abstract: We present a case of vaginal @entity2 formation following an initial insult of female genital mutilation (FGM) and crocodile bite to the external genital. A literature review made with regards to acute and late complication of female genital mutilation. Female genital cutting existed as early as the 5th century B.C. This ritualistic practice has affected the physical, mental, and social well being of @entity0 and undermined the basic reproductive and @entity1 of the female population. Worldwide, 85-114 million @entity0 and young @entity0 are subjected to this dreadful practice. It is mostly practiced in Africa and Middle East. Various authors classify female genital cutting differently. The World Health Organization classifies FGM in to FOUR types. Female genital mutilation is associated with immediate, intermediate and long-term complications (1-4). The complications are strongly related to the variant of the mutilation, especially of the third and the fourth types where introcision or vaginal scraping is performed. Vaginal @entity2 formation is a rare phenomenon. Our @entity0 had a total obliteration of the introitus, vaginal @entity3 , which were surgically managed and corrected

title: Vaginal XXXX following severe form of female genital mutilation: a case report.

answer: @entity2


abstract: The aim of our work was to evaluate the diagnostic and treatment of @entity0 with odontogenic @entity1 . METHODS: The last 10 years (1991-2001) 13 males and 4 females, mean age 43 years, with odontogenic @entity1 were submitted to surgical treatment. Primary odontogenic abscess occurred in all. Before admission to our clinic, 14 @entity0 were treated at stomatological department. Diagnosis was made by clinical manifestation, roentgenographical features and confirmed by findings at mediastinum tissues during operation. RESULTS: All @entity0 at the admission day underwent @entity2 with transcervical mediastinal drainage. In 5 cases this management was associated with mediastinal drainage by transthoracic approach. For another 5 @entity0 thoracotomies were performed late, the last 7 survived without thoracotomy. Six @entity0 died, mortality rate was 35.2%. The reason of the high mortality rate-delay of transthoracic mediastinal drainage in 5 cases, when transcervical was inadequate. CONCLUSION: Ample cervicotomy, associated with transcervical and transthoracic mediastinal drainage can significantly reduce the mortality rate for odontogenic @entity1 .

title: [Odontogenic XXXX . Diagnostics and treatment].

answer: @entity1


abstract: BACKGROUND: The aim of the study was to evaluate the possibility of mitral valve surgery in @entity0 with @entity1 and short time outcomes following mitral valve correction combined with coronary artery bypass grafting. METHODS: Thirty one combined coronary artery bypass grafting with mitral valve correction procedures were performed from 1994 to 2002. Mean age was 65.4+/-6 years. 29 pts were in NYHA IV-V functional class. 84% of pts were with impaired left ventricle function. RESULTS: Mitral valve replacement was performed in 16 @entity0 and correction of mitral valve in 15 cases. Mitral valve replacement was performed in cases with significant lesions of the papillary muscles. The mean of 3.05+/-1.8 graft per @entity0 was performed and total coronary revascularisation for 84% of @entity0 . Hospital mortality was 32.2% (10/31). CONCLUSION: In cases of coronary artery bypass grafting for @entity0 with moderate and significant @entity1 after @entity2 , mitral valve correction must be performed.

title: [Myocardial revascularization combined with mitral valve surgery in case of XXXX ].

answer: @entity1


abstract: OBJECTIVE: We aimed to verify the level of blood pressure and @entity4 control and treatment in @entity2 @entity1 seen in Primary Care Centres in Spain. DESIGN: Descriptive study conducted on @entity2 @entity1 @entity0 who attended primary care centres for any reason. LOCATION: Primary Care centres throughout Spain. @entity0 : The study included 6,777 @entity0 . MEASUREMENTS: Blood pressure, weight, height, waist circumference, blood analysis and treatment were recorded RESULTS: The mean age of the sample was 64.40 (11.50) years. Mean blood @entity4 was 141.8 (39) mg/dl, glycosylated haemoglobin was  <=7% in 45.9% of the sample, and blood pressure was under control (BP <=130/80 mmHg) in 9.8% of the @entity0 studied. LDL @entity3 was  <=100mg/dl in 25.3% of the sample. The drugs most used to control @entity1 were; sulphonylureas 2259 @entity0 (33.3%) and @entity5 3768 @entity0 (55.6%). A total of 556 @entity0 were on treatment with insulin, which represented 8.2% of the population studied. The drugs most used for @entity2 were; diuretics in 3395 @entity0 (50.1%) and angiotensin-converting enzyme inhibitors in 4053 @entity0 (59.8%). CONCLUSIONS: A large proportion of @entity2 @entity1 are insufficiently controlled.

title: [Evaluation and control of XXXX @entity1 seen in Primary Care centres in Spain. BRAND II study].

answer: @entity2


abstract: OBJECTIVE: We aimed to verify the level of blood pressure and @entity4 control and treatment in @entity2 @entity1 seen in Primary Care Centres in Spain. DESIGN: Descriptive study conducted on @entity2 @entity1 @entity0 who attended primary care centres for any reason. LOCATION: Primary Care centres throughout Spain. @entity0 : The study included 6,777 @entity0 . MEASUREMENTS: Blood pressure, weight, height, waist circumference, blood analysis and treatment were recorded RESULTS: The mean age of the sample was 64.40 (11.50) years. Mean blood @entity4 was 141.8 (39) mg/dl, glycosylated haemoglobin was  <=7% in 45.9% of the sample, and blood pressure was under control (BP <=130/80 mmHg) in 9.8% of the @entity0 studied. LDL @entity3 was  <=100mg/dl in 25.3% of the sample. The drugs most used to control @entity1 were; sulphonylureas 2259 @entity0 (33.3%) and @entity5 3768 @entity0 (55.6%). A total of 556 @entity0 were on treatment with insulin, which represented 8.2% of the population studied. The drugs most used for @entity2 were; diuretics in 3395 @entity0 (50.1%) and angiotensin-converting enzyme inhibitors in 4053 @entity0 (59.8%). CONCLUSIONS: A large proportion of @entity2 @entity1 are insufficiently controlled.

title: [Evaluation and control of @entity2 XXXX seen in Primary Care centres in Spain. BRAND II study].

answer: @entity1


abstract: OBJECTIVE: To determine mechanisms by which extrinsic innervation to the jejunoileum controls ileal motility. SUMMARY BACKGROUND DATA: Small bowel transplantation is complicated by @entity1 and delayed @entity2 , possibly secondary to altered motility. @entity4 after small bowel transplantation is poorly characterized. METHODS: Motor activity was recorded from four @entity0 during fasting and after feeding small (64 Kcal) or large (256 Kcal) meals. Short-chain @entity5 known to induce unique ileal motor patterns were administered into the distal ileum during fasting. @entity0 were studied before and after jejunoileal denervation simulating autotransplantation. RESULTS: After jejunoileal denervation, the ileal migrating motor complex (MMC) persisted but was no longer temporally coordinated with duodenal MMCs. Spontaneous giant migrating @entity6 occurred more frequently after denervation and more commonly originated proximally in the jejunum, but the velocity of migration did not differ. In contrast, the incidence and characteristics of spontaneous discrete clustered @entity6 (DCCs) did not differ. @entity7 reproducibly initiated giant migrating @entity6 and discrete clustered @entity6 in the distal ileum without differences before and after denervation. Large but not small meals inhibited the ileal MMC after denervation. CONCLUSIONS: Extrinsic innervation and/or intrinsic neural continuity with the duodenum and/or colon control temporal coordination of ileal motility with the duodenum and modulate postprandial inhibition of fasting motility and presence of giant migrating @entity6 . These changes in motility patterns may prove important in mediating @entity3 after small bowel transplantation.

title: XXXX ileal motor activity after a model of jejunoileal autotransplantation.

answer: @entity0


abstract: OBJECTIVE: To assess predictors of sexual function in mid-aged @entity0 . METHODS: We analyzed data of 262 healthy sexually active @entity0 (40-59 years) who filled out the Female Sexual Functioning Index (FSFI), the @entity2 ( @entity2 ) and a general questionnaire containing female/partner data. Correlations between these two measures were also analyzed. RESULTS: Significant inverse correlations were found between all FSFI and @entity2 scores. This was most evident for the @entity2 urogenital score in relation to FSFI total, @entity1 and lubrication scores. Multiple linear regression analysis determined best model predicting total FSFI index scores that explained a 66% of the variance. In this model, @entity2 urogenital score was an important predictor of female sexual function (total FSFI scores) with a significant inverse relation. Additionally total FSFI scores displayed a significant positive correlation with female educational level and HT use and an inverse relation with partner age and female parity. CONCLUSION: Several female/partner factors predicted female sexual function in this mid-aged series. @entity2 urogenital scores significantly correlated with total FSFI scores.

title: Assessing predictors of sexual function in mid-aged sexually active XXXX .

answer: @entity0


abstract: OBJECTIVE: To examine the clinical efficacy and safety of ertapenem, a novel beta-lactam agent with wide activity against common pathogens encountered in @entity3 . SUMMARY BACKGROUND DATA: Ertapenem has a pharmacokinetic profile and antimicrobial spectrum that support the potential for use as a once-a-day agent for the treatment of common mixed aerobic and anaerobic @entity1 . METHODS This prospective, randomized, controlled, and double-blind trial was conducted to compare the safety and efficacy of ertapenem with piperacillin/tazobactam as therapy following adequate surgical management of complicated @entity3 . RESULTS: Six hundred thirty-three @entity0 were included in the modified intent-to-treat population, with 396 meeting all criteria for the evaluable population. @entity0 with a wide range of @entity1 were enrolled; perforated or @entity2 was most common (approximately 60% in microbiologically evaluable population). A prospective, expert panel review was conducted to assess the adequacy of surgical source control in @entity0 who were failures as a component of evaluability. For the modified intent-to-treat groups, 245 of 311 @entity0 treated with ertapenem (79.3%) were cured, as were 232 of 304 (76.2) treated with piperacillin/tazobactam. One hundred seventy-six of 203 microbiologically evaluable @entity0 treated with ertapenem (86.7%) were cured, as were 157 of the 193 (81.2%) treated with piperacillin/tazobactam. CONCLUSIONS: In this study, the efficacy of ertapenem 1 g once a day was equivalent to piperacillin/tazobactam 3.375 g every 6 hours in the treatment of a range of @entity3 . Ertapenem was generally well tolerated and had a similar safety and tolerability profile to piperacillin/tazobactam. A formal process for review of adequacy of source control was found to be of benefit. The results of this trial suggest that ertapenem may be a useful option that could eliminate the need for combination and/or multidosed antibiotic regimens for the empiric treatment of @entity3 .

title: Ertapenem versus piperacillin/tazobactam in the treatment of complicated XXXX : results of a double-blind, randomized comparative phase III trial.

answer: @entity3


abstract: OBJECTIVE: Establishing a new continuity between the right ventricle and the pulmonary artery is the mainstay of repair for persistent truncus arteriosus. We used the @entity7 Viet-Neveux technique without a Lecomte maneuver to construct the connection without a conduit. Here, we retrospectively review the mid-term surgical results to examine the effectiveness of this approach. METHODS: A cylindrical segment incorporating both pulmonary artery branches was sleeve-resected from the truncal artery. The cylindrical segment was cut in the middle and two truncal arterial flaps were combined to form the posterior floor of the new pulmonary arterial trunk. The edge of the floor was attached directly to the superior margin of an oblique incision made in the left-anterior wall of the right ventricle. A @entity4 monocusp was attached to the lower half margin of the right ventricular incision. A large @entity6 -treated pericardial patch was used to form the anterior hood of the new right ventricular outflow tract. Both great arteries were located in a normal spiral configuration. RESULTS: Ten babies (range: 3 days to 9 months of age) underwent this procedure. The Collett-Edwards classification of persistent truncus arteriosus was type I in five cases and type II in five others. There was one @entity0 due to severe @entity3 . During follow-up (36-60 months, median 54 months), only one re-operation was required to enlarge a left @entity5 . Follow-up echocardiography showed @entity1 (mild two, moderate seven, and severe one) and mild flow acceleration in the @entity2 branch and right ventricle-pulmonary artery connection in one case. CONCLUSION: This simple modification for surgical correction of persistent truncus arteriosus may be an effective alternative that overcomes conduit-related problems.

title: Repair of persistent truncus arteriosus without a conduit: sleeve resection of the pulmonary trunk from the aorta and direct right XXXX .

answer: @entity2


abstract: PURPOSE: Breathing motion can create large errors when performing magnetic resonance (MR) thermometry of the breast. Breath holds can be used to minimize these errors, but not eliminate them. Between breath holds, the referenceless method can be used to further reduce errors by relying on regions of nonheated fatty tissue surrounding the heated region. When the surrounding tissue is heated (i.e., for a @entity2 treatment), errors can result due to phase changes of the small amounts of water in the tissue. Therefore, an extension of the referenceless method is proposed which fits for the field in fatty tissue independent of temperature change and extrapolates it to the water-rich regions. METHODS: Nonheating experiments were performed with male volunteers performing breath holds on top of a phantom mimicking a breast with a @entity0 . Heating experiments were also conducted with the same phantom while mechanically simulated breath holds were performed. A nonheating experiment was also performed with a healthy female breast. For each experiment, a nonlinear fitting algorithm was used to fit for temperature change and B0 field inside of the fatty tissue. The field changes were then extrapolated into water-rich ( @entity0 ) portions of the image using a least-squares fit to a fifth-order equation, to correct for field changes due to breath hold changes. Similar results were calculated using the image phase, to mimic the use of the referenceless method. RESULTS: Phantom results showed large reduction of mean error and standard deviation. In the non-heating experiments, the traditional referenceless method and our extended method both corrected by similar amounts. However, in the heating experiments, the average deviation of the temperature calculated with the extended method from a fiber optic probe temperature was approximately 50% less than the deviation with the referenceless method. The in vivo breast results demonstrated @entity1 and mean. CONCLUSIONS: In this paper, we have developed an extension of the referenceless method to correct for breathing errors using multiecho fitting methods to fit for the B0 field in the fatty tissue and using measured field changes as references to extrapolate field corrections into a water-only ( @entity0 ) region. This technique has been validated in a number of situations, and in all cases, the correction method has been shown to greatly reduce temperature error in water-rich regions. The method has also been shown to be an improvement over similar methods that use image phase changes instead of field changes, particularly when temperature changes are induced.

title: Correction of breathing-induced errors in magnetic resonance thermometry of XXXX using multiecho field fitting techniques.

answer: @entity2


abstract: INTRODUCTION: The aim of this systematic review is to assess whether antibacterial agents are more effective than either placebo or no intervention at all in the treatment of acute bacterial @entity1 . @entity0 AND METHODS: We reviewed the databases and search engines: PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Google Scholar to identify randomized clinical trials (RCTs) in children comparing antibiotics versus placebo. @entity1 was considered as the persistence of clinically compatible symptoms for at least 10 days. The methodological quality was assessed using the Jadad scale. Four RCTs were selected. We studied the following variables: cure, clinical improvement (on days 10 to 14), relapse-recurrence (from day 14 to day 60) and presence of adverse effects. The results were combined using meta-analysis. We used the fixed effects model or random model depending on whether or not there was heterogeneity. We estimated the combined relative risk (RR) and 95% confidence interval. RESULTS: Only two RCTs had a Jadad scale score >= 3. Variable cure-improvement (4 RCTs): RR 1.11 (95% CI: 0.9 to 1.3). Variable relapse-recurrence (3 RCTs): RR 0.9 (95% CI: 0.6 to 1.5). Adverse effects (4 RCTs): 2.01 (95% CI 1.1 to 3.8). CONCLUSIONS: In @entity0 with acute @entity1 , antibacterial agents at the studied doses did not appear to provide benefit in terms of cure and improvement, assessed at 10 to 14 days of follow up. Similarly, the percentage of relapse-recurrence was not lower among @entity0 who received antibiotics. Antibiotics are associated more frequently with adverse effects.

title: [The role of antibiotics in acute XXXX : a systematic review and meta-analysis].

answer: @entity1


abstract: A 72-year-old Japanese @entity0 was admitted to our hospital complaining of right upper-quadrant @entity4 , blood in his stool, and symptoms of @entity3 . On physical examination a hard mass, about 6 cm in diameter, was palpable in the right upper quadrant of the abdomen. Computed tomography revealed a @entity6 which had invaded the transverse colon, with liver @entity1 . We diagnosed @entity6 , stage IVB. Colonoscopy was performed for persistent blood in the stools. This revealed an elevated lesion which appeared to be an invasion of @entity6 , with @entity5 from the right-side of the transverse colon. It proved difficult to stop this @entity5 by ordinary therapeutic endoscopy. In order to achieve hemostasis we therefore inserted a covered Ultraflex metallic stent to compress the @entity2 . After stent placement, blood was no longer seen in the @entity0 's stools, he became able to eat soft food and was discharged. This treatment was uninvasive and effective. Covered stent placement appears to be a new and useful method in the management of @entity5 from malignant @entity7 .

title: Covered expandable metallic stent placement for hemostasis of colonic bleeding caused by invasion of XXXX .

answer: @entity6


abstract: BACKGROUND/AIM: @entity4 are among the commonest forms of @entity2 . There are three divisions, namely, @entity3 , soft tissue @entity2 , and @entity2 . Etiologies include motor @entity1 , assaults, falls, and sporting @entity2 . The aim of this study was to determine the profiles including the causes of @entity4 seen in an urban government hospital in the mainland of Penang State, Malaysia. MATERIALS AND METHODS: This was a cross-sectional study that recruited cases reported within a period of 1 year. The source population was @entity4 @entity0 presenting to the Oral and Maxillofacial Surgery Department of an urban hospital in the Penang Mainland, North Malaysia between May 2007 and May 2008. Cases of @entity0 involved in accidents that occurred outside the reference vicinity were excluded. A case report form was developed and completed by the attending clinicians. Data were analyzed using spss version 12.0. RESULTS: A total of 194 cases were studied, with the mean @entity0 age being 27.8 (SD 15.20) years. The majority of @entity0 were Malay @entity0 between 20 and 29 years of age. The main cause of injury was motorcycle accident (53.6%). The commonest injury (in isolation/combination with other @entity2 ) involved the soft tissues (87.2%), dentoalveolar region (33.4%), and facial bones (23.9%). Laceration was the commonest soft tissue injury, and crown @entity3 was the most frequent @entity2 . The facial bone that was most highly involved in the injury was the zygoma. Subjects involved in motorcycle accidents had a significantly higher incidence of sustaining @entity3 . CONCLUSIONS: Motorcycle accidents were the commonest cause of @entity4 in the Penang Mainland, Malaysia. Most @entity0 were young @entity0 . Hence, it is prudent to reinforce appropriate road safety and awareness interventions particularly focusing young male motorcyclists so as to reduce the risk of accidents.

title: Motorcycle accident is the main cause of XXXX in the Penang Mainland, Malaysia.

answer: @entity4


abstract: BACKGROUND: Only a few studies have so far compared the use of different local anesthetic agents in septoplasty procedure with regard to reduction in @entity1 , effectiveness, and related complications. The aim of this study was to compare @entity5 and @entity4 as local anesthetics for septoplasty surgery, in terms of their efficacy and safety. METHODS: Seventy @entity0 randomized into two groups were included in this study. For local anesthesia, 35 @entity0 received @entity5 and 35 received @entity4 . All @entity0 were asked to rate their @entity1 levels on a visual analog scale (VAS) at the 1st, 2nd, 4th, 6th, 8th, 12th, 18th, and 24th postoperative hours. In addition, analgesic consumption of each @entity0 as well as @entity2 was recorded in both groups. RESULTS: VAS scores for @entity1 were significantly lower in the @entity5 group than in the @entity4 group at the 2nd, 6th, 8th, 12th, and 24th postoperative hours (p< 0.05). Comparison of the @entity0 ' usage of analgesics during the first 24 hours postoperatively showed that in the @entity5 group, the percentage of @entity0 that had not used analgesics was 58.5%, and in the @entity4 group the corresponding figure was 41.5%. CONCLUSION: @entity5 is a safe local anesthetic agent with rapid onset of action. When compared with @entity4 , it is associated with improved tissue diffusion, rare @entity2 , and less @entity3 , thus, representing a safe and effective local anesthetic agent for septoplasty procedure.

title: Comparison of local anesthesia with @entity5 and XXXX in septoplasty procedure.

answer: @entity4


abstract: BACKGROUND: Only a few studies have so far compared the use of different local anesthetic agents in septoplasty procedure with regard to reduction in @entity1 , effectiveness, and related complications. The aim of this study was to compare @entity5 and @entity4 as local anesthetics for septoplasty surgery, in terms of their efficacy and safety. METHODS: Seventy @entity0 randomized into two groups were included in this study. For local anesthesia, 35 @entity0 received @entity5 and 35 received @entity4 . All @entity0 were asked to rate their @entity1 levels on a visual analog scale (VAS) at the 1st, 2nd, 4th, 6th, 8th, 12th, 18th, and 24th postoperative hours. In addition, analgesic consumption of each @entity0 as well as @entity2 was recorded in both groups. RESULTS: VAS scores for @entity1 were significantly lower in the @entity5 group than in the @entity4 group at the 2nd, 6th, 8th, 12th, and 24th postoperative hours (p< 0.05). Comparison of the @entity0 ' usage of analgesics during the first 24 hours postoperatively showed that in the @entity5 group, the percentage of @entity0 that had not used analgesics was 58.5%, and in the @entity4 group the corresponding figure was 41.5%. CONCLUSION: @entity5 is a safe local anesthetic agent with rapid onset of action. When compared with @entity4 , it is associated with improved tissue diffusion, rare @entity2 , and less @entity3 , thus, representing a safe and effective local anesthetic agent for septoplasty procedure.

title: Comparison of local anesthesia with XXXX and @entity4 in septoplasty procedure.

answer: @entity5


abstract: PURPOSE: To evaluate the effect of single-dose intravitreal bevacizumab followed by panretinal and macular grid laser, early in the course of central @entity4 (CRVO). METHODS: It is a prospective, non-randomized, interventional study of nine eyes of nine @entity0 with <10 days origin of CRVO who received 2.5 mg (0.1 ml) intravitreal bevacizumab, followed 3 weeks later by panretinal and macular grid photocoagulation. Its effect on visual acuity and anatomical features of CRVO were studied. RESULTS: Nine eyes of nine @entity0 (male : female = 8 : 1, mean age 54 years), with <10 days (average 2.67 days) onset of CRVO, received intravitreal bevacizumab within 7 days of presentation (average 3.1 days) followed 3 weeks later by panretinal with macular grid laser. Presenting mean baseline visual acuity was 20/320 (1.2 logarithm of the minimum angle of resolution (LOGMAR) units). All the @entity0 showed rapid improvement in the form of rapid clearance of @entity5 , decreased @entity1 and @entity2 , and tortuosity. Mean final visual acuity was 20/63 (0.5 LOGMAR units). No @entity0 showed conversion from non-ischemic to ischaemic CRVO, recurrence of @entity3 , and disc collateral formation. CONCLUSION: Early intravitreal bevacizumab followed by panretinal and macular grid laser may provide visually and anatomically favourable results in a case of CRVO. It may also obviate the need for repeated injection. It requires a large randomized study to substantiate the results.

title: Long-term effect of early intervention with single intravitreal injection of bevacizumab followed by panretinal and macular grid photocoagulation in central @entity4 (CRVO) with XXXX : a pilot study.

answer: @entity3


abstract: PURPOSE: To evaluate the effect of single-dose intravitreal bevacizumab followed by panretinal and macular grid laser, early in the course of central @entity4 (CRVO). METHODS: It is a prospective, non-randomized, interventional study of nine eyes of nine @entity0 with <10 days origin of CRVO who received 2.5 mg (0.1 ml) intravitreal bevacizumab, followed 3 weeks later by panretinal and macular grid photocoagulation. Its effect on visual acuity and anatomical features of CRVO were studied. RESULTS: Nine eyes of nine @entity0 (male : female = 8 : 1, mean age 54 years), with <10 days (average 2.67 days) onset of CRVO, received intravitreal bevacizumab within 7 days of presentation (average 3.1 days) followed 3 weeks later by panretinal with macular grid laser. Presenting mean baseline visual acuity was 20/320 (1.2 logarithm of the minimum angle of resolution (LOGMAR) units). All the @entity0 showed rapid improvement in the form of rapid clearance of @entity5 , decreased @entity1 and @entity2 , and tortuosity. Mean final visual acuity was 20/63 (0.5 LOGMAR units). No @entity0 showed conversion from non-ischemic to ischaemic CRVO, recurrence of @entity3 , and disc collateral formation. CONCLUSION: Early intravitreal bevacizumab followed by panretinal and macular grid laser may provide visually and anatomically favourable results in a case of CRVO. It may also obviate the need for repeated injection. It requires a large randomized study to substantiate the results.

title: Long-term effect of early intervention with single intravitreal injection of bevacizumab followed by panretinal and macular grid photocoagulation in central XXXX (CRVO) with @entity3 : a pilot study.

answer: @entity4


abstract: BACKGROUND: @entity1 ( @entity1 ) refractory to medical and surgical therapy is a challenging entity to treat. Topical antibiotics and anti-inflammatory drugs have been increasingly used in managing this disorder. The aim of this pilot study is to evaluate the role of @entity2 ( @entity2 ) in selectively irrigating paranasal sinuses with topical antibiotics with anti-inflammatory in treating recalcitrant @entity1 . A prospective clinical trial was performed at a tertiary referral center. METHODS: Thirteen @entity0 with failed maximal medical and surgical therapies for chronic @entity3 were enrolled in the study. Endoscopic scores as well as the Sino-Nasal Outcome Test 16 (SNOT-16) scores were obtained before and 3, 8, and 16 weeks after maxillary sinus intubation with @entity2 . All @entity0 received topical antibiotics with anti-inflammatory medication for 21 days. RESULTS: Statistically significant reductions in SNOT-16 and endoscopic scores were found before and after topical irrigations. Both scores continued to improve at the 8th and 16th weeks. CONCLUSION: Selective irrigation of maxillary sinuses using @entity2 is a viable alternative in treating recalcitrant @entity1 .

title: Selective irrigation of paranasal sinuses in the treatment of recalcitrant chronic XXXX .

answer: @entity3


abstract: Isolated @entity0 neural lobes were stimulated electrically and the release of @entity2 and @entity1 was measured by radioimmunoassay. The neurohypophyses were stimulated with pulses given at a constant frequency or with a pulse pattern imitating the electrical activity, recorded in vivo, of @entity2 - or @entity1 -containing magnocellular neurones. A single burst recorded from a ' @entity2 ' cell with an intraburst mean frequency of 13 Hz evoked more @entity2 release than the same number of stimuli delivered at a constant frequency of 13 Hz. The amount of @entity2 release per pulse was much higher at the beginning than at the end of the burst. Series of bursts given with interburst silent periods released more hormone than bursts delivered without silent periods. The amount of hormone released by four ' @entity2 ' bursts was significantly larger with silent periods of 21 s than with shorter intervals. Four pulses were much more effective in promoting hormone release when given with 60 ms interspike intervals at the beginning of each second than when delivered at a constant frequency of 4 Hz. Prolonged stimulation with ' @entity2 ' bursts had a greater effect in inducing hormone release than the same number of pulses given in burst delivered at a constant frequency of 13 Hz. After an initial increase the rate of @entity2 release declined rapidly whereas @entity1 release remained elevated for the first 20 min and only then decreased. The release of both @entity2 and @entity1 remained, however, above the release from unstimulated neurohypophyses. 45Ca uptake in the neural lobe was larger when the neurohypophyses were stimulated with @entity2 or @entity1 bursts delivered with silent intervals than when the silent periods were omitted, or when the tissue was stimulated with bursts with the same number of pulses but given at a constant frequency of 13 Hz. In conclusion, it is suggested that the interspike intervals in a burst and the silent intervals between bursts are two important determinants of the effectiveness of the burst pattern in promoting neuropeptide release.

title: The role of patterned burst and interburst interval on the excitation-coupling mechanism in the isolated XXXX neural lobe.

answer: @entity0


abstract: Social functioning (SF) is the ultimate target aimed in treatment plans in @entity1 , thus it is critical to know what are the factors that determine SF. Gender is a well-established variable influencing SF, yet it is not known how social variables and symptoms interact in @entity1 @entity0 . Furthermore, it remains unclear whether the interaction between social variables and symptoms is different in @entity0 compared to @entity0 . Our aim is to test whether social variables are better predictors of SF in community-dwelled individuals with @entity1 , and whether @entity0 and @entity0 differ in how symptoms and social variables interact to impact SF. @entity2 individuals with @entity1 (N = 231) were randomly selected from a register. @entity0 were assessed with symptom measures (PANSS), performance-based social scale (LSP), objective social and demographic variables. Stratification by gender and stepwise multivariate regression analyses by gender were used to find the best-fitting models that predict SF in both gender. @entity0 had poorer SF than @entity0 in spite of showing similar symptom scores. On stepwise regression analyses, gender was the main variable explaining SF, with a significant contribution by disorganized and excitatory symptoms. Age of onset made a less marked, yet significant, contribution to explain SF. When the sample was stratified by gender, disorganized symptoms and 'Income' variable entered the model and accounted for a 30.8% of the SF variance in @entity0 . On the other hand, positive and disorganized symptoms entered the model and accounted for a 36.1% of the SF variance in @entity0 . @entity2 @entity0 and @entity0 with @entity1 differ in the constellation of variables associated with SF. Symptom scores still account for most of the variance in SF in both genders.

title: Complex interaction between symptoms, social factors, and gender in social functioning in a community-dwelling sample of XXXX .

answer: @entity1


abstract: BACKGROUND: Pityriasis versicolor ( @entity5 ) is a chronic @entity3 caused by @entity2 of the Malassezia spp. genus commensal of the keratinized layers of the skin. Under conditions not yet understood, it becomes pathogenic determining the clinical manifestations of the disease. It is a recurrent @entity1 and persistent @entity4 may remain after treatment, causing social problems to those affected. OBJECTIVE: To describe the clinical and epidemiological features of @entity0 diagnosed with @entity5 treated at a referral center for dermatology (Alfredo da Matta Foundation). METHODS: Case-studies in which cutaneous manifestations and epidemiological characteristics of @entity0 diagnosed with @entity5 treated at Alfredo da Matta Foundation were detailed. RESULTS: One hundred and sixteen @entity0 were included in the study from January to August 2008. Most subjects were male, of mixed ethnicity and young age. Most were students who were predisposed to the development of macules. The majority had extensive injuries and past history of the disease. CONCLUSION: The results revealed a high proportion of individuals with extensive clinical manifestations and duration of the disease.

title: Clinical aspects of XXXX with pityriasis versicolor seen at a referral center for tropical dermatology in Manaus, Amazonas, Brazil.

answer: @entity0


abstract: OBJECTIVE: The value of transthoracic sonography in @entity1 is not established. This prospective study was conducted to analyze pleural and parenchymal alterations in @entity0 with @entity1 by transthoracic sonography and to compare the results with the findings of a control group. METHODS: Fifty-three @entity0 with @entity1 and 35 control subjects underwent transthoracic sonography for assessment of (1) basal @entity2 , (2) the presence and number of comet tail artifacts, (3) thickening, (4) an irregular, fragmented pleural line, and (5) @entity3 . RESULTS: Basal @entity2 was revealed in 37.7% of the @entity0 with @entity1 (0% of the control subjects; P < .001), and 98.1% had multiple (>6 per scan) comet tail artifacts (14.3% of the control subjects; P < .001). Only a few artifacts (< or = 6 per scan; P < .001) were shown in 85.7% of the control subjects. All the control subjects had strongly localized comet tail artifacts and no thickened pleural line (84.9% of @entity0 ; P < .001). In 98.1 % of the @entity0 , an irregular, fragmented pleural surface could be detected (82.8% of the control subjects; P < .05). Subpleural alterations were found in 37.7% of the @entity0 and in 8.6% of the control subjects (P < .001). CONCLUSIONS: @entity1 should be considered if multiple comet tail artifacts distributed over the whole surface of the lung together with a thickened and irregular, fragmented pleural line are visible. Transthoracic sonography may reflect the distribution of pleural involvement and may show @entity3 .

title: Transthoracic sonography of XXXX : the role of comet tail artifacts.

answer: @entity1


abstract: OBJECTIVE: To analyze the complications of diagnostic and therapeutic sonographically guided interventional procedures of focal @entity4 observed during a 22-year period in a single center. METHODS: Complications of sonographically guided diagnostic and therapeutic procedures on focal @entity4 , observed during a 22-year period in a single center, were reviewed. From 1979 to 2001, 13,222 @entity0 (age range, 7-89 years; mean, 59 years; 8,688 male and 4,534 female) with 13,777 focal @entity4 underwent 16,648 sonographically guided biopsies and 3,035 therapeutic procedures: pyogenic and amebic abscess aspiration, @entity7 injection of hydatid liver cysts, and percutaneous ablative treatments ( @entity7 injection in either multiple or one-shot sessions, radio frequency ablation, and interstitial laser photocoagulation) of primary and secondary @entity1 . RESULTS: The overall mortality was 0.06%. No @entity2 or major complication occurred after diagnostic procedures and @entity10 . In the therapeutic group mortality was 0.6%: 1 @entity0 died of anaphylactic shock during treatment of a hydatid cyst; 7 @entity0 died after @entity1 ablation with @entity7 injection (6 after one-shot treatments and 1 after multisession treatments). Major complications after @entity1 ablative procedures included 10 cases of @entity6 , 2 cases of @entity9 , 2 cases of self-limiting hemoperitoneum, 2 cases of paralytic ileum, 2 abscesses, and 1 case of @entity3 . One case of a @entity8 and 1 case of intracystic @entity5 occurred after treatment of hydatid liver cysts. CONCLUSIONS: Sonographically guided diagnostic biopsy of focal @entity4 and @entity10 are safe procedures. In contrast, @entity1 ablation procedures have a low but definite risk of mortality and major complications. Puncture of hydatid cysts must be performed only in institutions that can treat anaphylactic shock.

title: Complications after interventional sonography of focal XXXX : a 22-year single-center experience.

answer: @entity4


abstract: @entity1 has been classified as a @entity1 . The presence of glomerular pathologic findings attributable to @entity7 has been observed in only a few @entity0 and therefore has been considered an unusual finding. In the current study, @entity3 deposition within glomeruli was investigated in 2 @entity0 with extreme elevations in serum @entity3 levels and @entity1 . The study material consisted of a renal biopsy specimen from a 31-year-old @entity0 ( @entity0 1) who had @entity8 and a serum @entity3 level of 20.2 mg/dL (5.0 mmol/L) and autopsy kidney specimens from a 19-year-old @entity0 ( @entity0 2) who was being evaluated for @entity2 and a @entity3 level of 18.4 mg/dL (4.6 mmol/L). The renal biopsy specimen for @entity0 1 exhibited @entity3 deposits present in the glomerular capillary basement membranes, where they were associated with @entity5 (21% of glomeruli). Nine percent of the cortical tubules contained calcifications. In @entity0 2, @entity3 was found in the mesangial areas in 95% of glomeruli, filling the Bowman space in 7% of glomeruli, or associated with capillary basement membranes and @entity5 (12% of glomeruli). Fifteen percent of cortical tubules, 4% of outer medullary tubules, and 40% of inner medullary tubules were calcified. In neither case was there immunofluorescence or electron microscopic evidence of primary @entity1 . Thus, glomerular calcification may exceed that occurring in the cortical and outer medullary tubules and may play a significant role in the loss of renal function in @entity1 . @entity1 may also be recognized as an additional cause of @entity9 and @entity6 range @entity4 in @entity0 with extremely high levels of serum @entity3 .

title: XXXX in @entity1 .

answer: @entity1


abstract: @entity1 has been classified as a @entity1 . The presence of glomerular pathologic findings attributable to @entity7 has been observed in only a few @entity0 and therefore has been considered an unusual finding. In the current study, @entity3 deposition within glomeruli was investigated in 2 @entity0 with extreme elevations in serum @entity3 levels and @entity1 . The study material consisted of a renal biopsy specimen from a 31-year-old @entity0 ( @entity0 1) who had @entity8 and a serum @entity3 level of 20.2 mg/dL (5.0 mmol/L) and autopsy kidney specimens from a 19-year-old @entity0 ( @entity0 2) who was being evaluated for @entity2 and a @entity3 level of 18.4 mg/dL (4.6 mmol/L). The renal biopsy specimen for @entity0 1 exhibited @entity3 deposits present in the glomerular capillary basement membranes, where they were associated with @entity5 (21% of glomeruli). Nine percent of the cortical tubules contained calcifications. In @entity0 2, @entity3 was found in the mesangial areas in 95% of glomeruli, filling the Bowman space in 7% of glomeruli, or associated with capillary basement membranes and @entity5 (12% of glomeruli). Fifteen percent of cortical tubules, 4% of outer medullary tubules, and 40% of inner medullary tubules were calcified. In neither case was there immunofluorescence or electron microscopic evidence of primary @entity1 . Thus, glomerular calcification may exceed that occurring in the cortical and outer medullary tubules and may play a significant role in the loss of renal function in @entity1 . @entity1 may also be recognized as an additional cause of @entity9 and @entity6 range @entity4 in @entity0 with extremely high levels of serum @entity3 .

title: @entity1 in XXXX .

answer: @entity1


abstract: Sixty male and female @entity0 , scheduled for colonoscopy were premedicated with glycopyrrolate 0.4 mg intramuscularly. Anaesthesia was induced with 2 mg/kg @entity2 ('Diprivan') and maintained with a continuous infusion of @entity2 at a rate of 3, 6 or 9 mg/kg/h randomly allocated. @entity0 lost consciousness within 60.6 +/- 18.7 (s.d.) s. Preservation of the hypnotic effect was infusion-rate dependent as 15, 40 and 85% of the @entity0 were unconscious on infusion rates of 3, 6 or 9 mg/kg/h @entity2 , respectively. A high degree of sedation was observed in the remaining @entity0 with an incidence of 40, 35 and 0% in the different series. Sedation was light in the remainder of the @entity0 . To increase the acceptability of the procedure, a supplemental bolus of @entity2 and/or an increase in the infusion rate were required in 40, 15 and 10% of the 3, 6 and 9 mg/kg/h infusion rate groups, respectively. The incidence of @entity3 was similar in all three groups (80, 90 and 95%, respectively). Recovery was significantly longer with increasing infusion rate, but remained rapid. The longest time was 7.3 +/- 4.0 min to open eyes on command and 10.6 +/- 4.6 min to answer correctly. The most important side effects were @entity1 on injection (50%) and some restlessness during maintenance (25%). Blood pressure decreased, but heart rate was unaffected. @entity0 breathed room-air spontaneously. Respiratory rate slowed after induction then increased rapidly above baseline values. The incidence of apnoea was 48% with a mean duration of 51 +/- 22s (s.d.). The technique was evaluated as good or adequate in 95% of the cases. We suggest than an analgesic premedication followed by an average of 6 mg/kg/h @entity2 by infusion might be a simple and convenient method of achieving good conditions for colonoscopy.

title: Infusion of XXXX ('Diprivan') as sedative technique for colonoscopies.

answer: @entity2


abstract: A/J @entity0 immunized with @entity4 coupled to keyhole limpet hemocyanin produce antibodies expressing a cross-reactive idiotype (CRIA). The pretreatment of A/J mice with anti-idiotypic polyclonal or monoclonal antibody directed against the major cross-reactive idiotype (CRIA) borne by @entity4 -specific antibody can lead to idiotypic suppression. In this study, we investigate this idiotypic suppression by using four mAb2 ( @entity5 ) recognizing distinct idiotopes whose expression is related to the presence of particular gene segments of the heavy chain V region. 2D3 expression has been related to the presence of some @entity1 in the @entity6 region of the VH gene segment derived from the germ line VH IdCR11. So far, the latter is the only germ-line gene coding for CRIA+ antibody that has been identified in the A/J genome. E4 and H8 expression has been related to the use of a particular D segment, whereas E3 expression has been attributed to certain combinations of D and @entity2 segments. Therefore, we might expect independent regulation of the expression of those various idiotopes in relation to the mechanism of gene recombination. Indeed, we observed that 2D3-suppressed A/J @entity0 still produce the three other idiotopes, suggesting the recombination of those particular D and J segments with a different VH gene. Such a gene has been identified in the genome of BALB/c @entity0 . A/J @entity0 pretreated with one of the other three mAb2 are generally cosuppressed for the expression of E4, H8, and E3, but they still produce 2D3+ antibody. In this case, the IdCR11 VH germ-line gene is most probably recombined with different D and J segments. Molecular evidence for the existence of such molecules has also been presented in the literature. So our serologic data on idiotopic suppression in the @entity3 system can be compared with recent data provided by molecular genetics.

title: Study of idiotopic suppression induced by anti-cross-reactive idiotype monoclonal antibody in the anti- XXXX antibody response.

answer: @entity4


abstract: OBJECTIVE: The aim of this study was to examine the relationships between intention to lose weight, actual @entity2 , and all-cause mortality among overweight individuals with @entity0 . RESEARCH DESIGN AND METHODS: We performed a prospective analysis among 1,401 overweight @entity0 adults aged > or =35 years sampled in the National Health Interview Survey. The previous year intention to lose weight and weight change were assessed by self-report. Nine-year mortality rates were examined according to intent to lose weight and @entity2 , which were adjusted for age, sex, education, ethnicity, smoking, initial body weight, and @entity3 . RESULTS: Individuals trying to lose weight had a 23% lower mortality rate (hazard rate ratio [HRR] 0.77, 95% CI 0.61-0.99) than those who reported not trying to lose weight. This association was as strong for those who failed to lose weight (0.72, 0.55-0.96) as for those who succeeded in losing weight (0.83, 0.63-1.08). Trying to lose weight was beneficial for overweight (BMI 25-30 kg/m2) individuals (0.62, 0.46-0.83) but not for @entity1 (BMI>30) individuals (1.17, 0.72-1.92). Overall @entity2 , without regard to intent, was associated with an increase of 22% (1.22, 0.99-1.50) in the mortality rate. This increase was largely explained by unintentional @entity2 , which was associated with a 58% (1.58, 1.08-2.31) higher mortality rate. CONCLUSIONS: Overweight @entity0 adults trying to lose weight have a reduced risk of all-cause mortality, independent of whether they lose weight. Actual @entity2 is associated with increased mortality only if the @entity2 is unintentional.

title: Trying to lose weight, losing weight, and 9-year mortality in overweight U.S. adults with XXXX .

answer: @entity0


abstract: This paper reports the incidence and natural history of macroscopic @entity6 in a series of 127 consecutive @entity0 with portal @entity1 of various aetiologies. @entity6 was observed endoscopically in 65 @entity0 (51%) and was of two main types. Twenty eight @entity0 had severe or persistent @entity6 which caused clinically significant @entity5 on 80 occasions and accounted for 25% of the bleeds from all sources. The remainder had mild @entity6 . The presence of @entity6 seemed to be independent of the severity of @entity3 or the degree of rise of wedged hepatic venous pressure and there was no difference in age, sex, or drugs prescribed in @entity0 with or without @entity6 . The mean follow up period and the mean number of sclerotherapy treatments was significantly greater (p less than 0.005) in @entity0 with @entity6 . Full thickness gastric biopsies in seven surgical @entity0 and 11 autopsy specimens showed @entity2 . Endoscopic biopsies in 14 @entity0 showed @entity4 in the mucosal layer which was in excess of the degree of inflammatory infiltrate. @entity6 occurred in @entity0 with portal @entity1 of all common aetiologies and the clinical and pathological evidence supports the contention that it reflects a congested gastric mucosa and should be renamed @entity2 . As injection sclerotherapy improves survival from variceal @entity5 @entity2 may become more common. The response to conventional ('anti-erosive') therapy is poor and measures aimed at reducing the gastric portal pressure may be the only effective means of treating this condition.

title: Gastric lesions in portal @entity1 : inflammatory XXXX or @entity2 ?

answer: @entity6


abstract: This paper reports the incidence and natural history of macroscopic @entity6 in a series of 127 consecutive @entity0 with portal @entity1 of various aetiologies. @entity6 was observed endoscopically in 65 @entity0 (51%) and was of two main types. Twenty eight @entity0 had severe or persistent @entity6 which caused clinically significant @entity5 on 80 occasions and accounted for 25% of the bleeds from all sources. The remainder had mild @entity6 . The presence of @entity6 seemed to be independent of the severity of @entity3 or the degree of rise of wedged hepatic venous pressure and there was no difference in age, sex, or drugs prescribed in @entity0 with or without @entity6 . The mean follow up period and the mean number of sclerotherapy treatments was significantly greater (p less than 0.005) in @entity0 with @entity6 . Full thickness gastric biopsies in seven surgical @entity0 and 11 autopsy specimens showed @entity2 . Endoscopic biopsies in 14 @entity0 showed @entity4 in the mucosal layer which was in excess of the degree of inflammatory infiltrate. @entity6 occurred in @entity0 with portal @entity1 of all common aetiologies and the clinical and pathological evidence supports the contention that it reflects a congested gastric mucosa and should be renamed @entity2 . As injection sclerotherapy improves survival from variceal @entity5 @entity2 may become more common. The response to conventional ('anti-erosive') therapy is poor and measures aimed at reducing the gastric portal pressure may be the only effective means of treating this condition.

title: Gastric lesions in portal XXXX : inflammatory @entity6 or @entity2 ?

answer: @entity1


abstract: This paper reports the incidence and natural history of macroscopic @entity6 in a series of 127 consecutive @entity0 with portal @entity1 of various aetiologies. @entity6 was observed endoscopically in 65 @entity0 (51%) and was of two main types. Twenty eight @entity0 had severe or persistent @entity6 which caused clinically significant @entity5 on 80 occasions and accounted for 25% of the bleeds from all sources. The remainder had mild @entity6 . The presence of @entity6 seemed to be independent of the severity of @entity3 or the degree of rise of wedged hepatic venous pressure and there was no difference in age, sex, or drugs prescribed in @entity0 with or without @entity6 . The mean follow up period and the mean number of sclerotherapy treatments was significantly greater (p less than 0.005) in @entity0 with @entity6 . Full thickness gastric biopsies in seven surgical @entity0 and 11 autopsy specimens showed @entity2 . Endoscopic biopsies in 14 @entity0 showed @entity4 in the mucosal layer which was in excess of the degree of inflammatory infiltrate. @entity6 occurred in @entity0 with portal @entity1 of all common aetiologies and the clinical and pathological evidence supports the contention that it reflects a congested gastric mucosa and should be renamed @entity2 . As injection sclerotherapy improves survival from variceal @entity5 @entity2 may become more common. The response to conventional ('anti-erosive') therapy is poor and measures aimed at reducing the gastric portal pressure may be the only effective means of treating this condition.

title: Gastric lesions in portal @entity1 : inflammatory @entity6 or XXXX ?

answer: @entity2


abstract: OBJECTIVE: Phosphoinositide 3-kinase y (PI3Ky) is a G-protein-coupled receptor-activated lipid kinase mainly expressed in leukocytes and cells of the cardiovascular system. PI3Ky plays an important signaling role in inflammatory processes. Since subclinical @entity1 is a hallmark of @entity4 , @entity0 -related insulin resistance, and pancreatic b-cell failure, we asked whether common genetic variation in the PI3Ky gene ( @entity5 ) contributes to body fat content/distribution, serum adipokine/cytokine concentrations, alterations in plasma lipid profiles, insulin sensitivity, insulin release, and @entity3 homeostasis. STUDY DESIGN: Using a tagging single nucleotide polymorphism (SNP) approach, we analyzed genotype-phenotype associations in 2,068 German subjects genotyped for 10 @entity5 SNPs and characterized by oral @entity3 tolerance tests. In subgroups, data from hyperinsulinaemic-euglycaemic clamps, magnetic resonance spectroscopy of the liver, whole-body magnetic resonance imaging, and intravenous @entity3 tolerance tests were available, and peripheral blood mononuclear cells (PBMCs) were used for gene expression analysis. RESULTS: After appropriate adjustment, none of the @entity5 tagging SNPs was significantly associated with body fat content/distribution, adipokine/cytokine concentrations, insulin sensitivity, insulin secretion, or blood @entity3 concentrations (p>0.0127, all; Bonferroni-corrected a-level: 0.0051). However, six non-linked SNPs displayed at least nominal associations with plasma HDL- @entity2 concentrations, two of them ( @entity8 and @entity9 ) reaching the level of study-wide significance (p = 0.0003 and p = 0.0004, respectively). More precisely, @entity8 and @entity9 influenced @entity6 -, but not @entity7 -, @entity2 . With respect to the SNPs' in vivo functionality, @entity8 was significantly associated with @entity5 mRNA expression in PBMCs. CONCLUSIONS: We could demonstrate that common genetic variation in the @entity5 locus, possibly via altered @entity5 gene expression, determines plasma HDL- @entity2 concentrations. Since @entity6 -, but not @entity7 -, @entity2 is influenced by @entity5 variants, PI3Ky may play a role in HDL clearance rather than in HDL biogenesis. Even though the molecular pathways connecting PI3Ky and HDL metabolism remain to be further elucidated, this finding could add a novel aspect to the pathophysiological role of PI3Ky in atherogenesis.

title: Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL- XXXX without Modification of Metabolic or Inflammatory Markers.

answer: @entity2


abstract: BACKGROUND: @entity10 ( @entity11 ), a kind of @entity8 which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. Recent researches have suggested that @entity11 can carry out cardioprotective effects during @entity1 /reperfusion (I/R). However, there have no reports on whether @entity11 can exert protective effects against @entity2 /R injury through the actions of specific microRNAs (miRs). The purpose of this study was to determine which miRs and target genes @entity11 exerted such function through. METHODS: Expression of various miRs in perfused @entity0 hearts was detected using a gene chip. Target genes were predicted with TargetScan, MiRDB and MiRanda. @entity3 /reoxygenation was used to simulate I/R. Cells were transfected by @entity12 -3p mimic, inhibitor and small interfering RNA of @entity9 (avian erythroblastosis virus E26 (v ets) oncogene homolog 1). @entity12 -3p and @entity9 mRNA were quantified by real-time quantitative polymerase chain reaction. The percentage of apoptotic cells was detected by annexin V- @entity7 / @entity6 dyeing and flow cytometry. The protein expression levels of cleaved caspase-3, @entity4 , @entity5 , and @entity9 were examined by western blot analysis. A luciferase reporter assay was used to verify the combination between @entity12 -3p and the 3'-untranslated region of @entity9 . RESULTS: @entity11 pretreatment reduced @entity12 -3p expression in myocardial tissue, as compared to the I/R group. And @entity11 decreased @entity12 -3p expression and apoptosis caused by I/R. However, overexpression of @entity12 -3p further aggravated the changes caused by I/R and blocked all the effects of @entity11 . Knockdown of @entity12 -3p expression also attenuated apoptosis, while knockdown of @entity9 promoted apoptosis. Further, the luciferase reporter assay showed that @entity12 -3p could inhibit @entity9 expression. CONCLUSION: @entity11 pretreatment conveys anti-apoptotic effects after @entity2 /R injury by decreasing @entity12 -3p and increasing @entity9 expression levels.

title: @entity10 Inhibits @entity1 /Reperfusion-Induced XXXX in @entity0 via Downregulation of microRNA-208b-3p.

answer: @entity2


abstract: BACKGROUND: @entity10 ( @entity11 ), a kind of @entity8 which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. Recent researches have suggested that @entity11 can carry out cardioprotective effects during @entity1 /reperfusion (I/R). However, there have no reports on whether @entity11 can exert protective effects against @entity2 /R injury through the actions of specific microRNAs (miRs). The purpose of this study was to determine which miRs and target genes @entity11 exerted such function through. METHODS: Expression of various miRs in perfused @entity0 hearts was detected using a gene chip. Target genes were predicted with TargetScan, MiRDB and MiRanda. @entity3 /reoxygenation was used to simulate I/R. Cells were transfected by @entity12 -3p mimic, inhibitor and small interfering RNA of @entity9 (avian erythroblastosis virus E26 (v ets) oncogene homolog 1). @entity12 -3p and @entity9 mRNA were quantified by real-time quantitative polymerase chain reaction. The percentage of apoptotic cells was detected by annexin V- @entity7 / @entity6 dyeing and flow cytometry. The protein expression levels of cleaved caspase-3, @entity4 , @entity5 , and @entity9 were examined by western blot analysis. A luciferase reporter assay was used to verify the combination between @entity12 -3p and the 3'-untranslated region of @entity9 . RESULTS: @entity11 pretreatment reduced @entity12 -3p expression in myocardial tissue, as compared to the I/R group. And @entity11 decreased @entity12 -3p expression and apoptosis caused by I/R. However, overexpression of @entity12 -3p further aggravated the changes caused by I/R and blocked all the effects of @entity11 . Knockdown of @entity12 -3p expression also attenuated apoptosis, while knockdown of @entity9 promoted apoptosis. Further, the luciferase reporter assay showed that @entity12 -3p could inhibit @entity9 expression. CONCLUSION: @entity11 pretreatment conveys anti-apoptotic effects after @entity2 /R injury by decreasing @entity12 -3p and increasing @entity9 expression levels.

title: XXXX Inhibits @entity1 /Reperfusion-Induced @entity2 in @entity0 via Downregulation of microRNA-208b-3p.

answer: @entity10


abstract: BACKGROUND: @entity10 ( @entity11 ), a kind of @entity8 which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. Recent researches have suggested that @entity11 can carry out cardioprotective effects during @entity1 /reperfusion (I/R). However, there have no reports on whether @entity11 can exert protective effects against @entity2 /R injury through the actions of specific microRNAs (miRs). The purpose of this study was to determine which miRs and target genes @entity11 exerted such function through. METHODS: Expression of various miRs in perfused @entity0 hearts was detected using a gene chip. Target genes were predicted with TargetScan, MiRDB and MiRanda. @entity3 /reoxygenation was used to simulate I/R. Cells were transfected by @entity12 -3p mimic, inhibitor and small interfering RNA of @entity9 (avian erythroblastosis virus E26 (v ets) oncogene homolog 1). @entity12 -3p and @entity9 mRNA were quantified by real-time quantitative polymerase chain reaction. The percentage of apoptotic cells was detected by annexin V- @entity7 / @entity6 dyeing and flow cytometry. The protein expression levels of cleaved caspase-3, @entity4 , @entity5 , and @entity9 were examined by western blot analysis. A luciferase reporter assay was used to verify the combination between @entity12 -3p and the 3'-untranslated region of @entity9 . RESULTS: @entity11 pretreatment reduced @entity12 -3p expression in myocardial tissue, as compared to the I/R group. And @entity11 decreased @entity12 -3p expression and apoptosis caused by I/R. However, overexpression of @entity12 -3p further aggravated the changes caused by I/R and blocked all the effects of @entity11 . Knockdown of @entity12 -3p expression also attenuated apoptosis, while knockdown of @entity9 promoted apoptosis. Further, the luciferase reporter assay showed that @entity12 -3p could inhibit @entity9 expression. CONCLUSION: @entity11 pretreatment conveys anti-apoptotic effects after @entity2 /R injury by decreasing @entity12 -3p and increasing @entity9 expression levels.

title: @entity10 Inhibits XXXX /Reperfusion-Induced @entity2 in @entity0 via Downregulation of microRNA-208b-3p.

answer: @entity1


abstract: BACKGROUND: @entity10 ( @entity11 ), a kind of @entity8 which is extracted from a variety of diets, has been reported to convey protective effects of various diseases. Recent researches have suggested that @entity11 can carry out cardioprotective effects during @entity1 /reperfusion (I/R). However, there have no reports on whether @entity11 can exert protective effects against @entity2 /R injury through the actions of specific microRNAs (miRs). The purpose of this study was to determine which miRs and target genes @entity11 exerted such function through. METHODS: Expression of various miRs in perfused @entity0 hearts was detected using a gene chip. Target genes were predicted with TargetScan, MiRDB and MiRanda. @entity3 /reoxygenation was used to simulate I/R. Cells were transfected by @entity12 -3p mimic, inhibitor and small interfering RNA of @entity9 (avian erythroblastosis virus E26 (v ets) oncogene homolog 1). @entity12 -3p and @entity9 mRNA were quantified by real-time quantitative polymerase chain reaction. The percentage of apoptotic cells was detected by annexin V- @entity7 / @entity6 dyeing and flow cytometry. The protein expression levels of cleaved caspase-3, @entity4 , @entity5 , and @entity9 were examined by western blot analysis. A luciferase reporter assay was used to verify the combination between @entity12 -3p and the 3'-untranslated region of @entity9 . RESULTS: @entity11 pretreatment reduced @entity12 -3p expression in myocardial tissue, as compared to the I/R group. And @entity11 decreased @entity12 -3p expression and apoptosis caused by I/R. However, overexpression of @entity12 -3p further aggravated the changes caused by I/R and blocked all the effects of @entity11 . Knockdown of @entity12 -3p expression also attenuated apoptosis, while knockdown of @entity9 promoted apoptosis. Further, the luciferase reporter assay showed that @entity12 -3p could inhibit @entity9 expression. CONCLUSION: @entity11 pretreatment conveys anti-apoptotic effects after @entity2 /R injury by decreasing @entity12 -3p and increasing @entity9 expression levels.

title: @entity10 Inhibits @entity1 /Reperfusion-Induced @entity2 in XXXX via Downregulation of microRNA-208b-3p.

answer: @entity0


abstract: OBJECTIVE: The prevalence of @entity1 in Sweden during the " @entity2 period" (1984-1996) was one of the highest in the world. The aim of this study was to assess the @entity1 incidence in our region over the 41-year period, and how diagnostic activity and diagnostic accuracy were affected by the introduction of antibody testing. We also looked into how @entity0 with mild @entity3 were evaluated. METHODS: In the county of   sterg  tland in Sweden, 2790 paediatric @entity0 were investigated for suspected @entity1 between 1973 and 2013. Notes were scrutinised for data on sex, age, histopathological reports and final diagnosis. For comparative purposes this period was divided into three sub-periods (1973-1983, 1984-1996 and 1997-2013) named pre- @entity2 , @entity2 and @entity2 . RESULTS: @entity1 diagnosis was received by 1,030 @entity0 . The peak incidence rate, 301 cases/100,000 in 1994 for the age group 0-1.9 years is the highest figure ever reported. The other age groups, 2-4.9, 5-14.9, and 15-17.9 years, also had high incidence rates. After the 1984-1996 " @entity2 period" the incidence decreased for the youngest group but continued to increase for the other groups. The cumulative incidence at 18 years-of-age for @entity0 born during the @entity2 reached 14 cases/1000 births, the highest figure hitherto reported. Diagnostic activity differed significantly between the three sub-periods (p<0.001) increasing gradually from 1984 and reaching a peak value of 0.87 in 2012. Cases of mild @entity3 were more frequently regarded as @entity1 cases, decreasing significantly in the " @entity2 " period (p<0.001). CONCLUSIONS: The incidence rate and cumulative incidence of @entity1 were possibly the highest ever reported. Changes in diagnostic activity and accuracy could not be attributed to the introduction of new antibody tests, possibly because of other changes e.g. variations in the symptoms at presentation and improved knowledge of the disease among parents and health professionals.

title: Unusually High Incidence of Paediatric XXXX in Sweden during the Period 1973 - 2013.

answer: @entity1


abstract: The chromosome 15q13.3 microdeletion is a pathogenic copy number variation @entity5 , @entity9 , @entity3 , and @entity2 ( @entity2 ). We generated @entity1 carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in @entity0 @entity0 . Here, we report that @entity1 with a heterozygous deletion on a C57BL/6 background (D/+ @entity1 ) demonstrated phenotypes including enlarged/heavier brains ( @entity10 ) with enlarged lateral ventricles, decreased social interactions, increased repetitive grooming behavior, reduced ultrasonic vocalizations, decreased auditory-evoked gamma band EEG, and reduced event-related potentials. D/+ @entity1 had normal body weight, activity levels, sensory gating, and cognitive abilities and no signs of @entity5 / @entity6 . Our results demonstrate that D/+ @entity1 represent @entity2 -related phenotypes associated with 15q13.3 microdeletion syndrome. Further investigations using this chromosome-engineered @entity1 model may uncover the common mechanism(s) underlying @entity2 and other @entity4 representing the 15q13.3 microdeletion syndrome, @entity5 , @entity9 , and @entity3 . SIGNIFICANCE STATEMENT: Recently discovered pathologic copy number variations (CNVs) from @entity0 with @entity4 show very strong penetrance and thus are excellent candidates for @entity1 models of disease that can mirror the @entity0 genetic conditions with high fidelity. A 15q13.3 microdeletion in @entity0 results in a range of @entity4 , @entity5 , @entity9 , @entity3 , and @entity2 ( @entity2 ). The disorders conferred by a 15q13.3 microdeletion also have overlapping genetic architectures and comorbidity in other @entity0 populations such as those with @entity5 and @entity3 / @entity8 , as well as @entity3 and @entity2 . We generated @entity1 carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in @entity0 @entity0 , which allowed us to investigate the potential causes of @entity4 associated with the @entity7 .

title: @entity1 Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to XXXX .

answer: @entity2


abstract: The chromosome 15q13.3 microdeletion is a pathogenic copy number variation @entity5 , @entity9 , @entity3 , and @entity2 ( @entity2 ). We generated @entity1 carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in @entity0 @entity0 . Here, we report that @entity1 with a heterozygous deletion on a C57BL/6 background (D/+ @entity1 ) demonstrated phenotypes including enlarged/heavier brains ( @entity10 ) with enlarged lateral ventricles, decreased social interactions, increased repetitive grooming behavior, reduced ultrasonic vocalizations, decreased auditory-evoked gamma band EEG, and reduced event-related potentials. D/+ @entity1 had normal body weight, activity levels, sensory gating, and cognitive abilities and no signs of @entity5 / @entity6 . Our results demonstrate that D/+ @entity1 represent @entity2 -related phenotypes associated with 15q13.3 microdeletion syndrome. Further investigations using this chromosome-engineered @entity1 model may uncover the common mechanism(s) underlying @entity2 and other @entity4 representing the 15q13.3 microdeletion syndrome, @entity5 , @entity9 , and @entity3 . SIGNIFICANCE STATEMENT: Recently discovered pathologic copy number variations (CNVs) from @entity0 with @entity4 show very strong penetrance and thus are excellent candidates for @entity1 models of disease that can mirror the @entity0 genetic conditions with high fidelity. A 15q13.3 microdeletion in @entity0 results in a range of @entity4 , @entity5 , @entity9 , @entity3 , and @entity2 ( @entity2 ). The disorders conferred by a 15q13.3 microdeletion also have overlapping genetic architectures and comorbidity in other @entity0 populations such as those with @entity5 and @entity3 / @entity8 , as well as @entity3 and @entity2 . We generated @entity1 carrying a deletion of 1.2 Mb homologous to the 15q13.3 microdeletion in @entity0 @entity0 , which allowed us to investigate the potential causes of @entity4 associated with the @entity7 .

title: XXXX Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to @entity2 .

answer: @entity1


abstract: UNASSIGNED: MicroRNA molecules have a variety of roles in cellular development and proliferation processes, including normal osteogenesis. These effects are exerted through post-translational inhibition of target genes. Altered miRNA expression has been demonstrated in several @entity1 , both in the @entity1 tissue and in the peripheral circulation. This may influence @entity2 if the specific miRNA targets are encoded by @entity1 suppressor genes or oncogenes. To date, most research investigating the role of microRNAs and primary @entity7 has focused on @entity3 and @entity5 . Several microRNAs including the @entity9 family have been implicated in @entity2 via effects on the Notch signaling pathway. Progression, invasion, and @entity0 of @entity3 cells is also influenced by microRNA expression. In addition, microRNA expression may affect the response to chemotherapy in @entity3 and thus hold potential for future use as either a prognostic indicator or a therapeutic target. The @entity10 fusion protein produced in @entity5 has been shown to induce changes in miRNA expression. MicroRNA expression profiling may have some potential for prediction of disease progression and survival in @entity5 . There is limited evidence to support a role for microRNAs in other primary @entity7 , either malignant or benign; however, early work is suggestive of involvement in @entity4 , @entity8 , and @entity6 of bone.

title: microRNA and Bone XXXX .

answer: @entity1


abstract: BACKGROUND: We evaluated the side effects of @entity6 (BP) on tooth extraction socket healing in spontaneously @entity0 Torii (SDT) @entity1 , an established model of @entity0 , to develop an animal model of BP-related @entity3 of the jaws (BRONJ). MATERIALS AND METHODS: Male Sprague-Dawley (SD) @entity1 and SDT @entity1 were randomly assigned to the @entity4 ( @entity7 )-treated groups (SD/ @entity7 or SDT/ @entity7 ) or to the control groups (SD/control or SDT/control). @entity1 in the SD/ @entity7 or SDT/ @entity7 groups received an intravenous bolus injection of @entity7 (35  g/kg) every 2 weeks. Each group consisted of 6 @entity1 each. Twenty-one weeks after @entity7 treatment began, the left maxillary molars were extracted. The @entity1 were euthanized at 2, 4, or 8 weeks after tooth extraction, and the total maxillae were harvested for histological and histochemical studies. RESULTS: In the oral cavity, bone exposure persisted at the tooth extraction site in all @entity1 of the SDT/ @entity7 group until 8 weeks after tooth extraction. In contrast, there was no bone exposure in SD/control or SDT/control groups, and only 1 of 6 @entity1 in the SD/ @entity7 group showed bone exposure. Histologically, necrotic bone areas with empty lacunae, microbial colonies, and less invasion by inflammatory cells were observed. The number of @entity5 -resistant acid phosphatase-positive osteoclasts was lower in the SDT/ @entity7 group than in the SD/control group. The mineral apposition rate was significantly lower in the SDT/ @entity7 group compared with the SD/control group. CONCLUSIONS: This study demonstrated the development of BRONJ-like lesions in @entity1 and suggested that @entity2 with less inflammatory cell infiltration plays an important role in the development of BRONJ.

title: Establishment of an Animal Model of XXXX -Related @entity3 of the Jaws in Spontaneously @entity0 Torii @entity1 .

answer: @entity6


abstract: BACKGROUND: We evaluated the side effects of @entity6 (BP) on tooth extraction socket healing in spontaneously @entity0 Torii (SDT) @entity1 , an established model of @entity0 , to develop an animal model of BP-related @entity3 of the jaws (BRONJ). MATERIALS AND METHODS: Male Sprague-Dawley (SD) @entity1 and SDT @entity1 were randomly assigned to the @entity4 ( @entity7 )-treated groups (SD/ @entity7 or SDT/ @entity7 ) or to the control groups (SD/control or SDT/control). @entity1 in the SD/ @entity7 or SDT/ @entity7 groups received an intravenous bolus injection of @entity7 (35  g/kg) every 2 weeks. Each group consisted of 6 @entity1 each. Twenty-one weeks after @entity7 treatment began, the left maxillary molars were extracted. The @entity1 were euthanized at 2, 4, or 8 weeks after tooth extraction, and the total maxillae were harvested for histological and histochemical studies. RESULTS: In the oral cavity, bone exposure persisted at the tooth extraction site in all @entity1 of the SDT/ @entity7 group until 8 weeks after tooth extraction. In contrast, there was no bone exposure in SD/control or SDT/control groups, and only 1 of 6 @entity1 in the SD/ @entity7 group showed bone exposure. Histologically, necrotic bone areas with empty lacunae, microbial colonies, and less invasion by inflammatory cells were observed. The number of @entity5 -resistant acid phosphatase-positive osteoclasts was lower in the SDT/ @entity7 group than in the SD/control group. The mineral apposition rate was significantly lower in the SDT/ @entity7 group compared with the SD/control group. CONCLUSIONS: This study demonstrated the development of BRONJ-like lesions in @entity1 and suggested that @entity2 with less inflammatory cell infiltration plays an important role in the development of BRONJ.

title: Establishment of an Animal Model of @entity6 -Related @entity3 of the Jaws in Spontaneously XXXX Torii @entity1 .

answer: @entity0


abstract: BACKGROUND: We evaluated the side effects of @entity6 (BP) on tooth extraction socket healing in spontaneously @entity0 Torii (SDT) @entity1 , an established model of @entity0 , to develop an animal model of BP-related @entity3 of the jaws (BRONJ). MATERIALS AND METHODS: Male Sprague-Dawley (SD) @entity1 and SDT @entity1 were randomly assigned to the @entity4 ( @entity7 )-treated groups (SD/ @entity7 or SDT/ @entity7 ) or to the control groups (SD/control or SDT/control). @entity1 in the SD/ @entity7 or SDT/ @entity7 groups received an intravenous bolus injection of @entity7 (35  g/kg) every 2 weeks. Each group consisted of 6 @entity1 each. Twenty-one weeks after @entity7 treatment began, the left maxillary molars were extracted. The @entity1 were euthanized at 2, 4, or 8 weeks after tooth extraction, and the total maxillae were harvested for histological and histochemical studies. RESULTS: In the oral cavity, bone exposure persisted at the tooth extraction site in all @entity1 of the SDT/ @entity7 group until 8 weeks after tooth extraction. In contrast, there was no bone exposure in SD/control or SDT/control groups, and only 1 of 6 @entity1 in the SD/ @entity7 group showed bone exposure. Histologically, necrotic bone areas with empty lacunae, microbial colonies, and less invasion by inflammatory cells were observed. The number of @entity5 -resistant acid phosphatase-positive osteoclasts was lower in the SDT/ @entity7 group than in the SD/control group. The mineral apposition rate was significantly lower in the SDT/ @entity7 group compared with the SD/control group. CONCLUSIONS: This study demonstrated the development of BRONJ-like lesions in @entity1 and suggested that @entity2 with less inflammatory cell infiltration plays an important role in the development of BRONJ.

title: Establishment of an Animal Model of @entity6 -Related XXXX of the Jaws in Spontaneously @entity0 Torii @entity1 .

answer: @entity3


abstract: BACKGROUND: We evaluated the side effects of @entity6 (BP) on tooth extraction socket healing in spontaneously @entity0 Torii (SDT) @entity1 , an established model of @entity0 , to develop an animal model of BP-related @entity3 of the jaws (BRONJ). MATERIALS AND METHODS: Male Sprague-Dawley (SD) @entity1 and SDT @entity1 were randomly assigned to the @entity4 ( @entity7 )-treated groups (SD/ @entity7 or SDT/ @entity7 ) or to the control groups (SD/control or SDT/control). @entity1 in the SD/ @entity7 or SDT/ @entity7 groups received an intravenous bolus injection of @entity7 (35  g/kg) every 2 weeks. Each group consisted of 6 @entity1 each. Twenty-one weeks after @entity7 treatment began, the left maxillary molars were extracted. The @entity1 were euthanized at 2, 4, or 8 weeks after tooth extraction, and the total maxillae were harvested for histological and histochemical studies. RESULTS: In the oral cavity, bone exposure persisted at the tooth extraction site in all @entity1 of the SDT/ @entity7 group until 8 weeks after tooth extraction. In contrast, there was no bone exposure in SD/control or SDT/control groups, and only 1 of 6 @entity1 in the SD/ @entity7 group showed bone exposure. Histologically, necrotic bone areas with empty lacunae, microbial colonies, and less invasion by inflammatory cells were observed. The number of @entity5 -resistant acid phosphatase-positive osteoclasts was lower in the SDT/ @entity7 group than in the SD/control group. The mineral apposition rate was significantly lower in the SDT/ @entity7 group compared with the SD/control group. CONCLUSIONS: This study demonstrated the development of BRONJ-like lesions in @entity1 and suggested that @entity2 with less inflammatory cell infiltration plays an important role in the development of BRONJ.

title: Establishment of an Animal Model of @entity6 -Related @entity3 of the Jaws in Spontaneously @entity0 Torii XXXX .

answer: @entity1


abstract: OBJECTIVE: Considerable controversy surrounds whether a history of @entity2 media with effusion (OME) in early childhood causes later speech and @entity3 . We conducted a meta-analysis of prospective studies to determine: 1) whether a history of OME in early childhood is related to receptive language, expressive language, vocabulary, syntax, or speech development in @entity0 1 to 5 years old and 2) whether @entity1 caused by @entity2 media in early childhood is related to @entity0 's receptive language or expressive language through 2 years of age. METHODS: We searched online databases and bibliographies of OME studies and reviews for prospective or randomized clinical trials published between January 1966 and October 2002 that examined the relationship of OME or OME-associated @entity1 in early childhood to @entity0 's later speech and language development. The original search identified 38 studies, of which 14 had data suitable for calculating a pooled correlation coefficient (correlational studies) or standard difference between parallel groups (group studies). Random-effects meta-analysis was used to pool data when at least 3 studies had usable data for a particular outcome. RESULTS: We performed 11 meta-analyses. There were no significant findings for the analyses of OME during early childhood versus receptive or expressive language during the preschool years in the correlation studies. Similarly, there were no significant findings for OME versus vocabulary, syntax, or speech during the preschool years. Conversely, there was a significant negative association between OME and preschoolers' receptive and expressive language (lower language) (0.24 and 0.25 standard difference, respectively) in the group studies. Additionally, hearing was also related to receptive and expressive language in infancy (3%-9% of variance). CONCLUSIONS: Our results indicate no to very small negative associations of OME and associated @entity1 to @entity0 's later speech and language development. These findings may overestimate the impact of OME on outcomes, because most studies did not adjust for known confounding variables (such as socioeconomic status) and excluded data not suitable for statistical pooling, especially from methodologically sound studies. Although some OME language differences were detectable by meta-analysis due to increased statistical power, the clinical relevance for otherwise healthy @entity0 is uncertain.

title: XXXX media and speech and language: a meta-analysis of prospective studies.

answer: @entity2


abstract: PURPOSE: Central nervous system manifestations are rare clinical features of @entity10 , and occur in 4-8% of the @entity0 , but few studies were dedicated to them. METHODS: This retrospective study (1988-2001) include 14 consecutive @entity0 suffering from @entity10 . Involvement of central nervous system was defined as follows: suggestive neurological signs, compatible cerebral imaging, efficacy of the specific treatment of the @entity10 . RESULTS: Four @entity0 had a central nervous system manifestation (29%), including three @entity0 (average age 51 years). The signs were inaugural in a case. The manifestations were the following: sensibility disturbance (three cases), @entity4 (two cases), @entity9 (one case), and @entity7 (two cases). Cranial nerves were constantly involved. Cerebral magnetic resonance imaging findings were: @entity5 and @entity1 (one case), @entity8 (two cases). Under @entity3 therapy associated with @entity6 , in spite of a recurrence at 27 months in one @entity0 , all @entity0 had a complete remission. There was no death, with a median follow-up of 66 months. Except the ocular signs, that were more common (three cases), these @entity0 had the usual characteristics of the @entity10 : rhinosinusitis (four cases), pulmonary (three cases), renal (three cases), and peripheral nervous system involvement (three cases). CONCLUSIONS: Our study, based on precise criteria, indicates that the frequency of the central neurologic manifestations of @entity10 is probably under estimated. Cranial nerves involvement is highly evocative. The long-term prognosis seems good, in spite of the associated @entity2 .

title: [Incidence and presentation of the central neurological manifestations of XXXX : a monocentric study of 14 cases].

answer: @entity10


abstract: @entity1 is the most common @entity1 in @entity0 aged 15-34. Although post-treatment prognosis is generally very good, the impact on sexuality, gender identity and fertility is amplified in this age group. A Canadian study of @entity0 with @entity1 explores how @entity0 (re)consider questions of sexuality and gender post diagnosis and treatment. Semi-structured interviews with 40 @entity0 were analyzed using thematic decomposition, an analytic technique that combines discursive approaches with thematic analysis. The theoretical framework that guides this work relies on material discursive approaches. From an analytic stance, this perspective is concerned with a focus on the ways in which both subjectivity and the body are experienced and constituted in language. In particular, we are concerned with how these @entity0 interpret the (altered) male body as a locus of gender signification and gender disruption. @entity0 in this study construct @entity1 as alternately inhibiting and enhancing masculinity and sexuality. Disruption interpolates with potentiality. A discourse of precarious masculinity predominates these accounts, wherein the link between anatomy and masculinity is simultaneously asserted and disavowed. Constructions of anatomical essentialism (i.e., testicular integrity is equated with masculinity) are juxtaposed against construals of anatomical superfluousness (i.e., other sites of sexuality and male identity are emphasized as being more central).

title: (Dis)embodying gender and sexuality in XXXX .

answer: @entity1


abstract: OBJECTIVE: To identify fetal heart rate characteristics of @entity0 with uterine @entity1 compared with successful vaginal birth after cesarean (VBAC) controls. METHODS: This is a case-control study. Obstetric records of @entity0 at the University of Washington Medical Center and Swedish Medical Center were reviewed for cases of uterine @entity1 . Entry criteria included operative confirmation of the diagnosis, gestational age beyond 24 weeks, presence of one or more prior low transverse uterine incisions, and availability of fetal heart tracings. Each case was matched with 3 controls randomly selected from a pool of successful VBAC deliveries at the same institution within 1 year. Three blinded independent examiners then examined fetal heart tracings. Each tracing was rated for the presence of fetal @entity2 , mild or moderate variable decelerations, severe variable decelerations, late decelerations, prolonged decelerations, fetal @entity3 , and loss of uterine tone in both the first and second stages of labor separately. RESULTS: Of the 48 uterine ruptures identified, 36 met inclusion criteria. These were matched with 100 controls. Cases showed significantly increased rates of fetal @entity3 than controls in the first stage (P <.01) and second stage (P <.01). No significant differences were noted in rates of mild or severe variable decelerations, late decelerations, prolonged decelerations, fetal @entity2 , or loss of uterine tone. CONCLUSION: Fetal @entity3 in the first and second stage is the only finding to differentiate uterine ruptures from successful VBAC @entity0 . LEVEL OF EVIDENCE: II-2

title: Fetal heart rate changes associated with uterine XXXX .

answer: @entity1


abstract: UNASSIGNED: From the available literature, it is unclear what proportion of pancreatic @entity3 express @entity1 receptors ( @entity9 , @entity8 ), @entity7 receptors (PR), and @entity2 receptors (AR), and if any of these markers have prognostic significance. We aimed to assess (1) the expression and (2) the correlation of the aforementioned markers with clinicopathological parameters and prognosis in @entity0 with @entity5 . During a five-year period, 60 @entity0 with @entity6 underwent surgical resection at a single institution. Immunohistochemical stains of the studied markers were quantified by Image analysis system. @entity9 expression was positively associated with PR expression. Moreover, @entity8 was inversely associated with the presence of metastases, whereas no significant associations implicated AR. As far as the prognostic significance of the studied receptors is concerned, higher @entity9 expression correlated with poorer survival at the univariate analysis, but the finding dissipated at the multivariate approach. No significant associations with overall survival were noted regarding the other receptors. The role of sex hormone receptors in the survival from @entity5 seems rather limited. Further prospective studies assessing those receptors should ideally be designed in order to confirm our results and possibly outline additional correlations between other @entity4 receptors and features of @entity5 .

title: Prognostic role of sex @entity4 receptors in XXXX .

answer: @entity5


abstract: UNASSIGNED: From the available literature, it is unclear what proportion of pancreatic @entity3 express @entity1 receptors ( @entity9 , @entity8 ), @entity7 receptors (PR), and @entity2 receptors (AR), and if any of these markers have prognostic significance. We aimed to assess (1) the expression and (2) the correlation of the aforementioned markers with clinicopathological parameters and prognosis in @entity0 with @entity5 . During a five-year period, 60 @entity0 with @entity6 underwent surgical resection at a single institution. Immunohistochemical stains of the studied markers were quantified by Image analysis system. @entity9 expression was positively associated with PR expression. Moreover, @entity8 was inversely associated with the presence of metastases, whereas no significant associations implicated AR. As far as the prognostic significance of the studied receptors is concerned, higher @entity9 expression correlated with poorer survival at the univariate analysis, but the finding dissipated at the multivariate approach. No significant associations with overall survival were noted regarding the other receptors. The role of sex hormone receptors in the survival from @entity5 seems rather limited. Further prospective studies assessing those receptors should ideally be designed in order to confirm our results and possibly outline additional correlations between other @entity4 receptors and features of @entity5 .

title: Prognostic role of sex XXXX receptors in @entity5 .

answer: @entity4


abstract: The goal of this study was to examine the effect of insulin-like growth factor I ( @entity2 ; added during post-thaw culture (48 h)) on the preimplantation viability and quality of cryopreserved @entity0 in vivo recovered embryos. The morula stage embryos, non-surgically recovered from superovulated dairy @entity0 of Czech Fleckvieh @entity0 breed, had previously been cryopreserved by a slow freezing technique and stored in liquid @entity1 since 1989-1990. Following thawing, the embryos were cultured for 48 h either alone (no @entity2 ) or in the presence of @entity2 (10 or 100 ng/ml); non-cultured embryos served as a control. Thereafter, the embryos were analyzed for cleavage to the blastocyst stage, apoptosis (TUNEL), embryo cell number and quality of actin cytoskeleton. Following post-thaw culture 41% of embryos developed to advanced blastocysts. @entity2 increased this per cent and, at a higher dose, essentially reduced the per cent of degenerated embryos. In cultured embryos, @entity2 at both doses elevated the cell number compared with non-cultured embryos. However, in comparison with embryos cultured without @entity2 , only the higher @entity2 dose resulted in elevating the embryo cell number. The TUNEL index was significantly lowered by @entity2 treatment. Thawed embryos were mostly of the grade III actin type and fewer (12%) had grade II actin, whilst no grade I actin embryos were noted. The addition of @entity2 resulted in the appearance of grade I actin embryos (8.33 and 6.9% for 10 and 100 ng/ml, respectively). These observations indicate that the addition of @entity2 during post-thaw culture can improve the quality of @entity0 cryopreserved embryos.

title: Post-thaw culture in presence of insulin-like growth factor I improves the quality of XXXX cryopreserved embryos.

answer: @entity0


abstract: BACKGROUND: The annual number of parental karyotypes in cases of repeated @entity1 is increasing gradually in The Netherlands. The efficiency of offering parental karyotyping in couples with repeated @entity1 has not been evaluated before, especially not for the group with miscarriages at advanced maternal age. METHODS: A historical cohort study and nested case-control study were conducted, including couples with at least two miscarriages. Data were retrieved from medical records and telephone interviews. The obstetric follow-up was recorded for > or =2 years after the parental chromosome analysis. Data were analysed to compare ratios of carrier/non-carrier couples in whom maternal age was > or =36 or <36 years at the second, third or fourth and more @entity1 . A projected prevalence of carrier status of a @entity2 was calculated by extrapolating the number of included @entity0 to the original level of the total screening population. RESULTS: Forty-one couples with carrier status of a @entity2 and 74 couples without carrier status were included. No unbalanced offspring arose after the detection of a @entity2 . The risk of being a carrier was not significantly lower (as might be expected) when @entity0 were > or =36 years. Ascertainment after two, three, or four and more miscarriages did not change these findings. CONCLUSIONS: Karyotyping of 1324 couples ascertained for repeated @entity1 did not yield an unbalanced fetal chromosome pattern after the ascertainment of parental carrier status. In @entity0 with advanced maternal age, the frequency of carrier status was not lower than in younger @entity0 .

title: Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated XXXX .

answer: @entity1


abstract: PURPOSE: The optimum therapy for @entity5 ( @entity5 ) remains controversial. The primary objective of this study was to determine whether intensive @entity2 and @entity1 -based combination chemotherapy was effective in @entity0 with intracranial @entity5 . @entity0 AND METHODS: Twenty @entity0 were enrolled, aged 5 to 41 years (median, 13 years). Initial therapy included two courses of Regimen A ( @entity2 , @entity4 , @entity1 , and @entity3 ). @entity0 achieving a complete remission (CR) then received two courses of Regimen B ( @entity6 , @entity4 , and @entity3 ). Those in CR after four courses of treatment received one additional course of Regimen A and Regimen B, while those not in CR after four treatment courses underwent second-look surgery and/or irradiation. RESULTS: Sixteen of 17 @entity0 assessable for response after two courses of treatment achieved a CR or partial response (CR + partial response, 0.94; 95% CI, 0.73 to 1.0). With a median follow-up of 6.3 years, 14 of 20 @entity0 are alive without disease; eight @entity0 were without relapse or progression, of whom three received local irradiation in first complete remission in violation of protocol, and six @entity0 were in durable second or third complete remission after further chemotherapy and/or irradiation. The 5-year overall survival and event-free survival were 0.75 (95% CI, 0.56 to 0.94) and 0.36 (95% CI, 0.13 to 0.59), respectively. CONCLUSION: Intensive chemotherapy was effective in one-third of @entity0 in this study. Salvage therapy, including irradiation, was feasible in @entity0 with recurrent disease.

title: Primary chemotherapy for XXXX : results of the second international CNS germ cell study group protocol.

answer: @entity5


abstract: @entity2 ( @entity2 ) were developed to respect @entity0 autonomy. However, very few @entity0 have @entity2 , even in cases when major @entity1 surgery is to follow. To understand the reasons behind the low prevalence of @entity2 and to help decision making when @entity0 are incompetent, it is necessary to focus on the impact of prehospital practitioners, who may contribute to an increase in @entity2 by discussing them with @entity0 . The purpose of this study was to investigate self-rated communication skills and the attitudes of physicians potentially involved in the care of @entity1 @entity0 toward @entity2 .Self-administered questionnaires were sent to general practitioners, cardiologists, internists, and intensivists, including the Quality of Communication Score, divided into a General Communication score (QOCgen 6 items) and an End-of-life Communication score (QOCeol 7 items), as well as questions regarding opinions and practices in terms of @entity2 .One hundred sixty-four responses were received. QOCgen (mean (  SD)): 9.0/10 (1.0); QOCeol: 7.2/10 (1.7). General practitioners most frequently start discussions about @entity2 (74/149 [47%]) and are more prone to designate their own specialty (30/49 [61%], P<0.0001). Overall, only 57/159 (36%) physicians designated their own specialty; 130/158 (82%) physicians ask potential @entity1 @entity0 if they have @entity2 and 61/118 (52%) physicians who care for @entity1 @entity0 talk about @entity2 with some of them.The characteristics of physicians who do not talk about @entity2 with @entity0 were those who did not personally have @entity2 and those who work in private practices.One hundred thirty-three (83%) physicians rated the systematic mention of @entity0 ' @entity2 in the correspondence between physicians as good, while 114 (71%) at the @entity0 ' first registration in the private practice.Prehospital physicians rated their communication skills as good, whereas end-of-life communication was rated much lower. Only half of those surveyed speak about @entity2 with @entity1 @entity0 . The majority would prefer that physicians of another specialty, most frequently general practitioners, initiate conversation about @entity2 . In order to increase prehospital @entity2 incidence, efforts must be centered on improving practitioners' communication skills regarding death, by providing trainings to allow physicians to feel more at ease when speaking about end-of-life issues.

title: Advance Directives and Communication Skills of Prehospital Physicians Involved in the Care of Cardiovascular XXXX .

answer: @entity0