abstract: Background and Objectives. Glycemic control is of paramount importance in the intensive care unit. Presently, several BG control algorithms have been developed for clinical trials, but they are mostly based on experts' opinion and consensus. There are no validated models predicting how @entity3 levels will change after initiating of @entity6 infusion in critically ill @entity0 . The study aimed to develop an equation for initial @entity6 dose setting. Methods. A large critical care database was employed for the study. Linear regression model fitting was employed. Retested blood @entity3 was used as the independent variable. @entity6 rate was forced into the model. Multivariable fractional polynomials and interaction terms were used to explore the complex relationships among covariates. The overall fit of the model was examined by using residuals and adjusted R-squared values. Regression diagnostics were used to explore the influence of outliers on the model. Main Results. A total of 6,487 ICU admissions requiring @entity6 pump therapy were identified. The dataset was randomly split into two subsets at 7 to 3 ratio. The initial model comprised fractional polynomials and interactions terms. However, this model was not stable by excluding several outliers. I fitted a simple linear model without interaction. The selected prediction model (Predicting @entity3 Levels in ICU, PIGnOLI) included variables of initial blood @entity3 , @entity6 rate, PO volume, total parental nutrition, body mass index (BMI), @entity5 , @entity4 , @entity1 , @entity2 , time interval of BS recheck, dextrose rate. @entity6 rate was significantly associated with blood @entity3 reduction (coefficient: -0.52, 95% CI [-1.03, -0.01]). The parsimonious model was well validated with the validation subset, with an adjusted R-squared value of 0.8259. Conclusion. The study developed the PIGnOLI model for the initial @entity6 dose setting. Furthermore, experimental study is mandatory to examine whether adjustment of the @entity6 infusion rate based on PIGnOLI will benefit @entity0 ' outcomes.

title: A mathematical model for predicting XXXX levels in critically-ill @entity0 : the PIGnOLI model.

answer: @entity3


abstract: Background and Objectives. Glycemic control is of paramount importance in the intensive care unit. Presently, several BG control algorithms have been developed for clinical trials, but they are mostly based on experts' opinion and consensus. There are no validated models predicting how @entity3 levels will change after initiating of @entity6 infusion in critically ill @entity0 . The study aimed to develop an equation for initial @entity6 dose setting. Methods. A large critical care database was employed for the study. Linear regression model fitting was employed. Retested blood @entity3 was used as the independent variable. @entity6 rate was forced into the model. Multivariable fractional polynomials and interaction terms were used to explore the complex relationships among covariates. The overall fit of the model was examined by using residuals and adjusted R-squared values. Regression diagnostics were used to explore the influence of outliers on the model. Main Results. A total of 6,487 ICU admissions requiring @entity6 pump therapy were identified. The dataset was randomly split into two subsets at 7 to 3 ratio. The initial model comprised fractional polynomials and interactions terms. However, this model was not stable by excluding several outliers. I fitted a simple linear model without interaction. The selected prediction model (Predicting @entity3 Levels in ICU, PIGnOLI) included variables of initial blood @entity3 , @entity6 rate, PO volume, total parental nutrition, body mass index (BMI), @entity5 , @entity4 , @entity1 , @entity2 , time interval of BS recheck, dextrose rate. @entity6 rate was significantly associated with blood @entity3 reduction (coefficient: -0.52, 95% CI [-1.03, -0.01]). The parsimonious model was well validated with the validation subset, with an adjusted R-squared value of 0.8259. Conclusion. The study developed the PIGnOLI model for the initial @entity6 dose setting. Furthermore, experimental study is mandatory to examine whether adjustment of the @entity6 infusion rate based on PIGnOLI will benefit @entity0 ' outcomes.

title: A mathematical model for predicting @entity3 levels in critically-ill XXXX : the PIGnOLI model.

answer: @entity0


abstract: Between December 1966 and June 1982, 269 transplantations of vascularized pancreas (whole or segmental) were undertaken in 254 @entity1 @entity0 throughout the world. Most of the transplantations were performed in @entity0 with @entity7 who also received kidney grafts; a few @entity0 received pancreatic grafts only. About 25% of the pancreatic grafts are still functioning after periods of various lengths, the longest being five years. To the problem of how to handle the exocrine secretion there are two main approaches: 1) occlusion of the duct with a synthetic polymer and 2) pancreatico-enterostomy. A disadvantage of the former procedure is late @entity2 and @entity4 of the endocrine tissue. With the latter method duct leakage and @entity5 development cannot be completely prevented. In either case, @entity8 cause graft failure in about 20% of the operations. The risk of rejection of the graft seems not to differ significantly from that concerning other allogeneic organs, including the kidney and heart. Most of the @entity0 with a functioning pancreatic graft are normoglycemic: they have a normal or near-normal oral or intravenous @entity6 tolerance and an early insulin response to intravenous @entity6 tolerance and an early insulin response to intravenous @entity6 challenge. Whether the improvement of the motor and sensory nerve conduction velocities observed in some @entity0 whose graft has functioned for a long time is due to the reversal of @entity3 cannot yet be determined. At present, pancreas transplantation at Huddinge Hospital is performed only in conjunction with renal transplantation in @entity0 with end-stage @entity9 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX : present status.

answer: @entity1


abstract: BACKGROUND: The applicability of the Visual Analogue Scale (VAS) has been questioned in the assessment of @entity2 in the elderly. We compared VAS with three other @entity2 scales, Verbal Rating Scale (VRS), @entity4 ( @entity4 ) and @entity4 ( @entity4 ), in @entity3 @entity0 . METHODS: VAS, VRS, @entity4 and @entity4 were compared in 140 analysable @entity0 undergoing surgery, 70 with @entity3 and 70 with other lower limb @entity1 . @entity2 scores were recorded once a day, repeated after 10 min, for 4 subsequent days starting pre-operatively. The primary endpoint was the rate of @entity2 measurements in @entity3 @entity0 and 90% was chosen as a sufficient level for an applicable @entity2 scale. RESULTS: Age was different between the groups ( @entity3 78    11, other @entity1 49    11 years, P<0.0001). In @entity3 @entity0 , 67-83% of @entity2 measurements were successful with VAS, 82-100% with VRS, 83-96% with @entity4 and 79-91% with @entity4 . The success rate with VAS was significantly <90% on 2 days (P<0.0001) and with @entity4 on 1 day (P=0.04). All the other success rates with the four scales in both groups were above or not different from 90%. CONCLUSION: VRS and @entity4 were the most applicable scales, unlike VAS, which appeared to be an unreliable @entity2 scale in perioperative @entity3 @entity0 . In @entity0 with other lower limb @entity1 , all four scales provided excellent applicability. Our results are in accordance with the accumulating evidence suggesting that VAS is not an ideal tool for @entity2 measurement in the elderly.

title: Comparison of four @entity2 scales in XXXX with @entity3 or other lower limb @entity1 .

answer: @entity0


abstract: BACKGROUND: The applicability of the Visual Analogue Scale (VAS) has been questioned in the assessment of @entity2 in the elderly. We compared VAS with three other @entity2 scales, Verbal Rating Scale (VRS), @entity4 ( @entity4 ) and @entity4 ( @entity4 ), in @entity3 @entity0 . METHODS: VAS, VRS, @entity4 and @entity4 were compared in 140 analysable @entity0 undergoing surgery, 70 with @entity3 and 70 with other lower limb @entity1 . @entity2 scores were recorded once a day, repeated after 10 min, for 4 subsequent days starting pre-operatively. The primary endpoint was the rate of @entity2 measurements in @entity3 @entity0 and 90% was chosen as a sufficient level for an applicable @entity2 scale. RESULTS: Age was different between the groups ( @entity3 78    11, other @entity1 49    11 years, P<0.0001). In @entity3 @entity0 , 67-83% of @entity2 measurements were successful with VAS, 82-100% with VRS, 83-96% with @entity4 and 79-91% with @entity4 . The success rate with VAS was significantly <90% on 2 days (P<0.0001) and with @entity4 on 1 day (P=0.04). All the other success rates with the four scales in both groups were above or not different from 90%. CONCLUSION: VRS and @entity4 were the most applicable scales, unlike VAS, which appeared to be an unreliable @entity2 scale in perioperative @entity3 @entity0 . In @entity0 with other lower limb @entity1 , all four scales provided excellent applicability. Our results are in accordance with the accumulating evidence suggesting that VAS is not an ideal tool for @entity2 measurement in the elderly.

title: Comparison of four @entity2 scales in @entity0 with @entity3 or other lower limb XXXX .

answer: @entity1


abstract: BACKGROUND: The applicability of the Visual Analogue Scale (VAS) has been questioned in the assessment of @entity2 in the elderly. We compared VAS with three other @entity2 scales, Verbal Rating Scale (VRS), @entity4 ( @entity4 ) and @entity4 ( @entity4 ), in @entity3 @entity0 . METHODS: VAS, VRS, @entity4 and @entity4 were compared in 140 analysable @entity0 undergoing surgery, 70 with @entity3 and 70 with other lower limb @entity1 . @entity2 scores were recorded once a day, repeated after 10 min, for 4 subsequent days starting pre-operatively. The primary endpoint was the rate of @entity2 measurements in @entity3 @entity0 and 90% was chosen as a sufficient level for an applicable @entity2 scale. RESULTS: Age was different between the groups ( @entity3 78    11, other @entity1 49    11 years, P<0.0001). In @entity3 @entity0 , 67-83% of @entity2 measurements were successful with VAS, 82-100% with VRS, 83-96% with @entity4 and 79-91% with @entity4 . The success rate with VAS was significantly <90% on 2 days (P<0.0001) and with @entity4 on 1 day (P=0.04). All the other success rates with the four scales in both groups were above or not different from 90%. CONCLUSION: VRS and @entity4 were the most applicable scales, unlike VAS, which appeared to be an unreliable @entity2 scale in perioperative @entity3 @entity0 . In @entity0 with other lower limb @entity1 , all four scales provided excellent applicability. Our results are in accordance with the accumulating evidence suggesting that VAS is not an ideal tool for @entity2 measurement in the elderly.

title: Comparison of four XXXX scales in @entity0 with @entity3 or other lower limb @entity1 .

answer: @entity2


abstract: BACKGROUND: The applicability of the Visual Analogue Scale (VAS) has been questioned in the assessment of @entity2 in the elderly. We compared VAS with three other @entity2 scales, Verbal Rating Scale (VRS), @entity4 ( @entity4 ) and @entity4 ( @entity4 ), in @entity3 @entity0 . METHODS: VAS, VRS, @entity4 and @entity4 were compared in 140 analysable @entity0 undergoing surgery, 70 with @entity3 and 70 with other lower limb @entity1 . @entity2 scores were recorded once a day, repeated after 10 min, for 4 subsequent days starting pre-operatively. The primary endpoint was the rate of @entity2 measurements in @entity3 @entity0 and 90% was chosen as a sufficient level for an applicable @entity2 scale. RESULTS: Age was different between the groups ( @entity3 78    11, other @entity1 49    11 years, P<0.0001). In @entity3 @entity0 , 67-83% of @entity2 measurements were successful with VAS, 82-100% with VRS, 83-96% with @entity4 and 79-91% with @entity4 . The success rate with VAS was significantly <90% on 2 days (P<0.0001) and with @entity4 on 1 day (P=0.04). All the other success rates with the four scales in both groups were above or not different from 90%. CONCLUSION: VRS and @entity4 were the most applicable scales, unlike VAS, which appeared to be an unreliable @entity2 scale in perioperative @entity3 @entity0 . In @entity0 with other lower limb @entity1 , all four scales provided excellent applicability. Our results are in accordance with the accumulating evidence suggesting that VAS is not an ideal tool for @entity2 measurement in the elderly.

title: Comparison of four @entity2 scales in @entity0 with XXXX or other lower limb @entity1 .

answer: @entity3


abstract: UNASSIGNED: Control and elimination of @entity2 still represents a major public health challenge. Emerging parasite resistance to current therapies urges development of antimalarials with novel mechanism of action. Phospholipid biosynthesis of the @entity6 parasite has been validated as promising candidate antimalarial target. The most prevalent de novo pathway for synthesis of @entity4 is the Kennedy pathway. Its regulatory and often also rate limiting step is catalyzed by @entity0 : @entity5 cytidylyltransferase (CCT). The CHO-MT58 cell line expresses a mutant variant of CCT, and displays a thermo-sensitive phenotype. At non-permissive temperature (40  C), the endogenous CCT activity decreases dramatically, blocking membrane synthesis and ultimately leading to apoptosis. In the present study we investigated the impact of the analogous mutation in a catalytic domain construct of @entity6 CCT in order to explore the underlying molecular mechanism that explains this phenotype. We used temperature dependent enzyme activity measurements and modeling to investigate the functionality of the mutant enzyme. Furthermore, MS measurements were performed to determine the oligomerization state of the protein, and @entity3 simulations to assess the inter-subunit interactions in the dimer. Our results demonstrate that the @entity7 mutation does not directly influence enzyme catalytic activity. Instead, it provokes @entity1 by destabilizing the CCT dimer. This can possibly explain the significance of the PfCCT pseudoheterodimer organization in ensuring proper enzymatic function. This also provide an explanation for the observed thermo-sensitive phenotype of CHO-MT58 cell line.

title: Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant @entity0 : XXXX Cytidylyltransferase.

answer: @entity5


abstract: UNASSIGNED: Control and elimination of @entity2 still represents a major public health challenge. Emerging parasite resistance to current therapies urges development of antimalarials with novel mechanism of action. Phospholipid biosynthesis of the @entity6 parasite has been validated as promising candidate antimalarial target. The most prevalent de novo pathway for synthesis of @entity4 is the Kennedy pathway. Its regulatory and often also rate limiting step is catalyzed by @entity0 : @entity5 cytidylyltransferase (CCT). The CHO-MT58 cell line expresses a mutant variant of CCT, and displays a thermo-sensitive phenotype. At non-permissive temperature (40  C), the endogenous CCT activity decreases dramatically, blocking membrane synthesis and ultimately leading to apoptosis. In the present study we investigated the impact of the analogous mutation in a catalytic domain construct of @entity6 CCT in order to explore the underlying molecular mechanism that explains this phenotype. We used temperature dependent enzyme activity measurements and modeling to investigate the functionality of the mutant enzyme. Furthermore, MS measurements were performed to determine the oligomerization state of the protein, and @entity3 simulations to assess the inter-subunit interactions in the dimer. Our results demonstrate that the @entity7 mutation does not directly influence enzyme catalytic activity. Instead, it provokes @entity1 by destabilizing the CCT dimer. This can possibly explain the significance of the PfCCT pseudoheterodimer organization in ensuring proper enzymatic function. This also provide an explanation for the observed thermo-sensitive phenotype of CHO-MT58 cell line.

title: Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant XXXX : @entity5 Cytidylyltransferase.

answer: @entity0


abstract: UNASSIGNED: The morbidity and mortality caused by @entity3 ( @entity3 ) are still significant. Conservative treatment of @entity3 is often ineffective. Treatment modalities using stem cells directly into the @entity3 or systematically have been introduced recently. Ischemic preconditioning (IPC) has been proved to be a cheap, simple, and safe method which can augment stem cells number in the peripheral blood circulation. This study's purpose was to test whether IPC can improve @entity3 healing. Forty @entity1 @entity0 were enrolled and divided into study and control groups. All @entity0 received their regular treatment. The study group @entity0 received in addition brief, transient cycles of IPC while the control group @entity0 received a sham procedure only. The procedure was repeated every 2 weeks to complete a follow-up period of 6 weeks. The @entity2 were photographed to measure wound area, and the degree of granulation tissue was assessed. No serious adverse events were noted. Twenty-two @entity0 from the study group and 12 from the control group completed the entire follow-up. The ratio of @entity0 who reached complete healing of their ulcer was 9/22 (41%) in the study group compared with 0/12 (0%) in the control group, p   =   0.01. Furthermore, the mean remaining ulcer area at the end of the follow-up was significantly smaller in the study group, 25        6% of the initial area vs. 61        10% in the control group, p   =   0.007. The degree of granulation increased after one cycle of treatment in 8/24 (33%) study @entity0 compared to 3/16 (19%) in the control group, p   =   0.47. Remote, repeated IPC significantly improves the healing of @entity3 . This simple, safe, inexpensive treatment method should be considered to be routinely applied to @entity1 @entity0 with @entity3 in addition to other regular treatment modalities.

title: Intermittent cycles of remote ischemic preconditioning augment XXXX healing.

answer: @entity3


abstract: PURPOSE: The aim of the present study was to review the published data regarding the management of polymorphous low-grade @entity3 ( @entity6 ) and present our experience in the treatment of @entity0 diagnosed with @entity6 . MATERIALS AND METHODS: We performed a review of the published data of the treatment possibilities for @entity6 , and report on a case series of 4 @entity0 diagnosed with palatal @entity6 . RESULTS: The mean age at diagnosis was 61.75 years. All cases were localized on the hard palate. The male/female ratio was 1:3. One @entity0 had an ulcerative painful lump. In correlation with the published data, most of our @entity0 presented initially with a diagnosis that was not conclusive for the presence of @entity6 . The most common initial diagnostic findings were @entity4 and @entity5 . The treatment of choice was surgical excision of the @entity2 with safe margins of 1.5 cm. One @entity0 had a positive cervical lymph node @entity1 and underwent an elective neck dissection followed by radiotherapy. Local recurrence was diagnosed in 1 @entity0 6 years after the surgical management. Most cases were reconstructed using an obturator, except for 1 @entity0 who underwent reconstruction using the temporalis myofascial flap. CONCLUSIONS: @entity6 is a slow-growing, distinct, uncommon @entity2 of the minor salivary glands. Because it is characterized by a diverse morphologic pattern that resembles @entity4 or @entity5 , the initial diagnosis is usually inconclusive. Until a final diagnosis has been made, we believe that the reconstruction possibilities should be mainly obturators to allow a good visualization of the surgical site. The use of microvascular free flaps or rotational flaps should be reserved to @entity0 with clearer pathologic diagnosis.

title: Polymorphous low grade XXXX : case series and review of surgical management.

answer: @entity3


abstract: BACKGROUND: The Danish Cancer Registry (DCR) is the oldest nationwide population-based @entity1 registry in the Nordic countries. At the time of the study the DCR recorded date of diagnosis, @entity1 stage and initial treatment. The validity of the clinical information reported to the DCR has never been analyzed. MATERIAL AND METHODS: @entity0 diagnosed with @entity2 from 1 May to 31 December 1997 and living in eight Danish counties were identified through the DCR. Clinical data was retrieved from hospital records where date of diagnosis, stage at diagnosis and treatment received were registered. RESULTS: The mean age at diagnosis was 74.6 years (s.d. 8.6 years). Diagnosis was verified histologically for 87% of cases. Overall 95% of the @entity0 had a difference less than three months between the reported date of diagnosis and the date found in hospital records. Correction of dates of diagnosis had no impact on survival. Hospital records identified 86 @entity0 with T1-2 disease without distant metastases (M0), but only 56 of these @entity0 (65%) were reported to the DCR as having localized disease. According to hospital records a total of 242 @entity0 were confirmed having distant metastases (M1) at diagnosis but only 139 of these cases (57%) were reported to the DCR as such. Considerable "over reporting" of curative treatment was observed. CONCLUSION: The DCR has been shown to be reliable in terms of new cases being reported. For the majority of cases there were insignificant differences concerning the date of diagnosis. However, the DCR information on stage and treatment was found to be inaccurate. Since 2004 the DCR registration process, including staging according to the TNM classification, has been carried out electronically from several registers. Future comparison between cohorts of different time intervals or international comparison should be interpreted with caution when clinical information is included.

title: Quality assessment of XXXX reports to the Danish Cancer Registry.

answer: @entity2


abstract: BACKGROUND: The supraclavicular ultrasound (US)-guided cannulation of the brachiocephalic vein ( @entity1 ) is one option of central venous line placement in @entity0 . AIM: The aim of this prospective study was to evaluate whether there was an association between the optimum ultrasonographic view as obtained of the entire longitudinal extension of the right @entity1 and the ease of supraclavicular cannulation when using a strict in-plane technique via a linear US probe in small @entity0 . METHODS: The US probe was placed in the right supraclavicular region. If the optimum obtainable sonographic view presented the entire longitudinal extension of the right @entity1 demonstrating clearly its path caudally alongside the pleura, it was graded as I. If, however, only a circular view, i.e., the initial part of the right @entity1 was obtainable via US, it was graded as II. The right @entity1 was cannulated by advancing a 22-gauge i.v. cannula from lateral to medial strictly under the long axis of the US probe under direct US vision into the vein. RESULTS: Seventy-nine @entity0 weighing between 0.8 and 4.5  kg (Median: 3.4      0.09) were included. In 50 (63.3%) @entity0 , the sonographic view was graded as I and in 29 (36.7%) as II. The proportion of @entity0 successfully cannulated on the first attempt was significantly smaller in @entity0 graded as II, i.e., circular, sonographic view of the right @entity1 than in @entity0 graded as I, i.e., sonographic view of the entire longitudinal extension of the right @entity1 (41% vs 90%; chi-square analysis: P  <  0.01). CONCLUSION: The sonographic view obtainable of the entire longitudinal extension of the right @entity1 resulted in significantly fewer required cannulation attempts.

title: Ultrasound-guided supraclavicular cannulation of the right brachiocephalic vein in small XXXX : a consecutive, prospective case series.

answer: @entity0


abstract: UNASSIGNED: The goal of this study was to propose a new functional magnetic resonance imaging (fMRI) paradigm using a language-free adaptation of a 2-back working memory task to avoid cultural and educational bias. We additionally provide an index of the validity of the proposed paradigm and test whether the experimental task discriminates the behavioural performances of healthy @entity0 from those of individuals with working @entity4 . Ten healthy @entity0 and nine @entity0 presenting working @entity4 due to @entity3 ( @entity3 ) performed the developed task. To inspect whether the paradigm activates brain areas typically involved in @entity2 ( @entity2 ), brain activation of the healthy @entity0 was assessed with fMRIs. To examine the task's capacity to discriminate behavioural data, performances of the healthy @entity0 in the task were compared with those of @entity3 @entity0 . Data were analysed with GLM-based random effects procedures and t-tests. We found an increase of the BOLD signal in the specialized areas of @entity2 . Concerning behavioural performances, healthy @entity0 showed the predicted pattern of more hits, less omissions and a tendency for fewer @entity5 , more self-corrected responses, and faster reaction times, when compared with subjects presenting @entity1 . The results suggest that this task activates brain areas involved in @entity2 and discriminates behavioural performances of clinical and non-clinical groups. It can thus be used as a research methodology for behavioural and neuroimaging studies of @entity2 in block-design paradigms.

title: Study of behavioural and neural bases of XXXX with an fMRI paradigm based on an n-back task.

answer: @entity4


abstract: OBJECTIVE: The treatment of @entity1 addiction in Brazil has expanded in recent years; however, we must increase knowledge about the characteristics of individuals who adhere to cessation programs in order to adjust treatments to specific characteristics of the target population that favor success. The aim of this study was to describe the characteristics of smokers who present to Brazilian public health units seeking help to quit smoking based on the experience of a primary health care unit that covers a poor community in the city of Rio de Janeiro. METHODS: Data were collected at a Teaching Health Center from January 03 2012 to January 03 2014. RESULTS: Mean @entity0 age was 49.32  11.82 years, and 71% were @entity0 . About half of the @entity0 successfully quit smoking (n=125, 51%). Higher levels of @entity3 @entity2 were associated with lower levels of smoking cessation. There was a notable decrease in the probability of remaining smoking throughout the first month of treatment. After 3 weeks of treatment, only 19% had not quit smoking. The probability of quitting smoking decreases by 2% for every additional year of age. CONCLUSION: There is a need to revise and expand current strategies to make them more effective in preventing smoking since childhood.

title: Profile of Brazilian smokers in the National Program for XXXX Control.

answer: @entity1


abstract: INTRODUCTION: Postoperative @entity6 are well-recognised complications of both surgery and anaesthesia and a leading cause of litigation claims. We present a rare cause of compressive sensory and motor neuropraxia of the median, ulnar and radial nerves of the right hand resulting from a wristwatch that was worn on the first postoperative night following minor surgery. Mechanisms of this compressive @entity2 are discussed, with specific recommendations made regarding the wearing of wristwatches, jewellery and constrictive clothing in the immediate postoperative period. CASE PRESENTATION: A 12-year-old white @entity0 presented with a complete glove and stocking sensory and motor @entity2 involving his right hand from a wristwatch that was worn on the first postoperative night following uneventful surgery for a minor procedure. Over the following 12 hours the @entity1 and @entity7 resolved with complete return of motor function. After 18 hours, the @entity3 completely resolved. CONCLUSIONS: @entity4 is often preventable. Paediatric @entity0 , especially if thin, may be particularly susceptible to a @entity8 from constrictive clothing or jewellery, in particular circumferential varieties such as wristwatches. These items should not be worn in the immediate postoperative period as pressure on peripheral nerves can result in severe and @entity5 . Education should be given to all medical staff, carers or parents of @entity0 undergoing surgery on the avoidance of wearing wristwatches, jewellery or constrictive clothing in the immediate postoperative period. Early medical evaluation of any @entity4 is of paramount importance.

title: Postoperative wristwatch-induced compressive XXXX of the hand: a case report.

answer: @entity2


abstract: OBJECTIVES: To examine the interaction of types and numbers of antecedent nonbladder syndromes (NBSs) to seek clues to the pathogenesis of @entity5 / @entity6 ( @entity7 /PBS). Numerous case series have shown @entity7 /PBS to be associated with several syndromes that do not include @entity3 . In a previously reported case-control study, we confirmed these findings and found that such nonbladder syndromes often preceded the onset of @entity7 /PBS. METHODS: Incident female @entity7 /PBS cases (n = 312) and matched controls were compared for 11 antecedent NBSs. The odds ratios (ORs) for @entity7 /PBS according to the number of antecedent NBSs per @entity0 were calculated. From this model, each @entity9 was serially removed, and the calculations for the ORs were repeated using the remaining 10 NBSs. We assessed the types of NBSs included in each subgroup formed by the number of NBSs. RESULTS: The ORs for @entity7 /PBS increased with the increasing number of antecedent NBSs. The types of NBSs were interchangeable in calculating these ORs. The distribution of the types of NBSs was skewed, with @entity2 overrepresented in those with few NBSs, and the classic functional somatic syndromes of @entity1 , @entity8 , and @entity4 overrepresented in those with many NBSs. CONCLUSIONS: Two main hypotheses were generated. One was that the incidence of a @entity9 initiated a process that contributed to the emergence of other NBSs and @entity7 /PBS. The second was that each @entity9 and @entity7 /PBS was a manifestation of a common, shared pathogenesis. It is likely that a well-designed prospective study will be necessary to distinguish between these 2 hypotheses.

title: Numbers and types of nonbladder syndromes as risk factors for XXXX / @entity6 .

answer: @entity5


abstract: OBJECTIVES: To examine the interaction of types and numbers of antecedent nonbladder syndromes (NBSs) to seek clues to the pathogenesis of @entity5 / @entity6 ( @entity7 /PBS). Numerous case series have shown @entity7 /PBS to be associated with several syndromes that do not include @entity3 . In a previously reported case-control study, we confirmed these findings and found that such nonbladder syndromes often preceded the onset of @entity7 /PBS. METHODS: Incident female @entity7 /PBS cases (n = 312) and matched controls were compared for 11 antecedent NBSs. The odds ratios (ORs) for @entity7 /PBS according to the number of antecedent NBSs per @entity0 were calculated. From this model, each @entity9 was serially removed, and the calculations for the ORs were repeated using the remaining 10 NBSs. We assessed the types of NBSs included in each subgroup formed by the number of NBSs. RESULTS: The ORs for @entity7 /PBS increased with the increasing number of antecedent NBSs. The types of NBSs were interchangeable in calculating these ORs. The distribution of the types of NBSs was skewed, with @entity2 overrepresented in those with few NBSs, and the classic functional somatic syndromes of @entity1 , @entity8 , and @entity4 overrepresented in those with many NBSs. CONCLUSIONS: Two main hypotheses were generated. One was that the incidence of a @entity9 initiated a process that contributed to the emergence of other NBSs and @entity7 /PBS. The second was that each @entity9 and @entity7 /PBS was a manifestation of a common, shared pathogenesis. It is likely that a well-designed prospective study will be necessary to distinguish between these 2 hypotheses.

title: Numbers and types of nonbladder syndromes as risk factors for @entity5 / XXXX .

answer: @entity6


abstract: PURPOSE: This study aimed to determine gender and race variations in regards to the influence of religious involvement (RI) as a moderator of the effects of early traumatic stress (ETS) on health-related quality of life among adult survivors of @entity0 abuse. DESIGN: A cross-sectional predictive design was used to study Seventh-day Adventist adults in North America (N = 10,283). METHODS: A secondary analysis of data collected via questionnaires was done using multiple regression. RESULTS: Data revealed that @entity0 had a significantly higher prevalence of any or all ETS subtypes, except for physical abuse prevalence, which was the same for both genders. Blacks reported a significantly higher prevalence of at least one ETS subtype than did Whites, except for neglect, where Whites had a higher prevalence. Exposure to at least one ETS subtype was associated with worse negative effect on mental health (B = -2.08, p < .0001 vs. B = -1.54, p < .0001) and physical health (B = -2.01, p < .0001 vs. B = -1.11, p < .0001) for @entity0 compared to @entity0 . Among those exposed to all ETS subtypes (n = 447), Whites had significant worse physical health, with White @entity0 having almost two times the negative effect on physical health (B = -4.50, p < .0001) than White @entity0 (B = -2.87, p < .05). As for RI moderation, based on tests of three-way interactions of race-RI-ETS, there were no associated differences. However, tests of three-way interactions of gender-RI-ETS showed a significant buffering effect. Among those with high levels of negative religious coping (RC), @entity0 exposed to ETS had significantly worse physical health (B = -1.28) than @entity0 . CONCLUSIONS: Results give evidence of gender and racial differences on the magnitude of the ETS-health effect, as well as gender differences in ETS-health buffering by RC. CLINICAL RELEVANCE: Findings suggest gender and racial differences must be considered when devising holistic nursing interventions for improving health outcomes of early @entity1 survivors.

title: Gender and Race Variations in the Intersection of Religious Involvement, Early XXXX , and Adult Health.

answer: @entity1


abstract: BACKGROUND: @entity7 is an a4b2 partial nicotinic agonist approved for smoking cessation. There have been spontaneous postmarketing reports of neuropsychiatric adverse events (NPAEs) in smokers without a history of @entity2 quitting with @entity7 . METHODS: One hundred ten smokers without history of @entity2 (screened by Structured Clinical Interview for DSM-IV) were randomized to 12 weeks of @entity7 1 mg twice daily (n = 55) or placebo. Adverse events were solicited systematically. @entity4 , @entity3 , @entity2 , and @entity2 were measured at baseline and weekly using the Montgomery-  sberg Depression Rating Scale (MADRS), the Hamilton Anxiety Scale (HAM-A), and the Overt Aggression Scale-Modified ( @entity8 -M). The Profile of Mood States (POMS) was administered daily. Mixed-model analysis of repeated measures was conducted to compare mean changes in scores between groups across study periods. RESULTS: @entity0 ' mean baseline characteristics were 33 years of age, 22 cigarettes/day and Fagerstr  m Test for @entity6 @entity5 score > 7. Reported NPAEs were similar between groups. No suicidal events were reported. There were no significant differences between groups for the MADRS ( @entity1 vs. placebo = .03, 95% confidence interval [CI] -.68-.73; NS), HAM-A ( @entity1 [ @entity1 ] = .14, 95% CI -.62-.90; NS), @entity8 -M Aggression subscale ( @entity1 = .5, 95% CI -1.18-2.18; NS), @entity8 -M Irritability subscale ( @entity1 = .08, 95% CI -.17-.34; NS), and the POMS total scores ( @entity1 = .5, 95% CI -.52-1.53; NS). CONCLUSIONS: There were no significant differences between groups on measures of @entity4 , @entity3 , or @entity2 /hostility. Systematically solicited NPAEs were similar between the @entity7 and placebo groups.

title: A double-blind randomized placebo-controlled pilot study of neuropsychiatric adverse events in abstinent smokers treated with XXXX or placebo.

answer: @entity7


abstract: OBJECTIVE: To investigate acute @entity1 in the peritoneal cavity in adhesion formation. DESIGN: Prospective randomized, controlled trial. SETTING: University laboratory research center. ANIMAL(S): 9- to 10-week-old BALB/c female @entity0 . INTERVENTION(S): In a laparoscopic @entity0 model, acute @entity1 in the peritoneal cavity evaluated in @entity2 @entity3 enhanced @entity5 , by @entity2 @entity3 plus manipulation, and in the latter group plus @entity4 . MAIN OUTCOME MEASURE(S): Qualitative and quantitative adhesion scores and an acute @entity1 score (neoangiogenesis, diapedesis, and leukocyte accumulation). RESULT(S): Adhesions at the lesion site were enhanced by the @entity2 @entity3 , further enhanced by manipulation, and decreased by the administration of @entity4 . The acute @entity1 scores (total, neoangiogenesis, diapedesis, and leukocyte accumulation) strongly correlated with the total adhesion score. @entity1 scores were similar at both the surgical lesion and the parietal peritoneum. CONCLUSION(S): Acute @entity1 of the entire peritoneum cavity is an important mechanism involved in adhesion formation and enhances adhesion formation at the lesion site.

title: Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic XXXX model.

answer: @entity0


abstract: @entity3 is a rare but well-established complication of @entity2 with a prevalence of 0.73% in one large autopsy series. In this report, we review the findings on chest radiographs in eight @entity0 with this complication. Portal @entity2 in these @entity0 was evidenced by the presence of @entity7 . The causes of @entity2 were @entity6 in seven @entity0 and portal @entity1 in one @entity0 . @entity3 was established by right heart catheterization and pressure measurement. Qualitative assessment of the radiographs showed that four @entity0 had the classic findings of @entity3 including prominent central pulmonary arteries and @entity8 , three had @entity4 , and one had only @entity5 . Measurements of the width of the right descending pulmonary artery and the pulmonary lobar diameter/transverse thoracic diameter ratio were made in five of the @entity0 in whom postero-anterior radiographs were available. The results confirmed our qualitative analysis, although they did not establish the diagnosis in borderline cases. We also observed that pulmonary vascular redistribution to the upper lobes was present in four @entity0 , a finding that has been reported in @entity0 with other causes of @entity3 . We conclude that the possibility of @entity3 should be raised in @entity0 with @entity2 , even when only subtle chest radiographic findings are present to suggest that diagnosis.

title: XXXX complicating @entity2 : findings on chest radiographs.

answer: @entity3


abstract: @entity3 is a rare but well-established complication of @entity2 with a prevalence of 0.73% in one large autopsy series. In this report, we review the findings on chest radiographs in eight @entity0 with this complication. Portal @entity2 in these @entity0 was evidenced by the presence of @entity7 . The causes of @entity2 were @entity6 in seven @entity0 and portal @entity1 in one @entity0 . @entity3 was established by right heart catheterization and pressure measurement. Qualitative assessment of the radiographs showed that four @entity0 had the classic findings of @entity3 including prominent central pulmonary arteries and @entity8 , three had @entity4 , and one had only @entity5 . Measurements of the width of the right descending pulmonary artery and the pulmonary lobar diameter/transverse thoracic diameter ratio were made in five of the @entity0 in whom postero-anterior radiographs were available. The results confirmed our qualitative analysis, although they did not establish the diagnosis in borderline cases. We also observed that pulmonary vascular redistribution to the upper lobes was present in four @entity0 , a finding that has been reported in @entity0 with other causes of @entity3 . We conclude that the possibility of @entity3 should be raised in @entity0 with @entity2 , even when only subtle chest radiographic findings are present to suggest that diagnosis.

title: @entity3 complicating XXXX : findings on chest radiographs.

answer: @entity2


abstract: BACKGROUND: @entity3 ( @entity3 ) is the leading cause of death in @entity0 worldwide and a substantial proportion of childhood @entity3 is caused by viruses. A better understanding of the role of @entity4 in this condition is needed to improve clinical management and preventive measures. The aim of the study was therefore to assess the association between specific @entity6 viruses and childhood @entity3 . METHODS: A case-control study was conducted during 3   years in Stockholm, Sweden. Cases were @entity0 aged  <=5   years with radiological @entity3 . Healthy controls were consecutively enrolled at @entity0 health units during routine visits and matched to cases on age and calendar time. Nasopharyngeal aspirates were obtained and analysed by real-time PCR for 15 viruses. Multivariate conditional logistic regression was used to account for @entity2 with other viruses and baseline characteristics. RESULTS: A total of 121 cases, of which 93 cases met the WHO criteria for radiological @entity1 , and 240 controls were included in the study. Viruses were detected in 81% of the cases (n=98) and 56% of the controls (n=134). Influenza virus, metapneumovirus and @entity6 were detected in 60% of cases and were significantly associated with @entity3 with ORs >10. There was no association with @entity8 virus, @entity0 @entity5 and coronavirus and bocavirus were negatively associated with @entity3 . CONCLUSIONS: Our study indicates viral @entity3 is an underestimated disease and points out @entity7 as a new important target for the prevention of childhood @entity3 .

title: XXXX viruses associated with community-acquired @entity1 in @entity0 : matched case-control study.

answer: @entity6


abstract: BACKGROUND: @entity3 ( @entity3 ) is the leading cause of death in @entity0 worldwide and a substantial proportion of childhood @entity3 is caused by viruses. A better understanding of the role of @entity4 in this condition is needed to improve clinical management and preventive measures. The aim of the study was therefore to assess the association between specific @entity6 viruses and childhood @entity3 . METHODS: A case-control study was conducted during 3   years in Stockholm, Sweden. Cases were @entity0 aged  <=5   years with radiological @entity3 . Healthy controls were consecutively enrolled at @entity0 health units during routine visits and matched to cases on age and calendar time. Nasopharyngeal aspirates were obtained and analysed by real-time PCR for 15 viruses. Multivariate conditional logistic regression was used to account for @entity2 with other viruses and baseline characteristics. RESULTS: A total of 121 cases, of which 93 cases met the WHO criteria for radiological @entity1 , and 240 controls were included in the study. Viruses were detected in 81% of the cases (n=98) and 56% of the controls (n=134). Influenza virus, metapneumovirus and @entity6 were detected in 60% of cases and were significantly associated with @entity3 with ORs >10. There was no association with @entity8 virus, @entity0 @entity5 and coronavirus and bocavirus were negatively associated with @entity3 . CONCLUSIONS: Our study indicates viral @entity3 is an underestimated disease and points out @entity7 as a new important target for the prevention of childhood @entity3 .

title: @entity6 viruses associated with community-acquired XXXX in @entity0 : matched case-control study.

answer: @entity1


abstract: BACKGROUND: @entity3 ( @entity3 ) is the leading cause of death in @entity0 worldwide and a substantial proportion of childhood @entity3 is caused by viruses. A better understanding of the role of @entity4 in this condition is needed to improve clinical management and preventive measures. The aim of the study was therefore to assess the association between specific @entity6 viruses and childhood @entity3 . METHODS: A case-control study was conducted during 3   years in Stockholm, Sweden. Cases were @entity0 aged  <=5   years with radiological @entity3 . Healthy controls were consecutively enrolled at @entity0 health units during routine visits and matched to cases on age and calendar time. Nasopharyngeal aspirates were obtained and analysed by real-time PCR for 15 viruses. Multivariate conditional logistic regression was used to account for @entity2 with other viruses and baseline characteristics. RESULTS: A total of 121 cases, of which 93 cases met the WHO criteria for radiological @entity1 , and 240 controls were included in the study. Viruses were detected in 81% of the cases (n=98) and 56% of the controls (n=134). Influenza virus, metapneumovirus and @entity6 were detected in 60% of cases and were significantly associated with @entity3 with ORs >10. There was no association with @entity8 virus, @entity0 @entity5 and coronavirus and bocavirus were negatively associated with @entity3 . CONCLUSIONS: Our study indicates viral @entity3 is an underestimated disease and points out @entity7 as a new important target for the prevention of childhood @entity3 .

title: @entity6 viruses associated with community-acquired @entity1 in XXXX : matched case-control study.

answer: @entity0


abstract: PURPOSE: @entity1 ( @entity1 ) is frequent in @entity0 eligible for cardiac resynchronization therapy (CRT) and may be worsened by the use of contrast agents. We sought to determine the feasibility of CRT implantation without contrast injection in @entity0 with contraindication to @entity4 . METHODS: @entity0 eligible for CRT and presenting with @entity1 were prospectively included (non-contrast NC group). A contemporary control group (CG) of CRT @entity0 with contrast injection was used for comparison. An over-the-wire coronary sinus (CS) lead with an angled distal tip was selected for this "blind harpooning" technique. RESULTS: Seventeen @entity0 in the NC group were included (78        7  years). Serum @entity3 was 208        86   mol/L (glomerular filtration rate 33        15  mL/ @entity2 .73  m(2)). CG included 25 @entity0 (70        7  years, serum @entity3 85        21   mol/L). CRT implantation was successful in 16/17 @entity0 (94.1  %) without contrast injection. The mean procedure and fluoroscopy times were similar in the two groups: 146        29 in the NC group versus 153        25  min (p   =   0.57) and 25        12 in the NC group versus 23        16  min (p   =   0.7) respectively. The mean CS lead implantation time was 36        19 (NC group) versus 39        15  min (p   =   0.64). No major procedure-related complications were observed in both groups. CONCLUSION: CRT implantation is feasible in the majority of the cases (94.1  %) without contrast injection and without lengthening the procedure time in @entity0 with @entity1 .

title: Non-contrast cardiac resynchronization therapy implantation is feasible in case of XXXX .

answer: @entity1


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity0 with @entity4 2 @entity1 are not well-understood. The study objective was to evaluate effects of conjugated @entity8 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity3 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity8 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity2 @entity0 with @entity4 2 @entity1 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity6 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity5 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity8 in serum of @entity0 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity3 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity1 treatments to improve risk factors for @entity7 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity3 and blood lipids in @entity2 , post-menopausal @entity0 with XXXX 2 @entity1 : a randomized, double-masked, crossover study.

answer: @entity4


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity0 with @entity4 2 @entity1 are not well-understood. The study objective was to evaluate effects of conjugated @entity8 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity3 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity8 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity2 @entity0 with @entity4 2 @entity1 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity6 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity5 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity8 in serum of @entity0 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity3 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity1 treatments to improve risk factors for @entity7 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity3 and blood lipids in XXXX , post-menopausal @entity0 with @entity4 2 @entity1 : a randomized, double-masked, crossover study.

answer: @entity2


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity0 with @entity4 2 @entity1 are not well-understood. The study objective was to evaluate effects of conjugated @entity8 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity3 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity8 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity2 @entity0 with @entity4 2 @entity1 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity6 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity5 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity8 in serum of @entity0 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity3 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity1 treatments to improve risk factors for @entity7 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity3 and blood lipids in @entity2 , post-menopausal @entity0 with @entity4 2 XXXX : a randomized, double-masked, crossover study.

answer: @entity1


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity0 with @entity4 2 @entity1 are not well-understood. The study objective was to evaluate effects of conjugated @entity8 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity3 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity8 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity2 @entity0 with @entity4 2 @entity1 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity6 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity5 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity8 in serum of @entity0 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity3 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity1 treatments to improve risk factors for @entity7 .

title: Time-dependent effects of safflower oil to improve glycemia, XXXX and blood lipids in @entity2 , post-menopausal @entity0 with @entity4 2 @entity1 : a randomized, double-masked, crossover study.

answer: @entity3


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity0 with @entity4 2 @entity1 are not well-understood. The study objective was to evaluate effects of conjugated @entity8 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity3 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity8 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity2 @entity0 with @entity4 2 @entity1 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity6 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity5 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity8 in serum of @entity0 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity3 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity1 treatments to improve risk factors for @entity7 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity3 and blood lipids in @entity2 , post-menopausal XXXX with @entity4 2 @entity1 : a randomized, double-masked, crossover study.

answer: @entity0


abstract: UNASSIGNED: @entity3 and perforation are severe complications of @entity5 , which have a challenging preoperative diagnosis. Early identification allows better surgical management. Contrast-enhanced computed tomography (ceCT) is the current diagnostic gold standard. Contrast-enhanced ultrasonography (CEUS) is a promising tool for the diagnosis of @entity2 , but data from the literature concerning efficacy are sparse. The aim of the study was to evaluate CEUS findings in pathologically proven complicated @entity3 ( @entity4 , @entity2 , @entity1 ). A total of 8 @entity0 submitted to preoperative CEUS, and with subsequent proven acute complicated @entity3 at surgical inspection and pathological analysis, were retrospectively identified. The final diagnosis was @entity4 /phlegmonous @entity3 (n. 2), phlegmonous/ulcerative changes plus @entity1 (n. 2), perforated plus @entity1 (n. 3), or perforated plus pericholecystic biliary collection (n. 1). Conventional US findings revealed irregularly thickened gallbladder walls in all 8 @entity0 , with vaguely defined walls in 7 @entity0 , four of whom also had striated wall thickening. CEUS revealed irregular enhancing gallbladder walls in all @entity0 . A distinct wall defect was seen in six @entity0 , confirmed as @entity4 /phlegmonous @entity3 at pathology in all six, and in four as perforation at macroscopic surgical inspection. CEUS is a non-invasive easily repeatable technique that can be performed at the bedside, and is able to accurately diagnose complicated/perforated @entity3 . Despite the limited sample size in the present case series, CEUS appears as a promising tool for the management of @entity0 with the clinical possibility of having an acute complicated @entity3 .

title: Contrast-enhanced ultrasonography to diagnose complicated XXXX .

answer: @entity5


abstract: STUDY DESIGN: Mixed retrospective-prospective cohort study. OBJECTIVES: To determine 2-year survival following discharge from hospital after @entity4 in Bangladesh. SETTING: Bangladesh. METHODS: Medical records were used to identify all @entity0 admitted in 2011 with a recent @entity4 to the Centre for Rehabilitation of the Paralysed, a large Bangladeshi hospital that specialises in care of @entity0 with @entity4 . @entity0 or their families were subsequently visited or contacted by telephone in 2014. Vital status and, where relevant, date and cause of @entity1 were determined by verbal autopsy. RESULTS: 350 of 371 @entity0 admitted with a recent @entity4 in 2011 were discharged alive from hospital. All but eleven were accounted for two years after discharge (97% follow-up). Two-year survival was 87% (95% CI 83% to 90%). Two-year survival of those who were wheelchair-dependent was 81% (95% CI 76% to 86%). The most common cause of @entity1 was @entity2 due to pressure @entity3 . CONCLUSION: In Bangladesh, approximately one in five @entity0 with @entity4 who are wheelchair-dependent die within two years of discharge from hospital. Most @entity1 are due to @entity2 from potentially preventable pressure @entity3 .Spinal Cord advance online publication, 16 June 2015; doi:10.1038/sc.2015.92.

title: Two-year survival following discharge from hospital after XXXX in Bangladesh.

answer: @entity4


abstract: In @entity2 ( @entity2 ) and @entity1 ( @entity1 ) the @entity5 chromosome (22q-) is the most frequent @entity4 encountered. At the molecular level the @entity3 gene from chr. 9 is translocated to the bcr gene on chr. 22. As a result, a chimeric @entity3 gene is generated, which encodes chimeric proteins. Since these proteins are only expressed in @entity5 positive cells, they are per definition @entity0 -specific. In this report we describe the reactivity of polyvalent antisera raised against synthetic peptides corresponding to the @entity0 -specific @entity3 junctions. Native chimeric proteins were specifically recognized by these junction-specific antisera. Therefore we conclude that the @entity3 junctions are antigenically exposed on the chimeric proteins. We discuss the relevance of these antisera for @entity2 and @entity1 diagnosis.

title: Detection of @entity0 -specific antigens in XXXX .

answer: @entity2


abstract: In @entity2 ( @entity2 ) and @entity1 ( @entity1 ) the @entity5 chromosome (22q-) is the most frequent @entity4 encountered. At the molecular level the @entity3 gene from chr. 9 is translocated to the bcr gene on chr. 22. As a result, a chimeric @entity3 gene is generated, which encodes chimeric proteins. Since these proteins are only expressed in @entity5 positive cells, they are per definition @entity0 -specific. In this report we describe the reactivity of polyvalent antisera raised against synthetic peptides corresponding to the @entity0 -specific @entity3 junctions. Native chimeric proteins were specifically recognized by these junction-specific antisera. Therefore we conclude that the @entity3 junctions are antigenically exposed on the chimeric proteins. We discuss the relevance of these antisera for @entity2 and @entity1 diagnosis.

title: Detection of XXXX -specific antigens in @entity2 .

answer: @entity0


abstract: An algorithm is proposed for the conversion of a virtual-bond polypeptide chain (connected C alpha atoms) to an all-atom backbone, based on determining the most extensive @entity3 -bond network between the peptide groups of the backbone, while maintaining all of the backbone atoms in energetically feasible conformations. @entity3 bonding is represented by aligning the peptide-group dipoles. These peptide groups are not contiguous in the @entity2 sequence. The first dipoles to be aligned are those that are both sufficiently close in space to be arranged in approximately linear arrays termed dipole paths. The criteria used in the construction of dipole paths are: to assure good alignment of the greatest possible number of dipoles that are close in space; to optimize the electrostatic interactions between the dipoles that belong to different paths close in space; and to avoid locally unfavorable @entity2 residue conformations. The equations for dipole alignment are solved separately for each path, and then the remaining single dipoles are aligned optimally with the electrostatic field from the dipoles that belong to the dipole-path network. A least-squares minimizer is used to keep the geometry of the alpha- @entity1 trace of the resulting backbone close to that of the input virtual-bond chain. This procedure is sufficient to convert the virtual-bond chain to a real chain; in applications to real systems, however, the final structure is obtained by minimizing the total ECEPP/2 (empirical conformational energy program for peptides) energy of the system, starting from the geometry resulting from the solution of the alignment equations. When applied to model alpha-helical and beta-sheet structures, the algorithm, followed by the ECEPP/2 energy minimization, resulted in an energy and backbone geometry characteristic of these alpha-helical and beta-sheet structures. Application to the alpha- @entity1 trace of the backbone of the crystallographic 5PTI structure of @entity0 pancreatic trypsin inhibitor, followed by ECEPP/2 energy minimization with C alpha-distance constraints, led to a structure with almost as low energy and root mean square deviation as the ECEPP/2 geometry analog of 5PTI, the best agreement between the crystal and reconstructed backbone being observed for the residues involved in the dipole-path network.

title: Calculation of protein backbone geometry from alpha- XXXX coordinates based on peptide-group dipole alignment.

answer: @entity1


abstract: OBJECTIVE: The aim was to study whether basal or cytokine stimulated generation of @entity5 (NO) modulates platelet adhesion to @entity0 umbilical vein endothelial cells (HUVEC). METHODS: The adhesion of 111In labelled @entity0 platelets to transfected HUVEC (SGHEC-7) was measured either alone or after incubation of SGHEC-7 cells for 18 h with @entity6 ( @entity6 ) and/or @entity1 necrosis factor alpha ( @entity2 ). The activity of NO synthase in these cells was measured by formation of @entity10 . The effects of @entity4 (0.3 microM) and @entity9 ( @entity9 , 100 microM) on these two variables were determined. RESULTS: Stimulation of SGHEC-7 cells with @entity6 or @entity2 (each at 1-30 ng.ml-1) caused them to express the @entity8 , an effect that was prevented by @entity4 . Platelet adhesion to unstimulated SGHEC-7 cells was < 0.1% (n = 3) and was increased to 0.7 (SEM 0.2)% by @entity9 but was not affected by @entity4 . Stimulation of the cells with @entity6 and @entity2 @entity7 to a maximum of 2.2(0.4)%. This increase was enhanced by both @entity4 and @entity9 . The effect of @entity9 was prevented by @entity3 . CONCLUSIONS: Inhibition of NO synthesis by @entity9 potentiates platelet adhesion to unstimulated SGHEC-7 cells, showing that basally released NO regulates platelet adhesion. Stimulation of SGHEC-7 cells by cytokines increases their adhesive properties but at the same time causes them to express the @entity8 . @entity5 generated by this enzyme contributes to the modulation of the adhesive properties of the endothelial cells. Thus both constitutive and inducible NO synthases modulate endothelial cell thrombogenicity.

title: Platelet adhesion to @entity0 vascular endothelium is modulated by constitutive and cytokine induced XXXX .

answer: @entity5


abstract: OBJECTIVE: The aim was to study whether basal or cytokine stimulated generation of @entity5 (NO) modulates platelet adhesion to @entity0 umbilical vein endothelial cells (HUVEC). METHODS: The adhesion of 111In labelled @entity0 platelets to transfected HUVEC (SGHEC-7) was measured either alone or after incubation of SGHEC-7 cells for 18 h with @entity6 ( @entity6 ) and/or @entity1 necrosis factor alpha ( @entity2 ). The activity of NO synthase in these cells was measured by formation of @entity10 . The effects of @entity4 (0.3 microM) and @entity9 ( @entity9 , 100 microM) on these two variables were determined. RESULTS: Stimulation of SGHEC-7 cells with @entity6 or @entity2 (each at 1-30 ng.ml-1) caused them to express the @entity8 , an effect that was prevented by @entity4 . Platelet adhesion to unstimulated SGHEC-7 cells was < 0.1% (n = 3) and was increased to 0.7 (SEM 0.2)% by @entity9 but was not affected by @entity4 . Stimulation of the cells with @entity6 and @entity2 @entity7 to a maximum of 2.2(0.4)%. This increase was enhanced by both @entity4 and @entity9 . The effect of @entity9 was prevented by @entity3 . CONCLUSIONS: Inhibition of NO synthesis by @entity9 potentiates platelet adhesion to unstimulated SGHEC-7 cells, showing that basally released NO regulates platelet adhesion. Stimulation of SGHEC-7 cells by cytokines increases their adhesive properties but at the same time causes them to express the @entity8 . @entity5 generated by this enzyme contributes to the modulation of the adhesive properties of the endothelial cells. Thus both constitutive and inducible NO synthases modulate endothelial cell thrombogenicity.

title: Platelet adhesion to XXXX vascular endothelium is modulated by constitutive and cytokine induced @entity5 .

answer: @entity0


abstract: The Augsburg @entity1 Register recorded in 1985, 999 coronary events (734 @entity0 , 265 @entity0 ) occurring in 25-74-year-old residents of the city of Augsburg and the counties of Augsburg and Aichach-Friedberg (study population: 156,489 @entity0 and 171,093 @entity0 ). On average, 444 @entity0 and 138 @entity0 per 100,000 of the population suffered an @entity1 ( @entity1 ) in 1985. The risk of morbidity increased with age in both @entity0 and @entity0 , but gained significance for @entity0 only after their 55th year of life. The 28-day case fatality was 54% for male @entity1 cases and 66% for females; 34% of the @entity1 @entity0 died without ever reaching a hospital. Cardiopulmonary resuscitation (CPR) was attempted by a physician in one-in-three of these out-of-hospital deaths. Although one of two out-of-hospital deaths occurred in the presence of a medical lay @entity0 ; lay CPR was the exception. Broader population education in CPR techniques may thus constitute one method of reducing the number of early @entity1 . The median prehospital time for interviewed hospital @entity0 (66%) was 5 h, and approximately 2 h for @entity0 with systemic thrombolysis (n = 71). The combination of fatal coronary events from the official cause-of-death statistics and the results from the Augsburg register were used to estimate @entity1 morbidity for the whole of the FRG in 1985. This leads to an expected morbidity of 210,000 @entity1 , of which 141,000 @entity1 will be fatal (both sexes).

title: [The XXXX status of a South German population: results of the Augsburg @entity1 register l985].

answer: @entity1


abstract: The Augsburg @entity1 Register recorded in 1985, 999 coronary events (734 @entity0 , 265 @entity0 ) occurring in 25-74-year-old residents of the city of Augsburg and the counties of Augsburg and Aichach-Friedberg (study population: 156,489 @entity0 and 171,093 @entity0 ). On average, 444 @entity0 and 138 @entity0 per 100,000 of the population suffered an @entity1 ( @entity1 ) in 1985. The risk of morbidity increased with age in both @entity0 and @entity0 , but gained significance for @entity0 only after their 55th year of life. The 28-day case fatality was 54% for male @entity1 cases and 66% for females; 34% of the @entity1 @entity0 died without ever reaching a hospital. Cardiopulmonary resuscitation (CPR) was attempted by a physician in one-in-three of these out-of-hospital deaths. Although one of two out-of-hospital deaths occurred in the presence of a medical lay @entity0 ; lay CPR was the exception. Broader population education in CPR techniques may thus constitute one method of reducing the number of early @entity1 . The median prehospital time for interviewed hospital @entity0 (66%) was 5 h, and approximately 2 h for @entity0 with systemic thrombolysis (n = 71). The combination of fatal coronary events from the official cause-of-death statistics and the results from the Augsburg register were used to estimate @entity1 morbidity for the whole of the FRG in 1985. This leads to an expected morbidity of 210,000 @entity1 , of which 141,000 @entity1 will be fatal (both sexes).

title: [The @entity1 status of a South German population: results of the Augsburg XXXX register l985].

answer: @entity1


abstract: OBJECTIVE: Our goal was to evaluate whether treatment of @entity3 during pregnancy with 2% @entity2 vaginal cream reduces the incidence of either @entity1 or low birth weight or of both. STUDY DESIGN: A multicenter, double-blind, randomized, placebo-controlled trial in Indonesia compared a 2% @entity2 vaginal cream with a placebo cream. @entity0 seeking prenatal care at 14 to 26 weeks of gestational age who had @entity3 (Gram stain score > 6 and pH of vaginal fluid > 4.5) were invited to participate. Of the 745 @entity0 enrolled, 681 (91.4%) @entity0 were followed up through delivery. RESULTS: @entity2 vaginal cream was an effective treatment for @entity3 . Two weeks after completion of the treatment, 85.5% of the @entity0 were cured. The rate of @entity1 (< 37 weeks) was 15.0% for @entity2 @entity0 and 13.5% for placebo @entity0 (odds ratio 1.1, 95% confidence interval 0.7 to 1.7). The rate of low birth weight was 9.0% for @entity2 @entity0 and 6.8% for placebo @entity0 (odds ratio 1.3, 95% confidence interval 0.8 to 2.4). CONCLUSIONS: Treatment of @entity3 with @entity2 vaginal cream did not reduce @entity1 or low birth weight. Although @entity2 vaginal cream is an effective treatment for @entity3 , intravaginal treatment would not be effective against @entity3 harbored in the upper genital tract. Systemic treatment may be required to eradicate upper tract infection to reduce @entity1 .

title: Intravaginal @entity2 treatment for @entity3 : effects on XXXX and low birth weight.

answer: @entity1


abstract: OBJECTIVE: Our goal was to evaluate whether treatment of @entity3 during pregnancy with 2% @entity2 vaginal cream reduces the incidence of either @entity1 or low birth weight or of both. STUDY DESIGN: A multicenter, double-blind, randomized, placebo-controlled trial in Indonesia compared a 2% @entity2 vaginal cream with a placebo cream. @entity0 seeking prenatal care at 14 to 26 weeks of gestational age who had @entity3 (Gram stain score > 6 and pH of vaginal fluid > 4.5) were invited to participate. Of the 745 @entity0 enrolled, 681 (91.4%) @entity0 were followed up through delivery. RESULTS: @entity2 vaginal cream was an effective treatment for @entity3 . Two weeks after completion of the treatment, 85.5% of the @entity0 were cured. The rate of @entity1 (< 37 weeks) was 15.0% for @entity2 @entity0 and 13.5% for placebo @entity0 (odds ratio 1.1, 95% confidence interval 0.7 to 1.7). The rate of low birth weight was 9.0% for @entity2 @entity0 and 6.8% for placebo @entity0 (odds ratio 1.3, 95% confidence interval 0.8 to 2.4). CONCLUSIONS: Treatment of @entity3 with @entity2 vaginal cream did not reduce @entity1 or low birth weight. Although @entity2 vaginal cream is an effective treatment for @entity3 , intravaginal treatment would not be effective against @entity3 harbored in the upper genital tract. Systemic treatment may be required to eradicate upper tract infection to reduce @entity1 .

title: Intravaginal @entity2 treatment for XXXX : effects on @entity1 and low birth weight.

answer: @entity3


abstract: OBJECTIVE: Our goal was to evaluate whether treatment of @entity3 during pregnancy with 2% @entity2 vaginal cream reduces the incidence of either @entity1 or low birth weight or of both. STUDY DESIGN: A multicenter, double-blind, randomized, placebo-controlled trial in Indonesia compared a 2% @entity2 vaginal cream with a placebo cream. @entity0 seeking prenatal care at 14 to 26 weeks of gestational age who had @entity3 (Gram stain score > 6 and pH of vaginal fluid > 4.5) were invited to participate. Of the 745 @entity0 enrolled, 681 (91.4%) @entity0 were followed up through delivery. RESULTS: @entity2 vaginal cream was an effective treatment for @entity3 . Two weeks after completion of the treatment, 85.5% of the @entity0 were cured. The rate of @entity1 (< 37 weeks) was 15.0% for @entity2 @entity0 and 13.5% for placebo @entity0 (odds ratio 1.1, 95% confidence interval 0.7 to 1.7). The rate of low birth weight was 9.0% for @entity2 @entity0 and 6.8% for placebo @entity0 (odds ratio 1.3, 95% confidence interval 0.8 to 2.4). CONCLUSIONS: Treatment of @entity3 with @entity2 vaginal cream did not reduce @entity1 or low birth weight. Although @entity2 vaginal cream is an effective treatment for @entity3 , intravaginal treatment would not be effective against @entity3 harbored in the upper genital tract. Systemic treatment may be required to eradicate upper tract infection to reduce @entity1 .

title: Intravaginal XXXX treatment for @entity3 : effects on @entity1 and low birth weight.

answer: @entity2


abstract: AIM: To investigate spleen status in @entity4 and its relationship with @entity3 , Psoriasis Area and Severity Index, and insulin resistance. METHODS: Seventy-nine psoriatic @entity0 who were not suffering from any chronic @entity2 were retrospectively selected for inclusion in this study, and their complete medical records were accessed. An age- and sex-matched group of 80 non-psoriatic, @entity1 @entity0 was included as a control. The following relevant data were collected: age, sex, weight, height, body mass index, waist circumference, blood pressure, insulin resistance status, age at @entity4 onset, and severity of @entity4 . Abdominal ultrasonography was performed to determine spleen longitudinal diameter (SLD), and @entity3 grade. RESULTS: The SLD of control @entity1 @entity0 was greater than that of psoriatic subjects (P = 0.013), but body mass index predicted the size of the spleen in psoriatic @entity0 (P < 0.001). The SLD of psoriatic @entity0 with normal weight was significantly reduced with respect to the overweight/ @entity1 psoriatic @entity0 (P = 0.002). A multiple regression analysis revealed that body mass index was a unique predictor of the spleen size (P < 0.001). Finally, the disease duration predicted the spleen size in psoriatic subjects (P = 0.038). CONCLUSION: This study shows a correlation between the SLD and the duration of @entity4 .

title: Nonalcoholic fatty liver disease, spleen and XXXX : New aspects of low-grade chronic @entity2 .

answer: @entity4


abstract: AIM: To investigate spleen status in @entity4 and its relationship with @entity3 , Psoriasis Area and Severity Index, and insulin resistance. METHODS: Seventy-nine psoriatic @entity0 who were not suffering from any chronic @entity2 were retrospectively selected for inclusion in this study, and their complete medical records were accessed. An age- and sex-matched group of 80 non-psoriatic, @entity1 @entity0 was included as a control. The following relevant data were collected: age, sex, weight, height, body mass index, waist circumference, blood pressure, insulin resistance status, age at @entity4 onset, and severity of @entity4 . Abdominal ultrasonography was performed to determine spleen longitudinal diameter (SLD), and @entity3 grade. RESULTS: The SLD of control @entity1 @entity0 was greater than that of psoriatic subjects (P = 0.013), but body mass index predicted the size of the spleen in psoriatic @entity0 (P < 0.001). The SLD of psoriatic @entity0 with normal weight was significantly reduced with respect to the overweight/ @entity1 psoriatic @entity0 (P = 0.002). A multiple regression analysis revealed that body mass index was a unique predictor of the spleen size (P < 0.001). Finally, the disease duration predicted the spleen size in psoriatic subjects (P = 0.038). CONCLUSION: This study shows a correlation between the SLD and the duration of @entity4 .

title: Nonalcoholic fatty liver disease, spleen and @entity4 : New aspects of low-grade chronic XXXX .

answer: @entity2


abstract: AIM: To review and assess the evidence related to cetuximab treatment in metastatic @entity1 (mCRC) with regard to @entity6 status. METHODS: PubMed, EMBASE, Cochrane database and American Society of Clinical Oncology meeting abstracts were searched for randomized controlled trials (RCTs) reporting the effect of @entity6 status on efficacy of chemotherapy regimen with or without cetuximab in mCRC. Baseline information such as sex and age was summarized from the included studies. Hazard ratios of progression-free survival (PFS) and @entity7 ( @entity7 ) as well as objective response based on @entity6 status were extracted for analysis. RESULTS: A total of 8 RCTs with 6780 @entity0 were included. The combined analysis showed that cetuximab failed to improve the @entity7 and PFS in @entity0 with mCRC. However, in subgroup analysis, the pooled data showed that addition of cetuximab to @entity9 containing chemotherapy regimen was sufficient to improve @entity7 and PFS in wild-type @entity6 mCRC @entity0 , but not in @entity0 with mutant-type @entity6 . The addition of cetuximab increased the incidence of adverse events such as @entity3 , @entity8 , skin @entity2 / @entity8 , and @entity4 and @entity5 . There was no significant publication bias existing in the included studies. CONCLUSION: The clinical benefit of cetuximab was only confirmed in @entity0 with wild-type @entity6 . @entity6 status could be considered a biomarker of efficacy of cetuximab.

title: Standard chemotherapy with cetuximab for treatment of XXXX .

answer: @entity1


abstract: @entity6 is a rare @entity5 with a distinctive histologic appearance that generally affects @entity0 and young @entity0 . We have studied 14 cases of @entity6 and reviewed 41 previously reported examples. Nine of our cases occurred in @entity0 (from newborn to 4 years old; mean, 2.4), and five affected adults (from 19 to 56 years old; mean, 40). There were 8 male cases and 6 female cases. Most @entity0 presented with incidental abdominal masses, although @entity3 , @entity4 , and @entity7 were present, but rarely. The @entity2 were very cellular microscopically, with cytologically uniform epithelial cells arranged in sheets and nests. Well-formed acinar structures were a consistent feature, and several cases contained ectatic ductular formations, rarely exhibiting intracellular mucin. Consistently present were squamoid corpuscles: circumscribed, whorled nests of plump spindle cells with a squamous appearance and occasional keratinization. The stroma was moderate to abundant and frequently quite cellular (especially in the pediatric cases). By immunohistochemistry, the @entity2 exhibited acinar, endocrine, and ductal differentiation, with positivity for pancreatic enzymes (100%), endocrine markers (82%), and carcinoembryonic antigen (85%). Ultrastructural examination most commonly revealed acinar differentiation, although mucigen granules and neurosecretory granules were also occasionally found. The behavior was variable: 36% of @entity0 developed @entity1 , especially to the liver. The adult @entity0 did poorly: three of five died of @entity2 (mean survival, 18 months), and two were alive at 5 and 15 months, respectively. In contrast, five of the six evaluable pediatric @entity0 were alive from 22 months to 22 years after diagnosis, and only one died of @entity2 after 16 months. Good responses to chemotherapy were noted in the pediatric group.

title: XXXX . A clinicopathologic study and review of the literature.

answer: @entity6


abstract: (Full text is available at http://www.manu.edu.mk/prilozi). With the introduction of new techniques in diagnostic and interventional radiology and progress in micro neurosurgery, accurate knowledge of the brain blood vessels is essential for daily clinical work. The aim of this study was to describe the morphological characteristics of the @entity1 and to emphasize their clinical significance. In this study we examined radiographs of 109 @entity0 who had CT angiography at the University Clinic for Radiology in Skopje, R. Macedonia. This study included 49 females and 60 males, ranging in age from 27 to 83 years; mean age 57.4    11.8 years. In 105 @entity0 SCA arose from the basilar artery on both sides as a single vessel. In two @entity0 SCA arose as a duplicate trunk from the basilar artery. We found unilateral duplication on the right SCA in one @entity0 , and bilateral duplication in one @entity0 . In two @entity0 was noticed origin of the SCA from PCA as a single trunk from adult type of the PCA. Through knowledge of the anatomy and variations of SCA is important for clinicians as well as basic scientists who deal with problems related to intracranial vasculature in daily basis for save performance of diagnostic and interventional procedures. Key words: @entity1 , anatomy, variations, basilar artery.

title: Morphological characteristics of the XXXX .

answer: @entity1


abstract: Although @entity4 tattooing is now a well-accepted step in breast reconstruction, little is known about its long-term effectiveness. A retrospective study of our 6-year experience in tattooing 151 @entity0 was thus carried out. @entity0 were surveyed regarding color match, satisfaction, and complications. Follow-up ranged from 1 to 75 months (mean, 25.2 months). Fifty-seven percent of respondents said their tattoo looked similar to the normal areola. There were five (3%) @entity1 , one @entity2 , and one slough. Ten percent of tattoos needed a touch-up later to correct for excessive fading. Nearly 60% of tattoos were ultimately lighter than the normal. Eighty-four percent of the tattoos were rated as satisfactory, and 86% of the @entity0 said they would repeat the procedure if given the same choice again. Nipple-areola tattooing done with @entity3 and @entity5 pigments thus appears to be a reasonably safe and effective procedure in most @entity0 but may require one or more subsequent touch-ups for appropriate color match.

title: Long-term experience with XXXX tattooing.

answer: @entity4


abstract: PURPOSE: Recently, a novel multi-model monitor has been available, which integrates real-time signals of transcranial Doppler (TCD) and video-EEG (vEEG) into one workstation. We sought to test the feasibility of this device in detecting @entity3 in @entity0 with @entity1 . METHOD: Cerebral blood flow velocity (CBFV) of bilateral middle cerebral arteries and vEEG during @entity2 episodes were recorded simultaneously in 12 @entity0 (age 17-58 years) with @entity1 . The correlations between vEEG and CBFV findings were analyzed. RESULTS: Eleven @entity2 episodes were detected in 5 @entity0 . Of them, bilateral CBFV increase with interhemispheric asymmetry was observed in 4 @entity2 episodes of 3 @entity0 . EEG abnormalities preceded CBFV increase by 1-3s at the onset of a @entity2 . In a @entity0 with bilateral @entity5 , no apparent CBFV changes were detected during 2 of 3 @entity2 episodes. Another @entity0 with previous frontal @entity4 displayed CBFV increase without interhemispheric asymmetry during 4 @entity2 episodes. CONCLUSION: It is feasible to evaluate @entity3 with good temporal correlation in @entity0 with frequent @entity2 episodes by real-time TCD-vEEG monitoring.

title: Real-time TCD-vEEG monitoring for XXXX in @entity1 .

answer: @entity3


abstract: PURPOSE: Recently, a novel multi-model monitor has been available, which integrates real-time signals of transcranial Doppler (TCD) and video-EEG (vEEG) into one workstation. We sought to test the feasibility of this device in detecting @entity3 in @entity0 with @entity1 . METHOD: Cerebral blood flow velocity (CBFV) of bilateral middle cerebral arteries and vEEG during @entity2 episodes were recorded simultaneously in 12 @entity0 (age 17-58 years) with @entity1 . The correlations between vEEG and CBFV findings were analyzed. RESULTS: Eleven @entity2 episodes were detected in 5 @entity0 . Of them, bilateral CBFV increase with interhemispheric asymmetry was observed in 4 @entity2 episodes of 3 @entity0 . EEG abnormalities preceded CBFV increase by 1-3s at the onset of a @entity2 . In a @entity0 with bilateral @entity5 , no apparent CBFV changes were detected during 2 of 3 @entity2 episodes. Another @entity0 with previous frontal @entity4 displayed CBFV increase without interhemispheric asymmetry during 4 @entity2 episodes. CONCLUSION: It is feasible to evaluate @entity3 with good temporal correlation in @entity0 with frequent @entity2 episodes by real-time TCD-vEEG monitoring.

title: Real-time TCD-vEEG monitoring for @entity3 in XXXX .

answer: @entity1


abstract: PURPOSE: This study aimed to chart patterns of simultaneous trajectories over 8  months in @entity0 survivors' (BCS) supportive care needs, @entity4 , social support, and posttraumatic growth. Clusters of BCS among these trajectories were identified and characterized. METHODS: Of 426 BCS study @entity1 , 277 (65  %) provided full assessments in the last week of primary @entity2 treatment and 4 and 8  months later. Latent trajectories were obtained using growth mixture modeling for @entity1 who responded to all scores for at least one time point (n   =   348). Then, classification of BCS was performed by hierarchical agglomerative clustering on axes derived from a multiple factor analysis of trajectory assignments. Self-esteem, attachment security, and satisfaction with care were assessed at baseline. RESULTS: Four trajectory clusters were identified, including two BCS subgroups (63  %) with low needs and @entity3 . Two others (37  %) exhibited high or increasing needs and concerning levels of @entity4 . These latter clusters were characterized by higher insecure attachment, lower satisfaction with care, and either lower education or younger age, and having undergone chemotherapy. CONCLUSION: More than a third of BCS present unfavorable patterns in supportive care needs over 8  months after primary @entity2 treatment. Identified @entity2 care characteristics point to targets for enhanced BCS supportive care.

title: Identifying trajectory clusters in XXXX survivors' supportive care needs, psychosocial difficulties, and resources from the completion of primary treatment to 8  months later.

answer: @entity0


abstract: BACKGROUND: The epidemiology of suicidality shows considerable variation across sites. However, one of the strongest predictors of suicide is a suicidal attempt. Knowledge of the epidemiology of suicidal ideas and attempts in the general population as well as in the health care system is of importance for designing preventive strategies. In this study, we will explore the role of the @entity1 hospital in suicide prevention by investigating treated incidence of suicidal ideation and attempt, and further, discern whether sociodemographic, clinical and service utilization factors differ between these two groups at admission. METHODS: The study was a prospective cohort study on treated incidence in a 1-year period and 12-month follow-up. The two @entity1 hospitals in northern Norway, serving a population of about 500,000 @entity0 , participated in the study. A total of 676 first-time admissions were retrospectively checked for suicidality at the time of admission. A study sample of 168 @entity0 was found eligible for logistic regression analysis to elucidate the risk profiles of suicidal ideators versus suicidal attempters. GAF, HoNOS and SCL-90-R were used to assess symptomatology at baseline. RESULTS: 52.2% of all @entity0 admitted had suicidal ideas at admission and 19.7% had attempted suicide. In the study sample, there were no differences in risk profile between the two groups with regard to sociodemographic and clinical factors. Males who had made a suicide attempt were less likely to have been in contact with an out- @entity0 clinic before the attempt. The rating scales not measuring suicidality directly showed no differences in symptomatology. CONCLUSION: The findings provide evidence for the importance of the @entity1 hospital in suicide prevention. About half of the admissions were related to suicidality and the similar risk profiles found in suicidal ideators and suicidal attempters indicate that it is the ideators who mostly need treatment that get admitted to the hospital, and should be evaluated and treated with equal concern as those who have attempted suicide.

title: Suicidality related to first-time admissions to XXXX hospital.

answer: @entity1


abstract: The female genital tract (FGT) harbors very large numbers of bacterial species that are known to play an important role on vaginal health. Previous studies have focused on bacterial diversity in the vagina, but little is known about the ectocervical microbiota associated with @entity2 . In our study, vaginal swabs and ectocervical swabs were collected from 100 @entity0 in China, including 30 @entity0 with @entity3 ( @entity3 ; @entity3 group), 22 @entity0 with @entity1 (Cer group), 18 @entity0 with @entity3 in combination with @entity1 (BC group) and 30 healthy control @entity0 (CN group). The diversity and richness of cervicovaginal microbiota were investigated with culture-independent polymerase chain reaction (PCR)-denaturing gradient gel electrophoresis (DGGE) and quantitative PCR (qPCR) targeting 11 microorganisms that have been associated with @entity2 . Despite significant interpersonal variations, the PCR-DGGE profiles revealed that vaginal microbiota and ectocervical microbiota were clearly much more complex in the @entity3 group, while the ectocervical microbiota showed no significant difference between healthy and diseased @entity0 . Using species-specific qPCR, @entity3 and @entity1 were significantly associated with a dramatic decrease in Lactobacillus species (p   <   0.05), and potential pathogenic species such as Gardnerella, Atopobium, Eggerthella, Leptotrichia/Sneathia, and Prevotella were more common and in higher copy numbers in @entity3 than in CN samples (p values ranged from 0.000 to 0.021). No significant differences were observed between healthy and @entity1 samples (p   >   0.05) in ectocervical microbiota. The total numbers of bacteria were significantly lower in the ectocervix as compared in the vagina (p   <   0.05). Intriguingly, vaginal microbiota from @entity0 with @entity3 in combination with @entity1 was quite different from that of @entity0 with @entity3 or @entity1 alone. Our study demonstrated that the cervicovaginal microbiota was actively involved in the process of @entity2 . The predominant bacteria of the cervicovaginal communities were clearly associated with @entity3 ; however, there was not sufficient evidence that the ectocervical microbiota is directly involved in the development of @entity1 .

title: Diversity of cervicovaginal microbiota associated with XXXX .

answer: @entity2


abstract: The variegated Saintpaulia cultivar Thamires (Saintpaulia sp.), which has pink petals with blue splotches, is generally maintained by leaf cuttings. In contrast, tissue culture-derived progeny of the cultivar showed not only a high percentage of mutants with solid-blue petals but also other solid-color variants, which have not been observed from leaf cuttings. Solid-color phenotypes were inherited stably by their progeny from tissue culture. Petals from each solid-color variant were analyzed by high-performance liquid chromatography and shown to contain different proportions of three main @entity1 derivatives: @entity2 , @entity4 , and @entity3 . Analysis of @entity0 3', 5'-hydroxylase (F3'5'H) sequences showed no differences in the coding region among the variants and variegated individuals. However, a transposon belonging to the hAT superfamily was found in the promoter region of variegated individuals, and the presence of transposon-related insertions or deletions correlated with the observed flower-color phenotypes. Solid-blue flower mutants contained 8-base pair (bp) insertions (transposon excision footprints), while solid-pink mutants had 58- to 70-bp insertions, and purple- and deep-purple mutants had 21- and 24-bp deletions, respectively. Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis showed that F3'5'H expression levels correlated with insertions and deletions (indels) caused by hAT excision, resulting in flower-color differences. Our results showed that tissue culture of Saintpaulia 'Thamires' elicits transposon excision, which in turn alters F3'5'H expression levels and flower colors.

title: Tissue culture-induced flower-color changes in Saintpaulia caused by excision of the transposon inserted in the XXXX 3', 5' hydroxylase (F3'5'H) promoter.

answer: @entity0


abstract: A series of 98 @entity0 with a total of 105 @entity8 were operated on during a 10-year period between 1983 and 1992. We were able to follow up 60 @entity0 with 64 @entity3 an average of 44 months (range, 18-105 months) postoperatively. At the time of follow up, 83.9% of @entity0 had been back to work, 78.6% with the same employer as before. Five of the @entity0 followed up had had to retire from work; each of these had one or more severe coexisting @entity2 . A compromising @entity1 occurred postoperatively in 3 out of 58 @entity0 with @entity6 , in all cases following surgery with a medial or bilateral approach. In only 1 of the 58 @entity0 followed up after @entity6 did a @entity4 requiring arthrodesis occur. One @entity0 had sympathetic @entity7 (Sudeck). A good functional result in the lower ankle joint correlated with a good outcome. In contrast, postoperative improvement of the tuber angle and the degree of @entity5 seen radiographically did not. We conclude that operative repair of intraarticular calcaneal @entity3 is a procedure that can safely be procedure used to restore the ability to work in the majority of @entity0 . The medial approach should preferably not be used, nor should the metal be extracted from the medial approach if this can be avoided.

title: [Dislocated intra-articular calcaneus XXXX . Long-term follow-up after open reposition and osteosynthesis].

answer: @entity3


abstract: @entity1 profiles were monitored in @entity0 housed in single (n = 9) or group (n = 14) pens during winter (JJA) and spring ( @entity2 ). Normal cycles (n = 97) were < or = 30 days. Extended cycles (n = 45) were > 30 days and, except for one cycle with a persistent corpus luteum, had periovulatory periods of 10 to 20 days (n = 29) or averaging 65.1 days in length (n = 15), mostly characterised by recurrent oestrus and/or occasional transient rises in @entity1 . The proportion of normal cycles occurring in winter was 87.5% (28/32) and 77.7% (42/54) for @entity0 in single and group pens respectively, falling to 62.5% (15/24) and 37.5% (12/32) respectively in spring. The distribution of normal vs extended cycles according to season was significant (P < 0.05, single; P < 0.001 group pens). @entity0 housed communally experienced a greater fall in the percentage of normal cycles in spring, possibly due to increased stress associated with group feeding. Within each season, however, housing per se did not influence the distribution of normal vs extended cycles. For normal cycles, Harvey's Analysis of Variance showed that season was significantly associated with length of the periovulatory period (3.99 days (JJA) vs 5.79 days ( @entity2 ); P < 0.001), oestrus detection rate (87% (JJA) vs 55% ( @entity2 ); P < 0.01) and oestrus duration (1.94 days (JJA) vs 1.13 days ( @entity2 ); P < 0.05). In contrast, luteal phase length was not affected by season, but was significantly associated with housing (16.93 days (single pens) vs 18.32 days (group pens); P < 0.01). The reduction in ovarian activity observed in spring may reflect a seasonal reduction in fertility, possibly linked with increasing temperature and photoperiod.

title: Influence of season and housing on ovarian activity of indigenous XXXX in Zimbabwe.

answer: @entity0