abstract: This case report describes a mitral systolic honk originating from the mitral valve and adjacent structures in a 52 year-old @entity0 with @entity2 . The @entity0 was hospitalized because of @entity1 . Auscultation of the heart revealed a grade 3/6 apical early systolic honk accompanied by an increased first heart sound, an opening snap and a diastolic rumble. The phonocardiogram demonstrated an early systolic honk at a frequency of 115 Hz. Intensity of the honk varied on beat to beat basis, increasing in the short preceding R-R interval compared to that in the long one. The M-mode echocardiogram showed early systolic fluttering of the mitral valve and chordae tendineae at the same frequency as the honk. The two-dimensional echocardiogram showed bulging of the anterior mitral leaflet toward the left atrium in early systole. After treatment with digitalis and diuretics, the early systolic honk disappeared in beats with preceding long R-R intervals (greater than 1100 msec). In beats without the honk, systolic fluttering of the mitral valve was not observed. The genesis of the early systolic honk is analogous to that of the honk audible in mitral or @entity3 . The bulging of the anterior mitral leaflet into the left atrium may produce vibrations of the mitral valve leaflets and adjacent structures.

title: [Systolic honk in XXXX : a case report].

answer: @entity2


abstract: @entity6 ( @entity6 ) is a clinical @entity4 characterized by progressive decline in language function but relative sparing of other cognitive domains. There are three recognized @entity6 variants: agrammatic, semantic, and logopenic. Although each @entity6 subtype is characterized by the nature of the principal deficit, individual @entity0 frequently display @entity1 in additional language domains. The present study investigated the distribution of @entity3 related to performance in specific language domains (i.e., grammatical processing, semantic processing, fluency, and sentence repetition) across @entity6 variants to better understand the anatomical substrates of language. Results showed regionally specific relationships, primarily in the left hemisphere, between @entity3 and impairments in language performance. Most notable was the neuroanatomical distinction between fluency and grammatical processing. Poor fluency was associated with regions dorsal to the traditional boundaries of Broca's area in the inferior frontal sulcus and the posterior middle frontal gyrus, whereas grammatical processing was associated with more widespread @entity3 , including the @entity2 . Repetition performance was correlated with @entity3 in the posterior superior temporal gyrus. The correlation of @entity3 with semantic processing impairment was localized to the anterior temporal poles. Atrophy patterns were more closely correlated with domain-specific performance than with subtype. These results show that @entity6 reflects a selective disruption of the language network as a whole, with no rigid boundaries between subtypes. Further, these @entity3 patterns reveal anatomical correlates of language that could not have been surmised in @entity0 with @entity5 resulting from @entity2 .

title: Anatomy of @entity1 in XXXX .

answer: @entity6


abstract: @entity6 ( @entity6 ) is a clinical @entity4 characterized by progressive decline in language function but relative sparing of other cognitive domains. There are three recognized @entity6 variants: agrammatic, semantic, and logopenic. Although each @entity6 subtype is characterized by the nature of the principal deficit, individual @entity0 frequently display @entity1 in additional language domains. The present study investigated the distribution of @entity3 related to performance in specific language domains (i.e., grammatical processing, semantic processing, fluency, and sentence repetition) across @entity6 variants to better understand the anatomical substrates of language. Results showed regionally specific relationships, primarily in the left hemisphere, between @entity3 and impairments in language performance. Most notable was the neuroanatomical distinction between fluency and grammatical processing. Poor fluency was associated with regions dorsal to the traditional boundaries of Broca's area in the inferior frontal sulcus and the posterior middle frontal gyrus, whereas grammatical processing was associated with more widespread @entity3 , including the @entity2 . Repetition performance was correlated with @entity3 in the posterior superior temporal gyrus. The correlation of @entity3 with semantic processing impairment was localized to the anterior temporal poles. Atrophy patterns were more closely correlated with domain-specific performance than with subtype. These results show that @entity6 reflects a selective disruption of the language network as a whole, with no rigid boundaries between subtypes. Further, these @entity3 patterns reveal anatomical correlates of language that could not have been surmised in @entity0 with @entity5 resulting from @entity2 .

title: Anatomy of XXXX in @entity6 .

answer: @entity1


abstract: OBJECTIVE: To validate polymerase chain reaction (PCR) analysis for detecting HPV in Mexican @entity0 with @entity2 , grade 2 and 3 (CIN 2/3) versus histologic evidence. STUDY DESIGN: A diagnostic test study was carried out. A sample of 25 selected @entity0 who were diagnosed by histology as having CIN 2/3 was analyzed. Biopsies were examined for @entity1 using light microscopy. The histologic criteria used for @entity1 included koilocytosis, @entity3 cells, bi/multinucleation, and @entity4 . PCR was performed on each sample using commercial probes (MY09 and MY11), and then HPV typing was carried out by restriction fragment length polymorphism analyses. RESULTS: PCR revealed that 88% (22/25) of the @entity0 were HPV positive (19 high risk and 3 low risk). In contrast, histology revealed that 28% (7/25) of the @entity0 were HPV positive. The number of @entity0 infected with HPV was 3.14 times (88/28) more frequently detected with PCR procedure than with the histology. Using PCR as the gold standard, 4 values (true positive, false positive, false negative and true negative) were obtained (7, 0, 15 and 3), and histology had a sensitivity, specificity, and positive and negative predictive values of .32, 1.00, 1.00 and .17, respectively. There was a correlation between low-risk and high-risk for PCR (chi 2 with Yates correction = 6.32, P = .012). CONCLUSION: PCR is a powerful tool for the early detection of @entity1 and is independent of histologic criteria.

title: Validating polymerase chain reaction for detecting HPV in XXXX .

answer: @entity2


abstract: BACKGROUND: Endothelial progenitor cells (EPCs) have been implicated in neoangiogenesis, endothelial repair and cell-based therapies for @entity1 . We have previously shown that the recruitment of EPCs to sites of @entity2 is facilitated by platelets where EPCs, in turn, modulate platelet function and @entity3 . However, EPCs encompass a heterogeneous population of progenitor cells that may exert different effects on platelet function. Recent evidence suggests the existence of two EPC subtypes: early outgrowth cells (EOCs) and endothelial colony-forming cells (ECFCs). We aimed at characterizing these two EPC subtypes and at identifying their role in @entity5 . METHODS: EOCs and ECFCs were generated from @entity0 peripheral blood mononuclear cells (PBMCs) seeded in conditioned media on fibronectin and collagen, respectively. The morphological, phenotypical and functional characteristics of EOCs and ECFCs were assessed by optical and confocal laser scanning microscopes, cell surface markers expression, and Matrigel tube formation. The impact of EOCs and ECFCs on @entity5 was monitored in collagen-induced optical aggregometry and compared with PBMCs and @entity0 umbilical vein endothelial cells (HUVECs). The levels of the anti-platelet agents' @entity4 (NO) and @entity7 ( @entity7 ) released from cultured cells as well as the expression of their respective producing enzymes NO synthases (NOS) and cyclooxygenases (COX) were also assessed. RESULTS: We showed that EOCs display a monocytic-like phenotype whereas ECFCs have an endothelial-like phenotype. We demonstrated that both EOCs and ECFCs and their supernatants inhibited @entity5 ; however ECFCs were more efficient than EOCs. This could be related to the release of significantly higher amounts of NO and @entity7 from ECFCs, in comparison to EOCs. Indeed, ECFCs, like HUVECs, constitutively express the endothelial (eNOS)-and inducible (iNOS)-NOS isoforms, and @entity8 and weakly express @entity6 , whereas EOCs do not constitutively express these NO and @entity7 producing enzymes. CONCLUSION: The different morphological, phenotypic and more importantly the release of the anti-aggregating agents @entity7 and NO in each EPC subtype are implicated in their respective roles in platelet function and thus, may be linked to the increased efficiency of ECFCs in inhibiting @entity5 as compared to EOCs.

title: Early outgrowth cells versus endothelial colony forming cells functions in XXXX .

answer: @entity5


abstract: UNASSIGNED: Proteomics studies typically analyze proteins at a population level, using extracts prepared from tens of thousands to millions of cells. The resulting measurements correspond to average values across the cell population and can mask considerable variation in protein expression and function between individual cells or organisms. Here, we report the development of micro-proteomics for the analysis of @entity1 , a eukaryote composed of 959 somatic cells and    1,500 germ cells, measuring the worm proteome at a single organism level to a depth of     3,000 proteins. This includes detection of proteins across a wide dynamic range of expression levels (> 6 orders of magnitude), including many chromatin-associated factors involved in chromosome structure and gene regulation. We apply the micro-proteomics workflow to measure the global proteome response to @entity0 in individual @entity1 . This shows variation between individual animals in the magnitude of proteome response following @entity0 , including variable induction of @entity0 . The micro-proteomics pipeline thus facilitates the investigation of stochastic variation in protein expression between individuals within an isogenic population of @entity1 . All data described in this study are available online via the Encyclopedia of Proteome Dynamics (http://www.peptracker.com/epd), an open access, searchable database resource. This article is protected by copyright. All rights reserved.

title: Micro-proteomics with iterative data analysis: proteome analysis in XXXX at the single worm level.

answer: @entity1


abstract: PURPOSE: This study explored a causal model explaining @entity1 @entity0 currently undertaking Chemotherapy. METHOD: In this cross-sectional study, a convenience sample of 246 @entity1 @entity0 were recruited from six Oncology centers throughout the north of Vietnam. The hypothesized model, consisting of @entity2 , @entity5 , cough, @entity3 , stage of disease, physical activity, nutritional status, and number of completed chemotherapy cycles, was constructed based on Piper's Integrated Fatigue Model and a review of the literature. RESULTS: All factors, except the number of completed chemotherapy cycles significantly affected @entity4 . The hypothesized model explained 42.9% of @entity4 variance. @entity5 had the largest total effect on @entity4 (b  =  0.397, p  <  0.01), followed by cough (b  =  0.343, p  <  0.01), @entity2 (b  =  0.318 (p  <  0.01), and @entity3 (b  =  0.115, p  <  0.05). However, @entity2 had the greatest direct effect on @entity4 . There was also interplay among those four factors in determining @entity4 . Physical activity and nutrition status had small effects on @entity4 (b  =  - 0.148, p  <  0.01 and b  =  - 0.156, p  <  0.01). CONCLUSION: The model fits well to explain @entity4 . Having the largest direct effect on @entity4 , @entity2 appeared as a factor of choice for future @entity4 control programs. Due to its higher direct effect on @entity4 , @entity5 was recommended over cough for @entity4 management. Additionally, the interactions among @entity4 , @entity5 , and cough suggested that comprehensive programs, which simultaneously address these three symptoms, would be a promising approach for practitioners to consider.

title: A causal model for XXXX @entity0 receiving chemotherapy.

answer: @entity1


abstract: PURPOSE: This study explored a causal model explaining @entity1 @entity0 currently undertaking Chemotherapy. METHOD: In this cross-sectional study, a convenience sample of 246 @entity1 @entity0 were recruited from six Oncology centers throughout the north of Vietnam. The hypothesized model, consisting of @entity2 , @entity5 , cough, @entity3 , stage of disease, physical activity, nutritional status, and number of completed chemotherapy cycles, was constructed based on Piper's Integrated Fatigue Model and a review of the literature. RESULTS: All factors, except the number of completed chemotherapy cycles significantly affected @entity4 . The hypothesized model explained 42.9% of @entity4 variance. @entity5 had the largest total effect on @entity4 (b  =  0.397, p  <  0.01), followed by cough (b  =  0.343, p  <  0.01), @entity2 (b  =  0.318 (p  <  0.01), and @entity3 (b  =  0.115, p  <  0.05). However, @entity2 had the greatest direct effect on @entity4 . There was also interplay among those four factors in determining @entity4 . Physical activity and nutrition status had small effects on @entity4 (b  =  - 0.148, p  <  0.01 and b  =  - 0.156, p  <  0.01). CONCLUSION: The model fits well to explain @entity4 . Having the largest direct effect on @entity4 , @entity2 appeared as a factor of choice for future @entity4 control programs. Due to its higher direct effect on @entity4 , @entity5 was recommended over cough for @entity4 management. Additionally, the interactions among @entity4 , @entity5 , and cough suggested that comprehensive programs, which simultaneously address these three symptoms, would be a promising approach for practitioners to consider.

title: A causal model for @entity1 XXXX receiving chemotherapy.

answer: @entity0


abstract: We have studied the formation of experimental B16 @entity3 metastases in the lungs of @entity2 inoculated IV with tumoricidal or nontumoricidal peritoneal macrophages elicited by various agents. IV inoculation of peritoneal M phi elicited by Brewer's thioglycollate medium (TG-M phi) 1 day before the injection of B16 @entity3 cells dramatically increased the number of metastatic foci in the lungs. NIH thioglycollate broth and proteose peptone each elicited a relatively low number of M phi, which were morphologically distinguishable from TG-M phi and did not influence the yield of B16 @entity3 colonies in the lungs. Resident or C. pravum-elicited M phi also did not augment @entity0 formation. TG-M phi became highly tumoricidal after IP stimulation with poly I:C. However, tumoricidal TG-M phi inoculated IV 1 day before IV inoculation of B16 @entity3 cells did not have an antimetastatic effect. On the contrary, both tumoricidal and nontumoricidal TG-M phi augmented @entity0 formation. Poly I:C treatment had a substantial antimetastatic effect in the normal @entity2 , but not in @entity2 with adoptively transferred TG-M phi. Histological analysis revealed that IV-inoculated TG-M phi (tumoricidal or nontumoricidal, either viable or disrupted) induced severe intravascular reaction in the lungs, but not in the liver or kidney. This reaction manifested in the aggregation of the various blood cells, preferentially neutrophils. These reactions were not observed after IV inoculation of PM phi or NIH TG-M phi. Intravascular inflammatory reactions induced by TG-M phi may be responsible for the augmentation of @entity0 formation, partly by suppression of NK reactivity and mostly by the acceleration of the processes of @entity1 cell extravasation. These data may provide some insight into the failure to achieve systemic adoptive immunotherapy using activated peritoneal TG-M phi.

title: Modulation of formation of XXXX metastases by peritoneal macrophages elicited by various agents.

answer: @entity1


abstract: BACKGROUND: The QT interval measures cardiac repolarization, and prolongation is associated with adverse cardiovascular outcomes and @entity2 . The exponential Bazett correction formula overestimates the QT interval during @entity4 . OBJECTIVE: We evaluated 4 formulas of @entity7 in individuals with @entity9 for the identification of @entity3 , @entity5 , and mortality. METHODS: The Penn @entity6 Free study is a large cohort study of @entity0 without @entity6 . The present study examined 6723 Penn @entity6 Free study @entity0 without a history of @entity5 and with baseline @entity1 rate >= 100 beats/min. Medical records were queried for index clinical parameters, incident cardiovascular events, and all-cause mortality. The QT interval was corrected by using Bazett (QT/RR(0.5)), Fridericia (QT/RR(0.33)), Framingham [QT + 0.154 * (1000 - RR)], and Hodges (QT + 105 * (1/ @entity8 )) formulas. RESULTS: In 6723 @entity0 with a median follow-up of 4.5 years (interquartile range 1.9-6.4 years), the annualized cardiovascular event rate was 2.3% and the annualized mortality rate was 2.2%. QT prolongation was diagnosed in 39% of the cohort using the Bazett formula, 6.2% using the Fridericia formula, 3.7% using the Framingham formula, and 8.7% using the Hodges formula. Only the Hodges formula was an independent risk marker for @entity2 across the range of QT values (highest tertile: hazard ratio 1.26; 95% confidence interval 1.03-1.55). CONCLUSION: Although all correction formulas demonstrated an association between QTc values and cardiovascular events, only the Hodges formula identified one-third of individuals with @entity4 that are at higher risk of all-cause mortality. Furthermore, the Bazett correction formula overestimates the number of @entity0 with a prolonged QT interval and was not associated with mortality. Future work may validate these findings and result in changes to automated algorithms for QT interval assessment.

title: Optimal @entity7 formula in XXXX for identifying cardiovascular and mortality risk: Findings from the Penn @entity6 Free study.

answer: @entity9


abstract: BACKGROUND: The QT interval measures cardiac repolarization, and prolongation is associated with adverse cardiovascular outcomes and @entity2 . The exponential Bazett correction formula overestimates the QT interval during @entity4 . OBJECTIVE: We evaluated 4 formulas of @entity7 in individuals with @entity9 for the identification of @entity3 , @entity5 , and mortality. METHODS: The Penn @entity6 Free study is a large cohort study of @entity0 without @entity6 . The present study examined 6723 Penn @entity6 Free study @entity0 without a history of @entity5 and with baseline @entity1 rate >= 100 beats/min. Medical records were queried for index clinical parameters, incident cardiovascular events, and all-cause mortality. The QT interval was corrected by using Bazett (QT/RR(0.5)), Fridericia (QT/RR(0.33)), Framingham [QT + 0.154 * (1000 - RR)], and Hodges (QT + 105 * (1/ @entity8 )) formulas. RESULTS: In 6723 @entity0 with a median follow-up of 4.5 years (interquartile range 1.9-6.4 years), the annualized cardiovascular event rate was 2.3% and the annualized mortality rate was 2.2%. QT prolongation was diagnosed in 39% of the cohort using the Bazett formula, 6.2% using the Fridericia formula, 3.7% using the Framingham formula, and 8.7% using the Hodges formula. Only the Hodges formula was an independent risk marker for @entity2 across the range of QT values (highest tertile: hazard ratio 1.26; 95% confidence interval 1.03-1.55). CONCLUSION: Although all correction formulas demonstrated an association between QTc values and cardiovascular events, only the Hodges formula identified one-third of individuals with @entity4 that are at higher risk of all-cause mortality. Furthermore, the Bazett correction formula overestimates the number of @entity0 with a prolonged QT interval and was not associated with mortality. Future work may validate these findings and result in changes to automated algorithms for QT interval assessment.

title: Optimal @entity7 formula in @entity9 for identifying cardiovascular and mortality risk: Findings from the Penn XXXX Free study.

answer: @entity6


abstract: BACKGROUND: The QT interval measures cardiac repolarization, and prolongation is associated with adverse cardiovascular outcomes and @entity2 . The exponential Bazett correction formula overestimates the QT interval during @entity4 . OBJECTIVE: We evaluated 4 formulas of @entity7 in individuals with @entity9 for the identification of @entity3 , @entity5 , and mortality. METHODS: The Penn @entity6 Free study is a large cohort study of @entity0 without @entity6 . The present study examined 6723 Penn @entity6 Free study @entity0 without a history of @entity5 and with baseline @entity1 rate >= 100 beats/min. Medical records were queried for index clinical parameters, incident cardiovascular events, and all-cause mortality. The QT interval was corrected by using Bazett (QT/RR(0.5)), Fridericia (QT/RR(0.33)), Framingham [QT + 0.154 * (1000 - RR)], and Hodges (QT + 105 * (1/ @entity8 )) formulas. RESULTS: In 6723 @entity0 with a median follow-up of 4.5 years (interquartile range 1.9-6.4 years), the annualized cardiovascular event rate was 2.3% and the annualized mortality rate was 2.2%. QT prolongation was diagnosed in 39% of the cohort using the Bazett formula, 6.2% using the Fridericia formula, 3.7% using the Framingham formula, and 8.7% using the Hodges formula. Only the Hodges formula was an independent risk marker for @entity2 across the range of QT values (highest tertile: hazard ratio 1.26; 95% confidence interval 1.03-1.55). CONCLUSION: Although all correction formulas demonstrated an association between QTc values and cardiovascular events, only the Hodges formula identified one-third of individuals with @entity4 that are at higher risk of all-cause mortality. Furthermore, the Bazett correction formula overestimates the number of @entity0 with a prolonged QT interval and was not associated with mortality. Future work may validate these findings and result in changes to automated algorithms for QT interval assessment.

title: Optimal XXXX formula in @entity9 for identifying cardiovascular and mortality risk: Findings from the Penn @entity6 Free study.

answer: @entity7


abstract: PURPOSE: @entity3 ( @entity3 ) may likely influence recanalization after thrombolysis. We assessed, through the European sequential MRI database "I-KNOW," the relationship between the presence of @entity3 on T2-weighted gradient echo imaging, its angiographic counterpart on magnetic resonance angiography and its subsequent impact on recanalization after thrombolysis. MATERIALS AND METHODS: Initial clinical and MRI characteristics and early follow up were analyzed in acute @entity1 @entity2 @entity0 treated with rt-Pa within 4.5 hours. @entity0 underwent multimodal MRI at admission. Sequential imaging performed 3 hours, 2 days and 1 month later allowed the analysis of @entity3 changes and recanalization. RESULTS: Fifty @entity0 were included in the study. @entity3 was observed in 54% of cases at admission. @entity3 was still present in 46% @entity0 at 3 hours, 16% at 2 days, and 0% at 1 month. It was an independent predictor of no recanalization after thrombolysis (P = .04). After 3 hours, @entity3 disappeared in only 4 cases, and was not linked with recanalization on MRA. Conversely, when @entity3 persisted, a partial or complete recanalization was observed in 9 and 6 cases, respectively. CONCLUSIONS: @entity3 is a predictor of lower recanalization rate. Its disappearance is not necessarily correlated with recanalization.

title: Sequential MR Assessment of the Susceptibility Vessel Sign and Arterial Occlusion in Acute XXXX .

answer: @entity2


abstract: PURPOSE: Enhanced S Cone Syndrome is a rare @entity0 characterized clinically by an absence of rod function, a replacement of most L and M cone function by S cone activity ( @entity4 ) and by variable degrees of @entity3 in different families. The causative gene, @entity5 ( @entity5 ), controls the developmental sequence for rods and cones. The purpose of this study was to compare the nature and implications of mutations in two subjects with Enhanced S Cone Syndrome who have significantly different degrees of @entity1 . METHODS: A direct sequencing approach was used to identify the mutations. Genomic DNA was amplified from all the exons of @entity5 and used as a template for sequencing. Of the two families studied, Case 1 is of Persian ethnicity while Case 2 is Brazilian. A total of six individuals within the two families were studied. RESULTS: Case 1 (original propositus of the syndrome) has the characteristic developmental rod/cone abnormality with large amplitude electroretinogram responses and no @entity3 . She was homozygous for a novel mutation, @entity6 ( @entity7 ), which lies entirely within the P-box for this gene. By comparison, Case 2 had @entity4 with @entity3 and low electroretinogram signals. She was a compound heterozygote for @entity8 ( @entity9 ), mutations that have been reported previously. Her second mutation overlaps that of Case 1 within the P-box. CONCLUSIONS: The novel in-frame homozygous deletion of Case 1, within the P-box motif of the DNA binding domain, caused a @entity2 without @entity3 . Case 2, with more traditional @entity4 with @entity3 , was a compound heterozygote where one allele had a similar P-box deletion but the other was a splicing defect. Case 1 is the first reported homozygous deletion within the P-box. This is the first report of @entity5 mutations in a Persian and a Brazilian family.

title: Developmental or degenerative-- XXXX gene mutations in two patients with enhanced S cone syndrome.

answer: @entity5


abstract: BACKGROUND: Nowadays, the collection of PBPCs by apheresis from healthy donors is a routine method. The mobilization with rHu @entity4 and the apheresis procedures are usually well tolerated without severe side effects. STUDY DESIGN AND METHODS: We report a severe complication in a 41-year-old unrelated female donor who was allowed to donate PBPCs and was mobilized with 10 microg of @entity4 per kg per day. During PBPC apheresis, she experienced a @entity3 after 132 minutes and processing of 7078 mL of blood (twice the donor's blood volume). RESULTS: Immediate cardiopulmonary resuscitation restored sinus rhythm and regulatory respiration without sequelae. Subsequent cardiologic examinations (heart catheterization, electrophysiologic testing, tilting table test) resulted in the diagnosis of a @entity2 . Other @entity1 could be excluded. The implantation of a cardiac pacemaker was recommended to the donor. The 4-year-old recipient was successfully transplanted with the partial product collected until the arrest occurred. The @entity0 received a total of 2.54 x 106 @entity5 + cells per kg of body weight. CONCLUSION: After exclusion of other @entity1 , the diagnosed @entity2 probably induced the @entity3 during apheresis rather than the administration of @entity4 .

title: XXXX during PBPC apheresis in an unrelated donor.

answer: @entity3


abstract: PURPOSE: Treatment of the posterior @entity4 mandible has long been a challenge in implant dentistry and maxillofacial surgery. The objective of this study was to reevaluate the safety and efficacy of the sandwich osteotomy and bone grafting in @entity0 with moderate to severe posterior mandibular @entity1 . MATERIALS AND METHODS: This retrospective study included @entity0 with an edentulous posterior mandible in which there was not enough bone above the dental nerve to insert implants at least 10 mm in length; @entity0 with adequate bone volume but with an excessive interocclusal distance at the posterior occlusal region were also included. Twenty-three @entity0 with 30 sites of moderate to severe posterior @entity1 were treated using a sandwich osteotomy above the mental nerve and an interpositioned block of autologous or allogeneic bone. Success criteria were based on the possibility of implant insertion after bone grafting. RESULTS: The average gain in height was 5.3 mm (range, 2 to 10 mm). Partial @entity3 was observed in only one @entity0 from the allogeneic graft group. @entity0 were followed for 12 to 93 months after bone grafting. No signs of @entity2 were observed. Minor dehiscence of the surgical wound occurred in four segments, but healing ultimately occurred in every @entity0 . Sixty-five implants were placed, and none were lost during follow-up. Insertion of implants of 10 mm or more in length was successfully achieved in 90.8% of the sites, and partial success (ie, bone segments suitable for insertion of shorter implants) was seen in the remaining sites. CONCLUSIONS: Moderate to severe posterior mandibular @entity1 can be successfully treated by interpositional sandwich osteotomy and bone grafting, allowing for the subsequent placement of implants and fixed prostheses in all segments.

title: Implant rehabilitation of the edentulous posterior XXXX mandible: the sandwich osteotomy revisited.

answer: @entity4


abstract: OBJECTIVE: To study @entity2 ( @entity2 ) with concurrent @entity5 ( @entity5 ) in regions of high altitude. METHODS: 18,090 inpatients from Feb. 1956 to Dec. 1995 conforming to a screening standard were observed in a hospital located at altitude 3658 m. 1,028 inpatients suffering from @entity2 when hospitalized were collected as a study group. 17,020 inpatients suffering from non-HAD when first hospitalized served as a control group. The morbidity rate of @entity5 in these two groups in a follow-up period of 1 - 20 years was analyzed. RESULTS: (1) @entity5 morbidity rate was increasing with prolongation of observation time in the control group, but it was not so in the study group. Annual and accumulative morbidity of @entity5 in the study group was obviously higher than that in the control group (P < 0.005, OR = 5.03, RR = 4.33). (2) The morbidity rates of three types of @entity5 aside from @entity7 ( @entity7 ) of @entity1 ( @entity1 ) group and @entity6 ( @entity6 ) of @entity4 ( @entity4 ) group was obviously higher in the study group than in the control (P < 0.05 - 0.005). @entity5 morbidity rate in @entity4 group and @entity3 was 23.5% and 22.0% (OR = 7.33 - 6.71, RR = 5.86 - 5.47). (3) @entity5 morbidity rate in @entity4 group and @entity3 group was obviously higher than that in the control, constituting mainly a high morbidity of mild @entity5 . CONCLUSION: The risk of @entity5 increases about 5-fold in @entity2 @entity0 than in the multitude of high altitude acclimatization, being most evident in @entity4 and @entity3 .

title: [A retrospective clinical study of XXXX complicated by acute exacerbation in high altitude environment].

answer: @entity2


abstract: @entity2 ( @entity2 ) @entity3 and @entity3 rates are putative clinical markers of progression to @entity4 ( @entity4 ). We compared results given by two different automated @entity2 segmentation techniques in the @entity4 Neuroimaging Initiative dataset between two time intervals. We used @entity2 volumetric automated segmentation data for a total of 683 @entity0 at baseline (198 controls, 331 with @entity1 ( @entity1 ) and 154 with @entity4 ), 684 at 6 months (198 controls, 332 with @entity1 and 154 with @entity4 ) and 587 at 12 months (176 controls, 280 with @entity1 and 131 with @entity4 ). Segmentation techniques included FreeSurfer and @entity5 . We calculated @entity2 monthly @entity3 rates between baseline and 6 months and between 6 and 12 months, and used a multiple-way ANOVA for repeated measures. Mean @entity2 volumes decrease with time. The only significant (p<0.05) main effect was diagnosis. We measured strong interaction between technique and scan interval and weak interaction between diagnoses and scan interval. When compared to mean rates from largely manual segmentation, automated segmentation results show increased @entity3 rates for both @entity5 and FreeSurfer techniques. While sensitive, there remains substantial technique variability, likely due to differences in methodological approaches and especially @entity2 . These fundamental metrological problems need to be resolved before concluding with certainty on the accuracy and reliability of automated techniques.

title: XXXX rates in @entity4 : automated segmentation variability analysis.

answer: @entity3


abstract: @entity2 ( @entity2 ) @entity3 and @entity3 rates are putative clinical markers of progression to @entity4 ( @entity4 ). We compared results given by two different automated @entity2 segmentation techniques in the @entity4 Neuroimaging Initiative dataset between two time intervals. We used @entity2 volumetric automated segmentation data for a total of 683 @entity0 at baseline (198 controls, 331 with @entity1 ( @entity1 ) and 154 with @entity4 ), 684 at 6 months (198 controls, 332 with @entity1 and 154 with @entity4 ) and 587 at 12 months (176 controls, 280 with @entity1 and 131 with @entity4 ). Segmentation techniques included FreeSurfer and @entity5 . We calculated @entity2 monthly @entity3 rates between baseline and 6 months and between 6 and 12 months, and used a multiple-way ANOVA for repeated measures. Mean @entity2 volumes decrease with time. The only significant (p<0.05) main effect was diagnosis. We measured strong interaction between technique and scan interval and weak interaction between diagnoses and scan interval. When compared to mean rates from largely manual segmentation, automated segmentation results show increased @entity3 rates for both @entity5 and FreeSurfer techniques. While sensitive, there remains substantial technique variability, likely due to differences in methodological approaches and especially @entity2 . These fundamental metrological problems need to be resolved before concluding with certainty on the accuracy and reliability of automated techniques.

title: @entity3 rates in XXXX : automated segmentation variability analysis.

answer: @entity4


abstract: This essay contrasts the responses of @entity0 with @entity1 described by Kaufman with the reflections of @entity0 with @entity3 ( @entity3 ). It is suggested that, over the last decade or so, mainstream medicine has become less reductionist and more humane in focus. Many with @entity3 become reconciled to their new bodies, though this may take years. It is not clear whether this apparent difference in the responses of those with @entity1 , related by Kaufman, reflects their older age or other factors. Perhaps it takes longer than 2 to 3 years for some @entity0 to become reconciled to profound alterations in their embodiment. Medical and social models of impairment are discussed. The effects of personal reductions in function may be lessened in significance through appropriate environmental adaptations and changes in social attitudes. In agreement with Kaufman, the importance of an effective personal assistant/employer relationship is illustrated in relation to those with @entity4 . Overall the perspective of @entity0 with @entity3 is not as pessimistic as that of those with @entity1 , as related by Kaufman. However, her plea for a deeper and richer exploration of the lived experience of @entity2 is supported for many reasons.

title: Pathways to the reconstruction of selfhood in chronic transformative disability: the example of XXXX .

answer: @entity3


abstract: BACKGROUND: This study examined the relationship between emotional distress as measured by the @entity3 ( @entity3 ) and the Fertility Quality of Life (FertiQoL) questionnaire. METHODS: The FertiQoL and @entity3 were distributed to a random sample of 785 @entity0 attending 29 Dutch clinics for medically assisted reproduction. FertiQoL was psychometrically tested for reliability. Pearson's correlations were calculated between subscales of FertiQoL and @entity3 . Using an independent t-test, differences between @entity0 subgroups were computed for both instruments. The threshold for clinically meaningful @entity3 / @entity1 on the @entity3 subscales was used to ascertain the critical threshold for high distress on the FertiQoL scales. RESULTS: FertiQoL and @entity3 were completed by 583 @entity0 (response 74%). Reliability of FertiQoL scales was high (reliability coefficient between 0.72 and 0.91). Significant negative correlations were found between FertiQoL subscales and @entity3 scores for @entity1 and @entity3 , ranging from -0.29 to -0.71. Means on FertiQoL scales and @entity3 scales of couples undergoing an assisted reproductive technology (ART) treatment and a non-ART treatment did not differ significantly. @entity0 scoring above the @entity3 threshold for pathology on @entity1 had an average FertiQoL score of 58.8, whereas @entity0 exceeding the @entity3 @entity3 threshold had a FertiQoL total score of 51.9 (range 0-100). CONCLUSIONS: Our study confirms the expected negative relation between quality of life as measured by FertiQoL and @entity1 and @entity3 . The data support that FertiQoL reliably measures QoL in @entity0 facing @entity2 . FertiQoL enables clinicians to tailor care more specifically to the @entity0 in a comprehensive way.

title: Relationship between quality of life and distress in XXXX : a validation study of the Dutch FertiQoL.

answer: @entity2


abstract: OBJECTIVES: Head-to-head comparison of ultrasound and CT accuracy in common diagnoses causing acute @entity1 . MATERIALS AND METHODS: Consecutive @entity0 with @entity1 for >2 h and <5 days referred for imaging underwent both US and CT by different radiologists/radiological residents. An expert panel assigned a final diagnosis. Ultrasound and CT sensitivity and predictive values were calculated for frequent final diagnoses. Effect of @entity0 characteristics and observer experience on ultrasound sensitivity was studied. RESULTS: Frequent final diagnoses in the 1,021 @entity0 (mean age 47; 55% female) were @entity2 (284; 28%), @entity4 (118; 12%) and @entity3 (52; 5%). The sensitivity of CT in detecting @entity2 and @entity4 was significantly higher than that of ultrasound: 94% versus 76% (p   <   0.01) and 81% versus 61% (p   =   0.048), respectively. For @entity3 , the sensitivity of both was 73% (p   =   1.00). Positive predictive values did not differ significantly between ultrasound and CT for these conditions. Ultrasound sensitivity in detecting @entity2 and @entity4 was not significantly negatively affected by @entity0 characteristics or reader experience. CONCLUSION: CT misses fewer cases than ultrasound, but both ultrasound and CT can reliably detect common diagnoses causing acute @entity1 . Ultrasound sensitivity was largely not influenced by @entity0 characteristics and reader experience.

title: A comparison of the accuracy of ultrasound and computed tomography in common diagnoses causing acute XXXX .

answer: @entity1


abstract: @entity12 have been proposed to act as chemopreventive agents in numerous epidemiological studies and have been shown to inhibit angiogenesis and proliferation of @entity1 cells and endothelial cells in vitro. Angiogenesis requires tightly controlled extracellular matrix degradation mediated by extracellular proteolytic enzymes including matrix metalloproteinases (MMPs) and @entity4 proteases, in particular, the urokinase-type plasminogen activator ( @entity10 )-plasmin system. In this study, we have investigated the antiangiogenic mechanism of the @entity12 , @entity5 , @entity14 , and @entity16 in a @entity0 umbilical vein endothelial cell (HUVEC) model. The stimulation of serum-starved HUVECs with vascular endothelial growth factor/basic fibroblast growth factor ( @entity17 ) caused marked increase in @entity13 production and induced the pro- @entity6 activation accompanied by the increase in @entity7 expression. However, pretreatment with @entity12 before @entity2 / @entity3 stimulation completely abolished the @entity2 / @entity3 -stimulated increase in @entity13 and @entity7 expression and pro- @entity6 activation. @entity5 blocked @entity2 / @entity3 -stimulated increase in @entity11 expression and decrease in @entity8 expression. @entity14 and @entity16 further decreased @entity11 expression below basal level and completely abolished @entity8 expression. @entity2 and @entity3 stimulation also significantly induced @entity10 expression, most strikingly the level of 33 kDa @entity10 , and increased the expression of @entity9 . @entity5 , @entity14 , and @entity16 effectively blocked the generation of 33 kDa @entity10 , and further decreased the activity of the 55 kDa @entity10 and the expression of @entity9 below the basal level. In conclusion, these data suggest that @entity5 , @entity14 , and @entity16 inhibit in vitro angiogenesis, in part via preventing @entity2 / @entity3 -induced @entity13 and @entity10 expression and the activation of pro- @entity6 , and via modulating their inhibitors, @entity15 , and @entity9 .

title: @entity12 inhibit XXXX / @entity3 -induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.

answer: @entity2


abstract: @entity12 have been proposed to act as chemopreventive agents in numerous epidemiological studies and have been shown to inhibit angiogenesis and proliferation of @entity1 cells and endothelial cells in vitro. Angiogenesis requires tightly controlled extracellular matrix degradation mediated by extracellular proteolytic enzymes including matrix metalloproteinases (MMPs) and @entity4 proteases, in particular, the urokinase-type plasminogen activator ( @entity10 )-plasmin system. In this study, we have investigated the antiangiogenic mechanism of the @entity12 , @entity5 , @entity14 , and @entity16 in a @entity0 umbilical vein endothelial cell (HUVEC) model. The stimulation of serum-starved HUVECs with vascular endothelial growth factor/basic fibroblast growth factor ( @entity17 ) caused marked increase in @entity13 production and induced the pro- @entity6 activation accompanied by the increase in @entity7 expression. However, pretreatment with @entity12 before @entity2 / @entity3 stimulation completely abolished the @entity2 / @entity3 -stimulated increase in @entity13 and @entity7 expression and pro- @entity6 activation. @entity5 blocked @entity2 / @entity3 -stimulated increase in @entity11 expression and decrease in @entity8 expression. @entity14 and @entity16 further decreased @entity11 expression below basal level and completely abolished @entity8 expression. @entity2 and @entity3 stimulation also significantly induced @entity10 expression, most strikingly the level of 33 kDa @entity10 , and increased the expression of @entity9 . @entity5 , @entity14 , and @entity16 effectively blocked the generation of 33 kDa @entity10 , and further decreased the activity of the 55 kDa @entity10 and the expression of @entity9 below the basal level. In conclusion, these data suggest that @entity5 , @entity14 , and @entity16 inhibit in vitro angiogenesis, in part via preventing @entity2 / @entity3 -induced @entity13 and @entity10 expression and the activation of pro- @entity6 , and via modulating their inhibitors, @entity15 , and @entity9 .

title: XXXX inhibit @entity2 / @entity3 -induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.

answer: @entity12


abstract: @entity12 have been proposed to act as chemopreventive agents in numerous epidemiological studies and have been shown to inhibit angiogenesis and proliferation of @entity1 cells and endothelial cells in vitro. Angiogenesis requires tightly controlled extracellular matrix degradation mediated by extracellular proteolytic enzymes including matrix metalloproteinases (MMPs) and @entity4 proteases, in particular, the urokinase-type plasminogen activator ( @entity10 )-plasmin system. In this study, we have investigated the antiangiogenic mechanism of the @entity12 , @entity5 , @entity14 , and @entity16 in a @entity0 umbilical vein endothelial cell (HUVEC) model. The stimulation of serum-starved HUVECs with vascular endothelial growth factor/basic fibroblast growth factor ( @entity17 ) caused marked increase in @entity13 production and induced the pro- @entity6 activation accompanied by the increase in @entity7 expression. However, pretreatment with @entity12 before @entity2 / @entity3 stimulation completely abolished the @entity2 / @entity3 -stimulated increase in @entity13 and @entity7 expression and pro- @entity6 activation. @entity5 blocked @entity2 / @entity3 -stimulated increase in @entity11 expression and decrease in @entity8 expression. @entity14 and @entity16 further decreased @entity11 expression below basal level and completely abolished @entity8 expression. @entity2 and @entity3 stimulation also significantly induced @entity10 expression, most strikingly the level of 33 kDa @entity10 , and increased the expression of @entity9 . @entity5 , @entity14 , and @entity16 effectively blocked the generation of 33 kDa @entity10 , and further decreased the activity of the 55 kDa @entity10 and the expression of @entity9 below the basal level. In conclusion, these data suggest that @entity5 , @entity14 , and @entity16 inhibit in vitro angiogenesis, in part via preventing @entity2 / @entity3 -induced @entity13 and @entity10 expression and the activation of pro- @entity6 , and via modulating their inhibitors, @entity15 , and @entity9 .

title: @entity12 inhibit @entity2 / XXXX -induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.

answer: @entity3


abstract: OBJECTIVE: The @entity0 with @entity1 after the radiation, chemical and operative therapies were often not able to get effective treatment because their lesions involved in the nervous and vascular structure and the re-radiation therapy was not suitable or chemical therapy was not sensitive to the @entity1 as well. To improve their survival quality, prevent the fatal complication and prolong their life, the surgical treatment for them was advised. METHOD: Six @entity0 were treated surgically. According to the lesion of extension and position, the different incisions were respectively made. The @entity1 of these @entity0 were resected piece by piece because they usually involved in the important structures, such as the internal carotid artery and cavernous sinus. Then, local defect was repaired with different methods on basis of the individual condition. So, this type of operation could be called as non-defined operation. RESULTS: The lesions in all 6 @entity0 invaded the eye, meninges and encephala, skull base, cavernous sinus and other important structures. After surgical intervene, the @entity0 were all more than one year survival except for one of the @entity0 who died of serous bleeding with @entity3 . Three @entity0 survived for 4, 5 and 12 years, respectively. CONCLUSION: The craniofacial recurrent @entity2 in late stage could be resected by the non-defined operation, which could prolong the @entity0 life and achieve the desired effect.

title: [Surgical treatment of XXXX ].

answer: @entity2


abstract: BACKGROUND: Few studies have suggested that routine bone marrow (BM) and cerebrospinal fluid (CSF) evaluation is not needed in all @entity0 with @entity2 . Although the International @entity2 Staging System was developed recently, there remain no clear stage-specific guidelines with regard to the need for BM and CSF evaluations as part of the metastatic workup for @entity0 with @entity2 . METHODS: This is a retrospective study analyzing results of CSF cytology and BM evaluation at presentation/diagnosis in @entity0 with @entity2 registered at our center from June, 2003 to June, 2009. Only cases with both BM biopsy and lumbar puncture were included. RESULTS: Of the 259 evaluable @entity0 , 18 (7%) were positive for @entity1 either in CSF and/or BM. Although 7 of these had overt @entity1 at presentation (stage IV), 1 belonged to stage II and 10 to stage IIIa. No stage 0 or I @entity0 tested positive despite presence of histopathologic high-risk factors. CONCLUSIONS: This is the largest study evaluating the role of metastatic workup in @entity0 with @entity2 at presentation. We conclude that CSF and BM evaluation is not required in @entity0 with stage 0 and I @entity2 at presentation. No definitive recommendation could be made for stage II @entity0 ; while stage III and IV @entity0 must certainly be evaluated.

title: Bone marrow aspirations and lumbar punctures in XXXX at diagnosis: correlation with IRSS staging.

answer: @entity2


abstract: PURPOSE: To study the efficacy of reirradiation as salvage treatment in @entity0 with locally recurrent @entity4 . @entity0 AND METHODS: Between 1993 and 2000, 20 consecutive @entity0 (twelve males and eight females) with @entity1 , previously irradiated in different Hungarian institutions, were reirradiated for biopsy-proven locally recurrent @entity1 . Histologically, 85% of the @entity0 had WHO type III, 5% type II, and 10% type I disease. Stages I-IV (AJCC 1997 staging system) were assigned to five (25%), seven (35%), five (25%), and three (15%) @entity0 , respectively; none of them had distant metastases, and only eight (40%) displayed regional dissemination. The median time period between termination of primary treatment and local recurrence was 30 (range, 10-204) months. Brachytherapy was the method most frequently used: in ten cases alone (especially for rT1 @entity1 ), and in eight cases in combination with external beam therapy. Two @entity0 with locally advanced disease underwent external beam therapy only. The median dose in the event of brachytherapy alone was 20 Gy (4 x 5 Gy or 5 x 4 Gy, range, 16-36 Gy), and the dose range for exclusive external irradiation was 30-40 Gy. In cases of combined irradiation, a median 20-Gy brachytherapy (range, 16-40 Gy) was associated with 30-40 Gy of external irradiation. Radiotherapy was supplemented by neck dissection (six @entity0 ), nasopharyngectomy (one @entity0 ), or chemotherapy (eleven @entity0 ). RESULTS: 16 @entity0 were reirradiated once, three twice, and one @entity0 three times, with a median equivalent dose for @entity1 effect of 36 Gy (mean, 44 Gy; range, 19-117 Gy; the estimated alpha/beta-ratio was 10 Gy). The median equivalent dose of reirradiation for late effect on normal tissue (with an estimated 70% delivery of the @entity1 dose) amounted to 30 Gy (mean, 37 Gy; range, 13-101 Gy, estimated alpha/beta-ratio 3 Gy). After a median follow-up of 37 (range, 12-72) months, the overall survival was 60% (12/20). Seven of the twelve surviving @entity0 are currently @entity1 -free. After primary irradiation, xerostomy occurred in all @entity0 as an unavoidable side effect of treatment. Following reirradiation, a severe (grade 3 or higher) late @entity3 (CTC criteria, version 2) has been observed in two @entity1 -free @entity0 (10%) so far ( @entity2 of soft palate and paresis of glossopharyngeal nerve). CONCLUSION: Retreatment of @entity4 with radiotherapy (preferably a combined modality), can result in longterm local control and survival in a substantial proportion of @entity0 , at the price of an acceptable morbidity.

title: Reirradiation of locally recurrent XXXX .

answer: @entity4


abstract: BACKGROUND: Survival data of @entity3 ( @entity3 ) registered in SIOP trials, advocating preoperative chemotherapy, are not available. AIM: To evaluate characteristics, response and survival of @entity3 @entity0 registered in recent SIOP protocols. METHODS: An evaluation of all @entity3 @entity0 treated from 1993 to 2005 (SIOP trials 93-01 and 2001) was performed. Data were obtained from study specific case record forms and entered centrally in a database. RESULTS: Hundred and seven @entity0 were identified (57 male), with a median age at diagnosis of 13 months (interquartile range 6-27 months), and a median follow-up time of 60 months. Left and right kidneys were equally affected. @entity1 stage distribution was stage I (6%), stage II (22%), stage III (43%), stage IV (22%) and stage V (3%). Stage IV @entity0 included 17 with @entity2 (8 lung-only) and 12 with multiple organ metastases (bone, brain and liver). Primary surgery was the upfront treatment approach in 22/107 @entity0 (21%), by which 19 @entity0 reached a complete remission (CR). Median difference in @entity1 volume before and after preoperative chemotherapy was 69 ml (interquartile range: 4.5-158.0, P < 0.0001), indicating marked chemosensitivity. The 5-year event-free survival (EFS) of the total group was 22% (95% CI: 15-33) and overall survival 26% (95% CI: 18-37). Most events (86%) occurred within the first 2 years after diagnosis. Younger age at diagnosis was an important adverse prognostic factors for survival. In contrast, @entity1 volume at diagnosis, nor volume reduction was associated with outcome. CONCLUSION: @entity3 has a poor outcome especially in young and advanced-stage disease @entity0 . Neither @entity1 volume at diagnosis, nor pre-operative chemosensitivity are prognostic factors for survival.

title: @entity1 of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the XXXX study group.

answer: @entity3


abstract: BACKGROUND: Survival data of @entity3 ( @entity3 ) registered in SIOP trials, advocating preoperative chemotherapy, are not available. AIM: To evaluate characteristics, response and survival of @entity3 @entity0 registered in recent SIOP protocols. METHODS: An evaluation of all @entity3 @entity0 treated from 1993 to 2005 (SIOP trials 93-01 and 2001) was performed. Data were obtained from study specific case record forms and entered centrally in a database. RESULTS: Hundred and seven @entity0 were identified (57 male), with a median age at diagnosis of 13 months (interquartile range 6-27 months), and a median follow-up time of 60 months. Left and right kidneys were equally affected. @entity1 stage distribution was stage I (6%), stage II (22%), stage III (43%), stage IV (22%) and stage V (3%). Stage IV @entity0 included 17 with @entity2 (8 lung-only) and 12 with multiple organ metastases (bone, brain and liver). Primary surgery was the upfront treatment approach in 22/107 @entity0 (21%), by which 19 @entity0 reached a complete remission (CR). Median difference in @entity1 volume before and after preoperative chemotherapy was 69 ml (interquartile range: 4.5-158.0, P < 0.0001), indicating marked chemosensitivity. The 5-year event-free survival (EFS) of the total group was 22% (95% CI: 15-33) and overall survival 26% (95% CI: 18-37). Most events (86%) occurred within the first 2 years after diagnosis. Younger age at diagnosis was an important adverse prognostic factors for survival. In contrast, @entity1 volume at diagnosis, nor volume reduction was associated with outcome. CONCLUSION: @entity3 has a poor outcome especially in young and advanced-stage disease @entity0 . Neither @entity1 volume at diagnosis, nor pre-operative chemosensitivity are prognostic factors for survival.

title: XXXX of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the @entity3 study group.

answer: @entity1


abstract: In order to further improve and explore the role of lasers for nerve reconstruction, this study was designed to investigate regeneration of sharply transected peripheral nerves repaired with a @entity2 milliwatt laser in combination with three different suture materials and a @entity1 albumin protein solder as an adjunct to the welding process. Unilateral sciatic nerve repair was performed in 44 @entity0 . In the laser group, nerves were gently apposed, and two stay sutures (10-0 nylon, 10-0 @entity4 , or 25 microm stainless steel) were placed epi/perineurially. Thereafter, the repair site was fused at 100 mW with pulses of 1.0 s. In the subgroup of laser-assisted nerve repair (LANR), albumen was used as a soldering agent to further reinforce the repair site. The control group consisted of nerves repaired by conventional microsurgical suture repair (CMSR), using 4-6 10-0 nylon sutures. Evaluation was performed at 1 and 6 weeks after surgery, and included qualitative and semiquantitative light microscopy. LANR performed with a protein solder results in a good early peripheral nerve regeneration, with an optimal alignment of nerve fibers and minimal connective tissue proliferation at the repair site. All three suture materials produced a foreign body reaction; the least severe was with @entity4 sutures. CMSR resulted in more pronounced @entity3 at the repair site, with more connective-tissue proliferation and axonal misalignment. Furthermore, axonal regeneration in the distal nerve segment was better in the laser groups. Based on these results, @entity2 laser-assisted nerve repair with soldering in combination with absorbable sutures has the potential of allowing healing to occur with the least foreign-body reaction at the repair site. Further experiments using this combination are in progress.

title: Carbon dioxide laser-assisted nerve repair: effect of solder and suture material on nerve regeneration in XXXX sciatic nerve.

answer: @entity0


abstract: OBJECTIVES: @entity5 laser-assisted endoscopic cricopharyngeal myotomy (ECPM) has emerged as a viable therapy for @entity6 . The risks of the procedure include pharyngoesophageal perforation and @entity7 , which may discourage adoption of this technique. To address these complications, we examined outcomes of ECPM with primary mucosal closure. METHODS: A case series of 7 @entity0 who underwent ECPM between 2006 and 2008 were reviewed for length of operation, length of hospitalization, @entity3 , and outcomes by use of the M. D. Anderson @entity6 Index (MDADI) and the Functional Outcome Swallowing Scale (FOSS). The results were compared to those of a control group of 7 @entity0 treated during the same period via open cricopharyngeal myotomy. RESULTS: All @entity0 who had ECPM were treated successfully without complications. The operative times averaged 128 minutes. The hospitalization averaged 2.1 days. Statistically significant improvements in swallowing were seen (MDADI score from 51.3 to 77.7, p < 0.0006; FOSS score from 3.7 to 1.3, p < 0.0005), and were similar to those in the @entity0 who had the open procedure (FOSS score from 3.0 to 1.0, p <0.006). Trends toward decreased @entity2 , a shorter hospital stay, and a lower complication rate were observed in the @entity0 who had ECPM. CONCLUSIONS: ECPM is beneficial as a primary treatment for @entity4 . Closure of the @entity1 may help reduce the incidence of postoperative cervical @entity8 and @entity7 , and does not appear to compromise functional outcome.

title: XXXX laser-assisted endoscopic cricopharyngeal myotomy with primary mucosal closure.

answer: @entity5


abstract: A comparative study of right ventricular histopathologic findings and clinical profiles in 174 cases with @entity4 ( @entity4 ), 145 cases with @entity2 ( @entity2 ), and 241 cases with idiopathic @entity3 and/or conduction disturbance with significant myocardial pathology [Electric disturbance type of @entity0 ( @entity8 )], totaling 560 cases, was made in order to clarify the role of @entity7 in these conditions. @entity6 ( @entity6 ) was defined by assessing serial biopsy findings in nine cases with @entity7 . The @entity6 was observed in three cases with @entity4 (1.7%), 22 with @entity2 (15%), and 21 with @entity8 (8.7%). The incidence of @entity6 was significantly higher in @entity2 and @entity8 than in @entity4 (P less than 0.001). The typical pattern of onset of @entity7 , i.e., high fever, @entity5 , and gastrointestinal symptoms preceding @entity1 within 10 days, was recognized in one case with @entity4 , eight with @entity2 , and 6 of 123 cases with @entity8 . The incidence was higher in @entity2 and @entity8 than in @entity4 (P less than 0.05). Of 46 cases with @entity6 , 12 (26%) showed this pattern, on the other hand only 3 of 377 cases (0.8%) without @entity6 did so (P less than 0.0001). Familial occurrence was not found in any of the 46 cases with @entity6 but was found in 38 of the 377 cases without @entity6 (P less than 0.01). This study indicates that @entity7 may often be the causative agent of @entity0 , especially @entity2 and @entity8 . It is also noticed that familial occurrence of the cases with @entity6 was never seen.

title: A clinicopathologic study on a cause of XXXX and @entity3 and conduction disturbance employing endomyocardial biopsy.

answer: @entity0


abstract: A comparative study of right ventricular histopathologic findings and clinical profiles in 174 cases with @entity4 ( @entity4 ), 145 cases with @entity2 ( @entity2 ), and 241 cases with idiopathic @entity3 and/or conduction disturbance with significant myocardial pathology [Electric disturbance type of @entity0 ( @entity8 )], totaling 560 cases, was made in order to clarify the role of @entity7 in these conditions. @entity6 ( @entity6 ) was defined by assessing serial biopsy findings in nine cases with @entity7 . The @entity6 was observed in three cases with @entity4 (1.7%), 22 with @entity2 (15%), and 21 with @entity8 (8.7%). The incidence of @entity6 was significantly higher in @entity2 and @entity8 than in @entity4 (P less than 0.001). The typical pattern of onset of @entity7 , i.e., high fever, @entity5 , and gastrointestinal symptoms preceding @entity1 within 10 days, was recognized in one case with @entity4 , eight with @entity2 , and 6 of 123 cases with @entity8 . The incidence was higher in @entity2 and @entity8 than in @entity4 (P less than 0.05). Of 46 cases with @entity6 , 12 (26%) showed this pattern, on the other hand only 3 of 377 cases (0.8%) without @entity6 did so (P less than 0.0001). Familial occurrence was not found in any of the 46 cases with @entity6 but was found in 38 of the 377 cases without @entity6 (P less than 0.01). This study indicates that @entity7 may often be the causative agent of @entity0 , especially @entity2 and @entity8 . It is also noticed that familial occurrence of the cases with @entity6 was never seen.

title: A clinicopathologic study on a cause of @entity0 and XXXX and conduction disturbance employing endomyocardial biopsy.

answer: @entity3


abstract: BACKGROUND: Recent studies have reported the association of gamma-glutamyltransferase ( @entity12 ) or ferritin with @entity2 . However, there has been no large population-based study assessing the interrelationship of these two biomarkers and their association with @entity7 resistance. METHODS: A population-based cross-sectional study was carried out in the Chinese Liangshan Yi ethnic group. 756 eligible subjects, aged 20 - 74 years, were included. Demographic characteristics, medical history, and lifestyle data were collected through questionnaires. An oral @entity4 tolerance test was performed. Laboratory tests, including @entity12 and ferritin measurements, were conducted. Spearman's rank-order correlation and multiple linear regression were used to calculate the correlation of @entity12 with ferritin and their relationship to the @entity7 resistance index determined by the homeostasis model assessment (HOMA-IR). RESULTS: A significant correlation between serum @entity12 and ferritin levels was found (r = 0.393, p < 0.05). @entity12 was independently correlated with ferritin after adjustment for age, gender, place of residence, education, income, leisure-time physical activity, drinking, smoking, body mass index, systolic pressure, diastolic pressure, @entity11 , @entity10 , @entity9 aminotransferase, @entity8 aminotransferase, total @entity1 , low density lipoprotein- @entity1 , @entity3 , high density lipoprotein- @entity1 , fasting plasma @entity4 , 2-hour postprandial plasma @entity4 , @entity5 , and urinary albumin to @entity6 ratio (p < 0.05). Positive correlations were established between @entity12 (standard b = 0.252) or ferritin (standard b = 0.181) after adjustment for multiple confounders (p < 0.05). CONCLUSIONS: @entity7 resistance is associated with elevated serum @entity12 and ferritin. A combined determination of @entity12 and ferritin might lead to better predictions in @entity0 with @entity7 resistance.

title: Serum Gamma-Glutamyltransferase and Ferritin are Related to XXXX Resistance: A Population-Based Study.

answer: @entity7


abstract: BACKGROUND: Chemoresistance is a leading cause of treatment failure in advanced @entity0 , including that with the extensively prescribed @entity3 . Recently, a series of structurally unique @entity5 ( @entity5 ) that act as antagonists of inhibitor of apoptosis proteins (IAPs) have been discovered, exhibiting the ability of inducing enhanced apoptosis of various @entity1 cell types when combined with chemotherapy. In the present study, we synthesized the second mitochondria-derived activator of caspase peptide ( @entity5 -N7 for short) and explored its capacity in combination with @entity3 in vitro. METHODS: The sensitivity assay and reversal ability of @entity5 -N7 were tested by @entity2 . Flow cytometry was used to analyze apoptosis of cells with @entity4 /PI double staining technique. Cell cloning ability was performed to reflect its biological behavior in each group. RESULTS: Concentrations with inhibitory rates < 10% were selected as the reversal value of @entity5 -N7 peptide using @entity2 . The reversal folds were 2.52, 3.26, 3.67, and 5.4 in @entity3 + @entity5 -N7 (0.0390625, 0.078125, 0.15625, 0.3125  g/mL, respectively), and concentrations of @entity5 -N7 and reversal folds appeared in an obvious positive correlation (r(s) = 1, p = 0.000). Apoptosis analyzed at 48 hours by flow cytometry showed the apoptotic rates in @entity3 and 0.0390625, 0.078125, 0.15625, and 0.3125  g/mL @entity5 -N7 + @entity3 groups were 15.4    1.09%, 20.8%    2.18%, 28.4%    4.17%, 37.64%    6.41%, and 46.6%    7.76%, respectively. Concentrations of @entity5 -N7 appeared to have negative correlations with PE and SF (r(s) = -1, p < 0.05), which showed that the cells' cloning ability in 0.3125  g/mL @entity5 -N7 + @entity3 group was worse than that of other groups. CONCLUSIONS: When combined with @entity3 , 0.3125  g/mL @entity5 -N7 peptide may significantly increase @entity3 -induced apoptosis in chemoresistant A549/ @entity3 lung cells at 48 hours, and is potentially useful as a reversal agent in @entity0 therapy.

title: Reversal of Chemoresistance in Human Lung Cancer Cell Line A549/ XXXX by Synthetic Second Mitochondria-Derived Activator of Caspase Peptide.

answer: @entity3


abstract: The @entity2 Inventory is a clinical instrument for assessing behavioral and psychological symptoms in @entity3 . It is based on an interview with the primary caregiver. A brief questionnaire form of the NPI was developed, intended for use in routine clinical practice (NPI-Q). This study evaluates the validity of the NPI-Q Dutch form. The NPI-Q was compared to other questionnaires, i.e. the Revised Memory and Behavioural Problems Checklist (RMBPC), the short form Informant Questionnaire on @entity1 in the Elderly (IQCODE-N), the 15 items Geriatric @entity4 Scale (GDS-15) and the Cognitive Screening Test (CST-20). A data set was used of geriatric outpatients who were referred for neuropsychological assessment (n = 29). Correlations between the NPI-Q and RMBPC @entity4 - and Disinhibition subscales were relatively high. No relationship was found between the NPI-Q and the RMBPC Memory related behavioral changes subscale, or between the NPI-Q and the IQCODE-N and the CST-20. Informant ratings on the NPI-Q depression-item were related with @entity0 ratings on the GDS-15, especially when @entity0 were relatively mildly @entity1 . Caregiver distress was strongly associated with NPI-Q symptom assessment. IN CONCLUSION: our preliminary results support validity of the NPI-Q Dutch form. It is a practical rating scale for assessing @entity2 in @entity3 and associated caregiver distress.

title: [ XXXX inventory questionnaire (NPI-Q): A validity study of the Dutch form].

answer: @entity2


abstract: Alcohol intolerance after consumption of wild mushrooms is a recognized phenomenon. This is best understood with Coprinus atramentarius. Its active component @entity7 blocks enzymatic @entity4 degradation at the stage of @entity6 , which is responsible for the well-recognized symptoms. Here, we report three events in five @entity0 experiencing the same symptoms after consumption of self-collected Lepiota aspera. All had mistaken L. aspera for edible mushrooms as Amanita rubescens or Macrolepiota procera. In all events, L. aspera was identified by mycologists and no other mushrooms were involved. The mushrooms were well saut  ed and tolerated well until an alcoholic beverage was consumed. Then within few minutes facial flushing, throbbing @entity1 , @entity3 , and @entity5 all occurred. The symptoms abated within a few hours with no sequelae but could be re-provoked by further @entity2 consumption up to 48 h later. This syndrome appears to be identical with the one known from C. atramentarius. However, the toxin in L. aspera or its mechanism is not yet known.

title: Case series: @entity2 intolerance with XXXX -like syndrome after consumption of the mushroom Lepiota aspera (Pers.:Fr.) Qu  l., 1886 (Freckled Dapperling).

answer: @entity7


abstract: Alcohol intolerance after consumption of wild mushrooms is a recognized phenomenon. This is best understood with Coprinus atramentarius. Its active component @entity7 blocks enzymatic @entity4 degradation at the stage of @entity6 , which is responsible for the well-recognized symptoms. Here, we report three events in five @entity0 experiencing the same symptoms after consumption of self-collected Lepiota aspera. All had mistaken L. aspera for edible mushrooms as Amanita rubescens or Macrolepiota procera. In all events, L. aspera was identified by mycologists and no other mushrooms were involved. The mushrooms were well saut  ed and tolerated well until an alcoholic beverage was consumed. Then within few minutes facial flushing, throbbing @entity1 , @entity3 , and @entity5 all occurred. The symptoms abated within a few hours with no sequelae but could be re-provoked by further @entity2 consumption up to 48 h later. This syndrome appears to be identical with the one known from C. atramentarius. However, the toxin in L. aspera or its mechanism is not yet known.

title: Case series: XXXX intolerance with @entity7 -like syndrome after consumption of the mushroom Lepiota aspera (Pers.:Fr.) Qu  l., 1886 (Freckled Dapperling).

answer: @entity2


abstract: BACKGROUND: @entity3 have shown promise as an adjunctive treatment for @entity1 . However, efficacy across studies has been inconsistent. We conducted a meta-analysis of published controlled studies with the goal of detecting different efficacy profiles at various stages of @entity1 . METHODS: An online search was conducted for randomized, double-blind, placebo-controlled clinical trials, and a meta-analysis was conducted. RESULTS: Ten studies met the criteria for inclusion. Among @entity0 in the prodromal phase of @entity1 , omega-3 supplementation reduced psychotic symptom severity and lowered conversion rates to first-episode @entity2 . In @entity0 with first-episode @entity1 , omega-3 decreased nonpsychotic symptoms, required lower antipsychotic medication dosages, and improved early treatment response rates. Omega-3 had mixed results in @entity0 with stable chronic @entity1 , with only some @entity0 experiencing significant benefits. Among @entity0 with chronic @entity1 , use of @entity3 both by those experiencing acute exacerbations and those who had discontinued antipsychotic medications resulted in worsening of @entity2 . CONCLUSIONS: The data suggest that @entity3 may be efficacious in reducing clinical symptoms for @entity0 in the earlier stages of @entity1 (prodrome and first episode), while producing mixed results for @entity0 in the chronic stages. Based on these results, @entity3 would not be recommended for acute exacerbations in @entity0 with chronic @entity1 nor for relapse prevention after discontinuation of antipsychotics.

title: A meta-analysis of placebo-controlled trials of omega-3 fatty acid augmentation in XXXX : Possible stage-specific effects.

answer: @entity1


abstract: @entity5 is characterized by the occurrence of frequent spontaneous @entity6 . If inadequately treated, it results in progressive @entity2 leading to @entity1 . These complications result in lifelong chronic @entity3 and disability that may greatly affect the @entity0 ' mood. We aimed to evaluate the musculoskeletal function in our @entity5 @entity0 and its correlation to depressed mood in these @entity0 and determine the impact of degree of @entity5 , different replacement therapy regimens and frequency of @entity7 , on both musculoskeletal function and mood. A cross-sectional study was carried out on 50 adolescent @entity5 @entity0 . Musculoskeletal function was assessed using Functional Independence Score for @entity5 (FISH) and mood status was assessed using Beck Depression Inventory-Short Form (BDI-SF). The mean FISH score was 23.32    4.69 (range 13-28) and the tasks that obtained lower scores were step climbing, squatting and walking. Of our 50 @entity0 included, 16(32%) were not depressed, 18(36%) were with mild @entity4 , 11(22%) were with moderate @entity4 and 5(10%) were with severe @entity4 . There was a highly significant negative correlation between mean FISH score and mean BDI-SF score (P < 0.001). The better the replacement therapy regimen, the better the musculoskeletal function that could be obtained in @entity5 @entity0 and the better the mood.

title: Assessment of musculoskeletal function and mood in XXXX adolescents: a cross-sectional study.

answer: @entity5


abstract: AIM: Percutaneous @entity1 repair (p-EVAR), has been widely spread based on the recent improvements in stent-graft technology and mainly in delivery system downsizing. Aim of this study is to investigate the safety and efficacy of fascia suture technique (FST) in p-EVAR during the short and mid-term follow up (FU). METHODS: Between April 2011 and July 2013, 64 consecutive @entity0 with @entity2 were enrolled in a prospective single center registry. 54 @entity0 were eligible for elective p-EVAR assisted by the fascia suture technique. @entity0 were prospectively followed with duplex scan 24 hours and 30 days postoperatively and with CTA annually thereafter. Femoral haematoma, @entity3 and limb ischaemia were the primary outcomes. RESULTS: The study investigated 103 femoral arteries reconstructions using the FST. Intraoperatively, one @entity0 was diagnosed with limb ischaemia treated with open repair. During the short-term, 4 (3.8%) @entity3 were diagnosed, treated with open (2) or endovascular (2) repair. During mid-term 43 @entity0 (85 arteries) 82,6% underwent CTA. Eighteen (17.4%) @entity0 were lost of FU. At 12 months CTA two @entity3 (2.35%) were detected, treated with open repair. CONCLUSION: The FST seems safe and effective for femoral reconstruction after p- EVAR. Complications are comparable to closure devices and to conventional repair.

title: XXXX repair with Fascia suture technique: short and mid- term results.

answer: @entity1


abstract: Following the discovery of a @entity5 ( @entity5 ), the classical approach consists of treatment with non-fractionated heparin (NFH) followed by oral anticoagulants. The use of NFH for this indication has only been evaluated in one open, non randomised study of 23 @entity0 with no control group. Low molecular weight heparins (LMWH) have not been the object of any study although they are routinely used by certain teams. The objective of this study was to evaluate the feasibility of the use of LMWH in the treatment of @entity5 . This was an open, non randomised prospective study. All @entity0 having a newly diagnosed @entity5 between September 2000 and September 2002 were treated with @entity7 (100 IU/kg twice daily) for an average duration of 13 days; replacement with @entity8 was started on the fifth day. The progression of the @entity5 was followed using twice weekly transthoracic echocardiography for 3 weeks. RESULTS: 19 @entity5 were discovered in 2 years (13 complicating an anterior @entity6 and 6 with a @entity1 ). The average area was between 2.64 +/- 0.41 cm2 and 0.43 +/- 0.21 cm2 (p < 0.0001). Thirteen out of 19 thrombi disappeared with treatment (68.5%). There was no @entity4 or @entity2 . One transient ischaemic attack was noted. CONCLUSION: This preliminary work shows that LMWH are well tolerated and effective to make a @entity3 disappear or to reduce its size.

title: [Treatment of left intraventricular XXXX with low molecular weight heparin].

answer: @entity3


abstract: BACKGROUND: Copy number alterations (CNA) play a key role in @entity0 development and progression. Since more than one CNA can be detected in most @entity0 , frequently co-occurring genetic CNA may point to cooperating @entity0 related genes. Existing methods for co-occurrence evaluation so far have not considered the overall heterogeneity of CNA per @entity0 , resulting in a preferential detection of frequent changes with limited specificity for each association due to the high genetic instability of many samples. METHOD: We hypothesize that in @entity0 some linkage-independent CNA may display a non-random co-occurrence, and that these CNA could be of pathogenetic relevance for the respective @entity0 . We also hypothesize that the statistical relevance of co-occurring CNA may depend on the sample specific CNA complexity. We verify our hypotheses with a simulation based algorithm CDCOCA (complexity dependence of co-occurring @entity1 ). RESULTS: Application of CDCOCA to example data sets identified co-occurring CNA from low complex background which otherwise went unnoticed. Identification of @entity0 associated genes in these co-occurring changes can provide insights of cooperative genes involved in oncogenesis. CONCLUSIONS: We have developed a method to detect associations of regional copy number abnormalities in @entity0 data. Along with finding statistically relevant CNA co-occurrences, our algorithm points towards a generally low specificity for co-occurrence of regional imbalances in CNA rich samples, which may have negative impact on pathway modeling approaches relying on frequent CNA events.

title: CDCOCA: a statistical method to define complexity dependence of co-occuring XXXX .

answer: @entity1


abstract: STUDY QUESTION: What are the diagnostic yield and accuracy of early computed tomography (CT) angiography followed by magnetic resonance imaging/angiography (MRI/MRA) and digital subtraction angiography (DSA) in @entity0 with non-traumatic @entity3 ? METHODS: This prospective diagnostic study enrolled 298 adults (18-70 years) treated in 22 hospitals in the Netherlands over six years. CT angiography was performed within seven days of @entity2 . If the result was negative, MRI/MRA was performed four to eight weeks later. DSA was performed when the CT angiography or MRI/MRA results were inconclusive or negative. The main outcome was a macrovascular cause, including @entity5 , @entity1 , @entity4 , and cavernoma. Three blinded neuroradiologists independently evaluated the images for macrovascular causes of @entity2 . The reference standard was the best available evidence from all findings during one year's follow-up. STUDY ANSWER AND LIMITATIONS: A macrovascular cause was identified in 69 @entity0 (23%). 291 @entity0 (98%) underwent CT angiography; 214 with a negative result underwent additional MRI/MRA and 97 with a negative result for both CT angiography and MRI/MRA underwent DSA. Early CT angiography detected 51 macrovascular causes (yield 17%, 95% confidence interval 13% to 22%). CT angiography with MRI/MRA identified two additional macrovascular causes (18%, 14% to 23%) and these modalities combined with DSA another 15 (23%, 18% to 28%). This last extensive strategy failed to detect a cavernoma, which was identified on MRI during follow-up (reference strategy). The positive predictive value of CT angiography was 72% (60% to 82%), of additional MRI/MRA was 35% (14% to 62%), and of additional DSA was 100% (75% to 100%). None of the @entity0 experienced complications with CT angiography or MRI/MRA; 0.6% of @entity0 who underwent DSA experienced permanent sequelae. Not all @entity0 with negative CT angiography and MRI/MRA results underwent DSA. Although the previous probability of finding a macrovascular cause was lower in @entity0 who did not undergo DSA, some small @entity5 or @entity4 may have been missed. WHAT THIS STUDY ADDS: CT angiography is an appropriate initial investigation to detect macrovascular causes of non-traumatic @entity3 , but accuracy is modest. Additional MRI/MRA may find cavernomas or alternative diagnoses, but DSA is needed to diagnose macrovascular causes undetected by CT angiography or MRI/MRA. FUNDING, COMPETING INTERESTS, DATA SHARING: Dutch Heart Foundation and The Netherlands Organisation for Health Research and Development, ZonMw. The authors have no competing interests. Direct requests for additional data to the corresponding author.

title: Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of XXXX : prospective, multicentre cohort study.

answer: @entity3


abstract: UNASSIGNED: The technique of electroencephalographic neurofeedback (EEG  NF) emerged in the 1970s and is a technique that measures a subject's EEG signal, processes it in real time, extracts a parameter of interest and presents this information in visual or auditory form. The goal is to effectuate a behavioural modification by modulating brain activity. The EEG  NF opens new therapeutic possibilities in the fields of psychiatry and neurology. However, the development of EEG  NF in clinical practice requires (i) a good level of evidence of therapeutic efficacy of this technique, (ii) a good practice guide for this technique. Firstly, this article investigates selected trials with the following criteria: study design with controlled, randomized, and open or blind protocol, primary endpoint related to the @entity4 treated and assessed with standardized measurement tools, identifiable EEG neurophysiological targets, underpinned by pathophysiological relevance. Trials were found for: @entity6 , @entity9 , @entity1 , chronic @entity0 , @entity2 ( @entity2 ), @entity3 , major @entity7 , @entity5 , addictive disorders, @entity8 . Secondly, this article investigates the principles of neurofeedback therapy in line with learning theory. Different underlying therapeutic models are presented didactically between two continua: a continuum between implicit and explicit learning and a continuum between the biomedical model (centred on "the disease") and integrative biopsychosocial model of health (centred on "the illness"). The main relevant learning model is to link neurofeedback therapy with the field of cognitive remediation techniques. The methodological specificity of neurofeedback is to be guided by biologically relevant neurophysiological parameters. Guidelines for good clinical practice of EEG  NF concerning technical issues of electrophysiology and of learning are suggested. These require validation by institutional structures for the clinical practice of EEG  NF.

title: Electroencephalographic neurofeedback: Level of evidence in XXXX and suggestions for good clinical practice.

answer: @entity4


abstract: Fibrosing @entity8 is caused by a proliferation of fibrous tissue in the mediastinum with encasement of mediastinal viscera and compression of mediastinal bronchovascular structures. @entity1 ( @entity1 ) is a severe complication of fibrosing @entity8 caused by extrinsic compression of the pulmonary arteries and/or veins.We have conducted a retrospective observational study reviewing clinical, functional, hemodynamic, radiological characteristics, and outcome of 27 consecutive cases of @entity1 associated with fibrosing @entity8 diagnosed between 2003 and 2014 at the French Referral Centre for @entity1 .Fourteen @entity0 and 13 @entity0 with a median age of 60 years (range 18-84) had @entity1 confirmed on right heart catheterization. The causes of fibrosing @entity8 were @entity5 (n=13), @entity6 confirmed or suspected (n=9), mediastinal irradiation (n=2), and idiopathic (n=3). Sixteen @entity0 (59%) were in NYHA functional class III and IV. Right heart catheterization confirmed moderate to severe @entity1 with a median mean pulmonary artery pressure of 42 mm Hg (range 27-90) and a median cardiac index of 2.8 L/min/m (range 1.6-4.3). Precapillary @entity1 was found in 22 @entity0 , postcapillary @entity1 in 2, and combined postcapillary and precapillary @entity1 in 3. Severe extrinsic compression of pulmonary arteries (>60% reduction in diameter) was evidenced in 2, 8, and 12 @entity0 at the main, lobar, or segmental levels, respectively. Fourteen @entity0 had at least one severe @entity4 with associated @entity7 in 6 of them. @entity9 therapy was initiated in 7 @entity0 and corticosteroid therapy (0.5-1mg/kg/day) was initiated in 3 @entity0 with @entity5 , with 9 other being already on low-dose @entity3 . At 1-year follow-up, 3 @entity0 had died and among the 21 @entity0 evaluated, 3 deteriorated, 14 were stable, and only 4 @entity0 with @entity5 improved (4 receiving corticosteroids and 1 receiving corticosteroids and @entity9 therapy). Survival was 88%, 73%, and 56% at 1, 3, and 5 years, respectively.We found no clear clinical improvement with the use of specific @entity9 therapy. @entity2 therapy may be associated with clinical improvement, in some @entity0 with fibrosing @entity8 due to @entity5 . Although never performed for this indication, lung transplantation may be proposed in eligible @entity0 with severe @entity1 and fibrosing @entity8 .

title: XXXX Complicating Fibrosing @entity8 .

answer: @entity1


abstract: Fibrosing @entity8 is caused by a proliferation of fibrous tissue in the mediastinum with encasement of mediastinal viscera and compression of mediastinal bronchovascular structures. @entity1 ( @entity1 ) is a severe complication of fibrosing @entity8 caused by extrinsic compression of the pulmonary arteries and/or veins.We have conducted a retrospective observational study reviewing clinical, functional, hemodynamic, radiological characteristics, and outcome of 27 consecutive cases of @entity1 associated with fibrosing @entity8 diagnosed between 2003 and 2014 at the French Referral Centre for @entity1 .Fourteen @entity0 and 13 @entity0 with a median age of 60 years (range 18-84) had @entity1 confirmed on right heart catheterization. The causes of fibrosing @entity8 were @entity5 (n=13), @entity6 confirmed or suspected (n=9), mediastinal irradiation (n=2), and idiopathic (n=3). Sixteen @entity0 (59%) were in NYHA functional class III and IV. Right heart catheterization confirmed moderate to severe @entity1 with a median mean pulmonary artery pressure of 42 mm Hg (range 27-90) and a median cardiac index of 2.8 L/min/m (range 1.6-4.3). Precapillary @entity1 was found in 22 @entity0 , postcapillary @entity1 in 2, and combined postcapillary and precapillary @entity1 in 3. Severe extrinsic compression of pulmonary arteries (>60% reduction in diameter) was evidenced in 2, 8, and 12 @entity0 at the main, lobar, or segmental levels, respectively. Fourteen @entity0 had at least one severe @entity4 with associated @entity7 in 6 of them. @entity9 therapy was initiated in 7 @entity0 and corticosteroid therapy (0.5-1mg/kg/day) was initiated in 3 @entity0 with @entity5 , with 9 other being already on low-dose @entity3 . At 1-year follow-up, 3 @entity0 had died and among the 21 @entity0 evaluated, 3 deteriorated, 14 were stable, and only 4 @entity0 with @entity5 improved (4 receiving corticosteroids and 1 receiving corticosteroids and @entity9 therapy). Survival was 88%, 73%, and 56% at 1, 3, and 5 years, respectively.We found no clear clinical improvement with the use of specific @entity9 therapy. @entity2 therapy may be associated with clinical improvement, in some @entity0 with fibrosing @entity8 due to @entity5 . Although never performed for this indication, lung transplantation may be proposed in eligible @entity0 with severe @entity1 and fibrosing @entity8 .

title: @entity1 Complicating Fibrosing XXXX .

answer: @entity8


abstract: INTRODUCTION: @entity1 ( @entity1 ) gene polymorphisms have been studied in different ethnic populations. We assessed the @entity1 gene insertion/deletion alleles frequencies and genotype distributions in a group of individuals from among the general population of west Azarbaijan, Iran, in order to determine the prevalence of deletion/deletion (D/D), deletion/insertion (D/I) and insertion/insertion (I/I) genotypes. MATERIALS AND METHODS: In a cross-sectional study, 167 healthy individuals were enrolled in a randomized fashion. They were selected from the general population of west Azerbaijan, Iran. Polymerase chain reaction was carried out to determine the @entity1 D/D, D/I and I/I genotypes. RESULTS: The @entity1 alleles were D and I in 59.7% and 40.3% of the @entity0 , 59.3% and 40.7% of the @entity0 and 59.6% and 40.4% of all of the @entity0 , respectively. The D/D, D/I, and I/I genotypes were observed in 22 (40.7%), 20 (37%), and 12 (22.2%) @entity0 , 41 (36.3%), 53 (46.9%), and 19 (16.8%) @entity0 , and 63 (37.7%), 73 (43.7%), and 31 (18.6%) @entity0 , respectively. Statistical analysis showed that differences in @entity1 D and I alleles and genotype frequencies were not significant between the @entity0 and the @entity0 . CONCLUSIONS: In this study on the general population of west Azarbaijan, the frequencies of the @entity1 D and I alleles were 59.6% and 40.4%. The @entity1 D/D, D/I and I/I genotypes were seen in 37.7%, 43.7%, and 18.6% of the studied population, respectively.

title: XXXX insertion/deletion gene polymorphism in general population of west Azarbaijan, Iran.

answer: @entity1


abstract: BACKGROUND: Twenty years ago an average of 1.5 Heller myotomies were performed per year in our hospital, mostly for @entity0 whose @entity2 did not improve following @entity1 or whose esophagus had been perforated during a @entity1 . Ten years ago we started using minimally invasive surgery to treat this disease. STUDY DESIGN: This study measures the impact of minimally invasive surgery with regard to the following: the number of @entity0 referred for treatment; the number of @entity0 who came to surgery without previous treatment; and the results of surgical treatment. Between 1991 and 2001, 149 @entity0 had minimally invasive surgery for @entity3 : 25 @entity0 (17%) had thoracoscopic Heller myotomy and 124 (84%) had laparoscopic Heller myotomy and Dor fundoplication. Of the 149 @entity0 , 79 @entity0 (53%) had previous treatment (56 @entity0 [71%], @entity1 ; 7 @entity0 [9%], botulinum toxin injection; 16 @entity0 [20%], both) and 70 @entity0 (43%) had none of these treatments. Mean postoperative followup was 59 +/- 36 months. @entity0 were divided into two groups: group A, operated on between 1991 and 1995; and group B, operated on between 1996 and 2001. RESULTS: In the past decade, the number of @entity0 referred for surgery has increased substantially--group A, 48; group B, 101; an increasing proportion of @entity0 were referred for surgery without previous treatment--group A, 38%; group B, 51%; and the outcomes of the operation progressively improved--group A, 87%; group B, 95%. CONCLUSIONS: These data show that the high success rate of laparoscopic Heller myotomy for @entity3 has brought a shift in practice; surgery has become the preferred treatment of most gastroenterologists and other referring physicians. This has followed documentation that laparoscopic treatment outperforms @entity1 and botulinum toxin injection.

title: Impact of minimally invasive surgery on the treatment of XXXX : a decade of change.

answer: @entity3


abstract: The retina is an easily accessible part of the CNS with a well-defined cytological architecture. It allows for detailed study of the regulation of neurogenesis, determinants of cell fate specification, and signals for cell survival versus programmed cellular death during development. Within the retina, @entity4 cells (RGCs) are the only neurons connecting to the brain. Their axonal projection to the midbrain targets, the superior colliculus (SC), and the lateral geniculate nucleus (LGN) has been subject of a number of investigations, and led to the identification of molecular signals directing topographic information for precise wiring during development. Transcription factors, guidance molecules, extracellular matrix proteins, neurotrophic factors, and cell death-regulating factors of the @entity2 family and caspases, have all been reported to be involved in the processes of formation of a precise retino-collicular map, and regulation of developmental cell death.During adulthood, RGCs and their projection have to be maintained, since-to our current knowledge-they cannot be replaced following injury. On the other hand, insults of various kinds can be potentially hazardous to RGCs. Therefore, much work has been directed towards understanding of the molecular regulation of @entity1 following insults such as @entity4 , @entity0 , or in @entity3 . Experimental strategies are being devised towards protection of lesioned RGCs. Since following @entity0 , these cells not only need to survive, but also have to reconnect in order to be functionally relevant, efforts are directed towards not only survival, but also axonal regeneration and proper rewiring of injured RGCs. This paper reviews the molecular determinants of RGC fate determination and the development of the retino-tectal projection. We summarize what is known (and hypothesized) on the determinants of RGC survival during normal adulthood, and the mechanisms of @entity1 in the injured retina. We also try to develop perspectives towards neuroprotection and regeneration of adult lesioned RGCs that may be applicable to lesioned CNS neurons in vertebrates in a broader sense.

title: Molecular determinants of XXXX cell development, survival, and regeneration.

answer: @entity4


abstract: OBJECTIVES: The aim of this study was to describe the correlation between changes in structural abnormalities assessed on MRI and change in radiographic @entity1 ( @entity1 ) over 10 years in a midlife cohort. METHODS: 211 @entity0 [mean-age 45 (26-61); 57% female] were studied at baseline, two and ten years. Approximately, half were adult offspring of subjects who had undergone knee replacement for @entity1 and the remainder were randomly selected controls. Joint space narrowing (JSN) and @entity3 were assessed from radiographs while cartilage volume, cartilage defects and @entity2 /extrusion were assessed from MRI. Spearman ranked correlation analysis was used to describe the correlation between structural changes assessed on MRI and radiographs. Only medial tibiofemoral compartment results are presented as the lateral compartment had limited change. RESULTS: Over ten years, @entity2 showed a moderate independent correlation with change in both JSN (  =+0.37, p=<0.01) and @entity3 (  =+0.31, p=<0.01) in the adjusted analysis. Meniscal extrusion (  =+0.22, p=<0.01) and cartilage defects (  =+0.16, p=0.04) showed a slightly weaker independent correlation with JSN in the adjusted analysis, whereas cartilage volume loss showed no significant correlation with either of the two radiographic outcomes. CONCLUSION: Change in JSN is correlated with @entity2 and, to a lesser extent, with meniscal extrusion and cartilage defects. In this sample, change in JSN is a composite measure that does not reflect cartilage volume loss prompting the review of the use of JSN as an outcome measure in chondro-protective drug trials. This article is protected by copyright. All rights reserved.

title: Correlation between changes in global knee structures assessed on MRI and radiographic XXXX changes over 10 years in a mid-life cohort.

answer: @entity1


abstract: Several studies have shown that @entity2 cells may develop resistance to radiotherapy, proliferating under @entity6 conditions. Following surgery, @entity0 may develop low hemoglobin levels, which may cause low @entity3 conditions. This retrospective analysis was undertaken to determine the impact of low hemoglobin levels in @entity0 with @entity4 treated with combined-modality therapy (surgery and postoperative radiochemotherapy). We studied 120 @entity0 with mostly advanced @entity4 (88% stage III/IV) who had undergone macroscopically complete resections of their primary @entity2 and lymph node @entity1 . At 20-277 days after surgery (median: 51.3 days), these @entity0 received postoperative chemoradiotherapy (56.7 Gy of radiation over 28-49 days and @entity7 6 mg/m(2) body surface area on radiation treatment days with a cumulative dose of 96 mg/m(2)). Normal hemoglobin levels were considered to be 12 g/dl for females and 13 g/dl for males. Decreased hemoglobin levels before or after surgery and before or after chemoradiotherapy were correlated with the prognosis. Preoperatively, 99 of 114 @entity0 (87%) had normal levels of hemoglobin compared with only 20 of 107 @entity0 (19%) postoperatively. At the onset of radiochemotherapy, the hemoglobin levels of 82 of 116 @entity0 (71%) were within the normal range. After radiochemotherapy, however, 62 of 114 @entity0 (54%) had normal hemoglobin levels. Univariate analysis (Kaplan-Meier method and log-rank test) showed that @entity0 with decreased pre- or postoperative hemoglobin levels had significantly worse locoregional control ( P=0.032 and P=0.0001, respectively) and lower overall survival ( P=0.0013 and P=0.0002, respectively) than @entity0 with normal hemoglobin levels. The 3-year locoregional control rates in @entity0 with preoperative hemoglobin levels that were normal, were reduced by 1-2 g/dl or were reduced by more than 3 g/dl, respectively, were 78%, 55% and 50%. Correlated with normal and diminished postoperative hemoglobin levels, the 3-year locoregional control rates were 90%, 84% and 50%, respectively. There was no correlation between prognosis and hemoglobin level at the onset or after radiochemotherapy. On multivariate analysis, only the postoperative hemoglobin level remained a prognostic factor for locoregional control ( P=0.0241) and overall survival ( P=0.0080). We conclude that low postoperative hemoglobin levels resulting from @entity5 may influence the efficacy of postoperative radiochemotherapy in @entity0 with @entity4 . Early intervention to raise the postoperative hemoglobin level may result in @entity2 control and overall survival after combined-modality therapy.

title: Prognostic implications of hemoglobin levels before and after surgery as well as before and after radiochemotherapy for XXXX .

answer: @entity4