abstract: Out of 2.513 clinical files of @entity1 @entity0 , we have found 200 pollen- @entity1 @entity0 , which represent 7.9% of the total @entity1 pathology in @entity0 , in our environment. We have studied in these 200, the most important epidemiological parameters and the influence that this can cause upon the characteristics of this disease. A male predominance has been found (70%) and it has been discovered that 52% of the total were born in spring (p less than 0.0005). An hundred per cent have shown grass-pollen sensitiveness and 52% have also shown other kinds of pollen @entity1 . It has been found familiar @entity1 background in 76.5% of the cases and in 32.5% familiar @entity1 history of @entity5 . Unexpectedly, those who were in lack of familiar @entity1 history began their clinical symptoms earlier; 51.06% before 6 years of age (p less than 0.05). Other kinds of @entity1 manifestations were found in 51%, being respiratory symptoms the most important (35.5%), followed by the cutaneous (23.5%) and digestive ones (10.5%). Allergy to drugs was found in 10.5%. The more frequent symptoms of @entity5 were in order of importance: @entity7 (86.5%), @entity6 (77%), @entity3 (48%), spasmodic cough (27.5%) and @entity2 (4%). @entity3 induced by grass-pollen @entity1 was equally suffered by the males as by the females, and this was more frequent among the @entity0 who had previously suffered from @entity4 .

title: [Natural history of XXXX in childhood].

answer: @entity5


abstract: Unlike its cutaneous counterpart, prognostic markers for primary @entity1 have not been well elucidated. It has been recently demonstrated that microvascular density (MVD) in @entity1 has a significant negative correlation with survival; however, this has not been well-studied in @entity1 of the head and neck. This study explores the potential association between MVD, various histological parameters, and the outcome of a series of @entity3 . Nineteen such cases were immunostained with @entity2 and the MVD was calculated by using Bioquant Image Analysis Software (R and M Biometrics, Nashville, @entity4 ). These cases included 16 sinonasal and 3 oral @entity0 . The 1, 2, 3, 4 and 5  years overall survival rates were 75, 57, 61, 46 and 46%, respectively. The MVD of the @entity0 ranged from 25.7 to 732 vessels/mm(2) (mean 142.8 vessels/mm(2); median 84.7 vessels/mm(2)). There was no significant correlation between the MVD and the different clinicopathological features seen within the @entity0 . There was also no correlation between the MVD and relapse free and overall survival. The results of this study suggest that MVD does not correlate with outcome in @entity1 of the head and neck as seen in cutaneous @entity1 . Further larger studies are needed to identify predictive and prognostic markers in such @entity1 .

title: Lack of correlation between microvascular density and pathological features and outcomes in XXXX .

answer: @entity3


abstract: @entity5 ( @entity5 ) is frequently encountered in @entity0 . The clinical manifestation ranges from no impairment in light cases to @entity3 due to right-sided @entity4 or hypoxaemia in severe cases. Occasionally, @entity5 can give rise to a @entity7 ( @entity7 ), which is marked by @entity2 , @entity6 , @entity3 . It is well known that @entity1 of long bones can lead to @entity5 . Several authors have argued that @entity5 can arise due to mere soft tissue injury in the absence of @entity1 , a claim other authors disagree upon. In this study, we retrospectively examined 50 victims of @entity0 with regard to grade and extent of @entity1 and crushing of subcutaneous fatty tissue and presence and severity of @entity5 . Our results indicate that @entity5 can arise due to mere crushing of subcutaneous fat and that the @entity1 grade correlated well with @entity5 severity (p   =   0.011). The correlation between @entity5 and the @entity1 severity (body regions affected by @entity1 and @entity1 grade) showed a lesser significant correlation (p   =   0.170). The survival time (p   =   0.567), the amount of body regions affected by fat crushing (p   =   0.336) and the fat crush grade (p   =   0.485) did not correlate with the @entity5 grade, nor did the amount of body regions affected by @entity1 . These results may have clinical implications for the assessment of a possible @entity7 development, as, if the risk of a @entity5 is known, preventive steps can be taken.

title: Correlation of fat embolism severity and XXXX .

answer: @entity1


abstract: INTRODUCTION: Sigmoid resection is now considered as a standard procedure for acute and recurrent @entity1 ( @entity1 ). In the last decade significant changes in preoperative diagnosis with computed tomography (CT) scanning and surgical access (laparoscopy) have been implemented. The aim of this study was to examine whether this has led to changes in the indications for surgical therapy. @entity0 AND METHODS: Consecutive admissions of 1,154 @entity0 from January 1995 to December 2009 with acute @entity1 were prospectively included. In terms of pre-operative and intraoperative findings and postoperative course 3 treatment periods (TP) were distinguished: TP I 1995-1999, TP II 2000-2004 and TP III 2005-2009. RESULTS: CT scanning was used in more than 90% of cases since TP II compared to 51% during TP I (p<0.001). The ratio of emergency versus elective surgery significantly increased in favor of elective surgery (p<0.001). The rate of laparoscopy-assisted sigmoid resections showed a continuous increase from 53% in TP I to 71% in TP III (p<0.001) while the rate of Hartmann's procedures decreased over time (p<0.001). Overall, the rate of surgically treated @entity0 decreased during the time periods studied despite an increase in the total number of @entity0 with @entity1 (TP III versus TP I +41%.) The rate of conservatively treated @entity0 increased significantly (p<0.001). The morbidity rate decreased (p<0,001) whereas mortality rates remained at a constantly low level (p=0.175). CONCLUSION: The increasing use of CT diagnosis and the laparoscopic approach led to a shift from emergency surgery with a high complication rate to elective surgery with a high rate of primary restoration of continuity and low morbidity. However, the indications for surgery and therefore the overall rate of @entity0 who underwent surgery did not increase due to these changes.

title: [Acute XXXX . Are operations more frequent since the introduction of laparoscopy and CT scanning?].

answer: @entity1


abstract: Serial venom antigen levels were measured by enzyme-linked immunosorbent assay (ELISA) in 46 @entity0 with systemic envenoming by the Malayan pit viper (Calloselasma rhodostoma), a major cause of snake bite in Southeast Asia. The principal effects of the venom are defibrination, @entity2 and local tissue @entity1 . Admission venom levels, which varied between 0 and 595 ng/ml, correlated with the incidence of spontaneous @entity2 , @entity3 and concentrations of plasma @entity4 and serum fibrin degradation products. The presence or absence of nonclotting blood also correlated with the time elapsed between the bite and hospital admission. The development of nonclotting blood may be delayed by up to 72 hr after the bite even though circulating venom and raised FDP may be detected at presentation. This is probably explained by a temporary equilibrium between synthesis and consumption of @entity4 . Venom antigenemia recurred in 12 @entity0 (26%) suggesting continuous absorption of venom from the wound or saturation of extravascular binding sites. Admission venom levels also correlated with the extent of local swelling and the occurrence of tissue @entity1 at the site of the bite. Venom was detected in 87% of wound aspirates and 88% of urine specimens taken on admission. Tourniquets, of the type used in rural Thailand, did not delay the absorption of venom into the circulation.

title: Clinical significance of venom antigen levels in XXXX envenomed by the Malayan pit viper (Calloselasma rhodostoma).

answer: @entity0


abstract: INTRODUCTION: Cardiovascular (CV) morbidity and mortality are greatly enhanced in @entity0 with @entity4 , partly due to increased arterial @entity9 . MATERIAL AND METHOD: The study included 63 stable @entity8 @entity0 . Stiffness parameters were evaluated by applanation tonometry before the mid-week @entity8 sessions. Pre- @entity8 bioimpedance parameters were measured. A phase angle <six degrees was previously reported as abnormal, reflecting extracellular @entity11 . Fluid status was evaluated echocardiographic by measuring the inferior vena cava (IVC) diameter. Endothelium-dependent and endothelium-independent vascular reactivity were assessed by changes in @entity13 following sublingual @entity6 and inhaled @entity10 . RESULTS: @entity2 directly correlated with @entity0 ' age and dialysis vintage. @entity0 with a phase angle <6  , were significantly overhydrated (larger IVC, increased ECW, and lower ICW), had stiffer arteries and greater @entity12 ( @entity12 ), compared with those with a phase angle >6  . Overhydration increases arterial @entity9 , but has no influence on either EID or ED vascular reactivity. CONCLUSION: In hemodialysis, @entity7 is an important contributor to increased arterial @entity9 and modifies @entity1 especially by @entity5 . Achieving normohydration may significantly ameliorate @entity3 and arterial @entity9 and may impact major clinical events and CV mortality.

title: Changes in arterial XXXX following dialysis in relation to @entity11 and to endothelial function.

answer: @entity9


abstract: INTRODUCTION: Cardiovascular (CV) morbidity and mortality are greatly enhanced in @entity0 with @entity4 , partly due to increased arterial @entity9 . MATERIAL AND METHOD: The study included 63 stable @entity8 @entity0 . Stiffness parameters were evaluated by applanation tonometry before the mid-week @entity8 sessions. Pre- @entity8 bioimpedance parameters were measured. A phase angle <six degrees was previously reported as abnormal, reflecting extracellular @entity11 . Fluid status was evaluated echocardiographic by measuring the inferior vena cava (IVC) diameter. Endothelium-dependent and endothelium-independent vascular reactivity were assessed by changes in @entity13 following sublingual @entity6 and inhaled @entity10 . RESULTS: @entity2 directly correlated with @entity0 ' age and dialysis vintage. @entity0 with a phase angle <6  , were significantly overhydrated (larger IVC, increased ECW, and lower ICW), had stiffer arteries and greater @entity12 ( @entity12 ), compared with those with a phase angle >6  . Overhydration increases arterial @entity9 , but has no influence on either EID or ED vascular reactivity. CONCLUSION: In hemodialysis, @entity7 is an important contributor to increased arterial @entity9 and modifies @entity1 especially by @entity5 . Achieving normohydration may significantly ameliorate @entity3 and arterial @entity9 and may impact major clinical events and CV mortality.

title: Changes in arterial @entity9 following dialysis in relation to XXXX and to endothelial function.

answer: @entity11


abstract: In developing lymphocytes, the recombination activating gene endonuclease cleaves DNA between V, D, or J coding and @entity5 ( @entity5 ) sequences to form hairpin coding and blunt @entity5 ends, which are fused to form coding and @entity5 joins. Nonhomologous end joining (NHEJ) factors repair DNA double strand breaks including those induced during VDJ recombination. @entity0 radiosensitive severe @entity2 results from lack of Artemis function, an NHEJ factor with in vitro endonuclease/exonuclease activities. We inactivated Artemis in @entity1 @entity4 ( @entity4 ) cells by targeted mutation. @entity3 results in impaired VDJ coding, but not @entity5 , end joining. In addition, Artemis-deficient @entity4 cells are sensitive to a radiomimetic drug, but less sensitive to ionizing radiation. VDJ coding joins from Artemis-deficient @entity4 cells, which surprisingly are distinct from the highly deleted joins consistently obtained from DNA-dependent protein kinase catalytic subunit-deficient @entity4 cells, frequently lack deletions and often display large junctional palindromes, consistent with a hairpin coding end opening defect. Strikingly, Artemis-deficient @entity4 cells have increased chromosomal instability including telomeric fusions. Thus, Artemis appears to be required for a subset of NHEJ reactions that require end processing. Moreover, Artemis functions as a genomic caretaker, most notably in prevention of translocations and telomeric fusions. As @entity3 is compatible with @entity0 life, Artemis may also suppress genomic instability in @entity0 .

title: Defective DNA repair and increased genomic instability in Artemis-deficient XXXX cells.

answer: @entity1


abstract: The two main tasks of a meristem, self-perpetuation and organ initiation, are separated spatially. Slowly dividing cells in the meristem center act as pluripotent stem cells, and only their derivatives in the meristem periphery specify new organs. Meristem integrity and cellular proliferation are controlled in part by regulatory interactions between genes that are expressed in specific subdomains of the meristem. Using transposon-mediated activation tagging, we have identified Dornr  schen ( @entity4 -D) mutants of @entity0 that prematurely arrest shoot meristem activity with the formation of radialized lateral organs. The mutated gene ( @entity4 / @entity4 ), which encodes an @entity1 /ERF protein, is expressed in a subdomain of meristem stem cells, in lateral organ anlagen, and transiently in the distal domain of organ primordia. During the development of @entity4 -D mutants, expression of the homeobox gene SHOOTMERISTEMLESS is downregulated and later reactivated in an altered domain. In addition, we found increased expression of @entity3 and @entity2 , two genes that antagonistically regulate stem cell fate in meristems. These findings suggest that the @entity4 / @entity4 gene product is involved in the regulation of gene expression patterns in meristems. Furthermore, specific misexpression of @entity4 in meristem stem cells affects organ polarity and outgrowth in the meristem periphery, indicating that @entity4 / @entity4 itself, or a process regulated by @entity4 / @entity4 , can act non-cell-autonomously. We elaborate on the role of @entity4 / @entity4 in meristem and organ development and discuss its possible role in the process of shoot regeneration.

title: The DORNROSCHEN/ENHANCER OF SHOOT REGENERATION1 gene of XXXX acts in the control of meristem ccll fate and lateral organ development.

answer: @entity0


abstract: Lead subacetate (0.5g) and 1000 units of @entity3 were given three times a week to four newly-weaned @entity5 . In addition, two animals received only the @entity3 . The poisoned animals had an increase in the urinary excretion of @entity6 , an elevated content of lead in the blood, and a fall in hemoglobin concentration. Between 6 and 18 weeks the animals suddenly developed @entity4 , @entity1 , generalized weakness, and @entity2 . At this time the animals were killed by perfusion of fixative and the brain prepared for light and electron microscopic studies. Definite morphological evidence of disease was confined to the central nervous system, except for one animal which showed the characteristic renal inclusions of @entity7 . All animals showed PAS-positive globules associated with blood vessels and an exudative @entity0 involving the white matter of the cerebral hemispheres and cerebellum. Ultra-structurally, this appeared as a granular precipitate within an expanded extracellular space. Alterations of nerve fibers were not seen in the white matter but axonal swelling was observed in the cerebral cortex. The perikaryon and neuropil appeared normal. The control animals showed no significant cerebral changes.

title: Experimental acute lead encephalopathy in the juvenile XXXX .

answer: @entity5


abstract: BACKGROUND: @entity2 ( @entity2 ) in young @entity0 is associated with a poor outcome due to advanced stage at diagnosis and poor differentiation. AIM: The aim of this study is to compare clinicopathological characteristics, @entity3 ( @entity3 ) and disease-free survival (DFS) of young ( <=40 years) and older @entity0 with @entity2 . METHODS: A total of 2,538 @entity0 including 59 young @entity0 (age  <=40 years) with @entity2 were identified over 20 years. The clinicopathological variables of young @entity0 were compared with a group of consecutive older @entity0 (n = 416) spanning both decades. Survival analysis was done using Kaplan-Meier, log-rank and Cox regression models. RESULTS: The frequency in young @entity0 increased from 1.4% to 3.0% from first to second decade (overall -2.3%, p = 0.006). There was a higher frequency of @entity1 with poor differentiation (43% vs. 16%, p = < 0.001), T4 stage (47% vs. 30%, p = 0.005) and vascular invasion (VI; 38% vs. 29%, p = 0.13) in younger group. There was no significant difference in @entity3 (p = 0.116) and DFS (p = 0.261) between the two groups. Node-negative young @entity0 had a significantly better @entity3 (p = 0.046). Young @entity0 with VI had significantly reduced @entity3 (p = 0.043), whereas young @entity0 without VI had significantly better @entity3 (p = 0.012). Multivariate analysis showed T4 status (p = 0.001) and vascular invasion (p = 0.002) as independent prognostic factors for @entity3 and T4 status (p = 0.004) as independent factor influencing DFS. CONCLUSION: The frequency of @entity2 in young @entity0 increased significantly. Vascular invasion is the single most important prognostic factor in young @entity2 . Along with vascular invasion, high proportion of T4 status in young @entity0 increases the chances of recurrence and negates any survival advantage in young @entity0 .

title: XXXX in the young: trends, characteristics and outcome.

answer: @entity2


abstract: OBJECTIVE To determine long-term (>10 years) visual outcome in @entity0 with @entity4 . METHODS Retrospective case series.RESULTS Among 18 @entity0 who underwent surgery for @entity4 (1 @entity0 died postoperatively), 1 experienced initial improvement in vision in both eyes, 8 experienced improvement in vision in one eye and maintained stable vision in the other eye, 2 experienced @entity2 in the other, 3 experienced worsening of @entity2 in one eye, and 4 maintained stable visual acuity in both eyes. No @entity0 experienced postoperative @entity2 . During 10 years or more of follow-up, 10 of the @entity0 (56%) maintained stable vision in both eyes, 6 @entity0 (33%) experienced @entity3 in one eye while maintaining stable vision in the other, and 2 @entity0 (11%) experienced @entity3 in both eyes. During this period, 7 of the 18 @entity0 (39%) developed neuroimaging evidence of @entity1 growth or recurrence, with a mean time of 10.7 years. Four of these @entity0 were thought to have had gross total resection of their @entity1 . @entity0 who experienced worsening of vision during the follow-up period were more likely to have developed neuroimaging evidence of growth or recurrence (five @entity0 ) than @entity0 without such evidence (two @entity0 ), and such @entity0 did not regain vision following subsequent surgery or radiation therapy. Nevertheless, at final examination, 13 @entity0 (72%) had visual acuity of 20/40 or better in at least one eye. CONCLUSIONS The long-term visual prognosis for @entity0 who undergo surgery for @entity4 is excellent, although @entity1 recurrence is common, even in @entity0 thought to have undergone gross total @entity1 , and often occurs more than 10 years after surgery. @entity0 who develop @entity1 recurrence are likely to lose vision in at least one eye and are unlikely to achieve improvement in vision with subsequent surgery or radiation therapy. Thus, @entity0 with @entity4 believed to have been completely resected should undergo long-term, serial postoperative clinical examinations and neuroimaging to allow detection and further treatment of recurrences as early as possible. Postoperative radiation therapy should be considered for @entity0 whose @entity4 have been incompletely resected.

title: Visual outcome in surgically treated XXXX .

answer: @entity4


abstract: Thirty HLA-A2 @entity1 with metastatic @entity0 received up to 14 vaccinations with MDA-MB-231- @entity8 , an HLA-A2 allogeneic @entity0 cell line, which had been lipofected with the cDNA for the @entity8 costimulatory molecule. @entity2 cells were administered with BCG or @entity7 as an adjuvant. Sera obtained before and after vaccination were analyzed for antibodies to @entity2 cell lysate, @entity6 , @entity4 / @entity4 and @entity3 . Since the cell line was grown in @entity5 ( @entity5 ), sera were also analyzed for antibodies to @entity5 . Eighteen of 24 @entity1 for whom sera were available exhibited anti- @entity5 activity at baseline. Eleven of these 18 @entity1 and all six @entity1 without baseline anti- @entity5 activity showed an increased titer after vaccination. The anti- @entity5 activity required that serum samples be absorbed in excess @entity5 to detect specific antibodies to @entity2 cell lysate. A two-fold increase in the titer of IgG specific to @entity2 cell lysate was observed in 6 @entity1 . Eight of 24 @entity1 made an antibody response to @entity4 , four of 24 to @entity6 and one of 24 to @entity3 . Although antibody production to a variety of @entity2 cell-associated antigens was detected our results suggest that a whole cell vaccine comprising a @entity8 -transfected allogeneic @entity0 cell line with adjuvant BCG or @entity7 was not a reliable method to induce significant antibody responses in @entity1 with @entity0 .

title: Identification of @entity2 -specific antibodies in @entity1 with XXXX vaccinated with gene-modified @entity2 cells.

answer: @entity0


abstract: Thirty HLA-A2 @entity1 with metastatic @entity0 received up to 14 vaccinations with MDA-MB-231- @entity8 , an HLA-A2 allogeneic @entity0 cell line, which had been lipofected with the cDNA for the @entity8 costimulatory molecule. @entity2 cells were administered with BCG or @entity7 as an adjuvant. Sera obtained before and after vaccination were analyzed for antibodies to @entity2 cell lysate, @entity6 , @entity4 / @entity4 and @entity3 . Since the cell line was grown in @entity5 ( @entity5 ), sera were also analyzed for antibodies to @entity5 . Eighteen of 24 @entity1 for whom sera were available exhibited anti- @entity5 activity at baseline. Eleven of these 18 @entity1 and all six @entity1 without baseline anti- @entity5 activity showed an increased titer after vaccination. The anti- @entity5 activity required that serum samples be absorbed in excess @entity5 to detect specific antibodies to @entity2 cell lysate. A two-fold increase in the titer of IgG specific to @entity2 cell lysate was observed in 6 @entity1 . Eight of 24 @entity1 made an antibody response to @entity4 , four of 24 to @entity6 and one of 24 to @entity3 . Although antibody production to a variety of @entity2 cell-associated antigens was detected our results suggest that a whole cell vaccine comprising a @entity8 -transfected allogeneic @entity0 cell line with adjuvant BCG or @entity7 was not a reliable method to induce significant antibody responses in @entity1 with @entity0 .

title: Identification of XXXX -specific antibodies in @entity1 with @entity0 vaccinated with gene-modified @entity2 cells.

answer: @entity2


abstract: Thirty HLA-A2 @entity1 with metastatic @entity0 received up to 14 vaccinations with MDA-MB-231- @entity8 , an HLA-A2 allogeneic @entity0 cell line, which had been lipofected with the cDNA for the @entity8 costimulatory molecule. @entity2 cells were administered with BCG or @entity7 as an adjuvant. Sera obtained before and after vaccination were analyzed for antibodies to @entity2 cell lysate, @entity6 , @entity4 / @entity4 and @entity3 . Since the cell line was grown in @entity5 ( @entity5 ), sera were also analyzed for antibodies to @entity5 . Eighteen of 24 @entity1 for whom sera were available exhibited anti- @entity5 activity at baseline. Eleven of these 18 @entity1 and all six @entity1 without baseline anti- @entity5 activity showed an increased titer after vaccination. The anti- @entity5 activity required that serum samples be absorbed in excess @entity5 to detect specific antibodies to @entity2 cell lysate. A two-fold increase in the titer of IgG specific to @entity2 cell lysate was observed in 6 @entity1 . Eight of 24 @entity1 made an antibody response to @entity4 , four of 24 to @entity6 and one of 24 to @entity3 . Although antibody production to a variety of @entity2 cell-associated antigens was detected our results suggest that a whole cell vaccine comprising a @entity8 -transfected allogeneic @entity0 cell line with adjuvant BCG or @entity7 was not a reliable method to induce significant antibody responses in @entity1 with @entity0 .

title: Identification of @entity2 -specific antibodies in @entity1 with @entity0 vaccinated with gene-modified XXXX cells.

answer: @entity2


abstract: Thirty HLA-A2 @entity1 with metastatic @entity0 received up to 14 vaccinations with MDA-MB-231- @entity8 , an HLA-A2 allogeneic @entity0 cell line, which had been lipofected with the cDNA for the @entity8 costimulatory molecule. @entity2 cells were administered with BCG or @entity7 as an adjuvant. Sera obtained before and after vaccination were analyzed for antibodies to @entity2 cell lysate, @entity6 , @entity4 / @entity4 and @entity3 . Since the cell line was grown in @entity5 ( @entity5 ), sera were also analyzed for antibodies to @entity5 . Eighteen of 24 @entity1 for whom sera were available exhibited anti- @entity5 activity at baseline. Eleven of these 18 @entity1 and all six @entity1 without baseline anti- @entity5 activity showed an increased titer after vaccination. The anti- @entity5 activity required that serum samples be absorbed in excess @entity5 to detect specific antibodies to @entity2 cell lysate. A two-fold increase in the titer of IgG specific to @entity2 cell lysate was observed in 6 @entity1 . Eight of 24 @entity1 made an antibody response to @entity4 , four of 24 to @entity6 and one of 24 to @entity3 . Although antibody production to a variety of @entity2 cell-associated antigens was detected our results suggest that a whole cell vaccine comprising a @entity8 -transfected allogeneic @entity0 cell line with adjuvant BCG or @entity7 was not a reliable method to induce significant antibody responses in @entity1 with @entity0 .

title: Identification of @entity2 -specific antibodies in XXXX with @entity0 vaccinated with gene-modified @entity2 cells.

answer: @entity1


abstract: BACKGROUND: Whether a previous high @entity2 (HTO) influences the long-term function or survival of a total knee arthroplasty (TKA) is controversial. QUESTIONS/PURPOSES: We compared long-term functional scores and survival of bilateral TKAs in @entity0 who had a previous HTO in one of the knees. @entity0 AND METHODS: From 1980 to 1995, we performed 5043 primary TKAs; 39 of these @entity0 had bilateral TKAs at an average of 8.7 years after unilateral HTO. Surgery was simultaneous in 32 @entity0 and staged in seven. There were 12 @entity0 and 27 @entity0 with an average age of 66.9 years at the time of surgery. At last followup, 19 of the 39 @entity0 were living and had been reevaluated since our previous study. We determined function with Knee Society scores. The length of followup for @entity0 who had HTOs averaged 14 years (range, 3-21 years); for @entity0 without HTOs, the average followup was 13.9 years (range, 3-22 years). RESULTS: We observed no differences in Knee Society function and radiographic and @entity1 scores between the knees without and with previous HTO. Terminal extension and flexion, arc of motion, and knee alignment were similar between the knees. There were no femorotibial revisions in either group of knees. Survival at 15 years was 100% for knees without previous HTO and 97% for knees with previous HTO. CONCLUSIONS: Our observations suggest a previous high @entity2 does not influence the function or survival of a knee long term. LEVEL OF EVIDENCE: Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

title: Does high XXXX affect the success or survival of a total knee replacement?

answer: @entity2


abstract: The purpose of this study was to evaluate the epidemiology of @entity3 in the Bordeaux area (Dermatology Unit of the H  pital des Enfants, Bordeaux) during a 6-year period (January, 1979 to December, 1984). @entity1 of the hair was proven by culture in 124 @entity0 , 21 of whom had a negative @entity4 direct examination. Age and sex distribution are shown in figure 1. One case was observed in a 15 days old @entity0 , and 4 cases in adult females (3 young black mothers of affected @entity0 , 1 elderly white @entity0 ). Table I indicates the geographical origin of the @entity0 and the isolates identified. The incidence of anthropophilic dermatophytes has increased from 13 p. 100 to 50 p. 100 since our previous survey (1975-1978). M. langeronii (29 cases), T. soudanense (19 cases) and T. violaceum (10 cases) were isolated mostly among African immigrants from Western tropical Africa and the Maghreb. However, 4 @entity0 of French origin without any history of previous sojourn in endemic areas developed @entity3 due to M. langeronii; the source of contamination could not be determined. Zoophilic dermatophyte infection was mainly caused by @entity5 (50 cases), with @entity2 being the most frequent source of contamination. Family cases were frequent: 64 corresponding to 28 families. This may be due to either interhuman contamination or the presence of a contact pet animal in the family. The discussion is focused on: the shift in dermatophytic isolates from @entity3 toward anthropophilic species, notably M. langeronii, mainly caused by an increased immigration from West Africa; the relevant clinical and mycological correlations.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Course of the dermatophytic spectrum in XXXX . Apropos of 124 cases seen in Bordeaux].

answer: @entity3


abstract: OBJECTIVE: The study aimed to analyze the results of the intratympanic injection of @entity4 as a treatment option for @entity0 with unilateral @entity5 who were refractory to medical treatment. STUDY DESIGN: Prospective study in the setting of a tertiary care medical center. METHODS: Seventy-one @entity0 with unilateral @entity5 according to 1995 American Academy of Otolaryngology-Head and Neck Surgery 1995 guidelines who had been unresponsive to medical therapy for at least 1 year were studied. Intratympanic injections of a prepared concentration of 27 mg/mL @entity4 were performed at weekly intervals until the development of symptoms and signs indicative of @entity3 in the treated ear. As the main outcome measure, the 1995 American Academy of Otolaryngology-Head and Neck Surgery criteria for reporting treatment outcome in @entity5 were used. The results of treatment were expressed in terms of control of vertigo, disability status (functional level and degree of overall impairment evaluated by the Dizziness Handicap Inventory and the University of California Los Angeles Dizziness Questionnaire), hearing level, and quantitative measurement of vestibular function. RESULTS: Vertigo was controlled in 83.1% of the 71 @entity0 . Recurrence of vertigo spells after initially complete control was noted in 17 @entity0 . In 13 of these @entity0 , this was cured by another course of intratympanic injections of @entity4 . Functional level and measures of self-reported handicap were significantly and promptly lowered after treatment in the @entity0 who attained control of vertigo. Hearing level as pure-tone average was unchanged 2 years after treatment, but @entity2 as a result of @entity4 injections occurred in 23 @entity0 at the end of treatment and in 9 and 11 @entity0 at 3 months and 2 years after the treatment, respectively. Vestibular function was kept normal or reduced in 49.3% of the @entity0 , whereas in the rest of the @entity0 vestibular areflexia was observed. Control of vertigo did not depend on the amount of @entity1 . CONCLUSIONS: Ending weekly intratympanic injections when clinical signs of vestibular deafferentation appear can control vertigo in the majority of @entity0 , and it is a useful alternative, together with other surgical options, for the treatment of @entity0 with @entity5 who do not respond to medical treatment.

title: Intratympanic @entity4 for intractable XXXX .

answer: @entity5


abstract: OBJECTIVE: The study aimed to analyze the results of the intratympanic injection of @entity4 as a treatment option for @entity0 with unilateral @entity5 who were refractory to medical treatment. STUDY DESIGN: Prospective study in the setting of a tertiary care medical center. METHODS: Seventy-one @entity0 with unilateral @entity5 according to 1995 American Academy of Otolaryngology-Head and Neck Surgery 1995 guidelines who had been unresponsive to medical therapy for at least 1 year were studied. Intratympanic injections of a prepared concentration of 27 mg/mL @entity4 were performed at weekly intervals until the development of symptoms and signs indicative of @entity3 in the treated ear. As the main outcome measure, the 1995 American Academy of Otolaryngology-Head and Neck Surgery criteria for reporting treatment outcome in @entity5 were used. The results of treatment were expressed in terms of control of vertigo, disability status (functional level and degree of overall impairment evaluated by the Dizziness Handicap Inventory and the University of California Los Angeles Dizziness Questionnaire), hearing level, and quantitative measurement of vestibular function. RESULTS: Vertigo was controlled in 83.1% of the 71 @entity0 . Recurrence of vertigo spells after initially complete control was noted in 17 @entity0 . In 13 of these @entity0 , this was cured by another course of intratympanic injections of @entity4 . Functional level and measures of self-reported handicap were significantly and promptly lowered after treatment in the @entity0 who attained control of vertigo. Hearing level as pure-tone average was unchanged 2 years after treatment, but @entity2 as a result of @entity4 injections occurred in 23 @entity0 at the end of treatment and in 9 and 11 @entity0 at 3 months and 2 years after the treatment, respectively. Vestibular function was kept normal or reduced in 49.3% of the @entity0 , whereas in the rest of the @entity0 vestibular areflexia was observed. Control of vertigo did not depend on the amount of @entity1 . CONCLUSIONS: Ending weekly intratympanic injections when clinical signs of vestibular deafferentation appear can control vertigo in the majority of @entity0 , and it is a useful alternative, together with other surgical options, for the treatment of @entity0 with @entity5 who do not respond to medical treatment.

title: Intratympanic XXXX for intractable @entity5 .

answer: @entity4


abstract: A two-stage extraction of isolated cell walls of @entity7 resulted in 45% solubilization into antigens of high molecular weight leaving a wall residue which also had antigenic properties. Ice-cold dilute alkali removed 25% of the defatted cell walls. The extract was nondialyzable, had a @entity2 -to- @entity6 ratio of 2:3 and an @entity3 content of 7.32%, and was designated peptidoglucomannan ( @entity9 ). An additional 26% of the walls resistant to stage I were solubilized by sonic treatment yielding a fraction having a @entity2 -to- @entity6 ratio of 6:1, termed soluble mannoglucan (sMG). The residue after extraction and sonic treatment contained 10.9% @entity6 , which was the insoluble mannoglucan. The gel permeation behavior of @entity9 and sMG on BioGel A5M was similar; each contained two components, one estimated to exceed 5 x 10(6) molecular weight and a second smaller species. The soluble cell wall fractions were active in immunodiffusion and carried antigenic group specificity. Immunoelectrophoresis of @entity9 , sMG, and mannan revealed some heterogeneity. The insoluble mannoglucan had agglutinating activity. A distinctive immunodiffusion pattern of cell wall antigens was formed with the serum of a @entity5 @entity0 with @entity8 . All three cell wall antigens and mannan elicited @entity1 as measured by skin-test and specific inhibition of macrophage migration. A dose of 25 mug of @entity9 was sufficient to inhibit 89.9% migration in the peritoneal exudates of @entity4 immunized with cell walls, and 10 mug of @entity9 inhibited 91.7% migration in @entity4 immunized with insoluble mannoglucan.

title: Serological and cellular immune activity of peptidoglucomannan fractions of XXXX cell walls.

answer: @entity7


abstract: Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging. In this study we investigated the molecular mediators of the @entity0 activity of the structurally related antiprogestins @entity5 , @entity12 and @entity11 . We studied the responses of wt @entity3 OV2008 and @entity3 null SK-OV-3 cells to varying doses of @entity5 , @entity12 and @entity11 . The @entity1 inhibited the growth of both cell lines with a potency of @entity5 > @entity12 > @entity11 , and were cytostatic at lower doses but lethal at higher concentrations. Antiprogestin-induced lethality associated with morphological features of apoptosis, hypodiploid DNA content, DNA fragmentation, and cleavage of executer caspase substrate @entity7 . Cell death ensued despite @entity5 caused transient up-regulation of anti-apoptotic @entity2 , @entity12 induced transient up-regulation of inhibitor of apoptosis @entity8 , and @entity11 up-regulated both @entity8 and @entity2 . The antiprogestins induced accumulation of Cdk inhibitors @entity4 ( @entity4 ) and @entity6 ( @entity9 ) and increased association of @entity4 ( @entity4 ) and @entity6 ( @entity9 ) with @entity10 . They also promoted nuclear localization of @entity4 ( @entity4 ) and @entity6 ( @entity9 ), reduced the nuclear abundances of @entity10 and cyclin E, and blocked the activity of @entity10 in both nucleus and cytoplasm. The cytotoxic potency of the antiprogestins correlated with the magnitude of the inhibition of @entity10 activity, ranging from G1 cell cycle arrest towards cell death. Our results suggest that, as a consequence of their cytostatic and lethal effects, antiprogestin steroids of well-known contraceptive properties emerge as attractive new agents to be repositioned for @entity0 therapeutics.

title: Growth inhibition induced by antiprogestins @entity5 , XXXX , and @entity11 in @entity0 cells involves inhibition of @entity10 .

answer: @entity12


abstract: Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging. In this study we investigated the molecular mediators of the @entity0 activity of the structurally related antiprogestins @entity5 , @entity12 and @entity11 . We studied the responses of wt @entity3 OV2008 and @entity3 null SK-OV-3 cells to varying doses of @entity5 , @entity12 and @entity11 . The @entity1 inhibited the growth of both cell lines with a potency of @entity5 > @entity12 > @entity11 , and were cytostatic at lower doses but lethal at higher concentrations. Antiprogestin-induced lethality associated with morphological features of apoptosis, hypodiploid DNA content, DNA fragmentation, and cleavage of executer caspase substrate @entity7 . Cell death ensued despite @entity5 caused transient up-regulation of anti-apoptotic @entity2 , @entity12 induced transient up-regulation of inhibitor of apoptosis @entity8 , and @entity11 up-regulated both @entity8 and @entity2 . The antiprogestins induced accumulation of Cdk inhibitors @entity4 ( @entity4 ) and @entity6 ( @entity9 ) and increased association of @entity4 ( @entity4 ) and @entity6 ( @entity9 ) with @entity10 . They also promoted nuclear localization of @entity4 ( @entity4 ) and @entity6 ( @entity9 ), reduced the nuclear abundances of @entity10 and cyclin E, and blocked the activity of @entity10 in both nucleus and cytoplasm. The cytotoxic potency of the antiprogestins correlated with the magnitude of the inhibition of @entity10 activity, ranging from G1 cell cycle arrest towards cell death. Our results suggest that, as a consequence of their cytostatic and lethal effects, antiprogestin steroids of well-known contraceptive properties emerge as attractive new agents to be repositioned for @entity0 therapeutics.

title: Growth inhibition induced by antiprogestins XXXX , @entity12 , and @entity11 in @entity0 cells involves inhibition of @entity10 .

answer: @entity5


abstract: Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging. In this study we investigated the molecular mediators of the @entity0 activity of the structurally related antiprogestins @entity5 , @entity12 and @entity11 . We studied the responses of wt @entity3 OV2008 and @entity3 null SK-OV-3 cells to varying doses of @entity5 , @entity12 and @entity11 . The @entity1 inhibited the growth of both cell lines with a potency of @entity5 > @entity12 > @entity11 , and were cytostatic at lower doses but lethal at higher concentrations. Antiprogestin-induced lethality associated with morphological features of apoptosis, hypodiploid DNA content, DNA fragmentation, and cleavage of executer caspase substrate @entity7 . Cell death ensued despite @entity5 caused transient up-regulation of anti-apoptotic @entity2 , @entity12 induced transient up-regulation of inhibitor of apoptosis @entity8 , and @entity11 up-regulated both @entity8 and @entity2 . The antiprogestins induced accumulation of Cdk inhibitors @entity4 ( @entity4 ) and @entity6 ( @entity9 ) and increased association of @entity4 ( @entity4 ) and @entity6 ( @entity9 ) with @entity10 . They also promoted nuclear localization of @entity4 ( @entity4 ) and @entity6 ( @entity9 ), reduced the nuclear abundances of @entity10 and cyclin E, and blocked the activity of @entity10 in both nucleus and cytoplasm. The cytotoxic potency of the antiprogestins correlated with the magnitude of the inhibition of @entity10 activity, ranging from G1 cell cycle arrest towards cell death. Our results suggest that, as a consequence of their cytostatic and lethal effects, antiprogestin steroids of well-known contraceptive properties emerge as attractive new agents to be repositioned for @entity0 therapeutics.

title: Growth inhibition induced by antiprogestins @entity5 , @entity12 , and @entity11 in @entity0 cells involves inhibition of XXXX .

answer: @entity10


abstract: Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging. In this study we investigated the molecular mediators of the @entity0 activity of the structurally related antiprogestins @entity5 , @entity12 and @entity11 . We studied the responses of wt @entity3 OV2008 and @entity3 null SK-OV-3 cells to varying doses of @entity5 , @entity12 and @entity11 . The @entity1 inhibited the growth of both cell lines with a potency of @entity5 > @entity12 > @entity11 , and were cytostatic at lower doses but lethal at higher concentrations. Antiprogestin-induced lethality associated with morphological features of apoptosis, hypodiploid DNA content, DNA fragmentation, and cleavage of executer caspase substrate @entity7 . Cell death ensued despite @entity5 caused transient up-regulation of anti-apoptotic @entity2 , @entity12 induced transient up-regulation of inhibitor of apoptosis @entity8 , and @entity11 up-regulated both @entity8 and @entity2 . The antiprogestins induced accumulation of Cdk inhibitors @entity4 ( @entity4 ) and @entity6 ( @entity9 ) and increased association of @entity4 ( @entity4 ) and @entity6 ( @entity9 ) with @entity10 . They also promoted nuclear localization of @entity4 ( @entity4 ) and @entity6 ( @entity9 ), reduced the nuclear abundances of @entity10 and cyclin E, and blocked the activity of @entity10 in both nucleus and cytoplasm. The cytotoxic potency of the antiprogestins correlated with the magnitude of the inhibition of @entity10 activity, ranging from G1 cell cycle arrest towards cell death. Our results suggest that, as a consequence of their cytostatic and lethal effects, antiprogestin steroids of well-known contraceptive properties emerge as attractive new agents to be repositioned for @entity0 therapeutics.

title: Growth inhibition induced by antiprogestins @entity5 , @entity12 , and XXXX in @entity0 cells involves inhibition of @entity10 .

answer: @entity11


abstract: Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging. In this study we investigated the molecular mediators of the @entity0 activity of the structurally related antiprogestins @entity5 , @entity12 and @entity11 . We studied the responses of wt @entity3 OV2008 and @entity3 null SK-OV-3 cells to varying doses of @entity5 , @entity12 and @entity11 . The @entity1 inhibited the growth of both cell lines with a potency of @entity5 > @entity12 > @entity11 , and were cytostatic at lower doses but lethal at higher concentrations. Antiprogestin-induced lethality associated with morphological features of apoptosis, hypodiploid DNA content, DNA fragmentation, and cleavage of executer caspase substrate @entity7 . Cell death ensued despite @entity5 caused transient up-regulation of anti-apoptotic @entity2 , @entity12 induced transient up-regulation of inhibitor of apoptosis @entity8 , and @entity11 up-regulated both @entity8 and @entity2 . The antiprogestins induced accumulation of Cdk inhibitors @entity4 ( @entity4 ) and @entity6 ( @entity9 ) and increased association of @entity4 ( @entity4 ) and @entity6 ( @entity9 ) with @entity10 . They also promoted nuclear localization of @entity4 ( @entity4 ) and @entity6 ( @entity9 ), reduced the nuclear abundances of @entity10 and cyclin E, and blocked the activity of @entity10 in both nucleus and cytoplasm. The cytotoxic potency of the antiprogestins correlated with the magnitude of the inhibition of @entity10 activity, ranging from G1 cell cycle arrest towards cell death. Our results suggest that, as a consequence of their cytostatic and lethal effects, antiprogestin steroids of well-known contraceptive properties emerge as attractive new agents to be repositioned for @entity0 therapeutics.

title: Growth inhibition induced by antiprogestins @entity5 , @entity12 , and @entity11 in XXXX cells involves inhibition of @entity10 .

answer: @entity0


abstract: BACKGROUND: The aim of the present study was to evaluate the clinical importance of the morphology of @entity2 invasion and its volume in early @entity4 . MATERIALS AND METHODS: The subjects were 92 @entity0 with a single lesion of early @entity4 , who underwent gastrectomy with dissection of lymph nodes, and in whom the lesion was histologically-diagnosed as early @entity4 with @entity1 . The volume of lesions (Vsm, S: < 50 mm3, L: > = 50 mm3) was determined by reconstructing @entity3 by the surface rendering method using pathological tissue sections (mean, 3.6 sections/lesion). The relationships between the volume of lesions and lymph node @entity1 and between conventional clinicopathological parameters and lymph node @entity1 were evaluated. RESULTS: Lymph node @entity1 was observed in 18 @entity0 (20%). The depth of @entity1 was 1.7 +/- 1.4 mm (mean +/- S.D.; range, 0.2-7.5 mm). @entity5 (depth of @entity2 invasion < 0.5 mm) was observed in 11 @entity0 (12%), and @entity6 (depth of @entity2 invasion > = 0.5 mm) in 81 @entity0 (88%). The mean Vsm was 104.1 +/- 215.4 mm3 (0.4-1,730.5 mm3). Fifty-seven @entity0 (62.0%) were in group S, and 35 @entity0 (38.0%) in group L. There was a significant difference between lymph node @entity1 and Vsm (S vs. L) alone (p = 0.006). Logistic regression analysis also demonstrated that Vsm alone was correlated with lymph node @entity1 (p = 0.005; odds ratio, 1.27; 95% confidence interval, 0.074-0.401). CONCLUSION: The volume of @entity3 in early @entity4 is important for evaluating lymph node @entity1 .

title: Evaluation of the morphology of @entity2 invasion and its volume in early XXXX .

answer: @entity4


abstract: BACKGROUND: The aim of the present study was to evaluate the clinical importance of the morphology of @entity2 invasion and its volume in early @entity4 . MATERIALS AND METHODS: The subjects were 92 @entity0 with a single lesion of early @entity4 , who underwent gastrectomy with dissection of lymph nodes, and in whom the lesion was histologically-diagnosed as early @entity4 with @entity1 . The volume of lesions (Vsm, S: < 50 mm3, L: > = 50 mm3) was determined by reconstructing @entity3 by the surface rendering method using pathological tissue sections (mean, 3.6 sections/lesion). The relationships between the volume of lesions and lymph node @entity1 and between conventional clinicopathological parameters and lymph node @entity1 were evaluated. RESULTS: Lymph node @entity1 was observed in 18 @entity0 (20%). The depth of @entity1 was 1.7 +/- 1.4 mm (mean +/- S.D.; range, 0.2-7.5 mm). @entity5 (depth of @entity2 invasion < 0.5 mm) was observed in 11 @entity0 (12%), and @entity6 (depth of @entity2 invasion > = 0.5 mm) in 81 @entity0 (88%). The mean Vsm was 104.1 +/- 215.4 mm3 (0.4-1,730.5 mm3). Fifty-seven @entity0 (62.0%) were in group S, and 35 @entity0 (38.0%) in group L. There was a significant difference between lymph node @entity1 and Vsm (S vs. L) alone (p = 0.006). Logistic regression analysis also demonstrated that Vsm alone was correlated with lymph node @entity1 (p = 0.005; odds ratio, 1.27; 95% confidence interval, 0.074-0.401). CONCLUSION: The volume of @entity3 in early @entity4 is important for evaluating lymph node @entity1 .

title: Evaluation of the morphology of XXXX invasion and its volume in early @entity4 .

answer: @entity2


abstract: To determine if electrocardiographic findings characterize tricyclic antidepressant ( @entity3 ) @entity2 and @entity1 , 25 @entity0 suspected of taking an @entity2 of @entity3 were studied. Toxicologic assays for a @entity3 were positive in 11 @entity0 (+ @entity3 , n = 11). Toxicologic study results for a @entity3 were negative in 14 @entity0 (- @entity3 , control subjects). @entity0 with positive @entity3 results (+ @entity3 ) had a significantly greater heart rate (117 +/- 23 vs 100 +/- 22 beats/min, p less than 0.05), QRS duration (103 +/- 15 vs 87 +/- 10 ms, p less than 0.005) and corrected QT interval (449 +/- 38 vs 418 +/- 36 ms, p less than 0.05) than control @entity0 (- @entity3 ) on admission. @entity0 with positive @entity3 results also had a more rightward terminal 40-ms frontal plane QRS vector (195 +/- 51 degrees vs 54 +/- 64 degrees, p less than 0.001) than control @entity0 . This observation has not been previously reported. A terminal QRS vector of 130 degrees to 270 degrees accurately discriminated between - @entity3 and + @entity3 @entity0 (positive and negative predictive value = 1.00). Counterclockwise rotation (normalization) of the terminal frontal plane QRS vector was noted in + @entity3 @entity0 during hospitalization. All + @entity3 @entity0 had a @entity4 , a corrected QT interval 418 ms or longer, and a terminal QRS vector between 130 degrees and 270 degrees. Using these values as selection criteria, a computer-aided search of 15,064 electrocardiograms (ECGs) recorded in our emergency department was performed. The likelihood of encountering such an electrocardiographic pattern in this population was 1.0%.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Electrocardiographic criteria for tricyclic antidepressant XXXX .

answer: @entity1


abstract: Data from a case-control study of miscarriages ( @entity2 ) were used to test whether single and multiple induced @entity3 are associated with @entity2 in subsequent euploid (chromosomally normal) pregnancies. Cases and controls were identified in three New York City hospitals between April 1974 and November 1982. It was hypothesized that, if induced abortion increased the risk of subsequent @entity2 , an association would be observed with euploid but not @entity1 (chromosomally abnormal) @entity2 . The frequencies of single and multiple induced @entity3 among euploid cases and @entity1 cases were compared with those among controls. Among both private and public @entity0 , the proportion of @entity0 reporting a single induced abortion was similar in euploid cases and in @entity1 cases compared to controls. Among public @entity0 only, the proportions reporting multiple induced @entity3 were also similar in euploid cases and in @entity1 cases compared to controls (odds ratios = 0.9 and 1.0, respectively). In contrast, among private @entity0 , the proportion reporting multiple induced @entity3 was raised among euploid cases (odds ratio = 2.2, 95% confidence interval = 1.3-3.7), although not among @entity1 cases. This association was strongest when the first induced abortion was carried out before 1973, at a young age, or with a procedure other than suction curettage. In public @entity0 , the associations with @entity2 did not vary with characteristics of the first induced abortion, but multiple induced abortion histories when the first two induced @entity3 occurred before 1973 were in excess among euploid cases compared to controls. These results suggest that, for both private and public @entity0 , neither single nor multiple induced @entity3 as now performed are likely to increase the risk of @entity2 in subsequent pregnancies. They also suggest a mechanical origin for some miscarriages.

title: Induced abortion and the chromosomal characteristics of subsequent miscarriages ( XXXX ).

answer: @entity2


abstract: We previously reported the finding of @entity7 , @entity4 , and hyperapobetalipoproteinemia (hyperapoB) in five siblings in a large Amish pedigree ascertained through a 13-year-old @entity0 who died suddenly from advanced @entity2 . Here, we present further analyses of the plasma levels of the plant @entity5 , @entity6 , of low density (beta) lipoprotein (LDL) @entity5 , and of @entity8 protein. Of 254 relatives and spouses of the proband, 90.5% were examined. A series of genetic models were explored using a pedigree analysis where parameters reflecting frequency, transmission, and penetrance of putative genotypes were examined simultaneously using a maximum likelihood approach. Segregation analysis of the @entity6 levels showed that the phenotype of @entity7 was controlled by a rare autosomal recessive gene. There was also significant familial correlation in plasma @entity6 levels that was attributed to a polygenic component under a mixed model but could also be due to shared environments such as diets. The recessive model was supported by our finding that the plasma @entity6 levels in the parents and in six @entity0 born to three of the five sitosterolemics were less than 1 mg/dl, well within the normal range. The phenotype of hyperapoB is based on an elevated level of @entity8 protein in the presence of a normal LDL @entity1 level (low LDL @entity5 to @entity8 ratio). For both LDL @entity5 and @entity8 , a polygenic model showed a slightly greater improvement in ln likelihood than did the Mendelian single locus model when both were compared to a sporadic model. Similar results were obtained for @entity5 levels of high density (alpha) lipoprotein (HDL) @entity5 . When segregation analysis was performed using the ratio of LDL @entity5 to @entity8 , the Mendelian single locus model gave a slightly better fit to the data than did the polygenic model. While the analyses presented here provided unequivocal evidence for the recessive phenotype of @entity7 , we also identified a possible single gene factor that could account for the major portion of the strong @entity3 in the ratio of LDL @entity5 to @entity8 , and to a lesser extent @entity8 . However, there is clear evidence of @entity3 for these traits in this pedigree beyond that due to Mendelian components.

title: Genetic analysis of plasma XXXX , apoprotein B, and lipoproteins in a large Amish pedigree with @entity7 .

answer: @entity6


abstract: We previously reported the finding of @entity7 , @entity4 , and hyperapobetalipoproteinemia (hyperapoB) in five siblings in a large Amish pedigree ascertained through a 13-year-old @entity0 who died suddenly from advanced @entity2 . Here, we present further analyses of the plasma levels of the plant @entity5 , @entity6 , of low density (beta) lipoprotein (LDL) @entity5 , and of @entity8 protein. Of 254 relatives and spouses of the proband, 90.5% were examined. A series of genetic models were explored using a pedigree analysis where parameters reflecting frequency, transmission, and penetrance of putative genotypes were examined simultaneously using a maximum likelihood approach. Segregation analysis of the @entity6 levels showed that the phenotype of @entity7 was controlled by a rare autosomal recessive gene. There was also significant familial correlation in plasma @entity6 levels that was attributed to a polygenic component under a mixed model but could also be due to shared environments such as diets. The recessive model was supported by our finding that the plasma @entity6 levels in the parents and in six @entity0 born to three of the five sitosterolemics were less than 1 mg/dl, well within the normal range. The phenotype of hyperapoB is based on an elevated level of @entity8 protein in the presence of a normal LDL @entity1 level (low LDL @entity5 to @entity8 ratio). For both LDL @entity5 and @entity8 , a polygenic model showed a slightly greater improvement in ln likelihood than did the Mendelian single locus model when both were compared to a sporadic model. Similar results were obtained for @entity5 levels of high density (alpha) lipoprotein (HDL) @entity5 . When segregation analysis was performed using the ratio of LDL @entity5 to @entity8 , the Mendelian single locus model gave a slightly better fit to the data than did the polygenic model. While the analyses presented here provided unequivocal evidence for the recessive phenotype of @entity7 , we also identified a possible single gene factor that could account for the major portion of the strong @entity3 in the ratio of LDL @entity5 to @entity8 , and to a lesser extent @entity8 . However, there is clear evidence of @entity3 for these traits in this pedigree beyond that due to Mendelian components.

title: Genetic analysis of plasma @entity6 , apoprotein B, and lipoproteins in a large Amish pedigree with XXXX .

answer: @entity7


abstract: @entity4 are the leading cause of @entity3 . Determination of the substrates conducive to the initiation of @entity4 remains an important clinical goal. The purpose of this study was to correlate electrophysiologic and histopathologic parameters conducive to the initiation of sustained @entity4 using programmed electrical stimulation in two @entity0 models of @entity2 . Histopathologic correlates included: @entity5 pattern (heterogeneous vs. homogeneous morphology), distribution (viable epicardial or endocardial rim), and size. Twenty-one adult @entity0 were randomly divided into two groups: (1) 12 @entity0 underwent two-stage, 2-hour occlusion of the proximal @entity1 ( @entity6 ); and (2) nine animals had permanent, complete occlusion of the @entity6 with latex embolization. Using programmed ventricular pacing with two premature ventricular extrastimuli, initiation of @entity4 was attempted at both 1 and 2 weeks after @entity5 with the chest closed and opened each time. Electrophysiologic evaluation of the @entity5 type correlated significantly with the histologic morphology of the @entity5 (p less than 0.001), the presence of a viable epicardial rim was an extremely important discriminating variable for ability to induce sustained @entity4 (p = 0.04). The presence of an endocardial rim was not significant (p = 1.0). @entity5 size alone was only marginally related to @entity4 inducibility (p = 0.08). Non-uniform @entity5 were more conducive to the initiation of sustained @entity4 (p = 0.025). The presence of a large, non-uniform @entity5 was the best overall discrimination variable for inducibility (p = 0.0002). Thus, in these experimental models, specific @entity5 correlate significantly with susceptibility to inducible sustained @entity4 .

title: Histopathologic correlates of inducible XXXX in two experimental @entity0 models of @entity2 .

answer: @entity4


abstract: @entity4 are the leading cause of @entity3 . Determination of the substrates conducive to the initiation of @entity4 remains an important clinical goal. The purpose of this study was to correlate electrophysiologic and histopathologic parameters conducive to the initiation of sustained @entity4 using programmed electrical stimulation in two @entity0 models of @entity2 . Histopathologic correlates included: @entity5 pattern (heterogeneous vs. homogeneous morphology), distribution (viable epicardial or endocardial rim), and size. Twenty-one adult @entity0 were randomly divided into two groups: (1) 12 @entity0 underwent two-stage, 2-hour occlusion of the proximal @entity1 ( @entity6 ); and (2) nine animals had permanent, complete occlusion of the @entity6 with latex embolization. Using programmed ventricular pacing with two premature ventricular extrastimuli, initiation of @entity4 was attempted at both 1 and 2 weeks after @entity5 with the chest closed and opened each time. Electrophysiologic evaluation of the @entity5 type correlated significantly with the histologic morphology of the @entity5 (p less than 0.001), the presence of a viable epicardial rim was an extremely important discriminating variable for ability to induce sustained @entity4 (p = 0.04). The presence of an endocardial rim was not significant (p = 1.0). @entity5 size alone was only marginally related to @entity4 inducibility (p = 0.08). Non-uniform @entity5 were more conducive to the initiation of sustained @entity4 (p = 0.025). The presence of a large, non-uniform @entity5 was the best overall discrimination variable for inducibility (p = 0.0002). Thus, in these experimental models, specific @entity5 correlate significantly with susceptibility to inducible sustained @entity4 .

title: Histopathologic correlates of inducible @entity4 in two experimental @entity0 models of XXXX .

answer: @entity2


abstract: @entity4 are the leading cause of @entity3 . Determination of the substrates conducive to the initiation of @entity4 remains an important clinical goal. The purpose of this study was to correlate electrophysiologic and histopathologic parameters conducive to the initiation of sustained @entity4 using programmed electrical stimulation in two @entity0 models of @entity2 . Histopathologic correlates included: @entity5 pattern (heterogeneous vs. homogeneous morphology), distribution (viable epicardial or endocardial rim), and size. Twenty-one adult @entity0 were randomly divided into two groups: (1) 12 @entity0 underwent two-stage, 2-hour occlusion of the proximal @entity1 ( @entity6 ); and (2) nine animals had permanent, complete occlusion of the @entity6 with latex embolization. Using programmed ventricular pacing with two premature ventricular extrastimuli, initiation of @entity4 was attempted at both 1 and 2 weeks after @entity5 with the chest closed and opened each time. Electrophysiologic evaluation of the @entity5 type correlated significantly with the histologic morphology of the @entity5 (p less than 0.001), the presence of a viable epicardial rim was an extremely important discriminating variable for ability to induce sustained @entity4 (p = 0.04). The presence of an endocardial rim was not significant (p = 1.0). @entity5 size alone was only marginally related to @entity4 inducibility (p = 0.08). Non-uniform @entity5 were more conducive to the initiation of sustained @entity4 (p = 0.025). The presence of a large, non-uniform @entity5 was the best overall discrimination variable for inducibility (p = 0.0002). Thus, in these experimental models, specific @entity5 correlate significantly with susceptibility to inducible sustained @entity4 .

title: Histopathologic correlates of inducible @entity4 in two experimental XXXX models of @entity2 .

answer: @entity0


abstract: Chesley's classic long-term follow up study of eclamptic @entity0 clearly demonstrated the prognostic significance of parity in the differential diagnosis of various @entity2 diseases of pregnancy. Multiparous @entity0 with @entity3 were different on long-term follow-up from primiparous eclamptic @entity0 . A logical conclusion from this observation is that multiparous and primiparous @entity0 groups should be analyzed separately whenever @entity2 diseases of pregnancy are evaluated. This study is therefore an attempt to define the clinical profile of @entity2 during pregnancy on the basis of parity alone. The prenatal and hospital records of 99 successive pregnant @entity0 identified as @entity2 during a 1-year period at Mount Sinai Hospital Medical Center served as the study population. A group of 25 primiparous and 25 multiparous @entity0 , all with uncomplicated pregnancies and normal deliveries in sequence during a 1-month period, served as normal nonhypertensive control groups. Various pregnancy parameters were statistically evaluated for study and control groups. Significant differences were found between @entity2 primiparous and multiparous @entity0 in mean weight increase (p less than 0.05), gestational age at first increase in blood pressure (p less than 0.007), and time from first increase in blood pressure until delivery (p less than 0.008). The difference in birth weight was not significant between @entity2 groups. In contrast, among the control groups, multiparous @entity0 had significantly larger offspring than primiparous @entity0 (p less than 0.01). Weights of normal primiparous control @entity0 were almost identical to those of primiparous @entity2 @entity0 (3252.8 +/- 511.8 versus 3203.26 +/- 679.5 gm). Birth weights of offspring from multiparous @entity2 @entity0 , while not significantly different from those of primiparous @entity2 @entity0 , were significantly lower than those of multiparous control subjects (3093.94 +/- 898.7 versus 3593 +/- 305.6; p less than 0.01). No significant differences in a variety of laboratory findings, reflexes, @entity1 , or mode of delivery were observed between the various groups. The clinical and laboratory presentation of @entity2 in pregnancy may be similar between primiparous and multiparous @entity0 . Nevertheless, clear differences do exist in both maternal presentation and impact of maternal disease on fetal growth and development. These differences strongly suggest a different pathophysiology as the underlying cause of @entity2 in primiparous and multiparous pregnant @entity0 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: XXXX diseases of pregnancy and parity.

answer: @entity2


abstract: Several vasoactive substances influence glomerular function in vivo and alter glomerular surface area and @entity6 (PG) synthesis in vitro. @entity7 (LT) LTC4 and LTD4 may also influence glomerular function in vivo and in the isolated perfused kidney. We therefore compared the effects of LT with those of @entity4 ( @entity4 ), @entity8 ( @entity5 ), and platelet activating factor (PAF) on planar surface area of isolated @entity0 glomeruli and the shape change of cultured mesangial cells and their PG synthesis. @entity4 , AVP, and PAF decreased the surface area of isolated @entity0 glomeruli by 10-14% with comparable changes induced by LTC4 and LTD4. Half-maximal effects of LTs were observed at approximately 10(-7) M. Incubation of cultured @entity0 mesangial cells with LTC4 or LTD4 at 10(-7) and 10(-8) M was also associated with shape changes of the cells resulting in significant reductions in planar surface area in a dose- and time-dependent fashion similar to that noted previously with other vasoactive agents. In cells grown on a flexible @entity1 rubber support, LTD4 resulted in rapid increases in wrinkling of the mobile surface indicating that the shape change may represent cell contraction. The LT-mediated decrease in surface area of glomeruli and mesangial cells was partially antagonized by the LT inhibitor @entity3 . In contrast to the 11- and 7-fold enhancement of @entity2 synthesis in cultured mesangial cells by @entity4 or PAF, neither LTC4 nor LTD4 affected @entity2 production. These results demonstrate that LTC4 and LTD4 cause mesangial shape changes that in the whole glomerulus may decrease glomerular surface area.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of XXXX on isolated @entity0 glomeruli and cultured mesangial cells.

answer: @entity7


abstract: Several vasoactive substances influence glomerular function in vivo and alter glomerular surface area and @entity6 (PG) synthesis in vitro. @entity7 (LT) LTC4 and LTD4 may also influence glomerular function in vivo and in the isolated perfused kidney. We therefore compared the effects of LT with those of @entity4 ( @entity4 ), @entity8 ( @entity5 ), and platelet activating factor (PAF) on planar surface area of isolated @entity0 glomeruli and the shape change of cultured mesangial cells and their PG synthesis. @entity4 , AVP, and PAF decreased the surface area of isolated @entity0 glomeruli by 10-14% with comparable changes induced by LTC4 and LTD4. Half-maximal effects of LTs were observed at approximately 10(-7) M. Incubation of cultured @entity0 mesangial cells with LTC4 or LTD4 at 10(-7) and 10(-8) M was also associated with shape changes of the cells resulting in significant reductions in planar surface area in a dose- and time-dependent fashion similar to that noted previously with other vasoactive agents. In cells grown on a flexible @entity1 rubber support, LTD4 resulted in rapid increases in wrinkling of the mobile surface indicating that the shape change may represent cell contraction. The LT-mediated decrease in surface area of glomeruli and mesangial cells was partially antagonized by the LT inhibitor @entity3 . In contrast to the 11- and 7-fold enhancement of @entity2 synthesis in cultured mesangial cells by @entity4 or PAF, neither LTC4 nor LTD4 affected @entity2 production. These results demonstrate that LTC4 and LTD4 cause mesangial shape changes that in the whole glomerulus may decrease glomerular surface area.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of @entity7 on isolated XXXX glomeruli and cultured mesangial cells.

answer: @entity0


abstract: OBJECTIVE: The origin of the mesenchymal cells responsible for the intimal @entity1 in @entity4 ( @entity4 ) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through transdifferentiation of endothelial cells (ECs) into myofibroblasts via endothelial-mesenchymal transition (EndoMT) in vitro and to explore the signaling pathways involved in this process. METHODS: Primary @entity0 pulmonary ECs isolated by immunomagnetic methods with sequential anti- @entity10 and anti- @entity12 antibody selection were cultured in monolayers. Cell morphology and diacetylated low-density lipoprotein uptake assays confirmed their EC characteristics. The induction of EndoMT was assessed by determination of a-smooth muscle actin ( @entity6 ), type I collagen, and @entity7 expression, and the expression of the transcriptional repressor @entity11 was analyzed. The signaling pathways involved were examined using small-molecule kinase inhibitors and RNA interference. RESULTS: @entity2 ( @entity2 ) induced @entity6 and type I collagen expression and inhibited @entity7 . These effects were mediated by a marked increase in @entity11 expression and were abolished by treatment with either the @entity9 @entity3 kinase inhibitor @entity5 or the protein kinase C   (PKC  ) inhibitor @entity8 . The inhibitory effects of @entity5 and @entity8 were mediated by inhibition of phosphorylation of glycogen synthase kinase 3b at residue Ser(9). These observations were confirmed in experiments using small interfering RNA specific for @entity9 and PKC  . CONCLUSION: These results indicate that @entity9 and PKC   are crucial for @entity2 -induced EndoMT and that @entity5 and @entity8 or similar kinase inhibitor molecules may be effective therapeutic agents for @entity4 and other fibroproliferative vasculopathies in which EndoMT plays a pathogenetic role.

title: XXXX kinase are required for transforming growth factor b induction of endothelial-mesenchymal transition in vitro.

answer: @entity9


abstract: BACKGROUND: The authors investigated long-term @entity1 control and @entity2 outcomes after high-dose, intensity-modulated radiation therapy (IMRT) in @entity0 who had clinically @entity3 . METHODS: Between April 1996 and January 1998, 170 @entity0 received 81 gray (Gy) using a 5-field IMRT technique. @entity0 were classified according to the National @entity1 Network-defined risk groups. @entity2 data were scored according to the Common Terminology Criteria for Adverse Events Version 3.0. Freedom from biochemical relapse, distant metastases, and cause-specific survival outcomes were calculated. The median follow-up was 99 months. RESULTS: The 10-year actuarial @entity4 relapse-free survival rates were 81% for the low-risk group, 78% for the intermediate-risk group, and 62% for the high-risk group; the 10-year distant metastases-free rates were 100%, 94%, and 90%, respectively; and the 10-year cause-specific mortality rates were 0%, 3%, and 14%, respectively. The 10-year likelihood of developing grade 2 and 3 late genitourinary @entity2 was 11% and 5%, respectively; and the 10-year likelihood of developing grade 2 and 3 late gastrointestinal @entity2 was 2% and 1%, respectively. No grade 4 @entity2 were observed. CONCLUSIONS: To the authors' knowledge, this report represents the longest followed cohort of @entity0 who received high-dose radiation levels of 81 Gy using IMRT for @entity3 . The findings indicated that high-dose IMRT is well tolerated and is associated with excellent long-term @entity1 -control outcomes in @entity0 with @entity3 .

title: Ten-year outcomes of high-dose, intensity-modulated radiotherapy for XXXX .

answer: @entity3


abstract: BACKGROUND: An individual's psychological adjustment to illness is influenced by disease severity, @entity4 , and coping strategies. A more precise understanding of the contribution of each of these factors to a @entity0 's well-being may influence the kind of psychological support required by @entity0 . This study therefore aimed to characterize the contributors to psychological well-being in @entity0 with @entity2 ( @entity2 ). The design was a cross-sectional questionnaire-based study. METHODS: Ninety-six @entity2 @entity0 (34 males, 62 females, mean age 38 years) attending a @entity1 outpatient clinic were studied. Disease severity was evaluated according to the @entity2 Activity Index (CDAI), coping styles assessed with the Carver Brief @entity6 scale, @entity4 explored with the Brief Illness Perceptions Questionnaire (BIPQ), and @entity3 and @entity5 measured using the Hospital Anxiety and @entity5 Scale (HADS). RESULTS: Combining the questionnaire data using structural equation modeling resulted in a final model with an excellent fit (  (2) (7) = 10.42, P = 0.17,   (2) /N = 1.49, root mean square error of approximation (RMSEA) < 0.07, comparative fit index (CFI) > 0.97, Goodness-of-fit index (GFI) > 0.97). Disease activity had a significant direct influence on @entity4 (b = 51, P < 0.001). In turn, @entity4 had a significant direct influence on @entity5 and @entity3 (b = 41, P < 0.001, b = 0.40, P < 0.001, respectively). Use of emotional coping strategies was associated significantly (P < 0.001) with the presence of @entity3 and @entity5 . CONCLUSIONS: There is an interrelationship between disease activity, @entity4 , coping strategies, and @entity5 and @entity3 . These aspects of psychological processing provide a framework and direction for the psychological support that @entity0 with @entity2 require.

title: Preliminary examination of the relations between disease activity, XXXX , coping strategies, and psychological morbidity in @entity2 guided by the common sense model of illness.

answer: @entity4


abstract: BACKGROUND: An individual's psychological adjustment to illness is influenced by disease severity, @entity4 , and coping strategies. A more precise understanding of the contribution of each of these factors to a @entity0 's well-being may influence the kind of psychological support required by @entity0 . This study therefore aimed to characterize the contributors to psychological well-being in @entity0 with @entity2 ( @entity2 ). The design was a cross-sectional questionnaire-based study. METHODS: Ninety-six @entity2 @entity0 (34 males, 62 females, mean age 38 years) attending a @entity1 outpatient clinic were studied. Disease severity was evaluated according to the @entity2 Activity Index (CDAI), coping styles assessed with the Carver Brief @entity6 scale, @entity4 explored with the Brief Illness Perceptions Questionnaire (BIPQ), and @entity3 and @entity5 measured using the Hospital Anxiety and @entity5 Scale (HADS). RESULTS: Combining the questionnaire data using structural equation modeling resulted in a final model with an excellent fit (  (2) (7) = 10.42, P = 0.17,   (2) /N = 1.49, root mean square error of approximation (RMSEA) < 0.07, comparative fit index (CFI) > 0.97, Goodness-of-fit index (GFI) > 0.97). Disease activity had a significant direct influence on @entity4 (b = 51, P < 0.001). In turn, @entity4 had a significant direct influence on @entity5 and @entity3 (b = 41, P < 0.001, b = 0.40, P < 0.001, respectively). Use of emotional coping strategies was associated significantly (P < 0.001) with the presence of @entity3 and @entity5 . CONCLUSIONS: There is an interrelationship between disease activity, @entity4 , coping strategies, and @entity5 and @entity3 . These aspects of psychological processing provide a framework and direction for the psychological support that @entity0 with @entity2 require.

title: Preliminary examination of the relations between disease activity, @entity4 , coping strategies, and psychological morbidity in XXXX guided by the common sense model of illness.

answer: @entity2


abstract: AIM: To investigate the effects of a probiotic formulation, VSL#3, on gastrointestinal transit and symptoms of @entity0 with @entity3 with predominant @entity1 . METHODS: Twenty-five @entity0 with @entity1 -predominant @entity3 were randomly assigned to receive VSL#3 powder (450 billion lyophilized bacteria/day) or matching placebo twice daily for 8 weeks after a 2-week run-in period. Pre- and post-treatment gastrointestinal transit measurements were performed in all @entity0 . @entity0 recorded their bowel function and symptoms daily in a diary during the 10-week study, which was powered to detect a 50% change in the primary colonic transit end-point. RESULTS: There were no significant differences in mean gastrointestinal transit measurements, bowel function scores or satisfactory global symptom relief between the two treatment groups, pre- or post-therapy. Differences in abdominal bloating scores between treatments were borderline significant (P = 0.09, analysis of covariance). Further analysis revealed that abdominal bloating was reduced (P = 0.046) with VSL#3 [mean post- minus pre-treatment score, - 13.7; 95% confidence interval (CI), - 2.5 to - 24.9], but not with placebo (P = 0.54) (mean post- minus pre-treatment score, - 1.7; 95% CI, 7.1 to - 10.4). With the exception of changes in abdominal bloating, VSL#3 had no effect on other individual symptoms: @entity2 , gas and urgency. All @entity0 tolerated VSL#3 well. CONCLUSION: VSL#3 appears to be promising in the relief of abdominal bloating in @entity0 with @entity1 -predominant @entity3 . This is unrelated to an alteration in gastrointestinal or colonic transit.

title: A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in XXXX -predominant @entity3 .

answer: @entity1


abstract: AIM: To investigate the effects of a probiotic formulation, VSL#3, on gastrointestinal transit and symptoms of @entity0 with @entity3 with predominant @entity1 . METHODS: Twenty-five @entity0 with @entity1 -predominant @entity3 were randomly assigned to receive VSL#3 powder (450 billion lyophilized bacteria/day) or matching placebo twice daily for 8 weeks after a 2-week run-in period. Pre- and post-treatment gastrointestinal transit measurements were performed in all @entity0 . @entity0 recorded their bowel function and symptoms daily in a diary during the 10-week study, which was powered to detect a 50% change in the primary colonic transit end-point. RESULTS: There were no significant differences in mean gastrointestinal transit measurements, bowel function scores or satisfactory global symptom relief between the two treatment groups, pre- or post-therapy. Differences in abdominal bloating scores between treatments were borderline significant (P = 0.09, analysis of covariance). Further analysis revealed that abdominal bloating was reduced (P = 0.046) with VSL#3 [mean post- minus pre-treatment score, - 13.7; 95% confidence interval (CI), - 2.5 to - 24.9], but not with placebo (P = 0.54) (mean post- minus pre-treatment score, - 1.7; 95% CI, 7.1 to - 10.4). With the exception of changes in abdominal bloating, VSL#3 had no effect on other individual symptoms: @entity2 , gas and urgency. All @entity0 tolerated VSL#3 well. CONCLUSION: VSL#3 appears to be promising in the relief of abdominal bloating in @entity0 with @entity1 -predominant @entity3 . This is unrelated to an alteration in gastrointestinal or colonic transit.

title: A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in @entity1 -predominant XXXX .

answer: @entity3


abstract: OBJECTIVE: To document the effectiveness and vicissitudes of treating 14 @entity1 @entity0 with @entity4 over a combined 300 years, and an average of 21 years/ @entity0 . METHODS: Chart review of the narrative and laboratory studies of these 14 @entity0 ranging in duration from 12 to 29 years. RESULTS: @entity3 stabilized these @entity1 @entity0 over these periods. Only three @entity0 required hospitalization, one because @entity3 was slowly tapered at her request after 6 years of mood stability, another because of non-compliance, and a third because of co-morbid alcohol abuse. One @entity0 attempted suicide after @entity3 was tapered off. However, in some @entity0 , there were serious side-effects necessitating @entity3 discontinuation. CONCLUSIONS: Controlled studies in psychopharmacology are obviously preferred to open-label or naturalistic case studies. However, controlled studies are rarely conducted over long periods, and practice-related naturalistic research can be of value, albeit anecdotal and without the use of structured rating scales. In this paper, we are reporting on 14 @entity0 seen consistently by one psychiatrist. These @entity0 were functional and productive at work and in family life. The @entity0 suffered brief hypomanic or @entity2 episodes. Although several @entity0 experienced serious side-effects, @entity3 was continued with stable mood, while the side-effects were managed in collaboration with other specialists.

title: Long-term therapy with XXXX in a private practice clinic: a naturalistic study.

answer: @entity3


abstract: A survey of 100 consecutive endoscopies on elderly @entity0 with suspected obstructive @entity3 is reported. Seventy-eight @entity0 had positive findings and one to three lesions were reported in these cases. Benign stricture of the oesophagus was the commonest finding, and led to active treatment (dilation) in most cases either with Hurst bougies or Eder dilators. Fifteen @entity0 had @entity1 (12 oesophagus, three stomach). All of those with @entity2 received some form of active treatment, either in the form of radiotherapy, surgery, dilation or Celestin tube insertion. Six @entity0 with negative endoscopies had diagnoses established by other means and in 14 no cause was identified, but in four of these symptoms settled after endoscopy. The duration of @entity3 was not particularly helpful clinically. Two thirds of 'endoscopically normal' @entity0 had short histories with @entity3 for less than 1 year, as did half of the @entity0 with benign stricture. Most @entity0 who were found to be malignant had experienced @entity3 for only a short time although one @entity0 had a 4-year history! Upper gastro-intestinal endoscopy is a safe and valuable procedure in elderly @entity0 with @entity3 and often leads to positive therapeutic intervention even in quite frail subjects.

title: Endoscopic evaluation of XXXX in the elderly.

answer: @entity3


abstract: PURPOSE: @entity2 of the orbit is often unilateral and solitary. Multiple @entity2 of the orbit are extremely rare. The authors reported four @entity0 who had more than two @entity2 in one orbit. METHODS: Case reports.The clinical features, imaging findings, differential diagnosis and surgical management were presented. RESULTS: We found 4 cases of multiple @entity2 of the orbit out of 214 records of all @entity0 with orbital @entity2 who were referred to us from Jan 1,1986 to Dec 31,2000. Two @entity0 were female and two were male. The mean age was 46.5 years, ranging from 37.0 to 57.0 years. The left orbits were affected in all @entity0 , with two, three, eight and ten @entity1 respectively. The most common complaint was a painless, gradually progressive proptosis. The characteristic CT imaging features were multiple well circumscribed, round or ovoid masses that were sharply delineated from the surrounding tissue. B-scan ultrasonography showed round-shaped orbital masses with high internal reflectivity. The therapeutic outcomes of lateral or anterior orbitotomy were excellent. CONCLUSION: Although rare, cavernous @entity3 should be considered in the differential diagnosis of @entity0 with multiple orbital mass lesions.

title: Multiple XXXX of the orbit.

answer: @entity2


abstract: OBJECTIVES: To examine the effect of a more-efficient home care protocol to manage @entity1 ( @entity1 ) @entity0 after surgery. DESIGN: A randomized trial of two home care protocols for @entity1 management. SETTING: A hospital-affiliated home healthcare agency in a large midwestern city. @entity0 : Medicare-eligible individuals undergoing elective total hip or knee replacement surgery (N = 136). INTERVENTION: A home care protocol that included preoperative home visits by a nurse and a physical therapist and fewer postoperative visits (range of 9-12 visits) to the home than an existing protocol (range of 11-47 visits). MEASUREMENTS: Functional status, lower extremity functioning, health-related quality of life, satisfaction with care, and use and cost of healthcare services for 6 months postsurgery. RESULTS: There were no differences in functional status, health-related quality of life, or lower extremity functioning by group at 6 months. A marginally significant gain in satisfaction with access to care (P =.059) was found in the intervention group at 6 months. Home healthcare costs were 55% lower for the streamlined group (P <.001). Other costs did not differ significantly by group. CONCLUSION: @entity1 @entity0 who received the more-efficient home care protocol experienced comparable outcomes to those who received the existing protocol. An abbreviated set of home care visits resulted in more-efficient delivery of care without compromising @entity0 outcomes.

title: Comparison of two home care protocols for XXXX .

answer: @entity1


abstract: The aim of this study was to evaluate the biologic outcome of @entity4 as compared to clinical and pathologic parameters and to identify multivariate independent prognostic factors. Charts were abstracted from @entity0 with @entity4 from 1985 to 1995. Data on clinicopathologic variables, adjuvant treatment, site of recurrence, and survival were collected. chi2 test was used to test association between variables. Kaplan-Maier method was used for survival analysis and Cox proportional hazards model for multiple regression analysis. Univariate analysis revealed that FIGO stage, @entity2 grade, depth of @entity1 , biochemical analysis of @entity5 receptor status, age, additional @entity3 , @entity6 , and type of @entity2 were significantly associated with the overall-survival. For disease-free interval, FIGO stage, @entity2 grade, depth of @entity1 , biochemical analysis of @entity5 receptor status, @entity6 , and type of @entity2 were also significantly associated. Multivariate analysis revealed that FIGO stage, @entity2 grading, @entity2 type, depth of @entity1 , and biochemically measured @entity5 receptor status were associated significantly with overall survival. A significant correlation as independent prognostic factors were also seen for recurrence free interval for FIGO stage, @entity2 grade, and biochemical @entity5 receptor status. In multivariate statistical analysis we identified FIGO stage, @entity2 type, @entity2 grade, biochemical analysis of @entity5 receptor status, and depth of @entity1 as independent prognostic factors for overall survival, and FIGO stage, biochemical analysis of @entity5 receptor status, and @entity2 grade as independent prognostic factors for recurrence-free interval.

title: Multivariate independent prognostic factors in XXXX : a clinicopathologic study in 181 @entity0 : 10 years experience at the Department of Obstetrics and Gynecology of the Mainz University.

answer: @entity4


abstract: The aim of this study was to evaluate the biologic outcome of @entity4 as compared to clinical and pathologic parameters and to identify multivariate independent prognostic factors. Charts were abstracted from @entity0 with @entity4 from 1985 to 1995. Data on clinicopathologic variables, adjuvant treatment, site of recurrence, and survival were collected. chi2 test was used to test association between variables. Kaplan-Maier method was used for survival analysis and Cox proportional hazards model for multiple regression analysis. Univariate analysis revealed that FIGO stage, @entity2 grade, depth of @entity1 , biochemical analysis of @entity5 receptor status, age, additional @entity3 , @entity6 , and type of @entity2 were significantly associated with the overall-survival. For disease-free interval, FIGO stage, @entity2 grade, depth of @entity1 , biochemical analysis of @entity5 receptor status, @entity6 , and type of @entity2 were also significantly associated. Multivariate analysis revealed that FIGO stage, @entity2 grading, @entity2 type, depth of @entity1 , and biochemically measured @entity5 receptor status were associated significantly with overall survival. A significant correlation as independent prognostic factors were also seen for recurrence free interval for FIGO stage, @entity2 grade, and biochemical @entity5 receptor status. In multivariate statistical analysis we identified FIGO stage, @entity2 type, @entity2 grade, biochemical analysis of @entity5 receptor status, and depth of @entity1 as independent prognostic factors for overall survival, and FIGO stage, biochemical analysis of @entity5 receptor status, and @entity2 grade as independent prognostic factors for recurrence-free interval.

title: Multivariate independent prognostic factors in @entity4 : a clinicopathologic study in 181 XXXX : 10 years experience at the Department of Obstetrics and Gynecology of the Mainz University.

answer: @entity0


abstract: Uterine @entity3 (USC) has a propensity for extrauterine spread, and some suggest that this disease be staged as an @entity2 , and thus include omental sampling. However, given the primary organ involved, the staging recommendations do not include omental sampling. The aim of this study is to evaluate the role of omental sampling during the surgical staging of USC. We retrospectively identified cases of USC at our institution from January 1990 to June 2000 and abstracted surgical procedures, stage, and sites of @entity1 . Fisher's exact test was used to calculate sensitivity, specificity, and positive and negative predictive value. We identified 65 @entity0 with USC, of which 52 underwent omental evaluation. Thirty four of the omentums were visually normal and benign on histologic review. Two were visually negative and histologically positive for metastatic @entity3 . The remaining 16 specimens were grossly involved with histologic confirmation of disease. The sensitivity of a visually negative omentum is 0.89 (P < 0.0001). Microscopic omental @entity1 from USC is rare. When the omentum is involved, thereby upstaging the @entity0 to stage IVB disease, the disease is generally diagnosed by gross visualization. We conclude that omental sampling does not need to be included in the routine surgical staging of USC.

title: The role of omentectomy during the surgical staging of uterine XXXX .

answer: @entity3


abstract: Catheter ablation of cardiac tissue by means of direct-current electrical energy is associated with several complications. We assessed the efficacy and safety of closed-chest catheter desiccation of the left ventricular myocardium with microbipolar radiofrequency (RF) energy (750 kHz) in five @entity1 . The unipolar configuration was used with RF energy delivered between the tip electrode of a standard No. 7F tripolar catheter in the left ventricle and an external patch electrode on the left lateral chest wall. A single application with different RF energy settings (100 J, 200 J, and 300 J) was delivered to three individual endocardial sites of the left ventricle. @entity2 or fibrillation was not observed during energy application and 24 hours after ablation, as assessed by a Holter recording. There was no damage to the electrode catheter. @entity1 were killed on the fifth day. Pathology showed well-delineated ovoid or round-shaped coagulation @entity0 at the ablation sites. Microscopic findings consisted of circumscribed areas of @entity0 surrounded by a zone of fibroblastic and mononuclear proliferation. In conclusion, catheter ablation of the ventricular myocardium with RF energy is an apparently safe procedure and can effectively produce discrete areas of injury without destruction of surrounding uninvolved myocardium. This method offers potential clinical utility for catheter ablation of refractory sustained @entity2 .

title: Transcatheter desiccation of the XXXX left ventricle using radiofrequency energy: a pilot study.

answer: @entity1


abstract: OBJECTIVE: Invasive @entity1 involving the cavernous sinus, such as recurrent @entity8 or @entity2 , raise therapeutic problems that may be resolved by @entity10 ( @entity10 ). METHODS: Our series comprises 18 @entity0 (9 @entity0 and 9 @entity0 ranging in age from 14 to 64 yr) who underwent @entity10 during the past 8 years. The @entity1 in these @entity0 included 12 @entity8 , 3 @entity4 , 1 @entity7 , 1 lipomyosarcoma, and 1 @entity6 . @entity3 was confirmed in 15 cases by a balloon occlusion test. Three @entity0 had a negative balloon occlusion test, and their internal carotid arteries were preserved (n = 1) or revascularized (n = 2) through an external carotid artery-to-middle cerebral artery bypass. RESULTS: @entity10 was performed as a primary treatment in 5 @entity0 and after one to five recurrences in 13 @entity0 . In all @entity0 , @entity10 included the internal carotid artery and Cranial Nerves III, IV, and VI and one to three branches of Cranial Nerve V. Orbital exenteration was performed in eight @entity0 , and partial hypophysectomy was performed in five @entity0 . Ten @entity0 had received radiotherapy before @entity10 , and five @entity0 underwent irradiation after @entity10 . The operative mortality includes two @entity0 . @entity9 was the main complication in four @entity0 , with three @entity0 having @entity5 . Follow-up ranged from 6 months to 5 years, with three deaths from new recurrences at 2, 3, and 4 years after @entity10 . As compared with their clinical courses before @entity10 , all @entity0 except the two who died postoperatively benefited from @entity10 . CONCLUSION: @entity10 has useful indications in invasive and rapidly growing @entity1 , including apparently @entity8 . A better understanding of the biological behavior of these @entity1 is necessary for appropriate selection of @entity0 for @entity10 .

title: Cavernous sinus exenteration for invasive XXXX .

answer: @entity1


abstract: OBJECTIVE: Recent neurosurgical literature reflects rapidly evolving, technically enhanced methods that promise to improve neurosurgical outcomes. We review our experience with computer image guidance, linear or sigmoid incisions after minimal shaving, and liquid wound dressing with @entity2 (Dermabond; Ethicon, Inc., Somerville, NJ) for @entity1 craniotomy or craniectomy in our attempt to optimize craniotomy or craniectomy for @entity1 . METHODS: After institutional review board approval, we retrospectively reviewed @entity0 who underwent craniotomy or craniectomy for @entity1 with or without the combination of techniques specified above. A prior cohort of @entity0 who underwent craniotomy or craniectomy with traditional techniques served as a retrospective basis of comparison. Analysis included in- and outpatient chart reviews, which included the operative notes, pathology reports, discharge summaries, outpatient office records, and intraoperative nursing records. Data were entered into a statistical spreadsheet for analysis and comparison. RESULTS: A total of 225 consecutive @entity0 underwent a combination of less invasive techniques from July 2000 through October 2001. These @entity0 were matched with 225 @entity0 in a standard neurosurgical cohort that included @entity0 who underwent operations from July 1994 through July 2000. Age, @entity1 type, radiation, reoperation rate, @entity1 location, and extent of resection were comparable for both groups. The overall wound complication rate was significantly lower in the minimally invasive group when compared with the control cohort of @entity0 (0.9% versus 6.2%; P = 0.0298), even for early follow-up (0.9% versus 3.5%; P = 0.0427). Pedicle flap design was a variable that was significantly associated with wound complication. CONCLUSION: Modern neurosurgical techniques are beneficial for @entity0 undergoing craniotomy or craniectomy for @entity1 and seem to be superior to standard techniques. Although the study is multifactorial and retrospective, this conclusion is further supported by the enhanced self-image @entity0 have during the postoperative period.

title: Concomitant use of computer image guidance, linear or sigmoid incisions after minimal shave, and liquid wound dressing with @entity2 for XXXX craniotomy or craniectomy: analysis of 225 consecutive surgical cases with antecedent historical control at one institution.

answer: @entity1