abstract: In @entity2 , expression of the pyrC gene is regulated primarily by a translational control mechanism based on @entity1 -sensitive selection of transcriptional start sites at the pyrC promoter. When intracellular levels of @entity0 are high, pyrC transcripts are initiated predominantly with @entity0 at a site 7 bases downstream of the Pribnow box. These transcripts form a stable hairpin at their 5' ends that blocks ribosome binding. When the @entity0 level is low and the @entity6 level is high, conditions found in @entity7 -limited cells, transcripts are initiated primarily with @entity6 at a site 9 bases downstream of the Pribnow box. These shorter transcripts are unable to form a hairpin at their 5' ends and are readily translated. In this study, we examined the effects of @entity1 sequence and position on the selection of transcriptional start sites at the pyrC promoter. We characterized promoter mutations that systematically alter the sequence at position 7 or 9 downstream of the Pribnow box or vary the spacing between the Pribnow box and wild-type transcriptional initiation region. The results reveal preferences for particular initiating @entity5 ( @entity3 > or = @entity6 > @entity4 > @entity0 ) and for starting positions downstream of the Pribnow box (7 > 6 and 8 > 9 > 10). The results indicate that optimal @entity1 -sensitive start site switching at the wild-type pyrC promoter is the result of competition between the preferred start site (position 7) that uses the poorest initiating @entity1 ( @entity0 ) and a weak start site (position 9) that uses a good initiating @entity1 ( @entity6 ). The sequence of the pyrC promoter also minimizes the synthesis of untranslatable transcripts and provides for maximum stability of the regulatory transcript hairpin. In addition, the results show that the effects of the mutations on pyrC expression and regulation are consistent with the current model for translational control. Possible effects of preferences for initiating @entity5 and start sites on the expression and regulation of other genes are discussed.

title: Effects of transcriptional start site sequence and position on @entity1 -sensitive selection of alternative start sites at the pyrC promoter in XXXX .

answer: @entity2


abstract: In @entity2 , expression of the pyrC gene is regulated primarily by a translational control mechanism based on @entity1 -sensitive selection of transcriptional start sites at the pyrC promoter. When intracellular levels of @entity0 are high, pyrC transcripts are initiated predominantly with @entity0 at a site 7 bases downstream of the Pribnow box. These transcripts form a stable hairpin at their 5' ends that blocks ribosome binding. When the @entity0 level is low and the @entity6 level is high, conditions found in @entity7 -limited cells, transcripts are initiated primarily with @entity6 at a site 9 bases downstream of the Pribnow box. These shorter transcripts are unable to form a hairpin at their 5' ends and are readily translated. In this study, we examined the effects of @entity1 sequence and position on the selection of transcriptional start sites at the pyrC promoter. We characterized promoter mutations that systematically alter the sequence at position 7 or 9 downstream of the Pribnow box or vary the spacing between the Pribnow box and wild-type transcriptional initiation region. The results reveal preferences for particular initiating @entity5 ( @entity3 > or = @entity6 > @entity4 > @entity0 ) and for starting positions downstream of the Pribnow box (7 > 6 and 8 > 9 > 10). The results indicate that optimal @entity1 -sensitive start site switching at the wild-type pyrC promoter is the result of competition between the preferred start site (position 7) that uses the poorest initiating @entity1 ( @entity0 ) and a weak start site (position 9) that uses a good initiating @entity1 ( @entity6 ). The sequence of the pyrC promoter also minimizes the synthesis of untranslatable transcripts and provides for maximum stability of the regulatory transcript hairpin. In addition, the results show that the effects of the mutations on pyrC expression and regulation are consistent with the current model for translational control. Possible effects of preferences for initiating @entity5 and start sites on the expression and regulation of other genes are discussed.

title: Effects of transcriptional start site sequence and position on XXXX -sensitive selection of alternative start sites at the pyrC promoter in @entity2 .

answer: @entity1


abstract: BACKGROUND: Although leukocyte adhesion and capillary plugging are postulated to play a role in postischemic tissue injury, there is only limited evidence demonstrating the relationship between tissue leukocyte accumulation and cell injury in terms of their temporal sequence and spatial distribution. EXPERIMENTAL DESIGN: This study was designed to study in vivo neutrophil behavior and its correlation with cell @entity1 . The microcirculation of the @entity0 spinotrapezius muscle was observed in vivo using dual-color digital microfluorography to simultaneously visualize leukocyte traffic and cell death (irreversible nuclear damage) on the basis of @entity6 and @entity4 , respectively. A 1-hour period of hemorrhagic @entity3 (40 mm Hg) followed by reperfusion was carried out to induce @entity1 . RESULTS: @entity3 was followed by an increase in leukocyte recruitment in two different ways: capillary obstruction and @entity7 . Upon reperfusion, a majority of the leukocytes were initially dispersed from the muscle capillaries and venules, but then the number of leukocytes plugging capillaries and adherent to venules increased again in a time-dependent manner. The number of leukocytes obstructing capillaries was closely correlated with the @entity3 . The cell injury became detectable initially at the end of the @entity3 period and then increased explosively after reperfusion before a significant leukocyte accumulation. Reperfusion-induced @entity2 was seen predominantly in reperfused capillaries without plugging leukocytes. A majority of the initially damaged nuclei were those of myocytes in the pericapillary space, but no nuclei of capillary endothelium was involved. @entity8 , a novel inhibitor of @entity5 oxidase, significantly attenuated the early increase in @entity1 and subsequent venular leukocyte adhesion after reperfusion. CONCLUSIONS: These results suggest the involvement of an endothelium-dependent mechanism involving @entity5 oxidase in postischemic irreversible @entity2 . It is conceivable that leukocytes adherent to venules as well as those plugging capillaries play only minor roles in the initial mechanism of reperfusion injury.

title: Spatial and temporal correlation between leukocyte behavior and cell injury in postischemic XXXX skeletal muscle microcirculation.

answer: @entity0


abstract: A gel formulation of the antiallergic compound @entity5 ( @entity5 ) (Rhinaaxia (R)) has been evaluated in a multicenter, randomized, double-blind, three-arm, parallel-group comparison with placebo gel (P) and @entity4 (DSCG) in outpatients suffering from @entity2 ( @entity2 ). Nose and eye symptoms were assessed daily by the @entity0 on visual analog scales (VAS), and medical examinations were held after 1 week and at the end of the 4-week treatment. The use of rescue medications (H1-antagonist ( @entity3 ) and soothing eye-drops (Spersallerg) was recorded as a main assessment indicator of efficacy. For the efficacy analysis, only the periods with relevant pollen concentrations (> or = 50 grains/m3) were considered. The study extended over the two pollen seasons 1989 and 1990. Of 230 included @entity0 , 190 were suitable for efficacy analysis (R = 63, P = 64, DSCG = 63). The VAS data did not reveal a difference between the treatment groups for nasal symptoms, whereas the use of @entity3 tablets was significantly lower in the Rhinaaxia group than in either the placebo (P = 0.0001) or DSCG group (P = 0.03). The eye symptoms were significantly less severe in the Rhinaaxia group than in both placebo (P = 0.0001) and DSCG (P < 0.01) groups. In addition, the use of rescue medication was significantly higher in the placebo than in the Rhinaaxia treatment group (P = 0.0001). The incidence of local untoward effects ( @entity1 in the nose) was slightly higher in the Rhinaaxia group, while the overall tolerability assessment was similarly good in all three treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Nasal application of a gel formulation of XXXX ( @entity5 ) compared with placebo and @entity4 in the symptomatic treatment of @entity2 .

answer: @entity5


abstract: A gel formulation of the antiallergic compound @entity5 ( @entity5 ) (Rhinaaxia (R)) has been evaluated in a multicenter, randomized, double-blind, three-arm, parallel-group comparison with placebo gel (P) and @entity4 (DSCG) in outpatients suffering from @entity2 ( @entity2 ). Nose and eye symptoms were assessed daily by the @entity0 on visual analog scales (VAS), and medical examinations were held after 1 week and at the end of the 4-week treatment. The use of rescue medications (H1-antagonist ( @entity3 ) and soothing eye-drops (Spersallerg) was recorded as a main assessment indicator of efficacy. For the efficacy analysis, only the periods with relevant pollen concentrations (> or = 50 grains/m3) were considered. The study extended over the two pollen seasons 1989 and 1990. Of 230 included @entity0 , 190 were suitable for efficacy analysis (R = 63, P = 64, DSCG = 63). The VAS data did not reveal a difference between the treatment groups for nasal symptoms, whereas the use of @entity3 tablets was significantly lower in the Rhinaaxia group than in either the placebo (P = 0.0001) or DSCG group (P = 0.03). The eye symptoms were significantly less severe in the Rhinaaxia group than in both placebo (P = 0.0001) and DSCG (P < 0.01) groups. In addition, the use of rescue medication was significantly higher in the placebo than in the Rhinaaxia treatment group (P = 0.0001). The incidence of local untoward effects ( @entity1 in the nose) was slightly higher in the Rhinaaxia group, while the overall tolerability assessment was similarly good in all three treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Nasal application of a gel formulation of @entity5 ( XXXX ) compared with placebo and @entity4 in the symptomatic treatment of @entity2 .

answer: @entity5


abstract: A gel formulation of the antiallergic compound @entity5 ( @entity5 ) (Rhinaaxia (R)) has been evaluated in a multicenter, randomized, double-blind, three-arm, parallel-group comparison with placebo gel (P) and @entity4 (DSCG) in outpatients suffering from @entity2 ( @entity2 ). Nose and eye symptoms were assessed daily by the @entity0 on visual analog scales (VAS), and medical examinations were held after 1 week and at the end of the 4-week treatment. The use of rescue medications (H1-antagonist ( @entity3 ) and soothing eye-drops (Spersallerg) was recorded as a main assessment indicator of efficacy. For the efficacy analysis, only the periods with relevant pollen concentrations (> or = 50 grains/m3) were considered. The study extended over the two pollen seasons 1989 and 1990. Of 230 included @entity0 , 190 were suitable for efficacy analysis (R = 63, P = 64, DSCG = 63). The VAS data did not reveal a difference between the treatment groups for nasal symptoms, whereas the use of @entity3 tablets was significantly lower in the Rhinaaxia group than in either the placebo (P = 0.0001) or DSCG group (P = 0.03). The eye symptoms were significantly less severe in the Rhinaaxia group than in both placebo (P = 0.0001) and DSCG (P < 0.01) groups. In addition, the use of rescue medication was significantly higher in the placebo than in the Rhinaaxia treatment group (P = 0.0001). The incidence of local untoward effects ( @entity1 in the nose) was slightly higher in the Rhinaaxia group, while the overall tolerability assessment was similarly good in all three treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Nasal application of a gel formulation of @entity5 ( @entity5 ) compared with placebo and @entity4 in the symptomatic treatment of XXXX .

answer: @entity2


abstract: A gel formulation of the antiallergic compound @entity5 ( @entity5 ) (Rhinaaxia (R)) has been evaluated in a multicenter, randomized, double-blind, three-arm, parallel-group comparison with placebo gel (P) and @entity4 (DSCG) in outpatients suffering from @entity2 ( @entity2 ). Nose and eye symptoms were assessed daily by the @entity0 on visual analog scales (VAS), and medical examinations were held after 1 week and at the end of the 4-week treatment. The use of rescue medications (H1-antagonist ( @entity3 ) and soothing eye-drops (Spersallerg) was recorded as a main assessment indicator of efficacy. For the efficacy analysis, only the periods with relevant pollen concentrations (> or = 50 grains/m3) were considered. The study extended over the two pollen seasons 1989 and 1990. Of 230 included @entity0 , 190 were suitable for efficacy analysis (R = 63, P = 64, DSCG = 63). The VAS data did not reveal a difference between the treatment groups for nasal symptoms, whereas the use of @entity3 tablets was significantly lower in the Rhinaaxia group than in either the placebo (P = 0.0001) or DSCG group (P = 0.03). The eye symptoms were significantly less severe in the Rhinaaxia group than in both placebo (P = 0.0001) and DSCG (P < 0.01) groups. In addition, the use of rescue medication was significantly higher in the placebo than in the Rhinaaxia treatment group (P = 0.0001). The incidence of local untoward effects ( @entity1 in the nose) was slightly higher in the Rhinaaxia group, while the overall tolerability assessment was similarly good in all three treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Nasal application of a gel formulation of @entity5 ( @entity5 ) compared with placebo and XXXX in the symptomatic treatment of @entity2 .

answer: @entity4


abstract: OBJECTIVE: The application of opiates after day case surgery in childhood is discussed controversially because of possible complications. Therefore many anaesthetists try to avoid these substances and prefer peripheral analgesics for @entity2 control. METHODS: By distributing a questionnaire concerning the arguments connected with @entity2 to 267 parents (a total of 78.3% of the questionnaires was returned) of @entity0 that had undergone inguinal herniorrhaphy or orchidopexy we hoped to gain insight into the judgement of peripheral analgesics-in this case @entity3 -following inguinal herniorrhaphy or orchidopexy. During standardized anaesthesia the @entity0 received @entity3 suppositories (15-20 mg/kg BW). After release from the hospital on the same day this drug was administered by the parents in case of necessity. RESULTS: Need for analgesics was significantly higher in the group of orchidopexy than in the group of herniorrhaphy (p < .01) and even memory of @entity1 three days after the operation seemed to be higher in this group. The sleep patterns were more influenced by orchidopexy. Surprisingly 75% of the @entity0 following herniorrhaphy received no analgesics at all after release from the hospital (6 hours postoperatively). CONCLUSION: Following herniorrhaphy the @entity2 therapy with @entity3 seems to be sufficient. For the @entity2 treatment after orchidopexy additional measures like local nerve blocks, regional anesthesia or wound infiltrations with local anaesthetics should be considered.

title: [Pain control with XXXX following inguinal herniorrhaphy or orchidopexy in childhood].

answer: @entity3


abstract: BACKGROUND: Previous in vitro and animal studies demonstrated that transcription factors p- @entity5 and @entity4 are required to induce @entity3 secretion by T helper (Th) 9 cells. It is believed that n factor-kappaB (NF-kB) plays a role in eosinophil survival. The importance of these transcription factors in the pathogenesis of @entity1 ( @entity1 ) in @entity0 is poorly understood. We evaluated p- @entity5 and @entity4 expression in peripheral blood Th9 cells and NF-kB expression in eosinophils during late-phase airway inflammation in @entity1 @entity0 . METHODS: Nineteen adults with @entity1 and 14 adult healthy individuals (HI) were examined. Peripheral blood collected 24  h before (baseline) and 24  h after bronchial allergen challenge. CD4(+) cells and eosinophils were isolated by high-density gradient centrifugation and magnetic separation. The percentage of Th9 cells and apoptotic eosinophils was estimated by flow cytometry. p- @entity5 and @entity4 expression was expressed as mean fluorescence intensity (MFI) in Th9 cells. NF-kB levels were expressed as MFI in peripheral blood eosinophils. Serum @entity3 and @entity2 levels were determined by enzyme-linked immunosorbent assay. RESULTS: At baseline, MFI of p- @entity5 and @entity4 in peripheral blood Th9 cells and MFI of NF-kB in eosinophils and, serum @entity2 and @entity3 levels were greater in @entity1 @entity0 (P   <   0.05). Decreased eosinophil apoptosis was seen in the @entity1 group compared with HI (P   <   0.05). MFI of p- @entity5 , @entity4 , and NF-kB and serum levels of @entity2 and @entity3 were increased in the @entity1 group 24  h after challenge compared with baseline (P   <   0.05). In the @entity1 group, a correlation between serum @entity3 and Th9 cells (r   =   0.7, P   =   0.001) and MFI of @entity4 (r   =   0.6, P   =   0.01) 24  h after bronchial allergen challenge was observed. A correlation between Th9 cells and MFI of p- @entity5 (r   =   0.45, P   =   0.03) as well as MFI of @entity4 (r   =   0.5, P   =   0.02) 24  h after challenge was only observed in @entity1 @entity0 . A correlation between the MFI of NF-kB and eosinophil apoptosis was observed in @entity1 @entity0 24  h before (r   =   -0.46, P   =   0.02) and after (r   =   -0.5, P   =   0.02) challenge. DISCUSSIONS: p- @entity5 and @entity4 may be associated with Th9 cells and @entity3 production, whereas NF-kB and @entity2 may be associated with reduced eosinophil apoptosis in allergen-induced late-phase airway inflammation. TRIAL REGISTRATION: ClinicalTrials.gov NCT02214303.

title: p- @entity5 , XXXX , and NF-kB are involved in allergen-induced late-phase airway inflammation in asthma @entity0 .

answer: @entity4


abstract: BACKGROUND: Previous in vitro and animal studies demonstrated that transcription factors p- @entity5 and @entity4 are required to induce @entity3 secretion by T helper (Th) 9 cells. It is believed that n factor-kappaB (NF-kB) plays a role in eosinophil survival. The importance of these transcription factors in the pathogenesis of @entity1 ( @entity1 ) in @entity0 is poorly understood. We evaluated p- @entity5 and @entity4 expression in peripheral blood Th9 cells and NF-kB expression in eosinophils during late-phase airway inflammation in @entity1 @entity0 . METHODS: Nineteen adults with @entity1 and 14 adult healthy individuals (HI) were examined. Peripheral blood collected 24  h before (baseline) and 24  h after bronchial allergen challenge. CD4(+) cells and eosinophils were isolated by high-density gradient centrifugation and magnetic separation. The percentage of Th9 cells and apoptotic eosinophils was estimated by flow cytometry. p- @entity5 and @entity4 expression was expressed as mean fluorescence intensity (MFI) in Th9 cells. NF-kB levels were expressed as MFI in peripheral blood eosinophils. Serum @entity3 and @entity2 levels were determined by enzyme-linked immunosorbent assay. RESULTS: At baseline, MFI of p- @entity5 and @entity4 in peripheral blood Th9 cells and MFI of NF-kB in eosinophils and, serum @entity2 and @entity3 levels were greater in @entity1 @entity0 (P   <   0.05). Decreased eosinophil apoptosis was seen in the @entity1 group compared with HI (P   <   0.05). MFI of p- @entity5 , @entity4 , and NF-kB and serum levels of @entity2 and @entity3 were increased in the @entity1 group 24  h after challenge compared with baseline (P   <   0.05). In the @entity1 group, a correlation between serum @entity3 and Th9 cells (r   =   0.7, P   =   0.001) and MFI of @entity4 (r   =   0.6, P   =   0.01) 24  h after bronchial allergen challenge was observed. A correlation between Th9 cells and MFI of p- @entity5 (r   =   0.45, P   =   0.03) as well as MFI of @entity4 (r   =   0.5, P   =   0.02) 24  h after challenge was only observed in @entity1 @entity0 . A correlation between the MFI of NF-kB and eosinophil apoptosis was observed in @entity1 @entity0 24  h before (r   =   -0.46, P   =   0.02) and after (r   =   -0.5, P   =   0.02) challenge. DISCUSSIONS: p- @entity5 and @entity4 may be associated with Th9 cells and @entity3 production, whereas NF-kB and @entity2 may be associated with reduced eosinophil apoptosis in allergen-induced late-phase airway inflammation. TRIAL REGISTRATION: ClinicalTrials.gov NCT02214303.

title: p- XXXX , @entity4 , and NF-kB are involved in allergen-induced late-phase airway inflammation in asthma @entity0 .

answer: @entity5


abstract: BACKGROUND: Previous in vitro and animal studies demonstrated that transcription factors p- @entity5 and @entity4 are required to induce @entity3 secretion by T helper (Th) 9 cells. It is believed that n factor-kappaB (NF-kB) plays a role in eosinophil survival. The importance of these transcription factors in the pathogenesis of @entity1 ( @entity1 ) in @entity0 is poorly understood. We evaluated p- @entity5 and @entity4 expression in peripheral blood Th9 cells and NF-kB expression in eosinophils during late-phase airway inflammation in @entity1 @entity0 . METHODS: Nineteen adults with @entity1 and 14 adult healthy individuals (HI) were examined. Peripheral blood collected 24  h before (baseline) and 24  h after bronchial allergen challenge. CD4(+) cells and eosinophils were isolated by high-density gradient centrifugation and magnetic separation. The percentage of Th9 cells and apoptotic eosinophils was estimated by flow cytometry. p- @entity5 and @entity4 expression was expressed as mean fluorescence intensity (MFI) in Th9 cells. NF-kB levels were expressed as MFI in peripheral blood eosinophils. Serum @entity3 and @entity2 levels were determined by enzyme-linked immunosorbent assay. RESULTS: At baseline, MFI of p- @entity5 and @entity4 in peripheral blood Th9 cells and MFI of NF-kB in eosinophils and, serum @entity2 and @entity3 levels were greater in @entity1 @entity0 (P   <   0.05). Decreased eosinophil apoptosis was seen in the @entity1 group compared with HI (P   <   0.05). MFI of p- @entity5 , @entity4 , and NF-kB and serum levels of @entity2 and @entity3 were increased in the @entity1 group 24  h after challenge compared with baseline (P   <   0.05). In the @entity1 group, a correlation between serum @entity3 and Th9 cells (r   =   0.7, P   =   0.001) and MFI of @entity4 (r   =   0.6, P   =   0.01) 24  h after bronchial allergen challenge was observed. A correlation between Th9 cells and MFI of p- @entity5 (r   =   0.45, P   =   0.03) as well as MFI of @entity4 (r   =   0.5, P   =   0.02) 24  h after challenge was only observed in @entity1 @entity0 . A correlation between the MFI of NF-kB and eosinophil apoptosis was observed in @entity1 @entity0 24  h before (r   =   -0.46, P   =   0.02) and after (r   =   -0.5, P   =   0.02) challenge. DISCUSSIONS: p- @entity5 and @entity4 may be associated with Th9 cells and @entity3 production, whereas NF-kB and @entity2 may be associated with reduced eosinophil apoptosis in allergen-induced late-phase airway inflammation. TRIAL REGISTRATION: ClinicalTrials.gov NCT02214303.

title: p- @entity5 , @entity4 , and NF-kB are involved in allergen-induced late-phase airway inflammation in asthma XXXX .

answer: @entity0


abstract: OBJECTIVE: To exploit the prevalence of HPV genotypes 52/58 in a Chinese population, we evaluated algorithms that the use the Cervista Assay A9 group for primary @entity1 screening. METHODS: The SHENCCAST II trial database was re-analyzed, focussing on the A9 pool of the Cervista HR-HPV Assay. Results for the detection CIN2+ and CIN3+ were correlated with a genotyping assay ( @entity3 ) and cervical cytology to explore various screening algorithms. RESULTS: This analysis included 8,556 @entity0 with a mean age of 38.9. CIN 2+ rates were 2.7% (233/8556); CIN 3+ rates were 1.7% (141/8556). Overall @entity4 rates were 11.1% (950/8556) for Cervista, in which A5/A6, A7 and A9 groups were 26.5% (227/950), 22.9% (218/950) and 67.8% (644/950), respectively. The HPV A9 group is highly predictive of high-grade @entity2 (CIN2+ OR   =   103.61, CIN3+ OR   =   128.059). Sensitivity and specificity for Cervista A9 group for CIN 2+ was 85.4% and 94.7%, and for CIN 3+ 89.4% and 93.8% respectively. Cervista A9 Assay followed by triage cytology for non-A9 positives has sensitivity and specificity for CIN2+ of 91.5% of 93.5%, and for CIN 3+ 94.3% and 92.6%. CONCLUSION: Using the Cervista A9 as the primary screen instead of the full Cervista assay, the percentage referred to colposcopy would decrease from 11.1% to 8.8% and percentage requiring cytology would decrease from 11.1% to 3.6%. Sensitivity of detecting CIN 2+(91.5%), CIN3+(94.3%) would remain similar to the complete Cervista HR-HPV assay for CIN 2+(93.1%), CIN3+(95.0%).

title: Evaluation of The Cervista HPV A9 group In Screening @entity0 for XXXX .

answer: @entity1


abstract: OBJECTIVE: To exploit the prevalence of HPV genotypes 52/58 in a Chinese population, we evaluated algorithms that the use the Cervista Assay A9 group for primary @entity1 screening. METHODS: The SHENCCAST II trial database was re-analyzed, focussing on the A9 pool of the Cervista HR-HPV Assay. Results for the detection CIN2+ and CIN3+ were correlated with a genotyping assay ( @entity3 ) and cervical cytology to explore various screening algorithms. RESULTS: This analysis included 8,556 @entity0 with a mean age of 38.9. CIN 2+ rates were 2.7% (233/8556); CIN 3+ rates were 1.7% (141/8556). Overall @entity4 rates were 11.1% (950/8556) for Cervista, in which A5/A6, A7 and A9 groups were 26.5% (227/950), 22.9% (218/950) and 67.8% (644/950), respectively. The HPV A9 group is highly predictive of high-grade @entity2 (CIN2+ OR   =   103.61, CIN3+ OR   =   128.059). Sensitivity and specificity for Cervista A9 group for CIN 2+ was 85.4% and 94.7%, and for CIN 3+ 89.4% and 93.8% respectively. Cervista A9 Assay followed by triage cytology for non-A9 positives has sensitivity and specificity for CIN2+ of 91.5% of 93.5%, and for CIN 3+ 94.3% and 92.6%. CONCLUSION: Using the Cervista A9 as the primary screen instead of the full Cervista assay, the percentage referred to colposcopy would decrease from 11.1% to 8.8% and percentage requiring cytology would decrease from 11.1% to 3.6%. Sensitivity of detecting CIN 2+(91.5%), CIN3+(94.3%) would remain similar to the complete Cervista HR-HPV assay for CIN 2+(93.1%), CIN3+(95.0%).

title: Evaluation of The Cervista HPV A9 group In Screening XXXX for @entity1 .

answer: @entity0


abstract: A 32-year-old male, who had had @entity2 for the past 10 years, was admitted to the neurosurgical institute of Tenri Hospital on @entity6 , 1981. Physical examination on admission revealed some @entity3 , neuroasthenic tendency and a purplish nevus in the left foot. Plain x-ray series of the skull showed several nodular calcified lesions in the medial aspect of the left temporal lobe. Electroencephalography showed sporadic negative spikes and irregular slow waves dominant in the left anterior quadrant of the head. CT scan showed a high-density area in the left hippocampal gyrus with slight enhancement by contrast medium. Under stereotactic consideration, a left temporal osteoplastic craniotomy and total removal of the mass were performed on March 20, 1981. The histological examination proved it to be calcified @entity4 or @entity5 after Penfield and Ward (1948). Postoperative course was uneventful; even 4 weeks after surgery, electroencephalogram became normalized, and memory and @entity1 scores became better. At present, in spite of decreased anticonvulsant, the @entity0 has had no more @entity2 since surgery, and has returned to his business without any complaint. The authors have emphasized the necessity of active operation for @entity5 even for the one located in the depth of the dominant cerebral hemisphere. Stereotactic consideration can make the surgical risk minimize. CT scan especially with its contour plot of the images is helpful precisely to locate the lesion. For the nevus in the left foot, the biopsy was refused by the @entity0 , which might have connection with the intracerebral @entity4 .

title: [A case of XXXX (author's transl)].

answer: @entity5


abstract: Here we compared the effectiveness of neutrons (<E> = 5.5 MeV) versus 60Co gamma-rays in producing @entity2 ( @entity2 ) in @entity0 lymphocytes. To obtain dose-response data, blood samples of six donors were irradiated with doses ranging from 0.1 to 5 Gy for gamma-rays and 0.1-3 Gy for neutrons. A linear @entity1 of @entity2 yield with dose was found for fast neutrons while for gamma-rays a nonlinear @entity1 existed. For both radiation qualities no significant interindividual differences were found. Derived relative biological effectiveness values decreased with increasing dose. The @entity2 frequency distributions were overdispersed with respect to the Poisson distribution, with neutrons showing higher dispersion values than with gamma-rays. To compare the repair kinetics of both radiation qualities split-dose experiments were performed. A dose of 4 Gy gamma-rays (3 Gy neutrons) was delivered either as a single exposure or in two equal fractions separated by time intervals ranging from 30 min to 10 h (30 min to 7 h for neutrons). The data showed for gamma-rays a significant decline (30% +/- 10%) in @entity2 yield with interfraction time due to repair of DNA damage. This repair is a continuous process starting almost immediately after the first of the two doses and lasting 3-5 h. For fast neutrons no decline was observed indicating irreparable damage.

title: Micronuclei induced by fast neutrons versus 60Co gamma-rays in XXXX peripheral blood lymphocytes.

answer: @entity0


abstract: Various procedures for the isolation of insulin-like growth factors (IGF's) from @entity0 plasma were evaluated with emphasis upon the yields of each species obtained. The procedures which were evaluated as first steps from plasma and mixed Cohn fractions included acid- @entity2 extraction, @entity3 , ion-exchange chromatography and gel filtration. Certain two-step combinations of these techniques were also evaluated in order to obtain higher fold-purification. Fractions obtained were tested initially using a competitive binding protein assay and then by radioimmunoassay (RIA) for @entity5 . The results indicated that acceptable yields of @entity5 were obtained by initial gel filtration of acidified plasma on Sephadex G-75 at pH 2.5 followed by chromatography on S.P. Sephadex C-25. Isoelectric focusing of the active fraction thereby obtained under these conditions and subsequent R.I.A. indicated total recoveries of @entity5 of about 23 and 96 mU/litre respectively. Peak recoveries of @entity1 were obtained in a fraction of pI 7.6-8.2 and @entity4 between pI 5.9 and 6.9. The order in which the two steps of gel filtration and ion exchange chromatography were carried out appeared to alter the distribution of IGF's obtained. When ion exchange chromatography was used as the first step, most of the activity was obtained in fractions of pI 4.4-5.9 and was not immunoreactive @entity1 or II.

title: The effect of different isolation procedures on the yields of insulin-like growth factors from XXXX plasma.

answer: @entity0


abstract: The role of the hypothalamic paraventricular nucleus (PVN) region in the control of seasonal @entity2 (PRL) responses was investigated in female Siberian hamsters via disruption of PVN afferent connections from the region of the suprachiasmatic nucleus (SCN). Adult female hamsters received sham surgery or horizontal knife cuts placed ventral to the PVN so as to sever dorsally projecting fibers from the SCN and were either immediately transferred to a short-day photoperiod [10 h light:14 h dark (10L:14D); experiment (exp.) 1A] or returned to the long-day photoperiod (16L:8D; exp. 1B and 2). Serial blood samples were analyzed for determination of circulating PRL and follicle-stimulating hormone (FSH; exp. 1A) levels at various time points after surgery. In exp. 1A, sham-operated animals showed a steady decline in circulating levels of both PRL and FSH during exposure to 10L. Animals with knife cuts that passed through the extent of the SCN were prevented from showing declines in PRL and FSH during exposure to 10L. Animals with knife cuts located ventral to or through the PVN but dorsal to the SCN maintained high FSH levels during short-day exposure but showed a decline in PRL. Similarly, animals with knife cuts in exp. 1B and 2 showed a decline in circulating PRL despite continued exposure to a stimulatory photoperiod. In exp. 2, the efficacy of a dopaminergic agonist ( @entity1 ) and an antagonist ( @entity0 ) in altering circulating PRL under the 16L photoperiod was evaluated. @entity1 induced declines in PRL in knife-cut but not sham-operated animals, whereas administration of @entity0 elevated circulating PRL in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX secretion in female Siberian hamsters following hypothalamic deafferentation: role of photoperiod and dopamine.

answer: @entity2


abstract: Effects of @entity7 on @entity6 pyramidal neurons and synaptic transmission were investigated with intracellular recording in fully submerged @entity0 hippocampal slices. Superfusion with 1-4 mM @entity7 reversibly depolarized the membrane by 15.1 +/- 1.4 mV, reduced the amplitude and broadened the duration of action potentials due to a slower rate of repolarization, without significant change in membrane conductance. When membrane potential was returned to control level by the injection of a steady outward current, action potential amplitude recovered but repolarization remained slow. The extent of depolarization was not dependent on the concentration of @entity7 between 1 and 4 mM. @entity7 greatly depressed orthodromic transmission evoked by the stimulation of Schaffer collateral/commissural fibers several minutes after depolarizing the @entity6 neuron. Interruption of transmission began with a decrease in excitatory postsynaptic potential (EPSP) amplitude and eventually EPSPs were almost eliminated. When @entity7 was removed, it took 2-3 min for membrane potential and 10-15 min for transmission to recover. Inward currents induced by bath application of @entity8 acting on @entity1 ( @entity1 ) receptors were also depressed. In contrast, @entity7 enhanced @entity4 ( @entity2 )-induced currents. This @entity3 disappeared in the absence of added @entity5 . A reduction in @entity8 -induced responses provided a possible explanation for the inhibition of excitatory transmission by @entity7 .

title: Effects of ammonium ions on synaptic transmission and on responses to @entity8 and XXXX in hippocampal @entity6 pyramidal neurons in vitro.

answer: @entity4


abstract: Effects of @entity7 on @entity6 pyramidal neurons and synaptic transmission were investigated with intracellular recording in fully submerged @entity0 hippocampal slices. Superfusion with 1-4 mM @entity7 reversibly depolarized the membrane by 15.1 +/- 1.4 mV, reduced the amplitude and broadened the duration of action potentials due to a slower rate of repolarization, without significant change in membrane conductance. When membrane potential was returned to control level by the injection of a steady outward current, action potential amplitude recovered but repolarization remained slow. The extent of depolarization was not dependent on the concentration of @entity7 between 1 and 4 mM. @entity7 greatly depressed orthodromic transmission evoked by the stimulation of Schaffer collateral/commissural fibers several minutes after depolarizing the @entity6 neuron. Interruption of transmission began with a decrease in excitatory postsynaptic potential (EPSP) amplitude and eventually EPSPs were almost eliminated. When @entity7 was removed, it took 2-3 min for membrane potential and 10-15 min for transmission to recover. Inward currents induced by bath application of @entity8 acting on @entity1 ( @entity1 ) receptors were also depressed. In contrast, @entity7 enhanced @entity4 ( @entity2 )-induced currents. This @entity3 disappeared in the absence of added @entity5 . A reduction in @entity8 -induced responses provided a possible explanation for the inhibition of excitatory transmission by @entity7 .

title: Effects of ammonium ions on synaptic transmission and on responses to @entity8 and @entity4 in hippocampal XXXX pyramidal neurons in vitro.

answer: @entity6


abstract: Effects of @entity7 on @entity6 pyramidal neurons and synaptic transmission were investigated with intracellular recording in fully submerged @entity0 hippocampal slices. Superfusion with 1-4 mM @entity7 reversibly depolarized the membrane by 15.1 +/- 1.4 mV, reduced the amplitude and broadened the duration of action potentials due to a slower rate of repolarization, without significant change in membrane conductance. When membrane potential was returned to control level by the injection of a steady outward current, action potential amplitude recovered but repolarization remained slow. The extent of depolarization was not dependent on the concentration of @entity7 between 1 and 4 mM. @entity7 greatly depressed orthodromic transmission evoked by the stimulation of Schaffer collateral/commissural fibers several minutes after depolarizing the @entity6 neuron. Interruption of transmission began with a decrease in excitatory postsynaptic potential (EPSP) amplitude and eventually EPSPs were almost eliminated. When @entity7 was removed, it took 2-3 min for membrane potential and 10-15 min for transmission to recover. Inward currents induced by bath application of @entity8 acting on @entity1 ( @entity1 ) receptors were also depressed. In contrast, @entity7 enhanced @entity4 ( @entity2 )-induced currents. This @entity3 disappeared in the absence of added @entity5 . A reduction in @entity8 -induced responses provided a possible explanation for the inhibition of excitatory transmission by @entity7 .

title: Effects of ammonium ions on synaptic transmission and on responses to XXXX and @entity4 in hippocampal @entity6 pyramidal neurons in vitro.

answer: @entity8


abstract: UNASSIGNED: We investigated how apes allocated their choices between 2 food options that varied in terms of their quantity and quality. Experiment 1 tested whether subjects preferred an AB option over an A option, where the A item is preferred to the B item (e.g., apple + @entity2 vs. apple). Additionally, we tested whether the length of the intertrial interval (ITI) affected subjects' choices. Five @entity3 , 4 @entity4 , 7 @entity1 , and 10 @entity0 received 3 types of trials: preference (A vs. B), quantity (AA vs. A), and mixed (AB vs. A where A is the preferred food). We used 3 food items that substantially differed in terms of preference ( @entity2 , apples, and pellets). Subjects showed no overall preference for the mixed option (AB) compared with the single option (A), even though they showed clear preferences during both the preference and quantity trials. The intertrial length had no effect on choice behavior. Experiment 2 further explored apes' choices by using 3 highly preferred food items (bananas, grapes, and pellets) in 6 @entity3 , 4 @entity4 , 8 @entity1 , and 18 @entity0 . Unlike the results of Experiment 1, apes generally chose the mixed option. Our results indicated that apes did not show a general "selective-value" effect but chose depending on the relative value of the food items involved. Subjects were more likely to select the mixed over the single option when (a) the mixed option was composed of items that were closer in value and (b) they were compared against the less valuable item forming the mixed option. (PsycINFO Database Record

title: Differences in Between-Reinforcer Value Modulate the Selective-Value Effect in Great Apes (Pan Troglodyes, XXXX , @entity4 , Pongo Abelii).

answer: @entity1


abstract: UNASSIGNED: We investigated how apes allocated their choices between 2 food options that varied in terms of their quantity and quality. Experiment 1 tested whether subjects preferred an AB option over an A option, where the A item is preferred to the B item (e.g., apple + @entity2 vs. apple). Additionally, we tested whether the length of the intertrial interval (ITI) affected subjects' choices. Five @entity3 , 4 @entity4 , 7 @entity1 , and 10 @entity0 received 3 types of trials: preference (A vs. B), quantity (AA vs. A), and mixed (AB vs. A where A is the preferred food). We used 3 food items that substantially differed in terms of preference ( @entity2 , apples, and pellets). Subjects showed no overall preference for the mixed option (AB) compared with the single option (A), even though they showed clear preferences during both the preference and quantity trials. The intertrial length had no effect on choice behavior. Experiment 2 further explored apes' choices by using 3 highly preferred food items (bananas, grapes, and pellets) in 6 @entity3 , 4 @entity4 , 8 @entity1 , and 18 @entity0 . Unlike the results of Experiment 1, apes generally chose the mixed option. Our results indicated that apes did not show a general "selective-value" effect but chose depending on the relative value of the food items involved. Subjects were more likely to select the mixed over the single option when (a) the mixed option was composed of items that were closer in value and (b) they were compared against the less valuable item forming the mixed option. (PsycINFO Database Record

title: Differences in Between-Reinforcer Value Modulate the Selective-Value Effect in Great Apes (Pan Troglodyes, @entity1 , XXXX , Pongo Abelii).

answer: @entity4


abstract: @entity1 has detrimental effects on broad areas of functioning. However, its association with career decision-making factors has been largely unexplored. In the present study, we focused on the association between career decision-making difficulties, career-decision status, and career-preference crystallization, on the one hand, and @entity1 , on the other. The hypothesis that high levels of career decision-making difficulties, less advanced decision status, and low levels of preference crystallization are associated with higher levels of @entity1 was tested with a sample of 222 college seniors. In addition, since it has been found that work-related stressors are more often associated with @entity1 among @entity0 than @entity0 , it was hypothesized that the associations between vocational factors and @entity1 would be stronger for @entity0 than for @entity0 . The @entity0 filled out online self-report questionnaires assessing @entity1 , emotional and personality-related career decision-making difficulties, career-decision status, and career preferences. The results indicated that self-concept and identity-related career decision-making difficulties were associated with @entity1 for both @entity0 and @entity0 . In addition, for @entity0 , but not for @entity0 , less crystallization of career preferences also predicted higher levels of @entity1 . These results show how important it is for counseling psychologists to understand the role of the individual's vocational situation in @entity1 . (PsycINFO Database Record

title: Gender differences in the association of XXXX with career indecisiveness, career-decision status, and career-preference crystallization.

answer: @entity1


abstract: PURPOSE: @entity2 ( @entity2 ) is a rare, albeit aggressive subset of @entity4 , resulting in varied treatment approaches. Given the paucity of data defining the optimal management for early-stage @entity2 , we conducted an analysis using the National Cancer Data Base (NCDB) to identify practice patterns and outcomes. METHODS AND MATERIALS: The NCDB was queried for @entity0 with stage I to II @entity2 diagnosed from 1998 to 2012 receiving @entity5 ( @entity5 ) or @entity3 ( @entity3 ), or both ( @entity5 + @entity3 ). Univariate and multivariable analyses for factors associated with treatment selection were completed using logistic regression. Propensity scores with inverse probability treatment weighting (IPTW) were calculated based on the conditional probability of receiving @entity5 + @entity3 . The log-rank test and Cox proportional hazards modeling with IPTW adjustment were conducted for the survival analyses. RESULTS: In total, 2539 @entity0 were identified. The key characteristics were as follows: 69% were male, 71% were aged >= 60  years, 28% had extranodal involvement, and 51% had stage I disease. Of the 2539 @entity0 , 70% underwent @entity5 , 11% underwent @entity3 , and 19% underwent @entity5 + @entity3 . The use of @entity5 + @entity3 decreased from 23.1% to 14.1% in 1998 to 2002 and 2010 to 2012 (P<.001). @entity5 + @entity3 usage was lower for @entity0 with the following characteristics: age >= 60  years, female sex, @entity1 , and the presence of B symptoms. With a median follow-up period of 42.8  months, the unadjusted 3-year overall survival estimates for @entity0 receiving @entity5 , @entity3 , or @entity5 + @entity3 were 67.8%, 72.4%, and 79.8%, respectively (P<.001). After correcting for indication bias through IPTW-adjusted modeling, @entity5 + @entity3 reduced the risk of overall mortality compared with monotherapy (hazard ratio 0.65, P=.029). CONCLUSIONS: Although uncommon, @entity0 with stage I-II @entity2 can have favorable outcomes. Despite a continued decline in the usage of consolidative @entity3 , combined modality therapy improves survival in this cohort compared with monotherapy.

title: Management Trends and Outcomes for Stage I to II XXXX Using the National Cancer Data Base: Ascertaining the Ideal Treatment Paradigm.

answer: @entity2


abstract: Fifteen @entity0 (nine male, six female) with @entity8 ( @entity8 ) undergoing HLA-identical allogeneic bone marrow transplantation (BMT) received preparative regimens consisting of @entity5 and total lymphoid irradiation. @entity0 were aged from eight to 26 years (median 15 years). Prophylaxis of @entity7 ( @entity7 ) including @entity2 and short course @entity6 was administered. One @entity1 occurred at day 8 post BMT. Among the other 14 @entity0 , one died of @entity4 at day 53 with no evidence of engraftment, 13 were engrafted despite the number of donors exposed in transfusions of previous blood components. Eleven @entity0 have survived from six to 100 months (median, 54 months), post BMT. The remaining two @entity0 died of @entity7 on days 44 and 63. Acute @entity7 occurred among eight of 13 engrafted @entity0 , five of whom were grades II-IV clinically. @entity7 developed among five @entity0 , three of whom were clinically progressive and extensive. Two of three @entity0 with extensive @entity7 had received transfusion of donor's buffy coat after BMT. Our data indicate an engraftment rate of 87% (13/15). The projected probability of disease-free survival was 73% (11/15) at 9.3 years after BMT according to the Kaplan-Meier model. Further efforts must be made to eliminate @entity7 and to control fatal @entity3 .

title: Bone marrow transplantation for XXXX .

answer: @entity8


abstract: Two types of natriuretic peptide receptors ( @entity5 and @entity6 ) are membrane guanylate cyclases whose relative expression varies in different tissues. Because natriuretic peptides have been shown to inhibit aortic smooth muscle proliferation, we investigated the regulation of @entity5 and @entity6 in these cells under different proliferative conditions. NPR subtype mRNA levels were measured by our newly developed quantitative reverse transcription-polymerase chain reaction assay using mutated @entity5 and @entity6 cRNA as internal standards. The functional impact of their expression was determined by @entity4 (ANP)- and C-type natriuretic peptide (CNP)-induced stimulation of @entity3 production. In the intact aorta, @entity6 mRNA levels were found to be 10-fold higher than those of @entity5 . This dominance was further amplified (1000-fold) in long-term cultures (10 to 15 passages) of aortic smooth muscle cells (ASMC). Higher @entity3 production with CNP than with ANP was observed in cultured ASMC from @entity0 -Kyoto (WKY) @entity0 . Similar stimulation by the two agonists was noted in spontaneously @entity1 @entity0 (SHR) cells, paralleled by a 10-fold increase in @entity5 mRNA levels and ANP stimulation of @entity3 in @entity1 cells. The present study also evaluated @entity5 and @entity6 mRNA control by @entity2 ( @entity2 ), an important regulator of cell proliferation that is overexpressed in SHR ASMC. @entity2 decreased both @entity5 and @entity6 mRNA levels with a predominant effect in SHR cells at high cell density.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Regulation of natriuretic peptide receptor A and B expression by XXXX in cultured aortic smooth muscle cells.

answer: @entity2


abstract: For treatment of @entity3 , @entity9 ( @entity8 ) has been the only drug available in Japan. However, IUdR is not completely satisfactory, and alternative antivirals are required. The Association for Research in Infectious @entity6 , Japan, carried out a clinical trial in 92 cases of @entity7 using 3 percent @entity2 ophthalmic ointment to determine its efficacy and safety. In 63 eyes, it had an excellent effect and @entity5 healed within seven days. In 26 eyes, it had a good effect and @entity5 healed within 14 days or became half-size within seven days. Therefore, the response to @entity2 in 96.8 percent of cases was excellent or good. The average healing time in 81 eyes in which @entity5 disappeared within 14 days was 5.8 +/- 3.4 days. Including the five eyes in which @entity5 took more than 14 days to heal, the average healing time of @entity5 was 6.6 +/- 4.8 days. Of the 92 @entity0 treated with @entity2 ointment, one had contact blepharoconjunctivitis and another complained of mild @entity1 . Mild @entity4 , as another side effect of @entity2 ointment, was observed in 22 eyes (23.9 percent) by photo-slit lamp examination, but in these @entity0 it was possible to continue treatment without complaint.

title: Clinical evaluation of @entity2 in the treatment of XXXX .

answer: @entity7


abstract: For treatment of @entity3 , @entity9 ( @entity8 ) has been the only drug available in Japan. However, IUdR is not completely satisfactory, and alternative antivirals are required. The Association for Research in Infectious @entity6 , Japan, carried out a clinical trial in 92 cases of @entity7 using 3 percent @entity2 ophthalmic ointment to determine its efficacy and safety. In 63 eyes, it had an excellent effect and @entity5 healed within seven days. In 26 eyes, it had a good effect and @entity5 healed within 14 days or became half-size within seven days. Therefore, the response to @entity2 in 96.8 percent of cases was excellent or good. The average healing time in 81 eyes in which @entity5 disappeared within 14 days was 5.8 +/- 3.4 days. Including the five eyes in which @entity5 took more than 14 days to heal, the average healing time of @entity5 was 6.6 +/- 4.8 days. Of the 92 @entity0 treated with @entity2 ointment, one had contact blepharoconjunctivitis and another complained of mild @entity1 . Mild @entity4 , as another side effect of @entity2 ointment, was observed in 22 eyes (23.9 percent) by photo-slit lamp examination, but in these @entity0 it was possible to continue treatment without complaint.

title: Clinical evaluation of XXXX in the treatment of @entity7 .

answer: @entity2


abstract: BACKGROUND: The influence of @entity7 on prognosis of @entity0 is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in @entity1 receiving or not receiving adjuvant therapy. METHODS: The immunostaining for @entity7 oncoprotein was performed on @entity4 -solution-fixed, @entity5 -embedded sections of 888 node-positive @entity0 resected between 1980 and 1986 and for which a follow-up of 2.5-10.5 years was available. The staining was performed using a polyclonal antibody (dilution, 1/15). RESULTS: One hundred forty-three cases (16.1%) revealed a positive membrane staining with or without additional cytoplasmic contribution, whereas cytoplasmic staining alone was noted in 118 cases (13.3%). Positive membrane staining was correlated with more involved lymph nodes (P = 0.005), @entity8 (P = 0.002), poor nuclear (P < 0.0001) and histologic (P = 0.007) grades, absence of @entity3 (P < 0.0001) and @entity6 (P < 0.0001) receptor content, and @entity10 expression (P = 0.009). No relation was found (P > 0.05) with either age, @entity2 size, or @entity9 expression. Membrane staining was strongly associated with poor distant metastasis-free or overall survival rate (P < 0.0001), whereas cytoplasmic staining had no prognostic significance. Two hundred thirty-two @entity1 (26.1%) received no additional treatment after surgery. The difference in survival rates between cases with positive and negative staining was only significant among @entity1 submitted to adjuvant chemotherapy or hormone therapy. CONCLUSIONS: This study strongly supports the association of @entity7 oncoprotein expression with poor prognosis in @entity0 and demonstrates that membranous but not cytoplasmic staining is prognostically relevant. It also shows that @entity7 oncoprotein expression is useful in predicting survival time only in @entity1 receiving adjuvant therapy, thus suggesting that it may be a marker of drug resistance.

title: Prognostic significance of XXXX oncoprotein expression in @entity0 . The influence of the pattern of immunostaining and adjuvant therapy.

answer: @entity7


abstract: BACKGROUND: The influence of @entity7 on prognosis of @entity0 is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in @entity1 receiving or not receiving adjuvant therapy. METHODS: The immunostaining for @entity7 oncoprotein was performed on @entity4 -solution-fixed, @entity5 -embedded sections of 888 node-positive @entity0 resected between 1980 and 1986 and for which a follow-up of 2.5-10.5 years was available. The staining was performed using a polyclonal antibody (dilution, 1/15). RESULTS: One hundred forty-three cases (16.1%) revealed a positive membrane staining with or without additional cytoplasmic contribution, whereas cytoplasmic staining alone was noted in 118 cases (13.3%). Positive membrane staining was correlated with more involved lymph nodes (P = 0.005), @entity8 (P = 0.002), poor nuclear (P < 0.0001) and histologic (P = 0.007) grades, absence of @entity3 (P < 0.0001) and @entity6 (P < 0.0001) receptor content, and @entity10 expression (P = 0.009). No relation was found (P > 0.05) with either age, @entity2 size, or @entity9 expression. Membrane staining was strongly associated with poor distant metastasis-free or overall survival rate (P < 0.0001), whereas cytoplasmic staining had no prognostic significance. Two hundred thirty-two @entity1 (26.1%) received no additional treatment after surgery. The difference in survival rates between cases with positive and negative staining was only significant among @entity1 submitted to adjuvant chemotherapy or hormone therapy. CONCLUSIONS: This study strongly supports the association of @entity7 oncoprotein expression with poor prognosis in @entity0 and demonstrates that membranous but not cytoplasmic staining is prognostically relevant. It also shows that @entity7 oncoprotein expression is useful in predicting survival time only in @entity1 receiving adjuvant therapy, thus suggesting that it may be a marker of drug resistance.

title: Prognostic significance of @entity7 oncoprotein expression in XXXX . The influence of the pattern of immunostaining and adjuvant therapy.

answer: @entity0


abstract: @entity3 oncogene amplification and overexpression of @entity0 tissue has been correlated with poor prognosis in @entity1 with both node-positive and node-negative disease. However, several studies have not confirmed this association. Review of these studies reveals the presence of considerable methodological variability including differences in study size, follow-up time, techniques and reagents. The majority of papers with clinical follow-up information are immunohistochemical studies using archival, paraffin-embedded @entity0 , and a variety of @entity3 antibodies have been used in these studies. Very little information, however, is available about the ability of the antibodies to detect overexpression following tissue processing for paraffin-embedding. Therefore, a series of antibodies, reported in the literature or commercially available, were evaluated to assess their sensitivity and specificity as immunohistochemical reagents. @entity2 -embedded samples of 187 @entity0 , previously characterized as frozen specimens for @entity3 /neu amplification by Southern blot and for overexpression by Northern blot, Western blot, and immunohistochemistry, were used. Two multitumor paraffin-embedded tissue blocks were prepared from the previously analyzed @entity0 as a panel of cases to test a series of previously studied and/or commercially available anti- @entity3 antibodies. Immunohistochemical staining results obtained with 7 polyclonal and 21 monoclonal antibodies in sections from paraffin-embedded blocks of these @entity0 were compared. The ability of these antibodies to detect overexpression was extremely variable, providing an important explantation for the variable overexpression rate reported in the literature.

title: Sensitivity of XXXX antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

answer: @entity3


abstract: The intercellular adhesion of circulating leukocytes to vascular endothelium is a prerequisite for leukocyte emigration from the blood to extravascular tissues. This process is facilitated by adhesion molecules on the surfaces of both the vascular endothelial cells and the leukocytes. The experiments presented here demonstrate for the first time that the leukocyte adhesion receptor, @entity6 , is constitutively expressed on cultured cerebromicrovascular endothelial cell lines derived from both spontaneously @entity4 (SHR) @entity1 and normotensive @entity1 -Kyoto (WKY) @entity1 . Both cultures contained similar numbers of cells constitutively expressing this adhesion molecule (31.4% and 29.6%, respectively). Adhesion molecule expression was up-regulated by interleukin-1 beta, @entity0 @entity2 factor-alpha, @entity7 and lipopolysaccharide in a dose- and time-dependent manner. Both cultures exhibited similar maximum levels of adhesion molecule up-regulation to optimal concentrations of all three cytokines. However, SHR endothelial cells were more sensitive to all three cytokines; significantly higher levels of @entity6 expression were seen on SHR as opposed to WKY endothelial cells cultured with sub-optimal cytokine concentrations. It was also observed that lipopolysaccharide up-regulated @entity6 expression on SHR endothelial cells to a greater extent than on WKY endothelial cells. The findings that @entity6 can be up-regulated to a greater degree on SHR endothelial cells may have important implications for in vivo perivascular leukocyte accumulation under @entity4 conditions. These observations indicate a possible mechanism by which @entity4 may predispose to the development of disorders such as @entity5 and @entity3 .

title: Adhesion molecules on normotensive and XXXX @entity1 brain endothelial cells.

answer: @entity4


abstract: The intercellular adhesion of circulating leukocytes to vascular endothelium is a prerequisite for leukocyte emigration from the blood to extravascular tissues. This process is facilitated by adhesion molecules on the surfaces of both the vascular endothelial cells and the leukocytes. The experiments presented here demonstrate for the first time that the leukocyte adhesion receptor, @entity6 , is constitutively expressed on cultured cerebromicrovascular endothelial cell lines derived from both spontaneously @entity4 (SHR) @entity1 and normotensive @entity1 -Kyoto (WKY) @entity1 . Both cultures contained similar numbers of cells constitutively expressing this adhesion molecule (31.4% and 29.6%, respectively). Adhesion molecule expression was up-regulated by interleukin-1 beta, @entity0 @entity2 factor-alpha, @entity7 and lipopolysaccharide in a dose- and time-dependent manner. Both cultures exhibited similar maximum levels of adhesion molecule up-regulation to optimal concentrations of all three cytokines. However, SHR endothelial cells were more sensitive to all three cytokines; significantly higher levels of @entity6 expression were seen on SHR as opposed to WKY endothelial cells cultured with sub-optimal cytokine concentrations. It was also observed that lipopolysaccharide up-regulated @entity6 expression on SHR endothelial cells to a greater extent than on WKY endothelial cells. The findings that @entity6 can be up-regulated to a greater degree on SHR endothelial cells may have important implications for in vivo perivascular leukocyte accumulation under @entity4 conditions. These observations indicate a possible mechanism by which @entity4 may predispose to the development of disorders such as @entity5 and @entity3 .

title: Adhesion molecules on normotensive and @entity4 XXXX brain endothelial cells.

answer: @entity1


abstract: 1 The anti- @entity2 effects and safety of @entity3 have been evaluated in multicentre clinical trials in Japan based on unified study protocols. The results of three studies are reported. 2 A total of 178 @entity0 with essential @entity2 were treated with @entity3 for 12 weeks, 127 of them with @entity3 alone (monotherapy) and the other 51 with @entity3 plus diuretics (combined therapy). 3 Satisfactory antihypertensive effects were achieved in 76 of the 119 assessable @entity0 in the monotherapy group and 25 of the 49 in the combined therapy group. The mean daily doses of @entity3 were 329 mg in the monotherapy group and 374 mg in the combined therapy group. Seven @entity0 (six in the monotherapy group; one in the combined therapy group) were withdrawn from the trials due to side-effects. 4 Sixty-one @entity0 with @entity2 were treated with @entity3 alone or combined with diuretics for 6 months or longer. In most of these @entity0 , good blood pressure control was achieved. No @entity0 had to discontinue the treatment due to side-effects. The mean daily doses of @entity3 were stabilised in and after week 8 of the treatment at an average of 260 mg in the monotherapy and 450 mg in the combined therapy. Tolerance to the anti- @entity2 effect did not develop. 5 Thirty @entity0 with phaeochromocytoma were treated with @entity3 and good blood pressure control was achieved in 21 of them. The effects of @entity3 were better in @entity0 with predominantly adrenaline-secreting @entity1 , and better in @entity0 with sustained @entity2 type than in those with paroxysmal @entity2 type.

title: The use of XXXX in Japan: results of multicentre clinical trials.

answer: @entity3


abstract: Various studies have demonstrated the usefulness of monoclonal antibodies in recognizing discrete @entity2 antigenic determinants. The present study describes the tissue reactivity of monoclonal antibodies prepared against a @entity5 . Antigens were purified from the @entity2 extract by anti- @entity7 affinity chromatography. These @entity8 -associated antigens demonstrated @entity2 specificity by the leukocyte adherence inhibition assay. Antibody-secreting hybridomas were generated by fusion of @entity3 @entity6 cells with @entity3 spleen cells immunized with purified @entity2 antigens. Hybridomas were selected by a solid-phase @entity2 membrane-binding immunoassay. The target specificity of the secreted monoclonal antibodies was ascertained by radioimmunoprecipitation analysis and indirect immunofluorescence on various @entity0 @entity2 and normal tissue sections. Monoclonal antibody-secreting hybridomas 48.4.8 and 48.4.2 secreted immunoglobulin that selectively immunoprecipitated polypeptide fragments from @entity0 @entity1 membrane antigens. Hybridoma 9.2.2 secreted antibody that was strongly positive by indirect immunofluorescence on all tested lung @entity5 . Adjacent or intervening normal lung tissue did not display significant immunofluorescence. @entity4 of the lung were negative or focally positive when focal squamous cell differentiation was present. @entity9 were negative. The secreted antibody did not significantly stain three extrapulmonary @entity2 or a variety of normal tissues.

title: Monoclonal antibodies to @entity0 XXXX antigens demonstrated by immunofluorescence and immunoprecipitation.

answer: @entity1


abstract: Various studies have demonstrated the usefulness of monoclonal antibodies in recognizing discrete @entity2 antigenic determinants. The present study describes the tissue reactivity of monoclonal antibodies prepared against a @entity5 . Antigens were purified from the @entity2 extract by anti- @entity7 affinity chromatography. These @entity8 -associated antigens demonstrated @entity2 specificity by the leukocyte adherence inhibition assay. Antibody-secreting hybridomas were generated by fusion of @entity3 @entity6 cells with @entity3 spleen cells immunized with purified @entity2 antigens. Hybridomas were selected by a solid-phase @entity2 membrane-binding immunoassay. The target specificity of the secreted monoclonal antibodies was ascertained by radioimmunoprecipitation analysis and indirect immunofluorescence on various @entity0 @entity2 and normal tissue sections. Monoclonal antibody-secreting hybridomas 48.4.8 and 48.4.2 secreted immunoglobulin that selectively immunoprecipitated polypeptide fragments from @entity0 @entity1 membrane antigens. Hybridoma 9.2.2 secreted antibody that was strongly positive by indirect immunofluorescence on all tested lung @entity5 . Adjacent or intervening normal lung tissue did not display significant immunofluorescence. @entity4 of the lung were negative or focally positive when focal squamous cell differentiation was present. @entity9 were negative. The secreted antibody did not significantly stain three extrapulmonary @entity2 or a variety of normal tissues.

title: Monoclonal antibodies to XXXX @entity1 antigens demonstrated by immunofluorescence and immunoprecipitation.

answer: @entity0


abstract: 1. The effects of sympathetic nerve stimulation on the generation of pacemaker action potentials, recorded from the sino-atrial node of the @entity3 , were determined by using intracellular recording techniques. 2. Trains of stimuli applied to the right stellate ganglion led to an increase in heart rate after a delay of a few seconds. During the initial phase of the @entity1 the rate of discharge of pacemaker action potentials increased and the rate of diastolic depolarization increased, but both the peak diastolic potential and the maximum rate of rise of the action potentials were reduced. During the later phase of the @entity1 the peak diastolic potential, the amplitude of the action potentials, the maximum rate of rise and the rate of repolarization of the action potentials were increased. 3. When membrane potential recordings were made from sino-atrial node cells, in which beating had been abolished by adding the organic @entity0 antagonist @entity2 , sympathetic nerve stimulation initiated excitatory junction potentials (EJPs) which had time courses similar to those of the @entity1 recorded from beating preparations. 4. Although both the @entity1 produced by either sympathetic nerve stimulation or added @entity4 were largely abolished by beta-adrenoceptor antagonists, the membrane potential changes recorded during the responses to sympathetic nerve stimulation or added @entity4 were different. Bath-applied @entity4 caused a @entity1 which was associated with an increase in the amplitudes of pacemaker action potentials, an increase in the peak diastolic potential and a shortening in the duration of pacemaker action potentials. 5. The addition of agents which cause the accumulation of @entity5 in the cytoplasm of the cells produced a @entity1 which was associated with a similar sequence of changes in the membrane potentials to those produced by added @entity4 ; again the membrane potential changes produced by these agents differed from those produced by sympathetic nerve stimulation. 6. The results are discussed in relation to the idea that neurally released @entity4 activates a set of receptors which cause @entity1 by increasing inward current flow during diastole, whereas added @entity4 activates a set of receptors that are linked to a @entity5 -dependent pathway which modifies the properties of some of the voltage-dependent channels involved in pacemaking activity.

title: Effects of sympathetic nerve stimulation on the sino-atrial node of the XXXX .

answer: @entity3


abstract: OBJECTIVE: To present a procedure for establishing treatment guidelines during pregnancy and, as an application of the method, the recommendations for treatment of @entity1 . DESIGN: A preliminary survey was carried out among @entity0 of the study group to determine drug choices for treatment of @entity1 during pregnancy. Literature data on the selected drugs were analyzed. Recommendations for treatment were proposed, taking into account for most efficient agents and the least toxic for the fetus. This draft was submitted to all @entity0 of the study group; criticism and suggestions were gathered. A new draft was evolved and repeatedly submitted to @entity0 until consensus was reached. SETTING: Study group set up in southwestern France, with the help of national experts. @entity0 : Forty-three general practitioners, six gynecologists and/or obstetricians, five pharmacologists, two dermatologists, and an embryologist. RESULTS: The main recommendations for treatment of @entity1 during pregnancy are to begin with topical treatment; emollient bath additives, moisturizing cream, talc. If insufficient, a systemic treatment should be added. @entity5 are prescribed first: @entity3 or @entity6 is used during the first 2 months. From the third month, the same agents can be used, as can @entity7 . The duration of treatment can be up to 10 days. The group's second choice was @entity2 ( @entity4 ) as second-line treatment. CONCLUSIONS: Strategies for treatment of diseases during pregnancy are not always well defined. For many common diseases, very few data are available concerning drug use in pregnant @entity0 . The study group, based on consensus among @entity0 , proposed treatment guidelines.

title: Strategy of treatment of XXXX during pregnancy. The Drugs and Pregnancy Study Group.

answer: @entity1


abstract: We have previously defined four @entity0 @entity3 + peripheral T cell subsets, fractions (Fr.) I-IV, based on expression of the 6C10 and 3G11 determinants (Hayakawa, K. and Hardy, R. R., J. Exp. Med. 1988. 168: 1825). These subsets also show distinctive levels of other cell surface markers: the two minor subsets, Fr. III and Fr. IV, are both @entity7 RBlow/-, @entity6 (Mel-14)- and CD44hi, characteristic of secondary T cells. The patterns and levels of cytokine production by individual cells in each subset were determined by bioassay for @entity4 / @entity1 or @entity2 production after anti- @entity5 stimulation. Our data revealed that these four phenotypically defined subsets largely coincide with clusters of cells showing uniform distinctive cytokine profiles, i.e. @entity4 +/ @entity2 -/ @entity1 - (Fr. I and Fr. II, @entity6 +), @entity8 +/ @entity1 + (Fr. III, @entity6 -), and @entity4 -/ @entity2 low/-/ @entity1 + (Fr. IV, @entity6 -). Besides these subsets, an @entity6 -negative cell subfraction within Fr. II appears to represent a transitional population between the @entity4 +/ @entity2 -/ @entity1 - stage and the @entity8 +/ @entity1 + stage. Taken together, these results demonstrate the presence of two @entity1 + secondary T cell subsets with distinct cytokine production patterns, and show that the majority of @entity1 + cells found in healthy adult laboratory @entity0 co-produce @entity2 , and thus are not typical T helper type 2 cells.

title: Two distinct non-T helper type 2 interleukin-4+ cell subsets in XXXX as revealed by single-cell cytokine analysis.

answer: @entity0


abstract: A variety of agents are used as premedication for upper @entity1 (U.G.E.). To our knowledge, no double blind studies have been performed to compare their value. In this study @entity8 (2 mg i.v.) was compared with @entity5 (t mg i.v.) in 200 consecutive @entity0 undergoing elective U.G.E. The study was randomized and double blind in regard to both endoscopists and @entity0 . All @entity0 were given @entity7 (0.4 mg i.v.) and a throat spray with 2% @entity9 . @entity0 who needed supplemental medication were given @entity5 and excluded from final analysis. A graded questionnaire was recorded by endoscopists and @entity0 after U.G.E., and a further anonymous questionnaire was returned by @entity0 four days later. Statistical analysis revealed that @entity8 was superior at facilitating intubation and providing more relaxation as judged by the endoscopist. @entity0 questionnaires, four days after U.G.E., indicated less distress during intubation and examination with @entity8 . @entity2 , @entity3 , @entity4 and @entity6 were uncommon after either @entity8 or @entity5 .

title: A comparison of XXXX and @entity8 in premedication for upper @entity1 : a randomized double blind controlled study.

answer: @entity5


abstract: A variety of agents are used as premedication for upper @entity1 (U.G.E.). To our knowledge, no double blind studies have been performed to compare their value. In this study @entity8 (2 mg i.v.) was compared with @entity5 (t mg i.v.) in 200 consecutive @entity0 undergoing elective U.G.E. The study was randomized and double blind in regard to both endoscopists and @entity0 . All @entity0 were given @entity7 (0.4 mg i.v.) and a throat spray with 2% @entity9 . @entity0 who needed supplemental medication were given @entity5 and excluded from final analysis. A graded questionnaire was recorded by endoscopists and @entity0 after U.G.E., and a further anonymous questionnaire was returned by @entity0 four days later. Statistical analysis revealed that @entity8 was superior at facilitating intubation and providing more relaxation as judged by the endoscopist. @entity0 questionnaires, four days after U.G.E., indicated less distress during intubation and examination with @entity8 . @entity2 , @entity3 , @entity4 and @entity6 were uncommon after either @entity8 or @entity5 .

title: A comparison of @entity5 and @entity8 in premedication for upper XXXX : a randomized double blind controlled study.

answer: @entity1


abstract: A variety of agents are used as premedication for upper @entity1 (U.G.E.). To our knowledge, no double blind studies have been performed to compare their value. In this study @entity8 (2 mg i.v.) was compared with @entity5 (t mg i.v.) in 200 consecutive @entity0 undergoing elective U.G.E. The study was randomized and double blind in regard to both endoscopists and @entity0 . All @entity0 were given @entity7 (0.4 mg i.v.) and a throat spray with 2% @entity9 . @entity0 who needed supplemental medication were given @entity5 and excluded from final analysis. A graded questionnaire was recorded by endoscopists and @entity0 after U.G.E., and a further anonymous questionnaire was returned by @entity0 four days later. Statistical analysis revealed that @entity8 was superior at facilitating intubation and providing more relaxation as judged by the endoscopist. @entity0 questionnaires, four days after U.G.E., indicated less distress during intubation and examination with @entity8 . @entity2 , @entity3 , @entity4 and @entity6 were uncommon after either @entity8 or @entity5 .

title: A comparison of @entity5 and XXXX in premedication for upper @entity1 : a randomized double blind controlled study.

answer: @entity8


abstract: The effects of intracerebroventricular (i.c.v.) injection of @entity7 , a new antihypertensive agent, on blood pressure and heart rate were investigated and compared with those of @entity6 in anaesthetized @entity0 . The i.c.v. injection of @entity7 or @entity6 induced a decrease in blood pressure and heart rate in doses which were ineffective by an intravenous route. The @entity2 effect of @entity7 was less than that of @entity6 , but the duration of this action was obviously longer than that of @entity6 . A fall in heart rate caused by @entity7 was always less conspicuous than that by @entity6 in equipotent @entity1 doses. Decrease in blood pressure and heart rate caused by the two drugs were inhibited by i.c.v. pretreatment with @entity9 and @entity8 , respectively. These findings suggest that presynaptic and/or postsynaptic alpha-adrenoceptors in the brain may play an important role in the @entity3 and @entity5 produced by @entity7 as well as @entity6 . Furthermore, the uptake mechanism at the presynaptic sites of central noradrenergic neurons may be involved in the mode of @entity3 and bradycardic actions of these two drugs since these effects were abolished by pretreatment with @entity10 , an inhibitor of @entity4 uptake into the presynaptic nerve terminals.

title: [Central @entity3 effects of XXXX in anaesthetised @entity0 (author's transl)].

answer: @entity7


abstract: The effects of intracerebroventricular (i.c.v.) injection of @entity7 , a new antihypertensive agent, on blood pressure and heart rate were investigated and compared with those of @entity6 in anaesthetized @entity0 . The i.c.v. injection of @entity7 or @entity6 induced a decrease in blood pressure and heart rate in doses which were ineffective by an intravenous route. The @entity2 effect of @entity7 was less than that of @entity6 , but the duration of this action was obviously longer than that of @entity6 . A fall in heart rate caused by @entity7 was always less conspicuous than that by @entity6 in equipotent @entity1 doses. Decrease in blood pressure and heart rate caused by the two drugs were inhibited by i.c.v. pretreatment with @entity9 and @entity8 , respectively. These findings suggest that presynaptic and/or postsynaptic alpha-adrenoceptors in the brain may play an important role in the @entity3 and @entity5 produced by @entity7 as well as @entity6 . Furthermore, the uptake mechanism at the presynaptic sites of central noradrenergic neurons may be involved in the mode of @entity3 and bradycardic actions of these two drugs since these effects were abolished by pretreatment with @entity10 , an inhibitor of @entity4 uptake into the presynaptic nerve terminals.

title: [Central @entity3 effects of @entity7 in anaesthetised XXXX (author's transl)].

answer: @entity0


abstract: The effects of intracerebroventricular (i.c.v.) injection of @entity7 , a new antihypertensive agent, on blood pressure and heart rate were investigated and compared with those of @entity6 in anaesthetized @entity0 . The i.c.v. injection of @entity7 or @entity6 induced a decrease in blood pressure and heart rate in doses which were ineffective by an intravenous route. The @entity2 effect of @entity7 was less than that of @entity6 , but the duration of this action was obviously longer than that of @entity6 . A fall in heart rate caused by @entity7 was always less conspicuous than that by @entity6 in equipotent @entity1 doses. Decrease in blood pressure and heart rate caused by the two drugs were inhibited by i.c.v. pretreatment with @entity9 and @entity8 , respectively. These findings suggest that presynaptic and/or postsynaptic alpha-adrenoceptors in the brain may play an important role in the @entity3 and @entity5 produced by @entity7 as well as @entity6 . Furthermore, the uptake mechanism at the presynaptic sites of central noradrenergic neurons may be involved in the mode of @entity3 and bradycardic actions of these two drugs since these effects were abolished by pretreatment with @entity10 , an inhibitor of @entity4 uptake into the presynaptic nerve terminals.

title: [Central XXXX effects of @entity7 in anaesthetised @entity0 (author's transl)].

answer: @entity3


abstract: BACKGROUND: The percentage of working age @entity0 with mild @entity1 has risen. Evidence indicates that even mild @entity1 impact cognition, executive functioning, and daily functioning, consequently affecting participation, quality of life (QoL) and return to work (RTW). OBJECTIVES: (1) Compare cognition, participation and QoL between @entity0 3 months post-mild @entity1 who RTW and those who did not; and (2) To determine the correlates of these variables to RTW of @entity0 3 months post- @entity1 . METHODS: We visited at home 163 @entity1 survivors (117 @entity0 , 46 @entity0 ) 3 months post-mild @entity1 ranging from 50 to 89 years. @entity0 who returned to work (n   =   114) and those who did not (n   =   49). Data collection at home included measures for cognitive status (MoCA), executive functions (EFPT, @entity3 ), @entity2 (GDS), participation (RNL), and QoL (SIS recovery). RESULTS: Significant differences were found between RTW @entity0 and those who did not RTW in measures of cognition, @entity2 , participation and QoL (t   =   2.36 to -   5.62, P   <   0.022-0.001). No difference was found on age or gender. Stepwise regression showed that significant correlates of RTW were participation (RNL), executive functions (EFPT), and QoL (SIS recovery). CONCLUSIONS: To enable RTW after mild @entity1 , participation, executive functions and QoL must be considered in planning interventions.

title: What are the correlates of cognition and participation to return to work after first ever mild XXXX ?

answer: @entity1


abstract: ACTH peptide fragments demonstrate potent neurotrophic effects on peripheral nerves in situ, central neurons in culture, and have been implicated to have effects on central neurons in vivo. @entity3 lesioning of the nigrostriatal system, which depletes the striatum of @entity2 , provides a feasible model of central regeneration in which to test these peptides. Male @entity0 were lesioned unilaterally with @entity4 (8 micrograms/4 microliters), infused into the substantia nigra. They were subsequently treated with 10 micrograms/kg IP of @entity7 [ACTH/MSH(4-9) analogue] or saline every 24 h starting immediately after the infusion and were observed for 2 weeks. Rotational behavior data indicate that @entity7 significantly decreases ipsiversive turning (p < 0.05), induced by @entity6 (2 mg/kg), as well as accelerating the onset of denervation supersensitivity induced by @entity5 (0.05 mg/kg). Evaluation of @entity2 immunohistochemistry, using an anti- @entity1 hydroxylase antibody, demonstrates an enhanced intensity of staining in the @entity7 -treated tissue compared to its saline counterpart. This difference is confirmed and quantified through specific high-affinity @entity2 uptake. @entity2 uptake is about 17% higher in the striata of animals treated with @entity7 . Higher @entity2 uptake levels in these ACTH-treated animals correlate with greater fiber density in this group. Therefore, it appears that treatment with the ACTH/MSH(4-9) analogue @entity7 (10 micrograms/kg/24 h) offers a protective effect from @entity4 lesions in the substantia nigra as well as accelerating various compensatory mechanisms involved in functional recovery.

title: Rapid neurotrophic actions of an ACTH/MSH(4-9) analogue after nigrostriatal XXXX lesioning.

answer: @entity4


abstract: OBJECTIVE: Given the prevalence and complexity of @entity4 , there is a need for measures of disability that (a) provide comprehensive, useful clinical information with regard to @entity0 functioning, and (b) do so as briefly as possible to minimize respondent burden. The primary objective of this study was to reduce the length of a well-known, highly detailed measure of disability, the 136-item @entity6 ( @entity6 ), and develop a psychometrically sound short form for use in @entity4 ( @entity6 for @entity4 , @entity5 ). METHOD: A 2-parameter logistic item response theory model was used to develop the @entity5 in a sample of adults presenting for treatment at an interdisciplinary rehabilitation program (N = 723). Items were assessed for inclusion at the subscale level; poorly contributing items were removed sequentially, and model fit was evaluated at each step until adequate fit was achieved. Finally, linear regressions examined the variance accounted for by the @entity5 in relation to the full-length @entity6 in measures of @entity0 functioning. RESULTS: The @entity5 contains 42 items that yield 7 subscale scores and 2 summary dimension scores, Physical and Psychosocial disability. Acceptable reliability and evidence of convergent and divergent validity were demonstrated for each component. The @entity5 accounted for a similar amount of the variance in measures of @entity3 , @entity2 -related @entity1 , @entity2 acceptance, classes of prescribed analgesics, and @entity2 as the full-length @entity6 . CONCLUSIONS: The @entity5 appears to provide robust clinical information with little loss of association with other key aspects of functioning, while substantially lowering response burden. (PsycINFO Database Record

title: Development of a XXXX -specific version of the @entity6 .

answer: @entity4


abstract: OBJECTIVE: Given the prevalence and complexity of @entity4 , there is a need for measures of disability that (a) provide comprehensive, useful clinical information with regard to @entity0 functioning, and (b) do so as briefly as possible to minimize respondent burden. The primary objective of this study was to reduce the length of a well-known, highly detailed measure of disability, the 136-item @entity6 ( @entity6 ), and develop a psychometrically sound short form for use in @entity4 ( @entity6 for @entity4 , @entity5 ). METHOD: A 2-parameter logistic item response theory model was used to develop the @entity5 in a sample of adults presenting for treatment at an interdisciplinary rehabilitation program (N = 723). Items were assessed for inclusion at the subscale level; poorly contributing items were removed sequentially, and model fit was evaluated at each step until adequate fit was achieved. Finally, linear regressions examined the variance accounted for by the @entity5 in relation to the full-length @entity6 in measures of @entity0 functioning. RESULTS: The @entity5 contains 42 items that yield 7 subscale scores and 2 summary dimension scores, Physical and Psychosocial disability. Acceptable reliability and evidence of convergent and divergent validity were demonstrated for each component. The @entity5 accounted for a similar amount of the variance in measures of @entity3 , @entity2 -related @entity1 , @entity2 acceptance, classes of prescribed analgesics, and @entity2 as the full-length @entity6 . CONCLUSIONS: The @entity5 appears to provide robust clinical information with little loss of association with other key aspects of functioning, while substantially lowering response burden. (PsycINFO Database Record

title: Development of a @entity4 -specific version of the XXXX .

answer: @entity6


abstract: BACKGROUND: During the last two decades, a rising incidence of @entity11 has been observed in the Western world. The prognostic relevance of @entity2 -biological factors, such as DNA ploidy or @entity8 overexpression, for overall survival following complete resection is still unknown. METHODS: In a retrospective study of 80 @entity0 with @entity7 of @entity5 , the prognostic significance of flow cytometric DNA ploidy determination was investigated. Overexpression of @entity8 oncoprotein was studied by immunohistochemical alkaline phosphatase-antialkaline phosphatase staining of @entity6 fixed, paraffin embedded tissue sections of the @entity2 . RESULTS: The rate of @entity9 was 86%. Aneuploidy was significantly correlated with lymph node @entity1 only. @entity8 oncoprotein overexpression of the @entity2 was detected in 15 @entity0 (19%). A significant correlation was seen between @entity8 overexpression and depth of @entity2 invasion, lymph node involvement, distant @entity1 , and status of @entity3 after resection (R category, International Union Against Cancer [UICC], 1987). All @entity2 with @entity8 oncoprotein overexpression were aneuploid. In a multivariate Cox regression analysis for overall survival of those 62 @entity0 (78%) whose @entity2 resection was macroscopically and microscopically complete (R0-UICC), depth of invasion, distant @entity1 , and @entity8 overexpression were independent prognostic factors. The relative risk of @entity4 due to recurrence was nearly identical for @entity0 with either @entity8 oncoprotein overexpression or distant @entity1 : 4.06 (1.4-11.8) and 3.94 (1.6-9.5). In a multivariate Cox regression analysis of the subgroup of lymph node-negative @entity0 (n = 26), the ploidy status of the @entity2 (defined as near-diploid plus tetraploid versus aneuploid plus multiploid) was the only independent prognostic factor for overall survival. CONCLUSIONS: These findings demonstrate that DNA ploidy as well @entity10 - @entity8 oncoprotein overexpression are valuable prognostic factors in @entity0 with @entity7 of @entity2 resection.

title: Prognostic value of DNA ploidy and XXXX oncoprotein overexpression in @entity7 of @entity5 .

answer: @entity8


abstract: BACKGROUND: During the last two decades, a rising incidence of @entity11 has been observed in the Western world. The prognostic relevance of @entity2 -biological factors, such as DNA ploidy or @entity8 overexpression, for overall survival following complete resection is still unknown. METHODS: In a retrospective study of 80 @entity0 with @entity7 of @entity5 , the prognostic significance of flow cytometric DNA ploidy determination was investigated. Overexpression of @entity8 oncoprotein was studied by immunohistochemical alkaline phosphatase-antialkaline phosphatase staining of @entity6 fixed, paraffin embedded tissue sections of the @entity2 . RESULTS: The rate of @entity9 was 86%. Aneuploidy was significantly correlated with lymph node @entity1 only. @entity8 oncoprotein overexpression of the @entity2 was detected in 15 @entity0 (19%). A significant correlation was seen between @entity8 overexpression and depth of @entity2 invasion, lymph node involvement, distant @entity1 , and status of @entity3 after resection (R category, International Union Against Cancer [UICC], 1987). All @entity2 with @entity8 oncoprotein overexpression were aneuploid. In a multivariate Cox regression analysis for overall survival of those 62 @entity0 (78%) whose @entity2 resection was macroscopically and microscopically complete (R0-UICC), depth of invasion, distant @entity1 , and @entity8 overexpression were independent prognostic factors. The relative risk of @entity4 due to recurrence was nearly identical for @entity0 with either @entity8 oncoprotein overexpression or distant @entity1 : 4.06 (1.4-11.8) and 3.94 (1.6-9.5). In a multivariate Cox regression analysis of the subgroup of lymph node-negative @entity0 (n = 26), the ploidy status of the @entity2 (defined as near-diploid plus tetraploid versus aneuploid plus multiploid) was the only independent prognostic factor for overall survival. CONCLUSIONS: These findings demonstrate that DNA ploidy as well @entity10 - @entity8 oncoprotein overexpression are valuable prognostic factors in @entity0 with @entity7 of @entity2 resection.

title: Prognostic value of DNA ploidy and @entity8 oncoprotein overexpression in XXXX of @entity5 .

answer: @entity7


abstract: BACKGROUND: During the last two decades, a rising incidence of @entity11 has been observed in the Western world. The prognostic relevance of @entity2 -biological factors, such as DNA ploidy or @entity8 overexpression, for overall survival following complete resection is still unknown. METHODS: In a retrospective study of 80 @entity0 with @entity7 of @entity5 , the prognostic significance of flow cytometric DNA ploidy determination was investigated. Overexpression of @entity8 oncoprotein was studied by immunohistochemical alkaline phosphatase-antialkaline phosphatase staining of @entity6 fixed, paraffin embedded tissue sections of the @entity2 . RESULTS: The rate of @entity9 was 86%. Aneuploidy was significantly correlated with lymph node @entity1 only. @entity8 oncoprotein overexpression of the @entity2 was detected in 15 @entity0 (19%). A significant correlation was seen between @entity8 overexpression and depth of @entity2 invasion, lymph node involvement, distant @entity1 , and status of @entity3 after resection (R category, International Union Against Cancer [UICC], 1987). All @entity2 with @entity8 oncoprotein overexpression were aneuploid. In a multivariate Cox regression analysis for overall survival of those 62 @entity0 (78%) whose @entity2 resection was macroscopically and microscopically complete (R0-UICC), depth of invasion, distant @entity1 , and @entity8 overexpression were independent prognostic factors. The relative risk of @entity4 due to recurrence was nearly identical for @entity0 with either @entity8 oncoprotein overexpression or distant @entity1 : 4.06 (1.4-11.8) and 3.94 (1.6-9.5). In a multivariate Cox regression analysis of the subgroup of lymph node-negative @entity0 (n = 26), the ploidy status of the @entity2 (defined as near-diploid plus tetraploid versus aneuploid plus multiploid) was the only independent prognostic factor for overall survival. CONCLUSIONS: These findings demonstrate that DNA ploidy as well @entity10 - @entity8 oncoprotein overexpression are valuable prognostic factors in @entity0 with @entity7 of @entity2 resection.

title: Prognostic value of DNA ploidy and @entity8 oncoprotein overexpression in @entity7 of XXXX .

answer: @entity5


abstract: X chromosome mosaicism is usually associated with abnormal sexual development and reproductive performance, such as recurrent @entity2 , primary or secondary @entity3 , @entity1 , and @entity5 . However, there is a paucity of literature which discusses these relationships. From July 1988 to December 1992, a total of 105 couples with a history of recurrent @entity2 from a genetic counseling clinic and 61 @entity0 with a history of @entity5 followed up in reproductive endocrinology clinics were assembled, and chromosomal analysis of peripheral blood lymphocytes was carried out. X chromosome mosaicism was found in six individuals (2.9%) out of the 105 couples with recurrent @entity2 , and in five (8.2%) out of 61 @entity0 with @entity5 . The karyotypes were 45,X/46,XX/47,XXX in five cases, 45,X/46,X in four cases, and 46,XX/47,XXX in two cases. The cases of complex X chromosome mosaicism (45,X/46,XX/47,XXX) presented recurrent @entity2 in four cases and @entity5 in one case. The cases of mosaic @entity4 (45,X/46,XX) presented @entity5 in three cases and recurrent @entity2 in one case. The two cases of mosaic triple-X syndrome (46,XX/47,XXX) presented with @entity5 and recurrent @entity2 , respectively. However, the ratio of mosaic cell lines does not correlate well with the phenotypic manifestations in our cases. Our preliminary data suggest that chromosomal analysis should be done routinely in every couple with recurrent @entity2 and in @entity0 with @entity5 . The reproductive performance of X chromosome mosaicism is highly variable and difficult to define.(ABSTRACT TRUNCATED AT 250 WORDS)

title: X chromosome mosaicism in @entity0 with recurrent XXXX .

answer: @entity5


abstract: X chromosome mosaicism is usually associated with abnormal sexual development and reproductive performance, such as recurrent @entity2 , primary or secondary @entity3 , @entity1 , and @entity5 . However, there is a paucity of literature which discusses these relationships. From July 1988 to December 1992, a total of 105 couples with a history of recurrent @entity2 from a genetic counseling clinic and 61 @entity0 with a history of @entity5 followed up in reproductive endocrinology clinics were assembled, and chromosomal analysis of peripheral blood lymphocytes was carried out. X chromosome mosaicism was found in six individuals (2.9%) out of the 105 couples with recurrent @entity2 , and in five (8.2%) out of 61 @entity0 with @entity5 . The karyotypes were 45,X/46,XX/47,XXX in five cases, 45,X/46,X in four cases, and 46,XX/47,XXX in two cases. The cases of complex X chromosome mosaicism (45,X/46,XX/47,XXX) presented recurrent @entity2 in four cases and @entity5 in one case. The cases of mosaic @entity4 (45,X/46,XX) presented @entity5 in three cases and recurrent @entity2 in one case. The two cases of mosaic triple-X syndrome (46,XX/47,XXX) presented with @entity5 and recurrent @entity2 , respectively. However, the ratio of mosaic cell lines does not correlate well with the phenotypic manifestations in our cases. Our preliminary data suggest that chromosomal analysis should be done routinely in every couple with recurrent @entity2 and in @entity0 with @entity5 . The reproductive performance of X chromosome mosaicism is highly variable and difficult to define.(ABSTRACT TRUNCATED AT 250 WORDS)

title: X chromosome mosaicism in XXXX with recurrent @entity5 .

answer: @entity0