abstract: Forty-five @entity0 with @entity4 were treated with @entity5 ( @entity5 ) and @entity6 . @entity0 received @entity5 , 100 mg orally daily; @entity6 administration, 300 mg orally four times daily, was initiated on day 15 of therapy, and treatment with both drugs was continued until progression of disease. Three @entity0 are too early to evaluate (on study less than or equal to 2 months with no change in @entity1 status). Objective responses (greater than or equal to 50% reduction in measurable disease) occurred in 14 of 42 evaluable @entity0 (33.3%) (the 95% confidence interval based on this rate is +/- 14.3%), with three complete responses and 11 partial responses (PR). Complete responses lasted 9.5, 4+, and 9.5+ months. The median duration of response for the PR group was 5 months (range, 4 to 21+ months). Twelve @entity0 experienced stabilization of disease ranging from 4 to 16.5+ months. No response was seen in 16 @entity0 . There was no symptomatic, hematologic, or chemical (organ dysfunction) @entity2 among the 45 @entity0 treated. @entity5 and @entity6 appear to be safe and active agents in the treatment of metastatic @entity3 . Further studies are required to determine the optimal dose and scheduling of these agents.

title: Treatment of @entity4 with @entity5 ( XXXX ) and @entity6 : a pilot study.

answer: @entity5


abstract: Forty-five @entity0 with @entity4 were treated with @entity5 ( @entity5 ) and @entity6 . @entity0 received @entity5 , 100 mg orally daily; @entity6 administration, 300 mg orally four times daily, was initiated on day 15 of therapy, and treatment with both drugs was continued until progression of disease. Three @entity0 are too early to evaluate (on study less than or equal to 2 months with no change in @entity1 status). Objective responses (greater than or equal to 50% reduction in measurable disease) occurred in 14 of 42 evaluable @entity0 (33.3%) (the 95% confidence interval based on this rate is +/- 14.3%), with three complete responses and 11 partial responses (PR). Complete responses lasted 9.5, 4+, and 9.5+ months. The median duration of response for the PR group was 5 months (range, 4 to 21+ months). Twelve @entity0 experienced stabilization of disease ranging from 4 to 16.5+ months. No response was seen in 16 @entity0 . There was no symptomatic, hematologic, or chemical (organ dysfunction) @entity2 among the 45 @entity0 treated. @entity5 and @entity6 appear to be safe and active agents in the treatment of metastatic @entity3 . Further studies are required to determine the optimal dose and scheduling of these agents.

title: Treatment of @entity4 with @entity5 ( @entity5 ) and XXXX : a pilot study.

answer: @entity6


abstract: One hundred sixty-three @entity0 undergoing reoperative parathyroidectomy were evaluated before and after operation to determine the incidence of, risk factors for, and morbidity of @entity1 . These @entity0 were compared to 77 @entity0 undergoing initial parathyroid operation, only one of whom had @entity1 on postoperative indirect laryngoscopy (1.3%). Preoperative examination of the reoperative @entity0 revealed @entity1 from initial exploration in 11 @entity0 who were excluded from this study. After re-exploration, 10 @entity0 (6.6%) had @entity1 , eight unilateral and two bilateral. Right vocal cords were paralyzed twice as often as left. In 90%, @entity1 was associated with removal or biopsy of an ipsilateral gland. @entity1 occurred despite intraoperative visualization of the recurrent laryngeal nerves. Preoperative localization, parathyroid gland pathology, and concomitant thyroidectomy were not associated with increased risk of @entity1 . Hoarseness was the major symptom. Tracheostomy was required for two @entity0 , one was permanent. One @entity0 was treated for aspiration with a temporary gastrostomy. Nine of 10 @entity0 had return of normal voice quality in an average of 4 months time. On examination 4 years or more after surgery, two of five @entity0 had normal vocal cord motion. The oblique anatomic course of the right recurrent laryngeal nerve may account for the greater frequency of right @entity1 .

title: XXXX and reoperative parathyroidectomy. A prospective study.

answer: @entity1


abstract: OBJECTIVE: To evaluate the short-term effect of physical exercise and a cognitive intervention in @entity2 . DESIGN: Randomized controlled trial. SUBJECTS: Ninety-three @entity0 sick-listed for 8-12 weeks for @entity2 were randomized to an exercise regime (n = 30), a cognitive intervention (n = 34) or a control group (n = 29). METHODS: Primary outcome measures were @entity1 , disability, sick-listing and satisfaction with care. Secondary outcome measures were self-efficacy for @entity1 and for function, fear-avoidance beliefs, emotional distress, generic health status and life satisfaction. RESULTS: Eighteen percent of subjects dropped out. Drop-out was most frequent in the exercise group. At 18 weeks after inclusion fear-avoidance beliefs were reduced in both intervention groups. The cognitive group demonstrated significant improvement in disability, self-efficacy for @entity1 , general health and life satisfaction. @entity0 in the exercise group were significantly more satisfied with the treatment, and @entity0 following the exercise protocol reduced @entity1 significantly. No effect on sick-listing was seen. CONCLUSION: Cognitive intervention improved disability and may be feasible for most @entity0 sick-listed in the sub-acute phase. Physical exercise reduced @entity0 ' symptoms, but requires high motivation by @entity0 . Despite positive effects in intervention groups on variables considered as negative prognostic factors for long-term disability and sickness absence, interventions had no effect on sick-listing.

title: Intensive group training versus cognitive intervention in XXXX : short-term results of a single-blind randomized controlled trial.

answer: @entity2


abstract: Seven @entity0 with @entity4 right ventricle and subpulmonary @entity6 (the @entity4 ) underwent anatomical repair at the arterial level with transfer of the coronary arteries. At the time of operation, @entity0 ages ranged from 6 weeks to 33 months (mean 14.1 months) and weight ranged from 3.7 to 11.5 kg (mean 7.0 kg). Four @entity0 had prior pulmonary artery banding: Two of these four also had @entity5 repairs, and one had a Blalock-Hanlon septectomy. Three different patterns of coronary artery distribution were encountered. Five @entity0 had side-to-side great arteries, and two had more or less anteroposterior great arterial relationships. There was one operative @entity2 (14.3%: 70% confidence limits 1.9 - 40.7%) resulting from muscular subvalvular right ventricular outflow tract obstruction (RVOTO). There have been no late deaths in the six survivors followed 6 to 31 months postoperatively (mean 14.8 months). One @entity0 required closure of a residual @entity6 ( @entity6 ) and infundibular resection for RVOTO 4 months postoperatively. All other survivors are functionally NYHA Class I. Five of the six survivors have undergone postoperative catheterization (mean interval 5.8 months). There was no @entity3 and good ventricular function in all @entity0 . In addition to the @entity0 with the residual @entity6 , two other asymptomatic @entity0 had mild or moderate RVOTO. Compared with alternative surgical procedures for this @entity1 , anatomic correction has the advantages of acceptable operative mortality, use of the left ventricle as the systemic ventricle, no need for extracardiac conduits, and applicability to @entity0 with all variations of coronary artery and great artery anatomy.

title: Anatomic correction of XXXX right ventricle with subpulmonary @entity6 (the " @entity4 ).

answer: @entity4


abstract: Seven @entity0 with @entity4 right ventricle and subpulmonary @entity6 (the @entity4 ) underwent anatomical repair at the arterial level with transfer of the coronary arteries. At the time of operation, @entity0 ages ranged from 6 weeks to 33 months (mean 14.1 months) and weight ranged from 3.7 to 11.5 kg (mean 7.0 kg). Four @entity0 had prior pulmonary artery banding: Two of these four also had @entity5 repairs, and one had a Blalock-Hanlon septectomy. Three different patterns of coronary artery distribution were encountered. Five @entity0 had side-to-side great arteries, and two had more or less anteroposterior great arterial relationships. There was one operative @entity2 (14.3%: 70% confidence limits 1.9 - 40.7%) resulting from muscular subvalvular right ventricular outflow tract obstruction (RVOTO). There have been no late deaths in the six survivors followed 6 to 31 months postoperatively (mean 14.8 months). One @entity0 required closure of a residual @entity6 ( @entity6 ) and infundibular resection for RVOTO 4 months postoperatively. All other survivors are functionally NYHA Class I. Five of the six survivors have undergone postoperative catheterization (mean interval 5.8 months). There was no @entity3 and good ventricular function in all @entity0 . In addition to the @entity0 with the residual @entity6 , two other asymptomatic @entity0 had mild or moderate RVOTO. Compared with alternative surgical procedures for this @entity1 , anatomic correction has the advantages of acceptable operative mortality, use of the left ventricle as the systemic ventricle, no need for extracardiac conduits, and applicability to @entity0 with all variations of coronary artery and great artery anatomy.

title: Anatomic correction of @entity4 right ventricle with subpulmonary @entity6 (the " XXXX ).

answer: @entity4


abstract: Seven @entity0 with @entity4 right ventricle and subpulmonary @entity6 (the @entity4 ) underwent anatomical repair at the arterial level with transfer of the coronary arteries. At the time of operation, @entity0 ages ranged from 6 weeks to 33 months (mean 14.1 months) and weight ranged from 3.7 to 11.5 kg (mean 7.0 kg). Four @entity0 had prior pulmonary artery banding: Two of these four also had @entity5 repairs, and one had a Blalock-Hanlon septectomy. Three different patterns of coronary artery distribution were encountered. Five @entity0 had side-to-side great arteries, and two had more or less anteroposterior great arterial relationships. There was one operative @entity2 (14.3%: 70% confidence limits 1.9 - 40.7%) resulting from muscular subvalvular right ventricular outflow tract obstruction (RVOTO). There have been no late deaths in the six survivors followed 6 to 31 months postoperatively (mean 14.8 months). One @entity0 required closure of a residual @entity6 ( @entity6 ) and infundibular resection for RVOTO 4 months postoperatively. All other survivors are functionally NYHA Class I. Five of the six survivors have undergone postoperative catheterization (mean interval 5.8 months). There was no @entity3 and good ventricular function in all @entity0 . In addition to the @entity0 with the residual @entity6 , two other asymptomatic @entity0 had mild or moderate RVOTO. Compared with alternative surgical procedures for this @entity1 , anatomic correction has the advantages of acceptable operative mortality, use of the left ventricle as the systemic ventricle, no need for extracardiac conduits, and applicability to @entity0 with all variations of coronary artery and great artery anatomy.

title: Anatomic correction of @entity4 right ventricle with subpulmonary XXXX (the " @entity4 ).

answer: @entity6


abstract: Twenty-two @entity1 @entity0 and their spouses were studied. All @entity0 were living at home and had had a @entity1 at least one year previously. Of the 22 @entity0 14 were @entity0 and eight were @entity0 . Couples were assessed on the variables of morale, family functioning, health status, and @entity0 functional capacity. For all variables, @entity0 -spouse and husband-wife differences were tested. Couples from a previously studied random community sample were matched to the @entity1 couples on age and socioeconomic status (SES). Identical morale, family functioning, and health status data collected on these couples were compared to the @entity1 data. The results included the following: @entity1 @entity0 and their spouses were healthy on all variables. Members of the couple did not differ on most variables whether compared as husband-wife or @entity0 -spouse. Wives from the two samples did not differ on any variable. Husbands from the @entity1 sample differed from the matched husbands on only one health variable--the number of doctor visits made in the past six months.

title: XXXX : morale, family functioning, health status, and functional capacity.

answer: @entity1


abstract: The ultrastructure of the striated myocytes in the pulmonary myocardium of the @entity0 @entity0 , was studied following left @entity3 (LVI) for 4 days and 4 weeks, respectively. @entity1 was provided by ligating of the left coronary artery which successively produces @entity2 and congestion of the left atrium and pulmonary veins. In general, the striated myocytes of the extrapulmonary veins of the control groups displayed ultrastructural characteristics similar to those of the left atrium. However, in the former, transverse tubules commonly occurred making interior couplings with the SR at the I-band levels. Also, between striated myocytes of the intrapulmonary veins of the controls nexus-like junctions of about 2 micron length were observed. Further, in the same groups atrial specific granules (ASG), including A-granules and B-granules, were present in about 20%-30% of the striated myocytes of the extrapulmonary veins as shown in single sections. The ASG tended to decrease by number in areas approaching the lung hilus and were not observed in the intrapulmonary veins of the controls. After 4 days of @entity1 granules also appeared in the intrapulmonary veins. They were mostly seen in single and randomly spread in the cytoplasm of a limited number of cells, i.e., in between 0% and 5% of the myocytes as seen in single sections. Four days of LVI produced only minor cellular injuries to the extrapulmonary and intrapulmonary venous wall, while more severe lesions appeared in both areas following 4 weeks of LVI. Such lesions were preferably localized to the adluminal surface and consisted mainly of Z-band and sarcomere anomalies, vacuolization of the cytoplasm and mitochondrial swelling.

title: Striated myocytes and atrial specific granules in the pulmonary veins of chronically infarcted XXXX hearts.

answer: @entity0


abstract: One of the primary pathologies associated with @entity0 is a complex @entity2 with evidence of sympathetic @entity1 and/or vagal withdrawal. We investigated the possibility for early detection of essential @entity0 on the basis of the analysis of heart rate (HR) and blood pressure fluctuations, which reflect autonomic control. Young adult normotensive offspring of one @entity0 parent (KHT; n = 12) and normotensive offspring of two normotensive parents (YN; n = 14) participated in this study. ECG, continuous blood pressure, and respiration were recorded during steady-state conditions and under various autonomic challenges. Time-frequency decomposition of these signals was performed with the use of a continuous wavelet transform. The use of the wavelet transform enables the extension of typical HR variability analysis to non-steady-state conditions. This time-dependent spectral analysis of HR allows time-dependent quantification of different spectral components reflecting the sympathetic and parasympathetic activity during rapid transitions, such as an active @entity3 ( @entity3 ). During an active @entity3 from the supine to standing position, KHT demonstrated a significantly greater increase in the low-frequency fluctuations in HR than YN, indicating enhanced sympathetic involvement in the HR response to @entity3 , and a reduced alpha-index, indicating decreased baroreceptor sensitivity. On recovery from handgrip, vagal reactivation was more sluggish in KHT. These results indicate the early existence of malfunctions in both branches of autonomic control in individuals at increased risk of @entity0 .

title: Early autonomic malfunction in normotensive individuals with a genetic predisposition to essential XXXX .

answer: @entity0


abstract: @entity6 delivers the toxin ExoU to eukaryotic cells via a type III secretion system. Intoxication with ExoU is associated with @entity5 , @entity7 in animal model and @entity0 @entity2 . To search for ExoU targets in a genetically tractable system, we used controlled expression of the toxin in @entity3 . ExoU was cytotoxic for @entity3 and caused a @entity9 phenotype. Inhibitors of @entity0 @entity4 -independent ( @entity10 ) and cytosolic phospholipase A(2) (cPLA(2)) lipase activity reduce the @entity1 of ExoU. The catalytic domains of patatin, @entity10 and cPLA(2) align or are similar to ExoU sequences. Site-specific mutagenesis of predicted catalytic residues (ExoUS142A or ExoUD344A) eliminated @entity1 . ExoU expression in @entity3 resulted in an accumulation of free @entity8 , changes in the phospholipid profiles and reduction of radiolabeled neutral lipids. ExoUS142A and ExoUD344A expressed in @entity3 failed to release @entity8 . Recombinant ExoU demonstrated lipase activity in vitro, but only in the presence of a @entity3 extract. From these data we conclude that ExoU is a lipase that requires activation or modification by eukaryotic factors.

title: The mechanism of action of the XXXX -encoded type III cytotoxin, ExoU.

answer: @entity6


abstract: Previous publications have reported an unusually high @entity2 mortality rate for several Kentucky counties. We investigated these high rates by examining incidence of @entity1 in one county with a high mortality. The objective was to determine whether the incidence of @entity1 was as high as mortality rates indicated and, if so, to look for possible etiologic factors for the high rates. We found the incidence of @entity2 to be significantly higher in Campbell County than expected. While we expected 162 cases of @entity2 , we actually observed 192 (P less than .01). The number of @entity0 was no higher than expected (52 expected and 62 observed), in agreement with previously reported mortality figures. A geographic plot of cases by home residence showed a significantly higher rate of @entity2 for urban county regions than for rural regions. In fact, the population of rural Campbell County had a @entity2 rate significantly lower than either the county rate or the national rate. Several factors were analyzed to explain these rate differences. The only consistently associated factor was source of residential drinking water.

title: XXXX mortality and incidence in Campbell County, Kentucky.

answer: @entity1


abstract: @entity3 is often used to describe a brain insult. However, this approach assumes cortical equivalency and ignores the special importance that certain cortical regions have in the generation of behaviour. We hypothesized that incorporating knowledge of normal brain functional anatomy into the description of a motor @entity1 would provide an improved framework for understanding consequent behavioural effects. Anatomical scanning was performed in 21 @entity0 with a chronic @entity2 that involved the sensorimotor cortex. Functional MRI (fMRI) was used to generate separate average activation maps for four tasks including hand, shoulder and face motor tasks in 14 controls. For each task, group average maps for contralateral sensorimotor cortex activation were generated. Injury to these maps was measured by superimposing each @entity0 's @entity4 . These measurements were then correlated with behavioural assessments. In bivariate analyses, injury to fMRI maps correlated with behavioural assessments more strongly than total @entity4 volume. For example, performance on the Purdue pegboard test by the @entity2 -affected hand correlated with the fraction of hand motor map injured (r = -0.79) more strongly than with @entity4 volume (r = -0.60). In multiple linear regression analyses, measures of functional map injury, but not @entity4 volume, remained as significant explanatory variables for behavioural assessments. Injury to >37% of the hand motor map was associated with total loss of hand motor function. Hand and shoulder motor maps showed considerable spatial overlap (63%) and similar behavioural consequences of injury to each map, while hand and face motor maps showed limited overlap (10.4%) and disparate behavioural consequences of injury to each map. Lesion effects support current models of broad, rather than focal, sensorimotor cortex somatotopic representation. In the current cross-sectional study, incorporating an understanding of normal tissue function into lesion measurement provided improved insights into the behavioural consequences of focal @entity5 .

title: Improved understanding of XXXX by incorporating measures of functional anatomy.

answer: @entity3


abstract: PURPOSE: Initial response of intraocular @entity2 to chemotherapy has encouraged primary chemotherapy instead of primary enucleation for eyes with clinical features suggesting high risk of extraocular extension or @entity1 . Upfront enucleation of such high-risk eyes allows pathologic evaluation of extraocular extension, key to management with appropriate surveillance and adjuvant therapy. Does chemotherapy before enucleation mask histologic features of extraocular extension, potentially endangering the @entity0 's life by subsequent undertreatment? METHODS: We performed retrospective analysis of 100 eyes with advanced @entity2 enucleated with, or without, primary chemotherapy, in Beijing Tongren Hospital, retrospectively, from October 31, 2008. The extent of @entity2 invasion into optic nerve, uvea, and anterior chamber on histopathology was staged by pTNM classification. The treatment groups were compared for pathologic stage (Cochran-Armitage trend test) and disease-specific mortality (competing risks methods). RESULTS: @entity0 who received chemotherapy before enucleation had lower pTNM stage than primarily enucleated @entity0 (P = .01). Five @entity0 who received pre-enucleation chemotherapy died as a result of extension into brain or @entity1 . No @entity0 who had primary enucleation died. For @entity0 with group E eyes, disease-specific survival (DSS) was lower with pre-enucleation chemotherapy (n = 45) than with primary enucleation (n = 37; P = .01). Enucleation longer than 3 months after diagnosis was also associated with lower DSS (P < .001). CONCLUSION: Chemotherapy before enucleation of group E eyes with advanced @entity2 downstaged pathologic evidence of extraocular extension, and increased the risk of metastatic death from reduced surveillance and inappropriate management of high-risk disease, if enucleation was performed longer than 3 months after diagnosis.

title: Pre-enucleation chemotherapy for eyes severely affected by @entity2 masks risk of tumor extension and increases death from XXXX .

answer: @entity1


abstract: PURPOSE: Initial response of intraocular @entity2 to chemotherapy has encouraged primary chemotherapy instead of primary enucleation for eyes with clinical features suggesting high risk of extraocular extension or @entity1 . Upfront enucleation of such high-risk eyes allows pathologic evaluation of extraocular extension, key to management with appropriate surveillance and adjuvant therapy. Does chemotherapy before enucleation mask histologic features of extraocular extension, potentially endangering the @entity0 's life by subsequent undertreatment? METHODS: We performed retrospective analysis of 100 eyes with advanced @entity2 enucleated with, or without, primary chemotherapy, in Beijing Tongren Hospital, retrospectively, from October 31, 2008. The extent of @entity2 invasion into optic nerve, uvea, and anterior chamber on histopathology was staged by pTNM classification. The treatment groups were compared for pathologic stage (Cochran-Armitage trend test) and disease-specific mortality (competing risks methods). RESULTS: @entity0 who received chemotherapy before enucleation had lower pTNM stage than primarily enucleated @entity0 (P = .01). Five @entity0 who received pre-enucleation chemotherapy died as a result of extension into brain or @entity1 . No @entity0 who had primary enucleation died. For @entity0 with group E eyes, disease-specific survival (DSS) was lower with pre-enucleation chemotherapy (n = 45) than with primary enucleation (n = 37; P = .01). Enucleation longer than 3 months after diagnosis was also associated with lower DSS (P < .001). CONCLUSION: Chemotherapy before enucleation of group E eyes with advanced @entity2 downstaged pathologic evidence of extraocular extension, and increased the risk of metastatic death from reduced surveillance and inappropriate management of high-risk disease, if enucleation was performed longer than 3 months after diagnosis.

title: Pre-enucleation chemotherapy for eyes severely affected by XXXX masks risk of tumor extension and increases death from @entity1 .

answer: @entity2


abstract: We have reviewed 38 surgically treated cases of spontaneous @entity1 in 38 @entity0 with a mean age of 43 years (13 to 68) in order to identify clinical factors associated with its prognosis. Interfascicular neurolysis was performed at a mean of 13 months (1 to 187) after the onset of symptoms. The mean follow-up was 21 months (5.5 to 221). Medical Research Council muscle power of more than grade 4 was considered to be a good result. A further 12 cases in ten @entity0 were treated conservatively and assessed similarly. Of the 30 cases treated surgically with available outcome data, the result of interfascicular neurolysis was significantly better in @entity0 < 50 years old (younger group (18 nerves); good: 13 nerves (72%), poor: five nerves (28%)) than in cases > 50 years old (older group (12 nerves); good: one nerve (8%), poor: 11 nerves (92%)) (p < 0.001). A pre-operative period of less than seven months was also associated with a good result in the younger group (p = 0.01). The older group had a poor result regardless of the pre-operative delay. Our recommended therapeutic approach therefore is to perform interfascicular neurolysis if the @entity0 is < 50 years of age, and the pre-operative delay is < seven months. If the @entity0 is > 50 years of age with no sign of recovery for seven months, or in the younger group with a pre-operative delay of more than a year, we advise interfascicular neurolysis together with tendon transfer as the primary surgical procedure.

title: Surgical treatment of spontaneous XXXX : a retrospective study of 50 cases.

answer: @entity1


abstract: We previously reported that the long terminal repeats (LTRs) of retroviral elements belonging to the HERV-E family contribute to the expression of the @entity0 @entity3 ( @entity3 ) and endothelin B receptor ( @entity2 ) genes by providing alternative promoters. While both LTRs were shown to promote transcription in vivo and in vitro, their respective activity and tissue specificity appeared to differ even though they shared a high degree of sequence identity. In the present study, we further characterized the promoter of the @entity2 LTR and delineated the regions and motifs required for strong activity. We confirmed the placenta-restricted expression of the LTR by transient transfections and quantitative real-time PCR and determined that the retroviral promoter contributes significantly to the level of @entity2 transcripts in placenta, where chimeric mRNAs were found to represent 15% of overall @entity2 mRNAs. Transient transfection of 5' deletion constructs in cells of placental origin identified a motif, named LPE1, between positions 111 and 122 of the @entity2 LTR necessary for transcriptional activity. Removal of this region, which contains a putative SP1 binding site, abolished promoter activity. A second enhancing region resides between positions 175 and 215 of the LTR and was termed LPE2. Interestingly, this section contained three binding sites that were not present in the @entity3 LTR due to minor @entity1 differences. The predicted motifs in the @entity2 LTR were found to likely act in symbiosis as modifications to any of the three sites reduced transcription by one-third while alterations to all three eliminated promoter activity. The results from this study illustrate how slight variations in transcriptional regulatory sequences can have a profound effect on promoter activity and demonstrate the complex regulatory effects of @entity0 endogenous retrovirus elements on @entity0 gene expression.

title: Functional analysis of the endogenous retroviral promoter of the XXXX endothelin B receptor gene.

answer: @entity0


abstract: BACKGROUND: @entity0 overcrowding and violent assaults by @entity0 are two major problems in @entity1 healthcare. However, evidence of an association between overcrowding and @entity1 among @entity0 is mixed and limited to small-scale studies. AIMS: This study examined the association between ward overcrowding and violent physical assaults in acute-care @entity1 in- @entity0 hospital wards. METHOD: Longitudinal study using ward-level monthly records of bed occupancy and staff reports of the timing of violent acts during a 5-month period in 90 in- @entity0 wards in 13 acute @entity1 hospitals in Finland. In total 1098 employees (physicians, ward head nurses, registered nurses, licensed practical nurses) participated in the study. The outcome measure was staff reports of the timing of physical assaults on both themselves and ward property. RESULTS: We found that 46% of hospital staff were working in overcrowded wards, as indicated by >10 percentage units of excess bed occupancy, whereas only 30% of hospital personnel were working in a ward with no excess occupancy. An excess bed occupancy rate of >10 percentage units at the time of an event was associated with violent assaults towards employees (odds ratio (OR) = 1.72, 95% CI 1.05-2.80; OR = 3.04, 95% CI 1.51-6.13 in adult wards) after adjustment for confounding factors. No association was found with assaults on ward property (OR = 1.06, 95% CI 0.75-1.50). CONCLUSIONS: These findings suggest that @entity0 overcrowding is highly prevalent in @entity1 hospitals and, importantly, may increase the risk of violence directed at staff.

title: Overcrowding in XXXX wards and physical assaults on staff: data-linked longitudinal study.

answer: @entity1


abstract: A 77 year old right handed male was blind since the age of 2. He presented with an @entity4 involving the territory of the left middle cerebral artery involving the temporal and the inferior parietal lobes. He had learned to read and write language as well as read and write music in braille, ultimately becoming a famous organist and composer. There were no motor or sensory deficits. @entity2 with jargonaphasia, major difficulty in repetition, @entity7 and a significant @entity0 without @entity5 was present; verbal @entity6 and @entity3 in braille were also present. There was no evidence of @entity8 . He could execute in an exemplary fashion pieces of music for the organ in his repertory as well as improvise. All his musical capabilities: transposition, modulation, harmony, rythm, were preserved. The musical notation in braille remained intact: he could read by touch and play unfamiliar scores, he could also read and sing the musical notes, he could copy and write a score. Nine months after the @entity1 his aphasia remained unchanged. Nevertheless he composed pieces for the organ which were published. Such data highly suggest the independence of linguistic and musical competences, defined as the analysis and organization of sounds according to the rules of music. This independence in an extremely talented musician leads to a discussion of the role of the right hemisphere in the anatomical-functional processes at the origin of musical competence. The use of braille in which the same constellations of dots correspond either to letters of the alphabet or musical notes supports the independence between language and music.

title: [Aphasia without @entity8 in a blind organist. Verbal @entity6 - @entity3 without XXXX - @entity3 in braille].

answer: @entity6


abstract: A 77 year old right handed male was blind since the age of 2. He presented with an @entity4 involving the territory of the left middle cerebral artery involving the temporal and the inferior parietal lobes. He had learned to read and write language as well as read and write music in braille, ultimately becoming a famous organist and composer. There were no motor or sensory deficits. @entity2 with jargonaphasia, major difficulty in repetition, @entity7 and a significant @entity0 without @entity5 was present; verbal @entity6 and @entity3 in braille were also present. There was no evidence of @entity8 . He could execute in an exemplary fashion pieces of music for the organ in his repertory as well as improvise. All his musical capabilities: transposition, modulation, harmony, rythm, were preserved. The musical notation in braille remained intact: he could read by touch and play unfamiliar scores, he could also read and sing the musical notes, he could copy and write a score. Nine months after the @entity1 his aphasia remained unchanged. Nevertheless he composed pieces for the organ which were published. Such data highly suggest the independence of linguistic and musical competences, defined as the analysis and organization of sounds according to the rules of music. This independence in an extremely talented musician leads to a discussion of the role of the right hemisphere in the anatomical-functional processes at the origin of musical competence. The use of braille in which the same constellations of dots correspond either to letters of the alphabet or musical notes supports the independence between language and music.

title: [Aphasia without @entity8 in a blind organist. Verbal XXXX - @entity3 without @entity6 - @entity3 in braille].

answer: @entity6


abstract: A 77 year old right handed male was blind since the age of 2. He presented with an @entity4 involving the territory of the left middle cerebral artery involving the temporal and the inferior parietal lobes. He had learned to read and write language as well as read and write music in braille, ultimately becoming a famous organist and composer. There were no motor or sensory deficits. @entity2 with jargonaphasia, major difficulty in repetition, @entity7 and a significant @entity0 without @entity5 was present; verbal @entity6 and @entity3 in braille were also present. There was no evidence of @entity8 . He could execute in an exemplary fashion pieces of music for the organ in his repertory as well as improvise. All his musical capabilities: transposition, modulation, harmony, rythm, were preserved. The musical notation in braille remained intact: he could read by touch and play unfamiliar scores, he could also read and sing the musical notes, he could copy and write a score. Nine months after the @entity1 his aphasia remained unchanged. Nevertheless he composed pieces for the organ which were published. Such data highly suggest the independence of linguistic and musical competences, defined as the analysis and organization of sounds according to the rules of music. This independence in an extremely talented musician leads to a discussion of the role of the right hemisphere in the anatomical-functional processes at the origin of musical competence. The use of braille in which the same constellations of dots correspond either to letters of the alphabet or musical notes supports the independence between language and music.

title: [Aphasia without @entity8 in a blind organist. Verbal @entity6 - XXXX without @entity6 - @entity3 in braille].

answer: @entity3


abstract: A 77 year old right handed male was blind since the age of 2. He presented with an @entity4 involving the territory of the left middle cerebral artery involving the temporal and the inferior parietal lobes. He had learned to read and write language as well as read and write music in braille, ultimately becoming a famous organist and composer. There were no motor or sensory deficits. @entity2 with jargonaphasia, major difficulty in repetition, @entity7 and a significant @entity0 without @entity5 was present; verbal @entity6 and @entity3 in braille were also present. There was no evidence of @entity8 . He could execute in an exemplary fashion pieces of music for the organ in his repertory as well as improvise. All his musical capabilities: transposition, modulation, harmony, rythm, were preserved. The musical notation in braille remained intact: he could read by touch and play unfamiliar scores, he could also read and sing the musical notes, he could copy and write a score. Nine months after the @entity1 his aphasia remained unchanged. Nevertheless he composed pieces for the organ which were published. Such data highly suggest the independence of linguistic and musical competences, defined as the analysis and organization of sounds according to the rules of music. This independence in an extremely talented musician leads to a discussion of the role of the right hemisphere in the anatomical-functional processes at the origin of musical competence. The use of braille in which the same constellations of dots correspond either to letters of the alphabet or musical notes supports the independence between language and music.

title: [Aphasia without @entity8 in a blind organist. Verbal @entity6 - @entity3 without @entity6 - XXXX in braille].

answer: @entity3


abstract: A 77 year old right handed male was blind since the age of 2. He presented with an @entity4 involving the territory of the left middle cerebral artery involving the temporal and the inferior parietal lobes. He had learned to read and write language as well as read and write music in braille, ultimately becoming a famous organist and composer. There were no motor or sensory deficits. @entity2 with jargonaphasia, major difficulty in repetition, @entity7 and a significant @entity0 without @entity5 was present; verbal @entity6 and @entity3 in braille were also present. There was no evidence of @entity8 . He could execute in an exemplary fashion pieces of music for the organ in his repertory as well as improvise. All his musical capabilities: transposition, modulation, harmony, rythm, were preserved. The musical notation in braille remained intact: he could read by touch and play unfamiliar scores, he could also read and sing the musical notes, he could copy and write a score. Nine months after the @entity1 his aphasia remained unchanged. Nevertheless he composed pieces for the organ which were published. Such data highly suggest the independence of linguistic and musical competences, defined as the analysis and organization of sounds according to the rules of music. This independence in an extremely talented musician leads to a discussion of the role of the right hemisphere in the anatomical-functional processes at the origin of musical competence. The use of braille in which the same constellations of dots correspond either to letters of the alphabet or musical notes supports the independence between language and music.

title: [Aphasia without XXXX in a blind organist. Verbal @entity6 - @entity3 without @entity6 - @entity3 in braille].

answer: @entity8


abstract: OBJECTIVE: To review the epidemiology of @entity2 for @entity3 and the change of @entity0 characteristics over the last decade. DESIGN: Retrospective review. SETTING: A tertiary referral centre for joint replacement surgery in a teaching hospital in Hong Kong. @entity0 : All @entity0 who underwent primary @entity2 for primary @entity4 from January 2000 to December 2009. RESULTS: In all, 1157 total knee arthroplasties (589 left and 568 right) were performed on 588 females and 162 males. The annual number of total knee arthroplasties increased from 91 in 2000 to 181 in 2009. The annual number of @entity0 increased from 58 (46 female, 12 male) in 2000 to 159 (117 female, 42 male) in 2009. When compared yearly results, there were no significant changes in the preoperative Knee Society Knee Score, Knee Society Functional Assessment, and passive range of motion of these @entity0 . However, there was a significant decreasing trend with regard to lower limb mechanical axis mal-alignment, from 15.1   deviation from the neutral axis in 2000, to 14.8   deviation in 2004, and then 12.9   deviation in 2009 (mostly @entity1 ). There was no difference between left knees and right knees, and between females and males. The mean age of the @entity0 did not show significant change over the past decade, but the number and proportion of @entity0 over 80 years old showed an increase from 4.8% (2000 to 2004) to 13.8% (2005 to 2009). On the other hand, the number and proportion of @entity0 under the age of 60 years did not change. CONCLUSIONS: There was an increasing trend towards total knee arthroplasties, both in terms of number of operations and @entity0 . The number of younger @entity0 having @entity2 did not increase over the last 10 years, whereas the number of those older than 80 years increased significantly over that period.

title: Total knee arthroplasty for primary XXXX : changing pattern over the past 10 years.

answer: @entity4


abstract: OBJECTIVE: To compare the long-term outcome of open and laparoscopic surgery for Dukes' B and @entity2 in a regional hospital in Hong Kong. DESIGN: Retrospective study. SETTING: A regional hospital in Hong Kong. MAIN OUTCOME MEASURES: Survival and local recurrence rates. @entity0 : @entity0 with Dukes' B and C @entity2 underwent elective curative open or laparoscopic surgery during the period December 2000 to December 2006. RESULTS: A total of 222 @entity0 (open surgery, n=133; laparoscopic surgery, n=89) were assessed. The overall 3- and 5-year survival rates for all @entity0 were 72% and 58%, respectively. Local recurrence rates were similar in both groups. Laparoscopic group had better overall survival (P=0.014), however. The overall 3-year survival rates were 79% and 68% in the laparoscopic and open groups, respectively. The corresponding 5-year rates were 75% and 52%. Multivariate analysis also demonstrated that laparoscopic surgery was a significant independent factor for better survival. Chemotherapy, local recurrence, lymph node @entity1 , and poorly differentiated @entity2 were significantly associated with survival. CONCLUSION: Laparoscopic surgery for Dukes' B and @entity2 was associated with more favourable survival than with open surgery.

title: Clinical outcome of open and laparoscopic surgery in Dukes' B and XXXX : experience from a regional hospital in Hong Kong.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Many studies have investigated the association between the @entity2 ( @entity2 ) gene insertion/deletion (I/D) polymorphism and carotid artery @entity0 ( @entity0 ); however, most studies were small and conducted in selective samples. The aim of this study was to evaluate this association by performing a meta-analysis on published articles. METHODS: We searched Medline for articles studying the association between the @entity2 I/D polymorphism and carotid @entity0 . Twenty-six studies were found; 23 articles containing 9833 subjects were qualified to enter the meta-analysis. We classified those articles on the basis of their samples into high-risk and low-risk populations and white and Asian ethnic groups. @entity0 was used as a continuous variable, and data were analyzed with the Cochrane Review Manager. RESULTS: A significant positive association was present between the D allele and common carotid @entity0 (weighted mean difference between @entity1 and II genotypes, 0.23 mm x 10(-1); P<0.01). The association was stronger among high-risk populations. The point estimates of @entity1 versus II were higher than those of ID versus II. CONCLUSIONS: Our meta-analysis showed evidence of a positive association between the D allele of the @entity2 gene and common carotid @entity0 . The overall results were concordant in both ethnic groups.

title: XXXX gene polymorphism and carotid artery wall thickness: a meta-analysis.

answer: @entity2


abstract: STUDY DESIGN: A cross-sectional imaging study of young adults. OBJECTIVE: To evaluate whether severity of @entity3 predicts @entity2 in the paraspinal muscles of young adults. SUMMARY OF BACKGROUND DATA: Although an increased fat content of the lumbar muscles has been observed among adults with chronic @entity5 , there is limited knowledge of this association in younger populations. METHODS: The population-based study sample consisted of 554 subjects (321 females and 233 males) from the 1986 Northern Finland Birth Cohort. Latent Class Analysis (LCA) was used to cluster the subjects according to the @entity3 and functional limitations at 18, 19, and 21 years. The mean age of the subjects at the time of the MRI (magnetic resonance imaging) was 21 years (range, 20-23). @entity4 was evaluated by assessing the fat content of the paraspinal muscles using Opposed-Phase MRI. The cross-sectional areas (CSAs) of the erector spinae and multifidus muscles were also measured. RESULTS: LCA analysis produced five clusters differing in symptoms, ranging from a cluster (n = 65) in which subjects had high likelihood of symptoms and functional limitations at all time points, to a cluster (n = 165) with no @entity1 ever. The fat content of the multifidus muscles was significantly higher among @entity0 than @entity0 (14.0% vs. 5.3%, P < 0.001), but it was not significantly associated with symptom severity. The CSA of both erector spinae and multifidus muscles were significantly larger among @entity0 than @entity0 (P < 0.001 in all of the muscles), but were not associated with @entity1 severity. CONCLUSION: @entity3 and functional limitations over a 3-year period were not associated with increased fat content or a reduction in the cross-sectional area of lumbar paraspinal muscles among young adults.

title: Assessment of association between XXXX and @entity4 using opposed-phase magnetic resonance imaging: a population-based study among young adults.

answer: @entity3


abstract: STUDY DESIGN: A cross-sectional imaging study of young adults. OBJECTIVE: To evaluate whether severity of @entity3 predicts @entity2 in the paraspinal muscles of young adults. SUMMARY OF BACKGROUND DATA: Although an increased fat content of the lumbar muscles has been observed among adults with chronic @entity5 , there is limited knowledge of this association in younger populations. METHODS: The population-based study sample consisted of 554 subjects (321 females and 233 males) from the 1986 Northern Finland Birth Cohort. Latent Class Analysis (LCA) was used to cluster the subjects according to the @entity3 and functional limitations at 18, 19, and 21 years. The mean age of the subjects at the time of the MRI (magnetic resonance imaging) was 21 years (range, 20-23). @entity4 was evaluated by assessing the fat content of the paraspinal muscles using Opposed-Phase MRI. The cross-sectional areas (CSAs) of the erector spinae and multifidus muscles were also measured. RESULTS: LCA analysis produced five clusters differing in symptoms, ranging from a cluster (n = 65) in which subjects had high likelihood of symptoms and functional limitations at all time points, to a cluster (n = 165) with no @entity1 ever. The fat content of the multifidus muscles was significantly higher among @entity0 than @entity0 (14.0% vs. 5.3%, P < 0.001), but it was not significantly associated with symptom severity. The CSA of both erector spinae and multifidus muscles were significantly larger among @entity0 than @entity0 (P < 0.001 in all of the muscles), but were not associated with @entity1 severity. CONCLUSION: @entity3 and functional limitations over a 3-year period were not associated with increased fat content or a reduction in the cross-sectional area of lumbar paraspinal muscles among young adults.

title: Assessment of association between @entity3 and XXXX using opposed-phase magnetic resonance imaging: a population-based study among young adults.

answer: @entity4


abstract: BACKGROUND AND PURPOSE: There is a lack of systematic data regarding @entity1 ( @entity1 ) of thromboemboli occurring during @entity8 with the use of recombinant tissue plasminogen activator (rtPA). We report our technique for treating @entity1 of intracerebral thromboemboli occurring during @entity8 . METHODS: Nine of 723 @entity0 (1.2%) who underwent @entity8 during the period from January 1997 to September 2002 suffered @entity4 . These @entity0 were treated by @entity1 with a maximum dose of 0.9 mg rtPA per kilogram body weight. Recanalization was categorized as successful (Thrombolysis in @entity2 [TIMI] grade 2 or 3) versus unsuccessful (TIMI grade 0 or 1), and clinical outcome was categorized as independent (Rankin Scale score 0 to 2) versus dependent or dead (Rankin Scale score 3 to 6). RESULTS: The minimum time between @entity3 detection and beginning of @entity1 was 10 minutes, and the maximum time was 90 minutes. Successful recanalization was achieved in 4 of 9 @entity0 (44%). All 9 @entity0 suffered cerebral @entity5 , and none of the @entity0 sustained @entity6 . Two @entity0 (22%) died from malignant @entity7 . Four @entity0 (44%) remained moderately disabled, and 3 @entity0 (33%) were severely disabled 3 months after @entity1 . CONCLUSIONS: Although we used relatively high doses of rtPA, the recanalization rates and clinical outcome of @entity1 in our @entity0 were not satisfactory. Strategies for the prevention of thromboemboli during @entity8 must be improved, and novel fibrinolytic or thrombolytic techniques should be developed.

title: Local intra-arterial fibrinolysis of thromboemboli occurring during XXXX with recombinant tissue plasminogen activator.

answer: @entity8


abstract: The duration of therapy and outcome were examined in 76 @entity0 with @entity4 rheumatica without evidence of temporal @entity5 at presentation. Seventy-five @entity0 received @entity3 , with a mean @entity2 dosage of 22.8 mg per day initially. Duration of therapy was assessed using life-table methods. No significant difference could be ascertained between groups segregated on the basis of age, sex, or initial @entity1 dosage. The median duration of therapy was 37.3 months. It was estimated that 40 percent of @entity0 will require therapy longer than four years. @entity3 were permanently discontinued in 31 @entity0 after a mean of 23.7 months of therapy. The data support the concept of two @entity0 populations--one with limited disease and another requiring long-term therapy. Relapses were frequent, occurring in 56 percent of @entity0 . Evolution of @entity5 during the course of therapy was infrequent, occurring in only one @entity0 . @entity1 -related adverse effects occurred in 22.7 percent of @entity0 and were more common in females. The data suggest that, although @entity3 may be discontinued in some @entity0 with @entity4 rheumatica, prolonged therapy is required in a significant number.

title: XXXX rheumatica. Duration of therapy and long-term outcome.

answer: @entity4


abstract: A new surgical technique for thymectomy is presented. Three hundred and seventeen @entity0 with @entity4 and 20 with @entity3 who had @entity5 symptoms were operated on. The new surgical approach--a small transverse sternotomy--was used in 257 cases (in 240 @entity0 with @entity4 and 17 with @entity3 ) and conventional median sternotomy in 80. In @entity5 @entity0 small transverse sternotomy enabled radical thymectomy to be performed with an uneventful postoperative course and very good cosmetic results. There were no hospital deaths among @entity0 with @entity4 after thymectomy. The long term results, assessed after 18-24 months, were good: the total remission rate was 39.5%, and there was a great improvement in 48.5% and an improvement in 9%. After thymectomy about 30% of @entity0 received supplementary treatment with @entity2 . A correlation between the duration of symptoms and the result of thymectomy was established: the shorter the duration of @entity4 the better the results. In the small group of 20 @entity0 with @entity3 two died in hospital. In 12 @entity0 with encapsulated thymic @entity1 the long term results were similar to those in @entity0 with @entity4 , whereas in @entity0 with infiltrating thymic @entity1 the results were unsatisfactory.

title: Surgical treatment for XXXX .

answer: @entity4


abstract: In companion studies we have shown that chronic uremic male @entity1 are @entity5 and have lowered basal LH levels. Fertility was restored by either @entity0 @entity10 ( @entity10 ) or @entity6 treatment. Testicular steroidogenic responses to @entity10 in vivo and in vitro were normal or excessive, indicating that @entity9 was the predominant @entity3 in @entity7 . Further studies were undertaken to characterize the nature of the central defects in regulation of pituitary LH secretion. Uremic @entity1 have reduced MCRs for @entity1 LH (rLH) (61%), @entity1 FSH (rFSH) (47%), and LHRH (41%). Pituitary gonadotropin and hypothalamic LHRH content were unchanged in uremic @entity1 . Pituitary rLH and rFSH responses to LHRH stimulation in vivo and in vitro were quantitatively normal or excessive, with delayed peaks suggesting that uremic pituitary gonadotrope secretion is deficient due to lack of appropriate hypothalamic LHRH drive rather than intrinsic pituitary defects. Despite reduced pituitary gonadotropin secretion in intact uremic @entity1 , castration induced paradoxical excessive increases in pituitary LHRH binding, serum rLH, and rFSH beyond those of nonuremic controls. Paradoxical postcastration hyperresponses of serum rLH and rFSH were not due to circulating immunoreactive fragments of gonadotropins or undernutrition. Dysfunction of the @entity7 was further characterized in vivo by lack of rLH responsiveness to @entity8 and @entity2 to negative testicular feedback in castrate- @entity4 -replaced and intact @entity1 . These data demonstrate that @entity7 is principally due to aberrant hypothalamic regulation of pituitary LH secretion resembling those of the immature @entity1 or seasonally regressed animal. This recrudescence of the inactive regulatory state in a disease model suggests that common mechanisms are operative in orderly gonadal withdrawal under hostile or inappropriate environments and may underly the reversibility of @entity0 @entity7 with successful renal transplantation.

title: Hypothalamic-pituitary function in experimental XXXX .

answer: @entity7


abstract: @entity5 ( @entity2 ) has a profound and rapid influence on the cytoskeleton of Madin-Darby @entity1 Kidney (MDCK) cells. Within 10 min, @entity2 induces a rapid change in morphology, from a flat, cuboidal state to a rounded or elongated morphology in which the cell membranes become convoluted. Concomitant with this morphological change is a rapid dissolution of stress fibres and a redistribution of F-actin from microfilament bundles to a membrane or sub-membranous location. The rearrangement of actin is paralleled by a rearrangement of alpha-actinin and a reduction in the number of @entity6 -containing adhesion plaques. Unusual F-actin configurations are often found emanating from a perinuclear location, usually containing alpha-actinin and terminating in a @entity6 -containing adhesion plaque. The cytoskeletal rearrangements occur in the presence of inhibitors of protein synthesis or oxidative phosphorylation, but do not occur if glycolysis is also inhibited. The rearrangements are partly abrogated by the presence of @entity3 (CB). Despite these dramatic changes in microfilaments the polymerization state of actin remained unaltered after @entity2 treatment. Furthermore, although changes in the movement of membrane lipids have been reported, no obvious differences in the ability of glycoproteins to redistribute in the plane of the membrane were found as judged by @entity4 -concanavalin A (conA) induced patching. The rapidity of the morphological response of MDCK cells to @entity2 indicates that the cytoskeleton is one of the primary targets of @entity2 , but that @entity0 promoters differ from RNA @entity0 viruses in their effect on the state of actin polymerization.

title: Interaction of XXXX promoters with epithelial cells in culture. An immunofluorescence study.

answer: @entity0


abstract: The @entity3 , an established model of @entity5 , was used to study hematologic and hemostatic aspects of @entity5 and whether Mopeia (also known as Mozambique) virus induces any cellular damage in this model. Six days after subcutaneous injection of 10(3.48) plaque forming units (PFU) of @entity6 (Josiah strain) one group of monkeys received an intravenous injection of 111In-labeled allogeneic platelets and another group received 125I-labeled alogeneic @entity2 . @entity6 -infected monkeys developed a severe @entity1 and typical pathology. Lassa antigen was found in most tissues using a Lassa nucleocapsid-specific monoclonal antibody. Platelet counts remained within normal limits. Platelet and @entity2 kinetics were similar in infected and control animals. Hematologic and hemostatic changes indicate that disseminated @entity4 plays no role in this model of @entity5 . Levels of plasma fibronectin were reduced in Lassa-infected monkeys. Mopeia virus-infected monkeys were normothemic, aviremic, and there was no detection of Mopeia antigen in any tissues using polyclonal or monoclonal antibodies. Mopeia virus was recovered from the spleen of one monkey. Mopeia virus was associated with hepatocellular and @entity0 .

title: Kinetic study of platelets and @entity2 in XXXX -infected monkeys and early pathologic events in Mopeia virus-infected monkeys.

answer: @entity6


abstract: The @entity3 , an established model of @entity5 , was used to study hematologic and hemostatic aspects of @entity5 and whether Mopeia (also known as Mozambique) virus induces any cellular damage in this model. Six days after subcutaneous injection of 10(3.48) plaque forming units (PFU) of @entity6 (Josiah strain) one group of monkeys received an intravenous injection of 111In-labeled allogeneic platelets and another group received 125I-labeled alogeneic @entity2 . @entity6 -infected monkeys developed a severe @entity1 and typical pathology. Lassa antigen was found in most tissues using a Lassa nucleocapsid-specific monoclonal antibody. Platelet counts remained within normal limits. Platelet and @entity2 kinetics were similar in infected and control animals. Hematologic and hemostatic changes indicate that disseminated @entity4 plays no role in this model of @entity5 . Levels of plasma fibronectin were reduced in Lassa-infected monkeys. Mopeia virus-infected monkeys were normothemic, aviremic, and there was no detection of Mopeia antigen in any tissues using polyclonal or monoclonal antibodies. Mopeia virus was recovered from the spleen of one monkey. Mopeia virus was associated with hepatocellular and @entity0 .

title: Kinetic study of platelets and XXXX in @entity6 -infected monkeys and early pathologic events in Mopeia virus-infected monkeys.

answer: @entity2


abstract: The present study examined the phenomenon of acclimatization in @entity0 with a severe-to-profound @entity1 . A secondary purpose was to examine the efficacy of a digital nonlinear power hearing aid that has a low compression threshold with expansion for this population. Twenty experienced hearing aid users wore the study hearing aids for three months and their performance with the study hearing aids was evaluated at the initial fitting, one month, and three months after the initial fitting. Performance of their current hearing aids was also evaluated at the initial fitting. Speech recognition testing was conducted at input levels of 50 dB @entity2 and 65 dB @entity2 in quiet, and 75 dB @entity2 in noise at a +10 SNR. Questionnaires were used to measure subjective performance at each evaluation interval. The results showed improvement in speech recognition score at the one-month evaluation over the initial evaluation. No significant improvement was seen at the three-month evaluation from the one-month visit. In addition, subjective and objective performance of the study hearing aids was significantly better than the @entity0 ' own hearing aids at all evaluation intervals. These results provided evidence of acclimatization in @entity0 with a severe-to-profound @entity1 and reinforced the precaution that any trial of amplification, especially from linear to nonlinear mode, should consider this phenomenon.

title: Evidence of acclimatization in @entity0 with severe-to-profound XXXX .

answer: @entity1


abstract: The present study examined the phenomenon of acclimatization in @entity0 with a severe-to-profound @entity1 . A secondary purpose was to examine the efficacy of a digital nonlinear power hearing aid that has a low compression threshold with expansion for this population. Twenty experienced hearing aid users wore the study hearing aids for three months and their performance with the study hearing aids was evaluated at the initial fitting, one month, and three months after the initial fitting. Performance of their current hearing aids was also evaluated at the initial fitting. Speech recognition testing was conducted at input levels of 50 dB @entity2 and 65 dB @entity2 in quiet, and 75 dB @entity2 in noise at a +10 SNR. Questionnaires were used to measure subjective performance at each evaluation interval. The results showed improvement in speech recognition score at the one-month evaluation over the initial evaluation. No significant improvement was seen at the three-month evaluation from the one-month visit. In addition, subjective and objective performance of the study hearing aids was significantly better than the @entity0 ' own hearing aids at all evaluation intervals. These results provided evidence of acclimatization in @entity0 with a severe-to-profound @entity1 and reinforced the precaution that any trial of amplification, especially from linear to nonlinear mode, should consider this phenomenon.

title: Evidence of acclimatization in XXXX with severe-to-profound @entity1 .

answer: @entity0


abstract: The effects of @entity2 on renal hemodynamics under both normovolemic and @entity3 conditions were investigated in chronically instrumented conscious @entity0 whose homeostatic mechanisms were not altered by the presence of preexisting drugs. Renal blood flow and aortic pressure were assessed by prior implantation of Doppler ultrasonic flow probes on the renal artery and a catheter in the descending aorta. Administration of @entity2 to conscious normovolemic @entity0 (Group HN) resulted in 11-26% decreases in renal vascular resistance with no significant changes occurring in renal blood flow. In a second group of animals made @entity3 while awake (Group AH), 30% of the blood volume was removed over one-half hour. In response to @entity1 , these conscious animals' renal blood flow did not significantly change from the normovolemic control, and renal vascular resistance significantly decreased. With no further intervention, renal vascular resistance and renal blood flow remained unchanged from the level achieved after the 30% @entity1 . A third group of animals (Group HH) was hemorrhaged in a manner similar to that of Group AH. They also showed no significant changes in renal blood flow and a significant decrease in renal vascular resistance in response to @entity1 . Thereafter, administration of @entity2 , as in Group HN, to this group produced 11-23% decreases in renal vascular resistance with no significant decline in renal blood flow from the @entity3 control levels established after @entity1 . The author concludes the following: administration of @entity2 to normovolemic conscious @entity0 does not decrease renal blood flow; a moderate degree of @entity1 does not decrease renal blood flow in conscious @entity0 ; and administration of @entity2 to acutely @entity3 conscious @entity0 does not impair renal perfusion.

title: Effect of @entity2 on renal hemodynamics during normovolemia and XXXX .

answer: @entity1


abstract: The effects of @entity2 on renal hemodynamics under both normovolemic and @entity3 conditions were investigated in chronically instrumented conscious @entity0 whose homeostatic mechanisms were not altered by the presence of preexisting drugs. Renal blood flow and aortic pressure were assessed by prior implantation of Doppler ultrasonic flow probes on the renal artery and a catheter in the descending aorta. Administration of @entity2 to conscious normovolemic @entity0 (Group HN) resulted in 11-26% decreases in renal vascular resistance with no significant changes occurring in renal blood flow. In a second group of animals made @entity3 while awake (Group AH), 30% of the blood volume was removed over one-half hour. In response to @entity1 , these conscious animals' renal blood flow did not significantly change from the normovolemic control, and renal vascular resistance significantly decreased. With no further intervention, renal vascular resistance and renal blood flow remained unchanged from the level achieved after the 30% @entity1 . A third group of animals (Group HH) was hemorrhaged in a manner similar to that of Group AH. They also showed no significant changes in renal blood flow and a significant decrease in renal vascular resistance in response to @entity1 . Thereafter, administration of @entity2 , as in Group HN, to this group produced 11-23% decreases in renal vascular resistance with no significant decline in renal blood flow from the @entity3 control levels established after @entity1 . The author concludes the following: administration of @entity2 to normovolemic conscious @entity0 does not decrease renal blood flow; a moderate degree of @entity1 does not decrease renal blood flow in conscious @entity0 ; and administration of @entity2 to acutely @entity3 conscious @entity0 does not impair renal perfusion.

title: Effect of XXXX on renal hemodynamics during normovolemia and @entity1 .

answer: @entity2


abstract: Shunting of portal blood in the @entity0 leads to @entity2 and to an increase in arterial blood flow with microcirculatory disturbances. The aim of this study was to investigate the effects of these disturbances on the liver sinusoidal barrier (endothelial and @entity4 ) using morphometric techniques. @entity0 with @entity1 ( @entity1 ) and sham operated pair-fed controls were studied 3 months after the shunt. Sinusoidal volume density in @entity1 increased but not significantly and the volume density (Vv) of total endothelial (EC) and @entity4 ( @entity4 ) increased by 104.54% compared to sham operated pair-fed @entity0 . The increase of EC Vv was not associated with an increase in surface density (Sv) suggesting a fall in the number of small fenestrations and an increase in cell thickness. This interpretation supports the morphological observations. The increase of @entity4 Vv was mainly related to the increase in their subendothelial processes Vv and not to that of the cell body Vv. Lipids Vv and RER Sv expressed per sinusoidal cells remained unchanged suggesting that the balance between the 2 hypothetical functions of the @entity4 , namely fibrogenesis and storage of @entity3 , was maintained. In conclusion, changes of EC and @entity4 after @entity1 result mainly in thickening of the sinusoidal barrier. This increase may impair exchanges between the sinusoidal lumen and Disse space and contribute to functional abnormalities.

title: The sinusoidal barrier in @entity0 with XXXX : a morphometric study.

answer: @entity1


abstract: Shunting of portal blood in the @entity0 leads to @entity2 and to an increase in arterial blood flow with microcirculatory disturbances. The aim of this study was to investigate the effects of these disturbances on the liver sinusoidal barrier (endothelial and @entity4 ) using morphometric techniques. @entity0 with @entity1 ( @entity1 ) and sham operated pair-fed controls were studied 3 months after the shunt. Sinusoidal volume density in @entity1 increased but not significantly and the volume density (Vv) of total endothelial (EC) and @entity4 ( @entity4 ) increased by 104.54% compared to sham operated pair-fed @entity0 . The increase of EC Vv was not associated with an increase in surface density (Sv) suggesting a fall in the number of small fenestrations and an increase in cell thickness. This interpretation supports the morphological observations. The increase of @entity4 Vv was mainly related to the increase in their subendothelial processes Vv and not to that of the cell body Vv. Lipids Vv and RER Sv expressed per sinusoidal cells remained unchanged suggesting that the balance between the 2 hypothetical functions of the @entity4 , namely fibrogenesis and storage of @entity3 , was maintained. In conclusion, changes of EC and @entity4 after @entity1 result mainly in thickening of the sinusoidal barrier. This increase may impair exchanges between the sinusoidal lumen and Disse space and contribute to functional abnormalities.

title: The sinusoidal barrier in XXXX with @entity1 : a morphometric study.

answer: @entity0


abstract: Surgical management of squamous cell @entity3 continues to be a controversial area in thoracic surgery. In a series of 20 @entity0 , 15 received preoperative chemotherapy with cis- @entity5 ( @entity4 ), 2 received @entity4 plus @entity6 , and 3 received @entity4 plus @entity9 . Eighteen @entity0 underwent en bloc esophagogastrectomy and postoperative radiation therapy. All @entity0 were staged preoperatively by thoracoabdominal computed axial tomographic scan, bone scan, bronchoscopy, esophagoscopy, and barium swallow. @entity0 with liver or bone @entity1 were excluded. The majority of @entity0 received preoperative @entity7 . Eighteen of the 20 @entity0 completed the study with a follow-up of 12 to 24 months. There was 1 operative death, and 3 @entity0 were in the hospital for more than three weeks after operation before they were discharged. Fourteen of the 18 @entity0 survived for a year, and 11 survived for 12 to 24 months. @entity8 and @entity2 burden based on preoperative barium swallow and endoscopy was evident in 11 of 18 @entity0 , but in no @entity0 was the @entity2 completely eradicated by preoperative chemotherapy. Although follow-up is short, this treatment regimen involving a combined treatment offers hope in the palliation of this disease.

title: Combined treatment approach in surgical management of XXXX : a preliminary report.

answer: @entity3


abstract: UNASSIGNED: The presence of @entity2 is one of the most important criteria for @entity1 diagnosis and management. @entity0 @entity1 is a rare disease that affects @entity0 in their first year of life. It has been estimated that approximately one third of @entity0 with @entity3 harbour the t(7;12)(q36;p13) rearrangement in their leukaemic blasts. However, the WHO classification of @entity3 does not yet include the t(7;12) as a separate entity among the different genetic subtypes, although the presence of this @entity2 has been associated with an extremely poor clinical outcome. Currently, there is no consensus treatment for t(7;12) @entity1 @entity0 . However, with the inferior outcome with the standard induction therapy, stem cell transplantation may offer a better chance for disease control. A better insight into the chromosome biology of this entity might shed some light into the pathogenic mechanisms arising from this chromosomal translocation, that at present are not fully understood. Further work is needed to improve our understanding of the molecular and genetic basis of this disorder. This will hopefully open some grounds for possible tailored treatment for this subset of very young @entity0 with inferior disease outcome. This review aims at highlighting the cytogenetic features that characterise the @entity1 for a better detection of the abnormality in the diagnostic setting. We also review treatment and clinical outcome in the cases reported to date.

title: Paediatric XXXX with the t(7;12)(q36;p13) rearrangement: a review of the biological and clinical management aspects.

answer: @entity3


abstract: We studied sputum @entity4 concentrations after intravenous administration in 10 @entity3 @entity0 . @entity4 concentrations were determined by a bioassay and a radioenzymatic assay (REA). The bacterial density of @entity2 in sputum was examined serially during therapy. Bioactivity of @entity4 in the sputum was low and increased little during treatment. In contrast, @entity4 content (as assayed by REA) showed a progressive accumulation of the drug to high concentrations: a mean of 82 micrograms/g sputum after 3 wk of therapy in 4 @entity0 . @entity2 was eradicated from the sputum in 3 of 4 patients receiving antibiotic therapy for 3 wk. Eradication correlated with @entity4 sputum concentrations measured by REA, which were 20-fold greater than the apparent @entity4 inhibitory concentration. A bactericidal effect of @entity1 in the presence of sputum in vitro could only be reliably produced with concentrations 25-fold the MIC. We conclude that @entity4 penetrates @entity3 ( @entity3 ) sputum and accumulates over time. Although @entity3 sputum antagonized the bioactivity of @entity1 , 3 wk of intravenous therapy combined with an antipseudomonal @entity5 antibiotic may be effective in eradication of @entity2 from sputum of certain @entity3 @entity0 .

title: Aminoglycoside penetration, inactivation, and efficacy in XXXX sputum.

answer: @entity3


abstract: UNASSIGNED: Background. @entity5 plays a key role in the handling of lipoprotein particles with @entity5 and @entity5 frequently having opposite effects compared to @entity5 . Some individuals simultaneously carry both E2 and E4 alleles. The impact of the @entity5 /4 genotype on lipid concentrations and its consequences on health remain poorly documented. Objective. This study compared the lipid profile between @entity5 /4 carriers and other @entity5 genotypes in relation to the waist circumference. Methods. @entity1 , @entity2 (TG), and @entity3 concentrations were measured among 2,680 Caucasians. Multivariate logistic regression models were used to estimate the contribution of @entity5 /4 to various dyslipidemic profiles associated with @entity4 . Results. In presence of @entity4 , the lipid profile was as deteriorated in @entity5 /4 carriers as in carriers of other @entity5 genotypes. There was a more pronounced effect on TG-rich lipoproteins, particularly in @entity5 (a feature of @entity6 ), and non-high-density lipoprotein (HDL) @entity1 in @entity5 /4. Compared to @entity5 , @entity5 /4 carriers presented lower very-low-density lipoprotein (VLDL) @entity1 concentrations and VLDL- @entity1 /TG ratios, with or without @entity0 , and higher low-density lipoprotein (LDL) @entity1 concentrations. Conclusion. In presence of @entity4 , the influence of the @entity5 allele could be less pronounced than that of @entity5 among @entity5 /4 individuals.

title: Influence of XXXX on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality.

answer: @entity4


abstract: BACKGROUND: Multi-drug resistant (MDR) Enterobacteriaceae are on the increase worldwide and their spread has become a global challenge. Escalating the challenge is the possibility that many of these are Carbapenemase-producing Enterobacteriaceae (CPE). This further complicates @entity0 management. The magnitude of MDR-CPE in many developed settings has been reported, however, there is paucity of data from resource limited settings. We evaluated the epidemiology of MDR-CPE of clinical origin in South Western Uganda. METHODS: From September 2013 to June 2014, all Enterobacteriaceae isolated from diverse specimens obtained from @entity0 attending Mbarara Regional Referral Hospital, South-western Uganda, were screened for MDR in a laboratory-based cross sectional study. Isolates found to be MDR were screened for @entity4 susceptibility/resistance phenotypically by Kirby Bauer disc diffusion method following CLSI guidelines and genetically using the multiplex real-time Polymerase Chain Reaction (RT-PCR). RESULTS: Of the 658 strains isolated, 183 (27.8%) were MDR and 68 (37.15%) of those MDR exhibited at least one form of @entity4 resistance with 23 (12.57%) and 56 (30.60%) isolates expressing phenotypic and genetic resistance, respectively. Eleven MDR-CPE (6.01%) isolates exhibited both phenotypic and genotypic resistance to @entity3 . Only bla @entity2 and bla OXA-48 genes were detected among the genetically resistant isolates. CONCLUSION: The high prevalence of MDR-CPE calls for @entity1 control and prevention strategies, including reinforcement of hand hygiene, using contact precautions and early detection of CPE through use of targeted surveillance and molecular techniques in resource limited settings.

title: Epidemiology of XXXX Resistance among Multi-drug Resistant Enterobacteriaceae in Uganda.

answer: @entity4


abstract: OBJECTIVE: To investigate changes in the core temperature and body surface temperature in @entity0 with incomplete @entity2 ( @entity2 ). In incomplete @entity2 , the temperature change is difficult to see compared with complete @entity2 . The goal of this study was to better understand thermal regulation in @entity0 with incomplete @entity2 . METHODS: Fifty-six @entity2 @entity0 were enrolled, and the control group consisted of 20 healthy @entity0 . The @entity2 were classified according to International Standards for Neurological Classification of @entity2 . The @entity0 were classified into two groups: upper ( @entity1 or above) and lower ( @entity1 level T7 or below) SCIs. Body core temperature was measured using an oral thermometer, and body surface temperature was measured using digital infrared thermographic imaging. RESULTS: Twenty-nine @entity0 had upper @entity2 , 27 @entity0 had lower SCIs, and 20 @entity0 served as the normal healthy @entity0 . Comparing the skin temperatures of the three groups, the temperatures at the lower abdomen, anterior thigh and anterior tibia in the @entity0 with upper SCIs were lower than those of the normal healthy @entity0 and the @entity0 with lower SCIs. No significant temperature differences were observed between the normal healthy @entity0 and the @entity0 with lower SCIs. CONCLUSION: In our study, we found thermal dysregulation in @entity0 with incomplete @entity2 . In particular, body surface temperature regulation was worse in upper SCIs than in lower injuries. Moreover, cord injury severity affected body surface temperature regulation in @entity2 @entity0 .

title: Changes in Body Temperature in Incomplete XXXX by Digital Infrared Thermographic Imaging.

answer: @entity2


abstract: INTRODUCTION: Platelet Rich Plasma (PRP) contains numerous growth factors; @entity2 ( @entity2 ) is plasma proteins without platelets, containing growth factors other than platelet derived. We planned to evaluate the effect of both autologous PRP _ @entity2 on @entity0 ACL cell growth characteristics in culture conditions to see if one was better than the other. METHODS: ACL remnants were collected from eleven @entity0 during ACL reconstruction surgery; @entity2 and PRP were prepared from blood of these @entity0 . Cells were isolated, identified and cultured and were then divided into six groups. Groups A-D had @entity3 ( @entity3 ) added to them along with different concentrations of PRP and @entity2 . Groups E and F had 5% and 10% PRP respectively but lacked @entity3 . Cell viability was assayed by @entity1 and @entity5 assay, and DNA content was evaluated by @entity4 staining and flow cytometry. RESULTS: analysis of cultured cells showed that addition of PRP (5 or 10%) increased the viability of ACL cells in 4 out of 11 and promoted cell proliferation in 8 of 11 donor samples; 10% PRP was more effective than 5% PRP. However, the difference in effectiveness of 10% PRP was not significantly better than 5% PRP. 5% @entity2 had no significant effect on cell viability, but it led to an increase in DNA content in 5 of 11. There was no statistically significant effect of either PRP or @entity2 in preventing cell death (depicted by apoptosis rate). CONCLUSION: PRP may have an enhancing effect on ACL cell viability and promotion of cell proliferation but the ideal concentration of PRP for these positive effects needs to be determined before it could be used in clinical settings for enhancing primary repair of torn ACL. Also larger, more controlled and better studies are needed to confirm its clinical utility.

title: Can Platelet rich plasma stimulate XXXX ACL growth in culture? A preliminary experience.

answer: @entity0


abstract: INTRODUCTION: management of intrasubstance @entity2 is still controversial. Intrasubstance @entity2 can lead to reduced sports activity and @entity4 . Physical therapy is often not satisfactory. Therefore new treatment methods are requested. Platelet Rich Plasma (PRP) has the ability to regenerate tissue; this was proved in several experimental studies. Whether percutaneous injections of PRP are effective in intrasubstance @entity2 is unknown. We hypothesize that percutaneous PRP injections lead to @entity3 relief and halt of progression on MRI over 6 months in @entity0 with grade 2 @entity2 . MATERIALS AND METHODS: ten recreational athletes with intrasubstance @entity2 (grade II according to Reicher) proven by MR-Imaging (MRI) were treated by percutaneous injections of PRP in the affected meniscal area. Three sequential injections in seven day intervals were performed in every @entity0 . All injections were performed with image converter. Follow-up MRI was done six months after last injection in every @entity0 . Level of sports activity and amount of @entity3 at athletic loads according to numeric rating scale (NRS-11) were noted in each @entity0 before injections and at the time of follow up MRI after six months. The t-test was used to determine statistical differences. RESULTS: four of ten @entity0 (40%) showed @entity1 in follow up MRI after six months. Nine of ten @entity0 (90%) complained about short episodes of @entity3 after the injections with average NRS-Score of 7.9 at daily loads after the last injection. Six of ten @entity0 (60%) showed Improvement of NRS-Score at final follow up. Average NRS-Score improved significantly (p=0.027) from 6.9 before injections to 4.5 six month after treatment. Six of ten @entity0 (60%) reported increase of sports activity compared to the situation before injections. In four @entity0 (40%) additional surgical treatment was necessary because of persistent knee @entity3 or progression of @entity2 . CONCLUSIONS: percutaneous injections of PRP have the ability to achieve @entity3 relief and halt of progression on MRI over 6 months in @entity0 with grade 2 @entity2 . Therefore it could be considered as a treatment option in @entity0 with persisting @entity3 . LEVEL OF EVIDENCE: IV.

title: Percutaneous injections of Platelet rich plasma for treatment of intrasubstance XXXX .

answer: @entity2


abstract: BACKGROUND: Recent studies suggest aggressive management combining a grossly total resection (GTR) with adjuvant radiotherapy (RT) as a treatment of choice for @entity4 ( @entity6 ). However, in these papers, the definitions of complete or GTR are equivocal. In the present study, we reviewed the relevant cases from our experience focused on the clinical efficacy of surgical grading of resection, and analyzed the optimal treatment strategies as well. METHODS: From January 1995 through December 2014, 17 @entity0 treated for intracranial @entity6 were included in this study. We analyzed clinical presentation, radiologic appearance, pathologic diagnosis, extent of resection, and follow-up outcomes. RESULTS: A total of 26 operations were performed including 9 recurrent intracranial HPCs. Every @entity2 was single and had no evidence of @entity1 . Most common area of @entity2 was parasagittal (8 @entity0 , 47.1%), which is adjoined to superior sagittal sinus. For the initial operation, GTR was performed in 16 cases (61.5%), partial resection (PR) in 8 cases (30.8%), and an endoscopic biopsy in 2 @entity0 (7.7%). In Simpson grading system, grade 1 was done in 2 @entity0 (7.7%), grade 2 in 11 @entity0 (42.3%) and grade 3 in 3 @entity0 (11.5%). @entity3 was delivered in 16 @entity0 (94.1%) regardless of the extent of resection. The median 57.57 Gy (range, 50-60 Gy) was delivered in median 33 fractions (range, 30-40). The extent of resection (conventional classification and Simpson grading system) and adjuvant RT were significantly associated with recurrence-free survival. CONCLUSION: Surgical resection of intracranial @entity6 , in an attempt to reach Simpson grade 1 removal, is necessary for better outcome. @entity5 should be done as recommended before, to prevent recurrence, regardless of surgical resection and pathological diagnosis.

title: Treatment Strategy of Intracranial XXXX .

answer: @entity6


abstract: The aim of the study was to investigate the significance of @entity1 (added to food of the @entity0 ) for contractility of smooth muscles (effected by @entity2 ) and ultrastructure of their microfilaments in case of hypodynamic stress. Hypodynamic stress of 48-day duration was provoked for Chinchilla @entity0 (n=20) by placing them in metal hutches. Every day (48 days) 10 @entity0 , which had intervention received doses of @entity1 0.3 mg/kg body wt (in form of @entity4 ). The @entity0 (n=10) of the control group, which had no intervention were kept in vivarium conditions. The relaxation of smooth muscles from thoracic aorta as mediated by @entity2 at a concentration from 10(-8) mol/l to 10(-4) mol/l was detected by means of a 6MXIC mechanotron in isometric regime. Response was expressed as the percentage of relaxation to @entity3 (10(-5) mol/l)-induced precontraction. The ultrastructure of the microfilaments of smooth muscles was evaluated by electron microscopy "Philips-300". In @entity0 that received no @entity1 the relaxation of smooth muscles under the influence of @entity2 was significantly lower than in @entity0 that received @entity1 and lower in control @entity0 . Also in @entity0 without @entity1 supplement the investigation of ultrastructure of microfilaments revealed their damage (such change as irregular formation, drop out in flakes, microfilaments becoming shorter and thicker). In @entity0 receiving @entity1 ultrastructure of microfilaments did not change.

title: [The significance of XXXX for contractility of smooth muscles and ultrastructure of their microfilaments in case of hypodynamic stress].

answer: @entity1


abstract: BACKGROUND: To evaluate the predictability of refraction following immediate sequential bilateral @entity1 surgery (ISBCS) performed under general anaesthesia. METHODS: This is a retrospective review of all ISBCS performed at Kantonsspital Winterthur, Switzerland, between April 2000 and September 2013. The case notes of 250 @entity0 were reviewed. @entity0 having full refraction reported (110 @entity0 /220 eyes) were included. 210 (95  %) eyes had a straight forward phacoemulsification with posterior chamber @entity2 implantation, seven eyes had a planned extracapsular @entity1 extraction (ECCE); three eyes had an intracapsular @entity1 extraction. RESULTS: Both eyes of 110 @entity0 (64 @entity0 , 46 @entity0 ) with a mean age of 79.0  years, standard deviation (SD)   11.4 (range 26 to 97  years) were included. Median preoperative best corrected visual acuity (BCVA) was 0.5 LogMAR in the first eye, the interquartile range (IQR) was [0.4, 1.2]; 0.7 LogMAR in the second eye with IQR [0.4, 1.8]. At one month, the median BCVA was 0.2 LogMAR, IQR [0.1, 0.3] in the first eye, median BCVA was 0.1 LogMAR and IQR [0.0, 0.5] in the second eye. There were 3 eyes (3  %) that lost 3 lines or more in BCVA at one month (control vs. pre-operatively). In all three cases, poor visual acuity had been recorded pre-operatively (>1 LogMAR). Achieved refraction was within   1.0 D of the target in 83  % of eyes. There were only 5  % (n   =   6) of cases where if delayed sequential bilateral extraction had been performed could potentially @entity2 ( @entity2 ) choice have been adjusted, in four of these cases, target refraction was within   1.0 D in the second eye. CONCLUSIONS: ISBCS performed under general anaesthesia achieves target refraction in 83  % of eyes after consideration of complications, ocular co-morbidities and systemic restrictions. In the majority of cases where @entity2 power calculation could be considered, the achieved refraction of the second surgical eye was within   1.0 D of intended refraction. This undermines the utility of @entity2 power adjustments in the second surgical eye.

title: Predictability of refraction following immediate sequential bilateral XXXX surgery (ISBCS) performed under general anaesthesia.

answer: @entity1


abstract: The purpose of the study was to examine first-admitted @entity0 with @entity2 regarding social background, course and outcome. The study was handicapped by the lack of data of social variables as regards population in the catchment area, so comparisons were made with the population in the County and in the Nation. The index population comprised 88 @entity0 . Social variables such as civil state and cohabitation are presented. At admission one-third had been employed continuously during the past year, while one-fourth had had no useful work at all. Significantly more @entity0 were recruited from the lowest social group. Significantly more @entity0 had inadequate social support, and two-thirds met friends less than once a week on an average. Only one-fourth of the @entity0 seemed socially well adjusted and economically self-supporting. At follow-up 2 years later the distribution of the @entity0 as regards useful work, social support, social contacts and social adjustment has significantly changed with more @entity0 now with less useful work and social support, fewer social contacts and @entity3 . The difficulty of interpretation of the findings is stressed but it is concluded that the present @entity1 treatment including social intervention is insufficient to prevent this social downlift mobility during a 2-year observation period as regards @entity0 with @entity2 . Further study will search for social predictors of course and outcome.

title: Social course and outcome of XXXX .

answer: @entity2


abstract: One hundred and six @entity0 with @entity3 were treated with radical nephrectomy at our Department between 1970 to December, 1985. A retrospective analysis was performed with TNM staging system of The General Rule for Clinical and Pathological Studies on @entity3 , which was established by the Japanese Urological Association in 1983. The 5-year survival rate according to pathological @entity2 was 100% for 2 @entity0 in @entity5 , 67.5% for 58 @entity0 in pT2, 49.5% for 42 @entity0 in @entity4 , 0% for 4 @entity0 in pT4. Two @entity0 in stage of @entity5 had no venous involvement, lymph node @entity1 , or distant @entity1 . Twenty two @entity0 had positive venous involvement (21%), 4 (7%) in stage of pT2, 16 (38%) in @entity4 , 2 (50%) in pT4. Twelve @entity0 had positive lymph nodes (11%), 0 (0%) in stage of pT2, 10 (24%) in @entity4 , 2 (50%) in pT4. Twenty five @entity0 , (24%) had distant @entity1 at the time of nephrectomy, 8 (14%) in stage of pT2, 15 (38%) in @entity4 , 2 (50%) in pT4. The 5-year survival of 22 @entity0 with venous involvement, 12 @entity0 with lymph nodes @entity1 , 25 @entity0 with distant @entity1 were 47%, 30%, 39% respectively. No significant difference of 5-year survival between 69% of 48 @entity0 in T1 _ 2VoNoMo (Robson-I) and 76% of 12 @entity0 in T3VoNoMo (Robson-II) were considered to need the establishment of new classification for early stage of @entity3 . TNM staging system was thought to be better than Robson's Classification for analyzing the unique biological potential of @entity3 .

title: [Results of radical nephrectomy for XXXX . Report 1. Analysis according to the TNM staging system of the general rule for clinical and pathological studies on @entity3 ].

answer: @entity3


abstract: One hundred and six @entity0 with @entity3 were treated with radical nephrectomy at our Department between 1970 to December, 1985. A retrospective analysis was performed with TNM staging system of The General Rule for Clinical and Pathological Studies on @entity3 , which was established by the Japanese Urological Association in 1983. The 5-year survival rate according to pathological @entity2 was 100% for 2 @entity0 in @entity5 , 67.5% for 58 @entity0 in pT2, 49.5% for 42 @entity0 in @entity4 , 0% for 4 @entity0 in pT4. Two @entity0 in stage of @entity5 had no venous involvement, lymph node @entity1 , or distant @entity1 . Twenty two @entity0 had positive venous involvement (21%), 4 (7%) in stage of pT2, 16 (38%) in @entity4 , 2 (50%) in pT4. Twelve @entity0 had positive lymph nodes (11%), 0 (0%) in stage of pT2, 10 (24%) in @entity4 , 2 (50%) in pT4. Twenty five @entity0 , (24%) had distant @entity1 at the time of nephrectomy, 8 (14%) in stage of pT2, 15 (38%) in @entity4 , 2 (50%) in pT4. The 5-year survival of 22 @entity0 with venous involvement, 12 @entity0 with lymph nodes @entity1 , 25 @entity0 with distant @entity1 were 47%, 30%, 39% respectively. No significant difference of 5-year survival between 69% of 48 @entity0 in T1 _ 2VoNoMo (Robson-I) and 76% of 12 @entity0 in T3VoNoMo (Robson-II) were considered to need the establishment of new classification for early stage of @entity3 . TNM staging system was thought to be better than Robson's Classification for analyzing the unique biological potential of @entity3 .

title: [Results of radical nephrectomy for @entity3 . Report 1. Analysis according to the TNM staging system of the general rule for clinical and pathological studies on XXXX ].

answer: @entity3


abstract: Two cases of @entity7 are reported. Case I was a 71-year-old-male presenting with a mass in the left abdomen. On X-ray examination, a large extrarenal @entity0 was found in the left retroperitoneal space. The @entity0 appeared to invade the psoas muscle and the aorta. Exploratory laparotomy was carried out. The histological diagnosis of the @entity0 was @entity2 . He died of the disease. Case 2 was a 44-year-old-male who presented with a mass in the left abdomen. On X-ray examination, a large @entity0 was found in the left retroperitoneal space, and left kidney and the descending colon were markedly displaced by the @entity0 . Excisional surgery was carried out. The @entity0 was almost completely removed. The histological diagnosis was @entity2 . A combination chemotherapy ( @entity6 , @entity5 , @entity4 ) was started. but soon switched to radiation therapy because of @entity3 . Four months following the operation, there is no evidence of @entity1 . One hundred sixty three cases of @entity7 reported in Japan are reviewed.

title: [ XXXX : a report of 2 cases and review of 163 cases in Japan].

answer: @entity7


abstract: A bioassay for possible carcinogenicity of technical-grade @entity6 was conducted using Osborne-Mendel @entity3 and B6C3F1 @entity2 . @entity6 in @entity5 oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. The chemical was administered 5 days a week, cyclically for 44 of 78 weeks in @entity3 and continuously for 78 weeks in @entity2 , followed by an observation period of 33 or 34 weeks for @entity3 and 12 or 13 weeks for @entity2 . The high and low time-weighted average dosages of @entity6 were, respectively, 423 and 212 mg/kg/day for male and female @entity3 and 1179 and 590 mg/kg/day for male and female @entity2 . For each species, 20 animals of each sex were placed on test as vehicle controls. These animals were gavaged with pure @entity5 oil at the same rate as the high dose group of the same sex. Twenty animals of each sex were placed on test as untreated controls for each species. These animals were not intubated. A statistically significant association between increased dosage and accelerated mortality was observed in male and female @entity3 but not in @entity2 of either sex. @entity1 was observed in all groups of treated animals. Statistical evaluation of the incidences of @entity4 revealed a significant positive association between @entity6 administration and @entity0 incidence in both male and female @entity2 . No statistical significance was attributed to the incidence of any @entity0 in @entity3 of either sex. No evidence was provided for the carcinogenicity of the compound in Osborne-Mendel @entity3 . It is concluded that under the conditions of this bioassay, @entity6 was carcinogenic in B6C3F1 @entity2 , inducing @entity4 in both sexes.

title: Bioassay of XXXX for possible carcinogenicity.

answer: @entity6


abstract: BACKGROUND: Adults with @entity1 seem to be more distressed than their healthy counterparts, which might render them even more susceptible to developing detrimental health outcomes. Previous research has confirmed the relationship between the perceived impact of stress on health and self-rated health. However, it remains unknown whether sense of coherence, a @entity0 's capacity to cope with stressors, moderates this relationship. AIM: This cross-sectional study aims to explore: the relationship between demographic and clinical characteristics, sense of coherence, and the perceived impact of stress on health; the relationship between the perceived impact of stress on health and self-rated health; and the moderating effect of sense of coherence in a sample of adults with @entity1 . METHODS: @entity0 were recruited from the database of congenital and structural cardiology of a university hospital. The analytic sample included 255 @entity0 (median age 35 years; 50% @entity0 ). Data were obtained using self-report questionnaires and through medical record view. Univariate analyses and multiple regression analysis were conducted. RESULTS: The perceived impact of stress on health was negatively associated with sense of coherence (P<0.01), but there was no significant association with demographic or clinical characteristics. The perceived impact of stress on health and self-rated health were negatively associated (P<0.001), but sense of coherence did not moderate this relationship. CONCLUSIONS: Our findings support the need for further research on the perceived impact of stress on health. Such insights can be valuable for developing interventions aimed at reducing the negative health consequences of stress in @entity0 with @entity1 .

title: Sense of coherence does not moderate the relationship between the perceived impact of stress on health and self-rated health in adults with XXXX .

answer: @entity1