abstract: BACKGROUND Most @entity9 , including @entity8 , are benign and asymptomatic. Rapid enlargement, @entity7 , @entity3 , rupture with leakage of cyst contents, or pressure on adjacent organs can cause symptoms. Although usually diagnosed incidentally on imaging, determining the origin of a cyst can sometimes be challenging. In these situations, surgical excision and pathological analysis is crucial to diagnosis and management. We report here a case of a giant symptomatic @entity8 that closely mimicked a @entity1 at presentation. CASE REPORT A 50-year-old @entity0 , with a history of an incidentally detected @entity1 , presented with severe @entity5 , @entity2 , @entity6 , and mildly abnormal liver function tests. CT scan revealed a large well defined cystic space-occupying lesion within the liver, with findings suggesting @entity4 and possible @entity3 . Early laparotomy was performed, and the origin was determined intraoperatively to be right adrenal, which was later confirmed by pathology. CONCLUSIONS Contrast-enhanced CT scan is the criterion standard for evaluation for abdominal cystic masses. Precise diagnosis of a giant abdominal cyst can be challenging. Surgery is both diagnostic and curative in such situations. We also discuss the specific situations in which surgery should be considered in cases of adrenal cystic masses.

title: All Those Liver Masses are not Necessarily from the Liver: A Case of a Giant Adrenal Pseudocyst Mimicking a XXXX .

answer: @entity1


abstract: BACKGROUND: Identifying unwarranted variation in health care can highlight opportunities to reduce harm. One often discretionary process in oncology is use of implanted ports to administer intravenous chemotherapy. While there are benefits, ports carry risks. This study's objective was to assess provider-driven variation in port use among @entity1 @entity0 receiving chemotherapy. RESEARCH DESIGN: Retrospective assessment using population-based SEER-Medicare data to assess differences in port use across health care providers of older adults with @entity1 . @entity0 included over 18,000 @entity0 ages 66 and older diagnosed with breast, @entity2 in 2005-2007, treated by approximately 2900 providers. We identified port use for @entity0 receiving treatment from hospital outpatient facilities versus physicians' offices. Our main analysis assessed the likelihood of a @entity0 receiving a port given port use by the provider's last @entity0 . For a subset of high-use providers, we examined individual provider-level variation by estimating the risk-adjusted likelihood of insertion. RESULTS: @entity0 receiving chemotherapy in hospital outpatient facilities were significantly less likely to receive a port than those treated in physicians' offices, with adjusted odds ratios (AOR) varying from 0.50 to 0.75 across @entity1 sites. Implanting a port was associated with increased likelihood of port insertion in the provider's next @entity0 (AOR varied from 1.71 to 2.25). Significant between-provider variation was found among providers with at least 10 @entity0 . CONCLUSIONS: Our findings support the idea that there is provider-driven variation in the use of ports for chemotherapy administration. This variation highlights an opportunity to standardize practice and reduce unnecessary use.

title: Provider Differences in Use of Implanted Ports in Older Adults With XXXX .

answer: @entity1


abstract: PURPOSE: To discuss the clinical findings in a unique case of @entity4 with a focus on the pathophysiology of this rare entity. METHODS: The @entity0 's clinical course was documented with color fundus photography and spectral domain ocular coherence tomography registered to infrared reflectance imaging. The visual field was assessed using the Amsler grid testing and Humphrey visual field 24-2. RESULTS: Initial fundus photography showed @entity6 wool spots and slight darkening of the central macula in each eye. Optical coherence tomography showed @entity5 at the level of the outer plexiform layer/outer nuclear layer junction with subsequent thinning of the outer nuclear layer and corresponding disruption of the ellipsoid and outer segment/retinal pigment epithelium. Infrared reflectance imaging revealed @entity2 in each eye with corresponding @entity3 on the Amsler grid and visual field testing. The hyporeflective infrared lesions became more discreet during the ensuing weeks and remained stable beyond 11 weeks. CONCLUSION: The authors present the case of a 15-year-old @entity0 diagnosed with @entity4 . This case is notable in that she presented with @entity6 wool spots and intraretinal fluid, both of which are unusual for @entity4 . The authors suggest that the presence of @entity6 wool spots and several small foci of intraretinal fluid seen in their @entity0 may lend support to the @entity1 hypothesis described by Sarraf et al. The optical coherence tomography images obtained in this case have the typical wedge-shaped or petaloid configuration, and the authors suggest that the shape of the lesions themselves also lends support to a vascular mechanism.

title: A UNIQUE CASE OF ACUTE MACULAR NEURORETINOPATHY ASSOCIATED WITH XXXX WOOL SPOTS AND INTRARETINAL FLUID.

answer: @entity6


abstract: Between 1991 and 2000 about 1500 @entity0 fell ill in Germany (Baden-Wuerttemberg, Bavaria, Hesse) after infection with the @entity7 ( @entity7 ) virus. Detailed clinical and epidemiological data of @entity7 were available from 850 @entity0 . A biphasic course of the disease occurred in 75% of @entity0 . @entity7 presented as @entity2 in 400 @entity0 (47%), as @entity6 in 356 (42%) and as meningoencephalomyelitis in 93 (11%). Nine of the @entity0 (1%) died from @entity7 . Five hundred and ninety three @entity0 (70%) had noticed a tick bite and the first symptoms occurred, on average, seven days later. The most frequent @entity1 were an @entity4 (31%), @entity5 (18%) and paresis of the extremities (15%) and cranial nerves (11%). Laboratory investigations revealed @entity3 in 74% of the @entity0 , elevation of the sedimentation rate in 91%, increased C-reactive protein in 82%, pleocytosis in the CSF of all @entity0 tested, damage of the blood-CSF-barrier in 79%, abnormalities in EEG in 77% and abnormalities in MRI in 18%. In general, adolescents up to 14 years of age had a more favourable course of the disease than adults. In view of the severity of the illness and the high frequency of sequelae, active immunisation against @entity7 is recommended for all subjects living in and travelling to areas of risk. Regarding the higher risk of severe manifestations of @entity7 in the elderly @entity0 and the higher risk of failure of immunisation in this population, vaccination against @entity7 is more important in elderly subjects than in very young @entity0 . Prevention of @entity7 by post exposure prophylaxis with hyperimmunoglobulins is less effective and should therefore not be performed.

title: XXXX ( @entity7 ) in Germany and clinical course of the disease.

answer: @entity7


abstract: Between 1991 and 2000 about 1500 @entity0 fell ill in Germany (Baden-Wuerttemberg, Bavaria, Hesse) after infection with the @entity7 ( @entity7 ) virus. Detailed clinical and epidemiological data of @entity7 were available from 850 @entity0 . A biphasic course of the disease occurred in 75% of @entity0 . @entity7 presented as @entity2 in 400 @entity0 (47%), as @entity6 in 356 (42%) and as meningoencephalomyelitis in 93 (11%). Nine of the @entity0 (1%) died from @entity7 . Five hundred and ninety three @entity0 (70%) had noticed a tick bite and the first symptoms occurred, on average, seven days later. The most frequent @entity1 were an @entity4 (31%), @entity5 (18%) and paresis of the extremities (15%) and cranial nerves (11%). Laboratory investigations revealed @entity3 in 74% of the @entity0 , elevation of the sedimentation rate in 91%, increased C-reactive protein in 82%, pleocytosis in the CSF of all @entity0 tested, damage of the blood-CSF-barrier in 79%, abnormalities in EEG in 77% and abnormalities in MRI in 18%. In general, adolescents up to 14 years of age had a more favourable course of the disease than adults. In view of the severity of the illness and the high frequency of sequelae, active immunisation against @entity7 is recommended for all subjects living in and travelling to areas of risk. Regarding the higher risk of severe manifestations of @entity7 in the elderly @entity0 and the higher risk of failure of immunisation in this population, vaccination against @entity7 is more important in elderly subjects than in very young @entity0 . Prevention of @entity7 by post exposure prophylaxis with hyperimmunoglobulins is less effective and should therefore not be performed.

title: @entity7 ( XXXX ) in Germany and clinical course of the disease.

answer: @entity7


abstract: PURPOSE: (a) To report the medical complexity of @entity1 and noncancer @entity0 receiving palliative medicine (PM) consultation at a tertiary medical center and (b) to describe the consult recommendations madefor this group. @entity0 AND METHODS: Prospective data collection was performed on all consultations ( @entity1 , n = 175; noncancer, n = 35) done by first author (JDC) as a PM fellow at the Cleveland Clinic Foundation between July 1998 and April 1999. A computer database was used to query for demographics, complexity of medical problems, current medications, mortality, symptoms, nursing problems, and consult recommendations. RESULTS: A median of three (range, 0-12) acute medical problems and three (range, 0-16) chronic medical problems were identified for each @entity0 . @entity0 were taking a median of six medications (range, 0-20). They had a median of five symptoms (range, 0-13) with @entity2 (73 percent) being most common, followed by @entity3 (40 percent) and @entity4 (40 percent). @entity1 @entity0 were twice as likely to have more than five symptoms (48 percent versus 23 percent) (chi-square = 0.006). The most common nursing problems were ambulation or fall risk (15 percent) and skin integrity (11 percent). A median of five (range, 1-11) management recommendations were made as part of each consultation. These included medication changes in 81 percent, nonmedication changes in 53 percent, andfollow-up services in 100 percent. The median survivalfrom the time of consultation for the known dead was 29 days with 65 percent living more than 14 days. CONCLUSION: Multiple recommendations were made with most @entity0 surviving long enough potentially to benefit. Consultation in palliative medicine is a sophisticated intervention involving considerable acuity and complexity of care.

title: Palliative medicine in a United States XXXX center: a prospective study.

answer: @entity1


abstract: PURPOSE: Delayed chemotherapy-induced @entity5 (CINV) remains an important adverse effect of moderately emetogenic chemotherapy not containing @entity8 and @entity3 (non-AC MEC). In this review, we summarize current literature to update recommendations for delayed @entity5 after non-AC MEC. METHODS: We conducted a systematic search in PubMed and conference proceedings from ASCO, ESMO, and MASCC. Included randomized controlled trials (RCTs) aimed to prospectively evaluate the efficacy of two or more antiemetic strategies in the prevention of delayed CINV after the administration of non-AC MEC. At least one of the following endpoints was used: complete response, complete control, no @entity0 , no @entity1 , and/or no use of rescue medication. RESULTS: Our search provided 247 publications. Nine met the predefined criteria. Included RCTs reported outcomes on @entity7 , aprepitant, casopitant, netupitant/ @entity7 (NEPA), @entity4 , and @entity6 . CONCLUSIONS: Superiority of @entity7 over first-generation 5-HT3 receptor antagonists for the prevention of acute and delayed CINV after non-AC MEC has not been proven. The addition of an @entity9 antagonist to first-generation 5-HT3 receptor antagonists does not significantly improve the incidence of delayed CINV after non-AC MEC. The efficacy of a single-day regimen of @entity2 with @entity7 is non-inferior to multiday @entity2 . NEPA, @entity4 , and @entity6 show highly effective complete response (CR) rates.

title: Prophylactic treatment for delayed chemotherapy-induced XXXX after non-AC based moderately emetogenic chemotherapy: a systematic review of randomized controlled trials.

answer: @entity5


abstract: @entity7 , especially of high grade, is dependent on neovascularization for its growth and progression. The expression of @entity2 ( @entity2 -A), an important angiogenesis factor, has been demonstrated in perinecrotic cells in @entity5 . In order to achieve more knowledge regarding the process of @entity7 angiogenesis and growth we have investigated the expression of @entity2 immunohistochemically in different areas of @entity1 . In 21 @entity0 with @entity7 of varying grade serial stereotactic biopsies were performed. Biopsies were taken from brain adjacent to @entity1 (BAT), @entity1 periphery, and @entity1 center. In the BAT region of high-grade @entity7 , we found a frequent expression of @entity2 in @entity1 cells and less frequent in blood vessels. In the periphery, there was an expression mainly in @entity1 cells while in the center of grade IV @entity1 @entity2 was also frequently expressed in cells adjacent to @entity3 . @entity2 in @entity7 grade II was demonstrated in viable @entity1 cells preferentially in the periphery but also in peripheral vessels and in centrally located @entity1 cells. The findings indicate that, in addition to @entity6 in @entity3 areas there may be other factors that stimulate the expression of @entity2 . It is suggested that @entity2 may be a prerequisite for the @entity4 and infiltrative growth of @entity7 . Therefore, when operating high-grade @entity7 it may be of importance to resect this @entity4 peripheral part of the @entity1 and also to take this finding into account when planning radiotherapy.

title: Spatial expression of XXXX in @entity0 glioma.

answer: @entity2


abstract: @entity7 , especially of high grade, is dependent on neovascularization for its growth and progression. The expression of @entity2 ( @entity2 -A), an important angiogenesis factor, has been demonstrated in perinecrotic cells in @entity5 . In order to achieve more knowledge regarding the process of @entity7 angiogenesis and growth we have investigated the expression of @entity2 immunohistochemically in different areas of @entity1 . In 21 @entity0 with @entity7 of varying grade serial stereotactic biopsies were performed. Biopsies were taken from brain adjacent to @entity1 (BAT), @entity1 periphery, and @entity1 center. In the BAT region of high-grade @entity7 , we found a frequent expression of @entity2 in @entity1 cells and less frequent in blood vessels. In the periphery, there was an expression mainly in @entity1 cells while in the center of grade IV @entity1 @entity2 was also frequently expressed in cells adjacent to @entity3 . @entity2 in @entity7 grade II was demonstrated in viable @entity1 cells preferentially in the periphery but also in peripheral vessels and in centrally located @entity1 cells. The findings indicate that, in addition to @entity6 in @entity3 areas there may be other factors that stimulate the expression of @entity2 . It is suggested that @entity2 may be a prerequisite for the @entity4 and infiltrative growth of @entity7 . Therefore, when operating high-grade @entity7 it may be of importance to resect this @entity4 peripheral part of the @entity1 and also to take this finding into account when planning radiotherapy.

title: Spatial expression of @entity2 in XXXX glioma.

answer: @entity0


abstract: We have evaluated morphologic alterations and epithelial cell apoptosis and proliferation of colonic mucosa in the acute and chronic phases of @entity9 -induced @entity6 . @entity6 was induced in @entity4 by 7 days of 4% @entity9 oral administration followed by 7 days of tap water for one, two, and three cycles. Control @entity4 receved tap water only. Morphological changes in colonic mucosa were evaluated and scored by light and scanning electron microscopy. Apoptosis was studied by TUNEL assay and cell proliferation by Ki-67 immunoreaction. The expression of both proapoptotic (Fas, @entity10 , @entity7 , @entity8 ) and antiapoptotic (Bc12) cellular proteins was determined by immunohistochemistry. Morphologic assessment showed the most severe @entity5 and @entity3 in the distal colon with a trend to increasing severity from the first to the third @entity9 cycle. In @entity9 @entity4 , the epithelial apoptotic index increased 20-fold after the first cycle and 120-fold after the second and third cycles compared with the controls; in the same way, the expression index of proapoptotic proteins (Fas, @entity10 , @entity7 , @entity8 ) dramatically increased. The proliferative index increased about 40 to 60-fold compared to controls, with no difference among the three @entity9 cycles. In conclusion, @entity9 -induced @entity6 in @entity4 , which has many structural and ultrastructural features similar to those seen in @entity0 @entity2 , is a suitable model for studying increased epithelial apoptosis and proliferation. Further studies employing this model will permitt two hypotheses to be tested. (1) Increased apoptosis may lead to a breakdown of the epithelial barrier function and facilitate the mucosal invasion of intraluminal microorganisms and/or antigens. (2) Abnormal and persistent epithelial hyperproliferation could be causally related to the development of @entity1 in the setting of chronic @entity3 .

title: Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced XXXX in @entity4 .

answer: @entity6


abstract: We have evaluated morphologic alterations and epithelial cell apoptosis and proliferation of colonic mucosa in the acute and chronic phases of @entity9 -induced @entity6 . @entity6 was induced in @entity4 by 7 days of 4% @entity9 oral administration followed by 7 days of tap water for one, two, and three cycles. Control @entity4 receved tap water only. Morphological changes in colonic mucosa were evaluated and scored by light and scanning electron microscopy. Apoptosis was studied by TUNEL assay and cell proliferation by Ki-67 immunoreaction. The expression of both proapoptotic (Fas, @entity10 , @entity7 , @entity8 ) and antiapoptotic (Bc12) cellular proteins was determined by immunohistochemistry. Morphologic assessment showed the most severe @entity5 and @entity3 in the distal colon with a trend to increasing severity from the first to the third @entity9 cycle. In @entity9 @entity4 , the epithelial apoptotic index increased 20-fold after the first cycle and 120-fold after the second and third cycles compared with the controls; in the same way, the expression index of proapoptotic proteins (Fas, @entity10 , @entity7 , @entity8 ) dramatically increased. The proliferative index increased about 40 to 60-fold compared to controls, with no difference among the three @entity9 cycles. In conclusion, @entity9 -induced @entity6 in @entity4 , which has many structural and ultrastructural features similar to those seen in @entity0 @entity2 , is a suitable model for studying increased epithelial apoptosis and proliferation. Further studies employing this model will permitt two hypotheses to be tested. (1) Increased apoptosis may lead to a breakdown of the epithelial barrier function and facilitate the mucosal invasion of intraluminal microorganisms and/or antigens. (2) Abnormal and persistent epithelial hyperproliferation could be causally related to the development of @entity1 in the setting of chronic @entity3 .

title: Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced @entity6 in XXXX .

answer: @entity4


abstract: OBJECTIVES: To evaluate the social awareness of the risk of nuts @entity1 and the relationship with the occupation of parents. MATERIAL AND METHODS: From January 2013 to January 2014, a self-designed survey was distributed to 247 parents of @entity0 under 14 years admitted to our centre, regardless of the reason for admission. The statistical significance was calculated using confidence intervals (CI). The Pearson Chi-square test was used to analyse the ignorance of this problem depending on the educational level extrapolated from the occupation of respondents. RESULTS: 247 parents responded to the survey. 60.3% (95% CI 54.1-66.2%) confirmed that nuts were included in birthday parties. 30.4% (95% CI 25-36.4%) confirmed that celebrations with nuts at their @entity0 's nursery were made. 42.1% (95% CI 36.1-48.3%) believed that nuts were harmless for their young @entity0 . The age of administration of nuts was independent on the educational level extrapolated of parents (  2 = 10.721, p = 0.295), although it did influence on the ignorance of the danger of nuts (41.2% (95% CI 30.3-53%) of respondents with occupations that required higher educational level compared to 55.4% (95% CI 42.4-67.6%) of those with occupation that required less educational level (  2 = 14.678, p = 0.002)). CONCLUSIONS: Regardless of the occupation, there is widespread ignorance concerning the age of introduction of nuts in @entity0 's diet. Given the incidence and severity of the risk of @entity1 , more prevention programs are necessary, and Health Authorities should take side in public awareness of this problem.

title: [Is the awareness of the risk of nuts XXXX related to the occupation of parents?].

answer: @entity1


abstract: Some @entity0 develop @entity2 ( @entity2 ) after the clipping/coating of unruptured @entity1 . The risk factors are not well understood and while no preventive methods are currently available, arachnoid plasty (ARP) may intercept the development of postoperative @entity3 . We investigated the risk factors for @entity3 and the usefulness of ARP to prevent postoperative @entity3 . Between January 2009 and June 2013, 393 @entity0 underwent 416 @entity1 surgeries via the pterional approach at Kushiro Kojinkai Memorial Hospital. Of these, 394 @entity1 (371 @entity0 ) were included in this study. Using multivariate analysis we evaluated the relationship between the @entity0 demographics and clinical characteristics, and the development of postoperative symptomatic @entity3 . We also studied the effect of ARP performed during @entity1 surgery. We found that symptomatic @entity3 developed after 20 (5.1%) of the 394 operations; it was addressed by burr hole surgery and evacuation/irrigation. Male gender, advanced age, and oral anticoagulant therapy were significant risk factors for @entity3 . Additive ARP, performed in the course of 132 surgeries (33.5%) was found to be a significant negative risk factor. The incidence of @entity3 was significantly lower in @entity0 who had undergone ARP than in @entity0 who had not undergone it (0.8% vs. 7.3%, p < 0.01). We first report that ARP is useful for the prevention of @entity3 in @entity0 treated by @entity1 surgery.

title: Intraoperative Arachnoid Plasty Has Possibility to Prevent XXXX after Surgery for Unruptured Cerebral Aneurysms.

answer: @entity2


abstract: AIMS: To evaluate signs of ischaemia and @entity4 in relation to gender and sympathoadrenal activity in @entity0 with stable @entity5 and healthy controls. MATERIAL AND METHODS: 809 @entity0 (248 females) with stable @entity5 , and 50 matched healthy controls performed an exercise test and an ambulatory ECG recording. @entity8 were measured in plasma before and immediately after exercise, and in urine during ambulatory ECG. RESULTS: Male and female @entity0 showed similar frequencies of @entity2 , similar blood pressure and @entity9 responses on exercise testing. Females had higher heart rates and were more prone towards silent ischaemia. The healthy controls exercised longer and showed greater adrenaline responses. During ambulatory ECG, the two genders had similar duration of @entity2 , but males had more @entity7 . Females excreted more @entity6 , and had higher minimal and maximal heart rates. @entity7 were equally common among @entity0 and controls, but controls had greater @entity9 excretion. @entity2 during exercise was positively related to the duration of @entity2 during ambulatory ECG for both genders. Exercise time until @entity2 was inversely related to the duration of @entity2 during ambulatory ECG among male @entity0 only. @entity9 responses during exercise testing were more closely correlated to time until @entity3 than to signs of ischaemia. CONCLUSION: Mechanisms behind @entity1 and @entity4 may differ in male and female @entity0 , as females seem to be more prone towards silent ischaemia. Ischaemia on exercise correlated to ambulatory ischaemia among males only.

title: Ischaemia during exercise and ambulatory monitoring in @entity0 with stable @entity5 and healthy controls. Gender differences and relationships to XXXX .

answer: @entity8


abstract: AIMS: To evaluate signs of ischaemia and @entity4 in relation to gender and sympathoadrenal activity in @entity0 with stable @entity5 and healthy controls. MATERIAL AND METHODS: 809 @entity0 (248 females) with stable @entity5 , and 50 matched healthy controls performed an exercise test and an ambulatory ECG recording. @entity8 were measured in plasma before and immediately after exercise, and in urine during ambulatory ECG. RESULTS: Male and female @entity0 showed similar frequencies of @entity2 , similar blood pressure and @entity9 responses on exercise testing. Females had higher heart rates and were more prone towards silent ischaemia. The healthy controls exercised longer and showed greater adrenaline responses. During ambulatory ECG, the two genders had similar duration of @entity2 , but males had more @entity7 . Females excreted more @entity6 , and had higher minimal and maximal heart rates. @entity7 were equally common among @entity0 and controls, but controls had greater @entity9 excretion. @entity2 during exercise was positively related to the duration of @entity2 during ambulatory ECG for both genders. Exercise time until @entity2 was inversely related to the duration of @entity2 during ambulatory ECG among male @entity0 only. @entity9 responses during exercise testing were more closely correlated to time until @entity3 than to signs of ischaemia. CONCLUSION: Mechanisms behind @entity1 and @entity4 may differ in male and female @entity0 , as females seem to be more prone towards silent ischaemia. Ischaemia on exercise correlated to ambulatory ischaemia among males only.

title: Ischaemia during exercise and ambulatory monitoring in @entity0 with stable XXXX and healthy controls. Gender differences and relationships to @entity8 .

answer: @entity5


abstract: AIMS: To evaluate signs of ischaemia and @entity4 in relation to gender and sympathoadrenal activity in @entity0 with stable @entity5 and healthy controls. MATERIAL AND METHODS: 809 @entity0 (248 females) with stable @entity5 , and 50 matched healthy controls performed an exercise test and an ambulatory ECG recording. @entity8 were measured in plasma before and immediately after exercise, and in urine during ambulatory ECG. RESULTS: Male and female @entity0 showed similar frequencies of @entity2 , similar blood pressure and @entity9 responses on exercise testing. Females had higher heart rates and were more prone towards silent ischaemia. The healthy controls exercised longer and showed greater adrenaline responses. During ambulatory ECG, the two genders had similar duration of @entity2 , but males had more @entity7 . Females excreted more @entity6 , and had higher minimal and maximal heart rates. @entity7 were equally common among @entity0 and controls, but controls had greater @entity9 excretion. @entity2 during exercise was positively related to the duration of @entity2 during ambulatory ECG for both genders. Exercise time until @entity2 was inversely related to the duration of @entity2 during ambulatory ECG among male @entity0 only. @entity9 responses during exercise testing were more closely correlated to time until @entity3 than to signs of ischaemia. CONCLUSION: Mechanisms behind @entity1 and @entity4 may differ in male and female @entity0 , as females seem to be more prone towards silent ischaemia. Ischaemia on exercise correlated to ambulatory ischaemia among males only.

title: Ischaemia during exercise and ambulatory monitoring in XXXX with stable @entity5 and healthy controls. Gender differences and relationships to @entity8 .

answer: @entity0


abstract: @entity2 or @entity5 (TM or TBM) is a common problem especially for elderly @entity0 often unfit for surgical techniques. Several surgical or minimally invasive techniques have already been described. Stenting is one option but in general long-time stenting is accompanied by a high complication rate. Stent removal is more difficult in case of self-expandable @entity4 stents or metallic stents in general in comparison to @entity3 stents. The main disadvantage of @entity3 stents in comparison to uncovered metallic stents is migration and plugging. We compared the operation time and in particular the duration of a sufficient Dumon stent fixation with different techniques in a @entity0 with severe posttracheotomy TM and strongly reduced mobility of the vocal cords due to @entity1 . The combined approach with simultaneous Dumon stenting and endoluminal transtracheal externalized suture under cone-beam computer tomography guidance with the Berci needle was by far the fastest approach compared to a (not performed) surgical intervention, or even purely endoluminal suturing through the rigid bronchoscope. The duration of the endoluminal transtracheal externalized suture was between 5 minutes and 9 minutes with the Berci needle; the pure endoluminal approach needed 51 minutes. The alternative of tracheobronchoplasty was refused by the @entity0 . In general, 180 minutes for this surgical approach is calculated. The costs of the different approaches are supposed to vary widely due to the fact that in Germany 1 minute in an operation room costs on average approximately 50-60    inclusive of taxes. In our own hospital (tertiary level), it is nearly 30    per minute in an operation room for a surgical approach. Calculating an additional 15 minutes for @entity0 preparation and transfer to wake-up room, therefore a total duration inside the investigation room of 30 minutes, the cost per flexible bronchoscopy is per minute on average less than 6   . Although the Dumon stenting requires a set-up with more expensive anesthesiology accompaniment, which takes longer than a flexible investigation estimated at 1 hour in an operation room, still without calculation of the costs of the materials and specialized staff that the surgical approach would consume at least 3,000    more than a minimally invasive approach performed with the Berci needle. This difference is due to the longer time of the surgical intervention which is calculated at approximately 180 minutes in comparison to the achieved non-surgical approach of 60 minutes in the operation suite.

title: Transtracheal single-point stent fixation in posttracheotomy XXXX under cone-beam computer tomography guidance by transmural suturing with the Berci needle - a perspective on a new tool to avoid stent migration of Dumon stents.

answer: @entity2


abstract: BACKGROUND: @entity9 , the root of @entity9 (PG), is used widely as a herbal medicine to prevent and treat @entity1 . @entity9 has pharmacological effects on @entity2 such as @entity3 ( @entity3 ). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced @entity3 in a @entity0 model. METHODS: Advanced glycation end products were injected bilaterally into the CA3 region of the @entity0 ' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell ( @entity8 ). RESULTS: Behavioral results showed that PG (1  g/kg, 0.5  g/kg, and 0.25  g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in @entity0 with AGE-induced @entity3 . @entity9 also significantly reduced the @entity5 level, increased the @entity6 content, and increased @entity4 dismutase activity in the hippocampus. @entity9 significantly decreased the expression of @entity10 and @entity8 . The blockade of anti- @entity10 antibody could significantly reduce AGE-induced impairments and regulate these expressions. CONCLUSION: Our results demonstrated that PG significantly inhibits AGE-induced @entity7 and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the @entity10 / @entity8 pathway. Our results provided the experimental basis for applying PG in preventing and treating @entity3 .

title: @entity9 improves cognitive deficit via the XXXX / @entity8 pathway in advanced glycation end product-induced @entity0 .

answer: @entity10


abstract: BACKGROUND: @entity9 , the root of @entity9 (PG), is used widely as a herbal medicine to prevent and treat @entity1 . @entity9 has pharmacological effects on @entity2 such as @entity3 ( @entity3 ). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced @entity3 in a @entity0 model. METHODS: Advanced glycation end products were injected bilaterally into the CA3 region of the @entity0 ' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell ( @entity8 ). RESULTS: Behavioral results showed that PG (1  g/kg, 0.5  g/kg, and 0.25  g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in @entity0 with AGE-induced @entity3 . @entity9 also significantly reduced the @entity5 level, increased the @entity6 content, and increased @entity4 dismutase activity in the hippocampus. @entity9 significantly decreased the expression of @entity10 and @entity8 . The blockade of anti- @entity10 antibody could significantly reduce AGE-induced impairments and regulate these expressions. CONCLUSION: Our results demonstrated that PG significantly inhibits AGE-induced @entity7 and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the @entity10 / @entity8 pathway. Our results provided the experimental basis for applying PG in preventing and treating @entity3 .

title: @entity9 improves cognitive deficit via the @entity10 / XXXX pathway in advanced glycation end product-induced @entity0 .

answer: @entity8


abstract: BACKGROUND: @entity9 , the root of @entity9 (PG), is used widely as a herbal medicine to prevent and treat @entity1 . @entity9 has pharmacological effects on @entity2 such as @entity3 ( @entity3 ). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced @entity3 in a @entity0 model. METHODS: Advanced glycation end products were injected bilaterally into the CA3 region of the @entity0 ' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell ( @entity8 ). RESULTS: Behavioral results showed that PG (1  g/kg, 0.5  g/kg, and 0.25  g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in @entity0 with AGE-induced @entity3 . @entity9 also significantly reduced the @entity5 level, increased the @entity6 content, and increased @entity4 dismutase activity in the hippocampus. @entity9 significantly decreased the expression of @entity10 and @entity8 . The blockade of anti- @entity10 antibody could significantly reduce AGE-induced impairments and regulate these expressions. CONCLUSION: Our results demonstrated that PG significantly inhibits AGE-induced @entity7 and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the @entity10 / @entity8 pathway. Our results provided the experimental basis for applying PG in preventing and treating @entity3 .

title: XXXX improves cognitive deficit via the @entity10 / @entity8 pathway in advanced glycation end product-induced @entity0 .

answer: @entity9


abstract: BACKGROUND: @entity9 , the root of @entity9 (PG), is used widely as a herbal medicine to prevent and treat @entity1 . @entity9 has pharmacological effects on @entity2 such as @entity3 ( @entity3 ). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced @entity3 in a @entity0 model. METHODS: Advanced glycation end products were injected bilaterally into the CA3 region of the @entity0 ' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell ( @entity8 ). RESULTS: Behavioral results showed that PG (1  g/kg, 0.5  g/kg, and 0.25  g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in @entity0 with AGE-induced @entity3 . @entity9 also significantly reduced the @entity5 level, increased the @entity6 content, and increased @entity4 dismutase activity in the hippocampus. @entity9 significantly decreased the expression of @entity10 and @entity8 . The blockade of anti- @entity10 antibody could significantly reduce AGE-induced impairments and regulate these expressions. CONCLUSION: Our results demonstrated that PG significantly inhibits AGE-induced @entity7 and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the @entity10 / @entity8 pathway. Our results provided the experimental basis for applying PG in preventing and treating @entity3 .

title: @entity9 improves cognitive deficit via the @entity10 / @entity8 pathway in advanced glycation end product-induced XXXX .

answer: @entity0


abstract: INTRODUCTION, AIMS, AND METHODS: Industrial countries' societies are challenged to counter the increasing costs of health care. The preponderance of @entity1 in middle-aged @entity0 demands new strategies to reduce the extremely high rates of early deaths and increased morbidity and thus to avert considerable costs. Prevention programmes are appropriate means to combine therapeutic needs with health economic goals. A review of techniques of economic evaluation is given, from which a critical appraisal of cost-effectiveness analyses in primary and secondary prevention with @entity3 reductase inhibitors in @entity2 follows. Our own analysis of cost-effectiveness of primary prevention based on the clinical results of the WOSCOP study is also presented. RESULTS AND CONCLUSIONS: Long-term treatment with @entity3 reductase inhibitors is effective (30% mortality reduction), safe and tolerable. With a cost-effectiveness ratio of DM15,000-25,000/life-year saved ( 9000-15,000) it can be recommended for secondary prevention. The application of statins in primary prevention has also proved to be clinically effective. But with a cost-effectiveness ratio of DM330,000/life-year saved ( 195,000) they cannot be generally advocated in @entity0 with hypercholesterolaemia. However, the treatment has to be considered for high risk @entity0 . Aspirin prevention seems to be an alternative in @entity0 without additional risk factors.

title: Cost-effectiveness of primary and secondary prevention in XXXX .

answer: @entity1


abstract: BACKGROUND: While Roux-en-Y hepaticojejunostomy (RYH) is the common anastomotic technique for liver transplantation (LT) in @entity0 with @entity2 ( @entity2 ), @entity3 ( @entity3 ) reconstruction may be used if the recipient common bile duct is normal. There are conflicting observational data on the rate of success of @entity3 reconstruction versus RYH, in @entity2 . OBJECTIVES: The aim of this study was to assess the safety and efficacy of @entity3 @entity1 , compared to RYH reconstruction, among adults transplanted for @entity2 . @entity0 AND METHODS: All adult @entity0 , who underwent primary LT for @entity2 between 1990 and 2012, were evaluated, according to type of biliary reconstruction. Recipient and graft survival, postoperative medical and surgical complications, and postoperative resource utilization rates were compared between the two groups. RESULTS: Totally, 73 @entity0 fulfilled the inclusion criteria. Of them, 58 had RYH and 15 had @entity3 reconstruction. A total of 53 subjects (73%) were male, with the mean age    standard deviation at LT of 43.3    14.4 years. Rates of recipient mortality, graft failure, biliary complications, acute cellular rejection, and reoperation were similar in both groups. Postoperative cholangiography was used more frequently in @entity0 with @entity3 reconstruction (33.3% vs. 8.6%, P = 0.026). CONCLUSIONS: In selected recipients with @entity2 , @entity3 reconstruction is a safe and efficacious technique, with long-term clinical outcomes comparable to RYH.

title: Duct-to-Duct Biliary Anastomosis Yields Similar Outcomes to Roux-en-Y Hepaticojejunostomy in Liver Transplantation for XXXX .

answer: @entity2


abstract: PURPOSE: To assess the long-term results of a homemade aortomonoiliac @entity3 ( @entity3 ) device used for endovascular @entity4 ( @entity4 ) repair. METHODS: A vascular audit database was interrogated to identify 58 consecutive @entity4 @entity0 (all @entity0 ; median age 73 years, range 56-88) who underwent aortomonoiliac stent-graft repair. AAAs were eligible for endovascular treatment if the infrarenal neck was > or = 15 mm long and < or = 28 mm in diameter. RESULTS: Nine (15.5%) procedures failed, 8 during the procedure and 1 on the 7th postoperative day; 8(13.8%) @entity0 were converted, but one was unfit for surgery. There was one intraprocedural @entity1 , and 3 (5.2%) @entity0 died within 30 days. The primary success rate (no conversion or mortality) was 79.3%. Over a median follow-up of 45 months (range 23-80), there were 3 (5.2%) graft occlusions, 1 kink requiring stent implantation, and 1 expanding sac without identifiable @entity5 . There were 11 (19.0%) endoleaks in 10 @entity0 , 9 type I leaks (2 proximal) and 1 type II. One @entity0 with a distal type I @entity5 (treated) also exhibited a type III leak at 2 years, but the sac size had not increased. There was a 40% incidence of @entity2 , which was serious in only 1 @entity0 . The long-term survival rate by Kaplan-Meier life-table analysis was 57% at 4 years. CONCLUSIONS: Implantation of an aortomonoiliac PTFE device can be achieved with good primary success, and the stent-graft seems durable over the long term. Proximal type I endoleaks are rare, but distal endoleaks from the contralateral common iliac artery can be solved by using a different covered stent.

title: Long-term results of XXXX repair using a homemade aortomonoiliac PTFE device.

answer: @entity4


abstract: MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs, which play a critical role in regulating varieties of the biological and pathologic processes. MiR-196a has been reported to take part in tumorigenic progression of @entity2 ( @entity2 ). However, the effects of miR-196a on @entity2 are still unclear. The objective of this study is to investigate the molecular mechanism of miR-196a in @entity2 cells. In the present study, the expression of miR-196a in @entity2 cell lines was detected by real-time PCR. We found that the expression level of miR-196a was markedly up-regulated in @entity2 cell lines compared with normal osteoblastic cells. Then, the miR-196a mimic was transiently transfected into MG63 and @entity0 cells using @entity3 reagent. Subsequently, the @entity1 and Brdu-ELISA results showed that up-regulation of miR-196a promoted the cell viability and proliferation. Our results also showed that miR-196a mimic accelerated cell cycle progression of MG63 and @entity0 cells by down regulation of @entity8 and @entity10 , and upregulation of @entity9 . In addition, overexpression of miR-196a suppressed apoptosis of MG63 and @entity0 cells due to increasing @entity11 and @entity7 expressions, and then inactivating @entity4 . Eventually, the effect of miR-196a mimic on the @entity12 ( @entity12 )/ @entity5 signaling pathway was explored by Western blot. From our results, transfection of miR-196a decreased the expression of @entity6 and increased the phosphorylation of @entity12 and @entity5 . Taken together, miR-196a should be an oncogene in @entity2 . The possible mechanism was that overexpression of miR-196a promoted proliferation of MG63 and @entity0 cells by modulating the @entity6 / @entity12 / @entity5 signaling pathway.

title: MicroRNA-196a overexpression promotes cell proliferation and inhibits cell apoptosis through XXXX / @entity5 /FOXO1 pathway.

answer: @entity6


abstract: MicroRNAs (miRNAs) are endogenous, non-coding, small RNAs, which play a critical role in regulating varieties of the biological and pathologic processes. MiR-196a has been reported to take part in tumorigenic progression of @entity2 ( @entity2 ). However, the effects of miR-196a on @entity2 are still unclear. The objective of this study is to investigate the molecular mechanism of miR-196a in @entity2 cells. In the present study, the expression of miR-196a in @entity2 cell lines was detected by real-time PCR. We found that the expression level of miR-196a was markedly up-regulated in @entity2 cell lines compared with normal osteoblastic cells. Then, the miR-196a mimic was transiently transfected into MG63 and @entity0 cells using @entity3 reagent. Subsequently, the @entity1 and Brdu-ELISA results showed that up-regulation of miR-196a promoted the cell viability and proliferation. Our results also showed that miR-196a mimic accelerated cell cycle progression of MG63 and @entity0 cells by down regulation of @entity8 and @entity10 , and upregulation of @entity9 . In addition, overexpression of miR-196a suppressed apoptosis of MG63 and @entity0 cells due to increasing @entity11 and @entity7 expressions, and then inactivating @entity4 . Eventually, the effect of miR-196a mimic on the @entity12 ( @entity12 )/ @entity5 signaling pathway was explored by Western blot. From our results, transfection of miR-196a decreased the expression of @entity6 and increased the phosphorylation of @entity12 and @entity5 . Taken together, miR-196a should be an oncogene in @entity2 . The possible mechanism was that overexpression of miR-196a promoted proliferation of MG63 and @entity0 cells by modulating the @entity6 / @entity12 / @entity5 signaling pathway.

title: MicroRNA-196a overexpression promotes cell proliferation and inhibits cell apoptosis through @entity6 / XXXX /FOXO1 pathway.

answer: @entity5


abstract: PURPOSE: To report the complication of @entity6 after laser photocoagulation and pars plana vitrectomy ( @entity4 ) for @entity2 (ROP). METHODS: A retrospective chart review of @entity0 treated for ROP with plus disease between 2004 and 2013 at University Hospital, Newark, New Jersey. RESULTS: Of the 110 eyes (55 @entity0 ) that underwent treatment for ROP, 8 (7.27%) eyes were noted to develop @entity6 in 4 neonates (4 eyes after laser photocoagulation and 4 eyes after @entity4 ). All 8 eyes that developed ulcerative keratitis had a preceding corneal @entity5 followed by corneal stromal haze. Seven of 8 eyes developed @entity5 within 8 days of the procedure. All epithelial defects progressed to ulcerative keratitis within 7 days. A total of 10 (9.1%) eyes developed @entity1 , and 8 (80%) of these eyes were ultimately diagnosed as having ulcerative keratitis. Four (4.08%) of 98 eyes treated with laser photocoagulation alone developed infective ulcerative keratitis, compared to 4 (33.33%) of 12 eyes treated with @entity4 . Because @entity3 healed, corneal opacification ensued and covered 10% to 90% of the corneal surface area. Five of the 8 eyes had positive culture of corneal scrapings: 2 grew coagulase-negative Staphylococcus and Stenotrophamonas; 1 grew coagulase-negative Staphylococcus; 1 grew @entity7 viridans, and 1 grew Staphylococcus hominis, @entity7 , and @entity7 viridans. All 8 eyes were treated with antibiotic eye drops. CONCLUSIONS: Infectious ulcerative keratitis developed in a small, but significant, percentage of @entity0 undergoing treatment for ROP. Postoperative corneal epithelial defects with subsequent corneal haze appear to be involved in the progression to ulcerative keratitis.

title: Infectious Ulcerative Keratitis Following XXXX Treatment.

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: We have recently published an overview and meta-analysis of the effects of the five major classes of blood pressure-lowering drugs on cardiovascular outcomes when compared with placebo. However, possible differences in effectiveness of the various classes can correctly be estimated only by head-to-head comparisons of different classes of agents. This has been the objective of a new survey and meta-analysis. METHODS: A database search between 1966 and August 2014 ide ntified 50 eligible randomized controlled trials for 58 two-drug comparisons (247006 @entity0 for 1029768 @entity0 -years). Risk ratios and their 95% confidence intervals of seven outcomes were estimated by a random-effects model. RESULTS: The effects of all drug classes are not significantly different on most outcomes when their blood pressure effect is equivalent. However, there are also significant differences involving almost all classes of drugs. When compared to all other classes together, diuretics are superior in preventing @entity5 ; beta-blockers less effective in preventing @entity1 ; @entity4 antagonists superior in preventing @entity1 and all-cause death, but inferior in preventing @entity5 ; angiotensin-converting enzyme inhibitors more effective in preventing @entity3 and less in preventing @entity1 ; angiotensin receptor blockers inferior in preventing @entity3 ; and @entity6 -angiotensin system blockers more effective in preventing @entity5 . When stratifying randomized controlled trials according to total cardiovascular risk, no drug class was found to change in effectiveness with the level of risk. CONCLUSIONS: The results of all available evidence from head-to-head drug class comparisons do not allow the formulation of a fixed paradigm of drug choice valuable for all @entity2 @entity0 , but the differences found may suggest specific choices in specific conditions, or preferable combinations of drugs.

title: Effects of blood pressure-lowering on outcome incidence in XXXX : 5. Head-to-head comparisons of various classes of antihypertensive drugs - overview and meta-analyses.

answer: @entity2


abstract: @entity4 ( @entity4 ) holoenzyme is anchored to specific subcellular regions by interactions between regulatory subunits ( @entity4 -R) and A-kinase anchoring proteins (AKAPs). We examine the functional importance of @entity4 anchoring during @entity0 oogenesis by analyzing membrane integrity and actin structures in mutants with disruptions in @entity5 , an @entity6 . In wild-type ovaries, @entity4 and @entity5 localized to membranes and to the outer rim of ring canals, actin-rich structures that connect germline cells. In @entity5 mutant ovaries, @entity4 membrane localization decreased, leading to a destabilization of membrane structures and the formation of binucleate nurse cells. Defects in membrane integrity could be mimicked by expressing a constitutively active @entity2 ( @entity2 ) throughout germline cells. Unexpectedly, nurse cells in @entity5 mutant ovaries also had enlarged, thin ring canals. In contrast, overexpressing @entity5 in the germline resulted in thicker, smaller ring canals. To investigate the role of @entity5 in regulating ring canal growth, we examined genetic interactions with other genes that are known to regulate ring canal morphology. @entity5 mutations suppressed the small ring canal phenotype produced by @entity3 mutants, linking @entity5 with the non-receptor @entity1 kinase pathway. Together, these results provide the first evidence that @entity4 localization is required for morphogenesis of actin structures in an intact organism.

title: An XXXX is required for @entity4 regulatory subunit localization and morphology of actin structures during oogenesis in @entity0 .

answer: @entity6


abstract: @entity4 ( @entity4 ) holoenzyme is anchored to specific subcellular regions by interactions between regulatory subunits ( @entity4 -R) and A-kinase anchoring proteins (AKAPs). We examine the functional importance of @entity4 anchoring during @entity0 oogenesis by analyzing membrane integrity and actin structures in mutants with disruptions in @entity5 , an @entity6 . In wild-type ovaries, @entity4 and @entity5 localized to membranes and to the outer rim of ring canals, actin-rich structures that connect germline cells. In @entity5 mutant ovaries, @entity4 membrane localization decreased, leading to a destabilization of membrane structures and the formation of binucleate nurse cells. Defects in membrane integrity could be mimicked by expressing a constitutively active @entity2 ( @entity2 ) throughout germline cells. Unexpectedly, nurse cells in @entity5 mutant ovaries also had enlarged, thin ring canals. In contrast, overexpressing @entity5 in the germline resulted in thicker, smaller ring canals. To investigate the role of @entity5 in regulating ring canal growth, we examined genetic interactions with other genes that are known to regulate ring canal morphology. @entity5 mutations suppressed the small ring canal phenotype produced by @entity3 mutants, linking @entity5 with the non-receptor @entity1 kinase pathway. Together, these results provide the first evidence that @entity4 localization is required for morphogenesis of actin structures in an intact organism.

title: An @entity6 is required for XXXX regulatory subunit localization and morphology of actin structures during oogenesis in @entity0 .

answer: @entity4


abstract: @entity4 ( @entity4 ) holoenzyme is anchored to specific subcellular regions by interactions between regulatory subunits ( @entity4 -R) and A-kinase anchoring proteins (AKAPs). We examine the functional importance of @entity4 anchoring during @entity0 oogenesis by analyzing membrane integrity and actin structures in mutants with disruptions in @entity5 , an @entity6 . In wild-type ovaries, @entity4 and @entity5 localized to membranes and to the outer rim of ring canals, actin-rich structures that connect germline cells. In @entity5 mutant ovaries, @entity4 membrane localization decreased, leading to a destabilization of membrane structures and the formation of binucleate nurse cells. Defects in membrane integrity could be mimicked by expressing a constitutively active @entity2 ( @entity2 ) throughout germline cells. Unexpectedly, nurse cells in @entity5 mutant ovaries also had enlarged, thin ring canals. In contrast, overexpressing @entity5 in the germline resulted in thicker, smaller ring canals. To investigate the role of @entity5 in regulating ring canal growth, we examined genetic interactions with other genes that are known to regulate ring canal morphology. @entity5 mutations suppressed the small ring canal phenotype produced by @entity3 mutants, linking @entity5 with the non-receptor @entity1 kinase pathway. Together, these results provide the first evidence that @entity4 localization is required for morphogenesis of actin structures in an intact organism.

title: An @entity6 is required for @entity4 regulatory subunit localization and morphology of actin structures during oogenesis in XXXX .

answer: @entity0


abstract: UNASSIGNED: to determine the principal @entity2 for which @entity0 underwent surgery and to determine the survival rate. this retrospective cohort study involves Congolese babies treated surgically from September 1989 to September 2010 in France for @entity10 (through "M  c  nat chirurgie cardiaque" and "Cha  ne de l'espoir"). It includes only 110 of the 182 recorded @entity0 during the study period. The sex ratio for the 110 subjects included in the analysis was 1. Their mean age at surgery was 77.4      57.6 months old (range: 8 to 204 months). The main @entity10 for which surgery was performed were @entity9 (21.9%), tetralogy of Fallot either isolated (22.8%) or associated with @entity11 (1.8%) or @entity3 (1.8%), @entity1 associated with other @entity6 (8.2%), @entity8 with @entity9 (5.5%), @entity4 (3.7%), @entity5 (0.9%), and @entity7 (0.9%). The median length of follow-up was 42.4      35.6 months (range, 3-240 months). @entity0 ' mean age at the study's end was 121.1      86.3 months (range 20-372 months). The 5-year survival rate was 90% and the 20-year survival, 83.3%. Heart surgery for @entity10 has improved survival.

title: Epidemiology and outcome of Congolese @entity0 who had surgery for XXXX .

answer: @entity2


abstract: UNASSIGNED: to determine the principal @entity2 for which @entity0 underwent surgery and to determine the survival rate. this retrospective cohort study involves Congolese babies treated surgically from September 1989 to September 2010 in France for @entity10 (through "M  c  nat chirurgie cardiaque" and "Cha  ne de l'espoir"). It includes only 110 of the 182 recorded @entity0 during the study period. The sex ratio for the 110 subjects included in the analysis was 1. Their mean age at surgery was 77.4      57.6 months old (range: 8 to 204 months). The main @entity10 for which surgery was performed were @entity9 (21.9%), tetralogy of Fallot either isolated (22.8%) or associated with @entity11 (1.8%) or @entity3 (1.8%), @entity1 associated with other @entity6 (8.2%), @entity8 with @entity9 (5.5%), @entity4 (3.7%), @entity5 (0.9%), and @entity7 (0.9%). The median length of follow-up was 42.4      35.6 months (range, 3-240 months). @entity0 ' mean age at the study's end was 121.1      86.3 months (range 20-372 months). The 5-year survival rate was 90% and the 20-year survival, 83.3%. Heart surgery for @entity10 has improved survival.

title: Epidemiology and outcome of Congolese XXXX who had surgery for @entity2 .

answer: @entity0


abstract: Fibroblast growth factors (FGFs) comprise a family of polypeptide growth factors implicated in the control of proliferation of glandular tissues. The aim of this study was to determine whether FGFs are produced in normal and abnormal parathyroid glands and if these tissues have the potential to respond to this growth factor family. We have examined the expression of @entity10 (FGF-R) types 1 and 2 and of @entity14 , and 7 in a series of @entity0 parathyroid tissues using the reverse transcription polymerase chain reaction (RT-PCR). Samples of 10 @entity6 and 10 @entity7 glands from @entity0 with @entity1 ( @entity5 ) were compared with samples from normal parathyroid glands from @entity0 with primary @entity5 in the study. @entity9 was expressed in all samples and @entity10 in most. @entity8 and @entity3 were expressed in all samples at variable levels, with no correlation between disease type and amplified RT-PCR product levels. @entity13 was expressed in normal parathyroid tissue and in all @entity4 but was absent in all but one of the @entity6 glands from @entity2 @entity0 . @entity12 was expressed at low levels in normal tissue and variably expressed in diseased tissue, in some instances at high levels. These findings suggest that parathyroid tissue is potentially responsive to FGFs. The absence of @entity13 expression in all but one of the renal parathyroid samples compared with normal and adenomatous tissue requires further investigation. The presence of elevated levels of @entity12 expression in abnormal parathyroid tissue may be significant, as the @entity12 gene ( @entity12 proto-oncogene) is located on chromosome 11q13.3, a region already identified as being susceptible to rearrangement/mutation in @entity11 .

title: Fibroblast growth factors and their receptors in XXXX .

answer: @entity11


abstract: The chlorophyll-b-less chlorina-f2 @entity3 mutant is deficient in the major as well as some minor light-harvesting chlorophyll-protein complexes of photosystem II (LHCII). Although the @entity2 had relatively minor repercussions on the leaf photosynthetic performances, the responses of photosystem II (PSII) to elevated temperatures and to bright light were markedly modified. The chlorina-f2 mutation noticeably reduced the thermostability of PSII, with thermal denaturation of PSII starting at about 35[deg]C and 38.5[deg]C in chlorina-f2 and in the wild type, respectively. The increased susceptibility of PSII to @entity4 in chlorina-f2 leaves was due to the weakness of its electron donor side, with moderate @entity4 causing detachment of the 33-kD extrinsic PSII protein from the @entity0 -evolving complex. Prolonged dark adaptation of chlorina-f2 leaves was also observed to inhibit the PSII donor side. However, @entity1 slowly reversed the dark-induced inhibition of PSII in chlorina-f2 and cancelled the difference in PSII thermostability observed between chlorina-f2 and wild-type leaves. The mutant was more sensitive to photoinhibition than the wild type, with strong light stress impairing the PSII donor side in chlorina-f2 but not in the wild type. This difference was not observed in anaerobiosis or in the presence of @entity5 , @entity5 . The acceptor side of PSII was only slightly affected by the mutation and/or the aforementioned stress conditions. Taken together, our results indicate that LHCII stabilize the PSII complexes and maintain the water-oxidizing system in a functional state under varying environmental conditions.

title: Thermostability and Photostability of Photosystem II in Leaves of the Chlorina-f2 XXXX Mutant Deficient in Light-Harvesting Chlorophyll a/b Protein Complexes.

answer: @entity3


abstract: OBJECTIVE: To investigate the antitumor activity of @entity4 combined with @entity2 ( @entity5 ) on @entity3 ( @entity3 ) cell lines. METHODS: The effects of @entity4 combined with @entity5 on the viability of @entity0 and caki-2 cell lines were evaluated by @entity1 assay. The inhibitory effect of combination of the two drugs was analyzed by the Chou and Talalay method. Flow cytometry was employed to analyze cell cycle and cell apoptosis. RESULTS: @entity1 assay showed that both @entity4 and @entity5 decreased @entity0 and Caki-2 cells viability in a dose-dependent and time-dependent manner. In @entity0 cells, @entity4 combined with @entity5 had a synergistic inhibitory effect (CI < 1) when the inhibition effect was >=  0.3. In Caki-2 cells, @entity4 combined with @entity5 had a synergistic inhibitory effect (CI < 1) when the inhibition effect was >=  0.4. @entity4 and @entity5 combination elicited significant apoptosis compared to drug used alone (P < 0.05). Furthermore, @entity4 and @entity5 acted synergistically to arrest @entity0 and Caki-2 cells in G0/G1 phase. CONCLUSION: We highlighted for the first time that @entity4 combined with @entity5 could significantly increase anti-ccRCC effect through synergetic effect; its possible mechanisms were inducing apoptosis and adjusting cell cycle.

title: Combination of @entity4 and @entity2 synergistically induces cell cycle arrest and apoptosis in XXXX .

answer: @entity3


abstract: OBJECTIVE: To investigate the antitumor activity of @entity4 combined with @entity2 ( @entity5 ) on @entity3 ( @entity3 ) cell lines. METHODS: The effects of @entity4 combined with @entity5 on the viability of @entity0 and caki-2 cell lines were evaluated by @entity1 assay. The inhibitory effect of combination of the two drugs was analyzed by the Chou and Talalay method. Flow cytometry was employed to analyze cell cycle and cell apoptosis. RESULTS: @entity1 assay showed that both @entity4 and @entity5 decreased @entity0 and Caki-2 cells viability in a dose-dependent and time-dependent manner. In @entity0 cells, @entity4 combined with @entity5 had a synergistic inhibitory effect (CI < 1) when the inhibition effect was >=  0.3. In Caki-2 cells, @entity4 combined with @entity5 had a synergistic inhibitory effect (CI < 1) when the inhibition effect was >=  0.4. @entity4 and @entity5 combination elicited significant apoptosis compared to drug used alone (P < 0.05). Furthermore, @entity4 and @entity5 acted synergistically to arrest @entity0 and Caki-2 cells in G0/G1 phase. CONCLUSION: We highlighted for the first time that @entity4 combined with @entity5 could significantly increase anti-ccRCC effect through synergetic effect; its possible mechanisms were inducing apoptosis and adjusting cell cycle.

title: Combination of @entity4 and XXXX synergistically induces cell cycle arrest and apoptosis in @entity3 .

answer: @entity2


abstract: OBJECTIVE: To investigate the antitumor activity of @entity4 combined with @entity2 ( @entity5 ) on @entity3 ( @entity3 ) cell lines. METHODS: The effects of @entity4 combined with @entity5 on the viability of @entity0 and caki-2 cell lines were evaluated by @entity1 assay. The inhibitory effect of combination of the two drugs was analyzed by the Chou and Talalay method. Flow cytometry was employed to analyze cell cycle and cell apoptosis. RESULTS: @entity1 assay showed that both @entity4 and @entity5 decreased @entity0 and Caki-2 cells viability in a dose-dependent and time-dependent manner. In @entity0 cells, @entity4 combined with @entity5 had a synergistic inhibitory effect (CI < 1) when the inhibition effect was >=  0.3. In Caki-2 cells, @entity4 combined with @entity5 had a synergistic inhibitory effect (CI < 1) when the inhibition effect was >=  0.4. @entity4 and @entity5 combination elicited significant apoptosis compared to drug used alone (P < 0.05). Furthermore, @entity4 and @entity5 acted synergistically to arrest @entity0 and Caki-2 cells in G0/G1 phase. CONCLUSION: We highlighted for the first time that @entity4 combined with @entity5 could significantly increase anti-ccRCC effect through synergetic effect; its possible mechanisms were inducing apoptosis and adjusting cell cycle.

title: Combination of XXXX and @entity2 synergistically induces cell cycle arrest and apoptosis in @entity3 .

answer: @entity4


abstract: PURPOSE: The aim of this study is to determine the feasibility and effectiveness of a novel injectable Porous Surface Modified Bioactive Bone Cement (PSMBBC) for vertebroplasty of aiding osteoporotic vertebrae in an @entity1 model. METHODS: 72 @entity1 @entity0 were randomly divided into three groups: the @entity2 ( @entity2 ) group, the PSMBBC group and the control group. @entity2 and PSMBBC were administrated to osteoporotic vertebrae in vertebroplasty, respectively. The animals were sacrificed at 1w, 4w, 12w after the procedure. Micro-CT analysis, biomechanical tests and histological analysis were performed at each time point. RESULTS: From 4 to 12 weeks after the implantation of bone cements, the bone volume fraction (BV/TV) of the PSMBBC group increased from 28.27    1.69% to 38.43    1.34%. However, the BV/TV of the @entity2 group showed no significant difference after the implantation. At 4 weeks, direct contact between the bone and the bone cement was observed in the PSMBBC group. At 12 weeks, it was discovered that new intact bone trabecular was formed in PSMBBC group. Furthermore, the maximum compressive strength values of the PSMBBC group were significantly higher than those of the control group at each time point after implantation. CONCLUSIONS: In summary, this study was the first investigation to evaluate the potential application of PSMBBC for vertebroplasty. RESULTS demonstrated its beneficial effects on the trabecular ingrowth of new bone and bone mineral density increase. With further validation, PSMBBC can become a valuable biomaterial for aiding osteoporotic vertebrae and usable bone cement applied in vertebroplasty.

title: A novel injectable porous surface modified bioactive bone cement for vertebroplasty: an in vivo biomechanical and osteogenic study in a @entity0 XXXX model.

answer: @entity1


abstract: PURPOSE: The aim of this study is to determine the feasibility and effectiveness of a novel injectable Porous Surface Modified Bioactive Bone Cement (PSMBBC) for vertebroplasty of aiding osteoporotic vertebrae in an @entity1 model. METHODS: 72 @entity1 @entity0 were randomly divided into three groups: the @entity2 ( @entity2 ) group, the PSMBBC group and the control group. @entity2 and PSMBBC were administrated to osteoporotic vertebrae in vertebroplasty, respectively. The animals were sacrificed at 1w, 4w, 12w after the procedure. Micro-CT analysis, biomechanical tests and histological analysis were performed at each time point. RESULTS: From 4 to 12 weeks after the implantation of bone cements, the bone volume fraction (BV/TV) of the PSMBBC group increased from 28.27    1.69% to 38.43    1.34%. However, the BV/TV of the @entity2 group showed no significant difference after the implantation. At 4 weeks, direct contact between the bone and the bone cement was observed in the PSMBBC group. At 12 weeks, it was discovered that new intact bone trabecular was formed in PSMBBC group. Furthermore, the maximum compressive strength values of the PSMBBC group were significantly higher than those of the control group at each time point after implantation. CONCLUSIONS: In summary, this study was the first investigation to evaluate the potential application of PSMBBC for vertebroplasty. RESULTS demonstrated its beneficial effects on the trabecular ingrowth of new bone and bone mineral density increase. With further validation, PSMBBC can become a valuable biomaterial for aiding osteoporotic vertebrae and usable bone cement applied in vertebroplasty.

title: A novel injectable porous surface modified bioactive bone cement for vertebroplasty: an in vivo biomechanical and osteogenic study in a XXXX @entity1 model.

answer: @entity0


abstract: OBJECTIVES: @entity3 frequently occur as two or more separate foci within the thyroid gland (18%-87%). However, those multifocal @entity1 are easy to be undetected by preoperative radiologic evaluations, which lead to @entity2 after initial surgery. We aimed to study the incidence of multifocal @entity5 ( @entity5 ), diagnostic accuracy of preoperative radiologic evaluation, predictive factors, and the chance of @entity1 . METHODS: Two hundred and seventy-seven @entity0 with PTMC were included in this study. All @entity0 underwent total thyroidectomy as an initial treatment. Medical records, pathologic reports, and radiological reports were reviewed for analysis. RESULTS: Multifocal @entity5 were detected in 100 of 277 @entity0 (36.1%). The mean number of @entity1 in each @entity0 was 1.6  1.1, ranging from 1 to 10. The additional @entity1 foci were significantly smaller (0.32  0.18 cm) than the primary @entity1 (0.63  0.22 cm) (P<0.001). There was no significant relationship between @entity1 size and the presence of @entity1 . With more @entity1 detected in one lobe, there was greater chance of @entity1 ; 18.8% with @entity1 focus, 30.2% with 2 @entity1 foci, and 46.2% with 3 or more @entity1 foci in one lobe. Sensitivity of preoperative sonography was 42.7% for multifocal @entity1 and 49.0% for @entity1 . With multivariate analysis, @entity4 was the only significant factor for multifocal @entity1 . CONCLUSION: In cases of @entity5 , the incidence of multifocal @entity1 is high. However, additional @entity1 foci are too small to be diagnosed preoperatively, especially under the recent guidelines on radiologic screening tests for @entity3 . Multifocal @entity5 have high risk of @entity1 , necessitating more extensive surgery or more thorough follow-up.

title: Multifocality and bilaterality of XXXX .

answer: @entity5


abstract: OBJECTIVES: To determine the feasibility of routinely performing internal urethrotomy for @entity3 under intracorpus spongiosum anesthesia in an outpatient setting. METHODS: In a consecutive series of 23 @entity0 with @entity3 , a dosage of 3 mL of 1% @entity2 was slowly injected into the glans penis. Next, optical urethrotomy was performed immediately with a cold-cutting knife. The effect of this anesthetic technique was evaluated by questionnaire. RESULTS: Internal urethrotomy was successfully completed in all the @entity0 . Twenty-two @entity0 (95.7%) had no @entity1 or discomfort. One @entity0 reported minimal but tolerable discomfort while the tissue above the stricture was being cut. The anesthesia lasted for about 1.5 hours and was very satisfactory without any complications. CONCLUSIONS: Under intracorpus spongiosum anesthesia, optical urethrotomy can be routinely performed in an outpatient setting. With this new local anesthesia, internal urethrotomy is a safe, effective, simple, and inexpensive procedure for treatment of @entity3 .

title: Optical urethrotomy for XXXX under a new local anesthesia: intracorpus spongiosum anesthesia.

answer: @entity3


abstract: BACKGROUND: Growth in @entity0 with @entity4 ( @entity4 ) differs markedly from that of normal @entity0 . The use of @entity4 specific growth charts is important for diagnosis of associated diseases, such as @entity1 and @entity3 , which may further impair growth. AIMS: To present Swedish @entity4 specific growth charts. METHODS: The growth charts are based on a combination of longitudinal and cross sectional data from 4832 examinations of 354 individuals with @entity4 (203 males, 151 females), born in 1970-97. RESULTS: Mean birth length was 48 cm in both sexes. Final height, 161.5 cm for males and 147.5 cm for females, was reached at relatively young ages, 16 and 15 years, respectively. Mean birth weight was 3.0 kg for @entity0 and 2.9 kg for @entity0 . A body mass index (BMI) >25 kg/m(2) at 18 years of age was observed in 31% of the males and 36% of the females. Head growth was impaired, resulting in a SDS for head circumference of -0.5 (Swedish standard) at birth decreasing to -2.0 at 4 years of age. CONCLUSION: Despite @entity2 the difference in height between the sexes is the same as that found in healthy individuals. Even though puberty appears somewhat early, the charts show that @entity4 individuals have a decreased pubertal growth rate. Our growth charts show that European @entity0 with @entity4 are taller than corresponding American @entity0 , whereas European @entity0 with @entity4 , although being lighter, have similar height to corresponding American @entity0 .

title: Growth charts for XXXX from birth to 18 years of age.

answer: @entity4


abstract: OBJECTIVES: The boundary where inner and outer enamel epithelia meet is referred to as the cervical loop (CL) in molar tooth germs. In contrast, rodent incisors are continuously growing: the labial side of the teeth is covered with enamel (crown-analog), and the lingual side is covered with cementum (root-analog). These results in the appearance of CL in the frontal sections apart from the apical end. However, many researchers have used the term "labial CL" to indicate the apical end of incisors. DESIGN: This study investigated the gene expression patterns for the enamel knot signaling center in tooth morphogenesis to clarify the difference between "labial CL" and molar CL. We examined the three-dimensional expression patterns of markers for the enamel knot including @entity3 ( @entity3 ), sonic hedgehog ( @entity2 ), @entity4 , and @entity1 in frontal sections of @entity0 mandibular incisors. RESULTS: Serial frontal sections from the apical end of the postnatal incisor clearly demonstrated the existence of enamel knot-like structures composed of supra-inner enamel epithelium and stellate reticulum in the "labial CL". This structure includes the expression of all examined markers for enamel knots such as @entity3 , @entity2 , @entity4 , and @entity1 . CONCLUSIONS: The molar tooth germ-like structure is maintained indefinitely in the "labial CL". Therefore, the "labial CL" is not equivalent to the molar CL. The existence of an EK-like structure in the apical end of incisors implies that the usage of "labial CL" may be inappropriate for indicating this region. The "apical bud" could be used as an alternative term.

title: The enamel knot-like structure is eternally maintained in the apical bud of postnatal XXXX incisors.

answer: @entity0


abstract: Understanding neuronal network function requires multi-site recording. An optical imaging method using @entity2 ( @entity2 ) is one such suitable method. It is also important to complement this technique with methods that measure other physiological parameters of neuronal network activity. We aimed to develop a multi-channel electrode method that would easily permit the simultaneous optical imaging of neural activity in vitro. There are several multi-electrode systems; some of these are commercially available, but they are not easy to use and are also expensive. We developed a novel, less expensive, stainless steel inline electrode array that utilizes the standard etching method of circuit board manufacturing. This method, along with widely available computer drawing software, allowed us to produce electrode arrays with uniform quality in electrical characteristics and shapes. The electrode array was designed so that it could easily substitute for single electrode systems without modifying the conventional set-up used for electrophysiological measurements and optical recordings. Simultaneous measurement of evoked neural activities in area @entity1 of the @entity0 hippocampal slice with our optical imaging method using the @entity2 Di-4-ANEPPS is demonstrated in this paper. The electrode array was also used as a stimulating electrode, and the evoked response was measured by the optical recording method. The results demonstrate the advantages of simultaneous recordings obtained by these complementary multi-site recording methods in vitro.

title: Simultaneous multi-site recordings of neural activity with an inline multi-electrode array and optical measurement in XXXX hippocampal slices.

answer: @entity0


abstract: OBJECTIVE: To summarize short-term results of video-assisted thoracic surgery for 322 @entity0 with @entity7 in Beijing from October 1992 to October 1998 and discuss the role of thoracoscopy in the diagnosis and therapy of @entity8 in China. METHODS: Three hundred and twenty-two @entity0 (273 @entity0 and 85 @entity0 ) underwent video-assisted thoracic surgery for spontaneous pneumothorax (113), @entity1 (83), solitary pulmonary nodules (52), @entity6 (19), mediastinal @entity2 (11), @entity9 (5), @entity3 (10), @entity5 (7), benign esophageal diseases (11), and other indications (11). Data on thoracoscopic procedures, morbidity and mortality, conversion to open procedures were collected for all @entity0 . RESULTS: Three hundred and thirty-nine thoracoscopic procedures were performed in 322 @entity0 . These procedures included blebectomy and pleurodesis (121), wedge resections of pulmonary nodules (57), lobectomy and pneumonectomy (48), pleural biopsies and pleurodesis (52), excision of mediastinal mass (11), thymectomy (5), esophagectomy (6), and other procedures (39). Conversion to thoracotomy was required in 9 @entity0 (0.28%). The overall incidence of @entity4 was 7.5% (24/322). Two @entity0 died postoperatively. CONCLUSIONS: Video-assisted thoracic surgery is a safe and effective technique in selected @entity0 with @entity7 . The results in this group were similar to those reported previously in North American.

title: [Video-assisted thoracic surgery in the management of XXXX ].

answer: @entity7


abstract: BACKGROUND: Several recent studies have identified that the @entity9 genetic polymorphism @entity11 is associated with @entity2 risk, but presented inconsistent results. We investigated these inconclusive results by performing a meta-analysis to systematically evaluate the association. METHODS: We conducted a search in PubMed, Google Scholar and ISI Web of Science to select studies on the association between @entity9 @entity11 and @entity2 risk. We conducted a stratified analysis using @entity2 type, ethnicity and source of controls. We calculated the odds ratios (OR) and 95% confidence intervals (CI). Article quality, heterogeneity, sensitivity, publication bias and statistical power were also assessed. RESULTS: 26 articles covering 76 108 cases and 134 215 controls met our inclusion criteria. A significant association between @entity9 @entity11 allele A and @entity2 susceptibility was demonstrated under a per-allele risk analysis (OR = 1.08, 95% CI = 1.04-1.13). Stratification analysis revealed an increased @entity2 risk in subgroups of @entity3 , @entity1 and @entity5 . No significant increase was found in @entity6 , @entity0 , @entity8 and @entity4 . In a subgroup analysis of @entity1 , a statistically significant increase was only observed in @entity7 . Moreover, a stratified analysis performed for ethnic groups revealed that the significant increase was only observed in Caucasians, whereas a non-significant increase was found in Asians. CONCLUSIONS: This meta-analysis suggests that the @entity9 genetic polymorphism @entity11 is associated with increased risk of @entity3 , @entity10 and @entity5 among Caucasians. Further functional studies are warranted to validate this association and investigate further.

title: Association between the @entity9 Genetic Polymorphism XXXX and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls.

answer: @entity11


abstract: BACKGROUND: Several recent studies have identified that the @entity9 genetic polymorphism @entity11 is associated with @entity2 risk, but presented inconsistent results. We investigated these inconclusive results by performing a meta-analysis to systematically evaluate the association. METHODS: We conducted a search in PubMed, Google Scholar and ISI Web of Science to select studies on the association between @entity9 @entity11 and @entity2 risk. We conducted a stratified analysis using @entity2 type, ethnicity and source of controls. We calculated the odds ratios (OR) and 95% confidence intervals (CI). Article quality, heterogeneity, sensitivity, publication bias and statistical power were also assessed. RESULTS: 26 articles covering 76 108 cases and 134 215 controls met our inclusion criteria. A significant association between @entity9 @entity11 allele A and @entity2 susceptibility was demonstrated under a per-allele risk analysis (OR = 1.08, 95% CI = 1.04-1.13). Stratification analysis revealed an increased @entity2 risk in subgroups of @entity3 , @entity1 and @entity5 . No significant increase was found in @entity6 , @entity0 , @entity8 and @entity4 . In a subgroup analysis of @entity1 , a statistically significant increase was only observed in @entity7 . Moreover, a stratified analysis performed for ethnic groups revealed that the significant increase was only observed in Caucasians, whereas a non-significant increase was found in Asians. CONCLUSIONS: This meta-analysis suggests that the @entity9 genetic polymorphism @entity11 is associated with increased risk of @entity3 , @entity10 and @entity5 among Caucasians. Further functional studies are warranted to validate this association and investigate further.

title: Association between the XXXX Genetic Polymorphism @entity11 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls.

answer: @entity9


abstract: OBJECTIVE: To investigate the effects of intravenous injection of defibrinogenase on dissoliving dissolve @entity4 and salvaging @entity2 in @entity1 -prone @entity7 @entity0 (RHRSP) with @entity6 (MCAO). METHODS: The MCAO in RHRSP was induced by administration in photosensitive dye, rose bengal, and irradiation of the main MCA with a focus laser beam. The @entity4 in MCA and @entity2 were examined microscopically in HE stained sections. @entity5 size was determined in @entity8 stained sections. Defibrinogenase was injected intravenously at 3, 6, 9, 12 hours and 3, 7 days after MCAO, meanwhile the control group received normal saline. All @entity0 were killed at 72 hours and evaluated by pathological methods after treatment. RESULTS: In the treatment group, the thrombi were dissolved totally at 3 hours after MCAO, 75% at 6 hours, 13% at 9 hours. Defibrinogenase failed to dissolve @entity4 beyond 12 hours after MCAO, just as control group. In comparison with the control group, defibrinogenase significantly reduced @entity5 size. There was no evidence of @entity3 . CONCLUSIONS: Defibrinogenase can reduce @entity5 size and dissolve @entity4 in 6 hours after MCAO without the side effect of @entity3 .

title: [Effects of defibrinogenase on photochemically induced @entity6 in XXXX -prone renovascular hypertensive @entity0 ].

answer: @entity1


abstract: OBJECTIVE: To investigate the effects of intravenous injection of defibrinogenase on dissoliving dissolve @entity4 and salvaging @entity2 in @entity1 -prone @entity7 @entity0 (RHRSP) with @entity6 (MCAO). METHODS: The MCAO in RHRSP was induced by administration in photosensitive dye, rose bengal, and irradiation of the main MCA with a focus laser beam. The @entity4 in MCA and @entity2 were examined microscopically in HE stained sections. @entity5 size was determined in @entity8 stained sections. Defibrinogenase was injected intravenously at 3, 6, 9, 12 hours and 3, 7 days after MCAO, meanwhile the control group received normal saline. All @entity0 were killed at 72 hours and evaluated by pathological methods after treatment. RESULTS: In the treatment group, the thrombi were dissolved totally at 3 hours after MCAO, 75% at 6 hours, 13% at 9 hours. Defibrinogenase failed to dissolve @entity4 beyond 12 hours after MCAO, just as control group. In comparison with the control group, defibrinogenase significantly reduced @entity5 size. There was no evidence of @entity3 . CONCLUSIONS: Defibrinogenase can reduce @entity5 size and dissolve @entity4 in 6 hours after MCAO without the side effect of @entity3 .

title: [Effects of defibrinogenase on photochemically induced XXXX in @entity1 -prone renovascular hypertensive @entity0 ].

answer: @entity6


abstract: OBJECTIVE: To investigate the effects of intravenous injection of defibrinogenase on dissoliving dissolve @entity4 and salvaging @entity2 in @entity1 -prone @entity7 @entity0 (RHRSP) with @entity6 (MCAO). METHODS: The MCAO in RHRSP was induced by administration in photosensitive dye, rose bengal, and irradiation of the main MCA with a focus laser beam. The @entity4 in MCA and @entity2 were examined microscopically in HE stained sections. @entity5 size was determined in @entity8 stained sections. Defibrinogenase was injected intravenously at 3, 6, 9, 12 hours and 3, 7 days after MCAO, meanwhile the control group received normal saline. All @entity0 were killed at 72 hours and evaluated by pathological methods after treatment. RESULTS: In the treatment group, the thrombi were dissolved totally at 3 hours after MCAO, 75% at 6 hours, 13% at 9 hours. Defibrinogenase failed to dissolve @entity4 beyond 12 hours after MCAO, just as control group. In comparison with the control group, defibrinogenase significantly reduced @entity5 size. There was no evidence of @entity3 . CONCLUSIONS: Defibrinogenase can reduce @entity5 size and dissolve @entity4 in 6 hours after MCAO without the side effect of @entity3 .

title: [Effects of defibrinogenase on photochemically induced @entity6 in @entity1 -prone renovascular hypertensive XXXX ].

answer: @entity0


abstract: OBJECTIVE: To explore the dose-response relation and the safety of @entity5 administered as a single i.v. bolus prior to the induction of anesthesia for preventing the haemodynamic response to tracheal intubation. METHODS: 1,830 @entity0 from 20 centres were randomly divided into three groups: E1 group, receiving @entity5 at a dose of 1 mg/kg; @entity6 mg/kg and E0 group, receiving 0.9% @entity4 . Heart rate, @entity1 (MAP) were measured following the induction and 1 to 10 minutes following the intubation. RESULTS: The @entity0 in the E0 group had greater HR and MAP values after anesthesia induction and tracheal intubation than the @entity0 in the E1 and E2 groups (P < 0.05-0.01). The E1 group had higher HR than the E2 group (P < 0.05-0.01). The incidence of @entity2 after intubation was higher in the E0 group (63.8%) than in the E1 group (34.7%) and the E2 group (22.6%) (P < 0.01). The proportion of hypotention and @entity3 was higher in the two treatment groups than the E0 group (P < 0.01), but no severe adverse event was observed. CONCLUSION: A 1-2 mg/kg bolus of @entity5 is effective and safe for preventing the haemodynamic response to tracheal intubation. The clinical and side-effects are all dose-related.

title: [Bolus administration of XXXX for preventing the haemodynamic response to tracheal intubation: a multicentre clinical study].

answer: @entity5


abstract: OBJECTIVE: To study quickscan (QS) in different therapeutic decision-making in 55 @entity0 with @entity1 . METHODS: Based on QS results, 30 @entity0 were treated conservatively. The disease progress and therapeutic effects were assessed by QS in every three months. Percutaneous transluminal angioplasty was performed successfully in 5 @entity0 without prior diagnostic angiography. 20 @entity0 were scheduled for surgery. Operation of eleven @entity0 was guided by information obtained from QS findings only, which was confirmed during operation. Angiography was necessary in 9 @entity0 except one to formulate a therapeutic strategy. RESULTS: The accuracy of QS was 92%(23/25). CONCLUSION: QS is of value in deciding the access route of angiography and PTA, and can replace preoperative angiography, Quickscan is time-saving, inexpensive, objective and accurate. It can be used in therapeutic decision making in @entity1 and bypass grafting.

title: [Ultrasonic angiography in therapeutic decision-making in XXXX ].

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) is the second most common @entity1 after adult kidney transplantation (KT). METHODS: We retrospectively analyzed 8 adult @entity0 who underwent KT in our center, diagnosed with @entity2 between 2001 and 2014. RESULTS: Six @entity0 were @entity0 . The median age at presentation was 43 years and the median time since transplantation was 7.3 years. Three @entity0 had previously received anti-thymocyte globulin/OKT3, and all were taking calcineurin inhibitors (CNI) at diagnosis. The monomorphic type was the most common, with diffuse large @entity3 as the origin. The most frequent presentation was fever. Four in five @entity0 had @entity2 . All @entity0 received various regimens of immunosuppression reduction (IR), with 4 converting CNI to @entity4 inhibitor (imTOR). Subsequent treatment (when needed) was chemotherapy, radiotherapy, and surgery. The maximum follow-up time was 6.7 years, with a 50% mortality rate that occurred at a median time of 3.5 months (2 died with functioning kidney). All 4 @entity0 who were in remission at the end of follow-up had CNI conversion to imTOR, and none lost the allograft. CONCLUSIONS: Despite the small number of cases, our results confirm the high @entity2 impact in overall and allograft survival. Our @entity2 type distribution is in accord with the literature. First-line @entity2 treatment is IR, but the best method is still unknown; our results may suggest a beneficial effect of CNI conversion to imTOR.

title: XXXX : A Single-Center Experience.

answer: @entity2


abstract: In a recent article we indicated that rituximab is an active and safe drug in @entity0 with chronic @entity3 . We report now the updated results of this study. Twenty-five individuals with chronic @entity3 were treated with intravenous rituximab at the dose of 375 mg/m2 once weekly for 4 weeks. Rituximab infusion-related side effects were observed in 18 @entity0 , but they were of modest intensity and did not require discontinuation of treatment. Long-term side effects included a decreased B-cell count of several months duration in most @entity0 which, however, did not translate into a significant rate of @entity2 . The overall response rate was 52%, with 7 cases showing a sustained response (6 months or longer). In 2 @entity0 with @entity1 , repeat challenge with rituximab induced a new response. In responders a significant rise in platelet concentrations was observed early during the course of treatment, usually 1 week after the first rituximab infusion. No clinical or laboratory parameter was found to predict treatment outcome. In conclusion, we confirm that rituximab can induce long-lasting responses in @entity0 with chronic @entity3 and has a favorable side effect profile. Therefore, we suggest its use in refractory @entity3 cases.

title: [Rituximab treatment of XXXX . Results of a phase II study].

answer: @entity3


abstract: OBJECTIVES: @entity3 is one of the clinical symptoms of @entity4 ( @entity4 ). The presence of @entity4 is a high risk marker of @entity2 and @entity1 . The @entity4 screening can be enhanced by the use of questionnaires. The Edinburgh Questionnaire presents in its English version better diagnostic performances compared to the Rose (WHO) Questionnaire. The aim of this study is to precise the performances of the French version of the Edinburgh Questionnaire among a population consulting general practitioners. METHODS: Four centers instructed 10 general practitioners each to the measurement of ankle pressure with a Doppler stethoscope. The physicians administrated the Questionnaire to 10 consecutive consultants in a same day, and measured the pressure on posterior tibial, dorsalis pedis and humeral arteries. With a second questionnaire they collected data concerning age, weight, height, and the presence of major risk factors. The same protocol was repeated a second day on new @entity0 . The diagnosis of @entity4 was based on an ankle-arm index lower than 0.85 for at least on limb. RESULTS: The population studied consisted of 727 subjects (351 females and 376 males). The mean age was at 58.3 +/- 16.1 years (ranging from 18 to 83.3 years). The sensitivity of the Questionnaire is at 47% (95% CI: 32.3-61.7%), the specificity at 98.8% (95% CI: 97.5-99.4%), the positive and negative predictive values are respectively at 73.3% (95% CI: 54.1-87.7%) and 94.8% (95% CI: 94.7-97.6%). Among this population of general practitioners consultants, the prevalence of a low ankle-arm index under 0.85 is at 6.7%. DISCUSSION: The French version of the Edinburgh Questionnaire maintains the very good specificity of the English version. The lower sensitivity could be explained by the choice of the gold standard, namely the ankle-arm index which includes asymptomatic @entity0 with authentic @entity4 . The use of this Questionnaire can be recommended for the screening of this disease as well as in epidemiological studies.

title: [Validation of a French translation of the Edinburgh claudication questionnaire among general practitioners' XXXX ].

answer: @entity0


abstract: @entity12 , also commonly referred to as @entity6 , occurs when the @entity5 produced by the adrenal glands is insufficient to meet the body's acute needs. The symptoms are nonspecific and can mimic other processes, such as @entity2 . @entity4 , lethargy, and fever can all be presenting signs. @entity12 can also result from @entity11 . Pituitary apoplexy usually occurs as @entity3 or @entity1 in the presence of a pre-existing @entity9 , and is a rare sequela of surgery. The symptoms of @entity11 are typically impressive and are relieved by urgent transsphenoidal decompression. @entity13 resulting from @entity11 can be treated with exogenous hormones. The case presented herein illustrates occult @entity11 that occurred after on-pump coronary artery bypass grafting. In this @entity0 , the initial signs of @entity12 were overlooked; however, once recognized, they were reduced dramatically with standard stress-dose @entity7 . A suprasellar mass with a cystic component was found on magnetic resonance imaging. The @entity3 pituitary gland was treated by transsphenoidal decompression, which relieved the @entity0 's @entity10 and 6th-nerve @entity8 .

title: Pituitary apoplexy presenting as XXXX after coronary artery bypass grafting.

answer: @entity12