abstract: BACKGROUND: This retrospective cohort study evaluated whether @entity4 ( @entity4 ) therapy increases the risk of recurrence of @entity0 . METHODS: We analyzed 1,106 @entity1 who were diagnosed with stage 0-3 @entity0 between 2007 and 2011 and experienced remission after surgery and adjuvant therapy. The @entity1 were divided into two groups: group A (n=996), in which @entity1 did not participate in any @entity4 therapy, regardless of whether they developed @entity0 ( @entity0 ) after @entity3 treatment; and group B (n=110), in which @entity1 participated in @entity4 therapy for @entity0 . All @entity1 were monitored until October 2013 to determine whether @entity0 recurrence developed, including local or regional recurrence and distant @entity2 . @entity1 who developed @entity3 recurrence prior to @entity4 therapy were excluded from analysis. Risk factors associated with @entity3 recurrence were evaluated using Cox proportional hazards models. RESULTS: During the monitoring period, 166 @entity1 (15.0%) developed @entity3 recurrence, including 154 (15.5%) in group A and 12 (10.9%) in group B. The median period from surgery to @entity3 recurrence was 1.85 (interquartile range 1.18-2.93) years. Independent risk factors for @entity3 recurrence were @entity3 histological grading of grade 3, high number (>= 3) of axillary lymph node invasion, and a large @entity3 size (>5 cm). Factors protecting against recurrence were positive @entity5 status and receiving radiation therapy. Receiving @entity4 therapy was not an outcome factor in multivariate analyses (hazard ratio 0.71, 95% confidence interval 0.39-1.29, P=0.259). CONCLUSION: @entity4 is a gentle procedure that does not increase the risk of @entity0 recurrence in @entity1 who develop @entity0 .

title: Risk of @entity0 recurrence in XXXX receiving @entity4 : a hospital-based cohort study.

answer: @entity1


abstract: BACKGROUND: In this study we used cellular magnetic resonance imaging (MRI) to detect mesenchymal stem cells (MSC) labeled with a @entity1 -19 (19F) agent. 19F-MRI offers unambiguous detection and in vivo quantification of labeled cells. METHODS: We investigated two common stem cell transplant @entity0 models: an immune competent, syngeneic transplant model and an immune compromised, xenograft transplant model. 19F labelled stem cells were implanted intramuscularly into the hindlimb of healthy @entity0 . The transplant was then monitored for up to 17 days using 19F-MRI, after which the tissue was excised for fluorescence microscopy and immunohistochemisty. RESULTS: Immediately following transplantation, 19F-MRI quantification correlated very well with the expected cell number in both models. The 19F signal decreased over time in both models, with a more rapid decrease in the syngeneic model. By endpoint, only 2/7 syngeneic @entity0 had any detectable 19F signal. In the xenograft model, all @entity0 had detectable signal at endpoint. Fluorescence microscopy and immunohistochemistry were used to show that the 19F signal was related to the presence of bystander labeled macrophages, and not original MSC. CONCLUSIONS: Our results show that 19F-MRI is an excellent tool for verifying the delivery of therapeutic cells early after transplantation. However, in certain circumstances the transfer of cellular label to other bystander cells may confuse interpretation of the long-term fate of the transplanted cells.

title: Tracking the Fate of Stem Cell Implants with XXXX -19 MRI.

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) is associated with an increased risk for medical comorbidities that may prevent participation in psychotherapy. The present study investigated whether medical comorbidities were associated with lower initiation rates and fewer psychotherapy visits for @entity1 . Because @entity0 are more likely to initiate psychotherapy after traumatic events, we also assessed whether relationships were weaker among @entity0 . METHODS: Veterans (N=482, 47% @entity0 ) recently diagnosed with @entity1 completed a survey assessing demographics, mood, functional status, and interest in treatment. Data on medical comorbidities, psychotherapy visits, antidepressant prescriptions, and service connection were assessed longitudinally through administrative files. Logistic and negative binomial regressions assessed associations between number of medical comorbidities in the 2 years before the survey and the initiation and number of psychotherapy visits for @entity1 in the year after the survey. All analyses were stratified by sex and controlled for survey and administrative variables. RESULTS: The relationship between medical comorbidities and number of psychotherapy visits was stronger among @entity0 than among @entity0 . A greater number of medical comorbidities was associated with significantly fewer psychotherapy visits in the total sample [incidence rate ratio: 0.91; 95% confidence interval (CI): 0.83, 1.00] and among @entity0 (incidence rate ratio: 0.87; 95% CI: 0.77, 0.99), but not among @entity0 (95% CI: 0.75, 1.01). Medical comorbidities were not associated with the initiation of psychotherapy among @entity0 or @entity0 . CONCLUSIONS: Addressing medical comorbidities may help individuals remain in psychotherapy for @entity1 . Medical comorbidities may play a larger role in the number of psychotherapy visits among @entity0 than @entity0 .

title: The Effect of Medical Comorbidities on Male and Female Veterans' Use of Psychotherapy for XXXX .

answer: @entity1


abstract: UNASSIGNED: Ultrasound (US) is widely used in rheumatology to study and guide injection of peripheral joints. It can also provide useful information about the anatomy of the lumbar spine. Studies have shown that US examination of the spine was a useful tool to help perform epidural anaesthesia. The purpose of the study was to determine if the selection of the optimum puncture level by US may facilitate epidural @entity2 injection in case of presumed difficult puncture (BMI>30kg/m(2), age>60years or @entity4 ). METHODS: We performed a prospective randomized controlled study. Eighty @entity0 were randomized in two groups: US group (n=40) which underwent a pre-procedure spinal US to determine the optimal lumbar level for injection or control group (n=40) for which the level of injection was determined by palpation. Primary endpoint was the @entity3 during the procedure assessed using the Visual Analogue Scale (VAS). RESULTS: We found a positive correlation between depth of the epidural space and BMI (P<0.001) and a negative correlation between size of the interspinous spaces and age (P<0.01). Visibility of the epidural space was not altered by @entity1 or age. We observed a trend toward a reduction in @entity3 intensity during the procedure in the US group compared to the control group with a mean difference at -0.94 [-1.90; 0.02] but the difference was not significant (P=0.054). CONCLUSION: US of the lumbar spine was feasible in @entity0 with lumbar conditions even in @entity1 and old ones and allowed the visualization of the epidural space. However, pre-procedure US examination did not reduce @entity3 during the procedure.

title: Usefulness of a pre-procedure ultrasound scanning of the lumbar spine before epidural injection in XXXX with a presumed difficult puncture: A randomized controlled trial.

answer: @entity0


abstract: OBJECTIVE: To study the clinical diagnosis and preoperative management of @entity4 . METHODS: A total of 24 cases with @entity4 underwent surgery from 2003 to 2013 were reviewed. The clinical and imaging features, treatment and prognosis were retrospectively evaluated. Five of the 24 @entity0 were males and 19 were females. Twenty-three cases were benign and one case was malignant. Seven of the 24 @entity0 had @entity1 . RESULTS: Nineteen of twenty-four @entity0 underwent digital subtraction angiography (DSA) and @entity2 ( @entity2 ) test, and one case of them was positive in the test. Twenty-three benign case were treated with operation. The malignant one treat with biopsy. Three cases underwent resection of @entity1 with both the internal and external carotid arteries without carotid reconstruction, and none of the three @entity0 died or presented with @entity3 after operation. Twenty-three benign cases were followed up for 6-122 months, the median was 75 months. The malignant @entity0 died 6 months after operation. CONCLUSION: @entity2 and DSA are reliable and practical methods to determine the safety of carotid ligation and can be used as routine preoperative examinations.

title: [Clinical analysis of 24 cases of XXXX ].

answer: @entity4


abstract: OBJECTIVE: Heat is a sign and symptom of @entity2 in wound assessment criteria but there is currently no diagnostic tool being used in clinical practice to assess the skin temperature of surgical wounds. Using thermal imaging, the objective of this study was to map the temperature of the healing surgical wound and to provide confirmatory data of: a) optimum IR imaging distance from skin temperature target field of view (FOV) b) body composition effects on abdominal skin surface temperature readings c) thermal mapping characteristics of @entity1 wounds post stoma-closure. METHOD: The abdominal skin surface temperature of healthy, afebrile subjects was measured under controlled, ambient conditions in a small (240cm x 320cm) clinical room. Subject standing positions were 30cm, 60cm and 100cm from the IR camera. Abdominal skin surface temperature and thermal imaging maps were acquired in a population of surgical @entity0 before and after closure of enterostoma. RESULTS: Subjects (30) aged 19-52 (median=29) years were recruited. At a distance of 100cm, each of nine anatomical regions showed a decrease in mean temperature as BMI increased. Subjects with BMI >25 had lower mean abdominal temperatures. Statistically significant differences were observed for right hypochondrium (p=0.022), left lumbar region (p=0.009), right lumbar region (p=0.010) and the umbilical region (p=0.021). Half of @entity0 (5/10) developed @entity2 . CONCLUSION: Within the operating distances investigated, no significant effect on abdominal temperature readings was observed. With increasing BMI, lower abdominal temperatures were noted. The thermal pattern of abdominal surgical wounds reveals some differences between the healing and infected wound. Healing wounds showed changes in the thermal 'map'; an increase in temperature on the first post-operative day, and 'warming' over the subsequent five days. 'Cold spots' emerged on the thermogram of the surgical wounds which subsequently were shown to be infected. Within the setting of a clinical environment, distances up to 100cm did not significantly alter skin temperature readings within the FOV. There is a suggestion that body composition influences skin temperature. @entity2 appear 'colder' than healing wounds. DECLARATION OF INTEREST: The authors have no conflict or interest. The work was supported by a grant from the SingHealth Foundation.

title: Thermographic mapping of the abdomen in healthy subjects and XXXX after enterostoma.

answer: @entity0


abstract: OBJECTIVES: We aimed to assess the efficacy of greater occipital nerve (GON) blockade at @entity3 ( @entity3 ) treatment. MATERIALS AND METHODS: @entity0 with @entity3 were randomly divided into two groups of 42. GON blockade was administered four times (once per week) with saline in group A or bupivacaine in group B. After 4  weeks of treatment, blinding was removed; in group A, GON blockade was achieved using bupivacaine, while group B continued to receive bupivacaine, and blockade was administered once per month, then followed for 2  months. Primary endpoint was the difference in number of @entity1 days, duration of @entity1 , and @entity2 scores. RESULTS: Seventy-two of 84 @entity0 completed the study. After 1  month of treatment, number of @entity1 days had decreased from 16.9      5.7 to 13.2      6.7 in group A (P  =  0.035) and from 18.1      5.3 to 8.8      4.8 in group B (P  <  0.001), (P  =  0.004, between groups); duration of @entity1 (hour) had decreased from 24.2      13.7 to 21.2      13.4 in group A (P  =  0.223) and from 25.9      16.3 to 19.3      11.5 in group B (P  <  0.001), (P  =  0.767, between groups). VAS score decreased from 8.1      0.9 to 6.7      1.6 in group A (P  =  0.002) and from 8.4      1.5 to 5.3      2.1 in group B (P  <  0.001), (P  =  0.004, between groups). After blinding was removed (in 2nd and 3rd month), group A exhibited similar results like group B in 3rd month. CONCLUSIONS: Our results suggest that GON blockade with bupivacaine was superior to placebo and was found to be effective, safe, and cost-effective for the treatment of @entity3 . According to our knowledge, this is the first randomized, multicentre, double-blind, and placebo-controlled study in the literature in this field of work.

title: Greater occipital nerve blockade for the treatment of XXXX : a randomized, multicenter, double-blind, and placebo-controlled study.

answer: @entity3


abstract: UNASSIGNED: @entity4 ( @entity4 ) is associated with a reduction in the numbers of nephrons in neonates, which increases the risk of @entity2 . Our previous study showed that @entity6 protects the development of the embryonic kidney during @entity4 . To explore this molecular mechanism, @entity4 @entity1 were induced by protein and calorie restriction throughout pregnancy, and @entity6 was delivered using a mini osmotic pump. RNA sequencing technology was used to identify the differentially expressed genes (DEGs) of the @entity0 . DEGs were submitted to the Database for Annotation and Visualization and Integrated Discovery, and gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted. @entity5 significantly reduced fetal weight, but @entity6 treatment had no significant effect on body weight. A total of 322 (177 upregulated and 145 downregulated) DEGs were detected between control and the @entity4 group. Meanwhile, 318 DEGs were found to be differentially expressed (180 increased and 138 decreased) between the @entity4 group and the @entity6 -treated group. KEGG pathway analysis indicated that maternal undernutrition mainly disrupts the complement and coagulation cascades and the @entity3 signaling pathway, which could be protected by @entity6 treatment. Taken together, these two biological pathways may play an important role in nephrogenesis, indicating potential novel therapeutic targets against the unfavorable effects of @entity4 .

title: XXXX rescues @entity1 nephrogenesis during intrauterine growth restriction by regulating the complement and coagulation cascades and @entity3 signaling pathway.

answer: @entity6


abstract: UNASSIGNED: @entity4 ( @entity4 ) is associated with a reduction in the numbers of nephrons in neonates, which increases the risk of @entity2 . Our previous study showed that @entity6 protects the development of the embryonic kidney during @entity4 . To explore this molecular mechanism, @entity4 @entity1 were induced by protein and calorie restriction throughout pregnancy, and @entity6 was delivered using a mini osmotic pump. RNA sequencing technology was used to identify the differentially expressed genes (DEGs) of the @entity0 . DEGs were submitted to the Database for Annotation and Visualization and Integrated Discovery, and gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted. @entity5 significantly reduced fetal weight, but @entity6 treatment had no significant effect on body weight. A total of 322 (177 upregulated and 145 downregulated) DEGs were detected between control and the @entity4 group. Meanwhile, 318 DEGs were found to be differentially expressed (180 increased and 138 decreased) between the @entity4 group and the @entity6 -treated group. KEGG pathway analysis indicated that maternal undernutrition mainly disrupts the complement and coagulation cascades and the @entity3 signaling pathway, which could be protected by @entity6 treatment. Taken together, these two biological pathways may play an important role in nephrogenesis, indicating potential novel therapeutic targets against the unfavorable effects of @entity4 .

title: @entity6 rescues @entity1 nephrogenesis during intrauterine growth restriction by regulating the complement and coagulation cascades and XXXX signaling pathway.

answer: @entity3


abstract: UNASSIGNED: @entity4 ( @entity4 ) is associated with a reduction in the numbers of nephrons in neonates, which increases the risk of @entity2 . Our previous study showed that @entity6 protects the development of the embryonic kidney during @entity4 . To explore this molecular mechanism, @entity4 @entity1 were induced by protein and calorie restriction throughout pregnancy, and @entity6 was delivered using a mini osmotic pump. RNA sequencing technology was used to identify the differentially expressed genes (DEGs) of the @entity0 . DEGs were submitted to the Database for Annotation and Visualization and Integrated Discovery, and gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were conducted. @entity5 significantly reduced fetal weight, but @entity6 treatment had no significant effect on body weight. A total of 322 (177 upregulated and 145 downregulated) DEGs were detected between control and the @entity4 group. Meanwhile, 318 DEGs were found to be differentially expressed (180 increased and 138 decreased) between the @entity4 group and the @entity6 -treated group. KEGG pathway analysis indicated that maternal undernutrition mainly disrupts the complement and coagulation cascades and the @entity3 signaling pathway, which could be protected by @entity6 treatment. Taken together, these two biological pathways may play an important role in nephrogenesis, indicating potential novel therapeutic targets against the unfavorable effects of @entity4 .

title: @entity6 rescues XXXX nephrogenesis during intrauterine growth restriction by regulating the complement and coagulation cascades and @entity3 signaling pathway.

answer: @entity1


abstract: UNASSIGNED: Basal cell @entity2 and @entity1 show marked histomorphologic similarity and are separated microscopically primarily by the invasive characteristics of the @entity1 . We wished to explore potential differences in the expression of epithelial-mesenchymal transition associated proteins in these two @entity0 types. A tissue microarray was constructed utilizing 29 basal cell @entity2 and 16 @entity1 . Immunohistochemical expression of @entity5 , @entity4 , @entity6 and @entity3 were investigated. Both @entity0 expressed all proteins in a relatively similar manner. Nuclear @entity4 was essentially limited to the abluminal cell populations in both @entity0 types. @entity5 was limited largely to luminal locations but was more prevalent in the @entity1 as compared to the @entity2 . Primarily abluminal expression for @entity3 was seen, sometimes present in an apical dot-like pattern. Distinct populations of cellular expression of these four markers of epithelial mesenchymal transition were present but were similar in locations in both @entity0 with no patterns discerned to separate basal cell adenoma from @entity1 . Given these findings, the mechanisms by which @entity1 is able to invade while its counterpart, basal cell adenoma can not, may be more complex than in other @entity0 types.

title: Epithelial-Mesenchymal Transition Protein Expression in Basal Cell XXXX .

answer: @entity2


abstract: OBJECTIVE: To examine changes in @entity1 mortality in 34 European countries between 1970 and 2011. DESIGN: Retrospective trend analysis. DATA SOURCE: World Health Organization mortality database. POPULATION: Deaths from @entity1 between 1970 and 2011. Profound changes in screening and treatment efficiency took place after 1988; therefore, particular attention was paid to the evolution of @entity1 mortality in the subsequent period. MAIN OUTCOMES MEASURES: Time trends in rates of @entity1 mortality, using joinpoint regression analysis. Rates were age adjusted using the standard European population. RESULTS: From 1989 to 2011, @entity1 mortality increased by a median of 6.0% for @entity0 and decreased by a median of 14.7% for @entity0 in the 34 European countries. Reductions in @entity1 mortality of more than 25% in @entity0 and 30% in @entity0 occurred in Austria, Switzerland, Germany, the United Kingdom, Belgium, the Czech Republic, Luxembourg, and Ireland. By contrast, mortality rates fell by less than 17% in the Netherlands and Sweden for both sexes. Over the same period, smaller or no declines occurred in most central European countries. Substantial mortality increases occurred in Croatia, the former Yugoslav republic of Macedonia, and Romania for both sexes and in most eastern European countries for @entity0 . In countries with decreasing mortality, reductions were more important for @entity0 of all ages and @entity0 younger than 65 years. In the 27 European Union member states, @entity1 mortality fell by 13.0% in @entity0 and 27.0% in @entity0 , compared with corresponding reductions of 39.8% and 38.8% in the United States. CONCLUSION: Over the past 40 years, there has been considerable disparity in the level of @entity1 mortality between European countries, as well as between @entity0 and @entity0 and age categories. Countries with the largest reductions in @entity1 mortality are characterised by better accessibility to screening services, especially endoscopic screening, and specialised care.

title: Trends in XXXX mortality in Europe: retrospective analysis of the WHO mortality database.

answer: @entity1


abstract: INTRODUCTION AND OBJECTIVES: We present the results of the Spanish Implantable Cardioverter-defibrillator Registry for 2014, as compiled by the Electrophysiology and @entity5 Section of the Spanish Society of Cardiology. METHODS: Data collection sheets were voluntarily completed by each implantation team and prospectively sent to the Spanish Society of Cardiology. RESULTS: The number of reported implantations was 4911 (82% of the estimated total number of implantations). The implantation rate was 106 per million population while the estimated rate was 128. First implantations comprised 72.2%. Data were obtained from 162 hospitals (8 more than in 2013). Most implantations (82%) were performed in @entity0 . The mean @entity0 age was 61.8  13.7 years. Most @entity0 showed severe or moderate-to-severe @entity1 and were in New York Heart Association functional class II. The most frequent @entity2 was @entity4 , followed by @entity3 . Implantations for primary prevention indications comprised 58.5%. Electrophysiologists performed 85.6% of the implantations. CONCLUSIONS: The 2014 Spanish Implantable Cardioverter-defibrillator Registry received information on 82% of the implantations performed in Spain. The number of implantations has increased from previous years and the percentage of implantations for primary prevention indications has increased from the previous year.

title: Spanish Implantable Cardioverter-defibrillator Registry. Eleventh Official Report of the Spanish Society of Cardiology Electrophysiology and XXXX Section (2014).

answer: @entity5


abstract: BACKGROUND: The FAST (food @entity6 -specific immunotherapy) project aims at developing safe and effective subcutaneous immunotherapy for @entity9 , using recombinant hypoallergenic @entity8 @entity12 , @entity11 @entity7 . OBJECTIVES: Preclinical characterization and good manufacturing practice (GMP) production of mutant @entity11 (mCyp) @entity7 . METHODS: @entity5 -produced mCyp @entity7 was purified using standard chromatographic techniques. Physicochemical properties were investigated by gel electrophoresis, size exclusion chromatography, circular dichroism spectroscopy, reverse-phase high-performance liquid chromatography and mass spectrometry. Allergenicity was assessed by ImmunoCAP inhibition and basophil @entity3 release assay, immunogenicity by immunization of laboratory animals and stimulation of @entity0 ' peripheral blood mononuclear cells (PBMCs). Reference molecules were purified wild-type @entity11 @entity7 (natural and/or recombinant). GMP-compliant alum-adsorbed mCyp @entity7 was tested for acute @entity4 in @entity1 and @entity2 and for repeated-dose @entity4 in @entity1 . Accelerated and real-time protocols were used to evaluate stability of mCyp @entity7 as drug substance and drug product. RESULTS: Purified mCyp @entity7 behaves as a folded and stable molecule. Using sera of 26 double-blind placebo-controlled food-challenge-proven fish-allergic @entity0 , reduction in allergenic activity ranged from 10- to 5,000-fold (1,000-fold on average), but with retained immunogenicity (immunization in @entity1 / @entity2 ) and potency to stimulate @entity0 PBMCs. @entity4 studies revealed no toxic effects and real-time stability studies on the @entity10 -adsorbed drug product demonstrated at least 20 months of stability. CONCLUSION: The GMP drug product developed for treatment of @entity9 has the characteristics targeted for in FAST: i.e. hypoallergenicity with retained immunogenicity. These results have warranted first-in- @entity0 immunotherapy studies to evaluate the safety of this innovative vaccine.    2015 S. Karger AG, Basel.

title: Development of a Hypoallergenic Recombinant XXXX for First-in- @entity0 Subcutaneous Immunotherapy of Fish Allergy.

answer: @entity12


abstract: BACKGROUND: The FAST (food @entity6 -specific immunotherapy) project aims at developing safe and effective subcutaneous immunotherapy for @entity9 , using recombinant hypoallergenic @entity8 @entity12 , @entity11 @entity7 . OBJECTIVES: Preclinical characterization and good manufacturing practice (GMP) production of mutant @entity11 (mCyp) @entity7 . METHODS: @entity5 -produced mCyp @entity7 was purified using standard chromatographic techniques. Physicochemical properties were investigated by gel electrophoresis, size exclusion chromatography, circular dichroism spectroscopy, reverse-phase high-performance liquid chromatography and mass spectrometry. Allergenicity was assessed by ImmunoCAP inhibition and basophil @entity3 release assay, immunogenicity by immunization of laboratory animals and stimulation of @entity0 ' peripheral blood mononuclear cells (PBMCs). Reference molecules were purified wild-type @entity11 @entity7 (natural and/or recombinant). GMP-compliant alum-adsorbed mCyp @entity7 was tested for acute @entity4 in @entity1 and @entity2 and for repeated-dose @entity4 in @entity1 . Accelerated and real-time protocols were used to evaluate stability of mCyp @entity7 as drug substance and drug product. RESULTS: Purified mCyp @entity7 behaves as a folded and stable molecule. Using sera of 26 double-blind placebo-controlled food-challenge-proven fish-allergic @entity0 , reduction in allergenic activity ranged from 10- to 5,000-fold (1,000-fold on average), but with retained immunogenicity (immunization in @entity1 / @entity2 ) and potency to stimulate @entity0 PBMCs. @entity4 studies revealed no toxic effects and real-time stability studies on the @entity10 -adsorbed drug product demonstrated at least 20 months of stability. CONCLUSION: The GMP drug product developed for treatment of @entity9 has the characteristics targeted for in FAST: i.e. hypoallergenicity with retained immunogenicity. These results have warranted first-in- @entity0 immunotherapy studies to evaluate the safety of this innovative vaccine.    2015 S. Karger AG, Basel.

title: Development of a Hypoallergenic Recombinant @entity12 for First-in- XXXX Subcutaneous Immunotherapy of Fish Allergy.

answer: @entity0


abstract: UNASSIGNED: The purpose of this study was to compare the postoperative stability following bimaxillary surgery performed either with or without preoperative orthodontic treatment, in @entity1 @entity0 . These @entity0 were enrolled using standardized inclusion criteria. Forty @entity0 with a @entity1 were included in this retrospective study. Inclusion criteria were @entity1 with and without premolar extraction, <3mm midline deviation, and <5mm arch width discordance. @entity0 were assigned to the conventional bimaxillary surgery group (n=20) or the surgery-first bimaxillary surgery group (n=20). Serial cephalometric radiographs obtained before surgery (T0), at 2 months after surgery (T1), and at 6 months after surgery (T2) were used to assess the variation in surgical change (T0 to T1) and postsurgical change (T1 to T2). Eight linear and three angular parameters were used to evaluate postoperative stability. With respect to postsurgical changes, significant differences were observed in the changes for the vertical reference plane to the posterior nasal spine, horizontal reference plane to B-point, and occlusal plane angle in both groups. No statistically significant differences in the relapse rates were observed between the two groups. No significant differences were observed between the two groups in terms of the postoperative stability.

title: Skeletal stability of surgery-first bimaxillary orthognathic surgery for skeletal XXXX , using standardized criteria.

answer: @entity1


abstract: BACKGROUND: Approximately 6000 @entity0 are born with CHD in Germany each year. It is increasingly rare that these @entity0 die from their @entity1 . In the present study, data recorded in the National Register for @entity2 with respect to the prevalence of specific lesions and sex distribution are compared with that recorded in a published German prevalence study (Prevalence Study) and with the meta-analysis by van der Linde et al. METHODS: A descriptive data analysis was performed using a minimal data set. The demographic data included sex and birth year; the medical data comprised the cardiovascular diagnosis according to the short list of the International Paediatric and Congenital Cardiac Code. RESULTS: As the data analysis shows, the National Register is a clinical register including primarily clinical cases/cases relevant to healthcare. The prevalence values and sex ratios recorded in the register are closer to the values given in the literature than those determined by the Prevalence Study. Severe CHD was slightly over-represented in the National Register compared with the van der Linde et al meta-analysis. The deviations with respect to prevalence values are within an acceptable range. CONCLUSION: With its 48,000 @entity0 , the National Register plays a unique and important role for research in the field of CHD. Samples from the National Register can be used as a gold standard for future studies, as the @entity0 population registered in it can be considered representative of CHD in Germany and Europe.

title: Representativeness of the German National Register for XXXX : a clinically oriented analysis.

answer: @entity2


abstract: UNASSIGNED: Background and purpose - The discrepancy between symptoms and radiographic severity of @entity3 ( @entity2 ) is well described. However, little is known about whether radiographic severity is predictive of the clinical result of nonoperative treatment. We investigated whether radiographic severity and treatment type were associated with improvements in @entity1 after nonoperative treatment of @entity0 with knee @entity2 . @entity0 and methods - A 5-year consecutive series of @entity0 deemed not eligible for total knee arthroplasty (TKA) by an experienced orthopedic surgeon was contacted 1-5 years later. Radiographic severity, age, sex, and BMI were registered at the consultation. At follow-up, @entity0 were asked to answer a questionnaire on type of treatment and improvements in @entity1 after treatment. Results - Of 1,848 @entity0 who were not eligible for @entity4 ,414 (77%) completed the follow-up questionnaire (mean age 66 (24-96) years; 55% @entity0 ). Radiographic severity was not associated with improvements in @entity1 even after adjusting for treatment type, age, sex, and BMI (p > 0.1). The odds ratio of improvement was higher by a factor of 2 in @entity0 who received physiotherapy or multimodal treatment than in @entity0 who did not. Interpretation - Radiographic severity was not associated with improvements in @entity1 after nonoperative treatment. @entity0 who are not eligible for TKA can confidently be referred to nonoperative treatment even if they have severe radiographic @entity2 . The treatment should preferably be multimodal, including physiotherapy, as recommended in Danish and international clinical guidelines.

title: Nonoperative treatment improves XXXX irrespective of radiographic severity.

answer: @entity1


abstract: OBJECTIVES:     The study was carried out to learn if the columellar-frenulum angle could be used as one of the most important anthropometric measurements to predict the clinical severity in @entity2 @entity0 . SETTINGS AND DESIGN:     This is a prospective case series conducted at Banaras Hindu University, Varanasi, India. METHODS AND MATERIAL:     The study was based on the Thomson and Reinders criteria (1995), and various anthropometric measurements, including the columellar-frenulum angle, were measured. A total of 30 @entity0 (21 @entity0 and 9 @entity0 ) were included in the study. The ages of the @entity0 varied from 4 months to 15 years. The left side was affected in 18 @entity0 , and 2 gave a significant positive family history. All the @entity0 were subjected uniformly to @entity2 repair. @entity0 with strictly @entity2 were included in the study. @entity1 , incomplete @entity2 , and bilateral clefts were excluded from the study. STATISTICAL ANALYSIS:     The data was analyzed using Pearson's correlation coefficient. RESULTS:     The CF angle correlated negatively with the soft tissue defect of the cleft, cutaneous lip length, and vermilion lip length discrepancies from normal and soft tissue width just behind the alveolus. CONCLUSIONS:     CF angle promises to offer a method by which prognosis of clefts can be predicted in terms of its severity in @entity0 with @entity2 .

title: Columellar-Frenulum Angle - A Significant Clinical Parameter in Assessing the Degree of Severity in XXXX .

answer: @entity2


abstract: UNASSIGNED: This study is among the first to examine the @entity1 and attendant factors of young @entity0 who have sex with @entity0 (YMSM) in Hong Kong using location-aware gay social networking mobile applications ("gay apps"). Among the 213 YMSM (Mage   =   21.52, SD   =   2.29 years, range 17-25) who reported their recent (past six months) sexual history with male partners and gay apps use, inconsistent condom use (ICU) during anal sex was fairly common (60.2% regular partners, 45.8% non-regular partners). One-fifth of the sample reported @entity4 ( @entity4 ) during anal sex (19.3% insertive, 19.8% receptive). Frequent "Grindr" and "Jack'd" users were less likely to report anal sex, and hence ICU, with regular [adjusted odds ratio (AOR)   =   0.72] and non-regular (AOR   =   0.62) partners, respectively. Sexual partnering via apps doubled the odds of ICU with both regular (AOR   =   1.99) and non-regular (AOR   =   2.17) partners. The odds of ICU with regular partners also increased with relationship status (AOR   =   2.86 exclusive, AOR   =   3.23 non-exclusive) but reduced for those who never had STI/ @entity3 testing (AOR   =   0.27). With non-regular partners, YMSM's likelihood of ICU increased with more recent partners (AOR   =   3.25) and drug use (AOR   =   3.79), but reduced with group sex (AOR   =   0.15). The odds of receptive @entity4 increased with @entity2 consumption (AOR   =   4.04), non-exclusive relationship (AOR   =   4.10), and more recent partners (AOR   =   2.47), but reduced with group sex (AOR   =   0.15) and older age (AOR   =   0.84). For insertive @entity4 , the odds increased with bisexual YMSM (AOR   =   2.89), exclusive relationship (AOR   =   3.97), and longtime apps-use (AOR   =   1.81). The findings identify meaningful differences among YMSM app-users that inform sexual health intervention and suggest attention on @entity2 or drug use during sex and condomless sex with non-exclusive regular partners.

title: Sexual risk behaviors among apps-using young XXXX who have sex with @entity0 in Hong Kong.

answer: @entity0


abstract: UNASSIGNED: This study is among the first to examine the @entity1 and attendant factors of young @entity0 who have sex with @entity0 (YMSM) in Hong Kong using location-aware gay social networking mobile applications ("gay apps"). Among the 213 YMSM (Mage   =   21.52, SD   =   2.29 years, range 17-25) who reported their recent (past six months) sexual history with male partners and gay apps use, inconsistent condom use (ICU) during anal sex was fairly common (60.2% regular partners, 45.8% non-regular partners). One-fifth of the sample reported @entity4 ( @entity4 ) during anal sex (19.3% insertive, 19.8% receptive). Frequent "Grindr" and "Jack'd" users were less likely to report anal sex, and hence ICU, with regular [adjusted odds ratio (AOR)   =   0.72] and non-regular (AOR   =   0.62) partners, respectively. Sexual partnering via apps doubled the odds of ICU with both regular (AOR   =   1.99) and non-regular (AOR   =   2.17) partners. The odds of ICU with regular partners also increased with relationship status (AOR   =   2.86 exclusive, AOR   =   3.23 non-exclusive) but reduced for those who never had STI/ @entity3 testing (AOR   =   0.27). With non-regular partners, YMSM's likelihood of ICU increased with more recent partners (AOR   =   3.25) and drug use (AOR   =   3.79), but reduced with group sex (AOR   =   0.15). The odds of receptive @entity4 increased with @entity2 consumption (AOR   =   4.04), non-exclusive relationship (AOR   =   4.10), and more recent partners (AOR   =   2.47), but reduced with group sex (AOR   =   0.15) and older age (AOR   =   0.84). For insertive @entity4 , the odds increased with bisexual YMSM (AOR   =   2.89), exclusive relationship (AOR   =   3.97), and longtime apps-use (AOR   =   1.81). The findings identify meaningful differences among YMSM app-users that inform sexual health intervention and suggest attention on @entity2 or drug use during sex and condomless sex with non-exclusive regular partners.

title: Sexual risk behaviors among apps-using young @entity0 who have sex with XXXX in Hong Kong.

answer: @entity0


abstract: BACKGROUND: @entity4 is the fourth most frequent @entity1 and the second cause of @entity1 -related @entity3 worldwide. China has a high incidence of @entity4 . @entity2 is a critical component of @entity1 progression. It has been widely accepted that @entity4 is an inflammation-driven @entity1 . In this study, we investigated the application value of systemic inflammatory response (SIR) markers, platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR), in early diagnosis and prognostic prediction in @entity0 with resectable @entity4 . MATERIALS AND METHODS: One hundred and sixty-two @entity0 with resectable @entity4 were included and separated into groups according to median pre-operative PLR or NLR values (PLR low: < 208 or PLR high: >=  208, and NLR low: < 4.02 or NLR high: >=  4.02, respectively). To evaluate the changes in PLR or NLR values after operation, we introduced the concept of post-/pre-operative PLR or NLR ratios (< 1 indicated PLR or NLR values were decreased after operation, while >=  1 suggested not decreased PLR or NLR values). RESULTS: Pre-operative PLR and NLR levels were significantly higher in @entity4 @entity0 compared with the healthy subjects. Low pre-operative PLR and NLR levels correlated with better clinicopathological features, including decreased depth of invasion, less @entity5 and early @entity1 stage. Kaplan-Meier plots illustrated that higher pre-operative NLR and PLR had decreased overall survival (OS) and disease-free survival (DFS). @entity1 resection resulted in a significant\linebreak.

title: Application of platelet/lymphocyte and neutrophil/lymphocyte ratios in early diagnosis and prognostic prediction in @entity0 with resectable XXXX .

answer: @entity4


abstract: BACKGROUND: @entity4 is the fourth most frequent @entity1 and the second cause of @entity1 -related @entity3 worldwide. China has a high incidence of @entity4 . @entity2 is a critical component of @entity1 progression. It has been widely accepted that @entity4 is an inflammation-driven @entity1 . In this study, we investigated the application value of systemic inflammatory response (SIR) markers, platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR), in early diagnosis and prognostic prediction in @entity0 with resectable @entity4 . MATERIALS AND METHODS: One hundred and sixty-two @entity0 with resectable @entity4 were included and separated into groups according to median pre-operative PLR or NLR values (PLR low: < 208 or PLR high: >=  208, and NLR low: < 4.02 or NLR high: >=  4.02, respectively). To evaluate the changes in PLR or NLR values after operation, we introduced the concept of post-/pre-operative PLR or NLR ratios (< 1 indicated PLR or NLR values were decreased after operation, while >=  1 suggested not decreased PLR or NLR values). RESULTS: Pre-operative PLR and NLR levels were significantly higher in @entity4 @entity0 compared with the healthy subjects. Low pre-operative PLR and NLR levels correlated with better clinicopathological features, including decreased depth of invasion, less @entity5 and early @entity1 stage. Kaplan-Meier plots illustrated that higher pre-operative NLR and PLR had decreased overall survival (OS) and disease-free survival (DFS). @entity1 resection resulted in a significant\linebreak.

title: Application of platelet/lymphocyte and neutrophil/lymphocyte ratios in early diagnosis and prognostic prediction in XXXX with resectable @entity4 .

answer: @entity0


abstract: AIM: Aim of this pilot-study was to quantify perfusion changes of @entity3 before and after the first interventional treatment using contrast-enhanced ultrasound (CEUS). MATERIAL AND METHODS: 29 @entity0 (10 male, 19 female) between 6 and 63 years (mean 25.8 years) with 12 arterio-venous ( @entity4 ) and 17 @entity2 ( @entity2 ) were examined before and after their first percutaneous interventional treatment. CEUS was performed with a 2.4ml bolus injection of @entity1 -hexafluorid microbubbles, and a 6-9MHz mulitfrequency transducer. A 60sec cine sequence was recorded and regions of interest (10mm * 30mm) were defined in the centre, and the margins of the @entity3 as well as in the surrounding healthy tissue. Time Intensity Curves (TIC) were analysed, and Time to Peak (TTP) as well as Area under the Curve (AUC) were calculated. RESULTS: For VMs there was a significant perfusion difference (p< 0.05) in AUC between centre and the surrounding tissue before (332.1 vs. 130.4 rU) and after treatment (331.0 vs. 106.9 rU). There was no significant difference for TTP in ROIs of @entity2 (19.1 vs. 26.5sec). After the treatment there was a significant decrease in AUC for all three regions in AVMs, and an increase in TTP for AVMs. However TTP for AVMs in the centre ROI still remained shorter than in the surrounding tissue even after therapy (20.9 vs. 25.4sec). CONCLUSION: CEUS with TIC analysis is a promising imaging method for the evaluation of perfusion before and after percutaneous treatment of @entity3 . AUC decrease indicates therapy-induced changes in perfusion of @entity2 whereas an increase in TTP shows therapy-related changes in @entity4 .

title: Perfusion quantification of XXXX using contrast-enhanced ultrasound (CEUS) with time intensity curve analysis before and after treatment: First  results.

answer: @entity3


abstract: BACKGROUND: NdgR is an IclR-type transcription factor that regulates @entity0 biosynthesis and other metabolic pathways in @entity7 . Recent study revealed that NdgR is one of the regulatory targets of SigR, an oxidative stress response sigma factor, suggesting that the NdgR plays an important physiological role in response to environmental stresses. Although the regulatory functions of NdgR were partly characterized, determination of its regulon is required for better understanding of the transcriptional regulatory network related with the oxidative stress response. RESULTS: We determined genome-wide binding loci of NdgR by using chromatin immunoprecipitation coupled with sequencing (ChIP-seq) and explored its physiological roles. The ChIP-seq profiles revealed 19 direct binding loci with a 15-bp imperfect palindromic motif, including 34 genes in their transcription units. Most genes in branched-chain @entity5 and @entity1 biosynthesis pathways were involved in the NdgR regulon. We proved that ndgR is induced by SigR under the @entity3 oxidation, and that an ndgR mutant strain is sensitive to the @entity3 oxidizing agent, @entity6 . Through the expression test of NdgR and the target genes for NdgR under @entity6 treatment, regulatory motifs were suggested. Interestingly, NdgR constitutes two regulatory motifs, coherent and incoherent feed-forward loops (FFL), in order to control its regulon under the @entity6 treatment. Using the regulatory motifs, NdgR regulates @entity1 biosynthesis in response to @entity3 oxidative stress, enabling cells to maintain @entity2 assimilation with homeostasis under stress conditions. CONCLUSIONS: Our analysis revealed that NdgR is a global transcriptional regulator involved in the regulation of branched-chain @entity4 biosynthesis and sulphur assimilation. The identification of the NdgR regulon broadens our knowledge regarding complex regulatory networks governing @entity5 biosynthesis in the context of stress responses in @entity7 .

title: Genome-scale analysis reveals a role for NdgR in the XXXX oxidative stress response in @entity7 .

answer: @entity3


abstract: BACKGROUND: NdgR is an IclR-type transcription factor that regulates @entity0 biosynthesis and other metabolic pathways in @entity7 . Recent study revealed that NdgR is one of the regulatory targets of SigR, an oxidative stress response sigma factor, suggesting that the NdgR plays an important physiological role in response to environmental stresses. Although the regulatory functions of NdgR were partly characterized, determination of its regulon is required for better understanding of the transcriptional regulatory network related with the oxidative stress response. RESULTS: We determined genome-wide binding loci of NdgR by using chromatin immunoprecipitation coupled with sequencing (ChIP-seq) and explored its physiological roles. The ChIP-seq profiles revealed 19 direct binding loci with a 15-bp imperfect palindromic motif, including 34 genes in their transcription units. Most genes in branched-chain @entity5 and @entity1 biosynthesis pathways were involved in the NdgR regulon. We proved that ndgR is induced by SigR under the @entity3 oxidation, and that an ndgR mutant strain is sensitive to the @entity3 oxidizing agent, @entity6 . Through the expression test of NdgR and the target genes for NdgR under @entity6 treatment, regulatory motifs were suggested. Interestingly, NdgR constitutes two regulatory motifs, coherent and incoherent feed-forward loops (FFL), in order to control its regulon under the @entity6 treatment. Using the regulatory motifs, NdgR regulates @entity1 biosynthesis in response to @entity3 oxidative stress, enabling cells to maintain @entity2 assimilation with homeostasis under stress conditions. CONCLUSIONS: Our analysis revealed that NdgR is a global transcriptional regulator involved in the regulation of branched-chain @entity4 biosynthesis and sulphur assimilation. The identification of the NdgR regulon broadens our knowledge regarding complex regulatory networks governing @entity5 biosynthesis in the context of stress responses in @entity7 .

title: Genome-scale analysis reveals a role for NdgR in the @entity3 oxidative stress response in XXXX .

answer: @entity7


abstract: OBJECTIVE: We aimed to investigate the prevalence and etiology of @entity3 abnormalities ( @entity5 and @entity6 ) and management approaches for hospitalized @entity0 . SUBJECTS AND METHODS: Over a 4-month period, all hospitalized @entity0 at Hacettepe University Medical Faculty Hospitals who underwent at least one measurement of serum @entity3 during hospitalization were included. Data on serum levels of electrolytes, demographic characteristics, cause(s) of hospitalization, medications, etiology of @entity3 abnormality and treatment approaches were obtained from the hospital records. RESULTS: Of the 9,045 hospitalized @entity0 , 1,265 (14.0%) had a serum @entity3 abnormality; 604 (6.7%) @entity0 had @entity5 and 661 (7.30%) had @entity6 . In the @entity8 @entity0 , the most important reasons were gastrointestinal losses in 555 (91.8%) @entity0 and renal losses in 252 (41.7%) @entity0 . The most frequent treatment strategies were correcting the underlying cause and replacing the @entity3 deficit. Of the 604 @entity8 @entity0 , 319 (52.8%) were normokalemic at hospital discharge. The most common reason for @entity6 was treatment with @entity2 -angiotensin- @entity4 system blockers in 228 (34.4%) @entity0 , followed by @entity1 in 191 (28.8%). Two hundred and ninety-eight (45.0%) @entity0 were followed without any specific treatment. Of the 661 @entity7 @entity0 , 324 (49.0%) were normokalemic at hospital discharge. CONCLUSION: This study showed a high prevalence of @entity3 imbalance among hospitalized @entity0 . Although most of the @entity3 abnormalities were mild/moderate, approximately half of the @entity0 treated for @entity5 or @entity6 were discharged from the hospital with ongoing dyskalemia.    2015 S. Karger AG, Basel.

title: XXXX Abnormalities in Current Clinical Practice: Frequency, Causes, Severity and Management.

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) has recently gained attention as an alternative to parameters used in traditional @entity2 ( @entity2 ). Because @entity4 is paresthesia free, the gate theory of @entity1 control as a basis of @entity2 has been called into question. The mechanism of action of @entity4 remains unclear. OBJECTIVE: We compare the effects of @entity4 and traditional @entity2 on quantitative sensory testing parameters to provide insight into how @entity4 modulates the nervous system. METHODS: Using quantitative sensory testing, we measured thermal detection and @entity1 thresholds and mechanical detection and pressure @entity1 thresholds, as well as vibratory detection, in 20 @entity2 @entity0 off stimulation (OFF), on traditional stimulation (ON) and on @entity4 in a randomized order. RESULTS: @entity4 significantly increased the mechanical detection threshold compared to OFF stimulation (p < 0.001) and traditional @entity2 (p = 0.01). Pressure @entity1 detection and vibratory detection thresholds also significantly increased with @entity4 compared to ON states (p = 0.04 and p = 0.01, respectively). In addition, @entity4 significantly decreased 10- and 40-gram pinprick detection compared to OFF states (both p = 0.01). No significant differences between OFF, ON and @entity4 states were seen in thermal and thermal @entity1 detection. CONCLUSION: @entity4 is a new means of modulating @entity3 . The mechanism by which @entity4 works seems to differ from that of traditional @entity2 , offering a new platform for innovative advancements in treatment and a greater potential to treat @entity0 by customizing waveforms.

title: The Effect of High-Frequency Stimulation on Sensory Thresholds in XXXX @entity0 .

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) has recently gained attention as an alternative to parameters used in traditional @entity2 ( @entity2 ). Because @entity4 is paresthesia free, the gate theory of @entity1 control as a basis of @entity2 has been called into question. The mechanism of action of @entity4 remains unclear. OBJECTIVE: We compare the effects of @entity4 and traditional @entity2 on quantitative sensory testing parameters to provide insight into how @entity4 modulates the nervous system. METHODS: Using quantitative sensory testing, we measured thermal detection and @entity1 thresholds and mechanical detection and pressure @entity1 thresholds, as well as vibratory detection, in 20 @entity2 @entity0 off stimulation (OFF), on traditional stimulation (ON) and on @entity4 in a randomized order. RESULTS: @entity4 significantly increased the mechanical detection threshold compared to OFF stimulation (p < 0.001) and traditional @entity2 (p = 0.01). Pressure @entity1 detection and vibratory detection thresholds also significantly increased with @entity4 compared to ON states (p = 0.04 and p = 0.01, respectively). In addition, @entity4 significantly decreased 10- and 40-gram pinprick detection compared to OFF states (both p = 0.01). No significant differences between OFF, ON and @entity4 states were seen in thermal and thermal @entity1 detection. CONCLUSION: @entity4 is a new means of modulating @entity3 . The mechanism by which @entity4 works seems to differ from that of traditional @entity2 , offering a new platform for innovative advancements in treatment and a greater potential to treat @entity0 by customizing waveforms.

title: The Effect of High-Frequency Stimulation on Sensory Thresholds in @entity3 XXXX .

answer: @entity0


abstract: BACKGROUND: In severe @entity12 , @entity1 are described more rarely than cardiac manifestations. We report a clinical case; present a systematic review of available literature on secondary hyperkalemic @entity7 (SHP); and also discuss pathogenesis, clinical effects, and therapeutic options. CASE REPORT: A 75-year-old @entity0 presented to the emergency department complaining of @entity13 . Her serum @entity9 level was 11.4 mEq/L. Electrocardiogram (ECG) showed a pacemaker (PMK)-induced rhythm, with loss of atrial capture and wide QRS complexes. After emergency treatment to restore cell membrane potential threshold and lower serum @entity9 , neurologic and ECG signs completely disappeared. An acute @entity5 subsequently occurred, possibly linked to @entity6 induced by @entity11 therapy. We reviewed 99 articles (119 patients). Mean serum @entity9 was 8.8 mEq/L. In most cases, ECG showed the presence of tall T waves; loss of PMK atrial capture was documented in 5 @entity0 . In 94 @entity0 , flaccid @entity7 was described and in 25, severe @entity4 ; in 65 @entity0 , these findings were associated with other symptoms. Concurrent @entity2 was often documented. The most frequent treatments were dialysis and infusion of insulin and @entity3 . Eighty-seven percent of @entity0 had complete resolution of symptoms. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Severe @entity12 is always a life-threatening medical emergency, as it can precipitate fatal @entity8 and @entity7 . SHP should be considered in the differential diagnosis of neurologic signs and symptoms of uncertain etiology, especially in a subject with @entity2 or who is taking medications that may worsen renal function. The presence of a PMK does not necessarily impede hyperkalemic @entity10 .

title: Tetraparesis and Failure of Pacemaker Capture Induced by Severe XXXX : Case Report and Systematic Review of Available Literature.

answer: @entity12


abstract: Sixty-two @entity0 with @entity3 and histological evidence of @entity2 were examined to determine whether clinical features, such as course and degree of systemic involvement, could be related to the class of the immunoglobulins in immune complexes (IC) in both the circulation and the vessel wall. Circulating IC were detected with the 125I-C1q-binding assay (C1q-BA), an anti-IgA inhibition binding assay (a-IgA-Inh BA) and the conglutinin-binding assay (Con-BA). Stabilized heat-aggregated IgG, IgA and IgM were used to determine the immunoglobulin class specificity of these assays. With the C1q-BA only aggregated IgG were detected, with the a-IgA-Inh Ba only aggregates containing IgA. With the Con-BA IgG, IgA or IgM in reactive aggregates were identified with class-specific antibodies. For @entity0 with @entity1 all assays were negative. The a-IgA-Inh BA was frequently positive in sera of @entity0 with chronic cutaneous and acute @entity4 ; in the latter group conglutinin-binding IC of the IgG, IgA and IgM class were also detected. Levels in the C1q-BA were high for @entity0 with chronic @entity4 . Comparison of the results of the IC assays with the immunofluorescence studies of the cutaneous vessel walls of the same @entity0 showed agreement between the results of the C1q-BA and deposition of IgG and the results of the a-IgA-Inh BA and IgA deposition. The class of immunoglobulin in conglutinin-binding IC did not correspond as well with the immunoglobulins in vessel walls. This study shows that certain clinical features of @entity3 are related to the composition of the IC in the circulation and in the vessel wall.

title: Circulating and tissue-bound immune complexes in XXXX : relationship between immunoglobulin class and clinical features.

answer: @entity3


abstract: UNASSIGNED: In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight @entity3 ( @entity3 ) @entity0 using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, @entity1 ( @entity1 ), and @entity2 ( @entity2 ) to @entity1 ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127-4138). Significant negative correlations for four subjects were observed between @entity1 and amounts of VOC change. These results suggest that some @entity0 show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. @entity1 values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and @entity1 of each subject showed that the subjective symptoms, VOC exposure, and @entity1 seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.

title: In-situ Real-Time Monitoring of Volatile Organic Compound Exposure and Heart Rate Variability for @entity0 with XXXX .

answer: @entity3


abstract: UNASSIGNED: In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight @entity3 ( @entity3 ) @entity0 using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, @entity1 ( @entity1 ), and @entity2 ( @entity2 ) to @entity1 ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127-4138). Significant negative correlations for four subjects were observed between @entity1 and amounts of VOC change. These results suggest that some @entity0 show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. @entity1 values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and @entity1 of each subject showed that the subjective symptoms, VOC exposure, and @entity1 seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.

title: In-situ Real-Time Monitoring of Volatile Organic Compound Exposure and Heart Rate Variability for XXXX with @entity3 .

answer: @entity0


abstract: BACKGROUND: The gonadotropin-induced resumption of oocyte meiosis in preovulatory follicles is preceded by expression of epidermal growth factor (EGF)-like peptides, @entity10 ( @entity10 ) and epiregulin ( @entity11 ), in mural granulosa and cumulus cells. Both the gonadotropins and the EGF-like peptides possess the capacity to stimulate resumption of oocyte meiosis in vitro via activation of a broad signaling network in cumulus cells. To better understand the rapid genomic actions of gonadotropins (FSH) and EGF-like peptides, we analyzed transcriptomes of cumulus cells at 3  h after their stimulation. METHODS: We hybridized aRNA from cumulus cells to a @entity2 oligonucleotide microarray and compared the transcriptomes of FSH- and @entity10 / @entity11 -stimulated cumulus cells with untreated control cells and vice versa. The identified over- and underexpressed genes were subjected to functional genomic analysis according to their molecular and cellular functions. The expression pattern of 50 selected genes with a known or potential function in ovarian development was verified by real-time qRT-PCR. RESULTS: Both FSH and @entity10 / @entity11 increased the expression of genes associated with regulation of cell proliferation, cell migration, @entity1 and extracellular matrix remodeling. FSH alone induced the expression of genes involved in inflammatory response and in the response to reactive @entity0 species. Moreover, FSH stimulated the expression of genes closely related to some ovulatory events either exclusively or significantly more than @entity10 / @entity11 ( @entity10 , @entity9 , @entity3 , @entity4 , @entity5 , @entity7 , and @entity12 ). In contrast to @entity10 / @entity11 , FSH also increased the expression of genes coding for key transcription factors ( @entity6 , @entity8 , @entity13 , and @entity14 ), which may contribute to the differing expression profiles of FSH- and @entity10 / @entity11 -treated cumulus cells. CONCLUSIONS: The impact of FSH on cumulus cell gene transcription was higher than the impact of EGF-like factors in terms of the number of cell functions affected as well as the number of over- and underexpressed genes. Both FSH and EGF-like factors overexpressed genes involved in the post-ovulatory switch in steroidogenesis and tissue remodelling. However, FSH was remarkably more efficient in the up-regulation of several specific genes essential for ovulation of matured oocytes and also genes that been reported to play an important role in maturation of cumulus-enclosed oocytes in vitro.

title: Gene expression analysis of XXXX cumulus-oocyte complexes stimulated in vitro with follicle stimulating hormone or epidermal growth factor-like peptides.

answer: @entity2


abstract: CONTEXT: @entity1 ( @entity1 ) has been associated with increased @entity4 ( @entity4 ) in many studies. Most studies have been inadequately powered to assess the effect of parathyroidectomy ( @entity5 ) on @entity4 . OBJECTIVE: The objective was to evaluate whether @entity5 has a benefit on @entity4 in @entity0 with @entity1 . DATA SOURCES: Sources included PubMed, Medline, Cochrane Library, clinicaltrials.gov , review articles, and abstracts from meetings. STUDY SELECTION: Eligible studies included prospective studies of @entity5 vs observation or @entity5 alone in @entity0 with @entity1 who had @entity4 measured by echocardiography. DATA EXTRACTION: Two investigators independently identified eligible studies and extracted data. Random-effects models were used to obtain final pooled estimates. DATA SYNTHESIS: Fifteen studies (four randomized controlled trials and 11 observational) of 457 @entity0 undergoing @entity5 were included. @entity5 was associated with a reduction in @entity4 (crude Hedges gu -0.290    0.070, 95% confidence interval [CI] -0.423 to -0.157) of 11.6 g/m(2) (12.5%) on average. Effect size estimates differed by study duration (P < .001), with improvements seen in shorter ( <=6 mo) but not longer studies. There was a trend toward greater improvement in observational studies vs randomized controlled trials (P = .07), and both serum @entity2 and @entity3 were higher in the former. Using random-effects models, the estimated effect size remained significant (Hedges gu -0.250, 95% CI -0.450 to -0.050). Higher preoperative @entity3 but not @entity2 was associated with a greater decline in @entity4 (b = -.039, 95% CI -0.075 to -0.004). CONCLUSION: @entity5 reduced @entity4 in @entity1 , and higher preoperative @entity3 levels were associated with greater improvements. Because the benefit was limited to short-term studies and @entity1 disease severity was not independent of study design, further work is needed to clarify the factors that influence the change in @entity4 and whether the benefit persists beyond 6 months after @entity5 . Although the clinical significance of the @entity4 improvement is unclear, these data indicate that @entity3 may underlie increased @entity4 in @entity1 .

title: Effect of Parathyroidectomy Upon Left Ventricular Mass in XXXX : A Meta-Analysis.

answer: @entity1


abstract: PURPOSE: Insula involvement in @entity5 more likely causes @entity2 and poor clinical outcome than @entity4 . Our objective was to prove the hypothesis that abundant collateral circulation represented by distal hyperintense vessels (HV) on MRI alleviates insula @entity4 and facilitates prognosis. MATERIAL AND METHODS: One hundred and fourteen @entity1 cases with M1 totally occlusion on MR angiography were documented consecutively from 2012 to 2014. The degree of HV was graded as absent, subtle or prominent. Clinical data were recorded retrospectively by reviewing the medical records. The @entity4 volume on diffusion-weighted image, along with National Institutes of Health @entity1 Scale (NIHSS) and modified Rankin Scale (mRS), was used to evaluate the clinical severity and prognosis. RESULTS: The degree of HV was more abundant in insula-uninvolved @entity1 compared with @entity1 involving insula @entity4 (p  = 0.026). Insula-involved @entity1 @entity0 were older (p  = 0.039) with a higher percentage of @entity3 history (p  = 0.042). Univariate analysis revealed that insula @entity4 , age, @entity4 volume and NIHSS predicted unfavorable prognosis of @entity1 , whereas HV had a favorable effect. The protective effect of HV was confirmed by multivariate analysis. CONCLUSION: HV is a protective barrier between insula @entity4 and severity of clinical symptoms among @entity1 @entity0 .

title: XXXX in proximal middle cerebral artery occlusion.

answer: @entity4


abstract: Over 700 cerebral vascular operations have been undertaken on the Surgical Unit of St Bartholomew's Hospital, London, for @entity1 prophylaxis, the majority being carotid endarterectomies. One of the unique features of the latter procedure is the marked @entity7 . The relation of this change to interference with carotid baroreceptor function was studied by per-operative carotid sinus nerve recording. It was possible to relate nerve activity to the postend-arterectomy changes in the mechanical properties of the vessel wall in the region of the carotid sinus. Postoperative @entity7 episodes could be reversed by the injection of local anaesthetic alongside the carotid sinus nerve through a cannula left in situ at operation.The complications of 425 carotid endarterectomies were analysed by computer and specific risk factors were found to be @entity2 , the presence of @entity8 , and the presence of @entity5 . The carotid angiograms of 200 @entity0 were studied with respect to the extent of the disease at the origin of the internal carotid arteries. The operative complication rate was found to be closely related to the severity of this disease, all severe complications occurring in @entity0 with severe @entity6 or @entity4 . This finding has led to the introduction of the term the ;reperfusion syndrome', and the mechanism of the complication is still under study.Seventy-nine extraintracranial revascularising procedures have been undertaken and this operation has been shown to carry a very low morbidity. The postoperative incidence of recurrent transitory ischaemic attacks (TIAs) and @entity1 is low, but the longest follow-up period is still only 4 years. The value of the procedure for TIAs and @entity1 is under study, as is its place in the treatment of @entity0 with @entity3 .

title: Cerebral revascularisation in XXXX prophylaxis.

answer: @entity1


abstract: BACKGROUND: Carotid @entity6 may be related to @entity1 , which may result in @entity3 or physical and mental disabilities in survivors. OBJECTIVES: Our purpose is to study the association of carotid @entity6 (CAC) on dental panoramic radiographs and two risk factors of @entity1 ( @entity1 ) including @entity2 and @entity5 ( @entity5 ). @entity0 AND METHODS: Panoramic images of 200 @entity0 that were all @entity0 above 50 years of age (a population suffering from @entity4 ) were investigated. All panoramic images were provided under similar conditions in terms of the type of panoramic radiograph equipment, type of applied films and the automatic film processor. Then, the @entity0 answered questions about @entity5 history and taking antihypertensive drugs. We also measured the blood pressure of @entity0 in two separate surveys. Data analysis was performed by SPSS statistical program. We used Exact Fisher test and Chi-Square test at a significant level of less than 0.05 to study the effect of these variables on the occurrence of carotid @entity6 . RESULTS: Among 200 studied samples, 22 of the @entity0 (11%) had carotid @entity6 on the dental panoramic radiograph. In total, 52 @entity0 (26%) had @entity2 and four @entity0 (2%) had a history of @entity5 . Eleven individuals among @entity0 suffering from @entity2 (21.2%) and three individuals among @entity0 with a history of @entity5 (75%) demonstrated CAC on dental panoramic images . CONCLUSIONS: The relationship between CAC found on dental panoramic radiographs and two @entity1 risk factors-- @entity2 and @entity5 -- was significant. Therefore, it seems that detection of CAC on panoramic images of dental @entity0 must be considered by dentists.

title: Relationship between carotid @entity6 detected in dental panoramic images and XXXX and @entity5 .

answer: @entity2


abstract: BACKGROUND: Carotid @entity6 may be related to @entity1 , which may result in @entity3 or physical and mental disabilities in survivors. OBJECTIVES: Our purpose is to study the association of carotid @entity6 (CAC) on dental panoramic radiographs and two risk factors of @entity1 ( @entity1 ) including @entity2 and @entity5 ( @entity5 ). @entity0 AND METHODS: Panoramic images of 200 @entity0 that were all @entity0 above 50 years of age (a population suffering from @entity4 ) were investigated. All panoramic images were provided under similar conditions in terms of the type of panoramic radiograph equipment, type of applied films and the automatic film processor. Then, the @entity0 answered questions about @entity5 history and taking antihypertensive drugs. We also measured the blood pressure of @entity0 in two separate surveys. Data analysis was performed by SPSS statistical program. We used Exact Fisher test and Chi-Square test at a significant level of less than 0.05 to study the effect of these variables on the occurrence of carotid @entity6 . RESULTS: Among 200 studied samples, 22 of the @entity0 (11%) had carotid @entity6 on the dental panoramic radiograph. In total, 52 @entity0 (26%) had @entity2 and four @entity0 (2%) had a history of @entity5 . Eleven individuals among @entity0 suffering from @entity2 (21.2%) and three individuals among @entity0 with a history of @entity5 (75%) demonstrated CAC on dental panoramic images . CONCLUSIONS: The relationship between CAC found on dental panoramic radiographs and two @entity1 risk factors-- @entity2 and @entity5 -- was significant. Therefore, it seems that detection of CAC on panoramic images of dental @entity0 must be considered by dentists.

title: Relationship between carotid XXXX detected in dental panoramic images and @entity2 and @entity5 .

answer: @entity6


abstract: BACKGROUND: Carotid @entity6 may be related to @entity1 , which may result in @entity3 or physical and mental disabilities in survivors. OBJECTIVES: Our purpose is to study the association of carotid @entity6 (CAC) on dental panoramic radiographs and two risk factors of @entity1 ( @entity1 ) including @entity2 and @entity5 ( @entity5 ). @entity0 AND METHODS: Panoramic images of 200 @entity0 that were all @entity0 above 50 years of age (a population suffering from @entity4 ) were investigated. All panoramic images were provided under similar conditions in terms of the type of panoramic radiograph equipment, type of applied films and the automatic film processor. Then, the @entity0 answered questions about @entity5 history and taking antihypertensive drugs. We also measured the blood pressure of @entity0 in two separate surveys. Data analysis was performed by SPSS statistical program. We used Exact Fisher test and Chi-Square test at a significant level of less than 0.05 to study the effect of these variables on the occurrence of carotid @entity6 . RESULTS: Among 200 studied samples, 22 of the @entity0 (11%) had carotid @entity6 on the dental panoramic radiograph. In total, 52 @entity0 (26%) had @entity2 and four @entity0 (2%) had a history of @entity5 . Eleven individuals among @entity0 suffering from @entity2 (21.2%) and three individuals among @entity0 with a history of @entity5 (75%) demonstrated CAC on dental panoramic images . CONCLUSIONS: The relationship between CAC found on dental panoramic radiographs and two @entity1 risk factors-- @entity2 and @entity5 -- was significant. Therefore, it seems that detection of CAC on panoramic images of dental @entity0 must be considered by dentists.

title: Relationship between carotid @entity6 detected in dental panoramic images and @entity2 and XXXX .

answer: @entity5


abstract: PURPOSE: To report the outcomes of combined @entity1 surgery with toric intraocular lens (IOL) implantation when performed in conjunction with transconjunctival sutureless pars plana vitrectomy. DESIGN: Retrospective interventional case series. @entity0 : Consecutive series of 55 eyes of 51 @entity0 from April 2007 to December of 2010. METHODS: All eyes underwent combined simultaneous small incision @entity1 surgery, toric IOL implantation, and transconjunctival sutureless vitrectomy surgery. MAIN OUTCOME MEASURES: Postoperative visual acuity, postoperative @entity2 , and rotational stability of the IOL. RESULTS: Preoperative best-corrected visual acuity was 0.32    0.15 logMar (Snellen 20/43) and improved to 0.16    0.10 (Snellen 20/29) postoperatively uncorrected (P < 0.01) and to 0.08    0.11 best-corrected (Snellen 20/24) (P < 0.01). Preoperative @entity2 was 1.75    1.0 diopters (D) (range, 0-4.75 D) and improved to 0.5    0.50 D (range, 0-2.5 D) postoperatively (P < 0.01). Final measured postoperative IOL @entity3 deviation from target @entity3 was 4    6   (range, 0-32). @entity4 was within 5   of target in 47 (85%) eyes, within 10 degrees of target in 51 (93%) eyes, and was within 15   of target in 52 (95%) eyes. CONCLUSION: Toric lens position and @entity3 remained stable after implantation during combined @entity1 surgery and transconjunctival sutureless vitrectomy.

title: Stability of the acrysof toric intraocular lens in combined XXXX surgery and transconjunctival sutureless vitrectomy.

answer: @entity1


abstract: AIMS: Custom-made footwear is used to offload the @entity1 to prevent @entity3 . This prospective study evaluates the offloading effects of modifying custom-made footwear and aims to provide data-driven directions for the provision of effectively offloading footwear in clinical practice. METHODS: Eighty-five @entity0 with @entity4 and a recently healed plantar foot @entity2 , who participated in a clinical trial on footwear effectiveness, had their custom-made footwear evaluated with in-shoe plantar pressure measurements at three-monthly intervals. Footwear was modified when peak pressure was >=   200  kPa. The effect of single and combined footwear modifications on in-shoe peak pressure at these high-pressure target locations was assessed. RESULTS: All footwear modifications significantly reduced peak pressure at the target locations compared with pre-modification levels (range -6.7% to -24.0%, P  <  0.001). The metatarsal heads were most frequently targeted. Repositioning an existing (trans-)metatarsal pad in the shoe insole (-15.9% peak pressure relief), applying local cushioning to the insole (-15.0%) and replacing the insole top cover with Plastazote (-14.2%) were the most effective single modifications. Combining a new Plastazote top cover with a trans-metatarsal bar (-24.0% peak pressure relief) or with local cushioning (-22.0%) were the most effective combined modifications. CONCLUSIONS: In @entity0 with @entity4 and a recently healed plantar foot @entity2 , significant offloading can be achieved at high-risk foot regions by modifying custom-made footwear. These results provide data-driven directions for the design and evaluation of custom-made footwear for high-risk @entity0 with @entity1 , and essentially mean that each shoe prescribed should incorporate those design features that effectively offload the foot.

title: Data-driven directions for effective footwear provision for the high-risk XXXX .

answer: @entity1


abstract: BACKGROUND: Antimicrobial resistance in @entity7 jeopardizes public health and continues to spread out to currently recommended and older antimicrobial agents. Antimicrobial resistance (AMR) surveillance provides essential clues toward the modification of treatment guidelines. The aim of the study was to determine gonococcal AMR profile and trends between 2007 and 2012 and to evaluate any change in AMR profile in comparison with published trends in 2002 to 2006. METHODS: Antimicrobial susceptibility testing of 261 @entity7 isolates from consecutive @entity0 between 2007 and 2012 was determined for @entity1 , @entity2 , @entity3 , @entity9 , extended-spectrum cephalosporins ( @entity4 , @entity8 , @entity10 ) and @entity6 by the disk diffusion technique and the Etest method. P value was determined using    test for comparisons of trends between the 2 periods. RESULTS: In comparison of AMR trends between 2002-2006 and 2007-2012, penicillinase-producing @entity7 , @entity2 -resistant @entity7 , and @entity3 -resistant strains increased significantly from 21.2% to 47.9% (P < 0.0001), 13.6% to 25.3% (P = 0.0002), and 78% to 89.7% (P = 0.0001), respectively. An insignificant increase from 2.4% to 4.2% (P > 0.05) in decreased susceptibility to @entity4 and 0.8% to 1.5% (P > 0.05) for @entity6 resistance was observed. All isolates were susceptible to spectinomycin over both the periods, except for one isolate in 2002. CONCLUSIONS: The study highlights that there is a continuous increase in resistance to previously recommended antibiotics despite their disuse for treatment. The increase in number of strains with decreased susceptibility to extended-spectrum cephalosporins and @entity6 resistance, currently recommended for management of @entity5 , is of serious concern. These trends should be monitored continuously to change antibiotic policy.

title: Trends of Resistance to Antimicrobials Recommended Currently and in the Past for Management of XXXX in the Apex STD Center in India and Comparison of Antimicrobial Resistance Profile Between 2002-2006 and 2007-2012.

answer: @entity5


abstract: Pasture plots in 3 climatic regions were contaminated with worm eggs of Ostertagia ostertagi, @entity2 , Haemonchus spp and Cooperia spp in the autumn, winter and spring. Successive pairs of parasite-free @entity0 were grazed on the plots for 7 to 10 days at 4-week intervals and then killed for worm counts 14 days after their removal from pasture. On the Northern Tablelands of New South Wales, irrespective of the season of pasture contamination, the degree of inhibition of O. ostertagi was low in winter and highest in spring. @entity2 showed similar trends while Cooperia spp showed negligible inhibition. On the North Coast of New South Wales, inhibited larvae accounted for a very small proportion of the O. ostertagi burdens, while in comparison @entity2 showed a much greater degree of inhibition. Larval inhibition of Haemonchus spp occurred in autumn and early winter after which it did not occur. There was negliglible inhibition in Cooperia spp. On the Central Coast of New South Wales, there was little inhibition of O. ostertagi and none in @entity2 . For Haemonchus spp, inhibited larvae were found mainly in autumn and winter. The numbers of inhibited Cooperia larvae were also highest in autumn and winter and were associated with large worm burdens. The marked difference between the tablelands and coastal regions in the seasonal trends of inhibition of O. ostertagi was considered to be due to a difference in strains between the geographical regions. The possible effect of climatic factors on the inhibition-proneness of infective larvae on pasture is discussed for Ostertagia and other @entity1 . The roles of host resistance and density-dependence are also discussed.

title: Seasonal changes in the structure of @entity1 populations of XXXX in New South Wales in relation to inhibited larval development.

answer: @entity0


abstract: Pasture plots in 3 climatic regions were contaminated with worm eggs of Ostertagia ostertagi, @entity2 , Haemonchus spp and Cooperia spp in the autumn, winter and spring. Successive pairs of parasite-free @entity0 were grazed on the plots for 7 to 10 days at 4-week intervals and then killed for worm counts 14 days after their removal from pasture. On the Northern Tablelands of New South Wales, irrespective of the season of pasture contamination, the degree of inhibition of O. ostertagi was low in winter and highest in spring. @entity2 showed similar trends while Cooperia spp showed negligible inhibition. On the North Coast of New South Wales, inhibited larvae accounted for a very small proportion of the O. ostertagi burdens, while in comparison @entity2 showed a much greater degree of inhibition. Larval inhibition of Haemonchus spp occurred in autumn and early winter after which it did not occur. There was negliglible inhibition in Cooperia spp. On the Central Coast of New South Wales, there was little inhibition of O. ostertagi and none in @entity2 . For Haemonchus spp, inhibited larvae were found mainly in autumn and winter. The numbers of inhibited Cooperia larvae were also highest in autumn and winter and were associated with large worm burdens. The marked difference between the tablelands and coastal regions in the seasonal trends of inhibition of O. ostertagi was considered to be due to a difference in strains between the geographical regions. The possible effect of climatic factors on the inhibition-proneness of infective larvae on pasture is discussed for Ostertagia and other @entity1 . The roles of host resistance and density-dependence are also discussed.

title: Seasonal changes in the structure of XXXX populations of @entity0 in New South Wales in relation to inhibited larval development.

answer: @entity1


abstract: BACKGROUND: The surgical management of locally recurrent @entity1 (LRRC) has become widely accepted to afford cure and improve quality of life in this subset of @entity0 . Thus far, traditional surgical and oncological markers have been used to highlight the success of surgical intervention. The use of @entity0 reported outcomes, specifically health-related quality of life (HRQoL) is sparse in these @entity0 . This maybe in part due to the lack of well-designed, validated instruments. AIM: The study identifies HRQoL issues relevant to @entity0 undergoing surgery for LRRC, with an aim to develop a conceptual framework of HRQoL specific to LRRC to enable measurement of @entity0 reported outcomes in this cohort of @entity0 . METHODS: Qualitative focus groups were undertaken at two institutions to identify relevant HRQoL themes. The principles of thematic content analysis were used to analysis data. NViVo10 was used to analyse data. RESULTS: Twenty-one @entity0 participated in six consecutive focus groups. Two patterns of themes emerged related to HRQoL and healthcare services delivery and utilisation. Identified themes related to HRQoL included symptoms, @entity2 , role and social functioning, future perspective. Under healthcare services and delivery and utilisation the subdomain of disease management, treatment expectations and healthcare professionals were identified. CONCLUSION: This is the first qualitative study undertaken exclusively in @entity0 with LRRC to ascertain relevant HRQoL outcomes. The impact of LRRC on @entity0 is wide-ranging and extends beyond traditional HRQoL outcomes. The study operationalises the identified outcomes into a conceptual framework, which will provide the basis for the development of a LRRC specific @entity0 reported outcome measure. This article is protected by copyright. All rights reserved.

title: Development of a conceptual framework of health-related quality of life in locally recurrent XXXX .

answer: @entity1


abstract: Between November 1964 and December 1981, 80 @entity0 who had undergone an open biopsy of a cervical lymph node containing @entity4 were treated with curative intent in the University of Florida Division of Radiation Therapy. Irradiation was the initial step in the definitive treatment of all @entity0 , followed by neck dissection and/or primary resection, as indicated. The @entity0 were divided into two groups. (a) NX (no gross @entity3 ) (25 @entity0 ): According to the referring surgeons' and pathologists' reports, a single, clinically positive lymph node was totally excised in 25 @entity0 . No other clinically positive lymph nodes were appreciated upon referral. No neck dissections were added following irradiation in this group of @entity0 . The absolute 5 year disease-free survival in the NX group was 79%, and the rate of @entity3 control was 96%. (b) Gross @entity3 (55 @entity0 ): Gross residual disease remained in the neck in 55 @entity0 following biopsy. In some @entity0 , only an incisional biopsy of a large mass had been performed; in others, only one of several involved nodes was removed. The absolute 5 year disease-free survival in this group of @entity0 was 31%, and the rate of @entity3 control was 64%. The more consistent addition of a neck dissection in recent years has resulted in improved neck control rates in this group: 13/20 (65%) for N1-N2 disease and 2/7 (29%) for @entity2 following irradiation alone versus 6/7 (86%) for N2 disease and 5/8 (63%) for @entity2 when a neck dissection was added following irradiation. There are some differences in the rates of neck control, control above the clavicles, survival, distant @entity1 , and complications between this series and other reported series in which open neck-node biopsy preceded definitive treatment. Possible reasons for these differences are discussed.

title: The influence of excisional or incisional biopsy of metastatic neck nodes on the management of XXXX .

answer: @entity3


abstract: UNASSIGNED: Recently, @entity1 has increased due to a variety of reasons, including the availability of 'fast food' and high-fat diets. Developing anti- @entity1 functional drugs and foods from natural sources may offer solutions to this global concern. Generally, tuna is a high-protein, low-fat and low-calorie food with various bioactive effects. It may improve memory, reduce @entity2 levels and positively affect the development of brain cells. In this study, we screened the anti- @entity1 potential of peptides derived from tuna protein. We then observed protein bands by the Coomassie blue staining of a @entity7 - @entity6 gel electrophoresis ( @entity3 -PAGE) gel. The protein mixture was concentrated and desalted using in-gel trypsin digestion and a C18  nano column and Poros  R2 reversed-phase preparation, prior to quadrupole time-of-flight mass spectrometry (Q-TOF @entity0 / @entity0 ). We screened the peptides for their ability to affect adipogenesis in 3T3-L1 adipocytes. We also measured @entity5 uptake, @entity4 levels and lipid droplets using @entity10 staining. As a result, we confirmed that one peptide inhibited adipocyte differentiation. We also observed the expression of @entity1 -related genes by western blot analysis and reverse transcription-polymerase chain reaction. The peptide from the tuna extract significantly reduced the expression levels of CCAAT/enhancer-binding protein  a ( @entity9 ) and peroxisome proliferator-activated receptor-y ( @entity8 -y) adipocyte marker genes. Thus, our data suggest that this peptide from boiled tuna extract reduces lipid components and adipogenesis in 3T3-L1 cells, and these characteristics may be of value in the development of anti- @entity1 foods.

title: Peptide derived from desalinated boiled tuna extract inhibits adipogenesis through the downregulation of XXXX and @entity8 -y in 3T3-L1 adipocytes.

answer: @entity9


abstract: UNASSIGNED: Recently, @entity1 has increased due to a variety of reasons, including the availability of 'fast food' and high-fat diets. Developing anti- @entity1 functional drugs and foods from natural sources may offer solutions to this global concern. Generally, tuna is a high-protein, low-fat and low-calorie food with various bioactive effects. It may improve memory, reduce @entity2 levels and positively affect the development of brain cells. In this study, we screened the anti- @entity1 potential of peptides derived from tuna protein. We then observed protein bands by the Coomassie blue staining of a @entity7 - @entity6 gel electrophoresis ( @entity3 -PAGE) gel. The protein mixture was concentrated and desalted using in-gel trypsin digestion and a C18  nano column and Poros  R2 reversed-phase preparation, prior to quadrupole time-of-flight mass spectrometry (Q-TOF @entity0 / @entity0 ). We screened the peptides for their ability to affect adipogenesis in 3T3-L1 adipocytes. We also measured @entity5 uptake, @entity4 levels and lipid droplets using @entity10 staining. As a result, we confirmed that one peptide inhibited adipocyte differentiation. We also observed the expression of @entity1 -related genes by western blot analysis and reverse transcription-polymerase chain reaction. The peptide from the tuna extract significantly reduced the expression levels of CCAAT/enhancer-binding protein  a ( @entity9 ) and peroxisome proliferator-activated receptor-y ( @entity8 -y) adipocyte marker genes. Thus, our data suggest that this peptide from boiled tuna extract reduces lipid components and adipogenesis in 3T3-L1 cells, and these characteristics may be of value in the development of anti- @entity1 foods.

title: Peptide derived from desalinated boiled tuna extract inhibits adipogenesis through the downregulation of @entity9 and XXXX -y in 3T3-L1 adipocytes.

answer: @entity8


abstract: UNASSIGNED: Intraperitoneal solid @entity2 are far less common in @entity0 than in adults, and the histologic spectrum of @entity2 of the peritoneum and its specialized folds in young @entity0 differs from that in older @entity0 . Localized masses may be caused by @entity2 , @entity14 , @entity4 , or other mesenchymal masses. @entity2 is a @entity5 of borderline biologic potential that appears as a solitary circumscribed mass, possibly with central calcification. @entity14 is an @entity8 that appears as a circumscribed, intensely enhancing mass in the mesentery. @entity4 , or @entity6 , is a benign @entity2 of mesenchymal origin associated with @entity9 . @entity4 appears as a mildly enhancing, circumscribed solitary mass without @entity1 . @entity13 may be due to @entity12 ( @entity12 ), @entity10 , or @entity7 . @entity12 is a rare member of the small round blue cell @entity2 family that causes diffuse peritoneal masses without a visible @entity2 . A dominant mass is typically found in the retrovesical space. @entity11 is a @entity2 that manifests with @entity3 because of its short doubling time. The bowel and adjacent mesentery are commonly involved. @entity7 may arise as a @entity2 of the omentum or may spread from a @entity2 in the bladder, prostate, or scrotum. Knowledge of this spectrum of disease allows the radiologist to provide an appropriate differential diagnosis and suggest proper @entity0 management.

title: Solid Tumors of the Peritoneum, Omentum, and Mesentery in XXXX : Radiologic-Pathologic Correlation: From the Radiologic Pathology Archives.

answer: @entity0


abstract: PURPOSE OF REVIEW: @entity1 causes significant morbidity in cirrhotic @entity0 . Diagnosis is challenging because it is based on serum @entity4 , which is used to calculate estimated glomerular filtration rate, which itself is not an ideal measure of renal function in @entity0 with @entity2 . Finding the exact cause of @entity1 in @entity0 with @entity2 remains problematic due to the limitations of the current diagnostic tests. The purpose of this review is to highlight studies used to diagnose @entity1 in @entity0 with @entity1 and review current treatments. RECENT FINDINGS: New diagnostic criteria and classification of @entity1 , especially for @entity3 ( @entity3 ), have been proposed in hopes of optimizing treatment and improving outcomes. New biomarkers that help to differentiate structural from functional @entity3 in cirrhotic @entity0 have been developed, but require further investigation. Vasoconstrictors are the most commonly recommended treatment of @entity5 ( @entity5 ). Given the high mortality in @entity0 with type 1 @entity5 , all @entity0 with @entity5 should be evaluated for liver transplantation. When @entity1 is considered irreversible, combined liver-kidney transplantation is advised. SUMMARY: Development of new biomarkers to differentiate the different types of @entity3 in @entity2 holds promise. Early intervention in cirrhotic @entity0 with @entity1 offers the best hope of improving outcomes.

title: XXXX in @entity2 .

answer: @entity1


abstract: PURPOSE OF REVIEW: @entity1 causes significant morbidity in cirrhotic @entity0 . Diagnosis is challenging because it is based on serum @entity4 , which is used to calculate estimated glomerular filtration rate, which itself is not an ideal measure of renal function in @entity0 with @entity2 . Finding the exact cause of @entity1 in @entity0 with @entity2 remains problematic due to the limitations of the current diagnostic tests. The purpose of this review is to highlight studies used to diagnose @entity1 in @entity0 with @entity1 and review current treatments. RECENT FINDINGS: New diagnostic criteria and classification of @entity1 , especially for @entity3 ( @entity3 ), have been proposed in hopes of optimizing treatment and improving outcomes. New biomarkers that help to differentiate structural from functional @entity3 in cirrhotic @entity0 have been developed, but require further investigation. Vasoconstrictors are the most commonly recommended treatment of @entity5 ( @entity5 ). Given the high mortality in @entity0 with type 1 @entity5 , all @entity0 with @entity5 should be evaluated for liver transplantation. When @entity1 is considered irreversible, combined liver-kidney transplantation is advised. SUMMARY: Development of new biomarkers to differentiate the different types of @entity3 in @entity2 holds promise. Early intervention in cirrhotic @entity0 with @entity1 offers the best hope of improving outcomes.

title: @entity1 in XXXX .

answer: @entity2


abstract: UNASSIGNED: Background and study aims: The role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in the diagnosis and management of @entity4 (PNETs) is unclear. We aimed to compare clinical/endosonographic characteristics of cystic with solid PNETs, determine diagnostic accuracy of preoperative EUS-FNA, and evaluate recurrence rates after resection. @entity0 and methods: All @entity0 with cystic or solid @entity5 confirmed by EUS-FNA between 2000 and 2014 were identified. A matched case-control study compared 50 consecutive @entity0 with cystic PNETs with 50 consecutive @entity0 with solid PNETs, matched by gender and age at diagnosis of index cystic @entity5 . We compared clinical/endosonographic characteristics, assessed diagnostic accuracy of preoperative EUS-FNA for identifying @entity2 , and analyzed @entity2 -free survival of @entity0 with cystic and solid PNETs. Results: @entity4 tended to be larger than solid PNETs (mean 26.8 vs. 20.1mm, P=0.05), more frequently nonfunctional (96% vs. 80%, P=0.03), and less frequently associated with @entity6 (10% vs. 28%, P=0.04). With surgical pathology as reference standard, EUS-FNA accuracies for @entity2 of cystic and solid PNETs were 89.3% and 90%, respectively; cystic PNETs were less associated with metastatic adenopathy (22% vs. 42%, P=0.03) and liver @entity1 (0% vs. 26%, P<0.001). Cystic fluid analysis (n=13), showed benign cystic PNETs had low @entity3 ( @entity3 ), Ki-67 <=2%, and no loss of heterozygosity. @entity0 with cystic and solid PNETs had similar recurrence risk up to 5 years after complete resection. Conclusions: @entity4 have distinct clinical and EUS characteristics, but were associated with less aggressive biological behavior compared with solid PNETs. EUS-FNA is accurate for determining malignant potential on preoperative evaluation. Despite complete resection, recurrence is observed up to 5 years following surgery.

title: XXXX : outcomes of preoperative endosonography-guided fine needle aspiration, and recurrence during long-term follow-up.

answer: @entity4