abstract: Administration of @entity3 ( @entity4 ) to neonatal @entity1 causes a high incidence of @entity2 comparable to @entity2 in @entity0 who were exposed to @entity4 in utero. In the present study, scanning electron microscopy was used to investigate morphological events that might be involved in the development of @entity2 . The effects of @entity4 on luminal epithelia of neonatal @entity1 uterus, vaginal canal, and vaginal fornix were compared with the effects of the drug on those tissues of the adult @entity1 . BALB/c @entity1 were given five s.c. injections of 2 micrograms @entity4 in @entity5 oil or of @entity5 oil alone (controls) on postnatal Days 1 through 5 and were killed on Day 7. Ovariectomized adult BALB/c @entity1 were given s.c. injections of 2 or 20 micrograms @entity4 or of oil on 5 consecutive days and were killed 2 days after the last injections. In neonatal and adult uteri, @entity4 stimulated the growth of microvilli on epithelial cells. The numbers of long and intermediate-length microvilli were markedly increased relative to those in control uteri. @entity4 caused epithelial cornification in all samples of adult vaginal canal and fornix and in three of eleven Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, en Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, en Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, the response of neonatal fornicovaginal epithelium to @entity4 resembled that of neonatal and adult uterine epithelium more than it resembled the response of adult fornicovaginal epithelium; the uterine-like response might be causally related to the development of @entity2 .

title: Morphological effects of XXXX on neonatal @entity1 uterus and vagina.

answer: @entity3


abstract: Administration of @entity3 ( @entity4 ) to neonatal @entity1 causes a high incidence of @entity2 comparable to @entity2 in @entity0 who were exposed to @entity4 in utero. In the present study, scanning electron microscopy was used to investigate morphological events that might be involved in the development of @entity2 . The effects of @entity4 on luminal epithelia of neonatal @entity1 uterus, vaginal canal, and vaginal fornix were compared with the effects of the drug on those tissues of the adult @entity1 . BALB/c @entity1 were given five s.c. injections of 2 micrograms @entity4 in @entity5 oil or of @entity5 oil alone (controls) on postnatal Days 1 through 5 and were killed on Day 7. Ovariectomized adult BALB/c @entity1 were given s.c. injections of 2 or 20 micrograms @entity4 or of oil on 5 consecutive days and were killed 2 days after the last injections. In neonatal and adult uteri, @entity4 stimulated the growth of microvilli on epithelial cells. The numbers of long and intermediate-length microvilli were markedly increased relative to those in control uteri. @entity4 caused epithelial cornification in all samples of adult vaginal canal and fornix and in three of eleven Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, en Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, en Day 7 vaginal canal samples, but not in the remaining eight Day 7 vaginal canal samples or in any of ten Day 7 fornix samples. In the latter tissues, @entity4 caused a marked increase in numbers of short, long, and intermediate-length microvilli on the apical surfaces of epithelial cells. Thus, in the majority of cases, the response of neonatal fornicovaginal epithelium to @entity4 resembled that of neonatal and adult uterine epithelium more than it resembled the response of adult fornicovaginal epithelium; the uterine-like response might be causally related to the development of @entity2 .

title: Morphological effects of @entity3 on neonatal XXXX uterus and vagina.

answer: @entity1


abstract: OBJECTIVE: To present power stapes, stapedotomy, and middle ear implantation with Vibrant SoundBridge (VSB) performed in a one-step surgery as an alternative option for hearing rehabilitation in @entity0 with @entity4 ( @entity4 ). STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral ear center. @entity0 : A family with genetically proven @entity4 Type I. INTERVENTIONS: Two @entity0 , mother and son, with severe to profound mixed @entity2 underwent 3 power stapes, 1 unilateral and 1 bilateral sequential. MAIN OUTCOME MEASURES: Thorough audiological diagnostic batteries including aided and unaided pure-tone and free-field audiometry and Freiburg monosyllabic word test were used to assess the preoperative status and the postoperative hearing outcome. High-resolution computed tomography of the temporal bones was performed as well. Surgical procedure and any special considerations were analyzed in detail. RESULTS: The hearing outcome was favorable in all cases, showing in comparison to the preoperative values an average improvement of 36.8 dB. Severe @entity3 of the middle ear mucosa was the only complication and could be easily controlled by allowing short time intervals. @entity1 did not occur in any case. CONCLUSION: Power stapes represents a safe and promising procedure for treating @entity2 in selected @entity0 with @entity4 . Furthermore, it introduces a new, advantageous VSB application in cases of mixed @entity2 with severe @entity5 and increased bone-conduction thresholds.

title: Power stapes: an alternative method for treating XXXX in @entity4 ?

answer: @entity2


abstract: OBJECTIVE: To present power stapes, stapedotomy, and middle ear implantation with Vibrant SoundBridge (VSB) performed in a one-step surgery as an alternative option for hearing rehabilitation in @entity0 with @entity4 ( @entity4 ). STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral ear center. @entity0 : A family with genetically proven @entity4 Type I. INTERVENTIONS: Two @entity0 , mother and son, with severe to profound mixed @entity2 underwent 3 power stapes, 1 unilateral and 1 bilateral sequential. MAIN OUTCOME MEASURES: Thorough audiological diagnostic batteries including aided and unaided pure-tone and free-field audiometry and Freiburg monosyllabic word test were used to assess the preoperative status and the postoperative hearing outcome. High-resolution computed tomography of the temporal bones was performed as well. Surgical procedure and any special considerations were analyzed in detail. RESULTS: The hearing outcome was favorable in all cases, showing in comparison to the preoperative values an average improvement of 36.8 dB. Severe @entity3 of the middle ear mucosa was the only complication and could be easily controlled by allowing short time intervals. @entity1 did not occur in any case. CONCLUSION: Power stapes represents a safe and promising procedure for treating @entity2 in selected @entity0 with @entity4 . Furthermore, it introduces a new, advantageous VSB application in cases of mixed @entity2 with severe @entity5 and increased bone-conduction thresholds.

title: Power stapes: an alternative method for treating @entity2 in XXXX ?

answer: @entity4


abstract: OBJECTIVE: The objective of this study was to compare demographic and clinical events in three groups of preterm neonates: those with @entity3 ( @entity3 ), those with @entity4 ( @entity4 ) and in preterm @entity0 without NEC. STUDY DESIGN: This retrospective case-control study was conducted at Yale New Haven @entity0 's Hospital using @entity0 data from January 1991 to December 2007. Study @entity0 were less than 36 weeks of gestational age (GA) at birth, without @entity2 . Cases ( @entity3 ) were diagnosed at operation or at autopsy with observation of >80% @entity1 of the GI tract. Two control groups were assigned: Group 1 or @entity4 and Group II or Non-NEC. Two to four controls per case were matched to cases by GA at birth  2 weeks. Demographic and clinical data for the day of diagnosis and retrospectively up to 7 days preceding diagnosis were recorded for those with @entity3 and NEC. Group II controls were matched for date of birth and day of life, in addition to GA at birth. RESULT: A total of 14   075 @entity0 were admitted to the Newborn Special Care Unit during the study interval. Overall 328 @entity0 (2.3%) developed NEC>= Bell's Stage II; 39 @entity0 met inclusion criteria for @entity3 case status; 148 @entity4 and 110 non-NEC controls were assigned. In the comparison of NEC T and @entity4 neonates, use of breast milk was associated with decreased risk of @entity3 , adjusted odds ratio (OR)=0.26, 95% confidence interval (CI) of OR=0.08-0.085, P=0.03. When NEC T and non-NEC @entity0 were compared, having reached full-enteral feeds before the date of diagnosis of the matched case (adjusted OR=28.5, 95% CI of OR=2.7-299, P=0.005) and use of breast milk (adjusted OR=0.09, 95% CI of OR=0.02-0.56, P=0.01) were significantly different between the two groups. CONCLUSION: Breast milk usage was significantly associated with decreased occurrence of @entity3 in our comparison of @entity3 , @entity4 and non-NEC @entity0 . Although there were some differences, the majority of demographic and clinical variables assessed were not shown to be significantly different between cases and controls. This highlights the need for more biological data in assessing risk of developing @entity3 .

title: Risk factors for XXXX : a case-control study.

answer: @entity3


abstract: BACKGROUND: International medical organizations such as the American Society of Medical Oncology recommend early palliative care as the "gold standard" for palliative care in @entity0 with @entity1 . Nevertheless, even in @entity1 , early palliative care is not yet routine practice. The main goal of the @entity2 project is to evaluate whether early palliative care can be implemented-in the sense of "putting evidence into practice"-into the everyday clinical practice of @entity1 . In addition, we are interested in (1) describing the type of support that @entity0 would like from palliative care, (2) gaining information about the effect of palliative care on @entity0 ' quality of life, and (3) understanding the economic burden of palliative care on @entity0 and their families. METHODS/DESIGN: The @entity2 project is a multi-center, prospective cohort study with a sequential control group design. The study is a project of the Palliative Care Center of Excellence (KOMPACT) in Baden-W  rttemberg, Germany, which was recently established to combine the expertise of five academic, specialist palliative care departments. The study is divided into two phases: preliminary phase (months 1-9) and main study phase (months 10-18). In each of all five participating academic @entity1 , an experienced palliative care physician will be hired for 18 months. During the preliminary phase, the physician will be allowed time to establish the necessary structures for early palliative care within the @entity1 Center. In the main study phase, @entity0 with @entity1 will be offered a consultation with the palliative care physician within eight weeks of diagnosis. After the initial consultation, follow-up consultations will be offered as needed. The study is built upon a convergent parallel design. In the quantitative arm, @entity0 will be surveyed in both the preliminary and main study phase at three points in time (baseline, 12 weeks, 24 weeks). Standardized questionnaires will be used to measure @entity0 ' quality of life, symptom burden and mood. Using interviews with palliative care physicians, oncologists, department heads, @entity0 and their caregivers, the qualitative arm will explore (1) what factors encourage and hinder the early integration of palliative care into standard oncology care, (2) what support @entity0 and their caregivers would like from palliative care, and (3) what effect palliative care has on the economic disease burden of @entity0 and their families. DISCUSSION: The study proposed is meant to serve as a catalyzer. Local palliative care teams should be put in position to routinely cooperate with the primary treating department at their respective @entity1 center. The long-term goal of this project is to create sustainable improvements in the care of @entity0 with incurable @entity1 . TRIAL REGISTRATION: DRKS00006162 ; date of registration: 19/05/2014.

title: Early Palliative Care-Health services research and implementation of sustainable changes: the study protocol of the XXXX project.

answer: @entity2


abstract: OBJECTIVES: Randomized clinical trial (RCT) data reviewed for outcomes and processes associated with @entity1 educational and behavioral interventions provided by different types of health professionals. METHODS: Cochrane Collaboration, MEDLINE, PUBMED, Google Scholar search from 1998 to 2009 identified 1650 articles regarding @entity1 educational and behavioral interventions resulting in 249 potential studies and following assessment produced a final sample of 50 RCTs. RESULTS: Approaches, intended outcomes, and program providers vary greatly. No rationale provided in study reports for the selection of specific outcomes, program providers, or program components. Health care utilization and symptom control have been the most common outcomes assessed. Specific providers favor particular teaching approaches. Multidisciplinary teams have been the most frequent providers of @entity1 interventions. Physician-led interventions were most successful for outcomes related to the use of health care. Multidisciplinary teams were best in achieving symptom reduction and quality of life. Lay @entity0 were best in achieving self-management/self-efficacy outcomes. Components most frequently employed in successful programs are skills to improve @entity0 -clinician communication and education to enhance @entity0 self-management. Fifty percent of interventions achieved reduction in the use of health care and one-third in symptom control. A combination approach including self-management and @entity0 -clinician communication involving multidisciplinary team members may have the greatest effect on most outcomes. CONCLUSIONS: The extent to which and how different providers achieve @entity1 outcomes through educational and behavioral interventions is emerging from recent studies. Health care use and symptom control are evolving as the gold standard for intervention outcomes. Development of self-management and clinician- @entity0 communication skills are program components associated with success across outcomes and providers.

title: Educational and behavioral interventions for XXXX : who achieves which outcomes? A systematic review.

answer: @entity1


abstract: UNASSIGNED: In temperate and sub-tropical regions of Asia and Latin America, complicated @entity3 manifested as @entity4 or @entity1 is seen in all age groups. There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated @entity3 in @entity0 , much less is known about it in adults. We report here, the analysis of data from a custom, cross strain microarray (Agilent Platform) using material from adult @entity0 samples, showing @entity4 or @entity2 . These are the most common manifestations seen in adults along with @entity7 . The data has been analyzed with reference to variant surface antigens, encoded by the var, rifin and stevor gene families. The differential regulation profiles of key genes (comparison between @entity5 complicated and uncomplicated isolates) have been observed. The exportome has been analyzed using similar parameters. Gene ontology term based functional enrichment of differentially regulated genes identified, up-regulated genes statistically enriched (P<0.05) to critical biological processes like generation of precursor metabolite and energy, chromosome organization and electron transport chain. Systems network based functional enrichment of overall differentially regulated genes yielded a similar result. We are reporting here, up-regulation of var group B and C genes whose proteins are predicted to interact with @entity6 receptor in the host, the up-regulation of domain cassette 13 (DC13) containing var group A, as also the up-regulation of group A rifins and many of the stevors. This is contrary to most other reports from pediatric @entity0 , with @entity7 where the up-regulation of mostly var A group genes have been seen. A protein-protein interaction based network has been created and analysis performed. This co-expression and text mining based network has shown overall connectivity between the variant surface antigens (VSA) and the exportome. The up-regulation of var group B and C genes encoding PfEMP1 with different domain architecture would be important for deciding strategies for disease prevention.

title: XXXX complicated @entity3 : Modulation and connectivity between exportome and variant surface antigen gene families.

answer: @entity5


abstract: UNASSIGNED: In temperate and sub-tropical regions of Asia and Latin America, complicated @entity3 manifested as @entity4 or @entity1 is seen in all age groups. There has been a concerted focus on understanding the patho-physiological and molecular basis of complicated @entity3 in @entity0 , much less is known about it in adults. We report here, the analysis of data from a custom, cross strain microarray (Agilent Platform) using material from adult @entity0 samples, showing @entity4 or @entity2 . These are the most common manifestations seen in adults along with @entity7 . The data has been analyzed with reference to variant surface antigens, encoded by the var, rifin and stevor gene families. The differential regulation profiles of key genes (comparison between @entity5 complicated and uncomplicated isolates) have been observed. The exportome has been analyzed using similar parameters. Gene ontology term based functional enrichment of differentially regulated genes identified, up-regulated genes statistically enriched (P<0.05) to critical biological processes like generation of precursor metabolite and energy, chromosome organization and electron transport chain. Systems network based functional enrichment of overall differentially regulated genes yielded a similar result. We are reporting here, up-regulation of var group B and C genes whose proteins are predicted to interact with @entity6 receptor in the host, the up-regulation of domain cassette 13 (DC13) containing var group A, as also the up-regulation of group A rifins and many of the stevors. This is contrary to most other reports from pediatric @entity0 , with @entity7 where the up-regulation of mostly var A group genes have been seen. A protein-protein interaction based network has been created and analysis performed. This co-expression and text mining based network has shown overall connectivity between the variant surface antigens (VSA) and the exportome. The up-regulation of var group B and C genes encoding PfEMP1 with different domain architecture would be important for deciding strategies for disease prevention.

title: @entity5 complicated XXXX : Modulation and connectivity between exportome and variant surface antigen gene families.

answer: @entity3


abstract: Multi-gene panels are used to identify genetic causes of @entity3 ( @entity3 ) in large @entity0 cohorts. This study compares the diagnostic workflow in two centers and gives valuable insights into different next-generation sequencing (NGS) strategies. Moreover, we present data from 620 @entity0 sequenced at both centers. Both sequencing centers are part of the German consortium for @entity3 (GC- @entity3 ). All 620 @entity0 included in this study were selected following standard @entity4 /2 testing guidelines. A set of 10 sequenced genes was analyzed per @entity0 . Twelve samples were exchanged and sequenced at both centers. NGS results were highly concordant in 12 exchanged samples (205/206 variants = 99.51 %). One non-pathogenic variant was missed at center B due to a sequencing gap (no technical coverage). The custom enrichment at center B was optimized during this study; for example, the average number of missing bases was reduced by a factor of four (vers. 1: 1939.41, vers. 4: 506.01 bp). There were no sequencing gaps at center A, but four CCDS exons were not included in the enrichment. Pathogenic mutations were found in 12.10 % (75/620) of all @entity0 : 4.84 % (30/620) in @entity4 , 4.35 % in @entity2 (27/620), 0.97 % in @entity6 (6/620), 0.65 % in ATM (4/620), 0.48 % in @entity5 (3/620), 0.32 % in @entity7 (2/620), 0.32 % in NBN (2/620), and 0.16 % in @entity1 (1/620). NGS diagnostics for @entity3 -related genes is robust, cost effective, and the method of choice for genetic testing in large cohorts. Adding 8 genes to standard @entity4 - and @entity2 -testing increased the mutation detection rate by one-third.

title: XXXX multi-gene panel testing: comparison of two sequencing centers.

answer: @entity3


abstract: BACKGROUND: @entity3 after the clipping for an @entity2 are rare. The information on the pathogenesis and treatment options for this condition is largely unknown. CASE DESCRIPTION: An 82-year-old female with no @entity0 underwent a clipping for a @entity1 . Immediately after surgery, she presented with hemichorea-hemiballismus (HC-HB) on the left side. Postoperative angiograms and single-photon emission computed tomography demonstrated the hyperperfusion in the right frontal cortex and the decreased perfusion in the basal ganglia, indicating that the abrupt hemodynamic changes due to the obliteration of the @entity2 caused the dysfunction of the frontal cortical and subcortical pathway and the basal ganglia. Administration of @entity4 was dramatically effective in controlling the HC-HB until the hyperperfusion resolved. Single-photon emission computed tomography obtained 8 weeks after surgery revealed that the cerebral blood flow had been normalized in the right frontal cortex. The relative hypoperfusion of the right basal ganglia was also resolved. Then @entity4 was discontinued without a relapse of HC-HB. CONCLUSION: This case appears consistent with the theory that the connecting fibers responsible for the development of HC-HB are also located in the frontal lobe. The treatment of @entity2 involving the M1 portion can cause abrupt hemodynamic changes in both frontal cortex and the basal ganglia, which can potentially induce postoperative @entity3 .

title: Hemichorea-hemiballismus caused by postoperative hyperperfusion after clipping of a giant unruptured XXXX .

answer: @entity1


abstract: BACKGROUND: It is difficult to intraoperatively confirm the total disappearance of arteriovenous (AV) shunts during surgery for microarteriovenous @entity1 (micro-AVMs), especially when the nidus is extremely small or diffuse on preoperative angiography. Although intraoperative angiography is effective for evaluating residual shunts, procedure-related risks raise important concerns. The purpose of this study was to assess the usefulness of intraoperative @entity3 -based videoangiography (ICG-VA) to determine complete disappearance of micro-AVMs during surgery. METHODS: We retrospectively analyzed eight @entity0 with ruptured micro-AVMs who were treated using craniotomy with ICG-VA at our institution. RESULTS: Two @entity0 underwent emergency partial evacuation of @entity2 and external decompression before the diagnostic angiography. While three @entity0 had a nidus smaller than 1 cm, five @entity0 had only early draining veins without an appreciable nidus. The draining veins were superficial in six cases and deep in two cases. The average interval from onset to surgery was 33 days (range, 2-57). ICG-VA was repetitively conducted until disappearance of the AV shunt was confirmed. No residual AV shunt was observed on postoperative radiological examinations. In all cases, the diagnosis of @entity4 was confirmed from the results of postoperative pathological examination. CONCLUSIONS: ICG-VA could detect early draining veins more clearly in situ than diagnostic angiography. Although it is not as effective for visualizing lesions with deep draining veins, repetitive ICG-VA was safe and effective for confirming the disappearance of AV shunts with superficial drainage.

title: Usefulness of repetitive intraoperative @entity3 -based videoangiography to confirm complete obliteration of micro-arteriovenous XXXX .

answer: @entity1


abstract: BACKGROUND: It is difficult to intraoperatively confirm the total disappearance of arteriovenous (AV) shunts during surgery for microarteriovenous @entity1 (micro-AVMs), especially when the nidus is extremely small or diffuse on preoperative angiography. Although intraoperative angiography is effective for evaluating residual shunts, procedure-related risks raise important concerns. The purpose of this study was to assess the usefulness of intraoperative @entity3 -based videoangiography (ICG-VA) to determine complete disappearance of micro-AVMs during surgery. METHODS: We retrospectively analyzed eight @entity0 with ruptured micro-AVMs who were treated using craniotomy with ICG-VA at our institution. RESULTS: Two @entity0 underwent emergency partial evacuation of @entity2 and external decompression before the diagnostic angiography. While three @entity0 had a nidus smaller than 1 cm, five @entity0 had only early draining veins without an appreciable nidus. The draining veins were superficial in six cases and deep in two cases. The average interval from onset to surgery was 33 days (range, 2-57). ICG-VA was repetitively conducted until disappearance of the AV shunt was confirmed. No residual AV shunt was observed on postoperative radiological examinations. In all cases, the diagnosis of @entity4 was confirmed from the results of postoperative pathological examination. CONCLUSIONS: ICG-VA could detect early draining veins more clearly in situ than diagnostic angiography. Although it is not as effective for visualizing lesions with deep draining veins, repetitive ICG-VA was safe and effective for confirming the disappearance of AV shunts with superficial drainage.

title: Usefulness of repetitive intraoperative XXXX -based videoangiography to confirm complete obliteration of micro-arteriovenous @entity1 .

answer: @entity3


abstract: Candida spp. can lead to @entity1 or even @entity2 particularly among immunocompromised individuals. OBJECTIVE: The aim of the present study was to analyze the presence of Candida spp. among @entity0 subjected to orthotopic heart transplantation. MATERIAL AND METHODS: Oral rinses from 50 @entity0 subjected to orthotopic heart transplantation, aged 13 to 70 years, 40 males and 10 females, were examined. Sex-age-oral conditions matched-control included 50 individuals who were not subjected to any kind of transplantation and were not immunocompromised for any other reason. Counts of @entity3 were expressed as median values of logarithm of cfu/mL and were statistically compared by Mann-Whitney's test. The heart transplant and control groups were compared for the presence of Candida spp. by chi-square test (p<0.05). RESULTS: The results showed statistically significant difference (p=0.001) in the prevalence of Candida spp. between the transplantation and control groups. Counts of @entity3 (cfu/mL) in the transplanted group were significantly higher than in the control group (p=0.005). @entity4 was the most prevalent species isolated from both groups. CONCLUSIONS: It was concluded that Candida @entity3 counts were higher in the heart transplant recipients than in the controls. There was higher variation of Candida species among the heart transplant @entity0 and the most frequently isolated samples were: @entity4 , @entity5 and @entity6 . Isolates of @entity7 was not found in either of the groups.

title: Presence of Candida spp. in the oral cavity of heart transplantation XXXX .

answer: @entity0


abstract: To compare clinical and laboratory findings between @entity0 with @entity11 ( @entity11 ) versus secondary @entity16 due to @entity15 ( @entity16 ) (according to Jones criteria). Seventy-three @entity16 @entity0 (Sapporo criteria) were enrolled, and demographic, clinical, and laboratory data were collected. Exclusion criteria were @entity13 and previous @entity4 . @entity0 were divided into two groups: @entity11 (n  =  68) and @entity16 (n  =  5). The mean current age, disease duration, frequencies of female gender, and Caucasian race were similar in @entity16 and @entity11 @entity0 (P  >  0.05). Remarkably, the frequency of @entity2 was significantly higher in @entity16 compared to @entity11 @entity0 (80% vs. 25%, P  =  0.02). Of note, echocardiogram of these @entity0 did not show @entity6 . No significant differences were found in peripheral @entity9 events (P  =  1.0), @entity10 (P  =  1.0), @entity12 (P  =  0.16), @entity7 (P  =  0.36), arterial events (P  =  0.58), and @entity6 of small vessels (P  =  1.0). There were no differences in the frequencies of comorbidities such as @entity1 , @entity3 , smoking, and @entity5 in both groups (P  >  0.05). The frequencies of @entity14 , IgG, and IgM anticardiolipin were similar in two groups. @entity16 @entity0 associated with @entity15 without @entity8 may imply a high @entity2 risk as compared with @entity11 , and future studies are needed to confirm this finding.

title: @entity11 plus @entity15 : a higher risk factor for XXXX ?

answer: @entity2


abstract: To compare clinical and laboratory findings between @entity0 with @entity11 ( @entity11 ) versus secondary @entity16 due to @entity15 ( @entity16 ) (according to Jones criteria). Seventy-three @entity16 @entity0 (Sapporo criteria) were enrolled, and demographic, clinical, and laboratory data were collected. Exclusion criteria were @entity13 and previous @entity4 . @entity0 were divided into two groups: @entity11 (n  =  68) and @entity16 (n  =  5). The mean current age, disease duration, frequencies of female gender, and Caucasian race were similar in @entity16 and @entity11 @entity0 (P  >  0.05). Remarkably, the frequency of @entity2 was significantly higher in @entity16 compared to @entity11 @entity0 (80% vs. 25%, P  =  0.02). Of note, echocardiogram of these @entity0 did not show @entity6 . No significant differences were found in peripheral @entity9 events (P  =  1.0), @entity10 (P  =  1.0), @entity12 (P  =  0.16), @entity7 (P  =  0.36), arterial events (P  =  0.58), and @entity6 of small vessels (P  =  1.0). There were no differences in the frequencies of comorbidities such as @entity1 , @entity3 , smoking, and @entity5 in both groups (P  >  0.05). The frequencies of @entity14 , IgG, and IgM anticardiolipin were similar in two groups. @entity16 @entity0 associated with @entity15 without @entity8 may imply a high @entity2 risk as compared with @entity11 , and future studies are needed to confirm this finding.

title: XXXX plus @entity15 : a higher risk factor for @entity2 ?

answer: @entity11


abstract: To compare clinical and laboratory findings between @entity0 with @entity11 ( @entity11 ) versus secondary @entity16 due to @entity15 ( @entity16 ) (according to Jones criteria). Seventy-three @entity16 @entity0 (Sapporo criteria) were enrolled, and demographic, clinical, and laboratory data were collected. Exclusion criteria were @entity13 and previous @entity4 . @entity0 were divided into two groups: @entity11 (n  =  68) and @entity16 (n  =  5). The mean current age, disease duration, frequencies of female gender, and Caucasian race were similar in @entity16 and @entity11 @entity0 (P  >  0.05). Remarkably, the frequency of @entity2 was significantly higher in @entity16 compared to @entity11 @entity0 (80% vs. 25%, P  =  0.02). Of note, echocardiogram of these @entity0 did not show @entity6 . No significant differences were found in peripheral @entity9 events (P  =  1.0), @entity10 (P  =  1.0), @entity12 (P  =  0.16), @entity7 (P  =  0.36), arterial events (P  =  0.58), and @entity6 of small vessels (P  =  1.0). There were no differences in the frequencies of comorbidities such as @entity1 , @entity3 , smoking, and @entity5 in both groups (P  >  0.05). The frequencies of @entity14 , IgG, and IgM anticardiolipin were similar in two groups. @entity16 @entity0 associated with @entity15 without @entity8 may imply a high @entity2 risk as compared with @entity11 , and future studies are needed to confirm this finding.

title: @entity11 plus XXXX : a higher risk factor for @entity2 ?

answer: @entity15


abstract: Telomerase mutations and significantly shortened chromosomal @entity5 have recently been implicated in @entity0 lung pathologies. Natural telomere @entity4 is an inevitable consequence of aging, which is also a risk factor for development of @entity2 . However, the impact of shortened @entity3 on the ability of lung cells to respond to significant challenge is still largely unknown. We have previously shown that lungs of late generation, telomerase null B6.Cg- @entity6 (tm1Rdp) @entity1 feature alveolar simplification and chronic stress signaling at baseline, a phenocopy of aged lung. To determine the role telomerase plays when the lung is challenged, B6.Cg- @entity6 (tm1Rdp) @entity1 carrying shortened @entity5 and wild-type controls were subjected to partial pneumonectomy. We found that telomerase activity was strongly induced in alveolar epithelial type 2 cells (AEC2) of the remaining lung immediately following surgery. Eighty-six percent of wild-type animals survived the procedure and exhibited a burst of early compensatory growth marked by upregulation of proliferation, stress response, and DNA repair pathways in AEC2. In B6.Cg- @entity6 (tm1Rdp) @entity1 carrying shortened @entity5 , response to pneumonectomy was characterized by decreased survival, diminished compensatory lung growth, attenuated distal lung progenitor cell response, persistent DNA damage, and cell growth arrest. Overall, survival correlated strongly with telomere length. We conclude that functional telomerase and properly maintained @entity5 play key roles in both long-term survival and the early phase of compensatory lung growth following partial pneumonectomy.

title: Partial pneumonectomy of telomerase null XXXX carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response.

answer: @entity1


abstract: An important step in using culture to increase @entity2 screening is the development and use of a reliable and valid measure. Measurement items that work well are defined as those that use clear and simple language, do not result in significant missing data, do not yield unexpected frequencies or patterns of association, and capture an important component of the underlying construct. The authors' work to develop such a measure includes cognitive response testing. This article describes 41 African American @entity0 ' reactions to and processing of items that have been used in the public health literature to assess cultural attitudes believed to be relevant to @entity2 screening. @entity0 were asked to verbalize thoughts, feelings, interpretations, and ideas that came to mind while examining or responding to 10 to 11 survey items. The results of cognitive response testing suggest negative reactions to items addressing the fatalism construct, concerns about appearing racist when responding to discrimination and mistrust items, and resistance to phrasing or terminology that conveys negative attitudes or frames of reference. When items were framed in a positive way, @entity0 reported less frustration, @entity3 , and concern for how they would be perceived by others. The responses of older African Americans in this sample were consistent with research previously completed by Pasick et al.; @entity0 questioned the relevance of items related to cultural constructs to health and @entity1 preventive behaviors. Recommendations for the assessment and use of cultural constructs and items assessing constructs are provided.

title: Refining the use of XXXX -related cultural constructs with African Americans.

answer: @entity1


abstract: PURPOSE: To compare RPE derived from @entity0 embryonic stem cells (hES-RPE) and fetal RPE (fRPE) behavior on @entity0 Bruch's membrane (BM) from aged and @entity4 donors. METHODS: hES-RPE of 3 degrees of pigmentation and fRPE were cultured on BM explants. Explants were assessed by light, confocal, and scanning electron microscopy. Integrin mRNA levels were determined by real-time polymerase chain reaction studies. Secreted proteins in media were analyzed by multiplex protein analysis after 48-hour exposure at culture day 21. RESULTS: hES-RPE showed impaired initial attachment compared to fRPE; pigmented hES-RPE showed nuclear densities similar to fRPE at day 21. At days 3 and 7, hES-RPE resurfaced BM to a limited degree, showed little proliferation (Ki-67), and partial retention of RPE markers ( @entity3 , cytokeratin, and @entity6 ). TUNEL-positive nuclei were abundant at day 3. fRPE exhibited substantial BM resurfacing at day 3 with decreased resurfacing at later times. Most fRPE retained RPE markers. Ki-67-positive nuclei decreased with time in culture. TUNEL staining was variable. Increased integrin mRNA expression did not appear to affect cell survival at day 21. hES-RPE and fRPE protein secretion was similar on equatorial BM except for higher levels of nerve growth factor and @entity5 ( @entity5 ) by hES-RPE. On submacular BM, fRPE secreted more @entity1 ( @entity1 ), @entity2 , and platelet-derived growth factor; hES-RPE secreted more @entity5 . CONCLUSIONS: Although pigmented hES-RPE and fRPE resurfaced aged and @entity4 BM to a similar, limited degree at day 21, cell behavior at earlier times was markedly dissimilar. Differences in protein secretion may indicate that hES-RPE may not function identically to native RPE after seeding on aged or @entity4 BM.

title: Comparison of FRPE and XXXX embryonic stem cell-derived RPE behavior on aged @entity0 Bruch's membrane.

answer: @entity0


abstract: PURPOSE: To compare RPE derived from @entity0 embryonic stem cells (hES-RPE) and fetal RPE (fRPE) behavior on @entity0 Bruch's membrane (BM) from aged and @entity4 donors. METHODS: hES-RPE of 3 degrees of pigmentation and fRPE were cultured on BM explants. Explants were assessed by light, confocal, and scanning electron microscopy. Integrin mRNA levels were determined by real-time polymerase chain reaction studies. Secreted proteins in media were analyzed by multiplex protein analysis after 48-hour exposure at culture day 21. RESULTS: hES-RPE showed impaired initial attachment compared to fRPE; pigmented hES-RPE showed nuclear densities similar to fRPE at day 21. At days 3 and 7, hES-RPE resurfaced BM to a limited degree, showed little proliferation (Ki-67), and partial retention of RPE markers ( @entity3 , cytokeratin, and @entity6 ). TUNEL-positive nuclei were abundant at day 3. fRPE exhibited substantial BM resurfacing at day 3 with decreased resurfacing at later times. Most fRPE retained RPE markers. Ki-67-positive nuclei decreased with time in culture. TUNEL staining was variable. Increased integrin mRNA expression did not appear to affect cell survival at day 21. hES-RPE and fRPE protein secretion was similar on equatorial BM except for higher levels of nerve growth factor and @entity5 ( @entity5 ) by hES-RPE. On submacular BM, fRPE secreted more @entity1 ( @entity1 ), @entity2 , and platelet-derived growth factor; hES-RPE secreted more @entity5 . CONCLUSIONS: Although pigmented hES-RPE and fRPE resurfaced aged and @entity4 BM to a similar, limited degree at day 21, cell behavior at earlier times was markedly dissimilar. Differences in protein secretion may indicate that hES-RPE may not function identically to native RPE after seeding on aged or @entity4 BM.

title: Comparison of FRPE and @entity0 embryonic stem cell-derived RPE behavior on aged XXXX Bruch's membrane.

answer: @entity0


abstract: The E4 allele of the @entity4 ( @entity4 ) gene has been identified as a major risk factor for the development of late onset @entity2 ( @entity2 ). However, the mechanisms by which this gene affects @entity2 are not fully understood. Studies of @entity4 knock-out ( @entity4 KO) @entity0 have revealed an exacerbation of two major pathologies that are diagnostic of @entity2 : neurofibrillary tangles and senile plaques. However, evidence as to whether these @entity0 have @entity1 is not yet conclusive. This ambiguity may arise partly from confounds associated with reliance on limited memory models, primarily, the Morris water maze task. An 8-arm radial maze task was therefore used to measure spatial memory in the @entity4 KO @entity0 , compared to controls over time. Furthermore, the effectiveness of a combination antioxidant therapy (CAT), designed to slow down the progression of @entity2 based on concepts of oxidative stress and inflammatory processes underlying the pathology, was tested on memory ability. A significant strain difference was observed with the @entity4 KO @entity0 performing better than controls in terms of reference memory and corrects entries. No significant strain difference was observed for performance in terms of working @entity3 . No significant effect of the CAT supplementation was observed.

title: Memory function in a @entity0 genetic model of XXXX .

answer: @entity2


abstract: The E4 allele of the @entity4 ( @entity4 ) gene has been identified as a major risk factor for the development of late onset @entity2 ( @entity2 ). However, the mechanisms by which this gene affects @entity2 are not fully understood. Studies of @entity4 knock-out ( @entity4 KO) @entity0 have revealed an exacerbation of two major pathologies that are diagnostic of @entity2 : neurofibrillary tangles and senile plaques. However, evidence as to whether these @entity0 have @entity1 is not yet conclusive. This ambiguity may arise partly from confounds associated with reliance on limited memory models, primarily, the Morris water maze task. An 8-arm radial maze task was therefore used to measure spatial memory in the @entity4 KO @entity0 , compared to controls over time. Furthermore, the effectiveness of a combination antioxidant therapy (CAT), designed to slow down the progression of @entity2 based on concepts of oxidative stress and inflammatory processes underlying the pathology, was tested on memory ability. A significant strain difference was observed with the @entity4 KO @entity0 performing better than controls in terms of reference memory and corrects entries. No significant strain difference was observed for performance in terms of working @entity3 . No significant effect of the CAT supplementation was observed.

title: Memory function in a XXXX genetic model of @entity2 .

answer: @entity0


abstract: @entity12 is primarily a pneumonic process caused by Legionella pneumophilia, a gram-negative aerobic bacillus but also has multiple system involvement. The most common manifestation is @entity3 suggesting a generalized @entity3 but focal neurological manifestations have been reported. We report a @entity0 with @entity2 associated with @entity4 and unilateral @entity8 . 51-year-old previously healthy male presented with @entity10 , cough, slurred speech, and unsteadiness on feet associated with malaise, fevers and @entity9 . @entity0 's family reported facial asymmetry for 2 days. @entity0 had no significant medical history and was not on any medication. He denied smoking, @entity6 or illicit drug use. Chest X-ray showed bilateral lower lobe infiltrates. Urinary antigen assay for Legionella pneumophilia serogroup 1 was positive. @entity0 was started on intravenous @entity11 . On day 5 the @entity0 was discharged home and continued oral @entity11 for two weeks. After the two weeks, his respiratory symptoms, @entity14 and @entity13 resolved. We report the first case of @entity12 with @entity4 and @entity5 . @entity12 should be considered in @entity0 with any @entity1 in the setting of @entity2 . Failure to recognize and treat the @entity7 may lead to poor outcomes.

title: XXXX with facial nerve palsy.

answer: @entity12


abstract: Endoscopic @entity2 (EPBD) is an alternative method of endoscopic sphincterotomy (EST). Although concerns regarding post-procedure @entity4 have been expressed, EPBD has come to be recognized as an effective and safe method for stone removal in specific cases. To analyze the proper indications, ideal methods, complications, and long-term follow-up results for EPBD, we reviewed articles about EPBD located through a search of the PubMed data base. We analyzed the ballooning methods, indications, results and complications of EPBD among the articles found and compared the results with those of EST. We considered the authors' own clinical experience and knowledge in developing recommendations for EPBD. EPBD showed similar efficacy and safety for the removal of @entity7 to that of EST. Although large or multiple stones were difficult to remove by EPBD, it was safer and easier to apply in @entity0 with @entity5 or abnormal anatomy. To prevent severe @entity4 , @entity3 should be avoided, and precut sphincterotomy or adjuvant prophylaxis should be considered. Due to its preservation of the sphincter of Oddi, EPBD is expected to have fewer long-term complications, such as stone recurrence, @entity1 and @entity6 . In conclusion, EPBD appears to be safe and effective for the treatment of @entity7 with proper selection of ballooning methods and @entity0 .

title: Endoscopic @entity2 for removal of XXXX : indications, advantages, complications, and long-term follow-up results.

answer: @entity7


abstract: Endoscopic @entity2 (EPBD) is an alternative method of endoscopic sphincterotomy (EST). Although concerns regarding post-procedure @entity4 have been expressed, EPBD has come to be recognized as an effective and safe method for stone removal in specific cases. To analyze the proper indications, ideal methods, complications, and long-term follow-up results for EPBD, we reviewed articles about EPBD located through a search of the PubMed data base. We analyzed the ballooning methods, indications, results and complications of EPBD among the articles found and compared the results with those of EST. We considered the authors' own clinical experience and knowledge in developing recommendations for EPBD. EPBD showed similar efficacy and safety for the removal of @entity7 to that of EST. Although large or multiple stones were difficult to remove by EPBD, it was safer and easier to apply in @entity0 with @entity5 or abnormal anatomy. To prevent severe @entity4 , @entity3 should be avoided, and precut sphincterotomy or adjuvant prophylaxis should be considered. Due to its preservation of the sphincter of Oddi, EPBD is expected to have fewer long-term complications, such as stone recurrence, @entity1 and @entity6 . In conclusion, EPBD appears to be safe and effective for the treatment of @entity7 with proper selection of ballooning methods and @entity0 .

title: Endoscopic XXXX for removal of @entity7 : indications, advantages, complications, and long-term follow-up results.

answer: @entity2


abstract: PURPOSE: To investigate the association between @entity3 ( @entity3 ) and serum levels of @entity7 in @entity0 with systemic immune-mediated diseases. METHODS: @entity7 and @entity8 levels were measured in the sera of @entity0 whose tear production was <5 mm on the Schirmer test. Subjects included @entity0 with @entity6 ( @entity6 ), @entity2 ( @entity2 ), @entity9 ( @entity9 ), @entity5 ( @entity5 ), and no @entity1 . Corneal/conjunctival @entity4 staining was scored and the correlation between the score and the @entity7 level was evaluated. RESULTS: A strong correlation existed between @entity7 level and the type of @entity1 . @entity7 was significantly elevated in @entity0 with chronic @entity6 compared to those with @entity2 and @entity9 . @entity7 was not detectable in @entity0 with @entity5 or in those without @entity1 . @entity8 was not detected in any of the subjects. @entity7 was significantly increased in @entity0 with high @entity4 staining scores. CONCLUSIONS: Our data suggest that @entity7 is involved in the pathogenesis of @entity3 in @entity0 with systemic immune-mediated diseases.

title: Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in @entity0 with XXXX .

answer: @entity3


abstract: PURPOSE: To investigate the association between @entity3 ( @entity3 ) and serum levels of @entity7 in @entity0 with systemic immune-mediated diseases. METHODS: @entity7 and @entity8 levels were measured in the sera of @entity0 whose tear production was <5 mm on the Schirmer test. Subjects included @entity0 with @entity6 ( @entity6 ), @entity2 ( @entity2 ), @entity9 ( @entity9 ), @entity5 ( @entity5 ), and no @entity1 . Corneal/conjunctival @entity4 staining was scored and the correlation between the score and the @entity7 level was evaluated. RESULTS: A strong correlation existed between @entity7 level and the type of @entity1 . @entity7 was significantly elevated in @entity0 with chronic @entity6 compared to those with @entity2 and @entity9 . @entity7 was not detectable in @entity0 with @entity5 or in those without @entity1 . @entity8 was not detected in any of the subjects. @entity7 was significantly increased in @entity0 with high @entity4 staining scores. CONCLUSIONS: Our data suggest that @entity7 is involved in the pathogenesis of @entity3 in @entity0 with systemic immune-mediated diseases.

title: Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in XXXX with @entity3 .

answer: @entity0


abstract: INTRODUCTION: The mainstay treatment for @entity4 ( @entity4 ) is complete excision. Surgical approach should allow maximal exposure of the @entity1 with minimum morbidity. One such possible approach is Lefort I maxillary osteotomy. OBJECTIVE: To review our experience on feasibility of @entity2 to achieve the best result and to look at the outcome in our series of @entity0 at a tertiary centre in India. METHOD: This prospective study involves 22 @entity0 with @entity4 who have been treated by Lefort I approach between August 2006 and December 2007 at the Department of Neurosurgery, National Institute of Mental Health And Neurosciences, Bangalore, India. RESULTS: All @entity0 underwent primary surgical resection through Lefort I approach. No major intra-operative and post-operative complications were noted except in one @entity0 where @entity3 in one eye due to prior pre-operative orbital involvement. The mean follow-up period was 2.8 years. To date, there has been no cases of @entity1 or recurrence that can be attributed to the procedure except in one case. CONCLUSION: Our experience suggests that the @entity2 is a useful technique for the removal of extensive @entity4 which has distinct advantages over traditional approaches, providing a more direct vision, improved exposure, and cosmesis.

title: Le Fort I access for juvenile XXXX ( @entity4 ): a prospective series of 22 cases.

answer: @entity4


abstract: INTRODUCTION: The mainstay treatment for @entity4 ( @entity4 ) is complete excision. Surgical approach should allow maximal exposure of the @entity1 with minimum morbidity. One such possible approach is Lefort I maxillary osteotomy. OBJECTIVE: To review our experience on feasibility of @entity2 to achieve the best result and to look at the outcome in our series of @entity0 at a tertiary centre in India. METHOD: This prospective study involves 22 @entity0 with @entity4 who have been treated by Lefort I approach between August 2006 and December 2007 at the Department of Neurosurgery, National Institute of Mental Health And Neurosciences, Bangalore, India. RESULTS: All @entity0 underwent primary surgical resection through Lefort I approach. No major intra-operative and post-operative complications were noted except in one @entity0 where @entity3 in one eye due to prior pre-operative orbital involvement. The mean follow-up period was 2.8 years. To date, there has been no cases of @entity1 or recurrence that can be attributed to the procedure except in one case. CONCLUSION: Our experience suggests that the @entity2 is a useful technique for the removal of extensive @entity4 which has distinct advantages over traditional approaches, providing a more direct vision, improved exposure, and cosmesis.

title: Le Fort I access for juvenile @entity4 ( XXXX ): a prospective series of 22 cases.

answer: @entity4


abstract: The need for safe and effective topical treatments is underlined by several clinical trials over the years treating @entity1 with many and heterologous drugs, sometimes on a simple empirical basis. In a recent study Robinson and Kligman claimed to have obtained satisfactory results treating several cases of @entity4 with an alternate regimen of @entity3 and @entity2 . We wish to report an open-label pilot study using a simple and readily accessible combination of commercially formulated and available agents as 0,05% @entity3 cream and 5% @entity2 cream over two groups of @entity0 . Treatment consisted of bid application of sparing amounts of an equal parts combination of @entity3 and @entity2 . The first group consisted of 7 @entity0 affected by @entity1 associated with an altered epidermal keratinization ( @entity4 , @entity6 , @entity7 , phrynoderma and @entity5 ). The @entity0 were followed up for a period of 15 to 60 days and, as it might be expected, the results were quite good. The second group, on the contrary, consisted of 6 @entity0 affected mainly by @entity1 involving the corium (LED, milium, colloid pseudomilium). The @entity0 were followed up for the same period of time as the first group was, but the results were much less rewarding. Only a partial resolution of the process, which was followed soon after by a relapse, was noted. Finally we believe that this modified regimen of equal parts of @entity3 and @entity2 has to be recommended in the topical treatment of the above mentioned @entity1 associated with an altered keratinization.

title: [ @entity3 and XXXX mixture in the topical treatment of several @entity1 (author's transl)].

answer: @entity2


abstract: The need for safe and effective topical treatments is underlined by several clinical trials over the years treating @entity1 with many and heterologous drugs, sometimes on a simple empirical basis. In a recent study Robinson and Kligman claimed to have obtained satisfactory results treating several cases of @entity4 with an alternate regimen of @entity3 and @entity2 . We wish to report an open-label pilot study using a simple and readily accessible combination of commercially formulated and available agents as 0,05% @entity3 cream and 5% @entity2 cream over two groups of @entity0 . Treatment consisted of bid application of sparing amounts of an equal parts combination of @entity3 and @entity2 . The first group consisted of 7 @entity0 affected by @entity1 associated with an altered epidermal keratinization ( @entity4 , @entity6 , @entity7 , phrynoderma and @entity5 ). The @entity0 were followed up for a period of 15 to 60 days and, as it might be expected, the results were quite good. The second group, on the contrary, consisted of 6 @entity0 affected mainly by @entity1 involving the corium (LED, milium, colloid pseudomilium). The @entity0 were followed up for the same period of time as the first group was, but the results were much less rewarding. Only a partial resolution of the process, which was followed soon after by a relapse, was noted. Finally we believe that this modified regimen of equal parts of @entity3 and @entity2 has to be recommended in the topical treatment of the above mentioned @entity1 associated with an altered keratinization.

title: [ @entity3 and @entity2 mixture in the topical treatment of several XXXX (author's transl)].

answer: @entity1


abstract: The need for safe and effective topical treatments is underlined by several clinical trials over the years treating @entity1 with many and heterologous drugs, sometimes on a simple empirical basis. In a recent study Robinson and Kligman claimed to have obtained satisfactory results treating several cases of @entity4 with an alternate regimen of @entity3 and @entity2 . We wish to report an open-label pilot study using a simple and readily accessible combination of commercially formulated and available agents as 0,05% @entity3 cream and 5% @entity2 cream over two groups of @entity0 . Treatment consisted of bid application of sparing amounts of an equal parts combination of @entity3 and @entity2 . The first group consisted of 7 @entity0 affected by @entity1 associated with an altered epidermal keratinization ( @entity4 , @entity6 , @entity7 , phrynoderma and @entity5 ). The @entity0 were followed up for a period of 15 to 60 days and, as it might be expected, the results were quite good. The second group, on the contrary, consisted of 6 @entity0 affected mainly by @entity1 involving the corium (LED, milium, colloid pseudomilium). The @entity0 were followed up for the same period of time as the first group was, but the results were much less rewarding. Only a partial resolution of the process, which was followed soon after by a relapse, was noted. Finally we believe that this modified regimen of equal parts of @entity3 and @entity2 has to be recommended in the topical treatment of the above mentioned @entity1 associated with an altered keratinization.

title: [ XXXX and @entity2 mixture in the topical treatment of several @entity1 (author's transl)].

answer: @entity3


abstract: 240 young doctors undergoing a residency programme in a medical school in India were individually interviewed for pattern and extent of @entity1 . @entity1 was operationally defined as "Indulgence in a drug with a frequency of at least once a month without medical prescription". Of the doctors 30.4% were categorised as drug abusers currently, 14.2% had used one or the other drug in the past, and 17.9% had never used any drug. A significantly higher level of abuse was observed among male doctors (37.1%) than female doctors (2.2%). @entity0 was most commonly abused (17.9%). Minor tranquilizers were abused by 17.5%. None of the doctors was abusing any substances on a daily basis. No hard drugs were abused. Common reasons for @entity0 intake were for the sake of company and curiosity. Minor tranquilizers and @entity2 were taken for their pharmacological effects.

title: XXXX among resident doctors.

answer: @entity1


abstract: From a representative group from the adult population (34.958) of a town of 77.384 inhabitants, 99 @entity0 were selected who: a) claimed to be periodically dyspneic independently with respect to @entity7 . b) had normal chest x-rays and normal PE flow values. Approximately one year later, a history of @entity1 was taken from 79 of them, and intradermal skin tests were performed with some @entity9 . At this time, 15 @entity0 failed to report their previous complaints of @entity6 . Only 5 @entity0 reported that various vegetables and pickles were responsible for their @entity2 or @entity4 . Only 2 @entity0 admitted various gastrointestinal symptoms, but non mentioned milk, eggs or cereals as possible causative agents of their bronchial, nasal, skin or circulatory symptoms. Distinctly positive immediate type skin reactions to the mixed milk and egg allergen were recorded in 19 @entity0 (24%), and to cereals in 11 @entity0 (14%). They all reacted strongly also to the house dust allergen, but they did not differ from all the remaining subjects in the intensity of their skin response to the control solution of @entity3 . @entity0 with positive skin reactions to cereals or dairy products complained of chronic or recurrent @entity8 much more often than the others (73% and 63% compared with 35%). Forty-five (47%) of them had a positive personal history of @entity2 or @entity4 . These "food reactors" did not differ from "non reactors" in the frequency of the elevated serum @entity10 level which was raised in 66% of the whole group (of 79). The results suggest that @entity5 to cereals and dairy products may often be underestimated in adult asthmatics especially when positive reactions to inhalants are also present. The problems of reliability of the skin tests and history taking in food @entity5 are briefly discussed.

title: XXXX to cereals and dairy products in adult, uncomplicated asthma: an epidemiological survey.

answer: @entity5


abstract: BACKGROUND: @entity4 complicated by intra-abdominal @entity6 ( @entity6 ) is uncommon. There are no reports on @entity0 with this type of @entity3 , in which the pre-operative treatment (including diagnosis), surgical approach, post-operative pathologic reports, and prognosis are discussed. METHOD: The clinicopathological features of a 49-year-old @entity0 were retrospectively analyzed. RESULTS: @entity4 located in the inferior segment of the bile duct was considered pre-operatively on the basis of clinical findings. At the time of pancreaticoduodenectomy, the mesojejunum was stiff without nodules or a mass at a distance of approximately 80 cm from the ligament of Treitz. Complete excision of the entire lesion of the intestinal mesenteric contracture and its subsidiary was performed. Post-operative pathologic findings confirmed an @entity5 located at the extremity of the common bile duct and infiltrating the full thickness of the common bile duct as well as the deep muscular layer of the duodenum. The contracted jejunal mesentery was shown to have @entity6 . The @entity0 was alive with no evidence of recurrence after a follow-up of 6 months. CONCLUSIONS: The @entity0 had a rare @entity1 with intra-abdominal @entity6 , which manifests the characteristics of an aggressive growth pattern and a high rate of local recurrence; conservative therapy is recommended. Complete excision of the @entity2 during pancreaticoduodenectomy may maximally decrease the risk of local recurrence.

title: XXXX accompanied by @entity6 .

answer: @entity4


abstract: BACKGROUND: @entity4 complicated by intra-abdominal @entity6 ( @entity6 ) is uncommon. There are no reports on @entity0 with this type of @entity3 , in which the pre-operative treatment (including diagnosis), surgical approach, post-operative pathologic reports, and prognosis are discussed. METHOD: The clinicopathological features of a 49-year-old @entity0 were retrospectively analyzed. RESULTS: @entity4 located in the inferior segment of the bile duct was considered pre-operatively on the basis of clinical findings. At the time of pancreaticoduodenectomy, the mesojejunum was stiff without nodules or a mass at a distance of approximately 80 cm from the ligament of Treitz. Complete excision of the entire lesion of the intestinal mesenteric contracture and its subsidiary was performed. Post-operative pathologic findings confirmed an @entity5 located at the extremity of the common bile duct and infiltrating the full thickness of the common bile duct as well as the deep muscular layer of the duodenum. The contracted jejunal mesentery was shown to have @entity6 . The @entity0 was alive with no evidence of recurrence after a follow-up of 6 months. CONCLUSIONS: The @entity0 had a rare @entity1 with intra-abdominal @entity6 , which manifests the characteristics of an aggressive growth pattern and a high rate of local recurrence; conservative therapy is recommended. Complete excision of the @entity2 during pancreaticoduodenectomy may maximally decrease the risk of local recurrence.

title: @entity4 accompanied by XXXX .

answer: @entity6


abstract: A 30-year experience in the management of 283 consecutive @entity0 with acute @entity6 was reviewed. Of these injuries 224 were penetrating; 59 were from blunt @entity1 . Diagnosis was made by laparotomy in all @entity0 , although elevated serum amylase suggested this injury in 23 (56%) of 41 @entity0 with nonpenetrating injuries. Operative measures were initially involved with correction of associated injury when present (961 organ injuries in 278 @entity0 : 3.5 injuries per @entity0 ). During the earlier years, Penrose drains were placed to the site of injury. Significant @entity4 ( @entity2 in 13, @entity6 or @entity5 in six, pseudocyst in three) were noted in 19 (46%) of the 41 @entity0 so managed. Routine sump drainage dramatically reduced the incidence of @entity4 to 2% in the 198 @entity0 having external drainage alone. Distal resection was performed in 29 @entity0 , without later @entity8 . Most disappointing were the results from Roux-en-Y internal drainage: @entity2 developed in five and lethal bacterial @entity6 in three of the seven @entity0 so treated. Five @entity0 died from exsanguination during exploration for major vascular @entity1 , and all three @entity0 undergoing pancreaticoduodenectomy succumbed within 20 hours after operation. The overall mortality was 13.8%, with only seven deaths out of the last 100 @entity0 treated. Profound @entity3 and its complications (19), @entity6 (eight), and post-traumatic @entity7 (three) accounted for 30 of the 39 fatalities.

title: Experiences in the management of XXXX .

answer: @entity6


abstract: Expeditious surgical management in serious @entity2 improves survival rates. However, guidelines for emergency thoracotomy that depend on the initial amount of @entity1 or continuing @entity1 are imprecise and frequently require a period of observation. In an attempt to improve prethoracotomy diagnosis emergency thoracoscopy was used in the operating room in 36 @entity0 who presented with hemothoraces. A diagnostic thoracoscope was inserted through the previously placed incisions for chest tubes. The procedure was well tolerated under local anesthesia and in most @entity0 took less than 15 minutes to complete. No complications resulted from thoracoscopy. When the information obtained did not indicate further operations, the thoracoscope was withdrawn and chest tubes were reinserted through the same incisions. The method provided anatomic definition of the injuries in 35 of 36 @entity0 and allowed the determination of whether @entity1 was continuing. Management was altered as a result of thoracoscopy in 16 @entity0 (44.4%). An unnecessary thoracotomy was avoided in 16 @entity0 who had greater than 1,500 ml of blood in the thoracic cavity on admission and allowed a more rapid thoracotomy in one @entity0 . Four @entity0 had wounds located close to the diaphragm and laparotomy was avoided when the diaphragm was found free of injury. Bleeding from lacerated intercostal vessels was stopped with diathermy during thoracoscopy in two of three @entity0 . In addition, 15 @entity0 had 200 ml or more of clotted blood removed. The usefulness of @entity4 remains to be proved but it is hoped that the incidence of @entity3 will be reduced. Emergency thoracoscopy has proved a valuable diagnostic and therapeutic measure in @entity0 sustaining penetrating @entity2 .

title: Emergency thoracoscopy: a logical approach to XXXX management.

answer: @entity2


abstract: @entity0 suffering from severe @entity2 have to rely on non-verbal means of communication to convey a message. However, to date it is not clear which @entity0 are able to do so. Clinical experience indicates that some @entity0 use non-verbal communication strategies like gesturing very efficiently whereas others fail to transmit semantic content by non-verbal means. Concerns have been expressed that limb @entity1 would affect the production of communicative gestures. Research investigating if and how @entity1 influences the production of communicative gestures, led to contradictory outcomes. The purpose of this study was to investigate the impact of limb @entity1 on spontaneous gesturing. Further, linguistic and non-verbal semantic processing abilities were explored as potential factors that might influence non-verbal expression in aphasic @entity0 . Twenty-four aphasic @entity0 with highly limited verbal output were asked to retell short video-clips. The narrations were videotaped. Gestural communication was analyzed in two ways. In the first part of the study, we used a form-based approach. Physiological and kinetic aspects of hand movements were transcribed with a notation system for sign languages. We determined the formal diversity of the hand gestures as an indicator of potential richness of the transmitted information. In the second part of the study, comprehensibility of the @entity0 ' gestural communication was evaluated by naive raters. The raters were familiarized with the model video-clips and shown the recordings of the @entity0 ' retelling without sound. They were asked to indicate, for each narration, which story was being told and which aspects of the stories they recognized. The results indicate that non-verbal faculties are the most important prerequisites for the production of hand gestures. Whereas results on standardized @entity2 testing did not correlate with any gestural indices, non-verbal semantic processing abilities predicted the formal diversity of hand gestures while @entity1 predicted the comprehensibility of gesturing.

title: Non-verbal communication in severe @entity2 : influence of XXXX , @entity1 , or semantic processing?

answer: @entity2


abstract: @entity0 suffering from severe @entity2 have to rely on non-verbal means of communication to convey a message. However, to date it is not clear which @entity0 are able to do so. Clinical experience indicates that some @entity0 use non-verbal communication strategies like gesturing very efficiently whereas others fail to transmit semantic content by non-verbal means. Concerns have been expressed that limb @entity1 would affect the production of communicative gestures. Research investigating if and how @entity1 influences the production of communicative gestures, led to contradictory outcomes. The purpose of this study was to investigate the impact of limb @entity1 on spontaneous gesturing. Further, linguistic and non-verbal semantic processing abilities were explored as potential factors that might influence non-verbal expression in aphasic @entity0 . Twenty-four aphasic @entity0 with highly limited verbal output were asked to retell short video-clips. The narrations were videotaped. Gestural communication was analyzed in two ways. In the first part of the study, we used a form-based approach. Physiological and kinetic aspects of hand movements were transcribed with a notation system for sign languages. We determined the formal diversity of the hand gestures as an indicator of potential richness of the transmitted information. In the second part of the study, comprehensibility of the @entity0 ' gestural communication was evaluated by naive raters. The raters were familiarized with the model video-clips and shown the recordings of the @entity0 ' retelling without sound. They were asked to indicate, for each narration, which story was being told and which aspects of the stories they recognized. The results indicate that non-verbal faculties are the most important prerequisites for the production of hand gestures. Whereas results on standardized @entity2 testing did not correlate with any gestural indices, non-verbal semantic processing abilities predicted the formal diversity of hand gestures while @entity1 predicted the comprehensibility of gesturing.

title: Non-verbal communication in severe XXXX : influence of @entity2 , @entity1 , or semantic processing?

answer: @entity2


abstract: @entity0 suffering from severe @entity2 have to rely on non-verbal means of communication to convey a message. However, to date it is not clear which @entity0 are able to do so. Clinical experience indicates that some @entity0 use non-verbal communication strategies like gesturing very efficiently whereas others fail to transmit semantic content by non-verbal means. Concerns have been expressed that limb @entity1 would affect the production of communicative gestures. Research investigating if and how @entity1 influences the production of communicative gestures, led to contradictory outcomes. The purpose of this study was to investigate the impact of limb @entity1 on spontaneous gesturing. Further, linguistic and non-verbal semantic processing abilities were explored as potential factors that might influence non-verbal expression in aphasic @entity0 . Twenty-four aphasic @entity0 with highly limited verbal output were asked to retell short video-clips. The narrations were videotaped. Gestural communication was analyzed in two ways. In the first part of the study, we used a form-based approach. Physiological and kinetic aspects of hand movements were transcribed with a notation system for sign languages. We determined the formal diversity of the hand gestures as an indicator of potential richness of the transmitted information. In the second part of the study, comprehensibility of the @entity0 ' gestural communication was evaluated by naive raters. The raters were familiarized with the model video-clips and shown the recordings of the @entity0 ' retelling without sound. They were asked to indicate, for each narration, which story was being told and which aspects of the stories they recognized. The results indicate that non-verbal faculties are the most important prerequisites for the production of hand gestures. Whereas results on standardized @entity2 testing did not correlate with any gestural indices, non-verbal semantic processing abilities predicted the formal diversity of hand gestures while @entity1 predicted the comprehensibility of gesturing.

title: Non-verbal communication in severe @entity2 : influence of @entity2 , XXXX , or semantic processing?

answer: @entity1


abstract: BACKGROUND: Biopsy with demonstration of the infectious organism is the gold standard for diagnosing @entity4 . The purpose of this study is to evaluate the positive culture rate of image-guided percutaneous biopsy in cases of radiologically suspected and unsuspected @entity5 and to assess the role of pathology in diagnosis. METHODS: With IRB approval and in compliance with HIPAA regulations, the charts of @entity0 undergoing 323 consecutive image-guided percutaneous spinal biopsies performed by one musculoskeletal radiology department between January 2001 and March 2007 were reviewed. Image guidance was via fluoroscopy or computed tomography. Radiological and clinical suspicion, cultures, and pathology were assessed and compared to previously published reports. RESULTS: In 92 cases radiographically and clinically consistent with @entity2 (high probability of @entity2 ), 28 specimens yielded positive cultures (30.4%). Positive cultures resulted from 5 of 31 cases (16.1%) radiographically indeterminate for @entity2 (intermediate probability of @entity1 ). When radiographically not suggestive of @entity2 (low probability of @entity2 , i.e. suspicious for @entity1 ), 10 of 200 cultures were positive (5.0%). From 113 cases sent to pathology with an intermediate or high suspicion for @entity2 , 63 were histopathologically diagnosed as such (55.8%). Cultures were positive in 19 of those 63 cases (30.2%). Culture and/or pathology was positive in 73 (64.6%) of the 113 cases. There were no significant differences in rates of positive culture or pathology by vertebral region (p=0.51, p=0.81). The most frequently identified organisms were @entity3 (13) and coagulase negative staphylococci (13). CONCLUSIONS: Our results suggest that the positive culture rate of percutaneous spinal biopsy specimens is 30.4% with radiographically high probability for @entity2 , which is lower than previously published. Infection may also be present in cases with imaging characteristics atypical for @entity2 (5.0%). Careful consideration must be given to the interpretation of negative culture results. LEVEL OF EVIDENCE: This retrospective review of 323 consecutive percutaneous spine biopsies is level III evidence.

title: Percutaneous needle biopsy in diagnosis and identification of causative organisms in cases of suspected XXXX .

answer: @entity5


abstract: Four @entity0 with @entity3 ( @entity3 ) and @entity11 ( @entity11 ) underwent successful intracardiac repair. All @entity0 had undergone preliminary palliative shunts. Associated @entity1 included muscular @entity9 ( @entity9 ) and left superior vena cava (one @entity0 ), bilateral main @entity7 (one @entity0 ), and right aortic arch (two @entity0 ). The diagnosis was suspected clinically by electrocardiographic evidence of @entity10 and @entity8 , by echocardiographic findings suggestive of @entity11 with aortic dextroposition, and by the association with trisomy 21. The diagnosis was confirmed by cardiac catheterization and cineangiography. Total correction consisted of closure of the @entity9 and @entity2 ( @entity2 ), reconstruction of the @entity4 , and relief of the right ventricular outflow tract obstruction (RVOTO). There were no early or late postoperative deaths. @entity6 did not occur. One @entity0 underwent successful reoperation for residual @entity9 and right ventricular outflow @entity5 . Late hemodynamic evaluation revealed good results in all @entity0 . We recommend a staged treatment plan consisting of preliminary systemic--pulmonary artery shunting for symptomatic @entity0 under 4 to 5 years of age and total correction for older @entity0 . With proper preoperative diagnosis and accurate intracardiac repair, good results may be obtained after total correction of @entity3 and @entity11 .

title: Results of total correction of XXXX with @entity11 .

answer: @entity3


abstract: Four @entity0 with @entity3 ( @entity3 ) and @entity11 ( @entity11 ) underwent successful intracardiac repair. All @entity0 had undergone preliminary palliative shunts. Associated @entity1 included muscular @entity9 ( @entity9 ) and left superior vena cava (one @entity0 ), bilateral main @entity7 (one @entity0 ), and right aortic arch (two @entity0 ). The diagnosis was suspected clinically by electrocardiographic evidence of @entity10 and @entity8 , by echocardiographic findings suggestive of @entity11 with aortic dextroposition, and by the association with trisomy 21. The diagnosis was confirmed by cardiac catheterization and cineangiography. Total correction consisted of closure of the @entity9 and @entity2 ( @entity2 ), reconstruction of the @entity4 , and relief of the right ventricular outflow tract obstruction (RVOTO). There were no early or late postoperative deaths. @entity6 did not occur. One @entity0 underwent successful reoperation for residual @entity9 and right ventricular outflow @entity5 . Late hemodynamic evaluation revealed good results in all @entity0 . We recommend a staged treatment plan consisting of preliminary systemic--pulmonary artery shunting for symptomatic @entity0 under 4 to 5 years of age and total correction for older @entity0 . With proper preoperative diagnosis and accurate intracardiac repair, good results may be obtained after total correction of @entity3 and @entity11 .

title: Results of total correction of @entity3 with XXXX .

answer: @entity11


abstract: BACKGROUND: Individuals with @entity2 sway more than control individuals while standing. This review specifically evaluated whether @entity1 can be the only fundamental reason accounting for significant increased sway within this population. METHODS: Twenty-six experimental articles were selected using MEDLINE and reference lists of relevant articles. The articles chosen investigated kinematic data of postural behaviour in controls and individuals with @entity2 during stance. Results of literature were compared with four expectations related to the @entity1 fundamental hypothesis. FINDINGS: Consistent with the @entity1 hypothesis, the literature showed that individuals with @entity2 sway more than controls in quiet stance and even more so if their visual or vestibular systems were perturbed. Inconsistent with the hypothesis, individuals with @entity2 are more destabilised than controls in conditions altering sensation of the feet and legs (standing on a sway-referenced surface). INTERPRETATION: The review showed that the @entity1 hypothesis may not be the only fundamental cause accounting for significant increased postural sway in individuals with @entity2 . @entity0 and changes in postural coordination may explain the divergence between expectations and results. In order to develop interventions aimed at improving postural control in individuals with @entity2 , scientific exploration of these new expectations should be detailed. Also at the practical level, the review discussed which additional sensory information - at the level of the hands and feet - may be more beneficial in individuals with @entity2 to reduce their postural sway.

title: XXXX may not be the only fundamental reason explaining increased sway in diabetic individuals.

answer: @entity1


abstract: OBJECTIVE: @entity1 repair (EVAR) has reduced early adverse outcomes from @entity2 ( @entity2 ) repair. Preferential use of EVAR may have altered the profile of @entity0 who undergo open repair. The validity of scoring systems such as the Glasgow @entity1 Score (GAS), devised when open surgery was the only treatment, required reappraisal. METHODS: @entity0 were identified from a database of @entity0 undergoing elective infrarenal aneurysm repair at seven United Kingdom centers, and the GAS was calculated for each @entity0 . Discrimination and calibration were calculated to determine the performance of the model in this setting using the C statistic, tertile analysis, and the   (2) test. Univariate analysis was performed to determine if a new iteration of the GAS could be produced. RESULTS: We identified 330 @entity0 who met the inclusion criteria. There were 18 deaths  <=30 days of surgery (5.4%). The average (standard deviation) GAS was 78.6 (8.8) for the survivors and 81.9 (10.4) for nonsurvivors (P = .122). The C statistic was 0.625 (95% confidence interval, 0.481-0.769; P = .75) suggesting a discriminatory ability not much better than chance alone. Despite this, calibration of the model was good. There was no significant difference in the comorbidities of either group, so no recalibration of the GAS could be performed. CONCLUSION: The GAS did not discriminate between survivors and nonsurvivors after open @entity2 repair in this cohort. In the era of EVAR, it is possible that the GAS does not predict the outcome of open @entity2 repair. An alternative explanation is that @entity0 with risk factors for poor outcomes from EVAR, such as adverse @entity2 morphology, are being selected out for open repair.

title: The Glasgow @entity1 Score does not predict mortality after open @entity2 in the era of XXXX repair.

answer: @entity1


abstract: OBJECTIVE: @entity1 repair (EVAR) has reduced early adverse outcomes from @entity2 ( @entity2 ) repair. Preferential use of EVAR may have altered the profile of @entity0 who undergo open repair. The validity of scoring systems such as the Glasgow @entity1 Score (GAS), devised when open surgery was the only treatment, required reappraisal. METHODS: @entity0 were identified from a database of @entity0 undergoing elective infrarenal aneurysm repair at seven United Kingdom centers, and the GAS was calculated for each @entity0 . Discrimination and calibration were calculated to determine the performance of the model in this setting using the C statistic, tertile analysis, and the   (2) test. Univariate analysis was performed to determine if a new iteration of the GAS could be produced. RESULTS: We identified 330 @entity0 who met the inclusion criteria. There were 18 deaths  <=30 days of surgery (5.4%). The average (standard deviation) GAS was 78.6 (8.8) for the survivors and 81.9 (10.4) for nonsurvivors (P = .122). The C statistic was 0.625 (95% confidence interval, 0.481-0.769; P = .75) suggesting a discriminatory ability not much better than chance alone. Despite this, calibration of the model was good. There was no significant difference in the comorbidities of either group, so no recalibration of the GAS could be performed. CONCLUSION: The GAS did not discriminate between survivors and nonsurvivors after open @entity2 repair in this cohort. In the era of EVAR, it is possible that the GAS does not predict the outcome of open @entity2 repair. An alternative explanation is that @entity0 with risk factors for poor outcomes from EVAR, such as adverse @entity2 morphology, are being selected out for open repair.

title: The Glasgow XXXX Score does not predict mortality after open @entity2 in the era of @entity1 repair.

answer: @entity1


abstract: OBJECTIVE: @entity1 repair (EVAR) has reduced early adverse outcomes from @entity2 ( @entity2 ) repair. Preferential use of EVAR may have altered the profile of @entity0 who undergo open repair. The validity of scoring systems such as the Glasgow @entity1 Score (GAS), devised when open surgery was the only treatment, required reappraisal. METHODS: @entity0 were identified from a database of @entity0 undergoing elective infrarenal aneurysm repair at seven United Kingdom centers, and the GAS was calculated for each @entity0 . Discrimination and calibration were calculated to determine the performance of the model in this setting using the C statistic, tertile analysis, and the   (2) test. Univariate analysis was performed to determine if a new iteration of the GAS could be produced. RESULTS: We identified 330 @entity0 who met the inclusion criteria. There were 18 deaths  <=30 days of surgery (5.4%). The average (standard deviation) GAS was 78.6 (8.8) for the survivors and 81.9 (10.4) for nonsurvivors (P = .122). The C statistic was 0.625 (95% confidence interval, 0.481-0.769; P = .75) suggesting a discriminatory ability not much better than chance alone. Despite this, calibration of the model was good. There was no significant difference in the comorbidities of either group, so no recalibration of the GAS could be performed. CONCLUSION: The GAS did not discriminate between survivors and nonsurvivors after open @entity2 repair in this cohort. In the era of EVAR, it is possible that the GAS does not predict the outcome of open @entity2 repair. An alternative explanation is that @entity0 with risk factors for poor outcomes from EVAR, such as adverse @entity2 morphology, are being selected out for open repair.

title: The Glasgow @entity1 Score does not predict mortality after open XXXX in the era of @entity1 repair.

answer: @entity2


abstract: OBJECTIVE: The objective of this study is to examine contemporary management of primary @entity3 in a single center. We have previously reported the management of @entity3 in 15 @entity0 between 1991 and 2001, and we hypothesized that management would change in the light of the evolution of endovascular aortic repair. METHODS: A review of a prospectively collected database (2002-2009) of all @entity0 presenting with @entity5 . RESULTS: A total of 19 @entity2 were identified in 17 @entity0 (12 @entity0 , 5 @entity0 ) with a median age of 66.2 years (range, 49-82 years). All were symptomatic, and nine had contained @entity1 . There were five infrarenal, two juxtarenal, three Crawford type III, four type @entity4 , and five descending @entity2 in the series. All @entity2 were excluded by @entity2 repair. Two @entity0 underwent visceral hybrid endografting for @entity4 ; the third was treated with open repair. Four @entity0 underwent open type IV repair. Two of the @entity2 were treated with bifurcated @entity2 repair, and the other three and both juxtarenals with open repair with in situ reconstruction. There were three early (17.6%) and three late deaths (17.6%). The median follow-up was 30.5 months (range, 1-102 months). CONCLUSIONS: The results of the latest series show that open surgery is still required in many cases. The introduction of endovascular techniques in the exclusion of @entity5 can be accomplished with acceptable results, and endovascular treatment has increased the therapeutic options for a difficult condition.

title: The changing management of primary XXXX .

answer: @entity3


abstract: CONTEXT: Hospice care has increasingly been shown to affect quality of palliative care at both the individual and institutional levels. However, an institutional effect has only been addressed in single comprehensive @entity1 centers/selected community hospitals. OBJECTIVES: To investigate the impact of an inpatient hospice unit on the parent hospital's quality of palliative care. METHODS: This was a retrospective cohort study using administrative data from the entire population of 204,850 Taiwanese pediatric and adult @entity1 @entity0 who died in 2001-2006. Outcome variables were adjusted by multivariate logistic regression for five groups of confounding variables: 1) @entity0 demographics and disease characteristics, 2) primary hospital characteristics, 3) primary physician specialty, 4) health care resources at the hospital and regional levels, and 5) historical trend. RESULTS: Taiwanese @entity1 @entity0 who received primary care in a hospital with an inpatient hospice unit (whether or not they received hospice care) were significantly less likely to be intubated (adjusted odds ratio [AOR]: 0.71; 95% confidence interval [CI]: 0.58, 0.86) and use mechanical ventilation support (AOR: 0.70; 95% CI: 0.56, 0.87) in their last month of life. They also were more likely to use hospice care before death (AOR: 3.51; 95% CI: 1.57, 7.86). Furthermore, if they used hospice care, they tended to be referred earlier than @entity1 @entity0 being cared for in a hospital without an inpatient hospice unit. CONCLUSION: Integrating both acute care and palliative care approaches to caring for terminally ill @entity1 @entity0 in the same hospital may influence the quality of palliative care throughout the hospital as evidenced by our findings that these @entity0 have lower likelihood of being intubated with mechanical ventilation support in the last month of life, greater propensity to receive hospice care in the last year of life, and a trend toward earlier referral to hospice care. The generalizability of these results may be limited to @entity0 who died of a noncancer cause and by the two groups not being exactly matched for @entity0 ' characteristics.

title: Impact of availability of an inpatient hospice unit on the parent hospital's quality of palliative care for Taiwanese XXXX decedents, 2001-2006.

answer: @entity1


abstract: PURPOSE: To determine the efficacy of a home-based computer orthoptic program to treat symptomatic @entity4 . METHODS: A retrospective review of consecutive @entity0 with symptomatic @entity4 treated with a home-based computer orthoptic program was performed. Symptomatic @entity4 was defined as: @entity3 ( @entity3 ) >6 cm, decreased positive fusional vergence, exophoria at near at least 4(/\) greater than at far, and documented complaints of @entity5 , @entity2 , or @entity1 with reading or near work. The Computer Orthoptics CVS program was used for this study. Before beginning the computer orthoptic program, @entity0 with an @entity3 >50 cm were given 4 base-in prisms and push-up exercises ( @entity3 exercises with an accommodative target) for 2 weeks. RESULTS: A total of 42 @entity0 were included. Mean treatment duration was 12.6 weeks; mean follow-up, 8.5 months. Of the 42 @entity0 , 35 were treated with the home-based computer orthoptic program and push-up exercises; the remaining 7 only used the computer orthoptic program. Because of a remote @entity3 , 5 @entity0 were given base-in Fresnel prism before starting treatment. Baseline mean @entity3 was 24.2 cm; posttreatment mean @entity3 improved to 5.6 cm: 39 @entity0 (92.8%) achieved an @entity3 of  <=6 cm (p < 0.001). Positive fusional vergence improved in 39 @entity0 (92.8%). Fourteen @entity0 reduced their near exophoria by >= 5(/\). A total of 27 @entity0 (64.2%) reported resolution of symptoms after treatment. CONCLUSIONS: In our study, home-based computer orthoptic exercises reduced symptoms and improved @entity3 and fusional amplitudes. The computer orthoptic program is an effective option for treating symptomatic @entity4 .

title: Treatment of symptomatic XXXX with a home-based computer orthoptic exercise program.

answer: @entity4


abstract: Quantitative analyses of the bound water content in the @entity0 aqueous solution and its osmotic behavior should be cryobiologically significant. This paper has presented two applications of the thermogram of the @entity0 /water system recorded by differential scanning calorimeter (DSC). Both applications are: (1) generating the quantitative relationship between the bound water content and the solution composition; (2) calculating the osmotic virial coefficients for @entity5 . Five @entity5 including @entity2 , @entity3 , @entity6 , @entity4 and @entity1 are investigated. In the present study, partial binary phase diagrams of these five @entity0 solutions are determined in the first place. The bound water contents in these solutions are quantitatively evaluated by three criteria afterwards. In the end, the osmotic virial coefficients for these @entity5 are calculated according to the osmotic virial equation. It is turned out that the bound water fraction out of the total water content increases with a rising molality. The ability of the solute to restrict water molecules can be weakened when the solution becomes more concentrated. The results also indicate that @entity4 should be the strongest "water-blocker" while @entity2 the weakest one. These findings can deepen our understanding of the cryoprotective properties of the @entity5 from the perspectives of their roles in binding free water and promoting the osmotic efflux of cell water.

title: Two applications of the thermogram of the XXXX /water binary system with compositions of cryobiological interests.

answer: @entity0


abstract: CONTEXT: @entity4 is common in ageing @entity0 ; its natural history and predisposing factors are unclear. OBJECTIVES: 1) To identify factors which predispose eugonadal @entity0 (T >= 10.5nmol/L) to develop biochemical @entity4 (T<10.5nmol/L, LH <=9.4U/L) and secondary hypogonadal @entity0 to recover to eugonadism. 2) To characterize clinical features associated with these transitions. DESIGN: Prospective observational general population cohort survey. SETTING: Clinical research centres. @entity0 : 3369 community-dwelling @entity0 aged 40-79 yr in eight European centres. INTERVENTION: Observational follow-up of 4.3 years. MAIN OUTCOME MEASURE: Subjects were categorised according to change/no change in biochemical gonadal status during follow-up into persistent eugonadal (n=1909), incident secondary hypogonadal (n=140), persistent secondary hypogonadal (n=123) and recovered from @entity4 to eugonadism (n=96). Baseline predictors and changes in clinical features associated with incident @entity4 and recovery from @entity4 were analysed by regression models. RESULTS: The incidence of @entity4 was 155.9/10,000/year, while 42.9% of @entity0 with @entity4 recovered to eugonadism. Incident @entity4 was predicted by obesity [BMI>= 30kg/m(2): odds ratio (OR)=2.86 (95% confidence interval 1.67;4.90); p<0.0001], @entity3 [OR=1.79 (1.15;2.80);p=0.011] and increased waist circumference [OR=1.73 (1.07;2.81); p=0.026 and 2.64 (1.66;4.21);p<0.0001, for waist circumference 94-102 and >= 102 cm, respectively]. Incident secondary hypogonadal @entity0 experienced new/worsening sexual symptoms [low libido, @entity1 and infrequent spontaneous erections]. Recovery from @entity4 was predicted by non-obesity [OR=2.28 (1.21;4.31); p=0.011], @entity2 [OR=2.24 (1.04;4.85); p=0.042], normal waist circumference [OR=1.93 (1.01;3.70); p=0.048], younger age [<60yr OR=2.32 (1.12;4.82); p=0.024] and higher education [OR=2.11 (1.05;4.26); p=0.037], but symptoms did not show significant concurrent improvement. CONCLUSION: Obesity-related metabolic and lifestyle factors predispose older @entity0 to the development of @entity4 , which is frequently reversible with @entity2 .

title: Development of and Recovery from Secondary Hypogonadism in Ageing XXXX : Prospective Results from the EMAS.

answer: @entity0


abstract: PURPOSE: To evaluate CT- @entity2 of residual masses in @entity0 with follicular @entity3 (FL) at end-treatment compared to baseline mass density and determine its potential prognostic relevance. MATERIALS AND METHODS: 52 consecutive @entity0 with FL presenting with residual masses after chemotherapy receiving whole-body-CECT at baseline, end-treatment, and post-treatment were identified retrospectively by a search of our electronic medical record database from 2002 through 2010. An @entity2 ( @entity2 ), defined as the quotient of CT-attenuation [HU] between @entity1 and muscle was measured. Size was recorded as the product of long- and short-axis diameter of masses. In 38/52 @entity0 a follow-up period of >=  2 years was available to correlate results with relapse-free survival. RESULTS: @entity2 and @entity1 size of masses significantly decreased in responders when baseline was compared to end-treatment (n = 70; p < 0.05, respectively). An increase in both, @entity2 and size was recorded in case of relapse (n = 14; p < 0.05, respectively). 12/53 masses initially responded to therapy but relapsed within the consecutive 2-year period. The mean time to relapse was 13.5 months (range 5-24 months). @entity2 measured at the time of end-control was significantly lower in masses remaining stable for >=  2 years (n = 41) compared to masses with relapse during 2-year follow-up (n = 12; p < 0.05). At a threshold of an @entity2 >1 at end-control the specificity and sensitivity for relapsing disease within 2 years reached 83% and 75%, respectively. CONCLUSION: CT-attenuation measurements of residual masses in @entity0 with FL at end-control may aid in the risk stratification of early ( <= 2 years) relapsing disease.

title: Size and attenuation CT (SACT) of residual masses in @entity0 with XXXX : more than a status quo?

answer: @entity3