abstract: BACKGROUND: In 2009 the American Society for Gastrointestinal Endoscopy (ASGE) guidelines advised that both @entity1 and NSAIDs be continued prior to low-risk gastrointestinal endoscopic procedures. We sought to determine physician knowledge regarding these guidelines. METHODS: A survey questionnaire was developed based on the ASGE guidelines. Physicians were queried about whether they would continue/stop @entity1 in a @entity0 with @entity2 and in a @entity0 taking NSAIDs for @entity3 whether they would continue/stop NSAIDs prior to endoscopy. The survey was administered at three academic medical centers. Demographic information: level of training, board certification, teaching trainees, percentage of time in clinical practice, year of medical school graduation, and location of medical school were all reviewed. The primary outcome was number of questions answered correctly and predictors of correct responses. RESULTS: The survey was administered to 941 @entity0 with 12 declining to participate, while 80  % (740/929) of the subjects completed the survey; 20  % (150/740) respondents answered both questions correctly and 42  % (310/740) answered one question correctly. There was no significant difference between institutions (p  =  0.6) or between attendings and trainees (p  =  0.75). Multivariate predictors of correct answers were self-reported familiarity with the guideline (-0.029; 95  % CI -0.003 to -0.056, p  <  0.031), level of training (0.050; 95  % CI 0.012-0.088, p  =  0.010), and specialty (0.108; 95  % CI 0.058-0.159, p  <  0.0001). Finally, there was an inverse, linear relationship between postgraduate year and percent questions correct. CONCLUSION: Physician knowledge of guidelines regarding the use of @entity1 and NSAIDs prior to endoscopy is suboptimal. Interventions are necessary to improve knowledge of the current pre-procedure guidelines.

title: Multicenter Study Assessing Physician Recommendations Regarding the Continuation of XXXX and/or NSAIDs Prior to Gastrointestinal Endoscopy.

answer: @entity1


abstract: OBJECTIVES: The aim of this study was to assess the impact of ticagrelor dosing regimens on pharmacodynamic (PD) profiles in @entity0 on maintenance ticagrelor therapy. BACKGROUND: Many @entity0 on maintenance @entity6 -inhibiting therapies may require coronary revascularization procedures, raising a common clinical question with regard to the dosing regimen of the @entity6 -inhibiting agent to be used. To date, investigations assessing dosing regimens of @entity6 receptor inhibitors in @entity0 on maintenance therapy have been only assessed with @entity5 , but not with ticagrelor. METHODS: This was a prospective, randomized, double-blind, placebo-controlled study assessing the PD effects of 2  dosing regimens of ticagrelor in @entity0 on standard @entity2 and ticagrelor maintenance therapy. A total of 60 @entity0 were randomized to either 90 mg ( @entity1 [ @entity1 ] group) or 180 mg (loading dose [LD] group) dose of ticagrelor. PD assessments were conducted at 3 time points (baseline, 1 h and 4 h). PD assessments were defined according to the platelet reactivity index (PRI) (vasodilator-stimulated phosphoprotein phosphorylation assay), @entity6 reaction unit  (VerifyNow @entity6 assay) and @entity3 -induced @entity4 by light transmittance aggregometry. RESULTS: There were no differences in baseline levels of platelet reactivity with all assays. Intergroup comparisons by means of repeated-measures analysis adjusted for baseline PRI values showed that the LD group had significantly lower  PRI levels compared with the @entity1 group during the overall study time course (p  = 0.031). Consistent findings were  found for @entity6 reaction unit (p  = 0.026) and light transmittance aggregometry (p  = 0.004). Intragroup comparisons showed that a more prompt and sustained platelet inhibitory effect was achieved more consistently with an LD regimen compared with a @entity1 regimen. CONCLUSIONS: In @entity0 on maintenance ticagrelor therapy, a 180-mg LD regimen of @entity7 is associated with more potent and prompt platelet inhibition compared with a 90-mg @entity1 . (Impact of Ticagrelor Re-Load Pharmacodynamic Profiles; NCT01731041).

title: Pharmacodynamic Effects of Ticagrelor Dosing Regimens in XXXX on Maintenance Ticagrelor Therapy: Results From a Prospective, Randomized, Double-Blind Investigation.

answer: @entity0


abstract: UNASSIGNED: Rituximab induces @entity3 ( @entity3 ) remission in two-thirds of @entity0 with primary @entity1 ( @entity1 ), even after other treatments have failed. To assess the relationships among treatment effect, circulating nephritogenic anti- @entity4 receptor (anti- @entity5 ) autoantibodies and genetic polymorphisms predisposing to antibody production we serially monitored 24-hour @entity2 and antibody titer in @entity0 with primary @entity1 and long-lasting @entity3 consenting to rituximab (375 mg/m(2)) therapy and genetic analyses. Over a median (range) follow-up of 30.8 (6.0-145.4) months, 84 of 132 rituximab-treated @entity0 achieved complete or partial @entity3 remission (primary end point), and 25 relapsed after remission. Outcomes of @entity0 with or without detectable anti- @entity5 antibodies at baseline were similar. Among the 81 patients with antibodies, lower anti- @entity5 antibody titer at baseline (P=0.001) and full antibody depletion 6 months post-rituximab (hazard ratio [HR], 7.90; 95% confidence interval [95% CI], 2.54 to 24.60; P<0.001) strongly predicted remission. All 25 complete remissions were preceded by complete anti- @entity5 antibody depletion. On average, 50% anti- @entity5 titer reduction preceded equivalent @entity2 reduction by 10 months. Re-emergence of circulating antibodies predicted disease relapse (HR, 6.54; 95% CI, 1.57 to 27.40; P=0.01), whereas initial complete remission protected from the event (HR, 6.63; 95% CI, 2.37 to 18.53; P<0.001). Eighteen @entity0 achieved persistent antibody depletion and complete remission and never relapsed. Outcome was independent of @entity5 and @entity6 polymorphisms and of previous immunosuppressive treatment. Therefore, assessing circulating anti- @entity5 autoantibodies and @entity2 may help in monitoring disease activity and guiding personalized rituximab therapy in @entity3 @entity0 with primary @entity1 .

title: Anti- @entity4 Receptor Antibody Titer Predicts Post-Rituximab Outcome of XXXX .

answer: @entity1


abstract: UNASSIGNED: Rituximab induces @entity3 ( @entity3 ) remission in two-thirds of @entity0 with primary @entity1 ( @entity1 ), even after other treatments have failed. To assess the relationships among treatment effect, circulating nephritogenic anti- @entity4 receptor (anti- @entity5 ) autoantibodies and genetic polymorphisms predisposing to antibody production we serially monitored 24-hour @entity2 and antibody titer in @entity0 with primary @entity1 and long-lasting @entity3 consenting to rituximab (375 mg/m(2)) therapy and genetic analyses. Over a median (range) follow-up of 30.8 (6.0-145.4) months, 84 of 132 rituximab-treated @entity0 achieved complete or partial @entity3 remission (primary end point), and 25 relapsed after remission. Outcomes of @entity0 with or without detectable anti- @entity5 antibodies at baseline were similar. Among the 81 patients with antibodies, lower anti- @entity5 antibody titer at baseline (P=0.001) and full antibody depletion 6 months post-rituximab (hazard ratio [HR], 7.90; 95% confidence interval [95% CI], 2.54 to 24.60; P<0.001) strongly predicted remission. All 25 complete remissions were preceded by complete anti- @entity5 antibody depletion. On average, 50% anti- @entity5 titer reduction preceded equivalent @entity2 reduction by 10 months. Re-emergence of circulating antibodies predicted disease relapse (HR, 6.54; 95% CI, 1.57 to 27.40; P=0.01), whereas initial complete remission protected from the event (HR, 6.63; 95% CI, 2.37 to 18.53; P<0.001). Eighteen @entity0 achieved persistent antibody depletion and complete remission and never relapsed. Outcome was independent of @entity5 and @entity6 polymorphisms and of previous immunosuppressive treatment. Therefore, assessing circulating anti- @entity5 autoantibodies and @entity2 may help in monitoring disease activity and guiding personalized rituximab therapy in @entity3 @entity0 with primary @entity1 .

title: Anti- XXXX Receptor Antibody Titer Predicts Post-Rituximab Outcome of @entity1 .

answer: @entity4


abstract: BACKGROUND: Growing evidence suggests that the heart rate (HR) at rest is an independent predictor of @entity1 . In @entity4 , continuous monitoring of HR is the standard of care, but systematic data on its dynamics and prognostic value during the acute phase are limited. METHODS: In this prospective observational study, HR was measured by continuous electrocardiographic monitoring on admission and during the first 72  hours of care among @entity0 who were awake with @entity4 and survived until discharge. Functional outcome was assessed after 90  days. RESULTS: Data from 702 consecutive @entity0 were analyzed (median age, 73  years, 54% @entity0 ). The time course of HR was initially characterized by a rapid decline during the first 12  hours after admission. Among @entity0 who survived until day 90, this was followed by a continuous downward trend in HR, whereas @entity2 after discharge was associated with a secondary increase and a reversal point 12  hours after admission. After adjustment for established risk factors, this secondary increase during the acute period was an independent predictor of @entity2 (hazard ratio, 3.73; 95% confidence interval, 1.47-9.43; P  =  .005). CONCLUSIONS: A secondary rise of HR during care for acute @entity4 is an early  sign of fatality and may represent a surrogate for an unfavorable sympathetic disinhibition. Further research is warranted to clarify the role of targeted @entity3 after  @entity4 (http://clinicaltrials.gov/, unique identifier NCT01858779).

title: Impact of Heart Rate Dynamics on Mortality in the Early Phase after XXXX : A Prospective Observational Trial.

answer: @entity4


abstract: UNASSIGNED: The goal of this study was to attempt to determine the rate of contamination of health-care workers' (HCWs) hands and environmental surfaces in intensive care units (ICU) by the main bacteria associated with hospital acquired @entity2 (HAIs) in Tehran, Iran. A total of 605 and 762 swab samples were obtained from six ICU environments and HCWs' hands. Identification of the bacterial isolates was performed according to standard biochemical methods, and their antimicrobial susceptibility was determined based on the guidelines recommended by clinical and laboratory standards institute (CLSI). The homology of the resistance patterns was assessed by the NTSYSsp software. The most frequent bacteria on the HCWs' hands and in the environmental samples were @entity5 (1.4% and 16.5%, respectively), @entity3 (5.9% and 8.1%, respectively), @entity7 (20.9% and 18.7%, respectively), and Enterococcus spp. (1% and 1.3%, respectively). @entity0 ' @entity1 masks, ventilators, and bed linens were the most contaminated sites. Nurses' aides and housekeepers were the most contaminated staff. Imipenem resistant A. baumannii (94% and 54.5%), @entity6 -resistant @entity3 (MRSAs, 59.6% and 67.3%), and @entity4 resistant Enterococci (VREs, 0% and 25%) were detected on the hands of ICU staff and the environmental samples, respectively. Different isolates of @entity3 and Enterococcus spp. showed significant homology in these samples. These results showed contamination of the ICU environments and HCWs with important bacterial pathogens that are the main risk factors for HAIs in the studied hospitals.

title: The role of the intensive care unit environment and health-care workers in the transmission of bacteria associated with hospital acquired XXXX .

answer: @entity2


abstract: UNASSIGNED: @entity7 ( @entity7 ) is a rare soft tissue @entity1 of intermediate biologic potential and uncertain differentiation, most often arising in the extremities of @entity0 and young adults. Although it has characteristic histologic features of a lymphoid cuff surrounding nodules of ovoid cells with blood-filled cystic cavities, diagnosis is often difficult due to its morphologic heterogeneity and lack of specific immunoprofile. @entity7 is associated with recurrent chromosomal translocations, leading to characteristic @entity4 - @entity2 , @entity4 - @entity3 , and, rarely, @entity6 gene fusions; fluorescence in situ hybridization (FISH), detecting @entity4 or @entity5 rearrangements, and reverse transcription-polymerase chain reaction (RT-PCR) for @entity4 - @entity2 and @entity4 - @entity3 fusion transcripts have become routine ancillary tools. We present a large comparative series of FISH and RT-PCR for @entity7 . Seventeen @entity1 (from 16 @entity0 ) histologically diagnosed as @entity7 were assessed for @entity4 rearrangements or @entity4 - @entity2 and @entity4 - @entity3 fusion transcripts. All 17 were positive for either FISH or RT-PCR or both. Of 16, 14 (87.5%) had detectable @entity4 - @entity2 or @entity4 - @entity3 fusion transcripts by RT-PCR, whereas 13 (76.5%) of 17 had positive @entity4 rearrangement with FISH. All 13 of 13 non- @entity7 control @entity1 failed to show @entity4 - @entity2 or @entity4 - @entity3 fusion transcripts, whereas @entity4 rearrangement was present in 2 of these 13 cases (which were @entity1 ). This study shows that @entity4 - @entity2 or @entity4 - @entity3 fusions predominate in @entity7 (supporting previous reports that @entity5 rearrangement is rare in @entity7 ) and that RT-PCR has a comparable detection rate to FISH for @entity7 . Importantly, cases of @entity7 can be missed if RT-PCR is not performed in conjunction with FISH, and RT-PCR has the added advantage of specificity, which is crucial, as @entity4 rearrangements are present in a variety of @entity1 in the histologic differential diagnosis of @entity7 , that differ in behavior and treatment.

title: XXXX : comparison of fluorescence in situ hybridization and reverse transcription polymerase chain reaction as adjunct diagnostic modalities.

answer: @entity7


abstract: UNASSIGNED: Suppressive myeloid cells represent a significant barrier to the generation of productive antitumor immune responses to many solid @entity0 . Eliminating or reprogramming suppressive myeloid cells to abrogate @entity0 -associated immune suppression is a promising therapeutic approach. We asked whether treatment of @entity2 disseminated @entity3 with the immunotherapeutic attenuated @entity4 vaccine strain CPS would trigger @entity0 -associated myeloid cells to generate therapeutic antitumor immune responses. CPS treatment significantly decreased @entity0 -associated macrophages and markedly increased @entity3 microenvironment. Tumor-resident macrophages and dendritic cells, particularly cells actively invaded by CPS, increased expression of costimulatory molecules CD80 and CD86 and concomitantly boosted their production of IL12. CPS treatment increased CD4(+) and CD8(+) T-cell infiltration into the @entity0 microenvironment, activated @entity0 -resident T cells, and increased IFNy production by T-cell populations. CPS treatment provided a significant therapeutic benefit in @entity3 -bearing @entity1 . This therapeutic benefit depended on IL12 and IFNy production, MyD88 signaling, and CD8(+) T-cell populations. Although CD4(+) T cells exhibited activated effector phenotypes and produced IFNy, CD4(+) T cells as well as natural killer cells were not required for the therapeutic benefit. In addition, CD8(+) T cells isolated from CPS-treated @entity0 -bearing @entity1 produced IFNy after re-exposure to @entity3 antigen, suggesting this immunotherapeutic treatment stimulated @entity0 cell antigen-specific CD8(+) T-cell responses. This work highlights the potency and immunotherapeutic efficacy of CPS treatment and demonstrates the significance of targeting @entity0 -associated myeloid cells as a mechanism to stimulate more effective immunity to @entity3 . Cancer Immunol Res; 3(8); 1-11.   2015 AACR.

title: Attenuated @entity4 Stimulates Immunity to XXXX by Manipulation of Myeloid Cell Populations.

answer: @entity3


abstract: UNASSIGNED: Suppressive myeloid cells represent a significant barrier to the generation of productive antitumor immune responses to many solid @entity0 . Eliminating or reprogramming suppressive myeloid cells to abrogate @entity0 -associated immune suppression is a promising therapeutic approach. We asked whether treatment of @entity2 disseminated @entity3 with the immunotherapeutic attenuated @entity4 vaccine strain CPS would trigger @entity0 -associated myeloid cells to generate therapeutic antitumor immune responses. CPS treatment significantly decreased @entity0 -associated macrophages and markedly increased @entity3 microenvironment. Tumor-resident macrophages and dendritic cells, particularly cells actively invaded by CPS, increased expression of costimulatory molecules CD80 and CD86 and concomitantly boosted their production of IL12. CPS treatment increased CD4(+) and CD8(+) T-cell infiltration into the @entity0 microenvironment, activated @entity0 -resident T cells, and increased IFNy production by T-cell populations. CPS treatment provided a significant therapeutic benefit in @entity3 -bearing @entity1 . This therapeutic benefit depended on IL12 and IFNy production, MyD88 signaling, and CD8(+) T-cell populations. Although CD4(+) T cells exhibited activated effector phenotypes and produced IFNy, CD4(+) T cells as well as natural killer cells were not required for the therapeutic benefit. In addition, CD8(+) T cells isolated from CPS-treated @entity0 -bearing @entity1 produced IFNy after re-exposure to @entity3 antigen, suggesting this immunotherapeutic treatment stimulated @entity0 cell antigen-specific CD8(+) T-cell responses. This work highlights the potency and immunotherapeutic efficacy of CPS treatment and demonstrates the significance of targeting @entity0 -associated myeloid cells as a mechanism to stimulate more effective immunity to @entity3 . Cancer Immunol Res; 3(8); 1-11.   2015 AACR.

title: Attenuated XXXX Stimulates Immunity to @entity3 by Manipulation of Myeloid Cell Populations.

answer: @entity4


abstract: UNASSIGNED: Evaluation of stem cell-derived cardiomyocytes (SC-CM) using @entity7 ( @entity7 ) has attracted attention as a novel model to detect drug-induced @entity1 . An experiment was conducted to determine if @entity7 recording from @entity0 induced pluripotent SC-CM (hiPSC-CM) could assess proarrhythmic risk. Ten @entity6 blockers, 4 @entity4 blockers, and 1 IKs blocker were evaluated blindly. Eight drugs are associated with @entity2 ( @entity2 ) and four are not. Multiple parameters, including field potential duration (FPD), @entity4 slope, @entity4 amplitude, beat rate (BR), and early after-depolarization (EAD) were recorded. @entity5 ( @entity5 ) that elicited a significant change were calculated. Our results determined that FPD and EAD were unable to distinguish torsadogenic from benign compounds, @entity4 slope and amplitude could not differentiate @entity4 channel blockade from @entity6 blockade, BR had an inconsistent response to pharmacological treatment, and that hiPSC-CM were, in general, insensitive to IKs inhibition. A ratio was calculated that relates @entity5 for evoking FPD prolongation, or triggering EAD, to the @entity0 therapeutic unbound Cmax ( @entity5 /Cmax). The key finding was that the ratio was sensitive, but specificity was low. Consistently, the ratio had high positive predictive value and low negative predictive value. In conclusion, @entity7 recordings of hiPSC-CM were sensitive for FPD and EAD detection, but unable to distinguish agents with low- and high-risk for TdPs. While some published reports suggested great potential for @entity7 recordings in hSC-CM to assess preclinical @entity3 , the current evaluation implies that this model would have a high false positive rate in regard to proarrhythmic risk.

title: Proarrhythmia Risk Assessment in @entity0 Induced Pluripotent Stem Cell-Derived Cardiomyocytes using the Maestro XXXX Platform.

answer: @entity7


abstract: UNASSIGNED: Evaluation of stem cell-derived cardiomyocytes (SC-CM) using @entity7 ( @entity7 ) has attracted attention as a novel model to detect drug-induced @entity1 . An experiment was conducted to determine if @entity7 recording from @entity0 induced pluripotent SC-CM (hiPSC-CM) could assess proarrhythmic risk. Ten @entity6 blockers, 4 @entity4 blockers, and 1 IKs blocker were evaluated blindly. Eight drugs are associated with @entity2 ( @entity2 ) and four are not. Multiple parameters, including field potential duration (FPD), @entity4 slope, @entity4 amplitude, beat rate (BR), and early after-depolarization (EAD) were recorded. @entity5 ( @entity5 ) that elicited a significant change were calculated. Our results determined that FPD and EAD were unable to distinguish torsadogenic from benign compounds, @entity4 slope and amplitude could not differentiate @entity4 channel blockade from @entity6 blockade, BR had an inconsistent response to pharmacological treatment, and that hiPSC-CM were, in general, insensitive to IKs inhibition. A ratio was calculated that relates @entity5 for evoking FPD prolongation, or triggering EAD, to the @entity0 therapeutic unbound Cmax ( @entity5 /Cmax). The key finding was that the ratio was sensitive, but specificity was low. Consistently, the ratio had high positive predictive value and low negative predictive value. In conclusion, @entity7 recordings of hiPSC-CM were sensitive for FPD and EAD detection, but unable to distinguish agents with low- and high-risk for TdPs. While some published reports suggested great potential for @entity7 recordings in hSC-CM to assess preclinical @entity3 , the current evaluation implies that this model would have a high false positive rate in regard to proarrhythmic risk.

title: Proarrhythmia Risk Assessment in XXXX Induced Pluripotent Stem Cell-Derived Cardiomyocytes using the Maestro @entity7 Platform.

answer: @entity0


abstract: PURPOSE: The purpose of this study was to examine the effect of @entity1 self-management education (DSME) provided in a large urban @entity2 ( @entity2 ) by a certified @entity1 educator using a "learner-centered" approach to teaching survival skills. It was hypothesized that an intervention providing learner-centered education in the @entity2 would significantly improve @entity1 knowledge and self-management skills. METHODS: @entity0 were @entity0 who presented to the @entity2 with uncontrolled blood @entity3 with @entity1 ( @entity1 ). A learner-centered DSME approach was developed. Baseline knowledge and skills were assessed in the @entity2 with a 5-question test and a request to demonstrate meter and insulin injection technique. Education focused on identified gaps in knowledge and skills and incorporated an opportunity for the @entity0 to exercise control in the treatment process. At outpatient follow-up, knowledge retention was assessed with the same 5-question test, and skills again were tested. RESULTS: @entity0 with @entity1 who were provided learner-centered DSME in the @entity2 demonstrated a significant increase in knowledge-related test scores on all questions at follow-up. Significantly fewer @entity0 required meter and insulin injection instruction postintervention, compared to the baseline. CONCLUSION: Study results provide evidence supporting the effectiveness of learner-centered DSME delivered in the @entity2 at imparting critical knowledge and skills to @entity0 with @entity1 .

title: Successful @entity0 XXXX Education in the Emergency Department.

answer: @entity1


abstract: PURPOSE: The purpose of this study was to examine the effect of @entity1 self-management education (DSME) provided in a large urban @entity2 ( @entity2 ) by a certified @entity1 educator using a "learner-centered" approach to teaching survival skills. It was hypothesized that an intervention providing learner-centered education in the @entity2 would significantly improve @entity1 knowledge and self-management skills. METHODS: @entity0 were @entity0 who presented to the @entity2 with uncontrolled blood @entity3 with @entity1 ( @entity1 ). A learner-centered DSME approach was developed. Baseline knowledge and skills were assessed in the @entity2 with a 5-question test and a request to demonstrate meter and insulin injection technique. Education focused on identified gaps in knowledge and skills and incorporated an opportunity for the @entity0 to exercise control in the treatment process. At outpatient follow-up, knowledge retention was assessed with the same 5-question test, and skills again were tested. RESULTS: @entity0 with @entity1 who were provided learner-centered DSME in the @entity2 demonstrated a significant increase in knowledge-related test scores on all questions at follow-up. Significantly fewer @entity0 required meter and insulin injection instruction postintervention, compared to the baseline. CONCLUSION: Study results provide evidence supporting the effectiveness of learner-centered DSME delivered in the @entity2 at imparting critical knowledge and skills to @entity0 with @entity1 .

title: Successful XXXX @entity1 Education in the Emergency Department.

answer: @entity0


abstract: This population based cross-sectional study was conducted on 8283 @entity0 of all ages in five districts, selected conveniently, to assess the magnitude of @entity6 , their causes and consequences in rural Bangladesh. Six Upazilas from five districts and from each Upazila one Union was selected randomly. One village, the ultimate cluster, was then selected conveniently from each Union. All @entity0 (n = 8283) in the 8 villages were then surveyed. Out of 8283 population (ranging from 1-120 years) surveyed, 167(2%) had history and/or evidence of past @entity5 with a yearly incidence of 6.2 per 1000 per year. Study demonstrated a female predominance with male to female ratio being roughly 4:5. Majority (82%) had at least one episode of @entity1 in their life-time with mean age at 1st @entity1 being 20 years. Nearly 40% of the @entity1 were caused by blunt objects followed by penetrating object (22.3%) and sharp instrument (18.1%) with home being the primary place of occurrence (55.1%). Evidence of @entity5 was found on eye-lid (15%), conjunctiva (11.4%) and @entity3 (10.2%) as scars. The older @entity0 (>=  30 years), females, illiterates, agriculture labors, housewives and household workers were more likely to receive @entity1 . Majority (86.8%) of the subjects received treatment following injury. The median time lapsed between injuries and receiving first treatment was 5 days and that between injury and visiting an eye-specialist was 18 days. Self-treatment and treatment from over-the-counter comprised 45% and 42.1% respectively followed by eye-specialists (25.5%), village quack (22.8%), graduate doctors (19.3%) and traditional healers (6.9%). About 87% received conservative management, with 12.4% needing hospitalization. Most of the injured (92.8%) and non-injured (95.2%) eyes had normal vision before @entity1 as informed by the respondents. Following @entity1 , 18% had impaired, 10.7% severely @entity2 and about 6% were blind. Job abstinence due to @entity1 was 53% with median wage loss being 10 days. The study concludes that point-prevalence of @entity5 in rural area is around 2% with blunt objects commonly causing the @entity1 and one in every 16 @entity1 -hit case undergo blind. @entity4 from @entity5 , should, therefore, be a priority for eye care programs in rural Bangladesh.

title: XXXX : Prevalence in different rural population of Bangladesh.

answer: @entity6


abstract: This survey was conducted on 1000 physicians with @entity2 management responsibilities practicing in 47 districts in Bangladesh. The response rate was 58.3%. The physicians had a mean of 21 years in practice. It was notable that 66% of the physicians had seen @entity1 @entity0 in the last 12 months and 63% had seen @entity0 with advanced stage @entity1 where @entity3 are considered as the mainstay of treatment. It was discouraging that 85% of the physicians preferred to prescribe @entity4 , when @entity0 needed @entity3 for severe @entity2 . 53% of the physicians were not aware of the 'Bangladesh Narcotics law, 1990'. 89% of the physicians would restrict opioid dosage in @entity2 management to prevent drug tolerance or addiction. Oncology physicians displayed significantly higher knowledge scores. The results demonstrated physicians' poor knowledge, attitude and perceived barriers regarding @entity3 . Effective education strategies need to be addressed using the study result.

title: Physicians knowledge and attitude of opioid availability, accessibility and use in XXXX management in Bangladesh.

answer: @entity2


abstract: OBJECTIVE: @entity0 with @entity6 have an increased risk of developing colorectal and gynecologic @entity1 such as @entity3 . @entity4 has about a 30% risk of developing into @entity3 . The aim of this study was to determine the genetic risk for developing @entity3 by immunohistochemical staining of @entity2 for @entity7 , mutS homolog 2, mutS homolog 6, and postmeiotic segregation increased 2. METHODS: Twenty cases (n=20) were selected from among @entity0 with available sample blocks for analysis. Clinical information was obtained from medical chart review. Immunohistochemical staining was performed for all of the @entity1 blocks. Staining was scored based on the intensity (intensity score 0-3) . RESULTS: Among the 20 cases of @entity5 , 11 (55%) @entity0 showed loss of expression of at least one of the following proteins: @entity7 , mutS homolog 2, mutS homolog 6, or postmeiotic segregation increased 2. Seven (35%) @entity0 were negative for the expression of two or more proteins, and one @entity0 (5%) was negative for the expression of all four proteins. CONCLUSION: More than half of the @entity0 showed loss of expression of at least one mismatch repair protein in our study population. Genetic risk counseling and further tests are recommended for these @entity0 .

title: Clinical significance of mismatch repair genes immunohistochemical expression of XXXX .

answer: @entity5


abstract: OBJECTIVE: To analyze the prognostic role of revised version of International Federation of Gynecology and Obstetrics (FIGO) stage (2013) in @entity1 and compare with previous version staging classification. METHODS: We retrospectively enrolled @entity0 with @entity1 treated at Samsung Medical Center from 2002 to 2012. We reclassified the @entity0 based on the revised FIGO staging classification. RESULTS: Eight hundred seventy-eight @entity0 were enrolled (stage I, 22.8%; stage II, 10.4%; stage III, 56.2%; stage IV, 10.7%). Previous stage IC (98, 11.1%) was subdivided into @entity4 (9, 1.0%), @entity3 (57, 6.4%), and IC3 (32, 4.1%). In addition, previous stage IV (94, 1.7%) was categorized into @entity2 (37, 4.2%) and IVB (57, 6.5%) in new staging classification. Stage IIC (66, 7.5%) has been eliminated and integrated into IIA (36, 4.1%) and IIB (55, 6.2%) in revised classification. Revised FIGO stage IC3 had significant prognostic impact on PFS (hazard ratio [HR], 3.840; 95% confidence interval [CI], 1.361 to 10.83; P=0.011) and revised FIGO stage IIIC appears to be an independent, significant poor prognostic factor for PFS (HR, 2.541; 95% CI, 1.242 to 5.200; P=0.011) but not in the case of previous version of FIGO stage IIIC (HR, 1.070; 95% CI, 0.502 to 2.281; P=0.860). However, any sub-stages of both previous and revised version in stage II and IV, there was no significant prognostic role. CONCLUSION: Revised FIGO stage has more progressed utility for informing prognosis than previous version, especially in stage I and III. For stage II and IV, further validation should be needed in large population based study in the future.

title: Survival analysis of revised 2013 FIGO staging classification of XXXX and comparison with previous FIGO staging classification.

answer: @entity1


abstract: PURPOSE: Previous studies have demonstrated vertebral coplanar alignment (VCA) as an effective surgical option for @entity5 ( @entity5 ). The purpose of this study is to analyze the outcome of VCA for the surgical correction of adult @entity6 (AdIS). METHODS: 35 AdIS @entity0 (mean age: 24.2  years) undergoing VCA-instrumentation were reviewed. The main thoracic curve and @entity4 ( @entity4 , T5-T12) were evaluated preoperatively, immediate postoperatively, and at the final follow-up (>1  year). All @entity0 were stratified by the @entity4 modifier before surgery: "+" ( @entity4 , >40  ), "-" ( @entity4 , <10  ), and "N" ( @entity4 , 10  -40  ) for normal. The apical vertebral body-to-rib ratio (AVB-R), rib hump (RH), and rotational angle to sacrum (RAsac) were measured to assess the correction of @entity2 . Quality of life was evaluated with @entity7 -20 questionnaires. RESULTS: The main thoracic curve (59.1   vs. 19.3  , P  <  0.001) and @entity2 (AVB-R: 2.4 vs. 1.7  %, P  <  0.001, RH: 34.9 vs. 19.1  mm, P  <  0.001, RAsac: 19.6   vs. 11.9  , P  <  0.001) were significantly reduced with surgery. @entity1 improved significantly in group "+" (51.4   vs. 31.6  , P  <  0.001) and group "-" (6.2   vs. 20.1  , P  <  0.001), while no significant postoperative change in @entity4 was observed in group "N" (23.5   vs. 26.3  , P  =  0.270). @entity0 were followed for an average of 18.7  months with no significant loss of correction. @entity7 scores improved greatly from 57.7 preoperatively to 71.6 at the final follow-up. CONCLUSIONS: VCA can be effectively used for the correction of the @entity2 , with better sagittal profile restoration in adult thoracic @entity6 with @entity3 .

title: Vertebral coplanar alignment technique: a surgical option for correction of adult thoracic XXXX .

answer: @entity6


abstract: BACKGROUND: Sexuality is an important aspect of the personality of an individual and influences psychological, physical and social well-being of both @entity0 and @entity0 . It is a paradox, that in the country where 'kamasutra' (by Vatsyayana) took birth, there is a lack of research publications and sexuality related literature; hence the current study was conducted, to estimate the prevalence and association of @entity1 with various socio-demographic variables, in the selected rural population. MATERIALS AND METHODS: Subjects who were sexually active and fulfilled the study criteria were administered Arizona Sexual Experience Scale as screening tool for the presence of sexual problems. Those who were found to be having sexual problems were interviewed further using appropriate questionnaires. RESULTS: 21.15% of the male subjects were diagnosed to have one (or more) @entity1 . Prevalence of @entity2 was found to be 15.77%, male @entity3 ( @entity3 ) 2.56%; @entity5 was found to be prevalent in 8.76% of the male subjects. Around 14% of the female subjects were diagnosed to have female @entity1 . Prevalence of female arousal dysfunction was found to be 6.65%, female @entity3 8.87%, female anorgasmia 5.67%, female @entity4 2.34% and female @entity3 was found to be prevalent in 0.37% of the female subjects. CONCLUSION: This study concluded that one in five males and one in seven females were suffering from one (or more) @entity1 . Improving the training of undergraduate medical and nursing students in sexuality related issues, increasing trained individuals in sexual medicine by starting new courses, providing sex education to the general population using media and merging sexual health care with primary care, are likely to play a significant role in addressing the increasing sexual health morbidity.

title: An epidemiological study of XXXX in south Indian rural population.

answer: @entity1


abstract: PURPOSE: We introduce a new method combined with the deformable image registration (DIR) and regions-of-interest mapping (ROIM) technique to accurately calculate dose on daily CBCT for @entity4 . METHODS: @entity0 suffered from @entity4 were enrolled in the study. Prescription was set to 66 Gy/30 F and 54 Gy/30 F to the @entity1 (PTV66) and subclinical disease (PTV54) . Planning CT (pCT) were segmented into 8 substructures in terms of their differences in physical density, such as gross target volume (GTV), venae cava superior ( @entity5 ), aorta, heart, spinal cord, lung, muscle and bones. The pCT and its substructures were transferred to the MIM software to readout their mean HU values. Afterwards, a deformable planning CT to daily KV-CBCT image registration method was then utilized to acquire a new structure set on CBCT. The newly generated structures on CBCT were then transferred back to the treatment planning system (TPS) and its HU information were overridden manually with mean HU values obtained from pCT. Finally, the treatment plan was projected onto the CBCT images with the same beam arrangements and monitor units (MUs) to accomplish dose calculation. Planning target volume ( @entity2 ) and @entity3 ( @entity3 ) from both of the pCT and CBCT were compared to evaluate the dose calculation accuracy. RESULTS: It was found that the dose distribution in the CBCT showed little differences compared to the pCT, regardless of whether @entity2 or @entity3 were concerned. Specifically, dose variation in GTV, PTV54, PTV66, @entity5 , lung and heart were within 0.1%. The maximum dose variation was presented in the spinal cord, which was up to 2.7% dose difference. CONCLUSION: The proposed method combined with DIR and ROIM technique to accurately calculate dose distribution on CBCT for @entity4 is feasible.

title: SU-E-J-100: The Combination of Deformable Image Registration and Regions-Of-Interest Mapping Technique to Accomplish Accurate Dose Calculation On Cone Beam Computed Tomography for XXXX .

answer: @entity4


abstract: PURPOSE: To quantify @entity0 motion during hypo-fractionated @entity1 treatment as tracked by Calypso    4D localization system. METHODS: 50 @entity1 @entity0 with implanted Calypso beacons underwent hypofractionated IMRT treatment. Typical fraction size was 5 with doses of 5-8 Gy/fraction. 213 traces from the 50 @entity0 were analyzed to quantify the probability of motion vs time starting from beam-on. Couch corrections applied by therapists were undone to obtain the natural course of @entity0 motion. The Calypso data was used to identify vector displacements greater than 2 mm from the starting position. The direction of this vector was classified into one of the 26 directions (combinations of L/R, A/P, S/I). The probability of motion >2mm was estimated by computing the fraction of traces that exceed the 2mm threshold at each time point. The violating motion points were also binned by direction in order to identify specific directions that were more prone to movement. RESULTS: The overall probability of motion greater than 2 mm at 5 and 10 minutes from beam-on were 27 % and 50% respectively. The primary directions in which motion occurred were Posterior-Inferior (PI) and Inferior (I) with a probability of 8.5% and 4% at 5 minutes and 10% for both at 10 minutes. Motion was classified into the following bins: 0-2, 2-3, 3-4, 4-5, 5-6, 6-7, 7-8 and greater than 8 mm. It is observed that motion < 2mm decreases from the first 5 minutes to the next while the higher magnitude components increase with time. CONCLUSION: The probability of prostate motion increases with time. The trend seen in the PI and I directions can be attributed to physiological factors like @entity2 . This probability can be factored in for scheduling intrafraction imaging and used to compare dosimetric impact of VMAT vs. IMRT plans. This work is supported in part by Varian Medical Systems.

title: SU-E-J-183: Quantification of Motion During Hypo-Fractionated XXXX Radiation Therapy.

answer: @entity1


abstract: UNASSIGNED: Introduction   We evaluated outcome and resource utilization disparities between commercially insured, Medicaid, and Medicare @entity0 . We further analyzed racial disparities in a subset cohort. Methods   We reviewed the MarketScan database (2000-2009) for adult @entity2 ( @entity2 ) @entity0 . Analyses were performed to evaluate outcome differences by insurance type and race. Outpatient service utilization disparities by insurance and race were also evaluated. Results   Our study included 92,159 @entity2 @entity0 , 44,108 (47.9%) of whom utilized commercial insurance, 19,743 (21.4%) utilized Medicaid, and 28,308 (30.7%) utilized Medicare. In-hospital mortality was lowest for commercially insured (5.0%) versus 7.6% and 8.5% for Medicaid and Medicare @entity0 , respectively (p   <   0.0001). Medicaid @entity0 had a longer hospitalization than commercially insured (12 days versus 6 days; p   <   0.0001). Medicaid @entity0 were 1.29 and 1.78 times more likely to die and experience complications than the commercially insured. Females had a lower mortality risk (odds ratio [OR]: 0.80, p   <   0.0001) and less complications (OR: 0.67; p   <   0.0001) than males. Higher comorbidities increased mortality risk (OR: 2.71; p   <   0.0001) and complications (OR: 2.96, p   <   0.0001). @entity1 @entity0 had lower mortality (OR: 0.01; p   <   0.0001) and less complications (OR: 0.07; p   <   0.0001). Medicare (OR: 1.33; p   <   0.0001) and higher comorbidity (OR: 1.26; p   <   0.0001) @entity0 utilized outpatient rehabilitation services more frequently. Medicare @entity0 had twice the emergency department visits as the commercially insured (p   <   0.0001). Medicare (16.6%) @entity0 utilized more rehabilitation than commercially insured (13.4%) and Medicaid (9.1%) @entity0 . Racial disparities were analyzed in a subset of 12,847 white and 4,780 African American (AA) @entity0 . Multivariate analysis showed that AAs were more likely to experience a complication than white @entity0 (OR: 1.13; p   =   0.0024) and less likely to utilize outpatient rehabilitation services (OR: 0.83; p   =   0.0025) than whites. Conclusions   Insurance and racial disparities continue to exist for @entity2 @entity0 . Insurance status appears to have an impact on short- and long-term outcomes to a greater degree than @entity0 race.

title: Effect of Insurance and Racial Disparities on Outcomes in XXXX .

answer: @entity2


abstract: INTRODUCTION AND OBJECTIVES: Cetuximab and panitumumab are monoclonal antibodies that target the @entity3 ( @entity3 ) in the treatment of metastatic @entity2 . Most @entity0 develop a @entity4 , which may predict @entity1 response. We studied whether the other adverse cutaneous effects associated with these monoclonal antibodies are also clinical predictors of response. We also reviewed publications describing approaches to treating the @entity4 since no evidence-based guidelines have yet been published. MATERIAL AND METHODS: We performed a retrospective study of 116 @entity0 with metastatic @entity2 receiving anti-EGRF therapy with cetuximab or panitumumab at Hospital Universitario Donostia. RESULTS: In total, 81.9% of the @entity0 developed a @entity4 . @entity0 who received the most cycles of treatment with the @entity3 inhibitor were at the highest risk of developing the @entity4 , and these @entity0 also had the most severe @entity4 reactions (P=.03). All of the @entity0 who exhibited a complete @entity1 response had the @entity4 , and the incidence of @entity4 was lower in @entity0 with poor @entity1 response (P=.03). We also observed an association between @entity1 response and xerosis (53.4% of the @entity0 who developed xerosis also exhibited @entity1 response, P=.002). The @entity4 was managed according to an algorithm developed by our department. CONCLUSIONS: Severe @entity4 and xerosis may be clinical predictors of good response to anti- @entity3 therapy. @entity0 who develop a @entity4 should be treated promptly because suboptimal treatment of this and other adverse effects can lead to delays in taking the prescribed anti- @entity3 dose or to interruption of therapy.

title: Predictors of XXXX Response to Cetuximab and Panitumumab in 116 @entity0 and a Review of Approaches to Managing Skin Toxicity.

answer: @entity1


abstract: INTRODUCTION AND OBJECTIVES: Cetuximab and panitumumab are monoclonal antibodies that target the @entity3 ( @entity3 ) in the treatment of metastatic @entity2 . Most @entity0 develop a @entity4 , which may predict @entity1 response. We studied whether the other adverse cutaneous effects associated with these monoclonal antibodies are also clinical predictors of response. We also reviewed publications describing approaches to treating the @entity4 since no evidence-based guidelines have yet been published. MATERIAL AND METHODS: We performed a retrospective study of 116 @entity0 with metastatic @entity2 receiving anti-EGRF therapy with cetuximab or panitumumab at Hospital Universitario Donostia. RESULTS: In total, 81.9% of the @entity0 developed a @entity4 . @entity0 who received the most cycles of treatment with the @entity3 inhibitor were at the highest risk of developing the @entity4 , and these @entity0 also had the most severe @entity4 reactions (P=.03). All of the @entity0 who exhibited a complete @entity1 response had the @entity4 , and the incidence of @entity4 was lower in @entity0 with poor @entity1 response (P=.03). We also observed an association between @entity1 response and xerosis (53.4% of the @entity0 who developed xerosis also exhibited @entity1 response, P=.002). The @entity4 was managed according to an algorithm developed by our department. CONCLUSIONS: Severe @entity4 and xerosis may be clinical predictors of good response to anti- @entity3 therapy. @entity0 who develop a @entity4 should be treated promptly because suboptimal treatment of this and other adverse effects can lead to delays in taking the prescribed anti- @entity3 dose or to interruption of therapy.

title: Predictors of @entity1 Response to Cetuximab and Panitumumab in 116 XXXX and a Review of Approaches to Managing Skin Toxicity.

answer: @entity0


abstract: OPINION STATEMENT: @entity2 ( @entity2 ) is the fourth most common @entity1 in Europe and is the leading cause of @entity3 among @entity0 with @entity1 . This is due to the fact that the majority of the @entity0 are diagnosed with advanced stage disease. In these stages, extensive intraperitoneal metastases are often present, making therapy more difficult. The current standard treatment involves primary or interval cytoreductive surgery and chemotherapy. However, many @entity0 develop intraperitoneal (IP) recurrences despite complete surgery and chemotherapy. Therefore, alternative ways to deliver chemotherapy have been examined. Administration of the chemotherapy directly into the peritoneal @entity5 allows high doses of the cytotoxic agent at the site of the @entity1 , while minimizing the occurrence of systemic side effects. Theoretically, IP administration is most beneficial when only microscopic disease is present since penetration of the drug is limited to a few millimeters. IP chemotherapy can be administered during surgery under hyperthermic conditions (HIPEC) or during regular chemotherapy courses through a catheter placed into the abdominal @entity5 . IP administration results in an improved survival, although catheter-related morbidity is reported. @entity4 potentiates the cytotoxic effect of chemotherapy and may therefore have an additional positive effect on prognosis. Although recent observational studies show encouraging results with respect to effect on survival and rate of complications, it remains a challenge to identify those @entity0 who would benefit most from adding HIPEC to the standard treatment. In this respect, age and timing of HIPEC during treatment might be important factors, although no convincing evidence is available yet. Currently, a total of 18 clinical trials are open and to answer the above-mentioned questions, it is adamant to complete these trials, especially the randomized phase III trials. Accrual is hampered by the fact that HIPEC is currently offered as standard treatment in some centers even though convincing evidence is not yet available. If these phase III trials show positive results in favor of HIPEC, subsequent trials comparing surgery and postoperative IP chemotherapy with surgery and HIPEC seem a logical next step.

title: The role of hyperthermic intraperitoneal intraoperative chemotherapy in XXXX .

answer: @entity2


abstract: OBJECTIVE: To detect the activity of autophagy and explore the impact on survival and proliferation of HEL cells and hematopoietic cells of @entity4    @entity0 with @entity2 @entity3 mutation. METHODS: Flow cytometry, AO staining and Western blot methods were used to detect the autophagy activity and the expression of @entity6 -    protein of @entity2 @entity3 + HEL cells and hematopoietic cells of 12 newly diagnosed @entity4 @entity0 with @entity2 @entity3 mutation. HEL cells and bone marrow cells of 3 @entity4 @entity0 were treated with @entity1 or @entity5 to induce and inhibit autophagy, respectively. CellTiter Glo(R) method was used to detect the proliferation activity of cells. RESULTS: There was higher level of mean @entity6 -    fluorescence intensity in HEL cells (159 389  29 001) than that in K562 cells (96 047  24 134) (P=0.044). The formation of autophagosome in HEL cells is more than that in K562 cells detected by microscope. What's more, the level of mean @entity6 -    fluorescence intensity in 12 @entity4 @entity0 ' myeloid cells (92 842  4 250) was higher than that of 15 healthy volunteers (86 633  2 504) (P=0.001). The expression of @entity6 -    protein was higher in @entity4 @entity0 ' peripheral blood cells than that in healthy volunteers detected by Western blot. After treated with @entity1 12, 24, 48 h, the activity of autophagy in HEL cells and bone marrow cells of 3 @entity4 @entity0 were increased and the proliferation activity was higher than the control group, the proliferation activity at 48 h were (101 413  3 720), (18 744  1 015), respectively. However, after treated with @entity5 12, 24, 48 h, the activity of autophagy was decreased and the proliferation activity was lower than the control group, the proliferation activity at 48 h were (5 732  166), (5 371  56), respectively. CONCLUSION: There is high basical activity of autophagy in @entity2 @entity3 + HEL cells and hematopoietic cells of @entity4 @entity0 with @entity2 @entity3 mutation. Up-regulated autophagy promotes proliferation of @entity2 @entity3    HEL cells and bone marrow cells of @entity4 @entity0 with @entity2 @entity3 mutation. Decreased autophagy inhibits proliferation of @entity2 @entity3 + HEL cells and bone marrow cells of @entity4 @entity0 with @entity2 @entity3 mutation.

title: [The impact of autophagy on proliferation of HEL cells and hematopoietic cells of polycythemia vera @entity0 with XXXX @entity3 mutation].

answer: @entity2


abstract: OBJECTIVE: To detect the activity of autophagy and explore the impact on survival and proliferation of HEL cells and hematopoietic cells of @entity4    @entity0 with @entity2 @entity3 mutation. METHODS: Flow cytometry, AO staining and Western blot methods were used to detect the autophagy activity and the expression of @entity6 -    protein of @entity2 @entity3 + HEL cells and hematopoietic cells of 12 newly diagnosed @entity4 @entity0 with @entity2 @entity3 mutation. HEL cells and bone marrow cells of 3 @entity4 @entity0 were treated with @entity1 or @entity5 to induce and inhibit autophagy, respectively. CellTiter Glo(R) method was used to detect the proliferation activity of cells. RESULTS: There was higher level of mean @entity6 -    fluorescence intensity in HEL cells (159 389  29 001) than that in K562 cells (96 047  24 134) (P=0.044). The formation of autophagosome in HEL cells is more than that in K562 cells detected by microscope. What's more, the level of mean @entity6 -    fluorescence intensity in 12 @entity4 @entity0 ' myeloid cells (92 842  4 250) was higher than that of 15 healthy volunteers (86 633  2 504) (P=0.001). The expression of @entity6 -    protein was higher in @entity4 @entity0 ' peripheral blood cells than that in healthy volunteers detected by Western blot. After treated with @entity1 12, 24, 48 h, the activity of autophagy in HEL cells and bone marrow cells of 3 @entity4 @entity0 were increased and the proliferation activity was higher than the control group, the proliferation activity at 48 h were (101 413  3 720), (18 744  1 015), respectively. However, after treated with @entity5 12, 24, 48 h, the activity of autophagy was decreased and the proliferation activity was lower than the control group, the proliferation activity at 48 h were (5 732  166), (5 371  56), respectively. CONCLUSION: There is high basical activity of autophagy in @entity2 @entity3 + HEL cells and hematopoietic cells of @entity4 @entity0 with @entity2 @entity3 mutation. Up-regulated autophagy promotes proliferation of @entity2 @entity3    HEL cells and bone marrow cells of @entity4 @entity0 with @entity2 @entity3 mutation. Decreased autophagy inhibits proliferation of @entity2 @entity3 + HEL cells and bone marrow cells of @entity4 @entity0 with @entity2 @entity3 mutation.

title: [The impact of autophagy on proliferation of HEL cells and hematopoietic cells of polycythemia vera @entity0 with @entity2 XXXX mutation].

answer: @entity3


abstract: OBJECTIVE: To detect the activity of autophagy and explore the impact on survival and proliferation of HEL cells and hematopoietic cells of @entity4    @entity0 with @entity2 @entity3 mutation. METHODS: Flow cytometry, AO staining and Western blot methods were used to detect the autophagy activity and the expression of @entity6 -    protein of @entity2 @entity3 + HEL cells and hematopoietic cells of 12 newly diagnosed @entity4 @entity0 with @entity2 @entity3 mutation. HEL cells and bone marrow cells of 3 @entity4 @entity0 were treated with @entity1 or @entity5 to induce and inhibit autophagy, respectively. CellTiter Glo(R) method was used to detect the proliferation activity of cells. RESULTS: There was higher level of mean @entity6 -    fluorescence intensity in HEL cells (159 389  29 001) than that in K562 cells (96 047  24 134) (P=0.044). The formation of autophagosome in HEL cells is more than that in K562 cells detected by microscope. What's more, the level of mean @entity6 -    fluorescence intensity in 12 @entity4 @entity0 ' myeloid cells (92 842  4 250) was higher than that of 15 healthy volunteers (86 633  2 504) (P=0.001). The expression of @entity6 -    protein was higher in @entity4 @entity0 ' peripheral blood cells than that in healthy volunteers detected by Western blot. After treated with @entity1 12, 24, 48 h, the activity of autophagy in HEL cells and bone marrow cells of 3 @entity4 @entity0 were increased and the proliferation activity was higher than the control group, the proliferation activity at 48 h were (101 413  3 720), (18 744  1 015), respectively. However, after treated with @entity5 12, 24, 48 h, the activity of autophagy was decreased and the proliferation activity was lower than the control group, the proliferation activity at 48 h were (5 732  166), (5 371  56), respectively. CONCLUSION: There is high basical activity of autophagy in @entity2 @entity3 + HEL cells and hematopoietic cells of @entity4 @entity0 with @entity2 @entity3 mutation. Up-regulated autophagy promotes proliferation of @entity2 @entity3    HEL cells and bone marrow cells of @entity4 @entity0 with @entity2 @entity3 mutation. Decreased autophagy inhibits proliferation of @entity2 @entity3 + HEL cells and bone marrow cells of @entity4 @entity0 with @entity2 @entity3 mutation.

title: [The impact of autophagy on proliferation of HEL cells and hematopoietic cells of polycythemia vera XXXX with @entity2 @entity3 mutation].

answer: @entity0


abstract: Regional cerebral blood flow (rCBF) was measured in 254 areas of a hemisphere with the intraarterial 133-xenon method in seven @entity0 before and during classical @entity3 attacks. During prodromes/accompaniments focal flow was markedly reduced (mean 36 p. cent. range 22-60 p. cents). Initial focal @entity2 was observed in three @entity0 , loss of functional focal activation in six @entity0 and @entity1 during oligemia in four @entity0 . The oligemia was observed in all seven @entity0 . It started at the posterior pole of the brain and gradually spread anteriorly in the course of 15-45 minutes. The findings indicate that a simple vasospastic model of the classical @entity3 attack is not likely. In six @entity0 with common @entity3 , attacks were induced with red wine. On eight occasions rCBF was measured before and after provocation, and just before and during induction of @entity3 attacks. In three @entity0 stationary detection and @entity4 was used. In one @entity0 intra-arterial xenon and in four @entity0 @entity4 and 133-xenon tomography measuring from about 700 regions of the brain. Measurements were taken about 15 minutes apart. In no @entity0 was oligemia observed at any time. The results suggest that the pathogenesis of common @entity3 is different from that of classical @entity3 .

title: Is ischemia involved in the pathogenesis of XXXX ?

answer: @entity3


abstract: PURPOSE: To evaluate changes in the @entity1 ( @entity1 ) and effective depth of treatment based on exerted force by applicator on the skin during treatments of @entity2 with Xoft Electronic Brachytherapy. METHODS: To simulate compressible tissue, 5mm tissue-equivalent bolus was used. An ion chamber (Soft X-ray Chamber, PTW) and electrometer (Max 4000, Standard Imaging) were used for output measurements. Measurements were done for all available Xoft surface applicators (10, 20, 35, and 50mm cones) with plastic endcap. Fig1 shows the experimental setup. The @entity1 was measured first with no or minimal pressure of the applicator on the bolus, followed by increasing uniform pressure on the applicator applied with custom cerrobend weights. The measurements were used to calculate the effective @entity1 and effective depth. RESULTS: Force applied with the applicator was plotted against the change in @entity1 relative to the @entity1 when no force is applied. For the 10mm cone, moderate force of 5N can change the @entity1 by more than 20%, (Fig2). The effect is also pronounced for the 20mm cone, while it is minimal for the 35 and 50mm cones. Even when only moderate force is applied, the effective prescription depth can be changed by a several millimeters, which is on the order of the typical prescription depth (Fig3). CONCLUSION: Based on the results of this simulation, excessive pressure applied on the @entity0 's skin by the applicator cone can drastically alter the @entity1 and effective treatment depth. The effect is most pronounced for the 10mm cone, and to a lesser extent, 20mm, which is significant as these cones tend to be used most frequently in the clinic. Applicator placement therefore may Result in significant consequences such as excessive dose to target, severe skin reaction, permanent discoloration, skin indentation, and poor overall cosmesis upon completion of treatment.

title: SU-E-T-387: Evaluation of Effective Treatment Depth in XXXX Treatments with Xoft Electronic Brachytherapy.

answer: @entity2


abstract: OBJECTIVE: We examined obstetric and fetal/neonatal outcomes in @entity0 with a history of recurrent @entity1 . METHODS: We reviewed the obstetric records of all 5,829 nulliparous pregnant @entity0 who delivered at #8805;14 weeks' gestation from 2008 through 2013 at our perinatal center. Of these @entity0 , 74 had a history of recurrent @entity1 (1.3%). The control population consisted of 4,176 nulliparous @entity0 without a history of @entity1 . Demographic information and characteristics of labor were extracted from @entity0 charts. RESULTS: The rate of maternal age #8805;40 years (p<0.01) and the rate of in vitro fertilization use (p<0.01) were higher in @entity0 with recurrent @entity1 than in @entity0 without @entity1 . Eleven @entity0 with recurrent @entity1 (14.9%) were treated with low-dose aspirin with and without subcutaneous heparin. In addition, the rate of cesarean delivery was higher in @entity0 with recurrent @entity1 than in @entity0 without @entity1 (p=0.02). However, fetal/neonatal outcomes did not differ significantly between the populations. CONCLUSION: The pregnancy of @entity0 with a history of recurrent @entity1 is not associated with adverse outcomes at our perinatal center.

title: Clinical characteristics of pregnancies with a history of recurrent XXXX at a Japanese perinatal center.

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) involves a rapidly acting sedative plus a neuromuscular blocking agent (NMBA) to facilitate endotracheal intubation. @entity3 and @entity4 are NMBAs commonly used in @entity1 with drastically different durations of action. OBJECTIVES: Evaluate whether @entity0 receiving @entity1 with a longer-acting NMBA had a greater delay in sedation or @entity2 than @entity0 that received a short-acting NMBA. METHODS: This was a retrospective review of @entity0 presenting to the emergency department requiring endotracheal intubation. Exclusions included age < 18 years, pregnancy, prior intubation, and contraindication to sedation and @entity2 . Primary endpoint was time to continuous sedation or @entity2 after @entity1 in @entity0 receiving @entity3 or @entity4 . Secondary endpoints included hospital length of stay (HLOS), intensive care unit length of stay (ICU LOS), and impact of an emergency medicine pharmacist (EPh). RESULTS: A total 106 @entity0 met inclusion criteria, 76 @entity0 receiving @entity3 and 30 receiving @entity4 . Mean time to sedation or @entity2 was longer in the @entity3 group when compared to the @entity4 group at 34    36 min vs. 16    21 min (p = 0.002). In the presence of an EPh, the mean time to sedation or @entity2 was 20    21 min, vs. 49    45 min (p < 0.001). Time spent on ventilator, HLOS, and ICU LOS were not significantly different between groups. CONCLUSIONS: @entity0 receiving @entity3 in @entity1 had a significantly longer time to sedation or @entity2 when compared to @entity0 receiving @entity4 . The presence of an EPh significantly decreased the time to administration of sedation or @entity2 after @entity1 .

title: Impact of XXXX and @entity4 on Sedation Initiation After Rapid Sequence Intubation.

answer: @entity3


abstract: BACKGROUND: @entity1 ( @entity1 ) involves a rapidly acting sedative plus a neuromuscular blocking agent (NMBA) to facilitate endotracheal intubation. @entity3 and @entity4 are NMBAs commonly used in @entity1 with drastically different durations of action. OBJECTIVES: Evaluate whether @entity0 receiving @entity1 with a longer-acting NMBA had a greater delay in sedation or @entity2 than @entity0 that received a short-acting NMBA. METHODS: This was a retrospective review of @entity0 presenting to the emergency department requiring endotracheal intubation. Exclusions included age < 18 years, pregnancy, prior intubation, and contraindication to sedation and @entity2 . Primary endpoint was time to continuous sedation or @entity2 after @entity1 in @entity0 receiving @entity3 or @entity4 . Secondary endpoints included hospital length of stay (HLOS), intensive care unit length of stay (ICU LOS), and impact of an emergency medicine pharmacist (EPh). RESULTS: A total 106 @entity0 met inclusion criteria, 76 @entity0 receiving @entity3 and 30 receiving @entity4 . Mean time to sedation or @entity2 was longer in the @entity3 group when compared to the @entity4 group at 34    36 min vs. 16    21 min (p = 0.002). In the presence of an EPh, the mean time to sedation or @entity2 was 20    21 min, vs. 49    45 min (p < 0.001). Time spent on ventilator, HLOS, and ICU LOS were not significantly different between groups. CONCLUSIONS: @entity0 receiving @entity3 in @entity1 had a significantly longer time to sedation or @entity2 when compared to @entity0 receiving @entity4 . The presence of an EPh significantly decreased the time to administration of sedation or @entity2 after @entity1 .

title: Impact of @entity3 and XXXX on Sedation Initiation After Rapid Sequence Intubation.

answer: @entity4


abstract: Stimulation protocols for medical devices should be rationally designed. For episodic @entity3 we outline model-based design strategies toward preventive and acute therapies using stereotactic cortical neuromodulation. To this end, we regard a localized @entity1 ( @entity1 ) wave segment as a central element in @entity2 pathophysiology. To describe nucleation and propagation features of the @entity1 wave segment, we define the new concepts of cortical hot spots and labyrinths, respectively. In particular, we firstly focus exclusively on curvature-induced dynamical properties by studying a generic reaction-diffusion model of @entity1 on the folded cortical surface. This surface is described with increasing level of details, including finally personalized simulations using @entity0 's magnetic resonance imaging (MRI) scanner readings. At this stage, the only relevant factor that can modulate nucleation and propagation paths is the Gaussian curvature, which has the advantage of being rather readily accessible by MRI. We conclude with discussing further anatomical factors, such as areal, laminar, and cellular heterogeneity, that in addition to and in relation to Gaussian curvature determine the generalized concept of cortical hot spots and labyrinths as target structures for neuromodulation. Our numerical simulations suggest that these target structures are like fingerprints, they are individual features of each @entity2 sufferer. The goal in the future will be to provide individualized neural tissue simulations. These simulations should predict the clinical data and therefore can also serve as a test bed for exploring stereotactic cortical neuromodulation.

title: Cortical hot spots and labyrinths: why cortical neuromodulation for episodic XXXX should be personalized.

answer: @entity3


abstract: BACKGROUND: Latinos experience disproportionately higher rates of uncontrolled @entity1 as compared to Blacks and Whites. While poor adherence is a major contributor to disparities in blood pressure control, data in Latino @entity0 are scant. More importantly, translation of interventions to improve medication adherence in community-based primary care practices, where the majority of Latino @entity0 receive their care is non-existent. METHODS: Using a randomized controlled design, this study evaluates the effectiveness of a culturally tailored, practice-based intervention compared to usual care on medication adherence, among 148 Latino @entity0 with uncontrolled @entity1 who are non-adherent to their antihypertensive medications. Bilingual medical assistants trained as Health Coaches deliver the intervention using an electronic medical record system-embedded adherence script. @entity0 randomized to the intervention group receive @entity0 -centered counseling with a Health Coach to develop individualized self-monitoring strategies to overcome barriers and improve adherence behaviors. Health Coach sessions are held biweekly for the first 3 months (6 sessions total) and then monthly for the remaining 3 months (3 sessions total). @entity0 randomized to the usual care group receive standard @entity1 treatment recommendations as determined by their primary care providers. The primary outcome is the rate of medication adherence at 6 months. The secondary outcome is @entity2 at 6 months. DISCUSSION: If successful, findings from this study will provide salient information on the translation of culturallytailored, evidence-based interventions targeted at medication adherence and blood pressure control into practice-based settings for this high-risk population. TRIAL REGISTRATION: NCT01643473 on 16 July 2012.

title: A practice-based randomized controlled trial to improve medication adherence among Latinos with XXXX : study protocol for a randomized controlled trial.

answer: @entity1


abstract: INTRODUCTION: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. We present a case of @entity2 ( @entity2 ) of the submandibular gland with possible involvement of IgG4-RD. PRESENTATION OF CASE: The @entity0 was a 59-year-old @entity0 presenting with a swollen right submandibular gland. Laboratory tests revealed IgG4 levels of 176mg/dl (reference range: 4.8-105). An initial open biopsy for histological diagnosis showed @entity3 . The region was monitored on an outpatient basis, and finally the right submandibular was totally resected because @entity1 could not be excluded. Histological examination of the submandibular gland showed an @entity2 with lymphocytic infiltration containing many IgG4-positive plasma cells in the @entity1 stroma. DISCUSSION: We have described a case that indicated a possible involvement of @entity2 with IgG4-RD. This allows us to speculate that longstanding IgG4-RD may progress to @entity1 or infiltration of IgG4-positive plasma cells through the signals of @entity1 stimuli. Further investigations are required to determine the potential pathogenic mechanism underlying this unique @entity1 . CONCLUSION: This case underscores that caution is needed in the diagnosis of masses with high serum IgG4 levels, as the differential diagnosis includes @entity1 .

title: A case of XXXX associated with IgG4-related disease.

answer: @entity2


abstract: UNASSIGNED: Background and study aims: Endoscopic submucosal dissection (ESD) is widely used in the resection of @entity3 en bloc, however, complications such as @entity2 frequently occur following the procedure. The study aim was to elucidate the incidence, clinical characteristics, and risk factors of post-ESD @entity2 . @entity0 and methods: We conducted a retrospective cohort study of 471 consecutive @entity0 with 485 @entity4 resected by ESD between December 2005 and 2010. Pyrexia was defined as body temperature above 37.5  C, regardless of its duration. Blood tests and chest radiography were performed three times before and after ESD. Chest and abdominal computed tomography (CT) was taken on postoperative day 1. Results: Post-ESD @entity2 developed in 117 @entity0 (24.8%), including 40 @entity0 with @entity1 as shown by computed tomography. The @entity2 was resolved in all the @entity0 after 1 day (median; range, 1-36 days). A multivariate analysis identified age (P=0.0029) and resection diameter (P=0.0009) as risk factors for @entity2 in @entity0 without @entity1 , and operation time (P=0.0025) as a risk factor for @entity2 in @entity0 with @entity1 . Conclusion: The @entity0 would be at risk for post-ESD @entity2 if a large ESD is performed in the elderly. The longer operation time would raise the risk for @entity1 -associated fever.

title: Risk factors for XXXX after endoscopic submucosal dissection of @entity4 .

answer: @entity2


abstract: UNASSIGNED: Background and study aims: Endoscopic submucosal dissection (ESD) is widely used in the resection of @entity3 en bloc, however, complications such as @entity2 frequently occur following the procedure. The study aim was to elucidate the incidence, clinical characteristics, and risk factors of post-ESD @entity2 . @entity0 and methods: We conducted a retrospective cohort study of 471 consecutive @entity0 with 485 @entity4 resected by ESD between December 2005 and 2010. Pyrexia was defined as body temperature above 37.5  C, regardless of its duration. Blood tests and chest radiography were performed three times before and after ESD. Chest and abdominal computed tomography (CT) was taken on postoperative day 1. Results: Post-ESD @entity2 developed in 117 @entity0 (24.8%), including 40 @entity0 with @entity1 as shown by computed tomography. The @entity2 was resolved in all the @entity0 after 1 day (median; range, 1-36 days). A multivariate analysis identified age (P=0.0029) and resection diameter (P=0.0009) as risk factors for @entity2 in @entity0 without @entity1 , and operation time (P=0.0025) as a risk factor for @entity2 in @entity0 with @entity1 . Conclusion: The @entity0 would be at risk for post-ESD @entity2 if a large ESD is performed in the elderly. The longer operation time would raise the risk for @entity1 -associated fever.

title: Risk factors for @entity2 after endoscopic submucosal dissection of XXXX .

answer: @entity4


abstract: IMPORTANCE: @entity3 ( @entity3 ) and meta-analyses of @entity6 ( @entity6 ) for the treatment of @entity1 ( @entity1 ) have shown a modest clinical benefit compared with placebo. Furthermore, indirect comparison by meta-analyses showed that subcutaneous immunotherapy is more effective than @entity6 . Despite these data, @entity6 has become the most prescribed treatment of @entity1 in Europe in recent years, and it was approved by the US Food and Drug Administration for the treatment of @entity1 to grass pollen in the United States on April 1, 2014. OBJECTIVE: To assess the efficacy and safety of the grass pollen sublingual tablets licensed as drugs in the treatment of @entity0 with @entity1 to grass pollen. DATA SOURCES: Computerized bibliographic searches of MEDLINE, EMBASE, the Cochrane Library, and ClinicalTrials.gov (from inception to April 30, 2014) were supplemented with a manual search of reference lists. STUDY SELECTION: @entity3 were included if they compared the grass pollen @entity6 tablets approved by regulatory authorities in the European Union and the United States for @entity1 with placebo. DATA EXTRACTION AND SYNTHESIS: Data on populations, interventions, and outcomes were extracted from each RCT according to the intent-to-treat method by 2 independent observers and were combined using the method by DerSimonian and Laird. MAIN OUTCOMES AND MEASURES: The primary end point was the difference in the symptom score and medication score between @entity6 and placebo. We pooled data using random-effects meta-analysis, with standardized mean differences (SMDs) and 95% CIs reported. RESULTS: Data were available in 13 @entity3 for the symptom score (4659 @entity0 ) and in 12 @entity3 for the medication score (4558 @entity0 ). We found a small treatment benefit in the symptom score ( @entity5 , -0.28; 95% CI, -0.37 to -0.19; P   <   .001) and in the medication score ( @entity5 , -0.24; 95% CI, -0.31 to -0.17; P   <   .001). Adverse events were reported in 1384 of 2259 @entity0 (61.3%) receiving @entity6 and in 477 of 2279 @entity0 (20.9%) receiving placebo. Seven @entity0 in the @entity6 group reported treatment-related adverse events requiring @entity4 . CONCLUSIONS AND RELEVANCE: Findings show a small benefit of the grass pollen sublingual tablets in reducing symptoms and in decreasing the use of symptomatic medication (antihistamines and @entity2 ) in @entity0 with @entity1 . Considering the low magnitude of the benefit, the convenience and easy administration do not seem to be sufficient reasons for the choice of @entity6 .

title: Efficacy of Grass Pollen Allergen Sublingual Immunotherapy Tablets for XXXX : A Systematic Review and Meta-analysis.

answer: @entity1


abstract: UNASSIGNED: Aims: @entity1 ( @entity1 ) increases the risk of @entity4 ( @entity4 ). While motor functions worsen continuously, the assignment of @entity0 to @entity4 occurs categorically. It is unknown how many @entity0 are already sufficiently severely impaired to be categorised as @entity4 yet do not have an officially acknowledged level of @entity4 . Methods: A random sample of 1   449 @entity1 outpatients was clinically characterised by office-based neurologists, including impairments of activities of daily living (ADL with the Unified @entity1 Rating scale (UPDRS subscale II) as well as regarding the presence of @entity2 according to DSM-IV criteria and the Mini-Mental State Exam (MMSE). @entity3 was screened for with the Montgomery-Asberg @entity3 Rating Scale (MADRS). For each @entity0 the officially acknowledged level of @entity4 was documented; for @entity0 without official @entity4 level, the clinician appraised whether the @entity0 was care-dependent anyhow. Results: 266 @entity0 (18.3%) were officially acknowledged as care-dependent, while n=121 @entity0 (8.5%) were not, yet were appraised to be care-dependent according to the clinician. Compared to non- @entity4 @entity0 , they differed on every measure considered. Compared to @entity0 with an official @entity4 , their @entity1 duration was significantly shorter (6.0 vs. 8.0 years, p<0.01) and they were less severely impaired in ADL (13.3 vs. 15.5, p<0.01). They did not differ regarding the rates of @entity2 (52.9 vs. 44.9%, p=0.203) or @entity3 according to the MADRS (13.1 vs. 13.1, p=0.989). Conclusions: ADL impairments are the most important predictor for @entity4 while @entity2 and @entity3 are not considered despite the impairments that are additionally caused by them.

title: [Care-Dependency in XXXX : More Frequent than Assumed?]

answer: @entity1


abstract: OBJECTIVE: To analyze clinical and neuroimaging data in @entity0 with @entity5 and @entity1 as the only manifestation of the internal carotid artery (ICA) dissection ( @entity7 ) and vertebral artery (VA) dissection (VAD). MATERIAL AND METHODS: One hundred and sixty-one @entity0 (mean age - 37,4  4,99 years, 84 @entity0 , 52%) with @entity6 ( @entity6 ) verified by magnetic resonance imaging (MRI) were enrolled. @entity5 and @entity1 were the only @entity6 manifestation in 33 @entity0 (mean age 37,3  7,4 yars, 28 @entity0 , 85%). RESULTS: The localization of the dissections in these @entity0 was the following: one VA (15 @entity0 ), two VA (9), one ICA (7), two ICA (1), one ICA + two VA (1). The whole number of dissected arteries was 45: extracranial localization - 38, extra- intracranial - 6, intracranial - 1. Dissection led to stenosis of the arterial lumen in 41 arteries, to @entity3 - in 2 and to dual lumen in 2 arteries. Small aneurism was found in 4 arteries. Combination of @entity5 was observed in 26 out of 33 @entity0 (79%), the only @entity1 in 4 @entity0 , the only @entity5 in 3 @entity0 . Along with this, 9 out of 24 VAD @entity0 had the shoulder and/or arm @entity2 . @entity1 in VAD @entity0 was located more often in the occipital region (18 out of 24) that had never been observed in @entity7 @entity0 (p=0.0009). Fronto-temporal @entity2 was observed more often in @entity7 @entity0 (5 out of 8 @entity0 ) than in VAD (2 out of 24 @entity0 ) (p=0.003). @entity5 in all VAD @entity0 in comparison with 3 out of 8 @entity7 @entity0 had posterior localization (  =0,007). @entity5 was observed in 4 out of 8 @entity7 @entity0 and in no @entity0 with VAD (  =0.0009). The @entity2 appearance was abrupt in all @entity7 @entity0 and most of the VAD @entity0 . In 8 VAD @entity0 the @entity2 has been increasing during several hours. The @entity2 intensity was severe in 19 @entity0 , moderate in 12 and mild in 2. The characteristics of the @entity2 were as following: constrictive/dull (26 @entity0 ), throbbing (1 @entity0 ) or combined (6 @entity0 ). @entity2 was increasing in a stepwise manner during the first days in 14 out of 24 VAD @entity0 and in no one of @entity7 @entity0 (  =0.008). The @entity2 duration period was 31,8   15,7 days. @entity2 relief drugs were ineffective or had a short effect in 97% of @entity0 . CONCLUSION: @entity2 is more characteristic for @entity0 with VAD. @entity2 is presented as a combination of @entity1 and @entity5 . @entity2 localization, mode of appearance and the course are different in VAD and @entity7 . The rarity of @entity3 among @entity0 with " @entity2 -only" manifestation let to suggest that the intramural @entity4 in this group of @entity0 spreads to the adventitia that can reflect media weakness. Arterial wall changes underlying its weakness seem to be sex-hormone dependent taking into consideration the high predominance of @entity0 in @entity6 manifested by @entity2 .

title: [ @entity5 and XXXX as the only manifestation of @entity6 ].

answer: @entity1


abstract: OBJECTIVE: To analyze clinical and neuroimaging data in @entity0 with @entity5 and @entity1 as the only manifestation of the internal carotid artery (ICA) dissection ( @entity7 ) and vertebral artery (VA) dissection (VAD). MATERIAL AND METHODS: One hundred and sixty-one @entity0 (mean age - 37,4  4,99 years, 84 @entity0 , 52%) with @entity6 ( @entity6 ) verified by magnetic resonance imaging (MRI) were enrolled. @entity5 and @entity1 were the only @entity6 manifestation in 33 @entity0 (mean age 37,3  7,4 yars, 28 @entity0 , 85%). RESULTS: The localization of the dissections in these @entity0 was the following: one VA (15 @entity0 ), two VA (9), one ICA (7), two ICA (1), one ICA + two VA (1). The whole number of dissected arteries was 45: extracranial localization - 38, extra- intracranial - 6, intracranial - 1. Dissection led to stenosis of the arterial lumen in 41 arteries, to @entity3 - in 2 and to dual lumen in 2 arteries. Small aneurism was found in 4 arteries. Combination of @entity5 was observed in 26 out of 33 @entity0 (79%), the only @entity1 in 4 @entity0 , the only @entity5 in 3 @entity0 . Along with this, 9 out of 24 VAD @entity0 had the shoulder and/or arm @entity2 . @entity1 in VAD @entity0 was located more often in the occipital region (18 out of 24) that had never been observed in @entity7 @entity0 (p=0.0009). Fronto-temporal @entity2 was observed more often in @entity7 @entity0 (5 out of 8 @entity0 ) than in VAD (2 out of 24 @entity0 ) (p=0.003). @entity5 in all VAD @entity0 in comparison with 3 out of 8 @entity7 @entity0 had posterior localization (  =0,007). @entity5 was observed in 4 out of 8 @entity7 @entity0 and in no @entity0 with VAD (  =0.0009). The @entity2 appearance was abrupt in all @entity7 @entity0 and most of the VAD @entity0 . In 8 VAD @entity0 the @entity2 has been increasing during several hours. The @entity2 intensity was severe in 19 @entity0 , moderate in 12 and mild in 2. The characteristics of the @entity2 were as following: constrictive/dull (26 @entity0 ), throbbing (1 @entity0 ) or combined (6 @entity0 ). @entity2 was increasing in a stepwise manner during the first days in 14 out of 24 VAD @entity0 and in no one of @entity7 @entity0 (  =0.008). The @entity2 duration period was 31,8   15,7 days. @entity2 relief drugs were ineffective or had a short effect in 97% of @entity0 . CONCLUSION: @entity2 is more characteristic for @entity0 with VAD. @entity2 is presented as a combination of @entity1 and @entity5 . @entity2 localization, mode of appearance and the course are different in VAD and @entity7 . The rarity of @entity3 among @entity0 with " @entity2 -only" manifestation let to suggest that the intramural @entity4 in this group of @entity0 spreads to the adventitia that can reflect media weakness. Arterial wall changes underlying its weakness seem to be sex-hormone dependent taking into consideration the high predominance of @entity0 in @entity6 manifested by @entity2 .

title: [ XXXX and @entity1 as the only manifestation of @entity6 ].

answer: @entity5


abstract: OBJECTIVE: To analyze clinical and neuroimaging data in @entity0 with @entity5 and @entity1 as the only manifestation of the internal carotid artery (ICA) dissection ( @entity7 ) and vertebral artery (VA) dissection (VAD). MATERIAL AND METHODS: One hundred and sixty-one @entity0 (mean age - 37,4  4,99 years, 84 @entity0 , 52%) with @entity6 ( @entity6 ) verified by magnetic resonance imaging (MRI) were enrolled. @entity5 and @entity1 were the only @entity6 manifestation in 33 @entity0 (mean age 37,3  7,4 yars, 28 @entity0 , 85%). RESULTS: The localization of the dissections in these @entity0 was the following: one VA (15 @entity0 ), two VA (9), one ICA (7), two ICA (1), one ICA + two VA (1). The whole number of dissected arteries was 45: extracranial localization - 38, extra- intracranial - 6, intracranial - 1. Dissection led to stenosis of the arterial lumen in 41 arteries, to @entity3 - in 2 and to dual lumen in 2 arteries. Small aneurism was found in 4 arteries. Combination of @entity5 was observed in 26 out of 33 @entity0 (79%), the only @entity1 in 4 @entity0 , the only @entity5 in 3 @entity0 . Along with this, 9 out of 24 VAD @entity0 had the shoulder and/or arm @entity2 . @entity1 in VAD @entity0 was located more often in the occipital region (18 out of 24) that had never been observed in @entity7 @entity0 (p=0.0009). Fronto-temporal @entity2 was observed more often in @entity7 @entity0 (5 out of 8 @entity0 ) than in VAD (2 out of 24 @entity0 ) (p=0.003). @entity5 in all VAD @entity0 in comparison with 3 out of 8 @entity7 @entity0 had posterior localization (  =0,007). @entity5 was observed in 4 out of 8 @entity7 @entity0 and in no @entity0 with VAD (  =0.0009). The @entity2 appearance was abrupt in all @entity7 @entity0 and most of the VAD @entity0 . In 8 VAD @entity0 the @entity2 has been increasing during several hours. The @entity2 intensity was severe in 19 @entity0 , moderate in 12 and mild in 2. The characteristics of the @entity2 were as following: constrictive/dull (26 @entity0 ), throbbing (1 @entity0 ) or combined (6 @entity0 ). @entity2 was increasing in a stepwise manner during the first days in 14 out of 24 VAD @entity0 and in no one of @entity7 @entity0 (  =0.008). The @entity2 duration period was 31,8   15,7 days. @entity2 relief drugs were ineffective or had a short effect in 97% of @entity0 . CONCLUSION: @entity2 is more characteristic for @entity0 with VAD. @entity2 is presented as a combination of @entity1 and @entity5 . @entity2 localization, mode of appearance and the course are different in VAD and @entity7 . The rarity of @entity3 among @entity0 with " @entity2 -only" manifestation let to suggest that the intramural @entity4 in this group of @entity0 spreads to the adventitia that can reflect media weakness. Arterial wall changes underlying its weakness seem to be sex-hormone dependent taking into consideration the high predominance of @entity0 in @entity6 manifested by @entity2 .

title: [ @entity5 and @entity1 as the only manifestation of XXXX ].

answer: @entity6


abstract: The salutary effect of @entity3 and tissue perfusion on extending the ischemic tolerance of the @entity0 latissimus dorsi myocutaneous flap was demonstrated in this experimental study. A total of 175 flaps from 89 adult mongrel @entity0 were elevated with one-half the flaps perfused with iced Collins renal preservation solution. With the exception of control flaps kept at ambient temperature, the remaining flaps were stored at 4 degrees C for periods ranging from 24 to 192 hours followed by transplantation into the groins of recipient @entity0 , with @entity1 of the thoracodorsal artery and vein in an end-to-side manner to the femoral artery and vein, respectively. The study was divided into two distinct sections. The acute phase involved the transplantation of 77 flaps into random recipient @entity0 , and following a 3-hour period of systemic perfusion, the flaps were removed, weighed, and sectioned for later histologic study. Progressive increase in flap weight was observed up to 96 hours of @entity3 with a sharp decline in weight at 120 hours of @entity3 . The increase in flap weight in the nonperfused flaps was significantly greater than the previously perfused flaps. Histologically, at 120 hours of @entity3 , @entity2 was noted, suggestive of a no-reflow phenomenon. In the second, or extended-flap, study, 98 flaps were transplanted into the groins of the original donor animal and allowed to remain in situ for a 2-week period. The flaps were then carefully observed for viability, removed, and sectioned for histologic study. Hypothermic support of up to 96 hours extended viability in both perfused and nonperfused flaps, although beyond this hypothermic period viability was seen only in previously perfused flaps. The clinical implications of this study include hypothermic perfusion of a major-extremity amputation prior to replantation or the temporary storage of a free myocutaneous flap.

title: The effect of XXXX and tissue perfusion on extended myocutaneous flap viability.

answer: @entity3


abstract: BACKGROUND: Conventional cerebrospinal fluid diversion such as ventriculoperitoneal or ventriculoatrial shunting for the management of @entity5 is one of the commonest neurosurgical procedures. However, in selected @entity0 , surgical options are limited when relative contraindications for these operations exist. A @entity0 who underwent ventriculosternal shunting, a novel procedure, is presented with durable and successful outcomes. OBJECTIVE: To demonstrate the feasibility, durability, and safety of ventriculosternal shunting for the management of @entity5 . METHODS: A @entity0 with @entity1 and @entity3 with recurrent @entity4 suffered from post-subarachnoid @entity2 communicating @entity5 . Because of the need for continuous ambulatory peritoneal dialysis and the risk of introducing excessive cardiac preloading, conventional shunting was relatively contraindicated. Ventriculosternal shunting was performed by adopting the cancellous matrix of the sternum as the anatomic receptacle for intraosseous cerebrospinal fluid absorption. After placement of the ventricular catheter in the usual manner, the distal end was inserted into the sternum. RESULTS: There was demonstrable clinical and radiological improvement in @entity5 by ventriculosternal shunting. Cerebrospinal fluid intraosseous absorption by this novel procedure translated into both physical and cognitive recovery. The procedure was tolerable, effective, and durable, with the @entity0 suffering no complications 3 years after the procedure. CONCLUSION: Ventriculosternal shunting for the management of @entity5 is a feasible, safe, and durable surgical treatment option for selected @entity0 when conventional procedures are contraindicated. ABBREVIATION: VS, ventriculosternalThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

title: Ventriculosternal Shunting for the Management of XXXX : Case Report of A Novel Technique.

answer: @entity5


abstract: UNASSIGNED: Systematic analyses of gender effects in @entity3 are currently lacking, partly because sex and gender have not been used as stratification criteria in major studies on the topic. It is, however, indisputable that @entity1 differ in risk factors, incidence and prognosis between the genders. This review summarises the most important findings on differences related to biological sex and sociocultural gender and discusses anatomic specifics with immediate significance for surgical interventions. Epidemiological differences in upper @entity3 are most prominent in regard to histological subtypes, directly affecting diagnostics, therapy, and prognosis. @entity0 have a better prognosis in many of these @entity1 subtypes. For @entity2 , sex hormones, specifically oestrogens, appear to play a distinct role in tumourigenesis. Histopathological analysis of the expression of @entity7 receptor beta ( @entity6 ) in the @entity1 tissue has attracted interest since it was shown that @entity0 with low @entity6 expression have a better prognosis than @entity0 with comparable @entity6 status. Data on the higher incidence of right-sided @entity4 and @entity1 in @entity0 could lead to improved screening programmes. @entity0 and @entity0 cite differing reasons for avoidance of screening colonoscopies, thus gender specific approaches could improve @entity4 prevention programmes. Data on differing bioavailability of @entity5 between the genders are useful to minimise adverse effects of chemotherapy and should be accounted for in dosage. Further systematic analysis of gender effects on @entity1 is warranted and would be a substantial step towards personalised oncological surgery.

title: [Gender Aspects in XXXX and Their Prognosis in Regard to Multimodal Treatment Concepts].

answer: @entity1


abstract: BACKGROUND: @entity5 induced by @entity9 ( @entity9 ) has gained much attention. However, very limited numbers of studies have focused on the clinical significance of TG elevation in non- @entity9 induced @entity5 , such as @entity4 ( @entity4 ). This study aimed to study the clinical significances of @entity3 (TG) elevation in @entity0 with @entity4 . METHODS: We retrospectively analyzed a total of 426 @entity4 cases in our research center. According to the highest TG level within 72  h of disease onset, the @entity0 were divided into a normal TG group and an elevated TG group. We analyzed the differences between the two groups of @entity0 in aspects such as general information, disease severity, @entity8 (acute physiology and chronic health evaluation II) and Ranson scores, inflammatory cytokines, complications and prognosis. RESULTS: Compared with the normal TG group, @entity0 in the elevated TG group showed a significantly higher body mass index and were significantly younger. TG elevation at the early stage of @entity4 was associated with higher risk of severe @entity5 and @entity6 , especially @entity7 . For @entity0 with severe @entity5 , those with elevated TG levels were more likely to have a larger area of @entity1 , and higher incidence of @entity5 as well as higher mortality (17.78% versus 9.80%, P   <   0.05). CONCLUSIONS: In @entity4 @entity0 , TG elevation might participate in the aggravation of @entity5 and the occurrence of @entity2 . Thus, the TG level may serve as an important indicator to determine the prognosis of @entity0 with @entity4 .

title: Clinical significance of serum XXXX elevation at early stage of @entity4 .

answer: @entity3


abstract: BACKGROUND: @entity5 induced by @entity9 ( @entity9 ) has gained much attention. However, very limited numbers of studies have focused on the clinical significance of TG elevation in non- @entity9 induced @entity5 , such as @entity4 ( @entity4 ). This study aimed to study the clinical significances of @entity3 (TG) elevation in @entity0 with @entity4 . METHODS: We retrospectively analyzed a total of 426 @entity4 cases in our research center. According to the highest TG level within 72  h of disease onset, the @entity0 were divided into a normal TG group and an elevated TG group. We analyzed the differences between the two groups of @entity0 in aspects such as general information, disease severity, @entity8 (acute physiology and chronic health evaluation II) and Ranson scores, inflammatory cytokines, complications and prognosis. RESULTS: Compared with the normal TG group, @entity0 in the elevated TG group showed a significantly higher body mass index and were significantly younger. TG elevation at the early stage of @entity4 was associated with higher risk of severe @entity5 and @entity6 , especially @entity7 . For @entity0 with severe @entity5 , those with elevated TG levels were more likely to have a larger area of @entity1 , and higher incidence of @entity5 as well as higher mortality (17.78% versus 9.80%, P   <   0.05). CONCLUSIONS: In @entity4 @entity0 , TG elevation might participate in the aggravation of @entity5 and the occurrence of @entity2 . Thus, the TG level may serve as an important indicator to determine the prognosis of @entity0 with @entity4 .

title: Clinical significance of serum @entity3 elevation at early stage of XXXX .

answer: @entity4


abstract: OBJECTIVE: This study tested the new @entity3 severity criterion for @entity4 ( @entity4 ) based on frequency of @entity5 in a clinical sample. This study also tested overvaluation of shape/weight as an alternative severity specifier. METHOD: @entity0 were 834 treatment-seeking adults diagnosed with @entity3 @entity4 using semi-structured diagnostic and @entity2 interviews. @entity0 sub-grouped based on @entity3 severity levels and on overvaluation of shape/weight were compared on demographic and clinical variables. RESULTS: Based on @entity3 severity definitions, 331 (39.7%) @entity0 were categorized as mild, 395 (47.5%) as moderate, 83 (10.0%) as severe, and 25 (3.0%) as extreme. Analyses comparing three (mild, moderate, and severe/extreme) severity groups revealed no significant differences in demographic variables or body mass index (BMI). Analyses revealed significantly higher @entity2 psychopathology in the severe/extreme than moderate and mild groups and higher @entity1 in moderate and severe/extreme groups than the mild group; effect sizes were small. @entity0 characterized with overvaluation (N  =  449; 54%) versus without overvaluation (N  =  384; 46%) did not differ significantly in age, sex, BMI, or @entity5 frequency, but had significantly greater @entity2 psychopathology and @entity1 . The robustly greater @entity2 psychopathology and @entity1 levels (medium-to-large effect sizes) in the overvaluation group was observed without attenuation of effect sizes after adjusting for ethnicity/race and @entity5 severity/frequency. CONCLUSIONS: Our findings provide support for overvaluation of shape/weight as a severity specifier for @entity4 as it provides stronger information about the severity of homogeneous groupings of @entity0 than the @entity3 rating based on @entity5 .

title: Evaluation of the @entity3 severity indicator for XXXX in a clinical sample.

answer: @entity4