abstract: BACKGROUND: Physical activity improves @entity1 and function among individuals with @entity4 ( @entity3 ), but most @entity0 with this condition are inactive. Physical therapists play a key role in helping @entity0 with knee @entity3 to increase appropriate physical activity. However, health care access issues, financial constraints, and other factors impede some @entity0 from receiving physical therapy (PT) for knee @entity3 . A need exists to develop and evaluate other methods to provide physical activity instruction and support to @entity0 with knee @entity3 . This study is examining the effectiveness of an internet-based exercise training (IBET) program designed for knee @entity3 , designed by physical therapists and other clinicians. METHODS/DESIGN: This is a randomized controlled trial of 350 @entity0 with symptomatic knee @entity3 , allocated to three groups: IBET, standard PT, and a wait list (WL) control group (in a 2:2:1 ratio, respectively). The study was funded by the @entity0 Centered Outcomes Research Institute, which conducted a peer review of the proposal. The IBET program provides @entity0 with a tailored exercise program (based on functional level, symptoms, and current activity), video demonstrations of exercises, and guidance for appropriate exercise progression. The PT group receives up to 8 individual visits with a physical therapist, mirroring standard practice for knee @entity3 and with an emphasis on a home exercise program. Outcomes are assessed at baseline, 4  months (primary time point) and 12  months (to assess maintenance of treatment effects). The primary outcome is the Western Ontario and McMaster Universities @entity3 Index, and secondary outcomes include objective physical function, satisfaction with physical function, physical activity, @entity2 and global assessment of change. Linear mixed models will be used to compare both the IBET and standard PT groups to the WL control group, examine whether IBET is non-inferior to PT (a treatment that has an established evidence base for knee @entity3 ), and explore whether @entity0 characteristics are associated with differential effects of IBET and/or standard PT. This research is in compliance with the Helsinki Declaration and was approved by the Institutional Review Board of the University of North Carolina at Chapel Hill. DISCUSSION: The IBET program could be disseminated widely at relatively low cost and could be an important resource for helping @entity0 with knee @entity3 to adopt and maintain appropriate physical activity. This trial will provide an important evaluation of the effectiveness of this IBET program for knee @entity3 . TRIAL REGISTRATION: NCT02312713.

title: Physical therapy vs. internet-based exercise training (PATH-IN) for @entity0 with XXXX : study protocol of a randomized controlled trial.

answer: @entity4


abstract: BACKGROUND: Physical activity improves @entity1 and function among individuals with @entity4 ( @entity3 ), but most @entity0 with this condition are inactive. Physical therapists play a key role in helping @entity0 with knee @entity3 to increase appropriate physical activity. However, health care access issues, financial constraints, and other factors impede some @entity0 from receiving physical therapy (PT) for knee @entity3 . A need exists to develop and evaluate other methods to provide physical activity instruction and support to @entity0 with knee @entity3 . This study is examining the effectiveness of an internet-based exercise training (IBET) program designed for knee @entity3 , designed by physical therapists and other clinicians. METHODS/DESIGN: This is a randomized controlled trial of 350 @entity0 with symptomatic knee @entity3 , allocated to three groups: IBET, standard PT, and a wait list (WL) control group (in a 2:2:1 ratio, respectively). The study was funded by the @entity0 Centered Outcomes Research Institute, which conducted a peer review of the proposal. The IBET program provides @entity0 with a tailored exercise program (based on functional level, symptoms, and current activity), video demonstrations of exercises, and guidance for appropriate exercise progression. The PT group receives up to 8 individual visits with a physical therapist, mirroring standard practice for knee @entity3 and with an emphasis on a home exercise program. Outcomes are assessed at baseline, 4  months (primary time point) and 12  months (to assess maintenance of treatment effects). The primary outcome is the Western Ontario and McMaster Universities @entity3 Index, and secondary outcomes include objective physical function, satisfaction with physical function, physical activity, @entity2 and global assessment of change. Linear mixed models will be used to compare both the IBET and standard PT groups to the WL control group, examine whether IBET is non-inferior to PT (a treatment that has an established evidence base for knee @entity3 ), and explore whether @entity0 characteristics are associated with differential effects of IBET and/or standard PT. This research is in compliance with the Helsinki Declaration and was approved by the Institutional Review Board of the University of North Carolina at Chapel Hill. DISCUSSION: The IBET program could be disseminated widely at relatively low cost and could be an important resource for helping @entity0 with knee @entity3 to adopt and maintain appropriate physical activity. This trial will provide an important evaluation of the effectiveness of this IBET program for knee @entity3 . TRIAL REGISTRATION: NCT02312713.

title: Physical therapy vs. internet-based exercise training (PATH-IN) for XXXX with @entity4 : study protocol of a randomized controlled trial.

answer: @entity0


abstract: These experiments queried the potential for developmental change in the positive and negative feedback sensitivities of LH secretion to @entity1 . Serum LH levels were compared in juvenile, peripubertal, and adult female @entity0 after ovariectomy and challenge with a variety of 4-day @entity2 treatments. Since male stimuli accelerate the attainment of puberty in this species, comparisons also were made between age- and weight-matched groups of pre- vs. postpubertal females, obtained by housing them in either the presence or absence of males. The following conclusions were derived from eight experiments. 1) Progressively more @entity1 is required to suppress the postovariectomy rise in serum LH as the female @entity0 develops the juvenile stage to full adulthood. 2) This slow, progressive change is due in part to a steadily increasing capacity to secrete LH when unhindered by any negative feedback regulation by the ovary; it is not due to developmental changes in @entity1 metabolism. 3) The LH surging mechanism is functional and already coupled to its circadian oscillator in the juvenile @entity0 , but surges of adult magnitude could not be induced with exogenous @entity2 until the peripubertal period. 4) The @entity1 requirements for preovulatory LH surging change markedly after the peripubertal stage of development; a wide range of temporal changes in blood @entity1 levels will elicit LH surging in the adult @entity0 , but the immature female requires a rigid pattern of change involving only a narrow range of blood levels of this @entity2 . 5) Exposure of peripubertal females to male stimuli alters neither their negative feedback sensitivity to @entity1 nor their @entity3 requirements for LH surging. These conclusions are integrated into two working models that focus first on the @entity3 requirements for LH surging in the adult @entity0 , and second on the maturation of this process and the attainment of pubertal ovulation. (Endocrinology 108: 506, 1981)

title: The regulation of luteinizing hormone secretion by XXXX : relationships among negative feedback, surge potential, and male stimulation in juvenile, peripubertal, and adult female @entity0 .

answer: @entity3


abstract: These experiments queried the potential for developmental change in the positive and negative feedback sensitivities of LH secretion to @entity1 . Serum LH levels were compared in juvenile, peripubertal, and adult female @entity0 after ovariectomy and challenge with a variety of 4-day @entity2 treatments. Since male stimuli accelerate the attainment of puberty in this species, comparisons also were made between age- and weight-matched groups of pre- vs. postpubertal females, obtained by housing them in either the presence or absence of males. The following conclusions were derived from eight experiments. 1) Progressively more @entity1 is required to suppress the postovariectomy rise in serum LH as the female @entity0 develops the juvenile stage to full adulthood. 2) This slow, progressive change is due in part to a steadily increasing capacity to secrete LH when unhindered by any negative feedback regulation by the ovary; it is not due to developmental changes in @entity1 metabolism. 3) The LH surging mechanism is functional and already coupled to its circadian oscillator in the juvenile @entity0 , but surges of adult magnitude could not be induced with exogenous @entity2 until the peripubertal period. 4) The @entity1 requirements for preovulatory LH surging change markedly after the peripubertal stage of development; a wide range of temporal changes in blood @entity1 levels will elicit LH surging in the adult @entity0 , but the immature female requires a rigid pattern of change involving only a narrow range of blood levels of this @entity2 . 5) Exposure of peripubertal females to male stimuli alters neither their negative feedback sensitivity to @entity1 nor their @entity3 requirements for LH surging. These conclusions are integrated into two working models that focus first on the @entity3 requirements for LH surging in the adult @entity0 , and second on the maturation of this process and the attainment of pubertal ovulation. (Endocrinology 108: 506, 1981)

title: The regulation of luteinizing hormone secretion by @entity3 : relationships among negative feedback, surge potential, and male stimulation in juvenile, peripubertal, and adult female XXXX .

answer: @entity0


abstract: Objective. Basilar artery (BA) terminates in right and left posterior cerebral arteries (PCAs). Each @entity4 supplies respective occipital lobe of the cerebrum. The present study is designed to know the morphology, morphometry, branching pattern, and symmetry of @entity4 . Methods. The study included 340 PCAs dissected from 170 @entity0 cadaveric brains. Results. Morphological variations of P1 segment included, @entity3 (2.35%), @entity2 (5.29%), duplication (2.35%), fenestration (1.17%), and common trunk shared with SCA (1.76%). Morphological variations of origin of P2 segment included direct origin of it from BA (1.17%) and @entity5 (2.35%). Unusually, two P2 segments, each arising separately from BA and @entity5 , were observed in 1.17%. Unilateral two P2 segments from CW were found in 0.58%. Morphological variations of course of P2 were duplication (0.58%), fenestration (0.58%), and @entity1 (1.76%). Unilateral P2 either adult or fetal was seen in 4.71%. The group II branching pattern was found to be most common. Asymmetry of P2 was 40%. Morphometry of P2 revealed mean length of 52   mm and mean diameter of 2.7   mm. Conclusion. The present study provides the complete anatomical description of @entity4 regarding morphology, morphometry, symmetry, and its branching pattern. Awareness of these variations is likely to be useful in cerebrovascular procedures.

title: Study of Posterior Cerebral Artery in XXXX Cadaveric Brain.

answer: @entity0


abstract: OBJECTIVE: To better characterize the genomics of @entity0 with biochemical recurrence (BCR) who have metastatic disease progression in order to improve treatment decisions for @entity4 . METHODS: The expression profiles of three clinical outcome groups after radical prostatectomy (RP) were compared: those with @entity3 ( @entity3 ; n = 108); those with BCR (rise in @entity6 [PSA] level without @entity1 ; n = 163); and those with @entity1 (n = 192). The @entity0 were profiled using @entity0 Exon 1.0 ST microarrays, and outcomes were supported by a median 18  years of follow-up. A @entity1 signature was defined and verified in an independent RP cohort to ensure the robustness of the signature. Furthermore, bioinformatics characterization of the signature was conducted to decipher its biology. RESULTS: Minimal gene expression differences were observed between adjuvant treatment-na  ve @entity0 in the @entity3 group and @entity0 without @entity1 in the BCR group. More than 95% of the differentially expressed genes ( @entity1 signature) were found in comparisons between primary @entity2 of @entity1 @entity0 and the two other outcome groups. The @entity1 signature was validated in an independent cohort and was significantly associated with cell cycle genes, ubiquitin-mediated proteolysis, DNA repair, @entity5 , G-protein coupled and NOTCH signal transduction pathways. CONCLUSION: This study shows that @entity1 development after BCR is associated with a distinct transcriptional programme that can be detected in the primary @entity2 . @entity0 with @entity3 and BCR have highly similar transcriptional profiles, suggesting that measurement of PSA on its own is a poor surrogate for lethal disease. Use of genomic testing in @entity0 undergoing RP with an initial rise in PSA level may be useful to improve secondary therapy decision-making.

title: Clinical and genomic analysis of XXXX progression with a background of  postoperative biochemical recurrence.

answer: @entity4


abstract: UNASSIGNED: Identification and diagnosis of Harris lines (HLs) is usually achieved using radiography. To date, histological methods have been mainly implemented in research exploring the underlying processes of @entity1 deposition using longitudinal sections taken from animal bone. Here, a new insight into @entity1 formation is provided following transverse histological sectioning in a @entity0 specimen. A distinct @entity1 was identified macroscopically, and from a radiograph, in a left distal tibia taken from an adult @entity0 male. Transverse sections were taken through the @entity1 , and also from trabeculae immediately superior and inferior to the @entity1 . Thin sections were produced following standard histological procedures. Micrographs were captured using a digital microscope camera. Trabeculae immediately superior and inferior to the @entity1 displayed no indication of abnormal growth, exhibiting abundant osteocyte lacunae and a lamellar structure. However, the micro-anatomy of the @entity1 was characterised by the following three main features: (1) non-lamellar appearance, (2) a complete lack of osteocyte lacunae, and (3) presence of irregularly distributed tubular structures. These three histological features indicate a specific process of bone deposition, implying that trapping of osteoblasts may not take place during @entity1 formation. Pictorial and descriptive records of @entity1 histology are provided, aiding current understanding about the nature of @entity1 , its identification from histology, and serving as a reference point for future comparative research.

title: Histology of a Harris line in a XXXX distal tibia.

answer: @entity0


abstract: AIM: To conduct a systematic review of studies on early probiotic supplementation to prevent @entity3 ( @entity3 ). METHODS: Using the Cochrane systematic review strategy we searched PubMed, EMBASE, CENTRAL, CINAHL, and the conference proceedings of the Pediatric American Society meetings and trial registries in December 2014. Randomised controlled trials (RCTs) and non RCTs of probiotic supplementation to the mother and/or @entity0 for a minimum duration of 4 wk were selected. Of these, studies that reported on @entity3 or its components ( @entity2 , raised blood pressure, @entity6 , @entity5 ) in @entity0 between 2-19 years were to be eligible for inclusion in the review. Risk of bias (ROB) in selected RCTs and quality assessment of non-RCT studies were to be assessed by the Cochrane ROB assessment table and New Castle Ottawa scale. RESULTS: There were no studies on early probiotic administration for prevention of @entity1 ( @entity1 ). Follow up studies of two placebo controlled RCTs (n = 233) reported on the effects of early probiotics on one or more components of @entity3 in @entity0 aged 2-19 years. Meta-analysis of those two studies could not be performed due to differences in the @entity0 population, type of outcomes studied and the timing of their assessment. Assessment of childhood metabolic outcomes was not the primary objective of these studies. The first study that assessed the effects of prenatal and postnatal supplementation of @entity4 on body mass index till 10 years, did not report a significant benefit. In the second study, @entity7 19 was supplemented to healthy term @entity0 from 4-13 mo. No significant effect on body mass index, body composition or metabolic markers was detected. CONCLUSION: Current evidence on early probiotic administration to prevent @entity1 is inadequate. Gaps in knowledge need to be addressed before large RCTs can be planned.

title: Early probiotics to prevent XXXX : A systematic review.

answer: @entity3


abstract: UNASSIGNED: Opioids reduce injury from @entity4 -reperfusion in @entity0 . In experimental models, this mechanism involves @entity9 inhibition. @entity10 regulates mitochondrial protein import, with @entity9 inhibition increasing @entity10 mitochondrial content. Therefore, we determined whether @entity6 -induced cardioprotection is mediated by @entity10 and if the protective effect is downstream of @entity9 inhibition. Male @entity1 , aged 8-10 weeks, were subjected to an in vivo @entity4 -reperfusion injury protocol involving 30 minutes of @entity2 followed by 2 hours of reperfusion. Hemodynamics were continually monitored and @entity3 size determined. @entity1 received @entity6 (0.3   mg/kg), the @entity9 inhibitor, @entity11 (0.6   mg/kg), or saline, 10 minutes prior to @entity2 . Some @entity1 received selective @entity10 inhibitors, @entity12 (0.3   mg/kg), or @entity7 ( @entity8 , 0.6   mg/kg) alone or 5 minutes prior to @entity6 or @entity11 . @entity6 reduced @entity3 size when compared to control (42    2% versus 60    1%). This protection was abolished by prior treatment of @entity12 or @entity8 (59    1%, 56    2%). @entity9 inhibition also reduced @entity3 size (41    2%) with @entity10 inhibition by @entity12 or @entity8 partially inhibiting @entity11 -induced @entity5 size reduction (54    3%, 47    1%, resp.). These data suggest that opioid-induced cardioprotection is mediated by @entity10 . Part of this protection afforded by @entity10 is downstream of @entity9 , potentially via the HSP-TOM mitochondrial import pathway.

title: XXXX Reduces @entity3 via Heat Shock Protein 90 in Rodents.

answer: @entity6


abstract: UNASSIGNED: Opioids reduce injury from @entity4 -reperfusion in @entity0 . In experimental models, this mechanism involves @entity9 inhibition. @entity10 regulates mitochondrial protein import, with @entity9 inhibition increasing @entity10 mitochondrial content. Therefore, we determined whether @entity6 -induced cardioprotection is mediated by @entity10 and if the protective effect is downstream of @entity9 inhibition. Male @entity1 , aged 8-10 weeks, were subjected to an in vivo @entity4 -reperfusion injury protocol involving 30 minutes of @entity2 followed by 2 hours of reperfusion. Hemodynamics were continually monitored and @entity3 size determined. @entity1 received @entity6 (0.3   mg/kg), the @entity9 inhibitor, @entity11 (0.6   mg/kg), or saline, 10 minutes prior to @entity2 . Some @entity1 received selective @entity10 inhibitors, @entity12 (0.3   mg/kg), or @entity7 ( @entity8 , 0.6   mg/kg) alone or 5 minutes prior to @entity6 or @entity11 . @entity6 reduced @entity3 size when compared to control (42    2% versus 60    1%). This protection was abolished by prior treatment of @entity12 or @entity8 (59    1%, 56    2%). @entity9 inhibition also reduced @entity3 size (41    2%) with @entity10 inhibition by @entity12 or @entity8 partially inhibiting @entity11 -induced @entity5 size reduction (54    3%, 47    1%, resp.). These data suggest that opioid-induced cardioprotection is mediated by @entity10 . Part of this protection afforded by @entity10 is downstream of @entity9 , potentially via the HSP-TOM mitochondrial import pathway.

title: @entity6 Reduces XXXX via Heat Shock Protein 90 in Rodents.

answer: @entity3


abstract: A 2(3) factorial arrangement of treatments was utilized to determine effects of postweaning @entity1 implantation, breed (Angus vs Limousin) and castration (bull vs steer) on growth, behavior and carcass traits. An initial slaughter group was used to account for breed differences in composition and to determine fat and lean growth in the 9-10-11th rib section ( @entity2 ). The remaining @entity0 were fed a finishing diet to a fat end point of .76 cm, as determined by a backfat probe. Control bulls outgained (P less than .01) control steers both to the first kill date and over the entire test and did not require significantly more time to reach the fat end point. The implant did not influence gain in bulls but did increase gain in steers. Angus and Limousins were similar in growth rate for the first 126 d before the first slaughter date. Limousins required more (P less than .01) time to reach the fat end point. Bulls and Limousins produced heavier (P less than .01) carcasses and larger rib eyes (P less than .05; bulls; P less than .01; Limousins). Steers and Angus had higher (P less than .01) marbling scores and lower bone maturity. Implanting decreased (P less than .05) marbling and increased carcass maturity. Small but significant shifts in carcass wholesale cut weight distribution were found between breed and sex condition groups. Bulls and Limousins had greater lean growth in the @entity2 . Bulls and steers were similar in fat growth, but Angus exceeded Limousin in this trait. @entity1 reduced scrotal circumference (P less than .01) and testicle weight at slaughter (P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Influence of XXXX implants on growth, behavior and carcass traits in Angus and Limousin bulls and steers.

answer: @entity1


abstract: OBJECTIVES: This review is to explore whether potential gene interactions in the cell cycles of gametes, zygotes, and @entity1 ( @entity1 ) cells are associated with the development of @entity0 . METHODS: MEDPILOT at the Central Library of the University of Cologne, Germany (Zentralbibliothek K  ln) that covers 5,800 international medical journals and 4,300 E-journals was used to collect data. The initial searches were done in December 2012 and additional searches in October 2013-May 2015. The search terms included " @entity0 development," "gene interaction," and " @entity1 cells," and the time period was between 1998 and 2015. A total of 147 articles in English language only were included in this review. RESULTS: Transgenerational gene translation is implemented in the zygote through interactions of epigenetic isoforms of transcription factors (TFs) from parental gametes, predominantly during the first two zygote cleavages. Pluripotent transcription factors may provide interacting links with mutated genes during zygote-to- @entity1 cell switches. Translation of post-transcriptional carcinogenic genes is implemented by abnormally spliced, @entity0 -specific isoforms of gene-encoded mRNA/non-coding RNA variants of TFs employing de novo gene synthesis and neofunctionalization. Post-translationally, mutated genes are preserved in pre-neoplastic @entity1 cell subpopulations that can give rise to overt @entity0 stem cells. Thus, TFs operate as cell/disease-specific epigenetic messengers triggering clinical expression of @entity0 . CONCLUSION: Potential gene interactions in the cell cycle of gametes, zygotes, and @entity1 cells may play some roles in the development of @entity0 .

title: Potential Gene Interactions in the Cell Cycles of Gametes, Zygotes, Embryonic Stem Cells and the Development of XXXX .

answer: @entity0


abstract: OBJECTIVE: To evaluate a sequential screening method's efficacy in predicting @entity2 (PTE) after gynecologic surgery. METHODS: A prospective study employing a two-stage screening process was conducted among consecutive asymptomatic adults who underwent outpatient evaluation for gynecologic surgery at Nara Medical University Hospital, Japan, between April 1, 2004, and December 31, 2013. @entity0 with a preoperative plasma D-dimer level greater than or equal to 1.0 g/mL underwent compression ultrasonography of the lower extremities. The primary outcome measure was postoperative detection of symptomatic PTE. RESULTS: Overall, 1729 @entity0 were included. The mean D-dimer level was 1.7  3.3 g/mL. Compression ultrasonography was conducted among 470 (27.1%) @entity0 with positive D-dimer test results; symptomatic @entity1 ( @entity1 ) was preoperatively detected among 94 (20.0%) of them. @entity0 with @entity1 (n=94) had higher D-dimer levels than @entity0 (n=1635) without (7.8  12.8 g/mL vs 1.1  1.8 g/mL; P<0.001). Despite anticoagulant therapy, symptomatic PTE was detected postoperatively among two of these 94 @entity0 . Symptomatic PTE was also detected among four of 376 @entity0 with positive D-dimer test results but no evidence of @entity1 by ultrasonography. No clinical onset of postoperative PTE was observed among 1259 @entity0 with D-dimer levels below the cut-off value. CONCLUSION: The PROVEN screening strategy (Preoperative surveillance using a sequential strategy) was ineffective at predicting postoperative symptomatic PTE.

title: Sequential screening to predict XXXX after gynecologic surgery in Nara, Japan.

answer: @entity2


abstract: UNASSIGNED: @entity7 ( @entity7 ) is a common @entity2 . Our study was to analyze clinical features of @entity7 and evaluate whether aortic valve @entity5 score (AVCS) was a reliable marker for @entity6 ( @entity6 ) in @entity0 with @entity7 . 101 @entity0 with @entity7 who both underwent echocardiology and cardiac computed tomography (CT) scan in our institution were included. Basic clinical data, haemodynamic feature, aortic valve and coronary @entity5 score were collected and compared among @entity0 with different valve function and different degree of @entity6 . Risk factors related to severe @entity6 were evaluated by logistic regression, and a receiver operative characteristic curve was used to determine the cutoff @entity5 score greater than which the diagnosis of severe @entity6 was optimized. @entity0 with @entity3 ( @entity3 ) were younger and demonstrated larger aortic annulus and @entity1 compared with @entity0 with other @entity4 . Aortic valve @entity5 score was higher in @entity0 with @entity6 than with @entity3 . For @entity0 with different degree of @entity6 , there were statistical significances in the value of age, aortic valve @entity5 score and coronary @entity5 score. AVCS was positively related to severe @entity6 with an odd ratio of 1.286 (95  % CI 1.099-1.504) by every 300 points increase. AVCS was also a strong predictor for severe @entity6 with area under the curve 0.855 with a cutoff value of 897 (sensitivity 86.7  %, specificity 72.2  %). Conclusively, aortic @entity5 score calculated by quantitative CT is a reliable marker in evaluating severity of @entity6 .

title: The significance of aortic valve calcification in @entity0 with XXXX .

answer: @entity7


abstract: UNASSIGNED: @entity7 ( @entity7 ) is a common @entity2 . Our study was to analyze clinical features of @entity7 and evaluate whether aortic valve @entity5 score (AVCS) was a reliable marker for @entity6 ( @entity6 ) in @entity0 with @entity7 . 101 @entity0 with @entity7 who both underwent echocardiology and cardiac computed tomography (CT) scan in our institution were included. Basic clinical data, haemodynamic feature, aortic valve and coronary @entity5 score were collected and compared among @entity0 with different valve function and different degree of @entity6 . Risk factors related to severe @entity6 were evaluated by logistic regression, and a receiver operative characteristic curve was used to determine the cutoff @entity5 score greater than which the diagnosis of severe @entity6 was optimized. @entity0 with @entity3 ( @entity3 ) were younger and demonstrated larger aortic annulus and @entity1 compared with @entity0 with other @entity4 . Aortic valve @entity5 score was higher in @entity0 with @entity6 than with @entity3 . For @entity0 with different degree of @entity6 , there were statistical significances in the value of age, aortic valve @entity5 score and coronary @entity5 score. AVCS was positively related to severe @entity6 with an odd ratio of 1.286 (95  % CI 1.099-1.504) by every 300 points increase. AVCS was also a strong predictor for severe @entity6 with area under the curve 0.855 with a cutoff value of 897 (sensitivity 86.7  %, specificity 72.2  %). Conclusively, aortic @entity5 score calculated by quantitative CT is a reliable marker in evaluating severity of @entity6 .

title: The significance of aortic valve calcification in XXXX with @entity7 .

answer: @entity0


abstract: The FETAX (Frog Embryo Teratogenesis Assay-- @entity5 ) whole embryo bioassay has been developed to screen for environmental substances that cause @entity4 . We have used this assay to test its effectiveness in working with actual water samples from the field. Tar Creek is contaminated by discharges from abandoned lead and @entity3 mines. In addition to high concentrations of @entity3 , @entity1 and other metals, water samples are routinely low in pH and @entity0 content. The pH values of three Tar Creek sample sites were below the established tolerance limits of the embryos. Therefore, one group of samples had no pH adjustment while a second group had the pH adjusted to 7.0. Two of the four sites contained agents that reduced embryonic growth and caused high rates of mortality. A third site contained teratogenic substances. We have determined that metal content is responsible, along with the low pH, for the biologic effects. We have identified high concentrations of toxic metals in Tar Creek by water analysis and were able to demonstrate, by removing metals via Chelex 100 ion exchange chromatography, that the observed @entity2 and teratogenicity were caused by metal ions. We have concluded that FETAX is an excellent test for complex mixtures. Physicochemical parameters, such as pH, @entity0 and metals content, can be altered and the effect of these changes on @entity2 and teratogenicity determined using FETAX. The interaction of toxic substances and low pH are important when considering embryo survival and development.

title: Detection of teratogenic substances in acidic mine water samples using the frog embryo teratogenesis assay-- XXXX (FETAX).

answer: @entity5


abstract: Purpose: HM781-36B is a novel and irreversible pan- @entity0 @entity2 (HER) inhibitor with TEC cytoplasmic kinase inhibition. The aim of this study is to evaluate the antitumor activity and mechanism of action for HM781-36B in @entity1 cell lines. Materials and Methods: The @entity1 cell lines were exposed to HM781-36B and/or oxaliplatin (L-OHP), 5-fluorouracil (5-FU), SN-38. The cell viability was examined by Cell Titer-Glo luminescent cell viability assay kit. Change in the cell cycle and protein expression was determined by flow cytometry and immunoblot analysis, respectively. Synergism between 2 drugs was evaluated by the combination index. Results: The addition of HM781-36B induced potent growth inhibition in both DiFi cells with @entity2 overexpression and SNU-175 cells (IC50 = 0.003 and 0.005    M, respectively). Furthermore, HM781-36B induced G1 arrest of the cell cycle and apoptosis, and reduced the levels of HER family and downstream signaling molecules, @entity4 and pAKT, as well as nonreceptor/cytoplasmic tyrosine kinase, @entity5 . The combination of HM781-36B with 5-FU, L-OHP, or SN-38 showed an additive or synergistic effect in most @entity1 cells. Conclusion: These findings suggest the potential roles of HM781-36B as the treatment for @entity2 -overexpressing @entity3 , singly or in combination with chemotherapeutic agents. The role of @entity5 expression as a marker of response to HM781-36B should be further explored.

title: Antitumor Activity of HM781-36B, alone or in Combination with Chemotherapeutic Agents, in XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity0 oocyte undergos two asymmetric cell divisions during meiotic maturation and fertilization. Acentric spindle positioning and cortical polarity are major factors involved in asymmetric cell division, both of which are thought to depend on the dynamic interaction between myosin II and actin filaments. @entity3 ( @entity3 ) encoding by Mylk1 gene could directly phosphorylate and activate myosin II. To determine whether @entity3 was required for oocyte asymmetric division, we specifically disrupted Mylk1 gene in oocytes by Cre-loxP conditional knockout system. We found that Mylk1 mutant female @entity1 showed severe @entity2 . Unexpectedly, contrary to previously reported in vitro findings, our data showed that oocyte meiotic maturation including spindle organization, polarity establishment, homologous chromosomes separation and polar body extrusion were not affected in Mylk1(fl/fl);GCre(+) females. Follicular development, ovulation and early embryonic develop to compact morula occurred normally in Mylk1(fl/fl);GCre(+) females, but deletion of @entity3 caused delayed morula-to-blastocyst transition. More than a third of embryos were at morula stage at 3.5 days post coitum (dpc) in vivo. The delayed embryos could develop further to early blastocyst stage in vitro on Day 4 when most control embryos reached expanded blastocysts. Our findings provide evidence that @entity3 is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation.

title: Deletion of Mylk1 in Oocytes Causes Delayed Morula-to-Blastocyst Transition and Reduced Fertility Without Affecting Folliculogenesis and Oocyte Maturation in XXXX .

answer: @entity1


abstract: OBJECTIVE: The primary aim was to assess the psychological factors that influence engagement in health behaviors in individuals with @entity2 using a new measure, the Behavioral Engagement Test for @entity2 (BET-CP). A secondary aim was to determine preliminary psychometric properties of the BET-CP. SUBJECTS: @entity0 were 86 adults with chronic @entity4 recruited from University of @entity1 clinics and the community. METHODS: @entity0 completed a battery of self-report instruments online, including the BET-CP and measures of related constructs. Items on the BET-CP assessed motivation, self-efficacy, outcome expectations, and the symptom benefit required to engage across four health behaviors: exercise, diet, sleep, and @entity1 self-management (e.g., relaxation and activity pacing). RESULTS: @entity0 reported modest expectations of @entity1 -related symptom improvement if they practiced the health behaviors (22-26% improvement), but they required twice that (47-54% improvement) to make it worth their while to commit to practicing them. @entity0 expected to get the most symptom relief from relaxation and activity pacing, but they were most confident and motivated to eat a healthy diet. In a subsample of @entity0 who provided data for psychometric analysis, the BET-CP demonstrated strong test-retest reliability across 7 days and adequate convergent validity. CONCLUSION: While @entity0 with @entity4 have outcome expectancies that are nearly in line with research on @entity1 treatments, their stringent requirements for symptom benefit may impede engagement in the health behaviors recommended for their @entity3 . Additional psychometric study with larger sample sizes is needed to further validate the BET-CP.

title: Cognitive-Motivational Influences on Health Behavior Change in Adults with XXXX .

answer: @entity2


abstract: OBJECTIVE: To examine associations between food insecurity, excess body weight, psychosocial factors and food behaviours among low-income African-American families. DESIGN: Cross-sectional survey of @entity0 in the baseline evaluation of the B'More Healthy Communities for Kids (BHCK) @entity1 prevention trial. We collected data on socio-economic factors, food source destinations, acquiring food, preparation methods, psychosocial factors, beliefs and attitudes, participation in food assistance programmes, anthropometry and food security. We used principal component analysis to identify patterns of food source destinations and logistic regression to examine associations. SETTING: Fourteen low-income, predominantly African-American neighbourhoods in Baltimore City, @entity2 , USA. SUBJECTS: Two hundred and ninety-eight adult caregiver- @entity0 (10-14 years old) dyads. RESULTS: Of households, 41  6 % had some level of food insecurity and 12  4 % experienced some level of hunger. Food-insecure @entity0 with hunger were significantly more likely to be unemployed and to have lower incomes. We found high rates of excess body weight ( @entity3 and @entity1 ) among adults and @entity0 (82  8 % and 37  9 % among food insecure without hunger, 89  2 % and 45  9 % among food insecure with hunger, respectively), although there were no significant differences by food security status. Food source usage patterns, food acquisition, preparation, knowledge, self-efficacy and intentions did not differ by food security. Food security was associated with perceptions that healthy foods are affordable and convenient. Greater caregiver body satisfaction was associated with food insecurity and excess body weight. CONCLUSIONS: In this setting, @entity1 and food insecurity are major problems. For many food-insecure families, perceptions of healthy foods may serve as additional barriers to their purchase and consumption.

title: Food insecurity, @entity3 and XXXX among low-income African-American families in Baltimore City: associations with food-related perceptions.

answer: @entity1


abstract: OBJECTIVE: To examine associations between food insecurity, excess body weight, psychosocial factors and food behaviours among low-income African-American families. DESIGN: Cross-sectional survey of @entity0 in the baseline evaluation of the B'More Healthy Communities for Kids (BHCK) @entity1 prevention trial. We collected data on socio-economic factors, food source destinations, acquiring food, preparation methods, psychosocial factors, beliefs and attitudes, participation in food assistance programmes, anthropometry and food security. We used principal component analysis to identify patterns of food source destinations and logistic regression to examine associations. SETTING: Fourteen low-income, predominantly African-American neighbourhoods in Baltimore City, @entity2 , USA. SUBJECTS: Two hundred and ninety-eight adult caregiver- @entity0 (10-14 years old) dyads. RESULTS: Of households, 41  6 % had some level of food insecurity and 12  4 % experienced some level of hunger. Food-insecure @entity0 with hunger were significantly more likely to be unemployed and to have lower incomes. We found high rates of excess body weight ( @entity3 and @entity1 ) among adults and @entity0 (82  8 % and 37  9 % among food insecure without hunger, 89  2 % and 45  9 % among food insecure with hunger, respectively), although there were no significant differences by food security status. Food source usage patterns, food acquisition, preparation, knowledge, self-efficacy and intentions did not differ by food security. Food security was associated with perceptions that healthy foods are affordable and convenient. Greater caregiver body satisfaction was associated with food insecurity and excess body weight. CONCLUSIONS: In this setting, @entity1 and food insecurity are major problems. For many food-insecure families, perceptions of healthy foods may serve as additional barriers to their purchase and consumption.

title: Food insecurity, XXXX and @entity1 among low-income African-American families in Baltimore City: associations with food-related perceptions.

answer: @entity3


abstract: Pericentric inversion of @entity0 chromosome 9 [inv(9)] is a relatively common cytogenetic finding. It is largely considered a clinically insignificant variant of the normal @entity0 karyotype. However, numerous studies have suggested its possible association with certain pathologies, e.g., @entity3 , @entity4 or @entity1 . We analysed the incidence of inv(9) and the spectrum of clinical indications for karyotyping among inv(9) carriers in three medical genetics departments in Prague. In their cytogenetic databases, among 26,597 total records we identified 421 (1.6 %) cases of inv(9) without any concurrent cytogenetic pathology. This study represents the world's largest epidemiological study on inv(9) to date. The incidence of inv(9) calculated in this way from diagnostic laboratory data does not differ from the incidence of inv(9) in three specific populationbased samples of healthy individuals (N = 4,166) karyotyped for preventive (amniocentesis for advanced maternal age, gamete donation) or legal reasons ( @entity0 awaiting adoption). The most frequent clinical indication in inv(9) carriers was " @entity2 " - 37.1 %. The spectra and percentages of indications in individuals with inv(9) were further statistically evaluated for one of the departments (N = 170) by comparing individuals with inv(9) to a control group of 661 individuals with normal karyotypes without this inversion. The proportion of clinical referrals for " @entity2 " among inv(9) cases remains higher than in controls, but the difference is not statistically significant for both genders combined. Analysis in separated genders showed that the incidence of " @entity2 " could differ among inv(9) female and male carriers.

title: Pericentric Inversion of XXXX Chromosome 9 Epidemiology Study in Czech Males and Females.

answer: @entity0


abstract: UNASSIGNED: Conventional cytostatic @entity0 treatments rarely result in the complete eradication of @entity0 cells. Therefore, new therapeutic strategies focus on antagonizing the immunosuppressive activity of established @entity0 . In particular, recent studies of antigen-loaded dendritic cells (DCs) eliciting a specific antitumor immune response has raised the hopes of achieving the complete elimination of @entity0 tissue. @entity5 , fingolimod and betulin have already been described as active compounds in different types of @entity0 . Herein, we applied an integrated screening approach to characterize both their cytostatic and their immune-modulating properties side-by-side. As will be described in detail, our data confirmed that all three compounds exerted proapoptotic and antiproliferative activity in different @entity8 cell lines to a given extent, as revealed by an @entity2 assay, CFSE and @entity10 staining. However, while @entity5 and fingolimod also affected the survival of primary bone marrow (BM) derived DCs of C57BL/6 @entity1 , betulin exhibited a lower @entity3 for BMDCs in comparison to the @entity4 cells. Moreover, we could show for the first time, that only betulin caused a simultaneous, highly specific immune-stimulating activity, as measured by the IL-12p70 release of @entity6 -stimulated BMDCs by ELISA, which was due to increased @entity9 mRNA expression. Interestingly, the activation of DCs resulted in enhanced T lymphocyte stimulation, indicated by increased @entity7 and IFN-y production of cytotoxic T cells in spleen cell co-culture assays which led to a decreased viability of B16 cells in an antigen specific model system. This may overcome the immunosuppressive environment of a @entity0 and destroy @entity0 cells more effectively in vivo if the immune response is specific targeted against the @entity0 tissue by antigen-loaded dendritic cells. In summary, cytostatic agents, such as betulin, that simultaneously exhibit immune stimulatory activity may serve as lead compounds and hold great promise as a novel approach for an integrated @entity0 therapy.

title: Simultaneous and Dose XXXX Cytotoxic and Immune Stimulatory Activity of Betulin.

answer: @entity4


abstract: BACKGROUND: To analyze the costs of inhospital, percutaneous treatment of @entity0 with @entity1 ( @entity1 ) carried out in Poland, a European Union country with a low-budget national health system. METHODS: A retrospective analysis of prospectively collected data on all @entity0 admitted to a tertiary care hospital for endovascular treatment of @entity1 over 1 year. SETTING: A single, large volume, tertiary angiology center located in Southern Poland. @entity0 : @entity1 @entity0 due to aortoiliac, femoropopliteal, or infrapopliteal arterial stenoses or occlusions with indications for first-line endovascular therapy or similar @entity0 who refused open surgical procedure despite having primary indications for vascular surgery. INTERVENTIONS: Direct stenting using bare-metal stents was the primary mode of treatment for lesions located within the aortoiliac and femoropopliteal arterial segments. Plain old balloon angioplasty (POBA) was the second most commonly used technique. For below-the-knee arteries, POBA was the mainstay of treatment, which was occasionally supported by drug-eluting stent angioplasty. Directional atherectomy, scoring balloon angioplasty, or local fibrinolysis was used infrequently. Drug-eluting balloon percutaneous transluminal angioplasty was not used. MAIN OUTCOME MEASURES: The main outcome measures were the mean reimbursement of costs provided by the Polish National Health Fund (NHF) for inhospital treatment of @entity0 for whom endovascular procedures were performed as initial treatment for @entity1 and the inhospital costs of endovascular treatment calculated by the caregiver in the 2 years since the first procedure. The average total number of days spent in hospital, amputation-free survival (AFS), @entity2 ( @entity2 ), and limb salvage rate (LSR) according to a life-table method were also calculated for the 2 years. RESULTS: In the first year, there were 496 endovascular and 15 surgical hospitalizations for revascularization procedures to treat 340 limbs in 327 @entity0 , with a further 53 revascularization procedures in the second year. There were an additional 90 hospitalizations over the first year and 38 over the second year for @entity1 -associated cardiovascular comorbidities. The mean reimbursement for hospitalizations of @entity0 included into observation, provided by the NHF, was  4901.94 per @entity0 for the first year and  833.57 per @entity0 alive to the second year. The mean cost of hospitalization for percutaneous revascularization treatment was  3804.25 per @entity0 for the first year and  3340.30 per @entity0 requiring revascularization within the second year. All costs were calculated in constant 2011 USD. The average total number of days spent in hospital was 8.4  days for the first year and 1.97  days per @entity0 alive to the second year. At 1 and 2  years, the AFS was 76.8% and 66.6%, the @entity2 was 86.5% and 77.3%, and the LSR was 89.4% and 86%, respectively. CONCLUSIONS: Endovascular therapy using the currently available techniques can be performed in almost all @entity0 suffering from @entity1 at relatively low costs, and satisfactory results can be obtained. Physicians play a pivotal role in ensuring quality of treatment and the reduction of treatment cost in these @entity0 .

title: Costs of Real-Life Endovascular Treatment of XXXX : Report from Poland-A European Union Country with a Low-Budget Health Care System.

answer: @entity1


abstract: OBJECTIVE: To investigate the development of nephrotoxicity associated with @entity4 dose, and whether this relationship differs depending on renal function. DESIGN: A retrospective cohort study of @entity0 who received intravenous @entity4 to treat @entity1 caused by extensively drug-resistant Gram-negative microorganisms. Adult @entity0 receiving @entity4 for 72 hours or longer were included in this study. @entity0 who received renal replacement therapy at baseline or were administered @entity4 for less than 3 days were excluded. @entity4 -induced nephrotoxicity was defined as a doubling of baseline serum @entity3 . @entity4 dosing was evaluated based on both actual body weight and ideal body weight. SETTING: Single general hospital between 2010 and 2013. @entity0 : A total number of 475 @entity0 received @entity4 therapy. Of these @entity0 , 329 met the inclusion criteria and were included in the analysis. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: One hundred forty-three @entity0 (43.5%) experienced nephrotoxicity during @entity4 treatment. The median onset time of nephrotoxicity was 6 days (interquartile range, 4-8 days). The @entity0 with nephrotoxicity were older. Hematocrit and serum albumin levels were lower in @entity0 with nephrotoxicity. Median daily dosing of @entity4 based on ideal body weight was significantly higher in @entity0 with nephrotoxicity than in those without nephrotoxicity (4.55 vs 4.43 mg/kg/d, respectively; p = 0.021). The cumulative dose was not different between @entity0 with and without nephrotoxicity. In multiple logistic regression analysis, daily @entity4 dosing based on ideal body weight was only significantly associated with the development of nephrotoxicity in @entity0 with an estimated glomerular filtration rate < 60 mL/ @entity2 .73 m (odds ratio, 2.34; 95% CI, 1.22-4.5). In these affected @entity0 , based on a receiver operating characteristic plot, the optimal predictive cutoff of @entity4 dose for the development of nephrotoxicity was 2.87 mg/kg/d of @entity4 , with a sensitivity of 92.3% and a specificity of 76.7%. In @entity0 with estimated glomerular filtration rate >=  60 mL/ @entity2 .73 m, age, serum albumin, hematocrit, and use of glycopeptide were associated with the development of nephrotoxicity. CONCLUSIONS: Development of nephrotoxicity was significantly more strongly associated with the dose of @entity4 , but only in @entity0 with an estimated glomerular filtration rate < 60 mL/ @entity2 .73 m and not in those with normal renal function.

title: Association Between XXXX Dose and Development of Nephrotoxicity.

answer: @entity4


abstract: BACKGROUND: Epidemiological and clinical studies have clearly established the link between low-density lipoprotein @entity4 ( @entity11 ) and @entity7 -related cardiovascular consequences. Although it has been a common practice for physicians to prescribe lipid-lowering therapy for @entity0 with @entity9 , the achievement rate is still not satisfied in Taiwan. Therefore, the determinants for achieving the @entity11 target needed to be clarified for better healthcare of the @entity0 with @entity9 . METHOD: This registry-type prospective observational study enrolled the @entity0 with @entity2 ( @entity6 ( @entity6 ) and @entity3 ( @entity3 )) from 18 medical centers across Taiwan, and clinically followed them for five years. At every clinical visit, vital signs, clinical endpoints, adverse events, concurrent medications and laboratory specimens were obtained as thoroughly as possible. The lipid profile (total @entity4 , high-density lipoprotein @entity4 , @entity11 , @entity5 ), liver enzymes, and @entity8 phosphokinase were evaluated at baseline, and every year thereafter. The cross sectional observational data was analyzed for this report. RESULT: Among the 3,486 registered @entity0 , 54% had their @entity11 < 100 mg/dL. By univariate analysis, the @entity0 achieving the @entity11 target were associated with older age, more male sex, taller height, lower blood pressure, more under lipid-lowering therapy, more smoking cessation, more history of @entity6 , @entity10 , physical activity, but less history of @entity3 . The multivariate analysis showed statin therapy was the most significant independent determinant for achieving the treatment target, followed by age, history of @entity6 , @entity1 , blood pressure, and sex. However, most @entity0 were on regimens of very-low to low equipotent doses of statins. CONCLUSION: Although the lipid treatment guideline adherence is improving in recent years, only 54% of the @entity0 with @entity2 have achieved their @entity11 target in Taiwan, and the most significant determinant for this was statin therapy.

title: Determinants for Achieving the XXXX Target of Lipid Control for Secondary Prevention of Cardiovascular Events in Taiwan.

answer: @entity11


abstract: AIM: Dietary restriction (DR) and @entity3 ( @entity3 ) induce robust protection against the detrimental effects of @entity0 (I/RI). Several mechanisms of protection have been proposed, such as hormesis. Hormesis is defined as a life-supporting beneficial effect resulting from the cellular responses to single or multiple rounds of (mild) stress. The cold exposure (CE) model is a stress model similar to DR, and has been shown to have hormetic effects and has proved to increase longevity. CE is considered to be the most robust method to increase metabolism through activation of brown adipocytes. BAT has been considered important in etiology of @entity2 and its metabolic consequences. MATERIALS AND METHODS: Since DR, @entity3 , and CE models are proposed to work through hormesis, we investigated physiology of adipose tissue and effect on BAT in these models and compared them to ad libitum (AL) fed @entity1 . We also studied the differential effect of these stress models on immunological changes, and effect of CE on renal I/RI. KEY FINDINGS: We show similar physiological changes in adiposity in male C57Bl/6 @entity1 due to DR, @entity3 and CE, but the CE @entity1 were not protected against renal I/RI. The immunophenotypic changes observed in the CE @entity1 were similar to the AL animals, in contrast to @entity3 @entity1 , that showed major immunophenotypic changes in the B and T cell development stages in primary and secondary lymphoid organs. SIGNIFICANCE: Our findings thus demonstrate that DR, @entity3 and CE are hormetic stress models. DR and @entity3 protect against renal I/IR, whereas CE could not.

title: Protection against XXXX through hormesis? Dietary intervention versus cold exposure.

answer: @entity0


abstract: AIM: Echocardiographic screening for @entity2 has been piloted in high-risk areas in New Zealand and internationally, and fulfils most of the criteria for a targeted screening programme. The question of acceptability of @entity2 screening has not been assessed, and the aim of our study was to assess parental acceptability of a school-based echocardiographic screening programme in a high-risk population in New Zealand. METHODS: A post-screening questionnaire was developed to survey parents of @entity0 who underwent echocardiographic screening. The families of 34 @entity0 with abnormal scan results and a sample of 80 @entity0 with normal scan results were surveyed by phone within 4 months of screening. RESULTS: Positive results were seen in all survey questions in both normal and abnormal scan groups. All families were supportive of an ongoing screening programme. Of @entity0 with abnormal results, 62% of their parents reported that they would treat their @entity0 differently; however, all responses were positive health-promoting outcomes. CONCLUSION: The study showed strong positive support for school-based echocardiographic screening by a community with high @entity1 incidence. The study did not detect any short-term negative effects in those with abnormal results. The survey result shows family and community support for the establishment of echocardiographic screening programmes in high @entity1 areas provided there is adequate infrastructural support.

title: Family acceptability of school-based echocardiographic screening for XXXX in a high-risk population in New Zealand.

answer: @entity2


abstract: UNASSIGNED: @entity3 + T cells ( @entity4 + Tregs and @entity5 + Treg) have been demonstrated to play roles in the maintenance of tolerance after allogeneic hematopoietic stem cell transplantation (Allo-HSCT). We have found that @entity3 + y  TCR+ Treg cells (y  Tregs) exerted regulatory functions. In the current study, @entity0 were recruited and divided as non-cGVHD, limited cGVHD and extensive cGVHD groups. Healthy volunteers were recruited as healthy group. Treg cells were evaluated by flow cytometry. Serum cytokine levels of @entity6 , @entity1 @entity2 factor-a, interferon-y and transforming growth factor-b1 ( @entity7 ) were evaluated by ELISA. The results showed that percentages of @entity4 + Tregs, @entity5 + Tregs and y  Tregs were all significantly increased in non-cGVHD group compared with those in healthy group, limited cGVHD group and extensive cGVHD group. Moreover, compared with extensive cGVHD group, percentages of these three types of Tregs were significantly increased in limited cGVHD group. The levels of @entity7 increased dramatically in non-cGVHD group compared with other groups. Spearman's correlation analysis revealed that the increased levels of @entity7 and @entity6 were positively associated with increased Treg subsets, indicating that @entity7 and @entity6 participated in the expansion process of @entity3 + Tregs in vivo. Our findings support that increasing the number of Tregs following allo-HSCT would be a preferential strategy for controlling cGVHD. Copyright    2015 John Wiley _ Sons, Ltd.

title: Reduction of XXXX + T cell subsets involved in incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

answer: @entity3


abstract: @entity3 are essential for embryonic and fetal survival, growth, and development. Additionally, @entity3 may induce autophagy in @entity0 cells. However, little is known about the availability of @entity3 or autophagy in the porcine conceptus with @entity1 ( @entity1 ). The present study was performed to evaluate the developmental changes of @entity4 concentrations in @entity1 and normal porcine fetuses as well as autophagic marker levels in the fetal intestinal mucosa during the second half of gestation when most fetal growth occurs. @entity5 ( @entity5 ), amniotic fluid (AMF), umbilical vein, and the small-intestinal mucosa were obtained from both @entity1 and normal fetal @entity2 at d 60, 90, and 110 of gestation. Concentrations of @entity3 in fetal fluids as well as protein abundances of microtubule-associated protein light chain 3B (LC3B), an autophagic marker, in the fetal small-intestinal mucosa were determined. Concentrations of @entity3 varied greatly in different fetal compartments and changed substantially with advancing gestation. Concentrations of @entity3 in @entity1 fetal fluids and the small-intestinal mucosa were markedly different from those in their normal counterparts at d 60 and 90 of gestation, whereas most of the differences were not detected by late (d 110) gestation. Specifically, @entity4 levels were lower in the umbilical vein plasma but higher in @entity5 and AMF from @entity1 fetuses. Furthermore, enhanced levels of an autophagic marker were observed in the small-intestinal mucosa of @entity1 fetuses throughout mid and late gestation in association with abnormal @entity6 levels in fetal plasma. These findings support the notion that enhanced autophagy may be an important survival mechanism in @entity1 fetuses. Collectively, our findings provide a new framework for future studies to define the roles for @entity3 in the prevention and treatment of @entity1 in both @entity0 medicine and animal production.

title: Developmental changes in XXXX and autophagic marker levels in normal and growth-restricted fetal @entity2 .

answer: @entity3


abstract: @entity3 are essential for embryonic and fetal survival, growth, and development. Additionally, @entity3 may induce autophagy in @entity0 cells. However, little is known about the availability of @entity3 or autophagy in the porcine conceptus with @entity1 ( @entity1 ). The present study was performed to evaluate the developmental changes of @entity4 concentrations in @entity1 and normal porcine fetuses as well as autophagic marker levels in the fetal intestinal mucosa during the second half of gestation when most fetal growth occurs. @entity5 ( @entity5 ), amniotic fluid (AMF), umbilical vein, and the small-intestinal mucosa were obtained from both @entity1 and normal fetal @entity2 at d 60, 90, and 110 of gestation. Concentrations of @entity3 in fetal fluids as well as protein abundances of microtubule-associated protein light chain 3B (LC3B), an autophagic marker, in the fetal small-intestinal mucosa were determined. Concentrations of @entity3 varied greatly in different fetal compartments and changed substantially with advancing gestation. Concentrations of @entity3 in @entity1 fetal fluids and the small-intestinal mucosa were markedly different from those in their normal counterparts at d 60 and 90 of gestation, whereas most of the differences were not detected by late (d 110) gestation. Specifically, @entity4 levels were lower in the umbilical vein plasma but higher in @entity5 and AMF from @entity1 fetuses. Furthermore, enhanced levels of an autophagic marker were observed in the small-intestinal mucosa of @entity1 fetuses throughout mid and late gestation in association with abnormal @entity6 levels in fetal plasma. These findings support the notion that enhanced autophagy may be an important survival mechanism in @entity1 fetuses. Collectively, our findings provide a new framework for future studies to define the roles for @entity3 in the prevention and treatment of @entity1 in both @entity0 medicine and animal production.

title: Developmental changes in @entity3 and autophagic marker levels in normal and growth-restricted fetal XXXX .

answer: @entity2


abstract: Forty-eight individually fed crossbred steers (initial BW = 381    7.61 kg) were used to determine the effects of @entity0 ( @entity2 ) concentration in steam-flaked @entity3 (SFC)-based diets with added yellow grease on animal performance and carcass characteristics. @entity0 was included at 0, 2.5, 5, and 10% dietary @entity1 replacing SFC. A completely randomized design was used with steers as the experimental unit, and the model included the fixed effects of diet. Contrast statements were used to determine linear and quadratic effects of @entity2 inclusion. Final BW and DMI were not affected ( > 0.27) by @entity2 concentration. Average daily gain and G:F based on live BW did not differ as @entity2 level increased in the diet from 0 to 10% of @entity1 ( > 0.33). Carcass-adjusted final BW and carcass-adjusted G:F were also not affected by @entity2 concentration ( > 0.22); however, carcass-adjusted ADG tended to respond quadratically by decreasing from 2.5 to 5% @entity2 inclusion and increasing thereafter ( = 0.10). Calculated dietary NE and NE did not differ as @entity2 increased in the diet ( > 0.37). Hot carcass weight tended to respond quadratically, decreasing from 2.5 to 5% @entity2 and increasing thereafter ( = 0.10). Likewise, dressing percentage tended to respond quadratically by decreasing from 2.5 to 5% @entity2 inclusion and increasing to 10% @entity2 inclusion ( = 0.09). Fat thickness decreased linearly as @entity2 inclusion increased in the diet ( < 0.01); however, no differences were detected in marbling score and LM area ( > 0.21). Calculated yield grade (YG) decreased linearly as @entity2 increased in the diet from 0 to 10% of @entity1 ( = 0.04). Based on our results, there was no animal performance benefit for replacing SFC with @entity2 in diets containing yellow grease, and the only change in carcass merit was a slight improvement in YG.

title: Effects of @entity0 concentration in steam-flaked XXXX -based diets with supplemental yellow grease on performance and carcass characteristics of finishing beef steers.

answer: @entity3


abstract: Forty-eight individually fed crossbred steers (initial BW = 381    7.61 kg) were used to determine the effects of @entity0 ( @entity2 ) concentration in steam-flaked @entity3 (SFC)-based diets with added yellow grease on animal performance and carcass characteristics. @entity0 was included at 0, 2.5, 5, and 10% dietary @entity1 replacing SFC. A completely randomized design was used with steers as the experimental unit, and the model included the fixed effects of diet. Contrast statements were used to determine linear and quadratic effects of @entity2 inclusion. Final BW and DMI were not affected ( > 0.27) by @entity2 concentration. Average daily gain and G:F based on live BW did not differ as @entity2 level increased in the diet from 0 to 10% of @entity1 ( > 0.33). Carcass-adjusted final BW and carcass-adjusted G:F were also not affected by @entity2 concentration ( > 0.22); however, carcass-adjusted ADG tended to respond quadratically by decreasing from 2.5 to 5% @entity2 inclusion and increasing thereafter ( = 0.10). Calculated dietary NE and NE did not differ as @entity2 increased in the diet ( > 0.37). Hot carcass weight tended to respond quadratically, decreasing from 2.5 to 5% @entity2 and increasing thereafter ( = 0.10). Likewise, dressing percentage tended to respond quadratically by decreasing from 2.5 to 5% @entity2 inclusion and increasing to 10% @entity2 inclusion ( = 0.09). Fat thickness decreased linearly as @entity2 inclusion increased in the diet ( < 0.01); however, no differences were detected in marbling score and LM area ( > 0.21). Calculated yield grade (YG) decreased linearly as @entity2 increased in the diet from 0 to 10% of @entity1 ( = 0.04). Based on our results, there was no animal performance benefit for replacing SFC with @entity2 in diets containing yellow grease, and the only change in carcass merit was a slight improvement in YG.

title: Effects of XXXX concentration in steam-flaked @entity3 -based diets with supplemental yellow grease on performance and carcass characteristics of finishing beef steers.

answer: @entity0


abstract: In @entity2 immune complexes in inflamed vessel walls characteristically contain immunoglobulin A(IgA). To determine whether IgA is also the predominant immunoglobulin in circulating immune complexes, we compared the results of three immune complex assays with specificities for different classes of immunoglobulins in a longitudinal study of 37 @entity0 (30 @entity0 and seven adults) with @entity2 . Circulating IgA-containing immune complexes were detected by their reactivity with a low avidity anti-IgA antibody in 27 of the 37 @entity0 . IgA was simultaneously present in cutaneous vessel walls in 95 percent of the @entity0 with circulating IgA-containing immune complexes. High levels of IgA-containing immune complexes were found only during the initial phase of the disease. Immune complexes containing bound complement breakdown products were demonstrated by binding to conglutinin. IgA was found in these immune complexes in 17 patients, IgG in 17 and IgM in nine @entity0 . There was no apparent relation with the class of immunoglobulin in the deposits. Conglutinin-binding immune complexes were present later in the course of the disease and after remission. @entity3 -binding immune complexes were only found in two @entity0 . These findings suggest that immune complexes-containing IgA may initiate the @entity1 of @entity2 , whereas complement-reacted immune complexes containing immunoglobulins of the other classes appear in the circulation in a later phase.

title: Circulating IgA-immune complexes in XXXX . A longitudinal study of their relationship to disease activity and vascular deposition of IgA.

answer: @entity2


abstract: OBJECTIVE: To explore the effective treatment of sudden @entity4 and factors affecting its prognosis. METHOD: The clinical data and follow-up results of 164 @entity0 with sudden @entity4 were analyzed retrospectively. All the 164 @entity0 were given intravenous vasodilator, neurotrophic drugs treatment, oral @entity1 treatment, and intratympanic @entity3 injection. All @entity0 were divided into low frequency @entity2 type,intermediate frequency @entity2 , high frequency @entity2 , all frequency @entity2 and @entity5 group. Pure tone hearing threshold test were performed before and 3 months after treatment. All @entity0 and different groups were compared before and after treatment damage frequency of average air conduction and various frequency air conduction hearing. Analysis of gender, age, process and hearing curve type, frequency hearing of impaired before treatment, the symptoms with or without vertigo. RESULT: All the @entity0 ' hearing improved after treatment. The treatment efficiency was 46.3%, and low frequency hearing improvements were better than the high frequency hearing. Including age, process, frequency hearing of impaired before treatment, with or without vertigo isindependent factors influencing its prognosis. CONCLUSION: Based on the regular treatment,oral and intratympanic injection glucocorticoid therapy are safe and effective for sudden @entity2 ,The prognosis and age, course, impaired hearing before curve type, treatment frequency hearing level is closely related, with or without vertigo.

title: [The treatment effects analysis of 164 @entity0 with sudden XXXX ].

answer: @entity4


abstract: OBJECTIVE: To explore the effective treatment of sudden @entity4 and factors affecting its prognosis. METHOD: The clinical data and follow-up results of 164 @entity0 with sudden @entity4 were analyzed retrospectively. All the 164 @entity0 were given intravenous vasodilator, neurotrophic drugs treatment, oral @entity1 treatment, and intratympanic @entity3 injection. All @entity0 were divided into low frequency @entity2 type,intermediate frequency @entity2 , high frequency @entity2 , all frequency @entity2 and @entity5 group. Pure tone hearing threshold test were performed before and 3 months after treatment. All @entity0 and different groups were compared before and after treatment damage frequency of average air conduction and various frequency air conduction hearing. Analysis of gender, age, process and hearing curve type, frequency hearing of impaired before treatment, the symptoms with or without vertigo. RESULT: All the @entity0 ' hearing improved after treatment. The treatment efficiency was 46.3%, and low frequency hearing improvements were better than the high frequency hearing. Including age, process, frequency hearing of impaired before treatment, with or without vertigo isindependent factors influencing its prognosis. CONCLUSION: Based on the regular treatment,oral and intratympanic injection glucocorticoid therapy are safe and effective for sudden @entity2 ,The prognosis and age, course, impaired hearing before curve type, treatment frequency hearing level is closely related, with or without vertigo.

title: [The treatment effects analysis of 164 XXXX with sudden @entity4 ].

answer: @entity0


abstract: INTRODUCTION: Exertional-induced bronchoconstriction is a condition in which the physical activity causes constriction of airways in @entity0 with airway hyper- responsiveness. In this study, we tried to study and evaluate any relationship between the findings of cardiopulmonary exercise testing (CPET) and the response to @entity7 challenge test (MCT) in @entity0 with @entity5 after activity. MATERIALS AND METHODS: Thirty @entity0 with complaints of @entity5 following activity referred to "Lung Clinic" of Baqiyatallah Hospital but not suffering from @entity4 were entered into the study. The subjects were excluded from the study if: Suffering from any other @entity3 , smoking more than 1 cigarette a week in the last year, having a history of smoking more than 10 packets of cigarettes/year, having @entity6 in the past 4 weeks, having abnormal chest X-ray or electrocardiogram, and cannot discontinue the use of medicines interfering with bronchial provocation. Baseline spirometry was performed for all the @entity0 , and the values of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV/FVC were recorded. The MCT and then the CPET were performed on all @entity0 . RESULTS: The mean VO 2 (volume @entity1 ) in @entity0 with positive @entity7 test (20.45 mL/kg/min) was significantly lower than @entity0 with negative MCT (28.69 mL/kg/min) (P = 0.000). Respiratory rates per minute (RR) and minute ventilation in the group with positive MCT (38.85 and 1.636 L) were significantly lower than the group with negative @entity7 test (46.78 and 2.114 L) (P < 0.05). Also, the O 2 pulse rate in the group with negative @entity7 test (116.27 mL/beat) was significantly higher than the group with positive @entity7 test (84.26 mL/beat) (P < 0.001). CONCLUSION: Pulmonary response to exercise in @entity0 with positive @entity7 test is insufficient. The dead space ventilation in these @entity0 has increased. Also, dynamic hyperinflation in @entity0 with positive @entity7 test causes the reduced @entity2 volume and O 2 pulse in these @entity0 .

title: Exertional-induced bronchoconstriction: Comparison between cardiopulmonary exercise test and XXXX challenging test.

answer: @entity7


abstract: OBJECTIVES: Elevated low-density lipoprotein @entity1 and @entity5 are major risk factors for @entity3 . However, @entity6 from @entity5 are a major energy source, low-density lipoprotein @entity1 is critical for cell membrane synthesis, and both are critical for cell survival. This study was designed to clarify the relationship between lipid profile, morbidity as assessed by Killip classification, and 30-day mortality in @entity0 with @entity4 . DESIGN: A noninterventional observational study. SETTING: Coronary care unit in a university hospital. @entity0 : Seven hundred twenty-four @entity0 with @entity4 in the coronary care program of the Bureau of Health Promotion were analyzed. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Low-density lipoprotein @entity1 and @entity2 levels were significantly lower in high-Killip (III+IV) @entity0 compared with low-Killip (I+II) @entity0 and in those who died compared with those who survived beyond 30 days (both p<0.001). After adjustment for risk factors, low-density lipoprotein @entity1 less than 62.5 mg/dL and @entity5 less than 110 mg/dL were identified as optimal threshold values for predicting 30-day mortality and were associated with hazard ratios of 1.65 (95% CI, 1.18-2.30) and 5.05 (95% CI, 1.75-14.54), and the actual mortality rates were 23% in low low-density lipoprotein, 6% in high low-density lipoprotein, 14% in low @entity5 , and 3% in high @entity5 groups, respectively. To test the synergistic effect, high-Killip @entity0 with @entity5 less than 62.5 mg/dL and low-density lipoprotein @entity1 less than 110 mg/dL had a 10.9-fold higher adjusted risk of mortality than low-Killip @entity0 with @entity5 greater than or equal to 62.5 mg/dL and low-density lipoprotein @entity1 greater than or equal to 110 mg/dL (p<0.001). The lipid paradox also improved @entity4 short-term outcomes prediction on original Killip and thrombolytic in @entity4 scores. CONCLUSIONS: Low low-density lipoprotein @entity1 , low @entity5 , and high Killip severity were associated with significantly higher 30-day in-hospital mortality in @entity0 presenting with @entity4 . The initial lipid profile of @entity0 with @entity4 may therefore hold prognostic value.

title: Lipid paradox in XXXX -the association with 30-day in-hospital mortality.

answer: @entity4


abstract: UNASSIGNED: Industrial wasteland soils with aged @entity3 and heavy metal contaminations are environments where pollutant @entity0 has been maintained for decades. Although the communities may be well adapted to the presence of stressors, knowledge about microbial diversity in such soils is scarce. Soil microbial community dynamics can be driven by the presence of plants, but the impact of plant development on selection or diversification of microorganisms in these soils has not been established yet. To test these hypotheses, aged-contaminated soil samples from a field trial were collected. Plots planted with alfalfa were compared to bare soil plots, and @entity1 and abundance were assessed after 2 and 6  years. Using pyrosequencing of 16S rRNA gene and ITS amplicons, we showed that the bacterial community was dominated by Proteobacteria, Actinobacteria, and Bacteroidetes and was characterized by low Acidobacteria abundance, while the fungal community was mainly represented by members of the Ascomycota. The short-term toxic impact of pollutants usually reduces the microbial diversity, yet in our samples bacterial and fungal species richness and diversity was high suggesting that the community structure and diversity adapted to the contaminated soil over decades. The presence of plants induced higher @entity1 than in bare soil. It also increased the relative abundance of bacterial members of the Actinomycetales, Rhizobiales, and Xanthomonadales orders and of most fungal orders. Multivariate analysis showed correlations between microbial community structure and heavy metal and @entity3 concentrations over time, but also with edaphic parameters (C/N, pH, @entity4 , and @entity2 concentrations).

title: The Bacterial and Fungal Diversity of an Aged XXXX - and Heavy Metal-Contaminated Soil is Affected by Plant Cover and Edaphic Parameters.

answer: @entity3


abstract: In the last decades, beef @entity2 breeding mainly focused on improving production and reproduction traits. Nowadays, there is a growing interest to include behavior and type traits in the breeding goal. There is an interest in behavior as it is associated with @entity0 safety and workability and in type traits as they might be associated with longevity of @entity2 . The objective of the current study was to estimate the heritability for behavior and type traits in Charolais and to estimate the genetic correlations among these traits. Behavior traits, including @entity1 at parturition, @entity1 during gestation period, and maternal care, were scored by farmers using an on-farm recording system to enable large-scale collection of phenotypes. Type traits, including udder traits ( = 3), teat traits (3), feet and leg traits (5), and locomotion (1), were scored by 10 trained classifiers. Data was available on 6,649 @entity2 in parity 1 to 12 and located in 380 herds. Results showed that differences between herds explained up to 23% of the total phenotypic variance in behavior traits. This might be due to differences in management or to consistent differences in scoring between farmers. @entity1 at parturition had higher heritability (0.19) and higher genetic coefficient of variation (CV = 11%) than @entity1 during gestation ( = 0.06 and CV = 4%) and maternal care ( = 0.02 and CV = 2%). Heritabilities for udder traits (0.14 to 0.20) and teat traits (0.17 to 0.35) were higher than for feet and leg traits (0.02 to 0.19). Genetic coefficients of variation for udder and teat traits were also higher (up to 21%) than for feet and leg traits (up to 11%). Strong genetic correlations were found between behavior traits (with absolute values from 0.71 to 0.98). The genetic correlations indicate that it is difficulty to simultaneously improve maternal care and reduce @entity1 . We concluded that there are good opportunities to implement selection for improved udder and teat traits and against @entity1 at parturition using a simple on-farm recording system of behavior.

title: Genetic parameters for large-scale behavior traits and type traits in Charolais beef XXXX .

answer: @entity2


abstract: We studied the prevalence of @entity1 in an unselected group of 708 adolescents aged 15-17 years. All subjects were physically examined and interviewed by the authors. The prevalence of past or present @entity4 was 5.7% in @entity0 and 3.1% in @entity0 . The figures for hay @entity2 were 14% and 8%, and for @entity3 ( @entity1 ) 25% and 30%, respectively. In 24% of all symptomatic subjects, the condition had not been active during the year preceding the study. The sex difference in the prevalence of hay @entity2 was significant. It is associated with higher immediate skin test reactivity in @entity0 . A progressive increase in the frequency of @entity1 was observed with increasing number of positive skin reactions in both @entity0 and @entity0 . Respiratory @entity5 was closely related to a positive skin test: 87% of the asthmatics and 83% of all those with @entity6 exhibited at least one positive skin reaction. For @entity3 the association was less pronounced. Nineteen per cent of the population studied had a positive symptom history and a positive skin test to pollens, animal epithelia or dusts indicating a clinically significant relationship. However, 39% of the 346 subjects with a positive skin test, including some with a large number of positive reactions, were completely asymptomatic.

title: XXXX and immediate skin test reactivity in Finnish adolescents.

answer: @entity1


abstract: BACKGROUND: @entity0 ( @entity0 ) are potential sources of morbidity in @entity3 ( @entity3 ). This is particularly true for those who perform follicular unit extraction (FUE). OBJECTIVE: To describe the nature, prevalence, and extent of ergonomic or work-related @entity0 among @entity3 . METHODS _ MATERIALS: A survey regarding @entity0 was e-mailed to 100 @entity3 . RESULTS: Thirty-eight @entity3 completed the survey, the majority of which were male and between the ages of 50-69. Fifty percent of respondents reported musculoskeletal symptoms occurring during or after hair restoration procedures. Reports of @entity1 during and after surgery were higher for FUE procedures than single strip excision procedures. @entity1 / @entity2 /discomfort persisted for longer following FUE procedures compared to strip excision procedures. @entity4 symptoms also negatively impacted quality of life. Although the majority of respondents felt that ergonomics was important, only 30% use ergonomic support when performing FUE procedures. CONCLUSION: Hair restoration surgeons should be aware of @entity4 symptoms and particularly when performing FUE. Symptoms reported included @entity1 , @entity2 , and discomfort, sometimes lasting several hours following surgery. More attention needs to be paid to ergonomics during hair restoration procedures in order to improve the quality of life of surgeons and ultimately prevent the development of @entity0 .

title: Ergonomics in XXXX .

answer: @entity3


abstract: BACKGROUND: The cutaneous signs of @entity6 are polymorphous and occasionally misleading. Herein, we report a rare case of profuse @entity6 involving various rare cutaneous signs specific to the disease associated with multiple @entity10 . @entity0 AND METHODS: A seventy-three-year-old @entity0 had been presenting @entity15 for 2 years. The examination also revealed diffuse cutaneous @entity4 with @entity11 , superficial adenopathy and pseudotumoral hypodermic masses. Ophthalmological examination revealed conjunctival nodules. Biopsy samples for the various cutaneous lesions, salivary glands, conjunctival nodules, a hypodermic nodule and an adenopathy yielded similar images evocative of epithelioid @entity9 and @entity14 without caseous @entity2 . Infectious causes were ruled out. Respiratory function tests showed a restrictive @entity13 . @entity12 levels were extremely high. @entity8 was noted for 24-hour urine tests and renal punch biopsy showed an appearance of membrane-proliferative @entity7 . Oral @entity5 produced clinical and laboratory improvement. Furthermore, the @entity0 was also presenting several invasive @entity10 in a setting of marked helioderma. DISCUSSION: Erythrodermic, ichthyosiform, atrophied, ulcerated and pseudotumoral forms of @entity6 are very uncommon and their simultaneous appearance in the same @entity0 is extremely rare. Further, the existence of numerous cutaneous @entity3 in this @entity0 raises the question of an association between @entity6 and @entity1 , with fortuitous association appearing unlikely.

title: [Profuse XXXX associated with multiple @entity10 ].

answer: @entity6


abstract: BACKGROUND: The cutaneous signs of @entity6 are polymorphous and occasionally misleading. Herein, we report a rare case of profuse @entity6 involving various rare cutaneous signs specific to the disease associated with multiple @entity10 . @entity0 AND METHODS: A seventy-three-year-old @entity0 had been presenting @entity15 for 2 years. The examination also revealed diffuse cutaneous @entity4 with @entity11 , superficial adenopathy and pseudotumoral hypodermic masses. Ophthalmological examination revealed conjunctival nodules. Biopsy samples for the various cutaneous lesions, salivary glands, conjunctival nodules, a hypodermic nodule and an adenopathy yielded similar images evocative of epithelioid @entity9 and @entity14 without caseous @entity2 . Infectious causes were ruled out. Respiratory function tests showed a restrictive @entity13 . @entity12 levels were extremely high. @entity8 was noted for 24-hour urine tests and renal punch biopsy showed an appearance of membrane-proliferative @entity7 . Oral @entity5 produced clinical and laboratory improvement. Furthermore, the @entity0 was also presenting several invasive @entity10 in a setting of marked helioderma. DISCUSSION: Erythrodermic, ichthyosiform, atrophied, ulcerated and pseudotumoral forms of @entity6 are very uncommon and their simultaneous appearance in the same @entity0 is extremely rare. Further, the existence of numerous cutaneous @entity3 in this @entity0 raises the question of an association between @entity6 and @entity1 , with fortuitous association appearing unlikely.

title: [Profuse @entity6 associated with multiple XXXX ].

answer: @entity10


abstract: BACKGROUND: The aim of this paper is to understand the process of information disclosure and privacy as @entity0 share their news of @entity1 with significant others. METHODS: Twenty @entity0 with @entity1 and 17 family members/friends accompanying them at diagnosis-giving completed either individual or dyad semi-structured interviews. Initial thematic analysis, then Petronio's Communication Privacy Management theory was used to inform interpretation. RESULTS: @entity0 described a sense of ownership of the news of their @entity2 and sought control of how, when and with whom it was shared. Family members expressed a need to follow the @entity0 ' rules in sharing this news, which limited their own support systems. @entity0 and family members had to live within the relational communication boundaries in order to maintain their trusting relationship and avoid potential disruptions. CONCLUSION: @entity0 as individuals are strongly interlinked with significant others, which impacts on their experience of disclosing private information. This shapes their psychological processes and outcomes impacting on their illness experience. This should be considered when developing interventions to support @entity0 with sharing bad news. Copyright    2015 John Wiley _ Sons, Ltd.

title: Sharing bad news of a XXXX diagnosis: understanding through communication privacy management theory.

answer: @entity1


abstract: During the years 1959 to 1978 inclusive 2165 @entity0 with @entity3 had vaginal deliveries at three large Dublin maternity hospitals. There were two (0.09%) cases of puerperal @entity2 , neither of which was unequivocally related to preceding childbirth during this period. Routine peripartum antibiotic prophylaxis was not given to either. A questionnaire of the practice of 19 obstetricians in Ireland showed that 12 (63%) gave antibiotics routinely during labour and after delivery in cardiac @entity0 , five (26%) did not, and two (11%) used them occasionally. Peripheral vein blood was drawn serially from 0 to 30 minutes after vaginal delivery to determine the incidence of asymptomatic @entity4 . A total of 299 cultures was obtained from 83 normal @entity0 and single blood cultures were positive in three @entity0 (3.6% of @entity0 , 1.0% of cultures). A review of the published reports showed that well-documented cases of @entity2 and of asymptomatic @entity4 after normal vaginal delivery are uncommon. There is evidence that antibiotic prophylaxis may increase the risk of developing antibiotic-resistant @entity2 . Recommended prophylactic regimens carry a considerable risk of @entity1 . These facts, coupled with a lack of direct evidence in support of the efficacy of antibiotic prophylaxis, suggest that routine peripartum antibiotic prophylaxis is not indicated.

title: Antibiotic prophylaxis against XXXX after normal delivery--is it necessary?

answer: @entity2


abstract: Comparative transcriptomics between species can provide valuable understanding of plant-pathogen interactions. Here, we focus on wild Solanum species and @entity1 clones with varying degree of resistance against @entity2 , which causes the devastating late @entity0 in @entity1 . The transcriptomes of three wild Solanum species native to Southern Sweden, Solanum dulcamara, Solanum nigrum, and Solanum physalifolium were compared to three @entity1 clones, Desiree (cv.), SW93-1015 and Sarpo Mira. Desiree and S. physalifolium are susceptible to @entity2 whereas the other four have different degrees of resistance. By building transcript families based on de novo assembled RNA-seq across species and clones and correlating these to resistance phenotypes, we created a novel workflow to identify families with expanded or depleted number of transcripts in relation to the @entity2 resistance level. Analysis was facilitated by inferring functional annotations based on the family structure and semantic clustering. More transcript families were expanded in the resistant clones and species and the enriched functions of these were associated to expected gene ontology (GO) terms for resistance mechanisms such as hypersensitive response, host programmed cell death and endopeptidase activity. However, a number of unexpected functions and transcripts were also identified, for example transmembrane transport and protein acylation expanded in the susceptible group and a cluster of Zinc knuckle family proteins expanded in the resistant group. Over 400 expressed putative resistance (R-)genes were identified and resistant clones Sarpo Mira and SW93-1015 had ca 25% more expressed putative R-genes than susceptible cultivar Desiree. However, no differences in numbers of susceptibility (S-)gene homologs were seen between species and clones. In addition, we identified @entity2 transcripts including effectors in the early stages of @entity2 -Solanum interactions.

title: A novel workflow correlating RNA-seq data to Phythophthora infestans resistance levels in wild Solanum species and XXXX clones.

answer: @entity1


abstract: UNASSIGNED: Systemic off-target @entity4 , including @entity7 , are prevalent side effects in @entity2 @entity1 treated with a number of otherwise highly efficacious anticancer drugs. In the current study, we have: (1) developed a new analytical metric for the in vivo preclinical assessment of systemic @entity4 / @entity7 of new drugs and delivery systems; and (2) evaluated, in @entity3 , the in vivo efficacy and @entity4 of a versatile and modular NanoDendron (ND) drug delivery and imaging platform that we recently developed. Our paclitaxel-carrying ND prodrug, ND(PXL), is activated following proteolytic cleavage by @entity5 , resulting in localized cytotoxic chemotherapy. Using click chemistry, we combined ND(PXL) with a traceable beacon, ND(PB), yielding ND(PXL)-ND(PB) that functions as a theranostic compound. In vivo fluorescence FRET imaging of this theranostic platform was used to confirm localized delivery to @entity2 and to assess the efficiency of drug delivery to @entity2 , achieving 25-30% activation in the @entity2 of an immunocompetent @entity3 model of @entity0 . In this model, ND-drug exhibited anti- @entity2 efficacy comparable to nab-paclitaxel, a clinical formulation. In addition, we combined neurobehavioral metrics of nociception and sensorimotor performance of individual @entity3 to develop a novel composite @entity4 score that reveals and quantifies peripheral @entity7 , a debilitating long-term systemic @entity4 of paclitaxel therapy. Importantly, @entity3 treated with nab-paclitaxel developed changes in behavioral metrics with significantly higher @entity4 scores indicative of @entity6 , while @entity3 treated with ND(PXL) showed no significant changes in behavioral responses or @entity4 score. Our ND formulation was designed to be readily adaptable to incorporate different drugs, imaging modalities and/or targeting motifs. This formulation has significant potential for preclinical and clinical tools across multiple disease states. The studies presented here report a novel @entity4 score for assessing @entity6 and demonstrate that our targeted, theranostic NDs are safe and effective, providing localized @entity2 delivery of a chemotherapeutic and with reduced common @entity7 side-effects.

title: New tools for the quantitative assessment of prodrug delivery and XXXX .

answer: @entity7


abstract: @entity1 ( @entity1 ) is one of the frequent causes of elevated mortality in salmonid aquaculture. Previously, we identified and validated microsatellites on chromosome Omy19 associated with QTL (quantitative trait loci) for @entity1 resistance and spleen size in @entity2 . Recently, SNPs (single @entity0 polymorphism) have become the markers of choice for genetic analyses in @entity2 as they are highly abundant, cost-effective and are amenable for high throughput genotyping. The objective of this study was to identify SNP markers associated with @entity1 resistance and spleen size using both genome-wide association studies (GWAS) and linkage-based QTL mapping approaches. A total of 298 offspring from the two half-sib families used in our previous study to validate the significant @entity1 QTL on chromosome Omy19 were genotyped with RAD-seq (restriction-site-associated DNA sequencing), and 7,849 informative SNPs were identified. Based on GWAS, 18 SNPs associated with @entity1 resistance and 20 SNPs associated with spleen size were identified. Linkage-based QTL mapping revealed three significant QTL for @entity1 resistance. In addition to the previously validated dam-derived QTL on chromosome Omy19, two significant @entity1 QTL derived from the sires were identified on chromosomes Omy8 and Omy25, respectively. A sire-derived significant QTL for spleen size on chromosome Omy2 was detected. The SNP markers reported in this study will facilitate fine mapping to identify positional candidate genes for @entity1 resistance in @entity2 .

title: Identification of single nucleotide polymorphism markers associated with bacterial cold water disease resistance and spleen size in XXXX .

answer: @entity2


abstract: Importance: The identification of genomic signatures that aid early identification of individuals at risk for @entity1 ( @entity1 ) in the toddler period remains a major challenge because of the genetic and phenotypic heterogeneity of the disorder. Generally, @entity1 is not diagnosed before the fourth to fifth birthday. Objective: To apply a functional genomic approach to identify a biologically relevant signature with promising performance in the diagnostic classification of @entity0 and toddlers with @entity1 . Design, Setting, and @entity0 : Proof-of-principle study of leukocyte RNA expression levels from 2 independent cohorts of @entity0 aged 1 to 4 years (142 discovery @entity0 and 73 replication @entity0 ) using Illumina microarrays. Coexpression analysis of differentially expressed genes between Discovery @entity1 and control toddlers were used to define gene modules and eigengenes used in a diagnostic classification analysis. Independent validation of the classifier performance was tested on the replication cohort. Pathway enrichment and protein-protein interaction analyses were used to confirm biological relevance of the functional networks in the classifier. @entity0 recruitment occurred in general pediatric clinics and community settings. Male @entity0 and toddlers (age range, 1-4 years) were enrolled in the study. Recruitment criteria followed the 1-Year Well-Baby Check-Up Approach. Diagnostic judgment followed DSM-IV-TR and @entity2 Diagnostic Observation Schedule criteria for @entity2 . @entity0 with @entity1 were compared with control groups composed of typically developing toddlers as well as toddlers with global developmental or @entity3 . Main Outcomes and Measures: Logistic regression and receiver operating characteristic curve analysis were used in a classification test to establish the accuracy, specificity, and sensitivity of the module-based classifier. Results: Our signature of differentially coexpressed genes was enriched in translation and immune/inflammation functions and produced 83% accuracy. In an independent test with approximately half of the sample and a different microarray, the diagnostic classification of @entity1 vs control samples was 75% accurate. Consistent with its @entity1 specificity, our signature did not distinguish toddlers with global developmental or @entity3 from typically developing toddlers (62% accuracy). Conclusions and Relevance: This proof-of-principle study demonstrated that genomic biomarkers with very good sensitivity and specificity for @entity0 with @entity1 in general pediatric settings can be identified. It also showed that a blood-based clinical test for at-risk male @entity0 and toddlers could be refined and routinely implemented in pediatric diagnostic settings.

title: Prediction of XXXX by Translation and Immune/Inflammation Coexpressed Genes in Toddlers From Pediatric Community Practices.

answer: @entity2