abstract: UNASSIGNED: Background:Systemic inflammatory response (SIR) is important in the relationship between the @entity1 , the host, and outcome in @entity1 @entity0 . However, limited data exist regarding the prognostic significance of SIR in @entity2 . We investigate the utility of pretreatment SIR in @entity0 with @entity3 undergoing radical cystectomy.Methods:The study cohort consisted of 419 @entity0 with a median follow-up of 37.7 months. The SIRs used for each described prognostic nomogram are consistent with previously published data: @entity6 , albumin, white cell count, neutrophil count, lymphocyte count, and platelet count. Primary end point was disease-specific survival (DSS) and @entity5 ( @entity5 ) after surgery. Cox regression models were used to determine the time to disease-specific and overall mortality. Multivariate regression coefficients of the predictors were used to develop nomograms for predicting 5-year DSS and @entity5 probability.Results:Multivariate Cox regression analyses revealed that albumin, lymphocyte count, and platelet count were significantly associated with a significantly increased risk for @entity4 from @entity2 . The nomograms including each index were developed to predict the probability of 5-year DSS and @entity5 after radical cystectomy. The C statistics were 77.8% and 77.3%, respectively, and exceeded the 2002 AJCC (72.0% and 70.3%, respectively). In the decision curve analyses, the nomograms including SIR demonstrated higher net benefit gains compared with the models without SIR.Conclusions:Cellular components of SIR have better prognostic values compared with acute-phase protein in @entity0 undergoing radical cystectomy for @entity2 .

title: The prognostic value of pretreatment of systemic inflammatory responses in @entity0 with XXXX undergoing radical cystectomy.

answer: @entity3


abstract: UNASSIGNED: Background:Systemic inflammatory response (SIR) is important in the relationship between the @entity1 , the host, and outcome in @entity1 @entity0 . However, limited data exist regarding the prognostic significance of SIR in @entity2 . We investigate the utility of pretreatment SIR in @entity0 with @entity3 undergoing radical cystectomy.Methods:The study cohort consisted of 419 @entity0 with a median follow-up of 37.7 months. The SIRs used for each described prognostic nomogram are consistent with previously published data: @entity6 , albumin, white cell count, neutrophil count, lymphocyte count, and platelet count. Primary end point was disease-specific survival (DSS) and @entity5 ( @entity5 ) after surgery. Cox regression models were used to determine the time to disease-specific and overall mortality. Multivariate regression coefficients of the predictors were used to develop nomograms for predicting 5-year DSS and @entity5 probability.Results:Multivariate Cox regression analyses revealed that albumin, lymphocyte count, and platelet count were significantly associated with a significantly increased risk for @entity4 from @entity2 . The nomograms including each index were developed to predict the probability of 5-year DSS and @entity5 after radical cystectomy. The C statistics were 77.8% and 77.3%, respectively, and exceeded the 2002 AJCC (72.0% and 70.3%, respectively). In the decision curve analyses, the nomograms including SIR demonstrated higher net benefit gains compared with the models without SIR.Conclusions:Cellular components of SIR have better prognostic values compared with acute-phase protein in @entity0 undergoing radical cystectomy for @entity2 .

title: The prognostic value of pretreatment of systemic inflammatory responses in XXXX with @entity3 undergoing radical cystectomy.

answer: @entity0


abstract: PURPOSE: Preclinical imaging of @entity2 ( @entity2 ) can elucidate molecular mechanisms underlying @entity1 . We compared the repeatability and variability of two methods, first-pass MRI and arterial spin labeling (ASL), for imaging @entity2 in @entity0 . METHODS: Quantitative perfusion MRI in @entity0 was performed using both methods at rest, with a vasodilator, and one day after @entity3 . Image quality (score of 1-5; 5 best), between-session coefficient of variability (CVbs ), intra-user coefficient of variability (CVintra-user ), and inter-user coefficient of variability (CVinter-user ) were assessed. Acquisition time was 1-2 min for first-pass MRI and approximately 40 min for ASL. RESULTS: Image quality was higher for ASL (3.94        0.09 versus 2.88        0.10; P   <   0.05). Infarct zone CVbs was lower with first-pass (17        3% versus 46        9%; P   <   0.05). The stress perfusion CVintra-user was lower for ASL (3        1% versus 14        3%; P   <   0.05). The stress perfusion CVinter-user was lower for ASL (4        1% versus 17        4%; P   <   0.05). CONCLUSION: For low @entity2 conditions such as @entity4 , first-pass MRI is preferred due to better repeatability and variability. At high @entity2 such as at vasodilation, ASL may be more suitable due to superior image quality and lower user variability. First-pass MRI has a substantial speed advantage. Magn Reson Med, 2015.    2015 Wiley Periodicals, Inc.

title: Repeatability and variability of myocardial perfusion imaging techniques in XXXX : Comparison of arterial spin labeling and first-pass contrast-enhanced MRI.

answer: @entity0


abstract: @entity9 is a focal @entity8 ; it is characterized by an accelerated rate of bone remodeling, with profound changes in the bone structure, making it fragile. This condition affects approximately 2% to 5% of the population older than 40. The main clinical manifestations of @entity9 are @entity2 and @entity1 , although the majority of @entity0 are asymptomatic. @entity11 is a @entity7 with a prevalence of about 0,1%. It is characterized by the presence of @entity5 , @entity10 and/or dactylitis associated with a familiar or personal history of @entity6 . Several clinical patterns of joint involvement in @entity11 have been identified, namely, the polyarticular pattern, similar to @entity4 . @entity5 precedes @entity3 in approximately 13 to 17 % of the cases. The authors report a clinical case of a 60 years old @entity0 with @entity5 and dactylitis who was diagnosed with @entity11 and @entity9 . The concomitance of the two entities, in the same individual, with so different pathogenesis and clinical features, have never been described on literature. Because of the complexity on the clinical and imaging evaluation as the result of the coexistence of both pathologies, the authors consider relevant to publish this singular case.

title: [ XXXX concomitant with Paget's Disease - A case report].

answer: @entity11


abstract: OBJECTIVE: To describe successful termination of an outbreak of @entity1 -resistant @entity2 (VREfm) colonization within a neonatal service. SETTING: Multisite neonatal intensive care unit and special care nurseries within a single health care service. @entity0 : Forty-four cases of VREfm-colonized neonatal inpatients-including 2 clinical isolates (eye swab and catheter-urine specimen) and 42 screening isolates. INTERVENTIONS: Active surveillance cultures, @entity0 isolation, contact precautions, enhanced environment cleaning, and staff and parent education. Whole genome sequencing and multilocus sequence typing were used to characterize the outbreak and refine infection control procedures. RESULTS: Peak prevalence of VREfm colonization across all sites was 31% upon discovery of the outbreak. Subsequent to the intervention, transmission was halted within 8 weeks and no further isolates of the outbreak strain have been detected as of 12  months following outbreak cessation. Environmental swabs revealed VREfm colonization of baby-weighing scales, a baby bath, and a pharmacy refrigerator within the neonatal intensive care unit. All isolates were of a single multilocus sequence type (sequence type 796) and highly clonal at the core genome level. CONCLUSIONS: Bundled infection control interventions were effective in rapidly terminating a clonal outbreak of sequence type 796 VREfm colonization within a neonatal inpatient service. Strain-typing and active surveillance cultures were critical in guiding the management of this outbreak. The closed environment of a neonatal unit likely facilitated eradication of the @entity0 and environment reservoirs of VREfm colonization.

title: Outbreak of vanB XXXX -resistant @entity2 colonization in a neonatal service.

answer: @entity1


abstract: OBJECTIVE: To describe successful termination of an outbreak of @entity1 -resistant @entity2 (VREfm) colonization within a neonatal service. SETTING: Multisite neonatal intensive care unit and special care nurseries within a single health care service. @entity0 : Forty-four cases of VREfm-colonized neonatal inpatients-including 2 clinical isolates (eye swab and catheter-urine specimen) and 42 screening isolates. INTERVENTIONS: Active surveillance cultures, @entity0 isolation, contact precautions, enhanced environment cleaning, and staff and parent education. Whole genome sequencing and multilocus sequence typing were used to characterize the outbreak and refine infection control procedures. RESULTS: Peak prevalence of VREfm colonization across all sites was 31% upon discovery of the outbreak. Subsequent to the intervention, transmission was halted within 8 weeks and no further isolates of the outbreak strain have been detected as of 12  months following outbreak cessation. Environmental swabs revealed VREfm colonization of baby-weighing scales, a baby bath, and a pharmacy refrigerator within the neonatal intensive care unit. All isolates were of a single multilocus sequence type (sequence type 796) and highly clonal at the core genome level. CONCLUSIONS: Bundled infection control interventions were effective in rapidly terminating a clonal outbreak of sequence type 796 VREfm colonization within a neonatal inpatient service. Strain-typing and active surveillance cultures were critical in guiding the management of this outbreak. The closed environment of a neonatal unit likely facilitated eradication of the @entity0 and environment reservoirs of VREfm colonization.

title: Outbreak of vanB @entity1 -resistant XXXX colonization in a neonatal service.

answer: @entity2


abstract: OBJECTIVE: To study the association of renal function with renal perfusion and renal parenchymal structure (T1 relaxation) in @entity0 with @entity6 ( @entity6 ). METHODS: After IRB approval, 40 @entity0 were enrolled according to @entity6 and renal function status [10 healthy volunteers   <   40  years; 10 healthy age-matched volunteers; 10 @entity6 @entity0 @entity5   >   60  ml/min/1.73  m(2); 10 @entity6 @entity0 @entity5   <   60  ml/min/1.73  m(2)] and assessed by MRI. To be eligible for enrolment all @entity6 @entity0 with @entity2 ( @entity2 ) needed to be diagnosed as having chronic @entity7 based on current guidelines. @entity0 with primary @entity2 were excluded. RESULTS: Renal cortical perfusion correlated with @entity5 values (r   =   0.52;p   <   0.01) and was similar between @entity6 @entity0 with and without @entity2 (p   =   0.27). T1 relaxation correlated negatively with @entity5 values (r   =   -0.41;p   >   0.01) and was higher in @entity6 @entity0 compared to volunteers (1121        102  ms vs. 1054        65  ms;p   =   0.03). T1 relaxation was selectively prolonged in @entity6 @entity0 with @entity2 (1169  ms        100 vs. @entity6 without @entity2 1067  ms        79;p   =   0.047). In linear regression analyses @entity4 (p   =   0.01), @entity3 (p   =   0.04), and @entity1 (p   <   0.01) were associated with T1 relaxation. CONCLUSION: @entity2 in @entity6 is not primarily mediated by decreased renal perfusion. Instead, chronic reno- @entity2 , as indicated by prolonged T1 relaxation, appears to underly chronic @entity7 . KEY POINTS:     The pathophysiology underlying chronic @entity7 is not completely understood.     Chronic @entity7 is independent of cardiac output or renal perfusion.     Renal T 1 relaxation appears to be prolonged in @entity6 with @entity2 .     Renal T 1 relaxation is associated with classic cardiovascular risk factors.     Association of renal T 1 relaxation with @entity2 should be validated further.

title: The pathophysiology of the chronic XXXX : a magnetic resonance imaging study.

answer: @entity7


abstract: OBJECTIVE: To utilise an exposed/unexposed cohort strategy for mortality and @entity1 analyses across unselected and complete cohorts of @entity0 with @entity5 ( @entity5 ) resident in south-east Norway (denominator population 2.6 million), between 2003 and 2012. METHOD: @entity5 cases were identified by comprehensive searches through @entity0 administrative databases followed by manual chart review. @entity8 ( @entity8 ) and @entity7 ( @entity7 ) cases were classified by the Peter and Bohan and/or Targoff diagnostic criteria and @entity6 ( @entity6 ) by the European NeuroMuscular Centre (ENMC) criteria from 1997 and/or 2011. Every @entity0 was matched for sex, age and residential area with 15 unexposed/non- @entity5 individuals drawn from the national population registry. RESULTS: Total mortality in the @entity5 cohort was 27% (87/326). Standardized mortality rate (SMR) was higher in @entity7 (2.6) than @entity8 (2.4) and @entity6 (1.7). @entity5 -related causes of @entity3 were frequent (64%) and included @entity1 (all @entity5 subsets), aspiration ( @entity6 ), @entity4 ( @entity8 / @entity7 ) and infections ( @entity8 / @entity7 ). Multivariate analyses identified age at diagnosis ( @entity8 and @entity6 ), positive anti-SSA ( @entity8 ), @entity1 ( @entity7 ), and DLCO < 60% ( @entity7 ) as independent mortality risk factors. @entity1 risk was increased in @entity7 (standard incidence rate 2.0) and @entity8 (SIR = 1.3), but not in @entity6 (SIR = 0.9). @entity2 was more prevalent in @entity7 than in the general population (8.3% vs 1.1%). CONCLUSION: Our results suggest that mortality rates and @entity1 risk remain elevated in @entity7 , and to a lesser degree also in @entity8 . Mortality rate was also increased in @entity6 , but some @entity3 appeared to be due to potentially preventable causes.

title: Survival and @entity1 risk in an unselected and complete Norwegian XXXX cohort.

answer: @entity5


abstract: OBJECTIVE: To utilise an exposed/unexposed cohort strategy for mortality and @entity1 analyses across unselected and complete cohorts of @entity0 with @entity5 ( @entity5 ) resident in south-east Norway (denominator population 2.6 million), between 2003 and 2012. METHOD: @entity5 cases were identified by comprehensive searches through @entity0 administrative databases followed by manual chart review. @entity8 ( @entity8 ) and @entity7 ( @entity7 ) cases were classified by the Peter and Bohan and/or Targoff diagnostic criteria and @entity6 ( @entity6 ) by the European NeuroMuscular Centre (ENMC) criteria from 1997 and/or 2011. Every @entity0 was matched for sex, age and residential area with 15 unexposed/non- @entity5 individuals drawn from the national population registry. RESULTS: Total mortality in the @entity5 cohort was 27% (87/326). Standardized mortality rate (SMR) was higher in @entity7 (2.6) than @entity8 (2.4) and @entity6 (1.7). @entity5 -related causes of @entity3 were frequent (64%) and included @entity1 (all @entity5 subsets), aspiration ( @entity6 ), @entity4 ( @entity8 / @entity7 ) and infections ( @entity8 / @entity7 ). Multivariate analyses identified age at diagnosis ( @entity8 and @entity6 ), positive anti-SSA ( @entity8 ), @entity1 ( @entity7 ), and DLCO < 60% ( @entity7 ) as independent mortality risk factors. @entity1 risk was increased in @entity7 (standard incidence rate 2.0) and @entity8 (SIR = 1.3), but not in @entity6 (SIR = 0.9). @entity2 was more prevalent in @entity7 than in the general population (8.3% vs 1.1%). CONCLUSION: Our results suggest that mortality rates and @entity1 risk remain elevated in @entity7 , and to a lesser degree also in @entity8 . Mortality rate was also increased in @entity6 , but some @entity3 appeared to be due to potentially preventable causes.

title: Survival and XXXX risk in an unselected and complete Norwegian @entity5 cohort.

answer: @entity1


abstract: PURPOSE: This study was designed to compare quality of life in a sample of Italian @entity0 affected by @entity3 -sensitive recurrent @entity1 and submitted to chemotherapy alone or secondary cytoreductive surgery plus chemotherapy through validated questionnaires. METHODS: From January 2007 to December 2012, consecutive @entity0 with suspicious recurrence of @entity1 , referred to the Division of Gynecologic Oncology at the University Campus Bio-Medico of Rome, were assessed for this prospective, case-control study. After a diagnostic laparoscopy, surgical resectable @entity0 were enrolled in group A (surgery plus chemotherapy). @entity0 not suitable for optimal debulking surgery and all @entity0 who refused surgery were enrolled in group B (chemotherapy alone). At beginning of treatment, after the third and sixth cycle of chemotherapy, all eligible @entity0 were asked to fill in QLQ-C30 (version 3.0) and EORTC QLQ-OV28 questionnaires. RESULTS: Group A included 38 @entity0 and underwent @entity5 followed by chemotherapy; group B included 16 @entity0 that were submitted to chemotherapy alone. Quality-of-life scores of both questionnaires were comparable between groups, with the exception of @entity4 and @entity2 , which resulted significantly worsened in Group A at 3  months. This difference was no longer present at 6  months. Median overall survival was 72  % for Group A and 56  % in Group B at median follow-up of 35  months for Group A and 32  months for Group B. CONCLUSIONS: Both surgery followed by chemotherapy and chemotherapy alone seem to have a negligible impact on QOL. @entity5 plus chemotherapy seems to be an effective and tolerable therapeutic option in @entity3 -sensitive recurrences.

title: Quality of Life in @entity3 -Sensitive Recurrent XXXX : Chemotherapy Versus Surgery Plus Chemotherapy.

answer: @entity1


abstract: PURPOSE: This study was designed to compare quality of life in a sample of Italian @entity0 affected by @entity3 -sensitive recurrent @entity1 and submitted to chemotherapy alone or secondary cytoreductive surgery plus chemotherapy through validated questionnaires. METHODS: From January 2007 to December 2012, consecutive @entity0 with suspicious recurrence of @entity1 , referred to the Division of Gynecologic Oncology at the University Campus Bio-Medico of Rome, were assessed for this prospective, case-control study. After a diagnostic laparoscopy, surgical resectable @entity0 were enrolled in group A (surgery plus chemotherapy). @entity0 not suitable for optimal debulking surgery and all @entity0 who refused surgery were enrolled in group B (chemotherapy alone). At beginning of treatment, after the third and sixth cycle of chemotherapy, all eligible @entity0 were asked to fill in QLQ-C30 (version 3.0) and EORTC QLQ-OV28 questionnaires. RESULTS: Group A included 38 @entity0 and underwent @entity5 followed by chemotherapy; group B included 16 @entity0 that were submitted to chemotherapy alone. Quality-of-life scores of both questionnaires were comparable between groups, with the exception of @entity4 and @entity2 , which resulted significantly worsened in Group A at 3  months. This difference was no longer present at 6  months. Median overall survival was 72  % for Group A and 56  % in Group B at median follow-up of 35  months for Group A and 32  months for Group B. CONCLUSIONS: Both surgery followed by chemotherapy and chemotherapy alone seem to have a negligible impact on QOL. @entity5 plus chemotherapy seems to be an effective and tolerable therapeutic option in @entity3 -sensitive recurrences.

title: Quality of Life in XXXX -Sensitive Recurrent @entity1 : Chemotherapy Versus Surgery Plus Chemotherapy.

answer: @entity3


abstract: UNASSIGNED: @entity5 (LA) accumulates under inflammatory conditions, e.g. in wounds or @entity1 , and influences local immune cell functions. We previously noted inhibitory effects of LA on glycolysis and @entity2 secretion of @entity0 @entity3 -stimulated monocytes. Here, we globally analyze the influence of LA on gene expression during monocyte activation. To separate LA-specific from @entity5 - or pH-effects, monocytes were treated for one or four hours with @entity3 in the presence of physiological concentrations of LA, @entity10 (NaL) or acidic pH. Analyses of global gene expression profiles revealed striking effects of LA during the early stimulation phase. Up-regulation of most @entity3 -induced genes was significantly delayed in the presence of LA, while this inhibitory effect was attenuated in acidified samples and not detected after incubation with NaL. LA targets included genes encoding for important monocyte effector proteins like cytokines (e.g. @entity2 and @entity8 ) or chemokines (e.g. @entity6 and @entity9 ). LA effects were validated for several targets by quantitative RT-PCR and/or ELISA. Further analysis of @entity3 -signaling pathways revealed that LA delayed the phosphorylation of protein kinase B ( @entity4 ) as well as the degradation of @entity7 . Consistently, the @entity3 -induced nuclear accumulation of NFkB was also diminished in response to LA. These results indicate that the broad effect of LA on gene expression and function of @entity0 monocytes is at least partially caused by its interference with immediate signal transduction events after activation. This mechanism might contribute to monocyte suppression in the @entity1 environment.

title: Lactic acid delays the inflammatory response of XXXX monocytes.

answer: @entity0


abstract: UNASSIGNED: Although joint-preserving surgery for intermediate @entity2 has been reported to be effective, failures of supramalleolar osteotomy and plafond-plasty can occur because of persistent @entity1 of the distal tibia and incongruent ankle mortise. We introduce a novel opening wedge distal tibial osteotomy procedure (mortise-plasty) with rigid plate fixation combined with synthetic bone wedges. We performed 27 mortise-plasties in 25 @entity0 with @entity2 and instability. Six males (24%) and 19 females (76%), with a mean age of 63 (range 28 to 79) years, were followed up for a mean of 27.3 (range 14 to 45) months. The mean preoperative visual analog scale score, American Orthopaedic Foot and Ankle Society score, and Takakura ankle scale score were 7.4 (range 5.4 to 10), 58.7 (range 18 to 84), and 55.9 (range 29 to 88), respectively. These scores improved significantly to 2.1 (range 0 to 6.5), 89.3 (range 67 to 100), and 84.7 (range 55 to 100) postoperatively (p  <  .001). The mean preoperative tibial-anterior surface angle and talar tilt angle were 84.9   (range 78   to 90  ) and 8.3   (range 3   to 21  ), respectively. At the most recent follow-up visit, the corresponding values were 95.0   (range 82   to 99  ) and 1.8   (range 0   to 8  ), respectively (p  <  .001). Computed tomography scans indicated that the ankle mortise narrowed by approximately 1.8  mm and the tibial plafond was lowered after osteotomy. No @entity0 underwent lateral ligament reconstruction, ankle joint replacement, or arthrodesis. Mortise-plasty osteotomy corrects the intra-articular and extra-articular deformities simultaneously and provides good clinical and radiographic outcomes for @entity0 with @entity2 and instability.

title: Treatment of XXXX and Instability With a Novel Mortise-Plasty Osteotomy Procedure.

answer: @entity2


abstract: Cases of @entity5 caused by anaerobic microorganisms and occurring during a four year period in a non-selected @entity0 group in a Spanish general hospital were analysed retrospectively. Microbiological data was collected on 212 @entity0 and clinical data on 103 @entity0 . Cases of anaerobic @entity5 represented 8.6% of the total number of cases of @entity5 . Of the 232 anaerobic microorganisms causing @entity5 , gram-negative bacilli were responsible in 113 cases (48.7%), gram-positive bacilli in 92 cases (39.6%), gram-positive cocci in 25 cases (10.7%), and Veillonella @entity6 . in two cases (0.8%). The most important clinical features were @entity1 (64%), @entity4 (56%), @entity3 (22%) and metastatic abscesses (21%). @entity0 with anaerobic @entity5 were hospitalized for an average of 51.7 days. The overall mortality was 32% and factors associated with poor prognosis were severe underlying disease, nosocomial acquisition, presence of shock, presence of metastatic foci of @entity2 , and absence of adequate surgical drainage. The mortality rate of @entity0 who received adequate antimicrobial therapy was 30% and that of @entity0 who received inadequate treatment or none was 29%. It is concluded that anaerobic @entity5 has a significant rate of morbidity and mortality and that underlying disease and surgical debridement and/or drainage have greater prognostic significance than the use of antimicrobial agents.

title: Retrospective analysis of two hundred and twelve cases of XXXX due to anaerobic microorganisms.

answer: @entity5


abstract: In the search for novel potent fungi-derived bioactive compounds for bioinsecticide applications, crude @entity1 culture filtrate extracts from 110 mangrove fungal endophytes were screened for their @entity0 . @entity0 tests of all extracts against brine shrimp (Artemia salina) larvae were performed. The extracts with the highest @entity0 were further examined for insecticidal activity against Spodoptera litura larvae and acetylcholinesterase (AChE) inhibition activity. The results showed that the extracts of five isolates exhibited the highest @entity0 to brine shrimp at 50% lethal concentration (LC50) values of 7.45 to 10.24 ppm. These five fungal isolates that obtained from Rhizophora mucronata were identified based on sequence data analysis of the internal transcribed spacer region of rDNA as @entity3 BPPTCC 6036), @entity4 (strains BPPTCC 6035 and BPPTCC 6038), A. tamarii (strain BPPTCC 6037), and A. versicolor (strain BPPTCC 6039). The mean percentage of S. litura larval mortality following topical application of the five extracts ranged from 16.7% to 43.3%. In the AChE inhibition assay, the inhibition rates of the five extracts ranged from 40.7% to 48.9%, while @entity2 (positive control) had an inhibition rate of 96.8%, at a concentration of 100 ppm. The extracts used were crude extracts, so their potential as sources of AChE inhibition compounds makes them likely candidates as neurotoxins. The high-performance liquid chromatography profiles of the five extracts differed, indicating variations in their chemical constituents. This study highlights the potential of culture filtrate @entity1 extracts of mangrove fungal endophytes as a source of new potential bioactive compounds for bioinsecticide applications.

title: Insecticidal Activity of XXXX Extracts from Culture Filtrates of Mangrove Fungal Endophytes.

answer: @entity1


abstract: @entity3 ( @entity3 ) is an acute @entity2 that causes morbidity and mortality in critically ill @entity0 . However, there are many instances where @entity3 resolves spontaneously through endogenous pathways that help to control @entity2 . Previous studies have implicated the extracellular signaling molecule @entity5 and signaling events through the A2B @entity5 receptor in lung protection. In this context, we hypothesized that tissue-specific expression of the A2B @entity5 receptor is responsible for the previously described attenuation of @entity3 . To address this hypothesis, we exposed @entity1 with tissue-specific deletion of @entity8 to @entity3 , utilizing a two-hit model where intratracheal LPS treatment is followed by injurious mechanical ventilation. Interestingly, a head-to-head comparison of @entity1 with deletion of @entity8 in the myeloid lineage ( @entity8 (loxP/loxP) @entity10 Cre(+)), endothelial cells ( @entity8 (loxP/loxP) @entity7 Cre(+)), or alveolar epithelial cells ( @entity8 (loxP/loxP) SPC Cre(+)) revealed a selective increase in disease susceptibility in @entity8 (loxP/loxP) SPC Cre(+) @entity1 . More detailed analysis of @entity8 (loxP/loxP) SPC Cre(+) @entity1 confirmed @entity2 and attenuated alveolar fluid clearance. To directly deliver an A2B @entity5 receptor-specific agonist to alveolar epithelial cells, we subsequently performed studies with inhaled @entity9 . Indeed, aerosolized @entity9 treatment was associated with @entity6 , improved histologic @entity4 , and dampened @entity2 . Collectively, these findings suggest that alveolar epithelial A2B @entity5 receptor signaling contributes to lung protection, and they implicate inhaled A2B @entity5 receptor agonists in @entity3 treatment.

title: Alveolar Epithelial A2B @entity5 Receptors in Pulmonary Protection during Acute XXXX .

answer: @entity4


abstract: @entity3 ( @entity3 ) is an acute @entity2 that causes morbidity and mortality in critically ill @entity0 . However, there are many instances where @entity3 resolves spontaneously through endogenous pathways that help to control @entity2 . Previous studies have implicated the extracellular signaling molecule @entity5 and signaling events through the A2B @entity5 receptor in lung protection. In this context, we hypothesized that tissue-specific expression of the A2B @entity5 receptor is responsible for the previously described attenuation of @entity3 . To address this hypothesis, we exposed @entity1 with tissue-specific deletion of @entity8 to @entity3 , utilizing a two-hit model where intratracheal LPS treatment is followed by injurious mechanical ventilation. Interestingly, a head-to-head comparison of @entity1 with deletion of @entity8 in the myeloid lineage ( @entity8 (loxP/loxP) @entity10 Cre(+)), endothelial cells ( @entity8 (loxP/loxP) @entity7 Cre(+)), or alveolar epithelial cells ( @entity8 (loxP/loxP) SPC Cre(+)) revealed a selective increase in disease susceptibility in @entity8 (loxP/loxP) SPC Cre(+) @entity1 . More detailed analysis of @entity8 (loxP/loxP) SPC Cre(+) @entity1 confirmed @entity2 and attenuated alveolar fluid clearance. To directly deliver an A2B @entity5 receptor-specific agonist to alveolar epithelial cells, we subsequently performed studies with inhaled @entity9 . Indeed, aerosolized @entity9 treatment was associated with @entity6 , improved histologic @entity4 , and dampened @entity2 . Collectively, these findings suggest that alveolar epithelial A2B @entity5 receptor signaling contributes to lung protection, and they implicate inhaled A2B @entity5 receptor agonists in @entity3 treatment.

title: Alveolar Epithelial A2B XXXX Receptors in Pulmonary Protection during Acute @entity4 .

answer: @entity5


abstract: OBJECTIVE: @entity6 ( @entity6 ) has been closely associated with @entity1 . @entity3 has also been shown to be disproportionally prevalent among @entity1 @entity0 . However, there is still a paucity of studies on the relationship between @entity3 and @entity6 in @entity1 @entity0 . This study examined the difference in @entity2 and @entity3 between @entity1 and @entity1 -related @entity6 . METHODS: A total of 88 @entity1 @entity0 treated in our department were selected for analysis. They were divided into @entity1 (OB n=30) and @entity1 with acanthosis nigricans ( @entity6 n=58). A control (CON) group included 56 normal weight healthy volunteers. The self-administrated Beck @entity3 Inventory-II questionnaire was used. General characteristics and clinical data were collected for analysis. RESULTS: The frequency of @entity3 was recorded as 67.2% in the @entity6 group, 43.4% in the OB group, and 3.6% in the CON group (P <0.001). The severity of @entity3 in the @entity6 group was significantly higher than in the OB group and CON group (P <0.001). @entity0 with moderate @entity3 had higher levels of inflammatory markers than those with mild symptoms @entity3 . Free @entity5 (FFA) and @entity4 (UA) level in the @entity6 group were significantly increased compared with the OB group (P=0.010, P=0.020). Discrimination was associated with @entity3 (P <0.001). CONCLUSION: @entity1 @entity0 had a higher risk of @entity3 , which were even higher in @entity0 with @entity6 . @entity6 is associated with more @entity3 status. Psychological intervention should be started early to prevent further physical and pathological @entity1 @entity0 , especially @entity1 @entity0 with @entity6 .

title: Evaluation of XXXX in @entity1 @entity0 with or without acanthosis nigricans.

answer: @entity3


abstract: OBJECTIVE: @entity6 ( @entity6 ) has been closely associated with @entity1 . @entity3 has also been shown to be disproportionally prevalent among @entity1 @entity0 . However, there is still a paucity of studies on the relationship between @entity3 and @entity6 in @entity1 @entity0 . This study examined the difference in @entity2 and @entity3 between @entity1 and @entity1 -related @entity6 . METHODS: A total of 88 @entity1 @entity0 treated in our department were selected for analysis. They were divided into @entity1 (OB n=30) and @entity1 with acanthosis nigricans ( @entity6 n=58). A control (CON) group included 56 normal weight healthy volunteers. The self-administrated Beck @entity3 Inventory-II questionnaire was used. General characteristics and clinical data were collected for analysis. RESULTS: The frequency of @entity3 was recorded as 67.2% in the @entity6 group, 43.4% in the OB group, and 3.6% in the CON group (P <0.001). The severity of @entity3 in the @entity6 group was significantly higher than in the OB group and CON group (P <0.001). @entity0 with moderate @entity3 had higher levels of inflammatory markers than those with mild symptoms @entity3 . Free @entity5 (FFA) and @entity4 (UA) level in the @entity6 group were significantly increased compared with the OB group (P=0.010, P=0.020). Discrimination was associated with @entity3 (P <0.001). CONCLUSION: @entity1 @entity0 had a higher risk of @entity3 , which were even higher in @entity0 with @entity6 . @entity6 is associated with more @entity3 status. Psychological intervention should be started early to prevent further physical and pathological @entity1 @entity0 , especially @entity1 @entity0 with @entity6 .

title: Evaluation of @entity3 in XXXX @entity0 with or without acanthosis nigricans.

answer: @entity1


abstract: OBJECTIVE: @entity6 ( @entity6 ) has been closely associated with @entity1 . @entity3 has also been shown to be disproportionally prevalent among @entity1 @entity0 . However, there is still a paucity of studies on the relationship between @entity3 and @entity6 in @entity1 @entity0 . This study examined the difference in @entity2 and @entity3 between @entity1 and @entity1 -related @entity6 . METHODS: A total of 88 @entity1 @entity0 treated in our department were selected for analysis. They were divided into @entity1 (OB n=30) and @entity1 with acanthosis nigricans ( @entity6 n=58). A control (CON) group included 56 normal weight healthy volunteers. The self-administrated Beck @entity3 Inventory-II questionnaire was used. General characteristics and clinical data were collected for analysis. RESULTS: The frequency of @entity3 was recorded as 67.2% in the @entity6 group, 43.4% in the OB group, and 3.6% in the CON group (P <0.001). The severity of @entity3 in the @entity6 group was significantly higher than in the OB group and CON group (P <0.001). @entity0 with moderate @entity3 had higher levels of inflammatory markers than those with mild symptoms @entity3 . Free @entity5 (FFA) and @entity4 (UA) level in the @entity6 group were significantly increased compared with the OB group (P=0.010, P=0.020). Discrimination was associated with @entity3 (P <0.001). CONCLUSION: @entity1 @entity0 had a higher risk of @entity3 , which were even higher in @entity0 with @entity6 . @entity6 is associated with more @entity3 status. Psychological intervention should be started early to prevent further physical and pathological @entity1 @entity0 , especially @entity1 @entity0 with @entity6 .

title: Evaluation of @entity3 in @entity1 XXXX with or without acanthosis nigricans.

answer: @entity0


abstract: AIM: To investigate the clinical and social correlates of a lifetime history of crime victimization among first-episode @entity2 @entity0 at entry to an Early Intervention Service and following 18 months of specialist care. METHODS: Face-to-face interviews were conducted with 149 individuals who presented to an Early Intervention Service for the first time with @entity2 in the London borough of Lambeth, UK. A range of demographic and clinical measures were completed including self-reported history of victimization along with the type of crime and its subjective effect on the @entity0 . Clinical and functional outcomes at 18-month follow up were ascertained from clinical case notes by a psychiatrist. RESULTS: A large proportion of @entity0 (n   =   64, 43%) reported a history of crime victimization. This was associated with significantly higher levels of @entity1 and substance misuse at initial presentation. Being a victim of a crime was not significantly associated with poorer clinical or functional outcomes after 18 months of specialist care. However, non-significant differences were found for those who reported crime victimization in terms of their increased use of illegal substances or having assaulted someone else during the follow-up period. CONCLUSION: Past experience of being a victim of crime appears to be common in @entity0 presenting for the first time with @entity2 and is associated with increased likelihood of comorbidity. Thus, Early Intervention Services should consider screening for past victimization and be prepared to deal with comorbid problems. The impact of crime victimization on clinical and functional outcomes requires investigation over a longer period of time.

title: Impact of crime victimization on initial presentation to an early intervention for XXXX service and 18-month outcomes.

answer: @entity2


abstract: OBJECTIVES: @entity0 who undergo lung resection surgery are at risk for postoperative morbidity and mortality. Appropriate selection of the surgical candidate is crucial in the treatment of @entity1 . Heart rate recovery is a measure of physical fitness. We aimed to investigate the association of impaired heart rate recovery with @entity3 after lung resection surgery for treatment of @entity1 . METHODS: Data from consecutive @entity0 who, between 2009 and 2013, underwent heart rate recovery evaluation after 6-minute walk tests before lung resection surgery were retrospectively reviewed. Impaired heart rate recovery was defined as a 12-beat or less decrease in peak heart rate at 1 minute after the 6-minute walk test. @entity2 were as defined by the Society of Thoracic Surgeons General Thoracic Surgery Database. Logistic regression was performed, including previously known risk factors for @entity2 after lung resection surgery. RESULTS: A total of 96 @entity0 had heart rate recovery evaluated within 6 months of lung resection surgery for treatment of @entity1 . Thirty-one @entity0 had impaired heart rate recovery, 17 of whom (55%) had @entity3 . A total of 65 @entity0 had normal heart rate recovery, 17 of whom (26%) had @entity3 . In multivariable logistic regression analysis, impaired heart rate recovery was significantly associated with @entity2 (odds ratio, 4.97; confidence interval, 1.79-13.8; P  =  .002). No @entity0 died within 30 days after surgery. CONCLUSIONS: Impaired heart rate recovery after the 6-minute walk test is associated with @entity2 in @entity0 who underwent lung resection surgery for treatment of @entity1 .

title: Association of impaired heart rate recovery with @entity3 after XXXX resection surgery.

answer: @entity1


abstract: OBJECTIVES: @entity0 who undergo lung resection surgery are at risk for postoperative morbidity and mortality. Appropriate selection of the surgical candidate is crucial in the treatment of @entity1 . Heart rate recovery is a measure of physical fitness. We aimed to investigate the association of impaired heart rate recovery with @entity3 after lung resection surgery for treatment of @entity1 . METHODS: Data from consecutive @entity0 who, between 2009 and 2013, underwent heart rate recovery evaluation after 6-minute walk tests before lung resection surgery were retrospectively reviewed. Impaired heart rate recovery was defined as a 12-beat or less decrease in peak heart rate at 1 minute after the 6-minute walk test. @entity2 were as defined by the Society of Thoracic Surgeons General Thoracic Surgery Database. Logistic regression was performed, including previously known risk factors for @entity2 after lung resection surgery. RESULTS: A total of 96 @entity0 had heart rate recovery evaluated within 6 months of lung resection surgery for treatment of @entity1 . Thirty-one @entity0 had impaired heart rate recovery, 17 of whom (55%) had @entity3 . A total of 65 @entity0 had normal heart rate recovery, 17 of whom (26%) had @entity3 . In multivariable logistic regression analysis, impaired heart rate recovery was significantly associated with @entity2 (odds ratio, 4.97; confidence interval, 1.79-13.8; P  =  .002). No @entity0 died within 30 days after surgery. CONCLUSIONS: Impaired heart rate recovery after the 6-minute walk test is associated with @entity2 in @entity0 who underwent lung resection surgery for treatment of @entity1 .

title: Association of impaired heart rate recovery with XXXX after @entity1 resection surgery.

answer: @entity3


abstract: INTRODUCTION: @entity6 ( @entity6 ) are rare @entity5 . To date, capsular and/or vascular invasion are the only findings predicting @entity1 . Recently, mutation of 19p13, encoding two proteins involved in cell proliferation and apoptosis ( @entity9 and @entity8 ), has been described. The aim of our study is to evaluate the cellular proliferation index (Ki67), @entity9 and @entity8 expression as diagnostic markers of @entity1 in HCT. MATERIALS AND METHODS: Eighty @entity0 with HCT (32 @entity2 , 48 @entity3 ) whom underwent surgery in our center were included. Samples of both @entity4 and adjacent normal thyroid tissue were analyzed by means of tissue micro-arrays. Correlations between expressions of Ki67, @entity9 and @entity8 and final histology were analyzed. RESULTS: Mean size of the lesion was higher in @entity2 than in @entity3 (p  =  0.01). @entity9 and @entity8 were significantly underexpressed in Hurthle cells @entity1 compared to normal tissue (p  =  0.0004 and p  =  0.0001, respectively). Ki67 and @entity9 were, respectively, higher and down-expressed in @entity2 compared to @entity3 (p  =  0.0004 and p  =  0.005, respectively). On multivariate analysis, size correlates with @entity2 diagnosis. Neither @entity9 nor Ki67 index was related to size. The expression of @entity8 was reduced in both @entity7 but differences were not statistically significant (p  =  0.13). CONCLUSIONS: Our study suggest that Ki67 and @entity9 correlate with @entity1 in HCT. The expression of @entity8 is down-regulated in HCT, but it is not diagnostic of @entity2 . Ki67 and @entity9 may potentially help as cytological markers of @entity1 in HCT.

title: Thyroid H  rthle cell XXXX : research of potential markers of @entity1 .

answer: @entity1


abstract: INTRODUCTION: @entity6 ( @entity6 ) are rare @entity5 . To date, capsular and/or vascular invasion are the only findings predicting @entity1 . Recently, mutation of 19p13, encoding two proteins involved in cell proliferation and apoptosis ( @entity9 and @entity8 ), has been described. The aim of our study is to evaluate the cellular proliferation index (Ki67), @entity9 and @entity8 expression as diagnostic markers of @entity1 in HCT. MATERIALS AND METHODS: Eighty @entity0 with HCT (32 @entity2 , 48 @entity3 ) whom underwent surgery in our center were included. Samples of both @entity4 and adjacent normal thyroid tissue were analyzed by means of tissue micro-arrays. Correlations between expressions of Ki67, @entity9 and @entity8 and final histology were analyzed. RESULTS: Mean size of the lesion was higher in @entity2 than in @entity3 (p  =  0.01). @entity9 and @entity8 were significantly underexpressed in Hurthle cells @entity1 compared to normal tissue (p  =  0.0004 and p  =  0.0001, respectively). Ki67 and @entity9 were, respectively, higher and down-expressed in @entity2 compared to @entity3 (p  =  0.0004 and p  =  0.005, respectively). On multivariate analysis, size correlates with @entity2 diagnosis. Neither @entity9 nor Ki67 index was related to size. The expression of @entity8 was reduced in both @entity7 but differences were not statistically significant (p  =  0.13). CONCLUSIONS: Our study suggest that Ki67 and @entity9 correlate with @entity1 in HCT. The expression of @entity8 is down-regulated in HCT, but it is not diagnostic of @entity2 . Ki67 and @entity9 may potentially help as cytological markers of @entity1 in HCT.

title: Thyroid H  rthle cell @entity1 : research of potential markers of XXXX .

answer: @entity1


abstract: PURPOSE: To compare outcomes of prosthetic arthroplasty versus arthrodesis to treat index finger proximal interphalangeal (PIP) joint @entity3 . METHODS: @entity0 with @entity2 or @entity3 of index finger PIP joints were evaluated. Digit range of motion, grip and pinch strength, @entity0 -rated @entity1 and satisfaction scores, Michigan Hand Questionnaire scores, and complications were recorded. RESULTS: A total of 79 finger PIP joints were followed for a median of 67 months overall (72 mo for arthroplasty and 8 mo for the arthrodesis group). Sixty-five were treated with arthroplasty and 14 with arthrodesis. @entity0 undergoing arthroplasty experienced no significant postoperative change in PIP joint range of motion whereas all preoperative @entity4 was eliminated after arthrodesis. @entity0 undergoing arthroplasty experienced significant postoperative improvement in opposition pinch. In contrast, @entity0 undergoing arthrodesis experienced significant improvement in both opposition and apposition pinch. There were no differences in @entity1 relief, satisfaction, or Michigan Hand Questionnaire scores between treatment groups. @entity0 undergoing arthroplasty had a significantly greater mean number of complications per year and mean number of complications in the first year postoperatively. There was a 4.3 times increased risk of complication in @entity0 undergoing arthroplasty versus arthrodesis, and Kaplan-Meier analysis revealed a shorter time to first complication among @entity0 undergoing arthroplasty. CONCLUSIONS: The decision for prosthetic arthroplasty versus arthrodesis in the index finger of @entity0 with @entity2 or @entity3 must be made with @entity0 goals in mind and in light of greater risk of complications associated with arthroplasty. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic III.

title: Prosthetic Arthroplasty Versus Arthrodesis for @entity2 and XXXX of the Index Finger Proximal Interphalangeal Joint.

answer: @entity3


abstract: PURPOSE: To compare outcomes of prosthetic arthroplasty versus arthrodesis to treat index finger proximal interphalangeal (PIP) joint @entity3 . METHODS: @entity0 with @entity2 or @entity3 of index finger PIP joints were evaluated. Digit range of motion, grip and pinch strength, @entity0 -rated @entity1 and satisfaction scores, Michigan Hand Questionnaire scores, and complications were recorded. RESULTS: A total of 79 finger PIP joints were followed for a median of 67 months overall (72 mo for arthroplasty and 8 mo for the arthrodesis group). Sixty-five were treated with arthroplasty and 14 with arthrodesis. @entity0 undergoing arthroplasty experienced no significant postoperative change in PIP joint range of motion whereas all preoperative @entity4 was eliminated after arthrodesis. @entity0 undergoing arthroplasty experienced significant postoperative improvement in opposition pinch. In contrast, @entity0 undergoing arthrodesis experienced significant improvement in both opposition and apposition pinch. There were no differences in @entity1 relief, satisfaction, or Michigan Hand Questionnaire scores between treatment groups. @entity0 undergoing arthroplasty had a significantly greater mean number of complications per year and mean number of complications in the first year postoperatively. There was a 4.3 times increased risk of complication in @entity0 undergoing arthroplasty versus arthrodesis, and Kaplan-Meier analysis revealed a shorter time to first complication among @entity0 undergoing arthroplasty. CONCLUSIONS: The decision for prosthetic arthroplasty versus arthrodesis in the index finger of @entity0 with @entity2 or @entity3 must be made with @entity0 goals in mind and in light of greater risk of complications associated with arthroplasty. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic III.

title: Prosthetic Arthroplasty Versus Arthrodesis for XXXX and @entity3 of the Index Finger Proximal Interphalangeal Joint.

answer: @entity2


abstract: Recent evidence indicates that the vasculature contains mesenchymal stem cells (MSCs). We hypothesized that @entity4 ( @entity4 ) type 2 receptors (AT2Rs) play a role in the osteogenesis of MSCs and may have a role in @entity2 . @entity0 MSCs were differentiated into osteoblasts. Expression of AT2R was significantly increased during osteogenesis, whereas the expression of @entity4 type 1 receptors was not significantly changed. Incubation with the AT2R blocker @entity6 with or without @entity4 significantly inhibited @entity1 deposition, whereas type 1 receptor blocker @entity3 had no significant effect. @entity6 inhibited @entity5 ( @entity5 ) phosphorylation in the osteogenic process, whereas @entity3 had no effect. Furthermore, @entity6 combined with @entity4 also inhibited acute @entity5 phosphorylation in MSCs induced by insulin. In conclusion, AT2R is upregulated during osteogenesis. Blockade of AT2R inhibits osteogenesis and @entity5 phosphorylation of @entity0 MSCs. These results provide a novel insight into the pathophysiology of @entity2 .

title: Blockade of angiotensin II type 2 receptor by XXXX inhibits osteogenic differentiation of @entity0 mesenchymal stem cells via inhibition of @entity5 signaling.

answer: @entity6


abstract: Recent evidence indicates that the vasculature contains mesenchymal stem cells (MSCs). We hypothesized that @entity4 ( @entity4 ) type 2 receptors (AT2Rs) play a role in the osteogenesis of MSCs and may have a role in @entity2 . @entity0 MSCs were differentiated into osteoblasts. Expression of AT2R was significantly increased during osteogenesis, whereas the expression of @entity4 type 1 receptors was not significantly changed. Incubation with the AT2R blocker @entity6 with or without @entity4 significantly inhibited @entity1 deposition, whereas type 1 receptor blocker @entity3 had no significant effect. @entity6 inhibited @entity5 ( @entity5 ) phosphorylation in the osteogenic process, whereas @entity3 had no effect. Furthermore, @entity6 combined with @entity4 also inhibited acute @entity5 phosphorylation in MSCs induced by insulin. In conclusion, AT2R is upregulated during osteogenesis. Blockade of AT2R inhibits osteogenesis and @entity5 phosphorylation of @entity0 MSCs. These results provide a novel insight into the pathophysiology of @entity2 .

title: Blockade of angiotensin II type 2 receptor by @entity6 inhibits osteogenic differentiation of @entity0 mesenchymal stem cells via inhibition of XXXX signaling.

answer: @entity5


abstract: Recent evidence indicates that the vasculature contains mesenchymal stem cells (MSCs). We hypothesized that @entity4 ( @entity4 ) type 2 receptors (AT2Rs) play a role in the osteogenesis of MSCs and may have a role in @entity2 . @entity0 MSCs were differentiated into osteoblasts. Expression of AT2R was significantly increased during osteogenesis, whereas the expression of @entity4 type 1 receptors was not significantly changed. Incubation with the AT2R blocker @entity6 with or without @entity4 significantly inhibited @entity1 deposition, whereas type 1 receptor blocker @entity3 had no significant effect. @entity6 inhibited @entity5 ( @entity5 ) phosphorylation in the osteogenic process, whereas @entity3 had no effect. Furthermore, @entity6 combined with @entity4 also inhibited acute @entity5 phosphorylation in MSCs induced by insulin. In conclusion, AT2R is upregulated during osteogenesis. Blockade of AT2R inhibits osteogenesis and @entity5 phosphorylation of @entity0 MSCs. These results provide a novel insight into the pathophysiology of @entity2 .

title: Blockade of angiotensin II type 2 receptor by @entity6 inhibits osteogenic differentiation of XXXX mesenchymal stem cells via inhibition of @entity5 signaling.

answer: @entity0


abstract: BACKGROUND: Recent evidence suggests that the insular cortex may play an important role in cognitive and emotional processes that facilitate drug use but it is unclear whether changes to the insula would result in sustained abstinence. To better understand the role of the insula in maintaining abstinence, we examined quitting patterns in smokers with acute damage to their insula relative to other regions. DESIGN: Prospective cohort study with 3month follow-up, beginning June 2013 and ending May 2014. SETTING: Three acute care hospitals in Rochester, NY. @entity0 : One-hundred-fifty-six current smokers hospitalized for acute @entity3 ; 38 with insular @entity4 and 118 with non-insular @entity4 , assessed by 3 neuroradiologists. MEASUREMENTS: Self-reported smoking status (seven-day point prevalence and continuous abstinence), complete abstinence from any @entity5 product, and disruption of smoking addiction (defined by criteria on smoking status, difficulty of quitting, and urge) were assessed at three months post- @entity2 . Time to relapse (in days) after discharge was also assessed. RESULTS: Insular damage was associated with increased odds of three-month continuous abstinence (OR=3.71, 95% CI: 1.59, 8.65) and complete cessation from any @entity5 product (OR=2.72, 95% CI: 1.19, 6.22). Average time to relapse was longer in the insular-damaged group (17.50days, SD=19.82) relative to @entity1 (10.42days, SD=18.49). Among quitters, insular damage was also associated with higher relative odds of experiencing a disruption of addiction compared to @entity1 (adjusted OR=5.60, 95% CI: 1.52, 20.56). CONCLUSIONS: These findings support the potential role of the insular cortex in maintaining smoking and @entity5 abstinence. Further research is needed to establish whether the insula may be a novel target for smoking cessation interventions.

title: Smoking cessation behaviors three months following acute insular damage from XXXX .

answer: @entity2


abstract: The @entity0 Tribbles (TRB)-related pseudokinases are CAMK ( @entity3 /calmodulin-dependent protein kinase)-related family members that have evolved a series of highly unusual motifs in the 'pseudocatalytic' domain. In canonical kinases, conserved @entity5 bind to divalent metal ions and align @entity4 prior to efficient @entity7 -transfer to substrates. However, in pseudokinases, atypical residues give rise to diverse and often unstudied biochemical and structural features that are thought to be central to cellular functions. TRB proteins play a crucial role in multiple signalling networks and overexpression confers @entity1 phenotypes on @entity0 cells, marking TRB pseudokinases out as a novel class of drug target. In the present paper, we report that the @entity0 pseudokinase @entity10 retains the ability to both bind and hydrolyse @entity4 weakly in  vitro. Kinase activity is metal-independent and involves a catalytic @entity2 residue, which is conserved in TRB proteins throughout evolution alongside several unique @entity5 in the active site. A similar low level of autophosphorylation is also preserved in the closely related @entity0 @entity8 . By employing chemical genetics, we establish that the @entity6 -binding site of an 'analogue-sensitive' (AS) @entity10 mutant can be targeted with specific bulky ligands of the @entity9 (PP) chemotype. Our analysis confirms that @entity10 retains low levels of @entity4 binding and/or catalysis that is targetable with small molecules. Given the significant clinical successes associated with targeting of @entity1 -associated kinases with small molecule inhibitors, it is likely that similar approaches will be useful for further evaluating the TRB pseudokinases, with the translation of this information likely to furnish new leads for drug discovery.

title: The XXXX ( @entity10 ) pseudokinase binds to @entity4 and autophosphorylates in a metal-independent manner.

answer: @entity10


abstract: The @entity0 Tribbles (TRB)-related pseudokinases are CAMK ( @entity3 /calmodulin-dependent protein kinase)-related family members that have evolved a series of highly unusual motifs in the 'pseudocatalytic' domain. In canonical kinases, conserved @entity5 bind to divalent metal ions and align @entity4 prior to efficient @entity7 -transfer to substrates. However, in pseudokinases, atypical residues give rise to diverse and often unstudied biochemical and structural features that are thought to be central to cellular functions. TRB proteins play a crucial role in multiple signalling networks and overexpression confers @entity1 phenotypes on @entity0 cells, marking TRB pseudokinases out as a novel class of drug target. In the present paper, we report that the @entity0 pseudokinase @entity10 retains the ability to both bind and hydrolyse @entity4 weakly in  vitro. Kinase activity is metal-independent and involves a catalytic @entity2 residue, which is conserved in TRB proteins throughout evolution alongside several unique @entity5 in the active site. A similar low level of autophosphorylation is also preserved in the closely related @entity0 @entity8 . By employing chemical genetics, we establish that the @entity6 -binding site of an 'analogue-sensitive' (AS) @entity10 mutant can be targeted with specific bulky ligands of the @entity9 (PP) chemotype. Our analysis confirms that @entity10 retains low levels of @entity4 binding and/or catalysis that is targetable with small molecules. Given the significant clinical successes associated with targeting of @entity1 -associated kinases with small molecule inhibitors, it is likely that similar approaches will be useful for further evaluating the TRB pseudokinases, with the translation of this information likely to furnish new leads for drug discovery.

title: The @entity10 ( XXXX ) pseudokinase binds to @entity4 and autophosphorylates in a metal-independent manner.

answer: @entity10


abstract: The @entity0 Tribbles (TRB)-related pseudokinases are CAMK ( @entity3 /calmodulin-dependent protein kinase)-related family members that have evolved a series of highly unusual motifs in the 'pseudocatalytic' domain. In canonical kinases, conserved @entity5 bind to divalent metal ions and align @entity4 prior to efficient @entity7 -transfer to substrates. However, in pseudokinases, atypical residues give rise to diverse and often unstudied biochemical and structural features that are thought to be central to cellular functions. TRB proteins play a crucial role in multiple signalling networks and overexpression confers @entity1 phenotypes on @entity0 cells, marking TRB pseudokinases out as a novel class of drug target. In the present paper, we report that the @entity0 pseudokinase @entity10 retains the ability to both bind and hydrolyse @entity4 weakly in  vitro. Kinase activity is metal-independent and involves a catalytic @entity2 residue, which is conserved in TRB proteins throughout evolution alongside several unique @entity5 in the active site. A similar low level of autophosphorylation is also preserved in the closely related @entity0 @entity8 . By employing chemical genetics, we establish that the @entity6 -binding site of an 'analogue-sensitive' (AS) @entity10 mutant can be targeted with specific bulky ligands of the @entity9 (PP) chemotype. Our analysis confirms that @entity10 retains low levels of @entity4 binding and/or catalysis that is targetable with small molecules. Given the significant clinical successes associated with targeting of @entity1 -associated kinases with small molecule inhibitors, it is likely that similar approaches will be useful for further evaluating the TRB pseudokinases, with the translation of this information likely to furnish new leads for drug discovery.

title: The @entity10 ( @entity10 ) pseudokinase binds to XXXX and autophosphorylates in a metal-independent manner.

answer: @entity4


abstract: OBJECTIVES: To evaluate @entity4 ( @entity4 ) as a prognostic tool after resection of @entity2 . METHODS: Sixty @entity4 examinations were evaluated for perioperative @entity3 , @entity1 growth between diagnosis and @entity4 , contrast enhancement pattern, and extent of resection (EOR). The EOR was approached with the subjective evaluation of radiologists and by quantifying volumes. These parameters were tested as predictors of survival using the Kaplan-Meier method. RESULTS: Contrast enhancement was found in 59 @entity0 (59/60; 98  %). Showing a thin-linear pattern of enhancement was the most favourable finding. @entity0 with this pattern survived longer than @entity0 with thick-linear (median overall survival (OS) thin-linear=609  days; thick-linear=432  days; P   =   .023) or nodular (median OS   =   318  days; P   =   .001) enhancements. The subjective evaluation of the EOR performed better than its quantification. @entity0 survived longer when resection was total (median OS total resection=609  days; subtotal=371  days; P   =   .001). When resection was subtotal, @entity0 survived longer if it was superior to 95  % (median OS resection superior to 95  %=559  days; inferior to 95  %=256  days; P   =   .034). CONCLUSIONS: @entity4 provides valuable prognostic information after surgical resection of @entity2 . A thin-linear pattern of contrast enhancement is the most favourable finding. Further prognostic stratification may be obtained by assessing the EOR. KEY POINTS:     Some kind of contrast enhancement may be found in most @entity4 examinations.     Thin-linear enhancements in the @entity4 may be considered benign findings.     The EOR evaluated in the @entity4 may stratify prognostic groups of @entity0 .     The subjective evaluation of the EOR performs slightly better than its quantification.

title: Early post-operative magnetic resonance imaging in XXXX : correlation among radiological findings and overall survival in 60 @entity0 .

answer: @entity2


abstract: OBJECTIVES: To evaluate @entity4 ( @entity4 ) as a prognostic tool after resection of @entity2 . METHODS: Sixty @entity4 examinations were evaluated for perioperative @entity3 , @entity1 growth between diagnosis and @entity4 , contrast enhancement pattern, and extent of resection (EOR). The EOR was approached with the subjective evaluation of radiologists and by quantifying volumes. These parameters were tested as predictors of survival using the Kaplan-Meier method. RESULTS: Contrast enhancement was found in 59 @entity0 (59/60; 98  %). Showing a thin-linear pattern of enhancement was the most favourable finding. @entity0 with this pattern survived longer than @entity0 with thick-linear (median overall survival (OS) thin-linear=609  days; thick-linear=432  days; P   =   .023) or nodular (median OS   =   318  days; P   =   .001) enhancements. The subjective evaluation of the EOR performed better than its quantification. @entity0 survived longer when resection was total (median OS total resection=609  days; subtotal=371  days; P   =   .001). When resection was subtotal, @entity0 survived longer if it was superior to 95  % (median OS resection superior to 95  %=559  days; inferior to 95  %=256  days; P   =   .034). CONCLUSIONS: @entity4 provides valuable prognostic information after surgical resection of @entity2 . A thin-linear pattern of contrast enhancement is the most favourable finding. Further prognostic stratification may be obtained by assessing the EOR. KEY POINTS:     Some kind of contrast enhancement may be found in most @entity4 examinations.     Thin-linear enhancements in the @entity4 may be considered benign findings.     The EOR evaluated in the @entity4 may stratify prognostic groups of @entity0 .     The subjective evaluation of the EOR performs slightly better than its quantification.

title: Early post-operative magnetic resonance imaging in @entity2 : correlation among radiological findings and overall survival in 60 XXXX .

answer: @entity0


abstract: UNASSIGNED: Intracellular @entity3 accumulation is associated with cell death in several @entity1 including @entity7 , but the exact mechanisms of @entity5 need to be clarified. We used organotypic hippocampal slice culture - cultures subjected to @entity0 - @entity2 deprivation (OGD) mimicking the in vivo situation to investigate the events underlying ectopic @entity5 . @entity4 staining indicating @entity3 deposition was observed in the cornu ammonis (CA)1 and dentate gyrus regions in control hippocampal slices despite no specific labeling for cell death markers. Electron microscopy using the @entity8 / @entity9 method revealed scattered degenerated cells throughout the normally appearing @entity6 region. They contained electron-dense precipitates within mitochondria, and electron probe microanalysis confirmed that they were calcifying mitochondria. Selective @entity3 deposition was noted within, but not beyond, mitochondria in these mineralized cells. They showed ultrastructural features of non-necrotic, non-apoptotic cell death and retained their compact ultrastructure, even after the majority of mitochondria were calcified. Unexpectedly, no intracellular @entity5 was noted in necrotic @entity6 pyramidal cells after OGD, and there was no progression of @entity5 in OGD-lesioned slices. In addition, mineralized cells in both control and OGD-lesioned slices were closely associated with or completely engulfed by astrocytes but not microglia. These astrocytes were laden with heterogeneous cytoplasmic inclusions that appeared to be related with their phagocytic activity. These data demonstrate that microcalcification specifically associated with mitochondria might lead to a novel type of cell death and suggest that astrocytes may be involved in the phagocytosis of these mineralized cells and possibly in the regulation of ectopic @entity5 .

title: Ultrastructural investigation of microcalcification and the role of XXXX - @entity2 deprivation in cultured rat hippocampal slices.

answer: @entity0


abstract: UNASSIGNED: Intracellular @entity3 accumulation is associated with cell death in several @entity1 including @entity7 , but the exact mechanisms of @entity5 need to be clarified. We used organotypic hippocampal slice culture - cultures subjected to @entity0 - @entity2 deprivation (OGD) mimicking the in vivo situation to investigate the events underlying ectopic @entity5 . @entity4 staining indicating @entity3 deposition was observed in the cornu ammonis (CA)1 and dentate gyrus regions in control hippocampal slices despite no specific labeling for cell death markers. Electron microscopy using the @entity8 / @entity9 method revealed scattered degenerated cells throughout the normally appearing @entity6 region. They contained electron-dense precipitates within mitochondria, and electron probe microanalysis confirmed that they were calcifying mitochondria. Selective @entity3 deposition was noted within, but not beyond, mitochondria in these mineralized cells. They showed ultrastructural features of non-necrotic, non-apoptotic cell death and retained their compact ultrastructure, even after the majority of mitochondria were calcified. Unexpectedly, no intracellular @entity5 was noted in necrotic @entity6 pyramidal cells after OGD, and there was no progression of @entity5 in OGD-lesioned slices. In addition, mineralized cells in both control and OGD-lesioned slices were closely associated with or completely engulfed by astrocytes but not microglia. These astrocytes were laden with heterogeneous cytoplasmic inclusions that appeared to be related with their phagocytic activity. These data demonstrate that microcalcification specifically associated with mitochondria might lead to a novel type of cell death and suggest that astrocytes may be involved in the phagocytosis of these mineralized cells and possibly in the regulation of ectopic @entity5 .

title: Ultrastructural investigation of microcalcification and the role of @entity0 - XXXX deprivation in cultured rat hippocampal slices.

answer: @entity2


abstract: BACKGROUND: The pharmacological prevention of @entity5 ( @entity5 ) has so far been carried out mainly with classic (low-molecular-weight heparins, coumarins) or new direct oral anticoagulants (DOACs). The role of antiplatelet treatment with aspirin is controversial. New data, however, suggest a paradigm shift with the reassessment of aspirin as part of a multimodal antithrombotic approach. OBJECTIVE: The article provides an up-to-date overview of the role of antiplatelet treatment with aspirin in the primary and secondary prevention of @entity5 . CURRENT DATA AND RESULTS: Primary prevention of surgery-related @entity5 with anticoagulants is effective but apparently not superior to a multimodal approach with aspirin, pneumatic compression, and early mobilization. Against this background, aspirin is now also included in the @entity5 prevention guidelines in the US (ACCP, AAOS) but not in the UK (NICE) and Germany (AMWF). A final evaluation of aspirin as compared to classic anticoagulants and DOACs in primary prophylaxis requires further randomized controlled, prospective trials. These should also consider the iatrogenic risk of @entity2 as well as possible @entity1 , such as retarded wound healing that might require prolonged hospitalization. After ending guideline-conforming anticoagulant treatment in @entity0 with idiopathic @entity5 , administration of aspirin reduces the risk of recurrent @entity5 by about 40   % without increasing the risk of severe @entity2 (standardized INSPIRE evaluation of ASPIRE and WARFASA data). These data add to the current use of aspirin in the prevention of arterial @entity3 the new option of preventing spontaneous @entity5 . CONCLUSION: On the basis of new data from recent studies, an indication can be made for the use of aspirin, combined with other preventive measures, in the prevention of primary and secondary @entity4 .

title: [Aspirin and XXXX .]

answer: @entity4


abstract: OBJECTIVES: Iliac branch grafts (IBGs) are a validated option for the treatment of @entity2 preserving @entity4 ( @entity4 ) flow. @entity4 @entity1 (IIAA) is a relative contraindication to IBG placement. The goal of this study was to review experience in managing @entity2 with concomitant IIAAs with extension of the @entity4 branch stent graft into the superior gluteal artery (SGA). METHODS: This retrospective study between May 2009 and November 2014 includes consecutive @entity0 who underwent placement of an IBG (Cook, Bloomington, IN, USA) with extension of the internal iliac component of the branch stent graft into the SGA because of @entity2 (>15  mm). The stent grafts used were Viabahn (Gore, Karlsruhe, Germany), Fluency (Bard, Flagstaff, AZ, USA), or iCast (Atrium, Hudson, NH, USA) proximally. Imaging follow up was with computed tomography angiography (CTA) within 30 days of device insertion and then annually. RESULTS: The procedure was performed on 15 @entity0 with a mean age of 76.8 years (SD 6.1 years). Twenty IIAAs were treated with a mean @entity4 and common iliac artery (CIA) diameter of 33  mm (SD 13  mm) and 35  mm (SD 11  mm) respectively. Technical success rate was 100%. One @entity0 who underwent simultaneous IBG and three vessel fenestrated @entity1 repair died of @entity5 2 days after the procedure. Mean imaging follow up with CTA was 18.3 months (SD 15.1 months). Primary patency of the SGA stent grafts was 100%. There was one case of @entity3 . All @entity0 were free from buttock claudication at follow up (mean: 19.7 months). Two @entity0 who had @entity4 embolization contralateral to the IBG placement suffered from unilateral lower limb monoparesis. CONCLUSIONS: Extension of the internal iliac component of IBGs into the SGA for distal seal is feasible and safe in the endovascular treatment of @entity2 with concomitant IIAs. Long-term results are needed to further validate this technique.

title: XXXX Repair Outcomes Using a Modification of the Iliac Branch Graft.

answer: @entity2


abstract: BACKGROUND: The objective of this study was to analyze the percentage as well as clinical and laboratory characteristics of @entity8 ( @entity8 ) in @entity0 admitted with @entity4 . Additionally, we looked for diagnostic criteria to distinguish @entity6 from @entity5 due to @entity8 . METHODS: Data collection was done retrospectively from 2007 until 2012. We identified 278 consecutive @entity0 , who were admitted to the department of Neurology due to @entity4 . @entity0 were routinely investigated for @entity8 including clinical neurological examination and cerebral spinal fluid (CSF) analysis. Demographic and clinical data were analyzed according to a standardized protocol. RESULTS: In 19 (male (m)  =  14/female (f)  =  5) out of 278 @entity0 (7  %), a diagnosis of @entity8 was established. There were 8 @entity0 (3  %) identified with varicella zoster ( @entity7 ) (m  =  7/f  =  1) and 13 @entity0 (5  %) with @entity5 due to @entity1 (m  =  5/f  =  8). A total of 207 @entity0 (75  %) were diagnosed as @entity6 (m  =  110/f  =  97). Compared with CSF of @entity0 with @entity5 due to @entity7 and @entity1 , @entity0 with @entity8 showed higher cell count, protein and @entity3 levels, whereas @entity0 with @entity5 due to @entity1 showed higher @entity2 level. With respect to seasonal clustering, an accumulation of 74  % of the @entity8 cases was detected from June to October, whereas in the rest of the year there were only 26  % of the @entity8 cases. @entity0 with @entity6 are more evenly distributed over the year. Regarding neurological signs and symptoms, radicular symptoms were only reported in the @entity8 group. Despite radicular symptoms for @entity8 , no specific signs or symptoms were found for @entity5 due to @entity7 , @entity6 , or @entity1 . CONCLUSIONS: According to the results of our study, we recommend CSF testing in any case for @entity0 with @entity5 in an endemic area from June to October especially if additional radicular symptoms are present. To establish recommendations for a diagnostic workup in @entity0 with @entity5 in areas endemic for @entity9 , the seasonal clustering of @entity8 as well as specific clinical features should also be confirmed in a future prospective trial.

title: @entity4 as an initial symptom of XXXX in an Austrian endemic area.

answer: @entity8


abstract: BACKGROUND: The objective of this study was to analyze the percentage as well as clinical and laboratory characteristics of @entity8 ( @entity8 ) in @entity0 admitted with @entity4 . Additionally, we looked for diagnostic criteria to distinguish @entity6 from @entity5 due to @entity8 . METHODS: Data collection was done retrospectively from 2007 until 2012. We identified 278 consecutive @entity0 , who were admitted to the department of Neurology due to @entity4 . @entity0 were routinely investigated for @entity8 including clinical neurological examination and cerebral spinal fluid (CSF) analysis. Demographic and clinical data were analyzed according to a standardized protocol. RESULTS: In 19 (male (m)  =  14/female (f)  =  5) out of 278 @entity0 (7  %), a diagnosis of @entity8 was established. There were 8 @entity0 (3  %) identified with varicella zoster ( @entity7 ) (m  =  7/f  =  1) and 13 @entity0 (5  %) with @entity5 due to @entity1 (m  =  5/f  =  8). A total of 207 @entity0 (75  %) were diagnosed as @entity6 (m  =  110/f  =  97). Compared with CSF of @entity0 with @entity5 due to @entity7 and @entity1 , @entity0 with @entity8 showed higher cell count, protein and @entity3 levels, whereas @entity0 with @entity5 due to @entity1 showed higher @entity2 level. With respect to seasonal clustering, an accumulation of 74  % of the @entity8 cases was detected from June to October, whereas in the rest of the year there were only 26  % of the @entity8 cases. @entity0 with @entity6 are more evenly distributed over the year. Regarding neurological signs and symptoms, radicular symptoms were only reported in the @entity8 group. Despite radicular symptoms for @entity8 , no specific signs or symptoms were found for @entity5 due to @entity7 , @entity6 , or @entity1 . CONCLUSIONS: According to the results of our study, we recommend CSF testing in any case for @entity0 with @entity5 in an endemic area from June to October especially if additional radicular symptoms are present. To establish recommendations for a diagnostic workup in @entity0 with @entity5 in areas endemic for @entity9 , the seasonal clustering of @entity8 as well as specific clinical features should also be confirmed in a future prospective trial.

title: XXXX as an initial symptom of @entity8 in an Austrian endemic area.

answer: @entity4


abstract: OBJECTIVE: There is an increased interest in developing gene therapy approaches for local delivery of therapeutic genes in @entity0 with @entity4 . Intra-articular (i.a.) gene delivery, using an adeno-associated virus encoding a @entity3 soluble receptor, resulted in reduced paw swelling in an @entity4 animal model, but i.a. treatment with a similar vector did not induce robust clinical improvement in @entity0 . It is unclear whether this can be explained by for instance insufficient transduction efficiency or the fact that @entity3 is not a good therapeutic target for i.a treatment. The objective of this study was to explore the effects of i.a @entity3 blockade. METHODS: Thirty-one @entity0 with @entity2 or @entity5 were assigned to a single i.a. injection of 25mg etanercept or placebo in a double-blind randomised controlled clinical trial. The primary end point was target joint improvement, determined by a composite change index. RESULTS: Twenty-two @entity0 received etanercept and 9 received placebo. Treatment was generally well tolerated. Treatment with etanercept resulted in a prompt and statistically significant improvement of the index (P<0.001) in comparison with placebo. As expected in light of the half-life of etanercept, the beneficial effect was transient and only statistically significant at week 1 and 2 after i.a. injection. CONCLUSION: The results support the development of novel approaches for long-term inhibition of @entity3 at the site of @entity1 , such as gene therapy. TRIAL REGISTRATION: The Netherlands National Trial Register (NTR), www.trialregister.nl, NTR-1210.

title: Intra-articular etanercept treatment in @entity4 : A randomized double-blind placebo-controlled proof of mechanism clinical trial validating XXXX as a potential therapeutic target for local treatment.

answer: @entity3


abstract: OBJECTIVE: There is an increased interest in developing gene therapy approaches for local delivery of therapeutic genes in @entity0 with @entity4 . Intra-articular (i.a.) gene delivery, using an adeno-associated virus encoding a @entity3 soluble receptor, resulted in reduced paw swelling in an @entity4 animal model, but i.a. treatment with a similar vector did not induce robust clinical improvement in @entity0 . It is unclear whether this can be explained by for instance insufficient transduction efficiency or the fact that @entity3 is not a good therapeutic target for i.a treatment. The objective of this study was to explore the effects of i.a @entity3 blockade. METHODS: Thirty-one @entity0 with @entity2 or @entity5 were assigned to a single i.a. injection of 25mg etanercept or placebo in a double-blind randomised controlled clinical trial. The primary end point was target joint improvement, determined by a composite change index. RESULTS: Twenty-two @entity0 received etanercept and 9 received placebo. Treatment was generally well tolerated. Treatment with etanercept resulted in a prompt and statistically significant improvement of the index (P<0.001) in comparison with placebo. As expected in light of the half-life of etanercept, the beneficial effect was transient and only statistically significant at week 1 and 2 after i.a. injection. CONCLUSION: The results support the development of novel approaches for long-term inhibition of @entity3 at the site of @entity1 , such as gene therapy. TRIAL REGISTRATION: The Netherlands National Trial Register (NTR), www.trialregister.nl, NTR-1210.

title: Intra-articular etanercept treatment in XXXX : A randomized double-blind placebo-controlled proof of mechanism clinical trial validating @entity3 as a potential therapeutic target for local treatment.

answer: @entity4


abstract: BACKGROUND: Anthropometry is becoming a popular method for diagnostics of @entity1 in pediatric clinical practice. The aim of this study was to assess the growth changes in craniofacial parameters in @entity0 with @entity3 and @entity5 . METHODS: Inclusion criteria for the study were presence of @entity3 or @entity5 in a @entity0 with at least three anthropometric evaluations at our department. Studied @entity0 were aged from 1.0 month to 2.5 years with median age at the first and last anthropometric evaluation as 1.83 and 25.27 months, respectively. Further anthropometric results in @entity0 older than 2.5 years were excluded from the study. Statistical significance was tested by the Mann-Whitney test. RESULTS: The studied group consisted of 70.5% male @entity0 . The type of @entity3 was represented by @entity3 in 44.1%, by @entity3 in 45.6% and by @entity4 in 10.3% of the cases. Cranial index was proven as a suitable parameter for evaluating differences in the trend of growth in @entity3 (p<0.001) and also for evaluating post-operative results. Significance was found in width of the head (p=0.038) for @entity3 and in length of the head for @entity3 (p=0.001) in surgically treated @entity0 . Trend of cranial growth in operated @entity0 copied the curve of the norm but in higher or lower values which depends on the type of prematurely closed suture. CONCLUSION: Longitudinal anthropometric follow-up is an objective and measurable method that can accurately non-invasively and non-expensively assess skull growth in pediatric @entity0 with @entity2 .

title: Anthropometry of XXXX .

answer: @entity3


abstract: UNASSIGNED: Neural stem cells proliferate and differentiate into neurons and glial cells, being responsible for embryonic and postnatal development of the central nervous system (CNS) as well as for regeneration in the adult brain. These cells also play a key role in maintaining the physiological integrity of the CNS in face of @entity2 . The previous study has demonstrated that @entity3 (BK) treatment simultaneously induces neuronal enrichment (indicating that BK contributes to neurogenesis) and reduced proliferation rates during in vitro differentiation of @entity1 embryonic telencephalon neural precursor cells (NPCs). Here, we provide a mechanism for the unresolved question whether (i) the low rate of proliferation is owed to enhanced neurogenesis or, conversely, (ii) the alteration of the population ratio could result from low proliferation of NPCs and glial cells. In agreement with the previous study, BK promoted neuron-specific b3-tubulin and @entity4 expression in differentiating embryonic @entity0 neurospheres, whereas glial protein expression and global proliferation rates decreased. Furthermore, BK augmented the global frequency of cells in G0 -phase of cell cycle after differentiation. Heterogeneous cell populations were observed at this stage, including neurons that always remaining a quiescent state (G0 -phase). It is noteworthy that BK did not interfere with proliferation of any particular cell type, evidenced by coimmunostaining for nestin, b3-tubulin, glial fibrillary acidic protein (GFAP), and @entity5 ( @entity6 ). Thus, we conclude that neuronal enrichment is owing only to the fostering of neurogenesis, and that the low proliferation rate on the seventh day of differentiation is a consequence and not the cause of BK-induced neuronal enrichment.    2015 International Society for Advancement of Cytometry.

title: XXXX -induced inhibition of proliferation rate during neurosphere differentiation: Consequence or cause of neuronal enrichment?

answer: @entity3


abstract: BACKGROUND: Good clinical results have been reported for both surgical and conservative treatment of rotator cuff tears. The primary aim of this randomized controlled trial was to compare functional and radiologic improvement after surgical and conservative treatment of @entity3 cuff tears. METHODS: We conducted a randomized controlled trial that included 56 @entity0 with a degenerative full-thickness rotator cuff tear between January 2009 and December 2012; 31 @entity0 were treated conservatively, and rotator cuff repair was performed in 25 @entity0 . Outcome measures, including the Constant-Murley score (CMS), visual analog scale (VAS) @entity1 and @entity2 scores, were assessed preoperatively and after 6  weeks and 3, 6, and 12  months. Magnetic resonance imaging was performed preoperatively and at 12  months postoperatively. RESULTS: At 12  months postoperatively, the mean CMS was 81.9 (standard deviation [SD], 15.6) in the surgery group vs 73.7 (SD, 18.4) in the conservative group (P  =  .08). VAS @entity1 (P  =  .04) and @entity2 (P  =  .02) were significantly lower in the surgery group at the 12-month follow-up. A subgroup analysis showed postoperative CMS results were significantly better in surgically treated @entity0 without a retear compared with conservatively treated @entity0 (88.5 [SD, 6.2] vs 73.7 [SD, 18.4]). CONCLUSION: In our population of @entity0 with @entity3 cuff tears who were randomly treated by surgery or conservative protocol, we did not observe differences in functional outcome as measured with the CMS 1 year after treatment. However, significant differences in @entity1 and disabilities were observed in favor of surgical treatment. The best outcomes in function and @entity1 were seen in @entity0 with an intact rotator cuff postoperatively.

title: Comparing surgical repair with conservative treatment for XXXX cuff tears: a  randomized controlled trial.

answer: @entity3


abstract: UNASSIGNED: This study examined how a maternal @entity4 ( @entity4 ) during lactation and exposure of offspring to isolation stress influence the susceptibility of offspring to the development of @entity1 . C57BL/6J @entity0 were fed a commercial diet (CD) during pregnancy and a CD or @entity4 during lactation. Male offspring were weaned at three weeks of age, fed a CD until seven weeks of age, and fed a CD or @entity4 until 11 weeks of age. Offspring were housed alone (isolation stress) or at six per cage (ordinary circumstances). Thus, offspring were assigned to one of eight groups: dams fed a CD or @entity4 during lactation and offspring fed a CD or @entity4 and housed under ordinary circumstances or isolation stress. Serum @entity5 level was significantly elevated by isolation stress. High-fat feeding of offspring reduced their serum @entity5 level, which was significantly elevated by a maternal @entity4 . A maternal @entity4 and isolation stress had combined effects in elevating the serum @entity5 level. These findings suggest that a maternal @entity4 during lactation enhances the stress sensitivity of offspring. White adipose tissue weights were significantly increased by a maternal @entity4 and isolation stress and by their combination. In addition, significant adipocyte @entity3 was induced by a maternal @entity4 and isolation stress and exacerbated by their combination. Thus, a maternal @entity4 and isolation stress promote visceral fat accumulation and adipocyte @entity3 , accelerating the progression of @entity1 through their combined effects. The mechanism may involve enhanced @entity2 synthesis and lipid influx from blood into adipose tissue. These findings demonstrate that a maternal @entity4 during lactation may increase the susceptibility of offspring to the development of stress-induced @entity1 .

title: High Dietary Fat Intake during Lactation Promotes the Development of Social Stress-Induced XXXX in the Offspring of @entity0 .

answer: @entity1


abstract: UNASSIGNED: This study examined how a maternal @entity4 ( @entity4 ) during lactation and exposure of offspring to isolation stress influence the susceptibility of offspring to the development of @entity1 . C57BL/6J @entity0 were fed a commercial diet (CD) during pregnancy and a CD or @entity4 during lactation. Male offspring were weaned at three weeks of age, fed a CD until seven weeks of age, and fed a CD or @entity4 until 11 weeks of age. Offspring were housed alone (isolation stress) or at six per cage (ordinary circumstances). Thus, offspring were assigned to one of eight groups: dams fed a CD or @entity4 during lactation and offspring fed a CD or @entity4 and housed under ordinary circumstances or isolation stress. Serum @entity5 level was significantly elevated by isolation stress. High-fat feeding of offspring reduced their serum @entity5 level, which was significantly elevated by a maternal @entity4 . A maternal @entity4 and isolation stress had combined effects in elevating the serum @entity5 level. These findings suggest that a maternal @entity4 during lactation enhances the stress sensitivity of offspring. White adipose tissue weights were significantly increased by a maternal @entity4 and isolation stress and by their combination. In addition, significant adipocyte @entity3 was induced by a maternal @entity4 and isolation stress and exacerbated by their combination. Thus, a maternal @entity4 and isolation stress promote visceral fat accumulation and adipocyte @entity3 , accelerating the progression of @entity1 through their combined effects. The mechanism may involve enhanced @entity2 synthesis and lipid influx from blood into adipose tissue. These findings demonstrate that a maternal @entity4 during lactation may increase the susceptibility of offspring to the development of stress-induced @entity1 .

title: High Dietary Fat Intake during Lactation Promotes the Development of Social Stress-Induced @entity1 in the Offspring of XXXX .

answer: @entity0


abstract: UNASSIGNED: This study investigated whether @entity4 ( @entity4 ) was associated with the presence of @entity0 herpes virus ( @entity2 B in @entity3 ( @entity3 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity4 polymorphism in 46 @entity0 with @entity3 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity2 B DNA and immunohistochemistry (IHC) for @entity2 B protein. Viral DNA load was significantly increased in @entity3 @entity0 with @entity2 B(+)/ @entity4 compared with those with @entity2 B(+)/non- @entity4 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity2 B proteins G116/64/54, P98 and U94 in @entity0 with @entity2 B(+)/ @entity4 than @entity2 B(+)/non- @entity4 (p=0.009, 0.035 and 0.009, respectively). @entity0 with @entity2 B(+)/ @entity4 showed higher @entity1 frequency than those with @entity2 B(+)/non- @entity4 (p=0.005). There was no significant difference of @entity4 alleles between @entity3 with and without @entity2 B (p=0.115). @entity4 was not associated with initial infection of @entity2 B in @entity3 . However, @entity4 may facilitate @entity2 B reactivation, DNA replication, virus protein expression and increase @entity1 frequency in @entity3 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity4 and @entity2 B.

title: @entity4 may increase viral load and XXXX frequency in @entity3 @entity0 with positive @entity0 herpes virus 6B.

answer: @entity1


abstract: UNASSIGNED: This study investigated whether @entity4 ( @entity4 ) was associated with the presence of @entity0 herpes virus ( @entity2 B in @entity3 ( @entity3 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity4 polymorphism in 46 @entity0 with @entity3 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity2 B DNA and immunohistochemistry (IHC) for @entity2 B protein. Viral DNA load was significantly increased in @entity3 @entity0 with @entity2 B(+)/ @entity4 compared with those with @entity2 B(+)/non- @entity4 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity2 B proteins G116/64/54, P98 and U94 in @entity0 with @entity2 B(+)/ @entity4 than @entity2 B(+)/non- @entity4 (p=0.009, 0.035 and 0.009, respectively). @entity0 with @entity2 B(+)/ @entity4 showed higher @entity1 frequency than those with @entity2 B(+)/non- @entity4 (p=0.005). There was no significant difference of @entity4 alleles between @entity3 with and without @entity2 B (p=0.115). @entity4 was not associated with initial infection of @entity2 B in @entity3 . However, @entity4 may facilitate @entity2 B reactivation, DNA replication, virus protein expression and increase @entity1 frequency in @entity3 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity4 and @entity2 B.

title: @entity4 may increase viral load and @entity1 frequency in XXXX @entity0 with positive @entity0 herpes virus 6B.

answer: @entity3


abstract: UNASSIGNED: This study investigated whether @entity4 ( @entity4 ) was associated with the presence of @entity0 herpes virus ( @entity2 B in @entity3 ( @entity3 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity4 polymorphism in 46 @entity0 with @entity3 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity2 B DNA and immunohistochemistry (IHC) for @entity2 B protein. Viral DNA load was significantly increased in @entity3 @entity0 with @entity2 B(+)/ @entity4 compared with those with @entity2 B(+)/non- @entity4 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity2 B proteins G116/64/54, P98 and U94 in @entity0 with @entity2 B(+)/ @entity4 than @entity2 B(+)/non- @entity4 (p=0.009, 0.035 and 0.009, respectively). @entity0 with @entity2 B(+)/ @entity4 showed higher @entity1 frequency than those with @entity2 B(+)/non- @entity4 (p=0.005). There was no significant difference of @entity4 alleles between @entity3 with and without @entity2 B (p=0.115). @entity4 was not associated with initial infection of @entity2 B in @entity3 . However, @entity4 may facilitate @entity2 B reactivation, DNA replication, virus protein expression and increase @entity1 frequency in @entity3 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity4 and @entity2 B.

title: XXXX may increase viral load and @entity1 frequency in @entity3 @entity0 with positive @entity0 herpes virus 6B.

answer: @entity4


abstract: UNASSIGNED: This study investigated whether @entity4 ( @entity4 ) was associated with the presence of @entity0 herpes virus ( @entity2 B in @entity3 ( @entity3 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity4 polymorphism in 46 @entity0 with @entity3 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity2 B DNA and immunohistochemistry (IHC) for @entity2 B protein. Viral DNA load was significantly increased in @entity3 @entity0 with @entity2 B(+)/ @entity4 compared with those with @entity2 B(+)/non- @entity4 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity2 B proteins G116/64/54, P98 and U94 in @entity0 with @entity2 B(+)/ @entity4 than @entity2 B(+)/non- @entity4 (p=0.009, 0.035 and 0.009, respectively). @entity0 with @entity2 B(+)/ @entity4 showed higher @entity1 frequency than those with @entity2 B(+)/non- @entity4 (p=0.005). There was no significant difference of @entity4 alleles between @entity3 with and without @entity2 B (p=0.115). @entity4 was not associated with initial infection of @entity2 B in @entity3 . However, @entity4 may facilitate @entity2 B reactivation, DNA replication, virus protein expression and increase @entity1 frequency in @entity3 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity4 and @entity2 B.

title: @entity4 may increase viral load and @entity1 frequency in @entity3 XXXX with positive @entity0 herpes virus 6B.

answer: @entity0


abstract: UNASSIGNED: This study investigated whether @entity4 ( @entity4 ) was associated with the presence of @entity0 herpes virus ( @entity2 B in @entity3 ( @entity3 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity4 polymorphism in 46 @entity0 with @entity3 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity2 B DNA and immunohistochemistry (IHC) for @entity2 B protein. Viral DNA load was significantly increased in @entity3 @entity0 with @entity2 B(+)/ @entity4 compared with those with @entity2 B(+)/non- @entity4 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity2 B proteins G116/64/54, P98 and U94 in @entity0 with @entity2 B(+)/ @entity4 than @entity2 B(+)/non- @entity4 (p=0.009, 0.035 and 0.009, respectively). @entity0 with @entity2 B(+)/ @entity4 showed higher @entity1 frequency than those with @entity2 B(+)/non- @entity4 (p=0.005). There was no significant difference of @entity4 alleles between @entity3 with and without @entity2 B (p=0.115). @entity4 was not associated with initial infection of @entity2 B in @entity3 . However, @entity4 may facilitate @entity2 B reactivation, DNA replication, virus protein expression and increase @entity1 frequency in @entity3 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity4 and @entity2 B.

title: @entity4 may increase viral load and @entity1 frequency in @entity3 @entity0 with positive XXXX herpes virus 6B.

answer: @entity0