abstract: INTRODUCTION: @entity3 ( @entity3 ) tend to occur in Asian @entity0 with prolonged @entity5 exposure. Hip geometry is thought to contribute to the risk of @entity3 formation. We examined the hip structural geometry parameters in Asian female chronic @entity5 users who sustained an @entity3 and compared them to chronic @entity5 users who did not sustain any @entity3 (NFF) and @entity5 - @entity4  ve @entity0 who sustained an @entity3 ( @entity3 ). MATERIALS _ METHODS: Thirty-one @entity0 with AFFs were gender and age-matched to 31 @entity0 with NFFs and 49 @entity0 with OFFs. The Hip Structural Analysis parameters analyzed were @entity1 ( @entity1 ), cross-sectional area (CSA; a metric of resistance to axial compression), section modulus (SM; a metric of resistance to tensile loads), @entity2 ( @entity2 ; mean thickness of the femoral cortices), buckling ratio (BR; an index of likelihood of local buckling), and neck shaft angle (NSA; the angle between the neck and shaft axes). The regions analyzed were three cross-sections measured at the narrowest femoral neck diameter, the intertrochanteric area, and the proximal femoral shaft. One-way ANOVA with Bonferroni adjustment for multiple comparisons was used to compare parameters between the three @entity0 groups, with statistical significance defined as p<0.05. RESULTS: There were no statistical differences in parameters between @entity0 with AFFs and @entity0 with NFFs at all measured regions. @entity0 with AFFs and NFFs had statistically higher @entity1 , CSA, @entity2 , SM values and lower BR values at the @entity6 and IT regions than @entity0 with OFFs. Additionally, @entity0 with NFFs had statistically higher SM values at the IT region than @entity0 with OFFs, while @entity0 with AFFs had statistically higher @entity1 , CSA, and @entity2 values at the FS region. All other measured parameters were not statistically different between the groups. CONCLUSIONS: Chronic @entity5 users with and without AFFs had similar femoral structural geometries. Unlike in other populations, varus neck shaft angles were not found to be associated with AFFs in Asian female chronic @entity5 users. Thus, bone cross-sectional geometry is not likely to be associated with AFFs in Asian female chronic @entity5 users. Hip Structural Analysis does not show an increased predilection for tensile failure in AFFs.

title: Bone cross-sectional geometry is not associated with atypical XXXX in Asian female chronic @entity5 users.

answer: @entity3


abstract: UNASSIGNED: Background Elotuzumab, an immunostimulatory monoclonal antibody targeting signaling lymphocytic activation molecule F7 (SLAMF7), showed activity in combination with @entity7 and @entity3 in a phase 1b-2 study in @entity0 with relapsed or refractory multiple @entity5 . Methods In this phase 3 study, we randomly assigned @entity0 to receive either elotuzumab plus @entity7 and @entity3 (elotuzumab group) or @entity7 and @entity3 alone (control group). Coprimary end points were progression-free survival and the overall response rate. Final results for the coprimary end points are reported on the basis of a planned interim analysis of progression-free survival. Results Overall, 321 @entity0 were assigned to the elotuzumab group and 325 to the control group. After a median follow-up of 24.5 months, the rate of progression-free survival at 1 year in the elotuzumab group was 68%, as compared with 57% in the control group; at 2 years, the rates were 41% and 27%, respectively. Median progression-free survival in the elotuzumab group was 19.4 months, versus 14.9 months in the control group (hazard ratio for progression or @entity2 in the elotuzumab group, 0.70; 95% confidence interval, 0.57 to 0.85; P<0.001). The overall response rate in the elotuzumab group was 79%, versus 66% in the control group (P<0.001). Common grade 3 or 4 adverse events in the two groups were @entity6 , @entity4 , fatigue, and @entity1 . Infusion reactions occurred in 33 @entity0 (10%) in the elotuzumab group and were grade 1 or 2 in 29 @entity0 . Conclusions @entity0 with relapsed or refractory multiple @entity5 who received a combination of elotuzumab, @entity7 , and @entity3 had a significant relative reduction of 30% in the risk of disease progression or @entity2 . (Funded by Bristol-Myers Squibb and AbbVie Biotherapeutics; ELOQUENT-2 ClinicalTrials.gov number, NCT01239797 .).

title: Elotuzumab Therapy for Relapsed or Refractory XXXX .

answer: @entity5


abstract: The chronic and recurrent nature of major @entity1 is receiving increasing attention. Approximately eight of ten @entity0 experiencing a major @entity1 will have at least one more episode during their lifetime, i.e. recurrent major @entity1 . In the 1990s, prolonged or lifelong pharmacotherapy emerged as the main therapeutic tool for preventing relapses of @entity1 . This therapeutic approach is based on the effectiveness of antidepressant drugs compared with placebo in decreasing relapse risk and on the improved tolerability profile of the newer antidepressants compared with their older counterparts. However, outcome after discontinuation of antidepressant therapy does not seem to be affected by the duration of administration. Loss of clinical effects, despite adequate compliance, has also emerged as a vexing clinical problem. The use of intermittent pharmacotherapy with follow-up visits is an alternative therapeutic option. This leaves @entity0 with periods free of drugs and adverse effects and takes into account that a high proportion of @entity0 would discontinue the antidepressant anyway. However, the problems of resistance (that a drug treatment may be associated with a diminished chance of response in subsequent treatments in those @entity0 whose symptoms successfully responded to it but who discontinued it) and of discontinuation syndromes are substantial disadvantages of this therapeutic approach. In recent years, several controlled trials have suggested that sequential use of pharmacotherapy in the treatment of the acute @entity1 and psychotherapy in its residual phase may improve long-term outcome. @entity0 , however, need to be motivated for psychotherapy, and skilled therapists have to be available. Despite an impressive amount of research into the treatment of @entity1 , there is still a paucity of studies addressing the specific problems that prevention of recurrent @entity1 entails. It is important to discuss with the @entity0 the various therapeutic options and to adapt strategies to the specific needs of @entity0 .

title: Treatment of recurrent XXXX : a sequential psychotherapeutic and psychopharmacological approach.

answer: @entity1


abstract: OBJECTIVE: Extracorporeal life support has undergone a revolution in the past several years with the advent of new, miniaturized equipment and success in supporting @entity0 with a variety of illnesses. Most experience has come with the use of extracorporeal membrane oxygenation, a modified form of cardiopulmonary bypass that can support the heart, lungs, and circulation for days to months at a time. To describe the recommendations for the use of extracorporeal membrane oxygenation in @entity0 with @entity2 based on a review of the literature and expert opinion. DESIGN: Consensus conference of experts in pediatric @entity1 . METHODS: A panel of 27 experts met over the course of 2 years to develop a @entity2 and to make recommendations regarding treatment and research priorities. The extracorporeal support subgroup comprised two international experts. When published data were lacking, a modified Delphi approach emphasizing strong professional agreement was used. RESULTS: The Pediatric @entity1 Consensus Conference experts developed and voted on a total of 151 recommendations addressing the topics related to @entity2 , 11 of which related to extracorporeal support. All recommendations had agreement, with 10 recommendations (91%) achieving strong agreement. These recommendations included the utilization of extracorporeal support for reversible causes of @entity2 , consideration of quality of life when making the decision to use extracorporeal support, and the use of the Extracorporeal Life Support Organization registry to report all extracorporeal support activity, among others. CONCLUSIONS: Pediatric extracorporeal membrane oxygenation for @entity2 could benefit from more specific data collection and collaboration of focused investigators to establish validated criteria for optimal application of extracorporeal membrane oxygenation and @entity0 management protocols. Until that time, consensus opinion offers some insight into guidelines.

title: Extracorporeal Support in @entity0 With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric XXXX Consensus Conference.

answer: @entity1


abstract: OBJECTIVE: Extracorporeal life support has undergone a revolution in the past several years with the advent of new, miniaturized equipment and success in supporting @entity0 with a variety of illnesses. Most experience has come with the use of extracorporeal membrane oxygenation, a modified form of cardiopulmonary bypass that can support the heart, lungs, and circulation for days to months at a time. To describe the recommendations for the use of extracorporeal membrane oxygenation in @entity0 with @entity2 based on a review of the literature and expert opinion. DESIGN: Consensus conference of experts in pediatric @entity1 . METHODS: A panel of 27 experts met over the course of 2 years to develop a @entity2 and to make recommendations regarding treatment and research priorities. The extracorporeal support subgroup comprised two international experts. When published data were lacking, a modified Delphi approach emphasizing strong professional agreement was used. RESULTS: The Pediatric @entity1 Consensus Conference experts developed and voted on a total of 151 recommendations addressing the topics related to @entity2 , 11 of which related to extracorporeal support. All recommendations had agreement, with 10 recommendations (91%) achieving strong agreement. These recommendations included the utilization of extracorporeal support for reversible causes of @entity2 , consideration of quality of life when making the decision to use extracorporeal support, and the use of the Extracorporeal Life Support Organization registry to report all extracorporeal support activity, among others. CONCLUSIONS: Pediatric extracorporeal membrane oxygenation for @entity2 could benefit from more specific data collection and collaboration of focused investigators to establish validated criteria for optimal application of extracorporeal membrane oxygenation and @entity0 management protocols. Until that time, consensus opinion offers some insight into guidelines.

title: Extracorporeal Support in XXXX With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric @entity1 Consensus Conference.

answer: @entity0


abstract: Multiciliated ependymal cells line the ventricles in the adult brain. Abnormal function or structure of ependymal cilia is associated with various @entity1 . The current ex vivo live imaging of motile ependymal cilia technique allows for a detailed study of ciliary dynamics following several steps. These steps include: @entity0 euthanasia with @entity4 according to protocols of The University of Toledo's Institutional Animal Care and Use Committee (IACUC); craniectomy followed by brain removal and sagittal brain dissection with a vibratome or sharp blade to obtain very thin sections through the brain lateral ventricles, where the ependymal cilia can be visualized. Incubation of the brain's slices in a customized glass-bottom plate containing Dulbecco's Modified Eagle's Medium (DMEM)/High- @entity2 at 37   C in the presence of 95%/5% @entity6 / @entity5 mixture is essential to keep the tissue alive during the experiment. A video of the cilia beating is then recorded using a high-resolution differential interference contrast microscope. The video is then analyzed frame by frame to calculate the ciliary beating frequency. This allows distinct classification of the ependymal cells into three categories or types based on their ciliary beating frequency and angle. Furthermore, this technique allows the use of high-speed fluorescence imaging analysis to characterize the unique intracellular @entity3 oscillation properties of ependymal cells as well as the effect of pharmacological agents on the @entity3 oscillations and the ciliary beating frequency. In addition, this technique is suitable for immunofluorescence imaging for ciliary structure and ciliary protein localization studies. This is particularly important in disease diagnosis and phenotype studies. The main limitation of the technique is attributed to the decrease in live motile cilia movement as the brain tissue starts to die.

title: Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the XXXX Brain.

answer: @entity0


abstract: OBJECTIVE: To provide additional details and evidence behind the recommendations for outcomes assessment of @entity0 with @entity3 from the Pediatric @entity2 Consensus Conference. DESIGN: Consensus conference of experts in pediatric @entity2 . METHODS: A panel of 27 experts met over the course of 2 years to develop a @entity3 and to make recommendations regarding treatment and research priorities. The outcomes subgroup comprised four experts. When published data were lacking, a modified Delphi approach emphasizing strong professional agreement was used. RESULTS: The Pediatric @entity2 Consensus Conference experts developed and voted on a total of 151 recommendations addressing the topics related to @entity3 , seven of which related to outcomes after @entity3 . All seven recommendations had strong agreement. @entity0 with @entity3 continue to have a high mortality, specifically, in relation to certain comorbidities and etiologies related to @entity3 . Comorbid conditions, such as an immunocompromised state, increase the risk of mortality even further. Likewise, certain etiologies, such as @entity1 , also place @entity0 at a higher risk of mortality. Significant long-term effects were reported in adult survivors of @entity3 : diminished lung function and exercise tolerance, reduced quality of life, and diminished neurocognitive function. Little knowledge of long-term outcomes exists in @entity0 who survive @entity3 . Characterization of the longer term consequences of @entity3 in @entity0 is vital to help identify opportunities for improved therapeutic and rehabilitative strategies that will lessen the long-term burden of @entity3 and improve the quality of life in @entity0 . CONCLUSIONS: The Consensus Conference developed pediatric-specific recommendations for @entity3 regarding outcome measures and future research priorities. These recommendations are intended to promote optimization and consistency of care for @entity0 with @entity3 and identify areas of uncertainty requiring further investigation.

title: The Outcomes of @entity0 With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric XXXX Consensus Conference.

answer: @entity2


abstract: OBJECTIVE: To provide additional details and evidence behind the recommendations for outcomes assessment of @entity0 with @entity3 from the Pediatric @entity2 Consensus Conference. DESIGN: Consensus conference of experts in pediatric @entity2 . METHODS: A panel of 27 experts met over the course of 2 years to develop a @entity3 and to make recommendations regarding treatment and research priorities. The outcomes subgroup comprised four experts. When published data were lacking, a modified Delphi approach emphasizing strong professional agreement was used. RESULTS: The Pediatric @entity2 Consensus Conference experts developed and voted on a total of 151 recommendations addressing the topics related to @entity3 , seven of which related to outcomes after @entity3 . All seven recommendations had strong agreement. @entity0 with @entity3 continue to have a high mortality, specifically, in relation to certain comorbidities and etiologies related to @entity3 . Comorbid conditions, such as an immunocompromised state, increase the risk of mortality even further. Likewise, certain etiologies, such as @entity1 , also place @entity0 at a higher risk of mortality. Significant long-term effects were reported in adult survivors of @entity3 : diminished lung function and exercise tolerance, reduced quality of life, and diminished neurocognitive function. Little knowledge of long-term outcomes exists in @entity0 who survive @entity3 . Characterization of the longer term consequences of @entity3 in @entity0 is vital to help identify opportunities for improved therapeutic and rehabilitative strategies that will lessen the long-term burden of @entity3 and improve the quality of life in @entity0 . CONCLUSIONS: The Consensus Conference developed pediatric-specific recommendations for @entity3 regarding outcome measures and future research priorities. These recommendations are intended to promote optimization and consistency of care for @entity0 with @entity3 and identify areas of uncertainty requiring further investigation.

title: The Outcomes of XXXX With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric @entity2 Consensus Conference.

answer: @entity0


abstract: UNASSIGNED: @entity1 that exercise after meals gain less body weight and visceral fat compared to those that exercised before meals under a one meal/exercise time per day schedule. @entity0 generally eat two or three meals per day, and rarely have only one meal. To extend our previous observations, we examined here whether a "two meals, two exercise sessions per day" schedule was optimal in terms of maintaining a healthy body weight. In this experiment, "morning" refers to the beginning of the active phase (the "morning" for nocturnal animals). We found that 2-h feeding before 2-h exercise in the morning and evening (F-Ex/F-Ex) resulted in greater attenuation of high fat diet (HFD)-induced @entity3 compared to other combinations of feeding and exercise under two daily meals and two daily exercise periods. There were no significant differences in total food intake and total wheel counts, but feeding before exercise in the morning groups (F-Ex/F-Ex and F-Ex/Ex-F) increased the morning wheel counts. These results suggest that habitual exercise after feeding in the morning and evening is more effective for preventing HFD-induced @entity3 . We also determined whether there were any correlations between food intake, wheel rotation, visceral fat volume and skeletal muscle volumes. We found positive associations between gastrocnemius muscle volumes and morning wheel counts, as well as negative associations between morning food intake volumes/body weight and morning wheel counts. These results suggest that morning exercise-induced increase of muscle volume may refer to anti- @entity2 . Evening exercise is negatively associated with fat volume increases, suggesting that this practice may counteract fat deposition. Our multifactorial analysis revealed that morning food intake helps to increase exercise, and that evening exercise reduced fat volumes. Thus, exercise in the morning or evening is important for preventing the onset of @entity2 .

title: Eating meals before wheel-running exercise attenuate high fat diet-driven XXXX in @entity1 under two meals per day schedule.

answer: @entity2


abstract: UNASSIGNED: @entity1 that exercise after meals gain less body weight and visceral fat compared to those that exercised before meals under a one meal/exercise time per day schedule. @entity0 generally eat two or three meals per day, and rarely have only one meal. To extend our previous observations, we examined here whether a "two meals, two exercise sessions per day" schedule was optimal in terms of maintaining a healthy body weight. In this experiment, "morning" refers to the beginning of the active phase (the "morning" for nocturnal animals). We found that 2-h feeding before 2-h exercise in the morning and evening (F-Ex/F-Ex) resulted in greater attenuation of high fat diet (HFD)-induced @entity3 compared to other combinations of feeding and exercise under two daily meals and two daily exercise periods. There were no significant differences in total food intake and total wheel counts, but feeding before exercise in the morning groups (F-Ex/F-Ex and F-Ex/Ex-F) increased the morning wheel counts. These results suggest that habitual exercise after feeding in the morning and evening is more effective for preventing HFD-induced @entity3 . We also determined whether there were any correlations between food intake, wheel rotation, visceral fat volume and skeletal muscle volumes. We found positive associations between gastrocnemius muscle volumes and morning wheel counts, as well as negative associations between morning food intake volumes/body weight and morning wheel counts. These results suggest that morning exercise-induced increase of muscle volume may refer to anti- @entity2 . Evening exercise is negatively associated with fat volume increases, suggesting that this practice may counteract fat deposition. Our multifactorial analysis revealed that morning food intake helps to increase exercise, and that evening exercise reduced fat volumes. Thus, exercise in the morning or evening is important for preventing the onset of @entity2 .

title: Eating meals before wheel-running exercise attenuate high fat diet-driven @entity2 in XXXX under two meals per day schedule.

answer: @entity1


abstract: We investigated whether adults with healthy vision can move their eyes toward an informative target area that is initially hidden by a gaze-contingent @entity1 in the periphery when they are under time pressure. In the experimental task, @entity0 had to perform an object-comparison task requiring a same-different judgment about two silhouettes. One silhouette was visible, whereas the other was hidden under the @entity1 . Despite time pressure and the presence of the visible silhouette, most @entity0 were able to move their eyes toward the informative region to reveal the hidden silhouette. Saccades to the hidden stimulus occurred when the visible stimulus was presented directly opposite in either fixed or variable locations and when the visible stimulus was presented at an adjacent location. Older @entity0 were also able to perform this task. First saccades in the direction of the hidden stimulus had longer latencies compared with saccades toward the visible stimulus. This suggests the use of a deliberate, nonreflexive saccade strategy ("stop before you saccade"). A subset of @entity0 occasionally made curved saccades that were aimed first toward the visible stimulus and then toward the hidden stimulus. We discuss the implications of our findings for @entity0 who have a biological @entity1 , for example, in @entity2 .

title: Stop before you saccade: Looking into an artificial XXXX .

answer: @entity1


abstract: Coccolithophores impact the ocean @entity1 cycle principally through the generation of @entity2 during @entity4 production. Coccolithophore biomineralization has been examined most extensively in Pleurochrysis carterae and @entity3 both of which produce mineralized scales-coccoliths-composed of elaborate calcite crystals attached to an underlying organic base plate. Calcification of preformed base plates is mediated by acidic polysaccharides and occurs in Golgi-derived structures known as mineralizing vesicles. In Pleurochrysis a high capacity @entity0 -binding polysaccharide PS2 is required for efficient nucleation of calcitic protocrystals. A galacturonomannan PS3 is required for the growth and transformation of the protocrystals into a massive double disc of calcite. The genes that regulate expression of the glycans have not yet been identified. In addition to the coccolith-bearing diploid phases, Pleurochrysis and Emiliania possess both haploid and diploid non-calcifying stages, which are self-perpetuating via binary fission. One non-calcifying Pleurochrysis phase fails to synthesis PS2 and spontaneously reverts to the mineralizing morphotype in laboratory cultures. As yet, there is little information on environmental factors that effect the expression or silencing of calcifying genes or favor the growth of calcifying over non-calcifying phases. These issues will need extensive investigation, if we are to appreciate the role of coccolithophores in the regulation of atmospheric @entity2 levels.

title: Regulation of XXXX formation in coccolithophores.

answer: @entity4


abstract: The in vitro protein-chemical features and the molecular background of @entity3 ( @entity3 ), a heritable disorder of collagen I metabolism, have been elucidated in recent years. The aim of our study was to find the prevalence of @entity4 ( @entity4 ) and other @entity2 in 88 @entity0 with @entity3 , to compare clinical with radiologic abnormalities, and to correlate these clinical/radiologic findings with the results of gel electrophoresis and molecular studies of collagen I. Twenty-eight percent of @entity3 @entity0 had @entity4 . Most @entity0 with @entity4 had radiologic abnormalities, but some @entity0 had radiologic signs compatible with @entity4 , but no clinical signs of @entity4 . @entity3 @entity0 with @entity4 were more severely affected by @entity3 than those without @entity4 . In @entity5 and IV, in contrast, there was no difference in overall severity between @entity0 with and without @entity4 . @entity4 was not associated with any particular molecular aberration in any @entity3 type. If defining @entity4 from the presence of both clinical and radiologic signs, collagen I produced by cultured fibroblasts was qualitatively abnormal from all @entity3 @entity0 with @entity4 . Some @entity3 @entity0 had dental abnormalities not resembling @entity4 . A qualitative collagen abnormality could not be found in any of these @entity0 . Denticles, i.e., calcifications within the @entity1 , were found more frequently in @entity3 @entity0 than in control subjects.

title: Dental manifestations of XXXX and abnormalities of collagen I metabolism.

answer: @entity3


abstract: UNASSIGNED: Dropout from mental health treatment poses a substantial problem, but rates vary substantially across studies and diagnoses. Focused reviews are needed to provide more detailed estimates for specific areas of research. Randomized clinical trials involving individual psychotherapy for @entity1 are ubiquitous and important, but empirical data on average dropout rates from these studies is lacking. We conducted a random-effects meta-analysis of 54 such studies (N=5852) including 80 psychotherapy conditions, and evaluated a number of predictors of treatment- and study-level dropout rates. Our overall weighted dropout estimates were 19.9% at the study level, and 17.5% for psychotherapy conditions specifically. Therapy orientation did not significantly account for variance in dropout estimates, but estimates were significantly higher in psychotherapy conditions with more @entity0 of minority racial status or with @entity2 . Treatment duration was also positively associated with dropout rates at trend level. Studies with an inactive control comparison had higher dropout rates than those without such a condition. Limitations include the inability to test certain potential predictors (e.g., socioeconomic status) due to infrequent reporting. Overall, our findings suggest the need to consider how specific @entity0 and study characteristics may influence dropout rates in clinical research on individual therapy for @entity1 .

title: Dropout from individual psychotherapy for XXXX : A meta-analysis of randomized clinical trials.

answer: @entity1


abstract: A second nationwide survey was conducted to determine the outcome of pregnancy in long-term survivors of @entity2 and to clarify the influence of treatment on the offspring of long-term survivors. In July 1996, 336 survey responses were received from the 498 Japanese institutions surveyed. A total of 89 cases (39 spouses of male @entity0 and 50 female @entity0 ) who had babies during their first remission were analyzed, including 43 @entity0 from the first survey in 1991. Median age at the birth of first baby was 30.7 years for male @entity0 and 28.6 years for female @entity0 . A total of 109 of the 117 pregnancies resulted in live births and eight resulted in abortions. A total of 58 cases had single @entity0 and 23 cases had two or more, generally from separate pregnancies, but including two pairs of twins. The @entity0 was male in 59 cases, female in 37 and gender was not reported in 13 cases. Ages of @entity0 ranged from 2 months to 20 years at the time of this study and all @entity0 were in good health. There were two minor anomalies, both of which were surgically corrected. Of the 81 parents bearing live @entity0 , 75 remained in complete remission. Five fathers died (four of relapse and one of another disease). In conclusion, there was no apparent @entity3 or @entity1 in the @entity0 of long-term survivors with @entity2 .

title: Pregnancy among long-term survivors of XXXX . A second nationwide survey.

answer: @entity2


abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and antiparkinsonian medication (Meds) have proved to be effective therapies for treating @entity2 in @entity1 . However, it is not currently known how or to what extent STN stimulation alters the control signals to agonist and antagonist muscles to change movement speed. Our objective was to investigate movement speed along with the amplitude and temporal features of EMG activity to determine how and to what extent these parameters are changed by DBS and medication. Nine @entity0 with @entity1 were studied following neurosurgery that implanted high-frequency stimulating electrodes in the STN. The experiments for the @entity0 were performed in each of four treatment conditions: (i) OFF treatment; (ii) STN DBS; (iii) Meds; and (iv) Meds plus STN DBS. Also, a group of age- and gender-matched control subjects were examined. Medication and DBS had similar effects in that both treatments increased movement speed, increased the amplitude of the first agonist burst, increased burst duration, reduced the number of agonist bursts, reduced cocontraction, increased the size of the antagonist EMG, and reduced the centroid time of the antagonist EMG. When DBS and medication were combined, only temporal measures of burst duration and the number of agonist bursts were different from the medication alone condition. There was a positive association between the level of @entity2 OFF treatment and the level of @entity2 following DBS and medication. The movement speed of neurologically normal control subjects' was over 40% higher during both flexion and extension movements when compared with the @entity0 during Meds plus STN DBS. The changes in the muscle activation patterns provide a mechanism of action for the pharmacological and surgical interventions used to treat @entity2 in @entity1 . However, despite the success of medication and DBS at improving @entity2 in @entity0 with @entity1 , @entity0 ' movement speed was not restored to normal due to limitations in the amplitude and temporal scaling of the agonist and antagonist bursting pattern. These findings suggest a link between basal ganglia function in scaling both the amplitude and temporal parameters of the input to the motor neuron pool.

title: Effects of deep brain stimulation and medication on @entity2 and muscle activation in XXXX .

answer: @entity1


abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and antiparkinsonian medication (Meds) have proved to be effective therapies for treating @entity2 in @entity1 . However, it is not currently known how or to what extent STN stimulation alters the control signals to agonist and antagonist muscles to change movement speed. Our objective was to investigate movement speed along with the amplitude and temporal features of EMG activity to determine how and to what extent these parameters are changed by DBS and medication. Nine @entity0 with @entity1 were studied following neurosurgery that implanted high-frequency stimulating electrodes in the STN. The experiments for the @entity0 were performed in each of four treatment conditions: (i) OFF treatment; (ii) STN DBS; (iii) Meds; and (iv) Meds plus STN DBS. Also, a group of age- and gender-matched control subjects were examined. Medication and DBS had similar effects in that both treatments increased movement speed, increased the amplitude of the first agonist burst, increased burst duration, reduced the number of agonist bursts, reduced cocontraction, increased the size of the antagonist EMG, and reduced the centroid time of the antagonist EMG. When DBS and medication were combined, only temporal measures of burst duration and the number of agonist bursts were different from the medication alone condition. There was a positive association between the level of @entity2 OFF treatment and the level of @entity2 following DBS and medication. The movement speed of neurologically normal control subjects' was over 40% higher during both flexion and extension movements when compared with the @entity0 during Meds plus STN DBS. The changes in the muscle activation patterns provide a mechanism of action for the pharmacological and surgical interventions used to treat @entity2 in @entity1 . However, despite the success of medication and DBS at improving @entity2 in @entity0 with @entity1 , @entity0 ' movement speed was not restored to normal due to limitations in the amplitude and temporal scaling of the agonist and antagonist bursting pattern. These findings suggest a link between basal ganglia function in scaling both the amplitude and temporal parameters of the input to the motor neuron pool.

title: Effects of deep brain stimulation and medication on XXXX and muscle activation in @entity1 .

answer: @entity2


abstract: HYPOTHESIS: Intractable @entity2 , especially of the slow-transit subtype, may represent several pathophysiologic entities with a common final symptomatic appearance. An overall impairment of colonic propulsive activity may represent a major disease mechanism. DESIGN: Case series. SETTING: Tertiary university hospital. SUBJECTS: Twenty-nine severely @entity2 @entity0 with clinical and homogeneous features of @entity1 that were unresponsive to conventional medical measures and 16 age-matched healthy volunteers. INTERVENTIONS: Twenty-four-hour manometric recordings obtained in @entity0 and controls to assess high- and low-amplitude colonic propulsive activity. RESULTS: Compared with controls, @entity0 showed heavily reduced high-amplitude propagated activity (average, <1 event per subject per day). No differences were found in low-amplitude propagated activity. CONCLUSIONS: @entity0 with severe @entity2 that is refractory to medical treatment may display an important reduction of colonic forceful propulsive activity. This may justify a surgical approach, which may offer the best results in such @entity0 . It is, however, important to obtain thorough physiologic documentation before such a drastic approach is considered. The residual low-amplitude propulsive activity might represent a partially compensatory mechanism in these @entity0 . Studies in more homogeneous groups of such @entity0 are needed.

title: Colonic propulsive impairment in intractable XXXX .

answer: @entity1


abstract: HYPOTHESIS: An aggressive strategy that includes extended lymphadenectomy and vein resection may improve the results of surgical treatment of @entity2 . DESIGN: Nonrandomized control trial. SETTING: Tertiary care referral center. @entity0 : The study included 149 consecutive @entity0 undergoing macroscopically curative resection for @entity1 from January 1, 1988, to December 31, 1998. INTERVENTIONS: A standard resection was performed in 122 cases; an extended lymphadenectomy in 37. Twenty-four @entity0 underwent venous resection. MAIN OUTCOME MEASURES: Data on surgical mortality, morbidity, and postoperative outcome, pathological findings, and long-term survival were analyzed. RESULTS: In-hospital and 60-day operative mortality was 5.4%. Morbidity was 37.5%. Mortality, morbidity, and postoperative stay were nonsignificantly modified by extended lymphadenectomy or venous resection. Extended resection permitted the identification of a significantly higher percentage of nodal metastases beyond the peripancreatic node groups. In @entity0 undergoing vein resection, a significantly higher rate of positive retroperitoneal margin was found. In the 100 @entity0 with @entity1 , the median overall survival and the 5-year actuarial survival rate were 15 months and 8.4%, respectively. A trend toward a better survival was observed in the first 2 years after operation in the extended resection group compared with the standard resection group. Nodal status was the most powerful predictor of overall survival by multivariate analysis. CONCLUSIONS: Extended lymphadenectomy and vein resection did not adversely affect postoperative mortality and morbidity. @entity0 who required a vein resection were less likely to receive a microscopically curative pancreatectomy. Extended resection permitted better pathological staging and was associated with an early advantage in survival, but long-term survival was possible only in @entity0 with favorable prognostic factors.

title: Extended lymphadenectomy and vein resection for XXXX : outcomes and implications for therapy.

answer: @entity2


abstract: OBJECTIVE: To discuss the clinical pathologic features and therapeutic method of the primary @entity3 in ear, nose, pharynx, larynx. METHOD: One case of atypical @entity1 in larynx is treated by epiglottidectomy. One case of atypical @entity1 in rhinopharynx is treated by radiotherapy. One case of typical @entity1 in middle ear is treated by exploratory incision and radical mastoidectomy. One case of @entity4 in right nasal cavity is treated by resection and radiotherapy. RESULT: The @entity0 of atypical @entity1 in larynx died after 5 years and the @entity0 of atypical @entity1 in rhinopharynx died after 1 year. The @entity0 of typical @entity1 in middle ear was followed-up 3 years and the @entity0 of @entity4 in right nasal cavity was followed-up 2 years, and the @entity2 didn't recrudesce. CONCLUSION: The primary @entity3 in ear, nose, pharynx, larynx is classified in three states: typical @entity1 , atypical @entity1 and @entity4 . Typical @entity1 is a kind of low @entity1 and @entity4 is a kind of high @entity1 and atypical @entity1 is a kind of medium @entity1 . The chief therapeutic method of the primary @entity3 in ear, nose, pharynx, larynx is surgical intervention.

title: [Four cases of primary XXXX in ear, nose, pharynx and larynx].

answer: @entity3


abstract: Currently there are three major surgical approaches into the sphenoid sinus during transsphenoidal microsurgery. The first approach is the sublabial incision with submucous resection along the nasal septum. It is particularly advantageous in @entity0 with small nasal apertures, in pediatric @entity0 , and for large @entity1 extending into the cavernous sinuses or into the clivus. The second approach, the transnasal submucous tunnel, is presently the most frequent technique used, although it provides the narrowest operation field. The third technique is the direct transnasal approach. This method is less destructive to structures in the nasal cavity and less time-consuming. In the period of 20 months the authors performed 81 transsphenoidal microsurgical operations in 44 @entity0 and 37 @entity0 . @entity2 was the most frequent indication for surgery in 42 cases, followed by hormonal abnormality in 24 @entity0 . The sublabial approach was used in 69 cases, the technique of transnasal submucous tunnel in 10 @entity0 , and the direct transnasal approach in 2 cases. The authors encountered no short-term or long-term complications related to various surgical approaches to the sphenoid sinus.

title: [Surgical approach to the sphenoid sinus in microsurgery of hypophyseal XXXX ].

answer: @entity1


abstract: @entity2 is the single most common cause of @entity1 worldwide. Although infection prevention and eradication of established infection offer the potential for cure, these strategies are neither feasible nor practical for widespread implementation. @entity0 most at risk need to be identified and targeted for treatment. For disease to occur, bacterial, environmental, and nutritional factors require a genetically susceptible host. Consequently, it is important to understand how the organism interacts with the host to cause disease. Only through an understanding of what places a @entity0 at risk can we hope to identify susceptible @entity0 early enough in disease to have an impact on their outcome. The immune response is the single most important determinant of disease. Single nucleotide polymorphisms within the promoter region of several critical proinflammatory genes dramatically increase the risk of Helicobacter-associated @entity1 . Additionally, environmental and dietary factors may modulate the immune response or directly influence key apoptotic and proliferative signaling cascades to alter disease presentation. Lastly, concurrent disease states may have a dramatic impact on the host response to @entity2 and influence disease. An understanding of the immune signaling pathways responsible for disease and the ways in which environmental risk factors influence these pathways will allow identification of populations that are most at risk and targeted prevention and treatment strategies.

title: Helicobacter and XXXX disease mechanisms: host response and disease susceptibility.

answer: @entity1


abstract: OBJECTIVE: The aim of this in vitro study was to use high-resolution micro-computed tomography (micro-CT) and @entity0 ( @entity0 ) to compare the efficacy of four irrigation techniques [needle, ultrasonic, EndoActivator, and photon-induced photoacoustic streaming (PIPS)] in removing @entity1 ( @entity2 ) from the root canal and isthmus of maxillary premolars. METHODS: Twenty-four maxillary first premolars were selected based on the presence of isthmus regions on micro-CT scans. Root canals were instrumented with an F2 file using ProTaper rotary instruments and filled with @entity2 paste. Samples were stored at 37  C and 100% humidity for 1 week and randomly divided into four groups (n=6 each), according to irrigation technique. Samples were scanned with micro-CT before instrumentation, after @entity2 filling, and after irrigation. @entity2 reduction in the coronal, middle, and apical thirds and in the isthmus were assessed with three-dimensional image analysis. Next, specimens were split longitudinally, and canal walls were examined with @entity0 for @entity2 residues. Data were statistically evaluated with the Kruskal-Wallis and Mann-Whitney tests (p=0.05). RESULTS: The PIPS and ultrasonic groups showed greater @entity2 reduction in the apical third and higher cleanliness of the isthmus than the EndoActivator and needle irrigation groups (p<0.05). @entity2 residue scores in the PIPS and ultrasonic groups were significantly lower than those in the EndoActivator and needle groups in all regions of the root canals (p<0.05). There was no significant difference between PIPS and ultrasonic groups (p>0.05), or between EndoActivator and needle groups (p>0.05). CONCLUSIONS: PIPS and ultrasonic irrigation more effectively removed @entity2 from the main canal and isthmus in maxillary premolars than did EndoActivator or needle irrigation.

title: Efficacy of Needle, Ultrasonic, and Endoactivator Irrigation and Photon-Induced Photoacoustic Streaming in Removing XXXX from the Main Canal and Isthmus: An In Vitro Micro-Computed Tomography and Scanning Electron Microscopy Study.

answer: @entity1


abstract: OBJECTIVES: Inflammation is important in the development of @entity4 . Matrix metalloproteinases (MMPs) and @entity2 which participate in collagen degradation are pathological factors in plaque vulnerability as an important mechanism underlying @entity6 . This study investigated whether @entity1 is related to the onset of @entity6 . METHODS: This study included 56 @entity0 with @entity6 (ACS group), 104 @entity0 with chronic @entity3 (S group), and 38 control subjects with no evidence of @entity5 (C group). High-sensitivity C-reactive protein (hs-CRP), @entity7 , and @entity2 were measured in peripheral blood samples. Soluble adhesion molecules ( @entity9 , @entity8 ) were also measured as inflammatory markers. RESULTS: The hs-CRP level was significantly higher in the ACS group (44.5 mg/l) than in the S group (2.1 mg/l) and the C group (0.6 mg/l) (p < 0.0001). The @entity7 level was also significantly higher in the ACS group (333.8 ng/ml) than in the S group (110.8 ng/ml) and the C group (72.0 ng/ml) (p < 0.0001). The @entity9 level was significantly higher in the ACS group (506.5 ng/ml) than in the C group (448.8 ng/ml) (p < 0.05). The @entity8 level and the @entity2 level did not differ between the groups. There was a significant positive correlation between the level of hs-CRP and the level of the collagen degradation product @entity7 (r = 0.52) in all subjects. CONCLUSIONS: These results suggest that plaque destabilized by @entity7 produced in response to @entity1 participates in the mechanism of @entity6 .

title: Involvement of @entity1 in acute coronary syndromes assessed by levels of high-sensitivity C-reactive protein, matrix metalloproteinase-9 and soluble XXXX .

answer: @entity9


abstract: OBJECTIVES: Inflammation is important in the development of @entity4 . Matrix metalloproteinases (MMPs) and @entity2 which participate in collagen degradation are pathological factors in plaque vulnerability as an important mechanism underlying @entity6 . This study investigated whether @entity1 is related to the onset of @entity6 . METHODS: This study included 56 @entity0 with @entity6 (ACS group), 104 @entity0 with chronic @entity3 (S group), and 38 control subjects with no evidence of @entity5 (C group). High-sensitivity C-reactive protein (hs-CRP), @entity7 , and @entity2 were measured in peripheral blood samples. Soluble adhesion molecules ( @entity9 , @entity8 ) were also measured as inflammatory markers. RESULTS: The hs-CRP level was significantly higher in the ACS group (44.5 mg/l) than in the S group (2.1 mg/l) and the C group (0.6 mg/l) (p < 0.0001). The @entity7 level was also significantly higher in the ACS group (333.8 ng/ml) than in the S group (110.8 ng/ml) and the C group (72.0 ng/ml) (p < 0.0001). The @entity9 level was significantly higher in the ACS group (506.5 ng/ml) than in the C group (448.8 ng/ml) (p < 0.05). The @entity8 level and the @entity2 level did not differ between the groups. There was a significant positive correlation between the level of hs-CRP and the level of the collagen degradation product @entity7 (r = 0.52) in all subjects. CONCLUSIONS: These results suggest that plaque destabilized by @entity7 produced in response to @entity1 participates in the mechanism of @entity6 .

title: Involvement of XXXX in acute coronary syndromes assessed by levels of high-sensitivity C-reactive protein, matrix metalloproteinase-9 and soluble @entity9 .

answer: @entity1


abstract: OBJECTIVE: To investigate the early recognition and management of milder cases of @entity6 in pregnancy (AFLP). METHODS: Twelve cases of AFLP treated in our hospital during the past two and half years were retrospectively studied with emphasis on symptoms, laboratory findings, liver biopsy and maternal complications. The 12 cases were classified into 2 groups. Group 1, 6 cases of advanced AFLP diagnosed clinically, were treated in the first year of the study. Group 2, 6 cases of milder AFLP diagnosed by postpartum liver biopsy, were treated during the last one and half years of the study. RESULTS: The mean gestational age at onset was 34 +/- 3 weeks. In the early stage, all cases had malaise, @entity2 , @entity8 and @entity12 followed by @entity7 in the third trimester of pregnancy. Laboratory findings included raised transaminases (< or = 300 IU/L) and total serum @entity4 (32.5-510.8 micro mol/L) levels, @entity11 (18-30 g/L), hypofibrogenemia (< 2.4 g/L), prolonged prothrombin time and prolonged partial thromboplastin time. Maternal complications were frequent including @entity0 (9), @entity5 (9), @entity10 (7), @entity1 (3), hematemesis (4), @entity9 (6), and postpartum @entity3 (5). Cesarean sections were performed in 7 cases. In group 2, both mother and fetuses had 100% survival. However, the mortality of the mothers and fetuses in group 1 were both 50%. CONCLUSIONS: With increasing awareness, especially in the early recognition of AFLP cases and prompt progressive management, including early termination of pregnancy and large dose infusion of fresh frozen plasma, the prognosis of AFLP is obviously improved. Percutaneous liver biopsy should be done when the coagulation tests became normal and the amounts of @entity5 decreased after delivery.

title: [ XXXX in pregnancy: a clinicopathologic study].

answer: @entity6


abstract: OBJECTIVE: To investigate the prognosis change and prognostic factors of @entity2 in recent over twenty years. METHODS: One hundred and fourty @entity0 with @entity2 were analyzed. They were divided into two groups based on their operation time. 56 @entity0 operated before Jan. 1980 were included in the first group, and the other 84 @entity0 in the second group. Kaplan-Meier survival curves of the two groups were calculated, and Cox model was used to evaluate the prognostic factors of the disease at univariate and multivariate levels using SPSS and SURVCALC software. RESULTS: There was no pathological difference in between the two groups, but the @entity0 in the second group received more aggressive chemotherapy. The overall 1-, 2-, and 5-year survival rates were 61.2%, 32.1%, and 8.5%, respectively. In the first group they were 42.3%, 29.6% and 4.5% respectively and in the second group 69.3%, 36.2%, and 11.2% respectively. The prognosis of the @entity0 in the second group was better than that in the first group, P < 0.05. Univariate analysis revealed that stage, grade, @entity1 size and chemotherapy were significant predictors of @entity0 ' outcome. COX regression analysis identified that they were all independent prognostic factors. The @entity0 with advanced, low grade, @entity1 (> 2 cm) had poor prognosis. The prognosis of the @entity0 who received equal or more than four, especially six cycles combined chemotherapy was improved. CONCLUSION: The prognosis of the @entity0 with advanced @entity2 has improved in recent over 10 years, higher optimal cytoreductive rate and equal or more than six cycles combined chemotherapy are important measures for the better prognosis of advanced @entity2 .

title: [Prognosis and prognostic factor analysis XXXX ].

answer: @entity2


abstract: Mesenchymal stem cells (MSC) possess a range of immunomodulatory properties which they exert through soluble mediators and through direct cell-cell contact. Due to these immune regulatory properties, the safety and clinical efficacy of MSC treatment has been tested in a number of @entity3 . In this review we analyze the current data from early phase trials into @entity1 , @entity4 , and @entity2 . In general, no adverse side effects were observed in @entity0 treated with MSC; however, their clinical efficacy is difficult to interpret. Systemic or site-specific administration of MSC has been reported to exert potent immunomodulatory effects in 7 of the 11 trials discussed. Nonetheless, the mechanism(s) by which MSC exert their regulatory effects in vivo remain largely unknown. We discuss potential limitations or safety concerns associated with MSC therapy, including the heterogeneity of MSC and their potential contribution to disease pathogenesis, which need to be considered when designing future clinical trials, along with the need to standardize trial design. Although we are bridging the translational gap between scientific observations on MSC function and clinical applications for therapy, our understanding of basic MSC biology is still limited. Despite these issues, large, double-blinded, multicenter clinical trials are already underway. Further research into the endogenous function of MSC is required to elucidate the mechanism by which therapeutic MSC are acting.

title: Mesenchymal Stem Cell Therapy for XXXX : Risks and Rewards.

answer: @entity3


abstract: There is increasing evidence that the cerebellum has a role in the pathophysiology of primary @entity6 and might provide an intervention target for non-invasive brain stimulation to improve function of the affected hand. The primary objective of this study was to determine if cerebellar transcranial direct current stimulation (tDCS) improves handwriting and cyclic drawing kinematics in @entity0 with hand @entity3 , by reducing cerebellar-brain inhibition (CBI) evoked by @entity5 ( @entity5 ). Eight @entity0 with @entity3 (5 writer's @entity3 , 3 @entity7 ) and eight age-matched controls completed the study and underwent cerebellar anodal, cathodal and sham tDCS in separate sessions. @entity3 severity was assessed using the Writer's Cramp Rating Scale (WRCS) and the Arm @entity2 Scale (ADDS). The kinematic measures that differentiated the groups were; @entity1 frequency during handwriting and fast cyclic drawing and average pen pressure during light cyclic drawing. @entity5 measures of cortical excitability were no different between @entity0 with @entity4 and controls. There was a moderate, negative relationship between @entity5 -evoked CBI at baseline and the WRCS in @entity3 . Anodal cerebellar tDCS reduced handwriting @entity1 frequency and average pen pressure, and increased speed and reduced pen pressure during fast cyclic drawing. Kinematic measures were not associated with a decrease in CBI within an individual. In conclusion, cerebellar anodal tDCS appeared to improve kinematics of handwriting and circle drawing tasks; but the underlying neurophysiological mechanism remains uncertain. A study in a larger homogeneous population is needed to further investigate the possible therapeutic benefit of cerebellar tDCS in @entity3 .

title: Anodal transcranial direct current stimulation to the cerebellum improves handwriting and cyclic drawing kinematics in XXXX .

answer: @entity6


abstract: In this work, a multi-wavelength model (MWM) is developed. It uses fluorescence bands in the @entity6 (FA) spectrum that quench upon binding of inorganic @entity2 to FA. Quenching data at pH values of 5, 6, and 7 are placed in sets, containing fluorescence measures at select wavelengths versus added @entity0 (CM). Intensity data of wavelength @entity4 are obtained from 25 nm constant offset synchronous fluorescence spectra (SyF), in which are observed distinct peaks (lambda(ex) = 415 nm, lambda(em) = 440 nm; and lambda(ex) = 471 nm, lambda(em) = 496 nm). Wavelength @entity5 intensity data are obtained from the FA fluorescence excitation and emission maxima (lambda(ex) = 335 nm, lambda(em) = 450 nm; and X(ex) = 471 nm, lambda(em) = 496 nm). Application of MWM shows that the multi-wavelength data sets characterize ligands of different binding strength (log K(x)) and concentration (C(Lx)). Corresponding to pH values of 5, 6, and 7, mean and standard deviation values for wavelength @entity4 are log K(415/440) = 4.66 (0.12), 5.03 (0.12), and 5.05 (0.08), log K(471/496) = 4.93 (0.06), 5.27 (0.11), and 5.39 (0.09), C(415/440) = 3.1 (1.5), 10.9 (4.5), and 7.9 (3.9) microM, C(471/496) = 14.3 (3.0), 1.7 (0.6), and 1.4 (0.5) microM. And for wavelength @entity5 , log K(335/450) = 4.50 (0.03), 4.96 (0.27), and 5.22 (0.08), log K(471/496) = 5.02 (0.04), 5.42 (0.32), and 5.71 (0.09), C(335/450) = 8.8 (0.5), 21.9 (7.9), and 18.7 (0.3) microM, C(471/496) = 21.0 (2.5), 7.17 (1.2), and 7.09 (0.3) micrpM. The ability of the 415/440 nm SyF transect to characterize the main excitation and emission maximum of FA at 335/440 nm is evaluated. Relatively low concentration values returned by the model for this transect (415/440 nm) suggest that it is not entirely illustrative of the maximum. The model predictive capability is verified at pH 6 with two fluorescing @entity2 chelating organic compounds, @entity3 and @entity1 . This test confirms that the model is capable of providing good estimates of equilibrium binding parameters from multi-wavelength measurements of a mixed ligand system.

title: Multi-wavelength fluorescence-quenching model for determination of @entity2 conditional stability constants and ligand concentrations of XXXX .

answer: @entity6


abstract: In this work, a multi-wavelength model (MWM) is developed. It uses fluorescence bands in the @entity6 (FA) spectrum that quench upon binding of inorganic @entity2 to FA. Quenching data at pH values of 5, 6, and 7 are placed in sets, containing fluorescence measures at select wavelengths versus added @entity0 (CM). Intensity data of wavelength @entity4 are obtained from 25 nm constant offset synchronous fluorescence spectra (SyF), in which are observed distinct peaks (lambda(ex) = 415 nm, lambda(em) = 440 nm; and lambda(ex) = 471 nm, lambda(em) = 496 nm). Wavelength @entity5 intensity data are obtained from the FA fluorescence excitation and emission maxima (lambda(ex) = 335 nm, lambda(em) = 450 nm; and X(ex) = 471 nm, lambda(em) = 496 nm). Application of MWM shows that the multi-wavelength data sets characterize ligands of different binding strength (log K(x)) and concentration (C(Lx)). Corresponding to pH values of 5, 6, and 7, mean and standard deviation values for wavelength @entity4 are log K(415/440) = 4.66 (0.12), 5.03 (0.12), and 5.05 (0.08), log K(471/496) = 4.93 (0.06), 5.27 (0.11), and 5.39 (0.09), C(415/440) = 3.1 (1.5), 10.9 (4.5), and 7.9 (3.9) microM, C(471/496) = 14.3 (3.0), 1.7 (0.6), and 1.4 (0.5) microM. And for wavelength @entity5 , log K(335/450) = 4.50 (0.03), 4.96 (0.27), and 5.22 (0.08), log K(471/496) = 5.02 (0.04), 5.42 (0.32), and 5.71 (0.09), C(335/450) = 8.8 (0.5), 21.9 (7.9), and 18.7 (0.3) microM, C(471/496) = 21.0 (2.5), 7.17 (1.2), and 7.09 (0.3) micrpM. The ability of the 415/440 nm SyF transect to characterize the main excitation and emission maximum of FA at 335/440 nm is evaluated. Relatively low concentration values returned by the model for this transect (415/440 nm) suggest that it is not entirely illustrative of the maximum. The model predictive capability is verified at pH 6 with two fluorescing @entity2 chelating organic compounds, @entity3 and @entity1 . This test confirms that the model is capable of providing good estimates of equilibrium binding parameters from multi-wavelength measurements of a mixed ligand system.

title: Multi-wavelength fluorescence-quenching model for determination of XXXX conditional stability constants and ligand concentrations of @entity6 .

answer: @entity2


abstract: @entity1 ( @entity2 ) is a highly sensitizing industrial chemical that is known to covalently bind to endogenous proteins. The aim of this study was to determine the binding sites of @entity2 to human serum albumin (HSA). Conjugates between HSA and @entity2 , at two different molar ratios, were synthesized under physiological conditions. The conjugates were digested with trypsin and Pronase E to obtain specific peptides and @entity0 , which were separated by liquid chromatography (LC). Fractions containing modified peptides were detected through quantification of hydrolysable @entity2 using LC coupled to a triple quadrupole mass spectrometer with electrospray ionization. Modified residues in albumin were identified by sequence analyses using nanoelectrospray quadrupole time-of-flight mass spectrometry. A total of 36 @entity2 adducts were found in the HSA- @entity2 conjugate with 10 times molar excess of added @entity2 . In the conjugate with a molar ratio of 1:0.1 of added @entity2 , seven @entity2 adducts were found bound to Lys(137) (domain IB), Lys(190), Lys(199) and Lys(212) (domain IIA), Lys(351) (domain IIB), and Lys(432) and Lys(436) (domain IIIA). Moreover, several of these adducted albumin peptides were detected in nasal lavage fluid from one volunteer exposed to @entity2 . The binding sites of @entity2 to HSA have been determined, thus identifying potential allergenic chemical structures. This knowledge generates the possibility of developing methods for the biological monitoring of @entity2 exposure by analysing tryptic peptides including these binding sites.

title: Determination of XXXX adducts to human serum albumin.

answer: @entity1


abstract: Historically, fashioning an auricle for a @entity0 born with @entity1 has been one of the most challenging endeavors in the repertoire of reconstructive surgeons. Despite many ideas advanced on types of materials for the auricular framework, the hands-down favorite and today's medium of choice is autogenous costal cartilage. A subject that remains up for discussion, however, is the question of growth potential in these cartilaginous frameworks. Popularization of the surgical technique for auricular reconstruction has led to much bandying about of opinions on this very important question of growth. Although previous reports allude to the probability of an increase in auricular size after reconstruction, this report is the first to document changes in auricular size with measurements taken directly from @entity0 at the time of graft implantation and during subsequent long-term follow-up. The goals of this study are to define the behavior of the autogenous framework after reconstruction of the microtic auricle. This information serves to clarify the issue of proper framework sizing and to make evident the early age at which reconstruction can begin. The records of @entity0 who underwent costal cartilage auricular reconstruction for grade III @entity1 between 1990 and 1996 were reviewed, and a cohort of 10 @entity0 was chosen for inclusion based on availability for follow-up and lack of any interval modifications of their cartilaginous framework. The average age was 6.7 years, and the average time interval from initial reconstruction to follow-up was 3.2 years. Measurements of the auricular framework height and width were taken at implantation and at time of final follow-up, and measurements were recorded of the normal ears of @entity0 with unilateral @entity1 . The mean auricular size was examined for significance of interval change using the two-sample Student's t tests, assuming unequal variances. The results revealed an average height increase of 5 mm (10.4 percent) in the study population. Auricular width changes averaged 2.75 mm (7.02 percent). Growth trends revealed a distinct tendency toward increasing auricular framework size over time, with slowing as @entity0 neared adolescence. Comparison of the reconstructed auricle to the normal ear of each @entity0 with unilateral @entity1 showed that the reconstructed ear paralleled the growth of the normal side, with no statistically significant differences in height or width at follow-up. This is the first report of auricular framework behavior based on @entity0 having direct measurement of their framework initially and in long-term follow-up. This @entity0 sample underscores a clear pattern of growth in the reconstructed auricles paralleling that of the normal ears. The implications of this finding are important in that the initial oversizing of the framework becomes unnecessary. Moreover, the decision as to age at initial reconstruction is not affected by anticipated growth rates.

title: Framework growth after reconstruction for XXXX : is it real and what are the implications?

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) and dominant R wave in lead V1 (RV1) post-biventricular pacing (BiVp) are associated with better clinical outcomes. However, some @entity0 continue to deteriorate despite these favorable electrocardiographic changes. OBJECTIVE: We tested the hypothesis that baseline @entity2 and post-BiVp RV1 are associated with better cardiac function and clinical outcomes in @entity0 with progressive deterioration in @entity1 after BiVp ("clinical nonresponders") than in @entity0 without these electrocardiographic criteria. METHODS: Consecutive @entity0 with advanced @entity1 and BiVp were included. An increase in R-wave amplitude of over 4.5 times the baseline value was defined as RV1. Clinical outcome was survival free of heart transplantation and/or implantation of mechanical circulatory support. RESULTS: A total of 179 (100 (56%) with @entity2 ; 79 (44%) with non- @entity2 ) @entity0 with advanced @entity1 and BiVp were included. Of the 100 @entity0 with @entity2 , 67 (67%) developed RV1 (group 1) but 33 (33%) @entity0 did not develop RV1 (group 2). Of the 79 @entity0 with non- @entity2 , 49 (62%) developed RV1 (group 3) and the remaining 30 (38%) @entity0 did not develop RV1 (group 4). Changes in left ventricular ejection fraction and left ventricular end-systolic volume index were not significant in group 1, but deteriorated in the other groups (P < .05). The change in left ventricular end-systolic volume index was associated with the change in QRS duration and absence of RV1 (P < .01). Clinical outcome was most favorable in group 1 ( @entity2 and RV1). Changes in left ventricular ejection fraction, tricuspid annular plane systolic excursion, and right atrial pressure were associated with clinical outcomes. CONCLUSION: Despite progressive deterioration in @entity1 , @entity0 with @entity2 and RV1 post-BiVp demonstrate more stable cardiac function and more favorable clinical outcomes than did @entity0 with non- @entity2 with or without RV1 post-BiVp.

title: Progression of XXXX after biventricular pacing: Is there a subgroup of "favorable nonresponders"?

answer: @entity1


abstract: In essence, this paper describes the model-based interpretation of measurements in order to gain insight into physiological processes. The paper extends the mathematical model developed previously to control and monitor a @entity4 @entity0 . The extension considers two further yet different types of @entity1 . The model is applied to simulate, first, the total serum @entity3 kinase levels, which then are matched to the observed values. The outcomes of this approach yield considerable information about the reactions taking place including various concentration levels over time such as @entity2 . The changes in the @entity1 are estimated. Examples illustrate how the model may be used to assess, for a single @entity0 , the maximum reduction of the @entity1 whilst keeping the @entity2 concentration as low as possible. The model has been successfully used to interpret variations in daily heart rate measurements of a @entity4 @entity0 . Consequently, it is shown how daily heart rate measurements may now be used to complement the control and monitoring of the @entity4 @entity0 . The model is used to explore multi- @entity0 statistics. It shows the dangers of using such an approach. The model illustrates the need for longitudinal studies.

title: XXXX --a further investigation.

answer: @entity4


abstract: BACKGROUND: The long-term safety and efficacy of long-acting injectable @entity8 , the first long-acting second-generation antipsychotic, were evaluated in stable @entity0 with @entity5 . METHOD: After a 2-week run-in period during which @entity0 with DSM-IV @entity5 received flexible doses of 1 to 6 mg of oral @entity8 , @entity0 received injections of 25 mg, 50 mg, or 75 mg of long-acting @entity8 every 2 weeks for 12 months. Severity of @entity1 was assessed with the Extrapyramidal Symptom Rating Scale (ESRS), and efficacy was assessed with the Positive and Negative Syndrome Scale (PANSS). This study was conducted from March 29, 1999 to July 19, 2000. RESULTS: The subjects were 615 @entity0 with @entity5 who received at least 1 injection of long-acting @entity8 . The 12-month trial was completed by 65% of @entity0 . Treatment was discontinued because of adverse events in 5% of @entity0 . @entity1 as adverse events were reported by 25% of the @entity0 . Severity of @entity1 (according to ESRS scores) was low at baseline and decreased in each of the groups during the 12 months. The other most common adverse events were @entity3 in 24%, @entity2 in 21%, @entity7 in 17%, and @entity6 in 14% of the @entity0 . @entity4 was associated with the injections. Severity of symptoms of @entity5 was improved in each group, with significant reductions in PANSS total scores (p <.01) and positive (p <.01) and negative (p <.001) factor scores. CONCLUSION: In terms of both safety and efficacy, symptomatically stable @entity0 with @entity5 benefit from being switched to long-acting injectable @entity8 .

title: Treatment of XXXX with long-acting injectable @entity8 : a 12-month open-label trial of the first long-acting second-generation antipsychotic.

answer: @entity5


abstract: BACKGROUND: The long-term safety and efficacy of long-acting injectable @entity8 , the first long-acting second-generation antipsychotic, were evaluated in stable @entity0 with @entity5 . METHOD: After a 2-week run-in period during which @entity0 with DSM-IV @entity5 received flexible doses of 1 to 6 mg of oral @entity8 , @entity0 received injections of 25 mg, 50 mg, or 75 mg of long-acting @entity8 every 2 weeks for 12 months. Severity of @entity1 was assessed with the Extrapyramidal Symptom Rating Scale (ESRS), and efficacy was assessed with the Positive and Negative Syndrome Scale (PANSS). This study was conducted from March 29, 1999 to July 19, 2000. RESULTS: The subjects were 615 @entity0 with @entity5 who received at least 1 injection of long-acting @entity8 . The 12-month trial was completed by 65% of @entity0 . Treatment was discontinued because of adverse events in 5% of @entity0 . @entity1 as adverse events were reported by 25% of the @entity0 . Severity of @entity1 (according to ESRS scores) was low at baseline and decreased in each of the groups during the 12 months. The other most common adverse events were @entity3 in 24%, @entity2 in 21%, @entity7 in 17%, and @entity6 in 14% of the @entity0 . @entity4 was associated with the injections. Severity of symptoms of @entity5 was improved in each group, with significant reductions in PANSS total scores (p <.01) and positive (p <.01) and negative (p <.001) factor scores. CONCLUSION: In terms of both safety and efficacy, symptomatically stable @entity0 with @entity5 benefit from being switched to long-acting injectable @entity8 .

title: Treatment of @entity5 with long-acting injectable XXXX : a 12-month open-label trial of the first long-acting second-generation antipsychotic.

answer: @entity8


abstract: @entity6 , including @entity1 , are @entity0 in which tau protein accumulates as a consequence of alterations in its metabolism. At least three different types of alterations have been described; in some cases, an aberrant mRNA splicing of tau exon 10 occurs; in other cases, the disorder is a consequence of missense mutations and, in most cases, aberrant tau hyperphosphorylation takes place. Glycogen synthase kinase-3 (GSK-3) has emerged as a key kinase that is able to interact with several proteins involved in the etiology of @entity1 and other @entity6 . Here, we have evaluated whether GSK-3 is also able to modulate tau-mRNA splicing. Our data demonstrate that GSK-3 inhibition in cultured neurons affects tau splicing resulting in an increase in tau mRNA containing exon 10. Pre-mRNA splicing is catalyzed by a multimolecular complex including members of the @entity3 / @entity2 -rich (SR) family of splicing factors. Immunofluorescence studies showed that after GSK-3 inhibition, @entity4 , a member of the SR family, is redistributed and enriched in nuclear speckles and colocalizes with the kinase. Furthermore, immunoprecipitated @entity4 is phosphorylated by recombinant @entity5 . Phosphorylation of a peptide from the SR domain by GSK-3 revealed that the peptide needs to be prephosphorylated, suggesting the involvement of a priming kinase. Our results demonstrate that GSK-3 plays a crucial role in tau exon 10 splicing, raising the possibility that GSK3 could contribute to @entity6 via aberrant tau splicing.

title: Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of @entity4 . Implications for XXXX .

answer: @entity1


abstract: @entity6 , including @entity1 , are @entity0 in which tau protein accumulates as a consequence of alterations in its metabolism. At least three different types of alterations have been described; in some cases, an aberrant mRNA splicing of tau exon 10 occurs; in other cases, the disorder is a consequence of missense mutations and, in most cases, aberrant tau hyperphosphorylation takes place. Glycogen synthase kinase-3 (GSK-3) has emerged as a key kinase that is able to interact with several proteins involved in the etiology of @entity1 and other @entity6 . Here, we have evaluated whether GSK-3 is also able to modulate tau-mRNA splicing. Our data demonstrate that GSK-3 inhibition in cultured neurons affects tau splicing resulting in an increase in tau mRNA containing exon 10. Pre-mRNA splicing is catalyzed by a multimolecular complex including members of the @entity3 / @entity2 -rich (SR) family of splicing factors. Immunofluorescence studies showed that after GSK-3 inhibition, @entity4 , a member of the SR family, is redistributed and enriched in nuclear speckles and colocalizes with the kinase. Furthermore, immunoprecipitated @entity4 is phosphorylated by recombinant @entity5 . Phosphorylation of a peptide from the SR domain by GSK-3 revealed that the peptide needs to be prephosphorylated, suggesting the involvement of a priming kinase. Our results demonstrate that GSK-3 plays a crucial role in tau exon 10 splicing, raising the possibility that GSK3 could contribute to @entity6 via aberrant tau splicing.

title: Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of XXXX . Implications for @entity1 .

answer: @entity4


abstract: We report the use of stereotactic radiosurgery delivered through an adapted linear accelerator [stereotactic multiple arc radiation therapy (SMART)] for @entity4 not cured by conventional therapy. All 21 @entity0 had undergone conventional radiotherapy (45-50 Gy); 18 had also undergone prior surgery. This cohort comprised 13 @entity0 with somatotrope @entity3 , four with @entity3 , one with a lactotrope @entity3 , and three with nonfunctioning @entity4 (median follow-up: 33 months, range: 3-72 months). SMART has proven effective, safe, and rapidly acting. We observed an accelerated reduction in GH and @entity2 levels in @entity5 , with normalization of GH and @entity2 levels in 58%. Mean GH fell from 21.1 mU/liter to 7.9 mU/liter (7 ng/ml to 2.6 ng/ml, P < 0.01, median 25 months) faster than our predicted fall to 50% at 2 yr with conventional radiotherapy. Mean @entity2 fell from 624 ng/ml to 384 ng/ml (P < 0.001). @entity1 growth was controlled in two of three nonfunctioning @entity4 , and three of four @entity3 . There were no adverse effects from SMART. Notably there have been no visual sequelae or further loss of anterior pituitary function in this heavily pretreated group. Our data indicate that SMART is an effective complementary therapy for @entity4 that have displayed a suboptimal response to conventional therapy including external irradiation.

title: Stereotactic radiosurgery XVI: a treatment for previously irradiated XXXX .

answer: @entity4


abstract: UNASSIGNED: After @entity2 , persistent @entity1 extraction deficit despite the apparent adequate recovery of systemic hemodynamic and @entity1 -derived variables has been a source of uncertainty and controversy. Dysfunction of @entity1 transport pathways during intensive care underlies the sequelae that lead to organ failure, and the limitations of techniques used to measure tissue oxygenation in vivo have contributed to the lack of progress in this area. Novel techniques have provided detailed quantitative insight into the determinants of microcirculatory and mitochondrial oxygenation. These techniques, which are based on the @entity1 -dependent quenching of phosphorescence or delayed luminescence are briefly reviewed. The application of these techniques to animal models of @entity2 and resuscitation revealed the heterogeneous nature of @entity1 distributions and the alterations in @entity1 distribution in the microcirculation and in mitochondria. These studies identified functional shunting in the microcirculation as an underlying cause of @entity1 extraction deficit observed in states of @entity2 and resuscitation. The translation of these concepts to the bedside has been enabled by our development and clinical introduction of hand-held microscopy. This tool facilitates the direct observation of the microcirculation and its alterations at the bedside under the conditions of @entity2 and resuscitation. Studies identified loss of coherence between the macrocirculation and the microcirculation, in which resuscitation successfully restored systemic circulation but did not alleviate microcirculatory perfusion alterations. Various mechanisms responsible for these alterations underlie the loss of hemodynamic coherence during unsuccessful resuscitation procedures. Therapeutic resolution of persistent heterogeneous microcirculatory alterations is expected to improve outcomes in @entity3 @entity0 .

title: Microcirculatory and mitochondrial hypoxia in sepsis, XXXX , and resuscitation.

answer: @entity2


abstract: @entity4 2 @entity1 is characterized by decreased secretion of insulin and insulin resistance. @entity11 are drugs to ameliorate insulin resistance. At present, only @entity9 is available in Japan. The first drug of this category, @entity7 , has been withdrawn from market because of its liver @entity3 in a few @entity0 . The decrease in fasting plasma @entity6 begins within 2 weeks and reaches the nadir in 8-12 weeks. Plasma insulin levels usually decrease together with plasma @entity6 . @entity10 drugs are effective in about 50% of type 2 @entity1 @entity0 . The efficacy is higher in @entity0 with @entity2 , high insulin levels and in aged @entity0 and females. The mechanism is thought to be mediated by activation of a nuclear receptor, @entity8 , which is most abundantly expressed in the adipose tissue. Current concept is that, when @entity8 is activated by these drugs, the number of small adipocytes is increased to replace large adipocytes, thereby decreasing the release of @entity5 and FFA from adipose tissue. However, there seems to be a complex relationship between the activity of @entity8 and insulin sensitivity. The effect of these new category drugs should be monitored carefully on a long-term basis.

title: [Insulin sensitizer drugs, XXXX : current state and prospect].

answer: @entity11


abstract: OBJECTIVES: We examined how state characteristics in early life are associated with individual @entity3 later in life. METHODS: We assessed early-life state of residence using the first 3 digits of social security numbers from blue- and white-collar workers from a US manufacturing company. Longitudinal data were available from 1997 to 2012, with 305   936 @entity0 -years of observation. Disease was assessed using medical claims. We modeled associations using pooled logistic regression with inverse probability of censoring weights. RESULTS: We found small but statistically significant associations between early-state-of-residence characteristics and later life @entity2 , @entity1 , and @entity4 . The most consistent associations were with income inequality, percentage non-White, and education. These associations were similar after statistically controlling for individual socioeconomic and demographic characteristics and current state characteristics. CONCLUSIONS: Characteristics of the state in which an individual lives early in life are associated with prevalence of @entity3 later in life, with a strength of association equivalent to genetic associations found for these same health outcomes. (Am J Public Health. Published online ahead of print June 11, 2015: e1-e7. doi:10.2105/AJPH.2014.302547).

title: Early-Life State-of-Residence Characteristics and Later Life XXXX , @entity1 , and @entity4 .

answer: @entity2


abstract: OBJECTIVES: We examined how state characteristics in early life are associated with individual @entity3 later in life. METHODS: We assessed early-life state of residence using the first 3 digits of social security numbers from blue- and white-collar workers from a US manufacturing company. Longitudinal data were available from 1997 to 2012, with 305   936 @entity0 -years of observation. Disease was assessed using medical claims. We modeled associations using pooled logistic regression with inverse probability of censoring weights. RESULTS: We found small but statistically significant associations between early-state-of-residence characteristics and later life @entity2 , @entity1 , and @entity4 . The most consistent associations were with income inequality, percentage non-White, and education. These associations were similar after statistically controlling for individual socioeconomic and demographic characteristics and current state characteristics. CONCLUSIONS: Characteristics of the state in which an individual lives early in life are associated with prevalence of @entity3 later in life, with a strength of association equivalent to genetic associations found for these same health outcomes. (Am J Public Health. Published online ahead of print June 11, 2015: e1-e7. doi:10.2105/AJPH.2014.302547).

title: Early-Life State-of-Residence Characteristics and Later Life @entity2 , @entity1 , and XXXX .

answer: @entity4


abstract: OBJECTIVES: We examined how state characteristics in early life are associated with individual @entity3 later in life. METHODS: We assessed early-life state of residence using the first 3 digits of social security numbers from blue- and white-collar workers from a US manufacturing company. Longitudinal data were available from 1997 to 2012, with 305   936 @entity0 -years of observation. Disease was assessed using medical claims. We modeled associations using pooled logistic regression with inverse probability of censoring weights. RESULTS: We found small but statistically significant associations between early-state-of-residence characteristics and later life @entity2 , @entity1 , and @entity4 . The most consistent associations were with income inequality, percentage non-White, and education. These associations were similar after statistically controlling for individual socioeconomic and demographic characteristics and current state characteristics. CONCLUSIONS: Characteristics of the state in which an individual lives early in life are associated with prevalence of @entity3 later in life, with a strength of association equivalent to genetic associations found for these same health outcomes. (Am J Public Health. Published online ahead of print June 11, 2015: e1-e7. doi:10.2105/AJPH.2014.302547).

title: Early-Life State-of-Residence Characteristics and Later Life @entity2 , XXXX , and @entity4 .

answer: @entity1


abstract: PURPOSE: To compare the ability of standard power Doppler and color harmonic imaging for visualising @entity0 vascularity using ultrasound probes of various frequencies, and to evaluate the influence on diagnostic accuracy using ultrasound contrast agent. MATERIALS AND METHODS: Twenty @entity1 (x = 43.6 +/- 11.7 years) with suspected malignancy of the breast underwent power Doppler to evaluate vascularity and to offer a differential diagnosis of the lesion. Two criteria were used for differential diagnosis: The quantitative extent of vascularity ("percentage vessel area", @entity3 ) and the qualitative assessment of vascular architecture. The following power Doppler modes were compared in every @entity1 : Plain and enhanced (Levovist(R)) 9 MHz and 12 MHz standard power mode and enhanced 9 MHz color harmonic imaging-(CHI). RESULTS: The @entity3 increased from a mean of 2.2 +/- 2.9 % (9 MHz standard plain) via 4.8 +/- 4.1 % (12 MHz standard plain), 9.7 +/- 15.3 % (9 MHz standard enhanced), 17.4 +/- 20.0 % (9 MHz CHI enhanced) up to 19.4 +/- 14.8 % (12 MHz standard enhanced). The perceptibility of the vascular structure was best using the enhanced 12 MHz standard power mode, immediately followed by the enhanced 9 MHz CHI mode. The improved detection of vascular signal did not translate into improved diagnostic accuracy. The highest diagnostic accuracy (95 %) was obtained using the enhanced 9 MHz CHI mode (criterion " @entity3 ") and the enhanced 9 MHz standard power mode (criterion "vascular structure"), whereas the 12 MHz probes delivered insufficient diagnostic accuracy and very low specificity. CONCLUSION: Best quantitative and qualitative visualisation of the @entity2 vascularity was achieved using the enhanced 12 MHz standard power mode. Nevertheless, the highest diagnostic accuracy was obtained using enhanced 9 MHz standard power Doppler and enhanced 9 MHz color harmonic imaging. The visualisation of @entity2 vascularity and, partially, the diagnostic accuracy are improved significantly by color harmonic imaging without changing the probe frequently.

title: [Analysis of vascularity in XXXX --comparison of high frequency ultrasound and contrast-enhanced color harmonic imaging].

answer: @entity0


abstract: INTRODUCTION: Percutaneous core-needle biopsy is widely accepted for preoperative histologic assessment of suspicious @entity4 . The purpose of this study was to asses the impact of continuous sonographic guidance on diagnostic accuracy of large core needle biopsy of palpable @entity4 . METHOD: We analysed 170 @entity4 in a retrospective study. Percutaneous breast biopsies were performed by using a biopsy gun with 14-gauge needles. Eighty-eight biopsies were performed under continuous ultrasound guidance (group II) and 82 biopsies without ultrasound documentation of the procedure (group I). Core needle diagnoses were compared with the @entity1 final tissue diagnosis as based on surgical excisional biopsy. RESULTS: In @entity1 group I, 17 lesions were categorized as @entity0 misses (sensitivity 79 %). The sensitivity in this group showed an obvious dependency on @entity2 size. Among the 17 @entity3 , 13 lesions were 3 cm in mean diameter or smaller. Two false negative findings occurred in group II (sensitivity 98 %), with a @entity2 size of 0.5 and 1.0 cm. CONCLUSION: Sonographic guidance is indispensable to ensure adequate diagnostic accuracy for core-needle biopsy of palpable @entity4 .

title: [Percutaneous core-needle biopsy of palpable XXXX . Do we need ultrasound guidance?].

answer: @entity0


abstract: OBJECTIVES: We examined Hispanic @entity0 's recent risky and protective @entity1 with female partners by acculturation. METHODS: Using the 2006-2010 National Survey of Family Growth, we performed bivariate analyses to compare acculturation groups (Hispanic Spanish-speaking immigrants, Hispanic English-speaking immigrants, Hispanic US natives, and non-Hispanic White @entity0 ) by demographics and recent @entity1 with @entity0 . Multivariable logistic regression models for @entity1 by acculturation group were adjusted for demographics. RESULTS: Compared with Hispanic Spanish-speaking immigrants, non-Hispanic White @entity0 were less likely to report exchange of money or drugs for sex (adjusted odds ratio [AOR]   =   0.3; 95% confidence interval [CI]   =   0.1, 0.9), but were also less likely to report condom use at last vaginal (AOR   =   0.6; 95% CI   =   0.4, 0.8) and anal sex (AOR   =   0.4; 95% CI   =   0.3, 0.7). Hispanic US natives were less likely to report condom use at last vaginal sex than were Spanish-speaking immigrants (AOR   =   0.6; 95% CI   =   0.4, 0.8). English- and Spanish-speaking immigrants did not differ in risky or protective @entity1 . CONCLUSIONS: Our findings suggest that targeted interventions focusing on unique sexual risks and sociodemographic differences by acculturation level, particularly nativity, may be helpful for preventing @entity2 . (Am J Public Health. Published online ahead of print June 11, 2015: e1-e8. doi:10.2105/AJPH.2014.302524).

title: Hispanic XXXX in the United States: Acculturation and Recent Sexual Behaviors With Female Partners, 2006-2010.

answer: @entity0


abstract: OBJECTIVE: It has been demonstrated that chronic @entity2 misusers, who drink at least 60 g of @entity4 per day, are suffering increased postoperative morbidity after various non-pulmonary surgical procedures. The aim of this study was to evaluate the association between @entity2 consumption and postoperative morbidity and mortality after potential curative resection for @entity1 . METHODS: The records of all @entity0 who underwent curative resection for @entity1 in a single University Centre in Cardiothoracic surgery during 1997 and 1998 were retrospectively reviewed. One hundred and seven @entity0 , 42 @entity0 and 65 @entity0 , median age of 64 (33-79) years, were included and subdivided with regard to @entity2 consumption. There were 26 pneumonectomies, 68 lobectomies and 13 lesser resections. Clinical complications occurring within 30 days after surgery and requiring therapy, were registered and subdivided into major, potentially lethal complications, and minor complications. Mortality within 30 days after surgery was also registered. RESULTS: @entity0 drinking at least 5 drinks per day had increased postoperative mortality, 3/13 versus 2/94 (odds ratio (95% confidence limits): 13.80 (2.06-92.68); P=0.007). The rate of major, live threatening complications including @entity3 and @entity5 was significantly increased among @entity0 drinking at least 5 drinks per day 6/13 versus 19/94 (odds ratio (95% confidence limits): 3.38 (1.02-11.25); P=0.047) in univariate analysis. However, in multivariate analysis this association was not significant. CONCLUSION: Postoperative mortality after curative resection for @entity1 was significantly increased among @entity0 drinking at least 5 drinks of @entity2 per day.

title: Impaired postoperative outcome in chronic @entity2 abusers after curative resection for XXXX .

answer: @entity1


abstract: OBJECTIVE: It has been demonstrated that chronic @entity2 misusers, who drink at least 60 g of @entity4 per day, are suffering increased postoperative morbidity after various non-pulmonary surgical procedures. The aim of this study was to evaluate the association between @entity2 consumption and postoperative morbidity and mortality after potential curative resection for @entity1 . METHODS: The records of all @entity0 who underwent curative resection for @entity1 in a single University Centre in Cardiothoracic surgery during 1997 and 1998 were retrospectively reviewed. One hundred and seven @entity0 , 42 @entity0 and 65 @entity0 , median age of 64 (33-79) years, were included and subdivided with regard to @entity2 consumption. There were 26 pneumonectomies, 68 lobectomies and 13 lesser resections. Clinical complications occurring within 30 days after surgery and requiring therapy, were registered and subdivided into major, potentially lethal complications, and minor complications. Mortality within 30 days after surgery was also registered. RESULTS: @entity0 drinking at least 5 drinks per day had increased postoperative mortality, 3/13 versus 2/94 (odds ratio (95% confidence limits): 13.80 (2.06-92.68); P=0.007). The rate of major, live threatening complications including @entity3 and @entity5 was significantly increased among @entity0 drinking at least 5 drinks per day 6/13 versus 19/94 (odds ratio (95% confidence limits): 3.38 (1.02-11.25); P=0.047) in univariate analysis. However, in multivariate analysis this association was not significant. CONCLUSION: Postoperative mortality after curative resection for @entity1 was significantly increased among @entity0 drinking at least 5 drinks of @entity2 per day.

title: Impaired postoperative outcome in chronic XXXX abusers after curative resection for @entity1 .

answer: @entity2


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a @entity5 with a variable and generally aggressive clinical course. So far our knowledge of skin involvement of @entity3 is limited. To understand the clinical and histopathologic features of @entity3 with skin involvement, the files of the Lymph Node Registry Kiel were screened for @entity3 diagnosed in the skin. Over a period of 13 years, 1321 biopsy specimens were diagnosed as @entity3 ; among them, 14 @entity0 (1%) showed skin involvement. Of these, skin was the initial site of manifestation in 6/11 (55%) cases. One @entity0 presented with a skin-limited @entity2 . Furthermore, 7/12 (58%) @entity0 presented with lesions on the leg. The @entity2 were highly proliferative with blastoid cytology in 12/14 (86%) cases. Moreover, the immunophenotype with expression of @entity1 (100%), @entity10 / @entity11 (83%), and IgM (82%) and lack of @entity6 (25%) and @entity7 (0%) closely resembled the features of primary cutaneous diffuse large @entity5 , @entity9 . Solely the expression of @entity8 (100%) and the presence of t(11;14) (100%) allowed a distinction from cases of primary cutaneous diffuse large @entity5 , @entity9 . Only 2 @entity3 cases with skin involvement presented with classical cytology. Interestingly, in these 2 cases skin involvement occurred simultaneously in a lesion of coexisting primary @entity4 . Our data suggest that clinical presentation on the leg and blastoid cytology along with high proliferation and expression of @entity1 , @entity10 / @entity11 , and IgM are typical for @entity3 involving the skin. Lymphomas with these features might be erroneously diagnosed as diffuse large @entity5 , @entity9 , if @entity8 staining is not performed.

title: Skin Involvement of Mantle Cell Lymphoma May Mimic Primary Cutaneous Diffuse Large XXXX , @entity9 .

answer: @entity5


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a @entity5 with a variable and generally aggressive clinical course. So far our knowledge of skin involvement of @entity3 is limited. To understand the clinical and histopathologic features of @entity3 with skin involvement, the files of the Lymph Node Registry Kiel were screened for @entity3 diagnosed in the skin. Over a period of 13 years, 1321 biopsy specimens were diagnosed as @entity3 ; among them, 14 @entity0 (1%) showed skin involvement. Of these, skin was the initial site of manifestation in 6/11 (55%) cases. One @entity0 presented with a skin-limited @entity2 . Furthermore, 7/12 (58%) @entity0 presented with lesions on the leg. The @entity2 were highly proliferative with blastoid cytology in 12/14 (86%) cases. Moreover, the immunophenotype with expression of @entity1 (100%), @entity10 / @entity11 (83%), and IgM (82%) and lack of @entity6 (25%) and @entity7 (0%) closely resembled the features of primary cutaneous diffuse large @entity5 , @entity9 . Solely the expression of @entity8 (100%) and the presence of t(11;14) (100%) allowed a distinction from cases of primary cutaneous diffuse large @entity5 , @entity9 . Only 2 @entity3 cases with skin involvement presented with classical cytology. Interestingly, in these 2 cases skin involvement occurred simultaneously in a lesion of coexisting primary @entity4 . Our data suggest that clinical presentation on the leg and blastoid cytology along with high proliferation and expression of @entity1 , @entity10 / @entity11 , and IgM are typical for @entity3 involving the skin. Lymphomas with these features might be erroneously diagnosed as diffuse large @entity5 , @entity9 , if @entity8 staining is not performed.

title: Skin Involvement of Mantle Cell Lymphoma May Mimic Primary Cutaneous Diffuse Large @entity5 , XXXX .

answer: @entity9


abstract: Introduction @entity6 ( @entity6 ) is a complication of @entity5 ( @entity5 ) characterized by @entity4 , @entity1 , and heaviness, and may result in @entity3 . Elastic compression stockings (ECS) worn daily after @entity5 have been shown to reduce the incidence and severity of @entity6 . The aim of our study was to investigate practices and perceptions of physicians regarding adjunct therapies to anticoagulation in @entity0 diagnosed with lower extremity @entity5 . METHODS: A national online survey was conducted of Canadian emergency medicine staff physicians and residents (n=471) to investigate their attitudes toward the prescription of ECS post-diagnosis of @entity5 . A paper survey of @entity0 in a @entity2 clinic (n=58) was also administered to better understand the @entity0 experiences with ECS. RESULTS: The majority of staff physician (62%) and resident (69%) respondents were unsure of whether ECS were effective in preventing @entity6 and managing venous symptoms. Only 6% of staff physicians and 7% of residents routinely prescribed ECS for above-knee DVTs. More than 78% of respondents were unsure about the optimal timing of initiation of ECS and duration of therapy. Although all @entity0 noted symptomatic relief with ECS, only 50% were prescribed stockings by an emergency or family doctor, and 69% of those @entity0 wore the stockings on a daily basis. Staff physicians most frequently identified poor fit as the reason for lack of @entity0 compliance, whereas @entity0 most frequently cited cost. CONCLUSIONS: Our findings suggest that there is variability in practice among Canadian emergency medicine physicians and trainees and a need for widespread education regarding the latest evidence of the benefit of ECS after @entity5 .

title: Rates of elastic compression stockings prescription following the diagnosis of XXXX among Canadian emergency physicians and trainees.

answer: @entity5