abstract: STUDY DESIGN: Longitudinal cohort. OBJECTIVE: To determine the cost per quality-adjusted life-year for lumbar epidural @entity2 injections (LESI). SUMMARY OF BACKGROUND DATA: Despite being a widely performed procedure, there are few studies evaluating the cost-effectiveness of LESIs. METHODS: @entity0 who had received LESI between June 2012 and July 2013 with EQ-5D scores available before and after LESIs but before any surgical intervention were identified. Costs were calculated on the basis of the Medicare Fee Schedule multiplied by the number of LESIs received between the 2 clinic visits. Quality-adjusted life-years (QALYs) were calculated using the EQ-5D. RESULTS: Of 421 @entity0 who had pre-LESI EQ-5D data, 323 (77%) had post-LESI data available; 200 females, 123 males, mean age: 59.2  14.2 years. Cost per LESI was  608, with most @entity0 receiving 3 LESIs for more than 1 year (range: 1-6 yr). Mean QALY gained was 0.005. One hundred forty-five @entity0 (45%) had a QALY gain (mean=0.117) at a cost of  62,175 per QALY gained; 127 @entity0 (40%) had a loss in QALY (mean=-0.120) and 51 @entity0 (15%) had no change in QALY. Fourteen of the 145 @entity0 who improved, and 29 of the 178 @entity0 who did not, have medical comorbidities that precluded surgery. Thirty-two (22%) of 131 @entity0 without medical comorbidities who improved and 57 (32%) of 149 @entity0 without medical comorbidities who did not improve subsequently had undergone surgery (P=0.015). CONCLUSION: LESI may not be cost-effective in @entity0 with @entity1 . For the 145 @entity0 who improved, cost per QALY gained was acceptable at  62,175. However, for the 178 @entity0 with no gain or a loss in QALY, the economics are not reportable with a cost per QALY gained being theoretically infinite. Further studies are needed to identify specific @entity0 populations who will benefit from LESI because the economic viability of LESI requires improved @entity0 selection. LEVEL OF EVIDENCE: 2.

title: Cost-effectiveness of Lumbar Epidural XXXX Injections.

answer: @entity2


abstract: UNASSIGNED: Phytoestrogens have structures similar to endogenous steroids and may induce or inhibit the response of hormone receptors. The objectives of the present study were to compare the effects of long-term vs. short-term grassland management in organic and conventional dairy production systems, compare organic and conventional production systems and assess seasonal variation on phytoestrogen concentrations in bulk- @entity1 milk. The concentrations of phytoestrogens were analyzed in bulk- @entity1 milk sampled three times in two subsequent years from 28 dairy farms: Fourteen organic (ORG) dairy farms with either short-term or long-term grassland management were paired with 14 conventional (CON) farms with respect to grassland management. Grassland management varied in terms of time since establishment. Short-term grassland management (SG) was defined as establishment or reseeding every fourth year or more often, and long-term grassland management (LG) was defined as less frequent establishment or reseeding. The proportion of red clover (Trifolium pretense L.) in the herbage was positively correlated with milk concentrations of the @entity0 isoflavone equol. Therefore, organically produced bulk- @entity1 milk contained more equol than conventionally produced milk, and milk from ORG-SG farms had more equol than milk from ORG-LG farms. Milk produced during the indoor-feeding periods had more equol than milk produced during the outdoor feeding period, because pastures contained less red clover than fields intended for silage production. Organically produced milk had also higher concentrations of the @entity0 lignan enterolactone, but in contrast to equol, concentrations increased in the outdoor-feeding periods compared to the indoor-feeding periods. There were no indications of fertility problems on ORG-SG farms who had the highest red clover proportions in the herbage. This study shows that production system, grassland management, and season affect milk concentrations of phytoestrogens. However, compared to soy products, milk concentrations of phytoestrogens are low and future studies are required to investigate if the intake of phytoestrogens from dairy products has physiological effects in @entity0 .

title: Phytoestrogens and Their Metabolites in Bulk- XXXX Milk: Effects of Farm Management and Season.

answer: @entity1


abstract: Coronary flow and transmembrane potentials of Purkinje and muscle fibers in reperfused @entity0 and @entity0 caused by permanent @entity1 were compared. Purkinje fibers in @entity0 at 24 h had markedly reduced resting potentials. Action potential amplitudes, and Vmax were reduced and duration markedly prolonged. In reperfused @entity0 , changes in Purkinje fiber transmembrane potentials were not as marked. Action potential duration in 3-day-old @entity0 were longer than at 24 h, but in reperfused @entity0 durations had returned to normal. Premature impulses conducted more rapidly in the reperfused infarct Purkinje system than in the permanently occluded. Other transmembrane potential parameters of Purkinje fibers in 3-day-old and 9- to 10-day-old reperfused and @entity0 were not significantly different from each other. The ventricular muscle cells that survived in reperfused @entity0 at all times also had reduced resting potentials and action potentials with decreased amplitudes, reduced Vmax, and prolonged durations. Almost no muscle cells survived in @entity0 . Therefore, reperfusion salvages subendocardial fibers and prevents some but not all of the electrophysiological abnormalities.

title: XXXX and reperfusion: effects on subendocardial cardiac fibers.

answer: @entity1


abstract: UNASSIGNED: We used insertional mutagenesis by @entity3 mediated transformation (ATMT) to isolate pathogenicity mutants of Colletotrichum higginsianum. From a collection of 7200 insertion mutants we isolated 75 mutants with reduced symptoms. 19 of these were affected in host penetration, while 17 were affected in later stages of @entity0 , like switching to @entity2 . For 16 mutants the location of T-DNA insertions could be identified by PCR. A potential plasma membrane H+-ATPase @entity4 was targeted in five independent insertion mutants. We genetically inactivated the Ku80 component of the non-homologous end-joining pathway in C. higginsianum to establish an efficient gene knockout protocol. Chpma2 deletion mutants generated by homologous recombination in the   Chku80 background form fully melanized appressoria but entirely fail to penetrate the host tissue and are non-pathogenic. The ChPMA2 gene is induced upon appressoria formation and @entity0 of A. thaliana. @entity4 activity is not important for vegetative growth of saprophytically growing mycelium, since the mutant shows no growth penalty under these conditions. Colletotrichum higginsianum codes for a closely related gene (ChPMA1), which is highly expressed under most growth conditions. ChPMA1 is more similar to the homologous @entity1 genes for plasma membrane pumps. We propose that expression of a specific proton pump early during @entity0 may be common to many appressoria forming fungal pathogens as we found ChPMA2 orthologs in several plant pathogenic fungi.

title: A Genetic Screen for Pathogenicity Genes in the Hemibiotrophic Fungus Colletotrichum higginsianum Identifies the Plasma Membrane Proton Pump XXXX Required for Host Penetration.

answer: @entity4


abstract: PURPOSE: To assess the prognostic significance of @entity1 ( @entity1 ), maximum @entity2 diameter (MTD), high-grade @entity4 , perineural invasion, and length of positive surgical margins after robot-assisted radical prostatectomy (RARP). METHODS: A single-institution prospective analysis of all @entity0 who underwent RARP for @entity3 was performed between January 2005 and June 2013. The primary end point was biochemical recurrence-free survival (BRFS). BRFS was estimated using the Kaplan-Meier method and compared to that from the log-rank test. Cox* s proportional hazards regression univariate and multivariate analyses were performed to define the prognostic factors. RESULTS: Overall, 742 @entity0 were included. After a median follow-up of 31.4 months, biochemical recurrence occurred in 80 @entity0 (10.8%). BRFS was 93%, 87%, and 80.7% at 1, 3, and 5 years, respectively. Progression to local recurrence occurred in 49 @entity0 (6.6%). During the follow-up period, 3 @entity0 experienced progression to @entity1 and were treated with hormonotherapy. No @entity0 died of disease during the study period. In multivariate analyses, Gleason score was the strongest predictor of BRFS (hazard ratio [HR] = 3.4; P<0.001). There were 3 other predictive factors of BRFS were @entity1 (HR = 7.64; P = 0.005), MTD (HR = 4.04; P =0.009), and margin length>= 3mm (HR = 1.25; P = 0.04). CONCLUSION: In the era of serum prostate-specific antigen testing maturity in conjunction with a single approach to extirpation of the prostate gland by RARP, @entity1 , MTD, and positive surgical margins>= 3mm are prognostic factors associated with BRFS after RARP. Consideration could be given to incorporate them in the pathology report of the radical prostatectomy specimens and they could assist physicians in clinical decision making.

title: Influence of pathological factors on oncological outcomes after robot-assisted radical prostatectomy for XXXX : Results of a prospective study.

answer: @entity3


abstract: PURPOSE: This study aimed to compare procedures for @entity2 tracking (DTT) using a gimbal-mounted linac between centres in Japan (KU-IBRI) and Belgium (UZB), to quantify @entity4 ( @entity4 ), and to estimate @entity2 -fiducial uncertainties and @entity3 margins. METHODS: Twenty-two @entity0 were evaluated. @entity4 was divided into components originating from the @entity0 , fraction, segment, and residuals. RESULTS: KU-IBRI applied DTT to @entity1 , while UZB treated both the lung and liver. @entity0 from UZB were younger and had a higher body mass index. DTT procedures differed in the use of body fixation, correction for set-up error, type of fiducial markers, and goodness of fit of correlation model. @entity4 was larger at UZB in the intra-fraction components, whereas the @entity2 -fiducial uncertainties were estimated to be larger at KU-IBRI. These results ultimately led to similar @entity3 margins at both centres (2.1, 4.2, and 2.6mm for KU-IBRI; 2.4, 3.6, and 2.0mm for UZB in LR, AP, and SI, respectively, for 99% coverage of @entity0 ). CONCLUSION: Several differences in procedures and @entity0 characteristics were observed that affected @entity4 and @entity2 -fiducial uncertainties. This analysis confirmed similar accuracy in DTT delivery and adequate @entity3 margins in the different centres based on their local specific workflows.

title: A multi-centre analysis of treatment procedures and error components in XXXX tracking radiotherapy.

answer: @entity2


abstract: UNASSIGNED: Antioxidants have not reduced the burden of @entity0 , and current evidence suggests a beneficial role of oxidative stress, via NADPH oxidase (Nox) upregulation, in endothelial function. Homocysteine thiolactone (HcyT) induces @entity2 and this correlates with increased vascular oxidative stress. AIMS: To determine if pharmacological inhibition of Nox could impair @entity2 . METHODS: Abdominal aorta were excised from New Zealand White @entity1 (n=6), cut into rings and sequentially mounted in organ baths. Rings were preincubated with 0.55 M homocysteine thiolactone for 1hr, or combinations of putative Nox inhibitors (plumbagin for @entity4 , gp91ds-tat for @entity5 , and ML090 for @entity3 ), 30 minutes prior to the addition of HcyT, followed by a dose response curve to acetylcholine on phenylephrine preconstricted rings. RESULTS: Plumbagin, ML090 + gp91ds-tat and HcyT reduced responses to acetylcholine, and Plumbagin + Hcyt caused constriction to acetylcholine, which was normalised to plumbagin by ML090. Plumbagin + ML090 or plumbagin + gp91ds-tat completely impaired the effect of acetylcholine. ML090 inhibited the effect of HcyT on reduced response to acetylcholine, whereas gp91ds-tat had no effect. CONCLUSION: Inhibition of @entity3 prevents, whereas inhibition of @entity4 worsens acetylcholine induced blood vessel relaxation caused by HcyT, while @entity5 inhibition has no effect. However combinations of Nox inhibitors worsen acetylcholine induced blood vessel relaxation. These results suggest that there is cross-talk between Nox isoforms during physiological and pathophysiological processes. This article is protected by copyright. All rights reserved.

title: Role of Nox inhibitors plumbagin, ML090 and gp91ds-tat peptide on homocysteine thiolactone induced XXXX .

answer: @entity2


abstract: Determinants of glomerular ultrafiltration were studied by micropuncture in clamped (n = 11) and unclamped (n = 7) kidneys of two-kidney @entity1 @entity0 and compared to 15 controls. Infusion of the @entity2 antagonist and @entity4 lowered the blood pressure significantly. Glomerular capillary pressure ( @entity3 ) in clamped kidneys was decreased to 56 +/- (SD) 3 vs. 61 +/- 3 mm Hg in controls. Early proximal flow rate (EPFR) was decreased to 20 +/- 1 vs. 26 +/- 2 nl/min in controls, at an unchanged single nephron filtration fraction (SNFF), indicating a reduced glomerular plasma flow (SNGPF). Preglomerular resistance (RA) was increased by 21%. In unclamped kidneys @entity3 was increased to 65 +/- 2 mm Hg. EPFR was increased to 32 +/- 2 nl/min, indicating, at an unchanged SNFF, an increased SNGPF. RA increased by 51%, whereas postglomerular resistance declined by 25%. The ultrafiltration coefficient was reduced by 24% in unclamped kidneys. Our results indicate that in clamped kidneys an increase of RA causes a reduction of @entity3 and hence a reduction of pressure at the baroreceptor site which may act as a trigger mechanism for renin release.

title: XXXX in @entity0 : a model for unilateral renal artery stenosis in man.

answer: @entity1


abstract: Determinants of glomerular ultrafiltration were studied by micropuncture in clamped (n = 11) and unclamped (n = 7) kidneys of two-kidney @entity1 @entity0 and compared to 15 controls. Infusion of the @entity2 antagonist and @entity4 lowered the blood pressure significantly. Glomerular capillary pressure ( @entity3 ) in clamped kidneys was decreased to 56 +/- (SD) 3 vs. 61 +/- 3 mm Hg in controls. Early proximal flow rate (EPFR) was decreased to 20 +/- 1 vs. 26 +/- 2 nl/min in controls, at an unchanged single nephron filtration fraction (SNFF), indicating a reduced glomerular plasma flow (SNGPF). Preglomerular resistance (RA) was increased by 21%. In unclamped kidneys @entity3 was increased to 65 +/- 2 mm Hg. EPFR was increased to 32 +/- 2 nl/min, indicating, at an unchanged SNFF, an increased SNGPF. RA increased by 51%, whereas postglomerular resistance declined by 25%. The ultrafiltration coefficient was reduced by 24% in unclamped kidneys. Our results indicate that in clamped kidneys an increase of RA causes a reduction of @entity3 and hence a reduction of pressure at the baroreceptor site which may act as a trigger mechanism for renin release.

title: @entity1 in XXXX : a model for unilateral renal artery stenosis in man.

answer: @entity0


abstract: BACKGROUND: Lipid emulsion (LE) has been successfully used for resuscitation of local anesthetic @entity2 caused by @entity1 @entity3 . Opioid receptors have been shown to play a key role in cardio protection. We explored whether this rescue action of LE is mediated through opioid receptors. METHODS: Asystole was induced by @entity1 (10 mg/kg over 20 seconds, IV) in young male @entity0 , and resuscitation with LE (intralipid 20%; 5 mL/kg bolus and 0.5 mL/kg/min maintenance) was started immediately. The @entity0 were pretreated 2 minutes before inducing asystole with nonselective opioid receptor antagonists such as @entity4 and @entity6 , as well as highly selective opioid receptor antagonists for subtype k,   , and    or @entity5 buffer solution as a control. Heart rates and ejection fractions were measured using echocardiography. RESULTS: LE rescue of @entity1 @entity2 was prevented by high-dose (1 mg/kg) @entity4 but not by lower doses of @entity4 (1, 5, and 10   g/kg), by @entity6 (which does not cross the blood-brain barrier), and by a selective   - and k-opioid receptor antagonists at a higher (10 mg/kg) dose. Successful LE rescue was not affected by highly selective   -opioid receptor antagonists.   -Opioid receptor antagonist (10 mg/kg) pretreatment also resulted in reduced phosphorylation level of cardiac glycogen synthase kinase-3b in @entity0 that were not resuscitated by LE compared with control. CONCLUSIONS: Our data highlight the involvement of peripheral   - and k-opioid receptors in the rescue action of LE.

title: Involvement of Opioid Receptors in the Lipid Rescue of @entity1 -Induced XXXX .

answer: @entity2


abstract: BACKGROUND: Lipid emulsion (LE) has been successfully used for resuscitation of local anesthetic @entity2 caused by @entity1 @entity3 . Opioid receptors have been shown to play a key role in cardio protection. We explored whether this rescue action of LE is mediated through opioid receptors. METHODS: Asystole was induced by @entity1 (10 mg/kg over 20 seconds, IV) in young male @entity0 , and resuscitation with LE (intralipid 20%; 5 mL/kg bolus and 0.5 mL/kg/min maintenance) was started immediately. The @entity0 were pretreated 2 minutes before inducing asystole with nonselective opioid receptor antagonists such as @entity4 and @entity6 , as well as highly selective opioid receptor antagonists for subtype k,   , and    or @entity5 buffer solution as a control. Heart rates and ejection fractions were measured using echocardiography. RESULTS: LE rescue of @entity1 @entity2 was prevented by high-dose (1 mg/kg) @entity4 but not by lower doses of @entity4 (1, 5, and 10   g/kg), by @entity6 (which does not cross the blood-brain barrier), and by a selective   - and k-opioid receptor antagonists at a higher (10 mg/kg) dose. Successful LE rescue was not affected by highly selective   -opioid receptor antagonists.   -Opioid receptor antagonist (10 mg/kg) pretreatment also resulted in reduced phosphorylation level of cardiac glycogen synthase kinase-3b in @entity0 that were not resuscitated by LE compared with control. CONCLUSIONS: Our data highlight the involvement of peripheral   - and k-opioid receptors in the rescue action of LE.

title: Involvement of Opioid Receptors in the Lipid Rescue of XXXX -Induced @entity2 .

answer: @entity1


abstract: BACKGROUND: Nail clipping microscopy is a valuable diagnostic tool in @entity4 but has not been explored for the diagnosis of @entity6 caused by @entity2 . The objective of this study was to try to establish criteria for the diagnosis of @entity2 by this method. METHODS: Cross-sectional study of adult @entity0 with clear-cut @entity2 is divided into 2 groups: (1) with @entity6 and (2) with clinically normal nails. The @entity0 were evaluated regarding gender and age, among other clinical variables. The samples were coded to allow blinded microscopic interpretation for nail plate and subungual region thickness and for the presence or absence of corneocytes, neutrophils, serous lakes, blood, bacteria, onychokaryosis, @entity3 nuclear shadows, and fungi. RESULTS: Ninety-six @entity0 with @entity2 were enrolled in this study. There were 40 male and 56 female subjects; ages varied from 16 to 87 years (mean, 51 years). @entity6 was detected in 51 @entity0 (53%). On average, nail plate thickness and subungual region thickness measured 0.44 and 0.19 mm in the @entity6 group and 0.41 and 0.14 mm in the clinically normal group (P > 0.05). @entity5 presented 4.5 layers of corneocytes, on average, in contrast to the average of 2.4 in the clinically normal-looking nails (P = 0.0004). Neutrophils (12%), serous lakes (46%), blood collections (11%), bacteria (74%), fungi (20%), onychokaryosis, and @entity3 nuclear shadows were all more common in the @entity6 group but not in a statistically significant standard when compared with the other group (P > 0.05). CONCLUSIONS: Nail clippings from @entity0 with @entity2 present abnormally thickened subungual region with prominent hypercorneocytosis, serous lakes, bacteria, neutrophils, and blood collections. If fungi are present, usually there are spores. Clinically, normal-looking nails in @entity0 with @entity2 can present @entity1 .

title: Microscopic Nail Clipping Findings in XXXX With Psoriasis.

answer: @entity0


abstract: UNASSIGNED: @entity3 is increasing at an alarming rate, making it a worldwide epidemic. As the population ages and life expectancy increases, this trend is not likely to change. @entity2 ( @entity2 )-induced adverse left ventricular (LV) remodeling is responsible for nearly 70% of @entity3 cases. The adverse remodeling process involves an extension of the border zone (BZ) adjacent to an @entity2 , which is normally perfused but shows myofiber @entity1 . To improve @entity0 -specific modeling of cardiac mechanics, we sought to create a finite element model of the @entity0 LV with BZ and @entity2 morphologies integrated directly from delayed-enhancement magnetic resonance (DE-MR) images. Instead of separating the LV into discrete regions (e.g., the @entity2 , BZ, and remote regions) with each having a homogeneous myocardial material property, we assumed a functional relation between the DE-MR image pixel intensity and myocardial stiffness and contractility-we considered a linear variation of material properties as a function of DE-MR image pixel intensity, which is known to improve the accuracy of the model's response. The finite element model was then calibrated using measurements obtained from the same @entity0 -namely, 3D strain measurements-using complementary spatial modulation of magnetization magnetic resonance (CSPAMM-MR) images. This led to an average circumferential strain error of 8.9% across all American Heart Association (AHA) segments. We demonstrate the utility of our method for quantifying smooth regional variations in myocardial contractility using cardiac DE-MR and CSPAMM-MR images acquired from a 78-yr-old @entity0 who experienced an @entity2 approximately 1   yr prior. We found a remote myocardial diastolic stiffness of C0  =0.102   kPa, and a remote myocardial contractility of Tmax  =146.9   kPa, which are both in the range of previously published normal @entity0 values. Moreover, we found a normalized pixel intensity range of 30% for the BZ, which is consistent with the literature. Based on these regional myocardial material properties, we used our finite element model to compute @entity0 -specific diastolic and systolic LV myofiber stress distributions, which cannot be measured directly. One of the main driving forces for adverse LV remodeling is assumed to be an abnormally high level of ventricular wall stress, and many existing and new treatments for @entity3 fundamentally attempt to normalize LV wall stress. Thus, our noninvasive method for estimating smooth regional variations in myocardial contractility should be valuable for optimizing new surgical or medical strategies to limit the chronic evolution from infarction to @entity3 .

title: A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted XXXX Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging.

answer: @entity0


abstract: BACKGROUND: This study aimed to compare the utility of the number of positive lymph nodes with the lymph node ratio (LNR) in predicting survival after resection of @entity2 . METHODS: A retrospective analysis of 142 consecutive @entity0 who underwent radical resection of @entity2 was performed. A total of 3066 regional lymph nodes were resected. The median number of nodes per @entity0 was 21. The optimal cutoff values for the number of positive nodes and the LNR were determined using the Chi square scores calculated by the Cox proportional hazards regression model. RESULTS: Nodal disease was found in 59 @entity0 (42  %). In the subsequent analysis of the impact that nodal status has on survival, 18 @entity0 with R1/2 resection and 6 @entity0 with @entity1 who did not survive for more than 5  years after resection were excluded. The optimal cutoff value for the number of positive nodes was 1, and the optimal cutoff value for the LNR was 5  %. Univariate analysis identified both the number of positive nodes (0, 1, or >= 2; P  =  0.005) and the LNR (0, 0-5, or >5  %; P  =  0.007) as significant prognostic factors. Multivariate analysis identified the number of positive nodes but not the LNR as an independent prognostic factor (P  =  0.012). The 5-year survival rates were 64  % for the @entity0 with no positive nodes, 46  % for the @entity0 with one positive node, and 28  % for the @entity0 with two or more positive nodes. CONCLUSIONS: The number of positive lymph nodes predicts survival better than the LNR after resection of @entity2 , provided that nodal evaluation is sufficient.

title: Comparison of Number Versus Ratio of Positive Lymph Nodes in the Assessment of Lymph Node Status in XXXX .

answer: @entity2


abstract: OBJECTIVE: To assess the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on digital ulcer (DU) healing in @entity1 ( @entity1 ). METHODS: Randomised, placebo-controlled study in @entity0 with @entity1 to assess the effect of sildenafil 20   mg or placebo, three times daily for 12   weeks, on ischaemic DU healing. The primary end point was the time to healing for each DU. Time to healing was compared between groups using Cox models for clustered data (two-sided tests, p=0.05). RESULTS: Intention-to-treat analysis involved 83 @entity0 with a total of 192 DUs (89 in the sildenafil group and 103 in the placebo group). The HR for DU healing was 1.33 (0.88 to 2.00) (p=0.18) and 1.27 (0.85 to 1.89) (p=0.25) when adjusted for the number of DUs at entry, in favour of sildenafil. In the per protocol population, the HRs were 1.49 (0.98 to 2.28) (p=0.06) and 1.43 (0.93 to 2.19) p=0.10. The mean number of DUs per @entity0 was lower in the sildenafil group compared with the placebo group at week (W) 8 (1.23  1.61 vs 1.79  2.40 p=0.04) and W12 (0.86  1.62 vs 1.51  2.68, p=0.01) resulting from a greater healing rate (p=0.01 at W8 and p=0.03 at W12). CONCLUSIONS: The primary end point was not reached in intention-to-treat, partly because of an unexpectedly high healing rate in the placebo group. We found a significant decrease in the number of DUs in favour of sildenafil compared with placebo at W8 and W12, confirming a sildenafil benefit. TRIAL REGISTRATION NUMBER: NCT01295736.

title: Efficacy of sildenafil on ischaemic digital ulcer healing in XXXX : the placebo-controlled SEDUCE study.

answer: @entity1


abstract: OBJECTIVE: To assess the long-term sustainability of continuing professional development (CPD) training in pharmacy practice and @entity1 . METHODS: This was a 3-year posttrial survey of pharmacists who had participated in an unblinded randomized controlled trial of CPD. The online survey assessed @entity0 ' perceptions of pharmacy practice, @entity1 , and sustainability of CPD. Differences between groups on the posttrial survey responses and changes from the trial's follow-up survey to the posttrial survey responses within the intervention group were compared. RESULTS: Of the 91 pharmacists who completed the original trial, 72 (79%) participated in the sustainability survey. Compared to control @entity0 , a higher percentage of intervention @entity0 reported in the sustainability survey that they had utilized the CPD concept (45.7% vs 8.1%) and identified personal learning objectives (68.6% vs 43.2%) during the previous year. Compared to their follow-up survey responses, lower percentages of intervention @entity0 reported identifying personal learning objectives (94.3% vs 68.6%), documenting their learning plan (82.9% vs 22.9%) and participating in learning by doing (42.9% vs 14.3%) in the sustainability survey. In the intervention group, many of the improvements to pharmacy practice items were sustained over the 3-year period but were not significantly different from the control group. CONCLUSION: Sustainability of a CPD intervention over a 3-year varied. While CPD-trained pharmacists reported utilizing CPD concepts at a higher rate than control pharmacists, their CPD @entity1 diminished over time.

title: The sustainability of improvements from continuing professional development in pharmacy practice and XXXX .

answer: @entity1


abstract: Anticitrullinated peptide/protein antibodies ( @entity10 ), which are highly specific for @entity3 ( @entity3 ), may be found in some @entity0 with other systemic @entity6 . The clinical significance of @entity10 in patients with @entity11 ( @entity11 ), a @entity2 characterized by the association of @entity9 , @entity4 , @entity8 , and/or @entity5 , has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. @entity10 -positive @entity11 @entity0 were first identified among a French multicenter registry of @entity0 with @entity11 . Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of @entity11 @entity0 with @entity10 . The 17 collected @entity0 were retrospectively studied using a standardized questionnaire and compared with 34 unselected @entity10 -negative @entity11 @entity0 in a case-control study. All @entity10 -positive @entity11 @entity0 suffered from @entity5 versus 41% in the control group (P<0.0001). The number of swollen joints was significantly higher (7.0  5.0 vs 2.9  3.9, P<0.005), with a distribution resembling that of @entity3 . Radiographic damages were also more frequent in @entity10 -positive @entity11 @entity0 (87% vs 11%, P<0.0001). Aside from a significantly higher transfer factor for @entity7 in @entity10 - @entity11 @entity0 , lung, muscle, and skin involvements had similar incidences, patterns, and severity in both groups. Although Nonbiologic treatments were similarly used in both groups, @entity10 -positive @entity0 received biologics more frequently (59% vs 12%, P<0.0008), mostly due to refractory @entity5 (n=9). Eight patients received anti-Cluster of differentiation 20 (CD20) monoclonal antibodies (mAbs) with good efficacy and tolerance, whereas 2 of the 5 @entity0 treated with antitumor @entity1 factor drugs had worsened @entity9 and/or @entity4 . After a >7-year mean follow-up, extra-articular outcomes and survival were not different. @entity10 -positive @entity11 @entity0 showed an overlapping @entity3 - @entity11 syndrome, were at high risk of @entity5 , and might experience @entity11 flare when treated with antitumor @entity1 factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements.

title: In @entity11 , XXXX are associated with severe and erosive @entity5 : an overlapping @entity3 and @entity11 .

answer: @entity10


abstract: Anticitrullinated peptide/protein antibodies ( @entity10 ), which are highly specific for @entity3 ( @entity3 ), may be found in some @entity0 with other systemic @entity6 . The clinical significance of @entity10 in patients with @entity11 ( @entity11 ), a @entity2 characterized by the association of @entity9 , @entity4 , @entity8 , and/or @entity5 , has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. @entity10 -positive @entity11 @entity0 were first identified among a French multicenter registry of @entity0 with @entity11 . Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of @entity11 @entity0 with @entity10 . The 17 collected @entity0 were retrospectively studied using a standardized questionnaire and compared with 34 unselected @entity10 -negative @entity11 @entity0 in a case-control study. All @entity10 -positive @entity11 @entity0 suffered from @entity5 versus 41% in the control group (P<0.0001). The number of swollen joints was significantly higher (7.0  5.0 vs 2.9  3.9, P<0.005), with a distribution resembling that of @entity3 . Radiographic damages were also more frequent in @entity10 -positive @entity11 @entity0 (87% vs 11%, P<0.0001). Aside from a significantly higher transfer factor for @entity7 in @entity10 - @entity11 @entity0 , lung, muscle, and skin involvements had similar incidences, patterns, and severity in both groups. Although Nonbiologic treatments were similarly used in both groups, @entity10 -positive @entity0 received biologics more frequently (59% vs 12%, P<0.0008), mostly due to refractory @entity5 (n=9). Eight patients received anti-Cluster of differentiation 20 (CD20) monoclonal antibodies (mAbs) with good efficacy and tolerance, whereas 2 of the 5 @entity0 treated with antitumor @entity1 factor drugs had worsened @entity9 and/or @entity4 . After a >7-year mean follow-up, extra-articular outcomes and survival were not different. @entity10 -positive @entity11 @entity0 showed an overlapping @entity3 - @entity11 syndrome, were at high risk of @entity5 , and might experience @entity11 flare when treated with antitumor @entity1 factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements.

title: In @entity11 , @entity10 are associated with severe and erosive XXXX : an overlapping @entity3 and @entity11 .

answer: @entity5


abstract: Anticitrullinated peptide/protein antibodies ( @entity10 ), which are highly specific for @entity3 ( @entity3 ), may be found in some @entity0 with other systemic @entity6 . The clinical significance of @entity10 in patients with @entity11 ( @entity11 ), a @entity2 characterized by the association of @entity9 , @entity4 , @entity8 , and/or @entity5 , has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. @entity10 -positive @entity11 @entity0 were first identified among a French multicenter registry of @entity0 with @entity11 . Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of @entity11 @entity0 with @entity10 . The 17 collected @entity0 were retrospectively studied using a standardized questionnaire and compared with 34 unselected @entity10 -negative @entity11 @entity0 in a case-control study. All @entity10 -positive @entity11 @entity0 suffered from @entity5 versus 41% in the control group (P<0.0001). The number of swollen joints was significantly higher (7.0  5.0 vs 2.9  3.9, P<0.005), with a distribution resembling that of @entity3 . Radiographic damages were also more frequent in @entity10 -positive @entity11 @entity0 (87% vs 11%, P<0.0001). Aside from a significantly higher transfer factor for @entity7 in @entity10 - @entity11 @entity0 , lung, muscle, and skin involvements had similar incidences, patterns, and severity in both groups. Although Nonbiologic treatments were similarly used in both groups, @entity10 -positive @entity0 received biologics more frequently (59% vs 12%, P<0.0008), mostly due to refractory @entity5 (n=9). Eight patients received anti-Cluster of differentiation 20 (CD20) monoclonal antibodies (mAbs) with good efficacy and tolerance, whereas 2 of the 5 @entity0 treated with antitumor @entity1 factor drugs had worsened @entity9 and/or @entity4 . After a >7-year mean follow-up, extra-articular outcomes and survival were not different. @entity10 -positive @entity11 @entity0 showed an overlapping @entity3 - @entity11 syndrome, were at high risk of @entity5 , and might experience @entity11 flare when treated with antitumor @entity1 factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements.

title: In XXXX , @entity10 are associated with severe and erosive @entity5 : an overlapping @entity3 and @entity11 .

answer: @entity11


abstract: Anticitrullinated peptide/protein antibodies ( @entity10 ), which are highly specific for @entity3 ( @entity3 ), may be found in some @entity0 with other systemic @entity6 . The clinical significance of @entity10 in patients with @entity11 ( @entity11 ), a @entity2 characterized by the association of @entity9 , @entity4 , @entity8 , and/or @entity5 , has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. @entity10 -positive @entity11 @entity0 were first identified among a French multicenter registry of @entity0 with @entity11 . Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of @entity11 @entity0 with @entity10 . The 17 collected @entity0 were retrospectively studied using a standardized questionnaire and compared with 34 unselected @entity10 -negative @entity11 @entity0 in a case-control study. All @entity10 -positive @entity11 @entity0 suffered from @entity5 versus 41% in the control group (P<0.0001). The number of swollen joints was significantly higher (7.0  5.0 vs 2.9  3.9, P<0.005), with a distribution resembling that of @entity3 . Radiographic damages were also more frequent in @entity10 -positive @entity11 @entity0 (87% vs 11%, P<0.0001). Aside from a significantly higher transfer factor for @entity7 in @entity10 - @entity11 @entity0 , lung, muscle, and skin involvements had similar incidences, patterns, and severity in both groups. Although Nonbiologic treatments were similarly used in both groups, @entity10 -positive @entity0 received biologics more frequently (59% vs 12%, P<0.0008), mostly due to refractory @entity5 (n=9). Eight patients received anti-Cluster of differentiation 20 (CD20) monoclonal antibodies (mAbs) with good efficacy and tolerance, whereas 2 of the 5 @entity0 treated with antitumor @entity1 factor drugs had worsened @entity9 and/or @entity4 . After a >7-year mean follow-up, extra-articular outcomes and survival were not different. @entity10 -positive @entity11 @entity0 showed an overlapping @entity3 - @entity11 syndrome, were at high risk of @entity5 , and might experience @entity11 flare when treated with antitumor @entity1 factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements.

title: In @entity11 , @entity10 are associated with severe and erosive @entity5 : an overlapping @entity3 and XXXX .

answer: @entity11


abstract: Anticitrullinated peptide/protein antibodies ( @entity10 ), which are highly specific for @entity3 ( @entity3 ), may be found in some @entity0 with other systemic @entity6 . The clinical significance of @entity10 in patients with @entity11 ( @entity11 ), a @entity2 characterized by the association of @entity9 , @entity4 , @entity8 , and/or @entity5 , has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. @entity10 -positive @entity11 @entity0 were first identified among a French multicenter registry of @entity0 with @entity11 . Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of @entity11 @entity0 with @entity10 . The 17 collected @entity0 were retrospectively studied using a standardized questionnaire and compared with 34 unselected @entity10 -negative @entity11 @entity0 in a case-control study. All @entity10 -positive @entity11 @entity0 suffered from @entity5 versus 41% in the control group (P<0.0001). The number of swollen joints was significantly higher (7.0  5.0 vs 2.9  3.9, P<0.005), with a distribution resembling that of @entity3 . Radiographic damages were also more frequent in @entity10 -positive @entity11 @entity0 (87% vs 11%, P<0.0001). Aside from a significantly higher transfer factor for @entity7 in @entity10 - @entity11 @entity0 , lung, muscle, and skin involvements had similar incidences, patterns, and severity in both groups. Although Nonbiologic treatments were similarly used in both groups, @entity10 -positive @entity0 received biologics more frequently (59% vs 12%, P<0.0008), mostly due to refractory @entity5 (n=9). Eight patients received anti-Cluster of differentiation 20 (CD20) monoclonal antibodies (mAbs) with good efficacy and tolerance, whereas 2 of the 5 @entity0 treated with antitumor @entity1 factor drugs had worsened @entity9 and/or @entity4 . After a >7-year mean follow-up, extra-articular outcomes and survival were not different. @entity10 -positive @entity11 @entity0 showed an overlapping @entity3 - @entity11 syndrome, were at high risk of @entity5 , and might experience @entity11 flare when treated with antitumor @entity1 factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements.

title: In @entity11 , @entity10 are associated with severe and erosive @entity5 : an overlapping XXXX and @entity11 .

answer: @entity3


abstract: OBJECTIVE: To analyze the relationship between different level of surplus energy and @entity4 health among middle-aged and elder females. METHODS: Multi-stage stratified random sampling method was used and 650 residents aged 40 - 60 years in Xi' an City were selected for measurement of body shape, function, blood biochemistry and psychology indicators and questionnaire survey of nutritional and physical activity status. The subjects were divided into the following four groups according to surplus energy (SE) classification by using of quartile method, When SE < @entity3 for the low surplus energy group, @entity3  <= SE < @entity2 for the moderate surplus energy group, @entity2  <= SE < @entity1 for the high surplus energy group, @entity1 < SE for higher surplus energy group. RESULTS: Body mass, waist circumference, hip circumference, arm skinfold thickness, abdominal skinfold thickness, leg skinfold thickness, body mass index, waist-hip ratio and body fat rate among surplus energy groups was statistically significant (P < 0. 05 or P < 0. 01). Cardiopulmonary function and mental health level of the high energy group and the moderate surplus energy group were better than the low surplus energy group and higher surplus energy group, it was statistically significant (P <0. 05), and the level of @entity0 , TG, TC, LDL declined significantly and the level of HDL increased remarkably (P < 0. 05). CONCLUSION: The energy intake of dietary and the energy consumption of physical activity are factors influencing the level of @entity4 health.

title: [Level of different energy metabolism on XXXX of women in Xi' an City].

answer: @entity4


abstract: UNASSIGNED: Current hypotheses postulate a relationship between @entity4 and freezing of gait ( @entity6 ) in @entity2 ( @entity2 ). Hitherto, most evidence comes from entirely clinical approaches, while knowledge about this relationship on the morphological level is sparse. The aim of this study was therefore to assess the overlap of gray matter @entity3 associated with @entity6 and @entity4 in @entity2 . We included 18 @entity2 @entity0 with @entity6 and 20 without @entity6 in our analysis. A voxel-based morphometry approach was used to reveal voxel clusters in the gray matter which were associated with @entity6 and @entity4 as measured by the Frontal Assessment Battery, respectively. Conjunction analysis was applied to detect overlaps of the associated patterns. @entity6 correlated with different cortical clusters in the frontal and parietal lobes, whereas those associated with the @entity5 scores were, although widespread, widely confined to the frontal lobe. Conjunction analysis revealed a significant cluster of gray matter loss in the right dorsolateral prefrontal cortex. We could show that the patterns of @entity1 associated with @entity6 and @entity4 (as measured by the @entity5 ) share atrophic changes in the same cortical areas. However, there is also a considerable number of cortical areas where neurodegenerative changes are only unique for either sign. Particularly, the involvement of parietal lobe areas seems to be more specific for @entity6 .

title: Do XXXX and freezing of gait in @entity2 share the same neuroanatomical correlates?

answer: @entity4


abstract: UNASSIGNED: Current hypotheses postulate a relationship between @entity4 and freezing of gait ( @entity6 ) in @entity2 ( @entity2 ). Hitherto, most evidence comes from entirely clinical approaches, while knowledge about this relationship on the morphological level is sparse. The aim of this study was therefore to assess the overlap of gray matter @entity3 associated with @entity6 and @entity4 in @entity2 . We included 18 @entity2 @entity0 with @entity6 and 20 without @entity6 in our analysis. A voxel-based morphometry approach was used to reveal voxel clusters in the gray matter which were associated with @entity6 and @entity4 as measured by the Frontal Assessment Battery, respectively. Conjunction analysis was applied to detect overlaps of the associated patterns. @entity6 correlated with different cortical clusters in the frontal and parietal lobes, whereas those associated with the @entity5 scores were, although widespread, widely confined to the frontal lobe. Conjunction analysis revealed a significant cluster of gray matter loss in the right dorsolateral prefrontal cortex. We could show that the patterns of @entity1 associated with @entity6 and @entity4 (as measured by the @entity5 ) share atrophic changes in the same cortical areas. However, there is also a considerable number of cortical areas where neurodegenerative changes are only unique for either sign. Particularly, the involvement of parietal lobe areas seems to be more specific for @entity6 .

title: Do @entity4 and freezing of gait in XXXX share the same neuroanatomical correlates?

answer: @entity2


abstract: BACKGROUND: Intracranial @entity5 is rare, and most cases occur in the skull base. Intradural @entity5 is even rarer. CASE: Here, we describe a case of @entity5 with a radiation history for @entity2 and a radical prostatectomy for @entity3 15 and 8 years earlier, respectively. A 67-year-old @entity0 presented with a 3-week @entity7 and @entity10 . Computed tomography and magnetic resonance images of the brain revealed a dural-based mass in the left temporal area. Under the impression of a @entity4 , a resection and an intraoperative squash cytology were done. A necrotic dirty background as well as bluish-to-pinkish myxoid stroma were characteristic; the nuclei of highly @entity1 cells were hyperchromatic to vesicular with an occasional ground-glass appearance. The cytoplasm was of an eosinophilic hyalinized condensed morphology with an occasional granular appearance. Histologically, the lobulated mass was composed of hypercellular lobules of well-differentiated chondrocytes intermixed with anaplastic pleomorphic cells and diagnosed as a conventional grade III @entity5 . These cells were immunoreactive for D2-40, @entity9 protein and @entity6 . Brain invasion was also found. CONCLUSION: Albeit rare, dural-based @entity5 should be considered in the differential diagnosis for @entity8 , especially in the case of previous radiation therapy.    2015 S. Karger AG, Basel.

title: Squash Cytology of a Dural-Based High-Grade Chondrosarcoma May Mimic That of XXXX in the Central Nervous System.

answer: @entity4


abstract: UNASSIGNED: Hereditary protein S (PS) deficiency is an independent risk factor for @entity2 . However, the correlation between PS and arterial @entity1 , such as @entity5 , is not clear. The present study focused on the molecular mechanisms underlying @entity0 caused by a PS gene mutation in one family. The activity of @entity4 , protein  C and PS in the plasma of the proband was measured, and the genes encoding PS were amplified and sequenced. The cellular localization and expression of PS were analyzed in HEK  -293 cells. The proband was a 50  -year  -old male. Plasma PS activity of the proband was 38.9%, which was significantly decreased compared with normal levels. Sequencing analysis revealed a @entity6 @entity7 mutation on exon  12. This frameshift mutation converts Asp496 in the precursor PS into the termination codon. In addition, the @entity6 mutation was correlated with low PS activity in the family. Functional tests revealed that the mutant protein aggregated in the cytoplasm and its secretion and expression decreased. In conclusion, protein S mutation appeared to be the primary cause of @entity1 in the family of the present study. However, the correlation between @entity3 and @entity0 requires further investigation.

title: XXXX leads to @entity0 .

answer: @entity3


abstract: UNASSIGNED: Hereditary protein S (PS) deficiency is an independent risk factor for @entity2 . However, the correlation between PS and arterial @entity1 , such as @entity5 , is not clear. The present study focused on the molecular mechanisms underlying @entity0 caused by a PS gene mutation in one family. The activity of @entity4 , protein  C and PS in the plasma of the proband was measured, and the genes encoding PS were amplified and sequenced. The cellular localization and expression of PS were analyzed in HEK  -293 cells. The proband was a 50  -year  -old male. Plasma PS activity of the proband was 38.9%, which was significantly decreased compared with normal levels. Sequencing analysis revealed a @entity6 @entity7 mutation on exon  12. This frameshift mutation converts Asp496 in the precursor PS into the termination codon. In addition, the @entity6 mutation was correlated with low PS activity in the family. Functional tests revealed that the mutant protein aggregated in the cytoplasm and its secretion and expression decreased. In conclusion, protein S mutation appeared to be the primary cause of @entity1 in the family of the present study. However, the correlation between @entity3 and @entity0 requires further investigation.

title: @entity3 leads to XXXX .

answer: @entity0


abstract: OBJECTIVES: Treatment of central and ultra-central @entity1 with stereotactic ablative radiotherapy (SABR) remains controversial due to risks of treatment-related @entity4 compared with @entity6 . Here we report our institution's experience in treating central and ultra-central @entity1 @entity0 with SABR. MATERIALS AND METHODS: We retrospectively reviewed outcomes in 68 @entity0 with @entity1 , 34 central and 34 peripheral, all treated with SABR consisting of 50Gy in 4-5 fractions. @entity2 centrality was defined per the RTOG 0813 protocol. We defined "ultra-central" @entity2 as those with GTV directly abutting the central airway. RESULTS: Median follow-up time was 18.4months and median overall survival was 38.1 months. Two-year overall survival was similar between ultra-central, central, and peripheral NSCLC (80.0% vs. 63.2% vs. 86.6%, P=0.62), as was 2-year local failure (0% vs. 10.0% vs. 16.3%, P=0.64). @entity4 rates were low and comparable between the three groups, with only two cases of grade 3 @entity4 ( @entity5 ), and one case of grade 4 @entity4 ( @entity3 ) observed. @entity0 with ultra-central @entity2 experienced no symptomatic @entity4 over a median follow-up time of 23.6 months. Dosimetric analysis revealed that RTOG 0813 central airway dose constraints were frequently not achieved in central @entity2 treatment plans, but this did not correlate with increased @entity4 rate. CONCLUSION: @entity0 with central and ultra-central @entity1 treated with SABR (50Gy in 4-5 fractions) experienced few @entity4 and good outcomes, similar to @entity0 with @entity6 .

title: Stereotactic ablative radiotherapy (SABR) for treatment of central and ultra-central XXXX .

answer: @entity1


abstract: BACKGROUND/AIMS: Approximately 20% of @entity0 undergoing surgery for @entity1 will retain their rectum. A single-stage proctocolectomy could be an appropriate procedure in @entity0 who are definitely not candidates for a later restorative procedure, but it is generally not advised in acutely ill @entity0 . The aim was to investigate the safety of one-stage proctocolectomy under elective and non-elective circumstances, with specific reference to identifying possible risk factors for @entity3 . METHODS: A retrospective cohort study, including 54 consecutive @entity0 undergoing proctocolectomy for @entity1 . Out of these, 27 (50%) were admitted non-electively. RESULTS: @entity3 were observed in 30 @entity0 (54%). @entity5 , wound @entity4 , and @entity2 healing were observed in 10 (18.5%), 8 (14.8%), and 10 (18.5%) of the @entity0 , respectively. There was no difference between elective and non-elective cases. Complications were observed more often in @entity0 receiving high-dose corticosteroids (18/26 vs. 12/28; p = 0.06). Impaired perineal wound healing and reoperations were observed more often in the corticosteroid-treated group (8/26 vs. 2/28; p = 0.04 and 12/26 vs. 1/28; p = 0.0003). CONCLUSIONS: Proctocolectomy is equally safe under elective and non-elective situations, but a preoperative treatment with high-dose corticosteroids is associated with an increased risk of complications and reoperations.    2015 S. Karger AG, Basel.

title: Safety of Proctocolectomy for XXXX Under Elective and Non-Elective Circumstances: Preoperative Corticosteroid Treatment Worsens Outcome.

answer: @entity1


abstract: OBJECTIVE: @entity5 is a selective inhibitor of @entity3 oxidase, which is used to manage @entity4 in @entity0 with @entity1 . The objective of the study was to compare the pharmacokinetics of two different strength of @entity5 formulations (80 mg and 40 mg). METHODS: A randomized, single-dose, open-label, two-period, two-sequence crossover study with a 7-day washout period was conducted in 30 healthy male subjects. @entity0 received either reference (1 * 80 mg) or test (2 * 40 mg) formulations during the first period and the alternative formulation during the second period. Plasma samples for the drug analysis were collected up to 24 hours after treatment. RESULTS: All pharmacokinetic parameters were comparable between the two formulations The observed mean Cmax, AUClast, and AUC    values for the reference formulation were 3,670 ng/mL, 12,086 ng*h/mL, and 12,880 ng*h/mL, respectively. Corresponding values for the test formulation were 4,108 ng/mL, 12,689 ng*h/mL, and 13,278 ng*h/mL, respectively. The geometric mean ratios (90% CI) between the two formulations were 1.1273 (1.0286 - 1.2355) for Cmax, 1.054 (1.0115 - 1.0980) for AUClast, and 1.0395 (0.9959 - 1.0851) for AUC   . The changes of serum @entity2 at 24 hours after reference and test formations were comparable (-1.36 mg/dL for reference and -1.37 mg/dL for test; p = 0.892). CONCLUSION: The results of the present study indicated that the reference and test formulations have comparable pharmacokinetics and that these two formulations meet the regulatory criteria for bioequivalence. In addition, the reduction of serum UA levels in the reference formulation was similar to that of the test formulation after a single dose.

title: Comparison of pharmacokinetics and XXXX lowering effect between two different strength febuxostat formulations (80 mg vs. 40 mg) in healthy subjects.

answer: @entity2


abstract: Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans and has been implicated in many important biological processes, including cell differentiation and reprogramming. Germline and somatic mutations in H3.3 genomic incorporation pathway components or in H3.3 encoding genes have been associated with @entity0 @entity3 and @entity1 , respectively. However, the role of H3.3 in @entity0 development remains unclear. To address this question, we generated H3.3-null @entity2 models through classical genetic approaches. We found that H3.3 plays an essential role in @entity2 development. Complete depletion of H3.3 leads to @entity5 and early @entity7 . At the cellular level, @entity2 loss triggers cell cycle suppression and cell death. Surprisingly, H3.3 depletion does not dramatically disrupt gene regulation in the developing embryo. Instead, H3.3 depletion causes dysfunction of heterochromatin structures at telomeres, centromeres, and pericentromeric regions of chromosomes, leading to @entity4 . The resulting karyotypical abnormalities and DNA damage lead to @entity6 pathway activation. In summary, our results reveal that an important function of H3.3 is to support chromosomal heterochromatic structures, thus maintaining genome integrity during @entity0 development.

title: Histone H3.3 maintains genome integrity during XXXX development.

answer: @entity0


abstract: UNASSIGNED: In the present study, antigens from parthenogenetic females and eggs of Strongyloides venezuelensis, or anti-parthenogenetic-female and anti-egg antigens were used to detect specific IgG and immune complex responses, respectively. Serum samples from experimentally infected immunocompetent and immunosuppressed @entity0 were analysed on days 5, 8, 13 and 21 post- @entity1 (dpi). An enzyme-linked immunosorbent assay (ELISA) was performed using alkaline parasite extract for specific IgG detection, and anti-parthenogenetic-female or anti-egg antigens for immune complex detection. The data were analysed using analysis of variance (ANOVA), followed by a Bonferroni test. When parthenogenetic female or egg extracts were used as antigens, specific IgGs were not detected in either immunocompetent or immunosuppressed rats. When anti-parthenogenetic-female or anti-S. venezuelensis-eggs were used, immune complexes were detected for the duration of the @entity1 in immunosuppressed animals and were only detected between 5 and 13 dpi in immunocompetent animals. The duration of @entity1 was not significantly different between the immunocompetent and immunosuppressed groups when anti-parthenogenetic-female or anti-S. venezuelensis-eggs were used. Parthenogenetic female extracts yielded significant differences between antibody and immune complex responses in immunocompetent @entity0 from 5 to 13 dpi, but only on day 5 dpi in immunosuppressed @entity0 . Exposure to @entity3 egg extract yielded significant differences in both antibody and immune complex detection between immunocompetent and immunosuppressed @entity0 for the duration of the @entity1 . In conclusion, ELISA using alternative antigens may be a successful strategy for identifying immune complexes in serum samples and diagnosing active @entity2 , particularly under conditions of immunosuppression.

title: Specific IgG and immune complex responses to parthenogenetic females and eggs of nematode Strongyloides venezuelensis for the diagnosis of immunosuppression in infected XXXX .

answer: @entity0


abstract: UNASSIGNED: The burden of drug resistance emerges in the wake of chronic and repeated antibiotic use. This underpins the importance of discovering alternatives to current antibiotic regimens. In @entity1 ( @entity1 ), topical therapy such as nasal douches and @entity2 sprays is the mainstay of treatment. However, @entity6 such as those with @entity4 biofilm infection point to more recalcitrant @entity1 subtypes, focusing research efforts into topical antimicrobial therapies. In the sinuses, both local mucosal and systemic effects must be considered in designing any new topical medication. @entity5 (NO), an endogenous antimicrobial agent, is found at extremely low levels in @entity1 sinuses and high levels in healthy sinuses. As a novel treatment modality, we have designed a liposomal formulation of an NO donor (LFNO) using @entity7 , as a topical sinus wash in a @entity3 model of @entity4 biofilm rhinosinusitis. Heart rate (HR), blood pressure, mean arterial pressure (MAP), and histologic and ciliary analyses were assessed in the safety component. Efficacy was assessed by quantifying biofilm biomass post-treatment. LFNO-treated @entity3 had lesser @entity0 (P  =  0.02), and comparable ciliary preservation (P  =  0.86) than the control group. A transient increase in HR and decrease in MAP were observed in the LFNO group (P  <  0.05), but this was not accompanied by observable side effects. LFNO @entity3 had significantly lower biofilm biomass vs controls (P  =  0.044). Our findings demonstrate the localized and systemic safety of LFNO in an animal model despite using high NO concentrations, thus warranting further investigation for its possible therapeutic role in @entity1 .

title: An in  vivo safety and efficacy demonstration of a topical liposomal @entity5 donor treatment for XXXX biofilm-associated rhinosinusitis.

answer: @entity4


abstract: UNASSIGNED: The burden of drug resistance emerges in the wake of chronic and repeated antibiotic use. This underpins the importance of discovering alternatives to current antibiotic regimens. In @entity1 ( @entity1 ), topical therapy such as nasal douches and @entity2 sprays is the mainstay of treatment. However, @entity6 such as those with @entity4 biofilm infection point to more recalcitrant @entity1 subtypes, focusing research efforts into topical antimicrobial therapies. In the sinuses, both local mucosal and systemic effects must be considered in designing any new topical medication. @entity5 (NO), an endogenous antimicrobial agent, is found at extremely low levels in @entity1 sinuses and high levels in healthy sinuses. As a novel treatment modality, we have designed a liposomal formulation of an NO donor (LFNO) using @entity7 , as a topical sinus wash in a @entity3 model of @entity4 biofilm rhinosinusitis. Heart rate (HR), blood pressure, mean arterial pressure (MAP), and histologic and ciliary analyses were assessed in the safety component. Efficacy was assessed by quantifying biofilm biomass post-treatment. LFNO-treated @entity3 had lesser @entity0 (P  =  0.02), and comparable ciliary preservation (P  =  0.86) than the control group. A transient increase in HR and decrease in MAP were observed in the LFNO group (P  <  0.05), but this was not accompanied by observable side effects. LFNO @entity3 had significantly lower biofilm biomass vs controls (P  =  0.044). Our findings demonstrate the localized and systemic safety of LFNO in an animal model despite using high NO concentrations, thus warranting further investigation for its possible therapeutic role in @entity1 .

title: An in  vivo safety and efficacy demonstration of a topical liposomal XXXX donor treatment for @entity4 biofilm-associated rhinosinusitis.

answer: @entity5


abstract: UNASSIGNED: The 21-Gene Recurrence Score Assay has been intensively studied and recommended by major guidelines for treatment decision in early @entity0 . Its impact in adjuvant chemotherapy selection for Chinese population has not been revealed.The prospective part of this study enrolled consecutive node-negative, @entity3 -positive @entity1 who underwent 21-gene RS testing at Breast Surgery Department of PUMCH (n=134) between May 2012 and August 2013(21-gene RS group). Risk categories were assigned based on the RS and on standard clinicopathologic criteria according to St. Gallen and Adjuvant! Online. The chemotherapy selection and the oncologists' confidence in decision-making before and after RS testing were recorded. The retrospective part of this study compared the chemotherapy decision in the 21-gene RS group and a  control group without RS testing (diagnosed between Jan 2011 and Apr 2012,n=170). A total of 304 @entity1 were included in the analysis (134 21-gene RS group, 170 controls). Based on RS, 97 @entity1 were classified as low risk, 29 @entity1 as intermediate risk, and 8 @entity1 as high risk. @entity2 grade (P=0.002), PR expression (P<0.001) and Ki-67 index (P<0.001) were significantly different between the 3 risk cohorts.Comparing the St. Gallen guidelines and RS, there was a  41% concordance between risk groups. By using Adjuvant! Online, the correlation between the predicted BCSM and RS was nominal (r=0.10). A  total of 29% 21-gene RS group @entity1 changed their treatment decisions after RS testing (P<0.001, 95% CI, 0.18 to 0.49) with 6% (8/134) @entity1 changing to receive chemotherapy besides endocrine therapy and 23% (31/134) changing to reject chemotherapy. After RS testing, more than one half of the oncologists increased their confidence level in treatment recommendation. In the control group, 67.6% (115/170) @entity1 chose chemotherapy plus endocrine therapy. The chemotherapy percentage was much higher than that of 21-gene RS group (30/134, 22%).This is the first study to demonstrate a  reduction in the use of adjuvant chemotherapy in @entity1 with node-negative @entity3 -positive @entity0 , based on use of the RS. The RS had an impact on the physicians' treatment decision-making.

title: Impact of the 21-Gene Recurrence Score Assay in adjuvant chemotherapy selection for node-negative, @entity3 -positive XXXX in the Chinese population.

answer: @entity0


abstract: UNASSIGNED: The 21-Gene Recurrence Score Assay has been intensively studied and recommended by major guidelines for treatment decision in early @entity0 . Its impact in adjuvant chemotherapy selection for Chinese population has not been revealed.The prospective part of this study enrolled consecutive node-negative, @entity3 -positive @entity1 who underwent 21-gene RS testing at Breast Surgery Department of PUMCH (n=134) between May 2012 and August 2013(21-gene RS group). Risk categories were assigned based on the RS and on standard clinicopathologic criteria according to St. Gallen and Adjuvant! Online. The chemotherapy selection and the oncologists' confidence in decision-making before and after RS testing were recorded. The retrospective part of this study compared the chemotherapy decision in the 21-gene RS group and a  control group without RS testing (diagnosed between Jan 2011 and Apr 2012,n=170). A total of 304 @entity1 were included in the analysis (134 21-gene RS group, 170 controls). Based on RS, 97 @entity1 were classified as low risk, 29 @entity1 as intermediate risk, and 8 @entity1 as high risk. @entity2 grade (P=0.002), PR expression (P<0.001) and Ki-67 index (P<0.001) were significantly different between the 3 risk cohorts.Comparing the St. Gallen guidelines and RS, there was a  41% concordance between risk groups. By using Adjuvant! Online, the correlation between the predicted BCSM and RS was nominal (r=0.10). A  total of 29% 21-gene RS group @entity1 changed their treatment decisions after RS testing (P<0.001, 95% CI, 0.18 to 0.49) with 6% (8/134) @entity1 changing to receive chemotherapy besides endocrine therapy and 23% (31/134) changing to reject chemotherapy. After RS testing, more than one half of the oncologists increased their confidence level in treatment recommendation. In the control group, 67.6% (115/170) @entity1 chose chemotherapy plus endocrine therapy. The chemotherapy percentage was much higher than that of 21-gene RS group (30/134, 22%).This is the first study to demonstrate a  reduction in the use of adjuvant chemotherapy in @entity1 with node-negative @entity3 -positive @entity0 , based on use of the RS. The RS had an impact on the physicians' treatment decision-making.

title: Impact of the 21-Gene Recurrence Score Assay in adjuvant chemotherapy selection for node-negative, XXXX -positive @entity0 in the Chinese population.

answer: @entity3


abstract: BACKGROUND: (1) To characterize the @entity2 ( @entity2 ) of @entity1 individuals with @entity0 and (2) to determine the contribution of @entity2 to the independence in basic and instrumental activities of daily living (BADL and IADL) and the participation of individuals with @entity0 . @entity2 is the confidence in one's own ability to perform self-care activities. METHODS: This cross-sectional study included fifty community-dwelling individuals mean (SD) age 59.8 (9.3) years, mean (SD) 3.1 (1.7) years post- @entity0 who were able to walk at least 10 meters. @entity2 was assessed using the Stroke Self-Efficacy Questionnaire (SSEQ), BADL was assessed by the Functional Independence Measure (FIM) (interview), the IADL questionnaire assessed IADL and the Physical Activity Scale for Individuals with Physical Disabilities (PASIPD) assessed participation. Correlation and regression analyses were performed after controlling for grip strength, executive functions and gait speed, factors known to influence independence in daily living. RESULTS: The mean @entity2 level was moderate-high (70%). Significant moderate correlations were found between @entity2 to independence in BADL (r = .596, P < .001), IADL (r = .567, P < .001) and participation (r = .340, P < .005). @entity2 of our cohort explained 7.4% of the variance of the individual's independence in BADL after controlling for executive functions and gait speed, but did not contribute to their independence in IADL and participation. CONCLUSIONS: Higher @entity2 of individuals  with @entity0 contributes to more independence in BADL. Additional questionnaires regarding self efficacy for IADL should be developed and investigated.

title: Self-Care Self-Efficacy Correlates with Independence in Basic Activities of Daily Living in Individuals with XXXX .

answer: @entity0


abstract: Thirty-eight cutaneous lesions previously diagnosed as spindle cell @entity5 , " @entity6 ," or dermal @entity3 are presented. Two @entity0 had two lesions each; thus, there were 36 @entity0 . Cases of @entity4 (including @entity4 ), @entity3 of subcutaneous origin, and " @entity3 " were excluded. On review, the lesions fell into two categories: (1) those with a definite component of invasive @entity5 in addition to @entity3 -like areas (8 cases), and (2) those in which such a squamous component was not identified (30 cases). Cases in the former group were considered proven spindle cell @entity5 , while those in the latter group were designated noncommittally as @entity1 . Almost all @entity0 were white and over 40 years of age. Four @entity1 (from three @entity0 ) arose in areas previously treated with x-ray and all but two (both spindle cell @entity5 ) of the remainder in both categories arose in sun-damaged skin. Prognosis did not differ significantly between the two categories but depended primarily on the depth of invasion. Two of two @entity1 that extended into bone and four of seven that invaded skeletal muscle caused @entity2 ; all of those involving only dermis (24) or dermis and subcutis (five) were successfully extirpated. Origin in an area that had received x-ray was also an unfavorable prognostic indicator; all three @entity0 whose lesions arose in such areas died of @entity1 . This may have been related to depth of invasion because the three fatal @entity1 all invaded muscle. It was concluded that the distinction between spindle cell @entity5 and "atyical fibroxanthoma" is of little prognostic import per se, but rather that prognosis is primarily dependent on the depth of invasion and, perhaps, the type of antecedent irradiation.

title: Spindle cell XXXX and @entity1 of the skin: a comparative study of 38 cases.

answer: @entity5


abstract: Thirty-eight cutaneous lesions previously diagnosed as spindle cell @entity5 , " @entity6 ," or dermal @entity3 are presented. Two @entity0 had two lesions each; thus, there were 36 @entity0 . Cases of @entity4 (including @entity4 ), @entity3 of subcutaneous origin, and " @entity3 " were excluded. On review, the lesions fell into two categories: (1) those with a definite component of invasive @entity5 in addition to @entity3 -like areas (8 cases), and (2) those in which such a squamous component was not identified (30 cases). Cases in the former group were considered proven spindle cell @entity5 , while those in the latter group were designated noncommittally as @entity1 . Almost all @entity0 were white and over 40 years of age. Four @entity1 (from three @entity0 ) arose in areas previously treated with x-ray and all but two (both spindle cell @entity5 ) of the remainder in both categories arose in sun-damaged skin. Prognosis did not differ significantly between the two categories but depended primarily on the depth of invasion. Two of two @entity1 that extended into bone and four of seven that invaded skeletal muscle caused @entity2 ; all of those involving only dermis (24) or dermis and subcutis (five) were successfully extirpated. Origin in an area that had received x-ray was also an unfavorable prognostic indicator; all three @entity0 whose lesions arose in such areas died of @entity1 . This may have been related to depth of invasion because the three fatal @entity1 all invaded muscle. It was concluded that the distinction between spindle cell @entity5 and "atyical fibroxanthoma" is of little prognostic import per se, but rather that prognosis is primarily dependent on the depth of invasion and, perhaps, the type of antecedent irradiation.

title: Spindle cell @entity5 and XXXX of the skin: a comparative study of 38 cases.

answer: @entity1


abstract: OBJECTIVE: Reduced pulmonary function is an important predictor of environment-related @entity1 ; however, evidence of an association between exposures to various metals from all possible routes and altered pulmonary function is limited. We aimed to investigate the association of various metals in urine with pulmonary function, @entity1 ( @entity1 ) and @entity3 ( @entity3 ) risks in the general Chinese population. DESIGN: A cross-sectional investigation in the Wuhan cohort population. SETTING: A heavily polluted Chinese city. @entity0 : A total of 2460 community-living Chinese adults from the Wuhan cohort were included in our analysis. MAIN OUTCOME MEASURES: Spirometric parameters (FVC, forced vital capacity; FEV1, forced expiratory volumes in 1   s; FEV1/FVC ratio), @entity1 and @entity3 . RESULTS: The dose-response associations of pulmonary function, and @entity1 and @entity3 , with 23 urinary metals were assessed using regression analysis after adjusting for potential confounders. The false discovery rate (FDR) method was used to correct for multiple hypothesis tests. Our results indicated that there were positive dose-response associations of urinary iron with FEV1 and FEV1/FVC ratio, vanadium with FEV1, and copper and selenium with FEV1/FVC ratio, while a negative dose-response association was observed between urinary lead and FEV1/FVC ratio (all p<0.05). After additional adjusting for multiple comparisons, only iron was dose dependently related to FEV1/FVC ratio (FDR adjusted p<0.05). The dose-response association of iron and lead, with decreased and increased @entity2 risk, respectively, was also observed (both p<0.05). Additionally, we found significant association of urinary zinc with @entity1 and interaction effects of smoking status with lead on FEV1/FVC, and with cadmium on FVC and FEV1. CONCLUSIONS: These results suggest that multiple urinary metals are associated with altered pulmonary function, and @entity1 and @entity3 prevalences.

title: The dose-response association of urinary metals with altered pulmonary function and risks of XXXX : a population-based study in China.

answer: @entity3


abstract: UNASSIGNED: Immunity to non-cerebral severe @entity4 is estimated to occur within 1-2 infections in areas of endemic transmission for @entity9 . Yet, nearly 20% of infected @entity0 die annually as a result of severe @entity4 . Multiple risk factors are postulated to exacerbate @entity2 , one being @entity5 with other pathogens. @entity0 living in Sub-Saharan Africa are seropositive for @entity10 ) by the age of 6 months. This timing overlaps with the waning of protective maternal antibodies and susceptibility to primary @entity9 @entity3 . However, the impact of acute @entity8 on the generation of anti-malarial immunity is unknown. Using well established @entity1 models of @entity3 , we show here that acute, but not latent @entity11 (MHV68) @entity3 suppresses the anti-malarial humoral response to a secondary @entity3 . Importantly, this resulted in the transformation of a non-lethal @entity6 XNL @entity3 into a lethal one; an outcome that is correlated with a defect in the maintenance of germinal center B cells and T follicular helper (Tfh) cells in the spleen. Furthermore, we have identified the MHV68 M2 protein as an important virus encoded protein that can: (i) suppress anti-MHV68 humoral responses during acute MHV68 @entity3 ; and (ii) plays a critical role in the observed suppression of anti-malarial humoral responses in the setting of @entity5 . Notably, @entity5 with an M2-null mutant MHV68 eliminates lethality of @entity6 XNL. Collectively, our data demonstrates that an acute gammaherpesvirus @entity3 can negatively impact the development of an anti-malarial immune response. This suggests that @entity7 with EBV should be investigated as a risk factor for non-cerebral severe @entity4 in young @entity0 living in areas endemic for @entity9 transmission.

title: Gammaherpesvirus XXXX with @entity4 Suppresses Anti-parasitic Humoral Immunity.

answer: @entity5


abstract: UNASSIGNED: Immunity to non-cerebral severe @entity4 is estimated to occur within 1-2 infections in areas of endemic transmission for @entity9 . Yet, nearly 20% of infected @entity0 die annually as a result of severe @entity4 . Multiple risk factors are postulated to exacerbate @entity2 , one being @entity5 with other pathogens. @entity0 living in Sub-Saharan Africa are seropositive for @entity10 ) by the age of 6 months. This timing overlaps with the waning of protective maternal antibodies and susceptibility to primary @entity9 @entity3 . However, the impact of acute @entity8 on the generation of anti-malarial immunity is unknown. Using well established @entity1 models of @entity3 , we show here that acute, but not latent @entity11 (MHV68) @entity3 suppresses the anti-malarial humoral response to a secondary @entity3 . Importantly, this resulted in the transformation of a non-lethal @entity6 XNL @entity3 into a lethal one; an outcome that is correlated with a defect in the maintenance of germinal center B cells and T follicular helper (Tfh) cells in the spleen. Furthermore, we have identified the MHV68 M2 protein as an important virus encoded protein that can: (i) suppress anti-MHV68 humoral responses during acute MHV68 @entity3 ; and (ii) plays a critical role in the observed suppression of anti-malarial humoral responses in the setting of @entity5 . Notably, @entity5 with an M2-null mutant MHV68 eliminates lethality of @entity6 XNL. Collectively, our data demonstrates that an acute gammaherpesvirus @entity3 can negatively impact the development of an anti-malarial immune response. This suggests that @entity7 with EBV should be investigated as a risk factor for non-cerebral severe @entity4 in young @entity0 living in areas endemic for @entity9 transmission.

title: Gammaherpesvirus @entity5 with XXXX Suppresses Anti-parasitic Humoral Immunity.

answer: @entity4


abstract: UNASSIGNED: @entity10 ( @entity10 ) is a devastating complication of aortic operations. Neuromonitoring using @entity8 ( @entity8 ) is a sensitive modality to detect @entity10 in @entity0 . We describe a leporine @entity10 model using @entity8 to test pharmaceutical therapeutics and other neuroprotective adjuncts. In 80 @entity3 , methods to obtain @entity8 in normotensive and @entity1 @entity3 were developed. The effects of @entity11 , @entity7 , @entity4 , and @entity6 on lower extremity @entity8 were studied. Lower extremity @entity8 disappear upon @entity10 induction in 78 of 78 (100  %) @entity3 . Prior to @entity10 induction and during @entity9 , lower extremity @entity8 were lost in all (100  %) and upper extremity @entity8 in one (25  %). @entity11 was used in four experiments, with loss of lower extremity @entity8 in all four (100  %) and loss of upper extremity @entity8 in zero. With @entity7 upper extremity, @entity8 were obtainable in 80 of 80 @entity3 (100  %) and lower extremity @entity8 in 78 of 80 @entity3 (97.5  %) prior to @entity10 induction. The presence of these lower extremity @entity8 prior to @entity10 induction was not correlated with @entity6 . Disappearance of @entity8 occurred in all 45 @entity3 with @entity2 . @entity8 in the leporine model correlate closely with @entity5 . @entity8 are influenced by inhaled anesthetics and @entity4 but not by @entity6 alone. @entity7 anesthesia provides reliable @entity8 . This study provides the basis for a reproducible model of @entity10 to be used for novel therapeutic drug development.

title: Methodology of Motor Evoked Potentials in a XXXX Model.

answer: @entity3


abstract: PURPOSE: To assess the impact of increasing dose on @entity4 ( @entity4 ) for @entity2 @entity0 . METHODS: Treatment data were obtained on more than 20,000 @entity0 in the National Oncology Data Alliance  , a proprietary database of merged @entity1 registries, who were treated for @entity2 with definitive radiotherapy between 1995 and 2006. Eligible @entity0 had complete data on total dose, T stage, use and timing of @entity3 deprivation therapy (ADT), and treatment start date (n   =   20,028). @entity0 with prior @entity1 were excluded. RESULTS: On multivariate analysis, dose, T stage, grade, marital status, age, and neoadjuvant ADT were significant predictors of @entity4 . Hazard ratios for @entity4 declined monotonically with increasing dose, reaching 0.63 (95  % Confidence Interval 0.53-0.76) at >= 80  Gy. On subset analysis, neoadjuvant ADT significantly improved @entity4 in high risk @entity0 but was not significant in lower risk @entity0 . The dose response was maintained across all risk groups. Medical comorbidities were balanced across all dose strata and sensitivity analysis demonstrated that other prognostic factors were unlikely to explain the observed dose response. CONCLUSIONS: This study suggests that increasing dose significantly improves @entity4 in @entity2 @entity0 treated with radiotherapy.

title: The impact of increasing dose on @entity4 in XXXX .

answer: @entity2


abstract: PURPOSE: To assess the impact of increasing dose on @entity4 ( @entity4 ) for @entity2 @entity0 . METHODS: Treatment data were obtained on more than 20,000 @entity0 in the National Oncology Data Alliance  , a proprietary database of merged @entity1 registries, who were treated for @entity2 with definitive radiotherapy between 1995 and 2006. Eligible @entity0 had complete data on total dose, T stage, use and timing of @entity3 deprivation therapy (ADT), and treatment start date (n   =   20,028). @entity0 with prior @entity1 were excluded. RESULTS: On multivariate analysis, dose, T stage, grade, marital status, age, and neoadjuvant ADT were significant predictors of @entity4 . Hazard ratios for @entity4 declined monotonically with increasing dose, reaching 0.63 (95  % Confidence Interval 0.53-0.76) at >= 80  Gy. On subset analysis, neoadjuvant ADT significantly improved @entity4 in high risk @entity0 but was not significant in lower risk @entity0 . The dose response was maintained across all risk groups. Medical comorbidities were balanced across all dose strata and sensitivity analysis demonstrated that other prognostic factors were unlikely to explain the observed dose response. CONCLUSIONS: This study suggests that increasing dose significantly improves @entity4 in @entity2 @entity0 treated with radiotherapy.

title: The impact of increasing dose on XXXX in @entity2 .

answer: @entity4


abstract: AIM: To describe the prevalence and characteristics of @entity3 ( @entity3 ) in @entity0 with underlying @entity4 , and to compare it by three different measures. METHODS: We studied 546 @entity0 with chronic @entity4 who attended our rheumatology clinic. If @entity0 answered all of a screening questionnaire with yes, then we considered @entity0 to be having @entity2 as assessed by the @entity3 impact questionnaire (FIQ), @entity2 index (WPI), and @entity1 ( @entity1 ). A physician administered the tender point (TP) exam and clinician's judgment of @entity3 . We collected demographics, clinical and laboratory features. RESULTS: One hundred and sixty-four (30.0%) @entity0 among 546 cases had a further exam. The male-to-female count was 25  :  139. The mean age was 49.7  years, disease duration 3.7  years, TP counts 4.2, FIQ score 47.0 and WPI with @entity1 score was 11.1. We classified 17 @entity0 (10.4%) with concomitant @entity3 with @entity2 by tender point exam, 56 @entity0 (34.2%) by WPI with @entity1 , and 36 @entity0 (22.0%) by a clinician's judgment. A total of 70.6% (n  =  12) of those classified as @entity3 by 1990 American College of Rheumatology (ACR) criteria wee categorized as @entity3 by clinician's judgment, while 33.3% by clinician's judgment were classified by 1990 ACR criteria. CONCLUSIONS: We found a 10.4~34.2% prevalence of concomitant @entity3 in the @entity0 with chronic @entity2 . The 1990 ACR criteria were the most restrictive except for @entity5 . Although The 2010 ACR criteria had a wide spectrum, it can be used for @entity3 diagnosis even in the @entity0 with underlying @entity4 .

title: XXXX with chronic @entity4 in South Korea: a comparison of clinical and American College of Rheumatology criteria.

answer: @entity3


abstract: AIM: To describe the prevalence and characteristics of @entity3 ( @entity3 ) in @entity0 with underlying @entity4 , and to compare it by three different measures. METHODS: We studied 546 @entity0 with chronic @entity4 who attended our rheumatology clinic. If @entity0 answered all of a screening questionnaire with yes, then we considered @entity0 to be having @entity2 as assessed by the @entity3 impact questionnaire (FIQ), @entity2 index (WPI), and @entity1 ( @entity1 ). A physician administered the tender point (TP) exam and clinician's judgment of @entity3 . We collected demographics, clinical and laboratory features. RESULTS: One hundred and sixty-four (30.0%) @entity0 among 546 cases had a further exam. The male-to-female count was 25  :  139. The mean age was 49.7  years, disease duration 3.7  years, TP counts 4.2, FIQ score 47.0 and WPI with @entity1 score was 11.1. We classified 17 @entity0 (10.4%) with concomitant @entity3 with @entity2 by tender point exam, 56 @entity0 (34.2%) by WPI with @entity1 , and 36 @entity0 (22.0%) by a clinician's judgment. A total of 70.6% (n  =  12) of those classified as @entity3 by 1990 American College of Rheumatology (ACR) criteria wee categorized as @entity3 by clinician's judgment, while 33.3% by clinician's judgment were classified by 1990 ACR criteria. CONCLUSIONS: We found a 10.4~34.2% prevalence of concomitant @entity3 in the @entity0 with chronic @entity2 . The 1990 ACR criteria were the most restrictive except for @entity5 . Although The 2010 ACR criteria had a wide spectrum, it can be used for @entity3 diagnosis even in the @entity0 with underlying @entity4 .

title: @entity3 with chronic XXXX in South Korea: a comparison of clinical and American College of Rheumatology criteria.

answer: @entity4


abstract: Electrophysiologic studies of His' bundle were done on 32 consecutive @entity0 with symptomatic @entity2 . Nineteen had pure @entity1 and 13 had @entity4 , four with significant regurgitation. Fifteen of the former had atrioventricular (AV) and/or intraventricular (IV) @entity5 . In those with @entity4 , eight had @entity5 , all intraventricular but one. Twelve of the 13 with @entity4 had radiographically indentifiable @entity9 ; all four with a peak systolic gradient greater than 80 mm Hg had @entity8 . Of the 32 @entity0 , six had A-H prolongation and in all the predominant lesion was @entity1 (one with moderate @entity7 ). There was no difference in age, clinical @entity6 , @entity3 , or prolonged H-V interval. However, PR prolongation (P = .01) and decreased ejection fraction (P = .02) was significantly increased in the former group. @entity0 with @entity1 had longer A-H and H-V intervals (NS), induced @entity5 at lower heart rates (P = .01), and higher A-V node effective (P = .001) and functional (P = .01) refractory periods. In summary, @entity0 with @entity2 have a high incidence of atrioventricular and intraventricular conduction disease.

title: Atrioventricular and intraventricular conduction disturbances in XXXX .

answer: @entity2


abstract: BACKGROUND: We assessed the effectiveness of perioperative MAGIC-style chemotherapy in our series focused on the @entity1 regression grade and survival rate. METHODS: We conducted a retrospective study of 53 @entity0 following a perioperative regimen of epirubicin, cisplatin, and fluorouracil or capecitabine (ECF/X). Forty-four (83  %) @entity1 were located in the stomach and 9 (17  %) were located at the esophagogastric junction. Perioperative chemotherapy completion, resection, TNM staging, the @entity1 regression grade (Becker's classification) and survival were analyzed. RESULTS: Forty-five @entity0 (85  %) completed the 3 preoperative cycles. R0 resection was achieved in 42 (79  %) @entity0 . Thirty-five (66  %) @entity0 completed the 3 postoperative cycles. Nine @entity2 (17  %) were considered major responders after preoperative chemotherapy. With multivariate analysis, only completion of perioperative chemotherapy (HR: 0.25; 95%CI: 0.08 - 0.79; p   =   0.019) was identified as an independent prognostic factor for disease-specific survival. However, the protective effect of perioperative therapy was lost in @entity0 with ypT3-4 and more than 4 positive lymph nodes (HR: 1.16; 95%CI: 1.02 - 1.32; p   =   0.029). The @entity1 regression grade (major vs minor responders) was at the limit of significance only with univariate analysis. The 5-year overall and disease-specific survival rates were 18  % and 22  % respectively. CONCLUSIONS: The percentage of major responder @entity1 after preoperative chemotherapy was low. Completion of perioperative ECF/X chemotherapy may benefit @entity0 with @entity3 that do not invade the subserosa with few positive lymph nodes.

title: Tumor regression and survival after perioperative MAGIC-style chemotherapy in XXXX and gastroesophageal junction.

answer: @entity2


abstract: BACKGROUND: Urothelial @entity2 is a highly heterogeneous disease. @entity0 cell lines are useful tools for its study. This is a comprehensive genomic characterization of 40 urothelial @entity2 (UBC) cell lines including information on origin, mutation status of genes implicated in @entity2 ( @entity4 , @entity6 , @entity3 , and RAS), copy number alterations assessed using high density SNP arrays, @entity5 ( @entity5 ) events, and gene expression. RESULTS: Based on gene mutation patterns and genomic changes we identify lines representative of the @entity4 -driven @entity0 pathway and of the @entity3 /RB @entity0 suppressor-driven pathway. High-density array copy number analysis identified significant focal gains (1q32, 5p13.1-12, 7q11, and 7q33) and losses (i.e. 6p22.1) in regions altered in @entity0 but not previously described as affected in bladder cell lines. We also identify new evidence for frequent regions of @entity5 , often coinciding with regions reported to be lost in @entity0 . Previously undescribed chromosome X losses found in UBC lines also point to potential @entity0 suppressor genes. Cell lines representative of the @entity4 -driven pathway showed a lower number of @entity5 events. CONCLUSIONS: Overall, there is a predominance of more @entity1 subtypes among the cell lines. We provide a cell line classification that establishes their relatedness to the major molecularly-defined @entity2 subtypes. The compiled information should serve as a useful reference to the @entity2 research community and should help to select cell lines appropriate for the functional analysis of @entity2 genes, for example those being identified through massive parallel sequencing.

title: The UBC-40 Urothelial Bladder XXXX cell line index: a genomic resource for functional studies.

answer: @entity0


abstract: Based on the experience of a Short Term Scientific Mission (STSM) promoted by COST Net and developed in CIES/ISCTE-IUL (Portugal), this paper presents a reflection about the implementation of @entity1 ( @entity1 ) in the healthcare sector in Israel and Portugal. Specifically, we focus on the impacts of @entity1 or eHealth on @entity0 empowerment, as perceived by doctors and managers in order to better comprehend the role of national policy and explore the options for building a national strategy regarding @entity1 in healthcare. The experience of the Portuguese healthcare system was selected and compared to the results found in a similar research in Israel. Methodologically, in-depth interviews with the Ministry of Health, the private sector, @entity0 associations and researches were used to collect data. Purposeful sampling was used to select respondents, and secondary sources were used for triangulation. The findings of the research work show that the increased deployment of @entity1 has furthered @entity0 empowerment (1). From the doctors' perspective, while @entity1 has provided more information in the long-run, changes of these magnitudes were not easy in the beginning. These findings were similar in both countries. The work concludes that @entity1 tools were successfully implemented and the general perception is that they have been beneficial. The work provides information in order to understand and improve @entity1 services. Additionally, the results suggest alternatives for future investments in these technologies.

title: The Impact of eHealth and mHealth on doctor behavior and XXXX involvement: an Israeli and Portuguese comparative approach.

answer: @entity0


abstract: OBJECTIVES: The aim of our study was to determine the diagnostic value of a novel image analysis method called parametric response mapping (PRM) for prediction of intrahepatic recurrence of @entity2 ( @entity2 ) treated with conventional transcatheter arterial chemoembolization (TACE). METHODS: This retrospective study was approved by the IRB. We recruited 55 @entity2 @entity0 who achieved complete remission (CR) after TACE and received longitudinal multiphasic liver computed tomography (CT). The @entity0 fell into two groups: the recurrent @entity1 group (n   =   29) and the non-recurrent @entity1 group (n   =   26). We applied the PRM analysis to see if this technique could distinguish between the two groups. The results of the PRM analysis were incorporated into a prediction algorithm. We retrospectively removed data from the last time point and attempted to predict the response to therapy of the removed data. RESULTS: The PRM analysis was able to distinguish between the non-recurrent and recurrent groups successfully. The prediction algorithm detected response to therapy with an area under the curve (AUC) of 0.76, while the manual approach had AUC 0.64. CONCLUSIONS: Adopting PRM analysis can potentially distinguish between recurrent and non-recurrent HCCs and allow for prediction of response to therapy after TACE. KEY POINTS:     Parametric response mapping (PRM) could help assess @entity0 with recurrent HCCs after TACE.     Parametric response mapping could direct @entity0 to individualized therapy.     Longitudinal CT images were analyzed with advanced image analysis method.

title: Parametric response mapping of dynamic CT for predicting intrahepatic recurrence of XXXX after conventional transcatheter arterial chemoembolization.

answer: @entity2


abstract: UNASSIGNED: @entity1 is an incapacitating condition commonly affecting cochlear implant (CI) candidates. The aim of this clinical study is to assess the long-term effects of CI treatment in @entity0 with severe-to-profound, sensorineural, @entity2 ( @entity2 ) and incapacitating @entity1 . We performed a prospective Cochlear    company-sponsored multicentre study in five Spanish centres. Sixteen @entity0 with @entity2 and incapacitating @entity1 , which was indicated by a @entity3 Inventory (THI) score >58%, received a Nucleus   CI in their deaf ear. The study design includes repeated within-subject measures on hearing, @entity1 , @entity6 and quality of life up to 12 months after initial CI fitting. In addition to @entity2 and @entity1 , all @entity0 suffered from @entity6 . Most @entity0 had a @entity5 and received a CI within 2 years after their @entity2 . Preliminary 6-month, post-CI activation data of 13 subjects showed that the majority of @entity0 perceived a subjective benefit from CI treatment, which was assessed using the THI, a Visual Analogue Scale of @entity1 loudness/annoyance and the Speech, Spatial and Qualities of Hearing Scale. Preliminary 12-month data of 7 subjects showed that most @entity0 also perceived a degree of relief from their @entity6 . One @entity0 showed no improvements in any of the applied scales, which could be explained by partial insertion of the electrode due to obstruction of the cochlea by @entity7 . In conclusion, CI can successfully be used in the treatment of @entity2 @entity0 with accompanying severe @entity1 and @entity6 . Implantation resulted in hearing benefits and a durable relief from @entity1 and @entity6 in the majority of @entity0 . These findings support the hypothesis that pathophysiological mechanisms after peripheral @entity4 are at least partly reversible when hearing is restored with a CI.    2015 S. Karger AG, Basel.

title: Cochlear Implants as a Treatment Option for Unilateral Hearing Loss, Severe XXXX and @entity6 .

answer: @entity1