abstract: UNASSIGNED: The aim of the study is to evaluate gender-related socio-demographic and clinical differences in a large sample of inpatients with @entity1 spectrum disorder. A sample of 353 acute @entity0 , consecutively hospitalized between January 2007 and December 2008 in the Psychiatric Emergency Service of the San Giovanni Battista Hospital, was recruited. Psychiatric assessment included the Clinical Global Impression Scale-Severity (CGI-S), the Brief Psychiatric Rating Scale (BPRS) and the Global Assessment of Functioning (GAF). Differences between the groups were tested using chi-square test and ANOVA. Data were analyzed using a three-way MANOVA with the six BPRS scales with repeated measures for admission/discharge and BPRS total score baseline and independent groups for @entity0 and @entity0 . A two-way ANOVA for repeated measures was performed for CGI-S and GAF. @entity0 were younger, more likely to be never married, more often substance abusers. Male @entity0 showed both lower @entity2 and anergia symptom scores and higher activation symptom scores than female @entity0 . Brief hospitalization was shown to be highly effective in both groups. Females showed a significantly better improvement in anergia and activation than males. The present evidence suggests that management of acute @entity3 should target specific gender differences which should influence therapeutic approach in all its modalities.

title: Gender differences in 353 inpatients with acute XXXX : The experience of one Psychiatric Emergency Service of Turin.

answer: @entity3


abstract: @entity1 following @entity2 ( @entity2 ) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after @entity2 ( @entity2 ). @entity0 bone marrow-derived mesenchymal stem cells (MSCs), genetically engineered to overexpress @entity5 , receptor of @entity4 ( @entity4 ), were pre-differentiated into cells carrying neuronal features via co-culture with @entity4 overproducing Schwann cells in 3-dimensional @entity6 ( @entity6 ) scaffold for 14 days in  vitro. Intra- @entity6 formation of MSC assemblies emulating neural network (MSC- @entity6 ) were verified morphologically via electron microscopy (EM) and functionally by whole-cell patch clamp recording of spontaneous post-synaptic currents. The differentiated MSCs still partially maintained prototypic property with the expression of some mesodermal cytokines. MSC- @entity6 or @entity6 was then grafted acutely into a 2  mm-wide transection gap in the T9-T10 spinal cord segments of adult @entity0 . Eight weeks later, hindlimb function of the MSC- @entity6 -treated @entity2 @entity0 was significantly improved relative to controls receiving the @entity6 or lesion only as indicated by BBB score. The MSC- @entity6 transplantation also significantly recovered cortical motor evoked potential (CMEP). Histologically, MSC-derived neuron-like cells maintained their synapse-like structures in  vivo; they additionally formed similar connections with host neurites (i.e., mostly serotonergic fibers plus a few corticospinal axons; validated by double-labeled immuno-EM). Moreover, motor cortex electrical stimulation triggered @entity3 expression in the grafted and lumbar spinal cord cells of the treated @entity0 only. Our data suggest that MSC-derived neuron-like cells resulting from @entity4 - @entity5 -induced differentiation can partially integrate into transected spinal cord and this strategy should be further investigated for reconstructing disrupted neural circuits.

title: Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after @entity0 XXXX .

answer: @entity2


abstract: @entity1 following @entity2 ( @entity2 ) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after @entity2 ( @entity2 ). @entity0 bone marrow-derived mesenchymal stem cells (MSCs), genetically engineered to overexpress @entity5 , receptor of @entity4 ( @entity4 ), were pre-differentiated into cells carrying neuronal features via co-culture with @entity4 overproducing Schwann cells in 3-dimensional @entity6 ( @entity6 ) scaffold for 14 days in  vitro. Intra- @entity6 formation of MSC assemblies emulating neural network (MSC- @entity6 ) were verified morphologically via electron microscopy (EM) and functionally by whole-cell patch clamp recording of spontaneous post-synaptic currents. The differentiated MSCs still partially maintained prototypic property with the expression of some mesodermal cytokines. MSC- @entity6 or @entity6 was then grafted acutely into a 2  mm-wide transection gap in the T9-T10 spinal cord segments of adult @entity0 . Eight weeks later, hindlimb function of the MSC- @entity6 -treated @entity2 @entity0 was significantly improved relative to controls receiving the @entity6 or lesion only as indicated by BBB score. The MSC- @entity6 transplantation also significantly recovered cortical motor evoked potential (CMEP). Histologically, MSC-derived neuron-like cells maintained their synapse-like structures in  vivo; they additionally formed similar connections with host neurites (i.e., mostly serotonergic fibers plus a few corticospinal axons; validated by double-labeled immuno-EM). Moreover, motor cortex electrical stimulation triggered @entity3 expression in the grafted and lumbar spinal cord cells of the treated @entity0 only. Our data suggest that MSC-derived neuron-like cells resulting from @entity4 - @entity5 -induced differentiation can partially integrate into transected spinal cord and this strategy should be further investigated for reconstructing disrupted neural circuits.

title: Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after XXXX @entity2 .

answer: @entity0


abstract: UNASSIGNED: We evaluate the clinical effects and radiological findings of the Wallis interspinous device (Zimmer, Warsaw, IN, USA) for the treatment of @entity1 after a minimum 5year follow-up period. A total of 26 adult @entity0 underwent a primary discectomy followed by fixation of the segment with the Wallis interspinous device between December 2007 and August 2008. Twelve @entity0 and 14 @entity0 with an age range of 43 to 56years (average: 47.6) were included. The visual analogue scale (VAS) for @entity4 , @entity2 Index (ODI), foraminal height (FH), anterior disc height (aDH) and posterior disc height (pDH), range of motion (ROM) and Pfirrmann grades were obtained and compared before and after surgery. The VAS and ODI significantly decreased postoperatively (p<0.05). The postoperative FH and pDH values increased significantly compared with the preoperative levels (p<0.01) and the increase in the FH and pDH values remained statistically significant during the follow-up period. There were no statistically significant changes in the aDH values before and after surgery (p>0.05). Also, there were no statistically significant changes in the ROM and Pfirrmann grade at the instrumented level and at the cephalad-adjacent segment (p>0.05). In our study, no @entity0 underwent further surgery because of a re-prolapse or progression of index level degeneration or @entity3 . The Wallis interspinous device was a useful alternative for treating @entity1 and it offered a significant minimum 5year symptom control.

title: Minimum 5year follow-up of XXXX treated with discectomy and the Wallis interspinous device.

answer: @entity1


abstract: BACKGROUND: We hypothesized @entity3 ( @entity3 ) demonstrate higher rates of @entity0 and higher dominance ranks than control (CTR) offspring with normal weight at term; if @entity0 is advantageous during resource scarcity, developmental programming may lead to an association between @entity0 and @entity3 . METHODS: We studied 22 group-housed @entity4 (ages 3-5  years). CTR (male n  =  8, female n  =  5) mothers ate ad  libitum. @entity3 (male n  =  4, female n  =  5) mothers were fed 70% feed eaten by CTR mothers during pregnancy and lactation. RESULTS: @entity3 showed higher rates of @entity0 (P  <  0.02). Dominance ranks and physical @entity0 rates did not differ between groups. CONCLUSIONS: High rates of @entity2 might reflect developmental programming of behavioral phenotypes enhancing @entity1 . Friendly displays may reflect reconciliation. Potential mechanisms include neurodevelopment and learning. Exploration of @entity3 as a risk factor for behavioral patterns is important for developing diagnostic and therapeutic strategies.

title: Increased @entity0 and affiliative display behavior in intrauterine growth restricted XXXX .

answer: @entity4


abstract: BACKGROUND: We hypothesized @entity3 ( @entity3 ) demonstrate higher rates of @entity0 and higher dominance ranks than control (CTR) offspring with normal weight at term; if @entity0 is advantageous during resource scarcity, developmental programming may lead to an association between @entity0 and @entity3 . METHODS: We studied 22 group-housed @entity4 (ages 3-5  years). CTR (male n  =  8, female n  =  5) mothers ate ad  libitum. @entity3 (male n  =  4, female n  =  5) mothers were fed 70% feed eaten by CTR mothers during pregnancy and lactation. RESULTS: @entity3 showed higher rates of @entity0 (P  <  0.02). Dominance ranks and physical @entity0 rates did not differ between groups. CONCLUSIONS: High rates of @entity2 might reflect developmental programming of behavioral phenotypes enhancing @entity1 . Friendly displays may reflect reconciliation. Potential mechanisms include neurodevelopment and learning. Exploration of @entity3 as a risk factor for behavioral patterns is important for developing diagnostic and therapeutic strategies.

title: Increased XXXX and affiliative display behavior in intrauterine growth restricted @entity4 .

answer: @entity0


abstract: UNASSIGNED: The nonphysiological mechanical shear stress in blood-contacting medical devices is one major factor to device-induced @entity1 . Animal blood is often used to test device-induced @entity1 potential of these devices due to its easy accessibility and low cost. However, the differences in shear-induced @entity1 between animals and @entity0 have not been well characterized. The purpose of this study was to investigate shear-induced @entity3 of @entity0 and three commonly used preclinical evaluation animal species (ovine, porcine, and @entity2 ) under shear conditions encountered in blood-contacting medical devices. Shear-induced @entity3 experiments were conducted using two single-pass blood-shearing devices. Driven by an externally pressurized reservoir, blood single-passes through a small annular gap in the shearing devices where the blood was exposed to a uniform high shear stress. Shear-induced @entity3 at different conditions of exposure time (0.04 to 1.5   s) and shear stress (25 to 320   Pa) was quantified for ovine, porcine, @entity2 , and @entity0 blood, respectively. Within these ranges of shear stress and exposure time, shear-induced @entity3 was less than 2% for the four species. The results showed that the ovine blood was more susceptible to shear-induced injury than the @entity2 , porcine, and @entity0 blood. The response of the porcine and @entity2 blood to shear was similar to the @entity0 blood. The dependence of @entity3 on shear stress level and exposure time was found to fit well the power law functional form for the four species. The coefficients of the power law models for the ovine, porcine, @entity2 , and @entity0 blood were derived.

title: Shear-Induced XXXX : Species Differences.

answer: @entity3


abstract: BACKGROUND: Methodological guidelines for intervention reporting emphasise describing intervention content in detail. Despite this, systematic reviews of quality improvement (QI) implementation interventions continue to be limited by a lack of clarity and detail regarding the intervention content being evaluated. We aimed to apply the recently developed Behaviour Change Techniques Taxonomy version 1 (BCTTv1) to trials of implementation interventions for managing @entity1 to assess the capacity and utility of this taxonomy for characterising active ingredients. METHODS: Three psychologists independently coded a random sample of 23 trials of healthcare system, provider- and/or @entity0 -focused implementation interventions from a systematic review that included 142 such studies. Intervention content was coded using the BCTTv1, which describes 93 behaviour change techniques (BCTs) grouped within 16 categories. We supplemented the generic coding instructions within the BCTTv1 with decision rules and examples from this literature. RESULTS: Less than a quarter of possible BCTs within the BCTTv1 were identified. For implementation interventions targeting providers, the most commonly identified BCTs included the following: adding objects to the environment, prompts/cues, instruction on how to perform the behaviour, credible source, goal setting (outcome), feedback on outcome of behaviour, and social support (practical). For implementation interventions also targeting @entity0 , the most commonly identified BCTs included the following: prompts/cues, instruction on how to perform the behaviour, information about health consequences, restructuring the social environment, adding objects to the environment, social support (practical), and goal setting (behaviour). The BCTTv1 mapped well onto implementation interventions directly targeting clinicians and @entity0 and could also be used to examine the impact of system-level interventions on clinician and @entity0 behaviour. CONCLUSIONS: The BCTTv1 can be used to characterise the active ingredients in trials of implementation interventions and provides specificity of content beyond what is given by broader intervention labels. Identification of BCTs may provide a more helpful means of accumulating knowledge on the content used in trials of implementation interventions, which may help to better inform replication efforts. In addition, prospective use of a behaviour change techniques taxonomy for developing and reporting intervention content would further aid in building a cumulative science of effective implementation interventions.

title: Using a behaviour change techniques taxonomy to identify active ingredients within trials of implementation interventions for XXXX care.

answer: @entity1


abstract: UNASSIGNED: BACKGROUND @entity4 are the most common primary @entity5 and are closely associated with @entity3 . @entity2 typically arise from the interatrial septum at the border of the fossa ovalis in the left atrium. Any other location is considered atypical. @entity3 , one of the complications of @entity4 , is associated with high morbidity and mortality. The aim of this study was to investigate the risk factors for @entity3 in @entity0 with @entity2 . MATERIAL AND METHODS In this retrospective study, a cohort of 162 @entity0 with @entity2 was surgically treated between January 1998 and June 2014 at 3 cardiac centers in China. Preoperative data, including platelet count, sex, age, and the @entity1 (size, location, surface, and attachment), were compared between embolic and non-embolic groups of @entity0 . RESULTS No significant differences in vascular risk factors were seen between the 2 groups. However, the percentage of higher platelet count (>300*10^9/L) and mean platelet volume in the embolic group were significantly higher than in the non-embolic group (P=0.0356, and 0.0113, respectively). Irregular surface and atypical location of the @entity4 were also independently associated with increased risk of @entity3 . CONCLUSIONS @entity1 location, macroscopic appearance, mean platelet volume, and high platelet count are strong risk factors for @entity3 in @entity0 with @entity2 .

title: Risk Factors for XXXX : A Retrospective Analysis.

answer: @entity2


abstract: OBJECTIVE: @entity3 titration may be difficult in older individuals as they are more sensitive to side effects. The current study extends to 6   months our previously published report in which @entity3 was started at 2.5   mg/day and slowly increased by 2.5   mg on alternate days (slow titration) or rapidly titrated to target dose from 10   mg/day (standard titration) in a naturalistic setting. METHODS: Here, the follow-up period was extended to 26   weeks. We performed an intent-to-treat analysis of 47 subjects from the original sample (major @entity2 and/or @entity1 ( @entity1 ); >60   years of age). Missing evaluations were replaced by last observations carried forward. @entity1 was included as a stratification factor. RESULTS: @entity0 in whom @entity3 was slowly up-titrated were more likely to remit (84.0% vs 54.5%; p   =   0.028) and had lower core @entity2 (p   =   0.0015) and @entity1 (p   =   0.006) after 26   weeks. Dropout rate was 20% in the slow titration group compared with 77.3% in the standard titration arm (p   <   0.001). @entity0 with @entity1 accounted for all significant associations. No substantial differences were reported between slow and standard titration groups in the subsample without @entity1 . CONCLUSIONS: Despite some limitations, these findings suggest that @entity3 treatment should be started at lower doses in older @entity2 @entity0 and slowly up-titrated. This strategy would allow to increase antidepressant response and the likelihood of completing treatment cycle in @entity0 with high anxiety levels and @entity1 comorbidity. Copyright    2015 John Wiley _ Sons, Ltd.

title: Persistent benefits of slow titration of XXXX in a six-month follow-up.

answer: @entity3


abstract: Intraductal @entity6 (IPMNs) of the pancreas are classified into the following four histopathologic subtypes: gastric, intestinal, pancreatobiliary, and oncocytic. However, the clinicopathologic characteristics of IPMN subtypes have not been fully clarified. Recently, a subgroup classification of @entity4 ( @entity4 ) was suggested in contrast to overt @entity0 from IPMCs (IC-IPMCs). The purpose of this study was to determine whether or not the pathologic subtype classification can predict prognosis and to validate the usefulness of the newly proposed diagnostic criteria of @entity4 . We reviewed the clinicopathologic characteristics of 142 surgically resected cases of IPMNs. There were 54, 56, 30, and two cases of the gastric, intestinal, pancreatobiliary, and oncocytic types of IPMNs, respectively. The intestinal and pancreatobiliary types were more likely to have a main duct type. All @entity2 were @entity3 or @entity7 , whereas greater than one half of the @entity5 in situ or invasive @entity0 . A significant difference in recurrence and @entity1 rate was noted for @entity0 between the intestinal and pancreatobiliary types. The majority of @entity4 were the intestinal type, whereas the majority of IC-IPMCs were the pancreatobiliary type. The IC-IPMC group showed a decreased recurrence-free and overall survival with statistically significance (p < 0.001 and p = 0.001, respectively). Our results suggest that the pathologic subtype classification and the newly proposed diagnostic criteria for minimal invasion may also be useful to predict prognosis of IPMNs of the pancreas.

title: Prognostic relevance of pathologic subtypes and minimal invasion in XXXX of the pancreas.

answer: @entity6


abstract: BACKGROUND: Nonoperative management (NOM) of solid organ injury after @entity2 is now standard. Recently, angioembolization (AE) has been used to extend NOM. Few data exist on evaluating NOM of blunt @entity1 (BRIs). We sought to determine the overall efficacy of NOM as well as the outcome of AE in @entity0 with BRI. METHODS: The trauma registry was used to identify all @entity0 with BRI between January 2002 and December 2008. Medical records were reviewed for demographics, grade of injury, use of angiographic intervention, and outcome. RESULTS: A total of 434 @entity0 with BRI were identified, 416 of whom had planned NOM; 337 (81%) @entity0 were successfully managed without further intervention for their BRI. In all, 79 (19%) @entity0 underwent angiography; 22 (27.8%) of these @entity0 underwent AE, and 6 (27.2%) failed 1.2    0.8 days after AE. @entity0 who failed AE had a significantly higher blood transfusion requirement during the first 24 h of admission (p = 0.01). Seven @entity0 not embolized failed 1.9    1.9 days after angiography. Thus, of the 79 @entity0 having angiography, 13 (16.5%) failed and required laparotomy to treat their BRIs. Overall failure rate of NOM was 3.1% (13/416). @entity0 who failed angiography, with or without AE, required more blood during the first 24 h after admission (p = 0.03). CONCLUSIONS: NOM of BRI is safe and effective, with an overall failure rate of 3.1%. However, angiography with or without AE has substantial failure rates. @entity0 with higher-grade injuries and active vascular extravasation on admission computed tomography scan also fail NOM regardless of therapy. The blood transfusion requirement during the first 24 h may indicate who will require operative intervention following angiography. Close observation and/or early laparotomy are wise for these high-risk @entity0 .

title: Angiointervention: high rates of failure following blunt XXXX .

answer: @entity1


abstract: OBJECTIVES: @entity7 remain the most important cause of morbidity and mortality in liver transplant recipients. Fast and accurate causative diagnoses are essential for a good outcome. Bronchoscopy with bronchoalveolar lavage frequently is performed to diagnose @entity4 in immunocompromised @entity0 . The aim of this study was to evaluate the diagnostic use of bronchoalveolar lavage in liver transplant recipients with @entity4 . MATERIALS AND METHODS: We retrospectively analyzed the data of 408 @entity0 who underwent liver transplant from January 1990 to December 2012. @entity0 who underwent bronchoalveolar lavage after transplant were included in this study. RESULTS: There were 18 of 408 liver transplant recipients (4.41%) who underwent bronchoalveolar lavage after transplant. The mean age was 49.5    18 years. In 5 @entity0 (27.8%), fungal microorganisms were observed in the cytology of bronchoalveolar lavage specimens, including @entity1 in 3 @entity0 and @entity6 in 2 @entity0 . @entity2 occurred in 4 of 5 @entity0 (80%) with @entity5 . No association was observed between the presence of @entity5 and clinical and radiographic findings of the @entity0 . CONCLUSIONS: Bronchoscopy with bronchoalveolar lavage is a useful, noninvasive diagnostic tool for the rapid diagnosis of @entity3 in solid-organ transplant recipients.

title: Role of bronchoalveolar lavage in diagnosis of XXXX in liver transplant recipients.

answer: @entity5


abstract: UNASSIGNED: This study investigates symptom relief in @entity0 whose @entity2 ( @entity2 ) were completely relieved following microvascular decompression (MVD). @entity0 with @entity2 who were operated on from January 2007 to May 2011, at our department, were studied. The medical records and operation videos of each @entity0 were reviewed. Follow-up was performed via telephone communication. A total of 410 @entity0 with @entity2 were divided into two groups: Group A (277 cases): @entity2 caused by @entity4 , and Group B (133 cases): @entity2 caused by vertebral artery compression. Magnetic resonance imaging (MRI) was performed on all the @entity0 to rule out those with secondary @entity2 . @entity0 who had undergone previous MVD were also excluded at that time. In all, 462 @entity0 underwent MVD for @entity2 in our center during the study period. Follow-up was available for 410 @entity0 . In the @entity4 cohort, 72 (72/277, 26.0  %) @entity2 @entity0 achieved relief with @entity1 . While in the vertebral artery compression cohort, 52 (52/133, 39.1  %) @entity2 @entity0 experienced relief with @entity1 . There was significant difference between these two cohorts (P  <  0.05). 93.75% of @entity1 @entity0 were cured and experienced @entity3 relief within 6  months. Surgeons should be aware that delayed symptom relief after MVD for @entity2 is more common than has been reported, and time course of symptom relief is various as well as unpredictable; however, most @entity2 @entity0 are cured, and experience @entity3 relief within 6  months.

title: Clinical analysis of hemifacial XXXX @entity0 with delay symptom relief after microvascular decompression of distinct offending vessels.

answer: @entity3


abstract: UNASSIGNED: This study investigates symptom relief in @entity0 whose @entity2 ( @entity2 ) were completely relieved following microvascular decompression (MVD). @entity0 with @entity2 who were operated on from January 2007 to May 2011, at our department, were studied. The medical records and operation videos of each @entity0 were reviewed. Follow-up was performed via telephone communication. A total of 410 @entity0 with @entity2 were divided into two groups: Group A (277 cases): @entity2 caused by @entity4 , and Group B (133 cases): @entity2 caused by vertebral artery compression. Magnetic resonance imaging (MRI) was performed on all the @entity0 to rule out those with secondary @entity2 . @entity0 who had undergone previous MVD were also excluded at that time. In all, 462 @entity0 underwent MVD for @entity2 in our center during the study period. Follow-up was available for 410 @entity0 . In the @entity4 cohort, 72 (72/277, 26.0  %) @entity2 @entity0 achieved relief with @entity1 . While in the vertebral artery compression cohort, 52 (52/133, 39.1  %) @entity2 @entity0 experienced relief with @entity1 . There was significant difference between these two cohorts (P  <  0.05). 93.75% of @entity1 @entity0 were cured and experienced @entity3 relief within 6  months. Surgeons should be aware that delayed symptom relief after MVD for @entity2 is more common than has been reported, and time course of symptom relief is various as well as unpredictable; however, most @entity2 @entity0 are cured, and experience @entity3 relief within 6  months.

title: Clinical analysis of hemifacial @entity3 XXXX with delay symptom relief after microvascular decompression of distinct offending vessels.

answer: @entity0


abstract: PURPOSE: To evaluate the differential CT features of gastric @entity1 ( @entity1 ) from well-differentiated NETs (WD-NETs) and @entity2 ( @entity3 ) and to suggest differential features of hepatic metastases from gastric NETs and @entity3 . MATERIALS AND METHODS: Our study population was comprised of 36 @entity0 with gastric NETs (18 WD-NETs, 18 @entity1 ) and 38 @entity0 with gastric @entity3 who served as our control group. Multiple CT features were assessed to identify significant differential CT findings of @entity1 from WD-NETs and @entity3 . In addition, CT features of hepatic metastases including the metastasis-to-liver ratio were analyzed to differentiate metastatic NETs from @entity3 . RESULTS: The presence of metastatic lymph nodes was the sole differentiator of @entity1 from WD-NETs (P   =   .001, odds ratio   =   56.67), while the presence of intact overlying mucosa with mucosal tenting was the sole significant CT feature differentiating @entity1 from @entity3 (P   =   .047, odds ratio   =   15.3) For hepatic metastases, metastases from NETs were more hyper-attenuated than those from @entity3 . CONCLUSION: The presence of metastatic LNs and intact overlying mucosa with mucosal tenting are useful CT discriminators of @entity1 from WD-NETs and @entity3 , respectively. In addition, a higher metastasis-to-liver ratio may help differentiate hepatic metastases of gastric NETs from those of gastric @entity3 with high accuracy. KEY POINTS:     Presence of metastatic LNs is a useful differentiator of @entity1 from WD-NETs.     Intact overlying mucosa with mucosal tenting suggests @entity1 more than gastric @entity3 .     Metastatic LNs are larger in size and greater in necrotic volume in @entity1 .     Hepatic metastases from gastric NETs are more hyper-attenuated than those from @entity3 .

title: CT differentiation of poorly-differentiated @entity1 from well-differentiated @entity1 and XXXX .

answer: @entity2


abstract: PURPOSE: To evaluate the differential CT features of gastric @entity1 ( @entity1 ) from well-differentiated NETs (WD-NETs) and @entity2 ( @entity3 ) and to suggest differential features of hepatic metastases from gastric NETs and @entity3 . MATERIALS AND METHODS: Our study population was comprised of 36 @entity0 with gastric NETs (18 WD-NETs, 18 @entity1 ) and 38 @entity0 with gastric @entity3 who served as our control group. Multiple CT features were assessed to identify significant differential CT findings of @entity1 from WD-NETs and @entity3 . In addition, CT features of hepatic metastases including the metastasis-to-liver ratio were analyzed to differentiate metastatic NETs from @entity3 . RESULTS: The presence of metastatic lymph nodes was the sole differentiator of @entity1 from WD-NETs (P   =   .001, odds ratio   =   56.67), while the presence of intact overlying mucosa with mucosal tenting was the sole significant CT feature differentiating @entity1 from @entity3 (P   =   .047, odds ratio   =   15.3) For hepatic metastases, metastases from NETs were more hyper-attenuated than those from @entity3 . CONCLUSION: The presence of metastatic LNs and intact overlying mucosa with mucosal tenting are useful CT discriminators of @entity1 from WD-NETs and @entity3 , respectively. In addition, a higher metastasis-to-liver ratio may help differentiate hepatic metastases of gastric NETs from those of gastric @entity3 with high accuracy. KEY POINTS:     Presence of metastatic LNs is a useful differentiator of @entity1 from WD-NETs.     Intact overlying mucosa with mucosal tenting suggests @entity1 more than gastric @entity3 .     Metastatic LNs are larger in size and greater in necrotic volume in @entity1 .     Hepatic metastases from gastric NETs are more hyper-attenuated than those from @entity3 .

title: CT differentiation of poorly-differentiated XXXX from well-differentiated @entity1 and @entity2 .

answer: @entity1


abstract: PURPOSE: To evaluate the differential CT features of gastric @entity1 ( @entity1 ) from well-differentiated NETs (WD-NETs) and @entity2 ( @entity3 ) and to suggest differential features of hepatic metastases from gastric NETs and @entity3 . MATERIALS AND METHODS: Our study population was comprised of 36 @entity0 with gastric NETs (18 WD-NETs, 18 @entity1 ) and 38 @entity0 with gastric @entity3 who served as our control group. Multiple CT features were assessed to identify significant differential CT findings of @entity1 from WD-NETs and @entity3 . In addition, CT features of hepatic metastases including the metastasis-to-liver ratio were analyzed to differentiate metastatic NETs from @entity3 . RESULTS: The presence of metastatic lymph nodes was the sole differentiator of @entity1 from WD-NETs (P   =   .001, odds ratio   =   56.67), while the presence of intact overlying mucosa with mucosal tenting was the sole significant CT feature differentiating @entity1 from @entity3 (P   =   .047, odds ratio   =   15.3) For hepatic metastases, metastases from NETs were more hyper-attenuated than those from @entity3 . CONCLUSION: The presence of metastatic LNs and intact overlying mucosa with mucosal tenting are useful CT discriminators of @entity1 from WD-NETs and @entity3 , respectively. In addition, a higher metastasis-to-liver ratio may help differentiate hepatic metastases of gastric NETs from those of gastric @entity3 with high accuracy. KEY POINTS:     Presence of metastatic LNs is a useful differentiator of @entity1 from WD-NETs.     Intact overlying mucosa with mucosal tenting suggests @entity1 more than gastric @entity3 .     Metastatic LNs are larger in size and greater in necrotic volume in @entity1 .     Hepatic metastases from gastric NETs are more hyper-attenuated than those from @entity3 .

title: CT differentiation of poorly-differentiated @entity1 from well-differentiated XXXX and @entity2 .

answer: @entity1


abstract: Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and @entity1 . One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome ( @entity7 /C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the @entity7 /C is essential for cell cycle progression it is also expressed in postmitotic neurons where it has been implicated with axonal outgrowth and neuronal survival. In this study we addressed the role of @entity7 /C in learning and memory function by generating @entity0 that lack the essential subunit @entity8 from excitatory neurons of the adult forebrain. Those animals are viable but exhibit a severe impairment in the ability to extinct fear memories, a process critical for the treatment of @entity2 such as @entity5 or @entity6 . Since deregulated protein degradation and @entity7 /C activity has been implicated with @entity3 we also analyzed the effect of @entity8 deletion in a @entity0 model for @entity4 . In our experimental setting loss of @entity8 form principle forebrain neurons did not affect the course of pathology in an @entity4 @entity0 model. In conclusion, our data provides genetic evidence that @entity7 /C activity in the adult forebrain is required for cognitive function.

title: The anaphase promoting complex is required for memory function in XXXX .

answer: @entity0


abstract: UNASSIGNED: Distal symmetric @entity2 (DSPN), the most common form of @entity5 , has a complex pathophysiology and can be a major source of physical and @entity3 . The management of DSPN can be frustrating for both @entity0 and physician. This article provides a general overview of typical @entity0 pathways in DSPN, and highlights variations in diagnosis, management, and referral patterns among different providers. DSPN is managed in several settings by primary care physicians (PCPs), specialists, and nurse practitioners. The initial clinical management of the @entity0 is often dependent on the presenting complaint, the referral pattern of the provider, level of comfort of the PCP in managing @entity4 , and geographic access to specialists. The primary treatment of DSPN focuses mainly on glycemic control and adjustment of modifiable risk factors, but other causes of @entity1 should also be investigated. Several pharmacologic agents are recommended by treatment guidelines, and as DSPN typically exists with comorbid conditions, a multimodal therapeutic approach should be considered. Barriers to effective management include failure to recognize DSPN, and misdiagnosis. @entity0 education also remains important. Referral patterns vary widely according to geographic location, access to services, provider preferences, and comfort in managing complex aspects of the disease. The variability in @entity0 pathways affects @entity0 education, satisfaction, and outcomes. Standardized screening tools, a multidisciplinary team approach, and treatment algorithms for @entity5 should improve future care. To improve @entity0 outcomes, DSPN needs to be diagnosed sooner and interventions made before significant nerve damage occurs.

title: Pathways in the Diagnosis and Management of XXXX .

answer: @entity5


abstract: UNASSIGNED: The rodent anterior cingulate cortex (ACC) is critical for @entity3 and @entity1 -related aversive response in chronic visceral hypersensitive (VH) state. Long-term potentiation (LTP), induced by @entity4 ( @entity4 ) in the medial thalamus (MT)-ACC pathway, is blocked in VH @entity0 . However, the neuronal intrinsic firing characteristics and the MT-ACC connectivity have not been investigated in @entity3 . Using repetitive distension of the colon and rectum (rCRD) as a sensitization paradigm, we have identified that the spontaneous firing rates of ACC neurons and the @entity2 -stimulated neuronal firings were increased after repetitive visceral noxious stimulation. This correlates with @entity3 responses (visceromotor responses, VMRs). Two multichannel arrays of electrodes were implanted in the MT and ACC. Recordings were performed in free-moving @entity0 before and after repeated @entity2 treatment. Power spectral density analysis showed that the local field potential (LFP) recorded in the ACC displayed increases in theta band power (4-10Hz) that were modulated by rCRD. Neural spike activity in the ACC becomes synchronized with ongoing theta oscillations of LFP. Furthermore, cross correlation analysis showed augmented synchronization of thalamo-ACC theta band LFPs, which was consistent with an increase of neuronal communication between the two regions. In conclusion, these results reveal theta oscillations and theta-frequency phase-locking as prominent features of neural activity in the ACC and a candidate neural mechanism underlying acute @entity3 .

title: Theta-frequency phase-locking of single anterior cingulate cortex neurons and synchronization with the medial thalamus are modulated by visceral noxious stimulation in XXXX .

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Epidural catheters placed for perioperative @entity2 in young @entity0 confer clinical benefits but are technically challenging to insert. Approximations of the skin to epidural space depth in this population are limited to direct needle measurement and ultrasonography. Magnetic resonance imaging (MRI) is the most comprehensive imaging modality of the spine. This study aims to produce a more clinically useful formula from MRI data to estimate pediatric @entity1 . METHODS: Seventy @entity0 with normal lumbar spine MR images were enrolled. After @entity1 , linear regression was used to estimate a weight-based formula. Analysis of variance and bootstrap methods were used to evaluate this formula against 4 commonly cited formulae. The quality of predictions was evaluated using the mean absolute prediction error. RESULTS: The estimated weight-based formula as derived by MRI data is given by: skin to @entity1 (mm) = 9.00 + 0.62 * weight in kilograms. The mean absolute prediction error was 2.56 mm (95% confidence interval [95% CI], 2.12-3.04) for the new formula. Additional derived formulae are skin to dorsal dura depth (mm) = 13.52 + 0.71 * weight in kilograms (mean absolute prediction error, 2.48 mm; 95% CI, 2.00-3.03) and skin to ventral dural depth (mm) = 23.08 + 0.86 * weight in kilograms (mean absolute prediction error, 2.50 mm; 95% CI, 2.04-3.06). CONCLUSIONS: We provide the first predictive formulae, based on MRI data, for pediatric @entity1 estimation.

title: Evaluation of the skin to epidural and subarachnoid space distance in young XXXX using magnetic resonance imaging.

answer: @entity0


abstract: OBJECTIVES: Several studies have found a significant association between the presence of earlobe crease (ELC) and @entity0 ( @entity0 ). Brachial-ankle Pulse Wave Velocity (baPWV) is a non-invasive and useful measure of arterial stiffness predicting @entity0 and mortality. However, few studies have reported the relationship between ELC and baPWV as a new measure of arterial stiffness. The purpose of this study was to determine whether ELC is related to baPWV in non-diabetic, non- @entity1 , and apparently healthy Korean adults. METHODS: A cross-sectional study was conducted on 573 non- @entity1 , non-diabetic Korean adults aged 20-80 yr. Subjects were stratified into three groups according to gender and menopausal status. baPWV was measured by an automatic waveform analyser. The association between ELC and baPWV was assessed by multiple linear regression analysis after adjusting for conventional @entity0 risk factors including age, gender, blood pressure, lipid profile, and smoking status etc. RESULTS: The overall frequency of ELC was 19.02% and the subjects with ELC showed significantly higher mean baPWV (p<0.0001). Multiple linear regression of subjects revealed that the presence of ELC was independently associated with baPWV (male, p<0.0001; premenopausal female p=0.0162; postmenopausal female p=0.0208). CONCLUSION: ELC had a significant correlation with baPWV, independently controlling for other classical cardiovascular risk factors in adults aged 20 yr or older. ELC is an important surrogate marker of increased arterial stiffness as measured by baPWV in Korean adults.

title: Relationship Between Earlobe Crease and Brachial-ankle Pulse Wave Velocity in XXXX in Korea.

answer: @entity1


abstract: UNASSIGNED: @entity2 ( @entity3 ) has been widely studied due to its global distribution, slow degradation, high bioaccumulation and toxicological effects on vertebrates. However, the potential @entity0 of @entity3 to crustaceans is little known. The present study investigated the effects of @entity3 on the immune responses and expression of immune-related genes in the Chinese mitten-handed crab @entity4 . Crabs were exposed to 0, 0.01, 0.1, 1.0 and 10mg/L of @entity3 , and sampled on 1, 4, 7, 14 and 21days respectively. The total hemocyte count and lysozyme activity in @entity3 -treated crab were significantly lower than in the control. The exposure to 10mg/L of @entity3 led to a marked inhibition in phenoloxidase and @entity1 dismutase activities. At other @entity3 levels, phenoloxidase and @entity1 dismutase showed an initial increase and a subsequent decrease over time. The alkaline and acid phosphatase activities were stimulated in 10mg/L @entity3 until 21days. The mRNA expression of immune related genes including hepatopancreas-specific C-type lectin and prophenoloxidase activating factors were up-regulated after the exposure to the concentrations of 1 and 10mg/L of @entity3 , while the expression of lysozyme gene was up-regulated only in the crab exposed to 0.1mg/L @entity3 . The results demonstrate that the high dose of @entity3 leads to immune @entity0 and the hepatopancreas is a major target organ for @entity3 accumulation and immunotoxicity. Hemocyte counts, phenoloxidase and acid phosphatase are useful biomarkers for the risk assessment of @entity3 @entity0 to crustaceans.

title: Effects of XXXX on the immune responses and expression of immune-related genes in Chinese mitten-handed crab @entity4 .

answer: @entity2


abstract: UNASSIGNED: @entity2 ( @entity3 ) has been widely studied due to its global distribution, slow degradation, high bioaccumulation and toxicological effects on vertebrates. However, the potential @entity0 of @entity3 to crustaceans is little known. The present study investigated the effects of @entity3 on the immune responses and expression of immune-related genes in the Chinese mitten-handed crab @entity4 . Crabs were exposed to 0, 0.01, 0.1, 1.0 and 10mg/L of @entity3 , and sampled on 1, 4, 7, 14 and 21days respectively. The total hemocyte count and lysozyme activity in @entity3 -treated crab were significantly lower than in the control. The exposure to 10mg/L of @entity3 led to a marked inhibition in phenoloxidase and @entity1 dismutase activities. At other @entity3 levels, phenoloxidase and @entity1 dismutase showed an initial increase and a subsequent decrease over time. The alkaline and acid phosphatase activities were stimulated in 10mg/L @entity3 until 21days. The mRNA expression of immune related genes including hepatopancreas-specific C-type lectin and prophenoloxidase activating factors were up-regulated after the exposure to the concentrations of 1 and 10mg/L of @entity3 , while the expression of lysozyme gene was up-regulated only in the crab exposed to 0.1mg/L @entity3 . The results demonstrate that the high dose of @entity3 leads to immune @entity0 and the hepatopancreas is a major target organ for @entity3 accumulation and immunotoxicity. Hemocyte counts, phenoloxidase and acid phosphatase are useful biomarkers for the risk assessment of @entity3 @entity0 to crustaceans.

title: Effects of @entity2 on the immune responses and expression of immune-related genes in Chinese mitten-handed crab XXXX .

answer: @entity4


abstract: Analysis of variance (ANOVA) and symmetric differences squared ( @entity0 ) methods for estimating genetic and environmental variances and covariances associated with beef @entity1 weaning weight were compared via simulation. Simulation was based on the pedigree and record structure of 503 beef weaning weights collected over 19 yr from a university herd. The @entity0 methodology was used with four models. The simplest model included direct (g) and maternal (gm) additive genetic effects, genetic covariance between direct and maternal additive genetic effects (sigma ggm), permanent maternal environmental effects (m) and temporary environmental effects (e). The second model also allowed for a nonzero environmental covariance (sigma mem) between dam and offspring weaning weights. Models 3 and 4 were models 1 and 2, respectively, expanded to include a grandmaternal genetic effect (gn) and covariances sigma ggn and sigma gmgn. Two ANOVA solution sets for the parameters of model 4 were obtained using sire, dam, maternal grandsire, maternal grandam and phenotypic variances and offspring-dam (covOD), offspring-sire (covOS), offspring-grandam (covOGD), and offspring-maternal half-aunt or uncle (covOMH) covariances. Four ANOVA solution sets for the parameters of model 2 were obtained using sire, dam, within dam and maternal grandsire variances, covOD and either covOS or covOGD. Two sets of 1,000 replicates of the data were simulated. These data were used to compare precision and accuracy of @entity0 and ANOVA estimators, to estimate correlations among @entity0 and ANOVA estimators, and to study the importance of taking inbreeding into account with @entity0 methodology. All ANOVA estimators for rho ggm were biased downward. The @entity0 procedure had a clear advantage over ANOVA. Averages of @entity0 estimates were closer to parameter values used to simulate the data and their standard deviations were generally smaller. The standard deviations of both @entity0 and ANOVA estimates of rho ggm were very large. It is important to allow for a nonzero sigma mem (at least when it is negative) when using @entity0 methods; otherwise estimators of sigma 2gm and sigma ggm are biased upward and downward, respectively.

title: Symmetric differences squared and analysis of variance procedures for estimating genetic and environmental variances and covariances for beef XXXX weaning weight: I. Comparison via simulation.

answer: @entity1


abstract: The principal mechanism of cellular uptake of @entity3 and other @entity1 ( @entity2 ) from lipoproteins into cells is spontaneous transfer through the aqueous phase (Plant, A. L., Benson, D.M., and Smith, L.C. (1985) J. Cell Biol. 100, 1295-1308). Cellular uptake of @entity3 from low density lipoproteins followed first-order kinetics with a rate constant that was independent of the relative lipoprotein concentrations or cell number but which was 2 orders of magnitude smaller than the rate constant for @entity3 desorption from low density lipoproteins. Moreover, identical rate constants for cellular uptake of @entity3 were observed when the donor vehicle was high density lipoproteins, very low density lipoproteins, or single bilayer @entity0 vesicles, even though rate constants for @entity3 transfer from these donor vehicles differed by 10-fold. When @entity0 vesicles containing @entity3 and a nontransferable fluorescence quencher were mixed with cells in a stopped-flow system, two kinetic components were distinguished: a fast component with a rate constant corresponding to that measured for transfer of @entity3 out of vesicles, followed by a much slower component, with a time course approximating that measured for cellular accumulation of @entity3 by other techniques. Rate constants for desorption of a series of @entity2 which contained different number of aromatic rings from @entity0 vesicles differed over a 70-fold range. First-order rate constants for cell uptake of @entity3 and five other @entity2 of different molecular sizes had the same 70-fold range of values, but were 2 orders of magnitude smaller than their respective rate constants for desorption from single bilayer vesicles. In addition, activation energies for cell uptake were essentially identical to the respective activation energies for desorption of @entity2 from @entity0 vesicles, confirming the mechanistic similarity of the two processes.

title: Mechanism and rate of permeation of cells by XXXX .

answer: @entity1


abstract: Aims. To explore the effects and mechanisms of fluid shear stress on portal vein remodeling in a @entity0 model of @entity1 . Methods. Subcutaneous injections of @entity9 were given to establish a @entity0 model of @entity4 and @entity1 . Biomechanical technology was adopted to determine the dynamic changes of haemodynamic indices and fluid shear stress. @entity2 (NO), synthase (NOS), and @entity7 ( @entity7 ) of the portal vein blood were measured. Changes in geometric structure and ultrastructure of the portal vein were observed using optical and electron microscopy. Results. After the CC14 injections, @entity0 haemodynamics were notably altered. From week 4 onwards, @entity8 , PVF, and PVR gradually and significantly increased (P < 0.05 versus baseline). The fluid shear stress declined from week 4 onwards (P < 0.01 versus control group). NO, NOS, and @entity7 increased after repeated CCI4 injections. @entity5 and @entity6 staining showed thickened portal vein walls, with increased inside and outside diameters. Electron microscopy revealed different degrees of endothelial cell degeneration, destruction of basement membrane integrity, proliferating, and @entity3 smooth muscle cells. Conclusions. Fluid shear stress not only influenced the biomechanical environment of the portal vein but also participated in vascular remodeling.

title: Effect of fluid shear stress on portal vein remodeling in a @entity0 model of XXXX .

answer: @entity1


abstract: Aims. To explore the effects and mechanisms of fluid shear stress on portal vein remodeling in a @entity0 model of @entity1 . Methods. Subcutaneous injections of @entity9 were given to establish a @entity0 model of @entity4 and @entity1 . Biomechanical technology was adopted to determine the dynamic changes of haemodynamic indices and fluid shear stress. @entity2 (NO), synthase (NOS), and @entity7 ( @entity7 ) of the portal vein blood were measured. Changes in geometric structure and ultrastructure of the portal vein were observed using optical and electron microscopy. Results. After the CC14 injections, @entity0 haemodynamics were notably altered. From week 4 onwards, @entity8 , PVF, and PVR gradually and significantly increased (P < 0.05 versus baseline). The fluid shear stress declined from week 4 onwards (P < 0.01 versus control group). NO, NOS, and @entity7 increased after repeated CCI4 injections. @entity5 and @entity6 staining showed thickened portal vein walls, with increased inside and outside diameters. Electron microscopy revealed different degrees of endothelial cell degeneration, destruction of basement membrane integrity, proliferating, and @entity3 smooth muscle cells. Conclusions. Fluid shear stress not only influenced the biomechanical environment of the portal vein but also participated in vascular remodeling.

title: Effect of fluid shear stress on portal vein remodeling in a XXXX model of @entity1 .

answer: @entity0


abstract: BACKGROUND: A significant body @entity1 (BWL) is observed during 1  month after gastrectomy for @entity2 . However, it remains unclear which body component mainly accounts for the @entity1 . METHODS: Two-hundred forty-four @entity0 who underwent gastrectomy for @entity2 between May 2010 and October 2013 were examined. Body weight and composition were evaluated by a bioelectrical impedance analyzer within 1  week before surgery (first measurement), at 1  week after surgery (second measurement), and at 1  month after surgery (third measurement). The changes in the early period were defined as the differences until the second measurement, and those in the late period were defined as the differences from the second to the third measurement. RESULTS: Total BWL within 1  month was -3.4  kg, and the rate of body weight at 1  month to the preoperative body weight was 94.1  %. BWL was significantly greater in the early period than in the late period (-2.1  kg vs -1.2  kg, p  <  0.001). In the early period, loss of lean body mass was significantly greater than loss of fat mass (-1.5  kg vs -0.6  kg, p  <  0.001). The same trend was observed when the subset of @entity0 who had surgical morbidities was excluded. CONCLUSION: BWL during the first week after surgery was significantly greater than that during the subsequent 3  weeks. Furthermore, loss of lean body mass accounted for a significant part of the BWL during the first week.

title: Body composition analysis within 1  month after gastrectomy for XXXX .

answer: @entity2


abstract: OBJECTIVE: Studies have confirmed that @entity0 with circulating @entity1 cells (CTCs) in their peripheral blood (PB) or disseminated @entity1 cells (DTCs) in bone marrow (BM) might have bad prognosis. In this paper, we discuss whether CTCs/DTCs would be an appropriate biomarker to predict the prognosis of @entity2 . METHODS: We systematically searched PubMed, EMBASE, Cochrane library, and Chinese National Knowledge Infrastructure to collect relevant studies published from the time the database were created to February 2014. Studies quality was assessed by Newcastle-Ottawa Scale. The effect size was estimated by hazard ratio (HR) and corresponding 95% confidence interval (95% CI). Meta-analysis was conducted with STATA Version 12.0. RESULTS: Eight studies of 1184 @entity0 were included in the final analysis. In the PB group, it showed that @entity0 with positive CTCs had significantly shorter overall survival and disease-free survival than @entity0 with negative CTCs (HR, 2.09; CI, 1.13-3.88 and HR, 1.72; CI, 1.32-2.25, respectively). The same result was shown with DTCs in the BM group (HR, 1.61; CI, 1.27-2.04 and HR, 1.44; CI, 1.15-1.80, respectively). We also discussed the influence of CTCs/DTCs on International Federation of Gynecology and Obstetrics stage, pathological grade with odds ratio and 95% CI. However, it did not show any statistical significance. CONCLUSIONS: The CTCs/DTCs might be a new biomarker to predict the prognosis of @entity2 . Future studies are needed to confirm this consequence.

title: The Predictive Value of Circulating XXXX Cells in @entity2 : A Meta Analysis.

answer: @entity1


abstract: OBJECTIVE: Studies have confirmed that @entity0 with circulating @entity1 cells (CTCs) in their peripheral blood (PB) or disseminated @entity1 cells (DTCs) in bone marrow (BM) might have bad prognosis. In this paper, we discuss whether CTCs/DTCs would be an appropriate biomarker to predict the prognosis of @entity2 . METHODS: We systematically searched PubMed, EMBASE, Cochrane library, and Chinese National Knowledge Infrastructure to collect relevant studies published from the time the database were created to February 2014. Studies quality was assessed by Newcastle-Ottawa Scale. The effect size was estimated by hazard ratio (HR) and corresponding 95% confidence interval (95% CI). Meta-analysis was conducted with STATA Version 12.0. RESULTS: Eight studies of 1184 @entity0 were included in the final analysis. In the PB group, it showed that @entity0 with positive CTCs had significantly shorter overall survival and disease-free survival than @entity0 with negative CTCs (HR, 2.09; CI, 1.13-3.88 and HR, 1.72; CI, 1.32-2.25, respectively). The same result was shown with DTCs in the BM group (HR, 1.61; CI, 1.27-2.04 and HR, 1.44; CI, 1.15-1.80, respectively). We also discussed the influence of CTCs/DTCs on International Federation of Gynecology and Obstetrics stage, pathological grade with odds ratio and 95% CI. However, it did not show any statistical significance. CONCLUSIONS: The CTCs/DTCs might be a new biomarker to predict the prognosis of @entity2 . Future studies are needed to confirm this consequence.

title: The Predictive Value of Circulating @entity1 Cells in XXXX : A Meta Analysis.

answer: @entity2


abstract: STUDY DESIGN: Bioinformatics analysis of published microarray data. OBJECTIVE: This study aimed to reveal the possible genes and pathways related to the pathogenesis of @entity3 by analyzing the microarray data. SUMMARY OF BACKGROUND DATA: @entity3 ( @entity3 ) is one of the main causes of @entity2 , which has become an enormous economic burden for society. METHODS: Gene expression data of annulus cells and nucleus pulposus cells from @entity3 @entity0 and controls subjects were downloaded from Gene Expression Omnibus. T-test and enrichment analysis were used to identify differentially expressed genes (DEGs) and DEGs-associated functions and pathways in @entity3 respectively. Protein-protein interaction network and module were constructed to analyze the key nodes associated with this disease. RESULTS: Totally 326 DEGs and 35 DEGs were obtained from the annulus cells and nucleus pulposus cells, respectively. The DEGs of @entity3 in annulus cells were mainly involved in translation, cell adhesion, cell death regulation and skeletal system development whilst the DEGs in nucleus pulposus cells were mainly related to the biological processes of vascular system development, skeletal system development and enzyme-linked receptor protein signaling pathway. @entity1 was the common DEGs in both annulus cells and nucleus pulposus cells. The ribosomal proteins ( @entity4 , @entity6 and @entity5 ) in module were enriched in biological processes of translation, translation elongation and RNA processing. CONCLUSION: The results revealed the involvement of @entity1 in skeletal system process and @entity4 , @entity6 and @entity5 in the protein synthesis processes in the progression of @entity3 , suggesting their potential use in the diagnosis and therapy of @entity3 .

title: Dysregulated @entity1 and @entity4 , @entity6 , XXXX in Disc Degeneration Revealed by Bioinformatics Methods.

answer: @entity5


abstract: STUDY DESIGN: Bioinformatics analysis of published microarray data. OBJECTIVE: This study aimed to reveal the possible genes and pathways related to the pathogenesis of @entity3 by analyzing the microarray data. SUMMARY OF BACKGROUND DATA: @entity3 ( @entity3 ) is one of the main causes of @entity2 , which has become an enormous economic burden for society. METHODS: Gene expression data of annulus cells and nucleus pulposus cells from @entity3 @entity0 and controls subjects were downloaded from Gene Expression Omnibus. T-test and enrichment analysis were used to identify differentially expressed genes (DEGs) and DEGs-associated functions and pathways in @entity3 respectively. Protein-protein interaction network and module were constructed to analyze the key nodes associated with this disease. RESULTS: Totally 326 DEGs and 35 DEGs were obtained from the annulus cells and nucleus pulposus cells, respectively. The DEGs of @entity3 in annulus cells were mainly involved in translation, cell adhesion, cell death regulation and skeletal system development whilst the DEGs in nucleus pulposus cells were mainly related to the biological processes of vascular system development, skeletal system development and enzyme-linked receptor protein signaling pathway. @entity1 was the common DEGs in both annulus cells and nucleus pulposus cells. The ribosomal proteins ( @entity4 , @entity6 and @entity5 ) in module were enriched in biological processes of translation, translation elongation and RNA processing. CONCLUSION: The results revealed the involvement of @entity1 in skeletal system process and @entity4 , @entity6 and @entity5 in the protein synthesis processes in the progression of @entity3 , suggesting their potential use in the diagnosis and therapy of @entity3 .

title: Dysregulated @entity1 and XXXX , @entity6 , @entity5 in Disc Degeneration Revealed by Bioinformatics Methods.

answer: @entity4


abstract: STUDY DESIGN: Bioinformatics analysis of published microarray data. OBJECTIVE: This study aimed to reveal the possible genes and pathways related to the pathogenesis of @entity3 by analyzing the microarray data. SUMMARY OF BACKGROUND DATA: @entity3 ( @entity3 ) is one of the main causes of @entity2 , which has become an enormous economic burden for society. METHODS: Gene expression data of annulus cells and nucleus pulposus cells from @entity3 @entity0 and controls subjects were downloaded from Gene Expression Omnibus. T-test and enrichment analysis were used to identify differentially expressed genes (DEGs) and DEGs-associated functions and pathways in @entity3 respectively. Protein-protein interaction network and module were constructed to analyze the key nodes associated with this disease. RESULTS: Totally 326 DEGs and 35 DEGs were obtained from the annulus cells and nucleus pulposus cells, respectively. The DEGs of @entity3 in annulus cells were mainly involved in translation, cell adhesion, cell death regulation and skeletal system development whilst the DEGs in nucleus pulposus cells were mainly related to the biological processes of vascular system development, skeletal system development and enzyme-linked receptor protein signaling pathway. @entity1 was the common DEGs in both annulus cells and nucleus pulposus cells. The ribosomal proteins ( @entity4 , @entity6 and @entity5 ) in module were enriched in biological processes of translation, translation elongation and RNA processing. CONCLUSION: The results revealed the involvement of @entity1 in skeletal system process and @entity4 , @entity6 and @entity5 in the protein synthesis processes in the progression of @entity3 , suggesting their potential use in the diagnosis and therapy of @entity3 .

title: Dysregulated XXXX and @entity4 , @entity6 , @entity5 in Disc Degeneration Revealed by Bioinformatics Methods.

answer: @entity1


abstract: STUDY DESIGN: Bioinformatics analysis of published microarray data. OBJECTIVE: This study aimed to reveal the possible genes and pathways related to the pathogenesis of @entity3 by analyzing the microarray data. SUMMARY OF BACKGROUND DATA: @entity3 ( @entity3 ) is one of the main causes of @entity2 , which has become an enormous economic burden for society. METHODS: Gene expression data of annulus cells and nucleus pulposus cells from @entity3 @entity0 and controls subjects were downloaded from Gene Expression Omnibus. T-test and enrichment analysis were used to identify differentially expressed genes (DEGs) and DEGs-associated functions and pathways in @entity3 respectively. Protein-protein interaction network and module were constructed to analyze the key nodes associated with this disease. RESULTS: Totally 326 DEGs and 35 DEGs were obtained from the annulus cells and nucleus pulposus cells, respectively. The DEGs of @entity3 in annulus cells were mainly involved in translation, cell adhesion, cell death regulation and skeletal system development whilst the DEGs in nucleus pulposus cells were mainly related to the biological processes of vascular system development, skeletal system development and enzyme-linked receptor protein signaling pathway. @entity1 was the common DEGs in both annulus cells and nucleus pulposus cells. The ribosomal proteins ( @entity4 , @entity6 and @entity5 ) in module were enriched in biological processes of translation, translation elongation and RNA processing. CONCLUSION: The results revealed the involvement of @entity1 in skeletal system process and @entity4 , @entity6 and @entity5 in the protein synthesis processes in the progression of @entity3 , suggesting their potential use in the diagnosis and therapy of @entity3 .

title: Dysregulated @entity1 and @entity4 , XXXX , @entity5 in Disc Degeneration Revealed by Bioinformatics Methods.

answer: @entity6


abstract: Experiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl @entity0 (DR). The @entity0 were fed a low @entity6 (0.1% @entity5 ) or high @entity6 (8% @entity5 ) diet for 8 weeks. Blood pressure in DS fed a high @entity6 diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. @entity3 , @entity7 , and @entity9 induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high @entity6 diet. The relaxations in response to @entity8 were only slightly, but significantly, depressed in DS fed a high @entity6 diet. Removal of the endothelium greatly enhanced the response to @entity2 and @entity4 . In rings with, but not without, endothelium taken from @entity0 fed a high @entity6 diet, the tension developed in response to @entity2 and @entity4 was significantly greater than that in animals fed a low @entity6 diet. These experiments indicate that endothelium-dependent relaxations to @entity3 , @entity7 , and @entity9 are depressed in @entity1 Dahl @entity0 ; this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high @entity6 diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function.

title: Endothelium-dependent vascular responses in normotensive and XXXX Dahl @entity0 .

answer: @entity1


abstract: Experiments were designed to study endothelium-dependent responses in salt-sensitive (DS) and salt-resistant Dahl @entity0 (DR). The @entity0 were fed a low @entity6 (0.1% @entity5 ) or high @entity6 (8% @entity5 ) diet for 8 weeks. Blood pressure in DS fed a high @entity6 diet was higher than that in the remaining animals. Aortic rings with and without endothelium were suspended for isometric tension recording. @entity3 , @entity7 , and @entity9 induced endothelium-dependent relaxations that were significantly depressed in the aorta of DS fed a high @entity6 diet. The relaxations in response to @entity8 were only slightly, but significantly, depressed in DS fed a high @entity6 diet. Removal of the endothelium greatly enhanced the response to @entity2 and @entity4 . In rings with, but not without, endothelium taken from @entity0 fed a high @entity6 diet, the tension developed in response to @entity2 and @entity4 was significantly greater than that in animals fed a low @entity6 diet. These experiments indicate that endothelium-dependent relaxations to @entity3 , @entity7 , and @entity9 are depressed in @entity1 Dahl @entity0 ; this effect probably reflects a decreased release of endothelium-derived relaxing factor(s), although structural changes might contribute; and the responsiveness to vasoconstrictor agents is increased in DS and DR fed a high @entity6 diet. These findings may indicate differential effects of blood pressure and dietary salt on endothelial function.

title: Endothelium-dependent vascular responses in normotensive and @entity1 Dahl XXXX .

answer: @entity0


abstract: INTRODUCTION: We examined potential prothrombotic and proinflammatory effects of @entity6 in 16 otherwise healthy @entity7 subjects and 16 matched controls. METHODS: Markers of fibrinolysis, @entity1 generation and @entity0 were assessed in plasma before, during and 1h after a 3h intravenous infusion of @entity6 . In addition, placebo experiments with saline infusion were carried out. RESULTS: Baseline plasminogen activator inhibitor type-1 activity and plasmin-antiplasmin-complex concentrations were similar in @entity3 and controls, as were @entity2 , leukocyte counts and @entity4 . @entity5 levels were higher in @entity3 , and we observed a greater @entity1 generating potential in @entity3 (calibrated automated thrombogram), but no signs of elevated @entity1 generation in vivo (prothrombin fragment 1+2). During angiotensin infusion plasminogen activator inhibitor type-1 activity decreased and plasmin-antiplasmin-complex concentrations increased similarly in @entity3 and controls. Total and maximal amount of @entity1 generated was unchanged, as were prothrombin-fragment-1+2 levels. @entity2 and leukocyte counts increased similarly in both groups during @entity8 infusion, while @entity5 tended to increase in @entity3 and increased in controls. During saline infusion plasminogen activator inhibitor type-1 activity and prothrombin fragment 1+2 concentrations fell, whereas other markers were unchanged. CONCLUSIONS: @entity3 exhibits an increased @entity1 generation potential, an intact fibrinolysis, and has no convincing signs of @entity0 . Angiotensin has proinflammatory effects, and might have minor profibrinolytic and procoagulatory effects.

title: Haemostatic and inflammatory alterations in @entity7 , and the impact of XXXX infusion.

answer: @entity6


abstract: INTRODUCTION: We examined potential prothrombotic and proinflammatory effects of @entity6 in 16 otherwise healthy @entity7 subjects and 16 matched controls. METHODS: Markers of fibrinolysis, @entity1 generation and @entity0 were assessed in plasma before, during and 1h after a 3h intravenous infusion of @entity6 . In addition, placebo experiments with saline infusion were carried out. RESULTS: Baseline plasminogen activator inhibitor type-1 activity and plasmin-antiplasmin-complex concentrations were similar in @entity3 and controls, as were @entity2 , leukocyte counts and @entity4 . @entity5 levels were higher in @entity3 , and we observed a greater @entity1 generating potential in @entity3 (calibrated automated thrombogram), but no signs of elevated @entity1 generation in vivo (prothrombin fragment 1+2). During angiotensin infusion plasminogen activator inhibitor type-1 activity decreased and plasmin-antiplasmin-complex concentrations increased similarly in @entity3 and controls. Total and maximal amount of @entity1 generated was unchanged, as were prothrombin-fragment-1+2 levels. @entity2 and leukocyte counts increased similarly in both groups during @entity8 infusion, while @entity5 tended to increase in @entity3 and increased in controls. During saline infusion plasminogen activator inhibitor type-1 activity and prothrombin fragment 1+2 concentrations fell, whereas other markers were unchanged. CONCLUSIONS: @entity3 exhibits an increased @entity1 generation potential, an intact fibrinolysis, and has no convincing signs of @entity0 . Angiotensin has proinflammatory effects, and might have minor profibrinolytic and procoagulatory effects.

title: Haemostatic and inflammatory alterations in XXXX , and the impact of @entity6 infusion.

answer: @entity7


abstract: BACKGROUND: Therapists frequently advise activity pacing as a coping strategy to manage long-term conditions (for example, @entity6 , chronic @entity2 and @entity7 / @entity7 ). However, 'activity pacing' has not been clearly operationalised and there is a paucity of empirical evidence regarding pacing. This may be partly due to the absence of a widely-used pacing scale. We previously developed a 38-item Activity Pacing Questionnaire (APQ-38) using a Delphi technique. OBJECTIVE: Explore the psychometric properties of the APQ-38: identify underlying pacing themes, and assess the reliability and validity of the scale. DESIGN: Cross-sectional questionnaire study. METHODS: Three hundred and eleven adult @entity0 with @entity4 and/or @entity5 participated, of whom 69 completed the test-retest analysis. Data were analysed using exploratory factor analysis, internal and test-retest reliability, and validity against two existing pacing subscales and validated measures of @entity2 , @entity5 , @entity1 , @entity3 , avoidance, and mental and physical function. RESULTS: Following factor analysis, twelve items were removed and five themes of pacing were identified in the resulting APQ-26: Activity adjustment, Activity consistency, Activity progression, Activity planning and Activity acceptance. These demonstrated satisfactory internal consistency (Cronbach's a=0.72-0.92), test-retest reliability (ICC=0.50-0.78, p <=0.001) and construct validity. Activity adjustment, Activity progression and Activity acceptance correlated with worsened symptoms; Activity consistency correlated with improved symptoms; and Activity planning correlated with both improved and worsened symptoms. LIMITATIONS: Data were collected from self-report questionnaires only. CONCLUSIONS: Developed to be widely used across a heterogeneous group of @entity0 with @entity4 and/or @entity5 , the APQ-26 is multifaceted and demonstrates reliability and validity. Further study will explore the effects of pacing on @entity0 ' symptoms to guide therapists towards advising pacing themes with empirical benefits.

title: Assessing the Psychometric Properties of an Activity Pacing Questionnaire for Chronic XXXX and Fatigue.

answer: @entity2


abstract: UNASSIGNED: In voxel-based morphometry studies of @entity2 , the relation between causal theories of @entity2 and @entity0 (WM) volume alterations is still under debate. Some alterations are consistently reported, but others failed to reach significance. We investigated @entity0 alterations in a large sample of Dutch students (37 dyslexics and 57 @entity1 ) with two analyses: group differences in local @entity0 and total @entity0 and WM volume and correlations between @entity0 and WM volumes and five behavioural measures. We found no significant group differences after corrections for multiple comparisons although total WM volume was lower in the group of dyslexics when age was partialled out. We presented an overview of uncorrected clusters of voxels (p   <   0.05, cluster size k   >   200) with reduced or increased @entity0 volume. We found four significant correlations between factors of @entity2 representing various behavioural measures and the clusters found in the first analysis. In the whole sample, a factor related to performances in spelling correlated negatively with @entity0 volume in the left posterior cerebellum. Within the group of dyslexics, a factor related to performances in Dutch-English rhyme words correlated positively with @entity0 volume in the left and right caudate nucleus and negatively with increased total WM volume. Most of our findings were in accordance with previous reports. A relatively new finding was the involvement of the caudate nucleus. We confirmed the multiple cognitive nature of @entity2 and suggested that experience greatly influences anatomical alterations depending on various subtypes of @entity2 , especially in a student sample.

title: @entity2 and voxel-based morphometry: correlations between five behavioural measures of XXXX and gray and white matter volumes.

answer: @entity2


abstract: UNASSIGNED: In voxel-based morphometry studies of @entity2 , the relation between causal theories of @entity2 and @entity0 (WM) volume alterations is still under debate. Some alterations are consistently reported, but others failed to reach significance. We investigated @entity0 alterations in a large sample of Dutch students (37 dyslexics and 57 @entity1 ) with two analyses: group differences in local @entity0 and total @entity0 and WM volume and correlations between @entity0 and WM volumes and five behavioural measures. We found no significant group differences after corrections for multiple comparisons although total WM volume was lower in the group of dyslexics when age was partialled out. We presented an overview of uncorrected clusters of voxels (p   <   0.05, cluster size k   >   200) with reduced or increased @entity0 volume. We found four significant correlations between factors of @entity2 representing various behavioural measures and the clusters found in the first analysis. In the whole sample, a factor related to performances in spelling correlated negatively with @entity0 volume in the left posterior cerebellum. Within the group of dyslexics, a factor related to performances in Dutch-English rhyme words correlated positively with @entity0 volume in the left and right caudate nucleus and negatively with increased total WM volume. Most of our findings were in accordance with previous reports. A relatively new finding was the involvement of the caudate nucleus. We confirmed the multiple cognitive nature of @entity2 and suggested that experience greatly influences anatomical alterations depending on various subtypes of @entity2 , especially in a student sample.

title: XXXX and voxel-based morphometry: correlations between five behavioural measures of @entity2 and gray and white matter volumes.

answer: @entity2


abstract: INTRODUCTION: Diagnosis of @entity3 ( @entity3 ) remains uncertain when nerve conduction studies (NCS) fail to show @entity2 . METHODS: We conducted a retrospective study of @entity0 who presented with clinical criteria of @entity3 in whom electrodiagnostic (EDX) criteria of definite or probable @entity3 were missing [axonal sensory-motor @entity1 (n=23), normal EDX with pure sensory presentation (n=3)]. All @entity0 received immunomodulatory treatment. Twenty-six @entity0 were evaluated with somatosensory evoked potentials (SSEPs), MRI of spinal roots, CSF analysis, and/or nerve biopsy. Diagnosis of @entity3 was considered to be confirmed in @entity0 who responded to immunotherapy. RESULTS: 22 of 26 @entity0 (85%) had SSEPs reflecting abnormal proximal conduction in sensory fibers, including 14 who had only clinical and SSEP data in favor of @entity3 . SSEPs were abnormal in 16 of 20 responders (80%) to immunotherapy. CONCLUSION: SSEP recording contributes to diagnosis of @entity3 when NCS fail to detect @entity4 . This article is protected by copyright. All rights reserved.

title: Diagnostic utility of somatosensory evoked potentials in chronic polyradiculopathy without electrodiagnostic signs of XXXX .

answer: @entity4


abstract: PET/CT with the @entity4 analog @entity5 has several potential applications for monitoring @entity1 response to therapy in @entity0 with @entity6 ( @entity6 ). A prerequisite for many of these applications is detailed knowledge of the repeatability of quantitative parameters derived from @entity7 -FDG PET/CT studies. METHODS: The repeatability of the @entity7 -FDG signal was evaluated in 2 prospective multicenter trials. @entity0 with advanced @entity6 ( @entity1 stage III-IV) underwent two @entity5 PET/CT studies while not receiving therapy. @entity1 @entity5 uptake was quantified by measurement of the maximum standardized uptake value within a lesion (SUVmax) and the average SUV within a small volume of interest around the site of maximum uptake (SUVpeak). Analysis was performed for the lesion in the chest with the highest @entity5 uptake and a size of at least 2 cm ( @entity2 ) as well as for up to 6 additional lesions per @entity0 . Repeatability was assessed by Bland-Altman plots and calculation of 95% repeatability coefficients (RCs) of the log-transformed SUV differences. RESULTS: Test-retest repeatability was assessed in 74 @entity0 (34 from the ACRIN 6678 trial and 40 from the Merck MK-0646-008 trial). SUVpeak was 11.57    7.89 g/mL for the ACRIN trial and 6.89    3.02 for the Merck trial. The lower and upper RCs were -28% (95% confidence interval [CI], -35% to -23%) and +39% (95% CI, 31% to 54%) in the ACRIN trial, indicating that a decrease of SUVpeak by more than 28% or an increase by more than 39% has a probability of less than 2.5%. The corresponding RCs from the Merck trial were -35% (95% CI, -42% to -29%) and +53% (95% CI, 41% to 72%). Repeatability was similar for SUVmax of the @entity2 , averaged SUVmax, and averaged SUVpeak of up to 6 lesions per @entity0 . CONCLUSION: The variability of repeated measurements of @entity1 @entity5 uptake in @entity0 with @entity6 is somewhat larger than previously reported in smaller single-center studies but comparable to that of @entity3 in a previous multicenter trial. The variability of measurements supports the definitions of @entity1 response according to PET Response Criteria in @entity1 .

title: Repeatability of @entity5 PET/CT in Advanced XXXX : Prospective Assessment in 2 Multicenter Trials.

answer: @entity6


abstract: PET/CT with the @entity4 analog @entity5 has several potential applications for monitoring @entity1 response to therapy in @entity0 with @entity6 ( @entity6 ). A prerequisite for many of these applications is detailed knowledge of the repeatability of quantitative parameters derived from @entity7 -FDG PET/CT studies. METHODS: The repeatability of the @entity7 -FDG signal was evaluated in 2 prospective multicenter trials. @entity0 with advanced @entity6 ( @entity1 stage III-IV) underwent two @entity5 PET/CT studies while not receiving therapy. @entity1 @entity5 uptake was quantified by measurement of the maximum standardized uptake value within a lesion (SUVmax) and the average SUV within a small volume of interest around the site of maximum uptake (SUVpeak). Analysis was performed for the lesion in the chest with the highest @entity5 uptake and a size of at least 2 cm ( @entity2 ) as well as for up to 6 additional lesions per @entity0 . Repeatability was assessed by Bland-Altman plots and calculation of 95% repeatability coefficients (RCs) of the log-transformed SUV differences. RESULTS: Test-retest repeatability was assessed in 74 @entity0 (34 from the ACRIN 6678 trial and 40 from the Merck MK-0646-008 trial). SUVpeak was 11.57    7.89 g/mL for the ACRIN trial and 6.89    3.02 for the Merck trial. The lower and upper RCs were -28% (95% confidence interval [CI], -35% to -23%) and +39% (95% CI, 31% to 54%) in the ACRIN trial, indicating that a decrease of SUVpeak by more than 28% or an increase by more than 39% has a probability of less than 2.5%. The corresponding RCs from the Merck trial were -35% (95% CI, -42% to -29%) and +53% (95% CI, 41% to 72%). Repeatability was similar for SUVmax of the @entity2 , averaged SUVmax, and averaged SUVpeak of up to 6 lesions per @entity0 . CONCLUSION: The variability of repeated measurements of @entity1 @entity5 uptake in @entity0 with @entity6 is somewhat larger than previously reported in smaller single-center studies but comparable to that of @entity3 in a previous multicenter trial. The variability of measurements supports the definitions of @entity1 response according to PET Response Criteria in @entity1 .

title: Repeatability of XXXX PET/CT in Advanced @entity6 : Prospective Assessment in 2 Multicenter Trials.

answer: @entity5


abstract: BACKGROUND: Enrolling @entity0 in studies of @entity4 ( @entity4 ) is challenging because of the high fatality of the disease. We hypothesized that a prospective clinic-based study with rapid ascertainment would result in high participation rates. Using that strategy, we established the @entity3 Study (qpcs) to investigate the genetics and causes of @entity4 and other @entity1 ( @entity1 ) that are also rare and underrepresented in research studies. METHODS: @entity0 diagnosed with @entity4 or pat were introduced to the study at their initial clinical encounter, with a strategy to enrol @entity0 within 2 weeks of diagnosis. @entity0 self-referrals and referrals of unaffected individuals with an increased risk of @entity4 were also accepted. Family histories, epidemiologic and clinical data, and biospecimens were collected. Additional relatives were enrolled in families at increased genetic risk. RESULTS: The first 346 completed referrals led to 306 probands being enrolled, including 190 probands affected with @entity4 , who represent the population focus of the qpcs. Participation rates were 88.4% for all referrals and 89.2% for @entity4 referrals. Family history, epidemiologic and clinical data, and biospecimens were ascertained from 91.9%, 54.6%, and 97.5% respectively of @entity0 with @entity4 . Although demographics and trends in risk factors in our @entity0 were consistent with published statistics for @entity0 with @entity4 , the qpcs is enriched for families with French-Canadian ancestry (37.4%), a population with recurrent germ-line mutations in @entity2 . CONCLUSIONS: Using rapid ascertainment, a @entity4 and pat research registry with high participation rates can be established. The qpcs is a valuable research resource and its enrichment with @entity0 of French-Canadian ancestry provides a unique opportunity for studies of heredity in these diseases.

title: Establishing a clinic-based XXXX research registry in Quebec.

answer: @entity3


abstract: UNASSIGNED: @entity1 @entity0 have been shown to exhibit subnormal levels of electrophysiological suppression to self-initiated, button press elicited sounds. These self-suppression deficits have been shown to improve following the imposition of a subsecond delay between the button press and the evoked sound. The current study aimed to investigate whether nonclinical individuals who scored highly on the personality dimension of schizotypy would exhibit similar patterns of self-suppression abnormalities to those exhibited in @entity1 . Thirty-nine nonclinical individuals scoring above the median (High Schizotypy) and 41 individuals scoring below the median (Low Schizotypy) on the Schizotypal Personality Questionnaire (SPQ) underwent electroencephalographic recording. The amplitude of the N1-component was calculated while @entity0 (1) listened to tones initiated by a willed button press and played back with varying delay periods between the button press and the tone (Active conditions) and (2) passively listened to a series of tones (Listen condition). N1-suppression was calculated by subtracting the amplitude of the N1-component of the auditory evoked potential in the Active condition from that of the Listen condition, while controlling for the activity evoked by the button press per se. The Low Schizotypy group exhibited significantly higher levels of N1-suppression to undelayed tones compared to the High Schizotypy group. Furthermore, while N1-suppression was found to decrease linearly with increasing delays between the button press and the tone in the Low Schizotypy group, this was not the case in the High Schizotypy group. The findings of this study suggest that nonclinical, highly schizotypal individuals exhibit subnormal levels of N1-suppression to undelayed self-initiated tones and an abnormal pattern of N1-suppression to delayed self-initiated tones. To the extent that these results are similar to those previously reported in @entity0 with @entity1 , these findings provide support for the existence of a neurophysiological "continuum of @entity2 ".

title: Cortical Suppression to Delayed Self-Initiated Auditory Stimuli in Schizotypy: Neurophysiological Evidence for a Continuum of XXXX .

answer: @entity2


abstract: BACKGROUND: @entity4 is implicated in different @entity3 . The mechanisms underlying this invalidating @entity3 are not yet understood. Therefore, the present study investigated if unilateral or bilateral lesions of the medial forebrain bundle (MFB) could induce a trigeminal @entity5 ( @entity5 ) comparable to that obtained after chronic construction @entity2 (CCI-IoN) in @entity1 . METHODS: Unilateral and bilateral nigrostriatal lesions were obtained by injecting @entity7 into the MFB, and peripheral lesion was obtained by CCI-IoN. Static allodynia behaviour was tested by a mild non-noxious static von Frey filament stimulus. The analgesic effects of @entity6 (D2R agonist) were assessed by both intraperitoneal and intracisternal injections. Finally, immunohistochemical study was done to investigate the implication of the protein kinase c isoform gamma (PKCy) and the phosphorylated form of extracellular signal-related kinase 1/2 (pERK1/2) in @entity3 sensitization at segmental level. RESULTS: @entity7 -lesioned animals developed @entity5 in the orofacial region as assessed by non-noxious stimuli. Intraperitoneal and intracisternal injections of @entity6 alleviated this allodynic behaviour. Investigations within the medullary dorsal horn revealed an increase in PKCy expression, a protein implicated in the chronicity of @entity3 , within superficial laminae in @entity7 -lesioned @entity1 . Also static mechanical stimulations of the orofacial region evoked increased expression of the molecular @entity3 marker pERK1/2 in @entity7 -lesioned @entity1 . CONCLUSION: Our data show that unilateral and bilateral @entity4 depletion promoted trigeminal @entity5 comparable to that obtained after CCI-IoN. This allodynia can be alleviated by D2R activation, making D2R agonist a potential analgesic for orofacial @entity0 .

title: Nigrostriatal dopaminergic depletion produces orofacial XXXX .

answer: @entity5


abstract: UNASSIGNED: In this review we aimed to update the possibilities of @entity6 treatment in @entity0 excluding those with a desire for pregnancy. @entity6 is defined as the presence of endometrial tissue within the myometrium and frequently underestimated. Over the last decades, its pathophysiology has been better known. The diagnosis is essentially based on clinical symptoms like @entity2 and @entity5 . Transvaginal ultrasound and magnetic resonance imaging are the main tools of the radiologic diagnosis. However, the definitive diagnosis is histological. The most effective treatment remains hysterectomy; however it is expensive, radical and at risk of morbidity compared with medical or surgical conservative management. The literature has reported several series of @entity0 undergoing various treatments, thus allowing different therapeutic options. The @entity7 -releasing intrauterine device showed its efficacy alone or in combination with hysteroscopic treatment. Oral @entity8 , @entity3 agonists are useful at short term or in @entity1 . Some conservative treatments like focused ultrasound therapies or uterus-sparing operative treatment stay under evaluation and seems to be effective. Embolization has been the subject of several studies and must be outlined. Furthermore, several molecules, such as modulators of @entity4 receptors and the aromatase inhibitors have been recently studied and are perhaps future treatments.

title: [Treatment of XXXX (excluding pregnancy project)].

answer: @entity6


abstract: UNASSIGNED: Endocrine-mediated effects in fish populations have been widely documented. Most attention has been focused on feminization caused by estrogenic substances, but this paper reviews evidence for the effects of a group of fungicides and pharmaceuticals, the @entity2 , which have been reported to cause masculinization in fish. The paper considers information from laboratory studies on the effects of @entity1 compounds on fish endocrinology, and on the potential existence of such effects in wild fish. The occurrence of some @entity2 in effluents and surface waters has also been briefly reviewed. Under laboratory conditions, many @entity2 are able to cause masculinization or defeminization in fish by inhibition of the P450 enzyme aromatase ( @entity0 ). However, in no case where such effects have been observed in the field has a link been established with this group of substances. In most instances, other more convincing explanations have been proposed. Peak concentrations of some @entity2 in surface waters can approach those which, under continuous long-term exposure in the laboratory, might lead to some aromatase inhibition. However, available data on exposure and effects provide reassurance that the concentrations of @entity2 found in surface waters are too low to cause adverse effects in fish by interference with their endocrine system. Compared to the widespread observations of feminization and estrogenic effects in (male) fish, there are relatively few papers describing masculinization or defeminization in (female) wild fish populations, suggesting that this is quite a rare phenomenon. The significance of this result is emphasized by the fact that fish are among the best studied organisms in the environment.

title: A review of the effects of XXXX compounds in fish and their possible involvement in masculinization of wild fish populations.

answer: @entity1


abstract: OBJECTIVE: To determine frequency of HLA-DR alleles in Pakistani @entity0 of @entity4 in comparison with local healthy controls. STUDY DESIGN: Cross-sectional, comparative study. PLACE AND DURATION OF STUDY: Department of Immunology, @entity2 ( @entity2 ), Rawalpindi, from January 2011 to January 2014. METHODOLOGY: Twenty eight @entity0 with biopsy proven diagnosis of @entity4 referred from Department of Dermatology, Military Hospital, Rawalpindi were included. @entity0 were compared with a group of 150 unrelated local healthy subjects. DNA was extracted from peripheral blood collected in Tri- @entity1 . @entity3 typing was carried out on allele level ( @entity3 *01 - @entity3 *16) using SSP (sequence specific primers). HLA type was determined by agarose gel electrophoresis and results recorded. Phenotype frequency of various alleles among @entity0 group and control group was calculated by direct counting and significance of their association was determined by Fisher's exact test/ Chi square test. RESULTS: A total of 12 male and 16 female @entity0 , with age ranging from 21 to 34 (mean 23.4 years) were genotyped for @entity3 loci. A statistically significant association of the disease with @entity3 *04 was observed (50% versus 20.7% in controls, p < 0.05). CONCLUSION: There is a strong association of @entity3 *04 with @entity4 in Pakistani population.

title: HLA- DR Alleles in Pakistani @entity0 of XXXX .

answer: @entity4


abstract: OBJECTIVE: To determine frequency of HLA-DR alleles in Pakistani @entity0 of @entity4 in comparison with local healthy controls. STUDY DESIGN: Cross-sectional, comparative study. PLACE AND DURATION OF STUDY: Department of Immunology, @entity2 ( @entity2 ), Rawalpindi, from January 2011 to January 2014. METHODOLOGY: Twenty eight @entity0 with biopsy proven diagnosis of @entity4 referred from Department of Dermatology, Military Hospital, Rawalpindi were included. @entity0 were compared with a group of 150 unrelated local healthy subjects. DNA was extracted from peripheral blood collected in Tri- @entity1 . @entity3 typing was carried out on allele level ( @entity3 *01 - @entity3 *16) using SSP (sequence specific primers). HLA type was determined by agarose gel electrophoresis and results recorded. Phenotype frequency of various alleles among @entity0 group and control group was calculated by direct counting and significance of their association was determined by Fisher's exact test/ Chi square test. RESULTS: A total of 12 male and 16 female @entity0 , with age ranging from 21 to 34 (mean 23.4 years) were genotyped for @entity3 loci. A statistically significant association of the disease with @entity3 *04 was observed (50% versus 20.7% in controls, p < 0.05). CONCLUSION: There is a strong association of @entity3 *04 with @entity4 in Pakistani population.

title: HLA- DR Alleles in Pakistani XXXX of @entity4 .

answer: @entity0


abstract: BACKGROUND AND PURPOSE: @entity1 is generally treated with anticoagulation. However, some @entity0 do not respond to medical therapy and these might benefit from mechanical thrombectomy. The aim of this study was to gain a better understanding of the efficacy and safety of mechanical thrombectomy in @entity0 with @entity1 , by performing a systematic review of the literature. METHODS: We identified studies published between January 1995 and February 2014 from PubMed and Ovid. We included all cases of @entity1 in whom mechanical thrombectomy was performed with or without intrasinus thrombolysis. Good outcome was defined as normal or mild @entity2 at discharge (modified Rankin Scale, 0-2). Secondary outcome variables included periprocedural complications and recanalization rates. RESULTS: Our study included 42 studies (185 @entity0 ). Sixty percent of @entity0 had a pretreatment @entity3 and 47% were stuporous or comatose. AngioJet was the most commonly used device (40%). Intrasinus thrombolysis was used in 131 @entity0 (71%). Overall, 156 (84%) @entity0 had a good outcome and 22 (12%) died. Nine (5%) @entity0 had no recanalization, 38 (21%) had partial, and 137 (74%) had near to complete recanalization. The major periprocedural complication was new or increased @entity3 (10%). The use of AngioJet was associated with lower rate of complete recanalization (odds ratio, 0.2; 95% confidence interval, 0.09-0.4) and lower chance of good outcome (odds ratio, 0.5; 95% confidence interval, 0.2-1.0). CONCLUSIONS: Our systematic review suggests that mechanical thrombectomy is reasonably safe but controlled studies are required to provide a definitive answer on its efficacy and safety in @entity0 with @entity1 .

title: Mechanical Thrombectomy in XXXX : Systematic Review of 185 Cases.

answer: @entity1


abstract: @entity1 has been one of the most extensively debated and continues to evolve in search for the ideal technique. Even though the method to diagnose @entity2 has largely remained clinical, recently other modalities have detected @entity2 that are not picked up on clinical examination or are incorrectly labeled. Laparoscopy, for the first time has given surgeons the unique opportunity to look at both sides of the groin and to detect and study the contra lateral groin in a @entity0 of clinically unilateral @entity2 . This has given rise to some interesting findings. In the pediatric age group the value of bilateral detection and repair has been extensively debated. However, the same is not true for the adults despite the facts that there are better methods for detection, better understanding of pathogenesis of @entity2 and better repair techniques that can take care of bilateral repair without adding to morbidity.That @entity2 is not a simple derivative of patent processus vaginalis or strain related cause is beginning to be better understood now. It may primarily be a disorder of collagen metabolism with genetic basis. Laparoscopy has also made us wiser in detection of type of @entity2 and examination of both groin areas. In several studies there have been a high percentage of undetected @entity2 or additional defects. This was never realized earlier as in open surgery there is no question of exploring the asymptomatic groin. Laparoscopy in bilateral repair is safe and does not add significantly to the operating time, cost or morbidity.At our Department of Minimal Access Surgery, Sir Ganga Ram Hospital, New Delhi, India we have been performing Endoscopic Totally Extraperitoneal (TEP) repair for all simple and complicated @entity1 since 1994. We now routinely perform a bilateral repair based on our understanding that the pathogenesis of @entity2 is a complex process and any genetic basis of @entity3 has to affect the @entity0 bilaterally. The clinical examination may have unacceptably low sensitivity. Early identification and repair obviates the need for reoperation, reduces overall costs and eliminates further anaesthetic and operative risks for the @entity0 .

title: Totally extraperitoneal repair of XXXX : A case for bilateral repair.

answer: @entity1