abstract: BACKGROUND: Members of the legume genus Lupinus exude phloem 'spontaneously' from incisions made to the vasculature. This feature was exploited to document macromolecules present in exudate of white @entity10 (Lupinus albus [L.] cv Kiev mutant), in particular to identify proteins and RNA molecules, including microRNA (miRNA). RESULTS: Proteomic analysis tentatively identified 86 proteins from 130 spots collected from 2D gels analysed by partial @entity3 sequence determination using @entity0 / @entity0 . Analysis of a cDNA library constructed from exudate identified 609 unique transcripts. Both proteins and transcripts were classified into functional groups. The largest group of proteins comprised those involved in metabolism (24%), followed by protein modification/turnover (9%), redox regulation (8%), cell structural components (6%), stress and defence response (6%) with fewer in other groups. More prominent proteins were cyclophilin, ubiquitin, a @entity7 -rich RNA-binding protein, a group of proteins that comprise a @entity6 / @entity9 -based mechanism to scavenge @entity1 radicals, enzymes of glycolysis and other metabolism including @entity5 and @entity4 synthesis. Potential signalling macromolecules such as transcripts encoding proteins mediating @entity2 level and the Flowering locus T (FT) protein were also identified. From around 330 small RNA clones (18-25 nt) 12 were identified as probable miRNAs by homology with those from other species. miRNA composition of exudate varied with site of collection (e.g. upward versus downward translocation streams) and nutrition (e.g. @entity8 level). CONCLUSIONS: This is the first inventory of macromolecule composition of phloem exudate from a species in the Fabaceae, providing a basis to identify systemic signalling macromolecules with potential roles in regulating development, growth and stress response of legumes.

title: Macromolecular composition of phloem exudate from white XXXX (Lupinus albus L.).

answer: @entity10


abstract: BACKGROUND AND PURPOSE: This descriptive cohort study investigated a physical therapy program of pelvic-floor neuromuscular electrostimulation (NMES) combined with exercises, with the aim of developing a simple, inexpensive, and conservative treatment for postpartum genuine @entity2 (GSI). SUBJECTS: Eight female subjects with urodynamically established GSI persisting more than 3 months after delivery participated in the study. The subjects ranged in age from 24 to 37 years (X = 32, SD = 4.2). METHODS: This was a descriptive multiple-subject cohort study. Each subject received a total of nine treatment sessions during 3 consecutive weeks, consisting of two 15-minute sessions of NMES followed by a 15-minute pelvic-floor muscle exercise program. @entity0 also practiced daily pelvic-floor exercises during the 3-week treatment period. The treatment intervention was measured using three separate variables. Maximum muscle contractions (pretraining, during training, and post-training) were measured indirectly as pressure, using perineometry. Urine loss pretraining and posttraining was measured by means of a Pad test. Self-reported frequency of @entity1 was recorded daily throughout the period of the study, using a diary. Data were analyzed using a one-way repeated-measures analysis of variance (ANOVA), a Wilcoxon signed-ranks test, and a Friedman two-way ANOVA by ranks. RESULTS: The results indicated that maximum pressure generated by pelvic-floor contractions was greater and both the quantity of urine loss and the frequency of @entity1 were lower following the implementation of the physical therapy program. Five subjects became continent, and three others improved. A follow-up survey 1 year later confirmed the consistency of these results. CONCLUSION AND DISCUSSION: The results suggest that the proposed physical therapy program may influence postpartum GSI. Further studies are needed to validate this simple, inexpensive, and conservative physical therapy protocol. [Dumoulin C, Seaborne DE, Quirion-DeGirardi C, Sullivan SJ. Pelvic-floor rehabilitation, part 2: pelvic-floor reeducation with interferential currents and exercise in the treatment of genuine @entity2 in postpartum @entity0 --a cohort study.

title: Pelvic-floor rehabilitation, Part 2: Pelvic-floor reeducation with interferential currents and exercise in the treatment of genuine XXXX in postpartum @entity0 --a cohort study.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: This descriptive cohort study investigated a physical therapy program of pelvic-floor neuromuscular electrostimulation (NMES) combined with exercises, with the aim of developing a simple, inexpensive, and conservative treatment for postpartum genuine @entity2 (GSI). SUBJECTS: Eight female subjects with urodynamically established GSI persisting more than 3 months after delivery participated in the study. The subjects ranged in age from 24 to 37 years (X = 32, SD = 4.2). METHODS: This was a descriptive multiple-subject cohort study. Each subject received a total of nine treatment sessions during 3 consecutive weeks, consisting of two 15-minute sessions of NMES followed by a 15-minute pelvic-floor muscle exercise program. @entity0 also practiced daily pelvic-floor exercises during the 3-week treatment period. The treatment intervention was measured using three separate variables. Maximum muscle contractions (pretraining, during training, and post-training) were measured indirectly as pressure, using perineometry. Urine loss pretraining and posttraining was measured by means of a Pad test. Self-reported frequency of @entity1 was recorded daily throughout the period of the study, using a diary. Data were analyzed using a one-way repeated-measures analysis of variance (ANOVA), a Wilcoxon signed-ranks test, and a Friedman two-way ANOVA by ranks. RESULTS: The results indicated that maximum pressure generated by pelvic-floor contractions was greater and both the quantity of urine loss and the frequency of @entity1 were lower following the implementation of the physical therapy program. Five subjects became continent, and three others improved. A follow-up survey 1 year later confirmed the consistency of these results. CONCLUSION AND DISCUSSION: The results suggest that the proposed physical therapy program may influence postpartum GSI. Further studies are needed to validate this simple, inexpensive, and conservative physical therapy protocol. [Dumoulin C, Seaborne DE, Quirion-DeGirardi C, Sullivan SJ. Pelvic-floor rehabilitation, part 2: pelvic-floor reeducation with interferential currents and exercise in the treatment of genuine @entity2 in postpartum @entity0 --a cohort study.

title: Pelvic-floor rehabilitation, Part 2: Pelvic-floor reeducation with interferential currents and exercise in the treatment of genuine @entity2 in postpartum XXXX --a cohort study.

answer: @entity0


abstract: @entity2 ( @entity3 ) are ubiquitous in the marine environment, occurring at their highest environmental concentrations around urban centers. While they can occur naturally, the highest concentrations are mainly from @entity0 activities, and the primary sources are combustion products and petroleum. Two factors, lipid and organic @entity1 , control to a large extent the partitioning behavior of @entity3 in sediment, water, and tissue; the more hydrophobic a compound, the greater the partitioning to these phases. These two factors, along with the @entity4 -water partition coefficient, are the best predictors of this partitioning and can be used to determine @entity3 behavior and its bioavailability in the environment. It is well known that the lipid of organisms contains the highest levels of hydrophobic compounds such as @entity3 , and that organic @entity1 associated with sediment or dissolved in water can have the greatest influence on @entity3 bioavailability. Partitioning of combustion-derived @entity3 between water and sediment may be much less than predicted, possibly because associations with particles are much stronger than expected. This reduced partitioning may produce erroneous results in predicting bioaccumulation where uptake from water is important. Accumulation of @entity3 occurs in all marine organisms; however, there is a wide range in tissue concentrations from variable environmental concentrations, level and time of exposure, and species ability to metabolize these compounds. @entity3 generally partition into lipid-rich tissues, and their metabolites can be found in most tissues. In fish, liver and bile accumulate the highest levels of parent @entity3 and metabolites; hence, these are the best tissues to analyze when determining @entity3 exposure. In invertebrates, the highest concentrations can be found in the internal organs, such as the hepatopancreas, and tissue concentrations appear to follow seasonal cycles, which may be related to variations in lipid content or spawning cycles. The major route of uptake for @entity3 has been debated for years. For the more water-soluble @entity3 , it is believed that the main route of uptake is through ventilated water and that the more hydrophobic compounds are taken in mainly through ingestion of food or sediment. There are many variables, such as chemical hydrophobicity, uptake efficiency, feeding rate, and ventilatory volume, which may affect the outcome. The route of uptake may be an important issue for short-term events; however, under long-term exposure and equilibrium conditions between water, prey, and sediment, the route of uptake may be immaterial because the same tissue burdens will be achieved regardless of uptake routes.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Bioaccumulation of XXXX by marine organisms.

answer: @entity2


abstract: A variety of cytogenetic aberrations have been reported in sporadic and @entity4 . Rearrangements of the short arm of chromosome 3 (3p), trisomy 17, and nuclear hyperdiploidy have been reported to be common clonal chromosome changes. We analyzed a total of ten @entity1 -derived cell lines from @entity0 who underwent nephrectomy for @entity4 employing conventional cytogenetics. All @entity0 received an immunomodulatory therapy based on recombinant @entity3 ( @entity5 ). @entity1 stage and grade, histo- and cytopathology, and @entity0 ' response to immunotherapy were assessed and correlated statistically to rearrangement of 3p, trisomy 17, and nuclear hyperdiploidy. @entity6 as clonal aberration could be revealed only in @entity4 , whereas @entity1 with compact or tubulopapillary growth pattern lacked this abnormality (p < 0.002). One of 3 @entity0 with diploid or near-diploid karyotype (< or = 49 chromosomes) achieved a partial remission while two presented with stable disease after immunotherapy. In contrast, all 6 @entity0 with @entity1 progression upon @entity5 -based immunotherapy revealed @entity2 (> 49 chromosomes) karyotypes. The correlation between hyperdiploidy and @entity1 progression was found to be statistically significant (p < 0.029). Interestingly, the only @entity0 achieving an objective @entity1 remission after immunotherapy presented with a normal diploid karyotype. Our findings suggest @entity1 hyperdiploidy as an adverse prognostic factor in @entity4 @entity0 receiving @entity5 -based immunotherapy.

title: Cytogenetic studies in XXXX @entity0 receiving low-dose recombinant @entity3 -based immunotherapy.

answer: @entity4


abstract: A variety of cytogenetic aberrations have been reported in sporadic and @entity4 . Rearrangements of the short arm of chromosome 3 (3p), trisomy 17, and nuclear hyperdiploidy have been reported to be common clonal chromosome changes. We analyzed a total of ten @entity1 -derived cell lines from @entity0 who underwent nephrectomy for @entity4 employing conventional cytogenetics. All @entity0 received an immunomodulatory therapy based on recombinant @entity3 ( @entity5 ). @entity1 stage and grade, histo- and cytopathology, and @entity0 ' response to immunotherapy were assessed and correlated statistically to rearrangement of 3p, trisomy 17, and nuclear hyperdiploidy. @entity6 as clonal aberration could be revealed only in @entity4 , whereas @entity1 with compact or tubulopapillary growth pattern lacked this abnormality (p < 0.002). One of 3 @entity0 with diploid or near-diploid karyotype (< or = 49 chromosomes) achieved a partial remission while two presented with stable disease after immunotherapy. In contrast, all 6 @entity0 with @entity1 progression upon @entity5 -based immunotherapy revealed @entity2 (> 49 chromosomes) karyotypes. The correlation between hyperdiploidy and @entity1 progression was found to be statistically significant (p < 0.029). Interestingly, the only @entity0 achieving an objective @entity1 remission after immunotherapy presented with a normal diploid karyotype. Our findings suggest @entity1 hyperdiploidy as an adverse prognostic factor in @entity4 @entity0 receiving @entity5 -based immunotherapy.

title: Cytogenetic studies in @entity4 @entity0 receiving low-dose recombinant XXXX -based immunotherapy.

answer: @entity3


abstract: A variety of cytogenetic aberrations have been reported in sporadic and @entity4 . Rearrangements of the short arm of chromosome 3 (3p), trisomy 17, and nuclear hyperdiploidy have been reported to be common clonal chromosome changes. We analyzed a total of ten @entity1 -derived cell lines from @entity0 who underwent nephrectomy for @entity4 employing conventional cytogenetics. All @entity0 received an immunomodulatory therapy based on recombinant @entity3 ( @entity5 ). @entity1 stage and grade, histo- and cytopathology, and @entity0 ' response to immunotherapy were assessed and correlated statistically to rearrangement of 3p, trisomy 17, and nuclear hyperdiploidy. @entity6 as clonal aberration could be revealed only in @entity4 , whereas @entity1 with compact or tubulopapillary growth pattern lacked this abnormality (p < 0.002). One of 3 @entity0 with diploid or near-diploid karyotype (< or = 49 chromosomes) achieved a partial remission while two presented with stable disease after immunotherapy. In contrast, all 6 @entity0 with @entity1 progression upon @entity5 -based immunotherapy revealed @entity2 (> 49 chromosomes) karyotypes. The correlation between hyperdiploidy and @entity1 progression was found to be statistically significant (p < 0.029). Interestingly, the only @entity0 achieving an objective @entity1 remission after immunotherapy presented with a normal diploid karyotype. Our findings suggest @entity1 hyperdiploidy as an adverse prognostic factor in @entity4 @entity0 receiving @entity5 -based immunotherapy.

title: Cytogenetic studies in @entity4 XXXX receiving low-dose recombinant @entity3 -based immunotherapy.

answer: @entity0


abstract: @entity5 and its consequences account for most morbidity and mortality in Western countries. @entity5 develops over a period of decades and has a complex pathogenesis. It is a disease of the intima and primarily involves four cell types, i.e. endothelial and vascular smooth muscle cells, monocytes and platelets. In recent years, elucidation of the cellular and molecular mechanisms of these cells, and their alterations by cardiovascular risk factors and in @entity5 , has markedly expanded knowledge of this disease. In particular, it became clear that endothelial cells play a crucial role in the regulation of platelet function and coagulation, as well as vascular tone and structure. Interestingly, @entity4 occurs early on in the presence of cardiovascular risk factors such as @entity3 , @entity1 and @entity0 . This could lead to adhesion of circulating platelets and monocytes, increased accumulation of lipids in the subintima, increased contraction, migration and proliferation of vascular smooth muscle cells. The fact that @entity5 develops only in some but not in other parts of the circulation, however, has rarely been considered. With the development of molecular biology it has now become possible to clone differentially expressed genes in vessels with or without @entity5 ; this in turn makes it possible to characterize better the molecular and cellular mechanisms of the disease. The search for such candidate genes could form the basis for future genetic interventions. This therapeutic approach is likely to assume clinical importance, particularly in monogenetic diseases (i.e. @entity6 ), while its use in complex polygenetic diseases such as @entity5 is more difficult. @entity2 , however, may be accessible to gene therapy earlier on as it is accessible to local gene transfection.

title: [Molecular medicine and gene therapy as exemplified with arteriosclerosis and XXXX ].

answer: @entity2


abstract: @entity12 , often used synonymously with @entity11 , is a form of @entity2 in the peritonsillar area associated with a @entity8 and caused by the strict anaerobic species Fusobacterium necrophorum. The @entity5 formed affects the internal jugular vein, from which the bacteria are seeded out in the bloodstream and cause @entity7 . @entity3 is a common complication with an often fatal outcome. @entity12 is very rare and is referred to as the 'forgotten disease'. It is probably frequently overlooked in clinical practice in its early and milder forms such as @entity10 (sore throat) and peritonsillar abscess. F. necrophorum frequently participates in these @entity2 and is thus suspected to have an etiological role in @entity11 . Similarly, F. necrophorum seems to play an important role in @entity13 ( @entity13 ) and this disease is also included in the @entity12 complex. Diagnosis of @entity2 complex seeks to disclose F. necrophorum in swab samples or blood culture. The most commonly used therapy is @entity6 in combination with @entity0 or @entity1 . @entity9 is also an option, especially in cases of @entity0 @entity4 .

title: XXXX in humans.

answer: @entity12


abstract: The repair of @entity2 , @entity2 , is technically challenging and controversial. The approach to repair has shifted from thoracic to open abdominal to laparoscopic, which appears to be the current standard. High recurrence rates have been reported with laparoscopic procedures, but these are anatomic recurrences that are largely asymptomatic. Symptomatic recurrences with laparoscopic procedures appear to be similar to those seen with open abdominal procedures, but without the additional morbidity conferred by laparotomy. In the last decade, several studies have reported improved rates of recurrence using prosthetic meshes that have decreased even radiologic recurrence rates to below 5%. However, this has come at the price of rare but serious complications such as @entity4 and @entity0 . Mesh repair appears to be associated with a higher perioperative rate of @entity3 , which tends to resolve within the intervening months. Biologic meshes have been implemented in an attempt to obtain the buttressing effect of prosthetic meshes without the complications of @entity1 . Early results have not proven biologic meshes to be as effective in reducing recurrence rates as prosthetic meshes, but there are currently no reports of @entity4 . Continued research is needed to elicit the optimal type of repair and mesh.

title: Repair of the XXXX .

answer: @entity2


abstract: AIM: @entity2 ( @entity2 ) is a common complication in @entity3 . The aim of this study is to investigate the association between RIFLE and AKIN classifications with mortality in @entity3 -associated @entity2 . METHODS: A retrospective study was conducted in @entity0 with @entity3 admitted to tertiary hospitals in Brazil. The association between RIFLE and AKIN classifications with mortality was investigated. Univariate and multivariate analysis was performed to investigate risk factors for @entity1 . RESULTS: A total of 287 @entity0 were included, with an average age of 37    16 years, and 80.8% were male. Overall mortality was 13%. There was a significant association between these classifications and @entity1 . Among non-survivors, 86% were in the class 'failure' and AKIN 3. Increased mortality was observed according to the worse classifications: 'risk' (R; 2%), 'injury' (I; 8%) and 'failure' (F; 23%), as well as in AKIN 1 (2%), AKIN 2 (8%) and AKIN 3 (23%) (P < 0.0001). The worst classifications were significantly associated with @entity1 : RIFLE F (odds ratio = 11.6, P = 0.018) and AKIN 3 (odds ratio = 12.8, P = 0.013). Receiver-operator curve for @entity0 with @entity2 showed high areas under the curve (0.71, 95% confidence interval = 0.67-0.74) for both RIFLE and AKIN classifications in determining the sensitivity for mortality. CONCLUSION: There is a significant association between RIFLE and AKIN classifications with mortality in @entity0 with @entity3 . Initiation of dialysis in @entity0 with RIFLE F and AKIN 3 should always be considered.

title: RIFLE and @entity2 Network classifications predict mortality in XXXX -associated @entity2 .

answer: @entity3


abstract: AIM: @entity2 ( @entity2 ) is a common complication in @entity3 . The aim of this study is to investigate the association between RIFLE and AKIN classifications with mortality in @entity3 -associated @entity2 . METHODS: A retrospective study was conducted in @entity0 with @entity3 admitted to tertiary hospitals in Brazil. The association between RIFLE and AKIN classifications with mortality was investigated. Univariate and multivariate analysis was performed to investigate risk factors for @entity1 . RESULTS: A total of 287 @entity0 were included, with an average age of 37    16 years, and 80.8% were male. Overall mortality was 13%. There was a significant association between these classifications and @entity1 . Among non-survivors, 86% were in the class 'failure' and AKIN 3. Increased mortality was observed according to the worse classifications: 'risk' (R; 2%), 'injury' (I; 8%) and 'failure' (F; 23%), as well as in AKIN 1 (2%), AKIN 2 (8%) and AKIN 3 (23%) (P < 0.0001). The worst classifications were significantly associated with @entity1 : RIFLE F (odds ratio = 11.6, P = 0.018) and AKIN 3 (odds ratio = 12.8, P = 0.013). Receiver-operator curve for @entity0 with @entity2 showed high areas under the curve (0.71, 95% confidence interval = 0.67-0.74) for both RIFLE and AKIN classifications in determining the sensitivity for mortality. CONCLUSION: There is a significant association between RIFLE and AKIN classifications with mortality in @entity0 with @entity3 . Initiation of dialysis in @entity0 with RIFLE F and AKIN 3 should always be considered.

title: RIFLE and XXXX Network classifications predict mortality in @entity3 -associated @entity2 .

answer: @entity2


abstract: AIM: @entity2 ( @entity2 ) is a common complication in @entity3 . The aim of this study is to investigate the association between RIFLE and AKIN classifications with mortality in @entity3 -associated @entity2 . METHODS: A retrospective study was conducted in @entity0 with @entity3 admitted to tertiary hospitals in Brazil. The association between RIFLE and AKIN classifications with mortality was investigated. Univariate and multivariate analysis was performed to investigate risk factors for @entity1 . RESULTS: A total of 287 @entity0 were included, with an average age of 37    16 years, and 80.8% were male. Overall mortality was 13%. There was a significant association between these classifications and @entity1 . Among non-survivors, 86% were in the class 'failure' and AKIN 3. Increased mortality was observed according to the worse classifications: 'risk' (R; 2%), 'injury' (I; 8%) and 'failure' (F; 23%), as well as in AKIN 1 (2%), AKIN 2 (8%) and AKIN 3 (23%) (P < 0.0001). The worst classifications were significantly associated with @entity1 : RIFLE F (odds ratio = 11.6, P = 0.018) and AKIN 3 (odds ratio = 12.8, P = 0.013). Receiver-operator curve for @entity0 with @entity2 showed high areas under the curve (0.71, 95% confidence interval = 0.67-0.74) for both RIFLE and AKIN classifications in determining the sensitivity for mortality. CONCLUSION: There is a significant association between RIFLE and AKIN classifications with mortality in @entity0 with @entity3 . Initiation of dialysis in @entity0 with RIFLE F and AKIN 3 should always be considered.

title: RIFLE and @entity2 Network classifications predict mortality in @entity3 -associated XXXX .

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ) contributes to @entity2 in haemodialysis (HD) @entity0 . Few controlled studies have addressed interventions to reduce @entity5 but non- @entity4 -based @entity7 binders may be beneficial. No published randomized study to date has assessed the effect of @entity9 (LC) on @entity5 progression. METHODS: We conducted a pilot randomized controlled trial to determine the effect of LC on @entity5 . Forty-five HD @entity0 were randomized to either LC or @entity8 (CC). Primary outcome was change in aortic @entity5 after 18 months. Secondary outcomes included superficial femoral artery (SFA) @entity5 , @entity3 ( @entity3 ) of lumbar spine and serum markers of mineral metabolism. At baseline, 6 and 18 month computed tomography was performed to measure @entity5 and @entity3 . A random effect linear regression model was performed to assess differences. RESULTS: Thirty @entity0 completed the study (17 LC, 13 CC); baseline median age 58 years, 38% @entity1 , 64% male. Ninety-three per cent had aortic @entity5 at commencement and 87% showed progression. At 18 months, there was significantly less aortic @entity5 progression with LC than CC (adjusted difference -98.1 (-149.4, -46.8) Hounsfield units (HU), P < 0.001). There was also a non-significant reduction with LC in left SFA @entity5 (-25.8 (-67.7, 16.1) HU, P = 0.2) and right SFA @entity5 (-35.9 (-77.8, 5.9) HU, P = 0.09). There was no difference in lumbar spine @entity3 and serum @entity7 , @entity4 and parathyroid hormone levels between groups. Limitations to the study include small sample size and loss to follow up. CONCLUSIONS: @entity9 was associated with reduced progression of @entity6 compared with CC in HD @entity0 over 18 months.

title: Attenuation of @entity6 with @entity9 versus @entity4 -based XXXX binders in haemodialysis: A pilot randomized controlled trial.

answer: @entity7


abstract: BACKGROUND: @entity5 ( @entity5 ) contributes to @entity2 in haemodialysis (HD) @entity0 . Few controlled studies have addressed interventions to reduce @entity5 but non- @entity4 -based @entity7 binders may be beneficial. No published randomized study to date has assessed the effect of @entity9 (LC) on @entity5 progression. METHODS: We conducted a pilot randomized controlled trial to determine the effect of LC on @entity5 . Forty-five HD @entity0 were randomized to either LC or @entity8 (CC). Primary outcome was change in aortic @entity5 after 18 months. Secondary outcomes included superficial femoral artery (SFA) @entity5 , @entity3 ( @entity3 ) of lumbar spine and serum markers of mineral metabolism. At baseline, 6 and 18 month computed tomography was performed to measure @entity5 and @entity3 . A random effect linear regression model was performed to assess differences. RESULTS: Thirty @entity0 completed the study (17 LC, 13 CC); baseline median age 58 years, 38% @entity1 , 64% male. Ninety-three per cent had aortic @entity5 at commencement and 87% showed progression. At 18 months, there was significantly less aortic @entity5 progression with LC than CC (adjusted difference -98.1 (-149.4, -46.8) Hounsfield units (HU), P < 0.001). There was also a non-significant reduction with LC in left SFA @entity5 (-25.8 (-67.7, 16.1) HU, P = 0.2) and right SFA @entity5 (-35.9 (-77.8, 5.9) HU, P = 0.09). There was no difference in lumbar spine @entity3 and serum @entity7 , @entity4 and parathyroid hormone levels between groups. Limitations to the study include small sample size and loss to follow up. CONCLUSIONS: @entity9 was associated with reduced progression of @entity6 compared with CC in HD @entity0 over 18 months.

title: Attenuation of @entity6 with XXXX versus @entity4 -based @entity7 binders in haemodialysis: A pilot randomized controlled trial.

answer: @entity9


abstract: BACKGROUND: @entity5 ( @entity5 ) contributes to @entity2 in haemodialysis (HD) @entity0 . Few controlled studies have addressed interventions to reduce @entity5 but non- @entity4 -based @entity7 binders may be beneficial. No published randomized study to date has assessed the effect of @entity9 (LC) on @entity5 progression. METHODS: We conducted a pilot randomized controlled trial to determine the effect of LC on @entity5 . Forty-five HD @entity0 were randomized to either LC or @entity8 (CC). Primary outcome was change in aortic @entity5 after 18 months. Secondary outcomes included superficial femoral artery (SFA) @entity5 , @entity3 ( @entity3 ) of lumbar spine and serum markers of mineral metabolism. At baseline, 6 and 18 month computed tomography was performed to measure @entity5 and @entity3 . A random effect linear regression model was performed to assess differences. RESULTS: Thirty @entity0 completed the study (17 LC, 13 CC); baseline median age 58 years, 38% @entity1 , 64% male. Ninety-three per cent had aortic @entity5 at commencement and 87% showed progression. At 18 months, there was significantly less aortic @entity5 progression with LC than CC (adjusted difference -98.1 (-149.4, -46.8) Hounsfield units (HU), P < 0.001). There was also a non-significant reduction with LC in left SFA @entity5 (-25.8 (-67.7, 16.1) HU, P = 0.2) and right SFA @entity5 (-35.9 (-77.8, 5.9) HU, P = 0.09). There was no difference in lumbar spine @entity3 and serum @entity7 , @entity4 and parathyroid hormone levels between groups. Limitations to the study include small sample size and loss to follow up. CONCLUSIONS: @entity9 was associated with reduced progression of @entity6 compared with CC in HD @entity0 over 18 months.

title: Attenuation of @entity6 with @entity9 versus XXXX -based @entity7 binders in haemodialysis: A pilot randomized controlled trial.

answer: @entity4


abstract: BACKGROUND: @entity5 ( @entity5 ) contributes to @entity2 in haemodialysis (HD) @entity0 . Few controlled studies have addressed interventions to reduce @entity5 but non- @entity4 -based @entity7 binders may be beneficial. No published randomized study to date has assessed the effect of @entity9 (LC) on @entity5 progression. METHODS: We conducted a pilot randomized controlled trial to determine the effect of LC on @entity5 . Forty-five HD @entity0 were randomized to either LC or @entity8 (CC). Primary outcome was change in aortic @entity5 after 18 months. Secondary outcomes included superficial femoral artery (SFA) @entity5 , @entity3 ( @entity3 ) of lumbar spine and serum markers of mineral metabolism. At baseline, 6 and 18 month computed tomography was performed to measure @entity5 and @entity3 . A random effect linear regression model was performed to assess differences. RESULTS: Thirty @entity0 completed the study (17 LC, 13 CC); baseline median age 58 years, 38% @entity1 , 64% male. Ninety-three per cent had aortic @entity5 at commencement and 87% showed progression. At 18 months, there was significantly less aortic @entity5 progression with LC than CC (adjusted difference -98.1 (-149.4, -46.8) Hounsfield units (HU), P < 0.001). There was also a non-significant reduction with LC in left SFA @entity5 (-25.8 (-67.7, 16.1) HU, P = 0.2) and right SFA @entity5 (-35.9 (-77.8, 5.9) HU, P = 0.09). There was no difference in lumbar spine @entity3 and serum @entity7 , @entity4 and parathyroid hormone levels between groups. Limitations to the study include small sample size and loss to follow up. CONCLUSIONS: @entity9 was associated with reduced progression of @entity6 compared with CC in HD @entity0 over 18 months.

title: Attenuation of XXXX with @entity9 versus @entity4 -based @entity7 binders in haemodialysis: A pilot randomized controlled trial.

answer: @entity6


abstract: Parental behaviors involve complex social recognition and memory processes and interactive behavior with @entity0 that can greatly facilitate healthy @entity0 family life. Fathers play a substantial role in @entity0 care in a small but significant number of mammals, including @entity0 . However, the brain mechanism that controls male parental behavior is much less understood than that controlling female parental behavior. Fathers of non-monogamous laboratory ICR @entity1 are an interesting model for examining the factors that influence paternal responsiveness because sires can exhibit maternal-like parental care (retrieval of pups) when separated from their pups along with their pairmates because of olfactory and auditory signals from the dams. Here we tested whether paternal behavior is related to femininity by the aromatization of @entity3 . For this purpose, we measured the immunoreactivity of aromatase [ @entity5 ( @entity5 )], which synthesizes @entity2 from @entity4 , in nine brain regions of the sire. We observed higher levels of aromatase expression in these areas of the sire brain when they engaged in communicative interactions with dams in separate cages. Interestingly, the number of nuclei with aromatase immunoreactivity in sires left together with maternal mates in the home cage after pup-removing was significantly larger than that in sires housed with a whole family. The capacity of sires to retrieve pups was increased following a period of 5 days spent with the pups as a whole family after parturition, whereas the acquisition of this ability was suppressed in sires treated daily with an aromatase inhibitor. The results demonstrate that the dam significantly stimulates aromatase in the male brain and that the presence of the pups has an inhibitory effect on this increase. These results also suggest that brain aromatization regulates the initiation, development, and maintenance of paternal behavior in the ICR male @entity1 .

title: Paternal Retrieval Behavior Regulated by Brain Estrogen Synthetase (Aromatase) in XXXX Sires that Engage in Communicative Interactions with Pairmates.

answer: @entity1


abstract: The appendectomies for @entity2 are the most frequent surgical interventions (43.6%) in our service. The recent studies demonstrated the feasibility and the economical gain of the early oral feeding vs. classic oral feeding, after elective digestive surgery. We wanted to spread these results therefore to the appendectomy for @entity2 . It is about a prospective survey carrying on 110 @entity0 also left in two groups, and comparing the classic postoperative oral feeding vs. the early postoperative oral feeding on one year. The two groups were comparable and the studied parameters were : the length of the @entity1 , the hospitable morbidity, the length of the hospitalization and the cost of the hold in charge. The length of the @entity1 was not different in the two groups as well as the morbidity. The difference of the median length of hospitalization in the two groups was not meaningful. The cost of the hold in charge was meaningfully more elevated in the group with classic postoperative feeding. In conclusion, the early postoperative oral feeding in our survey doesn't reduce the length of the @entity1 and don't drag a morbidity anymore that the classic oral feeding. However if it doesn't shorten the length of the hospitalization, it drags a reduction of the cost of the hold in charge. There is a gain therefore precociously to nourish the @entity0 after appendectomy for @entity2 .

title: [Early oral feeding versus classic oral feeding after appendicectomy for XXXX ].

answer: @entity2


abstract: Chronic mechanical stress of the heart by @entity2 is a primary cause of @entity7 . The cardiac renin-angiotensin system is often found activated in conditions of increased afterload or mechanical stress of myocytes. Cardiac expression of angiotensinogen and angiotensin-converting enzyme ( @entity6 ) is increased resulting in elevated cardiac @entity5 formation. This has been demonstrated in stretched cardiac myocytes in vitro as well as in animal models of pressure overload @entity4 ( @entity8 and spontaneously @entity2 @entity1 ) and in @entity0 pressure overload @entity4 ( @entity3 ). Functional consequences of elevated @entity5 levels may be vasoconstriction of the coronary vasculature and a deterioration of diastolic function of the hypertrophied heart. Local formation of @entity5 may also have proliferative effects on cardiac myocytes and connective tissue cells. @entity5 may, thus, be an important factor causing development and progression of @entity7 by itself. Blockade of the renin-angiotensin system has been found to be an effective treatment of @entity2 , probably better than any other antihypertensive medication. Regression of @entity7 has been achieved by blockade of the @entity5 pathway either by administration of an angiotensin-converting enzyme inhibitor or an @entity9 blocker. The animal model of @entity8 has been used to show beneficial effects of blockade of the renin-angiotensin system on @entity4 and survival. In this @entity1 model regression of @entity7 by @entity6 -inhibition or @entity9 blockade could be demonstrated by serial echocardiographic analyses while afterload of the left ventricle was still elevated.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Role of the cardiac renin-angiotensin system in XXXX ].

answer: @entity2


abstract: OBJECT: Over the past 15 years, vertebroplasty has emerged as a treatment for @entity5 . This technique, however, does not restore vertebral height and is associated with a high rate of cement leakage. Recently, kyphoplasty was developed in an effort to circumvent this problem. Although its immediate results have been reported, it is unclear whether the benefits endure. METHODS: Seventy-eight consecutive @entity0 underwent 188 kyphoplasty procedures. The @entity0 responded to Short Form-36 (SF-36) questionnaires, a visual analog scale (VAS) for @entity2 rating, and the @entity4 index (ODI) instrument; additionally they underwent detailed neurological and radiographic examinations pre- and postoperatively. The preoperative SF-36, VAS, and ODI scores, the neurological examination results, and the radiographic data were compared with the postoperative findings. Thirteen @entity0 died of disease progression or unrelated illness. Of the surviving @entity0 , complete data were available in 62% (minimum follow-up period 12 months, mean 18 months). Complications included one @entity3 and five cases of asymptomatic cement extravasation. No case of @entity1 occurred during the follow-up period. Significant improvements in seven measures of the SF-36 inventory as well as on the ODI and VAS were noted early postoperatively, and these persisted throughout the follow-up period, despite a statistically insignificant decline in the measure of general health at last follow-up examination. CONCLUSIONS: Kyphoplasty is an effective treatment for @entity5 . The benefits presented in the early postoperative period and persisted at 1 year posttreatment.

title: Kyphoplasty for XXXX : 1-year clinical outcomes from a prospective study.

answer: @entity5


abstract: @entity2 affects @entity0 and @entity0 of all ages, leading to @entity1 and high financial costs. The evaluation of the @entity0 should clarify the pathophysiology of the symptoms and provide guidance in choosing the appropriate treatment. A comprehensive history and physical examination including endoscopic assessment is able to identify the cause of most cases of @entity2 . If necessary, functional methods can be used to confirm the diagnosis. @entity0 selection for suitable treatment is most important and should be based on clinical and physiologic findings. Conservative dietary or medical treatment is often effective, when the symptoms are mild. Biofeedback therapy is effective in most @entity0 . It has no side effects and is well tolerated. Structural damage to the anus may be repaired by surgery, like sphincter repair, the best treatment of selective sphincter defects. Neoanal sphincters and artificial sphincters are the last possibility after failed surgery and before colostomy. They are less attractive because of technical difficulties and low success rate. A multidisciplinary approach to treatment has the potential to improve the outcome for @entity0 with @entity2 .

title: XXXX : evaluation and treatment.

answer: @entity2


abstract: PURPOSE: To evaluate the development of @entity2 in a primate model of sensory strabismus and @entity0 . METHODS: Four macaque monkeys had alternating tarsorraphy beginning within 24 hours of birth. One eye was closed for 25 days, and when it opened, the second eye immediately was closed for the next 25 days. Cycloplegic refractions and axial lengths were determined prospectively for three animals for 1 year or more. These data were compared to those of three unsutured control macaques raised under otherwise similar conditions. RESULTS: Each experimental animal developed @entity5 and @entity0 . The first @entity1 were significantly more hypermetropic than the control eyes at 1 month of age (+7.25 D +/- 1.95 D versus +1.92 D +/- 1.27 D; P < 0.02) and remained significantly more hypermetropic throughout the study. The second @entity1 were more hypermetropic than the control eyes at 1 month (+2.42 D +/- 2.13 D versus +1.92 D +/- 1.27 D; P = 0.20), but less hypermetropic than the first @entity1 . The rate of emmetropization was slightly faster for the first @entity1 than for the control eyes (-0.12 D/month compared to -0.03 D/month). The mean axial length measurements of the experimental and control eyes were the same at 1 month, and their rates of change over time were identical. CONCLUSIONS: Persistent @entity3 was produced by a brief period of reverse neonatal eyelid closure in a model of @entity6 . It is suggested that infantile lid closure, @entity0 , or @entity4 after neonatal visual disruption may be associated with a failure of normal emmetropization.

title: XXXX in a primate model of strabismus and @entity6 .

answer: @entity2


abstract: PURPOSE: To evaluate the development of @entity2 in a primate model of sensory strabismus and @entity0 . METHODS: Four macaque monkeys had alternating tarsorraphy beginning within 24 hours of birth. One eye was closed for 25 days, and when it opened, the second eye immediately was closed for the next 25 days. Cycloplegic refractions and axial lengths were determined prospectively for three animals for 1 year or more. These data were compared to those of three unsutured control macaques raised under otherwise similar conditions. RESULTS: Each experimental animal developed @entity5 and @entity0 . The first @entity1 were significantly more hypermetropic than the control eyes at 1 month of age (+7.25 D +/- 1.95 D versus +1.92 D +/- 1.27 D; P < 0.02) and remained significantly more hypermetropic throughout the study. The second @entity1 were more hypermetropic than the control eyes at 1 month (+2.42 D +/- 2.13 D versus +1.92 D +/- 1.27 D; P = 0.20), but less hypermetropic than the first @entity1 . The rate of emmetropization was slightly faster for the first @entity1 than for the control eyes (-0.12 D/month compared to -0.03 D/month). The mean axial length measurements of the experimental and control eyes were the same at 1 month, and their rates of change over time were identical. CONCLUSIONS: Persistent @entity3 was produced by a brief period of reverse neonatal eyelid closure in a model of @entity6 . It is suggested that infantile lid closure, @entity0 , or @entity4 after neonatal visual disruption may be associated with a failure of normal emmetropization.

title: @entity2 in a primate model of strabismus and XXXX .

answer: @entity6


abstract: PURPOSE: The retinal vascular tree exhibits fractal characteristics. These findings relate to the mechanisms involved in the vascularization process and to the objective morphologic characterization of retinal vessels using fractal analysis. Although normal retinas show uniform patterns of blood vessels, in pathologic retinas with central vein or @entity1 , the patterns are irregular. Because the generalized box fractal dimension fails to differentiate successfully between normal and abnormal retinal vessels in 60 degrees @entity3 angiograms, the authors have further investigated this problem using the local connected fractal dimension (alpha). METHODS: The authors studied 24 digitized 60 degrees @entity3 angiograms of @entity0 with normal retinas and 5 angiograms of @entity0 with central @entity2 . The pointwise method estimated the local complexity of the angiogram within a finite window centered on those pixels that belong to the retinal vessels. Color-coded dimensional images of the angiograms were constructed by plotting the pixels forming the object with a color that corresponded to specific values of alpha +/- delta alpha. RESULTS: The color-coded representation allowed recognition of areas with increased or decreased local angiogram complexity. The alpha distributions showed differences between normal and pathologic retinas, which overcomes problems encountered when using the methods of calculating the generalized fractal dimensions. A multivariate linear discriminant function using parameters from the alpha distribution and a further fractal parameter--lacunarity--reclassified 23 of the 24 normal and 4 of the 5 pathologic angiograms in their original groups (total: 92.1% correct). CONCLUSIONS: This methodology may be used for automatic detection and objective characterization of local @entity4 .

title: Local connected fractal dimensions and lacunarity analyses of 60 degrees XXXX angiograms.

answer: @entity3


abstract: Soft tissue neoplasms with features of both @entity6 and @entity11 ( @entity11 ) have been increasingly recognized in recent years. To date, only a single case of this entity has been documented in the gastrointestinal tract (sigmoid colon). We herein describe 2 new cases of this entity. For comparison, we reevaluated 12 classic @entity2 for the perineurial cell component. The 2 hybrid @entity11 were detected incidentally in the gastric antrum and the vermiform appendix in a 50-year-old @entity0 and a 17-year-old @entity0 during surgery for @entity3 and @entity5 -like symptoms, respectively. None of the @entity0 had @entity10 1 or 2. @entity0 were alive with no evidence of recurrence or new @entity1 at 8 and 12 months, respectively. The @entity1 measured 1.2 cm and 1.5 cm in size. Histologically, they showed prominent storiform, lamellar, and fascicular patterns. Notably, both lacked peripheral lymphoid cuffs and the trabecular pattern of @entity2 . Both @entity1 coexpressed protein @entity8 (>= 80%), @entity7 (80%), and the perineurial cell markers (20% to 40% of @entity1 cells). The perineurial cell component formed alternating fascicles with @entity8 -positive cells throughout the @entity1 . Reevaluation of 12 classic @entity2 showed isolated @entity9 /epithelial membrane antigen-positive cells. However, 4 @entity6 (33%) strongly expressed @entity4 transporter-1 in most of the @entity1 cells indicating its limited specificity in this setting. Compared with @entity2 , @entity7 expression was stronger and more diffuse in hybrid @entity11 . We conclude that hybrid @entity11 are distinct from @entity2 , both histologically and immunohistochemically.

title: XXXX of the gastrointestinal tract: a clinicopathologic study of 2 cases and reappraisal of perineurial cells in @entity2 .

answer: @entity11


abstract: Soft tissue neoplasms with features of both @entity6 and @entity11 ( @entity11 ) have been increasingly recognized in recent years. To date, only a single case of this entity has been documented in the gastrointestinal tract (sigmoid colon). We herein describe 2 new cases of this entity. For comparison, we reevaluated 12 classic @entity2 for the perineurial cell component. The 2 hybrid @entity11 were detected incidentally in the gastric antrum and the vermiform appendix in a 50-year-old @entity0 and a 17-year-old @entity0 during surgery for @entity3 and @entity5 -like symptoms, respectively. None of the @entity0 had @entity10 1 or 2. @entity0 were alive with no evidence of recurrence or new @entity1 at 8 and 12 months, respectively. The @entity1 measured 1.2 cm and 1.5 cm in size. Histologically, they showed prominent storiform, lamellar, and fascicular patterns. Notably, both lacked peripheral lymphoid cuffs and the trabecular pattern of @entity2 . Both @entity1 coexpressed protein @entity8 (>= 80%), @entity7 (80%), and the perineurial cell markers (20% to 40% of @entity1 cells). The perineurial cell component formed alternating fascicles with @entity8 -positive cells throughout the @entity1 . Reevaluation of 12 classic @entity2 showed isolated @entity9 /epithelial membrane antigen-positive cells. However, 4 @entity6 (33%) strongly expressed @entity4 transporter-1 in most of the @entity1 cells indicating its limited specificity in this setting. Compared with @entity2 , @entity7 expression was stronger and more diffuse in hybrid @entity11 . We conclude that hybrid @entity11 are distinct from @entity2 , both histologically and immunohistochemically.

title: @entity11 of the gastrointestinal tract: a clinicopathologic study of 2 cases and reappraisal of perineurial cells in XXXX .

answer: @entity2


abstract: BACKGROUND AND AIMS: Increasing use of diagnostic radiography has led to concern about the malignant potential of ionizing radiation. We aimed to quantify the @entity6 ( @entity6 ) from diagnostic medical imaging in @entity0 with @entity2 ( @entity2 ) and to identify which @entity0 are at greatest risk for high amounts of image-related radiation exposure. @entity0 AND METHODS: A retrospective chart review of pediatric @entity2 @entity0 seen between January 1 and May 30, 2008 was conducted. The effective dose of radiation received from all of the radiology tests performed during the course of each @entity0 's treatment was estimated using typical effective doses and our institution's computed tomography dose index. A @entity6 >= 50 @entity5 was considered high. RESULTS: Complete records were available for 257 of 372 screened subjects. One hundred seventy-one had @entity3 ( @entity3 ) and 86 had @entity4 ( @entity4 ). The mean @entity6 was 17.56    15.91 @entity5 and was greater for @entity0 with @entity3 than for those with @entity4 (20.5    17.5 vs 11.7    9.9 @entity5 , P < 0.0001). Fifteen @entity0 (5.8%) had a @entity6 >= 50 @entity5 , including 14 of 171 (8.2%) with @entity3 and 1 of 86 (1.2%) with @entity4 (P = 0.02). In @entity0 with @entity3 , factors associated with high @entity6 per multivariate analysis were any @entity2 -related surgery (odds ratio 42, 95% confidence interval 8-223, P < 0.0001) and platelet count (odds ratio 16, 95% confidence interval 1.5-175, P = 0.02). CONCLUSIONS: Although all doses of ionizing radiation have some @entity1 -inducing potential, a small but important percentage of @entity0 with @entity2 are exposed to particularly high doses of ionizing radiation from diagnostic tests and procedures. Physicians caring for such @entity0 must seek to limit radiation exposure whenever possible to lessen the lifetime risk of @entity1 .

title: Pediatric XXXX and imaging-related radiation: are we increasing the likelihood of @entity1 ?

answer: @entity2


abstract: BACKGROUND AND AIMS: Increasing use of diagnostic radiography has led to concern about the malignant potential of ionizing radiation. We aimed to quantify the @entity6 ( @entity6 ) from diagnostic medical imaging in @entity0 with @entity2 ( @entity2 ) and to identify which @entity0 are at greatest risk for high amounts of image-related radiation exposure. @entity0 AND METHODS: A retrospective chart review of pediatric @entity2 @entity0 seen between January 1 and May 30, 2008 was conducted. The effective dose of radiation received from all of the radiology tests performed during the course of each @entity0 's treatment was estimated using typical effective doses and our institution's computed tomography dose index. A @entity6 >= 50 @entity5 was considered high. RESULTS: Complete records were available for 257 of 372 screened subjects. One hundred seventy-one had @entity3 ( @entity3 ) and 86 had @entity4 ( @entity4 ). The mean @entity6 was 17.56    15.91 @entity5 and was greater for @entity0 with @entity3 than for those with @entity4 (20.5    17.5 vs 11.7    9.9 @entity5 , P < 0.0001). Fifteen @entity0 (5.8%) had a @entity6 >= 50 @entity5 , including 14 of 171 (8.2%) with @entity3 and 1 of 86 (1.2%) with @entity4 (P = 0.02). In @entity0 with @entity3 , factors associated with high @entity6 per multivariate analysis were any @entity2 -related surgery (odds ratio 42, 95% confidence interval 8-223, P < 0.0001) and platelet count (odds ratio 16, 95% confidence interval 1.5-175, P = 0.02). CONCLUSIONS: Although all doses of ionizing radiation have some @entity1 -inducing potential, a small but important percentage of @entity0 with @entity2 are exposed to particularly high doses of ionizing radiation from diagnostic tests and procedures. Physicians caring for such @entity0 must seek to limit radiation exposure whenever possible to lessen the lifetime risk of @entity1 .

title: Pediatric @entity2 and imaging-related radiation: are we increasing the likelihood of XXXX ?

answer: @entity1


abstract: BACKGROUND: Several case-control studies have reported that @entity0 who use vaginal douche products are at increased risk for @entity3 . @entity0 who douche regularly may do so for reasons related to their risk of acquiring a @entity2 , introducing confounding that is difficult to control in non-experimental studies. METHODS: We conducted a multicenter randomized field trial with a 1-year follow-up period. The study comprised 1827 @entity0 age 18-34, with no current indication of @entity3 , who were regular users of a douche product and who had been treated recently for a sexually transmitted @entity1 . @entity0 were randomly assigned to use either a newly designed and marketed douche product or a soft cloth towelette, and were resupplied with product at each bimonthly follow-up visit. We measured the occurrence of @entity3 using a combination of clinical and laboratory indicators. We also recorded pregnancy occurrence among @entity0 . RESULTS: The risk of @entity4 among @entity0 assigned to use the douche product, relative to that among @entity0 assigned to use the wipe product, was 1.05 (95% confidence interval = 0.57-1.9). Using an alternative, less sensitive definition of @entity4 gave a risk ratio of 1.26 (0.62-2.6). The probability of becoming pregnant was 15% lower among @entity0 assigned to use a douche product, and 33% lower among @entity0 who douched more frequently (ratio = 0.67; 0.42-1.08). CONCLUSIONS: There was little or no indication of a greater risk of @entity4 among @entity0 assigned to use the douche product. Douching may be related to a lower probability that a @entity0 becomes pregnant.

title: Randomized field trial of vaginal douching, XXXX and pregnancy.

answer: @entity3


abstract: OBJECT: The posterior ligamentous complex (PLC) in the thoracic and lumbar spine is one of the region's important stabilizers. The precise diagnosis of @entity1 is required to evaluate the instability of the injured spine; however, the accuracy of magnetic resonance (MR) imaging for diagnosing @entity1 has remained unclear. In this study, the authors compared preoperative MR imaging findings with direct intraoperative observation of @entity1 , clarifying the former's diagnostic accuracy regarding detection of @entity1 associated with the @entity2 . METHODS: Data obtained in 35 @entity0 who sustained thoracic or lumbar injuries were reviewed. There were 17 burst @entity2 , six flexion-distraction injuries, and 12 @entity2 . Each @entity0 underwent MR imaging examination within 3 weeks of injury. Three radiologists independently evaluated sagittal MR images in a blinded fashion. The PLC-related information was retrospectively collected from each operative record. The diagnostic accuracy of MR imaging was analyzed by comparing imaging-documented intraoperative findings. The @entity1 were detected in 23 @entity0 (65.7%) by direct observation during posterior spinal procedures. The diagnostic accuracy of MR imaging in detecting injury of the supraspinous ligament (SSL) and interspinous ligament (ISL) was 90.5 and 94.3%, respectively. The specificity of T1-weighted MR imaging alone for depicting the SSL was significantly greater than T2-weighted imaging alone (p < 0.05). The overall mean kappa coefficient for MR imaging findings of @entity1 was 0.803, which indicated excellent interobserver reliability; that for ISL (0.915) was significantly greater than that for SSL (0.69) (p < 0.05). CONCLUSIONS: This study clarified a high diagnostic accuracy and interobserver reliability of MR imaging for @entity1 . The precise diagnosis of @entity1 is essential to determine the mechanical instability of the injured thoracic and lumbar spine, especially in differentiating unstable (three-column) burst @entity2 from the relatively stable (two-column) type. The authors conclude that MR imaging is a powerful diagnostic tool to evaluate @entity1 associated with @entity2 .

title: Diagnostic accuracy of magnetic resonance imaging for detecting posterior ligamentous complex injury associated with XXXX .

answer: @entity2


abstract: BACKGROUND AND AIMS: @entity9 is common in Pakistan and has an extremely poor prognosis. Treatment is primarily surgical. Chemotherapy is frequently used in @entity0 with @entity11 . This study was performed to evaluate and compare the clinicopathological features and management of @entity9 in @entity13 @entity0 , with particular emphasis on factors that influence survival. METHODS: Two hundred and thirty-three @entity0 with histologically proven @entity9 were studied. Information was prospectively collected on demographic features, clinical and laboratory findings at the time of presentation, influence of therapy, and survival. Data were analyzed to evaluate variables that influenced survival. Kaplan-Meier analysis was used to calculate survival. RESULTS: Most @entity0 were @entity0 (77%). Mean age was 55 years (+/-11 years). Fourteen per cent of females were nulliparous. Twenty-six per cent had five or more @entity0 . Only 4% of @entity0 had a documented history of @entity12 . The majority (69%) had a history of symptomatic @entity8 . The commonest presenting symptom was @entity3 (89%), followed by @entity6 and @entity7 (52%), @entity5 (42%), and @entity10 (33%). One-quarter of @entity0 had a palpable abdominal mass. Most had abnormal hepatic function tests and 58% had @entity4 embryonic antigen levels. Stage (P < 0.001), @entity10 (P = 0.01) and palpable mass (P = 0.02) were statistically significant variables. However, on multivariate analysis, @entity2 node @entity1 (TNM) stage was the only factor influencing survival. Median survival of the @entity0 was 44 months for @entity0 with stage I disease, 23 months for stage II, 17 months for stage III and 6 months for stage IV. CONCLUSION: These data are comparable with those reported from other developing countries. Most @entity0 presented at an advanced stage of disease and had an extremely poor prognosis. Systemic therapy did not provide any survival benefit. The TNM stage remains the most important factor influencing survival.

title: Clinicopathological features and management of XXXX in Pakistan: a prospective study of 233 cases.

answer: @entity9


abstract: The psychrotrophic organism @entity5 (Y.e.) is able to grow in foodstuffs thus rendering it dangerous for the consumer. Among others, the preparation of food in the kitchen might be an important way of transmission. Not only contaminated raw meat but aswell latently infected @entity0 and pet animals ( @entity4 , @entity2 ) may serve as a reservoir for Y.e. contamination. After artificial contamination of UHT milk and vanilla sauce with subsequent storage at 4 degrees C, two Y.e. strains of serovars 0:3 and 0:9 carrying the virulence plasmid multiplied during the first 6 d (9 d) at a rate of 1 log/d (Fig. 1). In pasteurized milk the multiplication rate was 0,65 log/d (Fig.2). Maximum bacterial counts in UHT milk after 15 d were in the order of 10(9) CFU/ml (Fig.4). In pasteurized milk, even minimal inoculation doses of less than 5 CFU/100ml (calculated) produced multiplication of Y.e. to 1,7-27 X 10(4) CFU/ml after 7 d (Tab.1). In this case the milk has been contaminated by an appropriately diluted suspension of faeces from infected @entity1 . When selected colonies were tested on MOX-Agar, a loss of the virulence plasmid could not be observed. In minced fresh pork meat with a bacterial count of 4,2 X 10(6) CFU/g--most of them i.e. 2,6 X 10(6) belonging to Pseudomonas sp.--added Y.e. did not multiply, but viable organisms could be recovered after contamination with only 2,9-6,6 X 10(2) CFU Y.e./g and storage at 4 degrees C for 72 h (Tab.2). Similarly, after contamination of quartered paprika husks and halves of @entity6 , Y.e. strains could be re-isolated after 15 d storage at 4 degrees C or room temperature if the number of bacteria used for inoculation was in the range of 10(6) (Tab.3). Feeding contaminated @entity6 to NMRI- @entity1 a calculated number of 5 X 10(3) CFU Y.e./ @entity1 were sufficient to cause @entity3 of part of the animals together with shedding of the organisms through the faeces (Tab.4). These results support the assumption that milk and home made milk products like vanilla sauce create a risk for @entity0 health when they are stored for a few days after contamination with Y.e. carrying the virulence plasmid. The same may be true for raw minced pork and fresh vegetables but only if the initial contamination was high. This might occur during food processing procedures.(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Growth rates of two virulence plasmids carrying XXXX after contamination of heated milk, raw minced pork and vegetables].

answer: @entity5


abstract: The role of microvascular damage in the genesis of the "no-reflow" phenomenon was investigated in the left ventricular myocardium of @entity3 subjected to temporary occlusions of a major coronary artery for 40 and 90 min. Intravenous @entity6 or @entity5 (a fluorescent vital stain for endothelium) were used to demonstrate the distribution of coronary arterial flow in control and damaged myocardium. These tracers were injected simultaneously with release of the @entity4 or after 5 or 20 min of reflow of coronary arterial blood. After 40 min of @entity1 plus arterial reperfusion, usually the tracers were evenly distributed throughout the damaged tissue at each time of reperfusion. On the other hand, when reflow was allowed after 90 min of @entity1 , portions of the inner half of damaged myocardium were not penetrated by the tracers. Electron microscopic study of this poorly perfused tissue revealed severe @entity0 ; endothelial cells with large intraluminal protrusions and decreased pinocytic vesicles were common. Also, occasional intraluminal fibrin thrombi were noted, as well as extravascular fibrin deposits and erythrocytes. Myocardial cells were swollen in both poorly perfused and well-perfused irreversibly injured tissue. Contraction bands and mitochondrial @entity2 accumulation were prominent features of irreversible injury with reflow at 40 min but were not noted after 90 min of @entity1 in areas with poor perfusion. These results suggest that 40 min of @entity1 were tolerated by the capillary bed of the @entity3 heart without serious @entity0 or perfusion defects, but that 90 min of @entity1 was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion. This failure of reflow was associated with extensive @entity0 and myocardial cell swelling. Death of severely @entity1 myocardial cells in this model occurs before the onset of @entity0 and the no-reflow phenomenon.

title: The "no-reflow" phenomenon after temporary XXXX in the @entity3 .

answer: @entity4


abstract: The role of microvascular damage in the genesis of the "no-reflow" phenomenon was investigated in the left ventricular myocardium of @entity3 subjected to temporary occlusions of a major coronary artery for 40 and 90 min. Intravenous @entity6 or @entity5 (a fluorescent vital stain for endothelium) were used to demonstrate the distribution of coronary arterial flow in control and damaged myocardium. These tracers were injected simultaneously with release of the @entity4 or after 5 or 20 min of reflow of coronary arterial blood. After 40 min of @entity1 plus arterial reperfusion, usually the tracers were evenly distributed throughout the damaged tissue at each time of reperfusion. On the other hand, when reflow was allowed after 90 min of @entity1 , portions of the inner half of damaged myocardium were not penetrated by the tracers. Electron microscopic study of this poorly perfused tissue revealed severe @entity0 ; endothelial cells with large intraluminal protrusions and decreased pinocytic vesicles were common. Also, occasional intraluminal fibrin thrombi were noted, as well as extravascular fibrin deposits and erythrocytes. Myocardial cells were swollen in both poorly perfused and well-perfused irreversibly injured tissue. Contraction bands and mitochondrial @entity2 accumulation were prominent features of irreversible injury with reflow at 40 min but were not noted after 90 min of @entity1 in areas with poor perfusion. These results suggest that 40 min of @entity1 were tolerated by the capillary bed of the @entity3 heart without serious @entity0 or perfusion defects, but that 90 min of @entity1 was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion. This failure of reflow was associated with extensive @entity0 and myocardial cell swelling. Death of severely @entity1 myocardial cells in this model occurs before the onset of @entity0 and the no-reflow phenomenon.

title: The "no-reflow" phenomenon after temporary @entity4 in the XXXX .

answer: @entity3


abstract: BACKGROUND: Hematological side effects are not generally expected due to radiotherapy involving limited radiation fields; however, @entity0 with @entity6 of the @entity2 (SCCH and N) receiving radiation therapy frequently have chronic @entity3 . @entity8 has been implicated as a cause of it, but local or systemic immune alterations are not usually considered. METHODS: With the purpose of evaluating the impact of radiotherapy treatment to different anatomic sites on immune function, 70 @entity0 were evaluated during and after radiotherapy: 50 cases with SCCH and N, 10 with @entity6 ( @entity6 ) and 10 @entity0 with @entity7 ( @entity7 ). We analyzed lymphocyte counts and T-cell subsets, and over time, their association with the presence of intracellular infections and disease-free survival. RESULTS: Severe @entity9 was observed in @entity0 with @entity6 and SCCH and N by the fifth week of treatment. @entity0 with @entity7 @entity1 developed mild @entity9 . In @entity0 with SCCH and N and UC, lower counts were seen in B cells and total T lymphocyte counts including both @entity4 (+) and @entity5 (+) cell subsets. The @entity0 with @entity6 recovered lymphocyte counts by the 24th month but T-cell subsets lagged behind. None of the SCCH and N @entity0 had fully recovered by 60 months of follow-up. Recurrence correlates with low lymphocyte counts. DISCUSSION: This work highlights the vulnerability of the @entity2 area to the impact of radiotherapy as a reservoir of lymphoid cells. The possibility of recovery as a consequence of thymopoiesis and/or peripheral clonal expansion may limit the antigen-specific recognition of relevant @entity1 or microbial antigens and cause significant and prolonged immune alterations that may impact long-term survival.

title: Long-term immune dysfunction after radiotherapy to the XXXX area.

answer: @entity2


abstract: INTRODUCTION: When @entity1 @entity0 express a wish for euthanasia, this should first and foremost be interpreted as a cry for help. Due to their close day-to-day relationship, @entity1 nurses may play an important and central role in responding to such requests. However, little is known about nurses' attitudes towards euthanasia motivated by @entity2 . OBJECTIVES: The aim of this study was to provide insight into the attitudes and actions taken by @entity1 nurses when confronted with a @entity0 's euthanasia request based on @entity2 ( @entity2 ). METHOD: A questionnaire was sent to 11 @entity1 hospitals in the Flemish part of Belgium. RESULTS: The overall response rate was 70% (N = 627). Psychiatric nurses were frequently confronted with a request for euthanasia, either directly (N = 329, 53%) or through a colleague (N = 427, 69%). A majority (N = 536, 84%) did not object to euthanasia in a psychiatrically ill population with @entity2 . Confounding factors were the @entity1 diagnosis and the type of ward where the nurses were working. Most @entity0 acknowledged a lack of knowledge and skills to adequately address the euthanasia request (N = 434, 71%). Nearly unanimously (N = 618, 99%), study @entity0 indicated that dealing with euthanasia requests and other end-of-life issues should be part of the formal training of nurses. CONCLUSION: The results highlight the need for ethically sound and comprehensive provision of care. Psychiatric nurses play an important role in dealing with the complex issue of requests for euthanasia. There is also a need for education, training and clear guidelines on the level of health care organizations.

title: Attitudes of Psychiatric Nurses about the Request for Euthanasia on the Basis of Unbearable Mental Suffering( XXXX ).

answer: @entity2


abstract: BACKGROUND: Previously described prognostic markers in @entity8 ( @entity8 ) include @entity1 size >= 1cm, fever for more than three weeks, @entity6 and severe @entity3 . This study aimed to evaluate effectiveness of medical therapy for vegetations >= 1cm and explore determinants of outcome in a representative population of intravenous drug users (IDUs) at a metropolitan Australian health service. METHODS: Retrospective review of consecutive IDUs presenting to our institution with native-valve @entity8 (by modified Duke criteria) over six years (2005-2011). Data recorded included echocardiographic estimation of maximal @entity1 diameter (classified as < or >= 1cm). Relationships between @entity1 size and specified outcomes of @entity2 , @entity4 , recurrence and relapse were examined by Chi-squared testing. RESULTS: Of 49 episodes five (10%) were managed surgically and a further four (8%) were lost to follow-up and excluded from the analysis. Of the remaining 40 evaluable medically treated @entity0 (median age 28, range 20-55), 37 (93%) cultured @entity9 -sensitive @entity7 and all had tricuspid valve involvement. Of 24 with vegetations >= 1cm, three died (mortality 13%) compared with one (6%) in 16 medically treated @entity0 with vegetations <1cm (p=0.63). A Pittsburgh (PITT) @entity5 score of >= 4 at presentation was associated with a mortality of 24% (four of 17 @entity0 died) compared with 0 in 23 @entity0 with PITT scores <4 (p=0.026). CONCLUSION: Medical therapy alone can be effective for @entity8 when large vegetations are present. However a high @entity3 score at presentation may increase risk of @entity2 . Larger studies are required to determine optimal indications for early surgical intervention.

title: A Retrospective Review: Significance of Vegetation Size in Injection Drug Users with Right-Sided XXXX .

answer: @entity8


abstract: The aim of this study was to provide quantitative descriptions of the dendritic branching patterns of pyramidal neurones in the @entity1 region of the @entity0 hippocampus. Thirteen adult cells were filled with biocytin and reconstructed by using the light microscope. The number of basal trees arising from the soma of each cell ranged from two to eight. There was wide variation in the number of terminal segments per tree. Six cells had single apical trunks, and seven had trunks that bifurcated in stratum radiatum. The number of apical oblique trees ranged from nine to 30, with each tree usually showing a lower degree of branching than basal trees. Basal and oblique trees had similar branching patterns, with the majority of branch points occurring close to the origin of the tree. Both basal and oblique terminal segments were generally much longer than intermediate segments and constituted up to 90% of the combined @entity2 of the tree. The branching pattern of the apical tuft was different, with many relatively long intermediate segments; terminal segments contributed only some 66% of the combined @entity2 of these trees. The mean total combined @entity2 for six adult cells reconstructed and measured completely was 11,900 +/- 1,000 microns (standard deviation). The relative proportions of the different parts of the dendritic system, although not the total @entity2 , were correlated with the location of the soma relative to the cell body layer. Cells with somata close to the stratum pyramidale/stratum radiatum border had more dendrites terminating in stratum radiatum and fewer in stratum oriens than cells with somata further from it.

title: Dendritic morphology of XXXX pyramidal neurones from the @entity0 hippocampus: I. Branching patterns.

answer: @entity1


abstract: The aim of this study was to provide quantitative descriptions of the dendritic branching patterns of pyramidal neurones in the @entity1 region of the @entity0 hippocampus. Thirteen adult cells were filled with biocytin and reconstructed by using the light microscope. The number of basal trees arising from the soma of each cell ranged from two to eight. There was wide variation in the number of terminal segments per tree. Six cells had single apical trunks, and seven had trunks that bifurcated in stratum radiatum. The number of apical oblique trees ranged from nine to 30, with each tree usually showing a lower degree of branching than basal trees. Basal and oblique trees had similar branching patterns, with the majority of branch points occurring close to the origin of the tree. Both basal and oblique terminal segments were generally much longer than intermediate segments and constituted up to 90% of the combined @entity2 of the tree. The branching pattern of the apical tuft was different, with many relatively long intermediate segments; terminal segments contributed only some 66% of the combined @entity2 of these trees. The mean total combined @entity2 for six adult cells reconstructed and measured completely was 11,900 +/- 1,000 microns (standard deviation). The relative proportions of the different parts of the dendritic system, although not the total @entity2 , were correlated with the location of the soma relative to the cell body layer. Cells with somata close to the stratum pyramidale/stratum radiatum border had more dendrites terminating in stratum radiatum and fewer in stratum oriens than cells with somata further from it.

title: Dendritic morphology of @entity1 pyramidal neurones from the XXXX hippocampus: I. Branching patterns.

answer: @entity0


abstract: OBJECTIVE: To compare long-term patency after @entity1 ( @entity1 ) for superficial femoral artery (SFA) occlusive disease between @entity0 with hemodialysis ( @entity3 ; @entity3 +) and those without @entity3 ( @entity3 -). BACKGROUND: Long-term patency after @entity1 for @entity2 in @entity3 + remains unknown. METHODS: @entity1 to SFA was successfully performed in 382 consecutive @entity0 during 2004-2011. Cox proportional hazard model estimated the hazard ratio (HR) for the loss of primary patency (PP), secondary patency (SP), and @entity4 ( @entity4 ) in @entity3 +. Binominal logistic regression analysis calculated the propensity score (PS) for covariates with a P value of <0.2 for @entity3 as a dependent variable. HRs were adjusted for PS in multivariate analysis using the Cox proportional hazard model. RESULTS: PP and SP in @entity3 + and @entity3 - were 47.9 and 79.4% and 68.4 and 92.5%, respectively, 4 years after @entity1 . There were no procedure-related amputations or in-hospital deaths. Adjusted HRs for the loss of PP, SP, and @entity4 were as follows: loss of PP, adjusted HR 2.010, 95% CI 1.157-3.492, P   =   0.013; loss of SP, adjusted HR 2.927, 95% CI 1.236-6.933, P   =   0.015; and loss of @entity4 , adjusted HR 1.665, 95% CI 0.994-2.791, P   =   0.053. CONCLUSIONS: Although @entity3 + had more than double the risks for loss of PP and SP than @entity3 -, @entity1 to SFA in @entity3 + was found to be safe with an acceptable PP and SP.    2015 Wiley Periodicals, Inc.

title: Comparison of long-term patency after XXXX for superficial femoral artery occlusive disease between @entity0 with and without hemodialysis.

answer: @entity1


abstract: OBJECTIVE: To compare long-term patency after @entity1 ( @entity1 ) for superficial femoral artery (SFA) occlusive disease between @entity0 with hemodialysis ( @entity3 ; @entity3 +) and those without @entity3 ( @entity3 -). BACKGROUND: Long-term patency after @entity1 for @entity2 in @entity3 + remains unknown. METHODS: @entity1 to SFA was successfully performed in 382 consecutive @entity0 during 2004-2011. Cox proportional hazard model estimated the hazard ratio (HR) for the loss of primary patency (PP), secondary patency (SP), and @entity4 ( @entity4 ) in @entity3 +. Binominal logistic regression analysis calculated the propensity score (PS) for covariates with a P value of <0.2 for @entity3 as a dependent variable. HRs were adjusted for PS in multivariate analysis using the Cox proportional hazard model. RESULTS: PP and SP in @entity3 + and @entity3 - were 47.9 and 79.4% and 68.4 and 92.5%, respectively, 4 years after @entity1 . There were no procedure-related amputations or in-hospital deaths. Adjusted HRs for the loss of PP, SP, and @entity4 were as follows: loss of PP, adjusted HR 2.010, 95% CI 1.157-3.492, P   =   0.013; loss of SP, adjusted HR 2.927, 95% CI 1.236-6.933, P   =   0.015; and loss of @entity4 , adjusted HR 1.665, 95% CI 0.994-2.791, P   =   0.053. CONCLUSIONS: Although @entity3 + had more than double the risks for loss of PP and SP than @entity3 -, @entity1 to SFA in @entity3 + was found to be safe with an acceptable PP and SP.    2015 Wiley Periodicals, Inc.

title: Comparison of long-term patency after @entity1 for superficial femoral artery occlusive disease between XXXX with and without hemodialysis.

answer: @entity0


abstract: BACKGROUND: Right ventricular (RV) dysfunction has been associated with poor prognosis in @entity2 ( @entity2 ). However, less data is available about the role of @entity1 in @entity0 with cardiac resynchronization therapy (CRT). We aimed to investigate if @entity1 would predict outcome in CRT. DESIGN: We enrolled prospectively ninety-three consecutive @entity2 @entity0 in this single center observational study. All @entity0 underwent clinical evaluation and echocardiography before CRT and 6 months after implantation. We assessed RV geometry and function by using speckle tracking imaging and calculated strain parameters. We performed multivariable Cox regression models to test mortality at 6 months and at 24 months. RESULTS: @entity1 , characterized by decreased @entity3 ( @entity3 ) [10.2 (7.0-12.8) vs. 19.5 (15.0-23.9) %, p<0.0001] and @entity4 ( @entity4 ) [15.6 (10.0-19.3) vs. 17.4 (10.5-22.2) %, p = 0.04], improved 6 months after CRT implantation. Increasing baseline @entity3 and @entity4 predicted survival independent of other parameters at 6 months [hazard ratio (HR) = 0.37 (0.15-0.90), p = 0.02 and HR = 0.42 (0.19-0.89), p = 0.02; per 1 standard deviation increase, respectively]. @entity3 proved to be a significant independent predictor of mortality at 24 months [HR = 0.53 (0.32-0.86), p = 0.01], and @entity4 showed a strong tendency [HR = 0.64 (0.40-1.00), p = 0.05]. The 24-month survival was significantly impaired in @entity0 with @entity3 below 10.04% before CRT implantation [area under the curve = 0.72 (0.60-0.84), p = 0.002, log-rank p = 0.0008; HR = 5.23 (1.76-15.48), p = 0.003]. CONCLUSIONS: Our findings indicate that baseline @entity1 is associated with poor short-term and long-term prognosis after CRT implantation.

title: Role of Right XXXX in Predicting Early and Long-Term Mortality in Cardiac Resynchronization Therapy @entity0 .

answer: @entity1


abstract: BACKGROUND: Right ventricular (RV) dysfunction has been associated with poor prognosis in @entity2 ( @entity2 ). However, less data is available about the role of @entity1 in @entity0 with cardiac resynchronization therapy (CRT). We aimed to investigate if @entity1 would predict outcome in CRT. DESIGN: We enrolled prospectively ninety-three consecutive @entity2 @entity0 in this single center observational study. All @entity0 underwent clinical evaluation and echocardiography before CRT and 6 months after implantation. We assessed RV geometry and function by using speckle tracking imaging and calculated strain parameters. We performed multivariable Cox regression models to test mortality at 6 months and at 24 months. RESULTS: @entity1 , characterized by decreased @entity3 ( @entity3 ) [10.2 (7.0-12.8) vs. 19.5 (15.0-23.9) %, p<0.0001] and @entity4 ( @entity4 ) [15.6 (10.0-19.3) vs. 17.4 (10.5-22.2) %, p = 0.04], improved 6 months after CRT implantation. Increasing baseline @entity3 and @entity4 predicted survival independent of other parameters at 6 months [hazard ratio (HR) = 0.37 (0.15-0.90), p = 0.02 and HR = 0.42 (0.19-0.89), p = 0.02; per 1 standard deviation increase, respectively]. @entity3 proved to be a significant independent predictor of mortality at 24 months [HR = 0.53 (0.32-0.86), p = 0.01], and @entity4 showed a strong tendency [HR = 0.64 (0.40-1.00), p = 0.05]. The 24-month survival was significantly impaired in @entity0 with @entity3 below 10.04% before CRT implantation [area under the curve = 0.72 (0.60-0.84), p = 0.002, log-rank p = 0.0008; HR = 5.23 (1.76-15.48), p = 0.003]. CONCLUSIONS: Our findings indicate that baseline @entity1 is associated with poor short-term and long-term prognosis after CRT implantation.

title: Role of Right @entity1 in Predicting Early and Long-Term Mortality in Cardiac Resynchronization Therapy XXXX .

answer: @entity0


abstract: BACKGROUND: Thyrotropin (TSH)-suppressive doses of @entity3 ( @entity4 ) have adverse effects on bone and cardiac function, but it is unclear whether metabolic function is also affected. The objective of this study was to determine whether @entity0 receiving TSH-suppressive @entity4 doses have alterations in energy expenditure or body composition. METHODS: This study was a cross-sectional comparison between three groups of @entity0 : 26 @entity0 receiving chronic TSH-suppressive @entity4 doses, 80 @entity0 receiving chronic replacement @entity4 doses, and 16 untreated euthyroid control @entity0 . Subjects underwent measurements of resting energy expenditure (REE), substrate oxidation, and thermic effect of food by indirect calorimetry; physical activity energy expenditure by accelerometer; caloric intake by 24-hour diet recall; and body composition by dual X-ray absorptiometry. RESULTS: REE per kilogram lean body mass in the @entity4 euthyroid @entity0 was 6% lower than that of the @entity4 -suppressed group, and 4% lower than that of the healthy control group (p   =   0.04). Free @entity2 (fT3) levels were directly correlated with REE, and were 10% lower in the @entity4 euthyroid @entity0 compared with the other two groups (p   =   0.007). The groups of subjects did not differ in other measures of energy expenditure, caloric intake, or body composition. CONCLUSIONS: @entity4 suppression therapy does not adversely affect energy expenditure or body composition in @entity0 . However, @entity4 replacement therapy is associated with a lower REE, despite TSH levels within the reference range. This may be due to lower fT3 levels, suggesting relative tissue @entity1 may contribute to impaired energy expenditure in @entity4 therapy.

title: Effects of XXXX Replacement or Suppressive Therapy on Energy Expenditure and Body Composition.

answer: @entity3


abstract: BACKGROUND: Polio infection can often lead to orthopedic complications such as @entity5 , @entity3 , @entity4 , @entity1 , and chronic instability of the joints. The purpose of this study was to assess the outcomes and associated complications of arthroplasty in shoulders with sequelae of @entity7 . METHODS: Seven @entity0 (average age, 70 years) were treated between 1976 and 2013 with shoulder arthroplasty for the sequelae of polio. One @entity0 underwent reverse shoulder arthroplasty, 2 had a hemiarthroplasty, and 4 had total shoulder arthroplasty. Average follow-up was 87  months. Outcome measures included @entity2 , range of motion, and postoperative modified Neer ratings. RESULTS: Overall @entity2 scores improved from 5 to 1.6 points (on a 5-point scale) after shoulder arthroplasty. Six shoulders had no or mild @entity2 at latest follow-up, and 6 shoulders rated the result as much better or better. Mean shoulder elevation improved from 72   to 129  , and external rotation improved from 11   to 56  . Average strength in elevation decreased from 3.9 to 3.4 postoperatively, and external rotation strength decreased from 3.9 to 3.3. This, however, did not reach significance. Evidence of muscle imbalance with radiographic instability was found in 4 shoulders that demonstrated superior subluxation, anterior subluxation, or both. This remained asymptomatic. No shoulder required revision or reoperation. CONCLUSIONS: Shoulder arthroplasty provides significant @entity2 relief and improved motion in @entity0 with sequelae of @entity7 . @entity4 may be responsible for postoperative instability, and careful selection of the @entity0 with @entity6 muscles must be made.

title: Shoulder arthroplasty for sequelae of XXXX .

answer: @entity7


abstract: UNASSIGNED: The aim of this population-based study was to identify demographic factors for @entity1 at an early age. The risk analysis covered 11 biological and 8 environmental factors. The mothers' concerns regarding language development were also examined. A total of 226 @entity0 from a Finnish cohort study were invited to participate in language assessments at 36 months. The test results for word finding and language comprehension were compared with parental questionnaires about @entity0 's vocabulary at 13 and 24 months. Regression analysis revealed that the father's social class (t=-2.79, p=0.006) and working full time (t=-2.86, p=0.005) significantly predicted @entity0 's @entity1 . In addition, language comprehension was significantly predicted by the mother's social class (t=-2.06, p=0.041) and by gender, with an advantage to @entity0 (t=-2.71, p=0.008). Vocabulary at 24 months was a powerful predictor for lexical development (t=4.58, p<0.0001) and language comprehension (t=4.85, p<0.0001) at 36 months. Mothers' concerns were correlated with @entity0 's limited lexicons as early as 24 months (r=0.31, p<0.0001) and poor language comprehension (r=-0.35, p<0.0001) at 36 months. Mothers were especially concerned if the parents needed special education during school years. At the population-level, gender was the most powerful biological factor in predicting @entity1 . Similarly, both parents' social status had predictive value for the @entity0 's language development. In addition, it was found that the mother's concern about her @entity0 's slow language acquisition should be taken into account when making decisions regarding special support.

title: Identification of biological and environmental risk factors for XXXX : The Let's Talk STEPS study.

answer: @entity1


abstract: PURPOSE: Because a combination of @entity5 , interferon-alpha, and radiation therapy demonstrated synergistic action and effectiveness to treat @entity1 in earlier studies, we designed this randomized phase 2 open-label trial to assess efficacy and safety of @entity7 ( @entity6 ) and @entity8 (RA) administered concomitantly with radiation therapy ( @entity6 -RA-radiation) to treat @entity1 . METHODS AND MATERIALS: Stage III cervical @entity1 @entity0 were randomized to study and control groups in a 1:1 ratio. All @entity0 were treated with radiation therapy; study arm @entity0 received @entity6 (3  *  10(6) IU subcutaneously) 3 times a week for 4  weeks and daily RA (40  mg orally) for 30  days starting on day 1 of radiation, whereas control arm @entity0 received weekly @entity4 (40  mg/m(2)) for 5  weeks during radiation. @entity0 were followed for 3  years. The primary endpoint was overall survival at 3  years. RESULTS: @entity0 in the study (n=104) and control (n=105) groups were comparable for clinicopathological characteristics, radiation therapy-related variables and treatment response. Proportions of disease-free @entity0 in the study and control groups were 38.5% and 44.8%, respectively, after median follow-up of 29.2  months. Hazard ratios were 0.67 (95% confidence interval [CI]: 0.44-1.01) and 0.69 (95% CI: 0.44-1.06) for overall and disease-fee survival, respectively, comparing the study group to control, and demonstrated an inferior outcome with RA- @entity6 -radiation, although differences were statistically nonsignificant. Kaplan-Meier curves of disease-free and overall survival probabilities also showed inferior survival in the study group compared to those in the control. Acute @entity2 of chemoradiation were significantly higher with 2 acute @entity2 -related @entity3 . CONCLUSIONS: Treatment with RA- @entity6 -radiation did not demonstrate survival advantage over chemoradiation despite being less toxic. The trends predicted an inferior outcome with the RA- @entity6 combination.

title: Phase 2 Randomized Controlled Trial of Radiation Therapy Plus Concurrent Interferon-Alpha and @entity5 Versus XXXX for @entity1 .

answer: @entity4


abstract: PURPOSE: Because a combination of @entity5 , interferon-alpha, and radiation therapy demonstrated synergistic action and effectiveness to treat @entity1 in earlier studies, we designed this randomized phase 2 open-label trial to assess efficacy and safety of @entity7 ( @entity6 ) and @entity8 (RA) administered concomitantly with radiation therapy ( @entity6 -RA-radiation) to treat @entity1 . METHODS AND MATERIALS: Stage III cervical @entity1 @entity0 were randomized to study and control groups in a 1:1 ratio. All @entity0 were treated with radiation therapy; study arm @entity0 received @entity6 (3  *  10(6) IU subcutaneously) 3 times a week for 4  weeks and daily RA (40  mg orally) for 30  days starting on day 1 of radiation, whereas control arm @entity0 received weekly @entity4 (40  mg/m(2)) for 5  weeks during radiation. @entity0 were followed for 3  years. The primary endpoint was overall survival at 3  years. RESULTS: @entity0 in the study (n=104) and control (n=105) groups were comparable for clinicopathological characteristics, radiation therapy-related variables and treatment response. Proportions of disease-free @entity0 in the study and control groups were 38.5% and 44.8%, respectively, after median follow-up of 29.2  months. Hazard ratios were 0.67 (95% confidence interval [CI]: 0.44-1.01) and 0.69 (95% CI: 0.44-1.06) for overall and disease-fee survival, respectively, comparing the study group to control, and demonstrated an inferior outcome with RA- @entity6 -radiation, although differences were statistically nonsignificant. Kaplan-Meier curves of disease-free and overall survival probabilities also showed inferior survival in the study group compared to those in the control. Acute @entity2 of chemoradiation were significantly higher with 2 acute @entity2 -related @entity3 . CONCLUSIONS: Treatment with RA- @entity6 -radiation did not demonstrate survival advantage over chemoradiation despite being less toxic. The trends predicted an inferior outcome with the RA- @entity6 combination.

title: Phase 2 Randomized Controlled Trial of Radiation Therapy Plus Concurrent Interferon-Alpha and XXXX Versus @entity4 for @entity1 .

answer: @entity5


abstract: PURPOSE: Because a combination of @entity5 , interferon-alpha, and radiation therapy demonstrated synergistic action and effectiveness to treat @entity1 in earlier studies, we designed this randomized phase 2 open-label trial to assess efficacy and safety of @entity7 ( @entity6 ) and @entity8 (RA) administered concomitantly with radiation therapy ( @entity6 -RA-radiation) to treat @entity1 . METHODS AND MATERIALS: Stage III cervical @entity1 @entity0 were randomized to study and control groups in a 1:1 ratio. All @entity0 were treated with radiation therapy; study arm @entity0 received @entity6 (3  *  10(6) IU subcutaneously) 3 times a week for 4  weeks and daily RA (40  mg orally) for 30  days starting on day 1 of radiation, whereas control arm @entity0 received weekly @entity4 (40  mg/m(2)) for 5  weeks during radiation. @entity0 were followed for 3  years. The primary endpoint was overall survival at 3  years. RESULTS: @entity0 in the study (n=104) and control (n=105) groups were comparable for clinicopathological characteristics, radiation therapy-related variables and treatment response. Proportions of disease-free @entity0 in the study and control groups were 38.5% and 44.8%, respectively, after median follow-up of 29.2  months. Hazard ratios were 0.67 (95% confidence interval [CI]: 0.44-1.01) and 0.69 (95% CI: 0.44-1.06) for overall and disease-fee survival, respectively, comparing the study group to control, and demonstrated an inferior outcome with RA- @entity6 -radiation, although differences were statistically nonsignificant. Kaplan-Meier curves of disease-free and overall survival probabilities also showed inferior survival in the study group compared to those in the control. Acute @entity2 of chemoradiation were significantly higher with 2 acute @entity2 -related @entity3 . CONCLUSIONS: Treatment with RA- @entity6 -radiation did not demonstrate survival advantage over chemoradiation despite being less toxic. The trends predicted an inferior outcome with the RA- @entity6 combination.

title: Phase 2 Randomized Controlled Trial of Radiation Therapy Plus Concurrent Interferon-Alpha and @entity5 Versus @entity4 for XXXX .

answer: @entity1


abstract: Acute @entity5 was induced in @entity3 by perfusing activated pancreatic enzymes through their pancreatic ducts. The ducts had been made permeable to large molecules by one of two techniques. The @entity3 either received @entity6 (2 ml/kg every 8 h) and @entity2 (25 mg/kg every 8 h) orally for 48 h or had their pancreatic ducts perfused for 1 h with 7.5 mM @entity10 . When the same procedure was followed, but using @entity9 (dmPGE2) (2 micrograms/kg X h infused intravenously for 1 h before and during ductal perfusion with activated enzymes), @entity4 developed instead. To investigate whether an increase in pancreatic blood flow or microvascular permeability (both caused by dmPGE2) was important in this phenomenon, we tested the effects of @entity8 (which increased blood flow) and @entity1 (which increased microvascular permeability) in the model. Thus in similar experiments, either @entity8 (0.3 micrograms/kg . min) or @entity11 (2 micrograms/kg . min) was infused instead of dmPGE2. The animals that received @entity1 also developed @entity4 . Those that received @entity8 did not. These observations suggested that an increase in microvascular permeability in the pancreas converted @entity5 to @entity4 . These findings suggest also that clinical studies using @entity7 to treat @entity0 with @entity5 should be approached with caution.

title: A model of @entity4 in @entity3 --role of XXXX .

answer: @entity9


abstract: Acute @entity5 was induced in @entity3 by perfusing activated pancreatic enzymes through their pancreatic ducts. The ducts had been made permeable to large molecules by one of two techniques. The @entity3 either received @entity6 (2 ml/kg every 8 h) and @entity2 (25 mg/kg every 8 h) orally for 48 h or had their pancreatic ducts perfused for 1 h with 7.5 mM @entity10 . When the same procedure was followed, but using @entity9 (dmPGE2) (2 micrograms/kg X h infused intravenously for 1 h before and during ductal perfusion with activated enzymes), @entity4 developed instead. To investigate whether an increase in pancreatic blood flow or microvascular permeability (both caused by dmPGE2) was important in this phenomenon, we tested the effects of @entity8 (which increased blood flow) and @entity1 (which increased microvascular permeability) in the model. Thus in similar experiments, either @entity8 (0.3 micrograms/kg . min) or @entity11 (2 micrograms/kg . min) was infused instead of dmPGE2. The animals that received @entity1 also developed @entity4 . Those that received @entity8 did not. These observations suggested that an increase in microvascular permeability in the pancreas converted @entity5 to @entity4 . These findings suggest also that clinical studies using @entity7 to treat @entity0 with @entity5 should be approached with caution.

title: A model of XXXX in @entity3 --role of @entity9 .

answer: @entity4


abstract: Acute @entity5 was induced in @entity3 by perfusing activated pancreatic enzymes through their pancreatic ducts. The ducts had been made permeable to large molecules by one of two techniques. The @entity3 either received @entity6 (2 ml/kg every 8 h) and @entity2 (25 mg/kg every 8 h) orally for 48 h or had their pancreatic ducts perfused for 1 h with 7.5 mM @entity10 . When the same procedure was followed, but using @entity9 (dmPGE2) (2 micrograms/kg X h infused intravenously for 1 h before and during ductal perfusion with activated enzymes), @entity4 developed instead. To investigate whether an increase in pancreatic blood flow or microvascular permeability (both caused by dmPGE2) was important in this phenomenon, we tested the effects of @entity8 (which increased blood flow) and @entity1 (which increased microvascular permeability) in the model. Thus in similar experiments, either @entity8 (0.3 micrograms/kg . min) or @entity11 (2 micrograms/kg . min) was infused instead of dmPGE2. The animals that received @entity1 also developed @entity4 . Those that received @entity8 did not. These observations suggested that an increase in microvascular permeability in the pancreas converted @entity5 to @entity4 . These findings suggest also that clinical studies using @entity7 to treat @entity0 with @entity5 should be approached with caution.

title: A model of @entity4 in XXXX --role of @entity9 .

answer: @entity3