abstract: PURPOSE: To determine the genetic and genomic alterations underlying classic @entity6 in Saudi Arabia, a region with social preference for consanguineous marriage. METHODS: Prospective study of consecutive @entity0 referred to a pediatric ophthalmologist in Saudi Arabia (2005-2009). All @entity0 had @entity5 ( @entity5 ) analysis (sequencing and multiplex ligation-dependent probe amplification analysis if sequencing was normal). If @entity5 analysis was negative, the following were performed: candidate gene sequencing ( @entity8 [ @entity8 ], @entity9 [ @entity9 ], @entity7 , subfamily B [ @entity4 ], paired-like homeodomain transcription factor 3 [ @entity11 ], and v-maf avian musculoaponeurotic @entity2 oncogene homolog [MAF]) and molecular karyotyping by array competitive genomic hybridization (250K single nucleotide polymorphism (SNP) arrays). RESULTS: All 12 probands (4 months-25 years of age; four @entity0 and eight @entity0 ) had @entity1 and @entity3 in addition to no grossly visible iris. Four cases were familial. All cases were products of consanguineous unions except for three, one of which was endogamous. Heterozygous @entity5 mutations (including two novel mutations) were detectable in all but two cases, both of which were sporadic. In one of these two cases, the phenotype segregated with homozygosity for a previously-reported pathogenic missense @entity8 variant ( @entity10 ) when homozygosity for chromosome 11q24.2 deletion (chr11:125,001,547-125,215,177 [ @entity12 ; @entity13 ]) was also present. In the other, no genetic or genomic abnormalities were found. CONCLUSIONS: The classic @entity6 phenotype in Saudi Arabia is typically caused by heterozygous @entity5 mutations, even in the setting of enhanced homozygosity from recent shared parental ancestry. For @entity5 -negative cases, interaction between missense variation in an anterior segment developmental gene and copy number variation elsewhere in the genome may be a potential mechanism for the phenotype.

title: Genetic and genomic analysis of classic XXXX in Saudi Arabia.

answer: @entity6


abstract: Since April 2009, a serious @entity2 has been rapidly spread across the world. These @entity2 are caused due to the novel @entity5 origin @entity4 and hence these are commonly called as " @entity5 Flu". This new virus is the reassortment of avian, @entity0 and @entity5 influenza viruses and thus it has a unique genome composition. There are 16 different types of hemagglutinin (HA) and 9 different types of @entity3 (NA) that can be genetically and antigenetically differentiated. The first @entity6 isolated from @entity5 was of the H1N1 subtype and these viruses have been reported to cause @entity2 in @entity5 in many countries. The outbreak of this virus has been transmitted from @entity5 to @entity0 . This new reassorted (exchange of genes) virus which is the cause of 2009 pandemic @entity2 has the ability to spread from @entity0 to @entity0 . This spread of @entity2 should be brought to an end. In this study, a phylogenetic analysis of the nucleotide sequences of the RNA segments of @entity0 H1N1 viruses was carried using MEGA version 4.0 to demonstrate the route map of @entity2 to India. Phylogenetic analysis of the sequences from India, published in Influenza Virus Resource (a database that integrates information gathered from the Influenza Genome Sequencing Project of the @entity1 ( @entity1 ) and the genbank of the (NCBI)) was retrieved and used for the analysis. The results showed that the various segments of the Indian isolates clustered well with the sequences from American, Asian and European countries and thus indicating the transmission of viruses from these places to India.

title: Phylogenetic analysis of H1N1 sequences from pandemic XXXX during 2009 in India.

answer: @entity2


abstract: @entity4 are @entity1 developing as an anomaly of the lymphatic channels. Most of them are discovered in @entity0 and are located mostly in the head and neck with no differences between sexes. Retroperitoneal locations are rare, clinical symptoms not specific and are discovered incidentally. We report the case of a 32-year-old female sex @entity0 with a @entity1 situated in the retroperitoneum, behind the pancreas, discovered by abdominal ultrasound during a diagnostic work-out for @entity3 and @entity2 . Anamnesis, physical examination and CT-scan could not indicate the nature of the cyst. The @entity1 had a shape of a butterfly, crossing the midline in front of the aorta and vena cava. A laparotomy was indicated and established the diagnosis of a @entity5 based on its macroscopic appearance. The @entity1 was approached from its right side by a generous Kocher maneuver and then from the left by disinsertion of the Treitz ligament and elevating the pancreatic body and splenic vessels. It was completely removed. Postoperative course was uneventful. Histopathologic examination confirmed the diagnosis of benign @entity4 . At 2 years of follow-up the @entity0 was free of recidive. CONCLUSIONS: @entity4 are rarely seen in adults. Precise diagnosis is made at laparotomy, imagistic test give details about walls, content, relationship with the surrounding structures and major blood vessels. Complete surgical resection represents the treatment of choice avoiding recurrence.

title: XXXX - considerations upon a case.

answer: @entity4


abstract: @entity12 ( @entity12 ) is carried out as an alternative treatment of @entity10 refractory to conservative measures. An increasingly recognized complication of @entity12 is an @entity11 ( @entity11 ). Neurological manifestations usually dominate the presentation of an @entity11 and result from @entity5 of thrombi, transgressed esophageal contents, or air. AEFs have been reported after @entity12 in 52 @entity0 (23 @entity0 , age 35-76 years), described in 24 publications, so far. AEFs manifest clinically on the average 17 days (3-38 days) after ablation. Neurological manifestations include @entity1 (n = 30), @entity6 (n = 9), transitory-ischaemic attacks (n = 6), @entity7 (n = 6), or @entity2 (n = 5). Imaging studies of the cerebrum most frequently show multiple @entity1 or air @entity8 . The diagnosis is made upon thoracic computed tomography with contrast media. An act of swallowing, trans-esophageal echocardiography, gastroscopy, or esophageal stenting must be avoided not to enlarge the shunt. The only expedient therapy is surgical closure of the @entity4 , but even then, the prognosis is poor with a mortality of 71%. AEFs should be suspected if there is a history of @entity12 followed by fever, @entity3 , postprandial @entity1 , @entity6 , @entity7 , or @entity9 with a latency of days to 5 weeks after ablation. Diagnostic work-up must avoid measures, which enlarge the @entity4 . Treatment is surgical exclusively.

title: Neurological manifestations of XXXX from left atrial ablation.

answer: @entity11


abstract: Recently, it was demonstrated that arteriogenesis is enhanced in @entity0 deficient in regulatory T cells ( @entity3 (+) @entity6 (+) @entity5 (+) T cell), which can suppress effector T cell responses. The present study investigates the effects of these regulatory T cells on arteriogenesis in more detail by either specific expanding or depleting regulatory T cells. Hind limb @entity1 was induced by electro-coagulation of the femoral artery in @entity0 . @entity2 cells were either expanded by injecting @entity0 with a complex of @entity4 with the @entity4 monoclonal antibody JES6-1, or depleted by anti- @entity6 antibody or diphtheria toxin injections in DEREG @entity0 (depletion of regulatory T cells). Blood flow restoration was monitored using laser Doppler perfusion imaging. Collateral arteries were visualized by immunohistochemistry. @entity2 cell expansion led to a moderate though significant suppression of blood flow restoration after @entity1 induction. Surprisingly, depletion of regulatory T cells resulted in minor increase on blood flow recovery. However, collateral and capillary densities in the post- @entity1 skeletal muscle were significantly increased in DEREG @entity0 depleted for regulatory T cells. The presence of regulatory T cells after @entity1 induction when analysed in non-depleted DEREG @entity0 could be demonstrated by green fluorescent protein staining only in lymph nodes in the @entity1 area, and not in the @entity1 muscle tissue. The current study demonstrates that, even under conditions of major changes in regulatory T cell content, the contribution of regulatory T cells to the regulation of the arteriogenic response is only moderate.

title: A limited role for regulatory T cells in post- XXXX neovascularization.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVE: Cardiopulmonary bypass (CPB) in the treatment of locally advanced @entity2 invaded heart or great vessels was not well underwent. The aim of this study is to report the results of these cases with locally advanced @entity2 which were completely resected under CPB in our hospital. METHODS: Four @entity0 with locally advanced @entity2 were operated under CPB. All @entity0 had stage IIIb disease (T4N0M0). Moderate @entity4 CPB was used for all 4 cases. The CPB time was 79 min-155 min and aortic cross-clamp time was 57 min-126 min, respectively. RESULTS: There was no operative death in this series. CPB was smooth, and heart automatically rebeated in the 4 @entity0 . All the 4 @entity0 were discharged in 3 weeks. One @entity0 dead of @entity3 at 13 months after operation, one case dead of distant tumor @entity1 at 22 months after operation. The other two @entity0 have survived over 25 months and 11 months, respectively. CONCLUSIONS: CPB is helpful for completely removal of locally advanced @entity2 .

title: [Experiences of cardiopulmonary bypass in the treatment of locally advanced XXXX ].

answer: @entity2


abstract: OBJECTIVE: To investigate the minimally-invasive ablation of @entity3 of the ethmoid sinuses endonasally. METHODS: A retrospective analysis was done in 19 @entity0 (15 male, 4 female, aged between 14 - 67, medium 37) diagnosed as @entity3 of ethmoid sinuses hospitalized from April 2005 to October 2009. All @entity0 underwent sixteen-detector row computed tomography scan and 3D reconstruction preoperatively. All underwent operation with the help of navigation system and nasal endoscope. RESULTS: The @entity3 in all 19 @entity0 was removed successfully with endoscope and navigation system. Two open procedures (1 through superciliary arch incision and 1 through labiogingival incision) were performed to assist the removal of the @entity1 , 17 @entity1 were removed under endoscopic and navigation guidance. In 5 @entity0 whose @entity3 was localized or with the diameter no more than 2 cm, these @entity3 were removed endonasally with the help of navigation system. The @entity3 in 2 @entity0 was found to have narrow basilar part and relatively dissociative were removed from oral cavity after abscisin the basilar part. The @entity3 in 12 @entity0 were found to have basilar part connected with ante-meso skull base, lamina papyracea, orbital apex, cranialis opticus, fossa orbitalis bone, these @entity3 were removed using electric drill with the guidance of navigation system. All @entity0 were followed up from 8 to 64 months, and were asymptomatic (1 @entity0 who suffered from amblyopia had the symptom disappeared, 2 @entity0 suffered from prosopo-eminence, 1 @entity0 was asymptomatic and 1 @entity0 was feeling better). Two @entity0 underwent removal of crista galli, 1 of them suffered from @entity2 , and recovered after endoscopic repairing procedure and iodoform gauze packing and recovered 15 days later. Two @entity0 who underwent removal of crista galli suffered from anosmia and never recovered after 9 and 26 months follow-up. One @entity0 with @entity3 suffered from repeated crusting and abnormal odor, and recovered after nasal flushing. CONCLUSIONS: Endoscopic ablation of @entity3 of the ethmoid sinuses with the guidance of navigation system is an accurate, secure, minimally-invasive procedure. @entity3 on median line and localized in ethmoid sinus is an indication of this operation. Preoperative CT scan is a safeguard for an accurate operation.

title: [Endoscopic removal of ethmoid XXXX under navigation guidance].

answer: @entity3


abstract: The maximum dosage of @entity5 ( @entity6 ) for treatment of @entity3 ( @entity3 ) formally approved in Japan is 8 mg/week. We intended to examine the efficacy and safety of @entity6 at dosages over 8 mg/week in Japanese @entity3 @entity0 using the large Institute of Rheumatology, @entity3 (IORRA) cohort database. Among 9,122 @entity0 registered in the IORRA database from the October 2000 survey to the October 2007 survey, 5,201 @entity0 who had been treated with @entity6 were selected. We attempted to overcome the drawbacks innate to nonrandomized studies by using longitudinal analyses and multifactorial logistic regression analyses. Cross-sectional analysis of data obtained from the October 2007 survey indicated that dosages of @entity6 higher than 8 mg/week were used in 27.5% of @entity0 treated with @entity6 . Longitudinal analyses based on data from three consecutive phases showed that final Disease Activity Score-28 (DAS28) values were significantly lower [n = 260, mean difference 0.563, 95% confidence interval (CI) 0.438-0.688, P < 2.2   10(-22), two-sided paired t test] than initial values when @entity6 was increased from 8 mg/week or lower to over 8 mg/week. In addition, longitudinal analyses based on data from two consecutive phases indicated decreases in DAS28 values of 0.26    1.04 (n = 690, P = 6.78   10(-11), two-sided paired t test) when @entity6 dosages were increased from 8 mg/week or lower to over 8 mg/week, compared with decreases of 0.07    0.89 (n = 2,125, P = 0.000307) when the dosage was maintained at 8 mg/week. The decreases in DAS28 values were significantly larger in the former than the latter (P = 2.27   10(-6), two-sided unpaired t test). Concerning safety of @entity6 at dosages over 8 mg/week, we performed logistic regression analysis in which the objective variable was the existence or nonexistence of self-reported side-effects and the explanatory variable was the @entity6 dosage in the former phase, with adjustments made for age, sex, body mass index (BMI), @entity2 administration, @entity7 administration, concomitant @entity4 , and @entity1 . The results indicated that @entity6 dosages over 8 mg/week did not have any association with either severe or severe + moderate side-effects. These data regarding both efficacy and safety of @entity6 at dosages over 8 mg/week in Japanese @entity3 @entity0 would provide the basis for use of the drug at dosages currently not formally approved by the Japanese government.

title: Studies of the efficacy and safety of XXXX at dosages over 8 mg/week using the IORRA cohort database.

answer: @entity5


abstract: PURPOSE: Previous studies show that @entity4 pectin nasal spray (FPNS) rapidly provides clinically meaningful @entity2 relief in the treatment of breakthrough @entity1 (BTCP). This study assessed the long-term tolerability, acceptability and consistency of effect of FPNS in @entity0 with BTCP. METHODS: @entity0 (new and rolled over from earlier controlled studies) with @entity1 experiencing one to four episodes per day of BTCP whilst taking >=  60 mg/day of @entity3 (or equivalent) given orally for @entity1 entered an open-label 16-week safety study. Safety and tolerability were assessed by adverse events (AEs), adverse drug reactions (ADRs), withdrawal due to AEs and by nasal assessments. Acceptability assessments included ratings of overall satisfaction with each treated episode and ease of use and convenience of FPNS. Additional rescue medication and dose stability were used to evaluate the consistency of effect. RESULTS: Four hundred three @entity0 were included in the safety and intent-to-treat analysis (42,227 episodes), 356 entered the treatment phase and 110 completed 16 weeks. Overall, 24.6% of 403 @entity0 reported treatment-related treatment-emergent AEs that were generally mild/moderate and typical of opioids; 20 @entity0 discontinued treatment due to an AE (9 were ADRs). Nasal assessments revealed no clinically significant effects; 94% of FPNS-treated episodes required no additional rescue medication. More than 90% of @entity0 did not have to increase their dose during the study. @entity0 reported overall satisfaction with FPNS for 90.1% of episodes. At week 12, 96.9% of @entity0 were satisfied with the ease of use and 97.9% with the convenience of FPNS. CONCLUSIONS: FPNS was generally well tolerated and well accepted for the treatment of BTCP, and doses remained stable over the 4-month study period.

title: Long-term tolerability, efficacy and acceptability of @entity4 pectin nasal spray for breakthrough XXXX .

answer: @entity1


abstract: PURPOSE: Previous studies show that @entity4 pectin nasal spray (FPNS) rapidly provides clinically meaningful @entity2 relief in the treatment of breakthrough @entity1 (BTCP). This study assessed the long-term tolerability, acceptability and consistency of effect of FPNS in @entity0 with BTCP. METHODS: @entity0 (new and rolled over from earlier controlled studies) with @entity1 experiencing one to four episodes per day of BTCP whilst taking >=  60 mg/day of @entity3 (or equivalent) given orally for @entity1 entered an open-label 16-week safety study. Safety and tolerability were assessed by adverse events (AEs), adverse drug reactions (ADRs), withdrawal due to AEs and by nasal assessments. Acceptability assessments included ratings of overall satisfaction with each treated episode and ease of use and convenience of FPNS. Additional rescue medication and dose stability were used to evaluate the consistency of effect. RESULTS: Four hundred three @entity0 were included in the safety and intent-to-treat analysis (42,227 episodes), 356 entered the treatment phase and 110 completed 16 weeks. Overall, 24.6% of 403 @entity0 reported treatment-related treatment-emergent AEs that were generally mild/moderate and typical of opioids; 20 @entity0 discontinued treatment due to an AE (9 were ADRs). Nasal assessments revealed no clinically significant effects; 94% of FPNS-treated episodes required no additional rescue medication. More than 90% of @entity0 did not have to increase their dose during the study. @entity0 reported overall satisfaction with FPNS for 90.1% of episodes. At week 12, 96.9% of @entity0 were satisfied with the ease of use and 97.9% with the convenience of FPNS. CONCLUSIONS: FPNS was generally well tolerated and well accepted for the treatment of BTCP, and doses remained stable over the 4-month study period.

title: Long-term tolerability, efficacy and acceptability of XXXX pectin nasal spray for breakthrough @entity1 .

answer: @entity4


abstract: Changes in the cellularity of various adipose tissues in growing @entity0 were analyzed. Fifty male @entity0 were slaughtered between 15 and 65% of mature weight. The whole adipose mass, separated by dissection, was divided into three parts: subcutaneous, intermuscular, and internal adipose tissues. Lipid content, cell size and distribution, as well as cell number of these three parts were determined. Adipose cells became 15 times greater from 15 to 65% mature weight, whereas total adipose cell number increased only 1.8-fold. However, a significant @entity2 occurred near 45% mature weight. These results suggested a cell size regulation by @entity2 . Over the whole period studied (15-65% mature weight), @entity2 was far higher in subcutaneous adipose tissue than in other tissues. This is discussed as related to the higher relative growth of this tissue. In each fatty tissue, two identical development periods were observed. Each of them began by an increase in small-sized cells ( @entity2 ) followed by the filling of these cells ( @entity1 ). These two periods were particularly clear in the case of subcutaneous tissue, in which the second @entity2 occurred slightly later than in other fatty tissues. So, in all respects, subcutaneous fatty tissue appears to develop later than other tissues studied.

title: Cellularity of XXXX adipose tissues: developmental changes from 15 to 65 percent mature weight.

answer: @entity0


abstract: @entity6 belongs to the non-tuberculous or "atypical" mycobacteria. The reservoirs for these ubiquitous and slowly growing bacteria are both fresh water and salt water. In particular, aquaria should be considered as important source of hobby-related @entity1 especially of fingers, hands and forearms. Affected are both immunosuppressed @entity0 and @entity0 with an intact immune system. Distinctive are erythematous plaques and nodules with tendency for @entity5 , crusting, and superficial ulcerations, sometimes as @entity1 . The histology shows non-caseation granulomas containing epithelioid cells and Langhans giant cells. Using the Ziehl Neelsen staining, typical acid-fast rods are not always detectable. The molecular biological detection of mycobacterial DNA using polymerase chain reaction represents the standard method of diagnosis. Cryotherapy is frequently used as first treatment. For the often long-term tuberculostatic therapy, @entity2 , @entity3 , and @entity4 are the most used agents.

title: [Infections due to XXXX : a review].

answer: @entity6


abstract: Symptoms management in @entity2 is an integral part of its care. Accurate assessment and addressing the different symptoms provides increased quality of life among @entity0 with @entity2 . @entity16 may be identified as primary, secondary, or tertiary symptoms. Primary symptoms, such as @entity10 , @entity17 , are directly related to @entity3 and @entity7 . Secondary symptoms, such as @entity5 as a result of urinary retention, are a result of the primary symptoms. Tertiary symptoms, such as @entity6 or social isolation, are a result of the social and psychological consequences of the disease. Common @entity16 include @entity14 and @entity10 ; decreased balance, @entity11 and gait problems; @entity6 and cognitive issues; bladder, bowel, and @entity4 ; and @entity1 . Less-common symptoms include @entity15 and @entity13 , vertigo, and @entity8 . Rare symptoms in @entity2 include @entity9 , @entity7 , and @entity12 . Symptom management includes nonpharmacological methods, such as rehabilitation and psychosocial support, and pharmacological methods, ie, medications and surgical procedures. The keys to symptom management are awareness, knowledge, and coordination of care. Symptoms have to be recognized and management needs to be individualized. @entity2 therapeutics include nonpharmacological strategies that consist of lifestyle modifications, rehabilitation, social support, counseling, and pharmacological agents or surgical procedures. The goal is vigilant management to improve quality of life and promote realistic expectations and hope.

title: Therapeutics for XXXX .

answer: @entity16


abstract: BACKGROUND: To present our experience with Laparo-Endoscopic Single Site (LESS) management of @entity1 . MATERIAL AND METHOD: Between September 2008 and November 2009, 18 @entity0 underwent single port transumbilical laparoscopic surgery for nephrectomy for a nonfunctioning kidney (7 cases), cyst decortications for symptomatic @entity1 (10 cases), and redo-dismembered pyeloplasty with previously failed laparoscopic surgical repair (1 case). @entity0 underwent surgery through a single 2-cm infraumbilical incision with the triport laparoscopic-port. All pathological reports of LESS nephrectomy and cyst decortications confirmed with chronic @entity5 and simple cysts, respectively Histology of xanthogranulomotus @entity5 showed two cases of the nephrectomy procedure. RESULTS: Mean @entity0 age and BMI were 61 +/- SD 14.2 years and 24.75 +/- SD 11.2 kg/m2, respectively Mean operating time was 187.7 +/- SD 71.4 min. LESS was a possible and safe approach in 77.8% of @entity0 . All LESS cyst decortications and redo-pyeloplasty were completed without major complications or conversion to open surgery. However, there was one case each of LESS cyst decortication and pyeloplasty requiring an additional 3-mm port for suturing due to @entity3 and an instrument error. For LESS nephrectomy, two (28.6%) with higher waist circumference were converted to standard laparoscopic nephrectomy due to failure to progress. One post operative complication of incisional @entity2 occurred in a @entity0 with chronic @entity6 and @entity4 . CONCLUSION: LESS for the management of @entity1 is an effective and safe treatment option with selected @entity0 and experienced surgeon.

title: Laparo-endoscopic single site (LESS) management of XXXX : evaluation of complications.

answer: @entity1


abstract: BACKGROUND: Tightening and contracture of the joint capsule are hallmarks of @entity3 of the shoulder (ACS). However, quantification of capsular stiffness and its relation to clinical features have not been investigated thoroughly. OBJECTIVES: To quantify capsular stiffness during @entity4 ( @entity4 ) and to investigate its relationships with @entity2 severity, symptom duration, range of motion (ROM), gender, and @entity1 status. DESIGN: Case series. SETTING: University outpatient clinic of physical medicine and rehabilitation. @entity0 : A total of 107 consecutive @entity0 with ACS who underwent @entity4 . METHODS: Pressure-volume monitoring data during @entity4 , @entity2 severity, symptom duration, shoulder ROM, and @entity1 status were obtained by retrospective chart review. Capsular stiffness ( @entity5 ) was measured by calculating the slope of the elastic phase in pressure-volume curves. ROM was evaluated in 3 directions (flexion, abduction, and external rotation) with a goniometer, and the sum of the 3 ROMs was calculated. MAIN OUTCOME MEASUREMENTS: Pearson correlation coefficients and comparisons of averages were used to analyze the relationships between @entity5 and clinical features. RESULTS: The mean @entity5 of the total group of @entity0 was 26.0    14.2 mmHg/mL. Shoulder @entity2 in motion or rest did not correlate with @entity5 . @entity0 with stiffer capsules had smaller sums of ROMs (r = -.298, P = .002), with distinct limitations in external rotation and abduction (r = -.278, P = .004 and r = -.313, P = .001, respectively). @entity0 had significantly stiffer capsules than @entity0 (29.5    14.3 versus 20.2    12.1 mmHg/mL, P = .001). @entity1 status had no significant effect on capsular stiffness. CONCLUSIONS: Capsular stiffness of the glenohumeral joint significantly correlated with limitation in shoulder ROM, especially in the abduction and external rotation directions, whereas there were no meaningful relationships with @entity2 during motion or rest. This is the first study to reveal the relationships between in  vivo quantified capsular stiffness and shoulder ROM limitations.

title: Relationships Between Capsular Stiffness and Clinical Features in XXXX of the Shoulder.

answer: @entity3


abstract: INTRODUCTION: Up to 50% of adults with @entity3 ( @entity3 ) and left @entity1 demonstrate Cheyne-Stokes respiration (CSR), although the mechanisms remain controversial. Because CSR has been minimally studied in @entity0 , we sought to assess the prevalence of CSR in @entity0 with low and high output @entity3 . We hypothesized that the existence of CSR only in @entity0 with low output @entity3 would support the importance of circulatory delay as a CSR mechanism. METHODS: Thirty @entity0 participated: 10 @entity0 with @entity3 , 10 matched @entity0 with no @entity2 , and 10 adults with @entity3 . All @entity0 underwent an in-laboratory polysomnographic sleep study. RESULTS: @entity3 @entity0 's average age (  SEM) was 3.6        2.1 years vs. 3.7        2 years in the age-matched control group. The average ejection fraction of three @entity0 with low output @entity3 was 22        6.8%. The remaining seven had normal-high cardiac output. Compared to control @entity0 , @entity3 @entity0 were tachypneic and tachycardic during stable sleep (55.1        6.7 vs. 26.9        3 breath/min and 127.6        8.7 vs. 97.6        6.9 beats/min, respectively, p   <   0.05 for both). They had shorter total sleep time (195        49 vs. 373        16 min, p   <   0.05) with a low sleep efficiency of 65.6        6%. None of the @entity0 had a pattern of CSR at any time during the studies while the adults with @entity3 had 40% prevalence of CSR. CONCLUSIONS: The complete absence of CSR in our sample of @entity0 with @entity3 compared to the 40% prevalence in the adults with @entity3 we studied, suggests that CSR may be an age-dependent phenomenon. Thus, we speculate that regardless of the exact mechanism which drives CSR, age is an over-riding factor.

title: The occurrence of cheyne-stokes respiration in XXXX : the effect of age.

answer: @entity3


abstract: @entity7 in myocardium may lead to the @entity3 , which may progress to @entity4 and @entity6 . @entity5 has been reported to cause @entity8 and other @entity2 especially in immunocompromised @entity0 . To understand the cellular responses during the establishment of @entity2 in myocardium, we challenged differentiated H9C2 cells with @entity9 . We also did comparison studies with infected undifferentiated form of H9C2 cells. Invasion studies revealed that @entity9 can invade both forms of cells and is able to survive and replicate within the host. Internalization of @entity9 was confirmed by live cell imaging and flow cytometry analysis. Though invasion of the pathogen triggered an increased ROS production in the host cells at earlier post- @entity2 periods, it was decreased at later post- @entity2 periods. Invasion of @entity9 induced cell @entity1 through apoptosis in differentiated H9C2 cells. Significant decrease in cell size, formation of polarized mitochondria, and nuclear fragmentation were observed in the infected differentiated cells. On the contrary, cell @entity1 preceded by multinucleation was observed in infected undifferentiated H9C2 cells. Morphological markers such as multinuclei and micro nuclei were observed. Cell cycle arrest in G2/M phase corroborates that the undifferentiated H9C2 cells experienced cell @entity1 preceded by multinucleation.

title: @entity9 induces distinct cell XXXX mechanisms in H9C2 cells and its differentiated form.

answer: @entity1


abstract: @entity7 in myocardium may lead to the @entity3 , which may progress to @entity4 and @entity6 . @entity5 has been reported to cause @entity8 and other @entity2 especially in immunocompromised @entity0 . To understand the cellular responses during the establishment of @entity2 in myocardium, we challenged differentiated H9C2 cells with @entity9 . We also did comparison studies with infected undifferentiated form of H9C2 cells. Invasion studies revealed that @entity9 can invade both forms of cells and is able to survive and replicate within the host. Internalization of @entity9 was confirmed by live cell imaging and flow cytometry analysis. Though invasion of the pathogen triggered an increased ROS production in the host cells at earlier post- @entity2 periods, it was decreased at later post- @entity2 periods. Invasion of @entity9 induced cell @entity1 through apoptosis in differentiated H9C2 cells. Significant decrease in cell size, formation of polarized mitochondria, and nuclear fragmentation were observed in the infected differentiated cells. On the contrary, cell @entity1 preceded by multinucleation was observed in infected undifferentiated H9C2 cells. Morphological markers such as multinuclei and micro nuclei were observed. Cell cycle arrest in G2/M phase corroborates that the undifferentiated H9C2 cells experienced cell @entity1 preceded by multinucleation.

title: XXXX induces distinct cell @entity1 mechanisms in H9C2 cells and its differentiated form.

answer: @entity9


abstract: PURPOSE: Currently, there are several @entity6 combination regimens for first-line therapy of metastatic @entity1 (mCRC). In this study, we compared the survival outcomes of mCRC @entity0 treated with bevacizumab in combination with either modified @entity7 /FA/ @entity6 (mFOL- FOX6) or @entity4 / @entity6 (XELOX). METHODS: We designed a two-arm retrospective study of mCRC @entity0 with @entity5 who were treated with bevacizumab and either mFOLFOX6 or XELOX and who had complete clinical and treatment data. We analysed their therapeutic responses, adverse events, progression-free survival (PFS), and overall survival (OS), and then determined whether there were any statistically significant differences. RESULTS: A total of 131 @entity0 (85 male; 65% and 46 female; 35%) were evaluated. Fifty-seven @entity0 (43.5%) were treated with bevacizumab and mFOLFOX6 and 74 (56.5%) with bevacizumab and XELOX. The median PFS was 9.1 months (95% CI, 4.9-13.1) and 10 months (95% CI, 4.2-15.9) in the mFOLFOX6 and XELOX arms, respectively (p=0.610). The median OS was 29 months (95% CI, 21.6- 34.3) and 27.5 months (95% CI 20-38) in the mFOLFOX6 and XELOX arms (p=0.812), respectively. The most common reason for treatment withdrawal was disease progression (102 @entity0 ; 91%) and the most common grade 3-4 @entity3 was @entity2 ( <=14%). CONCLUSION: Our results show that XELOX is a safe and effective alternative to mFOLFOX6 when combined with bevacizumab as first-line treatment for mCRC @entity0 .

title: Comparison of first-line bevacizumab in combination with mFOLFOX6 or XELOX in metastatic XXXX .

answer: @entity1


abstract: PURPOSE: To assess the efficacy and safety of using 3D conformal radiation therapy (3DCRT) to treat @entity2 ( @entity2 ) in a Caucasian cohort and evaluate factors with prognostic value. METHODS: Between September 2001 and November 2012, 44 @entity2 @entity0 with a mean age of 57 years underwent 3DCRT at the University Hospital of Ioannina. Nineteen @entity0 (43%) presented with WHO type 1 and 2 histology. Thirty two @entity0 (73%) had @entity2 (stage III/IV). Thirty-one @entity0 (70%) received chemotherapy. The mean total radiotherapy dose prescribed to the planning target volume ( @entity4 ) was 67.2 Gy. The daily dose was 1.8 Gy. RESULTS: With a median follow up of 43 months (range 8.4-125), the 4-year local relapse-free (LRFS), nodal relapse-free (NRFS), distant metastases-free survival (DMFS), disease-free survival (DFS) and overall survival (OS) were 90, 87, 91, 80 and 82%, respectively. Histology was a significant prognostic factor concerning overall survival, with worst prognosis in @entity0 with WHO type 1/2 compared to type 3. Age <70 years, absence of retropharyngeal lymph node @entity1 , complete response after treatment and the completion of >= 4 cycles of concurrent weekly @entity6 favored overall survival. Fifteen @entity0 (34%) developed grade 3 late side effects ( @entity7 : 6, soft tissue @entity3 : 6, @entity5 : 2, @entity8 : 1). CONCLUSION: 3DCRT in our Caucasian cohort, characterized by predominantly @entity2 , combined with chemotherapy, is an effective treatment modality approach in @entity0 with @entity2 with excellent tolerance.

title: 3D conformal radiotherapy in primary XXXX : effectiveness and prognostic factors.

answer: @entity2


abstract: BACKGROUND: Various studies showed that chemotherapy can control @entity2 morbidity, but association of measures (water supply, sewage disposal and increase of socioeconomic conditions) is necessary for transmission control. METHODOLOGY/PRINCIPAL FINDINGS: A survey dealing with socioeconomic conditions, snail survey, contact with natural waters, and clinical and stool examinations was undertaken at an endemic area in the State of Minas Gerais, Brazil. The methodology used was the same for both evaluations (1981 and 2005). Four hundred and seventy-five out of 1,474 individuals studied in 1981 could be contacted. From these, 358 were submitted to stool examination, and 231 of them were clinically examined. @entity0 eliminating @entity1 eggs in their stools were treated. The results showed that the prevalence rate in Comercinho, a municipality of the State of Minas Gerais, Brazil, was substantially reduced to 70.4% and 1.7% in 1981 and 2005, respectively, as well as the frequency of the hepatosplenic form (7% to 1.3%) after five treatments effectuated between 1981 and 1992. No other new case of this form was detected from 1981 onwards. Another important aspect to be considered was the improvement of @entity0 's living standard that occurred in the region after more than two decades' efforts (better housing, professional skill and adequate basic sanitation). CONCLUSION/SIGNIFICANCE: The control of morbidity and very significant decrease of @entity2 transmission in an area until then considered as hyperendemic was possible by means of association of successive specific treatments of the local population, together with the construction of privies, water supply in the houses and improvement of socioeconomic conditions.

title: Evaluation of a 25-year-program for the control of XXXX mansoni in an endemic area in Brazil.

answer: @entity2


abstract: PURPOSE: To evaluate the effectiveness of reconstruction with a modular hemipelvic endoprosthesis after @entity4 resection. METHODS: We retrospectively studied 50 consecutive @entity0 diagnosed with @entity4 from 2003 to 2013. All @entity0 received limb-salvage surgery and reconstruction with modular hemipelvic endoprosthesis. RESULTS: @entity0 were followed for an average of 54 months. At the most recent follow-up, 32 @entity0 were alive with an estimated three-year and five-year survival rate of 66.3% and 57.5% according to the Kaplan-Meier survival analysis. Eighteen @entity0 died from the @entity2 , with a mean survival of 28 months, and 9 @entity0 experienced local recurrence at an average of 19.6 months after surgery. @entity0 with marginal or intracapsular surgical margins had a significantly higher recurrence rate than those with wide margins (p=0.02). @entity1 occurred in 12 cases at an average of 16 months after surgery. The perioperative complication rate was 48.0%, and the most common complications were wound healing disturbance (28.0%) and deep @entity3 (14.0%). The endoprosthetic complication rate was 16.0%, and breakage of the pubic connection plate was the most common complication. The mean Musculoskeletal Tumor Society score was 61.4%. CONCLUSION: Reconstruction with a modular hemipelvic endoprosthesis after @entity4 resection can improve function, with an acceptable complication rate.

title: Reconstruction with modular hemipelvic endoprosthesis after XXXX resection: a report of 50 consecutive cases.

answer: @entity4


abstract: UNASSIGNED: This study was conducted at high altitude (2100  m above sea level). A total of 208 d-old male broilers (Ross 308) were randomised across 16 floor pens and reared up to 42 d. A normal-protein diet (NPD) was formulated according to the National Research Council. A @entity1 ( @entity1 ) was prepared with dietary protein reduced by 30  g/kg relative to that of the NPD. Two additional diets were prepared by adding 2 and 4  g  @entity5 ( @entity3 )/kg to the @entity1 . At the end of trial (42 d), blood sampling was done and carcass characteristics were recorded. @entity3 supplementation of the @entity1 at 4  g improved feed:gain in the growing stage and throughout the trial compared with the @entity1 . The right-to-total ventricular weight ratio was significantly increased in birds fed on @entity1 compared with those fed on NPD or @entity3 -supplemented @entity1 . Feeding @entity1 caused a significant decrease in plasma concentrations of @entity4 (NO) and @entity2 . Plasma NO level, however, was restored by @entity3 supplementation of @entity1 . @entity3 supplementation of @entity1 , however, significantly reduced the rate of @entity0 syndrome mortality compared to the negative control fed on @entity1 .

title: XXXX supplementation of reduced-protein diets improves pulmonary hypertensive response in broiler chickens reared at high altitude.

answer: @entity5


abstract: UNASSIGNED: An expanded G4C2 repeat in @entity3 represents the most common known genetic cause of @entity1 ( @entity1 ) and @entity2 ( @entity2 ). However, the lower limit for pathological expansions is unknown (the suggested cutoff is 30 repeats). It has been proposed that the expansion might have occurred only once in @entity0 history and subsequently spread throughout the population. However, our present findings support a hypothesis of multiple origins for the expansion. We report a British-Canadian family in whom a    70-repeat allele from the father (unaffected by @entity1 or @entity2 at age 89 years) expanded during parent-offspring transmission and started the first generation affected by @entity1 (four @entity0 carry an    1,750-repeat allele). Epigenetic and RNA-expression analyses further discriminated the offspring's large expansions (which were methylated and associated with reduced @entity3 expression) from the    70-repeat allele (which was unmethylated and associated with upregulation of @entity3 ). Moreover, RNA foci were only detected in fibroblasts from offspring with large expansions, but not in the father, who has the    70-repeat allele. All family members with expansions were found to have an ancient known risk haplotype, although it was inherited on a unique 5-Mb genetic backbone. We conclude that small expansions (e.g., 70 repeats) might be considered "pre-mutations" to reflect their propensity to expand in the next generation. Follow-up studies might help explain the high frequency of @entity1 - or @entity2 -affected individuals with an expansion but without a familial history (e.g., 21% among Finnish @entity1 subjects).

title: Jump from Pre-mutation to Pathologic Expansion in XXXX .

answer: @entity3


abstract: Tipula iridescent virus (TIV) is a relatively large particle containing about 15% DNA. As shown elsewhere by X-ray microanalysis (Thomas RS, Corlett M: J Histochem Cytochem 29:394, 1981), low-temperature @entity0 plasma microincineration of the virus produces a stable @entity3 ash representing this DNA nearly quantitatively. @entity2 ( @entity2 ) of entire particles after plasma incineration shows the ash confined to the viral cores, confirming the previously known general location of the nucleic acid. Examination of ultrathin-sectioned virus crystals after plasma etching or ashing shows, on a still finer scale, that the DNA is probably confined to a shell structure within the core. A fine trace of ash from the capsid, seen in some preparations, may represent a phospholipid internal membrane known to be present. The possibilities of ash pattern artifacts are discussed. Heating experiments show that the ash patterns (and native virus particles) evaporate completely at high temperature, consistent with their presumed @entity4 composition. A heat-stable ash could be formed, however, when the viral DNA became accidentally stained with @entity1 from the steel @entity2 grids used--a noteworthy artifact. The present work suggests some future possibilities of the plasma microincineration technique. In particular, the ability to see directly the fine distribution of mineral concentrations in ash patterns with the full resolution of @entity2 should be a powerful adjunct to increase effectively the sensitivity and resolution of X-ray microanalysis of mineral constituents in biological specimens.

title: Localization of DNA phosphorus in Tipula iridescent virus by XXXX plasma microincineration. I. Electron microscopy of ash structures.

answer: @entity0


abstract: BACKGROUND: @entity2 is a near-cosmopolitan zoonosis caused by adult or larval stages of tapeworms (cestodes) into the genus Echinococcus (family Taeniidae). It was demonstrated that platelets were capable of killing parasites independent from leukocytes. PURPOSE: The aim of our study was to examine mean platelet volume ( @entity1 ), platelet mass (PM) and platelet count (PC), which are practical indicators of platelet activity in preoperative and postoperative periods of the @entity0 with hydatid cyst. METHODS: In this retrospective study we evaluated 72 @entity0 admitted to clinic of chest surgery with a diagnosis of pulmonary hydatid cyst in our hospital between January, 2006, and October, 2008. The @entity1 , PC, and PM were evaluated by complete blood count. PM was calculated by multiplying @entity1 and PLT. RESULTS: PREOPERATIVE @entity1 VALUES OF THE @entity0 WAS FOUND TO BE SIGNIFICANTLY HIGHER THAN POSTOPERATIVE @entity1 VALUES (MEAN: 8.07  0.83, 7.78  0.87, p= 0.002). Preoperative PM values (median: 2456.75, range: 1013.70-5046.60) was found to be higher when compared to postoperative PM values (median: 2280.80, range: 134.20-4042.60) (p= 0.039). PC values were not significantly different between two periods (Preoperative-postoperative PC mean values: 320.48  98.42, 307.29  96.45, p= 0.286). CONCLUSION: In this study, we demonstrated that there were no statistical difference in PC for both periods but, @entity1 and PM were found statistical higher than postoperative period in preoperative period. PM and PM can be used as markers of disease activity in @entity0 who undergo surgical resection of hydatid cyst.

title: Evaluation of platelet parameters in XXXX with pulmonary hydatid cyst.

answer: @entity0


abstract: The long term follow up studies on cases of @entity1 during pregnancy or delivery were reviewed in 181 @entity0 administrated in our clinic. The results as follows: 1. An incidence of @entity0 with @entity1 during pregnancy was 1.46 per cent as a whole, and there was increasing tendency in @entity2 . 2. An @entity3 during pregnancy was seen in 7.7 per cent and all cases with NYHA III grade had an incidence of 100 per cent. 3. The occurrence of @entity7 and @entity8 pregnancy were more frequently seen in group of @entity2 than in controls. But, no difference was observed in spontaneous @entity5 . 4. 28 @entity0 with Starr-Edwards prosthetic heart valves became pregnant in our clinic. In these pregnancies, 5 cases receiving with @entity4 therapy resulted in 3 anomalies of new born and in 2 spontaneous @entity6 . So, the use of @entity4 seemed to have the risk to the fetus. But omission of the anticoagulant therapy on the other hand, increased the danger of systemic embolization to the mother. 5. The follow up study by mail in some cases revealed that, as a general, pregnancy and delivery may aggravate the condition of @entity0 , especially who had mitral @entity3 .

title: [Clinical studies on cases of XXXX during pregnancy (author's transl)].

answer: @entity1


abstract: The histogenesis of @entity2 can not be sufficiently accounted for by a single theory. Thus it may be necessary to pressure plural theories for the explanation of their histogenesis. On collected 253 cases of @entity1 , some clinical and pathological studies were carried out and classified to @entity3 (A) 37%, @entity0 ( @entity0 ) 17%, and others (A+ @entity0 ) 45%. Age of the group @entity0 @entity3 (A) 37%, @entity0 ( @entity0 ) 17%, and others (A+ @entity0 ) 45%. Age of the group @entity0 tended to be younger, as compared with other groups. Pathological study revealed that in group (A+ @entity0 ), the lesion tended to be younger, as compared with other groups. Pathological study revealed that in group (A+ @entity0 ), the lesion in uterine wall was extensive and deep proliferation in many cases, and it was frequently more at least than group A. Especially, it is necessary to distinguish from each other two different cases which showed @entity0 , that is, to distinguish them by the presence or absence of @entity3 . In the case of group @entity0 complicated by A, it is thought highly probable that discrete dissemination may take place from the foci of @entity3 . In the case of group @entity0 there may be sufficient room for the application of the Sampson's theory or metaplastic theories. In view of conspicuous trait in the age, however, the possibility of lymphogenous dissemination of @entity1 may be valuable.

title: Study on histogenesis of XXXX .

answer: @entity2


abstract: @entity0 with @entity4 ( @entity4 ) often present with symptoms similar to those of @entity2 ( @entity2 ). We analyzed blood concentrations of mediators of @entity1 and platelet- and monocyte-activity markers in @entity0 with @entity4 and @entity2 for significant differences. Clinical data of @entity0 with @entity4 (n = 16) and acute @entity2 (n = 16) were obtained. Serial blood samples were taken at the time of hospital admission (t(0)), after 2-4 days (t(1)) and after 4-7 weeks (t(2)), respectively. Plasma concentrations of @entity3 , @entity7 , soluble @entity6 ligand (sCD40L), and @entity5 ( @entity5 ) were determined with an ELISA. Tissue factor binding on monocytes, platelet-activation marker @entity8 , platelet @entity9 ( @entity9 ), and platelet-monocyte aggregates were measured using flow cytometry. Expression of @entity8 on platelets and @entity3 plasma levels were significantly lower in @entity0 with @entity4 compared to @entity2 at the time of hospital admission. @entity7 plasma levels were significantly elevated in @entity0 with @entity4 compared to @entity0 with @entity2 at 2-4 days after hospital admission. No significant differences were observed concerning sCD40L and @entity5 plasma levels, tissue factor binding on monocytes, @entity9 expression on platelets, and platelet-monocyte aggregates at any point in time. Our results indicate that inflammatory mediators and platelet-activity markers contribute to the differences in the pathogenesis of @entity2 and @entity4 .

title: Platelet and monocyte activity markers and mediators of @entity1 in XXXX .

answer: @entity4


abstract: @entity0 with @entity4 ( @entity4 ) often present with symptoms similar to those of @entity2 ( @entity2 ). We analyzed blood concentrations of mediators of @entity1 and platelet- and monocyte-activity markers in @entity0 with @entity4 and @entity2 for significant differences. Clinical data of @entity0 with @entity4 (n = 16) and acute @entity2 (n = 16) were obtained. Serial blood samples were taken at the time of hospital admission (t(0)), after 2-4 days (t(1)) and after 4-7 weeks (t(2)), respectively. Plasma concentrations of @entity3 , @entity7 , soluble @entity6 ligand (sCD40L), and @entity5 ( @entity5 ) were determined with an ELISA. Tissue factor binding on monocytes, platelet-activation marker @entity8 , platelet @entity9 ( @entity9 ), and platelet-monocyte aggregates were measured using flow cytometry. Expression of @entity8 on platelets and @entity3 plasma levels were significantly lower in @entity0 with @entity4 compared to @entity2 at the time of hospital admission. @entity7 plasma levels were significantly elevated in @entity0 with @entity4 compared to @entity0 with @entity2 at 2-4 days after hospital admission. No significant differences were observed concerning sCD40L and @entity5 plasma levels, tissue factor binding on monocytes, @entity9 expression on platelets, and platelet-monocyte aggregates at any point in time. Our results indicate that inflammatory mediators and platelet-activity markers contribute to the differences in the pathogenesis of @entity2 and @entity4 .

title: Platelet and monocyte activity markers and mediators of XXXX in @entity4 .

answer: @entity1


abstract: @entity7 ( @entity7 ) is a progressive @entity2 caused by @entity7 . First choice of treatment in @entity7 @entity0 is @entity1 ( @entity1 ). The effect of @entity1 has been shown to have limited influence on skeletal manifestations by poor penetration of musculoskeletal tissues by the enzyme derived from donor leucocytes. Aim of this study was to investigate the effect of @entity1 on the craniocervical junction (CCJ) in @entity7 @entity0 . We analysed retrospectively sequential magnetic resonance imaging (MRI) scans of 30 @entity0 with @entity7 treated by @entity1 since 1982 at the Royal Manchester @entity0 's Hospital, UK, in order to determine whether the @entity0 suffer from @entity8 . Results were compared with biochemical and clinical characteristics: Enzyme activity (EA), chimerism, urinary glycosaminoglycan (GAG) excretion and neurological status. Investigations were part of standard clinical procedures. Results are descriptive in presentation. In 26/30 @entity0 a @entity3 was feasible. The majority showed a normal dens length and an increase with age. Only 3/26 revealed a @entity8 . One of them had only partial donor engraftment (DE) with reduced EA, one of them suffered from @entity5 ( @entity5 ). One @entity0 with only partial DE and reduced EA presented with @entity4 until preadolescence but normalized later on. There may be a trend towards lower EA and the occurrence of DH in transplanted @entity6 @entity0 - perhaps the dosage of enzyme plays a role in the correction of skeletal complications in this @entity0 group. @entity1 @entity0 with incomplete DE and therefore lower EAs may require special attention and care.

title: The craniocervical junction following successful XXXX for @entity7 ( @entity7 ).

answer: @entity1


abstract: @entity7 ( @entity7 ) is a progressive @entity2 caused by @entity7 . First choice of treatment in @entity7 @entity0 is @entity1 ( @entity1 ). The effect of @entity1 has been shown to have limited influence on skeletal manifestations by poor penetration of musculoskeletal tissues by the enzyme derived from donor leucocytes. Aim of this study was to investigate the effect of @entity1 on the craniocervical junction (CCJ) in @entity7 @entity0 . We analysed retrospectively sequential magnetic resonance imaging (MRI) scans of 30 @entity0 with @entity7 treated by @entity1 since 1982 at the Royal Manchester @entity0 's Hospital, UK, in order to determine whether the @entity0 suffer from @entity8 . Results were compared with biochemical and clinical characteristics: Enzyme activity (EA), chimerism, urinary glycosaminoglycan (GAG) excretion and neurological status. Investigations were part of standard clinical procedures. Results are descriptive in presentation. In 26/30 @entity0 a @entity3 was feasible. The majority showed a normal dens length and an increase with age. Only 3/26 revealed a @entity8 . One of them had only partial donor engraftment (DE) with reduced EA, one of them suffered from @entity5 ( @entity5 ). One @entity0 with only partial DE and reduced EA presented with @entity4 until preadolescence but normalized later on. There may be a trend towards lower EA and the occurrence of DH in transplanted @entity6 @entity0 - perhaps the dosage of enzyme plays a role in the correction of skeletal complications in this @entity0 group. @entity1 @entity0 with incomplete DE and therefore lower EAs may require special attention and care.

title: The craniocervical junction following successful @entity1 for XXXX ( @entity7 ).

answer: @entity7


abstract: @entity7 ( @entity7 ) is a progressive @entity2 caused by @entity7 . First choice of treatment in @entity7 @entity0 is @entity1 ( @entity1 ). The effect of @entity1 has been shown to have limited influence on skeletal manifestations by poor penetration of musculoskeletal tissues by the enzyme derived from donor leucocytes. Aim of this study was to investigate the effect of @entity1 on the craniocervical junction (CCJ) in @entity7 @entity0 . We analysed retrospectively sequential magnetic resonance imaging (MRI) scans of 30 @entity0 with @entity7 treated by @entity1 since 1982 at the Royal Manchester @entity0 's Hospital, UK, in order to determine whether the @entity0 suffer from @entity8 . Results were compared with biochemical and clinical characteristics: Enzyme activity (EA), chimerism, urinary glycosaminoglycan (GAG) excretion and neurological status. Investigations were part of standard clinical procedures. Results are descriptive in presentation. In 26/30 @entity0 a @entity3 was feasible. The majority showed a normal dens length and an increase with age. Only 3/26 revealed a @entity8 . One of them had only partial donor engraftment (DE) with reduced EA, one of them suffered from @entity5 ( @entity5 ). One @entity0 with only partial DE and reduced EA presented with @entity4 until preadolescence but normalized later on. There may be a trend towards lower EA and the occurrence of DH in transplanted @entity6 @entity0 - perhaps the dosage of enzyme plays a role in the correction of skeletal complications in this @entity0 group. @entity1 @entity0 with incomplete DE and therefore lower EAs may require special attention and care.

title: The craniocervical junction following successful @entity1 for @entity7 ( XXXX ).

answer: @entity7


abstract: @entity3 proteins (HSPs) are among the most highly conserved and immunogenic proteins shared by microbial agents and mammals. @entity0 (h) @entity8 is upregulated under stress conditions and serves as a target for cross-reactive cytotoxic HSP-serum-antibodies. The present study evaluates the expressions of @entity8 and its homologue chlamydial (c) @entity8 in advanced @entity0 @entity1 and correlates intimal tissue-bound HSP expressions with circulating HSP-antibodies. Coronary atherectomy specimens retrieved from 100 primary target lesions of @entity0 with @entity4 ( @entity4 ; n  =  40) or @entity7 ( @entity7 ; n  =  60) were assessed immunohistochemically for the presence of @entity8 and cHSP60. In a subgroup (n  =  40), blood samples were tested for anti-Chl. pn.-IgG/IgA-titers and anti- @entity8 -antibody titers. Coronary plaques revealed immunoreactive @entity8 in 55% and cHSP60 in 45% of the lesions. Expression of both HSP homologues was significantly (each p  <  0.001) higher in @entity4 lesions compared with @entity7 lesions (7.4 vs. 1.2% and 6.0 vs. 1.1%). HSP homologues showed positive correlations both in @entity4 - and @entity7 -lesions (r  =  0.41, 0.33; p  <  0.05). cHSP60 showed no association with anti-Chl. pn.-IgG/IgA-titers, whereas expressions of both homologues correlated positive with anti- @entity8 -Ab titers (r  =  0.42, p  <  0.05; r  =  0.50, p  <  0.01). Intimal amounts of @entity8 homologues were associated with increased expressions of @entity5 , @entity6 . @entity0 and chlamydial @entity8 colocalize within @entity1 , most prevalent in lesions associated with @entity4 . Our data demonstrate a significant correlation between the intimal expressions of @entity8 homologues and serum @entity8 antibodies, thereby suggesting that humoral immune reactions may play an important role in @entity2 and plaque instability.

title: Prevalence of intimal XXXX protein 60 homologues in @entity4 and correlation with anti- @entity3 protein antibody titers.

answer: @entity3


abstract: @entity3 proteins (HSPs) are among the most highly conserved and immunogenic proteins shared by microbial agents and mammals. @entity0 (h) @entity8 is upregulated under stress conditions and serves as a target for cross-reactive cytotoxic HSP-serum-antibodies. The present study evaluates the expressions of @entity8 and its homologue chlamydial (c) @entity8 in advanced @entity0 @entity1 and correlates intimal tissue-bound HSP expressions with circulating HSP-antibodies. Coronary atherectomy specimens retrieved from 100 primary target lesions of @entity0 with @entity4 ( @entity4 ; n  =  40) or @entity7 ( @entity7 ; n  =  60) were assessed immunohistochemically for the presence of @entity8 and cHSP60. In a subgroup (n  =  40), blood samples were tested for anti-Chl. pn.-IgG/IgA-titers and anti- @entity8 -antibody titers. Coronary plaques revealed immunoreactive @entity8 in 55% and cHSP60 in 45% of the lesions. Expression of both HSP homologues was significantly (each p  <  0.001) higher in @entity4 lesions compared with @entity7 lesions (7.4 vs. 1.2% and 6.0 vs. 1.1%). HSP homologues showed positive correlations both in @entity4 - and @entity7 -lesions (r  =  0.41, 0.33; p  <  0.05). cHSP60 showed no association with anti-Chl. pn.-IgG/IgA-titers, whereas expressions of both homologues correlated positive with anti- @entity8 -Ab titers (r  =  0.42, p  <  0.05; r  =  0.50, p  <  0.01). Intimal amounts of @entity8 homologues were associated with increased expressions of @entity5 , @entity6 . @entity0 and chlamydial @entity8 colocalize within @entity1 , most prevalent in lesions associated with @entity4 . Our data demonstrate a significant correlation between the intimal expressions of @entity8 homologues and serum @entity8 antibodies, thereby suggesting that humoral immune reactions may play an important role in @entity2 and plaque instability.

title: Prevalence of intimal @entity3 protein 60 homologues in @entity4 and correlation with anti- XXXX protein antibody titers.

answer: @entity3


abstract: @entity3 proteins (HSPs) are among the most highly conserved and immunogenic proteins shared by microbial agents and mammals. @entity0 (h) @entity8 is upregulated under stress conditions and serves as a target for cross-reactive cytotoxic HSP-serum-antibodies. The present study evaluates the expressions of @entity8 and its homologue chlamydial (c) @entity8 in advanced @entity0 @entity1 and correlates intimal tissue-bound HSP expressions with circulating HSP-antibodies. Coronary atherectomy specimens retrieved from 100 primary target lesions of @entity0 with @entity4 ( @entity4 ; n  =  40) or @entity7 ( @entity7 ; n  =  60) were assessed immunohistochemically for the presence of @entity8 and cHSP60. In a subgroup (n  =  40), blood samples were tested for anti-Chl. pn.-IgG/IgA-titers and anti- @entity8 -antibody titers. Coronary plaques revealed immunoreactive @entity8 in 55% and cHSP60 in 45% of the lesions. Expression of both HSP homologues was significantly (each p  <  0.001) higher in @entity4 lesions compared with @entity7 lesions (7.4 vs. 1.2% and 6.0 vs. 1.1%). HSP homologues showed positive correlations both in @entity4 - and @entity7 -lesions (r  =  0.41, 0.33; p  <  0.05). cHSP60 showed no association with anti-Chl. pn.-IgG/IgA-titers, whereas expressions of both homologues correlated positive with anti- @entity8 -Ab titers (r  =  0.42, p  <  0.05; r  =  0.50, p  <  0.01). Intimal amounts of @entity8 homologues were associated with increased expressions of @entity5 , @entity6 . @entity0 and chlamydial @entity8 colocalize within @entity1 , most prevalent in lesions associated with @entity4 . Our data demonstrate a significant correlation between the intimal expressions of @entity8 homologues and serum @entity8 antibodies, thereby suggesting that humoral immune reactions may play an important role in @entity2 and plaque instability.

title: Prevalence of intimal @entity3 protein 60 homologues in XXXX and correlation with anti- @entity3 protein antibody titers.

answer: @entity4


abstract: BACKGROUND: Neonatal @entity7 remains a severe @entity1 with mortality rates varying between 10% and 15%. The clinical and bacteriologic features of @entity4 collected from January 2001 to December 2007 in a French national survey are presented here. METHODS: Cases of @entity4 were prospectively collected by a network of 252 pediatric wards covering 61% of French pediatric wards, associated with 168 microbiology laboratories. @entity4 was classified as early-onset (d0-d4) and late-onset (d5-d28). Statistical analyses were performed according to gestational age and weight at birth. RESULTS: A total of 444 cases of neonatal @entity7 were reported by 114 pediatric wards. Five cases were excluded from analysis. @entity5 ( @entity5 ) and @entity3 accounted respectively for 59% and 28% of the cases, followed by Gram-negative bacilli other than @entity3 (4%), other streptococci (4%), @entity6 (3%), and @entity8 (1.5%). @entity5 was the most common pathogen both in early-onset (77% vs. 18% for @entity3 ) and in late-onset @entity4 (50% vs. 33% for @entity3 ). Among preterm @entity0 , @entity3 was more commonly isolated (45% vs. 32% for @entity5 ), especially in very preterm @entity0 (54%). @entity5 was more often involved in @entity2 than @entity3 (41% vs. 25%). The overall mortality rate was 13% but reached 25% in preterm or small for gestational age @entity0 , regardless of the etiology. CONCLUSIONS: @entity5 was the dominant cause of neonatal @entity7 , with 77% of early-onset and 50% of late-onset cases. @entity3 was the most common bacteria in preterm @entity0 .

title: Neonatal XXXX : 444 Cases in 7 Years.

answer: @entity7


abstract: PURPOSE: The aim of research study was to evaluate the effect of corneal cross-linking (CXL) in the frame of @entity0 with progressive @entity3 1 year after treatment. METHODS: There were 40 eyes of 35 @entity0 with mean age 28, 45 +/- 9.3 (SD) (15 to 48 years) included in the study. @entity0 were treated with standard protocol of CXL with abrasion of corneal epithelium. Complete ophthalmological examination included best corrected spectacles visual acuity (BCSVA), slit-lamp microscopic finding, corneal topography and corneal thickness measured with ultrasound method was performed before, on the 5-th day, 1. 6., 12. month after CXL. We divided @entity0 according to the stage of @entity3 into 2 groups (stage I. and stage II.) and according to the age into 3 groups (until 20, from 21 to 39, over 40 years). RESULTS: In all treated eyes, the CXL was without relevant complications. The only complication was stromal haze of @entity1 . In the evaluation based on stage of @entity3 , in the first group any @entity0 became a haze of @entity1 in 1 year after CXL. In the second group 35.7% of @entity0 had a haze of @entity1 . The average BCSVA 1 year after treatment was improved in the 1. group about 5.38 letter and in the 2. group about 1.25 letter. Topographic analysis showed decrease of simulated keratometry and refraction (1. group--0.1 D, 2. group--0.17 D), maximal keratometry and refraction (1. group--0.67 D, 2. group--0.76 D). Minimal keratometry and refraction in the 1. group decreased (1.17 D) and increased in the 2. group (1.09 D). In the evaluation based on the age was haze monitored in the first group one year after CXL in 12.5% of @entity2 . In the second group was haze of @entity1 in 20% of eyes and in the third group consisting of @entity0 over 40 years old, in 50% of eyes. The average BCSVA was improved in the 1. group (2.85 letter), and in the 2. group (3.68 letter).The average BCSVA was decreased in the oldest @entity0 in about 1.43 letter. In the 1. and 2. group the topographic analysis showed decrease of simulated keratometry and refraction (1. group--0.12D, 2. group--0.21D), maximal keratometry and refraction (1. group--1.13 D, 2. group--0,68D), minimal keratometry and refraction (1. group--1.17D, 2. group--0,69 D). In the 3. group the topography analysis showed increase of simulated keratometry and refraction (0,8D), maximal keratometry and refraction (0,98D), minimal keratometry and refraction (0,28D). Corneal pachymetry remained stable in all researched groups of @entity0 . CONCLUSIONS: CXL is considered as safe procedure to stop progression of @entity3 also for @entity0 until 19 years old. The best effect and minimal complications were by @entity0 until 40 years old and by @entity0 with the I. grade.

title: [Corneal cross-linking--modern method of XXXX treatment].

answer: @entity3


abstract: BACKGROUND: Most of bayesian pharmacokinetic studies and the influence of clinical variables have been carried out in adults. PURPOSE: The aim was to estimate population-based pharmacokinetic of @entity3 ( @entity6 ) and to determine the effect of treatment and additional disease on its performance in @entity0 with @entity1 . MATERIAL AND METHODS: For the study steady-state serum concentrations of @entity6 were determined from 108 @entity1 @entity0 (44 females and 64 males) who were receiving the anticonvulsant as main drug of treatment with age range since 1 to 16 years (median 4y, 6m) and weight since 5.2 to 50 kg (median 17.5 kg). All @entity0 had their renal, hepatic and nutritional functions normal. One compartment model using interactive two-stage Bayesian approach was employed in the analysis. RESULTS; Population estimates of CL/F and V/F for @entity6 were 0.022 +/- 0.013 L/h and 0.217 +/- 0.134 L/kg, respectively. These estimates were significantly affected by weight, age, @entity4 ( @entity5 ) and @entity2 ( @entity2 ). The final regression models were: CL/F (L/h) = 0.0696 + 0.0031 (Age) + 0.0075 (Weight); and V/F (L) = 0.674 + 0.0308 (Age) + 0.0756 (Weight). Prediction of @entity6 serum concentration in other validation group revealed an important improvement in the predictive performance of @entity6 concentrations in comparison with the basic model that did not include any co-variables. CONCLUSIONS: Based on a population model of @entity0 with @entity1 , the pharmacokinetic of @entity6 could be altered by weight, age and the administration of @entity5 and additional @entity2 to @entity1 .

title: Effect of treatment and additional disease on pharmacokinetic of XXXX in @entity0 with @entity1 .

answer: @entity3


abstract: BACKGROUND: Most of bayesian pharmacokinetic studies and the influence of clinical variables have been carried out in adults. PURPOSE: The aim was to estimate population-based pharmacokinetic of @entity3 ( @entity6 ) and to determine the effect of treatment and additional disease on its performance in @entity0 with @entity1 . MATERIAL AND METHODS: For the study steady-state serum concentrations of @entity6 were determined from 108 @entity1 @entity0 (44 females and 64 males) who were receiving the anticonvulsant as main drug of treatment with age range since 1 to 16 years (median 4y, 6m) and weight since 5.2 to 50 kg (median 17.5 kg). All @entity0 had their renal, hepatic and nutritional functions normal. One compartment model using interactive two-stage Bayesian approach was employed in the analysis. RESULTS; Population estimates of CL/F and V/F for @entity6 were 0.022 +/- 0.013 L/h and 0.217 +/- 0.134 L/kg, respectively. These estimates were significantly affected by weight, age, @entity4 ( @entity5 ) and @entity2 ( @entity2 ). The final regression models were: CL/F (L/h) = 0.0696 + 0.0031 (Age) + 0.0075 (Weight); and V/F (L) = 0.674 + 0.0308 (Age) + 0.0756 (Weight). Prediction of @entity6 serum concentration in other validation group revealed an important improvement in the predictive performance of @entity6 concentrations in comparison with the basic model that did not include any co-variables. CONCLUSIONS: Based on a population model of @entity0 with @entity1 , the pharmacokinetic of @entity6 could be altered by weight, age and the administration of @entity5 and additional @entity2 to @entity1 .

title: Effect of treatment and additional disease on pharmacokinetic of @entity3 in @entity0 with XXXX .

answer: @entity1


abstract: BACKGROUND: Most of bayesian pharmacokinetic studies and the influence of clinical variables have been carried out in adults. PURPOSE: The aim was to estimate population-based pharmacokinetic of @entity3 ( @entity6 ) and to determine the effect of treatment and additional disease on its performance in @entity0 with @entity1 . MATERIAL AND METHODS: For the study steady-state serum concentrations of @entity6 were determined from 108 @entity1 @entity0 (44 females and 64 males) who were receiving the anticonvulsant as main drug of treatment with age range since 1 to 16 years (median 4y, 6m) and weight since 5.2 to 50 kg (median 17.5 kg). All @entity0 had their renal, hepatic and nutritional functions normal. One compartment model using interactive two-stage Bayesian approach was employed in the analysis. RESULTS; Population estimates of CL/F and V/F for @entity6 were 0.022 +/- 0.013 L/h and 0.217 +/- 0.134 L/kg, respectively. These estimates were significantly affected by weight, age, @entity4 ( @entity5 ) and @entity2 ( @entity2 ). The final regression models were: CL/F (L/h) = 0.0696 + 0.0031 (Age) + 0.0075 (Weight); and V/F (L) = 0.674 + 0.0308 (Age) + 0.0756 (Weight). Prediction of @entity6 serum concentration in other validation group revealed an important improvement in the predictive performance of @entity6 concentrations in comparison with the basic model that did not include any co-variables. CONCLUSIONS: Based on a population model of @entity0 with @entity1 , the pharmacokinetic of @entity6 could be altered by weight, age and the administration of @entity5 and additional @entity2 to @entity1 .

title: Effect of treatment and additional disease on pharmacokinetic of @entity3 in XXXX with @entity1 .

answer: @entity0


abstract: A 37-year-old housewife who had episodes of surgical removal for an @entity9 of her right leg 15 years ago, and total removal for right lung metastasis 2 years ago, was admitted to our service with complaints of @entity2 , @entity5 , @entity6 and recent memory disturbance which started about 4 months prior to admission. Neurological examination revealed @entity8 and disorientation. Left carotid angiography and CT scan showed @entity1 in the @entity4 . Presumptive diagnosis of metastatic @entity7 in the @entity4 was made in our service. Left fronto-parietal craniotomy was carried out on Feb. 22, 1977 and total removal for the @entity0 were made. Specimens of the @entity1 showed typical feature of @entity9 histologically. Postoperative course was well and she was discharged without @entity3 . Two years after the previous surgery for cerebral metastasis, another @entity0 was found in the @entity4 . Total removal for this solitary @entity0 was performed again. Histological and electron microscopical examination was made with this @entity1 specimen. Typical feature of @entity9 was confirmed. She was discharged with a marked improvement of her symptoms. At present, it has been passed about a year after the second surgery on her, she is doing well without @entity3 . Clinical features of @entity9 were discussed, especially with the comparison of clinical feature between the reported cases of Japan and the cases of foreign countries. Regarding the choice of the treatment of this @entity1 , total removal was seemed to be the best management. Therefore, all efforts should be focussed to discover in the earlier stage of this @entity1 .

title: [A case of XXXX with lung and cerebral metastasis (author's transl)].

answer: @entity9


abstract: MOTIVATION: High-throughput methods for detecting molecular interactions have produced large sets of biological network data with much more yet to come. Analogous to sequence alignment, efficient and reliable network alignment methods are expected to improve our understanding of biological systems. Unlike sequence alignment, network alignment is computationally intractable. Hence, devising efficient network alignment heuristics is currently a foremost challenge in computational biology. RESULTS: We introduce a novel network alignment algorithm, called @entity2 ( @entity2 ), which can integrate any number and type of similarity measures between network nodes (e.g. proteins), including, but not limited to, any topological network similarity measure, sequence similarity, functional similarity and structural similarity. Hence, we resolve the ties in similarity measures and find a combination of similarity measures yielding the largest contiguous (i.e. connected) and biologically sound alignments. @entity2 exposes the largest functional, connected regions of protein-protein interaction (PPI) network similarity to date: surprisingly, it reveals that 77.7% of proteins in the @entity1 high-confidence PPI network participate in such a subnetwork that is fully contained in the @entity0 high-confidence PPI network. This is the first demonstration that species as diverse as @entity1 and @entity0 contain so large, continuous regions of global network similarity. We apply @entity2 's alignments to predict functions of un-annotated proteins in @entity1 , @entity0 and bacteria validating our predictions in the literature. Furthermore, using network alignment scores for PPI networks of different herpes viruses, we reconstruct their phylogenetic relationship. This is the first time that phylogeny is exactly reconstructed from purely topological alignments of PPI networks. AVAILABILITY: Supplementary files and @entity2 executables: http://bio-nets.doc.ic.ac.uk/ @entity2 /.

title: Integrative network alignment reveals large regions of global network similarity in XXXX and @entity0 .

answer: @entity1


abstract: MOTIVATION: High-throughput methods for detecting molecular interactions have produced large sets of biological network data with much more yet to come. Analogous to sequence alignment, efficient and reliable network alignment methods are expected to improve our understanding of biological systems. Unlike sequence alignment, network alignment is computationally intractable. Hence, devising efficient network alignment heuristics is currently a foremost challenge in computational biology. RESULTS: We introduce a novel network alignment algorithm, called @entity2 ( @entity2 ), which can integrate any number and type of similarity measures between network nodes (e.g. proteins), including, but not limited to, any topological network similarity measure, sequence similarity, functional similarity and structural similarity. Hence, we resolve the ties in similarity measures and find a combination of similarity measures yielding the largest contiguous (i.e. connected) and biologically sound alignments. @entity2 exposes the largest functional, connected regions of protein-protein interaction (PPI) network similarity to date: surprisingly, it reveals that 77.7% of proteins in the @entity1 high-confidence PPI network participate in such a subnetwork that is fully contained in the @entity0 high-confidence PPI network. This is the first demonstration that species as diverse as @entity1 and @entity0 contain so large, continuous regions of global network similarity. We apply @entity2 's alignments to predict functions of un-annotated proteins in @entity1 , @entity0 and bacteria validating our predictions in the literature. Furthermore, using network alignment scores for PPI networks of different herpes viruses, we reconstruct their phylogenetic relationship. This is the first time that phylogeny is exactly reconstructed from purely topological alignments of PPI networks. AVAILABILITY: Supplementary files and @entity2 executables: http://bio-nets.doc.ic.ac.uk/ @entity2 /.

title: Integrative network alignment reveals large regions of global network similarity in @entity1 and XXXX .

answer: @entity0


abstract: OBJECTIVE: To assess the effectiveness of interventions in community and workplace settings to reduce sickness @entity2 in workers with @entity1 ( @entity1 ). METHODS: Relevant @entity0 ( @entity0 ) and cohort studies, published since 1990, were identified by screening citations from 35 earlier systematic reviews and by searching MEDLINE and Embase until April 2010. Effects were estimated by intervention category and other features, including study quality. RESULTS: Among 42 studies (including 34 @entity0 ), 27 assessed return to work (RTW), 21 duration of sickness absence and 5 job loss. Interventions included exercise therapy, behavioural change techniques, workplace adaptations and provision of additional services. Studies were typically small {median sample 107 [inter-quartile range (IQR) 77-148]} and limited in quality. Most interventions appeared beneficial: the median relative risk (RR) for RTW was 1.21 (IQR 1.00-1.60) and that for avoiding MSD-related job loss was 1.25 (IQR 1.06-1.71); the median reduction in sickness absence was 1.11 (IQR 0.32-3.20) days/month. However, effects were smaller in larger and better-quality studies, suggesting publication bias. No intervention was clearly superior, although effort-intensive interventions were less effective than simple ones. No cost-benefit analyses established statistically significant net economic benefits. CONCLUSION: As benefits are small and of doubtful cost-effectiveness, employers' practice should be guided by their value judgements about the uncertainties. Expensive interventions should be implemented only with rigorous cost-benefit evaluation planned from the outset. Future research should focus on the cost-effectiveness of simple, low-cost interventions, and further explore impacts on job retention.

title: Effectiveness of community- and workplace-based interventions to manage musculoskeletal-related sickness XXXX : a systematic review.

answer: @entity2


abstract: INTRODUCTION: In our institution, @entity0 with suspected @entity1 undergo multiple induced-sputum sampling for microscopy, culture and nucleic acid amplification (NAA) with the @entity5 (  ) Gen-probe assay. Those with negative induced-sputum results still suspected with @entity3 are then referred for bronchoscopy. We sought to determine the diagnostic yield of bronchoscopy in these @entity0 with negative initial induced-sputum results both via smear and @entity4 testing. METHODS: We identified 30 consecutive cases of suspected @entity1 between 2001 and 2007, who had undergone a diagnostic bronchoscopy after negative results on induced-sputum smears and the @entity5 (  ) Gen-probe on at least 2 samples. RESULTS: The cohort (M = 20 _ F = 10) had a median age of 37 (range 16-85 yrs); were predominantly foreign born (27/30); @entity2 -negative (29/30) individuals with strongly positive TST's (mean 18 + 5 mm). Induced-sputum cultures were negative for M- @entity3 in all @entity0 after a full 60-day incubation period. BAL was culture positive for M- @entity3 in 3/30 cases (10%) with 2 strains being pan-sensitive and the third being INH resistant. BAL microscopy with acid-fast smear (n = 30) and BAL Gen-probe (n = 23) were negative in all cases. A third of the @entity0 (9/27, 33%) with negative bronchoscopy results were treated for culture negative @entity3 . Treatment for @entity3 was initiated in 5/27 (18%) individuals whereas 13/27 (48%) received no further treatment. CONCLUSION: Bronchoscopy provided diagnostic confirmation of @entity1 in 10% of subjects at least 2 negative induced-sputum samples by smear microscopy and NAA testing.

title: Bronchoscopy in suspected XXXX with negative induced-sputum smear and @entity5 (  ) Gen-probe testing.

answer: @entity1


abstract: INTRODUCTION: In our institution, @entity0 with suspected @entity1 undergo multiple induced-sputum sampling for microscopy, culture and nucleic acid amplification (NAA) with the @entity5 (  ) Gen-probe assay. Those with negative induced-sputum results still suspected with @entity3 are then referred for bronchoscopy. We sought to determine the diagnostic yield of bronchoscopy in these @entity0 with negative initial induced-sputum results both via smear and @entity4 testing. METHODS: We identified 30 consecutive cases of suspected @entity1 between 2001 and 2007, who had undergone a diagnostic bronchoscopy after negative results on induced-sputum smears and the @entity5 (  ) Gen-probe on at least 2 samples. RESULTS: The cohort (M = 20 _ F = 10) had a median age of 37 (range 16-85 yrs); were predominantly foreign born (27/30); @entity2 -negative (29/30) individuals with strongly positive TST's (mean 18 + 5 mm). Induced-sputum cultures were negative for M- @entity3 in all @entity0 after a full 60-day incubation period. BAL was culture positive for M- @entity3 in 3/30 cases (10%) with 2 strains being pan-sensitive and the third being INH resistant. BAL microscopy with acid-fast smear (n = 30) and BAL Gen-probe (n = 23) were negative in all cases. A third of the @entity0 (9/27, 33%) with negative bronchoscopy results were treated for culture negative @entity3 . Treatment for @entity3 was initiated in 5/27 (18%) individuals whereas 13/27 (48%) received no further treatment. CONCLUSION: Bronchoscopy provided diagnostic confirmation of @entity1 in 10% of subjects at least 2 negative induced-sputum samples by smear microscopy and NAA testing.

title: Bronchoscopy in suspected @entity1 with negative induced-sputum smear and XXXX (  ) Gen-probe testing.

answer: @entity5


abstract: Fifteen @entity0 who presented with chronic cough as an isolated manifestation of @entity4 were evaluated for the presence of exercise-induced @entity3 . Pulmonary function tests using air and a helium/ @entity1 gas mixture were performed before exercise. Eight subjects were also evaluated by spirometry and maximum expiratory flow volume curves before and after @entity6 inhalation on a separate day. Ten subjects had normal pulmonary function tests at rest and five had isolated @entity2 . No significant changes in pulmonary function tests were recorded after inhalation of @entity6 in the eight subjects studied. Following exercise, all 15 subjects demonstrated changes in pulmonary function tests which were similar to those seen in @entity0 with mild exercise-induced @entity7 . After institution of @entity5 , exercise-induced decreases in flow rates low in the vital capacity were blocked in all subjects; however, several subjects had persistent mild decreases in peak flow. Within six months of discontinuing the @entity5 , cough recurred in 11 of the 15 subjects. Nine subjects were restudied after return of their cough. Exercise again resulted in @entity8 . Reinstitution of @entity5 eliminated the cough in these nine subjects. This study demonstrates that chronic cough in some @entity0 may be a manifestation of @entity3 . Both the cough and the reactivity can be blocked with @entity5 .

title: Chronic cough in @entity0 : a manifestation of XXXX .

answer: @entity3


abstract: Fifteen @entity0 who presented with chronic cough as an isolated manifestation of @entity4 were evaluated for the presence of exercise-induced @entity3 . Pulmonary function tests using air and a helium/ @entity1 gas mixture were performed before exercise. Eight subjects were also evaluated by spirometry and maximum expiratory flow volume curves before and after @entity6 inhalation on a separate day. Ten subjects had normal pulmonary function tests at rest and five had isolated @entity2 . No significant changes in pulmonary function tests were recorded after inhalation of @entity6 in the eight subjects studied. Following exercise, all 15 subjects demonstrated changes in pulmonary function tests which were similar to those seen in @entity0 with mild exercise-induced @entity7 . After institution of @entity5 , exercise-induced decreases in flow rates low in the vital capacity were blocked in all subjects; however, several subjects had persistent mild decreases in peak flow. Within six months of discontinuing the @entity5 , cough recurred in 11 of the 15 subjects. Nine subjects were restudied after return of their cough. Exercise again resulted in @entity8 . Reinstitution of @entity5 eliminated the cough in these nine subjects. This study demonstrates that chronic cough in some @entity0 may be a manifestation of @entity3 . Both the cough and the reactivity can be blocked with @entity5 .

title: Chronic cough in XXXX : a manifestation of @entity3 .

answer: @entity0


abstract: Plants from temperate regions are able to withstand freezing temperatures and to increase their freezing tolerance during exposure to low, but non-freezing, temperatures through a process known as cold acclimation. Key regulatory proteins in this process are the cold-induced @entity4 transcription factors which control many cold regulated genes. Although much work has focused on this signal transduction pathway, the details of its regulation and of its quantitative contribution to cold acclimation are still unclear. Here, we have used the large natural variation present in the 48 accessions of the Versailles core collection of @entity0 to further elucidate the function of the CBF transcription factors. CBF gene expression studies showed that the freezing sensitive accessions had mostly low expression levels 2h after transfer of plants to 5  C, while the most tolerant accessions showed a wide range of CBF expression levels. To investigate the quantitative contribution of CBF expression to plant freezing tolerance and low temperature growth performance, RNAi lines targeting all three CBF genes were produced in eight different accessions. We observed striking differences between different accessions in the effects that reduced CBF expression had on freezing tolerance, while effects on growth were generally too small to draw firm conclusions. Analysis of CBF expression indicated a tight co-regulation between @entity3 and @entity1 , while the relationship between the expression levels of @entity2 and @entity3 or @entity1 strongly depended on the genetic background of the RNAi lines. In agreement with the observed differences between the different accessions, QTL analyses with two different RIL populations indicated that QTL localisation varies strongly between populations. Collectively, these results show that both the regulation of the CBF genes and their relative contribution to freezing tolerance strongly depend on the accession studied. In addition, natural variation is suggested to be an interesting source of novel regulatory pathways and genes that may be useful in the future for improving plant freezing tolerance.

title: Natural variation in the freezing tolerance of XXXX : effects of RNAi-induced CBF depletion and QTL localisation vary among accessions.

answer: @entity0


abstract: BACKGROUND: Contrast-enhanced MRI (ceMRI) has impaired accuracy in the prediction of functional recovery after revascularisation in cases of intermediate myocardial viability. OBJECTIVE: To evaluate the predictive value of layer-specific @entity1 analysis for improvement in @entity2 after revascularisation. METHODS: In 132 @entity0 with @entity3 undergoing revascularisation, myocardial viability was assessed by pixel-tracking-derived @entity1 imaging and ceMRI. Peak systolic circumferential strain was determined for total wall thickness and for three @entity1 (endocardial, mid-myocardial and epicardial) in a 16-segment model. Analysis to predict recovery of function at 8  2 months after revascularisation was performed considering all dysfunctional segments or only segments with intermediate viability by ceMRI (hyperenhancement 25-75%, N=735 segments). RESULTS: Segments with functional recovery (N=568) had higher circumferential strain in all @entity1 and a smaller degree of hyperenhancement than segments without functional recovery (N=433). Analysis of all dysfunctional segments showed that the predictive accuracy for functional recovery was high for endocardial strain, total wall thickness strain and hyperenhancement by ceMRI (area under the curve (AUC) 0.883, 0.782 and 0.834, respectively). Considering only segments with intermediate viability by ceMRI, endocardial circumferential strain allowed prediction of functional recovery with higher accuracy (specificity 75%, sensitivity 78%, AUC=0.811, 95% CI 0.776 to 0.851) than hyperenhancement analysis (specificity 59%, sensitivity 72%, AUC=0.705, 95% CI 0.659 to 0.747, p<0.05). CONCLUSION: Analysis of layer-specific myocardial function using deformation imaging allows accurate identification of reversible @entity1 . In segments with intermediate viability analysis of layer-specific deformation may have special advantages for prediction of functional recovery.

title: Layer-specific analysis of myocardial function for accurate prediction of reversible XXXX in intermediate viability defined by contrast-enhanced MRI.

answer: @entity2


abstract: Hereditary causes are decisive for the development of unsystematic forms of @entity1 . In periodic @entity2 a dominant, and in affective @entity3 a recessive hereditary succession must be assumed. In cataphasia, the findings do not give any clear information about the hereditary succession. In all three forms, considerable variations of the manifestations are found. Imperative indications have been observed suggesting that the brother-and-sister constellations, which have scientifically been too much neglected, have an essential share in these phenomena. In periodic @entity2 , the lack of brothers and sisters and in particular a lack of elder sisters proved to be an essential factor. Affective paraphrenics frequently are the youngest of the brothers and sisters in a family. An attempt has been made to give an explanation of these findings. Further external influences proved to be essential. In @entity0 suffering from cataphasia, for example, the origin from rural districts and, on the other hand, the origin from a large town seem to play a role.

title: [What increases the probability of manifestation in hereditary XXXX ?].

answer: @entity1


abstract: OBJECTIVE: Studies provide conflicting results about the impact of comorbid conditions on the quality of @entity3 care. We assessed the effect of comorbidity type (concordant, discordant, or both) on the receipt of guideline-recommended care among @entity0 with @entity1 . RESEARCH DESIGN: @entity0 were assigned to 1 of 4 condition groups: @entity1 -concordant ( @entity2 , @entity8 , @entity6 ), and/or @entity1 -discordant ( @entity7 , @entity5 , chronic obstructive pulmonary disease) conditions, or neither. We evaluated hemoglobin A1c, blood pressure, and low-density lipoprotein @entity4 readings at index and measured overall good quality of @entity1 care, including a 6-month follow-up interval. We assessed the effect of condition group on overall good quality of care with logistic regression and generalized ordered logistic regression. RESULTS: We assigned 35,872 @entity0 to the @entity1 comorbid condition groups, ranging from 2.0% in the discordant-only group to 58.0% in the concordant-only group. @entity0 with both types of conditions were more likely than those with no comorbidities to receive overall good quality for glycemic [odds ratio (OR), 2.13; 95% confidence interval (CI), 1.86-2.41], blood pressure (OR, 1.62; 95% CI, 1.40-1.84), and low-density lipoprotein @entity4 (OR, 3.57; 95% CI, 3.08-4.05) control within 6 months of an index visit. They were also more likely to receive overall good quality for all 3 quality measures combined (OR, 2.17; 95% CI, 1.96-2.39). CONCLUSIONS: @entity0 with the greatest clinical complexity were more likely than less complex @entity0 to receive high quality @entity1 care, suggesting that increased complexity does not necessarily predispose chronically ill @entity0 to receiving poorer care. However, caution should be used in treating certain @entity0 groups, such as the elderly, for whom adherence to multiple condition-specific guidelines may lack benefit or cause harm.

title: Impact of comorbidity type on measures of quality for XXXX care.

answer: @entity1


abstract: STUDY DESIGN: Case report including technical note. OBJECTIVE: We describe 2 cases of intraoperative cervical plate @entity3 treated by modified screw augmentation using polymethylmethacrylate ( @entity5 ), which used the anchoring effect of hardened @entity5 . SUMMARY OF BACKGROUND DATA: Intraoperative @entity3 during cervical plating is not rare. @entity5 augmentation for a damaged pilot hole is one of the rescue techniques in such a case. METHODS: A 52-year-old @entity0 who had complained of @entity4 and left @entity2 underwent anterior cervical discectomy and plating with cage at the level of C6/7. An 82-year-old @entity0 presenting bilateral arm weakness and @entity2 after @entity1 underwent the same operation at @entity6 . Both of them showed intraoperative @entity3 , which was rectified by modified screw augmentation with @entity5 . The difference between this technique and conventional @entity5 augmentation is the anchoring effect of hardened @entity5 . This technique does not need a new screw trajectory, but uses the existing dead space around the loosened screw. After filling the dead space with about 0.5 mL of @entity5 , we inserted a small-sized screw. Once the @entity5 hardened, we could remove the small screw and insert a thicker screw along the existing screw thread to increase the screws' pullout strength and achieve rigid fixation of plate. RESULTS: The condition of both @entity0 improved without any instrument failure. In the first case, the visual analog scale and Neck Disability Index improved from 10 to 1 and from 64% to 2%, respectively. In the other @entity0 , the visual analog scale and Neck Disability Index improved from 10 to 4 and from 66% to 40%, respectively. X-ray at 6-month follow-up showed no evidence of @entity3 . CONCLUSIONS: This modified @entity5 augmentation is a simple, safe, and promising surgical technique to correct intraoperative @entity3 during cervical plating.

title: Modified polymethylmethacrylate cervical plate and screw augmentation technique for intraoperative XXXX .

answer: @entity3


abstract: OBJECTIVE: Preeclampsia is associated with cardiovascular @entity3 events later in life. Impaired arterial elasticity is considered to be a marker of @entity2 and to be involved in the @entity3 process. We investigated whether previously preeclamptic @entity0 have lower arterial elasticity indices in comparison with controls. DESIGN: Case-control study. SETTING: University Medical Center Groningen, the Netherlands. SAMPLE: 14 non-pregnant @entity0 with a history of early-onset @entity5 (cases) and 16 non-pregnant @entity0 (controls) with an uncomplicated pregnancy in 2003-2004. METHODS: Measurement of radial artery elasticity indices combined with the brachial blood pressure using pulse wave contour analysis. The assessment of traditional risk factors for @entity1 ( @entity1 ) including body mass index, serum high-sensitivity C-reactive protein (hsCRP), serum insulin and plasma @entity4 . MEAN OUTCOME MEASURES: Arterial elasticity indices and traditional risk factors for @entity1 in cases and controls. RESULTS: Arterial elasticity was impaired in cases as compared with controls. Body mass index, blood pressure, pulse pressure, hsCRP and @entity6 were significantly higher in cases. CONCLUSION: Arterial elasticity indices are reduced in formerly preeclamptic @entity0 , indicating @entity2 . This and the more established risk factors for @entity1 are likely to contribute to a higher risk of @entity1 in @entity0 with a history of early-onset @entity5 .

title: Decreased arterial elasticity in formerly early-onset preeclamptic XXXX .

answer: @entity0