abstract: Eleven cases of high-energy industrial @entity2 treated between 1980 and 1984 were retrospectively reviewed. The dominant extremity was affected in nine. Six @entity0 sustained @entity3 and/or dislocations, and three of these @entity0 required fasciotomies for clinical signs of impending compartment syndromes. All @entity3 /dislocations, with the exception of a @entity3 , @entity6 of a thumb interphalangeal joint, and a fractured coronoid process of the ulna, required open reduction with internal fixation. Three @entity0 required split-thickness skin grafting for extensive @entity4 . Two @entity0 required immediate amputation. Late sequelae included prolonged @entity1 , nutritional depletion, @entity8 formation of the superficial branch of the radial nerve, late @entity5 , and partial @entity9 . Industrial @entity2 continue to be an occupational hazard associated with more severe crushing @entity2 than the low-energy wringer washer injuries first described by MacCollum (11). Attention must be paid to the treatment of crushed skin, muscle, and nerves, @entity3 stabilization, nutritional support, and occupational therapy. Concurrent monitoring for signs of a developing @entity7 and complications of @entity10 is essential.

title: High-energy XXXX to the upper extremity.

answer: @entity2


abstract: @entity1 was diagnosed in nine members of a kindred of three generations. This study investigated why these @entity0 were asymptomatic and without @entity4 , in contrast to the common presentation of @entity1 . In the @entity9 subjects, serum @entity2 level was 7.4 +/- 0.8 mg/dl (mean +/- SD) and ionized serum @entity2 level was 3.48 +/- 0.21 mg/dl. Immunoreactive parathyroid hormone values were inappropriately low. Injection of @entity6 in one @entity0 lowered ionized @entity2 levels, but immunoreactive parathyroid hormone values did not rise. Serum levels of @entity8 and other @entity3 metabolites were normal or elevated and substantially higher than in other @entity1 states. The normally observed positive correlation between the fasting urinary @entity2 / @entity5 ratio and serum @entity8 that reflects the dependence of net bone resorption on @entity8 was upheld in @entity1 @entity0 . It is proposed that the subjects with @entity10 in this kindred had moderate asymptomatic @entity7 without @entity4 because normal or elevated serum @entity8 levels enhanced intestinal @entity2 absorption. This may represent one point in the spectrum of @entity1 . Alternately, both the moderate degree of @entity7 and the normal serum calcitriol values could have been related to mild, partial @entity1 , which could have been inherited in this kindred.

title: Moderate @entity7 due to normal serum @entity8 levels in an asymptomatic kindred with XXXX .

answer: @entity10


abstract: @entity1 was diagnosed in nine members of a kindred of three generations. This study investigated why these @entity0 were asymptomatic and without @entity4 , in contrast to the common presentation of @entity1 . In the @entity9 subjects, serum @entity2 level was 7.4 +/- 0.8 mg/dl (mean +/- SD) and ionized serum @entity2 level was 3.48 +/- 0.21 mg/dl. Immunoreactive parathyroid hormone values were inappropriately low. Injection of @entity6 in one @entity0 lowered ionized @entity2 levels, but immunoreactive parathyroid hormone values did not rise. Serum levels of @entity8 and other @entity3 metabolites were normal or elevated and substantially higher than in other @entity1 states. The normally observed positive correlation between the fasting urinary @entity2 / @entity5 ratio and serum @entity8 that reflects the dependence of net bone resorption on @entity8 was upheld in @entity1 @entity0 . It is proposed that the subjects with @entity10 in this kindred had moderate asymptomatic @entity7 without @entity4 because normal or elevated serum @entity8 levels enhanced intestinal @entity2 absorption. This may represent one point in the spectrum of @entity1 . Alternately, both the moderate degree of @entity7 and the normal serum calcitriol values could have been related to mild, partial @entity1 , which could have been inherited in this kindred.

title: Moderate XXXX due to normal serum @entity8 levels in an asymptomatic kindred with @entity10 .

answer: @entity7


abstract: @entity1 was diagnosed in nine members of a kindred of three generations. This study investigated why these @entity0 were asymptomatic and without @entity4 , in contrast to the common presentation of @entity1 . In the @entity9 subjects, serum @entity2 level was 7.4 +/- 0.8 mg/dl (mean +/- SD) and ionized serum @entity2 level was 3.48 +/- 0.21 mg/dl. Immunoreactive parathyroid hormone values were inappropriately low. Injection of @entity6 in one @entity0 lowered ionized @entity2 levels, but immunoreactive parathyroid hormone values did not rise. Serum levels of @entity8 and other @entity3 metabolites were normal or elevated and substantially higher than in other @entity1 states. The normally observed positive correlation between the fasting urinary @entity2 / @entity5 ratio and serum @entity8 that reflects the dependence of net bone resorption on @entity8 was upheld in @entity1 @entity0 . It is proposed that the subjects with @entity10 in this kindred had moderate asymptomatic @entity7 without @entity4 because normal or elevated serum @entity8 levels enhanced intestinal @entity2 absorption. This may represent one point in the spectrum of @entity1 . Alternately, both the moderate degree of @entity7 and the normal serum calcitriol values could have been related to mild, partial @entity1 , which could have been inherited in this kindred.

title: Moderate @entity7 due to normal serum XXXX levels in an asymptomatic kindred with @entity10 .

answer: @entity8


abstract: OBJECTIVE: To examine microcystic inner nuclear layer (INL) changes in @entity6 and to determine associated factors. DESIGN: Retrospective, cross-sectional, observational study. METHODS: Two hundred seventeen eyes of 133 @entity0 with @entity4 ( @entity4 ), 41 eyes of 32 @entity0 with @entity5 and 181 normal eyes of 117 subjects were ultimately included. @entity3 were examined with infrared fundus images and with 19 vertical spectral domain optical coherence tomography (SD-OCT) images in the macular area. RESULTS: Microcystic INL changes were observed in 6.0% of eyes with @entity4 , but none of the normal eyes or eyes with @entity5 showed microcystic INL changes. The proportion of eyes with advanced @entity5 was significantly larger (P = 0.013) in eyes with @entity1 than without. The @entity2 ( @entity8 ) slope was also significantly worse (P = 0.027) in eyes with @entity1 . No significant differences were observed in age, sex, refraction, axial length, intraocular pressure, or @entity8 value between eyes with and without @entity3 . In several cases, @entity3 occurred along with @entity2 . The retinal nerve fiber layer (RNFL) thickness (P = 0.013) and @entity7 ( @entity7 ) + inner plexiform layer thickness (P = 0.023) were significantly lower in areas with @entity1 than without. The INL was also significantly thicker (P = 0.002) in areas with @entity1 . CONCLUSIONS: @entity3 in @entity6 are closely associated with RNFL and @entity7 thinning and correlated with worse @entity8 slope. These INL lesions may indicate focal and progressive damage in @entity5 .

title: Microcystic Inner Nuclear Layer Changes and Retinal Nerve Fiber Layer Defects in Eyes with XXXX .

answer: @entity5


abstract: Twenty-eight @entity0 with @entity2 were treated with combined chemotherapy-radiotherapy employing a unique protocol. Four cycles of @entity7 and @entity12 alternated with four cycles of concurrent @entity9 , whole abdominal radiotherapy, and intraperitoneal @entity11 . The entire treatment program lasted six months. Clinical complete responses were seen in 50% of the @entity0 with an overall response rate of 61%. Pathologic complete response (PCR) confirmed at second look surgery occurred in 18% of the group (5 @entity0 ). Median survival of the entire group was 15.2 months with all PCR's alive NED. This outcome was no different than our previous experience with combination chemotherapy alone. @entity3 seen included @entity10 , @entity8 , @entity5 , @entity6 , and @entity4 . However, these side effects were manageable. Two non- @entity1 deaths occurred. This study demonstrates the feasibility of combining drug and radiation therapy concurrently in the treatment of @entity2 ; further research is needed to explore different sequencing and dose levels that could improve the outcome.

title: The treatment of @entity2 with a combination of chemotherapy, radiotherapy, and radiosensitizer: report of a pilot study from the National XXXX Institute.

answer: @entity1


abstract: Twenty-eight @entity0 with @entity2 were treated with combined chemotherapy-radiotherapy employing a unique protocol. Four cycles of @entity7 and @entity12 alternated with four cycles of concurrent @entity9 , whole abdominal radiotherapy, and intraperitoneal @entity11 . The entire treatment program lasted six months. Clinical complete responses were seen in 50% of the @entity0 with an overall response rate of 61%. Pathologic complete response (PCR) confirmed at second look surgery occurred in 18% of the group (5 @entity0 ). Median survival of the entire group was 15.2 months with all PCR's alive NED. This outcome was no different than our previous experience with combination chemotherapy alone. @entity3 seen included @entity10 , @entity8 , @entity5 , @entity6 , and @entity4 . However, these side effects were manageable. Two non- @entity1 deaths occurred. This study demonstrates the feasibility of combining drug and radiation therapy concurrently in the treatment of @entity2 ; further research is needed to explore different sequencing and dose levels that could improve the outcome.

title: The treatment of XXXX with a combination of chemotherapy, radiotherapy, and radiosensitizer: report of a pilot study from the National @entity1 Institute.

answer: @entity2


abstract: BACKGROUND: Incontinence is a common problem faced by family caregivers that is recognized as a major burden and predictor of institutionalization. However, few studies have evaluated the experiences of family caregivers caring for @entity1 survivors with @entity2 . PURPOSE: To describe experiences of caregivers managing @entity2 in @entity1 survivors. DESIGN: This qualitative descriptive study employed a grounded-theory approach. METHODS: Semi-structured in-depth interviews with ten family caregivers of @entity1 survivors with @entity2 were conducted during 2011. Audiotaped interviews were transcribed and analyzed using content analysis. FINDINGS: Data analysis identified four themes: chaos, hypervigilance, exhaustion, and creating a new life. There were nine related subcategories: fluster, dirtiness, urgency, fear of potential health-hazard, physically demanding and time-consuming, mentally draining, financial burden, learning by doing, and attitude adjustment. Together, these described a process of struggling to cope with the care of @entity1 survivors with urinary/fecal @entity2 . Of the four categories, "creating a new life" developed gradually over time to orient caregivers to their new life, while the other three categories occurred in a chronological order. CONCLUSION: The research highlighted unique caring experiences of family caregivers of @entity1 @entity0 , which focused solely on the ' @entity2 issue'. Understanding these experiences may help nurses provide better support and resources for family caregivers when caring for @entity1 survivors with @entity2 .

title: A Qualitative Study of Family Caregiver Experiences of Managing Incontinence in XXXX Survivors.

answer: @entity1


abstract: A systematic analysis of the cellular components of @entity2 (i.e., goblet cells with or without brush border cells and Paneth cells) was performed in endoscopic gastric biopsies from 984 @entity0 without @entity1 ; 359 Swedish and 625 Japanese @entity0 . The Japanese @entity0 , matched for age and sex, had twice as much @entity2 as the Swedes. The frequency of goblet cells and columnar cells with brush (absorptive) border increased with increasing age in both ethnic groups. Complete @entity2 (i.e. the presence of at least two or all three cellular components) was twice as frequent in the Japanese. This may reflect differences in the environment (including food habits) of the gastric mucosa in the two populations. Structural mucosal changes (i.e. pseudo-villus formations) were found more than twice as often in the Japanese. Since pseudo-villus changes occurred as often as goblet cells and brush border cells in both groups, it is suggested that the above-mentioned mucosal structural change should be considered for inclusion among the histological criteria of @entity2 of the stomach. Incomplete @entity2 (i.e. the occurrence of goblet cells without the other cellular components) occurred in similar proportions in the two populations. The present findings support the theory that incomplete @entity2 may be a para- rather than a preneoplastic phenomenon.

title: Intestinal metaplasia of the stomach in Swedish and Japanese XXXX without ulcers or carcinoma.

answer: @entity0


abstract: PURPOSE: @entity3 ( @entity3 ) has been demonstrated to reduce mortality and morbidity and thereby improve the prognosis of @entity0 undergoing acute @entity5 (AMIs). However, this procedure paradoxically increases the initial damage as the result of a condition known as ' @entity2 '. Oxidative stress may contribute to the mechanism of this injury. The goal of the present study was to ascertain whether high plasma @entity8 levels could ameliorate the reperfusion injuries that occur after the successful restoration of blood flow. METHODS: @entity0 from three clinical centers of the public health system were included in the study. The groups were formed by either-sex @entity0 with a diagnosis of ST-segment elevation @entity5 with an indication for primary @entity3 . Only the @entity0 who presented with their first @entity5 were enrolled. @entity8 was administered through an infusion given prior to the restoration of the coronary flow, which was then followed by oral treatment with @entity6 (500   mg/12   hours) plus @entity1 (400   IU/day) for 84 days. The left ventricular ejection fraction (LVEF) was determined by using cardiac magnetic resonance on days 6 and 84 following the onset of the reperfusion. In addition, the microvascular function was assessed by an angiographic evaluation using the Thrombolysis In @entity5 (TIMI) myocardial perfusion grade (TMPG). The results were grouped according to the plasma @entity8 concentration achieved immediately following the onset of reperfusion into either the HA group (high @entity8 , >1   mmol/l) or the LA group (low @entity8 , <1   mmol/l). The biochemical parameters were analyzed throughout the protocol. RESULTS: The LVEF of the HA group was significantly higher than that of the LA group, values on day 84 in the HA group were 33% higher than those of the LA group. The amelioration of the LVEF was accompanied by an improvement in the @entity4 , after @entity3 , 95% of the @entity0 in the HA group achieved a TMPG of 2-3, in the LA group only 79% of @entity0 showed a TMPG of 2-3. CONCLUSIONS: These data are consistent with the protective effect of high plasma levels of @entity8 against the oxidative challenge caused by @entity7 in @entity0 subjected to @entity3 following an AMI. Further studies are needed to elucidate the mechanism accounting for this beneficial antioxidant effect.

title: Amelioration of persistent left ventricular function impairment through increased plasma XXXX levels following @entity5 .

answer: @entity8


abstract: PURPOSE: @entity3 ( @entity3 ) has been demonstrated to reduce mortality and morbidity and thereby improve the prognosis of @entity0 undergoing acute @entity5 (AMIs). However, this procedure paradoxically increases the initial damage as the result of a condition known as ' @entity2 '. Oxidative stress may contribute to the mechanism of this injury. The goal of the present study was to ascertain whether high plasma @entity8 levels could ameliorate the reperfusion injuries that occur after the successful restoration of blood flow. METHODS: @entity0 from three clinical centers of the public health system were included in the study. The groups were formed by either-sex @entity0 with a diagnosis of ST-segment elevation @entity5 with an indication for primary @entity3 . Only the @entity0 who presented with their first @entity5 were enrolled. @entity8 was administered through an infusion given prior to the restoration of the coronary flow, which was then followed by oral treatment with @entity6 (500   mg/12   hours) plus @entity1 (400   IU/day) for 84 days. The left ventricular ejection fraction (LVEF) was determined by using cardiac magnetic resonance on days 6 and 84 following the onset of the reperfusion. In addition, the microvascular function was assessed by an angiographic evaluation using the Thrombolysis In @entity5 (TIMI) myocardial perfusion grade (TMPG). The results were grouped according to the plasma @entity8 concentration achieved immediately following the onset of reperfusion into either the HA group (high @entity8 , >1   mmol/l) or the LA group (low @entity8 , <1   mmol/l). The biochemical parameters were analyzed throughout the protocol. RESULTS: The LVEF of the HA group was significantly higher than that of the LA group, values on day 84 in the HA group were 33% higher than those of the LA group. The amelioration of the LVEF was accompanied by an improvement in the @entity4 , after @entity3 , 95% of the @entity0 in the HA group achieved a TMPG of 2-3, in the LA group only 79% of @entity0 showed a TMPG of 2-3. CONCLUSIONS: These data are consistent with the protective effect of high plasma levels of @entity8 against the oxidative challenge caused by @entity7 in @entity0 subjected to @entity3 following an AMI. Further studies are needed to elucidate the mechanism accounting for this beneficial antioxidant effect.

title: Amelioration of persistent left ventricular function impairment through increased plasma @entity8 levels following XXXX .

answer: @entity5


abstract: INTRODUCTION: The @entity7 ( @entity7 )-02 study established @entity6 and @entity2 (CisGem) as a reference 1(st)-line regimen for @entity0 with advanced/metastatic @entity7 ; @entity0 with @entity5    1.5  * upper limit of normal (ULN) were excluded and there are few extant data for systemic treatment in the context of elevated @entity5 . METHODS: @entity0 with @entity7 , receiving CisGem with a baseline @entity5 of    1.5*ULN were eligible for this retrospective analysis; response, @entity3 and survival data were collected. RESULTS: Thirty-three @entity0 of 545 screened; median age 59years, range 23-79; 58% male, 58% with @entity1 (79% in the liver) of performance status (PS) 0 (33%), 1 (64%) or 2 (3%) were eligible. The median baseline @entity5 was 55 mol/L (range 32-286); due to @entity4 ( @entity4 , 76%) or liver @entity1 (LM, 24%). @entity3 was comparable to the @entity7 -02 study; @entity5 normalised in 64% during chemotherapy/follow-up. The median progression-free survival (PFS) was 6.9months (95% confidence interval (CI): 4.4-9.0) and median @entity8 ( @entity8 ) 9.5months (95% CI: 5.7-12.8). @entity0 with @entity4 had a longer PFS and @entity8 than those with LM (7.0 versus 2.6months; p=0.1633 and 9.8 versus 4.4months, hazard ratio (HR) 0.74; p=0.465, respectively); not statistically significant (due to small sample size). Normalisation of @entity5 and completion of eight CisGem cycles were associated with longer @entity8 (11.4 versus 2.9months, HR 0.49; p=0.08 and 15.2 versus 5.4months, HR 0.12 p<0.001, respectively). No difference in @entity8 was shown between the @entity5 percentiles (for either PFS or @entity8 ). CONCLUSION: For PS 0-1 @entity0 with @entity7 and high @entity5 due to luminal disease despite optimal stenting CisGem can be used safely with results similar to those in @entity0 with normal @entity5 .

title: XXXX and @entity2 in @entity0 with @entity7 ( @entity7 ) and persistent jaundice despite optimal stenting: Effective intervention in @entity0 with luminal disease.

answer: @entity6


abstract: INTRODUCTION: The @entity7 ( @entity7 )-02 study established @entity6 and @entity2 (CisGem) as a reference 1(st)-line regimen for @entity0 with advanced/metastatic @entity7 ; @entity0 with @entity5    1.5  * upper limit of normal (ULN) were excluded and there are few extant data for systemic treatment in the context of elevated @entity5 . METHODS: @entity0 with @entity7 , receiving CisGem with a baseline @entity5 of    1.5*ULN were eligible for this retrospective analysis; response, @entity3 and survival data were collected. RESULTS: Thirty-three @entity0 of 545 screened; median age 59years, range 23-79; 58% male, 58% with @entity1 (79% in the liver) of performance status (PS) 0 (33%), 1 (64%) or 2 (3%) were eligible. The median baseline @entity5 was 55 mol/L (range 32-286); due to @entity4 ( @entity4 , 76%) or liver @entity1 (LM, 24%). @entity3 was comparable to the @entity7 -02 study; @entity5 normalised in 64% during chemotherapy/follow-up. The median progression-free survival (PFS) was 6.9months (95% confidence interval (CI): 4.4-9.0) and median @entity8 ( @entity8 ) 9.5months (95% CI: 5.7-12.8). @entity0 with @entity4 had a longer PFS and @entity8 than those with LM (7.0 versus 2.6months; p=0.1633 and 9.8 versus 4.4months, hazard ratio (HR) 0.74; p=0.465, respectively); not statistically significant (due to small sample size). Normalisation of @entity5 and completion of eight CisGem cycles were associated with longer @entity8 (11.4 versus 2.9months, HR 0.49; p=0.08 and 15.2 versus 5.4months, HR 0.12 p<0.001, respectively). No difference in @entity8 was shown between the @entity5 percentiles (for either PFS or @entity8 ). CONCLUSION: For PS 0-1 @entity0 with @entity7 and high @entity5 due to luminal disease despite optimal stenting CisGem can be used safely with results similar to those in @entity0 with normal @entity5 .

title: @entity6 and @entity2 in @entity0 with XXXX ( @entity7 ) and persistent jaundice despite optimal stenting: Effective intervention in @entity0 with luminal disease.

answer: @entity7


abstract: INTRODUCTION: The @entity7 ( @entity7 )-02 study established @entity6 and @entity2 (CisGem) as a reference 1(st)-line regimen for @entity0 with advanced/metastatic @entity7 ; @entity0 with @entity5    1.5  * upper limit of normal (ULN) were excluded and there are few extant data for systemic treatment in the context of elevated @entity5 . METHODS: @entity0 with @entity7 , receiving CisGem with a baseline @entity5 of    1.5*ULN were eligible for this retrospective analysis; response, @entity3 and survival data were collected. RESULTS: Thirty-three @entity0 of 545 screened; median age 59years, range 23-79; 58% male, 58% with @entity1 (79% in the liver) of performance status (PS) 0 (33%), 1 (64%) or 2 (3%) were eligible. The median baseline @entity5 was 55 mol/L (range 32-286); due to @entity4 ( @entity4 , 76%) or liver @entity1 (LM, 24%). @entity3 was comparable to the @entity7 -02 study; @entity5 normalised in 64% during chemotherapy/follow-up. The median progression-free survival (PFS) was 6.9months (95% confidence interval (CI): 4.4-9.0) and median @entity8 ( @entity8 ) 9.5months (95% CI: 5.7-12.8). @entity0 with @entity4 had a longer PFS and @entity8 than those with LM (7.0 versus 2.6months; p=0.1633 and 9.8 versus 4.4months, hazard ratio (HR) 0.74; p=0.465, respectively); not statistically significant (due to small sample size). Normalisation of @entity5 and completion of eight CisGem cycles were associated with longer @entity8 (11.4 versus 2.9months, HR 0.49; p=0.08 and 15.2 versus 5.4months, HR 0.12 p<0.001, respectively). No difference in @entity8 was shown between the @entity5 percentiles (for either PFS or @entity8 ). CONCLUSION: For PS 0-1 @entity0 with @entity7 and high @entity5 due to luminal disease despite optimal stenting CisGem can be used safely with results similar to those in @entity0 with normal @entity5 .

title: @entity6 and @entity2 in @entity0 with @entity7 ( XXXX ) and persistent jaundice despite optimal stenting: Effective intervention in @entity0 with luminal disease.

answer: @entity7


abstract: INTRODUCTION: The @entity7 ( @entity7 )-02 study established @entity6 and @entity2 (CisGem) as a reference 1(st)-line regimen for @entity0 with advanced/metastatic @entity7 ; @entity0 with @entity5    1.5  * upper limit of normal (ULN) were excluded and there are few extant data for systemic treatment in the context of elevated @entity5 . METHODS: @entity0 with @entity7 , receiving CisGem with a baseline @entity5 of    1.5*ULN were eligible for this retrospective analysis; response, @entity3 and survival data were collected. RESULTS: Thirty-three @entity0 of 545 screened; median age 59years, range 23-79; 58% male, 58% with @entity1 (79% in the liver) of performance status (PS) 0 (33%), 1 (64%) or 2 (3%) were eligible. The median baseline @entity5 was 55 mol/L (range 32-286); due to @entity4 ( @entity4 , 76%) or liver @entity1 (LM, 24%). @entity3 was comparable to the @entity7 -02 study; @entity5 normalised in 64% during chemotherapy/follow-up. The median progression-free survival (PFS) was 6.9months (95% confidence interval (CI): 4.4-9.0) and median @entity8 ( @entity8 ) 9.5months (95% CI: 5.7-12.8). @entity0 with @entity4 had a longer PFS and @entity8 than those with LM (7.0 versus 2.6months; p=0.1633 and 9.8 versus 4.4months, hazard ratio (HR) 0.74; p=0.465, respectively); not statistically significant (due to small sample size). Normalisation of @entity5 and completion of eight CisGem cycles were associated with longer @entity8 (11.4 versus 2.9months, HR 0.49; p=0.08 and 15.2 versus 5.4months, HR 0.12 p<0.001, respectively). No difference in @entity8 was shown between the @entity5 percentiles (for either PFS or @entity8 ). CONCLUSION: For PS 0-1 @entity0 with @entity7 and high @entity5 due to luminal disease despite optimal stenting CisGem can be used safely with results similar to those in @entity0 with normal @entity5 .

title: @entity6 and @entity2 in XXXX with @entity7 ( @entity7 ) and persistent jaundice despite optimal stenting: Effective intervention in @entity0 with luminal disease.

answer: @entity0


abstract: INTRODUCTION: The @entity7 ( @entity7 )-02 study established @entity6 and @entity2 (CisGem) as a reference 1(st)-line regimen for @entity0 with advanced/metastatic @entity7 ; @entity0 with @entity5    1.5  * upper limit of normal (ULN) were excluded and there are few extant data for systemic treatment in the context of elevated @entity5 . METHODS: @entity0 with @entity7 , receiving CisGem with a baseline @entity5 of    1.5*ULN were eligible for this retrospective analysis; response, @entity3 and survival data were collected. RESULTS: Thirty-three @entity0 of 545 screened; median age 59years, range 23-79; 58% male, 58% with @entity1 (79% in the liver) of performance status (PS) 0 (33%), 1 (64%) or 2 (3%) were eligible. The median baseline @entity5 was 55 mol/L (range 32-286); due to @entity4 ( @entity4 , 76%) or liver @entity1 (LM, 24%). @entity3 was comparable to the @entity7 -02 study; @entity5 normalised in 64% during chemotherapy/follow-up. The median progression-free survival (PFS) was 6.9months (95% confidence interval (CI): 4.4-9.0) and median @entity8 ( @entity8 ) 9.5months (95% CI: 5.7-12.8). @entity0 with @entity4 had a longer PFS and @entity8 than those with LM (7.0 versus 2.6months; p=0.1633 and 9.8 versus 4.4months, hazard ratio (HR) 0.74; p=0.465, respectively); not statistically significant (due to small sample size). Normalisation of @entity5 and completion of eight CisGem cycles were associated with longer @entity8 (11.4 versus 2.9months, HR 0.49; p=0.08 and 15.2 versus 5.4months, HR 0.12 p<0.001, respectively). No difference in @entity8 was shown between the @entity5 percentiles (for either PFS or @entity8 ). CONCLUSION: For PS 0-1 @entity0 with @entity7 and high @entity5 due to luminal disease despite optimal stenting CisGem can be used safely with results similar to those in @entity0 with normal @entity5 .

title: @entity6 and @entity2 in @entity0 with @entity7 ( @entity7 ) and persistent jaundice despite optimal stenting: Effective intervention in XXXX with luminal disease.

answer: @entity0


abstract: INTRODUCTION: The @entity7 ( @entity7 )-02 study established @entity6 and @entity2 (CisGem) as a reference 1(st)-line regimen for @entity0 with advanced/metastatic @entity7 ; @entity0 with @entity5    1.5  * upper limit of normal (ULN) were excluded and there are few extant data for systemic treatment in the context of elevated @entity5 . METHODS: @entity0 with @entity7 , receiving CisGem with a baseline @entity5 of    1.5*ULN were eligible for this retrospective analysis; response, @entity3 and survival data were collected. RESULTS: Thirty-three @entity0 of 545 screened; median age 59years, range 23-79; 58% male, 58% with @entity1 (79% in the liver) of performance status (PS) 0 (33%), 1 (64%) or 2 (3%) were eligible. The median baseline @entity5 was 55 mol/L (range 32-286); due to @entity4 ( @entity4 , 76%) or liver @entity1 (LM, 24%). @entity3 was comparable to the @entity7 -02 study; @entity5 normalised in 64% during chemotherapy/follow-up. The median progression-free survival (PFS) was 6.9months (95% confidence interval (CI): 4.4-9.0) and median @entity8 ( @entity8 ) 9.5months (95% CI: 5.7-12.8). @entity0 with @entity4 had a longer PFS and @entity8 than those with LM (7.0 versus 2.6months; p=0.1633 and 9.8 versus 4.4months, hazard ratio (HR) 0.74; p=0.465, respectively); not statistically significant (due to small sample size). Normalisation of @entity5 and completion of eight CisGem cycles were associated with longer @entity8 (11.4 versus 2.9months, HR 0.49; p=0.08 and 15.2 versus 5.4months, HR 0.12 p<0.001, respectively). No difference in @entity8 was shown between the @entity5 percentiles (for either PFS or @entity8 ). CONCLUSION: For PS 0-1 @entity0 with @entity7 and high @entity5 due to luminal disease despite optimal stenting CisGem can be used safely with results similar to those in @entity0 with normal @entity5 .

title: @entity6 and XXXX in @entity0 with @entity7 ( @entity7 ) and persistent jaundice despite optimal stenting: Effective intervention in @entity0 with luminal disease.

answer: @entity2


abstract: @entity0 glomerular epithelial and mesangial cells, and @entity0 skin fibroblasts, were cultured in RPMI medium containing 15% decomplemented fetal bovine serum. They were incubated for 1 h at 37 degrees C with 2 mM [ @entity1 ]. At that time, their response to various concentrations of @entity3 , @entity2 and @entity5 was studied by phase contrast microscopy. Only the mesangial cells exhibited contractile activity in the presence of 10(-10) M @entity3 and 10(-6) M @entity2 , as demonstrated by the reduction of their length or, more frequently, by modification of their shape. No contractile activity was observed in the presence of 10(-5) M @entity5 . The percentage of contractile cells increased proportionally to the concentration of @entity3 , reaching about 35% with 10(-6) M @entity3 . The contractile activity was reversible. Specific inhibitors, i.e. Sar1-ala8- @entity3 and @entity4 , when administered in concentrations 10 to 100-fold higher than that of the corresponding agonists, completely blocked the contractile response. This competitive effect was also reversible. The data, therefore, suggest that mesangial cells in culture display some functional properties of smooth muscle cells.

title: Tissue culture of normal XXXX glomeruli: contractile activity of the cultured mesangial cells.

answer: @entity0


abstract: Ninety-four consecutive @entity0 with unilateral enucleations or eviscerations were tested by the Schirmer I and Schirmer II tests for tear production. The findings on the artificial eye were compared with those on the companion, living (control) eye. The collected data were subjected to statistical analysis. The control eyes were shown to respond in the normal manner, more tears without topical anesthetic than with it. The sockets of artificial eyes produced no more tears without anesthetic than with it. The control eyes produced a normal amount of reflex tears, whereas the sockets of many artificial eyes produced practically no reflex tears. Tear production in @entity0 with no complaints was compared to those with noteworthy problems. @entity0 with problems had only half as much basic tear secretion as those without problems. Elimination of the stimulus to reflex tear production by removal of the @entity1 and by the presence of the prosthesis is suggested as the cause of @entity2 . The potential value of aqueous or oily artificial lubricants is mentioned.

title: XXXX and tear measurements.

answer: @entity2


abstract: This report examines two cases of @entity8 by @entity9 (L.m.). Both cases show that listeriosis is not only a differential diagnosis of @entity3 , but can also be the cause of an isolated @entity7 with normal cerebrospinal fluid cell count. The prognosis depends crucially on the early antibiotic therapy ( @entity4 ). The first @entity0 was a chronic alcoholic. He died of fulminant @entity2 and @entity3 with @entity7 (cell count of cerebrospinal fluid: 10500/microliters). L.m. was isolated from blood cultures and from cerebrospinal fluid. The second @entity0 had no indications of preexisting @entity5 . Two days after perianal injections for haemorrhoids, symptoms of a progredient @entity7 developed. The cell count of cerebrospinal fluid was only 10/mu, but L.m. was isolated from blood cultures. The @entity0 died of @entity6 . At autopsy, a @entity7 and cerebellitis with @entity1 of the surrounding leptomeninx was identified.

title: [Infection of the CNS caused by XXXX ].

answer: @entity9


abstract: Background.: @entity5 occur in 38 % of @entity0 with @entity3 ( @entity3 ) and may cause @entity2 and increased abdominal girth, mimicking the presence of a @entity1 . Lymphatic involvement in @entity3 is closely associated with elevated serum levels of @entity4 ( @entity4 ). Since @entity5 undergo diurnal variation in volume, we hypothesized that the ingestion of food during day time, by increasing chyle formation and lymphatic flow, is the cause of an increase in @entity5 volume. Methods.: @entity0 had abdomino-pelvic sonograms and blood drawn for measurement of serum @entity4 under non-fasting (day 1) and fasting (day 2) conditions. The size of the @entity5 was determined by a radiologist who was blinded to the subjects' status. The Wilcoxon signed rank test was used to determine whether the non-fasting @entity1 size was different from the fasting @entity1 size. Results.: Thirty-five @entity0 were studied (age=45.2  8.5 years, FEV1= 82  25 % and DLCO 64  25 % predicted); images suitable for volume measurements were obtained in 30. Fasting decreased the @entity1 size by 20.7  39.3 cm3 (24  40 %), (p<0.001). Fasting @entity4 levels (10,650  900 pg/ml) were not significantly different from non-fasting values (12,100  800 pg/ml) (p=0.56). Conclusions.: @entity5 volume decreased during the fasting state. Conversely, a combination of food intake and decreased chyle flow through lymphatics partially obstructed by @entity3 cells, may account for increases in @entity5 size. Imaging studies performed under fasting conditions may help in determining whether an @entity1 is a result of @entity3 or a @entity1 .

title: Effect of Fasting on the Size of @entity5 in @entity0 with XXXX .

answer: @entity3


abstract: Background.: @entity5 occur in 38 % of @entity0 with @entity3 ( @entity3 ) and may cause @entity2 and increased abdominal girth, mimicking the presence of a @entity1 . Lymphatic involvement in @entity3 is closely associated with elevated serum levels of @entity4 ( @entity4 ). Since @entity5 undergo diurnal variation in volume, we hypothesized that the ingestion of food during day time, by increasing chyle formation and lymphatic flow, is the cause of an increase in @entity5 volume. Methods.: @entity0 had abdomino-pelvic sonograms and blood drawn for measurement of serum @entity4 under non-fasting (day 1) and fasting (day 2) conditions. The size of the @entity5 was determined by a radiologist who was blinded to the subjects' status. The Wilcoxon signed rank test was used to determine whether the non-fasting @entity1 size was different from the fasting @entity1 size. Results.: Thirty-five @entity0 were studied (age=45.2  8.5 years, FEV1= 82  25 % and DLCO 64  25 % predicted); images suitable for volume measurements were obtained in 30. Fasting decreased the @entity1 size by 20.7  39.3 cm3 (24  40 %), (p<0.001). Fasting @entity4 levels (10,650  900 pg/ml) were not significantly different from non-fasting values (12,100  800 pg/ml) (p=0.56). Conclusions.: @entity5 volume decreased during the fasting state. Conversely, a combination of food intake and decreased chyle flow through lymphatics partially obstructed by @entity3 cells, may account for increases in @entity5 size. Imaging studies performed under fasting conditions may help in determining whether an @entity1 is a result of @entity3 or a @entity1 .

title: Effect of Fasting on the Size of XXXX in @entity0 with @entity3 .

answer: @entity5


abstract: Background.: @entity5 occur in 38 % of @entity0 with @entity3 ( @entity3 ) and may cause @entity2 and increased abdominal girth, mimicking the presence of a @entity1 . Lymphatic involvement in @entity3 is closely associated with elevated serum levels of @entity4 ( @entity4 ). Since @entity5 undergo diurnal variation in volume, we hypothesized that the ingestion of food during day time, by increasing chyle formation and lymphatic flow, is the cause of an increase in @entity5 volume. Methods.: @entity0 had abdomino-pelvic sonograms and blood drawn for measurement of serum @entity4 under non-fasting (day 1) and fasting (day 2) conditions. The size of the @entity5 was determined by a radiologist who was blinded to the subjects' status. The Wilcoxon signed rank test was used to determine whether the non-fasting @entity1 size was different from the fasting @entity1 size. Results.: Thirty-five @entity0 were studied (age=45.2  8.5 years, FEV1= 82  25 % and DLCO 64  25 % predicted); images suitable for volume measurements were obtained in 30. Fasting decreased the @entity1 size by 20.7  39.3 cm3 (24  40 %), (p<0.001). Fasting @entity4 levels (10,650  900 pg/ml) were not significantly different from non-fasting values (12,100  800 pg/ml) (p=0.56). Conclusions.: @entity5 volume decreased during the fasting state. Conversely, a combination of food intake and decreased chyle flow through lymphatics partially obstructed by @entity3 cells, may account for increases in @entity5 size. Imaging studies performed under fasting conditions may help in determining whether an @entity1 is a result of @entity3 or a @entity1 .

title: Effect of Fasting on the Size of @entity5 in XXXX with @entity3 .

answer: @entity0


abstract: INTRODUCTION: @entity5 is the most common complication after @entity4 for cesarean delivery. Several therapeutic and preventive measures are used to attenuate this side effect. @entity6 receptor-blocking drugs have been suggested as one such approach. We sought to determine whether prophylactically administered intravenous @entity8 could attenuate @entity5 in @entity0 undergoing elective cesarean delivery performed under @entity4 . METHODS: Eighty-six @entity0 undergoing elective cesarean delivery were recruited and randomly allocated to receive either 8 mg intravenous @entity8 (group O; n = 44) or placebo (group P; n = 42) in a prospective double-blind design. Systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP), and heart rate (HR) were measured at baseline and at 3-minute intervals from the time of initiation of @entity4 until delivery. @entity8 effect on hemodynamics (SBP, @entity5 ) was quantified and analyzed using a linear mixed effect model. RESULTS: We did not find differences in SBP (P = 0.78), MAP (P = 0.89), DBP (P = 0.82), or HR (P = 0.18) between the 2 groups during the study period. @entity7 requirements to treat @entity5 were 350  g (175-700  g) in group O and 450  g (300-700  g) in group P (P = 0.30). The incidence of @entity1 was 63% (n = 28 of 44) in group O and 56% (n = 23 of 42) in group P (difference, 0.08 [95% confidence interval, -0.23 to 0.41], P = 0.59). No difference in the incidence of @entity2 and @entity3 or sensory level was found. CONCLUSIONS: @entity8 premedication does not attenuate hemodynamic changes after @entity4 nor does it reduce the amount of vasopressor use, @entity1 , or @entity2 and @entity3 .

title: XXXX Does Not Attenuate Hemodynamic Changes in @entity0 Undergoing Elective Cesarean Delivery Using Subarachnoid Anesthesia: A Double-Blind, Placebo-Controlled, Randomized Trial.

answer: @entity8


abstract: INTRODUCTION: @entity5 is the most common complication after @entity4 for cesarean delivery. Several therapeutic and preventive measures are used to attenuate this side effect. @entity6 receptor-blocking drugs have been suggested as one such approach. We sought to determine whether prophylactically administered intravenous @entity8 could attenuate @entity5 in @entity0 undergoing elective cesarean delivery performed under @entity4 . METHODS: Eighty-six @entity0 undergoing elective cesarean delivery were recruited and randomly allocated to receive either 8 mg intravenous @entity8 (group O; n = 44) or placebo (group P; n = 42) in a prospective double-blind design. Systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP), and heart rate (HR) were measured at baseline and at 3-minute intervals from the time of initiation of @entity4 until delivery. @entity8 effect on hemodynamics (SBP, @entity5 ) was quantified and analyzed using a linear mixed effect model. RESULTS: We did not find differences in SBP (P = 0.78), MAP (P = 0.89), DBP (P = 0.82), or HR (P = 0.18) between the 2 groups during the study period. @entity7 requirements to treat @entity5 were 350  g (175-700  g) in group O and 450  g (300-700  g) in group P (P = 0.30). The incidence of @entity1 was 63% (n = 28 of 44) in group O and 56% (n = 23 of 42) in group P (difference, 0.08 [95% confidence interval, -0.23 to 0.41], P = 0.59). No difference in the incidence of @entity2 and @entity3 or sensory level was found. CONCLUSIONS: @entity8 premedication does not attenuate hemodynamic changes after @entity4 nor does it reduce the amount of vasopressor use, @entity1 , or @entity2 and @entity3 .

title: @entity8 Does Not Attenuate Hemodynamic Changes in XXXX Undergoing Elective Cesarean Delivery Using Subarachnoid Anesthesia: A Double-Blind, Placebo-Controlled, Randomized Trial.

answer: @entity0


abstract: In female NIH strain @entity0 , expulsion of a primary @entity1 of the @entity3 @entity4 began on day 8 and was virtually complete by day 14 of @entity1 . In secondary and tertiary @entity1 , the number of larvae which established in the intestine was normal, but expulsion began on day 6 and was complete on day 10. In a primary @entity1 the shedding of larvae by female worms began on day 5, reached its peak on days 6--7, began to decrease on day 8 and was minimal by day 10. In secondary and tertiary @entity1 fecundity was @entity2 . The @entity2 of fecundity occurred slightly in advance of worm loss. During the stable phase of @entity1 , @entity4 occurred in the anterior half of the small intestine. During expulsion, living worms were found increasingly in more posterior parts of the gut but their fecundity did not vary with position. After direct inoculation into the posterior ileum, adult and larval @entity4 remained in the posterior half of the small intestine. In this position, larvae established in normal numbers, grew and reproduced normally. Therefore, any part of the small intestine was a suitable site for @entity4 and expulsion is not merely due to a change in the position of the worms.

title: Effects of the host immune response on the longevity, fecundity and position in the intestine of XXXX in @entity0 .

answer: @entity4


abstract: In female NIH strain @entity0 , expulsion of a primary @entity1 of the @entity3 @entity4 began on day 8 and was virtually complete by day 14 of @entity1 . In secondary and tertiary @entity1 , the number of larvae which established in the intestine was normal, but expulsion began on day 6 and was complete on day 10. In a primary @entity1 the shedding of larvae by female worms began on day 5, reached its peak on days 6--7, began to decrease on day 8 and was minimal by day 10. In secondary and tertiary @entity1 fecundity was @entity2 . The @entity2 of fecundity occurred slightly in advance of worm loss. During the stable phase of @entity1 , @entity4 occurred in the anterior half of the small intestine. During expulsion, living worms were found increasingly in more posterior parts of the gut but their fecundity did not vary with position. After direct inoculation into the posterior ileum, adult and larval @entity4 remained in the posterior half of the small intestine. In this position, larvae established in normal numbers, grew and reproduced normally. Therefore, any part of the small intestine was a suitable site for @entity4 and expulsion is not merely due to a change in the position of the worms.

title: Effects of the host immune response on the longevity, fecundity and position in the intestine of @entity4 in XXXX .

answer: @entity0


abstract: BACKGROUND: A partial smoke-free regulation in Spain was introduced on January 1, 2006, which was subsequently amended to introduce a comprehensive smoke-free policy from 2 January 2011 onward. The objective of this study was to compare the prevalence of @entity0 consumption in Spain and the profile of smokers before (2006) and after (2011) the comprehensive smoking ban passed in 2010. METHODS: Two independent, cross-sectional, population-based surveys were carried out among the adult (>=  18 years old) Spanish population in 2006 and 2011 through telephone interviews. Both surveys used the same methods and questionnaire. @entity2 @entity1 was assessed with the Fagerstr  m Test for @entity2 @entity1 and readiness to quit according to the stages of change. RESULTS: The prevalence of @entity0 consumption showed a nonsignificant decrease from 23.4% in 2006 to 20.7% in 2011. No changes were observed in @entity2 @entity1 or readiness to quit. In 2011, most smokers (76%) showed low @entity2 @entity1 and were mainly in the precontemplation stage (72%). CONCLUSIONS: The prevalence of smokers has slightly decreased since the introduction of the total smoking ban in Spain. No differences were found in @entity2 @entity1 or readiness to quit.

title: Changes in the Prevalence of XXXX Consumption and the Profile of Spanish Smokers after a Comprehensive Smoke-Free Policy.

answer: @entity0


abstract: PURPOSE: To assess the effects of phacoemulsification, intraocular lens implantation, and goniosynechialysis on @entity0 with primary @entity3 and @entity1 . METHODS: A total of 145 eyes of 133 consecutively recruited @entity0 were randomly divided into Phaco group and Trab group. Ocular parameters were measured before and after surgery. RESULTS: The mean follow-up period was 13.2  5.6 months. The visual acuity in the Phaco group was significantly improved, whereas no alternation was found in the Trab group after surgery. The intraocular pressure (IOP) had no notable difference in 2 groups before surgery. Compared with preoperative IOP, there was significant decrease after surgery. No remarkable change in the IOP was measured in the 2 groups after surgery for 12 months. The anterior chamber depth was markedly augmented in the Phaco group compared with the Trab group after surgery for 3 months. Compared with the the Trab group, no obvious change in coefficient of outflow facility was found in the Phaco group before and after surgery, whereas there was a significant increase relative to its preoperation. The angle closure decreased from (290  25) to (60  35) degrees after surgery for 12 months in the Phaco group and no significant alteration was observed in the Trab group. The reduction extent of @entity2 was in direct proportion to the decreasing level of angle closure in the 2 groups. The change in the corneal endothelial cell density had no significant difference between 2 groups before and after surgery. CONCLUSIONS: The treatment of phacoemulsification, intraocular lens implantation, and goniosynechialysis is safe and effective for @entity0 with primary @entity3 and @entity1 .

title: Effects of Phacoemulsification Combined With Goniosynechialysis on Primary XXXX .

answer: @entity3


abstract: PURPOSE: To determine if @entity1 surgery on eyes with @entity2 confers as much functional visual improvement as surgery on eyes without retinal pathology. METHODS: This is a retrospective analysis of 4924 @entity1 surgeries from the Veterans Healthcare Administration Ophthalmic Surgical Outcomes Data Project (OSOD). We included cases of eyes with @entity2 that had both preoperative and postoperative NEI-VFQ-25 questionnaires submitted and compared their outcomes with controls without retinal pathology. We excluded @entity0 with other retinal pathologies (740 @entity0 ). The analyses compared changes in visual acuity and overall functional visual improvement and its subscales using t-tests, multivariate logistic regressions, and linear regression modeling. RESULTS: Preoperative and postoperative questionnaires were submitted by 58.3% of @entity2 and 63.8% of no retinal pathology cases (controls). Analysis of overall score showed that @entity1 surgery on eyes with @entity2 led to increased visual function (13.8    2.4 NEI-VFQ units, P < 0.0001); however, increases were significantly less when compared with controls (-6.4    2.9 NEI-VFQ units, P < 0.0001). Preoperative best-corrected visual acuity (preBCVA) in @entity2 was predictive of postoperative visual function (r = -0.38, P < 0.0001). In controls, postoperative visual function was only weakly associated with preBCVA (r = -0.075, P = 0.0002). @entity0 with @entity2 with vision of 20/40 or better had overall outcomes similar to controls (-2.2    4.7 NEI-VFQ units, P = 0.37). CONCLUSIONS: @entity1 surgery on eyes with @entity2 offers an increase in functional visual improvement; however, the amount of benefit is associated with the eye's preBCVA. For eyes with preBCVA of 20/40 or greater, the improvement is similar to that of @entity0 without retinal pathology. However, if preBCVA is less than 20/40, the amount of improvement was shown to be significantly less and decreased with decreasing preBCVA.

title: Functional Visual Improvement After XXXX Surgery in Eyes With Age-Related Macular Degeneration: Results of the Ophthalmic Surgical Outcomes Data Project.

answer: @entity1


abstract: An opportunity to study the effects of @entity9 @entity8 in @entity0 was provided by the large outbreak in Iraq in 1971-2. In adults, @entity8 resulted from the ingestion of home-made bread prepared from @entity9 -treated seed grain and there was a highly significant correlation between the amount of bread ingested and blood @entity3 levels. Poisoning in @entity0 resulted either from prior exposure in utero or from suckling or both. Blood @entity3 levels were higher in @entity0 and @entity0 than in adults. There was no increased incidence of @entity1 . Symptoms and signs of @entity8 and histopathological changes were mainly confined to the CNS. Symptoms developed, on average, 1-2 months after exposure. In @entity0 there was @entity5 with delayed onset of speech and impaired motor, sensory and autonomic function. Severely affected @entity0 were blind and deaf. In adults, the clinical picture could be classified as 1, mild (mainly of sensory symptoms) 2, moderate (sensory symptoms accompanied by cerebellar signs) and 3, severe (gross ataxia with marked @entity2 which, in some cases, progressed to @entity7 mutism followed by @entity4 ). Grades 1 and 2 carried a better prognosis thant grade 3. Interference with transmission at the myoneural junction was found in 14% of @entity0 studied. There was no evidence of peripheral nerve involvement per se and sensory symptoms may be of central origin. The clinical differences between the Iraqi and Japanese outbreaks may be a result, in part at least, of the severe, prolonged and continuous exposure which occurred in the latter outbreak. Improvement was observed among the mild and moderate group. Treatment with chelating agents, @entity6 resin, haemodialysis and exchange transfusion lowered blood @entity3 concentrations but produced no convincing clinical benefit. To be effective, treatment may need to be instituted soon after exposure.

title: Clinical and epidemiological aspects of @entity9 XXXX .

answer: @entity8


abstract: An opportunity to study the effects of @entity9 @entity8 in @entity0 was provided by the large outbreak in Iraq in 1971-2. In adults, @entity8 resulted from the ingestion of home-made bread prepared from @entity9 -treated seed grain and there was a highly significant correlation between the amount of bread ingested and blood @entity3 levels. Poisoning in @entity0 resulted either from prior exposure in utero or from suckling or both. Blood @entity3 levels were higher in @entity0 and @entity0 than in adults. There was no increased incidence of @entity1 . Symptoms and signs of @entity8 and histopathological changes were mainly confined to the CNS. Symptoms developed, on average, 1-2 months after exposure. In @entity0 there was @entity5 with delayed onset of speech and impaired motor, sensory and autonomic function. Severely affected @entity0 were blind and deaf. In adults, the clinical picture could be classified as 1, mild (mainly of sensory symptoms) 2, moderate (sensory symptoms accompanied by cerebellar signs) and 3, severe (gross ataxia with marked @entity2 which, in some cases, progressed to @entity7 mutism followed by @entity4 ). Grades 1 and 2 carried a better prognosis thant grade 3. Interference with transmission at the myoneural junction was found in 14% of @entity0 studied. There was no evidence of peripheral nerve involvement per se and sensory symptoms may be of central origin. The clinical differences between the Iraqi and Japanese outbreaks may be a result, in part at least, of the severe, prolonged and continuous exposure which occurred in the latter outbreak. Improvement was observed among the mild and moderate group. Treatment with chelating agents, @entity6 resin, haemodialysis and exchange transfusion lowered blood @entity3 concentrations but produced no convincing clinical benefit. To be effective, treatment may need to be instituted soon after exposure.

title: Clinical and epidemiological aspects of XXXX @entity8 .

answer: @entity9


abstract: OBJECTIVES: Within the past several years, innovative communication tools have been established as viable quality improvement mechanisms in health care. Meanwhile, the economic and societal burdens of @entity2 ( @entity2 ) continue to rise. Various interventions have been attempted to reduce @entity2 . This study evaluated the effectiveness of a communication tool in reducing risk factors for @entity2 . METHODS: A communication tool aimed at reducing HAC risk factors was developed by an interdisciplinary team of physicians and nurses and tested in a simple before-after quality improvement study. It included 8 components: ambulation/fall risk, blood @entity1 greater than 200 mg/dL, central venous catheters, @entity3 prophylaxis, erosions of the skin/dermal ulcers, Foley/urinary catheters, got communication, and heart monitor/telemetry. This communication tool facilitated multidisciplinary communication. The nurses completed it nightly, and the physicians reviewed the communication tool each morning and, when appropriate, addressed components of care that were out of compliance with best practices. RESULTS: The use of the ABCs of Hospitalized @entity0 Communication Tool led to daily improvements with reduction in the percentage of @entity0 with blood @entity1 greater than 200 mg/dL from 43.3% to 35.1%, reduction in the use of central venous catheters from 8.2% to 1.0% of @entity0 , increase in the use of chemical @entity3 prophylaxis from 45.4% of @entity0 to 56.7%, reduction in the use of urinary catheters from 27.6% to 13.2%, and decrease in use of telemetry from 67.5% to 55.1%. All of the results have P < 0.05. These improvements were sustained over time. CONCLUSIONS: Implementation of a multidisciplinary communication tool serves as a simple, resource-conscious, and customizable instrument to reduce the risk factors for developing @entity2 . This communication tool can be easily disseminated and used by other institutions.

title: ABCs of Hospitalized XXXX : A Simple Before-After Study of a Communication Tool to Improve Quality of Inpatient Care.

answer: @entity0


abstract: BACKGROUND AND AIMS: Current guidelines favor the use of chelating agents ( @entity4 , @entity5 ) in first line therapy of symptomatic @entity3 @entity0 . Development of chelator induced immunological adverse events are a concern especially under @entity4 therapy. This study assessed the prevalence of co-existing or therapy-related immune-mediated diseases in @entity3 @entity0 , and evaluated the role of antinuclear antibodies in therapy monitoring. METHODS: We retrospectively analyzed 235 @entity3 @entity0 . Medical regimens were classified and analyzed in relation to adverse events and antinuclear antibody courses. RESULTS: Coexisting immune-mediated diseases were evident in 19/235 (8.1  %) @entity0 , of which 13/235 (5.5  %) had pre-existing @entity2 . Six @entity0 (2.6  %) developed an @entity2 under therapy, all of them under long-term @entity4 treatment. Data relating to antinuclear antibody courses during treatment and adverse events were available for @entity0 treated with @entity4 (n   =   91), @entity5 (n   =   58), and @entity1 salts (n   =   58). No significant increase in antinuclear antibody titers in @entity0 treated with @entity4 (16/91; 17.6  %), @entity5 (12/58; 20.7  %), and @entity1 (7/58; 12.1  %) were found. CONCLUSION: Under long-term @entity4 therapy a minority of @entity0 developed immune-mediated disease. Elevations in antinuclear antibodies were found frequently, but no correlations were evident between increases in antinuclear antibodies and the development of immune-mediated diseases or medical regimes. Thus, the value of antinuclear antibodies for monitoring adverse events under chelator therapy seems to be limited.

title: Concomitant immune-related events in XXXX : implications for monitoring chelator therapy.

answer: @entity3


abstract: BACKGROUND: Little evidence exists on the effects of receiving care in a @entity1 ( @entity1 ). OBJECTIVE: To examine @entity1 effects on mortality and Medicare payments overall and among high-acuity @entity0 . RESEARCH DESIGN: A retrospective cohort study of Medicare beneficiaries using probit and generalized linear models. An instrumental variable technique was used to adjust for selection bias. SUBJECTS: Medicare beneficiaries within 5 major diagnostic categories and not on prolonged mechanical ventilation. MEASURES: Mortality (365 d) and Medicare payments (180 d) during an episode of care. RESULTS: @entity1 care is associated with increases in Medicare payments ranging from  3146 to  17,589 (P<0.01) with no mortality benefit for 3 categories and payment reductions of  5419 and  5962 (P<0.01) at lower or similar mortality for 2 categories. @entity1 @entity0 with @entity2 experience lower mortality at similar or lower payments (3 categories) or similar mortality at lower payments (1 category) compared with @entity0 in other settings, with mortality benefits between 5.4 and 9.7 percentage points (P<0.05) and payment reductions between  13,806 and  20,809 (P<0.01). For 1 category, we found no difference in mortality or payments between @entity1 and non- @entity1 @entity0 with @entity2 . For @entity0 with >= 3 days in intensive care, @entity1 care is associated with improved mortality and lower payments in 4 and 3 categories, respectively. CONCLUSIONS: Receiving care in an @entity1 may improve outcomes for some @entity0 . Further research is needed to better define @entity0 for whom care in these hospitals is beneficial.

title: The Role of Long-term Acute Care Hospitals in Treating the Critically Ill and Medically Complex: An Analysis of Nonventilator XXXX .

answer: @entity0


abstract: @entity14 and @entity5 are, by far, the most common @entity4 affecting @entity0 , and both are influenced by diet. @entity14 occurs more commonly in @entity0 than @entity0 ; generally @entity0 are 10 to 15 years older than @entity0 when symptoms develop. The prevalence of @entity5 is about equal in the two sexes, particularly in middle aged and older @entity0 . These @entity4 are major causes of @entity9 and disability in this country. @entity14 results in @entity11 , @entity3 , and @entity12 . @entity5 , when severe, damages small blood vessels, causing @entity8 , @entity10 , @entity3 , and @entity13 ; when the condition is mild to moderate, it produces @entity14 . Nutritional factors are of primary importance in both @entity14 and @entity5 . Risk factors for @entity14 related to nutrition are @entity15 , @entity16 - @entity1 , and for @entity5 , @entity2 , high salt intake, and excessive use of @entity7 . Of all these risk factors, @entity2 seems to be the most important because it is strongly linked to @entity5 and @entity1 . Dietary intake of saturated fat is a potent factor in determining the blood @entity6 level, and reducing intake often decreases the level, thus lessening the risk of @entity14 . Although high salt intake and excessive @entity7 use produce @entity5 in susceptible @entity0 , less is known about the frequency of this adverse effect than is known about @entity2 .

title: Nutrition and XXXX of @entity0 .

answer: @entity4


abstract: @entity14 and @entity5 are, by far, the most common @entity4 affecting @entity0 , and both are influenced by diet. @entity14 occurs more commonly in @entity0 than @entity0 ; generally @entity0 are 10 to 15 years older than @entity0 when symptoms develop. The prevalence of @entity5 is about equal in the two sexes, particularly in middle aged and older @entity0 . These @entity4 are major causes of @entity9 and disability in this country. @entity14 results in @entity11 , @entity3 , and @entity12 . @entity5 , when severe, damages small blood vessels, causing @entity8 , @entity10 , @entity3 , and @entity13 ; when the condition is mild to moderate, it produces @entity14 . Nutritional factors are of primary importance in both @entity14 and @entity5 . Risk factors for @entity14 related to nutrition are @entity15 , @entity16 - @entity1 , and for @entity5 , @entity2 , high salt intake, and excessive use of @entity7 . Of all these risk factors, @entity2 seems to be the most important because it is strongly linked to @entity5 and @entity1 . Dietary intake of saturated fat is a potent factor in determining the blood @entity6 level, and reducing intake often decreases the level, thus lessening the risk of @entity14 . Although high salt intake and excessive @entity7 use produce @entity5 in susceptible @entity0 , less is known about the frequency of this adverse effect than is known about @entity2 .

title: Nutrition and @entity4 of XXXX .

answer: @entity0


abstract: OBJECTIVES: The aim of this study was to evaluate multisequence 3.0T magnetic resonance imaging (MRI) in the detection of severe @entity2 and in predicting the outcome. METHODS: Thirty-five @entity0 with severe @entity2 were prospectively enrolled and multisequence 3.0T MRI was performed 4-8 weeks post injury. Quantitative data were recorded on each sequence. The ability to display the parenchymal lesions was compared with that of 64-slice spiral computed tomography (CT). The clinical and radiological results were correlated with the Glasgow Outcome Scale Extended (GOSE) scores 6 months after injury. RESULTS: 3.0T MRI could display more lesions than CT, especially when the lesion was deeply located. The lesion volumes and @entity1 ( @entity1 ) scores were different between good and poor outcome groups on FLAIR (P < 0.05). The apparent diffusion coefficient (ADC) values of the splenium of the corpus callosum and brain stem were also different (P < 0.05). @entity0 with unfavorable outcome showed a significantly higher volume of @entity3 on susceptibility weighted imaging (SWI) than favorable ones and were generally located more deeply. Logistic regression analysis revealed that the location of @entity3 and the ADC values of the splenium of the corpus callosum were independent risk factors for poor outcome, with an overall predictive accuracy of 91.4%. CONCLUSION: The joint use of conventional and advanced sequences of 3.0T MRI can comprehensively detect the pathological changes occurring after severe @entity2 . @entity3 and non-hemorrhagic DAIs in deep structures strongly suggest poor outcome. Advances in knowledge: This article improves the understanding of advanced MRI sequences in detection of sTBI @entity0 and prediction of prognosis.

title: Use of Multisequence 3.0T MRI to Detect Severe XXXX and Predict the Outcome.

answer: @entity2


abstract: INTRODUCTION: @entity5 as a result of @entity2 are a serious problem with an enormous impact on the overall global disease burden due to the increasing prevalence of @entity2 . Because of long hospital stays, rehabilitation, often required home care and the use of social services @entity6 are costly. Therapy with growth factors could be an effective and innovative add-on to standard wound care. RESEARCH QUESTIONS: What is the benefit of therapies with growth factors alone or in combination with other technologies in the treatment of @entity2 foot ulcer assessed regarding medical, economical, social, ethical and juridical aspects? METHODS: We systematically searched relevant databases limited to English and German language and publications since 1990. Cost values were adjusted to the price level of 2008 and converted into @entity8 . A review and an assessment of the quality of publications were conducted following approved methodical standards conforming to evidence-based medicine and health economics. RESULTS: We identified 25 studies (14 @entity3 ( @entity3 ), nine cost-effectiveness analyses, two meta-analyses). The @entity3 compared an add-on therapy to standard wound care with standard wound care/placebo alone or extracellular wound matrix: in six studies becaplermin, in two rhEGF, in one @entity4 , and in five studies the metabolically active skin grafts Dermagraft and Apligraf. The study duration ranged from twelve to 20 weeks and the study population included between 17 to 382 @entity0 , average 130 @entity0 . The treatment with @entity9 , rhEGF and skin implants Dermagraft and Apligraf showed in eight out of 13 studies an advantage concerning complete wound closure and the time to complete wound healing. Evidence for a benefit of treatment with @entity4 could not be found. In four out of 14 studies the proportion of adverse events was 30% per study group with no difference between the treatment groups. The methodological quality of the studies was affected by significant deficiencies. The results showed becaplermin being cost-effective whereas no obvious statement can be made regarding Dermagraft and Apligraf because of diverging cost bases and incremental cost-effectiveness ratios. DISCUSSION: Differences in standard wound care are complicating the comparison of study results. Taking into consideration the small to very small sample sizes and other methodological flaws with high potential of bias, the validity of the results with regard to effectiveness and cost-effectiveness has to be considered limited. The duration of treatment and follow-up examinations is not long enough to assess the sustainability of the intervention and the surveillance of @entity5 or treatment related adverse events like the development of @entity1 . CONCLUSIONS: There are indications of an advantage for the add-on therapy with growth factors in @entity7 concerning complete wound closure and the time to complete wound healing. Further more studies of high methodological quality with adequate sample sizes and sufficient follow-up periods are necessary also investigating @entity0 -relevant parameters like the health-related quality of life, the acceptance and tolerance of the intervention in addition to clinical outcomes.

title: The importance of growth factors for the treatment of chronic wounds in the case of XXXX .

answer: @entity7


abstract: BACKGROUND: In 2003 nearly 20% of deaths in Germany were caused by @entity1 ( @entity1 ). Risk models are used to estimate the ten-year-risk of a coronary event. Coronary calcification may be seen as an additional risk factor. The amount of @entity3 is correlated with @entity4 , but there is no direct correlation with the probability of a @entity2 . Coronary calcification may be measured either by electron beam computed tomography (EBCT) or multi-detector computed tomography (MDCT). OBJECTIVES: The aim of this HTA report is to investigate the diagnostic validity and cost effectiveness of computed tomography techniques in measuring coronary calcification of asymptomatic risk @entity0 . Ethical aspects are discussed. METHODS: A systematic literature research was performed in 35 international databases which yielded 1080 articles. Overall 43 publications were included for assessment, according to predefined selection criteria. RESULTS: Measuring coronary calcification offers additional information compared with traditional risk factors. Yet at present it cannot be said - according to published literature - which population groups gain most. For determining adequate @entity3 score thresholds standardisation for age and sex is important. When comparing the reference standard EBCT with MDCT results are inconsistent and depend on the @entity3 -score value as well as on the scoring method. EBCT as a triage instrument in diagnosing @entity1 appears to be cost-effective. Yet it is rather not cost-effective as a refinement tool for risk stratification. DISCUSSION: Most of the literature was published in the United States and discusses the use of EBCT as well as (traditional) risk stratification by the Framingham Score. Regarding coronary calcification measured by MDCT (which is more widespread in Germany than EBCT) and a risk model applicable for European populations clear recommendations based on published literature cannot be made at present. CONCLUSION: In conclusion measuring coronary calcification is a promising tool for improving risk stratification with established risk models. Nevertheless many questions remain concerning the targeted use in medical practice, particularly regarding European populations. Therefore also no final conclusions can be drawn with respect to cost-effectiveness. The evaluation of diagnostic procedures measuring other parameters than coronary @entity3 with regard to @entity1 risk stratification, compared to EBCT or MDCT, is not part of this report.

title: Computed tomography for the measurement of coronary calcification in asymptomatic risk XXXX .

answer: @entity0


abstract: OBJECTIVE: The goal of this study was to compare the effects of trigger point (TRP) mesotherapy and acupuncture (ACP) mesotherapy in the treatment of @entity0 with @entity2 . DESIGN: Short term randomized controlled trial. SETTING: 62 subjects with @entity2 were recruited at outpatients Physical Medicine and Rehabilitation Clinic at the University of Rome "La Sapienza" in the period between July 2006 and May 2008. INTERVENTION: Study subjects were assigned to receive 4 weeks treatments with either trigger point mesotherapy (TRP mesotherapy, n=29) or acupoints mesotherapy (ACP mesotherapy, n=33). MAIN OUTCOME MEASURES: @entity1 intensity with a @entity1 visual analogic scale (VAS) and verbal rating scale (VRS) and @entity1 with McGill @entity1 Questionnaire Short Form (SFMPQ), Roland Morris Disability Questionnaire (RMQ) and Oswestry Low Back @entity1 Disability Questionaire (ODQ). RESULTS: ACP mesotherapy shows a more effective results in VRS and VAS measures in the follow-up (p(VRS)=<.001 and p(VAS)=<.001). The SF-MPQ measure shows a better results for ACP instead of TRP with statistically significant differences between groups and time (p=.035). @entity0 reported a slight discomfort at the time of the inoculation, and 15% reported slight @entity3 in ACP mesotherapy group. CONCLUSIONS: Our results suggest that the response to ACP mesotherapy may be greater than the response to TRP mesotherapy in the short term follow-up. This technique could be nevertheless a viable option as an adjunct treatment in an overall treatment planning of CLBP.

title: Comparison between the effects of trigger point mesotherapy versus acupuncture points mesotherapy in the treatment of XXXX : a short term randomized controlled trial.

answer: @entity2


abstract: BACKGROUND CONTEXT: Although @entity8 is found in 6% of @entity7 @entity0 , very little was reported on management of pars defects in this group. These @entity0 with @entity1 are most eligible for direct repair of the defect rather than lumbosacral fusion in an attempt to save motion segments. PURPOSE: The aim of this work was to analyze the clinical and radiologic outcome of pars repair in a group of adolescents who presented after surgical correction of their @entity7 . STUDY DESIGN: A prospective nonrandomized study. @entity0 SAMPLE: Ten consecutive @entity0 with @entity8 presenting after an average of 3 months (range, 2-7 months) from correction of their @entity7 with @entity5 not responding to conservative therapy and interfering with everyday activities. The mean age at operation was 16 years (range, 14-19 years). OUTCOME MEASURES: Total @entity2 , operative time, and hospital stay were recorded. Clinical outcome was assessed by the @entity3 Index (ODI), visual analog scale (VAS), and @entity4 ( @entity4 )-22 questionnaire. Fusion of the pars interarticularis was assessed using plain, lateral, and oblique radiographs and a computed tomography (CT) scan. METHODS: The surgical technique consisted of thorough debridement of the defect, impacting the gap created with a tricortical iliac crest graft, and rigid fixation by either pedicle screws and a V-shaped rod (five @entity0 ) or a cable-screw construct (five @entity0 ). RESULTS: @entity0 were followed up for an average of 4.5 years (range, 2-7 years). Nine @entity0 had a good-to-excellent result, returned to normal everyday life, and participated in sports when desired. The mean ODI, VAS, and @entity4 total scores were 11 (range, 0-34), 1.1 (range, 0-2), and 92 (range, 61-108), respectively. Follow-up radiographs and CT scans revealed healing of all defects in nine cases, no signs of @entity6 in any, and no implant-related complications. CONCLUSIONS: The results of direct repair of @entity8 in @entity7 @entity0 were very satisfactory both clinically and radiologically. Direct repair appears to be a logical alternative to spinal fusion; lumbar spine mobility was preserved, and precocious motion segments were saved with a relatively simple operation.

title: Direct repair of XXXX presenting after correction of adolescent @entity7 .

answer: @entity8


abstract: BACKGROUND CONTEXT: Although @entity8 is found in 6% of @entity7 @entity0 , very little was reported on management of pars defects in this group. These @entity0 with @entity1 are most eligible for direct repair of the defect rather than lumbosacral fusion in an attempt to save motion segments. PURPOSE: The aim of this work was to analyze the clinical and radiologic outcome of pars repair in a group of adolescents who presented after surgical correction of their @entity7 . STUDY DESIGN: A prospective nonrandomized study. @entity0 SAMPLE: Ten consecutive @entity0 with @entity8 presenting after an average of 3 months (range, 2-7 months) from correction of their @entity7 with @entity5 not responding to conservative therapy and interfering with everyday activities. The mean age at operation was 16 years (range, 14-19 years). OUTCOME MEASURES: Total @entity2 , operative time, and hospital stay were recorded. Clinical outcome was assessed by the @entity3 Index (ODI), visual analog scale (VAS), and @entity4 ( @entity4 )-22 questionnaire. Fusion of the pars interarticularis was assessed using plain, lateral, and oblique radiographs and a computed tomography (CT) scan. METHODS: The surgical technique consisted of thorough debridement of the defect, impacting the gap created with a tricortical iliac crest graft, and rigid fixation by either pedicle screws and a V-shaped rod (five @entity0 ) or a cable-screw construct (five @entity0 ). RESULTS: @entity0 were followed up for an average of 4.5 years (range, 2-7 years). Nine @entity0 had a good-to-excellent result, returned to normal everyday life, and participated in sports when desired. The mean ODI, VAS, and @entity4 total scores were 11 (range, 0-34), 1.1 (range, 0-2), and 92 (range, 61-108), respectively. Follow-up radiographs and CT scans revealed healing of all defects in nine cases, no signs of @entity6 in any, and no implant-related complications. CONCLUSIONS: The results of direct repair of @entity8 in @entity7 @entity0 were very satisfactory both clinically and radiologically. Direct repair appears to be a logical alternative to spinal fusion; lumbar spine mobility was preserved, and precocious motion segments were saved with a relatively simple operation.

title: Direct repair of @entity8 presenting after correction of adolescent XXXX .

answer: @entity7


abstract: BACKGROUND AND OBJECTIVES: @entity7 ( @entity7 ) is a rare acquired @entity5 characterized by complement-mediated @entity4 , @entity3 and @entity2 . Eculizumab is a humanized monoclonal antibody that blocks the cytolytic component of the complement system by binding to complement C5. MATERIAL AND METHODS: We report the results of eculizumab treatment in 25 @entity7 @entity0 from different centers in Spain. Statistical analysis was perfomed with a SPSS v15.0 software. RESULTS: Fifty-eight per cent of the @entity0 achieved transfusional independence after a median of 14 months. Transfusion requirements were reduced in 60% of the remaining cases. Fatigue resolved in 96% of the @entity0 and smooth muscle dystony-related symptoms in all cases. A single case of treatment-related @entity1 was observed. CONCLUSIONS: Eculizumab controls effectively @entity4 and greatly improves clinical symptoms. The drug is safe and well tolerated, without significant adverse effects except @entity6 . @entity0 with suboptimal response to treatment must be assessed for bone @entity8 and extravascular haemolysis.

title: [ XXXX therapy with eculizumab: Spanish experience].

answer: @entity7


abstract: INTRODUCTION: Our objectives were to characterize sex differences during @entity4 , using the electrolytic inferior vena cava model of the disease. MATERIALS AND METHODS: Male and female C57BL/6 @entity1 (6-8 weeks) underwent @entity6 . Time points included 6 hours, day 2, day 6, and day 14 post surgery, along with surgically na  ve true controls and surgical shams. Analyses included @entity6 weight, vein wall morphometrics, vein wall protein and gene expression for P-selectin, @entity5 , and @entity0 @entity3 factor-a; hematology, soluble P-selectin, and plasma microparticle tissue factor activity assays. RESULTS: Male venous thrombi were significantly larger than females at days 2 (13.1    1.0 vs. 6.8    0.5   10(-3) grams, p < 0.01), 6 (10.4    0.8 vs. 5.4    0.5   10(-3) grams, p < 0.01) and 14 (6.3    0.5 vs. 4.1    0.3   10(-3) grams, p < 0.01). Both male and female @entity1 exhibited significantly increased vein wall P-selectin at 6 hours, vs. true controls (p < 0.05). Males had increased vein wall @entity5 , versus females, at 6 hours (180.926    24.596 vs. 60.417    10.478 pg/mL, p < 0.05) and day 6 (76.966    13.081 vs. 33.834    4.198 pg/mL, p < 0.01). Males showed decreased @entity0 @entity3 factor-a expression (-66 %) at 6 hours. Females had increased @entity0 @entity3 factor-a expression at 6 hours (+541%) and day 6 (+539%). Both sexes demonstrated decreased peripheral platelets at 6 hours (p < 0.05), coinciding with thrombogenesis. Plasma P-selectin increased in both sexes, versus controls, through day 6 (p < 0.05). CONCLUSIONS: Males had significantly larger venous thrombi than females. Sex differences in vascular anatomy and response to @entity2 may influence @entity6 formation in our @entity1 @entity6 model.

title: Male @entity1 have increased thrombotic potential: sex differences in a @entity1 model of XXXX .

answer: @entity4


abstract: INTRODUCTION: Our objectives were to characterize sex differences during @entity4 , using the electrolytic inferior vena cava model of the disease. MATERIALS AND METHODS: Male and female C57BL/6 @entity1 (6-8 weeks) underwent @entity6 . Time points included 6 hours, day 2, day 6, and day 14 post surgery, along with surgically na  ve true controls and surgical shams. Analyses included @entity6 weight, vein wall morphometrics, vein wall protein and gene expression for P-selectin, @entity5 , and @entity0 @entity3 factor-a; hematology, soluble P-selectin, and plasma microparticle tissue factor activity assays. RESULTS: Male venous thrombi were significantly larger than females at days 2 (13.1    1.0 vs. 6.8    0.5   10(-3) grams, p < 0.01), 6 (10.4    0.8 vs. 5.4    0.5   10(-3) grams, p < 0.01) and 14 (6.3    0.5 vs. 4.1    0.3   10(-3) grams, p < 0.01). Both male and female @entity1 exhibited significantly increased vein wall P-selectin at 6 hours, vs. true controls (p < 0.05). Males had increased vein wall @entity5 , versus females, at 6 hours (180.926    24.596 vs. 60.417    10.478 pg/mL, p < 0.05) and day 6 (76.966    13.081 vs. 33.834    4.198 pg/mL, p < 0.01). Males showed decreased @entity0 @entity3 factor-a expression (-66 %) at 6 hours. Females had increased @entity0 @entity3 factor-a expression at 6 hours (+541%) and day 6 (+539%). Both sexes demonstrated decreased peripheral platelets at 6 hours (p < 0.05), coinciding with thrombogenesis. Plasma P-selectin increased in both sexes, versus controls, through day 6 (p < 0.05). CONCLUSIONS: Males had significantly larger venous thrombi than females. Sex differences in vascular anatomy and response to @entity2 may influence @entity6 formation in our @entity1 @entity6 model.

title: Male XXXX have increased thrombotic potential: sex differences in a @entity1 model of @entity4 .

answer: @entity1


abstract: INTRODUCTION: Our objectives were to characterize sex differences during @entity4 , using the electrolytic inferior vena cava model of the disease. MATERIALS AND METHODS: Male and female C57BL/6 @entity1 (6-8 weeks) underwent @entity6 . Time points included 6 hours, day 2, day 6, and day 14 post surgery, along with surgically na  ve true controls and surgical shams. Analyses included @entity6 weight, vein wall morphometrics, vein wall protein and gene expression for P-selectin, @entity5 , and @entity0 @entity3 factor-a; hematology, soluble P-selectin, and plasma microparticle tissue factor activity assays. RESULTS: Male venous thrombi were significantly larger than females at days 2 (13.1    1.0 vs. 6.8    0.5   10(-3) grams, p < 0.01), 6 (10.4    0.8 vs. 5.4    0.5   10(-3) grams, p < 0.01) and 14 (6.3    0.5 vs. 4.1    0.3   10(-3) grams, p < 0.01). Both male and female @entity1 exhibited significantly increased vein wall P-selectin at 6 hours, vs. true controls (p < 0.05). Males had increased vein wall @entity5 , versus females, at 6 hours (180.926    24.596 vs. 60.417    10.478 pg/mL, p < 0.05) and day 6 (76.966    13.081 vs. 33.834    4.198 pg/mL, p < 0.01). Males showed decreased @entity0 @entity3 factor-a expression (-66 %) at 6 hours. Females had increased @entity0 @entity3 factor-a expression at 6 hours (+541%) and day 6 (+539%). Both sexes demonstrated decreased peripheral platelets at 6 hours (p < 0.05), coinciding with thrombogenesis. Plasma P-selectin increased in both sexes, versus controls, through day 6 (p < 0.05). CONCLUSIONS: Males had significantly larger venous thrombi than females. Sex differences in vascular anatomy and response to @entity2 may influence @entity6 formation in our @entity1 @entity6 model.

title: Male @entity1 have increased thrombotic potential: sex differences in a XXXX model of @entity4 .

answer: @entity1


abstract: INTRODUCTION: The aim of this study, performed in an @entity3 ( @entity3 ) population with a normal serum @entity2 , was to estimate urinary @entity2 clearance ( @entity5 ) in a population of @entity4 @entity0 (PT) through a comparison with a population of non @entity1 @entity0 (NPT). METHODS: This was a retrospective, observational study in a medical and surgical @entity3 in a university hospital. A total of 284 @entity0 were consecutively included. Two different groups were studied: PT (n = 144) and NPT (n = 140). Within the second week after admission to the @entity3 , renal function was assessed using serum @entity2 , 24 h urinary @entity5 . RESULTS: Among the 106 @entity0 with a @entity5 above 120 mL minute(-1) 1.73 m(-2), 79 were PT and 27 NPT (P < 0.0001). Only 63 @entity0 had a @entity5 below 60 mL minute(-1) 1.73 m(-2) with 15 PT and 48 NPT (P < 0.0001). @entity0 with @entity5 greater than 120 mL minute(-1). 1.73 m(-2) were younger, had a lower SAPS II score and a higher male ratio as compared to those having @entity5 lower than 120 mL minute(-1). 1.73 m(-2). Through a logistic regression analysis, age and @entity1 were the only factors independently correlated to @entity5 . CONCLUSIONS: In @entity3 @entity0 with normal serum @entity2 , @entity5 , is higher in PT than in NPT. The measure of @entity5 should be proposed as routine for PT @entity0 in order to adjust dose regimen, especially for drugs with renal elimination.

title: Increased @entity2 clearance in XXXX @entity0 with normal serum @entity2 : a retrospective observational study.

answer: @entity4


abstract: INTRODUCTION: The aim of this study, performed in an @entity3 ( @entity3 ) population with a normal serum @entity2 , was to estimate urinary @entity2 clearance ( @entity5 ) in a population of @entity4 @entity0 (PT) through a comparison with a population of non @entity1 @entity0 (NPT). METHODS: This was a retrospective, observational study in a medical and surgical @entity3 in a university hospital. A total of 284 @entity0 were consecutively included. Two different groups were studied: PT (n = 144) and NPT (n = 140). Within the second week after admission to the @entity3 , renal function was assessed using serum @entity2 , 24 h urinary @entity5 . RESULTS: Among the 106 @entity0 with a @entity5 above 120 mL minute(-1) 1.73 m(-2), 79 were PT and 27 NPT (P < 0.0001). Only 63 @entity0 had a @entity5 below 60 mL minute(-1) 1.73 m(-2) with 15 PT and 48 NPT (P < 0.0001). @entity0 with @entity5 greater than 120 mL minute(-1). 1.73 m(-2) were younger, had a lower SAPS II score and a higher male ratio as compared to those having @entity5 lower than 120 mL minute(-1). 1.73 m(-2). Through a logistic regression analysis, age and @entity1 were the only factors independently correlated to @entity5 . CONCLUSIONS: In @entity3 @entity0 with normal serum @entity2 , @entity5 , is higher in PT than in NPT. The measure of @entity5 should be proposed as routine for PT @entity0 in order to adjust dose regimen, especially for drugs with renal elimination.

title: Increased XXXX clearance in @entity4 @entity0 with normal serum @entity2 : a retrospective observational study.

answer: @entity2


abstract: INTRODUCTION: The aim of this study, performed in an @entity3 ( @entity3 ) population with a normal serum @entity2 , was to estimate urinary @entity2 clearance ( @entity5 ) in a population of @entity4 @entity0 (PT) through a comparison with a population of non @entity1 @entity0 (NPT). METHODS: This was a retrospective, observational study in a medical and surgical @entity3 in a university hospital. A total of 284 @entity0 were consecutively included. Two different groups were studied: PT (n = 144) and NPT (n = 140). Within the second week after admission to the @entity3 , renal function was assessed using serum @entity2 , 24 h urinary @entity5 . RESULTS: Among the 106 @entity0 with a @entity5 above 120 mL minute(-1) 1.73 m(-2), 79 were PT and 27 NPT (P < 0.0001). Only 63 @entity0 had a @entity5 below 60 mL minute(-1) 1.73 m(-2) with 15 PT and 48 NPT (P < 0.0001). @entity0 with @entity5 greater than 120 mL minute(-1). 1.73 m(-2) were younger, had a lower SAPS II score and a higher male ratio as compared to those having @entity5 lower than 120 mL minute(-1). 1.73 m(-2). Through a logistic regression analysis, age and @entity1 were the only factors independently correlated to @entity5 . CONCLUSIONS: In @entity3 @entity0 with normal serum @entity2 , @entity5 , is higher in PT than in NPT. The measure of @entity5 should be proposed as routine for PT @entity0 in order to adjust dose regimen, especially for drugs with renal elimination.

title: Increased @entity2 clearance in @entity4 @entity0 with normal serum XXXX : a retrospective observational study.

answer: @entity2


abstract: INTRODUCTION: The aim of this study, performed in an @entity3 ( @entity3 ) population with a normal serum @entity2 , was to estimate urinary @entity2 clearance ( @entity5 ) in a population of @entity4 @entity0 (PT) through a comparison with a population of non @entity1 @entity0 (NPT). METHODS: This was a retrospective, observational study in a medical and surgical @entity3 in a university hospital. A total of 284 @entity0 were consecutively included. Two different groups were studied: PT (n = 144) and NPT (n = 140). Within the second week after admission to the @entity3 , renal function was assessed using serum @entity2 , 24 h urinary @entity5 . RESULTS: Among the 106 @entity0 with a @entity5 above 120 mL minute(-1) 1.73 m(-2), 79 were PT and 27 NPT (P < 0.0001). Only 63 @entity0 had a @entity5 below 60 mL minute(-1) 1.73 m(-2) with 15 PT and 48 NPT (P < 0.0001). @entity0 with @entity5 greater than 120 mL minute(-1). 1.73 m(-2) were younger, had a lower SAPS II score and a higher male ratio as compared to those having @entity5 lower than 120 mL minute(-1). 1.73 m(-2). Through a logistic regression analysis, age and @entity1 were the only factors independently correlated to @entity5 . CONCLUSIONS: In @entity3 @entity0 with normal serum @entity2 , @entity5 , is higher in PT than in NPT. The measure of @entity5 should be proposed as routine for PT @entity0 in order to adjust dose regimen, especially for drugs with renal elimination.

title: Increased @entity2 clearance in @entity4 XXXX with normal serum @entity2 : a retrospective observational study.

answer: @entity0


abstract: BACKGROUND: A worldwide outbreak of @entity2 flu H1N1 pandemic @entity1 occurred in April 2009. To determine the mechanism underlying the spread of infection, we prospectively evaluated a survey implemented at a local university. METHODS: Between August 2009 and March 2010, we surveyed 3 groups of subjects: 2318 @entity0 in six schools attached to the Faculty of Education, 11424 university students, and 3344 staff members. Subjects with @entity1 -like symptoms who were diagnosed with @entity2 flu at hospitals or clinics were defined as @entity2 flu @entity0 and asked to make a report using a standardized form. RESULTS: After the start of the pandemic, a total of 2002 @entity0 (11.7%) were registered in the survey. These @entity0 included 928 schoolchildren (40.0%), 1016 university students (8.9%), and 58 staff members (1.7%). The incidence in schoolchildren was significantly higher than in the other 2 groups (P < 0.0001) but there were no within group differences in incidence rate between males and females. During the period of the survey, three peaks of @entity0 numbers were observed, in November 2009, December 2009, and January 2010. The first peak consisted mainly of schoolchildren, whereas the second and third peaks included many university students. Staff members did not contribute to peak formation. Among the university students, the most common suspected route of transmission was club activity. Interventions, such as closing classes, schools, and clubs, are likely to affect the epidemic curves. CONCLUSION: Schoolchildren and university students are vulnerable to @entity2 flu, suggesting that avoidance of close contact, especially among these young @entity0 , may be effective way in controlling future severe @entity1 pandemics, especially at educational institutions.

title: XXXX -origin @entity1 a outbreak 2009 at Shinshu University, Japan.

answer: @entity2


abstract: BACKGROUND: A worldwide outbreak of @entity2 flu H1N1 pandemic @entity1 occurred in April 2009. To determine the mechanism underlying the spread of infection, we prospectively evaluated a survey implemented at a local university. METHODS: Between August 2009 and March 2010, we surveyed 3 groups of subjects: 2318 @entity0 in six schools attached to the Faculty of Education, 11424 university students, and 3344 staff members. Subjects with @entity1 -like symptoms who were diagnosed with @entity2 flu at hospitals or clinics were defined as @entity2 flu @entity0 and asked to make a report using a standardized form. RESULTS: After the start of the pandemic, a total of 2002 @entity0 (11.7%) were registered in the survey. These @entity0 included 928 schoolchildren (40.0%), 1016 university students (8.9%), and 58 staff members (1.7%). The incidence in schoolchildren was significantly higher than in the other 2 groups (P < 0.0001) but there were no within group differences in incidence rate between males and females. During the period of the survey, three peaks of @entity0 numbers were observed, in November 2009, December 2009, and January 2010. The first peak consisted mainly of schoolchildren, whereas the second and third peaks included many university students. Staff members did not contribute to peak formation. Among the university students, the most common suspected route of transmission was club activity. Interventions, such as closing classes, schools, and clubs, are likely to affect the epidemic curves. CONCLUSION: Schoolchildren and university students are vulnerable to @entity2 flu, suggesting that avoidance of close contact, especially among these young @entity0 , may be effective way in controlling future severe @entity1 pandemics, especially at educational institutions.

title: @entity2 -origin XXXX a outbreak 2009 at Shinshu University, Japan.

answer: @entity1


abstract: BACKGROUND: @entity7 ( @entity7 ) presents clinically as waxy yellow-brown plaques, commonly on the shins. @entity6 also involves the legs; however, it has distinct clinical and pathologic features. OBJECTIVE: We present a series of eight @entity0 who had lesions that clinically resembled @entity7 but on pathology showed features resembling @entity6 . METHODS: Between 1997 and 2008, eight @entity0 were identified at St. Paul's Hospital, Vancouver, to have had @entity3 clinically diagnosed as @entity7 , or a similar morphologic entity, but showing histopathologic features resembling @entity6 on biopsy. The clinical records and pathology reports of these @entity0 were reviewed. RESULTS: The @entity0 ' ages ranged from 39 to 73 years. Only one @entity0 was female. Members of the group held diagnoses of @entity1 , @entity2 , or @entity4 . All @entity0 had lesions on the legs, most on the anterior aspect. The clinical diagnosis was generally @entity7 ; other clinical impressions included @entity8 , and @entity5 . All @entity0 had features on pathology resembling @entity6 and no features of @entity7 . CONCLUSION: We propose that this unique combination of clinical features of @entity7 and histopathologic features resembling @entity6 represents a novel entity for which we propose the name pretibial angioplasia.

title: Pretibial angioplasia: a novel entity encompassing the clinical features of XXXX and the histopathology of @entity6 .

answer: @entity7


abstract: BACKGROUND: @entity7 ( @entity7 ) presents clinically as waxy yellow-brown plaques, commonly on the shins. @entity6 also involves the legs; however, it has distinct clinical and pathologic features. OBJECTIVE: We present a series of eight @entity0 who had lesions that clinically resembled @entity7 but on pathology showed features resembling @entity6 . METHODS: Between 1997 and 2008, eight @entity0 were identified at St. Paul's Hospital, Vancouver, to have had @entity3 clinically diagnosed as @entity7 , or a similar morphologic entity, but showing histopathologic features resembling @entity6 on biopsy. The clinical records and pathology reports of these @entity0 were reviewed. RESULTS: The @entity0 ' ages ranged from 39 to 73 years. Only one @entity0 was female. Members of the group held diagnoses of @entity1 , @entity2 , or @entity4 . All @entity0 had lesions on the legs, most on the anterior aspect. The clinical diagnosis was generally @entity7 ; other clinical impressions included @entity8 , and @entity5 . All @entity0 had features on pathology resembling @entity6 and no features of @entity7 . CONCLUSION: We propose that this unique combination of clinical features of @entity7 and histopathologic features resembling @entity6 represents a novel entity for which we propose the name pretibial angioplasia.

title: Pretibial angioplasia: a novel entity encompassing the clinical features of @entity7 and the histopathology of XXXX .

answer: @entity6


abstract: A single, 68,000 m.w. glycoprotein antigen from adult @entity2 was purified by immunoaffinity chromatography with the use of a newly developed, protective, anti-schistosome murine monoclonal antibody. Immunization with two doses of 0.5 microgram or 1 microgram of purified antigen, without adjuvants, afforded a mean 28% reduction in parasite recovery in CF1 @entity0 , and 2-% reduction in parasite BALB/c @entity0 . On immunoblotting, the 68,000 m.w. antigen was common to @entity3 adults and schistosomula, whereas parasite eggs contained only cross-reacting low m.w. antigens of 19,100 and 16,000. Immunization resulted in the development of anti-antigen antibody and enhanced immediate cutaneous @entity1 to the 31-3B6 antigen. By contrast, @entity1 and sensitization to circumoval @entity4 formation were not observed in immunized @entity0 . It was concluded that the 68,000 m.w. 31-3B6 antigen represents a candidate vaccine for adjuvant-free immunization against @entity3 .

title: Isolation and characterization of a protective antigen for adjuvant-free immunization against XXXX .

answer: @entity2