abstract: @entity10 ( @entity10 ) is an immune complex-mediated reaction that may complicate the course of @entity6 . @entity9 in @entity7 , though reported, are exceedingly rare. We report the case of a 32 year old female @entity0 who presented initially at our OPD with @entity10 . Cutaneous examination revealed @entity5 over dorsum of right foot and thickened right lateral popliteal nerve. Slit skin smear (SSS) from ear lobes revealed AFB with a bacteriological index of 2+. She was started on MDT, tablet @entity4 200 mg twice a day, and 30 mg oral @entity3 . Two months later, she presented with generalised @entity1 , large target lesions over the back, and @entity2 over lower extremities and annular pattern of bullae, over both arms. A SSS was repeated which was positive for AFB. Histopathology from @entity9 was consistent with @entity10 . Direct Immunofluorescence (DIF) study was negative. Our @entity0 improved rapidly after she was started on @entity8 100 mg twice daily, with withdrawal of @entity4 . @entity11 ( @entity11 ) and annular @entity9 have been reported in @entity0 on treatment with @entity4 . This case is being presented due to the unusual and varied manifestation of @entity7 in a 34 year old female @entity0 .

title: Annular @entity9 with atypical XXXX in leprosy.

answer: @entity11


abstract: @entity10 ( @entity10 ) is an immune complex-mediated reaction that may complicate the course of @entity6 . @entity9 in @entity7 , though reported, are exceedingly rare. We report the case of a 32 year old female @entity0 who presented initially at our OPD with @entity10 . Cutaneous examination revealed @entity5 over dorsum of right foot and thickened right lateral popliteal nerve. Slit skin smear (SSS) from ear lobes revealed AFB with a bacteriological index of 2+. She was started on MDT, tablet @entity4 200 mg twice a day, and 30 mg oral @entity3 . Two months later, she presented with generalised @entity1 , large target lesions over the back, and @entity2 over lower extremities and annular pattern of bullae, over both arms. A SSS was repeated which was positive for AFB. Histopathology from @entity9 was consistent with @entity10 . Direct Immunofluorescence (DIF) study was negative. Our @entity0 improved rapidly after she was started on @entity8 100 mg twice daily, with withdrawal of @entity4 . @entity11 ( @entity11 ) and annular @entity9 have been reported in @entity0 on treatment with @entity4 . This case is being presented due to the unusual and varied manifestation of @entity7 in a 34 year old female @entity0 .

title: Annular XXXX with atypical @entity11 in leprosy.

answer: @entity9


abstract: Cell surface pellicular membranes (PM) were isolated from promastigote forms of @entity4 by differential and discontinuous @entity0 gradient centrifugation procedures. The PM had a density equivalent of approximately 1.19 g/cm3. As ascertained by electron microscopy, longitudinal parallel arrays of subpellicular microtubules (MT) remained attached to the isolated PM inner lamina, and this feature was used to assess membrane fraction purity. Gradient fractions having greater than or equal to 95% of all membranes combined with MT were obtained routinely. The attached MT imparted a structural asymmetry to the PM permitting uniequivocal identification of the membrane external and cytoplasmic surfaces. The supramolecular structure of attached MT was evident in negatively stained PM. In ultrathin sections, PM had a mean width of approximately 7.2 nm and attached MT a diameter of approximately 29 nm. The MT were apparently cross-bridged both to each other and to the PM via a flocculent filamentoid nexus. As determined by @entity3 - @entity2 gel electrophoresis, isolated PM contained approximately 40 peptide bands ranging in apparent molecular weight from less than or equal 1.2 x 10(4) to greater than or equal to 2.2 x 10(5) daltons. Of these, 19 were stained with @entity5 -Schiffs' reagent suggesting that most PM @entity1 constituents were present as glycopeptides. A presumpative glycolipid!polysaccharide PM constituent was also identified in such gels.

title: Isolation and partial characterization of surface membranes from XXXX promastigotes.

answer: @entity4


abstract: The aim is to present a case of @entity3 in the periocular area in a 10-year-old female through retrospective review of medical records of a single @entity0 . A 10-year-old female developed a lesion under her right eyebrow over a period of one year. The rest of the ophthalmic history was unremarkable. On examination, oval, well-defined, subcutaneous @entity1 measuring 7 x 4 mm was found under the right eyebrow. It gave bluish tint under the firmly adherent overlying skin of normal color and texture. Rocky hard and non-tender, it was mobile over the underlying tissues. Total excision biopsy was performed under general anesthesia. Histopathologic analysis confirmed the diagnosis ofpilomatrixoma. @entity3 is a rare @entity1 with head, neck and periocular area being the commonest sites. It is often clinically misdiagnosed and/or missed on differential diagnosis. Although a @entity1 , malignant transformation into @entity2 has been described. Thus, total surgical excision of the mass is recommended.

title: Periocular XXXX : case report.

answer: @entity3


abstract: OBJECTIVE: To investigate the effect of triptolide (TPL) on the renal tissue of @entity0 @entity2 and its possible mechanisms. METHODS: SD @entity2 were randomly divided into the normal control group (as the normal group), the @entity0 model group (the model group), the low dose TPL treatment group (the low dose TPL group, TPL 0.2 mg/kg by gastrogavage), the high dose TPL treatment group (the high dose TPL group, TPL 0.4 mg/kg by gastrogavage). Equal volume of normal saline was given to @entity2 in the normal group and the model group. Five @entity2 were randomly selected from each group at week 4, 8, and 12 of the experiment to detect body weight, kidney weight, 24 h urinary albumin (24 h UAL), plasma glucose (FBG), total cholesterol (TC), total triglyeride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), white blood cell (WBC), and hemoglobin A1c (HbA1c). The mRNA and protein expression of @entity3 ( @entity3 ) in the renal tissue was assessed by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA). The renal tissue was pathologically stained by HE, PAS, and Masson staining. The glomerular and renal tubular interstitial lesions were observed at each time point. The @entity1 index (GSI) was observed by PAS staining, and the @entity1 ( @entity1 ) was calcutated. RESULTS: Compared with the same group at week 4, the expression of 24 h UAL, @entity3 , GSI, and @entity1 at week 12 significantly decreased in two TPL groups (P <0.01). Compared with the same group at week 8, the expression of 24 h UAL, @entity3 , GSI, and @entity1 at week 12 also significantly decreased in the two TPL groups (P <0. 05, P <0.01). Compared with the normal group, body weight and the kidney weight obviously decreased at week 4, 8, and 12 in the model group (P <0. 01); 24 h UAL, FBG, TG, TC, HbA1c, @entity3 , GSI, and @entity1 were obviously elevated (P <0.01). Compared with the model group, 24 h UAL, @entity3 , GSI, and @entity1 also decreased in the two TPL treatment groups (P <0.01). Compared with the low dose TPL group, they were attenuated in the high dose TPL group (P <0. 05, P <0. 01). CONCLUSION: TPL could not only inhibit the over-expression of @entity3 , but also improve the @entity1 and @entity1 in the renal tissue of @entity0 @entity2 .

title: [Effect of triptolide on the expression of XXXX in the renal tissue of diabetic nephropathy @entity2 ].

answer: @entity3


abstract: OBJECTIVE: To investigate the effect of triptolide (TPL) on the renal tissue of @entity0 @entity2 and its possible mechanisms. METHODS: SD @entity2 were randomly divided into the normal control group (as the normal group), the @entity0 model group (the model group), the low dose TPL treatment group (the low dose TPL group, TPL 0.2 mg/kg by gastrogavage), the high dose TPL treatment group (the high dose TPL group, TPL 0.4 mg/kg by gastrogavage). Equal volume of normal saline was given to @entity2 in the normal group and the model group. Five @entity2 were randomly selected from each group at week 4, 8, and 12 of the experiment to detect body weight, kidney weight, 24 h urinary albumin (24 h UAL), plasma glucose (FBG), total cholesterol (TC), total triglyeride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), white blood cell (WBC), and hemoglobin A1c (HbA1c). The mRNA and protein expression of @entity3 ( @entity3 ) in the renal tissue was assessed by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA). The renal tissue was pathologically stained by HE, PAS, and Masson staining. The glomerular and renal tubular interstitial lesions were observed at each time point. The @entity1 index (GSI) was observed by PAS staining, and the @entity1 ( @entity1 ) was calcutated. RESULTS: Compared with the same group at week 4, the expression of 24 h UAL, @entity3 , GSI, and @entity1 at week 12 significantly decreased in two TPL groups (P <0.01). Compared with the same group at week 8, the expression of 24 h UAL, @entity3 , GSI, and @entity1 at week 12 also significantly decreased in the two TPL groups (P <0. 05, P <0.01). Compared with the normal group, body weight and the kidney weight obviously decreased at week 4, 8, and 12 in the model group (P <0. 01); 24 h UAL, FBG, TG, TC, HbA1c, @entity3 , GSI, and @entity1 were obviously elevated (P <0.01). Compared with the model group, 24 h UAL, @entity3 , GSI, and @entity1 also decreased in the two TPL treatment groups (P <0.01). Compared with the low dose TPL group, they were attenuated in the high dose TPL group (P <0. 05, P <0. 01). CONCLUSION: TPL could not only inhibit the over-expression of @entity3 , but also improve the @entity1 and @entity1 in the renal tissue of @entity0 @entity2 .

title: [Effect of triptolide on the expression of @entity3 in the renal tissue of diabetic nephropathy XXXX ].

answer: @entity2


abstract: BACKGROUND: Many minimally invasive interventional techniques as well as expectant treatment exist for the management of lower ureteric calculi. This study was conducted to evaluate th efficacy of @entity2 as an expulsive pharmacologic therapy for the treatment of distal uretern stone. METHODS: This randomized control trial included 100 @entity0 over 18 years of age wit stone Size > or = mm in distal 1/3 of ureter. @entity0 were randomly assigned into two groups (A _ B Group A @entity0 were given Capsule @entity2 0.4 mg, 1 daily up to 4 weeks while group B @entity0 were given placebo, 1 Capsule daily up to 4 weeks. The primary endpoint was expulsio rate. A written informed consent was taken from all the @entity0 . Expulsion time, need for analgesics, need for hospitalization and @entity1 were secondary endpoints. RESULTS: A total of 49 @entity0 in group A and 48 @entity0 in group B reported back, therefore 97 out of 10 @entity0 were evaluated. Mean age of the @entity0 was 36.34 years (range 18-57 years). Mea stone size was 5.78 mm (range 4-8 mm) in greatest dimension. A stone expulsion rate of 85.71C (42 @entity0 ) was noted in group A and 54.20% (26 @entity0 ) in group B. Group A revealed statistically significant advantage in term of stone expulsion rate (p=0.032). Considering expulsio time in days group A showed statistically significant advantage (p=0.015). Regarding age, se) stone size and stone lateralization (right/left), there was no significant difference between th group A and B. No @entity1 were noted in both the groups. CONCLUSION: By usin @entity2 a higher stone expulsion rates can be achieved in a shorter time. More randomize control trials are required to establish @entity2 as a standard medical expulsive treatment fc

title: MEDICAL EXPULSIVE TREATMENT OF DISTAL URETERAL STONE USING XXXX .

answer: @entity2


abstract: BACKGROUND: Migraine affects more than 10% of the Hungarian population, causes significant disability and severely affects @entity0 ' generic and condition-specific quality of life. Despite these facts, a significant proportion of @entity0 is not diagnosed and not treated adequately. @entity1 centres can provide care for only a fraction of all @entity0 . The task of primary care providers would be greatly simplified by a reliable self-administered @entity2 screening questionnaire. OBJECTIVE: To develop a short and reliable questionnaire as a @entity2 screening tool. METHODS: Outpatients at the @entity1 Service, Department of Neurology, Semmelweis University completed a self-administered questionnaire which contained 9 yes/no questions about their headaches' characteristics. The number of 'yes' answers (the @entity0 ' total score) was evaluated in connection with the diagnosis based on the International @entity1 Society criteria. We calculated the sensitivity, specificity, positive and negative predictive value as well as the misclassification rate for each total score value and used these to establish the final cutoff value of the questionnaire. 306 @entity0 (242 females, mean age 39.1    13.3 years) were enrolled. The diagnosis was @entity2 in 244. RESULTS: Completing the questionnaire did not pose any difficulty for the @entity0 . At a cutoff value of 5 points the questionnaire's sensitivity was 0.96 and specificity was 0.61. The positive predictive value was 0.91 and the negative pre- dictive value was 0.81. The misclassification rate was 0.11. DISCUSSION: Our results show that the questionnaire may help the diagnosis of @entity2 . In order to use it in medical practice, its further evaluation is necessary on a large representative sample of the Hungarian population.

title: [Examining the diagnostic accuracy of a new XXXX screener].

answer: @entity2


abstract: @entity3 with an acutely angled parent artery are difficult to access for coiling. This study aimed to investigate the safety and effectiveness of microcatheter looping for embolization of @entity2 with access difficulty. Ten @entity0 (male:female=5:5) with @entity2 treated with the microcatheter looping technique were analyzed retrospectively. The parent artery formed an acute angle with the major artery in five @entity3 . The microcatheter was looped into a "a" loop for treatment in the anterior temporal artery @entity3 and a "U" loop in the remaining nine @entity3 . All ten @entity3 were successfully treated with the microcatheter looping technique. The microcatheter tip was successfully navigated into the @entity3 sac and remained stable throughout the embolization process. All @entity3 were occluded with @entity1 in five and near- @entity1 in five, and the parent artery remained patent in all cases. No complications occurred peri-procedurally. The Glasgow Outcome Scale was 5 in all @entity0 before discharge. Follow-up angiography six to 12 months later revealed a good occlusion status of the @entity3 . The microcatheter looping technique is effective when the conventional embolization technique fails to treat @entity2 with difficult access especially when the parent artery forming an acute angle with the major artery exacerbates difficult access to the @entity3 .

title: Microcatheter looping facilitates access to both the acutely angled parent artery and XXXX for effective embolization.

answer: @entity2


abstract: Identification of @entity0 with acute @entity1 who could most benefit from arterial recanalization after endovascular treatment remains an unsettled issue. Although several classifications of collateral circulation have been proposed, the clinical role of collaterals is still debated. We evaluated the effect of the collateral circulation in relation to recanalization as a predictor of clinical outcome. Data were prospectively collected from 103 @entity0 consecutively treated for proximal @entity4 . The collateral circulation was evaluated with a novel semiquantitative-qualitative score, the Careggi collateral score (CCS), in six grades. Both CCS and recanalization grades (TICI) were analysed in relation to clinical outcome. A statistical analysis was performed to evaluate the effect of interaction between recanalization and collateral circulation on clinical outcome. Out of the 103 @entity0 , 37 (36.3%) had poor collaterals, and 65 (63.7%) had good collaterals. @entity0 with good collaterals had lower basal National Institute of Health @entity1 Scale (NIHSS), more @entity3 , smaller lesions at 24h CT scan and better functional outcome. After multivariate analysis, the interaction between recanalization and collateral grades was significantly stronger as a predictor of good outcome (OR 6.87, 95% CI 2.11-22.31) or @entity2 (OR 4.66, 95%CI 1.48-14.73) compared to the effect of the single variables. Collaterals showed an effect of interaction with the recanalization grade in determining a favourable clinical outcome. Assessment of the collateral circulation might help predict clinical results after recanalization in @entity0 undergoing endovascular treatment for acute @entity1 .

title: Effect of the Interaction between Recanalization and Collateral Circulation on Functional Outcome in Acute XXXX .

answer: @entity1


abstract: The advent of flow dynamics and the recent availability of perfusion analysis software have provided new diagnostic tools and management possibilities for cerebrovascular @entity0 . To this end, we provide an example of the use of color-coded angiography and its application in a rare case of a @entity0 with a pure @entity7 . A 42-year-old male chronic smoker was evaluated in the emergency room due to sudden onset of severe @entity1 , @entity2 , @entity3 and left-sided weakness. Head computed tomography revealed a right @entity9 . Cerebral digital subtraction angiography (DSA) showed a right middle cerebral @entity6 consisting of convoluted and ectatic collateral vessels supplying the distal middle cerebral artery territory-M1 proximally occluded. An associated medial lenticulostriate artery @entity5 was found. Brain single-photon emission computed tomography with and without @entity8 failed to show problems in vascular reserve that would indicate the need for flow augmentation. Twelve months after discharge, the @entity0 recovered from the left-sided weakness and did not present any similar events. A follow-up DSA and perfusion study using color-coded perfusion analysis showed perforator @entity5 resolution and adequate, albeit delayed perfusion in the involved vascular territory. We propose a combined congenital and acquired mechanism involving @entity4 with secondary dysplastic changes in collateral supply to the distal MCA territory. Angiographic and cerebral perfusion work-up was used to exclude the need for flow augmentation. Nevertheless, the natural course of this lesion remains unclear and long-term follow-up is warranted.

title: Color-coded digital subtraction angiography in the management of a rare case of middle cerebral artery pure XXXX . A technical and case report.

answer: @entity6


abstract: BACKGROUND: The objective of our study was to assess the cost-effectiveness of ivabradine plus standard care (SoC) in @entity1 ( @entity1 ) @entity0 with sinus rhythm and a baseline heart rate   >=    75 b.p.m. in Greece, in comparison with current SoC alone. METHODS: An existing cost-effectiveness model consisting of two health states, was adapted to the Greek health care setting. All clinical inputs of the model (i.e. mortality rates, hospitalization rates, NYHA class distribution and utility values) were estimated from SHIFT trial data. All costing data used in the model reflects the year 2013 (in    ). An incremental cost effectiveness ratio (ICER) per quality-adjusted life year (QALY) gained was calculated. Deterministic and probabilistic sensitivity analyses (PSA) were conducted. The horizon of analysis was over @entity0 life time and both cost and outcomes were discounted at 3.5% per year. The analysis was conducted from a Greek third party-payer perspective. RESULTS: The Markov analysis revealed that the discounted quality-adjusted survival was 4.27 and 3.99 QALYs in the ivabradine plus SoC and SoC alone treatment arms, respectively. The cumulative lifetime total cost per @entity0 was    8,665 and    5,873, for ivabradine plus SoC and SoC alone, respectively. The ICER for ivabradine plus SoC versus SoC alone was estimated as    9,986 per QALY gained. The PSA showed that the likelihood of ivabradine plus SoC being cost-effective at a threshold of    36,000/QALY was found to be 95%. CONCLUSIONS: Ivabradine plus SoC may be regarded as a  cost-effective option for the treatment in @entity1 @entity0 in Greece.

title: Economic evaluation of ivabradine in the treatment of XXXX in Greece.

answer: @entity1


abstract: OBJECTIVE: The management of @entity0 with supra-tentorial @entity3 ( @entity3 ) remains controversial. Here we critically evaluate the safety, feasibility, and outcomes following decompressive hemicraniectomy (HC) with or without clot evacuation in the management of @entity0 with large ICHs. METHODS: We analyzed data from 73 consecutive @entity0 managed with a HC for a spontaneous @entity3 . All relevant @entity0 variables at initial presentation and management were compiled. Variables were modeled as independent regressors against the three-month Glasgow Outcome Score using a multivariate logistic regression model. RESULTS: Over 7 years, HC was performed in 73 @entity0 with clot evacuation in 86% and HC alone in 14%. The average @entity3 volume was 81cc and the median HC surface area was 105cm(2). 26 @entity0 were @entity1 at initial presentation. Three-month functional outcomes were favorable in 29%, unfavorable in 44% and 27% of @entity0 expired. Admission Glasgow @entity1 Scale (p=0.003), dominant hemisphere @entity3 location (p=0.01) and @entity2 volume (p=0.002) contributed significantly to the outcome, as estimated by a multivariate analysis. Eight surgical complications occurred. CONCLUSIONS: Early HC with or without clot evacuation is feasible and safe for managing spontaneous @entity3 . Our experience in this uncontrolled retrospective series, the largest such series in the modern era, suggests that it may be of particular benefit in @entity0 with large non-dominant hemisphere @entity3 who are not moribund at presentation. Our findings suggest that a prospective randomized trial of HC vs. craniotomy for @entity3 be conducted.

title: Decompressive hemicraniectomy with or without clot evacuation for large spontaneous supratentorial XXXX .

answer: @entity3


abstract: OBJECTIVES: @entity3 ( @entity3 ) are a challenging condition in vascular neurosurgery. Disease natural history and its management is still debated. In the present paper we report our center series on @entity3 over a period of 10 years. Our data were compared with relevant literature. @entity0 AND METHODS: Our series includes 45 cases: 14 cavernous sinus, 11 transverse-sigmoid, 8 @entity0 tentorial, 6 anterior cranial fossa, 5 @entity0 spinal, 1 @entity0 foramen magnum. RESULTS AND CONCLUSIONS: DVAFs distribution, clinical presentation and hemorrhagic risk are discussed. Cavernous sinus @entity3 are the most common site in our series. Other locations in order of frequency are transverse-sigmoid sinus, tentorial, anterior cranial fossa, spinal and foramen magnum. The majority of @entity0 presented with non-aggressive symptoms. 18% presented with @entity2 : all the @entity1 occurred in high-grade @entity3 . For most @entity0 , endovascular treatment, transarterial or transvenous, was the first option. Surgery was performed for the anterior cranial fossa @entity3 and other complex lesions draining mostly transverse-sigmoid sinus and tentorium. In 7% of cases a combination of endovascular+surgical treatment was used. Our series has been carefully analyzed in comparison 'side by side' with most relevant literature on DVAFs, focusing particularly on management strategies, therapeutic options and risks related to treatment.

title: Diagnosis and management of XXXX : A 10 years single-center experience.

answer: @entity3


abstract: UNASSIGNED: @entity1 ( @entity1 ) diets in pregnancy and lactation impair offspring brain development and modify offspring behavior. We hypothesized multigenerational passage of altered behavioral outcomes as has been demonstrated following other developmental programming challenges. We investigated potential multigenerational effects of @entity1 in @entity0 pregnancy and/or lactation on offspring risk assessment behavior. Founder generation mothers (F0) ate 20% casein (C) or restricted (R) 10% casein diet, providing four groups: CC, RR, CR, and RC (first letter pregnancy, second letter lactation diet) to evaluate offspring (F1) effects influenced by @entity1 in F0. On postnatal day (PND 250), F1 males were mated to non-colony siblings producing F2. On PND 90, F2 females (in diestrous) and F2 males were tested in the elevated plus maze (EPM) and open field. Corticosterone was measured at PND 110. Female but not male CR and RC F2 made more entries and spent more time in EPM open arms than CC females. Overall activity was unchanged as observed in male F1 fathers. There were no open field differences in F2 of either sex, indicating that multigenerational @entity1 effects are due to altered risk assessment, not locomotion. @entity1 in pregnancy reduced F1 male and F2 female corticosterone. We conclude that @entity1 in pregnancy and/or lactation increases the innate tendency to explore novel environments in F2 females via the paternal linage, suggesting lower levels of caution and/or higher impulsiveness to explore unknown spaces. Further studies will be necessary to identify the epigenetic modifications in the germ line through the paternal linage.

title: Paternal line multigenerational passage of altered risk assessment behavior in female but not male XXXX offspring of mothers fed a low protein diet.

answer: @entity0


abstract: INTRODUCTION: Reports on the content of aspirated coronary thrombi have until now mainly focused on cellular components. We investigated the genetic expression of selected mediators and proteases actively involved in the pathophysiological process of @entity7 in aspirated coronary thrombi. MATERIALS AND METHODS: In this cross-sectional study, RNA from coronary thrombi in 67 subjects with @entity7 was isolated. Gene expression arrays of selected markers were performed by RT-PCR with relative quantification. RESULTS: Twenty of 22 markers were expressed in>50% of the samples. The relative quantification of @entity15 correlated negatively to total ischemic time (p=0.01), while genes related to fibrinolysis ( @entity14 , @entity11 , @entity10 ), @entity2 ( @entity17 , @entity6 , @entity12 , @entity16 , @entity5 ) and plaque instability ( @entity9 and @entity13 ) correlated positively to total ischemic time (all<0.05). Long ischemic time (>4.0hours) associated with a relative reduction in the expression of @entity15 and a relative increase in the expression of @entity14 , @entity11 , @entity10 , @entity17 , @entity6 , @entity12 , @entity16 , @entity5 , @entity9 and @entity13 . The presence of @entity4 2 @entity1 associated with 3.2-fold increased @entity10 expression (adjusted p=0.033), while the presence of @entity3 associated with about 50% reduction of @entity8 and @entity13 . Smoking and overweight did not affect any markers. CONCLUSIONS: The gene expression profile from coronary thrombi differed according to ischemic time, shown by reduced content of platelet markers and increased content of fibrinolytic, inflammatory and plaque instability mediators over time. @entity0 with @entity4 2 @entity1 showed increased expression of @entity10 , indicative of reduced fibrinolysis.

title: Genes expressed in coronary thrombi are associated with ischemic time in @entity0 with XXXX .

answer: @entity7


abstract: INTRODUCTION: Reports on the content of aspirated coronary thrombi have until now mainly focused on cellular components. We investigated the genetic expression of selected mediators and proteases actively involved in the pathophysiological process of @entity7 in aspirated coronary thrombi. MATERIALS AND METHODS: In this cross-sectional study, RNA from coronary thrombi in 67 subjects with @entity7 was isolated. Gene expression arrays of selected markers were performed by RT-PCR with relative quantification. RESULTS: Twenty of 22 markers were expressed in>50% of the samples. The relative quantification of @entity15 correlated negatively to total ischemic time (p=0.01), while genes related to fibrinolysis ( @entity14 , @entity11 , @entity10 ), @entity2 ( @entity17 , @entity6 , @entity12 , @entity16 , @entity5 ) and plaque instability ( @entity9 and @entity13 ) correlated positively to total ischemic time (all<0.05). Long ischemic time (>4.0hours) associated with a relative reduction in the expression of @entity15 and a relative increase in the expression of @entity14 , @entity11 , @entity10 , @entity17 , @entity6 , @entity12 , @entity16 , @entity5 , @entity9 and @entity13 . The presence of @entity4 2 @entity1 associated with 3.2-fold increased @entity10 expression (adjusted p=0.033), while the presence of @entity3 associated with about 50% reduction of @entity8 and @entity13 . Smoking and overweight did not affect any markers. CONCLUSIONS: The gene expression profile from coronary thrombi differed according to ischemic time, shown by reduced content of platelet markers and increased content of fibrinolytic, inflammatory and plaque instability mediators over time. @entity0 with @entity4 2 @entity1 showed increased expression of @entity10 , indicative of reduced fibrinolysis.

title: Genes expressed in coronary thrombi are associated with ischemic time in XXXX with @entity7 .

answer: @entity0


abstract: @entity3 is a chronic @entity1 inherited in an autosomal dominant fashion, and characterized as @entity5 . @entity8 has been used to produce an animal model of @entity3 . In the present study, the effect of treadmill exercise on @entity7 and motor coordination focusing on the apoptosis in the hippocampus was investigated using @entity8 -induced @entity3 @entity0 . @entity3 was induced by unilateral intrastriatal injection of @entity8 (2  L of 100 nmol) using stereotaxic instrument. The @entity0 in the treadmill exercise groups were subjected to run on a treadmill for 30 min once a day during 14 days. Spatial learning ability and motor coordination were determined by radial 8-arm maze test and rota-rod test. Immunohistochemistry for @entity6 and western blot for @entity4 and @entity2 were also conducted for the detection of apoptosis. In the present results, spatial learning ability and motor coordination were deteriorated by intrastriatal injection of @entity8 . In contrast, treadmill exercise exerted ameliorating effect on @entity8 -induced deterioration of spatial learning ability and motor coordination. @entity2 expression in the hippocampus was de-creased and expressions of casepase-3 and @entity4 in the hippocampus were increased in the @entity8 -induced @entity3 @entity0 . Treadmill exercise increased @entity2 expression and decreased expressions of casepase-3 and @entity4 in the @entity3 @entity0 . The present results showed that treadmill exercise might ameliorate @entity8 -induced loss of spatial learning ability and motor coordination by suppressing apoptosis in the hippocampus.

title: Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in XXXX @entity0 .

answer: @entity3


abstract: @entity3 is a chronic @entity1 inherited in an autosomal dominant fashion, and characterized as @entity5 . @entity8 has been used to produce an animal model of @entity3 . In the present study, the effect of treadmill exercise on @entity7 and motor coordination focusing on the apoptosis in the hippocampus was investigated using @entity8 -induced @entity3 @entity0 . @entity3 was induced by unilateral intrastriatal injection of @entity8 (2  L of 100 nmol) using stereotaxic instrument. The @entity0 in the treadmill exercise groups were subjected to run on a treadmill for 30 min once a day during 14 days. Spatial learning ability and motor coordination were determined by radial 8-arm maze test and rota-rod test. Immunohistochemistry for @entity6 and western blot for @entity4 and @entity2 were also conducted for the detection of apoptosis. In the present results, spatial learning ability and motor coordination were deteriorated by intrastriatal injection of @entity8 . In contrast, treadmill exercise exerted ameliorating effect on @entity8 -induced deterioration of spatial learning ability and motor coordination. @entity2 expression in the hippocampus was de-creased and expressions of casepase-3 and @entity4 in the hippocampus were increased in the @entity8 -induced @entity3 @entity0 . Treadmill exercise increased @entity2 expression and decreased expressions of casepase-3 and @entity4 in the @entity3 @entity0 . The present results showed that treadmill exercise might ameliorate @entity8 -induced loss of spatial learning ability and motor coordination by suppressing apoptosis in the hippocampus.

title: Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in @entity3 XXXX .

answer: @entity0


abstract: BACKGROUND AND STUDY AIMS: During @entity2 (ESD), the feature of a muscle layer being pulled toward a @entity1 is sometimes detected. We call this feature the muscle-retracting sign (MR sign). The aim of this study was to evaluate whether the MR sign is associated with particular types of @entity3 and whether it has any clinical significance for ESD sessions. @entity0 AND METHODS: A total of 329 @entity0 underwent ESD for 357 @entity2 . The frequency of positivity for the MR sign was evaluated in different morphologic and histopathologic types of @entity1 . The success rate of complete resection and the incidence of complications were also evaluated according to whether lesions were positive or negative for the MR sign. RESULTS: The rates of positivity for the MR sign in the various lesion types were as follows: laterally spreading tumor-granular nodular mixed type (LST-G-M), 9.6%; laterally spreading tumor-granular homogeneous type (LST-G-H) and laterally spreading tumor-nongranular type (LST-NG), 0%; sessile type, 41.2%. The resection rate was 100% (329/329) in lesions negative for the MR sign; however, it was 64.3% (18/28) in lesions positive for the MR sign, which was significantly lower (P<0.001). CONCLUSIONS: The MR sign was present only in some protruding lesions, and more importantly, it was associated with a high risk of @entity1 removal by ESD. Our data indicate that lesions positive for the MR sign lesions should be dissected with great caution; alternatively, based on the features of the individual case, a switch to surgery should be considered for the benefit of the @entity0 .

title: Clinical significance of the muscle-retracting sign during XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity6 infects the @entity0 eye leading to @entity5 . Extracellular proteins, the earliest proteins that come in contact with the host and virulence related exoproteins, were identified in the fungus isolated from infected @entity1 . Virulence of the corneal isolates was tested in the Galleria mellonella larvae model and those isolates showing higher virulence were taken for subsequent exoproteome analysis. High resolution two-dimensional electrophoresis and mass spectrometry were used to generate A. flavus exoproteome reference map as well as to profile most of the exoproteins. Analysis of the identified proteins clearly shows the major biological processes that they are involved in. Nearly 50% of the exoproteins possess catalytic activity and one of these, an alkaline @entity4 protease (Alp1) is present in high abundance as well as multiple proteoforms. Many proteins in the A. flavus exoproteome have been shown to be virulence factors in other pathogens indicating the probable role for these proteins in the @entity2 as well. Interestingly, the majority of the exoproteins do not have secretory signal indicating that they are secreted through the non-classical pathway. Thus, this study provides a clue to the early strategies employed by the pathogen to establish an @entity2 in an immunocompetent host. BIOLOGICAL SIGNIFICANCE: The outcome of a @entity3 in an immunocompetent @entity0 eye depends on the ability of the fungus to overcome the host defense and propagate itself. In this process, the earliest events with respect to the fungal proteins involved include the secretory proteins of the invading organism. As a first step towards understanding the role of the extracellular proteins, exoproteome profile of the fungal isolates was generated. The fungal isolates from @entity1 showed a distinct pattern of the exoproteome when compared to the saprophyte. Since corneal isolates also showed higher virulence in the insect larval model, presumably the proteins elaborated by the corneal isolates are virulence related. One of the abundant proteins is an alkaline @entity4 protease and this protein exists as multiple proteoforms. This study reports the comprehensive profile of exoproteome and reveals proteins that are potential virulence factors.

title: Exoproteome of XXXX corneal isolates and saprophytes: Identification of proteoforms of an oversecreted alkaline protease.

answer: @entity6


abstract: INTRODUCTION: @entity3 in @entity6 ( @entity6 ) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the @entity3 . Peripheral and central sensitization have been suggested as two of the underlying mechanisms that contribute to @entity3 in @entity6 . The aim of this study was to explore in symptomatic knee @entity6 @entity0 , the structural changes assessed by magnetic resonance imaging (MRI) that could be used as markers of @entity1 ( @entity1 ). METHODS: This cross-sectional observational pilot study included 50 knee @entity6 @entity0 with moderate to severe @entity3 (VAS >= 40) in the target knee. The presence of @entity1 was determined based on the PainDETECT questionnaire. Among the 50 @entity0 included, 25 had PainDETECT score  <=12 (unlikely @entity1 ), 9 had PainDETECT score between 13 and 18 (uncertain @entity1 ) and 16 had PainDETECT score >= 19 (likely @entity1 ). WOMAC, PainDETECT, and @entity3 scores as well as knee MRI were assessed. RESULTS: Data showed no significant difference in demographic characteristics between the three groups. However, a positive and statistically significant association was found between the WOMAC @entity3 (P <0.001), function (P <0.001), @entity5 as well as higher @entity3 score (P   =   0.023), and PainDETECT scores. Although no difference was found in the cartilage volume between groups, the presence of meniscal extrusion in both medial (P   =   0.006) and lateral (P   =   0.023) compartments, and presence of @entity7 in the lateral compartment (P   =   0.011), were significantly associated with increasing PainDETECT score. Moreover, the presence of @entity4 in the lateral plateau and the extent of the synovial membrane thickness in the lateral recess were associated with increasing PainDETECT scores (P   =   0.032, P   =   0.027, respectively). CONCLUSIONS: In this study, @entity2 , particularly extrusion, were found to be among the strongest risk factors for @entity1 in knee @entity6 @entity0 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01733277. Registered 16 November 2012.

title: The presence of @entity2 is a strong predictor of XXXX in symptomatic knee osteoarthritis: a cross-sectional pilot study.

answer: @entity1


abstract: INTRODUCTION: @entity3 in @entity6 ( @entity6 ) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the @entity3 . Peripheral and central sensitization have been suggested as two of the underlying mechanisms that contribute to @entity3 in @entity6 . The aim of this study was to explore in symptomatic knee @entity6 @entity0 , the structural changes assessed by magnetic resonance imaging (MRI) that could be used as markers of @entity1 ( @entity1 ). METHODS: This cross-sectional observational pilot study included 50 knee @entity6 @entity0 with moderate to severe @entity3 (VAS >= 40) in the target knee. The presence of @entity1 was determined based on the PainDETECT questionnaire. Among the 50 @entity0 included, 25 had PainDETECT score  <=12 (unlikely @entity1 ), 9 had PainDETECT score between 13 and 18 (uncertain @entity1 ) and 16 had PainDETECT score >= 19 (likely @entity1 ). WOMAC, PainDETECT, and @entity3 scores as well as knee MRI were assessed. RESULTS: Data showed no significant difference in demographic characteristics between the three groups. However, a positive and statistically significant association was found between the WOMAC @entity3 (P <0.001), function (P <0.001), @entity5 as well as higher @entity3 score (P   =   0.023), and PainDETECT scores. Although no difference was found in the cartilage volume between groups, the presence of meniscal extrusion in both medial (P   =   0.006) and lateral (P   =   0.023) compartments, and presence of @entity7 in the lateral compartment (P   =   0.011), were significantly associated with increasing PainDETECT score. Moreover, the presence of @entity4 in the lateral plateau and the extent of the synovial membrane thickness in the lateral recess were associated with increasing PainDETECT scores (P   =   0.032, P   =   0.027, respectively). CONCLUSIONS: In this study, @entity2 , particularly extrusion, were found to be among the strongest risk factors for @entity1 in knee @entity6 @entity0 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01733277. Registered 16 November 2012.

title: The presence of XXXX is a strong predictor of @entity1 in symptomatic knee osteoarthritis: a cross-sectional pilot study.

answer: @entity2


abstract: AIM: There is an urgent need for effective geriatric interventions to meet the health service demands of the growing older population. In this paper, we systematically review and update existing literature on interventions within @entity2 ( @entity2 ) targeted towards reducing @entity2 re-visits, hospitalizations, nursing home admissions and @entity1 in older @entity0 after initial @entity2 discharge. METHODS: Databases Medline, CINAHL, Embase and Web of Science were searched to identify all articles published up to June 2012 that focused on older adults in the @entity2 , included a comparison group, and reported quantitative results in four primary outcomes: @entity2 re-visits, hospitalizations, nursing home admissions and @entity1 after initial @entity2 discharge. RESULTS: Of the 2826 titles screened, just nine studies met our inclusion criteria. The studies varied in their design and outcome measurements such that results could not be combined. Two trends surfaced: (i) more intensive interventions more frequently resulted in reduced adverse outcomes than did simple referral intervention types; and (ii) among the lowest intensity, referral-based interventions, studies that used a validated prediction tool to identify high-risk @entity0 more frequently reported improved outcomes than those that did not use such a tool. CONCLUSION: Of the few studies that met the inclusion criteria, there was a lack of consistency and clarity in study designs and evaluative outcomes. Despite this, more intensive interventions that followed @entity0 beyond a referral and the use of a clinical risk prediction tool appeared to be associated with improved outcomes. The dearth of rigorous evaluations with standardized methodologies precludes further recommendations. Geriatr Gerontol Int 2015;       :       -      .

title: Efficacy of emergency department-based interventions designed to reduce repeat visits and other adverse outcomes for older XXXX after discharge: A systematic review.

answer: @entity0


abstract: BACKGROUND AND AIM: The aim of this study was to assess the cosmetic results and the impact on the breast development of a right anterolateral thoracotomy (RALT) in pre-pubertal @entity0 who underwent RALT for correction of @entity1 . METHODS: From December 2002 to July 2010, 25 female @entity0 with a mean age of 8.5        1.3 years underwent repair of @entity1 with a right anterolateral thoracotomy. Breast symmetry was described by a clinical index. The degree of @entity2 was measured by clinical examination. The subjective evaluation in breast asymetry, size, and shape was assessed by a survey obtained by the @entity0 . RESULTS: There was no intraoperative or postoperative complication or late mortality in the thoracotomy approach or in the long-term follow-up (7.5        2.2 years). According to the survey, breast asymmetry and differences between both breast size or shape were found in 15 (60%) and seven (28%) @entity0 , respectively. One @entity0 (4%) complained of a @entity3 . Mild sensitive skin deficit in the mammary area was determined in four @entity0 (16%). According to the objective assessment, breast asymmetry was found 12 @entity0 (48%) with index 1 and 13 @entity0 (52%) with index 2. CONCLUSION: Although it is safe, the RALT is associated with the potential to effect unilateral breast development.

title: Right Anterolateral Thoracotomy in the Repair of XXXX : Effect on Breast Development.

answer: @entity1


abstract: AIM: To analyze the profile, etiology, complications, medical and surgical management, and visual outcome among pediatric @entity3 @entity0 seen at a referral @entity3 clinic in India. DESIGN: Retrospective cohort study, tertiary hospital setting. METHODS: Records between January 2007 and April 2010 were reviewed for @entity0 with @entity3 who were 0-18 years of age. @entity3 diagnosis was based on SUN criteria; complications, medical and surgical management, and visual outcome were evaluated. RESULTS: Among 190 @entity0 with @entity3 , 64.2% were @entity0 and 112 had unilateral disease. The median age at presentation was 11 years. Ninety-nine (52%) had anterior, 49 (26%) intermediate, 27 (14%) posterior, and 15 (7.9%) @entity5 . @entity3 was present in 44 @entity0 , of which 21 cases (48%) were @entity6 . Parasitic, @entity3 was encountered. A total of 174 @entity0 were followed over 315.5 @entity0 -years (median   =   1.35 years). Seventy-seven (40.5%) @entity0 had complications related to @entity3 . Forty-six out of 77 complications noted were complicated @entity2 . Surgical procedures were done in 46.9% (15%/100 @entity0 -years). The visual acuity improved by two Snellen lines in the uveitic eyes, following therapy in 120 @entity0 , was stable in 40 @entity0 , and worsened in 14 @entity0 . Follow-up visual acuity was missing for 16 @entity0 . CONCLUSION: A large proportion of pediatric @entity3 cases experienced complications of @entity3 , mostly prior to presentation for subspecialty management. These often required surgical management, most commonly to clear the @entity1 of @entity2 for @entity1 and to prevent @entity4 . In most cases, tertiary management was associated with visual improvement. The results suggest that subspecialty management can result in improvement of the clinical course of pediatric @entity3 .

title: Pattern of XXXX Seen at a Tertiary Referral Center from India.

answer: @entity3


abstract: 35--40% of @entity4 among @entity2 @entity0 present as abdominal troubles. These are difficult to interpret in the case of larvate @entity2 which manifests itself mainly in the somatic sphere. For the last twenty years, we have noticed an @entity2 . As a result, @entity0 are often inadequately treated or submitted to surgery. This report is about a 37-year-old female @entity0 who was referred to us with the diagnosis of an acute abdomen. After extensive investigations we were able to rule out as well a mechanical as a reflectory ileus. Nevertheless, the rapid deterioration of her general condition, increasing peritonism and radiological evidence of ileus made us suspect a perforated @entity3 with accompanying @entity5 and perform an exploratory laparotomy 24 h later. We were very surprised not to discover any abnormal findings at operation. The consultant psychiatrist eventually diagnosed a @entity2 . Up to this date, we have not been able to discover any information about similar @entity0 presenting with such an acute history, even in specialised @entity1 literature. Should one refer such @entity0 with acute abdomen to the psychiatrist before operating?

title: [Laparotomy for acute XXXX ].

answer: @entity2


abstract: UNASSIGNED: @entity3 ( @entity3 ) are a group of primary @entity2 resulting from any one of a diverse group of mutations impacting T-cell development. @entity3 is diagnosed and classified through assessment of the lymphocyte subset(s) affected and by the mechanisms responsible for the primary @entity5 . Regardless of the genetics involved, @entity0 invariably succumb to an @entity1 without medical intervention. In the past, @entity0 were primarily identified either by previous family history, physical manifestations, or after the onset of symptoms. However, the introduction of newborn screening for @entity3 has allowed the pediatrician to identify these @entity0 at a much earlier age, greatly improving their survival. Currently, 23 states include @entity3 testing for @entity4 in their newborn screening platform. Protocols for confirmatory testing and medical intervention after a positive screen vary slightly from state-to-state. However, the standard curative treatment remains stem cell transplantation, although depending on the genetic cause of the disease, enzyme replacement and gene therapy may also be considered. [Pediatr Ann. 2015;44(7):e181-e187.].

title: Diagnostic Criteria and Evaluation of Severe XXXX in the Neonate.

answer: @entity2


abstract: UNASSIGNED: BackgroundProctitis after radiation therapy for @entity2 remains an ongoing clinical challenge and critical quality of life issue. SBRT could minimize @entity1 by reducing the volume of rectum receiving high radiation doses and offers the potential radiobiologic benefits of hypofractionation. This study sought to evaluate the incidence and severity of @entity4 following SBRT for @entity2 .MethodsBetween February 2008 and July 2011, 269 @entity0 with clinically localized @entity2 were treated definitively with SBRT monotherapy at Georgetown University Hospital. All @entity0 were treated to 35-36.25Gy in 5 fractions delivered with the CyberKnife Radiosurgical System (Accuray). @entity3 was recorded and scored using the CTCAE v.4. @entity5 were graded using the Vienna Rectoscopy Score (VRS). @entity4 was assessed via the Bowel domain of the Expanded Prostate Index Composite (EPIC)-26 at baseline and at 1, 3, 6, 9, 12, 18 and 24  months post-SBRT.ResultsThe median age was 69 years with a median prostate volume of 39 cc. The median follow-up was 3.9 years with a minimum follow-up of two years. The 2-year actuarial incidence of late rectal bleeding    grade 2 was 1.5%. Endoscopy revealed VRS Grade 2 @entity5 in 11% of @entity0 . All @entity4 symptoms increased at one month post-SBRT but returned to near-baseline with longer follow-up. The most bothersome symptoms were bowel urgency and frequency. At one month post-SBRT, 11.2% and 8.5% of @entity0 reported a moderate to big problem with bowel urgency and frequency, respectively. The EPIC bowel summary scores declined transiently at 1 month and experienced a second, more protracted decline between 6 months and 18 months before returning to near-baseline at two years post-SBRT. Prior to treatment, 4.1% of @entity0 felt their bowel function was a moderate to big problem which increased to 11.5% one month post-SBRT but returned to near-baseline at two years post-SBRT.ConclusionsIn this single institution cohort, the rate and severity of @entity4 observed following SBRT is low. QOL decreased on follow-up; however, our results compare favorably to those reported for @entity0 treated with alternative radiation modalities. Future prospective randomized studies are needed to confirm these observations.

title: @entity4 following stereotactic body radiation therapy for XXXX .

answer: @entity2


abstract: UNASSIGNED: BackgroundProctitis after radiation therapy for @entity2 remains an ongoing clinical challenge and critical quality of life issue. SBRT could minimize @entity1 by reducing the volume of rectum receiving high radiation doses and offers the potential radiobiologic benefits of hypofractionation. This study sought to evaluate the incidence and severity of @entity4 following SBRT for @entity2 .MethodsBetween February 2008 and July 2011, 269 @entity0 with clinically localized @entity2 were treated definitively with SBRT monotherapy at Georgetown University Hospital. All @entity0 were treated to 35-36.25Gy in 5 fractions delivered with the CyberKnife Radiosurgical System (Accuray). @entity3 was recorded and scored using the CTCAE v.4. @entity5 were graded using the Vienna Rectoscopy Score (VRS). @entity4 was assessed via the Bowel domain of the Expanded Prostate Index Composite (EPIC)-26 at baseline and at 1, 3, 6, 9, 12, 18 and 24  months post-SBRT.ResultsThe median age was 69 years with a median prostate volume of 39 cc. The median follow-up was 3.9 years with a minimum follow-up of two years. The 2-year actuarial incidence of late rectal bleeding    grade 2 was 1.5%. Endoscopy revealed VRS Grade 2 @entity5 in 11% of @entity0 . All @entity4 symptoms increased at one month post-SBRT but returned to near-baseline with longer follow-up. The most bothersome symptoms were bowel urgency and frequency. At one month post-SBRT, 11.2% and 8.5% of @entity0 reported a moderate to big problem with bowel urgency and frequency, respectively. The EPIC bowel summary scores declined transiently at 1 month and experienced a second, more protracted decline between 6 months and 18 months before returning to near-baseline at two years post-SBRT. Prior to treatment, 4.1% of @entity0 felt their bowel function was a moderate to big problem which increased to 11.5% one month post-SBRT but returned to near-baseline at two years post-SBRT.ConclusionsIn this single institution cohort, the rate and severity of @entity4 observed following SBRT is low. QOL decreased on follow-up; however, our results compare favorably to those reported for @entity0 treated with alternative radiation modalities. Future prospective randomized studies are needed to confirm these observations.

title: XXXX following stereotactic body radiation therapy for @entity2 .

answer: @entity4


abstract: OBJECTIVES: To determine what contribution prenatal ultrasound screening and neonatal pulse oximetry screening (POS) make to the timely diagnosis of @entity2 of the aorta (CoA). METHODS: We identified @entity0 and fetuses diagnosed with isolated CoA in our referral area between 2003 and 2012 who died without surgery, underwent surgical repair before 2 months of age, or were terminated after a prenatal diagnosis. Clinical data were collected from hospital charts. RESULTS: Only 3 of the 90 cases were diagnosed prenatally. Two of the 3 were born alive and in 1 case the couple opted for termination of pregnancy. Nineteen of the remaining 87 cases were born in units that used POS (hand and foot) and 4 of 19 screened positive. Of the remaining 83 cases, 46 were discharged undiagnosed (7 after nondiagnostic echocardiography), including 9 with a murmur and weak femoral pulses and 8 with a murmur and normal pulses. One was diagnosed postmortem after dying at home, and 22 of the remaining 45 discharged @entity0 were in circulatory failure on readmission. Five of the @entity0 who were not discharged died without surgery and undiagnosed CoA was the most probable cause of death in 2 of these @entity0 . CONCLUSIONS: The contribution of prenatal ultrasound screening and postnatal POS to the timely diagnosis of CoA was low. Careful physical examination of all newborns therefore continues to play a fundamental role in detecting this life-threatening @entity1 , and better screening methods need to be developed.

title: Late Diagnosis of XXXX Despite Prenatal Ultrasound and Postnatal Pulse Oximetry.

answer: @entity2


abstract: This paper presents the results of an experimental study of the biosynthesis of @entity1 nanoparticles (BMNPs) with particle sizes between 10nm and 60nm. The biocompatible magnetic nanoparticles are produced from @entity3 (M.M.) bacteria that respond to magnetic fields. M.M. bacteria were cultured and used to synthesize @entity1 nanoparticles. This was done in an enriched magnetic spirillum growth medium (EMSGM) at different pH levels. The nanoparticle concentrations were characterized with UV-Visible (UV-Vis) spectroscopy, while the particle shapes were elucidated via transmission electron microscopy (TEM). The structure of the particles was studied using X-ray diffraction (XRD), while the hydrodynamic radii, particle size distributions and polydispersity of the nanoparticles were characterized using dynamic light scattering (DLS). @entity2 reduction was also used to functionalize the BMNPs with a molecular recognition unit (luteinizing hormone releasing hormone, LHRH) that attaches specifically to receptors that are over-expressed on the surfaces of most @entity0 cell types. The resulting nanoparticles were examined using Fourier Transform Infrared (FTIR) spectroscopy and quantitative image analysis. The implications of the results are then discussed for the potential development of magnetic nanoparticles for the specific targeting and treatment of @entity0 .

title: Biosynthesis and the conjugation of XXXX nanoparticles with luteinizing hormone releasing hormone (LHRH).

answer: @entity1


abstract: BACKGROUND: Self-care, a key element of @entity2 care, is challenging for @entity0 with @entity1 . Mechanisms through which @entity1 affects self-care are not currently well defined but evidence from other @entity0 populations suggests that self-efficacy, or task-specific confidence, mediates the relationship between cognitive functioning and @entity0 behaviors such as self-care. OBJECTIVE: The aim of this study was to test the mediating role of self-care confidence in the relationship between cognition and self-care behaviors. DESIGN: A secondary analysis of data from a cross-sectional study. SETTING: Outpatient @entity2 clinics in 28 Italian provinces. @entity0 : 628 Italian @entity2 @entity0 . METHODS: We used the Self-Care of @entity2 Index v.6.2 to measure self-care maintenance, self-care management, and self-care confidence. Cognition was assessed with the Mini Mental State Examination. Structural equation modeling was used to analyze the data. RESULTS: @entity0 were 73 years old on average (SD=11), mostly (58%) male and mostly (77%) in New York Heart Association functional classes II and III. The mediation model showed excellent fit (comparative fit index=1.0; root mean square error of approximation=0.02): Self-care confidence totally mediated the relationship between cognition and self-care maintenance and management. CONCLUSION: Cognition affects self-care behaviors indirectly, through self-care confidence. Interventions aimed at improving self-care confidence may improve self-care, even in @entity2 @entity0 with @entity1 .

title: Self-care confidence may be the key: A cross-sectional study on the association between cognition and self-care behaviors in adults with XXXX .

answer: @entity2


abstract: OBJECTIVES: We conducted a randomized, controlled trial comparing the efficacy of an Integrated Risk Reduction Intervention (IRRI) to a control condition with the objective of improving mood stability and psychosocial functioning by reducing cardiometabolic risk factors in overweight/ @entity1 @entity0 with @entity3 . METHODS: A total of 122 @entity0 were recruited from our outpatient services and randomly allocated to IRRI (n  =  61) or @entity2 care with medical monitoring (n  =  61). Individuals allocated to IRRI received @entity2 treatment and assessment, medical monitoring by a nurse, and a healthy lifestyle program from a lifestyle coach. Those allocated to the control condition received @entity2 treatment and assessment and referral, if indicated, for medical problems. A mixed-effects model was used to examine the impact of the interventions on body mass index (BMI). Exploratory moderator analyses were used to characterize those individuals likely to benefit from each treatment approach. RESULTS: Analyses were conducted on data for the IRRI (n  =  58) and control (n  =  56) @entity0 with >= 1 study visit. IRRI was associated with a significantly greater rate of decrease in BMI (d  =  -0.51, 95% confidence interval: -0.91 to -0.14). Three variables ( @entity6 , total @entity4 , and instability of total sleep time) contributed to a combined moderator of faster decrease in BMI with IRRI treatment. CONCLUSIONS: Overweight/ @entity1 @entity0 with @entity3 can make modest improvements in BMI, even when taking medications with known potential for @entity5 . Our finding that a combination of three baseline variables provides a profile of @entity0 likely to benefit from IRRI will need to be tested further to evaluate its utility in clinical practice.

title: An Integrated Risk Reduction Intervention can reduce body mass index in individuals being treated for XXXX : results from a randomized trial.

answer: @entity3


abstract: Primary @entity8 (PIL) is a @entity3 , especially in adults. It causes a local disruption of chylus transport and is part of the exudative gastroenteropathies. Conservative therapy includes dietary measures or @entity5 medication. Taking the differential diagnosis of PIL into consideration is a major challenge, since @entity0 suffering from PIL may present with @entity2 and @entity7 or @entity6 . This can be explained by the chronic @entity1 leading to dilation of the vessels (intraluminal loss) and sometimes even to a @entity4 (peritoneal loss). Push-pull enteroscopy and capsule endoscopy are the proper interventional diagnostic tools to discover PIL. Exploratory laparoscopy may be useful in unclear cases. Surgical resection of the altered intestine has been described with positive results. Exploratory laparoscopy may even be a diagnostic tool in unclear cases. Resection of the altered intestine is a treatment option in symptomatic and treatment-refractory cases.

title: Surgical therapy of primary XXXX in adults.

answer: @entity8


abstract: UNASSIGNED: @entity3 ( @entity3 ) are the clinical consequence of spinal @entity2 and may be associated with @entity4 and aggravated @entity5 . However, the relative importance of @entity3 as an underlying cause of @entity5 and @entity4 is not known. The aim of this study was to investigate the relationship between prevalent @entity3 and the size of @entity4 in @entity7 @entity0 . Thirty-six @entity0 , aged 74.6        8.3 years, were consecutively recruited from the @entity2 unit at Uppsala University Hospital. The @entity0 had 1-9 radiographic verified @entity3 . @entity6 ( @entity6 ) and numeric rating scale were used to measure @entity5 and @entity1 . All @entity0 had a hyperkyphosis ( @entity6   >=    10   cm). Notably, there were no associations between numbers or location of @entity3 versus size of @entity5 (     =   0.15, p   =   0.4;      =   -0.27, p   =   0.12) or severity of @entity4 (     =   -0.08, p   =   0.66;      =   0.16, p   =   0.35). Furthermore, no association was evident between @entity5 and @entity4 (     =   -0.02, p   =   0.89). There was, however, an association between size of @entity5 and age (R   =   0.44, p   =   0.008). In conclusion, these data suggest that prevalent @entity3 are not significantly associated with @entity5 or @entity4 , in @entity0 with manifest spinal @entity2 .

title: Hyperkyphosis and @entity4 are not associated with prevalent @entity3 in @entity0 with XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity3 ( @entity3 ) are the clinical consequence of spinal @entity2 and may be associated with @entity4 and aggravated @entity5 . However, the relative importance of @entity3 as an underlying cause of @entity5 and @entity4 is not known. The aim of this study was to investigate the relationship between prevalent @entity3 and the size of @entity4 in @entity7 @entity0 . Thirty-six @entity0 , aged 74.6        8.3 years, were consecutively recruited from the @entity2 unit at Uppsala University Hospital. The @entity0 had 1-9 radiographic verified @entity3 . @entity6 ( @entity6 ) and numeric rating scale were used to measure @entity5 and @entity1 . All @entity0 had a hyperkyphosis ( @entity6   >=    10   cm). Notably, there were no associations between numbers or location of @entity3 versus size of @entity5 (     =   0.15, p   =   0.4;      =   -0.27, p   =   0.12) or severity of @entity4 (     =   -0.08, p   =   0.66;      =   0.16, p   =   0.35). Furthermore, no association was evident between @entity5 and @entity4 (     =   -0.02, p   =   0.89). There was, however, an association between size of @entity5 and age (R   =   0.44, p   =   0.008). In conclusion, these data suggest that prevalent @entity3 are not significantly associated with @entity5 or @entity4 , in @entity0 with manifest spinal @entity2 .

title: Hyperkyphosis and XXXX are not associated with prevalent @entity3 in @entity0 with @entity2 .

answer: @entity4


abstract: UNASSIGNED: @entity3 ( @entity3 ) are the clinical consequence of spinal @entity2 and may be associated with @entity4 and aggravated @entity5 . However, the relative importance of @entity3 as an underlying cause of @entity5 and @entity4 is not known. The aim of this study was to investigate the relationship between prevalent @entity3 and the size of @entity4 in @entity7 @entity0 . Thirty-six @entity0 , aged 74.6        8.3 years, were consecutively recruited from the @entity2 unit at Uppsala University Hospital. The @entity0 had 1-9 radiographic verified @entity3 . @entity6 ( @entity6 ) and numeric rating scale were used to measure @entity5 and @entity1 . All @entity0 had a hyperkyphosis ( @entity6   >=    10   cm). Notably, there were no associations between numbers or location of @entity3 versus size of @entity5 (     =   0.15, p   =   0.4;      =   -0.27, p   =   0.12) or severity of @entity4 (     =   -0.08, p   =   0.66;      =   0.16, p   =   0.35). Furthermore, no association was evident between @entity5 and @entity4 (     =   -0.02, p   =   0.89). There was, however, an association between size of @entity5 and age (R   =   0.44, p   =   0.008). In conclusion, these data suggest that prevalent @entity3 are not significantly associated with @entity5 or @entity4 , in @entity0 with manifest spinal @entity2 .

title: Hyperkyphosis and @entity4 are not associated with prevalent XXXX in @entity0 with @entity2 .

answer: @entity3


abstract: UNASSIGNED: @entity3 ( @entity3 ) are the clinical consequence of spinal @entity2 and may be associated with @entity4 and aggravated @entity5 . However, the relative importance of @entity3 as an underlying cause of @entity5 and @entity4 is not known. The aim of this study was to investigate the relationship between prevalent @entity3 and the size of @entity4 in @entity7 @entity0 . Thirty-six @entity0 , aged 74.6        8.3 years, were consecutively recruited from the @entity2 unit at Uppsala University Hospital. The @entity0 had 1-9 radiographic verified @entity3 . @entity6 ( @entity6 ) and numeric rating scale were used to measure @entity5 and @entity1 . All @entity0 had a hyperkyphosis ( @entity6   >=    10   cm). Notably, there were no associations between numbers or location of @entity3 versus size of @entity5 (     =   0.15, p   =   0.4;      =   -0.27, p   =   0.12) or severity of @entity4 (     =   -0.08, p   =   0.66;      =   0.16, p   =   0.35). Furthermore, no association was evident between @entity5 and @entity4 (     =   -0.02, p   =   0.89). There was, however, an association between size of @entity5 and age (R   =   0.44, p   =   0.008). In conclusion, these data suggest that prevalent @entity3 are not significantly associated with @entity5 or @entity4 , in @entity0 with manifest spinal @entity2 .

title: Hyperkyphosis and @entity4 are not associated with prevalent @entity3 in XXXX with @entity2 .

answer: @entity0


abstract: BACKGROUND: Reconstruction of chronic @entity1 poses a great challenge for the orthopaedic surgeon both technically and functionally. The aim of this study was to assess the results of a new technique for reconstruction of chronic @entity1 with defects longer than 5  cm using the @entity2 autograft wrapped in a central turndown flap from the proximal portion of the Achilles tendon. @entity0 AND METHODS: Eighteen @entity0 (14 female and 4 male; mean age, 40.7  years), having chronic @entity1 , were enrolled in this study. The mean follow-up period of our @entity0 was 21.8  months. All @entity0 were assessed via the following parameters: lag of interference since the first complaint, length of the defect, length of the turndown flap and length of the harvested plantaris tendon, surgery time, complications, active range of motion at the ankle and the final score. Average values were presented as means. Independent sample t test, Mann Whitney test, paired sample t test and Pearson's correlation coefficient were used to evaluate the clinical and functional results. The results were considered statistically significant if a P value was <0.05. To analyse the time course of the gap following surgery, the data from the first MRI session were compared with those from the second and third sessions using the Wilcoxon's signed rank test. In addition, the paired data of the tendon gap disappearance rate between T1-weighted and T2-weighted images were also compared using the McNemar test. RESULTS: The mean preoperative American Orthopaedic Foot and Ankle Society score was 62.2 points while at the @entity0 ' last follow-up, the mean postoperative score was 94.9 points. The results of this study confirmed that both the @entity2 have been perceived with higher sensitivity in T2-weighted images than in T1-weighted images. CONCLUSIONS: We believe that this new technique is biologic, synchronous and reliable in cases of chronic @entity1 with defects longer than 5  cm.

title: Functional and MRI follow-up after reconstruction of chronic XXXX using the @entity2 wrapped with central turndown flap: a case series.

answer: @entity1


abstract: BACKGROUND: Reconstruction of chronic @entity1 poses a great challenge for the orthopaedic surgeon both technically and functionally. The aim of this study was to assess the results of a new technique for reconstruction of chronic @entity1 with defects longer than 5  cm using the @entity2 autograft wrapped in a central turndown flap from the proximal portion of the Achilles tendon. @entity0 AND METHODS: Eighteen @entity0 (14 female and 4 male; mean age, 40.7  years), having chronic @entity1 , were enrolled in this study. The mean follow-up period of our @entity0 was 21.8  months. All @entity0 were assessed via the following parameters: lag of interference since the first complaint, length of the defect, length of the turndown flap and length of the harvested plantaris tendon, surgery time, complications, active range of motion at the ankle and the final score. Average values were presented as means. Independent sample t test, Mann Whitney test, paired sample t test and Pearson's correlation coefficient were used to evaluate the clinical and functional results. The results were considered statistically significant if a P value was <0.05. To analyse the time course of the gap following surgery, the data from the first MRI session were compared with those from the second and third sessions using the Wilcoxon's signed rank test. In addition, the paired data of the tendon gap disappearance rate between T1-weighted and T2-weighted images were also compared using the McNemar test. RESULTS: The mean preoperative American Orthopaedic Foot and Ankle Society score was 62.2 points while at the @entity0 ' last follow-up, the mean postoperative score was 94.9 points. The results of this study confirmed that both the @entity2 have been perceived with higher sensitivity in T2-weighted images than in T1-weighted images. CONCLUSIONS: We believe that this new technique is biologic, synchronous and reliable in cases of chronic @entity1 with defects longer than 5  cm.

title: Functional and MRI follow-up after reconstruction of chronic @entity1 using the XXXX wrapped with central turndown flap: a case series.

answer: @entity2


abstract: BACKGROUND: Platelet-derived growth factor-BB (PDGF-BB) is highly expressed in the renal tissues of @entity0 with @entity7 , and it plays an important role in the initiation and progression of @entity7 . The aim of this study was to evaluate the protective effects of root of Polygonum cuspidatum extract ( @entity11 ) on early renal glomerular proliferation in @entity8 (STZ)-induced @entity1 @entity2 . METHODS: @entity11 (100, 350 mg/kg/day) was administered to @entity1 @entity2 for 16 weeks. Blood @entity3 and @entity4 were measured. Renal histology, @entity5 ( @entity5 ), and @entity6 ( @entity6 ) expression levels were also examined. RESULTS: After 16 weeks of treatment with @entity11 , severe @entity9 and @entity4 were observed in the @entity1 @entity2 . The expressions levels of @entity5 and @entity6 proteins were significantly increased in the glomeruli of the @entity1 @entity2 . The expression levels of PDGF-BB and its receptor expressions were greatly increased in the glomeruli of the @entity1 @entity2 . However, @entity11 markedly reduced @entity4 in the @entity1 @entity2 . @entity11 inhibited @entity5 and @entity6 up-regulation and ameliorated PDGF-BB and PEGFR-Ss protein expression in the @entity1 @entity2 . In addition, the binding of PDGF-BB/PDGFR-Ss was inhibited by @entity11 as shown by an in vitro assay. CONCLUSIONS: These results suggest that @entity11 has an inhibitory effect on @entity10 in @entity7 via the inhibition of the interaction of PDGF-BB with its receptor. @entity11 may have beneficial effects in preventing the progression of @entity7 .

title: Root of Polygonum cuspidatum extract reduces progression of @entity7 via inhibition of platelet-derived growth factor-BB (PDGF-BB) and interaction with its receptor in XXXX -induced @entity1 @entity2 .

answer: @entity8


abstract: BACKGROUND: Platelet-derived growth factor-BB (PDGF-BB) is highly expressed in the renal tissues of @entity0 with @entity7 , and it plays an important role in the initiation and progression of @entity7 . The aim of this study was to evaluate the protective effects of root of Polygonum cuspidatum extract ( @entity11 ) on early renal glomerular proliferation in @entity8 (STZ)-induced @entity1 @entity2 . METHODS: @entity11 (100, 350 mg/kg/day) was administered to @entity1 @entity2 for 16 weeks. Blood @entity3 and @entity4 were measured. Renal histology, @entity5 ( @entity5 ), and @entity6 ( @entity6 ) expression levels were also examined. RESULTS: After 16 weeks of treatment with @entity11 , severe @entity9 and @entity4 were observed in the @entity1 @entity2 . The expressions levels of @entity5 and @entity6 proteins were significantly increased in the glomeruli of the @entity1 @entity2 . The expression levels of PDGF-BB and its receptor expressions were greatly increased in the glomeruli of the @entity1 @entity2 . However, @entity11 markedly reduced @entity4 in the @entity1 @entity2 . @entity11 inhibited @entity5 and @entity6 up-regulation and ameliorated PDGF-BB and PEGFR-Ss protein expression in the @entity1 @entity2 . In addition, the binding of PDGF-BB/PDGFR-Ss was inhibited by @entity11 as shown by an in vitro assay. CONCLUSIONS: These results suggest that @entity11 has an inhibitory effect on @entity10 in @entity7 via the inhibition of the interaction of PDGF-BB with its receptor. @entity11 may have beneficial effects in preventing the progression of @entity7 .

title: Root of Polygonum cuspidatum extract reduces progression of @entity7 via inhibition of platelet-derived growth factor-BB (PDGF-BB) and interaction with its receptor in @entity8 -induced XXXX @entity2 .

answer: @entity1


abstract: BACKGROUND: Platelet-derived growth factor-BB (PDGF-BB) is highly expressed in the renal tissues of @entity0 with @entity7 , and it plays an important role in the initiation and progression of @entity7 . The aim of this study was to evaluate the protective effects of root of Polygonum cuspidatum extract ( @entity11 ) on early renal glomerular proliferation in @entity8 (STZ)-induced @entity1 @entity2 . METHODS: @entity11 (100, 350 mg/kg/day) was administered to @entity1 @entity2 for 16 weeks. Blood @entity3 and @entity4 were measured. Renal histology, @entity5 ( @entity5 ), and @entity6 ( @entity6 ) expression levels were also examined. RESULTS: After 16 weeks of treatment with @entity11 , severe @entity9 and @entity4 were observed in the @entity1 @entity2 . The expressions levels of @entity5 and @entity6 proteins were significantly increased in the glomeruli of the @entity1 @entity2 . The expression levels of PDGF-BB and its receptor expressions were greatly increased in the glomeruli of the @entity1 @entity2 . However, @entity11 markedly reduced @entity4 in the @entity1 @entity2 . @entity11 inhibited @entity5 and @entity6 up-regulation and ameliorated PDGF-BB and PEGFR-Ss protein expression in the @entity1 @entity2 . In addition, the binding of PDGF-BB/PDGFR-Ss was inhibited by @entity11 as shown by an in vitro assay. CONCLUSIONS: These results suggest that @entity11 has an inhibitory effect on @entity10 in @entity7 via the inhibition of the interaction of PDGF-BB with its receptor. @entity11 may have beneficial effects in preventing the progression of @entity7 .

title: Root of Polygonum cuspidatum extract reduces progression of XXXX via inhibition of platelet-derived growth factor-BB (PDGF-BB) and interaction with its receptor in @entity8 -induced @entity1 @entity2 .

answer: @entity7


abstract: BACKGROUND: Platelet-derived growth factor-BB (PDGF-BB) is highly expressed in the renal tissues of @entity0 with @entity7 , and it plays an important role in the initiation and progression of @entity7 . The aim of this study was to evaluate the protective effects of root of Polygonum cuspidatum extract ( @entity11 ) on early renal glomerular proliferation in @entity8 (STZ)-induced @entity1 @entity2 . METHODS: @entity11 (100, 350 mg/kg/day) was administered to @entity1 @entity2 for 16 weeks. Blood @entity3 and @entity4 were measured. Renal histology, @entity5 ( @entity5 ), and @entity6 ( @entity6 ) expression levels were also examined. RESULTS: After 16 weeks of treatment with @entity11 , severe @entity9 and @entity4 were observed in the @entity1 @entity2 . The expressions levels of @entity5 and @entity6 proteins were significantly increased in the glomeruli of the @entity1 @entity2 . The expression levels of PDGF-BB and its receptor expressions were greatly increased in the glomeruli of the @entity1 @entity2 . However, @entity11 markedly reduced @entity4 in the @entity1 @entity2 . @entity11 inhibited @entity5 and @entity6 up-regulation and ameliorated PDGF-BB and PEGFR-Ss protein expression in the @entity1 @entity2 . In addition, the binding of PDGF-BB/PDGFR-Ss was inhibited by @entity11 as shown by an in vitro assay. CONCLUSIONS: These results suggest that @entity11 has an inhibitory effect on @entity10 in @entity7 via the inhibition of the interaction of PDGF-BB with its receptor. @entity11 may have beneficial effects in preventing the progression of @entity7 .

title: Root of Polygonum cuspidatum extract reduces progression of @entity7 via inhibition of platelet-derived growth factor-BB (PDGF-BB) and interaction with its receptor in @entity8 -induced @entity1 XXXX .

answer: @entity2


abstract: AIM: A phospholipid complex (TFH-PC) was prepared to increase the oral bioavailability of @entity7 , @entity6 , and @entity2 from TFH (total @entity3 of Hippophae rhamnoides L.). METHODS: Solvent evaporation was used to prepare TFH-PC. Relevant parameters were investigated based on the complexation rate of @entity7 , @entity6 , and @entity2 . Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray power diffraction (X-RPD), and scanning electron microscopy (SEM) were used for characterization. Solubility, @entity5 -water partition coefficient (log P), dissolution rate, and in vivo pharmacokinetics were also investigated. RESULTS: TFH-PC was successfully prepared in @entity4 with a drug to phospholipid ratio of 1:1, reaction temperature of 20     C, and a reaction time of 1   h. The complexation rates of @entity7 , @entity6 , and @entity2 were 97.7%, 95.97%, and 92.23%, respectively. FT-IR, DSC, X-RPD, and SEM confirmed the formation of TFH-PC. The aqueous solubilities of the three @entity1 in TFH-PC increased 22.0-26.8-fold compared with TFH. The dissolution of @entity7 , @entity6 , and @entity2 in TFH-PC was 84.32%, 90.77%, and 100% within 10   min, respectively, greatly improved over TFH. After oral administration of TFH-PC in @entity0 , the bioavailability of @entity7 , @entity6 , and @entity2 in TFH-PC relative to TFH was 223%, 172%, and 242%, respectively. CONCLUSION: The oral absorption of @entity7 , @entity6 , and @entity2 was significantly improved in TFH-PC, mainly due to increased solubility and dissolution rate. This phospholipid complex shows potential for oral delivery of the @entity1 in TFH.

title: A phospholipid complex to improve the oral bioavailability of XXXX .

answer: @entity1


abstract: BACKGROUND: The aim of this study was to evaluate the complications associated with the occurrence and treatment of impacted maxillary @entity2 . METHODS: This retrospective study was conducted on 533 Southern Chinese @entity0 and adolescents who attended the Paediatric Dentistry and Orthodontics Clinics and had at least one impacted maxillary @entity2 . The study material included all the documentation files and radiographs of these @entity0 . Complications that had been recorded in the clinical and surgical notes and that could be diagnosed from the available radiographs were noted. The data obtained were descriptively analyzed. RESULTS: The most frequently reported phenomenon associated with the occurrence of impacted maxillary @entity2 (prior to surgical treatment) was root resorption of an adjacent permanent tooth in 22 (4.1%) @entity0 . The most frequently reported sequelae observed after any surgical procedure was swelling of the soft tissues around the operation site which often persisted for 48h as seen in 76 (18.8%) @entity0 . Complications reported most commonly after any form of surgery included @entity3 : 7(1.7%), @entity4 : 7(1.7%), post-operative @entity1 : 6(1.5%) and purulent discharge: 6(1.5%), post-operative complications in relation to surgical exposure and bonding of an attachment which included breakage of ligature wire: 5.7%; de-bonding of the attachment: 4.3% and inability to bond the attachment during surgery: 1.4% occurred rarely. CONCLUSIONS: The frequency of root resorption of teeth adjacent to an impacted maxillary @entity2 was low. Swelling of the soft tissue 48h post-operatively was the most commonly occurring complication after surgical intervention.

title: Complications associated with the occurrence and treatment of impacted maxillary XXXX .

answer: @entity2


abstract: BACKGROUND: Anthropogenic disturbances can lead to intense selection pressures on traits and very rapid evolutionary changes. Evolutionary responses to environmental changes, in turn, reflect changes in the genetic structure of the traits, accompanied by a reduction of evolutionary potential of the populations under selection. Assessing the effects of pollutants on the evolutionary responses and on the genetic structure of populations is thus important to understanding the mechanisms that entail specialization to novel environmental conditions or resistance to novel stressors. RESULTS: Using an experimental evolution approach we exposed @entity1 populations to @entity0 , salt and alternating @entity0 -salt environments over 22 generations. We analyzed the changes in the average values of life history traits and the consequences at the demographic level in these populations. We also estimated the phenotypic and genetic (co)variance structure of these traits at different generations. Compared to populations in salt, populations in @entity0 showed a reduction of the stability of their trait structure and a higher capacity to respond by acclimation. However, the evolutionary responses of traits were generally lower for @entity0 compared to salt treatment; and the evolutionary responses to the alternating @entity0 -salt environment were between those of constant environments. Consequently, at the end of the experiment, the population rate of increase was higher in @entity0 than in salt and intermediate in the alternating environment. CONCLUSIONS: Our multigenerational experiment confirmed that rapid adaptation to different polluted environments may involve different evolutionary responses resulting in demographic consequences. These changes are partly explained by the effects of the pollutants on the genetic (co)variance structure of traits and the capacity of acclimation to novel conditions. Finally, our results in the alternating environment may confirm the selection of a generalist type in this environment.

title: Rapid evolutionary responses of life history traits to different experimentally-induced pollutions in XXXX .

answer: @entity1


abstract: BACKGROUND: We describe the experimental design for a methodological approach to determine whether directed adaptive mutation occurs in @entity0 cells. Identification of directed adaptive mutation would have profound practical significance for a wide variety of biomedical problems, including disease development and resistance to treatment. In adaptive mutation, the genetic or epigenetic change is not random; instead, the presence and type of selection influences the frequency and character of the mutation event. Adaptive mutation can contribute to the evolution of microbial pathogenesis, @entity1 , and drug resistance, and may become a focus of novel therapeutic interventions. OBJECTIVE: Our experimental approach was designed to distinguish between 3 types of mutation: (1) random mutations that are independent of selective pressure, (2) undirected adaptive mutations that arise when selective pressure induces a general increase in the mutation rate, and (3) directed adaptive mutations that arise when selective pressure induces targeted mutations that specifically influence the adaptive response. The purpose of this report is to introduce an experimental design and describe limited pilot experiment data (not to describe a complete set of experiments); hence, it is an early report. METHODS: An experimental design based on immortalization of @entity2 embryonic fibroblast cells is presented that links clonal cell growth to reversal of an inactivating polyadenylation site mutation. Thus, cells exhibit growth only in the presence of both the countermutation and an inducing agent ( @entity3 ). The type and frequency of mutation in the presence or absence of @entity3 will be evaluated. Additional experimental approaches would determine whether the cells exhibit a generalized increase in mutation rate and/or whether the cells show altered expression of error-prone DNA polymerases or of mismatch repair proteins. RESULTS: We performed the initial stages of characterizing our system and have limited preliminary data from several pilot experiments. Cell growth and DNA sequence data indicate that we have identified a cell clone that exhibits several suitable characteristics, although further study is required to identify a more optimal cell clone. CONCLUSIONS: The experimental approach is based on a quantum biological model of basis-dependent selection describing a novel mechanism of adaptive mutation. This project is currently inactive due to lack of funding. However, consistent with the objective of early reports, we describe a proposed study that has not produced publishable results, but is worthy of report because of the hypothesis, experimental design, and protocols. We outline the project's rationale and experimental design, with its strengths and weaknesses, to stimulate discussion and analysis, and lay the foundation for future studies in this field.

title: Experimental design to evaluate directed adaptive mutation in XXXX cells.

answer: @entity0


abstract: We present two cases of concurrent development of @entity10 ( @entity10 ) with @entity4 ( @entity4 ) and one related to clonal B-cell @entity12 ( @entity11 ). Both @entity0 were referred for @entity12 and @entity5 . A bone marrow biopsy revealed infiltration of small, mature lymphocytes and @entity6 . Flow cytometric immunophenotyping and immunoglobulin (IG) gene clonality tests revealed clonal B lymphocytes. Both @entity0 were positive for the @entity8 @entity9 mutation in whole bone marrow aspirate. The @entity8 @entity9 mutation was present in isolated B lymphocytes of @entity0 1, but not @entity0 2. Cytogenetics were normal in both @entity0 . An array comparative genomic hybridization (CGH) analyses of B cells revealed a gain of 4q28.3, which is reported in @entity7 , in @entity0 1, and deletion 22q11.22, which is associated with @entity4 , and a gain of Xp22.31 in @entity0 2. In both @entity0 , B cells showed no @entity1 ( @entity1 )-specific @entity2 . These results suggest that different oncogenic mechanisms in each cell lineage may underlie the concurrent development of @entity10 and @entity4 (or @entity11 ). Array CGH may be helpful in identifying the pathogenic mechanism in cases of concurrent development of @entity3 and @entity1 .

title: Two cases of concurrent development of @entity10 with XXXX , one related to clonal B-cell @entity12 , tested by array comparative genomic hybridization.

answer: @entity4


abstract: We present two cases of concurrent development of @entity10 ( @entity10 ) with @entity4 ( @entity4 ) and one related to clonal B-cell @entity12 ( @entity11 ). Both @entity0 were referred for @entity12 and @entity5 . A bone marrow biopsy revealed infiltration of small, mature lymphocytes and @entity6 . Flow cytometric immunophenotyping and immunoglobulin (IG) gene clonality tests revealed clonal B lymphocytes. Both @entity0 were positive for the @entity8 @entity9 mutation in whole bone marrow aspirate. The @entity8 @entity9 mutation was present in isolated B lymphocytes of @entity0 1, but not @entity0 2. Cytogenetics were normal in both @entity0 . An array comparative genomic hybridization (CGH) analyses of B cells revealed a gain of 4q28.3, which is reported in @entity7 , in @entity0 1, and deletion 22q11.22, which is associated with @entity4 , and a gain of Xp22.31 in @entity0 2. In both @entity0 , B cells showed no @entity1 ( @entity1 )-specific @entity2 . These results suggest that different oncogenic mechanisms in each cell lineage may underlie the concurrent development of @entity10 and @entity4 (or @entity11 ). Array CGH may be helpful in identifying the pathogenic mechanism in cases of concurrent development of @entity3 and @entity1 .

title: Two cases of concurrent development of @entity10 with @entity4 , one related to clonal B-cell XXXX , tested by array comparative genomic hybridization.

answer: @entity12


abstract: We present two cases of concurrent development of @entity10 ( @entity10 ) with @entity4 ( @entity4 ) and one related to clonal B-cell @entity12 ( @entity11 ). Both @entity0 were referred for @entity12 and @entity5 . A bone marrow biopsy revealed infiltration of small, mature lymphocytes and @entity6 . Flow cytometric immunophenotyping and immunoglobulin (IG) gene clonality tests revealed clonal B lymphocytes. Both @entity0 were positive for the @entity8 @entity9 mutation in whole bone marrow aspirate. The @entity8 @entity9 mutation was present in isolated B lymphocytes of @entity0 1, but not @entity0 2. Cytogenetics were normal in both @entity0 . An array comparative genomic hybridization (CGH) analyses of B cells revealed a gain of 4q28.3, which is reported in @entity7 , in @entity0 1, and deletion 22q11.22, which is associated with @entity4 , and a gain of Xp22.31 in @entity0 2. In both @entity0 , B cells showed no @entity1 ( @entity1 )-specific @entity2 . These results suggest that different oncogenic mechanisms in each cell lineage may underlie the concurrent development of @entity10 and @entity4 (or @entity11 ). Array CGH may be helpful in identifying the pathogenic mechanism in cases of concurrent development of @entity3 and @entity1 .

title: Two cases of concurrent development of XXXX with @entity4 , one related to clonal B-cell @entity12 , tested by array comparative genomic hybridization.

answer: @entity10


abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity0 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity3 PET tracers frequently used in the clinic, @entity6 , @entity8 , and @entity9 , in a preclinical @entity0 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity0 ( @entity0 ), spatial reproducibility, and sensitivity to @entity1 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity4 R1-bearing WAG/Rij @entity2 were acquired at multiple time points post injection (p.i.) with one of the @entity3 tracers. @entity0 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity1 modifications were induced by exposure to either @entity7 / @entity5 treatment or 7% @entity1 breathing. RESULTS: @entity0 was stabilized and maximal at 2 hours p.i. for @entity8 (4.0    0.5) and at 3 hours p.i. for @entity9 (7.2    0.7), whereas @entity6 showed a constant increasing @entity0 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity6 (R = 0.86; Dice coefficient = 0.76) and @entity9 (R = 0.76; Dice coefficient = 0.70), whereas @entity8 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity3 fraction resulted in enhanced mean standardized uptake values for both @entity9 and @entity8 upon 7% @entity1 breathing. Only @entity6 uptake was found to be reversible upon exposure to @entity5 and @entity7 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the XXXX PET Tracers @entity9 , @entity8 , and @entity6 in a Preclinical Tumor Model.

answer: @entity3


abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity0 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity3 PET tracers frequently used in the clinic, @entity6 , @entity8 , and @entity9 , in a preclinical @entity0 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity0 ( @entity0 ), spatial reproducibility, and sensitivity to @entity1 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity4 R1-bearing WAG/Rij @entity2 were acquired at multiple time points post injection (p.i.) with one of the @entity3 tracers. @entity0 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity1 modifications were induced by exposure to either @entity7 / @entity5 treatment or 7% @entity1 breathing. RESULTS: @entity0 was stabilized and maximal at 2 hours p.i. for @entity8 (4.0    0.5) and at 3 hours p.i. for @entity9 (7.2    0.7), whereas @entity6 showed a constant increasing @entity0 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity6 (R = 0.86; Dice coefficient = 0.76) and @entity9 (R = 0.76; Dice coefficient = 0.70), whereas @entity8 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity3 fraction resulted in enhanced mean standardized uptake values for both @entity9 and @entity8 upon 7% @entity1 breathing. Only @entity6 uptake was found to be reversible upon exposure to @entity5 and @entity7 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the @entity3 PET Tracers XXXX , @entity8 , and @entity6 in a Preclinical Tumor Model.

answer: @entity9