abstract: OBJECTIVE: To test the hypothesis that tenidap has a structure-modifying effect in @entity0 @entity2 . DESIGN:                 <AbstractText Label="STUDY" NlmCategory="METHODS">multicenter, prospective, randomized, double blind, 1 year duration. @entity0 : primary @entity1 (ACR criteria) of the medial tibiofemoral compartment, medial joint space width > or =2mm, at least 10% of one cartilage surface of the medial compartment affected by superficial fibrillation or worse at baseline arthroscopy. STUDY MEDICATION: once daily dosage of either tenidap 40 mg, tenidap 120 mg or @entity4 20mg. STUDY ENDPOINTS: bilateral extended weight-bearing X-rays and knee arthroscopy under local anaesthesia were done at entry and after 1 year. Joint space width was measured in millimeters at the narrowest point of the medial compartment. Chondropathy was scored by using reader's overall assessment (VAS score, 100mm) and Soci  t   Fran  aise d'Arthroscopie ( @entity5 ) score (0-100). RESULTS: @entity0 (665) were randomized and 494 completed the study. After 1 year, intra-group radiological changes and radiological difference between both tenidap groups and the @entity4 group did not reach statistical significance. The intra-group arthroscopic @entity3 was low, but statistically significant in the three study groups. However, there was no statistically significant difference between both tenidap groups and the @entity4 group. CONCLUSIONS: This study failed to demonstrate any difference between the treatment arms with regard to the structural progression of medial @entity2 as measured by radiography and arthroscopy. Arthroscopy did, however, appears to be more sensitive in detecting disease progression than the weight-bearing radiographs with fully extended knees. This study shows that it is possible to complete a large international trial using arthroscopy as an outcome measure of articular cartilage.

title: Arthroscopic evaluation of potential structure-modifying XXXX . A multicenter, randomized, double-blind comparison of tenidap sodium vs @entity4 .

answer: @entity2


abstract: The activity of the alpha interferons against AIDS-related @entity4 ( @entity4 ) has been demonstrated in numerous clinical trials. Unfortunately, most reports have involved small @entity0 cohorts and a variety of dosages and schedules of administration. We report here a series of Phase II trials with interferon alfa-2b (Intron A, Schering Corp., Kenilworth, NJ) involving 114 @entity0 using three dose regimens. @entity0 received 50 X 10(6) IU/m2 intravenously (high dose), 30 X 10(6) IU/m2 subcutaneously (intermediate dose), or 1 X 10(6) IU/m2 subcutaneously (low dose). Clinical responses were seen in all regimens and, overall, 35% of the @entity0 obtained complete or partial remissions. The response rates in the low-, intermediate-, and high-dose groups were 33%, 28%, and 45%, respectively. In addition, high-dose therapy was associated with more rapid time to response. @entity0 with @entity1 and those who lack B symptoms were more likely to respond to therapy; i.e., response rates for @entity0 without B symptoms were 38%, 44%, and 60% in the low-, intermediate-, and high-dose groups, respectively. Seventy (61%) @entity0 had died at the time of data collection, with a median survival of 15 months. Disease stage and the presence of B symptoms significantly affected mortality. Responders enjoyed significantly longer survival (P less than 0.10) than did nonresponders both overall and when adjusted for disease stage. Interferon alfa-2b was generally well tolerated, although almost all @entity0 experienced @entity3 -like symptoms. No life-threatening @entity2 occurred and only six (6%) @entity0 discontinued treatment due to adverse reactions. No significant improvement in immunologic parameters was detected during this study. These studies suggest that, in this disease setting, interferon alfa-2b may be acting through direct antiproliferative effects rather than as an immunomodulator, and higher doses appear to be more effective than very low doses.

title: Treatment of XXXX with interferon alfa-2b (Intron A).

answer: @entity4


abstract: UNASSIGNED: Background   Surgical management of @entity2 is resource intensive and physiologically demanding. In @entity0 with incurable disease, although the indications for surgery are not well defined, palliative benefit can be significant. The goal of this investigation was to compare outcomes of @entity0 who underwent resection and reconstruction of @entity2 with curative intent with those who underwent similar procedures with palliative intent. Methods   A retrospective review of @entity0 who underwent reconstruction for @entity2 between 2008 and 2014 was conducted. @entity0 were divided into curative and palliative groups. Outcomes assessed included @entity3 and survival. Results   A total of 147 @entity0 who underwent 156 operations met inclusion criteria (27 palliative and 129 curative). In both cohorts, the most common histology was @entity4 ( @entity4 ) and the most common primary @entity1 site was the oral cavity. There was no significant difference between the cohorts in the rates of systemic and reconstructive complications, postoperative hospital length of stay, 30-day mortality, and flap survival. Overall survival in palliative @entity0 was significantly shorter compared with curative @entity0 (median OS, 6.2 months vs. 56.1 months, respectively; p   <   0.0001). Among @entity0 undergoing palliative surgery, @entity0 without carotid involvement and those with non- @entity4 were significantly more likely to have longer survival. Conclusion   Surgical resection with reconstruction is possible in head and neck oncologic @entity0 undergoing palliative treatment. Palliative @entity0 have similar short-term outcomes when compared with @entity0 undergoing resection for curative intent. Quality-of-life and economic implications of these approaches deserve closer scrutiny.

title: Palliative Reconstruction for the Management of Incurable XXXX .

answer: @entity2


abstract: The hemocompatibility and biocompatibility of a stent are determined by the physical and electrochemical properties of the stent surface. The aim of this study was to determine the feasibility, safety and efficacy of implantation of a stent coated with @entity3 . Baseline characteristics were collected prospectively. The occurrence of cardiac adverse events and the angina score were assessed at clinical follow-up. A total of 193 Tensum stents were implanted in 174 @entity0 . In hospital, one @entity0 experienced stent @entity1 and in 6% of the @entity0 a @entity2 kinase elevation to 240 U/l or more occurred. Long-term follow-up was performed in 172 @entity0 , with a mean follow-up of 454 +/- 181 days. Ninety-seven per cent were still alive, 15% had undergone target-vessel revascularization, and 2% had angiographic restenosis and were treated with medication only. Seventy-one per cent of the @entity0 were free of anginal complaints, and 20% had anginal complaints in Canadian Cardiac Society class I or II. The Tensum coronary stent showed to be a safe and efficacious device in this study, with a high primary success rate and favorable long-term clinical followup.

title: Initial results and long-term clinical follow-up of an amorphous hydrogenated XXXX -coated stent in daily practice.

answer: @entity3


abstract: BACKGROUND: @entity1 is one of the most serious public health challenges of the 21st century. The prevalence of @entity2 and @entity1 among @entity0 (<5 years) in Cameroon, based on weight-for-height index, has doubled between 1991 and 2006. This study aimed to determine the prevalence and risk factors of @entity2 and @entity1 among @entity0 aged 6 months to 5 years in Cameroon in 2011. METHODS: Four thousand five hundred and eighteen @entity0 (2205 @entity0 and 2313 @entity0 ) aged between 6 to 59 months were sampled in the 2011 Demographic Health Survey (DHS) database. Body Mass Index (BMI) z-scores based on WHO 2006 reference population was chosen to estimate @entity2 (BMI z-score > 2) and @entity1 (BMI for age > 3). Regression analyses were performed to investigate risk factors of @entity2 / @entity1 . RESULTS: The prevalence of @entity2 and @entity1 was 8% (1.7% for @entity1 alone). @entity0 were more affected by @entity2 than @entity0 with a prevalence of 9.7% and 6.4% respectively. The highest prevalence of @entity2 was observed in the Grassfield area (including @entity0 living in West and North-West regions) (15.3%). Factors that were independently associated with @entity2 and @entity1 included: having @entity2 mother (adjusted odds ratio (aOR) = 1.51; 95% CI 1.15 to 1.97) and @entity1 mother (aOR = 2.19; 95% CI = 155 to 3.07), compared to having normal weight mother; high birth weight (aOR = 1.69; 95% CI 1.24 to 2.28) compared to normal birth weight; male gender (aOR = 1.56; 95% CI 1.24 to 1.95); low birth rank (aOR = 1.35; 95% CI 1.06 to 1.72); being aged between 13-24 months (aOR = 1.81; 95% CI = 1.21 to 2.66) and 25-36 months (aOR = 2.79; 95% CI 1.93 to 4.13) compared to being aged 45 to 49 months; living in the grassfield area (aOR = 2.65; 95% CI = 1.87 to 3.79) compared to living in Forest area. Muslim appeared as a protective factor (aOR = 0.67; 95% CI 0.46 to 0.95).compared to Christian religion. CONCLUSION: This study underlines a high prevalence of early childhood @entity2 with significant disparities between ecological areas of Cameroon. Risk factors of @entity2 included high maternal BMI, high birth weight, male gender, low birth rank, aged between 13-36 months, and living in the Grassfield area while being Muslim appeared as a protective factor. Preventive strategies should be strengthened especially in Grassfield areas and should focus on sensitization campaigns to reduce @entity2 and @entity1 in mothers and on reinforcement of measures such as surveillance of weight gain during antenatal consultation and clinical follow-up of @entity0 with high birth weight. Meanwhile, further studies including nutritional characteristics are of great interest to understand the association with religion, @entity0 age and ecological area in this age group, and will help in refining preventive strategies against childhood @entity2 and @entity1 in Cameroon.

title: Prevalence and Risk Factors of Overweight and XXXX among @entity0 Aged 6-59 Months in Cameroon: A Multistage, Stratified Cluster Sampling Nationwide Survey.

answer: @entity1


abstract: BACKGROUND: @entity1 is one of the most serious public health challenges of the 21st century. The prevalence of @entity2 and @entity1 among @entity0 (<5 years) in Cameroon, based on weight-for-height index, has doubled between 1991 and 2006. This study aimed to determine the prevalence and risk factors of @entity2 and @entity1 among @entity0 aged 6 months to 5 years in Cameroon in 2011. METHODS: Four thousand five hundred and eighteen @entity0 (2205 @entity0 and 2313 @entity0 ) aged between 6 to 59 months were sampled in the 2011 Demographic Health Survey (DHS) database. Body Mass Index (BMI) z-scores based on WHO 2006 reference population was chosen to estimate @entity2 (BMI z-score > 2) and @entity1 (BMI for age > 3). Regression analyses were performed to investigate risk factors of @entity2 / @entity1 . RESULTS: The prevalence of @entity2 and @entity1 was 8% (1.7% for @entity1 alone). @entity0 were more affected by @entity2 than @entity0 with a prevalence of 9.7% and 6.4% respectively. The highest prevalence of @entity2 was observed in the Grassfield area (including @entity0 living in West and North-West regions) (15.3%). Factors that were independently associated with @entity2 and @entity1 included: having @entity2 mother (adjusted odds ratio (aOR) = 1.51; 95% CI 1.15 to 1.97) and @entity1 mother (aOR = 2.19; 95% CI = 155 to 3.07), compared to having normal weight mother; high birth weight (aOR = 1.69; 95% CI 1.24 to 2.28) compared to normal birth weight; male gender (aOR = 1.56; 95% CI 1.24 to 1.95); low birth rank (aOR = 1.35; 95% CI 1.06 to 1.72); being aged between 13-24 months (aOR = 1.81; 95% CI = 1.21 to 2.66) and 25-36 months (aOR = 2.79; 95% CI 1.93 to 4.13) compared to being aged 45 to 49 months; living in the grassfield area (aOR = 2.65; 95% CI = 1.87 to 3.79) compared to living in Forest area. Muslim appeared as a protective factor (aOR = 0.67; 95% CI 0.46 to 0.95).compared to Christian religion. CONCLUSION: This study underlines a high prevalence of early childhood @entity2 with significant disparities between ecological areas of Cameroon. Risk factors of @entity2 included high maternal BMI, high birth weight, male gender, low birth rank, aged between 13-36 months, and living in the Grassfield area while being Muslim appeared as a protective factor. Preventive strategies should be strengthened especially in Grassfield areas and should focus on sensitization campaigns to reduce @entity2 and @entity1 in mothers and on reinforcement of measures such as surveillance of weight gain during antenatal consultation and clinical follow-up of @entity0 with high birth weight. Meanwhile, further studies including nutritional characteristics are of great interest to understand the association with religion, @entity0 age and ecological area in this age group, and will help in refining preventive strategies against childhood @entity2 and @entity1 in Cameroon.

title: Prevalence and Risk Factors of Overweight and @entity1 among XXXX Aged 6-59 Months in Cameroon: A Multistage, Stratified Cluster Sampling Nationwide Survey.

answer: @entity0


abstract: @entity3 were induced in BALB/c @entity1 by the intratracheal injection of insoluble polymerized dextran and latex microparticles. Very large @entity4 developed around dextran beads, which reached peak intensity within 2-3 days and rapidly declined in size thereafter. Latex beads generated small stable lesions. The involvement of cell-mediated immunity could not be demonstrated in the inflammatory responses induced by either type of bead. Antigen-induced @entity2 ( @entity2 ) and mitogen-induced @entity2 -like footpad reactions were markedly suppressed in immunized @entity1 bearing early dextran @entity4 . Mitogen-induced @entity2 -like footpad reactions were suppressed in unimmunized animals bearing early dextran @entity5 . Antigen- and mitogen-induced @entity0 recovered to normal levels as dextran @entity4 diminished in size. No suppression of these footpad reactions was observed in @entity1 bearing small latex @entity5 . The intraperitoneal injection of aqueous extracts prepared from the lungs of unimmunized donor animals bearing early dextran @entity5 could partially transfer suppression of mitogen @entity2 -like footpad responses to normal @entity1 . These results suggest that cells within large, nonimmunologic lung @entity4 produce a soluble factor which participates in the expression of anergy-like immunosuppression.

title: Anergy-like immunosuppression in XXXX bearing pulmonary foreign-body granulomatous inflammation.

answer: @entity1


abstract: UNASSIGNED: Purpose To investigate the effect of increasing the overall treatment time as well as delivering the compensating doses on the Balb/c @entity0 . Materials and methods A total of 72 @entity2 were divided into two aliquots (classes A and B) based on the initial size of their induced @entity1 . Each class was divided into a control and several treatment groups. Among the treatment groups, group 1 was continuously exposed to 2 Gy irradiation, and groups 2 and 3 received two subfractions of 1 Gy over the total treatment times of 30 and 60 min, respectively. To investigate the effect of compensating doses, calculated based on the developed linear quadratic model (LQ) model, the remaining two groups (groups 4 and 5) received two subfractions of 1.16 and 1.24 Gy over the total treatment times of 30 and 60 min, respectively. The growing curves, @entity1 Growth Time (TGT), @entity1 Growth Delay Time (TGDT) and the survival of the animals were studied. Results For class A ( @entity1 size    <=   30   mm(3)), the average @entity1 size in the irradiated groups 1-5 was considerably different compared to the control group as one unit (day) change in time, by amount of   -160.8,   -158.9,   +39.4 and   +44.0, respectively. While these amounts were   +22.0,   +17.9,   -21.7 and   -0.1 for class B ( @entity1 size   >=    400   mm(3)). For the class A of animals, the TGT and TGDT parameters were significantly lower (0    <=   0.05) for the groups 2 and 3, compared to group 1. There was no significant difference (p   >   0.05) between groups 1, 4 and 5 in this class. There was no significant difference (p   >   0.05) between all the treated groups in class B. Conclusions Increasing total treatment time affects the radiobiological efficiency of treatment especially in small-sized @entity1 . The compensating doses derived from the LQ model can be used to compensate the effects of prolonged treatment times at in vivo condition.

title: The application of the linear quadratic model to compensate the effects of prolonged fraction delivery time on a Balb/C XXXX : An in vivo study.

answer: @entity0


abstract: Peroxisome proliferator activated receptors (PPARs) are a family of related receptors implicated in a diverse array of biological processes. There are 3 main isotypes of PPARs known as @entity8 , @entity10 and @entity9 and each is organized into domains associated with a function such as ligand binding, activation and DNA binding. PPARs are activated by ligands, which can be both endogenous such as @entity6 or their derivatives, or synthetic, such as peroxisome proliferators, hypolipidaemic drugs, anti-inflammatory or insulin-sensitizing drugs. Once activated, PPARs bind to DNA and regulate gene transcription. The different isotypes differ in their expression patterns, lending clues on their function. @entity8 is expressed mainly in liver whereas @entity9 is expressed in fat and in some macrophages. Activation of @entity8 in rodent liver is associated with peroxisome proliferation and with suppression of apoptosis and induction of cell proliferation. The mechanism by which activation of @entity8 regulates apoptosis and proliferation is unclear but is likely to involve target gene transcription. Similarly, @entity9 is involved in the induction of cell growth arrest occurring during the differentiation process of fibroblasts to adipocytes. However, it has been implicated in the regulation of cell cycle and cell proliferation in @entity4 models. Less in known concerning @entity10 but it was identified as a downstream target gene for @entity5 /beta-catenin/T cell factor-4 @entity1 suppressor pathway, which is involved in the regulation of growth promoting genes such as @entity3 and @entity7 . Marked species and tissue differences in the expression of PPARs complicate the extrapolation of pre-clinical data to @entity0 . For example, @entity8 ligands such as the hypolipidaemic fibrates have been used extensively in the clinic over the past 20 years to treat @entity2 and side effects of clinical fibrate use are rare, despite the observation that these compounds are rodent carcinogens. Similarly, adverse clinical responses have been seen with @entity9 ligands that were not predicted by pre-clinical models. Here, we consider the response to @entity8 ligands seen in pre-clinical models of efficacy and safety in the context of @entity0 health and disease.

title: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for XXXX health and disease.

answer: @entity0


abstract: OBJECTIVE: To observe the dynamic expression of transmembrane (TM)- @entity0 @entity2 factor ( @entity5 and secreted (S)- @entity5 in the development of @entity3 and explore the actions and mechanism of TM- @entity5 in liver of the @entity1 with @entity3 . METHODS: @entity3 in @entity1 was induced by intravenous injection of dead gram negative bacteria @entity4 ; the kinetics of TM- @entity5 on peritoneal macrophages and S- @entity5 in serum of these @entity1 were determined. Pretreatment with @entity5 converting enzyme antisense oligonucleotide (5 mg/kg) 30 minutes before @entity1 were administrated dead bacteria inhibited enzymatic cleavage of TM- @entity5 into S- @entity5 . Six hours after bacteria injection, TM- @entity5 and S- @entity5 were also detected respectively. The pathological injury in the livers of @entity1 with endotoxin shock was examined, and artery pressure was constantly measured. RESULTS: The kinetics of TM- @entity5 expression in the development of @entity3 was different from that of S- @entity5 expression in serum. The expression of TM- @entity5 began to increase on the surface of peritoneal macrophages and liver within 30 min, after bacteria challenge and peaking within a period of 4.5 hours followed by a gradual decrease to a relatively high level which was maintained for at least 24 hours. The @entity6 antisense oligonucleotide pretreated @entity1 showed remarkable increase in TM- @entity5 expression by peritoneal macrophages and liver (P < 0.001), and their arterial blood pressure were maintained within normal levels and there were no detectable pathological changes in their livers. CONCLUSIONS: These findings suggested that TM- @entity5 may be a potent endogenous regulator involved in anti-inflammatory responses to maintain normal arterial pressure and protect liver tissue from pathological injury in during endotoxin shock. This study confirmed the important role of @entity5 in @entity3 which is not only of important theoretical significance, but also of practical interest in providing experimental basis for clinical treatment of endotoxin shock.

title: [The effect of transmembrane- and secreted- @entity0 XXXX factor-alpha on shock liver].

answer: @entity2


abstract: OBJECTIVE: To observe the dynamic expression of transmembrane (TM)- @entity0 @entity2 factor ( @entity5 and secreted (S)- @entity5 in the development of @entity3 and explore the actions and mechanism of TM- @entity5 in liver of the @entity1 with @entity3 . METHODS: @entity3 in @entity1 was induced by intravenous injection of dead gram negative bacteria @entity4 ; the kinetics of TM- @entity5 on peritoneal macrophages and S- @entity5 in serum of these @entity1 were determined. Pretreatment with @entity5 converting enzyme antisense oligonucleotide (5 mg/kg) 30 minutes before @entity1 were administrated dead bacteria inhibited enzymatic cleavage of TM- @entity5 into S- @entity5 . Six hours after bacteria injection, TM- @entity5 and S- @entity5 were also detected respectively. The pathological injury in the livers of @entity1 with endotoxin shock was examined, and artery pressure was constantly measured. RESULTS: The kinetics of TM- @entity5 expression in the development of @entity3 was different from that of S- @entity5 expression in serum. The expression of TM- @entity5 began to increase on the surface of peritoneal macrophages and liver within 30 min, after bacteria challenge and peaking within a period of 4.5 hours followed by a gradual decrease to a relatively high level which was maintained for at least 24 hours. The @entity6 antisense oligonucleotide pretreated @entity1 showed remarkable increase in TM- @entity5 expression by peritoneal macrophages and liver (P < 0.001), and their arterial blood pressure were maintained within normal levels and there were no detectable pathological changes in their livers. CONCLUSIONS: These findings suggested that TM- @entity5 may be a potent endogenous regulator involved in anti-inflammatory responses to maintain normal arterial pressure and protect liver tissue from pathological injury in during endotoxin shock. This study confirmed the important role of @entity5 in @entity3 which is not only of important theoretical significance, but also of practical interest in providing experimental basis for clinical treatment of endotoxin shock.

title: [The effect of transmembrane- and secreted- XXXX @entity2 factor-alpha on shock liver].

answer: @entity0


abstract: @entity4 serotype O157:H7 is a rarely identified organism that has recently been associated with @entity5 in all age groups and with the @entity6 ( @entity6 ) in @entity0 . We now report the development of @entity6 in two young @entity0 following enteric @entity3 with @entity4 O157:H7. Both @entity0 were hospitalized because of the severity of their @entity7 . They later developed major @entity8 requiring transfusion and significant @entity2 requiring, in one case, hemodialysis. One @entity0 underwent laparotomy, where sterile ascites, marked right colonic @entity1 , and intraserosal @entity5 were noted. Both @entity0 survived and are currently improving. Fecal @entity4 serotype O157:H7 was sought only after routine cultures were negative and features of @entity6 were recognized. The search for the @entity4 was facilitated by the continued availability of stool cultures obtained early in the course of the illness. The source of @entity3 was not ascertained, but ingestion of untreated water was a feature of both cases. The @entity6 is a potential complication of the @entity5 associated with @entity4 serotype O157:H7 and may develop in adults as well as @entity0 following enteric @entity3 with this organism.

title: @entity5 with XXXX O157:H7 preceding adult @entity6 .

answer: @entity4


abstract: @entity4 serotype O157:H7 is a rarely identified organism that has recently been associated with @entity5 in all age groups and with the @entity6 ( @entity6 ) in @entity0 . We now report the development of @entity6 in two young @entity0 following enteric @entity3 with @entity4 O157:H7. Both @entity0 were hospitalized because of the severity of their @entity7 . They later developed major @entity8 requiring transfusion and significant @entity2 requiring, in one case, hemodialysis. One @entity0 underwent laparotomy, where sterile ascites, marked right colonic @entity1 , and intraserosal @entity5 were noted. Both @entity0 survived and are currently improving. Fecal @entity4 serotype O157:H7 was sought only after routine cultures were negative and features of @entity6 were recognized. The search for the @entity4 was facilitated by the continued availability of stool cultures obtained early in the course of the illness. The source of @entity3 was not ascertained, but ingestion of untreated water was a feature of both cases. The @entity6 is a potential complication of the @entity5 associated with @entity4 serotype O157:H7 and may develop in adults as well as @entity0 following enteric @entity3 with this organism.

title: XXXX with @entity4 O157:H7 preceding adult @entity6 .

answer: @entity5


abstract: @entity4 serotype O157:H7 is a rarely identified organism that has recently been associated with @entity5 in all age groups and with the @entity6 ( @entity6 ) in @entity0 . We now report the development of @entity6 in two young @entity0 following enteric @entity3 with @entity4 O157:H7. Both @entity0 were hospitalized because of the severity of their @entity7 . They later developed major @entity8 requiring transfusion and significant @entity2 requiring, in one case, hemodialysis. One @entity0 underwent laparotomy, where sterile ascites, marked right colonic @entity1 , and intraserosal @entity5 were noted. Both @entity0 survived and are currently improving. Fecal @entity4 serotype O157:H7 was sought only after routine cultures were negative and features of @entity6 were recognized. The search for the @entity4 was facilitated by the continued availability of stool cultures obtained early in the course of the illness. The source of @entity3 was not ascertained, but ingestion of untreated water was a feature of both cases. The @entity6 is a potential complication of the @entity5 associated with @entity4 serotype O157:H7 and may develop in adults as well as @entity0 following enteric @entity3 with this organism.

title: @entity5 with @entity4 O157:H7 preceding adult XXXX .

answer: @entity6


abstract: Ticks often cluster at preferred feeding sites on hosts, and the co-feeding of ticks at the same site has been shown to increase feeding success and the transmission of some pathogens. While the major route of infection of ticks with pathogens is via the bloodmeal during feeding on a parasitemic host, non-systemic transmission of viruses and spirochetes has been shown to occur from infected to uninfected ticks at common feeding sites on uninfected hosts. In this research, two separate studies were done using the tick-borne rickettsial pathogen of @entity2 , @entity3 . In one study we tested whether A. marginale could be transmitted non-systemically from infected to uninfected Dermacentor variabilis males while co-feeding on @entity0 . Infection of ticks was determined by allowing them to transmission feed on susceptible @entity2 and by DNA probe and microscopy studies on salivary glands. In the second study, we tested whether the co-feeding of male and female ticks on parasitemic @entity2 would increase the acquisition and development of A. marginale in males. A. @entity1 in salivary glands were determined by quantitative PCR after the ticks were allowed to transmission feed on susceptible @entity2 . Non-systemic transmission of A. marginale did not occur from infected and uninfected ticks that fed at the same site on @entity0 and, therefore, does not appear to be a means of A. marginale transmission. A. @entity1 in male ticks were not increased while co-feeding with females. Thus, co-feeding of adult Dermacentor spp. does not appear to influence the dynamics of A. marginale transmission.

title: Co-feeding studies of ticks infected with XXXX .

answer: @entity3


abstract: Ten @entity0 with histologically verified @entity5 were treated between 1974 and 1985. There were eight female and two male @entity0 , ranging in age from 25 to 72 years with a mean age of 45.5 years. @entity2 and disturbed mentation were the most common presenting symptoms whereas corticospinal disturbance, altered mentation and homonymous @entity6 were the most common signs on formal neurological examination. Papilloedema was demonstrable in 50% of cases and evidence of @entity7 was apparent in 60% of @entity0 with lesions affecting their dominant hemisphere. A single instance of drop attack occurred in a @entity0 harbouring a third @entity3 . Computed tomography, with and without contrast enhancement, and angiography were employed in all cases and proved highly sensitive and specific for @entity1 localisation and tissue diagnosis. In addition, angiography proved invaluable in demonstrating both vascular supply and the effects imposed upon the surrounding cerebral vasculature by @entity1 mass and @entity4 . Nine @entity1 occurred in the lateral ventricular trigone of which 5 were left-sided. A tenth @entity1 was located in the third ventricle. Twelve resections were performed in 10 @entity0 . One @entity0 was found to have a highly malignant @entity5 which recurred within 10 weeks of the original surgery and proved fatal shortly thereafter. A second @entity0 whose initial resection was subtotal had a recurrence 3 years postoperatively which was totally resected. Lesions were approached most commonly through the posterior middle or posterior inferior temporal gyri. On 3 occasions a right posterior middle frontal gyrus approach was used and in one case a posterior parieto-occipital cortical incision was employed.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX . A review of 10 cases of the National Hospital, Queen Square (1974-1985) with reference to the literature.

answer: @entity5


abstract: @entity5 is more @entity3 in @entity1 @entity0 than in nondiabetics; they have more diffuse disease, higher mortality rates and worse clinical outcomes after coronary interventions. Intravascular ultrasound (IVUS) produces transmural tomographic images of the coronary arteries in vivo. Recent IVUS studies have provided new insights into the mechanisms of @entity7 formation and @entity4 in both nondiabetic and @entity1 @entity0 . Arterial @entity9 is defined as a change in arterial area. During @entity6 , an increase in arterial area usually accompanies plaque accumulation to delay lumen compromise. @entity7 formation is related to: (a) the rate of plaque accumulation versus the rate of positive @entity9 ; and (b) the limits and ultimate failure of positive @entity9 . However, there is a marked variability in @entity9 . IVUS studies have suggested that @entity9 may be impaired in some @entity1 @entity0 during @entity6 . Following non-stent catheter-based interventions, serial (post-intervention and follow-up) IVUS studies have shown that the change in lumen area correlates better with the change in arterial area ( @entity9 ) than with the change in plaque area (neointimal @entity8 ). In some @entity0 , a positive @entity9 response mitigates against the increase in plaque area to limit late lumen loss and @entity4 . Neointimal @entity8 is exaggerated in @entity1 @entity0 . Despite this, there is a reduced frequency of positive @entity9 , potentially similar to the @entity2 in some @entity1 @entity0 during @entity6 . Failed or inadequate arterial @entity9 may contribute to the pathogenesis and natural history of @entity5 in @entity1 @entity0 .

title: Intravascular ultrasound observations of @entity6 formation and XXXX in @entity0 with @entity1 .

answer: @entity4


abstract: @entity5 is more @entity3 in @entity1 @entity0 than in nondiabetics; they have more diffuse disease, higher mortality rates and worse clinical outcomes after coronary interventions. Intravascular ultrasound (IVUS) produces transmural tomographic images of the coronary arteries in vivo. Recent IVUS studies have provided new insights into the mechanisms of @entity7 formation and @entity4 in both nondiabetic and @entity1 @entity0 . Arterial @entity9 is defined as a change in arterial area. During @entity6 , an increase in arterial area usually accompanies plaque accumulation to delay lumen compromise. @entity7 formation is related to: (a) the rate of plaque accumulation versus the rate of positive @entity9 ; and (b) the limits and ultimate failure of positive @entity9 . However, there is a marked variability in @entity9 . IVUS studies have suggested that @entity9 may be impaired in some @entity1 @entity0 during @entity6 . Following non-stent catheter-based interventions, serial (post-intervention and follow-up) IVUS studies have shown that the change in lumen area correlates better with the change in arterial area ( @entity9 ) than with the change in plaque area (neointimal @entity8 ). In some @entity0 , a positive @entity9 response mitigates against the increase in plaque area to limit late lumen loss and @entity4 . Neointimal @entity8 is exaggerated in @entity1 @entity0 . Despite this, there is a reduced frequency of positive @entity9 , potentially similar to the @entity2 in some @entity1 @entity0 during @entity6 . Failed or inadequate arterial @entity9 may contribute to the pathogenesis and natural history of @entity5 in @entity1 @entity0 .

title: Intravascular ultrasound observations of @entity6 formation and @entity4 in @entity0 with XXXX .

answer: @entity1


abstract: @entity5 is more @entity3 in @entity1 @entity0 than in nondiabetics; they have more diffuse disease, higher mortality rates and worse clinical outcomes after coronary interventions. Intravascular ultrasound (IVUS) produces transmural tomographic images of the coronary arteries in vivo. Recent IVUS studies have provided new insights into the mechanisms of @entity7 formation and @entity4 in both nondiabetic and @entity1 @entity0 . Arterial @entity9 is defined as a change in arterial area. During @entity6 , an increase in arterial area usually accompanies plaque accumulation to delay lumen compromise. @entity7 formation is related to: (a) the rate of plaque accumulation versus the rate of positive @entity9 ; and (b) the limits and ultimate failure of positive @entity9 . However, there is a marked variability in @entity9 . IVUS studies have suggested that @entity9 may be impaired in some @entity1 @entity0 during @entity6 . Following non-stent catheter-based interventions, serial (post-intervention and follow-up) IVUS studies have shown that the change in lumen area correlates better with the change in arterial area ( @entity9 ) than with the change in plaque area (neointimal @entity8 ). In some @entity0 , a positive @entity9 response mitigates against the increase in plaque area to limit late lumen loss and @entity4 . Neointimal @entity8 is exaggerated in @entity1 @entity0 . Despite this, there is a reduced frequency of positive @entity9 , potentially similar to the @entity2 in some @entity1 @entity0 during @entity6 . Failed or inadequate arterial @entity9 may contribute to the pathogenesis and natural history of @entity5 in @entity1 @entity0 .

title: Intravascular ultrasound observations of XXXX formation and @entity4 in @entity0 with @entity1 .

answer: @entity6


abstract: @entity5 is more @entity3 in @entity1 @entity0 than in nondiabetics; they have more diffuse disease, higher mortality rates and worse clinical outcomes after coronary interventions. Intravascular ultrasound (IVUS) produces transmural tomographic images of the coronary arteries in vivo. Recent IVUS studies have provided new insights into the mechanisms of @entity7 formation and @entity4 in both nondiabetic and @entity1 @entity0 . Arterial @entity9 is defined as a change in arterial area. During @entity6 , an increase in arterial area usually accompanies plaque accumulation to delay lumen compromise. @entity7 formation is related to: (a) the rate of plaque accumulation versus the rate of positive @entity9 ; and (b) the limits and ultimate failure of positive @entity9 . However, there is a marked variability in @entity9 . IVUS studies have suggested that @entity9 may be impaired in some @entity1 @entity0 during @entity6 . Following non-stent catheter-based interventions, serial (post-intervention and follow-up) IVUS studies have shown that the change in lumen area correlates better with the change in arterial area ( @entity9 ) than with the change in plaque area (neointimal @entity8 ). In some @entity0 , a positive @entity9 response mitigates against the increase in plaque area to limit late lumen loss and @entity4 . Neointimal @entity8 is exaggerated in @entity1 @entity0 . Despite this, there is a reduced frequency of positive @entity9 , potentially similar to the @entity2 in some @entity1 @entity0 during @entity6 . Failed or inadequate arterial @entity9 may contribute to the pathogenesis and natural history of @entity5 in @entity1 @entity0 .

title: Intravascular ultrasound observations of @entity6 formation and @entity4 in XXXX with @entity1 .

answer: @entity0


abstract: Eighty-five @entity0 (81 males and 4 females) with significant alcoholic histories were studied. @entity4 misuse was directly or indirectly responsible for about 5-10% of hospital admissions in @entity9 Lanka. Prevalence of @entity7 in @entity0 below 40 years (43% of cases) or with a strong family history (56% of cases) were demographic features simulating trends in developed nations. Although rarely an occupational hazard, the majority in this lower socio-economic group drank illicitly-manufactured brews with high @entity4 content while many consumed a mixture of beverages. Lone drinkers were predominant (86%); features of @entity6 were @entity1 (64%), emotional problems (42%) and loneliness (34%); domestic problems (36%), social problems (24%) and financial problems (34%) were also noted. Many such factors, either singly or in combination, initiated or perpetuated the drinking habits of the @entity0 . Drug misuse and suicidal tendencies were not observed. Severe @entity2 was noted in 63% of 42 @entity0 where the histology was demonstrated, and who usually presented with significant @entity5 ; about 50% of @entity0 below the age of 40 had @entity2 of a serious or irreversible nature. Direct @entity3 of @entity8 , toxic contamination during the preparation of illicit brews and nutritional factors appear pertinent to @entity2 in developing nations. Nutritional factors may cause variations in relation to abnormalities in liver function tests and also liver size among the population studied when compared to findings from the western world.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Recent aspects of @entity7 in XXXX Lanka--an increasing health hazard.

answer: @entity9


abstract: Eighty-five @entity0 (81 males and 4 females) with significant alcoholic histories were studied. @entity4 misuse was directly or indirectly responsible for about 5-10% of hospital admissions in @entity9 Lanka. Prevalence of @entity7 in @entity0 below 40 years (43% of cases) or with a strong family history (56% of cases) were demographic features simulating trends in developed nations. Although rarely an occupational hazard, the majority in this lower socio-economic group drank illicitly-manufactured brews with high @entity4 content while many consumed a mixture of beverages. Lone drinkers were predominant (86%); features of @entity6 were @entity1 (64%), emotional problems (42%) and loneliness (34%); domestic problems (36%), social problems (24%) and financial problems (34%) were also noted. Many such factors, either singly or in combination, initiated or perpetuated the drinking habits of the @entity0 . Drug misuse and suicidal tendencies were not observed. Severe @entity2 was noted in 63% of 42 @entity0 where the histology was demonstrated, and who usually presented with significant @entity5 ; about 50% of @entity0 below the age of 40 had @entity2 of a serious or irreversible nature. Direct @entity3 of @entity8 , toxic contamination during the preparation of illicit brews and nutritional factors appear pertinent to @entity2 in developing nations. Nutritional factors may cause variations in relation to abnormalities in liver function tests and also liver size among the population studied when compared to findings from the western world.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Recent aspects of XXXX in @entity9 Lanka--an increasing health hazard.

answer: @entity7


abstract: @entity2 ( @entity2 ) provide the most reliable therapeutic information available. Unfortunately, there are no systemic listing of @entity2 . We compared a MEDLARS search of 3686 biomedical journals for @entity2 with a manual search of the medical literature for the period 1966-1982. For the former search we used subject headings (1) @entity1 or (2) @entity0 and subheadings (1) drug therapy, (2) surgery, (3) radiotherapy, or (4) therapy, and check tags (1) comparative study or (2) clinical research. For the manual search, the contents of 34 arbitrarily selected, gastroenterologic, hepatologic, surgical, or general journals were perused. The MEDLARS search identified 160 @entity2 and 29 others were found in the references of the 160. One hundred fifty-four @entity2 were identified by both methods. The manual search identified 208 @entity2 and an additional 34 were found in the references of the 208. The MEDLARS search identified only 107 of 208 @entity2 found in the references of the 208. The MEDLARS search identified only 107 of 208 @entity2 found manually in the 36 journals, an efficiency rate of 51%. We estimate that 330 hepatobiliary @entity2 had been published during this 17-year period. Sixty percent of the @entity2 found by MEDLARS used the key word "randomized," "double blind," or "controlled" in the title, compared to 36% in those found by the manual search. In order to retrieve @entity2 , it is essential that editors require that @entity2 be identified in their titles or key words by specific terms such as "controlled," "randomized," and "double blind," that papers be so catalogued and indexed, and that searchers be instructed in appropriate search strategies.

title: The retrieval of randomized clinical trials in XXXX from the medical literature. A comparison of MEDLARS and manual methods.

answer: @entity1


abstract: UNASSIGNED: This study aims to ascertain the relationship of @entity1 metastasis-associated markers @entity4 , @entity5 ( @entity5 ) and @entity2 ( @entity2 ) with the clinicopathologic features and prognosis of @entity0 with @entity3 ( @entity3 ), and to investigate their value in @entity3 molecular classification. The expression of @entity4 , @entity5 and @entity2 in 100 specimens from @entity0 and 20 from normal esophageal mucosa were detected by immunohistochemistry. The relationship of their expression with prognosis of the @entity0 with @entity3 was evaluated by Cox regression model and Kaplan-Meier survival curve analysis. High levels of expression of @entity4 , @entity5 , and @entity2 were observed in 61 (61%), 53 (53%), 49 (49%) cases, respectively. Univariate survival analysis indicated that the levels of expression of @entity4 , @entity5 and @entity2 were associated with survival (all P-value < 0.05). Multivariate analysis indicated that @entity4 and @entity2 were independent prognostic factors affecting the three-year survival rate of @entity0 (P = 0.001, 0.017, respectively). Furthermore, high level expression of @entity4 , @entity5 and @entity2 in stage I @entity0 was found associated with poor three-year survival rate (all P-value < 0.05). The prognosis probably was favorable for @entity0 with low expression of @entity4 even in stage III, or @entity2 even in stage IV. Tumor metastasis-associated markers such as @entity4 and @entity2 may be independent prognostic factors affecting survival rate of postoperative @entity3 @entity0 . It is possible to judge prognosis better and tailor treatments to each individual @entity0 when these markers were applied to @entity3 molecular classification.

title: Evaluation of @entity1 metastasis-associated markers for molecular classification in @entity0 with XXXX .

answer: @entity3


abstract: UNASSIGNED: This study aims to ascertain the relationship of @entity1 metastasis-associated markers @entity4 , @entity5 ( @entity5 ) and @entity2 ( @entity2 ) with the clinicopathologic features and prognosis of @entity0 with @entity3 ( @entity3 ), and to investigate their value in @entity3 molecular classification. The expression of @entity4 , @entity5 and @entity2 in 100 specimens from @entity0 and 20 from normal esophageal mucosa were detected by immunohistochemistry. The relationship of their expression with prognosis of the @entity0 with @entity3 was evaluated by Cox regression model and Kaplan-Meier survival curve analysis. High levels of expression of @entity4 , @entity5 , and @entity2 were observed in 61 (61%), 53 (53%), 49 (49%) cases, respectively. Univariate survival analysis indicated that the levels of expression of @entity4 , @entity5 and @entity2 were associated with survival (all P-value < 0.05). Multivariate analysis indicated that @entity4 and @entity2 were independent prognostic factors affecting the three-year survival rate of @entity0 (P = 0.001, 0.017, respectively). Furthermore, high level expression of @entity4 , @entity5 and @entity2 in stage I @entity0 was found associated with poor three-year survival rate (all P-value < 0.05). The prognosis probably was favorable for @entity0 with low expression of @entity4 even in stage III, or @entity2 even in stage IV. Tumor metastasis-associated markers such as @entity4 and @entity2 may be independent prognostic factors affecting survival rate of postoperative @entity3 @entity0 . It is possible to judge prognosis better and tailor treatments to each individual @entity0 when these markers were applied to @entity3 molecular classification.

title: Evaluation of XXXX metastasis-associated markers for molecular classification in @entity0 with @entity3 .

answer: @entity1


abstract: UNASSIGNED: This study aims to ascertain the relationship of @entity1 metastasis-associated markers @entity4 , @entity5 ( @entity5 ) and @entity2 ( @entity2 ) with the clinicopathologic features and prognosis of @entity0 with @entity3 ( @entity3 ), and to investigate their value in @entity3 molecular classification. The expression of @entity4 , @entity5 and @entity2 in 100 specimens from @entity0 and 20 from normal esophageal mucosa were detected by immunohistochemistry. The relationship of their expression with prognosis of the @entity0 with @entity3 was evaluated by Cox regression model and Kaplan-Meier survival curve analysis. High levels of expression of @entity4 , @entity5 , and @entity2 were observed in 61 (61%), 53 (53%), 49 (49%) cases, respectively. Univariate survival analysis indicated that the levels of expression of @entity4 , @entity5 and @entity2 were associated with survival (all P-value < 0.05). Multivariate analysis indicated that @entity4 and @entity2 were independent prognostic factors affecting the three-year survival rate of @entity0 (P = 0.001, 0.017, respectively). Furthermore, high level expression of @entity4 , @entity5 and @entity2 in stage I @entity0 was found associated with poor three-year survival rate (all P-value < 0.05). The prognosis probably was favorable for @entity0 with low expression of @entity4 even in stage III, or @entity2 even in stage IV. Tumor metastasis-associated markers such as @entity4 and @entity2 may be independent prognostic factors affecting survival rate of postoperative @entity3 @entity0 . It is possible to judge prognosis better and tailor treatments to each individual @entity0 when these markers were applied to @entity3 molecular classification.

title: Evaluation of @entity1 metastasis-associated markers for molecular classification in XXXX with @entity3 .

answer: @entity0


abstract: OBJECTIVES: To determine whether the attitudes to sexual and reproductive health of a cohort of university students had changed from 2005 to 2013. METHODS: Questionnaires (1,000) on sexual and reproductive health attitudes were randomly distributed to students at Shanghai Jiaotong University in May 2013. All @entity0 volunteered for the study and their answers were anonymous. The questionnaire contents included personal information and 72 MCQs, which covered four categories: knowledge about @entity2 and @entity4 ; attitude to @entity1 ; attitudes to pornographic books/movies; desire of the @entity0 for education on @entity2 . The @entity0 had not received @entity2 education since their admission to the university. Their study majors were broadly similar to those @entity0 in the April 2005 survey. The high sensitivity of the content of the questionnaire made it imperative to maintain anonymity and high security of the collected data. RESULTS: The return rate of questionnaires were 98% (request age from 19~21 years). Personal hygiene was much greater in females than in males. The proportion of females and males who held a positive attitude to premarital @entity1 was significantly increased (P < 0.0001). 80% of the @entity0 understood the need to use condoms with strangers; however, still high proportion of @entity0 lacked of this knowledge (P = 0.142). About one third of the @entity0 still did not believe that unmarried pregnancy was acceptable (no significant change from 2005 to 2013). There was significantly improved knowledge about the way in which @entity3 spreads. CONCLUSIONS: College students are more open today compared to the 2003 survey. A higher level of sexual knowledge has been achieved but there scope for further improvement. Sex education should be based on the actual needs of young @entity0 , teaching reforms, and special attention paid to practical teaching.

title: View changes and educational demands on XXXX of students at Shanghai Jiaotong University.

answer: @entity2


abstract: BACKGROUND: Energy drink consumption among youth is increasing despite recommendations by the American Academy of Pediatrics to eliminate consumption by youth. This study provides information on consumption of energy drinks and @entity1 mixed with energy drinks (AmED) in a sample of Israeli youth and how consumer knowledge about the risks affects consumption rates. METHODS: The study was conducted in three Tel Aviv public schools, with a total enrollment of 1,253 students in grades 8 through 12. Among them, 802 students completed a 49-item questionnaire about energy drink and AmED consumption, for a 64  % response rate Non-responders included 451 students who were absent or refused to participate. All students in the same school were administered the questionnaire on the same day. RESULTS: Energy drinks are popular among youth (84.2  % have ever drunk). More tenth through twelfth grade students consumed energy drinks than eighth and ninth grade students. Students who began drinking in elementary school (36.8  %) are at elevated risk for current energy drink (P   <   .001) and AmED (P   =   .002) use. Knowledge about amounts consumed and recommended allowances is associated with less consumption (OR 1.925; 95  %CI 1.18-3.14). DISCUSSION: The association between current AmED consumption and drinking @entity2 at a young age is important. @entity0 and those who start drinking early have a greater risk of both @entity2 and AmED consumption. The characteristics of early drinkers can help increase awareness of potential at-risk youth, such as junior and senior high school students with less educated or single parents. CONCLUSIONS: Risks posed by early use on later energy drink and AmED consumption are concerning. We suggest that parents should limit accessibility. Increased knowledge about acceptable and actual amounts of @entity3 in a single product might decrease consumption.

title: A survey of energy drink and XXXX mixed with energy drink consumption.

answer: @entity1


abstract: We aimed to estimate clinicians' based risk thresholds at which febrile @entity0 would be managed as @entity4 ( @entity4 ) to determine influencing characteristics and to compare thresholds with prediction model (Feverkidstool) risk estimates. Twenty-one video vignettes of febrile @entity0 visiting the @entity2 ( @entity2 ) were assessed by 42 (40.4  %) international paediatricians/paediatric emergency clinicians. Questions were related to clinical risk scores of the @entity0 having @entity4 and @entity4 management decisions on visual analogue scales. Feverkidstool risk scores were based on clinical signs/symptoms and @entity3 . Amongst vignettes assigned to @entity4 management, the median risk was 60  % (interquartile range (IQR) 30.0-80.5) and 16.0  % (IQR 5.0-32.0) when vignettes were not managed as @entity4 . Ill appearance and aberrant circulatory signs were the most influencing factors, as age and duration of @entity1 were the least influencing factors on @entity4 management decisions. Feverkidstool risk scores varied from 13  % (IQR 7.7-28.1) for @entity4 management to 7.3  % (IQR 5.7-16.3) for no @entity4 management. CONCLUSION: Clinicians assigned high risk scores to @entity0 who they would have managed as @entity4 , mostly influenced by ill appearance and aberrant circulation. In contrast to @entity4 risk assessment of the Feverkidstool, clinicians' appeared to apply a more stepwise assessment of the risk of presence/absence of @entity4 at different steps in the diagnostic and therapeutic process. Uniform risk thresholds at which one should start @entity4 management in febrile @entity0 remains unclear; risk thresholds at which we refrained from @entity4 management were more consistent. WHAT IS KNOWN:    Only a small proportion of febrile @entity0 presenting to the @entity2 will have @entity4 ( @entity4 ) and uniform risk thresholds to start or withhold @entity4 treatment are not known.    The low prevalence of @entity4 and consequently the low exposure of clinicians to these infections make them rely more on alarming signs or clinical decision rules. What is New:    Previously identified model predictors for @entity4 appeared to be significantly influencing factors in clinicians' febrile @entity0 management in emergency care.    Clinicians' wielded higher risk thresholds regarding @entity4 febrile @entity0 management than reflected by the clinical prediction model while smaller differences in risk thresholds between clinical and model prediction  were observed  when clinicians refrained   from @entity4 management.

title: Clinicians' overestimation of febrile XXXX risk assessment.

answer: @entity0


abstract: A vascularized segmental autotransplantation of distal 80% of the pancreas to the right iliopelvic space was successfully performed in a 51-year-old male who had @entity6 . Distal 80% of the gland with severe calcified pancreatitic change was resected and prepared for transplantation by injecting the splenic artery with Ringer's @entity4 solution containing heparin, albumin and gabexate mecilate cooled to 4 degrees C. The spleen was removed from the specimen. An @entity5 was constructed at the tail. End-to-side @entity1 of spleno-external iliac veins was carried out after small fusiform resection of the iliac venous wall for the purpose of sufficient venous patency. End-to-end @entity1 of @entity2 was done. The pancreatic stump was anastomosed to the ileum. Post-operatively, the @entity0 completely resolved. Patency of the graft was demonstrated by angiography. Higher response of the C-peptide immunoreactivity on 75 g OGTT was found in the iliac vein on the transplanted side than in another peripheral vein. The exocrine pancreatic function diagnostant test showed 78.8% post-operatively (vs. 63.2% pre-operatively). Vascularized segmental pancreatic autotransplantation offers an excellent method of relieving @entity0 with preservation of endocrine and exocrine functions in selected cases with chronic @entity3 .

title: [A clinical report of vascularized segmental pancreatic autotransplantation in chronic XXXX ].

answer: @entity3


abstract: The fundamental and clinical studies of @entity3 suppository (CZX-S) in the field of pediatrics were made, with the following results. The serum concentration of CZX in the CZX-S 250 mg-administered group peaked 6.00-22.5 micrograms/ml during the period of 15 minutes to 1-hour after dosing, and gradually declined thereafter. The half-life was 1.37-3.81 hours. In the CZX-S 125 mg-administered group, the serum concentration peaked 2.25-21.0 micrograms/ml at 15-30 minutes after dosing and decreased with time. The half-life was 0.95--1.84 hours. The 6-hour urinary recovery rate of CZX in the CZX-S 250 mg group was 22.0-47.5%. The 6-hour urinary recovery rate in the CZX-S 125 mg group was 17.2-25.3%. CZX-S was given 12-73 mg/kg/day (divided into 1-3 times) to 7 @entity0 with @entity2 etc. who were considered to respond well to the drug. The clinical effectiveness rate was 100% inclusive of "excellent" and "good". The side effect of @entity1 on insertion was encountered in 1 @entity0 .

title: [Fundamental and clinical studies of XXXX suppositories in the pediatric field].

answer: @entity3


abstract: UNASSIGNED:     Background: To investigate @entity0 survival and technical failure of @entity0 with prior @entity1 receiving continuous ambulatory peritoneal dialysis (CAPD) in Southern China.     Methods: This was a retrospective study. All subjects were recruited from the peritoneal dialysis center in The First Affiliated Hospital of Sun Yat-sen University from 1 January 2006 to 31 December 2010. All eligible @entity0 were assigned to @entity1 group and non- @entity1 group according to a history of @entity1 before receiving CAPD. The primary outcomes were all-cause mortality and death-censored technical failure. Cox regression was used to estimate risk factors of all-cause mortality and death-censored technique failure.     Results: Of the 1,068 recruited @entity0 , 75 (7.0%) @entity0 had a previous history of @entity1 . The all-cause mortality and death-censored technique failure were significantly higher in the @entity1 group compared with the non- @entity1 group, respectively (odds ratio [OR] 2.67, 95% confidence interval [CI] 1.59 - 4.46 and OR 2.52, 95% CI 1.19 - 5.34). Older age (changed by 10 years, hazard ratio [HR] 1.90, 95% CI 1.07 - 3.38), lower body mass index (BMI 18.5 - 23.9 vs < 18.5 kg/m2 reference, HR 0.17, 95% CI 0.05 - 0.55) and time to the first episode of @entity2 (HR 0.93, 95% CI 0.89- 0.96) were independently associated with increased risk of all-cause mortality in @entity0 with prior @entity1 . In addition, time to the first episode of @entity2 was associated with decreased risk of death-censored technique failure (HR 0.91, 95% CI 0.84 - 0.99) in those with prior @entity1 .     Conclusions: Continuous ambulatory peritoneal dialysis @entity0 with prior @entity1 had high rates of all-cause mortality and technique failure compared with those without prior @entity1 . Older age, lower BMI, and time to the first episode of @entity2 were independent risk factors of all-cause mortality in @entity0 with prior @entity1 .

title: XXXX SURVIVAL AND TECHNIQUE FAILURE IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS @entity0 WITH PRIOR STROKE.

answer: @entity0


abstract: UNASSIGNED:     Background: To investigate @entity0 survival and technical failure of @entity0 with prior @entity1 receiving continuous ambulatory peritoneal dialysis (CAPD) in Southern China.     Methods: This was a retrospective study. All subjects were recruited from the peritoneal dialysis center in The First Affiliated Hospital of Sun Yat-sen University from 1 January 2006 to 31 December 2010. All eligible @entity0 were assigned to @entity1 group and non- @entity1 group according to a history of @entity1 before receiving CAPD. The primary outcomes were all-cause mortality and death-censored technical failure. Cox regression was used to estimate risk factors of all-cause mortality and death-censored technique failure.     Results: Of the 1,068 recruited @entity0 , 75 (7.0%) @entity0 had a previous history of @entity1 . The all-cause mortality and death-censored technique failure were significantly higher in the @entity1 group compared with the non- @entity1 group, respectively (odds ratio [OR] 2.67, 95% confidence interval [CI] 1.59 - 4.46 and OR 2.52, 95% CI 1.19 - 5.34). Older age (changed by 10 years, hazard ratio [HR] 1.90, 95% CI 1.07 - 3.38), lower body mass index (BMI 18.5 - 23.9 vs < 18.5 kg/m2 reference, HR 0.17, 95% CI 0.05 - 0.55) and time to the first episode of @entity2 (HR 0.93, 95% CI 0.89- 0.96) were independently associated with increased risk of all-cause mortality in @entity0 with prior @entity1 . In addition, time to the first episode of @entity2 was associated with decreased risk of death-censored technique failure (HR 0.91, 95% CI 0.84 - 0.99) in those with prior @entity1 .     Conclusions: Continuous ambulatory peritoneal dialysis @entity0 with prior @entity1 had high rates of all-cause mortality and technique failure compared with those without prior @entity1 . Older age, lower BMI, and time to the first episode of @entity2 were independent risk factors of all-cause mortality in @entity0 with prior @entity1 .

title: @entity0 SURVIVAL AND TECHNIQUE FAILURE IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS XXXX WITH PRIOR STROKE.

answer: @entity0


abstract: AIMS: Soft and small coils are known to be appropriate for the treatment of small @entity2 . The purpose of this study was to determine whether the new HyperSoft   helical coil, which is softer and smaller than its predecessors, has any effect on the packing performance in a matched-pair study with an old HyperSoft   helical coil. MATERIALS AND METHODS: Thirty-six consecutive @entity0 harboring 43 @entity1 treated with new HyperSofts were included in this study. Forty-one @entity2 treated with old HyperSofts were identified from our database as matched controls based on similar volumes and locations. Packing attenuation, adverse events during the procedures, and angiographic occlusions were observed and compared between the two groups. RESULTS: The mean packing density was significantly higher in the new HyperSoft   group compared to the control group (35.5% vs. 26.9%), and a larger proportion of the @entity2 embolized with the 1.5   mm size coil, which has higher packing density. There was no difference in immediate and midterm angiographic outcomes. There was no difference in the rate of intraprocedural perforation, but there was no intraprocedural rupture related to the 1.5   mm coil. CONCLUSIONS: The use of new HyperSoft   helical coils allows higher packing density comparable with the old technology. New HyperSoft   coils, especially those with 1.5   mm loop diameter, can be expected to fill smaller residual spaces in small @entity2 and may be helpful in preventing recanalization.

title: Endovascular coiling of small XXXX using a very soft bare platinum coil: A comparison of the packing performance of new and old HyperSoft   helical coils.

answer: @entity1


abstract: BACKGROUND: Warthin @entity1 presenting concomitantly with a @entity2 is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a @entity3 involving the @entity2 of a @entity4 . CASE PRESENTATION: A seventy-seven year old otherwise healthy gentleman with a 50-pack year smoking history presents with a slowly enlarging left cheek mass. CT scan of the neck demonstrated a left @entity1 measuring 3.4 cm in greatest dimension. He underwent a left superficial parotidectomy, with subsequent histopathologic examination revealing a @entity4 with extensive expansion of the @entity2 . Flow cytometric, immunohistochemical, and cytogenetic studies of the stromal component of the @entity1 confirmed the presence of a @entity3 . Clinical staging demonstrated stage IVa disease, and was considered to be at low to intermediate risk due to the slow growth of the parotid lesion. The @entity0 is undergoing close follow up with repeat PET-CT scans at six months. CONCLUSION: To the best of our knowledge, this is the first well documented collision @entity1 between @entity3 and a @entity4 . This case also brings to light the significance of thorough evaluation of the lymphoid component of @entity4 .

title: An unusual initial presentation of @entity3 arising from the XXXX of @entity4 .

answer: @entity2


abstract: BACKGROUND: Warthin @entity1 presenting concomitantly with a @entity2 is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a @entity3 involving the @entity2 of a @entity4 . CASE PRESENTATION: A seventy-seven year old otherwise healthy gentleman with a 50-pack year smoking history presents with a slowly enlarging left cheek mass. CT scan of the neck demonstrated a left @entity1 measuring 3.4 cm in greatest dimension. He underwent a left superficial parotidectomy, with subsequent histopathologic examination revealing a @entity4 with extensive expansion of the @entity2 . Flow cytometric, immunohistochemical, and cytogenetic studies of the stromal component of the @entity1 confirmed the presence of a @entity3 . Clinical staging demonstrated stage IVa disease, and was considered to be at low to intermediate risk due to the slow growth of the parotid lesion. The @entity0 is undergoing close follow up with repeat PET-CT scans at six months. CONCLUSION: To the best of our knowledge, this is the first well documented collision @entity1 between @entity3 and a @entity4 . This case also brings to light the significance of thorough evaluation of the lymphoid component of @entity4 .

title: An unusual initial presentation of XXXX arising from the @entity2 of @entity4 .

answer: @entity3


abstract: BACKGROUND: Warthin @entity1 presenting concomitantly with a @entity2 is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a @entity3 involving the @entity2 of a @entity4 . CASE PRESENTATION: A seventy-seven year old otherwise healthy gentleman with a 50-pack year smoking history presents with a slowly enlarging left cheek mass. CT scan of the neck demonstrated a left @entity1 measuring 3.4 cm in greatest dimension. He underwent a left superficial parotidectomy, with subsequent histopathologic examination revealing a @entity4 with extensive expansion of the @entity2 . Flow cytometric, immunohistochemical, and cytogenetic studies of the stromal component of the @entity1 confirmed the presence of a @entity3 . Clinical staging demonstrated stage IVa disease, and was considered to be at low to intermediate risk due to the slow growth of the parotid lesion. The @entity0 is undergoing close follow up with repeat PET-CT scans at six months. CONCLUSION: To the best of our knowledge, this is the first well documented collision @entity1 between @entity3 and a @entity4 . This case also brings to light the significance of thorough evaluation of the lymphoid component of @entity4 .

title: An unusual initial presentation of @entity3 arising from the @entity2 of XXXX .

answer: @entity4


abstract: UNASSIGNED: Aim To determine clinical prognostic factors and their impact on the risk of recurrence of newly discovered non-muscle-invasive @entity2 . Methods The study included 120 @entity0 of both sexes aged 45-80 years with newly discovered non-muscle-invasive @entity2 . All the @entity0 were treated surgically by transurethral electro resection (TUER). The outcome of @entity0 with and without recurrence was followed at intervals of three months after surgery, the total of two years. For monitoring the probability of early recurrence the criteria of the European Organization for Research and Treatment of @entity1 (EORTC) were used. Results The average age of the @entity0 was 65.9 years, 79 (79.2%) males and 21 (20.8%) females. The total of 67 (55.8%) @entity0 had a recurrence during the period of monitoring. The average time to the first and fourth recurrence was 15.4 and 23.9 months, respectively. Numbers of @entity1 and a degree of invasion had a significant prognostic impact on the risk of recurrence. The EORTC score was a highly significant predictor of recurrence (OR=1.237; p < 0.001). Conclusion Based on available clinical and pathological prognostic factors and by stratification of @entity0 into three disease risk groups it is possible to predict the possibility of disease. Individual approach and recommendations for the treatment using EORTC risk tables should improve the quality of treatment.

title: Predicting recurrence of non-muscle-invasive XXXX after transurethral resection.

answer: @entity2


abstract: BACKGROUND: We aimed to assess the oxidant/antioxidant status within the ex vivo @entity0 coronary endarterectomy samples. METHODS: To achieve this, we measured products of lipid oxidation ( @entity4 , @entity9 ), lipids ( @entity1 , @entity5 ) and @entity2 in endarterectomy samples. RESULTS: Content of @entity4 in the plaque ranged from 0.23 to 37.36 microg/g. Unesterified @entity1 content ranged from 0.30 to 1.94 mg/g. It was 9.04+/-4.32% of total @entity1 . Total @entity1 content ranged from 1.73 to 23.69 mg/g. @entity10 content ranged from 0.57 to 19.10 mg/g, which is 11.43-60.86% of the total @entity6 (mean+/-SD 40.27+/-18.42%). @entity7 content ranged from 0.24 to 5.76 mg/g, being 9.97-21.81% of total @entity6 (mean+/-SD 14.35+/-4.51%). @entity8 content ranged from 1.05 to 8.21 mg/g, being 17.84-45.15% of total @entity6 (mean+/-SD 30.78+/-11.69%). @entity11 content ranged from 0.51 to 4.20 mg/g, which is 7.56-22.87% of total @entity6 (mean+/-SD 14.60+/-5.60%). The @entity8 / @entity7 ratio (CL/CO) ranged from 1.01 to 4.33. Content of @entity9 in the plaque ranged from 0.0 to 577.5 ng/g of wet weight. The @entity9 /total @entity1 ratio was 0.003+/-0.003% (range from 0.0% to 0.008%). The @entity9 /unesterified @entity1 ratio was 0.024+/-0.023% (range from 0.0% to 0.066%). The plaque content of @entity2 ranged from 0.0 to 40.9 microg/g of wet weight. CONCLUSION: The present study, comprising measurements of lipids, products of lipid peroxidation and @entity2 in 12 @entity0 coronary endarterectomy samples, lends the evidence for ongoing lipid peroxidation within an @entity3 .

title: Lipid peroxidation and XXXX in @entity0 coronary atherosclerotic lesions.

answer: @entity2


abstract: BACKGROUND: We aimed to assess the oxidant/antioxidant status within the ex vivo @entity0 coronary endarterectomy samples. METHODS: To achieve this, we measured products of lipid oxidation ( @entity4 , @entity9 ), lipids ( @entity1 , @entity5 ) and @entity2 in endarterectomy samples. RESULTS: Content of @entity4 in the plaque ranged from 0.23 to 37.36 microg/g. Unesterified @entity1 content ranged from 0.30 to 1.94 mg/g. It was 9.04+/-4.32% of total @entity1 . Total @entity1 content ranged from 1.73 to 23.69 mg/g. @entity10 content ranged from 0.57 to 19.10 mg/g, which is 11.43-60.86% of the total @entity6 (mean+/-SD 40.27+/-18.42%). @entity7 content ranged from 0.24 to 5.76 mg/g, being 9.97-21.81% of total @entity6 (mean+/-SD 14.35+/-4.51%). @entity8 content ranged from 1.05 to 8.21 mg/g, being 17.84-45.15% of total @entity6 (mean+/-SD 30.78+/-11.69%). @entity11 content ranged from 0.51 to 4.20 mg/g, which is 7.56-22.87% of total @entity6 (mean+/-SD 14.60+/-5.60%). The @entity8 / @entity7 ratio (CL/CO) ranged from 1.01 to 4.33. Content of @entity9 in the plaque ranged from 0.0 to 577.5 ng/g of wet weight. The @entity9 /total @entity1 ratio was 0.003+/-0.003% (range from 0.0% to 0.008%). The @entity9 /unesterified @entity1 ratio was 0.024+/-0.023% (range from 0.0% to 0.066%). The plaque content of @entity2 ranged from 0.0 to 40.9 microg/g of wet weight. CONCLUSION: The present study, comprising measurements of lipids, products of lipid peroxidation and @entity2 in 12 @entity0 coronary endarterectomy samples, lends the evidence for ongoing lipid peroxidation within an @entity3 .

title: Lipid peroxidation and @entity2 in XXXX coronary atherosclerotic lesions.

answer: @entity0


abstract: UNASSIGNED: The aim of this study was to investigate the topological reorganization of the @entity1 ( @entity5 ) in @entity0 with @entity4 ( @entity4 ) using resting-state functional magnetic resonance imaging (rs-fMRI). With approval by our ethics committee, rs-fMRI was prospectively performed in 31 @entity4 @entity0 (25 male, 27        8  years) and 32 healthy controls (25 male, 29        9  years). The @entity5 was determined by unbiased seed-based functional connectivity (FC) analysis and then parcellated into several subregions. FC across all pairs of @entity5 subregions was computed to construct the @entity5 architecture, for which topological properties were characterized by graph theoretical approaches. Pearson correlation was performed between abnormal @entity5 inter-regional FC and network measures and clinical indices in @entity4 @entity0 . Compared to healthy controls, @entity4 @entity0 showed decreased @entity5 inter-regional FC between the anterior cingulate cortex and precuneus, the medial orbital of the superior frontal gyrus (ORBsupmed) and precuneus, and the middle temporal gyrus and precuneus. @entity4 @entity0 also showed @entity5 (E glob). Inclusion of @entity2 and @entity3 as covariates abolished FC between ORBsupmed and precuneus and some E glob differences. The average @entity5 FC was positively correlated with average E glob (r   =   0.47, P   =   0.008) and negatively correlated with symptom severity score (r   =   -0.37, P   =   0.04) in @entity4 @entity0 . In conclusion, @entity4 @entity0 showed topological reorganization of the @entity5 to a non-optimized regularity configuration, which may partly be ascribed to high levels of @entity2 and @entity3 .

title: Topological Reorganization of the Default Mode Network in XXXX .

answer: @entity4


abstract: BACKGROUND: In a context where there is an increasing demand to evaluate the outcome of bio-medical research, our work aims to develop a set of indicators to measure the impact of translational @entity1 research. The objective of our study was to explore the scope and issues of translational research relevant to evaluation, explore the views of researchers on the evaluation of oncological translational research, and select indicators measuring the outcomes and outputs of translational research in oncology by consensus. METHODS: Semi-structured interviews amongst 23 researchers involved in translational @entity1 research were conducted and analysed using thematic analysis. A two-round modified Delphi survey of 35 @entity0 with similar characteristics was then performed followed by a physical meeting. @entity0 rated the feasibility and validity of 60 indicators. The physical meeting was held to discuss the methodology of the new indicators. RESULTS: The main themes emerging from the interviews included a common definition for translational research but disagreements about the exact scope and limits of this research, the importance of multidisciplinarity and collaboration for the success of translational research, the disadvantages that translational research faces in current evaluation systems, the relative lack of pertinence of existing indicators, and propositions to measure translational @entity1 research in terms of clinical applications and @entity0 outcomes. A total of 35 @entity0 took part in the first round survey and 12 in the second round. The two-round survey helped us select a set of 18 indicators, including four that seemed to be particularly adapted to measure translational @entity1 research impact on health service research (number of biomarkers identified, generation of clinical guidelines, citation of research in clinical guidelines, and citation of research in public health guidelines). The feedback from @entity0 helped refine the methodology and definition of indicators not commonly used. CONCLUSION: Indicators need to be accepted by stakeholders under evaluation. This study helped the selection and refinement of indicators considered as the most relevant by researchers in translational @entity1 research. The feasibility and validity of those indicators will be tested in a scientometric study.

title: Identifying potential indicators to measure the outcome of translational XXXX research: a mixed methods approach.

answer: @entity1


abstract: Fibromuscular disease of the carotid artery was identified in 30 @entity0 , which represented 3.2 percent of all @entity0 who had cerebral angiography at Brooke Army Medical Center in the 6 year period from 1978 to 1984. Focal neurologic events were the presenting symptoms in 63 percent of the @entity0 . The majority of the @entity0 were treated with antiplatelet therapy, and eight @entity0 had a total of 10 carotid artery dilatations. The only @entity0 with recurrent symptoms were those who received either no treatment or antiplatelet therapy. There were no recurrent symptoms in the operated @entity0 . This study suggests that surgical treatment for the symptomatic @entity0 may prevent recurrent symptoms with an acceptably low morbidity and mortality. There was, however, no indication that prophylactic dilation of the fibromuscular disease in the asymptomatic @entity0 was beneficial. @entity6 of the carotid arteries is often associated with @entity3 , and surgical therapy rather than antiplatelet therapy may be advisable in @entity0 who have @entity3 . @entity0 with concomitant @entity4 of the carotid artery bifurcation should be treated like any @entity0 with @entity4 and an endarterectomy should be performed with carotid dilatation when indicated. Fibromuscular disease of the carotid artery is an infrequent angiographic finding that is associated with focal and @entity1 . Most @entity0 can be effectively treated with antiplatelet drugs with no recurrent symptoms, however, for persistent or progressive symptoms, some @entity0 will require surgical dilatation of the carotid artery. Fibromuscular disease of the carotid artery may lead to catastrophic symptoms of @entity2 or @entity5 if left undiagnosed or untreated.

title: XXXX of the carotid arteries.

answer: @entity6


abstract: BACKGROUND AND PURPOSE: We retrospectively analyzed our results with Guglielmi detachable coils (GDCs) for the endovascular occlusion of acutely @entity8 over 10 years. METHODS: Between 1991-2000, 83 @entity0 (mean age, 56.1 years) with @entity7 were treated with endovascular GDCs. @entity0 with @entity6 due to @entity2 or dissection and those with mycotic or fusiform @entity6 were excluded. Mean follow-up in survivors was 19.1 months, and the mean Hunt-Hess grade at admission was 2.2. Angiographic follow-up was performed in 93% of surviving @entity0 (mean interval, 11.6 months). The basilar caput (34 @entity0 ) and anterior communicating artery complex (19 @entity0 ) were most commonly treated. RESULTS: Sixty-four @entity0 (77%) had a Glasgow Outcome Scale score (GOS) of 4 or 5, nine (11%) had a score of 2 or 3, and 10 (12%) died. At follow-up, 24 @entity0 (35%) had complete @entity6 , 18 (26%) had a @entity4 -ear remnant, 24 (35%) had a residual neck, and two (3%) had residual @entity6 . No treated @entity6 rebled. Three @entity0 required surgical repair after incomplete endovascular treatment. Two or more @entity5 procedures were required in 28 @entity0 (34%). Major procedural complications occurred in two @entity0 (2%), resulting in serious @entity1 or @entity3 . CONCLUSION: Endovascular treatment of @entity8 with GDCs has low morbidity, and it facilitates good overall outcomes in @entity0 after @entity7 . The short-term effectiveness of @entity5 in preventing aneurysmal rebleeding was excellent. Durability of the treatment in preventing long-term rebleeding as compared with direct surgical clipping warrants further study. Advances in device technology and technique may improve future outcomes.

title: Guglielmi detachable coil treatment of XXXX : retrospective review of a 10-year single-center experience.

answer: @entity8


abstract: BACKGROUND: @entity3 ( @entity3 ) may provide useful local-regional treatment for @entity7 ( @entity7 ). The purpose of this study was to evaluate the safety and efficacy of @entity3 for @entity7 . METHODS: @entity0 with @entity4 who had radiological features or biopsy-proven @entity7 were included in the study. @entity0 without @entity4 and @entity0 with extrahepatic @entity1 were excluded. The mean age was 62.7 years. The mean @entity2 size was 5.5 cm. Eleven @entity0 had @entity2 , and 46% were within the Milan criteria. @entity0 received 63 Gy delivered over a 3-week period with @entity3 . RESULTS: Seventy-six @entity0 were treated and followed prospectively for treatment outcomes at Loma Linda University Medical Center. Acute @entity6 was minimal; all @entity0 completed the full course of treatment. @entity5 was evaluated using liver enzyme, @entity8 , and albumin levels; no significant change supervened 6 months posttreatment. Median progression-free survival for the entire group was 36 months, with a 60% 3-year progression-free survival rate for @entity0 within the Milan criteria. Eighteen @entity0 subsequently underwent liver transplantation; 6 (33%) explants showed pathological complete response and 7 (39%) showed only microscopic residual. CONCLUSIONS: @entity3 was found to be a safe and effective local-regional therapy for inoperable @entity7 . A randomized controlled trial to compare its efficacy to a standard therapy has been initiated. @entity2 2011.    2011 American @entity2 Society.

title: The safety and efficacy of high-dose proton beam radiotherapy for XXXX : a phase 2 prospective trial.

answer: @entity7


abstract: OBJECTIVE: To explore the indications of arthroscope for the treatment of @entity1 and investigate the correlation between @entity1 imaging and effects of arthroscope. METHODS: From 2005.8 to 2008.4, 86 @entity0 with @entity1 underwent arthroscope examination and treatment. Among the @entity0 , 44 @entity0 were male, and 42 @entity0 were female, ranging in age from 46 to 67 years, averaged 56.3 years. Arthrodial cartilage of knee was graded by ICRS MR, and by Kellgern Laqrence X-ray. All the @entity0 were followed up, and the duration ranged from 12 to 30 months. The Lysholm score was evaluated at the follow-up time. RESULTS: Among 86 knees in 86 cases, @entity2 degree of knees was graded as follows: grade 4 in 30 cases, grade 3 in 22 cases, grade 2 in 20 cases, grade 1 in 12 cases, grade 0 in 2 cases, mean grade (2.77 +/- 1.138). Postoperative Lysholm score ranged from 59 to 100, averaged (95.17 +/- 7.556), Kendall's correlation coefficient was -0.089, P = 0.317. There was no correlations between @entity2 degree and Lysholm score. X-ray of knees was graded as follows: grade 4 in 0 cases, grade 3 in 24 cases, grade 2 in 38 cases, grade 1 in 17 cases, grade 0 in 7 cases, mean grade was (2.13 +/- 0.67), the Kendall's correlation coefficient was -0.851 with negative correlations (P = 0.036) between postoperative Lysholm score and K/L grade. CONCLUSION: There is no correlation between the grade of knee @entity2 confirmed by MRI (1.5T) and effects of arthroscopy, and the grade is not a gold standard as an operation indication in arthroscope procedure. The K/L grade in X-ray had important effects.

title: [Study on the correlation between XXXX imaging and effects of arthroscope].

answer: @entity1


abstract: The aim of this study was the quantitative assessment of the time course and spatial distribution in brain of invading @entity4 ( @entity4 ) cells using a recently described model consisting of @entity1 @entity1 @entity4 cells stably transfected with enhanced green fluorescent protein (eGFP) - called RT2-eGFP - and implanted in Fischer @entity1 . Invasion throughout the brain was verified by confocal microscopy and immunocytochemical staining for eGFP. @entity1 were sacrificed on post-implantation days 3, 8, and @entity3 ( @entity3 ). First, the entire @entity1 brain was disaggregated at each time point and viable @entity1 -eGFP cells were counted using flow cytometry with fluorescence as the marker. Next, 2 mm(3) samples of cortex from each of four brain quadrants (bifrontal and bioccipital) were disaggregated at each time point, with @entity0 cell quantification as before. @entity0 cell density, averaged over the entire brain, reached a peak mid-way through its time course, leveling out by @entity3 . @entity0 cell density within @entity0 ( @entity0 ) was greatest early in the evolution of the @entity5 , decreasing to its final value mid-way through its time course, due to @entity2 . The greatest concentration of @entity0 cells was within @entity0 , with up to an order of magnitude fewer cells in the periphery, while the number of @entity5 cells invading brain distant from @entity0 remained constant from day 3 until @entity3 . @entity0 size steadily increased after implantation, with an increasing portion due to central @entity2 as time progressed, suggesting that this effect is an important contributor to fatality in this model. Alternatively (or additionally), accumulation of toxins elaborated by @entity0 cells throughout the brain starting early in the evolution of the @entity0 may also contribute to fatality.

title: Quantitative assessment of XXXX invasion in vivo.

answer: @entity4


abstract: OBJECTIVE: Most studies on @entity0 with severe @entity5 (SBI) are based on data from specialized centres. This prospective epidemiologic study included all @entity0 in a defined region with a @entity4 lasting more than 24 hours or leading to a @entity3 . METHODS: All @entity0 with a SBI admitted to an emergency department in the region were included during a 1-year period. A data form was completed with initial neurological state, CT scan lesions and associated injuries. Outcome at the end of acute hospitalization was assessed from medical notes. RESULTS: Two hundred and forty-eight @entity0 were registered. Annual incidence was 8.5/100 000 population. Median age was 41 years. Traffic crashes were the most frequent cause (59%). Falls occurred in 30% (16% from a high level, 14% from one level). Initial GCS was above 8 in 31%, and @entity0 with a @entity1 were older (52 vs 32 years). @entity3 occurred in 52% of the cohort. Outcome was related to CT scan diagnosis, delay before eye opening and delay before obeying commands. CONCLUSION. This population-based cohort of @entity0 with SBI was different from @entity0 selected in @entity2 centres. The @entity0 were older, more often injured in falls and their mortality rate remained very high.

title: Epidemiology of XXXX : a prospective population-based study.

answer: @entity4


abstract: OBJECTIVE: The cost of radical prostatectomy (RP) compared to watchful waiting (WW) has never been estimated in a randomized trial. The goal of this study was to estimate long-term total costs per @entity0 associated with RP and WW arising from inpatient and outpatient hospital care. MATERIAL AND METHODS: This investigation used the Scandinavian @entity2 Group Study Number 4 (SPCG-4) trial, comparing RP to WW, and included data from 212 @entity0 living in two counties in Sweden from 1989 to 1999 (105 randomized to WW and 107 to RP). All costs were included from randomization date until @entity1 or end of follow-up in July 2007. Resource use arising from inpatient and outpatient hospital costs was measured in physical units and multiplied by a unit cost to come up with a total cost per @entity0 . RESULTS: During a median follow-up of 12 years, the overall cost in the RP group was 34% higher (p < 0.01) than in the WW group, corresponding to    6123 in Sweden. The difference was driven almost exclusively by the cost of the surgical procedure. The cost difference between RP and WW was two times higher among @entity0 with low (2-6) than among those with high (7-10) Gleason score. CONCLUSION: In this economic evaluation of RP versus WW of @entity2 in a randomized study, RP was associated with 34% higher costs. This difference, attributed exclusively to the cost of the RP procedure, was not overcome during extended follow-up.

title: Managing XXXX by radical prostatectomy or watchful waiting: Cost analysis of a randomized trial (SPCG-4).

answer: @entity2


abstract: CONTEXT: @entity2 is the most common chronic disease of @entity0 and it disproportionately affects those living in poverty, but the reasons for this are not clear. Passive smoking may be a modifiable risk factor for @entity2 . OBJECTIVE: To examine the relationship between @entity2 and serum @entity3 levels. DESIGN, SETTING, AND @entity0 : Cross-sectional data from the Third National Health and Nutrition Examination Survey (1988-1994) of 3531 @entity0 aged 4 to 11 years, who had had both dental examinations and a serum @entity3 level measurement. MAIN OUTCOME MEASURES: Passive smoking defined as serum @entity3 levels of 0.2 to 10 ng/mL and caries defined as decayed (unfilled) or filled tooth surfaces. RESULTS: Twenty-five percent of the @entity0 had at least 1 unfilled decayed tooth surface and 33% had at least 1 filled surface. Fifty-three percent had @entity3 levels consistent with passive smoking. Elevated @entity3 level was significantly associated with both decayed (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.5-2.9) and filled (OR, 1.4; 95% CI, 1.1-1.8) tooth surfaces in deciduous but not in permanent teeth. This relationship persisted after adjusting for age, sex, race, family income, geographic region, frequency of dental visits, and blood lead level. For @entity2 in deciduous teeth, the adjusted OR was 1.8 (95% CI, 1.2-2.7) for the risk of decayed surfaces and 1.4 (95% CI, 1.1-2.0) for filled surfaces. We estimated the population attributable risk from passive smoking to be 27% for decayed and 14% for filled tooth surfaces. CONCLUSIONS: There is an association between environmental @entity1 smoke and risk of caries among @entity0 . Reduction of passive smoking is important not only for the prevention of many medical problems, but also for the promotion of @entity0 's dental health.

title: Association of pediatric XXXX with passive smoking.

answer: @entity2


abstract: The hemodynamic effects of an intravenous dose of 1 mg/kg of @entity7 , a new anti-arrhythmic agent with properties of classes I, III and IV of the Vaughan-Williams classification, were studied in 9 @entity0 during routine cardiac catheterization. Six @entity0 had @entity3 ( @entity2 in 5 and @entity6 in 1), one @entity0 had @entity4 , one @entity0 had @entity8 and the remaining @entity0 had @entity5 of the thoracic aorta. Left ventricular pressure and right sided intracardiac pressures were recorded using a high fidelity transduced and a Swan-Ganz catheter respectively. The first derivative of the left ventricular pressure was obtained electronically and Vmax calculated by linear extrapolation to zero load of the contractile element shortening velocity--left ventricular pressure relationship. Plasma levels of @entity7 were measured by gas liquid chromatography. All these parameters were obtained under baseline conditions and then 5, 10, 20, 40 and 60 minutes after intravenous administration of @entity7 . Cardiac index fell by 20% 5 minutes after the injection of @entity7 , and returned to control after one hour only. This fall was primarily related to a decrease in @entity1 index, since heart rate remained virtually unchanged. Right and left ventricular filling pressures increased significantly from the 5th to the 40th minute. Aortic systolic pressure fell by approximately 6%, without any change in mean and diastolic aortic pressures. Peripheral and pulmonary resistances increased at 20 minutes by 33% and 45%, respectively. Left ventricular peak positive dP/dt and Vmax decreased significantly at 5 minutes and remained below the baseline value until 60 minutes by 9% and 11% respectively. Percent changes in cardiac index, dP/dt and Vmax were significantly correlated to @entity7 plasma levels (r = 0.85, 0.79, 0.74 respectively; n = 45). Thus, doses achieving plasma levels within the reported therapeutic range (250-350 ng/ml) would be expected to result in a 8-12% decrease in cardiac output associated with 12-17% and 15-21% reduction of left ventricular dP/dt and Vmax respectively. These data indicate that @entity7 exerts significant negative inotropic effects. Its use in the subset of @entity0 with severely depressed ventricular function warrants caution.

title: Hemodynamic effects of a new antiarrhythmic agent: XXXX .

answer: @entity7


abstract: The COP9 signalosome (CSN) is a multi-protein complex that regulates the activities of cullin-RING E3 ubiquitin ligases (CRLs). CRLs ubiquitinate proteins in order to target them for proteasomal degradation. The CSN is required for proper plant development. Here we show that the CSN also has a profound effect on plant defense responses. Silencing of genes for CSN subunits in @entity0 plants resulted in a mild morphological phenotype and reduced expression of wound-responsive genes in response to mechanical wounding, attack by @entity2 larvae, and Prosystemin over-expression. In contrast, expression of pathogenesis-related genes was increased in a stimulus-independent manner in these plants. The reduced wound response in CSN-silenced plants corresponded with reduced synthesis of @entity3 (JA), but levels of @entity1 (SA) were unaltered. As a consequence, these plants exhibited reduced resistance against herbivorous @entity2 larvae and the necrotrophic fungal pathogen @entity4 . In contrast, susceptibility to @entity5 ) was not altered in CSN-silenced plants. These data demonstrate that the CSN orchestrates not only plant development but also JA-dependent plant defense responses.

title: The COP9 signalosome controls XXXX synthesis and plant responses to herbivory and pathogens.

answer: @entity3


abstract: Emergency transcutaneous @entity1 was studied prospectively in 19 @entity0 presenting to the emergency department with a @entity2 arrest of 20 minutes duration or less. Pacing was initiated when conventional advanced cardiac life support (including @entity3 administration) and a fluid challenge failed to restore a pulse. Seventeen @entity0 also had placement of transvenous pacemaker electrodes for @entity1 . Transcutaneous @entity1 rapidly established a blood pressure in the two @entity0 who for clinical reasons did not receive a transvenous pacemaker. Five @entity0 were transcutaneously paced within five minutes of @entity2 (Group 1) and the remaining 14 were paced between five and 20 minutes following @entity2 (Group 2). Two of the Group 1 @entity0 were admitted and subsequently recovered full neurological and prearrest cardiac function. Fewer Group 2 @entity0 developed a blood pressure (P = .04), and there were no @entity0 with full neurologic recovery in this group (P = .06). Similar results were found for transvenous @entity1 ; there was a greater incidence of a palpable pulse and measurable blood pressure (P = .05 for both) in the Group 1 @entity0 than in the Group 2 @entity0 . No difference in clinical outcome was noted between the two pacing techniques. These results support the concept that @entity1 must be initiated early if the outcome of bradyasystolic @entity2 is to be altered.

title: Transcutaneous and transvenous @entity1 for early bradyasystolic XXXX .

answer: @entity2


abstract: Emergency transcutaneous @entity1 was studied prospectively in 19 @entity0 presenting to the emergency department with a @entity2 arrest of 20 minutes duration or less. Pacing was initiated when conventional advanced cardiac life support (including @entity3 administration) and a fluid challenge failed to restore a pulse. Seventeen @entity0 also had placement of transvenous pacemaker electrodes for @entity1 . Transcutaneous @entity1 rapidly established a blood pressure in the two @entity0 who for clinical reasons did not receive a transvenous pacemaker. Five @entity0 were transcutaneously paced within five minutes of @entity2 (Group 1) and the remaining 14 were paced between five and 20 minutes following @entity2 (Group 2). Two of the Group 1 @entity0 were admitted and subsequently recovered full neurological and prearrest cardiac function. Fewer Group 2 @entity0 developed a blood pressure (P = .04), and there were no @entity0 with full neurologic recovery in this group (P = .06). Similar results were found for transvenous @entity1 ; there was a greater incidence of a palpable pulse and measurable blood pressure (P = .05 for both) in the Group 1 @entity0 than in the Group 2 @entity0 . No difference in clinical outcome was noted between the two pacing techniques. These results support the concept that @entity1 must be initiated early if the outcome of bradyasystolic @entity2 is to be altered.

title: Transcutaneous and transvenous XXXX for early bradyasystolic @entity2 .

answer: @entity1