abstract: UNASSIGNED: Cardiovascular @entity0 take @entity1 ( @entity5 ) for preventing @entity2 and other @entity3 . It is already known that in some @entity0 this therapy is not effective. The aim of this study was to assess the percentage of @entity5 resistance on the sample of @entity0 with coronary artery bypass grafting. Our study included 105 @entity0 with coronary artery bypass grafting treated with @entity5 150mg/day or lesser. Platelet aggregation was measured by serum @entity4 level as well as impedance aggregometry from whole blood to determine @entity5 antiaggregation effect. The percentage of @entity5 resistance was 41.9% with impedance aggregometry, and after determining the serum @entity4 level this percentage was only 8.6%. The correlation between these two methods was weak (r=0.443; P<0.0001). @entity3 complications still occur in @entity5 -treated @entity0 because some @entity0 are resistant to @entity5 therapy. It would be useful to monitor the effectiveness of @entity5 therapy and give another antiaggregation drug to these @entity0 to reduce adverse events. The problem is which test is ideal because different tests show different percentages of @entity5 resistance.

title: The monitoring of antiaggregation effect of @entity1 therapy by measuring serum XXXX in @entity0 with coronary artery bypass grafting.

answer: @entity4


abstract: UNASSIGNED: Cardiovascular @entity0 take @entity1 ( @entity5 ) for preventing @entity2 and other @entity3 . It is already known that in some @entity0 this therapy is not effective. The aim of this study was to assess the percentage of @entity5 resistance on the sample of @entity0 with coronary artery bypass grafting. Our study included 105 @entity0 with coronary artery bypass grafting treated with @entity5 150mg/day or lesser. Platelet aggregation was measured by serum @entity4 level as well as impedance aggregometry from whole blood to determine @entity5 antiaggregation effect. The percentage of @entity5 resistance was 41.9% with impedance aggregometry, and after determining the serum @entity4 level this percentage was only 8.6%. The correlation between these two methods was weak (r=0.443; P<0.0001). @entity3 complications still occur in @entity5 -treated @entity0 because some @entity0 are resistant to @entity5 therapy. It would be useful to monitor the effectiveness of @entity5 therapy and give another antiaggregation drug to these @entity0 to reduce adverse events. The problem is which test is ideal because different tests show different percentages of @entity5 resistance.

title: The monitoring of antiaggregation effect of @entity1 therapy by measuring serum @entity4 in XXXX with coronary artery bypass grafting.

answer: @entity0


abstract: BACKGROUND: Although @entity4 nasal spray (MFNS) has demonstrated efficacy in @entity2 ( @entity2 ) in Western populations, data in Asian populations is limited. METHODS: This randomized, double-blind study evaluated MFNS 200  g twice per day ( @entity3 ) vs placebo in Chinese adults with bilateral nasal polyps (graded as 1, 2, or 3 by the investigator). A 14-day placebo run-in period was followed by a 16-week treatment period with MFNS 200  g @entity3 vs placebo (1:1 ratio). The co-primary endpoints were change from baseline in nasal congestion/obstruction averaged over the first 4 weeks of treatment and change from baseline in the total polyp size score (sum of scores from the left and right nasal fossa) at week 16. Secondary endpoints included other sinonasal symptoms scores and safety outcomes such as monitoring laboratory measurements, vital signs, and adverse events (AEs). RESULTS: There were 748 @entity0 randomized, 375 received MFNS 200  g @entity3 and 373 received placebo. The between-treatment difference in least squares (LS) mean change from baseline in nasal congestion/obstruction over 4 weeks of treatment was -0.14 (95% confidence interval [CI], -0.22 to -0.06) for MFNS vs placebo (p = 0.0007). The between-treatment difference in LS mean change from baseline in total polyp size score at week 16 was -0.30 (95% CI, -0.45 to -0.15) for MFNS vs placebo (p < 0.0001). Serious AEs were rare (0.5% and 0.8% in MFNS and placebo groups, respectively) and considered not drug-related. There were significantly more @entity1 with MFNS vs placebo (p = 0.009). CONCLUSION: This study demonstrated that MFNS was effective and well tolerated in this population of adult, Chinese @entity0 with @entity2 .

title: @entity4 nasal spray in the treatment of XXXX in Chinese @entity0 : a double-blind, randomized, placebo-controlled trial.

answer: @entity2


abstract: BACKGROUND: Although @entity4 nasal spray (MFNS) has demonstrated efficacy in @entity2 ( @entity2 ) in Western populations, data in Asian populations is limited. METHODS: This randomized, double-blind study evaluated MFNS 200  g twice per day ( @entity3 ) vs placebo in Chinese adults with bilateral nasal polyps (graded as 1, 2, or 3 by the investigator). A 14-day placebo run-in period was followed by a 16-week treatment period with MFNS 200  g @entity3 vs placebo (1:1 ratio). The co-primary endpoints were change from baseline in nasal congestion/obstruction averaged over the first 4 weeks of treatment and change from baseline in the total polyp size score (sum of scores from the left and right nasal fossa) at week 16. Secondary endpoints included other sinonasal symptoms scores and safety outcomes such as monitoring laboratory measurements, vital signs, and adverse events (AEs). RESULTS: There were 748 @entity0 randomized, 375 received MFNS 200  g @entity3 and 373 received placebo. The between-treatment difference in least squares (LS) mean change from baseline in nasal congestion/obstruction over 4 weeks of treatment was -0.14 (95% confidence interval [CI], -0.22 to -0.06) for MFNS vs placebo (p = 0.0007). The between-treatment difference in LS mean change from baseline in total polyp size score at week 16 was -0.30 (95% CI, -0.45 to -0.15) for MFNS vs placebo (p < 0.0001). Serious AEs were rare (0.5% and 0.8% in MFNS and placebo groups, respectively) and considered not drug-related. There were significantly more @entity1 with MFNS vs placebo (p = 0.009). CONCLUSION: This study demonstrated that MFNS was effective and well tolerated in this population of adult, Chinese @entity0 with @entity2 .

title: XXXX nasal spray in the treatment of @entity2 in Chinese @entity0 : a double-blind, randomized, placebo-controlled trial.

answer: @entity4


abstract: BACKGROUND: Although @entity4 nasal spray (MFNS) has demonstrated efficacy in @entity2 ( @entity2 ) in Western populations, data in Asian populations is limited. METHODS: This randomized, double-blind study evaluated MFNS 200  g twice per day ( @entity3 ) vs placebo in Chinese adults with bilateral nasal polyps (graded as 1, 2, or 3 by the investigator). A 14-day placebo run-in period was followed by a 16-week treatment period with MFNS 200  g @entity3 vs placebo (1:1 ratio). The co-primary endpoints were change from baseline in nasal congestion/obstruction averaged over the first 4 weeks of treatment and change from baseline in the total polyp size score (sum of scores from the left and right nasal fossa) at week 16. Secondary endpoints included other sinonasal symptoms scores and safety outcomes such as monitoring laboratory measurements, vital signs, and adverse events (AEs). RESULTS: There were 748 @entity0 randomized, 375 received MFNS 200  g @entity3 and 373 received placebo. The between-treatment difference in least squares (LS) mean change from baseline in nasal congestion/obstruction over 4 weeks of treatment was -0.14 (95% confidence interval [CI], -0.22 to -0.06) for MFNS vs placebo (p = 0.0007). The between-treatment difference in LS mean change from baseline in total polyp size score at week 16 was -0.30 (95% CI, -0.45 to -0.15) for MFNS vs placebo (p < 0.0001). Serious AEs were rare (0.5% and 0.8% in MFNS and placebo groups, respectively) and considered not drug-related. There were significantly more @entity1 with MFNS vs placebo (p = 0.009). CONCLUSION: This study demonstrated that MFNS was effective and well tolerated in this population of adult, Chinese @entity0 with @entity2 .

title: @entity4 nasal spray in the treatment of @entity2 in Chinese XXXX : a double-blind, randomized, placebo-controlled trial.

answer: @entity0


abstract: The authors reviewed 29 cases of @entity12 treated from 1973 to 1993 with an average follow-up time of 7.4 years. Clinical findings included back @entity6 , @entity11 , @entity10 , @entity8 , @entity4 , and bowel and @entity9 . Twenty-two @entity0 (76%) presented with @entity1 ; 12 (41%) were initially misdiagnosed. Sixteen @entity0 (55%) had predominant vertebral body involvement; nine had marked @entity3 with neurological compromise. Eleven individuals (39%) had intraspinal granulomatous tissue causing @entity1 in the absence of @entity3 , and two (7%) had intramedullary @entity14 . All patients received antituberculous medications: 13 were initially treated with bracing alone, eight underwent laminectomy and debridement of extra- or intradural granulomatous tissue, and eight underwent anterior, posterior, or combined fusion procedures. No @entity0 with @entity1 recovered or stabilized with nonoperative management. Thirteen @entity0 were readmitted with progression of inadequately treated @entity13 ; 12 (92%) of these required new or more radical fusion procedures. @entity7 was associated with marked @entity10 and @entity2 requiring a graft that spanned more than two disc spaces. Courses of antibiotic medications shorter than 6 months were invariably associated with disease recurrence. It was concluded that 1) @entity0 should receive at least 12 months of appropriate antituberculous therapy; 2) individuals with @entity1 should undergo surgical decompression; 3) laminectomy and debridement are adequate for intraspinal granulomatous tissue in the absence of significant @entity3 ; 4) when vertebral body involvement has produced wedging and @entity10 , @entity5 debridement and fusion are indicated to prevent delayed instability and progression of disease.

title: XXXX : a diagnostic and management challenge.

answer: @entity12


abstract: Self monitoring of @entity1 requires technical knowledge and suitable @entity1 oriented behaviour; the latter arises from the @entity0 's psycho-affective functioning, maturity and self sufficiency. A group of 9 insulin dependent ambulatory, adult, @entity1 met 15 times over 5 months. The somatic and psycho-affective aspects of the disease were approached by an original methodology. Group animation was focussed on the @entity0 themselves. Dynamic mobilisation of the @entity0 was sought by listening to their explicit and implicit requests, by acting out (case studies and role-playing), by restatement and questioning. @entity1 oriented and psycho-affective behaviours were assessed on the basis of questionnaires and statements. At the end of the study, the psycho-affective attitude of the @entity0 towards their illness was modified. The @entity2 , mockery and rejection of @entity1 and @entity1 , initially noted, were progressively replaced by self-awareness and acceptance. As a result, better adjustment of technical behaviour responses was noted. Without precluding any psychodynamic explanation (reunification of the @entity0 ), this study suggests that the @entity0 's reactions towards their own image can be improved with consequential educational benefit.

title: [A broad educational approach to insulin-dependent XXXX ].

answer: @entity1


abstract: BACKGROUND: Lung strain, defined as the ratio between end-inspiratory volume and functional residual capacity, is a marker of the mechanical load during ventilation. However, changes in lung volumes in response to pressures may occur in injured lungs and modify strain values. The objective of this study was to clarify the role of recruitment in strain measurements. METHODS: Six @entity3 -injured @entity2 were ventilated at positive end-expiratory pressure (PEEP) 0 and 10 cm @entity4 before and after a recruitment maneuver (PEEP = 20 cm @entity4 ). Lung volumes were measured by helium dilution and inductance plethysmography. In addition, six @entity0 with moderate-to-severe acute @entity1 were ventilated with three strategies (peak inspiratory pressure/PEEP: 20/8, 32/8, and 32/20 cm @entity4 ). Lung volumes were measured in computed tomography slices acquired at end-expiration and end-inspiration. From both series, recruited volume and lung strain (total, dynamic, and static) were computed. RESULTS: In the animal model, recruitment caused a significant decrease in dynamic strain (from [mean    SD] 0.4    0.12 to 0.25    0.07, P < 0.01), while increasing the static component. In @entity0 , total strain remained constant for the three ventilatory settings (0.35    0.1, 0.37    0.11, and 0.32    0.1, respectively). Increases in tidal volume had no significant effects. Increasing PEEP constantly decreased dynamic strain (0.35    0.1, 0.32    0.1, and 0.04+0.03, P < 0.05) and increased static strain (0, 0.06    0.06, and 0.28    0.11, P < 0.05). The changes in dynamic and total strain among @entity0 were correlated to the amount of recruited volume. An analysis restricted to the changes in normally aerated lung yielded similar results. CONCLUSION: Recruitment causes a shift from dynamic to static strain in early acute @entity1 .

title: Impact of Recruitment on Static and Dynamic Lung Strain in Acute XXXX .

answer: @entity1


abstract: The pathological changes in @entity2 are heterogeneous and may depend on the primary disease process. Renal function is better correlated with tubular and interstitial changes than with glomerular changes detectable in simple two-dimensional sections. Atubular glomeruli have been demonstrated in many @entity5 . They constitute a significant portion of the glomerular population in some @entity4 . The atubular glomeruli are generally small, but they have open capillaries and minor ultrastructural changes. The number of capillaries is decreased. Glomeruli connected to normal proximal tubules have volumes at the normal level or above. They have not been shown to be eliminated. The presence of atubular glomeruli may explain the correlation between the volume of proximal tubules and the volume of interstitium, on the one hand, and altered renal function on the other. The presence of atubular glomeruli could explain the irreversibility of @entity4 . It is likely that @entity1 and @entity3 in themselves contribute to the decrease in renal function of both @entity0 . In @entity0 , the @entity0 and hyperfiltration may play the major part in the pathogenesis of the deterioration of renal function. The available evidence points toward glomerulo-tubular disconnection as an important and common cause of progression and irreversibility of @entity4 . It provides a simple explanation for the common observation of severely reduced kidney function and mostly normal-looking glomeruli--at least in two dimensions.

title: Atubular glomeruli in XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity6 ( @entity6 HH103 is a broad host-range @entity2 -fixing bacterium able to nodulate many legumes, including @entity1 . In several rhizobia, root nodulation is influenced by proteins secreted through the type 3 secretion system (T3SS). This specialized secretion apparatus is a common virulence mechanism of many plant and animal pathogenic bacteria that delivers proteins, called effectors, directly into the eukaryotic host cells where they interfere with signal transduction pathways and promote @entity0 by suppressing host defenses. In rhizobia, secreted proteins, called nodulation outer proteins (Nops), are involved in host-range determination and symbiotic efficiency. @entity7 secretes at least eight Nops through the T3SS. Interestingly, there are Rhizobium-specific Nops, such as NopC, which do not have homologues in pathogenic bacteria. In this work we studied the @entity7 nopC gene and confirmed that its expression was regulated in a @entity4 -, NodD1- and TtsI-dependent manner. Besides, in vivo bioluminescent studies indicated that the @entity7 T3SS was expressed in young @entity1 nodules and @entity3 cyclase assays confirmed that NopC was delivered directly into @entity1 root cells by means of the T3SS machinery. Finally, nodulation assays showed that NopC exerted a positive effect on symbiosis with @entity1 cv. Williams 82 and @entity5 . All these results indicate that NopC can be considered a Rhizobium-specific effector secreted by @entity7 .

title: NopC Is a Rhizobium-Specific Type 3 Secretion System Effector Secreted by @entity6 ( XXXX HH103.

answer: @entity6


abstract: UNASSIGNED: @entity6 ( @entity6 HH103 is a broad host-range @entity2 -fixing bacterium able to nodulate many legumes, including @entity1 . In several rhizobia, root nodulation is influenced by proteins secreted through the type 3 secretion system (T3SS). This specialized secretion apparatus is a common virulence mechanism of many plant and animal pathogenic bacteria that delivers proteins, called effectors, directly into the eukaryotic host cells where they interfere with signal transduction pathways and promote @entity0 by suppressing host defenses. In rhizobia, secreted proteins, called nodulation outer proteins (Nops), are involved in host-range determination and symbiotic efficiency. @entity7 secretes at least eight Nops through the T3SS. Interestingly, there are Rhizobium-specific Nops, such as NopC, which do not have homologues in pathogenic bacteria. In this work we studied the @entity7 nopC gene and confirmed that its expression was regulated in a @entity4 -, NodD1- and TtsI-dependent manner. Besides, in vivo bioluminescent studies indicated that the @entity7 T3SS was expressed in young @entity1 nodules and @entity3 cyclase assays confirmed that NopC was delivered directly into @entity1 root cells by means of the T3SS machinery. Finally, nodulation assays showed that NopC exerted a positive effect on symbiosis with @entity1 cv. Williams 82 and @entity5 . All these results indicate that NopC can be considered a Rhizobium-specific effector secreted by @entity7 .

title: NopC Is a Rhizobium-Specific Type 3 Secretion System Effector Secreted by XXXX ( @entity6 HH103.

answer: @entity6


abstract: @entity1 in the spermatic cord is infrequent. Further, among such cases, it is extremely rare to encounter a @entity3 other than a nonepithelial @entity1 ; almost all are @entity0 . We recently experienced an interesting case of spermatic @entity6 in a 78-year-old male. He entered our hospital with the chief complaint of a right inguinal @entity1 . He underwent 2 operations to excise the @entity1 . The extirpated @entity1 mass from the right spermatic cord was composed of @entity4 with abundant @entity2 , which is considered to be @entity0 from the other viscerae. We were unable to find the primary focus in spite of extensive clinical and pathological examinations. In an autopsy about four months after the 2nd operation, the @entity1 was confirmed to be primary @entity5 , which is called @entity7 . There have been only 20 cases of metastatic spermatic @entity6 reported in Japan. However, we considered that this is the 1st case caused by @entity7 in Japan and even in other countries.

title: [A case of XXXX of the spermatic cord due to @entity7 ].

answer: @entity3


abstract: @entity1 in the spermatic cord is infrequent. Further, among such cases, it is extremely rare to encounter a @entity3 other than a nonepithelial @entity1 ; almost all are @entity0 . We recently experienced an interesting case of spermatic @entity6 in a 78-year-old male. He entered our hospital with the chief complaint of a right inguinal @entity1 . He underwent 2 operations to excise the @entity1 . The extirpated @entity1 mass from the right spermatic cord was composed of @entity4 with abundant @entity2 , which is considered to be @entity0 from the other viscerae. We were unable to find the primary focus in spite of extensive clinical and pathological examinations. In an autopsy about four months after the 2nd operation, the @entity1 was confirmed to be primary @entity5 , which is called @entity7 . There have been only 20 cases of metastatic spermatic @entity6 reported in Japan. However, we considered that this is the 1st case caused by @entity7 in Japan and even in other countries.

title: [A case of @entity3 of the spermatic cord due to XXXX ].

answer: @entity7


abstract: OBJECTIVE: To validate the In-hospital Mortality for @entity2 using Claims daTa (IMPACT) multivariable prediction rule using admission claims data. STUDY DESIGN: Retrospective claims database analysis. METHODS: This analysis was performed using Humana admission claims data from January 2007 to March 2014. We included adult @entity0 admitted for their first PE during this period (International Classification of Diseases, ninth edition, Clinical Modification code of 415.1x in in the primary position or secondary position when accompanied by a primary code for a @entity1 ). The IMPACT rule, consisting of age plus 11 comorbidities, was used to estimate @entity0 ' probability of in-hospital mortality and classify risk. Low risk was defined as in-hospital mortality  <= 1.5%. IMPACT was evaluated by evaluating prognostic test characteristic values and 95% confidence intervals (CIs). RESULTS: A total of 23,858 @entity0 admitted for PE were included, and 3.3% died in-hospital. The IMPACT prediction rule classified 2371 (9.9%) as low-risk; with a sensitivity of 97.6%, 95% CI: 96.1-98.5, specificity of 10.2%, 95% CI: 9.8-10.6, negative and positive predictive values of 99.2% (95% CI: 98.7-99.5) and 3.5% (95% CI: 3.3-3.8) and c-statistic of 0.70, 95% CI: 0.0.68-0.72, for in-hospital mortality. IMPACT classified 42.7% of @entity0 < 65 years old as low-risk; with a sensitivity, specificity and c-statistic of 85.0%, 95% CI: 77.4-90.5, 43.3%, 95% CI: 42.0-44.7 and 0.74, 95% CI: 0.69-0.78, respectively. CONCLUSION: The IMPACT prediction rule was valid when implemented in a database consisting largely of Medicare claims. Following further external validation and direct comparison to commonly used clinical prediction rules, IMPACT may become a valuable tool for payers and hospitals wishing to retrospectively assess whether their PE @entity0 are being kept hospitalized for the optimal period of time.

title: External validation of the In-hospital Mortality for XXXX using Claims daTa (IMPACT) multivariable prediction rule.

answer: @entity2


abstract: Transplant @entity6 is a major late complication in @entity0 heart allograft recipients and the pathogenesis of @entity6 remains uncertain. The degree to which lipids and atheromata are involved in the @entity2 remains unsettled, and there is uncertainty regarding the significance of insudation or retention of lipids within the coronary artery walls of transplanted hearts. On current immunosuppressive regimens, most @entity0 experience an increased serum total @entity3 and low-density lipoprotein @entity3 after transplant. Elevation of these blood lipids has an undetermined relationship to @entity6 . We carried out morphological, morphometric, immunohistochemical, ultrastructural, and biochemical studies of particular coronary artery segments from 23 unselected explant or autopsy allografts and donor age-matched native coronary controls. @entity0 died of cardiac and non-cardiac reasons over a period of 4 to 1610 days after transplant. Atheromata were frequent, and diffuse intra- and extra-cellular accumulation of lipids in both intimal and medial walls was documented by oil red O positivity, immunohistochemical staining (muscle-specific alpha-actin), transmission and scanning electron microscopy, and biochemical analysis. Mean total @entity3 , esterified @entity3 , free @entity3 , and phospholipid content (microgram/cm2 intimal surface area) and concentration (microgram/mg dry defatted weight) in arteriopathic coronaries were > 10-fold higher than in comparable native coronary segments. Extent of lipids in the arterial walls was highly correlated with digitized percent luminal narrowing, mean daily and cumulative @entity4 dose, and mean cumulative @entity5 dose. Our data suggests strongly that lipid accumulation is an important early and persistent phenomenon in the development of @entity1 .

title: Prominence of coronary arterial wall lipids in @entity0 heart allografts. Implications for pathogenesis of XXXX .

answer: @entity6


abstract: Transplant @entity6 is a major late complication in @entity0 heart allograft recipients and the pathogenesis of @entity6 remains uncertain. The degree to which lipids and atheromata are involved in the @entity2 remains unsettled, and there is uncertainty regarding the significance of insudation or retention of lipids within the coronary artery walls of transplanted hearts. On current immunosuppressive regimens, most @entity0 experience an increased serum total @entity3 and low-density lipoprotein @entity3 after transplant. Elevation of these blood lipids has an undetermined relationship to @entity6 . We carried out morphological, morphometric, immunohistochemical, ultrastructural, and biochemical studies of particular coronary artery segments from 23 unselected explant or autopsy allografts and donor age-matched native coronary controls. @entity0 died of cardiac and non-cardiac reasons over a period of 4 to 1610 days after transplant. Atheromata were frequent, and diffuse intra- and extra-cellular accumulation of lipids in both intimal and medial walls was documented by oil red O positivity, immunohistochemical staining (muscle-specific alpha-actin), transmission and scanning electron microscopy, and biochemical analysis. Mean total @entity3 , esterified @entity3 , free @entity3 , and phospholipid content (microgram/cm2 intimal surface area) and concentration (microgram/mg dry defatted weight) in arteriopathic coronaries were > 10-fold higher than in comparable native coronary segments. Extent of lipids in the arterial walls was highly correlated with digitized percent luminal narrowing, mean daily and cumulative @entity4 dose, and mean cumulative @entity5 dose. Our data suggests strongly that lipid accumulation is an important early and persistent phenomenon in the development of @entity1 .

title: Prominence of coronary arterial wall lipids in XXXX heart allografts. Implications for pathogenesis of @entity6 .

answer: @entity0


abstract: UNASSIGNED: Evidence shows that @entity4 can induce brain structural reorganization. Acupuncture is advised as an adjunct to mainstream rehabilitation after @entity2 . However, the effectiveness of acupuncture is inconsistent among previous studies. Fourteen @entity1 @entity0 were collected and divided into two groups: conventional treatment group (CG) and acupuncture treatment group (AG). The results of a Fugl-Meyer Assessment (FMA) and diffusion tensor imaging were collected before and after treatment. The AG exhibited a higher improvement in FMA than the CG. Repeated measures analysis of variance on diffusion data only found a significant main effect for scanning time point in all diffusion indices. In each group, a postpair t-test revealed that diffusion indices values were changed significantly after treatment intervention in the body of the corpus callosum and bilateral corticospinal tracts, the @entity3 , the cingulum gyrus, and the thalamic radiation. However, there was no significant difference in the diffusion indices between the two groups. In conclusion, acupuncture had a better behavioral score than traditional medicine treatment. However, acupuncture did not significantly change WM in the AG compared to the CG as expected within one month after the intervention.

title: The Effect of Acupuncture on the Motor Function and White Matter Microstructure in XXXX @entity0 .

answer: @entity4


abstract: UNASSIGNED: Evidence shows that @entity4 can induce brain structural reorganization. Acupuncture is advised as an adjunct to mainstream rehabilitation after @entity2 . However, the effectiveness of acupuncture is inconsistent among previous studies. Fourteen @entity1 @entity0 were collected and divided into two groups: conventional treatment group (CG) and acupuncture treatment group (AG). The results of a Fugl-Meyer Assessment (FMA) and diffusion tensor imaging were collected before and after treatment. The AG exhibited a higher improvement in FMA than the CG. Repeated measures analysis of variance on diffusion data only found a significant main effect for scanning time point in all diffusion indices. In each group, a postpair t-test revealed that diffusion indices values were changed significantly after treatment intervention in the body of the corpus callosum and bilateral corticospinal tracts, the @entity3 , the cingulum gyrus, and the thalamic radiation. However, there was no significant difference in the diffusion indices between the two groups. In conclusion, acupuncture had a better behavioral score than traditional medicine treatment. However, acupuncture did not significantly change WM in the AG compared to the CG as expected within one month after the intervention.

title: The Effect of Acupuncture on the Motor Function and White Matter Microstructure in @entity4 XXXX .

answer: @entity0


abstract: BACKGROUND: The objective of this study was to determine the prevalence of electrocardiographic (ECG) findings suggestive of @entity6 risk in apparently healthy young Korean @entity0 . METHODS: We administered questionnaires that elicited personal and family histories and performed ECGs on 10,867 male subjects (mean age, 20.9 years). The subjects with abnormal ECG findings underwent echocardiography, a treadmill test, Holter monitoring, a @entity9 provocation test, or an electrophysiologic study (EPS) according to the ECG findings and histories. RESULTS: Of the subjects, 5.95% had left @entity2 on ECG, but no subjects had @entity5 by echocardiography. The percentage of subjects with a Brugada ECG pattern was 0.90%. We identified one subject with a positive result on the @entity9 provocation test. The percentage of subjects with a preexcitation ECG was 0.17%. In two of the subjects, @entity8 was induced in the EPS. Of the subjects, 0.05% had epsilon waves, but there were no subjects with @entity7 right @entity1 / @entity3 by echocardiography. The percentage of subjects with long QT intervals was 0.02%, but there were no @entity4 on the treadmill test or Holter monitoring. CONCLUSIONS: The prevalence of a Brugada ECG pattern in apparently healthy young @entity0 is higher in Korea than other countries.

title: Prevalence of electrocardiographic findings suggestive of XXXX risk in 10,867 apparently healthy young Korean @entity0 .

answer: @entity6


abstract: BACKGROUND: The objective of this study was to determine the prevalence of electrocardiographic (ECG) findings suggestive of @entity6 risk in apparently healthy young Korean @entity0 . METHODS: We administered questionnaires that elicited personal and family histories and performed ECGs on 10,867 male subjects (mean age, 20.9 years). The subjects with abnormal ECG findings underwent echocardiography, a treadmill test, Holter monitoring, a @entity9 provocation test, or an electrophysiologic study (EPS) according to the ECG findings and histories. RESULTS: Of the subjects, 5.95% had left @entity2 on ECG, but no subjects had @entity5 by echocardiography. The percentage of subjects with a Brugada ECG pattern was 0.90%. We identified one subject with a positive result on the @entity9 provocation test. The percentage of subjects with a preexcitation ECG was 0.17%. In two of the subjects, @entity8 was induced in the EPS. Of the subjects, 0.05% had epsilon waves, but there were no subjects with @entity7 right @entity1 / @entity3 by echocardiography. The percentage of subjects with long QT intervals was 0.02%, but there were no @entity4 on the treadmill test or Holter monitoring. CONCLUSIONS: The prevalence of a Brugada ECG pattern in apparently healthy young @entity0 is higher in Korea than other countries.

title: Prevalence of electrocardiographic findings suggestive of @entity6 risk in 10,867 apparently healthy young Korean XXXX .

answer: @entity0


abstract: To evaluate the long-term effects of @entity4 on the myocardium of the young @entity0 we examined 34 @entity0 who had been treated with @entity4 in childhood. In addition to @entity3 , the @entity0 were treated with other potentially @entity2 substances within the framework of different protocols. The mean cumulative @entity3 dose was 128.6 mg/m2, the average age at onset of chemotherapy 4.2 years, and the time interval after discontinuation of treatment 9.0 years. The cardiological examination consisted of a physical examination, electrocardiography and echocardiography, including Doppler and bio-impedance cardiography. The @entity0 were studied at rest and after physical exercise with a cycle ergometer test in a supine position. The results of the physical examination, the electrocardiogram at rest and the 24 h Holter monitoring were normal. The left ventricular enddiastolic diameter, shortening fraction, velocity of fibre shortening (VCF), the diastolic flow profile at the mitral valve level and the @entity1 at rest were also normal. However, the shortening fraction (SF) was below the margin of 2 standard deviations in two @entity0 and the VCF in three @entity0 . There was a significant reduction in septal thickness, (-1.4 SD, P < 0.0004), in the width of left ventricular posterior wall (-1.5 SD, P > 0.0002) and in the left ventricular myocardial mass (-0.76 SD, P = 0.0042). Physical working capacity was normal. Immediately after physical stress the expected rise of SF and VCF did not occur and the SF fell below the values at rest. In comparison to a healthy control group the SF and the VCF were markedly decreased (P > 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Late effects of XXXX therapy in childhood in relation to the function of the heart at rest and under physical stress.

answer: @entity3


abstract: OBJECTIVE: The authors describe their experience with @entity2 ( @entity2 ) recipients undergoing noncardiac surgery and delineate surgical, anesthetic, and logistic factors important in the successful intraoperative management of these @entity0 . SUMMARY BACKGROUND DATA: Left ventricular assist-devices have become part of the armamentarium in the treatment of end-stage @entity1 . As the numbers of @entity0 chronically supported with long-term implantable devices grows, general surgical problems that are commonly seen in other hospitalized @entity0 are becoming manifest. Of particular interest is the intraoperative management of @entity0 undergoing elective noncardiac surgical procedures. METHODS: The anesthesia records and clinical charts were reviewed for eight ventricular assist-device recipients undergoing general surgical procedures between August 1, 1990 and August 31, 1994. RESULTS: A total of 12 procedures were performed in 6 @entity0 and 2 @entity0 averaging 52.7 years of age. Mean time elapsed from device implantation to operation was 68 +/- 35 days. Conventional inhalational and intravenous anesthetic techniques were well tolerated in these @entity0 undergoing diverse surgical procedures. No perioperative mortality was observed. Five of eight @entity0 went on to successful cardiac transplantation. CONCLUSIONS: Hemodynamic recovery after @entity2 insertion has defined a new group of @entity0 who develop noncardiac surgical problems often seen in other @entity3 @entity0 . Recognition of the unique potential problems that the @entity2 recipient may encounter in the perioperative period--in particular @entity0 positioning, device limitations, and fluid and inotropic management--will ensure an optimal surgical outcome for @entity2 recipients undergoing noncardiac surgery.

title: Noncardiac surgery in long-term implantable XXXX recipients.

answer: @entity2


abstract: BACKGROUND: The primary aim of U-CARE (Unexplained Cardiac Arrest Registry of Europe) is to collect clinical information on survivors about a documented episode of @entity6 ( @entity6 ) and to follow these @entity0 (pts) prospectively to acquire information on 1) recurrence of malignant @entity2 or @entity4 , 2) development of a previously non obvious @entity1 , 3) potential difference in outcome in pts treated with different drugs or devices. METHODS AND RESULTS: Within April 15th, 1994, eighty-six pts have been enrolled, 65 males and 21 females. The mean age at the time of the first @entity4 was 35 +/- 15 years. Clinical evaluation revealed "minor" functional or anatomical abnormalities in 14 subjects and they were excluded from the analysis. In the remaining 72 pts, no abnormalities were found at echocardiogram, Holter, angiography, exercise stress test. At the electrophysiologic study 35/68 pts were inducible. Thirty-eight pts received pharmacologic therapy, 28 an implantable defibrillator ( @entity5 ), three pts received both an @entity5 and drug therapy and three were left untreated. Follow-up data are available for 37 pts with a mean follow-up of 4.4 +/- 2.6 years. No @entity0 had evidence of structural @entity1 . Twenty-three pts remained asymptomatic, 12 (32%) had a recurrence of @entity3 or @entity4 : three died suddenly and 2 were defibrillated by the @entity5 . This study that represents the largest experience in @entity6 , shows: 1) all @entity0 remained free from any @entity1 at follow-up, 2) they have a high risk of recurrence of major arrhythmic events. CONCLUSIONS: An @entity5 implant would be appropriate in this population, at least until data on the efficacy of the pharmacologic therapy will be available.

title: [ XXXX : from a collection of clinical cases to a prospective evaluation. The U-CARE Steering Committee. Unexplained Cardiac Arrest Registry of Europe].

answer: @entity6


abstract: @entity2 is a @entity3 with pathologic sequelae that become apparent after a number of years. @entity0 with @entity2 generally present with @entity5 , and diagnosis is eventually established through observation of the @entity0 during sleep. @entity0 with @entity2 snore loudly and experience nocturnal @entity1 desaturation and repetitive disruptions from sleep that eventually lead to daytime @entity5 . Numerous complex interactive pathophysiologic events occur during each obstructive episode, and it is important for the clinician to be aware of the cardiopulmonary, neurologic, and anatomic abnormalities associated with this condition. The anatomic configuration of the pharynx and the physiologic response to occlusion of the upper airway have a major role in the pathogenesis of this disorder. Alveolar ventilation during an apneic episode is immediately reduced to zero, and the metabolic demands for @entity1 must be met by @entity1 stores within the body. With repetitive episodes of obstruction, the @entity1 stores within the lungs are diminished and the rate of arterial @entity9 desaturation increases. During @entity6 , the systemic blood pressure increases while heart rate and cardiac output decrease. Bradydysrhythmias have been noted with the obstructive @entity6 , and @entity4 are associated with episodes of severe @entity9 desaturation. Coexisting @entity8 in @entity0 with @entity2 contributes to the development of @entity7 , serious gas exchange derangement, and general cardiovascular instability.

title: XXXX : a @entity3 .

answer: @entity2


abstract: @entity2 is a @entity3 with pathologic sequelae that become apparent after a number of years. @entity0 with @entity2 generally present with @entity5 , and diagnosis is eventually established through observation of the @entity0 during sleep. @entity0 with @entity2 snore loudly and experience nocturnal @entity1 desaturation and repetitive disruptions from sleep that eventually lead to daytime @entity5 . Numerous complex interactive pathophysiologic events occur during each obstructive episode, and it is important for the clinician to be aware of the cardiopulmonary, neurologic, and anatomic abnormalities associated with this condition. The anatomic configuration of the pharynx and the physiologic response to occlusion of the upper airway have a major role in the pathogenesis of this disorder. Alveolar ventilation during an apneic episode is immediately reduced to zero, and the metabolic demands for @entity1 must be met by @entity1 stores within the body. With repetitive episodes of obstruction, the @entity1 stores within the lungs are diminished and the rate of arterial @entity9 desaturation increases. During @entity6 , the systemic blood pressure increases while heart rate and cardiac output decrease. Bradydysrhythmias have been noted with the obstructive @entity6 , and @entity4 are associated with episodes of severe @entity9 desaturation. Coexisting @entity8 in @entity0 with @entity2 contributes to the development of @entity7 , serious gas exchange derangement, and general cardiovascular instability.

title: @entity2 : a XXXX .

answer: @entity3


abstract: BACKGROUND: Acne scars are difficult to treat. @entity1 ( @entity1 ) is a technique using high strength @entity5 ( @entity6 ) focally on the @entity4 to induce collagenization and cosmetic improvement. OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of @entity1 technique using 100% @entity6 in @entity9 in dark skin types IV and V. METHODS: Thirty @entity0 with ice pick @entity4 were initially primed for 2 weeks before the procedure. The priming agents used were @entity8 4% applied in the morning and tretinoin 0.025% in the night. Sunscreens were advised to prevent @entity3 . Subsequently, they underwent focal application of 100% @entity6 with a wooden toothpick in each individual scar, at 2 weekly intervals, for four sessions. Improvement was assessed by the physician, photographic assessment by an independent investigator, and @entity0 feedback by visual analogue scale after the fourth treatment. RESULTS: Excellent improvement (more than 70%) was observed in the majority of @entity0 (73.3%), while 20% @entity0 showed good improvement (50-70%) and 6.7% @entity0 had fair results (30-49%) at the end of four sessions. Transient @entity7 was observed in one @entity0 and @entity3 in two @entity0 . However, no significant adverse effects such as prolonged pigmentary changes or scarring were noted. CONCLUSION: Treatment of ice pick @entity4 with the @entity1 technique using high strength 100% @entity6 is a safe, minimally invasive, efficacious, and cost-effective technique in darker skin. Adequate priming and continued use of @entity8 and @entity2 reduces complications and promotes healing.

title: Evaluation of XXXX technique with 100% @entity6 in the management of ice pick @entity4 in darker skin types.

answer: @entity1


abstract: BACKGROUND: Acne scars are difficult to treat. @entity1 ( @entity1 ) is a technique using high strength @entity5 ( @entity6 ) focally on the @entity4 to induce collagenization and cosmetic improvement. OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of @entity1 technique using 100% @entity6 in @entity9 in dark skin types IV and V. METHODS: Thirty @entity0 with ice pick @entity4 were initially primed for 2 weeks before the procedure. The priming agents used were @entity8 4% applied in the morning and tretinoin 0.025% in the night. Sunscreens were advised to prevent @entity3 . Subsequently, they underwent focal application of 100% @entity6 with a wooden toothpick in each individual scar, at 2 weekly intervals, for four sessions. Improvement was assessed by the physician, photographic assessment by an independent investigator, and @entity0 feedback by visual analogue scale after the fourth treatment. RESULTS: Excellent improvement (more than 70%) was observed in the majority of @entity0 (73.3%), while 20% @entity0 showed good improvement (50-70%) and 6.7% @entity0 had fair results (30-49%) at the end of four sessions. Transient @entity7 was observed in one @entity0 and @entity3 in two @entity0 . However, no significant adverse effects such as prolonged pigmentary changes or scarring were noted. CONCLUSION: Treatment of ice pick @entity4 with the @entity1 technique using high strength 100% @entity6 is a safe, minimally invasive, efficacious, and cost-effective technique in darker skin. Adequate priming and continued use of @entity8 and @entity2 reduces complications and promotes healing.

title: Evaluation of @entity1 technique with 100% XXXX in the management of ice pick @entity4 in darker skin types.

answer: @entity6


abstract: BACKGROUND: Acne scars are difficult to treat. @entity1 ( @entity1 ) is a technique using high strength @entity5 ( @entity6 ) focally on the @entity4 to induce collagenization and cosmetic improvement. OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of @entity1 technique using 100% @entity6 in @entity9 in dark skin types IV and V. METHODS: Thirty @entity0 with ice pick @entity4 were initially primed for 2 weeks before the procedure. The priming agents used were @entity8 4% applied in the morning and tretinoin 0.025% in the night. Sunscreens were advised to prevent @entity3 . Subsequently, they underwent focal application of 100% @entity6 with a wooden toothpick in each individual scar, at 2 weekly intervals, for four sessions. Improvement was assessed by the physician, photographic assessment by an independent investigator, and @entity0 feedback by visual analogue scale after the fourth treatment. RESULTS: Excellent improvement (more than 70%) was observed in the majority of @entity0 (73.3%), while 20% @entity0 showed good improvement (50-70%) and 6.7% @entity0 had fair results (30-49%) at the end of four sessions. Transient @entity7 was observed in one @entity0 and @entity3 in two @entity0 . However, no significant adverse effects such as prolonged pigmentary changes or scarring were noted. CONCLUSION: Treatment of ice pick @entity4 with the @entity1 technique using high strength 100% @entity6 is a safe, minimally invasive, efficacious, and cost-effective technique in darker skin. Adequate priming and continued use of @entity8 and @entity2 reduces complications and promotes healing.

title: Evaluation of @entity1 technique with 100% @entity6 in the management of ice pick XXXX in darker skin types.

answer: @entity4


abstract: OBJECTIVE: To describe the strategies adopted to increase anti- @entity1 vaccination coverage in @entity0 over 24, as well as the record systems which exist in Castilla-La Mancha health centres. In addition, to determine those factors involved in achieving greater coverage which depend on the primary care team (PCT). DESIGN: An observational study of a crossover type. SETTING: Primary care. @entity0 : The PCT in Castilla-La Mancha existing in 1993. 72.5% reply rate. MEASUREMENTS AND MAIN RESULTS: The average coverage achieved, weighted according to population, was 10.55%. The main risk groups in which strategies to increase coverage were put into practice were: the chronically ill (49.5%), professionals at risk (37.6%) and pregnant @entity0 (32.6%). @entity0 were summoned for follow-up doses by 41.3% of PCTs as a matter of habit and by 41.3% occasionally. Normally the vaccination was recorded in the Medical Notes by 41.9% of PCTs. A linear tendency between a higher vaccination rate and, on the other hand, both greater insistence that @entity0 attend for revaccination (p = 0.01) and better recording in the medical notes (p = 0.04) was confirmed. Vaccination coverage was significantly greater in health centres where less @entity0 were seen (p < 0.001) and which were more modern (p = 0.003). CONCLUSIONS: The low anti- @entity1 vaccination coverage found justifies setting up initiatives of demonstrated efficacy to increase anti- @entity1 immunisation. Better records and insistence on @entity0 ' attendance for follow-up doses are factors linked to greater vaccination coverage.

title: [ XXXX vaccination in adults: the situation in primary care].

answer: @entity1


abstract: An allophanic soil (AS) catalyzed the formation of dark-colored polymers via polycondensation reactions between @entity6 and @entity4 . The organic @entity3 content of the AS was increased from 0.16% to 1.3%, indicating that some of the dark-colored polymers had been adsorbed to the AS. The characteristics of the dark-colored polymers adsorbed on the AS were similar to those of a humin that is not extractable with an aqueous alkaline solution. Such a humin-like substance (HuLS) was separated from the AS by treatment with a mixture of HF and @entity5 . The HuLS and humic acid-like substance (HaLS), comprising the acid-insoluble fraction in the reaction mixture, were characterized by elemental analysis, size exclusion chromatography, pyrolysis-GC/ @entity0 and @entity7 NMR. However, the structural features of HaLS and HuLS had many points in common. These results suggest that HuLS-AS can be regarded as an organo-clay complex formed by the strong adsorption of HaLS to the AS. The adsorption of @entity1 ( @entity2 ) to AS and HuLS-AS was examined at pH 5.5. At this pH, the zeta potential of the HuLS-AS showed a negative value. It would, therefore, be expected that @entity8 anions would adsorb with difficulty to HuLS-AS because of electrostatic repulsion. Nevertheless, the adsorption coefficient for @entity2 to HuLS-AS, as estimated by the Freundlich isotherm, was seven times larger than that for AS. These results show that HuLS, when adsorbed on the AS surface, has the capability to enhance the adsorption of @entity2 .

title: Characterization of an adsorbed humin-like substance on an allophanic soil formed via catalytic polycondensation between @entity6 and @entity4 , and its adsorption capability to XXXX .

answer: @entity1


abstract: An allophanic soil (AS) catalyzed the formation of dark-colored polymers via polycondensation reactions between @entity6 and @entity4 . The organic @entity3 content of the AS was increased from 0.16% to 1.3%, indicating that some of the dark-colored polymers had been adsorbed to the AS. The characteristics of the dark-colored polymers adsorbed on the AS were similar to those of a humin that is not extractable with an aqueous alkaline solution. Such a humin-like substance (HuLS) was separated from the AS by treatment with a mixture of HF and @entity5 . The HuLS and humic acid-like substance (HaLS), comprising the acid-insoluble fraction in the reaction mixture, were characterized by elemental analysis, size exclusion chromatography, pyrolysis-GC/ @entity0 and @entity7 NMR. However, the structural features of HaLS and HuLS had many points in common. These results suggest that HuLS-AS can be regarded as an organo-clay complex formed by the strong adsorption of HaLS to the AS. The adsorption of @entity1 ( @entity2 ) to AS and HuLS-AS was examined at pH 5.5. At this pH, the zeta potential of the HuLS-AS showed a negative value. It would, therefore, be expected that @entity8 anions would adsorb with difficulty to HuLS-AS because of electrostatic repulsion. Nevertheless, the adsorption coefficient for @entity2 to HuLS-AS, as estimated by the Freundlich isotherm, was seven times larger than that for AS. These results show that HuLS, when adsorbed on the AS surface, has the capability to enhance the adsorption of @entity2 .

title: Characterization of an adsorbed humin-like substance on an allophanic soil formed via catalytic polycondensation between XXXX and @entity4 , and its adsorption capability to @entity1 .

answer: @entity6


abstract: An allophanic soil (AS) catalyzed the formation of dark-colored polymers via polycondensation reactions between @entity6 and @entity4 . The organic @entity3 content of the AS was increased from 0.16% to 1.3%, indicating that some of the dark-colored polymers had been adsorbed to the AS. The characteristics of the dark-colored polymers adsorbed on the AS were similar to those of a humin that is not extractable with an aqueous alkaline solution. Such a humin-like substance (HuLS) was separated from the AS by treatment with a mixture of HF and @entity5 . The HuLS and humic acid-like substance (HaLS), comprising the acid-insoluble fraction in the reaction mixture, were characterized by elemental analysis, size exclusion chromatography, pyrolysis-GC/ @entity0 and @entity7 NMR. However, the structural features of HaLS and HuLS had many points in common. These results suggest that HuLS-AS can be regarded as an organo-clay complex formed by the strong adsorption of HaLS to the AS. The adsorption of @entity1 ( @entity2 ) to AS and HuLS-AS was examined at pH 5.5. At this pH, the zeta potential of the HuLS-AS showed a negative value. It would, therefore, be expected that @entity8 anions would adsorb with difficulty to HuLS-AS because of electrostatic repulsion. Nevertheless, the adsorption coefficient for @entity2 to HuLS-AS, as estimated by the Freundlich isotherm, was seven times larger than that for AS. These results show that HuLS, when adsorbed on the AS surface, has the capability to enhance the adsorption of @entity2 .

title: Characterization of an adsorbed humin-like substance on an allophanic soil formed via catalytic polycondensation between @entity6 and XXXX , and its adsorption capability to @entity1 .

answer: @entity4


abstract: Intellectual deterioration may be observed in the course of @entity2 . Since it had been reported that central cholinergic systems degenerate in @entity3 and @entity3 , we measured the activity of @entity5 acetyltransferase (C.A.T.) and the number of muscarinic receptors in various cortical regions of 12 control subjects and 20 @entity0 and compared these biochemical results with clinical and neuropathological data concerning the @entity0 . Thirteen of the @entity2 @entity0 showed signs of intellectual decline (moderate in 8, severe in 5) and neuropathological examination of the cortex revealed in 10 cases large number of @entity3 changes extending beyond the hippocampus. C.A.T. activity was decreased in the cerebral cortex in every @entity0 . The decrease was greater in intellectually deteriorated @entity0 and in the group with numerous senile changes in the cortex. The number of muscarinic receptors was increased in @entity0 that had been treated with anticholinergic drugs until they died, but also in those who had not received these drugs, suggesting and underlying denervation @entity1 . In the caudate nucleus, however, neither C.A.T. activity nor muscarinic receptor number was altered, indicating that the cortical cholinergic lesion was specific. Although in most cases @entity4 in @entity2 was of the Alzheimer type, the case of a @entity2 @entity0 in whom cortical C.A.T. activity was severely decreased, in spite of the absence of cortical histopathological evidence characteristic of @entity3 , suggests that a @entity2 different from the Alzheimer type also exists. In @entity2 as in @entity3 . activity in the cerebral cortex results from degeneration of the cholinergic neurones in the nucleus of Meynert which projects to the cortex. Although the severity of @entity6 seems in relationship with the extent of degeneration, this could already begin before intellectual impairment is apparent.

title: [ @entity4 and XXXX : biochemical and anatomo-clinical correlation].

answer: @entity2


abstract: Intellectual deterioration may be observed in the course of @entity2 . Since it had been reported that central cholinergic systems degenerate in @entity3 and @entity3 , we measured the activity of @entity5 acetyltransferase (C.A.T.) and the number of muscarinic receptors in various cortical regions of 12 control subjects and 20 @entity0 and compared these biochemical results with clinical and neuropathological data concerning the @entity0 . Thirteen of the @entity2 @entity0 showed signs of intellectual decline (moderate in 8, severe in 5) and neuropathological examination of the cortex revealed in 10 cases large number of @entity3 changes extending beyond the hippocampus. C.A.T. activity was decreased in the cerebral cortex in every @entity0 . The decrease was greater in intellectually deteriorated @entity0 and in the group with numerous senile changes in the cortex. The number of muscarinic receptors was increased in @entity0 that had been treated with anticholinergic drugs until they died, but also in those who had not received these drugs, suggesting and underlying denervation @entity1 . In the caudate nucleus, however, neither C.A.T. activity nor muscarinic receptor number was altered, indicating that the cortical cholinergic lesion was specific. Although in most cases @entity4 in @entity2 was of the Alzheimer type, the case of a @entity2 @entity0 in whom cortical C.A.T. activity was severely decreased, in spite of the absence of cortical histopathological evidence characteristic of @entity3 , suggests that a @entity2 different from the Alzheimer type also exists. In @entity2 as in @entity3 . activity in the cerebral cortex results from degeneration of the cholinergic neurones in the nucleus of Meynert which projects to the cortex. Although the severity of @entity6 seems in relationship with the extent of degeneration, this could already begin before intellectual impairment is apparent.

title: [ XXXX and @entity2 : biochemical and anatomo-clinical correlation].

answer: @entity4


abstract: OBJECTIVES: To evaluate the influence of chemomechanical caries removal on bond strengths of three adhesive systems to caries-affected @entity0 dentine. METHODS: 45 extracted @entity0 third molars with occlusal moderate caries were used. One half of each cavity was prepared with chemomechanical method and the other half with bur as the control. Three adhesive systems, Prime_Bond NT (Dentsply, Germany) without any previous conditioning, an etch-and-rinse adhesive (One-Step, Bisco, USA) and a self-etching adhesive (Adper Prompt-L-Pop, 3M ESPE, USA), were applied. The compomer or resin crowns were, then, built up. The prepared specimens were sectioned for @entity2 ( @entity2 ) examination and microtensile bond strength (MTBS) testing. Data were analysed using two-way ANOVA with subsequent application of Student-Newman-Keuls test at p<0.05. RESULTS: Opened dentinal tubules and less smear layer were visible by @entity2 after chemomechanical caries removal, whilst an obvious smear layer covering the dentine surface with occluded tubules was exhibited after bur excavation. Resin tags were seen only in specimens with chemomechanical excavation when Prime_Bond NT system was applied. Statistical analysis of the values of MTBS failed to show significant difference between caries removal methods. However, the values of MTBS for One-Step system achieved with two caries removal methods were both significant higher than other adhesive systems. CONCLUSIONS: @entity1 removal did not influence the bond strengths of the adhesive systems used in this study to caries-affected @entity0 dentine. Highest bond strength was achieved with application of etch-and-rinse adhesive system.

title: Morphological and microtensile bond strength evaluation of three adhesive systems to caries-affected XXXX dentine with chemomechanical caries removal.

answer: @entity0


abstract: The noradrenergic innervation of the @entity0 thymus during pregnancy and the post partum period was examined by a sucrose @entity3 method for @entity2 , and by high pressure liquid chromatography. Fluorescent nerves decreased in number throughout pregnancy when there was an overall loss in thymic weight due to cortical involution. These changes are maximal by parturition. There was a dramatic increase in nerves between d 21 of pregnancy and d 1 after parturition, especially in the capsule and around blood vessels in the connective tissue septa. The neonates were removed at parturition and thymic weight was rapidly regained. The increased numbers of nerves remained throughout this post partum period. @entity1 levels in the thymus altered in a similar pattern throughout pregnancy and the post partum period, but did not parallel thymic weight changes. The mean @entity1 concentration in the virgin thymus was 1063 +/- 107 pg/mg protein. Levels remained similar during early pregnancy and increased significantly at d 16. Virgin levels were regained by d 21. Values peaked after parturition but rapidly decreased over the next 3 days, and remained at or below virgin levels to d 28 except for a transient rise at d 10 post partum. Adrenaline values were consistently below detection levels. This study shows that there are variations in both nerves visualised, and in neurotransmitter ( @entity1 ) content in the thymus during the course of pregnancy and the post partum period. Thus thymic function could be influenced by central events (levels of @entity2 in peripheral blood) as well as local events mediated by transmitter changes in nerves.

title: The noradrenergic innervation of the XXXX thymus during pregnancy and in the post partum period.

answer: @entity0


abstract: BACKGROUND: Dermatosurgery has been gaining in importance in recent years. STUDY AIMS: The aim of our study was to describe this activity to increase its value and to inform the other specialists and the general public. @entity0 AND METHODS: We performed a national prospective study during one month in the hospital centers and university teaching hospitals in France and among the members of the Surgical Group of the Soci  t   fran  aise de dermatologie. Data were collected with a pre-established questionnaire. They were captured on EpiData 3.1 and Excel software package and were analysed using the SPSS 15.0 software package. RESULTS: The participation of dermatology departments in hospital was 66.7 %. For the members of the surgical group, it was 43.1 %. A total of 2308 dermatological surgical procedures was performed. The mean age was 55.5 years    20.7. Three hundred and thirty-six (14.6 %) procedures were performed with antiplatelet agents or anticoagulants. The excisions of @entity1 were carry out with no previous biopsy in 71.3 % of cases. We described repairs in one time in the majority of cases (92.2 %), and the most frequent type of procedure was direct closure (83.4 %). Complete excision was obtained directly in 95.2 % of cases and the clinicopathological correlation was also excellent (89.5 %). Three percent of @entity0 suffered complications during or following surgery and these complications were more frequent with the @entity0 treated by antithrombotic medications. CONCLUSION: This is, in our knowledge, the first prospective study on dermatosurgery activity practised by dermatologists in France. The important rate of participation exemplified the implications of dermatologists in the treatment of @entity1 with an optimal follow-up.

title: [Evaluation of the activity of XXXX 's excision in dermatology (France, 2009)].

answer: @entity1


abstract: A prospective study investigated the effect of local anesthesia, eyelid @entity1 and superior @entity3 on @entity2 . @entity0 were randomized into four groups to study these effects. Group A received a Van Lint eyelid block and a superior rectus bridle suture. Group B received a Van Lint block and an episcleral retraction suture. Group C received a Nadbath @entity5 and a superior rectus bridle suture. Group D received a Nadbath block and an episcleral retraction suture. Results of the study indicate that @entity2 can be significantly reduced by varying our operative techniques. @entity2 was significantly increased in group A and reduced in group D. It appears that @entity4 to the superior rectus muscle complex is the most critical factor in @entity2 . Fifty five and one-half percent of the population entered the study with @entity6 . @entity6 had no effect on @entity2 . Lid crease, superior sulcus fullness and lash rotation are poor anatomical landmarks of levator insertion in the elderly population, both preoperatively and postoperatively.

title: XXXX and cataract surgery. A multivariant computer analysis of a prospective study.

answer: @entity6


abstract: Nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy is an important clinical entity, most commonly encountered in elderly female @entity0 . The expanding use of NSAIDs in the elderly population has led to an increased incidence of NSAID-induced gastropathy. The risk of @entity1 in these @entity0 is 7-fold higher than in the younger population. Long term NSAID therapy in the elderly is apparently associated with failure of normal gastric mucosal adaptation. Silent unidentified @entity3 are likely to be common with long term NSAID therapy, as symptomatology does not parallel pathological progression. This gastropathy, in contrast to peptic @entity2 , is responsive to @entity5 and other cytoprotective agents. A new generation of prostaglandin-sparing NSAIDs (e.g. @entity4 ), in addition to the older nonacetylated salicylates, may represent less gastrotoxic alternatives. Therefore, these agents may substantially reduce the risk of NSAID-induced gastropathy. The debate continues as to whether to use NSAIDs, and under which circumstances. More importantly, the cost-benefit implications and justification for concomitant therapy with gastroprotective agents cloud the picture. Currently, there is a definite consensus that NSAIDs should not be casually used on a chronic basis, especially in @entity0 at risk for serious gastropathy complications. In all cases, where possible, gastric prostaglandin-sparing NSAIDs or nonacetylated salicylates should be used in lowest effective dosages. In special circumstances, gastroprotective co-therapy can be considered. NSAID therapy probably should not be used or continued in elderly @entity0 with a history of bleeding @entity2 or recent major gastric ulcer activity.

title: From peptic XXXX to NSAID gastropathy. An evolving nosology.

answer: @entity2


abstract: C1 and C3 activation, measured as C1r-C1s-C1 inactivator C1s-C1r-C1IA complexes in serum and circulating @entity6 were studied in serial samples from 33 @entity0 with @entity3 . All @entity0 demonstrated exacerbations during observation periods of 10-30 months and were divided into groups according to principal clincal features (mild @entity3 , severe extra-renal @entity3 , and @entity4 ). Increased C1 activation was consistently found during exacerbation. @entity6 in plasma was a feature associated with severe disease flares. Activation of C1, but not of C3, was documented before flare-ups of disease activity, but such predictive information was mostly restricted to @entity0 with @entity1 . C2 cleavage in plasma, studied serially in a few @entity0 , appeared to be closely associated with C1 activation. Circulating immune complexes, measured with solid-phase @entity5 assay, did not always increase before development of clinical manifestations. Remission of symptoms was paralleled by decreasing concentrations of C1r-C1s-C1IA and of, when present, @entity6 . Similar findings were made for immune complexes but only in severe disease. Persisting @entity6 was observed in 3 @entity0 , who subsequently developed @entity2 . @entity5 levels were transiently low during flare-ups of @entity4 , but otherwise the concentrations of @entity5 , C4 and C3 did not show consistent patterns of variation in relation to disease activity.

title: Sequential studies of complement activation in XXXX .

answer: @entity3


abstract: The coexistence of @entity9 ( @entity9 ) and @entity6 is rare. We describe 2 female @entity0 with this combination. A 48-year-old @entity0 presented with @entity10 due to a left @entity8 . Her past history revealed over the previous 3 years the development of @entity3 , @entity7 , @entity11 , @entity12 and @entity5 . Four months prior to this hospitalization, the @entity0 was first admitted due to @entity13 . At that time, laboratory tests revealed an elevated sedimentation rate, elevated titers of ANA and anti-DNA. Chest X-ray demonstrated a widened mediastinum, and upon operation an encapsulated @entity6 was excised. Four months following the thymectomy, the @entity0 is unresponsive despite high dose @entity2 therapy. Another @entity0 , a 30-year-old @entity0 , presented with @entity9 (cutaneous, @entity4 , @entity3 , positive ANA and high titers of anti-DNA) and @entity6 simultaneously. Six years after thymectomy the @entity0 is in @entity9 remission. Thymectomy in @entity1 prone to autoimmunity (NZB/W @entity1 ) has been shown to accelerate the autoimmune manifestations. Conversely, the opposite effect is seen in MRL/lpr @entity1 . The immunological effect of adult thymectomy on the course of @entity0 @entity9 remains to be established, on a larger series of @entity0 . It seems that the heterogenicity of @entity0 @entity0 is exemplified by the contrasting effects of thymectomy for @entity6 in @entity9 @entity0 .

title: XXXX and @entity6 --a double-edged sword.

answer: @entity9


abstract: The coexistence of @entity9 ( @entity9 ) and @entity6 is rare. We describe 2 female @entity0 with this combination. A 48-year-old @entity0 presented with @entity10 due to a left @entity8 . Her past history revealed over the previous 3 years the development of @entity3 , @entity7 , @entity11 , @entity12 and @entity5 . Four months prior to this hospitalization, the @entity0 was first admitted due to @entity13 . At that time, laboratory tests revealed an elevated sedimentation rate, elevated titers of ANA and anti-DNA. Chest X-ray demonstrated a widened mediastinum, and upon operation an encapsulated @entity6 was excised. Four months following the thymectomy, the @entity0 is unresponsive despite high dose @entity2 therapy. Another @entity0 , a 30-year-old @entity0 , presented with @entity9 (cutaneous, @entity4 , @entity3 , positive ANA and high titers of anti-DNA) and @entity6 simultaneously. Six years after thymectomy the @entity0 is in @entity9 remission. Thymectomy in @entity1 prone to autoimmunity (NZB/W @entity1 ) has been shown to accelerate the autoimmune manifestations. Conversely, the opposite effect is seen in MRL/lpr @entity1 . The immunological effect of adult thymectomy on the course of @entity0 @entity9 remains to be established, on a larger series of @entity0 . It seems that the heterogenicity of @entity0 @entity0 is exemplified by the contrasting effects of thymectomy for @entity6 in @entity9 @entity0 .

title: @entity9 and XXXX --a double-edged sword.

answer: @entity6


abstract: The clinical features and treatment of @entity4 in eight @entity0 (four male and four female) less than 2 months of age are presented. @entity4 was noted during the first week of life in six of the @entity0 and between 6 and 8 weeks of life in the other two @entity0 . Four of the eight @entity0 had associated structural or functional @entity1 , and in three @entity0 a central venous pressure catheter was present in the atrium at the time @entity4 was diagnosed. Classic flutter waves were apparent on 12-lead ECGs in only two @entity0 . In six @entity0 , flutter waves were not obvious on standard ECGs, but transesophageal electrogram recordings demonstrated the presence of @entity4 with second degree @entity3 . The atrial cycle length during flutter ranged from 135 to 180 ms (mean 149 ms; mean atrial rate 403 beats per minute); there was a 2:1 ventricular response to @entity4 . Successful termination of @entity4 was accomplished using three modes of electrical cardioversion in seven of the eight @entity0 : direct current cardioversion in one, transvenous atrial pacing in one, and transesophageal atrial pacing in five. One asymptomatic @entity0 converted to normal sinus rhythm 24 hours following digoxin administration. One @entity0 had multiple @entity4 and required chronic @entity5 therapy. In seven of the eight @entity0 , no recurrences have been noted in 6 months to 3 1/2 years of follow-up. These results demonstrate that @entity4 may be difficult to diagnose in @entity0 with @entity2 unless transesophageal electrogram recording is utilized for evaluation.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX in infancy: diagnosis, clinical features, and treatment.

answer: @entity4


abstract: Spatial alterations in blood flow during the development of @entity5 induced by @entity1 -reperfusion in @entity0 were determined with a two-dimensional laser Doppler tissue perfusion imager. The @entity0 were anesthetized with @entity6 , and the stomach was exteriorized on a stage; the mucosa was then sequentially scanned. The mucosa was constantly superfused with 0.1 N @entity7 in physiological saline. Systemic arterial pressure was continuously monitored and blood was stepwisely withdrawn from the femoral artery by 20-mmHg stage and then maintained at 20 mmHg for 20 min. The shed blood was reinfused and the stomach was removed 30 min later. Under control conditions, the average perfusion of the forestomach was usually greater than that in the glandular stomach. When systemic blood pressure was stepwisely decreased, the extent of @entity2 perfusion unit was always greater than that in systemic blood pressure, but mucosal perfusion appeared to be uniformly decreased throughout the stomach. Ten min after reperfusion, a hypoperfused area began to appear in the corpus near the greater curvature, and this area subsequently increased. The area of @entity3 formation corresponded with the hypoperfused area in the gastric mucosa 30 min after reperfusion. Pretreatment with @entity8 , a platelet-activating factor antagonist, significantly attenuated the hypoperfusion induced by reperfusion and also prevented @entity4 . Our results suggest that hypoperfusion in the mucosal microcirculation is indeed an important factor contributing to the localized occurrence of @entity5 and that the laser Doppler perfusion imager is useful for the detection of local hypoperfused areas in the gastric mucosa.

title: Spatial heterogeneity of mucosal blood flow during XXXX -reperfusion injury of @entity0 stomach investigated by laser Doppler perfusion imaging.

answer: @entity1


abstract: Spatial alterations in blood flow during the development of @entity5 induced by @entity1 -reperfusion in @entity0 were determined with a two-dimensional laser Doppler tissue perfusion imager. The @entity0 were anesthetized with @entity6 , and the stomach was exteriorized on a stage; the mucosa was then sequentially scanned. The mucosa was constantly superfused with 0.1 N @entity7 in physiological saline. Systemic arterial pressure was continuously monitored and blood was stepwisely withdrawn from the femoral artery by 20-mmHg stage and then maintained at 20 mmHg for 20 min. The shed blood was reinfused and the stomach was removed 30 min later. Under control conditions, the average perfusion of the forestomach was usually greater than that in the glandular stomach. When systemic blood pressure was stepwisely decreased, the extent of @entity2 perfusion unit was always greater than that in systemic blood pressure, but mucosal perfusion appeared to be uniformly decreased throughout the stomach. Ten min after reperfusion, a hypoperfused area began to appear in the corpus near the greater curvature, and this area subsequently increased. The area of @entity3 formation corresponded with the hypoperfused area in the gastric mucosa 30 min after reperfusion. Pretreatment with @entity8 , a platelet-activating factor antagonist, significantly attenuated the hypoperfusion induced by reperfusion and also prevented @entity4 . Our results suggest that hypoperfusion in the mucosal microcirculation is indeed an important factor contributing to the localized occurrence of @entity5 and that the laser Doppler perfusion imager is useful for the detection of local hypoperfused areas in the gastric mucosa.

title: Spatial heterogeneity of mucosal blood flow during @entity1 -reperfusion injury of XXXX stomach investigated by laser Doppler perfusion imaging.

answer: @entity0


abstract: 1. The effects of the anticonvulsant, @entity8 , have been examined on @entity4 ( @entity2 ) receptor-mediated population spikes in the @entity6 region of the @entity0 hippocampus in vitro. 2. The 'conventional' ( @entity1 receptor-mediated) @entity6 population spike, evoked by electrical stimulation of the Schaffer collateral/commissural pathway, was abolished by 5 min treatment with 5 x 10(-6) M @entity3 ( @entity3 ), after which superfusion with a nominally @entity5 -free Krebs solution (containing 5 x 10(-6) M CNQX) led to the appearance of an epileptiform population spike which was fully developed by 30-40 min. 3. The epileptiform population spike was abolished by the non-competitive @entity2 antagonist, @entity9 (1 x 10(-6) M, 20-30 min) and inhibited by the competitive @entity2 receptor antagonist, @entity11 (IC50 for reducing the amplitude of the first spike in the train = 8.3 x 10(-7) M), demonstrating that the response was mediated by activation of @entity2 receptors and validating its use as an assay for antagonists acting at the @entity2 receptor/channel complex. 4. @entity8 (0.1, 0.3 and 1 x 10(-4) M applied cumulatively for 30 min at each concentration) failed to inhibit the @entity2 receptor-mediated epileptiform population response (n = 7 slices). 5. @entity8 (3 x 10-6 M to 1 x 10-4M) attenuated the effects of the @entity7 channel activator, @entity10 (2 x 10-6 M), on the CAl population spike amplitude (recorded in normal Krebs solution),indicating that the previously observed lack of effect of @entity8 on the @entity2 receptor-mediated response was not due to impaired access of @entity8 to the biophase.6. These data support the conclusion that antagonism of @entity2 receptor-mediated events is not a pharmacological property of @entity8 and that such an action is therefore unlikely to contribute to the anticonvulsant activity of this drug.

title: Electrophysiological actions of @entity8 on XXXX receptor-mediated responses in @entity0 hippocampus in vitro.

answer: @entity4


abstract: 1. The effects of the anticonvulsant, @entity8 , have been examined on @entity4 ( @entity2 ) receptor-mediated population spikes in the @entity6 region of the @entity0 hippocampus in vitro. 2. The 'conventional' ( @entity1 receptor-mediated) @entity6 population spike, evoked by electrical stimulation of the Schaffer collateral/commissural pathway, was abolished by 5 min treatment with 5 x 10(-6) M @entity3 ( @entity3 ), after which superfusion with a nominally @entity5 -free Krebs solution (containing 5 x 10(-6) M CNQX) led to the appearance of an epileptiform population spike which was fully developed by 30-40 min. 3. The epileptiform population spike was abolished by the non-competitive @entity2 antagonist, @entity9 (1 x 10(-6) M, 20-30 min) and inhibited by the competitive @entity2 receptor antagonist, @entity11 (IC50 for reducing the amplitude of the first spike in the train = 8.3 x 10(-7) M), demonstrating that the response was mediated by activation of @entity2 receptors and validating its use as an assay for antagonists acting at the @entity2 receptor/channel complex. 4. @entity8 (0.1, 0.3 and 1 x 10(-4) M applied cumulatively for 30 min at each concentration) failed to inhibit the @entity2 receptor-mediated epileptiform population response (n = 7 slices). 5. @entity8 (3 x 10-6 M to 1 x 10-4M) attenuated the effects of the @entity7 channel activator, @entity10 (2 x 10-6 M), on the CAl population spike amplitude (recorded in normal Krebs solution),indicating that the previously observed lack of effect of @entity8 on the @entity2 receptor-mediated response was not due to impaired access of @entity8 to the biophase.6. These data support the conclusion that antagonism of @entity2 receptor-mediated events is not a pharmacological property of @entity8 and that such an action is therefore unlikely to contribute to the anticonvulsant activity of this drug.

title: Electrophysiological actions of XXXX on @entity4 receptor-mediated responses in @entity0 hippocampus in vitro.

answer: @entity8


abstract: 1. The effects of the anticonvulsant, @entity8 , have been examined on @entity4 ( @entity2 ) receptor-mediated population spikes in the @entity6 region of the @entity0 hippocampus in vitro. 2. The 'conventional' ( @entity1 receptor-mediated) @entity6 population spike, evoked by electrical stimulation of the Schaffer collateral/commissural pathway, was abolished by 5 min treatment with 5 x 10(-6) M @entity3 ( @entity3 ), after which superfusion with a nominally @entity5 -free Krebs solution (containing 5 x 10(-6) M CNQX) led to the appearance of an epileptiform population spike which was fully developed by 30-40 min. 3. The epileptiform population spike was abolished by the non-competitive @entity2 antagonist, @entity9 (1 x 10(-6) M, 20-30 min) and inhibited by the competitive @entity2 receptor antagonist, @entity11 (IC50 for reducing the amplitude of the first spike in the train = 8.3 x 10(-7) M), demonstrating that the response was mediated by activation of @entity2 receptors and validating its use as an assay for antagonists acting at the @entity2 receptor/channel complex. 4. @entity8 (0.1, 0.3 and 1 x 10(-4) M applied cumulatively for 30 min at each concentration) failed to inhibit the @entity2 receptor-mediated epileptiform population response (n = 7 slices). 5. @entity8 (3 x 10-6 M to 1 x 10-4M) attenuated the effects of the @entity7 channel activator, @entity10 (2 x 10-6 M), on the CAl population spike amplitude (recorded in normal Krebs solution),indicating that the previously observed lack of effect of @entity8 on the @entity2 receptor-mediated response was not due to impaired access of @entity8 to the biophase.6. These data support the conclusion that antagonism of @entity2 receptor-mediated events is not a pharmacological property of @entity8 and that such an action is therefore unlikely to contribute to the anticonvulsant activity of this drug.

title: Electrophysiological actions of @entity8 on @entity4 receptor-mediated responses in XXXX hippocampus in vitro.

answer: @entity0


abstract: OBJECTIVE: To determine the localization of the anti- @entity3 mucin monoclonal antibody (mAb) NCRC48 to @entity2 following intravesical administration. @entity0 AND METHODS: mAb NCRC48 (330-500 micrograms) radiolabelled with 111indium (11-17 MBq) was administered intravesically to 12 unselected @entity0 with radiological evidence of @entity2 . Tumour localization was assessed by gamma-camera imaging and by tissue biodistribution studies on biopsies obtained at cystoscopy at about 2 or 24 h after the procedure. After 24 h, whole blood radioactivity was measured and 3 weeks after the procedure the serum level of human anti-mouse antibodies was estimated using an ELISA method. RESULTS: Eleven @entity0 had @entity1 confirmed at cystoscopy (grades 1-3, stages pTa-pT2). The mean uptake of NCRC48 by @entity1 and by normal urothelium (expressed as the percentage of the instilled dose/g x 10(3) +/- SD) at 2 h was 3.42 +/- 3.68 and 0.41 +/- 0.77 (P < 0.05). After 24 h, the values for @entity1 and normal urothelium were 1.17 +/- 1.18 and 0.17 +/- 0.11, respectively. Areas of increased activity on the scintigrams were consistent with the position of the @entity1 at cystoscopy. No radioactivity was detected in blood at 24 h and there was no evidence of a human anti-mouse antibody response. CONCLUSION: The @entity3 mucin may be a suitable antigen to study the potential of therapeutic strategies based on monoclonal antibody targeting of superficial @entity2 and may allow the development of more effective agents in the treatment of this condition.

title: Targeting of XXXX with monoclonal antibody NCRC48--a possible approach for intravesical therapy.

answer: @entity2


abstract: Seven @entity0 (five @entity0 and two @entity0 ) with anal @entity1 in whom previous surgery had failed, were treated by bilateral gluteus maximus transposition. All @entity0 were incontinent to solid stool. Previous surgery was postanal repair in four @entity0 and secondary overlapping suture for obstetric tear in one. The two @entity0 were treated in childhood for anal @entity2 . No covering stoma was used. @entity3 occurred in three @entity0 , requiring surgical drainage in two. After follow-up of more than 1 year three @entity0 experienced improved continence but in four continence was unchanged. Anorectal physiology studies showed moderately increased resting and squeeze pressures in @entity0 who were improved by the operation, but none could retain more than 200 ml of viscous fluid instilled into the rectum. No change in rectal sensitivity or volume tolerance was found. This preliminary series does not indicate that better results are obtained by gluteus maximus transposition than by unstimulated graciloplasty.

title: Bilateral gluteus maximus transposition for anal XXXX .

answer: @entity1


abstract: 1. The effects of sympathetic stimulation and close arterial injection of @entity3 were tested on cutaneous myelinated-fiber (A delta) mechanical nociceptors [high-threshold mechanoreceptors-(MyHTMs)] from normal and from partially transsected nerves. 2. Neither sympathetic stimulation nor close arterial injection of @entity3 (200 ng) excited MyHTMs (18) recorded from the uninjured great auricular nerve of adult @entity0 . 3. MyHTMs (58) conducting across the site of partial cut lesions, made 2 to 28 days previously, had threshold and responsiveness to mechanical stimuli, receptive field organization, and absence of background discharge typical of such elements in normal nerve. 4. Four MyHTMs recorded from the injured nerves were excited by sympathetic stimulation and/or @entity3 injection but only one gave more than two impulses within 60 s to either form of stimulation. 5. The meagerness of the sympathetic and adrenergic excitation of MyHTMs after @entity1 contrasts with that observed under similar conditions for @entity4 polymodal nociceptors. Therefore, induction of adrenergic responsiveness in nociceptors after partial denervation in cutaneous MyHTMs appears to be less important for mechanisms related to pathogenic @entity2 than alterations in certain @entity4 nociceptors.

title: Effects of XXXX on sympathetic excitation of A delta mechanical nociceptors.

answer: @entity1


abstract: Enrichment of lipoproteins with @entity6 derived from animal and/or plant fats may modify the oxidizability of lipoproteins and their effects on endothelial barrier function. To test this hypothesis, @entity0 were fed for 30 days diets containing 2 g @entity7 oil/100 g diet (low fat diet) or low fat supplemented with 16 g/100 g diet of @entity7 oil, @entity7 oil with added @entity1 , milk fat, @entity5 fat, beef tallow or lard. Compared with those fed the low fat, serum and LDL @entity1 concentrations were significantly lower in @entity0 fed @entity7 oil and greater in animals fed @entity7 oil with added @entity1 or @entity5 fat. In contrast to the @entity1 data, lipid @entity3 levels were highest in oxidized LDL derived from @entity0 fed @entity7 oil or lard. LDL @entity2 levels were highest in @entity0 fed @entity7 oil with added @entity1 . The significant elevations in @entity8 [18:2(n-6)] in serum and LDL may partially explain the high oxidizability of LDL in @entity0 fed @entity7 oil. LDL isolated from animals fed @entity7 oil, lard or milk fat had significantly greater albumin transfer across cultured endothelial monolayers compared with those of the low fat diet group. Their oxidative modification further contributed to endothelial barrier dysfunction. Dietary @entity1 supplementation to the @entity7 oil diet decreased oxidizability of LDL and partially protected the oxidized LDL-mediated endothelial cell dysfunction as compared with the @entity7 oil diet group. These data suggest that beef tallow and @entity5 fat are the least atherogenic fats if oxidative modification of LDL is a critical issue in @entity4 .

title: Animal and plant fats selectively modulate oxidizability of XXXX LDL and LDL-mediated disruption of endothelial barrier function.

answer: @entity0


abstract: Resistance and flow across compliant coronary stenoses may be altered by changes in intraluminal pressure. The effects of a distal circumflex @entity2 on a proximal compliant circumflex @entity1 were evaluated in 17 open-chest @entity0 . In ten @entity0 , both stenoses were produced with external snares. As the distal @entity1 was tightened, a point was reached at which flow through the circumflex coronary artery paradoxically increased (8 +/- 1 to 11 +/- 1 ml/min; p less than 0.001). At the point of flow increase, there was an increase in intraluminal pressure between the stenoses (35 +/- 4 to 61 +/- 5 mmHg; p less than 0.001), and a decrease in pressure gradient (69 +/- 5 to 43 +/- 4 mmHg; p less than 0.001) and resistance (10.5 +/- 2.7 to 4.7 +/- 0.8 units; p less than 0.025) across the proximal @entity1 . A similar increase in circumflex blood flow was found in @entity0 in which the @entity1 was produced with an intraluminal balloon. In six additional @entity0 in which the proximal @entity1 was produced with fixed noncompliant plastic tubing, tightening the distal snare did not result in an increase in circumflex blood flow. Thus, the increase in flow occurred only when the proximal @entity1 was compliant. Increasing the severity of the distal @entity1 caused an increase in intraluminal pressure in the area of the proximal @entity1 and may have passively distended the compliant proximal @entity1 decreasing its severity. Therefore, in the presence of compliant coronary stenoses in series, increasing severity of the distal @entity1 may cause a paradoxical increase in flow through the stenotic artery.

title: Interaction of compliant coronary stenoses in series in a XXXX model.

answer: @entity0


abstract: Using the @entity3 @entity3 as a model system, we have investigated the effects of potential neuromodulators on freely behaving animals. Of interest is the modulatory effect of a number of drugs on three rhythmic behaviors of the @entity3 : courtship display (CD) of the male crab, sideways swimming and backward swimming. The drugs tested were @entity5 , @entity1 , @entity4 , @entity0 , and @entity2 . Injection of each drug elicited a unique posture or combination of limb movements. These experiments showed two results pertinent to CD behavior: A posture identical to the CD posture was displayed after @entity1 injection; and rhythmic leg waving similar to CD was evoked by @entity5 . An unusual combination of flexion and extension of all limbs and movements of some limbs occurred after @entity0 injection. Injection of @entity4 led to a posture antagonistic to CD posture. The effects of these drugs were concentration- and time-dependent. Injection of @entity1 , @entity4 , or @entity0 produced effects that were seasonally-dependent, and the influence of @entity5 proved to be dependent on developmental stage. Quantitative analysis of leg waving movements after @entity5 injection allowed for comparison of these movements to naturally-occurring behavior.

title: Modulation of behavior by biogenic amines and peptides in the XXXX , @entity3 .

answer: @entity3


abstract: Using the @entity3 @entity3 as a model system, we have investigated the effects of potential neuromodulators on freely behaving animals. Of interest is the modulatory effect of a number of drugs on three rhythmic behaviors of the @entity3 : courtship display (CD) of the male crab, sideways swimming and backward swimming. The drugs tested were @entity5 , @entity1 , @entity4 , @entity0 , and @entity2 . Injection of each drug elicited a unique posture or combination of limb movements. These experiments showed two results pertinent to CD behavior: A posture identical to the CD posture was displayed after @entity1 injection; and rhythmic leg waving similar to CD was evoked by @entity5 . An unusual combination of flexion and extension of all limbs and movements of some limbs occurred after @entity0 injection. Injection of @entity4 led to a posture antagonistic to CD posture. The effects of these drugs were concentration- and time-dependent. Injection of @entity1 , @entity4 , or @entity0 produced effects that were seasonally-dependent, and the influence of @entity5 proved to be dependent on developmental stage. Quantitative analysis of leg waving movements after @entity5 injection allowed for comparison of these movements to naturally-occurring behavior.

title: Modulation of behavior by biogenic amines and peptides in the @entity3 , XXXX .

answer: @entity3


abstract: OBJECTIVE: The aim of the present study is to investigate the possible clinical and symptomatological determinants of social outcome in @entity2 @entity0 . METHOD: 40 @entity2 @entity0 (DSMIII-R), 21 males and 19 females, mean age 4 +/- 5 years, have been evaluated in the present retrospective study. All of them had first undergone @entity1 hospitalization between 1978 and 1981. The following data have been collected: socio-anagraphic features and course of the @entity3 (AMDP), contacts with community health centre and pharmacological compliance. @entity4 has been investigated by means of a semi-structured interview developed from the "Disability Assessment Schedule" named "Accertamento Disabilit   e Carico Familiare" (ADC), which has been administered to the main carer, usually a cohabitant relative. Presence and level of social support have also been evaluated. One Way Analysis of Variance (ANOVA), "t" test with Bonferroni correction and Pearson Correlation test have been used for data analysis. RESULTS: @entity0 with less severe @entity4 (lower scores at ADC) were mainly those with recurrent @entity3 without residual symptoms or remitted ones (p = 0.0001), better pharmacological compliance (p = 0.004), more frequent and regular contacts with community health centres (p = 0.0001) and better social support (p = 0.01). On the contrary, score at ADC resulted positively correlated with number of hospitalizations (r = 0.57, p = 0.01), number of compulsory admission (r = 0.32, p = 0.01) and length of @entity3 (r = 0.40, p = 0.01). CONCLUSIONS: Although in our study the influence of severity of @entity3 on @entity4 has been confirmed, suggestive evidence about importance of other factors, such as compliance or social support, may be drawn.

title: [Clinical course and social outcome in XXXX . Results from a retrospective study].

answer: @entity2


abstract: @entity3 in the adult disrupts cellular function, resulting in a redistribution of fluids and electrolytes. There is little data about the effects of @entity3 on body fluids in the neonate. The purpose of this study was to determine the effects of @entity3 on cardiovascular function, coronary blood flow, @entity5 ( @entity5 ), plasma volume (PV), and extracellular fluid (ECF) volume in newborn @entity0 . Group 1 consisted of 88 @entity0 , 1-20 days old, and group 2 was 81 @entity0 , 3-6 wk old. There is a significantly higher ECF volume in younger (256 +/- 10 ml/kg) compared with older puppies (121 +/- 5 ml/kg). A 40% @entity3 caused ECF to fall less in the younger (-27%) than in the older puppies (-51%), whereas PV and @entity5 decreased to a similar extent in both groups. After returning shed blood, PV and @entity5 returned to prehemorrhage values, but there was a 12% deficit in functional ECF volume in both groups. A similar degree of @entity4 , @entity1 , and @entity2 occurred in both groups during shock and after returning shed blood. Cardiac output and coronary blood flow, measured only in group 2, fell significantly in shock (-60 and -50%, respectively; P less than 0.05) and remained below control values after returning shed blood. Our data indicate that inadequate perfusion of the myocardium and persistent @entity2 impairs cardiac function in newborn shock.

title: Cardiovascular function and fluid compartments in newborn @entity0 XXXX .

answer: @entity3


abstract: @entity3 in the adult disrupts cellular function, resulting in a redistribution of fluids and electrolytes. There is little data about the effects of @entity3 on body fluids in the neonate. The purpose of this study was to determine the effects of @entity3 on cardiovascular function, coronary blood flow, @entity5 ( @entity5 ), plasma volume (PV), and extracellular fluid (ECF) volume in newborn @entity0 . Group 1 consisted of 88 @entity0 , 1-20 days old, and group 2 was 81 @entity0 , 3-6 wk old. There is a significantly higher ECF volume in younger (256 +/- 10 ml/kg) compared with older puppies (121 +/- 5 ml/kg). A 40% @entity3 caused ECF to fall less in the younger (-27%) than in the older puppies (-51%), whereas PV and @entity5 decreased to a similar extent in both groups. After returning shed blood, PV and @entity5 returned to prehemorrhage values, but there was a 12% deficit in functional ECF volume in both groups. A similar degree of @entity4 , @entity1 , and @entity2 occurred in both groups during shock and after returning shed blood. Cardiac output and coronary blood flow, measured only in group 2, fell significantly in shock (-60 and -50%, respectively; P less than 0.05) and remained below control values after returning shed blood. Our data indicate that inadequate perfusion of the myocardium and persistent @entity2 impairs cardiac function in newborn shock.

title: Cardiovascular function and fluid compartments in newborn XXXX @entity3 .

answer: @entity0


abstract: OBJECTIVE: Usually, physicians base their practice on guidelines, but recommendations on the same topic may vary across guidelines. Given the uncertainties regarding @entity1 ( @entity1 ) screening, physicians should be able to identify systematically and transparently developed recommendations. We performed a systematic review of @entity1 screening guidelines to assist physicians in their choice of recommendations. METHODS: Guidelines in English published between January 1, 2003 and February 26, 2010 were retrieved using MEDLINE, CINAHL, the National Guideline Clearinghouse, the National Library for Health, the Canadian Medication Association Infobase, and the G-I-N International Guideline Library. Guidelines developed by national and international medical societies from Western countries, containing recommendations on @entity1 screening were included. Three reviewers independently assessed rigor of guideline development using the Appraisal of Guidelines Research and Evaluation (AGREE) instrument. Two independent reviewers performed extraction of recommendations. RESULTS: Of 2415 titles identified, seven guidelines were included in this review. Three guidelines were less rigorously developed based on AGREE scores below 40%. All seven guidelines contained a recommendation for one-time screening of elderly @entity0 by ultrasonography to select AAAs >=  5.5 cm for elective surgical repair. Four guidelines, of which three were less rigorously developed, contained disparate recommendations on screening of @entity0 and middle-aged @entity0 at elevated risk. There was no agreement on the management of smaller AAAs. CONCLUSIONS: Consensus exists across guidelines on one-time screening of elderly @entity0 to detect and treat AAAs >=  5.5 cm. For other target groups and management of small AAAs, prediction models and cost-effectiveness analyses are needed to provide guidance.

title: Systematic review of guidelines on XXXX .

answer: @entity1