abstract: AIM: This cross-sectional study investigates the relationship between motor performance and mental health in a representative population of @entity0 with @entity1 . METHOD: Ninety-three pupils (45 males, 48 females) aged 6  years to 16  years (mean 11y 3mo, SD 2y 9mo) with @entity1 of at least 40dB and a Nonverbal IQ greater than 70 were assessed for motor performance with the Z  rich Neuromotor Assessment (ZNA) and for mental health with the parent version of the Strengths and Difficulties Questionnaire (SDQ). RESULTS: @entity0 with @entity1 had lower motor performance scores in all four ZNA subscales compared with ZNA norms (z-scores -1.42 to -2.67). After controlling for Nonverbal IQ, ZNA pure motor performance correlated negatively with the SDQ total difficulties score. Pure motor, pegboard, and dynamic balance subscales correlated negatively with peer-relationship problems. Dynamic balance correlated negatively with emotional problems. Performance in pure motor and dynamic balance skills correlated negatively with age. Except for static balance, no correlation was found between motor performance and the degree of @entity1 . INTERPRETATION: Results confirm that a high percentage of @entity0 with @entity1 have poor motor performance. These problems are associated with difficulties in social relationships. Early recognition of these problems may lead to interventions to assist @entity0 with @entity1 with their peer relationships.

title: Motor performance and correlates of mental health in XXXX who are deaf or hard of hearing.

answer: @entity0


abstract: Minimal short-term benefits with oral @entity2 have been reported in @entity1 . We examined long-term oral @entity2 therapy in 14 @entity0 with probable @entity1 in an extended double-blind crossover trial in which they received @entity2 for five intervals of 4 to 6 weeks in length and placebo for one interval determined at random. At each interval a Selective Reminding Test was administered and three indexes were examined: total recall, long-term recall, and intrusions. As a group, @entity0 ' memory test scores were significantly better during the drug period. Two @entity0 who previously had performed worse on drug than on placebo in a short-term trial continued to do so. Nine of the remaining 12 @entity0 performed better on two or more measures on @entity2 compared with placebo. In some cases scores improved up to 50% over placebo values. This improvement was not predicted by response to medication in the earlier short-term trial. Seven @entity0 completed an additional six-interval crossover trial. All but one continued to have improved performance with oral @entity2 and, in grouped data, memory measures remained significantly improved. These results suggest that long-term administration of @entity2 in @entity1 may be more effective than short-term. This benefit can be sustained for up to a year in some @entity0 .

title: Long-term administration of oral XXXX in @entity1 .

answer: @entity2


abstract: Minimal short-term benefits with oral @entity2 have been reported in @entity1 . We examined long-term oral @entity2 therapy in 14 @entity0 with probable @entity1 in an extended double-blind crossover trial in which they received @entity2 for five intervals of 4 to 6 weeks in length and placebo for one interval determined at random. At each interval a Selective Reminding Test was administered and three indexes were examined: total recall, long-term recall, and intrusions. As a group, @entity0 ' memory test scores were significantly better during the drug period. Two @entity0 who previously had performed worse on drug than on placebo in a short-term trial continued to do so. Nine of the remaining 12 @entity0 performed better on two or more measures on @entity2 compared with placebo. In some cases scores improved up to 50% over placebo values. This improvement was not predicted by response to medication in the earlier short-term trial. Seven @entity0 completed an additional six-interval crossover trial. All but one continued to have improved performance with oral @entity2 and, in grouped data, memory measures remained significantly improved. These results suggest that long-term administration of @entity2 in @entity1 may be more effective than short-term. This benefit can be sustained for up to a year in some @entity0 .

title: Long-term administration of oral @entity2 in XXXX .

answer: @entity1


abstract: UNASSIGNED: In @entity4 such as @entity1 ( @entity1 ), regulatory T cells (Tregs) fail to constrain @entity0 ; however, the reasons for this are unclear. We investigated T cell regulation in the @entity1 joint. Tregs from @entity1 synovial fluid suppressed autologous responder T cells; however, when compared with Tregs from healthy control peripheral blood, they were significantly less suppressive. Despite their reduced suppressive activity, Tregs in the @entity1 joint were highly proliferative and expressed @entity2 , @entity7 , and @entity6 , which are markers of functional Tregs. This suggested that the reduced suppression is due to resistance of @entity1 synovial fluid responder T cells to Treg inhibition. @entity8 (+) Th17 lineage cells were significantly enriched in the @entity1 joint; we therefore investigated their relative susceptibility to Treg-mediated suppression. Peripheral blood @entity8 (+) Th cells from healthy controls were significantly more resistant to Treg-mediated suppression, when compared with @entity8 (-) Th cells, and this was mediated through a @entity5 -dependant mechanism. Furthermore, depletion of @entity8 (+) Th cells from the responder T cell population in @entity1 synovial fluid restored Treg-mediated suppression. In addition, @entity8 (+) Th cells exhibited pathogenic features, including polyfunctional proinflammatory cytokine production, an ability to activate synovial fibroblasts, and to survive and persist in the inflamed and @entity3 joint. Because @entity8 (+) Th cells are known to be enriched at sites of autoinflammation, our finding that they are highly proinflammatory and resistant to Treg-mediated suppression suggests an important pathogenic role in @entity1 and other @entity4 .

title: Polyfunctional, Pathogenic XXXX + Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity.

answer: @entity8


abstract: BACKGROUND: Tumor resection in non-metastatic @entity2 ( @entity2 ) @entity0 with adequate liver reserve offers a potential cure, but has a high 5-year recurrence rate. We analyzed the patterns of @entity1 relapse after partial hepatectomy to guide post-operative management. METHODS: A total of 144 @entity2 @entity0 (1996-2011) after partial hepatectomy were reviewed. Statistical correlations were determined using univariate and partition analyses. RESULTS: A median follow-up of 20 months showed recurrence in 71 (49%) @entity0 , and the median time to recurrence was 11.9 months. Vascular invasion (P<0.01) and number of lesions (P<0.01) predicted for recurrence. Histologic grade was not correlated with recurrence. Twenty-two (31%) @entity0 developed both surgical margin (SM) and concurrent intrahepatic recurrences, and 28 (40%) had non-SM intrahepatic recurrences with no other signs of recurrence. On partition analysis, the risk of marginal recurrence in @entity0 with SM <1 mm and SM >= 1 mm was 35% and 13.5% respectively. Approximately 57% of @entity0 with intrahepatic recurrence had recurrence  <=2.5 cm from SM. CONCLUSIONS: Intrahepatic recurrence after partial hepatectomy is common and is significantly associated with vascular invasion and @entity1 stage. About 57% of @entity0 with intrahepatic relapse had a recurrence close ( <=2.5 cm) to the SM. Additionally, @entity0 with SM <1 mm have a higher recurrence rate and may benefit from adjuvant local therapy.

title: Patterns of XXXX recurrence in localized resected @entity2 .

answer: @entity1


abstract: BACKGROUND: Tumor resection in non-metastatic @entity2 ( @entity2 ) @entity0 with adequate liver reserve offers a potential cure, but has a high 5-year recurrence rate. We analyzed the patterns of @entity1 relapse after partial hepatectomy to guide post-operative management. METHODS: A total of 144 @entity2 @entity0 (1996-2011) after partial hepatectomy were reviewed. Statistical correlations were determined using univariate and partition analyses. RESULTS: A median follow-up of 20 months showed recurrence in 71 (49%) @entity0 , and the median time to recurrence was 11.9 months. Vascular invasion (P<0.01) and number of lesions (P<0.01) predicted for recurrence. Histologic grade was not correlated with recurrence. Twenty-two (31%) @entity0 developed both surgical margin (SM) and concurrent intrahepatic recurrences, and 28 (40%) had non-SM intrahepatic recurrences with no other signs of recurrence. On partition analysis, the risk of marginal recurrence in @entity0 with SM <1 mm and SM >= 1 mm was 35% and 13.5% respectively. Approximately 57% of @entity0 with intrahepatic recurrence had recurrence  <=2.5 cm from SM. CONCLUSIONS: Intrahepatic recurrence after partial hepatectomy is common and is significantly associated with vascular invasion and @entity1 stage. About 57% of @entity0 with intrahepatic relapse had a recurrence close ( <=2.5 cm) to the SM. Additionally, @entity0 with SM <1 mm have a higher recurrence rate and may benefit from adjuvant local therapy.

title: Patterns of @entity1 recurrence in localized resected XXXX .

answer: @entity2


abstract: BACKGROUND: Magnetic resonance enterography (MRE) can measure small bowel motility, reduction in which reflects inflammatory burden in @entity1 ( @entity1 ). However, it is unknown if motility improves with successful treatment. AIM: To determine if changes in segmental small bowel motility reflect response to anti- @entity2 therapy after induction and longer term. METHODS: A total of 46 @entity0 (median 29  years, 19 females) underwent MRE before anti- @entity2 treatment; 35 identified retrospectively underwent repeat MRE after median 55  weeks of treatment and 11 recruited prospectively after median 12  weeks. Therapeutic response was defined by physician global assessment (retrospective group) or a >= 3 point drop in the Harvey-Bradshaw Index (prospective group), @entity3 and the MaRIA score. Two independent radiologists measured motility using an MRE image-registration algorithm. We compared motility changes in responders and nonresponders using the Mann-Whitney test. RESULTS: Anti- @entity2 responders had significantly greater improvements in motility (median  =  73.4% increase from baseline) than nonresponders (median  =  25% reduction, P  <  0.001). Improved MRI-measured motility was 93.1% sensitive (95%CI: 78.0-98.1%) and 76.5% specific (95% CI: 52.7-90.4%) for anti- @entity2 response. @entity0 with @entity3 normalisation (<5  mg/L) had significantly greater improvements in motility (median  =  73.4% increase) than those with persistently elevated @entity3 (median  =  5.1%, P  =  0.035). Individuals with post-treatment MaRIA scores of <11 had greater motility improvements (median  =  94.7% increase) than those with post-treatment MaRIA score >11 (median 15.2% increase, P  =  0.017). CONCLUSIONS: Improved MRI-measured small bowel motility accurately detects response to anti- @entity2 therapy for @entity1 , even as early as 12  weeks. Motility MRI may permit early identification of nonresponse to anti- @entity2 agents, allowing personalised treatment.

title: Magnetic resonance imaging-quantified small bowel motility is a sensitive marker of response to medical therapy in XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the efficacy and safety of @entity2 in adolescents with primary @entity1 . METHODS: This 52-week, multicenter, nonrandomized, open-label study was conducted in 141 adolescents ages 12 to 17 years with severe primary @entity1 . @entity0 could receive up to six treatments with @entity2 (50  U per axilla), with re-treatment occurring no sooner than 8  weeks after the prior treatment cycle and no later than 44  weeks after the initial treatment cycle. The primary efficacy measure was treatment response, based on self-assessed @entity1 severity following the first two treatments using the 4-point @entity1 Severity Scale (HDSS). Other efficacy measures included spontaneous resting sweat production and health outcomes. RESULTS: Fifty-six (38.9%) @entity0 underwent one treatment, 59 (41.0%) underwent two, 20 (13.9%) underwent three, 6 (4.2%) underwent four, and 3 (2.1%) underwent five. @entity2 significantly improved HDSS scores and decreased sweat production compared with treatment cycle baselines. Seventy-nine @entity0 (54.9%) responded to treatment based on HDSS criteria. From 56.6% to 72.3% of @entity0 experienced a two-grade or more improvement at 4 and 8  weeks after each of the first two treatments. The majority (79.4%-93.2%) had a 75% or greater reduction in sweat production at week 4 (treatments 1-3). The median duration of effect for responders ranged from 134 to 152  days. Using quality of life measures, health outcomes improved markedly. Eight @entity0 (5.6%) had mild or moderate treatment-related adverse events. No unexpected safety signals were observed in this study. Neutralizing antibodies to @entity2 did not develop. CONCLUSION: @entity2 injections provided beneficial effects in adolescents with primary @entity1 .

title: A Prospective, Nonrandomized, Open-Label Study of the Efficacy and Safety of @entity2 in Adolescents with Primary XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the efficacy and safety of @entity2 in adolescents with primary @entity1 . METHODS: This 52-week, multicenter, nonrandomized, open-label study was conducted in 141 adolescents ages 12 to 17 years with severe primary @entity1 . @entity0 could receive up to six treatments with @entity2 (50  U per axilla), with re-treatment occurring no sooner than 8  weeks after the prior treatment cycle and no later than 44  weeks after the initial treatment cycle. The primary efficacy measure was treatment response, based on self-assessed @entity1 severity following the first two treatments using the 4-point @entity1 Severity Scale (HDSS). Other efficacy measures included spontaneous resting sweat production and health outcomes. RESULTS: Fifty-six (38.9%) @entity0 underwent one treatment, 59 (41.0%) underwent two, 20 (13.9%) underwent three, 6 (4.2%) underwent four, and 3 (2.1%) underwent five. @entity2 significantly improved HDSS scores and decreased sweat production compared with treatment cycle baselines. Seventy-nine @entity0 (54.9%) responded to treatment based on HDSS criteria. From 56.6% to 72.3% of @entity0 experienced a two-grade or more improvement at 4 and 8  weeks after each of the first two treatments. The majority (79.4%-93.2%) had a 75% or greater reduction in sweat production at week 4 (treatments 1-3). The median duration of effect for responders ranged from 134 to 152  days. Using quality of life measures, health outcomes improved markedly. Eight @entity0 (5.6%) had mild or moderate treatment-related adverse events. No unexpected safety signals were observed in this study. Neutralizing antibodies to @entity2 did not develop. CONCLUSION: @entity2 injections provided beneficial effects in adolescents with primary @entity1 .

title: A Prospective, Nonrandomized, Open-Label Study of the Efficacy and Safety of XXXX in Adolescents with Primary @entity1 .

answer: @entity2


abstract: BACKGROUND: Implants have been widely used to restore missing teeth. Limited information on applied anatomy at the anterior maxilla compromises the clinical outcome for implant placement in this region. In the current study, Cone Beam Computerized Tomography (CBCT) was used to measure @entity0 and buccal undercut dimension at the anterior maxilla to help develop treatment planning for immediate implant placement. METHODS: CBCT scans were screened to include 51 subjects with full dentition at @entity4 . Measurements were taken at the cross sectional views in the middle of the maxillary right central incisor, lateral incisor, and @entity1 regions. Alveolar height was measured from the alveolar crest to floor of nasal fossa. Alveolar width was measured from the buccal to palatal cortical plate at the coronal, middle, and apical third of the distance from the alveolar crest to floor of the nasal fossa. Buccal undercut location was measured from where the buccal cortical plate started dipping to a line extending at the alveolar crest that was perpendicular to the long axis of the @entity0 . The buccal undercut depth was measured from the deepest point of the undercut at the buccal plate to a line tangent to the buccal plate paralleling the long axis of ridge. RESULTS: Alveolar width increased from coronal to apical direction for each tooth. Mean alveolar widths (mm) were: central incisor, 9.55; lateral incisor, 8.30; @entity1 , 9.62. The lateral incisor had a significantly smaller alveolar width than the other anterior teeth. No significant difference in ridge height was noted among the teeth. Undercut locations from the alveolar crest (mm) were: central incisor, 5.84; lateral incisor, 3.59; @entity1 , 5.11. Undercut depths (mm) were: central incisor, 0.76; lateral incisor, 0.87; @entity1 , 0.73. The percentages of teeth with buccal undercuts were: central incisor, 41%, lateral incisor, 77%, and @entity1 33%. Male demonstrate significant larger ridge width compared with females for all three teeth. CONCLUSIONS: At anterior maxilla, the lateral incisor has the @entity2 , and most frequently exhibits a buccal undercut which is the closest to @entity0 compared with other @entity3 .

title: Anterior maxilla XXXX dimension and morphology measurement by cone beam computerized tomography (CBCT) for immediate implant treatment planning.

answer: @entity0


abstract: OBJECTIVES: The purpose of this study was to determine the effect of the @entity3 antifungals on the cardiac system, including @entity1 , blood pressure and heart rate, when administered in an in-vivo model. METHODS: The @entity3 antifungals were administered via central line to male @entity0 . Cardiac imaging and functional measurements were made using a high-resolution in-vivo imaging system. Statistical comparisons of the experimental antifungals versus saline control were made using a Student's t-test. KEY FINDINGS: In @entity1 (CO) measurements, @entity4 was associated with a bimodal distribution in results at 3   mg/kg. Those with little response, termed 'non-vulnerable' animals (n   =   3) had no significant change in CO from baseline (-4.6        10.7%). Other animals, termed 'vulnerable' animals (n   =   3 at 3   mg/kg and those dosed at 6   mg/kg (n   =   6)), experienced greater than 60% decrease in CO (-66.4        13.1% at 3   mg/kg and -62.9        13.0% at 6   mg/kg, P   <   0.05). A dose of 5   mg/kg @entity5 was associated with no significant changes in CO (-16.1        26%), while 11.5   mg/kg decreased CO by 62.7        19.4% from baseline (P   <   0.05). With @entity2 1   mg/kg and 5   mg/kg doses, changes in CO were not significant (-16.7        2.1% and -18.2        1.9%, respectively). CONCLUSIONS: These studies provide substantial evidence to support ex-vivo Langendorff and in-vitro mitochondrial studies demonstrating a similar pharmacological event. Clinical reports of similar effects also support these findings.

title: Cardiac response to centrally administered XXXX antifungals.

answer: @entity3


abstract: The effects of feeding frequency and diet composition on mammary arteriovenous (AV) differences were observed in lactating dairy @entity0 . Two diets with 30 or 70 p. 100 concentrate (table 1) were offered 2 or 8 times daily in limited amounts. Circadian patterns of mammary AV differences in the main blood metabolites and in milk production (table 2) were studied in two @entity0 with an exteriorized carotid. Diet digestibility and ruminal fermentation profiles were studied in two other @entity0 fitted with a rumen cannula (tables 3, 4). 1. Circadian patterns of arterial levels and AV differences in @entity2 and @entity4 depended on feeding frequency (fig. 2). With two feedings per day, the arterial levels reached a maximum 4 or 5 hrs after feeding, and the circadian patterns of AV differences were strongly related to those of the arterial levels. With 8 feedings per day, the circadian changes in AV differences were smaller (fig. 2), and their coefficients of variation decreased from 13 to 9 p. 100. On the other hand, packed cell volume and arterial @entity1 did not show any noticeable circadian changes, even with 2 feedings per day. 2. The mean arterial levels and AV differences in @entity2 , @entity4 and most of the essential @entity3 (EAA) decreased (-16, -8 and -10 p. 100) (table 5) when the feeding times were increased from 2 to 8 per day. The EAA decreased more with the high concentrate (-19 p. 100) than with the low concentrate (-8 p. 100) diet (table 6). 3. With the "high concentrate" diet, the arterial levels and AV differences in @entity2 were lower (-25 p. 100), while those of @entity4 were higher (+13 p. 100), although the ruminal fermentations were not very different. "Continuous feeding" stabilized the AV differences, thus permitting the number of blood samples required to be reduced (50 p. 100). But this technique caused some physiological modifications, and the results obtained are not applicable to the standard practice of two feedings per day.

title: [Methodological study on measuring mammary arteriovenous differences in the dairy XXXX ].

answer: @entity0


abstract: OBJECTIVES: To clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of @entity3 using preliminary clinical data. MATERIALS AND METHODS: Between November 2012 and March 2014, MRE was applied to all @entity0 who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation of liver tissue within 3  months from MR examinations were retrospectively recruited, and the @entity2 measured by MRE was correlated with histological results. Institutional review board approved this study, waiving informed consent. RESULTS: There were 70 @entity0 who met the inclusion criteria. Liver stiffness showed significant correlation with the pathological grades of @entity3 (rho   =   0.89, p   <   0.0001, Spearman's rank correlation). Areas under the receiver operating characteristic curve were 0.93, 0.95, 0.99 and 0.95 for @entity1 score greater than or equal to F1, F2, F3 and F4, with cut-off values of 3.13, 3.85, 4.28 and 5.38  kPa, respectively. Multivariate analysis suggested that grades of necroinflammation also affected @entity2 , but to a significantly lesser degree as compared to @entity1 . CONCLUSIONS: 3.0-T clinical MRE was suggested to be sufficiently useful in assessing the grades of @entity3 . KEY POINTS:     MR elastography may help clinicians assess @entity0 with chronic @entity2     Usefulness of 3.0-T MR elastography has rarely been reported     Measured @entity2 correlated well with the histological grades of @entity3     Measured @entity2 was also affected by necroinflammation, but to a lesser degree     3.0-T MRE could be a non-invasive alternative to liver biopsy.

title: MR elastography of the liver at 3.0 T in diagnosing XXXX grades; preliminary clinical experience.

answer: @entity3


abstract: From 1972 to 1984, 104 cases of aortic valve @entity2 were treated surgically. The average age of the @entity0 was 40 years and the majority were @entity0 (69/104). Forty @entity0 had no previous @entity4 ; 44 @entity0 had documented @entity5 , which was unlikely in the remaining 20 @entity0 . There were 16 mitral valve, 55 aortic valve, 1 tricuspid, 30 mitro-aortic, 1 mitro-tricuspid and 1 mitro-aorto-tricuspid valve infections. Aerococcus viridans was isolated in only 4 out of 71 positive cultures: the prevalence of the infecting organisms was otherwise normal (30 staphylococcus, 30 streptococcus, 7 rare organisms). Forty one @entity0 were operated because of @entity8 , 13 for @entity3 and 13 for an association of both indications; 37 @entity0 were operated for @entity7 or threatening vegetations. Eight @entity0 were in functional Class I, 26 in Class II, 52 in Class III and 17 in Class IV. The @entity0 were divided into 4 groups according to the degree of surgical emergency (26 extremely urgent, 26 semi urgent, 32 controlled @entity6 and 20 @entity1 ). The actuarial survival rate was 70% at 5 years. Poor prognostic factors were the presence of previous @entity5 , the isolation of a staphylococcus and an aortic valve localisation. The degree of emergency and the precise surgical indication did not seem to be important. Most @entity0 at long term were in functional Classes I or II. There was no preferential indication for bioprosthetic or mechanical valve replacement in @entity6 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Indications and results of surgery in native valve XXXX . Apropos of 104 surgically-treated cases].

answer: @entity2


abstract: BACKGROUND: The infection of @entity1 ( @entity1 ) is one of the most important causes of @entity2 . The role of @entity3 ( @entity4 ) production in @entity1 -induced @entity2 . AIM: The expression of @entity5 -y-lyase (CSE) was determined, and correlated with the severity of @entity2 . METHODS: One hundred and eight @entity0 were selected based on the determination of @entity2 and the infection of @entity1 ( @entity1 ), including 36 normal control, 36 @entity0 with @entity1 -negative @entity2 , and 36 @entity0 with @entity1 -positive @entity2 . RT-PCR determination was performed to determine the expression of CSE, NF-kB and IL-8. RESULTS: The expression of CSE, NF-kB and IL-8 was higher in the @entity2 group than control group (p<0.05). Compared with the @entity1 -negative @entity2 , the expression of CSE, NF-kB and IL-8 was higher than @entity1 -positive @entity2 group (p<0.05). For @entity1 -negative @entity2 group, the expression of CSE positively correlated with the expression of NF-kB (r=0.98, p<0.05) and IL-8 (r=0.95, p<0.05). For @entity1 -positive @entity2 group, the expression of CSE also positively correlated with the expression of NF-kB (r=0.99, p<0.05) and IL-8 (r=0.85, p<0.05). CONCLUSION: The expression of CSE was positively correlated with the severity of @entity2 .

title: Correlation between the XXXX -r-lyase (CES) and the severity of peptic ulcer disease.

answer: @entity5


abstract: The tissue levels of @entity3 ( @entity3 ) in endomyocardial biopsy samples and blood from 43 @entity0 with @entity1 were determined by steps of extraction, purification, and HPLC. The biopsy samples were obtained from the @entity0 after a routine heart catheterization. Six @entity0 were of class I, 18 of class II, 11 of class III, and 8 of class IV (classified according to guidelines of the New York Heart Association). True control biopsies of healthy hearts are not available for ethical reasons, but the data of the four classes by severity of disease may be justifiably compared. @entity0 of class IV had lower (P less than 0.01) levels of @entity3 than those of class I. @entity0 of classes III and IV had a lower (P less than 0.0001) level than those of classes I and II. Biopsy samples were obtained from five @entity0 after treatment with @entity3 for 2-8 months. The increases of @entity3 levels ranged from 20% to 85%; the mean value was higher (P less than 0.02) than before treatment. @entity2 also increase with severity of disease, but not as markedly as for the biopsies. These data reveal a @entity1 of @entity3 , which is higher with increasing severity of disease and is reduced by therapy. This biochemistry correlates with the effective treatment of @entity1 with @entity3 .

title: Biochemical rationale and myocardial tissue data on the effective therapy of XXXX with coenzyme Q10.

answer: @entity1


abstract: @entity16 ( @entity16 ), a new lipid-soluble antitumor agent, was given by 15-30-minute infusion on a daily X 5 schedule to 47 @entity0 with refractory @entity1 and @entity8 . The starting daily dose of 6 mg/m2 was escalated to 10 and 35 mg/m2 in @entity0 with @entity1 and @entity8 , respectively. In @entity0 with @entity1 , myelosuppression was dose-limiting at a daily dose of 10 mg/m2. In @entity0 with @entity8 , prolonged @entity11 and @entity2 were observed at daily doses greater than or equal to 25 mg/m2. At these higher doses, significant @entity13 associated with @entity3 was also seen. Corresponding increases of transaminases or alkaline phosphatase and significant @entity9 were not noted. The maximum tolerated dose for this daily dose schedule was 9 mg/m2 in @entity0 with @entity1 and 25 mg/m2 in @entity0 with relapsed @entity8 . Responses to @entity16 included stabilization of disease in @entity4 , @entity14 , @entity6 , and @entity5 . A @entity0 with juvenile chronic @entity10 in @entity15 converted back to the chronic phase. A @entity0 with @entity7 had a substantial decrease in cerebrospinal fluid blast count. @entity2 was achieved in @entity0 with @entity7 and @entity12 ; however, remissions were not achieved. A phase II study of @entity16 in @entity0 with @entity1 is now being performed by the Childrens Cancer Study Group.

title: Phase I clinical evaluation of @entity16 in childhood XXXX .

answer: @entity1


abstract: @entity16 ( @entity16 ), a new lipid-soluble antitumor agent, was given by 15-30-minute infusion on a daily X 5 schedule to 47 @entity0 with refractory @entity1 and @entity8 . The starting daily dose of 6 mg/m2 was escalated to 10 and 35 mg/m2 in @entity0 with @entity1 and @entity8 , respectively. In @entity0 with @entity1 , myelosuppression was dose-limiting at a daily dose of 10 mg/m2. In @entity0 with @entity8 , prolonged @entity11 and @entity2 were observed at daily doses greater than or equal to 25 mg/m2. At these higher doses, significant @entity13 associated with @entity3 was also seen. Corresponding increases of transaminases or alkaline phosphatase and significant @entity9 were not noted. The maximum tolerated dose for this daily dose schedule was 9 mg/m2 in @entity0 with @entity1 and 25 mg/m2 in @entity0 with relapsed @entity8 . Responses to @entity16 included stabilization of disease in @entity4 , @entity14 , @entity6 , and @entity5 . A @entity0 with juvenile chronic @entity10 in @entity15 converted back to the chronic phase. A @entity0 with @entity7 had a substantial decrease in cerebrospinal fluid blast count. @entity2 was achieved in @entity0 with @entity7 and @entity12 ; however, remissions were not achieved. A phase II study of @entity16 in @entity0 with @entity1 is now being performed by the Childrens Cancer Study Group.

title: Phase I clinical evaluation of XXXX in childhood @entity1 .

answer: @entity16


abstract: Oral administration of @entity7 has been reported to prevent gut disease in @entity0 @entity0 . However, little is known about the effects of dietary @entity1 supplementation on intestinal development of weaned piglets. In the present study, twenty 21-d-old castrated piglets with 5  3 (SEM 0  13) kg body weight (BW) were weaned from sows, individually housed and randomly assigned to one of the two @entity5 - and soyabean meal-based diets supplemented with 0 or 1% @entity7 . After consuming the diets for 7 d, six @entity4 were randomly selected from each group to obtain various tissues. Compared with control @entity4 , dietary supplementation with 1% @entity7 did not affect feed intake but enhanced (P<0  05) the relative weight of the small intestine (+33 %), daily BW gain (+38 %) and feed efficiency (+28 %). The villus height of the duodenum, jejunum and ileum in @entity1 -supplemented piglets was 21, 28 and 25% greater (P<0  05) than in the nonsupplemented control group. @entity1 supplementation increased (P<0  05) protein levels for vascular endothelial growth factor( @entity8 ) in duodenal, jejunal and ileal mucosae by 14, 39 and 35 %, respectively. Compared with the control group, dietary supplementation with 1% @entity7 increased (P<0  05) plasma concentrations of @entity1 and insulin (+36 %), and decreased (P<0  05) plasma concentrations of @entity2 (233 %), @entity6 (221 %) and @entity3 (219 %). These results indicate that @entity1 supplementation enhances intestinal growth, development and expression of @entity8 in early-weaned @entity4 fed a @entity5 - and soyabean meal-based diet. The findings may have important implications for neonatal @entity4 under stressful or diseased conditions.

title: Dietary XXXX supplementation enhances intestinal development and expression of vascular endothelial growth factor in weanling piglets.

answer: @entity7


abstract: Two experiments were conducted to examine the prolonged behavioral effects of perinatal exposure to @entity1 ( @entity1 , @entity3 ) in @entity0 . Experiment I involved testing a group of three monkeys whose mothers had been fed 2.5 ppm @entity1 in their diets both before and throughout gestation and nursing (concurrent exposure condition), and a group of three control monkeys whose mothers had received no added dietary @entity1 . These offspring began testing at approximately 60 months of age. In experiment II the same group of female breeders which were fed @entity1 in experiment I underwent a second round of breeding after being off the contaminated diet for an average of 20 months (postexposure condition). Additionally, another group of female monkeys underwent breeding while receiving concurrent exposure to 0.5 ppm @entity1 in their diet. Control female monkeys received no added dietary @entity1 . Four offspring from the 2.5 ppm postexposure condition, four from the 0.5 ppm concurrent exposure condition and five control offspring survived to begin testing here at approximately 40 months of age. All monkeys from experiments I and II were tested under a series of fixed-interval schedules of food reinforcement consisting of FI 30 sec (10 sessions) and FI 60, 300 and 600 sec (15 sessions each). Performance measures included overall response rate, index of curvature (IC) and postreinforcement pause (PRP). There were no consistent differences in FI performance between @entity2 and respective control groups except for a slightly though significantly lower IC in the @entity2 groups of experiment II under FI 300 and 600.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Behavioral evaluation of perinatal XXXX exposure in @entity0 : fixed-interval performance and reinforcement-omission.

answer: @entity2


abstract: Two experiments were conducted to examine the prolonged behavioral effects of perinatal exposure to @entity1 ( @entity1 , @entity3 ) in @entity0 . Experiment I involved testing a group of three monkeys whose mothers had been fed 2.5 ppm @entity1 in their diets both before and throughout gestation and nursing (concurrent exposure condition), and a group of three control monkeys whose mothers had received no added dietary @entity1 . These offspring began testing at approximately 60 months of age. In experiment II the same group of female breeders which were fed @entity1 in experiment I underwent a second round of breeding after being off the contaminated diet for an average of 20 months (postexposure condition). Additionally, another group of female monkeys underwent breeding while receiving concurrent exposure to 0.5 ppm @entity1 in their diet. Control female monkeys received no added dietary @entity1 . Four offspring from the 2.5 ppm postexposure condition, four from the 0.5 ppm concurrent exposure condition and five control offspring survived to begin testing here at approximately 40 months of age. All monkeys from experiments I and II were tested under a series of fixed-interval schedules of food reinforcement consisting of FI 30 sec (10 sessions) and FI 60, 300 and 600 sec (15 sessions each). Performance measures included overall response rate, index of curvature (IC) and postreinforcement pause (PRP). There were no consistent differences in FI performance between @entity2 and respective control groups except for a slightly though significantly lower IC in the @entity2 groups of experiment II under FI 300 and 600.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Behavioral evaluation of perinatal @entity2 exposure in XXXX : fixed-interval performance and reinforcement-omission.

answer: @entity0


abstract: BACKGROUND AND OBJECTIVE: Lung transplantation is an efficient therapeutic option for @entity0 with end-stage @entity6 , but less is known about @entity1 after lung transplantation. The aim of this study is to improve the awareness, diagnosis and treatment of @entity4 after lung transplantation with a case report and related literatures. METHODS: We reported a 65-year-old male with @entity12 ( @entity12 ) who underwent right lung transplantation under extracorporeal membrane oxygenation (ECMO) support in May 2007 in our hospital. The @entity0 recovered smoothly and discharged from the hospital 46 days after the procedure with regular follow-up. Immunosuppression therapy was triple drug maintenance regimen including @entity10 (Tac), @entity7 ( @entity11 ) and @entity5 . RESULTS: @entity3 in the left lung with multiple osseous @entity2 was found 13 months after the lung transplantation. Symptoms were relieved a bit by administering chemotherapeutics ( @entity13 and @entity8 ) for 4 cycles. However, the @entity0 was succumbed to his illness within 11 months after the diagnosis of @entity1 . CONCLUSIONS: @entity1 after lung transplantation has been suggested as one of causes of late mortality with the risk factors such as @entity9 ( @entity9 ), @entity12 , cigarette smoking history and immunosuppression etc. Early diagnosis and treatment are very important to improve the prognosis.

title: [ XXXX after lung transplantation: a case report and literature review].

answer: @entity4


abstract: Dynamic exercise evokes sustained blood pressure and heart rate (HR) increases. Although it is well accepted that there is a CNS mediation of cardiovascular adjustments during dynamic exercise, information on the role of specific CNS structures is still limited. The bed nucleus of the stria terminalis (BST) is involved in exercise-evoked cardiovascular responses in @entity0 . However, the specific neurotransmitter involved in BST-related modulation of cardiovascular responses to dynamic exercise is still unclear. In the present study, we investigated the role of local BST adrenoceptors in the cardiovascular responses evoked when @entity0 are submitted to an acute bout of exercise on a rodent treadmill. We observed that bilateral microinjection of the selective a1-adrenoceptor antagonist @entity2 into the BST enhanced the HR increase evoked by dynamic exercise without affecting the mean arterial pressure (MAP) increase. Bilateral microinjection of the selective a2-adrenoceptor antagonist @entity3 reduced exercise-evoked pressor response without changing the tachycardiac response. BST pretreatment with the nonselective b-adrenoceptor antagonist @entity1 did not affect exercise-related cardiovascular responses. BST treatment with either @entity2 or @entity3 did not affect motor performance in the open-field test, which indicates that effects of BST adrenoceptor antagonism in exercise-evoked cardiovascular responses were not due to changes in motor activity. The present findings are the first evidence showing the involvement of CNS adrenoceptors in cardiovascular responses during dynamic exercise. Our results indicate an inhibitory influence of BST a1-adrenoceptor on the exercise-evoked HR response. Data also point to a facilitatory role played by the activation of BST a2-adrenoceptor on the pressor response to dynamic exercise.

title: Bed nucleus of the stria terminalis a1- and a2-adrenoceptors differentially modulate the cardiovascular responses to exercise in XXXX .

answer: @entity0


abstract: Both @entity3 and @entity4 @entity4 ( @entity4 ) are induced by the administration of @entity6 in the unilateral @entity5 lesioned @entity1 model of @entity2 . Since rotational responses can be conditioned to environmental cues we have investigated the extent to which drug-induced AIMS may also be conditioned by exteroceptive cues and experience. In Experiment I, @entity5 lesioned @entity1 received repeated daily injections of @entity6 either in their home cage (control) or in association with a brief (20 mins) exposure to the rotometers (paired). To assess conditioning, all animals then received two tests in the rotometer bowls. Following injection of saline the paired group both rotated more contralaterally and displayed manifest @entity4 , neither of which were exhibited by the control @entity1 . Moreover, following injection of @entity6 , the paired group showed a trend for increased @entity4 compared to controls. Two further studies provided longer exposure to the conditioning environments in counterbalanced designs. Although, using these parameters, re-exposure in the presence of saline did not induce context-dependent @entity4 , a strong context-specific component of the sensitised response to @entity6 was seen; chronic administration of drug produced a significantly stronger behavioural response in animals paired with a particular environment for drug administration than controls. This data suggests that part of the sensitisation of behavioural responding to @entity6 administration is not solely a pharmacological phenomenon, but is also conditioned to the environmental context in which the drug is administered. This has clear implications for the clinical observation and experimental measurement of drug-induced @entity4 in @entity2 @entity0 and animal models.

title: Context-driven changes in @entity6 -induced behaviours in the XXXX lesioned @entity1 .

answer: @entity5


abstract: Both @entity3 and @entity4 @entity4 ( @entity4 ) are induced by the administration of @entity6 in the unilateral @entity5 lesioned @entity1 model of @entity2 . Since rotational responses can be conditioned to environmental cues we have investigated the extent to which drug-induced AIMS may also be conditioned by exteroceptive cues and experience. In Experiment I, @entity5 lesioned @entity1 received repeated daily injections of @entity6 either in their home cage (control) or in association with a brief (20 mins) exposure to the rotometers (paired). To assess conditioning, all animals then received two tests in the rotometer bowls. Following injection of saline the paired group both rotated more contralaterally and displayed manifest @entity4 , neither of which were exhibited by the control @entity1 . Moreover, following injection of @entity6 , the paired group showed a trend for increased @entity4 compared to controls. Two further studies provided longer exposure to the conditioning environments in counterbalanced designs. Although, using these parameters, re-exposure in the presence of saline did not induce context-dependent @entity4 , a strong context-specific component of the sensitised response to @entity6 was seen; chronic administration of drug produced a significantly stronger behavioural response in animals paired with a particular environment for drug administration than controls. This data suggests that part of the sensitisation of behavioural responding to @entity6 administration is not solely a pharmacological phenomenon, but is also conditioned to the environmental context in which the drug is administered. This has clear implications for the clinical observation and experimental measurement of drug-induced @entity4 in @entity2 @entity0 and animal models.

title: Context-driven changes in XXXX -induced behaviours in the @entity5 lesioned @entity1 .

answer: @entity6


abstract: Both @entity3 and @entity4 @entity4 ( @entity4 ) are induced by the administration of @entity6 in the unilateral @entity5 lesioned @entity1 model of @entity2 . Since rotational responses can be conditioned to environmental cues we have investigated the extent to which drug-induced AIMS may also be conditioned by exteroceptive cues and experience. In Experiment I, @entity5 lesioned @entity1 received repeated daily injections of @entity6 either in their home cage (control) or in association with a brief (20 mins) exposure to the rotometers (paired). To assess conditioning, all animals then received two tests in the rotometer bowls. Following injection of saline the paired group both rotated more contralaterally and displayed manifest @entity4 , neither of which were exhibited by the control @entity1 . Moreover, following injection of @entity6 , the paired group showed a trend for increased @entity4 compared to controls. Two further studies provided longer exposure to the conditioning environments in counterbalanced designs. Although, using these parameters, re-exposure in the presence of saline did not induce context-dependent @entity4 , a strong context-specific component of the sensitised response to @entity6 was seen; chronic administration of drug produced a significantly stronger behavioural response in animals paired with a particular environment for drug administration than controls. This data suggests that part of the sensitisation of behavioural responding to @entity6 administration is not solely a pharmacological phenomenon, but is also conditioned to the environmental context in which the drug is administered. This has clear implications for the clinical observation and experimental measurement of drug-induced @entity4 in @entity2 @entity0 and animal models.

title: Context-driven changes in @entity6 -induced behaviours in the @entity5 lesioned XXXX .

answer: @entity1


abstract: The effect of @entity4 on transplanted @entity1 pancreatic islets was studied using a new technique for transplanting a defined number of islets in a @entity3 . Normal or @entity2 - @entity0 DA @entity1 were given 400 DA islets under the left kidney capsule (a number shown to be insufficient to reverse @entity0 ). After 2 weeks the @entity0 @entity1 were given a further 1000 islets under the right kidney capsule to reverse @entity0 . Kidneys from both groups were examined at 2 weeks after the initial islet implant and at 3 months for both gross and histological appearance and for insulin content. After 2 weeks left kidneys from nondiabetic @entity1 showed abundant islet tissue, with an insulin content of 116 (+/- 14 SEM) milliunits, compared to 1 +/- 0.5 milliunits in the right kidney. Kidneys from @entity0 @entity1 showed no islets recognizable grossly. Histological examination showed vacuolated tissue scarcely recognizable as islet tissue, and the insulin content of the left kidney was reduced to 18 +/- 5 milliunits. However, 3 months after reversal of @entity0 by transplantation of 1000 islets to the right kidney, histologically "normal" islet tissue was again visible on the left kidney, and the insulin content was 160 +/- 36 milliunits. Islets left in normal animals for 3 months contained 195 +/- 50 milliunits. These experiments show that islets implanted beneath the kidney capsule in @entity0 @entity1 are not destroyed by two weeks @entity4 . This suggests that protection of islets after implantation by insulin treatment is unnecessary, even in the presence of a persistently raised blood sugar.

title: The effect of XXXX on isolated rodent islets transplanted to the kidney capsule site.

answer: @entity4


abstract: PURPOSE: To assess the prognostic value of the Mandard tumour regression score (TRG) following pre-operative chemo/radiotherapy in @entity0 with locally advanced @entity1 . METHODS AND MATERIALS: The study involved 158 @entity0 with locally advanced @entity1 treated with pre-operative long course chemo/radiotherapy at Nottingham University Hospital between April 2001 and December 2008. @entity0 were treated with radiotherapy to a dose of 50 Gy in 25 fractions over 5 weeks with or without concurrent @entity2 chemotherapy at a dose of 1650 mg/m(2)/day. Surgery was normally performed after an interval of 6-10 weeks. The response to pre-operative treatment was carefully graded by a single pathologist using the five point Mandard score. The median follow-up was 40 months (range 3-90 months). RESULTS: Of the 158 @entity0 14% were @entity3 , 41% were @entity4 , 31% were @entity5 , 13% were @entity7 and 1% were @entity6 . The groups were combined into @entity3 , @entity4 and @entity5 -5 to simplify further analysis. The Mandard score was clearly related to both disease-free (p < 0.001) and overall survival (p = 0.012). On multivariate analysis perineural invasion, nodal status, TRG and circumferential resection margin status were the most powerful predictors of disease-free survival. CONCLUSIONS: The Mandard tumour regression score is an independent prognostic factor and predicts for long-term outcome following pre-operative chemo/radiotherapy in @entity1 .

title: Prognostic importance of Mandard tumour regression grade following pre-operative chemo/radiotherapy for locally advanced XXXX .

answer: @entity1


abstract: BACKGROUND: The identification of individuals who are at high risk of @entity3 may lead to earlier detection and diagnosis. In this study, we describe the development and preliminary validation of a very brief, Internet-based risk assessment tool. METHODS: The @entity3 Risk Assessment collected information on demographic, neurologic, and medical risk factors; perceived cognitive functioning; and emotional symptoms. @entity0 answered questions pertaining to themselves (" @entity0 page") or to a relative or friend ("proxy page"). @entity0 also completed a novel short-delayed recognition memory test. Subjects received personalized feedback about their risk factors and were advised to seek clinical evaluation for concerning symptoms. By November 2009, 500 respondents completed the @entity0 page. RESULTS: The 352 respondents aged 50 years or older (M = 62 years) included a high percentage of @entity0 (72%) and college graduates (67%). Among the respondents, only 10% complained of having severe @entity4 , whereas 38% reported having a first-degree relative who experienced severe @entity4 . The prevalence of major neurologic risk factors was low. Although the delay interval for the recognition memory test averaged around 2 minutes, there was sufficient variability in performance. Individuals with scores  <=10th percentile were significantly older and more likely to be @entity0 , have @entity2 , and report having severe @entity4 . CONCLUSIONS: History of major @entity3 risk factors can be ascertained through the Internet, and several of these factors are shown to be moderately predictive of performance on a brief test of episodic memory. These data provide preliminary validation of the @entity3 Risk Assessment for identifying current @entity1 , and suggest its potential for assessing future @entity3 risk. Ongoing studies will further establish the validity of these findings against proxy reports of cognitive and functional decline, the results of more detailed cognitive assessments, and formal clinical diagnoses.

title: Preliminary findings from an internet-based XXXX risk assessment.

answer: @entity3


abstract: Enormous progress in the treatment of @entity4 over the last five decades has emerged as a result of organized clinical investigations. Although interferon represented one of the initial major therapeutic advances in the management of this disease in 1984, the subsequent introduction of purine @entity3 analogs ( @entity6 and @entity5 ) changed the natural history of this @entity2 by achieving a high rate of complete and durable remissions. The disease-free survival after effective therapy has not reached a plateau, suggesting control but not cure of the disease. Identification of minimal @entity1 in @entity0 achieving a complete hematologic remission provides insight into the potential source for predicting eventual relapse. Modern strategies of targeted therapies directed against immunophenotypic markers on the leukemic cells provide hope that improved long-term control of the disease is possible. Combined chemoimmunotherapy may hold the highest promise for disease eradication, but the optimal strategy for using this approach is under active investigation. Despite the perception by hematologists that this disease has already been conquered, there are critically important unanswered questions that remain. Investigation of the bone marrow microenvironment and its impact on minimal @entity1 may ultimately prevent relapse. Consideration of the median age of @entity0 at diagnosis combined with a substantial relapse rate mandates continued pursuit of improved therapy. The ultimate goal will be to achieve cure rather than simple control of the disease.

title: Modern strategies for XXXX .

answer: @entity4


abstract: OBJECTIVE: To demonstrate differences in foveal contrast sensitivity (CS) between @entity5 using a simple, rapid computerized test. METHODS: This study included consecutive @entity0 with @entity4 (35 eyes) and age-matched control @entity0 (23 eyes) with visual acuity of 20/30 or better. @entity0 with any other @entity6 , including @entity3 , were excluded. All @entity0 underwent a comprehensive ocular examination, perimetry, and CS. Contrast sensitivity was examined by means of 2 computerized psychophysical tests. The transient method included the presentation of a target in a temporal, 2-alternative, forced-choice procedure, and the static method involved 4 forced-choice procedures. The targets were Gabor patches with spatial frequencies of 1.5 to 9.0 cycles per degree. The tests were conducted under photopic and mesopic conditions. RESULTS: Significantly lower foveal CS was found in @entity5 under photopic and mesopic conditions for all spatial frequencies (P < .01). The transient and static methods yielded similar results and were significantly correlated (P < .001). All transient photopic and mesopic CSs were significantly correlated with cup to disc ratio (P < .05). The static photopic spatial frequency of 6 cycles per degree was significantly correlated with the severity of the @entity1 . CONCLUSIONS: The results indicate that foveal CS is impaired in @entity4 despite good visual acuity, suggesting that central @entity2 occurs in @entity4 . The similarity between the 2 methods of testing implies that the static method, being the shorter and easier one, may be used in future research. Further research is necessary to establish a CS testing role in the screening and monitoring of @entity4 .

title: Reduced mesopic and photopic foveal contrast sensitivity in XXXX .

answer: @entity4


abstract: @entity3 ss. jejuni has recently been recognized as a frequent enteric pathogen of @entity0 . Although long known as a significant pathogen of domestic animals, little is known regarding mechanisms of colonization and pathogenesis. In an effort to study the colonization and morphology of this organism, we used scanning electron microscopy to examine ilea and colons from @entity1 in which a @entity0 isolate of @entity3 ss. jejuni had been inoculated. When inoculated into the ileum of the @entity1 , a transient colonization was observed by 24 hours and had disappeared by 48 hours. Colonization of the colon first appeared at 48 hours and persisted at least three weeks. When inoculated directly into the colon, colonization appeared within 24 hours in the colon and persisted at least 16 days. Severe @entity2 were observed in colons only in those @entity1 which were inoculated via the colon. In the infected colons, the @entity3 ss. jejuni organisms were enmeshed in a fibrous network which may play a role in the attachment of bacteria to the mucosal surface. Differences between the morphology of @entity3 ss. jejuni in the @entity1 model and that found in pure culture were observed and may represent distinct tissue and culture phases of growth.

title: XXXX ss. Jejuni, a newly recognized enteric pathogen: morphology and intestinal colonization.

answer: @entity3


abstract: The transplacental effects of @entity4 on the skeleton of neonatal @entity0 has been investigated. Pregnant @entity0 were injected intramuscularly with 0.75 mg @entity4 daily on days 11-19 of gestation. The @entity0 were allowed to deliver and pups were weighed on days 1, 3, 5, 10, 15, 20 and 30 and compared to controls. Light microscopy of non-decalcified longitudinal sections of bones revealed mineral precipitates throughout the zone of @entity3 cartilage most prominent on days 1, 3 and 5 and gradually disappearing on days 10-20. Transmission electron microscopy revealed intracellular @entity2 of maturing and @entity3 chondrocytes in addition to abnormal @entity2 of the interstitial substance. @entity1 crystals were not necessarily associated with matrix vesicles. Scanning electron microscopy of long bones revealed a wide zone of calcified intercartilagenous matrix representing the calcified proliferating and @entity3 zones. In this area, the calcospherites varied in size (0.5-1.4 mu in diameter) and were found in both longitudinal and transverse septa. No significant differences in the distribution and shape of cartilage matrix vesicles between experimental and control animals was observed. However, the fact that mineral crystals in experimental animals was not necessarily associated with matrix vesicles points to the possibility that this "pathological @entity2 " may utilize a different mechanism than the normal process through matrix vesicles.

title: Transplacental effects of XXXX on @entity2 and ossification of long bones in @entity0 .

answer: @entity4


abstract: The transplacental effects of @entity4 on the skeleton of neonatal @entity0 has been investigated. Pregnant @entity0 were injected intramuscularly with 0.75 mg @entity4 daily on days 11-19 of gestation. The @entity0 were allowed to deliver and pups were weighed on days 1, 3, 5, 10, 15, 20 and 30 and compared to controls. Light microscopy of non-decalcified longitudinal sections of bones revealed mineral precipitates throughout the zone of @entity3 cartilage most prominent on days 1, 3 and 5 and gradually disappearing on days 10-20. Transmission electron microscopy revealed intracellular @entity2 of maturing and @entity3 chondrocytes in addition to abnormal @entity2 of the interstitial substance. @entity1 crystals were not necessarily associated with matrix vesicles. Scanning electron microscopy of long bones revealed a wide zone of calcified intercartilagenous matrix representing the calcified proliferating and @entity3 zones. In this area, the calcospherites varied in size (0.5-1.4 mu in diameter) and were found in both longitudinal and transverse septa. No significant differences in the distribution and shape of cartilage matrix vesicles between experimental and control animals was observed. However, the fact that mineral crystals in experimental animals was not necessarily associated with matrix vesicles points to the possibility that this "pathological @entity2 " may utilize a different mechanism than the normal process through matrix vesicles.

title: Transplacental effects of @entity4 on XXXX and ossification of long bones in @entity0 .

answer: @entity2


abstract: The transplacental effects of @entity4 on the skeleton of neonatal @entity0 has been investigated. Pregnant @entity0 were injected intramuscularly with 0.75 mg @entity4 daily on days 11-19 of gestation. The @entity0 were allowed to deliver and pups were weighed on days 1, 3, 5, 10, 15, 20 and 30 and compared to controls. Light microscopy of non-decalcified longitudinal sections of bones revealed mineral precipitates throughout the zone of @entity3 cartilage most prominent on days 1, 3 and 5 and gradually disappearing on days 10-20. Transmission electron microscopy revealed intracellular @entity2 of maturing and @entity3 chondrocytes in addition to abnormal @entity2 of the interstitial substance. @entity1 crystals were not necessarily associated with matrix vesicles. Scanning electron microscopy of long bones revealed a wide zone of calcified intercartilagenous matrix representing the calcified proliferating and @entity3 zones. In this area, the calcospherites varied in size (0.5-1.4 mu in diameter) and were found in both longitudinal and transverse septa. No significant differences in the distribution and shape of cartilage matrix vesicles between experimental and control animals was observed. However, the fact that mineral crystals in experimental animals was not necessarily associated with matrix vesicles points to the possibility that this "pathological @entity2 " may utilize a different mechanism than the normal process through matrix vesicles.

title: Transplacental effects of @entity4 on @entity2 and ossification of long bones in XXXX .

answer: @entity0


abstract: Lymphocyte subset phenotypes in peripheral blood and axillary lymph node cell isolated from 28 @entity1 undergoing surgery for @entity0 were determined by two-color immunofluorescence with monoclonal antibodies and flow cytometric analysis. Lymphocyte subpopulation proportions were determined with combinations of monoclonal antibodies directed against the @entity4 , Leu 3, @entity6 , @entity5 , Leu 11, Leu 12, Leu 15, Leu M3, and HLA-DR surface markers. @entity1 were staged according to the postsurgical-pathological modification of the Tumor-Node-Metastases staging system, for analysis of tissue source (lymph node versus peripheral blood) and stage of disease as factors influencing lymphocyte subset size. Activated @entity4 +DR+ and Leu 3+DR+T-cells were elevated in stage 2 @entity3 compared to Stage 1. Elevation of @entity4 +8+ circulating T-cells and a reciprocal depression of @entity4 +8- T-cells were also seen in Stage 2 @entity1 when compared to Stage 1. Total T-cells, B-cells, @entity4 +, and Leu 3+ T-cell subsets and natural killer phenotypes defined by @entity6 and Leu 11 were unchanged in the peripheral blood of Stages 1 and 2 @entity0 . Regional lymph nodes from Stage 1 were found to contain a high frequency of Leu 3+ cells which dropped significantly in Stage 2 @entity1 ; this was found to be numerically due to a sharp decrease in the Leu 3+8- subpopulation in Stage 2 @entity1 . Elevated B-cells (Leu 12+), activated T-cells ( @entity4 +DR+ and Leu 3+DR+), total @entity4 + cells, and @entity6 -11+ natural killer cells were demonstrated in Stage 2 lymph nodes when compared to Stage 1. Generally, no differences in subpopulations were seen when level 1 (low axillary) lymph node cells were compared to level 3 (high axillary) lymph node cells at each stage of the disease. These findings demonstrate substantial differences in the profile of lymphocyte phenotypes between Stage 1 and Stage 2 @entity0 , especially in the ipsilateral regional nodes. The findings presented in this study suggest that changes in local-regional immunocompetent cell subsets may be related to metastasis of @entity2 to the regional nodes and progression of disease without being fully reflected in the systemic circulation.

title: Monoclonal antibody-defined phenotypes of regional lymph node and peripheral blood lymphocyte subpopulations in early XXXX .

answer: @entity0


abstract: This premature female @entity0 died soon after birth. She had numerous gross anomalies and was found on cytogenic studies to have @entity6 . Polytomographic and histologic studies of the left ear revealed @entity1 including complete aural @entity3 , non-pneumatization of the middle ear with a vertical shelf of bone in the mid portion of the middle ear, absence of the stapes and oval window and bony closure of the round window niche. The cochlea is flat in shape and shows one and a half turns with incomplete formation of the modiolus. The intersaccular septum is rudimentary but the @entity5 is clearly seen in Rosenthal's canal through the one and a half turns. The organ of Corti is well developed and contains hair cells. The stria vascularis is present. The utricular and saccular maculae as well as all cristae are well developed and contain hair cells. The saccular wall is collapsed onto an @entity4 appearing otolithic membrane. The utricle is dilated, the lateral semicircular canal appears short and the bony canal is wide. The flattened and shortened cochlea with deformities of the cochlear duct, and the large vestibule resembles Mondinis @entity2 .

title: [Temporal bone histopathology in a case of XXXX (author's transl)].

answer: @entity6


abstract: One of the approaches for the treatment of @entity1 involves the coadministration of @entity2 , a mood stabilizer, with a   -adrenoceptor antagonists possessing an antidepressant effect. Since @entity2 accelerates the recovery of a   (D)-adrenoceptors following their irreversible inactivation with @entity5 ( @entity5 ), our aim was to examine if it could be to some changes in @entity3 gene expression which codifies these adrenoceptors. Animals were treated with @entity4 (120 mg/kg i.p.) or saline once a day for 10 days. A group of @entity2 - or saline-treated @entity0 was killed 48 h after the last injection. The remaining animals were treated with EEDQ and were killed at 0.25, 4 and 14 days following this administration. Total RNA was extracted from cerebral cortex and @entity3 gene expression was measured by RT-QPCR. The results show that chronic @entity2 raised the @entity3 gene expression (P < 0.05), and after EEDQ administration this expression decreased to the basal level. No change in @entity3 gene expression was detected in the saline-treated group. However, EEDQ administration produced an insignificant increase in a   -adrenoceptors mRNA levels followed by a progressive decrease until basal levels. @entity2 produced an overexpression of the @entity3 gene after chronic treatment that made the neuron ready to produce a   -adrenoceptors to deal with their inactivation.

title: Regulation of a   -adrenoceptor gene expression by chronic XXXX treatment in @entity0 brain.

answer: @entity2


abstract: One of the approaches for the treatment of @entity1 involves the coadministration of @entity2 , a mood stabilizer, with a   -adrenoceptor antagonists possessing an antidepressant effect. Since @entity2 accelerates the recovery of a   (D)-adrenoceptors following their irreversible inactivation with @entity5 ( @entity5 ), our aim was to examine if it could be to some changes in @entity3 gene expression which codifies these adrenoceptors. Animals were treated with @entity4 (120 mg/kg i.p.) or saline once a day for 10 days. A group of @entity2 - or saline-treated @entity0 was killed 48 h after the last injection. The remaining animals were treated with EEDQ and were killed at 0.25, 4 and 14 days following this administration. Total RNA was extracted from cerebral cortex and @entity3 gene expression was measured by RT-QPCR. The results show that chronic @entity2 raised the @entity3 gene expression (P < 0.05), and after EEDQ administration this expression decreased to the basal level. No change in @entity3 gene expression was detected in the saline-treated group. However, EEDQ administration produced an insignificant increase in a   -adrenoceptors mRNA levels followed by a progressive decrease until basal levels. @entity2 produced an overexpression of the @entity3 gene after chronic treatment that made the neuron ready to produce a   -adrenoceptors to deal with their inactivation.

title: Regulation of a   -adrenoceptor gene expression by chronic @entity2 treatment in XXXX brain.

answer: @entity0


abstract: PURPOSE: The purpose of our study was to compare the equipotent doses of @entity2 and @entity3 for walk-out criteria and the characteristics of spinal anesthesia in inguinal herniorrhaphy surgery. METHODS: Combined spinal-epidural anesthesia was performed. Adult @entity0 were randomly allocated to receive 5  mg 0.5% @entity2 plus 25   g @entity4 (group RF, n  =  25) or 3.75  mg 0.75% @entity3 plus 25   g @entity4 (group LF, n  =  25). Each solution was hypobaric, and the same volume, 3  ml, was administered. Sensory and motor block characteristics, hemodynamic changes, side effects, number of @entity0 having ability to stand and walk at the end of the operation, time to first analgesic requirement, time to urination, time to getting out of bed (ambulation), and time to home discharge were determined. RESULTS: Sensory block onset time and time to reach the T6 dermatome were significantly shorter in group LF, whereas time to the two-segment regression and time to first analgesic requirement were significantly shorter in group RF. All @entity0 in group LF were Bromage 0. Time to home discharge was shorter in group LF, but this difference was not statistically significant. CONCLUSION: We suggest that both local anesthetics can be used in walking spinal technique. @entity3 may be an alternative local anesthetic for walking spinal anesthesia as it provides minimum motor block and a long duration of @entity1 , even if its use is not associated with a shorter home discharge time.

title: Low-dose XXXX or @entity3 walking spinal anesthesia in ambulatory inguinal herniorrhaphy.

answer: @entity2


abstract: PURPOSE: The purpose of our study was to compare the equipotent doses of @entity2 and @entity3 for walk-out criteria and the characteristics of spinal anesthesia in inguinal herniorrhaphy surgery. METHODS: Combined spinal-epidural anesthesia was performed. Adult @entity0 were randomly allocated to receive 5  mg 0.5% @entity2 plus 25   g @entity4 (group RF, n  =  25) or 3.75  mg 0.75% @entity3 plus 25   g @entity4 (group LF, n  =  25). Each solution was hypobaric, and the same volume, 3  ml, was administered. Sensory and motor block characteristics, hemodynamic changes, side effects, number of @entity0 having ability to stand and walk at the end of the operation, time to first analgesic requirement, time to urination, time to getting out of bed (ambulation), and time to home discharge were determined. RESULTS: Sensory block onset time and time to reach the T6 dermatome were significantly shorter in group LF, whereas time to the two-segment regression and time to first analgesic requirement were significantly shorter in group RF. All @entity0 in group LF were Bromage 0. Time to home discharge was shorter in group LF, but this difference was not statistically significant. CONCLUSION: We suggest that both local anesthetics can be used in walking spinal technique. @entity3 may be an alternative local anesthetic for walking spinal anesthesia as it provides minimum motor block and a long duration of @entity1 , even if its use is not associated with a shorter home discharge time.

title: Low-dose @entity2 or XXXX walking spinal anesthesia in ambulatory inguinal herniorrhaphy.

answer: @entity3


abstract: 112 @entity0 with @entity2 have been studied at diagnosis for the presence of blood clonal B-cell excess (CBE), defined as a ratio between kappa+ and lambda+ lymphocytes outside the normal range (0.9-3.5). 48 @entity0 (43%) had CBE. The increase in light chain-bearing lymphocytes was always that of the M component light chain isotype. The proportions of @entity0 exhibiting CBE were the same in different stages. The response frequency was not influenced by the presence of CBE. However, @entity0 with CBE had a shorter remission duration time (p less than 0.001) and total survival (p less than 0.05) than those without CBE. This was also noticed when each clinical stage was analyzed separately. Moreover, survival was shorter in @entity0 with a large fraction of CBE than in those with a small one. Cox regression analysis revealed that CBE was a much stronger predictor of remission duration than age, clinical stage and @entity1 . CBE and response to initial treatment independently were the best factors to indicate survival. It is suggested that analysis of CBE should be included in the clinical characterization of untreated @entity0 with @entity2 .

title: Blood clonal B cell excess at diagnosis in XXXX : relation to prognosis.

answer: @entity2


abstract: OBJECTIVE: @entity7 rarely occur in the retropharynx with only three cases reported in the current literature. The most common symptom associated with @entity7 is @entity3 . We report a @entity7 with an unusual clinical presentation of neck stiffness and @entity1 . STUDY DESIGN: Case report and review of literature. METHODS: A 42 year old @entity0 presented with incapacitating @entity4 and neck stiffness as well as @entity3 . Neurological work up was normal. Imaging revealed a hyper-dense, ill-defined, diffuse right retropharyngeal mass suggestive of a possible @entity6 with no communication with the cervical spine. Surgical removal was uneventful and associated with a post-operative @entity5 . In follow-up, @entity3 and neck symptoms improved. CONCLUSION: @entity7 can occur in a wide age range of @entity0 . @entity2 via a cervical approach offers definitive therapy but maybe associated with an iatrogenic @entity5 for which the @entity0 should be counseled prior to operative intervention. @entity4 is an atypical symptom that needs to be worked up to rule out a communication with the spinal column prior to surgical removal. @entity0 must be counseled that atypical symptoms may not completely resolve with surgical treatment.

title: XXXX presenting with neck stiffness: report of a case and review of the literature.

answer: @entity7


abstract: A 29-year-old @entity0 , who had been treated with @entity4 for 3 years because of generalized @entity1 , ingested a large amount of this drug in an attempt to suicide. The exact amount he had swallowed could not be determined. The @entity0 arrived in the intensive care unit in a deep @entity3 , was intubated, and artificially ventilated. He developed a massive @entity6 , as proved by computerized tomography (CT). This was supported by electroencephalography (EEG). The measured value for the concentration of @entity4 in serum was markedly elevated on the day of admission (2300 mumol/l; therapeutic range 350-700 mumol/l). Treatment with @entity7 , @entity2 , and glucocorticoids was initiated. A second CT scan performed 9 days after admission showed a complete normalization and the EEG yielded a markedly improved pattern. At this point the @entity0 slowly regained @entity5 . We conclude that in @entity0 with an acute @entity4 intoxication, care should be taken with regard to the development of a severe @entity6 , which in the reported case could be treated successfully.

title: A case of valproate intoxication with excessive XXXX .

answer: @entity6


abstract: Fifteen @entity0 with @entity2 commencing CAPD treatment were studied by a sensitive ferrokinetic technique. All were severely anaemic with a low red cell volume (RCV). Plasma volume (PV) was raised in twelve. Mean red cell lifespan (MRCL) was reduced in eleven subjects, and marrow @entity1 turnover (MIT) was inappropriately low but this was not related to @entity4 levels. Six @entity0 were restudied after several months CAPD. PV fell in four and RCV increased in all six. MRCL rose to normal in three. The other three subjects has an increase in MIT. @entity4 levels did not change significantly. The major cause of @entity3 is a failure of erythropoiesis to match fully the demands of red cell destruction.

title: Erythropoiesis in the XXXX of @entity2 : the response to CAPD.

answer: @entity3


abstract: Fifteen @entity0 with @entity2 commencing CAPD treatment were studied by a sensitive ferrokinetic technique. All were severely anaemic with a low red cell volume (RCV). Plasma volume (PV) was raised in twelve. Mean red cell lifespan (MRCL) was reduced in eleven subjects, and marrow @entity1 turnover (MIT) was inappropriately low but this was not related to @entity4 levels. Six @entity0 were restudied after several months CAPD. PV fell in four and RCV increased in all six. MRCL rose to normal in three. The other three subjects has an increase in MIT. @entity4 levels did not change significantly. The major cause of @entity3 is a failure of erythropoiesis to match fully the demands of red cell destruction.

title: Erythropoiesis in the @entity3 of XXXX : the response to CAPD.

answer: @entity2


abstract: During the 1960s, it was suggested that, at least in clinical stage I disease, simple mastectomy or even wide excision, plus radiotherapy to the breast and gland fields resulted in the same distant recurrence rate and survival as the orthodox radical operation. It was thought that local control of the disease was not important in terms of ultimate prognosis and it was felt that minimal surgery incurred no penalty. It was forecast that @entity0 would soon be treated by radiotherapy alone, possibly even without @entity2 . Four developments have materially affected the situation. 1. It has been shown that assays of hormone receptors should be carried out on all primary @entity2 . 2. In clinical stage II disease, it has been demonstrated that restricted surgery results in a penalty in terms of distant recurrence and survival. 3. It is now realised that the number of involved axillary lymph nodes must be known to evaluate future prognosis. 4. Adjuvant chemo or endocrine therapy have proved to be effective in treating @entity1 with heavy axillary node involvement. These developments mean that the effective treatment of early @entity0 must entail @entity2 , achieve local control of disease and include axillary node dissection. Currently, only the modified radical mastectomy effectively equates with these three aims. Nevertheless, it is possible that @entity2 excision, irradiation to the @entity2 bed and breast, and axillary node dissection would achieve the same object whilst conserving the breast.

title: The surgeon's role in primary XXXX .

answer: @entity0


abstract: During development of vertebrate cerebellum, a multiple innervation of each Purkinje cell (PC) by several climbing fibers (CFs) (Cr  pel, F., J. Mariani, and N. Delhaye-Bouchaud (1976) J. Neurobiol. 7: 567-578; Mariani, J., and J. -P. Changeux (1981) J. Neurosci. 1: 696-702) precedes the one-to-one relationship characteristic of the adult stage. In the present study, the spontaneous activity of inferior olivary neurons (whose axons constitute the CFs) and the spontaneous activity elicited in PCs by the @entity1 system were investigated in developing @entity0 . Extracellular unitary recordings were obtained in medial and dorsal accessory olives from 249 neurons from 1-day-old to adult animals. The mean discharge rate varied from 0.19 spike . @entity2 on day 1 to 1.69 spikes . @entity2 on postnatal day 21 and 1.78 spikes . @entity2 in adult animals. Although the spontaneous discharge was low, interspike interval histograms were constructed for a sample of cells. Their modal value varied from a mean value of 660 msec on day 1 to 250 msec in the adult with, however, marked variations at each age in the young animals. Intracellular recordings from PCs were performed in @entity0 ranging in age from 5 to 15 postnatal days. The spontaneous (i.e., asynchronous) discharge of excitatory postsynaptic potentials mediated neurons at the same age. The main results are the following: (1) In PCs innervated by one @entity1 , the mean frequency of @entity1 -EPSPs was similar to the discharge of inferior olivary neurons; (2) in PCs innervated by several CFs, the mean discharge of @entity1 -EPSPs was much higher than the discharge of inferior olivary neurons; (3) as a whole, the @entity1 -mediated activity of PCs decreased from day 5 to day 11, while the multiple innervation disappeared; from then on, the activity increased with the maturation of inferior olivary neurons until adult values. The ratio of the frequencies of @entity1 -EPSPs and olivary neurons discharges gives an approximate mean number of @entity1 collaterals per PC at each age; it varied from 3.6 on day 5 to values close to 1 on day 11 and the following days.

title: Ontogenesis of olivocerebellar relationships. II. Spontaneous activity of inferior olivary neurons and climbing fibermediated activity of cerebellar Purkinje cells in developing XXXX .

answer: @entity0


abstract: The hormonal status of @entity0 with @entity5 has been investigated in numerous studies. Little, however, is known about changes of sexual hormones in @entity0 afflicted by this disorder. In a study of 31 postmenopausal @entity0 (mean age 63 +/- 8 years) suffering from @entity2 of various etiology (alcoholic, n = 8; posthepatitic B, n = 1; PBC, n = 5; cryptogenetic, n = 17) the blood levels of @entity1 (E2), @entity6 (E1), @entity7 (A), @entity4 (T) and basal and stimulated values of gonadotropins are reported and compared with the data obtained in an age-matched control group (n = 9). In @entity2 a significant increase of the median E2 (28 vs 12 pg/ml, P less than 0.01) was found, whereas the changes of the blood levels of E1 (88 vs 76 pg/ml), A (63 vs 111 ng/dl), and T (0.30 vs 0.15 ng/ml) did not attain statistical significance in comparison to controls. Within the study group, however, a significant positive correlation with the degree of decompensation of @entity2 (Childscore A-C) was observed for the @entity3 hormones measured. Thus, in subgroup C the hormone levels are higher than physiologically expected for postmenopausal @entity0 . On the other hand the median FSH (32 vs 48 mU/ml, P less than 0.05) is significantly lower in @entity2 compared to controls with a trend to decreased values of LH. Very low levels of LH and FSH are found in decompensated @entity2 . The decrease of LH and FSH can partly be explained by the rise of peripheral hormones (i.e. E2, E1, and in some cases T and A).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Sex hormones and the hypophyseo-gonadal axis in females with XXXX in postmenopause].

answer: @entity5


abstract: @entity3 ( @entity4 ) is a clinically used drug with mutagenic and antitumor activities, presumably elicited through its covalent binding to DNA, however, little is known about @entity4 binding to DNA in vivo. @entity10 -postlabeling method that does not require radiolabeled test compounds was employed here to study the formation of DNA adducts in somatic and reproductive tissues of @entity2 24 h after an i.p. dose of 9 mg/kg @entity4 . Among 14 tissues studied in female @entity2 , @entity4 -DNA adduct levels were within a 2-fold range in 11 tissues, i.e. bladder, colon, esophagus, heart, kidney, liver, lung, ovary, pancreas, small intestine and stomach (minimum levels of 9.6-21.9 adducts per 10(7) N). Three other tissues, i.e. brain, spleen and thymus, exhibited lower adduct levels (0.2 5.4 and 1.4 adducts, respectively, per 10(7) N). Liver DNA adduct levels were 32% lower in male than in female @entity2 . Testicular DNA contained 2.5 adducts per 10(7) N, i.e. 5.3 times less than ovarian DNA. 32P-labeled adduct patterns were qualitatively similar among the different tissues and consisted of 10 adducts, one of which comprised 71 (+/- 5)% of the total. All these adducts were chromatographically identical to adducts formed by the reaction of chemically reduced @entity4 with DNA in vitro, demonstrating that metabolic activation of @entity4 occurred via reduction. Using homopolydeoxyribonucleotides modified with @entity4 , in vivo adducts were shown to be mostly (greater than 90%) @entity6 derivatives and small amounts of @entity7 , @entity8 and @entity9 products. Most of the adducts appeared to be monofunctional derivatives of DNA @entity5 . Dose-dependent @entity4 -DNA adduct formation was determined in @entity2 liver over an 82-fold range of @entity4 administered (0.11-9.0 mg/kg). The lowest dose level studied was 4.5 times lower than the recommended single dose for @entity0 @entity1 chemotherapy (20 mg/m2). Thus, these results predict that 32P-postlabeling methodology is suitable to monitor and quantify DNA adducts in tissue biopsies of @entity0 receiving @entity4 chemotherapy.

title: 32P-analysis of DNA adducts in somatic and reproductive tissues of @entity2 treated with the anticancer antibiotic, XXXX .

answer: @entity3


abstract: @entity3 ( @entity4 ) is a clinically used drug with mutagenic and antitumor activities, presumably elicited through its covalent binding to DNA, however, little is known about @entity4 binding to DNA in vivo. @entity10 -postlabeling method that does not require radiolabeled test compounds was employed here to study the formation of DNA adducts in somatic and reproductive tissues of @entity2 24 h after an i.p. dose of 9 mg/kg @entity4 . Among 14 tissues studied in female @entity2 , @entity4 -DNA adduct levels were within a 2-fold range in 11 tissues, i.e. bladder, colon, esophagus, heart, kidney, liver, lung, ovary, pancreas, small intestine and stomach (minimum levels of 9.6-21.9 adducts per 10(7) N). Three other tissues, i.e. brain, spleen and thymus, exhibited lower adduct levels (0.2 5.4 and 1.4 adducts, respectively, per 10(7) N). Liver DNA adduct levels were 32% lower in male than in female @entity2 . Testicular DNA contained 2.5 adducts per 10(7) N, i.e. 5.3 times less than ovarian DNA. 32P-labeled adduct patterns were qualitatively similar among the different tissues and consisted of 10 adducts, one of which comprised 71 (+/- 5)% of the total. All these adducts were chromatographically identical to adducts formed by the reaction of chemically reduced @entity4 with DNA in vitro, demonstrating that metabolic activation of @entity4 occurred via reduction. Using homopolydeoxyribonucleotides modified with @entity4 , in vivo adducts were shown to be mostly (greater than 90%) @entity6 derivatives and small amounts of @entity7 , @entity8 and @entity9 products. Most of the adducts appeared to be monofunctional derivatives of DNA @entity5 . Dose-dependent @entity4 -DNA adduct formation was determined in @entity2 liver over an 82-fold range of @entity4 administered (0.11-9.0 mg/kg). The lowest dose level studied was 4.5 times lower than the recommended single dose for @entity0 @entity1 chemotherapy (20 mg/m2). Thus, these results predict that 32P-postlabeling methodology is suitable to monitor and quantify DNA adducts in tissue biopsies of @entity0 receiving @entity4 chemotherapy.

title: 32P-analysis of DNA adducts in somatic and reproductive tissues of XXXX treated with the anticancer antibiotic, @entity3 .

answer: @entity2


abstract: A vast array of new antiarrhythmic agents have joined the old agents among the clinician's available resources. While treatment of @entity3 is completely justifiable for @entity0 with symptoms, their use to prevent @entity4 has not yet been established. Because of their potential risks, the benefit/risk ratio must always be kept in mind. If we elect to treat @entity0 who have benign or potentially lethal @entity3 (usually to eliminate refractory symptoms) we typically begin with either a beta blocker or one of the new potent class IC antiarrhythmic agents such as @entity7 or @entity9 . These drugs cause few side effects, no organ @entity1 , and in the case of @entity9 or @entity7 , have marked potency. Few important proarrhythmic effects are seen with these potent drugs in this group of @entity0 . If these fail, one can try either a class IA or IB agent or a combination of a IA and IB agent. We always avoid @entity5 . In @entity0 with lethal @entity3 , one should choose a drug without negative inotropic potential such as @entity6 or @entity9 as initial therapy. The combination of IA and IB agents should also be considered early in therapy. In @entity0 with overt @entity2 with markedly depressed left ventricular function in the setting of lethal @entity3 , @entity8 , beta blockers, and @entity7 should be avoided. @entity5 is used in this population only when the other available agents have proven to be ineffective or badly tolerated.

title: Antiarrhythmic agents for chronic XXXX .

answer: @entity3


abstract: BACKGROUND: Post-operative @entity1 (POCD) can affect 30% of orthopedic surgery @entity0 . We hypothesized that perioperative temperature has an impact on POCD. METHODS: We included 150 @entity0 over 65 years of age scheduled for total knee replacement under spinal anesthesia. They were randomized to receive standard care (sheet cover) or active warming. Neurocognitive assessment (11 subtests) was performed pre-operatively and at day 4 (three subtests) and 3 months (10 subtests). A control group of 55 nonsurgical @entity0 took the same tests at equivalent times. POCD was defined as an individual score decrease of more than 2 standard deviations (SDs) below the baseline on at least two subtests or 2 SDs in the combined z-score, in both cases using control-adjusted changes. RESULTS: Tympanic temperature declined below 35   C in 88% of standard-care @entity0 ; 25.3% of warmed @entity0 had a temperature >= 36   C. On day 4, 3.2% of standard-care @entity0 and 19.4% of warmed @entity0 had POCD (P=0.0058). At 3 months, there were no between-group differences (standard care, 14.3%; warmed, 6.5%) (P=0.2440). CONCLUSIONS: Perioperative warming was associated with a higher incidence of @entity1 at 4 days after total knee replacement in @entity0 >65 years of age.

title: Intraoperative warming and post-operative XXXX after total knee replacement.

answer: @entity1


abstract: BACKGROUND: Long-term success reports by Dr. Ponseti with the Ponseti method in the treatment of @entity2 have led to a renewed interest in this method among pediatric orthopedists. The purpose of this study is to evaluate mid-term effectiveness of Ponseti method for the treatment of @entity2 . MATERIAL AND METHODS: A total of 49 @entity0 (67 clubfeet) were treated by Ponseti method by single orthopedic surgeon during the period of October 03 to July 07 and were studied prospectively up to July 10 (mean follow up period 5 years, minimum follow-up period of 3 years). Age at the initiation of the treatment, gender, bilaterality, severity of the initial @entity1 measured by Pirani Severity Score System, total numbers of Ponseti casts before the tenotomy, details of tenotomy, compliance with brace and CTEV shoes were examined. Passive range of movements and look of @entity2 are evaluated with mean 5 years follow-up. RESULTS: We followed the functional Ponseti Scoring System and got good to excellent results in 44 @entity0 --89.79% (58 clubfeet--86.56%) at mean five year of follow up. Parents of 32 @entity0 (65.30%) accept the look of the clubfoot nearly normal and parents of 12 @entity0 (24.49%) accept the look of clubfoot as normal. Of the 49 @entity0 who responded to initial Ponseti casting, 14 @entity0 --28.57% (19 clubfeet--28.35%) had relapse at varying age; out of which 9 @entity0 --64.29% (10 clubfeet--52.63%) were corrected by Ponseti casting method, while 5 @entity0 --35.71% (9 clubfeet--47.37%) were resistant to Ponseti method. Poor compliance with the Denis Browne splint was thought to be the main cause of failure in these @entity0 . CONCLUSION: Ponseti method is a safe and satisfactory treatment for @entity2 with mid- term effectiveness.

title: Mid-term results of Ponseti method for the treatment of XXXX --(a study of 67 clubfeet with mean five year follow-up).

answer: @entity2


abstract: The size and activity of the shoot apical meristem is regulated by transcription factors and low molecular mass signals, including the plant hormone cytokinin. The cytokinin status of the meristem depends on different factors, including metabolic degradation of the hormone, which is catalyzed by cytokinin oxidase/dehydrogenase (CKX) enzymes. Here, we show that @entity1 and @entity2 regulate the activity of the reproductive meristems of @entity0 . @entity1 is expressed in the central WUSCHEL (WUS) domain, while @entity2 shows a broader meristematic expression. @entity1 @entity2 double mutants form larger inflorescence and floral meristems. An increased size of the WUS domain and enhanced primordia formation indicate a dual function for cytokinin in defining the stem cell niche and delaying cellular differentiation. Consistent with this, mutation of a negative regulator gene of cytokinin signaling, @entity0 HISTIDINE PHOSPHOTRANSFER PROTEIN 6, which is expressed at the meristem flanks, caused a further delay of differentiation. Terminal cellular differentiation was also retarded in @entity1 @entity2 flowers, which formed more cells and became larger, corroborating the role of cytokinin in regulating flower organ size. Furthermore, higher activity of the @entity1 @entity2 placenta tissue established supernumerary ovules leading to an increased seed set per silique. Together, the results underpin the important role of cytokinin in reproductive development. The increased cytokinin content caused an ~55% increase in seed yield, highlighting the relevance of sink strength as a yield factor.

title: Cytokinin regulates the activity of reproductive meristems, flower organ size, ovule formation, and thus seed yield in XXXX .

answer: @entity0


abstract: The case was a 36-year-old male whose chief complaints were @entity4 and @entity3 . Upper gastrointestinal endoscopy revealed circumferential stenosis in the fourth portion of the duodenum, while CT revealed a @entity1 with a diameter of 60 mm continuing as a single mass from the pancreatic body and tail to the fourth portion of the duodenum, and this was accompanied by findings that raised suspicions of circumferential invasion of the @entity8 ( @entity8 ). Based on these results and biopsy, the @entity0 was diagnosed with @entity6 that was considered to be unresectable. After performing gastrojejunostomy, we administered @entity7 (40 mg/m2, day 1), CDDP (60 mg/m2, day 1), and S-1( 80 mg/m2, day 1-14) for 3 courses. The @entity1 response was PR and the images indicated the @entity8 invasion was disappeared. We judged that the @entity1 could be gone by a resection while preserving the @entity8 . In the surgical findings, the @entity1 continued as a single mass from the pancreatic body and tail to the third portion of the duodenum, and the surrounding area exhibited marked @entity2 . We performed a pancreatic tail resection along with combined resection of third and fourth portions of the duodenum, transverse @entity5 , and left adrenal gland. The case was diagnosed to be well-differentiated @entity6 with duodenal invasion. Cancer invasion was not observed in any of the stripped surfaces surrounding the pancreas. The T3, N1, M0, fStage III antitumor effects were mildly effective. In this case, the treatment was initially started by considering the case as one of @entity1 , but the final results of a pathological diagnosis revealed that it was @entity6 . However, either way, even though the case was unresectable before the chemotherapy performed for @entity1 was significantly effective for the @entity6 . Therefore, a resection became possible, and an R0 resection was also effective.

title: [A case report--locally advanced XXXX was resected after chemotherapy].

answer: @entity6


abstract: We herein report an extremely rare operative case of an isolated extraperitoneal @entity1 of @entity3 . A female @entity0 had undergone a sigmoidectomy for ileus due to sigmoid @entity3 when she was 40 years old. Peritoneal @entity1 , 5 mm in diameter, was on the sigmoid colon mesentery and she was histologically diagnosed as Stage IV. She received @entity6 -based adjuvant chemotherapy for 24 months. Serum @entity5 increased gradually from 36 months after the operation, and CT scan demonstrated bilateral @entity2 . Bilateral oophorectomy was performed at 44 months after the operation. Serum @entity5 decreased temporarily, but increased again. Serum @entity5 increased in spite of giving UFT/LV, so we changed to mFOLFOX6 therapy. Serum @entity5 decreased until it reached to a normal range after 9 courses, and stopped mFOLFOX6 therapy. Four months later, serum @entity5 increased again and PET-CT demonstrated a 3 cm mass with @entity4 in pelvic, and accumulation of FDP. Serum @entity5 decreased until it reached to a normal range after a resection of extraperitoneal mass. A histological examination of the @entity2 revealed a moderately differentiated @entity3 . She has been well without recurrence 77 months after the first operation.

title: [Successfully resected an isolated extraperitoneal @entity1 of sigmoid XXXX --a case report].

answer: @entity3


abstract: We herein report an extremely rare operative case of an isolated extraperitoneal @entity1 of @entity3 . A female @entity0 had undergone a sigmoidectomy for ileus due to sigmoid @entity3 when she was 40 years old. Peritoneal @entity1 , 5 mm in diameter, was on the sigmoid colon mesentery and she was histologically diagnosed as Stage IV. She received @entity6 -based adjuvant chemotherapy for 24 months. Serum @entity5 increased gradually from 36 months after the operation, and CT scan demonstrated bilateral @entity2 . Bilateral oophorectomy was performed at 44 months after the operation. Serum @entity5 decreased temporarily, but increased again. Serum @entity5 increased in spite of giving UFT/LV, so we changed to mFOLFOX6 therapy. Serum @entity5 decreased until it reached to a normal range after 9 courses, and stopped mFOLFOX6 therapy. Four months later, serum @entity5 increased again and PET-CT demonstrated a 3 cm mass with @entity4 in pelvic, and accumulation of FDP. Serum @entity5 decreased until it reached to a normal range after a resection of extraperitoneal mass. A histological examination of the @entity2 revealed a moderately differentiated @entity3 . She has been well without recurrence 77 months after the first operation.

title: [Successfully resected an isolated extraperitoneal XXXX of sigmoid @entity3 --a case report].

answer: @entity1


abstract: A 75-year-old female presented with appetite and weight loss and epigastralgia. CT revealed a primary @entity1 Stage IVb with multiple hepatic metastases. Gastrofiberscopy revealed an invasion to duodenal and bleeding from the @entity0 . For her poor performance status, it seems to be too difficult to undergo a general chemotherapy. So after gastrojejunostomy, transarterial embolization (TAE) was performed. She underwent 2 times TAE. There was a notable reduction in @entity0 size. But pulmonary metastases were found in bilateral lung. She died after 8 months. TAE may be useful for advanced @entity1 with @entity0 vascularity.

title: [A case report--transarterial embolization for advanced XXXX with hepatic metastasis].

answer: @entity1