abstract: BACKGROUND AND PURPOSE: Botulinum toxin is increasingly used to treat upper limb @entity3 due to @entity1 , but its impact on arm function is unclear. We evaluated botulinum toxin for upper limb @entity3 and function poststroke. METHODS: Three hundred thirty-three @entity0 with @entity1 with upper limb @entity3 and reduced arm function participated in a multicenter randomized controlled trial. The intervention group received botulinum toxin type A injection(s) plus a 4-week therapy program. The control group received the therapy program alone. Repeat injection(s) and therapy were available at 3, 6, and 9 months. The primary outcome was @entity4 at 1 month (Action Research Arm Test). Secondary outcomes included measures of impairment, activity limitation, and @entity2 at 1, 3, and 12 months. Outcome assessments were blinded and analysis was by intention to treat. RESULTS: There was no significant difference in achievement of improved arm function (Action Research Arm Test) at 1 month (intervention group: 42 of 167 [25.1%], control group 30 of 154 [19.5%]; P=0.232). Significant differences in favor of the intervention group were seen in muscle tone at 1 month; upper limb strength at 3 months; basic arm functional tasks (hand hygiene, facilitation of dressing) at 1, 3, and 12 months; and @entity2 at 12 months. CONCLUSIONS: Botulinum toxin type A is unlikely to be useful for improving active @entity4 (eg, reaching and grasping) in the majority of @entity0 with @entity3 after @entity1 , but it may improve basic upper limb tasks (hand hygiene, facilitation of dressing) and @entity2 .

title: Botulinum Toxin for the Upper Limb after XXXX (BoTULS) Trial: effect on impairment, activity limitation, and @entity2 .

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Botulinum toxin is increasingly used to treat upper limb @entity3 due to @entity1 , but its impact on arm function is unclear. We evaluated botulinum toxin for upper limb @entity3 and function poststroke. METHODS: Three hundred thirty-three @entity0 with @entity1 with upper limb @entity3 and reduced arm function participated in a multicenter randomized controlled trial. The intervention group received botulinum toxin type A injection(s) plus a 4-week therapy program. The control group received the therapy program alone. Repeat injection(s) and therapy were available at 3, 6, and 9 months. The primary outcome was @entity4 at 1 month (Action Research Arm Test). Secondary outcomes included measures of impairment, activity limitation, and @entity2 at 1, 3, and 12 months. Outcome assessments were blinded and analysis was by intention to treat. RESULTS: There was no significant difference in achievement of improved arm function (Action Research Arm Test) at 1 month (intervention group: 42 of 167 [25.1%], control group 30 of 154 [19.5%]; P=0.232). Significant differences in favor of the intervention group were seen in muscle tone at 1 month; upper limb strength at 3 months; basic arm functional tasks (hand hygiene, facilitation of dressing) at 1, 3, and 12 months; and @entity2 at 12 months. CONCLUSIONS: Botulinum toxin type A is unlikely to be useful for improving active @entity4 (eg, reaching and grasping) in the majority of @entity0 with @entity3 after @entity1 , but it may improve basic upper limb tasks (hand hygiene, facilitation of dressing) and @entity2 .

title: Botulinum Toxin for the Upper Limb after @entity1 (BoTULS) Trial: effect on impairment, activity limitation, and XXXX .

answer: @entity2


abstract: Cell-cycle induction in hepatocytes protects from prolonged @entity5 after @entity1 . @entity9 (-/-) @entity0 exhibit @entity1 after @entity6 ( @entity8 ) exposure and reduced @entity2 production. Because @entity2 is required for prompt cell-cycle induction after @entity1 , here, we tested the hypothesis that @entity9 is required for timely hepatocyte entry into the cell cycle after @entity8 -induced @entity1 . @entity1 was induced by a single injection of @entity8 . Assays were employed to assess indices of the cell cycle in liver after @entity8 exposure. @entity4 incorporation peaked in wild-type @entity0 at 48 h after @entity8 but was reduced by 80% in @entity9 (-/-) @entity0 . Proliferating-cell nuclear-antigen immunohistochemistry revealed blocks in cell-cycle entry and progression to DNA synthesis in @entity9 -deficient @entity0 48 h after @entity8 . @entity7 D, important for G0/G1 progression, was reduced at baseline and 36 h after @entity8 . @entity10 , required for G1/S-phase transition, was reduced in @entity9 (-/-) @entity0 24 and 48 h after @entity8 exposure and was associated with reduced phosphorylation of the @entity3 protein. Proliferation in @entity9 (-/-) @entity0 was delayed, rather than blocked, because indices of cell-cycle progression were restored 72 h after @entity8 exposure. We concluded that @entity9 was required for prompt cell-cycle entry (G0- to G1-phase) and G1/S-phase transition after @entity1 . These data support the hypothesis that @entity9 provides hepatoprotection in the @entity8 -injured liver, attributable, in part, to timely cell-cycle induction and progression.

title: @entity9 is required for timely cell-cycle entry and progression in hepatocytes after acute XXXX exposure in @entity0 .

answer: @entity6


abstract: Cell-cycle induction in hepatocytes protects from prolonged @entity5 after @entity1 . @entity9 (-/-) @entity0 exhibit @entity1 after @entity6 ( @entity8 ) exposure and reduced @entity2 production. Because @entity2 is required for prompt cell-cycle induction after @entity1 , here, we tested the hypothesis that @entity9 is required for timely hepatocyte entry into the cell cycle after @entity8 -induced @entity1 . @entity1 was induced by a single injection of @entity8 . Assays were employed to assess indices of the cell cycle in liver after @entity8 exposure. @entity4 incorporation peaked in wild-type @entity0 at 48 h after @entity8 but was reduced by 80% in @entity9 (-/-) @entity0 . Proliferating-cell nuclear-antigen immunohistochemistry revealed blocks in cell-cycle entry and progression to DNA synthesis in @entity9 -deficient @entity0 48 h after @entity8 . @entity7 D, important for G0/G1 progression, was reduced at baseline and 36 h after @entity8 . @entity10 , required for G1/S-phase transition, was reduced in @entity9 (-/-) @entity0 24 and 48 h after @entity8 exposure and was associated with reduced phosphorylation of the @entity3 protein. Proliferation in @entity9 (-/-) @entity0 was delayed, rather than blocked, because indices of cell-cycle progression were restored 72 h after @entity8 exposure. We concluded that @entity9 was required for prompt cell-cycle entry (G0- to G1-phase) and G1/S-phase transition after @entity1 . These data support the hypothesis that @entity9 provides hepatoprotection in the @entity8 -injured liver, attributable, in part, to timely cell-cycle induction and progression.

title: XXXX is required for timely cell-cycle entry and progression in hepatocytes after acute @entity6 exposure in @entity0 .

answer: @entity9


abstract: Cell-cycle induction in hepatocytes protects from prolonged @entity5 after @entity1 . @entity9 (-/-) @entity0 exhibit @entity1 after @entity6 ( @entity8 ) exposure and reduced @entity2 production. Because @entity2 is required for prompt cell-cycle induction after @entity1 , here, we tested the hypothesis that @entity9 is required for timely hepatocyte entry into the cell cycle after @entity8 -induced @entity1 . @entity1 was induced by a single injection of @entity8 . Assays were employed to assess indices of the cell cycle in liver after @entity8 exposure. @entity4 incorporation peaked in wild-type @entity0 at 48 h after @entity8 but was reduced by 80% in @entity9 (-/-) @entity0 . Proliferating-cell nuclear-antigen immunohistochemistry revealed blocks in cell-cycle entry and progression to DNA synthesis in @entity9 -deficient @entity0 48 h after @entity8 . @entity7 D, important for G0/G1 progression, was reduced at baseline and 36 h after @entity8 . @entity10 , required for G1/S-phase transition, was reduced in @entity9 (-/-) @entity0 24 and 48 h after @entity8 exposure and was associated with reduced phosphorylation of the @entity3 protein. Proliferation in @entity9 (-/-) @entity0 was delayed, rather than blocked, because indices of cell-cycle progression were restored 72 h after @entity8 exposure. We concluded that @entity9 was required for prompt cell-cycle entry (G0- to G1-phase) and G1/S-phase transition after @entity1 . These data support the hypothesis that @entity9 provides hepatoprotection in the @entity8 -injured liver, attributable, in part, to timely cell-cycle induction and progression.

title: @entity9 is required for timely cell-cycle entry and progression in hepatocytes after acute @entity6 exposure in XXXX .

answer: @entity0


abstract: BACKGROUND: The increased distribution of crystalloid solution into the interstitial space may decrease the effectiveness of intravascular volume loading in @entity0 . We investigated whether preoperative hydration status after overnight fasting affects interstitial fluid redistribution and thus the magnitude of @entity1 during general anesthesia. METHODS: Sixty ASA physical status I/II @entity0 undergoing tympanoplasty fasted from midnight. Anesthesia was induced by @entity5 and @entity2 and maintained with @entity4 and @entity3 . Coinciding with the induction of anesthesia, 15 mL/kg acetated Ringer solution was infused IV over 60 minutes followed by 1 mL/kg acetated Ringer solution over the next 30 minutes. Urine osmolalities after induction of anesthesia and during the study period (pre-U( @entity6 ), post-U( @entity6 )) and percent decreases of whole-body bioelectrical resistance for extracellular fluid relative to baseline at the end of the study period (/\R(e)) were measured. @entity0 with a pre-U( @entity6 ) < the 25th percentile or with a pre-U( @entity6 ) > the 75th percentile of pre-U( @entity6 ) were categorized in the hydrated or the dehydrated group, respectively. A range of variables, including mean arterial blood pressure during the 30- to 90-minute period relative to baseline, and /\R(e), were compared between the groups. RESULTS: The dehydrated group (pre-U( @entity6 ) >759.5 mOsm/kg, n = 15) had a lower age (44 vs 52 years, P = 0.049) and had a higher post-U( @entity6 ) (181 vs 55 mOsm/kg, P = 0.001) compared with the hydrated group (pre-U( @entity6 ) <378.5 mOsm/kg, n = 15). Mean arterial blood pressure during the 30- to 90-minute period relative to baseline (0.67 vs 0.67, P = 0.85) with 95% confidence interval for the difference of means (-0.070 to 0.084) and /\R(e) (5.6% vs 6.0%, P = 0.58) with 95% confidence interval for the difference of means (-1.85% to 1.06%) were similar for the hydrated and dehydrated groups. CONCLUSIONS: Preoperative dehydration after overnight fasting as measured by urine osmolality did not alter the magnitude of @entity1 during general anesthesia. This finding suggests that intravascular volume loading with crystalloid solution to prevent @entity1 during general anesthesia is an unfounded practice for low risk @entity0 after overnight fasting.

title: Hydration status after overnight fasting as measured by urine osmolality does not alter the magnitude of XXXX during general anesthesia in low risk @entity0 .

answer: @entity1


abstract: BACKGROUND: The increased distribution of crystalloid solution into the interstitial space may decrease the effectiveness of intravascular volume loading in @entity0 . We investigated whether preoperative hydration status after overnight fasting affects interstitial fluid redistribution and thus the magnitude of @entity1 during general anesthesia. METHODS: Sixty ASA physical status I/II @entity0 undergoing tympanoplasty fasted from midnight. Anesthesia was induced by @entity5 and @entity2 and maintained with @entity4 and @entity3 . Coinciding with the induction of anesthesia, 15 mL/kg acetated Ringer solution was infused IV over 60 minutes followed by 1 mL/kg acetated Ringer solution over the next 30 minutes. Urine osmolalities after induction of anesthesia and during the study period (pre-U( @entity6 ), post-U( @entity6 )) and percent decreases of whole-body bioelectrical resistance for extracellular fluid relative to baseline at the end of the study period (/\R(e)) were measured. @entity0 with a pre-U( @entity6 ) < the 25th percentile or with a pre-U( @entity6 ) > the 75th percentile of pre-U( @entity6 ) were categorized in the hydrated or the dehydrated group, respectively. A range of variables, including mean arterial blood pressure during the 30- to 90-minute period relative to baseline, and /\R(e), were compared between the groups. RESULTS: The dehydrated group (pre-U( @entity6 ) >759.5 mOsm/kg, n = 15) had a lower age (44 vs 52 years, P = 0.049) and had a higher post-U( @entity6 ) (181 vs 55 mOsm/kg, P = 0.001) compared with the hydrated group (pre-U( @entity6 ) <378.5 mOsm/kg, n = 15). Mean arterial blood pressure during the 30- to 90-minute period relative to baseline (0.67 vs 0.67, P = 0.85) with 95% confidence interval for the difference of means (-0.070 to 0.084) and /\R(e) (5.6% vs 6.0%, P = 0.58) with 95% confidence interval for the difference of means (-1.85% to 1.06%) were similar for the hydrated and dehydrated groups. CONCLUSIONS: Preoperative dehydration after overnight fasting as measured by urine osmolality did not alter the magnitude of @entity1 during general anesthesia. This finding suggests that intravascular volume loading with crystalloid solution to prevent @entity1 during general anesthesia is an unfounded practice for low risk @entity0 after overnight fasting.

title: Hydration status after overnight fasting as measured by urine osmolality does not alter the magnitude of @entity1 during general anesthesia in low risk XXXX .

answer: @entity0


abstract: Normal unstimulated @entity1 lymph node lymphocytes (LNLs) migrated into filters in a gradient of @entity5 ( @entity5 ), heat-inactivated mouse serum (HI- @entity0 ), or zymosan-activated mouse serum (ZAS). Blind well chemotaxis chambers with 5-micrometer pore size cellulose @entity2 membranes were used. Migration was assessed both by the leading front technique and the mean aggregate number. A concentration of 2.5 x 10(6) LNLs/ml or greater was needed to detect migration. Migration of LNLs to 1% @entity5 was time dependent and was inhibited by @entity3 . Comparison of the migration patterns of LNLs, neutrophils, and macrophages revealed that all cell types were responsive to @entity5 . LNLs responded as well to HI- @entity0 as they did to @entity5 , neutrophils responded less well to HI- @entity0 than to @entity4 , and macrophages did not respond to HI- @entity0 . The LNL response to ZAS was significantly greater than the response to @entity5 to HI- @entity0 and neutrophils and macrophages also responded strongly to ZAS. The migration of LNLs from various @entity1 strains to @entity5 revealed that the LNLs from different @entity1 strains possess varying degree of motility. The factor in mouse serum which induced migration was not strain specific. The LNLs from peripheral (inguinal, axillary, and brachial) nodes demonstrated greater motility in response to @entity5 than mesenteric LNLs. Using the checkerboard assay to discriminate chemotaxis from chemokinesis, mouse serum appeared to be solely chemokinetic when the leading front technique was used. However, using the mean aggregate number technique, mouse serum was determined to be both chemokinetic acid chemotactic for LNLs. The results indicate that the method can be reliably used to study those factors which influence the motility of normal or altered populations of lymphocytes.

title: Migration of XXXX lymphocytes in vitro. I. Normal lymph node lymphocytes.

answer: @entity1


abstract: @entity3 ( @entity3 ) is a severe and rare disease, characterized by hematopoietic @entity2 and @entity1 . The pathophysiology is immune mediated in most cases, activated T1 lymphocytes have been identified as effector cells. The disease can be successfully treated with combined immunosuppressive therapy or allogeneic hematopoietic stem cell transplantation. @entity3 ( @entity3 ) is a syndrome of @entity2 following the development of @entity0 . @entity3 syndrome most often affects young males who presented severe @entity4 two to three months after an episode of @entity0 . The clinical course of @entity0 is more frequently benign but a fulminant severe course is also described. The @entity2 can be explosive and severe and it is usually fatal if untreated, no correlations have been observed between severity of @entity0 and @entity5 . In none of the studies a specific virus could be identified and most cases are seronegative for known @entity0 viruses. The clinical characteristics and response to immunotherapy indicate a central role for immune-mediated mechanism in the pathogenesis of @entity3 . The initial target organ of the immune response is the liver as suggested by the time interval between @entity0 and the onset of @entity2 . Liver histology is characterized by T cell infiltrating the parenchyma as reported in @entity0 . Recently in @entity3 it has been demonstrated intrahepatic and blood lymphocytes with T cell repertoire similar to that of confirmed viral @entity0 . The expanded T cell clones return to a normal distribution after response to immunosuppressive treatment, suggesting the antigen or T cell clearance. Therapeutic options are the same as acquired @entity3 .

title: Aplastica anemia and XXXX .

answer: @entity0


abstract: BACKGROUND: Black thyroid is a rare condition. It has been considered to be pathognomonic of chronic minocycline ingestion for more than 30 years, although it can also occur in @entity0 with @entity7 , @entity8 , @entity5 , and @entity3 . A possible association of black thyroid with @entity2 has been considered, but no direct causal relationship has been established. Hence, the purpose of this article was to identify the malignant potential of such glands. METHODS: A retrospective medical chart review was performed on 433 @entity0 who underwent thyroid surgery at Tulane University Medical Center from 2001 to 2008. @entity0 were grouped based on pathology: (1) benign, (2) @entity4 , and (3) @entity6 . RESULTS: At surgery, 63 @entity0 (15%) with black thyroid gland were found to have thyroid nodules. Among these nodules, 22 (35%) were benign, 21 (33%) contained @entity6 , and 20 (32%) had a non-papillary thyroid @entity1 . Nodules in black thyroids were associated with higher risk of @entity1 than nodules in non-black thyroids (p = .0001). Further analysis of the @entity6 group showed no statistical difference in regard to @entity1 size or evidence of multifocality of disease. CONCLUSION: The finding of a black thyroid gland is unusual and disconcerting. To our knowledge, this is the first study aimed at documenting the malignant potential of black thyroid glands. This report documents that the risk of @entity1 is higher in black thyroid compared to non-black thyroid glands. Furthermore, among those with @entity6 , the presence of the pigment did not correlate with @entity1 , multifocality, or @entity1 size.

title: XXXX in black thyroids.

answer: @entity6


abstract: AIM: The current study examined the preliminary efficacy of dialectical behaviour therapy ( @entity5 ) adapted for concurrent @entity3 ( @entity3 ) and @entity2 ( @entity2 ). METHOD: A matched randomized controlled trial was carried out with 25 female outpatients diagnosed with concurrent @entity4 and SUD. @entity0 randomized to the intervention condition received @entity5 , whereas those randomized to the control condition received treatment as usual (TAU), both for a period of 1   year. A series of measures related to @entity3 , substance use and @entity1 were administered to the @entity0 at the beginning of treatment and at 3, 6, 9 and 12 months into treatment, followed by 3-month and 6-month follow-up assessments. FINDINGS: @entity0 randomized to the @entity5 condition evidenced a superior retention rate relative to their counterparts in the TAU condition at various study time points, including post-treatment (80% versus 20%) and follow-up (60% versus 20%). Due to the unexpected elevated dropout rates and the worsening of @entity4 -SUD symptomatology in the TAU condition, recruitment efforts were terminated early. Results from the @entity5 condition revealed that the intervention had a significant positive effect on behavioural and attitudinal features of @entity3 , substance use severity and use, negative mood regulation and @entity1 . Finally, increases in @entity0 ' perceived ability to regulate and cope with negative emotional states were significantly associated with @entity3 and increases in levels of confidence in ability to resist urges for substance use. CONCLUSION: Results suggest that the adapted @entity5 might hold promise for treating individuals with concurrent @entity4 and SUD. KEY PRACTITIONER MESSAGE: The current study is the first study to report positive effects of @entity5 on individuals with concurrent eating and @entity2 . Although the results require replication and extension, they suggest that the @entity5 may be promising for this population. The results suggest that clinicians treating individuals with concurrent eating and substance use problems should be particularly cautious of poor treatment retention and treatment complications. The results bear upon the highly salient and important issue of whether individuals with concurrent substance use need to be excluded from research studies and treatment programmes.

title: Outcome of dialectical behaviour therapy for concurrent eating and XXXX .

answer: @entity2


abstract: The survival and the remission length of a group of 122 adult @entity0 with @entity1 have been studied: 45 Hodgkin (HG) and 77 @entity2 ( @entity2 ). The difference between the survival medians of the two groups turned out statistically significant (74.5 for HG cases and 43 for @entity2 ). Non significant survival differences were detected among HG with "favourable" and those with "non-favourable" histology. Determinant for the survival was the obtention of the complete remission both in HG and in @entity2 . As far as the treatment is concerned in relation to the stage, HG were broken down into three groups: radiotherapy alone, chemo + radiotherapy, chemotherapy only. The highest percentage of complete remissions (RC) was obtained in the group chemo + radiotherapy (100% of the treated) versus 80% on the group with the only radiotherapy and 53.3% of that with the only chemotherapy. The median length of the RC was, however, higher in the @entity0 treated with chemotherapy alone. After relapse a new RC easily obtained with chemotherapeutic treatment in the @entity0 treated with only radiotherapy in comparison with those already submitted to chemotherapy. As far as @entity2 is concerned, they were broken down according to the main histotype in lymphocytic and histiocytic. The groups, according to the treatment turned out two: radiotherapy plus chemotherapy and chemotherapy alone. The difference between the survival medians turned out highly statistically significant (43 and 36 cases respectively). Also statistically significant, but in favor of th histiocytic cases, the percentage of the @entity0 who maintained the CR (27 cases the lymphocytic versus 60 for the histiocytic) this in agreement with the literature data, according to which, even being the histotypes with the most unfavourable prognosis, the histiocytic, once attained the CR, tend to maintain the same, more longer in time, in comparison with the forms with favourable histology. The chemotherapeutic combinations employed by us are subsequently outlined extensively.

title: [Length of remission and survival in a group of @entity0 with XXXX ].

answer: @entity1


abstract: The survival and the remission length of a group of 122 adult @entity0 with @entity1 have been studied: 45 Hodgkin (HG) and 77 @entity2 ( @entity2 ). The difference between the survival medians of the two groups turned out statistically significant (74.5 for HG cases and 43 for @entity2 ). Non significant survival differences were detected among HG with "favourable" and those with "non-favourable" histology. Determinant for the survival was the obtention of the complete remission both in HG and in @entity2 . As far as the treatment is concerned in relation to the stage, HG were broken down into three groups: radiotherapy alone, chemo + radiotherapy, chemotherapy only. The highest percentage of complete remissions (RC) was obtained in the group chemo + radiotherapy (100% of the treated) versus 80% on the group with the only radiotherapy and 53.3% of that with the only chemotherapy. The median length of the RC was, however, higher in the @entity0 treated with chemotherapy alone. After relapse a new RC easily obtained with chemotherapeutic treatment in the @entity0 treated with only radiotherapy in comparison with those already submitted to chemotherapy. As far as @entity2 is concerned, they were broken down according to the main histotype in lymphocytic and histiocytic. The groups, according to the treatment turned out two: radiotherapy plus chemotherapy and chemotherapy alone. The difference between the survival medians turned out highly statistically significant (43 and 36 cases respectively). Also statistically significant, but in favor of th histiocytic cases, the percentage of the @entity0 who maintained the CR (27 cases the lymphocytic versus 60 for the histiocytic) this in agreement with the literature data, according to which, even being the histotypes with the most unfavourable prognosis, the histiocytic, once attained the CR, tend to maintain the same, more longer in time, in comparison with the forms with favourable histology. The chemotherapeutic combinations employed by us are subsequently outlined extensively.

title: [Length of remission and survival in a group of XXXX with @entity1 ].

answer: @entity0


abstract: From January 1961 to June 1978, 417 @entity0 with @entity2 were submitted to lymphangiography as part of the initial diagnostic work-up. As regards the distribution by clinical stage of the cases under consideration, there were 187 cases in Stage Ib (44.8%) 99 in Stage II (23.7%) and 131 in Stage III plus IV (31.5%). For the early stages preference was given to a radical surgery plus pre- or postoperative radiotherapy combination (154/417 @entity0 , or 36.9%). On the contrary, the cases which were more developed locally or which presented contra-indications to surgery received radiological treatment alone (263/417 cases, or 63.1%). The overall incidence of positive examinations was 29.9% (10.7% in Stage Ib; 28.3% in Stage II; 58.7% in Stage III and 60.0% in Stage IV). The histologic type on its own did not seem to influence the incidence of lymph node @entity1 detectable by lymphography. In the 145 @entity0 who had surgical exploration, the overall diagnostic accuracy of lymphography was 82.8% with 3 false positive and 22 false negative reports. The para-aortic chains were involved in 28/417 @entity0 (6.7%). For the negative cases, with all the stages mixed together, a 74.7% 5-year survival rate free of disease was recorded, as compared with the 34.5% found for the positive cases (P less than 0.0001). Similar differences was recorded stage by stage.

title: [Clinical value of lymphography in XXXX (author's transl)].

answer: @entity2


abstract: @entity8 is still an important topic for the infectious diseases specialist, due to it's high incidence, severity and it's high mortality rate. MATERIAL AND METHOD: We retrospectively studied 679 @entity0 diagnosed with community acquired @entity8 in the Infectious Diseases Hospital Ia  i, Romania between 1998 and 2007. RESULTS: The annual number of admissions slightly decreased in the last years. Most @entity0 were males (62.1%). Predisposing factors were present in 34.9% of cases. @entity2 were described in 19.6% of cases, more frequent in @entity0 . The CSF was purulent only in 69.4% of @entity0 , 29.6% of them receiving antibiotics prior to admission; the albumin level in the CSF of @entity6 was higher than in other @entity3 . The etiology was established in 51.6% of cases, more frequent in sucklings (68.1%). @entity7 was the most common cause of community acquired @entity8 (CABM) (28.5%) followed by @entity5 (14%). @entity5 was susceptible to @entity1 in 79% of cases. The mean mortality rate was 13.1%. CONCLUSION: Factors associated with a poor prognosis were: pneumococcal etiology, age over 60, and the presence of @entity2 or @entity4 at admission.

title: [Community acquired XXXX --a 10 year review].

answer: @entity8


abstract: Urinary tract injuries are rare lesions and account for about 3%, of all injuries and 10% of @entity4 . The aim of this study is to review retrospectively a series of @entity0 with urinary tract injuries treated in a general surgery clinic. MATERIAL AND METHODS: A series of 41 consecutive @entity0 with urinary tract @entity2 who hospitalized in Surgery Clinic of "St. John" Hospital of Ia  i during a 7 years period (January 2002 - December 2008). The main analyzed variable was age, mechanism of injury, anatomical site of injury, associated injuries, and methods of treatment, morbidity and mortality. RESULTS: Urinary tract injuries accounted for 3.2% of all @entity4 . Adults males were more affected with 90.2% of cases. Traffic road accident and falls represented over 50% of cases. @entity1 were present in 73.7% of cases, and associated lesions were present in all cases. Conservative treatment was applied for 24 @entity0 (58.5%), nephrectomy (total or partial) was performed in 9 cases, suture of the urethra 1 case, suture of the urinary bladder 5 cases and cystostomy in 3 cases. Conservative treatment failed in 24 cases (58.5%), @entity3 were present in 8 @entity0 (19.5%) and one @entity0 died due to associated lesions. CONCLUSIONS: Urinary tract injuries are rarely encountered in @entity2 settings, to a high index of suspicion is necessary to establish the diagnosis. @entity1 is the most fervently lesions and conservative treatment represent feasible solution for these.

title: [Urinary tract XXXX : anatomo-lesional, etiological and clinical considerations].

answer: @entity2


abstract: BACKGROUND AND OBJECTIVE: Clinical parameters such as probing depth and @entity2 on probing are commonly used for monitoring after periodontal treatment. However, these parameters have poor prognostic utility. The biomarker calprotectin is used to monitor conditions such as @entity1 because of its ability to predict disease activity. Levels of calprotectin in gingival crevicular fluid correlate with @entity3 severity and treatment outcome. The validity of calprotectin as predictor for future @entity3 activity has not yet been investigated. MATERIAL AND METHODS: Thirty-six subjects with generalized aggressive @entity4 were treated with scaling and root planing (SRP), and with adjunctive antimicrobial medications. Probing depth, clinical attachment level and @entity2 on probing were assessed at baseline, and 3 and 6mo after SRP. A gingival crevicular fluid sample was collected from the initially deepest site in each @entity0 3mo after SRP and analysed for calprotectin levels. Activity was defined as a probing depth increase of >0.5mm between 3 and 6mo at the sample site. The ability of individual parameters to predict activity was analysed by construction of receiver operating characteristic curves. RESULTS: Nine active sites were identified. Clinical attachment level, probing depth, @entity2 on probing and gingival crevicular fluid volume showed no predictive utility [area under the curve (AUC) <0.6, p>0.05]. However, calprotectin concentration (AUC=0.793, p=0.01) and the total amount/sample of calprotectin (AUC=0.776, p=0.02) significantly predicted activity. @entity0 with calprotectin levels above calculated cut-off values had significantly more active sites than @entity0 with negative results. CONCLUSION: Calprotectin levels were predictors of disease activity at both site and subject levels. The calculated cut-off values provide a dichotomous basis for prospective evaluation of calprotectin as a diagnostic marker for monitoring periodontal treatment.

title: Calprotectin levels in gingival crevicular fluid predict disease activity in @entity0 treated for generalized aggressive XXXX .

answer: @entity4


abstract: BACKGROUND AND OBJECTIVE: Clinical parameters such as probing depth and @entity2 on probing are commonly used for monitoring after periodontal treatment. However, these parameters have poor prognostic utility. The biomarker calprotectin is used to monitor conditions such as @entity1 because of its ability to predict disease activity. Levels of calprotectin in gingival crevicular fluid correlate with @entity3 severity and treatment outcome. The validity of calprotectin as predictor for future @entity3 activity has not yet been investigated. MATERIAL AND METHODS: Thirty-six subjects with generalized aggressive @entity4 were treated with scaling and root planing (SRP), and with adjunctive antimicrobial medications. Probing depth, clinical attachment level and @entity2 on probing were assessed at baseline, and 3 and 6mo after SRP. A gingival crevicular fluid sample was collected from the initially deepest site in each @entity0 3mo after SRP and analysed for calprotectin levels. Activity was defined as a probing depth increase of >0.5mm between 3 and 6mo at the sample site. The ability of individual parameters to predict activity was analysed by construction of receiver operating characteristic curves. RESULTS: Nine active sites were identified. Clinical attachment level, probing depth, @entity2 on probing and gingival crevicular fluid volume showed no predictive utility [area under the curve (AUC) <0.6, p>0.05]. However, calprotectin concentration (AUC=0.793, p=0.01) and the total amount/sample of calprotectin (AUC=0.776, p=0.02) significantly predicted activity. @entity0 with calprotectin levels above calculated cut-off values had significantly more active sites than @entity0 with negative results. CONCLUSION: Calprotectin levels were predictors of disease activity at both site and subject levels. The calculated cut-off values provide a dichotomous basis for prospective evaluation of calprotectin as a diagnostic marker for monitoring periodontal treatment.

title: Calprotectin levels in gingival crevicular fluid predict disease activity in XXXX treated for generalized aggressive @entity4 .

answer: @entity0


abstract: @entity3 is common as an emergency and should be accurately diagnosed and treated. We analysed 22 @entity0 with @entity3 admitted to the emergency unit of Dubrava University Hospital during a 4-year period. According to the American Association for the Surgery of @entity1 five-grade classification of @entity3 , there were 14 grade I, 6 grade II and 2 grade III cases. Diagnosis was mainly based on clinical and ultrasonography findings, and in some cases on cavernosography. Nineteen @entity0 underwent immediate surgery and three @entity0 received conservative therapy. On outpatient follow up, sexual function was assessed by use of the 5-item International Index of Erectile Function (IIEF-5) test at 3 and 12 months of injury. At 3-month follow up, moderate, mild and no @entity2 was recorded in 5, 6 and 11 @entity0 respectively (mean IIEF-5: 19.62). At 12-month follow up, mild @entity2 was found in only one @entity0 (IIEF-5: 20), whereas all other @entity0 were free from @entity2 (mean IIEF-5: 23.75). The 12-month follow up yielded a higher statistical difference (P < 0.001) when compared with 3-month follow up. Study results indicated that appropriate treatment of @entity3 resulted in complete recovery of sexual function within 12 months.

title: XXXX and effect on male sexual function.

answer: @entity3


abstract: Histopathological studies were carried out to determine whether or not an immunological reaction was involved in the treatment of @entity3 . The following conclusions could be drawn from them. (1) A low-dose irradiation on the primary @entity0 -nest intensified the interstitial reaction. (2) When @entity5 was administered after low-dose irradiation, the interstitial reaction was intensified more remarkably than with irradiation alone. Moreover, it was possible for @entity5 administration to restore the responsiveness of lymph nodes which had been inhibited by the irradiation. (3) Some of the observed morphological changes suggested the local occurrence of an immunological reaction. The following findings could be pointed out: (a) In the @entity1 of the uterine cervix, exudative cells consisting mainly of lymphocytes, plasma cells, and macrophages formed a barrier-like layer surrounding the @entity0 -nest. @entity2 accompanied by @entity4 cells were formed in the interstitial tissue. Moreover, lymphoid tissues with a germinal center were formed. (b) In lymph nodes of the region involved, responsiveness was enhanced in the paracortical area, or a germinal center formed with its responsiveness enhanced. (4) There was a correlation between the degree of interstitial reaction of the @entity1 and the survival results of a follow-up survey. There was also a correlation between the degree of enlargement of lymph nodes and the survival results of this survey.

title: A histological study on immune reaction of advanced uterine XXXX with regard to the effect of a low-dose irradiation and @entity5 .

answer: @entity3


abstract: Histopathological studies were carried out to determine whether or not an immunological reaction was involved in the treatment of @entity3 . The following conclusions could be drawn from them. (1) A low-dose irradiation on the primary @entity0 -nest intensified the interstitial reaction. (2) When @entity5 was administered after low-dose irradiation, the interstitial reaction was intensified more remarkably than with irradiation alone. Moreover, it was possible for @entity5 administration to restore the responsiveness of lymph nodes which had been inhibited by the irradiation. (3) Some of the observed morphological changes suggested the local occurrence of an immunological reaction. The following findings could be pointed out: (a) In the @entity1 of the uterine cervix, exudative cells consisting mainly of lymphocytes, plasma cells, and macrophages formed a barrier-like layer surrounding the @entity0 -nest. @entity2 accompanied by @entity4 cells were formed in the interstitial tissue. Moreover, lymphoid tissues with a germinal center were formed. (b) In lymph nodes of the region involved, responsiveness was enhanced in the paracortical area, or a germinal center formed with its responsiveness enhanced. (4) There was a correlation between the degree of interstitial reaction of the @entity1 and the survival results of a follow-up survey. There was also a correlation between the degree of enlargement of lymph nodes and the survival results of this survey.

title: A histological study on immune reaction of advanced uterine @entity3 with regard to the effect of a low-dose irradiation and XXXX .

answer: @entity5


abstract: OBJECTIVE: Publically available health Web sites may be able to provide support for teens with @entity2 in their transition to autonomy. This study examines teen use of health Web sites and identifies barriers and promoters of use. MATERIALS AND METHODS: One hundred eighty (n=180) teens, aged 13-18, were recruited from @entity3 and @entity1 specialty clinics and given a resource sheet listing selected publically available Web sites. Web sites were categorized as general health, teen health, disease specific ( @entity3 or @entity1 ), and disease management. One hundred twenty-nine (n=129) @entity0 completed a 3-month follow-up semistructured telephone interview that assessed subsequent use of resource sheet Web sites and collected verbatim comments regarding use. RESULTS: Sixty percent visited at least one Web site from the resource sheet. General health (38.8%) and teen health Web sites (38.0%) were most likely to be visited. Reasons for not visiting any site were categorized as lack of time, lack of interest, lack of Internet access, and lack of medical need. Teen health sites had the highest intention for continued use. Comments associated with willingness to continue use were categorized into the following themes: usefulness, ease, medical need, teen-specific features, and frequency of updates. Neither health literacy nor demographic factors were significantly associated with use. CONCLUSIONS: Making a first Web site visit generally leads to a desire for continued use, but teens will not make the first effort of visiting a Web site unless they are engaged and interested in their own health management. Teens are most willing to become regular users of Web sites that they perceive to be useful and to be targeted toward them.

title: What makes teens start using and keep using health information web sites? A mixed model analysis of teens with XXXX .

answer: @entity2


abstract: The aim of this study was to evaluate middle-term clinical results of @entity2 ( @entity2 ) to treat @entity1 ( @entity1 ). Between 2002 and 2007, 28 consecutive @entity0 received robot-assisted laparoscopic aortobifemoral bypass grafting (n = 24) or aortoiliac endarterectomy (n = 4). @entity0 were followed prospectively. @entity2 could be completed successfully in 24 @entity0 ; conversion to open surgery was necessary in four @entity0 (14%). Median operative time was 350 min. Median aortic clamping time was 70 min. Median hospital stay was five days. One @entity0 died within 30 days. Non-lethal complications occurred in four @entity0 (14%). Clinical symptoms improved in all @entity0 . Primary and secondary limb-based patencies at 36 months were 89% and 91%, respectively. In conclusion, @entity2 is a feasible and durable technique for @entity0 with @entity1 . Although operative times are long, @entity2 allows rapid postoperative recovery.

title: Mid-term results of @entity2 for XXXX .

answer: @entity1


abstract: The aim of this study was to evaluate middle-term clinical results of @entity2 ( @entity2 ) to treat @entity1 ( @entity1 ). Between 2002 and 2007, 28 consecutive @entity0 received robot-assisted laparoscopic aortobifemoral bypass grafting (n = 24) or aortoiliac endarterectomy (n = 4). @entity0 were followed prospectively. @entity2 could be completed successfully in 24 @entity0 ; conversion to open surgery was necessary in four @entity0 (14%). Median operative time was 350 min. Median aortic clamping time was 70 min. Median hospital stay was five days. One @entity0 died within 30 days. Non-lethal complications occurred in four @entity0 (14%). Clinical symptoms improved in all @entity0 . Primary and secondary limb-based patencies at 36 months were 89% and 91%, respectively. In conclusion, @entity2 is a feasible and durable technique for @entity0 with @entity1 . Although operative times are long, @entity2 allows rapid postoperative recovery.

title: Mid-term results of XXXX for @entity1 .

answer: @entity2


abstract: BACKGROUND AND AIMS: @entity3 is one of the few crops able to withstand periods of partial or even complete submergence. One of the adaptive traits of @entity3 is the constitutive presence and further development of aerenchyma which enables @entity0 to be transported to submerged organs. The development of lysigenous aerenchyma is promoted by @entity4 accumulating within the submerged plant tissues, although other signalling mechanisms may also co-exist. In this study, aerenchyma development was analysed in two @entity3 ( @entity3 ) varieties, 'FR13A' and 'Arborio Precoce', which show opposite traits in flooding response in terms of internode elongation and survival. METHODS: The growth and survival of @entity3 varieties under submergence was investigated in the leaf sheath of 'FR13A' and 'Arborio Precoce'. The possible involvement of @entity4 and reactive @entity0 species (ROS) was evaluated in relation to aerenchyma formation. Cell viability and DNA fragmentation were determined by FDA/FM4-64 staining and TUNEL assay, respectively. @entity4 production was monitored by gas chromatography and by analysing ACO gene expression. ROS production was measured by using Amplex Red assay kit and the fluorescent dye DCFH(2)-DA. The expression of APX1 was also evaluated. AVG and DPI solutions were used to test the effect of inhibiting @entity4 biosynthesis and ROS production, respectively. KEY RESULTS: Both the varieties displayed constitutive lysigenous aerenchyma formation, which was further enhanced when submerged. 'Arborio Precoce', which is characterized by fast elongation when submerged, showed active @entity4 biosynthetic machinery associated with increased aerenchymatous areas. 'FR13A', which harbours the Sub1A gene that limits growth during @entity0 deprivation, did not show any increase in @entity4 production after submersion but still displayed @entity1 . @entity2 levels increased in 'FR13A' but not in 'Arborio Precoce'. CONCLUSIONS: While @entity4 controls aerenchyma formation in the fast-elongating 'Arborio Precoce' variety, in 'FR13A' ROS accumulation plays an important role.

title: Distinct mechanisms for aerenchyma formation in leaf sheaths of XXXX genotypes displaying a quiescence or escape strategy for flooding tolerance.

answer: @entity3


abstract: OBJECTIVE: Influence of sacral nerve modulation (SNM) on cerebral somatosensory evoked potentials (SEP) was determined in @entity0 with @entity1 and @entity2 . BACKGROUND: Selection of @entity0 with @entity1 and @entity2 for SNM could be improved. METHODS: The latency (ms) of SEP induced by pudendal nerve stimulation was compared before (T0) and at 1 month during peripheral nerve evaluation (PNE) of SNM at frequencies of 21 Hz (T1) and 40 Hz (T2). The results were correlated with clinical outcome at 6 months. RESULTS: In 16 of 23 incontinent @entity0 with clinical "success" from SNM (Wexner @entity1 score  <=7), there was a significant difference between @entity3 latency at T0 and T2 (38.81 vs. 37.49 ms, P = 0.049). In the 7 with "failure," there was no change between T0 and T2. In 12 of 19 @entity2 @entity0 with "success" (Wexner @entity2 score  <=15), there was no difference between T0 and T2 @entity3 latency (39.28 vs. 38.25 ms, P = 0.374). In the 7 with "failure," there was a significant fall in @entity3 latency (41.20 vs. 39.30 ms, P = 0.047) but not to the normal range. The T0 @entity3 latency in incontinent @entity0 having "success" was significantly higher than in the normal range (P = 0.044). In @entity2 @entity0 it was significantly higher than in the normal range in both those with "success" (P = 0.001) and "failure" (P = 0.022). CONCLUSIONS: Measurement of @entity3 latency of SEP at baseline and at 1 month of SNM at a frequency of 40 Hz may help to predict the outcome of SNM and thus influence the decision for permanent implantation for @entity0 with @entity1 and @entity2 .

title: The effect of sacral nerve modulation on cerebral evoked potential latency in fecal @entity1 and XXXX .

answer: @entity2


abstract: OBJECTIVE: Influence of sacral nerve modulation (SNM) on cerebral somatosensory evoked potentials (SEP) was determined in @entity0 with @entity1 and @entity2 . BACKGROUND: Selection of @entity0 with @entity1 and @entity2 for SNM could be improved. METHODS: The latency (ms) of SEP induced by pudendal nerve stimulation was compared before (T0) and at 1 month during peripheral nerve evaluation (PNE) of SNM at frequencies of 21 Hz (T1) and 40 Hz (T2). The results were correlated with clinical outcome at 6 months. RESULTS: In 16 of 23 incontinent @entity0 with clinical "success" from SNM (Wexner @entity1 score  <=7), there was a significant difference between @entity3 latency at T0 and T2 (38.81 vs. 37.49 ms, P = 0.049). In the 7 with "failure," there was no change between T0 and T2. In 12 of 19 @entity2 @entity0 with "success" (Wexner @entity2 score  <=15), there was no difference between T0 and T2 @entity3 latency (39.28 vs. 38.25 ms, P = 0.374). In the 7 with "failure," there was a significant fall in @entity3 latency (41.20 vs. 39.30 ms, P = 0.047) but not to the normal range. The T0 @entity3 latency in incontinent @entity0 having "success" was significantly higher than in the normal range (P = 0.044). In @entity2 @entity0 it was significantly higher than in the normal range in both those with "success" (P = 0.001) and "failure" (P = 0.022). CONCLUSIONS: Measurement of @entity3 latency of SEP at baseline and at 1 month of SNM at a frequency of 40 Hz may help to predict the outcome of SNM and thus influence the decision for permanent implantation for @entity0 with @entity1 and @entity2 .

title: The effect of sacral nerve modulation on cerebral evoked potential latency in fecal XXXX and @entity2 .

answer: @entity1


abstract: OBJECTIVES: @entity5 , a decrease in tidal volume without a change in respiratory rate, is not easily detected by standard monitoring practices during sedation but can be detected by capnography. Our goal was to determine the frequency of @entity5 and its association with @entity2 in @entity0 undergoing sedation with @entity6 . METHODS: @entity0 who received intravenous @entity6 with or without @entity4 for sedation in a pediatric emergency department were prospectively enrolled. Heart rate, respiratory rate, pulse oximetry, and end-tidal @entity3 (ET( @entity1 )) levels were recorded every 30 seconds. RESULTS: Fifty-eight subjects were included in this study. Fifty percent of subjects had recorded ET( @entity1 ) values less than 30 mm Hg without a rise in respiratory rate. Twenty-eight percent of subjects experienced a decrease in pulse oximetry less than 95%. @entity0 who experienced a persistent decrease in ET( @entity1 ) at least 30 seconds in length were much more likely to have a persistent decrease in pulse oximetry than those with normal or transient decreases in ET( @entity1 ) (relative risk, 6.6; 95% confidence interval, 1.4-30.5). Decreases in ET( @entity1 ) occurred on an average of 3.7 minutes before decreases in pulse oximetry. CONCLUSIONS: @entity5 as detected by capnography is common in @entity0 undergoing sedation with @entity6 with or without @entity4 . @entity2 is frequently preceded by low ET( @entity1 ) levels. Further studies are needed to determine if the addition of routine monitoring with capnography can reduce the frequency of @entity2 in @entity0 undergoing sedation.

title: Detection of @entity5 by capnography and its association with XXXX in @entity0 undergoing sedation with @entity6 .

answer: @entity2


abstract: OBJECTIVES: @entity5 , a decrease in tidal volume without a change in respiratory rate, is not easily detected by standard monitoring practices during sedation but can be detected by capnography. Our goal was to determine the frequency of @entity5 and its association with @entity2 in @entity0 undergoing sedation with @entity6 . METHODS: @entity0 who received intravenous @entity6 with or without @entity4 for sedation in a pediatric emergency department were prospectively enrolled. Heart rate, respiratory rate, pulse oximetry, and end-tidal @entity3 (ET( @entity1 )) levels were recorded every 30 seconds. RESULTS: Fifty-eight subjects were included in this study. Fifty percent of subjects had recorded ET( @entity1 ) values less than 30 mm Hg without a rise in respiratory rate. Twenty-eight percent of subjects experienced a decrease in pulse oximetry less than 95%. @entity0 who experienced a persistent decrease in ET( @entity1 ) at least 30 seconds in length were much more likely to have a persistent decrease in pulse oximetry than those with normal or transient decreases in ET( @entity1 ) (relative risk, 6.6; 95% confidence interval, 1.4-30.5). Decreases in ET( @entity1 ) occurred on an average of 3.7 minutes before decreases in pulse oximetry. CONCLUSIONS: @entity5 as detected by capnography is common in @entity0 undergoing sedation with @entity6 with or without @entity4 . @entity2 is frequently preceded by low ET( @entity1 ) levels. Further studies are needed to determine if the addition of routine monitoring with capnography can reduce the frequency of @entity2 in @entity0 undergoing sedation.

title: Detection of @entity5 by capnography and its association with @entity2 in XXXX undergoing sedation with @entity6 .

answer: @entity0


abstract: OBJECTIVES: @entity5 , a decrease in tidal volume without a change in respiratory rate, is not easily detected by standard monitoring practices during sedation but can be detected by capnography. Our goal was to determine the frequency of @entity5 and its association with @entity2 in @entity0 undergoing sedation with @entity6 . METHODS: @entity0 who received intravenous @entity6 with or without @entity4 for sedation in a pediatric emergency department were prospectively enrolled. Heart rate, respiratory rate, pulse oximetry, and end-tidal @entity3 (ET( @entity1 )) levels were recorded every 30 seconds. RESULTS: Fifty-eight subjects were included in this study. Fifty percent of subjects had recorded ET( @entity1 ) values less than 30 mm Hg without a rise in respiratory rate. Twenty-eight percent of subjects experienced a decrease in pulse oximetry less than 95%. @entity0 who experienced a persistent decrease in ET( @entity1 ) at least 30 seconds in length were much more likely to have a persistent decrease in pulse oximetry than those with normal or transient decreases in ET( @entity1 ) (relative risk, 6.6; 95% confidence interval, 1.4-30.5). Decreases in ET( @entity1 ) occurred on an average of 3.7 minutes before decreases in pulse oximetry. CONCLUSIONS: @entity5 as detected by capnography is common in @entity0 undergoing sedation with @entity6 with or without @entity4 . @entity2 is frequently preceded by low ET( @entity1 ) levels. Further studies are needed to determine if the addition of routine monitoring with capnography can reduce the frequency of @entity2 in @entity0 undergoing sedation.

title: Detection of XXXX by capnography and its association with @entity2 in @entity0 undergoing sedation with @entity6 .

answer: @entity5


abstract: OBJECTIVES: @entity5 , a decrease in tidal volume without a change in respiratory rate, is not easily detected by standard monitoring practices during sedation but can be detected by capnography. Our goal was to determine the frequency of @entity5 and its association with @entity2 in @entity0 undergoing sedation with @entity6 . METHODS: @entity0 who received intravenous @entity6 with or without @entity4 for sedation in a pediatric emergency department were prospectively enrolled. Heart rate, respiratory rate, pulse oximetry, and end-tidal @entity3 (ET( @entity1 )) levels were recorded every 30 seconds. RESULTS: Fifty-eight subjects were included in this study. Fifty percent of subjects had recorded ET( @entity1 ) values less than 30 mm Hg without a rise in respiratory rate. Twenty-eight percent of subjects experienced a decrease in pulse oximetry less than 95%. @entity0 who experienced a persistent decrease in ET( @entity1 ) at least 30 seconds in length were much more likely to have a persistent decrease in pulse oximetry than those with normal or transient decreases in ET( @entity1 ) (relative risk, 6.6; 95% confidence interval, 1.4-30.5). Decreases in ET( @entity1 ) occurred on an average of 3.7 minutes before decreases in pulse oximetry. CONCLUSIONS: @entity5 as detected by capnography is common in @entity0 undergoing sedation with @entity6 with or without @entity4 . @entity2 is frequently preceded by low ET( @entity1 ) levels. Further studies are needed to determine if the addition of routine monitoring with capnography can reduce the frequency of @entity2 in @entity0 undergoing sedation.

title: Detection of @entity5 by capnography and its association with @entity2 in @entity0 undergoing sedation with XXXX .

answer: @entity6


abstract: Bilateral @entity2 from @entity1 is not uncommon. A number of techniques for urinary diversion have been used in selected @entity0 when uraemia develops. Reimplantation of the ureter(s) as an alternative to urinary diversion has been carried out in 21 @entity0 over a 7-year period. In 6 of these @entity0 bilateral reimplantation was done. In another 6 @entity0 reimplantation of the ureter was not possible and cutaneous ureterostomy was carried out. The overall survival time was 10.6 months. In 13 @entity0 living more than 6 months post-operatively, survival time was 1.8 years. Most @entity0 had severe uraemia and advanced (clinical stage III or IV) @entity1 . The immediate management of these @entity0 is outlined and the importance should be considered is stress. It is concluded that, whenever possible, ureteric reimplantation should be considered for relieving @entity2 in @entity0 selected for active treatment.

title: Reimplantation of the ureter in XXXX associated with bilateral @entity2 .

answer: @entity1


abstract: Bilateral @entity2 from @entity1 is not uncommon. A number of techniques for urinary diversion have been used in selected @entity0 when uraemia develops. Reimplantation of the ureter(s) as an alternative to urinary diversion has been carried out in 21 @entity0 over a 7-year period. In 6 of these @entity0 bilateral reimplantation was done. In another 6 @entity0 reimplantation of the ureter was not possible and cutaneous ureterostomy was carried out. The overall survival time was 10.6 months. In 13 @entity0 living more than 6 months post-operatively, survival time was 1.8 years. Most @entity0 had severe uraemia and advanced (clinical stage III or IV) @entity1 . The immediate management of these @entity0 is outlined and the importance should be considered is stress. It is concluded that, whenever possible, ureteric reimplantation should be considered for relieving @entity2 in @entity0 selected for active treatment.

title: Reimplantation of the ureter in @entity1 associated with bilateral XXXX .

answer: @entity2


abstract: OBJECTIVES: To compare the effects of stannous (Sn) and @entity1 (F) ions and their combination on acquired enamel pellicle (AEP) protein composition (proteome experiment), and protection against @entity3 (functional experiment). METHODS: In the proteome experiment, @entity0 enamel specimens were incubated in whole saliva supernatant for 24h for AEP formation. They were randomly assigned to 4 groups (n=10), according to the rinse treatment: Sn (800ppm/6.7mM, @entity5 ), F (225ppm/13mM, @entity4 ), Sn and F combination (Sn+F) and deionized water (DIW, negative control). The specimens were immersed 3* in the test rinses for 2min, 2h apart. Pellicles were collected, digested, and analyzed for protein content using liquid chromatography electrospray ionization tandem mass spectrometry. In the functional experiment, @entity0 enamel specimens (n=10) were similarly treated for pellicle formation. Then, they were subjected to a five-day @entity3 cycling model, consisting of 5min erosive challenges (15.6 mM @entity2 , pH 2.6, 6*/d) and 2min treatment with the rinses containing Sn, F or Sn+F (3*/d). Between the treatments, all specimens were incubated in whole saliva supernatant. Surface loss was determined by profilometry. RESULTS: Our proteome approach on @entity0 enamel identified 72 proteins that were common to all groups. AEP of enamel treated with Sn+F demonstrated higher abundance for most of the identified proteins than the other groups. The functional experiment showed reduction of enamel surface loss for Sn+F (89%), Sn (67%) and F (42%) compared to DIW (all significantly different, p<0.05). CONCLUSION: This study highlighted that anti- @entity3 rinses (e.g. Sn+F) can modify quantitatively and qualitatively the AEP formed on @entity0 enamel. Moreover, our study demonstrated a combinatory effect that amplified the anti-erosive protection on tooth surface.

title: The Impact of Stannous, XXXX Ions and Its Combination on Enamel Pellicle Proteome and @entity3 Prevention.

answer: @entity1


abstract: OBJECTIVES: To compare the effects of stannous (Sn) and @entity1 (F) ions and their combination on acquired enamel pellicle (AEP) protein composition (proteome experiment), and protection against @entity3 (functional experiment). METHODS: In the proteome experiment, @entity0 enamel specimens were incubated in whole saliva supernatant for 24h for AEP formation. They were randomly assigned to 4 groups (n=10), according to the rinse treatment: Sn (800ppm/6.7mM, @entity5 ), F (225ppm/13mM, @entity4 ), Sn and F combination (Sn+F) and deionized water (DIW, negative control). The specimens were immersed 3* in the test rinses for 2min, 2h apart. Pellicles were collected, digested, and analyzed for protein content using liquid chromatography electrospray ionization tandem mass spectrometry. In the functional experiment, @entity0 enamel specimens (n=10) were similarly treated for pellicle formation. Then, they were subjected to a five-day @entity3 cycling model, consisting of 5min erosive challenges (15.6 mM @entity2 , pH 2.6, 6*/d) and 2min treatment with the rinses containing Sn, F or Sn+F (3*/d). Between the treatments, all specimens were incubated in whole saliva supernatant. Surface loss was determined by profilometry. RESULTS: Our proteome approach on @entity0 enamel identified 72 proteins that were common to all groups. AEP of enamel treated with Sn+F demonstrated higher abundance for most of the identified proteins than the other groups. The functional experiment showed reduction of enamel surface loss for Sn+F (89%), Sn (67%) and F (42%) compared to DIW (all significantly different, p<0.05). CONCLUSION: This study highlighted that anti- @entity3 rinses (e.g. Sn+F) can modify quantitatively and qualitatively the AEP formed on @entity0 enamel. Moreover, our study demonstrated a combinatory effect that amplified the anti-erosive protection on tooth surface.

title: The Impact of Stannous, @entity1 Ions and Its Combination on Enamel Pellicle Proteome and XXXX Prevention.

answer: @entity3


abstract: UNASSIGNED: Livestock predation by large carnivores and their persecution by local communities are major conservation concerns. In order to prevent speculations and reduce conflicts, it is crucial to get detailed and accurate data on predators' dietary ecology, which is particularly important in @entity0 dominated landscapes where livestock densities are high. This is the case of the endangered Iberian wolf in Portugal, an endemic subspecies of the Iberian Peninsula, which has seen its population distribution and abundance decline throughout the 20th century. Accordingly, the diet of the Iberian wolf was analyzed, using scat analysis, in a humanized landscape in central Portugal. From 2011 to 2014, a total of 295 wolf scats were collected from transects distributed throughout the study area, prospected on a monthly basis. Scat analysis indicated a high dependence of Iberian wolf on livestock. @entity3 predominated the diet (62% of the scats), followed by @entity1 (20%) and @entity2 (13%); the only wild ungulate present in the scat analysis was the @entity4 (4% of the scats). Our results show that even though livestock constitute most part of wolves diet, different livestock species may represent different predation opportunities. We conclude that the high levels of livestock consumption may be a result of low diversity and density of wild ungulates that settles livestock as the only abundant prey for wolves. Our findings help on the understanding of the Iberian wolf feeding ecology and have implications for conflict management strategies. Finally, management implications are discussed and solutions are recommended.

title: To Eat or Not To Eat? The Diet of the Endangered Iberian Wolf (Canis lupus signatus) in a XXXX -Dominated Landscape in Central Portugal.

answer: @entity0


abstract: @entity1 is a gender-related disease that is especially prevalent in postmenopausal @entity0 . New drugs have been developed led by issues of interest and concerns about this disease, each one striving to be more effective and safer than the previous one. @entity4 is a new, third-generation, selective @entity2 receptor modulator. This drug is used to treat @entity1 in @entity0 with a high risk of @entity3 . @entity4 significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal @entity0 with normal or low bone mineral density. The risk of @entity3 in @entity0 with @entity1 was reduced by 42% (P < 0.05) after 3 years in a pivotal study. Five years later, the reduction was still 35% (P = 0.014). Post hoc analysis in @entity0 with a high risk of @entity3 showed a 50% reduced risk of nonvertebral @entity3 (P = 0.02) after 3 years and a 37% reduction (P = 0.06) after 5 years. @entity4 shows anti- @entity3 potential in the first few years after menopause and a greater antiestrogen effect at the level of the uterus. This has made this compound an appropriate option in young postmenopausal @entity0 with @entity1 and a risk of @entity3 .

title: @entity4 for the management of XXXX .

answer: @entity1


abstract: @entity1 is a gender-related disease that is especially prevalent in postmenopausal @entity0 . New drugs have been developed led by issues of interest and concerns about this disease, each one striving to be more effective and safer than the previous one. @entity4 is a new, third-generation, selective @entity2 receptor modulator. This drug is used to treat @entity1 in @entity0 with a high risk of @entity3 . @entity4 significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal @entity0 with normal or low bone mineral density. The risk of @entity3 in @entity0 with @entity1 was reduced by 42% (P < 0.05) after 3 years in a pivotal study. Five years later, the reduction was still 35% (P = 0.014). Post hoc analysis in @entity0 with a high risk of @entity3 showed a 50% reduced risk of nonvertebral @entity3 (P = 0.02) after 3 years and a 37% reduction (P = 0.06) after 5 years. @entity4 shows anti- @entity3 potential in the first few years after menopause and a greater antiestrogen effect at the level of the uterus. This has made this compound an appropriate option in young postmenopausal @entity0 with @entity1 and a risk of @entity3 .

title: XXXX for the management of @entity1 .

answer: @entity4


abstract: Pretreatment of anaesthetized @entity0 with @entity1 (A), 250 mg.kg-1, @entity8 (M) 3 mg.kg-1 or a combination of both (A + M) was done before @entity6 with a 1.0 ml autologous blood clot and compared with no pretreatment (C). Experiments were done until 10 survivors were present in each group. Mortality rate in controls (C) was 55 per cent ( @entity2 in less than 30 minutes) compared to zero in (A) and (A + M) and nine per cent in (M). Arterial blood pressure fell to 60 per cent of pre- @entity5 values two minutes after @entity5 in (C) but had returned to 85 per cent of pre- @entity5 values after 60 minutes. This compares with a drop to 82 per cent at two minutes and 83 per cent at 60 minutes in (A), a drop to 70 per cent at two minutes and 90 per cent at 60 minutes in (M) and a very small drop to 92 per cent at two minutes which was unchanged at 60 minutes in (A + M). Right ventricular pressure increased by 75 per cent after two minutes compared to pre- @entity5 values in (C) and was still elevated by 37 per cent after 60 minutes. This compares with increases at two minutes and 60 minutes respectively of 58 and 23 per cent in (A), 65 and 35 per cent in (M) and 55 and 18 per cent in (A + M). Heart rate did not show any significant changes in any of the groups after @entity5 . These results show a dramatic reduction in mortality from @entity6 with @entity1 or @entity8 pretreatment, which is associated with significant attenuation of the @entity3 response seen in controls. These agents may act by inhibiting the actions of a release of @entity7 and @entity4 . The additive effects of the combination used suggests that both mediators may play a role in the haemodynamic responses to @entity6 .

title: The effects of XXXX and @entity8 , singly and in combination, on systemic haemodynamic responses to @entity6 .

answer: @entity1


abstract: Pretreatment of anaesthetized @entity0 with @entity1 (A), 250 mg.kg-1, @entity8 (M) 3 mg.kg-1 or a combination of both (A + M) was done before @entity6 with a 1.0 ml autologous blood clot and compared with no pretreatment (C). Experiments were done until 10 survivors were present in each group. Mortality rate in controls (C) was 55 per cent ( @entity2 in less than 30 minutes) compared to zero in (A) and (A + M) and nine per cent in (M). Arterial blood pressure fell to 60 per cent of pre- @entity5 values two minutes after @entity5 in (C) but had returned to 85 per cent of pre- @entity5 values after 60 minutes. This compares with a drop to 82 per cent at two minutes and 83 per cent at 60 minutes in (A), a drop to 70 per cent at two minutes and 90 per cent at 60 minutes in (M) and a very small drop to 92 per cent at two minutes which was unchanged at 60 minutes in (A + M). Right ventricular pressure increased by 75 per cent after two minutes compared to pre- @entity5 values in (C) and was still elevated by 37 per cent after 60 minutes. This compares with increases at two minutes and 60 minutes respectively of 58 and 23 per cent in (A), 65 and 35 per cent in (M) and 55 and 18 per cent in (A + M). Heart rate did not show any significant changes in any of the groups after @entity5 . These results show a dramatic reduction in mortality from @entity6 with @entity1 or @entity8 pretreatment, which is associated with significant attenuation of the @entity3 response seen in controls. These agents may act by inhibiting the actions of a release of @entity7 and @entity4 . The additive effects of the combination used suggests that both mediators may play a role in the haemodynamic responses to @entity6 .

title: The effects of @entity1 and @entity8 , singly and in combination, on systemic haemodynamic responses to XXXX .

answer: @entity6


abstract: Pretreatment of anaesthetized @entity0 with @entity1 (A), 250 mg.kg-1, @entity8 (M) 3 mg.kg-1 or a combination of both (A + M) was done before @entity6 with a 1.0 ml autologous blood clot and compared with no pretreatment (C). Experiments were done until 10 survivors were present in each group. Mortality rate in controls (C) was 55 per cent ( @entity2 in less than 30 minutes) compared to zero in (A) and (A + M) and nine per cent in (M). Arterial blood pressure fell to 60 per cent of pre- @entity5 values two minutes after @entity5 in (C) but had returned to 85 per cent of pre- @entity5 values after 60 minutes. This compares with a drop to 82 per cent at two minutes and 83 per cent at 60 minutes in (A), a drop to 70 per cent at two minutes and 90 per cent at 60 minutes in (M) and a very small drop to 92 per cent at two minutes which was unchanged at 60 minutes in (A + M). Right ventricular pressure increased by 75 per cent after two minutes compared to pre- @entity5 values in (C) and was still elevated by 37 per cent after 60 minutes. This compares with increases at two minutes and 60 minutes respectively of 58 and 23 per cent in (A), 65 and 35 per cent in (M) and 55 and 18 per cent in (A + M). Heart rate did not show any significant changes in any of the groups after @entity5 . These results show a dramatic reduction in mortality from @entity6 with @entity1 or @entity8 pretreatment, which is associated with significant attenuation of the @entity3 response seen in controls. These agents may act by inhibiting the actions of a release of @entity7 and @entity4 . The additive effects of the combination used suggests that both mediators may play a role in the haemodynamic responses to @entity6 .

title: The effects of @entity1 and XXXX , singly and in combination, on systemic haemodynamic responses to @entity6 .

answer: @entity8


abstract: BACKGROUND: While some studies have shown that long-limb gastric bypass with Roux limb length of 150 to 200 cm can attain better @entity2 outcomes in @entity1 @entity0 (BMI >50 kg/m(2)) than the standard limb gastric bypass with Roux limb length of 100 to 150 cm, other studies have not shown similar findings. Additionally, no study has demonstrated the optimal length of the Roux limb that will result in ideal @entity2 . The purpose of this study is to compare the long-term @entity2 and weight regain of @entity3 ( @entity3 ) and long limb length (LLL) gastric bypass in @entity0 with BMI >50 kg/m(2). METHODS: A total of 120 @entity0 with BMI >50 kg/m(2) underwent either @entity3 (total bypass length   =   200, biliopancreatic limb   =   50-80 cm, Roux limb   =   120-150 cm) or LLL (total bypass length = 250 biliopancreatic limb   =   50-80 cm, Roux limb   =   170-200 cm) RYGB. The excess @entity2 (EWL), the weight regain, and the rate of complications were measured at 1-, 2-, and 3-year follow-up. Statistical comparisons were performed using t-test. RESULTS: There was no difference in @entity0 demographics, pre-operative BMI, or comorbidities between the two groups: @entity3 (n   =   55) and LLL (n   =   65). In comparing standard- to long-limb cohorts, preoperative BMI was 56.1   5.34 vs. 57.5        6.05 kg/m(2), respectively. There was no statistical difference in percent EWL at 1, 2, and 3 years between the two groups [55.2 vs. 55 (P   =   0.933), 61.5 vs. 60.8 (P   =   0.831), and 61.1 vs.60 (P   =   0.932)]. There was no difference in percent weight regain between the two groups, 11.2 ( @entity3 ) and 5.2 (LLL) (P   =   0.13). The rates of complications were similar in the two groups. CONCLUSION: There is no difference in @entity2 or weight regain between the @entity3 and LLL RYGB. Longer-limb gastric bypass is not required in @entity0 with BMI >50 kg/m(2) for them to obtain long-term, sustained @entity2 .

title: Is XXXX better sustained with long-limb gastric bypass in the @entity1 ?

answer: @entity2


abstract: BACKGROUND: While some studies have shown that long-limb gastric bypass with Roux limb length of 150 to 200 cm can attain better @entity2 outcomes in @entity1 @entity0 (BMI >50 kg/m(2)) than the standard limb gastric bypass with Roux limb length of 100 to 150 cm, other studies have not shown similar findings. Additionally, no study has demonstrated the optimal length of the Roux limb that will result in ideal @entity2 . The purpose of this study is to compare the long-term @entity2 and weight regain of @entity3 ( @entity3 ) and long limb length (LLL) gastric bypass in @entity0 with BMI >50 kg/m(2). METHODS: A total of 120 @entity0 with BMI >50 kg/m(2) underwent either @entity3 (total bypass length   =   200, biliopancreatic limb   =   50-80 cm, Roux limb   =   120-150 cm) or LLL (total bypass length = 250 biliopancreatic limb   =   50-80 cm, Roux limb   =   170-200 cm) RYGB. The excess @entity2 (EWL), the weight regain, and the rate of complications were measured at 1-, 2-, and 3-year follow-up. Statistical comparisons were performed using t-test. RESULTS: There was no difference in @entity0 demographics, pre-operative BMI, or comorbidities between the two groups: @entity3 (n   =   55) and LLL (n   =   65). In comparing standard- to long-limb cohorts, preoperative BMI was 56.1   5.34 vs. 57.5        6.05 kg/m(2), respectively. There was no statistical difference in percent EWL at 1, 2, and 3 years between the two groups [55.2 vs. 55 (P   =   0.933), 61.5 vs. 60.8 (P   =   0.831), and 61.1 vs.60 (P   =   0.932)]. There was no difference in percent weight regain between the two groups, 11.2 ( @entity3 ) and 5.2 (LLL) (P   =   0.13). The rates of complications were similar in the two groups. CONCLUSION: There is no difference in @entity2 or weight regain between the @entity3 and LLL RYGB. Longer-limb gastric bypass is not required in @entity0 with BMI >50 kg/m(2) for them to obtain long-term, sustained @entity2 .

title: Is @entity2 better sustained with long-limb gastric bypass in the XXXX ?

answer: @entity1


abstract: Twenty-nine @entity0 with @entity1 were treated with a combination of @entity5 and @entity4 . @entity0 with adequate bone marrow reserve received @entity5 100 mg/m2 orally on day 1 and @entity4 0.3 mg/m2/day intravenously for five days. Both drugs were repeated every four weeks. @entity0 with inadequate bone marrow reserve received @entity5 75 mg/m2 and @entity4 0.2 mg/m2/day for five days. All @entity0 had received prior chemotherapy and had progressive disease at the start of the study. There was one complete response in a @entity0 with peritoneal @entity3 which lasted 18 months and the @entity0 is still alive at 38+ months. Ten @entity0 had stable disease including three @entity0 who had responses between 25% to 50%. No responses were seen in 18 @entity0 . The median time to progression for @entity0 with stable disease was five months and for those with progressive disease was two months (P = 0.001). The median survival for @entity0 with stable disease was 20 months compared with three months for @entity0 with progressive disease (P = 0.001). The combination was generally very well tolerated and myelosuppression was insignificant. However, with the dosages and schedule used in this study, the combination of @entity5 and @entity4 does not appear to have significant activity in advanced soft tissue @entity2 . Further studies with this combination are indicated in @entity0 with @entity3 .

title: A phase II evaluation of XXXX and @entity4 in the treatment of advanced @entity2 in adults.

answer: @entity5


abstract: Twenty-nine @entity0 with @entity1 were treated with a combination of @entity5 and @entity4 . @entity0 with adequate bone marrow reserve received @entity5 100 mg/m2 orally on day 1 and @entity4 0.3 mg/m2/day intravenously for five days. Both drugs were repeated every four weeks. @entity0 with inadequate bone marrow reserve received @entity5 75 mg/m2 and @entity4 0.2 mg/m2/day for five days. All @entity0 had received prior chemotherapy and had progressive disease at the start of the study. There was one complete response in a @entity0 with peritoneal @entity3 which lasted 18 months and the @entity0 is still alive at 38+ months. Ten @entity0 had stable disease including three @entity0 who had responses between 25% to 50%. No responses were seen in 18 @entity0 . The median time to progression for @entity0 with stable disease was five months and for those with progressive disease was two months (P = 0.001). The median survival for @entity0 with stable disease was 20 months compared with three months for @entity0 with progressive disease (P = 0.001). The combination was generally very well tolerated and myelosuppression was insignificant. However, with the dosages and schedule used in this study, the combination of @entity5 and @entity4 does not appear to have significant activity in advanced soft tissue @entity2 . Further studies with this combination are indicated in @entity0 with @entity3 .

title: A phase II evaluation of @entity5 and @entity4 in the treatment of advanced XXXX in adults.

answer: @entity2


abstract: Twenty-nine @entity0 with @entity1 were treated with a combination of @entity5 and @entity4 . @entity0 with adequate bone marrow reserve received @entity5 100 mg/m2 orally on day 1 and @entity4 0.3 mg/m2/day intravenously for five days. Both drugs were repeated every four weeks. @entity0 with inadequate bone marrow reserve received @entity5 75 mg/m2 and @entity4 0.2 mg/m2/day for five days. All @entity0 had received prior chemotherapy and had progressive disease at the start of the study. There was one complete response in a @entity0 with peritoneal @entity3 which lasted 18 months and the @entity0 is still alive at 38+ months. Ten @entity0 had stable disease including three @entity0 who had responses between 25% to 50%. No responses were seen in 18 @entity0 . The median time to progression for @entity0 with stable disease was five months and for those with progressive disease was two months (P = 0.001). The median survival for @entity0 with stable disease was 20 months compared with three months for @entity0 with progressive disease (P = 0.001). The combination was generally very well tolerated and myelosuppression was insignificant. However, with the dosages and schedule used in this study, the combination of @entity5 and @entity4 does not appear to have significant activity in advanced soft tissue @entity2 . Further studies with this combination are indicated in @entity0 with @entity3 .

title: A phase II evaluation of @entity5 and XXXX in the treatment of advanced @entity2 in adults.

answer: @entity4


abstract: Seven @entity0 (five female, two male) had locally advanced @entity3 of the anal canal. Three @entity0 had recurrent or persistent disease previously treated and four had advanced primary @entity2 . Five @entity0 had groin node @entity1 . The treatment protocol consisted of chemotherapy with continuous 5-day infusion of @entity5 , 750 mg/m2, and @entity4 , 15 mg/m2, by bolus injection and radiation 3000 rads. All @entity0 received one or two cycles of chemotherapy pre-operatively and four (not previously irradiated) received radiation. Tumor regression greater than 50% occurred in five @entity0 , minor regression (25-50%) occurred in one @entity0 and one @entity0 showed no regression (on chemotherapy alone). All @entity0 had total resection of all gross @entity2 with microscopic clear margins and five had groin dissection. One @entity0 had no @entity2 in specimen and one @entity0 had a microscopic focus only. Four of five @entity0 had residual nodal metastases at groin dissection. Currently three @entity0 are free of disease at 24, 24, and 26 months. Two @entity0 died with disease at 6 months and 34 months, and two @entity0 died of other causes while still free of disease, at 4 and 5 months after resection. Multimodality therapy of locally advanced epidermoid @entity2 of anal canal can provide effective control and palliation of many of these @entity2 and, in some, possibly effect cure.

title: Multimodality approach to surgical management of locally advanced XXXX of the anorectum.

answer: @entity3


abstract: BACKGROUND: The number of @entity0 suffering from a @entity1 is increasing. In many cases @entity3 can only be reconstructed by using a free @entity6 . The free parascapular @entity6 is an alternative to free @entity2 in the reconstruction of plantar or heel defects. Donor site morbidity is low. Autologous bypass reconstruction or an angioplasty can increase extremity perfusion. @entity0 AND OPERATIONS: 52 @entity0 with a @entity1 have been reconstructed since 2007. 23 of them required a free tissue transfer. On average these @entity0 were 68.7 years of age. A parascapular @entity6 was used in 15 cases, a latissimus dorsi @entity6 with a skin graft in 4 cases, a gracilis muscle @entity6 with a skin graft in 3 cases. In one case a free instep @entity6 of the contralateral foot, which had to be amputated, was used. In 13 cases the @entity6 was anastomosed to the autologous bypass, in one case an AV loop was used. RESULTS: 22 flaps healed primarily. Only 1 @entity0 was not able to walk at discharge. There was one @entity6 loss. 4 @entity0 required an amputation later on due to bypass @entity4 . 2 @entity0 died due to @entity5 at the rehabilitation clinic. CONCLUSION: If the correct indication is met, free flaps can prevent @entity1 -derived amputations of the lower limb. The parascapular @entity6 can be used for plantar and heel defects. @entity6 harvesting is quick due to the constant vascular anatomy. The donor site morbidity is low. Reconstruction requires revascularisation in an interdisciplinary setting including vascular surgeons and radiologists. Limb salvage reduces mortality and improves quality of life. Revascularisation and reconstruction should best be done in a single surgical procedure.

title: [Preventing lower limb amputations in @entity0 suffering from XXXX and peripheral vascular disease - opportunities and limitations].

answer: @entity1


abstract: BACKGROUND: The number of @entity0 suffering from a @entity1 is increasing. In many cases @entity3 can only be reconstructed by using a free @entity6 . The free parascapular @entity6 is an alternative to free @entity2 in the reconstruction of plantar or heel defects. Donor site morbidity is low. Autologous bypass reconstruction or an angioplasty can increase extremity perfusion. @entity0 AND OPERATIONS: 52 @entity0 with a @entity1 have been reconstructed since 2007. 23 of them required a free tissue transfer. On average these @entity0 were 68.7 years of age. A parascapular @entity6 was used in 15 cases, a latissimus dorsi @entity6 with a skin graft in 4 cases, a gracilis muscle @entity6 with a skin graft in 3 cases. In one case a free instep @entity6 of the contralateral foot, which had to be amputated, was used. In 13 cases the @entity6 was anastomosed to the autologous bypass, in one case an AV loop was used. RESULTS: 22 flaps healed primarily. Only 1 @entity0 was not able to walk at discharge. There was one @entity6 loss. 4 @entity0 required an amputation later on due to bypass @entity4 . 2 @entity0 died due to @entity5 at the rehabilitation clinic. CONCLUSION: If the correct indication is met, free flaps can prevent @entity1 -derived amputations of the lower limb. The parascapular @entity6 can be used for plantar and heel defects. @entity6 harvesting is quick due to the constant vascular anatomy. The donor site morbidity is low. Reconstruction requires revascularisation in an interdisciplinary setting including vascular surgeons and radiologists. Limb salvage reduces mortality and improves quality of life. Revascularisation and reconstruction should best be done in a single surgical procedure.

title: [Preventing lower limb amputations in XXXX suffering from @entity1 and peripheral vascular disease - opportunities and limitations].

answer: @entity0


abstract: BACKGROUND: The objective of this study was to evaluate the clinical outcome of proton and @entity4 ion therapy for @entity3 ( @entity3 ). METHODS: In total, 343 consecutive @entity0 with 386 @entity1 , including 242 @entity0 (with 278 @entity1 ) who received proton therapy and 101 @entity0 (with 108 @entity1 ) who received @entity4 ion therapy, were treated on 8 different protocols of proton therapy (52.8-84.0 gray equivalents [GyE] in 4-38 fractions) and on 4 different protocols of @entity4 ion therapy (52.8-76.0 GyE in 4-20 fractions). RESULTS: The 5-year local control and overall survival rates for all @entity0 were 90.8% and 38.2%, respectively. Regarding proton and @entity4 ion therapy, the 5-year local control rates were 90.2% and 93%, respectively, and the 5-year overall survival rates were 38% and 36.3%, respectively. These rates did not differ significantly between the 2 therapies. Univariate analysis identified @entity1 size as an independent risk factor for local recurrence in proton therapy, @entity4 ion therapy, and in all @entity0 . Multivariate analysis identified @entity1 size as the only independent risk factor for local recurrence in proton therapy and in all @entity0 . @entity0 -Pugh classification was the only independent risk factor for overall survival in proton therapy, in @entity4 ion therapy, and in all @entity0 according to both univariate and multivariate analyses. No @entity0 died of treatment-related @entity2 . CONCLUSIONS: Proton and @entity4 ion therapies for @entity3 were comparable in terms of local control and overall survival rates. These therapies may represent innovative alternatives to conventional local therapies for @entity3 .

title: Clinical results and risk factors of proton and XXXX ion therapy for @entity3 .

answer: @entity4


abstract: BACKGROUND: The objective of this study was to evaluate the clinical outcome of proton and @entity4 ion therapy for @entity3 ( @entity3 ). METHODS: In total, 343 consecutive @entity0 with 386 @entity1 , including 242 @entity0 (with 278 @entity1 ) who received proton therapy and 101 @entity0 (with 108 @entity1 ) who received @entity4 ion therapy, were treated on 8 different protocols of proton therapy (52.8-84.0 gray equivalents [GyE] in 4-38 fractions) and on 4 different protocols of @entity4 ion therapy (52.8-76.0 GyE in 4-20 fractions). RESULTS: The 5-year local control and overall survival rates for all @entity0 were 90.8% and 38.2%, respectively. Regarding proton and @entity4 ion therapy, the 5-year local control rates were 90.2% and 93%, respectively, and the 5-year overall survival rates were 38% and 36.3%, respectively. These rates did not differ significantly between the 2 therapies. Univariate analysis identified @entity1 size as an independent risk factor for local recurrence in proton therapy, @entity4 ion therapy, and in all @entity0 . Multivariate analysis identified @entity1 size as the only independent risk factor for local recurrence in proton therapy and in all @entity0 . @entity0 -Pugh classification was the only independent risk factor for overall survival in proton therapy, in @entity4 ion therapy, and in all @entity0 according to both univariate and multivariate analyses. No @entity0 died of treatment-related @entity2 . CONCLUSIONS: Proton and @entity4 ion therapies for @entity3 were comparable in terms of local control and overall survival rates. These therapies may represent innovative alternatives to conventional local therapies for @entity3 .

title: Clinical results and risk factors of proton and @entity4 ion therapy for XXXX .

answer: @entity3


abstract: BACKGROUND: Probiotics may alter immune regulation. Recently, we showed that the probiotic bacteria @entity5    influenced the activity of regulatory T cells (Tregs) in vitro. The aim of the present work was to demonstrate if @entity5    also affects the function of Tregs in vivo. METHODS: Development of @entity3 after transfer of CD4+CD25- T cells and protection from @entity3 by Tregs was studied in immunodeficient @entity2 @entity0 which were simultaneously tube-fed with @entity5    or @entity4 Ls-33 for 5 weeks. RESULTS: Probiotic-fed @entity2 @entity0 transplanted with low numbers of Tregs in addition to the disease-inducing T cells were completely protected from @entity3 . This was in contrast to the control group, which showed intermediate levels of @entity1 . In addition, feeding with probiotics lowered serum levels of inflammatory cytokines in both colitic @entity0 and in @entity0 protected from @entity3 by Tregs. Gene expression patterns of rectum samples of protected @entity0 that receive either one of the probiotics showed a closer resemblance to na  ve @entity2 @entity0 than did patterns of the control group. The mechanism of action of the probiotics appears to be an indirect effect by inducing a Treg-favorable environment rather than a direct effect on the Tregs. CONCLUSIONS: @entity5    and @entity4 Ls-33 feeding of @entity2 @entity0 increases the in vivo effect of Tregs, resulting in a gene expression pattern in the rectum resembling that of the na  ve @entity2 @entity0 .

title: Consumption of probiotics increases the effect of regulatory T cells in transfer XXXX .

answer: @entity3


abstract: BACKGROUND: The aim of this analysis was to identify if the modified indications of radiotherapy (RT) or radical surgery compromised survival in pediatric @entity4 ( @entity4 ). PROCEDURE: @entity0 with non-metastatic @entity4 , prospectively enrolled in three trials, were analyzed. After primary surgery or biopsy, they received chemotherapy. RT was planned after chemotherapy in @entity0 who had not achieved a complete response (CR). The considered outcome was 5-year @entity3 ( @entity3 ) and event-free survival (EFS). RESULTS: Eighty-eight @entity0 were identified. @entity1 were mainly located in limbs (66%). The first-line therapy for 65 @entity0 was primary resection. Of the 49 @entity0 who had gross @entity1 resection, 43 received adjuvant chemotherapy, and 8 had RT. All of the 39 @entity0 with macroscopic residual disease received chemotherapy, then only surgery (n = 12)    RT (n = 22). The 5-year EFS and @entity3 rates were 68% and 85%, respectively. The @entity5 stage was a prognostic factor for relapse, whereas primary site of the @entity1 and @entity5 stage were prognostic factors for @entity2 . CONCLUSIONS: Only 32% of survivors received RT. @entity3 was similar to published data. Omission of RT may be considered in younger @entity0 , to limit the potential sequelae in @entity0 with @entity1 less than 5 cm in size initially submitted to marginal resection. This strategy may also be considered in initially unresected cases, when the @entity1 is resected at delayed surgery with microscopically free margins, and in @entity0 in complete remission after primary chemotherapy.

title: Sparing strategy does not compromise prognosis in pediatric localized XXXX : experience of the International Society of Pediatric Oncology, Malignant Mesenchymal Tumors (SIOP-MMT) Working Group.

answer: @entity4


abstract: BACKGROUND: Oral colonization with Candida species has been observed in upto 93% of @entity0 receiving radiation for @entity2 . With immunosuppression there is a trend of emergence of rare species. The present study aimed to assess species and colonization of candida at different stages of radiation therapy for @entity2 . METHODS: Oral rinses of thirty @entity1 @entity0 receiving a six weeks course of radiation therapy for @entity2 were taken at two intervals; first at the start of radiation (0 Grays), and second at completion of radiation (60 Grays). The oral rinse was streaked onto a differential media (CHROMagar  ) plates and incubated at 37  C for 48 hours. Colony forming units (CFU) were counted and species were differentiated. Fifteen healthy controls were compared. RESULTS: The @entity3 colony count (CFU/ml) at baseline, 0 Grays radiation ranged from 50 to 1820 CFU/ml in cases and from 0 to 300 CFU/ml in controls. @entity3 was seen in all cases (100%) and most of the controls (86.66%). Other species such as C. Krusei, @entity5 , @entity6 , and @entity4 were observed with a frequency of 10%, 6.66%, 3.33%, and 3.33% respectively in the cases. However, no species other than @entity3 was observed in controls. CONCLUSIONS: Immunosupression of radiation therapy @entity0 led to the development of species other than @entity3 , which is the most prevalent species. Thus it can be inferred that there is emergence of the opportunistic fungal pathogens in @entity0 with immunosupression.

title: An assessment of candidal colonization and species differentiation in XXXX @entity0 receiving radiation.

answer: @entity2


abstract: BACKGROUND: Oral colonization with Candida species has been observed in upto 93% of @entity0 receiving radiation for @entity2 . With immunosuppression there is a trend of emergence of rare species. The present study aimed to assess species and colonization of candida at different stages of radiation therapy for @entity2 . METHODS: Oral rinses of thirty @entity1 @entity0 receiving a six weeks course of radiation therapy for @entity2 were taken at two intervals; first at the start of radiation (0 Grays), and second at completion of radiation (60 Grays). The oral rinse was streaked onto a differential media (CHROMagar  ) plates and incubated at 37  C for 48 hours. Colony forming units (CFU) were counted and species were differentiated. Fifteen healthy controls were compared. RESULTS: The @entity3 colony count (CFU/ml) at baseline, 0 Grays radiation ranged from 50 to 1820 CFU/ml in cases and from 0 to 300 CFU/ml in controls. @entity3 was seen in all cases (100%) and most of the controls (86.66%). Other species such as C. Krusei, @entity5 , @entity6 , and @entity4 were observed with a frequency of 10%, 6.66%, 3.33%, and 3.33% respectively in the cases. However, no species other than @entity3 was observed in controls. CONCLUSIONS: Immunosupression of radiation therapy @entity0 led to the development of species other than @entity3 , which is the most prevalent species. Thus it can be inferred that there is emergence of the opportunistic fungal pathogens in @entity0 with immunosupression.

title: An assessment of candidal colonization and species differentiation in @entity2 XXXX receiving radiation.

answer: @entity0


abstract: OBJECTIVES: In @entity3 , a follow-up biopsy taken 1 year after diagnosis is considered important in monitoring histological recovery. In many cases, recovery is incomplete, and the clinical significance of this is poorly understood. We now investigated associated factors and the significance of imperfect histological recovery in @entity0 in whom the follow-up had been completed. METHODS: Two hundred sixty-three biopsy-proven @entity0 were divided into two groups: histological recovery and incomplete recovery after 1 year on gluten-free diet. Serology, laboratory values, bone mineral density, and different clinical variables were measured at diagnosis and after 1 year. Gastrointestinal symptoms and quality of life were assessed by validated questionnaires. Further, long-term follow-up data on mortality, @entity1 , and other severe complications were collected. RESULTS: The incomplete recovery group had more severe @entity2 (P=0.003), higher antibody values (P=0.017), and more signs of @entity4 (P<0.001) at diagnosis. There was no difference in gender, symptoms or quality of life, family history of @entity3 , or comorbidities. At follow-up, there was still a difference in antibodies (P=0.018) and femoral T-scores (P=0.024). Histologically recovered @entity0 showed better dietary adherence, although it was excellent in both groups (97% vs. 87%, P<0.001). There was no difference in long-term outcomes between groups. CONCLUSIONS: The presence of more severe disease in terms of histology, serology, and signs of @entity4 was associated with histological non-response. In @entity0 with high dietary adherence, incomplete villous recovery after 1 year does not affect the clinical response or long-term prognosis. A personalized approach is required to decide the optimal timing of the follow-up biopsy.

title: Predictors and Significance of Incomplete Mucosal Recovery in XXXX After 1 Year on a Gluten-Free Diet.

answer: @entity3