abstract: STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the incidence of @entity2 after anterior screw fixation of type II and rostral shallow @entity1 and to identify related risk factors. SUMMARY OF BACKGROUND DATA: Although several studies have reported fusion rates after anterior odontoid screw fixation of type II and rostral shallow @entity1 , few reports have analyzed in detail the risk factors associated with @entity2 . METHODS: Forty-one @entity0 with a type II and rostral shallow type III odontoid @entity1 were treated using anterior screw fixation. The @entity0 were 33 @entity0 and 8 @entity0 mean age = 46.6 years; age range = 15-79 years. Range of follow-up was 7 to 48 months. RESULTS: Anterior odontoid screw fixation resulted in solid bony union in 33 @entity0 (80.5%), fibrous union in 3 (7.3%), and nonunion in 5 (12.2%). When surgery was delayed for more than 1 week, the incidence of @entity2 significantly increased (P = 0.0051). Furthermore, a @entity1 gap of 2 mm or more was found to be significantly associated with @entity2 (P = 0.0172). However, @entity0 age and @entity1 were not found to be significantly associated with @entity2 (P = 0.8236 and P = 0.5762, respectively). CONCLUSION: Our study of anterior odontoid screw fixation reveals that the risk of @entity2 is 37.5 times greater in @entity0 with a delay of more than 1 week before operation, and 21 times greater in @entity0 with a @entity1 gap of greater than 2 mm.

title: Analysis of risk factors associated with XXXX after anterior odontoid screw fixation.

answer: @entity2


abstract: Fundamental and clinical studies were carried out on @entity9 suppository (CZX-S), and the following results were obtained in pediatrics. In 4 @entity0 of the CZX-S 125 mg-administered group (9.4-9.9 mg/kg), the serum concentration of CZX reached a peak of 5.55 micrograms/ml on the average, 30 minutes after dosing, i.e. at the time of initial blood collection, and decreased gradually to 0.20 microgram/ml 6 hours after dosing. The half-life was 1.09 hours. In 5 @entity0 of the CZX-S 250 mg-administered group (8.4-18.1 mg/kg), the serum concentration of CZX peaked at 7.07 micrograms/ml on the average and then gradually declined to 0.16 microgram/ml 6 hours after dosing. The half-life was 1.00 hour. The urinary recovery rate varied as widely as 6.5-38.0% in all the @entity0 of both groups. CZX-S was given to total 19 @entity0 ; 8 @entity0 with @entity3 ( @entity3 ), 3 with @entity8 or @entity7 , 4 with @entity6 , 2 with @entity1 , 1 with @entity5 media and 1 with staphylococcal scalding @entity2 . The overall effect of CZX-S in 15 @entity0 was "effective" or better response, with an effectiveness rate of 83.3%, except one who discontinued the drug because of side effects. CZX-S was given to most of the @entity0 weighing 15 kg or higher in a dose of 250 mg 3-4 times a day and frequently to @entity0 weighing less than 15 kg in a dose of 125 mg 3-4 times a day. As to side effects, slight @entity4 was encountered in 1 @entity0 . Laboratory examinations disclosed an increase in GOT in 1 @entity0 , which returned to normal after continual insertion of the suppository.

title: [Fundamental and clinical studies of XXXX suppositories in pediatrics].

answer: @entity9


abstract: A retrospective analysis of 3052 gastroscopies made by our Digestive Endoscopy Department from 1974 to 1979 was carried out. 14 Early @entity2 out of a total of 157 @entity2 were diagnosed (8.9%), with an EGC: Gastroscopies ratio = 1:218. From the macroscopic point of view 8 were found to belong to type III, 5 to type II, and 1 to type I. The main location was the lesser curvature (angulus-antrum). With regard to the degree of infiltration, 2 were found to belong to stage 0a, 8 to stage 0b, and 5 to stage I. The endoscopic observation gave reason to suspect the presence of a @entity1 in 6 of the 14 cases. The bioptic examination proved positive in 10 cases, while in 4 the diagnosis was made on the operatory piece. The importance of multiple bioptic samples is again confirmed. Cytology performed by brushing showed malignant tumoral cells in 4 cases, and again in 4 cases the radiological examination led to suspicion of @entity3 . 13 @entity0 were subjected to surgery during which no metastases to the locoregional lymphonodes were found; the @entity0 are all alive. We started @entity2 screening by selecting the @entity0 on the basis of a worksheet covering epidemiological, clinical, biohumoural and instrumental parameters, since the prognosis for the disease is directly proportional to the earliness of its diagnosis.

title: [Early XXXX : a retrospective study of our cases (1974-1979)].

answer: @entity2


abstract: Glucocorticoid receptors were quantitated by a whole cell method in cells from 593 @entity0 with @entity4 at the time of diagnosis. @entity3 cells were also immunologically typed and divided into early pre-B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-negative, cytoplasmic immunoglobulin-negative), pre-B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-negative, cytoplasmic immunoglobulin-positive), B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-positive), and T- (reactive with antibodies to T-lymphocyte antigens) subtypes. There was a median of 9.7 X 10(3) sites per cell in the 359 with early pre-B- @entity1 , a median of 8.1 X 10(3) sites per cell from 103 @entity0 with @entity5 , and a median of 4.0 X 10(3) sites per cell from 116 @entity0 with @entity2 . The distributions per cell were significantly different among these 3 groups (P less than 0.0001). The 15 @entity0 with B-cell disease had a median of 3.2 X 10(3) sites per cell. At the time of analysis, remission induction data are available for most of these @entity0 . Within the early pre-B- group 291 @entity0 with a median receptor number of 9.9 X 10(3) achieved remission, while 13 with a median receptor number of 4.8 X 10(3) did not. These distributions were significantly different (P = 0.034). Within the pre-B- and T-cell groups the distributions of receptor numbers for responders and non-responders were not significantly different. We conclude that each immunological subtype has characteristic receptor distribution. High receptor number within the null group is associated with the ability of the @entity0 to achieve remission; however, the range of values within each @entity0 group is too broad to use this assay as a predictor of response for any individual @entity0 .

title: Glucocorticoid receptors in immunological subtypes of childhood XXXX cells: a Pediatric Oncology Group Study.

answer: @entity1


abstract: Forty-five @entity0 and fifteen @entity0 with @entity7 have been treated surgically. @entity0 with @entity1 received pituitary irradiation and postoperative @entity10 was treated with @entity8 . The @entity0 have been followed-up for 6-36 months following the operation. The @entity1 were larger and the levels of production higher in @entity0 as compared with @entity0 . All @entity0 had @entity12 . @entity13 was present in forty-three @entity0 but not in the @entity0 . After surgery serum @entity11 levels fell significantly in all @entity0 but remained above normal in thirty-six; @entity11 remained high in twelve @entity0 . @entity8 effectively decreased the postoperative @entity10 . The surgical complications were @entity9 in one @entity0 and one @entity0 . After surgery six (23%) @entity0 developed @entity2 , six (15%) @entity6 , eight (18%) impaired @entity5 secretion and five (17%) impaired LH secretion in isolation or combination which had not been present preoperatively. Three @entity0 relapsed. Fifteen @entity0 menstruated after surgery and ten began to do so during the subsequent @entity8 treatment. Thus, menstruation was restored in all six @entity0 with microadenomas in sixteen of twenty @entity0 with intrasellar macroadenomas and three of nineteen @entity0 with suprasellar @entity4 . The preoperative LH-reserve proved to be an important prognostic indicator. Nine @entity0 , i.e. 50% of @entity0 desiring fertility became pregnant. In the @entity0 gonadal function deteriorated in four @entity0 and did not improve in any without @entity3 treatment.

title: Pituitary function in @entity7 . Effect of surgery and postoperative XXXX therapy.

answer: @entity8


abstract: Forty-five @entity0 and fifteen @entity0 with @entity7 have been treated surgically. @entity0 with @entity1 received pituitary irradiation and postoperative @entity10 was treated with @entity8 . The @entity0 have been followed-up for 6-36 months following the operation. The @entity1 were larger and the levels of production higher in @entity0 as compared with @entity0 . All @entity0 had @entity12 . @entity13 was present in forty-three @entity0 but not in the @entity0 . After surgery serum @entity11 levels fell significantly in all @entity0 but remained above normal in thirty-six; @entity11 remained high in twelve @entity0 . @entity8 effectively decreased the postoperative @entity10 . The surgical complications were @entity9 in one @entity0 and one @entity0 . After surgery six (23%) @entity0 developed @entity2 , six (15%) @entity6 , eight (18%) impaired @entity5 secretion and five (17%) impaired LH secretion in isolation or combination which had not been present preoperatively. Three @entity0 relapsed. Fifteen @entity0 menstruated after surgery and ten began to do so during the subsequent @entity8 treatment. Thus, menstruation was restored in all six @entity0 with microadenomas in sixteen of twenty @entity0 with intrasellar macroadenomas and three of nineteen @entity0 with suprasellar @entity4 . The preoperative LH-reserve proved to be an important prognostic indicator. Nine @entity0 , i.e. 50% of @entity0 desiring fertility became pregnant. In the @entity0 gonadal function deteriorated in four @entity0 and did not improve in any without @entity3 treatment.

title: Pituitary function in XXXX . Effect of surgery and postoperative @entity8 therapy.

answer: @entity7


abstract: 1. Mucus samples obtained from colectomy colons from 10 @entity0 with @entity2 and four @entity0 with @entity1 of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated from mucosal scrapings by gel-permeation chromatography. The high-molecular-weight fraction consisted largely of mucus glycoproteins and was further purified to the glycopolypeptides. The low-molecular-weight fraction contained a glycoprotein with a high @entity5 content. The @entity3 content of both the mucus glycoprotein and glycopolypeptide fractions were significantly reduced in active @entity4 . 3. Oligosaccharides were prepared from the mucus glycoprotein material. In the normal material more than half the units contained eight or more @entity6 residues, whereas in the disease material the bulk of the units were smaller than this.

title: Study of the XXXX content of mucus glycoproteins from normal and diseased colons.

answer: @entity3


abstract: Peripheral plasma concentrations of @entity5 (PGFM), @entity1 , @entity3 and @entity4 were determined in 20 sows for two days before and three weeks after parturition. Groups of four sows each received one of the following five treatments post partum: 30 ml sterile 0.9 per cent saline solution intrauterinely; ovariectomy and 30 ml saline solution intrauterinely; 10 ml Lugol's @entity2 plus 20 ml saline solution intrauterinely; ovariectomy and 10 ml Lugol's @entity2 plus 20 ml saline solution intrauterinely, or @entity1 (0.5 mg [kg bodyweight]-1 intramuscularly). Saline solution and @entity2 were administered every 48 hours, @entity0 immediately after parturition, for one week. Ovariectomy was performed within eight hours of delivery. @entity1 was given every third day for 12 days. Piglet weight gains were used as a reflection of milk yield. In all sows, @entity4 values were elevated before parturition, but fell by the end of delivery and were very low during lactation. PGFM concentrations rose during the last two days of pregnancy to reach maximal values at the time of delivery. Plasma @entity1 levels declined concomitantly with the rise in PGFM values before parturition. Basal values of @entity1 were achieved within 24 hours after delivery in control sows receiving saline treatment. @entity1 values fell immediately after ovariectomy in sows receiving saline or @entity2 treatment but were slightly elevated for one week in sows that received only intrauterine @entity2 treatment, suggesting that complete regression of corpora lutea is prevented by suppression of post parturient uterine prostaglandin production. Sows injected with @entity1 maintained plasma values of about 5 to 15 nmol litre-1.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Prostaglandin F2 alpha and XXXX in experimental hypogalactia in sows.

answer: @entity3


abstract: Serum radioimmunoassayable @entity1 (T), @entity3 and luteinizing hormone (LH) were determined before and after @entity2 ( @entity5 ) administration in 35 @entity0 with @entity4 ( @entity4 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity5 conditions. @entity1 values obtained in 5 normal @entity0 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity5 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity0 with @entity4 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity5 , 1.67 +/- 1.49nmol/l. @entity0 with @entity4 were divided into 4 groups according to T results in the @entity5 test (mean +/- SD in both basal and post- @entity5 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity3 , was obtained. No LH modifications after @entity5 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity4 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum XXXX obtained in multiple blood samples from @entity0 with @entity4 in both basal and post- @entity2 conditions.

answer: @entity1


abstract: Serum radioimmunoassayable @entity1 (T), @entity3 and luteinizing hormone (LH) were determined before and after @entity2 ( @entity5 ) administration in 35 @entity0 with @entity4 ( @entity4 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity5 conditions. @entity1 values obtained in 5 normal @entity0 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity5 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity0 with @entity4 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity5 , 1.67 +/- 1.49nmol/l. @entity0 with @entity4 were divided into 4 groups according to T results in the @entity5 test (mean +/- SD in both basal and post- @entity5 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity3 , was obtained. No LH modifications after @entity5 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity4 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum @entity1 obtained in multiple blood samples from @entity0 with @entity4 in both basal and post- XXXX conditions.

answer: @entity2


abstract: Serum radioimmunoassayable @entity1 (T), @entity3 and luteinizing hormone (LH) were determined before and after @entity2 ( @entity5 ) administration in 35 @entity0 with @entity4 ( @entity4 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity5 conditions. @entity1 values obtained in 5 normal @entity0 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity5 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity0 with @entity4 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity5 , 1.67 +/- 1.49nmol/l. @entity0 with @entity4 were divided into 4 groups according to T results in the @entity5 test (mean +/- SD in both basal and post- @entity5 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity3 , was obtained. No LH modifications after @entity5 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity4 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum @entity1 obtained in multiple blood samples from @entity0 with XXXX in both basal and post- @entity2 conditions.

answer: @entity4


abstract: Serum radioimmunoassayable @entity1 (T), @entity3 and luteinizing hormone (LH) were determined before and after @entity2 ( @entity5 ) administration in 35 @entity0 with @entity4 ( @entity4 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity5 conditions. @entity1 values obtained in 5 normal @entity0 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity5 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity0 with @entity4 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity5 , 1.67 +/- 1.49nmol/l. @entity0 with @entity4 were divided into 4 groups according to T results in the @entity5 test (mean +/- SD in both basal and post- @entity5 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity3 , was obtained. No LH modifications after @entity5 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity4 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum @entity1 obtained in multiple blood samples from XXXX with @entity4 in both basal and post- @entity2 conditions.

answer: @entity0


abstract: OBJECTIVE: To evaluate the feasibility of tracking @entity3 ( @entity2 )-wrapped superparamagnetic @entity0 (SPIO) nanoparticle-labeled, bone marrow-derived mesenchymal stem cells (BMSCs) by in vivo magnetic resonance imaging (MRI) in articular cartilage repair in a minipig model. METHODS: Eighteen Guizhou minipigs were randomly divided into three groups (groups A, B, and C). In group A, @entity2 -wrapped SPIO nanoparticle ( @entity2 /SPIO) and green fluorescent protein (GFP) colabeled, autologous BMSCs seeded in type II collagen gel were transplanted into the articular cartilage defects of the minipig model. In group B, GFP-labeled, autologous BMSCs seeded in type II collagen gel were transplanted. In group C, no treatment was applied for cartilage defects. All minipigs underwent clinical 3.0-T MR imaging at 4, 8, 12, and 24 weeks postsurgery. The findings were compared histologically. RESULTS: Prussian staining and transmission electron microscope showed that BMSCs were efficiently labeled by @entity2 /SPIO. Cell viability, proliferation, and differentiation were comparable between labeled and unlabeled cells. MRI @entity4 WI sequence revealed that marked @entity1 representing the transplanted labeled BMSCs could be observed for at least 24 weeks. Histochemical staining confirmed the presence of Prussian blue-positive cells and GFP-positive cells at the @entity1 . At 24 weeks postsurgery, both MR signals and histologic staining of minipigs in groups A and B at the cartilage defect were close to the normal cartilage. CONCLUSIONS: 3.0-T MRI in vivo tracking of @entity2 /SPIO-labeled BMSCs seeded in type II collagen gel on cartilage repair following transplantation is feasible in minipigs.

title: In Vivo MRI Tracking of XXXX -Wrapped Superparamagnetic @entity0 Nanoparticle-Labeled BMSCs for Cartilage Repair: A Minipig Model.

answer: @entity3


abstract: OBJECTIVE: To evaluate the feasibility of tracking @entity3 ( @entity2 )-wrapped superparamagnetic @entity0 (SPIO) nanoparticle-labeled, bone marrow-derived mesenchymal stem cells (BMSCs) by in vivo magnetic resonance imaging (MRI) in articular cartilage repair in a minipig model. METHODS: Eighteen Guizhou minipigs were randomly divided into three groups (groups A, B, and C). In group A, @entity2 -wrapped SPIO nanoparticle ( @entity2 /SPIO) and green fluorescent protein (GFP) colabeled, autologous BMSCs seeded in type II collagen gel were transplanted into the articular cartilage defects of the minipig model. In group B, GFP-labeled, autologous BMSCs seeded in type II collagen gel were transplanted. In group C, no treatment was applied for cartilage defects. All minipigs underwent clinical 3.0-T MR imaging at 4, 8, 12, and 24 weeks postsurgery. The findings were compared histologically. RESULTS: Prussian staining and transmission electron microscope showed that BMSCs were efficiently labeled by @entity2 /SPIO. Cell viability, proliferation, and differentiation were comparable between labeled and unlabeled cells. MRI @entity4 WI sequence revealed that marked @entity1 representing the transplanted labeled BMSCs could be observed for at least 24 weeks. Histochemical staining confirmed the presence of Prussian blue-positive cells and GFP-positive cells at the @entity1 . At 24 weeks postsurgery, both MR signals and histologic staining of minipigs in groups A and B at the cartilage defect were close to the normal cartilage. CONCLUSIONS: 3.0-T MRI in vivo tracking of @entity2 /SPIO-labeled BMSCs seeded in type II collagen gel on cartilage repair following transplantation is feasible in minipigs.

title: In Vivo MRI Tracking of @entity3 -Wrapped Superparamagnetic XXXX Nanoparticle-Labeled BMSCs for Cartilage Repair: A Minipig Model.

answer: @entity0


abstract: OBJECTIVE: To predict, using clinical and qMRI data, the incidence of total knee replacement (TKR) during the long-term follow-up of @entity5 ( @entity4 ) @entity0 who formerly received chondroitin sulfate (CS) or placebo treatment. DESIGN: A post hoc intention-to-treat analysis to evaluate the incidence of TKR was done on knee @entity4 @entity0 who had participated in a 12-month trial evaluating the impact of CS (800 mg/d) versus placebo for 6 months, followed by a 6-month open-phase in which all @entity0 received CS. Additionally, the clinical and qMRI predictors of TKR were determined. RESULTS: Thirteen TKRs were performed in the population after a 4-year follow-up. More TKRs were performed in the placebo group than in the CS group (69% vs. 31%, P = 0.150, logistic regression). The statistically significant predictors of TKRs were, at baseline, higher WOMAC @entity1 and function scores, presence of @entity2 ( @entity2 ), and higher @entity6 levels. Loss of medial cartilage volume and increase in WOMAC @entity1 and function at one-year were also predictors of TKR. Multivariate analyses revealed that baseline presence of BML and higher WOMAC @entity1 score were independent predictors. Time to occurrence of the TKR also favored the CS group versus placebo (log-rank, P = 0.094). CONCLUSION: Symptoms such as knee @entity1 and function, presence of BML, and cartilage @entity3 predict the long-term occurrence of a "hard" outcome such as TKR.

title: Total Knee Replacement as a XXXX Outcome: Predictors Derived from a 4-Year Long-Term Observation following a Randomized Clinical Trial Using Chondroitin Sulfate.

answer: @entity5


abstract: BACKGROUND: Skeletal muscle depletion ( @entity4 ) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in @entity0 with unresectable @entity1 ( @entity1 ). METHODS: We conducted a retrospective analysis of 215 consecutive @entity0 with unresectable @entity1 who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy. RESULTS: One-hundred-eighty-two @entity0 met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or @entity3 ( @entity3 ) associated with skeletal muscle mass before chemotherapy. However, 22 @entity0 with skeletal @entity2 (>5%) after chemotherapy showed significantly shorter PFS and @entity3 compared with those without skeletal @entity2 (PFS, log-rank p = 0.029; @entity3 , log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal @entity2 after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with @entity3 . CONCLUSIONS: Skeletal @entity2 after chemotherapy was an independent, negative prognostic factor in unresectable @entity1 .

title: Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in @entity0 with Unresectable XXXX .

answer: @entity1


abstract: BACKGROUND: Skeletal muscle depletion ( @entity4 ) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in @entity0 with unresectable @entity1 ( @entity1 ). METHODS: We conducted a retrospective analysis of 215 consecutive @entity0 with unresectable @entity1 who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy. RESULTS: One-hundred-eighty-two @entity0 met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or @entity3 ( @entity3 ) associated with skeletal muscle mass before chemotherapy. However, 22 @entity0 with skeletal @entity2 (>5%) after chemotherapy showed significantly shorter PFS and @entity3 compared with those without skeletal @entity2 (PFS, log-rank p = 0.029; @entity3 , log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal @entity2 after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with @entity3 . CONCLUSIONS: Skeletal @entity2 after chemotherapy was an independent, negative prognostic factor in unresectable @entity1 .

title: Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in XXXX with Unresectable @entity1 .

answer: @entity0


abstract: OBJECTIVES: Since 1999, we have performed implantations of Remeex   adjustable prosthetics as rescue treatment for complex or persistent stress @entity1 (SUI) after failure of other surgical treatments (Burch colposuspension, Marshall-Marchetti-Krantz (MMK) or tension-free transvaginal tape [TVT] until 2003 and transobturator tape [TOT] since 2003). We present the results of our series, which include cases with severe complications. MATERIAL AND METHOD: Retrospective study of @entity0 diagnosed with complex or refractory SUI who underwent Remeex(  ) implantation between October 1999 and December 2013. In 5 cases, we conducted cystocele correction in the same operation as the placement of the Remeex(  ). RESULTS: Sixty @entity0 , with a mean age of 66.87 years (range 39-85), underwent operations. The procedure was successful in 68.33% of the cases. The failures consisted of the following: 10% of the @entity0 had mixed @entity1 ( @entity1 ) with @entity3 ; 8.33% had mild SUI; and 13.33% had urgency urination without @entity1 . Thirty-five percent required adjustments. We recorded 3 cases with severe complications: disabling severe @entity1 in a @entity0 who underwent multiple operations, massive @entity2 in a @entity0 undergoing standard antiplatelet therapy and infected vaginal calculi measuring 7cm on an extruding Remeex thread in a paraplegic @entity0 4 years after the implantation. CONCLUSIONS: Remeex(  ) is an effective and safe procedure for achieving continence in cases of complex or refractory SUI, although it is not exempt from severe complications. Following rigorous protocols can help detect complications and treat them in a timely manner.

title: Severe complications and failures of XXXX surgery using the Remeex(  ) adjustable tension sling (external mechanical regulator).

answer: @entity1


abstract: OBJECTIVES: In addition to exhibiting a severe contralesional deficit, @entity6 @entity0 may also show a @entity3 , called sightblindness (the reverse case of 'blindsight). We have tested for the presence, nature and extent of such an @entity3 in @entity6 @entity0 that we assigned to perform two visual tasks. Namely, we aimed to ascertain any links between this @entity1 , the lesion side, and the tasks performed or the stimuli used. METHODS: We tested left and right homonymous @entity6 (right brain-damaged RBD and left brain-damaged @entity7 , respectively) @entity0 and healthy controls. Natural-scene images, either non-filtered or filtered in low or high spatial frequency (LSF or @entity4 , respectively) were presented in the @entity3 of each subject. For the two tasks, detection ("Is an image present?") and categorization ("Is the image of a forest or a city?"), accuracy and response time were recorded. RESULTS: In the @entity3 the RBD (left hemianopes) @entity0 made more errors on the categorization task than did their matched controls, regardless of image type. In contrast, the only task in which the @entity7 ( @entity6 ) @entity0 made more errors than did the controls was the @entity4 -images task. Furthermore, in both tasks (detection and categorization), the RBD @entity0 performed worse than did the @entity7 @entity0 . DISCUSSION: @entity5 @entity0 do indeed exhibit a specific @entity3 in their @entity3 , which was previously thought to be unaffected. We have demonstrated that the nature and severity of this @entity1 is determined by the side of the @entity2 as well as by the tasks and the stimuli. Our findings corroborate the idea of hemispheric specialization at the occipital level, which might determine the nature and severity of @entity1 in @entity6 @entity0 .

title: Hemisphere-dependent @entity1 in XXXX : Sightblindness in the 'intact' visual field.

answer: @entity5


abstract: OBJECTIVES: In addition to exhibiting a severe contralesional deficit, @entity6 @entity0 may also show a @entity3 , called sightblindness (the reverse case of 'blindsight). We have tested for the presence, nature and extent of such an @entity3 in @entity6 @entity0 that we assigned to perform two visual tasks. Namely, we aimed to ascertain any links between this @entity1 , the lesion side, and the tasks performed or the stimuli used. METHODS: We tested left and right homonymous @entity6 (right brain-damaged RBD and left brain-damaged @entity7 , respectively) @entity0 and healthy controls. Natural-scene images, either non-filtered or filtered in low or high spatial frequency (LSF or @entity4 , respectively) were presented in the @entity3 of each subject. For the two tasks, detection ("Is an image present?") and categorization ("Is the image of a forest or a city?"), accuracy and response time were recorded. RESULTS: In the @entity3 the RBD (left hemianopes) @entity0 made more errors on the categorization task than did their matched controls, regardless of image type. In contrast, the only task in which the @entity7 ( @entity6 ) @entity0 made more errors than did the controls was the @entity4 -images task. Furthermore, in both tasks (detection and categorization), the RBD @entity0 performed worse than did the @entity7 @entity0 . DISCUSSION: @entity5 @entity0 do indeed exhibit a specific @entity3 in their @entity3 , which was previously thought to be unaffected. We have demonstrated that the nature and severity of this @entity1 is determined by the side of the @entity2 as well as by the tasks and the stimuli. Our findings corroborate the idea of hemispheric specialization at the occipital level, which might determine the nature and severity of @entity1 in @entity6 @entity0 .

title: Hemisphere-dependent XXXX in @entity5 : Sightblindness in the 'intact' visual field.

answer: @entity1


abstract: UNASSIGNED: Impairments in the mirror neuron system (MNS) have been implicated as a possible underlying neurological basis for @entity1 in @entity2 . Previous work testing this hypothesis has used the electroencephalographic mu rhythm as an index of MNS activity, with studies showing mixed results. Here we investigated the role that reward plays in modulating the mu rhythm, and its association with empathy and emotional mental state reasoning. A group of @entity2 @entity0 and a healthy control group completed an action observation paradigm in which they watched actions that were financially rewarding, punishing, or neutral. @entity0 showed intact reward-related modulation of the mu rhythm, and greater mu suppression was associated with greater negative symptoms. There was also a trend for reduced mu suppression in @entity0 . Furthermore, both empathy and emotional mental state reasoning were associated with the degree of mu suppression, but only in healthy controls. These findings confirm the association between the mu suppression and high-level social cognition. It is possible that @entity2 @entity0 @entity1 to infer mental states. The demonstration that reward influences the degree of mu suppression in @entity2 @entity0 may help to account for previous conflicting findings in the literature.

title: Reward modulates the mirror neuron system in XXXX : A study into the mu rhythm suppression, empathy, and mental state attribution.

answer: @entity2


abstract: BACKGROUND: Apolipoprotein (apo) distribution and lipoprotein (Lp)-associated markers of @entity0 , such as @entity11 ( @entity11 ), influence the atherogenicity of circulating lipids and lipoproteins. Little evidence exists regarding the dose-response effects of the marine @entity14 @entity12 ( @entity13 ) and @entity9 ( @entity10 ) on apos, apo-defined Lps, and @entity11 . OBJECTIVE: The purpose of this study was to compare the effects of 0, 0.85, and 3.4  g/d of @entity13  +  @entity10 on @entity11 mass and activity in individuals with moderate @entity7 . We also measured effects on concentrations of apoAI, @entity8 , @entity3 , apoC, @entity16 , and @entity6 -defined Lp subclasses. METHODS: The study was a randomized, doubleblind, crossover design with 8-week treatment periods and 6-week washout periods. During the 3 treatment periods, subjects (n  =  25) received 0  g/d @entity13  +  @entity10 , 0.85  g/d @entity13  +  @entity10 (low dose), and 3.4  g/d @entity13  +  @entity10 (high dose) in random order. RESULTS: @entity3 and @entity15 were significantly decreased by the high dose relative to placebo and low dose (P  <  .01), as was very low-density lipoprotein @entity1 (P  <  .005). The low dose had no effect on Lp outcomes compared with placebo. The high- and low-dose effects differed significantly for heparin-precipitated @entity15 , LpB, LpA-I, and @entity3 / @entity5 ratio (P  <  .05). There was a trend for a decreased @entity11 mass with the high dose (P  =  .1). CONCLUSION: The effects of 3.4  g/d @entity13  +  @entity10 on @entity3 and @entity15 may reduce @entity2 in individuals with elevated @entity4 .

title: Dose-response effects of marine XXXX on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and @entity11 in individuals with moderate @entity7 .

answer: @entity14


abstract: BACKGROUND: Apolipoprotein (apo) distribution and lipoprotein (Lp)-associated markers of @entity0 , such as @entity11 ( @entity11 ), influence the atherogenicity of circulating lipids and lipoproteins. Little evidence exists regarding the dose-response effects of the marine @entity14 @entity12 ( @entity13 ) and @entity9 ( @entity10 ) on apos, apo-defined Lps, and @entity11 . OBJECTIVE: The purpose of this study was to compare the effects of 0, 0.85, and 3.4  g/d of @entity13  +  @entity10 on @entity11 mass and activity in individuals with moderate @entity7 . We also measured effects on concentrations of apoAI, @entity8 , @entity3 , apoC, @entity16 , and @entity6 -defined Lp subclasses. METHODS: The study was a randomized, doubleblind, crossover design with 8-week treatment periods and 6-week washout periods. During the 3 treatment periods, subjects (n  =  25) received 0  g/d @entity13  +  @entity10 , 0.85  g/d @entity13  +  @entity10 (low dose), and 3.4  g/d @entity13  +  @entity10 (high dose) in random order. RESULTS: @entity3 and @entity15 were significantly decreased by the high dose relative to placebo and low dose (P  <  .01), as was very low-density lipoprotein @entity1 (P  <  .005). The low dose had no effect on Lp outcomes compared with placebo. The high- and low-dose effects differed significantly for heparin-precipitated @entity15 , LpB, LpA-I, and @entity3 / @entity5 ratio (P  <  .05). There was a trend for a decreased @entity11 mass with the high dose (P  =  .1). CONCLUSION: The effects of 3.4  g/d @entity13  +  @entity10 on @entity3 and @entity15 may reduce @entity2 in individuals with elevated @entity4 .

title: Dose-response effects of marine @entity14 on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and XXXX in individuals with moderate @entity7 .

answer: @entity11


abstract: BACKGROUND: Apolipoprotein (apo) distribution and lipoprotein (Lp)-associated markers of @entity0 , such as @entity11 ( @entity11 ), influence the atherogenicity of circulating lipids and lipoproteins. Little evidence exists regarding the dose-response effects of the marine @entity14 @entity12 ( @entity13 ) and @entity9 ( @entity10 ) on apos, apo-defined Lps, and @entity11 . OBJECTIVE: The purpose of this study was to compare the effects of 0, 0.85, and 3.4  g/d of @entity13  +  @entity10 on @entity11 mass and activity in individuals with moderate @entity7 . We also measured effects on concentrations of apoAI, @entity8 , @entity3 , apoC, @entity16 , and @entity6 -defined Lp subclasses. METHODS: The study was a randomized, doubleblind, crossover design with 8-week treatment periods and 6-week washout periods. During the 3 treatment periods, subjects (n  =  25) received 0  g/d @entity13  +  @entity10 , 0.85  g/d @entity13  +  @entity10 (low dose), and 3.4  g/d @entity13  +  @entity10 (high dose) in random order. RESULTS: @entity3 and @entity15 were significantly decreased by the high dose relative to placebo and low dose (P  <  .01), as was very low-density lipoprotein @entity1 (P  <  .005). The low dose had no effect on Lp outcomes compared with placebo. The high- and low-dose effects differed significantly for heparin-precipitated @entity15 , LpB, LpA-I, and @entity3 / @entity5 ratio (P  <  .05). There was a trend for a decreased @entity11 mass with the high dose (P  =  .1). CONCLUSION: The effects of 3.4  g/d @entity13  +  @entity10 on @entity3 and @entity15 may reduce @entity2 in individuals with elevated @entity4 .

title: Dose-response effects of marine @entity14 on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and @entity11 in individuals with moderate XXXX .

answer: @entity7


abstract: BACKGROUND: At a time of increasing high risk neonates, an assessment method is needed that can reliably predict @entity1 at an early age. AIMS: The objective of this study was to determine whether the assessment of @entity3 ( @entity3 ) will predict the neurological outcome of @entity0 with @entity5 ( @entity5 ). STUDY DESIGN: This study employed a prospective and descriptive plan. SUBJECTS: The study sample consisted of 15 @entity0 (8 male and 7 female) born at term. Video recording of @entity3 were analyzed at 3 to 5months' @entity0 , who identified with perinatal @entity4 and neonatal @entity5 . @entity3 were classified as present or absent. OUTCOME MEASURES: At 12-18months age, the @entity0 ' developmental outcome was classified as normal or abnormal according to the @entity0 Neurological International Battery test. "Abnormal outcome" was denoted as poor motor or neurological outcome such as @entity2 , whereas "Normal outcome" denotes normal motor and neurological outcomes. RESULTS: The predictive values of @entity3 were: a sensitivity 0.80 (95% CI: 0.44-0.96), a specificity 1.00 (95% CI: 0.47-1.00), and the accuracy 0.87 (0.57 to 1.00). CONCLUSIONS: @entity3 assessment improves our ability to predict later neurodevelopmental outcomes in term born @entity0 with neonatal @entity5 .

title: General movements as a predictive tool of the neurological outcome in term born @entity0 with XXXX .

answer: @entity5


abstract: BACKGROUND: At a time of increasing high risk neonates, an assessment method is needed that can reliably predict @entity1 at an early age. AIMS: The objective of this study was to determine whether the assessment of @entity3 ( @entity3 ) will predict the neurological outcome of @entity0 with @entity5 ( @entity5 ). STUDY DESIGN: This study employed a prospective and descriptive plan. SUBJECTS: The study sample consisted of 15 @entity0 (8 male and 7 female) born at term. Video recording of @entity3 were analyzed at 3 to 5months' @entity0 , who identified with perinatal @entity4 and neonatal @entity5 . @entity3 were classified as present or absent. OUTCOME MEASURES: At 12-18months age, the @entity0 ' developmental outcome was classified as normal or abnormal according to the @entity0 Neurological International Battery test. "Abnormal outcome" was denoted as poor motor or neurological outcome such as @entity2 , whereas "Normal outcome" denotes normal motor and neurological outcomes. RESULTS: The predictive values of @entity3 were: a sensitivity 0.80 (95% CI: 0.44-0.96), a specificity 1.00 (95% CI: 0.47-1.00), and the accuracy 0.87 (0.57 to 1.00). CONCLUSIONS: @entity3 assessment improves our ability to predict later neurodevelopmental outcomes in term born @entity0 with neonatal @entity5 .

title: General movements as a predictive tool of the neurological outcome in term born XXXX with @entity5 .

answer: @entity0


abstract: UNASSIGNED: This article reports a taxonomic classification of rare @entity4 based on metabolic phenotypes. It was prepared by The Skeletal Rare Diseases Working Group of the International @entity3 Foundation (IOF) and includes 116 OMIM phenotypes with 86 affected genes. INTRODUCTION: Rare skeletal metabolic diseases comprise a group of diseases commonly associated with severe clinical consequences. In recent years, the description of the clinical phenotypes and radiographic features of several genetic @entity2 was paralleled by the discovery of key molecular pathways involved in the regulation of bone and mineral metabolism. Including this information in the description and classification of rare @entity4 may improve the recognition and management of affected @entity0 . METHODS: IOF recognized this need and formed a Skeletal Rare Diseases Working Group (SRD-WG) of basic and clinical scientists who developed a taxonomy of rare @entity4 based on their metabolic pathogenesis. RESULTS: This taxonomy of @entity1 ( @entity1 ) comprises 116 OMIM phenotypes, with 86 affected genes related to bone and mineral homeostasis. The diseases were divided into four major groups, namely, disorders due to altered osteoclast, osteoblast, or osteocyte activity; disorders due to altered bone matrix proteins; disorders due to altered bone microenvironmental regulators; and disorders due to deranged calciotropic hormonal activity. CONCLUSIONS: This article provides the first comprehensive taxonomy of rare metabolic @entity4 based on deranged metabolic activity. This classification will help in the development of common and shared diagnostic and therapeutic pathways for these @entity0 and also in the creation of international registries of rare @entity4 , the first step for the development of genetic tests based on next generation sequencing and for performing large intervention trials to assess efficacy of orphan drugs.

title: Taxonomy of XXXX .

answer: @entity1


abstract: The association of @entity9 ( @entity9 ) with @entity11 is uncommon. The authors report on 9 pediatric cases (6 @entity0 and 3 @entity0 ). All the @entity0 (age 12 to 48 months) presented initially with a pure @entity9 . The syndrome was clinically severe and either initially or secondarily resistant to @entity3 and immunosuppressive therapy. In 6 cases initial renal biopsies showed @entity1 and in one case, segmental and focal hyalinization was observed. Symptoms of tubular insufficiency appeared progressively and included: proximal and distal @entity6 (9/9 cases), renal @entity12 (9/9 cases), @entity8 with hyperkaluria (7/9 cases), hypohposphatemia (4/9 cases), global hyperaminoaciduria (4/9 cases), tubular proteinura (2/9 cases). Control of water and electrolyte balance was difficult. The urinary concentration of @entity10 breakdown products was very high throughout the course of the disease. In all cases, @entity5 preceded the inevitable alteration of glomerular filtration which resulted in four cases of @entity4 after an average evolution of 2 to 3 years. Renal biopsies during the later stages of evolution demonstrated five cases of @entity1 with @entity2 associated in 3 cases with histiocytic infiltration. Immunologic studies were negative. The authors discuss the physiopathologic aspects of the disease including the possibility of @entity7 of intrarenal veins and compare their observations with those of Royer et al. [1963].

title: Severe idiopathic nephrotic syndrome with XXXX (report of nine pediatric cases).

answer: @entity11


abstract: PURPOSE: To determine whether the presence of intervertebral bridging ossifications is associated with intravertebral cleft (IVC) formation following a @entity2 ( @entity2 ). METHODS: @entity0 with a @entity2 who received conservative treatment for a minimum of 3  months were recruited over a 3-year period. Baseline radiographs obtained within a month of onset were compared between 50 @entity0 who developed an IVC at 3-month follow-up (IVC group) and 100 @entity0 without an IVC (control group). Intervertebral bridging ossification was defined as complete bridging of the intervertebral space by ossification. The presence of bridging ossification was assessed at each intervertebral level from T9/10 to L5/S. In addition to the absolute levels of bridging ossifications, the level relative to a fresh @entity2 was recorded. RESULT: The incidence of bridging ossification at levels T9/10 and @entity1 was significantly higher in the IVC group than in the control group. IVC group @entity0 showed a significantly higher incidence of bridging ossification at the second proximal intervertebral segment than those in the control group. IVC group @entity0 also had a significantly greater sagittal wedge angle and a greater local kyphosis angle than control group @entity0 . CONCLUSION: A fresh @entity2 with bridging ossification at the second proximal intervertebral level is associated with increased risk of IVC formation. Careful observation and strict conservative treatment are recommended in such cases.

title: Intervertebral bridging ossifications increase the risk of intravertebral cleft formation following a XXXX .

answer: @entity2


abstract: The changes in cell surface properties of Rahnella sp. strain @entity2 and modifications in genetic material after long-term contact with @entity1 and rhamnolipids, were investigated. Rhamnolipids caused a decrease of hydrophobicity in liquid cultures compared with @entity1 . On the other hand, in cultures with rhamnolipids, the addition of diesel oil results in a rapid rise of cell surface hydrophobicity. The similar effect was not so significant in the presence of @entity1 . For the bacteria grown in the presence of @entity1 or rhamnolipids, but without diesel oil, the ratio of unsaturated to @entity0 decreased, in comparison to the control culture. The differences observed in hydrophobicity, zeta potential and @entity0 profiles, indicated various mechanisms of an interaction between a surfactant and a bacterial cells. The results have also shown an impact of the long-term contact on changes in genetic material of Rahnella sp. strain @entity2 cells. Moreover, the presence of @entity1 led to significant increase of diesel oil biodegradation.

title: Rahnella sp. strain XXXX : Cell surface properties and diesel oil biodegradation after long-term contact with natural surfactants and diesel oil.

answer: @entity2


abstract: After the introduction of modern artificial joints the classical operation methods, such as osteotomies, arthrodeses and auto-arthroplasties, have been forced aside little by little. Irrespective of the late complications following replacement surgery, the @entity0 today expect a movable, painless endoprosthesis, which at it best seems to benefit the @entity0 . The question arises whether the classical methods still have a role in the surgical treatment of @entity1 . The reply is "yes", they do have a fair share of rheumatoid surgery, indeed. They still compete with the modern endoprosthetic surgery for the place of the primary operation in many cases. To give instances, tarsal reconstruction by subtaloid arthrodesis is superior to other methods and arthrodesis of the wrist is often only reasonable way to get a strong, painless key joint to the hand. Even the shoulder arthrodesis may successfully compete with an endoprosthesis. Also classical auto-arthroplasties such as resection arthroplasties of the metacarpophalangeal and @entity3 are serious rivals of respective endoprostheses. The practice of @entity2 Foundation Hospital (RFH) in the golden mean between the endoprosthesis enthusiasts and their opponents will be described in this article. The practice varies greatly from clinic to clinic and is progressing--and regressing--all the time.

title: The role of non-prosthetic surgery in the treatment of @entity1 by fusions and auto-arthroplasties. Current practice at the XXXX Foundation Hospital, Heinola.

answer: @entity2


abstract: After the introduction of modern artificial joints the classical operation methods, such as osteotomies, arthrodeses and auto-arthroplasties, have been forced aside little by little. Irrespective of the late complications following replacement surgery, the @entity0 today expect a movable, painless endoprosthesis, which at it best seems to benefit the @entity0 . The question arises whether the classical methods still have a role in the surgical treatment of @entity1 . The reply is "yes", they do have a fair share of rheumatoid surgery, indeed. They still compete with the modern endoprosthetic surgery for the place of the primary operation in many cases. To give instances, tarsal reconstruction by subtaloid arthrodesis is superior to other methods and arthrodesis of the wrist is often only reasonable way to get a strong, painless key joint to the hand. Even the shoulder arthrodesis may successfully compete with an endoprosthesis. Also classical auto-arthroplasties such as resection arthroplasties of the metacarpophalangeal and @entity3 are serious rivals of respective endoprostheses. The practice of @entity2 Foundation Hospital (RFH) in the golden mean between the endoprosthesis enthusiasts and their opponents will be described in this article. The practice varies greatly from clinic to clinic and is progressing--and regressing--all the time.

title: The role of non-prosthetic surgery in the treatment of XXXX by fusions and auto-arthroplasties. Current practice at the @entity2 Foundation Hospital, Heinola.

answer: @entity1


abstract: BACKGROUND: @entity2 (PHEO) is more frequently found in @entity0 with @entity3 2A carrying a @entity7 germline mutation located in codon 634 (C634). However, it is unclear whether different @entity4 substitutions within C634 cause differences in bilateral PHEOs expression. We aimed to answer this by pooling data from two Asian institutions. METHODS: Sixty-seven @entity0 had confirmed C634 germline mutation. Age-dependent penetrance of bilateral PHEO was calculated from date of birth to the date when bilateral PHEO was first diagnosed or when the contralateral gland became a PHEO (if the @entity0 already had one adrenal gland removed). Age-dependent penetrance was estimated by the Kaplan-Meier method and compared by log-rank test. RESULTS: The 4 different @entity4 substitutions included @entity9 ( @entity1 ) (n  =  19, 28.4  %), @entity10 ( @entity5 ) (n  =  36, 38.8  %), @entity11 ( @entity8 ) (n  =  4, 6.0  %), and C634W ( @entity6 ) (n  =  8, 11.9  %). The age-related penetrance of PHEO was similar between @entity9 , @entity10 , @entity11 , and C634W (by age 40, 69.8, 55.2, 25.0, and 56.2  %, respectively) (p  =  0.529). However, the age-related penetrance of bilateral PHEO in @entity9 was significantly higher than @entity10 (by age of 40, 59.3  % vs. 25.2  %, p  =  0.046) or @entity10 , @entity11 , and C634W combined (59.3  % vs. 21.5  %, p  =  0.024). Nevertheless, the accumulative risk of bilateral PHEOs across all four C634 mutations almost approached 100  % over time. CONCLUSION: The accumulative risk of bilateral PHEOs almost reached 100  % but its onset was significantly earlier in @entity9 mutation. These findings implied that those with @entity9 mutation might benefit from earlier screening of contralateral PHEO than other C634 mutations after an unilateral adrenalectomy.

title: @entity2 in XXXX Syndrome: A Two-Institution Experience.

answer: @entity7


abstract: BACKGROUND: @entity2 (PHEO) is more frequently found in @entity0 with @entity3 2A carrying a @entity7 germline mutation located in codon 634 (C634). However, it is unclear whether different @entity4 substitutions within C634 cause differences in bilateral PHEOs expression. We aimed to answer this by pooling data from two Asian institutions. METHODS: Sixty-seven @entity0 had confirmed C634 germline mutation. Age-dependent penetrance of bilateral PHEO was calculated from date of birth to the date when bilateral PHEO was first diagnosed or when the contralateral gland became a PHEO (if the @entity0 already had one adrenal gland removed). Age-dependent penetrance was estimated by the Kaplan-Meier method and compared by log-rank test. RESULTS: The 4 different @entity4 substitutions included @entity9 ( @entity1 ) (n  =  19, 28.4  %), @entity10 ( @entity5 ) (n  =  36, 38.8  %), @entity11 ( @entity8 ) (n  =  4, 6.0  %), and C634W ( @entity6 ) (n  =  8, 11.9  %). The age-related penetrance of PHEO was similar between @entity9 , @entity10 , @entity11 , and C634W (by age 40, 69.8, 55.2, 25.0, and 56.2  %, respectively) (p  =  0.529). However, the age-related penetrance of bilateral PHEO in @entity9 was significantly higher than @entity10 (by age of 40, 59.3  % vs. 25.2  %, p  =  0.046) or @entity10 , @entity11 , and C634W combined (59.3  % vs. 21.5  %, p  =  0.024). Nevertheless, the accumulative risk of bilateral PHEOs across all four C634 mutations almost approached 100  % over time. CONCLUSION: The accumulative risk of bilateral PHEOs almost reached 100  % but its onset was significantly earlier in @entity9 mutation. These findings implied that those with @entity9 mutation might benefit from earlier screening of contralateral PHEO than other C634 mutations after an unilateral adrenalectomy.

title: XXXX in @entity7 Syndrome: A Two-Institution Experience.

answer: @entity2


abstract: BACKGROUND: An elevated risk of @entity0 /visitor perpetrated violence (type II) against hospital nurses and physicians have been reported, while little is known about @entity4 among other hospital workers, and circumstances surrounding these events. METHODS: Hospital workers (n   =   11,000) in different geographic areas were invited to participate in an anonymous survey. RESULTS: Twelve-month prevalence of @entity4 was 39%; 2,098 of 5,385 workers experienced 1,180 physical assaults, 2,260 physical threats, and 5,576 incidents of @entity2 . Direct care providers were at significant risk, as well as some workers that do not provide direct care. Perpetrator circumstances attributed to violent events included altered @entity3 , behavioral issues, @entity1 /medication withdrawal, dissatisfaction with care. Fear for safety was common among worker victims (38%). Only 19% of events were reported into official reporting systems. CONCLUSIONS: This pervasive occupational safety issue is of great concern and likely extends to @entity0 for whom these workers care for. Am. J. Ind. Med.    2015 Wiley Periodicals, Inc.

title: Physical assault, physical threat, and XXXX perpetrated against hospital workers by @entity0 or visitors in six U.S. hospitals.

answer: @entity2


abstract: BACKGROUND: An elevated risk of @entity0 /visitor perpetrated violence (type II) against hospital nurses and physicians have been reported, while little is known about @entity4 among other hospital workers, and circumstances surrounding these events. METHODS: Hospital workers (n   =   11,000) in different geographic areas were invited to participate in an anonymous survey. RESULTS: Twelve-month prevalence of @entity4 was 39%; 2,098 of 5,385 workers experienced 1,180 physical assaults, 2,260 physical threats, and 5,576 incidents of @entity2 . Direct care providers were at significant risk, as well as some workers that do not provide direct care. Perpetrator circumstances attributed to violent events included altered @entity3 , behavioral issues, @entity1 /medication withdrawal, dissatisfaction with care. Fear for safety was common among worker victims (38%). Only 19% of events were reported into official reporting systems. CONCLUSIONS: This pervasive occupational safety issue is of great concern and likely extends to @entity0 for whom these workers care for. Am. J. Ind. Med.    2015 Wiley Periodicals, Inc.

title: Physical assault, physical threat, and @entity2 perpetrated against hospital workers by XXXX or visitors in six U.S. hospitals.

answer: @entity0


abstract: INTRODUCTION: Targeted spinal @entity2 injections are effective in @entity4 in selected @entity0 populations and carry a small risk of significant adverse neurological outcomes. Recent recommendations are for the use of non-particulate @entity2 agents for all spinal injections to reduce the risk of @entity3 adverse events. Many injections have used a combination of local anaesthetic agent with the @entity2 . At our institutions, we have recently observed interactions between @entity7 and @entity5 combinations ascribed to the incompatibility of the former with alkaline solutions, resulting in rapid crystallisation. This study has further investigated the combinations of commonly used local anaesthetic and @entity2 combinations to determine if such precipitation effects are more widespread. METHODS: The commonly used local anaesthetics ( @entity8 , @entity6 , @entity7 ) and the non-particulate @entity2 @entity5 @entity10 combinations were evaluated macroscopically, microscopically, and pH values measured. Where crystallisation was observed the rate of precipitation and crystal size was measured. Contamination of @entity7 with @entity9 solution was also evaluated. Particulate size of the particulate @entity2 agent @entity12 was evaluated as a comparison. RESULTS: All mixtures of @entity7 and the non-particulate @entity5 @entity10 assessed demonstrated a pH-dependent crystallisation of the solution. No precipitation was demonstrated with the combinations of @entity5 and @entity8 or @entity6 . Contamination of @entity7 with residual @entity9 in a drawing up needle following air clearing had a precipitation effect. CONCLUSION: We describe the effect of crystallisation with the combination of @entity7 and the non-particulate @entity2 , @entity11 , a mixture that has been used in the literature for targeted @entity1 injections. As this may be considered a non-particulate @entity2 /anaesthetic injectate, this would potentially carry increased risk if inadvertent intravascular injection occurred during a targeted spinal injection, as has been described with particulate @entity2 agents. This is due to the elevated pH of @entity5 and the incompatibility of @entity7 with alkaline solutions.

title: @entity7 and XXXX : a potentially dangerous combination for therapeutic @entity1 injections.

answer: @entity5


abstract: INTRODUCTION: Targeted spinal @entity2 injections are effective in @entity4 in selected @entity0 populations and carry a small risk of significant adverse neurological outcomes. Recent recommendations are for the use of non-particulate @entity2 agents for all spinal injections to reduce the risk of @entity3 adverse events. Many injections have used a combination of local anaesthetic agent with the @entity2 . At our institutions, we have recently observed interactions between @entity7 and @entity5 combinations ascribed to the incompatibility of the former with alkaline solutions, resulting in rapid crystallisation. This study has further investigated the combinations of commonly used local anaesthetic and @entity2 combinations to determine if such precipitation effects are more widespread. METHODS: The commonly used local anaesthetics ( @entity8 , @entity6 , @entity7 ) and the non-particulate @entity2 @entity5 @entity10 combinations were evaluated macroscopically, microscopically, and pH values measured. Where crystallisation was observed the rate of precipitation and crystal size was measured. Contamination of @entity7 with @entity9 solution was also evaluated. Particulate size of the particulate @entity2 agent @entity12 was evaluated as a comparison. RESULTS: All mixtures of @entity7 and the non-particulate @entity5 @entity10 assessed demonstrated a pH-dependent crystallisation of the solution. No precipitation was demonstrated with the combinations of @entity5 and @entity8 or @entity6 . Contamination of @entity7 with residual @entity9 in a drawing up needle following air clearing had a precipitation effect. CONCLUSION: We describe the effect of crystallisation with the combination of @entity7 and the non-particulate @entity2 , @entity11 , a mixture that has been used in the literature for targeted @entity1 injections. As this may be considered a non-particulate @entity2 /anaesthetic injectate, this would potentially carry increased risk if inadvertent intravascular injection occurred during a targeted spinal injection, as has been described with particulate @entity2 agents. This is due to the elevated pH of @entity5 and the incompatibility of @entity7 with alkaline solutions.

title: XXXX and @entity5 : a potentially dangerous combination for therapeutic @entity1 injections.

answer: @entity7


abstract: INTRODUCTION: Targeted spinal @entity2 injections are effective in @entity4 in selected @entity0 populations and carry a small risk of significant adverse neurological outcomes. Recent recommendations are for the use of non-particulate @entity2 agents for all spinal injections to reduce the risk of @entity3 adverse events. Many injections have used a combination of local anaesthetic agent with the @entity2 . At our institutions, we have recently observed interactions between @entity7 and @entity5 combinations ascribed to the incompatibility of the former with alkaline solutions, resulting in rapid crystallisation. This study has further investigated the combinations of commonly used local anaesthetic and @entity2 combinations to determine if such precipitation effects are more widespread. METHODS: The commonly used local anaesthetics ( @entity8 , @entity6 , @entity7 ) and the non-particulate @entity2 @entity5 @entity10 combinations were evaluated macroscopically, microscopically, and pH values measured. Where crystallisation was observed the rate of precipitation and crystal size was measured. Contamination of @entity7 with @entity9 solution was also evaluated. Particulate size of the particulate @entity2 agent @entity12 was evaluated as a comparison. RESULTS: All mixtures of @entity7 and the non-particulate @entity5 @entity10 assessed demonstrated a pH-dependent crystallisation of the solution. No precipitation was demonstrated with the combinations of @entity5 and @entity8 or @entity6 . Contamination of @entity7 with residual @entity9 in a drawing up needle following air clearing had a precipitation effect. CONCLUSION: We describe the effect of crystallisation with the combination of @entity7 and the non-particulate @entity2 , @entity11 , a mixture that has been used in the literature for targeted @entity1 injections. As this may be considered a non-particulate @entity2 /anaesthetic injectate, this would potentially carry increased risk if inadvertent intravascular injection occurred during a targeted spinal injection, as has been described with particulate @entity2 agents. This is due to the elevated pH of @entity5 and the incompatibility of @entity7 with alkaline solutions.

title: @entity7 and @entity5 : a potentially dangerous combination for therapeutic XXXX injections.

answer: @entity1


abstract: BACKGROUND: Prophylactic @entity2 ( @entity2 ) and nipple-sparing mastectomy (NSM) both are associated with major risk reduction in @entity1 with high @entity0 risk. Skin-sparing mastectomy followed by nipple-areola complex (NAC) reconstruction is standard of care, but NSM is increasingly being performed. Preservation of the NAC in NSM may increase @entity1 satisfaction. Therefore, we measured NAC sensitivity after NSM and compared @entity1 satisfaction as well as body image after @entity2 with NSM. METHODS: @entity1 who underwent prophylactic bilateral @entity2 or NSM and immediate implant breast reconstruction between 2002 and 2012 were eligible. @entity1 satisfaction was assessed using the Breast-Q reconstruction questionnaire, body image using Hopwood's body image scale (BIS), and satisfaction with the (reconstructed) NAC using a study-specific questionnaire. In the NSM group, NAC sensitivity was assessed using Semmes Weinstein monofilaments with a 5-point scale and compared with NAC sensitivity in a nonoperated control group. RESULTS: The @entity2 group comprised 25 @entity1 (50 SSMs) and the NSM group 20 @entity1 (39 NSMs). Median follow-up was 65 months in the @entity2 group compared with 27 months in the NSM group (P < 0.01). In univariable analyses, Breast-Q scores were favorable in the @entity2 group compared with the NSM group with trends for higher "satisfaction with breasts" (66.2 vs 56.6; P = 0.06) and "satisfaction with outcome" (76.1 vs 61.5; P = 0.09). Mean BIS score of 7.1/30 in the @entity2 group and 9.3/30 in the NSM group (P = 0.35). Adjusted for follow-up, there were no significant differences in Breast-Q scores, nor in BIS scores. Interestingly, satisfaction with the (reconstructed) NAC was similar after @entity2 and NSM. @entity3 was lower in the NSM group (mean score, 1.9; 95% confidence interval, 1.5-2.3) compared with the control group (mean score, 4.7; 95% confidence interval, 4.6-4.9; P < 0.01). CONCLUSIONS: Breast-Q scores regarding satisfaction with breasts and overall outcome were in favor of the @entity2 group. Residual NAC sensitivity after NSM was low. This suggests that @entity2 followed by NAC reconstruction is a balanced alternative to NSM. We observed no significant differences in body image and NAC-specific satisfaction between the NSM and @entity2 groups.

title: XXXX Satisfaction and Nipple-Areola Sensitivity After Bilateral Prophylactic Mastectomy and Immediate Implant Breast Reconstruction in a High Breast Cancer Risk Population: Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy.

answer: @entity1


abstract: UNASSIGNED: Assisted reproductive technology (ART) is being increasingly applied to overcome @entity1 . However, the in vitro production process, the main procedure of ART, can lead to aberrant embryonic development and health-related problems in offspring. Understanding the mechanisms underlying the ART-induced side effects is important to improve the ART process. In this study, we carried out comparative transcriptome profiling between in vivo- (IVO) and in vitro- produced (IVP) @entity0 blastocysts. Our results suggested that aberrant actin organization might be a major factor contributing to the impaired development of IVP embryos. To test this, we examined the effect of actin disorganization on the development of IVP preimplantation embryos. Specific disruption of actin organization by @entity3 (CB) indicated that well-organized actin is essential for in vitro embryonic development. Supplementing the culture medium with 10-9 M @entity4 , a cytoskeletal modulator in adult somatic cells, significantly reversed the disrupted expression patterns of genes related to actin organization, including @entity6 , @entity2 , @entity7 , @entity5 , and Palld. Immunofluorescence analysis showed that @entity4 treatment of IVP embryos significantly improved the distribution and organization of actin filaments (F-actin) from the 8-cell stage onwards. More importantly, we found that @entity4 alleviated the CB-mediated aberrant F-actin distribution and organization and rescued CB-induced impaired embryonic development. This is the first study to indicate that actin disorganization is implicated in impaired development of IVP embryos during the preimplantation stage. We also demonstrated that improving actin organization is a promising strategy to optimize existing IVP systems.

title: Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced XXXX Preimplantation Embryos.

answer: @entity0


abstract: BACKGROUND: Anesthesia-related medication shortages have become increasingly common in the United States. We tested whether a local shortage of pharmacy-prepared @entity2 syringes, replaced by provider-prepared @entity2 , was associated with provider-level changes in @entity2 and @entity1 use and @entity0 -level changes in intraoperative hemodynamics. METHODS: Consecutive @entity0 undergoing general and orthopedic surgery at a tertiary care center were included 1 month before and 1 month after the start of the pharmacy-prepared @entity2 syringe shortage. Lowest mean arterial blood pressure and slowest heart rate were obtained as measures of hemodynamics. Adjusted associations were tested using mixed-effects regression with repeated measures. RESULTS: Three hundred four @entity0 before the shortage and 298 @entity0 after the shortage began were included. The administration of at least 1 bolus of @entity2 was significantly more common before versus during the shortage (148/304 [48.7]% vs 117/298 [39.3]%; P = 0.0199). After adjusting for age, sex, ASA physical status, surgery type, anesthesia provider, and operative duration, @entity0 were significantly less likely to receive @entity2 during the shortage (relative risk [RR] = 0.78 [95% confidence interval {CI}, 0.61-0.96]; P = 0.0198) and more likely to receive a @entity1 bolus (RR = 1.27 [95% CI, 1.02-1.51]; P = 0.0357). @entity0 hemodynamics assessed by slowest heart rate or lowest mean arterial blood pressure did not differ significantly during the shortage. CONCLUSIONS: There was an alteration in medication administration patterns during a shortage of pharmacy-prepared syringes. Changes in @entity2 and @entity1 use were noted; however, @entity0 hemodynamics remained comparable. Provider use patterns were sensitive even to a relative and not absolute medication shortage as observed in this study.

title: The Impact of a Shortage of Pharmacy-Prepared XXXX Syringes on Intraoperative Medication Use.

answer: @entity2


abstract: A review was undertaken of all @entity0 treated for invasive @entity2 in the Wellington region in the period 1975 to 1979. A total of 84 @entity0 were assessed for the results and complications of treatment. Forty-one were stage I, 18 stage II, 18 stage III, and seven stage IV (FIGO staging). Treatment by different combinations of surgery and radiotherapy for each stage are described. Actuarial survival at five years is 54% for all stages. For stage I it is 86%, stage II 54%, and stage III 44%. There were only seven @entity0 in stage IV. Seven @entity0 (8.3%) suffered major complications, mainly gastrointestinal or genitourinary. Most complications occurred in @entity0 treated with a combination of radical surgery followed by high dose external radiotherapy. This treatment should be reserved for selected @entity0 who can be identified as having a very high risk of recurrence in the pelvis after surgery. Invasive @entity1 is a highly treatable disease, with over half the @entity0 surviving free of disease at five years, but screening programmes for early detection are essential.

title: Results of treatment of XXXX in Wellington: 1975-9.

answer: @entity1


abstract: BACKGROUND: The surgical treatment of @entity8 is connected with significant @entity3 . Spinal and general anesthesia as well as peripheral blocks are successfully used in foot surgery. The purpose of this study was to evaluate the influence of local anesthetic infiltration before @entity8 one-day surgery on @entity3 and the need for analgesics. MATERIAL AND METHODS: 134 @entity0 underwent chevron or miniinvasive @entity10 of the first distal metatarsal. After general anesthesia each @entity0 randomly received an infiltration of 7ml of local anesthetic (4 ml of 0.25% @entity5 and 3 ml of 2% @entity7 ) or the same amount of normal saline 15 minutes before the skin incision. Both the @entity0 and the surgeon were blinded. The @entity0 was discharged after approximately 2 hours of observation. 2, 4, 8, 12, 16, 24 and 72 hours after the release of the tourniquet the level of @entity2 was assessed by the visual analogue scale (VAS). Rescue @entity4 , side effects and the use of painkillers were noted. RESULTS: Preemptive local anesthetic infiltration significantly decreased @entity2 during the first 24 hours after the surgery. None of the @entity0 from the injected group and 38 from the placebo group received 100 mg of @entity9 intravenously for rescue @entity4 in the first 2 hours after the release of the tourniquet. During the first 24 hours we noted significantly decreased use of 1000 mg of @entity6 and 100 mg mg of @entity9 orally in the injected group. No systemic adverse effects were noted. One @entity0 from placebo group had @entity1 rush after use of 100 mg @entity9 . CONCLUSIONS: Preemptive local anesthetic infiltration in one-day @entity8 surgery significantly decreases @entity3 . It is safe, efficient and allows fast discharge.

title: [Preemptive local anesthetic infiltration in XXXX one-day surgery].

answer: @entity8


abstract: UNASSIGNED: Renal resistive index (RRI) measured by Doppler ultrasonography is associated with cardiovascular events and mortality in @entity2 , @entity1 , and elderly @entity0 . We studied the factors associated with high RRI (>= 0.70) and its associations with mortality in @entity6 @entity0 without @entity8 . We included 1962 @entity0 with an estimated glomerular filtration rate of 15 to 59 mL/min per 1.73 m(2) who also had RRI measured (January 1, 2005, to October 2011) from an existing @entity6 registry. @entity0 with @entity8 (60%-99% or @entity4 ) were excluded. Multivariable logistic regression model was used to study factors associated with high RRI (>= 0.70), and its association with mortality was studied using Kaplan-Meier plots and Cox proportional hazards model. @entity2 was prevalent in >90% of the @entity0 . In the multivariable logistic regression, older age, female sex, @entity1 , @entity5 , @entity7 , higher systolic blood pressure, and the use of b blockers were associated with higher odds of having RRI>= 0.70. During a median follow-up of 2.2 years, 428 @entity0 died. After adjusting for covariates, RRI>= 0.70 was associated with increased mortality (adjusted hazard ratio, 1.29; 95% confidence interval, 1.02-1.65; P<0.05). This association was more pronounced among younger @entity0 and those with stage 3 @entity6 . Noncardiovascular/non-malignancy-related @entity3 were higher in those with RRI>= 0.70. RRI>= 0.70 is associated with higher mortality in @entity6 @entity0 without clinically significant @entity8 after accounting for other significant risk factors. Its evaluation may allow early identification of those who are at risk thereby potentially preventing or delaying adverse outcomes.

title: Renal Resistive Index and Mortality in XXXX .

answer: @entity6


abstract: PURPOSE: To determine whether the structure-function relationship in @entity2 can be strengthened by using more precise structural and functional measurements combined with individualized structure-function maps and custom sector selection on the optic nerve head (ONH). DESIGN: Cross-sectional study. @entity0 : One eye of each of 23 @entity0 with @entity2 . METHODS: @entity0 were tested twice. Visual fields were collected on a high-resolution 3   * 3   grid (164 locations) using a Zippy Estimation by Sequential Testing test procedure with uniform prior probability to improve the accuracy and precision of scotoma characterization relative to standard methods. Retinal nerve fiber layer (RNFL) thickness was measured using spectral-domain optical coherence tomography (OCT; 4 scans, 2 per visit) with manual removal of blood vessels. Individualized maps, based on biometric data, were used. To customize the areas of the ONH and visual field to correlate, we chose a 30   sector centered on the largest defect shown by OCT and chose @entity1 using the individualized maps. Baseline structure-function correlations were calculated between 24-2 locations (n = 52) of the first tested visual field and RNFL thickness from 1 OCT scan, using the sectors of the Garway-Heath map. We added additional data (averaged visual field and OCT, additional 106 @entity1 and OCT without blood vessels, individualized map, and customized sector) and recomputed the correlations. MAIN OUTCOME MEASURES: Spearman correlation between structure and function. RESULTS: The highest baseline correlation was 0.52 (95% confidence interval [CI], 0.13-0.78) in the superior temporal ONH sector. Improved measurements increased the correlation marginally to 0.58 (95% CI, 0.21-0.81). Applying the individualized map to the large, predefined ONH sectors did not improve the correlation; however, using the individualized map with the single 30   ONH sector resulted in a large increase in correlation to 0.77 (95% CI, 0.47-0.92). CONCLUSIONS: Using more precise visual field and OCT measurements did not improve structure-function correlation in our cohort, but customizing the ONH sector and its associated visual field points substantially improved correlation. We suggest using customized ONH sectors mapped to individually relevant @entity1 to unmask localized structural and functional loss.

title: Enhancing Structure-Function Correlations in XXXX with Customized Spatial Mapping.

answer: @entity2


abstract: UNASSIGNED: Preclinical Research @entity0 with @entity5 often display @entity4 including @entity3 . The visual-signal detection task (VSDT) is a behavioral procedure for assessment of attention in rodents. Male @entity2 were trained in a VSDT and tested with three different noxious stimuli: (i) intraperitoneal injection of @entity7 ; (ii) intraplantar injection of @entity6 ; and (iii) intraplantar injection of complete Freund's adjuvant ( @entity10 ). The muscarinic @entity8 receptor antagonist, @entity11 was also tested as a positive control. @entity11 (0.01-1.0 mg/kg) dose dependently reduced accuracy and increased response latencies during completed trials with higher @entity11 doses increasing omissions. @entity7 (0.56-5.6% ip) also increased response latencies and omissions, although it failed to alter measures of response accuracy. @entity6 produced a transient decrease in accuracy while also increasing both response latency and omissions. @entity10 failed to alter VSDT performance. Although VSDT effects were transient for @entity6 and absent for @entity10 , both treatments produced mechanical @entity9 and paw @entity1 for up to 7 days. These results support the potential for noxious stimuli to produce a @entity5 -related disruption of attention in @entity2 . However, relatively strong noxious stimulation appears necessary to disrupt performance in this version of the VSDT. Drug Dev Res, 2015.    2015 Wiley Periodicals, Inc.

title: Effects of Acute and Sustained XXXX Manipulations on Performance in a Visual-Signal Detection Task of Attention in @entity2 .

answer: @entity5


abstract: UNASSIGNED: Preclinical Research @entity0 with @entity5 often display @entity4 including @entity3 . The visual-signal detection task (VSDT) is a behavioral procedure for assessment of attention in rodents. Male @entity2 were trained in a VSDT and tested with three different noxious stimuli: (i) intraperitoneal injection of @entity7 ; (ii) intraplantar injection of @entity6 ; and (iii) intraplantar injection of complete Freund's adjuvant ( @entity10 ). The muscarinic @entity8 receptor antagonist, @entity11 was also tested as a positive control. @entity11 (0.01-1.0 mg/kg) dose dependently reduced accuracy and increased response latencies during completed trials with higher @entity11 doses increasing omissions. @entity7 (0.56-5.6% ip) also increased response latencies and omissions, although it failed to alter measures of response accuracy. @entity6 produced a transient decrease in accuracy while also increasing both response latency and omissions. @entity10 failed to alter VSDT performance. Although VSDT effects were transient for @entity6 and absent for @entity10 , both treatments produced mechanical @entity9 and paw @entity1 for up to 7 days. These results support the potential for noxious stimuli to produce a @entity5 -related disruption of attention in @entity2 . However, relatively strong noxious stimulation appears necessary to disrupt performance in this version of the VSDT. Drug Dev Res, 2015.    2015 Wiley Periodicals, Inc.

title: Effects of Acute and Sustained @entity5 Manipulations on Performance in a Visual-Signal Detection Task of Attention in XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity4 is a promising platform for single cell oil production. It is well-known for its metabolism oriented toward utilization of hydrophobic substrates and accumulation of storage lipids. Multiple copies of DGA2 under constitutive promoter were introduced into the Q4 strain, a quadruple mutant deleted for the four acyltransferases (  dga1,   dga2,   lro1, and   are1) to improve lipid accumulation. The Q4-DGA2 x3 strain contains three copies of DGA2. Further increase in accumulation was accomplished by blocking the b-oxidation pathway through MFE1 gene deletion yielding Q4-  mfe DGA2 x3. In order to use molasses as a substrate for single cell oil production, @entity2 utilization was established by expressing the @entity0 @entity5 gene yielding Q4- @entity5 DGA2 x3 and Q4-  mfe @entity5 DGA2 x3. During cultivation on @entity2 medium with a @entity1 to @entity3 ratio of 80, both strains accumulated more than 40  % of lipids, which was a 2-fold increase in lipid storage. Q4-  mfe @entity5 DGA2 x3 accumulated more lipids than Q4- @entity5 DGA2 x3 (49 vs. 43  %) but yielded less biomass (13.7 vs. 15  g/L). When grown on 8  % (v/v) molasses, both strains accumulated more than 30  % of lipids after 3  days, while biomass yield was higher in Q4- @entity5 DGA2 x3 (16.4 vs. 14.4  g/L). Further addition of molasses at 72  h resulted in higher biomass yield, 26.6  g/L for Q4- @entity5 DGA2 x3, without modification of lipid content. This work presents genetically modified strains of @entity4 as suitable tools for direct conversion of industrial molasses into value added products based on single cell oils.

title: Single cell oil production on molasses by XXXX strains overexpressing DGA2 in multicopy.

answer: @entity4


abstract: Since 1969 excision of @entity8 and establishment of bile drainage by Roux-en-Y hepaticojejunostomy has been performed in 7 @entity0 whose ages ranged from 10 mo to 11 yr. In 3 @entity0 , the cyst had been treated 5 yr, 4 wk, and 3 wk previously by cystduodenostomy, cystjejunostomy, and cholecystduodenostomy, respectively; further surgery was indicated for @entity2 and severe @entity3 . The other four @entity0 were not acutely ill. All cysts were located distal to the confluence of the right and left hepatic ducts. The volume of the smallest cyst was 25 ml and the largest 500 ml. In all @entity0 a small remnant of distal cyst was not excised to avoid @entity1 and @entity4 . In four @entity0 a remnant of proximal cyst was left attached to the hepatic duct to allow a large biliary intestinal anastomosis and minimize the possibility of stricture. No serious intraoperative problems were encountered. Prolonged drainage (2-3 wk) from Penrose drain sites in two @entity0 were the only postoperative complications. Liver function tests have remained normal in all and no episodes of @entity3 or @entity5 have been noted during follow-up (median: 4.5 yr). This experience supports recent reports that indicate that cyst excision is associated with low mortality and morbidity. Cyst excision is preferred over traditional internal drainage procedures because it (A) eliminates a reservoir for @entity7 , (B) removes a mechanism which allows continuous reflux of pancreatic juice into the cyst, and (C) probably prevents the occurrence of @entity6 which has been noted in 3.0% of @entity0 with @entity8 .

title: Treatment of XXXX by excision.

answer: @entity8


abstract: 1. The influence of micelle formation on @entity4 secretion was assessed by analysing the secretory characteristics of, and interaction between, the natural micelle-forming @entity2 , @entity5 and @entity3 , and the artificial non-micelle-forming @entity2 , @entity7 and @entity6 (both of which are subjected to reductive metabolism), in anaesthetized @entity0 . 2. Competitive secretory interaction between these two classes of @entity4 was demonstrated thereby indicating that they share the same biliary transport system. @entity7 had a lower affinity for the transport system than that of @entity5 and the metabolic derivatives of @entity6 . 3. The (initially determined) biliary secretory maxima for @entity7 (4 . 9 +/- 1 . 9 (S.D.) mumole/min. kg, n = 6) and total ' @entity6 ' in @entity1 replete @entity0 (4 . 2 +/- 1 . 0 mumole/min. kg, n = 16) were both significantly less than those for @entity5 (8 . 0 +/- 1 . 8 mumole/min. kg, n = 16) and total @entity3 in @entity1 replete @entity0 (6 . 9 +/- 1 . 2 mumole/min. kg, n = 12). 4. The initially determined secretory maxima of @entity7 and ' @entity6 ' were elevated by about 30 and 36%, respectively, by an earlier period of @entity5 administration; the most likely explanation (which is supported by independent morphological studies) for this effect is that @entity5 increases the number of functional 'carriers' in the canalicular membrane. When calculated for optimal conditions, the secretory maxima of the non-micelle-forming @entity2 closely approached those of the micelle formers. 5. The above results would seem to indicate that micelle formation (in the hepatocyte, canalicular membrane or bile) is not essential for the effective translocation of @entity4 by the specific canalicular membrane receptors. The results also suggest that the effective concentration of @entity4 in bile (possibly 60--70 times greater in the case of the non-micelle-formers) is not an important determinant of the net secretory performance of conjugated @entity4 . 6. At the same @entity4 secretion rate (3 . 06 mumole/min. kg), the bile flow rate associated with @entity7 (44 . 3 +/- 2 . 7 (S.D. along regression line) microliter/min. kg, n = 38) was significantly greater than that associated with @entity5 (29 . 5 +/- 7 . 7 microliter/min. kg, n = 80) but significantly less than that associated with ' @entity6 ' in @entity1 replete @entity0 (51 . 7 +/- 4 . 8 microliter./min. kg, n = 33), ' @entity6 ' after acute @entity1 depletion (61 . 2 microliter./min. kg, n = 1) and free @entity3 after @entity1 depletion (49 . 8 +/- 9 . 8 microliter/min. kg, n = 92). The extra flow associated with the free @entity2 is derived by means that are largely or entirely independent of their osmotic activity in bile.

title: The influence of micelle formation on XXXX secretion.

answer: @entity4


abstract: The LNCaP @entity0 @entity4 cell line is androgenand stromal-dependent for in vivo growth. We co-inoculated LNCaP cells with @entity0 fetal fibroblasts, isolated from prostate, bone (male), and lung (male and female) derived from 18- to 22-week-old @entity0 fetal tissue, into non-castrate male @entity3 . Co-inoculation of LNCaP with fetal prostatic fibroblasts resulted in high @entity1 take rates (27 of 30, or 90%) 6 to 8 weeks after subcutaneous co-inoculation. Serum @entity5 (PSA) values correlated strongly with wet @entity1 weight (r=0.86). The fetal fibroblast enhancement of @entity1 take rates in vivo was neither gender- nor organ-specific. Fetal fibroblast-conditioned medium (CM) did not have a significant proliferative effect on LNCaP cell growth in vitro. Areas of angiogenesis were demonstrable in all @entity1 , with blood vessels arising at the interface between stromal and @entity1 cells. The fetal fibroblasts, but not the LNCaP cells, expressed significant amounts of the mRNA and protein for @entity2 ( @entity2 ). Treatment of @entity1 -bearing animals with neutralizing antibodies to @entity2 resulted in significant @entity1 growth suppression. These findings indicate that @entity2 is an important mediator of stromal-induced enhancement of @entity0 @entity4 cell growth in vivo.

title: Inhibition of XXXX suppresses the in vivo growth of @entity0 @entity4 .

answer: @entity2


abstract: The LNCaP @entity0 @entity4 cell line is androgenand stromal-dependent for in vivo growth. We co-inoculated LNCaP cells with @entity0 fetal fibroblasts, isolated from prostate, bone (male), and lung (male and female) derived from 18- to 22-week-old @entity0 fetal tissue, into non-castrate male @entity3 . Co-inoculation of LNCaP with fetal prostatic fibroblasts resulted in high @entity1 take rates (27 of 30, or 90%) 6 to 8 weeks after subcutaneous co-inoculation. Serum @entity5 (PSA) values correlated strongly with wet @entity1 weight (r=0.86). The fetal fibroblast enhancement of @entity1 take rates in vivo was neither gender- nor organ-specific. Fetal fibroblast-conditioned medium (CM) did not have a significant proliferative effect on LNCaP cell growth in vitro. Areas of angiogenesis were demonstrable in all @entity1 , with blood vessels arising at the interface between stromal and @entity1 cells. The fetal fibroblasts, but not the LNCaP cells, expressed significant amounts of the mRNA and protein for @entity2 ( @entity2 ). Treatment of @entity1 -bearing animals with neutralizing antibodies to @entity2 resulted in significant @entity1 growth suppression. These findings indicate that @entity2 is an important mediator of stromal-induced enhancement of @entity0 @entity4 cell growth in vivo.

title: Inhibition of @entity2 suppresses the in vivo growth of @entity0 XXXX .

answer: @entity4


abstract: The LNCaP @entity0 @entity4 cell line is androgenand stromal-dependent for in vivo growth. We co-inoculated LNCaP cells with @entity0 fetal fibroblasts, isolated from prostate, bone (male), and lung (male and female) derived from 18- to 22-week-old @entity0 fetal tissue, into non-castrate male @entity3 . Co-inoculation of LNCaP with fetal prostatic fibroblasts resulted in high @entity1 take rates (27 of 30, or 90%) 6 to 8 weeks after subcutaneous co-inoculation. Serum @entity5 (PSA) values correlated strongly with wet @entity1 weight (r=0.86). The fetal fibroblast enhancement of @entity1 take rates in vivo was neither gender- nor organ-specific. Fetal fibroblast-conditioned medium (CM) did not have a significant proliferative effect on LNCaP cell growth in vitro. Areas of angiogenesis were demonstrable in all @entity1 , with blood vessels arising at the interface between stromal and @entity1 cells. The fetal fibroblasts, but not the LNCaP cells, expressed significant amounts of the mRNA and protein for @entity2 ( @entity2 ). Treatment of @entity1 -bearing animals with neutralizing antibodies to @entity2 resulted in significant @entity1 growth suppression. These findings indicate that @entity2 is an important mediator of stromal-induced enhancement of @entity0 @entity4 cell growth in vivo.

title: Inhibition of @entity2 suppresses the in vivo growth of XXXX @entity4 .

answer: @entity0


abstract: We evaluated the results of a treatment protocol that consisted of neoadjuvant hormonal therapy followed by radical retropubic prostatectomy (RRP) for clinical stage T3 (cT3) @entity2 . Sixty-six @entity0 with cT3 @entity2 underwent staging procedures that included metastatic work-up and evaluation under anesthesia. Neoadjuvant hormonal treatment was given for 3 to 6 months, followed by re-evaluation under anesthesia. @entity0 considered to have a resectable prostate following neoadjuvant treatment underwent operation. Disease-free survival [prostate-specific antigen (PSA) < 0.1 ng/ml] was calculated by the Kaplan-Meier method for cT3 @entity0 and for a group of @entity0 with clinical stage 1 and 2 disease (cT1-2), who underwent RRP without neoadjuvant hormonal therapy. @entity0 with pT3 disease in both groups received early adjuvant radiation treatment. @entity0 in the cT3 group who were not clinically downstaged were treated with radiation. @entity0 with positive lymph nodes continued hormonal therapy. The pretreatment PSA for the cT3 group was 43.6    55.6 ng/ml, and 10.64    7.18 ng/ml for the cT1-2 group (p < 0.05). Of 66 cT3 @entity0 , 53 (80%) were clinically downstaged and operated on and 47 (71%) underwent RRP. At 36 months, there was no significant difference in the PSA relapse rate between these two groups; both had significantly lower rates than did @entity0 in the cT3 without RRP. At 48 months, 79% (21 @entity0 ) of the @entity0 in the cT3-RRP group were disease free compared with 50% of those in the cT3 without RRP (4 @entity0 ). Neoadjuvant hormonal therapy for stage cT3 @entity2 selects @entity0 whose @entity1 can be controlled by RRP for an extended period of time.

title: Neoadjuvant hormonal therapy and radical prostatectomy in the treatment of clinical stage T3 XXXX .

answer: @entity2


abstract: The objective of this work was to study the mechanism of @entity1 development under the influence of restriction of diet. Useful information is presented about the pathologic features associated with diet restriction in a @entity4 animal model of @entity3 . There were 96 @entity4 of two genotypes, Ross 308 and Cobb 500, in the experiment. The control group was fed a standard mixture ad libitum (ADL). The first experimental group, under restriction from the age of 2 weeks, was fed 80% ADL. The second experimental group was fed 65% ADL from the age of 2 weeks. There were 16 animals in each group. The experiment lasted 5 weeks. Liver parenchyma samples were obtained at the age of 35 days by the necropsy method and then processed by standard histologic methods. The slices were stained by standard staining: @entity5 - @entity6 and by Sirius red kit for collagen type I and reticulin visualization. Hepatocyte diameter and the proportion of interstitial tissue to the parenchyma of the liver were measured objectively. @entity2 was observed after 35 days of restriction. Hepatocyte diameter was significantly influenced by sex, genotype, and the experimental group. The proportion of interstitial tissue to the @entity1 was highly influenced by genotype and group, but there were no interactions. An increase in the @entity2 histologic grade is associated with inflammatory changes, with decrease of hepatocyte diameter and with a decreasing proportion of interstitial tissue to the @entity1 . The results show that early restriction is not associated with the development of @entity0 of the liver tissue.

title: Experimental study of @entity3 ( @entity3 ) on a model of starving @entity4 : is generalization of @entity2 accompanied by XXXX of the liver tissue?

answer: @entity0