abstract: Five New World camelids were admitted to the Western College of Veterinary Medicine between 1996 and 2003 for evaluation of @entity3 . There were three @entity5 and two @entity4 . Four of the animals were female and three were less than 3 months of age. @entity1 configurations consisted of distal physeal @entity1 (three), a comminuted diaphyseal/metaphyseal @entity1 , and a transverse diaphyseal @entity1 . @entity1 were diagnosed with a combination of physical examination and radiographs in all cases. All five @entity1 were repaired with internal fixation and three animals were discharged from the hospital with @entity1 that healed. One cria underwent successful internal fixation but died from @entity0 during recovery from anaesthesia. @entity2 were rare and limited to inadequate @entity1 stability in one @entity5 and prolonged recovery to weight bearing in another. One @entity4 with a comminuted metaphyseal @entity1 , repaired with a 4.5 mm dynamic compression plate, subsequently had catastrophic failure of the bone 17 days after surgery. Overall the clients were pleased with the outcome of discharged animals. Although @entity3 are considered rare, they pose a unique opportunity for the large animal veterinarian to successfully achieve @entity1 union with the aid of internal fixation.

title: Surgical repair of XXXX in New World camelids: five cases (1996-2003).

answer: @entity3


abstract: OBJECTIVES: To test the hypothesis that increased long-term mortality after hospitalization for @entity4 ( @entity4 ) is independent of comorbid conditions. DESIGN: Prospective observational cohort study in metropolitan areas. SETTING: Memphis, Tennessee, and Pittsburgh, Pennsylvania. @entity0 : Three thousand seventy-five subjects aged 70 to 79 over 5.2 years. MEASUREMENTS: Unadjusted and adjusted mortality from an initial hospitalization for @entity4 were compared with mortality from different causes of hospitalization, including @entity1 , @entity3 , @entity5 ( @entity5 ), @entity2 ( @entity2 ), and other causes. Demographics, smoking, nutritional markers, functional status, inflammatory markers, and chronic health conditions were adjusted for. RESULTS: Of the 106 subjects hospitalized for @entity4 , 22 (20.8%) and 38 (35.8%) died at 1 and 5 years. Subjects hospitalized with @entity4 had higher mortality than nonhospitalized subjects (adjusted odds ratio (OR)=7.8, 95% confidence interval (CI)=4.2-14.4). One- and 5-year mortality after @entity4 hospitalization were higher than mortality from other causes requiring hospitalization and remained unchanged in multivariable analysis (adjusted OR=3.5, 95% CI=1.5-8.1; adjusted OR=5.6, 95% CI=2.8-11.2, respectively). One- and 5-year mortality after hospitalization for @entity4 were similar to or higher than mortality after an initial hospitalization for @entity5 , @entity2 , or @entity3 . Rehospitalization was common in subjects hospitalized for @entity4 and may explain greater long-term mortality. CONCLUSION: In this high-functioning cohort of older @entity0 , an initial hospitalization for @entity4 was associated with greater long-term mortality, independent of prehospitalization comorbid conditions. Hospitalization for @entity4 has as serious a prognosis as hospitalization for @entity5 , @entity2 , or major @entity3 .

title: Influence of comorbid conditions on long-term mortality after pneumonia in older XXXX .

answer: @entity0


abstract: PURPOSE: @entity5 in the @entity6 ( @entity6 ) is a poorly described @entity2 that can be clinically confused with @entity3 . We performed a case-comparison study to document the clinicopathologic characteristics of @entity2 and their association with risk factors for @entity5 . @entity0 AND METHODS: The clinical records and pathology reports from @entity0 who underwent hysterectomy at our institution for @entity5 over an 11-year interval were reviewed. The @entity6 group consisted of @entity0 with @entity5 that clearly originated between the lower uterine corpus and the upper endocervix. Immunohistochemistry and microsatellite instability and @entity9 methylation assays were performed. RESULTS: Thirty-five (3.5%) of 1,009 @entity0 had @entity5 of the @entity6 . Compared with @entity0 with @entity2 , @entity6 @entity0 were younger, had higher stage @entity2 , and had more @entity1 . Preoperative diagnosis of the @entity2 more frequently included the possibility of @entity4 . Seventy-three percent of the @entity2 had an immunohistochemical expression pattern typical of conventional @entity8 . Ten (29%) of 35 @entity0 with @entity2 were confirmed to have @entity7 or were strongly suspected to have @entity7 on the basis of tissue-based molecular assays. CONCLUSION: The prevalence of @entity7 in @entity0 with @entity6 @entity5 (29%) is much greater than that of the general @entity5 @entity0 population (1.8%) or in @entity5 @entity0 younger than age 50 years (8% to 9%). On the basis of our results, the possibility of @entity7 should be considered in @entity0 with @entity2 .

title: XXXX of the @entity6 : a newly described association with @entity7 .

answer: @entity3


abstract: PURPOSE: @entity5 in the @entity6 ( @entity6 ) is a poorly described @entity2 that can be clinically confused with @entity3 . We performed a case-comparison study to document the clinicopathologic characteristics of @entity2 and their association with risk factors for @entity5 . @entity0 AND METHODS: The clinical records and pathology reports from @entity0 who underwent hysterectomy at our institution for @entity5 over an 11-year interval were reviewed. The @entity6 group consisted of @entity0 with @entity5 that clearly originated between the lower uterine corpus and the upper endocervix. Immunohistochemistry and microsatellite instability and @entity9 methylation assays were performed. RESULTS: Thirty-five (3.5%) of 1,009 @entity0 had @entity5 of the @entity6 . Compared with @entity0 with @entity2 , @entity6 @entity0 were younger, had higher stage @entity2 , and had more @entity1 . Preoperative diagnosis of the @entity2 more frequently included the possibility of @entity4 . Seventy-three percent of the @entity2 had an immunohistochemical expression pattern typical of conventional @entity8 . Ten (29%) of 35 @entity0 with @entity2 were confirmed to have @entity7 or were strongly suspected to have @entity7 on the basis of tissue-based molecular assays. CONCLUSION: The prevalence of @entity7 in @entity0 with @entity6 @entity5 (29%) is much greater than that of the general @entity5 @entity0 population (1.8%) or in @entity5 @entity0 younger than age 50 years (8% to 9%). On the basis of our results, the possibility of @entity7 should be considered in @entity0 with @entity2 .

title: @entity3 of the @entity6 : a newly described association with XXXX .

answer: @entity7


abstract: PURPOSE: @entity5 in the @entity6 ( @entity6 ) is a poorly described @entity2 that can be clinically confused with @entity3 . We performed a case-comparison study to document the clinicopathologic characteristics of @entity2 and their association with risk factors for @entity5 . @entity0 AND METHODS: The clinical records and pathology reports from @entity0 who underwent hysterectomy at our institution for @entity5 over an 11-year interval were reviewed. The @entity6 group consisted of @entity0 with @entity5 that clearly originated between the lower uterine corpus and the upper endocervix. Immunohistochemistry and microsatellite instability and @entity9 methylation assays were performed. RESULTS: Thirty-five (3.5%) of 1,009 @entity0 had @entity5 of the @entity6 . Compared with @entity0 with @entity2 , @entity6 @entity0 were younger, had higher stage @entity2 , and had more @entity1 . Preoperative diagnosis of the @entity2 more frequently included the possibility of @entity4 . Seventy-three percent of the @entity2 had an immunohistochemical expression pattern typical of conventional @entity8 . Ten (29%) of 35 @entity0 with @entity2 were confirmed to have @entity7 or were strongly suspected to have @entity7 on the basis of tissue-based molecular assays. CONCLUSION: The prevalence of @entity7 in @entity0 with @entity6 @entity5 (29%) is much greater than that of the general @entity5 @entity0 population (1.8%) or in @entity5 @entity0 younger than age 50 years (8% to 9%). On the basis of our results, the possibility of @entity7 should be considered in @entity0 with @entity2 .

title: @entity3 of the XXXX : a newly described association with @entity7 .

answer: @entity6


abstract: PURPOSE: To evaluate the effectiveness of laser-assisted subepithelial keratectomy (LASEK) to treat residual @entity2 after laser in situ keratomileusis (LASIK). SETTINGS: Isik Eye Clinic, Ankara, @entity1 . METHODS: This retrospective study included 24 eyes of 15 @entity0 who had retreatment by LASEK for residual @entity2 after myopic LASIK. All @entity0 had examinations that included slitlamp biomicroscopy, subjective and cycloplegic refractions, uncorrected visual acuity (UCVA), best corrected visual acuity, corneal topography, and pachymetry preoperatively and postoperatively. Postoperative examinations were performed at 1 week and 1, 3, and 6 months. RESULTS: The @entity0 cohort comprised 9 @entity0 and 6 @entity0 . The median spherical equivalent (SE) of attempted correction for retreatment with LASEK was -1.25 diopters (D). The median follow-up after LASEK was 11.5 months (range 6 to 16 months). At the end of the follow-up, the median SE of the @entity2 was -0.38 D. The median UCVA increased from 20/45 before LASEK to 20/25 at the last follow-up visit, which was statistically significant (P<.001). After LASEK, significant postoperative haze developed in 5 eyes. In all 5 eyes, the estimated ablation depth was more than 40 mum and the SE of attempted correction was -2.00 D or greater. CONCLUSIONS: Laser-assisted subepithelial keratectomy retreatment in eyes with myopic regression after LASIK resulted in a significant improvement in UCVA that was comparable to the improvement after flap lifting. An SE of attempted correction greater than -2.00 D was associated with a significant rate of haze.

title: Effectiveness of laser-assisted subepithelial keratectomy to treat residual XXXX after laser in situ keratomileusis.

answer: @entity2


abstract: Extensive dendritic beading of @entity2 ( @entity2 ) immunoreactivity has previously been observed in the contused @entity0 spinal cord. However, we have also observed dendritic beading in occasional uninjured animals. The purpose of this study was to examine the possibility that perfusion conditions contributed to the dendritic beading. Under deep anesthesia, uninjured @entity0 (adult female Long-Evans, 200-225 g) were transcardially perfused with 0.9% saline solution followed by 4% @entity1 at cold (4 degrees C) or warm (20 degrees C) temperature, and at a low (20 ml/min) or high (50 ml/min) flow rate. Dendrites were visualized by @entity2 immunoreactivity. The results demonstrate that perfusion with cold solutions at a high flow rate induces pronounced dendritic beading, and when perfused at a low flow rate, results in moderate dendritic beading. Warm perfusates did not induce dendritic beading when administered at a low flow rate, but occasional beading was observed with a high flow rate. Western blots revealed spectrin breakdown, but not @entity2 loss, in @entity0 perfused with cold saline solution at a high flow rate, conditions that also resulted in dendritic beading. These findings demonstrate that dendritic morphology is sensitive to both temperature and flow rate of the perfusate. Warm fixative and a low perfusion flow rate minimized the perfusion-induced dendritic beading.

title: Artifactual dendritic beading in @entity0 spinal cord induced by perfusion with cold saline and XXXX .

answer: @entity1


abstract: Extensive dendritic beading of @entity2 ( @entity2 ) immunoreactivity has previously been observed in the contused @entity0 spinal cord. However, we have also observed dendritic beading in occasional uninjured animals. The purpose of this study was to examine the possibility that perfusion conditions contributed to the dendritic beading. Under deep anesthesia, uninjured @entity0 (adult female Long-Evans, 200-225 g) were transcardially perfused with 0.9% saline solution followed by 4% @entity1 at cold (4 degrees C) or warm (20 degrees C) temperature, and at a low (20 ml/min) or high (50 ml/min) flow rate. Dendrites were visualized by @entity2 immunoreactivity. The results demonstrate that perfusion with cold solutions at a high flow rate induces pronounced dendritic beading, and when perfused at a low flow rate, results in moderate dendritic beading. Warm perfusates did not induce dendritic beading when administered at a low flow rate, but occasional beading was observed with a high flow rate. Western blots revealed spectrin breakdown, but not @entity2 loss, in @entity0 perfused with cold saline solution at a high flow rate, conditions that also resulted in dendritic beading. These findings demonstrate that dendritic morphology is sensitive to both temperature and flow rate of the perfusate. Warm fixative and a low perfusion flow rate minimized the perfusion-induced dendritic beading.

title: Artifactual dendritic beading in XXXX spinal cord induced by perfusion with cold saline and @entity1 .

answer: @entity0


abstract: CONTEXT: The role of @entity5 in the risk of @entity2 remains controversial. Recently, a strong association was found between elevated levels of nonfasting @entity5 , which indicate the presence of remnant lipoproteins, and increased risk of @entity4 . OBJECTIVE: To test the hypothesis that increased levels of nonfasting @entity5 are associated with @entity2 in the general population. DESIGN, SETTING, AND @entity0 : The Copenhagen City Heart Study, a prospective, Danish population-based cohort study initiated in 1976, with follow-up through July 2007. @entity0 were 13,956 @entity0 and @entity0 aged 20 through 93 years. A cross-sectional study included 9637 individuals attending the 1991-1994 examination of the prospective study. MAIN OUTCOME MEASURES: Prospective study: baseline levels of nonfasting @entity5 , other risk factors at baseline and at follow-up examinations, and incidence of @entity2 . Cross-sectional study: levels of nonfasting @entity5 , levels of remnant @entity1 , and prevalence of @entity2 . RESULTS: Of the 13,956 @entity0 in the prospective study, 1529 developed @entity2 . Cumulative incidence of @entity2 increased with increasing levels of nonfasting @entity5 (log-rank trend, P < .001). @entity0 with elevated nonfasting @entity3 levels of 89 through 176 mg/dL had multivariate-adjusted hazard ratios (HRs) for @entity2 of 1.3 (95% CI, 0.8-1.9; 351 events); for 177 through 265 mg/dL, 1.6 (95% CI, 1.0-2.5; 189 events); for 266 through 353 mg/dL, 1.5 (95% CI, 0.9-2.7; 73 events); for 354 through 442 mg/dL, 2.2 (95% CI, 1.1-4.2; 40 events); and for 443 mg/dL or greater, 2.5 (95% CI, 1.3-4.8; 41 events) vs @entity0 with nonfasting levels less than 89 mg/dL (HR, 1.0; 85 events) (P < .001 for trend). Corresponding values for @entity0 were 1.3 (95% CI, 0.9-1.7; 407 events), 2.0 (95% CI, 1.3-2.9; 135 events), 1.4 (95% CI, 0.7-2.9; 26 events), 2.5 (95% CI, 1.0-6.4; 13 events), and 3.8 (95% CI, 1.3-11; 10 events) vs @entity0 with nonfasting @entity3 levels less than 89 mg/dL (HR, 1.0; 159 events) (P < .001 for trend). Absolute 10-year risk of @entity2 ranged from 2.6% in @entity0 younger than 55 years with nonfasting @entity3 levels of less than 89 mg/dL to 16.7% in @entity0 aged 55 years or older with levels of 443 mg/dL or greater. Corresponding values in @entity0 were 1.9% and 12.2%. In the cross-sectional study, @entity0 with a previous @entity2 vs controls had nonfasting @entity3 levels of 191 (IQR, 131-259) mg/dL vs 148 (IQR, 104-214) mg/dL (P < .01); corresponding values for @entity0 were 167 (IQR, 121-229) mg/dL vs 127 (IQR, 91-181) mg/dL (P < .05). For remnant @entity1 , corresponding values were 38 (IQR, 26-51) mg/dL vs 29 (IQR, 20-42) mg/dL in @entity0 (P < .01) and 33 (IQR, 24-45) mg/dL vs 25 (IQR, 18-35) mg/dL in @entity0 (P < .05). CONCLUSION: In this study population, nonfasting @entity3 levels were associated with risk of @entity2 .

title: Nonfasting XXXX and risk of @entity2 in the general population.

answer: @entity5


abstract: CONTEXT: The role of @entity5 in the risk of @entity2 remains controversial. Recently, a strong association was found between elevated levels of nonfasting @entity5 , which indicate the presence of remnant lipoproteins, and increased risk of @entity4 . OBJECTIVE: To test the hypothesis that increased levels of nonfasting @entity5 are associated with @entity2 in the general population. DESIGN, SETTING, AND @entity0 : The Copenhagen City Heart Study, a prospective, Danish population-based cohort study initiated in 1976, with follow-up through July 2007. @entity0 were 13,956 @entity0 and @entity0 aged 20 through 93 years. A cross-sectional study included 9637 individuals attending the 1991-1994 examination of the prospective study. MAIN OUTCOME MEASURES: Prospective study: baseline levels of nonfasting @entity5 , other risk factors at baseline and at follow-up examinations, and incidence of @entity2 . Cross-sectional study: levels of nonfasting @entity5 , levels of remnant @entity1 , and prevalence of @entity2 . RESULTS: Of the 13,956 @entity0 in the prospective study, 1529 developed @entity2 . Cumulative incidence of @entity2 increased with increasing levels of nonfasting @entity5 (log-rank trend, P < .001). @entity0 with elevated nonfasting @entity3 levels of 89 through 176 mg/dL had multivariate-adjusted hazard ratios (HRs) for @entity2 of 1.3 (95% CI, 0.8-1.9; 351 events); for 177 through 265 mg/dL, 1.6 (95% CI, 1.0-2.5; 189 events); for 266 through 353 mg/dL, 1.5 (95% CI, 0.9-2.7; 73 events); for 354 through 442 mg/dL, 2.2 (95% CI, 1.1-4.2; 40 events); and for 443 mg/dL or greater, 2.5 (95% CI, 1.3-4.8; 41 events) vs @entity0 with nonfasting levels less than 89 mg/dL (HR, 1.0; 85 events) (P < .001 for trend). Corresponding values for @entity0 were 1.3 (95% CI, 0.9-1.7; 407 events), 2.0 (95% CI, 1.3-2.9; 135 events), 1.4 (95% CI, 0.7-2.9; 26 events), 2.5 (95% CI, 1.0-6.4; 13 events), and 3.8 (95% CI, 1.3-11; 10 events) vs @entity0 with nonfasting @entity3 levels less than 89 mg/dL (HR, 1.0; 159 events) (P < .001 for trend). Absolute 10-year risk of @entity2 ranged from 2.6% in @entity0 younger than 55 years with nonfasting @entity3 levels of less than 89 mg/dL to 16.7% in @entity0 aged 55 years or older with levels of 443 mg/dL or greater. Corresponding values in @entity0 were 1.9% and 12.2%. In the cross-sectional study, @entity0 with a previous @entity2 vs controls had nonfasting @entity3 levels of 191 (IQR, 131-259) mg/dL vs 148 (IQR, 104-214) mg/dL (P < .01); corresponding values for @entity0 were 167 (IQR, 121-229) mg/dL vs 127 (IQR, 91-181) mg/dL (P < .05). For remnant @entity1 , corresponding values were 38 (IQR, 26-51) mg/dL vs 29 (IQR, 20-42) mg/dL in @entity0 (P < .01) and 33 (IQR, 24-45) mg/dL vs 25 (IQR, 18-35) mg/dL in @entity0 (P < .05). CONCLUSION: In this study population, nonfasting @entity3 levels were associated with risk of @entity2 .

title: Nonfasting @entity5 and risk of XXXX in the general population.

answer: @entity2


abstract: The records of 187 consecutive @entity0 (206 eyes) with a diagnosis of secondary premacular @entity1 were reviewed. The mean @entity0 age was 63.2 years; 96 (51.3%) @entity0 were @entity0 . The most common surgical causes in 175 eyes were @entity2 extraction with or without implant, 73 (41.7%); scleral buckle, 33 (18.9%); both @entity2 extraction with implant and scleral buckle (in separate surgical sessions), 20 (11.4%); argon laser procedures, 17 (9.7%); and @entity7 cryopexy, 14 (8.0%). The most common nonsurgical causes in 31 eyes were blunt @entity5 , 12 (38.7%); @entity4 , 9 (29.0%); and @entity6 , 5 (16.1%). Initial visual acuity was 20/100 or better in 120 of the 206 eyes (58.3%). After a minimum follow-up period of 6 months (mean, 44.2 months), 72 of 101 eyes (71.3%) had stable or improved visual acuity without surgical intervention. Of 32 eyes that underwent vitrectomy with membrane stripping, 25 of 26 eyes (96.2%) followed for a mean period of 24 months (minimum, 6 months) had stable or improved visual acuity. Of 157 eyes that did not undergo vitrectomy, 143 (91.1%) had @entity8 . Fifty-eight of 148 eyes (39.2%) had angiographic @entity3 ; however, vitreous traction at the macula was not a significant cause of @entity3 ( @entity3 ) in these eyes.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Secondary causes of premacular XXXX .

answer: @entity1


abstract: OBJECTIVE: To investigate the therapeautic effect of damage control orthopaedics (DCO) applicated to thoracolumbar burst @entity1 complicated with severe @entity5 . METHODS: Twenty-one @entity0 with severe polytrama including 15 males and 6 females with an average age of 40-years-old ranging from 20 to 60 years, were treated by immediate fluid resuscitation and emergency simple operation so as to control the @entity4 and contamination. According to Frankel grade of spinal nerves function, 3 cases were grade A, 3 were grade B, 9 were grade C, 6 were grade D. Ten cases were performed to open abdominal operation, 6 cases underwent closed negative pressure drainage thorough chest, 2 cases with @entity2 were treated by repairing operation. During operation, 9 cases were treated with by external fixation and 5 cases were skeletal traction or external fixation with plaster support for extremities @entity1 . After emergency operation, the @entity0 were transported into surgical intensive care unit (SICU), and corrected the @entity6 , @entity3 and @entity7 . The definitive thoracolumbar operation was performed between 5 to 7 days as soon as the vital signs became stable. RESULTS: Among 21 cases, @entity4 was corrected rapidly in 18 cases and 3 cases died in 4 to 26 hours. The survival rate was about 85.7% (18/21). Eighteen @entity0 were followed up for 6 to 14 months with an average of 10 months. According to Frankel grading, 3 cases were grade A, 2 cases were grade B, 3 cases were grade C, 3 cases were grade D, 7 cases were grade E. CONCLUSION: It may increase the therapy achievement rate excellently and decrease the disabled rate that performing damage control orthopaedics (DCO) timely, relifing the compression on the spinal cord and re-establishing the stability of spinal column as early as possible.

title: [Damage control orthopaedics of thoracolumbar burst @entity1 complicated with severe XXXX ].

answer: @entity5


abstract: OBJECTIVE: To investigate the therapeautic effect of damage control orthopaedics (DCO) applicated to thoracolumbar burst @entity1 complicated with severe @entity5 . METHODS: Twenty-one @entity0 with severe polytrama including 15 males and 6 females with an average age of 40-years-old ranging from 20 to 60 years, were treated by immediate fluid resuscitation and emergency simple operation so as to control the @entity4 and contamination. According to Frankel grade of spinal nerves function, 3 cases were grade A, 3 were grade B, 9 were grade C, 6 were grade D. Ten cases were performed to open abdominal operation, 6 cases underwent closed negative pressure drainage thorough chest, 2 cases with @entity2 were treated by repairing operation. During operation, 9 cases were treated with by external fixation and 5 cases were skeletal traction or external fixation with plaster support for extremities @entity1 . After emergency operation, the @entity0 were transported into surgical intensive care unit (SICU), and corrected the @entity6 , @entity3 and @entity7 . The definitive thoracolumbar operation was performed between 5 to 7 days as soon as the vital signs became stable. RESULTS: Among 21 cases, @entity4 was corrected rapidly in 18 cases and 3 cases died in 4 to 26 hours. The survival rate was about 85.7% (18/21). Eighteen @entity0 were followed up for 6 to 14 months with an average of 10 months. According to Frankel grading, 3 cases were grade A, 2 cases were grade B, 3 cases were grade C, 3 cases were grade D, 7 cases were grade E. CONCLUSION: It may increase the therapy achievement rate excellently and decrease the disabled rate that performing damage control orthopaedics (DCO) timely, relifing the compression on the spinal cord and re-establishing the stability of spinal column as early as possible.

title: [Damage control orthopaedics of thoracolumbar burst XXXX complicated with severe @entity5 ].

answer: @entity1


abstract: Fatigue is prevalent among @entity1 @entity0 , including @entity6 ( @entity6 ). Fatigue is poorly understood, and the clinical management is consequently difficult. This cross-sectional study examined how @entity7 related to @entity2 morbidity among 457 @entity6 (aged 19-74 years, 56% males) treated during the period 1971-1991. The subjects were mailed a questionnaire including the Fatigue Questionnaire, the Hospital Anxiety and @entity4 Scale, and measures of previous @entity2 problems. Fatigue correlated moderately with @entity3 and @entity4 (r = 0.44 and 0.41 respectively). Twenty-six percent of the @entity6 had substantial @entity7 for 6 months or longer (=cases). They had higher levels of @entity3 (mean 7.3, 95% CI 6.4-8.1) and @entity4 (mean 4.5, 95% CI 3.8-5.2) than the non-cases ( @entity3 : mean 4.3, 95% CI 3.9-4.7; @entity4 : mean 2.1, 95% CI 1.8-2.5). Past @entity2 problems were not reported more commonly among the @entity7 cases than among the non-cases. A multiple logistic regression analysis identified age (OR 1.04, 95% CI 1.02-1.06), @entity3 (OR 1.2, 95% CI 1.2-1.3), and no self-reported @entity2 symptoms during treatment (OR 2.3, 95% CI 1.3-4.2) as predictors of @entity7 caseness. One-half of the @entity7 cases among @entity6 have @entity5 that might respond to treatment. Chronic @entity7 among @entity6 is not predicted by previous @entity2 problems.

title: Fatigue and @entity2 morbidity among XXXX .

answer: @entity6


abstract: Fatigue is prevalent among @entity1 @entity0 , including @entity6 ( @entity6 ). Fatigue is poorly understood, and the clinical management is consequently difficult. This cross-sectional study examined how @entity7 related to @entity2 morbidity among 457 @entity6 (aged 19-74 years, 56% males) treated during the period 1971-1991. The subjects were mailed a questionnaire including the Fatigue Questionnaire, the Hospital Anxiety and @entity4 Scale, and measures of previous @entity2 problems. Fatigue correlated moderately with @entity3 and @entity4 (r = 0.44 and 0.41 respectively). Twenty-six percent of the @entity6 had substantial @entity7 for 6 months or longer (=cases). They had higher levels of @entity3 (mean 7.3, 95% CI 6.4-8.1) and @entity4 (mean 4.5, 95% CI 3.8-5.2) than the non-cases ( @entity3 : mean 4.3, 95% CI 3.9-4.7; @entity4 : mean 2.1, 95% CI 1.8-2.5). Past @entity2 problems were not reported more commonly among the @entity7 cases than among the non-cases. A multiple logistic regression analysis identified age (OR 1.04, 95% CI 1.02-1.06), @entity3 (OR 1.2, 95% CI 1.2-1.3), and no self-reported @entity2 symptoms during treatment (OR 2.3, 95% CI 1.3-4.2) as predictors of @entity7 caseness. One-half of the @entity7 cases among @entity6 have @entity5 that might respond to treatment. Chronic @entity7 among @entity6 is not predicted by previous @entity2 problems.

title: Fatigue and XXXX morbidity among @entity6 .

answer: @entity2


abstract: @entity6 is a @entity2 of unknown etiology that is characterized by the formation of noncaseating @entity8 . Gastrointestinal (GI) tract involvement in @entity6 is rare. @entity5 , particularly involving the antrum, affects approximately 10% of @entity0 with @entity2 . @entity3 commonly occurs subclinically, with clinical manifestations present in only 0.1 to 0.9% of @entity0 with the disease. This is a rare case report of an individual with symptomatic @entity5 . The @entity0 presented with @entity4 , @entity7 , and early satiety. An EGD and colonoscopy were performed and were grossly normal. However, biopsies of the gastric antrum revealed noncaseating @entity1 involving the gastric mucosa. Corticosteroid therapy was started and the symptoms abated almost immediately. We also offer a review of the literature.

title: XXXX : a case report and review of the literature.

answer: @entity5


abstract: A. Storey et al. [Nature (Lond.), 393: 229-234, 1998)] reported a 7-fold increased risk of @entity2 associated with having an @entity4 / @entity4 polymorphism at codon 72 of @entity5 compared with the Pro/ @entity4 heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4). Complementary in vitro studies suggested that the HPV E6 oncoprotein more readily targets the @entity3 form, as opposed to the @entity7 form, of @entity5 for degradation. We investigated the impact of this polymorphism in a population-based case-control study of @entity1 . Using a PCR assay to detect the @entity5 codon 72 polymorphism, we tested blood samples from 111 @entity0 with invasive @entity8 of the cervix identified by a population-based registry and 164 random-digit telephone-dialed controls. The distribution of the genotype among control @entity0 was 38% heterozygous, 7% @entity7 homozygous, and 55% @entity3 homozygous, and among the cases was 38%, 6%, and 56%, respectively. There was no increased risk of @entity8 associated with homozygosity for the @entity3 allele (odds ratio, 1.0; 95% confidence interval, 0.6-1.7). Furthermore, there was no modification of this result by @entity6 ) DNA status of the @entity2 , age, or smoking status. Among controls, there was no association between the polymorphism and @entity9 L1 seropositivity. However, among case subjects, the codon 72 polymorphism may be related to @entity9 L1 seropositivity status.

title: The XXXX Arg72Pro polymorphism, @entity6 , and invasive @entity8 .

answer: @entity5


abstract: A. Storey et al. [Nature (Lond.), 393: 229-234, 1998)] reported a 7-fold increased risk of @entity2 associated with having an @entity4 / @entity4 polymorphism at codon 72 of @entity5 compared with the Pro/ @entity4 heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4). Complementary in vitro studies suggested that the HPV E6 oncoprotein more readily targets the @entity3 form, as opposed to the @entity7 form, of @entity5 for degradation. We investigated the impact of this polymorphism in a population-based case-control study of @entity1 . Using a PCR assay to detect the @entity5 codon 72 polymorphism, we tested blood samples from 111 @entity0 with invasive @entity8 of the cervix identified by a population-based registry and 164 random-digit telephone-dialed controls. The distribution of the genotype among control @entity0 was 38% heterozygous, 7% @entity7 homozygous, and 55% @entity3 homozygous, and among the cases was 38%, 6%, and 56%, respectively. There was no increased risk of @entity8 associated with homozygosity for the @entity3 allele (odds ratio, 1.0; 95% confidence interval, 0.6-1.7). Furthermore, there was no modification of this result by @entity6 ) DNA status of the @entity2 , age, or smoking status. Among controls, there was no association between the polymorphism and @entity9 L1 seropositivity. However, among case subjects, the codon 72 polymorphism may be related to @entity9 L1 seropositivity status.

title: The @entity5 Arg72Pro polymorphism, XXXX , and invasive @entity8 .

answer: @entity6


abstract: A. Storey et al. [Nature (Lond.), 393: 229-234, 1998)] reported a 7-fold increased risk of @entity2 associated with having an @entity4 / @entity4 polymorphism at codon 72 of @entity5 compared with the Pro/ @entity4 heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4). Complementary in vitro studies suggested that the HPV E6 oncoprotein more readily targets the @entity3 form, as opposed to the @entity7 form, of @entity5 for degradation. We investigated the impact of this polymorphism in a population-based case-control study of @entity1 . Using a PCR assay to detect the @entity5 codon 72 polymorphism, we tested blood samples from 111 @entity0 with invasive @entity8 of the cervix identified by a population-based registry and 164 random-digit telephone-dialed controls. The distribution of the genotype among control @entity0 was 38% heterozygous, 7% @entity7 homozygous, and 55% @entity3 homozygous, and among the cases was 38%, 6%, and 56%, respectively. There was no increased risk of @entity8 associated with homozygosity for the @entity3 allele (odds ratio, 1.0; 95% confidence interval, 0.6-1.7). Furthermore, there was no modification of this result by @entity6 ) DNA status of the @entity2 , age, or smoking status. Among controls, there was no association between the polymorphism and @entity9 L1 seropositivity. However, among case subjects, the codon 72 polymorphism may be related to @entity9 L1 seropositivity status.

title: The @entity5 Arg72Pro polymorphism, @entity6 , and invasive XXXX .

answer: @entity8


abstract: BACKGROUND: Although there are effective ways of treating @entity1 , only a minority of all @entity1 @entity0 reach target blood pressure levels. This may be a function of how @entity0 and physicians put measured values into context when they decide if the blood pressure is well controlled or too high. METHODOLOGY: Qualitative analysis of audio-taped follow-up appointments for @entity1 between 51 outpatients and their 11 physicians. All @entity0 came for routine follow-up appointments for @entity1 . The setting was primary and a specialist outpatient care in the south of Sweden. PRINCIPAL FINDINGS: Borderline blood pressure values led to more deliberation. Common ways of contextualising the blood pressure were by comparing it to previous values and by explaining it in terms of stress or lack of rest. The net effect of this was that the representativity and severity of the measured blood pressure value were downplayed by both @entity0 and physicians. In some instances, physicians (but not @entity0 ) worked in the opposite direction. @entity0 were less actively engaged in interpreting the blood pressure values, stated their views about therapy less often, and were careful not to express views that were overly critical of the drug treatment. CONCLUSIONS: @entity0 and physicians make sense of the blood pressure through a contextualisation process which tends to normalise the face values towards the reference values. The resulting (processed) value is the one acted upon. Discursive handling of the blood pressure therefore makes up an important part of the decision-making.

title: Making sense of blood pressure values in follow-up appointments for XXXX .

answer: @entity1


abstract: BACKGROUND AND PURPOSE: @entity4 ( @entity4 ) stands out from other subtypes of @entity2 because of the high early mortality and the risk of complications. Serum glial fibrillary acidic protein (s- @entity5 ) concentrations are increased after @entity2 . The aim of this study was to investigate whether s- @entity5 could be used as a marker of @entity3 and outcome after @entity4 . METHODS: Serum samples were obtained on a regular basis from 116 adults during a 2-week period after @entity4 and analyzed using an enzyme-linked immunosorbent assay. The World Federation of Neurological Surgeons scale was used for neurological evaluation. Outcome was assessed after 1 year and categorized according to the Extended Glasgow Outcome Scale. RESULTS: Increased s- @entity5 levels were seen in 81 of the 116 @entity0 . Maximum s- @entity5 correlated with World Federation of Neurological Surgeons scale on arrival and on days 10 to 15 (r=0.37, P<0.001 and r=0.47, P<0.001, respectively). Furthermore, maximum s- @entity5 levels were increased in the @entity0 group with radiological signs of focal lesions acute or at 1 year, compared with the group without focal lesions (P<0.001 in both comparisons). @entity0 with secondary events (re- @entity6 or @entity1 ) reached maximum levels later in the series and both maximum and final s- @entity5 levels increased compared with the levels in @entity0 without secondary events (P<0.001 in all 3 comparisons). Finally, maximum s- @entity5 correlated with outcome (r=-0.48, P<0.001) and s- @entity5 was an independent predictor of dichotomized outcome. CONCLUSIONS: s- @entity5 provides information about @entity7 severity and outcome after @entity4 , which can be useful as a complement to clinical data.

title: Serum glial fibrillary acidic protein is related to focal @entity7 and outcome after XXXX .

answer: @entity4


abstract: BACKGROUND AND PURPOSE: @entity4 ( @entity4 ) stands out from other subtypes of @entity2 because of the high early mortality and the risk of complications. Serum glial fibrillary acidic protein (s- @entity5 ) concentrations are increased after @entity2 . The aim of this study was to investigate whether s- @entity5 could be used as a marker of @entity3 and outcome after @entity4 . METHODS: Serum samples were obtained on a regular basis from 116 adults during a 2-week period after @entity4 and analyzed using an enzyme-linked immunosorbent assay. The World Federation of Neurological Surgeons scale was used for neurological evaluation. Outcome was assessed after 1 year and categorized according to the Extended Glasgow Outcome Scale. RESULTS: Increased s- @entity5 levels were seen in 81 of the 116 @entity0 . Maximum s- @entity5 correlated with World Federation of Neurological Surgeons scale on arrival and on days 10 to 15 (r=0.37, P<0.001 and r=0.47, P<0.001, respectively). Furthermore, maximum s- @entity5 levels were increased in the @entity0 group with radiological signs of focal lesions acute or at 1 year, compared with the group without focal lesions (P<0.001 in both comparisons). @entity0 with secondary events (re- @entity6 or @entity1 ) reached maximum levels later in the series and both maximum and final s- @entity5 levels increased compared with the levels in @entity0 without secondary events (P<0.001 in all 3 comparisons). Finally, maximum s- @entity5 correlated with outcome (r=-0.48, P<0.001) and s- @entity5 was an independent predictor of dichotomized outcome. CONCLUSIONS: s- @entity5 provides information about @entity7 severity and outcome after @entity4 , which can be useful as a complement to clinical data.

title: Serum glial fibrillary acidic protein is related to focal XXXX and outcome after @entity4 .

answer: @entity7


abstract: INTRODUCTION: The objective was to study immune regulation in a @entity0 model of @entity3 that exhibits considerable heterogeneity of disease activity. METHODS: T-cell receptor @entity0 , in which nearly all @entity8 + T cells recognize a single peptide of type II collagen, were immunized with collagen and observed for development of @entity5 for 4 weeks. At 28 days post-immunization, splenocytes were analyzed by flow cytometry and in vitro assays for markers of immune activation and regulation. RESULTS: Disease severities ranging from 0 to 12 (on a 12-point scale) were observed. Among splenic lymphocyte populations, only the @entity9 + B-cell subset displayed a @entity4 as @entity5 severity increased. Splenic @entity9 + B cells expressed higher levels of @entity10 ( @entity10 ) than did @entity8 + T cells or @entity9 - B cells in all mice, and antigen-dependent @entity2 correlated with higher levels of @entity9 + B cells in cocultures. Ratios of @entity6 to @entity1 production were higher in antigen-driven cultures of splenocytes from severely arthritic @entity0 compared to mildly or nonarthritic @entity0 . A correlation was established between the reduced production of @entity6 in antigen-driven T-cell/B-cell cocultures and @entity10 , but not @entity7 . Confirmation of the direct killing effect of B cells on T cells was demonstrated using an antigen-specific T hybridoma cell line. CONCLUSIONS: Reduced numbers of splenic @entity10 + @entity9 + B cells correlated with increasing @entity5 severity and @entity2 in a T-cell receptor transgenic @entity0 model of collagen-induced @entity5 . These 'killer' B cells may provide a novel mechanism for inducing @entity2 as a treatment for @entity5 .

title: Reduced XXXX -expressing splenic @entity9 + B lymphocytes in severe collagen-induced @entity5 .

answer: @entity10


abstract: INTRODUCTION: The objective was to study immune regulation in a @entity0 model of @entity3 that exhibits considerable heterogeneity of disease activity. METHODS: T-cell receptor @entity0 , in which nearly all @entity8 + T cells recognize a single peptide of type II collagen, were immunized with collagen and observed for development of @entity5 for 4 weeks. At 28 days post-immunization, splenocytes were analyzed by flow cytometry and in vitro assays for markers of immune activation and regulation. RESULTS: Disease severities ranging from 0 to 12 (on a 12-point scale) were observed. Among splenic lymphocyte populations, only the @entity9 + B-cell subset displayed a @entity4 as @entity5 severity increased. Splenic @entity9 + B cells expressed higher levels of @entity10 ( @entity10 ) than did @entity8 + T cells or @entity9 - B cells in all mice, and antigen-dependent @entity2 correlated with higher levels of @entity9 + B cells in cocultures. Ratios of @entity6 to @entity1 production were higher in antigen-driven cultures of splenocytes from severely arthritic @entity0 compared to mildly or nonarthritic @entity0 . A correlation was established between the reduced production of @entity6 in antigen-driven T-cell/B-cell cocultures and @entity10 , but not @entity7 . Confirmation of the direct killing effect of B cells on T cells was demonstrated using an antigen-specific T hybridoma cell line. CONCLUSIONS: Reduced numbers of splenic @entity10 + @entity9 + B cells correlated with increasing @entity5 severity and @entity2 in a T-cell receptor transgenic @entity0 model of collagen-induced @entity5 . These 'killer' B cells may provide a novel mechanism for inducing @entity2 as a treatment for @entity5 .

title: Reduced @entity10 -expressing splenic XXXX + B lymphocytes in severe collagen-induced @entity5 .

answer: @entity9


abstract: INTRODUCTION: The objective was to study immune regulation in a @entity0 model of @entity3 that exhibits considerable heterogeneity of disease activity. METHODS: T-cell receptor @entity0 , in which nearly all @entity8 + T cells recognize a single peptide of type II collagen, were immunized with collagen and observed for development of @entity5 for 4 weeks. At 28 days post-immunization, splenocytes were analyzed by flow cytometry and in vitro assays for markers of immune activation and regulation. RESULTS: Disease severities ranging from 0 to 12 (on a 12-point scale) were observed. Among splenic lymphocyte populations, only the @entity9 + B-cell subset displayed a @entity4 as @entity5 severity increased. Splenic @entity9 + B cells expressed higher levels of @entity10 ( @entity10 ) than did @entity8 + T cells or @entity9 - B cells in all mice, and antigen-dependent @entity2 correlated with higher levels of @entity9 + B cells in cocultures. Ratios of @entity6 to @entity1 production were higher in antigen-driven cultures of splenocytes from severely arthritic @entity0 compared to mildly or nonarthritic @entity0 . A correlation was established between the reduced production of @entity6 in antigen-driven T-cell/B-cell cocultures and @entity10 , but not @entity7 . Confirmation of the direct killing effect of B cells on T cells was demonstrated using an antigen-specific T hybridoma cell line. CONCLUSIONS: Reduced numbers of splenic @entity10 + @entity9 + B cells correlated with increasing @entity5 severity and @entity2 in a T-cell receptor transgenic @entity0 model of collagen-induced @entity5 . These 'killer' B cells may provide a novel mechanism for inducing @entity2 as a treatment for @entity5 .

title: Reduced @entity10 -expressing splenic @entity9 + B lymphocytes in severe collagen-induced XXXX .

answer: @entity5


abstract: @entity2 is an experimental antibacterial and antiendotoxic compound whose clinical utility as an antitumor agent is being investigated in @entity0 clinical trials. @entity2 in aqueous solution exists in equilibrium with @entity3 . @entity3 is subsequently transformed to @entity4 . The pharmacokinetic profiles of these metabolites are not well established. In this study, 18 healthy volunteers were administered 5.0 g of @entity2 in 250 mL of 5% @entity1 in water over 2, 1, or 0.5 hours by intravenous infusion in a parallel-group design. All subjects noted discomfort at the infusion site, although there were no serious adverse events. t(max) generally occurred at the end of infusion for @entity4 , whereas that of @entity3 was reached before completion of infusion. The @entity2 metabolite @entity3 demonstrated a shorter half-life and lower systemic exposure than @entity4 . Shortening of infusion duration increased the C(max) and AUC of @entity3 . Changes in infusion rate did not substantially change the pharmacokinetic parameters of @entity4 .

title: The pharmacokinetics of XXXX metabolites in healthy volunteers.

answer: @entity2


abstract: Of the 120 @entity7 ( @entity7 ) @entity0 treated by the authors, two have developed @entity6 . The authors' objective is to present this rare, but severe manifestation. @entity0 1 and 2 were 66- and 22-year old @entity0 , respectively. Both had @entity7 with multi-organ involvements including diffuse proliferative @entity9 . Before the diagnosis of the disease, both @entity0 had experienced @entity2 that resolved on corticosteroid treatment. Soon after the diagnosis, @entity8 , haemoptoea and acute @entity5 developed, accompanied by a rapid deterioration in the general condition. Chest radiographs revealed bilateral, diffuse, alveolar infiltrates. The @entity6 temporarily ceased in response to @entity3 treatment, but both @entity0 later died in consequence of active @entity7 and mixed @entity4 . Post mortem examination demonstrated @entity10 and @entity6 in @entity0 1, and an immune complex deposition-induced @entity1 with @entity6 in @entity0 2. @entity6 is a life-threatening manifestation of @entity7 . Its onset may be preceded by episodes of @entity2 resolving on corticosteroid treatment. An active diagnostic workup, intensive observation and aggressive immunosuppressive treatment are the cornerstones of the management. The early detection and the active treatment of secondary infections are obligatory. The authors consider the most difficult challenge to be the optimum coordination of the above treatment modalities.

title: [Diffuse @entity6 in XXXX ].

answer: @entity7


abstract: Of the 120 @entity7 ( @entity7 ) @entity0 treated by the authors, two have developed @entity6 . The authors' objective is to present this rare, but severe manifestation. @entity0 1 and 2 were 66- and 22-year old @entity0 , respectively. Both had @entity7 with multi-organ involvements including diffuse proliferative @entity9 . Before the diagnosis of the disease, both @entity0 had experienced @entity2 that resolved on corticosteroid treatment. Soon after the diagnosis, @entity8 , haemoptoea and acute @entity5 developed, accompanied by a rapid deterioration in the general condition. Chest radiographs revealed bilateral, diffuse, alveolar infiltrates. The @entity6 temporarily ceased in response to @entity3 treatment, but both @entity0 later died in consequence of active @entity7 and mixed @entity4 . Post mortem examination demonstrated @entity10 and @entity6 in @entity0 1, and an immune complex deposition-induced @entity1 with @entity6 in @entity0 2. @entity6 is a life-threatening manifestation of @entity7 . Its onset may be preceded by episodes of @entity2 resolving on corticosteroid treatment. An active diagnostic workup, intensive observation and aggressive immunosuppressive treatment are the cornerstones of the management. The early detection and the active treatment of secondary infections are obligatory. The authors consider the most difficult challenge to be the optimum coordination of the above treatment modalities.

title: [Diffuse XXXX in @entity7 ].

answer: @entity6


abstract: OBJECTIVE: Despite evidence demonstrating that risk-factor management is effective in reducing recurrent @entity2 , there are very few structured care programmes for @entity1 survivors. The aim was to implement and evaluate an integrated care programme in @entity1 . METHODS: 186 @entity0 with @entity1 were randomised to either the treatment (integrated care) or control (usual care) group and were followed up over 12 months. The Integrated Care for the Reduction of @entity1 (ICARUSS) model of integrated care involved collaboration between a specialist @entity1 service, a hospital coordinator and a @entity0 's general practitioner. The primary aim was to promote the management of vascular risk factors through ongoing @entity0 contact and education. RESULTS: In the 12 months poststroke, systolic blood pressure (sBP) decreased in the treatment group but increased in controls. The group difference was significant, and remained so when age, sex, disability and sBP at discharge were accounted for (p = 0.04). Treatment @entity0 also exhibited better modification of body mass index (p = 0.007) and number of walks taken (p<0.001) than controls. Rankin scores indicated significantly @entity3 in treatment @entity0 relative to controls in the year poststroke (p = 0.003). CONCLUSIONS: Through an integrated system of education, advice and support to both @entity0 and GP, the ICARUSS model was effective in modifying a variety of vascular risk factors and therefore should decrease the likelihood or recurrent @entity1 or vascular event.

title: Integrated care improves risk-factor modification after XXXX : initial results of the Integrated Care for the Reduction of @entity1 model.

answer: @entity1


abstract: OBJECTIVE: Despite evidence demonstrating that risk-factor management is effective in reducing recurrent @entity2 , there are very few structured care programmes for @entity1 survivors. The aim was to implement and evaluate an integrated care programme in @entity1 . METHODS: 186 @entity0 with @entity1 were randomised to either the treatment (integrated care) or control (usual care) group and were followed up over 12 months. The Integrated Care for the Reduction of @entity1 (ICARUSS) model of integrated care involved collaboration between a specialist @entity1 service, a hospital coordinator and a @entity0 's general practitioner. The primary aim was to promote the management of vascular risk factors through ongoing @entity0 contact and education. RESULTS: In the 12 months poststroke, systolic blood pressure (sBP) decreased in the treatment group but increased in controls. The group difference was significant, and remained so when age, sex, disability and sBP at discharge were accounted for (p = 0.04). Treatment @entity0 also exhibited better modification of body mass index (p = 0.007) and number of walks taken (p<0.001) than controls. Rankin scores indicated significantly @entity3 in treatment @entity0 relative to controls in the year poststroke (p = 0.003). CONCLUSIONS: Through an integrated system of education, advice and support to both @entity0 and GP, the ICARUSS model was effective in modifying a variety of vascular risk factors and therefore should decrease the likelihood or recurrent @entity1 or vascular event.

title: Integrated care improves risk-factor modification after @entity1 : initial results of the Integrated Care for the Reduction of XXXX model.

answer: @entity1


abstract: BACKGROUND/AIMS: Nutritional supplements are widely used. Recently, @entity4 after consumption of Herbalife preparations was reported but the underlying pathogenesis remained cryptic. METHODS: Two @entity0 presented with @entity6 and @entity5 , and @entity2 , respectively. Viral, alcoholic, metabolic, autoimmune, @entity3 and synthetic drugs as the precipitating causes of @entity4 were excluded. However, both @entity0 reported long-term consumption of Herbalife products. All Herbalife products were tested for contamination with drugs, pesticides, heavy metals, and softeners, and examined for microbial contamination according to standard laboratory procedures. Bacteria isolated from the samples were identified as @entity7 by sequencing the 16S rRNA and gyrB genes. RESULTS: Causality between consumption of Herbalife products and disease according to CIOMS was scored "probable" in both cases. Histology showed @entity6 with @entity2 in one @entity0 , and @entity2 with ductopenia in the other. No contamination with chemicals or heavy metals was detected, and immunological testing showed no drug @entity1 . However, samples of Herbalife products ingested by both @entity0 showed growth of @entity7 of which culture supernatants showed dose- and time-dependent hepatotoxicity. CONCLUSIONS: Two novel incidents of severe @entity4 following intake of Herbalife products contaminated with @entity7 emphasize its potential hepatotoxicity.

title: Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with XXXX .

answer: @entity7


abstract: OBJECTIVES: To determine: 1) physician practices regarding the use of radiographs for @entity2 ( @entity2 ), 2) the prevalence of missed @entity3 in @entity0 with a clinical diagnosis of @entity2 , 3) the relative risk of a @entity3 with a nonclassic history for mechanism of injury for @entity2 , and 4) radiographic findings associated with @entity2 that are difficult to reduce. METHODS: This study began with a physician survey that addressed the integration of radiographs into the management of @entity2 . We subsequently conducted a prospective randomized trial with a consecutive sampling of @entity0 less than 6 years of age who presented to one of 2 urban pediatric emergency departments and 2 suburban pediatric urgent care centers with a clinical diagnosis of @entity2 . After informed consent was obtained, reduction was undertaken with a maximum of four attempts (two by hyperpronation and two by supination/flexion), 15 minutes apart. Failure to reduce the @entity2 resulted in the procurement of a radiograph of the elbow. At the conclusion of the study, all radiographs were evaluated by a radiologist blinded to the diagnosis. @entity0 receiving radiographs were contacted 2 weeks after discharge for verification of the diagnosis. RESULTS: Eighty-four percent of 224 physicians returned completed surveys. Fifty-six percent reported using radiographs for failed reduction attempts. In the second phase of the study, 136 @entity0 were enrolled prospectively: 127 were reduced successfully and 9 @entity0 failed attempts at reduction. Of the nine @entity0 receiving radiographs: four had @entity3 (prevalence of 2.9% with 95% confidence interval (CI) = 0.8-7.4), two had no radiographic findings and normal function on follow up, and three had isolated posterior fat pads on radiograph and normal function on follow-up. The relative risk of a @entity3 in @entity0 with a nonclassic history defined as any mechanism other than "pull" was 1.200 (95% CI = 0.441-3.264); the relative risk was 1.886 (95% CI = 0.680-5.231) when defining a nonclassic history as any mechanism other than "pull" or "fall." CONCLUSIONS: 1) Physicians tend to order radiographs for @entity1 they initially perceive to be @entity2 when attempts at reduction fail. 2) In our study, @entity3 in @entity0 who presented with the classic flexed elbow/pronated wrist position were rare. 3) The relative risk of a @entity3 in @entity0 with a nonclassic history for mechanism of injury was not significant. 4) An isolated finding of a posterior fat pad in a @entity0 with @entity2 that is difficult to reduce was not associated with a @entity3 in our small sample of @entity0 with radiographic findings.

title: History and radiographic findings associated with clinically suspected XXXX .

answer: @entity2


abstract: BACKGROUND: @entity11 is a @entity1 characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic @entity0 can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. METHODS: This case report describes severe maxillary and mandibular necrotizing @entity12 and @entity14 in a young female @entity0 after chemotherapy for acute @entity11 . On physical examination, the @entity0 presented malnourished with pale skin, cervical @entity13 , frequent fever and generalized @entity4 . The intra-oral clinical examination found @entity15 , multiple @entity9 , necrotizing @entity12 and @entity14 located in the maxillary and mandibular regions. The necrotizing @entity12 and @entity14 were treated locally with atraumatic removal of the necrotized tissues. The @entity0 received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of @entity10 . She was also treated with systemic @entity8 and @entity3 for 21 days. RESULTS: During the course of management the @entity0 's oral condition improved with some re-epithelialization being noted. However, severe alveolar @entity2 remained evident. Thirty-two months after presentation of the initial symptoms, the @entity0 died due to complications related to @entity11 recurrence ( @entity6 , @entity5 and @entity7 ). CONCLUSIONS: Dental monitoring during @entity1 treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

title: Severe necrotizing @entity12 and @entity14 after chemotherapy for acute XXXX .

answer: @entity11


abstract: BACKGROUND: @entity11 is a @entity1 characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic @entity0 can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. METHODS: This case report describes severe maxillary and mandibular necrotizing @entity12 and @entity14 in a young female @entity0 after chemotherapy for acute @entity11 . On physical examination, the @entity0 presented malnourished with pale skin, cervical @entity13 , frequent fever and generalized @entity4 . The intra-oral clinical examination found @entity15 , multiple @entity9 , necrotizing @entity12 and @entity14 located in the maxillary and mandibular regions. The necrotizing @entity12 and @entity14 were treated locally with atraumatic removal of the necrotized tissues. The @entity0 received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of @entity10 . She was also treated with systemic @entity8 and @entity3 for 21 days. RESULTS: During the course of management the @entity0 's oral condition improved with some re-epithelialization being noted. However, severe alveolar @entity2 remained evident. Thirty-two months after presentation of the initial symptoms, the @entity0 died due to complications related to @entity11 recurrence ( @entity6 , @entity5 and @entity7 ). CONCLUSIONS: Dental monitoring during @entity1 treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

title: Severe necrotizing XXXX and @entity14 after chemotherapy for acute @entity11 .

answer: @entity12


abstract: BACKGROUND: @entity11 is a @entity1 characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic @entity0 can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. METHODS: This case report describes severe maxillary and mandibular necrotizing @entity12 and @entity14 in a young female @entity0 after chemotherapy for acute @entity11 . On physical examination, the @entity0 presented malnourished with pale skin, cervical @entity13 , frequent fever and generalized @entity4 . The intra-oral clinical examination found @entity15 , multiple @entity9 , necrotizing @entity12 and @entity14 located in the maxillary and mandibular regions. The necrotizing @entity12 and @entity14 were treated locally with atraumatic removal of the necrotized tissues. The @entity0 received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of @entity10 . She was also treated with systemic @entity8 and @entity3 for 21 days. RESULTS: During the course of management the @entity0 's oral condition improved with some re-epithelialization being noted. However, severe alveolar @entity2 remained evident. Thirty-two months after presentation of the initial symptoms, the @entity0 died due to complications related to @entity11 recurrence ( @entity6 , @entity5 and @entity7 ). CONCLUSIONS: Dental monitoring during @entity1 treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

title: Severe necrotizing @entity12 and XXXX after chemotherapy for acute @entity11 .

answer: @entity14


abstract: AIM: @entity0 with motor disabilities are at increased risk of compromised bone health. This study evaluated prevalence and risk factors of low bone mass and @entity3 in these @entity0 . METHOD: This cross-sectional cohort study evaluated bone health in 59 @entity0 (38 males, 21 females; median age 10 y 11 mo) with @entity6 (Gross Motor Function Classification System levels II-V). Bone mineral density (BMD) in the lumbar spine was measured with dual-energy X-ray absorptiometry; BMD values were corrected for bone size (bone mineral apparent density [BMAD]) and skeletal maturity, and compared with normative data. Spinal radiographs were obtained to assess vertebral morphology. Blood biochemistry included @entity5 concentration and other parameters of @entity4 homeostasis. RESULTS: Ten @entity0 (17%) had sustained in total 14 peripheral @entity3 ; @entity3 predominated. @entity7 were present in 25%. The median spinal BMAD z-score was -1.0 (range -5.0 to 2.0); it was -0.6 in those without @entity3 and -1.7 in those with @entity3 (p=0.004). @entity5 insufficiency was present in 59% of participants (serum @entity9 <50 nmol/l) and @entity8 in 27%. Low BMAD z-score and @entity8 were independent predictors for @entity3 . INTERPRETATION: @entity0 with @entity6 are at high risk of @entity3 and @entity1 . Evaluation of bone health and prevention of @entity2 should be included in the follow-up.

title: Low bone mass in @entity0 with XXXX : prevalence and risk factors in 59 Finnish @entity0 .

answer: @entity6


abstract: AIM: @entity0 with motor disabilities are at increased risk of compromised bone health. This study evaluated prevalence and risk factors of low bone mass and @entity3 in these @entity0 . METHOD: This cross-sectional cohort study evaluated bone health in 59 @entity0 (38 males, 21 females; median age 10 y 11 mo) with @entity6 (Gross Motor Function Classification System levels II-V). Bone mineral density (BMD) in the lumbar spine was measured with dual-energy X-ray absorptiometry; BMD values were corrected for bone size (bone mineral apparent density [BMAD]) and skeletal maturity, and compared with normative data. Spinal radiographs were obtained to assess vertebral morphology. Blood biochemistry included @entity5 concentration and other parameters of @entity4 homeostasis. RESULTS: Ten @entity0 (17%) had sustained in total 14 peripheral @entity3 ; @entity3 predominated. @entity7 were present in 25%. The median spinal BMAD z-score was -1.0 (range -5.0 to 2.0); it was -0.6 in those without @entity3 and -1.7 in those with @entity3 (p=0.004). @entity5 insufficiency was present in 59% of participants (serum @entity9 <50 nmol/l) and @entity8 in 27%. Low BMAD z-score and @entity8 were independent predictors for @entity3 . INTERPRETATION: @entity0 with @entity6 are at high risk of @entity3 and @entity1 . Evaluation of bone health and prevention of @entity2 should be included in the follow-up.

title: Low bone mass in XXXX with @entity6 : prevalence and risk factors in 59 Finnish @entity0 .

answer: @entity0


abstract: AIM: @entity0 with motor disabilities are at increased risk of compromised bone health. This study evaluated prevalence and risk factors of low bone mass and @entity3 in these @entity0 . METHOD: This cross-sectional cohort study evaluated bone health in 59 @entity0 (38 males, 21 females; median age 10 y 11 mo) with @entity6 (Gross Motor Function Classification System levels II-V). Bone mineral density (BMD) in the lumbar spine was measured with dual-energy X-ray absorptiometry; BMD values were corrected for bone size (bone mineral apparent density [BMAD]) and skeletal maturity, and compared with normative data. Spinal radiographs were obtained to assess vertebral morphology. Blood biochemistry included @entity5 concentration and other parameters of @entity4 homeostasis. RESULTS: Ten @entity0 (17%) had sustained in total 14 peripheral @entity3 ; @entity3 predominated. @entity7 were present in 25%. The median spinal BMAD z-score was -1.0 (range -5.0 to 2.0); it was -0.6 in those without @entity3 and -1.7 in those with @entity3 (p=0.004). @entity5 insufficiency was present in 59% of participants (serum @entity9 <50 nmol/l) and @entity8 in 27%. Low BMAD z-score and @entity8 were independent predictors for @entity3 . INTERPRETATION: @entity0 with @entity6 are at high risk of @entity3 and @entity1 . Evaluation of bone health and prevention of @entity2 should be included in the follow-up.

title: Low bone mass in @entity0 with @entity6 : prevalence and risk factors in 59 Finnish XXXX .

answer: @entity0


abstract: AIM: To undertake a proof-of-concept study to determine whether a removable offloading device (the Ransart boot) for the management of @entity2 ( @entity2 ) was as effective as reports of non-removable devices. RESEARCH DESIGN AND METHODS: This observational study used the Ransart boot for @entity0 with @entity2 , in seven specialist centres. If a @entity0 had two or more @entity1 , one was selected as the index @entity1 . Ulcers were classified by the University of Texas (UT) system. RESULTS: There were 135 @entity0 (mean age 60.3 +/- 11.4 years); 96 (71.1%) male. Median @entity1 duration at presentation was 90 [interquartile range (IQR) 30-1825] days. Seven were lost to follow-up, seven developed other major illnesses and four died; outcomes were documented in the remaining 117. Eighty-two (70.1% of 117) healed, after a median (IQR) 60 (43-99) days, while 22 (18.8%) @entity1 were resolved by amputation (one major). The remaining 13 (11.1%) @entity0 were judged non-compliant. There was a close correlation between @entity1 classification at baseline and both time to healing (P < 0.001 chi(2)-test) and amputation (P < 0.001; Spearman's rank correlation coefficient). There was a positive correlation between @entity1 duration at presentation and time to healing (P < 0.02), UT class (P < 0.01), glycated haemoglobin (P < 0.02) and amputation (P < 0.04). CONCLUSIONS: Time to healing and incidence of amputation were comparable with those previously reported for non-removable devices. Given that a removable device is much more acceptable to the @entity0 , the effectiveness, cost and acceptability of the removable devices, such as the Ransart boot, need to be compared with a non-removable device in a randomized trial. Diabet. Med. 26, 778-782 (2009).

title: A proof-of-concept study of the effectiveness of a removable device for offloading in XXXX with neuropathic ulceration of the foot: the Ransart boot.

answer: @entity0


abstract: Acute @entity3 frequently causes life-threatening organ @entity1 . The optimal therapy for acute type-B @entity3 is still controversial. Early surgery for acute dissections with organ malperfusion is known to carry a high morbidity and mortality. Endovascular treatment, such as stent placement for branch stenosis, percutaneous balloon fenestration for compression of the true channel and aortic stent placement to support collapsed true channel, is becoming an alternative form of treatment. However, it is not clear whether endovascular intervention alone is effective in the long term. We herein report a case of emergency percutaneous endovascular stenting with intentional surgical delay in a @entity0 who had visceral and lower extremity malperfusion due to acute type-B dissection. A 10x57 mm bare metal stent was inserted into the obliterated true channel of the thoracoabdominal aorta 3 h after onset of symptoms. It immediately relieved the abdominal and lower limb @entity1 symptoms. The advantage of small-sized stent placement is its easiness and being gentle to fragile intima. The small-sized stent placement for @entity0 with @entity2 with visceral organ @entity1 may be a promising 'bridging therapy' before they undergo traditional central repair.

title: Endovascular stent placement for acute type-B XXXX with malperfusion--an intentional surgical delay and a possible 'bridging therapy'.

answer: @entity3


abstract: Double-particle @entity1 ( @entity1 ) was performed for the detection of an intact heterodimeric form of @entity0 chorionic gonadotropin (intact hCG) composed in Profasi hCG (P-hCG). This technique relied on two mixed types of @entity0 O RBC, which were individually coated with two distinct monoclonal antibodies that recognized alpha or beta subunit of hCG, i.e. @entity2 and BEL-5, respectively. The positive hemagglutination result was achieved by this technique. However, in the BEL-5 coated single-particle control system, positive results for both P-hCG and beta subunit hCG solution were realized. The occurrence of beta-multimer hCG was a causative molecule revealed by the hemagglutination inhibition technique. Thereby, the novel method called "combined immunoprecipitation and agglutination" was developed to overcome this problem. The free beta subunit together with the betamultimer hCG were eliminated from other forms presented in P-hCG after using the @entity2 coated particles. The precipitated particles, which captured the heterodimer hCG molecule, reacted further with soluble BEL-5 to subsequently form a trellis. A positive result was obtained only with P-hCG, but not with beta subunit hCG or hLH. This study is inferable as a model for the detection of heterodimeric molecule by an elementary method.

title: Combined immunoprecipitation and agglutination for the detection of the heterodimeric molecule: XXXX chorionic gonadotropin as a study model.

answer: @entity0


abstract: Abstract The distribution of bacterial populations and activity were determined at two Ocean Drilling Program sites (1109 and 1115) in the Woodlark extensional Basin, near Papua New Guinea, Pacific Ocean. These relatively deep water (1 150-2 211 m), low organic @entity0 ( approximately 0.4%), low organic matter sedimentation sites, with average thermal gradients ( approximately 30 degrees C/km) are representative of large areas of ocean sediments. At a third site, 1118, with a higher thermal gradient (63 degrees C/km), only bacterial distributions and pore water @entity2 (bioavailable) concentrations were determined. Active bacterial populations were present to all depths at Sites 1109 and 1115, maximum depth 801 mbsf (metres below seafloor), and this represents the deepest and oldest marine sediments ( approximately 15 Ma) in which the presence of bacteria has been demonstrated using a combination of different approaches (direct microscopic and viable counts, radiotracer turnover and geochemical analysis). In addition, direct counts and geochemical data at Site 1118 provide strong evidence for significant bacterial populations to at least 842 mbsf (3.2x10(5)/cm(3)). Similar to previously studied subseafloor sediments, maximum bacterial populations and activity occurred in the upper approximately 20 m, with much lower rates (up to 10 000 times) in deeper layers. However, a depth integration of data demonstrated that the majority of bacterial cells and activity ( @entity1 reduction, methanogenesis, @entity3 incorporation into DNA and @entity2 oxidation) occurred in the subsurface, below 20 m. For @entity1 reduction this was dependent on the depth of @entity1 penetration. @entity2 was an important substrate for methanogenesis. Despite being degraded, @entity2 concentrations in subsurface layers remained relatively constant (<10 @entity4 ) and therefore, there must also have been deep @entity2 formation, which is consistent with the presence of acetogenic bacteria. These results extend the significance of deep @entity2 formation for the maintenance of subsurface bacterial populations to sediments representative of large areas of the ocean.

title: Geomicrobiology of deep, low organic XXXX sediments in the Woodlark Basin, Pacific Ocean.

answer: @entity0


abstract: Kinetic analyses of bacterial growth, @entity4 consumption, and metabolite production of 18 @entity7 strains grown on @entity2 , @entity6 , or inulin were performed. A principal component analysis of the data sets, expanded with the results of a genetic screen concerning the presence of a beta-fructofuranosidase gene previously encountered in @entity7 (T), revealed the existence of four clusters among the bifidobacteria tested. Strains belonging to a first cluster could not degrade @entity6 or inulin. Strains in a second cluster could degrade @entity6 , displaying a preferential breakdown mechanism, but did not grow on inulin. @entity2 consumption was faster than @entity6 degradation. A third cluster was composed of strains that degraded all @entity6 fractions simultaneously and could partially break down inulin. @entity6 degradation was substantially faster than @entity2 consumption. A fourth, smaller cluster consisted of strains that shared high @entity2 consumption and @entity6 degradation rates and were able to perform partial breakdown of inulin. For all strains, a metabolic shift toward more @entity0 , @entity5 , and @entity3 production, at the expense of @entity1 production, was observed during growth on less readily fermentable energy sources. No correlation between breakdown patterns and the presence of the beta-fructofuranosidase gene could be detected. These variations indicate niche-specific adaptation of bifidobacteria and could have in vivo implications on the strain specificity of the stimulatory effect of inulin-type fructans on bifidobacteria.

title: In vitro kinetic analysis of fermentation of prebiotic inulin-type fructans by XXXX species reveals four different phenotypes.

answer: @entity7


abstract: RATIONALE: It is commonly stated that mortality from @entity3 ( @entity3 ) and @entity2 ( @entity2 ) is decreasing. OBJECTIVES: To systematically review the literature assessing @entity3 mortality over time and to determine @entity0 - and study-level factors independently associated with mortality. METHODS: We searched multiple databases (MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL) for prospective observational studies or @entity1 ( @entity1 ) published during the period 1984 to 2006 that enrolled 50 or more @entity0 with @entity2 / @entity3 and reported mortality. We pooled mortality estimates using random-effects meta-analysis and examined mortality trends before and after 1994 (when a consensus definition of @entity2 / @entity3 was published) and factors associated with mortality using meta-regression models. MEASUREMENTS AND MAIN RESULTS: Of 4,966 studies, 89 met inclusion criteria (53 observational, 36 @entity1 ). There was a total of 18,900 @entity0 (mean age 51.6 years; 39% female). Overall pooled weighted mortality was 44.3% (95% confidence interval [CI], 41.8-46.9). Mortality decreased with time in observational studies conducted before 1994; no temporal associations with mortality were demonstrated in @entity1 (any time) or observational studies (after 1994). Pooled mortality from 1994 to 2006 was 44.0% (95% CI, 40.1-47.5) for observational studies, and 36.2% (95% CI, 32.1-40.5) for @entity1 . Meta-regression identified study type (observational versus RCT, odds ratio, 1.36; 95% CI, 1.08-1.73) and @entity0 age (odds ratio per additional 10 yr, 1.27; 95% CI, 1.07-1.50) as the only factors associated with mortality. CONCLUSIONS: A decrease in @entity3 mortality was only seen in observational studies from 1984 to 1993. Mortality did not decrease between 1994 (when a consensus definition was published) and 2006, and is lower in @entity1 than observational studies.

title: Has mortality from XXXX decreased over time?: A systematic review.

answer: @entity3


abstract: PURPOSE: To determine the feasibility and report clinical outcomes of @entity5 computed tomographic (CT) angiography with 64-section multidetector CT technology in the evaluation of @entity0 sustaining penetrating @entity1 . MATERIALS AND METHODS: This HIPAA-compliant retrospective study was approved by the institutional review board and consent was waived. All adult @entity1 @entity0 who sustained penetrating @entity1 to the @entity5 and who underwent CT angiography based on the recommendation of the attending @entity1 surgeon after the initial clinical examination were included. All studies were acquired with 64-section CT technology between April 2005 and September 2007 at our level I @entity1 center. Two radiologists in consensus retrospectively reviewed all the CT angiograms for evidence of @entity4 . Attenuation was measured with regions of interest placed within the arterial lumen of multiple segments of the @entity5 arteries. Hospital course and disposition were determined by reviewing the @entity0 ' medical records, with a mean follow-up of 33 days. RESULTS: This study included 59 @entity0 (54 @entity0 , five @entity0 ; mean age, 27 years). Nineteen (32%) @entity0 had the following @entity4 at CT angiography: @entity2 (n = 7), arterial extravasation (n = 6), isolated @entity6 formation (n = 2), isolated focal @entity3 (n = 2), occlusion and @entity6 formation (n = 1), and focal @entity3 and @entity6 formation (n = 1). Of these 19 @entity0 , seven underwent surgical treatment. Evaluation of the technical quality of the @entity5 angiograms demonstrated mean attenuation values of 244 HU. In 48 (81%) of 59 @entity0 , mean attenuation values were higher than 200 HU, with four (7%) @entity0 having mean attenuation values lower than 150 HU. CONCLUSION: Upper extremity CT angiograms obtained with 64-section CT demonstrated adequate technical quality in the majority of @entity0 and performed well clinically in @entity0 with penetrating @entity1 .

title: Upper extremity CT angiography in penetrating XXXX : use of 64-section multidetector CT.

answer: @entity1


abstract: INTRODUCTION AND OBJECTIVES: Both 8-mm-tip and irrigated-tip catheters improve outcomes in typical @entity3 . However, it is not yet known which is preferable. The objective was to compare the effectiveness of 8-mm-tip (Group 1) and open irrigated-tip (Group 2) catheters in the first ablation attempt. METHODS: A prospective randomized trial with a long-term follow-up was performed in @entity0 with documented typical @entity3 . For both types of catheter, the power was initially set to 50 W. The primary endpoint was ablation of the cavotricuspid isthmus in a procedure lasting, at most, 600 s. RESULTS: Group 1 contained 65 @entity0 and Group 2 contained 66, with no significant intergroup difference in baseline characteristics. Their mean age was 63+/-12 years, 80% were @entity0 , and 65% had structural @entity1 . The primary endpoint was achieved in 48 @entity0 (73.8%) in Group 1 and 49 (74.2%) in Group 2 (P=NS). In the remaining @entity0 , the procedure was continued at the physician's discretion and ablation was finally achieved in all cases. In the intention-to-treat analysis, there was no significant difference between the groups in the number of applications of the ablation device or in the duration of the ablation procedure, radioscopy or the total procedure. By 16+/-5 months of follow-up (>1 year in 98%), 8 (6.3%) @entity0 had experienced recurrence and 95 (74.2%) were free from any @entity2 . There was no differences between the groups. CONCLUSIONS: No difference was found between the effectiveness of 8-mm-tip and open irrigated-tip catheters in the first attempt at ablation of typical @entity3 .

title: Comparison of 8-mm-tip and irrigated-tip catheters in the ablation of isthmus-dependent XXXX : a prospective randomized trial.

answer: @entity3


abstract: In our study, we examined socioeconomic, treatment-related, and psychologic experiences of parents during the @entity1 treatment of their @entity0 in an academic hospital in Indonesia. @entity0 were treated with the WK-ALL-2000 protocol and received donated chemotherapy. From November 2004 to April 2006, 51 parents were interviewed by psychologists using semi-structured questionnaires. The family income had decreased (69%) since the start of treatment. Parents lost their jobs (29% of fathers and 8% of mothers), most of whom stated that this loss of employment was caused by the @entity2 of their @entity0 (87% of fathers and 100% of mothers). Treatment costs resulted in financial difficulties (78%), debts (65%), and forced parents either to postpone or withdraw from parts of treatment (18%). Parents mentioned needing more information (86%) from and contact (77%) with doctors. The parent organization did not pay any visits (69%) during hospitalization, nor did they give information (59%) or emotional support (55%). We have concluded that the socioeconomic impact of @entity2 treatment was profound. Communication between parents and doctors requires improving. The role of the parent organization was insignificant and must be ameliorated.

title: Parental experiences of XXXX treatment in indonesia.

answer: @entity2


abstract: Severe reactions in exercise-induced @entity2 (EIA) seem to be underestimated in the published literature. We report two cases of near-miss death from EIA that occurred after a short run. We review 364 exercise tests that were performed between September 1987 and October 1988 by a standardised protocol on a treadmill, on @entity0 with possible EIA. A positive test, defined by a fall of FEV1 of at least 20% was found in 173 @entity0 . From 21 @entity0 with a fall of greater than 50%, 4 presented severe signs of: Cyanosis. Intense @entity3 with impediment of speech. General malaise with @entity1 . These 4 @entity0 were not greatly different from @entity0 of the 50% fall group when compared for FEV1 before the test and for heart-rate during the test. They differed in the duration of the @entity2 , which was more protracted, despite the use of @entity4 agonists. The onset of severe reactions is 2.3% of positive tests and seems to be unpredictable.

title: [Severe forms of effort-induced XXXX ].

answer: @entity2


abstract: BACKGROUND AND AIM: To describe @entity2 ( @entity2 ) mortality trends during 1985-2004 and to estimate @entity2 mortality projections for the period 2005-2019 in Spain. MATERIAL AND METHODS: A Bayesian age-period-cohort analysis has been carried out to investigate the effect of the age, period, and birth cohort on @entity2 mortality in Spain. Mortality projections until 2019 were based on the age-period-cohort model. RESULTS: During 1985-1994, @entity2 mortality increased in both sexes (3.9% yearly in @entity0 and 1.5% in @entity0 ). After 1995, @entity2 mortality increased in @entity0 (1.6%) and leveled off in @entity0 (-0.6%). @entity4 mortality increased for the whole period in @entity0 , this increase being lower in the second decade (1985-1994: 5.0%; 1995-2004: 1.8%). In @entity0 , @entity4 mortality increased in the first decade (2.8%) and leveled off during the second decade (-0.1%). @entity1 mortality increased in @entity0 (1.2%) and decreased in @entity0 (-1.1%) during the whole study period. Projections showed an increase in the number of @entity2 in @entity0 older than 60 years and a level off in @entity0 . CONCLUSION: Although mass screening for @entity2 in Spain has not been available, the favorable recent changes in @entity2 mortality trends observed after 1995 could be related to progress in diagnosis and treatment. The projected number of @entity3 could be used as reference scenario for assessing future impact of new treatments as well as the potential impact of future population-based screening when introduced.

title: XXXX mortality in Spain: trends and projections for 1985-2019.

answer: @entity2


abstract: Inhibition of osteoblast-mediated mineralization is one of the major catabolic effects of @entity7 ( @entity7 ) on bone. Previously, we showed that @entity7 induces matrix @entity11 ( @entity6 ) protein ( @entity12 ) expression and established that this induction is critical for @entity7 -mediated inhibition of osteoblast mineralization. In the present study, we focus on the mechanism through which @entity7 regulates @entity12 expression in osteoblastic @entity0 cells. Following transient transfection of these cells with a -748 bp @entity0 @entity12 promoter-luciferase construct (pMGP-luc), @entity7 (10 (-7) M) induced promoter activity in a time-dependent manner with a maximal four- to six fold induction seen 6 h after @entity7 treatment. Both @entity5 (PKA inhibitor) and @entity4 ( @entity10 inhibitor), suppressed @entity7 induction of @entity12 promoter activity as well as the @entity12 mRNA level. In addition, @entity2 (PKA activator) stimulated @entity12 promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of @entity12 by @entity7 . Co-transfection of @entity0 cells with pMGP-luc and @entity10 (SP), a plasmid encoding the constitutively active form of @entity10 , led to a dose-dependent increase in @entity12 promoter activity. Both @entity12 promoter activity and @entity12 mRNA level were not affected by the protein kinase C (PKC) inhibitor, @entity8 . However, @entity1 ( @entity3 ), a selective PKC activator induced @entity12 mRNA expression through activation of @entity9 ( @entity9 ). Taken together, these results indicate that @entity7 regulates @entity12 via both PKA- and @entity9 -dependent pathways.

title: Regulation of matrix Gla protein by XXXX in @entity0 osteoblast-like cells involves protein kinase A and @entity9 pathways.

answer: @entity7


abstract: Inhibition of osteoblast-mediated mineralization is one of the major catabolic effects of @entity7 ( @entity7 ) on bone. Previously, we showed that @entity7 induces matrix @entity11 ( @entity6 ) protein ( @entity12 ) expression and established that this induction is critical for @entity7 -mediated inhibition of osteoblast mineralization. In the present study, we focus on the mechanism through which @entity7 regulates @entity12 expression in osteoblastic @entity0 cells. Following transient transfection of these cells with a -748 bp @entity0 @entity12 promoter-luciferase construct (pMGP-luc), @entity7 (10 (-7) M) induced promoter activity in a time-dependent manner with a maximal four- to six fold induction seen 6 h after @entity7 treatment. Both @entity5 (PKA inhibitor) and @entity4 ( @entity10 inhibitor), suppressed @entity7 induction of @entity12 promoter activity as well as the @entity12 mRNA level. In addition, @entity2 (PKA activator) stimulated @entity12 promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of @entity12 by @entity7 . Co-transfection of @entity0 cells with pMGP-luc and @entity10 (SP), a plasmid encoding the constitutively active form of @entity10 , led to a dose-dependent increase in @entity12 promoter activity. Both @entity12 promoter activity and @entity12 mRNA level were not affected by the protein kinase C (PKC) inhibitor, @entity8 . However, @entity1 ( @entity3 ), a selective PKC activator induced @entity12 mRNA expression through activation of @entity9 ( @entity9 ). Taken together, these results indicate that @entity7 regulates @entity12 via both PKA- and @entity9 -dependent pathways.

title: Regulation of matrix Gla protein by @entity7 in @entity0 osteoblast-like cells involves protein kinase A and XXXX pathways.

answer: @entity9


abstract: Inhibition of osteoblast-mediated mineralization is one of the major catabolic effects of @entity7 ( @entity7 ) on bone. Previously, we showed that @entity7 induces matrix @entity11 ( @entity6 ) protein ( @entity12 ) expression and established that this induction is critical for @entity7 -mediated inhibition of osteoblast mineralization. In the present study, we focus on the mechanism through which @entity7 regulates @entity12 expression in osteoblastic @entity0 cells. Following transient transfection of these cells with a -748 bp @entity0 @entity12 promoter-luciferase construct (pMGP-luc), @entity7 (10 (-7) M) induced promoter activity in a time-dependent manner with a maximal four- to six fold induction seen 6 h after @entity7 treatment. Both @entity5 (PKA inhibitor) and @entity4 ( @entity10 inhibitor), suppressed @entity7 induction of @entity12 promoter activity as well as the @entity12 mRNA level. In addition, @entity2 (PKA activator) stimulated @entity12 promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of @entity12 by @entity7 . Co-transfection of @entity0 cells with pMGP-luc and @entity10 (SP), a plasmid encoding the constitutively active form of @entity10 , led to a dose-dependent increase in @entity12 promoter activity. Both @entity12 promoter activity and @entity12 mRNA level were not affected by the protein kinase C (PKC) inhibitor, @entity8 . However, @entity1 ( @entity3 ), a selective PKC activator induced @entity12 mRNA expression through activation of @entity9 ( @entity9 ). Taken together, these results indicate that @entity7 regulates @entity12 via both PKA- and @entity9 -dependent pathways.

title: Regulation of matrix Gla protein by @entity7 in XXXX osteoblast-like cells involves protein kinase A and @entity9 pathways.

answer: @entity0


abstract: One hundred and twenty-eight @entity0 undergoing assessment for genetic risk of @entity2 completed questionnaires at entry into the assessment process and following risk provision. The key variable of interest was the level of intrusive worries at each time, and factors associated with the level of intrusive worries following risk provision. Based on the CARA model (Renner, Pers Soc Psychol Bull 30:384-396, 2004), it was expected that an unexpected risk assessment (whether good or bad) would result in high levels of intrusive thoughts. Other potential moderators of worry included @entity1 , level of threat experienced (low control, high perceived risk), the use of differing coping efforts, and the available social support. Of note was that while levels of intrusive thoughts fell in all risk groups following risk provision, unexpectedly only @entity0 found to be at population risk reported an increase of active attempts to distract from intrusive worries at this time. The CARA model was not supported. However, intrusion scores were independently associated with higher levels of @entity1 , a lack of confidant support, and a confrontive coping response. Active avoidance scores were uniquely associated with being assigned as population risk, @entity1 , lack of confidant and affective support, and the use of avoidant coping. Together, these variables accounted for 33% of the variance in intrusion scores and 31% of the variance in avoidance scores. The implications of these findings is discussed.

title: Factors associated with intrusive cancer-related worries in XXXX undergoing cancer genetic risk assessment.

answer: @entity0


abstract: BACKGROUND: A rare and peculiar @entity1 has begun to be recognized in Japan. The Japanese Society of Nephrology has established a research working group and has collected cases from all over Japan in an attempt to understand the complete spectrum of this @entity1 . METHOD: The diagnostic criterion, which was needed to collect the cases, was proposed as a @entity1 showing microspheres or microtubular structures or both associated with podocytic infolding into the glomerular basement membrane (GBM) on electron microscopy. The lesion shows a non-argentaffin hole in the GBM with periodic acid @entity5 staining and is similar to @entity3 . RESULTS: Twenty-five cases were collected from 17 institutions. @entity0 were 20-69 years old (19 @entity0 , 6 @entity0 ). Seventeen @entity0 also had collagen diseases such as @entity7 and @entity2 . All @entity0 had @entity4 . @entity4 showed a remission in 15 of 23 @entity0 within 12 months, but @entity4 remained higher than 1.0 g/day in five @entity0 despite different types of therapy. Podocytic infolding including microspheres showed either positive or negative staining for immunoglobulins. Cluster formation of microspheres was found in 4 of 17 @entity0 with @entity6 , and in five out eight @entity0 without @entity6 . Electron-dense deposits in the GBM were also found in 6 of 17 @entity0 with @entity6 but were not found in eight @entity0 without @entity6 . CONCLUSION: Some @entity0 might have a subtype of @entity7 , class V, or @entity3 . However, we propose a new disease entity, podocytic infolding @entity1 , as a common basis of all 25 @entity0 , because we suspect that microspheres or microtubular structures or both can be derived from podocytic infolding.

title: Proposal of podocytic infolding XXXX as a new disease entity: a review of 25 cases from nationwide research in Japan.

answer: @entity1


abstract: PURPOSE: To retrospectively assess the local control and intermediate- and long-term survival of @entity1 with liver metastases from @entity0 who have undergone percutaneous ultrasonography (US)-guided radiofrequency (RF) ablation. MATERIALS AND METHODS: This study was approved by the hospital ethics committee, and all @entity1 provided written informed consent. RF ablation was used to treat 87 @entity0 (mean diameter, 2.5 cm) in 52 female @entity1 (median age, 55 years). Inclusion criteria were as follows: fewer than @entity3 , maximum @entity3 diameter of 5 cm or smaller, and disease either confined to the liver or stable with medical therapy. Forty-five (90%) of 50 @entity1 had previously undergone chemotherapy, hormonal therapy, or both, and had no response or an incomplete response to the treatment. Contrast material-enhanced computed tomography and US were performed to evaluate complications and technical success and to assess for local @entity3 progression during follow-up. The Kaplan-Meier method was used to assess survival, and results were compared between groups with a log-rank test. Cox regression analysis was used to assess independent prognostic factors that affected survival. RESULTS: Complete @entity3 @entity4 was achieved in 97% of @entity3 . Two (4%) minor complications occurred. Median time to follow-up from diagnosis of liver @entity2 and from RF ablation was 37.2 and 19.1 months, respectively. Local @entity3 progression occurred in 25% of @entity1 . New intrahepatic metastases developed in 53% of @entity1 . From the time of first RF ablation, overall median survival time and 5-year survival rate were 29.9 months and 27%, respectively. From the time the first liver @entity2 was diagnosed, overall median survival time was 42 months, and the 5-year survival rate was 32%. @entity1 with @entity3 2.5 cm in diameter or larger had a worse prognosis (hazard ratio, 2.1) than did @entity1 with @entity3 smaller than 2.5 cm in diameter. CONCLUSION: Survival rates in selected @entity1 with @entity0 treated with RF ablation are comparable to those reported in the literature that were achieved with surgery or laser ablation.

title: XXXX : US-guided percutaneous radiofrequency ablation--intermediate and long-term survival rates.

answer: @entity0


abstract: PURPOSE: To investigate the feasibility of magnetically labeling stem cells with superparamagnetic @entity2 (SPIO) by means of microbubble-enhanced ultrasonographic (US) exposure (MUE) and to study the effects of this approach--without secondary transfection agents--on the viability, proliferation activity, and differentiation capability of @entity3 -labeled stem cells. MATERIALS AND METHODS: Institutional review board approval was obtained for this study. @entity0 mesenchymal stem cells (MSCs) ([1 to 2] x 10(6)/mL) were studied in four experiment groups: sham exposure to US with microbubbles and SPIO (group A), exposure to US with SPIO but without microbubbles (group B), exposure to US with microbubbles and SPIO (group C), and sham exposure to US without SPIO or microbubbles (group D). Intracellular @entity1 uptake was analyzed qualitatively at light and electron microscopy. The viability and proliferation activity of MSCs were evaluated. The adipogenic and osteogenic differentiation capability of the labeled MSCs was also evaluated. Ninety-five percent confidence intervals were derived for assessment of differences in cell viability and proliferation activity between groups C and D. RESULTS: Light and electron microscopy revealed intracytoplasmic @entity1 uptake and nearly 100% cell labeling efficiency. The MUE-labeled MSCs had unaltered viability and uncompromised proliferation activity compared with the nonlabeled MSCs. Similar to the nonlabeled MSCs, the MUE-labeled MSCs differentiated into adipogenic and osteogenic lineages. CONCLUSION: Initial study results show that stem cells can be effectively labeled with SPIO by using MUE without secondary transfection agents and thus that MUE labeling is an appealing alternative cell-labeling approach that warrants investigation for intracellular magnetic labeling of stem cells. SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2531081974/-/DC1.

title: In vitro labeling of mesenchymal stem cells with superparamagnetic XXXX by means of microbubble-enhanced US exposure: initial experience.

answer: @entity2