abstract: BACKGROUND: @entity0 is generally defined as a @entity5 state resulting from peripheral and/or central @entity2 . There is a lack of effective treatment for @entity0 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity8 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity5 induced by peripheral administration of inflammatory agents such as @entity4 . In this study, we aimed to show the effect of @entity8 on @entity3 behavior and serum @entity7 level in a @entity9 ( @entity9 ) model of @entity0 . METHODS: @entity1 male @entity1 (150-200 g, n = 8) were divided into three groups: @entity9 vehicle-treated, sham-operated, and @entity9 drug-treated group. @entity8 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity7 level was measured on day 7 after the surgery. RESULTS: @entity8 (50 mg/kg) decreased mechanical and cold @entity6 (P < 0.001) and produced a decline in serum @entity7 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity3 behavior and serum @entity7 levels was seen in @entity1 following administration of @entity8 in @entity9 model of @entity0 . High concentration of @entity8 was able to reduce the chronic @entity0 induced by @entity9 model and the serum level of @entity7 .

title: The Attenuation of Pain Behavior and Serum @entity7 Concentration by @entity8 in a @entity1 Model of XXXX .

answer: @entity0


abstract: BACKGROUND: @entity0 is generally defined as a @entity5 state resulting from peripheral and/or central @entity2 . There is a lack of effective treatment for @entity0 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity8 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity5 induced by peripheral administration of inflammatory agents such as @entity4 . In this study, we aimed to show the effect of @entity8 on @entity3 behavior and serum @entity7 level in a @entity9 ( @entity9 ) model of @entity0 . METHODS: @entity1 male @entity1 (150-200 g, n = 8) were divided into three groups: @entity9 vehicle-treated, sham-operated, and @entity9 drug-treated group. @entity8 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity7 level was measured on day 7 after the surgery. RESULTS: @entity8 (50 mg/kg) decreased mechanical and cold @entity6 (P < 0.001) and produced a decline in serum @entity7 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity3 behavior and serum @entity7 levels was seen in @entity1 following administration of @entity8 in @entity9 model of @entity0 . High concentration of @entity8 was able to reduce the chronic @entity0 induced by @entity9 model and the serum level of @entity7 .

title: The Attenuation of Pain Behavior and Serum XXXX Concentration by @entity8 in a @entity1 Model of @entity0 .

answer: @entity7


abstract: BACKGROUND: @entity0 is generally defined as a @entity5 state resulting from peripheral and/or central @entity2 . There is a lack of effective treatment for @entity0 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity8 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity5 induced by peripheral administration of inflammatory agents such as @entity4 . In this study, we aimed to show the effect of @entity8 on @entity3 behavior and serum @entity7 level in a @entity9 ( @entity9 ) model of @entity0 . METHODS: @entity1 male @entity1 (150-200 g, n = 8) were divided into three groups: @entity9 vehicle-treated, sham-operated, and @entity9 drug-treated group. @entity8 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity7 level was measured on day 7 after the surgery. RESULTS: @entity8 (50 mg/kg) decreased mechanical and cold @entity6 (P < 0.001) and produced a decline in serum @entity7 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity3 behavior and serum @entity7 levels was seen in @entity1 following administration of @entity8 in @entity9 model of @entity0 . High concentration of @entity8 was able to reduce the chronic @entity0 induced by @entity9 model and the serum level of @entity7 .

title: The Attenuation of Pain Behavior and Serum @entity7 Concentration by XXXX in a @entity1 Model of @entity0 .

answer: @entity8


abstract: BACKGROUND: @entity0 is generally defined as a @entity5 state resulting from peripheral and/or central @entity2 . There is a lack of effective treatment for @entity0 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity8 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity5 induced by peripheral administration of inflammatory agents such as @entity4 . In this study, we aimed to show the effect of @entity8 on @entity3 behavior and serum @entity7 level in a @entity9 ( @entity9 ) model of @entity0 . METHODS: @entity1 male @entity1 (150-200 g, n = 8) were divided into three groups: @entity9 vehicle-treated, sham-operated, and @entity9 drug-treated group. @entity8 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity7 level was measured on day 7 after the surgery. RESULTS: @entity8 (50 mg/kg) decreased mechanical and cold @entity6 (P < 0.001) and produced a decline in serum @entity7 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity3 behavior and serum @entity7 levels was seen in @entity1 following administration of @entity8 in @entity9 model of @entity0 . High concentration of @entity8 was able to reduce the chronic @entity0 induced by @entity9 model and the serum level of @entity7 .

title: The Attenuation of Pain Behavior and Serum @entity7 Concentration by @entity8 in a XXXX Model of @entity0 .

answer: @entity1


abstract: PURPOSE: It is known that antiepileptic drugs might adversely affect neuronal function and thus influence brain development. However, we have reported that @entity2 are one of the most prominent disturbances caused by @entity3 ( @entity4 ) in the developing embryo. The aim of this work is to gain a better understanding of possible molecular mechanisms behind the @entity1 and @entity2 associated with @entity4 . METHODS: Pregnant @entity0 divided into four groups. Each @entity0 received an intraperitoneal injection (IP) of 0, 20 (group I), 40 (group II) or 80 (group III) mg/kg/day of @entity4 during the organogenesis period. On gestational day 18, embryos were separated and their limbs were dissected. Levels of apoptotic proteins were analyzed by Western blotting. To establish whether apoptosis is present in the limbs, the specimens were examined by TUNEL. Pathological findings were also reported as a score ranging from 1 to 3 based on the level of differentiation. RESULTS: Western blot analysis demonstrated that @entity4 in all @entity4 -treated groups significantly upregulated the levels of cleaved caspase-3, 8 and 9. Also, the results showed that @entity4 exposure increased the percentage of TUNEL positive cells in different limb tissues especially the mesenchymal tissue. The histopathological findings revealed that @entity4 administration to pregnant @entity0 inhibited limb tissue differentiation, albeit to varying degrees. CONCLUSIONS: The result of our study revealed that apoptosis and inhibition of limb tissue differentiation play an important role in the pathogenesis of @entity4 -induced @entity2 . Both intrinsic and extrinsic caspase-dependent pathways of cell death are important in mediating the abnormal limb development triggered by insult with the @entity4 . Evaluating the effect of @entity4 on molecules involved in the cross-talk between intrinsic and extrinsic apoptotic pathways and cell adhesion, migration, proliferation, and differentiation during embryonic development can further help to identify and clarify the involved mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

title: Pathogenesis of XXXX -Induced @entity2 in @entity0 Embryos.

answer: @entity3


abstract: PURPOSE: It is known that antiepileptic drugs might adversely affect neuronal function and thus influence brain development. However, we have reported that @entity2 are one of the most prominent disturbances caused by @entity3 ( @entity4 ) in the developing embryo. The aim of this work is to gain a better understanding of possible molecular mechanisms behind the @entity1 and @entity2 associated with @entity4 . METHODS: Pregnant @entity0 divided into four groups. Each @entity0 received an intraperitoneal injection (IP) of 0, 20 (group I), 40 (group II) or 80 (group III) mg/kg/day of @entity4 during the organogenesis period. On gestational day 18, embryos were separated and their limbs were dissected. Levels of apoptotic proteins were analyzed by Western blotting. To establish whether apoptosis is present in the limbs, the specimens were examined by TUNEL. Pathological findings were also reported as a score ranging from 1 to 3 based on the level of differentiation. RESULTS: Western blot analysis demonstrated that @entity4 in all @entity4 -treated groups significantly upregulated the levels of cleaved caspase-3, 8 and 9. Also, the results showed that @entity4 exposure increased the percentage of TUNEL positive cells in different limb tissues especially the mesenchymal tissue. The histopathological findings revealed that @entity4 administration to pregnant @entity0 inhibited limb tissue differentiation, albeit to varying degrees. CONCLUSIONS: The result of our study revealed that apoptosis and inhibition of limb tissue differentiation play an important role in the pathogenesis of @entity4 -induced @entity2 . Both intrinsic and extrinsic caspase-dependent pathways of cell death are important in mediating the abnormal limb development triggered by insult with the @entity4 . Evaluating the effect of @entity4 on molecules involved in the cross-talk between intrinsic and extrinsic apoptotic pathways and cell adhesion, migration, proliferation, and differentiation during embryonic development can further help to identify and clarify the involved mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

title: Pathogenesis of @entity3 -Induced XXXX in @entity0 Embryos.

answer: @entity2


abstract: PURPOSE: It is known that antiepileptic drugs might adversely affect neuronal function and thus influence brain development. However, we have reported that @entity2 are one of the most prominent disturbances caused by @entity3 ( @entity4 ) in the developing embryo. The aim of this work is to gain a better understanding of possible molecular mechanisms behind the @entity1 and @entity2 associated with @entity4 . METHODS: Pregnant @entity0 divided into four groups. Each @entity0 received an intraperitoneal injection (IP) of 0, 20 (group I), 40 (group II) or 80 (group III) mg/kg/day of @entity4 during the organogenesis period. On gestational day 18, embryos were separated and their limbs were dissected. Levels of apoptotic proteins were analyzed by Western blotting. To establish whether apoptosis is present in the limbs, the specimens were examined by TUNEL. Pathological findings were also reported as a score ranging from 1 to 3 based on the level of differentiation. RESULTS: Western blot analysis demonstrated that @entity4 in all @entity4 -treated groups significantly upregulated the levels of cleaved caspase-3, 8 and 9. Also, the results showed that @entity4 exposure increased the percentage of TUNEL positive cells in different limb tissues especially the mesenchymal tissue. The histopathological findings revealed that @entity4 administration to pregnant @entity0 inhibited limb tissue differentiation, albeit to varying degrees. CONCLUSIONS: The result of our study revealed that apoptosis and inhibition of limb tissue differentiation play an important role in the pathogenesis of @entity4 -induced @entity2 . Both intrinsic and extrinsic caspase-dependent pathways of cell death are important in mediating the abnormal limb development triggered by insult with the @entity4 . Evaluating the effect of @entity4 on molecules involved in the cross-talk between intrinsic and extrinsic apoptotic pathways and cell adhesion, migration, proliferation, and differentiation during embryonic development can further help to identify and clarify the involved mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

title: Pathogenesis of @entity3 -Induced @entity2 in XXXX Embryos.

answer: @entity0


abstract: UNASSIGNED: Based on the recently proposed Chinese @entity3 (CISS) system, intracranial branch @entity2 (BAD) is divided into large artery @entity5 (LAA) and @entity4 ( @entity4 ). In the current retrospective analysis, we compared the general characteristics of BAD-LAA with BAD- @entity4 , BAD-LAA with non-BAD-LAA and BAD- @entity4 with non-BAD- @entity4 . The study included a total of 80 cases, including 45 cases of BAD and 35 cases of non-BAD. Subjects were classified using CISS system: BAD-LAA, BAD- @entity4 , non-BAD-LAA and non-BAD- @entity4 . In addition to analysis of general characteristics, the correlation between the factors and the two subtypes of BAD was evaluated. The number of cases included in the analysis was: 32 cases of BAD-LAA, 13 cases of BAD- @entity4 , 21 cases of non-BAD-LAA, and 14 cases of non-BAD- @entity4 . @entity1 affected more non-BAD-LAA @entity0 than BAD-LAA @entity0 (P=0.035). In comparison with non-BAD- @entity4 , @entity0 with BAD- @entity4 were younger (P=0.040), had higher initial NIHSS score (P<0.001) and morbidity of @entity6 (P=0.033). Within @entity0 with BAD, the @entity4 subtype was associated with smoking (OR=0.043; P=0.011), higher low-density lipoprotein (OR=5.339; P=0.029), @entity6 (OR=9.383; P=0.047) and @entity1 (OR=12.59; P=0.020). It was concluded that large artery @entity5 was the primary mechanism of BAD. The general characteristics showed no significant differences between the CISS subtypes of LAA and @entity4 within BAD, as well as between the BAD and non-BAD within LAA subtype. Several differences between @entity4 subtypes of BAD and non-BAD were revealed.

title: Comparative analysis of general characteristics of XXXX of BAD and non-BAD CISS subtypes.

answer: @entity3


abstract: Purpose. We present a case with @entity9 that had unilateral mature @entity2 and @entity5 . Case Report. A 17-year-old @entity0 with @entity9 presented to the clinic of ophthalmology for @entity8 in the right eye. His best corrected visual acuity (BCVA) was hand motion in the right eye and 20/20 in the left eye. Anterior segment examination revealed mature @entity2 in the right. During the physical examination, @entity7 were noted over right side of his face, ankle, and toes. He had asymmetric face and his head was larger on the right side. Leg lengths were symmetrical, although he had @entity3 . Cranial magnetic resonance imaging studies showed @entity1 discordant to his age, asymmetric vascular dilatations in the right hemisphere, @entity4 in the right periorbital soft tissue, and choroidal plexus. The @entity0 received an uncomplicated @entity2 surgery. His BCVA in the right eye improved to 20/200 after the surgery. After removing cataractous lens, we were able to examine the fundus that revealed severe @entity5 and @entity6 . Conclusion. This case emphasizes the importance of prompt ophthalmic examination in @entity0 with @entity9 .

title: @entity2 and XXXX in a case with @entity9 .

answer: @entity5


abstract: Purpose. We present a case with @entity9 that had unilateral mature @entity2 and @entity5 . Case Report. A 17-year-old @entity0 with @entity9 presented to the clinic of ophthalmology for @entity8 in the right eye. His best corrected visual acuity (BCVA) was hand motion in the right eye and 20/20 in the left eye. Anterior segment examination revealed mature @entity2 in the right. During the physical examination, @entity7 were noted over right side of his face, ankle, and toes. He had asymmetric face and his head was larger on the right side. Leg lengths were symmetrical, although he had @entity3 . Cranial magnetic resonance imaging studies showed @entity1 discordant to his age, asymmetric vascular dilatations in the right hemisphere, @entity4 in the right periorbital soft tissue, and choroidal plexus. The @entity0 received an uncomplicated @entity2 surgery. His BCVA in the right eye improved to 20/200 after the surgery. After removing cataractous lens, we were able to examine the fundus that revealed severe @entity5 and @entity6 . Conclusion. This case emphasizes the importance of prompt ophthalmic examination in @entity0 with @entity9 .

title: XXXX and @entity5 in a case with @entity9 .

answer: @entity2


abstract: Purpose. We present a case with @entity9 that had unilateral mature @entity2 and @entity5 . Case Report. A 17-year-old @entity0 with @entity9 presented to the clinic of ophthalmology for @entity8 in the right eye. His best corrected visual acuity (BCVA) was hand motion in the right eye and 20/20 in the left eye. Anterior segment examination revealed mature @entity2 in the right. During the physical examination, @entity7 were noted over right side of his face, ankle, and toes. He had asymmetric face and his head was larger on the right side. Leg lengths were symmetrical, although he had @entity3 . Cranial magnetic resonance imaging studies showed @entity1 discordant to his age, asymmetric vascular dilatations in the right hemisphere, @entity4 in the right periorbital soft tissue, and choroidal plexus. The @entity0 received an uncomplicated @entity2 surgery. His BCVA in the right eye improved to 20/200 after the surgery. After removing cataractous lens, we were able to examine the fundus that revealed severe @entity5 and @entity6 . Conclusion. This case emphasizes the importance of prompt ophthalmic examination in @entity0 with @entity9 .

title: @entity2 and @entity5 in a case with XXXX .

answer: @entity9


abstract: UNASSIGNED: @entity4 ( @entity4 ) is a rare @entity2 for which there are limited treatment options due to a poor understanding of the molecular alterations underlying disease development and progression. Therefore, we performed comprehensive, targeted next-generation sequencing to identify relevant somatic genomic alterations in a retrospective cohort of 60 fixed @entity2 samples from 43 @entity4 cases (including 14 matched primary/ @entity1 pairs). We identified a median of two relevant somatic mutations and one high-level copy-number alteration per sample (range, 0-5 and 0-6, respectively). Expression of HPV and @entity5 was detectable in 12% and 28% of @entity0 , respectively. Furthermore, advanced clinical stage, lack of @entity5 expression, and MYC and @entity6 amplifications were significantly associated with shorter time to progression or @entity4 -specific survival. Notably, four cases harbored @entity3 amplifications and one demonstrated @entity8 amplification, genes for which approved and investigational targeted therapies are available. Importantly, although paired @entity2 and lymph node @entity1 were largely homogeneous for relevant somatic mutations, we identified heterogeneous @entity3 amplification in primary @entity2 /lymph node @entity1 in 4 of 14 cases, despite uniform @entity3 protein overexpression. Likewise, activating @entity7 mutations occurred in 8 of 43 cases. Taken together, we provide the first comprehensive molecular @entity4 analysis, which offers new insight into potential precision medicine approaches for this disease, including strategies targeting @entity3 . @entity2 Res; 75(24); 5219-27.   2015 AACR.

title: Genomic Profiling of XXXX Reveals New Opportunities for Targeted Therapy.

answer: @entity4


abstract: A pregnant @entity0 presented with acute upper @entity3 and @entity1 at 15 weeks' gestation. She had a history of cesarean delivery for abruption after the removal of a Shirodkar cerclage that was placed because of cervical @entity6 caused by conization. She became pregnant again 14 months later. Ultrasonography revealed no significant findings, and a single intrauterine pregnancy with positive fetal heart activity was confirmed. An @entity5 was suspected because abdominal radiography showed multiple air-fluid levels in the colon. Over the 3 hours following admission, her symptoms gradually worsened, and plain abdominal computed tomography (CT) showed a large @entity4 in the abdominal cavity, but the uterine wall appeared intact at this time. Subsequently, dynamic CT revealed discontinuity of the uterine muscle layer. During laparotomy, uterine @entity2 with complete opening of the uterine wall at the site of the previous transverse scar was identified. A dead fetus was located within the amniotic sac in a blood-filled abdominal cavity. She received a total of 10 units of packed red blood cells and 6 units of fresh frozen plasma for the resuscitation. She was discharged on the eighth postoperative day without any complications.

title: Spontaneous uterine XXXX at 15 weeks' gestation in a @entity0 with a history of cesarean delivery after removal of shirodkar cerclage.

answer: @entity2


abstract: A pregnant @entity0 presented with acute upper @entity3 and @entity1 at 15 weeks' gestation. She had a history of cesarean delivery for abruption after the removal of a Shirodkar cerclage that was placed because of cervical @entity6 caused by conization. She became pregnant again 14 months later. Ultrasonography revealed no significant findings, and a single intrauterine pregnancy with positive fetal heart activity was confirmed. An @entity5 was suspected because abdominal radiography showed multiple air-fluid levels in the colon. Over the 3 hours following admission, her symptoms gradually worsened, and plain abdominal computed tomography (CT) showed a large @entity4 in the abdominal cavity, but the uterine wall appeared intact at this time. Subsequently, dynamic CT revealed discontinuity of the uterine muscle layer. During laparotomy, uterine @entity2 with complete opening of the uterine wall at the site of the previous transverse scar was identified. A dead fetus was located within the amniotic sac in a blood-filled abdominal cavity. She received a total of 10 units of packed red blood cells and 6 units of fresh frozen plasma for the resuscitation. She was discharged on the eighth postoperative day without any complications.

title: Spontaneous uterine @entity2 at 15 weeks' gestation in a XXXX with a history of cesarean delivery after removal of shirodkar cerclage.

answer: @entity0


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity3 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity0 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity0 had been diagnosed with either @entity4 major (BTM) or @entity4 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity1 chelator-either @entity7 , @entity5 ( @entity5 in the United States), @entity6 , or a combination of @entity5 and @entity6 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity0 . In the right ears, the overall incidence of @entity3 as manifested by @entity2 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity3 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity3 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity0 with suspected @entity4 in order arrive at a prompt diagnosis and initiate timely management.

title: XXXX in @entity4 @entity0 treated with @entity1 chelation.

answer: @entity2


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity3 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity0 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity0 had been diagnosed with either @entity4 major (BTM) or @entity4 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity1 chelator-either @entity7 , @entity5 ( @entity5 in the United States), @entity6 , or a combination of @entity5 and @entity6 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity0 . In the right ears, the overall incidence of @entity3 as manifested by @entity2 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity3 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity3 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity0 with suspected @entity4 in order arrive at a prompt diagnosis and initiate timely management.

title: @entity2 in XXXX @entity0 treated with @entity1 chelation.

answer: @entity4


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity3 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity0 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity0 had been diagnosed with either @entity4 major (BTM) or @entity4 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity1 chelator-either @entity7 , @entity5 ( @entity5 in the United States), @entity6 , or a combination of @entity5 and @entity6 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity0 . In the right ears, the overall incidence of @entity3 as manifested by @entity2 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity3 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity3 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity0 with suspected @entity4 in order arrive at a prompt diagnosis and initiate timely management.

title: @entity2 in @entity4 @entity0 treated with XXXX chelation.

answer: @entity1


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity3 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity0 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity0 had been diagnosed with either @entity4 major (BTM) or @entity4 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity1 chelator-either @entity7 , @entity5 ( @entity5 in the United States), @entity6 , or a combination of @entity5 and @entity6 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity0 . In the right ears, the overall incidence of @entity3 as manifested by @entity2 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity3 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity3 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity0 with suspected @entity4 in order arrive at a prompt diagnosis and initiate timely management.

title: @entity2 in @entity4 XXXX treated with @entity1 chelation.

answer: @entity0


abstract: INTRODUCTION: @entity3 ( @entity3 ) is the second most common @entity4 in @entity0 . Current chemotherapeutic regimens include high-dose @entity5 and alkylating agents with significant variation in treatment length. The Memorial Sloan Kettering Cancer Center P6 regimen (MSKCC P6) treatment protocol is a highly aggressive regimen given over 21 weeks only. We present the outcome of @entity3 @entity0 treated in our center with this protocol over the last 15 years. PROCEDURE: We retrospectively analyzed data on the presentation, @entity0 characteristics, treatment, and outcome of all @entity3 @entity0 treated according to the MSKCC P6 regimen from 1999 to 2014. RESULTS: Of 48 @entity0 , 37 (77%) presented with a nonmetastatic disease and 26 (54%) with @entity1 located in the extremities. The 5-year overall survival (OS) of the entire cohort was 55.9%  8%. @entity2 conferred a better prognosis with a 5-year OS of 68.4%  8.5%. @entity0 with a nonmetastatic extremity @entity1 had the most favorable outcome with 5-year OS of 72.2%  9.8%. CONCLUSION: The outcome of @entity3 @entity0 after a short aggressive course of chemotherapy (the MSKCC P6 protocol), is comparable to that following other first-line treatment regimens in use, with potentially fewer long-term adverse events.

title: XXXX : A 15-Year Experience of a Single Center With the MSKCC P6 Treatment Protocol.

answer: @entity3


abstract: Induction of ischemic tolerance (IT), the ability of an organism to survive an otherwise lethal @entity2 , is the most effective known approach to preventing @entity0 . IT can be induced by exposing animals to a broad range of stimuli. In this study we tried to induce IT of brain neurons using ionizing radiation (IR). A preconditioning (pre-C) dose of 10, 20, 30 or 50 Gy of gamma rays was used 2 days before an 8 min @entity2 in adult male @entity1 . @entity2 alone caused the degeneration of almost one half of neurons in @entity3 region of hippocampus. However, a significant decrease of the number of degenerating neurons was observed after higher doses of radiation (30 and 50 Gy). Moreover, @entity2 significantly impaired the spatial memory of @entity1 as tested in Morris's water maze. In @entity1 with a 50 Gy pre-C dose, the latency times were reduced to values close to the control level. Our study is the first to reveal that IR applied in sufficient doses can induce IT and thus allow pyramidal @entity3 neurons to survive @entity2 . In addition, we show that the beneficial effect of IR pre-C is proportional to the radiation dose.

title: Ionizing radiation as preconditioning against transient cerebral ischemia in XXXX .

answer: @entity1


abstract: PURPOSE: To compare the efficacy of two different techniques for vertical bone regeneration at implant placement with particulate autogenous bone at 6 years after loading by means of a double-blind, superiority, parallel-group randomized clinical trial. MATERIALS AND METHODS: The study was conducted in a private center in Italy between April 2004 and December 2011. @entity0 in whom vertical bone augmentation was indicated in combination with the placement of single or multiple implants were eligible for inclusion in this trial. @entity0 were randomized to receive either resorbable collagen barriers supported by an osteosynthesis plate (test group) or nonresorbable @entity1 -reinforced expanded @entity2 barriers (control group). The outcome variables-radiographic bone variation at implant sites, implant failures, and complications- were evaluated 6 years after loading. Randomization was done by computer, with allocation concealed by opaque sequentially numbered sealed envelopes. The @entity0 and the radiographic examiner were blinded to group assignment. RESULTS: Twenty-two @entity0 were randomized: 11 to the resorbable barrier group and 11 to the nonresorbable (control) group. One control group @entity0 dropped out. The mean bone level 6 years after surgery was 1.33 mm for the resorbable group and 1.00 mm for the nonresorbable group. The adjusted difference in bone changes between groups was 0.15 mm (95% confidence interval, -0.39 to 0.69, P = .5713). No implant failures or complications occurred after loading. CONCLUSION: No differences were observed in this comparison of resorbable and nonresorbable barriers with simultaneous implant placement for vertical ridge augmentation.

title: Bone level variation after vertical ridge augmentation: resorbable barriers versus XXXX -reinforced barriers. A 6-year double-blind randomized clinical trial.

answer: @entity1


abstract: Balance control (the ability to maintain an upright posture) is asymmetrically controlled in a proportion of @entity0 with @entity1 . Gait asymmetries have been linked to the pathophysiology of freezing of gait. We speculate that asymmetries in balance could contribute to freezing by a) hampering the unloading of the stepping leg and/or b) leading to a preferred stance leg during gait, which then results in asymmetric gait. To investigate this, we examined the relationship between balance control and weight-bearing asymmetries and freezing. We included 20 @entity0 @entity0 with @entity2 (tested OFF medication; nine freezers) and nine healthy controls. Balance was perturbed in the sagittal plane, using continuous multi-sine perturbations, applied by a motion platform and by a force at the sacrum. Applying closed-loop system identification techniques, relating the body sway angle to the joint torques of each leg separately, determined the relative contribution of each ankle and hip joint to the total amount of joint torque. We also calculated weight-bearing asymmetries. We determined the 99-percent confidence interval of weight-bearing and balance-control asymmetry using the responses of the healthy controls. Freezers did not have larger asymmetries in weight bearing (p=0.85) nor more asymmetrical balance control compared to non-freezers (p=0.25). The healthy linear one-to-one relationship between weight bearing and balance control was significantly different for freezers and non-freezers (p=0.01). Specifically, non-freezers had a significant relationship between weight bearing and balance control (p=0.02), whereas this relation was not significant for freezers (p=0.15). Balance control is asymmetrical in most @entity0 (about 75 percent) with @entity1 , but this asymmetry is not related to freezing. The relationship between weight bearing and balance control seems to be less pronounced in freezers, compared to healthy controls and non-freezers. However, this relationship should be investigated further in larger groups of @entity0 .

title: Balance asymmetry in XXXX and its contribution to freezing of gait.

answer: @entity1


abstract: UNASSIGNED: The Jarisch-Herxheimer reaction (JHR) is a transient @entity1 triggered hours after the start of antibiotic treatment of @entity10 , namely syphilis. Clinically, JHR manifests as an abrupt onset of constitutional symptoms and exacerbation of cutaneous lesions that resolve without intervention. JHR's pathogenesis is unclear and it is histopathologically rarely reported. Herein, the authors report a 47-year-old @entity0 , with solitary @entity9 and positive Lyme disease serology, who presented for medical care 14 days after commencement of @entity7 therapy. She complained of malaise, facial @entity4 , and acquisition of additional plaques characterized by swelling, @entity8 , @entity3 , and exfoliative scale. Punch biopsies demonstrated subacute to chronic spongiotic psoriasiform reaction patterns with a superficial lymphocytic infiltrate. By Borrelia-specific immunohistochemistry, spirochetes were found in the deep dermis, unassociated with @entity1 , and focally in the upper spinous layer, associated with spongiosis. @entity6 DNA was detected by nested polymerase chain reaction. @entity7 was discontinued, and symptoms and signs resolved within a few days. Liberation of endotoxin-like materials (eg, lipoproteins) from degenerating spirochetes and concomitant cytokine production is the suspected cause of JHR and supported by the finding of lesional spirochetes. Alternatively, a reversal reaction with a @entity2 reaction is also a plausible cause based on spirochetes found in the @entity5 .

title: Delayed Onset of the Jarisch-Herxheimer Reaction in XXXX -Treated Disease: A Case Report and Review of its Histopathology and Implications for Pathogenesis.

answer: @entity7


abstract: @entity3 (NiV) causes fatal @entity1 in @entity0 . To characterize the role of the matrix (M) protein in the viral life cycle, we generated a reverse genetics system based on @entity2 . Using an enhanced green fluorescent protein (eGFP)-expressing M protein-deleted NiV, we observed a slightly increased cell-cell fusion, slow replication kinetics, and significantly reduced peak titers compared to the parental virus. While increased amounts of viral proteins were found in the supernatant of cells infected with M-deleted NiV, the infectivity-to-particle ratio was more than 100-fold reduced, and the particles were less thermostable and of more irregular morphology. Taken together, our data demonstrate that the M protein is not absolutely required for the production of cell-free NiV but is necessary for proper assembly and release of stable infectious NiV particles. IMPORTANCE: Henipaviruses cause a severe disease with high mortality in @entity0 @entity0 . Therefore, these viruses can be studied only in biosafety level 4 (BSL-4) laboratories, making it more challenging to characterize their life cycle. Here we investigated the role of the @entity3 matrix protein in virus-mediated cell-cell fusion and in the formation and release of newly produced particles. We found that even though low levels of infectious viruses are produced in the absence of the matrix protein, it is required for the release of highly infectious and stable particles. Fusogenicity of matrixless viruses was slightly enhanced, further demonstrating the critical role of this protein in different steps of @entity3 spread.

title: XXXX Matrix Protein Influences Fusogenicity and Is Essential for Particle Infectivity and Stability.

answer: @entity3


abstract: UNASSIGNED: @entity2 healing is characterized by an intense increase in modeling and remodeling of bone, which allows removal of the cast after a stable @entity2 within 3 to 5 weeks. However, at that time, bone strength has not recovered yet. We studied the changes in @entity1 ( @entity1 ), microarchitecture, and @entity1 after a @entity2 during a 2-year follow-up in comparison to the contralateral side and the association between the 2-year stiffness and baseline @entity1 , microarchitecture, and early changes in these parameters. The fractured side of 14 postmenopausal @entity0 (mean age 64        8 years) with a conservatively treated @entity2 was scanned by high-resolution peripheral quantitative computed tomography (HRpQCT) at 1 to 2, 3 to 4, 6 to 8, and 12 weeks and 2 years postfracture. The same region contralaterally was scanned as well at the 2-year visit. @entity1 , microarchitecture, and stiffness parameters were determined and the @entity2 side was compared with the contralateral side using a linear mixed-effect model. Spearman's correlation was used to correlate the 2-year @entity1 with baseline @entity1 , microarchitecture, and early 3-month changes in these parameters. Two years postfracture, cortical and trabecular thickness and torsional and bending stiffness were significantly higher at the fractured side compared with the nonfractured side (21%, 55%, 31%, and 29%, respectively, p < 0.05), whereas @entity1 was similar. Two-year torsional and bending stiffness correlated significantly with baseline @entity1 and cortical perimeter ( rho  >=  0.63, p < 0.016) but not with early changes in bone parameters. Using HRpQCT, this study illustrates that @entity2 healing is not completed by the time the cast is removed. We showed that from 6 weeks to 2 years postfracture, large changes occur in @entity1 , microarchitecture, and biomechanical parameters at the fractured side, which were fully recovered after 2 years in comparison to the nonfractured contralateral side. Interestingly, higher 2-year torsional and bending stiffness were associated with lower @entity1 and higher cortical perimeter at baseline.    2015 American Society for Bone and Mineral Research.

title: XXXX Repair in the Distal Radius in Postmenopausal @entity0 : A Follow-Up 2 Years Postfracture Using HRpQCT.

answer: @entity2


abstract: UNASSIGNED: @entity2 healing is characterized by an intense increase in modeling and remodeling of bone, which allows removal of the cast after a stable @entity2 within 3 to 5 weeks. However, at that time, bone strength has not recovered yet. We studied the changes in @entity1 ( @entity1 ), microarchitecture, and @entity1 after a @entity2 during a 2-year follow-up in comparison to the contralateral side and the association between the 2-year stiffness and baseline @entity1 , microarchitecture, and early changes in these parameters. The fractured side of 14 postmenopausal @entity0 (mean age 64        8 years) with a conservatively treated @entity2 was scanned by high-resolution peripheral quantitative computed tomography (HRpQCT) at 1 to 2, 3 to 4, 6 to 8, and 12 weeks and 2 years postfracture. The same region contralaterally was scanned as well at the 2-year visit. @entity1 , microarchitecture, and stiffness parameters were determined and the @entity2 side was compared with the contralateral side using a linear mixed-effect model. Spearman's correlation was used to correlate the 2-year @entity1 with baseline @entity1 , microarchitecture, and early 3-month changes in these parameters. Two years postfracture, cortical and trabecular thickness and torsional and bending stiffness were significantly higher at the fractured side compared with the nonfractured side (21%, 55%, 31%, and 29%, respectively, p < 0.05), whereas @entity1 was similar. Two-year torsional and bending stiffness correlated significantly with baseline @entity1 and cortical perimeter ( rho  >=  0.63, p < 0.016) but not with early changes in bone parameters. Using HRpQCT, this study illustrates that @entity2 healing is not completed by the time the cast is removed. We showed that from 6 weeks to 2 years postfracture, large changes occur in @entity1 , microarchitecture, and biomechanical parameters at the fractured side, which were fully recovered after 2 years in comparison to the nonfractured contralateral side. Interestingly, higher 2-year torsional and bending stiffness were associated with lower @entity1 and higher cortical perimeter at baseline.    2015 American Society for Bone and Mineral Research.

title: @entity2 Repair in the Distal Radius in Postmenopausal XXXX : A Follow-Up 2 Years Postfracture Using HRpQCT.

answer: @entity0


abstract: Despite the known benefits of early treatment initiation for individual morbidity and mortality, as well as for reducing the risk of transmission, late presentation (LP) to @entity2 / @entity3 services remains a major concern in many countries. There is little information on LP from middle- and low-income countries and studies that do evaluate LP commonly disaggregate data by sex. It is rare, however, for researchers to further disaggregate the data by pregnancy status so it remains unclear if pregnancy status modifies the effects associated with sex. The study was conducted at the only State Reference Center for @entity2 / @entity3 in Salvador, Brazil's third largest city. LP was defined as a @entity0 accessing services with a @entity1 < 350 cells/mm(3). Data were abstracted from the electronic medical records of 1421 @entity0 presenting between 2007 and 2009. @entity1 counts and viral load (VL) information was validated with data from the National @entity1 /VL Database. Descriptive and bivariate statistics were conducted to inform the multivariate analysis. Adjusted prevalence ratios (APR) were estimated using generalized linear models due to the high frequency of the outcome. Half of the sample (52.5%; n = 621) was classified as LP. Compared to the prevalence among pregnant @entity0 (21.1%), the prevalence of LP was more than twice as high among non-pregnant @entity0 (56.0%) and among @entity0 (55.4%). The multivariate analysis demonstrated no statistical difference between @entity0 and nonpregnant @entity0 ( @entity4 .04; 95%CI 0.92-1.19), but the APR of LP for nonpregnant @entity0 was 53% less than @entity0 (APR 0.47; 95%CI 0.33-0.68). These results highlight the importance of analyzing data disaggregated not only by sex but also by pregnancy status to accurately identify the risk factors associated with LP so that programs and policies can effectively and efficiently address LP in Brazil and beyond.

title: What's pregnancy got to do with it? Late presentation to @entity2 / XXXX services in Northeastern Brazil.

answer: @entity3


abstract: Despite the known benefits of early treatment initiation for individual morbidity and mortality, as well as for reducing the risk of transmission, late presentation (LP) to @entity2 / @entity3 services remains a major concern in many countries. There is little information on LP from middle- and low-income countries and studies that do evaluate LP commonly disaggregate data by sex. It is rare, however, for researchers to further disaggregate the data by pregnancy status so it remains unclear if pregnancy status modifies the effects associated with sex. The study was conducted at the only State Reference Center for @entity2 / @entity3 in Salvador, Brazil's third largest city. LP was defined as a @entity0 accessing services with a @entity1 < 350 cells/mm(3). Data were abstracted from the electronic medical records of 1421 @entity0 presenting between 2007 and 2009. @entity1 counts and viral load (VL) information was validated with data from the National @entity1 /VL Database. Descriptive and bivariate statistics were conducted to inform the multivariate analysis. Adjusted prevalence ratios (APR) were estimated using generalized linear models due to the high frequency of the outcome. Half of the sample (52.5%; n = 621) was classified as LP. Compared to the prevalence among pregnant @entity0 (21.1%), the prevalence of LP was more than twice as high among non-pregnant @entity0 (56.0%) and among @entity0 (55.4%). The multivariate analysis demonstrated no statistical difference between @entity0 and nonpregnant @entity0 ( @entity4 .04; 95%CI 0.92-1.19), but the APR of LP for nonpregnant @entity0 was 53% less than @entity0 (APR 0.47; 95%CI 0.33-0.68). These results highlight the importance of analyzing data disaggregated not only by sex but also by pregnancy status to accurately identify the risk factors associated with LP so that programs and policies can effectively and efficiently address LP in Brazil and beyond.

title: What's pregnancy got to do with it? Late presentation to XXXX / @entity3 services in Northeastern Brazil.

answer: @entity2


abstract: BACKGROUND: Development of de novo donor-specific antibodies (dnDSA) is associated with late or @entity1 ( @entity1 ) and poor graft outcome in low-risk kidney transplant recipients. High-level soluble @entity3 (sBAFF) was observed in kidney recipients at higher risk of developing dnDSA. METHODS: We longitudinally analyzed sBAFF levels in 81 consecutive primary pediatric kidney recipients monitored for de novo human leukocyte antigen (HLA) antibody (Ab) occurrence to gain insight into the events conditioning B-cell activation posttransplant and to analyze the usefulness of paired DSA-sBAFF monitoring in this clinical setting. RESULTS: At a median follow-up of 65 months, 23 @entity0 (28%) developed dnDSA, with 13 of 23 developing @entity1 . Irrespective of HLA Ab status, sBAFF levels progressively increased in all @entity0 in the first posttransplant year, thereafter reaching a plateau. sBAFF levels were influenced by the degree of @entity2 match and donor age. Despite higher levels of sBAFF in HLA Ab-positive @entity0 (median and 95% confidence interval sBAFF in DSA+non-DSA @entity0 : 568, 534-608 pg/mL vs. 502, 422-548 pg/mL in Ab-negative @entity0 ; P<0.05), we found that sBAFF monitoring could not predict DSA development by a time to event longitudinal analysis. Moreover, sBAFF kinetics up to @entity1 onset could not anticipate @entity1 development in the DSA cohort. CONCLUSION: Our findings provide evidence of early posttransplant B-cell activation even in unsensitized recipients of first kidney allograft. The significance of this activation, likely induced by exposition to the allograft, is yet unclear.

title: Posttransplant Soluble XXXX Kinetics in Pediatric Recipients of First Kidney Allograft.

answer: @entity3


abstract: UNASSIGNED: In the present paper, we focus on the age of onset for @entity2 in a population-based sample in the Parma, distinguishing its different subtypes and considering definite and probable diagnoses. Age of @entity0 onset is a useful clinical feature for differential diagnosis between primary @entity0 and between primary and secondary @entity0 forms. A total of 904 subjects representative of the Parma's adult general population were interviewed face to face by a physician from the Parma @entity0 Centre, using a validated questionnaire specially designed for the diagnosis of primary @entity0 according to the @entity1 . In the majority of subjects diagnosed with definite @entity2 , age of onset was 39  years or less, while mean age of onset was 29.7  years (SD 16.3  years, range 5-79  years), the median being 25  years. Both infrequent and frequent episodic definite @entity2 first occurred in the majority of cases in the second, third and fourth decades. Subjects with chronic definite @entity2 reported a later onset in life (i.e. fourth, fifth and sixth decades). In our study, mean age of onset for probable @entity2 was 23.7  years (SD 9.2  years, range 10-40  years) and the median was 22  years. In no case did we find significant gender differences. Our study results are similar to most of those reported in the literature. Further research needs to be done in the Italian epidemiological context, given the lack of literature reports on this topic.

title: XXXX in Parma's adult general population: a focus on age of onset.

answer: @entity2


abstract: A small hydrological basin (Lerma, NE Spain), transformed from its natural state (steppe) to rain-fed agriculture and recently to irrigation agriculture, has been monitored across four seasons of an agricultural year. The goal of this study was to assess how and whether agricultural activities impacted the nearby freshwater ecosystems via runoff. Specifically, we assessed the @entity0 of three @entity4 herbicides, @entity5 , @entity1 and @entity2 on the photosynthetic efficiency and structure of algal benthic biofilms (i.e., phototropic periphyton) in the small creek draining the basin. It was expected that the seasonal runoff of the herbicides in the creek affected the sensitivity of the periphyton in accord with the rationale of the Pollution Induced Community Tolerance (PICT): the exposure of the community to pollutants result in the replacement of sensitive species by more tolerant ones. In this way, PICT can serve to establish causal linkages between pollutants and the observed biological impacts. The periphyton presented significantly different sensitivities against @entity5 through the year in accord with the seasonal application of this herbicide in the crops nowadays. The sensitivity of already banned herbicides, @entity1 and @entity2 does not display a @entity3 . The different sensitivities to herbicides were in agreement with the expected exposures scenarios, according to the agricultural calendar, but not with the concentrations measured in water, which altogether indicates that the use of PICT approach may serve for long-term monitoring purposes. That will provide not only causal links between the occurrence of chemicals and their impacts on natural communities, but also information about the occurrence of chemicals that may escape from traditional sampling methods (water analysis). In addition, the EC50 and EC10 of periphyton for @entity5 or @entity2 are the first to be published and can be used for impact assessments.

title: Impacts of agricultural irrigation on nearby freshwater ecosystems: The seasonal influence of XXXX herbicides in benthic algal communities.

answer: @entity4


abstract: BACKGROUND: Hazelnut @entity3 shows distinct clinical patterns that can be predicted through component-resolved diagnosis. However, identification of sensitization profiles remains incomplete. METHODS: Sera of 75 @entity0 @entity1 to hazelnuts, 14 @entity0 with @entity2 ( @entity2 ) sensitized to hazelnuts, 15 hazelnut-tolerant individuals with specific IgE (sIgE) to hazelnuts and 15 healthy control individuals were tested for sIgE reactivity to rCor a 1.04, rCor a 8, nCor a 9, nCor a 11, rCor a 14, rBet v 1, rBet v 2 and cross-reactive @entity4 determinants (CCDs). RESULTS: Sensitization to Cor a 14 was observed in 18 out of 20 preschool @entity0 , 8 out of 10 school-aged @entity0 and 2 out of 7 adults with generalized reactions and in 3 out of 14 @entity0 with @entity2 . Only 2 out of 38 @entity0 with an @entity3 ( @entity3 ) were sensitized to Cor a 14. No sensitization to Cor a 14 was observed in the group of hazelnut-tolerant and healthy control individuals. Sensitization to Cor a 1.04 was seen in 36 out of 38 @entity3 @entity0 and in 14 out of 37 @entity0 with generalized reactions. However, only 3 @entity0 with generalized reactions were monosensitized to Cor a 1.04. Sensitization to Cor a 9 was observed in 26 out of 37 @entity0 with generalized reactions and in 4 out of 14 @entity0 with @entity2 . Sensitization to Cor a 11, Cor a 8, rBet v 2 and CCDs was rare. CONCLUSIONS: Sensitization to Cor a 14 can have early onset and shows age-related variations. Together with Cor a 9, Cor a 14 enables us to correctly identify almost 90% of @entity0 with generalized reactions to hazelnut.    2014 S. Karger AG, Basel.

title: Cor a 14: missing link in the molecular diagnosis of hazelnut XXXX ?

answer: @entity3


abstract: BACKGROUND: The aim of the present study was to assess whether @entity0 is a risk determinant for knee and @entity3 ( @entity2 ) in former professional football players and to explore @entity2 -related activity and work limitations. METHODS: To retrieve the relevant recent literature, the Medline, Embase and Sportdiscus databases were systematically searched for studies published from January 2000 to May 2012. Included studies must be primary studies that are written in English, Dutch, French or German and involve former professional football players; injury had to be studied as an independent variable; and knee/ @entity3 , work participation or limited activities had to be described as an outcome. The data from included studies were extracted using a standardised extraction form, and the methodological quality was assessed. RESULTS: No studies were retrieved about injury as a risk determinant for knee/ @entity3 in former professional football players. Four studies about @entity2 -related activity and work limitations were included (three of high and one of moderate methodological quality). Up to 17% of former professional football players with knee/ @entity3 reported suffering from @entity1 and discomfort during activities such as squatting, walking and climbing stairs. Former professional football players with knee/ @entity3 reported that their conditions were very @entity1 , chronically @entity1 and affected their daily lives, while 28% reported work-related limitations. CONCLUSION: Knee and @entity3 in former professional football players causes @entity1 and discomfort that has negative consequences for daily life and work activities. An @entity2 health examination programs should be developed to empower the sustainable health and functioning of professional football players.

title: Risk and consequences of XXXX after a professional football career: a systematic review of the recent literature.

answer: @entity2


abstract: INTRODUCTION: Accurate, continuous, left @entity1 (SV) measurements can convey large amounts of information about @entity0 hemodynamic status and response to therapy. However, direct measurements are highly invasive in clinical practice, and current procedures for estimating SV require specialized devices and significant approximation. METHOD: This study investigates the accuracy of a three element Windkessel model combined with an aortic pressure waveform to estimate SV. Aortic pressure is separated into two components capturing; 1) resistance and compliance, 2) characteristic impedance. This separation provides model-element relationships enabling SV to be estimated while requiring only one of the three element values to be known or estimated. Beat-to-beat SV estimation was performed using population-representative optimal values for each model element. This method was validated using measured SV data from porcine experiments (N=3 female Pietrain @entity2 , 29-37 kg) in which both ventricular volume and aortic pressure waveforms were measured simultaneously. RESULTS: The median difference between measured SV from left ventricle (LV) output and estimated SV was 0.6 ml with a 90% range (5th-95th percentile) -12.4 ml-14.3 ml. During periods when changes in SV were induced, cross correlations in between estimated and measured SV were above R=0.65 for all cases. CONCLUSION: The method presented demonstrates that the magnitude and trends of SV can be accurately estimated from pressure waveforms alone, without the need for identification of complex physiological metrics where strength of correlations may vary significantly from @entity0 to @entity0 .

title: Continuous XXXX volume estimation from aortic pressure using zero dimensional cardiovascular model: proof of concept study from porcine experiments.

answer: @entity1


abstract: INTRODUCTION: Currently there is little information on the effects of prolactin (PRL) on the coagulation and fibrinolytic systems. OBJECTIVE: The aim of this study was to evaluate the effects of hypeprolactinemia on the parameters of the hemostatic system and activation of the coagulation system. METHODS: We studied PRL levels, body mass index (BMI), values of activated partial thromboplastin time (aPTT), prothrombin time (PT), @entity1 time (TT), D-dimer level, @entity3 factor antigen (vWFAg) and fibrinogen in 15 young female @entity0 with @entity2 before and after therapy and in 15 healthy female controls. RESULTS: As expected, pretreatment PRL levels were significantly higher in @entity0 than in controls (140.90 +/- 42.87 vs. 12.53 +/- 4.05 ng/ml; p < 0.001). PT, although still in the normal range, was prolonged in @entity0 with @entity4 as compared to the control group (13.53 +/- 1.39 vs. 12.65 +/- 0.53 s; p = 0.03) and normalized after therapy (12.69 +/- 0.65 vs. 12.65 +/- 0.53 s; p = 0.88). TT, although in normal range, was significantly shorter in the hypeprolactinemic @entity0 than in the controls (14.34 +/- 4.52 vs. 17.21 +/- 1.35 s; p < 0.025) and after treatment remained significantly shorter than in the controls (15.17 +/- 1.55 vs. 17.21 +/- 1.35 s; p < 0.0001). D-dimer values before treatment in the @entity0 with hyperproplactinemia were above the normal range (239.47 +/- 107.93 vs. 131.27 +/- 50.64 ng/ml, p = 0.002) and decreased to normal values after therapy (239.47 +/- 107.93 vs. 146.60 +/- 39.15 ng/ml; p < 0.001). D-dimer levels correlated with PRL (r = 0.30) and the change in serum D-dimer values significantly correlated with the change in PRL levels during therapy (r = 0.62). aPTT, vWFAg and fibrinogen were similar in @entity0 and controls. CONCLUSION: In our study, increased @entity1 generation that resulted in elevated D-dimer levels may be one of the contributing factors to the prethrombotic state in @entity0 with @entity4 .

title: The influence of @entity4 on coagulation parameters in females with XXXX .

answer: @entity2


abstract: INTRODUCTION: Currently there is little information on the effects of prolactin (PRL) on the coagulation and fibrinolytic systems. OBJECTIVE: The aim of this study was to evaluate the effects of hypeprolactinemia on the parameters of the hemostatic system and activation of the coagulation system. METHODS: We studied PRL levels, body mass index (BMI), values of activated partial thromboplastin time (aPTT), prothrombin time (PT), @entity1 time (TT), D-dimer level, @entity3 factor antigen (vWFAg) and fibrinogen in 15 young female @entity0 with @entity2 before and after therapy and in 15 healthy female controls. RESULTS: As expected, pretreatment PRL levels were significantly higher in @entity0 than in controls (140.90 +/- 42.87 vs. 12.53 +/- 4.05 ng/ml; p < 0.001). PT, although still in the normal range, was prolonged in @entity0 with @entity4 as compared to the control group (13.53 +/- 1.39 vs. 12.65 +/- 0.53 s; p = 0.03) and normalized after therapy (12.69 +/- 0.65 vs. 12.65 +/- 0.53 s; p = 0.88). TT, although in normal range, was significantly shorter in the hypeprolactinemic @entity0 than in the controls (14.34 +/- 4.52 vs. 17.21 +/- 1.35 s; p < 0.025) and after treatment remained significantly shorter than in the controls (15.17 +/- 1.55 vs. 17.21 +/- 1.35 s; p < 0.0001). D-dimer values before treatment in the @entity0 with hyperproplactinemia were above the normal range (239.47 +/- 107.93 vs. 131.27 +/- 50.64 ng/ml, p = 0.002) and decreased to normal values after therapy (239.47 +/- 107.93 vs. 146.60 +/- 39.15 ng/ml; p < 0.001). D-dimer levels correlated with PRL (r = 0.30) and the change in serum D-dimer values significantly correlated with the change in PRL levels during therapy (r = 0.62). aPTT, vWFAg and fibrinogen were similar in @entity0 and controls. CONCLUSION: In our study, increased @entity1 generation that resulted in elevated D-dimer levels may be one of the contributing factors to the prethrombotic state in @entity0 with @entity4 .

title: The influence of XXXX on coagulation parameters in females with @entity2 .

answer: @entity4


abstract: OBJECTIVES: To correlate pharmacokinetic parameters of 3-T dynamic contrast-enhanced (DCE-)MRI with histopathologic microvascular and lymphatic parameters in organ-confined @entity2 . METHODS: In 18 @entity0 with unilateral peripheral zone (pT2a) @entity1 who underwent DCE-MRI prior to radical prostatectomy (RP), the following pharmacokinetic parameters were assessed: permeability surface area volume transfer constant (K (trans)), extravascular extracellular volume (Ve) and rate constant (K ep). In the RP sections blood and lymph vessels were visualised immunohistochemically and automatically examined and analysed. Parameters assessed included microvessel density (MVD), area (MVA) and perimeter ( @entity3 ) as well as lymph vessel density (LVD), area (LVA) and perimeter (LVP). RESULTS: A negative correlation was found between age and K (trans) and K ep for @entity1 (r   =   -0.60, p   =   0.009; r   =   -0.67, p   =   0.002) and normal (r   =   -0.54, p   =   0.021; r   =   -0.46, p   =   0.055) tissue. No correlation existed between absolute values of microvascular parameters from histopathology and DCE-MRI. In contrast, the ratio between @entity1 and normal tissue (correcting for individual microvascularity variations) significantly correlated between K ep and MVD (r   =   0.61, p   =   0.007) and @entity3 (r   =   0.54, p   =   0.022). The lymphovascular parameters showed only a correlation between LVA and K ep (r   =   -0.66, p   =   0.003). CONCLUSIONS: Significant correlations between DCE-MRI and histopathologic parameters were found when correcting for interpatient variations in microvascularity. KEY POINTS:     Normal prostate tissue shows strong heterogeneity in microvascularity.     @entity2 shows increased and less heterogeneous microvascularity.     Normal and @entity1 tissue shows considerable variation in microvascularity between @entity0 .     DCE-MRI should take into account the interprostatic heterogeneity of microvasculature between @entity0 .

title: Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined XXXX .

answer: @entity2


abstract: We studied the effect of @entity1 on the prevention of stone recurrence in 134 @entity0 with recurrent, idiopathic @entity2 @entity3 . They consisted of 113 male @entity0 and 21 female, between 16 and 72 years with an average age of 42.7. The @entity0 were divided into two groups according to the type of stone occurrence; those with multiple stones without previous stone episodes (multiple stone group), and the those with recurrent stones (stone episode group). Twenty three @entity0 belonged to the multiple stone group and 111 @entity0 belonged to the stone episode group. The stones in 19 of the 23 @entity0 in the multiple stone group remained stable throughout the study, while stones in 4 grew. Fifty-nine of the 111 @entity0 in the stone episode group were free from recurrence, but the others showed recurrence. Statistical analyses was done on the stone episode group. The stone recurrence rate of all of the 111 cases showed significant decrease during prophylactic treatment with @entity1 (p less than 0.01), although the observation period before treatment was 73.0 +/- 65.8 months and that during and after treatment was 28.2 +/- 12.1 months. During the two years before and after prophylaxis 79 @entity0 also showed a significantly decreased recurrence rate. Moreover, regarding 37 cases without any stones at the start of treatment, stone recurrence rate decreased significantly after the administration of @entity1 . Throughout this study, we used a new method for evaluating reasonable stone recurrence. It did not calculate the number of stones recurred, but the stone-forming circumstance in each kidney.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A study of XXXX in the prevention of recurrent calcium oxalate stones].

answer: @entity1


abstract: Physiological correlates of @entity1 , substance use onset and initiation of risky sexual behavior have not been studied in adolescents with prenatal drug exposure. We studied the concordance between baseline @entity9 ( @entity9 ) at age 3 and baseline @entity6 levels at age 11. We hypothesized that @entity0 who showed concordance between @entity9 and @entity6 would have @entity8 scores which would in turn predict age of substance use onset and first sexual intercourse. The sample included 860 @entity0 aged 16 years participating in the Maternal Lifestyle Study, a multisite longitudinal study of @entity0 with prenatal exposure to @entity7 and other substances. Structural equation modeling was used to test pathways between prenatal substance exposure, early adversity, baseline @entity9 , baseline @entity6 , @entity8 , drug use, and sexual behavior outcomes. Concordance was studied by examining separate male and female models in which there were statistically significant interactions between baseline @entity9 and @entity6 . Prenatal substance exposure was operationalized as the number of substances to which the @entity0 was exposed. An adversity score was computed based on caregiver postnatal substance use, @entity3 and @entity5 , number of caregiver changes, socioeconomic and poverty status, quality of the home environment, and @entity0 history of protective service involvement, abuse and neglect. @entity9 and @entity6 were measured during a baseline period prior to the beginning of a task. @entity8 , based on composite scores of @entity1 and @entity4 , substance use and sexual behavior were derived from questionnaires and cognitive tests administered to the @entity0 . Findings were sex specific. In females, those with discordance between @entity9 and @entity6 (high @entity9 and low @entity6 or low @entity9 and high @entity6 ) had the most @entity4 which, in turn, predicted earlier initiation of @entity2 by age 16. Among @entity0 , there also existed a significant baseline @entity9 by baseline @entity6 interaction. @entity0 with low baseline @entity9 and high baseline @entity6 had the highest levels of @entity1 . This @entity1 was in turn related to initiation of @entity2 use by age 16 and lower age of first sexual intercourse. We found sex-specific pathways to the initiation of @entity2 use and risky sexual behavior through the combined activity of parasympathetic and neuroendocrine functioning. The study of multiple physiological systems may suggest new pathways to the study of age of onset of substance use and engagement in risky sexual behavior in adolescents.

title: Physiological correlates of XXXX that relate to drug use and risky sexual behavior in adolescents with prenatal substance exposure.

answer: @entity8


abstract: BACKGROUND: Non-coding RNAs (ncRNAs) are emerging as key regulators of many cellular processes in both physiological and pathological states. Moreover, the constant discovery of new non-coding RNA species suggests that the study of their complex functions is still in its very early stages. This variegated class of RNA species encompasses the well-known microRNAs (miRNAs) and the most recently acknowledged long non-coding RNAs (lncRNAs). Interestingly, in the last couple of years, a few studies have shown that some lncRNAs can act as miRNA sponges, i.e. as competing endogenous RNAs (ceRNAs), able to reduce the amount of miRNAs available to target messenger RNAs (mRNAs). RESULTS: We propose a computational approach to explore the ability of lncRNAs to act as ceRNAs by protecting mRNAs from miRNA repression. A seed match analysis was performed to validate the underlying regression model. We built normal and @entity1 networks of miRNA-mediated sponge interactions (MMI-networks) using @entity0 expression data provided by The Cancer Genome Atlas. CONCLUSIONS: Our study highlights a marked rewiring in the ceRNA program between normal and pathological breast tissue, documented by its "on/off" switch from normal to @entity1 , and vice-versa. This mutually exclusive activation confers an interesting character to ceRNAs as potential oncosuppressive, or oncogenic, protagonists in @entity1 . At the heart of this phenomenon is the lncRNA @entity2 , as illustrated by both the width of its antagonist mRNAs in normal-MMI-network, and the relevance of the latter in @entity0 . Interestingly, @entity2 revealed a net binding preference towards the mir-200 family as the bone of contention with its rival mRNAs.

title: Computational analysis identifies a sponge interaction network between long non-coding RNAs and messenger RNAs in human XXXX .

answer: @entity0


abstract: BACKGROUND: @entity1 , such as @entity3 ( @entity3 ), are growing in incidence and prevalence, in part due to an aging population. Support provided through home care services may be useful in attaining a more efficient and higher quality care for @entity3 @entity0 . METHODS: A systematic review was performed to identify studies examining home care interventions among adult @entity3 @entity0 incorporating all outcomes. Studies examining home care services as an alternative to acute, post-acute or hospice care and those for long-term maintenance in @entity0 ' homes were included. Studies with only a home training intervention and those without an applied research component were excluded. RESULTS: Seventeen studies (10 cohort, 4 non-comparative, 2 cross-sectional, 1 randomized) examined the support provided by home care services in 15,058 @entity3 @entity0 . Fourteen studies included @entity2 ( @entity2 ), two incorporated hemodialysis (HD) and one included both @entity2 and HD @entity0 in their treatment groups. Sixteen studies focused on the dialysis phase of care in their study samples and one study included information from both the dialysis and pre-dialysis phases of care. Study settings included nine single hospital/dialysis centers and three regional/metropolitan areas and five were at the national level. Studies primarily focused on nurse assisted home care @entity0 and mostly examined @entity2 related clinical outcomes. In @entity2 studies with comparators, @entity2 risks and technique survival rates were similar across home care assisted @entity0 and comparators. The risk of mortality, however, was higher for home care assisted @entity2 @entity0 . While most studies adjusted for age and comorbidities, information about multidimensional prognostic indices that take into account physical, psychological, cognitive, functional and social factors among @entity3 @entity0 was not easily available. CONCLUSIONS: Most studies focused on nurse assisted home care @entity0 on dialysis. The majority were single site studies incorporating small @entity0 populations. There are gaps in the literature regarding the utility of providing home care to @entity3 @entity0 and the impact this has on healthcare resources.

title: XXXX and support provided by home care services: a systematic review.

answer: @entity3


abstract: Fibronectin is a large, adhesive glycoprotein, also called opsonic alpha 2 surface-binding glycoprotein. This glycoprotein which participates in all adhesions may modulate wound healing; plasma fibronectin, because it is opsonically active, may mediate reticulo-endothelial activity. Citrated plasma samples were analysed from twenty surgical @entity0 with @entity1 . The samples were obtained preoperatively and on 1st, 3rd, 7th, 14th and 28th postoperative days. Fibronectin assay was made by laser immunonephelometry. Other samples were obtained from a population of 340 healthy male and female subjects whose age ranged from 10 to 70 years, so that reference could be made to the standard mean of fibronectin related to the age of each @entity0 . In the surgical @entity0 , there was a significant decrease in fibronectin from the first to the third postoperative day. On the 7th day, there was a secondary increase of fibronectin levels which exceeded the preoperative values at the 14th and 28th days. There was no plasma dilution when the samples were collected, this being shown by protidaemia, osmolarity and haematocrit which were measured at the same time. "Septic" and "non septic" @entity0 were compared. For septic @entity0 , fibronectin levels were lower and the secondary increase occurred later than in the non septic @entity0 . @entity0 with no secondary increase did not recover and died. Fibronectin levels were compared with other classical parameters of nutritional assessment, i.e. @entity4 , prealbumin, @entity2 and urinary @entity3 indexes. These parameters were not well correlated. However, this study may indicate the usefulness of fibronectin as an indicator of nutritional status and of non specific host defence.

title: [Changes in levels of plasma fibronectin after surgery for XXXX ].

answer: @entity1


abstract: In this study, we performed a complete histologic analysis of constructs based on large diameter (   >100  m) @entity4 ( @entity6 ) microfibers obtained via dry-wet spinning and @entity0 Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding. In many synthetic polymer-based microfiber meshes, ex post processability of fiber/cell constructs for histologic analysis may face deterring difficulties, leading to an incomplete investigation of the potential of these scaffolds. Indeed, while polymeric nanofiber (fiber diameter = tens of nanometers)/cell constructs can usually be embedded in common histologic media and easily sectioned, preserving the material structure and the antigenic reactivity, histologic analysis of large polymeric microfiber/cell constructs in the literature is really scant. This affects microfiber scaffolds based on FDA-approved and widely used polymers such as @entity6 and its copolymers. Indeed, for such constructs, especially those with fiber diameter and fiber interspace much larger than cell size, standard histologic processing is usually inefficient due to @entity2 and lack of cohesion between the synthetic and the biological phases under sectioning. In this study, the microfiber/MSC constructs were embedded in acrylic resin and the staining/reaction procedures were calibrated to demonstrate the possibility of successfully employing histologic methods in tissue engineering studies even in such difficult cases. We histologically investigated the main osteogenic markers and extracellular matrix molecules, such as alkaline phosphatase, osteopontin, @entity5 , @entity1 , @entity3 , Collagen type I and the presence of amorphous, fibrillar and mineralized matrix. Biochemical tests were employed to confirm our findings. This protocol permitted efficient sectioning of the treated constructs and good penetration of the histologic reagents, thus allowing distribution and expression of almost all the tested molecules to be revealed. Our results demonstrated that it is possible to perform histologic analyses of large-diameter @entity6 -based microfiber scaffold/MSC constructs that face the failure of standard histologic procedures.

title: Processing large-diameter XXXX microfiber mesh/mesenchymal stromal cell constructs via resin embedding: an efficient histologic method.

answer: @entity4


abstract: OBJECTIVE: The aim of the study was to evaluate laser-assisted fluorescent-dye angiography (LAA) to assess perfusion in the gastric graft and to correlate perfusion with subsequent @entity2 . BACKGROUND: @entity2 are a major source of morbidity after esophagectomy with gastric pull-up (GPU). In large part, they occur as a consequence of poor perfusion in the gastric graft. METHODS: Real-time intraoperative perfusion was assessed using LAA before bringing the graft up through the mediastinum. When there was a transition from rapid and bright to slow and less robust perfusion, this site was marked with a suture. The location of the @entity1 relative to the suture was noted and the outcome of the @entity1 ascertained by retrospective record review. RESULTS: Intraoperative LAA was used to assess graft perfusion in 150 consecutive @entity0 undergoing esophagectomy with planned GPU reconstruction. An esophagogastric @entity1 was performed in 144 @entity0 . A leak was found in 24 @entity0 (16.7%) and were significantly less likely when the @entity1 was placed in an area of good perfusion compared with when the @entity1 was placed in an area of less robust perfusion by LAA (2% vs 45%, P < 0.0001). By multivariate analysis perfusion at the site of the @entity1 was the only significant factor associated with a leak. CONCLUSIONS: Intraoperative real-time assessment of perfusion with LAA correlated with the likelihood of an @entity2 and confirmed the critical relationship between good perfusion and anastomotic healing. The use of LAA may contribute to reduced anastomotic morbidity.

title: Intraoperative Assessment of Perfusion of the Gastric Graft and Correlation With XXXX After Esophagectomy.

answer: @entity2


abstract: @entity0 -controlled analgesia (PCA, intravenous self-application of narcotics) was studied during the early postoperative period. Subjects were 40 ASA I-III @entity0 recovering from elective major and minor surgery (each 20 having undergone abdominal or orthopaedic operations). @entity5 bolusses of each 8 mg were available via a hand-button whenever the @entity0 felt @entity1 relief necessary, and delivered by a microprocessor-controlled injection pump (On-Demand Analgesia Computer, ODAC). Hourly maximum dose was set to 60 mg with a pump refractory time of 1 min between valid demands. A continuous low-dose @entity5 infusion (1 mg/h) was additionally administered in order to prevent @entity4 . Duration of the PCA period was 20.3 +/- 5.9 h (mean, standard deviation). During this time, 20.0 +/- 12.7 demands per @entity0 were recorded resulting in mean @entity5 consumption of 135.6 +/- 81.4 micrograms/kg/h. Self-administration was characterized by considerable intra- and interindividual variability. There were no statistically significant differences with regard of @entity5 consumption or @entity1 relief between abdominal and orthopaedic @entity0 , nor could any be demonstrated between the sexes. Similarly, no clear differences were found after various anaesthetic techniques (neuroleptanalgesia, @entity3 or spinal anaesthesia). Over-all efficacy and @entity0 acceptance proved to be excellent. Effectiveness of PCA was judged superior by about 68% of @entity0 when compared with previously experienced conventional postoperative analgesia. Side effects ( @entity2 , emesis, sweating) occurred in about 10-18% but were usually of minor intensity. Circulatory or respiratory problems were not observed during the PCA period. @entity0 -controlled analgesia is discussed as a promising concept for the treatment of acute @entity1 and clinical @entity1 research.

title: [Postoperative on-demand analgesia with XXXX (Fortral)].

answer: @entity5


abstract: UNASSIGNED: We aimed to report environmental and blood lead level (BLL) in China, and investigate the relationship of BLL with body mass index (BMI) and @entity1 . 5558 subjects were enrolled from 16 sites in China. BLL was measured by atomic absorption spectrometry. Obesity was defined as BMI   >=    30   kg/m(2). Median (interquartile range) of BLL was 44.00    g/L (29.00-62.16) for @entity0 and 37.79    g/L (25.13-54.35) for @entity0 , about twice higher than in U.S. POPULATION: Subjects in rural and high-economic-status areas had significantly greater BLL (P   <   0.001). However, in these areas, the lead levels in drinking water, river water and @entity2 were comparable to or significantly lower than those in urban and low-economic-status areas. After adjustment for age, urbanization, economic status and metabolic factors, BLL was independently associated with BMI in @entity0 (P for trend   <   0.001), but not in @entity0 . In fully adjusted model, increased quartiles of BLL were associated with significantly increased odds ratios of @entity1 (P for trend   <   0.01) in @entity0 . In conclusion, BLLs in Chinese adults were much higher than in developed countries. There was a sex-specific association between BLL and BMI. Elevated BLL does not appear to be associated with lead levels in drinking water or @entity2 , suggesting some other exposure source.

title: Blood lead level and its association with body mass index and XXXX in China - Results from SPECT-China study.

answer: @entity1


abstract: OBJECTIVE: To evaluate the clinicopathological characteristics and the clinical outcome of @entity1 of the female reproductive tract. MATERIAL AND METHODS: @entity0 who were operated and diagnosed with synchronous @entity1 (n = 25) at the Dokuz Eylul University Department of Obstetrics and Gynecology Gynecologic Oncology Unit between 1992 and 2012 were included into this study. Recurrent, metastatic and metachronously detected @entity1 were not included. Age at diagnosis, parity menopausal status, hormone use, presenting sign or symptoms and the clinical outcomes were evaluated. RESULTS: 20 of 25 @entity0 had @entity2 . The mean age at diagnosis was 53,6 years. The most common presenting symptom was abnormal uterine @entity3 . The median follow-up duration for all @entity0 was 69 months. Overall survival for all @entity0 was 87 months and 81 months for @entity0 with @entity2 5-year survival rate was 73% for all @entity0 and 68% for @entity0 with @entity2 . CONCLUSIONS: @entity2 togetherness is the most common in synchronous gynecologic @entity1 . They occur at a younger age and have more favorable prognosis than metastatic primary gynecologic @entity1 .

title: XXXX of the female genital tract: a 20-year experience in a single center.

answer: @entity1


abstract: INTRODUCTION: @entity1 is defined as the appearance of ectopic endometrial cells outside the uterine cavity. Ectopic cells demonstrate functional similarity to eutopic cells, but structural and molecular differences are significant and manifest themselves in gene expression of the metalloproteinase genes, integrin or the @entity3 gene. @entity4 remains to be the main symptom of the disease. @entity1 may cause dysfunction of the reproductive system and lead to @entity2 . Pathogenesis of @entity2 in @entity1 is based on its influence on the hormonal, biochemical and immunological changes in the eutopic endometrium, as well as structural damages of the ovaries and the fallopian tubes. OBJECTIVES: The aim of the study was to assess the ovarian reserve in @entity0 with @entity1 . MATERIAL AND METHODS: A total of 39 @entity0 (aged 22-34 years) with different stages of endometrial changes were recruited for the study. The number of antral follicles was rated by vaginal ultrasonography and the level of FSH was measured between days 1-3 of the menstrual cycle. The stage of the disease was established after laparoscopy with the rASRM scale. RESULTS: No statistically significant correlation between the number of follicles (AFC), the level of FSH and the stage of @entity1 was found. CONCLUSIONS: Evaluation of the number of antral follicles and measurements of the FSH level do not allow to predict the ovarian reserve in @entity0 with @entity1 .

title: Ovarian reserve assessment in XXXX with different stages of pelvic endometriosis.

answer: @entity0


abstract: OBJECTIVE: To compare the clinical therapeutic effects between @entity3 and @entity4 for the treatment of mild @entity1 . METHODS: From January 2008 to December 2012, 119 @entity0 with @entity1 diagnosed as type I or II by MRI were divided into three groups. In the @entity4 (A) group, there were 38 males and 2 females, with an average age of (25.34 +/- 6.34) years old, ranging from 18 to 48 years old; 36 @entity0 had single knee injuries, 4 @entity0 had double knee injuries and 44 knees with @entity2 . In the @entity3 (B) group,there were 37 males and 2 females, with an average age of (26.98 +/- 7.20) years old, ranging from 19 to 50 years old; 33 @entity0 had single knee injuries, 6 patiens had double knees injuries and 40 knees with @entity2 . In the combination of @entity3 and @entity4 (C) group, there were 37 males and 3 females,with an average age of (26.44 +/- 6.38) years old, ranging from 18 to 47 years old; 33 @entity0 had single knee injuries, 7 @entity0 had double knees injuries and 39 knees with @entity2 . The @entity0 were treated with injection of 3 mg @entity4 alone, 30 ml (30 microg/ml) @entity3 alone, or both two drugs respectively in knee joint cavity. All the treatment methods were carried out weekly and 4 times injections were required for a treatment course. Knee joint function was evaluated by Lysholm scale and @entity2 was examined by MRI before and after treatment. RESULTS: The scale of knee joint function was 35.68 +/- 4.15 and 65.55 +/- 7.66 in group A, 36.35 +/- 6.83 and 74.39 +/- 8.47 in group B, 36.62 +/- 6.03 and 95.47 +/- 4.78 in group C before and after treatment. Compared with that before treatment, the total scale of knee joint function improved after treatment in every group. The total scale of group C was better than that of the other groups after the treatment,but there was no significant difference between group A and group B. The effective rate of these @entity2 was 68.18% in group A, 62.5% in group B and 87.18% in group C. The effect of co-injection on @entity2 in group C was significantly better than that of @entity4 or @entity3 alone, but the difference between group A and group B was not significant. CONCLUSION: @entity3 and @entity4 are effective in the treatment of mild @entity1 , which can relieve symptoms and promote the recovery of joint function. Campared with the single injection, the combination of @entity3 and @entity4 is better.

title: [Case-control study on therapeutic effects of @entity3 and XXXX on the treatment of @entity1 ].

answer: @entity4


abstract: OBJECTIVE: To compare the clinical therapeutic effects between @entity3 and @entity4 for the treatment of mild @entity1 . METHODS: From January 2008 to December 2012, 119 @entity0 with @entity1 diagnosed as type I or II by MRI were divided into three groups. In the @entity4 (A) group, there were 38 males and 2 females, with an average age of (25.34 +/- 6.34) years old, ranging from 18 to 48 years old; 36 @entity0 had single knee injuries, 4 @entity0 had double knee injuries and 44 knees with @entity2 . In the @entity3 (B) group,there were 37 males and 2 females, with an average age of (26.98 +/- 7.20) years old, ranging from 19 to 50 years old; 33 @entity0 had single knee injuries, 6 patiens had double knees injuries and 40 knees with @entity2 . In the combination of @entity3 and @entity4 (C) group, there were 37 males and 3 females,with an average age of (26.44 +/- 6.38) years old, ranging from 18 to 47 years old; 33 @entity0 had single knee injuries, 7 @entity0 had double knees injuries and 39 knees with @entity2 . The @entity0 were treated with injection of 3 mg @entity4 alone, 30 ml (30 microg/ml) @entity3 alone, or both two drugs respectively in knee joint cavity. All the treatment methods were carried out weekly and 4 times injections were required for a treatment course. Knee joint function was evaluated by Lysholm scale and @entity2 was examined by MRI before and after treatment. RESULTS: The scale of knee joint function was 35.68 +/- 4.15 and 65.55 +/- 7.66 in group A, 36.35 +/- 6.83 and 74.39 +/- 8.47 in group B, 36.62 +/- 6.03 and 95.47 +/- 4.78 in group C before and after treatment. Compared with that before treatment, the total scale of knee joint function improved after treatment in every group. The total scale of group C was better than that of the other groups after the treatment,but there was no significant difference between group A and group B. The effective rate of these @entity2 was 68.18% in group A, 62.5% in group B and 87.18% in group C. The effect of co-injection on @entity2 in group C was significantly better than that of @entity4 or @entity3 alone, but the difference between group A and group B was not significant. CONCLUSION: @entity3 and @entity4 are effective in the treatment of mild @entity1 , which can relieve symptoms and promote the recovery of joint function. Campared with the single injection, the combination of @entity3 and @entity4 is better.

title: [Case-control study on therapeutic effects of @entity3 and @entity4 on the treatment of XXXX ].

answer: @entity1


abstract: OBJECTIVE: To compare the clinical therapeutic effects between @entity3 and @entity4 for the treatment of mild @entity1 . METHODS: From January 2008 to December 2012, 119 @entity0 with @entity1 diagnosed as type I or II by MRI were divided into three groups. In the @entity4 (A) group, there were 38 males and 2 females, with an average age of (25.34 +/- 6.34) years old, ranging from 18 to 48 years old; 36 @entity0 had single knee injuries, 4 @entity0 had double knee injuries and 44 knees with @entity2 . In the @entity3 (B) group,there were 37 males and 2 females, with an average age of (26.98 +/- 7.20) years old, ranging from 19 to 50 years old; 33 @entity0 had single knee injuries, 6 patiens had double knees injuries and 40 knees with @entity2 . In the combination of @entity3 and @entity4 (C) group, there were 37 males and 3 females,with an average age of (26.44 +/- 6.38) years old, ranging from 18 to 47 years old; 33 @entity0 had single knee injuries, 7 @entity0 had double knees injuries and 39 knees with @entity2 . The @entity0 were treated with injection of 3 mg @entity4 alone, 30 ml (30 microg/ml) @entity3 alone, or both two drugs respectively in knee joint cavity. All the treatment methods were carried out weekly and 4 times injections were required for a treatment course. Knee joint function was evaluated by Lysholm scale and @entity2 was examined by MRI before and after treatment. RESULTS: The scale of knee joint function was 35.68 +/- 4.15 and 65.55 +/- 7.66 in group A, 36.35 +/- 6.83 and 74.39 +/- 8.47 in group B, 36.62 +/- 6.03 and 95.47 +/- 4.78 in group C before and after treatment. Compared with that before treatment, the total scale of knee joint function improved after treatment in every group. The total scale of group C was better than that of the other groups after the treatment,but there was no significant difference between group A and group B. The effective rate of these @entity2 was 68.18% in group A, 62.5% in group B and 87.18% in group C. The effect of co-injection on @entity2 in group C was significantly better than that of @entity4 or @entity3 alone, but the difference between group A and group B was not significant. CONCLUSION: @entity3 and @entity4 are effective in the treatment of mild @entity1 , which can relieve symptoms and promote the recovery of joint function. Campared with the single injection, the combination of @entity3 and @entity4 is better.

title: [Case-control study on therapeutic effects of XXXX and @entity4 on the treatment of @entity1 ].

answer: @entity3


abstract: PURPOSE: A biomarker for dietary @entity2 intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of @entity1 from these sources for the prevention of @entity0 . Urinary @entity3 (HA)-a major metabolite of @entity1 -is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV. METHODS: Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9-16  years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (n  =  192) and confirmation (n  =  95) of results. RESULTS: Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (r unadjusted  =  0.47, P  <  0.0001). Yet, 79  % of the subjects were classified into same/adjacent quartiles, and only 5  % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (r unadjusted  =  0.64; 88  % in same/adjacent vs. 4  % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples. CONCLUSIONS: BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.

title: Relative validation of 24-h urinary @entity3 excretion as a biomarker for dietary XXXX intake from fruit and vegetables in healthy adolescents.

answer: @entity2