abstract: Oligonucleotides offer the potential to manipulate gene expression in targeted cells which might be exploitable for therapeutic benefit. The effects of combining a phosphorothioate oligonucleotide OL(1) @entity2 , which transiently down-regulates @entity2 levels, with an @entity4 , @entity5 , on the growth of wild-type @entity2 WMN gene-expressing @entity1 cells was evaluated. Fluorescent OL(1) @entity2 , was used to demonstrate oligonucleotide uptake and retention by the WMN cells. Uptake was maximal at 24 hours and compared to baseline (0 hours) increasing apoptotic cells were evident in WMN cells treated with OL(1) (1 microM) alone and in combination with @entity5 (0.2 nM) for 24 to 48 hours. In cells treated with OL(1) @entity2 and @entity5 , truncated @entity2 message of a predicted 201 base pair length based on RNAase H cleavage of the OL(1) @entity2 - @entity2 mRNA heteroduplex was detected after 7 hours of incubation. The message for @entity2 was transiently downregulated as detected by RT-PCR analysis at 24 hours, and protein levels transiently reduced at 36 hours, as shown by a quantitative Western blot. Corresponding to these events, the growth of WMN cells ceased after 48 hours in the concurrent presence of OL(1) @entity2 and @entity5 and, the @entity1 cells were dead after 72 hours. No reduction in @entity3 colony forming cell capacity of similarly treated @entity3 progenitor cells harvested from cytokine-mobilized blood by apheresis was observed. Therefore, synergistic @entity0 of @entity5 for @entity1 cells treated with an oligonucleotide targeting @entity2 message was demonstrated at oligonucleotide and @entity5 concentrations which were minimally toxic to @entity3 progenitor cells. This approach offers new opportunities for purging of @entity1 cells from @entity3 harvests and @entity1 therapy.

title: Oligonucleotide enhanced XXXX of @entity5 for @entity1 cells.

answer: @entity0


abstract: Oligonucleotides offer the potential to manipulate gene expression in targeted cells which might be exploitable for therapeutic benefit. The effects of combining a phosphorothioate oligonucleotide OL(1) @entity2 , which transiently down-regulates @entity2 levels, with an @entity4 , @entity5 , on the growth of wild-type @entity2 WMN gene-expressing @entity1 cells was evaluated. Fluorescent OL(1) @entity2 , was used to demonstrate oligonucleotide uptake and retention by the WMN cells. Uptake was maximal at 24 hours and compared to baseline (0 hours) increasing apoptotic cells were evident in WMN cells treated with OL(1) (1 microM) alone and in combination with @entity5 (0.2 nM) for 24 to 48 hours. In cells treated with OL(1) @entity2 and @entity5 , truncated @entity2 message of a predicted 201 base pair length based on RNAase H cleavage of the OL(1) @entity2 - @entity2 mRNA heteroduplex was detected after 7 hours of incubation. The message for @entity2 was transiently downregulated as detected by RT-PCR analysis at 24 hours, and protein levels transiently reduced at 36 hours, as shown by a quantitative Western blot. Corresponding to these events, the growth of WMN cells ceased after 48 hours in the concurrent presence of OL(1) @entity2 and @entity5 and, the @entity1 cells were dead after 72 hours. No reduction in @entity3 colony forming cell capacity of similarly treated @entity3 progenitor cells harvested from cytokine-mobilized blood by apheresis was observed. Therefore, synergistic @entity0 of @entity5 for @entity1 cells treated with an oligonucleotide targeting @entity2 message was demonstrated at oligonucleotide and @entity5 concentrations which were minimally toxic to @entity3 progenitor cells. This approach offers new opportunities for purging of @entity1 cells from @entity3 harvests and @entity1 therapy.

title: Oligonucleotide enhanced @entity0 of @entity5 for XXXX cells.

answer: @entity1


abstract: Oligonucleotides offer the potential to manipulate gene expression in targeted cells which might be exploitable for therapeutic benefit. The effects of combining a phosphorothioate oligonucleotide OL(1) @entity2 , which transiently down-regulates @entity2 levels, with an @entity4 , @entity5 , on the growth of wild-type @entity2 WMN gene-expressing @entity1 cells was evaluated. Fluorescent OL(1) @entity2 , was used to demonstrate oligonucleotide uptake and retention by the WMN cells. Uptake was maximal at 24 hours and compared to baseline (0 hours) increasing apoptotic cells were evident in WMN cells treated with OL(1) (1 microM) alone and in combination with @entity5 (0.2 nM) for 24 to 48 hours. In cells treated with OL(1) @entity2 and @entity5 , truncated @entity2 message of a predicted 201 base pair length based on RNAase H cleavage of the OL(1) @entity2 - @entity2 mRNA heteroduplex was detected after 7 hours of incubation. The message for @entity2 was transiently downregulated as detected by RT-PCR analysis at 24 hours, and protein levels transiently reduced at 36 hours, as shown by a quantitative Western blot. Corresponding to these events, the growth of WMN cells ceased after 48 hours in the concurrent presence of OL(1) @entity2 and @entity5 and, the @entity1 cells were dead after 72 hours. No reduction in @entity3 colony forming cell capacity of similarly treated @entity3 progenitor cells harvested from cytokine-mobilized blood by apheresis was observed. Therefore, synergistic @entity0 of @entity5 for @entity1 cells treated with an oligonucleotide targeting @entity2 message was demonstrated at oligonucleotide and @entity5 concentrations which were minimally toxic to @entity3 progenitor cells. This approach offers new opportunities for purging of @entity1 cells from @entity3 harvests and @entity1 therapy.

title: Oligonucleotide enhanced @entity0 of XXXX for @entity1 cells.

answer: @entity5


abstract: INTRODUCTION: This consensus statement summarizes the proceedings of The Expert Consensus Conference on @entity2 in the Athlete of the North American Society of Pacing and Electrophysiology (NASPE) on detecting, evaluating, and treating athletes with @entity1 that predispose to @entity2 . METHODS AND RESULTS: The @entity0 in the open policy conference were selected by the codirectors ( @entity3 . Estes and Olshansky) based on expertise and contributions to the literature. All @entity0 provided a referenced summary of their presentation. The writing group used the information from all published scientific studies, clinical trials, registries, clinical experience, and expert opinion to make recommendations regarding screening, evaluation, management, eligibility for competition, and a range of other medical, social, and legal issues regarding the recreational and competitive athlete. The codirectors of the symposium synthesized the @entity0 ' reports for this and made revisions according to suggestions of all members of the writing committee. The manuscript was reviewed by four independent reviewers assigned by the NASPE Committee for the Development of Position Statements and NASPE Board of Trustees. CONCLUSION: Despite considerable advances in knowledge regarding the diagnosis, therapy, and mechanisms of @entity2 in the athlete, much remains unknown. Continued basic, clinical, and epidemiologic research is needed. Current screening techniques to detect athletes lack sensitivity and specificity. Evaluation of standardized screening programs with tracking of long-term outcomes is needed. Officials from athletic, academic, medical, and legal institutions need to form strategic partnerships to develop policy related to assessment of risk and assumption of responsibility for athletic activities.

title: Report of the NASPE policy conference on XXXX and the athlete.

answer: @entity2


abstract: A non-heart-beating donor model was considered to examine whether @entity2 hearts from the abattoir could be resuscitated by whole blood reperfusion. For preservation, machine perfusion using University of Wisconsin (UW) solution was compared with storage on ice. Nineteen hearts from abattoir @entity2 , harvested 25 +/- 3 min after exsanguination, were harvested and transported to the laboratory. Controls (n = 7) were immediately reperfused with homologous whole @entity2 blood in an isolated heart model for 60 min with monitoring of @entity1 ( @entity1 ), contractility, and coronary flow. UW solution hearts (UW, n = 6) were perfused for 4 h with 10 degrees C cold UW solution before blood reperfusion. In the cold storage group (CS, n = 6), the organs were stored for an additional 4 h on ice before blood reperfusion. In all hearts, histology was performed after 60 min of blood reperfusion to evaluate @entity0 . All three groups showed significant increases in @entity1 (p <.001), although this functional recovery was earliest in the control group and latest in the UW group. Significant declines were observed for both @entity1 and contractility from the peak values in each group to the end of blood reperfusion. Coronary flow increased steadily over the time course for the UW group, whereas in the control and CS groups flow increased during the first 15 min of blood reperfusion and then decreased. In the UW and CS groups, there were significant positive correlations between coronary flow and @entity1 (p <.001). Microscopic examination revealed no differences between the three groups. Thus, hearts from an abattoir with 25 min of warm ischemic time can be resuscitated. For storage of these organs, continuous machine perfusion with UW solution is superior to cold storage on ice.

title: A non-heart-beating donor model to evaluate functional and morphologic outcomes in resuscitated XXXX hearts.

answer: @entity2


abstract: OBJECTIVE: For over 3 weeks in October 2002, a series of sniper attacks in the Washington, DC, area left 10 @entity0 dead and 3 wounded. This study examined the relationship of distress associated with routine activities and perceived safety to psychological and behavioral responses. METHODS: @entity0 were 1238 residents of the Washington, DC, metropolitan area (aged 18 to 90 years, mean=41.7 years) who completed an Internet survey including the Impact of Event Scale-Revised, @entity0 Health Questionnaire-9, and items pertaining to distress related to routine activities, perceived safety, and @entity2 use. Data were collected at one time point approximately 3 weeks after the first sniper shooting and before apprehension of the suspects. Relationships of distress and perceived safety to post-traumatic stress, @entity3 , and increased @entity2 use were examined by using linear and logistic regression analyses. RESULTS: Approximately 8% of the @entity0 met the symptom criteria for probable post-traumatic @entity1 , 22% reported mild to severe @entity3 , and 4% reported increased @entity2 use during the attacks. Distress related to routine activities and perceived safety were associated with increased post-traumatic stress and @entity3 and @entity2 use. CONCLUSION: Distress and perceived safety are associated with specific routine activities and both contribute to psychological and behavioral responses during a terrorist attack. These findings have implications for targeted information dissemination and risk communication by community leaders. (Disaster Med Public Health Preparedness. 2015;0:1-7).

title: Distress of Routine Activities and Perceived Safety Associated with Post-Traumatic Stress, @entity3 , and XXXX Use: 2002 Washington, DC, Sniper Attacks.

answer: @entity2


abstract: OBJECTIVE: For over 3 weeks in October 2002, a series of sniper attacks in the Washington, DC, area left 10 @entity0 dead and 3 wounded. This study examined the relationship of distress associated with routine activities and perceived safety to psychological and behavioral responses. METHODS: @entity0 were 1238 residents of the Washington, DC, metropolitan area (aged 18 to 90 years, mean=41.7 years) who completed an Internet survey including the Impact of Event Scale-Revised, @entity0 Health Questionnaire-9, and items pertaining to distress related to routine activities, perceived safety, and @entity2 use. Data were collected at one time point approximately 3 weeks after the first sniper shooting and before apprehension of the suspects. Relationships of distress and perceived safety to post-traumatic stress, @entity3 , and increased @entity2 use were examined by using linear and logistic regression analyses. RESULTS: Approximately 8% of the @entity0 met the symptom criteria for probable post-traumatic @entity1 , 22% reported mild to severe @entity3 , and 4% reported increased @entity2 use during the attacks. Distress related to routine activities and perceived safety were associated with increased post-traumatic stress and @entity3 and @entity2 use. CONCLUSION: Distress and perceived safety are associated with specific routine activities and both contribute to psychological and behavioral responses during a terrorist attack. These findings have implications for targeted information dissemination and risk communication by community leaders. (Disaster Med Public Health Preparedness. 2015;0:1-7).

title: Distress of Routine Activities and Perceived Safety Associated with Post-Traumatic Stress, XXXX , and @entity2 Use: 2002 Washington, DC, Sniper Attacks.

answer: @entity3


abstract: UNASSIGNED: Accurate diagnosis of the nature of @entity1 is challenging but more important than ever, due partly to the increasing number of incidental cystic findings in the pancreas. Preliminary data suggest that positron emission tomography/computed tomography using @entity2 ( @entity4 -FDG PET/CT) could have a significant influence on clinical decision making, although its role is still evolving. Our aim was to prospectively compare the accuracy of combined @entity4 -FDG PET/contrast enhanced (ce) CT, multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in differentiating between malignant and benign @entity1 . METHODS: Thirty-one consecutive @entity0 with @entity1 were enrolled for the study. The @entity0 underwent a protocol including @entity4 -FDG PET/ceCT, MDCT and MRI combined with magnetic resonance cholangiopancreatography (MRCP), all of which were evaluated blind. The findings were confirmed macroscopically at operation and/or by histopathological analysis (n = 22), or at follow-up (n = 9). RESULTS: Out of 31 @entity0 , six had malignant and 25 had benign lesions. The diagnostic accuracy of @entity4 -FDG PET/ceCT was 94% compared with 77% and 87% for MDCT (p<0.05) and MRI, respectively. @entity4 -FDG PET/ceCT had a NPV of 100% and a @entity3 of 75% for @entity1 . The maximum standardized uptake value (SUVmax) was significantly higher in malignant (7.4  2.6) than in benign lesions (2.4  0.8) (p<0.05). When the SUVmax was set at 3.6, the sensitivity and specificity was 100% and 88%, respectively. Furthermore, when compared to MDCT and MRI, respectively, the clinical management of five and three @entity0 was altered after @entity4 -FDG PET/ceCT. CONCLUSION: @entity4 -FDG PET/ceCT is an accurate imaging modality for differentiating between benign and malignant @entity1 . We recommend the use of @entity4 -FDG PET/ceCT in the evaluation of diagnostically challenging @entity1 .

title: The diagnostic accuracy study of @entity2 positron emission tomography/computed tomography (FDG-PET/CT), multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the diagnosis of XXXX ; a prospective single center study.

answer: @entity1


abstract: UNASSIGNED: Accurate diagnosis of the nature of @entity1 is challenging but more important than ever, due partly to the increasing number of incidental cystic findings in the pancreas. Preliminary data suggest that positron emission tomography/computed tomography using @entity2 ( @entity4 -FDG PET/CT) could have a significant influence on clinical decision making, although its role is still evolving. Our aim was to prospectively compare the accuracy of combined @entity4 -FDG PET/contrast enhanced (ce) CT, multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in differentiating between malignant and benign @entity1 . METHODS: Thirty-one consecutive @entity0 with @entity1 were enrolled for the study. The @entity0 underwent a protocol including @entity4 -FDG PET/ceCT, MDCT and MRI combined with magnetic resonance cholangiopancreatography (MRCP), all of which were evaluated blind. The findings were confirmed macroscopically at operation and/or by histopathological analysis (n = 22), or at follow-up (n = 9). RESULTS: Out of 31 @entity0 , six had malignant and 25 had benign lesions. The diagnostic accuracy of @entity4 -FDG PET/ceCT was 94% compared with 77% and 87% for MDCT (p<0.05) and MRI, respectively. @entity4 -FDG PET/ceCT had a NPV of 100% and a @entity3 of 75% for @entity1 . The maximum standardized uptake value (SUVmax) was significantly higher in malignant (7.4  2.6) than in benign lesions (2.4  0.8) (p<0.05). When the SUVmax was set at 3.6, the sensitivity and specificity was 100% and 88%, respectively. Furthermore, when compared to MDCT and MRI, respectively, the clinical management of five and three @entity0 was altered after @entity4 -FDG PET/ceCT. CONCLUSION: @entity4 -FDG PET/ceCT is an accurate imaging modality for differentiating between benign and malignant @entity1 . We recommend the use of @entity4 -FDG PET/ceCT in the evaluation of diagnostically challenging @entity1 .

title: The diagnostic accuracy study of XXXX positron emission tomography/computed tomography (FDG-PET/CT), multidetector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the diagnosis of @entity1 ; a prospective single center study.

answer: @entity2


abstract: Previous studies of c-mvc DNA amplification in @entity0 have focused primarily on analysis of @entity9 or its @entity1 cell lines. There are few data about @entity5 DNA amplification in histological types of @entity0 other than @entity9 . Therefore the present study was conducted to investigate @entity5 oncogene amplification in @entity7 . We studied 46 @entity0 specimens for @entity5 DNA amplification (15 @entity4 , 15 @entity6 , 6 @entity2 , and 10 @entity9 ). Polymerase chain reaction, @entity8 DNA labeling, and electrophoresis were utilized to investigate the @entity5 copy number in the @entity0 specimens. The @entity5 copy number of @entity9 ranged from 1.5 to more than 20.0 in @entity4 and @entity6 , and from 6.0 to 12.0 in @entity2 . That of @entity9 ranged from 1.8 to 12.0. The @entity5 copy number of @entity9 was significantly higher than that of @entity9 (Wilcoxon rank sum test, Z=2.06 P=0.040). However, the differences in @entity5 copy number among these four histological types were not statistically significant. Amplification of @entity5 (more than 4 copies) was observed not only in @entity9 but also in nonsmall cell @entity3 at similarly high frequency (12/15 in @entity4 and @entity6 , 6/6 in @entity2 , and 9/10 in @entity9 ).

title: Analysis of @entity5 DNA amplification in XXXX in comparison with small cell lung carcinoma using polymerase chain reaction.

answer: @entity7


abstract: Previous studies of c-mvc DNA amplification in @entity0 have focused primarily on analysis of @entity9 or its @entity1 cell lines. There are few data about @entity5 DNA amplification in histological types of @entity0 other than @entity9 . Therefore the present study was conducted to investigate @entity5 oncogene amplification in @entity7 . We studied 46 @entity0 specimens for @entity5 DNA amplification (15 @entity4 , 15 @entity6 , 6 @entity2 , and 10 @entity9 ). Polymerase chain reaction, @entity8 DNA labeling, and electrophoresis were utilized to investigate the @entity5 copy number in the @entity0 specimens. The @entity5 copy number of @entity9 ranged from 1.5 to more than 20.0 in @entity4 and @entity6 , and from 6.0 to 12.0 in @entity2 . That of @entity9 ranged from 1.8 to 12.0. The @entity5 copy number of @entity9 was significantly higher than that of @entity9 (Wilcoxon rank sum test, Z=2.06 P=0.040). However, the differences in @entity5 copy number among these four histological types were not statistically significant. Amplification of @entity5 (more than 4 copies) was observed not only in @entity9 but also in nonsmall cell @entity3 at similarly high frequency (12/15 in @entity4 and @entity6 , 6/6 in @entity2 , and 9/10 in @entity9 ).

title: Analysis of XXXX DNA amplification in @entity7 in comparison with small cell lung carcinoma using polymerase chain reaction.

answer: @entity5


abstract: The purpose of this trial was to evaluate the feasibility of concurrent @entity7 / @entity4 and conventional thoracic irradiation in locally advanced @entity6 ( @entity6 ). Ambulatory @entity0 with medically inoperable or unresectable stage II-III @entity6 , and performance status 0-2 were eligible. @entity0 were not excluded from this trial if they had lost more than 5% of their body weight during the preceding 3 months, and/or if they had small ipsilateral @entity5 . The initial dose of @entity7 / @entity4 was 110 and 50 mg/m(2), and was escalated through five dose levels. Four cycles of chemotherapy were planned; the first two cycles were given concurrently with radiotherapy (4 weeks apart), followed by two additional cycles (every 3 weeks). Conventional chest radiotherapy to a total dose of 60 Gy (2 Gy per day) was delivered in 6 weeks. Forty-three @entity0 were enrolled of which 38 were evaluable for response. Dose-limiting @entity2 were grade 4 @entity8 (43% of @entity0 ) and grade 3 @entity9 (26% of @entity0 ) during the chemoradiotherapy phase. Grade > or = 2 acute and late @entity3 occurred in 10 and 68% of the @entity0 , respectively. In most @entity0 , prompt symptomatic and radiologic improvement was observed with early @entity1 administration. The volume of lung receiving 15-30 Gy was correlated with late @entity3 . The overall response was 84% with ten complete and 22 partial responses. The median survival was 16.5 months (95% confidence interval, 9.5 to 25) for those @entity0 evaluable for response. After a median follow-up of 70 months, 5 (13%) @entity0 are alive without evidence of disease. The maximum tolerated dose (MTD) of @entity7 and @entity4 with concurrent radiotherapy is at dose level 3 @entity7 (135 mg/m(2)) and @entity4 (75 mg/m(2)). @entity2 , although significant, was manageable in the great majority of the @entity0 . The activity observed with this regimen is particularly noteworthy when considering the advanced nature of these @entity0 , and the fact that @entity0 (N=18) with poor risk factors were included in the study.

title: Concurrent chemoradiation therapy with XXXX and @entity7 for locally advanced @entity6 : long-term follow-up of a phase I trial.

answer: @entity4


abstract: The purpose of this trial was to evaluate the feasibility of concurrent @entity7 / @entity4 and conventional thoracic irradiation in locally advanced @entity6 ( @entity6 ). Ambulatory @entity0 with medically inoperable or unresectable stage II-III @entity6 , and performance status 0-2 were eligible. @entity0 were not excluded from this trial if they had lost more than 5% of their body weight during the preceding 3 months, and/or if they had small ipsilateral @entity5 . The initial dose of @entity7 / @entity4 was 110 and 50 mg/m(2), and was escalated through five dose levels. Four cycles of chemotherapy were planned; the first two cycles were given concurrently with radiotherapy (4 weeks apart), followed by two additional cycles (every 3 weeks). Conventional chest radiotherapy to a total dose of 60 Gy (2 Gy per day) was delivered in 6 weeks. Forty-three @entity0 were enrolled of which 38 were evaluable for response. Dose-limiting @entity2 were grade 4 @entity8 (43% of @entity0 ) and grade 3 @entity9 (26% of @entity0 ) during the chemoradiotherapy phase. Grade > or = 2 acute and late @entity3 occurred in 10 and 68% of the @entity0 , respectively. In most @entity0 , prompt symptomatic and radiologic improvement was observed with early @entity1 administration. The volume of lung receiving 15-30 Gy was correlated with late @entity3 . The overall response was 84% with ten complete and 22 partial responses. The median survival was 16.5 months (95% confidence interval, 9.5 to 25) for those @entity0 evaluable for response. After a median follow-up of 70 months, 5 (13%) @entity0 are alive without evidence of disease. The maximum tolerated dose (MTD) of @entity7 and @entity4 with concurrent radiotherapy is at dose level 3 @entity7 (135 mg/m(2)) and @entity4 (75 mg/m(2)). @entity2 , although significant, was manageable in the great majority of the @entity0 . The activity observed with this regimen is particularly noteworthy when considering the advanced nature of these @entity0 , and the fact that @entity0 (N=18) with poor risk factors were included in the study.

title: Concurrent chemoradiation therapy with @entity4 and @entity7 for locally advanced XXXX : long-term follow-up of a phase I trial.

answer: @entity6


abstract: The purpose of this trial was to evaluate the feasibility of concurrent @entity7 / @entity4 and conventional thoracic irradiation in locally advanced @entity6 ( @entity6 ). Ambulatory @entity0 with medically inoperable or unresectable stage II-III @entity6 , and performance status 0-2 were eligible. @entity0 were not excluded from this trial if they had lost more than 5% of their body weight during the preceding 3 months, and/or if they had small ipsilateral @entity5 . The initial dose of @entity7 / @entity4 was 110 and 50 mg/m(2), and was escalated through five dose levels. Four cycles of chemotherapy were planned; the first two cycles were given concurrently with radiotherapy (4 weeks apart), followed by two additional cycles (every 3 weeks). Conventional chest radiotherapy to a total dose of 60 Gy (2 Gy per day) was delivered in 6 weeks. Forty-three @entity0 were enrolled of which 38 were evaluable for response. Dose-limiting @entity2 were grade 4 @entity8 (43% of @entity0 ) and grade 3 @entity9 (26% of @entity0 ) during the chemoradiotherapy phase. Grade > or = 2 acute and late @entity3 occurred in 10 and 68% of the @entity0 , respectively. In most @entity0 , prompt symptomatic and radiologic improvement was observed with early @entity1 administration. The volume of lung receiving 15-30 Gy was correlated with late @entity3 . The overall response was 84% with ten complete and 22 partial responses. The median survival was 16.5 months (95% confidence interval, 9.5 to 25) for those @entity0 evaluable for response. After a median follow-up of 70 months, 5 (13%) @entity0 are alive without evidence of disease. The maximum tolerated dose (MTD) of @entity7 and @entity4 with concurrent radiotherapy is at dose level 3 @entity7 (135 mg/m(2)) and @entity4 (75 mg/m(2)). @entity2 , although significant, was manageable in the great majority of the @entity0 . The activity observed with this regimen is particularly noteworthy when considering the advanced nature of these @entity0 , and the fact that @entity0 (N=18) with poor risk factors were included in the study.

title: Concurrent chemoradiation therapy with @entity4 and XXXX for locally advanced @entity6 : long-term follow-up of a phase I trial.

answer: @entity7


abstract: BACKGROUND: There remains uncertainty concerning the safety and efficacy of high-frequency oscillatory ventilation as compared with those of conventional ventilation for the respiratory support of very preterm @entity0 . We conducted a multicenter trial to determine whether early intervention with high-frequency oscillatory ventilation reduced mortality and the incidence of @entity2 among newborns with a gestational age of 28 weeks or less. METHODS: We randomly assigned preterm @entity0 with a gestational age of 23 to 28 weeks to either conventional ventilation or high-frequency oscillatory ventilation within one hour after birth. Randomization was stratified according to center and gestational age (23 to 25 weeks or 26 to 28 weeks). RESULTS: A total of 400 @entity0 were assigned to high-frequency oscillatory ventilation, and 397 were assigned to conventional ventilation. The composite primary outcome ( @entity1 or @entity2 , diagnosed at 36 weeks of postmenstrual age) occurred in 66 percent of the @entity0 assigned to receive high-frequency oscillatory ventilation and 68 percent of those in the conventional-ventilation group (relative risk in the group assigned to high-frequency oscillatory ventilation, 0.98; 95 percent confidence interval, 0.89 to 1.08). Similar proportions of @entity0 died or had @entity2 in each gestational-age group. In both treatment groups treatment failure occurred in 10 percent of @entity0 (relative risk in the group assigned to high-frequency oscillatory ventilation, 0.99; 95 percent confidence interval, 0.66 to 1.50). There were no significant differences between the groups in a range of other secondary outcome measures, including serious @entity3 and air leak. CONCLUSIONS: The results obtained with high-frequency oscillatory ventilation and conventional ventilation do not differ significantly in the early treatment of @entity4 in very preterm @entity0 . Assessment of long-term effects will require additional follow-up.

title: High-frequency oscillatory ventilation for the prevention of XXXX of prematurity.

answer: @entity2


abstract: Endovascular surgery for @entity1 ( @entity1 ) has been performed with different commercially available devices since more than 7 years. The technique of implantation even for @entity4 is feasible. Attention is now focused on complications and mid-term results. We present a single center experience over the last 7 years using nine different endografts. 653 @entity0 with AAAs were treated endovascularly (158 tubes, 495 bifurcated) between August 1994 and September 2001. The total mortality rate in the follow-up period (median 37 months) was 6.1 % with a 30-day mortality of 0.76 % and a procedure-related lethality of 1.2 %. Tube endografts showed the highest endoleakage rate (37.3 %) due to secondary shortening, migration and material defects. Endoleakage was diagnosed in 18.2 % of unibody designed stentgrafts versus 28.3 % in modular grafts. Regarding proximal Type I endoleaks suprarenal fixation with uncovered stents seems to be of no further advantage in proximal graft fixation. The conversion rate was 6.6 % (n = 43), @entity4 following endovascular repair occurred in 3 of these @entity0 (0.45 %). Mortality in emergency conversion was 30 % compared to no deaths in elective cases. There was a surprisingly high rate of inadvertent renal @entity3 (9 %) in follow-up CT scans, two times higher in suprarenal fixation (18 %) than in infrarenal position (7.4 %). In conclusion, we observed best results in unibody bifurcated stentgrafts, late failure of first generation endografts (Mintec(R)) and decreasing conversion rates over the last years (learning curve!). The clinical significance of a side @entity2 and related maximal @entity1 diameter remains uncertain. The ideal graft has yet to be found, but improvements in design and implantation techniques evolve rapidly. Good results will be obtained in the future by @entity0 selection and restrictive indications.

title: [Results of XXXX Repair (EVAR)].

answer: @entity1


abstract: During 1993 to 2000 85 @entity0 were treated for a @entity6 . The average age of the @entity0 was 72.4 years (46-90). 71 @entity0 showed an @entity2 and the remaining 14 a suprenal rupture. 76 of 85 cases were @entity2 . All @entity0 were operated upon. A tube graft was required in 43 cases and 31 needed a bifurcated graft. In further two cases an extraanatomical bypass was necessary due to a @entity7 . The operation on 11 @entity0 could not be completed and 21 @entity0 died in hospital during the postoperative period. On the other hand, 53 @entity0 survived the rupture of the @entity3 . The mortality rate was 37.6 %. The early non-surgical complications dominated during the postoperative period. @entity5 , @entity1 and @entity4 were responsible for the mortality rate. It is unforseeable which @entity0 will survive the emergency operation. Therefore it is always appropriate to attempt the reconstruction of an acutely ruptured AAA.

title: [Results and complications of XXXX repair].

answer: @entity6


abstract: BACKGROUND: Narrowband UVB (NB-UVB) phototherapy has been shown to be effective for the treatment of various dermatoses. OBJECTIVE: We evaluated the effect of NB-UVB in the treatment of early stage @entity1 ( @entity1 ). METHODS: The response of 24 @entity0 (12 stage IA, 12 stage IB) with patch stage @entity1 to thrice weekly NB-UVB was assessed. Twelve @entity0 had skin phototypes I-III, and 12 had types IV-VI. Seven @entity0 had hypopigmented @entity1 . Mean follow-up period was 29.0 weeks. RESULTS: Thirteen @entity0 (54.2%) had a complete response (CR), 7 (29.2%) had partial response (PR), and 4 (16.7%) had no response. Specimens from a repeat biopsy in 10 @entity0 with CR showed histologic clearing in 9 of them. Upon discontinuation of treatment, 4 @entity0 with CR relapsed, with a mean time to relapse of 12.5 weeks. CONCLUSION: NB-UVB is a viable, comparably safe, and easily administered alternative in the management of early stage @entity1 .

title: Narrowband UVB phototherapy for early-stage XXXX .

answer: @entity1


abstract: STUDY OBJECTIVE: We determine the frequency of @entity0 presenting without a primary complaint of @entity4 who are admitted with @entity3 ( @entity3 ) and identify factors associated with an increased risk of a presentation without @entity4 . METHODS: This was a retrospective, cross-sectional study over a 5-year period (July 1, 1993, to June 30, 1998) of @entity0 presenting to a large urban, public hospital emergency department who were admitted and determined to have an @entity3 based on International Classification of Diseases, 9th Revision, coding and chart review. Main outcome measures were prevalence of presentation without @entity4 and prevalence of other predefined presentations (ie, @entity9 , @entity6 , @entity2 , @entity8 / @entity1 / @entity5 ) as determined by the primary chief complaint entered on arrival at the @entity10 . We calculated univariate relative risks and multivariate odds ratios (ORs) for presentation without @entity4 in @entity0 , nonwhite ethnic groups, and older age groups. RESULTS: Of the 721 cases of diagnosed @entity3 , 53% (380; 95% confidence interval [CI] 49% to 56%) of @entity0 presented with @entity4 . The frequency of other complaints were @entity9 , 17% (121); @entity6 , 7% (50); @entity8 / @entity1 / @entity5 , 4% (32); @entity2 , 2% (14); and other, 17% (124). The risk of a presentation without @entity4 in a @entity0 with @entity3 increased with age. The characteristic with the highest risk for a presentation without @entity4 in @entity0 with @entity3 was age older than 84 years old (multivariate OR 5.76; 95% CI 3.06 to 10.83). @entity0 were more likely than @entity0 to present without @entity4 (multivariate OR 1.59; 95% CI 1.11 to 2.28). CONCLUSION: Our results demonstrate that @entity0 with @entity3 commonly present to the @entity10 without a primary initial complaint of @entity4 and that the frequency of initial presentations without @entity4 in our urban, public hospital is as high or higher than that reported in the general @entity10 population. Heightened awareness of atypical presentations may affect assessment of @entity0 with @entity3 and provide further focus for research into presentations of @entity7 other than @entity4 .

title: Presenting complaint among @entity0 with XXXX who present to an urban, public hospital emergency department.

answer: @entity3


abstract: STUDY OBJECTIVE: We determine the frequency of @entity0 presenting without a primary complaint of @entity4 who are admitted with @entity3 ( @entity3 ) and identify factors associated with an increased risk of a presentation without @entity4 . METHODS: This was a retrospective, cross-sectional study over a 5-year period (July 1, 1993, to June 30, 1998) of @entity0 presenting to a large urban, public hospital emergency department who were admitted and determined to have an @entity3 based on International Classification of Diseases, 9th Revision, coding and chart review. Main outcome measures were prevalence of presentation without @entity4 and prevalence of other predefined presentations (ie, @entity9 , @entity6 , @entity2 , @entity8 / @entity1 / @entity5 ) as determined by the primary chief complaint entered on arrival at the @entity10 . We calculated univariate relative risks and multivariate odds ratios (ORs) for presentation without @entity4 in @entity0 , nonwhite ethnic groups, and older age groups. RESULTS: Of the 721 cases of diagnosed @entity3 , 53% (380; 95% confidence interval [CI] 49% to 56%) of @entity0 presented with @entity4 . The frequency of other complaints were @entity9 , 17% (121); @entity6 , 7% (50); @entity8 / @entity1 / @entity5 , 4% (32); @entity2 , 2% (14); and other, 17% (124). The risk of a presentation without @entity4 in a @entity0 with @entity3 increased with age. The characteristic with the highest risk for a presentation without @entity4 in @entity0 with @entity3 was age older than 84 years old (multivariate OR 5.76; 95% CI 3.06 to 10.83). @entity0 were more likely than @entity0 to present without @entity4 (multivariate OR 1.59; 95% CI 1.11 to 2.28). CONCLUSION: Our results demonstrate that @entity0 with @entity3 commonly present to the @entity10 without a primary initial complaint of @entity4 and that the frequency of initial presentations without @entity4 in our urban, public hospital is as high or higher than that reported in the general @entity10 population. Heightened awareness of atypical presentations may affect assessment of @entity0 with @entity3 and provide further focus for research into presentations of @entity7 other than @entity4 .

title: Presenting complaint among XXXX with @entity3 who present to an urban, public hospital emergency department.

answer: @entity0


abstract: The metabolic actions of @entity6 ( @entity2 ) were compared in cultured skeletal muscle cells from @entity4 ( @entity4 ) and type 2 @entity0 subjects. @entity3 stimulated @entity1 uptake with comparable sensitivity in @entity4 (EC(50) = 2.0 +/- 0.7 nmol/L) and @entity0 (1.3 +/- 0.4) cells. @entity2 sensitivity for uptake stimulation was similar in @entity4 (EC(50) = 0.30 +/- 0.06 nmol/L) and type 2 cells (0.37 +/- 0.01). In @entity4 cells, @entity3 and @entity2 were equally potent for stimulation of @entity1 uptake and glycogen synthase (GS) activity. However, in @entity0 cells, maximal @entity3 stimulation of both responses was only half of the increases due to @entity2 . Final absolute activities after @entity2 stimulation were still lower in @entity0 cells compared with cells from @entity4 subjects. Hormonal stimulation of Akt phosphorylation exhibited the same behavior as metabolic responses; comparable for @entity3 and @entity2 in @entity4 muscle, while @entity2 was significantly more effective in @entity0 cells. Both @entity3 receptor (IR) binding and receptor protein expression were similar in @entity4 and @entity0 cells. @entity2 binding and receptor protein expression were not significantly different in @entity0 compared with @entity4 cells. The expression of IGF-binding proteins (IGFBP) 3, 5, and 6 were similar in @entity4 and @entity0 cells; @entity5 was slightly, but significantly higher, in @entity0 cells. While @entity3 and @entity2 are equally effective on metabolic responses in @entity4 muscle, @entity0 muscle cells are markedly more resistant to @entity3 than @entity2 . The greater metabolic activity of @entity2 in type 2 @entity0 muscle may provide new insights into the mechanisms of @entity3 resistance in skeletal muscle.

title: @entity3 and @entity3 -like growth factor-1 action on human skeletal muscle: preferential effects of @entity2 in type 2 XXXX subjects.

answer: @entity0


abstract: The metabolic actions of @entity6 ( @entity2 ) were compared in cultured skeletal muscle cells from @entity4 ( @entity4 ) and type 2 @entity0 subjects. @entity3 stimulated @entity1 uptake with comparable sensitivity in @entity4 (EC(50) = 2.0 +/- 0.7 nmol/L) and @entity0 (1.3 +/- 0.4) cells. @entity2 sensitivity for uptake stimulation was similar in @entity4 (EC(50) = 0.30 +/- 0.06 nmol/L) and type 2 cells (0.37 +/- 0.01). In @entity4 cells, @entity3 and @entity2 were equally potent for stimulation of @entity1 uptake and glycogen synthase (GS) activity. However, in @entity0 cells, maximal @entity3 stimulation of both responses was only half of the increases due to @entity2 . Final absolute activities after @entity2 stimulation were still lower in @entity0 cells compared with cells from @entity4 subjects. Hormonal stimulation of Akt phosphorylation exhibited the same behavior as metabolic responses; comparable for @entity3 and @entity2 in @entity4 muscle, while @entity2 was significantly more effective in @entity0 cells. Both @entity3 receptor (IR) binding and receptor protein expression were similar in @entity4 and @entity0 cells. @entity2 binding and receptor protein expression were not significantly different in @entity0 compared with @entity4 cells. The expression of IGF-binding proteins (IGFBP) 3, 5, and 6 were similar in @entity4 and @entity0 cells; @entity5 was slightly, but significantly higher, in @entity0 cells. While @entity3 and @entity2 are equally effective on metabolic responses in @entity4 muscle, @entity0 muscle cells are markedly more resistant to @entity3 than @entity2 . The greater metabolic activity of @entity2 in type 2 @entity0 muscle may provide new insights into the mechanisms of @entity3 resistance in skeletal muscle.

title: @entity3 and @entity3 -like growth factor-1 action on human skeletal muscle: preferential effects of XXXX in type 2 @entity0 subjects.

answer: @entity2


abstract: The metabolic actions of @entity6 ( @entity2 ) were compared in cultured skeletal muscle cells from @entity4 ( @entity4 ) and type 2 @entity0 subjects. @entity3 stimulated @entity1 uptake with comparable sensitivity in @entity4 (EC(50) = 2.0 +/- 0.7 nmol/L) and @entity0 (1.3 +/- 0.4) cells. @entity2 sensitivity for uptake stimulation was similar in @entity4 (EC(50) = 0.30 +/- 0.06 nmol/L) and type 2 cells (0.37 +/- 0.01). In @entity4 cells, @entity3 and @entity2 were equally potent for stimulation of @entity1 uptake and glycogen synthase (GS) activity. However, in @entity0 cells, maximal @entity3 stimulation of both responses was only half of the increases due to @entity2 . Final absolute activities after @entity2 stimulation were still lower in @entity0 cells compared with cells from @entity4 subjects. Hormonal stimulation of Akt phosphorylation exhibited the same behavior as metabolic responses; comparable for @entity3 and @entity2 in @entity4 muscle, while @entity2 was significantly more effective in @entity0 cells. Both @entity3 receptor (IR) binding and receptor protein expression were similar in @entity4 and @entity0 cells. @entity2 binding and receptor protein expression were not significantly different in @entity0 compared with @entity4 cells. The expression of IGF-binding proteins (IGFBP) 3, 5, and 6 were similar in @entity4 and @entity0 cells; @entity5 was slightly, but significantly higher, in @entity0 cells. While @entity3 and @entity2 are equally effective on metabolic responses in @entity4 muscle, @entity0 muscle cells are markedly more resistant to @entity3 than @entity2 . The greater metabolic activity of @entity2 in type 2 @entity0 muscle may provide new insights into the mechanisms of @entity3 resistance in skeletal muscle.

title: XXXX and @entity3 -like growth factor-1 action on human skeletal muscle: preferential effects of @entity2 in type 2 @entity0 subjects.

answer: @entity3


abstract: The metabolic actions of @entity6 ( @entity2 ) were compared in cultured skeletal muscle cells from @entity4 ( @entity4 ) and type 2 @entity0 subjects. @entity3 stimulated @entity1 uptake with comparable sensitivity in @entity4 (EC(50) = 2.0 +/- 0.7 nmol/L) and @entity0 (1.3 +/- 0.4) cells. @entity2 sensitivity for uptake stimulation was similar in @entity4 (EC(50) = 0.30 +/- 0.06 nmol/L) and type 2 cells (0.37 +/- 0.01). In @entity4 cells, @entity3 and @entity2 were equally potent for stimulation of @entity1 uptake and glycogen synthase (GS) activity. However, in @entity0 cells, maximal @entity3 stimulation of both responses was only half of the increases due to @entity2 . Final absolute activities after @entity2 stimulation were still lower in @entity0 cells compared with cells from @entity4 subjects. Hormonal stimulation of Akt phosphorylation exhibited the same behavior as metabolic responses; comparable for @entity3 and @entity2 in @entity4 muscle, while @entity2 was significantly more effective in @entity0 cells. Both @entity3 receptor (IR) binding and receptor protein expression were similar in @entity4 and @entity0 cells. @entity2 binding and receptor protein expression were not significantly different in @entity0 compared with @entity4 cells. The expression of IGF-binding proteins (IGFBP) 3, 5, and 6 were similar in @entity4 and @entity0 cells; @entity5 was slightly, but significantly higher, in @entity0 cells. While @entity3 and @entity2 are equally effective on metabolic responses in @entity4 muscle, @entity0 muscle cells are markedly more resistant to @entity3 than @entity2 . The greater metabolic activity of @entity2 in type 2 @entity0 muscle may provide new insights into the mechanisms of @entity3 resistance in skeletal muscle.

title: @entity3 and XXXX -like growth factor-1 action on human skeletal muscle: preferential effects of @entity2 in type 2 @entity0 subjects.

answer: @entity3


abstract: Portuguese type @entity3 is a dominantly inherited @entity3 caused by a mutant transthyretin ( @entity4 ). Because @entity4 is produced mainly by the liver, liver transplantation (LT) abolishes production of the amyloidogenic variant @entity4 . To date, the procedure appears to halt the progress of the disease. However, long-term outcome is unknown. The aim of the present study is to evaluate the survival of our initial group of unselected liver transplant recipients with @entity2 . Seventy @entity0 , 51 transplant recipients and a control group of 19 nontransplantation @entity0 , with disease onset before the age of 55 years were included on the study. Transplant recipients were divided into two categories: (1) early series, with @entity0 followed up for 5 years or longer, and (2) new series, with @entity0 followed up for 1 to 5 years. Nonparametric statistical methods were used. Binary regression analyses were performed by stepwise logistic regression and Cox proportional hazard regression. Survival analysis was performed using Kaplan-Meier analysis, the Cox-Mantel test. Survival analyses and Cox proportional hazard regression analysis were performed from disease onset, not from LT. Significantly decreased survival was noted for transplant recipients with a modified body mass index (mBMI) less than 600 compared with the control group (P < .05). A significant difference in survival also was observed between transplant recipients with an mBMI greater than 600 at the time of LT compared with those with an mBMI less than 600 (P < .02). mBMI and age at LT had a significant impact on survival; whereas late deaths were related to age at LT, early deaths were related to mBMI. The cumulative 10-year survival rate after disease onset was 94% in the new series, with one @entity1 (< 6 months) after LT, compared with a 78% survival rate and eight early deaths in the early series (P = .1).

title: Long-term follow-up of survival of liver transplant recipients with XXXX (Portuguese type).

answer: @entity3


abstract: BACKGROUND: Non @entity2 is an important health problem with a very high prevalence in the general population, being its pathophysiology still unclear and its association with @entity3 highly controversial. Many trials have been carried out assessing the effects of different drugs on the symptoms in dyspeptic @entity0 , being one of the most common the use of H2 antagonist, even though the results have shown conflicting as far as efficacy is concerned. The goal of the present study is to determine the efficacy of @entity5 (administered in three different regimens) as compared to placebo in relieving the symptoms of non @entity2 .METHODS: @entity0 with chronic non @entity2 were included and were selected by random in four groups; group I received @entity5 40 mg before breakfast, placebo before dinner and at bedtime; group II received @entity5 20 mg before breakfast and dinner and placebo at bedtime; group III received @entity5 40 mg at bedtime, placebo before breakfast and dinner; group IV received placebo before breakfast, dinner and at bedtime. A four week treatment period was completed. Endoscopy, measure of the gastric juice pH, and biopsy (including study for H.p) was done at the beginning of the study, at week 4 and at week 8. The @entity0 was asked for a global assessment of improvement in the overall symptoms of @entity4 at the end of weeks 1,4 and 8.RESULTS: Forty-eight @entity0 (12 @entity0 and 36 @entity0 ) participated in the study. There was not statistical difference between any of the four schemes of treatment and the effect over the @entity1 and the symptoms during the study. Nevertheless there was a highly statistically difference (p<0.01) of the well being of the @entity0 with all the groups of treatment received. There was a significant difference (p<0.05) between the pH of the groups II, III, IV, being the pH at fourth week, the one with a high mean value. There was not statistical difference in the pH value between @entity0 that improve its symptoms and those that not H.p. presence was the same along the study in the group that showed improvement of @entity1 and related symptoms and the group that did not improve. There was no significant changes in the histological pattern and the grade of inflammatory activity in relation to symptoms improvement. During the study there was not any clinical laboratory adverse experience.CONCLUSIONS: Non of the three schemes with @entity5 used in this trial has proven to have any therapeutical benefit in non @entity2 compared to placebo, even though @entity0 improved their symptoms in all the four groups. It seems that gastric juice does not play a rol in the genesis of non @entity2 . In this study, nor the presence of H.p. neither inflammatory activity are associated with the symptoms of non @entity2 . More studies carefully designed are required not only to understand pathophysiological mechanism, also to identify effective treatments for this frequent entity.

title: [ XXXX VERSUS PLACEBO IN NON ULCER DYSPEPSIA TREATMENT]

answer: @entity5


abstract: UNASSIGNED: Several non-invasive two-dimensional techniques with different lateral resolution and measurable depth range have proved to be useful in assessing and quantifying morphological changes in skin ageing. Among these, only in vivo microscopy techniques permit histometric measurements in vivo. Qualitative and quantitative assessment of chronological (intrinsic) age-related (IAR) morphological changes of epidermis, dermo-epidermal junction (DEJ), @entity1 ( @entity1 ), papillary- @entity3 junction and @entity3 ( @entity3 ) have been performed by high-definition optical coherence tomography in real time 3-D. @entity2 -OCT images were taken at the internal site of the right upper arm. Qualitative @entity2 -OCT IAR descriptors were reported at skin surface, at epidermal layer, DEJ, @entity1 and upper @entity3 . Quantitative evaluation of age-related compaction and backscattered intensity or brightness of different skin layers was performed by using the plugin plot z-axis profile of ImageJ(  ) software permitting intensity assessment of @entity2 -OCT (DICOM) images (3-D images). Analysis was in blind from all clinical information. Sixty, fair-skinned (Fitzpatrick types I-III) healthy females were analysed retrospectively in this study. The subjects belonged to three age groups: twenty in group I aged 20-39, twenty in group II aged 40-59 and twenty in group III aged 60-79. Only intrinsic ageing in @entity0 has been studied. Significant age-related qualitative and quantitative differences could be noticed. IAR changes in dermal matrix fibers morphology/organisation and in microvasculature were observed. The brightness and compaction of the different skin layers increased significantly with intrinsic skin ageing. The depth of visibility of fibers in @entity3 increased significantly in the older age group. In conclusion, @entity2 -OCT allows 3-D in vivo and real time qualitative and quantitative assessment of chronological (intrinsic) age-related morphological skin changes at high resolution from skin surface to a depth of the superficial @entity3 .

title: High-definition optical coherence tomography intrinsic skin ageing assessment in XXXX : a pilot study.

answer: @entity0


abstract: @entity0 with @entity6 usually present with @entity10 , microscopic @entity8 , @entity1 , and @entity2 ; 50% develop @entity5 within a few years. There is no known effective therapy for @entity6 . We describe three @entity0 with biopsy-proven @entity6 , in whom pathognomonic fibrillar deposits of 20-nm diameter were seen by electron microscopy. All @entity0 had @entity10 and normal renal function at the time of diagnosis. They were treated initially with @entity4 , 1 mg/kg body weight, then tapered individually according to the clinical course. Additional therapy consisted of an angiotensin-converting enzyme inhibitor and diuretics. @entity7 disappeared in two of three @entity0 after 9 and 12 months of therapy. In one @entity0 , @entity7 was reduced from 7.49 mg/mg @entity9 to 0.63 mg/mg @entity9 after 6 months of treatment. The kidney function remained normal in all three cases. Two @entity0 are now free of @entity3 therapy for 9 and 6 months. They show no signs of recurrence of @entity1 and have normal renal function without significant @entity7 . @entity3 therapy in @entity0 with biopsy-proven @entity6 , starting with @entity4 , 1 mg/kg body weight, and tapered individually according to the clinical course, is a promising strategy. Early start of treatment in @entity0 with preserved renal function seems to be crucial for a favorable outcome.

title: XXXX : early diagnosis associated with @entity3 responsiveness.

answer: @entity6


abstract: @entity0 with @entity6 usually present with @entity10 , microscopic @entity8 , @entity1 , and @entity2 ; 50% develop @entity5 within a few years. There is no known effective therapy for @entity6 . We describe three @entity0 with biopsy-proven @entity6 , in whom pathognomonic fibrillar deposits of 20-nm diameter were seen by electron microscopy. All @entity0 had @entity10 and normal renal function at the time of diagnosis. They were treated initially with @entity4 , 1 mg/kg body weight, then tapered individually according to the clinical course. Additional therapy consisted of an angiotensin-converting enzyme inhibitor and diuretics. @entity7 disappeared in two of three @entity0 after 9 and 12 months of therapy. In one @entity0 , @entity7 was reduced from 7.49 mg/mg @entity9 to 0.63 mg/mg @entity9 after 6 months of treatment. The kidney function remained normal in all three cases. Two @entity0 are now free of @entity3 therapy for 9 and 6 months. They show no signs of recurrence of @entity1 and have normal renal function without significant @entity7 . @entity3 therapy in @entity0 with biopsy-proven @entity6 , starting with @entity4 , 1 mg/kg body weight, and tapered individually according to the clinical course, is a promising strategy. Early start of treatment in @entity0 with preserved renal function seems to be crucial for a favorable outcome.

title: @entity6 : early diagnosis associated with XXXX responsiveness.

answer: @entity3


abstract: BACKGROUND: At least 14% of @entity3 ( @entity3 ) @entity0 develop @entity1 ( @entity1 ). The pathophysiology behind these behaviors and the impact of deep brain stimulation in a real-life setting remain unclear. OBJECTIVES: We prospectively examined the impact of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on @entity1 in @entity3 @entity0 , as well as the relationship between impaired sensorimotor gaiting and impulsivity. METHODS: @entity0 undergoing bilateral STN-DBS were assessed for @entity1 preoperatively and 1-year postoperatively using a validated questionnaire (QUIP-RS). A subset of @entity0 completed the Balloon Analogue Risk Task (BART) and auditory prepulse inhibition (PPI) testing. RESULTS: Analysis revealed 12 @entity0 had an improvement in score assessing @entity1 ('good responders'; p = 0.006) while 4 had a worse or stable score ('poor responders'; p > 0.05). Good responders further exemplified a significant decrease in @entity2 (p = 0.005) and binge eating (p = 0.01). Impaired PPI responses also significantly correlated with impulsivity in BART (r = -0.72, p = 0.044). DISCUSSION: Following bilateral STN-DBS, 75% of our cohort had a reduction in @entity1 , thus suggesting deep brain stimulation effectively manages @entity1 in @entity3 . The role of impaired PPI in predisposition to @entity1 in @entity3 warrants further investigation.    2015 S. Karger AG, Basel.

title: The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in XXXX @entity0 .

answer: @entity3


abstract: BACKGROUND: At least 14% of @entity3 ( @entity3 ) @entity0 develop @entity1 ( @entity1 ). The pathophysiology behind these behaviors and the impact of deep brain stimulation in a real-life setting remain unclear. OBJECTIVES: We prospectively examined the impact of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on @entity1 in @entity3 @entity0 , as well as the relationship between impaired sensorimotor gaiting and impulsivity. METHODS: @entity0 undergoing bilateral STN-DBS were assessed for @entity1 preoperatively and 1-year postoperatively using a validated questionnaire (QUIP-RS). A subset of @entity0 completed the Balloon Analogue Risk Task (BART) and auditory prepulse inhibition (PPI) testing. RESULTS: Analysis revealed 12 @entity0 had an improvement in score assessing @entity1 ('good responders'; p = 0.006) while 4 had a worse or stable score ('poor responders'; p > 0.05). Good responders further exemplified a significant decrease in @entity2 (p = 0.005) and binge eating (p = 0.01). Impaired PPI responses also significantly correlated with impulsivity in BART (r = -0.72, p = 0.044). DISCUSSION: Following bilateral STN-DBS, 75% of our cohort had a reduction in @entity1 , thus suggesting deep brain stimulation effectively manages @entity1 in @entity3 . The role of impaired PPI in predisposition to @entity1 in @entity3 warrants further investigation.    2015 S. Karger AG, Basel.

title: The Influence of Bilateral Subthalamic Nucleus Deep Brain Stimulation on Impulsivity and Prepulse Inhibition in @entity3 XXXX .

answer: @entity0


abstract: BACKGROUND: @entity4 ( @entity4 ) has been used for antiadhesion formation along with wound healing in various surgical fields. OBJECTIVE: The aim is to assess the efficacy of @entity4 implantation in the prevention of @entity2 and adhesions after conventional, open, total thyroidectomy. MATERIALS AND METHODS: Forty-four @entity0 with @entity3 undergoing thyroidectomy were randomly assigned to the study ( @entity4 implantation) or control group (without @entity4 ). Global photographic assessment, Vancouver scar scale (VSS), objective scar assessment, and swallowing impairment index were assessed at baseline, immediately after surgery, and at 1 and 2 months after surgery. RESULTS: Nineteen control and 20 study group @entity0 completed the study. The mean VSS score of the study group was significantly lower than the controls at both 1 month (3.06    1.25 vs 4.41    1.54, respectively) and 2 months (2.76    1.56 vs 4.35    1.58, respectively) after surgery. Scar quality measures (mean melanin and erythema indexes) were significantly lower in the study group compared with controls. Study group @entity0 had significantly lower swallowing impairment scores than controls. The mean postoperative hospitalization of both groups was not significantly different. CONCLUSION: @entity4 -assisted implants appear to improve post-thyroidectomy scar and @entity1 without delays in operation time.

title: Preventive Effect of XXXX Acellular Dermal Matrix on Post-thyroidectomy Scars and Adhesions: A Randomized, Double-Blinded, Controlled Trial.

answer: @entity0


abstract: Thus far, orthopedic research lacks a suitable animal model of @entity2 . In OVX @entity4 , 6 months of @entity1 exposure reduced bone density and mechanical competence. Bone properties and bone formation did not recover for another 6 months. Therefore, @entity1 -treated OVX @entity4 may serve as a large animal model for @entity7 bone. INTRODUCTION: The purpose of this study was to explore the effects of glucocorticoid treatment on cancellous bone density, microarchitecture, biomechanics, and formation of new bone. MATERIALS AND METHODS: Sixteen ovariectomized merino @entity4 received either a 6-month glucocorticoid treatment ( @entity3 ; 0.45 mg/kg @entity5 ) or were left untreated (control). Cancellous bone biopsy specimens from the tibia were harvested 6 months after ovariectomy. After 12 months, the animals were killed, and biopsy specimens were obtained from the contralateral tibia and the lumbar spine. All biopsy specimens were scanned for apparent bone mineral density by peripheral quantitative computed tomography (pQCT) and tested mechanically in uniaxial compression. Three-dimensional bone reconstructions were obtained by microcomputed tomography. Formation of new bone was analyzed using histologies of the femoral condyles. RESULTS: After 6 months, mineral density (-19%) and mechanical competence (-45%) were reduced by glucocorticoid treatment (p < 0.1). BV/TV (-21%; p < 0.01) and trabecular thickness (-20%; p = 0.01) declined, whereas BS/BV increased (24%; p = 0.01). After 12 months, mineral density (-33%) and mechanical properties (-55%) were reduced even more profoundly (p < 0.05). Also, the structural parameters (BS/BV and Tb.Th.) still seemed to be affected by glucocorticoid treatment (p < 0.05). New bone formation, assessed by measurement of osteoid surface, was markedly reduced (-63%, p < 0.1) by glucocorticoid treatment. The differences between groups were generally more pronounced at the tibia and the femur than at the spine. CONCLUSION: The effects of short-term high-dose @entity1 administration on bone mineral in this animal model were comparable with those observed in @entity0 after long-term corticoid treatment. Reduction in bone quality and bone formation rate persisted after the cessation of @entity1 administration. Glucocorticoid treatment of ovariectomized @entity4 may therefore serve as a large animal model for @entity1 -induced @entity6 .

title: Glucocorticoid treatment of ovariectomized XXXX affects mineral density, structure, and mechanical properties of cancellous bone.

answer: @entity4


abstract: BACKGROUND: The disruption of the hepatocyte tight junctions observed in @entity1 suggests altered permeability of the blood-bile barrier. In this study the role of @entity1 and increased biliary pressure on the translocation of bacteria from biliary tract to bloodstream and lymphatic system were evaluated. MATERIALS AND METHODS: @entity0 underwent distal bile duct ligation (BDL, n = 33) for two weeks or a sham celiotomy (n = 21). Seventeen of the 33 BDL @entity0 underwent subsequent biliary decompression by a choledochojejunostomy (CJ). Two weeks after the final operation, a laparotomy was performed again and the CBD, the thoracic duct, and the caval vein were canulated. Next, a suspension containing 10(8) @entity3 /ml was retrogradely infused in the CBD for 5 min at 5 or 20 cm @entity4 above the secretory biliary pressure. RESULTS: A higher biliary infusion pressure resulted in a significant increase of cfu @entity3 per milliliter of blood in all the three groups (Sham, BDL, CJ). BDL @entity0 showed significantly more bacterial translocation to the bloodstream than the shams. After biliary decompression, translocation normalized to the control levels. At 5 cm @entity4 infusion pressure only one lymph culture was positive (CJ group). At 20 cm @entity4 overpressure, nine lymph cultures were @entity3 positive (P = 0.03). These were found mainly in groups with a nonobstructed bile duct (Sham and CJ 40% vs BDL 10%). CONCLUSION: Translocation of bacteria from biliary tract to bloodstream increased at higher intrabiliary pressures. Longstanding bile duct obstruction was an independent determinant for @entity2 . Bacterial translocation to the lymphatic system did not parallel translocation to the bloodstream, although in the nonobstructed biliary tract, increased bacterial translocation to the lymphatic system was pressure related.

title: Bacterial translocation from the biliary tract to blood and lymph in XXXX with obstructive jaundice.

answer: @entity0


abstract: UNASSIGNED: By creating the Visible Burrow System (VBS) @entity9 Blanchard found a way to study the interaction of genetics, physiology, environment, and adaptive significance in a model with @entity5 . The VBS changed the way we think about @entity0 and @entity2 by allowing the mechanisms which control them to be observed in a dynamic setting. Critically, Blanchard used the VBS and other models to show how behavioral systems like defense are dependent upon context and behavioral elements unique to the individual. Inspired by the VBS, we developed a @entity3 ( @entity3 ) to further explore the multifaceted dynamics of the stress response with a @entity1 . Like the VBS, the @entity3 is a naturalistic model built upon risk-assessment and defensive behavior, but with a choice of response: escape or submission to a large conspecific aggressor. The @entity0 of novelty during the first escape must be weighed against fear of the aggressor, and a decision must be made. Both outcomes are adaptively significant, evidenced by a 50/50 split in outcome across several study systems. By manipulating the variables of the @entity3 , we show that a gradient of @entity0 exists that spans the contextual settings of escaping an open field, escaping from aggression, and submitting to aggression. These findings correspond with increasing levels of @entity6 and increasing levels of @entity8 and @entity4 in the central amygdala as the context changes. Whereas some anxiolytics were able to reduce the latency to escape for some animals, only with the potent anxiolytic drug @entity10 (CRF1R-blocker) and the anxiogenic drug @entity7 (a2 antagonist) were we able to reverse the outcome for a substantial proportion of individuals. Our findings promote a novel method for modeling @entity0 , offering a distinction between low-and-high levels, and accounting for individual variability. The translational value of the VBS is immeasurable, and it guided us and many other researchers to seek potential clinical solutions through a deeper understanding of regional neurochemistry and gene expression in concert with an ecological behavioral model.

title: Nuance and behavioral cogency: How the Visible Burrow System inspired the Stress-Alternatives Model and conceptualization of the continuum of XXXX .

answer: @entity0


abstract: OBJECTIVE: To study @entity2 ( @entity2 ), i.e. @entity2 without the sensation of vertigo, in @entity0 with @entity4 ( @entity4 ). MATERIAL AND METHODS: The neuro-otological and neuro-radiological records of 179 @entity0 clinically diagnosed as having @entity4 (91 males, 88 females; age range 20-89 years) and 48 @entity0 diagnosed as having @entity3 (15 males, 33 females; age range 21-80 years) were reviewed. Subjects underwent caloric tests using cold water (20 degrees C) in a totally dark room. Immediately after each test session, subjects were asked if they had experienced spinning or moving sensations during the test. Maximum slow phase eye velocities (SPEVs) were measured using electronystagmography. RESULTS: Among @entity0 with @entity3 , all @entity0 with SPEVs > 15 degrees/s experienced spinning or moving sensations during testing. Among the 179 @entity0 with @entity4 , 21 (39 sides) showed maximum SPEVs > 15 degrees/s without spinning or moving sensations. In particular, 8 @entity0 (10 sides) had maximum SPEVs > 25 degrees/s without spinning or moving sensations. Common lesions in the cerebral cortex could not be detected using either MRI or single-photon emission CT. CONCLUSION: @entity0 with @entity4 may also have @entity2 , which may be attributable to @entity1 in the ascending pathways to the vestibular cortex.

title: XXXX in @entity4 .

answer: @entity2


abstract: OBJECTIVE: To study @entity2 ( @entity2 ), i.e. @entity2 without the sensation of vertigo, in @entity0 with @entity4 ( @entity4 ). MATERIAL AND METHODS: The neuro-otological and neuro-radiological records of 179 @entity0 clinically diagnosed as having @entity4 (91 males, 88 females; age range 20-89 years) and 48 @entity0 diagnosed as having @entity3 (15 males, 33 females; age range 21-80 years) were reviewed. Subjects underwent caloric tests using cold water (20 degrees C) in a totally dark room. Immediately after each test session, subjects were asked if they had experienced spinning or moving sensations during the test. Maximum slow phase eye velocities (SPEVs) were measured using electronystagmography. RESULTS: Among @entity0 with @entity3 , all @entity0 with SPEVs > 15 degrees/s experienced spinning or moving sensations during testing. Among the 179 @entity0 with @entity4 , 21 (39 sides) showed maximum SPEVs > 15 degrees/s without spinning or moving sensations. In particular, 8 @entity0 (10 sides) had maximum SPEVs > 25 degrees/s without spinning or moving sensations. Common lesions in the cerebral cortex could not be detected using either MRI or single-photon emission CT. CONCLUSION: @entity0 with @entity4 may also have @entity2 , which may be attributable to @entity1 in the ascending pathways to the vestibular cortex.

title: @entity2 in XXXX .

answer: @entity4


abstract: BACKGROUND: Combined liver-kidney transplantation is the definitive treatment for @entity3 caused by @entity10 ( @entity9 ). The infantile form is characterized by @entity2 early in life, advanced systemic @entity8 , and a formidable mortality rate. Although others have reported on overall results of transplantation for @entity9 covering a wide age spectrum, none has specifically addressed the high-risk infantile form of the disease. METHODS: Six @entity0 with @entity9 underwent simultaneous liver-kidney transplantation at our center between May 1994 and August 1998. Diagnosis was made at 5.2+/-3.3 months of age, they were on dialysis for 11.8+/-2.3 months, and they underwent transplantation at 14.8+/-3.0 months of age when they weighed 10.6+/-1.7 kg. RESULTS: At a mean follow-up of 6.4+/-1.7 years (range, 3.9-8.1 years), we report 100% @entity0 and kidney allograft survival. There were no cases of @entity7 . Long-term kidney allograft function remained stable in all patients, with serum @entity5 values of less than 1.1 mg/dL and a mean creatinine clearance of 99 mL/ @entity4 .73 m2 at follow-up. Those who received combined hemodialysis and peritoneal dialysis pretransplant had lower posttransplant urinary oxalate values than those receiving peritoneal dialysis alone. There was improvement in growth and @entity6 and mental developmental scores after transplantation. CONCLUSIONS: Combined liver-kidney transplantation for the infantile presentation of @entity9 is associated with excellent outcome when the approach includes early diagnosis and early combined transplantation, aggressive pretransplant dialysis, and avoidance of posttransplant @entity1 .

title: One hundred percent @entity0 and kidney allograft survival with simultaneous liver and kidney transplantation in @entity0 with primary XXXX : a single-center experience.

answer: @entity8


abstract: BACKGROUND: Combined liver-kidney transplantation is the definitive treatment for @entity3 caused by @entity10 ( @entity9 ). The infantile form is characterized by @entity2 early in life, advanced systemic @entity8 , and a formidable mortality rate. Although others have reported on overall results of transplantation for @entity9 covering a wide age spectrum, none has specifically addressed the high-risk infantile form of the disease. METHODS: Six @entity0 with @entity9 underwent simultaneous liver-kidney transplantation at our center between May 1994 and August 1998. Diagnosis was made at 5.2+/-3.3 months of age, they were on dialysis for 11.8+/-2.3 months, and they underwent transplantation at 14.8+/-3.0 months of age when they weighed 10.6+/-1.7 kg. RESULTS: At a mean follow-up of 6.4+/-1.7 years (range, 3.9-8.1 years), we report 100% @entity0 and kidney allograft survival. There were no cases of @entity7 . Long-term kidney allograft function remained stable in all patients, with serum @entity5 values of less than 1.1 mg/dL and a mean creatinine clearance of 99 mL/ @entity4 .73 m2 at follow-up. Those who received combined hemodialysis and peritoneal dialysis pretransplant had lower posttransplant urinary oxalate values than those receiving peritoneal dialysis alone. There was improvement in growth and @entity6 and mental developmental scores after transplantation. CONCLUSIONS: Combined liver-kidney transplantation for the infantile presentation of @entity9 is associated with excellent outcome when the approach includes early diagnosis and early combined transplantation, aggressive pretransplant dialysis, and avoidance of posttransplant @entity1 .

title: One hundred percent XXXX and kidney allograft survival with simultaneous liver and kidney transplantation in @entity0 with primary @entity8 : a single-center experience.

answer: @entity0


abstract: BACKGROUND: Combined liver-kidney transplantation is the definitive treatment for @entity3 caused by @entity10 ( @entity9 ). The infantile form is characterized by @entity2 early in life, advanced systemic @entity8 , and a formidable mortality rate. Although others have reported on overall results of transplantation for @entity9 covering a wide age spectrum, none has specifically addressed the high-risk infantile form of the disease. METHODS: Six @entity0 with @entity9 underwent simultaneous liver-kidney transplantation at our center between May 1994 and August 1998. Diagnosis was made at 5.2+/-3.3 months of age, they were on dialysis for 11.8+/-2.3 months, and they underwent transplantation at 14.8+/-3.0 months of age when they weighed 10.6+/-1.7 kg. RESULTS: At a mean follow-up of 6.4+/-1.7 years (range, 3.9-8.1 years), we report 100% @entity0 and kidney allograft survival. There were no cases of @entity7 . Long-term kidney allograft function remained stable in all patients, with serum @entity5 values of less than 1.1 mg/dL and a mean creatinine clearance of 99 mL/ @entity4 .73 m2 at follow-up. Those who received combined hemodialysis and peritoneal dialysis pretransplant had lower posttransplant urinary oxalate values than those receiving peritoneal dialysis alone. There was improvement in growth and @entity6 and mental developmental scores after transplantation. CONCLUSIONS: Combined liver-kidney transplantation for the infantile presentation of @entity9 is associated with excellent outcome when the approach includes early diagnosis and early combined transplantation, aggressive pretransplant dialysis, and avoidance of posttransplant @entity1 .

title: One hundred percent @entity0 and kidney allograft survival with simultaneous liver and kidney transplantation in XXXX with primary @entity8 : a single-center experience.

answer: @entity0


abstract: INTRODUCTION: We conducted a phase IV randomized, double-blind, placebo-controlled, pilot clinical trial to investigate the safety and efficacy of oral @entity2 together with local phototherapy in @entity0 with @entity1 . MATERIALS AND METHODS: @entity0 with moderate to severe @entity1 received Curcuma extract orally with real visible light phototherapy (VLRT) or simulated visible light phototherapy (VLST) in the experimental area, while the rest of the body surface was treated with ultraviolet A (UVA) radiation. The endpoints were the number of responders and the temporal course of the response. The secondary outcomes were related to safety and adverse events. RESULTS: Twenty-one @entity0 were included in the study. In the intention-to-treat analysis, no @entity0 included in the VLRT group showed "moderate" or "severe" plaques after the treatment, in contrast to the @entity0 included in the VSLT group (p<0.01). Parallelisms in the evolution of @entity3 , BSA, and PASI scores were observed in the two groups following the treatment. At the end of the study period, 76% of all @entity0 showed a response in the BSA exposed to UVA. Lesions on the experimental area showed a response in 81% of the @entity0 in the VLRT group and 30% of the @entity0 in the VLST group. There were no study-related adverse events that necessitated @entity0 withdrawal. CONCLUSION: The results suggested that moderate to severe @entity1 should  show a therapeutic response to orally administered Curcuma if activated with visible light phototherapy, a new therapeutic method that would be safer for @entity0 than existing treatments.

title: Effects of Curcuma extract and visible light on adults with XXXX .

answer: @entity1


abstract: BACKGROUND: @entity0 remains a major health problem worldwide, and is becoming increasingly resistant to traditional drug treatments. For instance, @entity6 ( @entity8 ) is beneficial for the treatment of @entity0 . However, its wide application often leads to drug resistance in clinic practice, which results in treatment failure. @entity13 ( @entity12 ), a polyprenylated @entity11 isolated from the traditional medicine gamboge, has been reported to effectively inhibit the survival and proliferation of @entity2 cells. Its effects on @entity8 resistance have not yet been reported in @entity0 . In this study, we examined the ability of @entity12 to modulate @entity8 resiatance and the molecular mechanisms underlying this process using a cell based in vitro system. METHODS: An @entity3 assay was used to evaluate the inhibitory effect of the drugs on the growth of MCF-7 and MCF-7/ @entity8 cell lines. The effects of drugs on apoptosis were detected using @entity9 APC/7-AAD double staining. The expression of apoptosis-related proteins and the proteins in the @entity7 / @entity10 / @entity5 pathway were evaluated by Western blot analysis. RESULTS: In the MCF-7/ @entity8 cell lines, the IC50 (half maximal inhibitory concentration) of the group that received combined treatment with @entity12 and @entity8 was significantly lower than that in the @entity8 group, and this value decreased with an increasing concentration of @entity12 . In parallel, @entity12 treatment increased the chemosensitivity of @entity0 cells to @entity8 . The cell apoptosis and cell cycle anaysis indicated that the anti-proliferative effect of @entity12 is in virtue of increased G0/G1 arrest and potentiated apoptosis. When combined with @entity12 in MCF-7/ @entity8 cell lines, the expression levels of the @entity2 suppressor gene @entity7 (phosphatase and tensin homolog deleted on chromosome ten) and the apoptosis-related proteins @entity4 and capsese-9 were significantly increased, while the expression of phosphorylated @entity5 was decreased. CONCLUSIONS: Our study has indicated a potential role for @entity12 to increase the chemosensitivity of @entity0 cells to @entity8 . This modulatory role was mediated by suppression of the @entity7 / @entity10 / @entity5 pathway that led to apoptosis in MCF-7/ @entity8 cells. This work suggests that @entity12 may be used as a regulatory agent for treating @entity8 resistance in @entity0 @entity1 .

title: XXXX alters chemosensitivity of @entity0 cells to @entity6 .

answer: @entity13


abstract: BACKGROUND: @entity0 remains a major health problem worldwide, and is becoming increasingly resistant to traditional drug treatments. For instance, @entity6 ( @entity8 ) is beneficial for the treatment of @entity0 . However, its wide application often leads to drug resistance in clinic practice, which results in treatment failure. @entity13 ( @entity12 ), a polyprenylated @entity11 isolated from the traditional medicine gamboge, has been reported to effectively inhibit the survival and proliferation of @entity2 cells. Its effects on @entity8 resistance have not yet been reported in @entity0 . In this study, we examined the ability of @entity12 to modulate @entity8 resiatance and the molecular mechanisms underlying this process using a cell based in vitro system. METHODS: An @entity3 assay was used to evaluate the inhibitory effect of the drugs on the growth of MCF-7 and MCF-7/ @entity8 cell lines. The effects of drugs on apoptosis were detected using @entity9 APC/7-AAD double staining. The expression of apoptosis-related proteins and the proteins in the @entity7 / @entity10 / @entity5 pathway were evaluated by Western blot analysis. RESULTS: In the MCF-7/ @entity8 cell lines, the IC50 (half maximal inhibitory concentration) of the group that received combined treatment with @entity12 and @entity8 was significantly lower than that in the @entity8 group, and this value decreased with an increasing concentration of @entity12 . In parallel, @entity12 treatment increased the chemosensitivity of @entity0 cells to @entity8 . The cell apoptosis and cell cycle anaysis indicated that the anti-proliferative effect of @entity12 is in virtue of increased G0/G1 arrest and potentiated apoptosis. When combined with @entity12 in MCF-7/ @entity8 cell lines, the expression levels of the @entity2 suppressor gene @entity7 (phosphatase and tensin homolog deleted on chromosome ten) and the apoptosis-related proteins @entity4 and capsese-9 were significantly increased, while the expression of phosphorylated @entity5 was decreased. CONCLUSIONS: Our study has indicated a potential role for @entity12 to increase the chemosensitivity of @entity0 cells to @entity8 . This modulatory role was mediated by suppression of the @entity7 / @entity10 / @entity5 pathway that led to apoptosis in MCF-7/ @entity8 cells. This work suggests that @entity12 may be used as a regulatory agent for treating @entity8 resistance in @entity0 @entity1 .

title: @entity13 alters chemosensitivity of XXXX cells to @entity6 .

answer: @entity0


abstract: BACKGROUND: @entity0 remains a major health problem worldwide, and is becoming increasingly resistant to traditional drug treatments. For instance, @entity6 ( @entity8 ) is beneficial for the treatment of @entity0 . However, its wide application often leads to drug resistance in clinic practice, which results in treatment failure. @entity13 ( @entity12 ), a polyprenylated @entity11 isolated from the traditional medicine gamboge, has been reported to effectively inhibit the survival and proliferation of @entity2 cells. Its effects on @entity8 resistance have not yet been reported in @entity0 . In this study, we examined the ability of @entity12 to modulate @entity8 resiatance and the molecular mechanisms underlying this process using a cell based in vitro system. METHODS: An @entity3 assay was used to evaluate the inhibitory effect of the drugs on the growth of MCF-7 and MCF-7/ @entity8 cell lines. The effects of drugs on apoptosis were detected using @entity9 APC/7-AAD double staining. The expression of apoptosis-related proteins and the proteins in the @entity7 / @entity10 / @entity5 pathway were evaluated by Western blot analysis. RESULTS: In the MCF-7/ @entity8 cell lines, the IC50 (half maximal inhibitory concentration) of the group that received combined treatment with @entity12 and @entity8 was significantly lower than that in the @entity8 group, and this value decreased with an increasing concentration of @entity12 . In parallel, @entity12 treatment increased the chemosensitivity of @entity0 cells to @entity8 . The cell apoptosis and cell cycle anaysis indicated that the anti-proliferative effect of @entity12 is in virtue of increased G0/G1 arrest and potentiated apoptosis. When combined with @entity12 in MCF-7/ @entity8 cell lines, the expression levels of the @entity2 suppressor gene @entity7 (phosphatase and tensin homolog deleted on chromosome ten) and the apoptosis-related proteins @entity4 and capsese-9 were significantly increased, while the expression of phosphorylated @entity5 was decreased. CONCLUSIONS: Our study has indicated a potential role for @entity12 to increase the chemosensitivity of @entity0 cells to @entity8 . This modulatory role was mediated by suppression of the @entity7 / @entity10 / @entity5 pathway that led to apoptosis in MCF-7/ @entity8 cells. This work suggests that @entity12 may be used as a regulatory agent for treating @entity8 resistance in @entity0 @entity1 .

title: @entity13 alters chemosensitivity of @entity0 cells to XXXX .

answer: @entity6


abstract: OBJECTIVE: To prospectively validate a previously reported scoring system for identifying the near-term @entity0 at risk for the multiple organ system sequelae of acute perinatal @entity6 . STUDY DESIGN: Prospective observational study. SETTING: Three Denver teaching hospitals, each providing comprehensive obstetric care. SUBJECTS: Newborn @entity0 of 36 weeks or more gestation. INTERVENTION: None. STATISTICAL ANALYSIS: Chi-squared analysis with Fisher's exact test. OUTCOME: Scores consisting of graded abnormalities in fetal heart rate monitoring, umbilical arterial base deficit, and 5-minute Apgar score were calculated by the research nurse after admission of the @entity0 to the nursery (range of possible scores, 0 to 9). A second nurse, blinded to these data, prospectively followed the newborn's hospital course for multiple organ system morbidity. RESULTS: Three thousand two hundred thirty-eight newborns were studied; 366 required neonatal intensive care unit admission. Eleven newborns had a score > or = 6 (mean umbilical artery pH = 6.98, base deficit = 17.1 mEq/L). Morbidities in these 11 newborns included @entity2 (2), @entity7 (5), respiratory distress (9), @entity3 (7), @entity1 (9), @entity9 / @entity8 (4), and @entity4 or disseminated @entity5 (3). The odds ratio (OR) and 95% confidence interval (CI) for newborns admitted to the neonatal intensive care unit with a score > or = 6 for having multiple organ system morbidity, defined as three or more affected organ systems, was 38.5 (95% CI, 9.2 to 127.8). The scoring system showed a stronger relationship with multiple organ system morbidity than did isolated individual indicators commonly used to identify @entity6 calculated on the same subjects: for those with pH < 7.00, @entity10 (95% CI, 6.4 to 94.1); base deficit > or = 10 mEq/L, OR 4.5 (95% CI, 1.9 to 10.3), and 5-minute Apgar score < or = 3, OR 7.4 (95% CI, 1.3 to 38.1). CONCLUSION: This scoring system, encompassing both immediate intrapartum and postpartum measures and acid-base status proximate to the time of delivery, is useful for rapidly identifying the term and near-term newborn at risk for multiple organ system morbidity after acute perinatal @entity6 .

title: Prospective validation of a scoring system for predicting neonatal morbidity after acute perinatal XXXX .

answer: @entity6


abstract: A 61-year-old @entity0 with right @entity1 underwent right lower lobectomy. He suffered from @entity2 , which was treated with thoracic drainage. After disappearance of air leakage, a drainage tube was removed. Forty days later, severe @entity3 , cough and fever were observed. Chest computed tomography showed enlarged thoracic cavity around the bronchial stump. Bronchoscopical examination revealed complete dehiscence of the bronchial stump. Because thoracic cavity was localized and located dorsal to the bronchial stump, a fenestration surgery was difficult. We placed a nasal airway from the dorsal to directly thoracic cavity, followed by disappearance of the symptoms. @entity4 around the bronchial stump was gradually decreased and a nasal airway was successfully removed. Because a nasal airway was soft enough to keep supine position, we chose it as a drainage tube. Thoracic drainage using nasal airway may be a suitable therapeutic approach for localized small thoracic cavity.

title: [Thoracic Drainage Using Nasal Airway for XXXX ].

answer: @entity2


abstract: From 1994 to 2001 @entity3 was fulfilled for 19 @entity0 aged from 4 to 28 (mean 11.0+/-7.0) with @entity4 . Early outcomes were satisfactory in all cases. Catheterization showed 10 mm Hg decrease in systolic pressure gradient (SPG). Long-term results (from 6 months to 8 years, mean 3.0+/-2.5) were evaluated with transthoracic EchoCG, Doppler ultrasound, duplex scanning of iliofemoral segment and CT-angiography with 3D reconstruction. Surgical outcomes were considered good when SPG did not exceed 20 mm Hg for Doppler ultrasound and 25 mm Hg for Doppler EchoCG. In the study group there was statistically significant decrease in arterial pressure in right upper limb and SPG (measured with both Doppler EchoCG and Doppler ultrasonography) and rise of ankle-brachial index. Beneficial hemodynamic effect was detected in 15 from 19 @entity0 (79%). Recoarctation has developed in 4 (21%) @entity0 , in 1 (5.3%) case it was combined with true posttraumatic aortic @entity2 . Three @entity0 underwent open surgical intervention with uneventful postoperative period. @entity1 of thoracic aorta has developed in 1 @entity0 (5.3%), non-progressive intimal dissection - in another one (5.3%), 2 @entity0 (10.5%) experienced ipsilateral 40-60% stenosis of right external iliac and femoral arteries. Thus good long-term outcomes of @entity3 in @entity0 with @entity4 were achieved in 79% cases. @entity0 after @entity3 must be assessed regularly with non-invasive diagnostic methods such as Doppler ultrasonography, Doppler EchoCG, CT-angiography.

title: [Long-term outcomes of @entity3 for XXXX ].

answer: @entity4


abstract: From 1994 to 2001 @entity3 was fulfilled for 19 @entity0 aged from 4 to 28 (mean 11.0+/-7.0) with @entity4 . Early outcomes were satisfactory in all cases. Catheterization showed 10 mm Hg decrease in systolic pressure gradient (SPG). Long-term results (from 6 months to 8 years, mean 3.0+/-2.5) were evaluated with transthoracic EchoCG, Doppler ultrasound, duplex scanning of iliofemoral segment and CT-angiography with 3D reconstruction. Surgical outcomes were considered good when SPG did not exceed 20 mm Hg for Doppler ultrasound and 25 mm Hg for Doppler EchoCG. In the study group there was statistically significant decrease in arterial pressure in right upper limb and SPG (measured with both Doppler EchoCG and Doppler ultrasonography) and rise of ankle-brachial index. Beneficial hemodynamic effect was detected in 15 from 19 @entity0 (79%). Recoarctation has developed in 4 (21%) @entity0 , in 1 (5.3%) case it was combined with true posttraumatic aortic @entity2 . Three @entity0 underwent open surgical intervention with uneventful postoperative period. @entity1 of thoracic aorta has developed in 1 @entity0 (5.3%), non-progressive intimal dissection - in another one (5.3%), 2 @entity0 (10.5%) experienced ipsilateral 40-60% stenosis of right external iliac and femoral arteries. Thus good long-term outcomes of @entity3 in @entity0 with @entity4 were achieved in 79% cases. @entity0 after @entity3 must be assessed regularly with non-invasive diagnostic methods such as Doppler ultrasonography, Doppler EchoCG, CT-angiography.

title: [Long-term outcomes of XXXX for @entity4 ].

answer: @entity3


abstract: Asthma in pregnancy has been associated with maternal and fetal morbidity and mortality. This study examines the relations of @entity6 in pregnancy, its severity and its treatment to the labor process, maternal and fetal parameters. Hundred and one consecutive @entity7 @entity0 , who gave birth to single babies between November 1993 and November 1994 at the Soroka Medical Center were studied. A group of 77 nonasthmatic @entity0 , matched for age and ethnic origin, who gave birth to single babies during the same period served as controls. A larger percentage of @entity7 @entity0 suffered from @entity8 than in the control group (p < 0.001). Severe @entity6 was associated with a higher rate of @entity3 than milder @entity6 (p = 0.01). The incidence of smoking was higher among @entity7 @entity0 than among controls (p = 0.037). No association was found between socioeconomic status and smoking or @entity3 . No association was found between maternal @entity6 or maternal use of corticosteroids and the following: maternal @entity2 , maternal @entity1 , low birth weight (< 2,500 g), @entity9 (< 37 weeks), adequacy of weight to gestational age and Apgar scores. Three @entity0 with @entity10 were born to @entity7 mothers. When the presentation of the fetus was not cephalic, all the @entity7 @entity0 were delivered by cesarean section, versus only 60% in the control group (p = 0.08). Labor was induced with @entity5 more often in the @entity6 group than in the control group (p = 0.07). We conclude that the labor and neonatal outcome in pregnant @entity7 @entity0 treated medically is good, even when @entity6 is severe and when the @entity0 is treated with @entity4 . There is, however, a relation between @entity6 in pregnancy, especially if severe, and predisposition to @entity3 .

title: Influence of XXXX in pregnancy on labor and the newborn.

answer: @entity6


abstract: BACKGROUND: Therapeutic interventions in the insulin-like growth factor receptor ( @entity3 ) pathway were expected to provide clinical benefits; however, @entity3 @entity4 kinase inhibitors (TKIs) have shown limited antitumor efficacy, and the mechanisms conveying resistance to these agents remain elusive. METHODS: The expression and activation of the @entity3 and @entity5 were assessed via the analysis of a publicly available dataset, as well as immunohistochemistry, Western blotting, RT-PCR, and in vitro kinase assays. The efficacy of @entity3 TKIs alone or in combination with @entity5 inhibitors was analyzed using @entity2 assays, colony formation assays, flow cytometric analysis, and xenograft @entity1 models. RESULTS: The co-activation of @entity3 and @entity5 was observed in multiple @entity0 NSCLC cell lines as well as in a tissue microarray (n   =   353). The @entity3 and @entity5 proteins mutually phosphorylate on their autophosphorylation sites. In high-pSrc-expressing NSCLC cells, @entity6 treatment initially inactivated the @entity3 pathway but led a @entity5 -dependent reactivation of downstream effectors. In low-pSrc-expressing NSCLC cells, @entity6 treatment decreased the turnover of the @entity3 and @entity5 proteins, ultimately amplifying the reciprocal co-activation of @entity3 and @entity5 . Co-targeting @entity3 and @entity5 significantly suppressed the proliferation and @entity1 growth of both high-pSrc-expressing and low-pSrc-expressing NSCLC cells in vitro and in vivo and the growth of @entity0 -derived tissues in vivo. CONCLUSIONS: Reciprocal activation between @entity5 and @entity3 occurs in NSCLC. @entity5 causes @entity3 TKI resistance by acting as a key downstream modulator of the cross-talk between multiple membrane receptors. Targeting @entity5 is a clinically applicable strategy to overcome resistance to @entity3 TKIs.

title: Targeting the insulin-like growth factor receptor and XXXX signaling network for the treatment of non-small cell lung cancer.

answer: @entity5


abstract: INTRODUCTION: @entity3 ( @entity3 ) tend to occur in Asian @entity0 with prolonged @entity5 exposure. Hip geometry is thought to contribute to the risk of @entity3 formation. We examined the hip structural geometry parameters in Asian female chronic @entity5 users who sustained an @entity3 and compared them to chronic @entity5 users who did not sustain any @entity3 (NFF) and @entity5 - @entity4  ve @entity0 who sustained an @entity3 ( @entity3 ). MATERIALS _ METHODS: Thirty-one @entity0 with AFFs were gender and age-matched to 31 @entity0 with NFFs and 49 @entity0 with OFFs. The Hip Structural Analysis parameters analyzed were @entity1 ( @entity1 ), cross-sectional area (CSA; a metric of resistance to axial compression), section modulus (SM; a metric of resistance to tensile loads), @entity2 ( @entity2 ; mean thickness of the femoral cortices), buckling ratio (BR; an index of likelihood of local buckling), and neck shaft angle (NSA; the angle between the neck and shaft axes). The regions analyzed were three cross-sections measured at the narrowest femoral neck diameter, the intertrochanteric area, and the proximal femoral shaft. One-way ANOVA with Bonferroni adjustment for multiple comparisons was used to compare parameters between the three @entity0 groups, with statistical significance defined as p<0.05. RESULTS: There were no statistical differences in parameters between @entity0 with AFFs and @entity0 with NFFs at all measured regions. @entity0 with AFFs and NFFs had statistically higher @entity1 , CSA, @entity2 , SM values and lower BR values at the @entity6 and IT regions than @entity0 with OFFs. Additionally, @entity0 with NFFs had statistically higher SM values at the IT region than @entity0 with OFFs, while @entity0 with AFFs had statistically higher @entity1 , CSA, and @entity2 values at the FS region. All other measured parameters were not statistically different between the groups. CONCLUSIONS: Chronic @entity5 users with and without AFFs had similar femoral structural geometries. Unlike in other populations, varus neck shaft angles were not found to be associated with AFFs in Asian female chronic @entity5 users. Thus, bone cross-sectional geometry is not likely to be associated with AFFs in Asian female chronic @entity5 users. Hip Structural Analysis does not show an increased predilection for tensile failure in AFFs.

title: Bone cross-sectional geometry is not associated with atypical @entity3 in Asian female chronic XXXX users.

answer: @entity5