abstract: BACKGROUND: @entity1 ( @entity1 ) is a common clinical condition characterized by abrupt cardiovascular autonomic changes resulting in @entity2 . This is a recurring condition with mixed results from current strategies of treatment. METHODS: Subjects with a diagnosis of @entity1 were screened and enrolled. All the @entity0 were given a DVD containing yoga videos and were instructed to practice yoga therapy for 60  min, three times a week for 3 consecutive months. Syncope functional status questionnaire score (SFSQS) was administered at the beginning and the end of the study. The subjects were followed for 3  months and underwent repeat tilt table testing at the end of the study. RESULTS: Of the 60 @entity0 screened, 44 subjects were enrolled, 21 in the intervention group and 23 in the control group. Most of the @entity0 were females, and the mean age was 21        3  years. In the intervention group, who finished the yoga regimen, there was a statistically significant improvement from control phase to the intervention phase, in number of episodes of @entity2 (4        1 vs 1.3        0.7, p   <   0.001) and @entity2 (4.7        1.5 vs 1.5        0.5, p   <   0.001). The mean SFSQS also decreased from 67        7.8 to 29.8        4.6 (p   <   0.001). All subjects had positive head up tilt table (HUTT) study at the time of enrollment compared to only six @entity0 at the completion of intervention phase (10/100 vs 6/28  %, p   <   0.0001). CONCLUSION: Yoga therapy can potentially improve the symptoms of @entity2 and @entity2 in young female @entity0 with @entity1 .

title: Role of yoga as an adjunctive therapy in XXXX with @entity1 : a pilot study.

answer: @entity0


abstract: OBJECTIVE: We evaluated the significance of the power Doppler ultrasonography (PDUS) score by comparing it with serum biomarkers and clinical disease activity. METHODS: We measured the PDUS scores of 24 synovial sites in 12 joints in 22 @entity2 @entity0 . For convenience, the PDUS scores of six synovial sites in six joints were also examined. Each joint was scored for a power Doppler (PD) signal on a scale from 0 to 3. The PDUS scores are the sums of the PD signal scores for the 24 synovial sites or the 6 synovial sites. On the same day, serum variables as well as clinical disease activity were evaluated. RESULTS: The PDUS scores from the 24 joint sites were significantly positively correlated with DAS of 28 joints (DAS-28), simplified disease activity index (SDAI), clinical disease activity index (CDAI) and serum biomarkers including @entity3 , @entity1 and @entity4 ( @entity4 ). Accordingly, the PDUS scores from the six synovial sites greatly correlated with those from the 24 joint sites. Clinical disease activities as well as serum variables were also clearly correlated with the PDUS scores from the six synovial sites. CONCLUSION: The standard as well as the simplified PDUS scores well reflected clinical disease activity and serum variables, including angiogenic factors. Our data reaffirm the utility of ultrasonography for monitoring disease activity in @entity0 with @entity2 .

title: The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease activity and level of serum biomarkers in @entity0 with XXXX .

answer: @entity2


abstract: OBJECTIVE: We evaluated the significance of the power Doppler ultrasonography (PDUS) score by comparing it with serum biomarkers and clinical disease activity. METHODS: We measured the PDUS scores of 24 synovial sites in 12 joints in 22 @entity2 @entity0 . For convenience, the PDUS scores of six synovial sites in six joints were also examined. Each joint was scored for a power Doppler (PD) signal on a scale from 0 to 3. The PDUS scores are the sums of the PD signal scores for the 24 synovial sites or the 6 synovial sites. On the same day, serum variables as well as clinical disease activity were evaluated. RESULTS: The PDUS scores from the 24 joint sites were significantly positively correlated with DAS of 28 joints (DAS-28), simplified disease activity index (SDAI), clinical disease activity index (CDAI) and serum biomarkers including @entity3 , @entity1 and @entity4 ( @entity4 ). Accordingly, the PDUS scores from the six synovial sites greatly correlated with those from the 24 joint sites. Clinical disease activities as well as serum variables were also clearly correlated with the PDUS scores from the six synovial sites. CONCLUSION: The standard as well as the simplified PDUS scores well reflected clinical disease activity and serum variables, including angiogenic factors. Our data reaffirm the utility of ultrasonography for monitoring disease activity in @entity0 with @entity2 .

title: The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease activity and level of serum biomarkers in XXXX with @entity2 .

answer: @entity0


abstract: INTRODUCTION: The incidence of @entity2 in newborns has increased with the use of central venous catheters. Thrombolysis with recombinant @entity6 (rTPA) has been used as an alternative to @entity7 in life threatening @entity4 . The aim of this study is to describe the response and complications related to the use of rTPA in the management of life- threatening @entity2 in newborns. @entity0 AND METHOD: The medical records of 8 newborn were reviewed in a retrospective study, of whom 7 were preterm with @entity2 , and rTPA was used in all of them. RESULTS: The @entity0 included 4 males with a mean weight of 1580 gr. The principal pathology was @entity1 (7/8), all of them used venous central catheter. The superior vena cava was the most frequent location, with a mean time of installation before the diagnosis of 12 days. RN 7/8 thrombi were located in the right atrium with a size between 7 to 20 mm. Three @entity0 received low molecular weight heparin prior to using rTPA. They received between 1 to 5 cycles with rTPA. In 4 @entity0 complete resolution of the @entity3 was achieved in a mean of 3.5 days. Four @entity0 had @entity5 grade I, without sequelae at follow-up. There were no deaths or @entity4 . CONCLUSION: This study is the first series of @entity0 treated with rTPA in Chile, and where its use has quickly achieved complete resolution of the @entity3 in 50% of cases, and partially in the others, thus reducing the secondary life-threatening risk of this disease.

title: [Recombinant XXXX for the management of intracardiac thrombi in newborns].

answer: @entity6


abstract: Air and light pollution contribute to fetal abnormalities, increase prevalence of @entity1 , metabolic and @entity3 , and central nervous system (CNS) disorders. A component of air pollution, particulate matter, and the phenomenon of dim light at night ( @entity10 ) both result in neuroinflammation, which has been implicated in several @entity9 . The combinatorial role of these pollutants on health outcomes has not been assessed. Male C3H/HeNHsd @entity2 , with intact @entity6 production, were used to model @entity0 exposed to circadian disruption by @entity10 and contaminated environmental air. We hypothesized exposure to 2.5  m of particulate matter (PM2.5) and @entity10 (5lx) combines to upregulate neuroinflammatory cytokine expression and alter hippocampal morphology compared to @entity2 exposed to filtered air (FA) and housed under dark nights (LD). We also hypothesized that exposure to PM2.5 and @entity10 provokes @entity5 . For four weeks, four groups of @entity2 were simultaneously exposed to ambient concentrated PM2.5 or FA and/or @entity10 or LD. Following exposure, @entity2 underwent several behavioral assays and hippocampi were collected for qPCR and morphological analyses. Our results are generally comparable to previous PM2.5 and @entity10 reports conducted on @entity2 and implicate PM2.5 and @entity10 as potential factors contributing to @entity5 and @entity4 . Short-term exposure to PM2.5 and @entity10 upregulated neuroinflammatory cytokines and altered @entity8 hippocampal structural changes, as well as provoked @entity5 -like responses ( @entity7 ). However, combined, PM2.5 and @entity10 exposure did not have additive effects, as hypothesized, suggesting a ceiling effect of neuroinflammation may exist in response to multiple pollutants.

title: Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd XXXX .

answer: @entity2


abstract: UNASSIGNED: Spiradenocarcinoma is a @entity6 with potential for aggressive behavior, classified histologically into low- and high-grade @entity2 . Morphologically, low-grade @entity2 are thought to behave more favorably. Limited information is available, however, with only 18 published cases. To study their clinical behavior, histological features, and the diagnostic value of immunohistochemistry, 19 morphologically low-grade spiradenocarcinomas were retrieved and compared with 21 spiradenomas and @entity7 . H_E-stained sections were reviewed, follow-up was obtained, and immunohistochemistry for Ki-67, @entity4 and, @entity8 was performed. The @entity2 were solitary, measuring 0.8-7   cm (median: 2.7   cm), with a predilection for the head and neck of elderly @entity0 (median age: 72 years; range 53-92) without gender bias. Histologically, the @entity2 were multinodular and located in deep dermis and subcutis. A pre-existing spiradenoma was present in all cases. The malignant component was characterized by expansile growth with loss of the dual cell population, up to moderate cytological atypia and increased mitotic activity (median: 10/10 HPF; range 1-28). Additional findings included squamoid differentiation (n=9), @entity3 (n=7), and @entity5 (n=5). @entity4 expression was variable and no significant differences were noted in the benign compared with the malignant parts of the @entity2 . In contrast, in the malignant components the Ki-67 proliferative index was slightly increased, and @entity8 expression was lost. Follow-up (median: 67 months; range: 13-132) available for 16 @entity0 (84%) revealed a local recurrence rate of 19% but no @entity1 or disease-related mortality. In this large study with long-term follow-up, we demonstrate that spiradenocarcinomas with low-grade morphology pursue an indolent course, characterized by local recurrence only. @entity1 and disease-related mortality appear to be exceptional. Lack of @entity8 expression may be useful as an additional aid in the diagnosis of these challenging @entity2 .

title: Morphologically low-grade spiradenocarcinoma: a clinicopathologic study of 19 cases with emphasis on outcome and XXXX expression.

answer: @entity8


abstract: UNASSIGNED: The @entity4 or @entity3 to the @entity6 often results in a @entity8 for prosthetic tooth rehabilitation. This study evaluated the use of @entity5 mesh and recombinant @entity0 @entity7 (rhBMP-2) for the repair of major @entity2 in the alveolar bone. Five @entity0 were enrolled in the study; these @entity0 required implant replacements for two contiguous missing teeth in the @entity6 , which lacked sufficient bone. Residual ridges were augmented with rhBMP-2 and @entity5 mesh to direct the geometry of the newly formed bone. Seven months later, a bone biopsy specimen was removed from the implantation site before osteotomy and insertion of dental implants. Cone beam computed tomography (CBCT) scans were obtained preoperatively, postoperatively (baseline), and 48 months after implantation to evaluate implant healing. All dental implants were placed in the grafted sites without the need for further bone augmentation. The most frequent adverse effects were @entity1 . Biopsy specimens were used to evaluate bone quality. CBCT scans provided a prediction of alveolar restoration and long-term success. The combination of rhBMP-2 and @entity5 mesh provided effective augmentation of the @entity6 prior to implant placement.

title: Bone augmentation of the @entity6 for dental implants using rhBMP-2 and XXXX mesh: histological and tomographic analysis.

answer: @entity5


abstract: UNASSIGNED: The @entity4 or @entity3 to the @entity6 often results in a @entity8 for prosthetic tooth rehabilitation. This study evaluated the use of @entity5 mesh and recombinant @entity0 @entity7 (rhBMP-2) for the repair of major @entity2 in the alveolar bone. Five @entity0 were enrolled in the study; these @entity0 required implant replacements for two contiguous missing teeth in the @entity6 , which lacked sufficient bone. Residual ridges were augmented with rhBMP-2 and @entity5 mesh to direct the geometry of the newly formed bone. Seven months later, a bone biopsy specimen was removed from the implantation site before osteotomy and insertion of dental implants. Cone beam computed tomography (CBCT) scans were obtained preoperatively, postoperatively (baseline), and 48 months after implantation to evaluate implant healing. All dental implants were placed in the grafted sites without the need for further bone augmentation. The most frequent adverse effects were @entity1 . Biopsy specimens were used to evaluate bone quality. CBCT scans provided a prediction of alveolar restoration and long-term success. The combination of rhBMP-2 and @entity5 mesh provided effective augmentation of the @entity6 prior to implant placement.

title: Bone augmentation of the XXXX for dental implants using rhBMP-2 and @entity5 mesh: histological and tomographic analysis.

answer: @entity6


abstract: INTRODUCTION: Use of disease-modifying anti-rheumatic drugs (DMARDs) in @entity5 ( @entity5 ) may prevent @entity2 and potentially reduce joint replacement surgeries. We assessed the association between @entity5 drug use and joint replacement in Quebec, Canada. METHODS: A cohort of new-onset @entity5 @entity0 was identified from Quebec's physician billing and hospitalization databases from 2002-2011. The outcome was defined using procedure codes submitted by orthopedic surgeons. Medication use was obtained from pharmacy databases. We used alternative Cox regression models with time-dependent variables measuring the cumulative effects of past use during different time windows (one model focussing on the first year after cohort entry) for @entity6 ( @entity8 ), and other DMARDs. Models were adjusted for baseline sociodemographics, co-morbidity and prior health service use, time-dependent cumulative use of other drugs (anti- @entity1 @entity3 factor [anti-TNF] agents, other biologics, @entity7 inhibitors [COXIBs], nonselective nonsteroidal antiinflammatory drugs [NSAIDs], and systemic @entity4 ), and markers of disease severity. RESULTS: During follow-up, 608 joint replacements occurred among 11,333 @entity0 (median follow-up: 4.6  years). The best-fitting model relied on the cumulative early use (within the first year after cohort entry) of @entity8 and of other DMARDs, with an interaction between @entity8 and other DMARDs. In this model, greater exposure within the first year, to either @entity8 (adjusted hazard ratio, HR   =   0.95 per 1  month, 95  % confidence interval, 95  % CI 0.93-0.97) or other DMARDs (HR   =   0.97, 95 % CI 0.95-0.99) was associated with longer time to joint replacement. CONCLUSIONS: Our results suggest that longer exposure to either @entity6 ( @entity8 ) or other DMARDs within the first year after @entity5 diagnosis is associated with longer time to joint replacement surgery.

title: Early medication use in new-onset XXXX may delay joint replacement: results of a large population-based study.

answer: @entity5


abstract: PURPOSE: To present the experience of repairing iatrogenic @entity2 ( @entity2 ) using a rotational bladder flap and peritoneal interposition technique. METHODS: Between January 2009 and June 2014, a total of 18 @entity0 (mean age, 44.0 years; age range, 29-51 years) with @entity2 were treated using a transperitoneal approach. All @entity2 were complications of gynecologic procedures. Twelve @entity0 experienced recurrent @entity2 and one @entity0 had a concomitant @entity3 after radiotherapy. The @entity1 was approached transabdominally. The peritoneum covering the bladder was isolated to expose the bladder and prepare for the interposition. The bladder was opened along the sagittal plane to the @entity1 and a bladder flap was rotated downward to fill the @entity1 defect. The vaginal defect was closed, then a flap using the isolated peritoneum was interposed and fixed between the vagina and bladder. A ureteral re-implantation was performed in one @entity0 . All VVF procedures were performed by one urologist (SW). Repair of the @entity3 was performed by a general surgeon at the same time. RESULTS: Seventeen @entity0 (success rate   =   94% [100% for primary cases and 92% for recurrent cases]) had no evidence of recurrent VVF at a mean follow-up of 20 months (range, 6-36 months). The only @entity0 who had previously undergone a repair procedure failed. CONCLUSIONS: A transperitoneal approach with the use of a rotational bladder flap and peritoneal interposition might be a feasible and reliable procedure for surgical management of iatrogenic @entity2 , especially in complicated cases. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Repair of complex XXXX by combining a rotational bladder flap and full thick vascular peritoneal interposition.

answer: @entity2


abstract: BACKGROUND: Mortality in early stage, resectable @entity1 is sufficiently high to warrant consideration of post-surgical treatment. Novel markers to stratify resectable @entity1 @entity0 may help with the selection of treatment to improve outcome. METHODS: Primary @entity2 tissue from 485 @entity0 , surgically treated for stage I-II @entity3 , was analysed for the RNA expression of 31 cell cycle progression (CCP) genes by quantitative polymerase chain reaction (PCR). The expression average, the CCP score, was combined with pathological stage into a prognostic score (PS). Cox proportional hazards regression assessed prediction of 5-year @entity1 mortality above clinical variables. The PS threshold was tested for risk discrimination by the Mantel-Cox log-rank test. RESULTS: The CCP score added significant information above clinical markers (all @entity0 , P=0.0029; stage I @entity0 , P=0.013). The prognostic score was a superior predictor of outcome compared to pathological stage alone (PS, P=0.00084; stage, P=0.24). Five-year @entity1 mortality was significantly different between the low-risk (90%, 95% confidence interval (CI) 81-95%), and high-risk groups (65%, 95% CI 57-72%), P=4.2*10(-6)). CONCLUSIONS: The CCP score is an independent prognostic marker in early stage @entity3 . The prognostic score provides superior risk estimates than stage alone. The threefold higher risk in the high-risk group defines a subset of @entity0 that should consider therapeutic choices to improve outcome.

title: Stratification of resectable XXXX by molecular and pathological risk estimators.

answer: @entity3


abstract: BACKGROUND: The aim of this study was to analyzed the characteristics and treatment of @entity7 in the elder @entity0 with @entity7 in central China. MATERIAL AND METHODS: We retrospectively analyzed the characteristics and treatment of @entity7 in the @entity0 over the age of 60 to analyze the trends and clinical characteristics of maxillofacial @entity3 in elder @entity0 from the First Affiliated Hospital of Zhengzhou University (from 2010 to 2013) in central China and to present recommendations on prevention and management. RESULTS: Of the 932 @entity0 with @entity7 , 126 aged over 60 years old accounting for 13.52% of all the @entity0 (male:female, 1.74:1; mean age, 67.08 years old). Approximately 52% of the @entity0 were injured by falls. The most frequently observed type of injuries was soft tissue injuries (100%), followed by @entity4 (83.05%). Of the @entity0 with soft tissue injuries, the abrasions accounted the most, followed by lacerations. The numbers of @entity0 of midface @entity4 (60 @entity0 ) were almost similar to the number of lower face @entity4 (66 @entity0 ). Eighty two @entity0 (65.08%%) demonstrated associated injuries, of which @entity5 were the most prevalent. One hundred and four @entity0 (82.54%) had other systemic medical conditions, with @entity1 the most and followed by @entity2 . Furthermore, the study indicated a relationship between maxillofacial @entity4 and @entity2 . Only 13 @entity0 (10.32%) sustained local infections, of whom had other medical conditions. Most of the @entity6 (85.71%) in older @entity0 were operated including debridement, fixing loose teeth, reduction, intermaxillary fixation and open reduction and internal fixation (ORIF). CONCLUSIONS: Our analysis of the characteristics of @entity7 in the elder patents may help to promote clinical research to develop more effective treatment and possibly prevent such injuries.

title: Analysis of 126 hospitalized elder maxillofacial XXXX victims in central China.

answer: @entity3


abstract: OBJECTIVE: Although imaging surveillance is mandatory for all @entity0 after @entity3 repair (EVAR), many @entity0 are not compliant with follow-up. We sought to determine predictors of compliance with EVAR surveillance and to examine how compliance with current surveillance protocols correlates with survival. METHODS: We analyzed 188 @entity0 who underwent EVAR at our institution for @entity4 (AAAs) between 2001 and 2011. The primary end point was compliance with post-EVAR surveillance recommendations. Univariate analysis included @entity0 demographics and socioeconomic information, AAA characteristics, EVAR hospital course variables, late complications and secondary interventions, length of follow-up, smoking status, family history of AAA, driving distances, primary care providers, and medical comorbidities. Mortality was determined by the Social Security Death Index. Multinomial logistic regressions were fit to identify independent predictors of compliance. Survival plots were generated with the Kaplan-Meier method and compared with the log-rank test. Univariate and multivariate Cox regression analysis was used to determine effect of compliance on survival after adjusting for confounders. RESULTS: Of 188 @entity0 , 89 (47.3%) were 100% compliant with follow-up visits and imaging, 21 (11.1%) were moderately compliant by missing appointments, and 78 (41.4%) were lost to follow-up completely. Overall median age was 74  years, and 81.9% of @entity0 were male. Late complications occurred in 77 @entity0 (40.9%), secondary interventions were performed in 32 @entity0 (17%), and 5-year mortality was 21.2%. Mean follow-up interval was >40  months for 100% compliant and moderately compliant @entity0 and  <20  months for those lost to follow-up (P  < .0001). In adjusted analysis, late complications (odds ratio [OR], 2.71; 95% confidence interval [CI], 1.32-5.55; P  = .007), @entity5 (OR, 2.43; 95% CI, 1.12-5.27; P  = .024), and family history of AAA (OR, 2.67; 95% CI, 1.06-6.75; P  = .037) were associated with 100% compliance, whereas shorter driving distances (P  = .051) and shorter hospital stay (P  = .056) approached significance. Transient @entity1 attack or @entity2 (OR, 3.59; 95% CI, 1.18-10.91; P  = .024) was the only variable independently associated with moderate compliance. Compared with @entity0 lost to follow-up, 100% compliant @entity0 had worse survival (log-rank test, P  = .033), whereas moderately compliant @entity0 ' survival was not significantly different (log-rank test, P  = .149). In adjusted Cox regression analysis, 100% compliant @entity0 had decreased survival duration (rate ratio, 2.67; 95% CI, 1.18-6.06; P  = .018) compared with those lost to follow-up. CONCLUSIONS: Follow-up surveillance is incomplete for more than half of @entity0 who undergo EVAR at our institution, and @entity0 compliance can be predicted by covariates mentioned before. Compliance with current surveillance regimens does not confer a survival benefit. Further research individualizing surveillance protocols based on risk level of late complications and noncompliance and prospective studies examining resulting survival benefits of compliance are warranted.

title: Predictors of compliance with surveillance after XXXX repair and comparative survival outcomes.

answer: @entity3


abstract: BACKGROUND: Pareidolia, which is a particular type of complex @entity2 , has been reported to be a phenomenon analogous to @entity8 in @entity0 with @entity3 with @entity7 . However, whether pareidolia is observed in @entity1 ( @entity1 ) or whether there are common underlying mechanisms of these two types of @entity2 remains to be elucidated. METHODS: A test to evoke pareidolia, the Pareidolia test, was administered to 53 @entity0 with @entity1 without @entity3 and 24 healthy controls. The regional cerebral metabolic rate of @entity5 was measured using @entity6 positron emission tomography in the @entity1 @entity0 . RESULTS: @entity1 @entity0 without @entity3 produced a greater number of @entity9 compared with the controls. Pareidolia was observed in all of the @entity0 having @entity8 as well as a subset of those without @entity8 . The number of @entity9 was correlated with hypometabolism in the bilateral temporal, parietal and occipital cortices. The index of @entity8 was correlated with hypometabolism in the left parietal cortex. A region associated with both pareidolia and @entity8 was found in the left parietal lobe. CONCLUSIONS: Our study suggests that @entity1 @entity0 without @entity3 experience pareidolia more frequently than healthy controls and that posterior @entity4 could be a common neural mechanism of pareidolia and @entity8 . Pareidolia could represent subclinical @entity8 or a predisposition to @entity8 in @entity7 .

title: Pareidolia in XXXX without @entity3 : A positron emission tomography study.

answer: @entity1


abstract: BACKGROUND: Pareidolia, which is a particular type of complex @entity2 , has been reported to be a phenomenon analogous to @entity8 in @entity0 with @entity3 with @entity7 . However, whether pareidolia is observed in @entity1 ( @entity1 ) or whether there are common underlying mechanisms of these two types of @entity2 remains to be elucidated. METHODS: A test to evoke pareidolia, the Pareidolia test, was administered to 53 @entity0 with @entity1 without @entity3 and 24 healthy controls. The regional cerebral metabolic rate of @entity5 was measured using @entity6 positron emission tomography in the @entity1 @entity0 . RESULTS: @entity1 @entity0 without @entity3 produced a greater number of @entity9 compared with the controls. Pareidolia was observed in all of the @entity0 having @entity8 as well as a subset of those without @entity8 . The number of @entity9 was correlated with hypometabolism in the bilateral temporal, parietal and occipital cortices. The index of @entity8 was correlated with hypometabolism in the left parietal cortex. A region associated with both pareidolia and @entity8 was found in the left parietal lobe. CONCLUSIONS: Our study suggests that @entity1 @entity0 without @entity3 experience pareidolia more frequently than healthy controls and that posterior @entity4 could be a common neural mechanism of pareidolia and @entity8 . Pareidolia could represent subclinical @entity8 or a predisposition to @entity8 in @entity7 .

title: Pareidolia in @entity1 without XXXX : A positron emission tomography study.

answer: @entity3


abstract: BACKGROUND: The purpose of this study was to investigate the relative contributions of two proposed mechanisms, strength imbalance and @entity2 , to @entity1 in a @entity0 model of @entity4 ( @entity4 ). METHODS: Thirty-two @entity0 pups were divided into four groups on the basis of surgical interventions to induce a strength imbalance, impaired growth, both a strength imbalance and impaired growth (a combined mechanism), and a sham condition in the left forelimb. Maximum passive external shoulder rotation angle (ERmax) was measured bilaterally at four and eight weeks postoperatively. After the @entity0 were killed at eight weeks, the glenohumeral geometry (on microcomputed tomography) and shoulder muscle architecture properties were measured bilaterally. RESULTS: Bilateral muscle mass and optimal length differences were greatest in the impaired growth and combined mechanism groups, which also exhibited >15   lower ERmax (p < 0.05; four weeks postoperatively), 14   to 18   more @entity3 (p < 0.10), and 0.76 to 0.94 mm more inferior humeral head translation (p < 0.10) on the affected side. Across all four groups, optimal muscle length was significantly correlated with at least one @entity1 measure for six of fourteen muscle compartments crossing the shoulder on the affected side (p < 0.05). In the strength imbalance group, the glenoid was 5   more inclined and the humeral head was translated 7.5% more posteriorly on the affected side (p < 0.05). CONCLUSIONS: @entity2 and @entity1 were most pronounced in the impaired growth and combined mechanism groups, which underwent neurectomy. Strength imbalance was associated with @entity1 to a lesser extent. CLINICAL RELEVANCE: Treatments to alleviate @entity1 should address mechanical effects of both strength imbalance and @entity2 , with an emphasis on developing new treatments to promote growth in muscles affected by @entity4 .

title: Biomechanical Basis of Shoulder Osseous Deformity and Contracture in a @entity0 Model of XXXX .

answer: @entity4


abstract: BACKGROUND: The purpose of this study was to investigate the relative contributions of two proposed mechanisms, strength imbalance and @entity2 , to @entity1 in a @entity0 model of @entity4 ( @entity4 ). METHODS: Thirty-two @entity0 pups were divided into four groups on the basis of surgical interventions to induce a strength imbalance, impaired growth, both a strength imbalance and impaired growth (a combined mechanism), and a sham condition in the left forelimb. Maximum passive external shoulder rotation angle (ERmax) was measured bilaterally at four and eight weeks postoperatively. After the @entity0 were killed at eight weeks, the glenohumeral geometry (on microcomputed tomography) and shoulder muscle architecture properties were measured bilaterally. RESULTS: Bilateral muscle mass and optimal length differences were greatest in the impaired growth and combined mechanism groups, which also exhibited >15   lower ERmax (p < 0.05; four weeks postoperatively), 14   to 18   more @entity3 (p < 0.10), and 0.76 to 0.94 mm more inferior humeral head translation (p < 0.10) on the affected side. Across all four groups, optimal muscle length was significantly correlated with at least one @entity1 measure for six of fourteen muscle compartments crossing the shoulder on the affected side (p < 0.05). In the strength imbalance group, the glenoid was 5   more inclined and the humeral head was translated 7.5% more posteriorly on the affected side (p < 0.05). CONCLUSIONS: @entity2 and @entity1 were most pronounced in the impaired growth and combined mechanism groups, which underwent neurectomy. Strength imbalance was associated with @entity1 to a lesser extent. CLINICAL RELEVANCE: Treatments to alleviate @entity1 should address mechanical effects of both strength imbalance and @entity2 , with an emphasis on developing new treatments to promote growth in muscles affected by @entity4 .

title: Biomechanical Basis of Shoulder Osseous Deformity and Contracture in a XXXX Model of @entity4 .

answer: @entity0


abstract: The constitutively expressed @entity2 protein 70 kDa ( @entity8 ) is a major chaperone protein responsible for maintaining @entity7 , yet how its structure translates into functional decisions regarding client fate is still unclear. We previously showed that @entity8 preserved aberrant Tau, but it remained unknown if selective inhibition of the activity of this @entity4 isoform could facilitate Tau clearance. Using single point mutations in the @entity6 binding domain, we assessed the effect of several mutations on the functions of @entity0 @entity8 . Biochemical characterization revealed that one mutation abolished both @entity8 ATPase and refolding activities. This variant resembled the @entity1 -bound conformer at all times yet remained able to interact with cofactors, @entity3 , and substrates appropriately, resembling a dominant negative @entity8 (DN- @entity8 ). We then assessed the effects of this DN- @entity8 on its client Tau. DN- @entity8 potently facilitated Tau clearance via the proteasome in cells and brain tissue, in contrast to wild type @entity8 that stabilized Tau. Thus, DN- @entity8 mimics the action of small molecule pan @entity4 inhibitors with regard to Tau metabolism. This shift in @entity8 function by a single point mutation was the result of a change in the chaperome associated with @entity8 such that DN- @entity8 associated more with @entity5 and DnaJ proteins, whereas wild type @entity8 was more associated with other @entity4 isoforms. Thus, isoform-selective targeting of @entity8 could be a viable therapeutic strategy for @entity9 and possibly lead to new insights in chaperone complex biology.

title: Isoform-selective Genetic Inhibition of Constitutive Cytosolic XXXX Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

answer: @entity4


abstract: The electrophysiologic effects and safety of @entity4 administered either intravenously or orally were studied in 14 @entity0 with @entity3 during orthodromic reentrant @entity1 and @entity2 ( @entity2 ). Anterograde and retrograde effective refractory periods of the accessory pathway did not change significantly from baseline during either i.v. or oral administration. Administration by either route prevented induction of sustained reentrant @entity1 in 8 @entity0 . In 6 @entity0 , the reentrant @entity1 was either nonsustained (2 @entity0 ) or sustained at much slower rates than the baseline rates (mean +/- standard deviation, baseline, 290 +/- 41 ms; i.v., 355 +/- 40 ms [p less than 0.001]; and oral, 377 +/- 33 ms [p less than 0.001]). In these @entity0 anterograde atrioventricular conduction was prolonged significantly from the mean baseline value of 163 +/- 36 ms to 212 +/- 35 ms with i.v. administration (p less than 0.005) and 225 +/- 33 ms with oral administration (p less than 0.005). Retrograde conduction via the accessory pathway did not change significantly after administration of @entity4 . The shortest preexcited RR intervals during @entity2 were significantly reduced during i.v. but not during oral administration: control, 327 +/- 47 ms; i.v., 270 +/- 28 ms (p less than 0.001); and oral, 323 +/- 44 ms (difference not significant). In 5 @entity0 @entity2 was sustained for a mean of 20 minutes after i.v. and for 12 minutes after oral administration (p less than 0.20), compared with a baseline mean value of 0.83 minute.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Efficacy and safety of intravenous and oral @entity4 for XXXX .

answer: @entity3


abstract: The electrophysiologic effects and safety of @entity4 administered either intravenously or orally were studied in 14 @entity0 with @entity3 during orthodromic reentrant @entity1 and @entity2 ( @entity2 ). Anterograde and retrograde effective refractory periods of the accessory pathway did not change significantly from baseline during either i.v. or oral administration. Administration by either route prevented induction of sustained reentrant @entity1 in 8 @entity0 . In 6 @entity0 , the reentrant @entity1 was either nonsustained (2 @entity0 ) or sustained at much slower rates than the baseline rates (mean +/- standard deviation, baseline, 290 +/- 41 ms; i.v., 355 +/- 40 ms [p less than 0.001]; and oral, 377 +/- 33 ms [p less than 0.001]). In these @entity0 anterograde atrioventricular conduction was prolonged significantly from the mean baseline value of 163 +/- 36 ms to 212 +/- 35 ms with i.v. administration (p less than 0.005) and 225 +/- 33 ms with oral administration (p less than 0.005). Retrograde conduction via the accessory pathway did not change significantly after administration of @entity4 . The shortest preexcited RR intervals during @entity2 were significantly reduced during i.v. but not during oral administration: control, 327 +/- 47 ms; i.v., 270 +/- 28 ms (p less than 0.001); and oral, 323 +/- 44 ms (difference not significant). In 5 @entity0 @entity2 was sustained for a mean of 20 minutes after i.v. and for 12 minutes after oral administration (p less than 0.20), compared with a baseline mean value of 0.83 minute.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Efficacy and safety of intravenous and oral XXXX for @entity3 .

answer: @entity4


abstract: OBJECTIVE: The current study aimed to analyze the short-term and long-term curative effects of @entity6 (NO) inhalation combined with high-frequency oscillatory ventilation (HFOV) on neonatal severe @entity5 . MATERIALS AND METHODS: A total of 98 neonates meeting the inclusion criteria were retrospectively analyzed. The control group comprised of 48 neonates and the NO inhalation group consisted of 50 neonates. In the control group, conventional mechanical ventilation was replaced by HFOV. In the experimental group, NO inhalation combined with HFOV was performed. The @entity2 rates within 28 days, mechanical ventilation and @entity1 therapy time, and complications in both groups were observed. The survivors in both groups were followed up for 18 months for neural development evaluation. RESULTS: The treatment group showed a significantly lower @entity2 rate and noticeably shorter mechanical ventilation and @entity1 therapy time than the control group (8% vs. 22.9% with t = 4.20 andp < 0.05; 5.84    3.36 days vs. 8.05    5.48 days with t = 2.42 and p < 0.05; and 8.02    4.31 days vs. 12.45    5.14 days with t = 4.63 and p < 0.001). They did not show significant differences with regards to the complications and the incidences of @entity4 , hearing and @entity3 , and severe @entity0 (p > 0.05). CONCLUSION: NO inhalation combined with HFOV significantly decreases the @entity2 rate of neonates with severe @entity5 and reduces their mechanical ventilation and @entity1 therapy time. It does not increase early adverse effects or affect long-term neurodevelopment.

title: Effect of @entity6 inhalation combined with high-frequency oscillatory ventilation on the prognosis of neonatal severe XXXX .

answer: @entity5


abstract: OBJECTIVE: The current study aimed to analyze the short-term and long-term curative effects of @entity6 (NO) inhalation combined with high-frequency oscillatory ventilation (HFOV) on neonatal severe @entity5 . MATERIALS AND METHODS: A total of 98 neonates meeting the inclusion criteria were retrospectively analyzed. The control group comprised of 48 neonates and the NO inhalation group consisted of 50 neonates. In the control group, conventional mechanical ventilation was replaced by HFOV. In the experimental group, NO inhalation combined with HFOV was performed. The @entity2 rates within 28 days, mechanical ventilation and @entity1 therapy time, and complications in both groups were observed. The survivors in both groups were followed up for 18 months for neural development evaluation. RESULTS: The treatment group showed a significantly lower @entity2 rate and noticeably shorter mechanical ventilation and @entity1 therapy time than the control group (8% vs. 22.9% with t = 4.20 andp < 0.05; 5.84    3.36 days vs. 8.05    5.48 days with t = 2.42 and p < 0.05; and 8.02    4.31 days vs. 12.45    5.14 days with t = 4.63 and p < 0.001). They did not show significant differences with regards to the complications and the incidences of @entity4 , hearing and @entity3 , and severe @entity0 (p > 0.05). CONCLUSION: NO inhalation combined with HFOV significantly decreases the @entity2 rate of neonates with severe @entity5 and reduces their mechanical ventilation and @entity1 therapy time. It does not increase early adverse effects or affect long-term neurodevelopment.

title: Effect of XXXX inhalation combined with high-frequency oscillatory ventilation on the prognosis of neonatal severe @entity5 .

answer: @entity6


abstract: The incidence and severity of abnormalities of the coronary arteries were evaluated in 35 necropsy @entity0 with @entity5 and an intact @entity1 . Right ventricular to coronary artery fistulous connections were found in more than 60% of the cases. All @entity0 with fistulous connections had histologic abnormalities of the coronary arteries. In 50% the lesions were mild, with medial and intimal thickening producing up to moderate @entity4 . In 50% there was loss of normal arterial wall structure and severe @entity3 or obliteration of the arterial lumen. The coronary arterial fistulas and histologic abnormalities were prevalent in those with underdevelopment of the tricuspid valve and right ventricular cavity but were not found in @entity0 with a normal or dilated tricuspid valve anulus. The @entity2 were found in more than 80% of @entity0 with a tricuspid valve/mitral valve ratio less than 1. A single coronary artery occurred in 6 @entity0 (17%) of this series. In 80% of those with 1 coronary artery arising from the other, the aberrantly arising coronary artery crossed anteriorly to the pulmonary artery and could be at risk in surgical attempts to reconstruct the right ventricular outflow. Aortography is recommended if the coronary arteries are not clearly delineated on @entity1 .

title: @entity2 in @entity5 with intact XXXX .

answer: @entity1


abstract: The incidence and severity of abnormalities of the coronary arteries were evaluated in 35 necropsy @entity0 with @entity5 and an intact @entity1 . Right ventricular to coronary artery fistulous connections were found in more than 60% of the cases. All @entity0 with fistulous connections had histologic abnormalities of the coronary arteries. In 50% the lesions were mild, with medial and intimal thickening producing up to moderate @entity4 . In 50% there was loss of normal arterial wall structure and severe @entity3 or obliteration of the arterial lumen. The coronary arterial fistulas and histologic abnormalities were prevalent in those with underdevelopment of the tricuspid valve and right ventricular cavity but were not found in @entity0 with a normal or dilated tricuspid valve anulus. The @entity2 were found in more than 80% of @entity0 with a tricuspid valve/mitral valve ratio less than 1. A single coronary artery occurred in 6 @entity0 (17%) of this series. In 80% of those with 1 coronary artery arising from the other, the aberrantly arising coronary artery crossed anteriorly to the pulmonary artery and could be at risk in surgical attempts to reconstruct the right ventricular outflow. Aortography is recommended if the coronary arteries are not clearly delineated on @entity1 .

title: @entity2 in XXXX with intact @entity1 .

answer: @entity5


abstract: The incidence and severity of abnormalities of the coronary arteries were evaluated in 35 necropsy @entity0 with @entity5 and an intact @entity1 . Right ventricular to coronary artery fistulous connections were found in more than 60% of the cases. All @entity0 with fistulous connections had histologic abnormalities of the coronary arteries. In 50% the lesions were mild, with medial and intimal thickening producing up to moderate @entity4 . In 50% there was loss of normal arterial wall structure and severe @entity3 or obliteration of the arterial lumen. The coronary arterial fistulas and histologic abnormalities were prevalent in those with underdevelopment of the tricuspid valve and right ventricular cavity but were not found in @entity0 with a normal or dilated tricuspid valve anulus. The @entity2 were found in more than 80% of @entity0 with a tricuspid valve/mitral valve ratio less than 1. A single coronary artery occurred in 6 @entity0 (17%) of this series. In 80% of those with 1 coronary artery arising from the other, the aberrantly arising coronary artery crossed anteriorly to the pulmonary artery and could be at risk in surgical attempts to reconstruct the right ventricular outflow. Aortography is recommended if the coronary arteries are not clearly delineated on @entity1 .

title: XXXX in @entity5 with intact @entity1 .

answer: @entity2


abstract: OBJECTIVE: To demonstrate the utility of electromyography (EMG) in the evaluation and management of treatment-resistant @entity4 . METHOD: We report a case of @entity4 in which EMG was used to identify and treat isolated cricothyroid (CT) @entity2 . RESULTS: The @entity0 , a healthy 43-year-old @entity0 , presented with 9  months of progressive hoarseness. Her symptoms were present across vocal tasks but were particularly bothersome while dictating. On presentation, her voice was rated grade 3, roughness 3, breathiness 1, asthenia 0, and strain 3 (G3R3B1A0S3). Videostroboscopy was remarkable for @entity3 . Voice therapy was not beneficial despite appropriate effort. Microdirect laryngoscopy revealed no evidence of structural pathology. The @entity0 was referred for EMG because of her normal examination and failure to improve with therapy. The CT muscle demonstrated an increased latency of 750  ms in all vocal tasks. One month after CT injection with 3 units of botulinum toxin (BTX), her voice was improved. Perceptual voice evaluation was rated G1R1B0A0S1. Voice Handicap Index improved from 87 to  35. CONCLUSIONS: In the absence of structural pathology, EMG can be a useful adjunct in the diagnosis of @entity4 that persists despite adequate trials of voice therapy. To our knowledge, this is the only report of @entity2 due to isolated @entity1 successfully treated with BTX.

title: XXXX Due to Isolated @entity2 .

answer: @entity4


abstract: OBJECTIVE: To demonstrate the utility of electromyography (EMG) in the evaluation and management of treatment-resistant @entity4 . METHOD: We report a case of @entity4 in which EMG was used to identify and treat isolated cricothyroid (CT) @entity2 . RESULTS: The @entity0 , a healthy 43-year-old @entity0 , presented with 9  months of progressive hoarseness. Her symptoms were present across vocal tasks but were particularly bothersome while dictating. On presentation, her voice was rated grade 3, roughness 3, breathiness 1, asthenia 0, and strain 3 (G3R3B1A0S3). Videostroboscopy was remarkable for @entity3 . Voice therapy was not beneficial despite appropriate effort. Microdirect laryngoscopy revealed no evidence of structural pathology. The @entity0 was referred for EMG because of her normal examination and failure to improve with therapy. The CT muscle demonstrated an increased latency of 750  ms in all vocal tasks. One month after CT injection with 3 units of botulinum toxin (BTX), her voice was improved. Perceptual voice evaluation was rated G1R1B0A0S1. Voice Handicap Index improved from 87 to  35. CONCLUSIONS: In the absence of structural pathology, EMG can be a useful adjunct in the diagnosis of @entity4 that persists despite adequate trials of voice therapy. To our knowledge, this is the only report of @entity2 due to isolated @entity1 successfully treated with BTX.

title: @entity4 Due to Isolated XXXX .

answer: @entity2


abstract: Five @entity0 were allotted to each of six treatments on a matched-individual basis. Treatments were none, sham, total adrenalectomy with adrenocorticoid replacement, intravenous @entity5 (15 mg X kg-1 X day-1), adrenalectomy + @entity5 , and adrenal medullectomy. The conscious @entity0 were bled 20 ml/kg over 5 min. @entity4 (6 mg/kg) was injected intravenously. The responses of arterial pressure and of plasma @entity3 (E) and @entity2 (NE) concentrations were measured. Factorial analysis was used to calculate the effects of sympathetic noradrenergic nerves (SYM) and the adrenal medulla (ADR) on the responses. In combination, SYM + ADR fully accounted for the pressor response observed in normal and sham-treated @entity0 . SYM and ADR each made independent and approximately equal contributions to the response, but the SYM X ADR interaction was strongly antagonistic. The responses of plasma E and NE were fully accounted for by the adrenal glands and sympathetic nerves, respectively. The pressor responses after total adrenalectomy and adrenal medullectomy were similar. Thus @entity1 -stimulated adrenal corticosteroid release was not essential to @entity4 's action, and adrenal enkephalins were not responsible for @entity4 's action on sympathetic pathways.

title: Sympathoadrenal mechanisms in cardiovascular responses to XXXX after @entity1 .

answer: @entity4


abstract: Five @entity0 were allotted to each of six treatments on a matched-individual basis. Treatments were none, sham, total adrenalectomy with adrenocorticoid replacement, intravenous @entity5 (15 mg X kg-1 X day-1), adrenalectomy + @entity5 , and adrenal medullectomy. The conscious @entity0 were bled 20 ml/kg over 5 min. @entity4 (6 mg/kg) was injected intravenously. The responses of arterial pressure and of plasma @entity3 (E) and @entity2 (NE) concentrations were measured. Factorial analysis was used to calculate the effects of sympathetic noradrenergic nerves (SYM) and the adrenal medulla (ADR) on the responses. In combination, SYM + ADR fully accounted for the pressor response observed in normal and sham-treated @entity0 . SYM and ADR each made independent and approximately equal contributions to the response, but the SYM X ADR interaction was strongly antagonistic. The responses of plasma E and NE were fully accounted for by the adrenal glands and sympathetic nerves, respectively. The pressor responses after total adrenalectomy and adrenal medullectomy were similar. Thus @entity1 -stimulated adrenal corticosteroid release was not essential to @entity4 's action, and adrenal enkephalins were not responsible for @entity4 's action on sympathetic pathways.

title: Sympathoadrenal mechanisms in cardiovascular responses to @entity4 after XXXX .

answer: @entity1


abstract: The role of sympathetic efferent innervation of the carotid sinus on the regulation of baroreceptor sensitivity was examined in thiopental- @entity2 anesthetized @entity1 (5 mg X kg-1 X h-1 infusion). Baroreflex sensitivity was defined as the slope of renal sympathetic efferent nerve activity vs. carotid sinus pressure in an isolated, perfused carotid sinus. Slopes were obtained before and after sinus sympathectomy performed by section of the cervical sympathetic trunk. There was no significant differences between baroreflex decreases in renal sympathetic activity due to increases in carotid sinus pressure before and after sympathectomy, but the responses to decreases in carotid sinus pressure after sympathectomy were significantly greater than control. Base-line level of renal sympathetic activity, obtained at a constant perfusion pressure of 115 mmHg, abruptly increased by 11% in response to sinus sympathectomy. The response of baroreceptors to sympathomimetic stimulation was examined by recording carotid baroreceptor afferent nerve activity during ramp changes in carotid sinus pressure after addition of @entity3 (10(-8) to 10(-6) M) to the perfusate of the sympathetically denervated sinus. The slopes of the sinus nerve activity vs. carotid sinus pressure were used as direct indexes of baroreceptor sensitivity. Lower levels of @entity3 (10(-8), 10(-7) M) increased the sensitivity of the baroreceptors and reduced @entity0 back toward presympathectomy levels. A higher dose of @entity3 (10(-6) M) did not significantly increase baroreceptor sensitivity. The results of this study suggest that sinus sympathetic fibers produce a tonic sensitization of the baroreceptors.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of sympathetic sensitization of baroreceptors on XXXX .

answer: @entity0


abstract: OBJECTIVES: This goal of this paper is to describe the reach, application, and effectiveness of an 8-week yoga therapy protocol with older @entity1 survivors within a Veterans Health Administration setting. METHODS: To document the reach of this intervention, recruitment efforts, attendance, and practice rates were tracked. To explore the application of the protocol to this population, physical therapy preassessment and observations by the yoga therapist were recorded to ascertain necessary pose modifications. Effectiveness was measured through pre- and post-course structured interviews, tracking self-reported symptoms of combat-related @entity6 , @entity5 , @entity3 , @entity7 , @entity2 , and @entity4 . RESULTS: Regarding reach, 15% of eligible veterans (n = 14) enrolled, participated in 3-16 classes (M  SD = 11.64  3.39), and practiced at home for 0-56 days (M  SD = 26.36  17.87). @entity0 were primarily Caucasian (n = 13), male (n = 13), ranged in age from 55 to 78 years (M  SD = 65.64  5.15), and had multiple medical problems. During application, substantial individualized modifications to the yoga therapy protocol were necessary. Effectiveness of the intervention was mixed. During post-course interviews, @entity0 reported a variety of qualitative benefits. Notably, the majority of @entity0 reported that breathing and relaxation techniques were the most useful to learn. Group comparisons of mean pre- and post-course scores on standardized measures showed no significant differences. CONCLUSIONS: A minority of older veterans express an interest in yoga, but those who do have high rates of class attendance and home practice. Careful physical pre-assessment and attentive therapists are required to undertake the adaptations required by @entity0 with multiple comorbidities. The effectiveness of yoga in this setting requires additional study.

title: Implementing yoga therapy adapted for older veterans who are XXXX survivors.

answer: @entity1


abstract: BACKGROUND: Objective cost estimates and source of cost differences are needed across the spectrum of cognition, including cognitively normal (CN), @entity1 ( @entity1 ), newly discovered @entity3 , and prevalent @entity3 . METHODS: Subjects were a subset of the Mayo Clinic Study of Aging stratified-random sampling of Olmsted County, MN, residents aged 70 to 89  years. A neurologist reviewed provider-linked medical records to identify prevalent @entity3 (review date  =  index). Remaining subjects were invited to participate in prospective clinical/neuropsychological assessments; @entity0 were categorized as CN, @entity1 , or newly discovered @entity3 (assessment date  =  index). Costs for medical services/procedures 1-year pre-index (excluding indirect and long-term care costs) were estimated using line-item provider-linked administrative data. We estimated contributions of care-delivery site and comorbid conditions (including and excluding neuropsychiatric diagnoses) to between-category cost differences. RESULTS: Annual mean medical costs for CN, @entity1 , newly discovered @entity3 , and prevalent @entity3 were  6042,  6784,  9431,  11,678, respectively. Hospital inpatient costs contributed 70% of total costs for prevalent @entity3 and accounted for differences between CN and both prevalent and newly discovered @entity3 . Ambulatory costs accounted for differences between CN and @entity1 . Age-, sex-, education-adjusted differences reached significance for CN versus newly discovered and prevalent @entity3 and for @entity1 versus prevalent @entity3 . After considering all comorbid diagnoses, between-category differences were reduced (e.g., prevalent @entity3 minus @entity1 (from  4842 to  3575); newly discovered @entity3 minus CN (from  3578 to  711)). Following the exclusion of neuropsychiatric diagnoses from comorbidity adjustment, between-category differences tended to revert to greater differences. CONCLUSIONS: Cost estimates did not differ significantly between CN and @entity1 . Substantial differences between @entity1 and prevalent @entity3 reflected high inpatient costs for @entity3 and appear partly related to co-occurring @entity2 . Such comparisons can help inform models aimed at identifying where, when, and for which individuals proposed interventions might be cost-effective.

title: Direct medical costs and source of cost differences across the spectrum of XXXX : A population-based study.

answer: @entity1


abstract: OBJECTIVE: To observe the curative effect of acupoint-injection and intramuscular-injection of Bacillus Calmette-Guerin (BCG) Polysaccharide Nucleic Acid for @entity1 . METHODS: Sixty @entity0 with @entity1 were equally randomized into acupoint-injection group and intramuscular-injection group. For @entity0 of the acupoint-injection group, 2 mL of BCG was injected into bilateral Feishu (BL 13, 1 mL for one side) once per day in the first 15 days, and once every other day in the rest 2.5 months except weekends. Intramuscular-injection was conducted at the lateral sites of the left or right buttock, 2 mL/time for each site, and the injection frequency was the same to that of the acupoint-injection. The therapeutic effect was assessed according to the standards of Guide Principles for Clinical Research of New Chinese Herbal Drugs (2002) and Asthma Group of Breathing Diseases of China Medical Association (2008). Changes of FEV 1 (forced expiratory volume in the first second)/FVC (forced vital capacity) and PEF% (peak expiratory flow) were detected using a pulmonary function detector. Serum IgA, IgM, IgG and IgE contents were assayed by using an autonomic biochemical analyzer. RESULTS: After 3 months' treatment, the scores of @entity0 ' symptoms and signs and serum IgE and IgG levels were significantly decreased in both muscular-injection and acupoint-injection groups (P<0.01), while asthma controlled test (ACT) scores FEV 1/FVC% and PEF% values were considerably increased in both groups compared to pre-treatment in the same one group (P<0.01). The effects of acupoint-injection were markedly superior to those of the intramuscular-injection in reducing clinical symptom-sign score, and serum IgE content, and in up-regulating ACT score, FEV 1/FVC% and PEF% levels (P<0.05, P<0.01). There were no significant differences in serum IgG, IgA and IgM levels between the two groups 3 months following the treatment (P>0.05). CONCLUSION: Acupoint-injection of BCG polysaccharide nucleic acid can effectively improve @entity1 @entity0 ' clinical symptoms and sings and pulmonary function, which may be closely associated with its function in down-regulating serum IgE and IgG levels.

title: [Comparison of therapeutic effects between acupoint-injection and intramuscular-injection of Bacillus Calmette-Guerin polysaccharide nucleic acid for XXXX ].

answer: @entity1


abstract: OBJECTIVE: This study examines @entity0 factors to identify risks of 12-month mortality following periprosthetic @entity1 . Hospital charges were analyzed to quantify the financial burden for treatment modalities. METHODS: Data were retrospectively analyzed from a prospective database at a university hospital setting. One-hundred and thirteen @entity0 with a @entity3 of the proximal or distal femur were identified. Risk factors for 12-month mortality were analyzed, and financial data were compared between the various treatment modalities. RESULTS: In all, 14% of @entity0 died (16 of 113) within 3 months and the 1-year mortality was 17.7% (20 of 113). @entity0 who died within 1 year had higher hospital charges (US 33 880    25 051 vs US 22 886    16 841; P = .01) and were older (87.6    8.5 vs 81.5    8.6; P = .004). Logistic regression analysis revealed age was the only significant predictor of 1-year mortality (P = .029, odds ratio 1.1). Analysis of financial data revealed 4 distinct groups (P < .05 between groups). Distal femoral revision arthroplasty (RA-DF) generated the highest hospital charges of US 91 035    25 579 (n = 3). The second most highly charged group included proximal @entity2 treated with revision arthroplasty (US 34 078    17 832; n = 20) and hemi/total hip arthroplasty (THA; US 41 556    23 651; n = 8). The third most charged group underwent open reduction internal fixation of the proximal (US 18 706    6829; n = 35) and distal (US 22 381    10 835; n = 35) femur. Nonoperative treatment generated the lowest charges (US 6426    2899; n = 11). On average, the hospital lost money treating @entity0 with RA-DF (US -19 080    2022 per @entity0 ) and hemi/THA (US -6594    9305 per @entity0 ), while all other treatment groups were profitable. CONCLUSION: One-year mortality after periprosthetic @entity1 was 17.7%, is mostly influenced by age, and 80% of deaths occur within 3 months. @entity0 treated with primary/revision arthroplasty generate more hospital charges than internal fixation. The average @entity0 treated with revision arthroplasty of the distal femur or hemi/THA for a periprosthetic @entity1 resulted in net financial losses for the hospital.

title: Mortality and Financial Burden of XXXX of the Femur.

answer: @entity3


abstract: The elderly (age 70+) @entity0 with orthopedic @entity1 is a rapidly growing subset of @entity0 in the United States. Due to increased medical comorbidities and decreased physiological reserve, morbidity and mortality after @entity1 may significantly differ from those @entity0 younger than 70 years old. A retrospective review was performed to investigate the effect of age on orthopedic @entity1 . A total of 870 records of @entity0 with orthopedic @entity1 from 2006 to 2009 at our Level One @entity1 center were reviewed. A database was created to include demographics, type and number of comorbid conditions at presentation, injuries, intensive care unit (ICU) and hospital length of stay, and description of the @entity2 . @entity0 aged 70 years and older had an increased number of comorbidities per @entity0 (3.3214-P < .0001). Length of stay in @entity0 aged 70 years and older was not significantly greater than that of the younger @entity0 . They spent an average of 14.76 days in the hospital compared to 13.42 days for the combined younger @entity0 (P = .45), but they spent significantly (P < .0001) more of their stay in the ICU (52.74% vs 34.9% for the younger cohorts). The number of @entity2 per @entity0 was lower (1.66) in the 70 and older age-group when compared to younger populations (P < .0001). The 70 and older group was more likely to have their injury due to a fall and less likely to have solid organ injuries. As the number of elderly @entity0 increase, continued research in the management of elderly @entity0 with @entity1 can lead to protocols and practice guidelines to improve outcomes.

title: Orthopedic XXXX and Aging: It Isn't Just About Mortality.

answer: @entity1


abstract: STUDY OBJECTIVES: Cognitive behavioral therapy for @entity1 (CBT-I) has been shown to improve both @entity3 , but predictors of @entity3 outcome following CBT-I have not been well examined. This study investigated how chronotype (i.e., morningness- eveningness trait) and changes in @entity2 ( @entity2 ) were related to changes in @entity3 among recipients of CBT-I. METHODS: Included were 419 adult @entity1 outpatients from a @entity2 clinic (43.20% males, age M  SD = 48.14  14.02). All @entity0 completed the Composite Scale of Morningness and attended a 6-session group CBT-I up to the second last session. @entity2 was extracted from sleep diary; @entity3 were assessed using the Beck Depression Inventory (BDI) prior to (Baseline), and at the end (End) of intervention. RESULTS: Multilevel structural equation modeling revealed that from Baseline to End, @entity2 increased and BDI decreased significantly. Controlling for age, sex, BDI, and @entity2 at Baseline, stronger evening chronotype and less improvement in @entity2 significantly and uniquely predicted less reduction in BDI from Baseline to End. Chronotype did not predict improvement in @entity2 . CONCLUSIONS: In an @entity1 outpatient sample, @entity2 and @entity3 improved significantly after a CBT-I group intervention. All chronotypes benefited from sleep improvement, but those with greater eveningness and/or less sleep improvement experienced less reduction in @entity3 symptom severity. This suggests that evening preference and @entity1 may have distinct relationships with mood, raising the possibility that the effect of CBT-I on @entity3 could be enhanced by assessing and addressing circadian factors.

title: Chronotype and Improved Sleep Efficiency Independently Predict Depressive Symptom Reduction after Group Cognitive Behavioral Therapy for XXXX .

answer: @entity1


abstract: @entity7 were subjected to 12-15 min swimming exercise at 2/3 body lengths s-1 in a Blazka-type swim tunnel. @entity3 , cardiac output (ventral aortic blood flow) and heart rate were continuously recorded, and blood samples for measurement of arterial and mixed venous @entity0 tension were taken before and at the end of the exercise period. In a second group of fish, subjected to similar exercise regimes, blood samples were taken for analysis of the plasma concentrations of @entity5 . @entity3 and cardiac output increase during exercise, while the mixed venous @entity0 tension decreases. The effect on cardiac output is due to an increase of both heart rate and @entity1 volume. There are no significant changes in either @entity4 , or in the plasma concentrations of @entity5 . Injection of the adrenergic neurone-blocking drug @entity8 produces a @entity3 in resting cod, due to a decrease in the systemic vascular resistance. Exercising cod treated with @entity8 have a significantly lower pre- and postbranchial blood pressure than exercising control cod. This is due mainly to a dramatic reduction in the systemic vascular resistance. The alpha-adrenoceptor antagonist @entity6 does not further affect the blood pressure in cod treated with @entity8 . It is concluded that the exercise @entity2 observed in cod depends on the effect of adrenergic vasomotor fibres maintaining the systemic vascular resistance, and also on the increase in cardiac output. An adrenergic innervation of the heart may play some role in the control of cardiac performance both at rest and during exercise, but the main cardioregulatory mechanism is likely to be non-adrenergic, most probably including cardiac control via variation of the cholinergic vagal cardioinhibitory tonus.

title: Blood pressure control during exercise in the XXXX , @entity7 .

answer: @entity7


abstract: @entity7 were subjected to 12-15 min swimming exercise at 2/3 body lengths s-1 in a Blazka-type swim tunnel. @entity3 , cardiac output (ventral aortic blood flow) and heart rate were continuously recorded, and blood samples for measurement of arterial and mixed venous @entity0 tension were taken before and at the end of the exercise period. In a second group of fish, subjected to similar exercise regimes, blood samples were taken for analysis of the plasma concentrations of @entity5 . @entity3 and cardiac output increase during exercise, while the mixed venous @entity0 tension decreases. The effect on cardiac output is due to an increase of both heart rate and @entity1 volume. There are no significant changes in either @entity4 , or in the plasma concentrations of @entity5 . Injection of the adrenergic neurone-blocking drug @entity8 produces a @entity3 in resting cod, due to a decrease in the systemic vascular resistance. Exercising cod treated with @entity8 have a significantly lower pre- and postbranchial blood pressure than exercising control cod. This is due mainly to a dramatic reduction in the systemic vascular resistance. The alpha-adrenoceptor antagonist @entity6 does not further affect the blood pressure in cod treated with @entity8 . It is concluded that the exercise @entity2 observed in cod depends on the effect of adrenergic vasomotor fibres maintaining the systemic vascular resistance, and also on the increase in cardiac output. An adrenergic innervation of the heart may play some role in the control of cardiac performance both at rest and during exercise, but the main cardioregulatory mechanism is likely to be non-adrenergic, most probably including cardiac control via variation of the cholinergic vagal cardioinhibitory tonus.

title: Blood pressure control during exercise in the @entity7 , XXXX .

answer: @entity7


abstract: CONTEXT: Angelica sinensis (Oliv.) Diels (Apiaceae) polysaccharides ( @entity7 ) may play a key role in anti- @entity1 activity. However, the anti- @entity3 activity and mechanism are unknown. OBJECTIVE: This study investigated the protective effects of @entity7 against ox-LDL-induced senescence of EPCs and explored its underlying molecular mechanisms. MATERIALS AND METHODS: Mononuclear cells were isolated from bone marrow (BM) of SD @entity0 and differentiated to EPCs. EPCs were exposed to oxidized low-density lipoprotein (ox-LDL, 10     g/mL, 24   h) and incubated with or without high-dose (100     g/mL, 48   h) or low-dose (20     g/mL, 48   h) @entity7 . Another group of EPCs was pre-treated with @entity5 (100   nM, 45   min), a PI3K/ @entity6 inhibitor. EPC senescence, telomerase activity, and @entity2 anion levels were assessed using SA-b-galactosidase staining, telomerase PCR-ELISA analysis, and DHE staining, respectively. The expression of related proteins, including @entity6 , p- @entity6 , @entity4 , p- @entity4 , and @entity8 , were detected using western blot. RESULTS: EPCs (47.3%) were SA-b-gal positive after treatment by ox-LDL, additionally, ox-LDL significantly increased @entity2 anion levels (375% versus 100%), and inhibited telomerase activity (42% versus 100%). However, the pro-senescent effect of ox-LDL was attenuated about three-fold (16.7%), @entity2 anion levels were decreased more than two-fold (148%), and telomerase activity was recovered partly (88% versus 42%) in the EPCs when treated with @entity7 (100     g/mL). The immunoblotting confirmed that @entity7 attenuated inhibition of phosphorylation of @entity6 and @entity4 induced by ox-LDL and down-regulated increased the expression of gp91-phox. Moreover, some effects of @entity7 were partially abrogated in the presence of @entity5 . DISCUSSION: Ox-LDL induced senescence of EPCs via inhibition of telomerase activity, which was influenced by oxidative stress and the @entity6 / @entity4 pathway. The inhibition of EPC senescence by @entity7 could be important for potential therapeutics. CONCLUSION: Treatment of EPCs with @entity7 remarkably attenuates the harmful effects of ox-LDL via augmentation of @entity6 / @entity4 phosphorylation and inhibition of oxidative stress.

title: Angelica sinensis polysaccharides inhibit endothelial progenitor cell senescence through the reduction of oxidative stress and activation of the @entity6 / XXXX pathway.

answer: @entity4


abstract: CONTEXT: Angelica sinensis (Oliv.) Diels (Apiaceae) polysaccharides ( @entity7 ) may play a key role in anti- @entity1 activity. However, the anti- @entity3 activity and mechanism are unknown. OBJECTIVE: This study investigated the protective effects of @entity7 against ox-LDL-induced senescence of EPCs and explored its underlying molecular mechanisms. MATERIALS AND METHODS: Mononuclear cells were isolated from bone marrow (BM) of SD @entity0 and differentiated to EPCs. EPCs were exposed to oxidized low-density lipoprotein (ox-LDL, 10     g/mL, 24   h) and incubated with or without high-dose (100     g/mL, 48   h) or low-dose (20     g/mL, 48   h) @entity7 . Another group of EPCs was pre-treated with @entity5 (100   nM, 45   min), a PI3K/ @entity6 inhibitor. EPC senescence, telomerase activity, and @entity2 anion levels were assessed using SA-b-galactosidase staining, telomerase PCR-ELISA analysis, and DHE staining, respectively. The expression of related proteins, including @entity6 , p- @entity6 , @entity4 , p- @entity4 , and @entity8 , were detected using western blot. RESULTS: EPCs (47.3%) were SA-b-gal positive after treatment by ox-LDL, additionally, ox-LDL significantly increased @entity2 anion levels (375% versus 100%), and inhibited telomerase activity (42% versus 100%). However, the pro-senescent effect of ox-LDL was attenuated about three-fold (16.7%), @entity2 anion levels were decreased more than two-fold (148%), and telomerase activity was recovered partly (88% versus 42%) in the EPCs when treated with @entity7 (100     g/mL). The immunoblotting confirmed that @entity7 attenuated inhibition of phosphorylation of @entity6 and @entity4 induced by ox-LDL and down-regulated increased the expression of gp91-phox. Moreover, some effects of @entity7 were partially abrogated in the presence of @entity5 . DISCUSSION: Ox-LDL induced senescence of EPCs via inhibition of telomerase activity, which was influenced by oxidative stress and the @entity6 / @entity4 pathway. The inhibition of EPC senescence by @entity7 could be important for potential therapeutics. CONCLUSION: Treatment of EPCs with @entity7 remarkably attenuates the harmful effects of ox-LDL via augmentation of @entity6 / @entity4 phosphorylation and inhibition of oxidative stress.

title: Angelica sinensis polysaccharides inhibit endothelial progenitor cell senescence through the reduction of oxidative stress and activation of the XXXX / @entity4 pathway.

answer: @entity6


abstract: Twenty-six @entity1 with @entity0 were treated with intensive @entity4 (Adria Laboratories, Columbus, @entity6 ) as a single agent administered for three successive days once a month. Dosing started at 25 or 30 mg/m2/d three times, and was escalated by 5 mg/m2/d monthly to maximal tolerance based on hematologic, mucosal, or cardiac @entity3 . Four @entity1 (15%) had complete remissions (CRs) pathologically proven, and six others (23%) sustained complete CRs, but were found to have microscopic @entity2 (three) or refused biopsy (three). Twelve @entity1 (46%) attained partial remission (PR). The overall response (85%) and CR rates (38%) were approximately double those reported with conventional @entity4 doses. Median unmaintained remission duration for the ten @entity1 in CR was 11 months. @entity5 , determined by radionuclide physiologic studies, occurred in 16 @entity1 at a mean dose of 459 mg/m2; three @entity1 developed reversible congestive failure. There were no toxic deaths. The median overall survival was 18 months. These data suggest that there is steep dose responsiveness to @entity4 in @entity0 , and that more effective techniques for using @entity4 may exist than those conventionally used.

title: A phase I-II study of intensive-dose XXXX for advanced @entity0 .

answer: @entity4


abstract: Twenty-six @entity1 with @entity0 were treated with intensive @entity4 (Adria Laboratories, Columbus, @entity6 ) as a single agent administered for three successive days once a month. Dosing started at 25 or 30 mg/m2/d three times, and was escalated by 5 mg/m2/d monthly to maximal tolerance based on hematologic, mucosal, or cardiac @entity3 . Four @entity1 (15%) had complete remissions (CRs) pathologically proven, and six others (23%) sustained complete CRs, but were found to have microscopic @entity2 (three) or refused biopsy (three). Twelve @entity1 (46%) attained partial remission (PR). The overall response (85%) and CR rates (38%) were approximately double those reported with conventional @entity4 doses. Median unmaintained remission duration for the ten @entity1 in CR was 11 months. @entity5 , determined by radionuclide physiologic studies, occurred in 16 @entity1 at a mean dose of 459 mg/m2; three @entity1 developed reversible congestive failure. There were no toxic deaths. The median overall survival was 18 months. These data suggest that there is steep dose responsiveness to @entity4 in @entity0 , and that more effective techniques for using @entity4 may exist than those conventionally used.

title: A phase I-II study of intensive-dose @entity4 for advanced XXXX .

answer: @entity0


abstract: PURPOSE: The purpose was to describe the medial rectus muscle elongation (MRE) procedure to treat very large-angle @entity3 ( @entity3 ) with surgery on a lower number of muscles. METHODS: Twenty @entity0 with very large-angle @entity3 (more than 70 @entity2 ) underwent the MRE procedure. In the MRE procedure, the muscle was split longitudinally into three parts. The wider central part was sutured with 6/0 vicryl and disinserted. The distal end of the peripheral parts (still attached to the original insertion), 7-9  mm away from the insertion, was sutured to the proximal end of the central part. At the end of the procedure, the distance of the @entity1 site from the insertion was named as the final elongation. The dose-response effect of the final elongation was calculated in bilateral MRE cases. The mean of the dose-response effect, obtained in the binocular surgery group, was used in the monocular surgery group to calculate the resection effect of lateral rectus (LR) muscle. RESULTS: Eleven @entity0 underwent bilateral MRE and nine @entity0 underwent unilateral MRE and LR muscle resection. The mean preoperative far and near deviation was 94.10        19.33 @entity2 . The mean postoperative deviation was 14.60        18.07 @entity2 for far and 14.50        18.23 @entity2 for near deviation. In bilateral MRE cases, the mean dose-response effect of the elongation was 5.53        0.67 @entity2 /mm for far and 5.58        0.69 @entity2 /mm for near deviation. The mean LR muscle resection effect was 6.41        1.99 @entity2 /mm for far and 6.28        1.93 @entity2 /mm for near deviation. CONCLUSION: The MRE procedure seems an acceptable method to treat very large-angle @entity3 with surgery on a lower number of muscles.

title: Medial rectus muscle elongation, a technique to treat very large-angle XXXX .

answer: @entity3


abstract: UNASSIGNED: Coping with cold winter conditions is a major challenge for many insects. In early spring we observed newly emerged @entity0 subobscura, which had overwintered as larvae and pupae. As temperatures increase during spring these flies are faced with higher minimum and maximum temperatures in their natural microhabitat. Thus, there is a potential costly mismatch between winter and early spring acclimatization and the increased ambient temperatures later in adult life. We obtained individuals from a natural Danish population of D. subobscura and acclimated them in the laboratory to 20  C for one generation, and compared critical thermal maximum (CTmax) and minimum (CTmin) to that of individuals collected directly from their natural microhabitat. The two populations (laboratory and field) were subsequently both held in the laboratory at 20  C and tested for their CTmax and CTmin every third day for 28days. At the first day of testing, field acclimatized D. subobscura had both higher heat and cold resistance compared to laboratory flies, and thereby a considerable larger thermal scope. Following transfer to the laboratory, cold and heat resistance of the field flies decreased over time relative to the laboratory flies. Despite the substantial decrease in thermal tolerances the thermal scope remained larger for field acclimatized individuals for the duration of the experiment. We conclude that flies acclimatized to their natural microhabitat had increased cold resistance, without a loss in @entity1 . Thus while a negative correlation between cold and @entity1 is typically observed in laboratory studies in @entity0 sp., this was not observed for field acclimatized D. subobscura in this study. We suggest that this is an adaptation to juvenile overwintering in temperate cold environments, where developmental (winter) temperatures can be much lower than temperatures experienced by reproducing adults after emergence (spring). The ability to gain cold tolerance through acclimatization without a parallel loss of @entity1 affects thermal scope and suggests that high and low thermal tolerance act through mechanisms with different dynamics and reversibility.

title: No trade-off between high and low temperature tolerance in a winter acclimatized Danish XXXX subobscura population.

answer: @entity0


abstract: UNASSIGNED: Therapy for @entity1 (CD) with @entity5 is limited by systemic side effects. A novel formulation of fixed-dose, delayed-release @entity2 (DR-6MP) was developed, with local effect on the gut immune system and minimal absorption. The aim of this study was to evaluate the safety and efficacy of DR- @entity3 in @entity0 with moderately severe CD compared to systemically delivered @entity2 ( @entity2 ). Seventy CD @entity0 were enrolled into a 12-week, double-blind controlled trial. The primary end-point was the percentage of subjects with clinical remission [Crohn's Disease Activity Index (CDAI)  <  150] or clinical response (100-point CDAI reduction). Twenty-six (56  5%) and 13 (54  2%) subjects from the DR- @entity3 and @entity2 cohorts, respectively, completed the study. DR- @entity3 had similar efficacy to @entity2 following 12 weeks of treatment. However, the time to maximal clinical response was 8 weeks for DR- @entity3 versus 12 weeks for @entity2 . A higher proportion of @entity0 on DR- @entity3 showed clinical remission at week 8. A greater improvement in Inflammatory Bowel Disease Questionnaire (IBDQ) score was noted in the DR- @entity3 group. DR- @entity3 led to a decrease of @entity4 (+) expression on T cells, implying a reduction of lymphocyte adhesion to site of inflammation. DR- @entity3 was safer than @entity2 , with significantly fewer adverse events (AEs). There was no evidence of drug-induced leucopenia in the DR- @entity3 group; the proportion of subjects who developed hepatotoxicity was lower for the DR- @entity3 . Non-absorbable DR- @entity3 is safe and biologically active in the gut. It is clinically effective, exerting a systemic immune response with low systemic bioavailability and a low incidence of side effects.

title: Oral administration of non-absorbable delayed release @entity2 is locally active in the gut, exerts a systemic immune effect and alleviates XXXX with low rate of side effects: results of double blind Phase II clinical trial.

answer: @entity1


abstract: UNASSIGNED: Therapy for @entity1 (CD) with @entity5 is limited by systemic side effects. A novel formulation of fixed-dose, delayed-release @entity2 (DR-6MP) was developed, with local effect on the gut immune system and minimal absorption. The aim of this study was to evaluate the safety and efficacy of DR- @entity3 in @entity0 with moderately severe CD compared to systemically delivered @entity2 ( @entity2 ). Seventy CD @entity0 were enrolled into a 12-week, double-blind controlled trial. The primary end-point was the percentage of subjects with clinical remission [Crohn's Disease Activity Index (CDAI)  <  150] or clinical response (100-point CDAI reduction). Twenty-six (56  5%) and 13 (54  2%) subjects from the DR- @entity3 and @entity2 cohorts, respectively, completed the study. DR- @entity3 had similar efficacy to @entity2 following 12 weeks of treatment. However, the time to maximal clinical response was 8 weeks for DR- @entity3 versus 12 weeks for @entity2 . A higher proportion of @entity0 on DR- @entity3 showed clinical remission at week 8. A greater improvement in Inflammatory Bowel Disease Questionnaire (IBDQ) score was noted in the DR- @entity3 group. DR- @entity3 led to a decrease of @entity4 (+) expression on T cells, implying a reduction of lymphocyte adhesion to site of inflammation. DR- @entity3 was safer than @entity2 , with significantly fewer adverse events (AEs). There was no evidence of drug-induced leucopenia in the DR- @entity3 group; the proportion of subjects who developed hepatotoxicity was lower for the DR- @entity3 . Non-absorbable DR- @entity3 is safe and biologically active in the gut. It is clinically effective, exerting a systemic immune response with low systemic bioavailability and a low incidence of side effects.

title: Oral administration of non-absorbable delayed release XXXX is locally active in the gut, exerts a systemic immune effect and alleviates @entity1 with low rate of side effects: results of double blind Phase II clinical trial.

answer: @entity2


abstract: OBJECTIVE: To describe 2 cases of @entity9 ( @entity9 ) following the administration of @entity6 -adjuvanted @entity4 vaccine. CASE SUMMARY: An 83-year-old white @entity0 developed persistent @entity3 , @entity8 , and @entity10 about 2 days after receiving @entity4 vaccine. Clinical signs and laboratory evaluations suggested @entity9 . The @entity0 was treated with high-dose corticosteroids and immunoglobulins, and her clinical condition improved. A 74-year-old white @entity0 developed severe @entity2 and @entity7 3 days after the administration of @entity4 vaccine. Clinical signs and laboratory evaluations disclosed @entity9 . She was treated with @entity1 , rehydration, and blood transfusion; however, she died about 48 hours after hospitalization. DISCUSSION: @entity9 has been rarely described following @entity4 vaccine administration. In the cases described here, the causal relationship between @entity4 vaccination and the occurrence of @entity9 , assessed by means of World Health Organization criteria, was scored as probable. It has been proposed that the mechanism whereby vaccines induce @entity5 can be molecular mimicry, although a possible role of other vaccine constituents, with particular regard for adjuvants, such as @entity6 , can not be excluded. @entity11 , a constituent of @entity6 , has been suggested as a causative agent of autoimmune reactions. However, it is not clear how and under what conditions squalene can cause immune responses. CONCLUSIONS: Influenza vaccination may rarely trigger severe @entity9 , shortly after vaccine administration. A mechanism of molecular mimicry is probably involved in the development of these reactions, although the possible role of adjuvants can not be excluded. @entity0 should be instructed to report signs and symptoms of @entity5 occurring in the first weeks after administration of @entity4 vaccine.

title: Autoimmune hemolytic anemia following XXXX -adjuvanted @entity4 vaccine administration: a report of two cases.

answer: @entity6


abstract: OBJECTIVE: To describe 2 cases of @entity9 ( @entity9 ) following the administration of @entity6 -adjuvanted @entity4 vaccine. CASE SUMMARY: An 83-year-old white @entity0 developed persistent @entity3 , @entity8 , and @entity10 about 2 days after receiving @entity4 vaccine. Clinical signs and laboratory evaluations suggested @entity9 . The @entity0 was treated with high-dose corticosteroids and immunoglobulins, and her clinical condition improved. A 74-year-old white @entity0 developed severe @entity2 and @entity7 3 days after the administration of @entity4 vaccine. Clinical signs and laboratory evaluations disclosed @entity9 . She was treated with @entity1 , rehydration, and blood transfusion; however, she died about 48 hours after hospitalization. DISCUSSION: @entity9 has been rarely described following @entity4 vaccine administration. In the cases described here, the causal relationship between @entity4 vaccination and the occurrence of @entity9 , assessed by means of World Health Organization criteria, was scored as probable. It has been proposed that the mechanism whereby vaccines induce @entity5 can be molecular mimicry, although a possible role of other vaccine constituents, with particular regard for adjuvants, such as @entity6 , can not be excluded. @entity11 , a constituent of @entity6 , has been suggested as a causative agent of autoimmune reactions. However, it is not clear how and under what conditions squalene can cause immune responses. CONCLUSIONS: Influenza vaccination may rarely trigger severe @entity9 , shortly after vaccine administration. A mechanism of molecular mimicry is probably involved in the development of these reactions, although the possible role of adjuvants can not be excluded. @entity0 should be instructed to report signs and symptoms of @entity5 occurring in the first weeks after administration of @entity4 vaccine.

title: Autoimmune hemolytic anemia following @entity6 -adjuvanted XXXX vaccine administration: a report of two cases.

answer: @entity4


abstract: Whole oilseeds such as soya beans have been utilized in dairy rations to supply additional fat and protein. However, antinutritional components contained in soya beans, such as trypsin inhibitors and haemagglutinins (lectins) may alter digestibility of nutrients and consequently affect animal performance. The objective of the present experiment was to quantify the effect of different levels of whole raw soya beans in diets of dairy @entity1 on nutrient intake, total tract digestion, nutrient balances and milk yield and composition. Sixteen mid to late-lactation @entity1 (228    20 days in milk; mean    SD) were used in four replicated 4 * 4 Latin square design experiment with 21-d periods. @entity1 were assigned to each square according to milk yield and DIM. The animals were randomly allocated to treatments: control (without soya beans addition; CO), WS9, WS18 and WS27, with addition of 9%, 18% and 27% of whole raw soya bean in diet on a @entity0 ( @entity0 ) basis respectively. All diets contained identical forage and concentrate components and consisted of @entity5 silage and concentrate based on ground @entity6 and soya beans at a ratio of 60:40. There were no differences in OM, CP, NDF and NEL intakes (kg/day and MJ/day) among the treatments (p > 0.05). However, @entity0 and NFC intakes were negatively affected (p = 0.04 and p < 0.01, respectively) and ether extract (EE) intake was positively affected (p < 0.01). Total tract digestion increased linearly with whole raw soya beans for EE (p < 0.01) and NDF (p = 0.01). The excretion (kg/day) of digested soya beans grains increased linearly according to addition of whole raw soya beans. However, the nutritive characteristics of excreted grains were not altered. Milk (kg), milk @entity3 (kg) and protein (kg) yield decreased linearly (p < 0.01, p < 0.01 and p = 0.04, respectively) milk fat content (%) increased linearly (p < 0.01) with whole raw soya beans inclusion. Increasing addition of whole raw soya beans affected milk @entity2 profile with a linear decrease of cis-9-trans 11CLA and total saturated FA; and linear increase of total unsaturated and @entity7 FA. Energy balance was positively affected (p = 0.03) by whole raw soya beans as well as efficiency of NEL milk/DE intake (p = 0.02). @entity4 balance and microbial protein synthesis were not affected by whole raw soya beans. Increasing doses of whole raw soya beans decreased @entity0 intake and milk yield, however, led to an increase of unsaturated acids in milk and higher milk fat concentration.

title: Total tract nutrient digestion and milk XXXX profile of dairy @entity1 fed diets containing different levels of whole raw soya beans.

answer: @entity2


abstract: Whole oilseeds such as soya beans have been utilized in dairy rations to supply additional fat and protein. However, antinutritional components contained in soya beans, such as trypsin inhibitors and haemagglutinins (lectins) may alter digestibility of nutrients and consequently affect animal performance. The objective of the present experiment was to quantify the effect of different levels of whole raw soya beans in diets of dairy @entity1 on nutrient intake, total tract digestion, nutrient balances and milk yield and composition. Sixteen mid to late-lactation @entity1 (228    20 days in milk; mean    SD) were used in four replicated 4 * 4 Latin square design experiment with 21-d periods. @entity1 were assigned to each square according to milk yield and DIM. The animals were randomly allocated to treatments: control (without soya beans addition; CO), WS9, WS18 and WS27, with addition of 9%, 18% and 27% of whole raw soya bean in diet on a @entity0 ( @entity0 ) basis respectively. All diets contained identical forage and concentrate components and consisted of @entity5 silage and concentrate based on ground @entity6 and soya beans at a ratio of 60:40. There were no differences in OM, CP, NDF and NEL intakes (kg/day and MJ/day) among the treatments (p > 0.05). However, @entity0 and NFC intakes were negatively affected (p = 0.04 and p < 0.01, respectively) and ether extract (EE) intake was positively affected (p < 0.01). Total tract digestion increased linearly with whole raw soya beans for EE (p < 0.01) and NDF (p = 0.01). The excretion (kg/day) of digested soya beans grains increased linearly according to addition of whole raw soya beans. However, the nutritive characteristics of excreted grains were not altered. Milk (kg), milk @entity3 (kg) and protein (kg) yield decreased linearly (p < 0.01, p < 0.01 and p = 0.04, respectively) milk fat content (%) increased linearly (p < 0.01) with whole raw soya beans inclusion. Increasing addition of whole raw soya beans affected milk @entity2 profile with a linear decrease of cis-9-trans 11CLA and total saturated FA; and linear increase of total unsaturated and @entity7 FA. Energy balance was positively affected (p = 0.03) by whole raw soya beans as well as efficiency of NEL milk/DE intake (p = 0.02). @entity4 balance and microbial protein synthesis were not affected by whole raw soya beans. Increasing doses of whole raw soya beans decreased @entity0 intake and milk yield, however, led to an increase of unsaturated acids in milk and higher milk fat concentration.

title: Total tract nutrient digestion and milk @entity2 profile of dairy XXXX fed diets containing different levels of whole raw soya beans.

answer: @entity1


abstract: UNASSIGNED: @entity5 ( @entity5 ) is a heritable disorder of connective tissue caused by pathological variants in the @entity3 gene, which encodes the a1 chain of type III collagen. Type III collagen is a major component of skin, arterial walls, and the gastrointestinal tract. @entity2 manifests as an increased risk of @entity1 , perforation, and dissection of these structures. The most disruptive gene variants affect the collagen helix via glycine substitutions or splice donor site mutations. The C-propeptide region of @entity3 includes exons 49-52 and has a crucial role in initiating the C-terminal assembly of procollagen monomers in the early stages of collagen biosynthesis. Nineteen @entity3 variants have previously been reported in these exons, of which four were associated with a severe @entity5 phenotype. We identified two novel C-propeptide missense variants; @entity9 , @entity10 , and a non-stop mutation, @entity11 , p. (*1467Leuext*45). These variants produce variable phenotypes ranging from obvious acrogeria to classical or hypermobile @entity8 . A previously reported variant @entity12 is of unknown clinical significance but likely benign, based on this study. Assigning disease pathogenicity remains complex, clinical phenotyping and crystal structure evidence being crucial. We briefly compare reported phenotypes for @entity0 with missense variants in the C-propeptide domain for other @entity0 collagen disorders including @entity7 and @entity4 ( @entity6 ).    2015 Wiley Periodicals, Inc.

title: Clinical, structural, biochemical and X-ray crystallographic correlates of pathogenicity for variants in the C-propeptide region of the XXXX gene.

answer: @entity3


abstract: INTRODUCTION: @entity1 ( @entity1 ) are a major cause of @entity4 , orthopnea, and @entity5 . The aim of the study was to obtain diagnostic findings, assess therapeutic options, and review outcomes in @entity6 @entity0 . METHODS: From 2004 to 2013, @entity0 with @entity6 referred to the author's institution were studied using clinical, pulmonary function, and electrodiagnostic tests. A PubMed search of published @entity6 reports was also done. @entity6 ( @entity6 ) and @entity6 ( @entity6 ) @entity0 were compared. RESULTS: The analysis consisted of 10 @entity6 and 9 @entity6 @entity0 seen by the author, plus previous reports of 18 @entity6 and 40 @entity6 @entity0 . @entity6 @entity0 were older (in the author's series) and were more often @entity2 . They reported @entity3 less often, @entity4 and orthopnea more often, and had worse results on pulmonary function tests than @entity6 @entity0 . CONCLUSIONS: @entity6 and @entity6 are probably 2 variants of the same, immune-mediated focal @entity1 . Electrodiagnosis is a valuable confirmatory test for @entity6 . Muscle Nerve, 2015.

title: XXXX : A case series and review of the literature.

answer: @entity1


abstract: PURPOSE: The @entity1 assessment test (CAT) is a questionnaire that assesses the impact of @entity1 ( @entity1 ) on health status, but some @entity0 have difficulties filling it up by themselves. We examined whether the mode of administration of the Spanish version of CAT (self vs. interviewer) influences its scores and/or psychometric properties. METHODS: Observational, prospective study in 49 Spanish centers that includes clinically stable @entity1 @entity0 (n  =  153) and @entity0 hospitalized because of an exacerbation (ECOPD; n  =  224). The CAT was self-administered (CAT-SA) or administered by an interviewer (CAT-IA) based on the investigator judgment of the @entity0 's capacity. To assess convergent validity, the Saint George's @entity2 Questionnaire (SGRQ) and the London Chest Activity of Daily Living (LCADL) instrument were also administered. Psychometric properties were compared across modes of administration. RESULTS: A total of 118 @entity0 (31  %) completed the CAT-SA and 259 (69  %) CAT-IA. Multiple regression analysis showed that mode of administration did not affect CAT scores. The CAT showed excellent psychometric properties in both modes of administration. Internal consistency coefficients (Cronbach's alpha) were high (0.86 for CAT-SA and 0.85 for CAT-IA) as was test-retest reliability (intraclass correlation coefficients of 0.83 for CAT-SA and CAT-IA). Correlations with SGRQ and LCADL were moderate to strong both in CAT-SA and CAT-IA, indicating good convergent validity. Similar results were observed when testing longitudinal validity. CONCLUSIONS: The mode of administration does not influence CAT scores or its psychometric properties. Hence, both modes of administration can be used in clinical practice depending on the physician judgment of @entity0 's capacity.

title: Does the XXXX assessment test (CAT(TM)) questionnaire produce similar results when self- or interviewer administered?

answer: @entity1