abstract: PURPOSE: Recent innovations in CT enable the evolution from mere morphologic imaging to dynamic and functional testing. We describe our initial experience performing myocardial stress perfusion CT in a clinical population with acute @entity2 . METHODS AND MATERIALS: Myocardial stress perfusion CT was performed on twenty consecutive @entity0 (15 @entity0 , 5 @entity0 ; mean age 65    8 years) who presented with acute @entity2 and were clinically referred for stress/rest SPECT and cardiac MRI. Prior to CT each @entity0 was randomly assigned either to Group A or to Group B in a consecutive order (10 @entity0 per group). Group A underwent @entity3 -stress dynamic real-time myocardial perfusion CT using a novel "shuttle" mode on a 2nd generation dual-source CT. Group B underwent @entity3 -stress first-pass dual-energy myocardial perfusion CT using the same CT scanner in dual-energy mode. Two experienced observers visually analyzed all CT perfusion studies. CT findings were compared with MRI and SPECT. RESULTS: In Group A 149/170 @entity1 (88%) could be evaluated. Real-time perfusion CT (versus SPECT) had 86% (84%) sensitivity, 98% (92%) specificity, 94% (88%) positive predictive value, and 96% (92%) negative predictive value in comparison with perfusion MRI for the detection of myocardial perfusion defects. In Group B all @entity1 were available for analysis. Compared with MRI, dual-energy myocardial perfusion CT (versus SPECT) had 93% (94%) sensitivity, 99% (98%) specificity, 92% (88%) positive predictive value, and 96% (94%) negative predictive value for detecting hypoperfused @entity1 . CONCLUSION: Our results suggest the clinical feasibility of myocardial perfusion CT imaging in @entity0 with acute @entity2 . Compared to MRI and SPECT both, dynamic real-time perfusion CT and first-pass dual-energy perfusion CT showed good agreement for the detection of myocardial perfusion defects.

title: @entity3 -stress dynamic real-time myocardial perfusion CT and XXXX -stress first-pass dual-energy myocardial perfusion CT for the assessment of acute @entity2 : initial results.

answer: @entity3


abstract: Alterations in peripheral nerves are well documented in overt @entity5 but not in @entity4 . We performed electrophysiologic studies to investigate such abnormalities in @entity0 with normal serum total T4 and hyperresponsiveness of TSH to @entity3 , either with normal or high levels of basal circulating TSH. Subjects were divided in three groups: (i) @entity4 Stage I (group () (n = 17, mean age = 39 +/- 34 years), T4 = 9 +/- 0.7 micrograms/dL, TSH = 4.3 +/- 0.4 microU/mL, sTSH post- @entity3 (peak value) = 37.6 +/- 1.6 microU/mL; (ii) @entity4 Stage II (group II) (n = 10, mean age: 43 +/- 6 years), T4 = 7.7 +/- 0.8 microgram/dL, TSH = 20 +/- 5 microU/mL, TSH post- @entity3 > 50 microU/mL; (iii) Control Group (n = 20, mean age 41 +/- 5 years), healthy subjects. All @entity0 and controls were @entity0 . @entity3 test consisted in the i.v. injection of 200 micrograms @entity3 (normal peak value up to 25 microU/mL, normal basal TSH < 5.5 microU/mL. None of the @entity0 had @entity2 or any other @entity1 . We studied the distal motor latencies, motor and sensory amplitudes, and nerve conduction velocities. The motor parameters were measured in the median and external sciatic popliteal (ESP) nerves, and the sensory parameters in the median and sural nerves. In most cases values were obtained from both right and left nerves. Motor parameters: no differences were found between all groups for conduction velocities (CV).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Peripheral neuropathy in XXXX .

answer: @entity4


abstract: @entity3 is the most frequent @entity5 . It is a progressive @entity2 that can lead to substantial bone and joint @entity4 . This progressive disease severely worsens the @entity0 ' quality of life. Over the past 20 years, enzymatic treatment has considerably improved both symptoms and quality of life. Yet, bone and @entity1 may be irreversible. This emphasizes the importance of rigorous follow-up so as to begin uninterrupted treatment before lesion onset. The transition from pediatric to adult care is a major concern for chronic @entity0 . This step is often associated with follow-up problems and may lead to disease worsening. We present three cases of @entity0 who were lost to follow-up during the transition phase. For all 3 @entity0 , the disease notably worsened because follow-up was interrupted during this period.

title: [Difficult transitions from paediatric to adult care in type 1 XXXX ].

answer: @entity3


abstract: OBJECTIVES: The purpose of this work was to statistically evaluate the outcomes achieved by isolated extraction of mandibular teeth (second premolars or first molars) for @entity2 . MATERIALS AND METHODS: Part A of the study dealt with the quality of outcomes at the end of active treatment, using weighted Peer Assessment Rating (PAR) scores determined on the basis of casts for 25 (14 female and 11 male) consecutive @entity0 aged 16        1.7 years at the time of debonding. These results were compared to the scores in a randomly selected control group of 25 (14 female and 11 male) @entity0 who were 14.7        1.9 years old at debonding. Part B evaluated the long-term stability of the outcomes based on 12 (all of them female) @entity0 available for examination after a mean of 11.8 years. The mean weighted PAR scores obtained in both study parts were analyzed for statistical differences using a two-tailed paired Student's t-test at a significance level of p    <=   0.05. RESULTS: Mean weighted PAR scores of 4.76        3.94 and 3.92        3.44 were obtained in the Class III extraction group and the control group, respectively, at the end of active treatment. This difference was not significant (p   =   0.49). Among the 12 longitudinal @entity0 , the mean score increased from 4        3.46 at debonding to 6.25        3.67 by the end of the 11.8-year follow-up period. This difference was significant (p   =   0.0008). CONCLUSION: Treatment of @entity1 by isolated extraction of lower premolars or molars can yield PAR scores similar to those achieved by standard therapies. These scores, while increasing significantly, remained at a clinically acceptable level over 11.8 years. Hence this treatment modality--intended for cases that border on requiring orthognathic surgery--may also be recommended from a long-term point of view.

title: XXXX for skeletal Class III malocclusion by isolated extraction of mandibular teeth. Part 1: Occlusal situation 12 years after completion of active treatment.

answer: @entity2


abstract: Surgical excision of @entity1 metastases is practical only when the number of lesions is small. In some @entity0 isolated limb perfusion is not possible or fails to achieve control, and @entity2 laser ablation is then an alternative treatment. Between September 1992 and September 1994, 19 @entity0 aged 45-94 years were treated with @entity2 laser. Two @entity0 had received no previous limb perfusion, while the remaining 17 had up to three previous perfusions. The number of lesions per @entity0 ranged from three to 40 nodules. A Sharplan 1030 portable @entity2 laser was used, which generates a beam wavelength of 10.6 microns and has a maximum power output of 80 W. All procedures were carried out under general anaesthesia. Each lesion was destroyed with a focused laser beam of 10-20 W with a spot size of 0.5-1.0 mm. At a mean follow-up of 15 months, five @entity0 have died from the disease. Among the 14 survivors, eight have had no limb recurrence of the disease, three have had one further treatment and three a further two treatments to control cutaneous metastases at new sites. Early experience suggests that @entity2 laser ablation of cutaneous metastases is an effective palliative treatment after failed isolated limb perfusion, and there may be a group of @entity0 in whom laser ablation should be the initial treatment of choice.

title: @entity2 laser ablation as an alternative treatment for cutaneous metastases from malignant XXXX .

answer: @entity1


abstract: Surgical excision of @entity1 metastases is practical only when the number of lesions is small. In some @entity0 isolated limb perfusion is not possible or fails to achieve control, and @entity2 laser ablation is then an alternative treatment. Between September 1992 and September 1994, 19 @entity0 aged 45-94 years were treated with @entity2 laser. Two @entity0 had received no previous limb perfusion, while the remaining 17 had up to three previous perfusions. The number of lesions per @entity0 ranged from three to 40 nodules. A Sharplan 1030 portable @entity2 laser was used, which generates a beam wavelength of 10.6 microns and has a maximum power output of 80 W. All procedures were carried out under general anaesthesia. Each lesion was destroyed with a focused laser beam of 10-20 W with a spot size of 0.5-1.0 mm. At a mean follow-up of 15 months, five @entity0 have died from the disease. Among the 14 survivors, eight have had no limb recurrence of the disease, three have had one further treatment and three a further two treatments to control cutaneous metastases at new sites. Early experience suggests that @entity2 laser ablation of cutaneous metastases is an effective palliative treatment after failed isolated limb perfusion, and there may be a group of @entity0 in whom laser ablation should be the initial treatment of choice.

title: XXXX laser ablation as an alternative treatment for cutaneous metastases from malignant @entity1 .

answer: @entity2


abstract: UNASSIGNED: We investigated the association between adulthood weight change and @entity1 risk in a prospective study with 24 to 34 years of follow-up among 90,988 @entity0 and 46,679 @entity0 . The primary exposures included weight change from early adulthood (age = 18 years for @entity0 , 21 years for @entity0 ) to baseline enrollment (median age = 43 years for @entity0 , 52 years for @entity0 ), and from baseline to present. In the secondary analyses, we also assessed 4-year weight change during follow-up, and during premenopausal (from age 18 years to menopause) and postmenopausal (from menopause to present) periods in @entity0 . Compared to @entity0 maintaining their weight from age 21 to baseline, those who gained 20 kg or more were at a higher risk of @entity1 (relative risk [RR], 1.64; 95% confidence interval [CI], 1.15-2.35, P trend < 0.001), whereas those who lost 8 kg or more had a lower risk (RR, 0.61; 95% CI, 0.30-1.22, P trend = 0.003). Similar but weaker associations were found in @entity0 and the corresponding RRs were 1.38 (95% CI, 1.13-1.69, P trend < 0.001) and 0.80 (95% CI, 0.58-1.09, P trend = 0.21). Weight change from baseline to present was not associated with @entity1 risk. Four-year weight change during follow-up was positively associated with @entity1 risk in @entity0 (P trend = 0.03) but not in @entity0 (P trend = 0.42). In addition, in @entity0 , weight change before, but not after, menopause was associated with @entity1 risk. Our findings provide further scientific rationale for recommendations to maintain a healthy body weight during adulthood. A potential differential association according to sex and timing of weight change warrants further investigation. Cancer Prev Res; 8(7); 1-8.   2015 AACR.

title: Adulthood Weight Change and Risk of XXXX in the Nurses' Health Study and Health Professionals Follow-up Study.

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) after major abdominal surgery are common and associated with significant morbidity and high cost of care. The objective of this study was to identify the risk factors for @entity2 after major abdominal surgery. MATERIALS AND METHODS: The American College of Surgeons' National Surgical Quality Improvement Program database from 2005-2012 was queried for @entity0 who underwent major abdominal surgery (esophagectomy, gastrectomy, pacnreatectomy, enterectomy, hepatectomy, colectomy, and proctectomy). Predictors of @entity2 were identified using multivariate logistic regression. RESULTS: Of 165,196 @entity0 who underwent major abdominal surgery 9595 (5.8%) suffered @entity2 ( @entity1 3.2%, prolonged ventilator support >= 48  h 3.0%, and unplanned intubation 2.8%). On multivariate analysis, significant predictors of overall and individual @entity2 include esophagectomy, advanced American Society of Anesthesiology Classification System, dependent functional status, prolonged operative time, age >= 80  y, severe @entity4 , @entity5 , ascites, and smoking. Obesity was not a risk factor. Female gender was overall protective for @entity2 . CONCLUSIONS: @entity2 after abdominal procedures are associated with a number of clinical variables. Esophageal operations and American Society of Anesthesiology Classification System were the strongest predictors. These results provide a framework for identifying @entity0 at risk for developing @entity3 after major abdominal surgery.

title: XXXX after major abdominal surgery: National Surgical Quality Improvement Program analysis.

answer: @entity3


abstract: AIM: To determine how the relative @entity10 contents and metabolic pathways regulate the pharmacological phenotypes in @entity0 with @entity9 after treatment with varying doses of DanHong injection (DHI). METHODS: Adult male @entity0 underwent @entity7 ( @entity7 ), and were injected with DHI (DH-1: 1 mL/kg; DH-2: 2.5 mL/kg; DH-3: 5 mL/kg, and DH-4: 10 mL/kg, iv) daily for 3 d. The @entity1 score, body weights and @entity4 volume were assessed. Serum levels of 20 free @entity5 were determined using HPLC, and the values were transformed through the quantitative analysis of the @entity5 in the serum metabolic spectrum. Multivariate statistical analysis methods (PCA and PLS-DA) and web-based metabolomics tools (MetPa and MetaboAnalyst) were used to analyze the biological data sets for the @entity5 . RESULTS: Administration of DHI dose-dependently decreased cerebral @entity4 volume, and ameliorated @entity1 . A total of 5, 6, 7 and 7 non-overlapping metabolites were identified in the DH-1, DH-2, DH-3, and DH-4 groups, respectively. Eight metabolites were shared between the DHI groups and the vehicle group. In addition, the serum levels of @entity2 , @entity8 and @entity3 increased with increasing DHI dose. A total of 3, 2, 2 and 5 non-overlapping metabolic pathways were identified in the DH-1, DH-2, DH-3 and DH-4 groups, respectively, and @entity12 , @entity3 , @entity6 and @entity11 metabolism were identified as overlapping pathways among the 4 dose groups. CONCLUSION: Overlapping and non-overlapping @entity10 metabolites and metabolic pathways are associated with the dose-dependent neuroprotective effect of DHI.

title: DanHong injection dose-dependently varies XXXX metabolites and metabolic pathways in the treatment of @entity0 with @entity9 .

answer: @entity10


abstract: AIM: To determine how the relative @entity10 contents and metabolic pathways regulate the pharmacological phenotypes in @entity0 with @entity9 after treatment with varying doses of DanHong injection (DHI). METHODS: Adult male @entity0 underwent @entity7 ( @entity7 ), and were injected with DHI (DH-1: 1 mL/kg; DH-2: 2.5 mL/kg; DH-3: 5 mL/kg, and DH-4: 10 mL/kg, iv) daily for 3 d. The @entity1 score, body weights and @entity4 volume were assessed. Serum levels of 20 free @entity5 were determined using HPLC, and the values were transformed through the quantitative analysis of the @entity5 in the serum metabolic spectrum. Multivariate statistical analysis methods (PCA and PLS-DA) and web-based metabolomics tools (MetPa and MetaboAnalyst) were used to analyze the biological data sets for the @entity5 . RESULTS: Administration of DHI dose-dependently decreased cerebral @entity4 volume, and ameliorated @entity1 . A total of 5, 6, 7 and 7 non-overlapping metabolites were identified in the DH-1, DH-2, DH-3, and DH-4 groups, respectively. Eight metabolites were shared between the DHI groups and the vehicle group. In addition, the serum levels of @entity2 , @entity8 and @entity3 increased with increasing DHI dose. A total of 3, 2, 2 and 5 non-overlapping metabolic pathways were identified in the DH-1, DH-2, DH-3 and DH-4 groups, respectively, and @entity12 , @entity3 , @entity6 and @entity11 metabolism were identified as overlapping pathways among the 4 dose groups. CONCLUSION: Overlapping and non-overlapping @entity10 metabolites and metabolic pathways are associated with the dose-dependent neuroprotective effect of DHI.

title: DanHong injection dose-dependently varies @entity10 metabolites and metabolic pathways in the treatment of @entity0 with XXXX .

answer: @entity9


abstract: AIM: To determine how the relative @entity10 contents and metabolic pathways regulate the pharmacological phenotypes in @entity0 with @entity9 after treatment with varying doses of DanHong injection (DHI). METHODS: Adult male @entity0 underwent @entity7 ( @entity7 ), and were injected with DHI (DH-1: 1 mL/kg; DH-2: 2.5 mL/kg; DH-3: 5 mL/kg, and DH-4: 10 mL/kg, iv) daily for 3 d. The @entity1 score, body weights and @entity4 volume were assessed. Serum levels of 20 free @entity5 were determined using HPLC, and the values were transformed through the quantitative analysis of the @entity5 in the serum metabolic spectrum. Multivariate statistical analysis methods (PCA and PLS-DA) and web-based metabolomics tools (MetPa and MetaboAnalyst) were used to analyze the biological data sets for the @entity5 . RESULTS: Administration of DHI dose-dependently decreased cerebral @entity4 volume, and ameliorated @entity1 . A total of 5, 6, 7 and 7 non-overlapping metabolites were identified in the DH-1, DH-2, DH-3, and DH-4 groups, respectively. Eight metabolites were shared between the DHI groups and the vehicle group. In addition, the serum levels of @entity2 , @entity8 and @entity3 increased with increasing DHI dose. A total of 3, 2, 2 and 5 non-overlapping metabolic pathways were identified in the DH-1, DH-2, DH-3 and DH-4 groups, respectively, and @entity12 , @entity3 , @entity6 and @entity11 metabolism were identified as overlapping pathways among the 4 dose groups. CONCLUSION: Overlapping and non-overlapping @entity10 metabolites and metabolic pathways are associated with the dose-dependent neuroprotective effect of DHI.

title: DanHong injection dose-dependently varies @entity10 metabolites and metabolic pathways in the treatment of XXXX with @entity9 .

answer: @entity0


abstract: BACKGROUND: The advent of targeted therapy for @entity1 treatment has brought about a paradigm shift in the clinical management of @entity0 @entity1 . Agents such as @entity6 used for @entity2 -mutant @entity3 or @entity5 for @entity4 , for instance, lead to rapid @entity1 responses. Unfortunately, however, resistance often emerges and renders these agents ineffective after a variable amount of time. The FDA-approved dosing schedules for these drugs were not designed to optimally prevent the emergence of resistance. To this end, we have previously utilized evolutionary mathematical modeling of treatment responses to elucidate the dosing schedules best able to prevent or delay the onset of resistance. Here we expand on our approaches by taking into account dose-dependent mutation rates at which resistant cells emerge. The relationship between the serum drug concentration and the rate at which resistance mutations arise can lead to non-intuitive results about the best dose administration strategies to prevent or delay the emergence of resistance. METHODS: We used mathematical modeling, available clinical trial data, and different considerations of the relationship between mutation rate and drug concentration to predict the effectiveness of different dosing strategies. RESULTS: We designed several distinct measures to interrogate the effects of different treatment dosing strategies and found that a low-dose continuous strategy coupled with high-dose pulses leads to the maximal delay until clinically observable resistance. Furthermore, the response to treatment is robust against different assumptions of the mutation rate as a function of drug concentration. CONCLUSIONS: For new and existing targeted drugs, our methodology can be employed to compare the effectiveness of different dose administration schedules and investigate the influence of changing mutation rates on outcomes.

title: Dose-Dependent Mutation Rates Determine Optimum @entity6 Dosing Strategies for @entity2 Mutant XXXX @entity0 .

answer: @entity3


abstract: BACKGROUND: The advent of targeted therapy for @entity1 treatment has brought about a paradigm shift in the clinical management of @entity0 @entity1 . Agents such as @entity6 used for @entity2 -mutant @entity3 or @entity5 for @entity4 , for instance, lead to rapid @entity1 responses. Unfortunately, however, resistance often emerges and renders these agents ineffective after a variable amount of time. The FDA-approved dosing schedules for these drugs were not designed to optimally prevent the emergence of resistance. To this end, we have previously utilized evolutionary mathematical modeling of treatment responses to elucidate the dosing schedules best able to prevent or delay the onset of resistance. Here we expand on our approaches by taking into account dose-dependent mutation rates at which resistant cells emerge. The relationship between the serum drug concentration and the rate at which resistance mutations arise can lead to non-intuitive results about the best dose administration strategies to prevent or delay the emergence of resistance. METHODS: We used mathematical modeling, available clinical trial data, and different considerations of the relationship between mutation rate and drug concentration to predict the effectiveness of different dosing strategies. RESULTS: We designed several distinct measures to interrogate the effects of different treatment dosing strategies and found that a low-dose continuous strategy coupled with high-dose pulses leads to the maximal delay until clinically observable resistance. Furthermore, the response to treatment is robust against different assumptions of the mutation rate as a function of drug concentration. CONCLUSIONS: For new and existing targeted drugs, our methodology can be employed to compare the effectiveness of different dose administration schedules and investigate the influence of changing mutation rates on outcomes.

title: Dose-Dependent Mutation Rates Determine Optimum @entity6 Dosing Strategies for XXXX Mutant @entity3 @entity0 .

answer: @entity2


abstract: BACKGROUND: The advent of targeted therapy for @entity1 treatment has brought about a paradigm shift in the clinical management of @entity0 @entity1 . Agents such as @entity6 used for @entity2 -mutant @entity3 or @entity5 for @entity4 , for instance, lead to rapid @entity1 responses. Unfortunately, however, resistance often emerges and renders these agents ineffective after a variable amount of time. The FDA-approved dosing schedules for these drugs were not designed to optimally prevent the emergence of resistance. To this end, we have previously utilized evolutionary mathematical modeling of treatment responses to elucidate the dosing schedules best able to prevent or delay the onset of resistance. Here we expand on our approaches by taking into account dose-dependent mutation rates at which resistant cells emerge. The relationship between the serum drug concentration and the rate at which resistance mutations arise can lead to non-intuitive results about the best dose administration strategies to prevent or delay the emergence of resistance. METHODS: We used mathematical modeling, available clinical trial data, and different considerations of the relationship between mutation rate and drug concentration to predict the effectiveness of different dosing strategies. RESULTS: We designed several distinct measures to interrogate the effects of different treatment dosing strategies and found that a low-dose continuous strategy coupled with high-dose pulses leads to the maximal delay until clinically observable resistance. Furthermore, the response to treatment is robust against different assumptions of the mutation rate as a function of drug concentration. CONCLUSIONS: For new and existing targeted drugs, our methodology can be employed to compare the effectiveness of different dose administration schedules and investigate the influence of changing mutation rates on outcomes.

title: Dose-Dependent Mutation Rates Determine Optimum XXXX Dosing Strategies for @entity2 Mutant @entity3 @entity0 .

answer: @entity6


abstract: BACKGROUND: The advent of targeted therapy for @entity1 treatment has brought about a paradigm shift in the clinical management of @entity0 @entity1 . Agents such as @entity6 used for @entity2 -mutant @entity3 or @entity5 for @entity4 , for instance, lead to rapid @entity1 responses. Unfortunately, however, resistance often emerges and renders these agents ineffective after a variable amount of time. The FDA-approved dosing schedules for these drugs were not designed to optimally prevent the emergence of resistance. To this end, we have previously utilized evolutionary mathematical modeling of treatment responses to elucidate the dosing schedules best able to prevent or delay the onset of resistance. Here we expand on our approaches by taking into account dose-dependent mutation rates at which resistant cells emerge. The relationship between the serum drug concentration and the rate at which resistance mutations arise can lead to non-intuitive results about the best dose administration strategies to prevent or delay the emergence of resistance. METHODS: We used mathematical modeling, available clinical trial data, and different considerations of the relationship between mutation rate and drug concentration to predict the effectiveness of different dosing strategies. RESULTS: We designed several distinct measures to interrogate the effects of different treatment dosing strategies and found that a low-dose continuous strategy coupled with high-dose pulses leads to the maximal delay until clinically observable resistance. Furthermore, the response to treatment is robust against different assumptions of the mutation rate as a function of drug concentration. CONCLUSIONS: For new and existing targeted drugs, our methodology can be employed to compare the effectiveness of different dose administration schedules and investigate the influence of changing mutation rates on outcomes.

title: Dose-Dependent Mutation Rates Determine Optimum @entity6 Dosing Strategies for @entity2 Mutant @entity3 XXXX .

answer: @entity0


abstract: OBJECTIVE: To discuss the main influence factors of sound pressure level parameters in @entity0 with simple snoring (SS) and @entity2 ( @entity2 ). METHOD: Eighty-four cases with snoring disease underwent polysomnography and simultaneously snoring sound pressure level recording. The correlations between AHI, age, BMI, abdomen circumference, neck circumference, the lowest @entity1 saturation total @entity3 time and sound pressure level parameters: equivalent continuous sound level(LAeq)and maximum sound pressure level( @entity4 ) were analyzed. RESULT: LAeq was significantly correlated to AHI (P= 0. 000) and BMI (P= 0. 007), and the odd ratios of AHI and BMI were 5. 74,2. 09 respectively, but it was unrelated to age, abdomen circumference, neck circumference, the lowest @entity1 saturation and total @entity3 time. A significantly association also existed between @entity4 and AHI(P=0. 000), BMI(P=0. 032), and the odd ratios were 4. 11 and 2. 33 respectively. Other factors had nothing to do with @entity4 . CONCLUSION: The main factors which affect the snoring sound pressure level parameters LAeq and @entity4 are AHI and BMI.

title: [The influence factors of sound pressure level parameters in @entity0 with simple snoring and XXXX ].

answer: @entity2


abstract: OBJECTIVE: To discuss the main influence factors of sound pressure level parameters in @entity0 with simple snoring (SS) and @entity2 ( @entity2 ). METHOD: Eighty-four cases with snoring disease underwent polysomnography and simultaneously snoring sound pressure level recording. The correlations between AHI, age, BMI, abdomen circumference, neck circumference, the lowest @entity1 saturation total @entity3 time and sound pressure level parameters: equivalent continuous sound level(LAeq)and maximum sound pressure level( @entity4 ) were analyzed. RESULT: LAeq was significantly correlated to AHI (P= 0. 000) and BMI (P= 0. 007), and the odd ratios of AHI and BMI were 5. 74,2. 09 respectively, but it was unrelated to age, abdomen circumference, neck circumference, the lowest @entity1 saturation and total @entity3 time. A significantly association also existed between @entity4 and AHI(P=0. 000), BMI(P=0. 032), and the odd ratios were 4. 11 and 2. 33 respectively. Other factors had nothing to do with @entity4 . CONCLUSION: The main factors which affect the snoring sound pressure level parameters LAeq and @entity4 are AHI and BMI.

title: [The influence factors of sound pressure level parameters in XXXX with simple snoring and @entity2 ].

answer: @entity0


abstract: The entry of lymphocytes into the spleen, in contrast to lymph nodes, does not involve high endothelial venule ( @entity1 ) interaction. The precise point of entry, as well as the mechanism by which lymphocytes enter the lymphoid areas of the spleen, remains controversial. We examined in detail the effect of two agents, pertussis toxin (PT) and the sulfated polysaccharide fucoidan, on splenic lymphocyte entry and positioning. These have previously been shown to interfere with lymphocyte extravasation across @entity1 . PT prevents lymphocyte extravasation, but not binding, to @entity1 , whereas fucoidan prevents binding and thus subsequent extravasation. Studies presented here show that pretreatment of @entity0 lymphocytes with PT does not numerically affect entry into spleen, but profoundly alters lymphocyte positioning within the spleen. When fluorescently labeled, PT-treated lymphocytes are injected intravenously, they initially accumulate in the marginal zone, in apparent association with the layer of marginal zone macrophages (MZM phi) which form a shell around the white pulp. They fail to traverse this layer into the white pulp, and subsequently localize in the red pulp. In contrast, untreated cells initially appear in the marginal zone, then continue to migrate into the white pulp after traversing the MZM phi layer. The localization of PT-pretreated lymphocytes adjacent to the MZM phi layer is disrupted by intravenous administration of fucoidan. Using a flow cytometric assay of aggregation between MZM phi and lymphocytes, we confirmed that fucoidan is also able to inhibit this association in vitro, whereas PT has no effect on this interaction. We propose that MZM phi in the @entity0 are the splenic analog of @entity1 , forming the port of entry of lymphocytes into the white pulp of the spleen.

title: Are XXXX marginal-zone macrophages the splenic white pulp analog of high endothelial venules?

answer: @entity0


abstract: Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight (and therefore reduced intrauterine space) in early gestation compared to late gestation. However, even in late gestation, mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from small fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of @entity0 ( @entity5 , @entity6 , @entity7 ) suggesting that glycosaminoglycan synthesis may compete with the @entity0 needs of the developing fetus. @entity2 conceptuses are fructogenic, such that a substantial portion of @entity0 transferred from mother to fetus is converted to @entity1 . @entity1 is an intermediate product in the synthesis of @entity5 from @entity0 , and @entity5 is linked to regulation of trophoblast cell proliferation through regulation of @entity3 . These findings suggest a link between @entity0 , @entity1 , @entity5 synthesis, GAG production, and placental morphogenesis, but the details of these interactions remain unclear. In addition, recent placental epithelial transcriptome analysis identified several @entity0 , @entity4 , lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the @entity2 fetus, potentially increasing litter size and piglet birth weights.

title: Placental accommodations for transport and metabolism during intra-uterine crowding in XXXX .

answer: @entity2


abstract: OBJECTIVE: To determine the impact of (i) computed tomographic (CT) pelvimetry for the choice of the mode of delivery, (ii) cesarean, (iii) induction of labor, and of (iv) various delivery managements on the risk of @entity2 in @entity4 , with or without @entity1 , and in @entity0 with previous history of @entity2 . METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: In case of clinically suspected @entity4 , a sonography should be performed to increase diagnostic performances and to assist in decision-making (Professional consensus). Because CT pelvimetry is associated with high false positive rates and increases cesarean deliveries, its use is not recommended to prevent @entity2 in @entity4 (Professional consensus). To avoid the neonatal complications of @entity2 , mainly permanent @entity3 , cesarean delivery is recommended in case of estimated fetal weight (EFW) greater than 4500g if associated with @entity1 (gradeC), and greater than 5000g in the absence of @entity1 (gradeC). The published data do not provide definitive evidences to recommend systematic labor induction in case of impending @entity4 (Professional consensus). In case of favourable cervix and gestational age greater than 39 weeks of gestation, labor induction should be promoted (Professional consensus). Prophylactic McRoberts maneuver is not recommended to prevent @entity2 in @entity4 (gradeC). Because data are lacking, no recommendation is possible regarding the use of episiotomy. In @entity4 and failure to progress in the second stage of labor, midpelvic and higher instrumental deliveries are not recommended and a cesarean delivery should be preferred (gradeC), if the fetal head is at or lower than a +2 station, cesarean delivery is not recommended and an instrumental delivery should be preferred (gradeC). Finally, cesarean delivery should be discussed when history of @entity2 has been associated with severe neonatal or maternal complications (Professional consensus). CONCLUSION: To avoid @entity2 and its complications, only two measures are proposed. Induction of labor is recommended in case of impending @entity4 if the cervix is favourable and gestational age greater than 39 weeks of gestation (Professional consensus). Cesarean delivery is recommended before labor in case of (i) EFW greater than 4500g if associated with @entity1 (gradeC), (ii) EFW greater than 5000g in the absence of @entity1 (gradeC), and finally (iii) during labor, in @entity4 and failure to progress in the second stage, when the fetal head is above a +2 station (gradeC). Finally, cesarean delivery should be discussed when history of @entity2 has been associated with severe neonatal or maternal complications (Professional consensus).

title: [Delivery management for the prevention of XXXX in case of identified risk factors].

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) @entity0 may have a reduced functional capacity (FC). Field tests, as the Incremental Shuttle Walk Test (ISWT), can estimate peak @entity1 uptake (VO2 peak). However, the relationship between the ISWT and the Cardiopulmonary Exercise Testing (CPET), the gold standard in the assessment of FC, is not well established in @entity2 @entity0 . AIM: This study aimed to evaluate the FC of @entity2 @entity0 by ISWT with direct measurement of VO2 peak and to compare these findings with data obtained from CPET. A secondary goal was to derive a regression equation to calculate the VO2 peak by ISWT. DESIGN: Cross-sectional and correlative study. SETTING: Research laboratory setting. POPULATION: Thirty-two @entity2 @entity0 (58.8  9.0 years, 81.3% @entity0 ) participated in this study. METHODS: Eligible @entity0 underwent clinical evaluation, echocardiography, CPET by ramp protocol and ISWT according to current guidelines. RESULTS: The distance walked in ISWT showed a positive correlation with VO2 peak from CPET and ISWT (r=0.456, p=0.009 and r=0.869, p<0.001, respectively). In the agreement analysis, the values of the differences between VO2 peak from CPET and ISWT showed absence of bias (mean bias    95% CI and mean -1.29    5.09mL.kg.min). Based in real values of VO2 obtained from ISWT, one equation including sex, functional class and distance walked was provided to predict the VO2 values in this test. CONCLUSION: This study showed the good correlation between distance walked in ISWT and VO2 peak directly measured in both tests, and additionally, provided an equation to calculate a predictive VO2 peak by ISWT, suggesting a good alternative to evaluate the FC of @entity2 @entity0 , especially in locations where sophisticated testing is not available. CLINICAL REHABILITATION IMPACT: The results confirm the possibility of using the ISWT for the evaluation of the FC in @entity0 with @entity2 , especially in locations where sophisticated testing is not available.

title: Peak XXXX uptake during the incremental shuttle walk test in a predominantly female population with @entity2 .

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) @entity0 may have a reduced functional capacity (FC). Field tests, as the Incremental Shuttle Walk Test (ISWT), can estimate peak @entity1 uptake (VO2 peak). However, the relationship between the ISWT and the Cardiopulmonary Exercise Testing (CPET), the gold standard in the assessment of FC, is not well established in @entity2 @entity0 . AIM: This study aimed to evaluate the FC of @entity2 @entity0 by ISWT with direct measurement of VO2 peak and to compare these findings with data obtained from CPET. A secondary goal was to derive a regression equation to calculate the VO2 peak by ISWT. DESIGN: Cross-sectional and correlative study. SETTING: Research laboratory setting. POPULATION: Thirty-two @entity2 @entity0 (58.8  9.0 years, 81.3% @entity0 ) participated in this study. METHODS: Eligible @entity0 underwent clinical evaluation, echocardiography, CPET by ramp protocol and ISWT according to current guidelines. RESULTS: The distance walked in ISWT showed a positive correlation with VO2 peak from CPET and ISWT (r=0.456, p=0.009 and r=0.869, p<0.001, respectively). In the agreement analysis, the values of the differences between VO2 peak from CPET and ISWT showed absence of bias (mean bias    95% CI and mean -1.29    5.09mL.kg.min). Based in real values of VO2 obtained from ISWT, one equation including sex, functional class and distance walked was provided to predict the VO2 values in this test. CONCLUSION: This study showed the good correlation between distance walked in ISWT and VO2 peak directly measured in both tests, and additionally, provided an equation to calculate a predictive VO2 peak by ISWT, suggesting a good alternative to evaluate the FC of @entity2 @entity0 , especially in locations where sophisticated testing is not available. CLINICAL REHABILITATION IMPACT: The results confirm the possibility of using the ISWT for the evaluation of the FC in @entity0 with @entity2 , especially in locations where sophisticated testing is not available.

title: Peak @entity1 uptake during the incremental shuttle walk test in a predominantly female population with XXXX .

answer: @entity2


abstract: OBJECTIVES: To investigate the long-term motor stability and sensory outcome of @entity0 with partly accommodative @entity2 who were overcorrected surgically and in whom the hyperopic correction was reduced postoperatively, and to determine if those results depended on the amount of @entity1 present. DESIGN: A 15-year prospective study that analyzed 5-year outcome. @entity0 whose @entity2 was not initially overcorrected were used as controls. @entity0 : Of 382 @entity0 who underwent surgery for partly accommodative @entity2 , 22 were surgically overcorrected and were followed up for 5 years. RESULTS: Of the eight @entity0 in the study group with 2.5 diopters or less of @entity1 in their fixing eye, seven had good motor alignment compared with four of 14 @entity0 who had more than 2.5 diopters of @entity1 . Ninety-one percent (148/163) of the control @entity0 who had greater than 2.5 diopters of @entity1 maintained good motor alignment 5 years after surgery compared with 29% of the study group @entity0 . This difference was statistically significant. Of the eight study @entity0 with less than 2.5 diopters of @entity1 , five developed good stereopsis compared with one of 14 @entity0 with greater @entity1 . CONCLUSIONS: Surgical overcorrection in @entity0 with partly accommodative @entity2 with greater than 2.5 diopters of @entity1 may not be reversible by postoperative reduction in the hyperopic correction. It often is reversible, however, in @entity0 with 2.5 diopters or less of @entity1 .

title: Partly accommodative XXXX . Should you overcorrect and cut the plus?

answer: @entity2


abstract: [Purpose] @entity1 ( @entity1 ) and @entity3 ( @entity3 ) are a common diseases commonly encountered in physical therapy clinics. There are also @entity0 who have both of these diseases. In this study we aim to investigated whether @entity1 is a risk factor for @entity3 and the frequency of their coincident occurrence. [Subjects and Methods] Thirty-five @entity0 having a primary @entity1 diagnosis according to the American @entity2 Association criteria are taken into consideration and a control group were the subjects of this study. The two groups were compared with respect to cervical disc hernia using cervical region MRI. [Results] The distribution of disc hernia of 6 @entity1 @entity0 who had @entity4 was: 16.6% @entity5 , 16.6% @entity6 , 16.6% C6-7, 33.3% C4-5, @entity6 (two levels in two @entity0 ) and 16.6% C4-5, @entity6 , C7-1 (three levels in one @entity0 ) . The herniation directions were given as: central in 5 levels, right paramedian in 1 level, and left paramedian disc hernia in 1 level. There were 4 cervical disk hernia in the control group. The herniation direction were central in two, right paramedian in one, and left paramedian in one @entity0 . [Conclusion] In this study, the existence of @entity3 in @entity1 @entity0 was found to be not different from the normal population.

title: Concomitance of XXXX syndrome and @entity3 .

answer: @entity1


abstract: [Purpose] @entity1 ( @entity1 ) and @entity3 ( @entity3 ) are a common diseases commonly encountered in physical therapy clinics. There are also @entity0 who have both of these diseases. In this study we aim to investigated whether @entity1 is a risk factor for @entity3 and the frequency of their coincident occurrence. [Subjects and Methods] Thirty-five @entity0 having a primary @entity1 diagnosis according to the American @entity2 Association criteria are taken into consideration and a control group were the subjects of this study. The two groups were compared with respect to cervical disc hernia using cervical region MRI. [Results] The distribution of disc hernia of 6 @entity1 @entity0 who had @entity4 was: 16.6% @entity5 , 16.6% @entity6 , 16.6% C6-7, 33.3% C4-5, @entity6 (two levels in two @entity0 ) and 16.6% C4-5, @entity6 , C7-1 (three levels in one @entity0 ) . The herniation directions were given as: central in 5 levels, right paramedian in 1 level, and left paramedian disc hernia in 1 level. There were 4 cervical disk hernia in the control group. The herniation direction were central in two, right paramedian in one, and left paramedian in one @entity0 . [Conclusion] In this study, the existence of @entity3 in @entity1 @entity0 was found to be not different from the normal population.

title: Concomitance of @entity1 syndrome and XXXX .

answer: @entity3


abstract: Angiotensin receptor blockers (ARBs) have organ-protective effects in @entity3 and may be also effective in @entity2 -induced @entity1 (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, @entity5 , in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle ( @entity4 -only group, n=22), 5 mg/kg of @entity5 (Low-fima group, n=22), and 10 mg/kg of @entity5 (High-fima group, n=19). @entity4 was injected once a week for six weeks. Echocardiography and hemodynamic assessment was performed at the 8th week using a miniaturized conductance catheter. Survival rate of the High-fima group was greater (100%) than that of the Low-fima (75%) and @entity4 -only groups (50%). Echocardiography showed preserved left ventricular (LV) ejection fraction in the High-fima group, but not in the @entity4 -only group (P=0.002). LV dimensions increased in the @entity4 -only group; however, remodeling was attenuated in the Low-fima and High-fima groups. Hemodynamic assessment showed higher dP/dt in the High-fima group compared with the @entity4 -only group. A novel ARB, @entity5 , may prevent @entity4 -CMP and improve survival rate in a dose-dependent manner in a @entity0 model of DOX-CMP and could be a treatment option for the prevention of DOX-CMP.

title: A Novel Angiotensin Type I Receptor Antagonist, XXXX , Prevents @entity2 -induced Cardiotoxicity in @entity0 .

answer: @entity5


abstract: Angiotensin receptor blockers (ARBs) have organ-protective effects in @entity3 and may be also effective in @entity2 -induced @entity1 (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, @entity5 , in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle ( @entity4 -only group, n=22), 5 mg/kg of @entity5 (Low-fima group, n=22), and 10 mg/kg of @entity5 (High-fima group, n=19). @entity4 was injected once a week for six weeks. Echocardiography and hemodynamic assessment was performed at the 8th week using a miniaturized conductance catheter. Survival rate of the High-fima group was greater (100%) than that of the Low-fima (75%) and @entity4 -only groups (50%). Echocardiography showed preserved left ventricular (LV) ejection fraction in the High-fima group, but not in the @entity4 -only group (P=0.002). LV dimensions increased in the @entity4 -only group; however, remodeling was attenuated in the Low-fima and High-fima groups. Hemodynamic assessment showed higher dP/dt in the High-fima group compared with the @entity4 -only group. A novel ARB, @entity5 , may prevent @entity4 -CMP and improve survival rate in a dose-dependent manner in a @entity0 model of DOX-CMP and could be a treatment option for the prevention of DOX-CMP.

title: A Novel Angiotensin Type I Receptor Antagonist, @entity5 , Prevents XXXX -induced Cardiotoxicity in @entity0 .

answer: @entity2


abstract: Angiotensin receptor blockers (ARBs) have organ-protective effects in @entity3 and may be also effective in @entity2 -induced @entity1 (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, @entity5 , in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle ( @entity4 -only group, n=22), 5 mg/kg of @entity5 (Low-fima group, n=22), and 10 mg/kg of @entity5 (High-fima group, n=19). @entity4 was injected once a week for six weeks. Echocardiography and hemodynamic assessment was performed at the 8th week using a miniaturized conductance catheter. Survival rate of the High-fima group was greater (100%) than that of the Low-fima (75%) and @entity4 -only groups (50%). Echocardiography showed preserved left ventricular (LV) ejection fraction in the High-fima group, but not in the @entity4 -only group (P=0.002). LV dimensions increased in the @entity4 -only group; however, remodeling was attenuated in the Low-fima and High-fima groups. Hemodynamic assessment showed higher dP/dt in the High-fima group compared with the @entity4 -only group. A novel ARB, @entity5 , may prevent @entity4 -CMP and improve survival rate in a dose-dependent manner in a @entity0 model of DOX-CMP and could be a treatment option for the prevention of DOX-CMP.

title: A Novel Angiotensin Type I Receptor Antagonist, @entity5 , Prevents @entity2 -induced Cardiotoxicity in XXXX .

answer: @entity0


abstract: BACKGROUND/AIM: One of the factors known to contribute to a 'good life' following an acquired disability is making connections with others, often achieved through participation in activities outside the home. The majority of outcomes research following SCI has focussed on impairments and activity limitations with less emphasis on participation. This paper reports part of a larger study that explored the experience and meaning of @entity1 following SCI. The research question guiding the part of the study reported in this paper was: What are the facilitators and barriers to @entity1 following acquired SCI? METHODS: Semi-structured interviews were conducted with 17 adults with traumatically acquired @entity2 living in the community. Interviews were audio-recorded, transcribed verbatim and analysed using thematic analysis. RESULTS: Three main themes and 11 subthemes were identified. The main themes were: Resources and environmental accessibility impact social participation; other @entity0 influence community engagement; health issues affect social participation. Adequate financial resources and social support (from friends and family, and from peer mentors) were found to assist social participation, while the physical environment, unsupportive social attitudes and mental health issues were identified as barriers to community participation. CONCLUSIONS: This study contributes to the evidence base regarding outcomes following SCI. Enabling engagement in meaningful activities in the community must be at the forefront of occupational therapy intervention, both at an individual client level and through advocacy and policy involvement, to improve the quality of life of @entity0 with SCI living in the community.

title: Facilitators and barriers to XXXX following @entity2 .

answer: @entity1


abstract: BACKGROUND/AIM: One of the factors known to contribute to a 'good life' following an acquired disability is making connections with others, often achieved through participation in activities outside the home. The majority of outcomes research following SCI has focussed on impairments and activity limitations with less emphasis on participation. This paper reports part of a larger study that explored the experience and meaning of @entity1 following SCI. The research question guiding the part of the study reported in this paper was: What are the facilitators and barriers to @entity1 following acquired SCI? METHODS: Semi-structured interviews were conducted with 17 adults with traumatically acquired @entity2 living in the community. Interviews were audio-recorded, transcribed verbatim and analysed using thematic analysis. RESULTS: Three main themes and 11 subthemes were identified. The main themes were: Resources and environmental accessibility impact social participation; other @entity0 influence community engagement; health issues affect social participation. Adequate financial resources and social support (from friends and family, and from peer mentors) were found to assist social participation, while the physical environment, unsupportive social attitudes and mental health issues were identified as barriers to community participation. CONCLUSIONS: This study contributes to the evidence base regarding outcomes following SCI. Enabling engagement in meaningful activities in the community must be at the forefront of occupational therapy intervention, both at an individual client level and through advocacy and policy involvement, to improve the quality of life of @entity0 with SCI living in the community.

title: Facilitators and barriers to @entity1 following XXXX .

answer: @entity2


abstract: OBJECTIVE: This study was designed to estimate the clinical significance of the @entity7 for prediction of postoperative survival in @entity0 with @entity2 ( @entity2 ). BACKGROUND: The @entity8 ( @entity8 ), calculated from the serum levels of @entity6 and albumin, is well known to be a valuable @entity3 -based prognostic system for several types of @entity1 . A recent study has demonstrated that the @entity7 is also useful for prediction of treatment outcome in @entity0 with @entity4 . METHODS: Uni- and multivariate analyses using the Cox proportional hazards model were performed to detect the clinical characteristics that were most closely associated with @entity5 ( @entity5 ). All recommended cutoff values were defined using receiver operating characteristic curve analyses. Kaplan-Meier analysis was used to compare @entity5 curves between the two groups. RESULTS: A total of 627 @entity0 who had undergone elective @entity2 surgery were enrolled. Multivariate analysis using the results of univariate analyses demonstrated that @entity7 (>0.038/ <=0.038) was associated with @entity5 (hazard ratio 2.596; 95  % confidence interval 1.603-4.204; P  <  0.001) along with pathological differentiation (others/well or moderately), carcinoembryonic antigen level (>8.7/ <=8.7, ng/ml), stage (III, IV/0, I, II), neutrophil to lymphocyte ratio (NLR) (>2.9/ <=2.9), and @entity8 (2/0, 1). Kaplan-Meier analysis and log rank test demonstrated a significant difference in @entity5 curves between @entity0 with low @entity7 ( <=0.038) and those with high @entity7 (>0.038; P  <  0.001). CONCLUSIONS: @entity7 is as useful for predicting the postoperative survival of @entity0 with @entity2 as previously reported @entity3 -based prognostic systems, such as @entity8 and NLR.

title: Clinical Significance of the XXXX to Albumin Ratio for Survival After Surgery for @entity2 .

answer: @entity6


abstract: OBJECTIVE: This study was designed to estimate the clinical significance of the @entity7 for prediction of postoperative survival in @entity0 with @entity2 ( @entity2 ). BACKGROUND: The @entity8 ( @entity8 ), calculated from the serum levels of @entity6 and albumin, is well known to be a valuable @entity3 -based prognostic system for several types of @entity1 . A recent study has demonstrated that the @entity7 is also useful for prediction of treatment outcome in @entity0 with @entity4 . METHODS: Uni- and multivariate analyses using the Cox proportional hazards model were performed to detect the clinical characteristics that were most closely associated with @entity5 ( @entity5 ). All recommended cutoff values were defined using receiver operating characteristic curve analyses. Kaplan-Meier analysis was used to compare @entity5 curves between the two groups. RESULTS: A total of 627 @entity0 who had undergone elective @entity2 surgery were enrolled. Multivariate analysis using the results of univariate analyses demonstrated that @entity7 (>0.038/ <=0.038) was associated with @entity5 (hazard ratio 2.596; 95  % confidence interval 1.603-4.204; P  <  0.001) along with pathological differentiation (others/well or moderately), carcinoembryonic antigen level (>8.7/ <=8.7, ng/ml), stage (III, IV/0, I, II), neutrophil to lymphocyte ratio (NLR) (>2.9/ <=2.9), and @entity8 (2/0, 1). Kaplan-Meier analysis and log rank test demonstrated a significant difference in @entity5 curves between @entity0 with low @entity7 ( <=0.038) and those with high @entity7 (>0.038; P  <  0.001). CONCLUSIONS: @entity7 is as useful for predicting the postoperative survival of @entity0 with @entity2 as previously reported @entity3 -based prognostic systems, such as @entity8 and NLR.

title: Clinical Significance of the @entity6 to Albumin Ratio for Survival After Surgery for XXXX .

answer: @entity2


abstract: OBJECTIVE: In this study, we aimed to determine the significance of the staging systems (EORTC, De Groot, MACIS, and @entity4 ) on the prognosis of @entity2 @entity0 who underwent surgery in our clinics. MATERIAL AND METHODS: This retrospective study included 181 @entity0 who were operated between December 1995-December 2007, with a diagnosis of @entity2 . In order to obtain data related to @entity1 staging, a computer program for @entity3 was developed to facilitate parameter recording. Survival analysis was performed. The findings were compared to the predicted rates by the staging systems. RESULTS: According to the De Groot staging system, stage 1 and stage 2 @entity0 ' results were compatible, but stage 3 and 4 @entity0 ' results were different (stage 3; 87% versus 66.6%, stage 4; 35% versus 100%, p=0.04). In the MACIS staging system, 20-year survival rates are determined and comparison should not be made due to insufficient follow-up period in this study. When compared to the EORTC staging system, stage 3 and stage 4 @entity0 ' results were determined different (stage 3; 51% versus 100%, stage 4; 33% versus 50%, p=0.02). The most consistent results in terms of prognosis was determined in comparison with the @entity4 staging system (stage 1; 100% versus 97.8%, stage 4; 45.3% versus 50%). CONCLUSION: Many classification systems are proposed for @entity2 , to predict the behavior of the @entity1 . In this study, we concluded that for determination of prognosis in @entity2 , the @entity4 staging system could best predict prognosis consistent with clinical findings.

title: The importance of staging systems for the determination of prognosis of XXXX .

answer: @entity2


abstract: Preclinical evidence suggests that anesthetic agents harm the developing brain thereby causing long-term @entity2 . It is not clear if these findings apply to @entity0 , and retrospective epidemiological studies thus far have failed to show definitive evidence that anesthetic agents are harmful to the developing @entity0 brain. AIM: The aim of this systematic review was to summarize the preclinical studies published over the past decade, with a focus on methodological issues, to facilitate the comparison between different preclinical studies and inform better design of future trials. METHOD: The literature search identified 941 articles related to the topic of @entity3 . As the primary aim of this systematic review was to compare methodologies applied in animal studies to inform future trials, we excluded a priori all articles focused on putative mechanism of @entity3 and the neuroprotective agents. Forty-seven preclinical studies were finally included in this review. RESULTS: Methods used in these studies were highly heterogeneous-animals were exposed to anesthetic agents at different developmental stages, in various doses and in various combinations with other drugs, and overall showed diverse @entity1 profiles. Physiological monitoring and maintenance of physiological homeostasis was variable and the use of cognitive tests was generally limited to assessment of specific brain areas, with restricted translational relevance to @entity0 . CONCLUSION: Comparison between studies is thus complicated by this heterogeneous methodology and the relevance of the combined body of literature to @entity0 remains uncertain. Future preclinical studies should use better standardized methodologies to facilitate transferability of findings from preclinical into clinical science.

title: A systematic review of methodology applied during preclinical anesthetic XXXX studies: important issues and lessons relevant to the design of future clinical research.

answer: @entity3


abstract: OBJECTIVE: Completion thyroidectomy is recommended in @entity0 who have been diagnosed with @entity4 on histopathological evaluation, if their first operation was a conservative approach. The critical issue is when to do the second operation. MATERIAL AND METHODS: The medical records of 66 @entity0 who underwent completion thyroidectomy for the treatment of @entity4 in our clinic between 2006-2013 were retrospectively analyzed. All data were compared after @entity0 were divided into two groups according to the interval between the first surgery and completion thyroidectomy. RESULTS: Fifty-two @entity0 (78.8%) were @entity0 and 14 @entity0 (21.2%) were male. Completion thyroidectomy was performed 10-90 days after the initial surgery (group 1) in 26 @entity0 , whereas it was performed later than 90 days in 40 @entity0 (group 2). @entity5 occurred in two @entity0 (7.7%) in group 1, and in 3 @entity0 (7.5%) in group 2. Transient recurrent @entity6 was observed in 1 @entity0 (3.9%) in group 1, and in 1 @entity0 (2.5%) in group 2. There were no permanent morbidities in both groups. @entity3 rate after completion thyroidectomy was 45.5%. There was no statistically significant difference between the two groups in terms of complications after completion thyroidectomy. CONCLUSION: Although in some studies it is recommended that completion thyroidectomy should be performed either before scar tissue development or after clinical remission of scar tissue, @entity1 and @entity2 , we believe that timing of surgery has no effect on morbidity.

title: Completion thyroidectomy in XXXX : When to perform?

answer: @entity4


abstract: OBJECTIVE: The aim was to evaluate the parameters that were considered by Forensic Medicine in @entity2 as well as the issues that the physicians were found to be faulty. MATERIAL AND METHODS: The following parameters were investigated in 21 files that were referred to Istanbul Forensic Medicine Institute with request of expert opinion between 2008-2012; expert decisions, @entity0 's age, gender, written @entity0 consent, diagnosis, type of first surgery, surgical complications, timing of complication diagnosis within the scope of complication management, @entity0 's referral timing, troubleshooting procedures and mortality rate. RESULTS: Physicians were found to be faulty in all files. The reason for physician fault was failure to show the necessary professional care and attention in one (4.7%) file, late recognition of @entity1 @entity0 in 20 (95.3%) files. Written consent had not been obtained in any of the files. Thirteen @entity0 were female (61.9%) and 8 (30.1%) were male, with a mean age of 43.3 years. Nineteen @entity0 had @entity3 (90.4%), and two @entity0 (9.5%) had a mass in the head of the pancreas. Cholecystectomy was performed laparoscopically in 15 @entity0 (78.9%), and with open surgery in 4 @entity0 (21.1%). The Whipple procedure was performed in two @entity0 . The diagnosis was made during the operation in one @entity0 (4.7%), and in the post-operative period in 20 @entity0 (95.3%). The time to diagnosis after surgery was between 3-6 days. All of the @entity0 had been referred to third level health care facilities. The timing of transfer was 1 day in the @entity0 who was diagnosed during the operation, and ranged between 4-10 days in those who were diagnosed postoperatively. Reasons for late referral were delays related to pending test results in 12 @entity0 , vague signs in 3 @entity0 , and following-up @entity0 with the thought that the @entity4 will heal by itself in 5 @entity0 . Mortality was not observed in any of the examined files. CONCLUSION: The issues where physicians were most frequently found to be faulty were failure to obtain written @entity0 consent, late recognition of @entity1 @entity0 .

title: The retrospective documentation of legal cases with XXXX that were submitted for consideration to   stanbul Forensic Medicine Institute by the courts between 2008-2012.

answer: @entity2


abstract: A 53-year-old male who was being followed up by a nephrology department because of type V crescentic @entity5 was admitted with abdominal @entity1 to our clinic. He was diagnosed with @entity6 after the examinations. Aortic repair with a tubular graft was performed. Pathological examination of the @entity4 tissue showed @entity3 . We started antifungal chemotherapy with @entity7 . A separation of the graft body occurred, and the @entity0 was reoperated on. An excision of the graft, ligation of the aorta, and axillobifemoral graft by-pass was performed. At the 15(th) month of his discharge, the @entity0 was readmitted to the emergency room of our clinic suffering from hematemesis. According to the examinations, an aortoduodenal @entity2 was diagnosed, and we performed a partial duodenal resection and end-to-end duodenoduodenostomy. We want to share this unusual, interesting, and complicated case, operated on several times because of a @entity8 due to a @entity3 .

title: A real @entity8 of the abdominal aorta due to XXXX .

answer: @entity3


abstract: A 53-year-old male who was being followed up by a nephrology department because of type V crescentic @entity5 was admitted with abdominal @entity1 to our clinic. He was diagnosed with @entity6 after the examinations. Aortic repair with a tubular graft was performed. Pathological examination of the @entity4 tissue showed @entity3 . We started antifungal chemotherapy with @entity7 . A separation of the graft body occurred, and the @entity0 was reoperated on. An excision of the graft, ligation of the aorta, and axillobifemoral graft by-pass was performed. At the 15(th) month of his discharge, the @entity0 was readmitted to the emergency room of our clinic suffering from hematemesis. According to the examinations, an aortoduodenal @entity2 was diagnosed, and we performed a partial duodenal resection and end-to-end duodenoduodenostomy. We want to share this unusual, interesting, and complicated case, operated on several times because of a @entity8 due to a @entity3 .

title: A real XXXX of the abdominal aorta due to @entity3 .

answer: @entity8


abstract: AIM: To compare @entity1 ( @entity1 ) of @entity0 with @entity2 with healthy controls and investigate the correlations between retinal nerve fiber layer (RNFL) thickness parameters and @entity1 . METHODS: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All @entity0 underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera (Topcon 501X). @entity1 were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal, temporal and average RNFL thicknesses were recorded. @entity1 and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation tests. RESULTS: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group (P=0.009, P=0.038, respectively). No statistically significant difference regarding @entity1 was found between two groups. CONCLUSION: @entity1 seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and @entity1 show significant correlations in both groups. This correlation doesn't seem to be specific to PSX.

title: Retinal vessel diameters and their correlation with retinal nerve fiber layer thickness in @entity0 with XXXX .

answer: @entity2


abstract: AIM: To compare @entity1 ( @entity1 ) of @entity0 with @entity2 with healthy controls and investigate the correlations between retinal nerve fiber layer (RNFL) thickness parameters and @entity1 . METHODS: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All @entity0 underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera (Topcon 501X). @entity1 were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal, temporal and average RNFL thicknesses were recorded. @entity1 and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation tests. RESULTS: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group (P=0.009, P=0.038, respectively). No statistically significant difference regarding @entity1 was found between two groups. CONCLUSION: @entity1 seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and @entity1 show significant correlations in both groups. This correlation doesn't seem to be specific to PSX.

title: Retinal vessel diameters and their correlation with retinal nerve fiber layer thickness in XXXX with @entity2 .

answer: @entity0


abstract: BACKGROUND: Malignant @entity2 with osteoclast-like giant cells are rare. A literature search showed 17 previously reported cases that included the following: (1) 8 undifferentiated @entity3 , (2) 5 @entity1 with osteoclast-like giant cells associated with @entity5 or @entity4 , and (3) 4 @entity1 with osteoclast-like giant cells associated with areas of a @entity3 . CASE PRESENTATION: A 68-year-old @entity0 presented with a @entity1 of the right lobe of the liver on ultrasonography and computed tomography. Laparoscopy showed a @entity1 (diameter, 4  cm) in segments 7 and 8 of the right liver lobe that adhered to the retroperitoneum. The @entity1 recurred 3  months after liver segmentectomy. Repeat laparoscopy showed diffuse and nodular metastases to the omentum and peritoneum. RESULT: Light microscopy showed that part of the @entity1 had features of classic @entity3 . Another part of the @entity1 had a solid sarcomatous pattern with osteoclast-like giant cells that were irregularly distributed between the smaller undifferentiated @entity1 cells; cells of this part of the @entity1 were positive for heppar-1. CONCLUSION: Light microscopic findings including osteoclast-like giant cells, and the strong reaction of heppar-1 antibody with cells of the sarcomatous part of the @entity1 , confirmed that this sarcomatous element was a metaplastic or transformed portion of @entity3 . VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6000512901462616.

title: Immunohistochemical evaluation of a XXXX with osteoclastlike giant cells.

answer: @entity3


abstract: We tested whether cardiac mass can be related to decreased @entity4 in an original @entity0 model of isolated systolic @entity1 . Increased @entity4 was produced by @entity2 overload of elastic arteries after @entity6 plus @entity3 treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor @entity7 (1 mg/kg per day PO). @entity0 were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by @entity5 infusion, and carotidofemoral pulse wave velocity was measured. This value together with those for thoracic aorta internal diameter and medial thickness (determined after in situ fixation and histomorphometry) were used to calculate elastic modulus. @entity6 plus @entity3 treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two. There was no significant change in resistance. Treatment with @entity7 reversed the changes in cardiac mass and elastic modulus but had no effect on resistance after @entity2 overload of the elastic arteries. In this model of isolated systolic @entity1 , we showed that cardiac mass is related to arterial elasticity.

title: @entity4 and left ventricular mass in a @entity0 model of isolated systolic XXXX .

answer: @entity1


abstract: We tested whether cardiac mass can be related to decreased @entity4 in an original @entity0 model of isolated systolic @entity1 . Increased @entity4 was produced by @entity2 overload of elastic arteries after @entity6 plus @entity3 treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor @entity7 (1 mg/kg per day PO). @entity0 were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by @entity5 infusion, and carotidofemoral pulse wave velocity was measured. This value together with those for thoracic aorta internal diameter and medial thickness (determined after in situ fixation and histomorphometry) were used to calculate elastic modulus. @entity6 plus @entity3 treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two. There was no significant change in resistance. Treatment with @entity7 reversed the changes in cardiac mass and elastic modulus but had no effect on resistance after @entity2 overload of the elastic arteries. In this model of isolated systolic @entity1 , we showed that cardiac mass is related to arterial elasticity.

title: XXXX and left ventricular mass in a @entity0 model of isolated systolic @entity1 .

answer: @entity4


abstract: We tested whether cardiac mass can be related to decreased @entity4 in an original @entity0 model of isolated systolic @entity1 . Increased @entity4 was produced by @entity2 overload of elastic arteries after @entity6 plus @entity3 treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor @entity7 (1 mg/kg per day PO). @entity0 were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by @entity5 infusion, and carotidofemoral pulse wave velocity was measured. This value together with those for thoracic aorta internal diameter and medial thickness (determined after in situ fixation and histomorphometry) were used to calculate elastic modulus. @entity6 plus @entity3 treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two. There was no significant change in resistance. Treatment with @entity7 reversed the changes in cardiac mass and elastic modulus but had no effect on resistance after @entity2 overload of the elastic arteries. In this model of isolated systolic @entity1 , we showed that cardiac mass is related to arterial elasticity.

title: @entity4 and left ventricular mass in a XXXX model of isolated systolic @entity1 .

answer: @entity0


abstract: RNA-Seq is an efficient way to comprehensively identify single nucleotide polymorphisms (SNPs) and @entity0 ( @entity0 ) events from the expressed genes. In this study, we conducted transcriptome sequencing of four Asian lotus ( @entity1 ) cultivars using Illumina HiSeq2000 platform to identify SNPs and @entity0 events in lotus. A total of 505 million pair-end RNA-Seq reads were generated from four cultivars, of which 86% were mapped to the lotus reference genome. Using the four sets of data together, a total of 357,689 putative SNPs were identified with an average density of one SNP per 2.2 kb. These SNPs were located in 1,253 scaffolds and 15,016 expressed genes. A/G and C/T were the two major types of SNPs in the Asian lotus transcriptome. In parallel, a total of 177,540 @entity0 events were detected in the four cultivars and were distributed in 64% of the expressed genes of lotus. The predominant type of @entity0 events was alternative 5' first exon, which accounted for 41.2% of all the observed @entity0 events, and exon skipping only accounted for 4.3% of all @entity0 . Gene Ontology analysis was conducted to analyze the function of the genes containing SNPs and @entity0 events. Validation of selected SNPs and @entity0 events revealed that 74% of SNPs and 80% of @entity0 events were reliable, which indicates that RNA-Seq is an efficient approach to uncover gene-associated SNPs and @entity0 events. A large number of SNPs and @entity0 events identified in our study will facilitate further genetic and functional genomics research in lotus.

title: RNA-Seq Uncovers SNPs and Alternative Splicing Events in Asian Lotus ( XXXX ).

answer: @entity1


abstract: Azaspiracid (AZA) @entity6 was unknown until 1995 when shellfish harvested in Ireland caused @entity2 manifesting by @entity4 and @entity3 . Further in vivo/vitro studies showed @entity5 linked with AZA exposure. However, the biological target of the toxin which will help explain such potent @entity1 is still unknown. A region of Irish coastline was selected and shellfish were sampled and tested for AZA using mass spectrometry. An outbreak was identified in 2010 and samples collected before and after the contamination episode were compared for their metabolite profile using high resolution mass spectrometry. Twenty eight ions were identified at higher concentration in the contaminated samples. Stringent bioinformatic analysis revealed putative identifications for seven compounds including, glutarylcarnitine, a glutaric acid metabolite. Glutaric acid, the parent compound linked with @entity0 neurological manifestations was subjected to toxicological investigations but was found to have no specific effect on the sodium channel (as was the case with AZA). However in combination, glutaric acid (1mM) and azaspiracid (50nM) inhibited the activity of the sodium channel by over 50%. Glutaric acid was subsequently detected in all shellfish employed in the study. For the first time a viable mechanism for how AZA manifests itself as a toxin is presented.

title: New insights into the causes of @entity0 XXXX due to consumption of azaspiracid contaminated shellfish.

answer: @entity2


abstract: Azaspiracid (AZA) @entity6 was unknown until 1995 when shellfish harvested in Ireland caused @entity2 manifesting by @entity4 and @entity3 . Further in vivo/vitro studies showed @entity5 linked with AZA exposure. However, the biological target of the toxin which will help explain such potent @entity1 is still unknown. A region of Irish coastline was selected and shellfish were sampled and tested for AZA using mass spectrometry. An outbreak was identified in 2010 and samples collected before and after the contamination episode were compared for their metabolite profile using high resolution mass spectrometry. Twenty eight ions were identified at higher concentration in the contaminated samples. Stringent bioinformatic analysis revealed putative identifications for seven compounds including, glutarylcarnitine, a glutaric acid metabolite. Glutaric acid, the parent compound linked with @entity0 neurological manifestations was subjected to toxicological investigations but was found to have no specific effect on the sodium channel (as was the case with AZA). However in combination, glutaric acid (1mM) and azaspiracid (50nM) inhibited the activity of the sodium channel by over 50%. Glutaric acid was subsequently detected in all shellfish employed in the study. For the first time a viable mechanism for how AZA manifests itself as a toxin is presented.

title: New insights into the causes of XXXX @entity2 due to consumption of azaspiracid contaminated shellfish.

answer: @entity0


abstract: UNASSIGNED: @entity9 -induced @entity11 , which raises several diagnostic and therapeutical challenges, is often overlooked. @entity8 can induce @entity6 , a harmful @entity5 which can precipitate @entity3 and cause @entity1 . We report the case of an elderly @entity0 who was diagnosed with tachyfibrillation secondary to @entity8 . Thyroid @entity12 was subsequently related both to previous @entity10 therapy (probably mixed form) and the recent use of iodinated contrast medium for computed tomography scan. Thyroid ultrasonography showed a @entity7 . After initial worsening, thyroid function improved slowly but progressively on high-dose thyreostatic therapy combined with @entity2 therapy; tachyfibrillation caused @entity3 and a @entity4 in the left atrium, and proved initially resistant to combined antiarrhythmic treatments. Progressive reduction in thyroid hormone levels, together with combined cardiologic therapies, controlled the heart rate, though @entity6 persisted; anticoagulant therapy resolved the @entity4 . Alterations in thyroid function are common in @entity10 -treated @entity0 , who therefore require regular hormonal checks. The different forms of @entity10 -induced @entity11 must be investigated, since they require different therapies, though mixed forms often occur. The superimposition of further @entity9 excess due to other causes may be catastrophic and cause severe cardiac problems in these @entity0 .

title: XXXX -induced @entity8 as combination of different etiologies: an overlooked entity in the elderly.

answer: @entity9


abstract: UNASSIGNED: @entity9 -induced @entity11 , which raises several diagnostic and therapeutical challenges, is often overlooked. @entity8 can induce @entity6 , a harmful @entity5 which can precipitate @entity3 and cause @entity1 . We report the case of an elderly @entity0 who was diagnosed with tachyfibrillation secondary to @entity8 . Thyroid @entity12 was subsequently related both to previous @entity10 therapy (probably mixed form) and the recent use of iodinated contrast medium for computed tomography scan. Thyroid ultrasonography showed a @entity7 . After initial worsening, thyroid function improved slowly but progressively on high-dose thyreostatic therapy combined with @entity2 therapy; tachyfibrillation caused @entity3 and a @entity4 in the left atrium, and proved initially resistant to combined antiarrhythmic treatments. Progressive reduction in thyroid hormone levels, together with combined cardiologic therapies, controlled the heart rate, though @entity6 persisted; anticoagulant therapy resolved the @entity4 . Alterations in thyroid function are common in @entity10 -treated @entity0 , who therefore require regular hormonal checks. The different forms of @entity10 -induced @entity11 must be investigated, since they require different therapies, though mixed forms often occur. The superimposition of further @entity9 excess due to other causes may be catastrophic and cause severe cardiac problems in these @entity0 .

title: @entity9 -induced XXXX as combination of different etiologies: an overlooked entity in the elderly.

answer: @entity8


abstract: BACKGROUND: Obesity is correlated with several comorbidities, including @entity1 . Its main complications are detectable by endoscopy: @entity4 and @entity2 . AIM: To correlate @entity4 and @entity3 with the degree of body mass index (BMI). METHOD: Was performed a retrospective analysis of 717 preoperative endoscopic reports of bariatric @entity0 . Fifty-six (8%) presented @entity3 , being 44 small, nine medium and five large. @entity4 was classified by Los Angeles classification. RESULTS: There was no correlation between the presence and dimension of @entity3 with BMI. One hundred thirty-four (18.7%) @entity0 presented @entity4 . Among them, 104 (14.5%) had @entity4 grade A; 25 (3.5%) grade B; and five (0.7%) grade C. When considering only the @entity0 with @entity4 , 77.6% had @entity4 grade A, 18.7% grade B and 3.7% grade C. Were identified only two @entity0 with @entity2 (0,28%). CONCLUSION: There was a positive correlation between the degree of @entity4 with increasing BMI.

title: ENDOSCOPIC CHANGES RELATED TO GASTROESOPHAGEAL REFLUX DISEASE: COMPARATIVE STUDY AMONG BARIATRIC SURGERY XXXX .

answer: @entity0


abstract: BACKGROUND: Subcutaneous @entity12 -like @entity8 represent a rare and difficult to diagnose entity of @entity8 . SPTL affects predominantly young adults and presents with multifocal subcutaneous nodules and frequently associated autoimmune features. The pathogenesis of SPTL is not completely understood. METHODS: The aim of this study was to unravel molecular pathways critical to the SPTL pathogenesis. Therefore, we analyzed 23 skin samples from 20 newly diagnosed SPTL @entity0 and relevant control samples of adipose and non-malignant @entity12 tissue by using gene expression microarray, quantitative PCR, and two-colour immunohistochemistry. RESULTS: Interestingly, @entity11 2,3-dioxygenase ( @entity14 ), an immunotolerance-inducing enzyme, was among the most highly overexpressed genes in all comparisons. The expression of @entity9 -specific cytokines, known to be associated with @entity1 (i.e. @entity6 , @entity2 , @entity5 , @entity3 , @entity4 , and @entity13 ), were also significantly increased. Confirmed using immunohistochemistry, the morphologically malignant lymphocytes expressed @entity2 and @entity5 . @entity14 expression was found both in some morphologically malignant lymphocytes rimming the adipocytes and in surrounding @entity10 (-) CD68(-) cells but not in @entity10 (+) dendritic cells in the microenvironment. The proportion of @entity7 + cells in SPTL exceeded that in the benign @entity12 samples. CONCLUSIONS: Our results indicate that the up regulation of the tolerogenic @entity14 together with the up regulation of @entity6 , @entity2 ligands, and @entity13 are features of SPTL lesions. We anticipate that the @entity6 -inducible @entity14 expression contributes to the formation of an immunosuppressive microenvironment, favorable for the malignant T cells. This study provides a relevant molecular basis for further studies exploring novel therapeutic means for subcutaneous @entity8 .

title: Molecular characterization of subcutaneous @entity12 -like XXXX reveals upregulation of immunosuppression- and autoimmunity-associated genes.

answer: @entity8


abstract: BACKGROUND: Subcutaneous @entity12 -like @entity8 represent a rare and difficult to diagnose entity of @entity8 . SPTL affects predominantly young adults and presents with multifocal subcutaneous nodules and frequently associated autoimmune features. The pathogenesis of SPTL is not completely understood. METHODS: The aim of this study was to unravel molecular pathways critical to the SPTL pathogenesis. Therefore, we analyzed 23 skin samples from 20 newly diagnosed SPTL @entity0 and relevant control samples of adipose and non-malignant @entity12 tissue by using gene expression microarray, quantitative PCR, and two-colour immunohistochemistry. RESULTS: Interestingly, @entity11 2,3-dioxygenase ( @entity14 ), an immunotolerance-inducing enzyme, was among the most highly overexpressed genes in all comparisons. The expression of @entity9 -specific cytokines, known to be associated with @entity1 (i.e. @entity6 , @entity2 , @entity5 , @entity3 , @entity4 , and @entity13 ), were also significantly increased. Confirmed using immunohistochemistry, the morphologically malignant lymphocytes expressed @entity2 and @entity5 . @entity14 expression was found both in some morphologically malignant lymphocytes rimming the adipocytes and in surrounding @entity10 (-) CD68(-) cells but not in @entity10 (+) dendritic cells in the microenvironment. The proportion of @entity7 + cells in SPTL exceeded that in the benign @entity12 samples. CONCLUSIONS: Our results indicate that the up regulation of the tolerogenic @entity14 together with the up regulation of @entity6 , @entity2 ligands, and @entity13 are features of SPTL lesions. We anticipate that the @entity6 -inducible @entity14 expression contributes to the formation of an immunosuppressive microenvironment, favorable for the malignant T cells. This study provides a relevant molecular basis for further studies exploring novel therapeutic means for subcutaneous @entity8 .

title: Molecular characterization of subcutaneous XXXX -like @entity8 reveals upregulation of immunosuppression- and autoimmunity-associated genes.

answer: @entity12


abstract: UNASSIGNED: We examined the effects of @entity9 in @entity2 subjected to @entity8 ( @entity8 ). @entity9 (50, 100, and 200   mg/kg, i.p.), was administered from the day of surgery for 14   days. Spinal cord levels of apoptotic factors and glia markers were quantified on days 3, 7, and 14 post- @entity8 . Oxidative stress markers were assessed on days 7 and 14. @entity8 @entity2 exhibited a marked mechanical @entity4 , @entity4 , and thermal @entity4 on days 3, 5, 7, 10, and 14 post- @entity8 . A significant increase in the levels of Iba (a marker of microglia activation) and @entity7 (a proapoptotic factor) was observed on day 3. Iba remained high on day 7. In contrast, there were no differences in glial fibrillary acidic protein contents between sham and @entity8 animals. @entity3 increased and reduced @entity6 decreased on day 14. @entity9 significantly attenuated behavioral changes associated with @entity1 . @entity7 decreased, while @entity5 was increased by @entity9 on day 3. @entity9 also reduced Iba protein on days 3 and 7. The results support evidence that microglial activation, apoptotic factors, and oxidative stress may have a pivotal role in the @entity0 pathogenesis. It is suggested that antinociceptive effects elicited by @entity9 might be through the inhibition of microglia activation, apoptotic pathways, and antioxidant properties. Copyright    2015 John Wiley _ Sons, Ltd.

title: The Effect of @entity9 in XXXX Induced by Chronic Constriction Injury in @entity2 .

answer: @entity0


abstract: UNASSIGNED: We examined the effects of @entity9 in @entity2 subjected to @entity8 ( @entity8 ). @entity9 (50, 100, and 200   mg/kg, i.p.), was administered from the day of surgery for 14   days. Spinal cord levels of apoptotic factors and glia markers were quantified on days 3, 7, and 14 post- @entity8 . Oxidative stress markers were assessed on days 7 and 14. @entity8 @entity2 exhibited a marked mechanical @entity4 , @entity4 , and thermal @entity4 on days 3, 5, 7, 10, and 14 post- @entity8 . A significant increase in the levels of Iba (a marker of microglia activation) and @entity7 (a proapoptotic factor) was observed on day 3. Iba remained high on day 7. In contrast, there were no differences in glial fibrillary acidic protein contents between sham and @entity8 animals. @entity3 increased and reduced @entity6 decreased on day 14. @entity9 significantly attenuated behavioral changes associated with @entity1 . @entity7 decreased, while @entity5 was increased by @entity9 on day 3. @entity9 also reduced Iba protein on days 3 and 7. The results support evidence that microglial activation, apoptotic factors, and oxidative stress may have a pivotal role in the @entity0 pathogenesis. It is suggested that antinociceptive effects elicited by @entity9 might be through the inhibition of microglia activation, apoptotic pathways, and antioxidant properties. Copyright    2015 John Wiley _ Sons, Ltd.

title: The Effect of XXXX in @entity0 Induced by Chronic Constriction Injury in @entity2 .

answer: @entity9


abstract: UNASSIGNED: We examined the effects of @entity9 in @entity2 subjected to @entity8 ( @entity8 ). @entity9 (50, 100, and 200   mg/kg, i.p.), was administered from the day of surgery for 14   days. Spinal cord levels of apoptotic factors and glia markers were quantified on days 3, 7, and 14 post- @entity8 . Oxidative stress markers were assessed on days 7 and 14. @entity8 @entity2 exhibited a marked mechanical @entity4 , @entity4 , and thermal @entity4 on days 3, 5, 7, 10, and 14 post- @entity8 . A significant increase in the levels of Iba (a marker of microglia activation) and @entity7 (a proapoptotic factor) was observed on day 3. Iba remained high on day 7. In contrast, there were no differences in glial fibrillary acidic protein contents between sham and @entity8 animals. @entity3 increased and reduced @entity6 decreased on day 14. @entity9 significantly attenuated behavioral changes associated with @entity1 . @entity7 decreased, while @entity5 was increased by @entity9 on day 3. @entity9 also reduced Iba protein on days 3 and 7. The results support evidence that microglial activation, apoptotic factors, and oxidative stress may have a pivotal role in the @entity0 pathogenesis. It is suggested that antinociceptive effects elicited by @entity9 might be through the inhibition of microglia activation, apoptotic pathways, and antioxidant properties. Copyright    2015 John Wiley _ Sons, Ltd.

title: The Effect of @entity9 in @entity0 Induced by Chronic Constriction Injury in XXXX .

answer: @entity2


abstract: @entity3 and @entity6 are critical to photoreceptor structure, function, and development. The transport of these nutrients between the pigment epithelium and @entity4 is mediated by interphotoreceptor retinoid-binding protein ( @entity9 ). @entity9 , a 133-kDa ( @entity0 ) glycolipoprotein, is the major protein component of the extracellular matrix separating these two cell layers. In amphibians and mammals, @entity9 consists of four homologous repeats of about 300 @entity5 which form two @entity3 and four @entity2 -binding sites. Here we show that @entity9 in teleosts is a simpler protein composed of only two repeats. Western blot analysis shows that @entity7 @entity9 is half the size (70 kDa) of @entity9 in higher vertebrates. Metabolic labeling studies employing @entity8 taken together with in situ hybridization studies and the presence of a signal peptide show that @entity7 @entity9 is secreted by the cone photoreceptors. The translated @entity1 sequence has a calculated molecular weight of 66.7 kDa. The primary structure consists of only two homologous repeats with a similarity score of 52.5%. The last repeats of @entity0 and @entity7 IRBPs are 69.1% similar with hydrophobic regions being the most similar. These data suggest that two repeats were lost during the evolution of the ray-finned fish (Actinopterygii), or that the @entity9 gene duplicated between the emergence of bony fish (Osteichthyes) and amphibians. Acquisition of a multirepeat structure may reflect evolutionary pressure to efficiently transport higher levels of hydrophobic molecules within a finite space. Quadruplication of an ancestral @entity9 gene may have been an important event in the evolution of photo-receptors in higher vertebrates.

title: XXXX cones secrete a two-repeat interphotoreceptor retinoid-binding protein.

answer: @entity7


abstract: PURPOSE: The impact of prostatectomy on quality of life was assessed in @entity0 with @entity3 ( @entity3 ) who were classified according to the expected benefit from surgical intervention. The relative impact of the 2 surgical techniques (open versus closed) on short-term quality of life was compared. MATERIALS AND METHODS: An observational study was done on 545 consecutive @entity0 with @entity3 undergoing prostatectomy at 3 medical centers in Israel between 1991 and 1992. Repeated structured interviews preoperatively, and at 4 and 12 months postoperatively were performed, including 6 quality of life questionnaires evaluating @entity3 specific (symptom severity and symptom effect) and generic (activity, independence, mental health and health perception) parameters. In addition, the interviews consisted of socio-demographic data elements. Clinical details regarding severity of @entity4 and co-morbidity were obtained from the medical charts. RESULTS: We found a correlation between postoperative change in symptom effect and in generic quality of life measures (r-0.11 to 0.20, p < 0.04). The postoperative decrease in the mean symptom effect score was 56% and 52% for severe and moderate preoperative levels, respectively. There was no decrease in the mean symptom effect score for the mild preoperative level (18% of these @entity0 had @entity2 ). A secondary operation, and the @entity1 and poor activity level were risk factors for lack of improvement in @entity0 with moderate preoperative symptom effects. We found that the impact of open prostatectomy on quality of life was similar to that of the closed technique after adjustment for @entity0 attributes, except for those with an indwelling urinary catheter in whom an open operation was advantageous. CONCLUSIONS: In @entity0 with @entity3 and mild symptom effects, and in subgroups of @entity0 with moderate symptom effects surgery should not be recommended. Based on short-term measures of quality of life there is no justification for a preference between open and closed operations.

title: Factors affecting change in quality of life after prostatectomy for XXXX : the impact of surgical techniques.

answer: @entity3