abstract: Background @entity3 is a common surgical disease. Tension-free hernioplasty is currently commonly used for its treatment, with multiple advantages such as simple surgical method, low recurrence rate, and ability to be performed in primary care hospitals, but the risk of incision @entity4 still exists. Mild @entity4 can be cured by local washing, dressing, and systemic antibiotics. If the @entity4 is severe, the wound may not heal after removing the patch, and secondary suturing is needed. Material and Methods A total of 60 @entity0 with @entity1 after tension-free repair of @entity3 were randomly divided into control (n=30) and treatment (n=30) groups. @entity0 in the treatment group received Mesalt combined with Mepilex for dressing while the @entity0 in the control group received conventional gauze for dressing. @entity2 degree, wound healing time, and dressing times were observed. Results The clinical therapeutic effect in the treatment group was significantly better than in the control group. The treatment group exhibited significantly less @entity2 when @entity0 receive dressing, shorter wounds healing time (15  3.5 vs. 30  5.0), and less dressing frequency (10  2.1 vs. 20  2.4). Conclusions Mesalt combined with Mepilex can effectively improve @entity1 after @entity3 treatment, obviously reducing @entity2 , shorting wound healing time, and decreasing dressing frequency. It can be widely used in clinical practice.

title: Clinical curative effect of mesalt combined with mepilex dressing in XXXX of @entity3 .

answer: @entity1


abstract: PURPOSE: Aim of this study was to record and compare the functional and activity level as well as the manifestations of @entity2 after isolated @entity1 between @entity0 with conservative treatment and ACL reconstruction with hamstrings tendon graft. METHODS: Thirty-two @entity0 diagnosed with @entity1 were recorded. Clinical examination included the Tegner and Lysholm activity scale, the International Knee Documentation Committee Subjective Form and KT-1000 arthrometer. Narrowing of the medial and lateral joint spaces was assessed using the IKDC knee examination score. RESULTS: Median follow-up was 10.3  years (range 10-11). Fifteen @entity0 were conservatively treated (median age 33  years, range 25-39). Seventeen @entity0 were operated (median age 31  years, range 20-36). There was significant difference between the mean values of IKDC scores in favour of the ACL-reconstruction group of @entity0 , 86.8 (SD 6.5) versus 77.5 (SD 13.8), respectively (p  =  0.04). The mean value of anteroposterior tibial translation was 1.5  mm (SD 0.2) for ACL-reconstruction group of @entity0 , while the corresponding mean value for ACL-conservative group was 4.5  mm (SD 0.5), p  =  0.03. Four @entity0 in ACL-reconstruction group had radiological findings of grade C or D according to IKDC form. In ACL-conservative group, five @entity0 presented similar signs (n.s.). CONCLUSIONS: ACL reconstruction using hamstrings autograft resulted in better functional outcome and laxity measurements than ACL-conservative management. However, the incidence of radiological @entity2 was similar between the two groups and independent on the pre-operative grade of laxity and functional status of the @entity0 . Equally, bone bruises were not found as a risk factor for the development of @entity2 after @entity1 . LEVEL OF EVIDENCE: Prospective randomized study, Level II.

title: No difference in XXXX after surgical and non-surgical treatment of ACL-injured knees after 10  years.

answer: @entity2


abstract: INTRODUCTION: Prosthetic reinforcement is a critical component of @entity2 repair. For massive defects, mesh overlap is often limited by the dimensions of commercially available implants. In scenarios where larger mesh prosthetics are required for adequate reinforcement, it may be necessary to join several pieces of mesh together using non-absorbable suture. Here, we report our outcomes for abdominal wall reconstructions in which "quilted" mesh was utilized for fascial reinforcement. METHODS: @entity0 undergoing open incisional @entity3 and transversus abdominis muscle release, with use of quilted synthetic mesh placed in the retromuscular position, were reviewed. Main outcome measures included @entity0 , @entity2 , and operative characteristics and post-operative outcomes, including surgical site occurrence (SSO), @entity1 ( @entity1 ), and recurrence. RESULTS: Thirty-two @entity0 (mean age 55.7      9.3, BMI 38.3      5.8  kg/m(2)) underwent open @entity4 repair with "quilted" mesh placed in the retromuscular position. The mean defect area was 760.1      311.0 cm(2) with a mean width of 24.7      6.4  cm. Quilted meshes consisted of two-piece (69  %), three-piece (19  %) and four-piece (12  %) configurations. Wound morbidity consisted of eight (25  %) SSOs, including four (13  %) SSIs, all of which resolved without mesh excision. With mean follow-up of 9.0      13.6  months, there were two (6.3  %) lateral recurrences, both unassociated with mesh-to-mesh suture line failure. CONCLUSIONS: Massive @entity4 that require giant mesh prosthetics, currently not commercially available, may be successfully repaired using multiple mesh pieces sewn together in a quilt-like fashion. Such retromuscular repairs are durable, without added morbidity due to the mesh-to-mesh suture line. However, additional operative time is required for quilting the mesh together, prompting strong calls for manufacturing of larger mesh prosthetics.

title: Repair of massive XXXX with "quilted" mesh.

answer: @entity4


abstract: BACKGROUND: @entity2 ( @entity2 ) is the eighth most common @entity1 as estimated from worldwide data. The incidence of @entity2 was reported as 8.5 per 100,000 population. This study was aimed to determine the treatment outcomes for @entity2 @entity0 treated in the Oncology Unit of University Malaya Medical Centre (UMMC). MATERIALS AND METHODS: All newly diagnosed @entity0 with @entity4 of @entity2 ( @entity3 ) referred for treatment to the Oncology Unit at UMMC from 2003-2010 were retrospectively analyzed. Treatment outcomes were 5-year overall survival (OS), cause specific survival (CSS), loco-regional control (LRC) and radiotherapy (RT) related side effects. Kaplan-Meier and log rank analyses were used to determine survival outcomes, stratified according to American Joint Committee on Cancer (AJCC) stage. RESULTS: A total of 130 cases were analysed. Most cases (81.5%) were at late stage (AJCC III-IVB) at presentation. The 5-year OS for the whole study population was 34.4% with a median follow up of 24 months. The 5-year OS according to AJCC stage was 100%, 48.2%, 41.4% and 22.0% for stage I, II, III and IVA-B, respectively. The 5-year overall CSS and LCR were 45.4% and 55.4%, respectively. Late effects of RT were documented in 41.4% of @entity0 . The most common late effect was @entity5 . CONCLUSIONS: The treatment outcome of @entity3 at our centre is lagging behind those of developed nations. Efforts to increase the number of @entity0 presenting in earlier stages, increase in the use of combined modality treatment, especially concurrent chemoradiotherapy and implementation of intensity modulated radiotherapy, may lead to better outcomes for our @entity2 @entity0 .

title: Treatment outcome for XXXX in a developing country: university malaya medical centre, malaysia from 2003-2010.

answer: @entity3


abstract: OBJECTIVES: @entity5 ( @entity5 ) is the most common complication seen following laparoscopic surgery. Our study sought to evaluate the efficacy of the newer drug @entity7 with that of @entity6 , in combination with @entity4 , for @entity5 in @entity0 undergoing laparoscopic hysterectomies.   . METHODS: A total of 90 @entity0 , aged between 30-50 years old, posted for elective laparoscopic hysterectomies under general anesthesia belonging to the American Society of Anesthesiologist (ASA) physical status I and II were included in the study. @entity0 were randomly divided into one of two groups (n=45). Before induction, @entity0 in the first group (group I) received 0.075mg @entity7 with 8mg @entity4 and @entity0 in the second group (group II) received 4mg @entity6 with 8mg @entity4 . Postoperatively, any incidences of @entity3 , requirement of rescue antiemetic, and side effects were recorded. @entity0 's hemodynamics were also monitored. Statistical analysis was done using Student's t-test, chi-square test, and Fisher's exact test.   . RESULTS: Preoperative, intraoperative, and postoperative heart rate, mean arterial pressure, peripheral capillary @entity1 saturation were statistically not significant (p>0.050) in either group. In group II, eight @entity0 had @entity2 in the first two hours and three @entity0 had @entity2 in the two to six-hour postoperative period. In group I, three @entity0 experienced @entity2 in the first six hours period. Eight @entity0 in group II had vomited in the first two-hour period compared to one @entity0 in group I (p=0.013). The requirement of rescue antiemetic was greater in group II than group I (20% vs. 4%). No side effects of antiemetic use were observed in either group.   . CONCLUSION: The combination of @entity7 with @entity4 is more effective in treating early, delayed, and long term @entity5 compared to @entity6 with @entity4 in @entity0 undergoing elective laparoscopic hysterectomies under general anesthesia.

title: @entity5 and Vomiting: @entity7 with XXXX vs. @entity6 with @entity4 in Laparoscopic Hysterectomies.

answer: @entity4


abstract: OBJECTIVES: @entity5 ( @entity5 ) is the most common complication seen following laparoscopic surgery. Our study sought to evaluate the efficacy of the newer drug @entity7 with that of @entity6 , in combination with @entity4 , for @entity5 in @entity0 undergoing laparoscopic hysterectomies.   . METHODS: A total of 90 @entity0 , aged between 30-50 years old, posted for elective laparoscopic hysterectomies under general anesthesia belonging to the American Society of Anesthesiologist (ASA) physical status I and II were included in the study. @entity0 were randomly divided into one of two groups (n=45). Before induction, @entity0 in the first group (group I) received 0.075mg @entity7 with 8mg @entity4 and @entity0 in the second group (group II) received 4mg @entity6 with 8mg @entity4 . Postoperatively, any incidences of @entity3 , requirement of rescue antiemetic, and side effects were recorded. @entity0 's hemodynamics were also monitored. Statistical analysis was done using Student's t-test, chi-square test, and Fisher's exact test.   . RESULTS: Preoperative, intraoperative, and postoperative heart rate, mean arterial pressure, peripheral capillary @entity1 saturation were statistically not significant (p>0.050) in either group. In group II, eight @entity0 had @entity2 in the first two hours and three @entity0 had @entity2 in the two to six-hour postoperative period. In group I, three @entity0 experienced @entity2 in the first six hours period. Eight @entity0 in group II had vomited in the first two-hour period compared to one @entity0 in group I (p=0.013). The requirement of rescue antiemetic was greater in group II than group I (20% vs. 4%). No side effects of antiemetic use were observed in either group.   . CONCLUSION: The combination of @entity7 with @entity4 is more effective in treating early, delayed, and long term @entity5 compared to @entity6 with @entity4 in @entity0 undergoing elective laparoscopic hysterectomies under general anesthesia.

title: @entity5 and Vomiting: @entity7 with @entity4 vs. @entity6 with XXXX in Laparoscopic Hysterectomies.

answer: @entity4


abstract: OBJECTIVES: @entity5 ( @entity5 ) is the most common complication seen following laparoscopic surgery. Our study sought to evaluate the efficacy of the newer drug @entity7 with that of @entity6 , in combination with @entity4 , for @entity5 in @entity0 undergoing laparoscopic hysterectomies.   . METHODS: A total of 90 @entity0 , aged between 30-50 years old, posted for elective laparoscopic hysterectomies under general anesthesia belonging to the American Society of Anesthesiologist (ASA) physical status I and II were included in the study. @entity0 were randomly divided into one of two groups (n=45). Before induction, @entity0 in the first group (group I) received 0.075mg @entity7 with 8mg @entity4 and @entity0 in the second group (group II) received 4mg @entity6 with 8mg @entity4 . Postoperatively, any incidences of @entity3 , requirement of rescue antiemetic, and side effects were recorded. @entity0 's hemodynamics were also monitored. Statistical analysis was done using Student's t-test, chi-square test, and Fisher's exact test.   . RESULTS: Preoperative, intraoperative, and postoperative heart rate, mean arterial pressure, peripheral capillary @entity1 saturation were statistically not significant (p>0.050) in either group. In group II, eight @entity0 had @entity2 in the first two hours and three @entity0 had @entity2 in the two to six-hour postoperative period. In group I, three @entity0 experienced @entity2 in the first six hours period. Eight @entity0 in group II had vomited in the first two-hour period compared to one @entity0 in group I (p=0.013). The requirement of rescue antiemetic was greater in group II than group I (20% vs. 4%). No side effects of antiemetic use were observed in either group.   . CONCLUSION: The combination of @entity7 with @entity4 is more effective in treating early, delayed, and long term @entity5 compared to @entity6 with @entity4 in @entity0 undergoing elective laparoscopic hysterectomies under general anesthesia.

title: XXXX and Vomiting: @entity7 with @entity4 vs. @entity6 with @entity4 in Laparoscopic Hysterectomies.

answer: @entity5


abstract: OBJECTIVES: @entity5 ( @entity5 ) is the most common complication seen following laparoscopic surgery. Our study sought to evaluate the efficacy of the newer drug @entity7 with that of @entity6 , in combination with @entity4 , for @entity5 in @entity0 undergoing laparoscopic hysterectomies.   . METHODS: A total of 90 @entity0 , aged between 30-50 years old, posted for elective laparoscopic hysterectomies under general anesthesia belonging to the American Society of Anesthesiologist (ASA) physical status I and II were included in the study. @entity0 were randomly divided into one of two groups (n=45). Before induction, @entity0 in the first group (group I) received 0.075mg @entity7 with 8mg @entity4 and @entity0 in the second group (group II) received 4mg @entity6 with 8mg @entity4 . Postoperatively, any incidences of @entity3 , requirement of rescue antiemetic, and side effects were recorded. @entity0 's hemodynamics were also monitored. Statistical analysis was done using Student's t-test, chi-square test, and Fisher's exact test.   . RESULTS: Preoperative, intraoperative, and postoperative heart rate, mean arterial pressure, peripheral capillary @entity1 saturation were statistically not significant (p>0.050) in either group. In group II, eight @entity0 had @entity2 in the first two hours and three @entity0 had @entity2 in the two to six-hour postoperative period. In group I, three @entity0 experienced @entity2 in the first six hours period. Eight @entity0 in group II had vomited in the first two-hour period compared to one @entity0 in group I (p=0.013). The requirement of rescue antiemetic was greater in group II than group I (20% vs. 4%). No side effects of antiemetic use were observed in either group.   . CONCLUSION: The combination of @entity7 with @entity4 is more effective in treating early, delayed, and long term @entity5 compared to @entity6 with @entity4 in @entity0 undergoing elective laparoscopic hysterectomies under general anesthesia.

title: @entity5 and Vomiting: XXXX with @entity4 vs. @entity6 with @entity4 in Laparoscopic Hysterectomies.

answer: @entity7


abstract: OBJECTIVES: @entity5 ( @entity5 ) is the most common complication seen following laparoscopic surgery. Our study sought to evaluate the efficacy of the newer drug @entity7 with that of @entity6 , in combination with @entity4 , for @entity5 in @entity0 undergoing laparoscopic hysterectomies.   . METHODS: A total of 90 @entity0 , aged between 30-50 years old, posted for elective laparoscopic hysterectomies under general anesthesia belonging to the American Society of Anesthesiologist (ASA) physical status I and II were included in the study. @entity0 were randomly divided into one of two groups (n=45). Before induction, @entity0 in the first group (group I) received 0.075mg @entity7 with 8mg @entity4 and @entity0 in the second group (group II) received 4mg @entity6 with 8mg @entity4 . Postoperatively, any incidences of @entity3 , requirement of rescue antiemetic, and side effects were recorded. @entity0 's hemodynamics were also monitored. Statistical analysis was done using Student's t-test, chi-square test, and Fisher's exact test.   . RESULTS: Preoperative, intraoperative, and postoperative heart rate, mean arterial pressure, peripheral capillary @entity1 saturation were statistically not significant (p>0.050) in either group. In group II, eight @entity0 had @entity2 in the first two hours and three @entity0 had @entity2 in the two to six-hour postoperative period. In group I, three @entity0 experienced @entity2 in the first six hours period. Eight @entity0 in group II had vomited in the first two-hour period compared to one @entity0 in group I (p=0.013). The requirement of rescue antiemetic was greater in group II than group I (20% vs. 4%). No side effects of antiemetic use were observed in either group.   . CONCLUSION: The combination of @entity7 with @entity4 is more effective in treating early, delayed, and long term @entity5 compared to @entity6 with @entity4 in @entity0 undergoing elective laparoscopic hysterectomies under general anesthesia.

title: @entity5 and Vomiting: @entity7 with @entity4 vs. XXXX with @entity4 in Laparoscopic Hysterectomies.

answer: @entity6


abstract: INTRODUCTION: Heart rate (HR) is a strong prognostic indicator in @entity0 with @entity1 ( @entity1 ). However, there is only limited evidence on HR and the use of b-blockers in @entity0 with @entity1 in contemporary clinical practice. METHODS: CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable @entity1 , defined as prior @entity3 or revascularization procedure, evidence of @entity8 >50%, or @entity4 associated with proven @entity5 . A total of 33,283 @entity0 from 45 countries were enrolled between November 2009 and July 2010; of these, 559 @entity0 were enrolled in Greece (age 62.3    10.6 years, 84.44% @entity0 ). RESULTS: HR measured by pulse was 68.3    10.2 bpm and by electrocardiogram 67.6    10.9, with an excellent correlation (r=0.91, p<0.001). Overall, 42.8% had HR70 bpm. B-blockers were prescribed in 74.2% of @entity0 . Resting HR by pulse on b-blocker was 67.8 bpm and without b-blocker 69.6 bpm (p=0.069). HR70 bpm was independently associated with a lack of physical activity, higher systolic blood pressure, and a higher prevalence of @entity2 or @entity6 and @entity7 . CONCLUSION: Despite the use of HR lowering agents, the percentage of @entity0 with HR70 bpm was high. It is likely that we can further improve HR control in Greek @entity0 with stable @entity1 by both increasing the prescription of b-blockers and up-titrating their dose, as well as by using and up-titrating other available HR lowering agents.

title: Heart rate and B-blockade in stable XXXX in Greece.

answer: @entity1


abstract: INTRODUCTION: Only a few studies have investigated the structural and functional characteristics of carotid arteries bilaterally. Furthermore, there is controversy as to whether @entity2 in paired vascular beds is a local or systemic phenomenon. We aimed to examine, in @entity0 with @entity6 , whether intra-subject left and right carotid arteries have similar inflammatory status, as determined non-invasively by microwave radiometry (MWR). METHODS: Consecutive @entity0 (n=200) with significant @entity6 were evaluated via an ultrasound echo-colour Doppler (US-ECD) study of both carotid arteries and temperature measurements with MWR. During thermography, thermal heterogeneity (T) was defined as the maximum temperature along the carotid artery minus the minimum temperature. RESULTS: Mean T was similar between the left and right carotid arteries (0.78    0.48 vs. 0.84    0.52  C, p=0.12). Mean right @entity5 ( @entity5 ) was greater compared to mean left @entity5 (2.16    1.20 vs. 1.93    0.94 mm, p<0.01). In all carotids, there was a correlation between left and right carotid plaque T (R=0.38, p<0.001) and between left and right @entity5 (R=0.48, p<0.001). Independent predictors for the presence of bilateral carotid plaques were found to be the extent of @entity6 , high T, and therapy with @entity8 receptor blockers; predictors for the presence of high T bilaterally were bilateral carotid plaques, male sex, @entity1 , and @entity4 . CONCLUSIONS: There is bilateral inflammatory activation in the carotid @entity7 of @entity0 with @entity6 . At this stage of @entity3 , arterial @entity4 and @entity1 are more strongly correlated with bilateral functional abnormalities in carotid plaques than with structural changes.

title: Bilateral symmetry of local inflammatory activation in XXXX carotid atherosclerotic plaques.

answer: @entity0


abstract: @entity6 can be reduced by cryoanalgesia of intercostal nerves. The technique involves focal freezing of peripheral nerves to interrupt @entity6 pathways, producing immediate functional changes that recover as the nerves regenerate. To assess the time-course of functional changes that follow nerve @entity3 were induced in @entity1 with a cryosurgical unit. The contralateral nerves were used as sham-operated controls. Following @entity4 , behavioral and electrophysiologic tests were repeated to 90 days. The acute effect of @entity4 was a decrease in behavioral measures of hind limb function (P less than 0.05), an increase in electrical threshold to elicit hind limb contraction (P less than 0.005), and an absence of stimulus-evoked compound action potential (P less than 0.005). Morphologic changes included substantial endoneurial @entity0 associated with @entity8 . Remyelination occurred subsequently during the following 35 days. Although all physiologic measures returned toward normal, nerve conduction velocities were still much slower in the experimental group. In a second study, the long-term effects of cryogenic injury were compared with @entity5 with 10% @entity9 @entity7 , both of which produced a conduction velocity deficit that persisted at least 90 days after the @entity5 . These behavioral and electrophysiologic results complement previous reports of morphologic @entity2 including incomplete recovery of nerve fiber diameter and increased thickness of the @entity10 .

title: Behavioral and electrophysiological recovery following cryogenic XXXX .

answer: @entity4


abstract: Respiratory complications are the most frequent adverse events in @entity0 undergoing esophagectomy for @entity1 , and their occurrence may negatively affect postoperative recovery and outcomes. We queried the American College of Surgeons National Surgical Quality Improvement Program dataset to study the rate and influence of @entity2 , unplanned intubation, and ventilator dependency >48 hours on the early outcomes after esophagectomy and risk factors for their development. We included adult @entity0 with an esophageal or @entity4 diagnosis who were treated with esophagectomy between 2005 and 2012 and grouped them into 2 categories with respect to development of @entity7 . Early surgical outcomes (including 30-day mortality, overall morbidity, return to operating room, and length of hospital stay) were compared. Risk factors associated with @entity7 after esophagectomy were assessed using modified Poisson regression. A total of 2945 @entity0 were identified and @entity7 were observed in 687 (23.3%) of them. We observed a significant @entity7 rates after esophagectomy throughout the studied years. @entity0 who developed @entity7 were older and had more comorbidities and longer operative time. These @entity0 also had statistically significantly higher rates of 30-day mortality and overall morbidity and were more likely to return to the operating room and to stay in the hospital longer. On multivariable analysis, numerous factors, including advanced age, smoking, @entity3 use, @entity6 , history of @entity5 , and prolonged operative time, were found to be risk factors for developing @entity7 . As the development of @entity7 leads to worse early surgical outcomes after esophagectomy, efforts should be made to prevent their occurrence by identifying @entity0 with significant risk factors.

title: Incidence and Risk Factors for Respiratory Complications in XXXX Undergoing Esophagectomy for Malignancy: A NSQIP Analysis.

answer: @entity0


abstract: OBJECTIVE: @entity1 @entity0 are at high risk for life-threatening @entity3 ( @entity3 ) events. We examined the relationship between prophylactic inferior vena cava (IVC) filter use, mortality, and @entity3 . SUMMARY BACKGROUND DATA: The prevalence of prophylactic placement of IVC filters has increased among @entity1 @entity0 . However, there exists little data on the overall efficacy of prophylactic IVC filters with regard to outcomes. METHODS: @entity1 quality collaborative data from 2010 to 2014 were analyzed. @entity0 were excluded with no signs of life, Injury Severity Score <9, hospitalization <3 days, or who received IVC filter after occurrence of @entity3 event. Risk-adjusted rates of IVC filter placement were calculated and hospitals placed into quartiles of IVC filter use. Mortality rates by quartile were compared. We also determined the association of @entity2 ( @entity2 ) with the presence of an IVC filter, accounting for type and timing of initiation of pharmacological @entity3 prophylaxis. RESULTS: A prophylactic IVC filter was placed in 803 (2%) of 39,456 @entity0 . Hospitals exhibited significant variability (0.6% to 9.6%) in adjusted rates of IVC filter utilization. Rates of IVC placement within quartiles were 0.7%, 1.3%, 2.1%, and 4.6%, respectively. IVC filter use quartiles showed no variation in mortality. Adjusting for pharmacological @entity3 prophylaxis and @entity0 factors, prophylactic IVC filter placement was associated with an increased incidence of @entity2 (OR=1.83; 95% CI, 1.15-2.93, P-value=0.01). CONCLUSIONS: High rates of prophylactic IVC filter placement have no effect on reducing @entity1 @entity0 mortality and are associated with an increase in @entity2 events.

title: Prophylactic Inferior Vena Cava Filter Placement Does Not Result in a Survival Benefit for XXXX @entity0 .

answer: @entity1


abstract: OBJECTIVE: @entity1 @entity0 are at high risk for life-threatening @entity3 ( @entity3 ) events. We examined the relationship between prophylactic inferior vena cava (IVC) filter use, mortality, and @entity3 . SUMMARY BACKGROUND DATA: The prevalence of prophylactic placement of IVC filters has increased among @entity1 @entity0 . However, there exists little data on the overall efficacy of prophylactic IVC filters with regard to outcomes. METHODS: @entity1 quality collaborative data from 2010 to 2014 were analyzed. @entity0 were excluded with no signs of life, Injury Severity Score <9, hospitalization <3 days, or who received IVC filter after occurrence of @entity3 event. Risk-adjusted rates of IVC filter placement were calculated and hospitals placed into quartiles of IVC filter use. Mortality rates by quartile were compared. We also determined the association of @entity2 ( @entity2 ) with the presence of an IVC filter, accounting for type and timing of initiation of pharmacological @entity3 prophylaxis. RESULTS: A prophylactic IVC filter was placed in 803 (2%) of 39,456 @entity0 . Hospitals exhibited significant variability (0.6% to 9.6%) in adjusted rates of IVC filter utilization. Rates of IVC placement within quartiles were 0.7%, 1.3%, 2.1%, and 4.6%, respectively. IVC filter use quartiles showed no variation in mortality. Adjusting for pharmacological @entity3 prophylaxis and @entity0 factors, prophylactic IVC filter placement was associated with an increased incidence of @entity2 (OR=1.83; 95% CI, 1.15-2.93, P-value=0.01). CONCLUSIONS: High rates of prophylactic IVC filter placement have no effect on reducing @entity1 @entity0 mortality and are associated with an increase in @entity2 events.

title: Prophylactic Inferior Vena Cava Filter Placement Does Not Result in a Survival Benefit for @entity1 XXXX .

answer: @entity0


abstract: OBJECTIVE: Recently, Next Generation Sequencing (NGS) has begun to supplant other technologies for gene mutation testing that is now required for targeted therapies. However, transfer of NGS technology to clinical daily practice requires validation. METHODS: We validated the Ion Torrent AmpliSeq Colon and @entity0 panel interrogating 1850 hotspots in 22 genes using the Ion Torrent Personal Genome Machine. First, we used commercial reference standards that carry mutations at defined @entity6 ( @entity6 ). Then, 51 @entity1 ( @entity1 ) and 39 @entity5 ( @entity5 ) were retrospectively analyzed. RESULTS: Sensitivity and accuracy for detecting variants at an @entity6 >4% was 100% for commercial reference standards. Among the 90 cases, 89 (98.9%) were successfully sequenced. Among the 86 samples for which NGS and the reference test were both informative, 83 showed concordant results between NGS and the reference test; i.e. @entity4 and @entity3 for @entity1 and @entity2 for @entity5 , with the 3 discordant cases each characterized by an @entity6 <10%. CONCLUSIONS: Overall, the AmpliSeq @entity0 panel was specific and sensitive for mutation analysis of gene panels and can be incorporated into clinical daily practice.

title: Clinical Validation of Targeted Next Generation Sequencing for XXXX .

answer: @entity0


abstract: BACKGROUND: A bias in perceived risk for health outcomes, including @entity1 , exists. PURPOSE: We compared perceived risk and biases in perceived risk for @entity1 to @entity1 preventive behavior. METHODS: @entity0 over age 55 (n   =   2874) completed a survey five times over 5  years, and data was pulled from the medical record. Perceived risk was measured by asking @entity0 to rate their risk of @entity1 compared to similar @entity0 . Actual risk was measured using FRAX score. Bias was measured using an interaction between perceived and actual risk. RESULTS: Higher perceived risk was related to lower quality of life and self-reported health, more medication and @entity2 use, increased bone density scan use, and less walking. Bias was only associated with less medication use. Neither perceived risk nor bias predicted medication adherence. CONCLUSIONS: Perceived risk, but not bias, may predict different @entity1 prevention behaviors. Clinicians may need to base interventions on risk perceptions.

title: The Relationship of Perceived Risk and Biases in Perceived Risk to Fracture Prevention Behavior in Older XXXX .

answer: @entity0


abstract: UNASSIGNED: Langerhans cell sarcoma is a very rare and aggressive @entity2 of Langerhans cell lineage, for which aberrant expression of T-cell-related antigens has not yet been reported in a primary @entity9 . The authors describe the first known case of a primary @entity17 with lineage infidelity and use comparative genomic hybridization to investigate the genetic composition of the @entity2 and detect DNA copy number alterations throughout its entire genome. The case involves a 62-year-old @entity0 who presented with an irregular nodule on the forehead surrounded by smaller lesions in its vicinity. The clinical impression was @entity5 with satellitosis. The biopsy specimen showed an epidermotropic @entity2 with moderate-to-marked cellular pleomorphism and significantly increased mitotic rate but no @entity3 . The immunoprofile of the lesion was remarkable, as next to common Langerhans cell markers: @entity15 , @entity13 , @entity11 , and @entity6 ; it also exhibited an aberrant T-cell phenotype with the expression of @entity12 , CD3, and @entity16 . In addition, fascin and @entity14 were also expressed, further exaggerating potential diagnostic pitfalls. Langerhans cell lineage was confirmed by the demonstration of characteristic Birbeck granules on electron microscopy. Whole genome analysis for copy number changes and loss of heterozygosity showed a complex karyotype with variable @entity4 . Significant findings included a homozygous deletion at 9p21 involving the @entity8 and loss of heterozygosity at 17p involving @entity7 gene, coupled with a @entity7 missense mutation. Despite reexcision and multiagent systemic chemotherapy, the @entity0 died of @entity1 2 years after diagnosis. This case is an outstanding example of lineage infidelity in a @entity10 and the utilization of comparative genomic hybridization in characterizing its @entity4 .

title: XXXX With Lineage Infidelity/Plasticity: A Diagnostic Challenge and Insight Into the Pathobiology of the Disease.

answer: @entity17


abstract: UNASSIGNED: @entity1 ( @entity1 ) causes significant economic losses in farmed shrimp, where associated mortality in ponds can reach 70%. To explore host-pathogen interactions, a next generation sequencing approach (NGS) using lymphoid organ (LO) tissue from @entity1 -infected @entity3 shrimp was conducted. Preliminary sequence assembly of just the virus showed that there were at least an additional 639 base pairs (bp) at the 5' terminus and 23 nt at 3' terminus as compared to the original description of the @entity1 genome (7561 nt). Northern blot and RT-PCR analysis confirmed the presence of novel sequence at both ends of the genome. Using 5' RACE, 4 additional @entity2 were discovered; 3' RACE confirmed the presence of 22, rather than 23 bp of sequence. Based on these data, the @entity1 genome is 8226 bp in length. Double-stranded RNA was used to trigger RNA interference (RNAi) and suppress expression of the newly revealed genome sections at the 5' end of the @entity1 genome in @entity1 -infected @entity3 . An RNAi trigger targeting a 376 bp length of the 5'UTR did not improve survival of infected shrimp. In contrast, an RNAi trigger that targets a 381 bp sequence in ORF1 improved survival to 82.2% as compared to 2.2% survival in positive control animals. These studies revealed the importance of the new genome sections to produce high titer @entity0 and associated disease and mortality, in infected shrimp.

title: Characterization of newly revealed sequences in the Infectious Myonecrosis Virus genome in XXXX .

answer: @entity3


abstract: INTRODUCTION: @entity4 are associated to @entity5 and anticoagulant treatment is installed according to risk profile. This study aimed to assess the rate of @entity3 events and major bleedings in adults with @entity1 ( @entity1 ) and @entity4 , as well as to determine the predictive value of specific clinical features and two risk scores for @entity5 and @entity2 . METHODS AND RESULTS: In this retrospective study, a total of 229 adult @entity1 @entity0 with @entity4 , were included. Incidence and risk factors of @entity5 were assessed in @entity0 without a mechanical valve (n=191), whereas @entity2 incidence and risk factors were studied in @entity0 receiving @entity6 antagonists (n=164). In 13 @entity0 without a mechanical valve @entity3 events occurred, the first @entity3 event rate per year being 1.4%. A total of 29 @entity0 on @entity6 antagonists suffered from major bleedings, at an annual first event rate of 4.4%. CHA2DS2-VASc score and HAS-BLED score predicted @entity5 and @entity2 risk best in a dichotomized form. At a cut-off of >= 2 for high risk the rate of @entity3 events was 3.0% per year compared to 0.7% for a score of <2 (HR 3.7; 95%-CI 1.2-11.5; p=0.021). A major @entity2 rate of 10.8% per year was found in @entity0 on @entity6 antagonists for HAS-BLED>= 2 as opposed to 3.5% with a score of <2 (HR 2.6; 95%-CI: 1.1-6.6; 0.017). CONCLUSION: In adult @entity1 @entity0 , @entity3 events and major bleedings are important complications of @entity4 and anticoagulant treatment. Assessment of @entity5 and @entity2 risk in this @entity0 group can be performed with dichotomized CHA2DS2-VASc and HAS-BLED scores respectively.

title: Weighing the risks: @entity3 and @entity2 events in adults with XXXX and @entity1 .

answer: @entity4


abstract: INTRODUCTION: @entity4 are associated to @entity5 and anticoagulant treatment is installed according to risk profile. This study aimed to assess the rate of @entity3 events and major bleedings in adults with @entity1 ( @entity1 ) and @entity4 , as well as to determine the predictive value of specific clinical features and two risk scores for @entity5 and @entity2 . METHODS AND RESULTS: In this retrospective study, a total of 229 adult @entity1 @entity0 with @entity4 , were included. Incidence and risk factors of @entity5 were assessed in @entity0 without a mechanical valve (n=191), whereas @entity2 incidence and risk factors were studied in @entity0 receiving @entity6 antagonists (n=164). In 13 @entity0 without a mechanical valve @entity3 events occurred, the first @entity3 event rate per year being 1.4%. A total of 29 @entity0 on @entity6 antagonists suffered from major bleedings, at an annual first event rate of 4.4%. CHA2DS2-VASc score and HAS-BLED score predicted @entity5 and @entity2 risk best in a dichotomized form. At a cut-off of >= 2 for high risk the rate of @entity3 events was 3.0% per year compared to 0.7% for a score of <2 (HR 3.7; 95%-CI 1.2-11.5; p=0.021). A major @entity2 rate of 10.8% per year was found in @entity0 on @entity6 antagonists for HAS-BLED>= 2 as opposed to 3.5% with a score of <2 (HR 2.6; 95%-CI: 1.1-6.6; 0.017). CONCLUSION: In adult @entity1 @entity0 , @entity3 events and major bleedings are important complications of @entity4 and anticoagulant treatment. Assessment of @entity5 and @entity2 risk in this @entity0 group can be performed with dichotomized CHA2DS2-VASc and HAS-BLED scores respectively.

title: Weighing the risks: @entity3 and XXXX events in adults with @entity4 and @entity1 .

answer: @entity2


abstract: INTRODUCTION: @entity4 are associated to @entity5 and anticoagulant treatment is installed according to risk profile. This study aimed to assess the rate of @entity3 events and major bleedings in adults with @entity1 ( @entity1 ) and @entity4 , as well as to determine the predictive value of specific clinical features and two risk scores for @entity5 and @entity2 . METHODS AND RESULTS: In this retrospective study, a total of 229 adult @entity1 @entity0 with @entity4 , were included. Incidence and risk factors of @entity5 were assessed in @entity0 without a mechanical valve (n=191), whereas @entity2 incidence and risk factors were studied in @entity0 receiving @entity6 antagonists (n=164). In 13 @entity0 without a mechanical valve @entity3 events occurred, the first @entity3 event rate per year being 1.4%. A total of 29 @entity0 on @entity6 antagonists suffered from major bleedings, at an annual first event rate of 4.4%. CHA2DS2-VASc score and HAS-BLED score predicted @entity5 and @entity2 risk best in a dichotomized form. At a cut-off of >= 2 for high risk the rate of @entity3 events was 3.0% per year compared to 0.7% for a score of <2 (HR 3.7; 95%-CI 1.2-11.5; p=0.021). A major @entity2 rate of 10.8% per year was found in @entity0 on @entity6 antagonists for HAS-BLED>= 2 as opposed to 3.5% with a score of <2 (HR 2.6; 95%-CI: 1.1-6.6; 0.017). CONCLUSION: In adult @entity1 @entity0 , @entity3 events and major bleedings are important complications of @entity4 and anticoagulant treatment. Assessment of @entity5 and @entity2 risk in this @entity0 group can be performed with dichotomized CHA2DS2-VASc and HAS-BLED scores respectively.

title: Weighing the risks: @entity3 and @entity2 events in adults with @entity4 and XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity4 are associated to @entity5 and anticoagulant treatment is installed according to risk profile. This study aimed to assess the rate of @entity3 events and major bleedings in adults with @entity1 ( @entity1 ) and @entity4 , as well as to determine the predictive value of specific clinical features and two risk scores for @entity5 and @entity2 . METHODS AND RESULTS: In this retrospective study, a total of 229 adult @entity1 @entity0 with @entity4 , were included. Incidence and risk factors of @entity5 were assessed in @entity0 without a mechanical valve (n=191), whereas @entity2 incidence and risk factors were studied in @entity0 receiving @entity6 antagonists (n=164). In 13 @entity0 without a mechanical valve @entity3 events occurred, the first @entity3 event rate per year being 1.4%. A total of 29 @entity0 on @entity6 antagonists suffered from major bleedings, at an annual first event rate of 4.4%. CHA2DS2-VASc score and HAS-BLED score predicted @entity5 and @entity2 risk best in a dichotomized form. At a cut-off of >= 2 for high risk the rate of @entity3 events was 3.0% per year compared to 0.7% for a score of <2 (HR 3.7; 95%-CI 1.2-11.5; p=0.021). A major @entity2 rate of 10.8% per year was found in @entity0 on @entity6 antagonists for HAS-BLED>= 2 as opposed to 3.5% with a score of <2 (HR 2.6; 95%-CI: 1.1-6.6; 0.017). CONCLUSION: In adult @entity1 @entity0 , @entity3 events and major bleedings are important complications of @entity4 and anticoagulant treatment. Assessment of @entity5 and @entity2 risk in this @entity0 group can be performed with dichotomized CHA2DS2-VASc and HAS-BLED scores respectively.

title: Weighing the risks: XXXX and @entity2 events in adults with @entity4 and @entity1 .

answer: @entity3


abstract: UNASSIGNED: The flash visual evoked potential(VEP)is a useful diagnostic modality for visual preservation during surgery. @entity4 is recognized to indicate @entity3 ;however, whether intraoperative VEP can detect visual improvement remains unclear. We describe a @entity6 case with a significant increase in VEP amplitude during surgery. A 67-year-old @entity0 presented with progressive gait disturbance and @entity8 . Head magnetic resonance imaging demonstrated a @entity1 compressing the optic chiasm upward with significant @entity9 . Her Glasgow @entity5 Scale was E3V3M5. Visual fields and acuity could not be examined because of @entity8 , and she could not see/recognize objects on a table. Preoperative VEP showed reproducible waveforms. @entity1 removal by the extended transsphenoidal approach was performed with VEP monitoring. Increased VEP amplitude was observed after dural incision and persisted until the surgery ended. Postoperative VEP waveforms were also reproducible, but visual fields/acuity could not be examined because of @entity2 . Useful visual function was restored, and she became independent in daily life. The histological diagnosis was @entity6 . The @entity0 underwent ventriculo-peritoneal shunting for @entity7 16 days after @entity1 removal. The postoperative course was uneventful and she was transferred to another hospital for rehabilitation. Intraoperative VEP may indicate visual improvement during surgery, which is a useful objective assessment for visual function in @entity0 with @entity8 and @entity2 .

title: [A Significant Increase in Intraoperative Flash Visual Evoked Potential Amplitude during XXXX Surgery-Case Report].

answer: @entity6


abstract: BACKGROUND: @entity9 ( @entity9 ) is an @entity1 affecting skin and mucosae, often triggered by @entity5 . Some @entity0 have a @entity2 associated with antidesmoplakin autoantibodies, but the pathophysiology remains to be elucidated. First-line treatment is antiviral therapy. With treatment failure or in @entity0 without herpes-triggered disease, @entity6 is effective but has neurological side-effects. Alternatives ( @entity7 , immunosuppressant agents) are not codified. For many @entity0 , systemic @entity3 use is chronic. The immunosuppressant drug rituximab (RTX) may be effective. OBJECTIVES: We report five cases of severe chronic @entity9 treated with rituximab (RTX). METHODS: Five @entity0 with severe chronic @entity9 for 9-20  years received RTX after failure or side-effects of several treatments, especially antiviral therapy and @entity6 . All had chronic use of @entity3 . Four patients had antidesmoplakin autoantibodies. RESULTS: Four @entity0 experienced complete or quasi-complete remission of @entity9 with withdrawal of @entity3 and one @entity0 partial remission, for 3-11  months. Disease relapsed in all @entity0 , and three received a second cycle of RTX with shorter duration of efficacy. Two @entity0 received a third cycle, one without efficacy. CONCLUSION: The use of RTX for many @entity4 , especially @entity8 , is increasing. Chronic @entity9 , especially @entity9 associated to antidesmoplakin autoantibodies, is an @entity1 in which the role of B cells is not well understood. However, we report a favourable benefit of RTX treatment for months in five @entity0 with severe disease. RTX could be a therapeutic option in severe, difficult-to-treat @entity9 .

title: Rituximab, a new treatment for difficult-to-treat chronic XXXX ? Five cases.

answer: @entity9


abstract: OBJECTIVE: To estimate the incidence of @entity1 and @entity2 , distribution of pneumococcal serotypes, and antibiotic susceptibility in @entity0 aged 28 days to <60 months. DESIGN: Hospital-based surveillance. SETTING: South Bangalore, India. @entity0 : 9950 @entity0 aged 28 days to <60 months with clinical suspicion of @entity1 or @entity2 . RESULTS: The estimated at-risk population included 224,966 @entity0 <5 years of age. Forty cases of @entity1 were identified. Estimated @entity1 incidence was 17.8/100,000 with incidence being highest among @entity0 aged 6 months to <12 months (49.9/100,000). @entity4 was the most frequent diagnosis (12.5/100,000). Pneumococcal serotypes included: 6A (n=6, 16.7%); 14 (n=5, 13.9%); 5 (n=4, 11.1%); 6B (n=4, 11.1%); 1, 18C, and @entity5 (n=3 each, 8.3%); 9V (n=2, 5.6%); and 3, 4, 10C, 18A, 18F, and 19F (n=1 each, 2.8%). Serotypes 6A, 14, 6B, 1, 18C, @entity5 , 9V, 4, 10C, and 18A showed antibiotic resistance. Clinical @entity2 incidence was 2109/100,000, with incidence being highest among @entity0 aged 28 days to <6 months (5033/100,000). Chest radiograph-confirmed @entity2 incidence was 1114/100,000, with incidence being highest among @entity0 aged 28 days to <6 months (2413/100,000). CONCLUSIONS: Invasive @entity3 and @entity2 were found to be common causes of morbidity in young @entity0 living in South Bangalore, India.

title: Hospital-based Surveillance of XXXX and @entity2 in South Bangalore, India.

answer: @entity1


abstract: OBJECTIVE: To estimate the incidence of @entity1 and @entity2 , distribution of pneumococcal serotypes, and antibiotic susceptibility in @entity0 aged 28 days to <60 months. DESIGN: Hospital-based surveillance. SETTING: South Bangalore, India. @entity0 : 9950 @entity0 aged 28 days to <60 months with clinical suspicion of @entity1 or @entity2 . RESULTS: The estimated at-risk population included 224,966 @entity0 <5 years of age. Forty cases of @entity1 were identified. Estimated @entity1 incidence was 17.8/100,000 with incidence being highest among @entity0 aged 6 months to <12 months (49.9/100,000). @entity4 was the most frequent diagnosis (12.5/100,000). Pneumococcal serotypes included: 6A (n=6, 16.7%); 14 (n=5, 13.9%); 5 (n=4, 11.1%); 6B (n=4, 11.1%); 1, 18C, and @entity5 (n=3 each, 8.3%); 9V (n=2, 5.6%); and 3, 4, 10C, 18A, 18F, and 19F (n=1 each, 2.8%). Serotypes 6A, 14, 6B, 1, 18C, @entity5 , 9V, 4, 10C, and 18A showed antibiotic resistance. Clinical @entity2 incidence was 2109/100,000, with incidence being highest among @entity0 aged 28 days to <6 months (5033/100,000). Chest radiograph-confirmed @entity2 incidence was 1114/100,000, with incidence being highest among @entity0 aged 28 days to <6 months (2413/100,000). CONCLUSIONS: Invasive @entity3 and @entity2 were found to be common causes of morbidity in young @entity0 living in South Bangalore, India.

title: Hospital-based Surveillance of @entity1 and XXXX in South Bangalore, India.

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity4 ) is a rare high-grade variant of @entity2 . Consensus has not been reached on its optimal management. Resection with wide margins is usually recommended, but the effect of margins has been demonstrated by little positive evidence. Moreover, the effectiveness of adjuvant chemo- and/or radiotherapy remains controversial. OBJECTIVES: To describe the clinical characteristics and outcomes of @entity4 of bone and soft tissue, to assess the efficacies of surgery, chemotherapy and radiation, and finally to deliver a more appropriate therapy. MATERIALS AND METHODS: We reviewed EMBASE-, MEDLINE-, Cochrane-, Ovid- and PubMed-based to find out all cases of @entity4 of bone and soft tissue described between April 1994 and April 2014. Description of treatment and regular follow-up was required for each study. Language was restricted to English and Chinese. Issues of age, gender, location, @entity1 , and treatment were all evaluated for each case. Kaplan-Meier Method and Cox Proportional Hazard Regression Model were used in the survival analysis. RESULTS: From the 630 identified publications, 18 meeting the inclusion criteria were selected, involving a total of 107 @entity0 . Based on these data, the 5-, 10-and 20-year overall survival are 55.0%, 43.5% and 15.7% respectively. The 5-, 10-, 20- year event-free survival rates are 45.0%, 27.2% and 8.1%, respectively. Treatment without surgery is associated with poorer overall survival and event-free survival. Negative surgical margins could significantly bring down the local-recurrence rate and are associated with a higher event-free survival rate. Chemotherapy regime based on @entity3 does not benefit the overall survival. The addition of radiation therapy is not significantly associated with the overall or event-free survival. However, we recommend radiation as the salvage therapy for @entity0 with positive margin so as to achieve better local control. CONCLUSIONS: This review shows that surgery is essential in the management of @entity4 of bone and soft tissue. Appropriate adjuvant therapy may reduce local recurrence, but cannot benefit the overall survival.

title: XXXX and soft tissue: a systematic review of 107 @entity0 in the past 20 years.

answer: @entity5


abstract: BACKGROUND: @entity5 ( @entity4 ) is a rare high-grade variant of @entity2 . Consensus has not been reached on its optimal management. Resection with wide margins is usually recommended, but the effect of margins has been demonstrated by little positive evidence. Moreover, the effectiveness of adjuvant chemo- and/or radiotherapy remains controversial. OBJECTIVES: To describe the clinical characteristics and outcomes of @entity4 of bone and soft tissue, to assess the efficacies of surgery, chemotherapy and radiation, and finally to deliver a more appropriate therapy. MATERIALS AND METHODS: We reviewed EMBASE-, MEDLINE-, Cochrane-, Ovid- and PubMed-based to find out all cases of @entity4 of bone and soft tissue described between April 1994 and April 2014. Description of treatment and regular follow-up was required for each study. Language was restricted to English and Chinese. Issues of age, gender, location, @entity1 , and treatment were all evaluated for each case. Kaplan-Meier Method and Cox Proportional Hazard Regression Model were used in the survival analysis. RESULTS: From the 630 identified publications, 18 meeting the inclusion criteria were selected, involving a total of 107 @entity0 . Based on these data, the 5-, 10-and 20-year overall survival are 55.0%, 43.5% and 15.7% respectively. The 5-, 10-, 20- year event-free survival rates are 45.0%, 27.2% and 8.1%, respectively. Treatment without surgery is associated with poorer overall survival and event-free survival. Negative surgical margins could significantly bring down the local-recurrence rate and are associated with a higher event-free survival rate. Chemotherapy regime based on @entity3 does not benefit the overall survival. The addition of radiation therapy is not significantly associated with the overall or event-free survival. However, we recommend radiation as the salvage therapy for @entity0 with positive margin so as to achieve better local control. CONCLUSIONS: This review shows that surgery is essential in the management of @entity4 of bone and soft tissue. Appropriate adjuvant therapy may reduce local recurrence, but cannot benefit the overall survival.

title: @entity5 and soft tissue: a systematic review of 107 XXXX in the past 20 years.

answer: @entity0


abstract: Previous studies have described the existence of high mobility group (HMG)-like proteins in macronuclei of the ciliated protozoan, @entity6 (Hamana, K., and K. Iwai, 1979, J. Biochem. [Tokyo], 69:1097-1111; Levy-Wilson, B., M. S. Denker, and E. Ito, 1983, Biochemistry, 22:1715-1721). In this report, two of these proteins, LG-1 and LG-2, have been further characterized. Polyclonal antibodies raised against LG-1 and LG-2 fail to cross react with each other or any other macronuclear polypeptide in immunoblotting analyses. As well, LG-1 and LG-2 antibodies do not react with @entity0 thymus, @entity4 , or @entity1 HMG proteins. Consistent with these results, a 47 @entity3 -terminal sequence of LG-1 has been determined that shows limited homology to both @entity0 thymus @entity7 and HMGs 14 and 17. Two internal sequences of V8 protease-generated peptides from LG-2 have been determined, and these do not share any homology to the LG-1 sequence or any other sequenced HMG proteins. Comparison of the partial sequences of LG-1 and LG-2 with the complete @entity2 sequence of the @entity6 histone H1 (Wu, M., C. D. Allis, R. Richman, R. G. Cook, and M. A. Gorovsky, 1986, Proc. Natl. Acad. Sci. USA, 83:8674-8678) rules out the possibility that LG-1 and LG-2 are proteolytically derived from H1, the other major macronuclear @entity5 -soluble protein. Interestingly, however, both LG-1 and LG-2 are efficiently extracted from macronuclei by elutive intercalation (Schr  ter, H., G. Maier, H. Ponsting, and A. Nordheim, 1985, Embo (Eur. Mol. Biol. Organ.) J., 4:3867-3872), suggesting that both may share yet undetermined properties with HMGs 14 and 17 of higher eukaryotes. Examination of the pattern of LG-1 and LG-2 synthesis during the sexual phase of the life cycle, conjugation, demonstrates that the synthesis of LG-1 and LG-2 is coordinately increased from basal levels during the differentiation of new macronuclei (7-13 h), suggesting that both of these proteins play a role in determining a macronuclear phenotype. However, a specific induction of LG-2 synthesis is detected in early stages of conjugation (meiotic prophase, 1-4 h), leading to maximal synthesis of LG-2 at 3 h. Interestingly, the early induction of LG-2 synthesis closely parallels the hyperphosphorylation of histone H1. Taken together, these data suggest that LG-1 and LG-2 are not strongly related to each other or to higher eukaryotic HMG proteins.(ABSTRACT TRUNCATED AT 400 WORDS)

title: XXXX contain two distinct and unusual high mobility group (HMG)-like proteins.

answer: @entity6


abstract: UNASSIGNED: @entity1 ( @entity1 ) is characterized by @entity0 . The notion that dysfunctions in neural circuits involved in sharing another's affect explain these deficits is appealing, but has received only modest experimental support. Here we evaluated a complex paradigm on the vicarious social @entity2 of embarrassment to probe social deficits in @entity1 as to whether it is more potent than paradigms currently in use. To do so we acquired pupillometry and fMRI in young adults with @entity1 and matched healthy controls. During a simple vicarious physical @entity2 task no differences emerged between groups in behavior, pupillometry, and neural activation of the anterior insula ( @entity4 ) and anterior cingulate cortex (ACC). In contrast, processing complex vicarious social @entity2 yielded reduced responses in @entity1 on all physiological measures of sharing another's affect. The reduced activity within the @entity4 was thereby explained by the severity of @entity3 in the social and affective domain. Additionally, behavioral responses lacked correspondence with the anterior cingulate and anterior insula cortex activity found in controls. Instead, behavioral responses in @entity1 were associated with hippocampal activity. The observed dissociation echoes the clinical observations that deficits in @entity1 are most pronounced in complex social situations and simple tasks may not probe the dysfunctions in neural pathways involved in sharing affect. Our results are highly relevant because individuals with @entity1 may have preserved abilities to share another's physical @entity2 but still have problems with the vicarious representation of more complex emotions that matter in life. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

title: Evidence from pupillometry and fMRI indicates @entity2 but not physical @entity2 in XXXX .

answer: @entity3


abstract: UNASSIGNED: @entity1 ( @entity1 ) is characterized by @entity0 . The notion that dysfunctions in neural circuits involved in sharing another's affect explain these deficits is appealing, but has received only modest experimental support. Here we evaluated a complex paradigm on the vicarious social @entity2 of embarrassment to probe social deficits in @entity1 as to whether it is more potent than paradigms currently in use. To do so we acquired pupillometry and fMRI in young adults with @entity1 and matched healthy controls. During a simple vicarious physical @entity2 task no differences emerged between groups in behavior, pupillometry, and neural activation of the anterior insula ( @entity4 ) and anterior cingulate cortex (ACC). In contrast, processing complex vicarious social @entity2 yielded reduced responses in @entity1 on all physiological measures of sharing another's affect. The reduced activity within the @entity4 was thereby explained by the severity of @entity3 in the social and affective domain. Additionally, behavioral responses lacked correspondence with the anterior cingulate and anterior insula cortex activity found in controls. Instead, behavioral responses in @entity1 were associated with hippocampal activity. The observed dissociation echoes the clinical observations that deficits in @entity1 are most pronounced in complex social situations and simple tasks may not probe the dysfunctions in neural pathways involved in sharing affect. Our results are highly relevant because individuals with @entity1 may have preserved abilities to share another's physical @entity2 but still have problems with the vicarious representation of more complex emotions that matter in life. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

title: Evidence from pupillometry and fMRI indicates XXXX but not physical @entity2 in @entity3 .

answer: @entity2


abstract: UNASSIGNED: @entity1 ( @entity1 ) is characterized by @entity0 . The notion that dysfunctions in neural circuits involved in sharing another's affect explain these deficits is appealing, but has received only modest experimental support. Here we evaluated a complex paradigm on the vicarious social @entity2 of embarrassment to probe social deficits in @entity1 as to whether it is more potent than paradigms currently in use. To do so we acquired pupillometry and fMRI in young adults with @entity1 and matched healthy controls. During a simple vicarious physical @entity2 task no differences emerged between groups in behavior, pupillometry, and neural activation of the anterior insula ( @entity4 ) and anterior cingulate cortex (ACC). In contrast, processing complex vicarious social @entity2 yielded reduced responses in @entity1 on all physiological measures of sharing another's affect. The reduced activity within the @entity4 was thereby explained by the severity of @entity3 in the social and affective domain. Additionally, behavioral responses lacked correspondence with the anterior cingulate and anterior insula cortex activity found in controls. Instead, behavioral responses in @entity1 were associated with hippocampal activity. The observed dissociation echoes the clinical observations that deficits in @entity1 are most pronounced in complex social situations and simple tasks may not probe the dysfunctions in neural pathways involved in sharing affect. Our results are highly relevant because individuals with @entity1 may have preserved abilities to share another's physical @entity2 but still have problems with the vicarious representation of more complex emotions that matter in life. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

title: Evidence from pupillometry and fMRI indicates @entity2 but not physical XXXX in @entity3 .

answer: @entity2


abstract: Arthropod molt is coordinated through the interplay between ecdysteroids and neuropeptide hormones. In crustaceans, changes in the activity of Y-organs during the molt cycle have been regulated by molt-inhibiting hormone (MIH) and @entity2 ( @entity2 ). @entity1 has been known of the mode of direct effects of ecdysteroids on the levels of MIH and @entity2 in the @entity0 during the molt cycle. This study focused on a putative feedback of ecdysteroids on the expression levels of MIH transcripts using in vitro incubation study with ecdysteroids and in vivo RNAi in the @entity3 , @entity3 . Our results show a specific expression of ecdysone receptor (EcR) in which EcR1 is the major isoform in @entity0 . The initial elevation of MIH expression at the early premolt stages is replicated by in vitro incubations of @entity0 with ecdysteroids that mimic the intrinsic conditions of D0 stage: the concentration (75 ng/ml) and composition (ponasterone A and 20-hydroxyecdysone at a 3:1 (w:w) ratio). Additionally, multiple injections of EcR1-dsRNA reduce MIH expression by 67%, compared to the controls. Our data provide evidence on a putative feedback mechanism of hormonal regulation during molting cycle, specifically how the molt cycle is repeated during the life cycle of crustaceans. The elevated concentrations of ecdysteroids at early premolt stage may act positively on the levels of MIH expression in the @entity0 . Subsequently, the increased MIH titers in the hemolymph at postmolt would inhibit the synthesis and release of ecdysteroids by Y-organs, resulting in re-setting the subsequent molt cycle.

title: Ecdysteroids Regulate the Levels of Molt-Inhibiting Hormone (MIH) Expression in the XXXX , @entity3 .

answer: @entity3


abstract: Arthropod molt is coordinated through the interplay between ecdysteroids and neuropeptide hormones. In crustaceans, changes in the activity of Y-organs during the molt cycle have been regulated by molt-inhibiting hormone (MIH) and @entity2 ( @entity2 ). @entity1 has been known of the mode of direct effects of ecdysteroids on the levels of MIH and @entity2 in the @entity0 during the molt cycle. This study focused on a putative feedback of ecdysteroids on the expression levels of MIH transcripts using in vitro incubation study with ecdysteroids and in vivo RNAi in the @entity3 , @entity3 . Our results show a specific expression of ecdysone receptor (EcR) in which EcR1 is the major isoform in @entity0 . The initial elevation of MIH expression at the early premolt stages is replicated by in vitro incubations of @entity0 with ecdysteroids that mimic the intrinsic conditions of D0 stage: the concentration (75 ng/ml) and composition (ponasterone A and 20-hydroxyecdysone at a 3:1 (w:w) ratio). Additionally, multiple injections of EcR1-dsRNA reduce MIH expression by 67%, compared to the controls. Our data provide evidence on a putative feedback mechanism of hormonal regulation during molting cycle, specifically how the molt cycle is repeated during the life cycle of crustaceans. The elevated concentrations of ecdysteroids at early premolt stage may act positively on the levels of MIH expression in the @entity0 . Subsequently, the increased MIH titers in the hemolymph at postmolt would inhibit the synthesis and release of ecdysteroids by Y-organs, resulting in re-setting the subsequent molt cycle.

title: Ecdysteroids Regulate the Levels of Molt-Inhibiting Hormone (MIH) Expression in the @entity3 , XXXX .

answer: @entity3


abstract: Omalizumab is a humanized anti-IgE antibody that inhibits the binding of IgE to its receptors on mast cells and basophils, thus blocking the IgE-mediated release of inflammatory mediators from these cells. Omalizumab binds to the Fc domains of IgE in proximity to the binding site of the high-affinity IgE receptor @entity2 , but the epitope and the mechanisms and conformations governing the recognition remain unknown. In order to elucidate the molecular mechanism of its anti-IgE activity, the aim was to analyse the interaction of omalizumab with @entity0 IgE. Therefore, IgE Fc C   2-4 was recombinantly produced in @entity0 HEK-293 cells. Functionality of the IgE Fc was proven by ELISA and mediator-release assays. Omalizumab IgG was cleaved with papain and the resulting @entity1 was purified by ion-exchange chromatography. The complex of IgE Fc with omalizumab was prepared by size-exclusion chromatography. However, crystals containing the complex were not obtained, suggesting that the process of crystallization favoured the dissociation of the two proteins. Instead, two structures of the omalizumab @entity1 with maximum resolutions of 1.9 and 3.0      were obtained. The structures reveal the arrangement of the CDRs and the position of omalizumab residues known from prior functional studies to be involved in IgE binding. Thus, the structure of omalizumab provides the structural basis for understanding the function of omalizumab, allows optimization of the procedure for complex crystallization and poses questions about the conformational requirements for anti-IgE activity.

title: Structure of the omalizumab XXXX .

answer: @entity1


abstract: BACKGROUND: Comprehensive understanding of the determinants of health service use (HSU) by older @entity0 with @entity2 is essential for health service planning for an ageing global population. This study aimed to determine the extent to which depressive symptom severity and functioning are associated with HSU by older @entity0 with @entity2 in low and middle income countries (LMICs). METHODS: A cross-sectional analysis of the 10/66 @entity1 Research Group population-based surveys dataset. @entity0 (n = 4590) were those aged 65 or older, in the clinical range for @entity2 (defined as scoring four or more on the @entity3 -D), living in 13 urban and/or rural catchment areas in nine LMICs. Associations were calculated using Poisson regression and random-effects meta-analysis. RESULTS: After adjustment for confounding variables, ( @entity3 -D) depressive symptom severity was significantly associated with "any community HSU" (Pooled Prevalence Ratios = 1.02; 95% CI = 1.01-1.03) but not hospital admission. Conversely, after adjustment, (WHODAS-II) functioning was significantly associated with hospital admission (Pooled PR = 1.14; 95% CI = 1.02-1.26) but not "any community HSU". CONCLUSIONS: Depressive symptom severity does not explain a large proportion of the variance in HSU by older @entity0 with @entity2 in LMICs. The association of functioning with this HSU is worthy of further investigation. In LMICs, variables related to accessibility may be more important correlates of HSU than variables directly related to health problems.

title: Cross-Sectional Associations of Depressive Symptom Severity and Functioning with Health Service Use by Older XXXX in Low-and-Middle Income Countries.

answer: @entity0


abstract: @entity2 and @entity1 ( @entity1 ) are two increasingly common and important obstetric complications that are associated with severe long-term health risks to mothers and babies. @entity5 , which is increased in @entity2 and @entity1 pregnancies, plays an important role in the pathophysiology of these two pregnancy complications. In non-pregnant tissues, endoplasmic (ER) stress is increased in @entity1 and can induce @entity5 via inflammasome activation. The aim of this study was to determine whether ER stress is increased in omental adipose tissue of @entity0 with @entity1 , and if ER stress can also upregulate inflammasome-dependent secretion of @entity5 . ER stress markers @entity8 , @entity6 and @entity9 s were significantly increased in adipose tissue of @entity2 compared to lean pregnant @entity0 . ER stress was also increased in adipose tissue of @entity0 with @entity1 compared to BMI-matched normal glucose tolerant (NGT) @entity0 . Thapsigargin, an ER stress activator, induced upregulated secretion of mature @entity4 and @entity5 in @entity0 omental adipose tissue explants primed with @entity7 , the viral dsRNA analogue poly(I:C) or the pro-inflammatory cytokine @entity3 . Inhibition of capase-1 with Ac-YVAD-CHO resulted in decreased @entity4 and @entity5 secretion, whereas inhibition of @entity10 with carbenoxolone suppressed @entity5 secretion only. Treatment with anti- @entity1 drugs metformin and glibenclamide also reduced @entity4 and @entity5 secretion in infection and cytokine-primed adipose tissue. In conclusion, this study has demonstrated ER stress to activate the inflammasome in pregnant adipose tissue. Therefore, increased ER stress may contribute towards the pathophysiology of @entity2 in pregnancy and @entity1 .

title: Endoplasmic reticulum stress is increased in adipose tissue of XXXX with gestational diabetes.

answer: @entity0


abstract: INTRODUCTION: The antidiabetic drug metformin exhibits potential anticancer properties that are believed to involve both direct (insulin-independent) and indirect (insulin-dependent) actions. Direct effects are linked to activation of @entity9 ( @entity9 ) and an inhibition of @entity1 target of rapamycin @entity5 signaling, and indirect effects are mediated by reductions in circulating insulin, leading to reduced @entity8 ( @entity8 )-mediated signaling. However, the in vivo impact of metformin on cancer cell signaling and the factors governing sensitivity in @entity1 remain unknown. METHODS: We conducted a neoadjuvant, single-arm, "window of opportunity" trial to examine the clinical and biological effects of metformin on @entity1 with @entity0 . @entity1 with untreated @entity0 who did not have @entity3 were given 500  mg of metformin three times daily for >= 2  weeks after diagnostic biopsy until surgery. Fasting @entity2 samples were collected at diagnosis and surgery. Blood glucose and insulin were assayed to assess the physiologic effects of metformin, and immunohistochemical analysis of @entity2 was used to characterize cellular markers before and after treatment. RESULTS: Levels of @entity8 expression decreased significantly in @entity2 (P   =   0.04), as did the phosphorylation status of protein kinase B (PKB)/Akt (S473), @entity7 ( @entity4 , T202/Y204), @entity9 (T172) and acetyl coenzyme A carboxylase (S79) (P   =   0.0001, P   <   0.0001, P   <   0.005 and P   =   0.02, respectively). All @entity2 expressed @entity6 , with 90% (35 of 39) exhibiting an Allred score of 5 or higher. CONCLUSIONS: Reduced PKB/Akt and @entity4 phosphorylation, coupled with decreased insulin and @entity8 levels, suggest insulin-dependent effects are important in the clinical setting. These results are consistent with beneficial anticancer effects of metformin and highlight key factors involved in sensitivity, which could be used to identify @entity1 with @entity0 who may be responsive to metformin-based therapies. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00897884. Registered 8 May 2009.

title: Changes in XXXX signaling underlie neoadjuvant metformin administration in @entity0 : a prospective window of opportunity neoadjuvant study.

answer: @entity8


abstract: INTRODUCTION: The antidiabetic drug metformin exhibits potential anticancer properties that are believed to involve both direct (insulin-independent) and indirect (insulin-dependent) actions. Direct effects are linked to activation of @entity9 ( @entity9 ) and an inhibition of @entity1 target of rapamycin @entity5 signaling, and indirect effects are mediated by reductions in circulating insulin, leading to reduced @entity8 ( @entity8 )-mediated signaling. However, the in vivo impact of metformin on cancer cell signaling and the factors governing sensitivity in @entity1 remain unknown. METHODS: We conducted a neoadjuvant, single-arm, "window of opportunity" trial to examine the clinical and biological effects of metformin on @entity1 with @entity0 . @entity1 with untreated @entity0 who did not have @entity3 were given 500  mg of metformin three times daily for >= 2  weeks after diagnostic biopsy until surgery. Fasting @entity2 samples were collected at diagnosis and surgery. Blood glucose and insulin were assayed to assess the physiologic effects of metformin, and immunohistochemical analysis of @entity2 was used to characterize cellular markers before and after treatment. RESULTS: Levels of @entity8 expression decreased significantly in @entity2 (P   =   0.04), as did the phosphorylation status of protein kinase B (PKB)/Akt (S473), @entity7 ( @entity4 , T202/Y204), @entity9 (T172) and acetyl coenzyme A carboxylase (S79) (P   =   0.0001, P   <   0.0001, P   <   0.005 and P   =   0.02, respectively). All @entity2 expressed @entity6 , with 90% (35 of 39) exhibiting an Allred score of 5 or higher. CONCLUSIONS: Reduced PKB/Akt and @entity4 phosphorylation, coupled with decreased insulin and @entity8 levels, suggest insulin-dependent effects are important in the clinical setting. These results are consistent with beneficial anticancer effects of metformin and highlight key factors involved in sensitivity, which could be used to identify @entity1 with @entity0 who may be responsive to metformin-based therapies. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00897884. Registered 8 May 2009.

title: Changes in @entity8 signaling underlie neoadjuvant metformin administration in XXXX : a prospective window of opportunity neoadjuvant study.

answer: @entity0


abstract: BACKGROUND: Moderately increased @entity4 (formerly called microalbuminuria) is widely recognized as a predictor of @entity2 . However, it is not clear whether this observation is applicable to the Asian population, as studies leading to this conclusion were conducted on Western populations. The aim of this study was to examine the hypothesis if moderately increased @entity4 could be an independent predictor of cardiovascular mortality and morbidity in the Japanese population. METHODS AND RESULTS: The study population consisted of 3093 inhabitants of Watari, Miyagi Prefecture, who participated in an annual health check-up in 2009. We examined anthropometry, sitting blood pressure, fasting blood sample, and urine albumin-to- @entity5 ratio (UACR). After baseline assessment, subjects were followed prospectively for up to 60 months. The incidence of major @entity2 ( @entity1 , @entity3 , revascularization, and @entity2 ) was determined based on death certificate records or medical claims sent to the National Health Insurance of Japan. Follow-up was discontinued for those who reached 75 years of age because they were moved to a different medical insurance system. We observed 57 @entity2 during a mean follow-up period of 47.8 months. The cumulative incidence rate for major @entity2 was significantly higher in @entity0 with moderately increased @entity4 (UACR 30-299 mg/ @entity6 ) than in those with normoalbuminuria (UACR <30 mg/ @entity6 ) (6.4% vs. 2.2%, p = 0.0002 by log-rank test). Multivariate Cox proportional hazards analyses have revealed that moderately increased @entity4 is an independent predictor of @entity2 (HR 2.386, 95% CI: 1.120-4.390). CONCLUSIONS: Moderately increased @entity4 is an independent predictor of @entity2 in the general Japanese population under 75 years of age.

title: Moderately Increased XXXX Is an Independent Risk Factor of Cardiovascular Events in the General Japanese Population under 75 Years of Age: The Watari Study.

answer: @entity4


abstract: BACKGROUND: The long-term physiologic and oncologic outcomes of treatment for inferior vena cava (IVC) @entity3 in @entity0 with malignant @entity1 are unclear. METHODS: We conducted a retrospective review of @entity0 with @entity3 treated at our institution between January 1996 and December 2011. Extent of @entity1 @entity3 was classified using the Hinman system. Disease stage, management, and oncologic and physiologic outcomes and complications were evaluated. RESULTS: We identified 15 @entity0 (median age, 4.7years): 12 with @entity5 , 2 with @entity6 , and 1 with @entity4 . Neoadjuvant chemotherapy changed Hinman levels in 2 (13%) @entity0 . IVC @entity3 resection was complete in 6 (40%) @entity0 , partial in 7 (47%) @entity0 , and not performed in 1 (6.7%) @entity0 . On follow-up imaging, 8 (53%) @entity0 ' IVCs were patent, 6 (40%) had residual @entity3 , and 1 (6.7%) was surgically interrupted. Three (20%) @entity0 had perioperative complications, and 2 (13%) experienced transient effects related to @entity2 . CONCLUSIONS: Surgical management of @entity1 @entity3 in the vena cava of @entity0 with solid @entity1 is challenging. Evidence on which to base strong treatment recommendations is lacking. Few long-term physiologic complications were observed.

title: Long-term physiologic and oncologic outcomes of @entity3 in XXXX .

answer: @entity1


abstract: BACKGROUND: The long-term physiologic and oncologic outcomes of treatment for inferior vena cava (IVC) @entity3 in @entity0 with malignant @entity1 are unclear. METHODS: We conducted a retrospective review of @entity0 with @entity3 treated at our institution between January 1996 and December 2011. Extent of @entity1 @entity3 was classified using the Hinman system. Disease stage, management, and oncologic and physiologic outcomes and complications were evaluated. RESULTS: We identified 15 @entity0 (median age, 4.7years): 12 with @entity5 , 2 with @entity6 , and 1 with @entity4 . Neoadjuvant chemotherapy changed Hinman levels in 2 (13%) @entity0 . IVC @entity3 resection was complete in 6 (40%) @entity0 , partial in 7 (47%) @entity0 , and not performed in 1 (6.7%) @entity0 . On follow-up imaging, 8 (53%) @entity0 ' IVCs were patent, 6 (40%) had residual @entity3 , and 1 (6.7%) was surgically interrupted. Three (20%) @entity0 had perioperative complications, and 2 (13%) experienced transient effects related to @entity2 . CONCLUSIONS: Surgical management of @entity1 @entity3 in the vena cava of @entity0 with solid @entity1 is challenging. Evidence on which to base strong treatment recommendations is lacking. Few long-term physiologic complications were observed.

title: Long-term physiologic and oncologic outcomes of XXXX in @entity1 .

answer: @entity3


abstract: BACKGROUND: The initial treatment of acute @entity2 critically affects @entity0 outcome. @entity0 outcome may also be associated with the day of hospital admission due to differences in the number of the hospital staff between weekdays and weekends. We aimed to assess the effect of weekend admission on in-hospital mortality among @entity0 with @entity2 in Japan. METHODS: We analyzed @entity0 with @entity2 from a large nationwide administrative dataset. The @entity0 were grouped according to the treatment ward to which they were initially admitted: a general medical ward (GMW) or an intensive or @entity1 care unit (S-ICU). The primary outcome, in-hospital mortality, was compared between the @entity0 admitted on a weekday versus weekend according to the initial treatment ward. A generalized estimated equation was applied for multivariate analysis. RESULTS: In total, 47,885 @entity0 were included in the study. Of these @entity0 , 32.0% were admitted to an S-ICU and 27.8% were admitted to a GMW on a weekend. The estimated in-hospital mortality rate was significantly higher among the @entity0 admitted to a GMW on a weekend compared with those admitted on a weekday (7.9% versus 7.0%), but this difference was not significant after adjusting for the @entity0 ' background characteristics. The estimated in-hospital mortality rates of the @entity0 admitted to an S-ICU were similar between weekend and weekday admissions (10.0% versus 9.9%). CONCLUSIONS: No significant effect of weekend admission in-hospital mortality was observed in our study population regardless of the initial treatment ward.

title: Weekend versus Weekday Admission and In-Hospital Mortality from XXXX in Japan.

answer: @entity2


abstract: PURPOSE: To compare the efficacy of 2 prophylaxis regimens before @entity1 surgery using topical antibiotics (1 hour before surgery versus the day before), both with @entity3 , with regard to reducing the preoperative conjunctival bacterial load. SETTING: Tertiary ophthalmic referral center, Munich, Germany. DESIGN: Prospective comparative case series. METHODS: Eyes were treated with topical antibiotics and their conjunctival sac flush irrigated using 10 mL of @entity3 1.0%. All eyes were randomized to receive either 4 applications of topical 3500 IU/mL neomycin @entity2 /6000 IU/mL @entity5 sulfate within 1 hour preoperatively (Group 1) or on the day before surgery (Group 2). Conjunctival specimens were obtained at 4 timepoints: T0C untreated fellow eye (control), T0 surgery eye (after antibiotic prophylaxis but before @entity3 irrigation), T1 after @entity3 , and T2 at the conclusion of surgery. All specimens were inoculated onto blood and @entity4 -blood agar and into thioglycollate broth. RESULTS: One hundred thirty-three eyes of 133 consecutive @entity0 were included (Group 1, 64 eyes; Group 2, 69 eyes). The antibiotic regimens were equally effective in reducing the aerobic and microaerophilic conjunctival flora (Group 1, P=.028; Group 2, P=.000), but had no significant effect on anaerobic bacteria (Group 1, P=.201; Group 2, P=.117). Flush irrigation of the conjunctival sac using 10.0 mL @entity3 1.0% significantly decreased the conjunctival bacterial load in both groups. CONCLUSION: Topical neomycin/ @entity5 was equally effective in reducing the conjunctival bacterial load whether given 1 day or 1 hour before surgery. The greatest effect was achieved by irrigating the conjunctival sac using @entity3 . FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Comparison of 1-day versus 1-hour application of topical neomycin/ XXXX before @entity1 surgery.

answer: @entity5


abstract: PURPOSE: To compare the efficacy of 2 prophylaxis regimens before @entity1 surgery using topical antibiotics (1 hour before surgery versus the day before), both with @entity3 , with regard to reducing the preoperative conjunctival bacterial load. SETTING: Tertiary ophthalmic referral center, Munich, Germany. DESIGN: Prospective comparative case series. METHODS: Eyes were treated with topical antibiotics and their conjunctival sac flush irrigated using 10 mL of @entity3 1.0%. All eyes were randomized to receive either 4 applications of topical 3500 IU/mL neomycin @entity2 /6000 IU/mL @entity5 sulfate within 1 hour preoperatively (Group 1) or on the day before surgery (Group 2). Conjunctival specimens were obtained at 4 timepoints: T0C untreated fellow eye (control), T0 surgery eye (after antibiotic prophylaxis but before @entity3 irrigation), T1 after @entity3 , and T2 at the conclusion of surgery. All specimens were inoculated onto blood and @entity4 -blood agar and into thioglycollate broth. RESULTS: One hundred thirty-three eyes of 133 consecutive @entity0 were included (Group 1, 64 eyes; Group 2, 69 eyes). The antibiotic regimens were equally effective in reducing the aerobic and microaerophilic conjunctival flora (Group 1, P=.028; Group 2, P=.000), but had no significant effect on anaerobic bacteria (Group 1, P=.201; Group 2, P=.117). Flush irrigation of the conjunctival sac using 10.0 mL @entity3 1.0% significantly decreased the conjunctival bacterial load in both groups. CONCLUSION: Topical neomycin/ @entity5 was equally effective in reducing the conjunctival bacterial load whether given 1 day or 1 hour before surgery. The greatest effect was achieved by irrigating the conjunctival sac using @entity3 . FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Comparison of 1-day versus 1-hour application of topical neomycin/ @entity5 before XXXX surgery.

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) may indirectly influence the outcome of @entity0 with @entity3 . AIM: The aim of this study was to assess the influence of cardiac rehabilitation (CR) on endothelial function in @entity0 after @entity4 ( @entity4 ). METHODS: 29 @entity0 scheduled for CR were included to the study. CR began at least 4 weeks after @entity4 and consisted of 12 or 24 training sessions. Endothelial function assessment was performed, before and after CR, using Reactive @entity2 Peripheral Arterial Tonometry. RESULTS: Before the CR, @entity1 was diagnosed in 16 of 29 (55,2%) @entity0 . A total of 25 @entity0 had two assessments of endothelial function: before and after CR. In univariate analysis the factors of negative response of endothelial function to CR were: higher baseline @entity2 index (lnRHI) (OR for positive response to CR: 0.01; 95% CI: 0.00-0.33; p=0.01) and higher, peak serum troponin I level during index hospitalization (OR: 0.97; 95% CI: 0.94-1.00; p=0.04). The independent, negative predictor of response to CR was lnRHI (OR: 0.01; 95% CI: 0.01-0.16; p=0.03). @entity0 training for 24 sessions (n=16) had similar lnRHI changes as @entity0 training for 12 sessions (n=9) [0.16 (-0.06-0.30) vs. 0.10 (0.05-0.15); p=0.44, respectively]. CONCLUSIONS: @entity1 is frequent abnormality in @entity4 survivors. Despite the lack of statistically significant improvement of endothelial function after CR in analyzed group of @entity0 , some factors can influence the efficacy of this type of physical activity. The best effect of CR on endothelial function was observed in @entity0 with baseline @entity1 .

title: Impact of physical training on endothelial function in XXXX survivors-pilot study.

answer: @entity4


abstract: INTRODUCTION: @entity3 ( @entity3 ) is a rare, but serious complication after spinal anesthesia. It is often related to the presence of predisposing factors, such as pregnancy, puerperium, oral contraceptive use, and @entity1 . @entity2 is the most common symptom. We describe a case of a @entity0 who underwent spinal anesthesia who had postoperative @entity2 complicated with @entity3 . CASE REPORT: Male @entity0 , 30 years old, ASA 1, who underwent uneventful arthroscopic knee surgery under spinal anesthesia. Forty-eight hours after the procedure, the @entity0 showed frontal, @entity2 that improved when positioned supine. Diagnosis of @entity7 was made in the general emergency room, and he received symptomatic medication. In subsequent days, the @entity2 worsened with holocranial location and with little improvement in the supine position. The @entity0 presented with left @entity6 followed by @entity4 . He underwent magnetic resonance venography; diagnosed with @entity3 . Analysis of procoagulant factors identified the presence of lupus anticoagulant antibody. The patient received anticonvulsants and anticoagulants and was discharged eight days without sequelae. DISCUSSION: Any @entity0 presenting with @entity2 after spinal anesthesia, which intensifies after a plateau, loses its orthostatic characteristic or become too long, should undergo imaging tests to rule out more serious complications, such as @entity3 . The loss of cerebrospinal fluid leads to dilation and @entity8 that, coupled with the traction caused by the upright position, can lead to TVC in some @entity0 with @entity5 .

title: [ XXXX after spinal anesthesia: case report].

answer: @entity3


abstract: BACKGROUND: Sinonasal @entity3 ( @entity3 ) is a rare @entity1 of the nasal cavities and paranasal sinuses. It is destructive or bone-remodeling, tends to recur after surgical resection, and has a significant malignant potential. The present study aimed to perform a retrospective analysis of @entity0 with @entity2 ( @entity2 ) arising from @entity3 , including characteristics, survival outcome, and predictors of associated @entity1 . METHODS: The medical records of 213 @entity0 diagnosed with @entity3 from January 1970 to January 2014 were retrospectively reviewed. Eighty-seven @entity0 were diagnosed with @entity2 / @entity3 ; their clinical characteristics, treatments, and survival outcomes were analyzed. RESULTS: Of the 87 @entity0 with @entity2 / @entity3 , the 5- and 10-year overall survival outcomes were 39.6% and 31.8%, respectively. Twenty-nine of these @entity0 received surgery and 58 received combined surgery and radiation. Of the @entity0 with stages III-IV, the 5-year survival rate was 30.7% for those treated with surgery only and 39.9% for those given the combination treatment (P = 0.849). Factors associated with significantly poor prognosis were @entity1 , or with cranial base and orbit invasion. Age, synchronous or @entity1 , and pathological stage were independent risk factors for mortality, shown by multivariate analysis. CONCLUSION: @entity0 with @entity2 / @entity3 had low overall survival outcomes. Advanced age, stage, and @entity1 are the main factors affecting prognosis. Treatment planning should consider high-risk factors to improve survival outcome.

title: Survival Outcome of XXXX Arising from Sinonasal @entity3 .

answer: @entity2


abstract: BACKGROUND: Sinonasal @entity3 ( @entity3 ) is a rare @entity1 of the nasal cavities and paranasal sinuses. It is destructive or bone-remodeling, tends to recur after surgical resection, and has a significant malignant potential. The present study aimed to perform a retrospective analysis of @entity0 with @entity2 ( @entity2 ) arising from @entity3 , including characteristics, survival outcome, and predictors of associated @entity1 . METHODS: The medical records of 213 @entity0 diagnosed with @entity3 from January 1970 to January 2014 were retrospectively reviewed. Eighty-seven @entity0 were diagnosed with @entity2 / @entity3 ; their clinical characteristics, treatments, and survival outcomes were analyzed. RESULTS: Of the 87 @entity0 with @entity2 / @entity3 , the 5- and 10-year overall survival outcomes were 39.6% and 31.8%, respectively. Twenty-nine of these @entity0 received surgery and 58 received combined surgery and radiation. Of the @entity0 with stages III-IV, the 5-year survival rate was 30.7% for those treated with surgery only and 39.9% for those given the combination treatment (P = 0.849). Factors associated with significantly poor prognosis were @entity1 , or with cranial base and orbit invasion. Age, synchronous or @entity1 , and pathological stage were independent risk factors for mortality, shown by multivariate analysis. CONCLUSION: @entity0 with @entity2 / @entity3 had low overall survival outcomes. Advanced age, stage, and @entity1 are the main factors affecting prognosis. Treatment planning should consider high-risk factors to improve survival outcome.

title: Survival Outcome of @entity2 Arising from Sinonasal XXXX .

answer: @entity3


abstract: BACKGROUND: @entity2 repair (EVAR) is one of the first-line therapies of @entity3 . @entity1 is the most common complication of EVAR. Computed tomography angiography (CTA), which is routine for follow-up, has side effects (e.g., radiation) and also has a certain percentage of missed diagnosis. Preliminary studies on contrast-enhanced ultrasound (CEUS) have shown that the sensitivity of CEUS for detecting @entity4 is no lower than that of CTA. To investigate the advantages of CEUS, we conducted CEUS examinations of post-EVAR cases in which CTA failed to detect @entity4 or could not verify the type of @entity4 . METHODS: Post-EVAR @entity0 , who were clinically considered to have @entity4 and met the inclusion criteria were enrolled between March 2013 and November 2014. All of the @entity0 underwent @entity5 ( @entity5 ) and a CEUS examination. Size, location, microbubble dispersion, and hemodynamic characteristics of leaks were recorded. Comparison between the diagnosis of CEUS and @entity5 was conducted using Fisher's exact test and clinical outcomes of all @entity0 were followed up. RESULTS: Sixteen @entity0 were enrolled, and 12 (75%) had endoleaks with verified types by CEUS. Among 12 cases of endoleaks were positive by CEUS, 10 were @entity5 -positive, and the four CEUS-negative cases were all negative by @entity5 . The diagnostic values of CEUS and @entity5 were statistically different (P = 0.008). Six @entity0 with high-pressure endoleaks received endovascular re-intervention guided by CEUS results. One @entity0 with @entity4 had open surgery when endovascular repair failed. CONCLUSIONS: CEUS is a new, safe, and effective means for detection of endoleaks post-EVAR. This technique can be used as a supplement for routine CTA follow-up to provide more detailed information on @entity4 and its category.

title: Contrast-enhanced Ultrasound in Detecting Endoleaks with Failed Computed Tomography Angiography Diagnosis after XXXX Repair.

answer: @entity3


abstract: BACKGROUND: The management of 1- to 2-cm appendiceal @entity1 remains controversial. Here we use the National Cancer Data Base (NCDB) to compare long-term outcomes for @entity0 treated via resection of the @entity1 alone vs @entity2 ( @entity2 ). STUDY DESIGN: The 1998 to 2011 NCDB User File was queried to identify @entity0 with 1- to 2-cm appendiceal @entity3 . @entity0 were stratified by surgical technique: resection of the @entity1 alone vs @entity2 with regional lymphadenectomy. Multivariable logistic regression was used to compare short-term outcomes. Survival was estimated using the Kaplan-Meier method with comparisons based on the log-rank test. RESULTS: A total of 916 @entity0 were identified, including 42% managed with primary resection and 58% with @entity2 . @entity0 who underwent @entity2 had slightly larger @entity1 and @entity1 ; otherwise, there were no baseline differences between groups. The rates of positive margins were similar (5.5% vs 4.5%; p  = 0.60). Among all @entity0 , 1- and 5-year survival were 98.1% and 88.7% vs 96.7% and 87.4% (p  = 0.52) for those managed via primary resection vs @entity2 , respectively. Among @entity0 with moderate/high-grade/anaplastic @entity3 , 1- and 5-year survival were 93.3% and 72.0% vs 92.3% and 71.9%, respectively (p  = 0.78). After adjustment with Cox proportional hazards modeling, we confirmed that there was no survival benefit for @entity0 undergoing @entity2 (hazard ratio  = 1.14; p  = 0.72). CONCLUSIONS: For 1- to 2-cm appendiceal @entity3 , formal resection of the right colon does not appear to improve survival, even for higher-grade @entity1 . Our findings suggest that resection of the @entity1 alone is adequate for all @entity3 <2 cm.

title: Management of 1- to 2-cm XXXX of the Appendix: Using the National Cancer Data Base to Address Controversies in General Surgery.

answer: @entity1


abstract: OBJECTIVE: Imaging with fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) has, until recently provided disappointing results with low sensitivity ranging from 31%-64% in @entity0 with well-differentiated @entity2 ( @entity2 ) at all prostatic specific antigen (PSA) levels while fluorine-18-fluoroethylcholine ((18)F- @entity4 ) PET/CT showed about 85% sensitivity in restaging @entity0 after relapse. We present our experience of the sensitivity of (18)F- @entity4 PET/CT in the early stages of @entity2 . SUBJECT AND METHODS: Fifty @entity0 were prospectively recruited and imaged, of which 40 fulfilled all inclusion criteria. Our @entity0 had an average age of 65.5 years. Fifteen @entity0 were referred for initial staging, with the remaining 25 referred for restaging and all @entity0 had histologically confirmed @entity3 . @entity0 were imaged by (18)F- @entity4 PET/CT. Findings were evaluated qualitatively and quantitatively and compared to the results of histology, PSA, Gleason score and bone scintigraphy. The prostate SUVmax was also used. RESULTS: Thirty-one @entity0 demonstrated abnormal pelvic- and or extra- pelvic findings on (18)F- @entity4 PET/CT, which was consistent with malignant or metastatic involvement. The prostate SUVmax could not be used to predict the presence or absence of @entity1 . CONCLUSION: Findings of this paper suggest that (18)F- @entity4 PET/CT in 30/40 cases (estimated as 75%) was helpful in the initial staging, restaging and lymph node detection of @entity0 with @entity2 . The SUVmax was not helpful. We diagnosed more @entity2 cases in our African-American @entity0 as compared to the Caucasian @entity0 .

title: Fluorine-18-Fluoroethylcholine PET/CT in the detection of XXXX : A South African experience.

answer: @entity2


abstract: In a randomized, double-blind, Phase III study, we compared @entity9 long-acting release ( @entity9 LAR) with @entity7 long-acting repeatable ( @entity7 LAR) in managing @entity3 refractory to first-generation @entity6 analogues. Adults with @entity1 of the digestive tract were randomly assigned (1:1) to receive @entity9 LAR (60 mg) or @entity7 LAR (40 mg) every 28 days. Primary outcome was symptom control based on frequency of bowel movements and @entity5 episodes. Objective @entity1 response was a secondary outcome. Progression-free survival (PFS) was calculated in a post hoc analysis. Adverse events were recorded. At the time of a planned interim analysis, the data monitoring committee recommended halting the study because of a low predictive probability of showing superiority of @entity9 over @entity7 for symptom control (n=43 @entity9 LAR, 20.9%; n=45 @entity7 LAR, 26.7%; odds ratio, 0.73; 95% confidence interval [CI], 0.27-1.97; P=0.53). Tumor control rate at month 6 was 62.7% with @entity9 and 46.2% with @entity7 (odds ratio, 1.96; 95% CI, 0.89-4.32; P=0.09). Median (95% CI) PFS was 11.8 months (11.0 - not reached) with @entity9 versus 6.8 months (5.6 - not reached) with @entity7 (hazard ratio, 0.46; 95% CI, 0.20-0.98; P=0.045). The most frequent drug-related adverse events ( @entity9 vs @entity7 ) included @entity8 (28.3% vs 5.3%), @entity4 (11.3% vs 3.5%), and @entity2 (9.4% vs 0%). We conclude that, among @entity0 with @entity3 refractory to available @entity6 analogues, similar proportions of @entity0 receiving @entity9 LAR or @entity7 LAR achieved symptom control at month 6. @entity9 LAR showed a trend toward higher @entity1 control rate at month 6, although it was statistically not significant, and was associated with a longer PFS than @entity7 LAR.

title: Phase III study of @entity9 long-acting release in @entity0 with metastatic @entity1 and XXXX refractory to available @entity6 analogues.

answer: @entity3