abstract: @entity4 ( @entity4 ) is a rare @entity10 occurring in the distal extremities of young adults and is characterized histologically by nodules of epithelioid cells showing central @entity2 . Intra-articular @entity4 is extremely rare; only four cases have been reported, but their radiologic and histologic documentation of intra-articular origin have been imprecise. We report the first radiologically and histologically well-documented case of primary synovial @entity4 . A 59-year-old @entity0 presented with @entity3 followed by swelling of her right knee for 6  months. MRI revealed an entirely intra-articular nodular synovial mass in the lateral part of the right knee joint in a background of diffusely thickened synovium. Synovectomy was performed under the clinical impression of @entity6 ( @entity6 ), a diagnosis erroneously confirmed by the reporting pathologist. The @entity1 rapidly recurred 3  months afterward and the diagnosis of primary synovial @entity4 was made. Despite above-knee amputation, the @entity1 continued to spread proximally to the retroperitoneum. She developed multiple lung metastases and died 20  months after initial presentation. The nodular aggregates of @entity1 cells with central @entity2 resulted in diffuse polypoid synovial thickening mimicking @entity5 and @entity6 . The @entity1 cells showed positive staining for EMA, @entity8 , @entity7 , and complete loss of @entity9 staining, establishing the diagnosis of primary synovial @entity4 . The @entity4 spread from the synovium to and along the joint capsule, and then extra-articularly into the soft tissue surrounding the knee joint, with lymphovascular permeation. Such pattern of spread calls for radical surgical excision as the treatment of choice.

title: Primary synovial epithelioid sarcoma of the knee: distinctly unusual location leading to its confusion with XXXX .

answer: @entity6


abstract: INTRODUCTION: Surgical treatment of intestinal @entity4 ( @entity4 ) is not well established. Specifically, it is still difficult to assess the clinical value of laparoscopic surgery to address this condition. We aimed to evaluate the clinical course and the characteristics of laparoscopic surgery for intestinal @entity4 compared with open surgery. METHODS: We reviewed charts of 91 @entity0 who underwent surgical treatment for intestinal @entity4 between January 1995 and December 2012. We retrospectively compared the laparoscopic group (LG, n  =  30) and the open group (OG, n  =  61) in terms of @entity0 demographics, clinical features, operative data, postoperative course, complications within 30  days after operation, and long-term follow-up data. RESULTS: There were more females in the LG than in the OG (63.3 vs. 36.1  %, p  =  0.014), and @entity5 were more frequent in the LG (76.7 vs. 54.1  %, p  =  0.038; 60 vs. 36.1  %, p  =  0.031). Intractability with medical treatment was dominant in the LG (76.7 vs. 45.9  %, p  =  0.02), while intestinal perforation or @entity3 were more prevalent in the OG (10 vs. 44.3  %, p  =  0.001). Most @entity0 received an ileocecectomy or a right hemicolectomy as their first surgery. In the LG, the @entity0 had a shorter operation time (162.0 vs. 228.5  min, p  <  0.001) and had less @entity1 (61.7 vs. 232.3  ml, p  =  0.003). There were no significant @entity2 , reoperation, mortality, and hospital stay between the groups. During the follow-up period, the mean number of operations was less in the LG than in the OG (1.3 vs. 2.1, p  =  0.011). Analysis indicated that 20  % of @entity0 in the LG and 50.8  % in the OG underwent more than two operations (p  =  0.005). CONCLUSION: Laparoscopic surgery is feasible and safe for selected intestinal @entity4 @entity0 . However, there were no better short-term outcomes in LG compared with OG.

title: Short- and long-term outcomes of laparoscopic surgery for intestinal XXXX : a comparative study with open surgery.

answer: @entity4


abstract: OBJECTIVES: Individual differences in underlying, "basal" @entity2 sensitivity are large and have clinical implications. Some studies have suggested that @entity2 sensitivity may also predict the outcome of @entity2 treatment. @entity4 management programs are effective, but treatment success is individually very different. Therefore, identification of predictors of treatment success is important. This study investigated if @entity2 sensitivity predicted the outcome of a 4-week outpatient multidisciplinary @entity2 management program. DESIGN: Cohort study. SETTING: @entity4 outpatient clinic at the Department of Anesthesiology, Intensive Care Medicine and Pain Therapy of the University of M  nster. METHODS: @entity2 sensitivity was measured at treatment onset, using comprehensive experimental @entity2 testing (thermal, pressure, and @entity2 ) and the @entity2 sensitivity questionnaire. Primary (clinical @entity2 intensity) and secondary ( @entity3 , @entity1 , @entity2 ) outcome parameters were assessed at treatment start, at discharge and 6 months later. SUBJECTS: Sixty five adult chronic @entity2 @entity0 with mixed @entity2 diagnoses. RESULTS: There were significant improvements in clinical @entity2 intensity (from 6.1        2.0 to 5.1        1.8 [0-10]), @entity3 and @entity1 at discharge (all P   <   0.001) and of clinical @entity2 intensity (to 5.3        2.3 [0-10]) and @entity2 at 6 months (all P   <   0.05). However, treatment outcome was not predicted by any of the @entity2 sensitivity measures. DISCUSSION: Results show that @entity2 sensitivity is not a reliable predictor of treatment outcome in mixed diagnosis multidisciplinary @entity2 management programs, possibly due to the heterogeneity of @entity0 enrolled in such programs. Clinically useful predictors of treatment success in this setting remain to be identified.

title: Basal Pain Sensitivity does not Predict the Outcome of XXXX Treatment.

answer: @entity4


abstract: BACKGROUND: The high recurrence rate of chronic @entity3 has a significant impact on an individual's quality of life and healthcare costs. OBJECTIVES: This study aimed to identify risk and protective factors for recurrence of @entity3 using a theoretical approach by applying a framework of self and family management of chronic conditions to underpin the study. DESIGN: Secondary analysis of combined data collected from three previous prospective longitudinal studies. SETTING: The contributing studies' @entity0 were recruited from two metropolitan hospital outpatient wound clinics and three community-based wound clinics. @entity0 : Data were available on a sample of 250 adults, with a leg @entity1 of primarily venous aetiology, who were followed after @entity1 for a median follow-up time of 17 months after healing (range: 3-36 months). METHODS: Data from the three studies were combined. The original @entity0 data were collected through medical records and self-reported questionnaires upon healing and every 3 months thereafter. A Cox proportion-hazards regression analysis was undertaken to determine the influential factors on leg @entity1 recurrence based on the proposed conceptual framework. RESULTS: The median time to recurrence was 42 weeks (95% CI 31.9-52.0), with an incidence of 22% (54 of 250 @entity0 ) recurrence within three months of healing, 39% (91 of 235 @entity0 ) for those who were followed for six months, 57% (111 of 193) by 12 months, 73% (53 of 72) by two years and 78% (41 of 52) of those who were followed up for three years. A Cox proportional-hazards regression model revealed that the risk factors for recurrence included a history of @entity2 (HR 1.7, 95% CI 1.07-2.67, p=0.024), history of multiple previous leg ulcers (HR 4.4, 95% CI 1.84-10.5, p=0.001), and longer duration (in weeks) of previous @entity1 (HR 1.01, 95% CI 1.003-1.01, p<0.001); while the protective factors were elevating legs for at least 30min per day (HR 0.33, 95% CI 0.19-0.56, p<0.001), higher levels of self-efficacy (HR 0.95, 95% CI 0.92-0.99, p=0.016), and walking around for at least 3h/day (HR 0.66, 95% CI 0.44-0.98, p=0.040). CONCLUSIONS: Results from this study provide a comprehensive examination of risk and protective factors associated with leg @entity1 recurrence based on the chronic disease self and family management framework. These results in turn provide essential steps towards developing and testing interventions to promote optimal prevention strategies for @entity3 .

title: Identifying risk factors and protective factors for XXXX using a theoretical approach: A longitudinal study.

answer: @entity3


abstract: BACKGROUND: The purpose of this study was to observe the role of secondary cytoreductive surgery in @entity4 -resistant recurrent @entity2 ( @entity2 ) @entity0 . METHODS: We collected data of @entity0 affected by recurrent @entity2 treated between 1995 and 2013. Inclusion criteria were: invasive epithelial @entity2 histologically documented, cytoreductive surgery and @entity4 -based chemotherapy at first-line treat ment with evidence of complete response to treatment, disease-free interval <6  months, and no concomitant @entity1 . @entity0 considered susceptible of cytoreductive surgery (group A) were compared with a historical series of @entity0 with similar characteristics but not eligible for surgery (group B). RESULTS: Of 122 @entity4 -resistant @entity0 , 18 met the inclusion criteria for the study and were enrolled. They were compared with a historical series of 18 @entity0 not surgically treated with analogous clinical and pathological features. The most frequent sites of relapse included pelvic and aortic lymph nodes (39  %), peritoneum (33  %), bowel (28  %), and pelvis (22  %). A low rate of @entity3 was reported. No deaths were recorded. Overall survival was significantly longer in cytoreductive group when compared with the control group (P  =  0.035). Median overall survival was 44  months. Estimated 5-year overall survival rates were 57 versus 23.5  % for groups A and B, respectively. CONCLUSIONS: Surgery could represent a useful adjunct to chemotherapy in the management of @entity4 -resistant recurrent @entity2 @entity0 , carefully selected, in highly selected centers. Larger prospective trials are needed to further confirm our experience.

title: Secondary Cytoreduction in @entity4 -Resistant Recurrent XXXX : A Single-Institution Experience.

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to observe the role of secondary cytoreductive surgery in @entity4 -resistant recurrent @entity2 ( @entity2 ) @entity0 . METHODS: We collected data of @entity0 affected by recurrent @entity2 treated between 1995 and 2013. Inclusion criteria were: invasive epithelial @entity2 histologically documented, cytoreductive surgery and @entity4 -based chemotherapy at first-line treat ment with evidence of complete response to treatment, disease-free interval <6  months, and no concomitant @entity1 . @entity0 considered susceptible of cytoreductive surgery (group A) were compared with a historical series of @entity0 with similar characteristics but not eligible for surgery (group B). RESULTS: Of 122 @entity4 -resistant @entity0 , 18 met the inclusion criteria for the study and were enrolled. They were compared with a historical series of 18 @entity0 not surgically treated with analogous clinical and pathological features. The most frequent sites of relapse included pelvic and aortic lymph nodes (39  %), peritoneum (33  %), bowel (28  %), and pelvis (22  %). A low rate of @entity3 was reported. No deaths were recorded. Overall survival was significantly longer in cytoreductive group when compared with the control group (P  =  0.035). Median overall survival was 44  months. Estimated 5-year overall survival rates were 57 versus 23.5  % for groups A and B, respectively. CONCLUSIONS: Surgery could represent a useful adjunct to chemotherapy in the management of @entity4 -resistant recurrent @entity2 @entity0 , carefully selected, in highly selected centers. Larger prospective trials are needed to further confirm our experience.

title: Secondary Cytoreduction in XXXX -Resistant Recurrent @entity2 : A Single-Institution Experience.

answer: @entity4


abstract: OBJECTIVE: In the medical literature, @entity2 has traditionally been considered a rare occurrence. We hypothesise that the incidence of such protrusions and their abdominal symptoms is higher than is generally believed and that their presence may account for a significant proportion of chronic @entity1 . Accordingly, the present study was designed to identify and quantify the symptoms experienced by @entity0 with @entity2 and to assess the relative risk of these symptoms being presented, compared to the general population. DESIGN: We conducted a cross-sectional study with a control group. The following comparison groups were analysed: case group, consisting of 100 @entity0 diagnosed with @entity2 in our hospital between February 2007 and October 2012, and control group consisting of 100 subjects from the general population, chosen at random. To compare the symptoms observed in each group, the following tests were applied to all study subjects: clinical examination, gastrointestinal-related quality of life (GIQLI) questionnaire and DN4 questionnaire. We also reviewed the subjects' medical records for the previous 3  years. RESULTS: The subjects in the case group had a significantly higher incidence of digestive-urologic symptoms, a poorer gastrointestinal quality of life and greater need of medical care than those in the control group. The differences were statistically significant for all the parameters studied. Almost all the case group subjects suffered chronic @entity1 and/or digestive-urologic symptoms. We term this group of symptoms "chronic @entity3 ". Nevertheless, in most cases, no neurologic aetiology was suspected, and therefore the treatment given was ineffective. In view of the results obtained, we propose a diagnostic-therapeutic algorithm for such @entity0 . CONCLUSION: @entity2 disc protrusion, as well as having a non-negligible incidence, is often associated with a digestive-urologic clinical syndrome, and this factor should be taken into account in all cases of chronic @entity1 and other digestive-urologic symptoms when standard tests are negative, so that appropriate treatment may be given.

title: XXXX . Study of 100 cases and proposed diagnostic-therapeutic algorithm.

answer: @entity3


abstract: In transplantation studies of Rauscher leukemic SJL/J @entity0 longer @entity2 ( @entity2 ) were obtained with spleen cells from syngeneic donors than with marrow. These could be further extended by immunization of the donors to Rauscher virus (RLV) and @entity3 cells. This suggests that spleen cells exert a greater graft-vs- @entity3 effect than marrow. Nevertheless, with syngeneic cells all recipients eventually died of @entity3 relapse. In contrast, the use of RLV-resistant C57BL/10J allogeneic marrow cells resulted in a substantial number of long-term survivors and a low incidence of @entity1 , while the use of pure allogeneic spleen cells resulted in early and fatal GvH response in all recipients. To determine if allogeneic spleen cells might have any demonstrably beneficial effect on survival of leukemic @entity0 various small quantities of C57BL/10J spleen cells were mixed with marrow from the same donors and engrafted into normal and leukemic SJL/J recipients. Among the normal @entity0 @entity2 decreased as a function of spleen cell concentration. However, with the leukemics the use of 2.5 or 5% spleen cells resulted in later deaths than that found when leukemic @entity0 were given only marrow. Also, for all allogeneic spleen/marrow mixtures tested, survival of leukemic recipients exceeded that of normal recipients given the same cell mixtures. These data suggest a possible beneficial effect of small amounts of allogeneic spleen cells in transplantation therapy for @entity3 , and a possible competitive interaction of anti-host and anti-leukemic activities of the transplanted cells leading to a moderation of the GvH response.

title: @entity3 and moderation of graft-vs-host reaction in transplantation therapy of XXXX .

answer: @entity3


abstract: In transplantation studies of Rauscher leukemic SJL/J @entity0 longer @entity2 ( @entity2 ) were obtained with spleen cells from syngeneic donors than with marrow. These could be further extended by immunization of the donors to Rauscher virus (RLV) and @entity3 cells. This suggests that spleen cells exert a greater graft-vs- @entity3 effect than marrow. Nevertheless, with syngeneic cells all recipients eventually died of @entity3 relapse. In contrast, the use of RLV-resistant C57BL/10J allogeneic marrow cells resulted in a substantial number of long-term survivors and a low incidence of @entity1 , while the use of pure allogeneic spleen cells resulted in early and fatal GvH response in all recipients. To determine if allogeneic spleen cells might have any demonstrably beneficial effect on survival of leukemic @entity0 various small quantities of C57BL/10J spleen cells were mixed with marrow from the same donors and engrafted into normal and leukemic SJL/J recipients. Among the normal @entity0 @entity2 decreased as a function of spleen cell concentration. However, with the leukemics the use of 2.5 or 5% spleen cells resulted in later deaths than that found when leukemic @entity0 were given only marrow. Also, for all allogeneic spleen/marrow mixtures tested, survival of leukemic recipients exceeded that of normal recipients given the same cell mixtures. These data suggest a possible beneficial effect of small amounts of allogeneic spleen cells in transplantation therapy for @entity3 , and a possible competitive interaction of anti-host and anti-leukemic activities of the transplanted cells leading to a moderation of the GvH response.

title: XXXX and moderation of graft-vs-host reaction in transplantation therapy of @entity3 .

answer: @entity3


abstract: @entity3 @entity1 group (Lcs) consists of three phylogenetically closely related species ( @entity1 , @entity2 , and @entity3 ), which are widely used in the dairy and probiotic industrial sectors. Strategies to easily and rapidly characterize Lcs are therefore of interest. To this aim, we developed a method according to a technique known as @entity0 ( @entity0 ), which was applied to a 150bp groEL gene fragment. The analysis was performed on 53 Lcs strains and 29 strains representatives of species that are commonly present in dairy and probiotic products and can be most probably co-isolated with Lcs strains. DNA amplification was obtained only from Lcs strains, demonstrating the specificity of the groEL primers designed in this study. The @entity0 clustered Lcs strains in three groups that exactly corresponded to the species of the @entity1 group. A following @entity0 separated the 39 @entity2 strains in two well distinct intraspecific groups, indicating the possible existence of at least two distinct genotypes inside the species. Nonetheless, the phenotypic characterization demonstrated that the genotypes do not correspond to the two @entity2 , namely paracasei and tolerans. In conclusion, the melting curve analysis developed in this study is demonstrably a simple, labor-saving, and rapid strategy obtain the genotyping of a bacterial isolate and simultaneously potentially confirm its affiliation to the @entity1 group of species. The application of this method to a larger collection of strains may validate the possibility to use the proposed @entity0 protocol for the taxonomic discrimination of @entity1 group of species. In general, this study suggests that @entity0 can be a suitable technique for the genetic typization of @entity3 strains.

title: Melting curve analysis of a groEL PCR fragment for the rapid genotyping of strains belonging to the @entity3 XXXX group of species.

answer: @entity1


abstract: @entity3 @entity1 group (Lcs) consists of three phylogenetically closely related species ( @entity1 , @entity2 , and @entity3 ), which are widely used in the dairy and probiotic industrial sectors. Strategies to easily and rapidly characterize Lcs are therefore of interest. To this aim, we developed a method according to a technique known as @entity0 ( @entity0 ), which was applied to a 150bp groEL gene fragment. The analysis was performed on 53 Lcs strains and 29 strains representatives of species that are commonly present in dairy and probiotic products and can be most probably co-isolated with Lcs strains. DNA amplification was obtained only from Lcs strains, demonstrating the specificity of the groEL primers designed in this study. The @entity0 clustered Lcs strains in three groups that exactly corresponded to the species of the @entity1 group. A following @entity0 separated the 39 @entity2 strains in two well distinct intraspecific groups, indicating the possible existence of at least two distinct genotypes inside the species. Nonetheless, the phenotypic characterization demonstrated that the genotypes do not correspond to the two @entity2 , namely paracasei and tolerans. In conclusion, the melting curve analysis developed in this study is demonstrably a simple, labor-saving, and rapid strategy obtain the genotyping of a bacterial isolate and simultaneously potentially confirm its affiliation to the @entity1 group of species. The application of this method to a larger collection of strains may validate the possibility to use the proposed @entity0 protocol for the taxonomic discrimination of @entity1 group of species. In general, this study suggests that @entity0 can be a suitable technique for the genetic typization of @entity3 strains.

title: Melting curve analysis of a groEL PCR fragment for the rapid genotyping of strains belonging to the XXXX @entity1 group of species.

answer: @entity3


abstract: BACKGROUND: Optimal management of @entity1 ( @entity1 ) remains unclear. OBJECTIVE: To evaluate diagnostic yields and downstream clinical outcomes comparing video capsule endoscopy (VCE) with push enteroscopy (PE). METHODS: @entity0 with @entity1 and negative esophagogastroduodenoscopies and colonoscopies were randomly assigned to VCE or PE and followed for 12 months. End points included diagnostic yield, @entity2 , health resource utilization and crossovers. RESULTS: Data from 79 @entity0 were analyzed (VCE n=40; PE n=39; 82.3% overt @entity1 ). VCE had greater diagnostic yield (72.5% versus 48.7%; P<0.05), especially in the distal small bowel (58% versus 13%; P<0.01). More VCE-identified lesions were rated possible or certain causes of @entity2 (79.3% versus 35.0%; P<0.05). During follow-up, there were no differences in the rates of ongoing @entity2 (acute [40.0% versus 38.5%; P not significant], chronic [32.5% versus 45.6%; P not significant]), nor in health resource utilization. Fewer VCE-first @entity0 crossed over due to ongoing @entity2 (22.5% versus 48.7%; P<0.05). CONCLUSIONS: A VCE-first approach had a significant diagnostic advantage over PE-first in @entity0 with @entity1 , especially with regard to detecting small bowel lesions, affecting clinical certainty and subsequent further small bowel investigations, with no subsequent differences in @entity2 or resource utilization outcomes in follow-up. These findings question the clinical relevance of many of the discovered endoscopic lesions or the ability to treat most of these effectively over time. Improved prognostication of both @entity0 characteristics and endoscopic lesion appearance with regard to @entity2 behaviour, coupled with the impact of therapeutic deep enteroscopy, is now required using adapted, high-quality study methodologies.

title: Randomized controlled trial comparing outcomes of video capsule endoscopy with push enteroscopy in XXXX .

answer: @entity1


abstract: BACKGROUND: The role of technology in health care delivery has grown rapidly in the last decade. The potential of mobile telehealth (MTH) to support @entity0 self-management is a key area of research. Providing @entity0 with technological tools that allow for the recording and transmission of health parameters to health care professionals (HCPs) may promote behavior changes that result in improved health outcomes. Although for some conditions the evidence of the effectiveness of MTH is clear, to date the findings on the effects of MTH on @entity1 management remain inconsistent. OBJECTIVE: This study aims to evaluate an MTH intervention among @entity2 -requiring adults with @entity1 to establish whether supplementing standard care with MTH results in improved health outcomes-glycated hemoglobin (HbA1c), blood pressure (BP), health-related quality of life (HRQoL), @entity1 self-management behaviors, @entity1 health care utilization, and @entity1 self-efficacy and illness beliefs. An additional objective was to explore the acceptability of MTH and @entity0 ' perceptions of, and experience, using it. METHODS: A mixed-method design consisting of a 9-month, two-arm, parallel randomized controlled trial (RCT) was used in combination with exit qualitative interviews. Quantitative data was collected at baseline, 3 months, and 9 months. Additional intervention fidelity data, such as @entity0 ' MTH transmissions and contacts with the MTH nurse during the study, were also recorded. RESULTS: Data collection for both the quantitative and qualitative components of this study has ended and data analysis is ongoing. A total of 86 @entity0 were enrolled into the study. Out of 86 @entity0 , 45 (52%) were randomized to the intervention group and 36 (42%) to the control group. Preliminary data on MTH training sessions and MTH usage by intervention @entity0 are presented in this paper. We expect to publish complete study results in 2015. CONCLUSIONS: The range of data collected in this study will allow for a comprehensive evaluation of processes and outcomes. The early results presented suggest that MTH usage decreases over time and that MTH @entity0 would benefit from attending more than one training session. TRIAL REGISTRATION: ClinicalTrials.gov NCT00922376; http://clinicaltrials.gov/ct2/show/NCT00922376 (Archived by WebCite at http://www.webcitation.org/6Vu4nhLI6).

title: A Mobile Telehealth Intervention for Adults With @entity2 -Requiring XXXX : Early Results of a Mixed-Methods Randomized Controlled Trial.

answer: @entity1


abstract: BACKGROUND: The role of technology in health care delivery has grown rapidly in the last decade. The potential of mobile telehealth (MTH) to support @entity0 self-management is a key area of research. Providing @entity0 with technological tools that allow for the recording and transmission of health parameters to health care professionals (HCPs) may promote behavior changes that result in improved health outcomes. Although for some conditions the evidence of the effectiveness of MTH is clear, to date the findings on the effects of MTH on @entity1 management remain inconsistent. OBJECTIVE: This study aims to evaluate an MTH intervention among @entity2 -requiring adults with @entity1 to establish whether supplementing standard care with MTH results in improved health outcomes-glycated hemoglobin (HbA1c), blood pressure (BP), health-related quality of life (HRQoL), @entity1 self-management behaviors, @entity1 health care utilization, and @entity1 self-efficacy and illness beliefs. An additional objective was to explore the acceptability of MTH and @entity0 ' perceptions of, and experience, using it. METHODS: A mixed-method design consisting of a 9-month, two-arm, parallel randomized controlled trial (RCT) was used in combination with exit qualitative interviews. Quantitative data was collected at baseline, 3 months, and 9 months. Additional intervention fidelity data, such as @entity0 ' MTH transmissions and contacts with the MTH nurse during the study, were also recorded. RESULTS: Data collection for both the quantitative and qualitative components of this study has ended and data analysis is ongoing. A total of 86 @entity0 were enrolled into the study. Out of 86 @entity0 , 45 (52%) were randomized to the intervention group and 36 (42%) to the control group. Preliminary data on MTH training sessions and MTH usage by intervention @entity0 are presented in this paper. We expect to publish complete study results in 2015. CONCLUSIONS: The range of data collected in this study will allow for a comprehensive evaluation of processes and outcomes. The early results presented suggest that MTH usage decreases over time and that MTH @entity0 would benefit from attending more than one training session. TRIAL REGISTRATION: ClinicalTrials.gov NCT00922376; http://clinicaltrials.gov/ct2/show/NCT00922376 (Archived by WebCite at http://www.webcitation.org/6Vu4nhLI6).

title: A Mobile Telehealth Intervention for Adults With XXXX -Requiring @entity1 : Early Results of a Mixed-Methods Randomized Controlled Trial.

answer: @entity2


abstract: The difficulties in assessing the teratogenic potential of drugs used during pregnancy have been made evident by experiences with @entity5 and @entity7 ( @entity8 ). In the case of @entity5 , the drug's ability to cause @entity6 tended to be species specific, and thus animal studies were unreliable indicators of teratogenicity in @entity0 . With DES, the delayed appearance of injury, almost a generation after birth, indicates that short-term studies may fail to reveal serious effects. In both cases only the otherwise rare occurrence of the condition led to the suspicion of a cause-and-effect relationship. Although wide-spread use of drugs such as LSD, heroin, and marijuana has necessitated assessment of their teratogenic potential, a controlled investigation of their effects has so far been impossible to conduct. Both @entity3 and @entity2 have been associated with adverse effects on the fetus and neonate, but the precise mechanisms by which these effects occur are as yet unclear. There is also reason for concern about the teratogenic potential of environmental pollutants such as organic @entity4 compounds, lead, and radiation. Furthermore, the fetus may potentially be harmed if a particular drug is not administered (eg, insulin for @entity1 during pregnancy). In the final analysis, any potential benefits of therapy for the mother must be weighed against known and unknown risks to the @entity0 . Rational management requires an understanding of the physiologic and pharmacologic principles involved in each case and careful and judicious selection of drug therapy.

title: In vivo assessment of the teratogenic potential of drugs in XXXX .

answer: @entity0


abstract: UNASSIGNED: Prescription opioid and @entity4 have been increasing steadily year after year, and continue to be a serious national problem. A sequela of the increase in @entity2 has been an increase in the number of @entity0 born with @entity2 . These @entity0 often require costly, prolonged stays in the neonatal intensive care unit (NICU) for drug withdrawal treatment. The authors studied a population of @entity0 from a large Medicaid health plan who were born with @entity3 ( @entity3 ) secondary to in utero opioid exposure to assess the average length of stay in the NICU, and to determine the variables that may account for differences in interinstitutional lengths of stay. The overall average length of stay for @entity3 was 21.1 days for the 139 @entity0 included in the study. Analysis of the medication used for treatment revealed that @entity0 who were treated with a combined inpatient/outpatient regimen with @entity1 had an average length of stay of 11.4 days versus 25.1 days for @entity0 who were treated entirely as inpatients (P<0.001), a 55% reduction in average length of stay. In 2009 there were an estimated 13,600 cases of @entity3 in the United States at a cost of  53,000 per case. A 55% reduction in length of stay corresponds to  396 million in annual savings for the treatment of @entity3 . Development of successful combined inpatient/outpatient management programs for @entity3 warrants further consideration. (Population Health Management 2015;18:392-397).

title: XXXX : Influence of a Combined Inpatient/Outpatient @entity1 Treatment Regimen on the Average Length of Stay of a Medicaid NICU Population.

answer: @entity3


abstract: UNASSIGNED: Prescription opioid and @entity4 have been increasing steadily year after year, and continue to be a serious national problem. A sequela of the increase in @entity2 has been an increase in the number of @entity0 born with @entity2 . These @entity0 often require costly, prolonged stays in the neonatal intensive care unit (NICU) for drug withdrawal treatment. The authors studied a population of @entity0 from a large Medicaid health plan who were born with @entity3 ( @entity3 ) secondary to in utero opioid exposure to assess the average length of stay in the NICU, and to determine the variables that may account for differences in interinstitutional lengths of stay. The overall average length of stay for @entity3 was 21.1 days for the 139 @entity0 included in the study. Analysis of the medication used for treatment revealed that @entity0 who were treated with a combined inpatient/outpatient regimen with @entity1 had an average length of stay of 11.4 days versus 25.1 days for @entity0 who were treated entirely as inpatients (P<0.001), a 55% reduction in average length of stay. In 2009 there were an estimated 13,600 cases of @entity3 in the United States at a cost of  53,000 per case. A 55% reduction in length of stay corresponds to  396 million in annual savings for the treatment of @entity3 . Development of successful combined inpatient/outpatient management programs for @entity3 warrants further consideration. (Population Health Management 2015;18:392-397).

title: @entity3 : Influence of a Combined Inpatient/Outpatient XXXX Treatment Regimen on the Average Length of Stay of a Medicaid NICU Population.

answer: @entity1


abstract: PURPOSE: @entity3 ( @entity3 ) is a transitory, short-lasting @entity1 characterized by a sudden onset of antero- and retrograde @entity2 . Perfusion abnormalities in @entity3 have been evaluated mainly by use of positron emission tomography (PET) or single-photon emission computed tomography (SPECT). In the present study we explore the value of dynamic susceptibility contrast perfusion-weighted MRI (PWI) in @entity3 in the acute phase. METHODS: From a MRI report database we identified @entity3 @entity0 who underwent MRI including PWI in the acute phase and compared these to control subjects. Quantitative perfusion maps (cerebral blood flow (CBF) and volume (CBV)) were generated and analyzed by use of Signal Processing In NMR-Software (SPIN). CBF and CBV values in subcortical brain regions were assessed by use of VOI created in FIRST, a model-based segmentation tool in the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL). RESULTS: Five @entity3 @entity0 were included (2 @entity0 , 3 @entity0 ). On PWI, no relevant perfusion alterations were found by visual inspection in @entity3 @entity0 . Group comparisons for possible differences between @entity3 @entity0 and control subjects showed significant lower rCBF values bilaterally in the hippocampus, in the left thalamus and globus pallidus as well as bilaterally in the putamen and the left caudate nucleus. Correspondingly, significant lower rCBV values were observed bilaterally in the hippocampus and the putamen as well as in the left caudate nucleus. Group comparisons for possible side differences in rCBF and rCBV values in @entity3 @entity0 revealed a significant lower rCBV value in the left caudate nucleus. CONCLUSIONS: Mere visual inspection of PWI is not sufficient for the assessment of perfusion changes in @entity3 in the acute phase. Group comparisons with healthy control subjects might be useful to detect subtle perfusion changes on PWI in @entity3 @entity0 . However, this should be confirmed in larger data sets and serial PWI examinations.

title: Value of Dynamic Susceptibility Contrast Perfusion MRI in the Acute Phase of Transient XXXX .

answer: @entity2


abstract: BACKGROUND: In case of a loss of response to adalimumab, some @entity0 with @entity1 may derive benefit from increasing the dosing frequency to 40 mg weekly. Efficacy and safety of adalimumab 80 mg weekly remain unknown. METHODS: From February 2011 to September 2012, all adults who had active @entity1 , defined at least by @entity1 activity index >150 and 1 objective sign of @entity2 , and required an adalimumab dose escalation to 80 mg weekly were enrolled in a prospective multicenter cohort study. @entity1 activity index and @entity4 levels were recorded during the first 14 weeks following adalimumab optimization and at 6 months. All adverse events were recorded. RESULTS: Forty-two @entity0 were included. The median age was 33 years, and the median disease duration was 8.6 years. Adalimumab was associated with @entity3 in 28% of cases and with immunomodulators in 10% of @entity0 . Within the 14 weeks after adalimumab optimization, 14 @entity0 (33.3%) achieved clinical remission ( @entity1 activity index <150), and 23 @entity0 (54.8%) had a clinical response. Clinical improvement was associated with a drop in the @entity4 level from 18 to 5 mg/L (P = 0.0008). After a median follow-up of 14.5 months, 5 @entity0 underwent major abdominal surgery. Adverse events were reported in 13 @entity0 (31%). CONCLUSIONS: Adalimumab 80 mg weekly seems to be well-tolerated and may be effective in inducing clinical remission in @entity0 with luminal @entity1 who failed to respond to 40 mg weekly or 80 mg every other week.

title: Efficacy and Safety of Adalimumab 80 mg Weekly in Luminal XXXX .

answer: @entity1


abstract: The relative fibrinogenolytic, fibrinolytic and thrombolytic properties of @entity0 @entity2 and @entity0 urokinase were compared in purified systems, in whole @entity0 plasma and in a system composed of a radioactive @entity0 blood clot (125I-fibrinogen) hanging in circulating @entity0 plasma. The @entity0 @entity2 was highly purified from the culture fluid of a @entity0 @entity1 cell line. In purified systems composed of fibrinogen of fibrin, plasminogen and alpha 2-antiplasmin as well as in whole plasma, @entity2 digested fibrin without degrading fibrinogen significantly. Urokinase did not have this specific fibrinolytic effect. In the circulating plasma system, the degree of fibrinolysis was proportional to the amount of activator added, @entity2 being about 10 times more efficient than urokinase. In addition, @entity2 appeared to cause negligible fibrinogen degradation. @entity2 still induced significant thrombolysis at a concentration of 10 IU per ml whereas no effect of urokinase was observed at 20 IU per ml. Infusion of 100 IU (1 microgram) of @entity2 per ml resulted in moderate activation of the fibrinolytic system as judged from a decrease of plasminogen and alpha 2-antiplasmin to 40-50 percent. Nevertheless, extensive fibrinolysis (50 to 80 percent of radioactivity released after 12 hrs) and only very limited fibrinogenolysis were observed. An equivalent amount of urokinase (100 IU per ml) only induced approximately 15 percent lysis in 12 hrs. At higher concentrations of urokinase (260 IU per ml or more) extensive activation of the fibrinolytic system was obtained as evidenced by a depletion of plasminogen, alpha 2-antiplasmin and fibrinogen. This was associated with extensive fibrinolysis (approximately 60 percent after 12 hrs). It is concluded that @entity0 @entity2 is a more specific and effective fibrinolytic-thrombolytic agent than @entity0 urokinase.

title: Comparison of the relative fibrinogenolytic, fibrinolytic and thrombolytic properties of XXXX and urokinase in vitro.

answer: @entity2


abstract: The role of DNA repair genes (uvrA, uvrB, uvrD, recA, recB, @entity2 , and umuC) in spontaneous mutation rate per bacterium per cell division (micro) was determined for the reversion of UAA (his-4 and trpE65), UAG (lacZ53), and frameshift (trpE9777) mutations, and for the occurrence of forward mutations to @entity1 resistance. Rich growth medium enhanced micro in a wildtype strain but not in a uvrB5 strain. In minimal growth medium, the uvrA and uvrB strains had the largest micro (1.9-6.2-fold greater than that for isogenic wild-type strains, depending on the mutation assay). The uvrB strains carrying @entity2 , recA, umuC, or both the uvrD and rec B mutations (in combination), i.e., mutations that inhibit error-prone DNA repair, had the lowest micro values (approximately 10-fold less than the uvrB strain). Teh recA and @entity2 mutations also reduced micro (by approximately 2-fold) in uvr+ strains. The genetic control of the error prone repair-dependent sector of spontaneous mutagenesis was shown to be qualitatively similar to the genetic control for u.v. radiation mutagenesis. The umuC mutation, which drastically reduced spontaneous mutagensis, had no effect on genetic recombination. It is proposed that the low level of spontaneous mutagenesis observed in the recA, @entity2 , umuC, and the uvrD recB strains is due to errors made during DNA replication, while the enhanced level of spontaneous mutagenesis observed in the wild type, and especially in the uvrA and uvrB strains, is due to excisable lesions that are produced in the DNA by normal metabolic reactions, and that such unexcised lesions induce mutations via error-prone DNA repair. These results are discussed in terms of their relevance to spontaneous @entity0 .

title: Much of spontaneous mutagenesis in Escherichia coli is due to error-prone DNA repair: implications for spontaneous XXXX .

answer: @entity0


abstract: This study was carried out to find the prevalence of precipitin reactions in the sera of 200 North American @entity2 subjects. Precipitins were detected by the double diffusion technique using different extracts of @entity1 , including a reference 'home produced' extract and five commercial extracts from three different suppliers. In addition, antigenicity of these extracts was assessed by crossed immunoelectrophoresis (XIE). Of the sera, 13.5% reacted to the reference extract and from 2.5 to 12% to the different commercial extracts; 22.5% of the sera reacted to at least one extract. No one serum reacted to all the extracts. Two of fifty-one (4%) nonatopic @entity0 with a negative immediate prick test to A. fumigatus, six of eighty-seven (6.9%) @entity3 @entity0 with a negative immediate reaction to A. fumigatus, and thirty-seven of sixty two (59%) @entity3 @entity0 with a positive immediate reaction to A. fumigatus had precipitins to at least one of the extracts used, the skin tests being performed using the A. fumigatus reference extract. The prevalence of precipitin reactions bore a strong correlation with the antigenicity of the extracts by XIE. The same reference extract was also used for specific IgE measurements (Brompton extract, Malo _ Paquin, 1979). It was found that @entity0 with precipitins had significantly (P less than 0.001) higher specific and total IgE values than @entity0 without precipitins. In the group of @entity0 with positive skin test, those with precipitins had significantly (P less than 0.05) higher specific IgE values than those without. The authors conclude that different extracts of A. fumigatus should be used to assess the presence of precipitins. The antigenicity of these extracts should also be assayed.

title: Prevalence of precipitating antibodies to different extracts of XXXX in a North American @entity2 population.

answer: @entity1


abstract: This study was carried out to find the prevalence of precipitin reactions in the sera of 200 North American @entity2 subjects. Precipitins were detected by the double diffusion technique using different extracts of @entity1 , including a reference 'home produced' extract and five commercial extracts from three different suppliers. In addition, antigenicity of these extracts was assessed by crossed immunoelectrophoresis (XIE). Of the sera, 13.5% reacted to the reference extract and from 2.5 to 12% to the different commercial extracts; 22.5% of the sera reacted to at least one extract. No one serum reacted to all the extracts. Two of fifty-one (4%) nonatopic @entity0 with a negative immediate prick test to A. fumigatus, six of eighty-seven (6.9%) @entity3 @entity0 with a negative immediate reaction to A. fumigatus, and thirty-seven of sixty two (59%) @entity3 @entity0 with a positive immediate reaction to A. fumigatus had precipitins to at least one of the extracts used, the skin tests being performed using the A. fumigatus reference extract. The prevalence of precipitin reactions bore a strong correlation with the antigenicity of the extracts by XIE. The same reference extract was also used for specific IgE measurements (Brompton extract, Malo _ Paquin, 1979). It was found that @entity0 with precipitins had significantly (P less than 0.001) higher specific and total IgE values than @entity0 without precipitins. In the group of @entity0 with positive skin test, those with precipitins had significantly (P less than 0.05) higher specific IgE values than those without. The authors conclude that different extracts of A. fumigatus should be used to assess the presence of precipitins. The antigenicity of these extracts should also be assayed.

title: Prevalence of precipitating antibodies to different extracts of @entity1 in a North American XXXX population.

answer: @entity2


abstract: A study is reported of @entity0 receiving 180 renal allotransplants and at risk for 1 or more years who had pretransplant and posttransplant skin tests using @entity2 ( @entity2 ) recall antigens. Pretransplant skin testing revealed an incidence of 14% anergic @entity0 prior to a first transplant, and 35% were anergic prior to a second allograft. There was a statistically significant correlation between pretransplant anergy and age, as well as a significant correlation between pretransplant anergy and time of dialysis-dependent @entity5 . The conversion to the anegic state posttransplant in those @entity0 with surviving allografts increased annually for the first 5 years as a linear function, with 69% of the population at risk with their first transplant exhibiting anergy by 5 years. In those @entity0 receiving second renal transplants, all were anergic by 4 years posttransplant. In vitro tests of lymphocyte function using mitogen stimulation did not reveal significant differences between anergic and responsive @entity0 . In this series of 180 allografts there were 14 late deaths. Eleven of these were in anergic @entity0 and in 10 instances were related to @entity4 or @entity1 . Three @entity0 who were skin-test responsive at the time of @entity3 died from cardiovascular causes. It is concluded that there is an increasing risk of the development of anergy to @entity2 antigens posttransplant and that the type of late mortality may be marked by this hyporeactive state.

title: Development of anergy to XXXX antigens following renal allotransplantation.

answer: @entity2


abstract: This study was to examine the effects of @entity2 in @entity1 @entity0 undergoing @entity4 . A quasiexperimental study design was used. @entity0 were evaluated at five time points: before treatment (T1) and 2, 3, 4, and 5 days after treating @entity4 (T2, T3, T4, and T5). Fatigue and @entity2 were assessed by a VAS @entity3 scale and a VAS @entity2 scale at each time point. TFRS and BDI were administered at T1 and T5. @entity0 ' @entity3 and @entity2 were significantly higher at T5 than at T1 in two groups. Fatigue and @entity2 increased in both the experimental and control groups' @entity0 over the five days of hospitalization during which @entity4 and chemotherapy were administered. The experimental group had significantly less @entity3 than the control group, with lower subscale scores on physical, psychosocial, daily, and overall @entity3 . There were no differences between the groups on @entity2 . At posttest, the experimental group experienced lower physical, psychosocial, daily, and overall @entity3 than the control group. Acupressure can improve @entity3 in @entity1 @entity0 during treatment with @entity4 but did not alleviate @entity2 . Discharge planning should include home care for management of @entity3 and @entity2 .

title: Effects of acupressure on fatigue and XXXX @entity0 treated with transcatheter arterial chemoembolization: a quasi-experimental study.

answer: @entity1


abstract: This study was to examine the effects of @entity2 in @entity1 @entity0 undergoing @entity4 . A quasiexperimental study design was used. @entity0 were evaluated at five time points: before treatment (T1) and 2, 3, 4, and 5 days after treating @entity4 (T2, T3, T4, and T5). Fatigue and @entity2 were assessed by a VAS @entity3 scale and a VAS @entity2 scale at each time point. TFRS and BDI were administered at T1 and T5. @entity0 ' @entity3 and @entity2 were significantly higher at T5 than at T1 in two groups. Fatigue and @entity2 increased in both the experimental and control groups' @entity0 over the five days of hospitalization during which @entity4 and chemotherapy were administered. The experimental group had significantly less @entity3 than the control group, with lower subscale scores on physical, psychosocial, daily, and overall @entity3 . There were no differences between the groups on @entity2 . At posttest, the experimental group experienced lower physical, psychosocial, daily, and overall @entity3 than the control group. Acupressure can improve @entity3 in @entity1 @entity0 during treatment with @entity4 but did not alleviate @entity2 . Discharge planning should include home care for management of @entity3 and @entity2 .

title: Effects of acupressure on fatigue and @entity1 XXXX treated with transcatheter arterial chemoembolization: a quasi-experimental study.

answer: @entity0


abstract: BACKGROUND: @entity2 ( @entity2 ) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as @entity3 have been explored. METHODS: A detailed retrospective analysis was performed according to data collected from 13 @entity0 with @entity2 . At the time of @entity2 diagnosis, immunosuppressive therapy was decreased and @entity3 administered. Overall survival, disease-free survival of @entity0 and graft survival were determined. RESULTS: Among 590 kidney transplant recipients, 13 adult @entity0 with @entity2 were included in this study. The mean age of the @entity0 was 42.15 (range: 25-58) years at the time of @entity2 diagnosis, and 9 @entity0 were male. Histology was distributed in 9 diffuse large B cell, 1 @entity1 , 1 @entity2 . The response rate to @entity3 alone was 30.8%. The mean overall survival period was 23.38 months and 11 @entity0 are still alive. In total, 10 @entity0 (76.9%) achieved a complete remission with functioning graft in 11 (84.6%) @entity0 . CONCLUSION: Despite the retrospective focus and limited number of @entity0 , this study provides promising results regarding the effectiveness of stopping calcineurin inhibitors and switching to @entity3 for @entity0 with @entity2 .

title: Outcome of @entity3 therapy for XXXX after kidney transplantation: case series.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as @entity3 have been explored. METHODS: A detailed retrospective analysis was performed according to data collected from 13 @entity0 with @entity2 . At the time of @entity2 diagnosis, immunosuppressive therapy was decreased and @entity3 administered. Overall survival, disease-free survival of @entity0 and graft survival were determined. RESULTS: Among 590 kidney transplant recipients, 13 adult @entity0 with @entity2 were included in this study. The mean age of the @entity0 was 42.15 (range: 25-58) years at the time of @entity2 diagnosis, and 9 @entity0 were male. Histology was distributed in 9 diffuse large B cell, 1 @entity1 , 1 @entity2 . The response rate to @entity3 alone was 30.8%. The mean overall survival period was 23.38 months and 11 @entity0 are still alive. In total, 10 @entity0 (76.9%) achieved a complete remission with functioning graft in 11 (84.6%) @entity0 . CONCLUSION: Despite the retrospective focus and limited number of @entity0 , this study provides promising results regarding the effectiveness of stopping calcineurin inhibitors and switching to @entity3 for @entity0 with @entity2 .

title: Outcome of XXXX therapy for @entity2 after kidney transplantation: case series.

answer: @entity3


abstract: The ability to predict protein function from structure is becoming increasingly important; hence, elucidation and determination of protein structure become the major steps in proteomics. The present study was undertaken for identification of metalloprotease produced by @entity3 B80 and recognition of characteristics that can be industrially exploited. The enzyme was purified in three steps combining precipitation and chromatographic methods resulting in 33.5% recovery with 13.1-fold purification of enzyme which was detected as a single band with a molecular mass of 26   kDa approximately in @entity0 -PAGE and zymogram. The @entity1 showed that the enzyme exhibited 70-93% similarity with @entity2 metalloproteases from various strains Bacillus sp. specifically from @entity3 group. The sequence alignment revealed the presence of @entity2 -binding region VVVHEMCHMV in the most conserved C terminus region. Secondary structure of the enzyme was obtained by CD spectra and I-TASSER. The enzyme kinetics revealed a Michaelis constant (K m ) of 0.140    mol/ml and V max of 2.11    mol/min. The application studies showed that the enzyme was able to hydrolyze various proteins with highest affinity towards casein followed by BSA and gelatin. The enzyme exhibited strong fibrinolytic, collagenolytic, and gelatinolytic properties and stability in various organic solvents.

title: XXXX and CD Spectral Analysis for Identification and Structure Prediction of a Purified, Novel, Organic Solvent Stable, Fibrinolytic Metalloprotease from @entity3 B80.

answer: @entity1


abstract: The ability to predict protein function from structure is becoming increasingly important; hence, elucidation and determination of protein structure become the major steps in proteomics. The present study was undertaken for identification of metalloprotease produced by @entity3 B80 and recognition of characteristics that can be industrially exploited. The enzyme was purified in three steps combining precipitation and chromatographic methods resulting in 33.5% recovery with 13.1-fold purification of enzyme which was detected as a single band with a molecular mass of 26   kDa approximately in @entity0 -PAGE and zymogram. The @entity1 showed that the enzyme exhibited 70-93% similarity with @entity2 metalloproteases from various strains Bacillus sp. specifically from @entity3 group. The sequence alignment revealed the presence of @entity2 -binding region VVVHEMCHMV in the most conserved C terminus region. Secondary structure of the enzyme was obtained by CD spectra and I-TASSER. The enzyme kinetics revealed a Michaelis constant (K m ) of 0.140    mol/ml and V max of 2.11    mol/min. The application studies showed that the enzyme was able to hydrolyze various proteins with highest affinity towards casein followed by BSA and gelatin. The enzyme exhibited strong fibrinolytic, collagenolytic, and gelatinolytic properties and stability in various organic solvents.

title: @entity1 and CD Spectral Analysis for Identification and Structure Prediction of a Purified, Novel, Organic Solvent Stable, Fibrinolytic Metalloprotease from XXXX B80.

answer: @entity3


abstract: @entity4 is an important @entity2 ( @entity2 ) causing pathogen worldwide. Due to absence of an affordable diagnostic assay, routine screening of @entity3 becomes impossible in developing countries where @entity1 rates are maximum. Treatment is given on the basis of symptoms alone which leads to spread of @entity1 . Thus, development of a rapid, sensitive, specific, and PCR based visual diagnostic assay suitable for developing countries, required for better disease management, is aimed at in present study. Endocervical swabs were collected from @entity0 visiting gynecology department of various hospitals in Delhi. In-house PCR based assay was developed and modified to visual assay using molecular beacon for end-point detection. It was evaluated against Roche AMPLICOR NG kit and rmp gene. Specificity of beacon was confirmed by competition experiments. Diagnostic test was 98.21% specific and 99.59% sensitive whereas negative and positive predicted value were 99.40% and 98.78%, respectively. We also observed that twice the concentration (2X) of premix was stable at 4  C for 4 months and dry swab samples gave concordant results with that of wet swabs. These features make the test best suitable for routine diagnosis of @entity1 in developing countries.

title: Diagnosis of XXXX Using Molecular Beacon.

answer: @entity4


abstract: OBJECTIVE: In this study, we aimed to investigate the association of @entity5 polymorphism of the b3-adrenergic receptor gene (b-3AR) with childhood @entity1 and related pathologies. METHODS: b-3AR gene @entity5 genotyping was carried out in 251 @entity0 aged 6-18 years. Of these subjects, 130 were @entity1 (62 @entity0 ) and 121 were normal-weight (53 @entity0 ). In the @entity1 group, fasting lipids, @entity2 and @entity4 levels were measured. Oral @entity2 tolerance test (OGTT) was performed in 75 of the @entity1 @entity0 . RESULTS: The frequency of @entity5 genotype was similar in @entity1 and @entity1 @entity0 . In @entity1 @entity0 , relative body mass index, waist-to-hip ratio, serum lipid, @entity2 and @entity4 levels, as well as homeostasis model assessment of @entity4 resistance (HOMA-IR) scores were not different between @entity3 allele carriers ( @entity5 and @entity6 ) and noncarriers ( @entity7 ). In 75 @entity1 @entity0 , OGTT results showed that @entity3 allele carriers had significantly higher 30-minute @entity2 levels (p=0.027). CONCLUSION: @entity5 polymorphism of the b-3AR gene is not associated with @entity1 and waist-to-hip ratio in Turkish @entity0 . Although there were no relationships between the genotypes and lipid, @entity2 / @entity4 levels or HOMA-IR, the presence of @entity5 variant seemed to have an unfavorable influence on early @entity2 excursion after @entity2 loading.

title: b-3AR @entity5 Polymorphism and 30-Minute Post-Challenge Plasma @entity2 Levels in Obese XXXX .

answer: @entity0


abstract: OBJECTIVE: In this study, we aimed to investigate the association of @entity5 polymorphism of the b3-adrenergic receptor gene (b-3AR) with childhood @entity1 and related pathologies. METHODS: b-3AR gene @entity5 genotyping was carried out in 251 @entity0 aged 6-18 years. Of these subjects, 130 were @entity1 (62 @entity0 ) and 121 were normal-weight (53 @entity0 ). In the @entity1 group, fasting lipids, @entity2 and @entity4 levels were measured. Oral @entity2 tolerance test (OGTT) was performed in 75 of the @entity1 @entity0 . RESULTS: The frequency of @entity5 genotype was similar in @entity1 and @entity1 @entity0 . In @entity1 @entity0 , relative body mass index, waist-to-hip ratio, serum lipid, @entity2 and @entity4 levels, as well as homeostasis model assessment of @entity4 resistance (HOMA-IR) scores were not different between @entity3 allele carriers ( @entity5 and @entity6 ) and noncarriers ( @entity7 ). In 75 @entity1 @entity0 , OGTT results showed that @entity3 allele carriers had significantly higher 30-minute @entity2 levels (p=0.027). CONCLUSION: @entity5 polymorphism of the b-3AR gene is not associated with @entity1 and waist-to-hip ratio in Turkish @entity0 . Although there were no relationships between the genotypes and lipid, @entity2 / @entity4 levels or HOMA-IR, the presence of @entity5 variant seemed to have an unfavorable influence on early @entity2 excursion after @entity2 loading.

title: b-3AR @entity5 Polymorphism and 30-Minute Post-Challenge Plasma XXXX Levels in Obese @entity0 .

answer: @entity2


abstract: OBJECTIVE: In this study, we aimed to investigate the association of @entity5 polymorphism of the b3-adrenergic receptor gene (b-3AR) with childhood @entity1 and related pathologies. METHODS: b-3AR gene @entity5 genotyping was carried out in 251 @entity0 aged 6-18 years. Of these subjects, 130 were @entity1 (62 @entity0 ) and 121 were normal-weight (53 @entity0 ). In the @entity1 group, fasting lipids, @entity2 and @entity4 levels were measured. Oral @entity2 tolerance test (OGTT) was performed in 75 of the @entity1 @entity0 . RESULTS: The frequency of @entity5 genotype was similar in @entity1 and @entity1 @entity0 . In @entity1 @entity0 , relative body mass index, waist-to-hip ratio, serum lipid, @entity2 and @entity4 levels, as well as homeostasis model assessment of @entity4 resistance (HOMA-IR) scores were not different between @entity3 allele carriers ( @entity5 and @entity6 ) and noncarriers ( @entity7 ). In 75 @entity1 @entity0 , OGTT results showed that @entity3 allele carriers had significantly higher 30-minute @entity2 levels (p=0.027). CONCLUSION: @entity5 polymorphism of the b-3AR gene is not associated with @entity1 and waist-to-hip ratio in Turkish @entity0 . Although there were no relationships between the genotypes and lipid, @entity2 / @entity4 levels or HOMA-IR, the presence of @entity5 variant seemed to have an unfavorable influence on early @entity2 excursion after @entity2 loading.

title: b-3AR XXXX Polymorphism and 30-Minute Post-Challenge Plasma @entity2 Levels in Obese @entity0 .

answer: @entity5


abstract: BACKGROUND: Time spent sitting is distinctly different from accumulating too little physical activity and may have independent deleterious effects. Few studies have examined the association between sitting time and site-specific @entity2 incidence. METHODS: Among 69,260 @entity1 and 77,462 @entity1 who were @entity2 -free and enrolled in the American @entity2 Society @entity2 Prevention Study II Nutrition Cohort, 18,555 @entity1 and 12,236 @entity1 were diagnosed with @entity2 between 1992 and 2009. Extended Cox proportional hazards regression was used to estimate multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI) of leisure-time spent sitting with total and site-specific @entity2 incidence. RESULTS: Longer leisure-time spent sitting, after adjustment for physical activity, BMI, and other factors, was associated with risk of total @entity2 in @entity1 (RR = 1.10; 95% CI, 1.04-1.17 for >= 6 hours vs. <3 hours per day), but not @entity1 (RR = 1.00; 95% CI, 0.96-1.05). In @entity1 , sitting time was associated with risk of @entity4 (RR = 1.65; 95% CI, 1.07-2.54), invasive @entity0 (RR = 1.10; 95% CI, 1.00-1.21), and @entity3 (RR = 1.43; 95% CI, 1.10-1.87). There were no associations between sitting time and site-specific @entity2 in @entity1 . CONCLUSION: Longer leisure-time spent sitting was associated with a higher risk of total @entity2 risk in @entity1 , and specifically with @entity4 , @entity5 , but sitting time was not associated with @entity2 risk in @entity1 . Further research is warranted to better understand the differences in associations between @entity1 and @entity1 . IMPACT: For @entity1 , these findings support American @entity2 Society guidelines for @entity2 prevention to reduce sitting time when possible.

title: Leisure-Time Spent Sitting and Site-Specific XXXX Incidence in a Large U.S. Cohort.

answer: @entity2


abstract: BACKGROUND: According to some studies, @entity3 healing is prolonged in elderly @entity0 . @entity6 in the elbow (UNE) is the second most common @entity4 . To our knowledge, no study has investigated the effect of age on the postoperative @entity5 repair rate. Our aim was to evaluate age-related differences in the electrophysiological parameters before and approximately 100  days after operations for @entity7 . METHODS: This retrospective study included 103 @entity0 who underwent in situ ulnar nerve decompressions in the elbow. The included @entity0 suffered from paraesthesia and @entity1 in their ulnar nerve distribution, @entity2 , and weakening of the hand muscles, which were innervated by the ulnar nerve. Concurrently, these @entity0 met the EGM diagnostic criteria for UNE. The age dependency on the differences between the preoperative and postoperative parameter values that were measured during the conductive studies was estimated using a regression analysis. RESULTS: A statistically significant deceleration of the monitored parameter adaptation, which included segmental conduction velocity in the elbow area and @entity8 amplitude during the above-elbow stimulation of the ulnar nerve, was found. CONCLUSIONS: @entity5 repair in the cubital tunnel area after a UNE operation proceeds significantly slower in elderly @entity0 .

title: The dependence of age on ulnar nerve conductive study parameter adaptation after XXXX operations in the elbow.

answer: @entity6


abstract: The aim of this research was the study of efficiency and endurance antihypertensive therapy on the basis of fixed combination of @entity4 and @entity2 ( @entity2 ) and @entity4 and @entity2 in combination with @entity3 according to the twenty-four-hour (? day-and-night) monitoring of blood pressure (? 24H BPM) of @entity0 with @entity1 ( @entity1 ) 2-3 severity. The study included 33 @entity0 with 2-3 grade of @entity1 (average age--54,40    3.45 years). All @entity0 performed ? 24H BPM before treatment and after 12 weeks of therapy. The combination of @entity4 and @entity2 allowed to achieve target levels of blood pressure in 79% of @entity0 , @entity3 additional purpose--in 86% of @entity0 . We found that this therapy has a corrective effect on daily blood pressure profile, significantly reducing the load pressure and blood pressure variability. During treatment with the combination of @entity4 and @entity2 combination of @entity4 , @entity2 with @entity3 optimal daily profile of blood pressure after 12 weeks of reaching respectively 63.1% and 71.4% of @entity0 . The treatment with combination of @entity4 and @entity2 and adding of @entity3 is characterized by good endurance and high adherence to treatment.

title: [Changes of twenty-four-hour profile blood pressure anad its correction of @entity0 with XXXX on the background of combined antihypertensive therapy application].

answer: @entity1


abstract: The aim of this research was the study of efficiency and endurance antihypertensive therapy on the basis of fixed combination of @entity4 and @entity2 ( @entity2 ) and @entity4 and @entity2 in combination with @entity3 according to the twenty-four-hour (? day-and-night) monitoring of blood pressure (? 24H BPM) of @entity0 with @entity1 ( @entity1 ) 2-3 severity. The study included 33 @entity0 with 2-3 grade of @entity1 (average age--54,40    3.45 years). All @entity0 performed ? 24H BPM before treatment and after 12 weeks of therapy. The combination of @entity4 and @entity2 allowed to achieve target levels of blood pressure in 79% of @entity0 , @entity3 additional purpose--in 86% of @entity0 . We found that this therapy has a corrective effect on daily blood pressure profile, significantly reducing the load pressure and blood pressure variability. During treatment with the combination of @entity4 and @entity2 combination of @entity4 , @entity2 with @entity3 optimal daily profile of blood pressure after 12 weeks of reaching respectively 63.1% and 71.4% of @entity0 . The treatment with combination of @entity4 and @entity2 and adding of @entity3 is characterized by good endurance and high adherence to treatment.

title: [Changes of twenty-four-hour profile blood pressure anad its correction of XXXX with @entity1 on the background of combined antihypertensive therapy application].

answer: @entity0


abstract: ParB proteins bind centromere-like DNA sequences called parS sites and are involved in plasmid and chromosome segregation in bacteria. We previously showed that the opportunistic @entity0 pathogen @entity1 contains four parS sequences located close to the origin of replication which are bound by ParB. Using chromatin immunoprecipitation (ChIP), we found here that ParB spreads out from one of these parS sites, parS(-1.6  ), for more than 5  kb and occupies the nearby comCDE operon, which drives competence development. Competence allows @entity2 to take up DNA from its environment, thereby mediating horizontal gene transfer, and is also employed as a general stress response. Mutating parS(-1.6  ) or deleting parB resulted in transcriptional up-regulation of comCDE and ssbB (a gene belonging to the competence regulon), demonstrating that ParB acts as a repressor of competence. However, genome-wide transcription analysis showed that ParB is not a global transcriptional regulator. Different factors, such as the composition of the growth medium and antibiotic-induced stress, can trigger the sensitive switch driving competence. This work shows that the ParB-parS chromosome segregation machinery also influences this developmental process. IMPORTANCE: @entity1 (pneumococcus) is an important @entity0 pathogen responsible for more than a million deaths each year. Like all other organisms, @entity2 must be able to segregate its chromosomes properly. Not only is understanding the molecular mechanisms underlying chromosome segregation in @entity2 therefore of fundamental importance, but also, this knowledge might offer new leads for ways to target this pathogen. Here, we identified a link between the pneumococcal chromosome segregation system and the competence-developmental system. Competence allows @entity2 to take up and integrate exogenous DNA in its chromosome. This process plays a crucial role in successful adaptation to-and escape from-host defenses, antibiotic treatments, and vaccination strategies. We show that the chromosome segregation protein ParB acts as a repressor of competence. To the best of our knowledge, this is the first example of a ParB protein controlling bacterial competence.

title: The ParB-parS Chromosome Segregation System Modulates Competence Development in XXXX .

answer: @entity1


abstract: A @entity0 , now 28 years old, was diagnosed 6 years ago as chronic @entity5 by renal biopsy. From August 15, 1975 she complained of @entity2 , @entity8 and weight (about 7 kg within 2 weeks). Severe @entity1 (200/130 mmHg), @entity11 (123 mEq/liter), @entity3 , elevated plasma @entity6 activity (PRA), advanced @entity10 , and eye ground changes of KW-II were found. Dialysis treatment was started on September 2, 1975. From November 1975 massive amounts of @entity9 (5,000 mEq or more monthly) and water (26 liters or more monthly) were removed by the dialysis. These intensive dialyses resulted in an elevated PRA with recurrence of severe @entity1 . At the end of March 1976 she became almost blind with @entity7 of KW-IV. Potent @entity4 drugs including beta-blockers were administered, but no improvements were obtained. On March 31, 1976 nephrectomy was performed to save her life. Marked hyalinization of glomeruli and heavy thickening of intima in interlobular arteries were found in the removed kidneys. @entity12 was not recognized either macroscopically or histologically. In this @entity0 , the amount of @entity9 removed by the dialysis was dependent on her diastolic blood pressure and @entity9 concentration of the dialysis. It may be concluded that too enthusiastic dialysis may develop @entity1 due to excessive @entity6 release.

title: Development of XXXX in @entity0 with uremia under hemodialysis: a case report and discussions on its etiology.

answer: @entity1


abstract: A @entity0 , now 28 years old, was diagnosed 6 years ago as chronic @entity5 by renal biopsy. From August 15, 1975 she complained of @entity2 , @entity8 and weight (about 7 kg within 2 weeks). Severe @entity1 (200/130 mmHg), @entity11 (123 mEq/liter), @entity3 , elevated plasma @entity6 activity (PRA), advanced @entity10 , and eye ground changes of KW-II were found. Dialysis treatment was started on September 2, 1975. From November 1975 massive amounts of @entity9 (5,000 mEq or more monthly) and water (26 liters or more monthly) were removed by the dialysis. These intensive dialyses resulted in an elevated PRA with recurrence of severe @entity1 . At the end of March 1976 she became almost blind with @entity7 of KW-IV. Potent @entity4 drugs including beta-blockers were administered, but no improvements were obtained. On March 31, 1976 nephrectomy was performed to save her life. Marked hyalinization of glomeruli and heavy thickening of intima in interlobular arteries were found in the removed kidneys. @entity12 was not recognized either macroscopically or histologically. In this @entity0 , the amount of @entity9 removed by the dialysis was dependent on her diastolic blood pressure and @entity9 concentration of the dialysis. It may be concluded that too enthusiastic dialysis may develop @entity1 due to excessive @entity6 release.

title: Development of @entity1 in XXXX with uremia under hemodialysis: a case report and discussions on its etiology.

answer: @entity0


abstract: UNASSIGNED: Histoplasmosis is a progressive disease caused by dimorphic intracellular fungi and can prove fatal. Usually, it is present in immunocompromised individuals and immunocompetent individuals in the endemic zones. We report an unusual presentation of progressive disseminated @entity6 . The @entity0 in the present case report was immunocompetent @entity0 and had @entity2 , @entity1 , gradual weight loss, @entity7 and @entity3 . @entity6 ( @entity6 ) was diagnosed on microscopic examination and fungal culture of bone marrow, blood, skin biopsy and lymph node aspirate. The @entity0 died on seventh day of @entity5 . In the absence of predisposing factors and classical clinical presentation of @entity4 , lung, adrenal and oropharyngeal lesions, the disease posed a diagnostic challenge. Progressive disseminated @entity6 in @entity0 can be fatal despite timely diagnosis and therapy. In India, disseminated @entity6 is seen in immunocompetent hosts. All the pediatrics immunocompetent cases from India are also reviewed.

title: An Unusual Presentation of Disseminated Histoplasmosis: Case Report and Review of Pediatric Immunocompetent XXXX from India.

answer: @entity0


abstract: BACKGROUND: Cardiometabolic risk factors and related @entity3 represent major threats to healthy aging. OBJECTIVE: We aimed to estimate distribution, pharmacological treatment, and control of main cardiometabolic risk factors among older @entity0 . METHODS: This population-based study included 3363 @entity0 (age>= 60 years, 64.9% @entity0 ) in the Swedish National study on Aging and Care in Kungsholmen, in central Stockholm, Sweden (2001-2004). Data on demographics, cardiometabolic risk factors ( @entity4 , @entity2 , @entity1 , and high cholesterol), and medication use were collected through face-to-face interviews, clinical examinations, laboratory tests, and the inpatient register. Cardiometabolic risk factors were defined following the most commonly used criteria. Prevalence was standardized using local census data. RESULTS: The age- and sex-standardized prevalence of @entity1 , @entity2 , high cholesterol, and @entity4 was 9.5%, 12.8%, 49.7%, and 74.9%, respectively. The prevalence of @entity4 and @entity1 increased with age, whereas the prevalence of @entity2 and high cholesterol decreased with age. Forty-nine percent of older adults had two or more cardiometabolic risk factors; 9.8% had three or more. Overall, 55.5% of @entity0 with @entity4 , 50.3% with @entity1 , and 25.0% with high cholesterol received pharmacological treatment. Of those treated pharmacologically, 49.4%, 38.1%, and 85.5% reached therapeutic goals for @entity4 (blood pressure<150/90 mmHg), @entity1 (glycated haemoglobin<7%), and high cholesterol (total cholesterol<6.22 mmol/l), respectively. CONCLUSIONS: @entity4 , high cholesterol, and clustering of cardiometabolic risk factors were common among older @entity0 in Stockholm, but pharmacological treatment and control of these major factors can be improved. Appropriate management of cardiometabolic profiles among older @entity0 may help improve @entity3 and achieve healthy aging.

title: Prevalence, Pharmacological Treatment, and Control of Cardiometabolic Risk Factors among Older XXXX in Central Stockholm: A Population-Based Study.

answer: @entity0


abstract: One case of a very rare @entity7 of ovarium origin was observed and establishment of its cell lines from the fluid obtained by paracentitis was accomplished. This report is on the determination of the @entity0 and the biological characteristics of its cultured cells. ( @entity0 ) (1) This @entity0 was diagnosed as a malignant of the right ovary, using bimanual examination, selective angiography of the uterine artery, ultrasonic tomography, and abdominal ascitic cell examination. (2) The morphological type of @entity0 was based findings of @entity5 eosin. @entity4 , Mallory and @entity6 hematoxylin stainings. The @entity0 was diagnosed as an @entity2 and probably myogenic. However, a clear cross strain could not be demonstrated. (Cell biological characteristics) (1) Morphological characteristics of cultured cells: a) Phase-contrast microscopy and Papanicolaou staining revealed round or short and spindle shaped cells, with markedly enlarged nucleoli. These proliferated without exhibiting any tendency of contact inhibition. Also frequently recognized were giant cells, multinuclear cells, an some bizarre such as a starfish-shaped cell. b) Electron microscopy revealed that bundles of fibrils regarded as myofibrils existed in the cytoplasma, with dense patches within them, but a cross strain could not be demonstrated. (2) Morphological characteristics of the @entity0 cells grown in a nude @entity1 : a) The @entity0 cells demonstrated similarities to the original tissues by of H.E., @entity4 , and Mallary stainings. b) A number of fibrils recognized by the electron microscopic observation were 100 A in width and were arranged in a concentric circles. In addition to the light microscopic findings, the above findings indicated that this cell line originated from @entity3 . (3) Biological characteristics of the cultured cells: a) The number of chromosomes varied widely and spread aneuploidically, the highest chromosome number was 76. b) Doubling time, Saturation density, and plating efficiency was 31.2 hr, 1.2 x 10(5)/cm2 and 43.9% respectively. c) These cells had a high sensitivity for trypsin and started morphological change rapidly.

title: [Human XXXX and its cell culture (author's transl)].

answer: @entity2


abstract: BACKGROUND: The rich neovascularization of @entity1 ( @entity2 ) has a tendency for @entity7 with subsequent @entity4 . Nephrectomy or nephron-sparing surgery has rarely been used as a primary treatment in urgent situations. PURPOSE: To evaluate the safety and long-term outcomes for @entity0 treated by urgent transcatheter @entity8 (TAE) for spontaneous @entity1 with severe @entity4 . MATERIAL AND METHODS: A retrospective evaluation was performed of 25 renal @entity2 cases with spontaneous @entity4 confirmed by imaging. @entity9 ( @entity6 ) particles and coils of multiple sizes were used to embolize the spontaneous @entity1 . RESULTS: The technical success rate of TAE was 96% (24/25). One week post-TAE, 1 @entity0 with recurrent @entity4 underwent emergency nephrectomy. @entity3 affected 16 @entity0 with @entity5 ; 15 @entity0 resolved using conservative measures and one @entity0 received nephrectomy post TAE 1 week later. All @entity0 were followed up for 24-72 months (median, 50.2 months). Surgical treatment was avoided for 92% (23/25) of @entity0 , and the re-embolization rate was 0% at 2 years post TAE. In the 23 @entity0 without surgical treatment, the mean maximum diameter of renal @entity2 was reduced from 12.4        5.5   cm to 6.3        2.5   cm and no @entity4 occurred during follow-up. CONCLUSION: Urgent TAE is a technically feasible and minimally invasive procedure for controlling severe @entity4 and preservation of renal function following spontaneous @entity1 .

title: Urgent transcatheter @entity8 for the treatment of XXXX with spontaneous @entity4 .

answer: @entity1


abstract: BACKGROUND: The rich neovascularization of @entity1 ( @entity2 ) has a tendency for @entity7 with subsequent @entity4 . Nephrectomy or nephron-sparing surgery has rarely been used as a primary treatment in urgent situations. PURPOSE: To evaluate the safety and long-term outcomes for @entity0 treated by urgent transcatheter @entity8 (TAE) for spontaneous @entity1 with severe @entity4 . MATERIAL AND METHODS: A retrospective evaluation was performed of 25 renal @entity2 cases with spontaneous @entity4 confirmed by imaging. @entity9 ( @entity6 ) particles and coils of multiple sizes were used to embolize the spontaneous @entity1 . RESULTS: The technical success rate of TAE was 96% (24/25). One week post-TAE, 1 @entity0 with recurrent @entity4 underwent emergency nephrectomy. @entity3 affected 16 @entity0 with @entity5 ; 15 @entity0 resolved using conservative measures and one @entity0 received nephrectomy post TAE 1 week later. All @entity0 were followed up for 24-72 months (median, 50.2 months). Surgical treatment was avoided for 92% (23/25) of @entity0 , and the re-embolization rate was 0% at 2 years post TAE. In the 23 @entity0 without surgical treatment, the mean maximum diameter of renal @entity2 was reduced from 12.4        5.5   cm to 6.3        2.5   cm and no @entity4 occurred during follow-up. CONCLUSION: Urgent TAE is a technically feasible and minimally invasive procedure for controlling severe @entity4 and preservation of renal function following spontaneous @entity1 .

title: Urgent transcatheter XXXX for the treatment of @entity1 with spontaneous @entity4 .

answer: @entity8


abstract: BACKGROUND: The rich neovascularization of @entity1 ( @entity2 ) has a tendency for @entity7 with subsequent @entity4 . Nephrectomy or nephron-sparing surgery has rarely been used as a primary treatment in urgent situations. PURPOSE: To evaluate the safety and long-term outcomes for @entity0 treated by urgent transcatheter @entity8 (TAE) for spontaneous @entity1 with severe @entity4 . MATERIAL AND METHODS: A retrospective evaluation was performed of 25 renal @entity2 cases with spontaneous @entity4 confirmed by imaging. @entity9 ( @entity6 ) particles and coils of multiple sizes were used to embolize the spontaneous @entity1 . RESULTS: The technical success rate of TAE was 96% (24/25). One week post-TAE, 1 @entity0 with recurrent @entity4 underwent emergency nephrectomy. @entity3 affected 16 @entity0 with @entity5 ; 15 @entity0 resolved using conservative measures and one @entity0 received nephrectomy post TAE 1 week later. All @entity0 were followed up for 24-72 months (median, 50.2 months). Surgical treatment was avoided for 92% (23/25) of @entity0 , and the re-embolization rate was 0% at 2 years post TAE. In the 23 @entity0 without surgical treatment, the mean maximum diameter of renal @entity2 was reduced from 12.4        5.5   cm to 6.3        2.5   cm and no @entity4 occurred during follow-up. CONCLUSION: Urgent TAE is a technically feasible and minimally invasive procedure for controlling severe @entity4 and preservation of renal function following spontaneous @entity1 .

title: Urgent transcatheter @entity8 for the treatment of @entity1 with spontaneous XXXX .

answer: @entity4


abstract: PURPOSE: To evaluate the risk factors, recurrence rates, retreatments, and long-term @entity0 outcomes following proton beam therapy for @entity1 . DESIGN: Retrospective interventional case series. METHODS: All @entity0 treated with primary proton beam therapy for @entity1 at the oncology service at Charit  -Berlin and Helmholtz-Zentrum-Berlin between May 1998 and December 2008 were reviewed for local recurrence. Of 982 @entity0 , 982 eyes matched the inclusion criteria. The data were obtained from electronic health records, operative reports, discharge letters, and radiation planning. Comparisons of fundus photographs and ultrasound measurements were performed to assess the growth pattern of the tumor and to determine the success of retreatment, in the case that a globe-retaining therapy was undertaken. RESULTS: Of 982 @entity0 , 35 @entity0 (3.6%) developed local recurrence. The median follow-up was 60.7 months (6.0-170.4 months). Local control rate was 96.4% and the overall eye retention rate was 95.0% in this cohort. Local recurrence was correlated with a higher risk for metastasis and reduced survival. Largest tumor diameter was identified as the sole statistically significant risk factor for local recurrence (P = .00001). All globe-retaining retreatment approaches for local recurrence, including proton beam therapy, brachytherapy, and transpupillary thermotherapy used for recurrences at the tumor margins, showed good local tumor control and similar metastasis-free survivals. CONCLUSIONS: This study showed that each globe-retaining retreatment approach can result in satisfying local tumor control. In case of early detection of local recurrence, preservation of the globe can be warranted. Therefore, regularly performed follow-ups should be ensured.

title: Local Recurrence After Primary Proton Beam Therapy in XXXX : Risk Factors, Retreatment Approaches, and Outcome.

answer: @entity1


abstract: BACKGROUND AND AIM OF THE STUDY: The study aim was to investigate the mid-term outcome of tricuspid annuloplasty (TAP) in the repair of functional @entity1 ( @entity1 ), using the three-dimensional (3D) @entity3 ring with 'aggressive' stitches. METHODS: Between May 2007 and December 2012, a total of 165 @entity0 (104 @entity0 , 61 @entity0 ; mean age 68.0    9.0 years) underwent TAP using the @entity3 ring. Horizontal mattress sutures were placed on the annulus beyond the anteroseptal commissure and away from the deemed atrioventricular node artery/vein, which could be detected in the triangle of Koch. Transthoracic echocardiography was performed preoperatively and postoperatively. The severity of @entity1 was graded from 0 to 4. The mean follow up was 30.3    20.4 months. RESULTS: Both, @entity1 grade and pulmonary artery systolic pressure (PASP) were significantly improved postoperatively. After a median of 24 months, the mean @entity1 grade and PASP remained satisfactory. The overall survival rates were 97.6% and 94.8% at one and four years, respectively. The rates of freedom from recurrent @entity1 (grade > 2) were 97.3% and 90.5% at one and four years, respectively. There were neither @entity2 requiring new pacemaker implantation, nor reoperations for recurrent @entity1 . Multivariate analysis showed that recurrent @entity1 during the follow up period was significantly related to severe preoperative @entity1 . CONCLUSION: The clinical and echocardiographic results of TAP with the @entity3 ring and 'aggressive' stitches were excellent, though further follow up is mandatory to confirm the safety and durability of this technique. Detection of the prominent vessel in the triangle of Koch can be helpful in avoiding @entity2 after TAP.

title: Early and mid-term outcomes of aggressive tricuspid annuloplasty with the XXXX ring.

answer: @entity3


abstract: PURPOSE: Anterior shoulder dislocation can be associated with many lesions such as @entity1 , @entity4 ( @entity4 ), @entity5 or greater tuberosity fractures. It has been documented that early management of the associated injury affords better recovery of shoulder function. The aim of this study was to highlight the incidence of associated injuries after @entity6 . METHODS: A total of 240 @entity0 with @entity6 were subjected to complete history taking, neurovascular assessment and pre-reduction plain X-ray. An X-ray was taken immediately after reduction. Ultrasonography (US) and magnetic resonance imaging (MRI) were done within one  week after reduction in all @entity0 . Nerve conduction studies were ordered for any @entity0 with suspected @entity2 . RESULTS: Associated lesions were reported in 144 (60  %) @entity0 . @entity4 was the most common injury (67 cases). It was isolated in 34 @entity0 (14.15  %), while it was combined with other lesions in 33 cases (13.75  %). @entity2 was encountered in 38 @entity0 , of them 8 (3.33  %) were isolated and 30 (12.5  %) were combined. Greater tuberosity @entity3 was found in 37 @entity0 , of them 15 (6.25  %) were combined with @entity2 , and in the other 22 @entity0 (9.17  %) the @entity3 was isolated. All cases with Hill-Sachs and @entity1 were combined lesions with no isolated cases. There was a significant relation between the incidence of associated injuries and age, mechanism of injury and the affected side. CONCLUSIONS: Lesions associated with @entity6 are more frequent than expected. Thorough clinical examination and detailed imaging including US and MRI are mandatory to avoid a missed diagnosis.

title: Prevalence of associated injuries after XXXX : a prospective study.

answer: @entity6


abstract: Oesophageal lesion is the commonest visceral manifestation of @entity5 ( @entity5 ) affecting the quality of life and fraught with serious complications. The aim of this study was to evaluate clinical, endoscopic andmorphological manifestations of oesophageal lesion in @entity5 and its relationships with other clinical symptoms and pharmacotherapy of the disease. MATERIALS AND METHODS: 479 @entity0 with @entity5 (93.7% @entity0 , 6.3% @entity0 , mean age 48.7 +/- 19.2 yr). All of them underwent EGDS in 2005-2010. 123 @entity0 were examined for the detection of @entity4 ( @entity4 ), total screening regardless of complaints was conducted in 2010. Control group included 1018 age and sex-matched @entity0 with @entity2 who underwent EGDS in 2008-2009. RESULTS: Oesophageal lesions occurred much more frequently in @entity5 than in @entity2 . Oesophageal symptoms were documented in 70.0 and 29.9% cases, @entity7 in 28.8 and 1.5%, @entity8 in 22.5 and 2.2% @entity6 in 0.8 and 0% (p < 0.001). @entity4 manifested as intestinal metaplasia (histological study of mucosal biopsy) was found in 30 @entity5 @entity0 (4.2%). Screening revealed @entity4 in 8.9% of the @entity0 . The development of @entity7 was unrelated to the age of the @entity0 , duration of the disease and its form (localized or diffusive), lung pathology or @entity9 . Cytotoxic medicines significantly increased the frequency of @entity7 , it tended to increase under effect of NSAID and low doses of @entity1 . Long-term intake of PPI did not reduce the risk of @entity3 and @entity4 . CONCLUSION: Half of the @entity0 with @entity5 have @entity3 . Over 20% of them suffer its complications ( @entity7 and @entity6 ) and 9% have @entity4 . All such @entity0 need endoscopic study ofoesophagus regardless of clinical symptoms.

title: [Clinical, endoscopic and morphological manifestations of oesophageal lesion in XXXX ].

answer: @entity5


abstract: PURPOSE: To develop a new @entity1 ( @entity1 ) scheme using a content-based image retrieval (CBIR) approach for classification between the malignant and benign @entity2 depicted on the digital mammograms and assess @entity1 performance and reproducibility. METHODS: An image dataset including 820 regions of interest (ROIs) was used. Among them, 431 ROIs depict malignant lesions and 389 depict benign lesions. After applying an image preprocessing process to define the lesion center, two image features were computed from each ROI. The first feature is an average pixel value of a mapped region generated using a watershed algorithm. The second feature is an average pixel value difference between a ROI's center region and the rest of the image. A two-step CBIR approach uses these two features sequentially to search for ten most similar reference ROIs for each queried ROI. A similarity based classification score was then computed to predict the likelihood of the queried ROI depicting a @entity0 . To assess the reproducibility of the @entity1 scheme, we selected another independent testing dataset of 100 ROIs. For each ROI in the testing dataset, we added four randomly queried lesion center pixels and examined the variation of the classification scores. RESULTS: The area under the ROC curve (AUC) = 0.962    0.006 was obtained when applying a leave-one-out validation method to 820 ROIs. Using the independent testing dataset, the initial AUC value was 0.832    0.040, and using the median classification score of each ROI with five queried seeds, AUC value increased to 0.878    0.035. CONCLUSIONS: The authors demonstrated that (1) a simple and efficient CBIR scheme using two lesion density distribution related features achieved high performance in classifying @entity2 without actual lesion segmentation and (2) similar to the conventional @entity1 schemes using global optimization approaches, improving reproducibility is also one of the challenges in developing @entity1 schemes using a CBIR based regional optimization approach.

title: Assessment of performance and reproducibility of applying a content-based image retrieval scheme for classification of XXXX .

answer: @entity2


abstract: PURPOSE: To develop an automatic markerless 4D-CBCT projection sorting technique by using a @entity0 respiratory motion model extracted from the planning 4D-CT images. METHODS: Each phase of onboard 4D-CBCT is considered as a deformation of one phase of the prior planning 4D-CT. The deformation field map (DFM) is represented as a linear combination of three major deformation patterns extracted from the planning 4D-CT using principle component analysis (PCA). The coefficients of the PCA deformation patterns are solved by matching the digitally reconstructed radiograph (DRR) of the deformed volume to the onboard projection acquired. The PCA coefficients are solved for each single projection, and are used for phase sorting. Projections at the peaks of the Z direction coefficient are sorted as phase 1 and other projections are assigned into 10 phase bins by dividing phases equally between peaks. The 4D digital extended-cardiac-torso (XCAT) phantom was used to evaluate the proposed technique. Three scenarios were simulated, with different @entity1 motion amplitude (3cm to 2cm), @entity1 spatial shift (8mm SI), and @entity1 body motion phase shift (2 phases) from prior to on-board images. Projections were simulated over 180 degree scan-angle for the 4D-XCAT. The percentage of accurately binned projections across entire dataset was calculated to represent the phase sorting accuracy. RESULTS: With a changed @entity1 motion amplitude from 3cm to 2cm, markerless phase sorting accuracy was 100%. With a @entity1 phase shift of 2 phases w.r.t. body motion, the phase sorting accuracy was 100%. With a @entity1 spatial shift of 8mm in SI direction, phase sorting accuracy was 86.1%. CONCLUSION: The XCAT phantom simulation results demonstrated that it is feasible to use prior knowledge and motion modeling technique to achieve markerless 4D-CBCT phase sorting. National Institutes of Health Grant No. R01-CA184173 Varian Medical System.

title: SU-E-J-26: A Novel Technique for Markerless Self-Sorted 4D-CBCT Using XXXX Motion Modeling: A Feasibility Study.

answer: @entity0


abstract: PURPOSE: 4DCT has been widely used to generate internal @entity2 volume (ITV) for a @entity1 for treatment planning. However, @entity1 may show different respiratory motion on the treatment day. The purpose of this study is to evaluate 4D KV conebeam computed tomography (CBCT) for monitoring @entity2 interfractional motion variation between simulation and each fraction of stereotactic body radiation therapy (SBRT) for @entity1 . METHODS: 4D KV CBCT was acquired with the Elekta XVI system. The accuracy of 4D KV CBCT for image-guided radiation therapy (IGRT) was tested with a dynamic thorax motion phantom (CIRS, Virginia) with a linear amplitude of 2 cm. In addition, an adult anthropomorphic phantom (Alderson, Rando) with optically stimulated luminescence (OSL) dosimeters embedded at the center and periphery of a slab of solid water was used to measure the dose of 4D KV CBCT and to compare it with the dose with 3D KV CBCT. The image registration was performed by aligning\ each phase images of 4D KV CBCT to the planning images and the final couch shifts were calculated as a mean of all these individual shifts along each direction.A workflow was established based on these quality assurance tests for @entity1 @entity0 . RESULTS: 4D KV CBCT does not increase imaging dose in comparison to 3D KV CBCT. Acquisition of 4D KV CBCT is 4 minutes as compared to 2 minutes for 3D KV CBCT. Most of @entity0 showed a small daily variation of @entity2 respiratory motion about 2 mm. However, some @entity0 may have more than 5 mm variations of @entity2 respiratory motion. CONCLUSION: The radiation dose does not increase with 4D KV CBCT. 4D KV CBCT is a useful tool for monitoring interfractional variations of @entity2 respiratory motion before SBRT of @entity1 @entity0 .

title: SU-E-J-31: Monitor Interfractional Variation of Tumor Respiratory Motion Using 4D KV Conebeam Computed Tomography for Stereotactic Body Radiation Therapy of XXXX .

answer: @entity1