abstract: BACKGROUND _ AIMS: The aim of this study was to systematically assess the diagnostic and prognostic value of early liver biopsy in @entity0 who require hospital admission with @entity5 of @entity8 . METHODS: Sixty-eight @entity0 with @entity5 of @entity8 underwent a liver biopsy within 7 days and the biopsies were processed using routine stains and K8/18 immunohistochemistry to characterize @entity4 . The biopsies were scored by two independent histopathologists using pre-defined criteria. The @entity0 were managed according to institutional protocols and followed until the time of hospital discharge or @entity2 . RESULTS: With use of K8/18 immunohistochemistry, very high concordance rate for the diagnosis of @entity4 was reached (r = 0.7; p = 0.0001). The presence of a @entity7 ( @entity7 ) suggestive of @entity9 ( @entity9 ), predicts severe @entity9 histologically in only 50% @entity0 . Moreover, in 41% of @entity7 negative @entity0 who were thought not to have @entity9 , a diagnosis of @entity9 was subsequently confirmed on histological grading. @entity0 that have @entity7 criteria but no evidence of histological @entity9 are more likely to develop @entity3 which may be indicated by the severity of canalicular @entity6 . Nineteen @entity0 died during follow up. @entity0 manifesting @entity9 on biopsy who were also @entity7 positive, had a significantly greater risk of mortality compared to those that were @entity7 positive but @entity9 negative (p < 0.01) and those that were @entity7 negative (p < 0.0001). CONCLUSIONS: The use of K8/18 immunostaining allows grading of the severity of @entity9 . Early liver biopsy in these @entity0 presenting with @entity5 of @entity1 is safe and provides important diagnostic and prognostic information.

title: The role of liver biopsy in the diagnosis and prognosis of @entity0 with XXXX of @entity8 .

answer: @entity5


abstract: BACKGROUND _ AIMS: The aim of this study was to systematically assess the diagnostic and prognostic value of early liver biopsy in @entity0 who require hospital admission with @entity5 of @entity8 . METHODS: Sixty-eight @entity0 with @entity5 of @entity8 underwent a liver biopsy within 7 days and the biopsies were processed using routine stains and K8/18 immunohistochemistry to characterize @entity4 . The biopsies were scored by two independent histopathologists using pre-defined criteria. The @entity0 were managed according to institutional protocols and followed until the time of hospital discharge or @entity2 . RESULTS: With use of K8/18 immunohistochemistry, very high concordance rate for the diagnosis of @entity4 was reached (r = 0.7; p = 0.0001). The presence of a @entity7 ( @entity7 ) suggestive of @entity9 ( @entity9 ), predicts severe @entity9 histologically in only 50% @entity0 . Moreover, in 41% of @entity7 negative @entity0 who were thought not to have @entity9 , a diagnosis of @entity9 was subsequently confirmed on histological grading. @entity0 that have @entity7 criteria but no evidence of histological @entity9 are more likely to develop @entity3 which may be indicated by the severity of canalicular @entity6 . Nineteen @entity0 died during follow up. @entity0 manifesting @entity9 on biopsy who were also @entity7 positive, had a significantly greater risk of mortality compared to those that were @entity7 positive but @entity9 negative (p < 0.01) and those that were @entity7 negative (p < 0.0001). CONCLUSIONS: The use of K8/18 immunostaining allows grading of the severity of @entity9 . Early liver biopsy in these @entity0 presenting with @entity5 of @entity1 is safe and provides important diagnostic and prognostic information.

title: The role of liver biopsy in the diagnosis and prognosis of @entity0 with @entity5 of XXXX .

answer: @entity8


abstract: BACKGROUND _ AIMS: The aim of this study was to systematically assess the diagnostic and prognostic value of early liver biopsy in @entity0 who require hospital admission with @entity5 of @entity8 . METHODS: Sixty-eight @entity0 with @entity5 of @entity8 underwent a liver biopsy within 7 days and the biopsies were processed using routine stains and K8/18 immunohistochemistry to characterize @entity4 . The biopsies were scored by two independent histopathologists using pre-defined criteria. The @entity0 were managed according to institutional protocols and followed until the time of hospital discharge or @entity2 . RESULTS: With use of K8/18 immunohistochemistry, very high concordance rate for the diagnosis of @entity4 was reached (r = 0.7; p = 0.0001). The presence of a @entity7 ( @entity7 ) suggestive of @entity9 ( @entity9 ), predicts severe @entity9 histologically in only 50% @entity0 . Moreover, in 41% of @entity7 negative @entity0 who were thought not to have @entity9 , a diagnosis of @entity9 was subsequently confirmed on histological grading. @entity0 that have @entity7 criteria but no evidence of histological @entity9 are more likely to develop @entity3 which may be indicated by the severity of canalicular @entity6 . Nineteen @entity0 died during follow up. @entity0 manifesting @entity9 on biopsy who were also @entity7 positive, had a significantly greater risk of mortality compared to those that were @entity7 positive but @entity9 negative (p < 0.01) and those that were @entity7 negative (p < 0.0001). CONCLUSIONS: The use of K8/18 immunostaining allows grading of the severity of @entity9 . Early liver biopsy in these @entity0 presenting with @entity5 of @entity1 is safe and provides important diagnostic and prognostic information.

title: The role of liver biopsy in the diagnosis and prognosis of XXXX with @entity5 of @entity8 .

answer: @entity0


abstract: UNASSIGNED: Epistasis is a key factor in evolution since it determines which combinations of mutations provide adaptive solutions and which mutational pathways toward these solutions are accessible by natural selection. There is growing evidence for the pervasiveness of sign epistasis-a complete reversion of mutational effects, particularly in protein evolution-yet its molecular basis remains poorly understood. We describe the structural basis of sign epistasis between @entity3 and @entity4 , two adaptive mutations in @entity2 b-lactamase- an enzyme that endows antibiotics resistance. Separated by 10  , these mutations initiate two separate trajectories toward increased hydrolysis rates and resistance toward second and third-generation cephalosporins antibiotics. Both mutations allow the enzyme's active site to adopt alternative conformations and accommodate the new antibiotics. By solving the corresponding set of crystal structures, we found that @entity4 causes @entity0 whereas @entity3 induces discrete conformations. When combined, the mutations in 238 and 164 induce @entity0 whereby nonproductive conformations that perturb the enzyme's catalytic preorganization dominate. Specifically, @entity1 170 that coordinates the deacylating water molecule is misaligned, in both the free form and the inhibitor-bound double mutant. This @entity0 is not restored by stabilizing global suppressor mutations and thus leads to an evolutionary cul-de-sac. Conformational dynamism therefore underlines the reshaping potential of protein's structures and functions but also limits protein evolvability because of the fragility of the interactions networks that maintain protein structures.

title: Negative Epistasis and Evolvability in XXXX b-Lactamase-The Thin Line between an Enzyme's Conformational Freedom and Disorder.

answer: @entity2


abstract: BACKGROUND: Although many comprehensive batteries exist to evaluate the nature and degree of @entity1 in @entity0 with @entity3 , short batteries hold promise for rapidly screening and estimating @entity1 . Recently, the Brief Neurocognitive Assessment (BNA) was established and has been shown to have similar validity and utility to a more comprehensive battery of cognitive tests in evaluating global @entity1 in @entity0 with @entity3 . The present study sought to further establish the validity of the BNA by comparing it with the MATRICS Consensus Cognitive Battery (MCCB). METHODS: One-hundred seventy-six @entity0 with @entity3 and 300 healthy volunteers participated in the present study. Global cognition was evaluated using the MCCB composite score and estimated using the BNA. To examine practice effects and test-retest reliability, @entity0 were re-assessed after 4weeks. RESULTS: The BNA was highly correlated with global cognition as evaluated by the MCCB in both the @entity3 (r=0.82) and healthy control samples (r=0.75). Both instruments were similarly sensitive to @entity1 in @entity0 with @entity3 relative to healthy controls. The BNA also demonstrated high test-retest reliability in @entity0 with @entity3 (r=0.87), comparable to the level observed with the MCCB (r=0.91). In addition, both the BNA and MCCB showed a similar level of practice effects (both Cohen's d=0.11), and both instruments demonstrated equivalent sensitivities to longitudinal change. Furthermore, scores from the BNA and MCCB were related to symptom severity and functional capacity to a similar degree. CONCLUSIONS: The BNA provides clinicians and researchers with an efficient and reliable means by which to evaluate global @entity2 in @entity0 with @entity3 by allowing estimation of performance on a more comprehensive standardized battery.

title: Examination of the validity of the Brief Neurocognitive Assessment (BNA) for XXXX .

answer: @entity3


abstract: BACKGROUND: @entity1 is an important health problem, due to the increasing number of new cases and the quality of life issues brought forth by surgical treatment in these @entity0 . AIM: The aim of the study was to analyse the results of robotic surgery in the treatment of lower and middle @entity1 ,locations in which @entity4 is performed. MATERIAL AND METHOD: @entity0 diagnosed with and operated on for @entity1 by the means of robotic surgery between 2008-2012 at the Fundeni Clinical Institute were retrospectively analysed. RESULTS: A number of 117 @entity0 with @entity1 were operated on by robotic surgery, of which 79 (67.52%) were submitted to @entity4 ( @entity4 ). The most frequently performed surgery was low anterior resection, followed by rectal amputation through abdominoperineal approach. @entity2 @entity3 was observed in 9 (11.39%) @entity0 . Local recurrence was encountered in 2 (2.53%) of the robotically performed surgeries. CONCLUSIONS: 1. Robotically assisted @entity4 is feasible, safe and can be performed with a small number of complications and a low local recurrence rate; 2. The main advantages are oncological safety and quality of life; 3.Conversion to open surgery is rarely encountered; 4. Protection loop ileostomy existence allows avoiding reintervention in case anastomotic @entity3 occurs in @entity0 with low anterior resection. 5. Robotic surgery may become gold standard in the surgical treatment of @entity1 .

title: Robotically performed XXXX for @entity1 .

answer: @entity4


abstract: BACKGROUND: @entity1 is an important health problem, due to the increasing number of new cases and the quality of life issues brought forth by surgical treatment in these @entity0 . AIM: The aim of the study was to analyse the results of robotic surgery in the treatment of lower and middle @entity1 ,locations in which @entity4 is performed. MATERIAL AND METHOD: @entity0 diagnosed with and operated on for @entity1 by the means of robotic surgery between 2008-2012 at the Fundeni Clinical Institute were retrospectively analysed. RESULTS: A number of 117 @entity0 with @entity1 were operated on by robotic surgery, of which 79 (67.52%) were submitted to @entity4 ( @entity4 ). The most frequently performed surgery was low anterior resection, followed by rectal amputation through abdominoperineal approach. @entity2 @entity3 was observed in 9 (11.39%) @entity0 . Local recurrence was encountered in 2 (2.53%) of the robotically performed surgeries. CONCLUSIONS: 1. Robotically assisted @entity4 is feasible, safe and can be performed with a small number of complications and a low local recurrence rate; 2. The main advantages are oncological safety and quality of life; 3.Conversion to open surgery is rarely encountered; 4. Protection loop ileostomy existence allows avoiding reintervention in case anastomotic @entity3 occurs in @entity0 with low anterior resection. 5. Robotic surgery may become gold standard in the surgical treatment of @entity1 .

title: Robotically performed @entity4 for XXXX .

answer: @entity1


abstract: INTRODUCTION: The laparoscopic-assisted abdominoperineal resection (LAPR) has been proved to be associated with a shorter postoperative recovery, with equivalent oncological results and similar survival when compared with conventional open surgery, for @entity0 with @entity1 . METHOD: Case report of a massive @entity4 during LAPR and systematic review of the English language literature, using PubMed Medline, ISI Thopmson, OVID and EMBASE databases. RESULTS: 58 years old @entity0 admitted in emergency setting or @entity3 . Rectal examination revealed a protruding,frail @entity1 , located 2 cm from the anal verge. Total colono scopy revealed an infiltrative, protruding @entity1 , situated at 2 cm from the anal verge, with a 5 cm cranial extension,without any additional @entity5 . Computed Tomography showed a 4,5 cm circumferential rectal wall thickening, without any enlarged mesorectal or abdominal lymph nodes. The @entity0 was transported to operating room for a LAPR. During final hemostasis, at the level of perineal surgical wound, an acute massive @entity3 occurred from the presacral vessels with severe @entity2 . This @entity3 couldnot be managed laparo scopicaly and conversion to laparotomywas decided, with pelvic packing. At 48 hours after the initial surgical approach, the tamponing packs were removed, without signs of active @entity3 . There were applied haemostatic agents and the perineal wound was sutured, without further rbleeding during in-hospital stay. CONCLUSIONS: A rapid and effective control of the @entity3 is mandatory to prevent a fatal outcome. Pelvic packing remains a life-saving procedure and the treatment of choice in severe cases.

title: Massive XXXX after laparoscopic assisted abdominoperineal resection: a case report and systematic review of the literature.

answer: @entity4


abstract: AIM: The potential psycho-social sequelae of traumatic @entity6 have received increasing attention in recent years, however there remains paucity of cross-national comparative data on the prevalence of @entity4 following such @entity1 . The aim of the present study was to investigate and compare the prevalence of @entity2 and @entity3 in an adult @entity0 group who have been treated for maxillofacial @entity1 , and who attend a follow-up clinic in either the West Midlands, UK or New South Wales (NSW), Australia. By using an identical methodological and statistical approach, we hoped to add to the available information on the incidence of early @entity4 in @entity0 following facial @entity1 . METHOD: This was a comparative cross-sectional study. A sample of fifty consecutive adult victims of facial @entity1 in the West Midlands UK, was compared to a group of fifty-two facially injured @entity0 in NSW, Australia. Demographic data was collected, following which the @entity3 and @entity2 Scale (HADS) were applied to both groups of @entity0 . RESULTS: Psychometric scores suggestive of @entity2 and @entity3 state were common in both groups of @entity0 . The mean HADS @entity3 subscale score for UK @entity0 compared to Australian @entity0 was not significantly different (5.94 versus 5.54 p=0.62). This was also the case for the HADS @entity2 subscale (5.96 versus 5.94 p=0.98). Although the number of @entity0 achieving scores suggestive of a 'caseness' for co-morbid psychological state was higher within the UK sample when compared to the Australian group (20% versus 11.5% for HADS @entity3 subscale, and 20% versus 15% for HADS @entity2 subscales respectively); these differences did not reach statistical significance. CONCLUSION: This cross-national comparative study has shown that @entity2 and @entity3 in @entity5 were comparable in both settings.

title: The prevalence of XXXX in a sample of @entity5 . A comparative cross-sectional study between UK and Australia.

answer: @entity4


abstract: AIM: The potential psycho-social sequelae of traumatic @entity6 have received increasing attention in recent years, however there remains paucity of cross-national comparative data on the prevalence of @entity4 following such @entity1 . The aim of the present study was to investigate and compare the prevalence of @entity2 and @entity3 in an adult @entity0 group who have been treated for maxillofacial @entity1 , and who attend a follow-up clinic in either the West Midlands, UK or New South Wales (NSW), Australia. By using an identical methodological and statistical approach, we hoped to add to the available information on the incidence of early @entity4 in @entity0 following facial @entity1 . METHOD: This was a comparative cross-sectional study. A sample of fifty consecutive adult victims of facial @entity1 in the West Midlands UK, was compared to a group of fifty-two facially injured @entity0 in NSW, Australia. Demographic data was collected, following which the @entity3 and @entity2 Scale (HADS) were applied to both groups of @entity0 . RESULTS: Psychometric scores suggestive of @entity2 and @entity3 state were common in both groups of @entity0 . The mean HADS @entity3 subscale score for UK @entity0 compared to Australian @entity0 was not significantly different (5.94 versus 5.54 p=0.62). This was also the case for the HADS @entity2 subscale (5.96 versus 5.94 p=0.98). Although the number of @entity0 achieving scores suggestive of a 'caseness' for co-morbid psychological state was higher within the UK sample when compared to the Australian group (20% versus 11.5% for HADS @entity3 subscale, and 20% versus 15% for HADS @entity2 subscales respectively); these differences did not reach statistical significance. CONCLUSION: This cross-national comparative study has shown that @entity2 and @entity3 in @entity5 were comparable in both settings.

title: The prevalence of @entity4 in a sample of XXXX . A comparative cross-sectional study between UK and Australia.

answer: @entity5


abstract: @entity2 surgery plays a pivotal role in the successful treatments of @entity2 . In China, economic burden for @entity2 @entity0 is heavy. Because of limited economic resources, appropriate utilization of presurgical evaluation technologies is especially important for @entity1 @entity0 , who could benefit from surgery. This study proposed the strategies for restricting the cost of presurgical evaluation for resective surgery in @entity1 population with @entity2 . A retrospective study was performed on the database of @entity0 with resective surgery from January 2007 to June 2009 in West China Hospital of Sichuan University. Presurgical evaluation technologies and outcome were analyzed. As a result, 143 @entity0 underwent resective operation were included in this study. @entity3 free can be reached at 63.8% @entity0 with (ATL) and 61.1% with focal lesionectomy (FLE). Magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), routine electroencephalography (REEG), video-EEG (VEEG) and invasive-EEG (IEEG) were used for investigation. The cost of those technologies was listed for consultation. Based on these findings, how to make the proper choice for surgery candidates was suggested according to different types of @entity2 .

title: How to effectively constrain the cost of presurgical evaluation for resective surgery in XXXX population: clinically oriented opinions.

answer: @entity1


abstract: The @entity0 middle midgut cells derived from the endoderm develop into four distinct types of cell. Of these cells, @entity1 cells have invaginated microvillar membranes on their apical surface, and they are involved in two distinct functions, i.e., @entity1 absorption and acid secretion. The homeobox gene @entity2 proventriculus (dve) is expressed in the midgut, and two transcripts, type A (   4.9kb) and type B (   3.5kb), have been identified. We isolated the deletion allele dve(E181) that completely removes the first exon for type-A (dve-A) transcript. Dve expression pattern in dve-A mutant background indicates that isoform switching is dynamically regulated in a cell-type specific manner. Using RNAi for dve-A, we examined spatial and temporal requirement of the Dve-A activity. Early Dve-A activity is required to repress isoform switching in @entity1 cells, and for establishment of two gut functions. Late Dve-A activity in @entity1 cells, but not in adjacent interstitial cells, is required for acid secretion, while the activity is redundantly required in both cells for the @entity1 absorptive function. Furthermore, ectopic type-B expression in larval @entity1 cells specifically impaired the @entity1 absorptive function. These results provide insight into molecular mechanisms to establish functional specificity.

title: Spatial and temporal requirement of @entity2 proventriculus activity during XXXX midgut development.

answer: @entity0


abstract: The @entity0 middle midgut cells derived from the endoderm develop into four distinct types of cell. Of these cells, @entity1 cells have invaginated microvillar membranes on their apical surface, and they are involved in two distinct functions, i.e., @entity1 absorption and acid secretion. The homeobox gene @entity2 proventriculus (dve) is expressed in the midgut, and two transcripts, type A (   4.9kb) and type B (   3.5kb), have been identified. We isolated the deletion allele dve(E181) that completely removes the first exon for type-A (dve-A) transcript. Dve expression pattern in dve-A mutant background indicates that isoform switching is dynamically regulated in a cell-type specific manner. Using RNAi for dve-A, we examined spatial and temporal requirement of the Dve-A activity. Early Dve-A activity is required to repress isoform switching in @entity1 cells, and for establishment of two gut functions. Late Dve-A activity in @entity1 cells, but not in adjacent interstitial cells, is required for acid secretion, while the activity is redundantly required in both cells for the @entity1 absorptive function. Furthermore, ectopic type-B expression in larval @entity1 cells specifically impaired the @entity1 absorptive function. These results provide insight into molecular mechanisms to establish functional specificity.

title: Spatial and temporal requirement of XXXX proventriculus activity during @entity0 midgut development.

answer: @entity2


abstract: BACKGROUND: Following @entity3 , individual @entity0 can have wide variations in the extent of @entity7 ( @entity7 ) and increased left ventricular (LV) mass. Both affect the risk for @entity9 , but only LV ejection fraction is used for risk prediction. OBJECTIVE: The purpose of this study was to evaluate the independent as well as the additive contributions of increased LV mass and decreased LV ejection fraction to @entity9 in the general population. METHODS: In the ongoing Oregon Sudden Unexpected Death Study, we studied consecutive @entity9 cases (n = 191) and @entity2 controls (n = 203) from the Portland, Oregon, metropolitan area (population approximately 1,000,000; 2002-2008). Comparisons of echocardiographic LV mass obtained prior and unrelated to @entity9 ( @entity9 ) were conducted, and a logistic regression model was used to evaluate the relationship between @entity9 , severe @entity7 , LV mass, and other relevant clinical variables. RESULTS: In a multivariate model, both severe @entity7 and @entity10 ( @entity10 ) were associated with increased @entity9 risk (odds ratio [OR] 1.9, 95% confidence interval [CI] 1.1-3.2 for severe @entity7 ; OR 1.8, 95% CI 1.1-2.9 for @entity10 ). In @entity0 with coexisting severe @entity7 and @entity10 , risk of @entity9 was additive (OR 3.5, 95% CI 1.7-7.2). In the same model, increased age, @entity6 /flutter, elevated @entity8 , and @entity1 independently increased risk, and use of angiotensin receptor blockers attenuated risk. CONCLUSION: Reduced LV ejection fraction and increased LV mass had independent and additive effects on risk of @entity5 . Despite the significant overlap between the two conditions, these findings point toward the existence of independent mechanistic pathways for @entity4 that occur due to @entity7 and @entity10 .

title: Increased left ventricular mass and decreased left ventricular systolic function have independent pathways to ventricular arrhythmogenesis in XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity1 is a rare injury which, if missed, leads to delayed surgical treatment and may result in the loss of the knee joint function. The aim of this study was to report our results of operative treatment of the @entity1 and point out the significance of timely diagnosis and surgical procedure. MATERIAL AND METHODS: This retrospective ten-year study included 20 @entity0 , 15 males and 5 females, their mean age being 42 (20-84) years. Seven @entity0 had an injury on the right side and 13 had an injury on the left side. Thirteen @entity0 had the diagnosis set in the first seven days after the injury. The applied techniques were surgical suture of the tendon, bone-tendon-bone ligamentoplasty using allograft from a bone bank and bone-tendon-bone ligamentoplasty using contralateral autograft, and they were performed in 12, 5 and 3 @entity0 , respectively. The treatment results were assessed by using the Lysholm score, measuring the range of movement in the knee joint and measuring the girth of the thigh 10 cm above the patella. RESULTS: The follow-up period after the surgery was 4 years on average (1-10 years) and the average value of the Lysholm score was 83 (27-100). The result was found to be excellent in 11 cases, satisfactory in 5 cases and unsatisfactory in 4. A statistically significant difference (p=0.0197 p<0.05) was found in the average values of the Lysholm score between the group of @entity0 with risk factors (71.78) and the subjects without risk factors (92.18). A statistically significant difference (p=0.008 p<0.01) was found in the Lysholm score between the @entity0 with timely diagnosis (91.62) and cases of chronic tendon tear (67). CONCLUSION: Timely diagnosis and early surgical reparation are the basic imperatives in the treatment of this injury. Comorbidity and risk factors are related to a poorer postoperative Lysholm score. The method of choice is early surgical treatment.

title: XXXX --treatment results.

answer: @entity1


abstract: Novel magnetic molecularly imprinted polymer (MIP) beads using @entity4 as template for use in extraction was developed by microwave heating initiated suspension polymerization. Microwave heating, as an alternative heating source, significantly accelerate the polymerization process. By incorporating magnetic @entity1 , superparamagnetic composite MIP beads with average diameter of 80  m were obtained. The imprinted beads were then characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and vibrating sample magnetometer. Highly cross-linked porous surface and good magnetic property were observed. The adsorption isotherm modeling was performed by fitting the data to Freundlich isotherm model. The binding sites measured were 3.24  mol g(-1) and 1.17  mol g(-1) for the magnetic MIP beads and the corresponding non-imprinted magnetic beads, respectively. Cross-selectivity experiments showed the recognition ability of the magnetic MIP beads to analytes is relative to degree of molecular analogy to the template. Finally, this magnetic MIP bead was successfully used for enrichment of @entity4 , @entity3 and @entity2 from ultrasonically extracted solution of pork and @entity0 liver followed by high performance chromatography with fluorescence detection. The proposed method presented good linearity and the detection limits was 0.52-1.04 ng mL(-1).The recoveries were from 82.0% to 90.0% and from 80.4% to 86.8% for the spiked pork and @entity0 liver, respectively, with the RSDs of 5.8-10.0%. Combination of the specific adsorption property of the MIP material and the magnetic separation provided a powerful analytical tool of simplicity, flexibility, and selectivity.

title: Magnetic molecularly imprinted polymer beads prepared by microwave heating for selective enrichment of b-agonists in pork and XXXX liver samples.

answer: @entity0


abstract: @entity2 ( @entity2 ) are uncommon @entity1 which are usually benign. Our interest was aroused by encountering @entity0 with reportedly benign @entity2 which later, after surgery, recurred as @entity1 . We conducted a retrospective study of 17 @entity0 treated for benign @entity2 during a period of 9 years. Of these @entity0 , 4 developed malignant recurrence (3 females and 1 male) with a mean age of 19 months. The average time to recurrence was 17 months. Recurrence presented as a gluteal mass in one case, urinary and digestive compression signs in another case and as elevated @entity3 levels in the two remaining cases. Histologically, one of the original @entity1 included tiny immature foci but none contained a malignant component after reading slides. Recurrences were as @entity1 in all cases. After surgery and adjuvant chemotherapy, only one @entity0 died from complications related to chemotherapy. The other three were alive and well at mean follow-up of 5 years. These results emphasise the need for close clinical and biological follow-up for at least 2 years in all @entity0 who had undergone excision of a neonatal @entity2 .

title: [Malignant recurrence of "mature" XXXX . A clinicopathological study of 4 cases].

answer: @entity2


abstract: OBJECTIVE: To evaluate the efficacy and effectiveness of @entity4 on 3rd degree haemorrhoids. METHODS: Study was done at Surgical Unit, Civil Hospital Karachi, during a period of 19 months from December 2006 to July 2008. Out of 344 @entity0 80 @entity0 were included in the study with 3rd degree internal haemorrhoids and were treated with Rubber band ligation (RBL). Outcome data was recorded for success of treatment. RESULT: Among 80 @entity0 , 77 (96.25%) were symptom free. After completion of treatment, 1 (16.66%) out of 5 @entity0 had the complaint of @entity1 , 2 (2.85%) out of 70 had complaints of @entity3 . Before start of treatment 5 (6.25%) @entity0 complained of @entity2 per rectum and 73 (91.25%) complained of manually reducible/prolapsed haemorrhoids. Both complaints were cured 100% after treatment. CONCLUSION: RBL is an efficient, cost-effective and simple out @entity0 procedure for symptomatic @entity5 with minimum complications. RBL is a reliable, safe procedure requiring no hospitalization and no use of any anaesthetic drugs.

title: A prospective study of outcome from @entity4 in XXXX .

answer: @entity5


abstract: OBJECTIVE: To evaluate the efficacy and effectiveness of @entity4 on 3rd degree haemorrhoids. METHODS: Study was done at Surgical Unit, Civil Hospital Karachi, during a period of 19 months from December 2006 to July 2008. Out of 344 @entity0 80 @entity0 were included in the study with 3rd degree internal haemorrhoids and were treated with Rubber band ligation (RBL). Outcome data was recorded for success of treatment. RESULT: Among 80 @entity0 , 77 (96.25%) were symptom free. After completion of treatment, 1 (16.66%) out of 5 @entity0 had the complaint of @entity1 , 2 (2.85%) out of 70 had complaints of @entity3 . Before start of treatment 5 (6.25%) @entity0 complained of @entity2 per rectum and 73 (91.25%) complained of manually reducible/prolapsed haemorrhoids. Both complaints were cured 100% after treatment. CONCLUSION: RBL is an efficient, cost-effective and simple out @entity0 procedure for symptomatic @entity5 with minimum complications. RBL is a reliable, safe procedure requiring no hospitalization and no use of any anaesthetic drugs.

title: A prospective study of outcome from XXXX in @entity5 .

answer: @entity4


abstract: @entity4 ( @entity4 ) is an early step in the process of @entity1 metastasis. It is well known that @entity1 microenvironment affects @entity3 ; in particular, that @entity5 induces @entity4 . Deregulated notch signaling also contributes a lot to the development of @entity0 . In this study, we investigated the use of @entity2 -inhibiting compound as novel therapeutic candidates to regulate @entity5 -induced @entity0 cells. According to previous screening, @entity14 was selected as a @entity2 inhibitor. @entity5 -induced @entity4 was characteristic of increased @entity10 _ @entity7 expressions and decreased @entity9 expressions. Treatment with @entity14 notably attenuated @entity5 -induced @entity4 , invasion and migration in H1299 cells, accompanied with reduced @entity2 , @entity16 expressions and its downstream genes @entity12 and @entity6 . @entity14 treatment also promoted tumorsuppressive @entity13 level. Moreover, @entity2 siRNA prevented @entity5 -mediated cell migration and decreased @entity11 , @entity8 , and @entity15 expressions, which are key @entity4 markers. Re-expression of @entity13 blocked @entity5 -induced @entity4 and cell invasion. Our findings suggest that downregulation of @entity2 and reexpression of @entity13 by @entity14 might be a novel remedy for the therapy of @entity0 .

title: XXXX inhibited @entity5 -induced epithelial-mesenchymal transition of @entity0 cells by inactivating of @entity2 signaling and switching on @entity13 .

answer: @entity14


abstract: @entity4 ( @entity4 ) is an early step in the process of @entity1 metastasis. It is well known that @entity1 microenvironment affects @entity3 ; in particular, that @entity5 induces @entity4 . Deregulated notch signaling also contributes a lot to the development of @entity0 . In this study, we investigated the use of @entity2 -inhibiting compound as novel therapeutic candidates to regulate @entity5 -induced @entity0 cells. According to previous screening, @entity14 was selected as a @entity2 inhibitor. @entity5 -induced @entity4 was characteristic of increased @entity10 _ @entity7 expressions and decreased @entity9 expressions. Treatment with @entity14 notably attenuated @entity5 -induced @entity4 , invasion and migration in H1299 cells, accompanied with reduced @entity2 , @entity16 expressions and its downstream genes @entity12 and @entity6 . @entity14 treatment also promoted tumorsuppressive @entity13 level. Moreover, @entity2 siRNA prevented @entity5 -mediated cell migration and decreased @entity11 , @entity8 , and @entity15 expressions, which are key @entity4 markers. Re-expression of @entity13 blocked @entity5 -induced @entity4 and cell invasion. Our findings suggest that downregulation of @entity2 and reexpression of @entity13 by @entity14 might be a novel remedy for the therapy of @entity0 .

title: @entity14 inhibited @entity5 -induced epithelial-mesenchymal transition of XXXX cells by inactivating of @entity2 signaling and switching on @entity13 .

answer: @entity0


abstract: @entity4 ( @entity4 ) is an early step in the process of @entity1 metastasis. It is well known that @entity1 microenvironment affects @entity3 ; in particular, that @entity5 induces @entity4 . Deregulated notch signaling also contributes a lot to the development of @entity0 . In this study, we investigated the use of @entity2 -inhibiting compound as novel therapeutic candidates to regulate @entity5 -induced @entity0 cells. According to previous screening, @entity14 was selected as a @entity2 inhibitor. @entity5 -induced @entity4 was characteristic of increased @entity10 _ @entity7 expressions and decreased @entity9 expressions. Treatment with @entity14 notably attenuated @entity5 -induced @entity4 , invasion and migration in H1299 cells, accompanied with reduced @entity2 , @entity16 expressions and its downstream genes @entity12 and @entity6 . @entity14 treatment also promoted tumorsuppressive @entity13 level. Moreover, @entity2 siRNA prevented @entity5 -mediated cell migration and decreased @entity11 , @entity8 , and @entity15 expressions, which are key @entity4 markers. Re-expression of @entity13 blocked @entity5 -induced @entity4 and cell invasion. Our findings suggest that downregulation of @entity2 and reexpression of @entity13 by @entity14 might be a novel remedy for the therapy of @entity0 .

title: @entity14 inhibited @entity5 -induced epithelial-mesenchymal transition of @entity0 cells by inactivating of XXXX signaling and switching on @entity13 .

answer: @entity2


abstract: @entity4 ( @entity4 ) is an early step in the process of @entity1 metastasis. It is well known that @entity1 microenvironment affects @entity3 ; in particular, that @entity5 induces @entity4 . Deregulated notch signaling also contributes a lot to the development of @entity0 . In this study, we investigated the use of @entity2 -inhibiting compound as novel therapeutic candidates to regulate @entity5 -induced @entity0 cells. According to previous screening, @entity14 was selected as a @entity2 inhibitor. @entity5 -induced @entity4 was characteristic of increased @entity10 _ @entity7 expressions and decreased @entity9 expressions. Treatment with @entity14 notably attenuated @entity5 -induced @entity4 , invasion and migration in H1299 cells, accompanied with reduced @entity2 , @entity16 expressions and its downstream genes @entity12 and @entity6 . @entity14 treatment also promoted tumorsuppressive @entity13 level. Moreover, @entity2 siRNA prevented @entity5 -mediated cell migration and decreased @entity11 , @entity8 , and @entity15 expressions, which are key @entity4 markers. Re-expression of @entity13 blocked @entity5 -induced @entity4 and cell invasion. Our findings suggest that downregulation of @entity2 and reexpression of @entity13 by @entity14 might be a novel remedy for the therapy of @entity0 .

title: @entity14 inhibited XXXX -induced epithelial-mesenchymal transition of @entity0 cells by inactivating of @entity2 signaling and switching on @entity13 .

answer: @entity5


abstract: @entity4 ( @entity4 ) is an early step in the process of @entity1 metastasis. It is well known that @entity1 microenvironment affects @entity3 ; in particular, that @entity5 induces @entity4 . Deregulated notch signaling also contributes a lot to the development of @entity0 . In this study, we investigated the use of @entity2 -inhibiting compound as novel therapeutic candidates to regulate @entity5 -induced @entity0 cells. According to previous screening, @entity14 was selected as a @entity2 inhibitor. @entity5 -induced @entity4 was characteristic of increased @entity10 _ @entity7 expressions and decreased @entity9 expressions. Treatment with @entity14 notably attenuated @entity5 -induced @entity4 , invasion and migration in H1299 cells, accompanied with reduced @entity2 , @entity16 expressions and its downstream genes @entity12 and @entity6 . @entity14 treatment also promoted tumorsuppressive @entity13 level. Moreover, @entity2 siRNA prevented @entity5 -mediated cell migration and decreased @entity11 , @entity8 , and @entity15 expressions, which are key @entity4 markers. Re-expression of @entity13 blocked @entity5 -induced @entity4 and cell invasion. Our findings suggest that downregulation of @entity2 and reexpression of @entity13 by @entity14 might be a novel remedy for the therapy of @entity0 .

title: @entity14 inhibited @entity5 -induced epithelial-mesenchymal transition of @entity0 cells by inactivating of @entity2 signaling and switching on XXXX .

answer: @entity13


abstract: The article presents the analysis of data of "Study on Global AGEing and Adult Health, 2007-2010" ( @entity4 ) concerning subjective judging of health, prevalence of @entity1 @entity3 under different levels of arterial pressure in similar age groups. An attempt is made to evaluate spectrum of pharmaceuticals applied in treatment of @entity0 with arterial pressure in hospital at the level of oblast hospital. According official statistics of Minzdrav of Russia, in 20102 prevalence of diseases characterized by higher arterial pressure amounted to 10.5% in adult population and to 22.3% in population older than able-bodied age. At the same time, according @entity4 data, prevalence of various forms of @entity2 disease in population older than 50 years amounted to 52.8%. That is, this pathology is often missed in conditions of mass medical network. Thereafter, @entity0 receive no necessary medicinal therapy. The one or another treatment was provided to almost 94% of @entity0 with @entity2 disease diagnosed by physician. At that, among @entity0 received treatment the normal levels of both systolic and diastolic pressure were established in less than 20% of @entity0 with @entity2 . Therefore, the issue of effectiveness of applied methods of correction of arterial @entity2 become a matter of interest. The appropriate treatment of @entity2 is a mean to decrease complications and as a result to diminish mortality of diseases of circulatory system.

title: [The evaluation of medicinal therapy under treatment of arterial XXXX in hospital].

answer: @entity2


abstract: OBJECTIVE: Evaluation of the clinical effectiveness and safety of a new custom-made valgus knee brace (OdrA) in @entity4 ( @entity3 ) in terms of @entity1 and secondary symptoms. METHODS: Open-label prospective study of @entity0 with symptomatic medial knee @entity3 with clinical evaluation at 6 and 52 weeks (W6, W52). We systematically assessed @entity1 on a visual analog scale (VAS), @entity5 and @entity3 Outcome Score (KOOS), spatio-temporal gait variables, use of nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic-sparing effects of the brace and tolerance. Mean scores were compared at baseline, W6 and W52 and the effect size (ES) and 95% confidence intervals (95% CIs) were calculated. RESULTS: We included 20 @entity0 with knee @entity3 (mean age 64.2  10.2 years, mean body mass index 27.2  5.4kg/m(2)). @entity2 and KOOS were improved at W6 and W52: @entity1 (ES=0.9 at 1 year), amelioration of other symptoms (ES=0.4), and function in activities of daily living (ES=1.1), sports and leisure (ES=1.5), quality of life (ES=0.9) and gait speed (ES=0.41). In total, 76% of @entity0 showed clinical improvement at 1 year. Analgesic and NSAIDs consumption was significantly decreased at W6 and W52. One serious adverse effect noted was lower-limb varices, and observance was deemed satisfactory at 1 year. CONCLUSION: This new unloader brace appeared to have good effect on medial knee @entity3 , with an acceptable safety profile and good @entity0 compliance.

title: Clinical effectiveness and safety of a distraction-rotation knee brace for XXXX .

answer: @entity4


abstract: UNASSIGNED: Russian traditional fermented dairy foods have been consumed for thousands of years. However, little research has focused on exploiting @entity2 bacteria (LAB) resources and analyzing the LAB composition of Russian traditional fermented dairy foods. In the present study, we cultured LAB isolated from fermented mare and @entity1 milks, sour cream, and cheese collected from Kalmykiya, Buryats, and Tuva regions of Russia. Seven @entity3 species and the Bifidobacterium genus were quantified by quantitative PCR. The LAB counts in these samples ranged from 3.18 to 9.77 log cfu/mL (or per gram). In total, 599 LAB strains were obtained from these samples using de @entity0 , Rogosa, and Sharpe agar and M17 agar. The identified LAB belonged to 7 genera and 30 species by 16S rRNA and murE gene sequencing and multiplex PCR assay. The predominant LAB isolates were @entity9 (176 strains) and @entity3 (63 strains), which represented 39.9% of all isolates. The quantitative PCR results revealed that counts of 7 lactobacilli species and Bifidobacterium spp. of 30 fermented @entity1 milk samples ranged from 1.19    0.34 ( @entity9 in Tuva) to 8.09    0.71 ( @entity7 in Kalmykiya) log cfu/mL of fermented @entity1 milk (mean    standard error). The numbers of Bifidobacterium spp., Lb. plantarum, Lb. helveticus, and Lb. acidophilus revealed no significant difference between the 3 regions; nevertheless, @entity6 , @entity8 , @entity4 , and @entity5 ssp. bulgaricus exhibited different degrees of variation across 3 regions. The results demonstrate that traditional fermented dairy products from different regions of Russia have complex compositions of LAB species. The diversity of LAB might be related to the type of fermented dairy product, geographical origin, and manufacturing process.

title: Molecular identification and quantification of XXXX bacteria in traditional fermented dairy foods of Russia.

answer: @entity2


abstract: @entity8 (MK) is a heparin-binding cytokine, and promotes growth, survival, migration and other activities of target cells. After describing the general properties of MK, this review focuses on MK and MK inhibitors as therapeutics for diseases in the central nervous system. MK is strongly expressed during embryogenesis especially at the midgestation period, but is expressed only at restricted sites in adults. MK expression is induced upon tissue injury such as @entity2 . Since exogenously administered MK or the gene transfer of MK suppresses neuronal cell death in experimental systems, MK has the potential to treat @entity6 . MK might become important also in the treatment of @entity3 such as @entity4 . MK is involved in inflammatory diseases by enhancing migration of leukocytes, inducing chemokine production and suppressing regulatory T cells. Since an aptamer to MK suppresses experimental autoimmune @entity5 , MK inhibitors are promising for the treatment of @entity1 . MK is overexpressed in most @entity0 including @entity7 , and is involved in @entity0 invasion. MK inhibitors may be of value in the treatment of @entity7 . Furthermore, an oncolytic adenovirus, whose replication is under the control of the MK promoter, inhibits the growth of @entity7 xenografts. MK inhibitors under development include antibodies, aptamers, glycosaminoglycans, peptides and low molecular weight compounds. siRNA and antisense oligoDNA have proved effective against @entity0 and inflammatory diseases in experimental systems. Practical information concerning the development of MK and MK inhibitors as therapeutics is described in the final part of the review.

title: XXXX : a promising molecule for drug development to treat diseases of the central nervous system.

answer: @entity8


abstract: The potential role of the detection of residual @entity2 after @entity3 ( @entity3 ) in the differentiation of @entity0 at risk for recurrent @entity4 ( @entity4 ) has not yet been fully established and includes different definitions. We performed a systematic review in order to determine the role of residual @entity2 in predicting recurrent @entity4 after acute proximal @entity3 . Databases were searched until June 2010. Randomized, controlled trials or prospective cohort studies were eligible for inclusion if they included @entity0 with objectively diagnosed proximal @entity3 , measured thrombus diameter after at least 3   months and reported recurrent @entity4 during follow-up. Two authors independently reviewed articles and extracted data. Data from 11 studies were used for the current analysis; in total 3203 @entity0 were included. Residual @entity2 was positively correlated with recurrent @entity4 . Large heterogeneity was present, due to differences in study population, timing and the differences in method of measuring residual @entity2 . The effect was more pronounced in @entity0 with @entity1 or was dependent on the criteria used. This systematic review shows a positive relationship between residual @entity2 and recurrent @entity4 during follow-up. Assessing residual @entity2 could be useful in individual recurrence risk estimation.

title: Residual venous thrombosis as predictive factor for recurrent XXXX in @entity0 with proximal @entity3 : a sytematic review.

answer: @entity4


abstract: The potential role of the detection of residual @entity2 after @entity3 ( @entity3 ) in the differentiation of @entity0 at risk for recurrent @entity4 ( @entity4 ) has not yet been fully established and includes different definitions. We performed a systematic review in order to determine the role of residual @entity2 in predicting recurrent @entity4 after acute proximal @entity3 . Databases were searched until June 2010. Randomized, controlled trials or prospective cohort studies were eligible for inclusion if they included @entity0 with objectively diagnosed proximal @entity3 , measured thrombus diameter after at least 3   months and reported recurrent @entity4 during follow-up. Two authors independently reviewed articles and extracted data. Data from 11 studies were used for the current analysis; in total 3203 @entity0 were included. Residual @entity2 was positively correlated with recurrent @entity4 . Large heterogeneity was present, due to differences in study population, timing and the differences in method of measuring residual @entity2 . The effect was more pronounced in @entity0 with @entity1 or was dependent on the criteria used. This systematic review shows a positive relationship between residual @entity2 and recurrent @entity4 during follow-up. Assessing residual @entity2 could be useful in individual recurrence risk estimation.

title: Residual venous thrombosis as predictive factor for recurrent @entity4 in @entity0 with proximal XXXX : a sytematic review.

answer: @entity3


abstract: The potential role of the detection of residual @entity2 after @entity3 ( @entity3 ) in the differentiation of @entity0 at risk for recurrent @entity4 ( @entity4 ) has not yet been fully established and includes different definitions. We performed a systematic review in order to determine the role of residual @entity2 in predicting recurrent @entity4 after acute proximal @entity3 . Databases were searched until June 2010. Randomized, controlled trials or prospective cohort studies were eligible for inclusion if they included @entity0 with objectively diagnosed proximal @entity3 , measured thrombus diameter after at least 3   months and reported recurrent @entity4 during follow-up. Two authors independently reviewed articles and extracted data. Data from 11 studies were used for the current analysis; in total 3203 @entity0 were included. Residual @entity2 was positively correlated with recurrent @entity4 . Large heterogeneity was present, due to differences in study population, timing and the differences in method of measuring residual @entity2 . The effect was more pronounced in @entity0 with @entity1 or was dependent on the criteria used. This systematic review shows a positive relationship between residual @entity2 and recurrent @entity4 during follow-up. Assessing residual @entity2 could be useful in individual recurrence risk estimation.

title: Residual venous thrombosis as predictive factor for recurrent @entity4 in XXXX with proximal @entity3 : a sytematic review.

answer: @entity0


abstract: BACKGROUND: Disease severity in @entity0 with @entity1 ( @entity1 ) is often assessed using walking distances and treadmill tests. The aim of this study was to determine the agreement between walking distance as estimated by the @entity0 , as measured during outside walking, and as determined using a nongraded treadmill protocol (NGTP), and an incremental graded ( @entity2 ) treadmill protocol ( @entity3 ). METHODS: In this prospective observational study, 30 @entity0 with @entity1 estimated their maximal walking distance (MWD) and completed a "Walking Impairment Questionnaire" (WIQ). Outside walking was determined using a measuring wheel and a @entity3 controlled device. Primary outcomes were differences in MWD and variability (coefficient of variation, COV). Secondary outcomes were results of WIQ and differences in walking speed. RESULTS: Estimated walking distance was significantly higher than MWD as objectively measured during outside walking (400 m vs. 309 m, respectively, P  =  0.02). A substantial variability (COV  =  55%) was found between both parameters. A small 35-m MWD difference between outside walking and @entity3 was found with a substantial scatter (COV  =  42%). In contrast, a much larger 122-m MWD difference was present between outside walking and NGTP (COV = 89%). @entity0 walked significantly faster in the open air than on treadmills (median outside walking speed  =  3.8  km/hr, @entity3  =  3.2  km/hr, NGTP  =  2.8  km/hr; P  <  0.001). CONCLUSIONS: An incremental graded ( @entity2 ) treadmill protocol demonstrated the best agreement to outside walking. Discrepancies between treadmill tests and outside walking may be explained by a difference in walking speed. A single determination of a walking distance is a poor reflection of true walking capacity.

title: Agreements and Discrepancies between the  Estimated Walking Distance, Nongraded and Graded Treadmill Testing, and Outside Walking in @entity0 with XXXX .

answer: @entity1


abstract: BACKGROUND: Disease severity in @entity0 with @entity1 ( @entity1 ) is often assessed using walking distances and treadmill tests. The aim of this study was to determine the agreement between walking distance as estimated by the @entity0 , as measured during outside walking, and as determined using a nongraded treadmill protocol (NGTP), and an incremental graded ( @entity2 ) treadmill protocol ( @entity3 ). METHODS: In this prospective observational study, 30 @entity0 with @entity1 estimated their maximal walking distance (MWD) and completed a "Walking Impairment Questionnaire" (WIQ). Outside walking was determined using a measuring wheel and a @entity3 controlled device. Primary outcomes were differences in MWD and variability (coefficient of variation, COV). Secondary outcomes were results of WIQ and differences in walking speed. RESULTS: Estimated walking distance was significantly higher than MWD as objectively measured during outside walking (400 m vs. 309 m, respectively, P  =  0.02). A substantial variability (COV  =  55%) was found between both parameters. A small 35-m MWD difference between outside walking and @entity3 was found with a substantial scatter (COV  =  42%). In contrast, a much larger 122-m MWD difference was present between outside walking and NGTP (COV = 89%). @entity0 walked significantly faster in the open air than on treadmills (median outside walking speed  =  3.8  km/hr, @entity3  =  3.2  km/hr, NGTP  =  2.8  km/hr; P  <  0.001). CONCLUSIONS: An incremental graded ( @entity2 ) treadmill protocol demonstrated the best agreement to outside walking. Discrepancies between treadmill tests and outside walking may be explained by a difference in walking speed. A single determination of a walking distance is a poor reflection of true walking capacity.

title: Agreements and Discrepancies between the  Estimated Walking Distance, Nongraded and Graded Treadmill Testing, and Outside Walking in XXXX with @entity1 .

answer: @entity0


abstract: INTRODUCTION: Operative laparoscopy is the most common used technique for treatment of @entity0 with @entity1 , because of many positive effects in comparison with laparotomy. There are many laparoscopic techniques, but most used are cystectomy and puncture with endocoagulation (ablation) of the cyst's capsule. The aim of this study was to evaluate the effect of two laparoscopic techniques for treatment of @entity1 on ovarian reserve. We used two ultrasonographic markers for ovarian reserve: ovarian volume and antral follicle count (AFC). MATERIALS AND METHODS: Sixty @entity0 in reproductive age (18-42 years) were treated for a chronic pelvic @entity3 or @entity4 in a tertiary hospital (University Clinic for Gynecology and Obstetrics in Skopje, R. Macedonia). The study was prospective and two laparoscopic techniques were used. All @entity0 were with confirmed ultrasound diagnosis for @entity1 with diameter between 3 and 8 cm. Complete cystectomy was done in 30 @entity0 (group A) and puncture with endocoagulation was done in other 30 @entity0 (group B). Ovarian reserve was analyzed before surgery and was controlled one and three months after laparoscopic surgery. RESULTS: In group A (operated with cystectomy) ovarian volume was 53.46  29.97 cm   before surgery, which fell to 13.06  7.34 cm   after one month, and 13.28  7.17 cm   after three months. Statistical analysis showed a significant @entity5 and three months after surgery (p <=0.01). In group B (operated with puncture and endocoagulation) the ovarian volume was 58.34  37.99 cm   before surgery, which fell to 18.96  7.90 cm   one month and 17.38  6.86 cm   three months after surgery. In both groups there was a significant @entity5 and three months postoperatively (p <=0.01). In the first group AFC was 3.03  1.27 before surgery, 4.8  1.30 one month after surgery and 6.23  1.57 after three months. Statistical analysis showed a significant increase in AFC after laparoscopic cystectomy (p <=0.01). In the second group AFC was 3.07  1.05 before surgery, 5.33  1.60 after one month and 7.0  1.62 after three months. The comparison of AFC showed high statistically significant difference (p <=0.001), e.g. increase of AFC after one and three months in comparison with AFC before surgery. CONCLUSIONS: Ovarian reserve decreases after laparoscopic surgery using both laparoscopic techniques. But, this decrease was more frequent using cystectomy in comparison with ablation of the @entity2 .

title: Effect of Two Laparoscopic Techniques for Treatment of XXXX on Ovarian Reserve.

answer: @entity1


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity3 are registered during the use of selective @entity4 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity1 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity6 , @entity7 and @entity5 . MATERIAL AND METHODS: The study included 90 in- @entity0 as well as outpatients of both sexes aged 18-65 who were treated for major @entity2 at Psychiatric Clinic in Banjaluka. 30 @entity0 were treated with @entity7 75-250 mg, 30 @entity0 were treated with @entity5 20-40 mg and 30 @entity0 were treated with @entity6 75-300 mg. The selection of @entity0 was done on the basis of diagnosis of major @entity2 . RESULTS: Most @entity0 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity5 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of @entity6 , @entity5 and @entity7 in XXXX Therapy.

answer: @entity2


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity3 are registered during the use of selective @entity4 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity1 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity6 , @entity7 and @entity5 . MATERIAL AND METHODS: The study included 90 in- @entity0 as well as outpatients of both sexes aged 18-65 who were treated for major @entity2 at Psychiatric Clinic in Banjaluka. 30 @entity0 were treated with @entity7 75-250 mg, 30 @entity0 were treated with @entity5 20-40 mg and 30 @entity0 were treated with @entity6 75-300 mg. The selection of @entity0 was done on the basis of diagnosis of major @entity2 . RESULTS: Most @entity0 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity5 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of XXXX , @entity5 and @entity7 in @entity2 Therapy.

answer: @entity6


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity3 are registered during the use of selective @entity4 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity1 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity6 , @entity7 and @entity5 . MATERIAL AND METHODS: The study included 90 in- @entity0 as well as outpatients of both sexes aged 18-65 who were treated for major @entity2 at Psychiatric Clinic in Banjaluka. 30 @entity0 were treated with @entity7 75-250 mg, 30 @entity0 were treated with @entity5 20-40 mg and 30 @entity0 were treated with @entity6 75-300 mg. The selection of @entity0 was done on the basis of diagnosis of major @entity2 . RESULTS: Most @entity0 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity5 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of @entity6 , @entity5 and XXXX in @entity2 Therapy.

answer: @entity7


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity3 are registered during the use of selective @entity4 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity1 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity6 , @entity7 and @entity5 . MATERIAL AND METHODS: The study included 90 in- @entity0 as well as outpatients of both sexes aged 18-65 who were treated for major @entity2 at Psychiatric Clinic in Banjaluka. 30 @entity0 were treated with @entity7 75-250 mg, 30 @entity0 were treated with @entity5 20-40 mg and 30 @entity0 were treated with @entity6 75-300 mg. The selection of @entity0 was done on the basis of diagnosis of major @entity2 . RESULTS: Most @entity0 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity5 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of @entity6 , XXXX and @entity7 in @entity2 Therapy.

answer: @entity5


abstract: The purpose of the use of this methodology is 1) to advance our capacity to protect individuals with antibody or vaccine for preventing or treating @entity5 caused by the fungus @entity4 and 2) to examine the role of virulence factors as target for therapy. To generate mAbs, @entity1 are immunized, the immune responses are assessed using a solid phase ELISA system developed in our laboratory, and the best responder @entity1 are selected for isolation of splenocytes for fusion with hybridoma cells. C57BL/6 @entity1 have been extensively used to study @entity4 pathogenesis and provide the best model for obtaining the data required. In order to assess the role of the mAbs in @entity2 , @entity1 are intraperitoneally administered with either mAb to @entity4 or isotype matched control mAb and then infected by either intravenous (i.v.), intraperitoneal (i.p.), or intranasal (i.n.) routes. In the scientific literature, efficacy of mAbs for @entity3 in @entity1 relies on mortality as an end point, in conjunction with colony forming units (CFU) assessments at earlier time points. Survival (time to death) studies are necessary as they best represent @entity0 disease. Thus, efficacy of our intervention would not adequately be established without survival curves. This is also true for establishing efficacy of vaccine or testing of mutants for virulence. With @entity5 , the @entity1 often go from being energetic to dead over several hours. The capacity of an intervention such as the administration of a mAb may initially protect an animal from disease, but the disease can relapse which would not be realized in short CFU experiments. In addition to survival and fungal burden assays, we examine the inflammatory responses to @entity2 (histology, cellular recruitment, cytokine responses). For survival/time to death experiments, the @entity1 are infected and monitored at least twice daily for signs of morbidity. To assess fungal burden, histopathology, and cytokine responses, the @entity1 are euthanized at various times after @entity2 . Animal experiments are performed according to the guidelines of the Institute for Animal Studies of the Albert Einstein College of Medicine.

title: Passive administration of monoclonal antibodies against XXXX and other fungal pathogens.

answer: @entity4


abstract: For some moth species, especially those closely interrelated and sympatric, recognizing a specific @entity1 component concentration ratio is essential for males to successfully locate conspecific females. We propose and determine the properties of a minimalist competition-based feed-forward neuronal model capable of detecting a certain ratio of @entity1 components independently of overall concentration. This model represents an elementary recognition unit for the ratio of binary mixtures which we propose is entirely contained in the macroglomerular complex (MGC) of the male moth. A set of such units, along with projection neurons (PNs), can provide the input to higher brain centres. We found that (1) accuracy is mainly achieved by maintaining a certain ratio of connection strengths between olfactory receptor neurons (ORN) and @entity0 ( @entity0 ), much less by properties of the interconnections between the competing LNs proper. An exception to this rule is that it is beneficial if connections between generalist LNs (i.e. excited by either @entity1 component) and specialist LNs (i.e. excited by one component only) have the same strength as the reciprocal specialist to generalist connections. (2) successful ratio recognition is achieved using latency-to-first-spike in the @entity0 populations which, in contrast to expectations with a population rate code, leads to a broadening of responses for higher overall concentrations consistent with experimental observations. (3) when longer durations of the competition between LNs were observed it did not lead to higher recognition accuracy.

title: Competition-based model of XXXX component ratio detection in the moth.

answer: @entity1


abstract: OBJECTIVE: After solid organ transplantation, risk of @entity1 varies significantly based on @entity1 type. In this study, we determine the incidence of @entity1 (bladder and kidney) after renal transplantation from a single high-volume transplantation institution. In addition, we analyze the risk factors and review outcomes from the @entity0 . MATERIALS AND METHODS: We performed a retrospective review of all @entity0 in the University of Alabama at Birmingham (UAB) transplant database to identify all @entity0 who received renal transplants at UAB between January 1, 1990, and January 1, 2010. We further identified transplant @entity0 diagnosed with bladder, urothelial of other @entity1 in the same time period. We also examined @entity1 -specific variables such as presentation, clinical and pathologic staging, treatment type, recurrence, progression, interval to recurrence and progression, @entity1 -specific mortality, and interval from time to diagnosis to @entity4 . RESULTS: Review of the transplant database confirmed 5,920 renal transplants. Thirteen @entity0 underwent the diagnosis of @entity1 , providing an incidence of 0.2%. Eight @entity0 had @entity3 for an incidence of 0.13%, compared to an incidence of 0.02% among the general population. @entity0 diagnosed with @entity3 after renal transplantation were younger than those in the general population and frequently present with more advanced and @entity2 . CONCLUSIONS: @entity0 are at an elevated risk of @entity1 after renal transplantation probably from immune suppression.

title: XXXX after renal transplantation.

answer: @entity1


abstract: AIMS: To test a simulation model, the MICADO model, for estimating the long-term effects of interventions in @entity0 with and without @entity1 . METHODS: The MICADO model includes micro- and @entity2 in relation to their risk factors. The strengths of this model are its population scope and the possibility to assess parameter uncertainty using probabilistic sensitivity analyses. Outcomes include incidence and prevalence of complications, quality of life, costs and cost-effectiveness. We externally validated MICADO's estimates of micro- and macrovascular complications in a Dutch cohort with @entity1 (n  =  498 400) by comparing these estimates with national and international empirical data. RESULTS: For the annual number of @entity0 undergoing amputations, MICADO's estimate was 592 (95% interquantile range 291-842), which compared well with the registered number of @entity0 with @entity1 -related amputations in the Netherlands (728). The incidence of @entity3 estimated using the MICADO model was 247 @entity0 (95% interquartile range 120-363), which was also similar to the registered incidence in the Netherlands (277 @entity0 ). MICADO performed well in the validation of macrovascular outcomes of population-based cohorts, while it had more difficulty in reflecting a highly selected trial population. CONCLUSIONS: Validation by comparison with independent empirical data showed that the MICADO model simulates the natural course of @entity1 and its micro- and macrovascular complications well. As a population-based model, MICADO can be applied for projections as well as scenario analyses to evaluate the long-term (cost-)effectiveness of population-level interventions targeting @entity1 and its complications in the Netherlands or similar countries.

title: Policy evaluation in XXXX prevention and treatment using a population-based macro simulation model: the MICADO model.

answer: @entity1


abstract: OBJECTIVE: To identify the presence of orexin receptor 1 (OXR1) in @entity0 @entity1 pancreas and clarify its effect and mechanism on body weight and metabolic index in @entity0 @entity1 . METHODS: The @entity0 @entity1 model was established a high-fat diet. And the serum levels of @entity4 , @entity3 and insulin were measured by Mini-Blood @entity4 meter, biochemical enzymatic method and chemiluminescent immunoassay. The pancreatic expression of @entity5 protein was identified by immunohistochemistry. After an intracerebroventricular infusion of orexin receptor 1 antisense oligodeoxynucleotide ( @entity5 -PS-ODNs), the effect on @entity5 protein was detected in @entity1 pancreatic tissue with @entity0 . RESULTS: After feeding for 8 weeks, high-fat diet @entity1 appear @entity0 body weight, serum @entity4 , insulin, @entity3 and @entity2 of high-diet @entity1 were higher than those in the control group (P < 0.05). The expression of @entity5 protein was located in the cytoplasm of pancreas Islet b-cells. The expression of @entity5 protein in @entity0 @entity1 pancreas decreased around 16% versus the normal group (P < 0.05). After the @entity0 @entity1 were treated by @entity5 -PS-ODNs for 72 hours, the expression of @entity5 protein in pancreas declined from 82    6 to 65    4, reduced about 21% compare with control group (P < 0.01). CONCLUSION: The expression of @entity5 protein is found in pancreas Islet b-cells. Hypothalamic orexin system can intervene the expression of @entity5 protein in @entity1 pancreatic tissue with @entity0 . And it may participate in the occurrence of @entity0 and the metabolic regulation of serum @entity4 and insulin.

title: [Expression of orexin receptor 1 in @entity1 pancreatic tissue with XXXX ].

answer: @entity0


abstract: OBJECTIVE: To identify the presence of orexin receptor 1 (OXR1) in @entity0 @entity1 pancreas and clarify its effect and mechanism on body weight and metabolic index in @entity0 @entity1 . METHODS: The @entity0 @entity1 model was established a high-fat diet. And the serum levels of @entity4 , @entity3 and insulin were measured by Mini-Blood @entity4 meter, biochemical enzymatic method and chemiluminescent immunoassay. The pancreatic expression of @entity5 protein was identified by immunohistochemistry. After an intracerebroventricular infusion of orexin receptor 1 antisense oligodeoxynucleotide ( @entity5 -PS-ODNs), the effect on @entity5 protein was detected in @entity1 pancreatic tissue with @entity0 . RESULTS: After feeding for 8 weeks, high-fat diet @entity1 appear @entity0 body weight, serum @entity4 , insulin, @entity3 and @entity2 of high-diet @entity1 were higher than those in the control group (P < 0.05). The expression of @entity5 protein was located in the cytoplasm of pancreas Islet b-cells. The expression of @entity5 protein in @entity0 @entity1 pancreas decreased around 16% versus the normal group (P < 0.05). After the @entity0 @entity1 were treated by @entity5 -PS-ODNs for 72 hours, the expression of @entity5 protein in pancreas declined from 82    6 to 65    4, reduced about 21% compare with control group (P < 0.01). CONCLUSION: The expression of @entity5 protein is found in pancreas Islet b-cells. Hypothalamic orexin system can intervene the expression of @entity5 protein in @entity1 pancreatic tissue with @entity0 . And it may participate in the occurrence of @entity0 and the metabolic regulation of serum @entity4 and insulin.

title: [Expression of orexin receptor 1 in XXXX pancreatic tissue with @entity0 ].

answer: @entity1


abstract: OBJECTIVE: To evaluate the characteristics of papillary structure of @entity2 on MSCT (multiple-slice spiral computed tomography) for the diagnosis of @entity2 . METHODS: Thirty-five cases of @entity2 pathologically confirmed with plain and contrast MSCT data from March 2003 to April 2010 were retrospectively analyzed. The number, margin, shape, enhancement behavior, location, @entity1 and the delineation of papillary structure were compared by the stata 10.1 software. RESULTS: There were statistically significant differences between @entity0 , @entity0 and @entity4 in margin, shape and location of papillary structure (P < 0.05). @entity3 was most commonly located in central part with an indistinct margin. Psammoma, such as microcalcification, was characteristic of @entity0 . Coarse and peripheral @entity1 was commonly observed in @entity4 . No statistical difference existed in the number and internal septa of papillary structure among @entity0 , @entity0 and @entity4 (P > 0.05). It could offer a more distinct visualization of papillary structure during the venous phase. CONCLUSION: The features of papillary structure on MSCT of various @entity2 may help make the differential diagnosis of @entity2 .

title: [Characteristics of papillary structure of XXXX on multiple-slice spiral computed tomography for the diagnosis of @entity2 ].

answer: @entity2


abstract: OBJECTIVE: To evaluate the characteristics of papillary structure of @entity2 on MSCT (multiple-slice spiral computed tomography) for the diagnosis of @entity2 . METHODS: Thirty-five cases of @entity2 pathologically confirmed with plain and contrast MSCT data from March 2003 to April 2010 were retrospectively analyzed. The number, margin, shape, enhancement behavior, location, @entity1 and the delineation of papillary structure were compared by the stata 10.1 software. RESULTS: There were statistically significant differences between @entity0 , @entity0 and @entity4 in margin, shape and location of papillary structure (P < 0.05). @entity3 was most commonly located in central part with an indistinct margin. Psammoma, such as microcalcification, was characteristic of @entity0 . Coarse and peripheral @entity1 was commonly observed in @entity4 . No statistical difference existed in the number and internal septa of papillary structure among @entity0 , @entity0 and @entity4 (P > 0.05). It could offer a more distinct visualization of papillary structure during the venous phase. CONCLUSION: The features of papillary structure on MSCT of various @entity2 may help make the differential diagnosis of @entity2 .

title: [Characteristics of papillary structure of @entity2 on multiple-slice spiral computed tomography for the diagnosis of XXXX ].

answer: @entity2


abstract: OBJECTIVES/HYPOTHESIS: To examine associations between quality of care, short- and long-term treatment-related outcomes, and costs in elderly @entity0 treated for @entity8 ( @entity8 ). STUDY DESIGN: Retrospective analysis of Surveillance, Epidemiology, and End Results-Medicare data. METHODS: We evaluated longitudinal data from 2,370 @entity0 diagnosed with laryngeal @entity8 from 2004 to 2007 using cross-tabulations, multivariate regression, and survival analysis. Using quality indicators derived from guidelines for recommended care and performance measures, an overall summary measure of quality was calculated incorporating summary quality measures for diagnosis, initial treatment, performance, surveillance, treatment for recurrence, and end-of-life care. RESULTS: Higher-quality care was associated with a lower likelihood of long-term @entity4 (odds ratio [OR]   =   0.6 [0.5-0.8]), stricture (OR   =   0.5 [0.3-0.8]), @entity5 (OR   =   0.5 [0.4-0.7]), @entity6 (OR   =   0.7 [0.6-0.9]), tracheostomy (OR   =   0.5 [0.3-0.7]), and @entity2 (OR   =   0.7 [0.5-0.9]), but had no impact on the likelihood of @entity7 . Higher-quality care was associated with lower risk of @entity3 in @entity0 with @entity7 (hazard ratio [HR]   =   0.7 [0.6-0.8]), @entity4 (HR   =   0.8 [0.6-0.9]), @entity6 (HR   =   0.7 [0.6-0.8]), tracheostomy (HR   =   0.7 [0.5-0.9]), and @entity2 (HR   =   0.8 [0.6-0.9]), but was not associated with survival differences in @entity0 with @entity5 or stricture. Costs associated with @entity7 , @entity4 , stricture, @entity6 , and @entity2 were lower for @entity0 receiving higher-quality care. CONCLUSIONS: Higher-quality @entity1 care was associated with a reduced incidence of late airway and swallowing impairment after laryngeal @entity8 treatment in elderly @entity0 , with improved survival and reduced costs. These data suggest that greater attention to evidence-based practices associated with quality indicators may lead to improved functional outcomes in the elderly. LEVEL OF EVIDENCE: 2c.

title: Quality of care and short- and long-term outcomes of XXXX care in the elderly.

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) is associated with @entity2 , yet the underlying pathophysiology of this disease and the @entity3 remain poorly understood. Low-density lipoprotein receptor-related protein ( @entity5 ) is implicated in the pathogenesis of @entity1 by mediating the transport of amyloid-b (Ab) out of the brain into the systemic circulation. As a key player in the reaction to central @entity4 , astrocytes associate with @entity5 in @entity1 . This study investigates the role of @entity5 and astrocytes in the pathogenesis of @entity3 . METHODS: To investigate the role of @entity5 and astrocytes in the pathogenesis of @entity3 , we conducted immunohistochemical studies on postmortem optic nerves in @entity1 @entity0 (n = 11) and age-matched controls (n = 10) to examine the presence of @entity5 . Quantitative analyses using imaging software were used to document the extent of @entity5 in neural tissues. Axonal integrity was assessed by performing immunohistochemistry on the subjects' optic nerves with an antibody to neurofilament (NF) protein. Double-immunofluorescence labeling was performed to investigate whether @entity5 colocalized with astrocytes, expressing glial fibrillary acidic protein. RESULTS: @entity5 expression was decreased in @entity1 optic nerves compared to that in controls (P < 0.001). @entity5 immunoreactivity was observed in the microvasculature and perivascularly in close proximity to the astrocytic processes. Colocalization of @entity5 in the astrocytes of optic nerves was also demonstrated. The presence of @entity3 was confirmed in the @entity1 optic nerves by demonstrating greatly reduced immunostaining for NF protein as compared to controls. CONCLUSIONS: The reduction of @entity5 in the @entity3 supports the hypothesis that @entity5 may play a role in the pathophysiology of @entity3 .

title: Low-density lipoprotein receptor-related protein is decreased in XXXX of @entity1 .

answer: @entity3


abstract: BACKGROUND: @entity1 ( @entity1 ) is associated with @entity2 , yet the underlying pathophysiology of this disease and the @entity3 remain poorly understood. Low-density lipoprotein receptor-related protein ( @entity5 ) is implicated in the pathogenesis of @entity1 by mediating the transport of amyloid-b (Ab) out of the brain into the systemic circulation. As a key player in the reaction to central @entity4 , astrocytes associate with @entity5 in @entity1 . This study investigates the role of @entity5 and astrocytes in the pathogenesis of @entity3 . METHODS: To investigate the role of @entity5 and astrocytes in the pathogenesis of @entity3 , we conducted immunohistochemical studies on postmortem optic nerves in @entity1 @entity0 (n = 11) and age-matched controls (n = 10) to examine the presence of @entity5 . Quantitative analyses using imaging software were used to document the extent of @entity5 in neural tissues. Axonal integrity was assessed by performing immunohistochemistry on the subjects' optic nerves with an antibody to neurofilament (NF) protein. Double-immunofluorescence labeling was performed to investigate whether @entity5 colocalized with astrocytes, expressing glial fibrillary acidic protein. RESULTS: @entity5 expression was decreased in @entity1 optic nerves compared to that in controls (P < 0.001). @entity5 immunoreactivity was observed in the microvasculature and perivascularly in close proximity to the astrocytic processes. Colocalization of @entity5 in the astrocytes of optic nerves was also demonstrated. The presence of @entity3 was confirmed in the @entity1 optic nerves by demonstrating greatly reduced immunostaining for NF protein as compared to controls. CONCLUSIONS: The reduction of @entity5 in the @entity3 supports the hypothesis that @entity5 may play a role in the pathophysiology of @entity3 .

title: Low-density lipoprotein receptor-related protein is decreased in @entity3 of XXXX .

answer: @entity1


abstract: @entity1 ( @entity1 ) is defined as a state of persistent @entity5 with no identifiable etiology in @entity0 without preexisting @entity3 that lasts longer than 24h despite optimal therapy. Management of @entity1 is challenging, and the role of immunotherapy (IT) is unclear. We identified @entity0 fulfilling the criteria for @entity1 at a single institution. These @entity0 were described, analyzed, and compared with @entity1 cases available from the literature. Finally, a pooled analysis of available case series was conducted to compare the outcomes in @entity0 who received IT with those not treated with IT during the course of @entity1 in order to generate hypotheses for further research. In our case series, @entity1 was diagnosed in 11 @entity0 (9 females) with a mean age of 48 years and a mean duration of 54.4 days. Autoantibodies were identified in 7 @entity0 , of which anti- @entity7 ( @entity4 decarboxylase) and anti-NMDAR ( @entity6 receptor) were most frequent. Of the 11 @entity0 , 8 were treated with IT (intravenous @entity2 , immunoglobulins, plasmapheresis, or a combination), and 4 received chemotherapy. Of the 8 @entity0 treated with IT, 6 had favorable outcomes (defined as any outcome other than death, vegetative state, or inability to take care of oneself) compared with 0 out of 3 @entity0 who did not receive IT. Difference in outcomes was significant (p=0.026). Pooled analysis of all identified case series, including ours, showed a statistically significant effect (p=0.022), with favorable outcomes in 42% of the @entity0 who received any IT compared with 20% in those who did not. In all @entity0 with refractory SE and negative comprehensive investigations, a diagnosis of @entity1 should be considered. This would aid planning for early immunotherapy. Currently, only Class IV evidence for the use of immunotherapy in @entity1 is available. Prospective multicenter studies are necessary to assess the true efficacy of IT in @entity1 .

title: XXXX ( @entity1 )--The potential role for immunotherapy.

answer: @entity1


abstract: @entity1 ( @entity1 ) is defined as a state of persistent @entity5 with no identifiable etiology in @entity0 without preexisting @entity3 that lasts longer than 24h despite optimal therapy. Management of @entity1 is challenging, and the role of immunotherapy (IT) is unclear. We identified @entity0 fulfilling the criteria for @entity1 at a single institution. These @entity0 were described, analyzed, and compared with @entity1 cases available from the literature. Finally, a pooled analysis of available case series was conducted to compare the outcomes in @entity0 who received IT with those not treated with IT during the course of @entity1 in order to generate hypotheses for further research. In our case series, @entity1 was diagnosed in 11 @entity0 (9 females) with a mean age of 48 years and a mean duration of 54.4 days. Autoantibodies were identified in 7 @entity0 , of which anti- @entity7 ( @entity4 decarboxylase) and anti-NMDAR ( @entity6 receptor) were most frequent. Of the 11 @entity0 , 8 were treated with IT (intravenous @entity2 , immunoglobulins, plasmapheresis, or a combination), and 4 received chemotherapy. Of the 8 @entity0 treated with IT, 6 had favorable outcomes (defined as any outcome other than death, vegetative state, or inability to take care of oneself) compared with 0 out of 3 @entity0 who did not receive IT. Difference in outcomes was significant (p=0.026). Pooled analysis of all identified case series, including ours, showed a statistically significant effect (p=0.022), with favorable outcomes in 42% of the @entity0 who received any IT compared with 20% in those who did not. In all @entity0 with refractory SE and negative comprehensive investigations, a diagnosis of @entity1 should be considered. This would aid planning for early immunotherapy. Currently, only Class IV evidence for the use of immunotherapy in @entity1 is available. Prospective multicenter studies are necessary to assess the true efficacy of IT in @entity1 .

title: @entity1 ( XXXX )--The potential role for immunotherapy.

answer: @entity1


abstract: PURPOSE: The duration of follow-up after treatment of @entity3 and the frequency of routine visits are based on common usage rather than evidence-based practice. The purpose of this study was to determine the appropriate postoperative routine follow-up program in @entity0 with @entity3 . @entity0 AND METHODS: Three hundred four cases treated curatively mainly by surgery at Tokai University Hospital from 1994 to 2004 were analyzed. A secondary event was defined as a local recurrence, a regional recurrence, a distant @entity1 , or a second @entity2 . To evaluate the follow-up program, data on the first @entity2 recurrence or first second @entity2 in the head and neck region or elsewhere in the body were used. Overall survival rate, disease-specific survival rate, relapse-free rate, and cumulative risk of developing a second @entity2 were estimated by the Kaplan-Meier product limit method. RESULT: All relapse cases were detected within 3 years postoperatively, of which 86.3% were detected within 1 year. Most relapses were in the neck, and regional recurrences had a dismal salvage rate. Second @entity2 were constantly detected 1 to 10 years postoperatively. CONCLUSION: Follow-up should be performed more frequently in the first year, with 2 weekly follow-ups with monthly ultrasound examinations, and should be continued after 3 years to exclude the development of second @entity2 .

title: Postoperative follow-up strategy in @entity0 with XXXX .

answer: @entity3


abstract: PURPOSE: The duration of follow-up after treatment of @entity3 and the frequency of routine visits are based on common usage rather than evidence-based practice. The purpose of this study was to determine the appropriate postoperative routine follow-up program in @entity0 with @entity3 . @entity0 AND METHODS: Three hundred four cases treated curatively mainly by surgery at Tokai University Hospital from 1994 to 2004 were analyzed. A secondary event was defined as a local recurrence, a regional recurrence, a distant @entity1 , or a second @entity2 . To evaluate the follow-up program, data on the first @entity2 recurrence or first second @entity2 in the head and neck region or elsewhere in the body were used. Overall survival rate, disease-specific survival rate, relapse-free rate, and cumulative risk of developing a second @entity2 were estimated by the Kaplan-Meier product limit method. RESULT: All relapse cases were detected within 3 years postoperatively, of which 86.3% were detected within 1 year. Most relapses were in the neck, and regional recurrences had a dismal salvage rate. Second @entity2 were constantly detected 1 to 10 years postoperatively. CONCLUSION: Follow-up should be performed more frequently in the first year, with 2 weekly follow-ups with monthly ultrasound examinations, and should be continued after 3 years to exclude the development of second @entity2 .

title: Postoperative follow-up strategy in XXXX with @entity3 .

answer: @entity0


abstract: PURPOSE: The purpose of this case series study was to evaluate the advantages and disadvantages of using local anesthesia and conscious sedation (CS) rather than general anesthesia (GA) for performing functional surgery on @entity0 suffering from @entity3 ( @entity3 ) closed lock, using the eminectomy procedure. Performing this procedure using CS allows functional assessment of the @entity3 meniscus at the time of surgery. The objectives of this study were to determine if this surgery is possible under CS, to determine the benefits of being able to see the meniscus in action, and to investigate the @entity0 ' acceptability for this form of anesthesia. @entity0 AND METHODS: Twenty-two @entity0 who underwent this eminectomy procedure under either CS or GA on a day-case basis participated in this retrospective case series study. All the recruited @entity0 had this procedure carried out after a course of nonsurgical conservative treatment that had failed to relieve the symptoms associated with their @entity3 disorder--"closed lock." RESULTS: Objective results obtained were as follows: preoperative and @entity1 opening; preoperative investigations; preoperative treatments. Subjective results obtained were as follows: preoperative and postoperative @entity2 ; noises; clicks; hearing and deviation on opening; @entity0 rating of operation success. Paired t testing showed a significant change in mouth opening for both groups. The mean mouth opening change in the CS group (n = 9) was 10.6 mm (P = .014) and in the GA group (n = 13) was 13.7 mm (P < .001). An unpaired t test showed there is no statistical difference between these groups (P = .467). The subjective data recorded showed comparable outcomes and acceptance for the 2 techniques in terms of @entity2 and operation success. CONCLUSIONS: The use of local anesthesia and CS is an alternative to GA for performing @entity3 procedures in appropriately selected @entity0 . The advantage of direct visualization of the meniscus and its movements in the nonasleep @entity0 requires further evaluation.

title: Functional surgery of the XXXX with conscious sedation for "closed lock" using eminectomy as a treatment: a case series.

answer: @entity3


abstract: UNASSIGNED: The incidences of both @entity6 ( @entity6 ) and @entity7 are increasing worldwide. @entity7 is associated with many @entity2 . However, no data are available on @entity2 of unknown primary (CUP), a relatively common, fatal @entity2 for which @entity4 smoking is the only known risk factor. At diagnosis, CUP @entity1 are found in various organs, which has implications for prognosis. We carried out a nationwide study on the association of CUP with @entity6 and @entity7 . 32   600 @entity6 @entity0 and 178   000 @entity7 @entity0 were identified from the national healthcare registers and these were linked to the Swedish @entity2 Registry. Standardized incidence ratios (SIRs) were calculated for CUP from 1997 through 2010 using anyone without @entity3 as a reference. The SIR of CUP in 421 @entity3 @entity0 was 1.71, highest for CUP with liver (2.17) and respiratory system (1.95) @entity1 . The SIR was 2.91 for @entity6 , but with a small number of @entity0 , 1.38 for @entity7 with insulin treatment, and 1.78 for the main group of @entity7 . CUP with liver and respiratory system @entity1 increased for each @entity3 type; however, for @entity7 , CUP with @entity5 also increased. The results provide the first demonstration that CUP is one of the @entity2 associated with @entity3 , with definite evidence on @entity7 . CUP has a poor prognosis, which may be even worse when @entity3 is the underlying comorbidity. A mechanistic question for future work is to determine whether @entity3 promotes primaries that escape detection or their metastatic spread.

title: @entity2 of unknown primary is associated with XXXX .

answer: @entity3


abstract: UNASSIGNED: The incidences of both @entity6 ( @entity6 ) and @entity7 are increasing worldwide. @entity7 is associated with many @entity2 . However, no data are available on @entity2 of unknown primary (CUP), a relatively common, fatal @entity2 for which @entity4 smoking is the only known risk factor. At diagnosis, CUP @entity1 are found in various organs, which has implications for prognosis. We carried out a nationwide study on the association of CUP with @entity6 and @entity7 . 32   600 @entity6 @entity0 and 178   000 @entity7 @entity0 were identified from the national healthcare registers and these were linked to the Swedish @entity2 Registry. Standardized incidence ratios (SIRs) were calculated for CUP from 1997 through 2010 using anyone without @entity3 as a reference. The SIR of CUP in 421 @entity3 @entity0 was 1.71, highest for CUP with liver (2.17) and respiratory system (1.95) @entity1 . The SIR was 2.91 for @entity6 , but with a small number of @entity0 , 1.38 for @entity7 with insulin treatment, and 1.78 for the main group of @entity7 . CUP with liver and respiratory system @entity1 increased for each @entity3 type; however, for @entity7 , CUP with @entity5 also increased. The results provide the first demonstration that CUP is one of the @entity2 associated with @entity3 , with definite evidence on @entity7 . CUP has a poor prognosis, which may be even worse when @entity3 is the underlying comorbidity. A mechanistic question for future work is to determine whether @entity3 promotes primaries that escape detection or their metastatic spread.

title: XXXX of unknown primary is associated with @entity3 .

answer: @entity2


abstract: @entity2 is a histologic diagnosis based on subjective findings. Transcriptional profiles have been used to differentiate normal tissue from disease and could provide a means of identifying @entity0 . The goal of this study was to generate and test transcriptomic profiles that differentiate normal from @entity1 . Comparisons were made between cDNA microarrays derived from normal epithelium and @entity2 . Results were filtered according to standard deviation to retain only highly dysregulated genes. Genes differentially expressed between @entity0 and normal tissue on two-groups t test (P < 0.05, Bonferroni P value adjustment) were further analyzed. Genes were rank ordered in terms of descending fold change. For each comparison ( @entity0 versus normal epithelium), those 5 genes with the greatest positive fold change were grouped in a classifier. Five separate tests were applied to evaluate the discriminatory capacity of each classifier. Genetic classifiers derived comparing normal epithelium with malignant rectal epithelium from pooled stages had a mean sensitivity and specificity of 99.6% and 98.2%, respectively. The classifiers derived from comparing normal and stage I @entity0 had comparable mean sensitivities and specificities (97% and 98%, respectively). Areas under the summary receiver-operator characteristic curves for each classifier were 0.981 and 0.972, respectively. One gene was common to both classifiers. Classifiers were tested in an independent Gene Expression Omnibus-derived dataset. Both classifiers retained their predictive properties. Transcriptomic profiles comprising as few as 5 genes are highly accurate in differentiating normal from adenocarcinomatous rectal epithelium, including early-stage disease.

title: Transcriptomic profiles differentiate normal rectal epithelium and XXXX .

answer: @entity2