abstract: BACKGROUND: Cardiac evaluation before kidney transplantation is recommended, but no unequivocal screening strategy has yet been identified. We investigated if coronary artery @entity3 score (CACS) can replace @entity1 factor assessment in selection of kidney transplantation candidates for cardiac evaluation and the choice of noninvasive modality for diagnosing obstructive @entity2 ( @entity2 ). METHODS: We conducted a prospective study of 167 @entity0 referred for pretransplantation cardiac evaluation. @entity0 underwent risk factor assessment, CACS, coronary computed tomography angiography (CCTA), single-photon emission computed tomography (SPECT), and invasive coronary angiography. In total, 138 @entity0 completed all diagnostic tests. RESULTS: In @entity0 with @entity2 (22%), the number of risk factors and CACS score were higher than that in @entity0 without @entity2 . The accuracy evaluated by the receiver-operating characteristic curve was higher for CACS than for risk factors, 0.85 versus 0.71 (P = 0.01). Adding CACS to the risk factor increased correct categorical net reclassification (0.58, P < 0.0001). Combining risk factors (>= 3) with SPECT to identify @entity0 with obstructive @entity2 resulted in less sensitivity (47% vs 80%) and higher specificity (94% vs 74%), compared with CCTA. In @entity0 with low CACS (<400), SPECT had a lower sensitivity than CCTA (60% versus 80%) but the same specificity (80%). In @entity0 with high CACS (>= 400), SPECT had lower sensitivity than CCTA (50% vs 100%) and higher specificity (88% vs 8%). CONCLUSIONS: In kidney transplantation candidates, CACS outperformed risk factor assessment for predicting obstructive @entity2 and is a better tool for selecting @entity0 and guiding the choice of noninvasive diagnostic modality in @entity2 .

title: Coronary XXXX Score May Replace Cardiovascular Risk Factors as Primary Risk Stratification Tool Before Kidney Transplantation.

answer: @entity3


abstract: Unlike the English National Joint Registry (NJR) for arthroplasty, no surgeon driven national database currently exists for ligament surgery in England. Therefore information on outcome and adverse events following anterior cruciate ligament (ACL) surgery is limited to case series. This restricts the ability to make formal recommendations upon surgical care. Prospectively collected data, which is routinely collected on every @entity4 @entity0 admitted to hospital in England, was analysed to determine national rates of 90-day symptomatic @entity2 ( @entity2 ), @entity3 ( @entity3 ) rate, 30-day wound @entity1 and readmission rates following primary ACL reconstruction between March 2008 and February 2010 (13,941 operations, annual incidence 13.5 per 100,000 English population). 90-day @entity2 and @entity3 rates were 0.30% (42) and 0.18% (25) respectively. There were no in-hospital deaths. 0.75% (104) of the consecutive @entity0 cohort had a wound complication recorded. 0.25% (35) underwent a further procedure to wash out the infected knee joint and 1.36% (190) were readmitted to an orthopaedic ward within 30days. This is the first national comprehensive study of the incidence of significant complications following ACL surgery in England. This should allow meaningful interpretation of future baseline data supporting the development of a national ligament registry.

title: Complications following anterior cruciate ligament reconstruction in the English XXXX .

answer: @entity4


abstract: RATIONALE AND OBJECTIVES: The aim of this study was to assess the feasibility of thermally cross-linked superparamagnetic @entity7 nanoparticle contrast (TCL-SPION) in magnetic resonance (MR) imaging (MRI) for the detection of lymph node @entity1 in experimental model. MATERIALS AND METHODS: B16F1 @entity0 @entity4 cells were subcutaneously injected into the thighs of C57BL/6 @entity3 (n = 10). MRI was performed 21 days after @entity2 injection using a 4.7-T MR scanner. In vivo MRI was performed before and after the intravenous administration of TCL-SPION using T2 fast spin-echo and T2 gradient-echo pulse sequences. Then, ex vivo MR images were obtained for resected inguinal lymph nodes (n = 18) using the same pulse sequences as for in vivo imaging. On the basis of @entity5 and @entity6 staining results, the lymph nodes were classified into three groups: group 1, nonmetastatic; group 2, @entity2 volume <50% of the resected sample; and group 3, @entity2 volume >50% of the resected sample. Size, signal-to-background ratio, and enhancement pattern were evaluated in each of the three groups on ex vivo images. RESULTS: The findings observed on ex vivo MR images of 18 inguinal lymph nodes were compared with histopathologic findings. All nodes were classified into three groups: group 1, n = 6; group 2, n = 5; and group 3, n = 7. The sizes of the lymph nodes in group 1 were significantly different from the sizes of those in group 3 (P = .014), but there was no significant difference in lymph node sizes between groups 1 and 2 (P = .792). Signal-to-background ratios of samples in groups 2 and 3 were significantly higher than those of samples in group 1 (P = .045 and P = .007, respectively). Each group of lymph nodes showed characteristic enhancement patterns that were well correlated between the images and pathology, except for one node. CONCLUSIONS: The features and extent of @entity1 in the lymph nodes corresponded to those observed on TCL-SPION-enhanced MR images. TCL-SPION-enhanced MRI is useful for the detection and estimation of lymph node @entity1 .

title: TCL-SPION-enhanced MRI for the detection of lymph node XXXX in @entity3 experimental model.

answer: @entity1


abstract: RATIONALE AND OBJECTIVES: The aim of this study was to assess the feasibility of thermally cross-linked superparamagnetic @entity7 nanoparticle contrast (TCL-SPION) in magnetic resonance (MR) imaging (MRI) for the detection of lymph node @entity1 in experimental model. MATERIALS AND METHODS: B16F1 @entity0 @entity4 cells were subcutaneously injected into the thighs of C57BL/6 @entity3 (n = 10). MRI was performed 21 days after @entity2 injection using a 4.7-T MR scanner. In vivo MRI was performed before and after the intravenous administration of TCL-SPION using T2 fast spin-echo and T2 gradient-echo pulse sequences. Then, ex vivo MR images were obtained for resected inguinal lymph nodes (n = 18) using the same pulse sequences as for in vivo imaging. On the basis of @entity5 and @entity6 staining results, the lymph nodes were classified into three groups: group 1, nonmetastatic; group 2, @entity2 volume <50% of the resected sample; and group 3, @entity2 volume >50% of the resected sample. Size, signal-to-background ratio, and enhancement pattern were evaluated in each of the three groups on ex vivo images. RESULTS: The findings observed on ex vivo MR images of 18 inguinal lymph nodes were compared with histopathologic findings. All nodes were classified into three groups: group 1, n = 6; group 2, n = 5; and group 3, n = 7. The sizes of the lymph nodes in group 1 were significantly different from the sizes of those in group 3 (P = .014), but there was no significant difference in lymph node sizes between groups 1 and 2 (P = .792). Signal-to-background ratios of samples in groups 2 and 3 were significantly higher than those of samples in group 1 (P = .045 and P = .007, respectively). Each group of lymph nodes showed characteristic enhancement patterns that were well correlated between the images and pathology, except for one node. CONCLUSIONS: The features and extent of @entity1 in the lymph nodes corresponded to those observed on TCL-SPION-enhanced MR images. TCL-SPION-enhanced MRI is useful for the detection and estimation of lymph node @entity1 .

title: TCL-SPION-enhanced MRI for the detection of lymph node @entity1 in XXXX experimental model.

answer: @entity3


abstract: Primary hepatothiasis ( @entity8 ) and @entity5 ( @entity5 ) are two terms describing the different aspects of the same disease, with @entity8 emphasizing the pathologic changes and @entity5 emphasizing the clinical presentation and @entity2 . It is predominantly a disease of the Far East. In the 1960s, it was the third most common cause of emergency abdominal surgery at a university hospital in Hong Kong. Thereafter, its incidence has decreased considerably, possibly due to improved standards of living and Westernized diet. Clinically, @entity0 may present acutely with recurrent @entity11 and its possible complications, such as @entity14 and @entity7 , or with chronic complications, such as @entity4 . Pathologically, it is characterized by pigmented @entity6 stones within dilated intrahepatic bile ducts featuring @entity2 , mural @entity3 , and proliferation of peribiliary glands, without @entity12 . Episodes of @entity2 cumulate in sclerosing @entity9 and parenchymal @entity3 resulting from collapse and @entity10 . Mass-forming @entity15 and @entity1 like @entity13 and @entity4 are increasingly recognized complications. Modern imaging techniques allow definitive diagnosis, accurate assessment for treatment planning, and detection of complications. A multidisciplinary team approach (interventional endoscopist, interventional radiologist, hepatobiliary surgeon, and intensivists) is important for optimal @entity0 outcome.

title: Hepatolithiasis and the syndrome of XXXX : clinical, radiologic, and pathologic features.

answer: @entity5


abstract: OBJECTIVES/HYPOTHESIS: To characterize perceived voice handicap of @entity0 diagnosed with @entity1 and review treatment success. STUDY DESIGN: Retrospective study. METHODS: Two hundred seventy-five @entity0 diagnosed with @entity1 (January 2007-January 2009) were reviewed from a preexisting clinical database. Outcome measures included pre/post-treatment Voice Handicap Index-10 and data from a voice therapy discharge survey. RESULTS: Five groups emerged from the data set. Group A: @entity0 who had no follow-up (69%). After removing group A from the data set, the following groups emerged: group B: @entity0 who had no treatment but some follow-up (31%); group C: @entity0 who had voice therapy only (44%); group D: @entity0 who had surgery only (15%); and group E: @entity0 who had voice therapy first and subsequent surgery (9%). The perceived voice handicap severity was worse for groups C and D compared to groups A, B, and E. Treatment success outcomes showed that groups C (36%), D (56%), and E (17%) only improved marginally. However, 81% of @entity0 diagnosed with @entity1 believed that voice therapy helped them but only by 48%. CONCLUSIONS: Treatment success for age-related @entity1 is poor to moderately poor for this cohort of @entity0 .

title: Treatment success for age-related XXXX .

answer: @entity1


abstract: Subtrochanteric @entity3 of the femur below an arthritic hip are uncommon and challenging to orthopedic surgeons. Most of these @entity3 occur in elderly @entity0 with advanced @entity2 . The treatment choices consist of treatment of the @entity3 and the above hip joint versus treatment of the @entity3 alone. This study evaluates the clinical and radiological outcomes of arthroplasties performed to treat both conditions in a single surgery with the use of a cementless modular revision stem. Twelve @entity4 of 12 @entity0 (9 @entity0 , 3 @entity0 ) with a mean age of 76.4 years (range, 62-88 years) were treated with cementless modular revision stems. Total hip arthroplasty was performed with cementless femoral and acetabular component fixation. All hips received the same femoral and acetabular implants. All @entity0 had comorbidities and the average American Society of Anesthesiologists score was 2.3 (range, 1-3). Ten of the 12 hips (83%) required an assistance device for ambulation before the @entity1 . There were 2 Dorr Type A (17%), 3 Dorr type B (25%), and 7 Dorr type C (58%) femora. The mean postoperative Harris Hip Score was 83 (range, 72-92) with a mean follow-up of 4.3 years (range, 2-7 years). At final follow-up, 9 hips (75%) were ambulatory without support (P=.016). Ten hips (83%) were able to both ambulate and walk up and down stairs. Two hips (17%) were able to ambulate but could not climb and descend stairs. Union was achieved in all femora at an average of 22.3 weeks (range, 16-32 weeks). Radiographic findings demonstrated stable ingrowth of the femoral prosthesis with no evidence of subsidence in 11 hips (92%). The average Engh score for all femora was 20.2 (range, 10-26). There was no relationship between the bone morphology (Dorr type) of the femoral medullary canal and the bone ingrowth scores of Engh (P=.639).

title: The use of a cementless modular stem in the treatment of XXXX in conjunction with ipsilateral coxarthrosis.

answer: @entity4


abstract: The goal of this study was to evaluate the long-term survivorship of primary @entity3 (THA) using Harris-Galante porous I acetabular and @entity5 . From July 1985 to December 1991, we performed primary cementless THA on 76 hips (70 @entity0 ). Twenty-nine @entity0 (31 hips) died due to causes unrelated to the THA, and 6 @entity0 (7 hips) were lost to follow-up. Of 76 hips (70 @entity0 ) studied, 38 hips (35 @entity0 ) were available for follow-up at a mean 22.5 years (range, 19-25 years) postoperatively. Mean @entity0 age at index procedure was 51.2 years (range, 42-65 years). Average Harris Hip Score was 40.5 points preoperatively and 85.8 points at final follow-up. No @entity0 had an early or late postoperative deep @entity2 . Radiographically, the acetabular component fixation was stable in all 38 hips. The femoral component was bone-ingrown in 26 hips, stable-fibrous in 10, and unstable in 2. One unstable hip required revision of the femoral component. Dissociation of the @entity4 liner occurred in 3 hips without @entity1 of the metal locking tines and required revision of the @entity4 liner and the articular head. A total of 4 hips had documented revision, and 1 femoral component failed radiographically. The survival rate with the endpoint defined as revision surgery and radiographic loosening was 86.8% at 22.5 years of follow-up. Mean @entity4 wear was 0.085 mm/year (range, 0.031-0.15 mm). This study found that the Harris-Galante porous I acetabular and @entity5 produce excellent long-term results.

title: The XXXX : a 19- to 25-year follow-up study.

answer: @entity3


abstract: OBJECTIVES/HYPOTHESIS: Recent studies have suggested that @entity5 secrete exotoxins that may act as superantigens and upregulate the variable beta region of lymphocytes in @entity7 ( @entity7 ). The aim of this study was to add further information for correlating the presence of staphylococcal species and the upregulation of the V(b) region of both nasal polyp lymphocytes and peripheral blood lymphocytes. Furthermore, IgE-mediated @entity2 directed against these exotoxins produces an additional independent immunologic mechanism in upregulating the inflammatory response in the lateral wall of the nose in @entity7 . STUDY DESIGN: Prospective study. METHODS: Nasal @entity6 were harvested from 38 @entity0 with @entity7 . Eleven @entity0 were studied for the correlation of exotoxin from staphylococcal species and the variable beta region of lymphocytes in both the nasal polyp lymphocytes and corresponding peripheral blood lymphocytes. Eight additional @entity0 with @entity7 were studied for local and systemic IgE-mediated immunity directed against @entity5 exotoxins. Flow cytometry was used to analyze the V(b) repertoire of polyp-derived CD3-positive lymphocytes from 11 @entity0 . @entity5 was isolated from nine @entity0 , and coagulase-negative @entity5 was isolated from two @entity0 in whom at least 1   10(6) T cells could be isolated from their @entity4 . A quantitative assay for IgE was developed to study the levels of this immunoglobulin directed against @entity5 exotoxins in both the nasal polyp and the peripheral blood lymphocytes of 11 @entity0 and in the nasal mucus and serum of eight additional @entity0 . RESULTS: Eleven @entity0 had T-cell V(b) clonal expansion. @entity5 exotoxin upregulated the corresponding V(b) region of lymphocytes in both the nasal polyp T cells as well as the T cells from the peripheral blood in nine @entity0 , and two @entity0 with coagulase-negative @entity5 also demonstrated upregulation of the V(b) region in the @entity4 in the absence of exotoxins. In one @entity0 , in vivo exotoxin was isolated, which correlated with the in vitro isolation from the organism itself. IgE directed against staphylococcal enterotoxin B (SEB) and @entity3 toxin was significantly elevated in the sera of @entity0 with @entity7 (P < .0001) as compared with the sera of age-related healthy control subjects; IgE directed against staphylococcal enterotoxin A and SEB (P = .0047) was significantly elevated in the mucus of eight @entity0 with @entity7 as compared with the nasal mucus of healthy controls. CONCLUSIONS: This study augments our understanding of the potential role of @entity5 exotoxins behaving as superantigens in the lateral wall of the nose in @entity7 . Furthermore, local nasal IgE directed against these exotoxins may create a @entity1 in the lateral wall of the nose. These two immunologic mechanisms are independent but may be additive in the inflammatory process in @entity7 .

title: Further observations on the role of @entity5 exotoxins and IgE in the pathogenesis of XXXX .

answer: @entity7


abstract: OBJECTIVES/HYPOTHESIS: Recent studies have suggested that @entity5 secrete exotoxins that may act as superantigens and upregulate the variable beta region of lymphocytes in @entity7 ( @entity7 ). The aim of this study was to add further information for correlating the presence of staphylococcal species and the upregulation of the V(b) region of both nasal polyp lymphocytes and peripheral blood lymphocytes. Furthermore, IgE-mediated @entity2 directed against these exotoxins produces an additional independent immunologic mechanism in upregulating the inflammatory response in the lateral wall of the nose in @entity7 . STUDY DESIGN: Prospective study. METHODS: Nasal @entity6 were harvested from 38 @entity0 with @entity7 . Eleven @entity0 were studied for the correlation of exotoxin from staphylococcal species and the variable beta region of lymphocytes in both the nasal polyp lymphocytes and corresponding peripheral blood lymphocytes. Eight additional @entity0 with @entity7 were studied for local and systemic IgE-mediated immunity directed against @entity5 exotoxins. Flow cytometry was used to analyze the V(b) repertoire of polyp-derived CD3-positive lymphocytes from 11 @entity0 . @entity5 was isolated from nine @entity0 , and coagulase-negative @entity5 was isolated from two @entity0 in whom at least 1   10(6) T cells could be isolated from their @entity4 . A quantitative assay for IgE was developed to study the levels of this immunoglobulin directed against @entity5 exotoxins in both the nasal polyp and the peripheral blood lymphocytes of 11 @entity0 and in the nasal mucus and serum of eight additional @entity0 . RESULTS: Eleven @entity0 had T-cell V(b) clonal expansion. @entity5 exotoxin upregulated the corresponding V(b) region of lymphocytes in both the nasal polyp T cells as well as the T cells from the peripheral blood in nine @entity0 , and two @entity0 with coagulase-negative @entity5 also demonstrated upregulation of the V(b) region in the @entity4 in the absence of exotoxins. In one @entity0 , in vivo exotoxin was isolated, which correlated with the in vitro isolation from the organism itself. IgE directed against staphylococcal enterotoxin B (SEB) and @entity3 toxin was significantly elevated in the sera of @entity0 with @entity7 (P < .0001) as compared with the sera of age-related healthy control subjects; IgE directed against staphylococcal enterotoxin A and SEB (P = .0047) was significantly elevated in the mucus of eight @entity0 with @entity7 as compared with the nasal mucus of healthy controls. CONCLUSIONS: This study augments our understanding of the potential role of @entity5 exotoxins behaving as superantigens in the lateral wall of the nose in @entity7 . Furthermore, local nasal IgE directed against these exotoxins may create a @entity1 in the lateral wall of the nose. These two immunologic mechanisms are independent but may be additive in the inflammatory process in @entity7 .

title: Further observations on the role of XXXX exotoxins and IgE in the pathogenesis of @entity7 .

answer: @entity5


abstract: OBJECTIVES: Esophageal strictures and @entity2 are complications of @entity1 , which are difficult to manage. The efficacy of @entity5 ( @entity5 ) for palliation of @entity6 and @entity2 was investigated prospectively. METHODS: Forty-three @entity5 were inserted in 41 @entity0 with @entity6 or @entity2 . Our series included 32 @entity0 and nine @entity0 , of whom median age was 61.4 years. Twenty nine stents were inserted for stricture, ten for esophago-tracheal @entity2 , and four @entity3 . Stents were inserted endoscopically under fluoroscopic control. RESULTS: @entity5 implantation was technically successful in 40 of 41 @entity0 . A second stenting was needed in two @entity0 . Median @entity4 score improved from 3.4 to 1.3. The covered @entity5 was succesful in completely sealing 85.7% of the @entity2 . Complication occurred in 11 (26.8%) @entity0 . Especially in the case of @entity1 stenoses in the distal esophagus, complication rate was higher (44%). In total six @entity0 (14.6%) died after stent placement during early postoperative period. Procedure-related mortality was 4.8% (2/41). CONCLUSIONS: We conclude that treatment of @entity1 , including @entity2 , with @entity5 is an alternative palliative procedure. Furthermore @entity5 implantation seems more safe in the case of @entity1 stenoses locating in the middle esophagus.

title: The efficacy of @entity5 for palliation of @entity6 and XXXX .

answer: @entity2


abstract: OBJECTIVES: Esophageal strictures and @entity2 are complications of @entity1 , which are difficult to manage. The efficacy of @entity5 ( @entity5 ) for palliation of @entity6 and @entity2 was investigated prospectively. METHODS: Forty-three @entity5 were inserted in 41 @entity0 with @entity6 or @entity2 . Our series included 32 @entity0 and nine @entity0 , of whom median age was 61.4 years. Twenty nine stents were inserted for stricture, ten for esophago-tracheal @entity2 , and four @entity3 . Stents were inserted endoscopically under fluoroscopic control. RESULTS: @entity5 implantation was technically successful in 40 of 41 @entity0 . A second stenting was needed in two @entity0 . Median @entity4 score improved from 3.4 to 1.3. The covered @entity5 was succesful in completely sealing 85.7% of the @entity2 . Complication occurred in 11 (26.8%) @entity0 . Especially in the case of @entity1 stenoses in the distal esophagus, complication rate was higher (44%). In total six @entity0 (14.6%) died after stent placement during early postoperative period. Procedure-related mortality was 4.8% (2/41). CONCLUSIONS: We conclude that treatment of @entity1 , including @entity2 , with @entity5 is an alternative palliative procedure. Furthermore @entity5 implantation seems more safe in the case of @entity1 stenoses locating in the middle esophagus.

title: The efficacy of @entity5 for palliation of XXXX and @entity2 .

answer: @entity6


abstract: OBJECTIVES: Esophageal strictures and @entity2 are complications of @entity1 , which are difficult to manage. The efficacy of @entity5 ( @entity5 ) for palliation of @entity6 and @entity2 was investigated prospectively. METHODS: Forty-three @entity5 were inserted in 41 @entity0 with @entity6 or @entity2 . Our series included 32 @entity0 and nine @entity0 , of whom median age was 61.4 years. Twenty nine stents were inserted for stricture, ten for esophago-tracheal @entity2 , and four @entity3 . Stents were inserted endoscopically under fluoroscopic control. RESULTS: @entity5 implantation was technically successful in 40 of 41 @entity0 . A second stenting was needed in two @entity0 . Median @entity4 score improved from 3.4 to 1.3. The covered @entity5 was succesful in completely sealing 85.7% of the @entity2 . Complication occurred in 11 (26.8%) @entity0 . Especially in the case of @entity1 stenoses in the distal esophagus, complication rate was higher (44%). In total six @entity0 (14.6%) died after stent placement during early postoperative period. Procedure-related mortality was 4.8% (2/41). CONCLUSIONS: We conclude that treatment of @entity1 , including @entity2 , with @entity5 is an alternative palliative procedure. Furthermore @entity5 implantation seems more safe in the case of @entity1 stenoses locating in the middle esophagus.

title: The efficacy of XXXX for palliation of @entity6 and @entity2 .

answer: @entity5


abstract: @entity9 ( @entity9 ) was shown to lower blood pressure in @entity1 models of @entity2 . Thus, there is evidence that-besides its chelating properties- @entity9 has a direct vascular effect, e.g. through scavenging of reactive @entity0 species (ROS). We speculated that, in addition, intracellular @entity4 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9 on @entity3 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity1 aorta. Intracellular free @entity3 concentration ([ @entity3 ](i)) was measured with @entity6 AM. In a first series of experiments @entity9 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity3 ](i) (P<0.001) which was almost completely blunted by the @entity4 channel blocker @entity8 or the intracellular @entity4 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9 (10(-11) to 10(-6)M), the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9 . Preincubation of VSMCs with @entity9 (10(-6)M) for 60min reduced basal [ @entity3 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) by 66%, @entity9 (10(-6)M) had no additional suppressive effect on [ @entity3 ](i). The results suggest that @entity9 acutely raises [ @entity3 ](i) by stimulating transmembrane @entity4 influx via L-type @entity4 channels and by @entity4 release from intracellular stores followed by a decrease in [ @entity3 ](i) probably due to cellular @entity4 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity7 , @entity9 may exert its @entity5 effect through decreasing total cell @entity4 , thereby attenuating the vasoconstrictor-induced rise in [ @entity3 ](i) in VSMCs.

title: Interaction of @entity9 ( @entity9 ) with @entity7 on XXXX mobilization in vascular smooth muscle cells.

answer: @entity4


abstract: @entity9 ( @entity9 ) was shown to lower blood pressure in @entity1 models of @entity2 . Thus, there is evidence that-besides its chelating properties- @entity9 has a direct vascular effect, e.g. through scavenging of reactive @entity0 species (ROS). We speculated that, in addition, intracellular @entity4 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9 on @entity3 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity1 aorta. Intracellular free @entity3 concentration ([ @entity3 ](i)) was measured with @entity6 AM. In a first series of experiments @entity9 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity3 ](i) (P<0.001) which was almost completely blunted by the @entity4 channel blocker @entity8 or the intracellular @entity4 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9 (10(-11) to 10(-6)M), the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9 . Preincubation of VSMCs with @entity9 (10(-6)M) for 60min reduced basal [ @entity3 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) by 66%, @entity9 (10(-6)M) had no additional suppressive effect on [ @entity3 ](i). The results suggest that @entity9 acutely raises [ @entity3 ](i) by stimulating transmembrane @entity4 influx via L-type @entity4 channels and by @entity4 release from intracellular stores followed by a decrease in [ @entity3 ](i) probably due to cellular @entity4 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity7 , @entity9 may exert its @entity5 effect through decreasing total cell @entity4 , thereby attenuating the vasoconstrictor-induced rise in [ @entity3 ](i) in VSMCs.

title: Interaction of XXXX ( @entity9 ) with @entity7 on @entity4 mobilization in vascular smooth muscle cells.

answer: @entity9


abstract: @entity9 ( @entity9 ) was shown to lower blood pressure in @entity1 models of @entity2 . Thus, there is evidence that-besides its chelating properties- @entity9 has a direct vascular effect, e.g. through scavenging of reactive @entity0 species (ROS). We speculated that, in addition, intracellular @entity4 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9 on @entity3 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity1 aorta. Intracellular free @entity3 concentration ([ @entity3 ](i)) was measured with @entity6 AM. In a first series of experiments @entity9 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity3 ](i) (P<0.001) which was almost completely blunted by the @entity4 channel blocker @entity8 or the intracellular @entity4 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9 (10(-11) to 10(-6)M), the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9 . Preincubation of VSMCs with @entity9 (10(-6)M) for 60min reduced basal [ @entity3 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) by 66%, @entity9 (10(-6)M) had no additional suppressive effect on [ @entity3 ](i). The results suggest that @entity9 acutely raises [ @entity3 ](i) by stimulating transmembrane @entity4 influx via L-type @entity4 channels and by @entity4 release from intracellular stores followed by a decrease in [ @entity3 ](i) probably due to cellular @entity4 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity7 , @entity9 may exert its @entity5 effect through decreasing total cell @entity4 , thereby attenuating the vasoconstrictor-induced rise in [ @entity3 ](i) in VSMCs.

title: Interaction of @entity9 ( XXXX ) with @entity7 on @entity4 mobilization in vascular smooth muscle cells.

answer: @entity9


abstract: @entity9 ( @entity9 ) was shown to lower blood pressure in @entity1 models of @entity2 . Thus, there is evidence that-besides its chelating properties- @entity9 has a direct vascular effect, e.g. through scavenging of reactive @entity0 species (ROS). We speculated that, in addition, intracellular @entity4 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9 on @entity3 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity1 aorta. Intracellular free @entity3 concentration ([ @entity3 ](i)) was measured with @entity6 AM. In a first series of experiments @entity9 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity3 ](i) (P<0.001) which was almost completely blunted by the @entity4 channel blocker @entity8 or the intracellular @entity4 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9 (10(-11) to 10(-6)M), the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9 . Preincubation of VSMCs with @entity9 (10(-6)M) for 60min reduced basal [ @entity3 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity7 (10(-8)M)-induced rise in [ @entity3 ](i) by 66%, @entity9 (10(-6)M) had no additional suppressive effect on [ @entity3 ](i). The results suggest that @entity9 acutely raises [ @entity3 ](i) by stimulating transmembrane @entity4 influx via L-type @entity4 channels and by @entity4 release from intracellular stores followed by a decrease in [ @entity3 ](i) probably due to cellular @entity4 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity7 , @entity9 may exert its @entity5 effect through decreasing total cell @entity4 , thereby attenuating the vasoconstrictor-induced rise in [ @entity3 ](i) in VSMCs.

title: Interaction of @entity9 ( @entity9 ) with XXXX on @entity4 mobilization in vascular smooth muscle cells.

answer: @entity7


abstract: The optimal management of asparaginase-associated @entity4 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity0 with @entity5 ( @entity5 ) with asparaginase-related @entity6 ( @entity6 ) treated at Dana-Farber @entity1 Institute on clinical trials for newly diagnosed @entity5 between 1991-2008. Of 548 @entity0 , 43 (8%) had @entity6 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity0 . @entity2 occurred in 1  6% of @entity0 . Age was the only significant predictor of @entity6 , with those aged >30years at very high risk ( @entity6 rate 42%). 74% of @entity0 received low molecular weight heparin after @entity6 . Complications of anticoagulation included @entity7 (9%), @entity8 (2%) and, in two adult @entity0 , major @entity3 . Thirty @entity0 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity0 experienced recurrent @entity6 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity0 with @entity6 was 85  6% compared with 88  2% for those without @entity6 (P=0  36). This study confirms that, after @entity6 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity6 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related @entity4 in paediatric and adult @entity0 with XXXX treated on Dana-Farber @entity1 Institute consortium protocols.

answer: @entity5


abstract: The optimal management of asparaginase-associated @entity4 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity0 with @entity5 ( @entity5 ) with asparaginase-related @entity6 ( @entity6 ) treated at Dana-Farber @entity1 Institute on clinical trials for newly diagnosed @entity5 between 1991-2008. Of 548 @entity0 , 43 (8%) had @entity6 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity0 . @entity2 occurred in 1  6% of @entity0 . Age was the only significant predictor of @entity6 , with those aged >30years at very high risk ( @entity6 rate 42%). 74% of @entity0 received low molecular weight heparin after @entity6 . Complications of anticoagulation included @entity7 (9%), @entity8 (2%) and, in two adult @entity0 , major @entity3 . Thirty @entity0 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity0 experienced recurrent @entity6 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity0 with @entity6 was 85  6% compared with 88  2% for those without @entity6 (P=0  36). This study confirms that, after @entity6 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity6 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related XXXX in paediatric and adult @entity0 with @entity5 treated on Dana-Farber @entity1 Institute consortium protocols.

answer: @entity4


abstract: The optimal management of asparaginase-associated @entity4 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity0 with @entity5 ( @entity5 ) with asparaginase-related @entity6 ( @entity6 ) treated at Dana-Farber @entity1 Institute on clinical trials for newly diagnosed @entity5 between 1991-2008. Of 548 @entity0 , 43 (8%) had @entity6 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity0 . @entity2 occurred in 1  6% of @entity0 . Age was the only significant predictor of @entity6 , with those aged >30years at very high risk ( @entity6 rate 42%). 74% of @entity0 received low molecular weight heparin after @entity6 . Complications of anticoagulation included @entity7 (9%), @entity8 (2%) and, in two adult @entity0 , major @entity3 . Thirty @entity0 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity0 experienced recurrent @entity6 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity0 with @entity6 was 85  6% compared with 88  2% for those without @entity6 (P=0  36). This study confirms that, after @entity6 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity6 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related @entity4 in paediatric and adult @entity0 with @entity5 treated on Dana-Farber XXXX Institute consortium protocols.

answer: @entity1


abstract: The optimal management of asparaginase-associated @entity4 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity0 with @entity5 ( @entity5 ) with asparaginase-related @entity6 ( @entity6 ) treated at Dana-Farber @entity1 Institute on clinical trials for newly diagnosed @entity5 between 1991-2008. Of 548 @entity0 , 43 (8%) had @entity6 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity0 . @entity2 occurred in 1  6% of @entity0 . Age was the only significant predictor of @entity6 , with those aged >30years at very high risk ( @entity6 rate 42%). 74% of @entity0 received low molecular weight heparin after @entity6 . Complications of anticoagulation included @entity7 (9%), @entity8 (2%) and, in two adult @entity0 , major @entity3 . Thirty @entity0 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity0 experienced recurrent @entity6 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity0 with @entity6 was 85  6% compared with 88  2% for those without @entity6 (P=0  36). This study confirms that, after @entity6 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity6 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related @entity4 in paediatric and adult XXXX with @entity5 treated on Dana-Farber @entity1 Institute consortium protocols.

answer: @entity0


abstract: INTRODUCTION: Few couple-focused interventions have been developed to improve distress and relationship outcomes among @entity0 diagnosed with @entity2 and their partners. AIMS: We examined the effects of a five-session Intimacy-Enhancing Therapy (IET) vs. Usual Care (UC) on the psychological and relationship functioning of @entity0 diagnosed with @entity2 and their partners. Pre-intervention levels of psychological and relationship functioning were evaluated as moderators of intervention effects. METHODS: Seventy-one survivors and their partners completed a baseline survey and were subsequently randomly assigned to receive five sessions of IET or UC (no treatment). Eight weeks after the baseline assessment, a follow-up survey was administered to survivor and partner. MAIN OUTCOME MEASURES: Distress, well-being, relationship satisfaction, relationship intimacy, and communication were investigated as the main outcomes. RESULTS: IET effects were largely moderated by pre-intervention psychosocial and relationship factors. Those survivors who had higher levels of @entity1 concerns at pretreatment had significantly reduced concerns following IET. Similar moderating effects for pre-intervention levels were reported for the effects of IET on self-disclosure, perceived partner disclosure, and perceived partner responsiveness. Among partners beginning the intervention with higher @entity1 , lower marital satisfaction, lower intimacy, and poorer communication, IET improved these outcomes. CONCLUSIONS: IET had a marginally significant main effect upon survivor well-being but was effective among couples with fewer personal and relationship resources. Subsequent research is needed to replicate these findings with a larger sample and a longer follow-up.

title: Intimacy-enhancing psychological intervention for @entity0 diagnosed with XXXX and their partners: a pilot study.

answer: @entity2


abstract: INTRODUCTION: Few couple-focused interventions have been developed to improve distress and relationship outcomes among @entity0 diagnosed with @entity2 and their partners. AIMS: We examined the effects of a five-session Intimacy-Enhancing Therapy (IET) vs. Usual Care (UC) on the psychological and relationship functioning of @entity0 diagnosed with @entity2 and their partners. Pre-intervention levels of psychological and relationship functioning were evaluated as moderators of intervention effects. METHODS: Seventy-one survivors and their partners completed a baseline survey and were subsequently randomly assigned to receive five sessions of IET or UC (no treatment). Eight weeks after the baseline assessment, a follow-up survey was administered to survivor and partner. MAIN OUTCOME MEASURES: Distress, well-being, relationship satisfaction, relationship intimacy, and communication were investigated as the main outcomes. RESULTS: IET effects were largely moderated by pre-intervention psychosocial and relationship factors. Those survivors who had higher levels of @entity1 concerns at pretreatment had significantly reduced concerns following IET. Similar moderating effects for pre-intervention levels were reported for the effects of IET on self-disclosure, perceived partner disclosure, and perceived partner responsiveness. Among partners beginning the intervention with higher @entity1 , lower marital satisfaction, lower intimacy, and poorer communication, IET improved these outcomes. CONCLUSIONS: IET had a marginally significant main effect upon survivor well-being but was effective among couples with fewer personal and relationship resources. Subsequent research is needed to replicate these findings with a larger sample and a longer follow-up.

title: Intimacy-enhancing psychological intervention for XXXX diagnosed with @entity2 and their partners: a pilot study.

answer: @entity0


abstract: This study was aimed to investigate the fundus changes of @entity0 with pregnancy-induced @entity2 syndrome (PIHS) using optical coherence tomography (OCT) technology and @entity1 ( @entity1 ) tests.Ninety-eight @entity0 with PIHS underwent routine eye examinations including vision correction, fundus examination, OCT, and @entity1 tests. The @entity1 test was performed at low, medium, and high frequency, respectively. Moreover, the difference in @entity1 tests between 2 groups was analyzed by independent-samples T test. The Kruskal-Wallis rank sum test and linear regression model were used to detect the correlation of OCT with @entity1 , respectively. Meanwhile Satterthwaite approximate T test was adopted for pairwise comparisons after nonparametric analysis of variance.The OCT test revealed that 56.76% of the examined eyes showed shallow @entity3 in the macula lutea and around the optic disk. The differences in @entity1 at each spatial frequency between the case and control group were statistically significant (P<0.01). Besides, OCT manifestations were associated with @entity1 at each spacial frequency including 1.5, 3, 6, 12, and 18 frequency (P<0.01). And @entity0 with abnormal manifestations of OCT showed lower @entity1 at each spacial frequency than those without abnormal OCT manifestations. What's more the OCT manifestation 1 showed the greatest impact on @entity1 at each spacial frequency.The results showed that abnormal OCT manifestations were correlated with @entity1 in PIHS. OCT and @entity1 tests might be valuable methods in observing fundus changes for PIHS @entity0 .

title: Application of Optical Coherence Tomography and Contrast Sensitivity Test for Observing Fundus Changes of @entity0 With XXXX .

answer: @entity2


abstract: This study was aimed to investigate the fundus changes of @entity0 with pregnancy-induced @entity2 syndrome (PIHS) using optical coherence tomography (OCT) technology and @entity1 ( @entity1 ) tests.Ninety-eight @entity0 with PIHS underwent routine eye examinations including vision correction, fundus examination, OCT, and @entity1 tests. The @entity1 test was performed at low, medium, and high frequency, respectively. Moreover, the difference in @entity1 tests between 2 groups was analyzed by independent-samples T test. The Kruskal-Wallis rank sum test and linear regression model were used to detect the correlation of OCT with @entity1 , respectively. Meanwhile Satterthwaite approximate T test was adopted for pairwise comparisons after nonparametric analysis of variance.The OCT test revealed that 56.76% of the examined eyes showed shallow @entity3 in the macula lutea and around the optic disk. The differences in @entity1 at each spatial frequency between the case and control group were statistically significant (P<0.01). Besides, OCT manifestations were associated with @entity1 at each spacial frequency including 1.5, 3, 6, 12, and 18 frequency (P<0.01). And @entity0 with abnormal manifestations of OCT showed lower @entity1 at each spacial frequency than those without abnormal OCT manifestations. What's more the OCT manifestation 1 showed the greatest impact on @entity1 at each spacial frequency.The results showed that abnormal OCT manifestations were correlated with @entity1 in PIHS. OCT and @entity1 tests might be valuable methods in observing fundus changes for PIHS @entity0 .

title: Application of Optical Coherence Tomography and Contrast Sensitivity Test for Observing Fundus Changes of XXXX With @entity2 .

answer: @entity0


abstract: Streptococci and actinomyces that initiate colonization of the tooth surface frequently coaggregate with each other as well as with other oral bacteria. These observations have led to the hypothesis that interbacterial adhesion influences spatiotemporal development of plaque. To assess the role of such interactions in oral biofilm formation in vivo, antibodies directed against bacterial surface components that mediate coaggregation interactions were used as direct immunofluorescent probes in conjunction with laser confocal microscopy to determine the distribution and spatial arrangement of bacteria within intact @entity0 plaque formed on retrievable enamel chips. In intrageneric coaggregation, streptococci such as @entity2 @entity4 recognize @entity5 ( @entity5 ) borne on other streptococci such as @entity3 34. To define potentially interactive subsets of streptococci in the developing plaque, an antibody against @entity5 (anti- @entity5 ) was used together with an antibody against S. gordonii @entity4 ( @entity4 ). These antibodies reacted primarily with single cells in 4-h-old plaque and with mixed-species microcolonies in 8-h-old plaque. Anti- @entity5 -reactive bacteria frequently formed microcolonies with anti- @entity4 -reactive bacteria and with other bacteria distinguished by general nucleic acid stains. In intergeneric coaggregation between streptococci and actinomyces, type 2 fimbriae of actinomyces recognize @entity5 on the streptococci. Cells reactive with antibody against type 2 fimbriae of Actinomyces naeslundii @entity6 (anti-type-2) were much less frequent than either subset of streptococci. However, bacteria reactive with anti-type-2 were seen in intimate association with anti- @entity5 -reactive cells. These results are the first direct demonstration of coaggregation-mediated interactions during initial plaque accumulation in vivo. Further, these results demonstrate the spatiotemporal development and prevalence of mixed-species communities in @entity1 .

title: Coaggregation-mediated interactions of streptococci and actinomyces detected in initial XXXX dental plaque.

answer: @entity0


abstract: Quantification of programmed and accidental cell death provides useful end-points for the anticancer drug efficacy assessment. Cell death is, however, a stochastic process. Therefore, the opportunity to dynamically quantify individual cellular states is advantageous over the commonly employed static, end-point assays. In this work, we describe the development and application of a microfabricated, dielectrophoretic (DEP) cell immobilization platform for the real-time analysis of @entity1 drug-induced @entity2 . Microelectrode arrays were designed to generate weak electro-thermal vortices that support efficient drug mixing and rapid cell immobilization at the delta-shape regions of strong electric field formed between the opposite microelectrodes. We applied this technology to the dynamic analysis of @entity3 cells that represent a particular challenge for real-time imaging due to their dislodgement during image acquisition. The present study was designed to provide a comprehensive mechanistic rationale for accelerated cell-based assays on DEP chips using real-time labeling with cell permeability markers. In this context, we provide data on the complex behavior of viable vs dying cells in the DEP fields and probe the effects of DEP fields upon cell responses to anticancer drugs and overall bioassay performance. Results indicate that simple DEP cell immobilization technology can be readily applied for the dynamic analysis of investigational drugs in @entity1 cells. This ability is of particular importance in studying the outcome of @entity0 derived @entity1 cells, when exposed to therapeutic drugs, as these cells are often rare and difficult to collect, purify and immobilize.

title: Dynamic analysis of drug-induced XXXX using chip-based dielectrophoretic cell immobilization technology.

answer: @entity2


abstract: OBJECTIVE: To describe the radiographic cervical spine changes in @entity1 @entity0 . METHODS: Forty-nine @entity0 (37 females and 12 males) diagnosed with @entity1 at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia, between June 1998 and June 2000, were studied for their radiographic cervical spine changes. Their mean age at disease onset was 41.4 +/- 13.4 years (range of 18-73) and mean duration of the disease was 9.1 +/- 6.28 years (range of 2-34). Their demographic data including rheumatoid factor status was obtained. Standard conventional radiographs of cervical spine were obtained to study the cervical spine changes. RESULTS: Cervical spine radiographic changes were found in 34 @entity0 (27 females and 7 males), 10 had subluxation (7 with atlanto-axial subluxation, 2 with sub-axial subluxation, and one with lateral subluxation). No vertical @entity2 was seen. Erosion of odontoid process was seen in one @entity0 . All were rheumatoid seropositive. CONCLUSION: Cervical spine changes in @entity0 with @entity1 are common, in particular subluxation in the upper cervical spine. Our study showed somewhat lesser prevalence of these changes. These were clinically correlated with disease duration, female sex, and rheumatoid factor, but were not statistically significant.

title: XXXX . Radiological changes in the cervical spine.

answer: @entity1


abstract: DNA aneuploidy is a biological marker of the oncogenic potential of @entity8 . The accumulation of genetic alterations of @entity0 -related genes is also essential for @entity1 . However, it is unclear whether there is any relationship between these genetic alterations and the DNA ploidy of @entity0 cells in the progression of @entity8 and early @entity1 . Here we have studied the DNA ploidy state and genetic alterations occurring in @entity1 using the crypt isolation technique. Crypts isolated from a total of 106 @entity1 ( @entity4 , 93; early @entity3 , 13) were examined using a combination of flow cytometric analysis of DNA content, polymerase chain reaction-microsatellite assay, and single-strand conformation polymorphism assay for evidence of chromosomal allelic imbalance (AI; 17p; 5q; 18q) or @entity5 gene mutation. In addition, we examined @entity2 ( @entity2 ) with BAT 26 primer sets. DNA multiploidy was infrequently detected in @entity8 (15.1%), in contrast to early @entity3 (46.2%). There was a significant difference in the incidence of AI of chromosome 18q between diploid @entity4 and @entity7 populations of multiploid @entity4 (18.1% vs 57.1%, p = 0.0043). Mutation of @entity5 was also found more frequently in @entity7 populations of early multiploid @entity1 than in early diploid @entity1 (66.7% vs 0%, p = 0.021). @entity2 was found in only 2 of 93 @entity4 , with no @entity2 detected in early @entity1 . The two @entity2 -positive @entity4 were diploid. We subdivided multiploid @entity4 into two groups: those with a low or a high @entity6 ( @entity6 ). The incidence of genetic alterations of high- @entity6 @entity4 did not differ from those of low- @entity6 @entity4 . Allelic imbalance involving loci on chromosome 18q and mutations of @entity5 seems to be associated with the progression of diploidy to multiploidy in @entity1 . On the other hand, @entity2 may be associated with the development of some @entity0 . In addition, the incidence of genetic alterations in the @entity8 that we examined appears to be independent of the @entity0 's @entity6 .

title: Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of XXXX and early @entity1 .

answer: @entity8


abstract: DNA aneuploidy is a biological marker of the oncogenic potential of @entity8 . The accumulation of genetic alterations of @entity0 -related genes is also essential for @entity1 . However, it is unclear whether there is any relationship between these genetic alterations and the DNA ploidy of @entity0 cells in the progression of @entity8 and early @entity1 . Here we have studied the DNA ploidy state and genetic alterations occurring in @entity1 using the crypt isolation technique. Crypts isolated from a total of 106 @entity1 ( @entity4 , 93; early @entity3 , 13) were examined using a combination of flow cytometric analysis of DNA content, polymerase chain reaction-microsatellite assay, and single-strand conformation polymorphism assay for evidence of chromosomal allelic imbalance (AI; 17p; 5q; 18q) or @entity5 gene mutation. In addition, we examined @entity2 ( @entity2 ) with BAT 26 primer sets. DNA multiploidy was infrequently detected in @entity8 (15.1%), in contrast to early @entity3 (46.2%). There was a significant difference in the incidence of AI of chromosome 18q between diploid @entity4 and @entity7 populations of multiploid @entity4 (18.1% vs 57.1%, p = 0.0043). Mutation of @entity5 was also found more frequently in @entity7 populations of early multiploid @entity1 than in early diploid @entity1 (66.7% vs 0%, p = 0.021). @entity2 was found in only 2 of 93 @entity4 , with no @entity2 detected in early @entity1 . The two @entity2 -positive @entity4 were diploid. We subdivided multiploid @entity4 into two groups: those with a low or a high @entity6 ( @entity6 ). The incidence of genetic alterations of high- @entity6 @entity4 did not differ from those of low- @entity6 @entity4 . Allelic imbalance involving loci on chromosome 18q and mutations of @entity5 seems to be associated with the progression of diploidy to multiploidy in @entity1 . On the other hand, @entity2 may be associated with the development of some @entity0 . In addition, the incidence of genetic alterations in the @entity8 that we examined appears to be independent of the @entity0 's @entity6 .

title: Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of @entity8 and early XXXX .

answer: @entity1


abstract: The aim of this study was to estabilish whether subtle changes in regional cerebral blood flow ( @entity4 ) can be detected in @entity0 with mild @entity2 ( @entity2 ) over a period as short as three months. Aprospective evaluation of @entity4 changes with HMPAO SPECT at baseline and after 3 and 6 months was carried out. Standard clinical @entity3 tests were performed in parallel. The study enrolled 13 @entity0 with mild probable @entity2 from an outpatient memory clinic. SPECT data collected at baseline and after three months were compared using Statistical Parametric Mapping (SPM). Significant clusters of @entity4 decrement in the medial part of the temporal lobe in both hemispheres, in the orbital part of the right frontal lobe and in the inferior part of the right parietal lobe were observed. No significant differences were found using a region of interest (ROI) analysis. After six months SPM analysis showed larger clusters of significant decrement in the same areas. ROI analysis was now sensitive to the @entity4 changes and significant differences were shown in all brain regions except the temporal lobes. SPM analysis of SPECT data can detect significant changes in @entity4 in mild @entity2 over a short time interval. This method might be of potential advantage for the early diagnosis of @entity2 and for its differentiation from stable @entity1 .

title: Short-term longitudinal evaluation of cerebral blood flow in mild XXXX .

answer: @entity2


abstract: Twenty-one @entity0 with @entity2 diagnosed between 1973 and 1983 were analyzed retrospectively. Median age at diagnosis was eleven months (1 week to 153 months). @entity1 was above the diaphragm in 67% and below the diaphragm in 33%. All @entity0 underwent surgical resection and pathologic diagnosis was @entity4 in 76% and @entity5 in 24%. Regional lymph nodes were positive in three of eleven @entity0 sampled. Sixty-seven percent had gross @entity3 , and thirty-three percent had microscopic @entity3 . Seventeen @entity0 received postoperative irradiation and none has relapsed (median follow-up 57 months). Four @entity0 received surgery alone (median follow-up 24 months); one local relapse occurred in this group and was subsequently treated with irradiation. All @entity0 are alive and disease free, with a median length of follow-up of 55 months. Radiation dosage was 1000-1800 rad in @entity0 less than 12 months of age, and 1800-3000 rad in those greater than 12 months of age at diagnosis. The high disease-free survival rate in both groups of @entity0 , but especially in the group receiving adjuvant irradiation, emphasizes the need for a controlled, prospective study to determine which @entity2 @entity0 , if any, would be benefitted by postoperative irradiation.

title: XXXX --does adjuvant irradiation contribute to cure?

answer: @entity2


abstract: DNA repair gene polymorphisms have been implicated as susceptibility factors in @entity1 development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. @entity10 polymorphism in the DNA repair gene @entity8 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of @entity1 development. Two hundred thirty-seven @entity6 ( @entity6 ) were included in a study to investigate the role of the @entity8 194Trp, 280His, and 399Gln polymorphisms on @entity5 gene mutation. PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the conserved regions of the @entity5 gene (exons 5-9). The @entity8 genotype was determined by PCR-RFLP. Nineteen (8.02%) of the 237 @entity6 had a @entity7 / @entity7 genotype. One hundred six (43.88%) of the 237 @entity6 showed @entity5 gene mutations at exons 5-9. The OSCC @entity0 with a @entity7 / @entity7 genotype exhibited a significantly higher frequency of @entity5 mutation than those with an @entity3 / @entity7 and an Arg/Arg genotype. After adjustment for age, cigarette smoking, areca quid chewing, and @entity2 drinking, the @entity7 / @entity7 genotype still showed an independent association with the frequency of @entity5 mutation (odd ratio, 4.50; 95% confidence interval, 1.52-13.36). The findings support the hypothesis that @entity8 @entity9 @entity4 change may alter the phenotype of the @entity8 protein, resulting in a DNA repair deficiency. This study also suggests an important role for the @entity8 399Gln polymorphism in @entity5 gene mutation in Taiwanese @entity6 .

title: The @entity8 399Gln polymorphism and the frequency of @entity5 mutations in Taiwanese XXXX .

answer: @entity6


abstract: DNA repair gene polymorphisms have been implicated as susceptibility factors in @entity1 development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. @entity10 polymorphism in the DNA repair gene @entity8 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of @entity1 development. Two hundred thirty-seven @entity6 ( @entity6 ) were included in a study to investigate the role of the @entity8 194Trp, 280His, and 399Gln polymorphisms on @entity5 gene mutation. PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the conserved regions of the @entity5 gene (exons 5-9). The @entity8 genotype was determined by PCR-RFLP. Nineteen (8.02%) of the 237 @entity6 had a @entity7 / @entity7 genotype. One hundred six (43.88%) of the 237 @entity6 showed @entity5 gene mutations at exons 5-9. The OSCC @entity0 with a @entity7 / @entity7 genotype exhibited a significantly higher frequency of @entity5 mutation than those with an @entity3 / @entity7 and an Arg/Arg genotype. After adjustment for age, cigarette smoking, areca quid chewing, and @entity2 drinking, the @entity7 / @entity7 genotype still showed an independent association with the frequency of @entity5 mutation (odd ratio, 4.50; 95% confidence interval, 1.52-13.36). The findings support the hypothesis that @entity8 @entity9 @entity4 change may alter the phenotype of the @entity8 protein, resulting in a DNA repair deficiency. This study also suggests an important role for the @entity8 399Gln polymorphism in @entity5 gene mutation in Taiwanese @entity6 .

title: The @entity8 399Gln polymorphism and the frequency of XXXX mutations in Taiwanese @entity6 .

answer: @entity5


abstract: DNA repair gene polymorphisms have been implicated as susceptibility factors in @entity1 development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. @entity10 polymorphism in the DNA repair gene @entity8 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of @entity1 development. Two hundred thirty-seven @entity6 ( @entity6 ) were included in a study to investigate the role of the @entity8 194Trp, 280His, and 399Gln polymorphisms on @entity5 gene mutation. PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the conserved regions of the @entity5 gene (exons 5-9). The @entity8 genotype was determined by PCR-RFLP. Nineteen (8.02%) of the 237 @entity6 had a @entity7 / @entity7 genotype. One hundred six (43.88%) of the 237 @entity6 showed @entity5 gene mutations at exons 5-9. The OSCC @entity0 with a @entity7 / @entity7 genotype exhibited a significantly higher frequency of @entity5 mutation than those with an @entity3 / @entity7 and an Arg/Arg genotype. After adjustment for age, cigarette smoking, areca quid chewing, and @entity2 drinking, the @entity7 / @entity7 genotype still showed an independent association with the frequency of @entity5 mutation (odd ratio, 4.50; 95% confidence interval, 1.52-13.36). The findings support the hypothesis that @entity8 @entity9 @entity4 change may alter the phenotype of the @entity8 protein, resulting in a DNA repair deficiency. This study also suggests an important role for the @entity8 399Gln polymorphism in @entity5 gene mutation in Taiwanese @entity6 .

title: The XXXX 399Gln polymorphism and the frequency of @entity5 mutations in Taiwanese @entity6 .

answer: @entity8


abstract: OBJECTIVE: To present an institutional experience with stent placement in the arterial duct combined with bilateral banding of the pulmonary artery branches as a basis for various surgical strategies in newborns with hypoplastic left @entity1 . DESIGN: Observational study. SETTING: Paediatric heart centre in a university hospital. @entity0 : 20 newborns with various forms of left @entity1 and duct dependent systemic blood flow. INTERVENTIONS: @entity0 underwent percutaneous ductal stenting and surgical bilateral pulmonary artery banding. @entity2 was performed as required, in one premature baby by the transhepatic approach. MAIN OUTCOME MEASURES: Survival; numbers of and reasons for palliative and corrective cardiac surgery. RESULTS: One @entity0 died immediately after percutaneous ductal stenting. One @entity0 died in connection with the surgical approach of bilateral pulmonary banding. Stent and ductal patency were achieved for up to 331 days. Two @entity0 underwent heart transplantation and two @entity0 died on the waiting list. Ten @entity0 had a palliative one stage procedure with reconstruction of the aortic arch and bidirectional cavopulmonary connection at the age of 3.5-6 months. There was one death. One @entity0 is still awaiting this approach. Two @entity0 received biventricular repair. In one, biventricular repair will soon be provided. CONCLUSIONS: Stenting the arterial duct combined with bilateral pulmonary artery banding in newborns with @entity3 or multiple left @entity1 allows a broad variation of surgical strategies depending on morphological findings, postnatal clinical conditions, and potential ventricular growth.

title: Stenting of the ductus arteriosus and banding of the pulmonary arteries: basis for various surgical strategies in newborns with multiple left XXXX .

answer: @entity1


abstract: This study was performed to investigate whether measurement of @entity4 ( @entity3 ), a marker for @entity2 production, before and after allogeneic bone marrow transplantation (BMT) with @entity1 ( @entity1 ) conditioning was of prognostic value. @entity3 levels were monitored in 23 consecutive @entity0 who received @entity1 as conditioning for BMT, and were compared with the outcome. @entity3 became positive during the aplastic phase after BMT in 12 @entity0 . In nine of these 12 @entity0 , @entity3 level decreased during the recovery phase. Eight of the nine @entity0 survived, one dying after relapse. In three other @entity0 , the @entity3 level continued to increase even during the recovery phase and they died of severe complications. @entity3 became positive on day 0 of BMT and during the leukocyte recovery phase after BMT in two and seven of the 23 @entity0 , respectively. Subsequently, all @entity0 died of severe complications. The two @entity0 who were negative for @entity3 both before and after BMT survived without complications. These results suggest that monitoring @entity3 from early after BMT may be useful for predicting outcome and that it may be a useful prognostic marker.

title: Prognostic value of XXXX in @entity0 undergoing allogeneic bone marrow transplantation after conditioning with @entity1 .

answer: @entity4


abstract: This study was performed to investigate whether measurement of @entity4 ( @entity3 ), a marker for @entity2 production, before and after allogeneic bone marrow transplantation (BMT) with @entity1 ( @entity1 ) conditioning was of prognostic value. @entity3 levels were monitored in 23 consecutive @entity0 who received @entity1 as conditioning for BMT, and were compared with the outcome. @entity3 became positive during the aplastic phase after BMT in 12 @entity0 . In nine of these 12 @entity0 , @entity3 level decreased during the recovery phase. Eight of the nine @entity0 survived, one dying after relapse. In three other @entity0 , the @entity3 level continued to increase even during the recovery phase and they died of severe complications. @entity3 became positive on day 0 of BMT and during the leukocyte recovery phase after BMT in two and seven of the 23 @entity0 , respectively. Subsequently, all @entity0 died of severe complications. The two @entity0 who were negative for @entity3 both before and after BMT survived without complications. These results suggest that monitoring @entity3 from early after BMT may be useful for predicting outcome and that it may be a useful prognostic marker.

title: Prognostic value of @entity4 in @entity0 undergoing allogeneic bone marrow transplantation after conditioning with XXXX .

answer: @entity1


abstract: This study was performed to investigate whether measurement of @entity4 ( @entity3 ), a marker for @entity2 production, before and after allogeneic bone marrow transplantation (BMT) with @entity1 ( @entity1 ) conditioning was of prognostic value. @entity3 levels were monitored in 23 consecutive @entity0 who received @entity1 as conditioning for BMT, and were compared with the outcome. @entity3 became positive during the aplastic phase after BMT in 12 @entity0 . In nine of these 12 @entity0 , @entity3 level decreased during the recovery phase. Eight of the nine @entity0 survived, one dying after relapse. In three other @entity0 , the @entity3 level continued to increase even during the recovery phase and they died of severe complications. @entity3 became positive on day 0 of BMT and during the leukocyte recovery phase after BMT in two and seven of the 23 @entity0 , respectively. Subsequently, all @entity0 died of severe complications. The two @entity0 who were negative for @entity3 both before and after BMT survived without complications. These results suggest that monitoring @entity3 from early after BMT may be useful for predicting outcome and that it may be a useful prognostic marker.

title: Prognostic value of @entity4 in XXXX undergoing allogeneic bone marrow transplantation after conditioning with @entity1 .

answer: @entity0


abstract: OBJECTIVE: Vulvar and @entity1 are @entity4 with an incidence rate that increases with age. At present, epidemiological data are rather scarce. This review article provides an epidemiologic overview of these diseases, focussing on recent German data. METHODS: This review article summarizes the information currently available in order to offer an epidemiologic overview. RESULTS: The statistic incidence of @entity2 has been calculated between 2 and 7 cases per 100,000 @entity0 , and that of @entity2 0.6-1.0 cases per 100,000 @entity0 . These incidence rates, especially concerning @entity5 , have increased heavily since the 1970s. The mean age of @entity1 affection is 72 years, and 74 years for @entity2 . In the case of @entity0 below the age of 50, @entity1 tends to be HPV-associated which implies a coincidence of about 20% for cervical and @entity1 . Various pathological mechanisms are the cause for @entity0 above the age of 50. CONCLUSIONS: Due to a change in sexual behavior and an increased rate of @entity3 among younger @entity0 , increased incidence of both diseases has to be expected. The age-standardized mortality rate of @entity2 in Europe is stated at 0.7/100,000 @entity0 , and that of @entity2 at 0.4/100.000 @entity0 . To what extent the HPV-vaccination affects incidence and mortality rates is continually being observed.

title: XXXX in Germany.

answer: @entity1


abstract: AIM: @entity1 ( @entity1 ) is the most common cause of unsuccessful pregnancy after assisted reproductive techniques. The @entity0 protein @entity2 ( @entity2 ) codon 72 polymorphism (G-C transversion) has been explored in susceptibility to @entity1 , but inconclusive results have been reported. The aim of this article is to estimate the associations between the @entity2 codon 72 polymorphism and the risk of @entity1 . MATERIALS AND METHODS: A comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for CC + GC versus GG, CC versus GC + GG, CC versus GG, GC versus GG genotypes, and C versus G allele, were estimated. Publication bias was explored. Statistical analyses were performed using RevMan 5.2 and Stata 11.0 software. RESULTS: A total of five case-control studies in five articles with 417 @entity1 cases and 325 controls were included. An overall random effect OR of 1.20 (95% CI, 0.66-2.19; P = 0.55) in the dominant model (CC + GC vs GG) was found. The results suggested that a lack of increased or decreased risks were found in individuals who carried the CC homozygote and heterozygote GC, in comparison with the homozygote GG. However, in subgroup analysis by ethnicity, a significantly increased risk was observed among Latin Americans in the dominant model (OR, 1.56; 95% CI, 1.04-2.33; P = 0.03). CONCLUSIONS: This meta-analysis shows that the @entity2 codon 72 polymorphism is not associated with @entity1 risk in the overall population; however, associations were found in the Latin American population.

title: Associations between the codon 72 polymorphism of the XXXX gene and the risk of recurrent implantation failure.

answer: @entity2


abstract: STUDY DESIGN: Systematic literature review OBJECTIVE.: 1) To identify @entity0 reported and clinician based outcome measures most frequently used to evaluate the function and health of spine @entity1 @entity0 , 2) to identify and quantify the concepts of these measures using the ICF as reference, and 3) to describe their clinimetric properties. SUMMARY OF BACKGROUND DATA: There is a real need for a disease specific outcome instrument to measure the effect size of various treatment options in a variety of traumatic spinal column injuries. METHODS: A systematic literature search was conducted in several databases. From the included studies, outcome measures were extracted. The items and underlying concepts of the identified outcome measures were specified and linked to the ICF categories.Finally, as far as available in literature, the clinimetric properties of the obtained measures were analyzed. RESULTS: Out of 5117 screened references, 245 were included, and 17 different frequently used outcome measures were identified.Meaningful concepts of the items and response options of the retrieved outcome measures were linked to a total of 105 different ICF categories, aggregated to 57 first- or second-level categories. The categories were linked to the components activities and participation (n=31), body functions (n=17), environmental factors (n=8), and body structures (n=1).Overall, there is only limited evidence on the measurement properties, except for some disease specific questionnaires, such as ODI, RMDQ, @entity2 , and CSOQ. CONCLUSIONS: The current systematic literature review revealed great diversity in the use and content of outcome measures to evaluate the functioning and health of spine @entity1 @entity0 , with 17 different outcome measures linked to 57 unique ICF categories.This study creates an evidence base for a consensus meeting during which a core set of ICF categories for outcome measurement in spine @entity1 will be decided. LEVEL OF EVIDENCE: 2.

title: Towards the Development of a Universal Outcome Instrument for Spine @entity1 - A Systematic Review and Content Comparison of Outcome Measures used in Spine XXXX Research Using the ICF as Reference.

answer: @entity1


abstract: STUDY DESIGN: Systematic literature review OBJECTIVE.: 1) To identify @entity0 reported and clinician based outcome measures most frequently used to evaluate the function and health of spine @entity1 @entity0 , 2) to identify and quantify the concepts of these measures using the ICF as reference, and 3) to describe their clinimetric properties. SUMMARY OF BACKGROUND DATA: There is a real need for a disease specific outcome instrument to measure the effect size of various treatment options in a variety of traumatic spinal column injuries. METHODS: A systematic literature search was conducted in several databases. From the included studies, outcome measures were extracted. The items and underlying concepts of the identified outcome measures were specified and linked to the ICF categories.Finally, as far as available in literature, the clinimetric properties of the obtained measures were analyzed. RESULTS: Out of 5117 screened references, 245 were included, and 17 different frequently used outcome measures were identified.Meaningful concepts of the items and response options of the retrieved outcome measures were linked to a total of 105 different ICF categories, aggregated to 57 first- or second-level categories. The categories were linked to the components activities and participation (n=31), body functions (n=17), environmental factors (n=8), and body structures (n=1).Overall, there is only limited evidence on the measurement properties, except for some disease specific questionnaires, such as ODI, RMDQ, @entity2 , and CSOQ. CONCLUSIONS: The current systematic literature review revealed great diversity in the use and content of outcome measures to evaluate the functioning and health of spine @entity1 @entity0 , with 17 different outcome measures linked to 57 unique ICF categories.This study creates an evidence base for a consensus meeting during which a core set of ICF categories for outcome measurement in spine @entity1 will be decided. LEVEL OF EVIDENCE: 2.

title: Towards the Development of a Universal Outcome Instrument for Spine XXXX - A Systematic Review and Content Comparison of Outcome Measures used in Spine @entity1 Research Using the ICF as Reference.

answer: @entity1


abstract: STUDY DESIGN: A consecutive retrospective cohort study from 2008 to 2013 at a single tertiary-care institution was conducted. OBJECTIVE: Characterize recovery from @entity2 after surgical for @entity4 , and identify incidence of postoperative adverse events. SUMMARY OF BACKGROUND DATA: A minority of @entity0 with @entity4 require surgery. While prior studies have characterized outcomes after medical management, the morbidity after surgery is poorly defined. METHODS: The primary outcome was change from baseline in a Modified McCormick Scale (MMS, 1-5 scale), while secondary outcomes included reoperation and change in self-reported @entity3 Visual Analog Scale (VAS, 0-10 scale).MMS and VAS were collected throughout the postoperative course as surrogates for neurologic function and degree of @entity3 . Intraoperative, short-term postoperative (<30 days), and long-term neurologic complications were recorded. New-onset @entity2 in the postoperative period were considered neurologic complications. RESULTS: Fifty @entity0 were included; a majority (52%) presented with a @entity2 . The median length of follow-up was 18 months. A statistically significant improvement in MMS was observed by 12 months postoperatively, while an improvement in VAS was observed by 3 months. The mean improvement in MMS at last follow-up was 0.35, while the mean improvement in VAS was 3.40. One quarter of @entity0 required reoperation. At 24 months postoperatively, 10% died, 26% underwent reoperation, 42% experienced a @entity1 , and 60% experienced at least one of these three adverse events. CONCLUSIONS: This is the first study to investigate neurologic complications, reoperation, and @entity3 in a longitudinal manner following surgery for VO. We observed statistically significant improvements in MMS and VAS in the postoperative period. Despite these improvements, the 24-month incidence of overall adverse events was 60%. @entity0 and clinicians should be aware of the clinical improvement but high incidence of adverse events following surgical management of VO. LEVEL OF EVIDENCE: 4.

title: Neurologic Complications, Reoperation, and Clinical Outcomes following Surgery for XXXX .

answer: @entity4


abstract: Five ruminally cannulated lactating Holstein @entity0 , fitted with permanent indwelling catheters in the mesenteric vein, hepatic vein, portal vein, and an artery were used to study intestinal absorption and net recycling of inorganic @entity1 (P(i)) to the gastrointestinal tract. Treatments were low P (LP; 2.4 g of P/kg of @entity4 ) and @entity2 ( @entity2 ; 3.4 g of P/kg of @entity4 ). The dietary total P (tP) concentrations were obtained by replacing 0.50% @entity5 in the LP diet with 0.50% @entity6 in the @entity2 diet. Diets were fed for 14 d and @entity0 were sampled on d 14 in each period. @entity0 were fed restrictively, resulting in equal dry matter intakes as well as milk, fat, and protein yields between treatments. Net P(i) recycling (primarily salivary) was estimated as the difference between net portal plasma flux (net absorption of P(i)) and apparently digested tP (feed - fecal tP difference). @entity3 intake, apparently digested tP, and fecal tP excretion decreased with LP. An effect of decreased tP intake on net portal plasma flux of P(i) could not be detected. However, despite numerically minute net fluxes across the liver, the net splanchnic flux of P(i) was less in LP compared with that in @entity2 . Though arterial plasma P(i) concentration decreased, net P(i) recycling was not decreased when tP intake was decreased, and recycling of P(i) was maintained at the expense of deposition of P(i) in bones. Data are not consistent with salivary P(i) secretion being the primary regulator of P(i) homeostasis at low tP intakes. On the contrary, maintaining salivary P(i) recycling at low tP intakes indicates that rumen function was prioritized at the expense of bone P reserves.

title: Effect of decreasing dietary @entity3 supply on net recycling of inorganic XXXX in lactating dairy @entity0 .

answer: @entity1


abstract: Five ruminally cannulated lactating Holstein @entity0 , fitted with permanent indwelling catheters in the mesenteric vein, hepatic vein, portal vein, and an artery were used to study intestinal absorption and net recycling of inorganic @entity1 (P(i)) to the gastrointestinal tract. Treatments were low P (LP; 2.4 g of P/kg of @entity4 ) and @entity2 ( @entity2 ; 3.4 g of P/kg of @entity4 ). The dietary total P (tP) concentrations were obtained by replacing 0.50% @entity5 in the LP diet with 0.50% @entity6 in the @entity2 diet. Diets were fed for 14 d and @entity0 were sampled on d 14 in each period. @entity0 were fed restrictively, resulting in equal dry matter intakes as well as milk, fat, and protein yields between treatments. Net P(i) recycling (primarily salivary) was estimated as the difference between net portal plasma flux (net absorption of P(i)) and apparently digested tP (feed - fecal tP difference). @entity3 intake, apparently digested tP, and fecal tP excretion decreased with LP. An effect of decreased tP intake on net portal plasma flux of P(i) could not be detected. However, despite numerically minute net fluxes across the liver, the net splanchnic flux of P(i) was less in LP compared with that in @entity2 . Though arterial plasma P(i) concentration decreased, net P(i) recycling was not decreased when tP intake was decreased, and recycling of P(i) was maintained at the expense of deposition of P(i) in bones. Data are not consistent with salivary P(i) secretion being the primary regulator of P(i) homeostasis at low tP intakes. On the contrary, maintaining salivary P(i) recycling at low tP intakes indicates that rumen function was prioritized at the expense of bone P reserves.

title: Effect of decreasing dietary XXXX supply on net recycling of inorganic @entity1 in lactating dairy @entity0 .

answer: @entity3


abstract: Five ruminally cannulated lactating Holstein @entity0 , fitted with permanent indwelling catheters in the mesenteric vein, hepatic vein, portal vein, and an artery were used to study intestinal absorption and net recycling of inorganic @entity1 (P(i)) to the gastrointestinal tract. Treatments were low P (LP; 2.4 g of P/kg of @entity4 ) and @entity2 ( @entity2 ; 3.4 g of P/kg of @entity4 ). The dietary total P (tP) concentrations were obtained by replacing 0.50% @entity5 in the LP diet with 0.50% @entity6 in the @entity2 diet. Diets were fed for 14 d and @entity0 were sampled on d 14 in each period. @entity0 were fed restrictively, resulting in equal dry matter intakes as well as milk, fat, and protein yields between treatments. Net P(i) recycling (primarily salivary) was estimated as the difference between net portal plasma flux (net absorption of P(i)) and apparently digested tP (feed - fecal tP difference). @entity3 intake, apparently digested tP, and fecal tP excretion decreased with LP. An effect of decreased tP intake on net portal plasma flux of P(i) could not be detected. However, despite numerically minute net fluxes across the liver, the net splanchnic flux of P(i) was less in LP compared with that in @entity2 . Though arterial plasma P(i) concentration decreased, net P(i) recycling was not decreased when tP intake was decreased, and recycling of P(i) was maintained at the expense of deposition of P(i) in bones. Data are not consistent with salivary P(i) secretion being the primary regulator of P(i) homeostasis at low tP intakes. On the contrary, maintaining salivary P(i) recycling at low tP intakes indicates that rumen function was prioritized at the expense of bone P reserves.

title: Effect of decreasing dietary @entity3 supply on net recycling of inorganic @entity1 in lactating dairy XXXX .

answer: @entity0


abstract: OBJECTIVE: @entity1 is one of the most common debilitating @entity3 conditions in either active or retired military personnel with mild @entity2 (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related @entity1 (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week @entity1 and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 @entity0 and 3 @entity0 with average year-old    SD at 14.3    12.6) subjects' data were analyzed. A two-factor (visit * treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily @entity1 decreasing from 5.7    1.9 to 2.2    2.7 and 4.6    1.3 to 3.5    2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent @entity1 intensity than the SHAM group (56.3    48.2% vs.15.4    43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% @entity1 intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating @entity1 exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.

title: Repetitive Transcranial Magnetic Stimulation in Managing Mild XXXX .

answer: @entity2


abstract: BACKGROUND: We investigated whether @entity3 -based immunosuppression improves outcomes in liver transplantation (LTx) candidates with @entity1 ( @entity1 ). METHODS: In a prospective-randomized open-label international trial, 525 LTx recipients with @entity1 initially receiving @entity0 target of @entity3 inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation into a group on @entity0 target of @entity3 inhibitor-free immunosuppression (group A: 264 @entity0 ) or a group incorporating @entity3 (group B: 261). The primary endpoint was @entity2 ( @entity2 ); intention-to-treat (ITT) analysis was conducted after 8 years. @entity2 ( @entity2 ) was a secondary endpoint. RESULTS: Recurrence-free survival was 64.5% in group A and 70.2% in group B at study end, this difference was not significant (P = 0.28; hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62; 1.15). In a planned analysis of @entity2 rates at yearly intervals, group B showed better outcomes 3 years after transplantation (HR, 0.7; 95% CI, 0.48-1.00). Similarly, @entity2 (P = 0.21; HR, 0.81; 95% CI, 0.58-1.13) was not statistically better in group B at study end, but yearly analyses showed improvement out to 5 years (HR, 0.7; 95% CI, 0.49-1.00). Interestingly, subgroup (Milan Criteria-based) analyses revealed that low-risk, rather than high-risk, @entity0 benefited most from @entity3 ; furthermore, younger recipients (age  <=60) also benefited, as well @entity3 monotherapy @entity0 . Serious adverse event numbers were alike in groups A (860) and B (874). CONCLUSIONS: @entity3 in LTx recipients with @entity1 does not improve long-term @entity2 beyond 5 years. However, a @entity2 and @entity2 benefit is evident in the first 3 to 5 years, especially in low-risk @entity0 . This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with @entity1 .

title: XXXX Use in Liver Transplant Recipients With @entity1 : A Randomized, Multicenter, Open-Label Phase 3 Trial.

answer: @entity3


abstract: BACKGROUND: We investigated whether @entity3 -based immunosuppression improves outcomes in liver transplantation (LTx) candidates with @entity1 ( @entity1 ). METHODS: In a prospective-randomized open-label international trial, 525 LTx recipients with @entity1 initially receiving @entity0 target of @entity3 inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation into a group on @entity0 target of @entity3 inhibitor-free immunosuppression (group A: 264 @entity0 ) or a group incorporating @entity3 (group B: 261). The primary endpoint was @entity2 ( @entity2 ); intention-to-treat (ITT) analysis was conducted after 8 years. @entity2 ( @entity2 ) was a secondary endpoint. RESULTS: Recurrence-free survival was 64.5% in group A and 70.2% in group B at study end, this difference was not significant (P = 0.28; hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62; 1.15). In a planned analysis of @entity2 rates at yearly intervals, group B showed better outcomes 3 years after transplantation (HR, 0.7; 95% CI, 0.48-1.00). Similarly, @entity2 (P = 0.21; HR, 0.81; 95% CI, 0.58-1.13) was not statistically better in group B at study end, but yearly analyses showed improvement out to 5 years (HR, 0.7; 95% CI, 0.49-1.00). Interestingly, subgroup (Milan Criteria-based) analyses revealed that low-risk, rather than high-risk, @entity0 benefited most from @entity3 ; furthermore, younger recipients (age  <=60) also benefited, as well @entity3 monotherapy @entity0 . Serious adverse event numbers were alike in groups A (860) and B (874). CONCLUSIONS: @entity3 in LTx recipients with @entity1 does not improve long-term @entity2 beyond 5 years. However, a @entity2 and @entity2 benefit is evident in the first 3 to 5 years, especially in low-risk @entity0 . This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with @entity1 .

title: @entity3 Use in Liver Transplant Recipients With XXXX : A Randomized, Multicenter, Open-Label Phase 3 Trial.

answer: @entity1


abstract: OBJECTIVE: To report our experience in the assessment of @entity2 with contrast-coded sonography and a second-generation contrast medium. METHODS: From January to May 2002, 120 @entity0 were studied with sonography for suspected @entity2 . Twenty-five were selected for further imaging because of sonographic findings positive for @entity2 , findings positive for peritoneal fluid only, indeterminate findings, and negative findings with high clinical or laboratory suspicion. These @entity0 underwent contrast-enhanced harmonic sonography and contrast-enhanced helical computed tomography. RESULTS: Among the 25 @entity0 studied, 6 had no spleen trauma at initial and follow-up evaluation. One @entity0 had a hypoperfused spleen without parenchymal damage, and 18 had @entity2 ; these 19 @entity0 were considered positive. @entity5 was identified by sonography, contrast-enhanced sonography, and contrast-enhanced computed tomography in 74% of the 19 positive cases. @entity4 were recognized in 58% of the cases by computed tomography and in 42% by baseline and enhanced sonography. @entity3 were found in 11% of cases by contrast-enhanced sonography and computed tomography; none was found by unenhanced sonography. Parenchymal traumatic lesions were identified in 12 of 18 @entity0 with @entity2 by unenhanced sonography, in 17 cases by contrast-enhanced sonography, and in all 18 cases by contrast-enhanced computed tomography. A minimal @entity1 was found in the single @entity0 with a false-negative contrast-enhanced sonographic finding. Contrast-enhanced sonography correlated appreciably better than unenhanced sonography in detecting injuries and in estimating their extent. Findings undetectable on unenhanced sonography were also noted: splenic hypoperfusion in 11% of positive cases on both contrast-enhanced sonography and contrast-enhanced computed tomography, contrast medium pooling in 21% of cases on both contrast-enhanced sonography and computed tomography, and contrast extravasation in 11% of cases on computed tomography and 5% on contrast-enhanced sonography. CONCLUSIONS: Contrast-enhanced sonography is a promising tool in the assessment of @entity2 . In institutions where sonography is used as the initial procedure, this technique may increase its effectiveness.

title: XXXX : evaluation with contrast-specific sonography and a second-generation contrast medium: preliminary experience.

answer: @entity2


abstract: BACKGROUND: @entity3 is a very common @entity1 with a broad clinical spectrum. Biopsies are often used to confirm the diagnosis, especially when the clinical presentation is unusual. Not uncommonly organisms are hard to find even with Periodic acid-Schiff stains. Polymerase chain reaction (PCR) for dermatophytes can be used in such cases. OBJECTIVES: To test a new PCR-assay allowing species identification of dermatophytes on @entity2 -embedded biopsies; to reassess histopathological criteria for diagnosis of @entity3 . METHODS: 121 biopsies of 92 @entity0 with clinical suspicion of @entity3 were included. In 42 samples the clinical diagnosis had been confirmed histopathologically, in 79 no fungal elements had been identified. Polymerase chain reactions (PCR) targeting the ITS 2 region of dermatophytes were performed on the biopsies with subsequent sequencing. Sections were reassessed for the presence/absence of hyphae/spores, pattern and composition of infiltrate, epidermal/follicular changes. @entity0 charts were reviewed for clinical data. RESULTS: The new ITS2 PCR assay detected 94.3% of the dermatophyte infections (compared with 79.2% identified by microscopy). @entity4 was the dominant species (88.7%), other species identified were @entity5 (1.9%), @entity7 (3.8%), @entity8 (1.9%), T.interdigitale (3.8%). @entity6 with T.interdigitale and manifestations with prominent spongiosis were not diagnosed histologically. Intracorneal neutrophils which have been emphasized as a histopathological clue to @entity3 were present in only 46% of PCR-positive samples. CONCLUSIONS: Molecular species identification of dermatophytes via ITS2 PCR can easily be implemented in a routine dermatopathology setting. It is fast, highly specific, and improves the sensitivity of histopathological diagnosis of @entity3 . This article is protected by copyright. All rights reserved.

title: Species identification of dermatophytes in XXXX -embedded biopsies with a new PCR-assay targeting the ITS 2 region and comparison with histopathological features.

answer: @entity2