity7 (204 to 323 mmol/d of fecal fat on a 100 g fat diet). @entity2 was found in all three @entity0 on histologic examination of the small bowel. @entity6 was diagnosed at the time of presentation in two @entity0 who had @entity5 and was diagnosed three years after the onset of @entity5 in the third @entity0 . The @entity6 responded to a gluten-free diet in each @entity0 whereas the @entity5 was not affected by dietary treatment. The possibility of a chance association of @entity5 and @entity6 cannot be accurately assessed but seems unlikely given the rarity of both diseases. The relationship between the two diseases remains unknown, although an immunologic connection is suspected. @entity6 should be considered in the differential diagnosis of severe @entity7 in @entity0 with @entity5 .

title: XXXX and @entity6 . A novel association.

answer: @entity5


abstract: The association of @entity5 and @entity6 was observed in three @entity0 , an association not previously reported. All three @entity0 were @entity0 who presented with chronic @entity4 at ages 32, 46, and 62 years, respectively. In each @entity0 , endoscopic retrograde cholangiography showed the typical findings of @entity5 . Histologic features of liver biopsy were compatible with the diagnosis. Two @entity0 had associated chronic @entity1 . All three @entity0 complained of frequent loose stools and @entity3 ; subsequent testing showed severe @entity7 (204 to 323 mmol/d of fecal fat on a 100 g fat diet). @entity2 was found in all three @entity0 on histologic examination of the small bowel. @entity6 was diagnosed at the time of presentation in two @entity0 who had @entity5 and was diagnosed three years after the onset of @entity5 in the third @entity0 . The @entity6 responded to a gluten-free diet in each @entity0 whereas the @entity5 was not affected by dietary treatment. The possibility of a chance association of @entity5 and @entity6 cannot be accurately assessed but seems unlikely given the rarity of both diseases. The relationship between the two diseases remains unknown, although an immunologic connection is suspected. @entity6 should be considered in the differential diagnosis of severe @entity7 in @entity0 with @entity5 .

title: @entity5 and XXXX . A novel association.

answer: @entity6


abstract: OBJECTIVE: To study the incidence, clinical presentation and pathological prognostic factors affecting disease outcome of @entity4 in young adults less than 40 years old. METHODS: The charts o medical records of 400 @entity0 treated surgically for @entity4 between January 1984 and December 1999 were reviewed. 29 (7.25%) @entity0 were under 40. We used ANOVA regression and Chisquare (Fisher exact test) to assess the prognostic value of the quantitative and qualitative variables, respectively. Estimation of the survival distributions were calculated according to Kaplan-Meier method and compared with Log rank test. Multivariate analysis of the entire population utilizing Cox models was performed. RESULTS: The most common histological cell type was @entity4 , found in 20 (69%) @entity0 . At a median follow-up of 80 months, 20 (69%) @entity0 were disease free and 9 (31%) died of the disease. Incidental discovery (p = 0.05), @entity2 stage (p = 0.043), grade (p = 0.011), lymphatic invasion (p < 0.0001) @entity1 (p = 0.003), adrenal invasion (p = 0.024), and @entity3 (p < 0.0001) were associated with prognosis (Kaplan-Meier). When comparing @entity0 less than 40 years vs. older than 40 years, we found significant differences in histology type ( @entity4 69% vs. 91%; p = 0.0001), and @entity2 stage at presentation (pT2 = 34.5% vs. 17.3%; p = 0.04) ( @entity5 = 20.7% vs. 42%; p = 0.03). Disease free survival was not significantly different between the two groups (69% vs. 65.7%; Log rank test p = 0.4). CONCLUSION: Although rare, @entity4 in young adults seems to follow a course similar to the disease seen in older @entity0 . Among the prognostic factors studied incidental discovery, pathological stage of the @entity2 and grade, were associated with survival. Stage at presentation was different between the two populations however survival was not affected by age.

title: XXXX in young adults: incidence, disease outcome and review of the literature.

answer: @entity4


abstract: BACKGROUND: Cautious exploration of the safety of home treatment of @entity1 has been recommended by many. Our goal was to identify categories of @entity0 with @entity1 who typically are hospitalized, and categories frequently treated at home. METHODS: The Nationwide Emergency Department Sample and the Nationwide Inpatient Sample, 2007-2012, were used to determine the number of @entity0 seen in emergency departments throughout the US with @entity1 and no diagnosis of @entity2 , the proportion of such @entity0 hospitalized according to comorbid conditions and age, the proportion discharged early ( <=2 days), and charges for hospitalization and emergency department visits. RESULTS: From 2007-2012, home treatment was selected for 905,152 of 2,671,452 (33.9%) @entity0 with @entity1 . Home treatment was more frequent in those with no comorbid conditions than with comorbid conditions, 58.0% compared with 15.5% (P <.0001). Early discharge ( <=2 days) was in 23.9% with no comorbid conditions, compared with 12.8% with comorbid conditions. Among @entity0 aged 18-50 years, home treatment was selected in 62.9% with no comorbid conditions, compared with 24.2% with comorbid conditions (P <.0001). Among hospitalized @entity0 with no comorbid conditions, 40.7% were aged 18-50 years. Their charges for hospitalization in 2012 were  494 million. CONCLUSION: @entity0 aged 50 years or younger with @entity1 and no comorbid conditions appear to be a group that can be targeted for more frequent home treatment, which would save millions of dollars.

title: Home Treatment of XXXX According to Comorbid Conditions.

answer: @entity1


abstract: Intracerebral @entity3 , especially in the basal ganglia, are observed in many kinds of diseases. A 41-year-old @entity0 is reported, who suffered from an acute epidural @entity4 and underwent surgery to remove the @entity4 . We detected very extensive intracerebral calcification on CT. Laboratory findings revealed @entity6 and @entity5 . General physical examination revealed characteristics typical of @entity7 . The @entity0 was diagnosed as having @entity7 type I by the Ellsworth-Howard test. Since the advent of CT, the incidence of @entity8 has increased. CT is 5 to 15 times more sensitive than skull radiography in the detection of intracerebral calcification. Although many pathological states can cause @entity8 , most of the @entity3 which are recognized on CT scans are physiological. But in cases in which @entity8 are recognized also on plain radiographs, various kinds of symptoms including ones of basal ganglia origin are often recognized, and @entity3 often extend to regions other than basal ganglia, eg. cerebellum, thalamus, etc. @entity7 is a @entity2 which presents @entity6 , some characteristic physical appearances, and @entity1 . It is important to decide whether further examinations are necessary or not, when @entity8 is recognized incidentally on CT scan.

title: [A case of XXXX with intracerebral calcification].

answer: @entity7


abstract: A 53-year-old female with @entity6 associated with bilateral @entity7 was reported. She was admitted because of numbness in the bilateral feet and gait disturbance. Her parents were not related. There was no family history of any @entity0 . She had bilateral @entity7 which were present at birth to developed in early childhood. She could walk, but could not run. Since 5 years prior to the admission she noted gradually increasing disturbance of gait. Neurological examination revealed @entity2 and @entity8 in the distal parts of the lower extremities and @entity3 . There were @entity5 , hypalgesia and @entity4 in the lateral portions of the bilateral feet. Deep sensation was normal. There was no weakness or @entity8 in the upper extremities. Motor nerve conduction velocities were normal and sensory nerve conduction velocities were reduced in the median nerve. No action potentials could not be elicited in the bilateral tibial and peroneal nerves. A sural nerve biopsy showed a markedly hypertrophic perineurium, 28-150 micron thick, a large Renaut body measured 140 micron by 200 micron in diameters and a markedly reduced number of the myelinated fibers. Fiber size histogram showed many unmyelinated fibers larger than 1 micron, despite loss of fibers of the usual size. Therefore, a part of the unmyelinated fibers might be demyelinated. There were no axonal degeneration and onion-bulb formation. @entity1 was found in approximately 30% of the myelinated fibers.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ @entity6 associated with congenital bilateral XXXX : histological and ultrastructural study of the sural nerve].

answer: @entity7


abstract: A 53-year-old female with @entity6 associated with bilateral @entity7 was reported. She was admitted because of numbness in the bilateral feet and gait disturbance. Her parents were not related. There was no family history of any @entity0 . She had bilateral @entity7 which were present at birth to developed in early childhood. She could walk, but could not run. Since 5 years prior to the admission she noted gradually increasing disturbance of gait. Neurological examination revealed @entity2 and @entity8 in the distal parts of the lower extremities and @entity3 . There were @entity5 , hypalgesia and @entity4 in the lateral portions of the bilateral feet. Deep sensation was normal. There was no weakness or @entity8 in the upper extremities. Motor nerve conduction velocities were normal and sensory nerve conduction velocities were reduced in the median nerve. No action potentials could not be elicited in the bilateral tibial and peroneal nerves. A sural nerve biopsy showed a markedly hypertrophic perineurium, 28-150 micron thick, a large Renaut body measured 140 micron by 200 micron in diameters and a markedly reduced number of the myelinated fibers. Fiber size histogram showed many unmyelinated fibers larger than 1 micron, despite loss of fibers of the usual size. Therefore, a part of the unmyelinated fibers might be demyelinated. There were no axonal degeneration and onion-bulb formation. @entity1 was found in approximately 30% of the myelinated fibers.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ XXXX associated with congenital bilateral @entity7 : histological and ultrastructural study of the sural nerve].

answer: @entity6


abstract: @entity2 ) is a leading cause of @entity1 that can result in serious disabilities in affected @entity0 . To facilitate HCMV vaccine development, a microscale neutralization assay based on reverse transcription quantitative PCR (RT-qPCR) was developed to quantify HCMV-neutralizing antibodies. Our approach relies on the generation of crude lysates from virus-infected cells that are amenable to direct analysis by RT-qPCR, thereby circumventing rate-limiting procedures associated with sample RNA extraction and purification. By serial passaging of the laboratory HCMV strain AD169 in epithelial cells (ARPE-19), a revertant virus with restored epithelial cell tropism, designated AD169(wt131), was obtained. AD169 and AD169(wt131) were evaluated in both epithelial cells (ARPE-19) and fibroblasts (MRC-5) by one-step RT-qPCR targeting the immediate-early gene IE1 transcript of HCMV. Expression kinetics indicated that RT-qPCR assessment could be conducted as early as 6h post-infection. Human serum samples (n=30) from healthy donors were tested for HCMV-specific IgG using a commercially available ELISA and for HCMV-neutralizing activity using our RT-qPCR-based neutralization assay. In agreement with the ELISA results, higher neutralizing activity was observed in the HCMV IgG seropositive group when compared with the HCMV IgG seronegative group. In addition, HCMV IgG seropositive @entity0 sera exhibited higher neutralizing titers using epithelial cells compared with using fibroblasts (geometric mean titers of 344 and 8 in @entity0 cells and MRC-5 cells, respectively). Our assay was robust to variation in input virus dose. In addition, a simple lysis buffer containing a non-ionic detergent was successfully demonstrated to be a less costly alternative to commercial reagents for cell-lysate preparation. Thus, our rapid HCMV neutralization assay may be a straightforward and flexible high-throughput tool for measuring antibody responses induced by vaccination and @entity1 .

title: RT-qPCR-based microneutralization assay for XXXX using fibroblasts and epithelial cells.

answer: @entity2


abstract: True @entity1 and spleen are uncommon and it has been recommended that laparoscopic management is appropriate. Often these cysts are large and centrally located by the time they reach clinical significance thereby making complete excision difficult without major liver resection or splenectomy. Definitive therapy consists of drainage and complete resection of the cyst wall. Three @entity0 presented with upper @entity2 . Workup revealed large non-parasitic true @entity1 (one) and spleen (two). All were initially treated with laparoscopic resection of their cysts with the primary objective being organ preservation. They were followed with periodic ultrasound/CT scanning. The pathology report in all three cases demonstrated benign congenital epithelial cysts and the @entity0 did well postoperatively. Despite meticulous dissection and marsupialization of the cysts all three @entity0 experienced recurrence that necessitated further therapy. We conclude that laparoscopic surgery is inadequate in the management of true @entity1 and spleen unless complete removal of all cyst wall can be assured.

title: Laparoscopic treatment of large true XXXX and spleen is ineffective.

answer: @entity1


abstract: Perturbation of origin firing in chromosome replication is a possible cause of spontaneous chromosome instability in multireplicon organisms. Here, we show that @entity2 , including aneuploidy and chromosome rearrangement, were significantly increased in @entity0 diploid cells with defects in the origin recognition complex. The cell cycle of @entity4 -4/ @entity4 -4 temperature-sensitive mutant was arrested at the G2/M boundary, after several rounds of cell division at the restrictive temperature. However, prolonged incubation of the mutant cells at 37 degrees C led to abrogation of @entity1 , and simultaneously the cells started to lose viability. A sharp increase in chromosome instability followed the abrogation of @entity1 . In @entity4 -4/ @entity4 -4 rad9delta/rad9delta diploid cells grown at 37 degrees C, @entity1 and induction of cell death were suppressed, while chromosome instability was synergistically augmented. These findings indicated that DNA lesions caused by a defect in @entity4 function trigger the @entity3 -dependent checkpoint control, which ensures genomic integrity either by stopping the cell cycle progress until lesion repair, or by inducing cell death when the lesion is not properly repaired. At semirestrictive temperatures, @entity5 -1/ @entity5 -1 diploid cells demonstrated @entity1 and loss of cell viability, both of which require @entity3 -dependent checkpoint control. However, chromosome instability was not induced in @entity5 -1/ @entity5 -1 cells, even in the absence of the checkpoint control. These data suggest that once cells lose the damage checkpoint control, perturbation of origin firing can be tolerated by the cells. Furthermore, although a reduction in origin-firing capacity does not necessarily initiate chromosome instability, the @entity4 possesses a unique function, the loss of which induces instability in the chromosome.

title: Involvement of XXXX -dependent damage checkpoint control in arrest of cell cycle, induction of cell death, and chromosome instability caused by defects in origin recognition complex in @entity0 .

answer: @entity3


abstract: Perturbation of origin firing in chromosome replication is a possible cause of spontaneous chromosome instability in multireplicon organisms. Here, we show that @entity2 , including aneuploidy and chromosome rearrangement, were significantly increased in @entity0 diploid cells with defects in the origin recognition complex. The cell cycle of @entity4 -4/ @entity4 -4 temperature-sensitive mutant was arrested at the G2/M boundary, after several rounds of cell division at the restrictive temperature. However, prolonged incubation of the mutant cells at 37 degrees C led to abrogation of @entity1 , and simultaneously the cells started to lose viability. A sharp increase in chromosome instability followed the abrogation of @entity1 . In @entity4 -4/ @entity4 -4 rad9delta/rad9delta diploid cells grown at 37 degrees C, @entity1 and induction of cell death were suppressed, while chromosome instability was synergistically augmented. These findings indicated that DNA lesions caused by a defect in @entity4 function trigger the @entity3 -dependent checkpoint control, which ensures genomic integrity either by stopping the cell cycle progress until lesion repair, or by inducing cell death when the lesion is not properly repaired. At semirestrictive temperatures, @entity5 -1/ @entity5 -1 diploid cells demonstrated @entity1 and loss of cell viability, both of which require @entity3 -dependent checkpoint control. However, chromosome instability was not induced in @entity5 -1/ @entity5 -1 cells, even in the absence of the checkpoint control. These data suggest that once cells lose the damage checkpoint control, perturbation of origin firing can be tolerated by the cells. Furthermore, although a reduction in origin-firing capacity does not necessarily initiate chromosome instability, the @entity4 possesses a unique function, the loss of which induces instability in the chromosome.

title: Involvement of @entity3 -dependent damage checkpoint control in arrest of cell cycle, induction of cell death, and chromosome instability caused by defects in origin recognition complex in XXXX .

answer: @entity0


abstract: Subcapsular or perirenal @entity2 is the most commonly experienced adverse effect directly attributable to externally applied shock waves. The first consecutive 3,620 extracorporeal shock wave lithotripsy treatments with the @entity4 Dornier lithotriptor at our institution resulted in 24 @entity3 in 21 @entity0 , for an incidence of 0.66 per cent. Various factors associated with treatment were examined. The number of shock waves (up to 2,000) and voltage up to 24 kv. did not correlate with the development of @entity3 . Coagulation studies were normal in all @entity0 with @entity3 . There was no correlation of @entity0 size and weight, or stone size, number or location with the occurrence rate of perinephric @entity3 . @entity0 with pre-existing @entity1 , particularly those with unsatisfactory control of @entity1 , had a significantly increased incidence of perinephric @entity3 . The incidence of @entity3 in @entity1 @entity0 was 2.5 per cent and it increased to 3.8 per cent in @entity0 with unsatisfactory control of @entity1 . Therefore, pre-existing @entity1 is a significant risk factor in the occurrence of post-extracorporeal shock wave lithotripsy @entity2 . The incidence of perinephric @entity3 also was increased in @entity0 with pre-treatment urinary tract infection and those who underwent simultaneous bilateral treatment. Management of post-extracorporeal shock wave lithotripsy @entity2 generally is conservative although a third of the @entity0 required transfusion.

title: Extracorporeal shock wave lithotripsy-induced perirenal XXXX .

answer: @entity3


abstract: BACKGROUND: This study is a component of a large research project on five major @entity2 ( @entity2 ) including @entity3 and was undertaken in the Province of Sidi Kacem over a period of four years (April 2009-March 2013). METHODS: Questionnaires were administered at community level in a total of 27 communes and visits were made to all of the 10 abattoirs situated in the Province, to collect qualitative data on determinants of transmission for disease in @entity0 and animals. More specifically, community knowledge, attitudes and practices related to @entity3 were assessed, as well as the extent to which local customs and behaviours may promote transmission. Abattoir infrastructure and practices, and their role in perpetuating disease transmission were also critically evaluated. RESULTS: The results show that only 50  % of @entity0 have heard of the disease, and of those, only 21  % are aware of the @entity1 's role in disease transmission. Sixty-seven per cent of respondents stated that @entity1 are fed ruminant organs deemed unfit for @entity0 consumption. Owned @entity1 have access to the family home, including the kitchen, in 39  % of households. The extent of this close proximity between @entity0 and animals is even more pertinent when one considers that @entity1 are omnipresent in the community, with an average of 1.8 @entity1 owned per household. The unrestricted access of @entity1 to abattoirs is a huge issue, which further promotes disease transmission. CONCLUSION: This study would suggest that the high prevalence of @entity3 in @entity0 and animals in Morocco is largely due to three factors: 1) abundance of @entity1 2) engagement in risky behaviour of the local population and 3) poor abattoir infrastructure and practices. This has serious implications in terms of the socio-economic impact of the disease, especially for rural poor communities.

title: Knowledge, attitudes and practices with regard to the presence, transmission, impact, and control of XXXX in Sidi Kacem Province, Morocco.

answer: @entity3


abstract: UNASSIGNED: An efficient and robust method to measure @entity1 ( @entity3 ( @entity2 ) and @entity4 in dried blood spots (DBS) has been developed and applied in the pan-European multi-centre, internet-based, personalised nutrition intervention study Food4Me. The method includes calibration with blood containing endogenous @entity2 , spotted as DBS and corrected for haematocrit content. The methodology was validated following international standards. The performance characteristics did not reach those of the current gold standard liquid chromatography-MS/MS in plasma for all parameters, but were found to be very suitable for status-level determination under field conditions. DBS sample quality was very high, and 3778 measurements of @entity2 were obtained from 1465 @entity0 . The study centre and the season within the study centre were very good predictors of @entity2 levels (P<0  001 for each case). Seasonal effects were modelled by fitting a sine function with a minimum @entity2 level on 20 January and a maximum on 21 July. The seasonal amplitude varied from centre to centre. The largest difference between winter and summer levels was found in Germany and the smallest in Poland. The model was cross-validated to determine the consistency of the predictions and the performance of the DBS method. The Pearson's correlation between the measured values and the predicted values was r 0  65, and the sd of their differences was 21  2 nmol/l. This includes the analytical variation and the biological variation within subjects. Overall, DBS obtained by unsupervised sampling of the @entity0 at home was a viable methodology for obtaining @entity1 status information in a large nutritional study.

title: Application of dried blood spots to determine XXXX status in a large nutritional study with unsupervised sampling: the Food4Me project.

answer: @entity1


abstract: Phycocyanin is a phycobiliprotein with peak absorption at 620 nm. The laser activation, cytotoxic effects, and uptake into @entity2 of phycocyanin was studied. Optimal activation was produced by @entity5 dye laser at 0.5 W and a total energy dose of 300 J/cm2 at 620 nm and 650 nm, irradiated through blood with a hematocrit of 8%. Activation was evidenced by reduction of optical density by 0.3 units at 340 nm caused by oxidation of the reduced @entity3 ( @entity3 ) in a buffered reaction solution containing 0.1 mg/ml of phycocyanin. @entity1 was evaluated by measuring viability of @entity0 @entity4 cells in culture after incubation with phycocyanin (0.25 mg/ml) and irradiated by 300 J/cm2 at 514 nm. After 72 hours post-treatment the cells showed 15% viability compared to 69% and 71% for control cells exposed to laser only or phycocyanin only, respectively. Atherosclerotic artery segments obtained within 5 hours postmortem were perfused with 0.1 mg/ml phycocyanin in oxygenated Krebs Ringer solution at 30 mm Hg for 5 minutes followed by washout with phycocyanin-free Krebs for 10 minutes. Artery sections examined histologically by light and fluorescence microscopy showed specific fluorescence localization within the plaque particularly at the elastic laminae and to a larger extent at the internal elastic lamina but not in the medial muscle layer. In conclusion, phycocyanin is a cytotoxic photosensitizer that exhibits specific binding to plaque and is activated at a wavelength minimally absorbed by blood. These properties suggest potential therapeutic use for plaque localization and regression.

title: Phycocyanin: laser activation, cytotoxic effects, and uptake in human XXXX .

answer: @entity2


abstract: PURPOSE: The @entity8 is an @entity2 consisting of the triad of oculocutaneous albinism, a storage pool @entity4 , and multisystem tissue deposition of ceroid pigment. Although the underlying metabolic defect has not been identified, secondary or associated effects on the immune system are suggested by reports of an association with disorders such as @entity6 , @entity1 , lupus, and frequent @entity5 . We evaluated a large group of @entity0 with the @entity8 to assess immune competence in this condition. @entity0 AND METHODS: Fifteen @entity0 with this syndrome were studied. Control subjects included healthy volunteers in the same age range as the @entity0 . Peripheral blood lymphocytes and neutrophils were isolated according to previously described methods. Immunofluorescent staining, flow cytometry, and @entity3 assays were performed. Determination of lymphocyte transformation, mixed lymphocyte response, and neutrophil function was made. RESULTS: Immunoglobulin levels, complement, lymphocyte subsets, natural killer and lymphokine-activated @entity3 , mixed lymphocyte responses, and lectin-induced transformation were normal in all @entity0 . In addition, there was no evidence for a lymphocyte proliferative response to a preparation of urinary @entity9 pigment isolated from these @entity0 . Neutrophil function, including @entity7 -dependent chemiluminescence, chemotaxis, and aggregation was not significantly different from control values. CONCLUSION: The results suggest that there is no generalized defect of peripheral blood lymphocyte or neutrophil function in the @entity8 . We propose that future studies should examine the possibility that associated disorders arise from a defect within the monocyte-macrophage system, perhaps secondary to ceroid accumulation.

title: XXXX : an immunologic assessment of 15 cases.

answer: @entity8


abstract: STUDY OBJECTIVE: To determine the prevalence of @entity2 in @entity0 with mild asymptomatic @entity3 and to ascertain whether this prevalence is increased in comparison with the rate in a retrospective control group previously studied at the same institution or with current estimates of the risk for @entity2 in subjects of similar age. DESIGN: Prospectively collected data were retrospectively analyzed and compared with data from a historical control group at the same institution and with published data. SETTING: The outpatient department of a bone and mineral metabolism clinic. @entity0 : A consecutive series of @entity0 with mild asymptomatic @entity3 diagnosed between 1 January 1976 and 31 December 1985. Criteria for inclusion in the study were the absence of symptoms due to @entity7 , no current @entity1 , no radiographic evidence of @entity8 , a serum @entity4 level of less than 3.00 mmol/L, a serum @entity6 level of less than 133 mumol/L, and a forearm bone density value not more than 2.5 standard deviations below the age-, sex-, and race-adjusted normal value. INTERVENTIONS: A conservative nonintervention study. MEASUREMENTS AND MAIN RESULTS: The prevalence of @entity2 in 174 @entity0 (mean age, 62 years) with mild asymptomatic @entity3 was 1.7%; in a subset of white @entity0 , the prevalence was 2.8%. These rates were not higher than those expected, by comparison with the rate in a retrospective control group or with the risk for @entity2 in subjects of similar age, and may even be lower. CONCLUSIONS: The risk for @entity2 is not increased in @entity0 with mild asymptomatic @entity3 and is not a reason to recommend surgical intervention in asymptomatic @entity0 . The increased rates of @entity2 that occurred in other series are probably due to the use of inappropriate controls and the influence of referral or selection bias, the inclusion of @entity0 with severer disease, and the effect of geographic differences in @entity5 nutrition on the expression of disease. Possible differences between lateral spine and lateral chest radiographs for determining vertebral body shape need further study.

title: Mild asymptomatic XXXX is not a risk factor for @entity2 .

answer: @entity3


abstract: STUDY OBJECTIVE: To determine the prevalence of @entity2 in @entity0 with mild asymptomatic @entity3 and to ascertain whether this prevalence is increased in comparison with the rate in a retrospective control group previously studied at the same institution or with current estimates of the risk for @entity2 in subjects of similar age. DESIGN: Prospectively collected data were retrospectively analyzed and compared with data from a historical control group at the same institution and with published data. SETTING: The outpatient department of a bone and mineral metabolism clinic. @entity0 : A consecutive series of @entity0 with mild asymptomatic @entity3 diagnosed between 1 January 1976 and 31 December 1985. Criteria for inclusion in the study were the absence of symptoms due to @entity7 , no current @entity1 , no radiographic evidence of @entity8 , a serum @entity4 level of less than 3.00 mmol/L, a serum @entity6 level of less than 133 mumol/L, and a forearm bone density value not more than 2.5 standard deviations below the age-, sex-, and race-adjusted normal value. INTERVENTIONS: A conservative nonintervention study. MEASUREMENTS AND MAIN RESULTS: The prevalence of @entity2 in 174 @entity0 (mean age, 62 years) with mild asymptomatic @entity3 was 1.7%; in a subset of white @entity0 , the prevalence was 2.8%. These rates were not higher than those expected, by comparison with the rate in a retrospective control group or with the risk for @entity2 in subjects of similar age, and may even be lower. CONCLUSIONS: The risk for @entity2 is not increased in @entity0 with mild asymptomatic @entity3 and is not a reason to recommend surgical intervention in asymptomatic @entity0 . The increased rates of @entity2 that occurred in other series are probably due to the use of inappropriate controls and the influence of referral or selection bias, the inclusion of @entity0 with severer disease, and the effect of geographic differences in @entity5 nutrition on the expression of disease. Possible differences between lateral spine and lateral chest radiographs for determining vertebral body shape need further study.

title: Mild asymptomatic @entity3 is not a risk factor for XXXX .

answer: @entity2


abstract: BACKGROUND AND OBJECTIVE: The platinum-containing combination chemotherapy has been proved to be benefit to the @entity0 with advanced @entity5 . Compared with cisplatin-based combination chemotherapy regimens, carboplatin-based regimens result in longer survival time and less @entity2 , despite of lower response rate. In the palliative treatment setting, less @entity2 and longer survival may be more significant than response rate. So we choose the carboplatin-based combination chemotherapy regimens as our study objects. To compare the efficacy and @entity2 of two carboplatin-based combination chemotherapy regimens: paclitaxel and carboplatin regimen(PC) vs ifosfamide, etoposide, and carboplatin regimen(IEC). METHODS: Sixty-eight @entity0 were enrolled in this study, 35 @entity0 received PC regimen and 33 received IEC regimen. @entity0 in both groups were well-matched with baseline disease characteristics(P > 0.05). RESULTS: In PC group, the response rate was 40.0% (14/35, 95% confidence interval [CI]: 23.8%-56.2%) (14 PR, 19 NC, 2 @entity7 ). Whereas in group IEC, the response rate was 21.2% (7/33, 95% CI: 7.3%-35.1%) (7 PR, 24 NC, 2 @entity7 ). The median survival and 1-year survival rate were 9.1 months (95% CI: 7.2-11.0 months) and 25.7% (95% CI: 11.2%-40.2%) for group PC versus 7.8 months (95% CI: 6.2-9.4 months) and 20.0% (95% CI: 6.0%-34.0%) for group IEC. The better response rate, 1-year survival rate, and the longer median survival seen in the group PC were not statistically significant (for response rate, P = 0.094, Chi-square test; for overall survival, P = 0.684, Log-rank test). The hematologic @entity2 , especially @entity6 (P < 0.0005, Wilcoxon rank sum test) and @entity3 (P = 0.006, Wilcoxon rank sum test) were less pronounced in group PC; @entity4 and fever were pronounced more in group IEC, whereas @entity1 was more in group PC, but there were no statistically significant differences between the two groups(P > 0.05, Wilcoxon rank sum test); Other @entity2 were similar. CONCLUSIONS: Compared with IEC regimen, PC regimen result in less hematologic @entity2 in the @entity0 with advanced NSCLC, Although whether its efficacy was better should be confirmed by well-controlled randomized clinical trials with more @entity0 .

title: [Comparison of paclitaxel and carboplatin versus ifosfamide, etoposide, and carboplatin regimen for treatment of @entity0 with advanced XXXX ].

answer: @entity5


abstract: BACKGROUND AND OBJECTIVE: The platinum-containing combination chemotherapy has been proved to be benefit to the @entity0 with advanced @entity5 . Compared with cisplatin-based combination chemotherapy regimens, carboplatin-based regimens result in longer survival time and less @entity2 , despite of lower response rate. In the palliative treatment setting, less @entity2 and longer survival may be more significant than response rate. So we choose the carboplatin-based combination chemotherapy regimens as our study objects. To compare the efficacy and @entity2 of two carboplatin-based combination chemotherapy regimens: paclitaxel and carboplatin regimen(PC) vs ifosfamide, etoposide, and carboplatin regimen(IEC). METHODS: Sixty-eight @entity0 were enrolled in this study, 35 @entity0 received PC regimen and 33 received IEC regimen. @entity0 in both groups were well-matched with baseline disease characteristics(P > 0.05). RESULTS: In PC group, the response rate was 40.0% (14/35, 95% confidence interval [CI]: 23.8%-56.2%) (14 PR, 19 NC, 2 @entity7 ). Whereas in group IEC, the response rate was 21.2% (7/33, 95% CI: 7.3%-35.1%) (7 PR, 24 NC, 2 @entity7 ). The median survival and 1-year survival rate were 9.1 months (95% CI: 7.2-11.0 months) and 25.7% (95% CI: 11.2%-40.2%) for group PC versus 7.8 months (95% CI: 6.2-9.4 months) and 20.0% (95% CI: 6.0%-34.0%) for group IEC. The better response rate, 1-year survival rate, and the longer median survival seen in the group PC were not statistically significant (for response rate, P = 0.094, Chi-square test; for overall survival, P = 0.684, Log-rank test). The hematologic @entity2 , especially @entity6 (P < 0.0005, Wilcoxon rank sum test) and @entity3 (P = 0.006, Wilcoxon rank sum test) were less pronounced in group PC; @entity4 and fever were pronounced more in group IEC, whereas @entity1 was more in group PC, but there were no statistically significant differences between the two groups(P > 0.05, Wilcoxon rank sum test); Other @entity2 were similar. CONCLUSIONS: Compared with IEC regimen, PC regimen result in less hematologic @entity2 in the @entity0 with advanced NSCLC, Although whether its efficacy was better should be confirmed by well-controlled randomized clinical trials with more @entity0 .

title: [Comparison of paclitaxel and carboplatin versus ifosfamide, etoposide, and carboplatin regimen for treatment of XXXX with advanced @entity5 ].

answer: @entity0


abstract: UNASSIGNED: @entity4 ( @entity4 ) are rare, representing only 7-15% of @entity5 . The concentration of eloquent neurological structures and the high rate of @entity3 presentation of @entity4 in this location complicate the management of such lesions. New therapeutic options, especially in endovascular therapy, have fundamentally modified the treatment strategy and also the outcome of posterior fossa @entity4 . Between 1999 and 2013, baseline, clinical and angiographic data of @entity5 were prospectively collected. We analyzed data from @entity0 treated for a posterior fossa @entity4 , focusing on risk factors for @entity3 , and clinical and angiographic outcomes. Sixty-nine @entity0 (mean age 34years, male to female ratio 2:1) were consecutively treated for an infratentorial @entity4 . Fifty-seven presented with @entity3 , six with focal @entity1 , and the remaining six @entity0 were diagnosed incidentally. The Spetzler-Martin grade was <3 in 39 (56.5%) @entity0 . Associated @entity2 were noted in 43.5% of @entity0 . All @entity0 were treated using endovascular procedures, associated with microsurgical resection in nine @entity0 and with stereotactic radiosurgery in six. Mean follow-up was 28.5months, with angiographic exclusion of the @entity4 in 72.5% of @entity0 ; 21.7% of @entity0 presented a modified Rankin Score    3 at follow-up. Endovascular embolization seems to be a secure approach for posterior fossa @entity4 although a large number of sessions are necessary to achieve complete obliteration. Multi-disciplinary discussion and management is crucial to obtain the best cure rate without increasing procedural risks.

title: Endovascular treatment of posterior fossa XXXX .

answer: @entity4


abstract: BACKGROUND _ OBJECTIVES: The @entity0 with @entity1 usually have high telomerase activity, the pseudopositive result is happen frequently when the test is done with traditional method. Telomerase activity is more strongly correlated with @entity2 mRNA. This study was designed to detect the expression of telomerase @entity2 gene in broncho-alveolar lavage fluid of the @entity0 with @entity1 by relative quantitative RT-PCR method, to afford a useful tool for early and differentiate diagnosis of @entity1 . METHOD: The exfoliated cells in broncho-alveolar lavage fluid from 20 @entity0 @entity1 and 10 health @entity0 were analyzed for @entity2 expression by relative quantitative RT-PCR method, in the same time a part of exfoliated cells were detected with pathologic method. After operation, pathologic detection was performed for all samples. RESULTS: Of 20 @entity0 @entity1 and, 19 @entity0 were @entity1 , 1 @entity0 was @entity3 in pathological diagnosis after operation. The relative expression of telomerase @entity2 gene in 16 cases of 19 @entity0 with @entity1 were detected with the relative quantitative RT-PCR, the positive rate is 84.2% (16/19), the expressions of telomerase @entity2 gene were at various quantities, average levels is 0.42. The positive rate in exfoliated cells detected with pathologic method were 57.9% (11/19). There was a statistical difference between them(P < 0.01). Ten normal @entity0 were @entity2 gene expression negative. CONCLUSIONS: Relative quantitative RT-PCR were more sensitive than cell morphologic method in detecting telomerase @entity2 gene expression in broncho-alveolar lavage fluid of @entity0 with @entity1 . Detecting quantitatively the levels of telomerase @entity2 gene expression in broncho-alveolar lavage fluid will may be useful for early and differentiate @entity1 , especially for @entity1 .

title: [Detection of telomerase XXXX gene expression of exfoliated cell in broncho-alveolar lavage fluid].

answer: @entity2


abstract: BACKGROUND AND OBJECTIVE: The gap junction plays an important role in the exchange of nutrients, ions, and regulatory molecules between cells. It will result in an uncontrolled cell proliferation if it is abnormal. It was reported that some @entity1 tissues and @entity1 cells had abnormal gap junction and restoration of the gap junction function could revert the @entity1 cells to a normal phenotype. Therefore, to investigate the expression of connexin(cx) in @entity0 @entity2 , may provide a new way for clinical diagnosis and the pathogenesis of @entity2 . METHOD: The expressions of @entity3 and @entity6 in the biopsies of @entity2 ( @entity5 ) and chronic @entity4 tissues were determined by using the immunohistochemical staining. RESULTS: 1. @entity3 and @entity6 expressed differentially in @entity5 and chronic @entity4 tissues(P < 0.01). In @entity5 , expression of @entity3 and @entity6 were 44.8% and 46.6%, respectively, while in columnar cells of chronic @entity4 tissues, their expressions were 86.5% and 100% respectively, which were higher than those in @entity5 , 2. The percentage in squamous epithelial cells of chronic @entity4 tissues was 29.7%, which was lower than that in @entity5 , (56.9%). 3. The expressions of @entity3 and @entity6 in paracancer columnar epithelial cells were lower than that in paracancer squamous epithelial cells (P < 0.001), but higher than that in @entity5 cells (P < 0.01). CONCLUSIONS: The abnormal expression of @entity3 and @entity6 in nasopharynx tissues may be associated with cancerization and squamatization of @entity0 nasopharynx tissue.

title: [Expression of XXXX and @entity6 in @entity2 ].

answer: @entity3


abstract: BACKGROUND AND OBJECTIVE: The gap junction plays an important role in the exchange of nutrients, ions, and regulatory molecules between cells. It will result in an uncontrolled cell proliferation if it is abnormal. It was reported that some @entity1 tissues and @entity1 cells had abnormal gap junction and restoration of the gap junction function could revert the @entity1 cells to a normal phenotype. Therefore, to investigate the expression of connexin(cx) in @entity0 @entity2 , may provide a new way for clinical diagnosis and the pathogenesis of @entity2 . METHOD: The expressions of @entity3 and @entity6 in the biopsies of @entity2 ( @entity5 ) and chronic @entity4 tissues were determined by using the immunohistochemical staining. RESULTS: 1. @entity3 and @entity6 expressed differentially in @entity5 and chronic @entity4 tissues(P < 0.01). In @entity5 , expression of @entity3 and @entity6 were 44.8% and 46.6%, respectively, while in columnar cells of chronic @entity4 tissues, their expressions were 86.5% and 100% respectively, which were higher than those in @entity5 , 2. The percentage in squamous epithelial cells of chronic @entity4 tissues was 29.7%, which was lower than that in @entity5 , (56.9%). 3. The expressions of @entity3 and @entity6 in paracancer columnar epithelial cells were lower than that in paracancer squamous epithelial cells (P < 0.001), but higher than that in @entity5 cells (P < 0.01). CONCLUSIONS: The abnormal expression of @entity3 and @entity6 in nasopharynx tissues may be associated with cancerization and squamatization of @entity0 nasopharynx tissue.

title: [Expression of @entity3 and XXXX in @entity2 ].

answer: @entity6


abstract: BACKGROUND AND OBJECTIVE: The gap junction plays an important role in the exchange of nutrients, ions, and regulatory molecules between cells. It will result in an uncontrolled cell proliferation if it is abnormal. It was reported that some @entity1 tissues and @entity1 cells had abnormal gap junction and restoration of the gap junction function could revert the @entity1 cells to a normal phenotype. Therefore, to investigate the expression of connexin(cx) in @entity0 @entity2 , may provide a new way for clinical diagnosis and the pathogenesis of @entity2 . METHOD: The expressions of @entity3 and @entity6 in the biopsies of @entity2 ( @entity5 ) and chronic @entity4 tissues were determined by using the immunohistochemical staining. RESULTS: 1. @entity3 and @entity6 expressed differentially in @entity5 and chronic @entity4 tissues(P < 0.01). In @entity5 , expression of @entity3 and @entity6 were 44.8% and 46.6%, respectively, while in columnar cells of chronic @entity4 tissues, their expressions were 86.5% and 100% respectively, which were higher than those in @entity5 , 2. The percentage in squamous epithelial cells of chronic @entity4 tissues was 29.7%, which was lower than that in @entity5 , (56.9%). 3. The expressions of @entity3 and @entity6 in paracancer columnar epithelial cells were lower than that in paracancer squamous epithelial cells (P < 0.001), but higher than that in @entity5 cells (P < 0.01). CONCLUSIONS: The abnormal expression of @entity3 and @entity6 in nasopharynx tissues may be associated with cancerization and squamatization of @entity0 nasopharynx tissue.

title: [Expression of @entity3 and @entity6 in XXXX ].

answer: @entity2


abstract: BACKGROUND _ OBJECTIVE: Fragile @entity9 triad( @entity11 ), a @entity3 suppressor candidate gene, encompasses @entity11 , a common region with the highest fragility in the @entity1 genome, and is altered in a large number of @entity1 @entity3 , particularly those of epithelial cell origin and associated with known carcinogenic agents. The aim of this study was to investigate the expression of @entity11 protein, @entity11 and the possible relationship between @entity11 expression and clinicopathological indices in @entity0 . METHODS: @entity11 protein expression in 66 cases of @entity5 -fixed, @entity7 -embedded @entity0 composed of 6 in situ and 60 @entity6 were detected with @entity8 -microwave-Streptavidin-HRP(SP) immunohistochemical method, using rabbit antibody to @entity1 @entity11 gene protein and relationships to invasion and lymphatic @entity2 were analyzed. RESULTS: Thirty-eight (57.6%) cases of @entity4 showed a marked loss or absence of @entity11 expression compared with the adjacent non-cancerous breast tissues, in which 22 cases were negative. The remain 18 (27.3%) showed stronger than, and 10 (15.2%) equal to the @entity11 expression of the adjacent non-cancerous tissue. The lower expression of @entity11 was found in 20/24(83.3%) cases with local or axillary lymphatic @entity2 , and in 18/36 (50%) cases without @entity2 in the @entity6 . @entity11 expression was determined in all 6 cases of @entity10 did not show lower than non-cancerous tissue. There was a significant difference in the expression of @entity11 between the @entity0 with and without lymphatic @entity2 , both in @entity6 (P < 0.01) and in @entity6 (P < 0.01). CONCLUSIONS: The expression of @entity11 is associated with invasion and @entity2 of @entity3 in @entity0 . It is suggested that decreased @entity11 expression may play an important role in the development and progression of the @entity3 , and thus may become a new prognostic marker for @entity0 .

title: [Loss of fragile XXXX triad expression and @entity2 in @entity0 ].

answer: @entity9


abstract: BACKGROUND _ OBJECTIVE: Fragile @entity9 triad( @entity11 ), a @entity3 suppressor candidate gene, encompasses @entity11 , a common region with the highest fragility in the @entity1 genome, and is altered in a large number of @entity1 @entity3 , particularly those of epithelial cell origin and associated with known carcinogenic agents. The aim of this study was to investigate the expression of @entity11 protein, @entity11 and the possible relationship between @entity11 expression and clinicopathological indices in @entity0 . METHODS: @entity11 protein expression in 66 cases of @entity5 -fixed, @entity7 -embedded @entity0 composed of 6 in situ and 60 @entity6 were detected with @entity8 -microwave-Streptavidin-HRP(SP) immunohistochemical method, using rabbit antibody to @entity1 @entity11 gene protein and relationships to invasion and lymphatic @entity2 were analyzed. RESULTS: Thirty-eight (57.6%) cases of @entity4 showed a marked loss or absence of @entity11 expression compared with the adjacent non-cancerous breast tissues, in which 22 cases were negative. The remain 18 (27.3%) showed stronger than, and 10 (15.2%) equal to the @entity11 expression of the adjacent non-cancerous tissue. The lower expression of @entity11 was found in 20/24(83.3%) cases with local or axillary lymphatic @entity2 , and in 18/36 (50%) cases without @entity2 in the @entity6 . @entity11 expression was determined in all 6 cases of @entity10 did not show lower than non-cancerous tissue. There was a significant difference in the expression of @entity11 between the @entity0 with and without lymphatic @entity2 , both in @entity6 (P < 0.01) and in @entity6 (P < 0.01). CONCLUSIONS: The expression of @entity11 is associated with invasion and @entity2 of @entity3 in @entity0 . It is suggested that decreased @entity11 expression may play an important role in the development and progression of the @entity3 , and thus may become a new prognostic marker for @entity0 .

title: [Loss of fragile @entity9 triad expression and XXXX in @entity0 ].

answer: @entity2


abstract: BACKGROUND _ OBJECTIVE: Fragile @entity9 triad( @entity11 ), a @entity3 suppressor candidate gene, encompasses @entity11 , a common region with the highest fragility in the @entity1 genome, and is altered in a large number of @entity1 @entity3 , particularly those of epithelial cell origin and associated with known carcinogenic agents. The aim of this study was to investigate the expression of @entity11 protein, @entity11 and the possible relationship between @entity11 expression and clinicopathological indices in @entity0 . METHODS: @entity11 protein expression in 66 cases of @entity5 -fixed, @entity7 -embedded @entity0 composed of 6 in situ and 60 @entity6 were detected with @entity8 -microwave-Streptavidin-HRP(SP) immunohistochemical method, using rabbit antibody to @entity1 @entity11 gene protein and relationships to invasion and lymphatic @entity2 were analyzed. RESULTS: Thirty-eight (57.6%) cases of @entity4 showed a marked loss or absence of @entity11 expression compared with the adjacent non-cancerous breast tissues, in which 22 cases were negative. The remain 18 (27.3%) showed stronger than, and 10 (15.2%) equal to the @entity11 expression of the adjacent non-cancerous tissue. The lower expression of @entity11 was found in 20/24(83.3%) cases with local or axillary lymphatic @entity2 , and in 18/36 (50%) cases without @entity2 in the @entity6 . @entity11 expression was determined in all 6 cases of @entity10 did not show lower than non-cancerous tissue. There was a significant difference in the expression of @entity11 between the @entity0 with and without lymphatic @entity2 , both in @entity6 (P < 0.01) and in @entity6 (P < 0.01). CONCLUSIONS: The expression of @entity11 is associated with invasion and @entity2 of @entity3 in @entity0 . It is suggested that decreased @entity11 expression may play an important role in the development and progression of the @entity3 , and thus may become a new prognostic marker for @entity0 .

title: [Loss of fragile @entity9 triad expression and @entity2 in XXXX ].

answer: @entity0


abstract: @entity2 are one of the most commonly occurring @entity1 in the age groups heavily represented in the U.S. Navy. The Navy has a wide range of potential occupational exposures. This study was initiated to identify any occupational associations of @entity2 that may adversely affect naval readiness. The objective of this study was to compare the incidence of @entity2 in U.S. Navy active duty enlisted personnel during the period 1974-1983 with the general U.S. population, and to assess if risk varied by naval occupation or length of service. The Naval Health Research Center's computer-based disease registry was used to conduct a prospective study of all white U.S. Navy enlisted @entity0 during 1974-1983 to test for the existence of any short-term risk possibly due to occupation. @entity0 in 80 occupations, ranging from clerk to journalist to machinist and boiler operator were observed for 3,704,864 @entity0 -years; mean length of service was 5.1 yr, but 19% of @entity0 -years were contributed by @entity0 who had served at least 11 yr. Incident cases of @entity2 were identified and verified using Medical Board findings or review of original medical records. Average annual age-specific and age-adjusted incidence rates were calculated. Examination of pathology records and medical review boards confirmed 68 cases of @entity2 . The annual age-adjusted incidence rate per 100,000 @entity0 -years in Navy @entity0 was significantly lower than in the U.S. Surveillance, Epidemiology, and End Results (SEER) population, probably due to screening and other selection factors associated with Navy service that result in a healthy worker effect.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX in U.S. Navy personnel.

answer: @entity2


abstract: AIM: The aim of the present study was to estimate the clinical effectiveness of @entity3 -PET/CT in the detection of the @entity2 in @entity0 with histologically proven @entity5 cervical lymph nodes @entity1 from an unknown primary. BACKGROUND: @entity3 positron emission tomography combined with CT ( @entity3 -PET/CT) is believed to be very helpful in localization of @entity2 in @entity4 @entity0 . MATERIAL AND METHOD: 41 @entity0 referred to Poznan Medical University Department of Head and Neck Surgery from January 2010 to December 2013 with @entity4 were included in the study. All @entity0 presented fine-needle biopsy proven @entity5 @entity1 of the upper-, or mid neck lymph nodes. The final results were obtained from the histopathologic reports of tissue samples from anatomical regions suspected for @entity2 , additional imaging exams as well as clinical follow-up data. RESULTS: The @entity3 -PET/CT successfully detected @entity2 in 7 out of 41 @entity0 (17%). In two more cases the @entity2 was indicated in the lung. 24 of 41 @entity0 (58.5%) analyzed in our study remained without evidence of a @entity2 . In 4 cases (9.75%) we did not reveal any pathology within the localizations indicated by PET/CT on panendoscopy. In 4 cases we obtained histological confirmation of @entity2 on panendoscopy despite the negative results of PET/CT examinations. CONCLUSION: We may suppose a relatively high usefulness of @entity3 -PET/CT in the diagnosis process of @entity4 @entity0 . High NPV may indicate @entity0 with no symptoms of @entity2 , which allows to avoid extensive resection or extra imaging.

title: Carcinoma of unknown primary in the head and neck: The evaluation of the effectiveness of XXXX -PET/CT, own experience.

answer: @entity3


abstract: The protective effect of severe @entity3 ( @entity3 ) against left @entity6 formation has been well documented. It was also proposed that severe @entity3 may prevent @entity6 formation within the left ventricle (LV) with @entity2 . Therefore, we investigated whether ischemic @entity3 prevents @entity6 formation within the LV in @entity0 with @entity2 . The study population was comprised of 1313 @entity0 (1133 males, 180 females, age 56+/-18) with @entity8 documented by coronary angiography and left ventriculography. None of the @entity0 had a history of chronic anticoagulation. Epicardial coronary arteries were normal in 91 @entity0 , and single-vessel, two-vessel, and @entity1 were detected in 328, 330, and 564 @entity0 , respectively. @entity8 and severe @entity3 were detected in 191 (14.5%) and 125 (9.5%) @entity0 , respectively. Overall incidence of @entity9 was lower in @entity0 with severe @entity3 than in @entity0 without severe @entity3 (4% vs 15.6%, OR: 0.2, P<0.001). Severe @entity3 compared with absence of severe @entity3 was associated with a lower incidence of @entity9 both in @entity0 with @entity4 (6.8% vs 34.2%, OR: 0.19, P<0.001), and in @entity0 with @entity5 (3% vs 18%, OR: 0.14, P<0.0001) involving anterolateral, septal and/or apical LV segments. A similar trend without statistical significance was also observed in @entity0 with @entity7 (4.7% vs 16%, OR: 0.26, P=0.1) related to anterolateral, septal and/or apical LV segments. However, @entity3 had no impact on the incidence of @entity9 in @entity0 with @entity5 or @entity7 related to posterior and/or inferior segments (3.7% vs 3%, OR: 1.2, P>0.05). In conclusion, severe @entity3 seems to prevent LV mural @entity6 formation in @entity0 with @entity4 , and in @entity0 with @entity5 related to anterolateral, septal, and/or apical LV segments. This relative risk reduction may be associated with diastolic volume overloading due to severe @entity3 which may overcome stagnation and a procoagulant state within the LV with severe @entity2 .

title: Severe XXXX may prevent mural @entity6 formation within the left ventricle with @entity2 .

answer: @entity3


abstract: The protective effect of severe @entity3 ( @entity3 ) against left @entity6 formation has been well documented. It was also proposed that severe @entity3 may prevent @entity6 formation within the left ventricle (LV) with @entity2 . Therefore, we investigated whether ischemic @entity3 prevents @entity6 formation within the LV in @entity0 with @entity2 . The study population was comprised of 1313 @entity0 (1133 males, 180 females, age 56+/-18) with @entity8 documented by coronary angiography and left ventriculography. None of the @entity0 had a history of chronic anticoagulation. Epicardial coronary arteries were normal in 91 @entity0 , and single-vessel, two-vessel, and @entity1 were detected in 328, 330, and 564 @entity0 , respectively. @entity8 and severe @entity3 were detected in 191 (14.5%) and 125 (9.5%) @entity0 , respectively. Overall incidence of @entity9 was lower in @entity0 with severe @entity3 than in @entity0 without severe @entity3 (4% vs 15.6%, OR: 0.2, P<0.001). Severe @entity3 compared with absence of severe @entity3 was associated with a lower incidence of @entity9 both in @entity0 with @entity4 (6.8% vs 34.2%, OR: 0.19, P<0.001), and in @entity0 with @entity5 (3% vs 18%, OR: 0.14, P<0.0001) involving anterolateral, septal and/or apical LV segments. A similar trend without statistical significance was also observed in @entity0 with @entity7 (4.7% vs 16%, OR: 0.26, P=0.1) related to anterolateral, septal and/or apical LV segments. However, @entity3 had no impact on the incidence of @entity9 in @entity0 with @entity5 or @entity7 related to posterior and/or inferior segments (3.7% vs 3%, OR: 1.2, P>0.05). In conclusion, severe @entity3 seems to prevent LV mural @entity6 formation in @entity0 with @entity4 , and in @entity0 with @entity5 related to anterolateral, septal, and/or apical LV segments. This relative risk reduction may be associated with diastolic volume overloading due to severe @entity3 which may overcome stagnation and a procoagulant state within the LV with severe @entity2 .

title: Severe @entity3 may prevent mural @entity6 formation within the left ventricle with XXXX .

answer: @entity2


abstract: The protective effect of severe @entity3 ( @entity3 ) against left @entity6 formation has been well documented. It was also proposed that severe @entity3 may prevent @entity6 formation within the left ventricle (LV) with @entity2 . Therefore, we investigated whether ischemic @entity3 prevents @entity6 formation within the LV in @entity0 with @entity2 . The study population was comprised of 1313 @entity0 (1133 males, 180 females, age 56+/-18) with @entity8 documented by coronary angiography and left ventriculography. None of the @entity0 had a history of chronic anticoagulation. Epicardial coronary arteries were normal in 91 @entity0 , and single-vessel, two-vessel, and @entity1 were detected in 328, 330, and 564 @entity0 , respectively. @entity8 and severe @entity3 were detected in 191 (14.5%) and 125 (9.5%) @entity0 , respectively. Overall incidence of @entity9 was lower in @entity0 with severe @entity3 than in @entity0 without severe @entity3 (4% vs 15.6%, OR: 0.2, P<0.001). Severe @entity3 compared with absence of severe @entity3 was associated with a lower incidence of @entity9 both in @entity0 with @entity4 (6.8% vs 34.2%, OR: 0.19, P<0.001), and in @entity0 with @entity5 (3% vs 18%, OR: 0.14, P<0.0001) involving anterolateral, septal and/or apical LV segments. A similar trend without statistical significance was also observed in @entity0 with @entity7 (4.7% vs 16%, OR: 0.26, P=0.1) related to anterolateral, septal and/or apical LV segments. However, @entity3 had no impact on the incidence of @entity9 in @entity0 with @entity5 or @entity7 related to posterior and/or inferior segments (3.7% vs 3%, OR: 1.2, P>0.05). In conclusion, severe @entity3 seems to prevent LV mural @entity6 formation in @entity0 with @entity4 , and in @entity0 with @entity5 related to anterolateral, septal, and/or apical LV segments. This relative risk reduction may be associated with diastolic volume overloading due to severe @entity3 which may overcome stagnation and a procoagulant state within the LV with severe @entity2 .

title: Severe @entity3 may prevent mural XXXX formation within the left ventricle with @entity2 .

answer: @entity6


abstract: @entity6 remains comparatively rare, and is a non-hereditary cartilage @entity5 of bone. It is usually associated with problems such as @entity4 . Three different methods were used in a one-hand of 15-year-old @entity0 reporting his @entity3 in the left hand and swellings. After the curettage of @entity1 , regarding as the differences of all parts of the bone structure reconstruction in the @entity0 's hand, we chose three following methods for this @entity0 , i.e. fixed by the locking plate with @entity2 cement, filled with allograft bone, curetted the @entity1 without any bone graft. After the surgery, the @entity0 was able to perform full motion of the operated hand. No evidence of recurrence was noted four years after surgery. To choose the different ways with bone grafts or not that relies on the @entity0 ' conditions for bone structure reconstruction. However, @entity0 with large osseous defects or pathological @entity4 , we demand full bone graft and reliable internal fixation. After surgery, early exercises can reach a desirable result and functional recovery.

title: Three different methods for treating XXXX in one hand.

answer: @entity6


abstract: The flexible laryngeal mask airway (FLMA) is becoming more and more popular in general anesthesia during surgery of head, neck and upper chest. But very limited information has been published about whether muscle relaxant was necessary or not for anesthesia with FLMA. To investigate whether low-dose muscle relaxant is necessary in preventing ventilation leak of FLMA in radical mastectomy, forty-eight female @entity0 undergoing radical mastectomy were enrolled in the study. They were randomly divided into low-dose muscle relaxant (LD-MR) group and non-muscle relaxant (non-MR) group. All the included @entity0 received total intravenous anesthesia (with @entity1 , @entity4 and @entity2 ) and controlled mechanical ventilation with FLMA during the surgery. @entity0 in LD-MR group received 0.4 mg/kg @entity3 during anesthesia induction, while @entity0 in non-MR group received equivalent volumes of physiological saline. Insertion time was shorter in LD-MR group than that in non-MR group (P < 0.05). Peak airway pressures and ventilation leak volumes at 10, 20 and 30 minutes were lower in LD-MR group than those in non-MR group (P < 0.05). No difference was found between LD-MR and non-MR group in terms of emergence time, FLMA extraction time, and maximum tidal volumes before FLMA extraction. The results show that low-dose @entity3 could reduce the ventilation leak for mechanical ventilation with FLMA during radical mastectomy without prolonging the emergence time.

title: Effect of low dose XXXX in preventing ventilation leak for flexible laryngeal mask airway during radical mastectomy.

answer: @entity3