abstract: One hundred sixty-five nonsmoking @entity4 @entity0 were evaluated by pulmonary function testing. @entity2 and an isolated reduction of the diffusing capacity of @entity5 were the most frequent abnormalities. @entity0 with the @entity9 ( @entity3 , @entity7 , @entity10 , @entity13 , and @entity12 ) had a similar frequency and severity of @entity2 compared with the @entity0 who had @entity11 . @entity9 @entity0 with @entity2 rarely had the anticentromere antibody and had more skin and joint involvement of their hands, compared with other @entity9 @entity0 . @entity6 and rales were most commonly found in @entity0 with @entity2 . @entity1 , shown on chest radiograph, and @entity2 correlated poorly with each other. @entity6 was associated with restrictive disease, and rales were more commonly found in @entity0 with @entity1 . @entity0 with a restrictive abnormality had the worst prognosis, with a 5-year survival rate of 58%, although death from pulmonary causes was uncommon. Comparison of these nonsmoking @entity0 with 137 @entity8 @entity0 who smoked, seen during the same time period, revealed more frequent and severe obstructive changes in smokers. Smoking @entity0 with @entity2 had more severe disease than nonsmoking @entity0 . The single breath diffusing capacity for @entity5 was significantly decreased in the @entity0 who smoked compared with the nonsmokers. These data confirm that @entity2 are common in @entity0 with @entity4 including @entity9 . Smoking appears to have an additive deleterious effect on pulmonary function and should be strongly discouraged.

title: @entity2 in XXXX ( @entity8 ).

answer: @entity4


abstract: In a consecutive series of 56 @entity0 with acute @entity2 , ST segment @entity1 and elevation in the electrocardiographic limb leads I, II, and III were summated for each @entity0 before and immediately after intracoronary streptokinase infusion and the results compared with the angiographic findings. Forty three @entity0 had angiographically confirmed reperfusion of an initially occluded vessel and showed a significant decrease in summated ST shift. The ST segment changes in the limb leads virtually returned to normal in all 43 @entity0 , and in most, inverted T waves developed. Thrombolysis was unsuccessful in 10 @entity0 , and the @entity3 related coronary artery was already patent in three. When these two groups are combined, all 13 @entity0 without reperfusion showed no significant change in summated ST segment shift. During percutaneous transluminal angioplasty inflation of the balloon in the vessel that was previously occluded simulated reocclusion and was followed by new ST elevation if the artery supplied viable myocardium. In a further consecutive study of 54 @entity0 with @entity2 , the precordial R waves and Q waves were studied over the four to six months following infarction using a standardised 48 electrode mapping system. All @entity0 underwent a repeat angiogram after four to six months. In 36 @entity0 the @entity3 related vessel was patent. They showed a significant mean increase in summated precordial R wave amplitude and a reduction in the mean number of precordial leads without R waves. In 18 @entity0 with unsuccessful thrombolysis or reocclusion there was a further reduction in mean summated R wave amplitude and an increased number of precordial leads not showing R waves. Precordial R wave mapping seems to be a valuable non-invasive method of assessing the salvage of myocardium after reperfusion and the damage caused by reocclusion. Loss of R waves in the acute phase of @entity2 does not necessarily mean an irreversibly damaged myocardium.

title: XXXX and thrombolysis. Electrocardiographic short term and long term results using precordial mapping.

answer: @entity2


abstract: The susceptibilities of 36 isolates of the @entity2 group to @entity5 , @entity3 , @entity4 , and @entity0 were determined by using the National Committee for Clinical Laboratory Standards agar dilution reference method and a broth microdilution method using anaerobe, brucella, Schaedler, and brain heart infusion broths. MICs that were greater than or equal to fourfold higher or lower than those of the reference method were considered significant. Major and minor discrepancies in susceptibility interpretation (SI) were also noted. @entity5 showed the greatest number of variations and @entity1 . In 72% of the cases, MICs in broth were greater than or equal to fourfold lower than those obtained by the reference method, resulting in 33% of the major and 22% of the minor discrepancies in SI. A total of 53% of the isolates were resistant to @entity5 by the reference method, but only 11 to 17% were resistant in the various broths. Significant variations in MICs of cefoxitin occurred in 19 to 22% of the isolates; 17 to 19% of the isolates showed major discrepancies and 31 to 58% showed minor discrepancies in SI. A total of 58% of the isolates were resistant to cefoxitin by the reference method, but only 19 to 28% were resistant in the various broths. Significant variations with @entity4 in broths ranged from 32 to 53% and resulted in 3 to 8% of the isolates showing major discrepancies and 33 to 44% showing minor discrepancies in SI. Metronidazole yielded significant variations in MICs in 6 to 28% of the isolates, but no major or minor @entity1 were noted. This study indicates that significant differences in susceptibility results, which appear to be method related, can result when isolates of the @entity2 group are tested. Therefore, studies correlating in vitro results, determined by various methods, to clinical outcome are essential.

title: Antibiotic- and method-dependent variation in susceptibility testing results of XXXX group isolates.

answer: @entity2


abstract: BACKGROUND: Immune checkpoint inhibitors represent a paradigm change in the treatment of @entity3 and other advanced @entity1 . These agents manipulate key immune-regulating pathways to restore immune responses against @entity1 . The success of this approach is demonstrated by ipilimumab (Yervoy  ) for the treatment of advanced @entity3 , with improvement in three-year survival rates of about 20%. Newer checkpoint inhibitors targeting the programmed death-1 (PD-1) pathway have been approved and may have higher response rates and improved tolerability. OBJECTIVES: This article aims to educate nurses and increase their comfort level with these new therapies. METHODS: The mechanism of action of immune checkpoint inhibitors is reviewed, and insight is provided on how nurses can use this knowledge to more effectively care for @entity0 receiving these therapies. FINDINGS: The use of immuno-oncology agents is increasing. Oncology nurses must understand the basic immune mechanism of action responsible for the novel @entity2 profile characterized by immune-related adverse events (irAEs) and clinical response patterns. Managing irAEs with immune checkpoint inhibitors is not necessarily more difficult than with conventional agents, but a difference does exist. Nurses and other healthcare providers must consider the underlying cause of @entity2 with immune checkpoint inhibitors when making management decisions.

title: Understanding Immune Checkpoint Inhibitors for Effective XXXX Care.

answer: @entity0


abstract: Diagnosis of @entity1 is not yet possible with neurophysiological methods. Therefore we investigated the median somatosensory and visually evoked potentials (SEP and VEP) to single and double stimulation, VEP using a special stimulation technique and motor evoked potentials (MEP) employing spinal and transcranial stimulation. In @entity1 the absolute and relative refractory periods of cortical N1 peak of SEP did not differ from that of normal subjects. After single stimulation the cortical N20 latencies were only in 2 of 17 cases delayed. In 8 of 10 cases central conduction time was normal. Also the SEP peaks of brain stem were normal and there was no correlation between symptomatology and SEP results. The data of motor evoked potentials (MEP) demonstrated in all @entity0 a normal central motor conduction time of 5.0 msec. In 30% of @entity0 the VEP data showed a significant delay of P2 latency, independently of clinical status or age. But there were no more P2 alterations after special visual stimulation techniques. In contrast to a good clinical effect in 14 of 19 @entity0 with end-off-dose @entity2 , an improvement of P2 delay could not be noticed during a chronic L-dopa and deprenyl therapy.

title: Somatosensory, motor and special visual evoked potentials to single and double stimulation in " XXXX " an early diagnostic test?

answer: @entity1


abstract: BACKGROUND: Data about @entity6 -eluting balloon (PCB) angioplasty to treat drug-eluting stents (DES) in-stent restenosis (ISR) were mainly collected in selected @entity0 populations in the setting of randomized trials. The main goal of this prospective registry was to confirm the positive findings of these studies in an unselected population in clinical practice. METHODS: Consecutive @entity0 with DES-ISR treated by PCB angioplasty were recruited in this prospective real-world registry. The primary endpoint was clinically driven @entity1 revascularization (TLR) at 9months. Secondary endpoints included acute technical success, in-hospital outcomes, 9-month major adverse @entity3 (MACE) a composite of @entity2 , @entity5 ( @entity5 ) and TLR and the occurrence of target vessel revascularization. RESULTS: A total of 206 @entity0 (67.7  10.2years, 80.6% male, 41.3% diabetics) with 210 lesions were recruited. Unstable @entity4 was present in 55.3% of @entity0 . The time from DES implantation to DES-ISR was 3.0  2.4years. Quantitative analyses revealed that patterns of treated DES-ISR were focal in 55.7% and diffuse in 44.3%. The reference diameter was 2.76  0.64mm. The 9-month follow-up rate was 90.8% (187/206). At 9months, the TLR rate was 7.0% (13/187) whereas the rates for MACE, @entity5 and @entity2 were 10.7% (20/187), 4.8% (9/187) and 2.1% (4/187) respectively. Results were consistent in @entity0 with @entity6 and non- @entity6 -eluting stents (PES) ISR. CONCLUSION: This large prospective registry demonstrated acceptable rates of TLR and MACE at 9months after treatment of DES-ISR by PCB angioplasty. PCB angioplasty was equally effective in @entity0 with PES-ISR and non PES-ISR.

title: Treatment of drug-eluting stents in-stent restenosis with XXXX -coated balloon angioplasty: Insights from the French "real-world" prospective GARO Registry.

answer: @entity6


abstract: PURPOSE: To determine whether neglecting the flow unsteadiness in simplified Bernoulli's equation significantly affects the @entity1 drop estimation. MATERIALS AND METHODS: 3.0T magnetic resonance imaging (MRI) 4D velocity mapping was performed on four healthy volunteers, seven @entity0 with repaired tetralogy of Fallot, and thirteen @entity0 with @entity3 repaired by arterial switch. Pulmonary transvalvular pressure drop was estimated based on two methods: General Bernoulli's Equation (GBE), ie, the most complete form; and @entity2 ( @entity2 ), known as 4V(2) . More than 2300 individual pressure drop measurements were used to compare the simplified and the general Bernoulli's methods. A linear mixed-effects model was employed for statistical analyses, fully accounting for clustering of observations among the methods and systolic phases. RESULTS: The simplified Bernoulli's method systematically underestimated the pressure drop compared to general Bernoulli's method during the entire systolic phase (P < 0.05), including the peak systole, where on average   pSBE/  pGBE=78%. CONCLUSION: The simplified Bernoulli method underestimated the pressure drop during all systolic phases in all the studied subjects. Therefore, it is necessary to take into account the flow unsteadiness for more accurate estimation of the pressure drop. J. Magn. Reson. Imaging 2015.

title: Simplified Bernoulli's method significantly underestimates XXXX drop.

answer: @entity1


abstract: BACKGROUND: World Health Organization step III opioids are required to relieve moderate-to-severe @entity1 ; @entity5 is one of the most frequent opioid-induced side effects. A fixed combination, prolonged-release @entity6 / @entity8 (OXN), was developed with the aim of reducing opioid-related gastrointestinal side effects. The objective of this study was to compare the efficacy and safety of prolonged-release @entity6 ( @entity9 ) alone to OXN in opioid-na  ve @entity1 @entity0 with moderate-to-severe @entity2 . METHODS: Propensity analysis was utilized in this observational study, which evaluated the efficacy, safety, and quality of life. RESULTS: Out of the 210 @entity0 recruited, 146 were matched using propensity scores and included in the comparative analysis. In both groups, @entity2 intensity decreased by    3 points after 60 days, indicating comparable analgesic efficacy. Responder rates were similar between groups. @entity7 was achieved and maintained with similarly low and stable dosages over time (12.0-20.4 mg/d for @entity9 and 11.5-22.0 mg/d for OXN). Bowel Function Index (BFI) and laxative use per week improved from baseline at 30 days and 60 days in OXN recipients (-16, P<0.0001 and -3.5, P=0.02, respectively); BFI worsened in the @entity9 group. The overall incidence of drug-related adverse events was 28.9% in the @entity9 group and 8.2% in the OXN group (P<0.01); @entity3 and @entity4 were two to five times less frequent with OXN. Quality of life improved to a significantly greater extent in @entity0 receiving OXN compared to @entity9 (increase in Short Form-36 physical component score of 7.1 points vs 3.2 points, respectively; P<0.001). CONCLUSION: In @entity0 with chronic @entity1 , OXN provided analgesic effectiveness that is similar to @entity9 , with early and sustained benefits in tolerability. The relationship between responsiveness to OXN and clinical characteristics is currently being investigated.

title: Efficacy and tolerability of oral @entity6 and @entity6 / @entity8 combination in opioid-na  ve @entity1 XXXX : a propensity analysis.

answer: @entity0


abstract: BACKGROUND: World Health Organization step III opioids are required to relieve moderate-to-severe @entity1 ; @entity5 is one of the most frequent opioid-induced side effects. A fixed combination, prolonged-release @entity6 / @entity8 (OXN), was developed with the aim of reducing opioid-related gastrointestinal side effects. The objective of this study was to compare the efficacy and safety of prolonged-release @entity6 ( @entity9 ) alone to OXN in opioid-na  ve @entity1 @entity0 with moderate-to-severe @entity2 . METHODS: Propensity analysis was utilized in this observational study, which evaluated the efficacy, safety, and quality of life. RESULTS: Out of the 210 @entity0 recruited, 146 were matched using propensity scores and included in the comparative analysis. In both groups, @entity2 intensity decreased by    3 points after 60 days, indicating comparable analgesic efficacy. Responder rates were similar between groups. @entity7 was achieved and maintained with similarly low and stable dosages over time (12.0-20.4 mg/d for @entity9 and 11.5-22.0 mg/d for OXN). Bowel Function Index (BFI) and laxative use per week improved from baseline at 30 days and 60 days in OXN recipients (-16, P<0.0001 and -3.5, P=0.02, respectively); BFI worsened in the @entity9 group. The overall incidence of drug-related adverse events was 28.9% in the @entity9 group and 8.2% in the OXN group (P<0.01); @entity3 and @entity4 were two to five times less frequent with OXN. Quality of life improved to a significantly greater extent in @entity0 receiving OXN compared to @entity9 (increase in Short Form-36 physical component score of 7.1 points vs 3.2 points, respectively; P<0.001). CONCLUSION: In @entity0 with chronic @entity1 , OXN provided analgesic effectiveness that is similar to @entity9 , with early and sustained benefits in tolerability. The relationship between responsiveness to OXN and clinical characteristics is currently being investigated.

title: Efficacy and tolerability of oral @entity6 and @entity6 / XXXX combination in opioid-na  ve @entity1 @entity0 : a propensity analysis.

answer: @entity8


abstract: BACKGROUND: World Health Organization step III opioids are required to relieve moderate-to-severe @entity1 ; @entity5 is one of the most frequent opioid-induced side effects. A fixed combination, prolonged-release @entity6 / @entity8 (OXN), was developed with the aim of reducing opioid-related gastrointestinal side effects. The objective of this study was to compare the efficacy and safety of prolonged-release @entity6 ( @entity9 ) alone to OXN in opioid-na  ve @entity1 @entity0 with moderate-to-severe @entity2 . METHODS: Propensity analysis was utilized in this observational study, which evaluated the efficacy, safety, and quality of life. RESULTS: Out of the 210 @entity0 recruited, 146 were matched using propensity scores and included in the comparative analysis. In both groups, @entity2 intensity decreased by    3 points after 60 days, indicating comparable analgesic efficacy. Responder rates were similar between groups. @entity7 was achieved and maintained with similarly low and stable dosages over time (12.0-20.4 mg/d for @entity9 and 11.5-22.0 mg/d for OXN). Bowel Function Index (BFI) and laxative use per week improved from baseline at 30 days and 60 days in OXN recipients (-16, P<0.0001 and -3.5, P=0.02, respectively); BFI worsened in the @entity9 group. The overall incidence of drug-related adverse events was 28.9% in the @entity9 group and 8.2% in the OXN group (P<0.01); @entity3 and @entity4 were two to five times less frequent with OXN. Quality of life improved to a significantly greater extent in @entity0 receiving OXN compared to @entity9 (increase in Short Form-36 physical component score of 7.1 points vs 3.2 points, respectively; P<0.001). CONCLUSION: In @entity0 with chronic @entity1 , OXN provided analgesic effectiveness that is similar to @entity9 , with early and sustained benefits in tolerability. The relationship between responsiveness to OXN and clinical characteristics is currently being investigated.

title: Efficacy and tolerability of oral @entity6 and @entity6 / @entity8 combination in opioid-na  ve XXXX @entity0 : a propensity analysis.

answer: @entity1


abstract: BACKGROUND: World Health Organization step III opioids are required to relieve moderate-to-severe @entity1 ; @entity5 is one of the most frequent opioid-induced side effects. A fixed combination, prolonged-release @entity6 / @entity8 (OXN), was developed with the aim of reducing opioid-related gastrointestinal side effects. The objective of this study was to compare the efficacy and safety of prolonged-release @entity6 ( @entity9 ) alone to OXN in opioid-na  ve @entity1 @entity0 with moderate-to-severe @entity2 . METHODS: Propensity analysis was utilized in this observational study, which evaluated the efficacy, safety, and quality of life. RESULTS: Out of the 210 @entity0 recruited, 146 were matched using propensity scores and included in the comparative analysis. In both groups, @entity2 intensity decreased by    3 points after 60 days, indicating comparable analgesic efficacy. Responder rates were similar between groups. @entity7 was achieved and maintained with similarly low and stable dosages over time (12.0-20.4 mg/d for @entity9 and 11.5-22.0 mg/d for OXN). Bowel Function Index (BFI) and laxative use per week improved from baseline at 30 days and 60 days in OXN recipients (-16, P<0.0001 and -3.5, P=0.02, respectively); BFI worsened in the @entity9 group. The overall incidence of drug-related adverse events was 28.9% in the @entity9 group and 8.2% in the OXN group (P<0.01); @entity3 and @entity4 were two to five times less frequent with OXN. Quality of life improved to a significantly greater extent in @entity0 receiving OXN compared to @entity9 (increase in Short Form-36 physical component score of 7.1 points vs 3.2 points, respectively; P<0.001). CONCLUSION: In @entity0 with chronic @entity1 , OXN provided analgesic effectiveness that is similar to @entity9 , with early and sustained benefits in tolerability. The relationship between responsiveness to OXN and clinical characteristics is currently being investigated.

title: Efficacy and tolerability of oral XXXX and @entity6 / @entity8 combination in opioid-na  ve @entity1 @entity0 : a propensity analysis.

answer: @entity6


abstract: BACKGROUND: World Health Organization step III opioids are required to relieve moderate-to-severe @entity1 ; @entity5 is one of the most frequent opioid-induced side effects. A fixed combination, prolonged-release @entity6 / @entity8 (OXN), was developed with the aim of reducing opioid-related gastrointestinal side effects. The objective of this study was to compare the efficacy and safety of prolonged-release @entity6 ( @entity9 ) alone to OXN in opioid-na  ve @entity1 @entity0 with moderate-to-severe @entity2 . METHODS: Propensity analysis was utilized in this observational study, which evaluated the efficacy, safety, and quality of life. RESULTS: Out of the 210 @entity0 recruited, 146 were matched using propensity scores and included in the comparative analysis. In both groups, @entity2 intensity decreased by    3 points after 60 days, indicating comparable analgesic efficacy. Responder rates were similar between groups. @entity7 was achieved and maintained with similarly low and stable dosages over time (12.0-20.4 mg/d for @entity9 and 11.5-22.0 mg/d for OXN). Bowel Function Index (BFI) and laxative use per week improved from baseline at 30 days and 60 days in OXN recipients (-16, P<0.0001 and -3.5, P=0.02, respectively); BFI worsened in the @entity9 group. The overall incidence of drug-related adverse events was 28.9% in the @entity9 group and 8.2% in the OXN group (P<0.01); @entity3 and @entity4 were two to five times less frequent with OXN. Quality of life improved to a significantly greater extent in @entity0 receiving OXN compared to @entity9 (increase in Short Form-36 physical component score of 7.1 points vs 3.2 points, respectively; P<0.001). CONCLUSION: In @entity0 with chronic @entity1 , OXN provided analgesic effectiveness that is similar to @entity9 , with early and sustained benefits in tolerability. The relationship between responsiveness to OXN and clinical characteristics is currently being investigated.

title: Efficacy and tolerability of oral @entity6 and XXXX / @entity8 combination in opioid-na  ve @entity1 @entity0 : a propensity analysis.

answer: @entity6


abstract: INTRODUCTION: @entity3 is a rare event. While the most frequent symptom is @entity2 , that is a common @entity1 ( @entity1 ) chief complaint and other diseases causing @entity2 occur much more often. Furthermore, 20% of dissections are without @entity2 and 6% are painless. For these reasons, diagnosing dissections may be challenging. Our goal was to determine the number of total @entity1 and atraumatic @entity2 @entity0 for every aortic dissection diagnosed by emergency physicians. METHODS:                 <AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective cohort. SETTING: 33 suburban and urban New York and New Jersey EDs with annual visits between 8,000 and 80,000. @entity0 : Consecutive @entity0 seen by emergency physicians from 1-1-1996 through 12-31-2010. OBSERVATIONS: We identified aortic dissection and atraumatic @entity2 @entity0 using the International Classification of Diseases 9(th) Revision and Clinical Modification codes. We then calculated the number of total @entity1 and atraumatic @entity2 @entity0 for every aortic dissection, along with 95% confidence intervals (CIs). RESULTS: From a database of 9.5 million @entity1 visits, we identified 782 @entity3 or one for every 12,200 (95% CI [11,400-13,100]) visits. The mean age of dissection @entity0 was 66  16 years and 38% were female. There were 763,000 (8%) with atraumatic @entity2 diagnoses. Thus, there is one dissection for every 980 (95% CI [910-1,050]) atraumatic @entity2 @entity0 . CONCLUSION: The diagnosis of @entity3 by emergency physicians is rare and challenging. An emergency physician seeing 3,000 to 4,000 @entity0 a year would diagnose an aortic dissection approximately every three to four years.

title: Diagnosis of XXXX in Emergency Department @entity0 is Rare.

answer: @entity3


abstract: INTRODUCTION: @entity3 is a rare event. While the most frequent symptom is @entity2 , that is a common @entity1 ( @entity1 ) chief complaint and other diseases causing @entity2 occur much more often. Furthermore, 20% of dissections are without @entity2 and 6% are painless. For these reasons, diagnosing dissections may be challenging. Our goal was to determine the number of total @entity1 and atraumatic @entity2 @entity0 for every aortic dissection diagnosed by emergency physicians. METHODS:                 <AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective cohort. SETTING: 33 suburban and urban New York and New Jersey EDs with annual visits between 8,000 and 80,000. @entity0 : Consecutive @entity0 seen by emergency physicians from 1-1-1996 through 12-31-2010. OBSERVATIONS: We identified aortic dissection and atraumatic @entity2 @entity0 using the International Classification of Diseases 9(th) Revision and Clinical Modification codes. We then calculated the number of total @entity1 and atraumatic @entity2 @entity0 for every aortic dissection, along with 95% confidence intervals (CIs). RESULTS: From a database of 9.5 million @entity1 visits, we identified 782 @entity3 or one for every 12,200 (95% CI [11,400-13,100]) visits. The mean age of dissection @entity0 was 66  16 years and 38% were female. There were 763,000 (8%) with atraumatic @entity2 diagnoses. Thus, there is one dissection for every 980 (95% CI [910-1,050]) atraumatic @entity2 @entity0 . CONCLUSION: The diagnosis of @entity3 by emergency physicians is rare and challenging. An emergency physician seeing 3,000 to 4,000 @entity0 a year would diagnose an aortic dissection approximately every three to four years.

title: Diagnosis of @entity3 in Emergency Department XXXX is Rare.

answer: @entity0


abstract: In monkeys anesthetized with 70% @entity5 and 0.5% inspired @entity3 in @entity0 , we measured changes in systemic hemodynamics and regional blood flows produced by @entity4 and @entity6 . Regional blood flow measurements were made using the radioactive microsphere technique. Control measurements were made before infusion of @entity4 and @entity6 into each animal in sequence in amounts adequate to reduce mean arterial pressure to approximately 55 +/- 5 mm Hg. Measurements were made during each drug infusion after a stable period of @entity2 lasting at least 30 min. During @entity4 infusion, cerebral blood flow remained unchanged, but myocardial blood flow increased significantly. However, pressure-rate product, an indirect measure of myocardial @entity0 consumption, was unchanged, implying that myocardial blood flow exceeded myocardial @entity0 requirement. During @entity6 infusion, cerebral blood flow decreased, although cerebral metabolic rate for @entity0 was unchanged due to increased @entity0 extraction by the brain. @entity6 also produced a decrease in myocardial blood flow that was in proportion to the decrease in myocardial @entity0 requirement as indicated by pressure-rate product. Neither drug produced changes in @entity1 . We conclude that brain @entity0 reserve is decreased during @entity2 induced by @entity6 . Blood flows to other organs are not significantly impaired in monkeys during @entity2 to a mean arterial pressure of approximately 55 mm Hg induced by either @entity4 or @entity6 .

title: Regional blood flows during induced @entity2 produced by XXXX or @entity6 in the rhesus monkey.

answer: @entity4


abstract: In monkeys anesthetized with 70% @entity5 and 0.5% inspired @entity3 in @entity0 , we measured changes in systemic hemodynamics and regional blood flows produced by @entity4 and @entity6 . Regional blood flow measurements were made using the radioactive microsphere technique. Control measurements were made before infusion of @entity4 and @entity6 into each animal in sequence in amounts adequate to reduce mean arterial pressure to approximately 55 +/- 5 mm Hg. Measurements were made during each drug infusion after a stable period of @entity2 lasting at least 30 min. During @entity4 infusion, cerebral blood flow remained unchanged, but myocardial blood flow increased significantly. However, pressure-rate product, an indirect measure of myocardial @entity0 consumption, was unchanged, implying that myocardial blood flow exceeded myocardial @entity0 requirement. During @entity6 infusion, cerebral blood flow decreased, although cerebral metabolic rate for @entity0 was unchanged due to increased @entity0 extraction by the brain. @entity6 also produced a decrease in myocardial blood flow that was in proportion to the decrease in myocardial @entity0 requirement as indicated by pressure-rate product. Neither drug produced changes in @entity1 . We conclude that brain @entity0 reserve is decreased during @entity2 induced by @entity6 . Blood flows to other organs are not significantly impaired in monkeys during @entity2 to a mean arterial pressure of approximately 55 mm Hg induced by either @entity4 or @entity6 .

title: Regional blood flows during induced XXXX produced by @entity4 or @entity6 in the rhesus monkey.

answer: @entity2


abstract: In monkeys anesthetized with 70% @entity5 and 0.5% inspired @entity3 in @entity0 , we measured changes in systemic hemodynamics and regional blood flows produced by @entity4 and @entity6 . Regional blood flow measurements were made using the radioactive microsphere technique. Control measurements were made before infusion of @entity4 and @entity6 into each animal in sequence in amounts adequate to reduce mean arterial pressure to approximately 55 +/- 5 mm Hg. Measurements were made during each drug infusion after a stable period of @entity2 lasting at least 30 min. During @entity4 infusion, cerebral blood flow remained unchanged, but myocardial blood flow increased significantly. However, pressure-rate product, an indirect measure of myocardial @entity0 consumption, was unchanged, implying that myocardial blood flow exceeded myocardial @entity0 requirement. During @entity6 infusion, cerebral blood flow decreased, although cerebral metabolic rate for @entity0 was unchanged due to increased @entity0 extraction by the brain. @entity6 also produced a decrease in myocardial blood flow that was in proportion to the decrease in myocardial @entity0 requirement as indicated by pressure-rate product. Neither drug produced changes in @entity1 . We conclude that brain @entity0 reserve is decreased during @entity2 induced by @entity6 . Blood flows to other organs are not significantly impaired in monkeys during @entity2 to a mean arterial pressure of approximately 55 mm Hg induced by either @entity4 or @entity6 .

title: Regional blood flows during induced @entity2 produced by @entity4 or XXXX in the rhesus monkey.

answer: @entity6


abstract: @entity4 has been detected in nine unrelated, commercial rabbitries. During the acute stage of the disease, recently weaned @entity2 showed profuse watery @entity5 . Mortality was between 14.2 and 41.2% during the first three weeks of the outbreaks. In surviving animals, there was a chronic evolution with @entity7 , @entity8 , loss of weight and sometimes extreme @entity10 . Reproduction animals were less badly affected. Multifocal @entity3 , focal @entity6 , patches of @entity1 in ileum, caecum and colon and marked caecal @entity0 were most prominent at autopsy. In histological sections of the liver, bundles of slightly Gram-negative and Giemsa-, PAS- and @entity9 -positive rod-shaped bacilli were established in apparently viable hepatocytes bordering foci of @entity1 . They were also present in myocytes around @entity1 foci in the heart and in enterocytes and smooth muscle cells of the muscularis mucosae of the intestinal mucosa. Transmission electron microscopy showed that these organisms had a similar ultrastructure as Bacillus piliformis. Most antibiotics used failed to combat the disease. Only @entity11 was active.

title: Naturally-occurring @entity4 (Bacillus piliformis infection) in commercial XXXX : a clinical and pathological study.

answer: @entity2


abstract: @entity4 has been detected in nine unrelated, commercial rabbitries. During the acute stage of the disease, recently weaned @entity2 showed profuse watery @entity5 . Mortality was between 14.2 and 41.2% during the first three weeks of the outbreaks. In surviving animals, there was a chronic evolution with @entity7 , @entity8 , loss of weight and sometimes extreme @entity10 . Reproduction animals were less badly affected. Multifocal @entity3 , focal @entity6 , patches of @entity1 in ileum, caecum and colon and marked caecal @entity0 were most prominent at autopsy. In histological sections of the liver, bundles of slightly Gram-negative and Giemsa-, PAS- and @entity9 -positive rod-shaped bacilli were established in apparently viable hepatocytes bordering foci of @entity1 . They were also present in myocytes around @entity1 foci in the heart and in enterocytes and smooth muscle cells of the muscularis mucosae of the intestinal mucosa. Transmission electron microscopy showed that these organisms had a similar ultrastructure as Bacillus piliformis. Most antibiotics used failed to combat the disease. Only @entity11 was active.

title: Naturally-occurring XXXX (Bacillus piliformis infection) in commercial @entity2 : a clinical and pathological study.

answer: @entity4


abstract: INTRODUCTION: @entity4 carries a high mortality and necessitates intervention to achieve @entity1 control. The surgical strategy for proven infected @entity0 has evolved, with abandonment of open necrosectomy to a step-up approach consisting of percutaneous drains and @entity5 ( @entity5 ). We present a case that underwent @entity5 complicated by @entity2 and @entity3 and describe its management. PRESENTATION OF CASE: A 38 year-old male with acute @entity4 developed @entity4 . Initial treatment was by percutaneous drainage under radiological guidance and intravenous antibiotics. The @entity0 was then debrided using gasless laparoscopy through a mini-incision. Post-operatively, he developed @entity2 which was controlled with angioembolisation. He also developed a descending @entity3 which was treated with laparotomy and defunctioning loop ileostomy. He recovered and subsequently had his ileostomy closed twelve months later. The @entity3 recurred and was treated with endoscopic clips and histoacryl glue injection and finally closed. DISCUSSION: Step-up approach consists of the 3 D's: Delay, drain and debride. @entity5 is recommended as it is replicable in general surgical units using standard laparoscopic instruments. Bleeding and colon perforation are potential complications which must have multi-disciplinary input, aggressive resuscitation and timely radiologic intervention. Defunctioning ileostomy is recommended to control @entity1 in @entity3 . Novel fistula closing methods using endoscopic clips and histoacryl glue are potential treatment options. CONCLUSION: Step-up approach and @entity5 is the new paradigm to treat @entity4 . Complications of @entity2 and @entity3 are uncommon and require multi-disciplinary management.

title: Step-up approach and video assisted retroperitoneal debridement in XXXX : A case complicated by retroperitoneal @entity2 and @entity3 .

answer: @entity4


abstract: INTRODUCTION: @entity4 carries a high mortality and necessitates intervention to achieve @entity1 control. The surgical strategy for proven infected @entity0 has evolved, with abandonment of open necrosectomy to a step-up approach consisting of percutaneous drains and @entity5 ( @entity5 ). We present a case that underwent @entity5 complicated by @entity2 and @entity3 and describe its management. PRESENTATION OF CASE: A 38 year-old male with acute @entity4 developed @entity4 . Initial treatment was by percutaneous drainage under radiological guidance and intravenous antibiotics. The @entity0 was then debrided using gasless laparoscopy through a mini-incision. Post-operatively, he developed @entity2 which was controlled with angioembolisation. He also developed a descending @entity3 which was treated with laparotomy and defunctioning loop ileostomy. He recovered and subsequently had his ileostomy closed twelve months later. The @entity3 recurred and was treated with endoscopic clips and histoacryl glue injection and finally closed. DISCUSSION: Step-up approach consists of the 3 D's: Delay, drain and debride. @entity5 is recommended as it is replicable in general surgical units using standard laparoscopic instruments. Bleeding and colon perforation are potential complications which must have multi-disciplinary input, aggressive resuscitation and timely radiologic intervention. Defunctioning ileostomy is recommended to control @entity1 in @entity3 . Novel fistula closing methods using endoscopic clips and histoacryl glue are potential treatment options. CONCLUSION: Step-up approach and @entity5 is the new paradigm to treat @entity4 . Complications of @entity2 and @entity3 are uncommon and require multi-disciplinary management.

title: Step-up approach and video assisted retroperitoneal debridement in @entity4 : A case complicated by retroperitoneal @entity2 and XXXX .

answer: @entity3


abstract: INTRODUCTION: @entity4 carries a high mortality and necessitates intervention to achieve @entity1 control. The surgical strategy for proven infected @entity0 has evolved, with abandonment of open necrosectomy to a step-up approach consisting of percutaneous drains and @entity5 ( @entity5 ). We present a case that underwent @entity5 complicated by @entity2 and @entity3 and describe its management. PRESENTATION OF CASE: A 38 year-old male with acute @entity4 developed @entity4 . Initial treatment was by percutaneous drainage under radiological guidance and intravenous antibiotics. The @entity0 was then debrided using gasless laparoscopy through a mini-incision. Post-operatively, he developed @entity2 which was controlled with angioembolisation. He also developed a descending @entity3 which was treated with laparotomy and defunctioning loop ileostomy. He recovered and subsequently had his ileostomy closed twelve months later. The @entity3 recurred and was treated with endoscopic clips and histoacryl glue injection and finally closed. DISCUSSION: Step-up approach consists of the 3 D's: Delay, drain and debride. @entity5 is recommended as it is replicable in general surgical units using standard laparoscopic instruments. Bleeding and colon perforation are potential complications which must have multi-disciplinary input, aggressive resuscitation and timely radiologic intervention. Defunctioning ileostomy is recommended to control @entity1 in @entity3 . Novel fistula closing methods using endoscopic clips and histoacryl glue are potential treatment options. CONCLUSION: Step-up approach and @entity5 is the new paradigm to treat @entity4 . Complications of @entity2 and @entity3 are uncommon and require multi-disciplinary management.

title: Step-up approach and video assisted retroperitoneal debridement in @entity4 : A case complicated by retroperitoneal XXXX and @entity3 .

answer: @entity2


abstract: UNASSIGNED: Objectives. The present study was done to evaluate birefringence pattern of collagen fibres in different grades of @entity1 using Picrosirius red stain and polarization microscopy and to determine if there is a change in collagen fibres between different grades of @entity1 . Materials and Methods. Picrosirius red stained 5    m thick sections of previously diagnosed different grades of @entity1 and normal oral mucosa were studied under polarization microscopy for arrangement as well as birefringence of collagen fibres around @entity0 islands. Results. It was found that thin collagen fibres increased and thick collagen fibres decreased with dedifferentiation of OSCC (P < 0.0001). It was observed that there was change in polarization colours of thick fibres from yellowish orange to greenish yellow with dedifferentiation of OSCC indicating loosely packed fibres (P < 0.0001). Conclusion. There was a gradual change of birefringence of collagen from yellowish orange to greenish yellow from well to poorly differentiated @entity1 , indicating that there is a change from mature form of collagen to immature form as @entity0 progresses. Studying collagen fibres with Picrosirius red for stromal changes around @entity0 islands along with routine staining may help in predicting the prognosis of @entity0 .

title: Study of Collagen Birefringence in Different Grades of XXXX Using Picrosirius Red and Polarized Light Microscopy.

answer: @entity1


abstract: BACKGROUND: Habit of consuming @entity1 and areca-nut containing substances is in vogue in Lucknow as a part of the Nawabi culture. Hence, this study was planned with an aim to generate evidence for the prevalence of habits of @entity2 by the population of Lucknow and know their socio-demographic profile. METHODOLOGY: Population based cross-sectional study was conducted by organizing oral health check-up camps in randomly selected rural and urban parts of Lucknow, the capital city of Uttar Pradesh, which is the most populated state of India. @entity0 were enrolled after obtaining informed consent. A structured and validated questionnaire based tool was administered by a team of trained dental surgeons for collecting the desired information through interview and their oral cavity examination. RESULTS: A total of 3437 subjects were enrolled in the study, out of which 82.9% were male and 17.1% were female. Among them, 64.6% subjects belonged to rural domiciliary status, by religion, 80.6% and 18.5% of the subjects were Hindu and Muslims respectively. The most prevalent habit was consumption of smokeless @entity1 substances, of which pan masala with @entity1 (gutkha) was the most prevalent substance of abuse. CONCLUSION: Smokeless @entity1 consumption was highly prevalent in the population surveyed. It is recommended to formulate and implement strong preventive strategies. Also, steps should be taken to increase the awareness of the harmful consequences of these habits.

title: Epidemiology of XXXX in the population of Lucknow.

answer: @entity2


abstract: @entity3 (Dha/ @entity3 ) is a homeodomain protein containing an Engrailed homology (Eh) 1 repressor motif. It is important in @entity1 dorsal organizer formation. Dha/ @entity3 interacted with a co-repressor Groucho through the Eh1 motif. Expression of a Dha/ @entity3 fused to the transcriptional activator @entity0 repressed dorsal axis formation and the expression of organizer genes but led to the dorsal expansion of expression of the homeobox gene vox/ @entity4 , indicating that Dha/ @entity3 functions as a transcriptional repressor for dorsal axis formation. We also isolated a novel homeobox gene, ved, whose expression was negatively regulated by dha/ @entity3 . ved's sequence and expression profile were similar to those of vox/ @entity4 and @entity2 / @entity2 . Like Vox/ @entity4 and @entity2 / @entity2 , Ved acted as a transcriptional repressor. The combined inhibition of ved, vox/ @entity4 , and @entity2 / @entity2 , by antisense morpholino injection, strongly dorsalized the embryos and elicited ventral expansion of organizer gene expression, compared with the effect of inhibiting each of these genes alone. These results suggest that ved is a target for the repressor Dha/ @entity3 . Ved functions redundantly with vox/ @entity4 and @entity2 / @entity2 to restrict the organizer domain.

title: A novel repressor-type homeobox gene, ved, is involved in @entity3 / @entity3 -mediated dorsal organizer formation in XXXX .

answer: @entity1


abstract: @entity3 (Dha/ @entity3 ) is a homeodomain protein containing an Engrailed homology (Eh) 1 repressor motif. It is important in @entity1 dorsal organizer formation. Dha/ @entity3 interacted with a co-repressor Groucho through the Eh1 motif. Expression of a Dha/ @entity3 fused to the transcriptional activator @entity0 repressed dorsal axis formation and the expression of organizer genes but led to the dorsal expansion of expression of the homeobox gene vox/ @entity4 , indicating that Dha/ @entity3 functions as a transcriptional repressor for dorsal axis formation. We also isolated a novel homeobox gene, ved, whose expression was negatively regulated by dha/ @entity3 . ved's sequence and expression profile were similar to those of vox/ @entity4 and @entity2 / @entity2 . Like Vox/ @entity4 and @entity2 / @entity2 , Ved acted as a transcriptional repressor. The combined inhibition of ved, vox/ @entity4 , and @entity2 / @entity2 , by antisense morpholino injection, strongly dorsalized the embryos and elicited ventral expansion of organizer gene expression, compared with the effect of inhibiting each of these genes alone. These results suggest that ved is a target for the repressor Dha/ @entity3 . Ved functions redundantly with vox/ @entity4 and @entity2 / @entity2 to restrict the organizer domain.

title: A novel repressor-type homeobox gene, ved, is involved in XXXX / @entity3 -mediated dorsal organizer formation in @entity1 .

answer: @entity3


abstract: @entity3 (Dha/ @entity3 ) is a homeodomain protein containing an Engrailed homology (Eh) 1 repressor motif. It is important in @entity1 dorsal organizer formation. Dha/ @entity3 interacted with a co-repressor Groucho through the Eh1 motif. Expression of a Dha/ @entity3 fused to the transcriptional activator @entity0 repressed dorsal axis formation and the expression of organizer genes but led to the dorsal expansion of expression of the homeobox gene vox/ @entity4 , indicating that Dha/ @entity3 functions as a transcriptional repressor for dorsal axis formation. We also isolated a novel homeobox gene, ved, whose expression was negatively regulated by dha/ @entity3 . ved's sequence and expression profile were similar to those of vox/ @entity4 and @entity2 / @entity2 . Like Vox/ @entity4 and @entity2 / @entity2 , Ved acted as a transcriptional repressor. The combined inhibition of ved, vox/ @entity4 , and @entity2 / @entity2 , by antisense morpholino injection, strongly dorsalized the embryos and elicited ventral expansion of organizer gene expression, compared with the effect of inhibiting each of these genes alone. These results suggest that ved is a target for the repressor Dha/ @entity3 . Ved functions redundantly with vox/ @entity4 and @entity2 / @entity2 to restrict the organizer domain.

title: A novel repressor-type homeobox gene, ved, is involved in @entity3 / XXXX -mediated dorsal organizer formation in @entity1 .

answer: @entity3


abstract: BACKGROUND: High prevalence and increasing rate of @entity2 @entity0 around the word witnesses the high burden of @entity1 . We have limited data on @entity1 burden and economic costs in Iran. This study aimed to find direct and indirect economic costs of @entity1 and their association with some background factors in one of the referral tertiary centers for adult @entity0 with @entity1 . METHODS: We surveyed @entity1 related economic costs of 197 adult @entity0 who referred to Milad Hospital, Tehran, Iran from @entity3 2007 to January 2010. The @entity0 were followed up for a period of one-year   1 month and @entity1 related costs and its control status were registered. RESULTS: @entity0 were consisted of 125 (64.1%) females and 70 (35.9%) males. Total cost of @entity1 was 590.22   32.18 USD for one @entity0 per one year, the cost of drug, paraclinic, doctor visit, hospitalization, emergency, transportation, and absent days were 327.02, 4.76, 35.44, 3.82, 0.26, 113.03, 105.89 USD respectively. @entity0 showed a significant elevation in their total (P=0.009) and drug costs (P=0.028). In addition, we found significant differences between total @entity1 costs and @entity1 control status (P=0.002). CONCLUSIONS: According to the high proportion of @entity1 , related cost compare to Total Income of an Iranian family, the necessity of public coverage of health assurance is quite clear. We suggest that improving @entity1 management and accessibility to specialized treatment centers can result in decreasing @entity1 medication and transportation costs as major direct and indirect @entity1 related costs.

title: Asthma Economic Costs in Adult Asthmatic XXXX in Tehran, Iran.

answer: @entity0


abstract: A QTL analysis of behavioral and neuroendocrine responses to a "novel environment" stress was conducted in a three-generation experimental cross between Meishan and Large White @entity3 breeds. A total of 186 F2 males and 182 F2 females were studied for their behavioral and neuroendocrine reactivity to a novel environment test at 6 wk of age. Locomotion, vocalization, and defecation rate, as well as exploration time, were measured for 10 min. Blood samples were taken immediately before and after the test to measure plasma levels of ACTH, @entity1 , and @entity0 . Animals were typed for a total of 137 markers covering the entire porcine genome. Analyses were performed using two interval mapping methods: a line-cross regression method, where founder lines were assumed to be fixed for different QTL alleles, and a half-/full-sib maximum likelihood method where allele substitution effects were estimated within each half-/full-sib family. Both methods revealed a highly significant gene effect for poststress @entity1 level (P < 0.001) and a significant effect for basal @entity1 level (P < 0.05) at the end of the q arm of chromosome 7, explaining, respectively, 20% and 7% of the phenotypic variance. Meishan alleles are associated with higher @entity1 levels and are partially dominant (for poststress levels) over Large White alleles. Other significant gene effects on biological measures were detected on chromosomes 1 and 17 (ACTH response to stress), 3, 5, and 8 ( @entity0 levels). The SSC 17 QTL explains 12% of the phenotypic variance of poststress ACTH levels, with a suggestive evidence of imprinting effects. Meishan alleles are associated with lower poststress ACTH levels. Gene effects of low amplitude only were found for behavioral reactivity traits. Considering the effects of stress neuroendocrine systems on energy fluxes and @entity2 , and the importance of stress reactivity for meat quality and animal welfare, these results open new perspectives for @entity3 selection.

title: Genetic linkage mapping of quantitative trait loci for behavioral and neuroendocrine stress response traits in XXXX .

answer: @entity3


abstract: Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for treatment of otherwise incurable malignant and non-malignant diseases. Until recently, autologous and allogeneic bone marrow or mobilized blood stem cells transplantation were used primarily to replace malignant, genetically abnormal or deficient immunohematopoietic compartment and therefore, highly toxic myeloablative regimen were considered mandatory for more effective eradication of all undesirable host-derived hematopoietic elements. Our preclinical and ongoing clinical studies indicated that much more effective eradication of host immunohematopoietic system cells could be achieved by adoptive allogeneic cell therapy with donor lymphocyte infusion following BMT. Thus, eradication of @entity1 cells, especially in @entity0 with @entity5 and less frequently in @entity0 with other @entity3 , could be frequently accomplished despite complete resistance of such @entity1 cells to maximally tolerated doses of chemoradiotherapy. Our cumulative experience suggested that graft versus @entity4 (GVL) effects might be a useful tool for eradication of otherwise resistant @entity1 cells of host origin. Based on the cumulative clinical experience and experimental data in animal models of @entity0 diseases it appears that induction of host versus graft tolerance as step one, may allow durable engraftment of donor immunocompetent lymphocytes, which may be used for induction of effective biologic warfare against host-type immunohematopoietic cells that need to be replaced, malignant, genetically abnormal or self-reactive alike. Based on the aforementioned rationale, we speculated that the therapeutic benefit of BMT may be improved by using a safer conditioning as part of the transplant procedure, with the goal in mind to induce host versus graft tolerance to enable subsequent induction of GVL, possibly graft versus @entity1 or even graft versus autoimmunity effects, rather than attempt to eliminate host cells with hazardous myeloablative chemoradiotherapy. The latter hypothesis suggested that effective BMT procedure may be accomplished without lethal conditioning of the host, using new well tolerated non-myeloablative regimen, thus possibly minimizing immediate and late side effects related to myeloablative procedures considered until recently mandatory for conditioning of BMT recipients. Recent clinical data that will be presented suggests that effective BMT procedures may be accomplished with well-tolerated non-myeloablative stem cell transplantation (NST) regimen, with no major @entity2 . Thus, new NST approaches may offer the feasibility of safer BMT procedure for a large spectrum of clinical indications in @entity0 and elderly individuals without lower or upper age limit, while minimizing procedure-related @entity2 and mortality. Taken together, our cumulative data suggest that high dose chemotherapy and radiation therapy may be successively replaced by a more effective biologic tool, alloreactive donor lymphocytes, thus setting the stage for innovative therapeutic procedures for safer and more effective treatment of @entity0 in need of BMT.

title: Non-myeloablative stem cell transplantation for the treatment of XXXX and life-threatening non-malignant disorders; past accomplishments and future goals.

answer: @entity1


abstract: OBJECTIVES: The objective of this study was to assess the sensitivity of motor-evoked potentials (MEPs) elicited by @entity4 ( @entity4 ) in demonstrating the possible subclinical impairment of the corticospinal pathway after recovery, in @entity0 with a clinical history of @entity1 ( @entity1 ) due to a single lacunar infarct detectable by magnetic resonance imaging (MRI). METHODS: MEPs were recorded from the first dorsal interosseous muscle of 20 healthy subjects and 40 @entity0 , 6 months or more after @entity1 onset. @entity0 were evaluated clinically by means of the @entity1 scale, the Medical Research Council (MRC) scale and the Barthel Index. The @entity0 with full hand strength recovery and the normal controls were also tested by means of the 9-hole peg test. RESULTS: Motor threshold (MT), MEP amplitude and @entity2 ( @entity2 ) of the affected side were significantly different from those of the normal side and of the control subjects. MT, MEP amplitude and @entity2 obtained after stimulation of the affected hemisphere were significantly correlated with the MRC scale values of the affected hand. Eighty-six percent of @entity0 with persistent hand strength deficit showed @entity3 . In 21 @entity0 with complete clinical recovery, a significant increase in MT and decrease in MEP amplitude on the affected side were observed. CONCLUSIONS: After @entity1 , neurophysiological changes may persist despite complete clinical recovery. @entity4 represents a sensitive tool that enables to demonstrate objectively the clinical and subclinical impairment of the corticospinal pathway.

title: Transcranial magnetic stimulation after XXXX .

answer: @entity1


abstract: Some @entity0 with @entity1 exhibit late-phase responses to inhalation challenge with specific antigen. However, the duration of these responses is difficult to determine because of diurnal variations in airway function, a common phenomenon in @entity0 with @entity3 . We therefore examined the pattern and duration of pulmonary function in six asymptomatic @entity0 with a history of ragweed @entity3 and a documented late-phase response after specific and nonspecific bronchial challenge and compared them to responses after control challenge with normal saline. On 3 different days, specific airway conductance (SGaw) and gas distribution by the single breath @entity4 test were measured before (9:00 A.M.) and hourly for 24 hours after inhalation challenge with either normal saline, ragweed extract, or @entity2 at concentrations sufficient to decrease SGaw immediately by 35% or more. The fluctuations in SGaw after saline and @entity2 were considerable but failed to follow a typical diurnal or biphasic pattern. There was no difference in mean SGaw between the @entity2 and saline challenges from 1 to 24 hours after inhalation. In contrast, ragweed challenge produced a typical late-phase response followed by partial recovery of mean SGaw. However, mean SGaw remained subsequently lower than after saline challenge throughout the remaining observation period with fluctuations about this lower level. Gas distribution demonstrated marked intra- and intersubject variations and was therefore not different among the three challenges at any time of measurement. These observations suggest that a single specific but not nonspecific bronchial challenge causes prolonged airflow obstruction in subjects with @entity1 that lasts 24 hours or longer, independent of variations in baseline airway function.

title: Prolonged bronchial obstruction after a single antigen challenge in ragweed XXXX .

answer: @entity3


abstract: The interaction between immune aggregates and complement (C) was investigated. Solid-phase immune aggregates were prepared by coating microwells with heat-aggregated bovine serum albumin (BSA) followed by rabbit anti-BSA antibody. The immune aggregates were reacted with human serum or citrated plasma at 37 degrees C. The binding of C3 components was investigated with biotinylated F(ab')2 antibodies to C3c and @entity6 and avidin-coupled alkaline phosphatase. The form of the incorporated C3, whether @entity4 -iC3b or C3dg, can be deduced from the response with these two antibodies. The maximal binding of @entity4 -iC3b to the immune aggregates was observed within 5 min of incubation with serum or citrated plasma. The conversion to C3dg was evident by a decrease in bound anti-C3c concomitant with increasing anti- @entity6 reactivity within about 10 min of incubation. When the classical C pathway activation was inhibited, the binding of @entity4 -iC3b was delayed by 20-30 min, whereas stopping of the alternative pathway did not influence the initial kinetics of the reaction. The addition of @entity0 red blood cells had no measurable influence on the degradation of bound @entity4 -iC3b. 125I-labelled anti-BSA antibody bound to the solid-phase BSA was not released during the C3 incorporation. The incorporation of @entity4 into the immune aggregates was mediated equally well by serum and by citrated plasma. The incorporation of @entity4 -iC3b into @entity5 ( @entity5 ) is thought to be responsible for the C-mediated solubilization (CMS) of @entity5 . Citrated plasma, however, exerted no CMS capacity when measured by a radiometric assay. The CMS capacity of serum was inhibited by @entity3 , but could then be restored by adding @entity1 and @entity2 , whereas no CMS could be demonstrated with citrated plasma to which divalent metal ions were added.

title: The attachment of serum- and plasma-derived C3 to solid-phase immune aggregates and its relation to complement-mediated solubilization of XXXX .

answer: @entity5


abstract: PURPOSE: Median survival in advanced @entity1 @entity0 treated with @entity3 (5FU) and @entity5 (LV) is between 12 and 18 months. The aim of this study was to evaluate long term survival in this disease. METHODS: We report here, retrospectively, the survival of 445 @entity0 who entered in first-line prospective studies with LV-5FU-based regimen chemotherapy, between 1985 and 1995. RESULTS: Median survival was 18 months. The 3, 5 and 10 year survival were respectively 17.9%, 4.5% and 2.4%. Seventy-five @entity0 survived more than 3 years, among them, 10 achieved a complete and 34 a partial response, 12 had curative liver or lung surgery. Fifteen @entity0 lived more than 5 years, 2 achieved a complete and 7 a partial response. Seven had curative surgery. Eleven @entity0 were still alive in 2002, among them 7 in complete remission at 5 years, including 3 who did not have surgery. CONCLUSION: This study shows that some @entity0 with metastatic @entity1 can achieve long survival, especially when secondary curative surgery can be performed. However, 1% of the @entity0 can be cured with LV-5FU chemotherapy alone. These results will be probably improve with the use of the new drugs: @entity2 and @entity4 .

title: [Long term survival in metastatic @entity1 treated with XXXX and @entity3 chemotherapy].

answer: @entity5


abstract: PURPOSE: Median survival in advanced @entity1 @entity0 treated with @entity3 (5FU) and @entity5 (LV) is between 12 and 18 months. The aim of this study was to evaluate long term survival in this disease. METHODS: We report here, retrospectively, the survival of 445 @entity0 who entered in first-line prospective studies with LV-5FU-based regimen chemotherapy, between 1985 and 1995. RESULTS: Median survival was 18 months. The 3, 5 and 10 year survival were respectively 17.9%, 4.5% and 2.4%. Seventy-five @entity0 survived more than 3 years, among them, 10 achieved a complete and 34 a partial response, 12 had curative liver or lung surgery. Fifteen @entity0 lived more than 5 years, 2 achieved a complete and 7 a partial response. Seven had curative surgery. Eleven @entity0 were still alive in 2002, among them 7 in complete remission at 5 years, including 3 who did not have surgery. CONCLUSION: This study shows that some @entity0 with metastatic @entity1 can achieve long survival, especially when secondary curative surgery can be performed. However, 1% of the @entity0 can be cured with LV-5FU chemotherapy alone. These results will be probably improve with the use of the new drugs: @entity2 and @entity4 .

title: [Long term survival in metastatic XXXX treated with @entity5 and @entity3 chemotherapy].

answer: @entity1


abstract: PURPOSE: Median survival in advanced @entity1 @entity0 treated with @entity3 (5FU) and @entity5 (LV) is between 12 and 18 months. The aim of this study was to evaluate long term survival in this disease. METHODS: We report here, retrospectively, the survival of 445 @entity0 who entered in first-line prospective studies with LV-5FU-based regimen chemotherapy, between 1985 and 1995. RESULTS: Median survival was 18 months. The 3, 5 and 10 year survival were respectively 17.9%, 4.5% and 2.4%. Seventy-five @entity0 survived more than 3 years, among them, 10 achieved a complete and 34 a partial response, 12 had curative liver or lung surgery. Fifteen @entity0 lived more than 5 years, 2 achieved a complete and 7 a partial response. Seven had curative surgery. Eleven @entity0 were still alive in 2002, among them 7 in complete remission at 5 years, including 3 who did not have surgery. CONCLUSION: This study shows that some @entity0 with metastatic @entity1 can achieve long survival, especially when secondary curative surgery can be performed. However, 1% of the @entity0 can be cured with LV-5FU chemotherapy alone. These results will be probably improve with the use of the new drugs: @entity2 and @entity4 .

title: [Long term survival in metastatic @entity1 treated with @entity5 and XXXX chemotherapy].

answer: @entity3


abstract: INTRODUCTION: @entity1 involves large vessels in 15% of cases. Their discovery is usually late, commonly several years after the diagnosis. EXEGESIS: We describe three cases of @entity1 with thoracic aorta involvement: two @entity0 presented with @entity4 which revealed @entity1 , one @entity0 had @entity3 . Clinical features of @entity1 were absent in two @entity0 . Temporal artery biopsy, performed in two cases, was positive. Two @entity0 were treated with @entity2 , associated in one case with immunosuppressive agent. Surgery was necessary in all @entity0 . CONCLUSION: Thoracic aorta involvement in @entity1 is most often discovered when corticotherapy is decreased. @entity6 or @entity5 in aortic affection are the major complication. @entity0 with thoracic aorta involvement need a clinical and radiological follow up over long period.

title: [Involvement of thoracic aorta revealing XXXX . Three cases].

answer: @entity1


abstract: Precocious first ovulation, preceded by an endogenous preovulatory LH surge, could be predictably induced in immature female @entity1 by administering repeated injections of @entity0 chorionic gonadotrophin ( @entity2 ). Administration of a dose of 0.05-0.075 i.u. @entity2 , four times a day from day 28 to day 31 of age resulted in a highly constant ovulatory response: at 4.0 +/- 0.0 days after the start of treatment 7.7 +/- 0.3 (n = 15) ova were found. Use of a higher dose of @entity2 (0.1 i.u.) resulted in lower numbers of ova (5.6 +/- 0.4, n = 7; P less than 0.005) whereas use of a lower dose of @entity2 (0.025-0.038 i.u.) resulted in a less constant timing of the induced ovulation at 5.4 +/- 0.2 days after the start of treatment (n = 7; P less than 0.0005). In animals treated with the dose of 0.05-0.075 i.u. @entity2 , a positive correlation was found between body weight at the start of treatment and the number of ova released (r = 0.75, n = 25; P less than 0.001). Ovarian follicle dynamics were studied on the various days of @entity2 treatment (dose 0.05-0.075 i.u.) and compared with the follicle changes that take place after electrical stimulation of the hypothalamus, performed on day 28, a treatment known to result in first ovulation 4-5 days later. In both groups a decrease in the number of the smallest and the middle-sized antral follicles as compared with their respective controls was seen, whereas numbers of follicles in the largest, 'ovulatable' size classes gradually increased.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Precocious ovulation induced by XXXX chorionic gonadotrophin in the immature female @entity1 : comparison of follicle growth induced by treatment with @entity0 chorionic gonadotrophin and by electrical stimulation of the hypothalamus.

answer: @entity0


abstract: Precocious first ovulation, preceded by an endogenous preovulatory LH surge, could be predictably induced in immature female @entity1 by administering repeated injections of @entity0 chorionic gonadotrophin ( @entity2 ). Administration of a dose of 0.05-0.075 i.u. @entity2 , four times a day from day 28 to day 31 of age resulted in a highly constant ovulatory response: at 4.0 +/- 0.0 days after the start of treatment 7.7 +/- 0.3 (n = 15) ova were found. Use of a higher dose of @entity2 (0.1 i.u.) resulted in lower numbers of ova (5.6 +/- 0.4, n = 7; P less than 0.005) whereas use of a lower dose of @entity2 (0.025-0.038 i.u.) resulted in a less constant timing of the induced ovulation at 5.4 +/- 0.2 days after the start of treatment (n = 7; P less than 0.0005). In animals treated with the dose of 0.05-0.075 i.u. @entity2 , a positive correlation was found between body weight at the start of treatment and the number of ova released (r = 0.75, n = 25; P less than 0.001). Ovarian follicle dynamics were studied on the various days of @entity2 treatment (dose 0.05-0.075 i.u.) and compared with the follicle changes that take place after electrical stimulation of the hypothalamus, performed on day 28, a treatment known to result in first ovulation 4-5 days later. In both groups a decrease in the number of the smallest and the middle-sized antral follicles as compared with their respective controls was seen, whereas numbers of follicles in the largest, 'ovulatable' size classes gradually increased.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Precocious ovulation induced by @entity0 chorionic gonadotrophin in the immature female @entity1 : comparison of follicle growth induced by treatment with XXXX chorionic gonadotrophin and by electrical stimulation of the hypothalamus.

answer: @entity0


abstract: Precocious first ovulation, preceded by an endogenous preovulatory LH surge, could be predictably induced in immature female @entity1 by administering repeated injections of @entity0 chorionic gonadotrophin ( @entity2 ). Administration of a dose of 0.05-0.075 i.u. @entity2 , four times a day from day 28 to day 31 of age resulted in a highly constant ovulatory response: at 4.0 +/- 0.0 days after the start of treatment 7.7 +/- 0.3 (n = 15) ova were found. Use of a higher dose of @entity2 (0.1 i.u.) resulted in lower numbers of ova (5.6 +/- 0.4, n = 7; P less than 0.005) whereas use of a lower dose of @entity2 (0.025-0.038 i.u.) resulted in a less constant timing of the induced ovulation at 5.4 +/- 0.2 days after the start of treatment (n = 7; P less than 0.0005). In animals treated with the dose of 0.05-0.075 i.u. @entity2 , a positive correlation was found between body weight at the start of treatment and the number of ova released (r = 0.75, n = 25; P less than 0.001). Ovarian follicle dynamics were studied on the various days of @entity2 treatment (dose 0.05-0.075 i.u.) and compared with the follicle changes that take place after electrical stimulation of the hypothalamus, performed on day 28, a treatment known to result in first ovulation 4-5 days later. In both groups a decrease in the number of the smallest and the middle-sized antral follicles as compared with their respective controls was seen, whereas numbers of follicles in the largest, 'ovulatable' size classes gradually increased.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Precocious ovulation induced by @entity0 chorionic gonadotrophin in the immature female XXXX : comparison of follicle growth induced by treatment with @entity0 chorionic gonadotrophin and by electrical stimulation of the hypothalamus.

answer: @entity1


abstract: PURPOSE: To use a new methodological approach, based on luminance noise, to assess without bias the relative damage of blue-yellow and red-green pathways in @entity5 and @entity3 and to correlate obtained measurements with clinical markers of disease progression. METHODS: A psychophysical procedure modified from Cambridge color test was used to assess color discrimination in three different groups: @entity0 with primary @entity4 (n = 51 eyes), @entity0 with @entity5 (n = 95 eyes), and control subjects (n = 46 eyes). Viewing conditions were such that the function of the macula was being tested, using a discrimination task under noisy conditions. Confusion vectors, and parameters obtained from discrimination @entity6 were correlated with perimetric and clinical data taken from the same groups. RESULTS: The lengths of the major axis of chromatic discrimination @entity6 and all confusion vectors were significantly different between the groups. These measures followed a significant gradient of worsening performance from the control to @entity1 and @entity3 groups, which was steeper for the tritan axis. There was a significant global positive correlation between test parameters and cup-to-disc ratio and a significant negative correlation with the perimetric mean deviation index. @entity6 length in @entity0 with @entity5 correlated significantly with the duration of their @entity1 state. CONCLUSIONS: This psychophysical test can detect @entity2 in a significant subset of @entity0 with long-term @entity1 with preserved visual fields. Macular function is damaged earlier than previously believed, in both the blue-yellow and red-green pathways.

title: Simultaneous comparison of relative damage to chromatic pathways in XXXX and @entity3 : correlation with clinical measures.

answer: @entity5


abstract: PURPOSE: To use a new methodological approach, based on luminance noise, to assess without bias the relative damage of blue-yellow and red-green pathways in @entity5 and @entity3 and to correlate obtained measurements with clinical markers of disease progression. METHODS: A psychophysical procedure modified from Cambridge color test was used to assess color discrimination in three different groups: @entity0 with primary @entity4 (n = 51 eyes), @entity0 with @entity5 (n = 95 eyes), and control subjects (n = 46 eyes). Viewing conditions were such that the function of the macula was being tested, using a discrimination task under noisy conditions. Confusion vectors, and parameters obtained from discrimination @entity6 were correlated with perimetric and clinical data taken from the same groups. RESULTS: The lengths of the major axis of chromatic discrimination @entity6 and all confusion vectors were significantly different between the groups. These measures followed a significant gradient of worsening performance from the control to @entity1 and @entity3 groups, which was steeper for the tritan axis. There was a significant global positive correlation between test parameters and cup-to-disc ratio and a significant negative correlation with the perimetric mean deviation index. @entity6 length in @entity0 with @entity5 correlated significantly with the duration of their @entity1 state. CONCLUSIONS: This psychophysical test can detect @entity2 in a significant subset of @entity0 with long-term @entity1 with preserved visual fields. Macular function is damaged earlier than previously believed, in both the blue-yellow and red-green pathways.

title: Simultaneous comparison of relative damage to chromatic pathways in @entity5 and XXXX : correlation with clinical measures.

answer: @entity3


abstract: UNASSIGNED: Exact localization of the epileptogenic zone (EZ) is the first priority for ensuring @entity0 treatments and reducing side effects. The results of traditional visual methods for localizing the origin of @entity1 are far from satisfactory in some cases. Signal processing methods could extract substantial information that may complement visual inspection of EEG signals. In this study, EZ localization is changed into a driver identification problem, and a nonlinear interdependence measure, the weighted rank interdependence, is proposed and used as a driver indicator because it can detect coupling information, especially directionality, from EEG signals. A @entity2 ( @entity2 ) controller is then explored, using simulations, to establish its suitability for @entity1 control. The @entity1 control we propose rests on identifying the EZ using nonlinear interdependence measures of directed functional connectivity. Two directionally coupled neural mass models are employed for simulation investigation. Two parameters can adjust the sensitivity and completeness of the weighted rank interdependence for different applications, and their effect is discussed in the context of neural mass models. Simulation results demonstrate that use of the weighted rank interdependence for EZ identification can be applied to different EZ types, and the approach achieves an overall identification rate of 98.84  % for several EZ types. Simulations also indicate that @entity2 control can effectively regulate synchronization between neural masses.

title: Epileptogenic zone localization and XXXX control in coupled neural mass models.

answer: @entity1


abstract: UNASSIGNED: @entity3 ( @entity3 ) are a common complication during hemodialysis (HD) sessions. A number of pharmacologic agents have been evaluated to prevent and or diminish @entity3 ; however, none of them has an established role. To the best of our knowledge, this is the first study to evaluate the possible effect of @entity2 on @entity3 . In a double-blinded clinical trial, we compared the possible effect of @entity2 with a placebo in prevention and or diminishing episodes of @entity3 in HD @entity0 who had experienced frequent intradialytic muscle cramps. At first, placebo was given before each dialysis session for four weeks and then, after a two-week washout period, 300 mg of @entity2 was given before each dialysis session for four weeks to verify the effect of @entity2 on @entity3 . Overall, 15 @entity0 (seven @entity0 and eight @entity0 ; mean age, 52.02 years) with frequent intradialytic muscle cramps were enrolled in the study. The incidence of symptomatic muscle cramp decreased in the @entity2 group compared with the placebo group, with a significant difference between them (P = 0.001). The intensity of muscle cramps also decreased in the @entity2 group (P = 0.001). There was no significant association between @entity3 in male and female @entity0 (P = 0. 397), mean age of HD @entity0 (P = 0.226) and cause of @entity1 (P = 0.551). According to the results of our study, @entity2 prescription before each HD session significantly reduced the frequency and the intensity of muscle cramps during HD without any major side-effects.

title: The effect of XXXX on muscle cramps during hemodialysis: A double-blind clinical trial.

answer: @entity2


abstract: UNASSIGNED: Scedosporium apiospermum is the asexual form of a rare fungus Pseudallescheria boydii that is usually present in the soil, sewage and dirty water. In immunocompromised @entity0 , it is a rare @entity3 involving multiple organs. We present a case of renal allograft recipient who developed fever two weeks post renal transplant. He was initially found to have @entity4 . After five days, he became drowsy and developed right-sided @entity6 . Magnetic resonance imaging of the brain revealed multiple irregular masses with associated @entity1 consistent with fungal brain abscesses. Left parietal abscess was drained and he was started on @entity8 . His @entity2 was stopped. Drained pus revealed fungal hyphae on @entity7 stain and Scedosporium apiospermum on culture. Unfortunately, the @entity0 died after five days. Scedosporium @entity3 should be kept as a possibility in transplant recipients with disseminated @entity3 , especially with a @entity5 . Despite antifungal therapy and surgical drainage, mortality rates are high.

title: Scedosporium apiospermum causing XXXX in a renal allograft recipient.

answer: @entity5


abstract: BACKGROUND: @entity1 ( @entity1 ) is a potentially life-threatening @entity3 that occurs in previously well @entity0 during pregnancy or postpartum. The predictors of persistent left ventricular (LV) @entity2 (LVSD) in @entity1 are poorly understood and were the subject of this study. METHODS: @entity0 with @entity1 (n  = 71), who were admitted to Beijing Friendship Hospital from 2004 to 2011, were retrospectively analyzed. Data including electrocardiographic and echocardiographic measurements at diagnosis (baseline) and at the last follow-up visit were collected. Data on plasma @entity5 ( @entity5 ) and @entity4 ( @entity4 ) levels were also collected at baseline. A receiver operating characteristic curve was used to determine the cutoff values. Univariate and multivariate analyses were used to assess the significant predictive variables for persistent LVSD. RESULTS: Thirty-one @entity0 (44%) did not recover completely at the last follow-up visit (LV nonrecovery group), and 40 @entity0 (56%) had good LV recovery (LV recovery group). Baseline @entity5 level was positively correlated with LV end-diastolic diameter (r  = 0.559; P < 0.001), and inversely correlated with LV ejection fraction (LVEF) (r  =  -0.548; P < 0.001) and fractional shortening (r  =  -0.542; P < 0.001). There was no difference in @entity4 levels between the 2 groups. Receiver operating characteristic curves indicated the cutoff value in terms of predicting persistent LVSD was 34% for LVEF, 64 mm for LV end-diastolic diameter, 16% for fractional shortening, and 1860 pg/mL for @entity5 . Univariate and multivariate analyses confirmed that LVEF < 34% (95% CI, 1.38-7.30; P  = 0.007) and @entity5 > 1860 pg/mL (95% CI, 1.18-6.99; P  = 0.020) were independent prognostic factors in predicting persistent LVSD. CONCLUSIONS: LVEF and plasma @entity5 levels have good predictive value in long-term @entity2 .

title: Clinical Characteristics and Long-term Predictors of Persistent Left Ventricular Systolic Dysfunction in Peripartum XXXX .

answer: @entity1


abstract: BACKGROUND CONTEXT: A number of studies have reported favorable surgical results for metastatic @entity2 from various solid @entity2 . However, there are few data available on metastatic @entity5 (MSCC) from @entity1 despite its considerable frequency. PURPOSE: The study aims to present the functional outcomes, survival time, and complications after surgical treatment for MSCC from @entity4 ( @entity4 ). STUDY DESIGN/SETTING: This is a longitudinal observational study. @entity0 SAMPLE: The study includes 50 @entity0 who had @entity3 and underwent surgical treatment for MSCC from @entity4 . OUTCOME MEASURES: The Eastern Cooperative Oncology Group performance status (ECOG-PS), ambulatory status, overall survival, factors associated with survival time, and perioperative complications were analyzed. METHODS: The postoperative changes of ECOG-PS and ambulatory status were assessed. The factors affecting postoperative ambulatory status were evaluated using logistic regression analysis. Survival time was calculated using the Kaplan-Meier method. To identify the prognostic factors, log-rank test and Cox hazards regression model were used for univariate and multivariate analyses, respectively. Major complications within postoperative 30 days and mortality rate were recorded. RESULTS: The study cohort consisted of 27 males and 23 females with a mean age of 58.0  11.3 years at the time of surgery. An ECOG-PS improvement by at least one grade was observed in 33 of 50 cases (66.0%). Among 39 @entity0 who were not ambulatory before surgery, 23 @entity0 (59.0%) regained ambulatory ability after surgery. @entity0 who were preoperatively ambulant and those who underwent surgery within 72 hours from @entity3 had an increased chance of postoperative ambulation. The median for overall survival after surgery was 5.2 months. Five prognostic factors were identified on univariate analysis: time from @entity3 , responsiveness to preoperative chemotherapy, postoperative chemotherapy, postoperative ECOG-PS, and postoperative ambulatory status. Multivariate analysis revealed that time to @entity3 (risk ratio [RR]: 2.28, p=.023), postoperative chemotherapy (RR: 6.58, p<.001), and postoperative ECOG-PS (RR: 2.73, p=.040) were independent prognostic factors of survival time. Major complications developed in 34.0% of @entity0 (17 of 50), and the 30-day mortality rate was 10.0% (5 of 50). CONCLUSIONS: Functional improvements were observed through surgical treatment even with relatively high complication rates for MSCC from @entity4 . Earlier surgical treatment could act as an adjuvant therapy for prolonging survival by improving functional status.

title: Surgical results of metastatic XXXX (MSCC) from @entity4 ( @entity4 ): analysis of functional outcome, survival time, and complication.

answer: @entity5


abstract: BACKGROUND CONTEXT: A number of studies have reported favorable surgical results for metastatic @entity2 from various solid @entity2 . However, there are few data available on metastatic @entity5 (MSCC) from @entity1 despite its considerable frequency. PURPOSE: The study aims to present the functional outcomes, survival time, and complications after surgical treatment for MSCC from @entity4 ( @entity4 ). STUDY DESIGN/SETTING: This is a longitudinal observational study. @entity0 SAMPLE: The study includes 50 @entity0 who had @entity3 and underwent surgical treatment for MSCC from @entity4 . OUTCOME MEASURES: The Eastern Cooperative Oncology Group performance status (ECOG-PS), ambulatory status, overall survival, factors associated with survival time, and perioperative complications were analyzed. METHODS: The postoperative changes of ECOG-PS and ambulatory status were assessed. The factors affecting postoperative ambulatory status were evaluated using logistic regression analysis. Survival time was calculated using the Kaplan-Meier method. To identify the prognostic factors, log-rank test and Cox hazards regression model were used for univariate and multivariate analyses, respectively. Major complications within postoperative 30 days and mortality rate were recorded. RESULTS: The study cohort consisted of 27 males and 23 females with a mean age of 58.0  11.3 years at the time of surgery. An ECOG-PS improvement by at least one grade was observed in 33 of 50 cases (66.0%). Among 39 @entity0 who were not ambulatory before surgery, 23 @entity0 (59.0%) regained ambulatory ability after surgery. @entity0 who were preoperatively ambulant and those who underwent surgery within 72 hours from @entity3 had an increased chance of postoperative ambulation. The median for overall survival after surgery was 5.2 months. Five prognostic factors were identified on univariate analysis: time from @entity3 , responsiveness to preoperative chemotherapy, postoperative chemotherapy, postoperative ECOG-PS, and postoperative ambulatory status. Multivariate analysis revealed that time to @entity3 (risk ratio [RR]: 2.28, p=.023), postoperative chemotherapy (RR: 6.58, p<.001), and postoperative ECOG-PS (RR: 2.73, p=.040) were independent prognostic factors of survival time. Major complications developed in 34.0% of @entity0 (17 of 50), and the 30-day mortality rate was 10.0% (5 of 50). CONCLUSIONS: Functional improvements were observed through surgical treatment even with relatively high complication rates for MSCC from @entity4 . Earlier surgical treatment could act as an adjuvant therapy for prolonging survival by improving functional status.

title: Surgical results of metastatic @entity5 (MSCC) from XXXX ( @entity4 ): analysis of functional outcome, survival time, and complication.

answer: @entity4


abstract: BACKGROUND CONTEXT: A number of studies have reported favorable surgical results for metastatic @entity2 from various solid @entity2 . However, there are few data available on metastatic @entity5 (MSCC) from @entity1 despite its considerable frequency. PURPOSE: The study aims to present the functional outcomes, survival time, and complications after surgical treatment for MSCC from @entity4 ( @entity4 ). STUDY DESIGN/SETTING: This is a longitudinal observational study. @entity0 SAMPLE: The study includes 50 @entity0 who had @entity3 and underwent surgical treatment for MSCC from @entity4 . OUTCOME MEASURES: The Eastern Cooperative Oncology Group performance status (ECOG-PS), ambulatory status, overall survival, factors associated with survival time, and perioperative complications were analyzed. METHODS: The postoperative changes of ECOG-PS and ambulatory status were assessed. The factors affecting postoperative ambulatory status were evaluated using logistic regression analysis. Survival time was calculated using the Kaplan-Meier method. To identify the prognostic factors, log-rank test and Cox hazards regression model were used for univariate and multivariate analyses, respectively. Major complications within postoperative 30 days and mortality rate were recorded. RESULTS: The study cohort consisted of 27 males and 23 females with a mean age of 58.0  11.3 years at the time of surgery. An ECOG-PS improvement by at least one grade was observed in 33 of 50 cases (66.0%). Among 39 @entity0 who were not ambulatory before surgery, 23 @entity0 (59.0%) regained ambulatory ability after surgery. @entity0 who were preoperatively ambulant and those who underwent surgery within 72 hours from @entity3 had an increased chance of postoperative ambulation. The median for overall survival after surgery was 5.2 months. Five prognostic factors were identified on univariate analysis: time from @entity3 , responsiveness to preoperative chemotherapy, postoperative chemotherapy, postoperative ECOG-PS, and postoperative ambulatory status. Multivariate analysis revealed that time to @entity3 (risk ratio [RR]: 2.28, p=.023), postoperative chemotherapy (RR: 6.58, p<.001), and postoperative ECOG-PS (RR: 2.73, p=.040) were independent prognostic factors of survival time. Major complications developed in 34.0% of @entity0 (17 of 50), and the 30-day mortality rate was 10.0% (5 of 50). CONCLUSIONS: Functional improvements were observed through surgical treatment even with relatively high complication rates for MSCC from @entity4 . Earlier surgical treatment could act as an adjuvant therapy for prolonging survival by improving functional status.

title: Surgical results of metastatic @entity5 (MSCC) from @entity4 ( XXXX ): analysis of functional outcome, survival time, and complication.

answer: @entity4


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a potentially deadly @entity2 characterized by the absence of the enteric nervous system (ENS) in distal bowel. Although @entity4 has clear genetic causes, no @entity4 -associated mutation is 100% penetrant, suggesting gene-gene and gene-environment interactions determine @entity4 occurrence. To test the hypothesis that certain medicines might alter @entity4 risk we treated @entity6 with medications commonly used during early @entity0 pregnancy and discovered that @entity7 caused @entity4 -like absence of enteric neurons in distal bowel. Using fetal CF-1 @entity1 gut slice cultures, we found that @entity7 treated enteric neural crest-derived cells (ENCDC) had reduced migration, fewer lamellipodia and lower levels of active @entity8 / @entity11 . Additionally, inhibiting ROCK, a RHOA effector and known @entity8 antagonist, reversed @entity7 effects on migrating @entity1 ENCDC in culture. @entity7 also inhibited colonization of @entity9 +/- @entity1 bowel by ENCDC in vivo and dramatically reduced bowel colonization by @entity3 ENCDC in culture. Interestingly, @entity7 did not affect ENCDC migration until after at least three hours of exposure. Furthermore, @entity1 deficient in @entity13 ( @entity12 ) and @entity5 ( @entity10 ) had normal bowel colonization by ENCDC and normal ENCDC migration in vitro suggesting COX-independent effects. Consistent with selective and strain specific effects on ENCDC, @entity7 did not affect migration of gut mesenchymal cells, NIH3T3, or WT C57BL/6 ENCDC, and did not affect dorsal root ganglion cell precursor migration in @entity6 . Thus, @entity7 inhibits ENCDC migration in vitro and bowel colonization by ENCDC in vivo in @entity6 , @entity1 and @entity3 , but there are cell type and strain specific responses. These data raise concern that @entity7 may increase @entity4 risk in some genetically susceptible @entity0 .

title: XXXX slows migration and inhibits bowel colonization by enteric nervous system precursors in @entity6 , @entity3 and @entity1 .

answer: @entity7


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a potentially deadly @entity2 characterized by the absence of the enteric nervous system (ENS) in distal bowel. Although @entity4 has clear genetic causes, no @entity4 -associated mutation is 100% penetrant, suggesting gene-gene and gene-environment interactions determine @entity4 occurrence. To test the hypothesis that certain medicines might alter @entity4 risk we treated @entity6 with medications commonly used during early @entity0 pregnancy and discovered that @entity7 caused @entity4 -like absence of enteric neurons in distal bowel. Using fetal CF-1 @entity1 gut slice cultures, we found that @entity7 treated enteric neural crest-derived cells (ENCDC) had reduced migration, fewer lamellipodia and lower levels of active @entity8 / @entity11 . Additionally, inhibiting ROCK, a RHOA effector and known @entity8 antagonist, reversed @entity7 effects on migrating @entity1 ENCDC in culture. @entity7 also inhibited colonization of @entity9 +/- @entity1 bowel by ENCDC in vivo and dramatically reduced bowel colonization by @entity3 ENCDC in culture. Interestingly, @entity7 did not affect ENCDC migration until after at least three hours of exposure. Furthermore, @entity1 deficient in @entity13 ( @entity12 ) and @entity5 ( @entity10 ) had normal bowel colonization by ENCDC and normal ENCDC migration in vitro suggesting COX-independent effects. Consistent with selective and strain specific effects on ENCDC, @entity7 did not affect migration of gut mesenchymal cells, NIH3T3, or WT C57BL/6 ENCDC, and did not affect dorsal root ganglion cell precursor migration in @entity6 . Thus, @entity7 inhibits ENCDC migration in vitro and bowel colonization by ENCDC in vivo in @entity6 , @entity1 and @entity3 , but there are cell type and strain specific responses. These data raise concern that @entity7 may increase @entity4 risk in some genetically susceptible @entity0 .

title: @entity7 slows migration and inhibits bowel colonization by enteric nervous system precursors in XXXX , @entity3 and @entity1 .

answer: @entity6


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a potentially deadly @entity2 characterized by the absence of the enteric nervous system (ENS) in distal bowel. Although @entity4 has clear genetic causes, no @entity4 -associated mutation is 100% penetrant, suggesting gene-gene and gene-environment interactions determine @entity4 occurrence. To test the hypothesis that certain medicines might alter @entity4 risk we treated @entity6 with medications commonly used during early @entity0 pregnancy and discovered that @entity7 caused @entity4 -like absence of enteric neurons in distal bowel. Using fetal CF-1 @entity1 gut slice cultures, we found that @entity7 treated enteric neural crest-derived cells (ENCDC) had reduced migration, fewer lamellipodia and lower levels of active @entity8 / @entity11 . Additionally, inhibiting ROCK, a RHOA effector and known @entity8 antagonist, reversed @entity7 effects on migrating @entity1 ENCDC in culture. @entity7 also inhibited colonization of @entity9 +/- @entity1 bowel by ENCDC in vivo and dramatically reduced bowel colonization by @entity3 ENCDC in culture. Interestingly, @entity7 did not affect ENCDC migration until after at least three hours of exposure. Furthermore, @entity1 deficient in @entity13 ( @entity12 ) and @entity5 ( @entity10 ) had normal bowel colonization by ENCDC and normal ENCDC migration in vitro suggesting COX-independent effects. Consistent with selective and strain specific effects on ENCDC, @entity7 did not affect migration of gut mesenchymal cells, NIH3T3, or WT C57BL/6 ENCDC, and did not affect dorsal root ganglion cell precursor migration in @entity6 . Thus, @entity7 inhibits ENCDC migration in vitro and bowel colonization by ENCDC in vivo in @entity6 , @entity1 and @entity3 , but there are cell type and strain specific responses. These data raise concern that @entity7 may increase @entity4 risk in some genetically susceptible @entity0 .

title: @entity7 slows migration and inhibits bowel colonization by enteric nervous system precursors in @entity6 , XXXX and @entity1 .

answer: @entity3


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a potentially deadly @entity2 characterized by the absence of the enteric nervous system (ENS) in distal bowel. Although @entity4 has clear genetic causes, no @entity4 -associated mutation is 100% penetrant, suggesting gene-gene and gene-environment interactions determine @entity4 occurrence. To test the hypothesis that certain medicines might alter @entity4 risk we treated @entity6 with medications commonly used during early @entity0 pregnancy and discovered that @entity7 caused @entity4 -like absence of enteric neurons in distal bowel. Using fetal CF-1 @entity1 gut slice cultures, we found that @entity7 treated enteric neural crest-derived cells (ENCDC) had reduced migration, fewer lamellipodia and lower levels of active @entity8 / @entity11 . Additionally, inhibiting ROCK, a RHOA effector and known @entity8 antagonist, reversed @entity7 effects on migrating @entity1 ENCDC in culture. @entity7 also inhibited colonization of @entity9 +/- @entity1 bowel by ENCDC in vivo and dramatically reduced bowel colonization by @entity3 ENCDC in culture. Interestingly, @entity7 did not affect ENCDC migration until after at least three hours of exposure. Furthermore, @entity1 deficient in @entity13 ( @entity12 ) and @entity5 ( @entity10 ) had normal bowel colonization by ENCDC and normal ENCDC migration in vitro suggesting COX-independent effects. Consistent with selective and strain specific effects on ENCDC, @entity7 did not affect migration of gut mesenchymal cells, NIH3T3, or WT C57BL/6 ENCDC, and did not affect dorsal root ganglion cell precursor migration in @entity6 . Thus, @entity7 inhibits ENCDC migration in vitro and bowel colonization by ENCDC in vivo in @entity6 , @entity1 and @entity3 , but there are cell type and strain specific responses. These data raise concern that @entity7 may increase @entity4 risk in some genetically susceptible @entity0 .

title: @entity7 slows migration and inhibits bowel colonization by enteric nervous system precursors in @entity6 , @entity3 and XXXX .

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) occurs frequently in @entity1 , but most previous studies examining the diagnosis of @entity2 have used data from secondary care hospitals. HYPOTHESIS/OBJECTIVES: The aim of this study was to investigate the clinical utility of diagnostic laboratory tests in @entity1 with @entity2 in a primary care hospital. ANIMALS: Sixty-four @entity1 with clinical signs suggestive of @entity2 diagnosed with @entity0 ( @entity0 ) or @entity2 . METHODS: Medical records were retrospectively reviewed, including diagnostic laboratory tests considered potentially useful in the diagnosis of @entity2 . The diagnostic accuracy of amylase and FUJI DRI-CHEM lipase (FDC lip) were investigated using receiver operating characteristics (ROC). In addition, we verified whether diagnostic laboratory tests were useful for evaluating duration of hospitalization and as biomarkers for monitoring recovery. RESULTS: Activities of amylase and FDC lip were significantly higher in the @entity2 group than in the @entity0 group (P = .001, P < .001, respectively). The sensitivity of FDP lip activity for diagnosing @entity2 was 100% (95% confidence interval [CI], 87.7-100%); the specificity was 89.5% (95% CI, 66.9-98.7%). Area under the ROC curve for FDC lip activity was 0.98 (95% CI, 0.93-1). High @entity3 aminotransferase (ALT) activity was associated with extended duration of hospitalization (P = .04). A significant difference in @entity4 ( @entity4 ) concentration before and 5 days after treatment was found (P = .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Measurement of FDC lip activity appears useful for diagnosing @entity2 . High ALT activity might be associated with prolonged duration of hospitalization, and @entity4 might be useful as a biomarker for monitoring recovery from @entity2 .

title: Clinical Utility of Diagnostic Laboratory Tests in XXXX with Acute Pancreatitis: A Retrospective Investigation in a Primary Care Hospital.

answer: @entity1