abstract: OBJECTIVE: To observe the expression of p- @entity4 mitogen-activated protein kinase in lung tissues of @entity2 @entity1 model induced by lipopolysaccharide (LPS) and to explore the protective effects of @entity3 (MT) in lung tissues in @entity1 . METHODS: Seventy-two @entity1 was randomly assigned to three groups, control group, LPS group and LPS + MT group. @entity1 model of ALI was established by instilling LPS intratracheally. We used immunohistochemical SP and Western blot method to detect the expression of p- @entity4 mitogen-activated protein kinase in lung tissues and used light microscope to observe morphological changes. RESULTS: There were rare p- @entity4 mitogen-activated protein kinase positive cells scattered in alveolar and airway epithelial cells in control group (P < 0.01). The positive p- @entity4 mitogen-activated protein kinase cells in LPS group increased obviously than those in control group (P < 0.01), and were mainly distributed in infiltrative inflammatory cells, airway epithelial cells, alveolar epithelial cells and pleurames epithelial cells. In MT group, the p- @entity4 mitogen-activated protein kinase positive cells in airway and lung tissues were much less than those in the LPS group (P < 0.05). The Western blot results were consistent with those of immunohistochemical method. CONCLUSION: The expression of p- @entity4 mitogen-activated protein kinase increases in alveolar and airway epithelial cells in @entity2 @entity1 models induced by LPS. The activation of p- @entity4 mitogen-activated protein kinase is found in most lung tissues, suggesting that p- @entity4 mitogen-activated protein kinase participates in the signal transduction in inflammatory and noninflammatory cells. MT is an effective antioxidant, which relieves the @entity0 in @entity2 @entity1 , possibly through the inhibition of the pathway of @entity4 MAPK over activation.

title: [Protective effects of @entity3 in XXXX @entity1 caused by LPS].

answer: @entity2


abstract: OBJECTIVE: To observe the expression of p- @entity4 mitogen-activated protein kinase in lung tissues of @entity2 @entity1 model induced by lipopolysaccharide (LPS) and to explore the protective effects of @entity3 (MT) in lung tissues in @entity1 . METHODS: Seventy-two @entity1 was randomly assigned to three groups, control group, LPS group and LPS + MT group. @entity1 model of ALI was established by instilling LPS intratracheally. We used immunohistochemical SP and Western blot method to detect the expression of p- @entity4 mitogen-activated protein kinase in lung tissues and used light microscope to observe morphological changes. RESULTS: There were rare p- @entity4 mitogen-activated protein kinase positive cells scattered in alveolar and airway epithelial cells in control group (P < 0.01). The positive p- @entity4 mitogen-activated protein kinase cells in LPS group increased obviously than those in control group (P < 0.01), and were mainly distributed in infiltrative inflammatory cells, airway epithelial cells, alveolar epithelial cells and pleurames epithelial cells. In MT group, the p- @entity4 mitogen-activated protein kinase positive cells in airway and lung tissues were much less than those in the LPS group (P < 0.05). The Western blot results were consistent with those of immunohistochemical method. CONCLUSION: The expression of p- @entity4 mitogen-activated protein kinase increases in alveolar and airway epithelial cells in @entity2 @entity1 models induced by LPS. The activation of p- @entity4 mitogen-activated protein kinase is found in most lung tissues, suggesting that p- @entity4 mitogen-activated protein kinase participates in the signal transduction in inflammatory and noninflammatory cells. MT is an effective antioxidant, which relieves the @entity0 in @entity2 @entity1 , possibly through the inhibition of the pathway of @entity4 MAPK over activation.

title: [Protective effects of @entity3 in @entity2 XXXX caused by LPS].

answer: @entity1


abstract: OBJECTIVE: To evaluate whether the pulsatile component of blood pressure can be a risk factor independent of the steady component in elderly females. DESIGN: Fifty-two elderly @entity2 female @entity0 were compared with 32 normotensive control subjects of the same age. According to the results of that first study, a cohort of 126 elderly females was studied over a 3-year period to evaluate whether the pulsatile and steady-state components of blood pressure correlated with the same parameters and could predict the occurrence of @entity1 . RESULTS: In the first study the @entity2 @entity0 with elevated pulse pressure had significantly higher @entity4 level and lower urinary @entity3 excretion than the @entity2 @entity0 with lower pulse pressure and than the control subjects of the same age. The incidence of @entity1 over a 3-year period was significantly higher in the elderly @entity2 females with increased pulse pressure. In the cohort of 126 females mean arterial pressure (MAP) and pulse pressure did not show the same degree of correlation with the biological parameters tested (plasma @entity4 : MAP r = 0.162, P < 0.05; pulse pressure r = 0.314, P < 0.0005; urinary @entity3 excretion: MAP r = -0.365, P < 0.0001; pulse pressure r = -0.257, P < 0.002). Furthermore, for the same MAP level, @entity0 with @entity1 in a 3-year period had significantly higher pulse pressure values. Pulse pressure (and not MAP) was a strong predictor of @entity1 . CONCLUSIONS: In elderly @entity2 females the pulsatile and the steady-state components of blood pressure did not correlate with the same biological parameters. Furthermore, the pulsatile component, when explored by pulse pressure, seemed to be a strong independent @entity1 factor.

title: Pulsatile versus steady-state component of blood pressure in elderly females: an independent risk factor for XXXX ?

answer: @entity1


abstract: The rapid onset of normal maternal behaviour after parturition in @entity0 , consisting of cleaning, warming, feeding and protection of offspring, is primed by @entity3 , @entity2 and @entity1 . Previous studies showed that passive transfer of monoclonal antibodies against @entity2 significantly increases the incidence of maternal rejection of pups. To test the hypothesis that aberrant maternal behaviour is due to partial @entity2 withdrawal leading to hormonal imbalance during late pregnancy, maternal rejection was assessed following treatment with a @entity2 receptor antagonist. @entity4 ( @entity4 ) was given subcutaneously on either day 2 (100 micrograms) or day 17 (50 micrograms) of pregnancy, or on the first day of lactation (100 micrograms). Maternal behaviour was monitored twice daily for the first 6 days of lactation and pup rejection recorded for a further 15 days. Maternal rejection was significantly greater after @entity4 administration on either day 2 or day 17 (28.6% and 38.3%) compared with controls (11.1% and 5.2% respectively). Rejection was negligible in both treated and control groups if @entity4 was given after parturition. When mothers were treated at day 17, the length of the latent period before pups were retrieved and returned to the nest was markedly increased in @entity4 -treated mothers (46.3 s) compared with controls (4.4 s) though the effect was transient. The results indicate that @entity4 interferes with the hormonal priming mechanism(s) necessary for the onset of normal maternal behaviour by a receptor-mediated effect. The similarity of the present results and those obtained with anti- @entity2 antibodies implies that receptor antagonism or antibody scavenging of @entity2 influence a common central nervous mechanism that is essential for the normal priming process.

title: Aberrant maternal behaviour in @entity0 treated with a XXXX receptor antagonist during pregnancy.

answer: @entity2


abstract: The rapid onset of normal maternal behaviour after parturition in @entity0 , consisting of cleaning, warming, feeding and protection of offspring, is primed by @entity3 , @entity2 and @entity1 . Previous studies showed that passive transfer of monoclonal antibodies against @entity2 significantly increases the incidence of maternal rejection of pups. To test the hypothesis that aberrant maternal behaviour is due to partial @entity2 withdrawal leading to hormonal imbalance during late pregnancy, maternal rejection was assessed following treatment with a @entity2 receptor antagonist. @entity4 ( @entity4 ) was given subcutaneously on either day 2 (100 micrograms) or day 17 (50 micrograms) of pregnancy, or on the first day of lactation (100 micrograms). Maternal behaviour was monitored twice daily for the first 6 days of lactation and pup rejection recorded for a further 15 days. Maternal rejection was significantly greater after @entity4 administration on either day 2 or day 17 (28.6% and 38.3%) compared with controls (11.1% and 5.2% respectively). Rejection was negligible in both treated and control groups if @entity4 was given after parturition. When mothers were treated at day 17, the length of the latent period before pups were retrieved and returned to the nest was markedly increased in @entity4 -treated mothers (46.3 s) compared with controls (4.4 s) though the effect was transient. The results indicate that @entity4 interferes with the hormonal priming mechanism(s) necessary for the onset of normal maternal behaviour by a receptor-mediated effect. The similarity of the present results and those obtained with anti- @entity2 antibodies implies that receptor antagonism or antibody scavenging of @entity2 influence a common central nervous mechanism that is essential for the normal priming process.

title: Aberrant maternal behaviour in XXXX treated with a @entity2 receptor antagonist during pregnancy.

answer: @entity0


abstract: BACKGROUND: Bronchiectasis is defined as an abnormal and irreversible dilation and distortion of the bronchi, which has numerous causes. Surgical treatment of this disease is usually reserved for focal disease and when the medical treatment is no longer effective. We report our center experience and outcomes in @entity2 surgery during the last 20 years. METHODS: Between 1994 and 2014, sixty-nine @entity0 underwent surgical resection for @entity2 . @entity0 demographics, presenting symptoms, indications for surgical treatment, type of lung resection, morbidity and mortality, as well as clinical follow-up and outcomes were analyzed. RESULTS: From the 69 @entity0 included, 31 (44.9%) were male and 38 (55.1%) were female. Surgery was indicated because of unsuccessful medical therapy in 33 @entity0 (47.8%), haemoptysis in 22 @entity0 (31.9%), nondiagnostic lung mass in 9 @entity0 (13.0%) and @entity1 in 5 @entity0 (7.3%). The surgical procedures were lobectomy in 45 (65.2%) @entity0 , pneumonectomy in 10 (14.5%) @entity0 , bilobectomy in 8 (11.6%) @entity0 , lobectomy plus segmentectomy in 3 (4.3%) @entity0 and only segmentectomy in 3 (4.3%) @entity0 . Morbidity rate was 14.5% and there was no perioperative mortality. The follow-up was possible in 60 @entity0 , with an outcome reported as excellent in 44 (73.3%) @entity0 , as improved in 11 (18.3%) and as unchanged in 5 (8.3%). CONCLUSION: Although the number of @entity0 with @entity2 referred for surgical treatment has decreased, pulmonary resection still plays a significant role. Surgical resection of localized @entity2 is a safe procedure with proven improvement of quality of life for the majority of @entity0 .

title: Surgical treatment of XXXX : A review of 20 years of experience.

answer: @entity2


abstract: To estimate the effect of cell proliferation and deletion on the growth of the @entity0 @entity3 and eight @entity4 were examined. Tubular @entity3 were categorized into three grades of cellular atypia: mild, moderate, and severe. @entity4 were given a single grade. Morphological characteristics of apoptosis (nuclear condensation and budding) were used to quantify an apoptotic index, AI (percentage of apoptotic cells in viable adenomatous cells). The apoptotic cells were found mainly among the basal site of the adenomatous tubules. The AIs of tubular @entity3 with mild, moderate, and severe grades of atypia were 3.5, 5.7 and 8.8 per cent, respectively. The AI of @entity4 was 1.8 per cent, which was significantly lower than that of tubular @entity3 . The mitotic indices, MIs (percentage of mitotic cells in viable adenomatous cells) of tubular @entity3 were 0.41 per cent (mild), 0.58 per cent (moderate), and 0.83 per cent (severe), and for @entity4 the MI was 0.38 per cent. There was a close positive relationship between the AI and @entity3 , which paralleled the grade of atypia. These results indicate that both cell proliferation and @entity2 were more frequent in @entity3 with severe atypia than in @entity3 with mild atypia. Moreover, the significantly lower AI of @entity4 , known to develop into large @entity1 when compared with tubular @entity3 , suggests that reduced apoptoses may lead to a shift in tissue kinetics towards expansive growth.

title: Role of apoptosis in modulation of the growth of XXXX colorectal tubular and villous adenomas.

answer: @entity0


abstract: BACKGROUND: The diagnosis of @entity3 ( @entity3 ) is often delayed in @entity0 with @entity2 2 @entity1 . Serum total @entity4 levels are inversely associated with @entity3 . However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic @entity1 @entity0 at higher risk for having obstructive @entity3 . METHODS: We performed a cross-sectional study of 460 consecutive asymptomatic @entity0 with @entity2 2 @entity1 . All @entity0 underwent coronary computed tomographic angiography, and their serum total @entity4 levels were measured. Obstructive @entity3 was defined as >= 50% diameter stenosis in at least one coronary artery. RESULTS: Serum total @entity4 tertiles showed an inverse association with the prevalence of obstructive @entity3 . In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total @entity4 was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1   mol/L in serum total @entity4 level was associated with a 14.6% decrease in obstructive @entity3 after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total @entity4 level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028). CONCLUSION: Serum total @entity4 level is inversely associated with obstructive @entity3 and provides additive risk information over the FRS. Serum total @entity4 may be helpful for identifying asymptomatic @entity0 with @entity2 2 @entity1 who are at higher risk for obstructive @entity3 .

title: Serum Total XXXX Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic @entity1 @entity0 at Higher Risk for Coronary Artery Stenosis.

answer: @entity4


abstract: BACKGROUND: The diagnosis of @entity3 ( @entity3 ) is often delayed in @entity0 with @entity2 2 @entity1 . Serum total @entity4 levels are inversely associated with @entity3 . However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic @entity1 @entity0 at higher risk for having obstructive @entity3 . METHODS: We performed a cross-sectional study of 460 consecutive asymptomatic @entity0 with @entity2 2 @entity1 . All @entity0 underwent coronary computed tomographic angiography, and their serum total @entity4 levels were measured. Obstructive @entity3 was defined as >= 50% diameter stenosis in at least one coronary artery. RESULTS: Serum total @entity4 tertiles showed an inverse association with the prevalence of obstructive @entity3 . In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total @entity4 was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1   mol/L in serum total @entity4 level was associated with a 14.6% decrease in obstructive @entity3 after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total @entity4 level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028). CONCLUSION: Serum total @entity4 level is inversely associated with obstructive @entity3 and provides additive risk information over the FRS. Serum total @entity4 may be helpful for identifying asymptomatic @entity0 with @entity2 2 @entity1 who are at higher risk for obstructive @entity3 .

title: Serum Total @entity4 Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic XXXX @entity0 at Higher Risk for Coronary Artery Stenosis.

answer: @entity1


abstract: BACKGROUND: The diagnosis of @entity3 ( @entity3 ) is often delayed in @entity0 with @entity2 2 @entity1 . Serum total @entity4 levels are inversely associated with @entity3 . However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic @entity1 @entity0 at higher risk for having obstructive @entity3 . METHODS: We performed a cross-sectional study of 460 consecutive asymptomatic @entity0 with @entity2 2 @entity1 . All @entity0 underwent coronary computed tomographic angiography, and their serum total @entity4 levels were measured. Obstructive @entity3 was defined as >= 50% diameter stenosis in at least one coronary artery. RESULTS: Serum total @entity4 tertiles showed an inverse association with the prevalence of obstructive @entity3 . In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total @entity4 was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1   mol/L in serum total @entity4 level was associated with a 14.6% decrease in obstructive @entity3 after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total @entity4 level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028). CONCLUSION: Serum total @entity4 level is inversely associated with obstructive @entity3 and provides additive risk information over the FRS. Serum total @entity4 may be helpful for identifying asymptomatic @entity0 with @entity2 2 @entity1 who are at higher risk for obstructive @entity3 .

title: Serum Total @entity4 Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic @entity1 XXXX at Higher Risk for Coronary Artery Stenosis.

answer: @entity0


abstract: During 2 years and 8 months (1980.9.-1983.4), 100 @entity0 of @entity6 were admitted to our hospital. Of these @entity0 , 43 who had clinical symptoms of @entity7 , RIND, or bruits on the neck or supraclavicular fossa, were reviewed. Ages ranged from 46 to 81 years (mean: 66.3). Male to female ratio was 1.9:1. Of the 43 @entity0 , 33 were submitted to arteriography of the branches of the aortic arch. Thirty-two but one had @entity3 on the 62 arteries: 32 carotid, 18 vertebral, and 12 subclavian arteries, respectively. Morphologically there were 42 stenoses, 13 occlusions, 7 aneurysmal dilatations, and three other lesions. Seven @entity0 were involved only one artery and 25 were involved more than two arteries. Eight @entity0 were involved other regions such as lower extremities, too. Of the 43 @entity0 , 12 were operated upon and there were no operative @entity4 and complications. Three of 31 who were treated conservatively, died of @entity1 and @entity5 . Although operative indications for @entity7 or RIND have been defined, those for asymptomatic lesions have not been established. Once @entity2 occurred, however, it would become difficult to recover from it. It is hoped that operative indications for asymptomatic lesions are established as soon as possible.

title: [ XXXX of the aortic arch branches. An analysis of 43 cases].

answer: @entity6


abstract: @entity2 cells, clone PC12, possess neuronal nicotinic @entity0 ( @entity1 ) receptors which can be activated by an agonist to produce a transient transmembrane cation flux similar to that seen with neuromuscular nicotinic ACh receptors. We have observed that these neuronal nicotinic ACh receptors are subject to long term regulation by the cholinergic agonist @entity3 ( @entity3 ). Receptor function was measured by agonist-induced uptake of 86Rb+ into the cells. Chronic exposure to concentrations of @entity3 that caused receptor activation induced an adaptation (down-regulation) of the receptors, seen as a decrease in the responsiveness of the cells to a subsequent exposure to @entity3 . The extent of the decreased responsiveness was proportional to the concentration of @entity3 between 50 microM and 10 mM and was distinct from acute receptor desensitization. The concentrations of @entity3 that caused down-regulation were greater than those that caused maximum receptor activation, but were similar to those that greatly enhanced desensitization. This suggested that promotion of the desensitized state of the receptor could be the true stimulus for down-regulation. Adaptation was observed initially after several hours of exposure and maximally within about 7 days. Recovery from the down-regulated state required several days of growth in the absence of @entity3 . Treatment with the antagonist @entity4 did not cause a similar change in the responsiveness of the cells. However, concurrent exposure to @entity3 and @entity4 prevented down-regulation. Therefore, it appeared that receptor activation was necessary for regulation to occur. Comparison of the cellular responses of chronically treated and control cells to acute stimulation with @entity3 supported the hypothesis that the mechanism for this down-regulation in PC12 cells was a decrease in the number of functional ACh receptors.

title: Agonist-induced regulation of the neuronal nicotinic XXXX receptor of PC12 cells.

answer: @entity0


abstract: OBJECTIVES: Research has suggested that @entity0 suffering from @entity2 ( @entity2 ) experience deficits in the related domains of social cognition and metacognition. Most research has focused on detecting deficits among @entity0 who are acutely symptomatic. Thus, little is known about whether these deficits persist after symptoms have remitted. As a first, this study investigated social @entity1 in @entity0 with @entity2 in the acute and remitted state. DESIGN: Longitudinal case-control. METHODS: Forty-four drug-na  ve @entity2 @entity0 and an equal number of matched healthy controls were assessed in multiple domains of social cognition including theory of mind, social perception, and metacognition. Additionally, a comprehensive neurocognitive (non-social) test battery was utilized. Following baseline assessment, @entity0 were enrolled in an outpatient treatment programme. @entity0 reaching remission within 6  months (n  =  29) were reassessed 6  months post-remission. Included for analysis were only @entity0 who followed a course of remission (n  =  29) and their paired healthy controls (n  =  29). RESULTS: Analyses of variance revealed that remitted @entity0 performed significantly better at retest than at baseline on nearly all measures. These effects withstood adjusting for test-retest effects. Moreover, remitted @entity0 performed up to level of healthy controls on some but not all social cognitive tasks and metacognition at retest. CONCLUSIONS: Overall, results suggests that social cognitive and metacognitive ability may improve with symptom remission in major @entity2 although it may not reach a level equal to @entity0 who have never experienced @entity2 . PRACTITIONER POINTS: Many with @entity2 experience @entity1 . When @entity2 remits, social cognition may improve. After remission, first-episode @entity2 @entity0 may still experience @entity1 . We have yet to determine whether social @entity1 existed prior to the onset of @entity2 . Longer-term longitudinal studies of social cognition in @entity2 are needed. Treatment was pharmacological and non-manualized psychotherapy, the effects of which were not controlled for. Sample sizes were modest, which must caution against generalization of the results.

title: The course of social cognitive and metacognitive ability in XXXX : Deficit are only partially normalized after full remission of first episode major @entity2 .

answer: @entity2


abstract: OBJECTIVES: Research has suggested that @entity0 suffering from @entity2 ( @entity2 ) experience deficits in the related domains of social cognition and metacognition. Most research has focused on detecting deficits among @entity0 who are acutely symptomatic. Thus, little is known about whether these deficits persist after symptoms have remitted. As a first, this study investigated social @entity1 in @entity0 with @entity2 in the acute and remitted state. DESIGN: Longitudinal case-control. METHODS: Forty-four drug-na  ve @entity2 @entity0 and an equal number of matched healthy controls were assessed in multiple domains of social cognition including theory of mind, social perception, and metacognition. Additionally, a comprehensive neurocognitive (non-social) test battery was utilized. Following baseline assessment, @entity0 were enrolled in an outpatient treatment programme. @entity0 reaching remission within 6  months (n  =  29) were reassessed 6  months post-remission. Included for analysis were only @entity0 who followed a course of remission (n  =  29) and their paired healthy controls (n  =  29). RESULTS: Analyses of variance revealed that remitted @entity0 performed significantly better at retest than at baseline on nearly all measures. These effects withstood adjusting for test-retest effects. Moreover, remitted @entity0 performed up to level of healthy controls on some but not all social cognitive tasks and metacognition at retest. CONCLUSIONS: Overall, results suggests that social cognitive and metacognitive ability may improve with symptom remission in major @entity2 although it may not reach a level equal to @entity0 who have never experienced @entity2 . PRACTITIONER POINTS: Many with @entity2 experience @entity1 . When @entity2 remits, social cognition may improve. After remission, first-episode @entity2 @entity0 may still experience @entity1 . We have yet to determine whether social @entity1 existed prior to the onset of @entity2 . Longer-term longitudinal studies of social cognition in @entity2 are needed. Treatment was pharmacological and non-manualized psychotherapy, the effects of which were not controlled for. Sample sizes were modest, which must caution against generalization of the results.

title: The course of social cognitive and metacognitive ability in @entity2 : Deficit are only partially normalized after full remission of first episode major XXXX .

answer: @entity2


abstract: UNASSIGNED: The use of biomaterials has been demonstrated as a viable strategy to promote cell survival and cardiac repair. However, limitations on combinational cell-biomaterial therapies exist, as cellular behavior is influenced by the microenvironment and physical characteristics of the material. Among the different scaffolds employed for cardiac tissue engineering, a myocardial derived matrix has been shown to promote cardiogenesis in @entity1 cardiac progenitor cells (mCPCs) in vitro. In this study, we investigated the influence of the myocardial matrix hydrogel on @entity9 -like @entity0 fetal and adult CPCs (fCPCs and aCPCs) when encapsulated in 3D in vitro. fCPCs encapsulated in the myocardial matrix showed an increase in the gene expression level of cardiac markers @entity6 and @entity7 and the vascular marker @entity2 after 4 days in culture, and a significant increase in @entity6 up to 1 week. Increased gene expression levels of @entity8 , @entity5 , @entity2 and @entity3 were also observed when aCPCs were cultured in the matrix compared to collagen. Cell survival was sustained in both hydrogels up to 1 week in culture with the myocardial matrix capable of enhancing the expression of the proliferation marker Ki-67 after 4 days in culture. When encapsulated CPCs were treated with @entity4 , an improved survival of the cells cultured in the myocardial matrix was observed. Finally, we evaluated the use of the myocardial matrix as hydrogel for in vivo cell transplantation and demonstrated that the gelation properties of the hydrogel are not influenced by the cells. In summary, we showed that the myocardial matrix hydrogel promotes @entity0 CPCs cardiogenic potential, proliferation and survival and is a favorable hydrogel for 3D in vitro culture. Furthermore, we demonstrated the in vivo applicability of the matrix as a potential vehicle for cell transplantation.

title: Cardiac derived extracellular matrix enhances cardiogenic properties of XXXX cardiac progenitor cells.

answer: @entity0


abstract: UNASSIGNED: BACKGROUND In contrast to the well-described beneficial organic effects of liver transplantation (OLT) in @entity0 with @entity3 , changes in the mental status of @entity0 after OLT remain poorly understood. The current study seeks to evaluate the influence of OLT on @entity1 , @entity2 , and dispositional optimism in @entity0 with @entity3 . MATERIAL AND METHODS Questionnaires were sent to @entity0 on the OLT waiting list and @entity0 after OLT. @entity2 / @entity1 and dispositional optimism were assessed using the HADS and LOT-R questionnaires, respectively. These findings were compared to results from the general population. RESULTS The number of returned questionnaires was 292 of 940 (31.1%; 57 @entity0 on the liver transplant waiting list: waiting group, 235 liver transplant recipients: OLT group). Both @entity2 and @entity1 scores were significantly higher in the waiting group when compared to the OLT group (p<0.05) and the general population ( @entity1 : p<0.001, @entity2 : p<0.05), respectively. The OLT group was characterized by significantly higher @entity1 scores (p<0.001) compared to the general population. @entity2 and summation scores did not differ (p>0.05). Dispositional optimism was higher in the OLT group compared to the waiting group (p<0.05) and to the general population (p<0.01). The waiting group had equal values as the general population (p>0.05). CONCLUSIONS Besides beneficial effects on liver function, OLT appears to be associated with significant improvements in @entity2 and @entity1 and a more optimistic view of life.

title: Mental Status in XXXX Before and After Liver Transplantation.

answer: @entity0


abstract: The synthetic hexapeptide @entity3 -releasing peptide ( @entity5 -6) stimulates @entity3 ( @entity3 ) release in animals and @entity0 . @entity4 ( @entity4 ) has the same effect. In addition, pulsatile administration of @entity4 in normal @entity0 results in @entity1 ( @entity1 ) and blunted @entity2 levels. The effect of @entity5 on nocturnal hormone secretion and on the sleep electroencephalogram (EEG) is still unknown. We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of @entity5 and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of @entity3 , ACTH and @entity2 (20.00 to 07.00 h) in normal male controls. After @entity5 , the @entity3 concentration (22.00 to 03.00 h) increased (15.4 +/- 9.6 ng/ml after @entity5 vs. 5.5 +/- 4.0 ng/ml after PL, p < 0.02), as did the ACTH level (22.00 to 02.00 h: 21.0 +/- 5.3 pg/ml after @entity5 vs. 16.6 +/- 3.1 pg/ml after PL, p < 0.02). During the total night, and particularly during the first half of the night, @entity2 secretion was enhanced (22.00 to 03.00 h: 56.0 +/- 31.0 ng/ml after @entity5 vs. 25.2 +/- 9.0 ng/ml after PL, p < 0.02). Stage 2 sleep increased (270.1 +/- 25.3 min after @entity5 vs. 245.4 +/- 25.8 min after PL, p < 0.02), whereas other sleep-EEG variables including @entity1 remained unchanged. Our data demonstrate that @entity5 stimulates not only @entity3 release but also hypothalamic-pituitary-adrenocortical hormone secretion. The latter effect is opposite to the blunting of @entity2 after @entity4 . Both @entity5 and @entity4 promote sleep. However, @entity5 enhances stage 2 sleep and does not affect @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity3 -releasing peptide-6 stimulates sleep, XXXX , ACTH and @entity2 release in normal @entity0 .

answer: @entity3


abstract: The synthetic hexapeptide @entity3 -releasing peptide ( @entity5 -6) stimulates @entity3 ( @entity3 ) release in animals and @entity0 . @entity4 ( @entity4 ) has the same effect. In addition, pulsatile administration of @entity4 in normal @entity0 results in @entity1 ( @entity1 ) and blunted @entity2 levels. The effect of @entity5 on nocturnal hormone secretion and on the sleep electroencephalogram (EEG) is still unknown. We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of @entity5 and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of @entity3 , ACTH and @entity2 (20.00 to 07.00 h) in normal male controls. After @entity5 , the @entity3 concentration (22.00 to 03.00 h) increased (15.4 +/- 9.6 ng/ml after @entity5 vs. 5.5 +/- 4.0 ng/ml after PL, p < 0.02), as did the ACTH level (22.00 to 02.00 h: 21.0 +/- 5.3 pg/ml after @entity5 vs. 16.6 +/- 3.1 pg/ml after PL, p < 0.02). During the total night, and particularly during the first half of the night, @entity2 secretion was enhanced (22.00 to 03.00 h: 56.0 +/- 31.0 ng/ml after @entity5 vs. 25.2 +/- 9.0 ng/ml after PL, p < 0.02). Stage 2 sleep increased (270.1 +/- 25.3 min after @entity5 vs. 245.4 +/- 25.8 min after PL, p < 0.02), whereas other sleep-EEG variables including @entity1 remained unchanged. Our data demonstrate that @entity5 stimulates not only @entity3 release but also hypothalamic-pituitary-adrenocortical hormone secretion. The latter effect is opposite to the blunting of @entity2 after @entity4 . Both @entity5 and @entity4 promote sleep. However, @entity5 enhances stage 2 sleep and does not affect @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX -releasing peptide-6 stimulates sleep, @entity3 , ACTH and @entity2 release in normal @entity0 .

answer: @entity3


abstract: The synthetic hexapeptide @entity3 -releasing peptide ( @entity5 -6) stimulates @entity3 ( @entity3 ) release in animals and @entity0 . @entity4 ( @entity4 ) has the same effect. In addition, pulsatile administration of @entity4 in normal @entity0 results in @entity1 ( @entity1 ) and blunted @entity2 levels. The effect of @entity5 on nocturnal hormone secretion and on the sleep electroencephalogram (EEG) is still unknown. We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of @entity5 and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of @entity3 , ACTH and @entity2 (20.00 to 07.00 h) in normal male controls. After @entity5 , the @entity3 concentration (22.00 to 03.00 h) increased (15.4 +/- 9.6 ng/ml after @entity5 vs. 5.5 +/- 4.0 ng/ml after PL, p < 0.02), as did the ACTH level (22.00 to 02.00 h: 21.0 +/- 5.3 pg/ml after @entity5 vs. 16.6 +/- 3.1 pg/ml after PL, p < 0.02). During the total night, and particularly during the first half of the night, @entity2 secretion was enhanced (22.00 to 03.00 h: 56.0 +/- 31.0 ng/ml after @entity5 vs. 25.2 +/- 9.0 ng/ml after PL, p < 0.02). Stage 2 sleep increased (270.1 +/- 25.3 min after @entity5 vs. 245.4 +/- 25.8 min after PL, p < 0.02), whereas other sleep-EEG variables including @entity1 remained unchanged. Our data demonstrate that @entity5 stimulates not only @entity3 release but also hypothalamic-pituitary-adrenocortical hormone secretion. The latter effect is opposite to the blunting of @entity2 after @entity4 . Both @entity5 and @entity4 promote sleep. However, @entity5 enhances stage 2 sleep and does not affect @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity3 -releasing peptide-6 stimulates sleep, @entity3 , ACTH and XXXX release in normal @entity0 .

answer: @entity2


abstract: The synthetic hexapeptide @entity3 -releasing peptide ( @entity5 -6) stimulates @entity3 ( @entity3 ) release in animals and @entity0 . @entity4 ( @entity4 ) has the same effect. In addition, pulsatile administration of @entity4 in normal @entity0 results in @entity1 ( @entity1 ) and blunted @entity2 levels. The effect of @entity5 on nocturnal hormone secretion and on the sleep electroencephalogram (EEG) is still unknown. We compared the effect of repetitive i.v. boluses (4 x 50 micrograms) of @entity5 and placebo (PL) on the sleep EEG (23.00 to 07.00 h) and on the secretion profiles of @entity3 , ACTH and @entity2 (20.00 to 07.00 h) in normal male controls. After @entity5 , the @entity3 concentration (22.00 to 03.00 h) increased (15.4 +/- 9.6 ng/ml after @entity5 vs. 5.5 +/- 4.0 ng/ml after PL, p < 0.02), as did the ACTH level (22.00 to 02.00 h: 21.0 +/- 5.3 pg/ml after @entity5 vs. 16.6 +/- 3.1 pg/ml after PL, p < 0.02). During the total night, and particularly during the first half of the night, @entity2 secretion was enhanced (22.00 to 03.00 h: 56.0 +/- 31.0 ng/ml after @entity5 vs. 25.2 +/- 9.0 ng/ml after PL, p < 0.02). Stage 2 sleep increased (270.1 +/- 25.3 min after @entity5 vs. 245.4 +/- 25.8 min after PL, p < 0.02), whereas other sleep-EEG variables including @entity1 remained unchanged. Our data demonstrate that @entity5 stimulates not only @entity3 release but also hypothalamic-pituitary-adrenocortical hormone secretion. The latter effect is opposite to the blunting of @entity2 after @entity4 . Both @entity5 and @entity4 promote sleep. However, @entity5 enhances stage 2 sleep and does not affect @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity3 -releasing peptide-6 stimulates sleep, @entity3 , ACTH and @entity2 release in normal XXXX .

answer: @entity0


abstract: OBJECTIVE: The authors review the physiologic basis, indications, techniques, and results of the planned reoperation approach to severe @entity1 . SUMMARY BACKGROUND DATA: Multivisceral @entity1 and exsanguinating @entity3 lead to @entity6 , @entity4 , and @entity2 . Formal resections and reconstructions in these unstable @entity0 often result in irreversible physiologic insult. A new surgical strategy addresses these physiologic concerns by staged control and repair of the injuries. METHOD: The authors review the literature. RESULTS: Indications for planned reoperation include avoidance of irreversible physiologic insult and inability to obtain direct hemostasis or formal abdominal closure. The three phases of the strategy include initial control, stabilization, and delayed reconstruction. Various techniques are used to obtain rapid temporary control of @entity3 and hollow @entity8 . @entity6 , @entity4 , and the @entity7 are major postoperative concerns. Definitive repair of the injuries is undertaken after stabilization. CONCLUSION: Planned reoperation offers a simple and effective alternative to the traditional surgical management of complex or @entity5 in critically wounded @entity0 .

title: Planned reoperation for severe XXXX .

answer: @entity1


abstract: Six different agglutinating antisera were obtained by immunizing @entity1 with @entity3 -treated strains of @entity4 . After appropriate absorption, these antisera were used to define six serogroups designated by the letters A, B, C, D, F, and G. Altogether, 315 strains of @entity4 from various origins were tested for slide agglutination by these antisera; 312 (99%) of them were agglutinated by one of these antisera. A and C were the most common serogroups. An excellent correlation, ranging from 85 to 100%, was found between the serogroup and the toxigenicity of the strains. The correlation between serogroup and @entity5 fermentation was higher, ranging from 89 to 100%. The results of this typing were compared with the clinical origin of the strains. Only strains of serogroups A, C, and D were isolated in 153 cases of antibiotic-associated @entity2 . This series included strains from three outbreaks; all the strains in two of the outbreaks belonged to serogroup C, and in the third, all the strains belonged to serogroup A. Strains of serogroups B, F, and G were only found in the stools of asymptomatic neonates or young @entity0 . In the latter samples, strains of serogroups A and D were found in the same ratio as in adults with antibiotic-associated @entity2 , but strains of serogroup C were seldom isolated. In @entity0 treated with antineoplastic drugs and suffering from @entity2 , the distribution of the strains was the same as in cases of antibiotic-associated @entity2 .

title: Serogrouping of XXXX strains by slide agglutination.

answer: @entity4


abstract: More than 300 sera from @entity0 with a connective tissue disease were analyzed with the immunoblotting technique. The presence of autoantibodies against an 86,000-mol wt marker antigen for @entity4 (Scl-86) was found in 14 out of 33 @entity0 with @entity2 . The presence of anti-Scl-86 antibodies seemed to correlate with the diagnosis of @entity4 since they were found in 13 out of 22 @entity4 @entity0 and in only one out of 11 @entity0 with @entity5 . All @entity2 sera (33 @entity0 ' sera and 13 reference sera) were also tested for the presence of anti-Scl-70 antibodies. It was found that all anti-Scl-70 positive sera (n = 25) contained anti-Scl-86 antibody as well, suggesting a relationship between these two antigens. However, the Scl-86 antigen was shown to be an extremely insoluble nonchromosomal protein, resistant to boiling in @entity3 . This contrasts with the Scl-70 antigen, which has been described as a thermolabile, soluble antigen present in the chromatin fraction. Together, our results are consistent with the idea that Scl-70 is a degradation product of Scl-86. The Scl-86 antigen is present in freshly prepared @entity1 thymus, spleen, and liver nuclei as well as in nuclei from various cultured cell lines, but is not detectable in extractable nuclear antigen from @entity1 thymus. In a limited retrospective study, the anti-Scl-86 antibodies were found in two sera from @entity0 with Raynaud's phenomenon before the development of @entity4 . Therefore, it is possible that screening of patients' serum for this antibody might predict the development of @entity4 .

title: Scl-86, a marker antigen for XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate whether high @entity2 intake is an independent risk factor for @entity4 in middle-aged @entity0 and whether it confers a poor prognosis. METHODS: A two-phase study was performed. Risk factors for @entity4 were evaluated in a case-control study of 50 @entity0 and 50 controls. Prognostic factors and microbiologic and clinical features were then evaluated in a cohort study of the 50 middle-aged @entity0 with @entity4 . RESULTS: In the first study, the only independent risk factor for @entity4 was high @entity2 intake (P < .02). In the second study, @entity0 with @entity9 had a higher incidence of @entity1 caused by gram-negative bacilli (P < .03), as well as a higher incidence of @entity8 (P < .03), @entity5 (P < .0001), and gram-negative bacilli (P < .001) in the cultures of pharyngeal smears than did the nonalcoholics. Compared with nonalcoholic @entity0 , @entity6 @entity0 with @entity1 showed more severe clinical symptoms (P < .02), required longer intravenous treatment (P < .02) and longer hospital stay (P < .01), and had multilobar involvement and @entity7 (both P < .01), as well as slower resolution of @entity3 . The only prognostic factor for mortality was high @entity2 intake (P < .03). CONCLUSIONS: High @entity2 intake is the main risk factor for developing @entity4 in middle-aged @entity0 . This situation also confers a worse prognosis in these @entity0 , who should be treated with broad-spectrum antibiotics for a longer period.

title: High @entity2 intake as a risk and prognostic factor for XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate whether high @entity2 intake is an independent risk factor for @entity4 in middle-aged @entity0 and whether it confers a poor prognosis. METHODS: A two-phase study was performed. Risk factors for @entity4 were evaluated in a case-control study of 50 @entity0 and 50 controls. Prognostic factors and microbiologic and clinical features were then evaluated in a cohort study of the 50 middle-aged @entity0 with @entity4 . RESULTS: In the first study, the only independent risk factor for @entity4 was high @entity2 intake (P < .02). In the second study, @entity0 with @entity9 had a higher incidence of @entity1 caused by gram-negative bacilli (P < .03), as well as a higher incidence of @entity8 (P < .03), @entity5 (P < .0001), and gram-negative bacilli (P < .001) in the cultures of pharyngeal smears than did the nonalcoholics. Compared with nonalcoholic @entity0 , @entity6 @entity0 with @entity1 showed more severe clinical symptoms (P < .02), required longer intravenous treatment (P < .02) and longer hospital stay (P < .01), and had multilobar involvement and @entity7 (both P < .01), as well as slower resolution of @entity3 . The only prognostic factor for mortality was high @entity2 intake (P < .03). CONCLUSIONS: High @entity2 intake is the main risk factor for developing @entity4 in middle-aged @entity0 . This situation also confers a worse prognosis in these @entity0 , who should be treated with broad-spectrum antibiotics for a longer period.

title: High XXXX intake as a risk and prognostic factor for @entity4 .

answer: @entity2


abstract: OBJECTIVE: To investigate the expression profile of serum micro (mi)RNAs in @entity3 ( @entity6 ) and investigate the regulatory contribution of miRNAs to the invasive and @entity1 . METHODS: Microarray analysis was carried out using serum samples collected from 30 @entity0 with @entity6 , @entity5 tissues and the corresponding normal tissues collected from 10 patients, and serum samples from 50 healthy volunteers. The miRNAs identified as dysregulated in @entity6 were verified by RT-PCR. Focused analysis on @entity7 was carried out using the @entity0 @entity6 cell lines HCCC-9810 and RBE to investigate the role of this miRNA in @entity4 expression (using @entity4 induction), cell growth, invasiveness and @entity1 (using @entity7 mimic transfection). The one-way ANOVA test was used for statistical analysis. RESULTS: Forty-three miRNAs were dysregulated in @entity6 (vs. @entity6 , P<0.01), of which 22 were upregulated and 21 were downregulated. RT-PCR data showed that the @entity7 was significantly upregulated in serum as well as in @entity2 tissue from @entity6 @entity0 . Induction of HCCC-9810 and RBE cells with @entity4 showed a time-dependent upregulation of @entity7 . Furthermore, the HCCC-9810 and RBE cells transfected with @entity7 mimic showed enhanced cell growth, invasiveness and migratory ability. CONCLUSION: @entity4 may promote the invasive and metastatic properties of @entity6 through upregulated @entity7 . Studies of the differentially expressed serum miRNAs in @entity6 may help to further elucidate the pathogenic processes of this disease and aid in the development of a novel and effective therapeutic strategy.

title: [Regulatory role of serum @entity7 in invasiveness and @entity1 of XXXX ].

answer: @entity3


abstract: OBJECTIVE: To investigate the expression profile of serum micro (mi)RNAs in @entity3 ( @entity6 ) and investigate the regulatory contribution of miRNAs to the invasive and @entity1 . METHODS: Microarray analysis was carried out using serum samples collected from 30 @entity0 with @entity6 , @entity5 tissues and the corresponding normal tissues collected from 10 patients, and serum samples from 50 healthy volunteers. The miRNAs identified as dysregulated in @entity6 were verified by RT-PCR. Focused analysis on @entity7 was carried out using the @entity0 @entity6 cell lines HCCC-9810 and RBE to investigate the role of this miRNA in @entity4 expression (using @entity4 induction), cell growth, invasiveness and @entity1 (using @entity7 mimic transfection). The one-way ANOVA test was used for statistical analysis. RESULTS: Forty-three miRNAs were dysregulated in @entity6 (vs. @entity6 , P<0.01), of which 22 were upregulated and 21 were downregulated. RT-PCR data showed that the @entity7 was significantly upregulated in serum as well as in @entity2 tissue from @entity6 @entity0 . Induction of HCCC-9810 and RBE cells with @entity4 showed a time-dependent upregulation of @entity7 . Furthermore, the HCCC-9810 and RBE cells transfected with @entity7 mimic showed enhanced cell growth, invasiveness and migratory ability. CONCLUSION: @entity4 may promote the invasive and metastatic properties of @entity6 through upregulated @entity7 . Studies of the differentially expressed serum miRNAs in @entity6 may help to further elucidate the pathogenic processes of this disease and aid in the development of a novel and effective therapeutic strategy.

title: [Regulatory role of serum @entity7 in invasiveness and XXXX of @entity3 ].

answer: @entity1


abstract: OBJECTIVE: To investigate the expression profile of serum micro (mi)RNAs in @entity3 ( @entity6 ) and investigate the regulatory contribution of miRNAs to the invasive and @entity1 . METHODS: Microarray analysis was carried out using serum samples collected from 30 @entity0 with @entity6 , @entity5 tissues and the corresponding normal tissues collected from 10 patients, and serum samples from 50 healthy volunteers. The miRNAs identified as dysregulated in @entity6 were verified by RT-PCR. Focused analysis on @entity7 was carried out using the @entity0 @entity6 cell lines HCCC-9810 and RBE to investigate the role of this miRNA in @entity4 expression (using @entity4 induction), cell growth, invasiveness and @entity1 (using @entity7 mimic transfection). The one-way ANOVA test was used for statistical analysis. RESULTS: Forty-three miRNAs were dysregulated in @entity6 (vs. @entity6 , P<0.01), of which 22 were upregulated and 21 were downregulated. RT-PCR data showed that the @entity7 was significantly upregulated in serum as well as in @entity2 tissue from @entity6 @entity0 . Induction of HCCC-9810 and RBE cells with @entity4 showed a time-dependent upregulation of @entity7 . Furthermore, the HCCC-9810 and RBE cells transfected with @entity7 mimic showed enhanced cell growth, invasiveness and migratory ability. CONCLUSION: @entity4 may promote the invasive and metastatic properties of @entity6 through upregulated @entity7 . Studies of the differentially expressed serum miRNAs in @entity6 may help to further elucidate the pathogenic processes of this disease and aid in the development of a novel and effective therapeutic strategy.

title: [Regulatory role of serum XXXX in invasiveness and @entity1 of @entity3 ].

answer: @entity7


abstract: @entity5 ( @entity5 ) accounts for 56% of @entity7 in @entity0 and adolescents. @entity0 with @entity3 rarely develop @entity1 ; however, @entity4 occurs in approximately 50% of @entity0 and leads to a 5-year survival rate of only 10-20%. Therefore, identifying the genes and pathways involved in @entity1 , as new therapeutic targets, is crucial to improve long-term survival of @entity5 @entity0 . Novel markers that define metastatic @entity5 were identified using comparative transcriptomic analyses of two highly metastatic ( @entity10 ) and two poorly metastatic clonal variants (C4 and C5) isolated from the metastatic @entity5 cell line, KHOS. Using this approach, we determined that the metastatic phenotype correlated with overexpression of @entity8 ( @entity8 ) or @entity2 ( @entity2 ). Validation in @entity0 biopsies confirmed @entity8 and @entity2 targets were highly expressed in 29-42% of metastatic @entity5 @entity0 biopsies, with no detectable expression in non-malignant bone or samples from @entity5 @entity0 with @entity3 . @entity6 (AF) was used to selectively target and inhibit @entity9 ( @entity9 ). At low doses, AF was able to inhibit @entity9 activity without a significant effect on cell viability whereas at higher doses, AF could induce ROS-dependent apoptosis. AF treatment, in vivo, significantly reduced the development of @entity4 and we provide evidence that this effect may be due to an AF-dependent increase in cellular ROS. Thus, @entity8 may represent a novel druggable target that could be deployed to reduce the development of fatal @entity4 in @entity0 with @entity5 .

title: @entity6 is a potent suppressor of osteosarcoma XXXX .

answer: @entity1


abstract: @entity5 ( @entity5 ) accounts for 56% of @entity7 in @entity0 and adolescents. @entity0 with @entity3 rarely develop @entity1 ; however, @entity4 occurs in approximately 50% of @entity0 and leads to a 5-year survival rate of only 10-20%. Therefore, identifying the genes and pathways involved in @entity1 , as new therapeutic targets, is crucial to improve long-term survival of @entity5 @entity0 . Novel markers that define metastatic @entity5 were identified using comparative transcriptomic analyses of two highly metastatic ( @entity10 ) and two poorly metastatic clonal variants (C4 and C5) isolated from the metastatic @entity5 cell line, KHOS. Using this approach, we determined that the metastatic phenotype correlated with overexpression of @entity8 ( @entity8 ) or @entity2 ( @entity2 ). Validation in @entity0 biopsies confirmed @entity8 and @entity2 targets were highly expressed in 29-42% of metastatic @entity5 @entity0 biopsies, with no detectable expression in non-malignant bone or samples from @entity5 @entity0 with @entity3 . @entity6 (AF) was used to selectively target and inhibit @entity9 ( @entity9 ). At low doses, AF was able to inhibit @entity9 activity without a significant effect on cell viability whereas at higher doses, AF could induce ROS-dependent apoptosis. AF treatment, in vivo, significantly reduced the development of @entity4 and we provide evidence that this effect may be due to an AF-dependent increase in cellular ROS. Thus, @entity8 may represent a novel druggable target that could be deployed to reduce the development of fatal @entity4 in @entity0 with @entity5 .

title: XXXX is a potent suppressor of osteosarcoma @entity1 .

answer: @entity6


abstract: PURPOSE: To see whether increasing the dose of hyperfractionated radiation therapy from 72 to 78 Gy would increase survival time in @entity0 with @entity2 , particularly those with brain stem or @entity1 . METHODS: Seventy-eight @entity0 with a clinical and radiographic diagnosis of a brain stem or thalamic @entity2 were enrolled in a trial to receive 78 Gy (1.0 Gy twice a day). Six @entity0 with disease in other sites were also treated. The initial response to therapy was determined by comparing pretreatment magnetic resonance images and neurological examinations with those obtained within 2 weeks of completing therapy; subsequent responses were determined from bimonthly follow-up images. Time-to- @entity1 progression was measured from the date radiation therapy began until the date of documented radiographic or clinical progression. Survival time was measured from the date radiation therapy began until the date of @entity3 . Cox proportional hazards analysis was used to estimate the effects of specific variables on survival. RESULTS: Of 81 evaluable @entity0 , 68 received > or = 76 Gy, 10 received between 70 and 75 Gy, and 3 received between 60 and 68 Gy. The overall response or stabilization rate was 70.4%. @entity1 size decreased in 30.8% of @entity0 ; 39.5% had stable disease, and 29.6% had immediate progression. The median survival time was 12.7 months (16.1 months for adults and 10.8 months for @entity0 ). The median time to @entity1 progression was 9.0 months (11.4 months for adults and 8.4 months for @entity0 ). A duration of symptoms < or = 2 months and a diffuse lesion were each associated with shorter survival and progression times. CONCLUSIONS: For @entity0 with brain stem or @entity4 , increasing the dose of radiation therapy from 72 to 78 Gy did not significantly improve survival. Different treatment strategies are clearly needed.

title: The treatment of brain stem and XXXX with 78 Gy of hyperfractionated radiation therapy.

answer: @entity4


abstract: BACKGROUND: The risk for @entity5 and the prognostic significance of pedunculated-type T1 @entity2 ( @entity3 ) require further study. We aimed to assess the validity of the 2014 Japanese Society for @entity4 (JSCCR) guidelines based on long-term outcomes of pedunculated-type T1 @entity3 . METHODS: In this multicenter retrospective cohort study, we examined 176 @entity0 who underwent resection endoscopically or surgically at 14 institutions between January 1990 and December 2010. @entity0 meeting the JSCCR curative criteria were defined as "endoscopically curable (e-curable)" and those who did not were "non-e-curable". We evaluated the prognosis of 116 @entity0 (58 e-curable, 58 non-e-curable) who were observed for  >5  years after treatment. RESULTS: Overall incidence of @entity5 was 5  % (4/81; 95  % confidence interval 1.4-12  %: three cases of submucosal invasion depth  >= 1000   m [stalk invasion] and lymphatic invasion, one case of head invasion and budding grade 2/3). There was no local or metastatic recurrence in the e-curable @entity0 , but six of them died of another cause (observation period, 80  months). There was no local recurrence in the non-e-curable @entity0 ; however, distant @entity1 was observed in one @entity0 . Death due to the primary disease was not observed in non-e-curable @entity0 , but six of them died of another cause (observation period, 72  months). CONCLUSIONS: Our data support the validity of the JSCCR curative criteria for pedunculated-type T1 @entity3 . Endoscopic resection cannot be considered curative for pedunculated-type T1 CRC with head invasion alone.

title: Long-term outcomes after treatment for pedunculated-type T1 XXXX : a multicenter retrospective cohort study.

answer: @entity2


abstract: We describe three cases of a fibroinflammatory @entity5 (tumefactive fibroinflammatory lesion) of the middle and inner ear. The @entity0 presented with @entity4 in the affected ear and no response to caloric stimulation. The computed tomographic pattern showed destruction of inner ear structures and a typical widening of parts of the labyrinth. Magnetic resonance imaging performed in all three @entity0 showed an extension greater than expected based on computed tomographic images of both areas of destruction, as well as areas of radiologic normality. An enhancing mass was seen in the inner ear with a characteristic extension into both the internal auditory canal and the middle ear. A transotic approach or subtotal petrosectomy was used to remove the @entity1 in all three cases. Although histologically benign, these @entity1 are locally destructive and, as such, behave like a @entity3 . They are composed of fibrovascular tissue admixed with chronic inflammatory cells. To our knowledge, this is the first report on @entity5 of the middle ear, inner ear, and internal auditory canal. @entity5 used to be a somewhat confusing term for a recognized entity of unknown origin. It is likely that @entity2 is an important contributing factor in the development of these lesions. Although surgical removal seems to be the treatment of choice, no clear judgment of its prognosis can be made owing to the rarity of this @entity1 .

title: XXXX of the ear. A locally destructive benign lesion.

answer: @entity5


abstract: BACKGROUND:    The use of mold-active @entity9 for antifungal prophylaxis after allogeneic @entity1 ( @entity1 ) is hindered by adverse events and drug-drug interactions. Higher doses of @entity8 administered intermittently may be an alternative in this setting. METHODS:    This was a single-center, observational 5-year study to characterize the safety and efficacy of intermittent administration of high-dose intravenous @entity5 (>= 5 doses of >= 300 mg @entity5 2-3 times weekly) in @entity0 with @entity7 and allogeneic @entity1 recipients. RESULTS:    A total of 104 @entity0 (84 allogeneic @entity1 recipients and 20 @entity0 with @entity6 ) received intermittent high-dose intravenous @entity5 , 83 (79.8%) as prophylaxis. Large variability in the @entity5 dosing regimen was observed; 78 (75%) @entity0 received >75% of their course as 300 mg @entity5 3 times weekly. Liver function tests decreased from baseline to end of treatment (EOT; P < .001). @entity0 with normal baseline liver function (n = 55 [52%]) maintained similar enzyme levels throughout the study. For @entity0 with abnormal baseline liver function (n = 49 [47%]), liver function tests significantly improved from baseline to EOT (P  <= .005). Duration and/or @entity5 dosing algorithms were not associated with liver @entity2 at EOT. There were no significant changes in renal function, and infusion-related reactions or deaths were not observed. Five of 83 (6.0%) @entity0 in the prophylaxis group developed a breakthrough @entity3 . CONCLUSIONS:    In this largest cohort of @entity0 to date, intermittent administration of high-dose @entity5 was well tolerated, without any associated @entity4 , and may be considered an alternative antifungal prophylactic strategy. Prospective studies are needed to further validate these findings.

title: Safety and Efficacy of Intermittent Intravenous Administration of High-Dose XXXX .

answer: @entity5


abstract: UNASSIGNED: Personalized medicine shows promise for maximizing efficacy and minimizing @entity3 of anti- @entity1 treatment. @entity5 exon 2 mutations are predictive of resistance to @entity4 -directed monoclonal antibodies in @entity0 with metastatic @entity2 . Recent studies have shown that broader RAS testing ( @entity5 and @entity6 ) is needed to select @entity0 for treatment. While Sanger sequencing is still used, approaches based on various methodologies are available. Few CE-approved kits, however, detect the full spectrum of RAS mutations. More recently, "next-generation" sequencing has been developed for research use, including parallel semiconductor sequencing and reversible termination. These techniques have high technical sensitivities for detecting mutations, although the ideal threshold is currently unknown. Finally, liquid biopsy has the potential to become an additional tool to assess @entity1 -derived DNA. For accurate and timely RAS testing, appropriate sampling and prompt delivery of material is critical. Processes to ensure efficient turnaround from sample request to RAS evaluation must be implemented so that @entity0 receive the most appropriate treatment. Given the variety of methodologies, external quality assurance programs are important to ensure a high standard of RAS testing. Here, we review technical and practical aspects of RAS testing for pathologists working with metastatic @entity2 samples. The extension of markers from @entity5 to RAS testing is the new paradigm for biomarker testing in @entity2 .

title: RAS testing in metastatic XXXX : advances in Europe.

answer: @entity2


abstract: BACKGROUND: Gonadal sex determination (GSD) in @entity0 is a complex biological process that takes place in early stages of embryonic development when the bipotential gonadal primordium (BGP) differentiates towards testes or ovaries. This decision is directed by one of two distinct pathways embedded in a GSD network activated in a population of coelomic epithelial cells, the Sertoli progenitor cells (SPC) and the granulosa progenitor cells (GPC). In males, the pathway is activated when the @entity3 ( @entity3 ) gene starts to be expressed, whereas in females the @entity4 / @entity1 pathway promotes the differentiation of the GPCs towards ovaries. The interactions and dynamics of the elements that constitute the GSD network are poorly understood, thus our group is interested in inferring the general architecture of this network as well as modeling the dynamic behavior of a set of genes associated to this process under wild-type and mutant conditions. METHODS: We reconstructed the regulatory network of GSD with a set of genes directly associated with the process of differentiation from SPC and GPC towards Sertoli and granulosa cells, respectively. These genes are experimentally well-characterized and the effects of their deficiency have been clinically reported. We modeled this GSD network as a synchronous Boolean network model (BNM) and characterized its attractors under wild-type and mutant conditions. RESULTS: Three attractors with a clear biological meaning were found; one of them corresponding to the currently known gene expression pattern of Sertoli cells, the second correlating to the granulosa cells and, the third resembling a disgenetic gonad. CONCLUSIONS: The BNM of GSD that we present summarizes the experimental data on the pathways for Sertoli and granulosa establishment and sheds light on the overall behavior of a population of cells that differentiate within the developing gonad. With this model we propose a set of regulatory interactions needed to activate either the @entity3 or the @entity4 / @entity1 pathway as well as their downstream targets, which are critical for further sex differentiation. In addition, we observed a pattern of altered regulatory interactions and their dynamics that lead to some @entity2 ( @entity2 ).

title: A Boolean network model of XXXX gonadal sex determination.

answer: @entity0


abstract: Thirty-seven diminutive flat depressed @entity3 of the colon, smaller than 5 mm, were detected by contrast chromoscopy using an indigo carmine capsule and subsequently removed by endoscopic mucosal resection. We investigated the endoscopic, macroscopic, and histologic characteristics of these lesions and also evaluated the usefulness of chromoscopy and the magnifying endoscope for detecting this type of lesion. The lesions were classified into two types according to the measured height of the histologic sections: 28 lesions were truly flat depressed and the remaining 9 lesions were flat elevated. Of the 37 lesions, 18 were @entity2 with mild atypia, 14 with moderate atypia, and 5 with severe atypia. The flat depressed lesions included 12 with mild atypia, 11 with moderate atypia, and 5 with severe atypia. No @entity1 was present in either type, and no @entity2 with severe atypia was identified in any of the flat elevated lesions. The overall rate of severe atypia was 13.5%; the rate of severe atypia for the flat depressed type was 17.9%, which is approximately 14-fold greater than that of ordinary diminutive polypoid @entity2 (1.3%). The detection of these lesions was facilitated by the use of indigo @entity4 dye, which clearly demonstrated the mucosal irregularities. The frequency of detection of these lesions was increased four to five times with a magnifying endoscope, as occurred in nearly 10% of all of the @entity0 examined. These data suggest that the finding of endoscopically minute flat depressed @entity3 is not at all uncommon when examination is meticulously performed.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Minute flat depressed XXXX of the colon detected by contrast chromoscopy using an indigo carmine capsule.

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to compare the three different treatment methods and investigate The effectiveness of the therapeutic effect of common salt. METHODS: This retrospective study involved @entity0 who were treated in our clinic for umbilical @entity2 between January 2010 and December 2011. The @entity0 were divided to three subgroups according to treatment methods. Group I: Cases treated with only local debridement and systemic antibiotic, group II: cases treated with local debridement, systemic antibiotic and @entity4 , group 3: cases treated with debridement, systemic antibiotic and salt. RESULTS: In this study, 63 @entity0 with the diagnosis of @entity3 were treated in our clinic. The @entity0 were classified into three groups; group I included 20 @entity0 , group II included 18 @entity0 and group III included 18 @entity0 . During 16-24 months of follow-up, 4 (20%) recurrences in group1 and 2 (11.1%) recurrences in group 2 were detected. Recurrence rate of group 3 was significantly different (5.55%) when compared to group 2. The mean period for returning to daily activities and work was 1 day for the @entity0 . CONCLUSION: In conclusion, we suggest that @entity2 cases which are not complicated by abcess and cellulitis can be treated by local removal of umbilical hairs, debridement and dressing without surgery. We conclude that application of common salt (table/ cooking salt) to umbilical @entity2 with @entity1 is a simple and highly effective way of treatment without any relapse and complications. KEY WORDS: Conservative treatment, Local debridement, Umblical @entity2 .

title: Effective conservative treatment of umbilical @entity2 : XXXX ? Salt?

answer: @entity4


abstract: OBJECTIVE: The aim of this study was to compare the three different treatment methods and investigate The effectiveness of the therapeutic effect of common salt. METHODS: This retrospective study involved @entity0 who were treated in our clinic for umbilical @entity2 between January 2010 and December 2011. The @entity0 were divided to three subgroups according to treatment methods. Group I: Cases treated with only local debridement and systemic antibiotic, group II: cases treated with local debridement, systemic antibiotic and @entity4 , group 3: cases treated with debridement, systemic antibiotic and salt. RESULTS: In this study, 63 @entity0 with the diagnosis of @entity3 were treated in our clinic. The @entity0 were classified into three groups; group I included 20 @entity0 , group II included 18 @entity0 and group III included 18 @entity0 . During 16-24 months of follow-up, 4 (20%) recurrences in group1 and 2 (11.1%) recurrences in group 2 were detected. Recurrence rate of group 3 was significantly different (5.55%) when compared to group 2. The mean period for returning to daily activities and work was 1 day for the @entity0 . CONCLUSION: In conclusion, we suggest that @entity2 cases which are not complicated by abcess and cellulitis can be treated by local removal of umbilical hairs, debridement and dressing without surgery. We conclude that application of common salt (table/ cooking salt) to umbilical @entity2 with @entity1 is a simple and highly effective way of treatment without any relapse and complications. KEY WORDS: Conservative treatment, Local debridement, Umblical @entity2 .

title: Effective conservative treatment of umbilical XXXX : @entity4 ? Salt?

answer: @entity2


abstract: BACKGROUND: The number of surgeries in older @entity0 with comorbidities is constantly growing. The present study examined the impact of @entity1 and long-term survival in @entity0 with completely resected @entity2 . METHODS: Between 2004 and 2008, 423 @entity0 with @entity2 underwent complete resection. A retrospective comparison of perioperative mortality, morbidity, Charlson comorbidity index (CCI), and postoperative length of hospital stay was performed. RESULTS: The number of @entity0 with CCI 0, 1-2, and >= 3 was 226, 170 and 27, respectively. The 5-year overall survival was 88% among @entity0 with CCI 0, and 84% in those with CCI >= 1 (p   =   0.05) in all pathological stages. The CCI 0 group had significantly better overall survival than CCI 0 group and 30 (15%) in the CCI >= 1 group (p   =   0.024). Length of stay was shorter in the CCI 0 group (11        5 days) than in the CCI >= 1 group (15        19 days, p   =   0.015). CONCLUSIONS: A high CCI correlated with higher postoperative morbidity and longer length of stay. We identified better a prognosis in @entity0 with CCI 0 compared to those with CCI 1-2.

title: Impact of comorbidity index on morbidity and survival in XXXX .

answer: @entity2


abstract: @entity5 deaminase (EC 4.3.1.8; @entity6 ) is the third enzyme of the @entity2 biosynthetic pathway. In both @entity0 and @entity1 , the gene encoding @entity6 possesses two promoters, lying in close proximity. We have previously reported the mapping of six nuclear @entity4 hypersensitive sites at the @entity6 locus which could contribute to the regulation of the gene. In the present study, and in order to define all the elements necessary for a high level of expression and an integration site independence, we studied the pattern and the level of expression of a cloned @entity6 gene following integration into a host genome. The longest construct that we tested (12.5 kilobases) contained sufficient regulatory elements to promote expression levels similar to that of the endogenous gene, both in @entity1 and in transfected cells. The overall contribution of individual @entity4 hypersensitive sites to the expression of the gene was then studied using a series of mutants that were stably transfected into @entity1 @entity3 cells. Two regions seem to play a critical role in the erythroid-specific expression of the @entity6 gene: the proximal promoter and a region situated at -1000 relative to the initiation site. Study of individual clones of @entity1 @entity3 cells revealed that the erythroid-specific expression of the gene was submitted to position effects in the absence of the upstream region, although the housekeeping transcription is not sensitive to such effects. The tandem arrangement of the housekeeping and tissue-specific promoters of the @entity6 gene raises some questions about the functioning of these two overlapping transcriptional units in erythroid cells. Previous data have suggested that in erythroid cells most of the transcripts initiated at the upstream promoter stop downstream of the first ubiquitous exon, between the two promoters. Here, we show that the deletion of a constitutive @entity4 hypersensitive site that is located in the region of the elongation block results in opposite effects on the steady state levels of housekeeping and tissue-specific RNA. This finding is consistent with the hypothesis that this region promotes premature termination of the housekeeping transcripts therefore preventing promoter interference.

title: Functional analysis of XXXX hypersensitive sites at the @entity1 porphobilinogen deaminase gene locus. Different requirements for position-independent expression from its two promoters.

answer: @entity4


abstract: @entity5 deaminase (EC 4.3.1.8; @entity6 ) is the third enzyme of the @entity2 biosynthetic pathway. In both @entity0 and @entity1 , the gene encoding @entity6 possesses two promoters, lying in close proximity. We have previously reported the mapping of six nuclear @entity4 hypersensitive sites at the @entity6 locus which could contribute to the regulation of the gene. In the present study, and in order to define all the elements necessary for a high level of expression and an integration site independence, we studied the pattern and the level of expression of a cloned @entity6 gene following integration into a host genome. The longest construct that we tested (12.5 kilobases) contained sufficient regulatory elements to promote expression levels similar to that of the endogenous gene, both in @entity1 and in transfected cells. The overall contribution of individual @entity4 hypersensitive sites to the expression of the gene was then studied using a series of mutants that were stably transfected into @entity1 @entity3 cells. Two regions seem to play a critical role in the erythroid-specific expression of the @entity6 gene: the proximal promoter and a region situated at -1000 relative to the initiation site. Study of individual clones of @entity1 @entity3 cells revealed that the erythroid-specific expression of the gene was submitted to position effects in the absence of the upstream region, although the housekeeping transcription is not sensitive to such effects. The tandem arrangement of the housekeeping and tissue-specific promoters of the @entity6 gene raises some questions about the functioning of these two overlapping transcriptional units in erythroid cells. Previous data have suggested that in erythroid cells most of the transcripts initiated at the upstream promoter stop downstream of the first ubiquitous exon, between the two promoters. Here, we show that the deletion of a constitutive @entity4 hypersensitive site that is located in the region of the elongation block results in opposite effects on the steady state levels of housekeeping and tissue-specific RNA. This finding is consistent with the hypothesis that this region promotes premature termination of the housekeeping transcripts therefore preventing promoter interference.

title: Functional analysis of @entity4 hypersensitive sites at the XXXX porphobilinogen deaminase gene locus. Different requirements for position-independent expression from its two promoters.

answer: @entity1


abstract: In an attempt to relate the translational characteristics of @entity1 (A1MV) RNAs to their structure [Ravelonandro et al. (1983) Nucleic Acids Res. 11, 2815-2826; Gehrke et al. (1983) Biochemistry 22, 5157-5164] we measured the relative affinities (discrimination ratios) of these RNAs for the initiation complex, in the @entity0 germ extract and in the nuclease-treated reticulocyte lysate, using a competition method designed by Brendler et al. [(1981) J. Biol. Chem. 256, 11747-11754]. As a prerequisite of this study we ascertained that the molecular mass distribution of the translation products was independent of RNA concentration in both translation systems. In the @entity0 germ extract the discrimination ratios are very similar for two strains of A1MV (S and B) which differ mainly by the presence (strain S) or absence (strain B) of a stable 5'-proximal hairpin. Hence this structure has no bearing on discrimination. Taking the affinity of RNA 3 as reference, the following orders of magnitude are found for the affinities of the different RNAs in the @entity0 germ: RNA 3, 1.0; RNA 1, 10; RNA 2, 60; RNA 4, 150. In the reticulocyte lysate the discrimination ratios are not significantly different from the @entity0 germ. Thus it seems that the mechanism of discrimination is essentially the same in the two translation systems, despite a difference in rate-limitation.

title: Translational discrimination between the four RNAs of XXXX . A quantitative evaluation.

answer: @entity1


abstract: From 1981 to 1983, we implanted Bioceram type-4 and type-5 prostheses in 61 @entity2 in 54 @entity0 with @entity1 secondary to @entity6 , @entity5 , or @entity4 . Fifty-seven @entity2 in 50 @entity0 were followed for a mean of 11.1 years (10 to 13). The mean age of the @entity0 at operation was 53 years (31 to 70). Functional evaluation using the Merle d'Aubign   and Postel hip score showed a 77% success rate. Radiological loosening occurred in three femoral (5%) and 16 acetabular components (28%). Autologous femoral head grafts were used in 18 @entity2 and became incorporated, giving mechanical support to the socket except for one which occupied a large weight-bearing area and eventually collapsed. The mean @entity3 wear was 1.1 mm (0 to 3.6) and the mean wear rate was 0.10 mm/year (0 to 0.31). A high rate of wear correlated with calcar resorption (p > 0.002) but not with acetabular loosening. There was no breakage of a ceramic head. Study of the ceramic heads and @entity3 sockets retrieved after ten years showed excellent surface roughness, sphericity, and bending strength for the heads but scratches and voids were seen on the sockets.

title: XXXX sockets and alumina ceramic heads in cemented total hip arthroplasty. A ten-year study.

answer: @entity3


abstract: UNASSIGNED: Oncogene-induced senescence (OIS) serves as an initial barrier to @entity0 development, being proposed as a possible explanation for the usually benign behavior of the @entity2 . We aimed to explore the immunohistochemical expression of the OIS markers, senescence-associated lysosomal b-galactosidase (SA-b-GAL), @entity3 , and @entity5 in different types of 345 @entity2 and compared it with the expression in the normal pituitary and in the specimens from the repeated surgeries. SA-b-GAL was overexpressed in the @entity2 , compared to the normal pituitaries. @entity4 ( @entity4 ) producing @entity1 showed the strongest SA-b-GAL, with densely granulated (DG)- @entity4 @entity1 more reactive than the sparsely granulated (SG). Nuclear @entity5 was decreased in the @entity1 , except for the SG-GH @entity1 that had higher @entity5 than the normal pituitaries and the other @entity1 . @entity3 was significantly lower in the @entity1 , without type-related differences. SA-b-GAL was slightly lower and @entity3 slightly higher in the recurrences. Our findings indicate alterations of the senescence program in the different types of @entity2 . Activation of senescence in the @entity2 presents one possible explanation for their usually benign behavior, at least in the @entity4 @entity1 that show a synchronous increase of two OIS markers. However, subdivision into @entity4 @entity1 subtypes reveals differences that reflect complex regulatory mechanisms influenced by the interplay between the granularity pattern and the hormonal factors, with possible impact on the different clinical behavior of the SG- and DG- @entity4 @entity1 subtypes. @entity3 seems to have a more prominent role in the pituitary tumorigenesis than in the senescence. Recurrent growth in a subset of the @entity2 is not associated with consistent changes in the senescence pattern.

title: Oncogene-Induced Senescence in XXXX -an Immunohistochemical Study.

answer: @entity2


abstract: BACKGROUND: The diagnosis of @entity3 is made using clinical findings and investigations. Recent studies have suggested that serum @entity2 , a cheap and simple biochemical test, is a positive predictor in the diagnosis of appendiceal perforation and may be more specific than @entity5 ( @entity5 ) and white cell count (WCC). The aim of this study was to investigate the utility of the serum @entity2 level in @entity0 with suspected acute but non-perforative @entity4 . METHODS: A retrospective chart review of 213 @entity0 who presented with suspected @entity4 in a 6-month period to Nambour General Hospital was performed. Serum @entity2 , WCC and @entity5 were recorded and analysed as to their utility in relation to the final diagnosis. RESULTS: A total of 196 @entity0 underwent an appendicectomy and 41 of these were negative. The specificity of hyperbilirubinaemia for @entity4 overall was 0.83 with a positive predictive value ( @entity6 ) of 0.86, compared with @entity5 (specificity 0.40, @entity6 0.75) and WCC (specificity 0.67, @entity6 0.85). The area under the receiver operating characteristic curve for @entity2 was 0.6289 compared to 0.6171 for @entity5 and 0.7219 for WCC. A subgroup analysis of those with @entity1 demonstrated a @entity6 for @entity2 of 0.66 compared to 0.58 for WCC and 0.34 for @entity5 in agreement with the literature. Subgroup analysis of hyperbilirubinaemia in @entity4 demonstrated a @entity6 of 0.81 compared to @entity5 (0.71) and WCC (0.82). CONCLUSION: @entity2 had a higher specificity than @entity5 and WCC overall in @entity0 with @entity4 . Hyperbilirubinaemia had a high @entity6 in @entity0 with @entity4 .

title: Hyperbilirubinaemia: its utility in non-perforated XXXX .

answer: @entity4


abstract: UNASSIGNED: Continuing medical education (CME) is challenging and often has limited impact on clinician behavior or @entity0 outcomes. This study examined the impact of an online Qstream education program on senior clinicians to determine its utility for increasing clinician knowledge about the latest guidelines regarding genetic assessment and consideration of genetic testing for @entity0 with particular types of @entity1 . @entity0 were recruited into a pilot study that involved responding to case-based scenarios at spaced and repeated intervals. At the completion of the program, semi-structured interviews were conducted to ascertain the impact on their knowledge and referral behavior. Findings from interviews were subject to thematic analysis that involved the identification of categories and themes. Twenty-one @entity0 commenced the program, seventeen completed and twelve participated in semi-structured interviews. Thematic analysis yielded several themes including knowledge change, curriculum and format and changes in referral patterns. A majority of @entity0 (n   =   10) agreed the program had helped update their knowledge about referring @entity0 , and eight agreed they would now change their referral patterns. The use of QStream as an approach to CME has significant advantages when working with busy clinicians. QStream has a well accepted format and most @entity0 indicated it is very appropriate for disseminating updates to clinical guidelines and protocols. It is important to supplement CME programs with other implementation techniques, such as audit and feedback as multifaceted approaches are more likely to result in behavior change.

title: New Approaches to Continuing Medical Education: a QStream (spaced education) Program for Research Translation in XXXX .

answer: @entity1


abstract: We have used apolipoprotein genes to investigate the signal transduction mechanisms involved in the control of intestinal specific gene expression. The @entity0 @entity3 , @entity6 , and apoAIV genes are tandemly organized within a 15-kb DNA segment and are expressed predominantly in the liver and intestine. Transient transfection of various @entity0 @entity3 gene plasmid constructs into @entity0 @entity1 (HepG2) and @entity2 (Caco-2) cells showed that @entity3 gene transcription is under the control of two separate and distinct cell-specific promoters. The region between @entity4 -192 and -41 is essential for expression in HepG2 cells, whereas the region from -595 to -192 is essential for expression in Caco-2 cells. A third 0.6 kb DNA fragment in the @entity6 gene promoter region, approximately 5 kb down-stream from the @entity0 @entity3 gene, enhances transcription mediated by either of these two tissue-specific @entity3 promoters. In Caco-2 cells, expression of the @entity3 gene and activation by the distal enhancer required the presence of a nuclear hormone receptor response element (NHRRE) located in the -214 to -192 @entity3 promoter region. Overexpression of the orphan receptor @entity5 ( @entity5 ), which binds to the NHRRE, dramatically stimulates @entity3 gene expression in Caco-2 cells but not in HepG2 cells. Maximal stimulation of transcription by @entity5 in Caco-2 cells required the presence of both the intestinal specific promoter, the NHRRE, and distal enhancer elements. Transactivation by @entity5 thus appears to result from functional synergy between the NHRRE binding @entity5 and distal DNA elements containing intestinal-specific DNA binding activities. The @entity3 gene provides a model system to define the mechanism(s) governing intestinal cell specific gene regulation and the role of nuclear hormone receptors in the establishment and regulation of enterocytic gene transcription.

title: Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, XXXX .

answer: @entity5


abstract: AIMS: To identify the histological changes in @entity2 over the first few weeks after the start of @entity5 treatment and to examine their relationship to reversal reaction. METHODS: Sequential skin biopsy during treatment with multiple drug therapy. In this study, a series of 28 @entity0 was studied, from whom two or more biopsies were taken at two week intervals. Fourteen @entity0 had @entity7 ( @entity7 ) and 14 had @entity6 ( @entity6 ). RESULTS: In most cases, @entity4 fraction and bacterial index fell during treatment, the bacterial index being less sensitive than the @entity4 fraction. Since the biopsies were fixed in buffered @entity3 and processed through to paraffin wax, little immunohistochemistry was feasible. However, there was strong evidence of immune activation, with increased expression of HLA-DR in the @entity4 of @entity6 and @entity7 cases: the epidermis also expressed HLA-DR in several @entity0 . Such changes may reflect gamma IFN production from @entity4 lymphocytes. @entity0 with reversal reaction often showed HLA-DR expression on admission which decreased with corticosteroid treatment. CONCLUSIONS: The results suggest that activation of cell mediated immunity in @entity1 occurs during treatment with multiple drug therapy and may not be restricted to those with clinical evidence of reversal reaction.

title: Effects of treatment on the histopathology of XXXX .

answer: @entity5


abstract: Establishment of right ventricular-pulmonary arterial continuity with autologous tissue, avoiding the use of prosthetic conduit, is presented. From February 1992 through March 1993, 22 @entity0 with @entity3 and @entity1 underwent reparative operation at The Heart institute of Japan. In 20 @entity0 out of the 22 @entity0 , the right ventricular-pulmonary arterial continuity was successfully established with either direct @entity2 or insertion of tailored autologous pericardial tube. The morphology of the right ventricular-pulmonary arterial discontinuity comprised of valvular and infundibular @entity3 in seven, truncal @entity3 in nine, and failed extracardiac conduit in four. In @entity0 with relatively short distance between right ventricle and pulmonary artery, the pulmonary artery was retracted and anastomosed directly to the cranial margin of the ventriculotomy incision to serve as a smooth floor made of autologous tissue. In @entity0 with long distance, tailored autologous pericardial tube was interposed between right ventricle and pulmonary artery instead of using prosthetic conduit. Both techniques were completed by mono- or bicuspid anterior patch made of @entity4 pericardial conduit. There were no early and late deaths. Postoperative catheterization data showed satisfactory reduction of right ventricular pressure with the right-to-left ventricular systolic pressure ratio ranging from 0.42 to 0.69 (average 0.52) in direct @entity2 group and 0.43 to 0.48 (average 0.45) in autologous pericardial tube group, and the pressure gradient across right ventricular outflow tract ranged from 1 to 15 (average 8) mmHg and 1 to 15 (average 5.8), respectively. The distributing frequency of late complication, mainly conduit obstruction, of prosthetic materials prompted us to use autologous tissue.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Reconstruction of pulmonary trunk in @entity3 and XXXX utilizing autologous tissue].

answer: @entity1


abstract: Establishment of right ventricular-pulmonary arterial continuity with autologous tissue, avoiding the use of prosthetic conduit, is presented. From February 1992 through March 1993, 22 @entity0 with @entity3 and @entity1 underwent reparative operation at The Heart institute of Japan. In 20 @entity0 out of the 22 @entity0 , the right ventricular-pulmonary arterial continuity was successfully established with either direct @entity2 or insertion of tailored autologous pericardial tube. The morphology of the right ventricular-pulmonary arterial discontinuity comprised of valvular and infundibular @entity3 in seven, truncal @entity3 in nine, and failed extracardiac conduit in four. In @entity0 with relatively short distance between right ventricle and pulmonary artery, the pulmonary artery was retracted and anastomosed directly to the cranial margin of the ventriculotomy incision to serve as a smooth floor made of autologous tissue. In @entity0 with long distance, tailored autologous pericardial tube was interposed between right ventricle and pulmonary artery instead of using prosthetic conduit. Both techniques were completed by mono- or bicuspid anterior patch made of @entity4 pericardial conduit. There were no early and late deaths. Postoperative catheterization data showed satisfactory reduction of right ventricular pressure with the right-to-left ventricular systolic pressure ratio ranging from 0.42 to 0.69 (average 0.52) in direct @entity2 group and 0.43 to 0.48 (average 0.45) in autologous pericardial tube group, and the pressure gradient across right ventricular outflow tract ranged from 1 to 15 (average 8) mmHg and 1 to 15 (average 5.8), respectively. The distributing frequency of late complication, mainly conduit obstruction, of prosthetic materials prompted us to use autologous tissue.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Reconstruction of pulmonary trunk in XXXX and @entity1 utilizing autologous tissue].

answer: @entity3


abstract: Fifty-seven @entity0 with advanced measurable urothelial tract @entity1 , 52 of whom had an adequate trial, were treated weekly with 3 to 4 mg. per m.2 vinblastine and 30 to 40 mg. per m.2 @entity2 . Of 3 @entity0 with unidimensional parameters 2 showed improvement lasting 16 and 27 months, which was documented by serial cystoscopic examinations. An additional 2 @entity0 had measurable disease that could have been encompassed in a preoperative radiotherapy field. Both @entity0 are free of disease at more than 12 and 14 months, respectively. Of the 47 @entity0 with bidimensionally measurable parameters 19 (40 per cent) achieved a complete or partial remission lasting a median of 8 months, with a range of 1 to 24 months. Of 25 @entity0 with intra-abdominal or pelvic disease 7 achieved a complete or partial remission and 5 also had a minor remission. Of note, 18 of 38 @entity0 who had received no prior chemotherapy achieved a remission versus 1 of 9 who had been treated previously (p equals 0.06). Responders frequently obtained another remission with subsequent chemotherapy (4 of 9 versus 0 of 16, p equals 0.03). Responders lived 14 months versus 8 months for nonresponders (p equals 0.02). Four responders had brain metastases compared to none of 28 nonresponders. The combination of @entity3 and @entity2 is a well tolerated, effective outpatient regimen for @entity0 with urothelial tract @entity1 .

title: @entity3 and XXXX for advanced bladder cancer.

answer: @entity2


abstract: Fifty-seven @entity0 with advanced measurable urothelial tract @entity1 , 52 of whom had an adequate trial, were treated weekly with 3 to 4 mg. per m.2 vinblastine and 30 to 40 mg. per m.2 @entity2 . Of 3 @entity0 with unidimensional parameters 2 showed improvement lasting 16 and 27 months, which was documented by serial cystoscopic examinations. An additional 2 @entity0 had measurable disease that could have been encompassed in a preoperative radiotherapy field. Both @entity0 are free of disease at more than 12 and 14 months, respectively. Of the 47 @entity0 with bidimensionally measurable parameters 19 (40 per cent) achieved a complete or partial remission lasting a median of 8 months, with a range of 1 to 24 months. Of 25 @entity0 with intra-abdominal or pelvic disease 7 achieved a complete or partial remission and 5 also had a minor remission. Of note, 18 of 38 @entity0 who had received no prior chemotherapy achieved a remission versus 1 of 9 who had been treated previously (p equals 0.06). Responders frequently obtained another remission with subsequent chemotherapy (4 of 9 versus 0 of 16, p equals 0.03). Responders lived 14 months versus 8 months for nonresponders (p equals 0.02). Four responders had brain metastases compared to none of 28 nonresponders. The combination of @entity3 and @entity2 is a well tolerated, effective outpatient regimen for @entity0 with urothelial tract @entity1 .

title: XXXX and @entity2 for advanced bladder cancer.

answer: @entity3


abstract: The feeding habits of Anopheles sacharovi under natural conditions and in feeding rooms were investigated by use of the gel diffusion technique. Mosquitoes were collected from various villages of Cukurova and also from feeding rooms especially prepared for these experiments. @entity0 , @entity2 , @entity4 , @entity5 , @entity6 , and @entity8 were used as hosts in these rooms. The results showed that An. sacharovi is a zoophilic species. The females preferred @entity8 when @entity0 , @entity2 , @entity4 , @entity5 , and @entity6 were equally available. Their preference changed to @entity6 , @entity2 , and @entity4 in the absence of @entity8 . The @entity7 ( @entity7 ) was always smaller than 1 for @entity0 in habitats offering a choice of hosts. The @entity0 blood index was high only in @entity0 dwellings. In other habitats numbers of mosquitoes feeding on animals were higher than on humana. Although the @entity0 blood index was low, An. sacharovi is the principal @entity0 @entity3 vector in @entity1 partly because a significant proportion of those resting in @entity0 dwellings have fed upon the occupants, and partly because of the uneven distribution of @entity0 and animal hosts.

title: Bloodfeeding behavior of Anopheles sacharovi in XXXX .

answer: @entity1


abstract: UNASSIGNED: Cardiovascular @entity0 take @entity1 ( @entity5 ) for preventing @entity2 and other @entity3 . It is already known that in some @entity0 this therapy is not effective. The aim of this study was to assess the percentage of @entity5 resistance on the sample of @entity0 with coronary artery bypass grafting. Our study included 105 @entity0 with coronary artery bypass grafting treated with @entity5 150mg/day or lesser. Platelet aggregation was measured by serum @entity4 level as well as impedance aggregometry from whole blood to determine @entity5 antiaggregation effect. The percentage of @entity5 resistance was 41.9% with impedance aggregometry, and after determining the serum @entity4 level this percentage was only 8.6%. The correlation between these two methods was weak (r=0.443; P<0.0001). @entity3 complications still occur in @entity5 -treated @entity0 because some @entity0 are resistant to @entity5 therapy. It would be useful to monitor the effectiveness of @entity5 therapy and give another antiaggregation drug to these @entity0 to reduce adverse events. The problem is which test is ideal because different tests show different percentages of @entity5 resistance.

title: The monitoring of antiaggregation effect of XXXX therapy by measuring serum @entity4 in @entity0 with coronary artery bypass grafting.

answer: @entity1