abstract: OBJECTIVE: Following @entity3 , both @entity1 and @entity2 are common. Unfortunately, little is known regarding the potential associations between these 2 symptoms during acute recovery. This study sought to prospectively examine the relationship between ratings of @entity1 and serial cognitive assessments among @entity3 acute neurorehabilitation admissions. METHODS: @entity0 were consecutive admissions to a free-standing rehabilitation hospital following moderate to severe @entity3 (Median Emergency Department Glasgow @entity4 Scale = 7). @entity0 were assessed for sleep-wake cycle disturbance (SWCD) and cognitive functioning at admission and with subsequent weekly examinations. @entity0 were grouped on the basis of presence (SWCD+) or absence (SWCD-) of @entity1 for each examination; groups were equivalent on demographic and injury variables. Individual Growth Curve modeling was used to examine course of Cognitive Test for @entity5 performance across examinations. RESULTS: Individual Growth Curve modeling revealed a significant interaction between examination number (ie, time) and SWCD group (b = -4.03, P < .001) on total Cognitive Test for @entity5 score. The SWCD+ ratings on later examinations were predicted to result in lower Cognitive Test for @entity5 scores and greater @entity2 over time. CONCLUSIONS: This study has implications for improving neurorehabilitation treatment, as targeting @entity1 for early intervention may facilitate cognitive recovery.

title: The Relationship Between Sleep-Wake Cycle Disturbance and Trajectory of Cognitive Recovery During Acute XXXX .

answer: @entity3


abstract: @entity6 has reached epidemic proportions in industrialized nations. New therapies are urgently sought. Using a combination of animal models of @entity1 and @entity0 biopsy samples, a pattern of dysregulated microRNA expression has emerged which is common to @entity5 . A number of these dysregulated microRNA have recently been shown to have functional consequences for the disease process and therefore may be potential therapeutic targets. We highlight @entity7 , the most comprehensively studied microRNA in the kidney so far. @entity7 is expressed widely in healthy kidney but studies from knockout @entity2 indicate it is largely inert. Although @entity7 is upregulated in many cell compartments including leukocytes, epithelial cells and myofibroblasts, the inert @entity7 also appears to become activated, by unclear mechanisms. @entity2 lacking @entity7 are protected from @entity1 and @entity4 in several distinct models of @entity1 , and systemically administered oligonucleotides that specifically bind to the active site in @entity7 , inhibiting its function, recapitulate the genetic deletion of @entity7 , suggesting inhibitory oligonucleotides may have therapeutic potential. Recent studies of @entity7 targets in kidney indicate that it normally functions to silence metabolic pathways including @entity8 metabolism and pathways that prevent Reactive @entity3 Species generation in peroxisomes and mitochondria in epithelial cells and myofibroblasts. Targeting specific pathogenic microRNAs in a specific manner is feasible in vivo and may be a new therapeutic target in disease of the kidney.

title: MicroRNAs are potential therapeutic targets in fibrosing XXXX : lessons from animal models.

answer: @entity1


abstract: Malignant Infantile @entity7 (MIOP) is a rare @entity1 due to osteoclast abnormal activity. We report a thirteen month-old male @entity0 , diagnosed as MIOP while investigating the cause of @entity3 associated with @entity5 . His medical history revealed non consanguineous parents and one brother's death at the same age of unknown etiology (similar symptoms). Systemic examination showed @entity3 , @entity4 , developmental milestones delay, and rickets features. Ophthalmic exam yielded bilateral @entity6 . Skeleton radiographs detected generalized dense bone and rickets. Cerebral CT scan revealed @entity5 . Histological examination showed hypoplastic bone marrow and extra-medullary hematopoeisis. Diagnosis was confirmed by genetic testing that showed two heterozygote mutations within the @entity8 gene. The @entity0 received supportive treatment. He died from an acute @entity2 . MIOP should be kept in mind as a rare cause of @entity3 . Early diagnosis and timely Hematopoietic stem cell transplantation are the only curative approach for an otherwise fatal disease.

title: Malignant infantile XXXX : case report with review of literature.

answer: @entity7


abstract: PURPOSE: The aim of this analysis was to implement a claims-based algorithm to estimate biologic cost per effectively treated @entity0 for biologics approved for moderate to severe @entity1 ( @entity1 ). METHODS: This retrospective analysis included commercially insured adults (aged 18-63 years) with @entity1 in a commercial database, who initiated biologic treatment with abatacept, adalimumab, etanercept, golimumab, or infliximab between 2007 and 2010. The algorithm defined effectiveness as having all of the following: high adherence, no biologic dose increase, no biologic switching, no new nonbiologic disease-modifying antirheumatic drug, no increased or new oral glucocorticoid use, and no more than 1 glucocorticoid injection. For each biologic, cost per effectively treated @entity0 was defined as total drug and administration costs (from allowed amounts on claims), divided by the number of @entity0 categorized as effectively treated. FINDINGS: Of 15,351 @entity0 , 12,018 (78.3%) were @entity0 , and the mean (SD) age was 49.7 (9.6) years. The algorithm categorized treatment as effective in the first year for 30% (1899/6374) of etanercept, 30% (1396/4661) of adalimumab, 20% (560/2765) of infliximab, 27% (361/1338) of abatacept, and 29% (62/213) of golimumab treated @entity0 . The 1-year biologic cost per effectively treated @entity0 , as defined by the algorithm, was nominally lower for subcutaneously injected biologics than for infused biologics. The 1-year biologic cost per effectively treated @entity0 , as defined by the algorithm, was lowest for etanercept ( 49,952), followed by golimumab ( 50,189), adalimumab ( 52,858), abatacept ( 71,866), and infliximab ( 104,333). IMPLICATIONS: Algorithm-defined effectiveness was similar for biologics other than infliximab. The 1-year biologic cost per effectively treated @entity0 , as defined by the algorithm, was nominally lower for subcutaneously injected biologics than for infused biologics.

title: Estimating effectiveness and cost of biologics for XXXX : application of a validated algorithm to commercial insurance claims.

answer: @entity1


abstract: Purpose: In the last decades, new evidences supported the relationship polymorphisms and the susceptibility to develop ligament and @entity3 . We performed a review of the genetic factors involved in tendon and @entity2 . Methods: We performed a systematic review of the literature using the terms "sports", "ligaments", "injuries", "tendon" and "genetics". A comprehensive search of PubMed, Medline, CINAHL, Cochrane, Embase and Google Scholar databases was performed over the years 1984-2014. Results: The genes currently associated with tendon and @entity2 include gene encoding for collagen, tenascin, matrix metallopeptidase, and growth factors. Conclusions: Tendon and @entity2 do not have a single genetic cause. They are associated with the effects of multiple genes in combination with lifestyle and environmental factors. Although @entity1 often cluster in families, they do not have a clear-cut pattern of inheritance. This makes it difficult to determine a @entity0 's risk of inheriting or passing on these disorders. @entity1 are also difficult to study and treat because the specific factors that cause most of these disorders have not yet been identified. Researchers continue to look for major contributing genes for @entity1 .

title: Unravelling the Genetic Susceptibility to Develop Ligament and XXXX .

answer: @entity3


abstract: BACKGROUND/AIMS: @entity5 ( @entity5 ) and @entity6 ( @entity6 ) are common diseases with a vast number of acquired and congenital risk factors. @entity9 are not established risk factors for @entity7 ( @entity7 ) so far. However, in recent literature, associations between @entity7 and the @entity3 , especially with elevated lipid parameters, have been described. The aim of our study was to investigate the association between the extension of @entity7 and changes in the lipid profile. METHODS: We included 178 @entity7 @entity0 in our study; 59 @entity0 had isolated @entity6 , 39 @entity0 had isolated @entity5 of the leg and 80 @entity0 had both ( @entity5 and @entity6 ). Concerning @entity6 , we distinguished between massive and submassive @entity6 . We evaluated plasma lipids and lipoproteins in @entity6 and @entity5 @entity0 as well as in massive and submassive @entity6 @entity0 . RESULTS: @entity6 @entity0 had higher levels of plasma @entity8 [median (interquartile range): 162 (109-254) vs. 136.5 (96.5-162) mg/dl, p = 0.047] and lower levels of high-density lipoprotein @entity2 (HDL-C; 52.1    17.2 vs. 63.9    22.7 mg/dl, p = 0.004) than @entity5 @entity0 . Furthermore, @entity6 @entity0 were significantly older than @entity5 @entity0 (59.6    16.9 vs. 52.2    15.5 years, p = 0.02). We were not able to find differences in lipid parameters in @entity0 with massive @entity6 compared to those with submassive @entity6 . However, @entity0 with massive @entity6 were more @entity1 than @entity0 with submassive @entity6 (body mass index 29.1    4.6 vs. 26.9    4.9, p = 0.012). CONCLUSIONS: Lipid parameters and lipoproteins differ between @entity5 and @entity6 @entity0 . @entity6 @entity0 had higher @entity4 and lower HDL-C levels compared with @entity5 @entity0 .

title: Changes in lipid metabolism and extension of XXXX .

answer: @entity7


abstract: OBJECTIVE: Sleep disturbances, such as @entity8 ( @entity8 ) and excessive @entity1 , are more common in @entity0 with @entity4 ( @entity4 ) than in the general population. Apart from that, their relation to @entity4 seems to diverge considerably. Our aim was to explore the frequency and associated motor- and non-motor features of @entity1 in @entity4 . METHODS: One hundred and seven @entity0 with @entity4 , 65 @entity0 and 42 @entity0 , were included in a cross-sectional study. Excessive @entity1 was examined by the @entity1 scale. Probable @entity8 (pRBD) was diagnosed by the validated @entity8 screening questionnaire. Further sleep symptoms were explored by the @entity4 sleep scale. Motor- and non-motor symptoms were assessed and compared in @entity0 with and without pRBD and excessive @entity1 , respectively. RESULTS: pRBD was present in 38% and excessive @entity1 was present in 29% of the @entity0 . As opposed to excessive @entity1 , pRBD showed no association to disease duration or severity. @entity4 @entity0 with pRBD reported more @entity2 . There was a trend towards more @entity7 in @entity0 with pRBD. @entity6 and @entity5 were the most frequent general @entity1 reported by the @entity0 . CONCLUSIONS: Our results suggest that excessive @entity1 is related to disease duration, and possibly caused by progressive @entity3 . pRBD seems to be a distinct feature present in only a proportion of @entity4 @entity0 .

title: Clinical features associated with XXXX in @entity4 .

answer: @entity1


abstract: OBJECTIVE: Sleep disturbances, such as @entity8 ( @entity8 ) and excessive @entity1 , are more common in @entity0 with @entity4 ( @entity4 ) than in the general population. Apart from that, their relation to @entity4 seems to diverge considerably. Our aim was to explore the frequency and associated motor- and non-motor features of @entity1 in @entity4 . METHODS: One hundred and seven @entity0 with @entity4 , 65 @entity0 and 42 @entity0 , were included in a cross-sectional study. Excessive @entity1 was examined by the @entity1 scale. Probable @entity8 (pRBD) was diagnosed by the validated @entity8 screening questionnaire. Further sleep symptoms were explored by the @entity4 sleep scale. Motor- and non-motor symptoms were assessed and compared in @entity0 with and without pRBD and excessive @entity1 , respectively. RESULTS: pRBD was present in 38% and excessive @entity1 was present in 29% of the @entity0 . As opposed to excessive @entity1 , pRBD showed no association to disease duration or severity. @entity4 @entity0 with pRBD reported more @entity2 . There was a trend towards more @entity7 in @entity0 with pRBD. @entity6 and @entity5 were the most frequent general @entity1 reported by the @entity0 . CONCLUSIONS: Our results suggest that excessive @entity1 is related to disease duration, and possibly caused by progressive @entity3 . pRBD seems to be a distinct feature present in only a proportion of @entity4 @entity0 .

title: Clinical features associated with @entity1 in XXXX .

answer: @entity4


abstract: Broad @entity0 have been consistently demonstrated in well-established @entity2 . The aim of the current study was to systematically review neuropsychological studies in first-episode @entity2 to determine the breadth, extent and predictors of @entity1 at this early stage of illness through meta-analytic procedures. Electronic databases were searched for studies published between January 1980 and December 2013. Twelve studies met eligibility criteria (N  =  341, mean age  =  28.2 years), and pooled effect sizes (ES) were calculated across eight cognitive domains. Moderator analyses were conducted to identify predictors of between-study heterogeneity. Controlling for known confounds, medium to large deficits (ES  >=   0.5) in psychomotor speed, @entity5 , and @entity1 were identified, whereas @entity0 (ES 0.20-0.49) were found in the domains of verbal learning and memory, attentional switching, and verbal fluency. A medium to large deficit in response inhibition was only detected in non-euthymic cases. Visual learning and memory functioning was not significantly worse in cases compared with controls. Overall, first-episode @entity2 are associated with widespread @entity1 . Since euthymia was not associated with superior cognitive performance in most domains, these results indicate that even in the earliest stages of disease, @entity1 are not mood-state dependent. The current findings have important implications for whether @entity1 represent @entity3 . Future studies need to more clearly characterise the presence of @entity4 features, and the nature and number of previous mood episodes.

title: A meta-analysis of neuropsychological functioning in first-episode XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity2 + T cell exhaustion commonly occurs in @entity0 . During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deletion of antigen specific cells by apoptosis. A key factor that regulates T cell exhaustion is persistent TCR stimulation. Loss of this interaction results in restoration of @entity2 + T cell effector functions in previously exhausted @entity2 + T cells. TCR stimulation is also important for the differentiation of Eomeshi anti-viral @entity2 + effector T cells from T-bethi precursors, both of which are required for optimal viral control. However, the molecular mechanisms regulating the differentiation of these two cell subsets and the relative ratios required for viral clearance have not been described. We show that TCR signal strength regulates the relative expression of @entity4 and @entity5 in antigen-specific @entity2 + T cells by modulating levels of @entity6 . Reduced @entity6 expression results in skewing of this ratio in the favor of @entity5 , leading to lower proportions and numbers of @entity4 + @entity5 - precursors and poor control of @entity7 -clone 13 @entity1 . Manipulation of this ratio in the favor of @entity4 restores the differentiation of @entity4 + @entity5 - precursors and the protective balance of @entity4 to @entity5 required for efficient viral control. These data highlight a critical role for @entity6 in regulating protective anti-viral @entity2 + T cell responses by ensuring a balanced ratio of @entity4 to @entity5 , leading to the ultimate control of this chronic @entity3 .

title: XXXX Regulates the Ratio of @entity4 to Eomesodermin in @entity2 + T Cells Responding to Persistent @entity7 Infection.

answer: @entity6


abstract: UNASSIGNED: @entity2 + T cell exhaustion commonly occurs in @entity0 . During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deletion of antigen specific cells by apoptosis. A key factor that regulates T cell exhaustion is persistent TCR stimulation. Loss of this interaction results in restoration of @entity2 + T cell effector functions in previously exhausted @entity2 + T cells. TCR stimulation is also important for the differentiation of Eomeshi anti-viral @entity2 + effector T cells from T-bethi precursors, both of which are required for optimal viral control. However, the molecular mechanisms regulating the differentiation of these two cell subsets and the relative ratios required for viral clearance have not been described. We show that TCR signal strength regulates the relative expression of @entity4 and @entity5 in antigen-specific @entity2 + T cells by modulating levels of @entity6 . Reduced @entity6 expression results in skewing of this ratio in the favor of @entity5 , leading to lower proportions and numbers of @entity4 + @entity5 - precursors and poor control of @entity7 -clone 13 @entity1 . Manipulation of this ratio in the favor of @entity4 restores the differentiation of @entity4 + @entity5 - precursors and the protective balance of @entity4 to @entity5 required for efficient viral control. These data highlight a critical role for @entity6 in regulating protective anti-viral @entity2 + T cell responses by ensuring a balanced ratio of @entity4 to @entity5 , leading to the ultimate control of this chronic @entity3 .

title: @entity6 Regulates the Ratio of @entity4 to Eomesodermin in @entity2 + T Cells Responding to Persistent XXXX Infection.

answer: @entity7


abstract: UNASSIGNED: @entity2 + T cell exhaustion commonly occurs in @entity0 . During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deletion of antigen specific cells by apoptosis. A key factor that regulates T cell exhaustion is persistent TCR stimulation. Loss of this interaction results in restoration of @entity2 + T cell effector functions in previously exhausted @entity2 + T cells. TCR stimulation is also important for the differentiation of Eomeshi anti-viral @entity2 + effector T cells from T-bethi precursors, both of which are required for optimal viral control. However, the molecular mechanisms regulating the differentiation of these two cell subsets and the relative ratios required for viral clearance have not been described. We show that TCR signal strength regulates the relative expression of @entity4 and @entity5 in antigen-specific @entity2 + T cells by modulating levels of @entity6 . Reduced @entity6 expression results in skewing of this ratio in the favor of @entity5 , leading to lower proportions and numbers of @entity4 + @entity5 - precursors and poor control of @entity7 -clone 13 @entity1 . Manipulation of this ratio in the favor of @entity4 restores the differentiation of @entity4 + @entity5 - precursors and the protective balance of @entity4 to @entity5 required for efficient viral control. These data highlight a critical role for @entity6 in regulating protective anti-viral @entity2 + T cell responses by ensuring a balanced ratio of @entity4 to @entity5 , leading to the ultimate control of this chronic @entity3 .

title: @entity6 Regulates the Ratio of XXXX to Eomesodermin in @entity2 + T Cells Responding to Persistent @entity7 Infection.

answer: @entity4


abstract: UNASSIGNED: @entity2 + T cell exhaustion commonly occurs in @entity0 . During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deletion of antigen specific cells by apoptosis. A key factor that regulates T cell exhaustion is persistent TCR stimulation. Loss of this interaction results in restoration of @entity2 + T cell effector functions in previously exhausted @entity2 + T cells. TCR stimulation is also important for the differentiation of Eomeshi anti-viral @entity2 + effector T cells from T-bethi precursors, both of which are required for optimal viral control. However, the molecular mechanisms regulating the differentiation of these two cell subsets and the relative ratios required for viral clearance have not been described. We show that TCR signal strength regulates the relative expression of @entity4 and @entity5 in antigen-specific @entity2 + T cells by modulating levels of @entity6 . Reduced @entity6 expression results in skewing of this ratio in the favor of @entity5 , leading to lower proportions and numbers of @entity4 + @entity5 - precursors and poor control of @entity7 -clone 13 @entity1 . Manipulation of this ratio in the favor of @entity4 restores the differentiation of @entity4 + @entity5 - precursors and the protective balance of @entity4 to @entity5 required for efficient viral control. These data highlight a critical role for @entity6 in regulating protective anti-viral @entity2 + T cell responses by ensuring a balanced ratio of @entity4 to @entity5 , leading to the ultimate control of this chronic @entity3 .

title: @entity6 Regulates the Ratio of @entity4 to Eomesodermin in XXXX + T Cells Responding to Persistent @entity7 Infection.

answer: @entity2


abstract: OBJECTIVE: Elderly @entity2 @entity0 are characterized by blood pressure (BP) variability, impaired autonomic function, and vascular @entity3 and stiffness. However, the mechanisms causing these conditions are unclear. The present study examined the effect of angiotensin receptor blockers (ARBs) on aged spontaneously @entity2 @entity1 (SHR). METHODS: We surgically implanted telemetry devices in SHR and WKY at the age of 15 weeks (Young) and 80 weeks (Aged). Aged SHR were orally administered either @entity7 or @entity4 once daily at 19:00  h (at the beginning of the dark period (active phase)) for 4 weeks to examine the effects on BP variability, impaired autonomic function, and vascular senescence. RESULTS: Aging and @entity2 in SHR additively caused the following: increased low frequency (LF) power of systolic BP, a decreased spontaneous baroreceptor reflex gain (sBRG), increased BP variability, increased urinary @entity5 excretion, increased vascular senescence-related beta-galactosidase positive cells and oxidative stress. Treatment with @entity7 or @entity4 significantly ameliorated these changes in aged SHR. However, @entity7 ameliorated these changes in aged SHR better than @entity4 . The reductions in BP caused by @entity7 in aged SHR were sustained longer than reductions by @entity4 . This result indicates longer-lasting inhibition of the AT1 receptor by @entity7 than by @entity4 . CONCLUSION: ARBs ameliorated @entity6 , BP variability, and vascular senescence in aged SHR. @entity7 ameliorated the aging-related disorders better than @entity4 and was associated with longer-lasting AT1 receptor inhibition by @entity7 . Thus, the magnitude of improvement of these aging-related abnormalities differs for ARBs.

title: Blood pressure variability, impaired autonomic function and vascular senescence in aged spontaneously XXXX @entity1 are ameliorated by angiotensin blockade.

answer: @entity2


abstract: OBJECTIVE: Elderly @entity2 @entity0 are characterized by blood pressure (BP) variability, impaired autonomic function, and vascular @entity3 and stiffness. However, the mechanisms causing these conditions are unclear. The present study examined the effect of angiotensin receptor blockers (ARBs) on aged spontaneously @entity2 @entity1 (SHR). METHODS: We surgically implanted telemetry devices in SHR and WKY at the age of 15 weeks (Young) and 80 weeks (Aged). Aged SHR were orally administered either @entity7 or @entity4 once daily at 19:00  h (at the beginning of the dark period (active phase)) for 4 weeks to examine the effects on BP variability, impaired autonomic function, and vascular senescence. RESULTS: Aging and @entity2 in SHR additively caused the following: increased low frequency (LF) power of systolic BP, a decreased spontaneous baroreceptor reflex gain (sBRG), increased BP variability, increased urinary @entity5 excretion, increased vascular senescence-related beta-galactosidase positive cells and oxidative stress. Treatment with @entity7 or @entity4 significantly ameliorated these changes in aged SHR. However, @entity7 ameliorated these changes in aged SHR better than @entity4 . The reductions in BP caused by @entity7 in aged SHR were sustained longer than reductions by @entity4 . This result indicates longer-lasting inhibition of the AT1 receptor by @entity7 than by @entity4 . CONCLUSION: ARBs ameliorated @entity6 , BP variability, and vascular senescence in aged SHR. @entity7 ameliorated the aging-related disorders better than @entity4 and was associated with longer-lasting AT1 receptor inhibition by @entity7 . Thus, the magnitude of improvement of these aging-related abnormalities differs for ARBs.

title: Blood pressure variability, impaired autonomic function and vascular senescence in aged spontaneously @entity2 XXXX are ameliorated by angiotensin blockade.

answer: @entity1


abstract: @entity5 is critical for reproductive endocrinology. The aim of this study is to assess the expression patterns of @entity12 ( @entity12 ) during ovarian follicle development and to reveal the mechanism by which @entity5 affects @entity1 hormone secretion in goose granulosa cells. Transcripts of @entity12 were ubiquitous in all tested tissues, with pituitary and adrenal glands being the predominant sites. Goose ovarian follicles were divided into several groups by diameter including prehierarchical (4 to 6, 6 to 8, and 8 to 10 mm) and hierarchical (F5-F1) follicles. @entity12 gene expression was significantly higher in granulosa cells than in theca cells from follicles of 4 to 8 mm in diameter. Expression of @entity12 in granulosa cells decreased gradually as follicles developed, with fluctuating expression in F5 and F3 follicles. @entity12 mRNA in theca cells underwent a slight decrease from the 6- to 8-mm cohorts to F5 follicle and then exhibited a transient increase and declined later. In vitro experiments in cultured goose granulosa cells showed that @entity0 release was significantly stimulated, whereas @entity6 increased slightly and @entity3 decreased dramatically after @entity5 treatment. In accordance with the data for @entity2 , expression of @entity12 , @entity13 , @entity14 , @entity4 , and @entity7 were induced by the addition of @entity5 , and the concomitant changes in @entity15 , @entity10 , @entity9 , 17b-hsd, @entity11 , and 3b-hsd gene expression were seen. These results suggested that @entity5 is involved in the development of goose ovarian follicles, and @entity5 's effect on @entity1 hormone secretion could be due to altered @entity8 /steroidogenic gene expression via interaction with its receptor.

title: Role of @entity5 in the regulation of @entity8 / XXXX biosynthesis in goose granulosa cells.

answer: @entity1


abstract: @entity5 is critical for reproductive endocrinology. The aim of this study is to assess the expression patterns of @entity12 ( @entity12 ) during ovarian follicle development and to reveal the mechanism by which @entity5 affects @entity1 hormone secretion in goose granulosa cells. Transcripts of @entity12 were ubiquitous in all tested tissues, with pituitary and adrenal glands being the predominant sites. Goose ovarian follicles were divided into several groups by diameter including prehierarchical (4 to 6, 6 to 8, and 8 to 10 mm) and hierarchical (F5-F1) follicles. @entity12 gene expression was significantly higher in granulosa cells than in theca cells from follicles of 4 to 8 mm in diameter. Expression of @entity12 in granulosa cells decreased gradually as follicles developed, with fluctuating expression in F5 and F3 follicles. @entity12 mRNA in theca cells underwent a slight decrease from the 6- to 8-mm cohorts to F5 follicle and then exhibited a transient increase and declined later. In vitro experiments in cultured goose granulosa cells showed that @entity0 release was significantly stimulated, whereas @entity6 increased slightly and @entity3 decreased dramatically after @entity5 treatment. In accordance with the data for @entity2 , expression of @entity12 , @entity13 , @entity14 , @entity4 , and @entity7 were induced by the addition of @entity5 , and the concomitant changes in @entity15 , @entity10 , @entity9 , 17b-hsd, @entity11 , and 3b-hsd gene expression were seen. These results suggested that @entity5 is involved in the development of goose ovarian follicles, and @entity5 's effect on @entity1 hormone secretion could be due to altered @entity8 /steroidogenic gene expression via interaction with its receptor.

title: Role of @entity5 in the regulation of XXXX / @entity1 biosynthesis in goose granulosa cells.

answer: @entity8


abstract: @entity5 is critical for reproductive endocrinology. The aim of this study is to assess the expression patterns of @entity12 ( @entity12 ) during ovarian follicle development and to reveal the mechanism by which @entity5 affects @entity1 hormone secretion in goose granulosa cells. Transcripts of @entity12 were ubiquitous in all tested tissues, with pituitary and adrenal glands being the predominant sites. Goose ovarian follicles were divided into several groups by diameter including prehierarchical (4 to 6, 6 to 8, and 8 to 10 mm) and hierarchical (F5-F1) follicles. @entity12 gene expression was significantly higher in granulosa cells than in theca cells from follicles of 4 to 8 mm in diameter. Expression of @entity12 in granulosa cells decreased gradually as follicles developed, with fluctuating expression in F5 and F3 follicles. @entity12 mRNA in theca cells underwent a slight decrease from the 6- to 8-mm cohorts to F5 follicle and then exhibited a transient increase and declined later. In vitro experiments in cultured goose granulosa cells showed that @entity0 release was significantly stimulated, whereas @entity6 increased slightly and @entity3 decreased dramatically after @entity5 treatment. In accordance with the data for @entity2 , expression of @entity12 , @entity13 , @entity14 , @entity4 , and @entity7 were induced by the addition of @entity5 , and the concomitant changes in @entity15 , @entity10 , @entity9 , 17b-hsd, @entity11 , and 3b-hsd gene expression were seen. These results suggested that @entity5 is involved in the development of goose ovarian follicles, and @entity5 's effect on @entity1 hormone secretion could be due to altered @entity8 /steroidogenic gene expression via interaction with its receptor.

title: Role of XXXX in the regulation of @entity8 / @entity1 biosynthesis in goose granulosa cells.

answer: @entity5


abstract: OBJECTIVES: To evaluate the incidence, treatment, and outcomes of @entity2 (ARR) complicating BAV. BACKGROUND: In the transcatheter aortic valve implantation (TAVI) era, there is an increase of percutaneous balloon aortic valvuloplasty (BAV) procedures with different indications. METHODS: From the prospective BAV registry of the University of Bologna, which has enrolled @entity0 between the year 2000 and the present, we selected those who suffered intraprocedural AAR with overt hemodynamic instability. Worsening of baseline @entity2 without hemodynamic collapse, treatment of degenerated biological valve prosthesis, and BAV performed within a planned TAVI procedure were excluded. The main endpoints were in-hospital and 30-day mortality. RESULTS: Out of 1517 BAVs, we identified 26 cases of AAR (1.7%). This complication occurred in 80.8% of cases after one or two balloon inflations. Mean transaortic gradient decreased from 50.6      19.3 to 26.0      14.4 mm  Hg (p  <  0.01). In 8(30.8%) @entity0 , AAR spontaneously resolved within few minutes; in 18 cases, the operators had to perform a rescue maneuver to reposition a valve leaflet got stuck in the opening position (this maneuver was successful in 13/18 of the cases, 72.2%). Out of 5 persistent AAR, 3 were managed with emergency TAVI or surgery, while 2 were unresolved. In-hospital mortality was 15.4% (n  =  4), whereas no more @entity1 occurred up to 30 days. CONCLUSIONS: AAR is a fearsome complication of BAV and portends a grim prognosis. In some cases, it can be resolved with appropriate technical maneuvers; in others, a rescue TAVI or surgical valve replacement may be necessary.    2015 Wiley Periodicals, Inc.

title: Incidence, treatment, and outcome of acute XXXX complicating percutaneous balloon aortic valvuloplasty.

answer: @entity2


abstract: BACKGROUND: WHO guidelines advocate breastfeeding for 6 months, and EAACI guideline recommends exclusive breastfeeding for 4-6 months. However, evidence for breastfeeding to prevent @entity3 and @entity0 is conflicting. We examined whether following recommended breastfeeding guidelines alters the long-term risks of @entity3 , @entity2 , @entity4 or @entity1 . METHODS: The effect of nonexclusive (0, >0-6, >6 months) and exclusive breastfeeding (0, >0-4, >4 months) on repeated measures of @entity3 (10, 18 years), @entity2 , @entity4 , and @entity1 (1-or-2, 4, 10, 18 years) risks was estimated in the IoW cohort (n = 1456) using log-linear models with generalized estimating equations. The Food Allergy and Intolerance Research (FAIR) cohort (n = 988), also from the IoW, was examined to replicate results. RESULTS: Breastfeeding (any or exclusive) had no effect on @entity3 and @entity0 in the IoW cohort. In the FAIR cohort, any breastfeeding for >0-6 months protected against @entity3 at 10 years (RR = 0.50, 95% CI = 0.32-0.79, P = 0.003), but not other outcomes, whilst exclusive breastfeeding for >4 months protected against repeated @entity4 (RR = 0.36, 95% CI = 0.18-0.71, P = 0.003). Longer breastfeeding was protective against late-onset wheeze in the IoW cohort. CONCLUSION: The protective effects of nonexclusive and exclusive breastfeeding against long-term allergic outcomes were inconsistent between these colocated cohorts, agreeing with previous observations of heterogeneous effects. Although breastfeeding should be recommended for other health benefits, following breastfeeding guidelines did not appear to afford a consistent protection against long-term @entity3 , @entity2 , @entity4 or @entity1 . Further research is needed into the long-term effects of breastfeeding on @entity0 .

title: Evaluating the efficacy of breastfeeding guidelines on long-term outcomes for XXXX .

answer: @entity0


abstract: UNASSIGNED: Introduction @entity0 undergoing the Norwood operation consume considerable healthcare resources; however, detailed information regarding factors impacting hospitalisation costs is lacking. We evaluated the association of @entity1 with hospital costs. METHODS: In the present study, we utilised a unique data set consisting of prospectively collected clinical data from the Pediatric Heart Network Single Ventricle Reconstruction trial linked at the @entity0 level with cost data for 10 hospitals participating in the @entity0 's Hospital Association Case Mix database during the trial period. The relationship between complications and cost was modelled using linear regression, accounting for the skewed distribution of cost, adjusting for within-centre clustering and baseline @entity0 characteristics. RESULTS: A total of 334 eligible Norwood records (97.5%) were matched between data sets. Overall, 82% suffered from at least one complication (median 2; with a range from 0 to 33). Those with complications had longer postoperative length of stay (25 versus 12 days, p<0.001), more total ventilator days (7 versus 5 days, p<0.001), and higher in-hospital mortality (17.6 versus 3.4%, p<0.006). Mean adjusted hospital cost in those with a complication was  190,689 (95% CI  111,344- 326,577) versus  120,584 (95% CI  69,246- 209,983) in those without complications (p=0.002). Costs increased with the number of complications (1-2 complications= 132,800 versus 3-4 complications= 182,353 versus    5 complications= 309,372 [p<0.001]). CONCLUSIONS: This merged data set of clinical trial and cost data demonstrated that @entity1 are common following the Norwood operation and are associated with worse clinical outcomes and higher costs. Efforts to reduce complications in this population may lead to improved outcomes and cost savings.

title: Impact of XXXX on hospital costs following the Norwood operation.

answer: @entity1


abstract: Understanding the interfacial properties of soft @entity0 ( @entity1 ) microgels covering an oil-water interface is essential for engineering stimuli-responsive emulsions stabilized by soft microgel particles. This study presents a systematic study on the interfacial properties of the PNIPAM-microgel-laden @entity2 -water interface as a function of temperature. We measured the interfacial tensions as well as dilatational rheology properties of the microgel-laden @entity2 -water interface using a pendant drop tensiometer. From fresh droplet experiments, the anomalous interfacial tension minima of the microgels covered oil-water interface were observed around the volume phase transition temperature (VPTT) of the PNIPAM microgels. Such interfacial tension minima are observable regardless of the microgel aggregates. Both dynamic and static parameters contributed to the observed interfacial tension minima around VPTT. The PNIPAM microgel deformability dynamically dominated the microgel spreading at the @entity2 -water interface in the early states, while PNIPAM microgel packing and interactions dominated the final static equilibrium states. Combining the interfacial tension and the dilatational rheology properties, we propose that the microgels would approach three distinctive states at temperatures below, around, and above VPTT at the @entity2 -water interface. Single droplet experiments further demonstrate that there exists an irreversible transition among these three states. The results of this study deepen our understanding of soft, porous, and deformable microgels' behaviors at the oil-water interface and have important implications for engineering microgels as stimuli-responsive emulsion stabilizers.

title: XXXX microgels at the oil-water interface: temperature effect.

answer: @entity0


abstract: AIM: The aim of this study was to evaluate the impact of surgical staging in stage I clear cell @entity1 (CCC). METHODS: We performed a retrospective review of 165 @entity0 with stage I CCC treated with optimal or nonoptimal staging surgery. RESULTS: The median follow-up period in this study was 67 months. No significant difference was detected in @entity2 ( @entity2 ) or @entity2 ( @entity2 ) between @entity0 optimally and nonoptimally staged ( @entity2 : P = 0.434; @entity2 : P = 0.759). The estimated 5-year @entity2 and @entity2 rates were 92.1% and 95.3% in @entity0 with stages IA/ @entity4 and 81.0% and 83.7% in stages @entity3 /IC3, respectively. The multivariate analysis indicated that stages @entity3 /IC3 predicted worse @entity2 and @entity2 than stages IA/ @entity4 in stage I CCC @entity0 ( @entity2 : P = 0.011; @entity2 : P = 0.011). Subsequently, we investigated the impact of surgical staging, respectively, in stages IA/ @entity4 and stages @entity3 /IC3. Significant differences were observed in PFS and @entity2 between @entity0 optimally and nonoptimally staged with stages IA/ @entity4 ( @entity2 : P = 0.021; @entity2 : P = 0.024), but no significant difference was found in those with stages @entity3 /IC3. The multivariate analysis indicated that nonoptimal staging surgery predicted worse @entity2 than the optimal staging surgery in stages IA/ @entity4 CCC @entity0 (P = 0.033). In addition, we investigated the impact of surgical staging for stages IA/ @entity4 in the adjuvant chemotherapy group. The 5-year @entity2 and @entity2 rates in @entity0 optimally and nonoptimally staged with stages IA/ @entity4 in the adjuvant chemotherapy group were 97.8% and 100%, and 85.2% and 89.4%, respectively. The multivariate analysis indicated that nonoptimal staging surgery predicted worse @entity2 than the optimal staging surgery for stages IA/ @entity4 @entity0 in the adjuvant chemotherapy group (P = 0.019). CONCLUSIONS: The prognosis for @entity0 with stage 1A/ @entity4 is very good. Surgical staging category was the only independent prognostic factor for @entity2 in stages IA/ @entity4 CCC.

title: Impact of surgical staging in stage I clear cell XXXX .

answer: @entity1


abstract: CONTEXT: Overall, 4-10% of @entity0 with @entity4 ( @entity4 ) present with @entity1 thrombus. It is uncertain which surgical technique is best for these @entity0 . Appraisal of outcomes with differing techniques would guide practice. OBJECTIVE: To systematically review relevant literature comparing the outcomes of different surgical therapies and approaches in treating vena caval thrombus (VCT) from nonmetastatic @entity4 . EVIDENCE ACQUISITION: Relevant databases (Medline, Embase, and the Cochrane Library) were searched to identify relevant comparative studies. Risk of bias and confounding assessments were performed. A narrative synthesis of the evidence was presented. EVIDENCE SYNTHESIS: The literature search identified 824 articles. Fourteen studies reporting on 2262 @entity0 were included. No distinct surgical method was superior for the excision of VCT, although the method appeared to be dependent on @entity1 thrombus level. Minimal access techniques appeared to have better perioperative and recovery outcomes than traditional median sternotomy, but the impact on oncologic outcomes is unknown. @entity2 did not offer any oncologic benefits and instead resulted in significantly worse perioperative and recovery outcomes, including possibly higher perioperative mortality. The comparison of cardiopulmonary bypass versus no cardiopulmonary bypass showed no differences in oncologic outcomes. Overall, there were high risks of bias and confounding. CONCLUSIONS: The evidence base, although derived from retrospective case series and complemented by expert opinion, suggests that @entity0 with nonmetastatic @entity4 and VCT and acceptable performance status should be considered for surgical intervention. Despite a robust review, the findings were associated with uncertainty due to the poor quality of primary studies available. The most efficacious surgical technique remains unclear. @entity0 SUMMARY: We examined the literature on the benefits of @entity3 that have spread to neighbouring veins. The results suggest such surgery, although challenging and associated with high risk of complications, appears to be feasible and effective and should be contemplated for suitable @entity0 if possible; however, many uncertainties remain due to the poor quality of the data.

title: Systematic Review of Surgical Management of Nonmetastatic XXXX with Vena Caval Thrombus.

answer: @entity4


abstract: UNASSIGNED: @entity0 ( @entity3 ) is a @entity1 that exerts anti  -arrhythmic effects. However, its potential effects on ion channels have remained elusive. The aim of the present study was to investigate the effects of @entity3 on @entity2  channels in HEK293  cells. The current of @entity2 channels (Ikur) in HEK293  cells was recorded using the whole  -cell patch  -clamp technique and the expression of the @entity2 protein was measured using western blot analysis 24  h after treatment with @entity3 . The results showed that 5    M @entity3 significantly reduced Ikur from 215.04  40.59 to 77.72  17.94  pA/pF (P<0.05; n=5). @entity3 increased the current suppression from 0 to 0.31  0.12 and 0.55  0.11 over 5 or 20  min, respectively. In addition, Ikur decreased from 376.23  1.30 to 270.19  4.28  pA/pF when the frequency was increased from 0.5 to 4  Hz in HEK293  cells treated with 10    M @entity3 for 5  min. Furthermore, @entity3 reduced @entity2 protein expression in a dose  -dependent manner. These results demonstrated that @entity3 inhibited Ikur and the expression of @entity2 in HEK293  cells in a dose  -, time  - and frequency  -dependent manner. These observations partly explained the mechanisms by which @entity3 exerts anti  -arrhythmic effect.

title: @entity0 inhibits XXXX channels in HEK293 cells.

answer: @entity2


abstract: UNASSIGNED: @entity0 ( @entity3 ) is a @entity1 that exerts anti  -arrhythmic effects. However, its potential effects on ion channels have remained elusive. The aim of the present study was to investigate the effects of @entity3 on @entity2  channels in HEK293  cells. The current of @entity2 channels (Ikur) in HEK293  cells was recorded using the whole  -cell patch  -clamp technique and the expression of the @entity2 protein was measured using western blot analysis 24  h after treatment with @entity3 . The results showed that 5    M @entity3 significantly reduced Ikur from 215.04  40.59 to 77.72  17.94  pA/pF (P<0.05; n=5). @entity3 increased the current suppression from 0 to 0.31  0.12 and 0.55  0.11 over 5 or 20  min, respectively. In addition, Ikur decreased from 376.23  1.30 to 270.19  4.28  pA/pF when the frequency was increased from 0.5 to 4  Hz in HEK293  cells treated with 10    M @entity3 for 5  min. Furthermore, @entity3 reduced @entity2 protein expression in a dose  -dependent manner. These results demonstrated that @entity3 inhibited Ikur and the expression of @entity2 in HEK293  cells in a dose  -, time  - and frequency  -dependent manner. These observations partly explained the mechanisms by which @entity3 exerts anti  -arrhythmic effect.

title: XXXX inhibits @entity2 channels in HEK293 cells.

answer: @entity0


abstract: STUDY DESIGN: This is a retrospective comparative cohort study. OBJECTIVE: To compare the outcomes of @entity0 with symptomatic @entity1 ( @entity1 ) treated with full-endoscopic cervical discectomy (FECD) using the anterior approach with those treated with the posterior approach. SUMMARY OF BACKGROUND DATA: The optimal FECD surgical approach for @entity1 remains controversial. METHODS: From March 2010 to July 2012, a total of 84 consecutive @entity0 with symptomatic single-level @entity1 who underwent FECD using the anterior approach (42 @entity0 ) or the posterior approach (42 @entity0 ) were enrolled. @entity0 were assessed neurologically before surgery and followed up at regular outpatient visits. The clinical outcomes were evaluated using the visual analogue scale and the modified MacNab criteria. Radiographical follow-up included the static and dynamic cervical plain radiographs, computed tomographic scans, and magnetic resonance images. RESULTS: In both groups, shorter mean operative time (63.5 min vs. 78.5 min), increased mean volume of disc removal (0.6 g vs. 0.3 g), larger mean decrease in the final postoperative mean intervertebral vertical height (1.0 mm vs. 0.5 mm), and longer mean hospital stay (4.9 d vs. 4.5 d) were observed in the anterior full-endoscopic cervical discectomy group. Postoperatively, the clinical outcomes of the 2 approaches were significantly improved, but the differences between the 2 approaches were not significant (P = 0.211 and P = 0.257, respectively). Four surgery-related complications were observed among all enrolled @entity0 (complications in each group were 2; overall 4 of 84, 4.8%). CONCLUSION: In our study, the clinical outcomes between the 2 approaches did not differ significantly. Nevertheless, posterior full-endoscopic cervical discectomy may be preferable when considering the volume of disc removal, length of hospital stay, and the postoperative radiographical changes. As an efficacious supplement to traditional open surgery, FECD is a reliable alternative treatment of @entity1 and its optimal approach remains open to discussion. LEVEL OF EVIDENCE: 3.

title: Anterior or posterior approach of full-endoscopic cervical discectomy for XXXX ? A comparative cohort study.

answer: @entity1


abstract: AIMS: Although @entity4 ( @entity4 ) is a risk factor for malignant transformation and future development of @entity2 / @entity1 , grade is not incorporated in the Dutch guidelines for colonoscopy surveillance, partly due to presumed interobserver variability. In a nationwide cohort of @entity5 , we analysed the interlaboratory variability in the grading of @entity3 in daily practice. METHODS AND RESULTS: Using the Dutch Pathology Registry (PALGA), all synoptically reported classic @entity2 in The Netherlands in 2013 were identified. Proportion of @entity2 with @entity4 was determined for biopsies and polypectomies and compared between 37 laboratories by multivariable logistic regression analyses. In total, 21,030 colonoscopies of 20,270 @entity0 were included. @entity4 was reported in 530 (3.6%) out of 14,866 @entity2 diagnosed on biopsies (range between laboratories: 0%-13.6%) and in 983 (11.8%) out of 8,346 @entity2 diagnosed on polypectomies (range 3.1%-42.9%). After adjustment for case mix, thirteen (35%) laboratories reported a significantly lower or higher frequency of @entity4 than average. CONCLUSIONS: We observed considerable interlaboratory variation in the grading of @entity3 in @entity5 , which could only be partly explained by differences in case mix. Therefore, better standardization of grading criteria is needed before grade of @entity3 can usefully be incorporated in colonoscopy surveillance guidelines. This article is protected by copyright. All rights reserved.

title: Interlaboratory variability in the grading of @entity3 in a nationwide cohort of XXXX .

answer: @entity5


abstract: AIMS: Although @entity4 ( @entity4 ) is a risk factor for malignant transformation and future development of @entity2 / @entity1 , grade is not incorporated in the Dutch guidelines for colonoscopy surveillance, partly due to presumed interobserver variability. In a nationwide cohort of @entity5 , we analysed the interlaboratory variability in the grading of @entity3 in daily practice. METHODS AND RESULTS: Using the Dutch Pathology Registry (PALGA), all synoptically reported classic @entity2 in The Netherlands in 2013 were identified. Proportion of @entity2 with @entity4 was determined for biopsies and polypectomies and compared between 37 laboratories by multivariable logistic regression analyses. In total, 21,030 colonoscopies of 20,270 @entity0 were included. @entity4 was reported in 530 (3.6%) out of 14,866 @entity2 diagnosed on biopsies (range between laboratories: 0%-13.6%) and in 983 (11.8%) out of 8,346 @entity2 diagnosed on polypectomies (range 3.1%-42.9%). After adjustment for case mix, thirteen (35%) laboratories reported a significantly lower or higher frequency of @entity4 than average. CONCLUSIONS: We observed considerable interlaboratory variation in the grading of @entity3 in @entity5 , which could only be partly explained by differences in case mix. Therefore, better standardization of grading criteria is needed before grade of @entity3 can usefully be incorporated in colonoscopy surveillance guidelines. This article is protected by copyright. All rights reserved.

title: Interlaboratory variability in the grading of XXXX in a nationwide cohort of @entity5 .

answer: @entity3


abstract: UNASSIGNED: The purpose of this study was to estimate and examine ways to improve the reliability of change scores on the @entity2 Assessment Scale, Cognitive Subtest ( @entity3 -Cog). The sample, provided by the @entity2 Neuroimaging Initiative, included individuals with @entity2 ( @entity2 ) (n  =  153) and individuals with @entity1 ( @entity1 ) (n  =  352). All @entity0 were administered the @entity3 -Cog at baseline and 1 year, and change scores were calculated as the difference in scores over the 1-year period. Three types of change score reliabilities were estimated using multivariate generalizability. Two methods to increase change score reliability were evaluated: reweighting the subtests of the scale and adding more subtests. Reliability of @entity3 -Cog change scores over 1 year was low for both the @entity2 sample (ranging from .53 to .64) and the @entity1 sample (.39 to .61). Reweighting the change scores from the @entity2 sample improved reliability (.68 to .76), but lengthening provided no useful improvement for either sample. The @entity1 change scores had low reliability, even with reweighting and adding additional subtests. The @entity3 -Cog scores had low reliability for measuring change. Researchers using the @entity3 -Cog should estimate and report reliability for their use of the change scores. The @entity3 -Cog change scores are not recommended for assessment of meaningful clinical change.

title: Examining the reliability of XXXX -Cog change scores.

answer: @entity3


abstract: PURPOSE: We aimed to use a noninvasive method for quantifying T1 values of chronic @entity3 scar by cardiac magnetic resonance imaging (MRI), and determine its diagnostic performance. MATERIALS AND METHODS: We performed cardiac MRI on 29 consecutive @entity0 with known @entity2 ( @entity2 ) on 3.0 Tesla MRI scanner. An unenhanced T1 mapping technique was used to calculate T1 relaxation time of @entity1 , and its diagnostic performance was evaluated. @entity4 was identified by delayed contrast-enhancement (DE) MRI and T2-weighted images. Sensitivity, specificity, and accuracy values were calculated for T1 mapping using DE images as the gold standard. RESULTS: Four hundred and forty-two segments were analyzed in 26 @entity0 . While myocardial chronic scar was demonstrated in 45 segments on DE images, T1 mapping MRI showed a chronic scar area in 54 segments. T1 relaxation time was higher in chronic scar tissue, compared with remote areas (1314  98 ms vs. 1099  90 ms, P < 0.001). Therefore, increased T1 values were shown in areas of myocardium colocalized with areas of DE and normal signal on T2-weighted images. There was a significant correlation between T1 mapping and DE images in evaluation of myocardial wall injury extent (P < 0.05). We calculated sensitivity, specificity, and accuracy as 95.5%, 97%, and 96%, respectively. CONCLUSION: The results of the present study reveal that T1 mapping MRI combined with T2-weighted images might be a feasible imaging modality for detecting chronic @entity3 scar tissue.

title: Quantitative evaluation of ischemic XXXX by unenhanced T1 mapping using 3.0 Tesla MR scanner.

answer: @entity1


abstract: PURPOSE: This study aimed to determine the ability of a set of physical fitness tests to discriminate presence or absence of @entity1 in @entity0 . METHODS: The sample comprised 487 @entity0 with @entity1 (52.1    8 yr) and 250 control @entity0 (49.3    9 yr). We assessed physical fitness using the arm curl, 30-s chair stand, handgrip strength, 8-ft up and go, 6-min walk, chair sit and reach, and the back scratch tests. The revised @entity1 impact questionnaire was used to assess @entity1 severity and symptomatology. RESULTS: @entity0 with @entity1 performed worse than control @entity0 in all the fitness tests studied (all, P < 0.001). The receiver operating characteristic analysis showed that all the fitness tests were able to discriminate between presence and absence of @entity1 (all, P < 0.001). The area under the curve ranged from 0.708 to 0.910 (all, P < 0.001). Among the fitness tests studied, the arm curl test, followed by the 30-s chair-stand and handgrip strength tests, showed the highest capacity discriminating between the presence and absence of @entity1 . An arm curl test score of <20 repetitions was associated with increased odds of having @entity1 (odds ratio (OR), 35.6; 95% confidence interval, 12.6-101) in @entity0 age 35-44 yr. An arm curl test score of <16 repetitions was associated with increased odds of having @entity1 (OR, 23.7; 95% confidence interval, 10.3-54.0) in @entity0 age 35-44 yr. In the group of @entity0 age 55-65 yr, the highest OR was observed for the handgrip strength test and the odds of having @entity1 was 17 times greater than that in @entity0 who performed less than 19 kg. CONCLUSIONS: The arm curl, 30-s chair stand, and handgrip strength tests powerfully discriminated @entity0 with @entity1 from healthy @entity0 . Identification of @entity0 who fail to meet the suggested standards can help to easily, quickly, and cheaply rule out the presence of the disease, especially in primary care settings.

title: Fitness Testing in the XXXX Diagnosis: The al-  ndalus Project.

answer: @entity1


abstract: Aims. Young adults with early @entity1 want to pursue normal roles - education and employment. This paper summarises the empirical literature on the effectiveness of early intervention programmes for employment and education outcomes. Methods. We conducted a systematic review of employment/education outcomes for early intervention programmes, distinguishing three programme types: (1) those providing supported employment, (2) those providing unspecified vocational services and (3) those without vocational services. We summarised findings for 28 studies. Results. Eleven studies evaluated early intervention programmes providing supported employment. In eight studies that reported employment outcomes separately from education outcomes, the employment rate during follow-up for supported employment @entity0 was 49%, compared with 29% for @entity0 receiving usual services. The two groups did not differ on enrolment in education. In four controlled studies, meta-analysis showed that the employment rate for supported employment @entity0 was significantly higher than for control @entity0 , odds ratio  =  3.66 [1.93-6.93], p  <  0.0001. Five studies (four descriptive and one quasi-experimental) of early intervention programmes evaluating unspecified vocational services were inconclusive. Twelve studies of early intervention programmes without vocational services were methodologically heterogeneous, using diverse methods for evaluating vocational/educational outcomes and precluding a satisfactory meta-analytic synthesis. Among studies with comparison groups, 7 of 11 (64%) reported significant vocational/education outcomes favouring early intervention over usual services. Conclusions. In early intervention programmes, supported employment moderately increases employment rates but not rates of enrolment in education. These improvements are in addition to the modest effects early programmes alone have on vocational/educational outcomes compared with usual services.

title: Employment and educational outcomes in early intervention programmes for early XXXX : a systematic review.

answer: @entity1


abstract: INTRODUCTION: Atrioesophageal @entity1 (AEF) is a rare but devastating complication of radiofrequency catheter ablation (RFCA) of @entity3 ( @entity3 ). Surgical repair and esophageal stents are available treatment options for AEF. We report outcomes of these 2 management strategies. METHODS: Nine @entity0 with AEF post-RFCA for @entity3 were included in this study. AEF was diagnosed based on symptoms and chest CT imaging. Of the 9 @entity0 , 5 received stents and 4 underwent surgical repair of @entity1 . RESULTS: @entity3 ablation was performed under general anesthesia (n = 4) or conscious sedation (n = 5). During ablation, RF power was maintained between 25 and 35 Watts in areas close to the esophagus and energy delivery discontinued when esophageal temperature reached 38   C. Seven @entity0 underwent ablation with 3.5-mm open-irrigated catheter, 1 with 8-mm nonirrigated catheter, and 1 had surgical epicardial ablation. Seven @entity0 received proton pump inhibitor and sucralfate before and after procedure. AEF symptoms developed within 2   6 weeks from ablation. Esophageal stenting was performed in 5 @entity0 (median age 58 years, median time from RFCA 4 weeks) and 4 underwent surgical repair (median age 54 years, median time from RFCA 4 weeks) within 2   4 hours from diagnosis. All 5 @entity0 receiving stents died within 1 week of the procedure due to @entity4 , @entity2 , or @entity5 . On the other hand, the 4 @entity0 that received surgical repair were alive at median follow-up of 2.1 years (P = 0.005). CONCLUSIONS: Esophageal stenting should be discouraged and prompt surgical repair is crucial for survival in @entity0 with @entity1 .

title: Outcomes of XXXX following catheter ablation of @entity3 treated with surgical repair versus esophageal stenting.

answer: @entity1


abstract: INTRODUCTION: Atrioesophageal @entity1 (AEF) is a rare but devastating complication of radiofrequency catheter ablation (RFCA) of @entity3 ( @entity3 ). Surgical repair and esophageal stents are available treatment options for AEF. We report outcomes of these 2 management strategies. METHODS: Nine @entity0 with AEF post-RFCA for @entity3 were included in this study. AEF was diagnosed based on symptoms and chest CT imaging. Of the 9 @entity0 , 5 received stents and 4 underwent surgical repair of @entity1 . RESULTS: @entity3 ablation was performed under general anesthesia (n = 4) or conscious sedation (n = 5). During ablation, RF power was maintained between 25 and 35 Watts in areas close to the esophagus and energy delivery discontinued when esophageal temperature reached 38   C. Seven @entity0 underwent ablation with 3.5-mm open-irrigated catheter, 1 with 8-mm nonirrigated catheter, and 1 had surgical epicardial ablation. Seven @entity0 received proton pump inhibitor and sucralfate before and after procedure. AEF symptoms developed within 2   6 weeks from ablation. Esophageal stenting was performed in 5 @entity0 (median age 58 years, median time from RFCA 4 weeks) and 4 underwent surgical repair (median age 54 years, median time from RFCA 4 weeks) within 2   4 hours from diagnosis. All 5 @entity0 receiving stents died within 1 week of the procedure due to @entity4 , @entity2 , or @entity5 . On the other hand, the 4 @entity0 that received surgical repair were alive at median follow-up of 2.1 years (P = 0.005). CONCLUSIONS: Esophageal stenting should be discouraged and prompt surgical repair is crucial for survival in @entity0 with @entity1 .

title: Outcomes of @entity1 following catheter ablation of XXXX treated with surgical repair versus esophageal stenting.

answer: @entity3


abstract: CONTEXT: Hormone secretion by functioning @entity6 is characterized by increased basal (nonpulsatile) secretion, enhanced pulse frequency, amplified pulse mass, and @entity2 . OBJECTIVE: The objective of the study was to quantify (subtle) abnormalities of hormone secretion by @entity6 and the influence of selective pituitary surgery and suppressive medications on these parameters. METHODS: Approximate entropy (ApEn) was quantified with a refined algorithm, @entity9 by a new method to evaluate sudden short-lived increases in hormone levels, and pulsing regularity, determined with a fully automated deconvolution program. These 3 distinct measures of secretory disruption were compared in untreated and treated @entity0 with @entity7 , @entity8 , and @entity4 together with matching profiles in healthy controls. RESULTS: ApEn and @entity9 were markedly increased in all untreated @entity0 groups and normalized after pituitary surgery in @entity7 and @entity4 . In contrast, hormone-suppressive medical treatment in @entity7 and @entity8 did not normalize ApEn. Spikiness normalized in acromegalic @entity0 but not in @entity8 . GH and @entity5 pulsing regularity was elevated in @entity7 and @entity4 , respectively, and normalized after surgery. Medical treatment caused normalization of pulsing regularity in @entity7 but not in @entity8 @entity0 . CONCLUSION: This study extends the understanding of disorganized hormone secretion by hyperfunctioning @entity6 . The new findings are increased @entity9 in all 3 @entity1 groups and increased pulsing regularity in GH- and ACTH-secreting @entity3 . The mechanisms behind the marked pattern irregularity and the selective normalization by surgical and medical therapies are not established yet but may include diminished feedback signaling in addition to the anatomical and functional disorganization of intrapituitary cell networks.

title: Hormone secretion by XXXX is characterized by @entity2 and @entity9 but more regular pulsing.

answer: @entity6


abstract: CONTEXT: Hormone secretion by functioning @entity6 is characterized by increased basal (nonpulsatile) secretion, enhanced pulse frequency, amplified pulse mass, and @entity2 . OBJECTIVE: The objective of the study was to quantify (subtle) abnormalities of hormone secretion by @entity6 and the influence of selective pituitary surgery and suppressive medications on these parameters. METHODS: Approximate entropy (ApEn) was quantified with a refined algorithm, @entity9 by a new method to evaluate sudden short-lived increases in hormone levels, and pulsing regularity, determined with a fully automated deconvolution program. These 3 distinct measures of secretory disruption were compared in untreated and treated @entity0 with @entity7 , @entity8 , and @entity4 together with matching profiles in healthy controls. RESULTS: ApEn and @entity9 were markedly increased in all untreated @entity0 groups and normalized after pituitary surgery in @entity7 and @entity4 . In contrast, hormone-suppressive medical treatment in @entity7 and @entity8 did not normalize ApEn. Spikiness normalized in acromegalic @entity0 but not in @entity8 . GH and @entity5 pulsing regularity was elevated in @entity7 and @entity4 , respectively, and normalized after surgery. Medical treatment caused normalization of pulsing regularity in @entity7 but not in @entity8 @entity0 . CONCLUSION: This study extends the understanding of disorganized hormone secretion by hyperfunctioning @entity6 . The new findings are increased @entity9 in all 3 @entity1 groups and increased pulsing regularity in GH- and ACTH-secreting @entity3 . The mechanisms behind the marked pattern irregularity and the selective normalization by surgical and medical therapies are not established yet but may include diminished feedback signaling in addition to the anatomical and functional disorganization of intrapituitary cell networks.

title: Hormone secretion by @entity6 is characterized by XXXX and @entity9 but more regular pulsing.

answer: @entity2


abstract: CONTEXT: Hormone secretion by functioning @entity6 is characterized by increased basal (nonpulsatile) secretion, enhanced pulse frequency, amplified pulse mass, and @entity2 . OBJECTIVE: The objective of the study was to quantify (subtle) abnormalities of hormone secretion by @entity6 and the influence of selective pituitary surgery and suppressive medications on these parameters. METHODS: Approximate entropy (ApEn) was quantified with a refined algorithm, @entity9 by a new method to evaluate sudden short-lived increases in hormone levels, and pulsing regularity, determined with a fully automated deconvolution program. These 3 distinct measures of secretory disruption were compared in untreated and treated @entity0 with @entity7 , @entity8 , and @entity4 together with matching profiles in healthy controls. RESULTS: ApEn and @entity9 were markedly increased in all untreated @entity0 groups and normalized after pituitary surgery in @entity7 and @entity4 . In contrast, hormone-suppressive medical treatment in @entity7 and @entity8 did not normalize ApEn. Spikiness normalized in acromegalic @entity0 but not in @entity8 . GH and @entity5 pulsing regularity was elevated in @entity7 and @entity4 , respectively, and normalized after surgery. Medical treatment caused normalization of pulsing regularity in @entity7 but not in @entity8 @entity0 . CONCLUSION: This study extends the understanding of disorganized hormone secretion by hyperfunctioning @entity6 . The new findings are increased @entity9 in all 3 @entity1 groups and increased pulsing regularity in GH- and ACTH-secreting @entity3 . The mechanisms behind the marked pattern irregularity and the selective normalization by surgical and medical therapies are not established yet but may include diminished feedback signaling in addition to the anatomical and functional disorganization of intrapituitary cell networks.

title: Hormone secretion by @entity6 is characterized by @entity2 and XXXX but more regular pulsing.

answer: @entity9


abstract: PURPOSE: To report our experience in the treatment of @entity3 of the conjunctiva using topical bevacizumab. METHODS: Ten eyes of 10 @entity0 with conjunctival @entity1 received 25 mg/mL bevacizumab topically. Changes in the lesions were documented weekly using digital photography. After topical treatment, excisional biopsy was performed. RESULTS: The mean age of the @entity0 was 60.5    12 (33-77) years. The mean duration of topical treatment was 7.8    1.3 (5-14) weeks. The size and vascularity of the @entity1 reduced weekly. All @entity0 underwent excisional biopsy, cryotherapy, and amnion membrane transplantation. The histopathologic diagnosis of the lesions was @entity2 in situ. No recurrence was observed during the follow-up of @entity0 for 6 months. CONCLUSIONS: Topical bevacizumab is an effective treatment to reduce the @entity1 size before surgery and may be a good alternative for adjuvant therapy of @entity4 .

title: Use of topical bevacizumab for XXXX .

answer: @entity3


abstract: INTRODUCTION: Different dengue virus (DENV) serotypes have been associated with greater epidemic potential. In turn, the increased frequency in cases of severe forms of dengue has been associated with the cocirculation of several serotypes. Because Colombia is a country with an endemic presence of all four DENV serotypes, the aim of this study was to evaluate the in vivo and in vitro replication of the DENV-2 and DENV-3 strains under individual @entity1 and coinfection conditions. METHODOLOGY: C6/36HT cells were infected with the two strains individually or simultaneously (coinfection). Replication capacity was evaluated by RT-qPCR, and the effects on cell viability were assessed with an @entity0 ( @entity3 ) assay. Additionally, @entity4 mosquitoes were artificially fed the two strains of each serotype individually or simultaneously. The viral genomes were quantified by RT-qPCR and the survival of the infected mosquitoes was compared to that of uninfected controls. RESULTS: In single infections, three strains significantly affected C6/36HT cell viability, but no significant differences were found in the replication capacities of the strains of the same serotype. In the in vivo infections, mosquito survival was not affected, and no significant differences in replication between strains of the same serotype were found. Finally, in @entity2 , serotype 2 replicated with a thousandfold greater efficiency than serotype 3 did both in vitro and in vivo. CONCLUSIONS: Due to the cocirculation of serotypes in endemic regions, further studies of @entity2 in a natural environment would further an understanding of the transmission dynamics that affect DENV @entity1 epidemiology.

title: Differential replication of dengue virus serotypes 2 and 3 in XXXX of C6/36 cells and @entity4 mosquitoes.

answer: @entity2


abstract: INTRODUCTION: Different dengue virus (DENV) serotypes have been associated with greater epidemic potential. In turn, the increased frequency in cases of severe forms of dengue has been associated with the cocirculation of several serotypes. Because Colombia is a country with an endemic presence of all four DENV serotypes, the aim of this study was to evaluate the in vivo and in vitro replication of the DENV-2 and DENV-3 strains under individual @entity1 and coinfection conditions. METHODOLOGY: C6/36HT cells were infected with the two strains individually or simultaneously (coinfection). Replication capacity was evaluated by RT-qPCR, and the effects on cell viability were assessed with an @entity0 ( @entity3 ) assay. Additionally, @entity4 mosquitoes were artificially fed the two strains of each serotype individually or simultaneously. The viral genomes were quantified by RT-qPCR and the survival of the infected mosquitoes was compared to that of uninfected controls. RESULTS: In single infections, three strains significantly affected C6/36HT cell viability, but no significant differences were found in the replication capacities of the strains of the same serotype. In the in vivo infections, mosquito survival was not affected, and no significant differences in replication between strains of the same serotype were found. Finally, in @entity2 , serotype 2 replicated with a thousandfold greater efficiency than serotype 3 did both in vitro and in vivo. CONCLUSIONS: Due to the cocirculation of serotypes in endemic regions, further studies of @entity2 in a natural environment would further an understanding of the transmission dynamics that affect DENV @entity1 epidemiology.

title: Differential replication of dengue virus serotypes 2 and 3 in @entity2 of C6/36 cells and XXXX mosquitoes.

answer: @entity4


abstract: OBJECTIVES: To assess the efficacy and safety of golimumab in the 140 @entity0 included in Spain as the first part of the GO-MORE trial, a multinational study involving @entity0 with active @entity2 ( @entity2 ) despite treatment with different disease-modifying antirheumatic drugs (DMARDs). @entity0 AND METHODS: The @entity0 received subcutaneous golimumab 50mg once a month during 6 months. The primary endpoint was the percentage of individuals with a good or moderate EULAR DAS28-ESR response after 6 months of treatment. RESULTS: A total of 140 @entity0 were included. Of these, 76.4% had very active disease (DAS28-ESR>5.1). 76.4% were taking @entity3 , 40.0% other DMARDs in monotherapy or combined, and 65.0% received @entity1 . After 6 months, 82.9% of the @entity0 showed a good or moderate EULAR response, 41.4% had low disease activity, and 30.7% were in remission. The percentage of responders one month after the first dose was 69.3%. The efficacy was similar in @entity0 treated with @entity3 or other DMARDs, with different @entity3 doses, with or without @entity1 , or in subjects who had failed one or more DMARDs. The response to golimumab was observed from the first dose. Golimumab was well tolerated and its safety profile was consistent with the findings of previous studies. Serious adverse events were reported in 11 @entity0 (7.9%). CONCLUSION: The addition of subcutaneous golimumab 50mg once a month to different DMARDs in @entity0 with active @entity2 yielded a moderate or good response after 6 months in 82.9% of the cases. The response was observed early, from the start of the second month, after a single dose of golimumab.

title: Efficacy and safety of golimumab as add-on therapy to disease-modifying antirheumatic drugs in XXXX : Results of the GO-MORE study in Spain.

answer: @entity2


abstract: @entity1 is a major public health problem due to its prevalence in practically all age groups. This is a study of the overall burden of @entity3 , @entity4 . The Disability-Adjusted Life Year (DALY) indicator was used as it simultaneously measures the impact of mortality and of health problems that affect the quality of life. The overall burden of @entity1 was analyzed in absolute terms and in rates per 1000 inhabitants. The number of @entity2 ( @entity2 ) due to @entity3 was 4,489. An estimated 33,888 @entity2 were lost due to edentulism, with a rate of 1.8/1000 (2.2/1000 among @entity0 ). An estimated 3217 @entity2 were lost due to @entity4 , with a rate of 0.2/1000 for both sexes. Edentulism was the condition that contributed most to the overall burden of @entity1 and is more frequent among @entity0 . Higher rates of @entity4 were found in @entity0 aged 45-69 years, while @entity3 was more frequent from 15-49 years. The overall burden of @entity1 studies represent an important aspect of health diagnosis, integrating both fatal and non-fatal outcomes. Furthermore, these studies provide highly relevant information for preventive and therapeutic policy making.

title: [A study of the overall burden of XXXX in the state of Minas Gerais, Brazil: 2004-2006].

answer: @entity1


abstract: Abstract Background: The added value of biomarkers, such as @entity4 (PCT), @entity3 ( @entity3 ), and white blood cells (WBC), as adjuncts to clinical risk scores for predicting the outcome of @entity0 with @entity2 ( @entity2 ) is in question. We investigated the prognostic accuracy of initial and follow-up levels of inflammatory biomarkers in predicting @entity1 and adverse clinical outcomes in a large and well-defined cohort of @entity2 @entity0 . Methods: We measured PCT, @entity3 and WBC on days 1, 3, 5, and 7 and followed the @entity0 over 30 days. We applied multivariate regression models and area under the curve (AUC) to investigate associations between these biomarkers, the clinical risk score CURB-65, and clinical outcomes [i.e., @entity1 and intensive care unit (ICU) admission]. Results: Of 925 @entity0 with @entity2 , 50 @entity0 died and 118 @entity0 had an adverse clinical outcome. None of the initial biomarker levels significantly improved the CURB-65 score for mortality prediction. Follow-up biomarker levels showed significant independent association with mortality at days 3, 5, and 7 and with improvements in AUC. Initial PCT and @entity3 levels were independent prognostic predictors of adverse clinical outcome, and levels of all biomarkers during the course of disease provided additional prognostic information. Conclusions: This study provides robust insights into the added prognostic value of inflammatory markers in @entity2 . @entity4 , @entity3 , and to a lesser degree WBC provided some prognostic information on @entity2 outcomes, particularly when considering their kinetics at days 5 and 7 and when looking at adverse clinical outcomes instead of mortality alone.

title: Utility of @entity4 , @entity3 and white blood cells alone and in combination for the prediction of clinical outcomes in XXXX .

answer: @entity2


abstract: Abstract Background: The added value of biomarkers, such as @entity4 (PCT), @entity3 ( @entity3 ), and white blood cells (WBC), as adjuncts to clinical risk scores for predicting the outcome of @entity0 with @entity2 ( @entity2 ) is in question. We investigated the prognostic accuracy of initial and follow-up levels of inflammatory biomarkers in predicting @entity1 and adverse clinical outcomes in a large and well-defined cohort of @entity2 @entity0 . Methods: We measured PCT, @entity3 and WBC on days 1, 3, 5, and 7 and followed the @entity0 over 30 days. We applied multivariate regression models and area under the curve (AUC) to investigate associations between these biomarkers, the clinical risk score CURB-65, and clinical outcomes [i.e., @entity1 and intensive care unit (ICU) admission]. Results: Of 925 @entity0 with @entity2 , 50 @entity0 died and 118 @entity0 had an adverse clinical outcome. None of the initial biomarker levels significantly improved the CURB-65 score for mortality prediction. Follow-up biomarker levels showed significant independent association with mortality at days 3, 5, and 7 and with improvements in AUC. Initial PCT and @entity3 levels were independent prognostic predictors of adverse clinical outcome, and levels of all biomarkers during the course of disease provided additional prognostic information. Conclusions: This study provides robust insights into the added prognostic value of inflammatory markers in @entity2 . @entity4 , @entity3 , and to a lesser degree WBC provided some prognostic information on @entity2 outcomes, particularly when considering their kinetics at days 5 and 7 and when looking at adverse clinical outcomes instead of mortality alone.

title: Utility of XXXX , @entity3 and white blood cells alone and in combination for the prediction of clinical outcomes in @entity2 .

answer: @entity4


abstract: Abstract Background: The added value of biomarkers, such as @entity4 (PCT), @entity3 ( @entity3 ), and white blood cells (WBC), as adjuncts to clinical risk scores for predicting the outcome of @entity0 with @entity2 ( @entity2 ) is in question. We investigated the prognostic accuracy of initial and follow-up levels of inflammatory biomarkers in predicting @entity1 and adverse clinical outcomes in a large and well-defined cohort of @entity2 @entity0 . Methods: We measured PCT, @entity3 and WBC on days 1, 3, 5, and 7 and followed the @entity0 over 30 days. We applied multivariate regression models and area under the curve (AUC) to investigate associations between these biomarkers, the clinical risk score CURB-65, and clinical outcomes [i.e., @entity1 and intensive care unit (ICU) admission]. Results: Of 925 @entity0 with @entity2 , 50 @entity0 died and 118 @entity0 had an adverse clinical outcome. None of the initial biomarker levels significantly improved the CURB-65 score for mortality prediction. Follow-up biomarker levels showed significant independent association with mortality at days 3, 5, and 7 and with improvements in AUC. Initial PCT and @entity3 levels were independent prognostic predictors of adverse clinical outcome, and levels of all biomarkers during the course of disease provided additional prognostic information. Conclusions: This study provides robust insights into the added prognostic value of inflammatory markers in @entity2 . @entity4 , @entity3 , and to a lesser degree WBC provided some prognostic information on @entity2 outcomes, particularly when considering their kinetics at days 5 and 7 and when looking at adverse clinical outcomes instead of mortality alone.

title: Utility of @entity4 , XXXX and white blood cells alone and in combination for the prediction of clinical outcomes in @entity2 .

answer: @entity3


abstract: BACKGROUND: Five-Year survival after pelvic exenteration for gynecologic @entity1 has been reported as high as 60%. The objective of this study was to determine @entity3 ( @entity3 ) after pelvic exenteration and evaluate factors impacting outcome. METHODS: A retrospective review of all @entity0 who underwent pelvic exenteration at our institution between February 1993 and December 2010 was performed. @entity3 was defined as time from exenteration to date of @entity2 or last contact. Survival analysis was performed using the Kaplan Meyer method. Multivariate analysis was performed to determine the impact of clinical and pathologic factors on survival outcomes. RESULTS: One hundred sixty @entity0 with gynecologic @entity1 underwent pelvic exenteration. Five-year @entity3 ( @entity3 ) was 33% (95%CI 0.25-0.40). Factors which negatively impacted @entity3 included shorter treatment-free interval (p=.050), vulvar primary (p=.032), positive margins (p<.001), lymphovascular space invasion (LVSI, p<.001), positive lymph nodes (p<.001) and perineural invasion (p=0.030). In multivariate analysis, positive margins (p=.040), positive nodes (p<.001) and lymphovascular space invasion (LVSI, p=.003) retained a significant impact on @entity3 . Five-year @entity3 was 40% (95% CI 0.32-0.48). Factors which negatively impacted @entity3 included vulvar primary (p=.04), positive margins (p<.001), LVSI (p<.001), positive lymph nodes (p<.001) and perineural invasion (p=.008). In multivariate analysis, positive nodes (p=.001) and LVSI (p=.001) retained a significant impact on @entity3 . CONCLUSION: Five-year @entity3 after pelvic exenteration was 40%. Survival outcomes have not significantly improved despite improvements in technique and @entity0 selection. Multiple non-modifiable factors at the time of exenteration are associated with poor survival.

title: Overall survival after pelvic exenteration for gynecologic XXXX .

answer: @entity1


abstract: OBJECTIVE: The real benefit of follow-up cervical cytology in @entity0 treated for gynecological @entity1 is unclear. This study was designed to assess the rate of success of cytological examinations in the detection of early vaginal recurrence of gynecological @entity1 in @entity0 found by other methods to have vaginal recurrence of cervical and @entity3 . DATA SOURCES: Records of cytological examinations. STUDY SELECTION: Thirty-three @entity0 treated for early and invasive cervical and @entity3 with recurrence in the vaginal vault were retrospectively analyzed. DATA EXTRACTION: Records from 1979 to 2010. DATA SYNTHESIS: Sixteen @entity0 (48.5%) had symptomatic vaginal recurrence associated with distant metastases, whereas 17 (51.5%) had vaginal recurrence only. Cytology was negative in 12 @entity0 (36.4%) with both symptomatic and asymptomatic recurrence and positive in the other 21 (63.6%). In 9 of these 21 @entity0 (42.9%), the disease was limited to the vaginal vault, whereas the remaining 12 (57.1%) presented with @entity2 associated with distant metastases. Cytology was positive in 9 of the 17 (52.9%) @entity0 whose recurrence was limited to the vaginal vault and negative in 8 (47.1%). CONCLUSION: Vaginal cytology yielded false-negative results in almost half of the @entity0 with vaginal recurrence of gynecological @entity1 . Patents of methods used for early diagnosis and detection of immortalization of cervical @entity1 are also reviewed in this article.

title: Cytology for the detection of early recurrence of XXXX in the vaginal vault.

answer: @entity1


abstract: BACKGROUND: Targeted therapy has improved the survival of @entity0 with metastatic @entity2 . In the present study, we evaluated whether there was an effect of cytoreductive surgery on prognosis of @entity0 with metastatic @entity2 using antiangiogenic @entity1 kinase inhibitor (TKI) agents. @entity0 AND METHODS: A total of 52 @entity0 with metastatic @entity2 from Akdeniz University, Afyon Kocatepe University, and Medipol University participated in the study. All the @entity0 had received targeted antiangiogenic therapy after interferon alfa-2b. According to previous @entity3 , the @entity0 were divided into 2 groups as @entity3 (+) and @entity3 (-). RESULTS: The @entity3 (+) group was younger than the @entity3 (-) group (P  < .001) and the hemoglobin levels were significantly higher in the @entity3 (+) group (P  = .023). The median progression-free survival time from the date of starting TKIs were 8.5 and 3.0 months for the @entity3 (+) and @entity3 (-) groups, respectively (P  = .104). The median overall survival was 15.1 and 5.4 months for the @entity3 (+) and @entity3 (-) groups, respectively (P  = .034). CONCLUSION: We speculate that @entity3 is still an important part of treatment modalities in @entity0 with metastatic @entity2 in modern era targeted therapy, which is currently the best systemic therapy. However, the indications of @entity3 might be limited to good-risk @entity0 with metastatic @entity2 . Further randomized studies are warranted to clarify the necessity of @entity3 in @entity0 with metastatic @entity2 .

title: The Necessity of Cytoreductive Nephrectomy in @entity0 With XXXX Using Antiangiogenic Targeted Therapy After Interferon Alfa-2b.

answer: @entity2


abstract: BACKGROUND: Targeted therapy has improved the survival of @entity0 with metastatic @entity2 . In the present study, we evaluated whether there was an effect of cytoreductive surgery on prognosis of @entity0 with metastatic @entity2 using antiangiogenic @entity1 kinase inhibitor (TKI) agents. @entity0 AND METHODS: A total of 52 @entity0 with metastatic @entity2 from Akdeniz University, Afyon Kocatepe University, and Medipol University participated in the study. All the @entity0 had received targeted antiangiogenic therapy after interferon alfa-2b. According to previous @entity3 , the @entity0 were divided into 2 groups as @entity3 (+) and @entity3 (-). RESULTS: The @entity3 (+) group was younger than the @entity3 (-) group (P  < .001) and the hemoglobin levels were significantly higher in the @entity3 (+) group (P  = .023). The median progression-free survival time from the date of starting TKIs were 8.5 and 3.0 months for the @entity3 (+) and @entity3 (-) groups, respectively (P  = .104). The median overall survival was 15.1 and 5.4 months for the @entity3 (+) and @entity3 (-) groups, respectively (P  = .034). CONCLUSION: We speculate that @entity3 is still an important part of treatment modalities in @entity0 with metastatic @entity2 in modern era targeted therapy, which is currently the best systemic therapy. However, the indications of @entity3 might be limited to good-risk @entity0 with metastatic @entity2 . Further randomized studies are warranted to clarify the necessity of @entity3 in @entity0 with metastatic @entity2 .

title: The Necessity of Cytoreductive Nephrectomy in XXXX With @entity2 Using Antiangiogenic Targeted Therapy After Interferon Alfa-2b.

answer: @entity0


abstract: Background. @entity3 is a highly prevalent, poorly managed, and disabling consequence of @entity1 ( @entity1 ). Exercise training that improves physical fitness represents a promising approach for managing @entity3 in @entity0 with @entity1 . There is limited evidence that physical fitness is associated with multiple domains of @entity3 across levels of @entity4 . Objective. This cross-sectional study examined the associations among aerobic capacity, lower limb muscle strength, and cognitive functions in @entity0 with mild, moderate, and severe @entity4 . Methods. The sample included 62 @entity0 with mild (n = 20), moderate (n = 21), and severe (n = 21) @entity4 . The @entity0 underwent neuropsychological assessments of cognitive processing speed (CPS; Symbol Digit Modalities Test [SDMT]), verbal memory (California Verbal Learning Test-2 [CVLT-2]), and visual memory (Brief Visuospatial Memory Test-Revised [BVMT-R]). All @entity0 further underwent testing for measuring aerobic capacity (ie, peak @entity2 consumption) and muscular strength (ie, peak torque of knee flexors and extensors). Results. Aerobic capacity and muscular strength outcomes were associated with SDMT (r = .35-.41), but not CVLT-2 or BVMT-R (r < .19) scores in the overall sample. Aerobic capacity (r = .42) and knee flexor peak torque (r = .39) were associated with SDMT scores in @entity0 with mild disability, but not in those with moderate (r < .06) and severe (r < .14) disability. Conclusions. These results support examining aerobic and resistance exercise training programs for improving CPS, particularly among @entity0 with mild @entity4 .

title: Association Between Physical Fitness and Cognitive Function in XXXX : Does Disability Status Matter?

answer: @entity1


abstract: PURPOSE: To locate the muscarinic (M) M2 and M3 receptors in bladder interstitial cells of Cajal (ICCs) and to determine the effects of M2 and M3 agonists on bladder ICCs. MATERIALS AND METHODS: A total of 30 adult male @entity0 weighing 225-250 g were used in this study. Double-labeled fluorescence of muscarinic receptors and c-kit was performed for co-localization. To evaluate the effect of muscarinic agents on the excitation of bladder ICCs, we analyzed the inward current of bladder ICCs using the whole-cell patch clamp. The effect of muscarinic agents on the @entity4 -induced inward currents was evaluated with the whole-cell patch clamp. RESULTS: M2 and M3 receptors were confirmed in the stroma ICCs in @entity0 ' bladders with double-labeled immunofluorescence. Spontaneous action potential was observed in freshly isolated bladder ICCs. The @entity4 -induced inward @entity1 current in ICCs can be blocked by @entity2 . The M2 receptor antagonist @entity5 (1  M) showed a weak inhibitory capability on the inward @entity1 current [from 74.8    9.6 to 63.3    13.8 Pascal (pA), n = 12, P = .03]. While the M3 receptor antagonist @entity3 ( @entity3 ) (1  M) significantly inhibited the inward @entity1 current (from 78.4    11.2 to 17.3    7.9 pA, n = 12, P < .001). CONCLUSION: Bladder ICCs express M2 and M3 cholinergic receptors. Most muscarinic cholinergic receptor antagonists, especially the M3 antagonists, can effectively inhibit the @entity4 - induced inward current of bladder ICCs.

title: Expression and function of muscarinic subtype receptors in bladder interstitial cells of cajal in XXXX .

answer: @entity0


abstract: Background. Several pilot studies have evoked interest in robot-assisted therapy ( @entity1 ) in @entity0 with @entity2 ( @entity2 ). Objective. To assess the effectiveness of @entity1 in @entity0 with @entity2 through a single-blind randomized controlled trial. @entity0 and Methods. Sixteen @entity0 with @entity2 were randomized into 2 groups. Eight @entity0 performed 5 conventional therapy sessions per week over 8 weeks (control group). Eight @entity0 completed 3 conventional therapy sessions and 2 robot-assisted sessions per week over 8 weeks (robotic group). For both groups, each therapy session lasted 45 minutes. Throughout each @entity1 session, the @entity0 attempted to reach several targets consecutively with the REAPlan. The REAPlan is a distal effector robot that allows for displacements of the upper limb in the horizontal plane. A blinded assessment was performed before and after the intervention with respect to the International Classification of Functioning framework: body structure and function (upper limb kinematics, Box and Block test, Quality of Upper Extremity Skills Test, strength, and @entity3 ), activities (Abilhand-Kids, Pediatric Evaluation of Disability Inventory), and participation (Life Habits). Results. During each @entity1 session, @entity0 performed 744 movements on average with the REAPlan. Among the variables assessed, the smoothness of movement (P < .01) and manual dexterity assessed by the Box and Block test (P = .04) improved significantly more in the robotic group than in the control group. Conclusions. This single-blind randomized controlled trial provides the first evidence that @entity1 is effective in @entity0 with @entity2 . Future studies should investigate the long-term effects of this therapy.

title: Upper Limb Robot-Assisted Therapy in XXXX : A Single-Blind Randomized Controlled Trial.

answer: @entity2


abstract: UNASSIGNED: Observational studies on long-term outcomes following debulking surgery or surgical biopsy for unresectable @entity2 showed various results. This meta-analysis was designed to determine the effect of debulking surgery against surgical biopsy on overall survival in @entity0 with unresectable @entity2 . The PubMed database was queried for studies published in the English language on unresectable @entity2 and overall survival. We compared overall survival following surgery in @entity0 undergoing debulking surgery and @entity0 undergoing surgical biopsy for unresectable @entity2 . Meta-analysis was performed using the Mantel-Haenszel method, and potential publication bias was evaluated with a funnel plot of precision. No randomized trials on this topic were identified. Thirteen retrospective observational studies containing a sum of 314 @entity0 with information on the number of @entity1 and @entity0 -years were suitable for analysis. Information on Masaoka stages, World Health Organization histology and indications for debulking surgery versus surgical biopsy was lacking in most studies. Diversity of neoadjuvant and adjuvant treatments was noted among the eligible studies. One hundred and seventy-two (54.8%) @entity0 underwent debulking surgery and 142 (45.2%) underwent surgical biopsy. The pooled hazard ratio was 0.451 (95% confidence interval: 0.336-0.605, P < 0.001), favouring @entity0 undergoing debulking surgery compared with @entity0 undergoing surgical biopsy. The funnel plot of precision demonstrated no important publication bias. Our results suggest that debulking surgery for unresectable @entity2 may be associated with improved overall survival and be considered for @entity0 with unresectable @entity2 .

title: A meta-analysis of debulking surgery versus surgical biopsy for unresectable XXXX   .

answer: @entity2


abstract: AIM: To investigate recurrence rates, patterns and complications after nonoperatively managed @entity2 ( @entity2 ). METHODS: A retrospective study of @entity0 treated for @entity2 was performed. @entity2 was defined on computed tomography by the presence of a localized abscess, pelvic abscess or extraluminal air. For follow-up, @entity0 were contacted by telephone. Numbers of elective surgeries, recurrences and @entity1 were analyzed. RESULTS: A total of 114 @entity0 (median age 57 years (range 29-97)), were admitted for @entity2 . Nine @entity0 required surgical intervention for failure of conservative therapy (Hartmann's procedure: n = 6; resection and colorectal anastomosis: n = 3). Of the 105 remaining @entity0 , 24 (22.9%) underwent elective sigmoid resection. The 81 (71%) non-operated @entity0 were all contacted after a median follow-up of 32 mo (4-63). Among them, six had developed a recurrent episode of @entity3 at a median follow-up of 12 mo (6-36); however, no @entity0 required hospitalization. Sixty-eight @entity0 (84%) were asymptomatic and 13 (16%) had recurrent @entity1 . CONCLUSION: Conservative policy is feasible and safe in 71% of cases, with a low medium-term recurrence risk.

title: Elective operation after acute XXXX : is it still mandatory?

answer: @entity2


abstract: In this study, the effects of surgical removal of @entity3 with epiphysis preservation and knee arthroplasty were analyzed. A total of 15 @entity0 with @entity3 were investigated. Six of these @entity0 underwent epiphyseal preservation surgery with preoperative physeal distraction, termed the physeal distraction (PD) group. Nine @entity0 underwent resection of the knee joint, combined with metal prosthesis transfer, termed the knee arthroplasty (KA) group. Tumor control, limb length discrepancy, range of movement (ROM) of the knee and functional outcome of lower limb [Musculoskeletal Tumor Society (MSTS) score and the Toronto extremity salvage score (TESS)] were assessed for these two groups. All 15 @entity0 were followed-up after the surgery. One @entity0 in the PD group was found to have @entity1 metastasis; however, no local @entity2 recurrence was found. In the KA group, local @entity2 recurrence was found in one @entity0 , and lung metastases were observed in two cases postoperatively. The limb length discrepancy in @entity0 of the PD group was 2.58  0.27 cm, which was significantly less compared with that in @entity0 in the KA group (4.01  0.13 cm; P<0.05). In addition, the lower limb knee ROM in @entity0 in the PD group was 127.70  14.63  , which was increased compared to that in @entity0 in the KA group (105.70  15.48  ; P<0.05). The mean MSTS score was 86.67% with a mean TESS of 82.33% in @entity0 from the PD group, which showed no significant difference compared with the respective scores for @entity0 in the KA group (P>0.05). Therefore, epiphyseal sparing limb-saving surgeries should be considered for the treatment of @entity3 in @entity0 , when certain indications are satisfied.

title: Effects of metaphyseal XXXX removal with preservation of the epiphysis and knee arthroplasty.

answer: @entity3