abstract: 1. Serum and lipoprotein @entity0 and @entity2 were measured before, during and after the administration of @entity4 (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided by significant rises in @entity3 excretion and antipyrine clearance. 3. Concentrations of total serum @entity0 , very-low-density-lipoprotein-, low-density-lipoprotein and high-density-lipoprotein- @entity0 rose significantly during treatment. 4. The time course of these changes was delayed in comparison with the rise and fall in @entity3 excretion. 5. There was no change in the @entity1 content of either whole serum or lipoprotein fractions at any time during the trial. 6. The study provides further evidence that enzyme-inducing agents cause a rise in certain lipid concentrations.

title: Enzyme induction and serum and lipoprotein lipids: a study of XXXX in normal subjects.

answer: @entity4


abstract: The influence of @entity4 ( @entity10 ) on the aggregation of @entity7 ( @entity7 ) was examined by means of in vitro aggregometry as well as in an in vivo model of @entity1 ( @entity1 ). The @entity10 caused a dose-dependent aggregation of @entity7 that was partially blocked by addition of serum to the drug prior to its reaction with the @entity7 . No aggregation of @entity7 was seen after the addition of @entity9 , a similar polyene antibiotic. In vivo studies were conducted in @entity0 , where @entity1 was induced by an intravenous infusion of zymosan-activated plasma (ZAP) or @entity5 ( @entity6 ), and the degree of resulting @entity8 was expressed as the number of @entity7 per @entity3 ( @entity3 ). Animals in the control group had 6 +/- 3 @entity7 / @entity3 . This number increased to 12.4 +/- 5.6 when ZAP was infused and postmortem examination was performed 1 h later and to 17.4 +/- 4 if the examination was performed after 24 h. These numbers increased more than twice when @entity10 (1 mg/kg) was infused together with the ZAP. Increased @entity1 after the infusion of ZAP and @entity10 was not attenuated by prior administration of @entity2 (30 mg/kg) to the animals. Infusions of @entity10 per se caused no significant @entity1 but did cause increased pinocytosis in the pulmonary endothelium. Enhancement of @entity1 by @entity10 was also examined in a model of PMA-induced @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity4 causes aggregation of neutrophils and enhances XXXX .

answer: @entity1


abstract: The influence of @entity4 ( @entity10 ) on the aggregation of @entity7 ( @entity7 ) was examined by means of in vitro aggregometry as well as in an in vivo model of @entity1 ( @entity1 ). The @entity10 caused a dose-dependent aggregation of @entity7 that was partially blocked by addition of serum to the drug prior to its reaction with the @entity7 . No aggregation of @entity7 was seen after the addition of @entity9 , a similar polyene antibiotic. In vivo studies were conducted in @entity0 , where @entity1 was induced by an intravenous infusion of zymosan-activated plasma (ZAP) or @entity5 ( @entity6 ), and the degree of resulting @entity8 was expressed as the number of @entity7 per @entity3 ( @entity3 ). Animals in the control group had 6 +/- 3 @entity7 / @entity3 . This number increased to 12.4 +/- 5.6 when ZAP was infused and postmortem examination was performed 1 h later and to 17.4 +/- 4 if the examination was performed after 24 h. These numbers increased more than twice when @entity10 (1 mg/kg) was infused together with the ZAP. Increased @entity1 after the infusion of ZAP and @entity10 was not attenuated by prior administration of @entity2 (30 mg/kg) to the animals. Infusions of @entity10 per se caused no significant @entity1 but did cause increased pinocytosis in the pulmonary endothelium. Enhancement of @entity1 by @entity10 was also examined in a model of PMA-induced @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX causes aggregation of neutrophils and enhances @entity1 .

answer: @entity4


abstract: INTRODUCTION: Many @entity0 with @entity1 receive integrative medicine in China, which includes the basic treatment of Western medicine and routine rehabilitation, in conjunction with acupuncture and Chinese medicine. The question of whether integrative medicine is efficacious for @entity1 rehabilitation is still controversial and very little research currently exists on the integrated approach for this condition. Consequently, we will conduct a multicentre, randomised, controlled, assessor-blinded clinical trial to assess the effectiveness of integrative medicine on @entity1 rehabilitation. METHODS AND ANALYSIS: 360 @entity0 recruited from three large Chinese medical hospitals in Zhejiang Province will be randomly divided into the integrative medicine rehabilitation (IMR) group and the conventional rehabilitation (CR) group in a 1:1 ratio. @entity0 in the IMR group will receive acupuncture and Chinese herbs in addition to basic Western medicine and rehabilitation treatment. The CR group will not receive acupuncture and Chinese herbal medicine. The assessment data will be collected at baseline, 4 and 8   weeks postrandomisation, and then at 12   weeks' follow-up. The primary outcome is measured by the Modified Barthel Index. The secondary outcomes are the National Institutes of Health @entity1 Scale (NIHSS), Fugl-Meyer Assessment, the mini-mental state examination and Montreal Cognitive, Hamilton's @entity2 Scale and Self-Rating @entity2 Scale, and the incidence of adverse events. ETHICS AND DISSEMINATION: Ethical approval was obtained from ethics committees of three hospitals. The results will be disseminated in a peer-reviewed journal and presented at international congresses. The results will also be disseminated to @entity0 by telephone, during follow-up calls inquiring on @entity0 's post-study health status. TRIAL REGISTRATION NUMBER: Chinese Clinical Trial Register: ChiCTR-TRC-12001972, http://www.chictr.org/en/proj/show.aspx?proj=2561.

title: Integrative medicine for subacute XXXX rehabilitation: a study protocol for a multicentre, randomised, controlled trial.

answer: @entity1


abstract: BACKGROUND: Calcific @entity2 affects 10%-15% of the elderly population, causing considerable morbidity and mortality. There is no imaging technique that allows for the assessment of tissue composition of the valve in  vivo. We thus investigated whether multiparametric magnetic resonance imaging (MRI) could characterize and quantify lipid, fibrous, and mineralized tissues within aortic valve (AV) cusps. METHODS: AV leaflets were explanted from @entity0 with severe @entity1 at the time of valve replacement surgery. Aortic cusps were imaged ex  vivo using 1.5T MRI using 3 gradient-echo sequences with T1, moderate T2, and proton density weightings (T1w, T2w, and PDw). Histopathologic analysis was performed on coregistered slices to identify and measure mineralized tissue, fibrous tissue, and lipid-rich tissue. Area and mean grey values were measured in @entity3 weightings by standardized software. RESULTS: Four hundred ninety-two regions of interest from 30 AV leaflets were studied. Total leaflet surface and the areas of mineralized (P < 0.0001), fibrous (P  = 0.002), and lipid-rich (P  = 0.0001) tissues measured by MRI matched closely those measured by histopathologic examination. @entity3 weightings provided significant discrimination between median grey values for mineralized, fibrous, and lipid-rich tissues (P < 0.0001 for T1w, moderate T2w, and PDw). A best-fit equation integrating the grey value data from @entity3 weightings allowed multiparametric MRI to identify valve leaflet components with areas under the receiver operating characteristic curve of 0.92, 0.81, and 0.72, respectively. CONCLUSIONS: AV leaflet characteristics, including tissue composition, distribution, and area, may be successfully measured by multiparametric MRI with good to excellent accuracy.

title: Valve tissue characterization by magnetic resonance imaging in calcific XXXX .

answer: @entity2


abstract: Current guideline-based recommendations for oral dual-antiplatelet therapy in an @entity3 ( @entity3 ) include the use of newer @entity2 receptor inhibitor ( @entity2 ri) regimens and agents. The Canadian @entity3 Reflective Program is a multicenter observational quality-enhancement project that compared the use of @entity2 ri therapy in 2 phases (November 2011-March 2013 and April 2013-November 2013) and also compared ADPri use with previous national data from the Canadian Global Registry of Acute Coronary Events (2000-2008). Of 3099 @entity0 with @entity3 , 30.6% had @entity1 ( @entity1 ), 52.3% had non- @entity1 , and 17% had @entity5 . There was high use of dual-antiplatelet therapy for  <= 24 hours, with important increases noted when compared with previous national experience (P for trend, < 0.0001). @entity4 was the most commonly used @entity2 ri (82.2%), with lower use of the newer agents @entity7 (9.0%) and @entity6 (3.1%). Ticagrelor and @entity6 use was most frequent in @entity0 with @entity1 undergoing percutaneous coronary intervention PCI (34.3%). There was relatively lower use of @entity2 ri therapy at discharge; it was given mainly to @entity0 who did not undergo PCI (68.2%) and to those with non-ST-elevation @entity3 (82%). When comparing the 2 consecutive phases of data collection in the @entity3 Reflective, there was an approximate 3- and 2-fold increase in the early and discharge use of the newer ADPri agents, respectively. In conclusion, there has been a temporal increase in ADPri use compared with previous national experience and an increased uptake of newer @entity2 ri agents. Additional work is needed to identify and address barriers limiting optimal implementation of these newer guideline-recommended agents into routine Canadian practice.

title: Increased uptake of guideline-recommended oral antiplatelet therapy: insights from the canadian XXXX reflective.

answer: @entity3


abstract: Fifty-six blunt @entity7 @entity0 (HTI-ISS 22-57) were studied for the effects of immediate versus delayed internal fixation of a femur or acetabular @entity2 on the @entity4 septic state. The @entity4 septic state may be defined as an alveolar arterial @entity1 tension difference greater than 100, plus @entity3 and @entity5 . These @entity0 were divided into four groups. Group I (N = 20) had immediate internal fixation, postoperative ventilatory support, and was sitting up at 30 hours. Group II (N = 20) had 10 days of femur traction and postoperative ventilatory support. Group III (N = 9) was immediately extubated after surgery and had 30 days of femur traction. Group IV (N = 7) had special circumstances that should increase the duration of the @entity4 septic state. These four groups of @entity0 were statistically identical by 20 different criteria on admission except that Group I had more recognized chest injuries than Group II (12 vs. 9). Group I required 3.4 +/- 2.6 days of ventilator support and 7.5 +/- 3.8 intensive care unit (ICU) days; they had 12 +/- 8.8 elevated white counts, 3.8 +/- 4 febrile days, 0.05 positive blood cultures per @entity0 , four @entity2 complications out of 93 @entity2 , 59 injections of narcotics, and 23 +/- 8.6 acute care days. Ten days of femur traction doubled the duration of the @entity4 septic state relative to Group I at a statistically significant level for nine out of 10 criteria, while increasing the number of positive blood cultures by a factor of 10, the number of @entity2 complications by a factor of 3.5, and the use of injectable narcotics by a factor of 2. Thirty days of femur traction increased the duration of the @entity4 septic state relative to Group I by a factor of 3 to 5 for all criteria at a statistically significant level, while increasing @entity2 complications by a factor of 17, positive blood cultures by a factor of 74, and the use of narcotics by a factor of 2. Group IV, which had four out of seven immediate internal fixations, behaved similarly to Group II. Femoral shaft traction should be avoided in the blunt @entity7 @entity0 because it greatly increases the cost of care and the risk of @entity6 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: Blunt @entity7 (ISS 36), femur traction, and the XXXX -septic state.

answer: @entity4


abstract: Fifty-six blunt @entity7 @entity0 (HTI-ISS 22-57) were studied for the effects of immediate versus delayed internal fixation of a femur or acetabular @entity2 on the @entity4 septic state. The @entity4 septic state may be defined as an alveolar arterial @entity1 tension difference greater than 100, plus @entity3 and @entity5 . These @entity0 were divided into four groups. Group I (N = 20) had immediate internal fixation, postoperative ventilatory support, and was sitting up at 30 hours. Group II (N = 20) had 10 days of femur traction and postoperative ventilatory support. Group III (N = 9) was immediately extubated after surgery and had 30 days of femur traction. Group IV (N = 7) had special circumstances that should increase the duration of the @entity4 septic state. These four groups of @entity0 were statistically identical by 20 different criteria on admission except that Group I had more recognized chest injuries than Group II (12 vs. 9). Group I required 3.4 +/- 2.6 days of ventilator support and 7.5 +/- 3.8 intensive care unit (ICU) days; they had 12 +/- 8.8 elevated white counts, 3.8 +/- 4 febrile days, 0.05 positive blood cultures per @entity0 , four @entity2 complications out of 93 @entity2 , 59 injections of narcotics, and 23 +/- 8.6 acute care days. Ten days of femur traction doubled the duration of the @entity4 septic state relative to Group I at a statistically significant level for nine out of 10 criteria, while increasing the number of positive blood cultures by a factor of 10, the number of @entity2 complications by a factor of 3.5, and the use of injectable narcotics by a factor of 2. Thirty days of femur traction increased the duration of the @entity4 septic state relative to Group I by a factor of 3 to 5 for all criteria at a statistically significant level, while increasing @entity2 complications by a factor of 17, positive blood cultures by a factor of 74, and the use of narcotics by a factor of 2. Group IV, which had four out of seven immediate internal fixations, behaved similarly to Group II. Femoral shaft traction should be avoided in the blunt @entity7 @entity0 because it greatly increases the cost of care and the risk of @entity6 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: Blunt XXXX (ISS 36), femur traction, and the @entity4 -septic state.

answer: @entity7


abstract: BACKGROUND: Previous studies have reported @entity1 to be the most common reason for revision hip arthroscopy. An awareness of the most frequent locations of the @entity1 may be critical to minimize these failures. QUESTIONS/PURPOSES: The purposes of this study were to (1) define the three-dimensional (3-D) morphology of hips with residual symptoms before revision femoroacetabular impingement (FAI) surgery; (2) determine the limitation in range of motion (ROM) in these @entity0 using dynamic, computer-assisted, 3-D analysis; and (3) compare these measures with a cohort of @entity0 who underwent successful arthroscopic surgery for FAI by a high-volume hip arthroscopist. METHODS: Between 2008 and 2013, one senior surgeon ( @entity3 ) performed revision arthroscopic FAI procedures on @entity0 with residual FAI @entity1 after prior unsuccessful arthroscopic surgery; all of these 47 @entity0 (50 hips) had preoperative CT scans. Mean @entity0 age was 29    9 years (range, 16-52 years). Three-dimensional models of the hips were created to allow measurements of femoral and acetabular morphology and ROM to bony impingement using a validated, computer-based dynamic imaging software. During the same time period, 65 @entity0 with successful primary arthroscopic treatment of FAI by the same surgeon underwent preoperative CT scans for the symptomatic contralateral hip; this group of 65 @entity0 thus fortuitously provided postoperative evaluation of the originally operated hip and served as a control group. A comparison of the virtual correction with the actual correction in the primary successful FAI treatment cohort was performed. Correspondingly, a comparison of the recommended virtual correction with the correction evident at the time of presentation after failed primary surgery in the revision cohort was performed. Analysis was performed by two independent observers (JRR, @entity2 ) and a paired t-test was used for comparison of continuous variables, whereas chi-square testing was used for categorical variables with p < 0.05 defined as significant. RESULTS: Ninety percent (45 of 50) of @entity0 undergoing revision surgery for symptomatic FAI had @entity1 ; the mean maximal alpha angle in revision hips was 68      16   and was most often located at 1:15, considering the acetabulum as a clockface and 1 to 5 o'clock as anterior independent of side. Twenty-six percent (13 of 50) of hips had signs of overcoverage with a lateral center-edge angle greater than or equal to 40  . Dynamic analysis revealed mean direct hip flexion of 114      11   to osseous impingement. Internal rotation in 90   of hip flexion and flexion, adduction, internal rotation to osseous contact were 28      12   and 20      10  , respectively, which were less than those in hips that had underwent hip arthroscopy by a high-volume hip arthroscopist (all p < 0.001). CONCLUSIONS: We found marked radiographic evidence of @entity1 in @entity0 with residual symptoms compared with @entity0 with successful results with @entity1 present in the large majority of @entity0 (45 of 50 [90%]) undergoing residual FAI surgery. We recommend careful attention to full 3-D resection of impinging structures.

title: XXXX is the most common reason for revision hip arthroscopy: a three-dimensional CT study.

answer: @entity1


abstract: BACKGROUND: Cardiovascular magnetic resonance (CMR) derived native myocardial T1 is decreased in @entity0 with @entity2 even before @entity3 ( @entity3 ) occurs and may be the first non-invasive measure of myocyte sphingolipid storage. The relationship of native T1 lowering prior to @entity1 and other candidate early phenotype markers are unknown. Furthermore, the reproducibility of T1 mapping has never been assessed in @entity2 . METHODS: Sixty-three @entity0 , 34 (54%) female, mean age 48  15 years with confirmed (genotyped) @entity2 underwent CMR, ECG and echocardiographic assessment. @entity3 was absent in 25 (40%) @entity0 . Native T1 mapping was performed with both Modified Look-Locker Inversion recovery (MOLLI) sequences and a shortened version (ShMOLLI) at 1.5 Tesla. Twenty-one @entity0 underwent a second scan within 24 hours to assess inter-study reproducibility. Results were compared with 63 healthy age and gender-matched volunteers. RESULTS: Mean native T1 in @entity2 ( @entity3 positive), ( @entity3 negative) and healthy volunteers was 853  50 ms, 904  46 ms and 968  32 ms (for all p<0.0001) by ShMOLLI sequences. Native T1 showed high inter-study, intra-observer and inter-observer agreement with intra-class correlation coefficients (ICC) of 0.99, 0.98, 0.97 (ShMOLLI) and 0.98, 0.98, 0.98 (MOLLI). In @entity2 @entity3 negative individuals, low native T1 was associated with reduced echocardiographic-based global longitudinal speckle tracking strain (-18  2% vs -22  2%, p=0.001) and early diastolic function impairment (E/E'=7 [6-8] vs 5 [5-6], p=0.028). CONCLUSION: Native T1 mapping in @entity2 is a reproducible technique. T1 reduction prior to the onset of @entity3 is associated with early diastolic and systolic changes measured by echocardiography.

title: Reproducibility of native myocardial T1 mapping in the assessment of XXXX and its role in early detection of cardiac involvement by cardiovascular magnetic resonance.

answer: @entity2


abstract: Objective: This article describes the diagnosis, clinical and microscopic (histopathology and ultrastructural) features and treatment of a new family with @entity6 ( @entity6 ) and highlights the importance of this @entity1 . Study Design: To characterize the pattern of inheritance and the clinical features, members of a new family with @entity6 were examined. The pedigree was reliably constructed including the four latest generations of family. @entity2 and @entity3 staining and ultrastructural analysis were performed with the gingival tissue. Results: Examination of the family pedigree revealed that the @entity0 III-2 represent the index @entity0 of this family (initial @entity0 with a mutation), which was transmitted to her daughter through an autosomal dominant mode of inheritance. The affected @entity0 showed a generalized @entity4 . The @entity0 was treated with surgical procedures of gingivectomy and gingivoplasty. The diagnosis was confirmed by histopathology examination that showed a well-structured epithelium with @entity5 inserted in fibrous connective tissue with increased amount of collagen. The ultrastructural aspects of the tissue show collagen fibrils exhibiting their typically repeating banding pattern with some fibrils displaying loops at their end. Moreover, it was possible to seen in some regions fibrillar component presenting tortuous aspects and loss of the alignment among them. Conclusions: This @entity6 frequently resulted in both esthetic and functional problems. The genetic pattern of this Brazilian family suggested a new mutation, which was later transmitted by an autosomal dominant trait.

title: XXXX : Clinical and ultrastructural features of a new family.

answer: @entity6


abstract: Methanotrophs are crucial in regulating @entity0 emission from @entity1 field systems. Type II methanotrophs in particular are often observed in high abundance in paddy soil. Some cultivated species of Methylocystis are able to grow on @entity2 in the absence of @entity0 . We hypothesize that the dominant type II methanotrophs in paddy soil might facultatively utilize @entity2 for growth, which we evaluate in the present study. The measurement of @entity0 oxidation rates showed that the methanotrophic activity in paddy soil was inhibited by the addition of @entity2 compared to the continuous supplementation of @entity0 , but the paddy soil maintained the @entity0 oxidation capacity and recovered following @entity0 supplementation. Terminal restriction fragment length polymorphism analysis (T-RFLP) combined with cloning and sequencing of pmoA genes showed that Methylocystis was enriched after incubation with added @entity2 , while the type I methanotrophs Methylocaldum/Methylococcus and Methylobacter were enriched by @entity0 supplementation. A comparison of pmoA sequences obtained in this study with those in the public database indicated that they were globally widespread in paddy soils or in associated with @entity1 roots. Furthermore, we performed stable isotope probing (SIP) of pmoA messenger RNA (mRNA) to investigate the assimilation of (13)C-acetate by paddy soil methanotrophs. RNA-SIP revealed that Methylocystis-related methanotrophs which shared the same genotype of the above enriched species were significantly labelled. It indicates that these methanotrophs actively assimilated the labelled @entity2 in paddy soil. Altogether, these results suggested that uncultivated Methylocystis species are facultative methanotrophs utilizing @entity2 as a secondary carbon source in paddy soil.

title: Uncultivated Methylocystis Species in Paddy Soil Include Facultative Methanotrophs that Utilize XXXX .

answer: @entity2


abstract: INTRODUCTION: Breakfast is considered the most important meal of the day in an equilibrated diet. Skipping breakfast has been associated with @entity3 . This study aimed to describe @entity3 and @entity1 among high school students in Barcelona and to analyze their association with eating habits and @entity2 . MATERIAL AND METHODS: A cross-sectional study was performed in 2008 on a representative sample of high-school students in Barcelona (Spain). Overweight and @entity1 were defined using Body Mass Index (BMI), which was calculated from objective measurements. The prevalences of @entity3 and @entity1 were determined, and their association with eating habits, @entity2 , and physical activity was analyzed using logistic regression models. RESULTS: A total of 3,089 students were analyzed (52% @entity0 ). The prevalence of @entity3 was 26.1% in @entity0 (6.2% obese) and 20.6% in @entity0 (3.7% obese). In both sexes, @entity3 was associated with being younger, having breakfast less often, being on a diet, and with a lower frequency of unhealthy food intake. Being on a diet and a lower unhealthy food intake were related to @entity1 in both sexes. Among @entity0 , @entity1 was also associated with @entity2 . CONCLUSIONS: The results show that @entity3 and @entity1 are a serious public health problem and confirm the importance of breakfast to prevent @entity3 . Moreover, these results allow us to expand our knowledge on the factors associated with @entity3 and @entity1 in order to improve current school preventive programs.

title: [Eating habits, @entity2 and XXXX among adolescents in Barcelona (Spain)].

answer: @entity1


abstract: INTRODUCTION: Breakfast is considered the most important meal of the day in an equilibrated diet. Skipping breakfast has been associated with @entity3 . This study aimed to describe @entity3 and @entity1 among high school students in Barcelona and to analyze their association with eating habits and @entity2 . MATERIAL AND METHODS: A cross-sectional study was performed in 2008 on a representative sample of high-school students in Barcelona (Spain). Overweight and @entity1 were defined using Body Mass Index (BMI), which was calculated from objective measurements. The prevalences of @entity3 and @entity1 were determined, and their association with eating habits, @entity2 , and physical activity was analyzed using logistic regression models. RESULTS: A total of 3,089 students were analyzed (52% @entity0 ). The prevalence of @entity3 was 26.1% in @entity0 (6.2% obese) and 20.6% in @entity0 (3.7% obese). In both sexes, @entity3 was associated with being younger, having breakfast less often, being on a diet, and with a lower frequency of unhealthy food intake. Being on a diet and a lower unhealthy food intake were related to @entity1 in both sexes. Among @entity0 , @entity1 was also associated with @entity2 . CONCLUSIONS: The results show that @entity3 and @entity1 are a serious public health problem and confirm the importance of breakfast to prevent @entity3 . Moreover, these results allow us to expand our knowledge on the factors associated with @entity3 and @entity1 in order to improve current school preventive programs.

title: [Eating habits, XXXX and @entity1 among adolescents in Barcelona (Spain)].

answer: @entity2


abstract: BACKGROUND _ AIMS: @entity2 ( @entity2 ) has been linked to higher real-life rates of automobile crashes and poor performance in driving simulation studies, but the link between driving simulator performance and real-life automobile crashes has not been clearly established. Furthermore, not all @entity0 with @entity2 are unsafe drivers, but it is unclear how to distinguish them from unsafe drivers. We investigated the link between performance on driving simulators and real-life automobile accidents and traffic violations. We also aimed to identify features of unsafe drivers with @entity1 and evaluated changes in simulated driving skills and @entity2 status after 1 year. METHODS: We performed a study of outpatients with @entity1 (n  = 205; median 55 years old; median model for @entity4 score, 9.5; none with overt @entity2 or @entity3 or illicit drug use within previous 6 months) seen at the Virginia Commonwealth University and McGuire Veterans Administration Medical Center, from November 2008 through April 2014. All @entity0 were given paper-pencil tests to diagnose @entity2 (98 had @entity2 ; 48%), and 163 @entity0 completed a standardized driving simulation. Data were collected on traffic violations and automobile accidents from the Virginia Department of Motor Vehicles and from @entity0 ' self-assessments when they entered the study, and from 73 @entity0 1 year later. @entity0 also completed a questionnaire about @entity3 use and cessation patterns. The driving simulator measured crashes, run-time, road center and edge excursions, and illegal turns during navigation; before and after each driving simulation session, @entity0 were asked to rate their overall driving skills. Drivers were classified as safe or unsafe based on crashes and violations reported on official driving records; simulation results were compared with real-life driving records. Multivariable regression analyses of real-life crashes and violations was performed using data on demographics, @entity1 details, @entity2 status, and @entity3 cessation patterns, at baseline and at 1 year. RESULTS: Drivers categorized as unsafe had more crashes and made more illegal turns on the driving simulator than drivers categorized as safe; a higher proportion of subjects with @entity2 were categorized as unsafe drivers at baseline (16%) than subjects without @entity2 (7%; P  = .02), and at 1-year follow-up (18% vs 0%; P  = .02). @entity3 cessation within <1 year and illegal turns during simulator navigation tasks were associated with real-life automobile crashes and @entity2 in regression analysis; road edge excursions in the simulator were associated with real-life traffic violations. Personal assessment of driving skills improved after each simulation episode. CONCLUSIONS: In a study of 205 @entity0 with @entity1 , we associated results from driving simulation tests with real-life driving records and @entity2 . Traffic safety counseling should focus on @entity0 with @entity1 who recently quit consuming @entity3 and perform poorly on driving simulation.

title: In @entity0 With XXXX , Driving Simulator Performance Is  Associated With Real-life Driving.

answer: @entity1


abstract: BACKGROUND _ AIMS: @entity2 ( @entity2 ) has been linked to higher real-life rates of automobile crashes and poor performance in driving simulation studies, but the link between driving simulator performance and real-life automobile crashes has not been clearly established. Furthermore, not all @entity0 with @entity2 are unsafe drivers, but it is unclear how to distinguish them from unsafe drivers. We investigated the link between performance on driving simulators and real-life automobile accidents and traffic violations. We also aimed to identify features of unsafe drivers with @entity1 and evaluated changes in simulated driving skills and @entity2 status after 1 year. METHODS: We performed a study of outpatients with @entity1 (n  = 205; median 55 years old; median model for @entity4 score, 9.5; none with overt @entity2 or @entity3 or illicit drug use within previous 6 months) seen at the Virginia Commonwealth University and McGuire Veterans Administration Medical Center, from November 2008 through April 2014. All @entity0 were given paper-pencil tests to diagnose @entity2 (98 had @entity2 ; 48%), and 163 @entity0 completed a standardized driving simulation. Data were collected on traffic violations and automobile accidents from the Virginia Department of Motor Vehicles and from @entity0 ' self-assessments when they entered the study, and from 73 @entity0 1 year later. @entity0 also completed a questionnaire about @entity3 use and cessation patterns. The driving simulator measured crashes, run-time, road center and edge excursions, and illegal turns during navigation; before and after each driving simulation session, @entity0 were asked to rate their overall driving skills. Drivers were classified as safe or unsafe based on crashes and violations reported on official driving records; simulation results were compared with real-life driving records. Multivariable regression analyses of real-life crashes and violations was performed using data on demographics, @entity1 details, @entity2 status, and @entity3 cessation patterns, at baseline and at 1 year. RESULTS: Drivers categorized as unsafe had more crashes and made more illegal turns on the driving simulator than drivers categorized as safe; a higher proportion of subjects with @entity2 were categorized as unsafe drivers at baseline (16%) than subjects without @entity2 (7%; P  = .02), and at 1-year follow-up (18% vs 0%; P  = .02). @entity3 cessation within <1 year and illegal turns during simulator navigation tasks were associated with real-life automobile crashes and @entity2 in regression analysis; road edge excursions in the simulator were associated with real-life traffic violations. Personal assessment of driving skills improved after each simulation episode. CONCLUSIONS: In a study of 205 @entity0 with @entity1 , we associated results from driving simulation tests with real-life driving records and @entity2 . Traffic safety counseling should focus on @entity0 with @entity1 who recently quit consuming @entity3 and perform poorly on driving simulation.

title: In XXXX With @entity1 , Driving Simulator Performance Is  Associated With Real-life Driving.

answer: @entity0


abstract: BACKGROUND: @entity3 is present in 20% of @entity7 @entity0 . Current preoperative treatment options, including @entity1 supplementation (FE) and @entity6 ( @entity6 ), are expensive. @entity4 ( @entity5 ) has been adopted as an intraoperative adjunct to decrease @entity2 . Our hypothesis is that @entity5 is a cost-effective treatment compared to FE and @entity6 in anemic @entity0 . METHODS: In this study, a cost analysis was performed, comparing the material costs of @entity5 and packed red blood cells (PRBCs) to the theoretical administration and material costs of FE and @entity6 per standard @entity3 protocol. RESULTS: A total of 243 @entity0 were included in the study. Of this group, 18.5% (45/243) had @entity3 . The rate of transfusion was 6.7% (3/45), and 5 units of PRBCs was transfused. The combined cost of @entity5 and PRBCs was  5317.08. Even assuming a best-case scenario with FE or @entity6 treatment without a postoperative PRBC requirement, the cost of treatment would range from 2 to 17 times more than treatment with @entity5 . An additional 50 units of PRBC (1.1 units per @entity0 ) would need to be transfused for the cost of @entity5 treatment to be equivalent to FE or @entity6 treatment. CONCLUSION: @entity4 is significantly less expensive than FE or @entity6 as a treatment option for @entity7 @entity0 presenting with @entity3 . It is a cost-effective adjunct for limiting transfusion rates in this @entity0 population. We recommend that new @entity3 levels that necessitate preoperative intervention be established.

title: Cost Analysis of XXXX in Anemic Total Joint Arthroplasty @entity0 .

answer: @entity4


abstract: BACKGROUND: @entity3 is present in 20% of @entity7 @entity0 . Current preoperative treatment options, including @entity1 supplementation (FE) and @entity6 ( @entity6 ), are expensive. @entity4 ( @entity5 ) has been adopted as an intraoperative adjunct to decrease @entity2 . Our hypothesis is that @entity5 is a cost-effective treatment compared to FE and @entity6 in anemic @entity0 . METHODS: In this study, a cost analysis was performed, comparing the material costs of @entity5 and packed red blood cells (PRBCs) to the theoretical administration and material costs of FE and @entity6 per standard @entity3 protocol. RESULTS: A total of 243 @entity0 were included in the study. Of this group, 18.5% (45/243) had @entity3 . The rate of transfusion was 6.7% (3/45), and 5 units of PRBCs was transfused. The combined cost of @entity5 and PRBCs was  5317.08. Even assuming a best-case scenario with FE or @entity6 treatment without a postoperative PRBC requirement, the cost of treatment would range from 2 to 17 times more than treatment with @entity5 . An additional 50 units of PRBC (1.1 units per @entity0 ) would need to be transfused for the cost of @entity5 treatment to be equivalent to FE or @entity6 treatment. CONCLUSION: @entity4 is significantly less expensive than FE or @entity6 as a treatment option for @entity7 @entity0 presenting with @entity3 . It is a cost-effective adjunct for limiting transfusion rates in this @entity0 population. We recommend that new @entity3 levels that necessitate preoperative intervention be established.

title: Cost Analysis of @entity4 in Anemic Total Joint Arthroplasty XXXX .

answer: @entity0


abstract: The aim of this study is to verify the level of transmission of @entity4 three years after stopping mass drug treatment in the 7 endemic districts in Togo. The survey was conducted in 2012 in Togo's 7 endemic districts grouped into four evaluation units (EU) using theWHO-recommended @entity1 ( @entity1 ) protocol. @entity0 aged 6-7 years were screened for @entity5 bancofti antigen using the immunochromatographic card (ICT) method. A cluster sampling method was used to select eligible @entity0 in schools as the net primary-school enrolment ratio is greater than or equal to 75% in each of the four EUs. The number of @entity0 and schools to be selected in each EU, the randomization list for the selection of these @entity0 and the critical cut-off number of positive cases not to exceed were automatically generated using the Survey Sample Builder (SSB) tool, (NTD Support Center, Atlanta, Ga, USA). For confirmation, positive cases were subsequently tested for microfilaremia using nocturnal thick blood smear and for filarial antigen using Og4C3 antigen ELISA (TropBio ELISA Kit  , Townsville, Queensland, Australia). An EU is considered to have passed the test successfully (it is assumed that transmission can no longer be sustained), when the number of positive cases is below the critical cut-off number set by the SSB, which is roughly equivalent to 2% prevalence. Of the 1 706 @entity0 surveyed in @entity3 's EU, 1 549 in Binah-Doufelgou's EU, 1 550 in Kozah's EU and the 1 575 in Amou-Haho's EU, 8 (0.46%), 1 (0.08%), 0 (0.00%) and 4 (0.25%) ICT positive cases respectively were detected. The number of positive ICT tests was well below 18, the criticalcut number for each of the 4 EUs. All 13 ICT positive cases tested negative for nocturnal microfilaremia and Og4C3 ELISA. We conclude that all four EU passed the @entity1 with success, and the transmission of @entity5 is no longer likely to be sustained in the 7 endemic districts in Togo 3 years after stopping the @entity2 . A new @entity1 will be carried out in 2015, after which, if the results are still good, the country will submit a dossier to WHO for verification of the elimination of @entity4 .

title: [Lymphatic filariasis XXXX in schools three years after stopping mass drug treatment with albendazole and ivermectine in the 7 endemic districts in Togo.]

answer: @entity1


abstract: @entity3 pollutants are commonly related to cereal products and cause fatal threats in food safety, and therefore require simple and sensitive detection. In this work, quantum-dot (QD) submicrobeads (QBs) were synthesized by encapsulating @entity2 /ZnS QDs using the microemulsion technique. The resultant QBs, with approximately 2800 times brighter luminescence than the corresponding QDs, were explored as novel fluorescent probes in the immunochromatographic assay (ICA) for sensitive and quantitative detection of @entity1 (ZEN) in @entity0 . Various parameters that influenced the sensitivity and stability of QB-based ICA (QB-ICA) were investigated and optimized. The optimal QB-ICA exhibits good dynamic linear detection for ZEN over the range of 0.125ng/mL to 10ng/mL with a median inhibitory concentration of 1.01  0.09ng/mL (n=3). The detection limits for ZEN in a standard solution and real @entity0 sample (dilution ratio of 1:30) are 0.0625ng/mL and 3.6  g/kg, respectively, which is much better than that of a previously reported gold nanoparticle-based ICA method. Forty-six natural @entity0 samples are assayed using both QB-ICA and enzyme-linked immunosorbent assay. The two methods show a highly significant correlation (R(2)=0.92). Nine ZEN-contaminated samples were further confirmed with liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the QB-ICA results also exhibited good agreement with LC-MS/MS method. In brief, this work demonstrates that QB-ICA is capable of rapid, sensitive screening of toxins in food analysis, and shows great promise for point-of-care testing of other analytes.

title: Quantum-DoT submicrobead-based immunochromatographic assay for quantitative and sensitive detection of XXXX .

answer: @entity1


abstract: UNASSIGNED: Since virtually no trials have evaluated the effectiveness of @entity2 ( @entity3 ) in the treatment of spinal cord (SC) @entity1 multiforme (GBM), we conducted a systematic review to evaluate its efficacy. Primary SC GBM is rare. Its management remains unclear, even though treatment guidelines have been established since 2005 for its cranial counterpart. We performed a medical subject heading search with the terms " @entity1 " and "primary @entity4 , intramedullary". We stratified the papers into two groups according to the use of @entity3 , and analyzed survival rates using the Kaplan-Meier method with a two-sided log-rank scale. The @entity3 subgroup contained nine articles and a total of 19 @entity0 with primary SC GBM who were treated with adjuvant @entity3 . The non- @entity3 group consisted of 19 articles including 45 @entity0 who underwent other treatment modalities. The @entity3 subgroup had an overall survival of 16months, compared to the non- @entity3 group with a median overall survival of 10months. The difference between these two groups was not statistically significant (p=0.57). While this review did not demonstrate a statistically significant difference in long term survival between @entity0 with SC GBM treated with @entity3 versus those not treated with @entity3 , a slightly longer survival time was seen in the @entity3 group. The small number of @entity0 is likely a contributing factor to the lack of statistical significance. Our analysis highlights the need for a multi-institutional, prospective, controlled study to evaluate the use of @entity3 in the treatment of SC GBM.

title: Primary spinal cord glioblastoma multiforme treated with XXXX .

answer: @entity2


abstract: Highly sensitive colorimetric detection for @entity14 has been developed using @entity16 (MA) functionalized GNP. The - @entity6 on MA was used to modify GNP surface whereas the other - @entity6 functional group have strong affinity to coordination behavior of @entity14 allowing the selective formation more than other ions. MA-GNPs solution changed from red to blue color after the addition of @entity14 due to @entity5 . The different optical absorption and discriminate of particle size between the MA-GNPs solution with and without @entity14 were characterized by UV-visible spectroscopy and transmission electron microscopy (TEM), respectively. The color intensity as a function of @entity14 concentration gave a linear response in the range of 0.0-10.0  gL(-1) (R(2)=0.990). The detection limit was found at 0.5  gL(-1) by naked eye and can be completed the analysis within 15min. The MA-GNPs aggregated with @entity14 showed high selectivity when was compared to other metal ions ( @entity15 , @entity0 , @entity7 , @entity1 , @entity12 , @entity2 , @entity13 , @entity4 , @entity8 , @entity9 , @entity14 and @entity11 ) and anions (Cl(-), @entity10 and @entity3 ). Our proposed method was also applied for the determination of @entity14 in real drinking water samples from 5 sources. The result of real water samples were not statistically significant different from the standard methods at the 95% confidence level (pair t-test method). Moreover, we evaluated our proposed method for the determination of trace @entity14 concentration in real breast milk samples. The recoveries were acceptable and ranged from 101 to 104% for spiked @entity14 in real breast milk samples. Thus, MA-GNP colorimetric sensing provides a simple, rapid, sensitive, easy-to-use, inexpensive and low detection limit for the monitoring of @entity14 .

title: Highly sensitive colorimetric detection of lead using XXXX functionalized gold nanoparticles.

answer: @entity16


abstract: INTRODUCTION: One of the main issues in @entity7 ( @entity7 ) @entity0 is infection, such as @entity3 ( @entity3 ). Of note, @entity7 @entity0 are susceptible to @entity8 . However, to our knowledge, this @entity1 was rarely reported in @entity7 , particularly diffuse or @entity11 . Therefore, from January 1983 to December 2011, 5,635 @entity0 were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for @entity7 . CASE REPORTS: Four (1.4%) of our @entity7 @entity0 had disseminated @entity3 and were described herein. All of them were female gender, received BCG vaccination and did not have a history of @entity3 household contact. The median of current age at @entity3 diagnosis and the period between @entity7 and @entity3 diagnosis were 17 years old (range 14-20) and 5.5 years (range 2-7), respectively. All @entity0 developed @entity11 during the course of the disease. The median of @entity7 Disease Activity Index 2000 (SLEDAI-2K) was 4 (2-16) and the @entity0 were treated with immunosuppressive agents (glucocorticoid, @entity4 and/or intravenous @entity5 ). Two of them presented @entity2 and @entity3 diagnosis was only established at autopsy, especially with lungs, central nervous system and abdominal involvements. Anti- @entity3 therapy ( @entity9 , @entity6 and @entity10 ) was indicated in the other two @entity3 cases, however they deceased. DISCUSSION: @entity11 is a rare and severe opportunist infection in @entity7 . This study reinforces the importance of routine searches for @entity3 in @entity7 @entity0 .

title: [ @entity11 : a severe opportunistic infection in XXXX @entity0 .]

answer: @entity7


abstract: INTRODUCTION: One of the main issues in @entity7 ( @entity7 ) @entity0 is infection, such as @entity3 ( @entity3 ). Of note, @entity7 @entity0 are susceptible to @entity8 . However, to our knowledge, this @entity1 was rarely reported in @entity7 , particularly diffuse or @entity11 . Therefore, from January 1983 to December 2011, 5,635 @entity0 were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for @entity7 . CASE REPORTS: Four (1.4%) of our @entity7 @entity0 had disseminated @entity3 and were described herein. All of them were female gender, received BCG vaccination and did not have a history of @entity3 household contact. The median of current age at @entity3 diagnosis and the period between @entity7 and @entity3 diagnosis were 17 years old (range 14-20) and 5.5 years (range 2-7), respectively. All @entity0 developed @entity11 during the course of the disease. The median of @entity7 Disease Activity Index 2000 (SLEDAI-2K) was 4 (2-16) and the @entity0 were treated with immunosuppressive agents (glucocorticoid, @entity4 and/or intravenous @entity5 ). Two of them presented @entity2 and @entity3 diagnosis was only established at autopsy, especially with lungs, central nervous system and abdominal involvements. Anti- @entity3 therapy ( @entity9 , @entity6 and @entity10 ) was indicated in the other two @entity3 cases, however they deceased. DISCUSSION: @entity11 is a rare and severe opportunist infection in @entity7 . This study reinforces the importance of routine searches for @entity3 in @entity7 @entity0 .

title: [ XXXX : a severe opportunistic infection in @entity7 @entity0 .]

answer: @entity11


abstract: INTRODUCTION: One of the main issues in @entity7 ( @entity7 ) @entity0 is infection, such as @entity3 ( @entity3 ). Of note, @entity7 @entity0 are susceptible to @entity8 . However, to our knowledge, this @entity1 was rarely reported in @entity7 , particularly diffuse or @entity11 . Therefore, from January 1983 to December 2011, 5,635 @entity0 were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for @entity7 . CASE REPORTS: Four (1.4%) of our @entity7 @entity0 had disseminated @entity3 and were described herein. All of them were female gender, received BCG vaccination and did not have a history of @entity3 household contact. The median of current age at @entity3 diagnosis and the period between @entity7 and @entity3 diagnosis were 17 years old (range 14-20) and 5.5 years (range 2-7), respectively. All @entity0 developed @entity11 during the course of the disease. The median of @entity7 Disease Activity Index 2000 (SLEDAI-2K) was 4 (2-16) and the @entity0 were treated with immunosuppressive agents (glucocorticoid, @entity4 and/or intravenous @entity5 ). Two of them presented @entity2 and @entity3 diagnosis was only established at autopsy, especially with lungs, central nervous system and abdominal involvements. Anti- @entity3 therapy ( @entity9 , @entity6 and @entity10 ) was indicated in the other two @entity3 cases, however they deceased. DISCUSSION: @entity11 is a rare and severe opportunist infection in @entity7 . This study reinforces the importance of routine searches for @entity3 in @entity7 @entity0 .

title: [ @entity11 : a severe opportunistic infection in @entity7 XXXX .]

answer: @entity0


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Stemona @entity11 (ST) is a traditional herbal medicine used for the treatment of various @entity6 in eastern Asia. AIM OF THE STUDY: We investigated the anti-inflammatory effects of a ST water extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in cigarette smoke (CS)-induced @entity3 @entity1 models. MATERIALS AND METHODS: RAW 264.7 macrophages were treated with the ST extract and stimulated by LPS. The expressions of pro-inflammatory mediators were evaluated by using @entity5 (NO) assay, enzyme-linked immunosorbent assay and Western blot analysis. After the C57BL/6 @entity1 were exposed to CS, they were administrated with the ST extract. The accumulated inflammatory cells in the bronchoalveolar lavage fluid (BALF) were counted. Also, real-time polymerase chain reaction and @entity7 and @entity8 staining were performed in lung tissues. RESULTS: The ST extract treatment reduced the production of NO via blocking the expressions of @entity10 and inducible @entity5 synthase protein in RAW 264.7 macrophages. In addition, ST extract treatment decreased the secretions of inflammatory cytokines and regulated NF-kB activation by inhibiting the phosphorylation of @entity12 and the mitogen-activated protein kinase pathway. Also, ST extract administration to @entity1 reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, administration of the ST extract regulated the levels of @entity0 @entity2 factor-a, interleukin (IL)-6, @entity4 , @entity9 and matrix metalloproteinases-12 in the lungs. CONCLUSION: These findings suggested that ST extract @entity3 responses by inhibiting the expression of diverse inflammatory mediators in vivo and in vitro.

title: Stemona XXXX prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro.

answer: @entity11


abstract: UNASSIGNED: The accurate depiction of both biologic and anatomic profiles of @entity1 has long been a challenge in PET imaging. An @entity2 , which is innate in the carcinogenesis of @entity5 ( @entity5 ), frequently complicates the image analysis because of the limitations of @entity3 and maximum standardized uptake values (SUVmax). New PET parameters, metabolic @entity1 volume (MTV) and total lesion glycolysis (TLG), as well as (18)F-fluoro-a-methyltyrosine ((18)F-FAMT), a malignancy-specific @entity4 -based PET radiotracer, are considered more comprehensive in @entity1 image analysis. Here, we showed the substantial effects of the intratumoral inflammatory process on @entity3 uptake and further study the possibility of MTV and TLG to predict both @entity1 biology (proliferation activity) and anatomy (pathologic @entity1 volume). METHODS: @entity3 and (18)F-FAMT PET images from 25 @entity5 @entity0 were analyzed. SUVmax on the @entity1 site was obtained. PET volume computerized-assisted reporting was used to generate a volume of interest to obtain MTV and TLG for @entity3 and total lesion retention (TLR) for @entity6 -FAMT. The whole @entity1 dissected from surgery was measured and sectioned for pathologic analysis of @entity1 @entity2 grade and Ki-67 labeling index. RESULTS: The high SUVmax of @entity3 was related to the high @entity2 grade. The SUVmax ratio of @entity3 to @entity6 -FAMT was higher in inflammatory @entity1 (P < 0.05) whereas the corresponding value in @entity1 with a low @entity2 grade was kept low. All @entity6 -FAMT parameters were correlated with Ki-67 labeling index (P < 0.01). Pathologic @entity1 volume predicted from MTV of @entity6 -FAMT was more accurate (R = 0.90, bias = 3.4    6.42 cm(3), 95% confidence interval = 0.77-6.09 cm(3)) than that of @entity3 (R = 0.77, bias = 8.1    11.17 cm(3), 95% confidence interval = 3.45-12.67 cm(3)). CONCLUSION: @entity3 uptake was overestimated by additional uptake related to the intratumoral inflammatory process, whereas (18)F-FAMT simply accumulated in @entity1 according to @entity1 activity as evaluated by Ki-67 labeling index in @entity5 .

title: Effects of Intratumoral Inflammatory Process on @entity3 Uptake: Pathologic and Comparative Study with 18F-Fluoro-a-Methyltyrosine PET/CT in XXXX .

answer: @entity5


abstract: UNASSIGNED: The accurate depiction of both biologic and anatomic profiles of @entity1 has long been a challenge in PET imaging. An @entity2 , which is innate in the carcinogenesis of @entity5 ( @entity5 ), frequently complicates the image analysis because of the limitations of @entity3 and maximum standardized uptake values (SUVmax). New PET parameters, metabolic @entity1 volume (MTV) and total lesion glycolysis (TLG), as well as (18)F-fluoro-a-methyltyrosine ((18)F-FAMT), a malignancy-specific @entity4 -based PET radiotracer, are considered more comprehensive in @entity1 image analysis. Here, we showed the substantial effects of the intratumoral inflammatory process on @entity3 uptake and further study the possibility of MTV and TLG to predict both @entity1 biology (proliferation activity) and anatomy (pathologic @entity1 volume). METHODS: @entity3 and (18)F-FAMT PET images from 25 @entity5 @entity0 were analyzed. SUVmax on the @entity1 site was obtained. PET volume computerized-assisted reporting was used to generate a volume of interest to obtain MTV and TLG for @entity3 and total lesion retention (TLR) for @entity6 -FAMT. The whole @entity1 dissected from surgery was measured and sectioned for pathologic analysis of @entity1 @entity2 grade and Ki-67 labeling index. RESULTS: The high SUVmax of @entity3 was related to the high @entity2 grade. The SUVmax ratio of @entity3 to @entity6 -FAMT was higher in inflammatory @entity1 (P < 0.05) whereas the corresponding value in @entity1 with a low @entity2 grade was kept low. All @entity6 -FAMT parameters were correlated with Ki-67 labeling index (P < 0.01). Pathologic @entity1 volume predicted from MTV of @entity6 -FAMT was more accurate (R = 0.90, bias = 3.4    6.42 cm(3), 95% confidence interval = 0.77-6.09 cm(3)) than that of @entity3 (R = 0.77, bias = 8.1    11.17 cm(3), 95% confidence interval = 3.45-12.67 cm(3)). CONCLUSION: @entity3 uptake was overestimated by additional uptake related to the intratumoral inflammatory process, whereas (18)F-FAMT simply accumulated in @entity1 according to @entity1 activity as evaluated by Ki-67 labeling index in @entity5 .

title: Effects of Intratumoral Inflammatory Process on XXXX Uptake: Pathologic and Comparative Study with 18F-Fluoro-a-Methyltyrosine PET/CT in @entity5 .

answer: @entity3


abstract: The present paper comprises a review of the literature on chondromyxoid @entity2 (CMF) and a report on nine cases originally classified as CMF, found in a review of all curetted @entity1 at our department from 1955 to 1978. At histologic revaluation only two cases fulfilled the criteria for true CMF, whereas six were classified as other @entity1 and one proved to be a @entity3 . The @entity3 case after recurrence was subjected to more mutilating surgery than would have been necessary if correct diagnosis had been established initially. The other six benign cases were all well and without signs of recurrence 5-11 years after curettage. In one of the two true CMF cases, i.e. in a young @entity0 , there were for 2 years postoperatively radiological signs of a progressive recurrence, which was left without treatment, since the @entity0 was well. Interestingly, radiograms 2 and 11 years postoperatively essentially showed the same picture, indicating spontaneous cessation of the process. @entity2 is an extremely rare lesion. Histologic misinterpretation is not uncommon. In sporadic cases this may have serious implications. It may be questioned whether surgical treatment of CMF in young @entity0 , known to have a high recurrence rate, is mandatory.

title: XXXX . A review of the literature and a report on our own experience.

answer: @entity2


abstract: Background. Auricular point acupressure (APA) is a promising treatment for @entity1 management. Few studies have investigated the physiological mechanisms of APA analgesics. Method. In this pilot randomized clinical trial (RCT), a 4-week APA treatment was used to manage @entity5 ( @entity5 ). Sixty-one @entity0 were randomized into a real APA group (n = 32) or a sham APA group (n = 29). Blood samples, @entity1 intensity, and physical function were collected at baseline and after 4 weeks of treatment. Results. Subjects in the real APA group reported a 56% reduction of @entity1 intensity and a 26% improvement in physical function. Serum blood samples showed (1) a decrease in @entity4 , @entity3 , @entity2 , and @entity7 [ @entity7 ] and (2) an increase in @entity6 . In contrast, subjects in the sham APA group (1) reported a 9% reduction in @entity1 and a 2% improvement in physical function and (2) exhibited minimal changes of inflammatory cytokines and neuropeptides. Statistically significant differences in @entity6 and @entity7 expression between the real and sham APA groups were verified. Conclusion. These findings suggest that APA treatment affects @entity1 intensity through modulation of the immune system, as reflected by APA-induced changes in serum inflammatory cytokine and neuropeptide levels.

title: The Anti-Inflammatory Actions of Auricular Point Acupressure for XXXX .

answer: @entity5


abstract: UNASSIGNED: microRNAs (miRNAs) are involved in the regulation of almost all physiological and pathological processes, including osteoblast proliferation and differentiation. @entity4 has been reported to be aberrantly expressed in various @entity0 types and to inhibit cell proliferation and invasion by targeting a number of key genes. However, the effects of @entity4 on osteogenic differentiation have not been investigated. Thus, the present study aimed to elucidate the function served by @entity4 in osteogenic differentiation. The expression levels of @entity4 were observed to decrease in a C2C12 cell model of osteogenic differentiation. Overexpression of @entity4 inhibited the activity of key osteoblast markers, including osteocalcin (OC), @entity1 ( @entity1 ) and collagen, type I, a 1 ( @entity3 ). By contrast, inhibition of @entity4 expression resulted in an increase in the osteogenic potential, as indicated by the enhanced expression levels of OC, @entity1 and @entity3 . In addition, a dual-luciferase reporter assay indicated that @entity2 ( @entity2 ) was a target of @entity4 . Western blot analysis revealed that the inhibition of @entity4 led to a significant increase in the protein expression levels of @entity2 . In addition, overexpression of @entity2 was observed to attenuate the @entity4 -mediated suppression of osteogenic differentiation. Therefore, the results demonstrated that @entity4 was able to inhibit osteogenic differentiation via the regulation of @entity2 expression.

title: microRNA-375 inhibits osteogenic differentiation by targeting XXXX .

answer: @entity2


abstract: UNASSIGNED: Sinonasal @entity13 ( @entity13 ) is a soft tissue @entity2 of vascular origin. Open surgical methods and endoscopic techniques are considered the standard treatments for sinonasal @entity13 . However, local recurrences resulting from @entity3 are common. Adjuvant radiotherapy and chemotherapy have also been used to treat @entity13 , however, the number of studies which have investigated effective adjuvant treatments in the literature are limited. The current study reports a 42-year-old male with recurrent and intracranial invasion of sinonasal @entity13 , diagnosed in Xuanwu Hospital (Beijing, China). The @entity0 underwent multiple surgeries to remove the @entity2 , however, no adjuvant therapy was adopted during this period and the @entity2 reoccurred within 1 year. On admittance to Tangshan @entity0 's Hospital (Tangshan, China), the @entity0 presented with @entity9 opening and chewing ability, and @entity4 . Under observation using an electron microscope, @entity13 usually consists of spindle-shaped cells with elongated nuclei and displays characteristic staghorn-like vascular channels. In the present case, immunohistochemical studies were performed on @entity7 -embedded sections of the @entity2 . The @entity2 cells expressed @entity11 , @entity5 (+/-), epithelial membrane antigen, @entity10 , a-actin, @entity12 , @entity14 , S-100, @entity8 and Ki-67 (30%), but were negative for @entity6 kinase. The @entity0 was treated with intensity-modulated radiotherapy and adjuvant chemotherapy, which demonstrated efficacy. No recurrence and @entity1 was observed at the 1 year follow-up subsequent to the combined therapy.

title: Combined therapy against recurrent and intracranial XXXX : A case report.

answer: @entity1


abstract: We measured the intracranial pressure continuously for a period of four days before and after cranioplasty in 12 @entity0 with skull defects larger than 100 cm2. The results were obtained by epidural monitoring. The device used was the "Hellige" pressure measuring device (modified according to Gobiet). We found an increased cranial pressure in more than half of the @entity0 (7). In addition the same @entity0 showed the most marked neurologic and psychic changes. A significant return to normal of the intracranial pressure was noticed in all these @entity0 after the closure of the skull defect. Progressive improvement in the clinical symptoms was also seen. The pathogenesis of this phenomenon has not been completely explained. Several authors consider that an important factor is the difference between the intracranial and the atmospheric pressure, However, we suggest that another important factor is the cicatricial changes ("scar plate") occurring between the cortex, dura and the skin, which exerts pressure on the skull contents. Previously, the neurological symptoms which appeared after a period of time in @entity0 with @entity1 were attributed to other causes. It is only during the past decades--thanks to progress in neuroradiologic diagnostics--that a pathoanatomical correlate been found for these changes.

title: [Intracranial pressure measurement in XXXX ].

answer: @entity1


abstract: BACKGROUND: "Postbariatric" @entity0 are at significant risk for @entity1 . This study aimed to define the risk of @entity6 following body-contouring surgery after massive @entity2 . METHODS: A retrospective analysis was performed on all @entity0 who had undergone all forms of body-contouring procedures after massive @entity2 between January 2005 and August 2012 at St George's Hospital, South West London, United Kingdom. Data were collected on @entity0 demographics, comorbidities, risks factors for @entity4 , preoperative and postoperative body mass index, and type of surgery. RESULTS: A total of 135 operations were performed on 53 @entity0 (43 females, 10 male), with an average age of 44.8 years (range, 26-56 years). Most had staged procedures including 55 abdominoplasties, 23 brachioplasties, 31 thigh lifts, 14 lower-body lifts, and 12 mastopexies. All @entity0 received @entity6 prophylaxis postoperatively including low-molecular-weight heparin ( @entity7 ) within an average of 22.5 hours after surgery and the application of intraoperative graduated compression stockings. @entity0 received @entity7 for an average of 4 days (range, 2-14 days), which correlated to their length of stay. One @entity0 had a @entity5 14 days postoperatively and then 2 days later developed a nonfatal @entity3 , giving a @entity6 prevalence of 0.74% (1/135). CONCLUSIONS: The clinically apparent @entity6 prevalence was low among @entity0 undergoing body-contouring procedures after massive @entity2 in this study. We provide evidence of a successful algorithm to prevent @entity6 for @entity0 undergoing body-contouring procedures after massive @entity2 .

title: Risk of XXXX Following Body-Contouring Surgery After Massive Weight Loss.

answer: @entity4


abstract: 1. The effects of @entity2 (10 mg/kg) on plasma @entity0 , @entity1 , @entity4 and free @entity3 , on adrenal mass and @entity0 content and on body temperature were determined over a 24-h period in 3-week-old Light Sussex chicks. 2. Changes in plasma @entity0 were equivocal, though there was perhaps a trend towards hypercholesteraemia. 3. Birds became hypoglycaemic within an hour but were hyperglycaemic between 2 and 4 h. At 24 h they were normoglycaemic. 4. Plasma @entity4 was increased markedly at 1 h but was decreased compared with the control at 2 h ( P < 0.01). Thereafter the concentration was in the normal range. 5. There was an enhanced hyperlipacidaemia in the treated birds after 1 h. 6. Adrenal @entity0 stores were decreased by 10% at 4 h but were unaffected at all other times. 7. Colonic temperature decreased by 1x6 degrees C after 2 h but was normal by 4 h. 8. It is concluded that @entity2 has mild stressor activity which is lost within 24 h.

title: Short-term stressor effects of XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity7 ( @entity7 ) is an aggressive @entity1 that may present with skeletal and extraskeletal forms. The extraskeletal form is rarely encountered in the head and neck region and is extremely rare in the sinonasal tract. This is the case report of a @entity7 of the ethmoid sinus with intracranial and orbital extension in a 33-year-old male @entity0 who presented with anosmia, @entity5 , @entity4 and @entity2 . On otorhinolaryngological clinical examination and biopsy via flexible endoscope, the lesion was misdiagnosed as ethmoid @entity3 . The subsequent magnetic resonance imaging (MRI) of the brain revealed a large mass (6*7 cm) eroding the ethmoid and sphenoid sinuses, extending beyond the orbits and occupying the anterior cranial fossa with a maximum extension of ~5 cm. The @entity0 underwent surgical resection and the microscopic examination of the specimen established the diagnosis of @entity7 (immunohistochemically positive for @entity10 , @entity9 , @entity8 , @entity11 , pancytokeratin, low-molecular weight cytokeratins and @entity6 . The @entity12 Schiff stain exhibited strong intracytoplasmic block positivity and fluorescence in situ hybridization revealed a t(22;11) translocation. First-line chemotherapy was administered for 3 cycles; however, on restaging MRI, local disease progression was diagnosed. The @entity0 received radiotherapy and second-line chemotherapy for 6 cycles. At 15 months after the diagnosis, the @entity0 remains recurrence-free and maintains a good functional status and quality of life.

title: Primary XXXX of the sinonasal tract, eroding the ethmoid and sphenoid sinus with intracranial extension: A rare case report.

answer: @entity7


abstract: Purpose. To present a case of @entity1 surgery performed in a @entity0 with a refractive corneal inlay in place. Methods. A 48-year-old female @entity0 presented to our institute with bilateral @entity1 . The @entity0 had undergone refractive corneal inlay implantation three years ago in her right, nondominant eye for @entity2 correction. Biometry and intraocular lens (IOL) power calculation were performed without removing the inlay. Phacoemulsification and IOL insertion were carried out in both eyes in a usual manner. Results. On day one postoperatively, the @entity0 achieved binocular uncorrected distance visual acuity 20/20 and uncorrected near visual acuity J1. The vision remained stable during the one-year follow-up period. Conclusion. @entity1 surgery was performed in a standard manner in a @entity0 with Presbia Microlens corneal inlay in place. Visual outcomes for both near and distance vision were satisfactory.

title: XXXX Surgery with a Refractive Corneal Inlay in Place.

answer: @entity1


abstract: A 49-year-old male presented to the emergency with @entity3 and @entity2 in the shaft of the penis for one day. The @entity0 was found to be in a state of shock. The shaft of the penis and the scrotum were swollen and tender. No @entity1 was observed and no crepitus was palpable. Serum white count (WBC) was 29.5 * 10(3)/ L. A CT scan showed gas in the corpus spongiosum. Antibiotics were started with IV @entity4 , @entity6 , and @entity7 / @entity11 . @entity4 was then replaced by @entity8 . Exploration was performed but no @entity1 tissue was identified. Cystourethroscopy revealed dusky looking urethra. A suprapubic tube and a urethral catheter were placed in the bladder. WBC trended down to 13.9 * 10(3)/ L on the fourth postoperative day. Urine culture grew @entity10 and blood cultures grew Alpha Hemolytic Streptococcus. On the sixth day, the @entity0 was feeling worse and WBC increased. MRI revealed absent blood flow to the corpus spongiosum. Urethroscopy revealed @entity1 of the urethra. Urethrectomy was performed via perineal approach. The @entity0 immediately improved. The @entity0 was discharged on the sixth postoperative day to continue @entity5 / @entity9 IV every 6 hours for a total of 4 weeks from the day of urethrectomy.

title: XXXX due to @entity10 .

answer: @entity1


abstract: A 49-year-old male presented to the emergency with @entity3 and @entity2 in the shaft of the penis for one day. The @entity0 was found to be in a state of shock. The shaft of the penis and the scrotum were swollen and tender. No @entity1 was observed and no crepitus was palpable. Serum white count (WBC) was 29.5 * 10(3)/ L. A CT scan showed gas in the corpus spongiosum. Antibiotics were started with IV @entity4 , @entity6 , and @entity7 / @entity11 . @entity4 was then replaced by @entity8 . Exploration was performed but no @entity1 tissue was identified. Cystourethroscopy revealed dusky looking urethra. A suprapubic tube and a urethral catheter were placed in the bladder. WBC trended down to 13.9 * 10(3)/ L on the fourth postoperative day. Urine culture grew @entity10 and blood cultures grew Alpha Hemolytic Streptococcus. On the sixth day, the @entity0 was feeling worse and WBC increased. MRI revealed absent blood flow to the corpus spongiosum. Urethroscopy revealed @entity1 of the urethra. Urethrectomy was performed via perineal approach. The @entity0 immediately improved. The @entity0 was discharged on the sixth postoperative day to continue @entity5 / @entity9 IV every 6 hours for a total of 4 weeks from the day of urethrectomy.

title: @entity1 due to XXXX .

answer: @entity10


abstract: PURPOSE: The present study aimed to improve the design of an interface that may help disabled @entity0 to play a musical instrument. The main point is to integrate @entity0 motion capture in the design process. METHOD: The @entity0 performed 20 pointing movements toward four selected locations. A three one-way analysis of variance (ANOVA) was performed in order to determine the most efficient input location. For each button position, we compared (1) the @entity1 ( @entity1 ), (2) the movement time (MT), and (3) the spatial variability of the movements. RESULTS: According to the results obtained for @entity1 and MT, one position was the most efficient button location in order to produce efficient movements. CONCLUSIONS: As the case study showed, combining the 3D motion capture system and the statistical analysis led to help the designers their design methodology and crucial choices. Implications for Rehabilitation The paper point out the possibility for designers to use motion capture science to improve the efficiency of the personal interface manipulation to play musical instrument. This experiment with the disabled user allows researcher not only to propose standard procedure to characterize an interface but also to take into account the complete behaviour of the user: from the decision of the movement to the execution of the action. The discussion and the experiment with the disabled user help him to better understand its own difficulties. This kind of experimental procedure helps a lot the user in his future rehabilitation choices and decisions.

title: Designing for physically disabled users: benefits from XXXX motion capture - a case study.

answer: @entity0


abstract: OBJECTIVE: To determine the maternal serum N-Terminal proBNP levels in predicting development of @entity6 . METHOD: Sixty-eight @entity0 were included in the study. The study group consisted of @entity0 with the finding of diastolic notch with abnormal pulsatility index (PI) between 21-24  weeks gestation and the control group consisted of @entity0 without diastolic notch and normal PI. The study included high-risk @entity0 who did not have a history of @entity2 before pregnancy, @entity4 , recurrent @entity3 , @entity5 or @entity1 . The groups were compared in terms of NT-ProBNP levels, development of @entity6 , @entity7 . RESULTS: There was no significant difference between groups in terms of age, gravidity, parity, uric acid levels, and NT-proBNP levels. There was significant difference between the groups in terms of week of birth, rate of cesarean section and fetal weight. Furthermore, there were significant differences between the two groups when compared in terms of @entity7 (p  <  0.05). @entity7 were more common in the notch with abnormal (PI) group. The NT-pro @entity8 levels were found to be comparable among groups. Preeclampsia was the most common obstetric problem (11.7  %). We were unable to document significant difference in @entity0 who developed @entity6 . CONCLUSION: Bilateral notch together with abnormal PI measurements in the uterine artery Doppler screening during the second trimester was associated with poor perinatal outcomes. Such an association was not significant in the NT-proBNP measurements. Larger trials focused on late-onset @entity6 are needed to draw definitive conclusions.

title: The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict XXXX .

answer: @entity6


abstract: UNASSIGNED: The aim of this study was to compare physiological responses in @entity6 ( @entity6 ) induced by @entity2 and @entity3 anaesthesia. Two procedures were applied during the experiment. In procedure I, blood samples were collected immediately after exposure (1, 2, 5, 10 min) to the anaesthetic. In procedure II, fish were exposed to the anaesthetic for 10 minutes and then were moved to anaesthetic free water. Blood was sampled after 5, 10, 20 or 30 min of recovery time. Gasometrical and biochemical analyses were performed on collected blood. In @entity3 anaesthetized fish strong @entity1 was revealed. The drop of the HCO3-/ @entity3 ratio, from 28:1 in control fish up to 4:1 in @entity3 anaesthetized ones, proved that the compensation mechanism is not capable of preventing @entity1 during @entity3 anaesthesia in @entity6 . In contrast, only moderate, @entity5 occurred in sturgeons anaesthetised with @entity2 . @entity1 during @entity3 anaesthesia was followed by a fourfold increase of @entity4 level in the blood. @entity0 level, increasing only during recovery time, indicates that a secondary stress response occurred when awareness of anaesthetized fish had been restored.

title: Effects of @entity2 and carbon dioxide on acid-base balance in XXXX .

answer: @entity6


abstract: UNASSIGNED: The aim of this study was to compare physiological responses in @entity6 ( @entity6 ) induced by @entity2 and @entity3 anaesthesia. Two procedures were applied during the experiment. In procedure I, blood samples were collected immediately after exposure (1, 2, 5, 10 min) to the anaesthetic. In procedure II, fish were exposed to the anaesthetic for 10 minutes and then were moved to anaesthetic free water. Blood was sampled after 5, 10, 20 or 30 min of recovery time. Gasometrical and biochemical analyses were performed on collected blood. In @entity3 anaesthetized fish strong @entity1 was revealed. The drop of the HCO3-/ @entity3 ratio, from 28:1 in control fish up to 4:1 in @entity3 anaesthetized ones, proved that the compensation mechanism is not capable of preventing @entity1 during @entity3 anaesthesia in @entity6 . In contrast, only moderate, @entity5 occurred in sturgeons anaesthetised with @entity2 . @entity1 during @entity3 anaesthesia was followed by a fourfold increase of @entity4 level in the blood. @entity0 level, increasing only during recovery time, indicates that a secondary stress response occurred when awareness of anaesthetized fish had been restored.

title: Effects of XXXX and carbon dioxide on acid-base balance in @entity6 .

answer: @entity2


abstract: BACKGROUND: Humeral head cysts are not uncommon in individuals with rotator cuff disorders. The cysts are usually considered an indicator of rotator cuff pathologies; however, they may have different meanings in different regions. PURPOSE: To determine the frequency of cysts within and adjacent to the lesser tuberosity and the relationship between these cysts and subscapularis, supraspinatus, and long @entity2 . MATERIAL AND METHODS: We retrospectively reviewed 760 consecutive shoulder magnetic resonance imaging (MRI) examinations. Among these MRIs, we selected a group of @entity0 with cysts located around the lesser tuberosity. The study population was also divided into two subgroups, @entity0 with @entity3 and those with cysts adjacent to the lesser tuberosity. In addition to the number and size of cysts, the MRI appearance of the tendons was evaluated. RESULTS: Eighty-one (10.7%) @entity0 had cysts within and/or adjacent to the lesser tuberosity, 34 (42%) @entity0 had @entity3 , and 47 (58%) @entity0 had cysts adjacent to it. @entity2 and @entity1 were significantly related to more than one cyst. In a univariate analysis, @entity3 were significantly associated with @entity2 and @entity1 ; however, multivariate analyses showed that only @entity2 were significantly associated with @entity3 . CONCLUSION: Cysts within the lesser tuberosity were less common than cysts adjacent to it. @entity2 and @entity1 were more frequently found in @entity0 with more than one cyst within and/or adjacent to the lesser tuberosity. In addition, @entity3 were associated with @entity2 .

title: Locations of lesser tuberosity cysts and their association with subscapularis, supraspinatus, and XXXX disorders.

answer: @entity2


abstract: Preeclampsia is a frequent medical complication during pregnancy. @entity5 , a @entity2 protease which activates pro-atrial natriuretic peptide, has recently been shown to be involved in the pathophysiology of @entity3 . The aim of this study was to search for @entity5 gene variations and their association to @entity3 in Caucasian and African @entity0 . Our study population was composed of 571 pregnant @entity0 (295 with @entity3 and 276 normotensive controls) matched for maternal and gestational age, and ethnic origin. The 22 exons of the @entity5 gene were sequenced in a discovery sample (n=260), where 31 single @entity1 polymorphisms were identified. In a replication sample (n=311), 4 single @entity1 polymorphisms were tested. Two minor alleles (C for @entity6 and G for @entity7 ) were significantly associated to @entity3 . Adjusted odds ratios [95% confidence interval] were 2.5 [1.2-3.8] (p=0.007) and 2.3 [1.5-3.5] (p=1.3*10-4), respectively. These associations were ethnic-specific, as only found in the Caucasian of subjects (odds ratio=3.5 [1.8-6.6], p=1.1*10-4; odds ratio=3.1 [1.7-5.8], p=2.1*10-4, for each single @entity1 polymorphism, respectively). The two single @entity1 polymorphisms are in almost perfect linkage disequilibrium (r2=0.93). No specific association was found with severe @entity3 , early-onset @entity3 nor @entity4 . In conclusion, this is the first report of a highly significant association between these two single @entity1 polymorphisms in @entity5 gene and @entity3 . Our findings further support the probability of a critical role of @entity5 in preeclamspia pathophysiology at the uteroplacental interface.

title: Highly Significant Association between Two Common Single XXXX Polymorphisms in @entity5 Gene and Preeclampsia in Caucasian @entity0 .

answer: @entity1


abstract: Preeclampsia is a frequent medical complication during pregnancy. @entity5 , a @entity2 protease which activates pro-atrial natriuretic peptide, has recently been shown to be involved in the pathophysiology of @entity3 . The aim of this study was to search for @entity5 gene variations and their association to @entity3 in Caucasian and African @entity0 . Our study population was composed of 571 pregnant @entity0 (295 with @entity3 and 276 normotensive controls) matched for maternal and gestational age, and ethnic origin. The 22 exons of the @entity5 gene were sequenced in a discovery sample (n=260), where 31 single @entity1 polymorphisms were identified. In a replication sample (n=311), 4 single @entity1 polymorphisms were tested. Two minor alleles (C for @entity6 and G for @entity7 ) were significantly associated to @entity3 . Adjusted odds ratios [95% confidence interval] were 2.5 [1.2-3.8] (p=0.007) and 2.3 [1.5-3.5] (p=1.3*10-4), respectively. These associations were ethnic-specific, as only found in the Caucasian of subjects (odds ratio=3.5 [1.8-6.6], p=1.1*10-4; odds ratio=3.1 [1.7-5.8], p=2.1*10-4, for each single @entity1 polymorphism, respectively). The two single @entity1 polymorphisms are in almost perfect linkage disequilibrium (r2=0.93). No specific association was found with severe @entity3 , early-onset @entity3 nor @entity4 . In conclusion, this is the first report of a highly significant association between these two single @entity1 polymorphisms in @entity5 gene and @entity3 . Our findings further support the probability of a critical role of @entity5 in preeclamspia pathophysiology at the uteroplacental interface.

title: Highly Significant Association between Two Common Single @entity1 Polymorphisms in XXXX Gene and Preeclampsia in Caucasian @entity0 .

answer: @entity5


abstract: Preeclampsia is a frequent medical complication during pregnancy. @entity5 , a @entity2 protease which activates pro-atrial natriuretic peptide, has recently been shown to be involved in the pathophysiology of @entity3 . The aim of this study was to search for @entity5 gene variations and their association to @entity3 in Caucasian and African @entity0 . Our study population was composed of 571 pregnant @entity0 (295 with @entity3 and 276 normotensive controls) matched for maternal and gestational age, and ethnic origin. The 22 exons of the @entity5 gene were sequenced in a discovery sample (n=260), where 31 single @entity1 polymorphisms were identified. In a replication sample (n=311), 4 single @entity1 polymorphisms were tested. Two minor alleles (C for @entity6 and G for @entity7 ) were significantly associated to @entity3 . Adjusted odds ratios [95% confidence interval] were 2.5 [1.2-3.8] (p=0.007) and 2.3 [1.5-3.5] (p=1.3*10-4), respectively. These associations were ethnic-specific, as only found in the Caucasian of subjects (odds ratio=3.5 [1.8-6.6], p=1.1*10-4; odds ratio=3.1 [1.7-5.8], p=2.1*10-4, for each single @entity1 polymorphism, respectively). The two single @entity1 polymorphisms are in almost perfect linkage disequilibrium (r2=0.93). No specific association was found with severe @entity3 , early-onset @entity3 nor @entity4 . In conclusion, this is the first report of a highly significant association between these two single @entity1 polymorphisms in @entity5 gene and @entity3 . Our findings further support the probability of a critical role of @entity5 in preeclamspia pathophysiology at the uteroplacental interface.

title: Highly Significant Association between Two Common Single @entity1 Polymorphisms in @entity5 Gene and Preeclampsia in Caucasian XXXX .

answer: @entity0


abstract: We investigated 109 @entity0 exposed and sensitized against organic antigens. 46 of them (group I) are affected with the typical clinical and roentgenological signs of @entity1 . The other 59 subjects (group II) were sensitized only. Included in all examinations were immunological diagnosis by means of counterimmunoelectrophoresis, systematic interviewing for case histories, and registration of respiratory symptoms. Pulmonary function was recorded by means of the following techniques: analysis of ventilation (flow-volume indices), respiratory mechanics of the larger airways and lung (body plethysmography, esophageal balloon technique), respiratory mechanics of the small airways (closing volume, amplitude of @entity3 ), distributional analysis, diffusion analysis, blood gas analysis, and right heart catheterization. @entity4 caused changes in lung mechanics, in airways as well as in lung tissue. The most impressive findings in @entity1 are mechanical inequalities of ventilation. These inequalities may be caused by changed mechanics of overall airways indicated by obstruction parameters and by changed structure of lung tissue reflected in decreased compliance, transfer factors and @entity2 . Not only a restrictive but also an obstructive disturbance of ventilation is found. Impairments are less in sensitized @entity0 . We find slight mechanical and ventilatory inhomogeneities. An overall airway obstruction is obvious but not to such a large extent as in @entity1 . On the contrary, here the lung tissue is not affected. Compliance and diffusion are within the normal range. There is no typical functional pattern specific for the diagnosis of @entity1 .

title: Site and type of impaired lung function in XXXX .

answer: @entity4


abstract: OBJECTIVE: Primary @entity1 (PTL) is an uncommon @entity3 . Despite the rarity of PTL, it is important to recognize PTL promptly because its management differs from that of all the other @entity0 . This study was designed to investigate the sonographic features of PTL. METHODS: Twenty-seven pathologically confirmed PTLs were categorized into diffuse and non-diffuse type. Sonographic features including thyroid size, thyroid background echotexture, lesion size, echogenecity, @entity2 , vascularity, cervical @entity5 of each type were retrospectively analyzed. RESULTS: All 27 PTLs were diffuse large @entity4 and were accompanied by @entity3 . Ten were diffuse type and seventeen were non-diffuse type sonographically. The observations in diffuse group included @entity6 (10/10, 100.0%), marked echogenesity (10/10, 100.0%), heterogeneous echotexture (10/10, 100.0%), and cervical @entity5 (4/10, 40.0%). The observations in non-diffuse group included marked hypoechogenicity (17/17, 100.0%), heterogeneous background thyroid gland (17/17, 100.0%), @entity6 (15/17, 88.2%), increased vascularity (8/13, 61.5%), mulifocality (10/17, 58.8%), and cervical @entity5 (7/17, 41.2%). CONCLUSIONS: Although some common features were found, the sonographic appearance of PTL is unspecific, especially for the diffuse type. Therefore, interventional diagnostic procedures should be warranted in the clinical settings when PTL is suspected.

title: Sonographic appearance of primary XXXX -preliminary experience.

answer: @entity1


abstract: UNASSIGNED: Purpose To assess the natural history of intrameniscal signal intensity on magnetic resonance (MR) images of the medial compartment. Materials and Methods Both knees of 269 @entity0 (55% @entity0 , aged 45-55 years) in the @entity1 Initiative without @entity2 ( @entity1 ) and without medial meniscal tear at baseline were studied. One radiologist assessed 3-T MR images from baseline and 24-, 48-, and 72-month follow-up for intrameniscal signal intensity and tears. A complementary log-log model with random effect was used to evaluate the risk of medial meniscal tear, adjusting for age, sex, body mass index, and knee side. Results At baseline, linear intrameniscal signal intensity in the medial compartment was present in 140 knees (26%). Once present, regression only in a single knee was observed. In 31 knees (19%) with linear intrameniscal signal intensity at any of the first three time points, the signal intensity progressed to a tear in the same segment, and in a single knee, the tear occurred in an adjacent segment. The corresponding number of tears without prior finding of intrameniscal signal intensities was 11 (3%). In the adjusted model, the hazard ratio for developing medial meniscal tear was 18.2 (95% confidence interval: 8.3, 39.8) if linear intrameniscal signal intensity was present, compared when there was no linear signal intensity. There was only one of 43 knees with injury reported in conjunction with the incident tear. Conclusion In middle-aged @entity0 without @entity1 , linear intrameniscal signal intensity on MR images is highly unlikely to resolve and should be considered a risk factor for medial degenerative meniscal tear. (  ) RSNA, 2015 Online supplemental material is available for this article.

title: Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the XXXX Initiative.

answer: @entity1


abstract: HISTORY AND ADMISSION FINDINGS: We report on a 44-year-old @entity0 who was treated for @entity8 in the Department of Psychiatry. In addition, symptoms of @entity4 ( @entity1 , @entity2 , hyperdefecation) were noticeable. @entity10 ( @entity10 ) was marginally elevated, free @entity6 (T3) and free @entity7 (T4) were clearly elevated. Hence, the @entity0 was transferred to the Department of Endocrinology. INVESTIGATIONS: Thyroid ultrasound revealed a @entity9 with a total volume of 24,8 ml. Antibody screening did not show elevated titers. The @entity11 (TRH) test depicted a blunted @entity10 response. Serum levels of free glycoprotein hormone alpha-subunit, prolactin and insulin-like growth factor 1 were increased. DIAGNOSIS, TREATMENT AND COURSE: In cranial magnetic resonance imaging (MRI), a hypointense lesion on the left side of the anterior pituitary gland was detected indicating a thyrotropin-secreting microadenoma with concomitant secretion of prolactin and possible secretion of @entity0 growth hormone (HGH). A thyreostatic therapy was initiated aiming at euthyreosis. For symptom control, betablockers were administered. Subsequently, the @entity0 underwent an uncomplicated transsphenoidal resection. Histological examination confirmed the diagnosis of a @entity3 with expression of @entity10 , prolactin and HGH. As expected, thyroid hormones declined afterwards. CONCLUSIONS: TSHoma is rare. Diagnosis is confirmed by endocrinological testing and cranial imaging. Therapeutic options comprise transsphenoidal adenomectomy, drug therapy ( @entity5 analogues, dopaminergic agonists) and irradiation. Resistance to thyroid hormones should be included in the differential diagnosis.

title: [Endocrine abnormalities in a @entity0 with XXXX - case 8/2014].

answer: @entity8


abstract: HISTORY AND ADMISSION FINDINGS: We report on a 44-year-old @entity0 who was treated for @entity8 in the Department of Psychiatry. In addition, symptoms of @entity4 ( @entity1 , @entity2 , hyperdefecation) were noticeable. @entity10 ( @entity10 ) was marginally elevated, free @entity6 (T3) and free @entity7 (T4) were clearly elevated. Hence, the @entity0 was transferred to the Department of Endocrinology. INVESTIGATIONS: Thyroid ultrasound revealed a @entity9 with a total volume of 24,8 ml. Antibody screening did not show elevated titers. The @entity11 (TRH) test depicted a blunted @entity10 response. Serum levels of free glycoprotein hormone alpha-subunit, prolactin and insulin-like growth factor 1 were increased. DIAGNOSIS, TREATMENT AND COURSE: In cranial magnetic resonance imaging (MRI), a hypointense lesion on the left side of the anterior pituitary gland was detected indicating a thyrotropin-secreting microadenoma with concomitant secretion of prolactin and possible secretion of @entity0 growth hormone (HGH). A thyreostatic therapy was initiated aiming at euthyreosis. For symptom control, betablockers were administered. Subsequently, the @entity0 underwent an uncomplicated transsphenoidal resection. Histological examination confirmed the diagnosis of a @entity3 with expression of @entity10 , prolactin and HGH. As expected, thyroid hormones declined afterwards. CONCLUSIONS: TSHoma is rare. Diagnosis is confirmed by endocrinological testing and cranial imaging. Therapeutic options comprise transsphenoidal adenomectomy, drug therapy ( @entity5 analogues, dopaminergic agonists) and irradiation. Resistance to thyroid hormones should be included in the differential diagnosis.

title: [Endocrine abnormalities in a XXXX with @entity8 - case 8/2014].

answer: @entity0


abstract: There is a lack of studies on Pentravan cream, a widespread transdermal vehicle which is used by compounding pharmacies. The purpose of this study was to evaluate this transdermal vehicle. The permeation performance for @entity2 , @entity1 , and @entity4 in formulations containing each of those drugs separately, as well as an association of @entity1 + @entity4 (Biest), was evaluated regarding their compounding process and their potential biological application. An excised female @entity0 skin model was used to predict the permeation and the retention of the active compounds in every skin layer in lieu of conventional tape stripping. @entity2 was the drug with the highest permeation (37.02 mcg cm(-2) at the end of the experiment). @entity1 and @entity4 in Biest had permeations approximately 4-fold lower (9.44 mcg cm(-2) for @entity1 -Biest and 14.02 mcg cm(-2) for @entity4 -Biest), and the profiles of @entity1 in Eemuls and in Biest were almost the same (9.46 mcg cm(-2) for Eemuls). All permeations followed pseudo- first order kinetics. For @entity2 , using the percentage of permeation by dose, one can infer that a @entity0 using the 1-g emulsion dose released by the pump containing 50 mg of @entity2 will have 38.4 mg of @entity2 liberated into his bloodstream, gradually and continuously for 48 hours. The results indicate that the vehicle was able to provide percutaneous absorption rates compatible with and higher than clinical treatment needs. Using the same rationale, the Eemuls would deliver practically the entire amount of @entity1 load per dose (1.0 mg), approximately 0.5 mg of @entity1 per day. As for the Biest, the dosing used would deliver almost 0.5 mg @entity1 /day and 2.0 mg @entity4 / day. Thus, according to the results, @entity0 female sexual hormones incorporated in the oil-in-water vanishing cream base and applied topically are expected to exert their biological activities systemically with good efficacy due to their satisfactory permeation through @entity0 skin. However, one must take into account that a high quantity of drug was delivered. Thus, to avoid @entity0 @entity3 , care has to be taken regarding the quantity of emulsion used.

title: Evaluation of percutaneous absorption performance for XXXX female sexual steroids into pentravan cream.

answer: @entity0


abstract: The purpose of the present investigation was to study the effects of @entity2 and anabolic @entity1 on serum lipids in power athletes. Altogether 11 national top-level adult athletes completed the study. Five of them volunteered for the study group and the rest for controls. The follow-up consisted of 9 months of a strength training period. During the first 6 months, the subjects in the study group self-administered androgenic @entity1 on an average of 57 +/- 24.9 mg/day. The most interesting observation was the extremely low high-density lipoprotein (HDL) and @entity5 @entity0 concentrations of the @entity3 users. After 8 weeks of training, the study group had significantly (P less than 0.05) lower HDL @entity0 concentrations than the control group (0.53 +/- 0.11 and 1.14 +/- 0.19 mmol/l, respectively). This difference remained significant from 8 to 32 weeks of training. No systematic changes were observed in the control group. The @entity5 @entity0 concentration decreased by about 80% (P less than 0.01) and @entity6 @entity0 by about 55% (P less than 0.01) from the onset values in the study group. A substantial decrease in HDL @entity0 to total @entity0 and in @entity5 @entity0 to @entity6 @entity0 ratios were also noticed under the influence of exogenous @entity4 . The results of this study suggest that the sustained use of @entity2 and anabolic @entity1 have a marked unfavorable effect on the pattern of HDL @entity0 in the serum of male power athletes.

title: Serum lipids in power athletes self-administering XXXX and anabolic @entity1 .

answer: @entity2


abstract: The purpose of the present investigation was to study the effects of @entity2 and anabolic @entity1 on serum lipids in power athletes. Altogether 11 national top-level adult athletes completed the study. Five of them volunteered for the study group and the rest for controls. The follow-up consisted of 9 months of a strength training period. During the first 6 months, the subjects in the study group self-administered androgenic @entity1 on an average of 57 +/- 24.9 mg/day. The most interesting observation was the extremely low high-density lipoprotein (HDL) and @entity5 @entity0 concentrations of the @entity3 users. After 8 weeks of training, the study group had significantly (P less than 0.05) lower HDL @entity0 concentrations than the control group (0.53 +/- 0.11 and 1.14 +/- 0.19 mmol/l, respectively). This difference remained significant from 8 to 32 weeks of training. No systematic changes were observed in the control group. The @entity5 @entity0 concentration decreased by about 80% (P less than 0.01) and @entity6 @entity0 by about 55% (P less than 0.01) from the onset values in the study group. A substantial decrease in HDL @entity0 to total @entity0 and in @entity5 @entity0 to @entity6 @entity0 ratios were also noticed under the influence of exogenous @entity4 . The results of this study suggest that the sustained use of @entity2 and anabolic @entity1 have a marked unfavorable effect on the pattern of HDL @entity0 in the serum of male power athletes.

title: Serum lipids in power athletes self-administering @entity2 and anabolic XXXX .

answer: @entity1