abstract: UNASSIGNED: Psychedelic agents have a long history of use by @entity0 for their capacity to induce profound modifications in perception, emotion and cognitive processes. Despite increasing knowledge of the neural mechanisms involved in the acute effects of these drugs, the impact of sustained psychedelic use on the @entity0 brain remains largely unknown. Molecular pharmacology studies have shown that psychedelic @entity2 ( @entity2 )2A agonists stimulate neurotrophic and transcription factors associated with synaptic plasticity. These data suggest that psychedelics could potentially induce structural changes in brain tissue. Here we looked for differences in @entity1 ( @entity1 ) in regular users of psychedelics. We obtained magnetic resonance imaging (MRI) images of the brains of 22 regular users of ayahuasca (a preparation whose active principle is the psychedelic 5HT2A agonist @entity4 ( @entity3 )) and 22 controls matched for age, sex, years of education, verbal IQ and fluid IQ. Ayahuasca users showed significant @entity1 differences in midline structures of the brain, with thinning in the posterior cingulate cortex (PCC), a key node of the default mode network. @entity1 values in the PCC were inversely correlated with the intensity and duration of prior use of ayahuasca and with scores on self-transcendence, a personality trait measuring religiousness, transpersonal feelings and spirituality. Although direct causation cannot be established, these data suggest that regular use of psychedelic drugs could potentially lead to structural changes in brain areas supporting attentional processes, self-referential thought, and internal mentation. These changes could underlie the previously reported personality changes in long-term users and highlight the involvement of the PCC in the effects of psychedelics.

title: Long-term use of psychedelic drugs is associated with differences in brain structure and personality in XXXX .

answer: @entity0


abstract: BACKGROUND: Atherosclerotic carotid @entity3 may lead to @entity5 , causing transient @entity1 attack or @entity2 . Carotid plaque ulceration on angiography is associated with @entity3 . Although healing of @entity3 has been described in coronary arteries, little is known about the natural development of plaque ulcerations in carotid arteries. We therefore explored the evolution of carotid plaque surface morphology with serial multidetector CT angiography (MDCTA). METHODS: From a registry of @entity0 with transient @entity1 attack or minor @entity2 , we selected 83 @entity0 who had undergone serial MDCTA of the carotid arteries. Arteries subjected to revascularization procedures between the two scans were excluded (n = 11). Plaque surface morphology was classified as smooth, irregular or ulcerated on both baseline and follow-up MDCTA. Progression (i.e. development of irregularities or ulceration) and regression (i.e. disappearance of irregularities or ulceration) in morphology were evaluated. RESULTS: The mean time interval between the MDCTA scans was 21    13 months. At baseline, 28 (18%) arteries were normal, 124 (80%) contained @entity4 plaque and 3 (2%) were occluded. Plaque surface morphology was smooth in 86 arteries (55%), irregular in 23 (15%) and ulcerated in 15 (10%). At follow-up, surface morphology was unchanged in 88% of arteries, had progressed in 8% and regressed in 4%. Most importantly, plaque morphology remained unchanged in most ulcerated plaques (10/15; 67%). One @entity6 had progressed, whereas 4 had regressed. New ulcerations had developed in 2 nonulcerated plaques. CONCLUSION: MDCTA allows evaluation of temporal changes in @entity4 carotid plaque morphology. Plaque surface morphology remained unchanged in most arteries. Carotid ulcerations persist for a long time, and may remain a potential source of @entity5 .

title: Evolution of XXXX carotid plaque morphology: do ulcerated plaques heal? A serial multidetector CT angiography study.

answer: @entity4


abstract: OBJECTIVE: To estimate the cumulative incidence of @entity1 for @entity0 and @entity0 in a population-based sample. DESIGN: Longitudinal study of a birth cohort. SETTING: Research unit. @entity0 (S): A population-based birth cohort of 1,037 @entity0 and @entity0 born in Dunedin, New Zealand, between 1972 and  1973. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Cumulative incidence of @entity1 by age 32 and 38, distribution of causes and service use for @entity1 , live birth subsequent to @entity1 , and live birth by age  38. RESULT(S): The cumulative incidence of @entity1 by age 38 ranged from 14.4% to 21.8% for @entity0 and from 15.2% to 26.0% for @entity0 depending on the @entity1 definition and data used. Infertility, defined as having tried to conceive for 12  months or more or having sought medical help to conceive, was experienced by 21.8% (95% confidence interval [CI], 17.7-26.2) of @entity0 and 26.0% (95% CI, 21.8-30.6) of @entity0 by age 38. For those who experienced @entity1 , 59.8% (95% CI, 48.3-70.4) of @entity0 and 71.8% (95% CI, 62.1-80.3) of @entity0 eventually had a live birth. Successful resolution of @entity1 and entry into parenthood by age 38 were much lower for those who first experienced @entity1 in their mid to late thirties compared with at a younger age. CONCLUSION(S): Comparison of reports from two assessments in this cohort study suggests @entity1 estimates from a single cross-sectional study may underestimate lifetime @entity1 . The lower rate of resolution and entry into parenthood for those first experiencing @entity1 in their mid to late thirties highlights the consequences of postponing parenthood and could result in involuntary childlessness and fewer @entity0 than desired.

title: Cumulative incidence of XXXX in a New Zealand birth cohort to age 38 by sex and the relationship with family formation.

answer: @entity1


abstract: UNASSIGNED: @entity6 has been added to hormone replacement therapy to treat @entity5 in postmenopausal @entity0 . Whereas @entity4 has been associated with vascular protection, the vascular effects of @entity6 are contradictory and the effects of its association with @entity4 are largely unknown. In this study we determined the effects of @entity6 associated with conjugated @entity9 @entity4 (CEE) on vascular function using a model of @entity3 postmenopausal female: ovariectomized spontaneously @entity3 @entity2 . Female spontaneously @entity3 @entity2 were divided into sham-operated, ovariectomized (OVX), and OVX treated for 15 days with either CEE alone (OVX+CEE) or associated with @entity6 (OVX+CEE+T). @entity10 ( @entity10 )-induced contraction was markedly increased in aortic rings from OVX compared with sham-operated @entity2 . CEE treatment restored @entity10 responses, a beneficial effect abrogated with CEE+T. CEE treatment also increased endothelium-dependent relaxation, which was impaired in OVX @entity2 . This effect was lost by CEE+T. Treatment of aortas with @entity11 ( @entity10 type-1 receptor antagonist) or @entity13 ( @entity8 -oxidase inhibitor) restored the endothelium-dependent relaxation in OVX and CEE+T, establishing an interplay between @entity10 and @entity7 in OVX and CEE+T. The benefits by CEE were associated with downregulation of @entity8 -oxidase subunits mRNA expression and decreased reactive @entity1 species generation. The association of @entity6 with CEE impairs the benefits of @entity4 on OVX-associated @entity7 and reactive @entity1 species generation in @entity2 aorta by a mechanism that involves phosphorylation of the cytosolic @entity8 -oxidase subunit @entity12 (phox).

title: Association of XXXX with @entity4 abolishes the beneficial effects of @entity4 treatment by increasing ROS generation in aorta endothelial cells.

answer: @entity6


abstract: UNASSIGNED: @entity6 has been added to hormone replacement therapy to treat @entity5 in postmenopausal @entity0 . Whereas @entity4 has been associated with vascular protection, the vascular effects of @entity6 are contradictory and the effects of its association with @entity4 are largely unknown. In this study we determined the effects of @entity6 associated with conjugated @entity9 @entity4 (CEE) on vascular function using a model of @entity3 postmenopausal female: ovariectomized spontaneously @entity3 @entity2 . Female spontaneously @entity3 @entity2 were divided into sham-operated, ovariectomized (OVX), and OVX treated for 15 days with either CEE alone (OVX+CEE) or associated with @entity6 (OVX+CEE+T). @entity10 ( @entity10 )-induced contraction was markedly increased in aortic rings from OVX compared with sham-operated @entity2 . CEE treatment restored @entity10 responses, a beneficial effect abrogated with CEE+T. CEE treatment also increased endothelium-dependent relaxation, which was impaired in OVX @entity2 . This effect was lost by CEE+T. Treatment of aortas with @entity11 ( @entity10 type-1 receptor antagonist) or @entity13 ( @entity8 -oxidase inhibitor) restored the endothelium-dependent relaxation in OVX and CEE+T, establishing an interplay between @entity10 and @entity7 in OVX and CEE+T. The benefits by CEE were associated with downregulation of @entity8 -oxidase subunits mRNA expression and decreased reactive @entity1 species generation. The association of @entity6 with CEE impairs the benefits of @entity4 on OVX-associated @entity7 and reactive @entity1 species generation in @entity2 aorta by a mechanism that involves phosphorylation of the cytosolic @entity8 -oxidase subunit @entity12 (phox).

title: Association of @entity6 with XXXX abolishes the beneficial effects of @entity4 treatment by increasing ROS generation in aorta endothelial cells.

answer: @entity4


abstract: UNASSIGNED: @entity6 has been added to hormone replacement therapy to treat @entity5 in postmenopausal @entity0 . Whereas @entity4 has been associated with vascular protection, the vascular effects of @entity6 are contradictory and the effects of its association with @entity4 are largely unknown. In this study we determined the effects of @entity6 associated with conjugated @entity9 @entity4 (CEE) on vascular function using a model of @entity3 postmenopausal female: ovariectomized spontaneously @entity3 @entity2 . Female spontaneously @entity3 @entity2 were divided into sham-operated, ovariectomized (OVX), and OVX treated for 15 days with either CEE alone (OVX+CEE) or associated with @entity6 (OVX+CEE+T). @entity10 ( @entity10 )-induced contraction was markedly increased in aortic rings from OVX compared with sham-operated @entity2 . CEE treatment restored @entity10 responses, a beneficial effect abrogated with CEE+T. CEE treatment also increased endothelium-dependent relaxation, which was impaired in OVX @entity2 . This effect was lost by CEE+T. Treatment of aortas with @entity11 ( @entity10 type-1 receptor antagonist) or @entity13 ( @entity8 -oxidase inhibitor) restored the endothelium-dependent relaxation in OVX and CEE+T, establishing an interplay between @entity10 and @entity7 in OVX and CEE+T. The benefits by CEE were associated with downregulation of @entity8 -oxidase subunits mRNA expression and decreased reactive @entity1 species generation. The association of @entity6 with CEE impairs the benefits of @entity4 on OVX-associated @entity7 and reactive @entity1 species generation in @entity2 aorta by a mechanism that involves phosphorylation of the cytosolic @entity8 -oxidase subunit @entity12 (phox).

title: Association of @entity6 with @entity4 abolishes the beneficial effects of XXXX treatment by increasing ROS generation in aorta endothelial cells.

answer: @entity4


abstract: OBJECTIVE: To determine blood products used, clinical outcomes and frequency of @entity3 of massive blood transfusion. DESIGN AND SETTING: Retrospective review of the medical records of @entity0 receiving more than 10 units of blood in 24 hours at a tertiary referral hospital in 1993. @entity0 : Forty-three @entity0 fulfilled this criterion. The major reasons for massive transfusion were @entity1 (46%; 20 @entity0 ), @entity2 (21%; nine @entity0 ) and leaking @entity8 (14%; six @entity0 ). MAIN OUTCOME MEASURES: Blood products used, platelet count ( < 50 x 10(9)/L in first 48 h), @entity5 time (PT) and activated partial thromboplastin time (APTT) (twice normal in first 48 h), @entity4 , and survival. RESULTS: The 43 @entity0 used 824 units of packed cells 15.2% of the total used in 1993), 457 units of fresh frozen plasma (FFP) (17.1% of the 1993 total) and 370 units of platelets (14.8% of the 1993 total). Overall, these @entity0 consumed 16% of the total number of units of blood product used in 1993 for 1478 transfusion episodes. The overall survival rate was 60%. Severe @entity7 occurred in 19 @entity0 (44%) (mortality rate, 74%), and 13 (31%) had severe @entity6 ( < 50 x 10(9)/L). There was no significant correlation between the severity of @entity7 / @entity6 and total units transfused, or between the age of the units of blood and development of @entity7 or @entity4 . CONCLUSIONS: Severe @entity7 is common after massive transfusions. In the absence of clear correlation with the number of units transfused, "formula" replacement with plasma and platelets is unlikely to avoid the problem. Duration of tissue hypoperfusion and platelet consumption are likely to be more important than simple haemodilution of coagulation factors.

title: Massive blood transfusion in a tertiary referral hospital. Clinical outcomes and XXXX .

answer: @entity3


abstract: INTRODUCTION: Until recently, renogram, performed in @entity0 with pelvi-ureteric junction stenosis detected antenatally, has not been able to predict the probability of function improvement after surgery or the risk of function deterioration in case of conservative attitude. Recently, Schlotmann et al. have suggested that cortical transit might have this predictive role. The aim of this study, focused on those kidneys with severely impaired cortical transit, was to verify this statement. METHODS: All renograms performed in @entity0 during a 3-year period (n=729) were retrospectively reviewed and 19 pediatric @entity0 were selected based on an antenatally detected unilateral pelvi-ureteric junction syndrome, the existence of at least two renograms during the follow-up and a severe cortical transit @entity2 . Twenty-six pairs of data could be analyzed and allowed comparing preoperative and postoperative @entity1 ( @entity1 ), and the @entity1 changes during the conservative management. RESULTS: Among the 16 @entity0 who underwent pyeloplasty, 10 showed a significant @entity1 improvement. Among the 10 @entity0 with conservative follow-up, four showed a significant @entity1 . CONCLUSION: Severely impaired cortical transit seems to be a valuable marker of those @entity0 who could benefit from a pyeloplasty, either because of the high probability of postoperative @entity1 improvement, or because of @entity1 in case of an conservative approach. However, a normal cortical transit, as defined in this study, does not exclude the risk of @entity1 . Alternatively, the design of this study does not allow excluding the fact that @entity1 might improve after pyeloplasty despite a normal cortical transit.

title: Can severely impaired cortical transit predict which XXXX with pelvi-ureteric junction stenosis detected antenatally might benefit from pyeloplasty?

answer: @entity0


abstract: UNASSIGNED: Objective: The aim of this study was to evaluate the mid-term results of @entity0 with surgically treated 4th and 5th carpometacarpal (CMC) @entity3 . Methods: The study included 9 @entity4 @entity0 (9 males; mean age: 31.2 years, range: 20 to 40 years) treated with open reduction and internal fixation between 2008 and 2012. Mean follow-up period was 19.4 months. Mean interval between @entity1 and operation was 10.7 (range: 3 to 35) days. Radiological evaluation was performed at the final follow-up. Hand grip power was measured using a hand dynamometer and the injured and uninjured sides were compared. Methods: There was a statistically significant difference compared to the injured side in hand dynamometer measurements (p<0.05). Three @entity0 experienced @entity2 during heavy labor. Among these cases, 2 had delayed diagnosis and 1 a comminuted @entity4 and was unable to return to his previous job. There were no recurrent dislocations or revision surgery due to complications. Conclusion: Early diagnosis and treatment of 4th and 5th @entity4 results in good anatomical and functional results. Delayed or incorrect diagnosis of this region causes severe radiological and functional problems. Detailed physical and radiological examination can prevent @entity4 from being overlooked.

title: Fourth and fifth carpometacarpal XXXX .

answer: @entity3


abstract: PURPOSE: To examine the refractive and keratometric response of @entity3 ( @entity3 ) contact lenses for @entity4 ( @entity3 ) after a single night of contact lens wear with the goal of reducing @entity4 by +3.50 D. METHOD: Twenty @entity0 were fitted with a @entity3 HDS 100 contact lens, in one eye only. The back optic zone radius of the @entity3 lens was designed to correct 3.50 D of @entity4 . The eyes were randomly selected. The Nikon Auto Refractor was used to measure @entity2 . Corneal topography and simulated K readings were measured using the Humphrey Atlas topographer. The lens was subsequently worn overnight, and the lens was assessed the next morning on awakening. RESULTS: @entity2 changed by 1.50  0.71 D (mean    SD, range 0.50-2.75 D) immediately after lens removal in the experimental eye. Similarly, there was a change in flat K readings of 0.58  0.62 D with a range of -0.25 to +1.87 D. These results were significantly different from the baseline measurements (P<0.0001). CONCLUSIONS: The fitting of @entity3 HDS for @entity4 has a significant effect on corneal shape and @entity2 . There was a moderate yet significant steepening of the @entity1 .

title: Corneal refractive therapy gas permeable lenses for the correction of XXXX after one night of lens wear.

answer: @entity4


abstract: The aim of this cross-sectional study was to compare the role of aging in measures reflecting diurnal activity and immobility in 60 @entity1 @entity0 with predominant features of @entity3 and @entity2 and 100 healthy subjects aged 50 to 98 years. In the @entity0 , we also studied the relation between disease duration and subjective and objective measures of disease severity. Motor activity was recorded during 5 successive days at home with a wrist-worn activity monitor. For each subject, two mean measures reflecting the diurnal activity level and the relative proportion of activity and immobility were calculated. Diurnal measures of activity revealed in both groups a prominent absolute reduction of activity and an increase of the time spent without movement ("immobility") with advancing age. @entity1 @entity0 showed significantly lower values for both motor-activity measures than did the healthy subjects. The rate of the age-related decline of both diurnal activity measures in both groups, however, is comparable. Disease duration showed no relation with subjective and objective measures reflecting disease severity. This study shows that if care is taken to control for disease severity, the rate of the age-related decline of measures reflecting diurnal activity and immobility is similar in both groups. The lack of relation between disease duration and subjective and objective measures of disease severity suggests that the rate of progression of @entity1 can be reliably studied only by means of longitudinal studies.

title: @entity3 in XXXX : influence of age, disease severity, and disease duration.

answer: @entity1


abstract: The aim of this cross-sectional study was to compare the role of aging in measures reflecting diurnal activity and immobility in 60 @entity1 @entity0 with predominant features of @entity3 and @entity2 and 100 healthy subjects aged 50 to 98 years. In the @entity0 , we also studied the relation between disease duration and subjective and objective measures of disease severity. Motor activity was recorded during 5 successive days at home with a wrist-worn activity monitor. For each subject, two mean measures reflecting the diurnal activity level and the relative proportion of activity and immobility were calculated. Diurnal measures of activity revealed in both groups a prominent absolute reduction of activity and an increase of the time spent without movement ("immobility") with advancing age. @entity1 @entity0 showed significantly lower values for both motor-activity measures than did the healthy subjects. The rate of the age-related decline of both diurnal activity measures in both groups, however, is comparable. Disease duration showed no relation with subjective and objective measures reflecting disease severity. This study shows that if care is taken to control for disease severity, the rate of the age-related decline of measures reflecting diurnal activity and immobility is similar in both groups. The lack of relation between disease duration and subjective and objective measures of disease severity suggests that the rate of progression of @entity1 can be reliably studied only by means of longitudinal studies.

title: XXXX in @entity1 : influence of age, disease severity, and disease duration.

answer: @entity3


abstract: BACKGROUND: It is widely thought that widespread antibiotic use selects for community antibiotic resistance, though this has been difficult to prove in the setting of a community-randomized clinical trial. In this study, we used a randomized clinical trial design to assess whether macrolide resistance was higher in communities treated with mass @entity3 for @entity6 , compared to untreated control communities. METHODS AND FINDINGS: In a cluster-randomized trial for @entity6 control in Ethiopia, 12 communities were randomized to receive mass @entity3 treatment of @entity0 aged 1-10 years at months 0, 3, 6, and 9. Twelve control communities were randomized to receive no antibiotic treatments until the conclusion of the study. Nasopharyngeal swabs were collected from randomly selected @entity0 in the treated group at baseline and month 12, and in the control group at month 12. Antibiotic susceptibility testing was performed on @entity2 isolated from the swabs using Etest strips. In the treated group, the mean prevalence of @entity3 resistance among all monitored @entity0 increased from 3.6% (95% confidence interval [CI] 0.8%-8.9%) at baseline, to 46.9% (37.5%-57.5%) at month 12 (p = 0.003). In control communities, @entity3 resistance was 9.2% (95% CI 6.7%-13.3%) at month 12, significantly lower than the treated group (p < 0.0001). @entity1 resistance was identified in 0.8% (95% CI 0%-4.2%) of isolates in the control group at 1 year, and in no isolates in the @entity0 -treated group at baseline or 1 year. CONCLUSIONS: This cluster-randomized clinical trial demonstrated that compared to untreated control communities, nasopharyngeal pneumococcal resistance to @entity4 was significantly higher in communities randomized to intensive @entity3 treatment. Mass @entity3 distributions were given more frequently than currently recommended by the World Health Organization's @entity6 program. @entity3 use in this setting did not select for resistance to penicillins, which remain the drug of choice for @entity5 . TRIAL REGISTRATION: www.ClinicalTrials.gov NCT00322972. Please see later in the article for the Editors' Summary.

title: Antibiotic selection pressure and macrolide resistance in nasopharyngeal XXXX : a cluster-randomized clinical trial.

answer: @entity2


abstract: The circadian clock underlies daily rhythms of diverse physiological processes, and alterations in clock function have been linked to numerous pathologies. To apply chemical biology methods to modulate and dissect the clock mechanism with new chemical probes, we performed a circadian screen of    120,000 uncharacterized compounds on @entity0 cells containing a circadian reporter. The analysis identified a small molecule that potently lengthens the circadian period in a dose-dependent manner. Subsequent analysis showed that the compound also lengthened the period in a variety of cells from different tissues including the @entity1 suprachiasmatic nucleus, the central clock controlling behavioral rhythms. Based on the prominent period lengthening effect, we named the compound @entity7 . @entity7 was amenable for chemical modification to perform affinity chromatography coupled with mass spectrometry analysis to identify target proteins. Combined with siRNA-mediated gene knockdown, we identified the protein kinases @entity6  , @entity5 , and @entity4 as targets of @entity7 responsible for the observed effect on circadian period. Although individual knockdown of @entity6  , @entity5 , and @entity4 had small period effects, their combinatorial knockdown dramatically lengthened the period similar to @entity7 treatment. We characterized the role of @entity5 in the clock mechanism and found that @entity5 -mediated phosphorylation stimulated degradation of a clock protein @entity2 , similar to the function of @entity6  . @entity7 treatment inhibited @entity2 degradation, providing insight into the mechanism of @entity7 -dependent period lengthening. Using larval @entity3 , we further demonstrated that @entity7 drastically lengthened circadian period in vivo. Taken together, the chemical biology approach not only revealed @entity5 as a clock regulatory kinase but also identified a multiple kinase network conferring robustness to the clock. @entity7 provides novel possibilities in manipulating clock function due to its ability to simultaneously inhibit several key components of this conserved network across species.

title: High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals XXXX as a clock regulatory kinase.

answer: @entity5


abstract: PURPOSE: Tubulysins are natural @entity6 that inhibit tubulin polymerisation. Tubulysins are very potent inhibitors of @entity1 @entity2 cell growth, but restricted availability has limited their characterisation and development as anti- @entity2 compounds. KEMTUB10 was recently developed as a synthetic analogue of natural tubulysins. METHODS: The cell cytotoxicity of KEMTUB10 was studied in cell lines that represent the main @entity0 sub-types. The KEMTUB10 pro-apoptotic mechanism of action was studied in MCF7 and MDAMB231 cells. RESULTS: KEMTUB10 exerts a potent cytotoxic effect in cells representing the main @entity0 sub-types. KEMTUB10 blocks cells in the G2/M phase of the cell cycle and is a strong stimulator of apoptosis/cell death. KEMTUB10-induced apoptosis involves @entity4 and @entity7 , and to some extent @entity3 phosphorylation. CONCLUSIONS: KEMTUB10 is a promising new anti-mitotic that exerts a potent cytotoxic effect in @entity0 cells, blocks cells in the G2/M phase of the cell cycle and stimulates apoptosis/cell death. KEMTUB10 has a distinct mode of action to @entity5 , appears to be sensitive to different molecular factors in cells and is likely subject to different mechanisms of acquired resistance. KEMTUB10 has the potential to be an important addition to the anti- @entity2 therapeutic armoury.

title: The tubulysin analogue KEMTUB10 induces apoptosis in @entity0 cells via @entity4 , @entity7 and XXXX .

answer: @entity3


abstract: PURPOSE: Tubulysins are natural @entity6 that inhibit tubulin polymerisation. Tubulysins are very potent inhibitors of @entity1 @entity2 cell growth, but restricted availability has limited their characterisation and development as anti- @entity2 compounds. KEMTUB10 was recently developed as a synthetic analogue of natural tubulysins. METHODS: The cell cytotoxicity of KEMTUB10 was studied in cell lines that represent the main @entity0 sub-types. The KEMTUB10 pro-apoptotic mechanism of action was studied in MCF7 and MDAMB231 cells. RESULTS: KEMTUB10 exerts a potent cytotoxic effect in cells representing the main @entity0 sub-types. KEMTUB10 blocks cells in the G2/M phase of the cell cycle and is a strong stimulator of apoptosis/cell death. KEMTUB10-induced apoptosis involves @entity4 and @entity7 , and to some extent @entity3 phosphorylation. CONCLUSIONS: KEMTUB10 is a promising new anti-mitotic that exerts a potent cytotoxic effect in @entity0 cells, blocks cells in the G2/M phase of the cell cycle and stimulates apoptosis/cell death. KEMTUB10 has a distinct mode of action to @entity5 , appears to be sensitive to different molecular factors in cells and is likely subject to different mechanisms of acquired resistance. KEMTUB10 has the potential to be an important addition to the anti- @entity2 therapeutic armoury.

title: The tubulysin analogue KEMTUB10 induces apoptosis in @entity0 cells via XXXX , @entity7 and @entity3 .

answer: @entity4


abstract: PURPOSE: Tubulysins are natural @entity6 that inhibit tubulin polymerisation. Tubulysins are very potent inhibitors of @entity1 @entity2 cell growth, but restricted availability has limited their characterisation and development as anti- @entity2 compounds. KEMTUB10 was recently developed as a synthetic analogue of natural tubulysins. METHODS: The cell cytotoxicity of KEMTUB10 was studied in cell lines that represent the main @entity0 sub-types. The KEMTUB10 pro-apoptotic mechanism of action was studied in MCF7 and MDAMB231 cells. RESULTS: KEMTUB10 exerts a potent cytotoxic effect in cells representing the main @entity0 sub-types. KEMTUB10 blocks cells in the G2/M phase of the cell cycle and is a strong stimulator of apoptosis/cell death. KEMTUB10-induced apoptosis involves @entity4 and @entity7 , and to some extent @entity3 phosphorylation. CONCLUSIONS: KEMTUB10 is a promising new anti-mitotic that exerts a potent cytotoxic effect in @entity0 cells, blocks cells in the G2/M phase of the cell cycle and stimulates apoptosis/cell death. KEMTUB10 has a distinct mode of action to @entity5 , appears to be sensitive to different molecular factors in cells and is likely subject to different mechanisms of acquired resistance. KEMTUB10 has the potential to be an important addition to the anti- @entity2 therapeutic armoury.

title: The tubulysin analogue KEMTUB10 induces apoptosis in XXXX cells via @entity4 , @entity7 and @entity3 .

answer: @entity0


abstract: PURPOSE: Tubulysins are natural @entity6 that inhibit tubulin polymerisation. Tubulysins are very potent inhibitors of @entity1 @entity2 cell growth, but restricted availability has limited their characterisation and development as anti- @entity2 compounds. KEMTUB10 was recently developed as a synthetic analogue of natural tubulysins. METHODS: The cell cytotoxicity of KEMTUB10 was studied in cell lines that represent the main @entity0 sub-types. The KEMTUB10 pro-apoptotic mechanism of action was studied in MCF7 and MDAMB231 cells. RESULTS: KEMTUB10 exerts a potent cytotoxic effect in cells representing the main @entity0 sub-types. KEMTUB10 blocks cells in the G2/M phase of the cell cycle and is a strong stimulator of apoptosis/cell death. KEMTUB10-induced apoptosis involves @entity4 and @entity7 , and to some extent @entity3 phosphorylation. CONCLUSIONS: KEMTUB10 is a promising new anti-mitotic that exerts a potent cytotoxic effect in @entity0 cells, blocks cells in the G2/M phase of the cell cycle and stimulates apoptosis/cell death. KEMTUB10 has a distinct mode of action to @entity5 , appears to be sensitive to different molecular factors in cells and is likely subject to different mechanisms of acquired resistance. KEMTUB10 has the potential to be an important addition to the anti- @entity2 therapeutic armoury.

title: The tubulysin analogue KEMTUB10 induces apoptosis in @entity0 cells via @entity4 , XXXX and @entity3 .

answer: @entity7


abstract: INTRODUCTION: Standard resection for benign and borderline @entity1 of the pancreas is associated with a substantial risk of postoperative morbidity and long-term functional impairment, whereas enucleation leads to less morbidity and preserves healthy parenchyma as well as pancreatic function. The aim of this study was to evaluate the postoperative clinical outcomes and long-term functional and oncologic results after pancreatic enucleation, and to compare the clinical results of laparoscopic and open enucleation. METHODS: From March 2005 to December 2013, 65 cases of enucleation of @entity1 in the pancreas were identified through a retrospective review of medical records. RESULTS: Most of the @entity0 were @entity0 (73.8 %), and the median age was 52.7  years (interquartile range 43.1-60.9  years). Median @entity1 size was 2.5  cm (interquartile range 1.6-3.8  cm). The most common indication for enucleation was @entity5 (24, 36.9%). A clinically relevant @entity6 (International Study Group on Pancreatic Fistula grade B, C) was reported in 6 @entity0 (9.2%). The @entity0 with @entity1 of the pancreatic neck had more complications after enucleation than those with @entity1 at other locations (3/4, 75%). There were no differences of clinical outcomes between open and laparoscopic enucleation groups. At a median follow-up of 58.7  months there was one case of new-onset @entity2 , and there were no recurrences or @entity3 . CONCLUSION: Enucleation is a safe and effective procedure for the treatment of benign and borderline @entity5 . It preserves pancreatic function and is not associated with recurrence. The incidence of @entity4 , including @entity6 , is acceptable. Laparoscopic enucleation seems to be a feasible and safe approach associated with favorable perioperative outcomes for the selected @entity0 .

title: Enucleation for benign or low-grade malignant lesions of the pancreas: Single-center experience with 65 consecutive XXXX .

answer: @entity0


abstract: Regional deposition patterns determine the dose of inhaled gaseous toxicant received by various areas of the respiratory tract. To study potential species differences in upper respiratory tract (URT) deposition of @entity4 and @entity3 vapors, and to determine if deposition of these vapors could be described by a ventilation-perfusion (V-P) model, URT deposition efficiencies of these vapors were measured over a 12- to 18-min period at selected flow rates in the surgically isolated URT of @entity5 -anesthetized Fischer @entity1 and Hartley @entity2 . For both gases in both species, deposition efficiencies were significantly dependent upon inspiratory flow rate (p less than 0.0005). The V-P model predicts a linear relationship will exist between the ratio of the deposited to the nondeposited fraction and the inverse of the inspiratory flow rate. Such relationships were observed for deposition of @entity4 (r = 0.93, p less than 0.0005) and @entity3 vapors (r = 0.95, p less than 0.0005) in the @entity2 and for deposition of @entity4 vapor (r = 0.95, p less than 0.0005) in the @entity1 . In contrast, a linear relationship was not observed for @entity3 in the @entity1 suggesting that deposition mechanism(s) differ for this vapor in this species. Despite the fact that the surface area of the URT of the @entity2 is greater than that of the @entity1 , URT deposition of these vapors was as much as twice as efficient in the @entity1 as in the @entity2 (p less than 0.0005). This effect was not due to different blood:air partition coefficients as they were identical in both species. In toto, these results suggest there may be important anatomic and/or physiologic differences in the URT of the Hartley @entity2 and Fischer @entity1 . Such differences may have to be considered when comparing the response(s) of these species to toxic gases or when extrapolating data obtained from these species to the @entity0 .

title: Species differences in upper respiratory tract deposition of XXXX and @entity3 vapors.

answer: @entity4


abstract: Regional deposition patterns determine the dose of inhaled gaseous toxicant received by various areas of the respiratory tract. To study potential species differences in upper respiratory tract (URT) deposition of @entity4 and @entity3 vapors, and to determine if deposition of these vapors could be described by a ventilation-perfusion (V-P) model, URT deposition efficiencies of these vapors were measured over a 12- to 18-min period at selected flow rates in the surgically isolated URT of @entity5 -anesthetized Fischer @entity1 and Hartley @entity2 . For both gases in both species, deposition efficiencies were significantly dependent upon inspiratory flow rate (p less than 0.0005). The V-P model predicts a linear relationship will exist between the ratio of the deposited to the nondeposited fraction and the inverse of the inspiratory flow rate. Such relationships were observed for deposition of @entity4 (r = 0.93, p less than 0.0005) and @entity3 vapors (r = 0.95, p less than 0.0005) in the @entity2 and for deposition of @entity4 vapor (r = 0.95, p less than 0.0005) in the @entity1 . In contrast, a linear relationship was not observed for @entity3 in the @entity1 suggesting that deposition mechanism(s) differ for this vapor in this species. Despite the fact that the surface area of the URT of the @entity2 is greater than that of the @entity1 , URT deposition of these vapors was as much as twice as efficient in the @entity1 as in the @entity2 (p less than 0.0005). This effect was not due to different blood:air partition coefficients as they were identical in both species. In toto, these results suggest there may be important anatomic and/or physiologic differences in the URT of the Hartley @entity2 and Fischer @entity1 . Such differences may have to be considered when comparing the response(s) of these species to toxic gases or when extrapolating data obtained from these species to the @entity0 .

title: Species differences in upper respiratory tract deposition of @entity4 and XXXX vapors.

answer: @entity3


abstract: We have studied the sites of synthesis, assembly, and secretion of apoVLDL-II, a major apoprotein in very low density lipoproteins (VLDL), in the cockerel liver by immunoelectron microscopy. In the liver of the @entity0 -treated cockerel, apoVLDL-II reaction products were localized in the cisternae of the nuclear envelope and the @entity1 ( @entity1 ). Such products were not observed in the @entity2 ( @entity2 ). ApoVLDL-II reaction products were also located on the surface of lipid particles in the Golgi apparatus and secretory vesicles. Such lipid particles were not detected in the @entity1 or @entity2 . Some secretory vesicles containing the reaction products were seen during the process of fusion with the plasma membrane. Such fusion took place against the plasma membrane lining the space of Disse as well as the intercellular spaces. Reaction products also occurred in the sinusoids. These observations are compatible with the following sequence of events in the synthesis, assembly and secretion of apoproteins in VLDL in the cockerel liver: ApoVLDL-II is synthesized on bound ribosomes attached to the nuclear envelope and @entity1 , and is discharged into their cisternae. The protein is probably transported to the Golgi apparatus where the assembly of this protein and its lipid components probably takes place. Secretory vesicles derived from the Golgi apparatus carry the VLDL particles to the plasma membrane where secretion of these particles takes place by exocytosis, and the VLDL are discharged into the sinusoid via both the space of Disse and intercellular spaces.

title: Localization of apoVLDL-II, a major apoprotein in very low density lipoproteins, in the XXXX -treated cockerel liver by immunoelectron microscopy.

answer: @entity0


abstract: Orbital blowout @entity2 are relatively rare in @entity0 under 18 years of age, but may lead to serious complications. We conducted this retrospective study to evaluate @entity3 , clinical characteristics, and postoperative results in cases of orbital blowout @entity2 in the pediatric population.Eighty-three @entity0 , all less than 18 years old, with orbital blowout @entity2 , were divided into 3 groups by age: 0 to 6 years old, 7 to 12 years old, and 13 to 18 years old. The cause of injury, @entity2 locations, @entity3 grades, ocular motility restrictions, enophthalmos, and postoperative results were reviewed from their records. Chi-square tests, Fisher's exact analyses, analyses of variance, and logistic regressions were performed to determine characteristics associated with @entity3 , and to identify factors related to @entity3 in pediatric @entity0 .The most common causes of injuries were traffic accidents in the 0 to 6 years old group, normal daily activities in the 7 to 12 years old group, and assaults in the 13 to 18 years old group. Floor @entity2 were the most common location in both the 0 to 6- and 7 to 12 years old groups, and medial-floor @entity2 were the most common location in the 13 to 18 years old group. The occurrence of preoperative @entity3 was related to ocular motility restriction and enophthalmos, but not with the age group, the gender, the cause of injury, or the @entity2 locations. The time interval from injury to surgery was significant in the outcome of @entity1 (P<0.01). A statistical difference was also found in the recovery time from @entity3 among the 3 age groups (P<0.01).The characteristics of orbital blowout @entity2 varied among the different age groups. It was related to 2 factors, the cause of @entity2 locations, which probably resulted from structural growth changes and differences in daily habits. @entity0 had a slower recovery from orbital @entity2 , and the younger the @entity0 , the longer it took for recovery from @entity3 after surgery.

title: Diplopia of pediatric orbital blowout fractures: a retrospective study of 83 XXXX classified by age groups.

answer: @entity0


abstract: BACKGROUND: Repeated ghrelin administration leads to improvements in symptoms, @entity5 and exercise tolerance in cachectic @entity0 with @entity3 . We investigated the optimal ghrelin dose for underweight @entity0 with @entity4 . METHODS: In this multicenter, randomized, dose-comparison exploratory study, 44 cachectic @entity0 with @entity4 were randomly assigned pulmonary rehabilitation with intravenous twice-daily administration of 1 or 2   g/kg ghrelin for 3  weeks. The primary endpoint was improvement in 6-min walking distance (6MWD). The secondary endpoint was change in peak [Formula: see text]O2. RESULTS: Twenty-one @entity0 were assigned to the 1   g/kg ghrelin group and 23 to the 2   g/kg ghrelin group. Change from baseline 6MWD after treatment was similar between groups(1   g/kg: 53.9  m, 2   g/kg: 53.9  m, p  =  0.99). Mean change in peak [Formula: see text]O2 was significantly greater in the 2   g/kg group (63.1  ml/min) than in the 1   g/kg group (-63.8  ml/min, p  =  0.048). Food intake and lean body mass significantly increased in both groups, and the St. George Respiratory Questionnaire score, body weight, and body mass index were remarkably improved in only the 2   g/kg group, although there was no significant difference between groups. No treatment-related serious events were reported for either group. CONCLUSION: Improvements in the @entity1 uptake capacity were greater in @entity0 receiving 2   g/kg ghrelin twice daily for 3  weeks than in those receiving 1   g/kg, although exercise tolerance was similar between groups at the end of the 3-week treatment period. Thus, a twice daily dose of 2   g/kg ghrelin is recommended over 1   g/kg ghrelin for @entity0 with @entity4 and @entity2 .

title: Ghrelin Administration for XXXX : A Randomized Dose-Comparison Trial.

answer: @entity4


abstract: PURPOSE: We determined the relationship between @entity4 severity and @entity3 in a large sample of the newly diagnosed male @entity0 with @entity2 ( @entity2 ). METHODS: Data were collected from @entity0 who received polysomnography due to suspected @entity2 . The questionnaires included the Beck Depression Inventory (BDI), @entity1 ( @entity1 ), and Medical Outcomes Study (MOS)-Sleep Scale, for which Sleep Problems Index-1 (SPI-1) was calculated. The @entity2 index (AHI) and respiratory distress index (RDI) were used to measure @entity4 severity. The mediational model, which states that @entity2 severity affects @entity3 through a mediator, was tested here. RESULTS: In total, 302 male @entity0 with severe @entity2 participated. The mean @entity0 age was 48.4  years (SD  =  11.3  years). The BDI was >= 10 in 118 @entity0 (39  %) and was significantly associated with body mass index (r  =  0.114; p  =  0.048), @entity1 (r  =  0.164; p  =  0.004), SPI-1 (r  =  0.453; p  <  0.001), and RDI (r  =  0.126; p  =  0.029). According to the linear regression analyses, the RDI is not independently associated with the BDI. The strongest predictor of BDI was @entity1 (SPI-1; b  =  0.425; p  <  0.001). The bootstrap method confirmed that the depressive effects of RDI are significantly mediated by poor @entity1 (bootstrapped 95  % CI 0.0113-0.0632). CONCLUSIONS: There is evidence of a mediational role of subjective @entity1 on the relationship between @entity4 severity and @entity3 in male @entity0 with severe @entity2 .

title: The Relation Between @entity4 and XXXX in @entity0 with Severe Obstructive Sleep @entity4 : Mediational Effects of Sleep Quality.

answer: @entity3


abstract: PURPOSE: We determined the relationship between @entity4 severity and @entity3 in a large sample of the newly diagnosed male @entity0 with @entity2 ( @entity2 ). METHODS: Data were collected from @entity0 who received polysomnography due to suspected @entity2 . The questionnaires included the Beck Depression Inventory (BDI), @entity1 ( @entity1 ), and Medical Outcomes Study (MOS)-Sleep Scale, for which Sleep Problems Index-1 (SPI-1) was calculated. The @entity2 index (AHI) and respiratory distress index (RDI) were used to measure @entity4 severity. The mediational model, which states that @entity2 severity affects @entity3 through a mediator, was tested here. RESULTS: In total, 302 male @entity0 with severe @entity2 participated. The mean @entity0 age was 48.4  years (SD  =  11.3  years). The BDI was >= 10 in 118 @entity0 (39  %) and was significantly associated with body mass index (r  =  0.114; p  =  0.048), @entity1 (r  =  0.164; p  =  0.004), SPI-1 (r  =  0.453; p  <  0.001), and RDI (r  =  0.126; p  =  0.029). According to the linear regression analyses, the RDI is not independently associated with the BDI. The strongest predictor of BDI was @entity1 (SPI-1; b  =  0.425; p  <  0.001). The bootstrap method confirmed that the depressive effects of RDI are significantly mediated by poor @entity1 (bootstrapped 95  % CI 0.0113-0.0632). CONCLUSIONS: There is evidence of a mediational role of subjective @entity1 on the relationship between @entity4 severity and @entity3 in male @entity0 with severe @entity2 .

title: The Relation Between XXXX and @entity3 in @entity0 with Severe Obstructive Sleep @entity4 : Mediational Effects of Sleep Quality.

answer: @entity4


abstract: PURPOSE: We determined the relationship between @entity4 severity and @entity3 in a large sample of the newly diagnosed male @entity0 with @entity2 ( @entity2 ). METHODS: Data were collected from @entity0 who received polysomnography due to suspected @entity2 . The questionnaires included the Beck Depression Inventory (BDI), @entity1 ( @entity1 ), and Medical Outcomes Study (MOS)-Sleep Scale, for which Sleep Problems Index-1 (SPI-1) was calculated. The @entity2 index (AHI) and respiratory distress index (RDI) were used to measure @entity4 severity. The mediational model, which states that @entity2 severity affects @entity3 through a mediator, was tested here. RESULTS: In total, 302 male @entity0 with severe @entity2 participated. The mean @entity0 age was 48.4  years (SD  =  11.3  years). The BDI was >= 10 in 118 @entity0 (39  %) and was significantly associated with body mass index (r  =  0.114; p  =  0.048), @entity1 (r  =  0.164; p  =  0.004), SPI-1 (r  =  0.453; p  <  0.001), and RDI (r  =  0.126; p  =  0.029). According to the linear regression analyses, the RDI is not independently associated with the BDI. The strongest predictor of BDI was @entity1 (SPI-1; b  =  0.425; p  <  0.001). The bootstrap method confirmed that the depressive effects of RDI are significantly mediated by poor @entity1 (bootstrapped 95  % CI 0.0113-0.0632). CONCLUSIONS: There is evidence of a mediational role of subjective @entity1 on the relationship between @entity4 severity and @entity3 in male @entity0 with severe @entity2 .

title: The Relation Between @entity4 and @entity3 in @entity0 with Severe Obstructive Sleep XXXX : Mediational Effects of Sleep Quality.

answer: @entity4


abstract: PURPOSE: We determined the relationship between @entity4 severity and @entity3 in a large sample of the newly diagnosed male @entity0 with @entity2 ( @entity2 ). METHODS: Data were collected from @entity0 who received polysomnography due to suspected @entity2 . The questionnaires included the Beck Depression Inventory (BDI), @entity1 ( @entity1 ), and Medical Outcomes Study (MOS)-Sleep Scale, for which Sleep Problems Index-1 (SPI-1) was calculated. The @entity2 index (AHI) and respiratory distress index (RDI) were used to measure @entity4 severity. The mediational model, which states that @entity2 severity affects @entity3 through a mediator, was tested here. RESULTS: In total, 302 male @entity0 with severe @entity2 participated. The mean @entity0 age was 48.4  years (SD  =  11.3  years). The BDI was >= 10 in 118 @entity0 (39  %) and was significantly associated with body mass index (r  =  0.114; p  =  0.048), @entity1 (r  =  0.164; p  =  0.004), SPI-1 (r  =  0.453; p  <  0.001), and RDI (r  =  0.126; p  =  0.029). According to the linear regression analyses, the RDI is not independently associated with the BDI. The strongest predictor of BDI was @entity1 (SPI-1; b  =  0.425; p  <  0.001). The bootstrap method confirmed that the depressive effects of RDI are significantly mediated by poor @entity1 (bootstrapped 95  % CI 0.0113-0.0632). CONCLUSIONS: There is evidence of a mediational role of subjective @entity1 on the relationship between @entity4 severity and @entity3 in male @entity0 with severe @entity2 .

title: The Relation Between @entity4 and @entity3 in XXXX with Severe Obstructive Sleep @entity4 : Mediational Effects of Sleep Quality.

answer: @entity0


abstract: The injection of bile under low pressure led in 21 @entity3 out of 30 to a process of acute @entity4 and to the reproduction of the different histopathological types of @entity4 seen in @entity0 . This represents a weighty argument in favour of the concept of @entity4 , @entity4 with sometimes major cytosteatonecrosis and necrosing @entity4 as different manifestations of the same disease, which is not universally accepted. Our research has once again emphasized the fact that the interstitial phenomena and in @entity2 precede @entity2 . Morphological studies were used to attempt to define the link between fat @entity2 and acinar @entity2 . Light microscopy showed that there was no topographic evidence of direct involvement of the acinar cell in contact with fat @entity2 . By contrast, ultrastructural studies revealed initial involvement of the basal pole of the acinar cell. This would emphasize the responsibility of interstitial phenomena in the maintenance, if not the induction, of acinar @entity2 . It cannot be excluded that fat @entity2 could indirectly, via the liberation of factors carried by @entity1 , play a role in these phenomena of acinar @entity2 . In addition, it was noted that the apical poles of the acinar cells did not seem to be damaged, the acinar lumina were dilated and there was loss of the intercellular junctions. This would hence indicate the possible passage into the interstitium of a toxic substance ( @entity5 , enzymes liberated in excess) coming directly from the acinar lumina.

title: [Experimental XXXX of ductal origin. Anatomo-pathologic and ultrastructural study].

answer: @entity4


abstract: BACKGROUND: @entity4 has been the only available antiplatelet drug used along with aspirin in @entity0 of ACS. In recent years 2 new antiplatelet drugs ( @entity5 and Ticagrelor) have become available. @entity5 in the dose of 10  mg @entity6 has been found to be more efficacious but with increased risk of major @entity2 . For this reason it has not gained widespread usage in ACS @entity0 undergoing PCI. There are no systematic data on the use of @entity5 in Indian population. METHOD: This is a prospective, multicentric, hospital registry of 1000 @entity0 with ACS undergoing PCI who were administered @entity5 . The primary safety endpoint of this study was major and minor @entity2 while the efficacy endpoint is the composite of CV death, nonfatal MI, @entity1 up to 30 days after PCI. @entity0 with high @entity2 risk were excluded. RESULTS: Most @entity0 (91%) received loading dose of @entity5 along with the maintenance dose getting according to the defined protocol. @entity0 were followed up to 30 days post procedure. Primary efficacy end point was reached in 3 @entity0 only with two of them dying due to possible stent @entity3 and the third requiring revascularization of the target vessel for stent @entity3 . One major and 19 minor @entity2 complications were recorded, with access site @entity2 in 0.7% _ non-access site @entity2 in 1.2% of the subjects. CONCLUSION: @entity5 was found to be effective _ not associated with a high incidence of @entity2 in the high risk ACS @entity0 when those at a high @entity2 risk were excluded.

title: Safety of XXXX in Indian @entity0 - Multicentric registry of 1000 cases.

answer: @entity5


abstract: BACKGROUND: @entity4 has been the only available antiplatelet drug used along with aspirin in @entity0 of ACS. In recent years 2 new antiplatelet drugs ( @entity5 and Ticagrelor) have become available. @entity5 in the dose of 10  mg @entity6 has been found to be more efficacious but with increased risk of major @entity2 . For this reason it has not gained widespread usage in ACS @entity0 undergoing PCI. There are no systematic data on the use of @entity5 in Indian population. METHOD: This is a prospective, multicentric, hospital registry of 1000 @entity0 with ACS undergoing PCI who were administered @entity5 . The primary safety endpoint of this study was major and minor @entity2 while the efficacy endpoint is the composite of CV death, nonfatal MI, @entity1 up to 30 days after PCI. @entity0 with high @entity2 risk were excluded. RESULTS: Most @entity0 (91%) received loading dose of @entity5 along with the maintenance dose getting according to the defined protocol. @entity0 were followed up to 30 days post procedure. Primary efficacy end point was reached in 3 @entity0 only with two of them dying due to possible stent @entity3 and the third requiring revascularization of the target vessel for stent @entity3 . One major and 19 minor @entity2 complications were recorded, with access site @entity2 in 0.7% _ non-access site @entity2 in 1.2% of the subjects. CONCLUSION: @entity5 was found to be effective _ not associated with a high incidence of @entity2 in the high risk ACS @entity0 when those at a high @entity2 risk were excluded.

title: Safety of @entity5 in Indian XXXX - Multicentric registry of 1000 cases.

answer: @entity0


abstract: UNASSIGNED: OBJECTIVE To detect the pathogenic mutation in a @entity0 with @entity2 using IonTorrent Personal Genome Machine (PGM) and assess the feasibility of such technology for analyzing complex monogenic diseases. METHODS Peripheral blood sample was collected from the @entity0 . Genomic DNA was isolated using a standard method and subjected to targeted sequencing using an Ion Ampliseq Inherited Disease Panel. DNA fragment was ligated with a barcoded sequencing adaptor. Template preparation, emulsion PCR, and Ion Sphere Particles enrichment were carried out using the Ion One Touch system. Data from the PGM runs were processed using Ion Torrent Suite 3.2 software to generate sequence reads. All variants were filtered against dbSNPl37. DNA sequences were visualized with an Integrated Genomics Viewer. RESULTS After data analysis and database filtering, a previously reported nonsense mutation, @entity4 ( @entity5 ), and a novel mutation @entity6 ( @entity7 ) were identified in the @entity3 gene in this @entity0 . Both mutations were verified by conventional Sanger sequencing. Conclusion Pathogenic @entity3 mutations have been identified in a @entity0 with @entity2 . This new-generation targeted sequencing on the PGM sequencers can be applied for genetic diagnosis of @entity1 .

title: [Detection of pathogenic mutations for XXXX using new-generation semiconductor targeted sequencing.]

answer: @entity2


abstract: UNASSIGNED: @entity0 ( @entity1 ), is a potent neurotoxin targeting sodium channels that has been identified in multiple marine and terrestrial organisms. It was recently detected in the Opisthobranch Pleurobranchaea maculata and a Platyhelminthes Stylochoplana sp. from New Zealand. Knowledge on the distribution of @entity1 within these organisms is important to assist in elucidating the origin and ecological role of this toxin. Intracellular micro-distribution of @entity1 was investigated using a monoclonal antibody-based immunoenzymatic technique. @entity0 was strongly localized in neutral mucin cells and the basement membrane of the mantle, the oocytes and follicles of the gonad tissue, and in the digestive tissue of P. maculata. The ova and pharynx were the only two structures to contain @entity1 in Stylochoplana sp. Using liquid chromatography-mass spectrometry, @entity1 was identified in the larvae and eggs, but not the gelatinous egg cases of P. maculata. @entity0 was present in egg masses of Stylochoplana sp. These data suggest that @entity1 has a defensive function in adult P. maculata, who then invest this in their progeny for protection. Localization in the digestive tissue of P. maculata potentially indicates a dietary source of @entity1 . Stylochoplana sp. may use @entity1 in prey capture and for the protection of offspring.

title: Intracellular Immunohistochemical Detection of XXXX in Pleurobranchaea maculata (Gastropoda) and Stylochoplana sp. (Turbellaria).

answer: @entity0


abstract: We have evaluated the use of Gallium-67 scans as an aid to the diagnosis of @entity3 around the hip joint after operation. We performed 12 @entity5 -67 scintiscans on six @entity0 with diaphyseal @entity2 of the femur or @entity4 reduced by external fixation, and 65 scintiscans on 60 hips after operation, which included 22 Moore's prosthesis, 31 total replacements, three nail-plates and four revisions of total replacements. We also scanned the @entity6 in a further 11 @entity0 . Simple @entity2 or osteotomies did not lead to abnormal uptake of 67Ga. Although some uptake in the scar was encountered the surgical wound did not complicate the interpretation of the scan. When assessing @entity3 in the hip operations the rate of true-positive was 11/11, or 100%. The false-positive rate could not be assessed until after at least one year's follow-up. It was certainly less than 14% immediately after operation and less than 6% when the scan was performed three months after operation. Four @entity0 were found to have a loose prosthesis but had a normal scintiscan, as had three @entity0 presenting with post-operative @entity1 . It appears that 67Ga is clinically an efficient means for early detection of @entity3 about the operated hip, and is useful in the differential diagnosis of a @entity1 hip after surgery.

title: Gallium-67 citrate as an aid to the diagnosis of XXXX in hip surgery.

answer: @entity3


abstract: UNASSIGNED: In @entity2 , cytogenetic changes display important value for @entity0 ' outcome. In this setting, the most important changes are the del(17p), and the t(4;14), conferring a poor outcome. However, a certain heterogeneity is observed in survival of these high-risk @entity0 . We hypothesized that other chromosomal changes may impact the outcome. We retrospectively analyzed a large series of 242 @entity0 displaying either the t(4;14) (157 @entity0 ), or the del(17p) (110 @entity0 ), 25 @entity0 presenting @entity1 , using SNP-array. In @entity0 with t(4;14), del(1p32) (p<0.001), del22q (p<0.05) and more than 30 chromosomal structural changes (p=0.01) negatively impacted PFS. For OS, @entity4 ) (p=0.01), del(1p32) (p<0.001), and the number of chromosomal structural changes (p<0.05 and p=0.01 for [10;30[and more than 30 structural changes, respectively) worsened the prognosis of @entity0 . For @entity0 with del(17p), del6q (p=0.01) worsened the prognosis of @entity0 , whereas @entity3 (p=0.01) and monosomy 14 (p=0.03) were found to have a protective effect on PFS. For OS, del(1p32) (p=0.01) worsened the prognosis of @entity0 , whereas more than 8 numerical changes (p=0.004) was found to have a protective effect on survival. This study, which is the largest series of high-risk @entity0 , analyzed with the most modern genomic technique, identified one main factor negatively impacting survival: del(1p32).

title: Role of additional chromosomal changes in the prognostic value of t(4;14) and del(17p) in XXXX : the IFM experience.

answer: @entity2


abstract: In @entity0 with @entity3 , left ventricular performance during stress is affected by the degree of @entity7 . In order to verify whether there exists a relationship between the extent of wall motion abnormalities detectable during @entity6 and the degree of @entity2 , 76 @entity0 , without previous @entity4 , were studied. Each @entity0 underwent cross-sectional echocardiography during transesophageal @entity6 and exercise electrocardiography before coronary angiography. Of the 76 @entity0 , 46 had significant @entity3 ( @entity5 greater than or equal to 75% of at least one major coronary vessel), while 30 had normal coronaries or a @entity5 of less than 75%. Eighteen @entity0 had single-, 14 had two- and 14 had @entity1 . For each @entity0 a coronary score was obtained: the score used took into consideration the site, number and severity of the @entity5 . This score was then correlated with the wall motion score, obtained from the analysis of 9 segments of the left ventricle. A weak correlation was obtained between wall motion score at rest and coronary score (r = -0.42), while the correlation between coronary score and the difference between wall motion score at rest and during transesophageal @entity6 was slightly better (r = 0.53); this correlation further improved if wall motion score during pacing was considered (r = -0.63). If the @entity0 with discordant diagnostic tests (echocardiography during transesophageal @entity6 and exercise electrocardiography) were excluded, the correlation coefficient between coronary score and wall motion score during pacing increased even more (r = -0.77). IN CONCLUSION: (1) analysis of wall motion of the left ventricle during @entity6 is useful for the non-invasive evaluation of the severity of @entity2 ; (2) cross-sectional echocardiography during @entity6 , apart from being a useful diagnostic tool, is also a help in judging the degree of severity of @entity3 .

title: Prediction of the extent of @entity3 with the evaluation of left ventricular wall motion abnormalities during XXXX . A cross-sectional echocardiographic study.

answer: @entity6


abstract: In @entity0 with @entity3 , left ventricular performance during stress is affected by the degree of @entity7 . In order to verify whether there exists a relationship between the extent of wall motion abnormalities detectable during @entity6 and the degree of @entity2 , 76 @entity0 , without previous @entity4 , were studied. Each @entity0 underwent cross-sectional echocardiography during transesophageal @entity6 and exercise electrocardiography before coronary angiography. Of the 76 @entity0 , 46 had significant @entity3 ( @entity5 greater than or equal to 75% of at least one major coronary vessel), while 30 had normal coronaries or a @entity5 of less than 75%. Eighteen @entity0 had single-, 14 had two- and 14 had @entity1 . For each @entity0 a coronary score was obtained: the score used took into consideration the site, number and severity of the @entity5 . This score was then correlated with the wall motion score, obtained from the analysis of 9 segments of the left ventricle. A weak correlation was obtained between wall motion score at rest and coronary score (r = -0.42), while the correlation between coronary score and the difference between wall motion score at rest and during transesophageal @entity6 was slightly better (r = 0.53); this correlation further improved if wall motion score during pacing was considered (r = -0.63). If the @entity0 with discordant diagnostic tests (echocardiography during transesophageal @entity6 and exercise electrocardiography) were excluded, the correlation coefficient between coronary score and wall motion score during pacing increased even more (r = -0.77). IN CONCLUSION: (1) analysis of wall motion of the left ventricle during @entity6 is useful for the non-invasive evaluation of the severity of @entity2 ; (2) cross-sectional echocardiography during @entity6 , apart from being a useful diagnostic tool, is also a help in judging the degree of severity of @entity3 .

title: Prediction of the extent of XXXX with the evaluation of left ventricular wall motion abnormalities during @entity6 . A cross-sectional echocardiographic study.

answer: @entity3


abstract: IMPORTANCE: @entity8 media is characterized as an ongoing @entity2 with accumulation of an effusion in the middle ear cleft. The molecular mechanisms underlying the pathogenesis, particularly the inflammatory response, remain largely unknown. We hypothesize that aspiration of gastric contents into the nasopharynx may be responsible for the initiation of the inflammatory process or aggravate a preexisting condition. OBJECTIVE: To investigate the correlation of gastric @entity10 with inflammatory cytokines, @entity9 , and clinical outcomes. DESIGN, SETTING, AND @entity0 : Prospective study of 129 pediatric @entity0 undergoing myringotomy with tube placement for @entity8 media at a tertiary care pediatric hospital. MAIN OUTCOMES AND MEASURES: Ear samples were tested for @entity10 ; cytokines @entity5 , @entity6 , and @entity1 @entity3 factor; and bacterial culture inoculation. Data were analyzed by descriptive statistics and regression analysis to identify risk factors for the presence of @entity10 and to correlate @entity10 levels with cytokine levels, @entity4 status, and clinical outcomes. RESULTS: Of the 129 @entity0 , 199 ear samples were obtained; 82 samples (41%) and 64 @entity0 (50%) were positive for @entity10 as measured by immunoassay. @entity10 positivity correlated with age younger than 3.0 years (mean [SD], 2.3 [2.1] years in the positive group vs 3.3 [3.0] years in the negative group) and with all 3 cytokine levels (mean [SD] @entity1 @entity3 factor, 29.5 [45.9] pg/mL in the positive group vs 13.2 [21.6] pg/mL in the negative group; @entity5 , 6791.7 [9389.1] pg/mL in the positive group vs 2849.9 [4066.3] pg/mL in the negative group; and @entity6 , 6828.2 [8122.3] pg/mL in the positive group vs 2925.1 [3364.5] pg/mL in the negative group [all P   <   .05]); however, logistic regression analysis showed that only @entity6 (odds ratio, 3.96; 95% CI, 1.3-12.0; P   =   .02) and age (odds ratio, 3.83; 95% CI, 1.2-12.7; P   =   .03) were significant independent variables. No statistically significant association was found with other parameters. Multiple linear regressions revealed that the levels of @entity10 were correlated with @entity6 levels (R2   =   0.248; P   <   .001) and the need for second or third tubes 6 to 12 months after the first (R2   =   0.102; P   =   .006). The presence of @entity10 in the middle ear was not associated with increased @entity9 . @entity6 was independent and significantly associated with both @entity10 levels and @entity9 (R2   =   0.144 and 0.263, respectively; P   =   .001 for both). CONCLUSIONS AND RELEVANCE: Extraesophageal reflux as indicated by the presence of @entity10 is closely involved in the middle ear inflammatory process and may worsen the disease in some @entity0 ; however, a proof of cause and effect between extraesophageal reflux and @entity7 requires further investigation.

title: The role of gastric pepsin in the inflammatory cascade of XXXX .

answer: @entity7


abstract: IMPORTANCE: The etiology and optimal treatment are unknown for @entity4 , an aggressive @entity1 that affects vascular endothelial cells and can be mistaken for benign lesions such as @entity3 . OBJECTIVE: To determine the treatment outcomes of @entity0 with @entity4 of the face or scalp treated with a combination of surgery, radiation therapy, and/or chemotherapy. DESIGN, SETTING, AND @entity0 : Retrospective study of 55 @entity0 with @entity4 of the face or scalp treated between January 1, 1973, and December 31, 2012, at a tertiary-care academic medical institution. INTERVENTIONS: Surgery, radiation therapy, and/or chemotherapy. MAIN OUTCOMES AND MEASURES: Locoregional control (LRC), @entity2 ( @entity2 ), and @entity2 ( @entity2 ). RESULTS: Fifty-five @entity0 had @entity4 localized to the face or scalp. Forty of these @entity0 (73%) received a combination of surgery, radiation therapy, and/or chemotherapy. Eight @entity0 (15%) were treated with surgery alone, 1 (2%) with radiation alone, 5 (9%) with chemotherapy alone, and 1 (2%) with observation alone. Median (range) follow-up for surviving @entity0 was 25.2 (4.7-227.1) months. Five-year LRC, @entity2 , and @entity2 (95% CI) were 18% (7%-32%), 16% (6%-31%), and 38% (21%-54%), respectively. Of 36 @entity0 with failed treatment, 34 had failure in a local and/or regional site. On univariate analysis, the use of multimodality therapy (vs no multimodality therapy) was associated with higher 5-year LRC (95% CI) (20% [3%-37%] vs 11% [0%-29%]; P   =   .04), higher @entity2 (19% [2%-36%] vs 10% [0%-27%]; P   =   .02), and higher @entity2 (46% [26%-66%] vs 16% [0%-43%]; P   =   .04). Age 70 years or older (vs <70 years) was associated with lower 5-year LRC (95% CI) (5% [0%-14%] vs 48% [23%-74%]; P   =   .02) and lower @entity2 (5% [0%-13%] vs 49% [24%-75%]; P   =   .04). Radiation therapy (vs no radiation therapy) was associated with higher 5-year LRC (95% CI) (20% [3%-36%] vs 12% [0%-32%]; P   =   .02) and higher @entity2 (19% [2%-35%] vs 12% [0%-31%]; P   =   .004). On multivariable analysis, age younger than 70 years (vs >= 70 years) was associated with improved 5-year LRC (95% CI) (48% [23%-74%] vs 5% [0%-14%]; P   =   .03) and @entity2 (49% [24%-75%] vs 49% [24%-75%]; P   =   .04). CONCLUSIONS AND RELEVANCE: Multimodality therapy for @entity4 is associated with improved LRC, @entity2 , and @entity2 . Younger @entity0 with resectable disease undergoing multimodality therapy for @entity4 had the best clinical outcomes.

title: XXXX of the scalp and face: the Mayo Clinic experience.

answer: @entity4


abstract: Yaws, caused by @entity6 ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of @entity4 is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of @entity4 at a lower target dose was previously undertaken in two regions of Ghana for the control of @entity5 . Ongoing reporting of yaws raises the possibility that resistance may have emerged in @entity6 pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for @entity5 had previously been conducted. @entity0 aged 5-17 years with @entity2 compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all @entity0 . 90 @entity0 with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for @entity6 ssp pertenue was negative in all @entity0 , but @entity7 DNA was detected in 9 lesions. In these communities, previously treated for @entity5 , we found no evidence of ongoing transmission of yaws. @entity7 was associated with a proportion of @entity1 , but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post- @entity3 surveillance systems is required to better inform yaws control programmes.

title: A cross-sectional study of 'yaws' in districts of ghana which have previously undertaken @entity4 mass drug administration for XXXX control.

answer: @entity5


abstract: Yaws, caused by @entity6 ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of @entity4 is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of @entity4 at a lower target dose was previously undertaken in two regions of Ghana for the control of @entity5 . Ongoing reporting of yaws raises the possibility that resistance may have emerged in @entity6 pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for @entity5 had previously been conducted. @entity0 aged 5-17 years with @entity2 compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all @entity0 . 90 @entity0 with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for @entity6 ssp pertenue was negative in all @entity0 , but @entity7 DNA was detected in 9 lesions. In these communities, previously treated for @entity5 , we found no evidence of ongoing transmission of yaws. @entity7 was associated with a proportion of @entity1 , but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post- @entity3 surveillance systems is required to better inform yaws control programmes.

title: A cross-sectional study of 'yaws' in districts of ghana which have previously undertaken XXXX mass drug administration for @entity5 control.

answer: @entity4


abstract: BACKGROUND: The purpose of this study was to evaluate the diagnostic accuracy of @entity3 (FDG) positron emission tomography-computed tomography (PET-CT) for @entity4 ( @entity4 ) staging of @entity2 @entity0 undergoing radical cystectomy (RC) with extended pelvic lymphadenectomy compared to conventional CT. METHODS: A total of 61 @entity0 underwent FDG PET-CT before RC and extended pelvic lymphadenectomy. A template for extended pelvic lymphadenectomy to the level of the inferior mesenteric artery was divided into 11 anatomic nodal packets. Definitive pathologic findings of resected LNs were correlated with the results of FDG PET-CT and CT alone in a @entity0 - and nodal packet-based manner. RESULTS: Among the 61 @entity0 , pathological staging confirmed @entity4 @entity1 in 17 @entity0 (27.9  %). In total, 627 @entity4 packets (2580 LNs) were resected and histologically evaluated. The mean number of LNs removed was 42 (median 40; range 22-118). Of the 627 @entity4 packets removed, 27 packets (4.3  %) were positive for @entity4 @entity1 based on pathologic analysis. On a @entity0 -based analysis, FDG PET-CT and conventional CT showed a sensitivity of 47.1 and 29.4  %, respectively, specificity of 93.2 and 97.7  %, respectively, positive predictive value ( @entity5 ) of 72.7 and 78.2  %, respectively, and negative predictive value (NPV) of 82.0 and 78.2  %, respectively. On a nodal packet-based analysis, sensitivity, specificity, @entity5 , and NPV were 14.8, 97.8, 23.5, and 96.2  %, respectively, for PET-CT and 11.1, 98.7, 27.3, and 96.1  %, respectively, for conventional CT. CONCLUSIONS: Combined FDG PET-CT did not improve the diagnostic accuracy of conventional CT for the detection of @entity4 @entity1 in @entity2 @entity0 scheduled for RC.

title: FDG PET-CT for Lymph Node Staging of XXXX : A Prospective Study of @entity0 with Extended Pelvic Lymphadenectomy.

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to evaluate the diagnostic accuracy of @entity3 (FDG) positron emission tomography-computed tomography (PET-CT) for @entity4 ( @entity4 ) staging of @entity2 @entity0 undergoing radical cystectomy (RC) with extended pelvic lymphadenectomy compared to conventional CT. METHODS: A total of 61 @entity0 underwent FDG PET-CT before RC and extended pelvic lymphadenectomy. A template for extended pelvic lymphadenectomy to the level of the inferior mesenteric artery was divided into 11 anatomic nodal packets. Definitive pathologic findings of resected LNs were correlated with the results of FDG PET-CT and CT alone in a @entity0 - and nodal packet-based manner. RESULTS: Among the 61 @entity0 , pathological staging confirmed @entity4 @entity1 in 17 @entity0 (27.9  %). In total, 627 @entity4 packets (2580 LNs) were resected and histologically evaluated. The mean number of LNs removed was 42 (median 40; range 22-118). Of the 627 @entity4 packets removed, 27 packets (4.3  %) were positive for @entity4 @entity1 based on pathologic analysis. On a @entity0 -based analysis, FDG PET-CT and conventional CT showed a sensitivity of 47.1 and 29.4  %, respectively, specificity of 93.2 and 97.7  %, respectively, positive predictive value ( @entity5 ) of 72.7 and 78.2  %, respectively, and negative predictive value (NPV) of 82.0 and 78.2  %, respectively. On a nodal packet-based analysis, sensitivity, specificity, @entity5 , and NPV were 14.8, 97.8, 23.5, and 96.2  %, respectively, for PET-CT and 11.1, 98.7, 27.3, and 96.1  %, respectively, for conventional CT. CONCLUSIONS: Combined FDG PET-CT did not improve the diagnostic accuracy of conventional CT for the detection of @entity4 @entity1 in @entity2 @entity0 scheduled for RC.

title: FDG PET-CT for Lymph Node Staging of @entity2 : A Prospective Study of XXXX with Extended Pelvic Lymphadenectomy.

answer: @entity0


abstract: PURPOSE: To evaluate demographics, characteristics, and outcomes of @entity2 (OGIs) in @entity1 (MVAs). METHODS: Retrospective chart review of @entity0 with OGIs related to MVAs that presented to University Hospital, Newark, from 2000 to 2012. RESULTS: Twenty-five @entity0 were identified; the average age of the @entity0 was 33.3 years old (range, 5-75). The majority of @entity0 (64 %) were males. The 25 vehicles comprised 24 automobiles and one motorcycle. Ten @entity0 (40 %) wore seatbelts, and five (20 %) did not wear seatbelts. The seatbelt status was not documented in the remaining cases. Ethanol was documented as a contributing factor in five of the accidents. In terms of open-globe classification, 15 OGIs (60 %) were ruptures, and five (20 %) were penetrating injuries; three (12 %) had intraocular foreign bodies. Ten eyes (40 %) had a final VA of 20/400 or worse. Fourteen eyes (56 %) achieved a final VA of 20/200 or better; seven eyes (28 %) achieved a final VA of 20/40 or better. CONCLUSION: Fifty-six percent of eyes with an open-globe injury related to MVAs achieved a final VA of 20/200 or better in this series. No eyes developed endophthalmitis.

title: XXXX with @entity1 : a 12-year review.

answer: @entity2


abstract: PURPOSE: To evaluate demographics, characteristics, and outcomes of @entity2 (OGIs) in @entity1 (MVAs). METHODS: Retrospective chart review of @entity0 with OGIs related to MVAs that presented to University Hospital, Newark, from 2000 to 2012. RESULTS: Twenty-five @entity0 were identified; the average age of the @entity0 was 33.3 years old (range, 5-75). The majority of @entity0 (64 %) were males. The 25 vehicles comprised 24 automobiles and one motorcycle. Ten @entity0 (40 %) wore seatbelts, and five (20 %) did not wear seatbelts. The seatbelt status was not documented in the remaining cases. Ethanol was documented as a contributing factor in five of the accidents. In terms of open-globe classification, 15 OGIs (60 %) were ruptures, and five (20 %) were penetrating injuries; three (12 %) had intraocular foreign bodies. Ten eyes (40 %) had a final VA of 20/400 or worse. Fourteen eyes (56 %) achieved a final VA of 20/200 or better; seven eyes (28 %) achieved a final VA of 20/40 or better. CONCLUSION: Fifty-six percent of eyes with an open-globe injury related to MVAs achieved a final VA of 20/200 or better in this series. No eyes developed endophthalmitis.

title: @entity2 with XXXX : a 12-year review.

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Wave reflections and arterial stiffness are independent cardiovascular risk factors in @entity3 . Previous studies in this population included only static recordings before and after dialysis. This study investigated the variation of these indices during intra- and interdialytic intervals and examined demographic, clinical, and hemodynamic variables related to arterial function in @entity0 undergoing hemodialysis. DESIGN, SETTING, @entity0 , _ MEASUREMENTS: Between February 2013 and May 2014, a total of 153 @entity0 receiving maintenance hemodialysis in five dialysis centers of northern Greece underwent ambulatory BP monitoring with the newly introduced Mobil-O-Graph device (IEM, Stolberg, Germany) over a midweek dialysis session and the subsequent interdialytic period. Mobil-O-Graph is an oscillometric device that records brachial BP and pulse waves and estimates, via generalized transfer function, aortic BP, augmentation index (AIx) as a measure of wave reflections, and pulse wave velocity ( @entity2 ) as an index of arterial stiffness. RESULTS: AIx was lower during dialysis than in the interdialytic period of dialysis-on day (Day 1) (mean  SD, 24.7%  9.7% versus 26.8%  9.4%; P<0.001). In contrast, @entity2 remained unchanged between these intervals (9.31  2.2 versus 9.29  2.3 m/sec; P=0.60). Both AIx and @entity2 increased during dialysis-off day (Day 2) versus the out-of-dialysis period of Day 1 (28.8%  9.8% versus 26.8%  9.4% [P<0.001] and 9.39  2.3 versus 9.29  2.3 m/sec [P<0.001]). Older age (odds ratio [OR], 1.09; 95% confidence interval [95% CI], 1.02 to 1.15), female sex (OR, 7.56; 95% CI, 1.64 to 34.81), @entity1 status (OR, 8.84; 95% CI, 1.76 to 17.48), and higher mean BP (OR, 1.17; 95% CI, 1.09 to 1.27) were associated with higher odds of high AIx; higher heart rate was associated with lower odds (OR, 0.71; 95% CI, 0.63 to 0.80) of high AIx. Older age (OR, 2.04; 95% CI, 1.61 to 2.58) and higher mean BP (OR, 1.15; 95% CI, 1.05 to 1.27) were independent correlates of high @entity2 . CONCLUSIONS: This study showed a gradual interdialytic increase in AIx, whereas @entity2 was only slightly elevated during Day 2. Future studies are needed to elucidate the value of these ambulatory measures for cardiovascular risk prediction in @entity3 .

title: Ambulatory recording of wave reflections and arterial stiffness during intra- and interdialytic periods in XXXX treated with dialysis.

answer: @entity0


abstract: Vena caval extension of @entity6 occurs in 4 to 10 per cent of the @entity0 and usually is considered a poor prognostic sign. To ascertain the true effect of vena caval extension on survival a retrospective analysis was done of 27 @entity0 who had undergone radical nephrectomy and removal of vena caval thrombus between 1970 and 1980. An additional 46 cases were collected from series in the literature and composite statistics were compiled. Extension to the vena cava alone had a limited impact on prognosis (survival for 2 years--81 per cent, 5 years--53 per cent, median--81 months). Capsular invasion negatively influenced survival (2-year survival 66 per cent). Disease in the regional lymph nodes had a much greater impact on survival, with a 2-year survival rate of 35 per cent and no @entity0 survived 5 years (median survival 24 months). Only 5 per cent of the @entity0 with distant @entity1 survived 2 years and none survived 5 years (median survival 8.5 months). In conclusion, the prognosis of @entity0 with vena caval @entity2 thrombus is influenced primarily by known adverse prognostic factors: capsular invasion, @entity3 and distant @entity1 . Aggressive surgery in @entity0 with gross nodal involvement or distant @entity1 is unwarranted since it contributes nothing to survival and only 7 per cent of the @entity0 had significant signs or symptoms secondary to the vena caval thrombus itself. @entity0 with vena caval extension alone have a cure rate approaching that of @entity0 with stage I @entity4 following radical @entity5 .

title: Prognostic implications of vena caval extension of XXXX .

answer: @entity6


abstract: BACKGROUND: The aim of our multicenter study was to assess the clinical outcome and safety of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in @entity1 with @entity0 ( @entity2 ). METHODS: From May 2011 to February 2013, 42 @entity1 with 51 @entity2 in one or both breasts were selected for treatment with US-guided HIFU. Eight of 51 @entity2 were treated twice. @entity1 ' age ranged from 16 to 52  years (mean 32  years). All @entity1 with @entity2 underwent core needle biopsy with histological confirmation. HIFU treatment was performed as an outpatient procedure under conscious sedation. Exclusion criteria were pregnant or lactating @entity1 , microcalcifications within the lesion at mammogram, history of @entity0 , previous laser or radiation therapy, and breast implant in the same breast. All @entity1 signed written informed consent. After the treatment, follow-up US with volume evaluation was performed at 2, 6, and 12  months. RESULTS: The @entity2 mean baseline volume was 3.89  ml (0.34-19.66  ml). At 2-month follow-up, the mean volume reduction was 33.2%        19.1% and achieved significance at 6-month (59.2%        18.2%, p   <   0.001) and 12-month (72.5%        16.7%, p   <   0.001) follow-up. Related side effects as superficial skin burn with @entity4 -like aspect in three @entity1 and @entity3 over the treated area in one @entity1 were transient and resolved spontaneously. In one @entity1 , asymptomatic subcutaneous induration persisted at the end of the study. CONCLUSIONS: US-guided HIFU treatment is an effective noninvasive method for the treatment of breast @entity2 and well tolerated by the @entity1 . Preliminary results are encouraging and show that HIFU could be an alternative to surgery for breast @entity2 .

title: Ultrasound-guided high-intensity focused ultrasound treatment of XXXX -a multicenter experience.

answer: @entity0


abstract: UNASSIGNED: OBJECT Multiple trials have shown improved survival and functional outcome in @entity0 treated with decompressive craniectomy (DC) for @entity1 following @entity2 . It has been assumed that decompression induces an improvement in cerebral perfusion. This observational study directly measured cerebral perfusion before and after decompression. METHODS Sixteen @entity0 were prospectively examined with perfusion CT within 6 hours prior to surgery and 12 hours after surgery. Preoperative and postoperative perfusion measurements were compared and correlated. RESULTS Following DC there was a significant increase in cerebral blood flow in all measured territories and additionally an increase in cerebral blood volume in the penumbra (p = 0.03). These changes spread as far as the contralateral hemisphere. No significant changes in mean transit time or Tmax (time-to-peak residue function) were observed. CONCLUSIONS The presurgical perfusion abnormalities likely reflected local pressure-induced hypoperfusion with impaired autoregulation. The improvement in perfusion after decompression implied an increase in perfusion pressure, likely linked to partial restoration of autoregulation. The increase in perfusion that was observed might partially be responsible for improved clinical outcome following decompressive surgery for @entity2 . The predictive value of perfusion CT on outcome needs to be evaluated in larger trials.

title: The influence of decompressive craniectomy for XXXX on early cerebral perfusion.

answer: @entity2


abstract: Bone morphogenetic proteins (BMPs), members of the transforming growth factor b (TGFb) superfamily, play important roles in folliculogenesis in various species; however, little is known about their role in luteal function. In this study, we investigated the expression, regulation, and effects of @entity3 , @entity9 , and @entity8 in carefully dated @entity0 corpora lutea and cultured @entity0 luteinized granulosa cells. The mRNA abundance of BMPs was increased in the regressing corpus luteum in vivo (P < .01-.001). @entity0 @entity2 down-regulated @entity3 , @entity9 , and @entity8 transcripts both in vivo (P = .05-.001) and in vitro (P < .001), and decreased the mRNA abundance of BMP receptors ( @entity4 , @entity11 , @entity5 ; P < .05-.01) in vitro. Three BMPs were regulated by differential signaling pathways. H89, a protein kinase A inhibitor, increased the expression of both @entity3 (P < .05) and @entity9 (P < .05) while decreasing @entity8 (P < .01). PMA, a protein kinase C activator, decreased both @entity9 and @entity8 expression (P < .0001) while enhancing the mRNA abundance of @entity3 (P < .01). BMPs significantly down-regulated transcripts for @entity7 ( @entity7 ; P < .001) and @entity1 ( @entity1 ; P < .001), whereas up-regulating those of @entity10 ( @entity10 ; P < .01) and aromatase ( @entity6 ; P < .05-.01) in vitro, possessing an effect opposite to hCG but similar to Activin A. Like Activin A, @entity9 and @entity8 stimulated the expression of Inhibin/Activin subunits with a marked effect on @entity12 expression (P < .05-.01). These data confirm that BMPs are increased during luteal regression and negatively regulated by hCG via differential mechanisms, suggesting that BMPs are one of the mediators of luteolysis in @entity0 .

title: Bone morphogenetic proteins are mediators of luteolysis in the XXXX corpus luteum.

answer: @entity0


abstract: @entity1 in @entity3 ( @entity3 ) @entity0 is associated with a decline in the levels of growth factors, impairment of axonal transport and marked degeneration of basal forebrain cholinergic neurons (BFCNs). Neurogenesis persists in the adult @entity0 brain, and the stimulation of regenerative processes in the CNS is an attractive prospect for neuroreplacement therapy in @entity2 such as @entity3 . Currently, it is still not clear how the pathophysiological environment in the @entity3 brain affects stem cell biology. Previous studies investigating the effects of the b-amyloid (Ab) peptide on neurogenesis have been inconclusive, since both neurogenic and @entity5 effects on progenitor cell populations have been reported. In this study, we treated pluripotent @entity0 embryonic stem (hES) cells with @entity6 ( @entity6 ) as well as with fibrillar and oligomeric Ab1-40 and Ab1-42 (nM-  M concentrations) and thereafter studied the differentiation in vitro during 28-35 days. The process applied real time quantitative PCR, immunocytochemistry as well as functional studies of intracellular @entity4 signaling. Treatment with @entity6 promoted the differentiation into functionally mature BFCNs. In comparison to untreated cells, oligomeric Ab1-40 increased the number of functional neurons, whereas oligomeric Ab1-42 suppressed the number of functional neurons. Interestingly, oligomeric Ab exposure did not influence the number of hES cell-derived neurons compared with untreated cells, while in contrast fibrillar Ab1-40 and Ab1-42 induced gliogenesis. These findings indicate that Ab1-42 oligomers may impair the function of stem cell-derived neurons. We propose that it may be possible for future @entity3 therapies to promote the maturation of functional stem cell-derived neurons by altering the brain microenvironment with trophic support and by targeting different aggregation forms of Ab.

title: -amyloid 1-42 oligomers impair function of hu XXXX mbryonic stem cell-derived forebrain cholinergic neurons.

answer: @entity0


abstract: BACKGROUND: @entity2 is the leading cause of pediatric acquired @entity1 in many industrialized countries. The aim of this study was to estimate the incidence of @entity2 in acute stages in Taiwan, by linking the diagnosis code to medication and comparing the differences in epidemiological features with those of previous reports that used the diagnosis code alone. METHODS: We searched the National Health Insurance Research Database from 1997 to 2010. For the International Classification of Diseases, Ninth Revision ( @entity3 -9) set, all inpatients with a main diagnosis of @entity2 ( @entity3 -9, 446.1) were retrieved. For the @entity3 -9  +  intravenous immunoglobulin (IVIG) set, @entity2 in acute stages was defined as the disease stages requiring IVIG. The epidemiologic features were calculated and compared by both methods. RESULTS: The incidence rates for @entity0 under 5 years ranged from 21.5 to 68.5 per 100,000 @entity0 -years (average 49.1) for the @entity3 -9  +  IVIG set and from 48.5 to 82.8 per 100,000 @entity0 -years (average 74.9) for the @entity3 -9 set. Significant discrepancy in peak season estimation occurred in summer. The 5-year recurrence rate was 1.1% for the @entity3 -9  +  IVIG set and 4.5% for the @entity3 -9 set. The coronary complication rates were around 7.24% ( @entity3 -9  +  IVIG) and 6.48% ( @entity3 -9). CONCLUSION: Discrepancies occurred when different case definitions were used in claims data analysis. Previous reports might have overestimated the incidence, recurrence rate, and complication rate in older @entity0 . The new method might slightly underestimate them. The true incidence might lie in between.

title: Epidemiologic features of XXXX in acute stages in Taiwan, 1997-2010: Effect of different case definitions in claims data analysis.

answer: @entity2


abstract: OBJECTIVE: To explore the invasiveness of xenografts on @entity4 embryo @entity2 ( @entity2 ) after @entity6 ( @entity6 ) gene transfection. METHODS: Fresh @entity3 tissues were minced into 1-2 mm3 and transplanted on the @entity2 . There were three groups named as control group (Empt), plasma transfection group (Lipo), and @entity6 gene transfection group (P). The specimens were respectively investigated by microscope indifferent spots after implanting. The volume of the xenografts and the weight of xenografts in the termination time of the experiment were recorded. The invasiveness of xenografts was divided into four grades by pathological examination. Western blot analysis was performed to investigate @entity5 ( @entity5 ) and @entity6 protein in xenografts. RESULTS: @entity3 tissues can survive on @entity2 and the @entity1 cells may invade it on 5-7 days after implanting. At 9 d after implanting, the invasiveness grades in P group were 7 in grade 0, 1 in grade 2, 0 in grade 3. The expression of @entity6 protein in P group was significantly higher than that in Empt group (P < 0.05). The expression of @entity5 protein in P group was lower than that in Empt group (P < 0.05). CONCLUSION: The @entity1 model of @entity0 @entity3 on @entity2 was successfully established. The invasiveness of @entity3 xenografts was suppressed might be due to @entity6 gene transfection.

title: [Suppression to @entity3 xenografts of @entity4 embryo XXXX by tissue inhibitor of metalloproteinases-2].

answer: @entity2


abstract: OBJECTIVE: To explore the invasiveness of xenografts on @entity4 embryo @entity2 ( @entity2 ) after @entity6 ( @entity6 ) gene transfection. METHODS: Fresh @entity3 tissues were minced into 1-2 mm3 and transplanted on the @entity2 . There were three groups named as control group (Empt), plasma transfection group (Lipo), and @entity6 gene transfection group (P). The specimens were respectively investigated by microscope indifferent spots after implanting. The volume of the xenografts and the weight of xenografts in the termination time of the experiment were recorded. The invasiveness of xenografts was divided into four grades by pathological examination. Western blot analysis was performed to investigate @entity5 ( @entity5 ) and @entity6 protein in xenografts. RESULTS: @entity3 tissues can survive on @entity2 and the @entity1 cells may invade it on 5-7 days after implanting. At 9 d after implanting, the invasiveness grades in P group were 7 in grade 0, 1 in grade 2, 0 in grade 3. The expression of @entity6 protein in P group was significantly higher than that in Empt group (P < 0.05). The expression of @entity5 protein in P group was lower than that in Empt group (P < 0.05). CONCLUSION: The @entity1 model of @entity0 @entity3 on @entity2 was successfully established. The invasiveness of @entity3 xenografts was suppressed might be due to @entity6 gene transfection.

title: [Suppression to @entity3 xenografts of XXXX embryo @entity2 by tissue inhibitor of metalloproteinases-2].

answer: @entity4


abstract: OBJECTIVE: To explore the invasiveness of xenografts on @entity4 embryo @entity2 ( @entity2 ) after @entity6 ( @entity6 ) gene transfection. METHODS: Fresh @entity3 tissues were minced into 1-2 mm3 and transplanted on the @entity2 . There were three groups named as control group (Empt), plasma transfection group (Lipo), and @entity6 gene transfection group (P). The specimens were respectively investigated by microscope indifferent spots after implanting. The volume of the xenografts and the weight of xenografts in the termination time of the experiment were recorded. The invasiveness of xenografts was divided into four grades by pathological examination. Western blot analysis was performed to investigate @entity5 ( @entity5 ) and @entity6 protein in xenografts. RESULTS: @entity3 tissues can survive on @entity2 and the @entity1 cells may invade it on 5-7 days after implanting. At 9 d after implanting, the invasiveness grades in P group were 7 in grade 0, 1 in grade 2, 0 in grade 3. The expression of @entity6 protein in P group was significantly higher than that in Empt group (P < 0.05). The expression of @entity5 protein in P group was lower than that in Empt group (P < 0.05). CONCLUSION: The @entity1 model of @entity0 @entity3 on @entity2 was successfully established. The invasiveness of @entity3 xenografts was suppressed might be due to @entity6 gene transfection.

title: [Suppression to XXXX xenografts of @entity4 embryo @entity2 by tissue inhibitor of metalloproteinases-2].

answer: @entity3