abstract: UNASSIGNED: Abstract Purpose: A port-a-cath is a device implanted under the skin for continuous drug administration. It is composed of a catheter and a @entity2 or metal reservoir. A simulation study was done to assess the impact of a port-a-cath implant on the quality of superficial @entity1 treatments applied using the Lucite cone applicator (LCA). Methods: Specific absorption rate (SAR) and temperature distributions were predicted using SEMCAD-X (version 14.8). We simulated 72 arrangements: two LCA-implant set-ups (central port-a-cath or at an edge below the LCA footprint), six translations of the LCA per set-up, two LCA orientations (Parallel or perpendicular electric field direction) per set-up, two implant materials ( @entity3 or metal) and a control without port-a-cath. Treatment quality was quantified by the average 1   g SAR coverage (CV25%), i.e. volume within the 25% iso-SAR surface, and the volume within the 40     C iso-temperature surface (CV40     C). Results: CV25% reduced with a @entity3 port-a-cath located below the LCA footprint. In the worst scenario, only 64% of the CV25% of the control set-up was achieved. For a metal port-a-cath below the LCA aperture, dramatic reductions of CV25% were predicted: worst scenario down to 12.1% of the control CV25%. For the CV40     C the worst case values were 74.5% and 6.5%, for @entity3 and metal implants, respectively. Conclusions: A @entity2 port-a-cath below the LCA had a smaller effect on treatment quality than a metal implant. Based on this study we recommend verifying heating quality by 3D @entity0 -specific treatment planning when a port-a-cath is located below the footprint of the applicator.

title: Impact of @entity2 and metal port-a-cath implants on superficial XXXX treatment quality.

answer: @entity1


abstract: UNASSIGNED: The prognosis of @entity2 is mainly dependent upon chromosomal changes. The two major abnormalities driving poor outcome are the del(17p) and the t(4;14). However, the outcome of these high-risk @entity0 is not absolutely uniform, some @entity0 presenting long survival. We hypothesized that these better outcomes might be related to concomitant "good risk" chromosomal changes exploring hyperdiploidy. We analyzed a large series of 965 @entity2 @entity0 including 168 @entity0 with t(4;14) and 126 @entity0 with del(17p) using high throughput SNP arrays after plasma cell sorting. As expected, trisomic chromosomes were highly associated. Using the LASSO model, we found that only chromosome 3 when trisomic was associated with a longer progression free survival and that three trisomies modulated @entity1 ( @entity1 ) in @entity2 @entity0 : Trisomies 3 and 5 significantly improved @entity1 , and trisomy 21 worsened @entity1 . Especially in @entity0 with t(4;14), trisomies 3 and/or 5 seemed to overcome the poor prognosis. For the first time, using a specific modelling approach, we show that not all trisomies display the same prognostic impact. This finding could be important for routine assessment of prognosis in @entity2 , some high-risk @entity0 with a traditional evaluation could be in fact standard risk.

title: Understanding the role of hyperdiploidy in XXXX prognosis: which trisomies really matter?

answer: @entity2


abstract: Limbal epithelial stem cells (LESC) residing at the corneal periphery are largely responsible for maintaining corneal optical transparency by continuously supplying new corneal epithelial cells, which mature during their radial migration to the central @entity2 . @entity1 ( @entity1 ) affects all the structures of the eye including the @entity2 . Frequent @entity8 , delayed wound @entity3 , and microbial infections are common alterations of the @entity1 eye that can result in @entity5 . MicroRNAs (miRNAs) are short non-coding oligonucleotides that regulate gene expression by repressing translation. Our purpose was to understand the role of @entity7 in the @entity0 limbal versus central corneal epithelial compartment in normal and pathological conditions such as @entity1 . Using quantitative real-time PCR (QPCR) we found @entity7 enrichment in the limbal corneal compartment. This miRNA was also expressed at higher levels in the @entity1 vs. normal limbus. Cell migration and wound closure were significantly delayed in normal and @entity1 primary limbal epithelial cells (LEC) transfected with @entity7 . Cells treated with @entity7 had decreased levels of phosphorylated (activated) @entity6 and @entity4 , mediators of epithelial wound @entity3 . Conversely, inhibition of @entity7 significantly enhanced cell migration in both normal and @entity1 primary LEC and in @entity1 organ-cultured corneas by nearly 40% vs. scrambled miRNA control, accompanied by increased phosphorylated signaling intermediates. Transfection of @entity7 in cultured LEC resulted in an increased immunoreactivity for putative LEC markers Frizzled-7 and K15, whereas inhibition of @entity7 decreased their expressions. These data suggest that @entity7 plays a role in LEC maintenance at the corneal periphery, and its expression is downregulated during their migration towards the central @entity2 and accompanying terminal differentiation. Furthermore, abnormal @entity7 upregulation may be an important mechanism of delayed wound @entity1 .

title: Targeting XXXX to Treat Delayed Wound Healing in @entity0 Diabetic Organ-Cultured Corneas.

answer: @entity7


abstract: Limbal epithelial stem cells (LESC) residing at the corneal periphery are largely responsible for maintaining corneal optical transparency by continuously supplying new corneal epithelial cells, which mature during their radial migration to the central @entity2 . @entity1 ( @entity1 ) affects all the structures of the eye including the @entity2 . Frequent @entity8 , delayed wound @entity3 , and microbial infections are common alterations of the @entity1 eye that can result in @entity5 . MicroRNAs (miRNAs) are short non-coding oligonucleotides that regulate gene expression by repressing translation. Our purpose was to understand the role of @entity7 in the @entity0 limbal versus central corneal epithelial compartment in normal and pathological conditions such as @entity1 . Using quantitative real-time PCR (QPCR) we found @entity7 enrichment in the limbal corneal compartment. This miRNA was also expressed at higher levels in the @entity1 vs. normal limbus. Cell migration and wound closure were significantly delayed in normal and @entity1 primary limbal epithelial cells (LEC) transfected with @entity7 . Cells treated with @entity7 had decreased levels of phosphorylated (activated) @entity6 and @entity4 , mediators of epithelial wound @entity3 . Conversely, inhibition of @entity7 significantly enhanced cell migration in both normal and @entity1 primary LEC and in @entity1 organ-cultured corneas by nearly 40% vs. scrambled miRNA control, accompanied by increased phosphorylated signaling intermediates. Transfection of @entity7 in cultured LEC resulted in an increased immunoreactivity for putative LEC markers Frizzled-7 and K15, whereas inhibition of @entity7 decreased their expressions. These data suggest that @entity7 plays a role in LEC maintenance at the corneal periphery, and its expression is downregulated during their migration towards the central @entity2 and accompanying terminal differentiation. Furthermore, abnormal @entity7 upregulation may be an important mechanism of delayed wound @entity1 .

title: Targeting @entity7 to Treat Delayed Wound Healing in XXXX Diabetic Organ-Cultured Corneas.

answer: @entity0


abstract: UNASSIGNED: Inorganic carbon (Ci) is the major sink for photosynthetic reductant in organisms capable of oxygenic photosynthesis. In the absence of abundant Ci, the cyanobacterium @entity0 expresses a high affinity Ci acquisition system, the @entity1 ( @entity1 ), controlled by the transcriptional regulator CcmR and the metabolites NADP(+) and a-ketoglutarate, which act as co-repressors of CcmR by modulating its DNA binding. The @entity1 thus responds to internal cellular redox changes during the transition from Ci-replete to Ci-limited conditions. However, the actual changes in the metabolic state of the NADPH/NADP(+) system that occur during the transition to Ci-limited conditions remain ill-defined. Analysis of changes in the redox state of cells experiencing Ci limitation reveals systematic changes associated with physiological adjustments and a trend towards the quinone and NADP pools becoming highly reduced. A rapid and persistent increase in F0 was observed in cells reaching the Ci-limited state, as was the induction of photoprotective fluorescence quenching. Systematic changes in the fluorescence induction transients were also observed. As with Chl fluorescence, a transient reduction of the NADPH pool ('M' peak), is assigned to State 2 > State 1 transition associated with increased electron flow to NADP(+). This was followed by a characteristic decline, which was abolished by Ci limitation or inhibition of the Calvin-Benson-Bassham (CBB) cycle and is thus assigned to the activation of the CBB cycle. The results are consistent with the proposed regulation of the @entity1 and provide new information on the nature of the Chl and NADPH fluorescence induction curves.

title: Redox changes accompanying inorganic carbon limitation in XXXX .

answer: @entity0


abstract: Introduction_#8200;: Buruli @entity3 (BU) is an @entity1 caused by @entity5 . Benin, one of the most severely affected countries, notified 365  cases in 2012. This article presents the results of a psychosocial and behavioural survey conducted in the  context of a @entity2 ( @entity2 ) project with community participation. This paper  describes the diagnosis, prevention, behaviours, as well as perceptions and experiences related to BU. Methods_#8200;: A cross-sectional study was conducted in two villages (Azonme, Houedota) of Benin Atlantic department. From 15 May to 19 June 2011, a volunteer survey was conducted with 15 former @entity0 and 15 new @entity0 , selected by purposive sampling and 30 randomly selected healthy individuals. Encoding and data analysis were performed with SPSS and Excel. Results_#8200;: Respondents were aged 11 to 100 years with a mean age of 36.63 years and 55_#8200;% were @entity0 . More than 96_#8200;% of respondents were aware of BU (symptoms, mode of transmission, prevention and treatment). 20_#8200;% were familiar with the mode of transmission, but were not aware of preventive measures. Twenty-none of the 30 @entity0 or former @entity0 were treated in hospital. The attributed and perceived (including non-medical) causes of the disease were water (52), bacteria (17), @entity4 luck (5). 92_#8200;% of respondents were satisfied with the services of health professionals but proposed changes (46) concerning hospital accessibility and cost of care. Discussion_#8200;: These results show similarities and differences compared to those reported in the literature on the subject. These surveys were the basis for @entity2 interventions with the participation of two communities.

title: [Health promotion and community-based approach to Buruli XXXX : results of a psychosocial- and behavioural survey in two villages in Benin].

answer: @entity3


abstract: UNASSIGNED: The authors examined the state of @entity0 suffering from @entity6 ( @entity6 ) who endured operation for ascending @entity3 with replacement of the ascending aorta and aortic valve (Bentall operation), studying alterations of the skeleton, face, heart and eyes, as well as pathomorphological restructurings in the aortic wall. The study was carried out 7.0  4.2 years after the operation. We examined a total of 39 @entity0 with @entity6 - 27 (69.2%) @entity0 and 12 (30.8%) @entity0 aged from 22 to 70 years old (average age - 42.1  13.4 years). All @entity0 were operated on for dissecting @entity3 of the ascending aorta accompanied by a considerable degree of @entity1 or @entity5 . The mean diameter of the aorta at the level of the sinuses of Valsalva amounted to 7.0  1.3 cm (minimal - 5.0 cm, maximal - 12.0 cm), the Z-score prior to operation was 12.7  6.5. The time form making the diagnosis of @entity6 to surgical intervention for @entity4 amounted to 9.6  5.9 years. The condition after operative treatment in all @entity0 was satisfactory, with the haemodynamic indices stable: systolic AP - 133.5  19.1 mm Hg, diastolic AP 85.1  12.9 mm Hg, heart rate 74.8  7.2 bpm. The average systemic score for the symptoms and tests of @entity6 @entity0 amounted to 8.2  3.3 points. Pathohistological alterations of the aorta in @entity0 with @entity6 consisted in pronounced restructuring of the wall with deep irreversible alternative changes. The pathological process extended in the middle aortic layer all alone the length, but not only in the portions of @entity2 and dissection. The main pathomorphological signs in @entity6 were as follows: focal accumulations of mucoid substances, dystrophic alterations of smooth-muscle cells, ribbon-like anuclear zones, formation of cystlike cavities, alterations of elastic fibres - fragmentation, hyperelastosis, multiplication, thinning and straightening, zones of elastolysis.

title: [ XXXX : clinical and pathomorphological restructurings after surgical treatment of @entity4 .]

answer: @entity6


abstract: UNASSIGNED: The authors examined the state of @entity0 suffering from @entity6 ( @entity6 ) who endured operation for ascending @entity3 with replacement of the ascending aorta and aortic valve (Bentall operation), studying alterations of the skeleton, face, heart and eyes, as well as pathomorphological restructurings in the aortic wall. The study was carried out 7.0  4.2 years after the operation. We examined a total of 39 @entity0 with @entity6 - 27 (69.2%) @entity0 and 12 (30.8%) @entity0 aged from 22 to 70 years old (average age - 42.1  13.4 years). All @entity0 were operated on for dissecting @entity3 of the ascending aorta accompanied by a considerable degree of @entity1 or @entity5 . The mean diameter of the aorta at the level of the sinuses of Valsalva amounted to 7.0  1.3 cm (minimal - 5.0 cm, maximal - 12.0 cm), the Z-score prior to operation was 12.7  6.5. The time form making the diagnosis of @entity6 to surgical intervention for @entity4 amounted to 9.6  5.9 years. The condition after operative treatment in all @entity0 was satisfactory, with the haemodynamic indices stable: systolic AP - 133.5  19.1 mm Hg, diastolic AP 85.1  12.9 mm Hg, heart rate 74.8  7.2 bpm. The average systemic score for the symptoms and tests of @entity6 @entity0 amounted to 8.2  3.3 points. Pathohistological alterations of the aorta in @entity0 with @entity6 consisted in pronounced restructuring of the wall with deep irreversible alternative changes. The pathological process extended in the middle aortic layer all alone the length, but not only in the portions of @entity2 and dissection. The main pathomorphological signs in @entity6 were as follows: focal accumulations of mucoid substances, dystrophic alterations of smooth-muscle cells, ribbon-like anuclear zones, formation of cystlike cavities, alterations of elastic fibres - fragmentation, hyperelastosis, multiplication, thinning and straightening, zones of elastolysis.

title: [ @entity6 : clinical and pathomorphological restructurings after surgical treatment of XXXX .]

answer: @entity4


abstract: OBJECTIVE: To evaluate the role of the combined periodontic-orthodontic treatment in the esthetic reconstruc- tion of the anterior teeth area following periodontitis. METHODS: Thirteen adult @entity0 with @entity2 were treated. The probing @entity3 ( @entity3 ; 102 teeth, 612 sites), @entity1 on probing (102 teeth, 204 sites), papilla index (PI; 128 papillae), and papillary height (PH; 128 papillae) of each @entity0 were assessed at baseline, 3 months after the initial therapy, and the end of the orthodontic treatment. Non-parametric and paired-sample t tests were carried out for the statistical analysis of the data. RESULTS: Three months after initial therapy, the sites with @entity3  <= 3 mm accounted for 79.58% (487/612) of the observed teeth, and 88.73% (181/204) of the buccal and lingual sites of the teeth showed negative @entity1 on probing. These findings were better than those at baseline [26.31% (161/612) and 22.06% (45/204), respectively] (P < 0.05), but no sig- nificant difference was observed compared with pro-orthodontic treatment (P > 0.05). Prior to orthodontic treatment, the levels of the PI of 8 and 21 papillae were III and II, respectively, among the 128 observed papillae. After the orthodontic treatment, 51 papillae were at level III and 68 papillae were at level II. The PH of the 102 papillae was 2.84 mm    0.62 mm after ortho- dontic treatment. This result indicated significant difference compared with that of pre-orthodontic treatment (1.69 mm    0.57 mm) (P < 0.05). CONCLUSION: After initial therapy, moderate orthodontic teeth movements may reconstruct the interproximal soft tissue, with esthetic improvement of the papillary level and resolution of the periodontal defects.

title: [Esthetic reconstruction of the anterior teeth area following a combined periodontic-orthodontic treatment in adult periodontal XXXX ].

answer: @entity0


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity4 , @entity6 , @entity7 , proliferation cell nuclear antigen ( @entity3 ), Ki67 and @entity8 in @entity0 with @entity2 ( @entity2 ) by immunohistochemistry. A total of 69 @entity0 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity0 with @entity2 . Only positive expression of @entity6 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity6 (p  =  0.043), @entity3 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity0 with @entity8 reduced expression (p  =  0.022). But only @entity3 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity5 and co-expression of proteins. There was a remarkable difference between DFS or @entity5 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity8 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity2 @entity0 . These findings provide evidence that combined evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 may be a more powerful prognostic factor to predict relapse and distant @entity1 for @entity0 with @entity2 .

title: Prognostic evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 expression in XXXX .

answer: @entity2


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity4 , @entity6 , @entity7 , proliferation cell nuclear antigen ( @entity3 ), Ki67 and @entity8 in @entity0 with @entity2 ( @entity2 ) by immunohistochemistry. A total of 69 @entity0 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity0 with @entity2 . Only positive expression of @entity6 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity6 (p  =  0.043), @entity3 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity0 with @entity8 reduced expression (p  =  0.022). But only @entity3 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity5 and co-expression of proteins. There was a remarkable difference between DFS or @entity5 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity8 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity2 @entity0 . These findings provide evidence that combined evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 may be a more powerful prognostic factor to predict relapse and distant @entity1 for @entity0 with @entity2 .

title: Prognostic evaluation of XXXX , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 expression in @entity2 .

answer: @entity4


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity4 , @entity6 , @entity7 , proliferation cell nuclear antigen ( @entity3 ), Ki67 and @entity8 in @entity0 with @entity2 ( @entity2 ) by immunohistochemistry. A total of 69 @entity0 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity0 with @entity2 . Only positive expression of @entity6 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity6 (p  =  0.043), @entity3 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity0 with @entity8 reduced expression (p  =  0.022). But only @entity3 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity5 and co-expression of proteins. There was a remarkable difference between DFS or @entity5 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity8 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity2 @entity0 . These findings provide evidence that combined evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 may be a more powerful prognostic factor to predict relapse and distant @entity1 for @entity0 with @entity2 .

title: Prognostic evaluation of @entity4 , @entity6 , XXXX , @entity3 , Ki67 and @entity8 expression in @entity2 .

answer: @entity7


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity4 , @entity6 , @entity7 , proliferation cell nuclear antigen ( @entity3 ), Ki67 and @entity8 in @entity0 with @entity2 ( @entity2 ) by immunohistochemistry. A total of 69 @entity0 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity0 with @entity2 . Only positive expression of @entity6 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity6 (p  =  0.043), @entity3 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity0 with @entity8 reduced expression (p  =  0.022). But only @entity3 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity5 and co-expression of proteins. There was a remarkable difference between DFS or @entity5 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity8 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity2 @entity0 . These findings provide evidence that combined evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 may be a more powerful prognostic factor to predict relapse and distant @entity1 for @entity0 with @entity2 .

title: Prognostic evaluation of @entity4 , @entity6 , @entity7 , XXXX , Ki67 and @entity8 expression in @entity2 .

answer: @entity3


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity4 , @entity6 , @entity7 , proliferation cell nuclear antigen ( @entity3 ), Ki67 and @entity8 in @entity0 with @entity2 ( @entity2 ) by immunohistochemistry. A total of 69 @entity0 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity0 with @entity2 . Only positive expression of @entity6 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity6 (p  =  0.043), @entity3 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity0 with @entity8 reduced expression (p  =  0.022). But only @entity3 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity5 and co-expression of proteins. There was a remarkable difference between DFS or @entity5 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity8 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity2 @entity0 . These findings provide evidence that combined evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 may be a more powerful prognostic factor to predict relapse and distant @entity1 for @entity0 with @entity2 .

title: Prognostic evaluation of @entity4 , XXXX , @entity7 , @entity3 , Ki67 and @entity8 expression in @entity2 .

answer: @entity6


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity4 , @entity6 , @entity7 , proliferation cell nuclear antigen ( @entity3 ), Ki67 and @entity8 in @entity0 with @entity2 ( @entity2 ) by immunohistochemistry. A total of 69 @entity0 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity0 with @entity2 . Only positive expression of @entity6 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity6 (p  =  0.043), @entity3 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity0 with @entity8 reduced expression (p  =  0.022). But only @entity3 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity5 and co-expression of proteins. There was a remarkable difference between DFS or @entity5 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity8 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity2 @entity0 . These findings provide evidence that combined evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and @entity8 may be a more powerful prognostic factor to predict relapse and distant @entity1 for @entity0 with @entity2 .

title: Prognostic evaluation of @entity4 , @entity6 , @entity7 , @entity3 , Ki67 and XXXX expression in @entity2 .

answer: @entity8


abstract: @entity1 is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking. This study aims at improving our understanding of alveolar bone formation and the role of bone morphogenetic proteins (Bmps) in this process. @entity0 at embryonic (E) day 13.5 to @entity6 ( @entity6 ) day 15.5 were selected to observe the process of alveolar bone development. Alveolar bone development was found to be morphologically observable at E14.5. Molar teeth isolated from @entity0 at PN7.5 were pretreated with @entity4 , @entity3 , @entity5 , or BSA, and grafted subcutaneously into @entity0 . The subcutaneously implanted tooth germs formed alveolar bone indicating the role of the dental follicle in alveolar bone development. Alveolar bone formation was increased after pretreatment with @entity4 and @entity3 , but not with @entity5 . Gene expression levels in dental follicle cells from @entity0 molars were also determined by real-time RT-PCR. The expression levels of @entity2 , @entity8 , and Ocn were significantly higher in dental follicle cells cultured with @entity4 or @entity3 , and significantly lower in those cultured with @entity5 when compared with that of the BSA controls. Our results suggest that the dental follicle participates in alveolar bone formation and @entity7 appears to accelerate alveolar bone development.

title: @entity4 and XXXX accelerate alveolar bone development.

answer: @entity3


abstract: @entity1 is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking. This study aims at improving our understanding of alveolar bone formation and the role of bone morphogenetic proteins (Bmps) in this process. @entity0 at embryonic (E) day 13.5 to @entity6 ( @entity6 ) day 15.5 were selected to observe the process of alveolar bone development. Alveolar bone development was found to be morphologically observable at E14.5. Molar teeth isolated from @entity0 at PN7.5 were pretreated with @entity4 , @entity3 , @entity5 , or BSA, and grafted subcutaneously into @entity0 . The subcutaneously implanted tooth germs formed alveolar bone indicating the role of the dental follicle in alveolar bone development. Alveolar bone formation was increased after pretreatment with @entity4 and @entity3 , but not with @entity5 . Gene expression levels in dental follicle cells from @entity0 molars were also determined by real-time RT-PCR. The expression levels of @entity2 , @entity8 , and Ocn were significantly higher in dental follicle cells cultured with @entity4 or @entity3 , and significantly lower in those cultured with @entity5 when compared with that of the BSA controls. Our results suggest that the dental follicle participates in alveolar bone formation and @entity7 appears to accelerate alveolar bone development.

title: XXXX and @entity3 accelerate alveolar bone development.

answer: @entity4


abstract: OBJECTIVES: To observe the frequency of @entity0 among Saudi @entity1 and to highlight the age variations and features of @entity3 . METHODS: A retrospective study of @entity0 biopsies from all Saudi @entity1 performed between January 2006 and December 2013 in King Fahad Hospital, Al-Madinah, Kingdom of Saudi Arabia. All the available demographic and @entity3 related data was analyzed. RESULTS: Of 1005 breast tissues reviewed, 982 specimens were from female, and 23 from male @entity1 . In females, 398 specimens (40.5%) were diagnosed as malignant. @entity5 ( @entity5 ) (85.2%) was most common, followed by @entity5 in situ (8%), and @entity6 (2.7%). The mean age of Saudi females with @entity5 was 46.9 years. Approximately 48.7% @entity5 were @entity3 . A @entity3 size >2.5 cm   was found in 61.1% @entity1 , whereas axillary nodal @entity2 was present in 57.1% and lympho-vascular invasion in 64.1% who underwent axillary nodal dissection. In males, 4 specimens (17.4%) were malignant (all @entity5 ). CONCLUSION: Our finding are consistent with previous reports of @entity0 being diagnosed in younger age group, in advanced stages, and with features of @entity4 ; which signals the urgency for implementation of breast screening programs.

title: Histopathological features of XXXX in Al-Madinah region of Saudi Arabia.

answer: @entity0


abstract: OBJECTIVE: To explore the correlation between single acupoints used and the recurrence rate of @entity2 among @entity2 -prone @entity0 receiving acupuncture as a prophylactic treatment. METHODS: In all, 58 @entity2 -prone @entity0 were included in the analysis. Customised acupuncture treatments were given twice a week, over 4 weeks. The main effect parameter was the number of @entity2 episodes during the 6-month observation time. Residual urine was measured at baseline, 2, 4 and 6 months using portable ultrasound equipment. Sympathetic and vagotone nerve activities were measured by using skin conductance and respiratory sinus @entity1 , respectively. RESULTS: The main acupoints used for @entity0 with Kidney (Shen) qi/ @entity6 were Shenshu (BL23), Taixi (KI3), Zhongji (CV3), Sanyinjiao ( @entity3 ) and Pangguangshu (BL28), compared with Taichong ( @entity4 ), CV3, BL28, Yinlingquan ( @entity5 ) and @entity3 for Liver (Gan) qi stagnation, and @entity3 , CV3, BL28, Zusanli (ST36) and @entity5 for Spleen (Pi) qi/ @entity6 @entity0 . The combination BL23 and KI3 were used in 16 @entity0 , 13 of which were Kidney pattern related @entity0 . When used, the number of symptomatic episodes were reduced to a third compared with what occurred in the 42 @entity0 where this combination was not used (3/16 vs. 28/42, P<0.05). BL23 application correlated to a significant reduction in residual urine measured a few days after treatment. @entity0 with the pattern of Spleen qi/ @entity6 had an initial increase in residual urine after treatments. CONCLUSION: Treating Kidney pattern related @entity0 with the combination of BL23 and KI3 resulted in far better outcome than other points/combination of points for other Chinese medicine diagnoses. The acupoint @entity3 may be less indicated than previously assumed when treating @entity2 -prone @entity0 prophylactically.

title: Acupuncture points used in the prophylaxis against recurrent uncomplicated XXXX , patterns identified and their possible relationship to physiological measurements.

answer: @entity2


abstract: OBJECTIVE: To explore the effectiveness and safety of raltitrexed/ @entity5 with concurrent radiotherapy in treating of @entity0 with @entity2 . @entity0 AND METHODS: Sixty-five @entity0 with @entity2 enrolled in this study, received raltitrexed/ @entity5 with concurrent radiotherapy. The treatment consisted of raltitrexed 3 mg/m2 iv 15 min, d1; @entity5 60 mg/m2 iv 60 min, d1, and pelvic radiotherapy, using three-dimensional conformal radiotherapy. The radiotherapy was implemented over Elekta accelerator (Model Type Precise), with 2.0 Gy per fraction for the whole pelvic or pelvic extension field. Central lead shield was used if the dose reached 30 Gy to produce a total dosage of 50 Gy. Following radiation therapies of full pelvic field or extended-field, additional radiation with the dose of 56-60 Gy was administrated to the lymph node @entity1 . Brachytherapy of iridium 192 was completed in our hospital, with the dose of 7Gy per fraction for point A, once a week, with six fractions for internal radiations during the full treatment course of eight weeks. RESULTS: A total of 65 @entity0 completed radiotherapy with two cycles of concurrent chemotherapy. Amongst them, chemotherapy was delayed for a week due to hypoleukocytosis for seven of the @entity0 . Total response rate, three-year disease-free survival, and three-year overall survival OS were 95.4%, 75.4%, and 90.7%. High-grade (>=  3) acute @entity3 were hypoleukocytosis (23.1%) and @entity4 (6.2%) with a prevalence of high-grade (>=  3) late @entity3 at 1.5%. One @entity0 received surgical resection because of a partial @entity6 after 8 months of radiotherapy. CONCLUSIONS: Raltitrexed/ @entity5 combined with concurrent radiotherapy is effective in treating @entity2 .

title: The role of raltitrexed/ XXXX with concurrent radiation therapy in treating @entity2 .

answer: @entity5


abstract: OBJECTIVE: To explore the effectiveness and safety of raltitrexed/ @entity5 with concurrent radiotherapy in treating of @entity0 with @entity2 . @entity0 AND METHODS: Sixty-five @entity0 with @entity2 enrolled in this study, received raltitrexed/ @entity5 with concurrent radiotherapy. The treatment consisted of raltitrexed 3 mg/m2 iv 15 min, d1; @entity5 60 mg/m2 iv 60 min, d1, and pelvic radiotherapy, using three-dimensional conformal radiotherapy. The radiotherapy was implemented over Elekta accelerator (Model Type Precise), with 2.0 Gy per fraction for the whole pelvic or pelvic extension field. Central lead shield was used if the dose reached 30 Gy to produce a total dosage of 50 Gy. Following radiation therapies of full pelvic field or extended-field, additional radiation with the dose of 56-60 Gy was administrated to the lymph node @entity1 . Brachytherapy of iridium 192 was completed in our hospital, with the dose of 7Gy per fraction for point A, once a week, with six fractions for internal radiations during the full treatment course of eight weeks. RESULTS: A total of 65 @entity0 completed radiotherapy with two cycles of concurrent chemotherapy. Amongst them, chemotherapy was delayed for a week due to hypoleukocytosis for seven of the @entity0 . Total response rate, three-year disease-free survival, and three-year overall survival OS were 95.4%, 75.4%, and 90.7%. High-grade (>=  3) acute @entity3 were hypoleukocytosis (23.1%) and @entity4 (6.2%) with a prevalence of high-grade (>=  3) late @entity3 at 1.5%. One @entity0 received surgical resection because of a partial @entity6 after 8 months of radiotherapy. CONCLUSIONS: Raltitrexed/ @entity5 combined with concurrent radiotherapy is effective in treating @entity2 .

title: The role of raltitrexed/ @entity5 with concurrent radiation therapy in treating XXXX .

answer: @entity2


abstract: BACKGROUND: General practitioners (GPs) play crucial roles in early detection of @entity1 . A pilot-study found a positive short-term effect of a 1-day dermatologic education programme on GPs' diagnostic competence. OBJECTIVE: To determine effects of a multifaceted intervention, including technical equipment and continuing feedback by a dermatologist, on GPs' diagnostic skills regarding @entity1 . METHODS: Randomized controlled trial with 78 GPs of the Canton of Zurich, Switzerland. INTERVENTION: GPs in intervention group received a 1-day training, a Lumio(  ) (magnifying glass with polarized light, 3Gen), a Nikon digital camera and - during 1  year - feedback on @entity0 pictures sent to the dermatologist. GPs in control group only received the 1-day training. MAIN OUTCOME AND MEASURES: Primary outcome: structured assessment of GP's diagnostic skills in correctly diagnosing images of @entity0 regarding @entity1 . At baseline prior to intervention (T0), after the full-day training course in both groups (T1), and after 1  year of continuing feedback (T2) to the intervention group. MEASURES: Non-parametric unpaired (Wilcoxon-Mann-Whitney) tests were used to compare numbers of correctly classified @entity0 between both groups at T2 and for the change between T1 and T2. RESULTS: At T0, both groups classified a median of 23 @entity0 of the 36 images correctly. This value rose to 28 for both groups at T1 and fell to 24 for both groups at T2. No difference between control and intervention group at T2. Furthermore, we compared differences in the sum scores per GP between T1 and T2 for each group. Also in this comparison, no difference between control and intervention group was found. CONCLUSION AND RELEVANCE: No long-term effect of the multifaceted intervention was found on the competence to diagnose @entity1 by GPs. The positive short-term effect of the 1-day dermatologic education programme did not persist over 12  months.

title: A multifaceted intervention: no increase in general practitioners' competence to diagnose XXXX (minSKIN) - randomized controlled trial.

answer: @entity1


abstract: To study the influence of particle size on drug efficacy and other properties, a series of @entity2 intercalated layered double @entity6 ( @entity3 /LDHs) were synthesized through the traditional coprecipitation method, using a mixture of water and @entity1 ( @entity1 ) as the solvent. To adjust the particle size of @entity3 /LDHs, the dropping way, the volume ratio of water to @entity1 and different hydrothermal treatment time changed accordingly, and the results indicate that the particle size can be controlled between 90 and 140nm. @entity4 and inductive coupled plasma (ICP) analysis indicated that different synthesis conditions almost have no effect on the compositions of the nanohybrids. X-ray diffraction (XRD) patterns manifested the successful intercalation of @entity3 anions into the LDH interlayers, and it's also found out that different volume ratios of water to @entity1 and variable dropping way can affect the crystallinity of the final samples, i.e., the volume ratio of 3:1 and pH decreasing are proved to be optimum conditions. Furthermore, both antiparallel monolayer and bilayers adopting different orientations are suggested for four samples from XRD results. Fourier transform infrared spectroscopy (FTIR) investigations proved the coexistence of @entity5 and @entity3 anions in the interlayer of the nanohybrids. @entity3 /LDH particles exhibited hexagonal platelet morphology with round corner and different dropping ways can affect the morphology greatly. Moreover, a DSC study indicated that longer time treatment can weaken the bond between the @entity3 anions and LDH layers. The kinetic release profiles told us that larger @entity3 /LDH particles have enhanced the ability of LDH layers to protect interlayer molecules. At last, the bioassay study indicated that the nanohybrids with larger diameters have higher @entity0 suppression efficiency.

title: Facile synthesis of XXXX intercalated layered double @entity6 : Particle control, structure and bioassay explore.

answer: @entity2


abstract: To study the influence of particle size on drug efficacy and other properties, a series of @entity2 intercalated layered double @entity6 ( @entity3 /LDHs) were synthesized through the traditional coprecipitation method, using a mixture of water and @entity1 ( @entity1 ) as the solvent. To adjust the particle size of @entity3 /LDHs, the dropping way, the volume ratio of water to @entity1 and different hydrothermal treatment time changed accordingly, and the results indicate that the particle size can be controlled between 90 and 140nm. @entity4 and inductive coupled plasma (ICP) analysis indicated that different synthesis conditions almost have no effect on the compositions of the nanohybrids. X-ray diffraction (XRD) patterns manifested the successful intercalation of @entity3 anions into the LDH interlayers, and it's also found out that different volume ratios of water to @entity1 and variable dropping way can affect the crystallinity of the final samples, i.e., the volume ratio of 3:1 and pH decreasing are proved to be optimum conditions. Furthermore, both antiparallel monolayer and bilayers adopting different orientations are suggested for four samples from XRD results. Fourier transform infrared spectroscopy (FTIR) investigations proved the coexistence of @entity5 and @entity3 anions in the interlayer of the nanohybrids. @entity3 /LDH particles exhibited hexagonal platelet morphology with round corner and different dropping ways can affect the morphology greatly. Moreover, a DSC study indicated that longer time treatment can weaken the bond between the @entity3 anions and LDH layers. The kinetic release profiles told us that larger @entity3 /LDH particles have enhanced the ability of LDH layers to protect interlayer molecules. At last, the bioassay study indicated that the nanohybrids with larger diameters have higher @entity0 suppression efficiency.

title: Facile synthesis of @entity2 intercalated layered double XXXX : Particle control, structure and bioassay explore.

answer: @entity6


abstract: Different explants of fenugreek, T. foenum-graecum L. (Var. RMt-303), were compared for their callus induction and subsequent shoot regeneration capabilities on Murashige and Skoog media supplemented with different phytohormones in varying concentration. The highest percentage of callus induction frequency was observed in 1 ppm @entity9 ( @entity5 ). Maximum shoots were induced on media supplemented with 0.5 ppm BAP using leaf and stem tissues as explants. However, root tissues showed only callusing with no subsequent shooting. Cotyledonary node responded better than hypocotyls in terms of shoot induction on media supplemented with @entity8 (0.1 ppm). The callus was subjected to drought stress as simulated by reduced water potential of growth media due to addition of @entity4 . Calli could withstand -2 MPa water potential till 30 days indicating that the drought stress tolerance mechanisms are functional in this variety. Chlorophyll a and b and total @entity0 , @entity3 and total phenolic contents, total peroxidase and catalase activities increased under stress conditions suggesting the tolerance of callus to drought stress. However, @entity6 peroxidase, @entity7 peroxidase activities were found to decrease slightly. @entity2 and @entity1 contents were found to decrease while only a slight disturbance was found in membrane stability index. These results underline the mechanisms that are crucial for drought stress tolerance in fenugreek.

title: XXXX -induced drought stress on calli of Trigonellafoenum-graecum L. Var. RMt-303.

answer: @entity4


abstract: Forty-two percent of @entity1 and 58% of Enterococcus spp. isolated from @entity0 feedlot runoff and associated infiltration basin and constructed wetland treatment system were resistant to at least one antibiotic of clinical importance; a high level of multidrug resistance (22% of @entity1 and 37% of Enterococcus spp.) was observed. Hierarchical clustering revealed a closely associated resistance cluster among drug-resistant @entity1 isolates that included @entity6 (ceftiofur, cefoxitin, and @entity5 ), @entity2 ( @entity3 , @entity11 , and @entity8 ), and quinolone nalidixic acid; antibiotics from these classes were used at the study site, and cross-resistance may be associated with transferrable multiple-resistance elements. For Enterococcus spp., co-resistance among @entity4 , @entity9 , and @entity14 was common; these antibiotics are reserved for complicated clinical infections and have not been approved for animal use. @entity4 resistance (n   =   49) only occurred when isolates were resistant to @entity9 , @entity14 , and all four of the MLSB (macrolide-lincosamide-streptogramin B) antibiotics tested ( @entity12 , @entity7 , @entity10 , and quinipristin/ @entity13 ). This suggests that developing co-resistance to MLSB antibiotics along with cyclic lipopeptides and @entity15 may result in resistance to @entity4 as well. Effects of the treatment system on antibiotic resistance were pronounced during periods of no rainfall and low flow (long residence time). Increased hydraulic loading (short residence time) under the influence of rain caused antibiotic-resistant bacteria to be flushed through the treatment system. This presents concern for environmental discharge of multidrug-resistant organisms relevant to public health.

title: Hierarchal clustering yields insight into multidrug-resistant bacteria isolated from a XXXX feedlot wastewater treatment system.

answer: @entity0


abstract: BACKGROUND: Craniovertebral junction (CVJ) abnormalities constitute an important group of treatable @entity1 with diagnostic dilemma. Their precise diagnosis, identification of probable etiology, and pretreatment evaluation significantly affects prognosis and quality of life of @entity0 . AIMS: The study was to classify various @entity5 according to their etiology and to define the importance of precise diagnosis for pretreatment evaluation with multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI). MATERIALS AND METHODS: This is a prospective observational study of 62 @entity0 referred to our department between October 2012 and September 2014. All @entity0 suspected to have a @entity5 were included in the study, from all age groups and both genders. Detailed clinical history was taken. Radiographs of cervical spine were collected if available. All @entity0 were subjected to MDCT and/or MRI. RESULTS: In our study of 62 @entity0 ; 39 were males and 23 were females, with male to female ratio of 1.6:1. Most common age group was 2(nd) -3(rd) decade (19 @entity0 , 30.64%). @entity3 (33 @entity0 , 53.22%) were the most common etiology group followed by traumatic (10 @entity0 , 16.12%), degenerative (eight @entity0 , 12.90%), infective (four @entity0 , 6.45%), inflammatory and neoplastic (three @entity0 each, 4.8%), and no cause found in one @entity0 . CONCLUSIONS: CVJ abnormalities constitute an important group of treatable @entity1 , especially in certain ethnic groups and are approached with much caution by clinicians. Thus, it is essential that radiologists should be able to make a precise diagnosis of @entity2 , classify them into etiological group, and rule out important mimickers on MDCT and/or MRI, as this information ultimately helps determine the management of @entity4 , prognosis, and quality of life of @entity0 .

title: Multidetector Computed Tomography and Magnetic Resonance Imaging Evaluation of XXXX .

answer: @entity2


abstract: A proportion of elderly with @entity2 is rapidly growing. They have more severe @entity2 , therefore, derive more benefit from revascularization and have a greater need for it. The elderly is a heterogeneous group, but compared to the younger cohort, the choice of the optimal revascularization method is much more complicated among them. In recent decades, results has improved dramatically both in surgery and percutaneous coronary intervention (PCI), even in very old @entity0 . Despite the lack of evidence in elderly, it is obvious, that coronary artery bypass surgery (CABG) has a more pronounced effect on long-term survival in price of more @entity1 , while PCI is certainly less invasive. Age itself is not a criterion for the selection of treatment strategy, but the elderly are often more interested in quality of life and personal independence instead of longevity. This article discusses the factors that influence the choice of the revascularization method in the elderly with @entity3 and presents a complex algorithm for making an individual risk-benefit profile. As a consequence the features of CABG and PCI in elderly @entity0 are exposed. Emphasis is centered on the frailty and non-medical factors, including psychosocial, as essential components in making the decision of what strategy to choose. Good communication with the @entity0 and giving them unbiased information is encouraged.

title: Coronary revascularization in the elderly with XXXX .

answer: @entity3


abstract: PURPOSE: Small single-center comparative studies suggest improved outcomes in cardiac resynchronization therapy (CRT) @entity0 implanted with a quadripolar left ventricular (LV) lead in comparison with non-quadripolar ( @entity1 ) leads. This study represents the first large multicenter prospective registry comparing implant and 6-month postoperative lead performance following @entity3 ( @entity3 ) implantation with @entity1 . METHODS: During a 39-month period, 418 consecutive @entity0 having @entity3 implantation attempts with either a quadripolar (n   =   230) or @entity1 LV lead (n   =   188) were enrolled in the registry. The primary outcome of the study was LV lead failure defined as any abnormality, excluding @entity2 , resulting in surgical lead revision or CRT termination. Additionally, operative and follow-up data were analyzed for significant difference between groups. RESULTS: Baseline characteristics of both groups were similar. In 72.9  % of quadripolar leads versus 65.0  % of @entity1 leads, the LV lead successfully engaged the predefined ideal target side branch (p   =   0.47). Implant duration and fluoroscopy times were significantly shorter when a quadripolar lead was used (p   =   0.007 and p   =   0.001, respectively). The primary end point occurred in six @entity0 (2.7  %) in the quadripolar group and in 14 @entity0 (8.0  %) in the @entity1 group (p   =   0.02). Clinically significant phrenic nerve stimulation (PNS) occurred in 4.6 vs. 14.2  % of quadripolar vs. @entity1 @entity0 , respectively (p   =   0.002); all PNS were resolved noninvasively through programming in the quadripolar group vs. 84  % in @entity1 group (p   =   0.75). The use of a @entity1 was associated with a higher risk of surgical LV lead revision (6.3 vs. 2.3  %; p   =   0.057) and a higher incidence of dislodgment (5.7 vs. 2.7  %; p   =   0.16). CONCLUSIONS: This multicenter study demonstrates that the use of a quadripolar LV lead results in significantly lower rates of lead-related problems and reduced procedural and fluoroscopic times for biventricular system implantation. This has important implications for LV pacing lead choice.

title: Improved implant and postoperative lead performance in XXXX @entity0 implanted with a quadripolar left ventricular lead. A 6-month follow-up analysis from a multicenter prospective comparative study.

answer: @entity3


abstract: PURPOSE: Small single-center comparative studies suggest improved outcomes in cardiac resynchronization therapy (CRT) @entity0 implanted with a quadripolar left ventricular (LV) lead in comparison with non-quadripolar ( @entity1 ) leads. This study represents the first large multicenter prospective registry comparing implant and 6-month postoperative lead performance following @entity3 ( @entity3 ) implantation with @entity1 . METHODS: During a 39-month period, 418 consecutive @entity0 having @entity3 implantation attempts with either a quadripolar (n   =   230) or @entity1 LV lead (n   =   188) were enrolled in the registry. The primary outcome of the study was LV lead failure defined as any abnormality, excluding @entity2 , resulting in surgical lead revision or CRT termination. Additionally, operative and follow-up data were analyzed for significant difference between groups. RESULTS: Baseline characteristics of both groups were similar. In 72.9  % of quadripolar leads versus 65.0  % of @entity1 leads, the LV lead successfully engaged the predefined ideal target side branch (p   =   0.47). Implant duration and fluoroscopy times were significantly shorter when a quadripolar lead was used (p   =   0.007 and p   =   0.001, respectively). The primary end point occurred in six @entity0 (2.7  %) in the quadripolar group and in 14 @entity0 (8.0  %) in the @entity1 group (p   =   0.02). Clinically significant phrenic nerve stimulation (PNS) occurred in 4.6 vs. 14.2  % of quadripolar vs. @entity1 @entity0 , respectively (p   =   0.002); all PNS were resolved noninvasively through programming in the quadripolar group vs. 84  % in @entity1 group (p   =   0.75). The use of a @entity1 was associated with a higher risk of surgical LV lead revision (6.3 vs. 2.3  %; p   =   0.057) and a higher incidence of dislodgment (5.7 vs. 2.7  %; p   =   0.16). CONCLUSIONS: This multicenter study demonstrates that the use of a quadripolar LV lead results in significantly lower rates of lead-related problems and reduced procedural and fluoroscopic times for biventricular system implantation. This has important implications for LV pacing lead choice.

title: Improved implant and postoperative lead performance in @entity3 XXXX implanted with a quadripolar left ventricular lead. A 6-month follow-up analysis from a multicenter prospective comparative study.

answer: @entity0


abstract: BACKGROUND: Conversion (dissociative) disorder is a @entity2 in which somatic symptoms or deficits are present in the absence of a definable organic cause. The etiology of this disorder is not yet fully understood. The most characteristic presentations are: pseudosensory syndromes, pseudoseizures, @entity3 and pseudoparalysis. @entity5 is a rare form of @entity4 . The aim of present case study is to complete the knowledge on this subject. SUBJECT AND METHODS: The article presents a case of a fifty year old @entity0 who developed @entity1 of speech after being degraded to a lower position at work. After excluding organic background of observed symptoms, the diagnosis of @entity4 was stated and adequate therapy was implemented, within the capabilities of the Ward. RESULTS: Partial remission of presented symptoms was achieved as a result of psychopharmacotherapy and psychotherapy. CONCLUSIONS: Before stating the diagnosis of @entity4 , possible somatic causes of the observed symptoms should be excluded. Special attention should be drawn to the importance of studying the psychological and family context of this case and the @entity0 's difficulty to understand and accept that produced symptoms might be triggered by a psychogenic factor.

title: XXXX - a case report.

answer: @entity5


abstract: BACKGROUND: Detection of @entity3 has the potential to reduce morbidity and mortality among @entity0 and their family members due to beneficial screening and treatment options. Several institutions have begun to adopt universal rather than risk-stratified screening protocols, but the lack of 100  % compliance rates requires identification of system-level interventions to improve screening practices. OBJECTIVE: We aimed to identify @entity0 , @entity1 , and system factors associated with lack of screening and identify system-based interventions to improve @entity3 screening. DESIGN AND SETTINGS: This study is a retrospective analysis of @entity3 screening among @entity2 @entity0 undergoing surgery in a single healthcare system. @entity0 : Two hundred and sixty-two @entity0 who underwent surgery for @entity2 were studied. MAIN OUTCOME MEASURES: Rate of @entity3 screening. RESULTS: We identified that 75  % of the total cohort was screened for @entity3 . Of @entity0 under the age of 50, 78  % percent were screened. Lower screening rates were found among @entity0 with complete pathologic @entity1 response and lower pathologic stage of @entity1 . Higher screening rates were found at the academic hospital and with colorectal surgeons. In multivariable logistic regression analysis, lower screening rates were associated with community hospital location (OR, 0.22; 95  % CI, 0.08-0.56). LIMITATIONS: Results may not be generalizable to different hospital settings. CONCLUSIONS: Several potential system-level interventions were identified to improve screening rates including an emphasis on improved provider communication.

title: A Single Institution Experience in Compliance with Universal Screening for XXXX in @entity2 .

answer: @entity3


abstract: BACKGROUND: Detection of @entity3 has the potential to reduce morbidity and mortality among @entity0 and their family members due to beneficial screening and treatment options. Several institutions have begun to adopt universal rather than risk-stratified screening protocols, but the lack of 100  % compliance rates requires identification of system-level interventions to improve screening practices. OBJECTIVE: We aimed to identify @entity0 , @entity1 , and system factors associated with lack of screening and identify system-based interventions to improve @entity3 screening. DESIGN AND SETTINGS: This study is a retrospective analysis of @entity3 screening among @entity2 @entity0 undergoing surgery in a single healthcare system. @entity0 : Two hundred and sixty-two @entity0 who underwent surgery for @entity2 were studied. MAIN OUTCOME MEASURES: Rate of @entity3 screening. RESULTS: We identified that 75  % of the total cohort was screened for @entity3 . Of @entity0 under the age of 50, 78  % percent were screened. Lower screening rates were found among @entity0 with complete pathologic @entity1 response and lower pathologic stage of @entity1 . Higher screening rates were found at the academic hospital and with colorectal surgeons. In multivariable logistic regression analysis, lower screening rates were associated with community hospital location (OR, 0.22; 95  % CI, 0.08-0.56). LIMITATIONS: Results may not be generalizable to different hospital settings. CONCLUSIONS: Several potential system-level interventions were identified to improve screening rates including an emphasis on improved provider communication.

title: A Single Institution Experience in Compliance with Universal Screening for @entity3 in XXXX .

answer: @entity2


abstract: AIM: To evaluate the early and mid term results of the endovascular treatment of juxta-renal @entity2 (j-AAA) using fenestrated endograft (FEVAR). METHODS: Between 2008 to 2013 all consecutive @entity0 underwent FEVAR using Cook-Zenith fenestrated endograft for treating j-AAA (proximal neck length <5mm) with renal aortic a/b angle < 60  , were prospectively collected in a database. Cardiovascular risk factors, co-morbidities, aortic- iliac morphological features, intra and post-procedural data were analyzed. Pre-operative FEVAR planning was performed by a thoraco-abdominal computer tomography angiography (CTA) and the 3D/Center Lumen Line reconstructions (3Mensio). Follow-up was conduced by duplex ultrasound (DUS)/ contrast enhancement DUS (CEUS) and/or CTA at 1,6,12-month and yearly thereafter. Early endpoints were: technical ( @entity4 ) / clinical (CS) success, renal function worsening (>=  30% of pre- operative @entity1 value) and @entity3 . Mid term endpoints were: @entity3 , target visceral vessels patency, j-AAA shrinkage, freedom from re-intervention and survival. RESULTS: Twenty @entity0 (M: 94.7%; mean age: 73.4  5.9 years; @entity5 >= 3: 100%) were enrolled. The mean neck length and j-AAA diameter were 2    1.4mm (range: 0-4mm) and 54.9   5mm respectively. Eleven (55%) endograft with 2 fenestrations and a scallop, 8 (45%) with 3 fenestrations and a scallop and 1 (5%) with 1 fenestration and a scallop were implanted. Sixty-seven visceral vessels were re-vascularized. @entity4 and CS were 100% and 95% respectively (1/20 30-day mortality). Peri-operative renal function worsening was observed in 15% of cases. The mean follow-up was 25  20 months (range: 2-72months). No @entity3 or occlusion of target visceral vessels occurred. There was j-AAA shrinkage in 65% of @entity0 and no cases of j-AAA enlargement were observed. There were no FEVAR-related re-interventions. Survival at 12, 24 and 36 months were 89.4%, 80.5% e 80.5% respectively. CONCLUSION: According to our results, the endovascular treatment for j-AAA, with a/b angle < 60  , is safe and effective.

title: The endovascular treatment of juxta-renal XXXX using fenestrated endograft: early and mid-term results.

answer: @entity2


abstract: UNASSIGNED: Nicotinic @entity0 receptors (nAChRs) are the targets of neonicotinoids and spinosads, two insecticides used in orchards to effectively control codling moth, Cydia pomonella (L.)(Lepidoptera: Tortricidae). Orchardists in Washington State are concerned about the possibility of codling moth field populations developing resistance to these two insecticides. In an effort to help mitigate this issue, we initiated a project to identify and characterize codling moth @entity1 subunits expressed in heads. This study had two main goals; (i) identify transcripts from a codling moth head transcriptome that encode for @entity1 subunits, and (ii) determine @entity1 subunit expression profiles in various life stages of codling moth. From a codling moth head transcriptome, 24 transcripts encoding for 12 putative @entity1 subunit classes were identified and verified by PCR amplification, cloning and sequence determination. Characterization of the deduced protein sequences encoded by putative @entity1 transcripts revealed that they share the distinguishing features of the cys-loop ligand-gated ion channel superfamily with nine alpha-type subunits and three beta-type subunits identified. Phylogenetic analysis comparing these protein sequences to those of other insect @entity1 subunits supports the identification of these proteins as @entity1 subunits. Stage expression studies determined that there is clear differential expression of many of these subunits throughout the codling moth life cycle. The information from this study will be used in the future to monitor for potential target-site resistance mechanisms to neonicotinoids and spinosads in tolerant codling moth populations. This article is protected by copyright. All rights reserved.

title: Putative nicotinic XXXX receptor subunits express differentially through the life cycle of codling moth, Cydia pomonella (Lepidoptera: Tortricidae).

answer: @entity0


abstract: BACKGROUND: -Racial and ethnic minorities are underrepresented in clinical trials of primary prevention @entity1 ( @entity1 ). This analysis investigates the association between primary prevention @entity1 and mortality among Medicare, racial/ethnic minority @entity0 . METHODS AND RESULTS: -Data from Get With The Guidelines-Heart Failure Registry and National Cardiovascular Data Registry's- @entity2 Registry were used to perform an adjusted comparative effectiveness analysis of primary prevention @entity1 in Medicare, racial/ethnic minority @entity0 (non-white race or Hispanic ethnicity). Mortality data were obtained from the Medicare denominator file. The relationship of @entity2 to survival was compared between minority and white non-Hispanic @entity0 . Our analysis included 852 minority @entity0 , 426 @entity2 and 426 matched non- @entity2 @entity0 , and 2,070 white non-Hispanic @entity0 (1,035 @entity2 and 1,035 matched non- @entity2 @entity0 ). Median follow-up was 3.1 years. Median age was 73 years, and median ejection fraction was 23%. Adjusted 3-year mortality rates for minority @entity2 and non- @entity2 @entity0 were 44.9% (95% CI: 44.2-45.7%) and 54.3% (95% CI: 53.4-55.1%), respectively (adjusted HR 0.79, CI: 0.63-0.98, p=0.034). White non-Hispanic @entity0 receiving an @entity2 had lower adjusted 3-year mortality rates of 47.8% (95% CI: 47.3-48.3%) compared with 57.3% (95% CI: 56.8-57.9%) for those with no @entity2 (adjusted HR 0.75, 95% CI 0.67-0.83, p<0.0001). There was no significant interaction between race/ethnicity and lower mortality risk with @entity2 (p=0.70). CONCLUSIONS: -Primary prevention @entity1 are associated with lower mortality in non-white and Hispanic @entity0 , similar to that seen in white, non-Hispanic @entity0 . These data support a similar approach to @entity2 @entity0 selection, regardless of race or ethnicity.

title: Primary Prevention Implantable Cardioverter-Defibrillators in Older Racial and Ethnic Minority XXXX .

answer: @entity0


abstract: PURPOSE: To describe the magnetic resonance imaging (MRI) characteristics of @entity2 ( @entity2 ). MATERIALS AND METHODS: In this Institutional Review board (IRB)-approved retrospective study, 57 @entity1 were diagnosed with pathologically confirmed @entity2 during the study period (January 1999 to May 2013). Seventeen @entity1 underwent pretreatment breast MRI (prior to surgical resection or chemotherapy), of which 16 studies were available for review. Imaging features, including all available mammograms, ultrasounds, and breast MRIs, of these @entity1 were evaluated by two radiologists independently and correlated with clinical management and outcomes. RESULTS: The median age of @entity1 at original @entity0 was 69.3 years (range 42-84 years), with average time from initial radiation therapy to diagnosis of @entity2 of 7.3 years (range 5.1-9.5 years). Nine @entity1 had mammograms (9/16, 56%) and six had breast ultrasound (US) (6/16, 38%) prior to MRI, which demonstrated nonsuspicious findings in 5/9 mammograms and 3/6 ultrasounds. Four @entity1 had distinct intraparenchymal masses on mammogram and MRI. MRI findings included diffuse T2 high signal skin thickening (16/16, 100%). Nearly half (7/16, 44%) of @entity1 had T2 low signal intensity lesions; all lesions rapidly enhanced on postcontrast T1 -weighted imaging. All @entity1 underwent surgical resection, with 8/16 (50%) receiving neoadjuvant chemotherapy. Four @entity1 died during the study period. CONCLUSION: Clinical, mammographic, and sonographic findings of @entity2 are nonspecific and may be occult on conventional breast imaging; MRI findings of @entity2 include rapidly enhancing dermal and intraparenchymal lesions, some of which are low signal on T2 weighted imaging. J. Magn. Reson. Imaging 2014.

title: MRI findings of radiation-associated @entity2 ( XXXX ).

answer: @entity2


abstract: PURPOSE: To describe the magnetic resonance imaging (MRI) characteristics of @entity2 ( @entity2 ). MATERIALS AND METHODS: In this Institutional Review board (IRB)-approved retrospective study, 57 @entity1 were diagnosed with pathologically confirmed @entity2 during the study period (January 1999 to May 2013). Seventeen @entity1 underwent pretreatment breast MRI (prior to surgical resection or chemotherapy), of which 16 studies were available for review. Imaging features, including all available mammograms, ultrasounds, and breast MRIs, of these @entity1 were evaluated by two radiologists independently and correlated with clinical management and outcomes. RESULTS: The median age of @entity1 at original @entity0 was 69.3 years (range 42-84 years), with average time from initial radiation therapy to diagnosis of @entity2 of 7.3 years (range 5.1-9.5 years). Nine @entity1 had mammograms (9/16, 56%) and six had breast ultrasound (US) (6/16, 38%) prior to MRI, which demonstrated nonsuspicious findings in 5/9 mammograms and 3/6 ultrasounds. Four @entity1 had distinct intraparenchymal masses on mammogram and MRI. MRI findings included diffuse T2 high signal skin thickening (16/16, 100%). Nearly half (7/16, 44%) of @entity1 had T2 low signal intensity lesions; all lesions rapidly enhanced on postcontrast T1 -weighted imaging. All @entity1 underwent surgical resection, with 8/16 (50%) receiving neoadjuvant chemotherapy. Four @entity1 died during the study period. CONCLUSION: Clinical, mammographic, and sonographic findings of @entity2 are nonspecific and may be occult on conventional breast imaging; MRI findings of @entity2 include rapidly enhancing dermal and intraparenchymal lesions, some of which are low signal on T2 weighted imaging. J. Magn. Reson. Imaging 2014.

title: MRI findings of radiation-associated XXXX ( @entity2 ).

answer: @entity2


abstract: BACKGROUND: Occipital nerve (ON) injections with @entity2 and/or local anesthetics have been employed for the acute and preventive treatment of @entity6 for decades. However, to date there is no randomized, placebo-controlled evidence to support the use of occipital nerve block (ONB) for the prevention of @entity6 . OBJECTIVE: The objective of this article is to determine the efficacy of ONB with local anesthetic and corticosteroid for the preventive treatment of @entity6 . @entity0 AND METHODS: @entity0 between 18 and 75 years old with ICHD-II-defined episodic (> 1 attack per week) or chronic @entity6 (modified ICHD-II as @entity0 with   >   10 days with consumption of acute medications were permitted into the study) were randomized to receive either 2.5   ml 0.5% @entity3 plus 0.5   ml (20   mg) @entity5 over the ipsilateral ( @entity1 ) or bilateral ( @entity1 ) ON or 2.75   ml normal saline plus 0.25   ml 1% @entity7 without @entity4 (placebo). @entity0 completed a one-month @entity1 diary prior to and after the double-blind injection. The primary outcome measure was defined as a 50% or greater reduction in the frequency of days with moderate or severe @entity6 @entity1 in the four-week post-injection compared to the four-week pre-injection baseline period. RESULTS: Thirty-four @entity0 received active and 35 @entity0 received placebo treatment. Because of missing data, the full analysis of 33 @entity0 in the active and 30 @entity0 in the placebo group was analyzed for efficacy. In the active and placebo groups respectively, the mean frequency of at least moderate (mean 9.8 versus 9.5) and severe (3.6 versus 4.3) @entity6 days and acute medication days (7.9 versus 10.0) were not substantially different at baseline. The percentage of @entity0 with at least a 50% reduction in the frequency of moderate or severe @entity1 days was 30% for both groups (10/30 vs nine of 30,    0.00, 95% CI -0.22 to 0.23). CONCLUSIONS: Greater ONB does not reduce the frequency of moderate to severe @entity6 days in @entity0 with episodic or chronic @entity6 compared to placebo. The study was registered with ClinicalTrial.gov (NCT00915473).

title: Occipital nerve block for the short-term preventive treatment of XXXX : A randomized, double-blinded, placebo-controlled study.

answer: @entity6


abstract: Previous work has shown that endogenous chemical mediators, of which @entity1 is the prototype, increase the permeability of blood vessels by causing gaps to appear between endothelial cells. In the present paper, morphologic and statistical evidence is presented, to suggest that endothelial cells contract under the influence of mediators, and that this contraction causes the formation of intercellular gaps. @entity1 , @entity4 , and @entity5 were injected subcutaneously into the scrotum of the @entity0 , and the vessels of the underlying cremaster muscle were examined by electron microscopy. To eliminate the @entity3 induced by routine fixation, in one series of animals (including controls) the root of the cremaster was constricted for 2-4 min prior to sacrifice, and the tissues were fixed under conditions of mild @entity2 . Electron micrographs were taken of 599 nuclei from the endothelium of small blood vessels representing the various experimental situations. Nuclear deformations were classified into four types of increasing tightness (notches, foldsl closing folds, and pinches. In the latter the apposed surfaces of the nuclear membrane are in contact). It was found that: (1) @entity2 tends to straighten the nuclei in al groups; (2) mediators cause a highly significant increase in the number of pinches (P < 0.001), also if the vessels are distended by @entity2 ; (3) fixation without @entity2 causes @entity3 . The degree of endothelial recoil, as measured by nuclear pinches, is very different from that caused by mediators (P < 0.001). (4) Pinched nuclei are more frequent in leaking vessels, and in cells adjacent to gaps (P < 0.001); (5) mediators also induce, in the endothelium, cytoplasmic changes suggestive of contraction, and similar to those of contracted smooth muscle; (6) there is no evidence of pericyte contraction under the conditions tested. Occasional pericytes appeared to receive fine nerve endings. Various hypotheses to explain nuclear pinching are discussed; the only satisfactory explanation is that which requires endothelial contraction.

title: Endothelial contraction induced by XXXX -type mediators: an electron microscopic study.

answer: @entity1


abstract: UNASSIGNED: Neuroplasticity is critical for learning, memory, and recovery of lost function following @entity1 . @entity2 ( @entity2 ) techniques can induce neuroplastic changes in the @entity0 cortex that are behaviorally relevant, raising the exciting possibility that these techniques might be therapeutically beneficial for neurorehabilitation following @entity3 . However, the short duration and instability of induced effects currently limits their usefulness. To date, trials investigating the therapeutic value of neuroplasticity-inducing @entity2 have used either single or multiple treatment sessions, typically repeated once-daily for 1 to 2 weeks. Although multiple stimulation sessions are presumed to have cumulative effects on neuroplasticity induction, there is little direct scientific evidence to support this "once-daily" approach. In animal models, the repeated application of stimulation protocols spaced using relatively short intervals (typically of the order of minutes) induces long-lasting and stable changes in synaptic efficacy. Likewise, learning through spaced repetition facilitates the establishment of long-term memory. In both cases, the spacing interval is critical in determining the outcome. Emerging evidence in healthy @entity0 populations suggests that the within-session spacing of @entity2 protocols may be an effective approach for significantly prolonging the duration of induced neuroplastic changes. Similar to findings in the animal and learning literature, the interval at which spaced @entity2 is applied seems to be a critical factor influencing the neuroplastic response. In this Point of View article, we propose that to truly exploit the therapeutic opportunities provided by @entity2 , future clinical trials should consider the optimal spacing interval for repeated applications.

title: Spaced Noninvasive Brain Stimulation: Prospects for Inducing Long-Lasting XXXX Cortical Plasticity.

answer: @entity0


abstract: BACKGROUND: Most studies regarding @entity8 in @entity6 are limited to heart rate and blood pressure changes during the acute phase. However, there are few data on quantitative assessment of autonomic symptoms. We sought to assess autonomic symptoms in @entity3 @entity6 @entity0 . METHODS: In 100 @entity3 @entity0 (45 with symptomatic @entity6 (6 months after @entity1 onset) and 55 without @entity1 ), we assessed autonomic symptoms using the Scale for Outcomes in @entity4 (SCOPA-AUT). RESULTS: The age (mean  standard deviation) for the @entity1 group was 66  12 and 63  15 for the without @entity1 group (P=0.8). @entity7 occurred in 3.6% of the @entity1 group and 4.4% in the group without @entity1 . The total SCOPA-AUT score was higher in the @entity1 group compared with the group without @entity1 (P=0.001). Domain scores for gastrointestinal (P=0.001), urinary (P=0.005) and cardiovascular (P=0.001) were higher in the @entity1 group. No differences were found when comparing the total SCOPA-AUT scores for @entity1 subtypes (P=0.168) and for lateralization (P=0.6). SCOPA AUT scores were correlated with @entity5 scores (P=0.001) but not with @entity1 severity (P=0.2). CONCLUSION: Autonomic symptoms, especially, @entity2 , were significantly increased in @entity3 @entity0 with minor @entity6 . Symptoms were associated with @entity5 but not with the characteristic of the @entity1 .

title: Autonomic symptoms in XXXX @entity0 with post-acute minor @entity6 .

answer: @entity3


abstract: BACKGROUND: Most studies regarding @entity8 in @entity6 are limited to heart rate and blood pressure changes during the acute phase. However, there are few data on quantitative assessment of autonomic symptoms. We sought to assess autonomic symptoms in @entity3 @entity6 @entity0 . METHODS: In 100 @entity3 @entity0 (45 with symptomatic @entity6 (6 months after @entity1 onset) and 55 without @entity1 ), we assessed autonomic symptoms using the Scale for Outcomes in @entity4 (SCOPA-AUT). RESULTS: The age (mean  standard deviation) for the @entity1 group was 66  12 and 63  15 for the without @entity1 group (P=0.8). @entity7 occurred in 3.6% of the @entity1 group and 4.4% in the group without @entity1 . The total SCOPA-AUT score was higher in the @entity1 group compared with the group without @entity1 (P=0.001). Domain scores for gastrointestinal (P=0.001), urinary (P=0.005) and cardiovascular (P=0.001) were higher in the @entity1 group. No differences were found when comparing the total SCOPA-AUT scores for @entity1 subtypes (P=0.168) and for lateralization (P=0.6). SCOPA AUT scores were correlated with @entity5 scores (P=0.001) but not with @entity1 severity (P=0.2). CONCLUSION: Autonomic symptoms, especially, @entity2 , were significantly increased in @entity3 @entity0 with minor @entity6 . Symptoms were associated with @entity5 but not with the characteristic of the @entity1 .

title: Autonomic symptoms in @entity3 @entity0 with post-acute minor XXXX .

answer: @entity6


abstract: BACKGROUND: Most studies regarding @entity8 in @entity6 are limited to heart rate and blood pressure changes during the acute phase. However, there are few data on quantitative assessment of autonomic symptoms. We sought to assess autonomic symptoms in @entity3 @entity6 @entity0 . METHODS: In 100 @entity3 @entity0 (45 with symptomatic @entity6 (6 months after @entity1 onset) and 55 without @entity1 ), we assessed autonomic symptoms using the Scale for Outcomes in @entity4 (SCOPA-AUT). RESULTS: The age (mean  standard deviation) for the @entity1 group was 66  12 and 63  15 for the without @entity1 group (P=0.8). @entity7 occurred in 3.6% of the @entity1 group and 4.4% in the group without @entity1 . The total SCOPA-AUT score was higher in the @entity1 group compared with the group without @entity1 (P=0.001). Domain scores for gastrointestinal (P=0.001), urinary (P=0.005) and cardiovascular (P=0.001) were higher in the @entity1 group. No differences were found when comparing the total SCOPA-AUT scores for @entity1 subtypes (P=0.168) and for lateralization (P=0.6). SCOPA AUT scores were correlated with @entity5 scores (P=0.001) but not with @entity1 severity (P=0.2). CONCLUSION: Autonomic symptoms, especially, @entity2 , were significantly increased in @entity3 @entity0 with minor @entity6 . Symptoms were associated with @entity5 but not with the characteristic of the @entity1 .

title: Autonomic symptoms in @entity3 XXXX with post-acute minor @entity6 .

answer: @entity0


abstract: UNASSIGNED: Neutrophil recruitment to the site of @entity1 plays a pivotal role in host defense. Src family kinases (SFKs) activation is required for integrin and chemokine signaling as well as immune cell function. The receptor-like protein @entity4 phosphatase @entity7 positively regulates chemoattractant signaling acting on SFK activity. To further investigate the role of @entity7 in neutrophil recruitment and function, we analyzed @entity0 carrying a single point mutation (CD45 @entity9 ), which constitutively activates @entity7 . By using intravital microscopy experiments, we demonstrated that different steps of the leukocyte recruitment cascade were affected in CD45E613R mutant @entity0 . The rolling velocity of CD45 @entity9 mutant neutrophils was decreased compared with wild-type neutrophils that subsequently resulted in an increased number of adherent cells. The analysis of b2 integrins @entity8 and @entity6 ( @entity6 ) showed that in CD45 @entity9 mutant neutrophils @entity8 @entity5 was impaired, and avidity was enhanced, whereas @entity6 @entity5 was increased. Because of the increased @entity6 @entity5 , neutrophil crawling was impaired in CD45E613R mutant compared with wild-type neutrophils. In an @entity3 @entity2 model, CD45E613R @entity0 displayed a decreased neutrophil recruitment into the alveolar compartment, which resulted in an increased number of CFUs in the lung. Our data demonstrate that the CD45 @entity9 mutation modulates integrin activation and leukocyte recruitment during @entity1 .

title: Mutation in the XXXX Inhibitory Wedge Modulates Integrin Activation and Leukocyte Recruitment during @entity1 .

answer: @entity7


abstract: UNASSIGNED: Neutrophil recruitment to the site of @entity1 plays a pivotal role in host defense. Src family kinases (SFKs) activation is required for integrin and chemokine signaling as well as immune cell function. The receptor-like protein @entity4 phosphatase @entity7 positively regulates chemoattractant signaling acting on SFK activity. To further investigate the role of @entity7 in neutrophil recruitment and function, we analyzed @entity0 carrying a single point mutation (CD45 @entity9 ), which constitutively activates @entity7 . By using intravital microscopy experiments, we demonstrated that different steps of the leukocyte recruitment cascade were affected in CD45E613R mutant @entity0 . The rolling velocity of CD45 @entity9 mutant neutrophils was decreased compared with wild-type neutrophils that subsequently resulted in an increased number of adherent cells. The analysis of b2 integrins @entity8 and @entity6 ( @entity6 ) showed that in CD45 @entity9 mutant neutrophils @entity8 @entity5 was impaired, and avidity was enhanced, whereas @entity6 @entity5 was increased. Because of the increased @entity6 @entity5 , neutrophil crawling was impaired in CD45E613R mutant compared with wild-type neutrophils. In an @entity3 @entity2 model, CD45E613R @entity0 displayed a decreased neutrophil recruitment into the alveolar compartment, which resulted in an increased number of CFUs in the lung. Our data demonstrate that the CD45 @entity9 mutation modulates integrin activation and leukocyte recruitment during @entity1 .

title: Mutation in the @entity7 Inhibitory Wedge Modulates Integrin Activation and Leukocyte Recruitment during XXXX .

answer: @entity1


abstract: UNASSIGNED: Neural stem cell (NSC)-based carriers have been presented as promising therapeutic tools for the treatment of infiltrative @entity5 due to their intrinsic @entity0 homing property. They have demonstrated the ability to migrate towards distant @entity0 microsatellites and effectively deliver the therapeutic payload, thus significantly improving survival in experimental animal models for @entity5 . Despite such optimistic results, the efficacy of NSC-based anti- @entity0 therapy has been limited due to the restricted @entity0 homing ability of NSCs. To examine this issue, we investigated the mechanisms of @entity0 -tropic migration of an FDA-approved NSC line, @entity8 .F3. @entity4 , by performing a gene expression analysis. We identified @entity1 ( @entity1 ) and membrane-bound matrix metalloproteinase ( @entity6 ) as molecules whose expression are significantly elevated in migratory NSCs. We observed increased expression of @entity3 ( @entity3 ) in the focal adhesion complexes of migratory NSCs, with downstream activation of @entity3 -dependent kinases such as p-PLCy, p- @entity7 , and p-Akt, a signaling cascade reported to be required for cellular migration. In an in vivo @entity2 xenograft model, analysis of the migratory trail showed that NSCs maintained expression of @entity3 and preferentially migrated within the perivascular space. Knockdown of @entity3 via shRNAs led to significant downregulation of @entity6 expression, which resulted in inhibited @entity0 -tropic migration. Overall, our results suggest, the involvement of @entity3 -regulated @entity6 in the @entity0 -tropic migratory behavior of NSCs. Our data warrant investigation of @entity6 as a target for enhancing the migratory properties of NSC carriers and optimizing the delivery of therapeutic payloads to disseminated @entity0 burdens.

title: XXXX as a novel downstream target of @entity3 in @entity2 -tropic neural stem cells.

answer: @entity6


abstract: UNASSIGNED: Neural stem cell (NSC)-based carriers have been presented as promising therapeutic tools for the treatment of infiltrative @entity5 due to their intrinsic @entity0 homing property. They have demonstrated the ability to migrate towards distant @entity0 microsatellites and effectively deliver the therapeutic payload, thus significantly improving survival in experimental animal models for @entity5 . Despite such optimistic results, the efficacy of NSC-based anti- @entity0 therapy has been limited due to the restricted @entity0 homing ability of NSCs. To examine this issue, we investigated the mechanisms of @entity0 -tropic migration of an FDA-approved NSC line, @entity8 .F3. @entity4 , by performing a gene expression analysis. We identified @entity1 ( @entity1 ) and membrane-bound matrix metalloproteinase ( @entity6 ) as molecules whose expression are significantly elevated in migratory NSCs. We observed increased expression of @entity3 ( @entity3 ) in the focal adhesion complexes of migratory NSCs, with downstream activation of @entity3 -dependent kinases such as p-PLCy, p- @entity7 , and p-Akt, a signaling cascade reported to be required for cellular migration. In an in vivo @entity2 xenograft model, analysis of the migratory trail showed that NSCs maintained expression of @entity3 and preferentially migrated within the perivascular space. Knockdown of @entity3 via shRNAs led to significant downregulation of @entity6 expression, which resulted in inhibited @entity0 -tropic migration. Overall, our results suggest, the involvement of @entity3 -regulated @entity6 in the @entity0 -tropic migratory behavior of NSCs. Our data warrant investigation of @entity6 as a target for enhancing the migratory properties of NSC carriers and optimizing the delivery of therapeutic payloads to disseminated @entity0 burdens.

title: @entity6 as a novel downstream target of XXXX in @entity2 -tropic neural stem cells.

answer: @entity3


abstract: UNASSIGNED: Neural stem cell (NSC)-based carriers have been presented as promising therapeutic tools for the treatment of infiltrative @entity5 due to their intrinsic @entity0 homing property. They have demonstrated the ability to migrate towards distant @entity0 microsatellites and effectively deliver the therapeutic payload, thus significantly improving survival in experimental animal models for @entity5 . Despite such optimistic results, the efficacy of NSC-based anti- @entity0 therapy has been limited due to the restricted @entity0 homing ability of NSCs. To examine this issue, we investigated the mechanisms of @entity0 -tropic migration of an FDA-approved NSC line, @entity8 .F3. @entity4 , by performing a gene expression analysis. We identified @entity1 ( @entity1 ) and membrane-bound matrix metalloproteinase ( @entity6 ) as molecules whose expression are significantly elevated in migratory NSCs. We observed increased expression of @entity3 ( @entity3 ) in the focal adhesion complexes of migratory NSCs, with downstream activation of @entity3 -dependent kinases such as p-PLCy, p- @entity7 , and p-Akt, a signaling cascade reported to be required for cellular migration. In an in vivo @entity2 xenograft model, analysis of the migratory trail showed that NSCs maintained expression of @entity3 and preferentially migrated within the perivascular space. Knockdown of @entity3 via shRNAs led to significant downregulation of @entity6 expression, which resulted in inhibited @entity0 -tropic migration. Overall, our results suggest, the involvement of @entity3 -regulated @entity6 in the @entity0 -tropic migratory behavior of NSCs. Our data warrant investigation of @entity6 as a target for enhancing the migratory properties of NSC carriers and optimizing the delivery of therapeutic payloads to disseminated @entity0 burdens.

title: @entity6 as a novel downstream target of @entity3 in XXXX -tropic neural stem cells.

answer: @entity2


abstract: OBJECTIVES: To retrospectively evaluate the value of CT for @entity3 ( @entity3 ) staging in @entity2 . METHODS: Two uroradiologists reviewed CT scans of 231 @entity0 who underwent radical cystectomy and pelvic lymphadenectomy according to a predefined 12-field template. A 5-step model was used to grade the radiological likelihood of a @entity3 to represent malignant spread based on size, configuration and structure as well as regional clustering. Statistical analyses were performed both on @entity0 - and field-based levels. RESULTS: @entity3 metastases were found in 59 of 231 @entity0 (25.5%). On a @entity0 -based level, sensitivity, specificity, positive predictive value ( @entity4 ), negative predictive value (NPV) and accuracy were 52.6, 93.6, 73.2, 85.6 and 83.4%, respectively. Using the field-based approach, a total of 1,649 anatomical fields were evaluable, of which 114 fields showed @entity1 (6.9%). On a field basis, sensitivity, specificity, @entity4 , NPV and accuracy were 30.2, 98, 51.5, 94.5 and 93.3%, respectively. Concerning local staging (pT category), the overall accuracy was 78%; overstaging occurred in 6% and understaging in 16%. CONCLUSIONS: In line with prior studies, the sensitivity of CT imaging for the detection of @entity3 metastases was low, while high values for specificity were achieved. This was further underlined by analyzing standardized anatomical fields. Concerning local staging, postoperative changes after TURB-T rarely led to overstaging.

title: Evaluation of Computed Tomography for Lymph Node Staging in XXXX Prior to Radical Cystectomy.

answer: @entity2


abstract: Purpose: @entity5 ( @entity5 ) is part of the VEGF family and is known to be involved in angiogenesis, vasopermeability, and neuroprotection. Recently, @entity5 has been reported as a novel therapeutic target for wet @entity4 . However, there are few reports about the effect of @entity5 against dry @entity4 . Previously, we reported that @entity5 has protective effects against retinal neuronal cell damage in vitro. Therefore, we investigated the effects of @entity5 against @entity1 . Methods: In this study, @entity0 were exposed to white light at 8000 lx for 3 hours to induce @entity2 , which was evaluated by recording the electroretinogram amplitude and measuring the outer nuclear layer (ONL) thickness. The @entity0 were injected intravitreally with @entity5 before light exposure, @entity5 after light exposure, or anti- @entity5 antibody before light exposure. RPE-choroid-sclera flat mounts were immunostained with anti-ZO-1 antibody to evaluate the disruption of retinal pigmented epithelium (RPE) cell-cell junctional integrity after light exposure. Furthermore, the expression of VEGF receptor in the retina and RPE-choroid complex after light exposure was measured using Western blot analysis. Results: Contrary to the expected outcome, @entity5 treatment exacerbated the light-induced @entity2 and ONL thinning. In contrast, anti- @entity5 treatment significantly improved the light-induced @entity3 . The disruption of RPE cell-cell junctional integrity after light exposure was suppressed by anti- @entity5 treatment. Moreover, the VEGF receptor, which is involved in blood-retinal barrier breakdown, was up-regulated after light exposure. Conclusions: These findings suggest that anti- @entity5 antibody has protective effects against light-induced @entity3 in the @entity0 retina through inhibition of RPE breakdown after light exposure. Thus, anti- @entity5 antibody may be useful therapeutic agents in dry @entity4 .

title: Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced XXXX in @entity0 .

answer: @entity2


abstract: Purpose: @entity5 ( @entity5 ) is part of the VEGF family and is known to be involved in angiogenesis, vasopermeability, and neuroprotection. Recently, @entity5 has been reported as a novel therapeutic target for wet @entity4 . However, there are few reports about the effect of @entity5 against dry @entity4 . Previously, we reported that @entity5 has protective effects against retinal neuronal cell damage in vitro. Therefore, we investigated the effects of @entity5 against @entity1 . Methods: In this study, @entity0 were exposed to white light at 8000 lx for 3 hours to induce @entity2 , which was evaluated by recording the electroretinogram amplitude and measuring the outer nuclear layer (ONL) thickness. The @entity0 were injected intravitreally with @entity5 before light exposure, @entity5 after light exposure, or anti- @entity5 antibody before light exposure. RPE-choroid-sclera flat mounts were immunostained with anti-ZO-1 antibody to evaluate the disruption of retinal pigmented epithelium (RPE) cell-cell junctional integrity after light exposure. Furthermore, the expression of VEGF receptor in the retina and RPE-choroid complex after light exposure was measured using Western blot analysis. Results: Contrary to the expected outcome, @entity5 treatment exacerbated the light-induced @entity2 and ONL thinning. In contrast, anti- @entity5 treatment significantly improved the light-induced @entity3 . The disruption of RPE cell-cell junctional integrity after light exposure was suppressed by anti- @entity5 treatment. Moreover, the VEGF receptor, which is involved in blood-retinal barrier breakdown, was up-regulated after light exposure. Conclusions: These findings suggest that anti- @entity5 antibody has protective effects against light-induced @entity3 in the @entity0 retina through inhibition of RPE breakdown after light exposure. Thus, anti- @entity5 antibody may be useful therapeutic agents in dry @entity4 .

title: Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced @entity2 in XXXX .

answer: @entity0