abstract: CONTEXT: @entity0 with @entity2 ( @entity2 ) can be rehabilitated if an early diagnosis and intervention is done. A negative magnetic resonance imaging (MRI) study utilizing routine sequences makes it difficult for the clinician to convince the family toward a long-term rehabilitation schedule. Diffusion tensor imaging (DTI) can demonstrate deranged @entity1 in developmentally delayed @entity0 having normal routine MRI. AIM: To evaluate the role of DTI-derived metrics for assessment of deranged @entity1 in developmentally delayed @entity0 having normal routine MRI. STUDY SETTING AND DESIGN: Prospective case control observational study conducted over a cross-section of referrals at a university-based teaching institute over a period of 2 years. @entity0 AND METHODS: Fifty cases of @entity2 and 15 age-sex matched controls (age group of 2-12 years) were included from those presenting voluntarily to the pediatric out- @entity0 services. Routine MRI and DTI were performed in both the groups following a standard protocol. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were calculated in certain pre-defined regions. STATISTICAL ANALYSIS: Central tendency was measured for each of the metrics using mean. Inter- and intra-group comparisons were performed using t-test. RESULTS: Twenty-three regions of interest with 46 variables were included in the final analysis. Nineteen (82.60%) regions of interest showed at least one statistically significant variable, while 24 out of 46 (54.34%) variables showed statistical significance for future consideration. The important regions to be evaluated in a case of @entity2 are the corpus callosum, bilateral forceps minor and forceps major, bilateral parietal lobes, bilateral post-central gyrus, and bilateral posterior limb internal capsule (PLIC). The regions which did not show any significance are bilateral pars triangularis and right frontal lobe. Other regions remained indeterminate and need further evaluation. CONCLUSION: DTI demonstrates @entity1 in @entity0 with @entity2 , having a normal routine MRI.

title: Diagnostic value of diffusion tensor imaging derived metrics as biomarkers of cerebral changes in XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity9 is a group of treatable noninfective @entity2 with great clinical implications. They have a close resemblance to @entity10 . We report the presence of significant titers of antimeasles antibody in some of our @entity0 with @entity9 resulting in diagnostic and therapeutic problems. @entity0 AND METHODS: @entity0 seen by us in the last 4 years with high titers (1:625 dilution) cerebrospinal fiuid (CSF) antimeasles antibody positivity were reviewed retrospectively. The data collected were assessed using SPSS- Statistical Package for Social Sciences Version 15.0 (IBM corporation) software. The groups which showed elevated antimeasles antibody titers but did not have other parameters suggestive of subacute sclerosing @entity8 (Group 2) were segregated and compared with those who had the typical features (Group 1) using Fisher's Exact Test. RESULTS: There were 33 patients with antimeasles antibody in CSF. Group 1 had 27 and Group 2 had 6 @entity0 . Group 1 had lower age, @entity1 , slow @entity7 , less generalized @entity4 , and focal @entity4 . Group 2 @entity0 belonged to the higher age, had significant @entity5 (P = 0.02), @entity6 (P = 0.0001). Slow @entity7 was significant in the first group (P = 0.028), and weakness was significant in the second group (P = 0.028) and double @entity3 in the second group (P = 0.0001). Magnetic resonance imaging showed significant gray matter and cerebellar involvement in Group 2 P = 0.005 and P = 0.028, respectively. CONCLUSIONS: @entity0 who show significant titers of antimeasles antibodies in the CSF but belonging to older age group with @entity5 , generalized @entity4 , double @entity3 , focal @entity7 , and electroencephalographic and imaging noncorroborative need to be investigated for @entity9 in view of the great prognostic and therapeutic relevance.

title: Elevated antimeasles antibody titre: An association in XXXX .

answer: @entity9


abstract: BACKGROUND: This study aimed to assess the endoscopic burden of bariatric surgical procedures at our trust. This is an enhanced parallel study to "The Hidden Endoscopic burden of Roux-en-Y Gastric Bypass" published in Frontline Gastroenterology in 2013 incorporating the data for sleeve gastrectomy and comparison with @entity1 ( @entity1 ). METHODS: This is a retrospective study that included 211 @entity0 undergoing sleeve gastrectomy over a 34-month period. We utilized previously collected data for the @entity1 @entity0 cohort which included 553 @entity0 over a 29-month period. We searched our hospital endoscopic database for @entity0 who underwent post-operative endoscopy for indications related to their surgery. RESULTS: 16.6% of the sleeve gastrectomy @entity0 required post-operative endoscopy, of whom 11.4% underwent therapeutic procedures. This compares to 20.4% of the @entity1 cohort of whom 50.4% needed therapeutic procedures (P<0.001). 1.9% of sleeve gastrectomy @entity0 encountered a post-operative staple line leak and collectively required 29 endoscopic procedures. One @entity0 also developed stricturing (0.47%) requiring 18 pneumatic dilatations. 11.4% of the @entity1 cohort developed an anastomotic stricture requiring 57 balloon dilatation procedures. To date, these procedures have accumulated an equivalent cost of    159,898 in endoscopy tariffs, or    177 per @entity1 and    373 per sleeve gastrectomy performed. CONCLUSIONS: Bariatric surgery can have significant implications in terms of @entity0 morbidity and financial cost. Having a local bariatric surgery service increases the demand for endoscopic procedures in our hospital, both in investigating for and dealing with post-operative complications. Provision of extra resources and expertise needs to be taken into account.

title: The hidden endoscopic burden of sleeve gastrectomy and its comparison with XXXX .

answer: @entity1


abstract: UNASSIGNED: Dracocephalum kotschyi Boiss. (Labiatae) is a traditional medicine which is believed to have antispasmodic and analgesic activities. The antispasmodic action of D. kotschyi essential oil has been shown in a previous report. The objective of this research was to study antispasmodic activity of hydroalcoholic extract of D. kotschyi on ileum contractions. Hydroalcoholic extract was obtained from aerial part of D. kotschyi using percolation method. For antispasmodic studies, a portion of @entity0 ileum was suspended under 1g tension in Tyrode's solution at 37   C and gassed with @entity3 . Effect of the D. kotschyi extract was assessed on ileum contractions induced by @entity4 (80 mM), @entity1 ( @entity2 , 500 nM) and electrical field stimulation (EFS). The D. kotschyi extract concentration dependently inhibited the response to @entity4 (IC50 =36    5.1  g/ml), @entity2 (IC50 =101    9.5  g/ml), EFS-1 (IC50 =96    7.1  g/ml) and EFS-2 (IC50 =53    4.3  g/ml). From this experiment it was concluded that D. kotschyi extract possessed potent antispasmodic activity. Therefore, identification of the active component(s) is (are) recommended in order to find the best lead compound for drug development.

title: Antispasmodic effect of Dracocephalum kotschyi hydroalcoholic extract on XXXX ileum contraction.

answer: @entity0


abstract: BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is becoming the most performed bariatric procedure; however, data available on long-term follow-up are scanty. OBJECTIVES: The aim of the present study was to evaluate the 5-year efficacy of LSG on @entity3 , @entity4 ( @entity4 ) symptoms, and @entity1 -associated co-morbidities. SETTING: Tertiary-care referral hospital. METHODS: This study retrospectively analyzed 105 @entity1 @entity0 undergoing LSG from January 2006 to December 2009. The preoperative evaluation included demographic characteristics, evaluation of co-morbidities, a double-contrast barium swallow, and an @entity2 . The following data were collected at 1, 3, and 5 years after surgery: weight, improvement/remission of co-morbidities, complications, and revisional surgery. RESULTS: According to preoperative body mass index (BMI), @entity0 were divided into Group 1 (n = 61) with BMI <=50 kg/m(2) and Group 2 (n = 44) with BMI>50 kg/m(2). The follow-up rate was 94% after 5 years (n = 99). Delta BMI (BMI at follow-up-preoperative BMI) was significantly higher in Group 2 than in Group 1 at 1-3 years and 5 years (P<.001). Furthermore, at 5 years, Group 2 showed a significantly higher percentage total @entity3 (%TWL) (26.6%  18.3% versus 33.5%  12.9%, P = .006) than Group 1, whereas percentage excess @entity3 was similar (58.4%  21.8% versus 55.3%  19.5%, P = .5).Younger age at surgery and absence of postoperative @entity4 were associated with a better %TWL at 5 years (P<.001 and P = .03). CONCLUSION: LSG is an effective procedure at long-term, with good @entity3 outcomes and with a considerable improvement of @entity1 -associated co-morbidities. Younger age at surgery and absence of postoperative @entity4 were associated with a better %TWL at 5 years.

title: Five-year results of laparoscopic sleeve gastrectomy: effects on XXXX and co-morbidities.

answer: @entity4


abstract: OBJECTIVE: Since 2000, we have given B-cell depletion therapy (BCDT) with rituximab to 76 @entity0 with active @entity1 refractory to standard immunosuppression. Twenty-four of these @entity0 have now received repeated cycles of BCDT. The aims of the study were to: (i) assess the efficacy and safety of repeated cycles of BCDT in treating refractory @entity1 ; and (ii) assess whether retreatment produced a more sustained clinical response. METHODS: BCDT was administered using CYC 750 mg, @entity2 125-250 mg and rituximab 1 g given intravenously on two occasions, 2 weeks apart. @entity0 were reviewed at 1-2 monthly intervals and disease activity assessed using the BILAG activity index and serological markers. Clinical response was categorized as complete or partial remission, or no response, based on the change in BILAG scores. RESULTS: Eighteen @entity0 had sufficient data for detailed analysis. All were female; mean age 29.9 years; mean duration of follow-up 58.7 months. Two @entity0 died during follow-up and there were two infusion reactions. Disease activity was significantly reduced after both cycles of BCDT at 6 months. More @entity0 achieved disease remission after the second cycle (82 vs 61% first cycle), which was maintained in 65% at 12 months (vs 39% first cycle). The time to disease flare was significantly longer after the second cycle (P < 0.001) and 33% of our @entity0 have still not flared to date following retreatment (mean follow-up 24.5 months). CONCLUSION: Repeated cycles of BCDT with rituximab are effective in treating refractory @entity1 and has a favourable safety profile. Retreatment may produce a more sustained clinical response.

title: The efficacy of repeated treatment with B-cell depletion therapy in XXXX : an evaluation.

answer: @entity1


abstract: BACKGROUND: Although several risk factors for prolonged length of stay (LOS) and increased hospital cost have been identified, the association between LOS, hospital cost, and neutrophil-to-lymphocyte ratio (NLR) has not yet been investigated. We aimed to investigate the influence of NLR on LOS and hospital cost in @entity0 with acute @entity3 . METHODS: @entity0 with acute @entity3 diagnosed within 24 hours of symptom onset were included. Univariate analysis and stepwise multiple regression analysis were used to identify independent predictors of LOS and hospital cost. RESULTS: A total of 346 @entity0 were included in the final analysis. The median LOS was 11 days (range 8-13 days). The median acute hospital cost per @entity0 was 19,030.6   RMB (U.S.   3065.8) (range 14,450.8   RMB-25,218.2   RMB). Neutrophil count to lymphocyte count (NLR) (P   <   .001), @entity1 (P   =   .034), @entity2 subtype (P   =   .005), and @entity2 severity (P   <   .001) were significantly associated with prolonged LOS in the univariate analysis. NLR (P   <   .001), smoking (P   =   .04), @entity2 subtype (P   <   .001), @entity2 severity (P   <   .001), and LOS (P   <   .001) were significantly associated with increased hospital cost in the univariate analysis. Multivariate regression analysis showed that NLR was an independent predictor of both LOS and acute hospital cost. In addition, high NLR was significantly correlated with poor outcome at discharge, prolonged LOS, and increased hospital cost. CONCLUSIONS: NLR is significantly associated with LOS and acute hospital cost in @entity0 presenting with acute @entity3 . It is a simple, inexpensive, and readily available biomarker and may serve as a clinically practical indicator for assessing the economic burden of @entity2 .

title: Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in @entity0 with Acute XXXX .

answer: @entity3


abstract: BACKGROUND: Although several risk factors for prolonged length of stay (LOS) and increased hospital cost have been identified, the association between LOS, hospital cost, and neutrophil-to-lymphocyte ratio (NLR) has not yet been investigated. We aimed to investigate the influence of NLR on LOS and hospital cost in @entity0 with acute @entity3 . METHODS: @entity0 with acute @entity3 diagnosed within 24 hours of symptom onset were included. Univariate analysis and stepwise multiple regression analysis were used to identify independent predictors of LOS and hospital cost. RESULTS: A total of 346 @entity0 were included in the final analysis. The median LOS was 11 days (range 8-13 days). The median acute hospital cost per @entity0 was 19,030.6   RMB (U.S.   3065.8) (range 14,450.8   RMB-25,218.2   RMB). Neutrophil count to lymphocyte count (NLR) (P   <   .001), @entity1 (P   =   .034), @entity2 subtype (P   =   .005), and @entity2 severity (P   <   .001) were significantly associated with prolonged LOS in the univariate analysis. NLR (P   <   .001), smoking (P   =   .04), @entity2 subtype (P   <   .001), @entity2 severity (P   <   .001), and LOS (P   <   .001) were significantly associated with increased hospital cost in the univariate analysis. Multivariate regression analysis showed that NLR was an independent predictor of both LOS and acute hospital cost. In addition, high NLR was significantly correlated with poor outcome at discharge, prolonged LOS, and increased hospital cost. CONCLUSIONS: NLR is significantly associated with LOS and acute hospital cost in @entity0 presenting with acute @entity3 . It is a simple, inexpensive, and readily available biomarker and may serve as a clinically practical indicator for assessing the economic burden of @entity2 .

title: Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in XXXX with Acute @entity3 .

answer: @entity0


abstract: OBJECTIVE: To analyze the clinical and pathological characteristics of @entity1 ( @entity1 ) cases and to discuss the diagnosis, treatment, and prognosis of @entity1 . MATERIALS AND METHODS: The clinical and pathological data of eight @entity0 with @entity1 at Istanbul Medical Faculty Hospital from 1988 to 2010 were analyzed retrospectively. RESULTS: The mean age of the @entity0 was 31 years. The antecedent pregnancy was full-term delivery in most of the @entity0 (6/8, 75%). The mean interval from last pregnancy to diagnosis of @entity1 was 35 months (range, six to 192). Serum human chorionic gonadotropin (hCG) levels at the time of diagnosis ranged from 0.1 to 2280 mIU/ml (mean, 614). All @entity0 had Stage 1 disease and ultimately underwent hysterectomy. None of the @entity0 received adjuvant chemotherapy. One @entity0 died of an unknown reason, one month after the surgery. The rest of the @entity0 were alive and without evidence of disease after an average of 3.5 years (range, one to 11) of follow-up. CONCLUSION: Hysterectomy alone can provide long-term survival in early-stage disease.

title: XXXX : report of a tertiary center experience.

answer: @entity1


abstract: Knowledge on parasites of the genus Besnoitia, especially Besnoitia caprae, is sparse. Besnoitia caprae, an obligate intracellular protozoan parasite belonging to the phylum Apicomplexa, is the causative agent of @entity9 @entity8 . This experiment was conducted to determine the infectivity of the bradyzoites and the resultant histopathological lesions after inoculation of B. caprae bradyzoites in the embryonated egg. Eight groups, each having six embryonated eggs, were assigned in this experiment. Seven groups were inoculated with different doses of B. caprae bradyzoite inoculums (1x10(3), 1x10(4), 1x10(5), 1x10(6), 5x10(6), 1x10(7) and 2x10(7)) via the @entity7 route. The 8th group was considered as control. The embryos inoculated with higher doses showed mortality between 14 and 21 days of incubation (5-12 days post-infection). Those embryos that received lower doses were hatched on day 21 of incubation; however, they presented loss of feathers and @entity5 and showed @entity3 in the skin of the feet regions. Histopathological sections of the skin revealed the presence of @entity4 , @entity3 and @entity0 responses. Some of the @entity6 were euthanized after 50 days postinfection (DPI) and histopathological examination of their tissues revealed @entity4 and @entity1 with the presence of mononuclear cells infiltration in the liver and heart with @entity2 . It seems that the embryonated eggs could be a useful model to study the parasite's biology.

title: Experimental infection of embryonated eggs of XXXX with Besnoitia caprae.

answer: @entity6


abstract: BACKGROUND: Hemostatic procedures by means of electrical coagulation or application of topical agents are widely used to avoid @entity3 during microsurgical reconstruction of peripheral nerves. It is speculated, however, that extensive hemostasis could provoke @entity1 . OBJECTIVE: To examine the effects of 2 intraoperative hemostatic procedures on peripheral nerve regeneration. METHODS: In 36 adult @entity2 divided into 3 groups, the median nerve was transected and repaired by end-to-end neurorrhaphy. During surgery, bleeding was treated in groups 2 and 3 by application of either the topical hemostatic agent Floseal or routine @entity4 . The degree of nerve regeneration was assessed in terms of motor function recovery using weekly grasping test evaluation for 3 months, muscle mass recovery of flexor digitorum sublimis, and stereological assessment of myelinated axon regeneration. RESULTS: Neither of the 2 applied hemostatic methods induced any negative effects on nerve regeneration as defined by grip strength, muscle mass recovery, and morphology of myelinated nerve fibers. In contrast, Floseal-treated animals showed a faster progression of motor function recovery, and animals subjected to @entity4 revealed a higher muscle mass recovery compared with the control group. CONCLUSION: Controlled application of @entity4 or Floseal does not exert a negative effect on the nerve regeneration outcome in @entity2 . We propose that these methods can be applied safely to @entity0 .

title: Application of two different hemostatic procedures during microsurgical median nerve reconstruction in the XXXX does not hinder axonal regeneration.

answer: @entity2


abstract: BACKGROUND: Antiviral drugs are critical adjuncts to @entity4 vaccination. This study determined the in vitro susceptibilities of @entity4 A and B viruses isolated in the 2010-2011 season in Russia to the @entity6 inhibitor @entity5 and the hemagglutinin fusion inhibitor @entity8 and clinical efficacy of this antiviral drugs in this season. METHODS: The antiviral potency of these drugs against A(H1N1)pdm09 virus in @entity1 was assessed. Importantly, the clinical effectiveness of @entity5 and @entity8 was evaluated in a retrospective study conducted in 26 regions of Russia. RESULTS: All tested viruses (n=36) were susceptible to @entity5 and @entity8 in vitro. @entity5 (10mg/kg/day) and @entity8 (60mg/kg/day) significantly increased the survival of @entity1 challenged with A/California/04/2009 (H1N1)pdm09 virus (p<0.05). @entity3 was laboratory-confirmed in 442 @entity0 among 1462 @entity0 hospitalized with @entity7 . The treatment of @entity3 @entity0 within 48h of symptom onset with @entity5 and @entity8 was associated with a significant decrease in the duration of illness (2-3 days) and symptoms (p<0.001). @entity2 was observed in none of the @entity0 treated with @entity5 and in 0.3% of the @entity0 treated with @entity8 , compared to 23.7% of @entity0 who did not receive antiviral therapy (p<0.001). CONCLUSIONS: This study provided experimental and clinical evidence of the efficacy of @entity5 and @entity8 against @entity4 viruses, representatives of which have continued to circulate in post-pandemic seasons.

title: Virus susceptibility and clinical effectiveness of anti- XXXX drugs during the 2010-2011 @entity4 season in Russia.

answer: @entity4


abstract: BACKGROUND: Antiviral drugs are critical adjuncts to @entity4 vaccination. This study determined the in vitro susceptibilities of @entity4 A and B viruses isolated in the 2010-2011 season in Russia to the @entity6 inhibitor @entity5 and the hemagglutinin fusion inhibitor @entity8 and clinical efficacy of this antiviral drugs in this season. METHODS: The antiviral potency of these drugs against A(H1N1)pdm09 virus in @entity1 was assessed. Importantly, the clinical effectiveness of @entity5 and @entity8 was evaluated in a retrospective study conducted in 26 regions of Russia. RESULTS: All tested viruses (n=36) were susceptible to @entity5 and @entity8 in vitro. @entity5 (10mg/kg/day) and @entity8 (60mg/kg/day) significantly increased the survival of @entity1 challenged with A/California/04/2009 (H1N1)pdm09 virus (p<0.05). @entity3 was laboratory-confirmed in 442 @entity0 among 1462 @entity0 hospitalized with @entity7 . The treatment of @entity3 @entity0 within 48h of symptom onset with @entity5 and @entity8 was associated with a significant decrease in the duration of illness (2-3 days) and symptoms (p<0.001). @entity2 was observed in none of the @entity0 treated with @entity5 and in 0.3% of the @entity0 treated with @entity8 , compared to 23.7% of @entity0 who did not receive antiviral therapy (p<0.001). CONCLUSIONS: This study provided experimental and clinical evidence of the efficacy of @entity5 and @entity8 against @entity4 viruses, representatives of which have continued to circulate in post-pandemic seasons.

title: Virus susceptibility and clinical effectiveness of anti- @entity4 drugs during the 2010-2011 XXXX season in Russia.

answer: @entity4


abstract: BACKGROUND: @entity7 is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and @entity7 control has increasingly shifted from the state to the individual livestock owner. To assess the sustainability of these localised control efforts, this study investigates biological and management risk factors associated with trypanosome infections detected by polymerase chain reaction (PCR), in a range of domestic livestock at the local scale in Busia, Kenya. Busia District also remains endemic for @entity0 @entity1 with sporadic cases of @entity1 reported. RESULTS: In total, trypanosome infections were detected in 11.9% (329) out of the 2773 livestock sampled in Busia District. Multivariable logistic regression revealed that host species and @entity3 age affected overall trypanosome @entity2 , with significantly increased odds of @entity2 for @entity3 older than 18 months, and significantly lower odds of @entity2 in @entity5 and small ruminants. Different grazing and watering management practices did not affect the odds of trypanosome @entity2 , adjusted by host species. Neither @entity4 nor condition score significantly affected the odds of trypanosome @entity2 in @entity3 . @entity0 infective @entity6 rhodesiense were detected in 21.5% of animals infected with @entity6 s.l. (29/135) amounting to 1% (29/2773) of all sampled livestock, with significantly higher odds of @entity6 rhodesiense infections in @entity6 s.l. infected @entity5 (OR= 4.3, 95%CI 1.5-12.0) than in @entity6 s.l. infected @entity3 or small ruminants. CONCLUSIONS: Although @entity3 are the dominant reservoir of trypanosome @entity2 it is unlikely that targeted treatment of only visibly diseased @entity3 will achieve sustainable interruption of transmission for either animal infective or zoonotic @entity0 infective @entity7 , since most infections were detected in @entity3 that did not exhibit classical clinical signs of @entity7 . @entity5 were also found to be reservoirs of @entity2 for T. b. rhodesiense and present a risk to local communities.

title: Factors associated with acquisition of @entity0 XXXX in domestic livestock in Western Kenya.

answer: @entity2


abstract: BACKGROUND: @entity7 is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and @entity7 control has increasingly shifted from the state to the individual livestock owner. To assess the sustainability of these localised control efforts, this study investigates biological and management risk factors associated with trypanosome infections detected by polymerase chain reaction (PCR), in a range of domestic livestock at the local scale in Busia, Kenya. Busia District also remains endemic for @entity0 @entity1 with sporadic cases of @entity1 reported. RESULTS: In total, trypanosome infections were detected in 11.9% (329) out of the 2773 livestock sampled in Busia District. Multivariable logistic regression revealed that host species and @entity3 age affected overall trypanosome @entity2 , with significantly increased odds of @entity2 for @entity3 older than 18 months, and significantly lower odds of @entity2 in @entity5 and small ruminants. Different grazing and watering management practices did not affect the odds of trypanosome @entity2 , adjusted by host species. Neither @entity4 nor condition score significantly affected the odds of trypanosome @entity2 in @entity3 . @entity0 infective @entity6 rhodesiense were detected in 21.5% of animals infected with @entity6 s.l. (29/135) amounting to 1% (29/2773) of all sampled livestock, with significantly higher odds of @entity6 rhodesiense infections in @entity6 s.l. infected @entity5 (OR= 4.3, 95%CI 1.5-12.0) than in @entity6 s.l. infected @entity3 or small ruminants. CONCLUSIONS: Although @entity3 are the dominant reservoir of trypanosome @entity2 it is unlikely that targeted treatment of only visibly diseased @entity3 will achieve sustainable interruption of transmission for either animal infective or zoonotic @entity0 infective @entity7 , since most infections were detected in @entity3 that did not exhibit classical clinical signs of @entity7 . @entity5 were also found to be reservoirs of @entity2 for T. b. rhodesiense and present a risk to local communities.

title: Factors associated with acquisition of XXXX @entity2 in domestic livestock in Western Kenya.

answer: @entity0


abstract: A 72-year-old @entity0 with a known left @entity6 , left-sided @entity3 , and a recently diagnosed right infratemporal fossa (ITF) @entity5 , presented with @entity4 in his right ear. Imaging revealed right-sided skull base extension and a large @entity1 component. The @entity0 underwent a frontotemporal crainiotomy with concomitant ITF approach. Complete @entity1 resection was possible, though invasion of the otic capsule was present. Immediately postresection, a cochlear implant (CI) was performed via a transmastoid approach. Full electrode insertion was achieved and confirmed by visualization through the dehiscent middle fossa floor. @entity2 was then performed with a free fat graft. Postoperative imaging confirmed complete @entity1 resection (Simpson grade I) and adequate CI placement. Follow-up magnetic resonance imaging was performed at 6 and 12 months, and no @entity1 recurrence was seen. Prior to CI activation, the @entity0 was completely deaf bilaterally. At 18-month follow-up, however, excellent hearing was achieved with the right CI (16 of 22 electrodes active), and the @entity0 is now conversational with no obvious deficit. His cognitive function is excellent, corresponding to preoperative status, and he is independent in his activities of daily living. Following adjuvant radiation, our @entity0 remains disease free at 18 months.

title: Concurrent Cochlear Implantation with Resection of Skull Base @entity5 following Sudden XXXX in an Only Hearing Ear.

answer: @entity3


abstract: A 72-year-old @entity0 with a known left @entity6 , left-sided @entity3 , and a recently diagnosed right infratemporal fossa (ITF) @entity5 , presented with @entity4 in his right ear. Imaging revealed right-sided skull base extension and a large @entity1 component. The @entity0 underwent a frontotemporal crainiotomy with concomitant ITF approach. Complete @entity1 resection was possible, though invasion of the otic capsule was present. Immediately postresection, a cochlear implant (CI) was performed via a transmastoid approach. Full electrode insertion was achieved and confirmed by visualization through the dehiscent middle fossa floor. @entity2 was then performed with a free fat graft. Postoperative imaging confirmed complete @entity1 resection (Simpson grade I) and adequate CI placement. Follow-up magnetic resonance imaging was performed at 6 and 12 months, and no @entity1 recurrence was seen. Prior to CI activation, the @entity0 was completely deaf bilaterally. At 18-month follow-up, however, excellent hearing was achieved with the right CI (16 of 22 electrodes active), and the @entity0 is now conversational with no obvious deficit. His cognitive function is excellent, corresponding to preoperative status, and he is independent in his activities of daily living. Following adjuvant radiation, our @entity0 remains disease free at 18 months.

title: Concurrent Cochlear Implantation with Resection of Skull Base XXXX following Sudden @entity3 in an Only Hearing Ear.

answer: @entity5


abstract: BACKGROUND: The objective of this study was to assess the outcome of open inferior capsular shift for multidirectional shoulder instability in @entity0 with generalized @entity3 or @entity2 . METHODS: Data were obtained for 18 open inferior capsular shift surgeries in 15 adolescent @entity0 with generalized @entity3 or @entity2 with a mean follow-up of 7.5 years. End points were subjective clinical outcome ( @entity1 , stability, satisfaction, return to sport), objective clinical outcome (recurrence, complications), and functional outcome scores (American Shoulder and Elbow Surgeons, 11-item version of the Disabilities of Arm, Shoulder and Hand). RESULTS: Thirteen @entity0 (87%) reported improved @entity1 and stability and were satisfied with the procedure. Nine @entity0 (64%) were able to return to sports. One @entity0 (7%) was dissatisfied with continuous @entity1 and recurrent instability and considered a surgical failure. Seven @entity0 (47%) reported no further episodes of instability. The mean American Shoulder and Elbow Surgeons score at a mean of 7.5 years of follow-up was 88        10 points, and the mean score for the 11-item version of the Disabilities of Arm, Shoulder and Hand was 14        14 points. DISCUSSION: The management of multidirectional shoulder instability in adolescent @entity0 with generalized @entity3 or @entity2 is challenging. Open inferior capsular shift results in improvement in subjective and objective shoulder function and stability in adolescent @entity0 with @entity3 or @entity2 who have failed nonoperative treatment. We found no effect of the recalled number of prior dislocations, laterality, and type of hyperlaxity on subjective and objective clinical outcomes. LEVEL OF EVIDENCE: Level IV; Case Series; Treatment Study.

title: Open inferior capsular shift for multidirectional shoulder instability in adolescents with generalized XXXX or @entity2 .

answer: @entity3


abstract: BACKGROUND: The objective of this study was to assess the outcome of open inferior capsular shift for multidirectional shoulder instability in @entity0 with generalized @entity3 or @entity2 . METHODS: Data were obtained for 18 open inferior capsular shift surgeries in 15 adolescent @entity0 with generalized @entity3 or @entity2 with a mean follow-up of 7.5 years. End points were subjective clinical outcome ( @entity1 , stability, satisfaction, return to sport), objective clinical outcome (recurrence, complications), and functional outcome scores (American Shoulder and Elbow Surgeons, 11-item version of the Disabilities of Arm, Shoulder and Hand). RESULTS: Thirteen @entity0 (87%) reported improved @entity1 and stability and were satisfied with the procedure. Nine @entity0 (64%) were able to return to sports. One @entity0 (7%) was dissatisfied with continuous @entity1 and recurrent instability and considered a surgical failure. Seven @entity0 (47%) reported no further episodes of instability. The mean American Shoulder and Elbow Surgeons score at a mean of 7.5 years of follow-up was 88        10 points, and the mean score for the 11-item version of the Disabilities of Arm, Shoulder and Hand was 14        14 points. DISCUSSION: The management of multidirectional shoulder instability in adolescent @entity0 with generalized @entity3 or @entity2 is challenging. Open inferior capsular shift results in improvement in subjective and objective shoulder function and stability in adolescent @entity0 with @entity3 or @entity2 who have failed nonoperative treatment. We found no effect of the recalled number of prior dislocations, laterality, and type of hyperlaxity on subjective and objective clinical outcomes. LEVEL OF EVIDENCE: Level IV; Case Series; Treatment Study.

title: Open inferior capsular shift for multidirectional shoulder instability in adolescents with generalized @entity3 or XXXX .

answer: @entity2


abstract: Stenting may provide a new, less invasive therapeutic option for @entity2 . However, a conventional porous stent may be insufficient in modifying the blood flow for clinical @entity3 . We designed an asymmetric stent consisting of a low porosity patch welded onto a porous stent for an @entity2 of a specific @entity0 geometry to block the strong inflow jet. To evaluate the effect of the patch on aneurysmal flow dynamics, we "virtually" implanted it into the @entity0 's @entity3 geometry and performed @entity4 ( @entity4 ) analysis. The patch was computationally deformed to fit into the vessel lumen segmented from the @entity0 CT reconstructions. After the flow calculations, a patch with the same design was fabricated using laser cutting techniques and welded onto a commercial porous stent, creating a @entity0 -specific asymmetric stent. This stent was implanted into a phantom, which was imaged with X-ray angiography. The hemodynamics of untreated and stented @entity3 were compared both computationally and experimentally. It was found from @entity4 of the @entity0 @entity3 that the asymmetric stent effectively blocked the strong inflow jet into the @entity3 and eliminated the flow impingement on the @entity3 wall at the dome. The impact zone with elevated wall shear stress was eliminated, the aneurysmal flow activity was substantially reduced, and the flow was considerably reduced. Experimental observations corresponded well qualitatively with the @entity4 results. The demonstrated asymmetric stent could lead to a new minimally invasive image guided intervention to reduce @entity3 growth and @entity1 .

title: Evaluation of an asymmetric stent patch design for a @entity0 specific @entity2 using Computational Fluid Dynamic ( XXXX ) calculations in the Computed Tomography (CT) derived lumen.

answer: @entity4


abstract: Stenting may provide a new, less invasive therapeutic option for @entity2 . However, a conventional porous stent may be insufficient in modifying the blood flow for clinical @entity3 . We designed an asymmetric stent consisting of a low porosity patch welded onto a porous stent for an @entity2 of a specific @entity0 geometry to block the strong inflow jet. To evaluate the effect of the patch on aneurysmal flow dynamics, we "virtually" implanted it into the @entity0 's @entity3 geometry and performed @entity4 ( @entity4 ) analysis. The patch was computationally deformed to fit into the vessel lumen segmented from the @entity0 CT reconstructions. After the flow calculations, a patch with the same design was fabricated using laser cutting techniques and welded onto a commercial porous stent, creating a @entity0 -specific asymmetric stent. This stent was implanted into a phantom, which was imaged with X-ray angiography. The hemodynamics of untreated and stented @entity3 were compared both computationally and experimentally. It was found from @entity4 of the @entity0 @entity3 that the asymmetric stent effectively blocked the strong inflow jet into the @entity3 and eliminated the flow impingement on the @entity3 wall at the dome. The impact zone with elevated wall shear stress was eliminated, the aneurysmal flow activity was substantially reduced, and the flow was considerably reduced. Experimental observations corresponded well qualitatively with the @entity4 results. The demonstrated asymmetric stent could lead to a new minimally invasive image guided intervention to reduce @entity3 growth and @entity1 .

title: Evaluation of an asymmetric stent patch design for a @entity0 specific XXXX using Computational Fluid Dynamic ( @entity4 ) calculations in the Computed Tomography (CT) derived lumen.

answer: @entity2


abstract: Stenting may provide a new, less invasive therapeutic option for @entity2 . However, a conventional porous stent may be insufficient in modifying the blood flow for clinical @entity3 . We designed an asymmetric stent consisting of a low porosity patch welded onto a porous stent for an @entity2 of a specific @entity0 geometry to block the strong inflow jet. To evaluate the effect of the patch on aneurysmal flow dynamics, we "virtually" implanted it into the @entity0 's @entity3 geometry and performed @entity4 ( @entity4 ) analysis. The patch was computationally deformed to fit into the vessel lumen segmented from the @entity0 CT reconstructions. After the flow calculations, a patch with the same design was fabricated using laser cutting techniques and welded onto a commercial porous stent, creating a @entity0 -specific asymmetric stent. This stent was implanted into a phantom, which was imaged with X-ray angiography. The hemodynamics of untreated and stented @entity3 were compared both computationally and experimentally. It was found from @entity4 of the @entity0 @entity3 that the asymmetric stent effectively blocked the strong inflow jet into the @entity3 and eliminated the flow impingement on the @entity3 wall at the dome. The impact zone with elevated wall shear stress was eliminated, the aneurysmal flow activity was substantially reduced, and the flow was considerably reduced. Experimental observations corresponded well qualitatively with the @entity4 results. The demonstrated asymmetric stent could lead to a new minimally invasive image guided intervention to reduce @entity3 growth and @entity1 .

title: Evaluation of an asymmetric stent patch design for a XXXX specific @entity2 using Computational Fluid Dynamic ( @entity4 ) calculations in the Computed Tomography (CT) derived lumen.

answer: @entity0


abstract: Invasion and @entity1 are the main cause of @entity3 in @entity2 @entity0 . The initial step of invasion is the degradation of extracellular matrix (ECM) by primary @entity2 cells in a tissue. Membranous metalloproteinase @entity5 and soluble metalloproteinase @entity4 are thought to play an important role in the degradation of ECM. In the previous report, we found that the repetitive insertion of @entity5 to invadopodia was crucial for the effective degradation of ECM (Hoshino, D., et al., PLoS Comp. Biol., 2012, e1002479). However, the role of @entity4 and the effect of inhibitors for these ECM-degrading proteases were still obscure. Here we investigated these two problems by using the same model as in the previous report. First we tested the effect of @entity4 and found that while @entity5 played a major role in the degradation of ECM, @entity4 played only a marginal effect on the degradation of ECM. Based on these findings, we next tested the effect of a putative inhibitor for @entity5 and found that such inhibitor was ineffective in blocking ECM degradation. Then we tested combined strategy including inhibitor for @entity5 , reduction of its turnover and its content in vesicles. A synergistic effect of combined strategy was observed in the decrease in the efficacy of ECM degradation. Our simulation study suggests the importance of combined strategy in blocking @entity2 invasion and @entity1 .

title: Synergistic effect of blocking XXXX cell invasion revealed by computer simulations.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ), the most lethal long-term complication of @entity3 ( @entity3 ), is the culmination of a complex sequence of molecular and histologic derangements of the colon epithelium that are initiated and at least partially sustained by @entity8 . @entity7 , the earliest histologic manifestation of this process, plays an important role in @entity1 prevention by providing the first clinical alert that this sequence is under way and by serving as an endpoint in colonoscopic surveillance of @entity0 at high risk for @entity2 . @entity9 ( @entity9 ) is indicated for @entity0 with @entity3 , specifically for @entity4 that is refractory to medical treatment, emergency conditions, and/or in case of @entity1 . Even after @entity9 with mucosectomy, pouch-related @entity5 have recently been reported with increasing frequency since the first report in 1984. We review @entity3 -associated @entity2 and pouch-related @entity1 prevalence, adverse events, risk factors, and surveillances. METHODS: Literature of @entity3 -associated @entity2 @entity0 and those undergoing @entity9 surgeries through 2010 were prospectively reviewed. RESULTS: We found 12 studies from retrospective series and 15 case reports. To date, there are 43 reported cases of pouch-related @entity1 . Thirty-two @entity0 had @entity1 in the anal transit zone ( @entity11 ); of these, 28 @entity0 had mucosectomy. Eleven @entity0 had @entity1 found in the pouch body. CONCLUSION: @entity9 with mucosectomy does not necessarily eliminate risks. There is little evidence to support routine surveillance of pouch mucosa and the ATZ except for @entity0 associated with histological type C changes, sclerosing @entity6 , and unremitting @entity10 .

title: XXXX : proctocolectomy and mucosectomy do not necessarily eliminate pouch-related @entity1 incidences.

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ), the most lethal long-term complication of @entity3 ( @entity3 ), is the culmination of a complex sequence of molecular and histologic derangements of the colon epithelium that are initiated and at least partially sustained by @entity8 . @entity7 , the earliest histologic manifestation of this process, plays an important role in @entity1 prevention by providing the first clinical alert that this sequence is under way and by serving as an endpoint in colonoscopic surveillance of @entity0 at high risk for @entity2 . @entity9 ( @entity9 ) is indicated for @entity0 with @entity3 , specifically for @entity4 that is refractory to medical treatment, emergency conditions, and/or in case of @entity1 . Even after @entity9 with mucosectomy, pouch-related @entity5 have recently been reported with increasing frequency since the first report in 1984. We review @entity3 -associated @entity2 and pouch-related @entity1 prevalence, adverse events, risk factors, and surveillances. METHODS: Literature of @entity3 -associated @entity2 @entity0 and those undergoing @entity9 surgeries through 2010 were prospectively reviewed. RESULTS: We found 12 studies from retrospective series and 15 case reports. To date, there are 43 reported cases of pouch-related @entity1 . Thirty-two @entity0 had @entity1 in the anal transit zone ( @entity11 ); of these, 28 @entity0 had mucosectomy. Eleven @entity0 had @entity1 found in the pouch body. CONCLUSION: @entity9 with mucosectomy does not necessarily eliminate risks. There is little evidence to support routine surveillance of pouch mucosa and the ATZ except for @entity0 associated with histological type C changes, sclerosing @entity6 , and unremitting @entity10 .

title: @entity2 : proctocolectomy and mucosectomy do not necessarily eliminate pouch-related XXXX incidences.

answer: @entity1


abstract: A heterogeneous population of ependymal cells lines the brain ventricles. The evidence about the origin and birth dates of these cell populations is scarce. Furthermore, the possibility that mature ependymal cells are born (ependymogenesis) or self-renewed (ependymal proliferation) postnatally is controversial. The present study was designed to investigate both phenomena in wild-type (wt) and hydrocephalic @entity5 mutant (hyh) @entity1 at different postnatal stages. In wt @entity1 , proliferating cells in the ventricular zone (VZ) were only found in two distinct regions: the dorsal walls of the third ventricle and Sylvian aqueduct (SA). Most proliferating cells were monociliated and nestin+, likely corresponding to radial glial cells. Postnatal cumulative @entity3 -labeling showed that most daughter cells remained in the VZ of both regions and they lost nestin-immunoreactivity. Furthermore, some labeled cells became multiciliated and @entity4 +, indicating they were ependymal cells born postnatally. Postnatal pulse @entity3 -labeling and Ki-67 immunostaining further demonstrated the presence of cycling multiciliated ependymal cells. In hydrocephalic mutants, the dorsal walls of the third ventricle and SA expanded enormously and showed neither ependymal disruption nor ventriculostomies. This phenomenon was sustained by an increased ependymogenesis. Consequently, in addition to the physical and geometrical mechanisms traditionally explaining ventricular enlargement in fetal-onset @entity2 , we propose that postnatal ependymogenesis could also play a role. Furthermore, as generation of new ependymal cells during postnatal stages was observed in distinct regions of the ventricular walls, such as the roof of the third ventricle, it may be a key mechanism involved in the development of @entity0 type 1 interhemispheric cysts.

title: New ependymal cells are born postnatally in two discrete regions of the @entity1 brain and support ventricular enlargement in XXXX .

answer: @entity2


abstract: A heterogeneous population of ependymal cells lines the brain ventricles. The evidence about the origin and birth dates of these cell populations is scarce. Furthermore, the possibility that mature ependymal cells are born (ependymogenesis) or self-renewed (ependymal proliferation) postnatally is controversial. The present study was designed to investigate both phenomena in wild-type (wt) and hydrocephalic @entity5 mutant (hyh) @entity1 at different postnatal stages. In wt @entity1 , proliferating cells in the ventricular zone (VZ) were only found in two distinct regions: the dorsal walls of the third ventricle and Sylvian aqueduct (SA). Most proliferating cells were monociliated and nestin+, likely corresponding to radial glial cells. Postnatal cumulative @entity3 -labeling showed that most daughter cells remained in the VZ of both regions and they lost nestin-immunoreactivity. Furthermore, some labeled cells became multiciliated and @entity4 +, indicating they were ependymal cells born postnatally. Postnatal pulse @entity3 -labeling and Ki-67 immunostaining further demonstrated the presence of cycling multiciliated ependymal cells. In hydrocephalic mutants, the dorsal walls of the third ventricle and SA expanded enormously and showed neither ependymal disruption nor ventriculostomies. This phenomenon was sustained by an increased ependymogenesis. Consequently, in addition to the physical and geometrical mechanisms traditionally explaining ventricular enlargement in fetal-onset @entity2 , we propose that postnatal ependymogenesis could also play a role. Furthermore, as generation of new ependymal cells during postnatal stages was observed in distinct regions of the ventricular walls, such as the roof of the third ventricle, it may be a key mechanism involved in the development of @entity0 type 1 interhemispheric cysts.

title: New ependymal cells are born postnatally in two discrete regions of the XXXX brain and support ventricular enlargement in @entity2 .

answer: @entity1


abstract: BACKGROUND: The aim of this study is to determine whether statistical associations can be demonstrated in @entity8 between baseline clinical and laboratory parameters with visual acuity at presentation and with any change in visual acuity after treatment. METHODS: Charts of 26 @entity0 (42 eyes) with @entity8 presenting to the @entity6 clinic of the Jules-Gonin Eye Hospital were reviewed. A baseline cross-sectional analysis was performed in order to identify any association between visual acuity at presentation and demographic, clinical or laboratory parameters. After treatment, any analogy between these parameters and a change in visual acuity was subsequently assessed in a series of univariate comparisons. RESULTS: The following factors were associated with worse initial visual acuity: severity of @entity4 at presentation (p=0.012), macular @entity1 (p=0.004) and @entity7 (p=0.031). There was a borderline association with the presence of @entity5 on fluroangiography (p=0.072). Improvement in best corrected visual acuity after treatment was significantly associated with the presence of @entity5 on fluroangiography (p=0.005), @entity9 , according to lumbar puncture findings (p=0.037) and marginally with anterior @entity6 (p=0.070). Inflammation relapse was associated with the coexistence of @entity3 as presenting sign (p<0.001) and with a longer duration of symptoms prior to the initial visit (p=0.023). CONCLUSIONS: Severe @entity2 associated with @entity5 , vitritis or anterior @entity6 in @entity8 would appear to be a reversible phenomenon that responds well to appropriate antibiotic treatment, resulting in improvement in visual acuity. Prompt treatment enables a good visual prognosis, while any delay in therapy increases the risk of subsequent relapse.

title: Analysis of significant factors influencing visual acuity in XXXX .

answer: @entity8


abstract: Several studies have investigated the orthonasal detection threshold for @entity2 ( @entity1 ) in @entity0 . The aim of current study was to investigate whether 24 healthy young subjects exhibited differences of @entity1 detection thresholds during orthonasal or retronasal stimulation. As nasal mucosa is believed to desensitize to @entity1 concentrations at or below 4% (v/v) during expiration, the second aim of the study was to explore the influence during nasal versus oral breathing on the detection thresholds. @entity1 stimuli of varying concentrations and a duration of 1000 ms were applied with an air-dilution olfactometer in either the anterior nasal cavity or the nasopharynx during nasal respectively oral breathing. In these 4 conditions, the mean @entity1 detection thresholds using the staircase forced-choice procedure were between 3.9% and 5.3% (v/v). Statistical analysis revealed a significant difference between orthonasal and retronasal stimulation. The @entity1 detection threshold was lower in retronasal stimulation. The nasopharyngeal mucosa is more sensitive to perithreshold @entity1 stimuli than the nasal mucosa. The breathing route had no influence on the detection thresholds. The results of this study indicate that the natural contact of the nasal mucosa with approximately 4% (v/v) @entity1 during nasal expiration does not influence @entity1 detection thresholds.

title: Comparison of the orthonasal and retronasal detection thresholds for XXXX in @entity0 .

answer: @entity2


abstract: Several studies have investigated the orthonasal detection threshold for @entity2 ( @entity1 ) in @entity0 . The aim of current study was to investigate whether 24 healthy young subjects exhibited differences of @entity1 detection thresholds during orthonasal or retronasal stimulation. As nasal mucosa is believed to desensitize to @entity1 concentrations at or below 4% (v/v) during expiration, the second aim of the study was to explore the influence during nasal versus oral breathing on the detection thresholds. @entity1 stimuli of varying concentrations and a duration of 1000 ms were applied with an air-dilution olfactometer in either the anterior nasal cavity or the nasopharynx during nasal respectively oral breathing. In these 4 conditions, the mean @entity1 detection thresholds using the staircase forced-choice procedure were between 3.9% and 5.3% (v/v). Statistical analysis revealed a significant difference between orthonasal and retronasal stimulation. The @entity1 detection threshold was lower in retronasal stimulation. The nasopharyngeal mucosa is more sensitive to perithreshold @entity1 stimuli than the nasal mucosa. The breathing route had no influence on the detection thresholds. The results of this study indicate that the natural contact of the nasal mucosa with approximately 4% (v/v) @entity1 during nasal expiration does not influence @entity1 detection thresholds.

title: Comparison of the orthonasal and retronasal detection thresholds for @entity2 in XXXX .

answer: @entity0


abstract: UNASSIGNED: Objectives Antimitochondrial antibodies (AMA) are a sensitive and specific marker for @entity3 ( @entity3 ). AMAs are present in 95% of @entity0 with @entity3 . However, 5% do not have AMAs and data on these @entity0 is scarce. We aim to evaluate the long-term outcomes of @entity0 with AMA negative @entity3 . Methods A retrospective chart review of 71 AMA negative @entity3 @entity0 . Disease presentation, laboratory results, and clinical endpoints were recorded. AMA negative @entity0 were matched on year of diagnosis to a control group of 71 AMA positive @entity0 . Results Ninety-six percent of the AMA negative @entity0 were of female gender with a median age at diagnosis of 55 years and a length of follow-up of 7.5 years vs. 86% females, a median age of 56 and a follow-up of 8.3 years in the control group. Mean total @entity2 and alkaline phosphatase levels were 0.7   mg/dL vs. 0.6 and 570   U/L vs 341, in AMA negative vs. AMA positive @entity0 at presentation, respectively (p   =   NS). AMA negative @entity0 did not differ in terms of age, serum IgM levels, ANA status, or length of follow-up. Notably, AMA negative @entity0 had a significantly reduced survival free of liver-related complications including transplantation and @entity1 compared to AMA positive @entity0 (p   =   0.0182). Conclusion In this large experience, AMA negative @entity3 @entity0 had a significantly worse prognosis compared to AMA positive @entity3 @entity0 . The reason for the difference in prognosis is unclear, as it may be true difference or reflect delays in case detection among AMA negative @entity0 .

title: Long-term outcomes in antimitochondrial antibody negative XXXX .

answer: @entity3


abstract: BACKGROUND: @entity0 with @entity1 ( @entity1 ) may develop several gait disturbances during the @entity2 and Freezing of gait ( @entity4 ) is one of them. Several neuroimaging studies have been conducted to identify the neural correlates of @entity4 but results have not been uniform. Resting state functional MRI (rs-fMRI) is relatively less explored in @entity1 @entity0 with @entity4 . This study aims to compare the whole brain resting state connectivity of @entity1 @entity0 with and without @entity4 using rs-fMRI. METHODS: rs-fMRI was obtained for 28 @entity1 @entity0 (15 with and 13 @entity0 without @entity4 ) who were matched for various demographic and clinical characteristics. Seed to voxel analysis was performed at whole brain level and compared between the two groups. RESULTS: When compared to @entity0 without @entity4 , the @entity0 with @entity4 had reduced functional connectivity across multiple seeds. Major finding was reduced inter-hemispheric connectivity of left parietal opercular cortex with multiple regions of the brain primarily involving the primary @entity3 , which also negatively correlated with the FOGQ scores. CONCLUSION: Our findings suggest that alterations in the resting state functional connectivity of the opercular parietal cortex may be one of the substrates of @entity4 . Reduced interhemispheric connectivity probably is the reason for impairment of control and coordination in bilateral leg movements while walking.

title: Freezing of gait in XXXX is associated with altered functional brain connectivity.

answer: @entity1


abstract: BACKGROUND: A @entity0 with unresectable periampullary malignancy found at laparotomy has traditionally  received a prophylactic double bypass (biliary and duodenal), associated with considerable morbidity. With modern endoscopic treatments, surgical bypass has become questionable. This study aims to compare the two strategies. Sahlgrenska University Hospital (SU) performs a double bypass (DoB) routinely, and Sk  ne University Hospital Lund (SUL) secures biliary drainage endoscopically and treats only symptomatic @entity3 (Wait and See, WaS). METHOD: Between 2004 and 2013, 73 @entity0 from SU and 70 from SUL were retrospectively identified. Demographics, @entity1 -related factors and postoperative outcomes during the remaining lifetime were noted. RESULTS: The DoB group had significantly more complications (67% vs. 31%, p  =  0.00002) and longer hospital stay (14 vs. 8 days, p  =  0.001) than the WaS-group. The two groups had similar proportion of @entity0 in need of readmission. The DoB @entity0 and the WaS @entity0 with metallic biliary stents were comparable regarding their need of re-interventions and hospitalisation due to @entity2 . Surgical  duodenal bypass did not prevent future @entity3 . CONCLUSION: @entity0 with unresectable periampullary malignancies can safely be managed with endoscopic drainage on demand and with lower morbidity and shorter hospital stay than with surgical prophylactic bypass.

title: A wait-and-see strategy with subsequent self-expanding metal stent on demand is superior to prophylactic bypass surgery for unresectable XXXX .

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to investigate outcomes of @entity0 treated with endovascular repair (ER) with the use of fenestrated and branched stent grafts or @entity9 ( @entity9 ) for @entity11 ( @entity11 ) in a current series of @entity0 . METHODS: All @entity11 @entity0 undergoing repair at three centers between January 2007 and December 2014 were included in a prospective database. @entity0 were stratified according to treatment by ER or @entity9 , and outcomes were compared using propensity score matching (1:1). Covariates included age, sex, @entity7 extent, @entity2 , @entity5 , @entity6 , @entity1 , and renal function. The primary end points were mortality and @entity8 . Secondary end points included any @entity12 ( @entity12 ), @entity3 , and a composite of these complications or @entity4 at 30  days. All-cause survival and freedom from reintervention were compared in the two groups. RESULTS: Of 341 @entity0 , 84 (25%) underwent ER and 257 underwent @entity9 (75%). After propensity score matching (65 @entity0 per group), no significant differences were observed in rates of 30-day mortality (7.7% in ER and 6.2% in @entity9 ; P  = 1) and @entity8 (9.2% and 10.8%; P  = 1). Any @entity12 , @entity3 , and @entity10 were 12.3% and 20% (P  = .34), 9.2% and 12.3% (P  = .78), and 0% and 12.3% (P  = .006) in ER and @entity9 , respectively. The incidence of the composite end point was significantly lower in ER @entity0 (18.5% in ER vs 36.0% in @entity9 ; P  =.03). According to Kaplan-Meier estimates, all-cause survival at 24  months was 82.8% in ER and 84.9% in @entity9 , with rates unchanged at 42  months (P  = .9). Rates of freedom from reintervention were 91.0% vs 89.7% at 24  months and 80.0% vs 79.9% at 42  months in ER vs @entity9 , respectively (P  = .3). CONCLUSIONS: A propensity score analysis in @entity0 with @entity11 undergoing repair suggests an early benefit from ER compared with @entity9 with regard to the composite end point because of reduced 30-day respiratory complications. No significant differences were found in @entity12 and @entity3 at 30  days and in survival and reintervention rates at midterm.

title: A propensity-matched comparison for endovascular and open repair of XXXX .

answer: @entity11


abstract: BACKGROUND: In aging, a host of molecular and cellular changes occur which accelerate alteration and progression of @entity1 . These conditions in the elderly @entity0 cause appearance of a phenomenon which has been denoted as "inflammaging". Understanding the pathogenesis and finding new methods for management of inflammaging are essential. PURPOSE: In this paper we tried not only to explain inflammaging and its treatments with concentrating on medical plants but to collect a sufficient collection of anti-inflammatory plants with focusing on their mechanism of action. METHOD: In this review paper, by searching in indexing cites, desired articles were obtained since 1995 by using keywords of @entity1 , inflammaging, @entity1 pathophysiology, free radicals and @entity1 , aging @entity1 , @entity1 , and plants or herbal medicine in @entity1 . SECTIONS: In advanced age the generation of free radicals @entity2 . @entity1 is also associated with production of excess free radicals More importantly, chronic @entity1 makes aged @entity0 susceptible to age-related diseases. Some medicinal plants have been shown promising results in inhibition of inflammaging. Some other sections such as @entity1 and inflammaging in @entity2 , oxidative stress in @entity2 , prevention and treatment strategies are presented. CONCLUSION: The results of published papers show that the symptoms of several @entity1 can be inhibited or treated by active ingredients from medicinal plants.

title: Inflammaging and XXXX : Management by medicinal plants.

answer: @entity2


abstract: UNASSIGNED: Contrast-enhanced ultrasound of the spleen enables the dynamic assessment of the perfusion of this organ, however, both subjective and quantitative evaluation can be strongly influenced by sedative agent administration. The purpose of this prospective, experimental study was to test effects of two sedative agents on splenic perfusion during contrast-enhanced ultrasound of the spleen in a sample of healthy @entity0 . Contrast-enhanced ultrasound of the spleen was repeated in six healthy Beagles following a cross-over study design comparing three protocols: awake, @entity5 0.2 mg/Kg intramuscular (IM), and @entity3 500  g/m(2) IM. After intravenous injection of a phospholipid stabilized @entity4 microbubble solution ( @entity6  , Bracco Imaging, Milano, Italy), the enhancement intensity and perfusion pattern of the splenic parenchyma were assessed and perfusion parameters were calculated. Normal spleen was slightly heterogeneous in the early phase, but the parenchyma was homogeneous at a later phase. Sedation with @entity5 did not modify perfusion of the spleen. @entity3 significantly reduced splenic enhancement, providing diffuse parenchymal hypoechogenicity during the entire examination. Measured parameters were significantly modified, with increased @entity1 ( @entity2 ; ( < 0.0001) and @entity1 ( @entity1 ; P < 0.0001), and decreased peak intensity (PI; P = 0.0108), wash-in (P = 0.0014), and area under the curve (AUC; P = 0.0421). Findings supported the use of @entity5 and contraindicated the use of @entity3 as sedatives for splenic contrast ultrasound procedures in @entity0 . Short-term and diffuse heterogeneity of the spleen in the early venous phase was determined to be a normal finding.

title: EFFECT OF SEDATION ON CONTRAST-ENHANCED ULTRASONOGRAPHY OF THE SPLEEN IN HEALTHY XXXX .

answer: @entity0


abstract: INTRODUCTION: @entity1 may play a role in velopharyngeal closure especially in @entity0 with palatal abnormality; adenoidectomy may lead to @entity3 and hyper nasal speech. @entity0 with @entity4 even after repair should not undergo adenoidectomy unless absolutely needed, and in such situations, conservative or partial adenoidectomy is performed to avoid the occurrence of @entity3 . Trans-oral endoscopic adenoidectomy enables the surgeon to inspect the velopharyngeal valve during the procedure. OBJECTIVE: The aim of this study was to assess the effect of transoral endoscopic partial adenoidectomy on the speech of @entity0 with repaired @entity4 . METHODS: Twenty @entity0 with repaired @entity4 underwent transoral endoscopic partial adenoidectomy to relieve their @entity2 . The procedure was completely visualized with the use of a 70   4mm nasal endoscope; the upper part of the adenoid was removed using adenoid curette and St. Claire Thompson forceps, while the lower part was retained to maintain the velopharyngeal competence. Preoperative and postoperative evaluation of speech was performed, subjectively by auditory perceptual assessment, and objectively by nasometric assessment. RESULTS: Speech was not adversely affected after surgery. The difference between preoperative and postoperative auditory perceptual assessment and nasalance scores for nasal and oral sentences was insignificant (p=0.231, 0.442, 0.118 respectively). CONCLUSIONS: Transoral endoscopic partial adenoidectomy is a safe method; it does not worsen the speech of repaired @entity4 @entity0 . It enables the surgeon to strictly inspect the velopharyngeal valve during the procedure with better determination of the adenoidal part that may contribute in velopharyngeal closure.

title: Trans-oral endoscopic partial adenoidectomy does not worsen the speech after XXXX repair.

answer: @entity4


abstract: UNASSIGNED: @entity7 , a major @entity6 family kinase (SFK) member that is densely expressed in striatal neurons, is actively involved in the regulation of cellular and synaptic activities in local neurons. This SFK member is likely regulated by @entity1 signaling through a receptor mechanism involving @entity1 D2 receptors (D2Rs). This study characterizes the D2R-dependent regulation of @entity7 in the @entity0 striatum in vivo. Moreover, we explore whether D2Rs regulate metabotropic @entity2 receptor 5 ( @entity4 ) in its @entity3 phosphorylation and whether the D2R-SFK pathway modulates trafficking of @entity4 . We found that blockade of D2Rs by systemic administration of a D2R antagonist, @entity5 , substantially increased SFK phosphorylation in the striatum. This increase was a transient and reversible event. The @entity5 -induced SFK phosphorylation occurred predominantly in immunopurified @entity7 but not in another SFK member, @entity6 . @entity5 also elevated @entity3 phosphorylation of @entity4 . In parallel, @entity5 enhanced synaptic delivery of active @entity7 and @entity4 . Pretreatment with an SFK inhibitor blocked the @entity5 -induced @entity3 phosphorylation and synaptic trafficking of @entity4 . These results indicate that D2Rs inhibit SFK (mainly @entity7 ) phosphorylation in the striatum. D2Rs also inhibit @entity3 phosphorylation and synaptic recruitment of @entity4 through a signaling mechanism likely involving @entity7 .    2016 Wiley Periodicals, Inc.

title: @entity1 D2 receptors are involved in the regulation of @entity7 and metabotropic XXXX receptor 5 phosphorylation in the @entity0 striatum in vivo.

answer: @entity2


abstract: UNASSIGNED: @entity7 , a major @entity6 family kinase (SFK) member that is densely expressed in striatal neurons, is actively involved in the regulation of cellular and synaptic activities in local neurons. This SFK member is likely regulated by @entity1 signaling through a receptor mechanism involving @entity1 D2 receptors (D2Rs). This study characterizes the D2R-dependent regulation of @entity7 in the @entity0 striatum in vivo. Moreover, we explore whether D2Rs regulate metabotropic @entity2 receptor 5 ( @entity4 ) in its @entity3 phosphorylation and whether the D2R-SFK pathway modulates trafficking of @entity4 . We found that blockade of D2Rs by systemic administration of a D2R antagonist, @entity5 , substantially increased SFK phosphorylation in the striatum. This increase was a transient and reversible event. The @entity5 -induced SFK phosphorylation occurred predominantly in immunopurified @entity7 but not in another SFK member, @entity6 . @entity5 also elevated @entity3 phosphorylation of @entity4 . In parallel, @entity5 enhanced synaptic delivery of active @entity7 and @entity4 . Pretreatment with an SFK inhibitor blocked the @entity5 -induced @entity3 phosphorylation and synaptic trafficking of @entity4 . These results indicate that D2Rs inhibit SFK (mainly @entity7 ) phosphorylation in the striatum. D2Rs also inhibit @entity3 phosphorylation and synaptic recruitment of @entity4 through a signaling mechanism likely involving @entity7 .    2016 Wiley Periodicals, Inc.

title: XXXX D2 receptors are involved in the regulation of @entity7 and metabotropic @entity2 receptor 5 phosphorylation in the @entity0 striatum in vivo.

answer: @entity1


abstract: UNASSIGNED: @entity7 , a major @entity6 family kinase (SFK) member that is densely expressed in striatal neurons, is actively involved in the regulation of cellular and synaptic activities in local neurons. This SFK member is likely regulated by @entity1 signaling through a receptor mechanism involving @entity1 D2 receptors (D2Rs). This study characterizes the D2R-dependent regulation of @entity7 in the @entity0 striatum in vivo. Moreover, we explore whether D2Rs regulate metabotropic @entity2 receptor 5 ( @entity4 ) in its @entity3 phosphorylation and whether the D2R-SFK pathway modulates trafficking of @entity4 . We found that blockade of D2Rs by systemic administration of a D2R antagonist, @entity5 , substantially increased SFK phosphorylation in the striatum. This increase was a transient and reversible event. The @entity5 -induced SFK phosphorylation occurred predominantly in immunopurified @entity7 but not in another SFK member, @entity6 . @entity5 also elevated @entity3 phosphorylation of @entity4 . In parallel, @entity5 enhanced synaptic delivery of active @entity7 and @entity4 . Pretreatment with an SFK inhibitor blocked the @entity5 -induced @entity3 phosphorylation and synaptic trafficking of @entity4 . These results indicate that D2Rs inhibit SFK (mainly @entity7 ) phosphorylation in the striatum. D2Rs also inhibit @entity3 phosphorylation and synaptic recruitment of @entity4 through a signaling mechanism likely involving @entity7 .    2016 Wiley Periodicals, Inc.

title: @entity1 D2 receptors are involved in the regulation of XXXX and metabotropic @entity2 receptor 5 phosphorylation in the @entity0 striatum in vivo.

answer: @entity7


abstract: UNASSIGNED: @entity7 , a major @entity6 family kinase (SFK) member that is densely expressed in striatal neurons, is actively involved in the regulation of cellular and synaptic activities in local neurons. This SFK member is likely regulated by @entity1 signaling through a receptor mechanism involving @entity1 D2 receptors (D2Rs). This study characterizes the D2R-dependent regulation of @entity7 in the @entity0 striatum in vivo. Moreover, we explore whether D2Rs regulate metabotropic @entity2 receptor 5 ( @entity4 ) in its @entity3 phosphorylation and whether the D2R-SFK pathway modulates trafficking of @entity4 . We found that blockade of D2Rs by systemic administration of a D2R antagonist, @entity5 , substantially increased SFK phosphorylation in the striatum. This increase was a transient and reversible event. The @entity5 -induced SFK phosphorylation occurred predominantly in immunopurified @entity7 but not in another SFK member, @entity6 . @entity5 also elevated @entity3 phosphorylation of @entity4 . In parallel, @entity5 enhanced synaptic delivery of active @entity7 and @entity4 . Pretreatment with an SFK inhibitor blocked the @entity5 -induced @entity3 phosphorylation and synaptic trafficking of @entity4 . These results indicate that D2Rs inhibit SFK (mainly @entity7 ) phosphorylation in the striatum. D2Rs also inhibit @entity3 phosphorylation and synaptic recruitment of @entity4 through a signaling mechanism likely involving @entity7 .    2016 Wiley Periodicals, Inc.

title: @entity1 D2 receptors are involved in the regulation of @entity7 and metabotropic @entity2 receptor 5 phosphorylation in the XXXX striatum in vivo.

answer: @entity0


abstract: OBJECTIVES: This study sought to evaluate the diagnostic performance of optical frequency domain imaging (OFDI) for recognition of coronary plaque morphologies and to assess additive values of integrated backscatter intravascular ultrasound (IB-IVUS) in detection of vulnerable plaque. BACKGROUND: Precise diagnosis of @entity2 susceptible to @entity3 and @entity4 may serve to stratify the risk of future coronary events and to make decisions for appropriate treatment of choice. METHODS: Twenty-seven coronary arteries from 14 @entity0 autopsy hearts were interrogated ex  vivo by OFDI and IB-IVUS. Imaged segments were sectioned at 3 mm intervals where a total of 360 pairs of cross-sectional images coregistered to histology were investigated. RESULTS: Overall, OFDI could depict various plaque components and structures such as fibrous tissue, sheet and nodular calcification, lipid, @entity1 crystals, and healed @entity3 . OFDI could detect 14 of 18 thin-cap @entity5 (TCFA), however, the diagnostic accuracy was not high (positive predictive value [ @entity6 ]  = 60.9%, k  =  0.664; area under the curve [AUC]: 0.88) mainly because of signal interference from macrophages. Further, we defined IB-IVUS-derived TCFA by recursive partitioning analysis as: 1) cross-sectional % lipid area >65.1%; 2) % lipid  area >32.3 but  <65.1% with plaque area >10.5 mm(2), where TCFA detection by IB-IVUS alone was marginal ( @entity6  =  50.0%, k  = 0.545; AUC: 0.82). However, when IB-IVUS was combined with OFDI, all pseudo OFDI-derived TCFA (non-TCFA on histology) were excluded. Accordingly, @entity6 of TCFAs diagnosed by both OFDI and IB-IVUS was improved to 100.0% (k  = 0.704; AUC: 0.93). CONCLUSIONS: OFDI could recognize detailed morphologies of @entity0 coronary plaque. However, diagnostic accuracy of both OFDI alone and IB-IVUS alone to identify TCFA is limited. Combination of IB-IVUS with OFDI improved the accuracy for TCFA detection, suggesting hybrid imaging or further development of novel devices will be required to identify @entity2 responsible for future events.

title: Additive Value of Integrated Backscatter IVUS for Detection of Vulnerable Plaque by Optical Frequency Domain Imaging: An Ex  Vivo Autopsy Study of XXXX Coronary Arteries.

answer: @entity0


abstract: This study reports that treatment of @entity1 with different growth factors initiates distinct rates of repair. We developed a new method for monitoring the progression of repair, based upon measuring the in vivo mechanical properties of healing bone. Two different members of the bone morphogenetic protein (BMP) family were chosen to initiate defect healing: @entity2 to induce osteogenesis, and @entity4 to induce chondrogenesis. To evaluate bone healing, BMPs were implanted into stabilised 5  mm bone defects in @entity0 femurs and compared to controls. During the first two weeks, in vivo biomechanical measurements showed similar values regardless of the treatment used. However, 2 weeks after surgery, the rhBMP-2 group had a substantial increase in stiffness, which was supported by the imaging modalities. Although the rhGDF-5 group showed comparable mechanical properties at 6 weeks as the rhBMP-2 group, the temporal development of regenerating tissues appeared different with rhGDF-5, resulting in a smaller callus and delayed tissue mineralisation. Moreover, histology showed the presence of cartilage in the rhGDF-5 group whereas the rhBMP-2 group had no cartilaginous tissue. Therefore, this study shows that rhBMP-2 and rhGDF-5 treated defects, under the same conditions, use distinct rates of bone healing as shown by the tissue mechanical properties. Furthermore, results showed that in vivo biomechanical method is capable of detecting differences in healing rate by means of change in @entity3 due to tissue mineralisation.

title: Time kinetics of bone defect healing in response to @entity2 and XXXX characterised by in vivo biomechanics.

answer: @entity4


abstract: This study reports that treatment of @entity1 with different growth factors initiates distinct rates of repair. We developed a new method for monitoring the progression of repair, based upon measuring the in vivo mechanical properties of healing bone. Two different members of the bone morphogenetic protein (BMP) family were chosen to initiate defect healing: @entity2 to induce osteogenesis, and @entity4 to induce chondrogenesis. To evaluate bone healing, BMPs were implanted into stabilised 5  mm bone defects in @entity0 femurs and compared to controls. During the first two weeks, in vivo biomechanical measurements showed similar values regardless of the treatment used. However, 2 weeks after surgery, the rhBMP-2 group had a substantial increase in stiffness, which was supported by the imaging modalities. Although the rhGDF-5 group showed comparable mechanical properties at 6 weeks as the rhBMP-2 group, the temporal development of regenerating tissues appeared different with rhGDF-5, resulting in a smaller callus and delayed tissue mineralisation. Moreover, histology showed the presence of cartilage in the rhGDF-5 group whereas the rhBMP-2 group had no cartilaginous tissue. Therefore, this study shows that rhBMP-2 and rhGDF-5 treated defects, under the same conditions, use distinct rates of bone healing as shown by the tissue mechanical properties. Furthermore, results showed that in vivo biomechanical method is capable of detecting differences in healing rate by means of change in @entity3 due to tissue mineralisation.

title: Time kinetics of bone defect healing in response to XXXX and @entity4 characterised by in vivo biomechanics.

answer: @entity2


abstract: @entity1 among @entity3 @entity0 have been consistently documented in research over the past 20 years and are reviewed in this chapter. Discussion of general abilities is presented as a background and is followed by analysis of functioning in specific cognitive domains. Overall intellectual deficits are indicated by results from both general intelligence tests and composite test battery scores. Within specific cognitive domains, effect size differences are noted in numerous areas, including attention, with indications that working memory is affected more severely than simple attention, likely due to inclusion of an executive component in such tasks. There is also evidence of slowed processing speed among @entity3 @entity0 , likely contributing to deficits in other domains which rely on rapid and efficient assimilation of information. @entity2 have been found on tests assessing set-shifting abilities, selective attention, and inhibition of inappropriate responses. @entity4 have been demonstrated extensively, with some evidence that recall of verbal material is more affected than recall of visual information, and that recognition abilities are comparatively less impaired than recall for both modalities. Receptive and expressive language abilities are compromised in @entity3 @entity0 , as well as visual perceptual, constructional, and fine motor skills. Social cognition is an area of particular importance due to its relevance to functional outcome. Deficits in expression and recognition of facial and prosodic affect have been demonstrated, although subjective experience of emotion appears to be relatively well preserved. @entity1 described in this review appear to generally remain stable throughout adulthood, supporting neurodevelopmental, rather than neurodegenerative, models of the illness. Finally, @entity2 are increasingly used as endophenotypes, which is likely an important direction of future research.

title: Neurocognition in XXXX .

answer: @entity3


abstract: OBJECTIVE: To provide an updated review on the clinical experience in laparoscopic liver resection, specifically for @entity2 . METHODS: A comprehensive literature search in MEDLINE was conducted for all English papers up to May 2010 on laparoscopic liver resection for @entity2 . @entity0 characteristics, perioperative results, and oncologic outcomes were compared and analysed. RESULTS: We analysed 11 clinical studies involving 466 @entity2 @entity0 treated with laparoscopic hepatectomy. Thirty-seven (9%) @entity0 underwent major resection. @entity1 occurred in 62%. The mean operative time was 189.5 min, and the mean @entity3 was 315.6 mL. Blood transfusion was required in 14.6% of @entity0 . There were two operative deaths. @entity4 included @entity7 (1%), @entity5 (2.9%), @entity8 (5.1%), and @entity6 (6%). The 1-year, 3-year, and 5-year disease-free survival rates ranged from 60% to 90%, 50% to 64%, and 31% to 50%, respectively, and the corresponding overall survival rates ranged from 85% to 100%, 67% to 100%, and 50% to 97% respectively. CONCLUSION: Laparoscopic liver resection for @entity2 appears to be safe and to achieve acceptable oncologic outcomes even in cirrhotic livers, but whether it is comparable to conventional open surgery needs to be evaluated in a randomized, controlled trial setting.

title: Laparoscopic liver resection for XXXX .

answer: @entity2


abstract: Due to the wide range of pesticides that can be used in agriculture, the development of fast multiresidue methods that simultaneously determine polar and non-polar pesticides is greatly demanded. This study shows the development and validation of a multiresidue method for the analysis of 98 non-polar pesticides and 28 polar pesticides in soil. A simultaneous extraction step by pressurized liquid extraction was utilized. The optimum results were obtained using @entity2 - @entity1 (3:1, v/v) with 2 min of preheat time and 85 degrees C as the extraction temperature. The final determination of non-polar pesticides was performed by GC, whereas polar pesticides were determined by ultra-performance liquid chromatography (UPLC). Both GC and UPLC were coupled to triple-quadrupole analyzers operating in tandem @entity0 . The optimized extraction procedure was validated. The average extraction recoveries were in the range 72-108% (10 microg/kg) and 71-106% (50 microg/kg), with RSD values < or = 26%. The matrix effect was also evaluated, and matrix-matched standard calibration was finally applied for quantification. The suitability of the method was also checked by the analysis of a certified reference material. Furthermore, 26 real soil samples were analyzed by the proposed methods in order to assess their applicability. Several pesticides (e.g., @entity4 , @entity5 , or @entity3 ) were found in the samples.

title: Use of pressurized liquid extraction for the simultaneous analysis of 28 polar and 94 non-polar pesticides in agricultural soils by GC/QqQ- @entity0 / XXXX and UPLC/QqQ- @entity0 / @entity0 .

answer: @entity0


abstract: Due to the wide range of pesticides that can be used in agriculture, the development of fast multiresidue methods that simultaneously determine polar and non-polar pesticides is greatly demanded. This study shows the development and validation of a multiresidue method for the analysis of 98 non-polar pesticides and 28 polar pesticides in soil. A simultaneous extraction step by pressurized liquid extraction was utilized. The optimum results were obtained using @entity2 - @entity1 (3:1, v/v) with 2 min of preheat time and 85 degrees C as the extraction temperature. The final determination of non-polar pesticides was performed by GC, whereas polar pesticides were determined by ultra-performance liquid chromatography (UPLC). Both GC and UPLC were coupled to triple-quadrupole analyzers operating in tandem @entity0 . The optimized extraction procedure was validated. The average extraction recoveries were in the range 72-108% (10 microg/kg) and 71-106% (50 microg/kg), with RSD values < or = 26%. The matrix effect was also evaluated, and matrix-matched standard calibration was finally applied for quantification. The suitability of the method was also checked by the analysis of a certified reference material. Furthermore, 26 real soil samples were analyzed by the proposed methods in order to assess their applicability. Several pesticides (e.g., @entity4 , @entity5 , or @entity3 ) were found in the samples.

title: Use of pressurized liquid extraction for the simultaneous analysis of 28 polar and 94 non-polar pesticides in agricultural soils by GC/QqQ- XXXX / @entity0 and UPLC/QqQ- @entity0 / @entity0 .

answer: @entity0


abstract: Due to the wide range of pesticides that can be used in agriculture, the development of fast multiresidue methods that simultaneously determine polar and non-polar pesticides is greatly demanded. This study shows the development and validation of a multiresidue method for the analysis of 98 non-polar pesticides and 28 polar pesticides in soil. A simultaneous extraction step by pressurized liquid extraction was utilized. The optimum results were obtained using @entity2 - @entity1 (3:1, v/v) with 2 min of preheat time and 85 degrees C as the extraction temperature. The final determination of non-polar pesticides was performed by GC, whereas polar pesticides were determined by ultra-performance liquid chromatography (UPLC). Both GC and UPLC were coupled to triple-quadrupole analyzers operating in tandem @entity0 . The optimized extraction procedure was validated. The average extraction recoveries were in the range 72-108% (10 microg/kg) and 71-106% (50 microg/kg), with RSD values < or = 26%. The matrix effect was also evaluated, and matrix-matched standard calibration was finally applied for quantification. The suitability of the method was also checked by the analysis of a certified reference material. Furthermore, 26 real soil samples were analyzed by the proposed methods in order to assess their applicability. Several pesticides (e.g., @entity4 , @entity5 , or @entity3 ) were found in the samples.

title: Use of pressurized liquid extraction for the simultaneous analysis of 28 polar and 94 non-polar pesticides in agricultural soils by GC/QqQ- @entity0 / @entity0 and UPLC/QqQ- XXXX / @entity0 .

answer: @entity0


abstract: Due to the wide range of pesticides that can be used in agriculture, the development of fast multiresidue methods that simultaneously determine polar and non-polar pesticides is greatly demanded. This study shows the development and validation of a multiresidue method for the analysis of 98 non-polar pesticides and 28 polar pesticides in soil. A simultaneous extraction step by pressurized liquid extraction was utilized. The optimum results were obtained using @entity2 - @entity1 (3:1, v/v) with 2 min of preheat time and 85 degrees C as the extraction temperature. The final determination of non-polar pesticides was performed by GC, whereas polar pesticides were determined by ultra-performance liquid chromatography (UPLC). Both GC and UPLC were coupled to triple-quadrupole analyzers operating in tandem @entity0 . The optimized extraction procedure was validated. The average extraction recoveries were in the range 72-108% (10 microg/kg) and 71-106% (50 microg/kg), with RSD values < or = 26%. The matrix effect was also evaluated, and matrix-matched standard calibration was finally applied for quantification. The suitability of the method was also checked by the analysis of a certified reference material. Furthermore, 26 real soil samples were analyzed by the proposed methods in order to assess their applicability. Several pesticides (e.g., @entity4 , @entity5 , or @entity3 ) were found in the samples.

title: Use of pressurized liquid extraction for the simultaneous analysis of 28 polar and 94 non-polar pesticides in agricultural soils by GC/QqQ- @entity0 / @entity0 and UPLC/QqQ- @entity0 / XXXX .

answer: @entity0


abstract: PURPOSE: To evaluate the effects of current hygiene standards for the enucleation of postmortem eyes by investigating the number of microorganisms during subsequent steps of decontamination and tissue processing. MATERIALS AND METHODS: This prospective, non-randomized cohort study includes 184 postmortem eyes of 92 @entity0 donors. Enucleation was performed, according to an ophthalmic surgical procedure. Two groups were generated as follows: right eyes were allocated to group A, left eyes were allocated to group B. In group A, a @entity1 was used accessorily. Conjunctival smears were taken to examine germ load in both groups before any intervention, in group A after @entity1 , in both groups after transportation of the whole globes in transport fluid, and in both groups after a bath in 0.75% @entity4 solution for at least 3 minutes just before preparation of the @entity3 . Smears were sent to the local microbiologic laboratory in an aseptic package for testing. RESULTS: All smears showed multiple contaminations (n = 184/184 eyes) before treatment with @entity4 solution. Contamination was in both groups significantly prevented using the treatment strategy of an at least 3-minute bath in 0.75% @entity4 solution (n = 1/184 eyes; p < 0.01) As a side effect, almost every eye of group A and none of group B showed brown @entity2 staining corresponding to corneal epithelial erosion. CONCLUSIONS: An aseptic setting for donor enucleation similar to a surgical procedure seems not to influence the outcome of germ colonization. The most effective step to decontaminate donor eyes is to use 0.75% @entity4 solution for at least 3 minutes.

title: Comparing Different Decontamination Procedures in Harvesting XXXX Donor Cornea.

answer: @entity0


abstract: OBJECTIVES: Tonsil and adenoid are part of waldeyers ring; the basic function of which are antibody formation, which later react against a grat variety of antigens. The Adenotonsillectomy is the most common operation in small @entity0 but the exact reasons of @entity3 remains unknown, some researches have shown that @entity2 may be at risk factor for @entity3 . METHODS: Thorough one year two separated groups of @entity0 at the ENT and @entity2 ward of childrens hospital was enrolled in the study. The study group consisted of 117 @entity0 between 1 and 14 years old (with average of 6) who had @entity3 . The control group consisted of 100 @entity0 in the similar age that had not @entity3 . Both groups were examined for the incidence of @entity1 , results of skin prick test, serum @entity4 levels and close contact to smoke. RESULTS: In the study group 70.3% of @entity0 with @entity3 had positive skin prick test. But only 10% of @entity0 in control group had positive skin prick test. Increased serum total @entity4 level was confirmed in 48% of @entity0 with positive skin prick test in study group were in close contact with smoker parents. CONCLUSION: @entity2 and sensitivity to different kinds of allergens are important risk factors for @entity3 in @entity0 . @entity2 control may have role in reducing the rate of adenotonsillectomy in @entity0 suffering @entity1 with @entity3 .

title: Is there any correlation between @entity2 and adenotonsillar tissue XXXX ?

answer: @entity3


abstract: OBJECTIVES: Tonsil and adenoid are part of waldeyers ring; the basic function of which are antibody formation, which later react against a grat variety of antigens. The Adenotonsillectomy is the most common operation in small @entity0 but the exact reasons of @entity3 remains unknown, some researches have shown that @entity2 may be at risk factor for @entity3 . METHODS: Thorough one year two separated groups of @entity0 at the ENT and @entity2 ward of childrens hospital was enrolled in the study. The study group consisted of 117 @entity0 between 1 and 14 years old (with average of 6) who had @entity3 . The control group consisted of 100 @entity0 in the similar age that had not @entity3 . Both groups were examined for the incidence of @entity1 , results of skin prick test, serum @entity4 levels and close contact to smoke. RESULTS: In the study group 70.3% of @entity0 with @entity3 had positive skin prick test. But only 10% of @entity0 in control group had positive skin prick test. Increased serum total @entity4 level was confirmed in 48% of @entity0 with positive skin prick test in study group were in close contact with smoker parents. CONCLUSION: @entity2 and sensitivity to different kinds of allergens are important risk factors for @entity3 in @entity0 . @entity2 control may have role in reducing the rate of adenotonsillectomy in @entity0 suffering @entity1 with @entity3 .

title: Is there any correlation between XXXX and adenotonsillar tissue @entity3 ?

answer: @entity2


abstract: BACKGROUND: Treatment of @entity1 with @entity2 deprivation therapy (ADT) is associated with metabolic changes that have been linked to an increase in cardiovascular risk. METHODS: This randomised controlled trial investigated the effects of a 12-week lifestyle intervention that included supervised exercise training and dietary advice on markers of cardiovascular risk in 50 @entity0 on long-term ADT recruited to an on-going study investigating the effects of such a lifestyle intervention on quality of life. @entity0 were randomly allocated to receive the intervention or usual care. Cardiovascular outcomes included endothelial function ( @entity3 ( @entity3 ) of the brachial artery), blood pressure, body composition and serum lipids. Additional outcomes included treadmill walk time and exercise and dietary behaviours. Outcomes were assessed before randomisation (baseline), and 6, 12 and 24 weeks after randomisation. RESULTS: At 12 weeks, the difference in mean relative @entity3 was 2.2% (95% confidence interval (CI) 0.1-4.3, P=0.04) with an effect size of 0.60 (95% CI <0.01-1.18) favouring the intervention group. Improvements in skeletal muscle mass, treadmill walk time and exercise behaviour also occurred in the intervention group over that duration (P<0.05). At 24 weeks, only the difference in treadmill walk time was maintained. CONCLUSIONS: This study demonstrates that lifestyle changes can improve endothelial function in @entity0 on long-term ADT for @entity1 . The implications for cardiovascular health need further investigation in larger studies over longer duration.

title: Effects of a lifestyle intervention on endothelial function in @entity0 on long-term @entity2 deprivation therapy for XXXX .

answer: @entity1


abstract: BACKGROUND: Treatment of @entity1 with @entity2 deprivation therapy (ADT) is associated with metabolic changes that have been linked to an increase in cardiovascular risk. METHODS: This randomised controlled trial investigated the effects of a 12-week lifestyle intervention that included supervised exercise training and dietary advice on markers of cardiovascular risk in 50 @entity0 on long-term ADT recruited to an on-going study investigating the effects of such a lifestyle intervention on quality of life. @entity0 were randomly allocated to receive the intervention or usual care. Cardiovascular outcomes included endothelial function ( @entity3 ( @entity3 ) of the brachial artery), blood pressure, body composition and serum lipids. Additional outcomes included treadmill walk time and exercise and dietary behaviours. Outcomes were assessed before randomisation (baseline), and 6, 12 and 24 weeks after randomisation. RESULTS: At 12 weeks, the difference in mean relative @entity3 was 2.2% (95% confidence interval (CI) 0.1-4.3, P=0.04) with an effect size of 0.60 (95% CI <0.01-1.18) favouring the intervention group. Improvements in skeletal muscle mass, treadmill walk time and exercise behaviour also occurred in the intervention group over that duration (P<0.05). At 24 weeks, only the difference in treadmill walk time was maintained. CONCLUSIONS: This study demonstrates that lifestyle changes can improve endothelial function in @entity0 on long-term ADT for @entity1 . The implications for cardiovascular health need further investigation in larger studies over longer duration.

title: Effects of a lifestyle intervention on endothelial function in @entity0 on long-term XXXX deprivation therapy for @entity1 .

answer: @entity2


abstract: BACKGROUND: Treatment of @entity1 with @entity2 deprivation therapy (ADT) is associated with metabolic changes that have been linked to an increase in cardiovascular risk. METHODS: This randomised controlled trial investigated the effects of a 12-week lifestyle intervention that included supervised exercise training and dietary advice on markers of cardiovascular risk in 50 @entity0 on long-term ADT recruited to an on-going study investigating the effects of such a lifestyle intervention on quality of life. @entity0 were randomly allocated to receive the intervention or usual care. Cardiovascular outcomes included endothelial function ( @entity3 ( @entity3 ) of the brachial artery), blood pressure, body composition and serum lipids. Additional outcomes included treadmill walk time and exercise and dietary behaviours. Outcomes were assessed before randomisation (baseline), and 6, 12 and 24 weeks after randomisation. RESULTS: At 12 weeks, the difference in mean relative @entity3 was 2.2% (95% confidence interval (CI) 0.1-4.3, P=0.04) with an effect size of 0.60 (95% CI <0.01-1.18) favouring the intervention group. Improvements in skeletal muscle mass, treadmill walk time and exercise behaviour also occurred in the intervention group over that duration (P<0.05). At 24 weeks, only the difference in treadmill walk time was maintained. CONCLUSIONS: This study demonstrates that lifestyle changes can improve endothelial function in @entity0 on long-term ADT for @entity1 . The implications for cardiovascular health need further investigation in larger studies over longer duration.

title: Effects of a lifestyle intervention on endothelial function in XXXX on long-term @entity2 deprivation therapy for @entity1 .

answer: @entity0