abstract: The influence of high density lipoproteins (HDL) on luteinizing hormone-stimulated @entity1 ovarian theca/interstitial cell steroidogenesis was studied. Without HDL the cells produced primarily @entity5 from @entity4 precursors. In the presence of @entity1 or @entity0 HDL @entity2 output increased 3-5-fold, but the type of @entity2 produced was dependent on the source of the HDL. @entity0 HDL nonselectively amplified luteinizing hormone-stimulated @entity2 production, whereas @entity1 HDL promoted progestin production without a concomitant increase in @entity3 output. Comparisons of the activities of apoprotein E-rich HDL (e.g. HDL from intact mature @entity1 ) with apoprotein E-poor HDL (e.g. @entity0 HDL or @entity1 HDL from hypophysectomized immature @entity1 ) suggested that apoprotein E was responsible for the inhibition of @entity3 production. Furthermore, the inhibitory activity of @entity1 HDL was abolished by depleting apoprotein E-containing lipoproteins with heparin affinity chromatography. Direct evidence that apoprotein E was the inhibitory constituent of @entity1 HDL was obtained by showing that isolated lipid-free @entity1 apoprotein E inhibited @entity3 production, whereas isolated @entity1 apoproteins A-I and A-IV did not. The possible paracrine function of apoprotein E in ovarian follicular maturation of the ovary is discussed.

title: Apoprotein E-rich high density lipoproteins inhibit ovarian XXXX synthesis.

answer: @entity3


abstract: 1. In helically cut strips of aorta from @entity3 -treated @entity0 , cumulative concentrations (30 microM, 0.3 mM and 3 mM) of @entity6 progressively reduced the basal tone of the preparations and relaxed the smooth muscle contracted by 1 microM @entity2 or by 20 mM K+. 2. The relaxing effect was completely suppressed by tissue pretreatment with @entity1 deaminase (1 U ml-1). 3. Relaxation induced by @entity6 was not affected by 50 microM @entity4 or by 0.1 mM @entity7 and was potentiated by 5 microM @entity5 . 4. Like @entity6 , exogenous @entity1 reduced the basal tone of the @entity0 aorta strips and relaxed the preparations contracted by 1 microM @entity2 or by 20 mM k+ in a concentration-dependent manner. 5. The relaxing activity of exogenous @entity1 was not affected by 50 microM @entity4 , was potentiated by 5 microM @entity5 and was partially antagonized by 0.1 mM @entity7 . 6. These results indicate the involvement of endogenous @entity1 in the relaxing effect of @entity6 on @entity0 aorta strips, but the specific mechanism of @entity6 - @entity1 interaction remains to be elucidated.

title: The response of isolated @entity0 aorta to XXXX .

answer: @entity6


abstract: 1. In helically cut strips of aorta from @entity3 -treated @entity0 , cumulative concentrations (30 microM, 0.3 mM and 3 mM) of @entity6 progressively reduced the basal tone of the preparations and relaxed the smooth muscle contracted by 1 microM @entity2 or by 20 mM K+. 2. The relaxing effect was completely suppressed by tissue pretreatment with @entity1 deaminase (1 U ml-1). 3. Relaxation induced by @entity6 was not affected by 50 microM @entity4 or by 0.1 mM @entity7 and was potentiated by 5 microM @entity5 . 4. Like @entity6 , exogenous @entity1 reduced the basal tone of the @entity0 aorta strips and relaxed the preparations contracted by 1 microM @entity2 or by 20 mM k+ in a concentration-dependent manner. 5. The relaxing activity of exogenous @entity1 was not affected by 50 microM @entity4 , was potentiated by 5 microM @entity5 and was partially antagonized by 0.1 mM @entity7 . 6. These results indicate the involvement of endogenous @entity1 in the relaxing effect of @entity6 on @entity0 aorta strips, but the specific mechanism of @entity6 - @entity1 interaction remains to be elucidated.

title: The response of isolated XXXX aorta to @entity6 .

answer: @entity0


abstract: Thirty-five @entity0 who had @entity1 were followed for three to twenty-two years. Four categories of involvement of the hip were seen. In the first group, thirteen @entity0 had mild disability and slight radiographic changes. In six of those @entity0 the disease was in remission at the time of writing, and the @entity0 were asymptomatic. In the second group, two @entity0 had @entity2 that correlated with the activity of the disease. In the third group, fourteen @entity0 had progressive disability and radiographic changes. Fifty-five of the fifty-nine procedures that were performed on the hip and knee in this series were done on those fourteen @entity0 . In the fourth group, six @entity0 had dramatic clinical and radiographic findings but, at the time of the latest follow-up, had little functional disability. In all six of these @entity0 , the disease was in remission. In the @entity0 in this study, protrusio acetabuli was more cephalad than has been found in adults who have @entity1 . All of the @entity0 had psychosocial problems, but they responded well to counseling. These problems influenced the timing of the surgical treatment.

title: Involvement of the hip in XXXX . A longitudinal study.

answer: @entity1


abstract: Focal @entity10 in the @entity0 was induced by occlusion of the left middle cerebral artery. The temporal evolution of regional energy metabolism was studied over the 14 days consequent to the induction of @entity1 in the frontal, cingulate, parietal, and occipital cortices as well as in the striatum. Regional concentrations of @entity5 ( @entity5 ), @entity8 , and @entity6 and, in addition, @entity4 and the cerebral/plasma @entity4 ratio (C/P) were measured in the hemispheres both ipsilateral and contralateral to the occlusion. Two hours after @entity9 , the biochemical changes were severe in the striatum and moderate in cortical regions. Later on (at 24 and 48 h), an overall aggravated metabolic status was noted while @entity6 declined and @entity4 markedly increased. These latter biochemical changes likely indicate a marked inhibition of the rate of @entity4 utilization. At 48 h, the energy reserves ( @entity5 , @entity8 ) of parietal cortex no longer equaled those of other cortical regions, but abruptly fell to the levels found in the striatum without any increase in @entity6 level. Finally, at 7 and 14 days, the levels of the various metabolites in most cortical regions returned toward control values, although signs of a @entity3 @entity4 metabolism remained. However, in both striatum and parietal cortex, @entity5 and @entity8 concentrations, although higher than those observed at 48 h, remained significantly decreased. Our present biochemical study permits the classification of these selected brain regions into three categories. First there are those that are outside the area of @entity7 : the frontal, cingulate, and occipital cortices. These regions show little temporal evolution of brain energy metabolism but, notwithstanding, they are regions in which @entity4 use would appear to be greatly @entity3 . Second is a region considered to be the focus of @entity7 : the striatum. The caudate-putamen is a region with early and profound @entity2 with no final restitution. Last is the region of metabolic penumbra--the parietal cortex, in which there is a time-related exacerbation of the consequences of middle @entity9 in the @entity0 .

title: Temporal evolution of regional energy metabolism following focal XXXX in the @entity0 .

answer: @entity10


abstract: Focal @entity10 in the @entity0 was induced by occlusion of the left middle cerebral artery. The temporal evolution of regional energy metabolism was studied over the 14 days consequent to the induction of @entity1 in the frontal, cingulate, parietal, and occipital cortices as well as in the striatum. Regional concentrations of @entity5 ( @entity5 ), @entity8 , and @entity6 and, in addition, @entity4 and the cerebral/plasma @entity4 ratio (C/P) were measured in the hemispheres both ipsilateral and contralateral to the occlusion. Two hours after @entity9 , the biochemical changes were severe in the striatum and moderate in cortical regions. Later on (at 24 and 48 h), an overall aggravated metabolic status was noted while @entity6 declined and @entity4 markedly increased. These latter biochemical changes likely indicate a marked inhibition of the rate of @entity4 utilization. At 48 h, the energy reserves ( @entity5 , @entity8 ) of parietal cortex no longer equaled those of other cortical regions, but abruptly fell to the levels found in the striatum without any increase in @entity6 level. Finally, at 7 and 14 days, the levels of the various metabolites in most cortical regions returned toward control values, although signs of a @entity3 @entity4 metabolism remained. However, in both striatum and parietal cortex, @entity5 and @entity8 concentrations, although higher than those observed at 48 h, remained significantly decreased. Our present biochemical study permits the classification of these selected brain regions into three categories. First there are those that are outside the area of @entity7 : the frontal, cingulate, and occipital cortices. These regions show little temporal evolution of brain energy metabolism but, notwithstanding, they are regions in which @entity4 use would appear to be greatly @entity3 . Second is a region considered to be the focus of @entity7 : the striatum. The caudate-putamen is a region with early and profound @entity2 with no final restitution. Last is the region of metabolic penumbra--the parietal cortex, in which there is a time-related exacerbation of the consequences of middle @entity9 in the @entity0 .

title: Temporal evolution of regional energy metabolism following focal @entity10 in the XXXX .

answer: @entity0


abstract: The 5-year survival rate for @entity0 with @entity3 ( @entity3 ) who undergo complete surgical resection is only 40-69%, depending on the stage. It is well known that distant metastatic disease is the dominant site of recurrence in such @entity0 and this observation served as the basis for trials of postoperative systemic therapy. The earliest trials of adjuvant chemotherapy, which consisted of single alkylating agents, did not achieve this goal or, even worse, showed a detrimental effect on survival. The introduction of more active drugs, such as @entity2 and vinca alkaloids, made it possible to obtain more promising results in terms of delayed recurrence of the disease. A recent meta-analysis of all randomized trials with accrual from January 1965 to December 1991 showed that the absolute risk of @entity1 was reduced by 3% at 2 years and by 5% at 5 years for @entity0 who were treated with postoperative @entity2 -containing regimens compared with @entity0 who were treated with surgery alone. Although the results of this meta-analysis suggest that postoperative @entity2 chemotherapy regimens may result in a slight survival improvement, adjuvant chemotherapy in @entity3 cannot be considered a standard therapy, and it is important that large, carefully conducted, randomized trials are performed in this group of @entity0 . Four such randomized trials are being conducted in Europe. One of them, the @entity4 trial, recently completed its accrual with 1200 @entity0 . The IALT, ANITA, and MRC trials are still ongoing. The results of such trials are eagerly awaited and it is hoped that, once the value of postoperative chemotherapy is well ascertained, future developments can further improve results of combined treatment. In such direction, the recently reported results of PORT meta-analysis evaluating the role of radiation therapy are of great contribution in selecting a suitable population for future studies. In fact, only @entity0 with pN2 disease seem to have a beneficial effect in terms of survival, especially if they have a good performance status, while radiotherapy is not justified in N0-1 @entity0 . The optimal integration of chemotherapy and radiation therapy when both therapies are indicated represents another goal for future research.

title: Consensus conference on medical treatment of XXXX : adjuvant treatment.

answer: @entity3


abstract: The clinical relevance of a new antimitochondrial antibody, anti-M9, reacting with an outer membrane-associated antigen on liver mitochondria is described. Sera from 22 anti-M2-negative @entity0 with histologically proven @entity2 ( @entity2 ) who had been followed for 5-15 years were tested for anti-M9 in the ELISA using a purified M9-fraction. 18 (82%) were anti-M9-positive, and 17 of them (94%) were in stage I/II. None of the 17 anti-M9-positive/anti-M2-negative @entity0 with early @entity2 progressed to stage III/IV during the observation period of 5-15 years, and in all instances anti-M9 remained of the IgM-type. In one anti-M9-positive patient anti-M2 of the IgM type appeared 2 years after the first demonstration of anti-M9. Among 156 patients with anti-M2-positive @entity2 , 58 (37%) had anti-M9, and 39 of them (67%) were in stage I/II. 19 of these 39 stage I/II @entity0 (49%) had anti-M9 exclusively of the IgM-type in contrast to none of the 19 stage III/IV @entity0 . Using the purified M9-fraction in ELISA and Western blotting, anti-M9 antibodies were confined only to @entity0 with @entity2 or overlap syndromes between @entity2 and @entity3 (10% of 133 @entity0 ) and were not found in @entity0 with other hepatic and @entity1 . We conclude that the determination of anti-M9 may be helpful for the diagnosis of early and asymptomatic @entity2 . From follow-up studies of anti-M9-positive but anti-M2-negative @entity0 it emerges that this antibody type may be associated with a benign course of @entity2 .

title: The antimitochondrial antibody anti-M9. A marker for the diagnosis of early XXXX .

answer: @entity2


abstract: One hundred and fifty-two cases with @entity2 were treated in our clinic between 1973 and 1985. The average age was 55.89 years, and the age range was from 29 to 76 years. Thirty-six cases (23.7%) were nulligravidas and 42 cases (27.6%) were nulliparas. One hundred and ten cases (72.4%) were postmenopausal and the average age at menopause was 49.1 years. The most frequent chief complaint was @entity1 which was noted in 128 cases (84.2%). The result of a cytologic examination of the uterine cervix was positive in 50.7% and suspicious in 16.9% but results for the endometrium were positive in 63% and suspicious in 21.9%. The cases in this study were classified into 88 cases (57.9%) of T1a, 36 cases (23.7%) of T1b, 12 cases (7.9%) of T2, 3 cases (2.0%) of T3 and 1 case (0.7%) of T4. As to the postoperative diagnosis, there were classified into 86 cases (56.6%) of pT1a, 30 cases (19.7%) of pT1b, 19 cases (12.5%) of pT2, 10 cases (6.6%) of @entity3 and 5 cases (3.3%) of pT4. Histopathologically almost all 140 cases (91.41%) were of @entity0 and classified into 88 cases (57.9%) of G1, 39 cases (25.7%) of G2 and 13 cases (8.6%) of G3. The cumulative survival rates after Kaplan-Meier were 95% in pT1a cases, 75.6% in pT1b cases, 67.3% in pT2 cases, 42.2% in @entity3 cases and 0% in pT4 cases.

title: [Clinical studies on XXXX ].

answer: @entity2


abstract: OBJECTIVE: To determine if performing an endocervical curettage (ECC) at the time of conization is a useful diagnostic tool for predicting residual cervical @entity2 ( @entity2 ) among @entity0 who might wish to preserve their fertility. METHODS: All @entity0 diagnosed with @entity2 from 1995 to 2000 at four institutions were identified. Data were retrospectively extracted from clinical records. @entity0 included in the statistical analysis were (1) younger than 40 years, (2) had an ECC performed at the time of the initial cone biopsy, (3) had a clearly demarcated surgical margin pathologically, and (4) underwent a second surgical procedure. RESULTS: Twenty-nine (24%) of 123 @entity2 @entity0 met criteria for inclusion. The median age was 33 years (range, 17 to 39) and 13 (46%) were nulliparous. Initial surgery was a cold-knife conization (n = 17) or loop electrosurgical excision procedure (n = 12). Twelve (41%) ECCs and 15 (52%) cone margins were histologically positive. Sixteen @entity0 underwent a repeat conization; 13 underwent hysterectomy. Thirteen (45%) @entity0 had residual @entity2 at the time of their second surgical procedure. ECC had a superior positive predictive value (100% vs 47%; P < 0.01) and negative predictive value (94% vs 57%; P = 0.01) compared to cone margin in predicting residual @entity2 . None of the @entity0 undergoing fertility-sparing surgery developed recurrent @entity2 or @entity1 . CONCLUSION: ECC performed at the time of conization may be a useful tool for predicting residual @entity2 in @entity0 considering fertility preservation.

title: Endocervical curettage at conization to predict residual cervical XXXX .

answer: @entity2


abstract: In this study, changes of protein binding of nine drugs were evaluated. In addition, @entity7 and @entity10 , the two drugs with the most substantial and progressive decrease in protein binding, were further studied by high performance liquid chromatography (HPLC)-fractions of ultrafiltrate of normal and uremic serum, in an attempt to identify substances causing drug protein binding inhibition. There was a marked decline of the protein binding of @entity7 , @entity10 and @entity6 (dialyzed @entity0 vs. normals: -20.1, -16.0 and -15.1%, respectively). There was a rise in the protein binding of @entity3 , @entity12 and @entity5 . The changes observed for @entity11 , @entity9 and @entity8 were less marked. For @entity10 , @entity7 , @entity6 and @entity11 , protein binding was inversely correlated to the serum @entity2 (r = 0.87, 0.80, 0.79 and 0.67, P less than 0.001), and a less pronounced but still significant positive correlation was found for @entity5 (r = 0.46, P less than 0.01). Ultrafiltrate, obtained during a hemofiltration session, inhibited protein binding of @entity7 and @entity10 in a dose dependent way. After separation of this ultrafiltrate by HPLC, it appeared that for both @entity7 and @entity10 at least a part of this inhibitory activity corresponded to the elution zone of @entity13 . For @entity7 two other inhibitory zones were further recognized: one corresponding to the elution zone of @entity4 and one in which the responsible substance remained unidentified. @entity13 in solution inhibited protein binding of @entity7 and @entity10 in a dose dependent way. In conclusion, protein binding of several drugs currently used in @entity1 is affected in parallel with renal function, which might affect the therapeutic effectiveness of the drugs.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Drug protein binding in XXXX : evaluation of nine drugs.

answer: @entity1


abstract: BACKGROUND: @entity5 ( @entity5 ) is a heterogeneous, lethal combination of @entity4 characterized by severe underdevelopment of left @entity2 , resulting in a univentricular circulation. The genetic determinants of this disorder are largely unknown. Evidence of copy number variants (CNVs) contributing to the genetic etiology of @entity5 and other @entity6 has been mounting. However, the functional effects of such CNVs have not been examined, particularly in cases where the variant of interest is found in only a single @entity0 . METHODS AND RESULTS: Whole-genome SNP microarrays were employed to detect CNVs in two @entity0 cohorts (N = 70 total) predominantly diagnosed with some form of nonsyndromic @entity5 . We discovered 16 rare or private variants adjacent to or overlapping 20 genes associated with cardiovascular or premature lethality phenotypes in @entity1 knockout models. We evaluated the impact of selected variants on the expression of nine of these genes through quantitative PCR on cDNA derived from @entity0 heart tissue. Four genes displayed significantly altered expression in @entity0 with an overlapping or proximal @entity3 verses @entity0 without such CNVs. CONCLUSION: Rare and private genomic imbalances perturb transcription of genes that potentially affect cardiogenesis in a subset of nonsyndromic @entity5 @entity0 . Clin Trans Sci 2015; Volume #: 1-8.

title: Transcriptional Impact of Rare and Private Copy Number Variants in XXXX .

answer: @entity5


abstract: This paper reviews historical, anthropological and contemporary survey data concerning gender differences in @entity1 use in Africa, Asia, the Pacific, and Latin America. In many cultural groups in these regions, @entity1 use has been substantially more common among @entity0 than among @entity0 . In some groups, @entity1 use has been about equally common for both sexes. No evidence was found of any group in which @entity1 use has been substantially more common among @entity0 . The widespread pattern of greater @entity1 use by @entity0 appears to be linked to general features of sex roles. For example, @entity0 have often had greater social power than @entity0 , and this has been expressed in greater restrictions on @entity0 's behavior, including social prohibitions against @entity0 's smoking. These social prohibitions against @entity0 's smoking have strongly inhibited @entity0 's tobacco use and thus have been a major cause of gender differences in @entity1 use. Gender differences in @entity1 use have varied in magnitude, depending on the type of @entity1 use and the particular cultural group, age group and historical period considered. Causes of the variation in gender differences in @entity1 use include variation in @entity0 's status and variation in the social significance and benefits attributed to particular types of @entity1 use in different cultures. Contact with Western cultures appears to have increased or decreased gender differences in smoking, depending on the specific circumstances. The patterns of gender differences in @entity1 use in non-Western societies are similar in many ways to the patterns observed in Western societies, but there are several important differences.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Gender differences in XXXX use in Africa, Asia, the Pacific, and Latin America.

answer: @entity1


abstract: BACKGROUND: There are limited data available describing relatively contemporary trends in 30-day rehospitalizations among @entity0 who survive hospitalization after an @entity1 ( @entity1 ) in the community setting. We examined decade-long (2001-2011) trends in, and factors associated with, 30-day rehospitalizations in @entity0 discharged from 3 central Massachusetts hospitals after @entity1 . METHODS AND RESULTS: Residents of the Worcester, MA, metropolitan area discharged after @entity1 from 3 central Massachusetts hospitals on a biennial basis between 2001 and 2011 comprised the study population (N=4810). Logistic regression analyses were used to examine the association between selected factors and 30-day rehospitalizations. The average age of this population was 69 years, 42% were @entity0 , and 92% were white. During the years under study, 18.5% of @entity0 were rehospitalized within 30 days after hospital discharge. Crude 30-day rehospitalization rates decreased from 20.5% in 2001-2003 to 15.8% in 2009-2011. After adjusting for several @entity0 characteristics, there was a reduced odds of being rehospitalized in 2009-2011 (odds ratio 0.74, 95% CI 0.61-0.91) compared with 2001-2003; this trend was slightly attenuated after further adjustment for hospital treatment practices. Female sex, having previously diagnosed @entity2 and @entity3 , and the development of in-hospital @entity4 and @entity2 were associated with an increased odds of being rehospitalized. CONCLUSIONS: While the likelihood of subsequent short-term rehospitalizations remained frequent, we observed an encouraging decline during the most recent years under study. Several high-risk groups were identified for purposes of heightened surveillance and intervention efforts to reduce the likelihood of being readmitted.

title: Decade-Long Trends in 30-Day Rehospitalization Rates After Acute XXXX .

answer: @entity1


abstract: Six @entity0 with @entity5 of the internal maxillary artery were treated with transarterial embolization. The @entity0 ranged in age from 19 to 47 years, with a mean of 26.5 years. Each had a lifelong history of symptoms suggestive of a congenital origin of symptoms. There was no history of @entity2 . The most common initial symptoms were bruit (83%), pulsatile mass (67%), and @entity3 (50%). In one @entity0 prior surgical ligation of the external carotid artery had been attempted, but it led to aggravation of @entity1 . All @entity0 were treated with placement of a detachable balloon at the @entity4 site. In one @entity0 the balloon migrated through the @entity4 , which was retreated with coils. Complete obliteration of the @entity4 was achieved in all @entity0 . The follow-up ranged from 2 months to 10 years, with a mean of 5.2 years. @entity5 of the internal maxillary artery are rare and can be treated effectively with transvascular techniques.

title: Arteriovenous XXXX of the internal maxillary artery: treatment with transarterial embolization.

answer: @entity4


abstract: BACKGROUND: @entity2 ( @entity2 ) is defined as the new onset or recurrence of gradual or rapidly worsening signs and symptoms of @entity2 , requiring urgent or emergent therapy. OBJECTIVES: This study attempts to assess the association of liver function tests (LFT) and @entity1 level with in hospital outcome and echocardiography parameters, in @entity0 with acute decompensated @entity2 . @entity0 AND METHODS: A total of 100 @entity0 (aged 16 - 90 years, 60% @entity0 ) admitted with @entity2 were enrolled. LFTs and @entity1 levels were assessed on first day and before discharge, and @entity0 were followed for 3 months. RESULTS: In-hospital outcomes were considered. Mean @entity3 ( @entity3 ) was 35% (20 - 45%). Mean @entity1 level was 8.4 mg/dL, significantly higher than chronic HF and normal groups (P < 0.02). Elevated liver enzymes were seen in 52% @entity0 , mostly (87%) in transaminases. Liver enzymes were decreased in 85% @entity0 before discharge. LFT and @entity1 levels were inversely and significantly correlated with @entity3 on echocardiography (P = 0.02), but not with diastolic parameters. Although there was no significant correlation between @entity1 level and in-hospital mortality, risk of intubation and rehospitalization in 3 months, enzyme levels increased in these groups. Increased @entity4 transaminase ( @entity5 level) was associated with inotrope infusion in @entity2 @entity0 (42 vs. 82 mg/dL, P = 0.03). CONCLUSIONS: Abnormal transaminases and @entity1 levels are seen in @entity2 @entity0 . Increased @entity5 levels may be a predictor of the need for inotrope during hospital course in these @entity0 .

title: Liver Enzymes and @entity1 in Acute XXXX .

answer: @entity2


abstract: BACKGROUND: @entity2 ( @entity2 ) is defined as the new onset or recurrence of gradual or rapidly worsening signs and symptoms of @entity2 , requiring urgent or emergent therapy. OBJECTIVES: This study attempts to assess the association of liver function tests (LFT) and @entity1 level with in hospital outcome and echocardiography parameters, in @entity0 with acute decompensated @entity2 . @entity0 AND METHODS: A total of 100 @entity0 (aged 16 - 90 years, 60% @entity0 ) admitted with @entity2 were enrolled. LFTs and @entity1 levels were assessed on first day and before discharge, and @entity0 were followed for 3 months. RESULTS: In-hospital outcomes were considered. Mean @entity3 ( @entity3 ) was 35% (20 - 45%). Mean @entity1 level was 8.4 mg/dL, significantly higher than chronic HF and normal groups (P < 0.02). Elevated liver enzymes were seen in 52% @entity0 , mostly (87%) in transaminases. Liver enzymes were decreased in 85% @entity0 before discharge. LFT and @entity1 levels were inversely and significantly correlated with @entity3 on echocardiography (P = 0.02), but not with diastolic parameters. Although there was no significant correlation between @entity1 level and in-hospital mortality, risk of intubation and rehospitalization in 3 months, enzyme levels increased in these groups. Increased @entity4 transaminase ( @entity5 level) was associated with inotrope infusion in @entity2 @entity0 (42 vs. 82 mg/dL, P = 0.03). CONCLUSIONS: Abnormal transaminases and @entity1 levels are seen in @entity2 @entity0 . Increased @entity5 levels may be a predictor of the need for inotrope during hospital course in these @entity0 .

title: Liver Enzymes and XXXX in Acute @entity2 .

answer: @entity1


abstract: BACKGROUND: Endoscopic removal of duodenal and @entity7 is currently considered to be the standard of care for prevention of @entity2 . The use of cautery carries a risk of delayed @entity4 , @entity8 , and perforation. We examined the safety and feasibility of removing @entity6 >= 1cm using a piecemeal cold snare polypectomy technique. @entity0 : The study included 15 @entity0 with @entity5 >= 1cm and 15 @entity0 with @entity6 >= 1cm. MAIN OUTCOME MEASUREMENTS: Bleeding, perforation, @entity3 , or hospitalization occurring within 2 weeks of polypectomy. RESULTS: Between 24 August 2011 and 29 April 2013, 15 @entity0 had @entity5 >= 1cm. Mean @entity0 age was 64 years and 9/15 @entity0 were male. The mean polyp size was 24mm (10-60mm). All @entity5 were removed with a cold snare and some required cold biopsy forceps. One @entity0 required hospitalization for gastrointestinal @entity1 7 days post-polypectomy; this @entity0 was using Coumadin. Between 27 February 2012 and 30 May 2013, 15 @entity0 underwent resection of a >= 1cm @entity6 .Mean @entity0 age was 68 years and 9/15 were male. The mean polyp size was 20mm (10-45mm). All @entity5 were primarily removed with a cold snare. None of the @entity0 required hemostatic clips for control of immediate @entity4 . One @entity0 presented to the emergency department with @entity3 1 day after initial endoscopy. CT scan showed no abnormalities and the @entity0 was discharged. CONCLUSIONS: Cold snare polypectomy for large duodenal and @entity6 is technically feasible and may have a favorable safety profile compared to standard electrocautery-based endoscopic resection. Comparative trials are required to determine the relative safety and efficacy of cold snare techniques for complete and durable resection of large @entity5 compared to standard hot snare methods.

title: Cold snare piecemeal resection of XXXX >= 1cm.

answer: @entity6


abstract: Futuna is a small Polynesian island in the South Pacific with a population of 3,612 in 2013. The first @entity0 @entity3 case was confirmed in 1997. Active surveillance started in 2004. Cases were confirmed by PCR or real time PCR, or by serology using MAT or a combination of IgM-ELISA and MAT. A retrospective analysis of surveillance data shows that the disease was endemic with a mean annual incidence of 844 cases per 100,000 over an 11-year period from 2004 to 2014. An epidemic peak as high as 1,945 cases per 100,000 occurred in 2008. Serogroup Australis was predominant until 2007, Icterohaemorrhagiae was dominant afterwards. Cluster analysis revealed different hot spots over time. Lifestyle habits, such as walking barefoot in irrigated @entity4 fields or @entity2 pens probably contributed to contamination from the @entity2 and rodent reservoirs to @entity0 . Severe forms were rare, and the case fatality rate was 0.5%. The medical community and general population were aware of @entity3 and rapid treatment with @entity1 was the main treatment, probably contributing to this low fatality rate.

title: An Unprecedented High Incidence of XXXX in Futuna, South Pacific, 2004 - 2014, Evidenced by Retrospective Analysis of Surveillance Data.

answer: @entity3


abstract: OBJECTIVES: @entity1 can be treated by radical prostatectomy and provoke @entity2 as secondary effect. Our aim is to calculate the prevalence of @entity2 , characteristics of leakage and influential factors, through a historical series. METHODS: We perform a descriptive, observational and retrospective study of 1310 @entity0 who received treatment for PCa between 1989 and 2011. Prevalence was obtained after 12 months of recovery and using ICS definition. To complete ICIQ-SF and number of pads/day used we perform a cross-sectional study. The series is studied globally and divided in two groups according to oncologic characteristics. We perform a descriptive, comparative and predictive analysis. RESULTS: Prevalence of the series was 23.5%, 296 @entity0 . 279 incontinent @entity0 completed ICIQ-SF with a mean score of 11.1  4.03. 16.4% of the @entity0 use 1 pad/day or none, 69% (11.4% of the total) use compress and 22% diapers. 8% of the total use more than 1 pad/day. Clinico-pathological factors divide series in two groups: 1989-1999 with a prevalence of 24.6% and 2000-2011 with 22.8%. Multivariate analysis shows influential factors: age (65 years) (OR:1.65, p=0.013) and prostate volume (50cc) (OR:1.49, p=0.029). CONCLUSIONS: @entity2 is a disease with some prevalence that varies depending on definition. The most common situation was to leak several times a day (42.2%), a small amount (59.1%), using compress (69%) most of incontinents with a mild (0-7: 88.2%) impact on quality of life. Predictive factors were age (65 years) and prostate volume (50cc). The historical changes does not influence over prevalence.

title: Assessment and prevalence of XXXX after radical prostatectomy: Analysis of a historical series.

answer: @entity2


abstract: Conjugated @entity8 (CLA) is a mixture of positional (e.g. 7,9; 9,11; 10,12; 11,13) and geometric (cis or trans) isomers of @entity10 . This compound was first shown to prevent mammary carcinogenesis in @entity0 models. Later investigations uncovered a number of additional health benefits, including decreasing @entity3 and @entity2 while enhancing immune function. The mechanisms of action underlying these biological properties are not clearly understood. The aim of this review is to highlight recent advances in CLA research related to experimental @entity1 . In addition, two possible mechanisms of action (i.e. endoplasmic and nuclear) were discussed in detail in the context of enteric inflammatory disorders. Conjugated @entity8 was first implicated in down-regulating the generation of inducible @entity6 (i.e. @entity4 and LTB(4)) involved in early micro-inflammatory events (endoplasmic). More recently, CLA has been shown to modulate the expression of genes regulated by peroxisome proliferator-activated receptors (PPARs; nuclear). In @entity5 , prolonged dietary CLA treatment stimulated the expression of @entity9 in the muscle. Thus, evidence supporting both mechanistic theories of CLA acting through eicosanoid synthesis and @entity7 activity is available. The further understanding of the anti-inflammatory mechanisms of action of CLA may yield novel nutritional therapies for enteric @entity2 .

title: Colonic anti-inflammatory mechanisms of conjugated XXXX .

answer: @entity8


abstract: Short-latency somatosensory evoked potential (SEP) was serially monitored in head-injured @entity0 and its clinical significance was evaluated in relation to auditory brain stem response (ABR), prognosis and other parameters such as @entity3 ( @entity3 ). SEP, ABR, and @entity3 were monitored serially and automatically in 16 @entity0 with @entity4 . Glasgow @entity5 Scale (GCS) score was equal to or less than 8 in 14 cases. High dose barbiturate therapy was performed in 7 cases and @entity6 was removed operatively in 14 cases. SEP was recorded from C3'or C4'-Fz leads on the lesion side following stimulation of the contralateral median nerve, and the difference between the two potentials (N20, N13) defined as central conduction time (CCT) was followed at a basic time interval of 10-20 min. The @entity0 were divided into 3 groups according to N20 finding and the prognosis of each group was analyzed. The final outcome (assessed 6 months after injury) was graded according to Glasgow Outcome Scale as follows: good (good recovery, moderate disability), poor (severe disability, persistent @entity1 ), @entity2 ( @entity2 ). Three @entity0 with no CCT change showed good recovery (table, 11). Out of 7 @entity0 with no N20 on admission, 5 died due to severely increased @entity3 and the prognosis for the other 2 cases was poor. The last group consisted of 6 @entity0 in whom CCT varied during hospitalization. In 3 out of these 6 cases N20 finally disappeared due to increased @entity3 and they died in the acute stage.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Clinical significance of serial monitoring of short-latency somatosensory evoked potential in XXXX with special reference to intracranial hypertension].

answer: @entity4


abstract: @entity2 ( @entity3 ) is an effective symptomatic treatment of @entity1 ( @entity1 ), but the mechanisms of its therapeutic action have not been fully elucidated. To address this issue, we assessed the effects of discontinuation of chronic @entity3 treatment on regional cerebral blood flow (rCBF) in @entity1 @entity0 . METHODS: Twenty-two prepubescent @entity0 with @entity1 (age range, 8.2-11.5 y) and 7 healthy volunteers were studied with SPECT on and off @entity3 . Their rCBF data were automatically normalized to whole-brain counts and coregistered with standard anatomic space. rCBF changes were evaluated with statistical parametric mapping based on voxel-by-voxel ANOVA. RESULTS: When the subjects were not taking @entity3 , rCBF was higher in the motor, premotor, and the anterior cingulate cortices (Brodmann's areas 4, 6, and 32). CONCLUSION: Brief discontinuation of @entity3 treatment is associated with increased motor and anterior cingulate cortical activity. Our findings suggest that @entity3 treatment modulates motor and anterior cingulate cortical activity directly or indirectly. Alternatively, our findings may be related to @entity3 withdrawal. These data provide novel information on the potential mechanisms of the therapeutic action of @entity3 . Furthermore, they are clinically relevant to the commonly occurring brief interruptions in @entity3 treatment.

title: Effects of @entity2 discontinuation on cerebral blood flow in prepubescent @entity0 with XXXX .

answer: @entity1


abstract: @entity2 ( @entity3 ) is an effective symptomatic treatment of @entity1 ( @entity1 ), but the mechanisms of its therapeutic action have not been fully elucidated. To address this issue, we assessed the effects of discontinuation of chronic @entity3 treatment on regional cerebral blood flow (rCBF) in @entity1 @entity0 . METHODS: Twenty-two prepubescent @entity0 with @entity1 (age range, 8.2-11.5 y) and 7 healthy volunteers were studied with SPECT on and off @entity3 . Their rCBF data were automatically normalized to whole-brain counts and coregistered with standard anatomic space. rCBF changes were evaluated with statistical parametric mapping based on voxel-by-voxel ANOVA. RESULTS: When the subjects were not taking @entity3 , rCBF was higher in the motor, premotor, and the anterior cingulate cortices (Brodmann's areas 4, 6, and 32). CONCLUSION: Brief discontinuation of @entity3 treatment is associated with increased motor and anterior cingulate cortical activity. Our findings suggest that @entity3 treatment modulates motor and anterior cingulate cortical activity directly or indirectly. Alternatively, our findings may be related to @entity3 withdrawal. These data provide novel information on the potential mechanisms of the therapeutic action of @entity3 . Furthermore, they are clinically relevant to the commonly occurring brief interruptions in @entity3 treatment.

title: Effects of XXXX discontinuation on cerebral blood flow in prepubescent @entity0 with @entity1 .

answer: @entity2


abstract: @entity2 ( @entity3 ) is an effective symptomatic treatment of @entity1 ( @entity1 ), but the mechanisms of its therapeutic action have not been fully elucidated. To address this issue, we assessed the effects of discontinuation of chronic @entity3 treatment on regional cerebral blood flow (rCBF) in @entity1 @entity0 . METHODS: Twenty-two prepubescent @entity0 with @entity1 (age range, 8.2-11.5 y) and 7 healthy volunteers were studied with SPECT on and off @entity3 . Their rCBF data were automatically normalized to whole-brain counts and coregistered with standard anatomic space. rCBF changes were evaluated with statistical parametric mapping based on voxel-by-voxel ANOVA. RESULTS: When the subjects were not taking @entity3 , rCBF was higher in the motor, premotor, and the anterior cingulate cortices (Brodmann's areas 4, 6, and 32). CONCLUSION: Brief discontinuation of @entity3 treatment is associated with increased motor and anterior cingulate cortical activity. Our findings suggest that @entity3 treatment modulates motor and anterior cingulate cortical activity directly or indirectly. Alternatively, our findings may be related to @entity3 withdrawal. These data provide novel information on the potential mechanisms of the therapeutic action of @entity3 . Furthermore, they are clinically relevant to the commonly occurring brief interruptions in @entity3 treatment.

title: Effects of @entity2 discontinuation on cerebral blood flow in prepubescent XXXX with @entity1 .

answer: @entity0


abstract: Accumulation of postprandial @entity3 -rich lipoproteins is generated by assimilation of ingested dietary fat and has been increasingly related to atherogenic risk. Nevertheless, the influence of different kinds of dietary @entity4 on postprandial lipid metabolism is not well established, except for (n-3) polyunsaturated long-chain @entity4 . Our goal was to evaluate the effects of test meals containing a common edible fat source of saturated (butter), monounsaturated (olive oil) or (n-6) polyunsaturated (sunflower oil) @entity4 on postprandial lipid and @entity3 -rich lipoprotein responses. After a 12-h fast, 10 healthy young @entity0 ingested mixed meals containing 0 g (control) or 40 g fat, provided as butter, olive oil or sunflower oil in a random order. Fasting and postmeal blood samples were collected for 7 h. The no-fat test meal did not elicit any change over baseline except for plasma phospholipids, insulin and nonesterified @entity4 . Conversely, the three fat-containing meals elicited bell-shaped postprandial changes (P < 0.05) in serum @entity3 , free and esterified @entity1 , and nonesterified @entity4 . The butter meal induced a lower postprandial rise of @entity3 in serum and chylomicrons (incremental AUC, mmol.h/L: 0.72) than the two unsaturated oils (olive oil: 1.6, sunflower oil: 1.8), which did not differ. Circulating chylomicrons were smaller after the butter meal than after the two vegetable oil meals. The in vitro susceptibility of circulating chylomicrons to hydrolysis by postheparin plasma was higher after sunflower oil than after butter or olive oil. We conclude that butter results in @entity2 and chylomicron accumulation in the circulation of young @entity0 than olive or sunflower oils after consumption of a single mixed meal.

title: Butter differs from olive oil and sunflower oil in its effects on postprandial @entity2 and XXXX -rich lipoproteins after single mixed meals in healthy young @entity0 .

answer: @entity3


abstract: Accumulation of postprandial @entity3 -rich lipoproteins is generated by assimilation of ingested dietary fat and has been increasingly related to atherogenic risk. Nevertheless, the influence of different kinds of dietary @entity4 on postprandial lipid metabolism is not well established, except for (n-3) polyunsaturated long-chain @entity4 . Our goal was to evaluate the effects of test meals containing a common edible fat source of saturated (butter), monounsaturated (olive oil) or (n-6) polyunsaturated (sunflower oil) @entity4 on postprandial lipid and @entity3 -rich lipoprotein responses. After a 12-h fast, 10 healthy young @entity0 ingested mixed meals containing 0 g (control) or 40 g fat, provided as butter, olive oil or sunflower oil in a random order. Fasting and postmeal blood samples were collected for 7 h. The no-fat test meal did not elicit any change over baseline except for plasma phospholipids, insulin and nonesterified @entity4 . Conversely, the three fat-containing meals elicited bell-shaped postprandial changes (P < 0.05) in serum @entity3 , free and esterified @entity1 , and nonesterified @entity4 . The butter meal induced a lower postprandial rise of @entity3 in serum and chylomicrons (incremental AUC, mmol.h/L: 0.72) than the two unsaturated oils (olive oil: 1.6, sunflower oil: 1.8), which did not differ. Circulating chylomicrons were smaller after the butter meal than after the two vegetable oil meals. The in vitro susceptibility of circulating chylomicrons to hydrolysis by postheparin plasma was higher after sunflower oil than after butter or olive oil. We conclude that butter results in @entity2 and chylomicron accumulation in the circulation of young @entity0 than olive or sunflower oils after consumption of a single mixed meal.

title: Butter differs from olive oil and sunflower oil in its effects on postprandial XXXX and @entity3 -rich lipoproteins after single mixed meals in healthy young @entity0 .

answer: @entity2


abstract: Accumulation of postprandial @entity3 -rich lipoproteins is generated by assimilation of ingested dietary fat and has been increasingly related to atherogenic risk. Nevertheless, the influence of different kinds of dietary @entity4 on postprandial lipid metabolism is not well established, except for (n-3) polyunsaturated long-chain @entity4 . Our goal was to evaluate the effects of test meals containing a common edible fat source of saturated (butter), monounsaturated (olive oil) or (n-6) polyunsaturated (sunflower oil) @entity4 on postprandial lipid and @entity3 -rich lipoprotein responses. After a 12-h fast, 10 healthy young @entity0 ingested mixed meals containing 0 g (control) or 40 g fat, provided as butter, olive oil or sunflower oil in a random order. Fasting and postmeal blood samples were collected for 7 h. The no-fat test meal did not elicit any change over baseline except for plasma phospholipids, insulin and nonesterified @entity4 . Conversely, the three fat-containing meals elicited bell-shaped postprandial changes (P < 0.05) in serum @entity3 , free and esterified @entity1 , and nonesterified @entity4 . The butter meal induced a lower postprandial rise of @entity3 in serum and chylomicrons (incremental AUC, mmol.h/L: 0.72) than the two unsaturated oils (olive oil: 1.6, sunflower oil: 1.8), which did not differ. Circulating chylomicrons were smaller after the butter meal than after the two vegetable oil meals. The in vitro susceptibility of circulating chylomicrons to hydrolysis by postheparin plasma was higher after sunflower oil than after butter or olive oil. We conclude that butter results in @entity2 and chylomicron accumulation in the circulation of young @entity0 than olive or sunflower oils after consumption of a single mixed meal.

title: Butter differs from olive oil and sunflower oil in its effects on postprandial @entity2 and @entity3 -rich lipoproteins after single mixed meals in healthy young XXXX .

answer: @entity0


abstract: BACKGROUND AND PURPOSE: @entity11 develops very early after the onset of focal @entity12 and may be a major factor in @entity8 after an acute @entity4 . There have been very limited studies on the usefulness of antiedemic agents as neuroprotective agents in the setting of focal @entity12 . We tested the neuroprotective effects of a new potent nonpeptide vasopressin receptor V(1) antagonist, @entity13 , in a focal @entity3 model in @entity0 . METHODS: Focal @entity2 was induced by embolizing a preformed clot into the middle cerebral artery (MCA). @entity9 volume was measured at 48 hours after the @entity10 . @entity1 , @entity11 , @entity5 activity, and mortality and @entity7 rates were also documented. RESULTS: Treatment with @entity13 (2 mg/kg), initiated immediately after @entity10 , significantly reduced @entity9 volume (P<0.05) measured at 48 hours after the @entity6 . In animals in which the treatment was delayed for 1 hour after @entity10 , @entity9 volume was also reduced significantly (P<0.05). @entity9 volume in the @entity0 that received the drug at 3 or 6 hours after @entity10 was not different from that in the vehicle-treated group. Treatment with @entity13 , when started early after the @entity6 , also reduced @entity1 and @entity11 . Injection of drug at a higher dose (30 mg/kg) also reduced @entity9 volume and improved functional recovery but was not superior to the lower dose (2 mg/kg) when the drug was administrated at 1 hour after @entity10 . CONCLUSIONS: Our data show that the selective vasopressin receptor antagonist @entity13 is a potent neuroprotective agent when used early after onset of @entity6 in an embolic focal @entity2 model in @entity0 . Further studies are needed in @entity3 models to better understand its neuroprotective properties when used alone or in combination with thrombolysis.

title: Effects of nonpeptide V(1) vasopressin receptor antagonist @entity13 on XXXX volume and recovery of function in a focal @entity3 model.

answer: @entity9


abstract: BACKGROUND AND PURPOSE: @entity11 develops very early after the onset of focal @entity12 and may be a major factor in @entity8 after an acute @entity4 . There have been very limited studies on the usefulness of antiedemic agents as neuroprotective agents in the setting of focal @entity12 . We tested the neuroprotective effects of a new potent nonpeptide vasopressin receptor V(1) antagonist, @entity13 , in a focal @entity3 model in @entity0 . METHODS: Focal @entity2 was induced by embolizing a preformed clot into the middle cerebral artery (MCA). @entity9 volume was measured at 48 hours after the @entity10 . @entity1 , @entity11 , @entity5 activity, and mortality and @entity7 rates were also documented. RESULTS: Treatment with @entity13 (2 mg/kg), initiated immediately after @entity10 , significantly reduced @entity9 volume (P<0.05) measured at 48 hours after the @entity6 . In animals in which the treatment was delayed for 1 hour after @entity10 , @entity9 volume was also reduced significantly (P<0.05). @entity9 volume in the @entity0 that received the drug at 3 or 6 hours after @entity10 was not different from that in the vehicle-treated group. Treatment with @entity13 , when started early after the @entity6 , also reduced @entity1 and @entity11 . Injection of drug at a higher dose (30 mg/kg) also reduced @entity9 volume and improved functional recovery but was not superior to the lower dose (2 mg/kg) when the drug was administrated at 1 hour after @entity10 . CONCLUSIONS: Our data show that the selective vasopressin receptor antagonist @entity13 is a potent neuroprotective agent when used early after onset of @entity6 in an embolic focal @entity2 model in @entity0 . Further studies are needed in @entity3 models to better understand its neuroprotective properties when used alone or in combination with thrombolysis.

title: Effects of nonpeptide V(1) vasopressin receptor antagonist @entity13 on @entity9 volume and recovery of function in a focal XXXX model.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: @entity11 develops very early after the onset of focal @entity12 and may be a major factor in @entity8 after an acute @entity4 . There have been very limited studies on the usefulness of antiedemic agents as neuroprotective agents in the setting of focal @entity12 . We tested the neuroprotective effects of a new potent nonpeptide vasopressin receptor V(1) antagonist, @entity13 , in a focal @entity3 model in @entity0 . METHODS: Focal @entity2 was induced by embolizing a preformed clot into the middle cerebral artery (MCA). @entity9 volume was measured at 48 hours after the @entity10 . @entity1 , @entity11 , @entity5 activity, and mortality and @entity7 rates were also documented. RESULTS: Treatment with @entity13 (2 mg/kg), initiated immediately after @entity10 , significantly reduced @entity9 volume (P<0.05) measured at 48 hours after the @entity6 . In animals in which the treatment was delayed for 1 hour after @entity10 , @entity9 volume was also reduced significantly (P<0.05). @entity9 volume in the @entity0 that received the drug at 3 or 6 hours after @entity10 was not different from that in the vehicle-treated group. Treatment with @entity13 , when started early after the @entity6 , also reduced @entity1 and @entity11 . Injection of drug at a higher dose (30 mg/kg) also reduced @entity9 volume and improved functional recovery but was not superior to the lower dose (2 mg/kg) when the drug was administrated at 1 hour after @entity10 . CONCLUSIONS: Our data show that the selective vasopressin receptor antagonist @entity13 is a potent neuroprotective agent when used early after onset of @entity6 in an embolic focal @entity2 model in @entity0 . Further studies are needed in @entity3 models to better understand its neuroprotective properties when used alone or in combination with thrombolysis.

title: Effects of nonpeptide V(1) vasopressin receptor antagonist XXXX on @entity9 volume and recovery of function in a focal @entity3 model.

answer: @entity13


abstract: PURPOSE: To describe recent characteristics of incidence, risk factors, treatment, and outcome of @entity4 ( @entity4 ) in @entity0 and young adults undergoing blood and bone marrow transplantation (BMT). METHODS: All @entity0 and young adults (n = 241) undergoing first myeloablative transplant at the UCSF Pediatric BMT unit between 1992 and 2000 were included. Retrospective chart review was done. Descriptive statistics and univariate and multivariate analyses of risk factors are presented. RESULTS: @entity4 developed in 65 @entity0 (27%); it was severe in 13/65 @entity0 (20%). Matched unrelated donor transplantation, advanced-stage @entity1 , and transplantation in the recent period (1998-2000) were identified as significant risk factors for @entity4 in univariate and multivariate analyses. Heparin prophylaxis did not decrease the incidence of @entity4 . @entity4 was diagnosed at a median day 8 after BMT. Five of 13 @entity0 with severe @entity4 (38%) survived for more than 1 year after BMT, even after renal and @entity3 and high total @entity2 levels up to 35 mg/dL. Nine of the 13 @entity0 received fibrinolytic treatment with tissue plasminogen activator, anti-thrombin 3, or defibrotide. The survival rate at day 100 after BMT for @entity0 with @entity4 was 77%; it was 94% for those without @entity4 . CONCLUSIONS: The persistently high incidence of @entity4 , its significant impact on posttransplant survival, and the demonstration of recovery from even severe @entity4 underscore the importance of early diagnosis and initiation of specific therapy. The use of Bearman's model of prediction of severity of @entity4 and the application of fibrinolytic drugs when adequate are highly recommended.

title: Hepatic venoocclusive disease in blood and bone marrow transplantation in XXXX and young adults: incidence, risk factors, and outcome in a cohort of 241 @entity0 .

answer: @entity0


abstract: PURPOSE: To describe recent characteristics of incidence, risk factors, treatment, and outcome of @entity4 ( @entity4 ) in @entity0 and young adults undergoing blood and bone marrow transplantation (BMT). METHODS: All @entity0 and young adults (n = 241) undergoing first myeloablative transplant at the UCSF Pediatric BMT unit between 1992 and 2000 were included. Retrospective chart review was done. Descriptive statistics and univariate and multivariate analyses of risk factors are presented. RESULTS: @entity4 developed in 65 @entity0 (27%); it was severe in 13/65 @entity0 (20%). Matched unrelated donor transplantation, advanced-stage @entity1 , and transplantation in the recent period (1998-2000) were identified as significant risk factors for @entity4 in univariate and multivariate analyses. Heparin prophylaxis did not decrease the incidence of @entity4 . @entity4 was diagnosed at a median day 8 after BMT. Five of 13 @entity0 with severe @entity4 (38%) survived for more than 1 year after BMT, even after renal and @entity3 and high total @entity2 levels up to 35 mg/dL. Nine of the 13 @entity0 received fibrinolytic treatment with tissue plasminogen activator, anti-thrombin 3, or defibrotide. The survival rate at day 100 after BMT for @entity0 with @entity4 was 77%; it was 94% for those without @entity4 . CONCLUSIONS: The persistently high incidence of @entity4 , its significant impact on posttransplant survival, and the demonstration of recovery from even severe @entity4 underscore the importance of early diagnosis and initiation of specific therapy. The use of Bearman's model of prediction of severity of @entity4 and the application of fibrinolytic drugs when adequate are highly recommended.

title: Hepatic venoocclusive disease in blood and bone marrow transplantation in @entity0 and young adults: incidence, risk factors, and outcome in a cohort of 241 XXXX .

answer: @entity0


abstract: UNASSIGNED: Finite element analysis (FEA)-based biomechanical modeling can be used to predict lung respiratory motion. In this technique, elastic models and biomechanical parameters are two important factors that determine modeling accuracy. We systematically evaluated the effects of lung and @entity1 biomechanical modeling approaches and related parameters to improve the accuracy of motion simulation of @entity1 center of mass (TCM) displacements. Experiments were conducted with four-dimensional computed tomography (4D-CT). A Quasi-Newton FEA was performed to simulate lung and related @entity2 displacements between end-expiration (phase 50%) and other respiration phases (0%, 10%, 20%, 30%, and 40%). Both linear isotropic and non-linear hyperelastic materials, including the neo-Hookean compressible and uncoupled Mooney-Rivlin models, were used to create a finite element model (FEM) of lung and @entity2 . Lung surface displacement vector fields (SDVFs) were obtained by registering the 50% phase CT to other respiration phases, using the non-rigid demons registration algorithm. The obtained SDVFs were used as lung surface displacement boundary conditions in FEM. The sensitivity of TCM displacement to lung and @entity2 biomechanical parameters was assessed in eight @entity0 for all three models. @entity0 -specific optimal parameters were estimated by minimizing the TCM motion simulation errors between phase 50% and phase 0%. The uncoupled Mooney-Rivlin material model showed the highest TCM motion simulation accuracy. The average TCM motion simulation absolute errors for the Mooney-Rivlin material model along left-right, anterior-posterior, and superior-inferior directions were 0.80   mm, 0.86   mm, and 1.51   mm, respectively. The proposed strategy provides a reliable method to estimate @entity0 -specific biomechanical parameters in FEM for @entity1 motion simulation.

title: Sensitivity of XXXX motion simulation accuracy to lung biomechanical modeling approaches and parameters.

answer: @entity2


abstract: Prior studies have evaluated the teratogenicity of @entity6 , a contaminant of drinking water. However, none specifically examined effects of @entity6 on cardiogenesis. The purpose of this study was to determine if @entity6 is a cardiac teratogen in early embryogenesis in an avian model. Fertile White Leghorn @entity4 eggs were incubated under standard conditions. At stage 6, 12, 18, or 23, @entity6 , in concentrations of 5 to 25 microM (2 to 28 micrograms/g body weight) was injected into the air space of the egg (vol = 0.03 ml). Mineral oil and saline served as control solutions. For this double-blinded study, solutions were coded and remained so until all observations were made and recorded. Embryonic hearts (n = 1055) were examined at stage 29, 34, or 44. Gross examination was performed, followed by microdissection. @entity1 were found in 7.3% of @entity6 -treated hearts, compared to 2.3% of saline controls (p less than 0.01), and 1.5% of mineral oil controls (p less than 0.001). No significant difference in incidence of @entity3 was found when comparing saline and mineral oil controls. @entity1 include @entity5 , cor biloculare, @entity0 , @entity2 , and abnormal cardiac muscle. These data demonstrate that @entity6 is a cardiac teratogen in an avian model.

title: Trichloroethylene: a cardiac teratogen in developing XXXX embryos.

answer: @entity4


abstract: The genome of the geminivirus @entity2 ) consists of two circular DNA molecules designated as components A and B. The A component contains the only virally-encoded function required for autonomous replication in infected plant cells. We used agroinoculation of petunia leaf discs with the A component to develop a transient expression system which permits direct examination of viral transcripts by S1 nuclease protection. The @entity0 gene, which encodes the @entity2 coat protein, was transcribed transiently in leaf discs after agroinoculation of @entity2 a DNA. Synthesis of @entity0 RNA was dependent on T-DNA transfer and @entity2 DNA replication, demonstrating that it is a plant transcription product. The AL open reading frames of @entity2 A were also expressed transiently in leaf discs. The ratio between @entity0 RNA and the major leftward RNA was constant and was used to normalize @entity0 transcription for viral DNA copy number. The bacterial genes encoding @entity1 acetyltransferase (CAT) and beta-glucuronidase (GUS) were transiently expressed in leaf discs from the @entity0 promoter in @entity2 A. The levels of @entity0 and GUS RNAs were similar in leaf discs after adjusting for viral DNA copy number, while CAT RNA was less abundant. The geminivirus transient expression system allows rapid analysis of RNAs transcribed from foreign genes and can serve as a preliminary screen in the construction of transgenic plants.

title: Transient expression of heterologous RNAs using XXXX .

answer: @entity2


abstract: This is a report of three @entity0 with @entity2 , or @entity2 , their genealogic backgrounds and the stereomicroscope and scanning electron microscopic appearances of the hair, the skin of their fingertips and palms as well as skin studies of members of their families. The skin morphology was recorded by means of silicone monomer rubber impressions and @entity1 resin dyes. In two of the @entity0 the disease was acquired by X-linked inheritance, while in the third, a @entity0 , it appeared to follow an autosomal dominant pattern. Defects of the skin of the fingertips and palms of the propositi and members of the families included abnormalities of the morphology and pattern of the epidermal ridges, reduction of sweat pores varying from 13 to 87% of normal, and changed anatomy of the openings of the sweat glands. The openings were shallow and with less whorling compared to the normal, funnel-shaped sweat pores. Among the sweat pores, micropores, or openings with an average diameter of 5.3 micrometers, were observed. One of the propositi and the affected father of another had orifices on their fingertips resembling hair sheaths. Two propositi and the affected father of one exhibited grooving of the hair. The findings confirm the necessity for genealogic investigations in @entity0 with or suspected of having the disease in order to advise parents or prospective parents. They also illustrate the usefulness of stereomicroscopy and scanning electron microscopy in observing skin and hair abnormalities.

title: XXXX : a genealogic, stereomicroscope, and scanning electron microscope study.

answer: @entity2


abstract: BACKGROUND: Little is known about the clinical and immunological features of @entity3 @entity0 with @entity2 . In a large series of adult @entity3 @entity0 , we investigated the prevalence of @entity2 and anti-neuronal antibodies, along with the clinical course. METHODS: @entity2 were investigated in 160 consecutive @entity0 (120 F, 40 M) with biopsy-proven @entity3 . Anti-neuronal antibodies to central/enteric nervous systems were investigated in all neurological @entity0 , 20 unaffected ones and 20 controls. RESULTS: Thirteen (8%) @entity0 had @entity2 , including @entity4 (n = 3), @entity6 (n = 3), @entity8 (n = 2), @entity5 (n = 2), @entity1 (n = 1), @entity9 (n = 1) and @entity7 (n = 1). No significant demographic or clinical differences (gastrointestinal or other gluten-related signs) were found between @entity0 with and without neurological involvement. In all but 2 of the 13 cases, the @entity2 preceded @entity3 . @entity2 improved or disappeared in 7 @entity0 who started a gluten-free diet within 6 months after neurological onset, and in none of 4 @entity0 who began later. Prevalence of central nervous system anti-neuronal antibodies was significantly higher in neurological (61%) than in other @entity0 (5%) (P = 0.0007) or controls (0%) (P = 0.00001). CONCLUSIONS: @entity3 can sometimes present in the guise of a @entity2 , which may greatly improve when a gluten-free diet is started promptly. Therefore, the possible presence of @entity3 needs to be carefully considered in @entity0 with @entity8 , @entity4 , @entity6 or @entity5 .

title: Clinical findings and anti-neuronal antibodies in @entity3 with XXXX .

answer: @entity2


abstract: BACKGROUND: Little is known about the clinical and immunological features of @entity3 @entity0 with @entity2 . In a large series of adult @entity3 @entity0 , we investigated the prevalence of @entity2 and anti-neuronal antibodies, along with the clinical course. METHODS: @entity2 were investigated in 160 consecutive @entity0 (120 F, 40 M) with biopsy-proven @entity3 . Anti-neuronal antibodies to central/enteric nervous systems were investigated in all neurological @entity0 , 20 unaffected ones and 20 controls. RESULTS: Thirteen (8%) @entity0 had @entity2 , including @entity4 (n = 3), @entity6 (n = 3), @entity8 (n = 2), @entity5 (n = 2), @entity1 (n = 1), @entity9 (n = 1) and @entity7 (n = 1). No significant demographic or clinical differences (gastrointestinal or other gluten-related signs) were found between @entity0 with and without neurological involvement. In all but 2 of the 13 cases, the @entity2 preceded @entity3 . @entity2 improved or disappeared in 7 @entity0 who started a gluten-free diet within 6 months after neurological onset, and in none of 4 @entity0 who began later. Prevalence of central nervous system anti-neuronal antibodies was significantly higher in neurological (61%) than in other @entity0 (5%) (P = 0.0007) or controls (0%) (P = 0.00001). CONCLUSIONS: @entity3 can sometimes present in the guise of a @entity2 , which may greatly improve when a gluten-free diet is started promptly. Therefore, the possible presence of @entity3 needs to be carefully considered in @entity0 with @entity8 , @entity4 , @entity6 or @entity5 .

title: Clinical findings and anti-neuronal antibodies in XXXX with @entity2 .

answer: @entity3


abstract: Endoparasites must breach host barriers to establish @entity1 and then must survive host internal defenses to cause disease. Such barriers may frustrate attempts to experimentally transmit @entity2 by 'natural' methods. In addition, the host's condition may affect a study's outcome. The experiments reported here examined the effect of dosing method and host metabolic condition on measures of virulence for the oyster parasite @entity4 . Oysters, @entity3 , were challenged with wild-type and cultured forms of @entity4 via feeding, shell-cavity injection, gut intubation and adductor-muscle injection. For both parasite types, adductor-muscle injections produced the @entity1 followed by shell-cavity injection, gut intubation, and feeding. There was no difference in parasite burdens between oysters fed cultured cells by acute vs chronic dosing, and parasite loads stabilized over time, suggesting a dynamic equilibrium between invasion and elimination. @entity4 distribution among tissues of challenged oysters indicated that @entity2 invaded the mantle and gill, as well as the gut, which has been considered the primary portal of entry. Frequency distributions of @entity4 in oysters challenged with 3 different culture phases indicated an aggregated distribution among hosts and suggested that stationary-phase @entity2 were easiest for the oyster to control or eliminate and log-phase @entity2 were the most difficult. Host metabolic condition also affected experimental outcomes, as indicated by increased @entity1 levels in oysters undergoing spawning and/or exposed to low @entity0 stress.

title: Comparison of in vitro-cultured and wild-type XXXX . II. Dosing methods and host response.

answer: @entity4


abstract: In two field trials in Nigeria, 74 male and female @entity1 outpatients received intra-adipose depot injections of either @entity2 ( @entity4 ) or @entity3 (MADDS) at 4-week intervals. Blood samples were taken regularly and sent to Amsterdam to determine the @entity4 and MADDS concentrations in serum using high-pressure liquid chromatography (HPLC). The @entity4 injection yielded a good sustained drug release. After repeated administration accumulation occurred, demonstrated by a statistically significant increase in the area under the curve (AUC) in time: until 28 days after the first injection, the mean AUC (+/- S.D.) amounted to 19.3 +/- 5.6 mg d/l in males and 15.1 +/- 5.2 in females; after the fourth injection, 26.4 +/- 7.5 and 24.6 +/- 9.0 mg d/l, respectively (p less than 0.001). One male @entity0 developed an abscess at the injection site; otherwise no side effects were observed. Even better sustained-release results were observed with the MADDS injection. Unfortunately, the injection caused a number of abscesses. Consequently, the @entity4 injection was very well received by the @entity0 of the @entity4 study, while half of the @entity0 in the MADDS study would prefer tablets to the MADDS injection. Further investigations are required to find the cause of the abscesses before one of the injections, or possibly a combination of both, could be implemented in the multi-drug treatment regimen proposed by WHO to provide a valuable tool to combat noncompliance among @entity1 @entity0 .

title: A field trial among @entity1 @entity0 in Nigeria with depot injections of XXXX and @entity3 .

answer: @entity2


abstract: In two field trials in Nigeria, 74 male and female @entity1 outpatients received intra-adipose depot injections of either @entity2 ( @entity4 ) or @entity3 (MADDS) at 4-week intervals. Blood samples were taken regularly and sent to Amsterdam to determine the @entity4 and MADDS concentrations in serum using high-pressure liquid chromatography (HPLC). The @entity4 injection yielded a good sustained drug release. After repeated administration accumulation occurred, demonstrated by a statistically significant increase in the area under the curve (AUC) in time: until 28 days after the first injection, the mean AUC (+/- S.D.) amounted to 19.3 +/- 5.6 mg d/l in males and 15.1 +/- 5.2 in females; after the fourth injection, 26.4 +/- 7.5 and 24.6 +/- 9.0 mg d/l, respectively (p less than 0.001). One male @entity0 developed an abscess at the injection site; otherwise no side effects were observed. Even better sustained-release results were observed with the MADDS injection. Unfortunately, the injection caused a number of abscesses. Consequently, the @entity4 injection was very well received by the @entity0 of the @entity4 study, while half of the @entity0 in the MADDS study would prefer tablets to the MADDS injection. Further investigations are required to find the cause of the abscesses before one of the injections, or possibly a combination of both, could be implemented in the multi-drug treatment regimen proposed by WHO to provide a valuable tool to combat noncompliance among @entity1 @entity0 .

title: A field trial among @entity1 @entity0 in Nigeria with depot injections of @entity2 and XXXX .

answer: @entity3


abstract: In two field trials in Nigeria, 74 male and female @entity1 outpatients received intra-adipose depot injections of either @entity2 ( @entity4 ) or @entity3 (MADDS) at 4-week intervals. Blood samples were taken regularly and sent to Amsterdam to determine the @entity4 and MADDS concentrations in serum using high-pressure liquid chromatography (HPLC). The @entity4 injection yielded a good sustained drug release. After repeated administration accumulation occurred, demonstrated by a statistically significant increase in the area under the curve (AUC) in time: until 28 days after the first injection, the mean AUC (+/- S.D.) amounted to 19.3 +/- 5.6 mg d/l in males and 15.1 +/- 5.2 in females; after the fourth injection, 26.4 +/- 7.5 and 24.6 +/- 9.0 mg d/l, respectively (p less than 0.001). One male @entity0 developed an abscess at the injection site; otherwise no side effects were observed. Even better sustained-release results were observed with the MADDS injection. Unfortunately, the injection caused a number of abscesses. Consequently, the @entity4 injection was very well received by the @entity0 of the @entity4 study, while half of the @entity0 in the MADDS study would prefer tablets to the MADDS injection. Further investigations are required to find the cause of the abscesses before one of the injections, or possibly a combination of both, could be implemented in the multi-drug treatment regimen proposed by WHO to provide a valuable tool to combat noncompliance among @entity1 @entity0 .

title: A field trial among XXXX @entity0 in Nigeria with depot injections of @entity2 and @entity3 .

answer: @entity1


abstract: In two field trials in Nigeria, 74 male and female @entity1 outpatients received intra-adipose depot injections of either @entity2 ( @entity4 ) or @entity3 (MADDS) at 4-week intervals. Blood samples were taken regularly and sent to Amsterdam to determine the @entity4 and MADDS concentrations in serum using high-pressure liquid chromatography (HPLC). The @entity4 injection yielded a good sustained drug release. After repeated administration accumulation occurred, demonstrated by a statistically significant increase in the area under the curve (AUC) in time: until 28 days after the first injection, the mean AUC (+/- S.D.) amounted to 19.3 +/- 5.6 mg d/l in males and 15.1 +/- 5.2 in females; after the fourth injection, 26.4 +/- 7.5 and 24.6 +/- 9.0 mg d/l, respectively (p less than 0.001). One male @entity0 developed an abscess at the injection site; otherwise no side effects were observed. Even better sustained-release results were observed with the MADDS injection. Unfortunately, the injection caused a number of abscesses. Consequently, the @entity4 injection was very well received by the @entity0 of the @entity4 study, while half of the @entity0 in the MADDS study would prefer tablets to the MADDS injection. Further investigations are required to find the cause of the abscesses before one of the injections, or possibly a combination of both, could be implemented in the multi-drug treatment regimen proposed by WHO to provide a valuable tool to combat noncompliance among @entity1 @entity0 .

title: A field trial among @entity1 XXXX in Nigeria with depot injections of @entity2 and @entity3 .

answer: @entity0


abstract: Between 1968 and 1983, 135 @entity0 with pathologic stage (PS) I and II @entity6 were treated with extended mantle radiation technique (EMRT) at Michael Reese Hospital and the University of Chicago Center for Radiation Therapy. EMRT combines both standard mantle and para-aorta fields (M-PA) in one port. Actuarial disease-free survival at 5 and 10 years was 82.5%. Actuarial overall survival was 96% and 83% at 5 and 10 years, respectively. Acute complications were evaluated in 112 @entity0 available for analysis. Severe @entity3 and @entity4 occurred in 13%, weight loss of greater than 10% of body weight in 19%, and acute hematologic @entity1 in 4% of @entity0 . @entity2 was transient and did not interfere with subsequent delivery of salvage treatment with either chemotherapy or radiation therapy in 22 @entity0 who relapsed. The cost of EMRT is 40% lower than the cost of treatment with M-PA. The median treatment time was 38 days, 33% less than the 56 days for M-PA field assuming no interruptions. These results suggest that the @entity5 is a safe and effective treatment tolerated by most @entity0 . The advantages of this method are eliminating the possibility of technical error of matching between mantle and para-aortic field, decreasing overall treatment time, and reducing the cost.

title: Extended mantle radiation therapy for pathologic stage I and II XXXX .

answer: @entity6


abstract: PURPOSE: To evaluate the macular function by means of multifocal electroretinogram (MF ERG) in eyes with congenital optic disc pit and @entity1 . The evaluation was performed before and after the successful surgical intervention. DESIGN: Nonrandomized, comparative (self-controlled), interventional trial. @entity0 : Ten @entity0 (10 eyes) with optic disc pit with @entity1 were treated with the macular buckling procedure and followed up from March 1999 through May 2001. METHODS: In all @entity0 included in the study, MF ERG was recorded before and after treatment. For recording, the VERIS III system (Visual Evoked Response Imaging System; Tomey, Nagoya, Japan) was used. MAIN OUTCOME MEASURES: The retinal response densities were studied before and after treatment in areas 1 and 2 and were compared with visual acuity. RESULTS: The MF ERG before treatment showed decreased retinal response densities in all 10 cases. Twelve months after the surgical intervention, the electrical response densities in areas 1 (foveal area) and 2 (parafoveal area) improved. Further improvement was noted in 3 of the 10 @entity0 who completed a follow-up of 18 months after treatment. In 8 of the 10 @entity0 , postoperative visual acuity also increased. In the remaining two @entity0 , visual acuity did not change after treatment, despite improvement of the retinal response densities. CONCLUSIONS: In eyes with congenital optic disc pit with @entity1 , the decrease in retinal electrophysiologic response before treatment was not limited to the fovea, but also involved the perifoveal area. In all 10 eyes 12 months after treatment, the electrical activities in areas 1 and 2 improved. This improvement was not always followed by an increase in visual acuity. In 2 of the 10 @entity0 , visual acuity remained unchanged. The values of retinal response densities before treatment cannot be used alone as a prognostic factor for the postoperative functional retinal results. It should also be stressed that the results of this study cannot be compared with the results of studies where spontaneous resolution of the @entity1 occurred.

title: Preoperative and postoperative assessment by multifocal electroretinography in the management of optic disc pits with XXXX .

answer: @entity1


abstract: UNASSIGNED: Reduced or absent cytotrophoblast invasion of the maternal uterine spiral arterioles is a common clinical finding in studies of pregnancies complicated by preeclampsia, suggesting that the mechanisms mediating invasion of these cells is perturbed. The placenta initially develops in a low @entity0 environment of 1-2% @entity0 until after the 10th week of pregnancy. During this time @entity0 concentration exerts a major influence over trophoblast activity and, @entity1 inducible factors are proposed to be one of many key regulators of first trimester trophoblast behaviour. We used a global gene expression microarray approach to identify signalling pathways and @entity1 -responsive genes of interest involved in invasion of the first trimester trophoblast cell line HTR8/SVneo under @entity1 conditions where @entity5 was active. Additionally, first trimester placental samples from different gestational age groups were labelled with anti @entity5 and @entity2 to evaluate whether HIFs are differentially expressed and localised across two periods of placental development: (1) early first trimester characterised by @entity1 (6-8 weeks) and (2) late first trimester after initiation of maternal blood flow into the placenta (10-12 weeks). Invasion of HTR8/SVneo was assessed in real-time and was significantly increased in 1% compared with 5% and 21% @entity0 and did not differ between 5% and 21% @entity0 treatments. Eighty-eight genes were differentially expressed between cells cultured in 1% @entity0 (where @entity5 protein was localised to the nucleus) and 5% @entity0 (where @entity5 was mainly cytoplasmic). 65% of the genes were predicted to contain @entity5 : @entity7 transcription factor binding sites. While @entity2 staining intensity in trophoblasts of late first trimester placenta was higher than early first trimester (+57%) the percentage of positively stained trophoblast nuclei did not differ between the two time points. There was no difference in the expression level of any of the @entity1 responsive genes of interest, @entity3 , @entity8 , @entity9 , @entity6 and @entity4 between early and late first trimester placenta. While @entity5 and its downstream targets are clearly induced in HTR8/SVneo during in vitro @entity1 conditions, it appears that @entity1 inducible factors and genes are not altered throughout the first 7-12 weeks of placental development, during which the onset of maternal blood flow to the intervillous space takes place.

title: XXXX induced @entity5 /HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.

answer: @entity1


abstract: UNASSIGNED: Reduced or absent cytotrophoblast invasion of the maternal uterine spiral arterioles is a common clinical finding in studies of pregnancies complicated by preeclampsia, suggesting that the mechanisms mediating invasion of these cells is perturbed. The placenta initially develops in a low @entity0 environment of 1-2% @entity0 until after the 10th week of pregnancy. During this time @entity0 concentration exerts a major influence over trophoblast activity and, @entity1 inducible factors are proposed to be one of many key regulators of first trimester trophoblast behaviour. We used a global gene expression microarray approach to identify signalling pathways and @entity1 -responsive genes of interest involved in invasion of the first trimester trophoblast cell line HTR8/SVneo under @entity1 conditions where @entity5 was active. Additionally, first trimester placental samples from different gestational age groups were labelled with anti @entity5 and @entity2 to evaluate whether HIFs are differentially expressed and localised across two periods of placental development: (1) early first trimester characterised by @entity1 (6-8 weeks) and (2) late first trimester after initiation of maternal blood flow into the placenta (10-12 weeks). Invasion of HTR8/SVneo was assessed in real-time and was significantly increased in 1% compared with 5% and 21% @entity0 and did not differ between 5% and 21% @entity0 treatments. Eighty-eight genes were differentially expressed between cells cultured in 1% @entity0 (where @entity5 protein was localised to the nucleus) and 5% @entity0 (where @entity5 was mainly cytoplasmic). 65% of the genes were predicted to contain @entity5 : @entity7 transcription factor binding sites. While @entity2 staining intensity in trophoblasts of late first trimester placenta was higher than early first trimester (+57%) the percentage of positively stained trophoblast nuclei did not differ between the two time points. There was no difference in the expression level of any of the @entity1 responsive genes of interest, @entity3 , @entity8 , @entity9 , @entity6 and @entity4 between early and late first trimester placenta. While @entity5 and its downstream targets are clearly induced in HTR8/SVneo during in vitro @entity1 conditions, it appears that @entity1 inducible factors and genes are not altered throughout the first 7-12 weeks of placental development, during which the onset of maternal blood flow to the intervillous space takes place.

title: @entity1 induced XXXX /HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.

answer: @entity5


abstract: BACKGROUND: Allergen immunotherapy is currently the only disease-modifying treatment available for @entity3 and @entity1 . OBJECTIVES: We sought to evaluate the induction of sustained tolerance to allergen when anti- @entity4 was combined with a suboptimal course of grass pollen @entity5 ( @entity5 ) using the allergen-induced skin late-phase response (LPR) and exploratory immune monitoring as surrogate markers of therapeutic response. METHODS: In this randomized, double-blind, 3-group parallel design trial, 37 @entity0 with @entity3 received suboptimal @entity5 (30,000 standardized quality units) in combination with anti- @entity4 (VAK694) and suboptimal @entity5 (30,000 standardized quality units) plus placebo antibody or double placebo (placebo @entity5 and placebo antibody) restricted to 13  weeks before the grass pollen season. The primary end point was the size of the LPR at 12  months. Exploratory end points included measures of the immunomodulatory activity of treatment by using @entity4 and @entity2 FluoroSpot assays, flow cytometry of T  cells, and measurement of IgE, IgG4, and facilitated antigen binding. RESULTS: Both active treatment arms led to a substantial and sustained reduction of the LPR with no additional suppression with addition of anti- @entity4 . Treatment with anti- @entity4 and @entity5 compared with @entity5 alone led to a sustained reduction in allergen-specific @entity4 -producing cell counts (P  <  .01). Both active treatment arms led to induction of dual @entity4 / @entity2 -producing cells during the pollen season. CONCLUSION: The combination of anti- @entity4 with @entity5 provided no additional benefit over @entity5 alone in suppressing the allergen-induced skin LPR. A  larger trial is needed to assess whether the observed ex  vivo downregulation of TH2 responses might translate into clinical benefit.

title: Short-term subcutaneous grass pollen immunotherapy under the umbrella of anti- XXXX : A  randomized controlled trial.

answer: @entity4


abstract: Tuning curves, spontaneous activity, and rate-intensity (RI) functions were obtained from units in the @entity0 cochlear nerve. The @entity1 ( @entity1 ) was determined from each tuning curve. The shape of each RI function was subjectively evaluated and assigned to one of four RI types. The breakpoint, discharge rate at the highest SPLs, and slopes of the primary and secondary segments were quantified for each function. The @entity1 and RI type were then related to these variables. A new RI function was observed in which the discharge activity in the secondary segment diminished as stimulus level increased above the breakpoint. This function was called a "sloping-down" type. In 959 units, saturating, sloping-up, sloping-down, and straight RI types were identified in 39.2, 35.5, 12.6, and 12.7% of the sample, respectively. The slope of the primary segment was nearly the same in each of the four types and averaged 5.48 S. s(-1). dB(-1) across all units. The slopes of the secondary segments formed four groupings when segregated by RI type based on the subjective assignments and averaged 0.03, 1.22, -0.90, and 3.95 S. s(-1). dB(-1) in the saturating, sloping-up, sloping-down, and straight types, respectively. The data describing the secondary segments of all units were fit with a multi-compartment polynomial and showed a continuous distribution that segregated, with some overlap, into the different RI categories. The proportion of RI types, as well as the secondary and primary slopes were approximately constant across CFs. In addition, it would appear that the other parameters that define the four types were, for the most part, homogeneously distributed across the frequency axis of the @entity0 inner ear. Finally, a comparison of RI functions having a common @entity1 suggested that the compressive nonlinearity that determines RI type may be a phenomenon localized to individual hair cells in the bird ear.

title: Coding of sound intensity in the XXXX cochlear nerve.

answer: @entity0


abstract: The efficacy of @entity6 (DP), @entity4 (MX), @entity7 (AP) and @entity5 (CZ) on @entity2 was compared (single drug therapy). In addition, the efficacy of the combination therapy of DP with MX was also studied (combination therapy). One hundred of the 106 @entity0 completed the protocol of the single drug therapy. Fifty percent or more reduction in the frequency of ventricular premature contractions (VPCs) was obtained in 24 of 43 @entity0 (56%) with DP, in 24 of 44 (55%) with MX, in 18 of 29 (62%) with AP and 10 of 18 (56%) with CZ. AP was comparatively more effective than the other drugs tested. DP was significantly effective on VPCs with @entity1 as compared to idiopathic VPCs (p less than 0.05), while the other 3 drugs did not have such a tendency. With MX therapy, 10 of the 12 @entity0 with fast VT rate (greater than or equal to 150 beats/min) showed a significant effect while only 4 of the 12 @entity0 with non-fast VT rate (greater than or equal to 100 and 150 beats/min) had a significant one (p less than 0.05). On the other hand, DP, AP and CZ showed almost the same efficacy at any cycle length of VT. Six @entity0 withdrew from the study, 4 because of digestive troubles with MX therapy, 1 because of micturition disturbances with DP and 1 because of @entity3 with AP. The average therapeutic plasma levels of DP, MX, AP and CZ were 1.76 +/- 0.54 microgram/ml, 1.08 +/- 0.41 microgram/ml, 0.85 +/- 0.43 microgram/ml and 268.2 +/- 123.3 ng/ml, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for XXXX .

answer: @entity2


abstract: OBJECTIVE: The purpose of this study was to determine whether a common bromelain regimen or common @entity5 regimen are effective in resolving @entity3 and @entity2 associated with delayed onset @entity4 of the elbow flexors. DESIGN: A randomized, double-blinded, repeated measures design was used for this study. SETTING: The study was performed in the Sports Injury Research Lab at an NCAA Division I university. @entity0 : Forty subjects who had not participated in an upper body resistance-training program 3 months prior to the study, suffered @entity3 in the nondominant arm, or experienced an adverse response to nonsteroidal anti-inflammatory drugs or pineapple (bromelain source) were recruited. Thirty-nine subjects finished the study. INTERVENTIONS: Active range of motion (ROM), perceived @entity3 , and peak concentric torque measurements of the nondominant arm were taken prior to and 24, 48, 72, and 96 hours following an eccentric exercise protocol of the elbow flexors. Subjects were assigned to one of four treatment groups (bromelain 300 mg t.i.d., @entity5 400 mg t.i.d., placebo t.i.d., and control) and began treatment immediately following the exercise protocol. MAIN OUTCOME MEASURES: No differences among treatments were observed for any of the dependent variables at any time. @entity1 and @entity3 peaked between 48 and 72 hours. @entity6 were observed between 24 and 72 hours. CONCLUSIONS: Ingestion of bromelain and @entity5 had no effect on elbow flexor @entity3 , loss of ROM, or loss of concentric peak torque as a result of an eccentric exercise regimen.

title: Preliminary comparison of bromelain and XXXX for delayed onset @entity4 management.

answer: @entity5


abstract: OBJECTIVE: The purpose of this study was to determine whether a common bromelain regimen or common @entity5 regimen are effective in resolving @entity3 and @entity2 associated with delayed onset @entity4 of the elbow flexors. DESIGN: A randomized, double-blinded, repeated measures design was used for this study. SETTING: The study was performed in the Sports Injury Research Lab at an NCAA Division I university. @entity0 : Forty subjects who had not participated in an upper body resistance-training program 3 months prior to the study, suffered @entity3 in the nondominant arm, or experienced an adverse response to nonsteroidal anti-inflammatory drugs or pineapple (bromelain source) were recruited. Thirty-nine subjects finished the study. INTERVENTIONS: Active range of motion (ROM), perceived @entity3 , and peak concentric torque measurements of the nondominant arm were taken prior to and 24, 48, 72, and 96 hours following an eccentric exercise protocol of the elbow flexors. Subjects were assigned to one of four treatment groups (bromelain 300 mg t.i.d., @entity5 400 mg t.i.d., placebo t.i.d., and control) and began treatment immediately following the exercise protocol. MAIN OUTCOME MEASURES: No differences among treatments were observed for any of the dependent variables at any time. @entity1 and @entity3 peaked between 48 and 72 hours. @entity6 were observed between 24 and 72 hours. CONCLUSIONS: Ingestion of bromelain and @entity5 had no effect on elbow flexor @entity3 , loss of ROM, or loss of concentric peak torque as a result of an eccentric exercise regimen.

title: Preliminary comparison of bromelain and @entity5 for delayed onset XXXX management.

answer: @entity4


abstract: 21 @entity0 with @entity5 were treated at this clinic over a period of 3 years. 15 @entity0 had metapneumonic @entity4 , 2 @entity4 associated with @entity3 , and 4 postsurgical @entity4 . In 12 @entity0 the underlying illness was @entity1 while 9 @entity0 were thus far in good health. The most frequent causative pathogens were staphylococci and streptococci, together with anaerobic bacteria. One @entity0 died of the underlying disease. Three cases of metapneumonic @entity4 healed completely with antibiotics only. Closed chest tube drainage with small chest tube was performed 13 times and was successful 11 times with a mean drainage duration of 13 days. Six @entity0 underwent surgery (early decortication in 4 instances, late decortication in 2). The surgical indication was in 4 instances multilocular of the @entity4 which inhibited chest tube drainage, imminent loss of function in 1 case and unsuccessful drainage in a case of @entity2 in 1 instance. Apart from high-dose antibiotic therapy, earliest possible drainage is of crucial importance in the treatment of @entity5 . Surgery should be considered only in uncomplicated @entity4 if drainage is impossible for technical reasons.

title: [Diagnosis and therapy of XXXX ].

answer: @entity5


abstract: This prospective study was conducted at Dhaka Medical College and Hospital, Bangladesh. The objective was to identify the time required to control high blood pressure levels in @entity3 @entity0 by injection of @entity4 in a bolus intravenous dose vs continuous drip. Seventy-seven @entity0 with @entity5 and @entity1 emergencies comprised the target population. @entity0 were managed either by @entity4 drip in normal saline (existing official protocol, n = 33) or @entity4 bolus injection (as experiment, n = 44) until diastolic blood pressure fell to 90-95 mmHg. Results were compared. Student's t-test was done for statistical significance, and a P value of <.05 was considered as significant. The groups were similar with respect to maternal age and their mean systolic and diastolic blood pressure at the time of enrollment. @entity0 who received bolus injection required less time to achieve the therapeutic goal (65.23 +/- 23.38 minutes) than continuous drip (186.36 +/- 79.77 minutes; P <.001). The experimental group also required significantly lower doses (6.68 +/- 1.66 mg) in comparison to that required by control group (20.07 +/- 11.38 mg; P <.001). There was no overshoot @entity2 in either group. The data suggest that @entity4 bolus dose is equally safe and more effective than continuous drip in the management of @entity1 emergencies in pregnancy.

title: Management of @entity1 emergencies of pregnancy by XXXX bolus injection vs continuous drip--a comparative study.

answer: @entity4


abstract: This prospective study was conducted at Dhaka Medical College and Hospital, Bangladesh. The objective was to identify the time required to control high blood pressure levels in @entity3 @entity0 by injection of @entity4 in a bolus intravenous dose vs continuous drip. Seventy-seven @entity0 with @entity5 and @entity1 emergencies comprised the target population. @entity0 were managed either by @entity4 drip in normal saline (existing official protocol, n = 33) or @entity4 bolus injection (as experiment, n = 44) until diastolic blood pressure fell to 90-95 mmHg. Results were compared. Student's t-test was done for statistical significance, and a P value of <.05 was considered as significant. The groups were similar with respect to maternal age and their mean systolic and diastolic blood pressure at the time of enrollment. @entity0 who received bolus injection required less time to achieve the therapeutic goal (65.23 +/- 23.38 minutes) than continuous drip (186.36 +/- 79.77 minutes; P <.001). The experimental group also required significantly lower doses (6.68 +/- 1.66 mg) in comparison to that required by control group (20.07 +/- 11.38 mg; P <.001). There was no overshoot @entity2 in either group. The data suggest that @entity4 bolus dose is equally safe and more effective than continuous drip in the management of @entity1 emergencies in pregnancy.

title: Management of XXXX emergencies of pregnancy by @entity4 bolus injection vs continuous drip--a comparative study.

answer: @entity1


abstract: Moderate reductions (< or = 15%) in body @entity3 , similar to those observed after administration of some chemopreventive agents in chemically induced mammary @entity0 models, will result in @entity0 (up to 55%). The objective of this study was to determine whether changes in mammary gland differentiation, proliferation, apoptosis, and @entity2 and @entity4 levels are affected by moderate reductions in body weight induced after chemopreventive agent treatment and dietary restriction. The body weights of female @entity1 were reduced by dietary restrictions to match those of @entity1 receiving @entity7 ( @entity7 ) at a dose known to inhibit @entity5 ( @entity6 )-induced mammary @entity0 . @entity7 supplementation or dietary restrictions began 1 wk before MNU administration at 50 days of age. Mammary gland differentiation, proliferation, apoptosis, and serum levels of @entity2 and @entity4 were measured at 50, 57, and 71 days of age. Casein expression, proliferating cellular nuclear antigen expression, and apoptosis were not significantly different from controls in the dietary-restricted group. Proliferating cellular nuclear antigen expression was significantly lower in @entity7 -treated animals than in controls at 57 days of age. The diameter of the mammary gland ducts was smaller at 71 days of age in the treatment groups. A decrease in @entity2 levels for each group was observed at 50 days of age, but not at later time points. @entity4 levels were reduced in the @entity7 group, but not in the dietary-restricted group, during each time period. It would appear that the observed decrease in mammary @entity0 observed with moderate reductions in body @entity3 might be due to multiple related factors different from those related to @entity7 treatment.

title: Effects of body XXXX reduction resulting from chemopreventive agent treatment on mammary gland morphology.

answer: @entity3