abstract: OBJECTIVES: Direct injury to the corticospinal tract (CST) is a major factor defining @entity2 after @entity1 . Diffusion tensor imaging (DTI) tractography allows definition of the CST. We sought to determine whether DTI-based assessment of the degree of CST damage correlates with @entity2 at each phase of @entity3 . METHODS: We evaluated @entity0 at the acute (3-7 days), subacute (30 days), and chronic (90 days) phases of @entity3 with DTI and clinical motor scores (upper extremity Fugl-Myer test [UE-FM], motor items of the National Institutes of Health @entity1 Scale [mNIHSS]). The CST was identified and virtual fiber numbers (FN) were calculated for the affected and contralateral CST. We used Spearman correlation to study the relationship of FN ratio (FNr) (affected/unaffected CST) with motor scores at each time point, and the regression model to study the association of the acute parameters with chronic motor scores. RESULTS: We studied 23 @entity0 . Mean age was 66.7 (  12) years. FNr correlated with UE-FM score in the acute (r = 0.50, P = 0.032), subacute (r = 0.57, P = 0.007), and chronic (r = 0.67, P = 0.0008) phase, and with mNIHSS in the acute (r = -0.48, P = 0.043), subacute (r = -0.58, P = 0.006), and chronic (r = -0.75, P = 0.0001) phase. The combination of acute NIHSS and FNr significantly predicted chronic UE-FM score (r = 0.74, P = 0.0001). INTERPRETATION: DTI-defined degree of CST injury correlates with @entity2 at each phase of @entity3 . The combination of baseline FNr and NIHSS predicts motor outcome. DTI-derived CST assessment could become a surrogate marker of @entity2 in the design of neurorestorative clinical trials.

title: Degree of corticospinal tract damage correlates with motor function after XXXX .

answer: @entity1


abstract: PURPOSE: The effect of the sensitizer @entity4 was prospectively evaluated in recurrent @entity2 . Endpoints of the study were mainly local response rates and survival. METHODS AND MATERIALS: From 1984 to 1990 @entity4 was given together with radiation therapy to 40 @entity0 with recurrent inoperable @entity2 . Loco-regional relapses in the pelvis were isolated in 24 and associated with distant @entity1 in 16 @entity0 . Special attention was given to the subset of 24 @entity0 with isolated local recurrences. This group was compared with historical controls treated with radiotherapy alone. The dosage of @entity4 was 150 mg/m2 daily orally starting 5 days before the first irradiation. The drug was then given each radiation day until the end of treatment. The median radiation dose was 60 (40-62) Gy in the evaluable @entity0 . The minimum follow-up was 32 months and the median 72 months. RESULTS: The rates of complete plus partial responses were 57% and 54%, respectively, for recurrent @entity0 without and with distant @entity1 . The 23 evaluable @entity0 with isolated local relapses had a median survival of 24 months (12-94+); all @entity0 surviving at least 1 year. CONCLUSION: The combination of radiotherapy and @entity4 may lead to better local control and improved median survival compared to our historical controls and literature reports where radiotherapy alone was used. The treatment is easy to administer and is associated with a moderate @entity3 .

title: Inoperable recurrent @entity2 : results of a prospective trial with radiation therapy and XXXX .

answer: @entity4


abstract: PURPOSE: The effect of the sensitizer @entity4 was prospectively evaluated in recurrent @entity2 . Endpoints of the study were mainly local response rates and survival. METHODS AND MATERIALS: From 1984 to 1990 @entity4 was given together with radiation therapy to 40 @entity0 with recurrent inoperable @entity2 . Loco-regional relapses in the pelvis were isolated in 24 and associated with distant @entity1 in 16 @entity0 . Special attention was given to the subset of 24 @entity0 with isolated local recurrences. This group was compared with historical controls treated with radiotherapy alone. The dosage of @entity4 was 150 mg/m2 daily orally starting 5 days before the first irradiation. The drug was then given each radiation day until the end of treatment. The median radiation dose was 60 (40-62) Gy in the evaluable @entity0 . The minimum follow-up was 32 months and the median 72 months. RESULTS: The rates of complete plus partial responses were 57% and 54%, respectively, for recurrent @entity0 without and with distant @entity1 . The 23 evaluable @entity0 with isolated local relapses had a median survival of 24 months (12-94+); all @entity0 surviving at least 1 year. CONCLUSION: The combination of radiotherapy and @entity4 may lead to better local control and improved median survival compared to our historical controls and literature reports where radiotherapy alone was used. The treatment is easy to administer and is associated with a moderate @entity3 .

title: Inoperable recurrent XXXX : results of a prospective trial with radiation therapy and @entity4 .

answer: @entity2


abstract: UNASSIGNED: In @entity4 , the AcuK and AcuM transcription factors form a complex that regulates gluconeogenesis. In @entity1 , AcuM governs gluconeogenesis and @entity2 acquisition in vitro, and virulence in immunosuppressed @entity0 . However, the function of AcuK was previously unknown. Through in vitro studies, we found that A. fumigatus   acuK single and   acuK   acuM double mutants had impaired gluconeogenesis and @entity2 acquisition, similar to the   acuM mutant. Also, the   acuK,   acuM, and   acuK   acuM mutants had similar virulence defects in @entity0 . However, compared to the   acuM mutant, the   acuK mutant had a milder defect in extracellular siderophore activity and induction of epithelial cell damage in vitro. Moreover, overexpression of acuM in the   acuK mutant altered expression of 3 genes and partially restored growth under @entity2 -limited conditions, suggesting that AcuM can govern some genes independently of AcuK. Although the   acuK and   acuM mutants had very similar transcriptional profiles in vitro, their transcriptional profiles during @entity0 @entity3 differed both from their in vitro profiles and from each other. While AcuK and AcuM governed the expression of only a few @entity2 responsive genes in vivo, they influenced the expression of other virulence-related genes such as @entity5 and dvrA. Therefore, in A. fumigatus, while AcuK and AcuM likely function as part of the same complex, they can also function independently of each other. Furthermore, AcuK and AcuM have different target genes in vivo as compared to in vitro, suggesting that in vivo infection stimulates unique transcriptional regulatory pathways in A. fumigatus.

title: Divergent Targets of XXXX AcuK and AcuM Transcription Factors during Growth in vitro versus Invasive Disease.

answer: @entity1


abstract: BACKGROUND: Obese and morbidly @entity1 @entity0 undergoing lumbar spinal fusion surgery are a challenge to the operating surgeon. Minimally invasive transforaminal lumbar interbody fusion ( @entity4 ) and open-TLIF have been performed for many years with good results; however, functional outcomes after lumbar spine surgery in this subgroup of @entity0 remain poorly understood. Furthermore, whether index @entity4 or open-TLIF for the treatment of @entity3 or spondylolisthesis in morbidly @entity1 results in superior postoperative functional outcomes remains unknown. METHODS: A total of 148 ( @entity4 : n  = 40, open-TLIF: n  = 108) @entity1 and morbidly @entity1 @entity0 undergoing index lumbar arthrodesis for @entity9 and/or @entity6 between January 2003 and December 2010 were selected from a multi-institutional prospective data registry. We collected and analyzed data on @entity0 demographics, @entity5 , @entity7 , @entity2 , and functional disability over 2 years. @entity0 completed the @entity8 Index (ODI), Medical Outcomes Study Short-Form 36 (SF-36), and back and @entity2 numerical rating scores before surgery and then at 12 and 24 months after surgery. Clinical outcomes and complication rates were compared between both @entity0 cohorts. RESULTS: Compared with preoperative status, Visual Analog Scale (VAS) back and @entity2 , ODI, and SF-36 physical component score/mental component score were improved in both groups. Both @entity4 and open-TLIF @entity0 showed similar 2-year improvement in VAS for @entity7 ( @entity4 : 2.42    3.81 vs. open-TLIF: 2.33    3.67, P  = 0.89), VAS for @entity2 ( @entity4 : 3.77    4.53 vs. open-TLIF: 2.67    4.10, P  = 0.18), ODI ( @entity4 : 11.61    25.52 vs. open-TLIF: 14.88    22.07, P  = 0.47), and SF-36 physical component score ( @entity4 : 8.61    17.72 vs. open-TLIF: 7.61    15.55, P  = 0.93), and SF-36 mental component score ( @entity4 : 4.35    22.71 vs. open-TLIF: 5.96    21.09, P  = 0.69). @entity5 rates between both cohorts were also not significantly divergent between (12.50% vs. 11.11%, P  = 0.51). CONCLUSION: @entity4 is a safe and viable option for lumbar fusion in morbidly @entity1 @entity0 and, compared with open-TLIF, resulted in similar improvement in @entity2 . @entity5 rates between both cohorts were also not significantly divergent.

title: A prospective, multi-institutional comparative effectiveness study of lumbar spine surgery in morbidly XXXX @entity0 : does minimally invasive transforaminal lumbar interbody fusion result in superior outcomes?

answer: @entity1


abstract: BACKGROUND: Obese and morbidly @entity1 @entity0 undergoing lumbar spinal fusion surgery are a challenge to the operating surgeon. Minimally invasive transforaminal lumbar interbody fusion ( @entity4 ) and open-TLIF have been performed for many years with good results; however, functional outcomes after lumbar spine surgery in this subgroup of @entity0 remain poorly understood. Furthermore, whether index @entity4 or open-TLIF for the treatment of @entity3 or spondylolisthesis in morbidly @entity1 results in superior postoperative functional outcomes remains unknown. METHODS: A total of 148 ( @entity4 : n  = 40, open-TLIF: n  = 108) @entity1 and morbidly @entity1 @entity0 undergoing index lumbar arthrodesis for @entity9 and/or @entity6 between January 2003 and December 2010 were selected from a multi-institutional prospective data registry. We collected and analyzed data on @entity0 demographics, @entity5 , @entity7 , @entity2 , and functional disability over 2 years. @entity0 completed the @entity8 Index (ODI), Medical Outcomes Study Short-Form 36 (SF-36), and back and @entity2 numerical rating scores before surgery and then at 12 and 24 months after surgery. Clinical outcomes and complication rates were compared between both @entity0 cohorts. RESULTS: Compared with preoperative status, Visual Analog Scale (VAS) back and @entity2 , ODI, and SF-36 physical component score/mental component score were improved in both groups. Both @entity4 and open-TLIF @entity0 showed similar 2-year improvement in VAS for @entity7 ( @entity4 : 2.42    3.81 vs. open-TLIF: 2.33    3.67, P  = 0.89), VAS for @entity2 ( @entity4 : 3.77    4.53 vs. open-TLIF: 2.67    4.10, P  = 0.18), ODI ( @entity4 : 11.61    25.52 vs. open-TLIF: 14.88    22.07, P  = 0.47), and SF-36 physical component score ( @entity4 : 8.61    17.72 vs. open-TLIF: 7.61    15.55, P  = 0.93), and SF-36 mental component score ( @entity4 : 4.35    22.71 vs. open-TLIF: 5.96    21.09, P  = 0.69). @entity5 rates between both cohorts were also not significantly divergent between (12.50% vs. 11.11%, P  = 0.51). CONCLUSION: @entity4 is a safe and viable option for lumbar fusion in morbidly @entity1 @entity0 and, compared with open-TLIF, resulted in similar improvement in @entity2 . @entity5 rates between both cohorts were also not significantly divergent.

title: A prospective, multi-institutional comparative effectiveness study of lumbar spine surgery in morbidly @entity1 XXXX : does minimally invasive transforaminal lumbar interbody fusion result in superior outcomes?

answer: @entity0


abstract: PURPOSE: To evaluate the intraoperative modifications for and vision outcomes after implantation of glued intraocular lenses (IOLs) in eyes with @entity4 . SETTING: Dr. Agarwal's Eye Hospital and Eye Research Centre, Chennai, India. DESIGN: Prospective case series. METHODS: Eyes with a horizontal cornea of 10.0  mm or less were evaluated for intraoperative modifications and postoperative vision after implantation of a glued IOL. The type of surgery, type of IOL, incision and optic sizes, haptic length modifications, uncorrected (UDVA) and corrected (CDVA) distance visual acuity, and @entity1 were analyzed. RESULTS: A glued IOL was @entity2 to treat subluxated @entity0 (9 eyes), @entity3 (5), and intraoperative capsule loss (1). In cases involving a subluxated @entity0 , implantation of the glued IOL was followed by lensectomy (7 eyes) or intracapsular @entity0 extraction (2 eyes). The mean follow-up was 22.4 months      17.2 (SD). The mean horizontal corneal diameter and axial length were 8.0      0.6  mm and 21.0      2.4  mm, respectively. The mean amount of IOL haptic trimmed intraoperatively was 1.54      0.33  mm. There was significant correlation between the horizontal corneal diameter and the amount of haptic trimmed (P  =  .000). The mean size of the main incision was 3.70      0.98  mm. Three-piece foldable IOLs with a 6.0  mm optic were used. There were no cases of haptic extrusion or subconjunctival haptic placement. There was statistically significant improvement in CDVA (P  =  .032) and UDVA (P  =  .012) after surgery. CONCLUSION: Glued IOLs were safely implanted in eyes with @entity4 using modifications such as custom haptic trimming and 6.0 mm optic foldable IOLs. FINANCIAL DISCLOSURE: Dr. Amar Agarwal is a paid consultant to Staar Surgical Co. No other author has a financial or proprietary interest in any material or method mentioned.

title: Implantation of glued intraocular lenses in eyes with XXXX .

answer: @entity4


abstract: OBJECTIVE: To discuss the surgical methods of total knee arthroplasty (TKA) in the @entity0 with active @entity4 of the knee and find out its curative effect after TKA. @entity0 ANDMETHODS: We analyzed 10 @entity0 with active @entity4 of the knee who received TKA in our department from March 2006 to March 2010, whose ages were from 22 to 64 years old (average age was 40.6    1 years). The following parameters were measured in the pre- and post-operation periods: HSS score, range of motion (ROM). From x-ray to find out post-operate curative effect of TKA. RESULTS: All cases had @entity2 and elevated ESR. @entity5 ( @entity5 ) and @entity1 were not found in these cases. There were 4 cases that had sinuses on the skin: the skin healed before the operation took place. Pre-operation HSS average scores were 25.0    2. All @entity0 received TKA by the para-patellar medial approach. Eight cases were followed-up for 6-28 months; the average follow-up period was14    0.5 months. Post-operation we took an HSS score and X-rays to find out its curative effect after TKA operation. There were also no @entity0 with dislocation   aseptic loosening or @entity3 of prosthesis, although 1 case had recurrence. Post-operation's HSS average scores were 86.75    5.45. The average ROM was improved to 95    5  . CONCLUSIONS: Recent clinical results indicate that TKA is effective to treat the @entity0 with active @entity4 of the knee joint. TKA can significantly improve the function of the joint and relieve @entity2 , improving @entity0 ' living conditions.

title: Total knee arthroplasty treatment of active XXXX of the knee: a review of 10 cases.

answer: @entity4


abstract: UNASSIGNED: @entity1 ( @entity1 ) is a progressive @entity2 caused by mutations in the @entity3 gene. One-third of @entity1 cases are complicated by @entity0 . Here, we used reverse transcription PCR to analyze the pattern of @entity3 transcripts in neuronal SH-SY5Y cells. Among the three alternative promoters/first exons at the 5'-end, only transcripts containing the brain cortex-specific C1 exon could be amplified. The C-transcript appeared as two products: a major product of the expected size and a minor larger product that contained the cryptic exon 1a between exons @entity4 . At the 3'-end there was complete exon 78 skipping. Together, these findings indicate that SH-SY5Y cells have neuron-specific characteristics with regard to both promoter activation and alternative splicing. We also revealed partial skipping of exons 9 and 71. Four amplified products were obtained from a fragment covering exons 36-41: a strong expected product, two weak products lacking either exon 37 or exon 38, and a second strong larger product with a 568-bp insertion between exons 40 and 41. The inserted sequence matched the 3'-end of intron 40 perfectly. We concluded that a cryptic splice site was activated in SH-SY5Y cells to create the novel, unusually large, exon 41e (751  bp). In total, we identified seven alternative splicing events in neuronal SH-SY5Y cells, and calculated that 32 @entity3 transcripts could be produced. Our results may provide clues in the analysis of transcriptype-phenotype correlations as regards @entity0 in @entity1 .

title: Neuronal SH-SY5Y cells use the C- XXXX promoter coupled with exon 78 skipping and display multiple patterns of alternative splicing including two intronic insertion events.

answer: @entity3


abstract: BACKGROUND: Features of @entity2 associated with @entity1 ( @entity1 ), such as low volume, variable rate of speech and increased pauses, impact speaker intelligibility. Those affected report restricted interactional participation, although this area is under explored. AIMS: To examine naturally occurring instances of problems with intelligibility that resulted in multiple attempts at repair in order to consider repair initiation strategies that might restrict or enhance participation. METHODS _ PROCEDURES: Thirteen @entity0 with @entity1 (PwPD) video-recorded over 10 h of informal conversation data in their home setting involving familiar @entity3 ( @entity3 ). Using a conversation analytic (CA) approach, and drawing on an existing typology of repair initiators (RIs) for everyday talk-in-interaction and their relative power to locate a turn's repairable element, the design and ordering of RIs used by @entity3 was addressed, alongside their local consequences. OUTCOMES _ RESULTS: @entity3 tended to increase the specificity of their RIs in line with the existing typology, progressing from open class forms (e.g. 'mm?') to more specific forms (e.g. questions/partial repeats). Repeated open class repair initiators (OCRIs) were used where @entity1 speakers' self-repair attempts provided limited information. Sometimes, however, specificity was increased too soon, before enough syntactic knowledge was gleaned, which resulted in an extended repair sequence. Where one OCRI followed another, the second always took a different form: lexically or in terms of prosodic/non-verbal features. RI forms not described in the existing typology were also identified, such as 'prompts to modify speech' (e.g. 'Speak louder') and repeating/rephrasing the original first pair part (e.g. question), and their effectiveness examined. CONCLUSIONS _ IMPLICATIONS: First steps are presented towards the design of a communication intervention promoting the efficient resolution of repair to moderate social withdrawal and increase participation for this client group. Future research will need to explore the feasibility and acceptability of such a resource.

title: Multiple repair sequences in everyday conversations involving @entity0 with XXXX .

answer: @entity1


abstract: BACKGROUND: Features of @entity2 associated with @entity1 ( @entity1 ), such as low volume, variable rate of speech and increased pauses, impact speaker intelligibility. Those affected report restricted interactional participation, although this area is under explored. AIMS: To examine naturally occurring instances of problems with intelligibility that resulted in multiple attempts at repair in order to consider repair initiation strategies that might restrict or enhance participation. METHODS _ PROCEDURES: Thirteen @entity0 with @entity1 (PwPD) video-recorded over 10 h of informal conversation data in their home setting involving familiar @entity3 ( @entity3 ). Using a conversation analytic (CA) approach, and drawing on an existing typology of repair initiators (RIs) for everyday talk-in-interaction and their relative power to locate a turn's repairable element, the design and ordering of RIs used by @entity3 was addressed, alongside their local consequences. OUTCOMES _ RESULTS: @entity3 tended to increase the specificity of their RIs in line with the existing typology, progressing from open class forms (e.g. 'mm?') to more specific forms (e.g. questions/partial repeats). Repeated open class repair initiators (OCRIs) were used where @entity1 speakers' self-repair attempts provided limited information. Sometimes, however, specificity was increased too soon, before enough syntactic knowledge was gleaned, which resulted in an extended repair sequence. Where one OCRI followed another, the second always took a different form: lexically or in terms of prosodic/non-verbal features. RI forms not described in the existing typology were also identified, such as 'prompts to modify speech' (e.g. 'Speak louder') and repeating/rephrasing the original first pair part (e.g. question), and their effectiveness examined. CONCLUSIONS _ IMPLICATIONS: First steps are presented towards the design of a communication intervention promoting the efficient resolution of repair to moderate social withdrawal and increase participation for this client group. Future research will need to explore the feasibility and acceptability of such a resource.

title: Multiple repair sequences in everyday conversations involving XXXX with @entity1 .

answer: @entity0


abstract: BACKGROUND: The significant impact @entity1 ( @entity1 ) has on @entity0 morbidity and mortality emphasizes the need for early recognition and effective treatment. @entity1 presenting to or occurring during hospitalisation has been widely studied but little is known about the incidence and outcomes of @entity0 experiencing acute elevations in serum @entity2 in the primary care setting where @entity0 are not subsequently admitted to hospital. The aim of this study was to define this incidence and explore its impact on mortality. METHODS: The study cohort was identified by using hospital data bases over a six month period.Inclusion criteria: @entity0 with a serum @entity2 request during the study period, 18 or over and not on renal replacement therapy.The @entity0 were stratified by a rise in serum @entity2 corresponding to the @entity1 Network (AKIN) criteria for comparison purposes. Descriptive and survival data were then analysed.Ethical approval was granted from National Research Ethics Service (NRES) Committee South East Coast and from the National Information Governance Board. RESULTS: The total study population was 61,432. 57,300 subjects with 'no @entity1 ', mean age 64.The number (mean age) of acute serum @entity2 rises overall were, ' @entity1 1' 3,798 (72), ' @entity1 2' 232 (73), and ' @entity1 3' 102 (68) which equates to an overall incidence of 14,192 pmp/year (adult). Unadjusted 30 day survival was 99.9% in subjects with 'no @entity1 ', compared to 98.6%, 90.1% and 82.3% in those with ' @entity1 1', ' @entity1 2' and ' @entity1 3' respectively. After multivariable analysis adjusting for age, gender, baseline kidney function and co-morbidity the odds ratio of 30 day mortality was 5.3 (95% CI 3.6, 7.7), 36.8 (95% CI 21.6, 62.7) and 123 (95% CI 64.8, 235) respectively, compared to those without acute serum @entity2 rises as defined. CONCLUSIONS: @entity0 who develop acute elevations of serum @entity2 in primary care without being admitted to hospital have significantly worse outcomes than those with stable kidney function.

title: Do acute elevations of serum XXXX in primary care engender an increased mortality risk?

answer: @entity2


abstract: OBJECTIVE: Providing a safe and efficient dental treatment for a young @entity0 is a challenge for the dentist and the @entity0 . The purpose of this study was to investigate the effectiveness, safety and acceptability of buccal @entity2 in dental pediatric @entity0 and to compare it with oral @entity2 . METHODS: Eighteen uncooperative healthy @entity0 aged 2.5-6 years were randomized to each of buccal @entity2 (0.3mg/kg) or oral @entity2 (0.5mg/kg) at the first visit, the alternative has been used at the second visit in a cross-over manner. The study took place at pediatric dentistry clinic of Shahed University, Tehran, from November 2011 to June 2012. The @entity0 ' vital signs and behavioral scores were recorded. The @entity0 , the operator and the observer were blinded to the applied medication. Post operatively, @entity0 ' and parents' satisfaction were assessed by Visual Analogue Score and a questionnaire respectively. The P-value was set at 0.05 for significance level. FINDINGS: There were no significant differences in physiologic factors in the medication groups at time 0, 10, 20, 30 minutes and discharge. There was also no significant difference between the two groups in behavioral parameters. The majority of parents rated both sedative agents as "effective" or "very effective" and their @entity0 mostly were without @entity1 or with minor @entity1 . CONCLUSION: Buccal @entity2 may be safely and efficiently used in sedation of pediatric dental @entity0 .

title: Comparison of Oral and Buccal XXXX for Pediatric Dental Sedation: A Randomized, Cross-Over, Clinical Trial for Efficacy, Acceptance and Safety.

answer: @entity2


abstract: Medical therapy for @entity5 due to bilateral @entity7 (BMAH) is generally administered for a limited time before surgery. Aberrant receptors antagonists show inconsistent efficacy in the long run to prevent adrenalectomy. We present a @entity0 with BMAH, treated for 10 years with low doses of @entity12 to control @entity6 secretion. A 48-year-old @entity0 presented with @entity2 and @entity3 . Investigations showed the following: no clinical signs of @entity5 ; enlarged lobulated adrenals; normal @entity10 , @entity9 , and @entity11 ; normal urinary @entity11 and metanephrines; elevated urinary free @entity6 and @entity4 metabolites; and suppressed plasma @entity8 activity and ACTH. A screening protocol for aberrant adrenal receptors failed to show any illegitimate hormone dependence. @entity12 caused rapid normalisation of @entity6 and ACTH that persists over 10 years on treatment, while adrenals show no change in shape or size. @entity12 decreases @entity6 in @entity0 with @entity5 , and may prevent @entity7 . @entity4 secretion in BMAH is inefficient as compared with normal adrenals or secreting @entity1 and can be controlled with low, well-tolerated doses of @entity12 , as an alternative to surgery. LEARNING POINTS: Enlarged, macronodular adrenals are often incidentally found during the investigation of @entity3 in @entity0 harboring BMAH. Although laboratory findings include low ACTH and elevated @entity6 , the majority of @entity0 do not display cushingoid features.Bilateral adrenalectomy, followed by life-long @entity4 replacement, is the usual treatment of this benign condition, and alternative medical therapy is sought. Therapy based on aberrant adrenal receptors gives disappointing results, and inhibitors of steroidogenesis are not always well tolerated.However, @entity12 at low, well-tolerated doses appeared appropriate to control adrenal @entity4 secretion indefinitely, while preventing @entity7 . This treatment probably constitutes the most convenient long-term alternative to surgery.

title: Long-term low-dose XXXX treatment in bilateral @entity7 .

answer: @entity12


abstract: Medical therapy for @entity5 due to bilateral @entity7 (BMAH) is generally administered for a limited time before surgery. Aberrant receptors antagonists show inconsistent efficacy in the long run to prevent adrenalectomy. We present a @entity0 with BMAH, treated for 10 years with low doses of @entity12 to control @entity6 secretion. A 48-year-old @entity0 presented with @entity2 and @entity3 . Investigations showed the following: no clinical signs of @entity5 ; enlarged lobulated adrenals; normal @entity10 , @entity9 , and @entity11 ; normal urinary @entity11 and metanephrines; elevated urinary free @entity6 and @entity4 metabolites; and suppressed plasma @entity8 activity and ACTH. A screening protocol for aberrant adrenal receptors failed to show any illegitimate hormone dependence. @entity12 caused rapid normalisation of @entity6 and ACTH that persists over 10 years on treatment, while adrenals show no change in shape or size. @entity12 decreases @entity6 in @entity0 with @entity5 , and may prevent @entity7 . @entity4 secretion in BMAH is inefficient as compared with normal adrenals or secreting @entity1 and can be controlled with low, well-tolerated doses of @entity12 , as an alternative to surgery. LEARNING POINTS: Enlarged, macronodular adrenals are often incidentally found during the investigation of @entity3 in @entity0 harboring BMAH. Although laboratory findings include low ACTH and elevated @entity6 , the majority of @entity0 do not display cushingoid features.Bilateral adrenalectomy, followed by life-long @entity4 replacement, is the usual treatment of this benign condition, and alternative medical therapy is sought. Therapy based on aberrant adrenal receptors gives disappointing results, and inhibitors of steroidogenesis are not always well tolerated.However, @entity12 at low, well-tolerated doses appeared appropriate to control adrenal @entity4 secretion indefinitely, while preventing @entity7 . This treatment probably constitutes the most convenient long-term alternative to surgery.

title: Long-term low-dose @entity12 treatment in bilateral XXXX .

answer: @entity7


abstract: To discriminate @entity3 from atypical @entity1 /well-differentiated @entity4 (ALT/WDL) we perform fluorescence in situ hybridization (FISH) for @entity5 amplification in several problematic situations: " @entity3 " >10 cm, lesions with equivocal atypia, recurrent " @entity3 ," all @entity3 ", and in cases not fitting the above criteria but having worrisome clinical or radiologic features. To ascertain the validity of these criteria, we have reviewed our experience with 301 consecutive differentiated @entity1 in which the diagnosis of ALT could not be established on the basis of histologic sections and in which FISH was performed on the basis of the above criteria. The final diagnosis was based on @entity5 amplification status. Given the nature of this study to evaluate difficult lesions, most cases included (74%) were received in consultation. This enhanced our study series for borderline cases, and the data presented may not be generalizable to adipocytic @entity1 seen outside a subspecialty setting. Of 301 cases, 108 proved to be ALT/WDL (36%). The most common test indication was size >10 cm (n=187), followed by equivocal atypia (n=145), retroperitoneal/pelvic/abdominal location (n=86), recurrence (n=33), and clinical concern (n=12). Of the @entity1 >10 cm, 68 (36%) proved to be ALT/WDL, whereas the remainder were interpreted as @entity3 or its variants (eg, spindle cell or @entity3 ). The 2 groups did not differ statistically in size, although ALTs consistently occurred in @entity0 above 50 years of age. Of the cases with equivocal atypia, 72 (50%) proved to be ALT/WDL. Those in the retroperitoneum/abdomen/pelvis were ALT/WDL in 30 cases (35%), and those that had recurred were ALT in 18 cases (55%). Recurrence, atypia, and having multiple indications for testing were more common in ALT than in benign lesions (P=0.02, 0.0001, 0.0012, respectively). No ALT/WDL occurred in the hands and feet, and only a single ALT/WDL was superficial (1 ALT/WDL vs. 60 @entity3 /spindle cell or @entity3 ). Small (<10 cm) @entity1 without additional features were always benign (n=9). On the basis of our results, FISH testing is recommended for: (1) recurrent lesions; (2) @entity2 that are >10 cm in @entity0 over 50 years of age; (3) in cases with equivocal atypia; (4) in lesions of the retroperitoneum/pelvis/abdomen, and in special clinical situations as directed by treating clinicians. Testing is low yield in superficial lesions, in small extremity lesions without additional indicators for testing, in large extremity lesions without additional features in @entity0 under the age of 50, and in lesions arising in the hands/feet. More evidence is needed regarding testing in @entity2 without additional features. By adopting these criteria, we could have avoided testing 74 cases, missing a single superficial ALT/WDL.

title: XXXX Amplification in Problematic @entity1 : Analysis of FISH Testing Criteria.

answer: @entity5


abstract: To discriminate @entity3 from atypical @entity1 /well-differentiated @entity4 (ALT/WDL) we perform fluorescence in situ hybridization (FISH) for @entity5 amplification in several problematic situations: " @entity3 " >10 cm, lesions with equivocal atypia, recurrent " @entity3 ," all @entity3 ", and in cases not fitting the above criteria but having worrisome clinical or radiologic features. To ascertain the validity of these criteria, we have reviewed our experience with 301 consecutive differentiated @entity1 in which the diagnosis of ALT could not be established on the basis of histologic sections and in which FISH was performed on the basis of the above criteria. The final diagnosis was based on @entity5 amplification status. Given the nature of this study to evaluate difficult lesions, most cases included (74%) were received in consultation. This enhanced our study series for borderline cases, and the data presented may not be generalizable to adipocytic @entity1 seen outside a subspecialty setting. Of 301 cases, 108 proved to be ALT/WDL (36%). The most common test indication was size >10 cm (n=187), followed by equivocal atypia (n=145), retroperitoneal/pelvic/abdominal location (n=86), recurrence (n=33), and clinical concern (n=12). Of the @entity1 >10 cm, 68 (36%) proved to be ALT/WDL, whereas the remainder were interpreted as @entity3 or its variants (eg, spindle cell or @entity3 ). The 2 groups did not differ statistically in size, although ALTs consistently occurred in @entity0 above 50 years of age. Of the cases with equivocal atypia, 72 (50%) proved to be ALT/WDL. Those in the retroperitoneum/abdomen/pelvis were ALT/WDL in 30 cases (35%), and those that had recurred were ALT in 18 cases (55%). Recurrence, atypia, and having multiple indications for testing were more common in ALT than in benign lesions (P=0.02, 0.0001, 0.0012, respectively). No ALT/WDL occurred in the hands and feet, and only a single ALT/WDL was superficial (1 ALT/WDL vs. 60 @entity3 /spindle cell or @entity3 ). Small (<10 cm) @entity1 without additional features were always benign (n=9). On the basis of our results, FISH testing is recommended for: (1) recurrent lesions; (2) @entity2 that are >10 cm in @entity0 over 50 years of age; (3) in cases with equivocal atypia; (4) in lesions of the retroperitoneum/pelvis/abdomen, and in special clinical situations as directed by treating clinicians. Testing is low yield in superficial lesions, in small extremity lesions without additional indicators for testing, in large extremity lesions without additional features in @entity0 under the age of 50, and in lesions arising in the hands/feet. More evidence is needed regarding testing in @entity2 without additional features. By adopting these criteria, we could have avoided testing 74 cases, missing a single superficial ALT/WDL.

title: @entity5 Amplification in Problematic XXXX : Analysis of FISH Testing Criteria.

answer: @entity1


abstract: Mesenchymal stromal cells (MSCs) support the growth and differentiation of normal hematopoietic stem cells (HSCs). Here we studied the ability of MSCs to support the growth and survival of leukemic stem cells (LSCs) in vitro. Primary @entity2 isolated from the peripheral blood of 8 @entity0 with @entity4 ( @entity4 ) were co-cultured with equal numbers of irradiated MSCs derived from unrelated donor bone marrow, with or without cytokines for up to 6weeks. Four samples showed @entity3 (+) @entity5 (-) predominance, and four were predominantly @entity3 (+) @entity5 (+). @entity3 (+) @entity5 (-) predominant @entity2 cells maintained the @entity3 (+) @entity5 (-) phenotype and were viable for 6weeks when co-cultured with MSCs compared to co-cultures with cytokines or medium only, which showed rapid differentiation and loss of the LSC phenotype. In contrast, @entity3 (+) @entity5 (+) predominant leukemic cells maintained the @entity3 (+) @entity5 (+) phenotype when co-cultured with MSCs alone, but no culture conditions supported survival beyond 4weeks. Cell cycle analysis showed that MSCs maintained a higher proportion of @entity3 (+) blasts in G0 than leukemic cells cultured with cytokines. @entity4 blasts maintained in culture with MSCs for up to 6weeks engrafted NSG @entity1 with the same efficiency as their non-cultured counterparts, and the original karyotype persisted after co-culture. Chemosensitivity and transwell assays suggest that MSCs provide pro-survival benefits to @entity2 through cell-cell contact. We conclude that MSCs support long-term maintenance of LSCs in vitro. This simple and inexpensive approach will facilitate basic investigation of LSCs and enable screening of novel therapeutic agents targeting LSCs.

title: Long term maintenance of myeloid leukemic stem cells cultured with unrelated XXXX mesenchymal stromal cells.

answer: @entity0


abstract: OBJECTIVE: Cognitive slowing is a core neuropsychological symptom of @entity1 ( @entity1 ). We aimed to assess the extent to which @entity2 in @entity1 was predicted by changes in dorsolateral prefrontal networks. METHOD: We assessed @entity0 with relapsing-remitting @entity1 and healthy controls (HCs) on measures of processing speed. @entity0 underwent a functional MRI while performing a processing speed task to allow assessment of task-based connectivity. RESULTS: @entity0 were slower than HCs on the processing speed tasks. @entity0 showed attenuated connectivity between right and left dorsolateral prefrontal cortex (DLPFC) and task-relevant brain regions compared to HCs during processing speed task performance. @entity0 ' connectivity with DLPFC in these group-disparate networks accounted for significant variability in their performance on processing speed measures administered both in and out of the imaging environment. Specifically, @entity0 who had stronger functional connections with DLPFC in group-disparate networks performed faster than @entity0 with weaker connections with DLPFC in group-disparate networks. CONCLUSION: Results suggest that @entity1 -related @entity2 can be accounted for by systemic alterations in executive functional networks. (PsycINFO Database Record

title: Asynchrony in executive networks predicts @entity2 in XXXX .

answer: @entity1


abstract: OBJECTIVE: Cognitive slowing is a core neuropsychological symptom of @entity1 ( @entity1 ). We aimed to assess the extent to which @entity2 in @entity1 was predicted by changes in dorsolateral prefrontal networks. METHOD: We assessed @entity0 with relapsing-remitting @entity1 and healthy controls (HCs) on measures of processing speed. @entity0 underwent a functional MRI while performing a processing speed task to allow assessment of task-based connectivity. RESULTS: @entity0 were slower than HCs on the processing speed tasks. @entity0 showed attenuated connectivity between right and left dorsolateral prefrontal cortex (DLPFC) and task-relevant brain regions compared to HCs during processing speed task performance. @entity0 ' connectivity with DLPFC in these group-disparate networks accounted for significant variability in their performance on processing speed measures administered both in and out of the imaging environment. Specifically, @entity0 who had stronger functional connections with DLPFC in group-disparate networks performed faster than @entity0 with weaker connections with DLPFC in group-disparate networks. CONCLUSION: Results suggest that @entity1 -related @entity2 can be accounted for by systemic alterations in executive functional networks. (PsycINFO Database Record

title: Asynchrony in executive networks predicts XXXX in @entity1 .

answer: @entity2


abstract: BACKGROUND: Insufficient production oferythropoietin ( @entity5 ) is the primary cause ofanemia in @entity0 with @entity4 ( @entity4 ). The @entity5 treatment is an established treatment for @entity1 . The study investigated the therapeutic outcome between lyophilized powder and liquid form of @entity5 alpha by intravenous (IV) administration in hemoglobin maintenance of anemic treatment for @entity4 @entity0 receiving hemodialysis. MATERIAL AND METHOD: Forty @entity0 were randomly assigned to either lyophilized powder of @entity5 alpha (treatment, n = 21) or liquidform of @entity5 alpha (control, n = 19) for 12 weeks by lVadministration. The hemoglobin was maintained within the target range of 10. 0 to 12.0 g/dL by adjusting the dosage of @entity5 . The clinical and biochemical profiles including @entity2 saturation andferritin were measured. Adverse events were documented. RESULTS: The mean hemoglobin ofboth groups at baseline was 11.2  0.6 g/dL. Mean hemoglobin and mean hematocrit levels at baseline, and follow-up data of both groups were not statistically different. The mean weekly dosage of @entity5 in the treatment and control groups had no statistical significance within the same group and between groups as well. Stable hemoglobin levels were maintained without @entity5 dosage adjustment in the majority ofpatients in both groups (treatment group, 90.5%, control group, 94.7%). During the 12-week study period, no serious side effect was detected CONCLUSION: The present study demonstrated that the lyophilizedpowder ofEPO alpha was effective and safe as the standard liquid form of @entity5 alpha when it was administered by IV route in hemoglobin maintenance of @entity3 treatment.

title: A comparative study of efficacy and safety of the lyophilized powder alpha-erythropoietin and the liquid form alpha-erythropoietin for hemoglobin maintenance in XXXX with hemodialysis treatment.

answer: @entity0


abstract: @entity6 (HSA)/ @entity6 is a cell surface molecule expressed by many cell types in the @entity0 . The molecule has an unusual structure because of its small protein core and extensive glycosylation. In order to study the functional role of the HSA-associated glycoconjugates we have isolated different forms of HSA. Using lectin analysis we provide evidence for extensive heterogeneity in @entity2 composition and @entity3 linkage. Several HSA forms were recognized by @entity0 P-selectin-IgG but not E-selectin-IgG in ELISA. As expected, P-selectin-IgG also bound to L2/ @entity7 -positive neural glycoproteins (L2-glycoproteins) and @entity4 but not to gangliosides and other control glycoproteins. The binding of P-selectin-IgG to L2-glycoproteins and HSA required bivalent cations. The reactivity to HSA was sensitive to sialidase treatment whereas the binding to L2-glycoproteins was not. Studies with alpha 2-6 sialytransferase indicated that alpha 2-6 linked @entity3 was not involved in the P-selectin binding to HSA. Surprisingly, an L2/ @entity7 specific antibody was found to cross-react with some HSA glycoforms and its binding correlated with P-selectin-IgG reactivity. L2/ @entity7 -positive or L2/ @entity7 -negative HSA glycoforms were also analyzed after coating to @entity1 beads. Only the L2/ @entity7 -positive HSA coated beads were reactive with P-selectin-IgG and could bind to activated @entity5 endothelioma cells expressing P-selectin whereas the L2/ @entity7 -negative HSA beads did not. It is suggested that in its L2/ @entity7 modified form the HSA molecule on leukocytes could represent a ligand for P-selectin on endothelial cells or platelets.

title: XXXX ( @entity6 ) as ligand for @entity0 P-selectin.

answer: @entity6


abstract: @entity6 (HSA)/ @entity6 is a cell surface molecule expressed by many cell types in the @entity0 . The molecule has an unusual structure because of its small protein core and extensive glycosylation. In order to study the functional role of the HSA-associated glycoconjugates we have isolated different forms of HSA. Using lectin analysis we provide evidence for extensive heterogeneity in @entity2 composition and @entity3 linkage. Several HSA forms were recognized by @entity0 P-selectin-IgG but not E-selectin-IgG in ELISA. As expected, P-selectin-IgG also bound to L2/ @entity7 -positive neural glycoproteins (L2-glycoproteins) and @entity4 but not to gangliosides and other control glycoproteins. The binding of P-selectin-IgG to L2-glycoproteins and HSA required bivalent cations. The reactivity to HSA was sensitive to sialidase treatment whereas the binding to L2-glycoproteins was not. Studies with alpha 2-6 sialytransferase indicated that alpha 2-6 linked @entity3 was not involved in the P-selectin binding to HSA. Surprisingly, an L2/ @entity7 specific antibody was found to cross-react with some HSA glycoforms and its binding correlated with P-selectin-IgG reactivity. L2/ @entity7 -positive or L2/ @entity7 -negative HSA glycoforms were also analyzed after coating to @entity1 beads. Only the L2/ @entity7 -positive HSA coated beads were reactive with P-selectin-IgG and could bind to activated @entity5 endothelioma cells expressing P-selectin whereas the L2/ @entity7 -negative HSA beads did not. It is suggested that in its L2/ @entity7 modified form the HSA molecule on leukocytes could represent a ligand for P-selectin on endothelial cells or platelets.

title: @entity6 ( XXXX ) as ligand for @entity0 P-selectin.

answer: @entity6


abstract: @entity6 (HSA)/ @entity6 is a cell surface molecule expressed by many cell types in the @entity0 . The molecule has an unusual structure because of its small protein core and extensive glycosylation. In order to study the functional role of the HSA-associated glycoconjugates we have isolated different forms of HSA. Using lectin analysis we provide evidence for extensive heterogeneity in @entity2 composition and @entity3 linkage. Several HSA forms were recognized by @entity0 P-selectin-IgG but not E-selectin-IgG in ELISA. As expected, P-selectin-IgG also bound to L2/ @entity7 -positive neural glycoproteins (L2-glycoproteins) and @entity4 but not to gangliosides and other control glycoproteins. The binding of P-selectin-IgG to L2-glycoproteins and HSA required bivalent cations. The reactivity to HSA was sensitive to sialidase treatment whereas the binding to L2-glycoproteins was not. Studies with alpha 2-6 sialytransferase indicated that alpha 2-6 linked @entity3 was not involved in the P-selectin binding to HSA. Surprisingly, an L2/ @entity7 specific antibody was found to cross-react with some HSA glycoforms and its binding correlated with P-selectin-IgG reactivity. L2/ @entity7 -positive or L2/ @entity7 -negative HSA glycoforms were also analyzed after coating to @entity1 beads. Only the L2/ @entity7 -positive HSA coated beads were reactive with P-selectin-IgG and could bind to activated @entity5 endothelioma cells expressing P-selectin whereas the L2/ @entity7 -negative HSA beads did not. It is suggested that in its L2/ @entity7 modified form the HSA molecule on leukocytes could represent a ligand for P-selectin on endothelial cells or platelets.

title: @entity6 ( @entity6 ) as ligand for XXXX P-selectin.

answer: @entity0


abstract: OBJECTIVE: To evaluate the efficacy, complications, and managements of the readjustable midurethral sling (Remeex system) for the treatment of recurrent stress @entity2 (SUI) after previous anti- @entity2 surgeries or @entity3 ( @entity3 ). METHODS: Between March 2008 and February 2012, 102 @entity0 , who presented with previous failed surgery or @entity3 , were treated with the Remeex system at 4 different institutions. We retrospectively reviewed medical history, physical examination, urodynamic study, postvoiding residual volume, and/or 1-hour pad test of the @entity0 . Surgical outcomes were evaluated using the Severity Index for @entity2 . The degree of @entity0 satisfaction was assessed, and all complications were classified according to the modified Clavien classification system. RESULTS: After a mean follow-up of 27.6  months (range, 14-56 months), 91 @entity0 (89.2%) were cured and 6 @entity0 (5.9%) were improved. The @entity0 's satisfaction rate was 87.2% (89 of 102 @entity0 ). Overall, 41 @entity0 (40.2%) experienced 53 complications; 15 @entity0 (14.7%) presented de novo urgency, which was properly managed with anticholinergics, and 14 @entity0 (13.7%) underwent delayed sling readjustment for recurrent SUI (n  = 13) and urinary retention (n  = 1) during follow-up. Among 6 @entity0 (5.9%) with wound @entity1 , 4 @entity0 were successfully treated by daily dressing with antibiotics, and 2 @entity0 underwent removal of the Remeex system owing to intractable @entity1 . Most complications were classified as grade 1 (54.8%) or 2 (15.1%) and were successfully treated with minimal conservative measures. CONCLUSION: The Remeex system is a valuable adjunct for recurrent SUI after previous anti- @entity2 surgeries or @entity3 , considering most complications are Clavien grade I or II.

title: Midterm Efficacy and Complications of  Readjustable Midurethral Sling (Remeex System) in Female Stress @entity2 With Recurrence or  XXXX .

answer: @entity3


abstract: OBJECTIVE: To evaluate the efficacy, complications, and managements of the readjustable midurethral sling (Remeex system) for the treatment of recurrent stress @entity2 (SUI) after previous anti- @entity2 surgeries or @entity3 ( @entity3 ). METHODS: Between March 2008 and February 2012, 102 @entity0 , who presented with previous failed surgery or @entity3 , were treated with the Remeex system at 4 different institutions. We retrospectively reviewed medical history, physical examination, urodynamic study, postvoiding residual volume, and/or 1-hour pad test of the @entity0 . Surgical outcomes were evaluated using the Severity Index for @entity2 . The degree of @entity0 satisfaction was assessed, and all complications were classified according to the modified Clavien classification system. RESULTS: After a mean follow-up of 27.6  months (range, 14-56 months), 91 @entity0 (89.2%) were cured and 6 @entity0 (5.9%) were improved. The @entity0 's satisfaction rate was 87.2% (89 of 102 @entity0 ). Overall, 41 @entity0 (40.2%) experienced 53 complications; 15 @entity0 (14.7%) presented de novo urgency, which was properly managed with anticholinergics, and 14 @entity0 (13.7%) underwent delayed sling readjustment for recurrent SUI (n  = 13) and urinary retention (n  = 1) during follow-up. Among 6 @entity0 (5.9%) with wound @entity1 , 4 @entity0 were successfully treated by daily dressing with antibiotics, and 2 @entity0 underwent removal of the Remeex system owing to intractable @entity1 . Most complications were classified as grade 1 (54.8%) or 2 (15.1%) and were successfully treated with minimal conservative measures. CONCLUSION: The Remeex system is a valuable adjunct for recurrent SUI after previous anti- @entity2 surgeries or @entity3 , considering most complications are Clavien grade I or II.

title: Midterm Efficacy and Complications of  Readjustable Midurethral Sling (Remeex System) in Female Stress XXXX With Recurrence or  @entity3 .

answer: @entity2


abstract: @entity4 sympathectomy is a very effective treatment of palmar @entity3 . The described endoscopic technique has given good primary results in 99% of @entity0 . After another session with this type of "minimal invasive surgery" 100% of the hands were satisfactorily dry. The hospital stay is just one post-operative day and the sick-leave is about a week. The drawbacks are minimal. @entity1 is tolerable and only eight @entity0 needed a post-operative B  lau-drainage because of pneumothorax or @entity2 . About 50% of @entity0 experience a compensatory increased sweating of the trunk, but this is related to a warm environment and regulation of body temperature and seems to decrease with time. This technique makes it possible to treat all those suffering from palmar @entity3 which can be a substantial, but underestimated handicap. To meet this kind of @entity0 after a successful operation is extremely satisfying even for the surgeon. The post-operative wet and cold hand has immediately post-operatively become warm and dry.

title: Thoracoscopic sympathicotomy for XXXX --surgical technique, complications and side effects.

answer: @entity3


abstract: UNASSIGNED: @entity5 is one of the most common @entity1 , affecting about 1-4% of @entity0 older than 60 years. Among the proposed mechanisms of @entity7 generation, free @entity1 is believed to play a pivotal role in the development and/or progression of the disease. Recently, PPARs, a class of transcription factors involved in several pathways both in physiological and pathological conditions, have been linked by us and others to @entity4 . Particularly, PPARy and its ligands have been indicated as potential therapeutic targets for the treatment of several pathological conditions associated with neuroinflammation within the CNS. The anti-inflammatory function of PPARy has attracted attention since agonists exert a broad spectrum of protective effects in several animal models of @entity1 , including @entity3 . On the other hand a detrimental role for @entity10 /   has been proposed in Alzheimer, being closely related to the decrease of @entity8 and Trkfl. On these bases, in this work we used a @entity9 hemi-lesioned @entity2 model, inducing @entity6 , to study the effects of the lesion at three time points from the lesion (1, 2 and 3 weeks), in relevant areas of @entity7 motor symptoms, such as substantia nigra and globus pallidus and in the area of reward and mood control, the nucleus accumbens. In particular, it was studied: i) the expression of @entity8 and its downstream signals; ii) the modulation of PPARs levels. The results obtained indicate the possible use of a dual @entity10 /   antagonist/PPARy agonist to counteract primary and secondary signs of @entity4 . This article is protected by copyright. All rights reserved.

title: @entity10 /   and y in a @entity2 Model of @entity5 : Possible Involvement in XXXX Symptoms.

answer: @entity7


abstract: UNASSIGNED: @entity5 is one of the most common @entity1 , affecting about 1-4% of @entity0 older than 60 years. Among the proposed mechanisms of @entity7 generation, free @entity1 is believed to play a pivotal role in the development and/or progression of the disease. Recently, PPARs, a class of transcription factors involved in several pathways both in physiological and pathological conditions, have been linked by us and others to @entity4 . Particularly, PPARy and its ligands have been indicated as potential therapeutic targets for the treatment of several pathological conditions associated with neuroinflammation within the CNS. The anti-inflammatory function of PPARy has attracted attention since agonists exert a broad spectrum of protective effects in several animal models of @entity1 , including @entity3 . On the other hand a detrimental role for @entity10 /   has been proposed in Alzheimer, being closely related to the decrease of @entity8 and Trkfl. On these bases, in this work we used a @entity9 hemi-lesioned @entity2 model, inducing @entity6 , to study the effects of the lesion at three time points from the lesion (1, 2 and 3 weeks), in relevant areas of @entity7 motor symptoms, such as substantia nigra and globus pallidus and in the area of reward and mood control, the nucleus accumbens. In particular, it was studied: i) the expression of @entity8 and its downstream signals; ii) the modulation of PPARs levels. The results obtained indicate the possible use of a dual @entity10 /   antagonist/PPARy agonist to counteract primary and secondary signs of @entity4 . This article is protected by copyright. All rights reserved.

title: @entity10 /   and y in a @entity2 Model of XXXX : Possible Involvement in @entity7 Symptoms.

answer: @entity5


abstract: UNASSIGNED: @entity5 is one of the most common @entity1 , affecting about 1-4% of @entity0 older than 60 years. Among the proposed mechanisms of @entity7 generation, free @entity1 is believed to play a pivotal role in the development and/or progression of the disease. Recently, PPARs, a class of transcription factors involved in several pathways both in physiological and pathological conditions, have been linked by us and others to @entity4 . Particularly, PPARy and its ligands have been indicated as potential therapeutic targets for the treatment of several pathological conditions associated with neuroinflammation within the CNS. The anti-inflammatory function of PPARy has attracted attention since agonists exert a broad spectrum of protective effects in several animal models of @entity1 , including @entity3 . On the other hand a detrimental role for @entity10 /   has been proposed in Alzheimer, being closely related to the decrease of @entity8 and Trkfl. On these bases, in this work we used a @entity9 hemi-lesioned @entity2 model, inducing @entity6 , to study the effects of the lesion at three time points from the lesion (1, 2 and 3 weeks), in relevant areas of @entity7 motor symptoms, such as substantia nigra and globus pallidus and in the area of reward and mood control, the nucleus accumbens. In particular, it was studied: i) the expression of @entity8 and its downstream signals; ii) the modulation of PPARs levels. The results obtained indicate the possible use of a dual @entity10 /   antagonist/PPARy agonist to counteract primary and secondary signs of @entity4 . This article is protected by copyright. All rights reserved.

title: XXXX /   and y in a @entity2 Model of @entity5 : Possible Involvement in @entity7 Symptoms.

answer: @entity10


abstract: UNASSIGNED: @entity5 is one of the most common @entity1 , affecting about 1-4% of @entity0 older than 60 years. Among the proposed mechanisms of @entity7 generation, free @entity1 is believed to play a pivotal role in the development and/or progression of the disease. Recently, PPARs, a class of transcription factors involved in several pathways both in physiological and pathological conditions, have been linked by us and others to @entity4 . Particularly, PPARy and its ligands have been indicated as potential therapeutic targets for the treatment of several pathological conditions associated with neuroinflammation within the CNS. The anti-inflammatory function of PPARy has attracted attention since agonists exert a broad spectrum of protective effects in several animal models of @entity1 , including @entity3 . On the other hand a detrimental role for @entity10 /   has been proposed in Alzheimer, being closely related to the decrease of @entity8 and Trkfl. On these bases, in this work we used a @entity9 hemi-lesioned @entity2 model, inducing @entity6 , to study the effects of the lesion at three time points from the lesion (1, 2 and 3 weeks), in relevant areas of @entity7 motor symptoms, such as substantia nigra and globus pallidus and in the area of reward and mood control, the nucleus accumbens. In particular, it was studied: i) the expression of @entity8 and its downstream signals; ii) the modulation of PPARs levels. The results obtained indicate the possible use of a dual @entity10 /   antagonist/PPARy agonist to counteract primary and secondary signs of @entity4 . This article is protected by copyright. All rights reserved.

title: @entity10 /   and y in a XXXX Model of @entity5 : Possible Involvement in @entity7 Symptoms.

answer: @entity2


abstract: Current knowledge of molecules involved in immunology and @entity0 results from the significant contributions of x-ray crystallography, a discipline that just celebrated its 100th anniversary. The histories of allergens and x-ray crystallography are intimately intertwined. The first enzyme structure to be determined was lysozyme, also known as the @entity2 food allergen Gal d 4. Crystallography determines the exact 3-dimensional positions of atoms in molecules. Structures of molecular complexes in the disciplines of immunology and @entity1 have revealed the atoms involved in  molecular interactions and mechanisms of disease. These complexes include peptides presented by MHC class II molecules, cytokines bound to their receptors, allergen-antibody complexes, and innate immune receptors with their ligands. The information derived from crystallographic studies provides insights into the function of molecules. Allergen function is one of the determinants of environmental exposure, which is essential for IgE sensitization. Proteolytic activity of allergens or their capacity to bind LPSs can also contribute to allergenicity. The atomic positions define the molecular surface that is accessible to antibodies. In turn, this surface determines antibody specificity and cross-reactivity, which are important factors for the selection of allergen panels used for molecular diagnosis and the interpretation of  clinical symptoms. This review celebrates the contributions of x-ray crystallography to clinical immunology and @entity1 , focusing on new molecular perspectives that influence the diagnosis and treatment of @entity0 .

title: 100  Years later: Celebrating the contributions of x-ray crystallography to XXXX and clinical immunology.

answer: @entity1


abstract: UNASSIGNED: Salivary biomarkers have shown to be useful to assess physiological stress in football, but their relationship with physical performance is unknown. The aims of this study were to investigate the effect of a football match on salivary @entity1 , @entity0 and @entity2 ( @entity2 ) concentrations in elite footballers, and to examine the relationship of physical performance during the match to these biomarkers. Nine elite football players were assessed before, during and after a friendly international match. Physical performance during the match was measured by time-motion analysis, whilst salivary @entity1 , @entity0 and @entity2 were measured before and 10  min post-match. The results showed that players covered an average of 9463      458  m during the match. Salivary @entity1 did not change post-match. @entity0 and @entity2 concentrations decreased by 30.6% and 74.5%, respectively. The @entity0 / @entity1 ( @entity3 ) ratio decreased by 64.2% after the match. Changes in @entity0 concentrations correlated (r  =  0.85) with distance covered. Pre- and post-match @entity0 levels correlated with post-match @entity2 concentrations (r  =  0.8 and 0.89, respectively). These results suggest that a football match induces catabolic stress as indicated by the decreased T/C ratio. It seems that footballers with smaller decreases in @entity0 levels covered more distance and decreased their immune function less.

title: Salivary hormones and XXXX in relation to physical performance in football.

answer: @entity2


abstract: BACKGROUND: The Improving Outcomes in @entity1 guidelines recommended centralisation of cystectomy services to improve outcomes for @entity2 ( @entity2 ) @entity0 . OBJECTIVE: To investigate trends in all-cause and cause-specific survival to see if there was an improvement in survival after centralisation was implemented. To analyse trends in the number of acute hospital trusts undertaking cystectomy. DESIGN, SETTING, AND @entity0 : We used routine data to capture information on radical cystectomy (RC) in @entity2 @entity0 aged 20 yr and older between 1998 and 2010 (n=16  033). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We calculated 30-d and 90-d mortality, and 30-d, 90-d, 1-yr, and 5-yr survival. The average number of RCs per trust was derived. Trends were identified using regression analysis. RESULTS AND LIMITATIONS: The 30-d crude mortality decreased from 5.2% to 2.1% (p<0.001) and 90-d crude mortality decreased from 10.3% to 5.1% (p<0.001). There was an increase in 30-d relative survival from 96% to 98% (p<0.001), in 90-d relative survival from 91% to 96% (p<0.001), in 1-yr relative survival from 71% to 80% (p<0.001), and in 5-yr relative survival from 49% to 56% (2004-2006 data; p<0.001). The mean number of RCs performed by trusts in England increased from six to 24 (p<0.001). Smoking status and stage at diagnosis were not available. CONCLUSIONS: Survival after RC has increased alongside decreases in short-term mortality. There is little evidence of a cohort effect. The trends in survival are linear and we conclude that the continued survival improvements are a result of a combination of service improvements that include service reconfiguration, improved surgical training, neoadjuvant chemotherapy, enhanced recovery principles, and continued improvements in perioperative care. @entity0 SUMMARY: We analysed routinely collected hospital data. Outcomes for @entity0 who undergo cystectomy have improved for all age groups. This is likely to be due to a combination of changes in practice.

title: Trends in Operative Caseload and Mortality Rates after Radical Cystectomy for XXXX in England for 1998-2010.

answer: @entity2


abstract: A @entity1 ( @entity1 ) was used to locate the distribution of @entity2 in normal skin and in various types of scar tissue: mature scar tissue, @entity0 and keloids. The study was intended to establish whether or not a deviant @entity2 distribution could explain the different clinical features of these scar tissues. The distribution of @entity2 was found to differ between the various scar tissues. In normal skin an intense @entity2 -staining was observed in the papillary dermis. In mature scar tissue the distribution of @entity2 resembled that of normal uninjured tissue, but the layer of @entity2 was thinner. In @entity0 , @entity2 occurred mainly as a narrow strip in the papillary dermis. Keloid tissue showed the least @entity2 -staining of the papillary layer and resembled that of the bulging reticular dermis. In contrast, the thickened granular and spinous layer of the keloid epidermis exhibited an intense @entity2 -staining. We suggest that the altered distribution and amount of @entity2 in these different scar tissues may contribute to their different clinical characteristics. This histochemical technique for the demonstration of @entity2 in scar tissue could be of use in clinical work to decide on therapeutic strategies.

title: The distribution of hyaluronan in human skin and mature, XXXX .

answer: @entity0


abstract: @entity5 constitute a group of very rare diseases and occur with a frequency of 1/250,000 to 1/20,000 of hospitalizations. Even though they are benign lesions, their complications may turn into a life-threatening condition. They usually occur in @entity0 (90%), they are either congenital or they appear before the @entity0 's second birthday. Occassionally they are found in adults. @entity5 are usually localized around neck, but also near armpits and in the groin area. Less than 1% of lymphagiomas are detected in the retroperitoneal space and intestinal mesentery. @entity3 derived from lymphatic vessels can be divided into ordinary ones, usually known as capillary, cavernous, and cystic. The @entity1 ( @entity5 mesenteri) is the least common. It occurs mostly in the retroperitoneal space, mesentery of the colon, or extremely rarely in the mesentery of the small intestine. Preoperative diagnosis is difficult due to non-specific clinical symptoms and noncharacteristic image in the diagnostic tests. @entity5 complications, such as @entity4 or perforation, and persistent @entity2 , are the cause of exploratory laparotomy. Final diagnosis requires microscopic examination of material collected during an operation. This article presented the case of a 40-year-old female, operated due to the obstruction of the gastrointestinal tract, in whose case the @entity5 was recognised in postoperative histopathological examination of the @entity1 from the jejunal mesentery. Since @entity0 with these @entity1 have good chances of complete recovery - if there are no serious complications - it appears that the optimal therapeutic procedure should be early surgery, which reduces the possibility of complications.

title: Multiannual abdominal XXXX complicated by obstruction of the gastrointestinal tract in the course of cystic form of mesenteric lymhangioma of the small intestine.

answer: @entity2


abstract: UNASSIGNED: Metal oxide transport layers have played a crucial role in recent progress in organic photovoltaic (OPV) device stability. Here, we measure the stability of inverted and encapsulated @entity2 : @entity1 cells with @entity3 /Ag/Al composite anode in operational conditions combining solar radiation and 65   C. Performance loss of over 50% in the first 100 h of the aging is dominated by a drop in the short-circuit current (Jsc). We reveal a concurrent loss in reflectance from 85% to 50% above 650 nm, which is below the optical gap of the used photoactive materials, hence, excluding any major degradation in the bulk of this layer. Correlating the responses of aged devices to a series of test structures comprised of ITO/ @entity0 cathode, @entity3 /Ag, and @entity3 /Ag/Al anodes and their combinations with the active layer allowed us to identify that the presence of Al causes the reduced reflectance in these devices, independent of the presence of the active layer. Systematic single-stress aging on the test structures further indicates that elevated heat is the cause of the reflectance loss. Cross-section transmission electron microscopy coupled with elemental analysis revealed the unsuspected role of Al; notably, it diffuses through the entire 150 nm thick Ag layer and accumulates at the @entity3 /Ag interface. Moreover, XRD analysis of the aged @entity3 /Ag/Al anode indicates the formation of Ag2Al alloy. Depth profiling with X-ray photoelectron spectroscopy advanced our understanding by confirming the formation of Ag-Al intermetallic alloy and the presence of oxidized Al only at the @entity3 /Ag interface suggesting a concomitant reduction of @entity3 to most probably @entity4 . This latter compound is less reflective than @entity3 , which can explain the reduced reflectance in aged devices as proven by optical simulations. On the basis of these results, we could estimate that 20% of the loss in Jsc is ascribed to reduction of @entity3 triggered by its direct contact with Al.

title: Root-Cause Failure Analysis of Photocurrent Loss in XXXX : @entity1 -Based Inverted Solar Cells.

answer: @entity2


abstract: UNASSIGNED: Metal oxide transport layers have played a crucial role in recent progress in organic photovoltaic (OPV) device stability. Here, we measure the stability of inverted and encapsulated @entity2 : @entity1 cells with @entity3 /Ag/Al composite anode in operational conditions combining solar radiation and 65   C. Performance loss of over 50% in the first 100 h of the aging is dominated by a drop in the short-circuit current (Jsc). We reveal a concurrent loss in reflectance from 85% to 50% above 650 nm, which is below the optical gap of the used photoactive materials, hence, excluding any major degradation in the bulk of this layer. Correlating the responses of aged devices to a series of test structures comprised of ITO/ @entity0 cathode, @entity3 /Ag, and @entity3 /Ag/Al anodes and their combinations with the active layer allowed us to identify that the presence of Al causes the reduced reflectance in these devices, independent of the presence of the active layer. Systematic single-stress aging on the test structures further indicates that elevated heat is the cause of the reflectance loss. Cross-section transmission electron microscopy coupled with elemental analysis revealed the unsuspected role of Al; notably, it diffuses through the entire 150 nm thick Ag layer and accumulates at the @entity3 /Ag interface. Moreover, XRD analysis of the aged @entity3 /Ag/Al anode indicates the formation of Ag2Al alloy. Depth profiling with X-ray photoelectron spectroscopy advanced our understanding by confirming the formation of Ag-Al intermetallic alloy and the presence of oxidized Al only at the @entity3 /Ag interface suggesting a concomitant reduction of @entity3 to most probably @entity4 . This latter compound is less reflective than @entity3 , which can explain the reduced reflectance in aged devices as proven by optical simulations. On the basis of these results, we could estimate that 20% of the loss in Jsc is ascribed to reduction of @entity3 triggered by its direct contact with Al.

title: Root-Cause Failure Analysis of Photocurrent Loss in @entity2 : XXXX -Based Inverted Solar Cells.

answer: @entity1


abstract: OBJECTIVE: This study investigated the @entity1 ( @entity1 ) outcome of @entity6 -releasing intrauterine system (LNG-IUS) pretreatment for @entity5 (EH) in @entity0 with @entity7 ( @entity7 ) undergoing @entity1 embryo transfer ( @entity1 -ET). METHODS: One hundred ninety @entity0 with @entity7 and simple EH without cytologic atypia were allocated randomly to 2 independent arms, that is, the LNG-IUS group (90 @entity0 ) and the non-LNG-IUS group (100 @entity0 ). Four hundred fourteen @entity0 with @entity7 without @entity4 comprised the control group. Each @entity0 was reevaluated by transvaginal ultrasonography (TVS) and endometrial biopsy after 6 months. For each @entity0 , @entity1 outcome measures, such as number of recombinant follicle-stimulating hormone, endometrial thickness on @entity0 chorionic gonadotropin (HCG) day, hormone levels ( @entity3 , luetinizing hormone, and serum @entity2 ) on HCG day, number of oocytes, fertilization rate, clinical pregnancy rate, and miscarriage rate were compared among the 3 groups. RESULTS: In general, the 3 groups did not differ with respect to the main clinical and biochemical data. After 6 months, @entity0 in LNG-IUS group had an EH resolution rate of 87.77%. In the non-LNG-IUS group, the resolution rate was 15.00%, and 3% of these @entity0 showed progression of EH. The clinical pregnancy rates in the non-LNG-IUS group were significantly lower (28.04%) than that in the LNG-IUS group (46.06%) and the control group (44.65%). The miscarriage rate was highest in the non-LNG-IUS group, but no significant difference in miscarriage rate existed among the 3 groups. CONCLUSION: The study illustrates that the LNG-IUS can be safely used for 6 months as a treatment for @entity0 with @entity7 and simple EH. Additionally, use of the LNG-IUS can increase the clinical pregnancy rates and implantation rates of @entity0 with @entity7 and simple EH who undergo @entity8 agonist @entity1 -ET protocols.

title: Efficacy of the Levonorgestrel-Releasing Intrauterine System on @entity1 -ET Outcomes in XXXX With @entity5 .

answer: @entity7


abstract: OBJECTIVE: This study investigated the @entity1 ( @entity1 ) outcome of @entity6 -releasing intrauterine system (LNG-IUS) pretreatment for @entity5 (EH) in @entity0 with @entity7 ( @entity7 ) undergoing @entity1 embryo transfer ( @entity1 -ET). METHODS: One hundred ninety @entity0 with @entity7 and simple EH without cytologic atypia were allocated randomly to 2 independent arms, that is, the LNG-IUS group (90 @entity0 ) and the non-LNG-IUS group (100 @entity0 ). Four hundred fourteen @entity0 with @entity7 without @entity4 comprised the control group. Each @entity0 was reevaluated by transvaginal ultrasonography (TVS) and endometrial biopsy after 6 months. For each @entity0 , @entity1 outcome measures, such as number of recombinant follicle-stimulating hormone, endometrial thickness on @entity0 chorionic gonadotropin (HCG) day, hormone levels ( @entity3 , luetinizing hormone, and serum @entity2 ) on HCG day, number of oocytes, fertilization rate, clinical pregnancy rate, and miscarriage rate were compared among the 3 groups. RESULTS: In general, the 3 groups did not differ with respect to the main clinical and biochemical data. After 6 months, @entity0 in LNG-IUS group had an EH resolution rate of 87.77%. In the non-LNG-IUS group, the resolution rate was 15.00%, and 3% of these @entity0 showed progression of EH. The clinical pregnancy rates in the non-LNG-IUS group were significantly lower (28.04%) than that in the LNG-IUS group (46.06%) and the control group (44.65%). The miscarriage rate was highest in the non-LNG-IUS group, but no significant difference in miscarriage rate existed among the 3 groups. CONCLUSION: The study illustrates that the LNG-IUS can be safely used for 6 months as a treatment for @entity0 with @entity7 and simple EH. Additionally, use of the LNG-IUS can increase the clinical pregnancy rates and implantation rates of @entity0 with @entity7 and simple EH who undergo @entity8 agonist @entity1 -ET protocols.

title: Efficacy of the Levonorgestrel-Releasing Intrauterine System on @entity1 -ET Outcomes in @entity7 With XXXX .

answer: @entity5


abstract: OBJECTIVE: This study investigated the @entity1 ( @entity1 ) outcome of @entity6 -releasing intrauterine system (LNG-IUS) pretreatment for @entity5 (EH) in @entity0 with @entity7 ( @entity7 ) undergoing @entity1 embryo transfer ( @entity1 -ET). METHODS: One hundred ninety @entity0 with @entity7 and simple EH without cytologic atypia were allocated randomly to 2 independent arms, that is, the LNG-IUS group (90 @entity0 ) and the non-LNG-IUS group (100 @entity0 ). Four hundred fourteen @entity0 with @entity7 without @entity4 comprised the control group. Each @entity0 was reevaluated by transvaginal ultrasonography (TVS) and endometrial biopsy after 6 months. For each @entity0 , @entity1 outcome measures, such as number of recombinant follicle-stimulating hormone, endometrial thickness on @entity0 chorionic gonadotropin (HCG) day, hormone levels ( @entity3 , luetinizing hormone, and serum @entity2 ) on HCG day, number of oocytes, fertilization rate, clinical pregnancy rate, and miscarriage rate were compared among the 3 groups. RESULTS: In general, the 3 groups did not differ with respect to the main clinical and biochemical data. After 6 months, @entity0 in LNG-IUS group had an EH resolution rate of 87.77%. In the non-LNG-IUS group, the resolution rate was 15.00%, and 3% of these @entity0 showed progression of EH. The clinical pregnancy rates in the non-LNG-IUS group were significantly lower (28.04%) than that in the LNG-IUS group (46.06%) and the control group (44.65%). The miscarriage rate was highest in the non-LNG-IUS group, but no significant difference in miscarriage rate existed among the 3 groups. CONCLUSION: The study illustrates that the LNG-IUS can be safely used for 6 months as a treatment for @entity0 with @entity7 and simple EH. Additionally, use of the LNG-IUS can increase the clinical pregnancy rates and implantation rates of @entity0 with @entity7 and simple EH who undergo @entity8 agonist @entity1 -ET protocols.

title: Efficacy of the Levonorgestrel-Releasing Intrauterine System on XXXX -ET Outcomes in @entity7 With @entity5 .

answer: @entity1


abstract: @entity7 ( @entity7 ) is a potentially life-threatening disease, which usually presents with @entity2 or @entity3 . @entity7 presenting with isolated @entity1 is rare, and no case with isolated @entity5 - ( @entity8 -) like @entity1 has been reported. Here, we report the case of a 57-year-old male with @entity7 who presented with acute @entity1 that extended from his left cheek to his left forehead and auricle. He felt a brief stabbing @entity1 when his face was touched in the territory of the first and second divisions of the left trigeminal nerve. There were no other neurological signs. Magnetic resonance imaging (MRI) of the brain 7 days after onset revealed dissection of the @entity7 without @entity6 . The @entity1 gradually disappeared in approximately 6 weeks, and the @entity0 remained asymptomatic thereafter, except for a brief episode of vertigo. Follow-up MRI revealed progressive @entity4 without @entity6 . This case indicates that @entity7 can present with isolated @entity1 that mimics @entity8 . @entity7 should be considered in the differential diagnosis of acute @entity1 or @entity8 .

title: Progressive Intracranial Vertebral Artery Dissection Presenting with Isolated Trigeminal Neuralgia-Like XXXX .

answer: @entity1


abstract: OBJECTIVES: To evaluate the efficacy and safety of very low dose @entity7 in improving pelvic @entity2 in @entity0 with @entity1 , the benefit of preceding the treatment by a short course of a GnRH agonist, symptoms recurrence after drug withdrawal, and variations in menstrual pattern. DESIGN: Open-label, randomized study. SETTING: University hospital @entity1 center. @entity0 : Forty-two @entity0 with moderate or severe pelvic @entity2 and laparoscopically diagnosed @entity1 . INTERVENTIONS: Treatment with oral @entity7 , 50 mg/d, for 9 months (group I, n = 21) or @entity8 depot for 3 months followed by oral @entity7 , 50 mg/d, for 6 months (group II, n = 21), and a 6-month follow-up. MAIN OUTCOME MEASURES: Variations in severity of symptoms during treatment and at the end of follow-up as shown by a linear analog scale and a verbal rating scale; menstrual @entity4 as assessed by a pictorial chart. RESULTS: Four @entity0 withdrew from the study, one in each group at the fifth month of treatment (for persistent @entity2 ) and one in each group during follow-up (they requested additional therapy); one @entity0 in group I was lost to follow-up. Significant improvements were obtained in @entity6 , @entity5 , and @entity2 in both treatment schedules without differences between the groups. Also menstrual @entity4 was significantly reduced in both groups. A temporary fall in high and rise in low density lipoprotein @entity3 was observed in the study population. At the end of follow-up symptoms recurred without significant differences in median @entity2 scores with respect to baseline. CONCLUSION: Very low dose @entity7 may be an alternative for temporary relief of @entity2 . Ovulation is not always inhibited and barrier contraception is needed. Side effects occur but are rarely severe. Further data are required to evaluate the influence of long-term administration on the lipid profile.

title: Very low dose XXXX for relief of endometriosis-associated pelvic pain: a pilot study.

answer: @entity7


abstract: OBJECTIVES: To prospectively examine how age and comorbidity affect screening mammography use, @entity3 detection, and overall survival. DESIGN: Prospective, with median follow-up of 10.2  years. SETTING: A population-based cohort of Vermont @entity1 with data in the Vermont @entity0 Surveillance System. @entity1 : @entity1 aged 70 and older with no history of @entity0 (N  =  20,697). MEASUREMENTS: Rates of screening, diagnostic procedure use, and @entity0 diagnosis were examined according to age and comorbidity. The effect of @entity0 on overall survival was assessed in relation to detection mode, @entity3 characteristics, and treatment. RESULTS: Screening declined 9% per year after age 70 and 18% with each unit increase in comorbidity score, with corresponding increases in clinically detected @entity0 . @entity2 was associated with greater overall mortality (screen detected: hazard ratio (HR)  =  1.22, 95% confidence interval (CI)   =  1.07-1.40; clinically detected: HR  =  1.68, 95% CI  =  1.43-1.96). The latter HR reflects a much greater absolute risk of @entity4 for @entity1 in a population with high baseline mortality. Use of breast-conserving surgery as the only treatment for Stage I @entity3 increased markedly with age and was associated with shorter overall survival than radiation or mastectomy (relative risk  =  2.23, 95% CI  =  1.42-3.47). CONCLUSION: Lower screening mammography use by older @entity1 is associated with more clinically detected @entity0 , which are associated with poorer survival. Treatment received for early-stage @entity3 influences the effect of screening on survival.

title: A Prospective Study of the Use and Effects of Screening Mammography in XXXX Aged 70 and Older.

answer: @entity1


abstract: Background Deficits in face emotion perception are among the most pervasive aspects of @entity1 which strongly affects interpersonal communication and social skills. Material and Methods @entity3 @entity0 (PSZ) and healthy control subjects (HCS) performed 2 psychophysical tasks. One, the SAFFIMAP test, was designed to determine the impact of subliminally presented affective or neutral images on the accuracy of face-expression (angry or neutral) perception. In the second test, FEP, subjects saw pictures of face-expression and were asked to rate them as angry, happy, or neutral. The following clinical scales were used to determine the acute symptoms in PSZ: Positive and Negative Syndrome (PANSS), Young Mania Rating (YMRS), Hamilton @entity4 (HAM-D), and Hamilton @entity2 (HAM-A). Results On the SAFFIMAP test, different from the HCS group, the PSZ group tended to categorize the neutral expression of test faces as angry and their response to the test-face expression was not influenced by the affective content of the primes. In PSZ, the PANSS-positive score was significantly correlated with correct perception of angry faces for aggressive or pleasant primes. YMRS scores were strongly correlated with PSZ's tendency to recognize angry face expressions when the prime was a pleasant or a neutral image. The HAM-D score was positively correlated with categorizing the test-faces as neutral, regardless of the affective content of the prime or of the test-face expression (angry or neutral). Conclusions Despite its exploratory nature, this study provides the first evidence that conscious perception and categorization of facial emotions (neutral or angry) in PSZ is directly affected by their positive or negative symptoms of the disease as defined by their individual scores on the clinical diagnostic scales.

title: When does Subliminal Affective Image Priming Influence the Ability of XXXX @entity0 to Perceive Face Emotions?

answer: @entity3


abstract: Background Deficits in face emotion perception are among the most pervasive aspects of @entity1 which strongly affects interpersonal communication and social skills. Material and Methods @entity3 @entity0 (PSZ) and healthy control subjects (HCS) performed 2 psychophysical tasks. One, the SAFFIMAP test, was designed to determine the impact of subliminally presented affective or neutral images on the accuracy of face-expression (angry or neutral) perception. In the second test, FEP, subjects saw pictures of face-expression and were asked to rate them as angry, happy, or neutral. The following clinical scales were used to determine the acute symptoms in PSZ: Positive and Negative Syndrome (PANSS), Young Mania Rating (YMRS), Hamilton @entity4 (HAM-D), and Hamilton @entity2 (HAM-A). Results On the SAFFIMAP test, different from the HCS group, the PSZ group tended to categorize the neutral expression of test faces as angry and their response to the test-face expression was not influenced by the affective content of the primes. In PSZ, the PANSS-positive score was significantly correlated with correct perception of angry faces for aggressive or pleasant primes. YMRS scores were strongly correlated with PSZ's tendency to recognize angry face expressions when the prime was a pleasant or a neutral image. The HAM-D score was positively correlated with categorizing the test-faces as neutral, regardless of the affective content of the prime or of the test-face expression (angry or neutral). Conclusions Despite its exploratory nature, this study provides the first evidence that conscious perception and categorization of facial emotions (neutral or angry) in PSZ is directly affected by their positive or negative symptoms of the disease as defined by their individual scores on the clinical diagnostic scales.

title: When does Subliminal Affective Image Priming Influence the Ability of @entity3 XXXX to Perceive Face Emotions?

answer: @entity0


abstract: We investigated 37 long term survivors of childhood @entity1 to study the relationship among growth, GH secretion, and pituitary size. The median follow-up time after diagnosis was 13.2 yr. The pituitary gland was visualized with magnetic resonance imaging. Radiated @entity0 (n = 25) had a reduced relative height and showed a greater reduction in relative height after diagnosis than nonradiated @entity0 (n = 12). The @entity0 had lower spontaneous nocturnal GH secretion than controls due to a reduced peak amplitude. Spontaneous GH secretion was lower in radiated @entity0 than in nonradiated subjects. The @entity0 had lower plasma @entity3 ( @entity3 ) and serum @entity5 ( @entity5 ) concentrations than the controls. Radiated subjects had decreased @entity3 and @entity5 concentrations compared to nonradiated subjects. Half of the @entity0 (20 of 37) evaluated with magnetic resonance imaging had a reduced pituitary size (pituitary height, < -2 SD score). Radiated subjects had smaller pituitary glands than nonradiated ones. Seventeen of 20 @entity0 (85%) with reduced pituitary size had decreased nocturnal GH release. There was a positive correlation between nocturnal GH secretion, plasma @entity3 , and serum @entity5 levels, on the one hand, and pituitary height, on the other. These results indicate that cranial radiation may result in tissue damage, leading to decreased pituitary size, reduced spontaneous GH secretion, and @entity4 . The finding of reduced @entity3 levels in both radiated and nonradiated @entity0 combined with decreased @entity5 concentrations in radiated @entity0 , indicates that cytotoxic chemotherapy may induce @entity2 resulting in decreased @entity3 synthesis.

title: Pituitary size assessed with magnetic resonance imaging as a measure of growth hormone secretion in long term survivors of childhood XXXX .

answer: @entity1


abstract: A clinicopathological study of 56 pediatric @entity0 with non-ACTH-secreting @entity5 removed by a transsphenoidal neurosurgical approach was undertaken to better define the clinical presentation, to assess demographic factors, to determine the immunohistochemical staining characteristics of the @entity1 , and to evaluate the outcome of transsphenoidal surgical treatment and other adjuvant therapies. A separate analysis of @entity7 @entity0 was performed. All @entity1 were confirmed histologically and immunophenotyped for pituitary hormones. Forty-one @entity0 had @entity1 that stained for PRL alone, eight @entity0 had @entity1 that stained for PRL and GH, six @entity0 had @entity4 , and one @entity0 had a @entity1 that stained for glycoprotein hormones. No @entity1 contained GH alone. Macroadenomas exceeded microadenomas (1.4:1). There were no male @entity0 with microadenomas of any type. Females outnumbered males (3.3:1). @entity0 presented most frequently with @entity2 , @entity6 (in females), @entity10 , and @entity9 . All but one of the @entity0 with @entity9 at presentation had macroadenomas. @entity1 staining characteristics did not always correlate well with clinical status, especially with regard to GH-containing @entity1 . Pediatric @entity5 did not appear to be more invasive or more @entity3 than adult @entity5 , contrary to some previous reports. The @entity0 with microadenomas had a 70% operative cure rate and a 65% long term cure rate; the recurrence rate for microadenoma @entity0 was 25%. Macroadenoma @entity0 had a 33% operative cure rate, a 55% long term cure rate, and a recurrence rate of 33%. Thus, microadenoma and macroadenoma @entity0 had similar long term cure rates, but macroadenoma @entity0 required more @entity3 adjuvant therapy (second surgery, radiation, or @entity8 ) and had higher rates of @entity9 (52% of macroadenoma @entity0 vs. 0% of microadenoma @entity0 required long term hormone replacement).

title: XXXX in childhood and adolescence.

answer: @entity5


abstract: Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are believed to be important in fetal growth and development. In the current study, the developmental changes in the IGF and @entity3 were examined in 23 paired samples of @entity0 @entity6 ( @entity6 ), extraembryonic coelomic (EEC) fluid, and @entity7 ( @entity7 ) between 9 and 12 weeks gestation. Levels of @entity1 were very low in @entity6 (7 +/- 3 ng/mL) and EEC (10 +/- 3 ng/mL) compared to those in @entity7 (237 +/- 42 ng/mL). In contrast, @entity5 concentrations were 210 +/- 36 and 174 +/- 22 ng/mL in @entity6 and EEC, respectively, and were approximately 25% of @entity7 serum levels (884 +/- 122 ng/mL). There was no @entity2 on gestational age for either peptide in @entity6 or EEC during the period of gestation examined. @entity8 levels in @entity6 increased about 20-fold (1.6 +/- 0.3 to 33.0 +/- 0.1 ng/mL) between 9 and 12 weeks of pregnancy, and @entity8 levels were nearly 2 orders of magnitude higher in EEC, increasing about 100-fold (365 +/- 119 to 3014 +/- 100.0 ng/mL) by the end of the first trimester. In contrast, @entity8 levels were low in @entity7 (24.9 +/- 3.5 ng/mL) and showed no gestational age @entity2 . Using RIA, high levels of @entity4 were found in EEC (2062 +/- 177 ng/mL) and @entity7 (6590 +/- 357 ng/mL) compared to those in @entity6 (152 +/- 24 ng/mL). Levels of @entity4 in @entity7 and EEC did not change significantly with gestational age, whereas an increase in @entity8 was observed in @entity6 after the tenth week of pregnancy. In contrast to high levels of @entity4 in @entity7 and EEC, determined by RIA, the 37- to 43-kilodalton @entity4 doublet was barely detectable by Western ligand blot analysis. This discrepancy suggested the presence of an @entity4 protease in EEC, as has been found in @entity7 , that decreases the affinity of this BP for IGF peptides and, therefore, renders it less readily detectable by Western ligand blot analysis. Using [125I] @entity4 as substrate, lower levels of @entity4 protease activity were detected in EEC compared to @entity7 , and nearly undetectable levels were found in @entity6 . By Western immunoblotting, a smaller (28-kilodalton) immunoreactive form of @entity4 was detected only in @entity7 and EEC, suggesting proteolyzed @entity4 in @entity7 and EEC, but not in @entity6 , during this gestational period.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed XXXX in embryonic cavities in early @entity0 pregnancy: their potential relevance to maternal-embryonic and fetal interactions.

answer: @entity4


abstract: Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are believed to be important in fetal growth and development. In the current study, the developmental changes in the IGF and @entity3 were examined in 23 paired samples of @entity0 @entity6 ( @entity6 ), extraembryonic coelomic (EEC) fluid, and @entity7 ( @entity7 ) between 9 and 12 weeks gestation. Levels of @entity1 were very low in @entity6 (7 +/- 3 ng/mL) and EEC (10 +/- 3 ng/mL) compared to those in @entity7 (237 +/- 42 ng/mL). In contrast, @entity5 concentrations were 210 +/- 36 and 174 +/- 22 ng/mL in @entity6 and EEC, respectively, and were approximately 25% of @entity7 serum levels (884 +/- 122 ng/mL). There was no @entity2 on gestational age for either peptide in @entity6 or EEC during the period of gestation examined. @entity8 levels in @entity6 increased about 20-fold (1.6 +/- 0.3 to 33.0 +/- 0.1 ng/mL) between 9 and 12 weeks of pregnancy, and @entity8 levels were nearly 2 orders of magnitude higher in EEC, increasing about 100-fold (365 +/- 119 to 3014 +/- 100.0 ng/mL) by the end of the first trimester. In contrast, @entity8 levels were low in @entity7 (24.9 +/- 3.5 ng/mL) and showed no gestational age @entity2 . Using RIA, high levels of @entity4 were found in EEC (2062 +/- 177 ng/mL) and @entity7 (6590 +/- 357 ng/mL) compared to those in @entity6 (152 +/- 24 ng/mL). Levels of @entity4 in @entity7 and EEC did not change significantly with gestational age, whereas an increase in @entity8 was observed in @entity6 after the tenth week of pregnancy. In contrast to high levels of @entity4 in @entity7 and EEC, determined by RIA, the 37- to 43-kilodalton @entity4 doublet was barely detectable by Western ligand blot analysis. This discrepancy suggested the presence of an @entity4 protease in EEC, as has been found in @entity7 , that decreases the affinity of this BP for IGF peptides and, therefore, renders it less readily detectable by Western ligand blot analysis. Using [125I] @entity4 as substrate, lower levels of @entity4 protease activity were detected in EEC compared to @entity7 , and nearly undetectable levels were found in @entity6 . By Western immunoblotting, a smaller (28-kilodalton) immunoreactive form of @entity4 was detected only in @entity7 and EEC, suggesting proteolyzed @entity4 in @entity7 and EEC, but not in @entity6 , during this gestational period.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and proteolyzed @entity4 in embryonic cavities in early XXXX pregnancy: their potential relevance to maternal-embryonic and fetal interactions.

answer: @entity0