abstract: Percutaneous mechanical thrombectomy (PMT) has been gaining acceptance as a preferred approach for the treatment of @entity4 ( @entity4 ). In addition to treating acute @entity4 and decreasing the risk of @entity5 , it has been reported that direct extraction of the @entity2 decreases the risk of @entity2 ( @entity2 ), the economic impact of managing which is reported to account for 75% of the total cost of management of @entity4 @entity0 . PMT combines localized thrombolysis with mechanical thrombectomy. Recently, there have been some reports of reversible @entity3 ( @entity3 ) occurring post-PMT. The pathophysiology of @entity3 in such cases is due to @entity8 -associated @entity7 . Therefore, the overall prognosis of @entity3 post-PMT has been reported to be good. We report here a case of @entity3 post-PMT for an extensive @entity4 of the lower extremity whereby the @entity0 continues to require @entity6 even 5 months after the procedure. The @entity0 had normal renal function prior to the procedure and evidence of @entity8 at the time of diagnosis of @entity3 . Our case illustrates that @entity0 with a large @entity2 load may develop severe @entity3 post-PMT thus requiring hemodialysis for an extended period of time. Limiting the length of time that the mechanical thrombectomy is performed and quantifying the amount of effluent obtained would appear to be a prudent practice to reduce the risks of @entity1 . However, no specific guidelines exist as for the limits of hemolysed exudates to be collected.

title: XXXX post-percutaneous mechanical thrombectomy.

answer: @entity1


abstract: INTRODUCTION: Needle-knife sphincterotomy (NKS), known as 'precut', is used worldwide to facilitate access to the common bile duct when standard cannulation has failed. This procedure is considered hazardous because it is burdened with high procedural related complications ( @entity1 and perforation). Its right timing is still debated. In this study we report our results using a modified precut approach, early shallow needle-knife papillotomy (eSNKP) coupled with guidewire cannulation in case of @entity3 . We evaluated its safety and effectiveness. METHODS: From 2012 to 2014, 1034 @entity0 underwent therapeutic ERCP. A total of 138 of them presented @entity3 and were treated with eSNKP performed after 5 failed attempts of standard guidewire cannulation. Deep biliary cannulation rate was recorded, as well as intraoperative and postoperative complication rate. RESULTS: Successful biliary deep cannulation was achieved in 132/138 @entity0 (95.7%) by means of eSNKP. In 6 @entity0 (4.3%), cannulation failed even after eSNKP. ERCP was newly performed 72 hours later with successful and immediate guidewire biliary cannulation. Overall morbidity was 10.1% (14/138). No perforation occurred. @entity1 occurred in 4/138 cases (2.9%) and 10/138 @entity0 (7.2%) developed mild @entity2 . CONCLUSION: In case of @entity3 , eSNKP followed by guidewire cannulation increases the successful deep biliary cannulation with low rate of complications.

title: Early 'shallow' needle-knife papillotomy and guidewire cannulation: an effective and safe approach to XXXX .

answer: @entity3


abstract: OBJECTIVE: To determine the outcomes of @entity12 in school-age survivors. DESIGN: Prospective cohort study. SETTING: Teaching pediatric hospital. @entity0 : During 1983 through 1986, 158 @entity7 survivors, ages 3 months to 14 years, treated at a single center were enrolled. Between 1991 and 1993, 130 @entity0 , 82% of the original cohort, were evaluated at a mean age of 8.4 years and a mean of 6.7 years after their @entity7 . OUTCOME MEASURES: Blinded neurologic, neuropsychologic, audiologic, behavior, and socio-demographic assessments were compared with those from grade- and sex-matched control @entity0 . Multivariate analyses adjusted for age at testing and socio-demographic variables. RESULTS: There was a systematic increase in risk of abnormality or poorer functioning for @entity0 with @entity7 , compared with control @entity0 , across all categories tested, which was significant for fine motor function, Intelligence quotient (IQ) scores, and tests of school behavior, neuropsychologic function, and auditory figure-ground differentiation. Eleven @entity0 who had experienced @entity7 (8.5%) had @entity2 (IQ < 70, @entity5 , @entity8 , @entity6 , @entity10 , or severe to profound @entity4 ); a further 24 (18.5%) cases and 14 (10.8%) control @entity0 had minor deficits (IQ 70 to 80, inability to read, mild to moderate @entity4 , @entity9 , or school behavior problems). Overall, @entity0 who had @entity7 were at greater risk (26.9%) for disability. @entity0 with @entity1 had more adverse outcomes than those with uncomplicated @entity7 and control @entity0 (39% vs 18% vs 11%, respectively). CONCLUSIONS: One in four school-age @entity7 survivors has either serious and disabling sequelae or a functionally important @entity3 , @entity11 adversely affecting academic performance. As a group, survivors function less well than their classroom peers, and risk is greatest for, but not confined to, those who had @entity1 . All survivors require careful follow-up, at least until school age.

title: Adverse outcomes of XXXX in school-age survivors.

answer: @entity12


abstract: The effect of intravenous therapy with iloprost (average duration 6 weeks) on the prognosis of leg-preserving local surgical treatment and on the transcutaneously measured @entity1 pressure (tcPO2) in @entity0 with @entity2 was investigated in a prospective, open, controlled, randomized study. All of the 30 @entity0 recruited to the study suffered from a peripheral @entity3 Fontaine stage IV with progressive symptoms and @entity3 below the knee. 15 @entity0 received iloprost intravenously for 6 hours per day in an individual tolerable dose (mean dose: 1.7 ng/kg/min). 15 @entity0 in the control group received no trial therapy. During the treatment period each @entity0 underwent minor amputation or skin grafting. Wound healing after surgery and tcPO2 were assessed. The long-term efficacy of iloprost was assessed by following the @entity0 for one year. The iloprost treatment was in general well tolerated and all @entity0 completed the study in accordance with the trial protocol. Primary postoperative wound healing as the responder-criterion was observed in 9 @entity0 (60%) of the iloprost group and in 4 @entity0 (27%) of the control group. @entity0 with iloprost therapy were especially likely to show wound healing if they received the operation approximately in the mid of the treatment phase. The effect of therapy lasted for one year after the end of the treatment in 7 of 9 classified responders of the iloprost group. After one year the responder rate of 47% in the iloprost group was still 20% higher than in the control group. Surgical revisions were necessary in 7 @entity0 (47%) of each group. 2 @entity0 (13%) treated with iloprost and 4 control @entity0 (27%) underwent major amputation. The mortality was 13% = 2 of 15 @entity0 (iloprost) and 7% = 1 of 15 @entity0 (control). Transcutaneous @entity4 -measurements were very reproducible over a long-term period under standardized conditions. A significant effect of iloprost on the tcPO2 was shown. There was a mean increase of 8.1 mmHg +/- 11.2 (mean +/- SD) in the foot of the affected limb after an average 6-week therapy (p < 0.05). At the same time a significant difference in the tcPO2-changes between responders and nonresponders was demonstrated (p < 0.05). @entity0 with primary wound healing had a greater increase in tcPO2 than @entity0 whose wounds did not heal. An increase of at least 10 mmHg (6 @entity0 ) in tcPO2 during the infusion after 3 weeks of therapy predicted primary post-operative wound healing.

title: [Prostacyclin (iloprost) as an adjuvant in local surgical therapy of stage IV XXXX --is quantification of the therapeutic effect possible with tcPO2 measurements?].

answer: @entity3


abstract: @entity1 ( @entity7 ) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). @entity6 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in @entity4 ( @entity4 ) are not clearly known. In the present study, expression of these factors was investigated immunohistochemically in frozen and @entity2 fixed prostate tissues from subjects suffering from @entity4 . Intracytoplasmic localization of @entity7 was observed in the epithelium of nine out of 39 (23.07%) cases. Twenty-six out of 36 (72.22%) frozen @entity4 tissues exhibited moderate to strong staining for immunoreactive @entity3 in the cell membrane. @entity6 oncoprotein was localized in 35 out of 39 cases (89.74%) with the intensity of staining being variable. All nine cases positive for @entity7 were also positive for both @entity3 and @entity6 protein. Staining reaction had no correlation with the serum @entity0 , prostate specific acid phosphatase and @entity5 levels. Immunohistochemical studies indicate the expression of @entity7 , EGF receptor and @entity6 protein in @entity4 tissues. Further study is required to elucidate the precise roles played by these factors in benign growth of prostates.

title: Immunohistochemical localization of @entity1 , @entity3 and XXXX protein in hyperplastic human prostates.

answer: @entity6


abstract: @entity1 ( @entity7 ) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). @entity6 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in @entity4 ( @entity4 ) are not clearly known. In the present study, expression of these factors was investigated immunohistochemically in frozen and @entity2 fixed prostate tissues from subjects suffering from @entity4 . Intracytoplasmic localization of @entity7 was observed in the epithelium of nine out of 39 (23.07%) cases. Twenty-six out of 36 (72.22%) frozen @entity4 tissues exhibited moderate to strong staining for immunoreactive @entity3 in the cell membrane. @entity6 oncoprotein was localized in 35 out of 39 cases (89.74%) with the intensity of staining being variable. All nine cases positive for @entity7 were also positive for both @entity3 and @entity6 protein. Staining reaction had no correlation with the serum @entity0 , prostate specific acid phosphatase and @entity5 levels. Immunohistochemical studies indicate the expression of @entity7 , EGF receptor and @entity6 protein in @entity4 tissues. Further study is required to elucidate the precise roles played by these factors in benign growth of prostates.

title: Immunohistochemical localization of @entity1 , XXXX and @entity6 protein in hyperplastic human prostates.

answer: @entity3


abstract: @entity1 ( @entity7 ) is a potent mitogenic factor which acts by binding to the epidermal growth factor (EGF). @entity6 is a member of the EGF receptor family and is known to be associated with cellular growth and differentiation. The roles played by these factors in @entity4 ( @entity4 ) are not clearly known. In the present study, expression of these factors was investigated immunohistochemically in frozen and @entity2 fixed prostate tissues from subjects suffering from @entity4 . Intracytoplasmic localization of @entity7 was observed in the epithelium of nine out of 39 (23.07%) cases. Twenty-six out of 36 (72.22%) frozen @entity4 tissues exhibited moderate to strong staining for immunoreactive @entity3 in the cell membrane. @entity6 oncoprotein was localized in 35 out of 39 cases (89.74%) with the intensity of staining being variable. All nine cases positive for @entity7 were also positive for both @entity3 and @entity6 protein. Staining reaction had no correlation with the serum @entity0 , prostate specific acid phosphatase and @entity5 levels. Immunohistochemical studies indicate the expression of @entity7 , EGF receptor and @entity6 protein in @entity4 tissues. Further study is required to elucidate the precise roles played by these factors in benign growth of prostates.

title: Immunohistochemical localization of XXXX , @entity3 and @entity6 protein in hyperplastic human prostates.

answer: @entity1


abstract: BACKGROUND: Angiogenesis is a critical event in wound healing, @entity1 growth, and the inflammatory vasculitides. Since @entity0 have a higher incidence of many @entity4 , we examined the effects of female sex @entity6 , particularly @entity3 , on @entity0 umbilical vein endothelial cell (HUVEC) behavior in vitro and on angiogenesis in vivo. METHODS AND RESULTS: HUVECs were grown in @entity5 -free medium before each assay. Exogenous @entity3 (1 to 5 nmol/L) increased cell attachment to laminin, types I and IV collagen, and fibronectin, as well as to tissue culture plastic. After a confluent monolayer of cells was "wounded" by scraping, @entity3 -treated (10(-8) mol/L) cells migrated into the wound three times faster than untreated cells. Cell proliferation on plastic and on laminin increased threefold to fivefold, respectively, in the presence of @entity3 . @entity3 also enhanced the ability of HUVECs to organize into tubular networks when plated on a reconstituted basement membrane, Matrigel. @entity3 effects on both the "wounding" assay and tube formation were blocked by the specific @entity5 receptor antagonist @entity7 . Ovariectomy markedly decreased in vivo vascularization of Matrigel plugs coinjected with basic fibroblast growth factor in @entity2 . With @entity5 replacement, angiogenesis was increased to the levels observed in nonovariectomized @entity2 . CONCLUSIONS: These studies demonstrate that, in vitro and in vivo, @entity3 enhances endothelial cell activities important in neovascularization and suggest a promoting influence of estrogens on angiogenesis.

title: @entity5 promotes angiogenic activity in XXXX umbilical vein endothelial cells in vitro and in a @entity2 model.

answer: @entity0


abstract: BACKGROUND: Angiogenesis is a critical event in wound healing, @entity1 growth, and the inflammatory vasculitides. Since @entity0 have a higher incidence of many @entity4 , we examined the effects of female sex @entity6 , particularly @entity3 , on @entity0 umbilical vein endothelial cell (HUVEC) behavior in vitro and on angiogenesis in vivo. METHODS AND RESULTS: HUVECs were grown in @entity5 -free medium before each assay. Exogenous @entity3 (1 to 5 nmol/L) increased cell attachment to laminin, types I and IV collagen, and fibronectin, as well as to tissue culture plastic. After a confluent monolayer of cells was "wounded" by scraping, @entity3 -treated (10(-8) mol/L) cells migrated into the wound three times faster than untreated cells. Cell proliferation on plastic and on laminin increased threefold to fivefold, respectively, in the presence of @entity3 . @entity3 also enhanced the ability of HUVECs to organize into tubular networks when plated on a reconstituted basement membrane, Matrigel. @entity3 effects on both the "wounding" assay and tube formation were blocked by the specific @entity5 receptor antagonist @entity7 . Ovariectomy markedly decreased in vivo vascularization of Matrigel plugs coinjected with basic fibroblast growth factor in @entity2 . With @entity5 replacement, angiogenesis was increased to the levels observed in nonovariectomized @entity2 . CONCLUSIONS: These studies demonstrate that, in vitro and in vivo, @entity3 enhances endothelial cell activities important in neovascularization and suggest a promoting influence of estrogens on angiogenesis.

title: XXXX promotes angiogenic activity in @entity0 umbilical vein endothelial cells in vitro and in a @entity2 model.

answer: @entity5


abstract: BACKGROUND: Angiogenesis is a critical event in wound healing, @entity1 growth, and the inflammatory vasculitides. Since @entity0 have a higher incidence of many @entity4 , we examined the effects of female sex @entity6 , particularly @entity3 , on @entity0 umbilical vein endothelial cell (HUVEC) behavior in vitro and on angiogenesis in vivo. METHODS AND RESULTS: HUVECs were grown in @entity5 -free medium before each assay. Exogenous @entity3 (1 to 5 nmol/L) increased cell attachment to laminin, types I and IV collagen, and fibronectin, as well as to tissue culture plastic. After a confluent monolayer of cells was "wounded" by scraping, @entity3 -treated (10(-8) mol/L) cells migrated into the wound three times faster than untreated cells. Cell proliferation on plastic and on laminin increased threefold to fivefold, respectively, in the presence of @entity3 . @entity3 also enhanced the ability of HUVECs to organize into tubular networks when plated on a reconstituted basement membrane, Matrigel. @entity3 effects on both the "wounding" assay and tube formation were blocked by the specific @entity5 receptor antagonist @entity7 . Ovariectomy markedly decreased in vivo vascularization of Matrigel plugs coinjected with basic fibroblast growth factor in @entity2 . With @entity5 replacement, angiogenesis was increased to the levels observed in nonovariectomized @entity2 . CONCLUSIONS: These studies demonstrate that, in vitro and in vivo, @entity3 enhances endothelial cell activities important in neovascularization and suggest a promoting influence of estrogens on angiogenesis.

title: @entity5 promotes angiogenic activity in @entity0 umbilical vein endothelial cells in vitro and in a XXXX model.

answer: @entity2


abstract: @entity5 and @entity4 are the two main @entity3 . Both are characterized by inflammation of the tissues surrounding the teeth but while tissue damages observed in @entity5 are mild and reversible, destruction caused by @entity4 is deeper and irreversible. @entity3 and levels of degeneration of tissues surrounding teeth depend on several interacting endogenous and exogenous factors. Polymorphisms of genes encoding molecules that modulate the immune response and tissue homeostasis are the main causes of individual susceptibility to @entity3 . The aim of this study was to investigate @entity1 , @entity2 and @entity8 gene polymorphisms in a large number of subjects affected by either @entity5 or @entity6 . The sample included 750 Italian @entity0 . We found that the @entity7 SNP located in the @entity1 gene promoter was strongly associated with the occurrence of both @entity5 and @entity4 . Indeed, homozygous individuals with variant allele appeared less-susceptible to both @entity5 OR=0.47 (95% C.I. 0.27-0.82) and @entity4 OR=0.36 (95% C.I. 0.21-0.64). No evidence of association between @entity3 and @entity2 or @entity8 polymorphisms was obtained. This data confirmed the role of @entity1 in susceptibility to @entity4 among the Italian population. The evidence that @entity1 polymorphisms are also involved in @entity5 has implications in periodontal disease pathogenesis and reduces the appeal of @entity1 as a @entity4 biomarker.

title: XXXX GENE POLYMORPHISM MODULATES THE RISK OF PERIODONTAL DISEASES.

answer: @entity1


abstract: This study describes local immune responses in @entity5 induced by permanent occlusion of the middle cerebral artery (MCAO) in the @entity0 . The temporal and spatial pattern of leukocyte infiltration was characterized immunocytochemically using monoclonal antibodies against @entity7 , a pan T cell marker, against @entity6 and CD8 for subtyping of T lymphocytes, and ED1, a marker for macrophages. @entity7 + T cells were present in some animals on the pial surface at day 1 and with increasing numbers mainly at the edges of the @entity3 at days 3 and 7. By day 14 their number had significantly decreased. Subtyping of T lymphocytes revealed that @entity6 + helper/inducer T cells were rare, while CD8+ lymphocytes were abundant. Moreover, CD8+ lymphocytes outnumbered @entity7 + T cells indicating the presence of @entity7 -/CD8+ natural killer (NK) cells. ED1+ macrophages primarily infiltrated the core of the @entity3 starting on day 1. Infiltrating leukocytes expressed leukocyte function associated antigen-1 and MHC class I and II antigens. Early after @entity3 , increased expression of the @entity4 was found on vessels and leukocytes. In conclusion, this study shows that lymphocytes enter the nervous system not only in @entity2 , but also in response to primarily 'non-immune' neuronal damage such as @entity1 .

title: Local immune responses in the XXXX cerebral cortex after middle cerebral artery occlusion.

answer: @entity0


abstract: UNASSIGNED: A 68-year-old female @entity0 was admitted in our clinic with severe frontal @entity2 , @entity13 , @entity9 and @entity5 in the context of a previously diagnosed @entity15 . She also had @entity8 , @entity17 , @entity1 . @entity15 was caused by a @entity16 ( @entity16 ) secreting-pituitary macroadenoma, so a transsphenoidal surgery was performed. The postoperative magnetic resonance imaging (MRI) scan revealed a 20  22  25 mm pituitary mass remnant and medical therapy with @entity14 analogues (SSAs) was started. After nine months of treatment with SSAs, she continued having severe @entity2 , the blood pressure was well controlled, but @entity16 secretion was only partially controlled with @entity10 ( @entity10 ) level still above the normal value. The MRI scan showed the same @entity11 remnant with supra- and parasellar right extension and also multiple fronto-temporo-parietal @entity7 that could suggest in the clinical context cerebral @entity6 with @entity12 and @entity3 (CADASIL). According to a pregenetic screening tool, the Pescini Scale, the @entity0 had a 19 points score, which is highly suggestive for CADASIL, an @entity6 due to mutations of the @entity18 gene at the chromosome locus 19p13. In the absence of genetic testing, an alternate way to prove small vessels disease, the skin biopsy, was performed. Electron microscopy showed granular osmiophilic material (GOM) surrounding the vascular smooth muscle cells on that are pathognomonic for the disease. Our report underscores the importance of repeated investigations even in @entity0 with apparently obvious explanations of their condition since they may have @entity4 with the same presenting clinical signs.

title: Cerebral arteriopathy with @entity12 and @entity3 in acromegalic @entity0 with severe XXXX .

answer: @entity2


abstract: UNASSIGNED: A 68-year-old female @entity0 was admitted in our clinic with severe frontal @entity2 , @entity13 , @entity9 and @entity5 in the context of a previously diagnosed @entity15 . She also had @entity8 , @entity17 , @entity1 . @entity15 was caused by a @entity16 ( @entity16 ) secreting-pituitary macroadenoma, so a transsphenoidal surgery was performed. The postoperative magnetic resonance imaging (MRI) scan revealed a 20  22  25 mm pituitary mass remnant and medical therapy with @entity14 analogues (SSAs) was started. After nine months of treatment with SSAs, she continued having severe @entity2 , the blood pressure was well controlled, but @entity16 secretion was only partially controlled with @entity10 ( @entity10 ) level still above the normal value. The MRI scan showed the same @entity11 remnant with supra- and parasellar right extension and also multiple fronto-temporo-parietal @entity7 that could suggest in the clinical context cerebral @entity6 with @entity12 and @entity3 (CADASIL). According to a pregenetic screening tool, the Pescini Scale, the @entity0 had a 19 points score, which is highly suggestive for CADASIL, an @entity6 due to mutations of the @entity18 gene at the chromosome locus 19p13. In the absence of genetic testing, an alternate way to prove small vessels disease, the skin biopsy, was performed. Electron microscopy showed granular osmiophilic material (GOM) surrounding the vascular smooth muscle cells on that are pathognomonic for the disease. Our report underscores the importance of repeated investigations even in @entity0 with apparently obvious explanations of their condition since they may have @entity4 with the same presenting clinical signs.

title: Cerebral arteriopathy with XXXX and @entity3 in acromegalic @entity0 with severe @entity2 .

answer: @entity12


abstract: UNASSIGNED: A 68-year-old female @entity0 was admitted in our clinic with severe frontal @entity2 , @entity13 , @entity9 and @entity5 in the context of a previously diagnosed @entity15 . She also had @entity8 , @entity17 , @entity1 . @entity15 was caused by a @entity16 ( @entity16 ) secreting-pituitary macroadenoma, so a transsphenoidal surgery was performed. The postoperative magnetic resonance imaging (MRI) scan revealed a 20  22  25 mm pituitary mass remnant and medical therapy with @entity14 analogues (SSAs) was started. After nine months of treatment with SSAs, she continued having severe @entity2 , the blood pressure was well controlled, but @entity16 secretion was only partially controlled with @entity10 ( @entity10 ) level still above the normal value. The MRI scan showed the same @entity11 remnant with supra- and parasellar right extension and also multiple fronto-temporo-parietal @entity7 that could suggest in the clinical context cerebral @entity6 with @entity12 and @entity3 (CADASIL). According to a pregenetic screening tool, the Pescini Scale, the @entity0 had a 19 points score, which is highly suggestive for CADASIL, an @entity6 due to mutations of the @entity18 gene at the chromosome locus 19p13. In the absence of genetic testing, an alternate way to prove small vessels disease, the skin biopsy, was performed. Electron microscopy showed granular osmiophilic material (GOM) surrounding the vascular smooth muscle cells on that are pathognomonic for the disease. Our report underscores the importance of repeated investigations even in @entity0 with apparently obvious explanations of their condition since they may have @entity4 with the same presenting clinical signs.

title: Cerebral arteriopathy with @entity12 and XXXX in acromegalic @entity0 with severe @entity2 .

answer: @entity3


abstract: UNASSIGNED: A 68-year-old female @entity0 was admitted in our clinic with severe frontal @entity2 , @entity13 , @entity9 and @entity5 in the context of a previously diagnosed @entity15 . She also had @entity8 , @entity17 , @entity1 . @entity15 was caused by a @entity16 ( @entity16 ) secreting-pituitary macroadenoma, so a transsphenoidal surgery was performed. The postoperative magnetic resonance imaging (MRI) scan revealed a 20  22  25 mm pituitary mass remnant and medical therapy with @entity14 analogues (SSAs) was started. After nine months of treatment with SSAs, she continued having severe @entity2 , the blood pressure was well controlled, but @entity16 secretion was only partially controlled with @entity10 ( @entity10 ) level still above the normal value. The MRI scan showed the same @entity11 remnant with supra- and parasellar right extension and also multiple fronto-temporo-parietal @entity7 that could suggest in the clinical context cerebral @entity6 with @entity12 and @entity3 (CADASIL). According to a pregenetic screening tool, the Pescini Scale, the @entity0 had a 19 points score, which is highly suggestive for CADASIL, an @entity6 due to mutations of the @entity18 gene at the chromosome locus 19p13. In the absence of genetic testing, an alternate way to prove small vessels disease, the skin biopsy, was performed. Electron microscopy showed granular osmiophilic material (GOM) surrounding the vascular smooth muscle cells on that are pathognomonic for the disease. Our report underscores the importance of repeated investigations even in @entity0 with apparently obvious explanations of their condition since they may have @entity4 with the same presenting clinical signs.

title: Cerebral arteriopathy with @entity12 and @entity3 in acromegalic XXXX with severe @entity2 .

answer: @entity0


abstract: The @entity0 B centromere has been used as a model for centromere epigenetics and as the basis for building artificial chromosomes. However, there are no sequence resources for this important centromere. Here we used transposon display for the centromere-specific retroelement CRM2 to identify a collection of 40 sequence tags that flank CRM2 insertion points on the B chromosome. These were confirmed to lie within the centromere by assaying deletion breakpoints from centromere misdivision derivatives (intracentromere breakages caused by centromere fission). Markers were grouped together on the basis of their association with other markers in the misdivision series and assembled into a pseudocontig containing 10.1 kb of sequence. To identify sequences that interact directly with centromere proteins, we carried out chromatin immunoprecipitation using antibodies to @entity1 ( @entity1 ), a defining feature of functional centromeric sequences. The @entity1 chromatin immunoprecipitation map was interpreted relative to the known transmission rates of centromere misdivision derivatives to identify a centromere core domain spanning 33 markers. A subset of seven markers was mapped in additional B centromere misdivision derivatives with the use of unique primer pairs. A derivative previously shown to have no canonical centromere sequences (Telo3-3) lacks these core markers. Our results provide a molecular map of the B chromosome centromere and identify key sequences within the map that interact directly with @entity1 .

title: Generation of a XXXX B Centromere Minimal Map Containing the Central Core Domain.

answer: @entity0


abstract: Importance: Several epidemiological studies show an alarming global increase in incidence of @entity2 and @entity3 . Objectives: To examine the cost-effectiveness of 2 population-based @entity3 screening methods and to assess their budget effect and the influence on @entity3 epidemiological findings. Design, Setting, and @entity0 : A Markov model with a latent period of 20 years and a time horizon of 50 years was used to analyze the cost-effectiveness (societal perspective) and budget effect (public health care payer perspective) of 2 population-based @entity3 screening programs in Belgium compared with the absence of a screening program. A health economic analysis was based on a clinical trial performed in 2014 in Belgium. In the economic model, the total Belgian population 18 years or older was assumed to have been invited for the screening program. Main Outcomes and Measures: The influence of the screening program on @entity3 epidemiological findings and the cost per quality-adjusted life-year (QALY) gained, as well as the budget effect, expressed as the net costs for the health care payer over 50 years. Results: All @entity0 (1668 @entity1 [ @entity1 ] and 248 lesion-directed screening [LDS]) were screened by a team of 6 dermatologists from March 14 to 18, 2014, for TSBE and April 22 and 25 to 27, 2014, for LDS. Both screening strategies produced a gain in QALYs, resulting in incremental cost-effectiveness ratios of    33   072 (US  35   475) per QALY in @entity0 and    18   687 (US  20   044) per QALY in @entity0 for @entity1 and    34   836 (US  37   365) per QALY in @entity0 and    19   470 (US  20   884) per QALY in @entity0 for LDS. With a 1-time screening, a 4.0% decrease in the incidence rates of stage III and IV @entity2 was predicted at the population level relative to the comparator. The budget effect analysis demonstrated that during 20 years, a 1-time screening would incur a net cost for the health care payer of almost    36 million (US  38.6 million) for @entity1 or just over    6 million (US  6.4 million) for LDS (   4.1 [US  4.40] or    0.7 [US  0.80], respectively, per adult). Conclusions and Relevance: These results can be interpreted as cost-effective at a willingness-to-pay threshold in Belgium of    35   000 (US  37   541) per QALY gained. Based on these findings, a 1-time @entity1 in the general adult population 18 years or older is the most cost-effective strategy and is predicted to result in a reduction of @entity3 mortality over 20 years and 50 years. The cost-effectiveness for @entity3 screening is higher in @entity0 than in @entity0 .

title: Cost-effectiveness and Budget Effect Analysis of a Population-Based XXXX Screening.

answer: @entity3


abstract: BACKGROUND: Macular Integrity Assessment microperimetry assesses macular sensitivity to projected point light sources and maps eye movements to assess fixation stability. Although microperimetry is gaining prominence as an assessment tool in clinical and research settings, there is no consensus on whether it should be performed before or after @entity3 . No studies to date have examined the effect of @entity3 on results. The aim of this project was to elucidate the effect of @entity3 on microperimetry outcomes. DESIGN: Prospective audit. @entity0 : Twenty healthy @entity0 from postoperative @entity2 clinic and 10 @entity0 with @entity6 to simulate a disease with @entity1 . METHODS: Subjects underwent 10-2 68-point field testing using the Macular Integrity Assessment microperimeter on each eye. Subjects then underwent randomized dilation of one eye, and the test was repeated in both eyes. MAIN OUTCOME MEASURES: We compared changes in threshold sensitivity and fixation stability pre-pupil and post- @entity3 . The undilated eye was analysed for any learning or @entity4 effect caused by test repetition. RESULTS: Dilation produced no significant effect on threshold sensitivity (dilation effect: -0.29 decibels, P  =  0.23) or fixation stability in healthy controls or in @entity6 @entity0 (dilation effect: +0.08log bivariate contour @entity5 area, P  =  0.14). There was also no significant learning effect seen in the undilated eye, with no improvement in threshold sensitivity (order of eye testing: +0.03log bivariate contour @entity5 area, P  =  0.71). CONCLUSIONS: In the clinical setting, @entity0 may be tested for 10 degree microperimetry with or without @entity3 , as both scenarios yield consistent and interchangeable results.

title: Effects of XXXX on MAIA microperimetry.

answer: @entity3


abstract: The purpose of this study was to evaluate adjuvant drug therapies combined with standard laser excision in the treatment of recurrent @entity5 . Previous studies have presented conflicting data on the efficacy of various treatments, including interferon and @entity6 . A retrospective study of 34 @entity0 with moderate to severe @entity3 who underwent both laser surgery and adjuvant therapy was therefore performed. All @entity0 were treated with interferon. Five interferon failures received @entity6 , and three with recalcitrant disease received @entity4 . @entity7 produced a complete response in 16 @entity0 and partial response in 12 @entity0 . @entity1 had a slightly higher response to interferon than adult-onset disease. @entity6 produced no response in all five @entity0 . @entity4 demonstrated a marked improvement in both severity of disease and treatment interval in all three @entity0 . Serious side effects were limited to one interferon @entity0 with @entity2 , which resolved with discontinuation of therapy. We conclude that adjuvant therapy including interferon and @entity4 is clearly of benefit in the treatment of @entity0 with @entity5 . A detailed approach to surgery combined with an interferon dosing regimen is presented. Further study of @entity4 appears warranted.

title: Adjuvant drug strategies in the treatment of recurrent XXXX .

answer: @entity5


abstract: UNASSIGNED: King scallop contamination (Pecten maximus) by @entity2 , a @entity1 produced by some species of the diatom Pseudo-nitzschia, is highly problematic because of its lengthy retention in the bivalve tissue, leading to prolonged fishery closures. Data collected within the French Phytoplankton and Phycotoxin monitoring network (REPHY) over the 1995-2012 period were used to characterize the seasonal dynamics and the interannual variability of P.-nitzschia spp. blooms as well as the contamination of king scallop fishing grounds, in six contrasted bays distributed along the French Atlantic coast and English Channel. Monitoring revealed that these toxic events have become more frequent since the year 2000, but with varying magnitudes, frequencies and timing depending on the bay. Two bays, located in southern Brittany, exhibited both recurrent contaminations and high P.-nitzschia abundances. The Brest bay and the Seine bay were intermittently affected. The Pertuis Breton exhibited only one major toxic event related to an exceptionally intense bloom of P.-nitzschia in 2010, and the Saint Brieuc bay neither showed significant contamination nor high P.-nitzschia abundance. While high P.-nitzschia abundance appeared to be correlated to scallop @entity0 , this study highlights the difficulty in linking P.-nitzschia spp. blooms to king scallop contamination through monitoring. Indeed, P.-nitzschia was determined at the genus level and data regarding species abundances and their @entity0 levels are an absolute prerequisite to further assess the environmental control of ASP events. As results describe distinct P.-nitzschia bloom dynamics along the French coast, this may suggest distinct controlling factors. They also revealed that major climatic events, such as the winter storm Xynthia in 2010, can trigger @entity0 in P.-nitzschia over a large spatial scale and impact king scallop fisheries all along the coast.

title: Two decades of Pseudo-nitzschia spp. blooms and king scallop (Pecten maximus) contamination by XXXX along the French Atlantic and English Channel coasts: Seasonal dynamics, spatial heterogeneity and interannual variability.

answer: @entity2


abstract: OBJECTIVES: Since recent years, it is known that immunocompromised @entity0 can suffer of prolonged norovirus symptoms and @entity2 up to multiple years. Little is known about the prevalence of chronic norovirus infection among solid organ transplant (SOT) recipients. In this study 2182 SOT recipients were retrospectively tested for chronic norovirus infection. METHODS: The first and last norovirus positive faecal sample of SOT recipients was sequenced to distinguish between persisting and re-infection. @entity0 charts were reviewed to obtain data on health statues and treatments. RESULTS: One hundred one of 2182 (4.6%) recipients were norovirus infected and 23 (22.8%) of these developed chronic norovirus infection. @entity1 was found among allogeneic heart-, kidney-, and lung transplant recipients. The median shedding period at the end of the study period was 218 days (range 32-1164). CONCLUSIONS: This study shows that chronic norovirus infection is not a rare phenomenon among SOT recipients in a tertiary care hospital exposed to norovirus. Further research is needed to study the risk of norovirus transmission to other immunocompromised @entity0 in the hospital and to the general population.

title: XXXX among solid organ recipients in a tertiary care hospital, the Netherlands, 2006 - 2014.

answer: @entity1


abstract: BACKGROUND: Postprandial dysmetabolism-an exaggerated spike in @entity7 , @entity6 , and insulin-increases @entity3 risk by inducing oxidative stress, @entity2 , and @entity4 . @entity8 -rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of @entity9 , but there is little research on their postprandial effects. OBJECTIVE: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (   1 lb. or 0.45 kg fresh strawberries) to a high-fat (50 g total fat) meal on postprandial vascular function, as well as @entity5 , @entity6 , and insulin responses. DESIGN: Healthy, overweight or @entity1 [mean    SEM body mass index (in kg/m(2)): 31    0.5] adults (mean    SEM age: 28    2 y; 17 @entity0 and 13 @entity0 ) consumed a control meal and a strawberry meal in a randomized crossover design. Testing sessions were separated by >= 1 wk for @entity0 and    1 mo for @entity0 to control for hormonal variations. Blood samples were obtained before the meal and 0.5, 1, 2, and 4 h after the meal. Central blood pressure and arterial stiffness indexes were measured at baseline and 2 and 4 h postmeal with the use of pulse waveform analysis. RESULTS: There were no significant differences between the strawberry and control meals for any outcomes. Consumption of either meal significantly decreased the augmentation index at 2 and 4 h (P < 0.002) and significantly increased @entity7 , insulin, and @entity6 at all time points (P < 0.001) relative to baseline. CONCLUSIONS: The strawberry intervention did not alter vascular function or attenuate postprandial metabolic derangements in @entity7 , @entity6 , or insulin relative to the control meal. Additional research is needed to clarify whether strawberries or other @entity8 -rich interventions improve postprandial responses, and future studies should take into account the acute meal-induced improvements in measures of vascular function. This trial was registered at clinicaltrials.gov as NCT01989637.

title: Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of XXXX risk: a randomized controlled trial.

answer: @entity3


abstract: BACKGROUND: Pulsed-wave Doppler determination of the pulmonary artery acceleration time (PAAT) as a surrogate for pulmonary artery pressure was found to be of clinical value for assessment of @entity1 ( @entity1 ) with studies to date exclusively performed in adults. This study aims to provide representative, normal reference values for PAAT in @entity0 of all ages. Moreover, we validated abnormal PAAT values in 54 @entity0 with @entity1 . METHODS AND RESULTS: We conducted a prospective echocardiographic study in 756 healthy @entity0 (aged 1 day to 18 years) and in 54 @entity0 with @entity1 . Possible associations of age, body length, body weight, body surface area, and heart rate on PAAT were investigated. The PAAT correlated positively with age (r=0.848), body length (r=0.871), body surface area (r=0.856), and body weight (r=0.825) and negatively with heart rate (r=-0.906). PAAT increased with age (neonates: median: 81 ms, range: 53-104; 18th year of life: median: 151 ms, range: 107-187). Receiver operating characteristic analysis for detecting @entity1 @entity0 using age-specific z scores showed an excellent performance of PAAT (P<0.001; area under the curve, 0.98; 95% confidence interval, 0.97-0.99) with a best cutoff score according to Youden index of -1.565 (sensitivity: 92%, specificity: 96%). PAAT values of @entity1 @entity0 negatively correlated (  =-0.497) with pulmonary vascular resistance. CONCLUSIONS: The PAAT normal reference values and z scores we provide here will be useful to identify @entity0 with a shortened PAAT. Abnormal PAAT values with scores <-2 were predictive of @entity1 .

title: Normal Reference Values and z Scores of the Pulmonary Artery Acceleration Time in XXXX and Its Importance for the Assessment of Pulmonary Hypertension.

answer: @entity0


abstract: UNASSIGNED: Dendritic cells are professional APCs that play a central role in the initiation of immune responses. The limited ex vivo availability of dendritic cells inspires the widespread use of bone marrow-derived dendritic cells as an alternative in research. However, the functional characteristics of bone marrow-derived dendritic cells are incompletely understood. Therefore, we compared functional and phenotypic characteristics of @entity0 bone marrow-derived dendritic cells generated with @entity3 / @entity5 or @entity11 ligand bone marrow-derived dendritic cells. A comparison of surface markers revealed that @entity11 ligand-bone marrow-derived dendritic cells expressed signal regulatory protein a, CD103, and @entity4 and baseline levels of MHC class II, @entity9 , and @entity10 , which were highly up-regulated upon stimulation. Conversely, @entity3 / @entity5 -bone marrow-derived dendritic cells constitutively expressed signal regulatory protein a, CD11c, and @entity7 but only mildly up-regulated MHC class II, @entity9 , or @entity10 following stimulation. Expression of dendritic cell-associated core transcripts was restricted to @entity11 ligand-bone marrow-derived dendritic cells . @entity3 / @entity5 -bone marrow-derived dendritic cells were superior at phagocytosis but were outperformed by @entity11 ligand-bone marrow-derived dendritic cells at antigen presentation and T cell stimulation in vitro. Stimulated @entity3 / @entity5 -bone marrow-derived dendritic cells secreted more TNF, @entity6 , @entity8 , and NO, whereas @entity11 ligand-bone marrow-derived dendritic cells secreted more @entity2 and @entity1 . Finally, whereas @entity3 / @entity5 -bone marrow-derived dendritic cell culture supernatants added to resting T cell cultures promoted forkhead box p3(+) regulatory T cell populations, @entity11 ligand-bone marrow-derived dendritic cell culture supernatants drove Th17 differentiation. We conclude that @entity0 @entity3 / @entity5 -bone marrow-derived dendritic cells and @entity11 ligand-bone marrow-derived dendritic cells are functionally distinct. Our data support the current rationale that @entity11 ligand-bone marrow-derived dendritic cells mostly resemble classic dendritic cells but comprise additional minor subpopulations, whereas @entity3 / @entity5 -bone marrow-derived dendritic cells resemble monocyte-derived inflammatory dendritic cells (iNOS-positive monocyte-derived cells).

title: @entity0 bone marrow-derived dendritic cells generated with @entity3 / XXXX or FLT3L exhibit distinct phenotypical and functional characteristics.

answer: @entity5


abstract: UNASSIGNED: Dendritic cells are professional APCs that play a central role in the initiation of immune responses. The limited ex vivo availability of dendritic cells inspires the widespread use of bone marrow-derived dendritic cells as an alternative in research. However, the functional characteristics of bone marrow-derived dendritic cells are incompletely understood. Therefore, we compared functional and phenotypic characteristics of @entity0 bone marrow-derived dendritic cells generated with @entity3 / @entity5 or @entity11 ligand bone marrow-derived dendritic cells. A comparison of surface markers revealed that @entity11 ligand-bone marrow-derived dendritic cells expressed signal regulatory protein a, CD103, and @entity4 and baseline levels of MHC class II, @entity9 , and @entity10 , which were highly up-regulated upon stimulation. Conversely, @entity3 / @entity5 -bone marrow-derived dendritic cells constitutively expressed signal regulatory protein a, CD11c, and @entity7 but only mildly up-regulated MHC class II, @entity9 , or @entity10 following stimulation. Expression of dendritic cell-associated core transcripts was restricted to @entity11 ligand-bone marrow-derived dendritic cells . @entity3 / @entity5 -bone marrow-derived dendritic cells were superior at phagocytosis but were outperformed by @entity11 ligand-bone marrow-derived dendritic cells at antigen presentation and T cell stimulation in vitro. Stimulated @entity3 / @entity5 -bone marrow-derived dendritic cells secreted more TNF, @entity6 , @entity8 , and NO, whereas @entity11 ligand-bone marrow-derived dendritic cells secreted more @entity2 and @entity1 . Finally, whereas @entity3 / @entity5 -bone marrow-derived dendritic cell culture supernatants added to resting T cell cultures promoted forkhead box p3(+) regulatory T cell populations, @entity11 ligand-bone marrow-derived dendritic cell culture supernatants drove Th17 differentiation. We conclude that @entity0 @entity3 / @entity5 -bone marrow-derived dendritic cells and @entity11 ligand-bone marrow-derived dendritic cells are functionally distinct. Our data support the current rationale that @entity11 ligand-bone marrow-derived dendritic cells mostly resemble classic dendritic cells but comprise additional minor subpopulations, whereas @entity3 / @entity5 -bone marrow-derived dendritic cells resemble monocyte-derived inflammatory dendritic cells (iNOS-positive monocyte-derived cells).

title: @entity0 bone marrow-derived dendritic cells generated with XXXX / @entity5 or FLT3L exhibit distinct phenotypical and functional characteristics.

answer: @entity3


abstract: UNASSIGNED: Dendritic cells are professional APCs that play a central role in the initiation of immune responses. The limited ex vivo availability of dendritic cells inspires the widespread use of bone marrow-derived dendritic cells as an alternative in research. However, the functional characteristics of bone marrow-derived dendritic cells are incompletely understood. Therefore, we compared functional and phenotypic characteristics of @entity0 bone marrow-derived dendritic cells generated with @entity3 / @entity5 or @entity11 ligand bone marrow-derived dendritic cells. A comparison of surface markers revealed that @entity11 ligand-bone marrow-derived dendritic cells expressed signal regulatory protein a, CD103, and @entity4 and baseline levels of MHC class II, @entity9 , and @entity10 , which were highly up-regulated upon stimulation. Conversely, @entity3 / @entity5 -bone marrow-derived dendritic cells constitutively expressed signal regulatory protein a, CD11c, and @entity7 but only mildly up-regulated MHC class II, @entity9 , or @entity10 following stimulation. Expression of dendritic cell-associated core transcripts was restricted to @entity11 ligand-bone marrow-derived dendritic cells . @entity3 / @entity5 -bone marrow-derived dendritic cells were superior at phagocytosis but were outperformed by @entity11 ligand-bone marrow-derived dendritic cells at antigen presentation and T cell stimulation in vitro. Stimulated @entity3 / @entity5 -bone marrow-derived dendritic cells secreted more TNF, @entity6 , @entity8 , and NO, whereas @entity11 ligand-bone marrow-derived dendritic cells secreted more @entity2 and @entity1 . Finally, whereas @entity3 / @entity5 -bone marrow-derived dendritic cell culture supernatants added to resting T cell cultures promoted forkhead box p3(+) regulatory T cell populations, @entity11 ligand-bone marrow-derived dendritic cell culture supernatants drove Th17 differentiation. We conclude that @entity0 @entity3 / @entity5 -bone marrow-derived dendritic cells and @entity11 ligand-bone marrow-derived dendritic cells are functionally distinct. Our data support the current rationale that @entity11 ligand-bone marrow-derived dendritic cells mostly resemble classic dendritic cells but comprise additional minor subpopulations, whereas @entity3 / @entity5 -bone marrow-derived dendritic cells resemble monocyte-derived inflammatory dendritic cells (iNOS-positive monocyte-derived cells).

title: XXXX bone marrow-derived dendritic cells generated with @entity3 / @entity5 or FLT3L exhibit distinct phenotypical and functional characteristics.

answer: @entity0


abstract: A nude @entity2 model for @entity0 @entity4 has been developed to examine possible relationships between amplification/over-expression of the @entity6 oncogene and altered regulation of expression of specific integrin subunits during @entity1 progression. Subcutaneous (ectopic) or intra-adrenal (orthotopic) injection of the @entity4 cell lines SK-N-SH or IMR-32 has generated a number of derivative @entity1 cell lines. Tumor cell lines derived from SK-N-SH cells (which do not express @entity6 ) or IMR-32 cells (which over-express @entity6 ) produce @entity1 at higher rates when re-injected into the subcutaneous space of @entity2 . Moreover, cell lines derived from @entity1 initiated by IMR-32 cells exhibit shorter latent periods than do IMR-32 cells direct from tissue culture. With regard to integrin subunit expression, SK-N-SH and related cell lines express high levels of @entity5 , which is associated with the alpha 2 and alpha 3 integrin subunits (predominantly alpha 3). IMR-32 cells display reduced beta 1 expression, and that which is produced is not associated with common alpha subunits. @entity0 cells, which express @entity6 at even higher levels than do IMR-32 cells, express even less beta 1. Interestingly, the @entity1 -derived cell lines (especially those from @entity1 initiated in adrenal glands) also exhibit reduced integrin expression compared with the parental cell lines; this reduction is associated with the enhanced @entity1 take rate observed when the cells are re-injected into @entity2 . Our results raise the possibility of a relationship between over-expression of @entity6 and down-regulation of @entity5 expression (possibly some alpha subunits also). In addition, the data suggest that @entity0 @entity4 -derived cell lines which exhibit reduced integrin expression display more @entity3 growth in @entity2 .

title: Inverse expressions of the XXXX oncogene and @entity5 in @entity0 @entity4 : relationships to disease progression in a nude @entity2 model system.

answer: @entity6


abstract: A nude @entity2 model for @entity0 @entity4 has been developed to examine possible relationships between amplification/over-expression of the @entity6 oncogene and altered regulation of expression of specific integrin subunits during @entity1 progression. Subcutaneous (ectopic) or intra-adrenal (orthotopic) injection of the @entity4 cell lines SK-N-SH or IMR-32 has generated a number of derivative @entity1 cell lines. Tumor cell lines derived from SK-N-SH cells (which do not express @entity6 ) or IMR-32 cells (which over-express @entity6 ) produce @entity1 at higher rates when re-injected into the subcutaneous space of @entity2 . Moreover, cell lines derived from @entity1 initiated by IMR-32 cells exhibit shorter latent periods than do IMR-32 cells direct from tissue culture. With regard to integrin subunit expression, SK-N-SH and related cell lines express high levels of @entity5 , which is associated with the alpha 2 and alpha 3 integrin subunits (predominantly alpha 3). IMR-32 cells display reduced beta 1 expression, and that which is produced is not associated with common alpha subunits. @entity0 cells, which express @entity6 at even higher levels than do IMR-32 cells, express even less beta 1. Interestingly, the @entity1 -derived cell lines (especially those from @entity1 initiated in adrenal glands) also exhibit reduced integrin expression compared with the parental cell lines; this reduction is associated with the enhanced @entity1 take rate observed when the cells are re-injected into @entity2 . Our results raise the possibility of a relationship between over-expression of @entity6 and down-regulation of @entity5 expression (possibly some alpha subunits also). In addition, the data suggest that @entity0 @entity4 -derived cell lines which exhibit reduced integrin expression display more @entity3 growth in @entity2 .

title: Inverse expressions of the @entity6 oncogene and @entity5 in @entity0 @entity4 : relationships to disease progression in a nude XXXX model system.

answer: @entity2


abstract: A nude @entity2 model for @entity0 @entity4 has been developed to examine possible relationships between amplification/over-expression of the @entity6 oncogene and altered regulation of expression of specific integrin subunits during @entity1 progression. Subcutaneous (ectopic) or intra-adrenal (orthotopic) injection of the @entity4 cell lines SK-N-SH or IMR-32 has generated a number of derivative @entity1 cell lines. Tumor cell lines derived from SK-N-SH cells (which do not express @entity6 ) or IMR-32 cells (which over-express @entity6 ) produce @entity1 at higher rates when re-injected into the subcutaneous space of @entity2 . Moreover, cell lines derived from @entity1 initiated by IMR-32 cells exhibit shorter latent periods than do IMR-32 cells direct from tissue culture. With regard to integrin subunit expression, SK-N-SH and related cell lines express high levels of @entity5 , which is associated with the alpha 2 and alpha 3 integrin subunits (predominantly alpha 3). IMR-32 cells display reduced beta 1 expression, and that which is produced is not associated with common alpha subunits. @entity0 cells, which express @entity6 at even higher levels than do IMR-32 cells, express even less beta 1. Interestingly, the @entity1 -derived cell lines (especially those from @entity1 initiated in adrenal glands) also exhibit reduced integrin expression compared with the parental cell lines; this reduction is associated with the enhanced @entity1 take rate observed when the cells are re-injected into @entity2 . Our results raise the possibility of a relationship between over-expression of @entity6 and down-regulation of @entity5 expression (possibly some alpha subunits also). In addition, the data suggest that @entity0 @entity4 -derived cell lines which exhibit reduced integrin expression display more @entity3 growth in @entity2 .

title: Inverse expressions of the @entity6 oncogene and XXXX in @entity0 @entity4 : relationships to disease progression in a nude @entity2 model system.

answer: @entity5


abstract: A nude @entity2 model for @entity0 @entity4 has been developed to examine possible relationships between amplification/over-expression of the @entity6 oncogene and altered regulation of expression of specific integrin subunits during @entity1 progression. Subcutaneous (ectopic) or intra-adrenal (orthotopic) injection of the @entity4 cell lines SK-N-SH or IMR-32 has generated a number of derivative @entity1 cell lines. Tumor cell lines derived from SK-N-SH cells (which do not express @entity6 ) or IMR-32 cells (which over-express @entity6 ) produce @entity1 at higher rates when re-injected into the subcutaneous space of @entity2 . Moreover, cell lines derived from @entity1 initiated by IMR-32 cells exhibit shorter latent periods than do IMR-32 cells direct from tissue culture. With regard to integrin subunit expression, SK-N-SH and related cell lines express high levels of @entity5 , which is associated with the alpha 2 and alpha 3 integrin subunits (predominantly alpha 3). IMR-32 cells display reduced beta 1 expression, and that which is produced is not associated with common alpha subunits. @entity0 cells, which express @entity6 at even higher levels than do IMR-32 cells, express even less beta 1. Interestingly, the @entity1 -derived cell lines (especially those from @entity1 initiated in adrenal glands) also exhibit reduced integrin expression compared with the parental cell lines; this reduction is associated with the enhanced @entity1 take rate observed when the cells are re-injected into @entity2 . Our results raise the possibility of a relationship between over-expression of @entity6 and down-regulation of @entity5 expression (possibly some alpha subunits also). In addition, the data suggest that @entity0 @entity4 -derived cell lines which exhibit reduced integrin expression display more @entity3 growth in @entity2 .

title: Inverse expressions of the @entity6 oncogene and @entity5 in @entity0 XXXX : relationships to disease progression in a nude @entity2 model system.

answer: @entity4


abstract: A nude @entity2 model for @entity0 @entity4 has been developed to examine possible relationships between amplification/over-expression of the @entity6 oncogene and altered regulation of expression of specific integrin subunits during @entity1 progression. Subcutaneous (ectopic) or intra-adrenal (orthotopic) injection of the @entity4 cell lines SK-N-SH or IMR-32 has generated a number of derivative @entity1 cell lines. Tumor cell lines derived from SK-N-SH cells (which do not express @entity6 ) or IMR-32 cells (which over-express @entity6 ) produce @entity1 at higher rates when re-injected into the subcutaneous space of @entity2 . Moreover, cell lines derived from @entity1 initiated by IMR-32 cells exhibit shorter latent periods than do IMR-32 cells direct from tissue culture. With regard to integrin subunit expression, SK-N-SH and related cell lines express high levels of @entity5 , which is associated with the alpha 2 and alpha 3 integrin subunits (predominantly alpha 3). IMR-32 cells display reduced beta 1 expression, and that which is produced is not associated with common alpha subunits. @entity0 cells, which express @entity6 at even higher levels than do IMR-32 cells, express even less beta 1. Interestingly, the @entity1 -derived cell lines (especially those from @entity1 initiated in adrenal glands) also exhibit reduced integrin expression compared with the parental cell lines; this reduction is associated with the enhanced @entity1 take rate observed when the cells are re-injected into @entity2 . Our results raise the possibility of a relationship between over-expression of @entity6 and down-regulation of @entity5 expression (possibly some alpha subunits also). In addition, the data suggest that @entity0 @entity4 -derived cell lines which exhibit reduced integrin expression display more @entity3 growth in @entity2 .

title: Inverse expressions of the @entity6 oncogene and @entity5 in XXXX @entity4 : relationships to disease progression in a nude @entity2 model system.

answer: @entity0


abstract: The aims of this study were to investigate the role of cytokines ( @entity0 necrosis factor alpha ( @entity3 ), @entity4 ( @entity4 ) and @entity6 ( @entity6 ) in augmenting graft-versus- @entity7 (GVL). We have investigated the effector cells involved in GVL, by studying the role of these cells in purging of the cell line K562 in short-term bone marrow cultures. The effect of the addition in vitro of @entity9 was also studied. Monitoring of purging was achieved by @entity2 assays, DNA analysis and the use of the polymerase chain reaction for the detection of bcr/abl transcripts in the Philadelphia positive (Ph+) K562 cell line. Supernatants from @entity6 -treated and non-treated bone marrow were tested for cytokine production ( @entity3 and @entity4 ). The results have shown that the main cytotoxic effector cells in the bone marrow generated by @entity6 have the @entity8 + @entity5 + phenotype. Overnight incubation of bone marrow was sufficient to generate cytotoxic cells as measured by @entity10 (Cr51) release assays. Measurable levels of @entity3 but not @entity4 were also detected in supernatants. Addition of @entity3 and @entity4 to the @entity6 in the bone marrow cultures augmented the @entity2 but tended to inhibit progenitor cell growth as measured by granulocyte-macrophage colony-forming unit (GM-CFU) and erythroid blast-forming unit (BFU-e) assays. An estimate of the purging of the marrow could also be achieved by DNA analysis of K562 DNA in bone marrow. The bcr/abl transcript could still be detected by PCR analysis in marrow containing 1% K562 and treated with @entity6 for 24 h, but by 6 days of incubation the bcr/abl transcript was weak or undectable. The results suggest that although reduction in the proportion of @entity7 in contaminated marrow can be detected after incubation with @entity6 for 24 h, complete elimination of minimal @entity1 requires longer incubation times.

title: Cytokine treatment of human bone marrow activates anti- XXXX effector cells: monitoring of purging by polymerase chain reaction and DNA analysis.

answer: @entity7


abstract: BACKGROUND: Accurate diagnosis of @entity2 usually relies on fluoroscopic guided procedures. As fluoroscopy is not routinely available in many respiratory units, an approach not using fluoroscopy but with a high diagnostic yield is highly desirable. METHODS: Immediate cytological examination of multiple @entity3 using Riu's stain, a modified Wright's stain, was performed in 38 @entity0 with @entity2 not visible at bronchoscopy. The results were compared with the final diagnoses determined by histological examination or subsequent Papanicolaou staining of cytological specimens and clinical course. RESULTS: Of the 38 @entity0 29 were subsequently confirmed to have a @entity1 . Our method provided a diagnosis of @entity1 in 86% of these lesions. The accuracy (91%) and sensitivity (88%) were higher for lesions > 3 cm in diameter than for those of diameter < or = 3 cm (87% and 83%). There were no false positive results. The 29 lesions correctly diagnosed as malignant by Riu's stain required significantly fewer @entity3 (mean (SD) 3 (2)) than the nine benign lesions (5 (4)). CONCLUSIONS: This technique provides a high diagnostic yield, avoids the need for fluoroscopy, and is probably safer than percutaneous biopsy.

title: Multiple XXXX with immediate Riu's stain via flexible fibreoptic bronchoscopy without fluoroscopic guidance in the diagnosis of @entity1 .

answer: @entity3


abstract: BACKGROUND: Accurate diagnosis of @entity2 usually relies on fluoroscopic guided procedures. As fluoroscopy is not routinely available in many respiratory units, an approach not using fluoroscopy but with a high diagnostic yield is highly desirable. METHODS: Immediate cytological examination of multiple @entity3 using Riu's stain, a modified Wright's stain, was performed in 38 @entity0 with @entity2 not visible at bronchoscopy. The results were compared with the final diagnoses determined by histological examination or subsequent Papanicolaou staining of cytological specimens and clinical course. RESULTS: Of the 38 @entity0 29 were subsequently confirmed to have a @entity1 . Our method provided a diagnosis of @entity1 in 86% of these lesions. The accuracy (91%) and sensitivity (88%) were higher for lesions > 3 cm in diameter than for those of diameter < or = 3 cm (87% and 83%). There were no false positive results. The 29 lesions correctly diagnosed as malignant by Riu's stain required significantly fewer @entity3 (mean (SD) 3 (2)) than the nine benign lesions (5 (4)). CONCLUSIONS: This technique provides a high diagnostic yield, avoids the need for fluoroscopy, and is probably safer than percutaneous biopsy.

title: Multiple @entity3 with immediate Riu's stain via flexible fibreoptic bronchoscopy without fluoroscopic guidance in the diagnosis of XXXX .

answer: @entity1


abstract: Over the past few years, substantial clinical data have been presented showing that incretin-based therapies are effective @entity1 -lowering agents. Specifically, @entity4 agonists demonstrate an efficacy comparable to insulin treatment with minimal @entity3 and have favorable effects on body weight. Thus, many of the unmet clinical needs noted from prior therapies are addressed by these agents. However, even after many years of use, many continue to raise concerns about the long-term safety of these agents and, in particular, the concern with @entity2 . This clearly remains a complicated topic. Thus, in this issue of @entity0 Care, we continue to update our readers on this very important issue by presenting two studies evaluating incretin-based medications and risk of @entity2 . Both have undergone significant revisions based on peer review that provided significant clarification of the data. We applaud both author groups for being extremely responsive in providing the additional data and revisions requested by the editorial team. As such, because of the critical peer review, we feel both articles achieve the high level we require for @entity0 Care and are pleased to now present them to our readers. In keeping with our aim to comprehensively evaluate this topic, we asked for additional commentaries to be prepared. In the narrative outlined below, Prof. Edwin A.M. Gale provides a commentary on the report that focuses on clinical trials of liraglutide in the treatment of @entity0 . In the narrative that follows Prof. Gale's contribution, Dr. Laurent Azoulay provides a commentary about the remaining uncertainty in this area and also discusses the results from a nationwide population-based case-control study. From the journal's perspective, both of the articles on @entity2 and incretin-based therapies reported in this issue have been well vetted, and we feel both of the commentaries are insightful.

title: Smoke or fire? Acute XXXX and the liraglutide trials.

answer: @entity2


abstract: BACKGROUND: The aim of this study was to evaluate the effectiveness and safety of @entity6 for preventing @entity5 ( @entity5 ) after lumbar spine surgery. METHODS: In this randomized, controlled study, 665 @entity0 who underwent lumbar surgery were randomly assigned to receive either @entity6 or @entity7 . @entity6 and @entity7 were used for preventing @entity1 . The occurrence of postoperative efficacy endpoint events ( @entity1 ) and safety endpoint events ( @entity3 ) was compared for each group. RESULTS: Efficacy endpoint results: in the @entity6 group, there were 6 thrombotic events (1.7 %), 2 cases with severe @entity5 (0.6 %), and 3 cases with symptomatic @entity5 (0.9 %). In the @entity7 group, there were 10 thrombotic events (3.1 %), 4 cases with severe @entity5 (1.2 %), and 6 cases with symptomatic @entity5 (1.9 %). Safety endpoint results: in the @entity6 group, there were 21 cases with @entity3 events (6.2 %), 2 cases with severe @entity3 (0.6 %), and 19 cases with non-severe @entity3 (5.6 %). In the @entity7 group, there were 21 @entity3 events (6.2 %), 1 case with severe @entity3 (0.3 %), and 16 cases with non-severe @entity3 (4.9 %). The incidences of @entity4 , including severe and symptomatic @entity5 , were not significantly different between the two groups (P > 0.05). Bleeding event rates, including severe and non-severe @entity3 , were also not significantly different. CONCLUSIONS: @entity6 proved to be equally effective as @entity7 for anticoagulation therapy, with both drugs exhibiting a similar prevention effect against postoperative @entity5 after lumbar spine surgery, without increasing the risk of @entity2 .

title: Comparison of XXXX and @entity7 for preventing @entity5 after lumbar spine surgery.

answer: @entity6


abstract: BACKGROUND: The aim of this study was to evaluate the effectiveness and safety of @entity6 for preventing @entity5 ( @entity5 ) after lumbar spine surgery. METHODS: In this randomized, controlled study, 665 @entity0 who underwent lumbar surgery were randomly assigned to receive either @entity6 or @entity7 . @entity6 and @entity7 were used for preventing @entity1 . The occurrence of postoperative efficacy endpoint events ( @entity1 ) and safety endpoint events ( @entity3 ) was compared for each group. RESULTS: Efficacy endpoint results: in the @entity6 group, there were 6 thrombotic events (1.7 %), 2 cases with severe @entity5 (0.6 %), and 3 cases with symptomatic @entity5 (0.9 %). In the @entity7 group, there were 10 thrombotic events (3.1 %), 4 cases with severe @entity5 (1.2 %), and 6 cases with symptomatic @entity5 (1.9 %). Safety endpoint results: in the @entity6 group, there were 21 cases with @entity3 events (6.2 %), 2 cases with severe @entity3 (0.6 %), and 19 cases with non-severe @entity3 (5.6 %). In the @entity7 group, there were 21 @entity3 events (6.2 %), 1 case with severe @entity3 (0.3 %), and 16 cases with non-severe @entity3 (4.9 %). The incidences of @entity4 , including severe and symptomatic @entity5 , were not significantly different between the two groups (P > 0.05). Bleeding event rates, including severe and non-severe @entity3 , were also not significantly different. CONCLUSIONS: @entity6 proved to be equally effective as @entity7 for anticoagulation therapy, with both drugs exhibiting a similar prevention effect against postoperative @entity5 after lumbar spine surgery, without increasing the risk of @entity2 .

title: Comparison of @entity6 and @entity7 for preventing XXXX after lumbar spine surgery.

answer: @entity5


abstract: BACKGROUND: The aim of this study was to evaluate the effectiveness and safety of @entity6 for preventing @entity5 ( @entity5 ) after lumbar spine surgery. METHODS: In this randomized, controlled study, 665 @entity0 who underwent lumbar surgery were randomly assigned to receive either @entity6 or @entity7 . @entity6 and @entity7 were used for preventing @entity1 . The occurrence of postoperative efficacy endpoint events ( @entity1 ) and safety endpoint events ( @entity3 ) was compared for each group. RESULTS: Efficacy endpoint results: in the @entity6 group, there were 6 thrombotic events (1.7 %), 2 cases with severe @entity5 (0.6 %), and 3 cases with symptomatic @entity5 (0.9 %). In the @entity7 group, there were 10 thrombotic events (3.1 %), 4 cases with severe @entity5 (1.2 %), and 6 cases with symptomatic @entity5 (1.9 %). Safety endpoint results: in the @entity6 group, there were 21 cases with @entity3 events (6.2 %), 2 cases with severe @entity3 (0.6 %), and 19 cases with non-severe @entity3 (5.6 %). In the @entity7 group, there were 21 @entity3 events (6.2 %), 1 case with severe @entity3 (0.3 %), and 16 cases with non-severe @entity3 (4.9 %). The incidences of @entity4 , including severe and symptomatic @entity5 , were not significantly different between the two groups (P > 0.05). Bleeding event rates, including severe and non-severe @entity3 , were also not significantly different. CONCLUSIONS: @entity6 proved to be equally effective as @entity7 for anticoagulation therapy, with both drugs exhibiting a similar prevention effect against postoperative @entity5 after lumbar spine surgery, without increasing the risk of @entity2 .

title: Comparison of @entity6 and XXXX for preventing @entity5 after lumbar spine surgery.

answer: @entity7


abstract: BACKGROUND: We evaluated the management, outcome and @entity3 risk in a cohort of @entity1 @entity0 with mild symptoms treated with intravenous @entity4 (tPA) within the first 4.5 h. METHODS: We analysed data from a prospective @entity1 thrombolysis registry. A total of 1,043 @entity0 received tPA between 2010 and 2014 in the 5 @entity1 units of the RESUVAL @entity1 network (Rh  ne Valley, France). Among them, 170 @entity0 had a National Institute of Health @entity1 Scale (NIHSS) score  <=4 (minor group: MG) before tPA and 873 @entity0 had a NIHSS score >4. RESULTS: A high rate (77%) of excellent outcome (3-month-modified Rankin Scale score  <=1) was observed in the MG. No symptomatic @entity5 occurred and the rate of any @entity3 @entity6 was 5%. Fifty-four percent of the MG @entity0 had visible @entity2 before tPA. @entity0 of the MG were less likely to be transported by Emergency Medical Services and to be directly admitted to the @entity1 unit or to imaging. Median delays from onset to admission, from admission to imaging and from onset to tPA were longer in the MG. CONCLUSION: Our data provided evidence of safety and suggested potential benefit of thrombolysis in @entity0 with NIHSS score  <=4. A majority of these @entity0 exhibited @entity2 before thrombolysis. Most often, @entity0 with mild @entity1 are not given priority in terms of the mode of transport, direct admission to @entity1 unit and rapid imaging, resulting in an increased delay from onset to thrombolysis. Health system improvements are needed to provide all suspected @entity1 victims equal access to imaging and treatment on an emergency basis.

title: Thrombolysis for Acute XXXX : Outcome and Barriers to Management. Results from the RESUVAL @entity1 Network.

answer: @entity1


abstract: BACKGROUND: We evaluated the management, outcome and @entity3 risk in a cohort of @entity1 @entity0 with mild symptoms treated with intravenous @entity4 (tPA) within the first 4.5 h. METHODS: We analysed data from a prospective @entity1 thrombolysis registry. A total of 1,043 @entity0 received tPA between 2010 and 2014 in the 5 @entity1 units of the RESUVAL @entity1 network (Rh  ne Valley, France). Among them, 170 @entity0 had a National Institute of Health @entity1 Scale (NIHSS) score  <=4 (minor group: MG) before tPA and 873 @entity0 had a NIHSS score >4. RESULTS: A high rate (77%) of excellent outcome (3-month-modified Rankin Scale score  <=1) was observed in the MG. No symptomatic @entity5 occurred and the rate of any @entity3 @entity6 was 5%. Fifty-four percent of the MG @entity0 had visible @entity2 before tPA. @entity0 of the MG were less likely to be transported by Emergency Medical Services and to be directly admitted to the @entity1 unit or to imaging. Median delays from onset to admission, from admission to imaging and from onset to tPA were longer in the MG. CONCLUSION: Our data provided evidence of safety and suggested potential benefit of thrombolysis in @entity0 with NIHSS score  <=4. A majority of these @entity0 exhibited @entity2 before thrombolysis. Most often, @entity0 with mild @entity1 are not given priority in terms of the mode of transport, direct admission to @entity1 unit and rapid imaging, resulting in an increased delay from onset to thrombolysis. Health system improvements are needed to provide all suspected @entity1 victims equal access to imaging and treatment on an emergency basis.

title: Thrombolysis for Acute @entity1 : Outcome and Barriers to Management. Results from the RESUVAL XXXX Network.

answer: @entity1


abstract: UNASSIGNED: The @entity2 ) triple gene block 1 (TGB1) protein is required for virus cell-to-cell movement. However, little information is available about how these activities are regulated by post-translational modifications. In this study, we showed that the @entity2 Xinjiang strain TGB1 (XJTGB1) is phosphorylated in vivo and in vitro by protein kinase CK2 from @entity1 and Nicotiana benthamiana. Liquid chromatography tandem mass spectrometry analysis and in vitro phosphorylation assays demonstrated that Thr-401 is the major phosphorylation site of the XJTGB1 protein, and suggested that a Thr-395 kinase docking site supports Thr-401 phosphorylation. Substitution of @entity3 ( @entity4 ) only moderately impaired virus cell-to-cell movement and @entity0 . In contrast, the @entity5 ( @entity6 ) virus mutant was unable to systemically infect N. benthamiana but had only minor effects in monocot hosts. Substitution of @entity7 interfered with monocot and dicot cell-to-cell movement and the plants failed to develop @entity0 . However, virus derivatives with single @entity8 developed nearly normal @entity0 in the monocot hosts but were unable to infect N. benthamiana systemically, and none of the double mutants was able to infect dicot and monocot hosts. The mutant XJTGB1 @entity4 / @entity6 weakened in vitro interactions between XJTGB1 and XJTGB3 proteins but had little effect on XJTGB1 RNA-binding ability. Taken together, our results support a critical role of CK2 phosphorylation in the movement of @entity2 in monocots and dicots, and provide new insights into the roles of phosphorylation in TGB protein functions.

title: Phosphorylation of TGB1 by protein kinase CK2 promotes XXXX movement in monocots and dicots.

answer: @entity2


abstract: BACKGROUND/AIMS: Urocortin 1, a corticotropin-releasing factor related peptide, @entity1 under stressful conditions. We investigated the effect of urocortin 1 on @entity1 using an experimental model with isolated @entity0 colon in which the blood flow and intestinal nerves were preserved. Furthermore, we assessed whether this effect was mediated by adrenergic or cholinergic nerves. METHODS: Colonic motility was measured in the proximal and distal parts of resected @entity0 colon. The colon resected from the peritoneum was stabilized, and then urocortin 1 (13.8, 138, 277, and 1,388 pM) was administered via a blood vessel. Motility index was measured in the last 5 min of the 15 min administration of urocortin 1 and expressed as percentage change from baseline. Subsequently, the change in motility was measured by perfusing urocortin 1 in colons pretreated with @entity6 , @entity3 , @entity5 , @entity4 , or @entity2 . RESULTS: At concentrations of 13.8, 138, 277, and 1,388 pM, urocortin 1 increased the motility of proximal colon (20.4    7.2%,48.4    20.9%, 67.0    25.8%, and 64.2    20.9%, respectively) and the motility of distal colon (3.3    3.3%, 7.8    7.8%, 71.1    28.6%,and 87.4    32.5%, respectively). The motility induced by urocortin 1 was significantly decreased by @entity4 to 2.4    2.4% in proximal colon and 3.4    3.4% in distal colon (p <   0.05). However, @entity2 , @entity3 , @entity6 , and @entity5 did not inhibit motility. CONCLUSIONS: Urocortin 1 increased @entity1 and it is considered that this effect was directly mediated by local muscarinic cholinergic receptors.

title: The effect of urocortin 1 on motility in isolated, vascularly perfused XXXX colon.

answer: @entity0


abstract: BACKGROUND: Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to @entity4 ( @entity4 ) and @entity6 , conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community-based cohorts are lacking. METHODS AND RESULTS: We examined plasma N-terminal pro B-type natriuretic peptide (NTproBNP) levels according to race in 9137 @entity5 Risk in Communities (ARIC) Study @entity0 (22% African American) without prevalent @entity3 at visit 4 (1996-1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P<0.0001). In multivariable models, adjusted log NTproBNP levels were 40% lower (95% confidence interval [CI], -43, -36) in African Americans, compared to Caucasians, which was consistent across subgroups of age, gender, @entity4 , @entity1 , insulin resistance, and @entity2 . African-American race was also significantly associated with having nondetectable NTproBNP (adjusted OR, 5.74; 95% CI, 4.22, 7.80). In multivariable analyses in African Americans, a 10% increase in genetic European ancestry was associated with a 7% (95% CI, 1, 13) increase in adjusted log NTproBNP. CONCLUSIONS: African Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for @entity4 and its sequalae in this population.

title: Racial Differences in Circulating Natriuretic Peptide Levels: The XXXX Risk in Communities Study.

answer: @entity5


abstract: OBJECTIVES: Data on the seroprevalence of @entity3 ) in China are limited. The objective of this study was to characterise the serological profiles of @entity4 in a rural Chinese population and help establish effective vaccine policy. METHODS: Serum antibodies against the major capsid protein L1 of 10 HPV types (HPV-3, 6, 11, 16, 18, 45, 52, 57, 58 and 75) were evaluated with Luminex-based multiplex serology in a population-based study of 5548 adults (including 1587 couples) aged 25-65   years enrolled from rural Anyang, China, in 2007-2009. RESULTS: The seroprevalence for any HPV type and any of the types HPV-6/11/16/18 was 64.8% and 34.4%, respectively. 30.3% of adults were seropositive for any mucosal high-risk (HR) HPV, and HPV-58 (10.6%), @entity5 (9.7%) and HPV-18 (9.3%) were the three most common types. 24.8% of seropositive individuals were @entity1 . Seroprevalence for most HPV types was similar among @entity0 and @entity0 . While mucosal low-risk HPV seropositivity was found to significantly decrease with age, the prevalence of antibodies to mucosal HR antigens showed a general trend of increase with age. The lifetime number of sex partners was independently associated with @entity1 . Positive correlation of spousal seropositivity was observed for mucosal HPV but not for cutaneous HPV. CONCLUSIONS: @entity4 was common in both @entity0 and @entity0 in rural China. HPV seroprevalence differed significantly with age, @entity2 status. These findings will be useful for evaluating and establishing HPV vaccination programmes.

title: Seroprevalence of 10 XXXX types in the general rural population of Anyang, China: a cross-sectional study.

answer: @entity3


abstract: BACKGROUND: In normal subjects treadmill exercise usually produces the greatest maximal @entity1 consumption (VO2max). This may not be true for @entity0 with severe @entity3 ( @entity3 ) in whom bicycle exercise, which offers support for the shoulder girdle, may produce a higher @entity1 consumption than treadmill exercise. The aim of this study was to determine which mode of exercise produced the greatest @entity1 consumption in @entity0 with severe @entity3 . METHODS: Eight @entity0 with severe @entity3 (forced expiratory volume in one second (FEV1) more than three standardised residuals below predicted) exercised to a symptom limited maximum on a bicycle and on a treadmill on separate days. The workload on the bicycle wa increased by 10 watts each minute, and the treadmill gradient was increased by 2.5% alternate minutes whilst the speed remained constant. Measurements of @entity1 consumption (VO2), ventilation (VE), heart rate, and @entity1 saturation were made, and capillary blood gases were measured before and immediately after exercise. @entity2 concentration was measured before and four minutes after exercise. RESULTS: There were no differences at peak exercise between the two forms of exercise for VO2 (median 11.7 and 12.2 ml/min/kg for bicycle and treadmill, respectively), for VE (median 26.6 and 25.0 l/min, respectively), and for heart rate (median 119 and 115 beats/min, respectively). The median @entity2 levels after bicycle exercise were higher than those after the treadmill (2.42 v 0.94 mmol/l). CONCLUSIONS: Although only a small number of @entity0 was studied and individual variability was large, there was no clear difference between the two forms of exercise. Regular bicycle exercise was unfamiliar to this group of @entity0 and generated the greatest @entity2 response. The results do not support the hypothesis that bicycle exercise will produce a better performance in @entity0 with severe @entity3 , but the two modes of exercise cannot be used interchangeably.

title: Comparison of peak XXXX consumption during cycle and treadmill exercise in severe @entity3 .

answer: @entity1


abstract: BACKGROUND: In normal subjects treadmill exercise usually produces the greatest maximal @entity1 consumption (VO2max). This may not be true for @entity0 with severe @entity3 ( @entity3 ) in whom bicycle exercise, which offers support for the shoulder girdle, may produce a higher @entity1 consumption than treadmill exercise. The aim of this study was to determine which mode of exercise produced the greatest @entity1 consumption in @entity0 with severe @entity3 . METHODS: Eight @entity0 with severe @entity3 (forced expiratory volume in one second (FEV1) more than three standardised residuals below predicted) exercised to a symptom limited maximum on a bicycle and on a treadmill on separate days. The workload on the bicycle wa increased by 10 watts each minute, and the treadmill gradient was increased by 2.5% alternate minutes whilst the speed remained constant. Measurements of @entity1 consumption (VO2), ventilation (VE), heart rate, and @entity1 saturation were made, and capillary blood gases were measured before and immediately after exercise. @entity2 concentration was measured before and four minutes after exercise. RESULTS: There were no differences at peak exercise between the two forms of exercise for VO2 (median 11.7 and 12.2 ml/min/kg for bicycle and treadmill, respectively), for VE (median 26.6 and 25.0 l/min, respectively), and for heart rate (median 119 and 115 beats/min, respectively). The median @entity2 levels after bicycle exercise were higher than those after the treadmill (2.42 v 0.94 mmol/l). CONCLUSIONS: Although only a small number of @entity0 was studied and individual variability was large, there was no clear difference between the two forms of exercise. Regular bicycle exercise was unfamiliar to this group of @entity0 and generated the greatest @entity2 response. The results do not support the hypothesis that bicycle exercise will produce a better performance in @entity0 with severe @entity3 , but the two modes of exercise cannot be used interchangeably.

title: Comparison of peak @entity1 consumption during cycle and treadmill exercise in severe XXXX .

answer: @entity3


abstract: The majority of @entity4 (80-90%) are caused by major blunt @entity5 . Penetrating injuries account for the rest. @entity4 is seen most often in @entity0 with @entity2 . More seldom, the @entity3 can be caused by energetic blunt @entity5 . The @entity3 can either be intraperitoneal or extraperitoneal. The symptoms are macroscopic haematuria, @entity1 and, in some @entity0 , an inability to avoid. Retrograde cystography is the diagnostic procedure of choice. An intravenous infusion pyelogram does not provide adequate examination of the bladder. The @entity3 is treated by operative closure and drainage by catheter. @entity3 may be treated with only catheter drainage and close clinical evaluation. We describe two @entity0 with intraperitoneal @entity4 after low energetic @entity5 .

title: [ XXXX . Diagnosis, etiology and treatment].

answer: @entity4


abstract: It has been shown that, although iodinated swimming-pool waters are usually free from coliform bacteria and enterococci, the total counts frequently become relatively high. @entity2 and Alcaligenes faecalis have been shown to account for most of these high counts. It was of interest, therefore, to compare the microbial flora of four alternately chlorinated and iodinated swimming pools. By means of the membrane filter method and suitable selective media, examinations were made for total viable counts, coliform bacteria, enterococci, staphylococci, @entity3 , and @entity0 . Colonies also were picked from membrane filters incubated on standard plate count agar and identified. The results showed that, although viable counts were significantly higher during the iodinated periods, the specific types of bacteria determined were either fewer than or the same as in chlorinated periods. During chlorination, the predominant microbial flora consisted of staphylococci and members of the genus Bacillus. During iodination, however, the @entity2 -A. faecalis group accounted for 92 to 99% of the microbial flora. The accumulation of high numbers of these bacteria was shown to be due to their @entity1 resistance and their ability to grow rapidly in pool water in the absence of free @entity1 .

title: Factors influencing the occurrence of high numbers of XXXX -resistant bacteria in iodinated swimming pools.

answer: @entity1


abstract: From February, 1975 through October, 1990, 26 @entity0 underwent surgical treatment for @entity4 at Tokai University Hospital. The overall operative mortality rate was 11.5% (3/26). The three @entity0 who died were suffering from aortic @entity2 ( @entity2 ) in the active stage. Among 16 @entity0 in the active stage, the mortality rate was 18.7% (3/16) Among 10 @entity0 with @entity2 ( @entity2 ) in the healed stage, all survived. Among the total of 21 @entity0 with @entity2 , the mortality rate was zero and among those with @entity2 , the rate was 60% (3/5). Various species of streptococci were the most common organisms encountered, followed by Staphylococcus epidermides. The two @entity2 @entity0 with S. epidermides died. Nine of the 11 @entity2 cases in the active stage were of the localized type. Only one case of the localized type of @entity2 suffered from an infected mitral bioprosthetic valve. The 6 extensive-type cases had @entity5 (2NVE, 4PVE). Three @entity0 with the extensive type of @entity2 died. We conclude that @entity0 with @entity4 who develop progressive @entity3 , recurrent embolization, or progressive @entity1 despite antimicrobial treatments, should undergo prompt valve replacement within 7 days after institution of therapy.

title: Surgical treatment of XXXX .

answer: @entity4


abstract: BACKGROUND AND PURPOSE: The accuracy of routine ultrasonography in detecting severe @entity2 was evaluated in comparison with cerebral angiography. The precision of ultrasonographic criteria in predicting the risk of @entity1 was also assessed. METHODS: A total of 1011 symptomatic carotid bifurcations were studied in @entity0 from the North American Symptomatic Carotid Endarterectomy Trial (NASCET). Given that all @entity0 were considered for entry into the trial, the chance of a verification bias affecting the analyses was minimized. The ultrasonographic data consisted of peak systolic velocities and frequency changes from both the internal and common carotid arteries. Angiographic @entity3 was calculated as in NASCET. Receiver operating characteristic (ROC) curves were constructed from the ultrasonographic data for the detection of 70% or greater @entity3 on the basis of an angiographic assessment. Kaplan-Meier @entity1 -free survival curves were used to predict the risk of @entity1 . RESULTS: The areas under the ROC curves ranged from 0.74 to 0.75 (95% confidence interval [CI], 0.69 to 0.79). The sensitivities and specificities ranged from 0.65 to 0.71. The risk of @entity1 at 18 months declined sharply as the degree of angiographically defined @entity3 declined from 99% to 70%. No pattern of decline was apparent on the basis of the ultrasonographic data. CONCLUSIONS: The results indicate that the accuracy of ultrasonography is moderate when flow parameters are used to assess the degree of @entity3 . Ultrasonography should be used as a screening tool to exclude @entity0 with no @entity4 from further testing. Conventional angiography remains an essential investigation before assigning the risk of @entity1 and deciding appropriate treatment for extracranial @entity4 .

title: Accuracy and prognostic consequences of ultrasonography in identifying severe XXXX . North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: @entity5 is a risk factor for clinical @entity2 and for subclinical @entity1 and @entity3 . These subclinical lesions are linked to small-vessel pathology. @entity4 ( @entity4 ) are another biomarker of @entity7 but have not yet been studied in @entity5 . METHODS: Identification of @entity4 in 63 migraineurs (25 with aura/35 without aura/3 unknown aura status) and 359 controls (aged, 73-85 years) from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) magnetic resonance imaging study. We assessed the modifying role of @entity5 in the co-occurrence of @entity4 , @entity3 , and white matter hyperintensity-load. RESULTS: Infratentorial microbleeds were more prevalent in @entity6 @entity0 than controls (14% versus 4%). Prevalence of other @entity4 , @entity3 , and @entity1 did not differ between groups. Migraineurs with @entity4 had more often @entity3 than controls with @entity4 (65% versus 43%). In comparison with controls with @entity3 , migraineurs with @entity3 had more commonly @entity4 (55% versus 30%). CONCLUSIONS: @entity5 , notably without aura, is associated with infratentorial @entity4 at older age. @entity4 and @entity3 co-occur more often in @entity5 than in controls. This supports the hypothesis of small-vessel involvement in @entity5 pathophysiology.

title: Infratentorial Microbleeds: Another Sign of Microangiopathy in XXXX .

answer: @entity5


abstract: BACKGROUND AND PURPOSE: Dual-energy CT features the opportunity to differentiate among up to 3 different materials because the absorption of x-rays depends on the applied tube voltage and the atomic number of the material. For example, it is possible to distinguish between blood-brain barrier disruption and an @entity3 following treatment for a @entity1 . The aim of this study was to evaluate whether dual-energy CT is capable of distinguishing intra-arterial contrast agent from residually clotted vessels immediately after @entity1 therapy. MATERIALS AND METHODS: Sixteen @entity0 (9 @entity0 , 7 @entity0 ; mean age, 63.6    13.09 years) were examined. Measurements were made on the postinterventional dual-energy CT virtual noncontrast, iodine map, and "weighted" brain window (weighted dual-energy) series. Postinterventional conventional angiography was used as the criterion standard method. RESULTS: A residual clot was found in 10 @entity0 . On the virtual noncontrast series, the Hounsfield attenuation of the clotted arteries was higher than that in the corresponding perfused contralateral arteries (53.72    9.42 HU versus 41.64    7.87 HU; P < .05). The latter had higher absorption values on the weighted dual-energy series than on the virtual noncontrast series (49.37    7.44 HU versus 41.64    7.87 HU; P < .05). The sensitivity for the detection of a residual clot was 90%; the specificity was 83.3%, and the accuracy was 87.5%. Interrater agreement was good (k = 0.733). CONCLUSIONS: Dual-energy CT may be valuable in the detection of clot persistence or early re- @entity2 without the necessity of additional contrast administration. However, its relevance for the prediction of outcomes remains to be determined in further studies.

title: Residual Thromboembolic Material in Cerebral Arteries after XXXX Therapy Can Be Identified by Dual-Energy CT.

answer: @entity1