abstract: BACKGROUND: Standards for the detection of @entity4 during screening colonoscopy are widely used to measure examination quality. No such standards exist for sessile serrated @entity4 (SSAs). OBJECTIVE: To measure both the @entity4 detection rate (ADR) and SSA detection rate (SSADR) during screening colonoscopy before and after quality improvement/financial incentive measures. DESIGN: Retrospective determination of baseline ADR/SSADR by the endoscopist, followed by prospective collection of data after informing physicians of baseline detection rates. SETTING: Tertiary @entity1 center with a large @entity1 screening program. @entity0 : A total of 2833 average-risk @entity2 screening @entity0 50 to 75 years of age undergoing initial colonoscopy. DATA COLLECTION: Electronic medical records for indication and demographics, endoscopy report, and pathology report. MAIN OUTCOME MEASUREMENTS: Detection rates of @entity4 and SSAs by sex. RESULTS: The overall ADR in male and female @entity0 was 50.6% and 36.6%, respectively. The overall detection rate of advanced @entity4 in male and female @entity0 was 12.4% and 6.5%, respectively. The overall SSADR in  male and female @entity0 was 10.1% and 7.1%, respectively. In 108 @entity0 (3.8% of entire group), SSAs were the only @entity3 found. Detection rates of both types of @entity5 improved over time but did not reach statistical significance. LIMITATIONS: Single-center experience with limited sample size and small group of endoscopists. CONCLUSION: ADRs far in excess of current standards are achievable. Cecal withdrawal time is associated with the  ADR. Prevalence of SSA rivals that of advanced @entity4 and is greater than current medical literature suggests. The combination of monitoring and financial incentives did not result in statistically significant improvement in ADRs.

title: Detection rates of XXXX during screening colonoscopy: Time to revise quality standards?

answer: @entity5


abstract: BACKGROUND: Epitheliotrophic growth factors (GF) can be supplied topically to @entity0 with severe @entity3 through a variety of blood-derived products. We compared GF content in adult peripheral blood serum (PB-S) and cord blood serum (CB-S) as potential sources of GF. To limit inter-individual variability the assessment was performed in maternal- @entity0 pairs at the time of delivery. MATERIAL AND METHODS: The amounts of epidermal GF (EGF), insulin-like GF (IGF), transforming GF-beta ( @entity4 ), @entity1 ( @entity1 ) in CB units collected from the umbilical vein and PB from mothers (each group n=30) were estimated by enzyme-linked immunosorbent assays. Obstetric characteristics and haematological data were recorded from the archives of the Emilia Romagna Cord Blood Bank. Statistical evaluations were performed by Wilcoxon's test and correlations between variables were determined using Spearman's (  ) coefficient; p-values <0.05 were considered statistically significant. RESULTS: EGF, @entity4 and @entity1 levels were significantly higher in CB-S than in PB-S (median 1,254.4 vs 646.0 pg/mL, 51.3 vs 38.4  g/mL and 686.8 vs 30 pg/mL, respectively; all p<0.0001) whereas IGF content was significantly higher in PB-S than in CB-S (159.9 vs 53.5 pg/mL, respectively; p<0.0001). In CB-S, the @entity2 (+) cell concentration appeared to be related to EGF, IGF and @entity4 levels whereas white blood cell count appeared to be related to EGF and @entity4 levels. @entity1 levels showed no relation to the haematological parameters considered. Platelet counts were not related to GF level in either CB or PB. DISCUSSION: The GF content in the two blood sources was different, with CB containing larger amounts. Each GF selectively regulates cellular processes involved in @entity5 , so the use of PB or CB should be targeted to supply specific GF on the basis of the type and severity of the @entity3 .

title: Targeting growth factor supply in XXXX treatment: comparison between maternal peripheral blood and cord blood as sources for the preparation of topical eye drops.

answer: @entity3


abstract: Lens membranes, purified from @entity1 lenses, have been labeled by covalent cross-linking to membrane-bound 125I-calmodulin with @entity6 . Electrophoretic analysis in @entity4 demonstrated two major 125I-containing products of Mr = 49 000 and 36 000. That the formation of these two components was specifically inhibited by unlabeled calmodulin, or calmodulin antagonists, would indicate that the formation of these components was calmodulin-specific. The size of these two 125I-labeled components was unchanged over a range of 125I-calmodulin or @entity6 concentrations indicating that they represent 1:1 complexes between 125I-calmodulin (Mr = 17 000) and Mr-32 000 and Mr-19 000 lens membrane components respectively. Although formation of both cross-linked components exhibited an absolute dependence on @entity3 , the autoradiographic intensity of these components was enhanced when @entity0 was included with Mg2+ during the cross-linking reaction. Labeling was maximal in 10 mM @entity5 and approximately 1 microM @entity0 . Treatment of lens membranes with chymotrypsin resulted in the cleavage of @entity7 (the major lens membrane protein), with the appearance of a major proteolytic fragment of Mr = 22 000. This proteolysis was not associated with any significant change in either the size or amount of the 125I-calmodulin-labeled membrane components. These results suggest that calmodulin interacts with two membrane proteins, but not significantly with @entity7 , in the intact lens cell membrane. Our results indicate the need to maintain caution in interpreting direct @entity2 plus calmodulin effects on @entity7 and lens cell junctions.

title: Identification of the calmodulin-binding components in XXXX lens plasma membranes.

answer: @entity1


abstract: BACKGROUND: Surgery for @entity2 aims for complete @entity1 resection. Optical-based techniques can identify @entity1 and surrounding tissue through the tissue specific optical properties, absorption and scattering, which are both influenced by the biochemical and morphological composition of the tissue. OBJECTIVE: To evaluate the feasibility of dual-modality Diffuse Reflectance Spectroscopy-Fluorescence Spectroscopy (DRS-FS) for discrimination between healthy and malignant tissue in colorectal surgery. METHODS: Surgical specimens from @entity2 @entity0 were measured immediately after resection using a fiber-optic needle capable of dual-modality DRS-FS. Model-based analyses were used to derive scattering and absorption coefficients and intrinsic fluorescence. Volume fractions of chromophores were estimated. Furthermore, optical data were recorded along a trajectory from healthy tissue towards @entity1 . RESULTS: Spectral characteristics were identified in 1,273 measured spectra from 21 specimens. Combined DRS and FS discriminated @entity1 from surrounding tissue with a sensitivity of 95% and a specificity of 88%. Significant spectral changes were seen along the trajectory from healthy tissue to @entity1 . CONCLUSION: This study demonstrates that dual-modality DRS-FS can identify @entity2 from surrounding healthy tissue. The quantification of comprehensible parameters allows robust classification and facilitates extrapolation towards the clinical setting. The technique, here demonstrated in a needle like probe, can be incorporated into surgical tools for optically guided surgery in the near future. Lasers Surg. Med. 9999:XX-XX, 2015.    2015 Wiley Periodicals, Inc.

title: Differentiation of healthy and malignant tissue in colon cancer XXXX using optical spectroscopy: A tool for image-guided surgery.

answer: @entity0


abstract: An electron microscopic analysis of @entity0 in a congenitally blind strain of @entity1 is presented. The mutation was named rd, meaning ' @entity2 '. Although the chicks were behaviorally and electrophysiologically blind at the time of hatching, their retinas appeared morphologically comparable to normal chicks at this stage. Both groups had well-developed photoreceptor cells, although outer segments were typically disoriented or misaligned. In the normal, and to some degree in the rd, retina, outer segments became organized within the first week posthatching. In the rd retina at that time, however, more outer segments were disorganized and disoriented. Disc-like membranes were also seen in some inner segments. Many photoreceptors had distended inner segment tips containing a granular cytoplasm. @entity3 was present in the subretinal space. Over the next 2-3 weeks there was a reduction in number of inner segments, outer segments and photoreceptor nuclei of both rods and cones. Photoreceptor cell bodies in the outer nuclear layer were replaced by Mueller cell processes. By the end of the second month, a larger cone:rod ratio was apparent, and a large proportion of the remaining cones were double cones. Intact outer segments were rarely seen at that time. Few and sporadic cone cells, identified by a pale-staining oil droplet, were the predominant surviving photoreceptors by 6 months of age. At the later stages examined, the @entity4 ( @entity4 ) appeared to be undergoing degenerative changes. A general thinning of cells and hypopigmentation of @entity4 cells was apparent, although hyperpigmented, @entity4 cells were also present which bulged into the subretinal space. Pigmented cells of unknown origin were also noted in the subretinal space at the later time points.

title: XXXX in the Rhode Island Red @entity1 : ultrastructural analysis.

answer: @entity2


abstract: An electron microscopic analysis of @entity0 in a congenitally blind strain of @entity1 is presented. The mutation was named rd, meaning ' @entity2 '. Although the chicks were behaviorally and electrophysiologically blind at the time of hatching, their retinas appeared morphologically comparable to normal chicks at this stage. Both groups had well-developed photoreceptor cells, although outer segments were typically disoriented or misaligned. In the normal, and to some degree in the rd, retina, outer segments became organized within the first week posthatching. In the rd retina at that time, however, more outer segments were disorganized and disoriented. Disc-like membranes were also seen in some inner segments. Many photoreceptors had distended inner segment tips containing a granular cytoplasm. @entity3 was present in the subretinal space. Over the next 2-3 weeks there was a reduction in number of inner segments, outer segments and photoreceptor nuclei of both rods and cones. Photoreceptor cell bodies in the outer nuclear layer were replaced by Mueller cell processes. By the end of the second month, a larger cone:rod ratio was apparent, and a large proportion of the remaining cones were double cones. Intact outer segments were rarely seen at that time. Few and sporadic cone cells, identified by a pale-staining oil droplet, were the predominant surviving photoreceptors by 6 months of age. At the later stages examined, the @entity4 ( @entity4 ) appeared to be undergoing degenerative changes. A general thinning of cells and hypopigmentation of @entity4 cells was apparent, although hyperpigmented, @entity4 cells were also present which bulged into the subretinal space. Pigmented cells of unknown origin were also noted in the subretinal space at the later time points.

title: @entity2 in the Rhode Island Red XXXX : ultrastructural analysis.

answer: @entity1


abstract: BACKGROUND: Exclusive breastfeeding is recommended in the first 6 months of life, especially for @entity0 born to @entity0 with a history of @entity1 ( @entity1 ). Yet, @entity0 with a history of @entity1 face challenges with exclusive breastfeeding in the early postpartum period, a critical period for setting up longer term breastfeeding success. Minimal research has been published on associated risk factors for not exclusively breastfeeding. OBJECTIVE: The purpose of this study was to examine the association between @entity1 and exclusive breastfeeding at hospital discharge. METHODS: We conducted a cross-sectional analysis including 2038 @entity0 who participated in the population-based @entity0 Feeding Practices Study II between May 2005 and June 2007. RESULTS: @entity1 prevalence was 5.8%. The crude prevalence of exclusive breastfeeding at hospital discharge was 62.2% among @entity0 with @entity1 compared to 75.4% of @entity0 without @entity1 (P < .01). After adjusting for sociodemographic, behavioral, and anthropometric factors, the odds of exclusive breastfeeding were lower among @entity0 with @entity1 compared to @entity0 without @entity1 (odds ratio = 0.59; 95% confidence interval, 0.39-0.92). Furthermore, @entity0 who had gestational weight gain (GWG) below the Institute of Medicine guidelines had lower odds of exclusive breastfeeding compared to @entity0 who had normal GWG (odds ratio = 0.62; 95% confidence interval, 0.45-0.85). CONCLUSION: @entity0 with @entity1 history and @entity0 with inadequate GWG may need additional education to promote exclusive breastfeeding during maternal hospital stay. It is important for health care providers to assess both factors when providing education on exclusive breastfeeding and to support these @entity0 's breastfeeding efforts in the early postpartum period to maximize potential for longer term breastfeeding success.

title: Association between History of Gestational XXXX and Exclusive Breastfeeding at Hospital Discharge.

answer: @entity1


abstract: UNASSIGNED: Age-related changes in @entity3 are associated with increased risk of cardiovascular mortality and morbidity. The aim of the present study was to define the effect of age on the relationship between @entity3 . Haemodynamic and gas exchange measurements were performed at rest and peak exercise in healthy individuals. Augmentation index was measured at rest. Cardiac power output, a measure of overall cardiac function, was calculated as the product of cardiac output and mean arterial blood pressure. Augmentation index was significantly higher in older than younger @entity0 (27.7  10.1 vs. 2.5  10.1%, P<0.01). Older @entity0 demonstrated significantly higher @entity2 volume and mean arterial blood pressure (P<0.05), but lower heart rate (145  13 vs. 172  10 beats/min, P<0.01) and peak @entity1 consumption (22.5  5.2 vs. 41.2  8.4ml/kg/min, P<0.01). There was a significant negative relationship between augmentation index and peak exercise cardiac power output (r=-0.73, P=0.02) and cardiac output (r=-0.69, P=0.03) in older @entity0 . Older @entity0 maintain maximal cardiac function due to increased @entity2 volume. Vascular function is a strong predictor of overall cardiac function in older but in not younger @entity0 .

title: The effect of age on the relationship between XXXX .

answer: @entity3


abstract: BACKGROUND: @entity1 caused by the @entity5 ) is endemic in East Africa. Recent, dramatic, increases in the incidence of @entity1 in the United States and Europe are linked to the same high risk HPV genotypes responsible for @entity1 . Currently, there is extremely limited data regarding the role of HPV in @entity2 in Africa. Evidence of HPV as an etiologic agent in @entity2 in Africa would have important prevention and treatment implications. METHODS: A retrospective single institution review of oral tongue and @entity3 diagnosed between 2005 and 2013 was performed. Individual case data for 51 @entity0 with biopsy proven @entity3 ( @entity3 ) from the oropharynx (n=22) and oral tongue (n=29) were identified. Formalin fixed, paraffin embedded biopsy samples were obtained and evaluated for @entity4 by immunohistochemistry and HPV genotype 16 specific oncogenes, E6 and E7, by PCR. RESULTS: All of the positive controls, but none of the oropharyngeal samples stained positively for @entity4 . Two of the oral tongue samples stained positive for @entity4 . None of the oropharyngeal or oral tongue cases demonstrated PCR products for @entity6 E6 or E7. CONCLUSIONS: Though Mozambique has extremely high levels of HPV positive @entity1 this study demonstrates an absence of HPV positive oropharyngeal or oral @entity3 within biopsy samples from a single referral hospital in Maputo, the capital of Mozambique.

title: Investigation of the presence of HPV related oropharyngeal and oral XXXX in Mozambique.

answer: @entity3


abstract: BACKGROUND: To evaluate the regulation of blood supply in primary @entity2 through @entity6 ( @entity5 -1)/Phosphoinositol-3 Kinase ( @entity8 ). METHODS: The expression of @entity5 -1 and @entity8 was analyzed in 51 paraffin sections of metastatic (n   =   30) and non-metastastic @entity2 (n   =   21). Two trained observers quantified @entity5 -1 and @entity8 immunfluorecensce expression by determining intensity of staining and percentage of positive cells. The expression was correlated with known prognostic factors. Besides angiogenesis by means of @entity7 expression, the normal vasculature ( @entity4 Factor expression) were evaluated semi-quantitatively. Vasculogenic mimicry (VM) was analyzed by @entity3 /PAS staining. RESULTS: All examined specimens expressed @entity5 -1 with a mean of 90.34 % @entity5 -1 positive cells (range, 3.23-100%). @entity0 was associated with a higher @entity5 -1 expression. The correlation of @entity5 -1 with well-established prognostic factors showed a significant association between @entity5 -1 expression and largest @entity1 diameter (p   =   0.022), @entity9 -classification (p   =   0.008), and invasion of optic nerve head (p   =   0.048). @entity8 was expressed by all @entity2 with a mean of 87.28% cells showing @entity8 expression. A higher level of @entity8 was significantly associated with larger height (p   =   0.042) and progressed TNM-stage (p   =   0.016). The percentage of @entity8 and @entity5 -1 positive cells were significantly associated (p   =   0.034). For @entity8 and @entity5 -1 expression a non-significant association with VM was shown (p   =   0.064 and p   =   0.072, respectively). No correlation of @entity8 or @entity5 -1 with angiogenesis or mature vasculature was seen (p   >   0.05). CONCLUSIONS: @entity5 -1 expression may be especially up-regulated in larger @entity2 . As it was correlated with @entity8 expression and VM in this series of @entity2 , @entity5 -1 might induce the formation of VM via the @entity8 -signalling cascade. This article is protected by copyright. All rights reserved.

title: Analysis of XXXX and Phosphoinositol-3 Kinase expression in primary @entity2 .

answer: @entity6


abstract: BACKGROUND: To evaluate the regulation of blood supply in primary @entity2 through @entity6 ( @entity5 -1)/Phosphoinositol-3 Kinase ( @entity8 ). METHODS: The expression of @entity5 -1 and @entity8 was analyzed in 51 paraffin sections of metastatic (n   =   30) and non-metastastic @entity2 (n   =   21). Two trained observers quantified @entity5 -1 and @entity8 immunfluorecensce expression by determining intensity of staining and percentage of positive cells. The expression was correlated with known prognostic factors. Besides angiogenesis by means of @entity7 expression, the normal vasculature ( @entity4 Factor expression) were evaluated semi-quantitatively. Vasculogenic mimicry (VM) was analyzed by @entity3 /PAS staining. RESULTS: All examined specimens expressed @entity5 -1 with a mean of 90.34 % @entity5 -1 positive cells (range, 3.23-100%). @entity0 was associated with a higher @entity5 -1 expression. The correlation of @entity5 -1 with well-established prognostic factors showed a significant association between @entity5 -1 expression and largest @entity1 diameter (p   =   0.022), @entity9 -classification (p   =   0.008), and invasion of optic nerve head (p   =   0.048). @entity8 was expressed by all @entity2 with a mean of 87.28% cells showing @entity8 expression. A higher level of @entity8 was significantly associated with larger height (p   =   0.042) and progressed TNM-stage (p   =   0.016). The percentage of @entity8 and @entity5 -1 positive cells were significantly associated (p   =   0.034). For @entity8 and @entity5 -1 expression a non-significant association with VM was shown (p   =   0.064 and p   =   0.072, respectively). No correlation of @entity8 or @entity5 -1 with angiogenesis or mature vasculature was seen (p   >   0.05). CONCLUSIONS: @entity5 -1 expression may be especially up-regulated in larger @entity2 . As it was correlated with @entity8 expression and VM in this series of @entity2 , @entity5 -1 might induce the formation of VM via the @entity8 -signalling cascade. This article is protected by copyright. All rights reserved.

title: Analysis of @entity6 and Phosphoinositol-3 Kinase expression in primary XXXX .

answer: @entity2


abstract: OBJECTIVE: Experts recommend that @entity0 engage in 60 minutes of daily moderate to vigorous PA (PA), but few meet these goals. Exergames like "Dance Dance Revolution" (DDR) (Konami of America, Redwood City, CA) have the potential to provide PA. We sought to determine if DDR would boost PA among overweight or @entity1 @entity0 . SUBJECTS AND METHODS: @entity0 over the 85th percentile for body mass index (BMI) and between 9 and 17 years old were randomly assigned to receive DDR+pedometers (treatment group) or pedometers only (comparison group). PA levels were tracked for 12 weeks by self-report, pedometer, and accelerometer data. RESULTS: Sixty-five families completed the study. The average BMI percentile of the @entity0 was over 96 percent. Despite randomization, @entity0 in the treatment (DDR) group were more often male, older, and heavier than @entity0 in the comparison group. Self-reported frequency of moderate to vigorous PA increased significantly from baseline to 12 weeks for the treatment group and declined for the comparison group. Accelerometer results indicated a significant decline in moderate activity over time for the comparison group. However, there were no significant between-group differences based on the accelerometer or pedometer data. CONCLUSION: Based on self-report measures, DDR may have increased PA levels in @entity1 and overweight @entity0 . However, we are led to question the validity of these results because analyses based on objective measures do not confirm them. Accelerometer results indicate that although DDR did not boost PA, it may have helped to slow the decline in moderate to vigorous PA over time.

title: Comparative Effectiveness of a 12-Week Physical Activity Intervention for Overweight and XXXX : Exergaming with "Dance Dance Revolution".

answer: @entity1


abstract: UNASSIGNED: Milk fat globule membrane ( @entity5 ) proteins are known to be involved in many biological functions; however, their components and inter-species complexity have not yet been completely elucidated. We investigated the protein composition of the @entity5 -enriched fraction from Holstein, Jersey, @entity7 , buffalo, @entity3 , @entity6 , @entity4 , and @entity0 . Extracted proteins from the @entity5 -enriched fractions were identified and quantified by an iTRAQ proteomic approach. We identified 520 protein species categorized as biological processes, cellular components and molecular function according to their annotation. Cellular process, localization, transport, signal transduction, and response to stimulus were the most common biological processes; binding and catalytic activities were the most prevalent molecular functions. Pathway analysis revealed several pathways, including glycolysis/gluconeogenesis, peroxisome proliferator-activated receptor signaling, and @entity2 biosynthesis. Quantified @entity5 -enriched proteins were subjected to discriminative proteomic profiling by principal component analysis and a hierarchical clustering method, and then organized into four major clusters: (1) Holstein, Jersey, and @entity7 milk; (2) buffalo and @entity3 milk; (3) Holstein, Jersey, buffalo, @entity7 , and @entity3 milk; and (4) @entity6 , @entity4 , and @entity0 milk. These novel quantitative data provide insight into the protein composition of the @entity5 and their potential physiological functions, and highlight the significant differences in the @entity5 fractions among @entity0 species. BIOLOGICAL SIGNIFICANCE: Milk fat globule membrane ( @entity5 ) proteins have exhibited a relatively larger diversity than other milk fractions, and implicated health beneficial effects. Proteomic analysis of @entity5 protein was mainly focused on @entity0 , @entity1 and @entity3 in previous studies. Recently, there is an increasing demand for natural milk from minor dairy animals. Differences in protein components were not yet elucidated that required the integration of this information across multiple species. Thus, iTRAQ analysis of the proteins in @entity5 fractions from Holstein, Jersey, @entity7 , buffalo, @entity3 , @entity6 , @entity4 , and @entity0 was performed in this study. A total of 520 proteins were identified and quantified in the @entity5 fractions. The results were contributed to a comprehensive overview and discriminative profiling of the @entity5 proteome across species.

title: Proteomic characterization and comparison of XXXX milk fat globule proteomes by iTRAQ analysis.

answer: @entity0


abstract: UNASSIGNED: @entity2 ( @entity2 ) of the pancreas are rare and frequently malignant. Our presentation of a pancreatic NEN analyzes the diagnosis circumstances, staging, treatment, one-year evolution and disease particularities. A 39-year-old nonsmoker @entity0 was admitted in the Clinic of Pulmonology, Tirgu Mures, Romania with a @entity3 suspicion (fever, @entity4 irradiated below the diaphragm, mild @entity7 ). The chest X-ray showed a rise of the left diaphragm. Abdominal ultrasound revealed a large pancreas-related @entity2 . Computerized tomography (CT) scan with contrast confirmed a well-vascularized @entity6 , which invades spleen, collateral circulation of the @entity5 without secondary lesions and no retroperitoneal adenopathies. The @entity0 was referred to the surgery where there was performed total @entity2 resection, spleen resection, and large lymphadenectomy. Histopathology and immunohistochemistry revealed the pancreatic NEN G2 grade, T3N1M0 and allowed accurate treatment. 2010 World Health Organization (WHO) @entity2 classification recommends further treatment-related biomarkers determination only in selected cases. Our case evolution after one year was favorable without local @entity2 relapse or @entity1 . The close survey of the @entity0 (by clinical exam, imaging and biological markers) is ongoing. The onset of asymptomatic @entity6 may have atypical respiratory symptoms. Imaging methods (ultrasound, contrast CT) are recommended in borderline symptomatology. Radical surgical resection of the @entity2 with lymphadenectomy, histopathology with immuno-histochemistry play an essential role in the correct diagnostic, grading, staging and treatment of pancreatic @entity2 . Close survey of the clinical, imagistic and biological markers is recommended.

title: Neuroendocrine XXXX - diagnosis circumstances, staging and treatment: a case report.

answer: @entity6


abstract: BACKGROUND: The clinical presentation of common symptoms during @entity3 episodes in @entity2 ( @entity2 ) and @entity3 ( @entity3 ) poses challenges for accurate diagnosis. @entity1 may aid the development of reliable discrimination between these two clinical conditions. METHODS: For our sample of 16 @entity2 @entity0 , 19 @entity3 @entity0 and 29 healthy volunteers, we adopted vertex-wise cortical based brain imaging techniques to examine cortical thickness and surface area, two components of cortical volume with distinct genetic determinants. Based on specific characteristics of neuroanatomical features, we then used support vector machine (SVM) algorithm to discriminate between @entity0 with @entity2 and @entity3 . RESULTS: Compared to @entity3 @entity0 , @entity2 @entity0 showed significantly larger cortical surface area in the left bankssts, precuneus, precentral, inferior parietal, superior parietal and the right middle temporal gyri. In addition, larger volumes of subcortical regions were found in @entity2 @entity0 . In SVM discriminative analyses, the overall accuracy was 74.3  %, with a sensitivity of 62.5  % and a specificity of 84.2  % (p   =   0.028). Compared to controls, larger surface area in the temporo-parietal regions were observed in @entity2 @entity0 , and thinner cortices in fronto-temporal regions were observed in @entity3 @entity0 , especially in the medial orbito-frontal area. CONCLUSIONS: These findings have demonstrated distinct spatially distributed variations in cortical thickness and surface area in @entity0 with @entity2 and @entity3 , suggesting potentially varying etiological and neuropathological processes in these two conditions. The employment of multimodal classification on disorder-specific biological features has shed light to the development of potential classification tools that could aid diagnostic decisions.

title: Distinguishing bipolar and major XXXX by brain structural morphometry: a pilot study.

answer: @entity3


abstract: OBJECTIVE: The purpose of this study is to assess sexual function, @entity4 and self esteem in @entity0 who were surgically treated for @entity1 . DESIGN: Retrospective, blind, cross sectional study. SETTING: Single tertiary @entity1 center. @entity0 : 4 @entity0 who were operated on Istanbul University Cerrahpasa School of Medicine Otorhinolaryngology Department between 2008 and 2012 were classified according to the type of the operation as total laryngectomy (Group 1) and partial laryngectomy (Group 2). MAIN OUTCOME MEASURES: @entity2 , @entity3 and self esteem were evaluated with The Arizona Sexual Experiences Scale (ASEX), Beck's @entity3 Inventory (BDI) and @entity5 ( @entity5 ) respectively. RESULTS: Average ASEX scores of the group 1 was (13,98    6,32) and group 2 was (13,08    4,96) without statistically significant difference (p=0,537). Mean BDI score of group 1 was (13,20    10,41) higher than group 2 (7,76    8,14) and the difference was significant statistically (p=0,026). Mean @entity5 scores of group 1 and group 2 were 20,68    5,33 and 19,25    4,70 respectively again without significant difference (p=0,262). However, when the average scores of each item of Rosenberg Scale were compared, significant difference was found in d4 (2,37    0,78; 1,64    0,99; p=0,001), d6 (1,22    1,05; 1,84    1,14; p=0,023), d10 (2,55    2,39; 1,28    1,49; p=0,018) and d11 (1,35    0,95; 2,00    1,41; p=0,021). BDI scores were correlated with @entity5 scores and ASEX scores were correlated with age. CONCLUSION: The @entity0 with total laryngectomy seem to have more psychological problems that must be addressed in the postoperative period. This article is protected by copyright. All rights reserved.

title: XXXX , self esteem and sexual function in @entity1 @entity0 .

answer: @entity3


abstract: OBJECTIVE: The purpose of this study is to assess sexual function, @entity4 and self esteem in @entity0 who were surgically treated for @entity1 . DESIGN: Retrospective, blind, cross sectional study. SETTING: Single tertiary @entity1 center. @entity0 : 4 @entity0 who were operated on Istanbul University Cerrahpasa School of Medicine Otorhinolaryngology Department between 2008 and 2012 were classified according to the type of the operation as total laryngectomy (Group 1) and partial laryngectomy (Group 2). MAIN OUTCOME MEASURES: @entity2 , @entity3 and self esteem were evaluated with The Arizona Sexual Experiences Scale (ASEX), Beck's @entity3 Inventory (BDI) and @entity5 ( @entity5 ) respectively. RESULTS: Average ASEX scores of the group 1 was (13,98    6,32) and group 2 was (13,08    4,96) without statistically significant difference (p=0,537). Mean BDI score of group 1 was (13,20    10,41) higher than group 2 (7,76    8,14) and the difference was significant statistically (p=0,026). Mean @entity5 scores of group 1 and group 2 were 20,68    5,33 and 19,25    4,70 respectively again without significant difference (p=0,262). However, when the average scores of each item of Rosenberg Scale were compared, significant difference was found in d4 (2,37    0,78; 1,64    0,99; p=0,001), d6 (1,22    1,05; 1,84    1,14; p=0,023), d10 (2,55    2,39; 1,28    1,49; p=0,018) and d11 (1,35    0,95; 2,00    1,41; p=0,021). BDI scores were correlated with @entity5 scores and ASEX scores were correlated with age. CONCLUSION: The @entity0 with total laryngectomy seem to have more psychological problems that must be addressed in the postoperative period. This article is protected by copyright. All rights reserved.

title: @entity3 , self esteem and sexual function in XXXX @entity0 .

answer: @entity1


abstract: OBJECTIVE: The purpose of this study is to assess sexual function, @entity4 and self esteem in @entity0 who were surgically treated for @entity1 . DESIGN: Retrospective, blind, cross sectional study. SETTING: Single tertiary @entity1 center. @entity0 : 4 @entity0 who were operated on Istanbul University Cerrahpasa School of Medicine Otorhinolaryngology Department between 2008 and 2012 were classified according to the type of the operation as total laryngectomy (Group 1) and partial laryngectomy (Group 2). MAIN OUTCOME MEASURES: @entity2 , @entity3 and self esteem were evaluated with The Arizona Sexual Experiences Scale (ASEX), Beck's @entity3 Inventory (BDI) and @entity5 ( @entity5 ) respectively. RESULTS: Average ASEX scores of the group 1 was (13,98    6,32) and group 2 was (13,08    4,96) without statistically significant difference (p=0,537). Mean BDI score of group 1 was (13,20    10,41) higher than group 2 (7,76    8,14) and the difference was significant statistically (p=0,026). Mean @entity5 scores of group 1 and group 2 were 20,68    5,33 and 19,25    4,70 respectively again without significant difference (p=0,262). However, when the average scores of each item of Rosenberg Scale were compared, significant difference was found in d4 (2,37    0,78; 1,64    0,99; p=0,001), d6 (1,22    1,05; 1,84    1,14; p=0,023), d10 (2,55    2,39; 1,28    1,49; p=0,018) and d11 (1,35    0,95; 2,00    1,41; p=0,021). BDI scores were correlated with @entity5 scores and ASEX scores were correlated with age. CONCLUSION: The @entity0 with total laryngectomy seem to have more psychological problems that must be addressed in the postoperative period. This article is protected by copyright. All rights reserved.

title: @entity3 , self esteem and sexual function in @entity1 XXXX .

answer: @entity0


abstract: OBJECTIVES: This study sought to investigate the clinical outcomes based on the assessment of quantitative coronary angiography-maximal lumen diameter (Dmax). BACKGROUND: Assessment of pre-procedural Dmax of proximal and distal sites has been used for Absorb scaffold size selection in the ABSORB studies. METHODS: A total of 1,248 @entity0 received Absorb scaffolds in the ABSORB Cohort B (ABSORB Clinical Investigation, Cohort B) study (N  = 101), ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) study (N  = 812), and ABSORB II (ABSORB II Randomized Controlled Trial) trial (N  = 335). The incidence of major adverse @entity4 (MACE) (a composite of @entity3 , any @entity5 [ @entity5 ], and @entity1 -driven @entity2 revascularization) was analyzed according to the Dmax subclassification of scaffold oversize group versus scaffold nonoversize group. RESULTS: Of 1,248 @entity0 , pre-procedural Dmax was assessed in 1,232 @entity0 (98.7%). In 649 (52.7%) @entity0 , both proximal and distal Dmax values were smaller than the nominal size of the implanted scaffold (scaffold oversize group), whereas in 583 (47.3%) of @entity0 , the proximal and/or distal Dmax were larger than the implanted scaffold (scaffold nonoversize group). The rates of MACE and @entity5 at 1 year were significantly higher in the scaffold oversize group than in the scaffold nonoversize group (MACE 6.6% vs. 3.3%; log-rank p  < 0.01, all @entity5 : 4.6% vs. 2.4%; log-rank p  = 0.04), mainly driven by a higher @entity5 rate within 1 month post-procedure (3.5% vs. 1.9%; p  = 0.08). The independent MACE determinants were both Dmax smaller than the scaffold nominal size (odds ratio [OR]: 2.13, 95% confidence interval [CI]: 1.22 to 3.70; p  < 0.01) and the implantation of overlapping scaffolds (OR: 2.10, 95% CI: 1.17 to 3.80; p  = 0.01). CONCLUSIONS: Implantation of an oversized Absorb scaffold in a relatively small vessel appears to be associated with a higher 1-year MACE rate driven by more frequent early @entity5 . (ABSORB Clinical Investigation, Cohort B [ABSORB Cohort B], NCT00856856; ABSORB EXTEND Clinical Investigation [ABSORB EXTEND], NCT01023789; ABSORB II Randomized Controlled Trial [ABSORB II], NCT01425281).

title: Relation Between Bioresorbable Scaffold Sizing Using QCA-Dmax and Clinical Outcomes at 1  Year in 1,232 XXXX From 3 Study Cohorts (ABSORB Cohort B, ABSORB EXTEND, and ABSORB II).

answer: @entity0


abstract: 1. Ion and water content of @entity2 intestinal mucosa, stripped free from muscular layers were measured under various incubation conditions. 2. Ouabain induces an increase in cation content that is electrically compensated for by @entity4 . The increase in solute content is accompanied by an increase in water content. 3. When extracellular @entity4 is partially replaced by @entity1 , @entity5 does induce cell shrinkage. 4. @entity0 induces a rapid increase in cell volume that is restored by oxygenation of the incubation solution. Ouabain prevents the restoration of volume. 5. It is concluded that the classical ouabain-sensitive Na/K pump participates in the maintenance of cellular volume. We suggest that the constancy in volume after ouabain poisoning as is reported for many tissues might be due to a low @entity4 conductance of its membranes. 6. Anisotonic media (range: 0.6-1.2 isotonicity), made by variation on @entity3 concentration, induce changes in cell water content that deviates from the simplified van't Hoff equation by about 10%. No change in water content after the initial increase was found. 7. We conclude that @entity2 enterocytes do not possess a mechanism for rapid volume readjustment.

title: Cell volume regulation in XXXX intestinal mucosa.

answer: @entity2


abstract: AIM: To retrospectively analyze factors affecting the long-term survival of @entity0 with @entity3 who underwent pancreatic resection. METHODS: From January 2000 to December 2011, 195 @entity0 underwent pancreatic resection in our hospital. The prognostic factors after pancreatic resection were analyzed in all 195 @entity0 . After excluding the censored cases within an observational period, the clinicopathological characteristics of 20 @entity0 who survived >=  5 (n = 20) and < 5 (n = 76) years were compared. For this comparison, we analyzed the @entity0 who underwent surgery before June 2008 and were observed for more than 5 years. For statistical analyses, the log-rank test was used to compare the cumulative survival rates, and the    (2) and Mann-Whitney tests were used to compare the two groups. The Cox-Hazard model was used for a multivariate analysis, and P values less than 0.05 were considered significant. A multivariate analysis was conducted on the factors that were significant in the univariate analysis. RESULTS: The median survival for all @entity0 was 27.1 months, and the 5-year actuarial survival rate was 34.5%. The median observational period was 595 d. With the univariate analysis, the UICC stage was significantly associated with survival time, and the CA19-9  <= 200 U/mL, DUPAN-2  <= 180 U/mL, @entity2 size  <= 20 mm, R0 resection, absence of lymph node @entity1 , absence of extrapancreatic @entity1 , and absence of portal invasion were favorable prognostic factors. The multivariate analysis showed that @entity2 size  <= 20 mm (HR = 0.40; 95%CI: 0.17-0.83, P = 0.012) and negative surgical margins (R0 resection) (HR = 0.48; 95%CI: 0.30-0.77, P = 0.003) were independent favorable prognostic factors. Among the 96 @entity0 , 20 @entity0 survived for 5 years or more, and 76 @entity0 died within 5 years after operation. Comparison of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2 (79.5 vs 312.5 U/mL, P = 0.032), @entity2 size  <= 20 mm (35% vs 8%, P = 0.008), R0 resection (95% vs 61%, P = 0.004), and absence of lymph node @entity1 (60% vs 18%, P = 0.036) were significantly associated with the 5-year survival. CONCLUSION: Negative surgical margins and a @entity2 size  <= 20 mm were independent favorable prognostic factors. Histologically curative resection and early @entity2 detection are important factors in achieving long-term survival.

title: Long-term survival after resection of XXXX : a single-center retrospective analysis.

answer: @entity3


abstract: AIM: To elucidate the association between @entity2 ( @entity2 ) and positive @entity6 ( @entity6 ) in @entity0 with obscure @entity3 (OGIB). METHODS: Between February 2008 and August 2013, 202 @entity0 with OGIB who performed both capsule endoscopy (CE) and @entity6 were enrolled (mean age; 63.6    14.0 years, 118 males, 96 previous overt @entity4 , 106 with @entity4 ). All @entity0 underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on @entity6 results. The prevalence of @entity2 was compared between @entity0 with positive and negative @entity6 . RESULTS: CE revealed @entity2 in 72 @entity0 (36%). @entity6 was positive in 100 @entity0 (50%) and negative in 102 (50%). The prevalence of @entity2 was significantly higher in @entity0 with positive @entity6 than those with negative @entity6 (46% vs 25%, P = 0.002). In particular, among @entity0 with occult OGIB, the prevalence of @entity2 was higher in positive @entity6 group than negative @entity6 group (45% vs 18%, P = 0.002). On the other hand, among @entity0 with previous overt OGIB, there was no significant difference in the prevalence of @entity2 between positive and negative @entity6 group (47% vs 33%, P = 0.18). In disease specific analysis among @entity0 with occult OGIB, the prevalence of @entity5 and @entity1 were higher in positive @entity6 group than negative @entity6 group. In multivariate analysis, only positive @entity6 was a predictive factors of @entity2 in @entity0 with OGIB (OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evident among @entity0 with occult OGIB who underwent @entity6 on the same day or a day before CE. The prevalence of @entity2 in positive vs negative @entity6 group were 54% vs 13% in @entity0 with occult OGIB who underwent @entity6 on the same day or the day before CE (P = 0.001), while there was no significant difference between positive and negative @entity6 group in those who underwent @entity6 two or more days before CE (43% vs 25%, P = 0.20). CONCLUSION: The present study suggests that positive @entity6 may be useful for predicting @entity2 in @entity0 with occult OGIB. Positive @entity6 indicates higher likelihood of @entity5 or @entity1 in @entity0 with occult OGIB. Undergoing CE within a day after @entity6 achieved a higher diagnostic yield for @entity0 with occult OGIB.

title: Impact of fecal occult blood on obscure XXXX : observational study.

answer: @entity3


abstract: UNASSIGNED: Cell apoptosis induced by endoplasmic reticulum (ER) stress appears to be one of the main causes of @entity2 following @entity3 /reperfusion (MI/R). The @entity5 ( @entity5 ) pathway is the main pathway through which apoptosis is induced during ER stress. @entity4 ( @entity4 ) is an important protein involved in the @entity5 pathway. The present study investigated the hypothesis that MI/R activates the @entity5 pathway through signaling via a pathway involving PKR-like ER kinase (PERK), a-subunit of eukaryotic initiation factor 2 ( @entity7 ) and @entity6 ( @entity6 ). Immunohistochemical staining of the heart tissues from spontaneously hypersensitive @entity0 indicated that MI/R injury increases @entity5 and GPR78 protein expression levels. To further analyze the mechanism by which MI/R injury induces apoptosis by ER stress, the expression levels of five marker proteins involved in the hypothetical PERK- @entity7 - @entity6 pathway were detected, namely PERK, phosphorylated PERK (P-PERK), @entity7 , phosphorylated @entity7 (P- @entity7 ) and @entity6 . An increase in the collective expression levels of these proteins would indicate that apoptosis was induced by this signaling pathway. In addition, the study also explored whether @entity1 affects the signaling pathway of MI/R-induced @entity2 by treating spontaneously @entity1 @entity0 (SHRs) with captopril (an effective drug used to treat @entity1 ). @entity0 treated with captopril experienced a reduction in blood pressure to normal levels, but no marked differences in the expression levels of the tested proteins or in MI/R injury severity compared with those in untreated @entity0 . These results suggest that MI/R activates the @entity5 pathway during ER stress by activating the PERK- @entity7 - @entity6 pathway and that @entity1 does not affect this signaling pathway.

title: Endoplasmic reticulum stress response in spontaneously XXXX @entity0 is affected by @entity3 reperfusion injury.

answer: @entity1


abstract: UNASSIGNED: Cell apoptosis induced by endoplasmic reticulum (ER) stress appears to be one of the main causes of @entity2 following @entity3 /reperfusion (MI/R). The @entity5 ( @entity5 ) pathway is the main pathway through which apoptosis is induced during ER stress. @entity4 ( @entity4 ) is an important protein involved in the @entity5 pathway. The present study investigated the hypothesis that MI/R activates the @entity5 pathway through signaling via a pathway involving PKR-like ER kinase (PERK), a-subunit of eukaryotic initiation factor 2 ( @entity7 ) and @entity6 ( @entity6 ). Immunohistochemical staining of the heart tissues from spontaneously hypersensitive @entity0 indicated that MI/R injury increases @entity5 and GPR78 protein expression levels. To further analyze the mechanism by which MI/R injury induces apoptosis by ER stress, the expression levels of five marker proteins involved in the hypothetical PERK- @entity7 - @entity6 pathway were detected, namely PERK, phosphorylated PERK (P-PERK), @entity7 , phosphorylated @entity7 (P- @entity7 ) and @entity6 . An increase in the collective expression levels of these proteins would indicate that apoptosis was induced by this signaling pathway. In addition, the study also explored whether @entity1 affects the signaling pathway of MI/R-induced @entity2 by treating spontaneously @entity1 @entity0 (SHRs) with captopril (an effective drug used to treat @entity1 ). @entity0 treated with captopril experienced a reduction in blood pressure to normal levels, but no marked differences in the expression levels of the tested proteins or in MI/R injury severity compared with those in untreated @entity0 . These results suggest that MI/R activates the @entity5 pathway during ER stress by activating the PERK- @entity7 - @entity6 pathway and that @entity1 does not affect this signaling pathway.

title: Endoplasmic reticulum stress response in spontaneously @entity1 @entity0 is affected by XXXX reperfusion injury.

answer: @entity3


abstract: UNASSIGNED: Cell apoptosis induced by endoplasmic reticulum (ER) stress appears to be one of the main causes of @entity2 following @entity3 /reperfusion (MI/R). The @entity5 ( @entity5 ) pathway is the main pathway through which apoptosis is induced during ER stress. @entity4 ( @entity4 ) is an important protein involved in the @entity5 pathway. The present study investigated the hypothesis that MI/R activates the @entity5 pathway through signaling via a pathway involving PKR-like ER kinase (PERK), a-subunit of eukaryotic initiation factor 2 ( @entity7 ) and @entity6 ( @entity6 ). Immunohistochemical staining of the heart tissues from spontaneously hypersensitive @entity0 indicated that MI/R injury increases @entity5 and GPR78 protein expression levels. To further analyze the mechanism by which MI/R injury induces apoptosis by ER stress, the expression levels of five marker proteins involved in the hypothetical PERK- @entity7 - @entity6 pathway were detected, namely PERK, phosphorylated PERK (P-PERK), @entity7 , phosphorylated @entity7 (P- @entity7 ) and @entity6 . An increase in the collective expression levels of these proteins would indicate that apoptosis was induced by this signaling pathway. In addition, the study also explored whether @entity1 affects the signaling pathway of MI/R-induced @entity2 by treating spontaneously @entity1 @entity0 (SHRs) with captopril (an effective drug used to treat @entity1 ). @entity0 treated with captopril experienced a reduction in blood pressure to normal levels, but no marked differences in the expression levels of the tested proteins or in MI/R injury severity compared with those in untreated @entity0 . These results suggest that MI/R activates the @entity5 pathway during ER stress by activating the PERK- @entity7 - @entity6 pathway and that @entity1 does not affect this signaling pathway.

title: Endoplasmic reticulum stress response in spontaneously @entity1 XXXX is affected by @entity3 reperfusion injury.

answer: @entity0


abstract: BACKGROUND/AIMS: The incidental finding of @entity2 (SETs) is increasing with national @entity1 screening endoscopy. In a Swedish population, screening endoscopy found a prevalence of SETs of 0.36%. However, the prevalence of gastric SETs in Korean @entity0 has not been described. Therefore, this study evaluated the prevalence of SETs of the stomach in a Korean @entity0 population. METHODS: We reviewed endoscopic reports of 11,712 subjects who underwent screening esophagogastroduodenoscopy (EGD) at Hanyang University Hospital between July 2012 and June 2013. RESULTS: Among 11,712 @entity0 , 194 (1.7%) had SET of the stomach. Of these, 71 (prevalence, 0.6%) were male and 123 (prevalence, 1.1%) were female. When grouped by age, the prevalence of SET was as follows: 1.0% for @entity0 in their twenties, 6.2% for those in their thirties, 19.1% for those in their forties, 33.0% for those in their fifties, 30.4% for those in their sixties, and 10.3% for those over 70 years of age. CONCLUSIONS: The overall prevalence of gastric SET among healthy examinees was 1.7%. The prevalence of gastric SET increased with age and was higher in female.

title: Prevalence of Gastric XXXX in Korea: A Single Center Experience.

answer: @entity1


abstract: INTRODUCTION: The underlying pathophysiology of @entity1 in @entity0 with @entity4 ( @entity4 ) remains unclear. It was recently attributed to a direct cytotoxic effect of Shiga toxin 2 (Stx2) in the thalamus. Conventional MRI of @entity0 with Stx2-caused @entity4 revealed - despite severe @entity1 - only mild alterations if any, mostly in the thalamus. Against this background, we questioned: Does @entity5 ( @entity5 ) capture the thalamic damage better than conventional MRI? Are @entity1 and disease course better reflected by thalamic alterations as detected by @entity5 ? Are other brain regions also affected? METHODS: Three @entity0 with serious @entity2 due to Stx2-associated @entity4 were admitted to MRI/ @entity5 at disease onset. Two of them were longitudinally examined. Fractional anisotropy (FA) and mean diffusivity were computed to assess Stx2-caused @entity1 . RESULTS: Compared to 90 healthy @entity0 , all three @entity0 had significantly reduced thalamic FA. Thalamic mean diffusivity was only reduced in two @entity0 . @entity5 of the longitudinally examined @entity0 demonstrated slow normalization of thalamic FA, which was paralleled by clinical improvement. CONCLUSION: Whereas conventional MRI only shows slight alterations based on subjective evaluation, @entity5 permits quantitative, objective, and longitudinal assessment of cytotoxic @entity3 in individual @entity0 .

title: Recovery of thalamic XXXX after Shiga toxin 2-associated @entity4 .

answer: @entity1


abstract: INTRODUCTION: The underlying pathophysiology of @entity1 in @entity0 with @entity4 ( @entity4 ) remains unclear. It was recently attributed to a direct cytotoxic effect of Shiga toxin 2 (Stx2) in the thalamus. Conventional MRI of @entity0 with Stx2-caused @entity4 revealed - despite severe @entity1 - only mild alterations if any, mostly in the thalamus. Against this background, we questioned: Does @entity5 ( @entity5 ) capture the thalamic damage better than conventional MRI? Are @entity1 and disease course better reflected by thalamic alterations as detected by @entity5 ? Are other brain regions also affected? METHODS: Three @entity0 with serious @entity2 due to Stx2-associated @entity4 were admitted to MRI/ @entity5 at disease onset. Two of them were longitudinally examined. Fractional anisotropy (FA) and mean diffusivity were computed to assess Stx2-caused @entity1 . RESULTS: Compared to 90 healthy @entity0 , all three @entity0 had significantly reduced thalamic FA. Thalamic mean diffusivity was only reduced in two @entity0 . @entity5 of the longitudinally examined @entity0 demonstrated slow normalization of thalamic FA, which was paralleled by clinical improvement. CONCLUSION: Whereas conventional MRI only shows slight alterations based on subjective evaluation, @entity5 permits quantitative, objective, and longitudinal assessment of cytotoxic @entity3 in individual @entity0 .

title: Recovery of thalamic @entity1 after Shiga toxin 2-associated XXXX .

answer: @entity4


abstract: Angiogenesis is important processes for @entity2 growth and @entity1 . Anti-angiogenesis target therapy has recently been known to be new anti- @entity2 therapeutic strategies. Natural products such as traditional medicine comprise a major source of angiogenesis inhibitors. Artemisia lavandulaefolia has been known to use in the traditional medical practices. However, its molecular mechanism on the @entity2 protection and therapy was not clearly elucidated. In this study, we investigated the possibility that extract of A. lavandulaefolia inhibits in vitro angiogenesis. Therefore, we examined the effect of extract of A. lavandulaefolia on the vascular network formation of @entity0 umbilical vein endothelial cells (HUVECs). We found that the treatment of A. lavandulaefolia extract suppressed the tube formation of HUVECs without any influence on the viability of HUVECs. In addition, extract of A. lavandulaefolia inhibited the migration and invasion of HUVECs. These results suggest that extract of A. lavandulaefolia could be act for an angiogenic inhibitor.

title: Extract of Artemisia lavandulaefolia Inhibits In Vitro Angiogenesis in XXXX Umbilical Vein Endothelial Cells.

answer: @entity0


abstract: BACKGROUND: Although @entity1 repair with mesh can be successful, prophylactic mesh augmentation (PMA) represents a potentially useful preventative technique to mitigate incisional @entity1 risk in select high-risk @entity0 . The efficacy, cost-benefit, and societal value of such an intervention are not known. The aim of this study was to determine the cost-utility of using prophylactic mesh to augment @entity4 . METHODS: A decision tree model was employed to evaluate the cost-utility of using PMA relative to @entity2 ( @entity2 ) after elective laparotomy. The authors adopted the societal perspective for cost and utility estimates. A systematic review of the literature on PMA was performed. The costs in this study included direct hospital costs and indirect costs to society, and utilities were obtained through a survey of 300 English-speaking members of the general public evaluating 14 health state scenarios relating to @entity3 . RESULTS: @entity2 without mesh demonstrated an expected average cost of  17,182 (average quality-adjusted life-year [QALY] of 21.17) compared with  15,450 (expected QALY was 21.21) for PMA. @entity2 was associated with an incremental cost-efficacy ratio (ICER) of - 42,444/QALY compared with PMA such that PMA was more effective and less costly. Monte Carlo sensitivity analysis was performed demonstrating more simulations resulting in ICERs for @entity2 above the willingness-to-pay threshold of  50,000/QALY, supporting the finding that PMA is superior. CONCLUSION: Cost-utility analysis of @entity2 compared to PMA for abdominal laparotomy closure demonstrates PMA to be more effective, less costly, and overall more cost-effective than @entity2 .

title: Cost-utility analysis of the use of  prophylactic mesh augmentation compared with primary fascial suture repair in @entity0 at high risk for  incisional XXXX .

answer: @entity1


abstract: BACKGROUND: Although @entity1 repair with mesh can be successful, prophylactic mesh augmentation (PMA) represents a potentially useful preventative technique to mitigate incisional @entity1 risk in select high-risk @entity0 . The efficacy, cost-benefit, and societal value of such an intervention are not known. The aim of this study was to determine the cost-utility of using prophylactic mesh to augment @entity4 . METHODS: A decision tree model was employed to evaluate the cost-utility of using PMA relative to @entity2 ( @entity2 ) after elective laparotomy. The authors adopted the societal perspective for cost and utility estimates. A systematic review of the literature on PMA was performed. The costs in this study included direct hospital costs and indirect costs to society, and utilities were obtained through a survey of 300 English-speaking members of the general public evaluating 14 health state scenarios relating to @entity3 . RESULTS: @entity2 without mesh demonstrated an expected average cost of  17,182 (average quality-adjusted life-year [QALY] of 21.17) compared with  15,450 (expected QALY was 21.21) for PMA. @entity2 was associated with an incremental cost-efficacy ratio (ICER) of - 42,444/QALY compared with PMA such that PMA was more effective and less costly. Monte Carlo sensitivity analysis was performed demonstrating more simulations resulting in ICERs for @entity2 above the willingness-to-pay threshold of  50,000/QALY, supporting the finding that PMA is superior. CONCLUSION: Cost-utility analysis of @entity2 compared to PMA for abdominal laparotomy closure demonstrates PMA to be more effective, less costly, and overall more cost-effective than @entity2 .

title: Cost-utility analysis of the use of  prophylactic mesh augmentation compared with primary fascial suture repair in XXXX at high risk for  incisional @entity1 .

answer: @entity0


abstract: UNASSIGNED: Although recent reports indicated that produce contamination with foodborne pathogens is widespread in Nigeria, the sources and magnitude of microbial contamination of fruits and vegetables on farms and in markets have not been thoroughly identified. To ascertain possible pathways of contamination, the frequency and magnitude of coliform and @entity1 contamination of tomatoes produced in northwest Nigeria was assessed on farms and in markets. Eight hundred twenty-six @entity0 fruit samples and 36 irrigation water samples were collected and assessed for fecal indicator organisms. In addition, the awareness and use of food safety practices by @entity0 farmers and marketers were determined. Median concentration of coliforms on all field- and market-sourced @entity0 fruit samples, as well as in irrigation water sources, in Kaduna, Kano, and Katsina states exceeded 1,000 @entity2 ( @entity2 ) per g. Median @entity1 counts from 73 (17%) of 420 field samples and 231 (57%) of 406 market @entity0 fruit samples exceeded 100 @entity2 /g. Median @entity1 concentrations on @entity0 fruits were higher (P < 0.01) in the rainy season (2.45 Log @entity2 /g), when irrigation was not practiced than in the dry (1.10 Log @entity2 /g) and early dry (0.92 Log @entity2 /g) seasons. Eighteen (50%) of 36 irrigation water samples had @entity1 counts higher than 126 @entity2 /100 ml. Median @entity1 contamination on market @entity0 fruit samples (2.66 Log @entity2 /g) were higher (P < 0.001) than those from tomatoes collected on farms (0.92 Log @entity2 /g). Farmers and marketers were generally unaware of the relationship between food safety practices and microbial contamination on fresh produce. Good agricultural practices pertaining to food safety on farms and in local markets were seldom used. Adoption of food safety practices on-farm, during transport, and during marketing could improve the microbial quality of tomatoes available to the public in this region of the world.

title: Contamination of Tomatoes with Coliforms and XXXX on Farms and in Markets of Northwest Nigeria.

answer: @entity1


abstract: UNASSIGNED: The recurrence rate following the treatment of @entity4 ( @entity4 ) by primary surgery is about 10%-26%. The earliest possible diagnosis of @entity2 , recurrence of @entity2 , and subsequent @entity1 is essential for an improvement of the overall survival and of the survival period for affected @entity0 . No international consensus exists for a post-therapeutic surveillance schedule for OSCCs. Based on a review of the literature, existing guidelines, and our institutional experience, we have established an algorithm for the follow-up of these @entity0 regarding the timing and techniques of postoperative imaging. We recommend a follow-up interval of 6 weeks during the first half-year after discharge from hospital by single clinical and alternating clinical check-ups combined with computed tomography (CT) or magnetic resonance imaging (MRI), followed by an interval of 3 months in the second half-year, with clinical and radiological check-ups. In year 2, we recommend a follow-up interval of 3 months with single clinical and alternating clinical check-ups combined with CT or MRI. In year 3, we recommend screening every 6 months, both  clinically and via imaging, because of the decreased risk of recurrence. From year 5 onwards, our recommendation is a clinical and imaging-based examination every 6-12 months, depending on @entity0 risk factors and disease progression. Four standard imaging techniques, namely positron emission tomography (PET), CT, MRI, and ultrasound (US), are discussed concerning their range of application, sensitivity, and specificity. Furthermore, the technical aspects of our institutional protocols are described in detail. In highly frequented @entity3 centres, PET and US are of secondary importance, since CT and MRI are nowadays highly efficient tools in primary diagnostic and post-therapeutic surveillance.

title: Loco-regional recurrence after surgical treatment of XXXX : Proposals for follow-up imaging based on literature, national guidelines and institutional experience.

answer: @entity4


abstract: OBJECTIVE: To document the prevalence of @entity1 and foot @entity1 in @entity0 with @entity3 ( @entity2 ) and to examine its impact on health and function. METHODS: @entity0 from the Progression subcohort (n   =   1,255, ages 45-79 years) of the @entity2 Initiative with symptomatic tibiofemoral knee @entity2 were included. Prevalence of @entity1 , defined as @entity1 in the foot/ankle, and foot @entity1 were determined. Health status was evaluated using the Western Ontario and McMaster Universities @entity2 Index, the Short Form-12 Health Survey, and the Center for Epidemiological Studies Depression Scale. Function was assessed using the 20-meter @entity4 ( @entity4 ) and a repeated chair stand test. Differences in health and functional measures were compared between groups with and without @entity1 using multivariate analysis of covariance. RESULTS: One-fourth (n   =   317 [25%]) of @entity0 with knee @entity2 experienced concurrent @entity1 , with the majority (n   =   174 [55%]) reporting @entity1 in both feet. After adjusting for covariates, @entity0 with @entity1 scored worse on all health measures and on the 20-meter @entity4 , compared to those without (P   <   0.05). Differences in health and function were found between the bilateral and ipsilateral @entity1 groups compared to those without @entity1 (P   <   0.05), but no differences were found with the contralateral group. CONCLUSION: Foot @entity1 is common in @entity0 with knee @entity2 , and bilateral and ipsilateral @entity1 adversely affect health and function, suggesting laterality is important. Further research is needed to establish the mechanism and interaction of pathology at these sites and to evaluate @entity1 treatment in this population.

title: Impact of Concurrent Foot Pain on Health and Functional Status in @entity0 with Knee XXXX : Data From the @entity2 Initiative.

answer: @entity2


abstract: OBJECTIVE: To document the prevalence of @entity1 and foot @entity1 in @entity0 with @entity3 ( @entity2 ) and to examine its impact on health and function. METHODS: @entity0 from the Progression subcohort (n   =   1,255, ages 45-79 years) of the @entity2 Initiative with symptomatic tibiofemoral knee @entity2 were included. Prevalence of @entity1 , defined as @entity1 in the foot/ankle, and foot @entity1 were determined. Health status was evaluated using the Western Ontario and McMaster Universities @entity2 Index, the Short Form-12 Health Survey, and the Center for Epidemiological Studies Depression Scale. Function was assessed using the 20-meter @entity4 ( @entity4 ) and a repeated chair stand test. Differences in health and functional measures were compared between groups with and without @entity1 using multivariate analysis of covariance. RESULTS: One-fourth (n   =   317 [25%]) of @entity0 with knee @entity2 experienced concurrent @entity1 , with the majority (n   =   174 [55%]) reporting @entity1 in both feet. After adjusting for covariates, @entity0 with @entity1 scored worse on all health measures and on the 20-meter @entity4 , compared to those without (P   <   0.05). Differences in health and function were found between the bilateral and ipsilateral @entity1 groups compared to those without @entity1 (P   <   0.05), but no differences were found with the contralateral group. CONCLUSION: Foot @entity1 is common in @entity0 with knee @entity2 , and bilateral and ipsilateral @entity1 adversely affect health and function, suggesting laterality is important. Further research is needed to establish the mechanism and interaction of pathology at these sites and to evaluate @entity1 treatment in this population.

title: Impact of Concurrent Foot Pain on Health and Functional Status in @entity0 with Knee @entity2 : Data From the XXXX Initiative.

answer: @entity2


abstract: OBJECTIVE: To document the prevalence of @entity1 and foot @entity1 in @entity0 with @entity3 ( @entity2 ) and to examine its impact on health and function. METHODS: @entity0 from the Progression subcohort (n   =   1,255, ages 45-79 years) of the @entity2 Initiative with symptomatic tibiofemoral knee @entity2 were included. Prevalence of @entity1 , defined as @entity1 in the foot/ankle, and foot @entity1 were determined. Health status was evaluated using the Western Ontario and McMaster Universities @entity2 Index, the Short Form-12 Health Survey, and the Center for Epidemiological Studies Depression Scale. Function was assessed using the 20-meter @entity4 ( @entity4 ) and a repeated chair stand test. Differences in health and functional measures were compared between groups with and without @entity1 using multivariate analysis of covariance. RESULTS: One-fourth (n   =   317 [25%]) of @entity0 with knee @entity2 experienced concurrent @entity1 , with the majority (n   =   174 [55%]) reporting @entity1 in both feet. After adjusting for covariates, @entity0 with @entity1 scored worse on all health measures and on the 20-meter @entity4 , compared to those without (P   <   0.05). Differences in health and function were found between the bilateral and ipsilateral @entity1 groups compared to those without @entity1 (P   <   0.05), but no differences were found with the contralateral group. CONCLUSION: Foot @entity1 is common in @entity0 with knee @entity2 , and bilateral and ipsilateral @entity1 adversely affect health and function, suggesting laterality is important. Further research is needed to establish the mechanism and interaction of pathology at these sites and to evaluate @entity1 treatment in this population.

title: Impact of Concurrent Foot Pain on Health and Functional Status in XXXX with Knee @entity2 : Data From the @entity2 Initiative.

answer: @entity0


abstract: PURPOSE: To report clinical features and treatment outcomes of @entity4 ( @entity4 ). DESIGN: Retrospective case series. @entity0 : There were 32 @entity1 in 31 eyes of 30 @entity0 with @entity4 . METHODS: Review of medical records. MAIN OUTCOME MEASURES: Tumor control, intraocular pressure (IOP), and visual acuity. RESULTS: The mean @entity0 age at presentation was 51 months (median, 15 months; range, 1-443 months). Eye redness (12/30, 40%) and @entity3 (4/30, 13%) were the most common presenting symptoms. @entity4 was concurrently present in 3 @entity0 (3/30, 10%), and spinal @entity4 was present in 1 @entity0 (1/30, 3%). The ocular tissue affected by @entity4 included the @entity2 (21/31, 68%), conjunctiva (6/31, 19%), eyelid (2/31, 6%), choroid (2/31, 6%), and orbit (1/31, 3%). Those with @entity2 @entity4 presented at a median age of 13 months compared with 30 months for those with conjunctival @entity4 . In the @entity2 @entity4 group, mean IOP was 19 mmHg (median, 18 mmHg; range, 11-30 mmHg) and @entity3 was noted in 8 eyes (8/21, 38%). The @entity5 was nodular (16/21, 76%) or diffuse (5/21, 24%). Fine-needle aspiration biopsy was used in 10 cases and confirmed @entity4 cytologically in all cases. The @entity2 lesion was treated with topical (18/21, 86%) and/or periocular (4/21, 19%) corticosteroids. The eyelid, conjunctiva, and orbital @entity4 were treated with excisional biopsy in 5 @entity0 (5/9, 56%), topical corticosteroids in 2 @entity0 (2/9, 22%), and observation in 2 @entity0 (2/9, 22%). Of 28 @entity0 with a mean follow-up of 15 months (median, 6 months; range, 1-68 months), @entity1 regression was achieved in all cases, without recurrence. Two @entity0 were lost to follow-up. Upon follow-up of the @entity2 @entity4 group, visual acuity was stable or improved (18/19 @entity0 , 95%) and IOP was controlled long-term without medication (14/21 @entity0 , 74%). No eyes were managed with enucleation. CONCLUSIONS: Ocular @entity4 preferentially affects the @entity2 and is often isolated without cutaneous involvement. Iris @entity4 responds to topical or periocular corticosteroids, often with stabilization or improvement of vision and IOP.

title: Juvenile Xanthogranuloma Involving the Eye and Ocular Adnexa: Tumor Control, Visual Outcomes, and Globe Salvage in 30  XXXX .

answer: @entity0


abstract: OBJECTIVE: @entity0 are at risk for @entity4 following attendance at colposcopy for cervical abnormalities, with potentially negative consequences. Little is presently known about the correlates of post-colposcopy distress. The present study aimed to extend knowledge of correlates of post-colposcopy @entity1 and negative affect, and identify @entity0 at risk for elevated @entity3 . METHODS: Psychosocial data (demographic variables, @entity1 , negative affect, and @entity2 ) were collected using validated questionnaires from 164 @entity0 attending colposcopy for the first time immediately prior to their colposcopy examination and immediately following it. Two separate logistic regressions were conducted to identify key factors that may be useful targets for preventing post-colposcopy distress and to determine which factors exert the biggest influence and therefore may be targeted in future intervention studies. RESULTS: Pre-colposcopy state @entity1 , @entity2 experienced during colposcopy, and trait @entity1 emerged as independent predictors of post-colposcopy state @entity1 , accounting for 36% of the variance. Pre-colposcopy negative affect, @entity2 experienced during colposcopy, trait @entity1 , and referral smear grade were independent predictors of post-colposcopy negative affect, explaining 32% of variance. CONCLUSIONS: Whether or not @entity0 underwent punch biopsy or treatment did not influence post-colposcopy distress levels; however, @entity2 experienced during colposcopy remains a risk for continued @entity3 . Trait @entity1 may be an important variable to consider in future studies, as @entity0 high in trait @entity1 may represent a particularly vulnerable subgroup of @entity0 referred for colposcopy, at greater risk for negative psychosocial consequences associated with colposcopy, and to be targeted for interventions to reduce @entity3 . Copyright    2015 John Wiley _ Sons, Ltd.

title: Correlates of XXXX immediately following colposcopy.

answer: @entity3


abstract: BACKGROUND: @entity2 ( @entity2 ) is a chronic inflammatory and immune-mediated disease. @entity3 is one of the most extensively studied Wnt proteins, and has important functions in stimulating @entity1 , cell proliferation, cell fate determination and cell differentiation. @entity3 expression in @entity2 has not been comprehensively studied to date. AIM: To determine the expression and distribution of @entity3 in @entity2 . METHODS: Skin samples were obtained from @entity0 with @entity2 and healthy controls (HCs). The @entity3 gene was detected by real-time quantitative PCR, and @entity3 protein by immunohistochemical analysis and western blotting. RESULTS: @entity3 mRNA was upregulated in @entity2 samples compared with the HC skin samples (P  <  0.001). @entity3 protein was overexpressed in all layers of the epidermis and dermis in @entity2 compared with HC skin (all P  <  0.001). These results were confirmed by western blotting. CONCLUSIONS: The data presented in this study suggest that @entity3 pathway may play an important role in the pathogenesis of @entity2 .

title: XXXX is involved in the pathogenesis of cutaneous lichen planus.

answer: @entity3


abstract: This study aimed to investigate the anti-angiogenic effects of @entity7 on the expression of @entity4 ( @entity4 ) and @entity2 -inducible transcription factor 1a ( @entity5 ) in a @entity0 model for @entity1 -induced @entity3 (OIR). The OIR @entity0 were exposed to 75% @entity1 from postnatal day 7 (P7) to @entity9 , after which the @entity0 were randomly assigned to two groups ( @entity7 and vehicle) and were brought to room air for additional five days. @entity7 or vehicle was administered from @entity9 to @entity8 . Age-matched @entity0 maintained in room air from birth to @entity8 were administered vehicle from @entity9 to @entity8 (RA group). Blood vessel profiles in the retina were used to count by histologic methods. Retina protein and mRNA of @entity4 and @entity5 were assessed by immunohistochemistry, western-blot and RT-PCR. Compared with the RA group, the OIR @entity0 exhibited over-expression in @entity4 and @entity5 mRNA and protein. In addition, they had a positive and spatial correlation. @entity7 - treated OIR @entity0 reduced the @entity6 and the levels of @entity4 and @entity5 . These data suggest that @entity7 inhibits retinal pathogenic angiogenesis through down-regulating @entity5 expression which suppressing @entity4 transcription. @entity7 could potentially serve as a portent pharmaceutical agent to inhibit retinal angiogenesis.

title: XXXX attenuates retinal angiogenesis in a @entity0 model of @entity1 -induced @entity3 .

answer: @entity7


abstract: This study aimed to investigate the anti-angiogenic effects of @entity7 on the expression of @entity4 ( @entity4 ) and @entity2 -inducible transcription factor 1a ( @entity5 ) in a @entity0 model for @entity1 -induced @entity3 (OIR). The OIR @entity0 were exposed to 75% @entity1 from postnatal day 7 (P7) to @entity9 , after which the @entity0 were randomly assigned to two groups ( @entity7 and vehicle) and were brought to room air for additional five days. @entity7 or vehicle was administered from @entity9 to @entity8 . Age-matched @entity0 maintained in room air from birth to @entity8 were administered vehicle from @entity9 to @entity8 (RA group). Blood vessel profiles in the retina were used to count by histologic methods. Retina protein and mRNA of @entity4 and @entity5 were assessed by immunohistochemistry, western-blot and RT-PCR. Compared with the RA group, the OIR @entity0 exhibited over-expression in @entity4 and @entity5 mRNA and protein. In addition, they had a positive and spatial correlation. @entity7 - treated OIR @entity0 reduced the @entity6 and the levels of @entity4 and @entity5 . These data suggest that @entity7 inhibits retinal pathogenic angiogenesis through down-regulating @entity5 expression which suppressing @entity4 transcription. @entity7 could potentially serve as a portent pharmaceutical agent to inhibit retinal angiogenesis.

title: @entity7 attenuates retinal angiogenesis in a @entity0 model of XXXX -induced @entity3 .

answer: @entity1


abstract: This study aimed to investigate the anti-angiogenic effects of @entity7 on the expression of @entity4 ( @entity4 ) and @entity2 -inducible transcription factor 1a ( @entity5 ) in a @entity0 model for @entity1 -induced @entity3 (OIR). The OIR @entity0 were exposed to 75% @entity1 from postnatal day 7 (P7) to @entity9 , after which the @entity0 were randomly assigned to two groups ( @entity7 and vehicle) and were brought to room air for additional five days. @entity7 or vehicle was administered from @entity9 to @entity8 . Age-matched @entity0 maintained in room air from birth to @entity8 were administered vehicle from @entity9 to @entity8 (RA group). Blood vessel profiles in the retina were used to count by histologic methods. Retina protein and mRNA of @entity4 and @entity5 were assessed by immunohistochemistry, western-blot and RT-PCR. Compared with the RA group, the OIR @entity0 exhibited over-expression in @entity4 and @entity5 mRNA and protein. In addition, they had a positive and spatial correlation. @entity7 - treated OIR @entity0 reduced the @entity6 and the levels of @entity4 and @entity5 . These data suggest that @entity7 inhibits retinal pathogenic angiogenesis through down-regulating @entity5 expression which suppressing @entity4 transcription. @entity7 could potentially serve as a portent pharmaceutical agent to inhibit retinal angiogenesis.

title: @entity7 attenuates retinal angiogenesis in a @entity0 model of @entity1 -induced XXXX .

answer: @entity3


abstract: This study aimed to investigate the anti-angiogenic effects of @entity7 on the expression of @entity4 ( @entity4 ) and @entity2 -inducible transcription factor 1a ( @entity5 ) in a @entity0 model for @entity1 -induced @entity3 (OIR). The OIR @entity0 were exposed to 75% @entity1 from postnatal day 7 (P7) to @entity9 , after which the @entity0 were randomly assigned to two groups ( @entity7 and vehicle) and were brought to room air for additional five days. @entity7 or vehicle was administered from @entity9 to @entity8 . Age-matched @entity0 maintained in room air from birth to @entity8 were administered vehicle from @entity9 to @entity8 (RA group). Blood vessel profiles in the retina were used to count by histologic methods. Retina protein and mRNA of @entity4 and @entity5 were assessed by immunohistochemistry, western-blot and RT-PCR. Compared with the RA group, the OIR @entity0 exhibited over-expression in @entity4 and @entity5 mRNA and protein. In addition, they had a positive and spatial correlation. @entity7 - treated OIR @entity0 reduced the @entity6 and the levels of @entity4 and @entity5 . These data suggest that @entity7 inhibits retinal pathogenic angiogenesis through down-regulating @entity5 expression which suppressing @entity4 transcription. @entity7 could potentially serve as a portent pharmaceutical agent to inhibit retinal angiogenesis.

title: @entity7 attenuates retinal angiogenesis in a XXXX model of @entity1 -induced @entity3 .

answer: @entity0


abstract: @entity4 is a syndrome that can be caused by a variety of abnormalities, including pressure and @entity6 , loss of muscle, primary @entity2 or excessive peripheral demands such as high output failure. In the usual form of @entity4 , the heart muscle has reduced contractility. This produces a reduction in cardiac output, which then becomes inadequate to meet the peripheral demands of the body. The 4 primary determinants of left ventricular (LV) performance are generally altered as follows: (1) There is an intrinsic decrease in muscle contractility. (2) Preload or left atrial filling pressure is increased, resulting in @entity5 and @entity7 . (3) Although systemic blood pressure is often reduced, there is an increase in systemic vascular resistance (afterload), which can further reduce cardiac output. (4) Heart rate is generally increased as part of a compensatory mechanism associated with an increase in sympathetic tone and circulating @entity8 . In @entity0 with @entity3 , there is often an imbalance between myocardial @entity1 supply and demand. An increase in heart size may be particularly deleterious by increasing wall tension because of the Laplace relation and increasing myocardial @entity1 consumption.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Pathophysiology of XXXX .

answer: @entity4


abstract: Prevention of @entity4 continues to concern health care providers in many specialties. The well-known lack of primary clinical trials in this area is not expected to change. Therefore, the evolution of recommendations and practice must be based on theoretic considerations and continuing assessment of secondary sources of information. Recent developments include a report of 52 cases in which antibiotic prophylaxis for @entity4 was attempted but appeared to fail. Most of these @entity0 had undergone dental procedures after oral @entity1 prophylaxis, with subsequent development of @entity3 . In two thirds, the organism was sensitive to the antibiotic used. Notably, the most common underlying @entity2 among these @entity0 was @entity6 . However, two recent independent analyses have concluded that providing @entity4 prophylaxis for all @entity0 with @entity6 during procedures that might cause @entity5 would not be cost-effective. This is primarily because @entity6 is common and @entity4 is relatively rare, resulting in an adverse risk-benefit ratio. Parenteral prophylaxis for @entity6 might even cause a net loss of life from anaphylaxis. On the other hand, for the individual @entity0 or physician, the reassurance provided by attempted prophylaxis with oral @entity1 can be purchased at low cost and low risk. Very few cases of @entity4 have been reported after gastrointestinal and other endoscopic procedures; most of these do not need antibiotic coverage. Prophylactic antibiotics should be restricted to those situations in which both the procedure and the underlying cardiac condition seem to pose significant risk, for example, endoscopic sclerotherapy of esophageal varices in @entity0 with prosthetic heart valves. Newly revised recommendations have been issued by the Medical Letter, the American Heart Association, and the American Dental Association. These regimens are shorter and simpler than earlier versions.

title: Current issues in prevention of XXXX .

answer: @entity4


abstract: We assessed the effects of eye rubbing on the histologic characteristics and inflammatory cell infiltrate of the conjunctiva. The upper eyelids of 20 adult @entity1 were rubbed during a five-minute period, and then the animals were killed immediately, or at four, eight, or 24 hours after @entity2 . One eye of each animal was rubbed; the unrubbed contralateral eye served as a control. Counts of mast cells, degranulated mast cells, and inflammatory cells (neutrophils, eosinophils, lymphocytes, plasma cells, and macrophages) were recorded from conjunctival samples from the upper eyelid. Immediately after eye rubbing the conjunctival epithelium was histologically disrupted and 50% of the mast cells showed evidence of degranulation. At four hours after @entity2 the increase in the number of neutrophils was more than 2,300%. Neutrophils were in the margins in the conjunctival vessels, had migrated into the substantia propria, and were aligned subjacent to the epithelial basement membrane; large numbers of neutrophils populated the epithelium. The four-hour stage was the most dramatic phase of @entity0 that occurred from the eye rubbing. At 24 hours there was a significant increase in the number of macrophages. The numbers of lymphocytes, plasma cells, and eosinophils were not significantly changed throughout the study. Our findings demonstrate that eye rubbing histologically disrupts the epithelium and induces significant alteration in the inflammatory cell infiltrate of the conjunctiva. These changes may influence the course of @entity3 .

title: Effects of eye rubbing on the conjunctiva as a model of XXXX .

answer: @entity0


abstract: Study Objectives: We tested whether providing adults with @entity1 ( @entity1 ) with daily Web-based access to their positive airway pressure ( @entity2 ) usage over 3 mo with or without a financial incentive in the first week improves adherence and functional outcomes. Setting: Academic- and community-based sleep centers. @entity0 : One hundred thirty-eight adults with newly diagnosed @entity1 starting @entity2 treatment. Interventions: @entity0 were randomized to: usual care, usual care with access to @entity2 usage, or usual care with access to @entity2 usage and a financial incentive. @entity2 data were transmitted daily by wireless modem from the @entity0 ' @entity2 unit to a website where hours of usage were displayed. @entity0 in the financial incentive group could earn up to  30/day in the first week for objective @entity2 use >=  4 h/day. Measurements and Results: Mean hours of daily @entity2 use in the two groups with access to @entity2 usage data did not differ from each other but was significantly greater than that in the usual care group in the first week and over 3 mo (P < 0.0001). Average daily use (mean    standard deviation) during the first week of @entity2 intervention was 4.7    3.3 h in the usual care group, and 5.9    2.5 h and 6.3    2.5 h in the Web access groups with and without financial incentive respectively. Adherence over the 3-mo intervention decreased at a relatively constant rate in all three groups. Functional Outcomes of Sleep Questionnaire change scores at 3 mo improved within each group (P < 0.0001) but change scores of the two groups with Web access to @entity2 data were not different than those in the control group (P > 0.124). Conclusions: @entity2 adherence is significantly improved by giving @entity0 Web access to information about their use of the treatment. Inclusion of a financial incentive in the first week had no additive effect in improving adherence.

title: Web-Based Access to Positive Airway Pressure Usage with or without an Initial Financial Incentive Improves Treatment Use in XXXX with Obstructive Sleep Apnea.

answer: @entity0


abstract: BACKGROUND: The aim of this retrospective study was to evaluate the peri-operative and long-term outcome after early repair with a hepaticojejunostomy (HJ). METHODS: Between 1995 and 2010, a nationwide, retrospective multi-centre study was conducted. All iatrogenic @entity2 ( @entity2 ) sustained during a cholecystectomy and repaired with HJ in the five Hepato-Pancreatico-Biliary centres in Denmark were included. RESULTS: In total, 139 @entity0 had an HJ repair. The median time from the @entity2 to reconstruction was 5 days. A concomitant @entity3 was identified in 26 cases (19%). Post-operative morbidity was 36% and mortality was 4%. Forty-two @entity0 (30%) had a @entity1 of the HJ. The median follow-up time without @entity1 was 102 months. Nineteen out of the 42 @entity0 with post-reconstruction biliary strictures had a re-HJ. Twenty-three @entity0 were managed with percutaneous transhepatic cholangiography and dilation. The overall success rate of re-establishing the biliodigestive flow approached 93%. No association was found between timing of repair, concomitant @entity3 , level of injury and @entity1 formation. CONCLUSION: In this national, unselected and consecutive cohort of @entity0 with @entity2 repaired by early HJ we found a considerable risk of long-term complications (e.g. 30% @entity1 rate) and mortality in both the short- and the long-term perspective.

title: Long-term outcome after early repair of iatrogenic XXXX . A national Danish multicentre study.

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to retrospectively evaluate the intensive care unit treatments applied to obstetrics @entity0 with a diagnosis of @entity2 ( @entity2 ). MATERIAL AND METHODS: The cases of 7 pregnant @entity0 who had been diagnosed with @entity2 between July 2011 and July 2013 were retrospectively reviewed. The @entity0 ' clinical data, brain magnetic resonance imaging (MRI) images before and after treatment, and neuropsychological tests were evaluated. RESULTS: Five out of 7 @entity0 had @entity10 , 1 @entity0 had severe @entity7 , and 1 @entity0 developed @entity8 secondary to @entity2 . @entity5 channel blockers and b-blockers were used as antihypertensive treatment. All @entity0 were treated with parenteral @entity9 . In addition, @entity6 thiopental was given to control sedation and @entity4 in all @entity0 except 1. The neurological and radiological findings of all cases treated in the intensive care unit improved. CONCLUSION: Posterior reversible @entity2 syndrome is a clinical condition with a multifactorial etiology and can result in different clinical findings. Radiological imaging techniques can be used for the diagnosis of @entity2 . Pregnancy and the postpartum period often lead to this syndrome. In some cases, @entity2 can cause irreversible @entity1 or @entity3 . For @entity0 with severe radiological findings, early diagnosis and thiopental infusion, in addition to treatment with antihypertensive agents and @entity9 , may lead to quicker and more effective recovery from clinical manifestations. We suggest supplementation of standard treatment with early thiopental infusion.

title: An intensive care approach to @entity2 ( XXXX ): An analysis of 7 cases.

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to retrospectively evaluate the intensive care unit treatments applied to obstetrics @entity0 with a diagnosis of @entity2 ( @entity2 ). MATERIAL AND METHODS: The cases of 7 pregnant @entity0 who had been diagnosed with @entity2 between July 2011 and July 2013 were retrospectively reviewed. The @entity0 ' clinical data, brain magnetic resonance imaging (MRI) images before and after treatment, and neuropsychological tests were evaluated. RESULTS: Five out of 7 @entity0 had @entity10 , 1 @entity0 had severe @entity7 , and 1 @entity0 developed @entity8 secondary to @entity2 . @entity5 channel blockers and b-blockers were used as antihypertensive treatment. All @entity0 were treated with parenteral @entity9 . In addition, @entity6 thiopental was given to control sedation and @entity4 in all @entity0 except 1. The neurological and radiological findings of all cases treated in the intensive care unit improved. CONCLUSION: Posterior reversible @entity2 syndrome is a clinical condition with a multifactorial etiology and can result in different clinical findings. Radiological imaging techniques can be used for the diagnosis of @entity2 . Pregnancy and the postpartum period often lead to this syndrome. In some cases, @entity2 can cause irreversible @entity1 or @entity3 . For @entity0 with severe radiological findings, early diagnosis and thiopental infusion, in addition to treatment with antihypertensive agents and @entity9 , may lead to quicker and more effective recovery from clinical manifestations. We suggest supplementation of standard treatment with early thiopental infusion.

title: An intensive care approach to XXXX ( @entity2 ): An analysis of 7 cases.

answer: @entity2


abstract: @entity4 usually occurs between 20-50 years of age, comprising about 5-10% of soft tissue @entity1 . Only 1.7% of them have been reported to occur in @entity0 < 5 months of age according to the literature. Here, we are describing 18 mnth old male @entity0 presented with a swelling in the lower back. MRI showed a sacrcoccygeal swelling extending to and communicating with CSF at lower sacral level. Birth history of the @entity0 was normal with normal apgar score. The histological diagnosis was @entity4 . IHC showed focal positivity of @entity2 and @entity5 . Primary spinal @entity3 in @entity0 are rarer. A careful neurological examination is warranted in @entity0 . Early diagnosis and referral to multidisciplinary team are important in ensuring the best diagnosis and optimal therapy in this young age.

title: Primary XXXX in Childhood- A Rare Case Report.

answer: @entity3


abstract: Extra- adrenal retroperitoneal @entity8 are @entity6 with an incidence of 2-8 per million. They arise from embryonic neural crest cells and are composed mainly of chromaffin cells located in the para- aortic sympathetic chain. They synthesize, store and secrete catecholamines because of which they may present with @entity2 , sweating, palpitation and symptoms of @entity3 . On the other hand, they may remain silent and non- functional and present with vague symptoms like @entity4 abdomen due to episodic release of catecholamines. Histologically and immunohistochemically, non- functional and the functional @entity1 are no different from each other. Primary methods of pre-operative diagnosis include imaging techniques which also help in surgical planning and pre-operative preparation. @entity1 of ten escape pre-operative detection and create per- operative complications. We present a case of non- functional @entity9 occurring in a 66-year-old female @entity0 presenting with @entity4 and mass per abdomen. On ultrasonongraphy, a retroperitoneal mass of probable mesenchymal origin was suspected. The @entity0 was posted for surgical resection of the mass. Per-operatively, the @entity0 developed @entity3 crisis and @entity7 . Post-operatively she developed @entity5 and succumbed to it after three days. This report highlights the importance of pre- operative diagnosis which is vital in the management of @entity9 .

title: Extra- adrenal silent retroperitoneal XXXX : report of a rare case.

answer: @entity8


abstract: OBJECTIVE: To identify the impact of smoking intensity on @entity1 characteristics at the time of initial @entity2 diagnosis. METHODS: We retrospectively reviewed our institution's prospective database of @entity0 diagnosed with @entity2 from 1987 to 2009. Only @entity0 with @entity5 and recorded @entity3 history were included. @entity0 were stratified by @entity3 history into nonsmokers, light smokers ( <=30 pack-years), and heavy smokers (>30 pack-years). An additional analysis was performed looking at @entity0 meeting National Lung Cancer Screening Trial (NLCST) criteria (55- to 74-year-old @entity0 with  >= 30 pack-years smoking history and  <15  years since smoking cessation). Clinicopathologic characteristics of the initial @entity2 at time of diagnosis were analyzed. RESULTS: We identified 197 (26.6%) nonsmokers, 251 (33.9%) light smokers, and 292 (39.5%) heavy smokers. Males were more likely to be heavy smokers (44.5% vs 23.6%, P   <=.01). Compared with nonsmokers and light smokers, the @entity1 in heavy smokers were more likely to be high grade with a more advanced clinical stage. Heavy smokers were more likely to present with muscle-invasive @entity2 (MIBC) at initial diagnosis. When compared to nonsmokers, the odds ratio for presenting with MIBC was 1.18 (95% confidence interval  = 0.68-2.1) for light smokers and 1.38 (95% confidence interval  = 1.06-1.8) for heavy smokers. Of 793 @entity0 with adequate information for analysis, 184 (23.2%) met NLCST criteria. Those meeting NLCST criteria were most likely to be male, to present with gross @entity4 , and to have @entity1 that were high grade and muscle invasive. NLCST criteria eligibility remained associated with MIBC on multivariate analysis. CONCLUSION: Heavy smokers and @entity0 meeting NLCST criteria are more likely to have high-grade @entity1 with detrusor muscle invasion at initial presentation.

title: Heavy Cigarette Smoking and Aggressive XXXX at Initial Presentation.

answer: @entity2


abstract: BACKGROUND: A recent study indicated the efficacy of the addition of @entity2 to intravenous immunoglobulin (IVIG) as initial treatment in @entity0 with higher risk of IVIG resistance. Several different risk scores for predicting IVIG resistance have been proposed mainly based on typical @entity1 ( @entity1 ) @entity0 . We investigated the utility of the risk scores to predict IVIG resistance with incomplete @entity1 . METHODS: Clinical records of incomplete @entity1 @entity0 who received a single dose of IVIG between 2005 and 2012 at our institute were retrospectively reviewed. @entity0 were classified into an IVIG-responsive group and an IVIG-resistant group. The Kobayashi, Egami, and Sano risk scores were calculated for each @entity0 and the proportion of high-risk @entity0 was compared between the two groups for each risk score. RESULTS: For 51 incomplete @entity1 @entity0 , Kobayashi (66.7% versus 47.6%, P   =   0.253), Egami (55.6% versus 38.1%, P   =   0.274), and Sano (57.1% versus 10.8%, P   =   0.068) risk scores identified a higher proportion of high-risk @entity0 in the IVIG-resistant group compared to the IVIG-responsive group, but significant difference was not observed. The Sano risk score showed the highest odds ratio (6.19, 95% confidence interval 1.00-38.26). CONCLUSIONS: The proportion of @entity0 identified as being at high-risk for IVIG resistance using the Kobayashi, Egami, and Sano risk scores, respectively, were not significantly different between the IVIG-responsive group and the IVIG-resistant group with incomplete @entity1 . Among the three risk scores, the Sano risk score has the best ability to predict IVIG resistance with incomplete @entity1 . This article is protected by copyright. All rights reserved.

title: Verification of risk scores to predict intravenous immunoglobulin resistance in incomplete XXXX .

answer: @entity1