abstract: UNASSIGNED: Sea level rise will change inundation regimes in salt marshes, altering redox dynamics that control nitrification-a potential source of the potent greenhouse gas, @entity5 ( @entity4 )-and denitrification, a major @entity3 (N) loss pathway in coastal ecosystems and both a source and sink of @entity4 . Measurements of net @entity4 fluxes alone yield little insight into the different effects of redox conditions on @entity4 production and consumption. We used in situ measurements of gross @entity4 fluxes across a salt marsh elevation gradient to determine how soil @entity4 emissions in coastal ecosystems may respond to future sea level rise. Soil redox declined as marsh elevation decreased, with lower soil @entity2 and higher ferrous @entity1 in the low marsh compared to the mid and high marshes (p < 0.001 for both). In addition, soil @entity0 concentrations were lower in the low and mid marshes relative to the high marsh (p < 0.001). Net @entity4 fluxes differed significantly among marsh zones (p = 0.009), averaging 9.8    5.4  g N m(-2) h(-1) , -2.2    0.9  g N m(-2) h(-1) , and 0.67    0.57  g N m(-2) h(-1) in the low, mid, and high marshes, respectively. Both net @entity4 release and uptake were observed in the low and high marshes, but the mid marsh was consistently a net @entity4 sink. Gross @entity4 production was highest in the low marsh and lowest in the mid marsh (p = 0.02), whereas gross @entity4 consumption did not differ among marsh zones. Thus, variability in gross @entity4 production rates drove the differences in net @entity4 flux among marsh zones. Our results suggest that future studies should focus on elucidating controls on the processes producing, rather than consuming, @entity4 in salt marshes to improve our predictions of changes in net @entity4 fluxes caused by future sea level rise. This article is protected by copyright. All rights reserved.

title: Gross @entity5 production drives net XXXX fluxes across a salt marsh landscape.

answer: @entity5


abstract: OBJECTIVE: Physical activity interventions have been shown to improve the health of @entity0 with @entity3 , yet treatment dropout poses an important challenge in this population, and rates vary substantially across studies. We conducted a meta-analysis to investigate the prevalence and predictors of treatment dropout in physical activity interventions in @entity0 with @entity3 . METHOD: We systematically searched major electronic databases from inception until August 2015. Randomized controlled trials of physical activity interventions in @entity0 with @entity3 reporting dropout rates were included. Two independent authors conducted searches and extracted data. Random-effects meta-analysis and meta-regression analyses were conducted. RESULTS: In 19 studies, 594 @entity0 with @entity3 assigned to exercise interventions were investigated (age=37.2 years, 67.5% male, range=37.5%-100%). Trim and fill adjusted treatment dropout rate was 26.7% [95% confidence interval (CI)=19.7%-35.0%], which is more than double than in nonactive control interventions (odds ratio=2.15, 95% CI=1.29-3.58, P=.003). In the multivariate regression, qualification of the professional delivering the intervention (b=-1.06, 95% CI=-1.77 to -0.35, P=.003) moderated treatment dropout rates, while continuous supervision of physical activity approached statistical significance (P=.05). CONCLUSIONS: Qualified professionals (e.g., physical therapists/exercise physiologists) should prescribe supervised physical activity for @entity0 with @entity3 to enhance adherence, improve @entity2 symptoms and reduce the onset and burden of @entity1 .

title: Prevalence and predictors of treatment dropout from physical activity interventions in XXXX : a meta-analysis.

answer: @entity3


abstract: The interaction between @entity0 serosal mast cells and low density lipoproteins (LDL) was studied in vitro. When @entity0 125I-LDL was incubated with mast cells, it was bound to a binding site on the mast cell surface but was not internalized by the cells. Even though 125I-LDL was not internalized, its protein component, @entity2 , was rapidly degraded. The proteolytic activity responsible for the degradation of @entity2 was present in the extracellular fluid of mast cells. It could be shown that the degradation was caused entirely by specific cell organelles of mast cells, the granules, which were spontaneously released into the extracellular fluid during preparation and incubation of the cells. In contrast to uncontrolled spontaneous degranulation, a controlled specific degranulation of mast cells can be induced by treating the cells with the compound 48/80. When increasing amounts of 48/80 were added to mast cell suspensions, a dose-dependent release of granules was observed and an increase in the rate of 125I-LDL degradation resulted. The increase in 125I-LDL degradation closely followed the increase in granule release. Thus, a quantitative relationship between the amount of granules present in the extracellular fluid and the amount of degradation of 125I-LDL could be established. The apolipoprotein part of LDL was extensively degraded by isolated mast cell granules. Analysis by @entity1 gel electrophoresis showed that upon incubation of LDL with isolated granules, the @entity2 band rapidly disappeared with simultaneous appearance of several low molecular weight bands. The degradation of 125I-LDL by mast cell granules proceeded optimally at neutral pH and at physiological ionic strength. The results show that mast cell granules are able to efficiently degrade LDL in vitro, once released from mast cells into the extracellular fluid.

title: Low density lipoprotein degradation by XXXX mast cells. Demonstration of extracellular proteolysis caused by mast cell granules.

answer: @entity0


abstract: PROBLEM: The need to develop a @entity0 pathway for emergency admissions who have a previously undiagnosed @entity1 . DESIGN: The existing @entity0 pathway was audited and process-mapped to identify delays and areas for improvement. Discussions with key stakeholders were held to identify their needs from an acute oncology service. STRATEGIES FOR CHANGE: A new @entity0 pathway was developed, and a new online referral process was implemented. The publicity and education campaign was repeatedly aimed at referring physicians at consultant and junior level, and took the form of emails and presentations with handouts at all teaching sessions, multidisciplinary team meetings, the Consultants Committee and Junior Doctors' induction. Effects of change The new system was piloted for 6 months. 12/18 @entity0 were referred via the new pathway. 15/18 @entity0 were referred via the new online system. Length of stay, endoscopies, biopsies and blood tests were all statistically significantly reduced during the study period compared with the original audit. LESSONS LEARNT: The challenge was to convince the referring general physicians to use the new @entity0 pathway and referral method. Incorporating their ideas for improvement and implementation made it more likely that they would take up the new ideas. Education and publicity were also extensive, often repeated, and at both junior and senior level. Having the Lead Cancer Clinician and Acute Medicine Consultant engage directly with consultant colleagues, as well as strong support from the Medical Director, was also crucial to the project's success.

title: Towards saving a million bed days: reducing length of stay through an acute oncology model of care for inpatients diagnosed as having XXXX .

answer: @entity1


abstract: BACKGROUND: Transfusion of blood products occurs frequently in @entity2 surgery (rAAA). The aim of this study is to establish the impact of packed red blood cell (PRBC), fresh frozen plasma (FFP), and platelet (PLT) transfusion on the 30-day mortality and morbidity ( @entity1 versus non @entity1 ) of rAAAs. METHODS: A retrospective study of 90 consecutive rAAAs from November 2007 to June 2015 was conducted. Multivariable regression models were produced to determine blood products associated with 30-day morbidity and mortality post-rAAA. RESULTS: The overall mortality was 14.6%. At multivariable analyses, transfusion with FFP (>3 units) was independently associated with an increased risk of mortality (odds ratio [OR]: 11.27, 95% confidence interval [CI]: 1.13-96.72, P = .027). The overall morbidity was 26.8%, and subgroup analysis ( @entity1 ) demonstrated transfusion of PLTs (>1 pool) to be independently associated with @entity1 events (OR: 4.3, 95% CI: 1.37-13.6, P = .012). @entity1 events were responsible for 50% (n = 11 of 22) of all morbidities and mortalities (n = 6 of 12). CONCLUSION: Transfusion of FFP and PLTs may be associated with an increased risk of postoperative morbidity and mortality. The use of these blood components should be considered in the context of the @entity0 's clinical and laboratory data as opposed to a fixed ratio to PRBCs. This may result in the reduction in @entity1 emerging in rAAA cohort.

title: The Clinical Implication of Blood Product Transfusion on Morbidity and Mortality of XXXX .

answer: @entity2


abstract: PURPOSE: To describe the history and clinical presentation of a case of primary epibulbar molluscum contagiosum in @entity4 , after penetrating keratoplasty. METHODS: A 70-year-old @entity0 , with previously diagnosed @entity4 and @entity2 and @entity5 , presented 6 months after right penetrating keratoplasty with white multilobular nodules of the right limbus. No @entity1 were evident. Evaluation consisted of slit-lamp examination, and an excisional biopsy of the involved conjunctival epithelium was carried out with local cryotherapy. Excised tissue was sent for histopathologic studies. RESULTS: Slit-lamp examination revealed the presence of eight, 1-3 mm nodules of the perilimbal conjunctiva. In addition, there were opaque plaques at the level of the corneal epithelium. Mild perilesional conjunctival injection was evident, but there was no follicular conjunctival reaction. Histopathologic study of the lesions revealed eosinophilic intracytoplasmic inclusions (molluscum bodies) within the epithelial tissue. CONCLUSIONS: There are no other reports of primary epibulbar molluscum, without previous cutaneous lesions, in immunocompromised @entity0 without @entity3 or after keratoplasty. This diagnosis should be included in the differential of focal thickening of the conjunctival epithelium, and potentially the corneal epithelium, in immunosuppressed @entity0 .

title: Epibulbar molluscum contagiosum lesions in XXXX .

answer: @entity4


abstract: BACKGROUND: Limited information is available regarding dermatoscopic differences between @entity1 (BCC). OBJECTIVE: To investigate dermatoscopic differences between non-aggressive and aggressive types. METHODS: We evaluated 145 histopathologically confirmed BCCs from 141 @entity0 . Histopathologic types and @entity1 from 4 mm punch biopsy and their dermatoscopic findings were evaluated. We assessed the statistical significance of dermatoscopic differences between non-aggressive and aggressive types. To objectively predict @entity1 , we created a "dermatoscopic index of @entity2 " in which 1 point was added and subtracted for each dermatoscopic finding significantly higher in aggressive and non-aggressive types, respectively. RESULTS: Large blue-gray ovoid nests were found more frequently in non-aggressive type than aggressive one (85/105 [80.9%] vs. 21/40 [52.5%], p=0.001). Compared to non-aggressive type, aggressive type had more multiple blue-gray globules (29/40 [72.5%] vs. 57/105 [54.3%], p=0.046), arborizing @entity3 (29/40 [72.5%] vs. 48/105 [45.7%], p=0.004), and concentric structure (11/40 [27.5%] vs. 12/105 [11.4%], p=0.018). Regarding dermatoscopic index, cases of aggressive type with a score of 1 were most common (n=18, 45.0%), followed by a score of 2 (n=14, 35.0%). Limited number of aggressive type of BCCs and the effect of width on the determination of histopathologic @entity1 . CONCLUSION: Aggressive type BCCs more often exhibited multiple blue-gray globules, arborizing @entity3 , and concentric structure, while the non-aggressive type exhibited large blue-gray ovoid nests more frequently. Score exceeding 2 on the dermoscopic index can be screening criteria for @entity1 . These dermatoscopic features and dermoscopic index could be useful for assessing @entity1 of BCCs before surgery.

title: Usefulness of Dermatoscopy for the Preoperative Assessment of the Histopathologic XXXX .

answer: @entity2


abstract: BACKGROUND: The filamentous fungus @entity4 (anamorph of @entity4 ) produces increased cellulase expression when grown on cellulose or its derivatives as a sole @entity1 source. It has been believed that b-glucosidases of @entity4 not only metabolize @entity3 but also contribute in the production of inducers of cellulase gene expression by their transglycosylation activity. The cellulase hyper-producing mutant PC-3-7 developed in Japan has enhanced cellulase production ability when @entity3 is used as the inducer. The comparative genomics analysis of PC-3-7 and its parent revealed a single-nucleotide mutation within the bgl2 gene encoding intracellular b-glucosidase II (BGLII/Cel1a), giving rise to an @entity2 substitution in PC-3-7, which could potentially account for the enhanced cellulase expression when these strains are cultivated on cellulose and @entity3 . RESULTS: To analyze the effects of the BGLII mutation in cellulase induction, we constructed both a bgl2 revertant and a disruptant. Enzymatic analysis of the transformant lysates showed that the strain expressing mutant BGLII exhibited weakened @entity3 hydrolytic activity, but produced some transglycosylation products, suggesting that the SNP in bgl2 strongly diminished cellobiase activity, but did not result in complete loss of function of BGLII. The analysis of the recombinant BGLII revealed that transglycosylation products might be oligosaccharides, composed probably of @entity0 linked b-1,4, b-1,3, or a mixture of both. PC-3-7 revertants of bgl2 exhibited reduced expression and inducibility of cellulase during growth on cellulose and @entity3 substrates. Furthermore, the effect of this bgl2 mutation was reproduced in the common strain QM9414 in which the transformants showed cellulase production comparable to that of PC-3-7. CONCLUSION: We conclude that BGLII plays an important role in cellulase induction in @entity4 and that the bgl2 mutation in PC-3-7 brought about enhanced cellulase expression on @entity3 . The results of the investigation using PC-3-7 suggested that other mutation(s) in PC-3-7 could also contribute to cellulase induction. Further investigation is essential to unravel the mechanism responsible for cellulase induction in @entity4 .

title: The impact of a single-nucleotide mutation of bgl2 on cellulase induction in a XXXX mutant.

answer: @entity4


abstract: INTRODUCTION: @entity2 is classified into two main types: secondary @entity2 accompanied by lymph node excision surgery or radiotherapy; and idiopathic @entity2 . Here we experienced a very rare case of @entity1 resulting from cardiac surgery that the @entity0 underwent 50 years previously. PRESENTATION OF CASE: A 62-year-old @entity0 experienced progressive unilateral lower leg @entity2 for recent years. After undergoing cardiac surgery at another hospital at the age of 12 years, she gradually developed left lower leg @entity1 . The cause of the @entity1 was unclear and it remained untreated. Her @entity1 gradually worsened in recent years, so she consulted the plastic surgery division of our hospital. DISCUSSSION: Perhaps the lymphatic structures of affected individuals differ prior to disease onset. If the mechanism of @entity1 outbreak is elucidated, @entity0 needing conservative and surgical therapy might be more easily identified. Knowing the outbreak mechanism of @entity1 would definitely ease the investigation of an unconventional case like this one. Conservative treatments for @entity2 , such as self-massage and compression therapy using garments, were immediately started. With these treatments, the leg volume and @entity1 reduced. CONCLUSION: The research on the cause of this case may be important step for elucidating the source of secondary @entity1 .

title: Unilateral lower limb XXXX resulting from a heart surgery performed 50 years prior.

answer: @entity2


abstract: UNASSIGNED: The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these newly expressed genes may acquire coding or non-coding functions and be preserved by natural selection. However, it is yet unclear which is the prevalence and underlying mechanisms of de novo gene emergence. In order to obtain a comprehensive view of this process, we have performed in-depth sequencing of the transcriptomes of four @entity0 species- @entity0 , @entity2 , macaque, and @entity1 -and subsequently compared the assembled transcripts and the corresponding syntenic genomic regions. This has resulted in the identification of over five thousand new multiexonic transcriptional events in @entity0 and/or @entity2 that are not observed in the rest of species. Using comparative genomics, we show that the expression of these transcripts is associated with the gain of regulatory motifs upstream of the @entity3 ( @entity3 ) and of @entity4 sites downstream of the @entity3 . In general, these transcripts show little evidence of purifying selection, suggesting that many of them are not functional. However, we find signatures of selection in a subset of de novo genes which have evidence of protein translation. Taken together, the data support a model in which frequently-occurring new transcriptional events in the genome provide the raw material for the evolution of new proteins.

title: Origins of De Novo Genes in @entity0 and XXXX .

answer: @entity2


abstract: UNASSIGNED: The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these newly expressed genes may acquire coding or non-coding functions and be preserved by natural selection. However, it is yet unclear which is the prevalence and underlying mechanisms of de novo gene emergence. In order to obtain a comprehensive view of this process, we have performed in-depth sequencing of the transcriptomes of four @entity0 species- @entity0 , @entity2 , macaque, and @entity1 -and subsequently compared the assembled transcripts and the corresponding syntenic genomic regions. This has resulted in the identification of over five thousand new multiexonic transcriptional events in @entity0 and/or @entity2 that are not observed in the rest of species. Using comparative genomics, we show that the expression of these transcripts is associated with the gain of regulatory motifs upstream of the @entity3 ( @entity3 ) and of @entity4 sites downstream of the @entity3 . In general, these transcripts show little evidence of purifying selection, suggesting that many of them are not functional. However, we find signatures of selection in a subset of de novo genes which have evidence of protein translation. Taken together, the data support a model in which frequently-occurring new transcriptional events in the genome provide the raw material for the evolution of new proteins.

title: Origins of De Novo Genes in XXXX and @entity2 .

answer: @entity0


abstract: IMPORTANCE: @entity5 ( @entity5 ) diagnosed in young @entity0 is rare, and the genomics and clinical characteristics of this disease are poorly understood. In contrast, the diagnosis of other @entity2 at a young age has been demonstrated to define unique disease biology. Herein, we report on the association of young age with targetable genomic alterations and prognosis in a cohort of 2237 @entity0 with @entity5 . OBJECTIVE: To determine the relationship between young age at diagnosis and the presence of a potentially targetable genomic alteration, disease prognosis, and natural history. DESIGN, SETTING, AND @entity0 : A cohort of all 2237 @entity0 with @entity5 who were genotyped at the Dana-Farber @entity2 Institute between January 2002 and December 2014 were identified. @entity2 genotype, @entity0 characteristics, and clinical outcomes were collected and studied at a National @entity2 Institute-designated comprehensive @entity2 center. Multivariate logistic regression was used to analyze the relationship between age and mutation status, and multivariate Cox proportional hazard models were fitted for survival analysis. MAIN OUTCOMES AND MEASURES: The frequency of targetable genomic alterations by defined age categories as well as the association of these age groups with survival. Age categories used in this analysis were younger than 40, 40 to 49, 50 to 59, 60 to 69, and 70 years or older. RESULTS: A cohort of 2237 @entity0 with @entity5 was studied. Of the 2237 @entity0 , 1939 (87%) had histologically confirmed @entity3 , 269 (12%) had @entity5 not otherwise specified, and 29 (1%) had squamous histologic findings; 1396 (63%) had either stage IIIB or IV @entity2 ; and median (range) age was 62 (20-95) years. We found that gene mutations for @entity4 (P   =   .02) and @entity7 (P   <   .001) were associated with @entity2 diagnosis at a younger age, and a similar trend existed for @entity6 (P   =   .15) and @entity9 (P   =   .10) but not BRAF @entity8 (P   =   .43). Among @entity0 tested for all 5 targetable genomic alterations (n   =   1325), younger age was associated with an increased frequency of a targetable genotype (P   <   .001). Those diagnosed at 50 years or younger have a 59% increased likelihood of harboring a targetable genotype. While presence of a potentially targetable genomic alteration treated with a targeted agent was associated with improved survival, the youngest and oldest age groups had similarly poor outcomes even when a targetable genotype was present. CONCLUSIONS AND RELEVANCE: Younger age is associated with an increased likelihood of harboring a targetable genotype and is an underappreciated clinical biomarker in @entity5 . The survival of young @entity0 with NCSLC is unexpectedly poor compared with other age groups, suggesting more aggressive disease biology. These findings underscore the importance of comprehensive genotyping, including next-generation sequencing, in younger @entity0 with @entity1 .

title: Association Between Younger Age and Targetable Genomic Alterations and Prognosis in XXXX .

answer: @entity5


abstract: Purpose: @entity1 ( @entity1 ), the most common cause of incurable @entity3 in the western world, is characterized by the dysfunction and eventual death of choroidal endothelial (CECs), RPE, and photoreceptor cells. Stem cell-based treatment strategies designed to replace photoreceptor and RPE cells currently are a major scientific focus. However, the success of these approaches likely also will require replacement of the underlying, supportive choroidal vasculature. The purpose of this study was to generate stem cell-derived CECs to develop efficient differentiation and transplantation protocols. Methods: Dermal fibroblasts from the @entity2 -GFP @entity0 were isolated and reprogrammed into two independent induced pluripotent stem cell (iPSC) lines via viral transduction of the transcription factors @entity6 , @entity11 , @entity4 , and c-Myc. @entity2 -GFP iPSCs were differentiated into CECs using a coculture method with either the RF6A CEC line or primary @entity0 CECs. Induced pluripotent stem cell-derived CECs were characterized via RT-PCR and immunocytochemistry for EC- and CEC-specific markers. Results: Induced pluripotent stem cells generated from @entity0 expressing green fluorescent protein (GFP) under control of the endothelial @entity2 promoter display classic pluripotency markers and stem cell morphology. Induced pluripotent stem cell-derived CECs express @entity14 , eNOS, @entity12 , @entity10 , @entity5 , @entity13 , @entity8 , @entity2 , @entity15 , @entity7 , and @entity9 . Conclusions: Induced pluripotent stem cell-derived CECs will be a valuable tool for modeling of choriocapillaris-specific insults in @entity1 and for use in future choroidal endothelial cell replacement approaches.

title: Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related XXXX .

answer: @entity1


abstract: Background: Survival after @entity3 ( @entity3 ) remains low, and tools for improved prediction of @entity0 at long-term risk for @entity3 are lacking. Alternative short-term approaches aimed at preemptive risk stratification and prevention are needed. Objective: To assess characteristics of symptoms in the 4 weeks before @entity3 and whether response to these symptoms is associated with better outcomes. Design: Ongoing prospective population-based study. Setting: Northwestern United States (2002 to 2012). @entity0 : Residents aged 35 to 65 years with @entity3 . Measurement: Assessment of symptoms in the 4 weeks preceding @entity3 and association with survival to hospital discharge. Results: Of 839 @entity0 with @entity3 and comprehensive assessment of symptoms (mean age, 52.6 years [SD, 8]; 75% @entity0 ), 430 (51%) had warning symptoms (50% of @entity0 vs. 53% of @entity0 ; P  = 0.59), mainly @entity2 and @entity4 . In most symptomatic @entity0 (93%), symptoms recurred within the 24 hours preceding @entity3 . Only 81 @entity0 (19%) called emergency medical services (911) to report symptoms before @entity3 ; these @entity0 were more likely to be @entity0 with a history of @entity1 (P  < 0.001) or continuous @entity2 (P  < 0.001). Survival when 911 was called in response to symptoms was 32.1% (95% CI, 21.8% to 42.4%) compared with 6.0% (CI, 3.5% to 8.5%) in those who did not call (P  < 0.001). Limitation: Potential for recall and response bias, symptom assessment not available in 24% of @entity0 , and missing data for some @entity0 and @entity3 characteristics. Conclusion: Warning symptoms frequently occur before @entity3 , but most are ignored. Emergent medical care was associated with survival in @entity0 with symptoms, so new approaches are needed for short-term prevention of @entity3 . Primary Funding Source: National Heart, Lung, and Blood Institute.

title: Warning Symptoms Are Associated With Survival From XXXX .

answer: @entity3


abstract: OBJECTIVE: Damage to intestinal epithelial tight junctions plays an important role in @entity3 . Recently we found that @entity4 Monoxide-Releasing Molecule-2 (CORM-2) is able to protect LPS-induced intestinal epithelial tight junction damage and in this study we will investigate if CORM-2 could protect intestinal epithelial tight junctions in the @entity2 cecal ligation and puncture (CLP) model. MATERIALS AND METHODS: The CLP model was generated using male Sprague-Dawley (SD) @entity2 according to standard procedure and treated with CORM-2 or inactive CORM-2 (iCORM-2), 8 mg/kg, i.v. immediately after CLP induction and euthanized after 24h or 72h (for mortality rate only). Morphological changes were investigated using both transmission electron and confocal microscopy. The levels of important TJ proteins and phosphorylation of myosin light chain (MLC) were examined using Western blotting. Cytokines, @entity7 and @entity6 were measured using ELISA kits. The overall intestinal epithelial permeability was evaluated using FD-4 as a marker. RESULTS: CORM-2, but not iCORM-2, significantly reduced @entity3 -induced @entity0 (including TJ disruption), TJ protein reduction (including zonula occludens-l (ZO-1), @entity8 and @entity5 ), MLC phosphorylation and proinflammatory cytokine release. The overall outcomes showed that CORM-2 suppressed @entity3 -induced intestinal epithelial permeability changes and reduced mortality rate of those septic @entity2 . CONCLUSIONS: Our data strongly suggest that CORM-2 could be a potential therapeutic reagent for @entity3 by suppressing @entity1 , restoring intestinal epithelial barrier and reducing mortality.

title: Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic XXXX .

answer: @entity2


abstract: INTRODUCTION: NF-kB ( @entity6 / @entity7 ) is a transcription factor involved in @entity3 -induced cell death resistance by promoting several antiapoptotic genes. We intend to relate the expression of NF-kB ( @entity6 and @entity7 ) with serum levels of @entity5 (PSA), both in normal males and in those with pathologic conditions of the prostate. MATERIALS AND METHODS: this study was carried out in 5 normal, 24 @entity4 ( @entity4 ) and 19 @entity0 with @entity2 ( @entity2 ). Immunohistochemical and Western blot analyses were performed on tissue and serum PSA was assayed by PSA DPC Immulite assays (Diagnostics Products Corporation, Los Angeles, CA). RESULTS: in controls, @entity7 NF-kB was not found and @entity6 was scantly detected in 60% normal samples in the cytoplasm of epithelial cells. Both @entity6 and @entity7 were expressed in 62.5% of the samples with @entity4 and in 63.2% of those with @entity2 . Both increased its frequency of expression with higher PSA serum levels. CONCLUSIONS: Activation of NF-kB revealed by its nuclear translocation in @entity2 could be related to @entity1 progression and elevated seric PSA levels. A better understanding of the biologic mechanism by which circulating PSA levels increase and its relation with NF-kB expression is needed. Possibly, NF-kB blockage could be used as a therapeutic target to counteract proliferation in @entity2 .

title: [ XXXX and NF-kB in prostatic disease: relation with @entity1 ].

answer: @entity5


abstract: INTRODUCTION: NF-kB ( @entity6 / @entity7 ) is a transcription factor involved in @entity3 -induced cell death resistance by promoting several antiapoptotic genes. We intend to relate the expression of NF-kB ( @entity6 and @entity7 ) with serum levels of @entity5 (PSA), both in normal males and in those with pathologic conditions of the prostate. MATERIALS AND METHODS: this study was carried out in 5 normal, 24 @entity4 ( @entity4 ) and 19 @entity0 with @entity2 ( @entity2 ). Immunohistochemical and Western blot analyses were performed on tissue and serum PSA was assayed by PSA DPC Immulite assays (Diagnostics Products Corporation, Los Angeles, CA). RESULTS: in controls, @entity7 NF-kB was not found and @entity6 was scantly detected in 60% normal samples in the cytoplasm of epithelial cells. Both @entity6 and @entity7 were expressed in 62.5% of the samples with @entity4 and in 63.2% of those with @entity2 . Both increased its frequency of expression with higher PSA serum levels. CONCLUSIONS: Activation of NF-kB revealed by its nuclear translocation in @entity2 could be related to @entity1 progression and elevated seric PSA levels. A better understanding of the biologic mechanism by which circulating PSA levels increase and its relation with NF-kB expression is needed. Possibly, NF-kB blockage could be used as a therapeutic target to counteract proliferation in @entity2 .

title: [ @entity5 and NF-kB in prostatic disease: relation with XXXX ].

answer: @entity1


abstract: OBJECTIVE: The aim of the present work is to evaluate the anxiolytic effect of a methanolic extract of Morus alba L. leaves in @entity0 . MATERIALS AND METHODS: The hole-board test, elevated plus-maze paradigm, open field test, and light/dark paradigm were used to assess the anxiolytic activity of the methanolic extract of @entity2 L. Morus alba extract (50, 100, and 200 mg/kg, i.p.) and @entity1 (1 mg/kg, i.p.) were administered 30 min before the tests. RESULTS: The results showed that the methanolic extract of @entity2 significantly increased the number and duration of head poking in the hole-board test. In the elevated plus-maze, the extract significantly increased the exploration of the open arm in similar way to that of @entity1 . At a dose of 200 mg/kg i.p. the extract significantly increased both the time spent in and the entries into the open arm by @entity0 . Further, in the open field test, the extract significantly increased rearing, assisted rearing, and number of squares traversed, all of which are demonstrations of exploratory behavior. In the light/dark paradigm, the extract produced significant increase in time spent in the lighted box as compared to vehicle. The spontaneous locomotor activity count, measured using an actophotometer, was significantly decreased in animals pretreated with @entity2 extract, indicating a remarkable sedative effect of the plant. CONCLUSION: The results of the present study suggest that a methanolic extract of @entity2 leaves may possess an anxiolytic effect.

title: Effect of Morus alba L. (mulberry) leaves on anxiety in XXXX .

answer: @entity0


abstract: BACKGROUND: The assessment of dental @entity1 among @entity0 will aid in dealing with management issues related to dental treatment. There is no study available from Pakistan on dental @entity1 in @entity0 . The aim of this study was to assess the prevalence of dental @entity1 in @entity0 attending a teaching dental hospital in Islamabad, Pakistan. METHODS: A cross-sectional study was conducted on 252 @entity0 aged between 5-10 years attending a dental clinic in a dental hospital in Islamabad, Pakistan. Dental @entity1 was assessed by using the Faces Version of the Modified @entity0 Dental @entity1 Scale. This scale uses faces as pictograms to indicate the levels of dental @entity1 making it easier for @entity0 to answer the questionnaire. RESULTS: A total of 252 @entity0 were observed for assessment of dental @entity1 having mean age of 7.88  1.55 years with 123 (48.8%) males and 129 (51.2%) females. Out of these @entity0 150 (59.5%) had previously visited a dentist and 102 (40.5%) had no experience with a dentist before; 38% (95/252) of @entity0 had moderate and severe dental @entity1 . Dental @entity1 decreased significantly with age (p=0.0003). The difference in @entity1 levels was not statistically significant between males and females and in different socio-economic status. CONCLUSION: This study has highlighted dental @entity1 as a potential public health concern regarding @entity0 in Pakistan. Assessment of dental @entity1 is a useful way to identify anxious dental @entity0 .

title: DENTAL ANXIETY AMONG XXXX OF AGE BETWEEN 5 TO 10 YEARS VISITING A TEACHING DENTAL HOSPITAL IN ISLAMABAD, PAKISTAN.

answer: @entity0


abstract: BACKGROUND: @entity1 is generally thought of as a " @entity0 's disease" because the prevalence of @entity1 and the rate of @entity2 are much higher in postmenopausal @entity0 than in older @entity0 . However, the absolute number of @entity0 affected by @entity1 and @entity2 is large, as at least 2.8 million @entity0 in the United States are thought to have @entity1 . QUESTIONS/PURPOSES: The purposes of this review are to (1) highlight gender differences in @entity1 and @entity2 risk, (2) describe disparities in treatment and outcomes after @entity2 between @entity0 and @entity0 , and (3) propose solutions to reducing disparities in treatment and prevention. METHODS: A literature survey was conducted using MEDLINE with a variety of search terms and using references from the author's personal collection of articles. A formal search strategy and exclusion criteria were not employed and the review is therefore selective. WHERE ARE WE NOW?: Postmenopausal @entity0 have a higher prevalence of @entity1 and greater incidence of @entity2 than older @entity0 . Despite the higher @entity2 risk in postmenopausal @entity0 , older @entity0 tend to have worse outcomes after @entity2 and poorer treatment rates, although less is known about the disease course in @entity0 . Multifaceted interventions to improve the screening and treatment for @entity1 were recently developed. WHERE DO WE NEED TO GO?: Improvement in treatment rates of those at risk, regardless of gender, is an important goal in @entity1 management. HOW DO WE GET THERE?: Further development and evaluation of cost-effective, multifaceted interventions for screening and treatment of @entity1 and @entity2 are needed; such interventions will likely improve the primary prevention of @entity2 .

title: Gender differences in XXXX and @entity2 .

answer: @entity1


abstract: BACKGROUND: @entity1 is generally thought of as a " @entity0 's disease" because the prevalence of @entity1 and the rate of @entity2 are much higher in postmenopausal @entity0 than in older @entity0 . However, the absolute number of @entity0 affected by @entity1 and @entity2 is large, as at least 2.8 million @entity0 in the United States are thought to have @entity1 . QUESTIONS/PURPOSES: The purposes of this review are to (1) highlight gender differences in @entity1 and @entity2 risk, (2) describe disparities in treatment and outcomes after @entity2 between @entity0 and @entity0 , and (3) propose solutions to reducing disparities in treatment and prevention. METHODS: A literature survey was conducted using MEDLINE with a variety of search terms and using references from the author's personal collection of articles. A formal search strategy and exclusion criteria were not employed and the review is therefore selective. WHERE ARE WE NOW?: Postmenopausal @entity0 have a higher prevalence of @entity1 and greater incidence of @entity2 than older @entity0 . Despite the higher @entity2 risk in postmenopausal @entity0 , older @entity0 tend to have worse outcomes after @entity2 and poorer treatment rates, although less is known about the disease course in @entity0 . Multifaceted interventions to improve the screening and treatment for @entity1 were recently developed. WHERE DO WE NEED TO GO?: Improvement in treatment rates of those at risk, regardless of gender, is an important goal in @entity1 management. HOW DO WE GET THERE?: Further development and evaluation of cost-effective, multifaceted interventions for screening and treatment of @entity1 and @entity2 are needed; such interventions will likely improve the primary prevention of @entity2 .

title: Gender differences in @entity1 and XXXX .

answer: @entity2


abstract: BACKGROUND: @entity6 ( @entity9 ) is an antitumor antibiotics used against @entity0 . But its @entity3 limits the therapy of @entity9 . OBJECTIVE: The purpose of this study was to evaluate @entity9 @entity3 and the alteration of energy metabolism after short term and long term treatment. METHODS: Male @entity2 were randomly assigned to four groups: Short term control group, short term @entity9 treatment group, long term control group and long term @entity9 treatment group. In short term treated group, @entity2 were injected with @entity9 i.p. at a dose of 2.5  mg/kg every 48  h for six equal injections. In long term, treated group, @entity2 were tail-intravenously injected with @entity9 at a dose of 3  mg/kg once a week for four weeks. At the end of the experiment, histopathological changes, general blood biomarkers, endogenous antioxidant enzymes, cardiac energy metabolism and related mRNA expression of AMPK signal pathway were determined. RESULTS: @entity9 induced prominent oxidative stress, a higher mortality rate, histological and ECG changes, obvious @entity8 , @entity4 and @entity4 in short term treatment @entity2 . In long term treatment @entity2 , @entity9 caused serious @entity1 and @entity4 , terrible @entity4 , clear alteration of substrate utilization and AMPK signal pathway. CONCLUSION: @entity9 treatment can induce different damages after short term and long term treatment. In short term treatment group, @entity2 experienced a terrible mortality rate about 40%, the @entity4 , @entity4 and an early @entity7 which are potential connected with reduction of @entity5 utilization. In the long term treatment group, serious @entity1 and obvious changes of mRNA expressions of AMPK signal pathway were observed. Meanwhile, the serious @entity4 and substrate utilization alteration denote an obviously @entity7 . This study could be helpful to develop therapy strategies of @entity9 complications for clinical application.

title: @entity6 XXXX changes myocardial energy metabolism in @entity2 .

answer: @entity3


abstract: BACKGROUND: @entity6 ( @entity9 ) is an antitumor antibiotics used against @entity0 . But its @entity3 limits the therapy of @entity9 . OBJECTIVE: The purpose of this study was to evaluate @entity9 @entity3 and the alteration of energy metabolism after short term and long term treatment. METHODS: Male @entity2 were randomly assigned to four groups: Short term control group, short term @entity9 treatment group, long term control group and long term @entity9 treatment group. In short term treated group, @entity2 were injected with @entity9 i.p. at a dose of 2.5  mg/kg every 48  h for six equal injections. In long term, treated group, @entity2 were tail-intravenously injected with @entity9 at a dose of 3  mg/kg once a week for four weeks. At the end of the experiment, histopathological changes, general blood biomarkers, endogenous antioxidant enzymes, cardiac energy metabolism and related mRNA expression of AMPK signal pathway were determined. RESULTS: @entity9 induced prominent oxidative stress, a higher mortality rate, histological and ECG changes, obvious @entity8 , @entity4 and @entity4 in short term treatment @entity2 . In long term treatment @entity2 , @entity9 caused serious @entity1 and @entity4 , terrible @entity4 , clear alteration of substrate utilization and AMPK signal pathway. CONCLUSION: @entity9 treatment can induce different damages after short term and long term treatment. In short term treatment group, @entity2 experienced a terrible mortality rate about 40%, the @entity4 , @entity4 and an early @entity7 which are potential connected with reduction of @entity5 utilization. In the long term treatment group, serious @entity1 and obvious changes of mRNA expressions of AMPK signal pathway were observed. Meanwhile, the serious @entity4 and substrate utilization alteration denote an obviously @entity7 . This study could be helpful to develop therapy strategies of @entity9 complications for clinical application.

title: XXXX @entity3 changes myocardial energy metabolism in @entity2 .

answer: @entity6


abstract: BACKGROUND: @entity6 ( @entity9 ) is an antitumor antibiotics used against @entity0 . But its @entity3 limits the therapy of @entity9 . OBJECTIVE: The purpose of this study was to evaluate @entity9 @entity3 and the alteration of energy metabolism after short term and long term treatment. METHODS: Male @entity2 were randomly assigned to four groups: Short term control group, short term @entity9 treatment group, long term control group and long term @entity9 treatment group. In short term treated group, @entity2 were injected with @entity9 i.p. at a dose of 2.5  mg/kg every 48  h for six equal injections. In long term, treated group, @entity2 were tail-intravenously injected with @entity9 at a dose of 3  mg/kg once a week for four weeks. At the end of the experiment, histopathological changes, general blood biomarkers, endogenous antioxidant enzymes, cardiac energy metabolism and related mRNA expression of AMPK signal pathway were determined. RESULTS: @entity9 induced prominent oxidative stress, a higher mortality rate, histological and ECG changes, obvious @entity8 , @entity4 and @entity4 in short term treatment @entity2 . In long term treatment @entity2 , @entity9 caused serious @entity1 and @entity4 , terrible @entity4 , clear alteration of substrate utilization and AMPK signal pathway. CONCLUSION: @entity9 treatment can induce different damages after short term and long term treatment. In short term treatment group, @entity2 experienced a terrible mortality rate about 40%, the @entity4 , @entity4 and an early @entity7 which are potential connected with reduction of @entity5 utilization. In the long term treatment group, serious @entity1 and obvious changes of mRNA expressions of AMPK signal pathway were observed. Meanwhile, the serious @entity4 and substrate utilization alteration denote an obviously @entity7 . This study could be helpful to develop therapy strategies of @entity9 complications for clinical application.

title: @entity6 @entity3 changes myocardial energy metabolism in XXXX .

answer: @entity2


abstract: PURPOSE: A keloid scar often appears at the incision site of @entity0 after median sternotomy. Use of @entity1 gel to treat @entity3 and fresh incisions has yielded encouraging results. In this study, we report our experience with the preventive use of @entity1 gel sheets for @entity2 after median sternotomy. METHODS: Nine @entity0 who underwent a median sternotomy were studied. A @entity1 gel sheet was kept directly on the surgical incision for 24 h starting 2 weeks after surgery. The treatment was repeated with a new sheet every 4 weeks for 24 weeks, at which times the subjective symptoms and the changes in @entity2 were determined. RESULTS: None of the @entity0 experienced an aggravation of any subjective symptoms during the 24-week study. After 24 weeks, all @entity0 were free of a keloid scar that showed a rise and contraction of skin and causes discomfort. No adverse events were reported by any of the @entity0 . CONCLUSION: A @entity1 gel sheet is safe and effective for the preventing the formation of @entity2 after median sternotomy.

title: Use of XXXX gel sheets for prevention of @entity2 after median sternotomy.

answer: @entity1


abstract: PURPOSE: A keloid scar often appears at the incision site of @entity0 after median sternotomy. Use of @entity1 gel to treat @entity3 and fresh incisions has yielded encouraging results. In this study, we report our experience with the preventive use of @entity1 gel sheets for @entity2 after median sternotomy. METHODS: Nine @entity0 who underwent a median sternotomy were studied. A @entity1 gel sheet was kept directly on the surgical incision for 24 h starting 2 weeks after surgery. The treatment was repeated with a new sheet every 4 weeks for 24 weeks, at which times the subjective symptoms and the changes in @entity2 were determined. RESULTS: None of the @entity0 experienced an aggravation of any subjective symptoms during the 24-week study. After 24 weeks, all @entity0 were free of a keloid scar that showed a rise and contraction of skin and causes discomfort. No adverse events were reported by any of the @entity0 . CONCLUSION: A @entity1 gel sheet is safe and effective for the preventing the formation of @entity2 after median sternotomy.

title: Use of @entity1 gel sheets for prevention of XXXX after median sternotomy.

answer: @entity2


abstract: In 1998, a amovie entitled "A Civil Action" was released. The movie described the Woburn case, begun in 1982 and concluded in 1990, one of the most famous cases of @entity6 pollution. In a small town near Boston, twelve @entity0 died of @entity4 , which seemed attributable to @entity6 contamination of the drinking water. The victims, however, could not win the case, since evidence that the identified chemicals could cause @entity4 and other @entity0 illnesses was rather sketchy. There have been many cases of @entity6 pollution in industrial nations including Japan, therefore, we reconsidered the missing link. Our conclusion is that the disease occurred not by a direct effect of the chemical hazard on biological macromolecules but by an indirect effect through the physiological system such as signal transduction and transcriptional regulation. In 1984, we reported a marked reduction in the regulatory @entity3 pool by @entity6 exposure, however, the biological significance was not well understood. Recently, we found that the DNA binding activity of @entity7 , a negative regulator of genes, is controlled by @entity3 , the regulation of which seems to explain how @entity4 develops. The heterodimer of @entity7 with @entity9 recognizes Maf recognition elements (MAREs) competing with the erythroid type positive regulator, a complex of @entity8 with @entity9 . @entity7 / @entity9 occupies MAREs under lower @entity3 conditions, whereas MAREs are open to @entity8 / @entity9 along with increasing @entity3 concentration. Since the @entity8 / @entity9 function is closely related to normal erythroid differentiation, of which disorders such as sideroblastic @entity2 are often related to @entity1 ; i.e., a @entity5 that can progress to @entity4 . Thus, a marked decline in regulatory @entity3 by @entity6 intoxication could be one of the pathways to @entity4 .

title: Regulatory XXXX and @entity6 intoxication: A possible explanation of the case of "A Civil Action".

answer: @entity3


abstract: In 1998, a amovie entitled "A Civil Action" was released. The movie described the Woburn case, begun in 1982 and concluded in 1990, one of the most famous cases of @entity6 pollution. In a small town near Boston, twelve @entity0 died of @entity4 , which seemed attributable to @entity6 contamination of the drinking water. The victims, however, could not win the case, since evidence that the identified chemicals could cause @entity4 and other @entity0 illnesses was rather sketchy. There have been many cases of @entity6 pollution in industrial nations including Japan, therefore, we reconsidered the missing link. Our conclusion is that the disease occurred not by a direct effect of the chemical hazard on biological macromolecules but by an indirect effect through the physiological system such as signal transduction and transcriptional regulation. In 1984, we reported a marked reduction in the regulatory @entity3 pool by @entity6 exposure, however, the biological significance was not well understood. Recently, we found that the DNA binding activity of @entity7 , a negative regulator of genes, is controlled by @entity3 , the regulation of which seems to explain how @entity4 develops. The heterodimer of @entity7 with @entity9 recognizes Maf recognition elements (MAREs) competing with the erythroid type positive regulator, a complex of @entity8 with @entity9 . @entity7 / @entity9 occupies MAREs under lower @entity3 conditions, whereas MAREs are open to @entity8 / @entity9 along with increasing @entity3 concentration. Since the @entity8 / @entity9 function is closely related to normal erythroid differentiation, of which disorders such as sideroblastic @entity2 are often related to @entity1 ; i.e., a @entity5 that can progress to @entity4 . Thus, a marked decline in regulatory @entity3 by @entity6 intoxication could be one of the pathways to @entity4 .

title: Regulatory @entity3 and XXXX intoxication: A possible explanation of the case of "A Civil Action".

answer: @entity6


abstract: To allow adoption of serum pepsinogen as a screening indicator of @entity1 , serum @entity2 _ II levels, the ratios of @entity2 / @entity3 and the serum @entity4 levels in a general population were studied using 850 samples selected at random from a rural area in Japan. The collected data were analyzed statistically to determine the distribution characteristics by various categories of sex and age. The following results were obtained:1. The distributions of @entity2 , the ratios of @entity2 / @entity3 and serum @entity4 values largely deviated from the normal distribution. Therefore, the use of non-parametrical methods was recommended for analysis of these data.2. Although no significant difference between all selected @entity0 and all selected @entity0 was observed in any of the three parameters of @entity2 and @entity3 levels and the ratios of @entity2 / @entity3 , a significant difference between @entity0 and @entity0 was observed for @entity2 levels in under-fifty age groups. On the other hand, the median serum @entity4 value (92.0 pg/ml) in all selected @entity0 was significantly lower than that (101.0 pg/ml) in all selected @entity0 . A statistically significant difference between @entity0 and @entity0 was observed in serum @entity4 levels both in the under-forty age group and in the sixty and over age group.3. No significant difference was observed in the pattern of changes in @entity2 levels with increasing age in either @entity0 or @entity0 . While @entity3 levels in @entity0 varied irregularly with advancing age, @entity3 levels in @entity0 showed obvious increases with advancing age. The ratios of @entity2 / @entity3 showed a tendency to decrease with advancing age in both @entity0 and women. Conversely, serum @entity4 levels increased with advancing age in both @entity0 and @entity0 .

title: Statistical analysis of serum @entity2 ( @entity2 ) and II ( @entity3 ) levels, @entity2 / @entity3 ratios and serum XXXX levels in a general population.

answer: @entity4


abstract: To allow adoption of serum pepsinogen as a screening indicator of @entity1 , serum @entity2 _ II levels, the ratios of @entity2 / @entity3 and the serum @entity4 levels in a general population were studied using 850 samples selected at random from a rural area in Japan. The collected data were analyzed statistically to determine the distribution characteristics by various categories of sex and age. The following results were obtained:1. The distributions of @entity2 , the ratios of @entity2 / @entity3 and serum @entity4 values largely deviated from the normal distribution. Therefore, the use of non-parametrical methods was recommended for analysis of these data.2. Although no significant difference between all selected @entity0 and all selected @entity0 was observed in any of the three parameters of @entity2 and @entity3 levels and the ratios of @entity2 / @entity3 , a significant difference between @entity0 and @entity0 was observed for @entity2 levels in under-fifty age groups. On the other hand, the median serum @entity4 value (92.0 pg/ml) in all selected @entity0 was significantly lower than that (101.0 pg/ml) in all selected @entity0 . A statistically significant difference between @entity0 and @entity0 was observed in serum @entity4 levels both in the under-forty age group and in the sixty and over age group.3. No significant difference was observed in the pattern of changes in @entity2 levels with increasing age in either @entity0 or @entity0 . While @entity3 levels in @entity0 varied irregularly with advancing age, @entity3 levels in @entity0 showed obvious increases with advancing age. The ratios of @entity2 / @entity3 showed a tendency to decrease with advancing age in both @entity0 and women. Conversely, serum @entity4 levels increased with advancing age in both @entity0 and @entity0 .

title: Statistical analysis of serum XXXX ( @entity2 ) and II ( @entity3 ) levels, @entity2 / @entity3 ratios and serum @entity4 levels in a general population.

answer: @entity2


abstract: To allow adoption of serum pepsinogen as a screening indicator of @entity1 , serum @entity2 _ II levels, the ratios of @entity2 / @entity3 and the serum @entity4 levels in a general population were studied using 850 samples selected at random from a rural area in Japan. The collected data were analyzed statistically to determine the distribution characteristics by various categories of sex and age. The following results were obtained:1. The distributions of @entity2 , the ratios of @entity2 / @entity3 and serum @entity4 values largely deviated from the normal distribution. Therefore, the use of non-parametrical methods was recommended for analysis of these data.2. Although no significant difference between all selected @entity0 and all selected @entity0 was observed in any of the three parameters of @entity2 and @entity3 levels and the ratios of @entity2 / @entity3 , a significant difference between @entity0 and @entity0 was observed for @entity2 levels in under-fifty age groups. On the other hand, the median serum @entity4 value (92.0 pg/ml) in all selected @entity0 was significantly lower than that (101.0 pg/ml) in all selected @entity0 . A statistically significant difference between @entity0 and @entity0 was observed in serum @entity4 levels both in the under-forty age group and in the sixty and over age group.3. No significant difference was observed in the pattern of changes in @entity2 levels with increasing age in either @entity0 or @entity0 . While @entity3 levels in @entity0 varied irregularly with advancing age, @entity3 levels in @entity0 showed obvious increases with advancing age. The ratios of @entity2 / @entity3 showed a tendency to decrease with advancing age in both @entity0 and women. Conversely, serum @entity4 levels increased with advancing age in both @entity0 and @entity0 .

title: Statistical analysis of serum @entity2 ( XXXX ) and II ( @entity3 ) levels, @entity2 / @entity3 ratios and serum @entity4 levels in a general population.

answer: @entity2


abstract: To allow adoption of serum pepsinogen as a screening indicator of @entity1 , serum @entity2 _ II levels, the ratios of @entity2 / @entity3 and the serum @entity4 levels in a general population were studied using 850 samples selected at random from a rural area in Japan. The collected data were analyzed statistically to determine the distribution characteristics by various categories of sex and age. The following results were obtained:1. The distributions of @entity2 , the ratios of @entity2 / @entity3 and serum @entity4 values largely deviated from the normal distribution. Therefore, the use of non-parametrical methods was recommended for analysis of these data.2. Although no significant difference between all selected @entity0 and all selected @entity0 was observed in any of the three parameters of @entity2 and @entity3 levels and the ratios of @entity2 / @entity3 , a significant difference between @entity0 and @entity0 was observed for @entity2 levels in under-fifty age groups. On the other hand, the median serum @entity4 value (92.0 pg/ml) in all selected @entity0 was significantly lower than that (101.0 pg/ml) in all selected @entity0 . A statistically significant difference between @entity0 and @entity0 was observed in serum @entity4 levels both in the under-forty age group and in the sixty and over age group.3. No significant difference was observed in the pattern of changes in @entity2 levels with increasing age in either @entity0 or @entity0 . While @entity3 levels in @entity0 varied irregularly with advancing age, @entity3 levels in @entity0 showed obvious increases with advancing age. The ratios of @entity2 / @entity3 showed a tendency to decrease with advancing age in both @entity0 and women. Conversely, serum @entity4 levels increased with advancing age in both @entity0 and @entity0 .

title: Statistical analysis of serum @entity2 ( @entity2 ) and II ( @entity3 ) levels, XXXX / @entity3 ratios and serum @entity4 levels in a general population.

answer: @entity2


abstract: To allow adoption of serum pepsinogen as a screening indicator of @entity1 , serum @entity2 _ II levels, the ratios of @entity2 / @entity3 and the serum @entity4 levels in a general population were studied using 850 samples selected at random from a rural area in Japan. The collected data were analyzed statistically to determine the distribution characteristics by various categories of sex and age. The following results were obtained:1. The distributions of @entity2 , the ratios of @entity2 / @entity3 and serum @entity4 values largely deviated from the normal distribution. Therefore, the use of non-parametrical methods was recommended for analysis of these data.2. Although no significant difference between all selected @entity0 and all selected @entity0 was observed in any of the three parameters of @entity2 and @entity3 levels and the ratios of @entity2 / @entity3 , a significant difference between @entity0 and @entity0 was observed for @entity2 levels in under-fifty age groups. On the other hand, the median serum @entity4 value (92.0 pg/ml) in all selected @entity0 was significantly lower than that (101.0 pg/ml) in all selected @entity0 . A statistically significant difference between @entity0 and @entity0 was observed in serum @entity4 levels both in the under-forty age group and in the sixty and over age group.3. No significant difference was observed in the pattern of changes in @entity2 levels with increasing age in either @entity0 or @entity0 . While @entity3 levels in @entity0 varied irregularly with advancing age, @entity3 levels in @entity0 showed obvious increases with advancing age. The ratios of @entity2 / @entity3 showed a tendency to decrease with advancing age in both @entity0 and women. Conversely, serum @entity4 levels increased with advancing age in both @entity0 and @entity0 .

title: Statistical analysis of serum @entity2 ( @entity2 ) and II ( XXXX ) levels, @entity2 / @entity3 ratios and serum @entity4 levels in a general population.

answer: @entity3


abstract: To allow adoption of serum pepsinogen as a screening indicator of @entity1 , serum @entity2 _ II levels, the ratios of @entity2 / @entity3 and the serum @entity4 levels in a general population were studied using 850 samples selected at random from a rural area in Japan. The collected data were analyzed statistically to determine the distribution characteristics by various categories of sex and age. The following results were obtained:1. The distributions of @entity2 , the ratios of @entity2 / @entity3 and serum @entity4 values largely deviated from the normal distribution. Therefore, the use of non-parametrical methods was recommended for analysis of these data.2. Although no significant difference between all selected @entity0 and all selected @entity0 was observed in any of the three parameters of @entity2 and @entity3 levels and the ratios of @entity2 / @entity3 , a significant difference between @entity0 and @entity0 was observed for @entity2 levels in under-fifty age groups. On the other hand, the median serum @entity4 value (92.0 pg/ml) in all selected @entity0 was significantly lower than that (101.0 pg/ml) in all selected @entity0 . A statistically significant difference between @entity0 and @entity0 was observed in serum @entity4 levels both in the under-forty age group and in the sixty and over age group.3. No significant difference was observed in the pattern of changes in @entity2 levels with increasing age in either @entity0 or @entity0 . While @entity3 levels in @entity0 varied irregularly with advancing age, @entity3 levels in @entity0 showed obvious increases with advancing age. The ratios of @entity2 / @entity3 showed a tendency to decrease with advancing age in both @entity0 and women. Conversely, serum @entity4 levels increased with advancing age in both @entity0 and @entity0 .

title: Statistical analysis of serum @entity2 ( @entity2 ) and II ( @entity3 ) levels, @entity2 / XXXX ratios and serum @entity4 levels in a general population.

answer: @entity3


abstract: @entity2 and A. rhizogenes transport single-stranded DNA (ssDNA; T-strands) and virulence proteins into plant cells through a type IV secretion system. DNA transfer initiates when @entity4 nicks border sequences in the @entity0 -inducing plasmid, attaches to the 5' end, and pilots T-strands into plant cells. @entity2 translocates ssDNA-binding protein @entity3 into plant cells where it targets T-strands into the nucleus. Some A. rhizogenes strains lack @entity3 but transfer T-strands efficiently due to the GALLS gene, which complements an A. tumefaciens @entity3 mutant. @entity3 and full-length GALLS (GALLS-FL) contain nuclear localization sequences that target these proteins to the plant cell nucleus. @entity3 binds cooperatively to T-strands allowing it to move ssDNA without @entity1 hydrolysis. Unlike @entity3 , GALLS-FL contains @entity1 -binding and helicase motifs similar to those in TraA, a strand transferase involved in conjugation. @entity3 may accumulate in the nucleus and pull T-strands into the nucleus using the force generated by cooperative DNA binding. GALLS-FL accumulates inside the nucleus where its predicted @entity1 -dependent strand transferase may pull T-strands into the nucleus. These different mechanisms for nuclear import of T-strands may affect the efficiency and quality of transgenic events in plant biotechnology applications.

title: XXXX and A. rhizogenes use different proteins to transport bacterial DNA into the plant cell nucleus.

answer: @entity2


abstract: Regular consumption of fruits and vegetables is associated with reduced risks of certain @entity1 and other diseases in observational studies and animal models of @entity0 diseases. The aim of the present study was to investigate whether feeding of @entity2 with whole raw apple has potentially chemopreventive properties by affecting markers of @entity4 . The end-point was preneoplastic changes in the colon known as @entity6 ( @entity6 ). @entity2 initiated with the colon carcinogen @entity7 ( @entity5 ) were given 0, 5, or 10 g apple/day for 13 wk. The group fed 5 g apple but not 10 g had a significantly lower number of @entity6 (P = 0.009) compared to the initiated control. DNA damage evaluated by the comet assay was significantly increased in leucocytes of DMH-treated animals (P = 0.021). No antigenotoxic effect of apple feeding was apparent in the colon. Apple feeding tended to lower DNA damage in the liver (P = 0.136 in DMH-initiated and P = 0.284 in noninitiated @entity2 ). Liver @entity3 aminotransferase was significantly increased in @entity2 fed apples (P = 0.008 in DMH-initiated and P = 0.019 in noninitiated @entity2 ). In conclusion, feeding whole fresh apple may affect the occurrence of preneoplastic changes in the @entity2 colon, but the effect was not gradual.

title: The effect of apple feeding on markers of XXXX .

answer: @entity4


abstract: Primary @entity3 of the heart is very rare, accounting for 5% of @entity2 . Of the few cases reported in the literature to date, nearly all have had a very poor outcome. We present a further case. This uncommon @entity1 has no specific symptoms during its development, which results in delayed diagnosis. Echocardiography, chest computed tomography, and magnetic resonance imaging can provide effective information about this @entity1 . With the identification of the characteristic and diagnostic @entity4 t(X; 18), this @entity1 will become increasingly recognized. @entity3 of the heart requires surgical intervention to improve the prognosis. Adjuvant and/or genetic therapy pre- or postoperation can help prolong life. Chemotherapy is usually recommended as it may benefit the @entity0 . The key to treatment in the future is to find new therapeutic agents. Further elucidation of the effects of this @entity4 may lead to better-directed therapies in future.

title: Primary XXXX of the heart.

answer: @entity3


abstract: In @entity0 @entity2 in the mesial and anterior regions of the thalami are frequently associated with @entity4 . In this review paper, we scrutinized 41 papers published between 1983 and 2009 that provided data on a total of 83 @entity0 with the critical @entity5 (i.e. 17 @entity0 with right-sided lesions, 25 with left-sided lesions and 41 with bilateral lesions). We aimed to find answers to the following questions concerning the vascular @entity6 : (i) Which qualitative pattern of @entity3 (and associated cognitive and @entity1 ) do these @entity0 present? (ii) Which lesioned intrathalamic structures are primarily responsible for the @entity4 ? (iii) Are the recollection and familiarity components of declarative memory underlain by the same or by different thalamic structures? Results of the review indicate that, similar to @entity0 with @entity4 due to mesio-temporal lobe damage, @entity0 with vascular thalamic @entity4 display a prevalent deficit of declarative anterograde long-term memory, a less consistent deficit of declarative retrograde long-term memory and substantially spared short-term and implicit memory. Unlike mesio-temporal lobe @entity0 , however, vascular thalamic amnesics often present @entity1 similar to those observed in @entity0 with frontal damage. The presence of an @entity4 in @entity0 with thalamic @entity2 is strongly predicted by involvement of the mammillo-thalamic tract, which connects the anterior nuclei complex to the hippocampus proper via the fornix and the mammillary bodies. Finally, data reported in a few single cases provide support for the hypothesis that thalamic regions connected to distinct areas of the mesio-temporal lobe play differential roles in recollection and familiarity processes. The mammillo-thalamic tract/anterior nuclei axis seems primarily implicated in recollective processes, whereas the ventroamygdalofugal pathway/medio-dorsal axis primarily underlies familiarity processes.

title: Vascular thalamic XXXX : a reappraisal.

answer: @entity4


abstract: OBJECTIVES/HYPOTHESIS: Since the concept of @entity2 dopaminergic pathway emerged, studies have been proposed to investigate if dopaminergic agents influence @entity2 . We hypothesized that @entity3 , an agonist on D2/D3 receptors, may antagonize @entity2 in the @entity5 @entity0 (in the frequency range of 250 to 8,000 Hz) in a dose schedule accepted for the treatment of @entity1 in elderly @entity0 . STUDY DESIGN: We designed a randomized, prospective, placebo-controlled and double-blind trial. METHODS: Forty @entity5 @entity0 aged 50 years or older with subjective @entity2 were randomized to two groups (20 @entity0 in both). @entity0 in the drug group took @entity3 over a period of 4 weeks according to a treatment schedule as follows: week 1, 0.088 mg t.i.d.; week 2, 0.18 mg t.i.d.; week 3, 0.7 mg t.i.d.; week 4, 0.18 mg t.i.d. over 3 days and 0.088 mg t.i.d. the rest of the week. @entity0 in the second group received placebo. Determination of subjective grading of @entity2 , the @entity4 inventory (THI) questionnaire and electrocochleography (ECOG) examinations served as the end points. Subjective audiometry was used to produce secondary data. A significant improvement in @entity2 annoyance is found in the group treated with @entity3 versus placebo with respect to @entity2 and a @entity2 greater than 30 dB. However, neither ECOG nor subjective pure-tone threshold audiometry revealed any change in hearing threshold in response to either @entity3 or placebo. CONCLUSIONS: @entity3 is an effective agent against subjective @entity2 associated with @entity5 at a dose schedule used for the treatment of @entity1 . The drug did not change hearing threshold.

title: Tinnitus control by dopamine agonist XXXX in @entity5 @entity0 : a randomized, placebo-controlled, double-blind study.

answer: @entity3


abstract: OBJECTIVES/HYPOTHESIS: Since the concept of @entity2 dopaminergic pathway emerged, studies have been proposed to investigate if dopaminergic agents influence @entity2 . We hypothesized that @entity3 , an agonist on D2/D3 receptors, may antagonize @entity2 in the @entity5 @entity0 (in the frequency range of 250 to 8,000 Hz) in a dose schedule accepted for the treatment of @entity1 in elderly @entity0 . STUDY DESIGN: We designed a randomized, prospective, placebo-controlled and double-blind trial. METHODS: Forty @entity5 @entity0 aged 50 years or older with subjective @entity2 were randomized to two groups (20 @entity0 in both). @entity0 in the drug group took @entity3 over a period of 4 weeks according to a treatment schedule as follows: week 1, 0.088 mg t.i.d.; week 2, 0.18 mg t.i.d.; week 3, 0.7 mg t.i.d.; week 4, 0.18 mg t.i.d. over 3 days and 0.088 mg t.i.d. the rest of the week. @entity0 in the second group received placebo. Determination of subjective grading of @entity2 , the @entity4 inventory (THI) questionnaire and electrocochleography (ECOG) examinations served as the end points. Subjective audiometry was used to produce secondary data. A significant improvement in @entity2 annoyance is found in the group treated with @entity3 versus placebo with respect to @entity2 and a @entity2 greater than 30 dB. However, neither ECOG nor subjective pure-tone threshold audiometry revealed any change in hearing threshold in response to either @entity3 or placebo. CONCLUSIONS: @entity3 is an effective agent against subjective @entity2 associated with @entity5 at a dose schedule used for the treatment of @entity1 . The drug did not change hearing threshold.

title: Tinnitus control by dopamine agonist @entity3 in XXXX @entity0 : a randomized, placebo-controlled, double-blind study.

answer: @entity5


abstract: OBJECTIVES/HYPOTHESIS: Since the concept of @entity2 dopaminergic pathway emerged, studies have been proposed to investigate if dopaminergic agents influence @entity2 . We hypothesized that @entity3 , an agonist on D2/D3 receptors, may antagonize @entity2 in the @entity5 @entity0 (in the frequency range of 250 to 8,000 Hz) in a dose schedule accepted for the treatment of @entity1 in elderly @entity0 . STUDY DESIGN: We designed a randomized, prospective, placebo-controlled and double-blind trial. METHODS: Forty @entity5 @entity0 aged 50 years or older with subjective @entity2 were randomized to two groups (20 @entity0 in both). @entity0 in the drug group took @entity3 over a period of 4 weeks according to a treatment schedule as follows: week 1, 0.088 mg t.i.d.; week 2, 0.18 mg t.i.d.; week 3, 0.7 mg t.i.d.; week 4, 0.18 mg t.i.d. over 3 days and 0.088 mg t.i.d. the rest of the week. @entity0 in the second group received placebo. Determination of subjective grading of @entity2 , the @entity4 inventory (THI) questionnaire and electrocochleography (ECOG) examinations served as the end points. Subjective audiometry was used to produce secondary data. A significant improvement in @entity2 annoyance is found in the group treated with @entity3 versus placebo with respect to @entity2 and a @entity2 greater than 30 dB. However, neither ECOG nor subjective pure-tone threshold audiometry revealed any change in hearing threshold in response to either @entity3 or placebo. CONCLUSIONS: @entity3 is an effective agent against subjective @entity2 associated with @entity5 at a dose schedule used for the treatment of @entity1 . The drug did not change hearing threshold.

title: Tinnitus control by dopamine agonist @entity3 in @entity5 XXXX : a randomized, placebo-controlled, double-blind study.

answer: @entity0


abstract: OBJECTIVE: Extracranial @entity4 are uncommon @entity1 . Even with conservative management complications can arise, such as delayed cerebral @entity3 due to flow-limitation. Though endovascular therapy can be curative, literature demonstrating a preferred technique is scant. Our goal was to evaluate the use of one technique only - the deployment of overlapping self-expandable porous stents - to treat a series of extracranial @entity4 . METHODS: From 2008 to 2014, 14 consecutive cases of symptomatic extracranial @entity4 were managed with single or multi-layer porous stents at our institution. Each @entity0 underwent a standardized angiographic follow-up at 6 months. Twelve @entity0 also received a follow-up CT angiogram at 12 months, and yearly thereafter (median radiographic follow-up = 38 months). The total clinical follow-up period ranged between 6 and 69 months (median = 46 months). RESULTS: In our series, each of the extracranial @entity4 appeared to be the result of carotid artery dissection with associated @entity2 at the origin of every @entity5 . Endovascular treatment consisted of one to three layers of self-expandable porous stents placed without balloon angioplasty. Immediate post-stenting angiographic images were notable for stagnant opacification of the @entity5 through the stent(s). All @entity5 were completely obliterated by the 6-month follow-up angiogram and remained so throughout the radiographic follow-up period. Complications were minimal, consisting of one @entity0 developing a mild post-treatment @entity6 that resolved during clinical follow-up. CONCLUSION: Extracranial @entity4 can be successfully obliterated with the use of porous, self-expandable stents alone.

title: Efficacy of a Self-Expandable Porous Stent as the Sole Curative Treatment for Extracranial Carotid XXXX .

answer: @entity5


abstract: In spite of recent advances in knowledge concerning the detailed biochemistry of @entity3 , the diagnosis of @entity1 remains an important problem of clinical judgement in many instances. Laboratory support relies initially on a series of screening tests designed to investigate the general nature of @entity8 . Recent interest in these aspects is centred on standardization and quality assurance of methods and results. Procedures have been recommended in an attempt to unify data. Several aspects of conventional laboratory investigations have been modified and the reliability of diagnostic information has been improved. Some relatively recent findings have extended the application to coagulation studies. For example, the discovery of protein C, a potent physiological inhibitor of @entity3 , has clarified the nature of the @entity8 in some @entity0 with @entity2 . In addition, close analysis of plasma from @entity0 with @entity6 has stimulated interest in the association between the haemostatic, neurological and @entity5 recorded in these @entity0 . More recently, sophisticated techniques for the diagnosis of @entity7 factor defects have been developed. Carrier detection of the @entity4 is undertaken widely with reasonable success and reliable prenatal diagnosis procedures have been established in specialized centres. Unequivocal information regarding the diagnosis of carrier status in some families is obtained by the use of gene analysis and linked polymorphisms. Precise details of the genes for several clotting factors have been recorded. Future development in this field is likely to improve the clinical course of many @entity7 .

title: Laboratory support in the diagnosis of XXXX .

answer: @entity7


abstract: The face is a common localization for @entity3 . Mohs surgery or delayed Mohs surgery are considered the gold standard of treatment despite new drug developments. We analyzed our @entity0 files over a three-year period. Only large @entity2 >= 3 cm in diameter after complete @entity1 removal were considered. Twenty @entity0 (9 @entity0 and 11 @entity0 ) were found, with a mean age of 83.6 years. The following @entity1 entities were responsible for large defects: basal and @entity5 , @entity4 , @entity7 , @entity6 , and @entity8 . Surgery was performed in all cases using regional or local anesthesia. Defect repair was done using linear sutures (n=1), skin grafts (n=1), and flaps (n=18). The various types of repair are illustrated in this review, advantages and limitations of each type of repair are discussed. @entity0 satisfaction was high. Complications or adverse events were rare. The need for repair of large @entity2 after @entity1 surgery is not uncommon. Careful planning and the use of a number of techniques allows a tailored approach for each @entity0 .

title: Reconstruction of Large XXXX after Delayed Mohs Surgery for Skin Cancer.

answer: @entity2


abstract: BACKGROUND: Postpartum @entity4 (PPH) rates continue to rise in the developed world. A recent study found that any skin-to-skin contact and breastfeeding within 30min of birth was associated with an almost 50% reduction in PPH rates. Improved @entity3 release is the biological reason proposed to explain this. The combination of skin-to-skin contact and breastfeeding within 30min of birth is termed 'Pronurturance'. Midwifery theory and research claims that optimal third stage care is more holistic than simple Pronurturnace which suggests that further reductions in PPH rates may be possible. QUESTION: What can midwives and @entity0 do to minimise @entity2 in the third and fourth stages of labour? METHOD: We present a new theory that describes and explains how to optimise the @entity0 's reproductive psychophysiology in the third and fourth stages of labour to ensure a well contracted uterus which inhibits excessive @entity4 regardless of risk status or whether active management was used. In developing the Pronurturance Plus theory we expand upon what is already known about @entity3 in relation to simple pronurturance to integrate concepts from birth territory theory, @entity1 , mindfulness psychology and the autonomic nervous system to develop an holistic understanding of how to optimise care and minimise PPH. CONCLUSION: Pronurturance Plus is a psycho-biologically grounded theory which is consistent with existing evidence. It is free, natural and socially desirable.

title: Pronurturance Plus at birth: A risk reduction strategy for preventing postpartum XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity0 adipose-derived stem cells (hASCs) become an appealing source for regenerative medicine. However, with the multi-passage or cryopreservation for large-scale growth procedures in terms of preclinical and clinical purposes, hASCs often reveal defective cell viability, which is a major obstacle for cell therapy. In our study, the effects of induced pluripotent stem cells-derived conditioned medium (iPS-CM) on the proliferation and anti-apoptosis in hASCs were investigated. hASCs at passage 1 were identified by the analysis of typical surface antigens with flow cytometry assay and adipogenic and osteogenic differentiation. The effect of iPS-CM on the proliferation in hASCs was analyzed by cell cycle assay and Ki67/P27 quantitative polymerase chain reaction analysis. The effect of iPS-CM on the anti-apoptosis of hASCs irradiated by 468  J/m(2) of ultraviolet C was investigated by @entity4 / @entity3 analysis, mitochondrial membrane potential assay, intracellular reactive @entity1 species assay, Western blotting and caspase activity assays. The effect of iPS-CM on the surface antigen expressions of hASCs was analyzed using flow cytometry assay. The levels of Activin A and @entity2 in culture supernatant of hASCs with different treatments were also detected by enzyme-linked immunosorbent assay. iPS-CM promoted proliferation and inhibited apoptosis of hASCs. This discovery demonstrates that iPS-CM might be used as one of the available means to overcome the propagation obstacle for hASCs and make for large-scale growth procedures in terms of preclinical and clinical purposes.

title: Effects of induced pluripotent stem cells-derived conditioned medium on the proliferation and anti-apoptosis of XXXX adipose-derived stem cells.

answer: @entity0


abstract: UNASSIGNED: We examined whether @entity1 is impaired with a low @entity5 diet formulated to elicit @entity4 (LCKD) versus a mixed-macronutrient @entity9 ( @entity9 ). Male @entity0 (9-10 weeks of age, 300-325 g) were provided isoenergetic amounts of a LCKD or a @entity9 for 6 weeks. In @entity10 , basal serum and gastrocnemius assessments were performed. In @entity8 , @entity0 were resistance-exercised for one bout and were euthanized 90-270 min following exercise for gastrocnemius analyses. In AIM 3, @entity0 voluntarily-exercised daily using resistance-loaded running wheels, and hind limb muscles were analyzed for @entity3 markers at the end of the 6 week protocol. In @entity10 , basal levels of gastrocnemius phosphorylated (p)-rps6, p-4EBP1 and p-AMPKa were similar between diets, although serum insulin (P<0.01), serum @entity2 (P<0.001), and several essential @entity6 levels (P<0.05) were lower in LCKD-fed @entity0 . In @entity8 , LCKD- and @entity9 -fed @entity0 exhibited increased post-exercise muscle protein synthesis (MPS) levels (P<0.0125), but no diet effect was observed (P=0.59). In AIM 3, chronically exercise-trained LCKD- and @entity9 -fed @entity0 presented similar increases in relative hind limb muscle masses compared to their sedentary counterparts (12-24%, p<0.05), but there was no between-diet effects. Importantly, the LCKD induced 'mild' nutritional @entity4 , as the LCKD-fed @entity0 in @entity8 exhibited ~1.5-fold greater serum @entity7 levels relative to @entity9 -fed @entity0 (diet effect P=0.003). This study demonstrates that the tested LCKD in rodents, while only eliciting mild nutritional @entity4 , does not impair the acute or chronic skeletal muscle @entity3 responses to resistance exercise.

title: A putative ketogenic diet elicits mild nutritional XXXX but does not impair the acute or chronic @entity3 responses to resistance exercise in rodents.

answer: @entity4


abstract: UNASSIGNED: We examined whether @entity1 is impaired with a low @entity5 diet formulated to elicit @entity4 (LCKD) versus a mixed-macronutrient @entity9 ( @entity9 ). Male @entity0 (9-10 weeks of age, 300-325 g) were provided isoenergetic amounts of a LCKD or a @entity9 for 6 weeks. In @entity10 , basal serum and gastrocnemius assessments were performed. In @entity8 , @entity0 were resistance-exercised for one bout and were euthanized 90-270 min following exercise for gastrocnemius analyses. In AIM 3, @entity0 voluntarily-exercised daily using resistance-loaded running wheels, and hind limb muscles were analyzed for @entity3 markers at the end of the 6 week protocol. In @entity10 , basal levels of gastrocnemius phosphorylated (p)-rps6, p-4EBP1 and p-AMPKa were similar between diets, although serum insulin (P<0.01), serum @entity2 (P<0.001), and several essential @entity6 levels (P<0.05) were lower in LCKD-fed @entity0 . In @entity8 , LCKD- and @entity9 -fed @entity0 exhibited increased post-exercise muscle protein synthesis (MPS) levels (P<0.0125), but no diet effect was observed (P=0.59). In AIM 3, chronically exercise-trained LCKD- and @entity9 -fed @entity0 presented similar increases in relative hind limb muscle masses compared to their sedentary counterparts (12-24%, p<0.05), but there was no between-diet effects. Importantly, the LCKD induced 'mild' nutritional @entity4 , as the LCKD-fed @entity0 in @entity8 exhibited ~1.5-fold greater serum @entity7 levels relative to @entity9 -fed @entity0 (diet effect P=0.003). This study demonstrates that the tested LCKD in rodents, while only eliciting mild nutritional @entity4 , does not impair the acute or chronic skeletal muscle @entity3 responses to resistance exercise.

title: A putative ketogenic diet elicits mild nutritional @entity4 but does not impair the acute or chronic XXXX responses to resistance exercise in rodents.

answer: @entity3


abstract: OBJECTIVES: To assess the efficacy and the safety of our rapid detoxificationprotocol in preventing signs and symptoms of withdrawal and @entity1 severity. DESIGN: Prospective, open-label case series study. SETTINGS: Public primary care at the @entity1 and Palliative Care Unit of the Infermi Hospital of Rimini, Italy. @entity0 : The authors studied 10 consecutive @entity0 suffering from chronic noncancer @entity1 who were refractory to intrathecal (IT) @entity2 , and hence indicated for @entity8 therapy. INTERVENTIONS: IT pump was refilled with saline solution, and each @entity0 received endovenous @entity2 , oral @entity3 , @entity7 , and @entity5 for the first 3 days, and slow-release @entity4 , oral @entity3 , and @entity7 for 10 days. @entity8 therapy was started at the end of the 2-week detoxification treatment. MAIN OUTCOME MEASURES: The observer-rated opioid withdrawal scale (OOWS) was used for the assessment of @entity6 , visual analogue scale was used for @entity1 intensity assessment, and also adverse events were recorded. RESULTS: @entity6 were experienced by 3 @entity0 (30 percent). Their average OOWS decreased significantly (p < 0.05) from 4.3 +/- 2.5 to 1.7 +/- 0.6 at days 3 and 14 of protocol, respectively, with no increment of @entity1 intensity. @entity6 were resolved in 4 days on average without the need of adjuvant medications. One @entity0 with high @entity2 dosage (20 mg/d), interestingly, did not show any @entity6 . CONCLUSIONS: The detoxification protocol was effective in preventing @entity6 without increasing @entity1 severity, allowing to rapidly convert IT @entity2 to @entity8 monotherapy in @entity0 who are refractory to @entity2 .

title: @entity8 : A rapid detoxification protocol for the conversion from intrathecal XXXX --the Raffaeli Detoxification Model.

answer: @entity2


abstract: OBJECTIVES: To assess the efficacy and the safety of our rapid detoxificationprotocol in preventing signs and symptoms of withdrawal and @entity1 severity. DESIGN: Prospective, open-label case series study. SETTINGS: Public primary care at the @entity1 and Palliative Care Unit of the Infermi Hospital of Rimini, Italy. @entity0 : The authors studied 10 consecutive @entity0 suffering from chronic noncancer @entity1 who were refractory to intrathecal (IT) @entity2 , and hence indicated for @entity8 therapy. INTERVENTIONS: IT pump was refilled with saline solution, and each @entity0 received endovenous @entity2 , oral @entity3 , @entity7 , and @entity5 for the first 3 days, and slow-release @entity4 , oral @entity3 , and @entity7 for 10 days. @entity8 therapy was started at the end of the 2-week detoxification treatment. MAIN OUTCOME MEASURES: The observer-rated opioid withdrawal scale (OOWS) was used for the assessment of @entity6 , visual analogue scale was used for @entity1 intensity assessment, and also adverse events were recorded. RESULTS: @entity6 were experienced by 3 @entity0 (30 percent). Their average OOWS decreased significantly (p < 0.05) from 4.3 +/- 2.5 to 1.7 +/- 0.6 at days 3 and 14 of protocol, respectively, with no increment of @entity1 intensity. @entity6 were resolved in 4 days on average without the need of adjuvant medications. One @entity0 with high @entity2 dosage (20 mg/d), interestingly, did not show any @entity6 . CONCLUSIONS: The detoxification protocol was effective in preventing @entity6 without increasing @entity1 severity, allowing to rapidly convert IT @entity2 to @entity8 monotherapy in @entity0 who are refractory to @entity2 .

title: XXXX : A rapid detoxification protocol for the conversion from intrathecal @entity2 --the Raffaeli Detoxification Model.

answer: @entity8


abstract: BACKGROUND: @entity3 ( @entity3 ) and Roux limb compression (RC) are recognized complications after retrocolic laparoscopic Roux-en-Y gastric bypass for @entity1 . The aim of the present study was to systematically identify the surgical technical errors leading to these complications. METHODS: An observational clinical @entity0 reliability assessment approach was used to analyze the operating videos of 3 groups: an @entity3 group (n = 12), a Roux compression group (n = 13), and a control group (no complications, n = 21). Two investigators, unaware of the outcomes, reviewed all videos, using special rating software. All errors were categorized using the external error mode system and further described if a direct consequential error (e.g., @entity4 ) was found. RESULTS: An analysis of data showed that, on average, more errors occurred in the complication groups than in the control group ( @entity3 5.85, Roux compression 3.54, control .90, P < .001). The strongest differences were found for missing intermesenteric stitches on both sides of the Roux limb. Logistic regression analysis showed that a missed stitch between the mesentery of the Roux limb and the transverse mesocolon was an independent predictor for @entity3 (B = 1.727, P = .025). No technical or consequential errors could be identified as responsible for RC. CONCLUSION: The observational clinical @entity0 reliability analysis is a useful method to identify operative failure. For retrocolic, retrogastric laparoscopic Roux-en-Y gastric bypass, a systematic approach for the closure of the transverse mesenteric window might prevent @entity2 .

title: Root cause analysis of internal hernia and Roux limb compression after laparoscopic Roux-en-Y gastric bypass using observational clinical XXXX reliability assessment.

answer: @entity0


abstract: A prospective randomised trial was performed on 100 @entity0 undergoing coronary artery bypass grafting without concomitant procedure. The study group commenced oral @entity5 40 mg three times daily on the first post-operative day while the control group received no antiarrhythmic agents. The pre-operative characteristics of both groups were similar with the exception of the incidence of @entity1 which was greater in the @entity5 group (P = 0.04). Myocardial protection was achieved with @entity7 . Cardiopulmonary bypass times, aortic cross clamp times and graft numbers were similar for both groups. Nine @entity0 were excluded on the first post-operative day; the remainder were studied for 8 days. @entity6 ( @entity3 , @entity4 or paroxysmal @entity6 ) were detected in 8 @entity0 in the study group (n = 44) and in 5 @entity0 in the control group (n = 47). The difference was not significant (P = 0.3). The ventricular rate in @entity0 taking @entity5 who developed @entity6 was 138 +/- 14.9 compared with 156.8 +/- 17.9 in the control group, but the difference failed to reach significant levels (P = 0.065). In conclusion, prophylactic oral @entity5 40 mg given three times daily after coronary artery surgery failed to decrease the incidence of post-operative @entity6 or to significantly influence the ventricular rate if @entity2 developed.

title: Oral XXXX fails to prevent @entity6 following coronary artery surgery.

answer: @entity5


abstract: A prospective randomised trial was performed on 100 @entity0 undergoing coronary artery bypass grafting without concomitant procedure. The study group commenced oral @entity5 40 mg three times daily on the first post-operative day while the control group received no antiarrhythmic agents. The pre-operative characteristics of both groups were similar with the exception of the incidence of @entity1 which was greater in the @entity5 group (P = 0.04). Myocardial protection was achieved with @entity7 . Cardiopulmonary bypass times, aortic cross clamp times and graft numbers were similar for both groups. Nine @entity0 were excluded on the first post-operative day; the remainder were studied for 8 days. @entity6 ( @entity3 , @entity4 or paroxysmal @entity6 ) were detected in 8 @entity0 in the study group (n = 44) and in 5 @entity0 in the control group (n = 47). The difference was not significant (P = 0.3). The ventricular rate in @entity0 taking @entity5 who developed @entity6 was 138 +/- 14.9 compared with 156.8 +/- 17.9 in the control group, but the difference failed to reach significant levels (P = 0.065). In conclusion, prophylactic oral @entity5 40 mg given three times daily after coronary artery surgery failed to decrease the incidence of post-operative @entity6 or to significantly influence the ventricular rate if @entity2 developed.

title: Oral @entity5 fails to prevent XXXX following coronary artery surgery.

answer: @entity6


abstract: BACKGROUND: @entity4 ( @entity4 ) is established as a minimally invasive nephron-sparing technique with excellent perioperative and intermediate oncologic outcomes. However, long-term oncologic outcomes have not been reported to date. OBJECTIVE: To report long-term oncologic outcomes of @entity4 . DESIGN, SETTING, AND @entity0 : Consecutive @entity0 undergoing @entity4 from June 2006 to March 2010 were selected from our prospective @entity4 database. @entity0 with @entity1 , prior @entity5 , or prior radical nephrectomy and those with follow-up of <1 mo were excluded. INTERVENTION: Transperitoneal @entity4 . OUTCOMES MEASUREMENTS AND STATISTICAL ANALYSIS: Demographic, perioperative, and postoperative data were analyzed. Overall survival (OS), @entity1 -specific survival (CSS) were evaluated using Kaplan-Meier survival analysis. Univariate logistic regression analysis for overall mortality was performed to evaluate the odds ratio (OR) for variables of interest. RESULTS AND LIMITATIONS: In total, 115 RPNs for @entity3 were performed in 110 @entity0 . The mean age was 59.8  11.0 yr and the median age-adjusted Charlson comorbidity index (ACCI) was 4 (interquartile range [IQR] 3-5). The median @entity1 size was 2.6cm (IQR 2.0-3.7) and median RENAL score was 7 (IQR 6-9). @entity3 was present in 67.8% of cases, and two cases (1.7%) had positive surgical margins. Glomerular filtration rate preservation was 87.8% (IQR 74.9-98.1), which translates to 19.1% chronic @entity2 upstaging. The median follow-up was 61.9 mo (IQR 50.9-71.4) and the 5-yr OS, @entity1 , and CSS were 91.1%, 97.8%, and 97.8%, respectively. On univariable logistic regression, ACCI was the only factor associated with a higher risk of overall mortality (OR 1.67, p=0.006). The retrospective design, the high surgical volume at our institution, and the potential selection bias with careful @entity0 selection early in the @entity4 experience may limit the generalizability of our findings. CONCLUSIONS: This is the first study confirming excellent long-term oncologic outcomes after @entity4 in a selected cohort of @entity0 . @entity0 SUMMARY: @entity4 is a relatively recently developed treatment for @entity3 . This study confirms its safety and reports excellent long-term @entity1 control.

title: Five-year Oncologic Outcomes After Transperitoneal Robotic Partial Nephrectomy for XXXX .

answer: @entity3


abstract: This study was designed to test the effectiveness of brief relaxation training on @entity3 , replicating and extending a study of Flaherty and Fitzpatrick (1978). A two-group pre- and post-test experimental design was used to determine if vital signs, analgesic consumption, @entity1 , self-reported incisional @entity2 sensation and distress differ in postsurgical @entity0 who have or have not received relaxation training. Seventy-two adult, elective abdominal surgery @entity0 were randomly assigned to treatment groups. Subjects in both groups were visited on the eve of surgery. Experimental subjects were taught a relaxation technique. Equal time was spent with control subjects. Following surgery all subjects were observed during ambulation. Vital signs were measured pre- and postoperatively, as were self-report of @entity2 sensation and distress. Results showed that distress caused by @entity2 sensations was significantly lower for experimental subjects (F (1, 53) = 4.69, p = 0.03). Vital signs, analgesic consumption and self-reported @entity2 sensation were not altered by relaxation training. These findings only partially agree with those of Flaherty and Fitzpatrick. Additional analyses by type of surgery (cholecystectomy and hysterectomy) showed hysterectomy subjects reported less @entity2 sensation and distress and used less analgesics than cholecystectomy subjects.

title: Effects of preoperative XXXX : a replication and expansion.

answer: @entity3