abstract: A laboratory system of examination of illicit @entity3 exhibits is described. Separation and identification of many of the components in exhibits are achieved by the use of capillary column gas chromatography and a Finnigan ion trap detector. Further examination and quantitation of the components of exhibits is achieved using two high performance liquid chromatographic (HPLC) systems. Both of these systems use identical reverse phase C8 columns. System 1 employs a solvent composed of 40% @entity2 , 10% @entity4 and 50% 0.1% v/v aqueous @entity0 . The eluant is monitored at 280 nm. This system is preferred for routine quantitative analysis of @entity3 and related alkaloids in exhibits. System 2 employs a solvent composed of 30% @entity2 and 70% 0.05M @entity1 buffer (pH = 5.0). The eluant from this system is monitored at both 220 and 280 nm. This system offers advantages in sensitivity. The relative retention times of a number of relevant substances as determined with gas chromatography and the two HPLC systems are given. The utility of the methodology for the identification and comparison of exhibits is demonstrated.

title: The examination of illicit XXXX .

answer: @entity3


abstract: The extent of the intra- and infrapyramidal mossy fiber projection (IIP-MF) in the hippocampus of @entity0 and @entity1 is strain-specific, and correlates negatively with the strain-specific capacity of avoidance learning. If variations of the IIP-MF influence the capacity for 2-way avoidance learning, then developmental modification of the IIP-MF projection in an individual member of a strain should remain correlated with its adult behavior. Pups of strains with high avoidance capacity and small IIP-MF projections (RHA @entity1 , @entity5 /2 and BALB/c @entity0 ) were injected with varying doses of @entity4 during the postnatal period. This transient @entity3 resulted in a strong, yet largely unpredictable, variability of the IIP-MF projection in the adult animals. Furthermore, postnatal saline injections also increased the variability of the IIP-MF projection; however, this was to a lesser degree than when using @entity4 . The animals were tested for 2-way avoidance learning at the age of 90-120 d. Many showed strain-atypical avoidance scores. These deviations from the inherited level of 2-way avoidance learning were strongly correlated with the magnitude of the IIP-MF projection, regardless of whether the structural changes resulted from @entity4 or saline injections. A multivariate analysis showed that the observed correlations could neither be explained by @entity4 -induced changes in brain weight nor by individual differences of other terminal fields in the hippocampal region @entity2 . These results suggest that the extent of the IIP-MF projection is influenced by several genetic and epigenetic factors. Irrespective of the underlying causes, the magnitude of the IIP-MF (or of an unknown but well-correlated variable) appears to bias the adult capacity for 2-way avoidance learning predictably.

title: Infrapyramidal mossy fibers and two-way avoidance learning: developmental modification of hippocampal circuitry and adult behavior of XXXX and @entity0 .

answer: @entity1


abstract: The extent of the intra- and infrapyramidal mossy fiber projection (IIP-MF) in the hippocampus of @entity0 and @entity1 is strain-specific, and correlates negatively with the strain-specific capacity of avoidance learning. If variations of the IIP-MF influence the capacity for 2-way avoidance learning, then developmental modification of the IIP-MF projection in an individual member of a strain should remain correlated with its adult behavior. Pups of strains with high avoidance capacity and small IIP-MF projections (RHA @entity1 , @entity5 /2 and BALB/c @entity0 ) were injected with varying doses of @entity4 during the postnatal period. This transient @entity3 resulted in a strong, yet largely unpredictable, variability of the IIP-MF projection in the adult animals. Furthermore, postnatal saline injections also increased the variability of the IIP-MF projection; however, this was to a lesser degree than when using @entity4 . The animals were tested for 2-way avoidance learning at the age of 90-120 d. Many showed strain-atypical avoidance scores. These deviations from the inherited level of 2-way avoidance learning were strongly correlated with the magnitude of the IIP-MF projection, regardless of whether the structural changes resulted from @entity4 or saline injections. A multivariate analysis showed that the observed correlations could neither be explained by @entity4 -induced changes in brain weight nor by individual differences of other terminal fields in the hippocampal region @entity2 . These results suggest that the extent of the IIP-MF projection is influenced by several genetic and epigenetic factors. Irrespective of the underlying causes, the magnitude of the IIP-MF (or of an unknown but well-correlated variable) appears to bias the adult capacity for 2-way avoidance learning predictably.

title: Infrapyramidal mossy fibers and two-way avoidance learning: developmental modification of hippocampal circuitry and adult behavior of @entity1 and XXXX .

answer: @entity0


abstract: We describe the clinical courses of four @entity0 with @entity2 ( @entity2 ). This entity is a mesenchymal disorder of early infancy characterized by the formation of @entity1 in skin, muscle, viscera, bone, and subcutaneous tissues. Previously known as @entity2 , @entity2 was formerly thought to be a rare condition that was frequently fatal. The majority of the 170 affected @entity0 we describe have been diagnosed since 1980. Furthermore, the mortality rate for these @entity0 is less than 15%. Our review includes the clinical manifestations, as well as histopathologic features, and discusses the prognosis in affected @entity0 . We found that @entity0 with solitary lesions or multiple lesions without visceral involvement generally have a benign course. However, in @entity0 with the multicentric form of the disorder and visceral involvement, 73% have died. Because the lesions may not be easily discernible and most spontaneously resolve, the condition is underdiagnosed and underreported. @entity2 is the most common @entity1 of infancy and must be considered when evaluating @entity0 who present with either @entity1 , particularly during the neonatal period.

title: XXXX : the most common @entity1 of infancy.

answer: @entity2


abstract: We describe the clinical courses of four @entity0 with @entity2 ( @entity2 ). This entity is a mesenchymal disorder of early infancy characterized by the formation of @entity1 in skin, muscle, viscera, bone, and subcutaneous tissues. Previously known as @entity2 , @entity2 was formerly thought to be a rare condition that was frequently fatal. The majority of the 170 affected @entity0 we describe have been diagnosed since 1980. Furthermore, the mortality rate for these @entity0 is less than 15%. Our review includes the clinical manifestations, as well as histopathologic features, and discusses the prognosis in affected @entity0 . We found that @entity0 with solitary lesions or multiple lesions without visceral involvement generally have a benign course. However, in @entity0 with the multicentric form of the disorder and visceral involvement, 73% have died. Because the lesions may not be easily discernible and most spontaneously resolve, the condition is underdiagnosed and underreported. @entity2 is the most common @entity1 of infancy and must be considered when evaluating @entity0 who present with either @entity1 , particularly during the neonatal period.

title: @entity2 : the most common XXXX of infancy.

answer: @entity1


abstract: OBJECTIVES: To evaluate the efficacy of treatment protocols in @entity0 overweight/ @entity1 , pertaining to outpatient of dietary preventive of SIAN (in English: @entity3 ) RMA. MATERIALS AND METHODS: We extracted data from the medical records of @entity0 with BMI>= 25 (2009-2012). It was conducted a descriptive analysis, univariate analysis (chi-square test; p <=0.05) and multivariate logistic regression analysis considering as " @entity2 " the outcome measure. RESULTS: There were 762 records (76.2% female; mean age 52 years). BMI average of beginning treatment: 30.26; BMI of the end of treatment: 28.37; minimum maximum range of variation of weight after treatment: -28.9 Kg and +6.5 Kg. The 55.2% of the sample has lost up to 4.9 kg, 32.4% from 5.0 to 9.9 kg, 8.1% from 10.0 to 19.9 Kg, 0.9% from 20 to 28.9 Kg. The higher initial BMI and the longer treatment, have a lower likelihood of @entity2 (B=-1.267, p<0.001; B =-0.408, p<0.001); females and those who have an older age are more likely to lose weight (B=0.030, p<0.003; B=1.260, p<0.001). CONCLUSIONS: The current study highlight the efficacy of treatment protocols in overweight/ @entity1 @entity0 . The population that benefits from the treatment more rigidly set on the estimated caloric needs is the one that starts from lower BMI and who therefore need less time to reach a certain @entity2 . Instead, those who started from higher BMI is a population supposedly "binger", more resistant to the single dietary treatment and, as recognized by the scientific community, it requires a multidisciplinary approach.

title: [Effectiveness of a protocol treatment for overweight/ XXXX @entity0 (SIAN - ASL RMA)].

answer: @entity1


abstract: OBJECTIVES: To evaluate the efficacy of treatment protocols in @entity0 overweight/ @entity1 , pertaining to outpatient of dietary preventive of SIAN (in English: @entity3 ) RMA. MATERIALS AND METHODS: We extracted data from the medical records of @entity0 with BMI>= 25 (2009-2012). It was conducted a descriptive analysis, univariate analysis (chi-square test; p <=0.05) and multivariate logistic regression analysis considering as " @entity2 " the outcome measure. RESULTS: There were 762 records (76.2% female; mean age 52 years). BMI average of beginning treatment: 30.26; BMI of the end of treatment: 28.37; minimum maximum range of variation of weight after treatment: -28.9 Kg and +6.5 Kg. The 55.2% of the sample has lost up to 4.9 kg, 32.4% from 5.0 to 9.9 kg, 8.1% from 10.0 to 19.9 Kg, 0.9% from 20 to 28.9 Kg. The higher initial BMI and the longer treatment, have a lower likelihood of @entity2 (B=-1.267, p<0.001; B =-0.408, p<0.001); females and those who have an older age are more likely to lose weight (B=0.030, p<0.003; B=1.260, p<0.001). CONCLUSIONS: The current study highlight the efficacy of treatment protocols in overweight/ @entity1 @entity0 . The population that benefits from the treatment more rigidly set on the estimated caloric needs is the one that starts from lower BMI and who therefore need less time to reach a certain @entity2 . Instead, those who started from higher BMI is a population supposedly "binger", more resistant to the single dietary treatment and, as recognized by the scientific community, it requires a multidisciplinary approach.

title: [Effectiveness of a protocol treatment for overweight/ @entity1 XXXX (SIAN - ASL RMA)].

answer: @entity0


abstract: BACKGROUND: Secondary endoscopic third ventriculostomy (ETV) for the management of shunt failure may be efficacious, though it may be followed by more frequent complications (including @entity2 , e.g. @entity7 ) compared to primary ETV. These complications are usually underreported in the literature. AIM: We report a case of secondary @entity7 after ETV for the management of shunt failure in a young @entity0 with @entity5 associated with @entity11 . METHODS: A 25-year-old @entity0 affected by @entity5 and @entity11 was admitted for secondary ETV for the management of shunt failure. The endoscopic procedure was preferred over shunt revision based on good results of secondary ETV, especially in @entity0 with @entity5 associated with @entity6 and @entity8 . RESULTS: Despite the surgery being uneventful, the @entity0 had early (postoperative @entity3 ) and late (secondary @entity7 ) complications. In the early postoperative period, she received external ventricular drainage followed by VP shunt reimplantation 2 weeks later. There was no @entity1 , but 1 month after the ETV she reported secondary @entity7 and @entity4 . Laboratory investigations ruled out @entity9 , which had been treated with @entity10 administration with no efficacy since the @entity0 was still without regular periods 1 year later. CONCLUSION: ETV may be followed by endocrinological complications like @entity7 that are rarely reported.

title: XXXX after Endoscopic Third Ventriculostomy for a Failed Shunt in Spina Bifida: Case Report and Review of the Literature.

answer: @entity7


abstract: PURPOSE: To investigate the effects of the @entity2 ( @entity2 )-related ocular magnification on the thickness of the macular ganglion cell complex (mGCC), and the diagnostic accuracy of the built-in normative database of the spectral-domain optical coherence tomographic (SD-OCT) instrument for @entity0 detection. METHODS: This retrospective study included 41 eyes with early primary @entity1 and 36 normal eyes. The mGCC thickness within a 20-degree circle, equivalent to a 6 mm diameter in the Gullstrand model eye, was measured in the SD-OCT images. The magnification effect was corrected using Bennett formula, and the mGCC thickness within the actual 6 mm diameter circle was determined. RESULTS: In normal eyes, the inferior corrected mGCC was significantly correlated with the @entity2 (b=-0.40, P=0.028), but correction for the magnification reduced the correlation. In 38 nonhighly myopic eyes, the sensitivity and specificity of the SD-OCT's significance maps for distinguishing @entity0 were 95.0% and 94.4% when using either the uncorrected or the corrected mGCC. In 39 highly myopic eyes, the diagnostic accuracy was lower when using the uncorrected mGCC thickness (sensitivity was 95.2% and specificity was 44.4%), and was not improved when using the corrected mGCC (81.0% and 61.1%, respectively). CONCLUSIONS: The inferior mGCC was thinner in eyes with longer @entity2 . The accuracy of the diagnosis with the SD-OCT built-in normative database for @entity0 was not improved significantly by the correction of the @entity2 -associated magnification in highly myopic eyes. Evaluation of highly myopic eyes with the nonhighly myopic normative database can lead to misdiagnosis.

title: Effect of Axial Length on Macular Ganglion Cell Complex Thickness and on XXXX Diagnosis by Spectral-Domain Optical Coherence Tomography.

answer: @entity0


abstract: Circulating biomarkers are important surrogates for monitoring disease activity in type I @entity2 (GD1). We and others have reported low high-density lipoprotein (HDL) in GD1. We assessed HDL @entity1 as a biomarker of GD1, with respect to its correlation with indicators of disease severity and its response to imiglucerase enzyme replacement therapy (ERT). In 278 consecutively evaluated GD1 @entity0 , we correlated HDL @entity1 , chitotriosidase, and @entity3 ( @entity3 ) with indicators of disease severity. Additionally, we measured the response of these biomarkers to ERT. HDL @entity1 was negatively correlated with spleen volume, liver volume, and GD severity score index; the magnitude of this association of disease severity with HDL @entity1 was similar to that for @entity3 and for chitotriosidase. Within individual @entity0 monitored over many years, there was a strikingly strong correlation of HDL with liver and spleen volumes; there was a similarly strong correlation of chitotriosidase and @entity3 with disease severity in individual @entity0 monitored serially over many years (chitotriosidase r = 0.96 to 0.98, @entity3 r = 0.88 to 0.94, and HDL r =   -0.84 to -0.94, p < 0.001). ERT for 3 years resulted in a striking increase of HDL while serum levels of chitotriosidase and @entity3 decreased. Our results reveal markedly low HDL @entity1 in untreated GD1, a correlation with indicators of disease severity in GD1, and a rise towards normal after ERT. These findings suggest HDL @entity1 merits inclusion within the "biomarker basket" for monitoring of @entity0 with GD1.

title: Evaluation of high density lipoprotein as a circulating biomarker of XXXX activity.

answer: @entity2


abstract: UNASSIGNED: The mechanism(s) mediating @entity8 may be similar to those @entity2 have been observed in plaque. We tested the hypothesis that osteoclast-like cells (OLCs) also exist in @entity8 arteries. In 205 tissue blocks obtained from 21 @entity0 undergoing carotid endarterectomy, we performed histopathologic analysis, histochemical staining for @entity13 -resistant acid phosphatase (TRAP), and immunohistochemical analysis for osteoclast and macrophage antigens, including @entity5 , @entity14 ( @entity14 ), @entity12 ( @entity12 ), receptor activator of nuclear factor-kB (RANK), and @entity10 ( @entity10 ). Lesions were classified according to the AHA system, and further grouped as calcified or non-calcified (with @entity1 cores or suture @entity9 ). Multinucleated giant cells morphologically similar to osteoclasts were frequently seen, sometimes exhibited morphologic evidence of polarization, were closely associated with regions of @entity7 , @entity3 , or granulomatous tissue, and also appeared to be associated with @entity11 and regions of intraplaque @entity6 . TRAP-positive cells often expressed the osteoclast-associated antigens @entity12 , RANK, and @entity10 . Calcification typically occurred at the base of plaque or in @entity1 cores in various morphologies, including a fine powdery pattern, a diffuse pattern of larger deposits near @entity4 clefts and @entity1 centers, and nodular forms. Regions of frank ossification were rarely observed. CONCLUSION: OLCs are frequently found in plaque, and co-localize with sub-regions of @entity4 deposition, mineralization, and @entity1 and foreign debris. True bone tissue is rare in carotid plaque, although more common in other arteries. Our findings suggest that arterial OLCs might degrade mineral deposits, prevent formation of @entity7 or both and therefore counterbalance the activity of the osteoblast-like cells in @entity8 .

title: Multinucleated giant cells in XXXX plaques of @entity0 carotid arteries: Identification of osteoclast-like cells and their specific proteins in artery wall.

answer: @entity8


abstract: UNASSIGNED: The mechanism(s) mediating @entity8 may be similar to those @entity2 have been observed in plaque. We tested the hypothesis that osteoclast-like cells (OLCs) also exist in @entity8 arteries. In 205 tissue blocks obtained from 21 @entity0 undergoing carotid endarterectomy, we performed histopathologic analysis, histochemical staining for @entity13 -resistant acid phosphatase (TRAP), and immunohistochemical analysis for osteoclast and macrophage antigens, including @entity5 , @entity14 ( @entity14 ), @entity12 ( @entity12 ), receptor activator of nuclear factor-kB (RANK), and @entity10 ( @entity10 ). Lesions were classified according to the AHA system, and further grouped as calcified or non-calcified (with @entity1 cores or suture @entity9 ). Multinucleated giant cells morphologically similar to osteoclasts were frequently seen, sometimes exhibited morphologic evidence of polarization, were closely associated with regions of @entity7 , @entity3 , or granulomatous tissue, and also appeared to be associated with @entity11 and regions of intraplaque @entity6 . TRAP-positive cells often expressed the osteoclast-associated antigens @entity12 , RANK, and @entity10 . Calcification typically occurred at the base of plaque or in @entity1 cores in various morphologies, including a fine powdery pattern, a diffuse pattern of larger deposits near @entity4 clefts and @entity1 centers, and nodular forms. Regions of frank ossification were rarely observed. CONCLUSION: OLCs are frequently found in plaque, and co-localize with sub-regions of @entity4 deposition, mineralization, and @entity1 and foreign debris. True bone tissue is rare in carotid plaque, although more common in other arteries. Our findings suggest that arterial OLCs might degrade mineral deposits, prevent formation of @entity7 or both and therefore counterbalance the activity of the osteoblast-like cells in @entity8 .

title: Multinucleated giant cells in @entity8 plaques of XXXX carotid arteries: Identification of osteoclast-like cells and their specific proteins in artery wall.

answer: @entity0


abstract: The chloroplast genome of the highly neutral-lipid-producing marine pennate diatom @entity2 was fully sequenced using high-throughput pyrosequencing. The general features and gene content were compared with three other complete diatom chloroplast genomes. The chloroplast genome is 134,918 bp with an inverted repeat of 13,330 bp and is slightly larger than the other diatom chloroplast genomes due to several low gene-density regions lacking similarity to the other diatom chloroplast genomes. Protein-coding genes were nearly identical to those from @entity1 . On the other hand, we found unique sequence variations in genes of photosystem II which differ from the consensus in other diatom chloroplasts. Furthermore, five functional unknown ORFs and a putative @entity0 recombinase gene, @entity3 , are located in the low gene-density regions. @entity3 was also identified in the plasmids of another pennate diatom, Cylindrotheca fusiformis, and in the plastid genome of the diatom endosymbiont of @entity4 . Exogenous plasmids might have been incorporated into the chloroplast genome of @entity2 sp. by lateral gene transfer. Chloroplast genome sequencing analysis of this novel diatom provides many important insights into diatom evolution.

title: High-throughput pyrosequencing of the chloroplast genome of a highly neutral-lipid-producing marine pennate diatom, XXXX .

answer: @entity2


abstract: OBJECTIVE: To calculate the rates of @entity4 detected during and after benign gynecologic surgery. To explore the role of routine intraoperative cystoscopy and determine if it helps in reducing injuries detected postoperatively. DATA SOURCES: We conducted a literature search for urinary tract injuries at benign gynecologic surgery in PubMed, EMBASE, ClinicalTrials.gov, and Web of Science from January 2004 to August 2014. We combined our results with a database from a previously published systematic review to include earlier studies. METHODS OF STUDY SELECTION: A total of 79 studies met our inclusion criteria. Excluded were letters to the editor, studies involving only selective cystoscopy in higher risk @entity0 , case reports, and reports that included injuries resulting from obstetric or oncologic procedures. TABULATION, INTEGRATION, AND RESULTS: Data from each report were classified according to type of surgery into vaginal hysterectomy, abdominal hysterectomy, laparoscopic hysterectomy, other (nonrobotic) gynecologic and urogynecologic surgery, robotic hysterectomy, and other robotic gynecologic and urogynecologic surgery. We determined the ureteric and @entity2 rates for each surgery type from studies in which routine intraoperative cystoscopy was performed and separately from studies in which it was not performed. Intraoperatively detected rates of ureteric and @entity2 were markedly higher with routine intraoperative cystoscopy. We obtained an adjusted @entity3 rate of 0.3% and a @entity2 rate of 0.8%. The estimated postoperative @entity3 detection rates @entity1 ,000 surgeries were 1.6 without routine cystoscopy and 0.7 with routine cystoscopy. @entity2 injury detection rates @entity1 ,000 surgeries were 0.8 without routine cystoscopy and 1.0 with routine cystoscopy. CONCLUSION: Although routine cystoscopy clearly increases the intraoperative detection rate of urinary tract injuries, this systematic review of 79 mostly retrospective studies shows that it does not appear to have much effect on the postoperative injury detection rate.

title: XXXX at Benign Gynecologic Surgery and the Role of Cystoscopy: A Systematic Review and Meta-analysis.

answer: @entity4


abstract: Stringent complete remission (CR) in @entity6 ( @entity6 ) requires the absence of both morphologic and flow cytometric evidence of disease. We have previously shown that persistent @entity6 detected by flow cytometry (FC+) before @entity1 ( @entity1 ) allogeneic hematopoietic cell transplantation (alloHCT) was associated with significantly increased relapse, shorter disease-free survival (DFS), and poorer @entity4 ( @entity4 ), independent of morphologic blast count. We evaluated the effect of FC status on outcomes of alloHCT for @entity6 after either @entity3 ( @entity3 ) or @entity1 regimens in 203 @entity0 ( @entity3 , n  =  80, and @entity1 , n  =  123) with no morphologic evidence of persistent @entity6 pretransplant on marrow biopsy. The allografts included 130 umbilical cord blood (UCB) and 73 sibling donors. We performed central review of pretransplant standard sensitivity FC to identify detectable FC+. Twenty-five @entity0 were FC+, including 15 (18.7%) receiving @entity3 and 10 (8.1%) @entity1 alloHCT. Among @entity1 @entity0 FC+ was associated with significantly inferior relapse, DFS, and @entity4 (multiple regression HR, 3.8; 95% CI, 1.7 to 8.7; P  <  .01 for relapse; HR, 2.9; 95% CI, 1.4 to 5.9; P  <  .01 for DFS; and HR, 3.4; 95% CI, 1.7 to 7; P  <  .01 for @entity4 ). In contrast, FC+ status was not associated with relapse or @entity2 after @entity3 . These data suggest that @entity3 , but not @entity1 , overcomes the negative effect of pretransplant FC+ after sibling or UCB alloHCT. Therefore, a @entity5 -free state is preferred for those treated with @entity1 .

title: Myeloablative, but not Reduced-Intensity, Conditioning Overcomes the Negative Effect of Flow-Cytometric Evidence of XXXX in @entity6 .

answer: @entity5


abstract: Stringent complete remission (CR) in @entity6 ( @entity6 ) requires the absence of both morphologic and flow cytometric evidence of disease. We have previously shown that persistent @entity6 detected by flow cytometry (FC+) before @entity1 ( @entity1 ) allogeneic hematopoietic cell transplantation (alloHCT) was associated with significantly increased relapse, shorter disease-free survival (DFS), and poorer @entity4 ( @entity4 ), independent of morphologic blast count. We evaluated the effect of FC status on outcomes of alloHCT for @entity6 after either @entity3 ( @entity3 ) or @entity1 regimens in 203 @entity0 ( @entity3 , n  =  80, and @entity1 , n  =  123) with no morphologic evidence of persistent @entity6 pretransplant on marrow biopsy. The allografts included 130 umbilical cord blood (UCB) and 73 sibling donors. We performed central review of pretransplant standard sensitivity FC to identify detectable FC+. Twenty-five @entity0 were FC+, including 15 (18.7%) receiving @entity3 and 10 (8.1%) @entity1 alloHCT. Among @entity1 @entity0 FC+ was associated with significantly inferior relapse, DFS, and @entity4 (multiple regression HR, 3.8; 95% CI, 1.7 to 8.7; P  <  .01 for relapse; HR, 2.9; 95% CI, 1.4 to 5.9; P  <  .01 for DFS; and HR, 3.4; 95% CI, 1.7 to 7; P  <  .01 for @entity4 ). In contrast, FC+ status was not associated with relapse or @entity2 after @entity3 . These data suggest that @entity3 , but not @entity1 , overcomes the negative effect of pretransplant FC+ after sibling or UCB alloHCT. Therefore, a @entity5 -free state is preferred for those treated with @entity1 .

title: Myeloablative, but not Reduced-Intensity, Conditioning Overcomes the Negative Effect of Flow-Cytometric Evidence of @entity5 in XXXX .

answer: @entity6


abstract: The activities of @entity4 , @entity2 , @entity5 , @entity7 and @entity3 alone and in combination against 130 isolates of @entity0 , group B streptococci and @entity8 from @entity1 were assessed by using agar dilution, checkerboard and time-kill techniques. @entity7 and @entity3 were highly active against @entity0 and group B streptococci (MIC90 0.05-0.1 mg/1) but not active against List. monocytogenes. @entity4 was more active than @entity2 and @entity5 against group B streptococci (MIC90 0.1, 0.12 and 0.24 mg/l respectively) and @entity2 was the most active against List. monocytogenes (MIC90 0.6 mg/l). Every double @entity6 combination was synergistic for 3-14% of @entity0 , 8-26% of group B streptococci and 67-100% of List. monocytogenes in the checkerboard titration. The @entity3 combinations were less synergistic than the @entity7 combinations. In time-kill evaluations using concentrations representative for cerebrospinal fluid, the killing kinetics of @entity0 were not influenced by any combination. A significant delay in killing of group B streptococci was observed with @entity4 - @entity9 and @entity2 - @entity9 combinations. A significant increased killing of List. monocytogenes was observed with @entity4 - @entity9 combinations. The other combinations did not alter the killing kinetics of group B streptococci and List. monocytogenes.

title: Activity of @entity7 and XXXX alone and in combination with penicillin, @entity2 and @entity5 against @entity1 pathogens.

answer: @entity3


abstract: The activities of @entity4 , @entity2 , @entity5 , @entity7 and @entity3 alone and in combination against 130 isolates of @entity0 , group B streptococci and @entity8 from @entity1 were assessed by using agar dilution, checkerboard and time-kill techniques. @entity7 and @entity3 were highly active against @entity0 and group B streptococci (MIC90 0.05-0.1 mg/1) but not active against List. monocytogenes. @entity4 was more active than @entity2 and @entity5 against group B streptococci (MIC90 0.1, 0.12 and 0.24 mg/l respectively) and @entity2 was the most active against List. monocytogenes (MIC90 0.6 mg/l). Every double @entity6 combination was synergistic for 3-14% of @entity0 , 8-26% of group B streptococci and 67-100% of List. monocytogenes in the checkerboard titration. The @entity3 combinations were less synergistic than the @entity7 combinations. In time-kill evaluations using concentrations representative for cerebrospinal fluid, the killing kinetics of @entity0 were not influenced by any combination. A significant delay in killing of group B streptococci was observed with @entity4 - @entity9 and @entity2 - @entity9 combinations. A significant increased killing of List. monocytogenes was observed with @entity4 - @entity9 combinations. The other combinations did not alter the killing kinetics of group B streptococci and List. monocytogenes.

title: Activity of @entity7 and @entity3 alone and in combination with penicillin, @entity2 and XXXX against @entity1 pathogens.

answer: @entity5


abstract: The activities of @entity4 , @entity2 , @entity5 , @entity7 and @entity3 alone and in combination against 130 isolates of @entity0 , group B streptococci and @entity8 from @entity1 were assessed by using agar dilution, checkerboard and time-kill techniques. @entity7 and @entity3 were highly active against @entity0 and group B streptococci (MIC90 0.05-0.1 mg/1) but not active against List. monocytogenes. @entity4 was more active than @entity2 and @entity5 against group B streptococci (MIC90 0.1, 0.12 and 0.24 mg/l respectively) and @entity2 was the most active against List. monocytogenes (MIC90 0.6 mg/l). Every double @entity6 combination was synergistic for 3-14% of @entity0 , 8-26% of group B streptococci and 67-100% of List. monocytogenes in the checkerboard titration. The @entity3 combinations were less synergistic than the @entity7 combinations. In time-kill evaluations using concentrations representative for cerebrospinal fluid, the killing kinetics of @entity0 were not influenced by any combination. A significant delay in killing of group B streptococci was observed with @entity4 - @entity9 and @entity2 - @entity9 combinations. A significant increased killing of List. monocytogenes was observed with @entity4 - @entity9 combinations. The other combinations did not alter the killing kinetics of group B streptococci and List. monocytogenes.

title: Activity of @entity7 and @entity3 alone and in combination with penicillin, XXXX and @entity5 against @entity1 pathogens.

answer: @entity2


abstract: The activities of @entity4 , @entity2 , @entity5 , @entity7 and @entity3 alone and in combination against 130 isolates of @entity0 , group B streptococci and @entity8 from @entity1 were assessed by using agar dilution, checkerboard and time-kill techniques. @entity7 and @entity3 were highly active against @entity0 and group B streptococci (MIC90 0.05-0.1 mg/1) but not active against List. monocytogenes. @entity4 was more active than @entity2 and @entity5 against group B streptococci (MIC90 0.1, 0.12 and 0.24 mg/l respectively) and @entity2 was the most active against List. monocytogenes (MIC90 0.6 mg/l). Every double @entity6 combination was synergistic for 3-14% of @entity0 , 8-26% of group B streptococci and 67-100% of List. monocytogenes in the checkerboard titration. The @entity3 combinations were less synergistic than the @entity7 combinations. In time-kill evaluations using concentrations representative for cerebrospinal fluid, the killing kinetics of @entity0 were not influenced by any combination. A significant delay in killing of group B streptococci was observed with @entity4 - @entity9 and @entity2 - @entity9 combinations. A significant increased killing of List. monocytogenes was observed with @entity4 - @entity9 combinations. The other combinations did not alter the killing kinetics of group B streptococci and List. monocytogenes.

title: Activity of @entity7 and @entity3 alone and in combination with penicillin, @entity2 and @entity5 against XXXX pathogens.

answer: @entity1


abstract: The activities of @entity4 , @entity2 , @entity5 , @entity7 and @entity3 alone and in combination against 130 isolates of @entity0 , group B streptococci and @entity8 from @entity1 were assessed by using agar dilution, checkerboard and time-kill techniques. @entity7 and @entity3 were highly active against @entity0 and group B streptococci (MIC90 0.05-0.1 mg/1) but not active against List. monocytogenes. @entity4 was more active than @entity2 and @entity5 against group B streptococci (MIC90 0.1, 0.12 and 0.24 mg/l respectively) and @entity2 was the most active against List. monocytogenes (MIC90 0.6 mg/l). Every double @entity6 combination was synergistic for 3-14% of @entity0 , 8-26% of group B streptococci and 67-100% of List. monocytogenes in the checkerboard titration. The @entity3 combinations were less synergistic than the @entity7 combinations. In time-kill evaluations using concentrations representative for cerebrospinal fluid, the killing kinetics of @entity0 were not influenced by any combination. A significant delay in killing of group B streptococci was observed with @entity4 - @entity9 and @entity2 - @entity9 combinations. A significant increased killing of List. monocytogenes was observed with @entity4 - @entity9 combinations. The other combinations did not alter the killing kinetics of group B streptococci and List. monocytogenes.

title: Activity of XXXX and @entity3 alone and in combination with penicillin, @entity2 and @entity5 against @entity1 pathogens.

answer: @entity7


abstract: @entity0 , surgically implanted with a chronic @entity6 , were chronically dosed with @entity7 (32 mg/kg/day) in four divided doses to attain @entity7 plasma levels comparable to those observed in @entity0 dependent on @entity4 (60 mg/kg/day). The time course of @entity7 abstinence was studied, beginning not less than 2 weeks after stabilization levels had been achieved. The abstinence syndrome observed after abrupt discontinuation of @entity7 was similar to the @entity4 abstinence syndrome but differed in several important aspects. In @entity4 -dependent @entity0 , there was a short burst of @entity1 very early in withdrawal (approximately 1-2 hr after the last dose of @entity4 ) that was not seen in @entity7 -dependent @entity0 . Signs of abstinence such as @entity1 , hot foot walking and twitches and jerks were more frequently observed in @entity7 -dependent @entity0 than in @entity4 -dependent @entity0 as were decreases in food and water intake and in body weight. The overall intensity of abstinence, as measured by the @entity4 Withdrawal Abstinence Scale, was greater in @entity7 -dependent @entity0 than in @entity0 dependent on either @entity3 or @entity4 . Plasma levels of @entity7 and @entity5 were nearly equal in @entity0 dependent on @entity4 or on @entity7 and were 4 to 10 times greater than the plasma levels of @entity4 or @entity3 in @entity4 - or @entity3 -dependent @entity0 , respectively. Furthermore, the plasma levels of @entity7 and @entity5 declined much more slowly than the levels of @entity4 and @entity3 . These results suggest that physical @entity2 on @entity4 is caused by the accumulation and actions of @entity7 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX physical @entity2 in @entity0 .

answer: @entity7


abstract: @entity0 , surgically implanted with a chronic @entity6 , were chronically dosed with @entity7 (32 mg/kg/day) in four divided doses to attain @entity7 plasma levels comparable to those observed in @entity0 dependent on @entity4 (60 mg/kg/day). The time course of @entity7 abstinence was studied, beginning not less than 2 weeks after stabilization levels had been achieved. The abstinence syndrome observed after abrupt discontinuation of @entity7 was similar to the @entity4 abstinence syndrome but differed in several important aspects. In @entity4 -dependent @entity0 , there was a short burst of @entity1 very early in withdrawal (approximately 1-2 hr after the last dose of @entity4 ) that was not seen in @entity7 -dependent @entity0 . Signs of abstinence such as @entity1 , hot foot walking and twitches and jerks were more frequently observed in @entity7 -dependent @entity0 than in @entity4 -dependent @entity0 as were decreases in food and water intake and in body weight. The overall intensity of abstinence, as measured by the @entity4 Withdrawal Abstinence Scale, was greater in @entity7 -dependent @entity0 than in @entity0 dependent on either @entity3 or @entity4 . Plasma levels of @entity7 and @entity5 were nearly equal in @entity0 dependent on @entity4 or on @entity7 and were 4 to 10 times greater than the plasma levels of @entity4 or @entity3 in @entity4 - or @entity3 -dependent @entity0 , respectively. Furthermore, the plasma levels of @entity7 and @entity5 declined much more slowly than the levels of @entity4 and @entity3 . These results suggest that physical @entity2 on @entity4 is caused by the accumulation and actions of @entity7 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity7 physical XXXX in @entity0 .

answer: @entity2


abstract: @entity0 , surgically implanted with a chronic @entity6 , were chronically dosed with @entity7 (32 mg/kg/day) in four divided doses to attain @entity7 plasma levels comparable to those observed in @entity0 dependent on @entity4 (60 mg/kg/day). The time course of @entity7 abstinence was studied, beginning not less than 2 weeks after stabilization levels had been achieved. The abstinence syndrome observed after abrupt discontinuation of @entity7 was similar to the @entity4 abstinence syndrome but differed in several important aspects. In @entity4 -dependent @entity0 , there was a short burst of @entity1 very early in withdrawal (approximately 1-2 hr after the last dose of @entity4 ) that was not seen in @entity7 -dependent @entity0 . Signs of abstinence such as @entity1 , hot foot walking and twitches and jerks were more frequently observed in @entity7 -dependent @entity0 than in @entity4 -dependent @entity0 as were decreases in food and water intake and in body weight. The overall intensity of abstinence, as measured by the @entity4 Withdrawal Abstinence Scale, was greater in @entity7 -dependent @entity0 than in @entity0 dependent on either @entity3 or @entity4 . Plasma levels of @entity7 and @entity5 were nearly equal in @entity0 dependent on @entity4 or on @entity7 and were 4 to 10 times greater than the plasma levels of @entity4 or @entity3 in @entity4 - or @entity3 -dependent @entity0 , respectively. Furthermore, the plasma levels of @entity7 and @entity5 declined much more slowly than the levels of @entity4 and @entity3 . These results suggest that physical @entity2 on @entity4 is caused by the accumulation and actions of @entity7 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity7 physical @entity2 in XXXX .

answer: @entity0


abstract: BACKGROUND: Although @entity1 and its corresponding therapies are associated with @entity5 , the temporal relationship between @entity1 and the development of coronary artery @entity3 (CAC), a marker of subclinical @entity4 , is unknown. METHODS AND RESULTS: Among 3122 @entity0 and @entity0 free of @entity2 and @entity1 in the Multi-Ethnic Study of @entity4 trial, CAC scoring was performed at baseline (2000-2002) and at follow-up (2010-2012). Over this 10-year period, 85 @entity0 (age 63.6  8.3 years) and 50 @entity0 (age 62.1  9.8 years) were diagnosed with @entity1 (predominantly breast, lung, or uterine [52%] in @entity0 and prostate or colorectal [78%] in @entity0 ). The other 2987 subjects (age 59.6  9.2 years for @entity0 , 59.7  9.4 years for @entity0 ) remained @entity1 free. The incidence of new CAC (baseline Agatston score of zero converting to detectable CAC) was modeled with relative risk regression and compared for @entity1 versus no @entity1 . Increase in pre-existing CAC was compared in these groups using linear regression of log transformed CAC. The incidence of CAC was independently associated with @entity1 history (relative risk 1.32 [P=0.04] and 1.29 [P=0.01] for @entity0 and @entity0 , respectively). In @entity0 with CAC at baseline, a clear difference of CAC progression was not observed between @entity1 and noncancer @entity0 (P=0.6 for @entity0 , P=0.2 for @entity0 ). CONCLUSIONS: A diagnosis of @entity1 is associated with the development of CAC even after accounting for @entity4 risk factors. However, in individuals with pre-existing CAC, it is not clear whether the presence of @entity1 accelerates CAC over time.

title: XXXX and Its Association With the Development of Coronary Artery Calcification: An Assessment From the Multi-Ethnic Study of @entity4 .

answer: @entity1


abstract: BACKGROUND: Although @entity1 and its corresponding therapies are associated with @entity5 , the temporal relationship between @entity1 and the development of coronary artery @entity3 (CAC), a marker of subclinical @entity4 , is unknown. METHODS AND RESULTS: Among 3122 @entity0 and @entity0 free of @entity2 and @entity1 in the Multi-Ethnic Study of @entity4 trial, CAC scoring was performed at baseline (2000-2002) and at follow-up (2010-2012). Over this 10-year period, 85 @entity0 (age 63.6  8.3 years) and 50 @entity0 (age 62.1  9.8 years) were diagnosed with @entity1 (predominantly breast, lung, or uterine [52%] in @entity0 and prostate or colorectal [78%] in @entity0 ). The other 2987 subjects (age 59.6  9.2 years for @entity0 , 59.7  9.4 years for @entity0 ) remained @entity1 free. The incidence of new CAC (baseline Agatston score of zero converting to detectable CAC) was modeled with relative risk regression and compared for @entity1 versus no @entity1 . Increase in pre-existing CAC was compared in these groups using linear regression of log transformed CAC. The incidence of CAC was independently associated with @entity1 history (relative risk 1.32 [P=0.04] and 1.29 [P=0.01] for @entity0 and @entity0 , respectively). In @entity0 with CAC at baseline, a clear difference of CAC progression was not observed between @entity1 and noncancer @entity0 (P=0.6 for @entity0 , P=0.2 for @entity0 ). CONCLUSIONS: A diagnosis of @entity1 is associated with the development of CAC even after accounting for @entity4 risk factors. However, in individuals with pre-existing CAC, it is not clear whether the presence of @entity1 accelerates CAC over time.

title: @entity1 and Its Association With the Development of Coronary Artery Calcification: An Assessment From the Multi-Ethnic Study of XXXX .

answer: @entity4


abstract: UNASSIGNED: Forward genetic screens using Sleeping Beauty (SB) mobilized T2/Onc transposons have been used to identify @entity7 ( @entity7 ) associated with @entity0 formation. Recurrent sites of transposon insertion are commonly identified using Ligation Mediated PCR (LM-PCR). Here, we use RNA-sequencing (RNA-seq) data to directly identify transcriptional events mediated by T2/Onc. Surprisingly, the majority (~80%) of LM-PCR identified junction fragments do not lead to observable changes in RNA transcripts. However, in @entity7 regions, direct transcriptional effects of transposon insertions are observed. We developed an automated method to systematically identify T2/Onc-genome RNA fusion sequences in RNA-seq data. RNA fusion based @entity7 were identified corresponding to both DNA based @entity7 ( @entity6 , @entity10 , @entity11 , @entity5 , @entity16 and @entity14 ) and additional regions strongly associated with @entity0 that were not observed by LM-PCR ( @entity2 , @entity3 , @entity1 , @entity8 , @entity9 , @entity15 , @entity12 and @entity13 ). In addition to calculating recurrent @entity7 , we also present complementary methods to identify potential driver events via determination of strongly supported fusions and fusions with large transcript level changes in the absence of multi- @entity0 recurrence. These methods independently identify @entity7 regions, and also point to @entity0 -associated genes like @entity4 . We anticipate RNA-seq analyses of @entity0 from forward genetic screens will become an efficient tool to identify causal events.

title: RNA sequencing of Sleeping Beauty transposon-induced XXXX detect transposon-RNA fusions allowing precision analyses of forward @entity0 screens.

answer: @entity0


abstract: UNASSIGNED: Forward genetic screens using Sleeping Beauty (SB) mobilized T2/Onc transposons have been used to identify @entity7 ( @entity7 ) associated with @entity0 formation. Recurrent sites of transposon insertion are commonly identified using Ligation Mediated PCR (LM-PCR). Here, we use RNA-sequencing (RNA-seq) data to directly identify transcriptional events mediated by T2/Onc. Surprisingly, the majority (~80%) of LM-PCR identified junction fragments do not lead to observable changes in RNA transcripts. However, in @entity7 regions, direct transcriptional effects of transposon insertions are observed. We developed an automated method to systematically identify T2/Onc-genome RNA fusion sequences in RNA-seq data. RNA fusion based @entity7 were identified corresponding to both DNA based @entity7 ( @entity6 , @entity10 , @entity11 , @entity5 , @entity16 and @entity14 ) and additional regions strongly associated with @entity0 that were not observed by LM-PCR ( @entity2 , @entity3 , @entity1 , @entity8 , @entity9 , @entity15 , @entity12 and @entity13 ). In addition to calculating recurrent @entity7 , we also present complementary methods to identify potential driver events via determination of strongly supported fusions and fusions with large transcript level changes in the absence of multi- @entity0 recurrence. These methods independently identify @entity7 regions, and also point to @entity0 -associated genes like @entity4 . We anticipate RNA-seq analyses of @entity0 from forward genetic screens will become an efficient tool to identify causal events.

title: RNA sequencing of Sleeping Beauty transposon-induced @entity0 detect transposon-RNA fusions allowing precision analyses of forward XXXX screens.

answer: @entity0


abstract: A 42-year-old @entity0 was transferred to our hospital for evaluation of @entity11 with a complete @entity8 . Her pulse was 41 regular beats/min with blood pressure 166/92 mmHg. There were no @entity4 , @entity1 , or @entity15 . The white blood cell count was 6300/mm3. The serum glutamic oxaloacetic transaminase was 21 IU and @entity9 phosphokinase was 34 IU. @entity13 was negative. The level of serum @entity12 was slightly increased at 25.8 IU/l/37.0 degrees C (normal range: 7-24.0). Chest radiography showed @entity7 with a cardiothoracic ratio of 54%. There was no bilateral @entity15 or fibrous changes during her clinical course. The coronary arteries were completely normal angiographically. Left ventriculograms revealed slight hypokinesis and @entity6 (end-diastolic volume index of 112 ml/m2, ejection fraction of 53%). Left ventricular end-diastolic pressure was slightly abnormal at 16 mmHg. Two right and two left ventricular endomyocardial biopsies were performed. Right ventricular biopsy demonstrated @entity1 tissue and a slight mononuclear cell infiltration with little @entity3 . Left ventricular specimens showed an extensive area of @entity3 , with large, multinucleated giant cells with an @entity10 and @entity2 without epithelioid cells. The less affected areas of another specimen showed mild @entity3 and degenerative myocytes with vacuolation, and some multinucleated myocytes without an @entity10 were present. This case was diagnosed as @entity5 rather than @entity14 . The @entity0 has been implanted with a permanent pacemaker.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX with multinucleated giant cells detected in biopsy specimens.

answer: @entity14


abstract: To test the effects of @entity1 receptor blockade on @entity4 (BN)-induced behavioural changes, adult male @entity0 were administered @entity2 (0.01, 0.025, 0.1, 0.25 mg/kg, IP) followed 30 min later by BN (1 micrograms in 5 microliter) or saline (5 microliter) intracerebroventricularly (ICV). Subsequent behavioural effects were monitored in chambers equipped with strategically located infrared beam grids, controlled by a microprocessor. The following behaviours were monitored: locomotor activity (distance traversed), floor activity (horizontal or lateral displacement) and rearing activity (frequency of vertical displacement extending 17.8 cm above the floor). At all but the highest dose (0.25 mg/kg, which suppressed floor activity), @entity2 failed to significantly alter any of the behavioural parameters monitored. Whereas at doses of 0.025 or lower, @entity2 failed to alter BN-induced behavioural output, at doses of 0.1 mg/kg or greater, it significantly blocked the behavioural effects BN. In the next experiment, @entity1 neurons of adult male @entity0 were lesioned using @entity3 ( @entity3 ) (250 micrograms/10 microliter, ICV). The @entity3 and sham-lesioned (control) @entity0 were administered BN (0.001, 0.01, 0.1 or 1.0 microgram, ICV) and their behaviour monitored. In the control animals, BN stimulated locomotor, floor and rearing activity in a dose-dependent manner. However, these behavioural effects of BN were markedly attenuated or absent in the @entity3 -lesioned animals. These data further support our contention that centrally administered BN may mediate its behavioural effects, through the dopaminergic system(s).

title: Role of dopaminergic system(s) in mediation of the behavioural effects of XXXX .

answer: @entity4


abstract: BACKGROUND: Calcific @entity2 ( @entity5 ) is a life-threatening disease with no medical therapy. The genetic architecture of @entity5 remains elusive. This study combines genome-wide association studies, gene expression, and expression quantitative trait loci mapping in @entity0 valve tissues to identify susceptibility genes of @entity5 . METHODS AND RESULTS: A meta-analysis was performed combining the results of 2 genome-wide association studies in 474 and 486 cases from Quebec City (Canada) and Paris (France), respectively. Corresponding controls consisted of 2988 and 1864 individuals with European ancestry from the database of genotypes and phenotypes. mRNA expression levels were evaluated in 9 calcified and 8 normal aortic valves by RNA sequencing. The results were integrated with valve expression quantitative trait loci data obtained from 22 @entity5 @entity0 . Twenty-five single- @entity3 polymorphisms had P<5*10(-6) in the genome-wide association studies meta-analysis. The @entity1 signaling pathway was the top gene set enriched for genes mapped to moderately @entity5 -associated single-nucleotide polymorphisms. Genes in this pathway were found differentially expressed in valves with and without @entity5 . Two single-nucleotide polymorphisms located in @entity4 ( @entity4 ), encoding an osteogenic transcription factor, demonstrated some association with @entity5 (genome-wide association studies P=5.33*10(-5)). The mRNA expression levels of @entity4 were upregulated in calcified valves and associated with eQTL-SNPs. @entity6 encoding a subunit of a voltage-dependent @entity1 channel was upregulated in calcified valves. The eQTL-SNP with the most significant association with @entity5 located in @entity6 was associated with higher expression of the gene. CONCLUSIONS: This integrative genomic study confirmed the role of @entity4 as a potential driver of @entity5 and identified a new @entity5 susceptibility gene, @entity6 , belonging to the @entity1 signaling pathway.

title: @entity1 Signaling Pathway Genes XXXX and @entity6 Are Associated With Calcific Aortic Valve Disease.

answer: @entity4


abstract: BACKGROUND: Calcific @entity2 ( @entity5 ) is a life-threatening disease with no medical therapy. The genetic architecture of @entity5 remains elusive. This study combines genome-wide association studies, gene expression, and expression quantitative trait loci mapping in @entity0 valve tissues to identify susceptibility genes of @entity5 . METHODS AND RESULTS: A meta-analysis was performed combining the results of 2 genome-wide association studies in 474 and 486 cases from Quebec City (Canada) and Paris (France), respectively. Corresponding controls consisted of 2988 and 1864 individuals with European ancestry from the database of genotypes and phenotypes. mRNA expression levels were evaluated in 9 calcified and 8 normal aortic valves by RNA sequencing. The results were integrated with valve expression quantitative trait loci data obtained from 22 @entity5 @entity0 . Twenty-five single- @entity3 polymorphisms had P<5*10(-6) in the genome-wide association studies meta-analysis. The @entity1 signaling pathway was the top gene set enriched for genes mapped to moderately @entity5 -associated single-nucleotide polymorphisms. Genes in this pathway were found differentially expressed in valves with and without @entity5 . Two single-nucleotide polymorphisms located in @entity4 ( @entity4 ), encoding an osteogenic transcription factor, demonstrated some association with @entity5 (genome-wide association studies P=5.33*10(-5)). The mRNA expression levels of @entity4 were upregulated in calcified valves and associated with eQTL-SNPs. @entity6 encoding a subunit of a voltage-dependent @entity1 channel was upregulated in calcified valves. The eQTL-SNP with the most significant association with @entity5 located in @entity6 was associated with higher expression of the gene. CONCLUSIONS: This integrative genomic study confirmed the role of @entity4 as a potential driver of @entity5 and identified a new @entity5 susceptibility gene, @entity6 , belonging to the @entity1 signaling pathway.

title: XXXX Signaling Pathway Genes @entity4 and @entity6 Are Associated With Calcific Aortic Valve Disease.

answer: @entity1


abstract: BACKGROUND: Calcific @entity2 ( @entity5 ) is a life-threatening disease with no medical therapy. The genetic architecture of @entity5 remains elusive. This study combines genome-wide association studies, gene expression, and expression quantitative trait loci mapping in @entity0 valve tissues to identify susceptibility genes of @entity5 . METHODS AND RESULTS: A meta-analysis was performed combining the results of 2 genome-wide association studies in 474 and 486 cases from Quebec City (Canada) and Paris (France), respectively. Corresponding controls consisted of 2988 and 1864 individuals with European ancestry from the database of genotypes and phenotypes. mRNA expression levels were evaluated in 9 calcified and 8 normal aortic valves by RNA sequencing. The results were integrated with valve expression quantitative trait loci data obtained from 22 @entity5 @entity0 . Twenty-five single- @entity3 polymorphisms had P<5*10(-6) in the genome-wide association studies meta-analysis. The @entity1 signaling pathway was the top gene set enriched for genes mapped to moderately @entity5 -associated single-nucleotide polymorphisms. Genes in this pathway were found differentially expressed in valves with and without @entity5 . Two single-nucleotide polymorphisms located in @entity4 ( @entity4 ), encoding an osteogenic transcription factor, demonstrated some association with @entity5 (genome-wide association studies P=5.33*10(-5)). The mRNA expression levels of @entity4 were upregulated in calcified valves and associated with eQTL-SNPs. @entity6 encoding a subunit of a voltage-dependent @entity1 channel was upregulated in calcified valves. The eQTL-SNP with the most significant association with @entity5 located in @entity6 was associated with higher expression of the gene. CONCLUSIONS: This integrative genomic study confirmed the role of @entity4 as a potential driver of @entity5 and identified a new @entity5 susceptibility gene, @entity6 , belonging to the @entity1 signaling pathway.

title: @entity1 Signaling Pathway Genes @entity4 and XXXX Are Associated With Calcific Aortic Valve Disease.

answer: @entity6


abstract: The literature on incarceration in @entity5 in adults is rather limited. Our purpose is to present two cases of this lesion that were treated surgically in the past ten years. The first @entity0 , a 32 year old female was admitted in shock with an 8h history of left @entity2 and dyspnoea. Chest X-ray showed a @entity3 in the left hemithorax. Chest tube drainage revealed gastric fluid. We operated on her immediately, through a left thoracotomy, and found @entity1 of the stomach into the left @entity3 . Strangulation of the fundus of the stomach due to @entity5 , Bochdalek's type, was found to be the cause of the @entity1 . We performed resection of the gangrenous segment of the stomach with primary closure. The second @entity0 a 48 year old @entity0 was admitted with symptoms of @entity4 . Per os gastrographin study showed the splenic flexure herniated into the left hemithorax. At the operation, through a paramedian left incision, the herniated large bowel was reduced back into the abdomen. In both cases the defect of the left hemidiaphragm was sutured with interrupted silk sutures. Both @entity0 had an uneventful postoperative course. The diagnosis of @entity5 in the adult is usually made in case of complications, and that demands an immediate surgical repair.

title: Complications of XXXX in the adult. Report of two cases and literature review.

answer: @entity5


abstract: The aim of this study was to gain experience regarding the efficacy and safety of @entity2 400 mg nightly for the long-term maintenance treatment of peptic @entity1 three years. The trial was carried out in 44 centres in 12 countries. 1988 @entity0 with endoscopically-proven peptic ulceration initially underwent an acute treatment over 6-12 weeks (open study) with 1000 mg @entity2 -the dosage could be increased to 1600 mg daily if necessary. After 6 weeks, 81% of @entity0 had healed @entity1 and the cumulative healing rate after 12 weeks rose to 95%. The statistical analysis of the subsequent long-term maintenance treatment was based on data from 1726 @entity0 (82% with healed pyloric or duodenal @entity1 ; 16% with ulcus ventriculi and 2% with @entity1 subsequent to stomach surgery) who received 400 mg @entity2 nightly over 3 years. Based on life-table analysis, @entity0 who received 400 mg @entity2 nightly during the entire length of the study showed relapse rates of 25%, 36% and 45% after 1, 2 and 3 years respectively. The effect of various prognostic factors on the ulcer relapse rate was examined. @entity0 who smoked or who were younger than 50 years suffered significantly more relapses and @entity0 with duodenal @entity1 also relapsed more frequently. After the open-design long-term maintenance treatment study had been continued over 2 years, one-fifth of the @entity0 who had remained relapse-free were randomly assigned to placebo for one year. In the 3rd year, 36% in the placebo group and 16% of the @entity0 who had continued with @entity2 had relapsed. This difference is statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Long term XXXX therapy for the prevention of recurring peptic ulcer: a multicenter study.

answer: @entity2


abstract: To establish the effects of a meal on portal venous flow and the prognostic value of this parameter, 46 @entity0 with @entity1 and 28 healthy subjects were examined with duplex Doppler before and after a meal. The measurements were completed in 40 @entity0 and 21 healthy subjects. Postprandial portal venous diameter, blood velocity and quantitative flow were measured for 60 min. Mean baseline values were: 11.4 mm versus 10.2 mm (p = 0.019), 10.8 cm.s-1 versus 13.4 cm.s-1 (p = 0.015) and 668 ml. @entity3 versus 646 ml. @entity3 (p = 0.7) respectively. Spleen size was 15.0 cm versus 10.6 cm (p = 0.0001) respectively. Postprandial diameter, velocity and flow increased significantly in @entity0 and controls (p = 0.0001 for all). Mean postprandial flow could best be described by a polynomial equation with a parabolic curve. @entity0 ' curves were more blunted than controls', with significantly different regression constants (p = 0.025 and p = 0.029). All subjects were followed up for survival and variceal @entity2 . The mean follow-up time was 47 months. Early maximum postprandial velocity (p = 0.041) and large spleen size (p = 0.002) were significantly related to an unfavourable prognosis for survival. Early maximum velocity was also related to @entity2 . This study shows that postprandial portal venous flow is blunted in @entity0 with @entity1 . Postprandial portal venous flow may have prognostic significance.

title: Blunted postprandial reaction of portal venous flow in XXXX , assessed with duplex Doppler: significance for prognosis.

answer: @entity1


abstract: Regulation of the closely linked endogenous @entity2 @entity6 , MT-Ib, @entity7 and @entity5 genes by heavy metals and @entity1 was studied in cultured @entity2 fibroblasts. Only @entity5 mRNA was detectable before addition of any inducer. Addition of @entity3 , @entity0 or @entity4 salts to the culture medium increased the level of each mRNA; however, the magnitude of this response varied greatly between the four metallothionein genes. Following induction, levels of @entity6 mRNA were the highest, followed by @entity5 and @entity7 mRNAs. The MT-Ib mRNA was only present at low levels. @entity0 and @entity4 were found to be the most effective inducers of each gene. The maximal response of the sMT-Ia, Ib and II genes to @entity3 was only 30% of @entity0 and @entity4 . The sMT-Ic gene responded very weakly to @entity3 , less than 5% of the levels achieved with @entity0 . Only the @entity5 mRNA increased in response to @entity1 . In the liver of @entity2 on normal diets, the levels of @entity6 , Ic and II mRNAs were found to be unexpectedly high and comparable to induced levels in fibroblasts.

title: Differential expression of four linked XXXX metallothionein genes.

answer: @entity2


abstract: The effect of a selective @entity6 (TX) synthetase inhibitor ( @entity7 ), alone and in combination with a very low dose of @entity3 , on the platelet function was studied in healthy and diseased subjects. A single dose of 100 mg @entity7 was orally administered to @entity0 with @entity1 ( @entity2 ) and healthy volunteers. TXB2 generation and @entity4 were measured before and at 1, 4, 6 and 8hr after dosing. In addition, after the administration of a very low dose of @entity3 (0.1-0.25 mg/kg/day) for at least one month, a single dose of @entity7 was given to @entity2 @entity0 . TXB2 generation and @entity4 were measured in the same manner as @entity7 alone. The effect of @entity7 on @entity4 induced by @entity5 (AA) was different in each subject whereas platelet TXB2 generation was almost completely inhibited in all of the @entity0 and healthy volunteers. @entity7 had a slight inhibitory effect on collagen induced aggregation. A combination of @entity7 with a very low dose of @entity3 , on the other hand, produced additional inhibition of the @entity4 induced by both AA and collagen. The present results suggest that the accumulation and metabolism of cyclooxygenase products that accumulate when TX synthetase is blocked, differ in each subject, additional inhibition is caused by the combined use of TX synthetase inhibitor and a very low dose of @entity3 because the very low dose of @entity3 partially reduces the proaggregatory cyclooxygenase products that accumulate when TX synthetase is blocked.(ABSTRACT TRUNCATED AT 250 WORDS)

title: A new approach to antithrombotic therapy--evaluation of combined therapy of @entity6 synthetase inhibitor and very low dose of XXXX .

answer: @entity3


abstract: The effect of a selective @entity6 (TX) synthetase inhibitor ( @entity7 ), alone and in combination with a very low dose of @entity3 , on the platelet function was studied in healthy and diseased subjects. A single dose of 100 mg @entity7 was orally administered to @entity0 with @entity1 ( @entity2 ) and healthy volunteers. TXB2 generation and @entity4 were measured before and at 1, 4, 6 and 8hr after dosing. In addition, after the administration of a very low dose of @entity3 (0.1-0.25 mg/kg/day) for at least one month, a single dose of @entity7 was given to @entity2 @entity0 . TXB2 generation and @entity4 were measured in the same manner as @entity7 alone. The effect of @entity7 on @entity4 induced by @entity5 (AA) was different in each subject whereas platelet TXB2 generation was almost completely inhibited in all of the @entity0 and healthy volunteers. @entity7 had a slight inhibitory effect on collagen induced aggregation. A combination of @entity7 with a very low dose of @entity3 , on the other hand, produced additional inhibition of the @entity4 induced by both AA and collagen. The present results suggest that the accumulation and metabolism of cyclooxygenase products that accumulate when TX synthetase is blocked, differ in each subject, additional inhibition is caused by the combined use of TX synthetase inhibitor and a very low dose of @entity3 because the very low dose of @entity3 partially reduces the proaggregatory cyclooxygenase products that accumulate when TX synthetase is blocked.(ABSTRACT TRUNCATED AT 250 WORDS)

title: A new approach to antithrombotic therapy--evaluation of combined therapy of XXXX synthetase inhibitor and very low dose of @entity3 .

answer: @entity6


abstract: OBJECTIVE: To document the radiologic abnormalities in @entity0 with @entity2 onset @entity3 (SOJRA) including abnormalities occurring early in the course of disease. METHODS: A retrospective review of the charts and radiographs of 42 consecutive @entity0 with SOJRA was carried out. Radiographs were reviewed by a single experienced radiologist with no knowledge of the clinical course of the @entity0 . RESULTS: Soft tissue swelling and @entity1 were the most common radiologic abnormalities (34/42; 81%). @entity4 were also common, occurring in 50% of @entity0 . @entity7 occurred within 2 years of disease onset in 11/36 (31%). @entity6 and @entity5 within 2 years of disease onset preceded @entity7 in 11 @entity0 with serial radiographs. Severe radiologic abnormalities included joint @entity8 (8/42; 19%), subluxation (9/42; 21%), and protrusio acetabuli (4/42; 10%). Joint @entity8 occurred most commonly between 3 and 5 years after disease onset and subluxation between 2 and 6 years. CONCLUSION: A subgroup of @entity0 with SOJRA develops early destructive radiologic changes whose severity is comparable to those of @entity0 with @entity9 . Early subchondral changes may be predictive of subsequent erosive disease in SOJRA and require prospective study using newer imaging techniques.

title: Radiologic features of XXXX onset @entity3 .

answer: @entity2


abstract: OBJECTIVE: To document the radiologic abnormalities in @entity0 with @entity2 onset @entity3 (SOJRA) including abnormalities occurring early in the course of disease. METHODS: A retrospective review of the charts and radiographs of 42 consecutive @entity0 with SOJRA was carried out. Radiographs were reviewed by a single experienced radiologist with no knowledge of the clinical course of the @entity0 . RESULTS: Soft tissue swelling and @entity1 were the most common radiologic abnormalities (34/42; 81%). @entity4 were also common, occurring in 50% of @entity0 . @entity7 occurred within 2 years of disease onset in 11/36 (31%). @entity6 and @entity5 within 2 years of disease onset preceded @entity7 in 11 @entity0 with serial radiographs. Severe radiologic abnormalities included joint @entity8 (8/42; 19%), subluxation (9/42; 21%), and protrusio acetabuli (4/42; 10%). Joint @entity8 occurred most commonly between 3 and 5 years after disease onset and subluxation between 2 and 6 years. CONCLUSION: A subgroup of @entity0 with SOJRA develops early destructive radiologic changes whose severity is comparable to those of @entity0 with @entity9 . Early subchondral changes may be predictive of subsequent erosive disease in SOJRA and require prospective study using newer imaging techniques.

title: Radiologic features of @entity2 onset XXXX .

answer: @entity3


abstract: @entity6 and @entity7 are injected during endoscopic sclerotherapy to control variceal @entity1 . When administered to @entity2 they cause transient @entity0 and increase protein poor lung lymph flow. To determine the etiology of these alterations, we studied three groups of @entity2 after establishing acute lung lymph fistulas. In Group 1, @entity4 or @entity5 was infused. In Group 2, 2.5 cc of @entity6 was injected alone (2A) or after @entity4 or @entity5 pretreatment (2B). In Group 3, 2.5 cc of @entity7 was given intravenously either alone (3A) or after @entity4 or @entity5 (3B). When sclerosing agents were given alone (Group 2A and 3A) pulmonary artery pressures increased three-fold at 30 seconds postinjection to 37 +/- 4.4 and 39 +/- 5.7 mmHg respectively with a slow return to baseline over two hours. Lymph flow increased significantly from 1.3 +/- 1.5 to 2.7 +/- 1.5 cc/30 minutes after @entity6 and from 1.2 +/- .62 to 2.7 +/- 1.7 cc/30 mins at 30 minutes after @entity7 and the lymph/plasma albumin ratio fell. Increased lymph flow persisted through 120 minutes. In those animals receiving a sclerosing agent after @entity4 or @entity5 (2B and 3B) there was no change in pulmonary artery pressure, lymph flow, lymph plasma albumin ratio, or lung wet weight to dry weight ratios. We conclude that the @entity0 and increased protein poor lymph flow are mediated by @entity3 .

title: The XXXX of sclerosing agents is prevented by cyclooxygenase inhibitors.

answer: @entity0


abstract: Pressure activity in the rectum and anal canal was measured with a multilumen probe in 29 @entity0 with @entity1 (12 active, 11 quiescent, six studied during both phases) and 18 normal controls under resting conditions and during rectal infusion of saline. Resting motor activity was significantly decreased in @entity0 with @entity3 compared with quiescent @entity3 (p less than 0.005) and normal controls (p less than 0.001). Forty per cent of active colitics showed a featureless record compared with only one @entity0 with quiescent @entity3 and one normal subject. The volume of saline infused before leakage occurred, and the total volume retained were significantly lower (p less than 0.001) in @entity0 with active and quiescent @entity3 compared with normal controls. Rectal infusion of saline provoked regular rectal contractions, of significantly higher (p less than 0.05) amplitude in @entity0 with @entity3 , than in quiescent @entity3 or controls. These rectal contractions were associated with simultaneous anal relaxations. During saline infusion, peak and pressures were lower in @entity0 with @entity1 than in normal subjects, but there were no significant differences in relaxation pressures. In normal subjects, the rectal pressures remained below the anal pressures throughout the saline infusion. Peak rectal pressures exceeded the anal relaxation pressures during the last five minutes of saline infusion in @entity0 with @entity1 and throughout the infusion in those @entity0 who complained of @entity2 . Results suggest that although the resting rectal motor activity is diminished in @entity0 with @entity1 , luminal distension causes the inflamed rectum to generate abnormally strong contractions that may threaten continence.

title: Anorectal contractility under basal conditions and during rectal infusion of saline in XXXX .

answer: @entity1


abstract: Evidence suggests that @entity4 may ultimately be the result of excessive intracellular @entity3 accumulation. In principle, abnormal @entity3 concentrations during @entity1 are derived from three main sources: exaggerated influx via (a) voltage-operated channels, (b) receptor-controlled channels (f. ex. @entity2 ) and (c) the release of intracellular @entity3 ion stores. Previous studies using either @entity3 channel blockers or @entity2 antagonists have demonstrated only limited protective effects of these agents in global transient @entity11 , whereas little or no attention has been paid to the @entity3 sources listed under (c). @entity6 has been shown to block the increase in free intracellular @entity3 ion stimulated by either @entity2 or @entity10 . Thus we postulated that @entity6 might improve neuronal survival in vulnerable regions to @entity1 such as the @entity7 hippocampus. Male @entity0 (300 approximately 400 g) were prepared for a four-vessel occlusion model of @entity11 . @entity11 was induced by snaring the carotid arteries for 15 mins and maintaining mean arterial pressure at 80 mmHg. Strict attention was paid to keep normal blood gas values. Following @entity1 @entity8 anesthesia was discontinued, and @entity0 were extubated and when stable transferred to cages with free access to water and food. @entity0 survived for 7 days under close supervision, after which they were anesthetized with @entity12 and perfused transcardially with 4% @entity9 / @entity13 buffer. The brain was removed and placed in fresh fixatives for another 7 days, after which 40 microns sections were cut and @entity5 -stained.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Effects of XXXX on histological and behavioral outcome in @entity0 @entity7 hippocampus after global transient @entity11 ].

answer: @entity6


abstract: Evidence suggests that @entity4 may ultimately be the result of excessive intracellular @entity3 accumulation. In principle, abnormal @entity3 concentrations during @entity1 are derived from three main sources: exaggerated influx via (a) voltage-operated channels, (b) receptor-controlled channels (f. ex. @entity2 ) and (c) the release of intracellular @entity3 ion stores. Previous studies using either @entity3 channel blockers or @entity2 antagonists have demonstrated only limited protective effects of these agents in global transient @entity11 , whereas little or no attention has been paid to the @entity3 sources listed under (c). @entity6 has been shown to block the increase in free intracellular @entity3 ion stimulated by either @entity2 or @entity10 . Thus we postulated that @entity6 might improve neuronal survival in vulnerable regions to @entity1 such as the @entity7 hippocampus. Male @entity0 (300 approximately 400 g) were prepared for a four-vessel occlusion model of @entity11 . @entity11 was induced by snaring the carotid arteries for 15 mins and maintaining mean arterial pressure at 80 mmHg. Strict attention was paid to keep normal blood gas values. Following @entity1 @entity8 anesthesia was discontinued, and @entity0 were extubated and when stable transferred to cages with free access to water and food. @entity0 survived for 7 days under close supervision, after which they were anesthetized with @entity12 and perfused transcardially with 4% @entity9 / @entity13 buffer. The brain was removed and placed in fresh fixatives for another 7 days, after which 40 microns sections were cut and @entity5 -stained.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Effects of @entity6 on histological and behavioral outcome in @entity0 @entity7 hippocampus after global transient XXXX ].

answer: @entity11


abstract: Evidence suggests that @entity4 may ultimately be the result of excessive intracellular @entity3 accumulation. In principle, abnormal @entity3 concentrations during @entity1 are derived from three main sources: exaggerated influx via (a) voltage-operated channels, (b) receptor-controlled channels (f. ex. @entity2 ) and (c) the release of intracellular @entity3 ion stores. Previous studies using either @entity3 channel blockers or @entity2 antagonists have demonstrated only limited protective effects of these agents in global transient @entity11 , whereas little or no attention has been paid to the @entity3 sources listed under (c). @entity6 has been shown to block the increase in free intracellular @entity3 ion stimulated by either @entity2 or @entity10 . Thus we postulated that @entity6 might improve neuronal survival in vulnerable regions to @entity1 such as the @entity7 hippocampus. Male @entity0 (300 approximately 400 g) were prepared for a four-vessel occlusion model of @entity11 . @entity11 was induced by snaring the carotid arteries for 15 mins and maintaining mean arterial pressure at 80 mmHg. Strict attention was paid to keep normal blood gas values. Following @entity1 @entity8 anesthesia was discontinued, and @entity0 were extubated and when stable transferred to cages with free access to water and food. @entity0 survived for 7 days under close supervision, after which they were anesthetized with @entity12 and perfused transcardially with 4% @entity9 / @entity13 buffer. The brain was removed and placed in fresh fixatives for another 7 days, after which 40 microns sections were cut and @entity5 -stained.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Effects of @entity6 on histological and behavioral outcome in @entity0 XXXX hippocampus after global transient @entity11 ].

answer: @entity7


abstract: Evidence suggests that @entity4 may ultimately be the result of excessive intracellular @entity3 accumulation. In principle, abnormal @entity3 concentrations during @entity1 are derived from three main sources: exaggerated influx via (a) voltage-operated channels, (b) receptor-controlled channels (f. ex. @entity2 ) and (c) the release of intracellular @entity3 ion stores. Previous studies using either @entity3 channel blockers or @entity2 antagonists have demonstrated only limited protective effects of these agents in global transient @entity11 , whereas little or no attention has been paid to the @entity3 sources listed under (c). @entity6 has been shown to block the increase in free intracellular @entity3 ion stimulated by either @entity2 or @entity10 . Thus we postulated that @entity6 might improve neuronal survival in vulnerable regions to @entity1 such as the @entity7 hippocampus. Male @entity0 (300 approximately 400 g) were prepared for a four-vessel occlusion model of @entity11 . @entity11 was induced by snaring the carotid arteries for 15 mins and maintaining mean arterial pressure at 80 mmHg. Strict attention was paid to keep normal blood gas values. Following @entity1 @entity8 anesthesia was discontinued, and @entity0 were extubated and when stable transferred to cages with free access to water and food. @entity0 survived for 7 days under close supervision, after which they were anesthetized with @entity12 and perfused transcardially with 4% @entity9 / @entity13 buffer. The brain was removed and placed in fresh fixatives for another 7 days, after which 40 microns sections were cut and @entity5 -stained.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Effects of @entity6 on histological and behavioral outcome in XXXX @entity7 hippocampus after global transient @entity11 ].

answer: @entity0


abstract: Epstein's triad which is a syndrome with the combination of @entity13 , @entity10 and @entity9 , is similar to @entity12 . We report on a case of @entity14 and describe the results of morphological examination of a renal biopsy, specimen. The @entity0 was a 14-year-old @entity0 with the diagnosis of @entity11 that had preseated from the age of 3 years. She was referred to Daisan Hospital of the Jikei University School of Medicine on April 1, 1991 for @entity6 . She had shown @entity8 since the age of 6 years and her peripheral blood smear revealed giant platelets on admission. She was treated with interferon, @entity3 , and high-dose gamma-globulin (400 mg/day x 5 days). However, the platelet count did not increase, but @entity7 continued. She subsequently showed @entity4 and @entity5 . She underwent splenectomy and renal biopsy on August 12, 1992. The glomeruli appeared to be almost normal under light microscopy. The interstitium showed regional @entity1 containing foam cells and the renal tubuli showed mild @entity2 . Under electronmicroscopy, the basement membrane of the glomeruli was associated with mesangial interposition and the lamina densa was split into several layers. These ultrastructural findings were compatible with those of @entity12 .

title: [A case report of XXXX ].

answer: @entity14


abstract: The pathological assessment of the pulmonary vascular bed is essential for the diagnosis and management of @entity3 with @entity2 . To investigate the relationship between @entity6 ( @entity6 ) findings and the Heath-Edwards (H.E.) grade of @entity0 pulmonary arteries, 40 pulmonary arterial segments from 17 autopsies and 5 @entity0 with @entity2 were evaluated using a high-frequency @entity6 imaging system. Histological observations were carried out at the same sites that were examined with @entity6 and at the distal pulmonary arterioles of the same branches. The subjects were subdivided into 3 groups-group I: 7 @entity0 with @entity2 (20 segments); group II: 10 @entity0 without @entity2 (20 segments); and group III: 5 @entity0 with @entity2 who were studied in vivo. All 20 segments from group I had a three-layered appearance, and 3 @entity0 with H.E. grade < 3 had an increased thickness of the echolucent zone due to media @entity4 without an intimal reaction. In contrast, @entity6 findings from @entity0 with severe @entity2 (H.E. grade > or = 3) showed an increased thickness with a bright inner layer due to intima @entity5 . Evidence for @entity1 was defined in one @entity0 with severe @entity2 . The percentage of wall thickness derived from @entity6 was significantly correlated with that determined by histological examination in group I. The pulmonary artery walls in group II had a one-layer appearance. Similar @entity6 findings were obtained from the in vivo study regardless of whether @entity2 was present. These findings indicate that the @entity6 may be an unique technique for evaluating the morphology of the pulmonary artery or arteriole in @entity2 and may provide objective and quantitative evaluation without a lung biopsy.

title: Wall morphology of the pulmonary artery-- XXXX imaging and pathological evaluations.

answer: @entity6


abstract: A total of 234 @entity0 of @entity1 treated at 7 institutions from 1972 through 1985 were analyzed. Male to female ratio was 157: 77, mean age was 39.8 years, and overall 5- and 10-year survival were 67% and 56%, respectively. Of 126 @entity0 treated by radiotherapy with more than 36 Gy, alone or preceded to other treatments, 5- and 10-year survival rates were 84% and 80% for Stage I (43 @entity0 ), 79% and 69% for Stage II (71 pts.), and 52% and none for Stage III (12 pts.), respectively. Survival rate was better for LP, NS and MC histologies as compared to LD, better for @entity0 without constitutional symptoms, as compared to @entity0 with B, and better for @entity0 with ages younger than 59 years as compared to those with ages over 60 years. Relapse was observed in 57 out of 126 @entity0 . Relapse within the irradiation field was observed in only 4, and nodal areas outside the field, especially of abdomen (1/3), were the most common sites. Half of the relapses occurred within 20 months, and 80%, 40 months. Five-year survival of @entity0 after relapse to lower torso lymph nodes (19 @entity0 ) was 37%, which was worse than @entity0 after relapse to upper torso lymph nodes (15 @entity0 : 63%) (z = 1.507, N.S.).

title: [Results of the radiotherapy of XXXX (a JLRTG report). Japan Lymphoma Radiation Therapy Group].

answer: @entity1


abstract: A 42-year-old @entity0 was referred to this institution because of persistent air leak associated with @entity6 . She had undergone a radical hysterectomy with bilateral oophorectomy and left nephrectomy one year previously. The @entity3 was identified as an @entity2 . This, along with the characteristic dermal lesions led to the diagnosis of @entity4 . Preoperative thin-slice chest CT showed multiple thin-walled, round and cystic air spaces in the @entity1 bilaterally, as well as the left pneumothorax. Through a left thoracotomy, suture ligation and laser ablation of the @entity1 was done. Examination of the biopsy specimen of the lung showed hamartoangiomyomatosis with @entity5 . The proliferating smooth muscle in the walls of the bullae was positively stained by HMB45 monoclonal antibody. The @entity0 recovered uneventfully, and was doing well three years later without medications. The prior surgical castration may have prevented progression of the disease.

title: [ XXXX (lymphangiomyomatosis) in @entity4 --a case in which clinical course had been modified by previous surgical intervention].

answer: @entity1


abstract: A 42-year-old @entity0 was referred to this institution because of persistent air leak associated with @entity6 . She had undergone a radical hysterectomy with bilateral oophorectomy and left nephrectomy one year previously. The @entity3 was identified as an @entity2 . This, along with the characteristic dermal lesions led to the diagnosis of @entity4 . Preoperative thin-slice chest CT showed multiple thin-walled, round and cystic air spaces in the @entity1 bilaterally, as well as the left pneumothorax. Through a left thoracotomy, suture ligation and laser ablation of the @entity1 was done. Examination of the biopsy specimen of the lung showed hamartoangiomyomatosis with @entity5 . The proliferating smooth muscle in the walls of the bullae was positively stained by HMB45 monoclonal antibody. The @entity0 recovered uneventfully, and was doing well three years later without medications. The prior surgical castration may have prevented progression of the disease.

title: [ @entity1 (lymphangiomyomatosis) in XXXX --a case in which clinical course had been modified by previous surgical intervention].

answer: @entity4


abstract: It has been reported that the two types of muscarinic receptors, "M1" and "M2", exist in the opossum lower esophageal sphincter. The presence of these muscarinic receptor subtypes had been confirmed with the discovery of the M1 selective antagonist, @entity3 . But little is known about muscarinic receptor subtypes in gastric smooth muscle. The aim of this study was to identify the muscarinic receptor subtypes on the gastric smooth muscle responsible for the contraction of @entity0 gastric muscle strip. Also, we examined the mechanism of the action of @entity4 on @entity0 gastric smooth muscle in vitro. The stimulation of M2 receptor caused the contraction of the gastric smooth muscle. @entity2 , selective M1 agonist, caused weak contraction of the gastric smooth muscle, and this response was not affected by the selective M1 antagonist, @entity3 . @entity4 stimulated M2 receptor and caused the gastric smooth muscle contraction. We conclude that the contraction of the gastric smooth muscle is caused by the stimulation of the M2 receptor and this reaction was not affected by @entity1 , suggesting the M2 receptor is located directly on the gastric smooth muscle. The weak contraction of the gastric smooth muscle caused by @entity2 was not affected by the selective M1 antagonist, @entity3 , suggesting that @entity2 may not be a pure M1 selective agonist. The action of @entity4 is supposed to stimulate the M2 receptor.

title: [Studies on the muscarine receptors in XXXX gastric smooth muscle].

answer: @entity0


abstract: In six male @entity0 with @entity3 (a.n.) we describe the anamnestic data, the course of disease and progress in therapy. We also present the results of psychological testing and organic investigations. The mean weight loss at the time of first investigation at the clinic was 70% of ideal body weight. The mean time between first symptoms of a.n. and the first admission at the clinic was 19 months. The psychopathological status showed in all six @entity0 symptoms of obsessive, in two @entity0 additional of @entity1 . This finding is in contradiction to the result in 61 female @entity0 with a.n., where hysteriformic and @entity2 symptoms predominated (36). The follow up time reached from 18 to 84 months (mean 49 months). At the time of last control-investigation we found only one @entity0 restored to health, two @entity0 showed a positive progression. In two @entity0 the @entity1 situation was nearly unchanged, one @entity0 committed suicide. The three @entity0 without positive therapeutic effect were three times respectively six times at the inpatient department and discontinued two times or also three times the psychotherapy. In our experience the course of disease in male @entity0 with a.n. seems to be more serious and more resistant to therapy than in female @entity0 .

title: [ XXXX in male adolescents. I: Clinical findings].

answer: @entity3


abstract: A new cephem cefminox (CMNX, @entity9 ) was used in the treatment of 22 cases of @entity5 without taking into account background factors of @entity0 . The dosage was 2 to 4 g/day in 2 divided doses and the treatment was continued for a period 2 to 17 days. The breakdown of the diseases treated was; @entity1 in 7 cases, secondary lung abscess (rS3)+ @entity11 in 1 case, chronic @entity6 in 3 cases, @entity8 in 10 cases and @entity10 (suspected) in 1 case. The clinical results were rated as excellent in 7 cases, good in 11 cases, fair in 1 case and unknown in 3 cases, with an excellent rate of 36.8% and excellent+good rate of 94.7%. The causative organisms were identified in 10 cases and included @entity2 for 8 cases, @entity7 sp. for 1 case and @entity3 for 1 case. The analysis of bacteriological study revealed disappearance of all of these organisms. However, in 3 out of 8 cases where @entity2 was isolated and in 1 case where @entity7 sp. was isolated the changes of organisms to @entity4 were observed. As the adverse reactions, rashes developed in 1 case and moreover laboratory test results revealed elevation in transaminase in 3 cases. All of these symptoms were mild in nature and none of our cases experienced serious adverse reactions attributable to CMNX. From these results, we believe that CMNX is one of the useful drugs for the treatment of @entity5 .

title: [Clinical study of cefminox in XXXX ].

answer: @entity5


abstract: Acute in vitro histologic studies have shown that the pulsed @entity9 excimer laser causes precise microablation without the surrounding thermal tissue injury associated with frequently used continuous-wave lasers such as the argon, @entity3 , and @entity6 :yttrium aluminum garnet lasers. However, the in vivo healing response of artery wall to excimer laser injury is not known. Accordingly, a @entity9 excimer laser (308 nm, 40 nsec pulse width, 39 mJ/mm2/pulse) was transmitted via a 600 micron fused @entity7 fiber to create 420 craters of varying depths (30 to 270 micron) in 21 normal @entity1 femoral and carotid arteries. At 2 hours, 2 days, 10 days, and 42 days after excimer laser ablation, the artery segments were perfusion fixed in situ and analyzed by light, scanning, and transmission electron microscopy. At 2 hours, craters were covered by a carpet of platelets and entrapped red blood cells. Fibrin and exposed collagen fibers were seen at the crater base. There was a sharp demarcation of the crater-artery wall interface without lateral laser tissue injury. At 2 days, adherent platelets persisted with @entity4 covering the base of the craters. Early healing responses were present, consisting of polymorphonucleated leukocytes and new endothelial cells, which extended over the crater rims. At 10 days, no thrombi were seen, and healing continued with almost complete reendothelialization. Macrophages, fibroblasts, fibrin, and entrapped red blood cells were present below the reendothelialized surface. At 42 days, healing was complete with obliteration of the craters by fibrointimal ingrowth. The surface was completely covered by a smooth monolayer of axially aligned endothelial cells. There were no @entity2 or surface @entity8 responses. These favorable healing responses in normal @entity1 arteries suggest that pulsed lasers with high tissue absorption coefficients, such as the @entity9 excimer laser, may be suitable energy sources for clinical laser angioplasty procedures. However, further studies in @entity5 animals are required before @entity0 clinical responses can be accurately predicted.

title: Early and late healing responses of normal XXXX artery to excimer laser irradiation.

answer: @entity1


abstract: UNASSIGNED: Hematopoietic stem cells (HSCs) depend on the bone marrow (BM) niche for their maintenance, proliferation, and differentiation. The BM niche is composed of nonhematopoietic and mature hematopoietic cells, including megakaryocytes (Mks). @entity1 ( @entity1 ) is a crucial cytokine produced by BM niche cells. However, the cellular source of @entity1 , upon which HSCs primarily depend, is unclear. Moreover, no specific molecular pathway for the regulation of @entity1 production in the BM has been identified. Here, we demonstrate that the membrane protein @entity3 ( @entity3 ) mediates the production of @entity1 and other factors in Mks. @entity0 conditionally deleted for @entity3 in Mks ( @entity3 (Mk  /  )) produced lower levels of @entity1 in Mks. @entity3 -deficient Mks showed down-regulation of @entity3 -related signaling molecules @entity2 , @entity4 , and @entity5 . Knockdown of these molecules in cultured Mks decreased expression of @entity1 . @entity3 (Mk  /  ) @entity0 exhibited reduced BM HSC quiescence and repopulation potential, along with extramedullary hematopoiesis. The low level of @entity1 production may account for the decline in HSC potential in @entity3 (Mk  /  ) @entity0 , as administration of recombinant @entity1 to @entity3 (Mk  /  ) @entity0 restored stem cell potential. Our study identifies @entity3 signaling as a novel molecular mechanism mediating the production of @entity1 and other factors for the maintenance of HSCs.

title: XXXX in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.

answer: @entity3


abstract: Recent anatomoclinical and neuroimaging studies have suggested a possible relation between @entity6 ( @entity6 ) and some @entity2 , such as @entity2 , basal ganglia cavitations and local @entity5 @entity3 . A poor frontocaudal regulation of the left hemisphere and an @entity1 in @entity6 @entity0 have been supposed. To absess these morphofunctional abnormalities, an electrophysiological approach has been performed in 100 consecutive @entity7 @entity0 , screened with various neuropsychological tests and divided in two groups, 50 with @entity6 and 50 with @entity8 ( @entity8 ). @entity0 were submitted to EEG spectral analysis and BAEP studies and comparated with 25 age-matched normal controls. The mean alpha power in occipital regions was significantly higher in @entity6 @entity0 and reduced in @entity8 @entity0 . A significant reduction of the beta activity was recorded in frontal regions in both @entity0 groups as compared to controls. A slight (p < 0.11) increase in I-V interpeak latency (IPL) vs. control group was observed in BAEP from left ear. A significant increase of the same IPL in @entity6 vs. controls (p < 0.025) was observed in BAEP from right ear. A slight n.s. reduction in III wave amplitude in @entity6 @entity0 was observed in BAEP from left ear, whereas a highly significant reduction in the same wave amplitude from BAEP from right ear was observed in @entity6 @entity0 . The above findings cold be account for both a @entity4 with a probable involvement of serotoninergic central pathways, with a significant impairment of pontine segment in @entity8 @entity0 and of mesencephalic region in @entity6 @entity0 .

title: An electrophysiological study in XXXX .

answer: @entity6


abstract: Our longitudinal studies of early postmenopausal @entity0 have shown that there are two characteristic groups. Approximately 35% lose significant amounts of bone mineral (the "fast losers"), whereas approximately 65% lose only a minor amount of bone mineral (the "normal losers"). The rate of @entity2 in postmenopausal @entity0 may be indirectly assessed by use of a number of biochemical markers. New markers have recently been developed, i.e., more specific and robust markers of both bone resorption and formation. The urinary concentration of degradation products of type I collagen and osteocalcin assays that are stable in serum may optimize the procedure to assess the rate of loss. We and others have shown that these markers correlate to the rate of @entity2 with fairly high r values. A prospective 12-year study revealed that the fast bone losers still had significantly higher bone turnover than the normal bone losers. The role of baseline bone mass and rate of loss on @entity1 risk was evaluated. The data showed that a low baseline bone mass (below -1 SD) and a fast rate of loss predisposed to @entity1 to the same extent with an odds ratio of approximately 2. A combination of a low baseline bone mass and a fast rate of loss increased the odds ratio of having a @entity1 . In conclusion, these data suggest that a low bone mass and a fast rate of @entity2 play equal roles for the future risk of @entity1 .

title: The role of XXXX .

answer: @entity2