abstract: UNASSIGNED: @entity0 is a relatively new condition, and the criteria for its diagnosis have been developed only over the last several years. The criteria for @entity3 remain controversial. We strive to further elucidate the clinical validity of the diagnostic criteria for @entity3 . To test items of the diagnostic criteria for @entity3 among adolescents, we conducted a clinical interview study of college students based on longitudinal data on their risky use of the Internet. Forty-one high-risk cases were selected from a 3-year 5-time point longitudinal survey of 716 college freshmen. We examined disputes relevant to symptoms and impairment in the DC-IA-A (Diagnostic Criteria for Internet Addiction among Taiwanese Adolescents). Of the 41 cases, 21 were diagnosed with @entity3 via a @entity1 interview. In the @entity0 group, 23.8% of cases had a diagnosis of @entity2 , whereas only 15.0% of the cases in the non- @entity3 group had a diagnosis of @entity2 . Two major criteria (A8 and A3) had low incidences in these high-risk college students and thus did not help provide a differential diagnosis between the groups. We suggest that A8, 'excessive effort spent on activities necessary to obtain access to the Internet', should be omitted, and that A3, 'tolerance: a marked increase in the duration of Internet use needed to achieve satisfaction', should be modified. A1 and A9 should be discussed regarding their role in the diagnosis of @entity0 . Additional well-designed studies examining the diagnostic criteria and the relationship between factors are needed.

title: Examining the Application of the DC-IA-A Diagnostic Criteria for Internet XXXX in At-Risk College Students.

answer: @entity0


abstract: BACKGROUND: A variable decision in managing @entity3 ( @entity3 ) is the initial site of care; in- @entity0 versus outpatient. These variations persist despite comprehensive practice guidelines. @entity0 with a @entity2 Severity Index (PSI) score lower than seventy have low risk for complications and outpatient antibiotic management is recommended in this group. These @entity0 are generally below the age of fifty years, non-nursing home residents, @entity6 negative and have no major @entity1 . METHODS: A retrospective analysis of 296 low-risk @entity3 @entity0 evaluated within a year one period at St. Agnes Hospital, Baltimore, Maryland was undertaken. All @entity0 were assigned a PSI score. 208 (70%) were evaluated and discharged from the emergency department (E.D.) to complete outpatient antibiotic therapy, while 88 (30%) were hospitalized. @entity0 were sub-stratified into classes I-V according to PSI. A comparison of demographic, clinical, social and financial parameters was made between the E.D. discharged and hospitalized groups. RESULTS: Statistically significant differences in favor of the hospitalized group were noted for female gender (CI: 1.46-5.89, p= 0.0018), African Americans (CI: 0.31-0.73, p= 0.004), insurance coverage (CI: 0.19-0.63, p= 0.0034), temperature (CI: 0.04-0.09, p= 0.0001) and pulse rate (CI: 0.03-0.14, p= 0.0001). No statistically significant differences were observed between the two groups for altered mental status, @entity4 , @entity7 , laboratory/radiological parameters and social indicators (p>0.05). The average length of stay for in- @entity0 was 3.5 days at about eight time's higher cost than outpatient management. There was no difference in mortality or treatment failures between the two groups. The documentation rate and justifications for hospitalizing low risk @entity3 @entity0 by admitting physicians was less than optimal. CONCLUSIONS: High fever, @entity5 , female gender, African- American race and medical insurance coverage are determinants for hospitalization among low risk @entity3 @entity0 in our study. The average length of stay for in- @entity0 was 3.5 days (3 to 5 days). The cost of in- @entity0 care was about eight times higher than outpatient management. This study supports the recommendation of using the PSI for E.D evaluation of @entity0 in appropriate social settings.

title: Determinants for hospitalization in " low-risk" XXXX .

answer: @entity3


abstract: INTRODUCTION: Medical treatment for fulminat @entity6 seeks spontaneous recovery of the liver function, but the results are very discouraging (50-80% mortality). Liver transplantation is an option in @entity0 with a poor evolution despite medical treatment, with survival rates of > 50%. The ideal moment for performing the transplant is controversial, as it should not be done too soon, when the @entity3 is still reversible, or tool late, when the @entity0 is in an irreversible clinical situation. @entity0 AND METHOD: A retrospective review was made of the clinical histories of 34 @entity0 admitted to our hospital with a diagnosis of @entity4 , of whom 26 underwent transplantation. The most frequent cause was viral, with 10 cases (38%); no aetiology at all could be established in 11 cases (42%). Thirteen @entity0 had preoperative complications, the most frequent being @entity2 . As for degree of ABO/DR compatibility, 13 cases were identical (40%), 17 compatible (51%) and the other 3 incompatible (9%). RESULTS: Thirty-three transplants were performed in 26 @entity0 : 4 were retransplants due to chronic rejection, 2 for primary graft failure and 1 for hyperacute rejection. The overall mortality rate was 46% (12 @entity0 ), the most frequent cause of death being infection (50%). The overall actuarial survival rate was 68% at 1 year, 63% at 3 years and 59% at 5 years. The factors of poor prognosis were @entity2 , a grade D electroencephalogram, and @entity1 grades III and IV, the latter being the only prognostic factor identified in the multivariate analysis. The prognostic factors for mortality were a grade D electroencephalogram, @entity1 grades III and IV and @entity5 , the latter being the only prognostic factor identified in the multivariate analysis. CONCLUSIONS: The achievement of good results with the use of transplantation in the management of @entity4 depends on an optimum selection of transplant candidates, which means identifying them early, i.e. early indication for transplant, reduction in mean waiting time and exclusion of factors of poor prognosis.

title: [Fulminant XXXX and liver transplantation. Experience of the Hospital Virgen de la Arrixaca].

answer: @entity6


abstract: UNASSIGNED: @entity8 , expressed on greater than 90% of @entity6 , is a target for antibody therapy. Rituximab is a chimeric monoclonal antibody against the protein @entity8 , allowing it to destroy B cells and to treat @entity3 , @entity5 , transplant rejection, and @entity4 . In this work, the binding of Rituximab with @entity9 ( @entity9 ) of peptide mimotopes of @entity8 antigen was systematically characterized. Four peptide mimotopes of @entity8 were selected from literature and redesigned to allow their @entity9 immobilizations on gold electrodes through a peptide linker with @entity1 . The bindings of these peptides with Rituximab and control antibodies (Trastuzumab, and Bevacizumab) were characterized by Quartz Crystal Microbalance (QCM). Among the four peptide mimotopes initially selected, the peptide designated as CN-14 (CGSGSGSWPRWLEN) was the most selective and sensitive for Rituximab binding. The CN-14 @entity9 was further characterized by ellipsometry and atomic force microscopy. The thickness of the CN-14 @entity9 film was approximately 32    and the CN-14 @entity9 is suggested to be stabilized by a salt bridge of @entity2 -10 and GLU-13 between CN-14 peptides. The CN-14 salt bridge was evaluated by a series of modifications to the CN-14 peptide sequence and characterized by QCM. The CN-14 @entity7 variant produced a better affinity to Rituximab than that of CN-14 without a significant impact on selectivity. As the @entity0 residue pKa of CN-14 increased, the affinity of the @entity9 to Rituximab increased while the selectivity decreased. This was attributed to the weakening of the salt bridge between the CN-14 ARG-10 and GLU-13 at higher pKa values for GLU-13. Our study shows that peptide mimotopes have potential benefit in sensor applications as the peptide-peptide interactions in the @entity9 could be manipulated by the addition of functional groups to the peptide to influence binding of the target protein.

title: Characterization of Self-Assembled Monolayers of Peptide Mimotopes of XXXX Antigen and Their Binding with Rituximab.

answer: @entity8


abstract: We examined the pulmonary vascular response to an intravenous leukotriene D4 (LTD4) injection of (1 microgram X kg-1 X min-1 for 2 min) immediately followed by infusion of 0.133 microgram X kg-1 X min-1 for 15 min in awake @entity1 prepared with lung lymph fistulas. LTD4 resulted in rapid generation of @entity2 as measured by an increase in plasma @entity4 concentration. The @entity4 generation was associated with @entity0 while left atrial pressure did not change significantly. Pulmonary lymph flow (Qlym) increased (P less than 0.05) transiently from base line 6.87 +/- 1.88 (SE) ml/h to maximum value of 9.77 +/- 1.27 at 15 min following the LTD4 infusion. The maximum increase in Qlym was associated with an increase in the estimated pulmonary capillary pressure. The increase in Qlym was not associated with a change in the lymph-to-plasma protein concentration (L/P) ratio. Thromboxane synthetase inhibition with @entity6 (an @entity5 derivative) prevented @entity4 generation after LTD4 and also prevented the increases in pulmonary vascular pressures and Qlym. We conclude that LTD4 in awake @entity1 increases resistance of large pulmonary veins. The small transient increase in Qlym can be explained by the increase in pulmonary capillary pressure. @entity3 appears to mediate both the pulmonary hemodynamic and lymph responses to LTD4 in @entity1 .

title: Pulmonary vascular response to leukotriene D4 in unanesthetized XXXX : role of @entity3 .

answer: @entity1


abstract: We examined the pulmonary vascular response to an intravenous leukotriene D4 (LTD4) injection of (1 microgram X kg-1 X min-1 for 2 min) immediately followed by infusion of 0.133 microgram X kg-1 X min-1 for 15 min in awake @entity1 prepared with lung lymph fistulas. LTD4 resulted in rapid generation of @entity2 as measured by an increase in plasma @entity4 concentration. The @entity4 generation was associated with @entity0 while left atrial pressure did not change significantly. Pulmonary lymph flow (Qlym) increased (P less than 0.05) transiently from base line 6.87 +/- 1.88 (SE) ml/h to maximum value of 9.77 +/- 1.27 at 15 min following the LTD4 infusion. The maximum increase in Qlym was associated with an increase in the estimated pulmonary capillary pressure. The increase in Qlym was not associated with a change in the lymph-to-plasma protein concentration (L/P) ratio. Thromboxane synthetase inhibition with @entity6 (an @entity5 derivative) prevented @entity4 generation after LTD4 and also prevented the increases in pulmonary vascular pressures and Qlym. We conclude that LTD4 in awake @entity1 increases resistance of large pulmonary veins. The small transient increase in Qlym can be explained by the increase in pulmonary capillary pressure. @entity3 appears to mediate both the pulmonary hemodynamic and lymph responses to LTD4 in @entity1 .

title: Pulmonary vascular response to leukotriene D4 in unanesthetized @entity1 : role of XXXX .

answer: @entity3


abstract: The @entity1 dislocated or subluxated hip in the @entity0 with @entity2 presents a difficult problem in management. Twenty-three @entity0 with @entity2 who had a @entity1 subluxated or dislocated hip with degenerative changes were operated on at The Hospital for Special Surgery. Eight @entity0 had a unilateral hip arthrodesis. Six had a successful arthrodesis initially, resulting in relief of @entity1 and return to the preoperative functional level. A @entity4 developed in two @entity0 , but both had successful revision surgery, one by a second arthrodesis and the other by a total hip replacement. Thirteen of the fifteen @entity0 with a total hip replacement were @entity1 -free and functioning at a level consistent with their over-all involvement. One @entity0 had migration of the greater trochanter and slight bending of the femoral component, with persistent @entity1 . A second @entity0 had progressive @entity5 over a period of seven years, but continued to walk with minimum @entity1 . Two @entity0 had a recurrent dislocation, one requiring revision of the femoral component and the other, of the acetabular component. We think that the presence of @entity2 , even in the @entity0 with severe involvement, is not a contraindication for either a hip arthrodesis or a total hip replacement for a @entity1 deformed or degenerated hip. These @entity0 should be treated for the @entity1 in the hip, and the presence of the underlying @entity6 should not deter the appropriate treatment. For unilateral @entity3 in @entity0 who are unable to walk and in young, active @entity0 , we recommend hip fusion.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The treatment of the XXXX hip in @entity2 by total hip replacement or hip arthrodesis.

answer: @entity1


abstract: The @entity1 dislocated or subluxated hip in the @entity0 with @entity2 presents a difficult problem in management. Twenty-three @entity0 with @entity2 who had a @entity1 subluxated or dislocated hip with degenerative changes were operated on at The Hospital for Special Surgery. Eight @entity0 had a unilateral hip arthrodesis. Six had a successful arthrodesis initially, resulting in relief of @entity1 and return to the preoperative functional level. A @entity4 developed in two @entity0 , but both had successful revision surgery, one by a second arthrodesis and the other by a total hip replacement. Thirteen of the fifteen @entity0 with a total hip replacement were @entity1 -free and functioning at a level consistent with their over-all involvement. One @entity0 had migration of the greater trochanter and slight bending of the femoral component, with persistent @entity1 . A second @entity0 had progressive @entity5 over a period of seven years, but continued to walk with minimum @entity1 . Two @entity0 had a recurrent dislocation, one requiring revision of the femoral component and the other, of the acetabular component. We think that the presence of @entity2 , even in the @entity0 with severe involvement, is not a contraindication for either a hip arthrodesis or a total hip replacement for a @entity1 deformed or degenerated hip. These @entity0 should be treated for the @entity1 in the hip, and the presence of the underlying @entity6 should not deter the appropriate treatment. For unilateral @entity3 in @entity0 who are unable to walk and in young, active @entity0 , we recommend hip fusion.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The treatment of the @entity1 hip in XXXX by total hip replacement or hip arthrodesis.

answer: @entity2


abstract: The increasing therapeutic use of @entity4 metal binding agents, such as @entity6 ( @entity2 ), has stimulated the need for a sensitive and selective method for their determination in biological fluids. A method has now been developed in which @entity2 was converted to a highly fluorescent and stable derivative by reaction with @entity3 in aqueous solution at pH 8.3. The reaction was complete within 5 min. The derivative was separated by ion-pair reversed-phase column liquid chromatography. The mass spectrum of the derivative showed that two @entity3 molecules reacted with one @entity2 molecule. This method is also applicable to the determination of other @entity5 . The detection limit for @entity2 in urine is 10 pmol per 20-microliters injection and the precision is 7.4% at the 100-pmol level. The fluorescence response was linear from 1 to 400 micron. This method was used to determine @entity2 in the urine of @entity0 treated with this metal binding agent. In addition, total @entity2 was determined by adding @entity1 to the same urine to reduce biotransformed and oxidized @entity2 .

title: Fluorometric determination of XXXX and other @entity5 by precolumn derivatization with @entity3 and column liquid chromatography.

answer: @entity6


abstract: The increasing therapeutic use of @entity4 metal binding agents, such as @entity6 ( @entity2 ), has stimulated the need for a sensitive and selective method for their determination in biological fluids. A method has now been developed in which @entity2 was converted to a highly fluorescent and stable derivative by reaction with @entity3 in aqueous solution at pH 8.3. The reaction was complete within 5 min. The derivative was separated by ion-pair reversed-phase column liquid chromatography. The mass spectrum of the derivative showed that two @entity3 molecules reacted with one @entity2 molecule. This method is also applicable to the determination of other @entity5 . The detection limit for @entity2 in urine is 10 pmol per 20-microliters injection and the precision is 7.4% at the 100-pmol level. The fluorescence response was linear from 1 to 400 micron. This method was used to determine @entity2 in the urine of @entity0 treated with this metal binding agent. In addition, total @entity2 was determined by adding @entity1 to the same urine to reduce biotransformed and oxidized @entity2 .

title: Fluorometric determination of @entity6 and other XXXX by precolumn derivatization with @entity3 and column liquid chromatography.

answer: @entity5


abstract: The increasing therapeutic use of @entity4 metal binding agents, such as @entity6 ( @entity2 ), has stimulated the need for a sensitive and selective method for their determination in biological fluids. A method has now been developed in which @entity2 was converted to a highly fluorescent and stable derivative by reaction with @entity3 in aqueous solution at pH 8.3. The reaction was complete within 5 min. The derivative was separated by ion-pair reversed-phase column liquid chromatography. The mass spectrum of the derivative showed that two @entity3 molecules reacted with one @entity2 molecule. This method is also applicable to the determination of other @entity5 . The detection limit for @entity2 in urine is 10 pmol per 20-microliters injection and the precision is 7.4% at the 100-pmol level. The fluorescence response was linear from 1 to 400 micron. This method was used to determine @entity2 in the urine of @entity0 treated with this metal binding agent. In addition, total @entity2 was determined by adding @entity1 to the same urine to reduce biotransformed and oxidized @entity2 .

title: Fluorometric determination of @entity6 and other @entity5 by precolumn derivatization with XXXX and column liquid chromatography.

answer: @entity3


abstract: Of the 90 cases of @entity3 surgically treated in our department over the last decade (1975-1985), ten cases had a mediastinal @entity13 . In only two of these @entity0 was a median sternotomy required for excision of the mediastinal @entity6 . Three of the ten @entity0 underwent the initial operation in other institutions, having undergone a previous neck exploration. There were seven males and three females, ages ranging from 41-68 years. Six @entity0 had @entity9 , four had both @entity8 and @entity1 and two had @entity14 . One of them was operated on as an emergency because of @entity11 crisis with @entity4 levels of 15/16 mg%. Four @entity0 were asymptomatic and had @entity10 detected by @entity15 screening. The @entity4 level ranged from 11.5-16.2 mg%. The @entity12 ranged from 1.6-2.8 mg% with a mean of 2.0 mg%. All ten @entity0 had plasma @entity5 determination by radioimmunoassay, the values ranged from 1.5-3 times normal. In seven of the ten cases, the mediastinal @entity13 was localized within the thymus, the other three were adjacent to the great vessels, two to the aortic arch and one to the pulmonary artery-size ranging from 1.2-5.4 cm. Preoperative localization techniques: venous sampling in four cases; @entity7 scanning in three cases. No preoperative localization techniques were used in the other three cases. There was no mortality nor other significant @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX due to mediastinal @entity13 .

answer: @entity3


abstract: Of the 90 cases of @entity3 surgically treated in our department over the last decade (1975-1985), ten cases had a mediastinal @entity13 . In only two of these @entity0 was a median sternotomy required for excision of the mediastinal @entity6 . Three of the ten @entity0 underwent the initial operation in other institutions, having undergone a previous neck exploration. There were seven males and three females, ages ranging from 41-68 years. Six @entity0 had @entity9 , four had both @entity8 and @entity1 and two had @entity14 . One of them was operated on as an emergency because of @entity11 crisis with @entity4 levels of 15/16 mg%. Four @entity0 were asymptomatic and had @entity10 detected by @entity15 screening. The @entity4 level ranged from 11.5-16.2 mg%. The @entity12 ranged from 1.6-2.8 mg% with a mean of 2.0 mg%. All ten @entity0 had plasma @entity5 determination by radioimmunoassay, the values ranged from 1.5-3 times normal. In seven of the ten cases, the mediastinal @entity13 was localized within the thymus, the other three were adjacent to the great vessels, two to the aortic arch and one to the pulmonary artery-size ranging from 1.2-5.4 cm. Preoperative localization techniques: venous sampling in four cases; @entity7 scanning in three cases. No preoperative localization techniques were used in the other three cases. There was no mortality nor other significant @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity3 due to mediastinal XXXX .

answer: @entity13


abstract: UNASSIGNED: Recent studies showed that a positive microbiological result from sonication of the @entity2 spacer was associated with poor outcome of @entity0 , but no quantitative analysis has yet been performed. For this purpose, a prospective analysis of 50 spacers (46 @entity0 ) was performed. All spacers were processed according to a previously described protocol, including centrifugation and quantitative culture. Clinical data and outcome were also analysed. A statistical relationship between the results of the cultures and the outcome of the @entity0 was assessed. Sixteen @entity0 were diagnosed with @entity1 . Thirteen out of 50 spacers gave a positive culture. Nine of 13 presented with growth of an organism not isolated in the first-stage cultures, and in 7 out of 13 the organisms count was high (>10,000  CFU/ml). We have detected a significant statistical relationship between poor outcome and positive cultures, high colony counts, isolation of different organisms, positive periprosthetic cultures and @entity1 . The detection in a sonicated, antibiotic-loaded @entity2 spacer of organisms other than those isolated in the first surgical samples or high colony counts of any organisms is diagnostic with regard to @entity1 .

title: Diagnosis of XXXX using quantitative cultures from sonicated antibiotics-loaded spacers: implications for the clinical outcome.

answer: @entity1


abstract: Fifty-eight @entity1 conservatively treated for T1 @entity0 are analyzed for cosmetic outcome; 17 had concomitant adjuvant combination chemotherapy ( @entity4 , @entity3 , 5 @entity5 ). The results are evaluated by clinical criteria and a quantitative measurement by use of light field projection at 33 months median follow-up. Surgery consisted of lumpectomy and axillary dissection; radiotherapy was given to the breast only except for additional internal mammary irradiation in central and medial lesions. (50 Gy whole breast, 64 Gy electron/photon boost). Questionnaires are used for inquiry on @entity1 experience: 88% of the @entity1 experienced a good to excellent cosmetic outcome. According to the panel only 64% show a good to excellent cosmesis. Panel-scores on asymmetry are compared with quantitative measurements. More @entity6 and probably a higher degree of @entity2 in the boost area is found in the chemotherapy group. No differences in cosmetic outcome, complication rates, and @entity1 experiences are seen. Results are compared with published data.

title: Conservative XXXX treatment: analysis of cosmetic results and the role of concomitant adjuvant chemotherapy.

answer: @entity0


abstract: BACKGROUND: The authors used a large community sample of @entity1 (MA) users to verify the patterns and severity of @entity4 and establish a hierarchy of caries susceptibility by tooth type and tooth surface. METHODS: Using a stratified sampling approach, 571 MA users received comprehensive oral examinations and psychosocial assessments. Three calibrated dentists characterized @entity2 by using National Health and Nutrition Examination Survey protocols. The authors also collected data on substance use history and other attributes linked to @entity4 . RESULTS: On all dental outcome measures, MA users evidenced high @entity2 , with older (>=  30 years) and moderate or heavy MA users disproportionately affected. @entity0 had higher rates of @entity3 and caries, as well as a greater prevalence of anterior caries. Current cigarette smokers were more likely to manifest 5 or more anterior surfaces with untreated caries and 3 or more teeth with root caries. Nearly 3% were edentulous, and a significant percentage (40%) indicated embarrassment with their dental appearance. CONCLUSIONS: MA users have high rates of @entity2 and manifest a dose-response relationship, with greater levels of MA use associated with higher rates of @entity4 . @entity0 and current cigarette smokers are affected disproportionately. The intraoral patterns and hierarchy of caries susceptibility in MA users are distinctive. PRACTICAL IMPLICATIONS: The prevalence and patterns of @entity2 could be used to alert dentists to possible covert MA use and to plan treatment. Concerns about dental appearance have potential as triggers for behavioral interventions.

title: @entity4 patterns in XXXX users: Findings in a large urban sample.

answer: @entity1


abstract: BACKGROUND: The authors used a large community sample of @entity1 (MA) users to verify the patterns and severity of @entity4 and establish a hierarchy of caries susceptibility by tooth type and tooth surface. METHODS: Using a stratified sampling approach, 571 MA users received comprehensive oral examinations and psychosocial assessments. Three calibrated dentists characterized @entity2 by using National Health and Nutrition Examination Survey protocols. The authors also collected data on substance use history and other attributes linked to @entity4 . RESULTS: On all dental outcome measures, MA users evidenced high @entity2 , with older (>=  30 years) and moderate or heavy MA users disproportionately affected. @entity0 had higher rates of @entity3 and caries, as well as a greater prevalence of anterior caries. Current cigarette smokers were more likely to manifest 5 or more anterior surfaces with untreated caries and 3 or more teeth with root caries. Nearly 3% were edentulous, and a significant percentage (40%) indicated embarrassment with their dental appearance. CONCLUSIONS: MA users have high rates of @entity2 and manifest a dose-response relationship, with greater levels of MA use associated with higher rates of @entity4 . @entity0 and current cigarette smokers are affected disproportionately. The intraoral patterns and hierarchy of caries susceptibility in MA users are distinctive. PRACTICAL IMPLICATIONS: The prevalence and patterns of @entity2 could be used to alert dentists to possible covert MA use and to plan treatment. Concerns about dental appearance have potential as triggers for behavioral interventions.

title: XXXX patterns in @entity1 users: Findings in a large urban sample.

answer: @entity4


abstract: OBJECTIVE: We have recently reported that, in healthy elderly Dutch individuals, a @entity6 polymorphism in the @entity5 ( @entity5 ) gene is associated with higher sensitivity to low-dose @entity3 (0.25 mg), evaluated as both @entity4 suppression and insulin response, and with an increased body mass index (BMI). In the present study we investigated the role of the @entity6 polymorphism, and a BclI restriction site polymorphism in a group of Italian @entity0 with severe @entity1 . DESIGN: Two hundred and seventy-nine @entity0 (mean BMI 45.9 +/- 0.9 kg/m2) were genotyped using both PCR-restriction fragment length polymorphism analysis and Taqman Sequence Detection System. Determination of several metabolic and antropometric parameters was also performed in order to correlate them to the genotype. RESULTS: In this group of @entity1 @entity0 , 13 subjects (eight female, five males) were heterozygous for the @entity6 variant (allelic frequency 2.3%) and had significantly higher BMI (P < 0.04), resting energy expenditure (P < 0.03) and food intake (P < 0.01) when compared to wild-type homozygotes. When the data were analysed according to sex, female heterozygotes for the @entity6 allele had significantly higher BMI (P = 0.04), resting energy expenditure (P = 0.03) and food intake (P = 0.008) than @entity1 @entity0 with the wild-type 363 GR gene. Male carriers of this variant also had higher values for these variables although the differences did not reach statistical significance. A case-control study with homozygous wild-type @entity1 subjects which were age-, sex- and BMI-matched, revealed no difference in resting energy expenditure and food intake. The allele frequency of the BclI variant was 27% (89 females and 41 males out of 269 subjects). No differences in anthropometric and metabolic parameters were found between subjects heterozygous or homozygous for this variant @entity5 in this @entity1 population. However, when we studied the effect of the presence of the BclI polymorphism and the @entity6 variant in the same individual, we found that the subjects who carried both polymorphisms had a tendency towards higher systolic and diastolic blood pressure and significantly higher total and LDL- @entity2 levels (P = 0.005 and P = 0.05, respectively). DISCUSSION: Taking the results of this study and those obtained in the Dutch population, we speculate that heterozygous carriers of the @entity6 variant who develop @entity1 , may become even more @entity1 , possibly because they have a hypersensitive insulin response and thus, via activation of lipogenesis, store fat more efficiently. Furthermore, these data suggest that @entity6 carriers who carry the BclI polymorphism as well, tend to have a slightly unfavourable cardiovascular profile.

title: The relation between two polymorphisms in the @entity5 gene and body mass index, blood pressure and @entity2 in XXXX @entity0 .

answer: @entity1


abstract: OBJECTIVE: We have recently reported that, in healthy elderly Dutch individuals, a @entity6 polymorphism in the @entity5 ( @entity5 ) gene is associated with higher sensitivity to low-dose @entity3 (0.25 mg), evaluated as both @entity4 suppression and insulin response, and with an increased body mass index (BMI). In the present study we investigated the role of the @entity6 polymorphism, and a BclI restriction site polymorphism in a group of Italian @entity0 with severe @entity1 . DESIGN: Two hundred and seventy-nine @entity0 (mean BMI 45.9 +/- 0.9 kg/m2) were genotyped using both PCR-restriction fragment length polymorphism analysis and Taqman Sequence Detection System. Determination of several metabolic and antropometric parameters was also performed in order to correlate them to the genotype. RESULTS: In this group of @entity1 @entity0 , 13 subjects (eight female, five males) were heterozygous for the @entity6 variant (allelic frequency 2.3%) and had significantly higher BMI (P < 0.04), resting energy expenditure (P < 0.03) and food intake (P < 0.01) when compared to wild-type homozygotes. When the data were analysed according to sex, female heterozygotes for the @entity6 allele had significantly higher BMI (P = 0.04), resting energy expenditure (P = 0.03) and food intake (P = 0.008) than @entity1 @entity0 with the wild-type 363 GR gene. Male carriers of this variant also had higher values for these variables although the differences did not reach statistical significance. A case-control study with homozygous wild-type @entity1 subjects which were age-, sex- and BMI-matched, revealed no difference in resting energy expenditure and food intake. The allele frequency of the BclI variant was 27% (89 females and 41 males out of 269 subjects). No differences in anthropometric and metabolic parameters were found between subjects heterozygous or homozygous for this variant @entity5 in this @entity1 population. However, when we studied the effect of the presence of the BclI polymorphism and the @entity6 variant in the same individual, we found that the subjects who carried both polymorphisms had a tendency towards higher systolic and diastolic blood pressure and significantly higher total and LDL- @entity2 levels (P = 0.005 and P = 0.05, respectively). DISCUSSION: Taking the results of this study and those obtained in the Dutch population, we speculate that heterozygous carriers of the @entity6 variant who develop @entity1 , may become even more @entity1 , possibly because they have a hypersensitive insulin response and thus, via activation of lipogenesis, store fat more efficiently. Furthermore, these data suggest that @entity6 carriers who carry the BclI polymorphism as well, tend to have a slightly unfavourable cardiovascular profile.

title: The relation between two polymorphisms in the @entity5 gene and body mass index, blood pressure and XXXX in @entity1 @entity0 .

answer: @entity2


abstract: OBJECTIVE: We have recently reported that, in healthy elderly Dutch individuals, a @entity6 polymorphism in the @entity5 ( @entity5 ) gene is associated with higher sensitivity to low-dose @entity3 (0.25 mg), evaluated as both @entity4 suppression and insulin response, and with an increased body mass index (BMI). In the present study we investigated the role of the @entity6 polymorphism, and a BclI restriction site polymorphism in a group of Italian @entity0 with severe @entity1 . DESIGN: Two hundred and seventy-nine @entity0 (mean BMI 45.9 +/- 0.9 kg/m2) were genotyped using both PCR-restriction fragment length polymorphism analysis and Taqman Sequence Detection System. Determination of several metabolic and antropometric parameters was also performed in order to correlate them to the genotype. RESULTS: In this group of @entity1 @entity0 , 13 subjects (eight female, five males) were heterozygous for the @entity6 variant (allelic frequency 2.3%) and had significantly higher BMI (P < 0.04), resting energy expenditure (P < 0.03) and food intake (P < 0.01) when compared to wild-type homozygotes. When the data were analysed according to sex, female heterozygotes for the @entity6 allele had significantly higher BMI (P = 0.04), resting energy expenditure (P = 0.03) and food intake (P = 0.008) than @entity1 @entity0 with the wild-type 363 GR gene. Male carriers of this variant also had higher values for these variables although the differences did not reach statistical significance. A case-control study with homozygous wild-type @entity1 subjects which were age-, sex- and BMI-matched, revealed no difference in resting energy expenditure and food intake. The allele frequency of the BclI variant was 27% (89 females and 41 males out of 269 subjects). No differences in anthropometric and metabolic parameters were found between subjects heterozygous or homozygous for this variant @entity5 in this @entity1 population. However, when we studied the effect of the presence of the BclI polymorphism and the @entity6 variant in the same individual, we found that the subjects who carried both polymorphisms had a tendency towards higher systolic and diastolic blood pressure and significantly higher total and LDL- @entity2 levels (P = 0.005 and P = 0.05, respectively). DISCUSSION: Taking the results of this study and those obtained in the Dutch population, we speculate that heterozygous carriers of the @entity6 variant who develop @entity1 , may become even more @entity1 , possibly because they have a hypersensitive insulin response and thus, via activation of lipogenesis, store fat more efficiently. Furthermore, these data suggest that @entity6 carriers who carry the BclI polymorphism as well, tend to have a slightly unfavourable cardiovascular profile.

title: The relation between two polymorphisms in the XXXX gene and body mass index, blood pressure and @entity2 in @entity1 @entity0 .

answer: @entity5


abstract: OBJECTIVE: We have recently reported that, in healthy elderly Dutch individuals, a @entity6 polymorphism in the @entity5 ( @entity5 ) gene is associated with higher sensitivity to low-dose @entity3 (0.25 mg), evaluated as both @entity4 suppression and insulin response, and with an increased body mass index (BMI). In the present study we investigated the role of the @entity6 polymorphism, and a BclI restriction site polymorphism in a group of Italian @entity0 with severe @entity1 . DESIGN: Two hundred and seventy-nine @entity0 (mean BMI 45.9 +/- 0.9 kg/m2) were genotyped using both PCR-restriction fragment length polymorphism analysis and Taqman Sequence Detection System. Determination of several metabolic and antropometric parameters was also performed in order to correlate them to the genotype. RESULTS: In this group of @entity1 @entity0 , 13 subjects (eight female, five males) were heterozygous for the @entity6 variant (allelic frequency 2.3%) and had significantly higher BMI (P < 0.04), resting energy expenditure (P < 0.03) and food intake (P < 0.01) when compared to wild-type homozygotes. When the data were analysed according to sex, female heterozygotes for the @entity6 allele had significantly higher BMI (P = 0.04), resting energy expenditure (P = 0.03) and food intake (P = 0.008) than @entity1 @entity0 with the wild-type 363 GR gene. Male carriers of this variant also had higher values for these variables although the differences did not reach statistical significance. A case-control study with homozygous wild-type @entity1 subjects which were age-, sex- and BMI-matched, revealed no difference in resting energy expenditure and food intake. The allele frequency of the BclI variant was 27% (89 females and 41 males out of 269 subjects). No differences in anthropometric and metabolic parameters were found between subjects heterozygous or homozygous for this variant @entity5 in this @entity1 population. However, when we studied the effect of the presence of the BclI polymorphism and the @entity6 variant in the same individual, we found that the subjects who carried both polymorphisms had a tendency towards higher systolic and diastolic blood pressure and significantly higher total and LDL- @entity2 levels (P = 0.005 and P = 0.05, respectively). DISCUSSION: Taking the results of this study and those obtained in the Dutch population, we speculate that heterozygous carriers of the @entity6 variant who develop @entity1 , may become even more @entity1 , possibly because they have a hypersensitive insulin response and thus, via activation of lipogenesis, store fat more efficiently. Furthermore, these data suggest that @entity6 carriers who carry the BclI polymorphism as well, tend to have a slightly unfavourable cardiovascular profile.

title: The relation between two polymorphisms in the @entity5 gene and body mass index, blood pressure and @entity2 in @entity1 XXXX .

answer: @entity0


abstract: OBJECTIVE: To assess the validity of the @entity2 ( @entity2 )-based quality indicator, " @entity1 without treatment," and examine whether a nonphysician-based educational intervention can improve the accuracy of @entity2 questions regarding @entity1 and its treatment. SUBJECTS: All residents of a 538-bed urban, university affiliated, long-term-care (LTC) facility. Nursing and social work staff involved in completing the mood and behavior items on the @entity2 . DESIGN: Two retrospective chart review of psychotropic medications, @entity0 diagnoses, mental health evaluation, and treatment of all residents who were identified as displaying the @entity2 quality indicator, @entity1 without treatment, before and 2 months after an educational intervention. The education consisted of three 1 1/2-hour sessions led by a @entity0 clinical nurse specialist to educate registered nurse assessment coordinators and social workers about psychotropic medications, clinical characteristics of @entity0 diagnoses, chart review, and coordination of resident medical care. RESULTS: The first @entity2 identified 66 residents as having @entity1 without treatment. Clinical record review revealed that 11 of these residents were receiving an antidepressant. Twenty-two others were receiving a psychotropic medication consistent with their @entity0 diagnosis. Twenty-five of the remaining residents had not received mental health assessment for greater than 1 year. Two months after the educational intervention, 36 residents were identified as @entity1 without treatment. Four of these residents were receiving an antidepressant; eight others were receiving a psychotropic medication consistent with their @entity0 diagnosis. Thirteen of the remaining residents had not received mental health assessment for greater than 1 year. CONCLUSIONS: This preliminary study reveals that the presence of the quality indicator, @entity1 without treatment, may not accurately capture clinically depressed LTC residents in need of mental health intervention. An educational intervention may be able to assist staff in more accurately completing @entity2 questions regarding @entity1 and its treatment.

title: Challenging the quality of the quality indicator, " XXXX without treatment".

answer: @entity1


abstract: OBJECTIVE: To compare the costs associated with caring for severely demented residents nursing homes with and without feeding tubes. DESIGN: Retrospective cohort study. SETTING: A 700-bed long-term care facility in Boston @entity0 : Nursing home residents aged 65 years and over with advanced @entity1 and eating problems for whom long-term feeding tube had been discussed as a treatment option. MEASUREMENTS: Costs were compared over the 6 months that followed the tube-feeding decision for those residents who did and did not undergo feeding tube placement for the following items: nursing time, physician assessments, food, hospitalizations, emergency room visits, diagnostic tests, treatment with antibiotics and parenteral hydration, and feeding tube insertion. RESULTS: Twenty-two subjects were included, 11 were tube-fed (mean age 84.3 years +/- 6.0) and 11 were hand-fed (mean age 90.2 years +/- 9.1). The daily costs of nursing home care were higher for the residents without feeding tubes compared with residents with tubes ( 4219 +/- 1546 vs  2379 +/- 1032, P = 0.006). Nonetheless, Medicaid reimbursement to nursing homes in at least 26 states is higher for demented residents who are tube-fed than for residents with similar deficits who are not tube-fed. Costs typically billed to Medicare were greater for the tube-fed @entity0 ( 6994 +/- 5790 vs.  959 +/- 591, P < 0.001), primarily because of the high costs associated with initial feeding tube placement and hospitalizations or @entity2 for the management of complications of tube-feeding. CONCLUSIONS: Nursing homes are faced with a potential fiscal incentive to tube-feed residents with advanced @entity1 : tube-fed residents generate a higher daily reimbursement rate from Medicaid, yet require less expensive nursing home care. From a Medicare perspective, tube-fed @entity0 are expensive due to the high costs associated with feeding tube placement and acute management of complications. Further work is needed to determine whether these potential financial incentives influence tube-feeding decisions in practice.

title: Tube-feeding versus hand-feeding nursing home residents with advanced XXXX : a cost comparison.

answer: @entity1


abstract: Pulmonary valve (PV) @entity3 ( @entity3 ) is a rare entity, accounting for 1.5% to 2% of cases of @entity3 . Published data are limited to a few case series and reports. We sought to review the Mayo Clinic experience and describe clinical, echocardiographic, and microbiologic features. We included all @entity0 aged >= 18  years seen from 2000 to 2014 who had a diagnosis of native PV @entity3 and unequivocal echocardiographic involvement of the PV. Nine @entity0 with PV @entity3 were identified. Isolated PV @entity3 was present in 7 (78%) of 9 cases. The median age was 59  years and 22% were @entity0 . Three @entity0 had @entity1 , 2 had central venous catheters, and 3 had cardiovascular implantable electronic devices. Five @entity0 (56%) received chronic immunosuppressive therapy. @entity2 and viridans group streptococci were the most common pathogens, isolated in 22% of cases each. Transthoracic echocardiogram (TTE) and transesophageal echocardiogram (TEE) were done in 6 and 7 @entity0 , respectively. Four @entity0 underwent both procedures. TTE was diagnostic in all cases, but TEE failed to detect PV involvement in 1 @entity0 . Median follow-up was 1.8  years. Five @entity0 (56%) underwent PV replacement. There were no operative deaths. One @entity0 had @entity4 during follow-up, unrelated to his PV @entity3 episode. Our results suggest that PV @entity3 is rare but carries significant morbidity. TTE and TEE provide complementary information with TEE providing better visualization of other @entity1 . Our findings of a high prevalence of immunosuppressive therapy and cardiovascular implantable electronic devices have not been previously reported and deserve further investigation.

title: XXXX Involving the Pulmonary Valve.

answer: @entity3


abstract: BACKGROUND: @entity0 with @entity1 ( @entity1 ) often require tailored healthcare and support packages that develop as the disease progresses. The Client Service Receipt Inventory (CSRI) gathers retrospective information on service utilization. This study investigated the use of formal services and informal care as measured by the CSRI and explored associations between informal care, disease severity and functional ability as measured by the Unified @entity1 Rating Scale Total Motor Score (UHDRS-TMS) and functional scales. METHODS: All monitored longitudinal data from annual clinical assessments of UHDRS-TMS and functional assessments and CSRI collected under the auspices of the European @entity1 Network (EHDN) REGISTRY study between the years 2004 and 2009 were utilised in the analyses. Disease severity was reflected by UHDRS-TMS. Functional ability was measured using the UHDRS functional scales. CSRI data were analysed according to percentage use of individual formal services and total estimated hours per week of informal care. Regression analyses were conducted to identify any associations between disease severity, functional ability and hours of informal care. RESULTS: 451 @entity1 @entity0 (212 female; 239 male) completed one visit; 105 @entity0 (54 females; 51 males) completed two visits and 47 @entity0 (20 females; 27 males) completed three visits in total over the 5 year period. The mean time between visits was 1.2 years. At visit one, 74% of the @entity0 reported being in receipt of at least one formal hospital-based service in the previous six months, and 89% reported receipt of formal primary and community care services. In contrast, at the third visit, 62% of @entity0 had used hospital based services and 94% formal community based services in the previous six months. Fifty % of individuals required some form of informal care in the home at visit 1; this increased to 68% at visits 2 and 3. The mean (SD) estimated weekly total informal care hours at visits 1, 2 and 3 were 32.8 (49.4); 21.6 (53.6) and 21.3 (62.4) respectively. Only the scores on the Functional Assessment Scale (FAS) accounted for the variance in the weekly total informal care hours at each visit. CONCLUSIONS: Although it must be acknowledged that service use is supply driven, most @entity1 @entity0 across Europe surveyed as part of this study were in receipt of formal primary and community care services and to a lesser extent formal hospital based services. There was however a large reliance on informal care in the home. The FAS appear to have predictive value on informal care requirements and may have utility in facilitating pro-active service provision and in particular when managing carer burden in this population.

title: Utilisation of Healthcare and Associated Services in XXXX : a data mining study.

answer: @entity1


abstract: BACKGROUND: Presently, the impact of @entity1 size as a prognostic factor after curative liver resection (LR) for @entity3 ( @entity3 ) remains controversial. This study was performed to determine the prognostic factors of @entity0 undergoing LR for solitary @entity3 with special emphasis on the importance of @entity1 size. METHODS: Between 2000 and 2013, 560 @entity0 underwent curative LR for solitary primary @entity3 which met the study criteria. RESULTS: One-hundred and seventy-eight @entity0 underwent major hepatectomies and the overall in-hospital mortality was 2.0%. There were 282 @entity0 (50.4%) with @entity5 . The 5-year @entity4 ( @entity4 ) was 64% and @entity4 ( @entity4 ) was 50%, respectively. Multivariate analyses demonstrated that @entity2 , microvascular invasion and size were independent predictors of @entity4 and @entity2 , microvascular invasion and age were independent prognostic factors of @entity4 . Subset analysis demonstrated that @entity1 size was a prognostic factor for solitary @entity3 with microvascular invasion (AJCC T2) but not solitary @entity3 without microvascular invasion (AJCC T1). CONCLUSIONS: Size, microvascular invasion, and @entity2 are independent prognostic factors of @entity4 for solitary @entity3 after LR. @entity1 size is an important prognostic factor in T2 but not T1 solitary @entity1 . These findings suggest that the current AJCC TNM staging system may need to be revised. J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Importance of XXXX size as a prognostic factor after partial liver resection for @entity3 : Implications on the current AJCC staging system.

answer: @entity1


abstract: BACKGROUND: Presently, the impact of @entity1 size as a prognostic factor after curative liver resection (LR) for @entity3 ( @entity3 ) remains controversial. This study was performed to determine the prognostic factors of @entity0 undergoing LR for solitary @entity3 with special emphasis on the importance of @entity1 size. METHODS: Between 2000 and 2013, 560 @entity0 underwent curative LR for solitary primary @entity3 which met the study criteria. RESULTS: One-hundred and seventy-eight @entity0 underwent major hepatectomies and the overall in-hospital mortality was 2.0%. There were 282 @entity0 (50.4%) with @entity5 . The 5-year @entity4 ( @entity4 ) was 64% and @entity4 ( @entity4 ) was 50%, respectively. Multivariate analyses demonstrated that @entity2 , microvascular invasion and size were independent predictors of @entity4 and @entity2 , microvascular invasion and age were independent prognostic factors of @entity4 . Subset analysis demonstrated that @entity1 size was a prognostic factor for solitary @entity3 with microvascular invasion (AJCC T2) but not solitary @entity3 without microvascular invasion (AJCC T1). CONCLUSIONS: Size, microvascular invasion, and @entity2 are independent prognostic factors of @entity4 for solitary @entity3 after LR. @entity1 size is an important prognostic factor in T2 but not T1 solitary @entity1 . These findings suggest that the current AJCC TNM staging system may need to be revised. J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Importance of @entity1 size as a prognostic factor after partial liver resection for XXXX : Implications on the current AJCC staging system.

answer: @entity3


abstract: UNASSIGNED: Dairy @entity2 are high value farm animals requiring careful management to achieve the best results. Since the advent of robotic and high throughput milking, the traditional few minutes available for individual @entity0 attention daily has disappeared and new automated technologies have been applied to improve monitoring of dairy @entity2 production, nutrition, fertility, health and welfare. @entity2 milked by robots must meet legal requirements to detect healthy milk. This review focuses on emerging technical approaches in those areas of high cost to the farmer (fertility, @entity1 , @entity4 , @entity5 and calving). The availability of low cost tri-axial accelerometers and wireless telemetry has allowed accurate models of behaviour to be developed and sometimes combined with rumination activity detected by acoustic sensors to detect oestrus; other measures (milk and skin temperature, electronic noses, milk yield) have been abandoned. In-line biosensors have been developed to detect markers for ovulation, pregnancy, @entity3 , @entity4 and metabolic changes. Wireless telemetry has been applied to develop boluses for monitoring the rumen pH and temperature to detect @entity1 . Udder health requires a multisensing approach due to the varying inflammatory responses collectively described as @entity4 . Lameness can be detected by walk over weigh cells, but also by various types of video image analysis and speed measurement. Prediction and detection of calving time is an area of active research mostly focused on behavioural change.

title: Animal board invited review: precision livestock farming for dairy XXXX with a focus on oestrus detection.

answer: @entity2


abstract: Optic flow based navigation is a fundamental way of visual course control described in many different species including @entity0 . In the @entity1 , an essential part of optic flow analysis is performed in the lobula plate, a retinotopic map of motion in the environment. There, the so-called lobula plate tangential cells possess large receptive fields with different preferred directions in different parts of the visual field. Previous studies demonstrated an extensive connectivity between different tangential cells, providing, in principle, the structural basis for their large and complex receptive fields. We present a network simulation of the tangential cells, comprising most of the neurons studied so far (22 on each hemisphere) with all the known connectivity between them. On their dendrite, model neurons receive input from a retinotopic array of Reichardt-type motion detectors. Model neurons exhibit receptive fields much like their natural counterparts, demonstrating that the connectivity between the lobula plate tangential cells indeed can account for their complex receptive field structure. We describe the tuning of a model neuron to particular types of ego-motion (rotation as well as translation around/along a given body @entity2 ) by its 'action field'. As we show for model neurons of the vertical system (VS-cells), each of them displays a different type of action field, i.e., responds maximally when the @entity1 is rotating around a particular body @entity2 . However, the tuning width of the rotational action fields is relatively broad, comparable to the one with dendritic input only. The additional intra-lobula-plate connectivity mainly reduces their translational action field amplitude, i.e., their sensitivity to translational movements along any body @entity2 of the @entity1 .

title: Neural action fields for optic flow based navigation: a simulation study of the XXXX lobula plate network.

answer: @entity1


abstract: BACKGROUND: As a valuable medicinal plant, the yield of @entity6 is seriously affected by autotoxicity, which is a common phenomenon due to continuous cropping. However, the mechanism of autotoxicity in @entity6 is still unknown. RESULTS: In total, high throughput sequencing of 18 RNA-Seq libraries produced 996,000 000 100-nt reads that were assembled into 72,732 contigs. Compared with control, 3697 and 2828 genes were significantly up- and down-regulated across different tissues and time points, respectively. Gene Ontology enrichment analysis showed that 'enzyme inhibitor activity', 'carboxylesterase activity', 'pectinesterase activity', 'centrosome cycle and duplication' and 'mitotic spindle elongation' were enriched for the up-regulated genes. Transcription factors including AP2s/ERFs, MYBs, and WRKYs were up-regulated in roots after @entity8 treatment. Moreover, reactive @entity0 species, peroxidases and @entity1 dismutase contigs were up-regulated in roots after @entity8 treatment. Physiological and biochemical indexes showed that the @entity3 and @entity2 content were restored to lower levels at a later stage after @entity8 treatment. @entity8 inhibited the root hair development in a dose-dependent manner, and several differential expressed genes potentially involved in hair development were identified. Several key contigs in the @entity4 and @entity7 biosynthesis pathways were repressed. Finally, 58,518 @entity5 ( @entity5 ) events from 12,950 genes were found after @entity8 treatment. Interestingly, contigs in the @entity7 biosynthetic pathway underwent @entity5 , providing useful information about post-transcriptional regulation in @entity6 . CONCLUSIONS: This study revealed the stress-response molecular mechanisms in @entity6 induced by @entity8 .

title: Comprehensive characterization of a time-course transcriptional response induced by autotoxins in XXXX using RNA-Seq.

answer: @entity6


abstract: Recent studies reveal the role of the ankle retinacula in proprioception and functional stability of the ankle, but there is no clear evidence of their role in the outcomes of @entity3 . 25 @entity0 with outcomes of @entity3 were evaluated by MRI to analyze possible @entity1 . @entity0 with damage were subdivided into two groups: group A comprised cases with ankle retinacula damage only, and group B those also with anterior talofibular ligament rupture or @entity2 . Both groups were examined by VAS, CRTA and static posturography and underwent three treatments of deep connective tissue massage (Fascial Manipulation technique). All evaluations were repeated after the end of treatment and at 1, 3 and 6 months. At MRI, alteration of at least one of the ankle retinacula was evident in 21 subjects, and a further lesion was also identified in 7 subjects. After treatment, VAS and CRTA evaluations showed a statistically significant decrease in values with respect to those before treatment (p < 0.0001). There were also significant improvements (p < 0.05) in stabilometric platform results. No significant difference was found between groups A and B. The initial benefit was generally maintained at follow-up. The alteration of retinacula at MRI clearly corresponds to the proprioceptive damage revealed by static posturography and clinical examination. Treatment focused on the retinacula may improve clinical outcomes and stabilometric data.

title: RMI study and clinical correlations of ankle retinacula damage and outcomes of XXXX .

answer: @entity3


abstract: Cholecystectomy is one of the most common surgical procedures. @entity0 is by far the most common pathology of the gallbladder. Terms for describing @entity2 are numerous, thus there is no uniform terminology. One hundred cholecystectomies and 10 gallbladders from autopsies were reviewed and inflammatory changes were analyzed. @entity2 was seen in 75% of cases with epithelial metaplasia and 73% with regenerative epithelium, the latter being associated with erosion but not with the presence of @entity3 . Muscular thickening and adipose deposits were mostly mild. @entity0 was mild in 28%, moderatein 57%, and severe in 15%. Activity was found in 29% of cases. @entity1 was present in all cases: 26% mild, 62% moderate, and 12% severe. Autopsy cases did not show significant changes. A simple and reproducible scoring system of @entity0 and @entity1 of the gallbladder is proposed. Three numbers refer to mild, moderate, or severe degrees of @entity0 and activity, with a final score that results from adding both values. The @entity1 is classified in three different stages. The final report uses both values to classify the chronic @entity2 . A scoring system for chronic cholecystopathy to replace descriptive terms would give an exact transduction of the observed changes in an objective fashion that could not be misinterpreted by physicians or other pathologists.

title: Histologic analysis of chronic inflammatory patterns in the gallbladder: diagnostic criteria for reporting XXXX .

answer: @entity2


abstract: BACKGROUND: Previous studies have suggested that survival following surgery for @entity2 is better in @entity0 than @entity0 . However, the findings were inconsistent and few studies adjusted for case-mix. The aim of the present study was to establish whether there were gender differences in survival following surgery for @entity2 after adjusting for case-mix. METHODS: Some 3200 @entity0 who underwent resection for @entity2 between 1991 and 1994 in 11 hospitals in Scotland were included in the study. Five-year survival rates, and the corresponding hazard ratios, adjusted for age, mode of presentation, site of @entity1 , the nature of surgery and Dukes stage, were calculated for @entity0 and @entity0 . RESULTS: Overall survival at 5 years was higher in @entity0 than @entity0 , in those with @entity1 , those who underwent elective surgery and those who underwent apparently curative resection (all P < 0.001). Cancer-specific survival at 5 years was also higher in @entity0 (P = 0.008) and those who underwent elective surgery (P < 0.001). The adjusted hazard ratios, for @entity0 relative to @entity0 following curative resection, were 0.76 (95 per cent confidence interval (c.i.) 0.68 to 0.85) (P < 0.001) for overall survival and 0.84 (95 per cent c.i. 0.73 to 0.98) (P = 0.021) for @entity1 -specific survival. CONCLUSION: Following apparently curative resection for @entity2 and after adjusting for case-mix, there was an excess of both @entity1 -related and intercurrent deaths in @entity0 .

title: Male gender adversely affects survival following surgery for XXXX .

answer: @entity2


abstract: The present study represents an analysis of 96 @entity0 with @entity5 ( @entity5 ) treated in Seoul National University Hospital, Seoul, Korea between 1990 and 1999. Twenty-two @entity0 were treated by allogeneic bone marrow transplantation (BMT) from HLA identical sibling donors and 74 by immunosuppressive therapy (IS) with antithymocyte globulin (ATG) or antilymphocyte globulin (ALG). There was no statistical difference between the two treatment groups in age, sex, disease duration, and previous transfusion amount. In the BMT group, grade II-IV acute @entity4 ( @entity4 ) developed in 10% and chronic @entity4 occurred in 33% of @entity0 . Only one @entity0 died from complication of transplantation ( @entity6 ). Of 74 @entity0 who received IS treatment, 45% achieved a complete or partial response. Twenty @entity0 died among IS treatment group. Major causes of @entity1 were @entity3 (40%) and @entity2 (55%). In the BMT group, the 5-yr overall survival (OS) was 95% after a median follow-up of 42 months. In the IS group, the 5-yr OS was 70% after a median follow-up of 49 months (p=0.04). In conclusion, the long-term survival rates of @entity5 in Koreans receiving BMT or IS were excellent compared with the Western data. Further evaluation on the prognosis of @entity5 in Asians should be done.

title: The treatment of XXXX : outcomes of bone marrow transplantation and immunosuppressive therapy in a single institution of Korea.

answer: @entity5


abstract: Aberrant brain reward responses to food-related cues are an implied characteristic of @entity0 @entity1 ; yet, findings are inconsistent. To explain these inconsistencies, we aimed to uncover endophenotypes associated with heterogeneity in attributing incentive salience to food cues in the context of other emotionally salient cues; a phenomenon described as sign-vsgoal tracking in preclinical models. Data from 64 lean and 88 @entity1 adults who were 35.5        9.4 years old and predominantly @entity0 (79%) were analyzed. @entity0 viewed food-related, pleasant, neutral and unpleasant images while recording electroencephalograph. Late positive potentials were used to assess incentive salience attributed to the visual stimuli. Eating and affective traits were also assessed. Findings demonstrated that @entity1 individuals, in general, do not demonstrate aberrant brain reward responses to food-related cues. As hypothesized, latent profile analysis of the late positive potential uncovered two distinct groups. 'Sign-trackers' showed greater responses to food-related cues (P   <   0.001) but lower responses to pleasant stimuli (P   <   0.001) compared with 'goal-trackers'. There were proportionally more @entity1 than lean 'sign-trackers' (P   =   0.03). Obese 'sign-trackers' reported significantly higher levels of emotional eating and food craving (P   <   0.001). By examining the heterogeneity in brain reactivity to various emotional stimuli, this translational study highlights the need to consider important neurobehavioral endophenotypes of @entity1 .

title: Heterogeneity in brain reactivity to pleasant and food cues: evidence of sign-tracking in XXXX .

answer: @entity0


abstract: UNASSIGNED: Smoking cigarettes is a major risk factor in the development and progression of @entity4 ( @entity4 ) and @entity8 ( @entity8 ). Modified risk @entity6 products (MRTPs) are being developed to reduce smoking-related health risks. The goal of this study was to investigate hallmarks of @entity8 and @entity4 over an 8-month period in @entity14 -deficient @entity1 exposed to conventional cigarette smoke (CS) or to the aerosol of a candidate MRTP, THS2.2. In addition to chronic exposure, cessation or switching to THS2.2 after 2 months of CS exposure was assessed. Engaging a systems toxicology approach, exposure effects were investigated using physiology and histology combined with transcriptomics, lipidomics, and proteomics. CS induced @entity12 and @entity13 , @entity3 , and emphysematous changes ( @entity5 and @entity0 ). Atherogenic effects of CS exposure included altered lipid profiles and aortic plaque formation. Exposure to THS2.2 aerosol ( @entity9 concentration matched to CS, 29.9 mg/m(3)) did not induce @entity3 or @entity11 , nor did it consistently change the lipid profile or enhance the plaque area. Cessation or switching to THS2.2 reversed the inflammatory responses and halted progression of @entity10 . Biological processes, including senescence, @entity2 , and proliferation, were significantly impacted by CS, but not by THS2.2 aerosol. Both, cessation and switching to THS2.2 reduced these perturbations to almost sham exposure levels. In conclusion, in this @entity1 model cessation or switching to THS2.2 retarded the progression of CS-induced @entity7 and emphysematous changes, while THS2.2 aerosol alone had minimal adverse effects.

title: An 8-Month Systems Toxicology Inhalation/Cessation Study in XXXX -/- @entity1 to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk @entity6 Product, THS 2.2, Compared with Conventional Cigarettes.

answer: @entity14


abstract: UNASSIGNED: Smoking cigarettes is a major risk factor in the development and progression of @entity4 ( @entity4 ) and @entity8 ( @entity8 ). Modified risk @entity6 products (MRTPs) are being developed to reduce smoking-related health risks. The goal of this study was to investigate hallmarks of @entity8 and @entity4 over an 8-month period in @entity14 -deficient @entity1 exposed to conventional cigarette smoke (CS) or to the aerosol of a candidate MRTP, THS2.2. In addition to chronic exposure, cessation or switching to THS2.2 after 2 months of CS exposure was assessed. Engaging a systems toxicology approach, exposure effects were investigated using physiology and histology combined with transcriptomics, lipidomics, and proteomics. CS induced @entity12 and @entity13 , @entity3 , and emphysematous changes ( @entity5 and @entity0 ). Atherogenic effects of CS exposure included altered lipid profiles and aortic plaque formation. Exposure to THS2.2 aerosol ( @entity9 concentration matched to CS, 29.9 mg/m(3)) did not induce @entity3 or @entity11 , nor did it consistently change the lipid profile or enhance the plaque area. Cessation or switching to THS2.2 reversed the inflammatory responses and halted progression of @entity10 . Biological processes, including senescence, @entity2 , and proliferation, were significantly impacted by CS, but not by THS2.2 aerosol. Both, cessation and switching to THS2.2 reduced these perturbations to almost sham exposure levels. In conclusion, in this @entity1 model cessation or switching to THS2.2 retarded the progression of CS-induced @entity7 and emphysematous changes, while THS2.2 aerosol alone had minimal adverse effects.

title: An 8-Month Systems Toxicology Inhalation/Cessation Study in @entity14 -/- @entity1 to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk XXXX Product, THS 2.2, Compared with Conventional Cigarettes.

answer: @entity6


abstract: UNASSIGNED: Smoking cigarettes is a major risk factor in the development and progression of @entity4 ( @entity4 ) and @entity8 ( @entity8 ). Modified risk @entity6 products (MRTPs) are being developed to reduce smoking-related health risks. The goal of this study was to investigate hallmarks of @entity8 and @entity4 over an 8-month period in @entity14 -deficient @entity1 exposed to conventional cigarette smoke (CS) or to the aerosol of a candidate MRTP, THS2.2. In addition to chronic exposure, cessation or switching to THS2.2 after 2 months of CS exposure was assessed. Engaging a systems toxicology approach, exposure effects were investigated using physiology and histology combined with transcriptomics, lipidomics, and proteomics. CS induced @entity12 and @entity13 , @entity3 , and emphysematous changes ( @entity5 and @entity0 ). Atherogenic effects of CS exposure included altered lipid profiles and aortic plaque formation. Exposure to THS2.2 aerosol ( @entity9 concentration matched to CS, 29.9 mg/m(3)) did not induce @entity3 or @entity11 , nor did it consistently change the lipid profile or enhance the plaque area. Cessation or switching to THS2.2 reversed the inflammatory responses and halted progression of @entity10 . Biological processes, including senescence, @entity2 , and proliferation, were significantly impacted by CS, but not by THS2.2 aerosol. Both, cessation and switching to THS2.2 reduced these perturbations to almost sham exposure levels. In conclusion, in this @entity1 model cessation or switching to THS2.2 retarded the progression of CS-induced @entity7 and emphysematous changes, while THS2.2 aerosol alone had minimal adverse effects.

title: An 8-Month Systems Toxicology Inhalation/Cessation Study in @entity14 -/- XXXX to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk @entity6 Product, THS 2.2, Compared with Conventional Cigarettes.

answer: @entity1


abstract: UNASSIGNED: The aim of the present study was to determine the outcome of @entity0 undergoing pancreatic resection with (VR+) or without (VR-) mesenteric-portal vein resection for @entity3 . Between January 1998 and December 2012, 241 @entity0 with @entity2 underwent pancreatic resection: in 64 @entity0 , surgery included venous resection for macroscopic invasion of mesenteric-portal vein axis. Morbidity and mortality did not differ between the two groups (VR+: 29% and 3%; VR-: 30% and 4.0%, resp.). Radical resection was achieved in 55/64 (78%) in the VR+ group and in 126/177 (71%) in the VR- group. Vascular invasion was histologically proven in 44 (69%) of the VR+ group. Survival curves were not statistically different between the two groups. Mean and median survival time were 26 and 15 months, respectively, in VR- versus 20 and 14 months, respectively, in VR+ group (p = 0.52). In the VR+ group, only histologically proven vascular invasion significantly impacted survival (p = 0.02), while, in the VR- group, R0 resection (p = 0.001) and @entity1 's grading (p = 0.01) significantly influenced long-term survival. Vascular resection during pancreatectomy can be performed safely, with acceptable morbidity and mortality. Long-term survival was the same, with or without venous resection. Survival was worse for @entity0 with histologically confirmed vascular infiltration.

title: Mesenteric-Portal Vein Resection during Pancreatectomy for XXXX .

answer: @entity2


abstract: The diameter of the fibrils in the normal vitreous cortex at the ora serrata of @entity0 eyes was found to range from 10.8 to 12.4 nm. There is no significant increase in thickness with age. Periodic cross-striation typical for collagen could be demonstrated by microdensitometry. In @entity1 , secondary lateral aggregations of the fibrils are a common factor, usually in proximity to disintegrating cells. Disintegrating cells in the vitreous cortex were already observable in childhood. They were more often seen with increasing age. In a pathological case, acid phosphatase could be demonstrated both within the vitreous fibrocytes and in the extracellular space, released from disintegrating cells. Fibrils and segments of banded material were observed within pits and @entity2 , and in intracytoplasmic channels and vacuoles of the aged vitreous fibrocytes. Linear aggregations of @entity3 red-positive material were seen at the surface and within @entity2 of the same cells. The findings are interpreted as an indication for phagocytosis and--or secretion of collagen by the vitreous fibrocytes even in @entity1 .

title: Electron-microscopic study on the fibrillar network and fibrocyte--collagen interactions in the vitreous cortex at the ora serrata of XXXX eyes with special regard to the role of disintegrating cells.

answer: @entity0


abstract: Sixty-seven @entity0 with @entity7 ( @entity7 ) were analyzed clinically. Their mean age was 39.3 years, and 47 (70%) of them were male. Fifty (74.6%) showed @entity6 ( @entity6 ) initially and five (7.5%) had additionally chronic @entity3 . @entity2 was present in 27%. During the follow-up (mean 6.7 years) @entity1 occurred in four @entity0 12-151 (mean 84.2) months after the diagnosis of @entity7 . Four @entity0 died of non-renal causes. The actuarial life-table survival at 5, 10 and 15 years was 94%, 83% and 69%, respectively. To some extent renal function deteriorated in 13 @entity0 (19%). These @entity0 were older (49.9 vs. 36.8 years, p less than 0.01) than those with preserved renal function, and many of them had serum @entity5 levels of 125 mumol/l or more initially. Sex did not correlate with the development of @entity3 . @entity0 with slight @entity4 never showed @entity3 . The retrospective comparison of survival in @entity0 who did (N = 31) or did not (N = 19) receive corticosteroids and/or immunosuppressive drugs for the treatment of @entity6 revealed no evident difference at 5 or 10 years. This clinical analysis emphasizes the fairly favorable outcome of @entity0 with @entity7 . Hence a reserved view must be taken when treatment with potentially dangerous agents is considered in a disease with unknown etiology and pathogenesis.

title: Survival in XXXX .

answer: @entity7


abstract: @entity5 ( @entity5 ) in pregnancy is characterized by the presence of autoantibodies in association with recurrent fetal loss and severe complications such as @entity3 , @entity4 , or @entity6 . The most clinically important serologic markers are @entity7 , anticardiolipin antibodies, and recently anti-beta-2-glycoprotein 1 antibodies. At present, standardization does not exist and a definitive association between specific clinical manifestation and antibody level is not yet known. Experimental data gave evidence that passive transfer of antiphospholipid antibodies result in clinical manifestation of @entity5 , that is, fetal loss and @entity2 . Treatment with heparin, @entity1 , or intravenous immunoglobulins decreased the fetal loss rate. Treatment regimens in @entity0 are very difficult to interpret. Evidence from two prospective studies supported treatment with heparin and @entity1 to improve pregnancy outcome. The risk of @entity3 and @entity6 was substantial and occurred in 50% of @entity0 . The general failure rate of heparin/ @entity1 treatment is approximately 30%. In such cases intravenous immunoglobulin in combination with heparin and @entity1 has been used to treat @entity5 .

title: XXXX in obstetrics.

answer: @entity5


abstract: Nailfold capillary microscopy patterns in 22 @entity0 with @entity6 ( @entity6 ) were compared with those of 21 @entity0 with @entity5 ( @entity5 ) and 30 @entity0 with @entity3 ( @entity7 [ @entity7 ]). Microvascular data were classified blindly as follows: normal, @entity4 , @entity7 pattern, and @entity5 pattern, with special attention to the presence of @entity8 , branched "bushy" capillary formations. Of the 22 @entity0 with @entity6 , 63.6% had an @entity7 pattern, 22.7% had an @entity5 pattern, 13.6% had @entity4 , and 72.7% had bushy capillary formations. Compared with @entity5 , @entity6 exhibited significantly greater capillary loss (P less than 0.05), more frequent @entity7 patterns (P less than 0.001), and more frequent bushy capillaries (P less than 0.001). Compared with @entity7 @entity0 , @entity6 @entity0 displayed less frequent @entity7 patterns (P less than 0.02) and more frequent bushy capillary formations (P less than 0.01). The presence of bushy capillaries was suggestive of @entity6 . For diagnostic purposes, bushy capillaries displayed 72% sensitivity, 80% specificity, and 87.2% negative predictive value. The quantitative and qualitative expressions of @entity2 were different in @entity6 and @entity5 , respectively. This supports the hypothesis that @entity1 is a distinct entity. Nevertheless, there were many resemblances between @entity6 and @entity7 , which implies that @entity6 is possibly a clinical form of @entity7 .

title: Nailfold capillary microscopy in @entity6 . Comparison with @entity3 and XXXX .

answer: @entity5


abstract: Nailfold capillary microscopy patterns in 22 @entity0 with @entity6 ( @entity6 ) were compared with those of 21 @entity0 with @entity5 ( @entity5 ) and 30 @entity0 with @entity3 ( @entity7 [ @entity7 ]). Microvascular data were classified blindly as follows: normal, @entity4 , @entity7 pattern, and @entity5 pattern, with special attention to the presence of @entity8 , branched "bushy" capillary formations. Of the 22 @entity0 with @entity6 , 63.6% had an @entity7 pattern, 22.7% had an @entity5 pattern, 13.6% had @entity4 , and 72.7% had bushy capillary formations. Compared with @entity5 , @entity6 exhibited significantly greater capillary loss (P less than 0.05), more frequent @entity7 patterns (P less than 0.001), and more frequent bushy capillaries (P less than 0.001). Compared with @entity7 @entity0 , @entity6 @entity0 displayed less frequent @entity7 patterns (P less than 0.02) and more frequent bushy capillary formations (P less than 0.01). The presence of bushy capillaries was suggestive of @entity6 . For diagnostic purposes, bushy capillaries displayed 72% sensitivity, 80% specificity, and 87.2% negative predictive value. The quantitative and qualitative expressions of @entity2 were different in @entity6 and @entity5 , respectively. This supports the hypothesis that @entity1 is a distinct entity. Nevertheless, there were many resemblances between @entity6 and @entity7 , which implies that @entity6 is possibly a clinical form of @entity7 .

title: Nailfold capillary microscopy in @entity6 . Comparison with XXXX and @entity5 .

answer: @entity3


abstract: Nailfold capillary microscopy patterns in 22 @entity0 with @entity6 ( @entity6 ) were compared with those of 21 @entity0 with @entity5 ( @entity5 ) and 30 @entity0 with @entity3 ( @entity7 [ @entity7 ]). Microvascular data were classified blindly as follows: normal, @entity4 , @entity7 pattern, and @entity5 pattern, with special attention to the presence of @entity8 , branched "bushy" capillary formations. Of the 22 @entity0 with @entity6 , 63.6% had an @entity7 pattern, 22.7% had an @entity5 pattern, 13.6% had @entity4 , and 72.7% had bushy capillary formations. Compared with @entity5 , @entity6 exhibited significantly greater capillary loss (P less than 0.05), more frequent @entity7 patterns (P less than 0.001), and more frequent bushy capillaries (P less than 0.001). Compared with @entity7 @entity0 , @entity6 @entity0 displayed less frequent @entity7 patterns (P less than 0.02) and more frequent bushy capillary formations (P less than 0.01). The presence of bushy capillaries was suggestive of @entity6 . For diagnostic purposes, bushy capillaries displayed 72% sensitivity, 80% specificity, and 87.2% negative predictive value. The quantitative and qualitative expressions of @entity2 were different in @entity6 and @entity5 , respectively. This supports the hypothesis that @entity1 is a distinct entity. Nevertheless, there were many resemblances between @entity6 and @entity7 , which implies that @entity6 is possibly a clinical form of @entity7 .

title: Nailfold capillary microscopy in XXXX . Comparison with @entity3 and @entity5 .

answer: @entity6


abstract: In unanaesthetized @entity1 the most striking effects of @entity2 ( @entity2 ) consist of a marked @entity0 variability and a concomitant marked reduction in heart rate variability. Because the relative contribution of carotid and aortic baroreceptors to these phenomena has never been assessed, blood pressure (intra-arterial catheter) and heart rate were measured in unanaesthetized, unrestrained @entity1 for 8-10 h under three conditions: intact animals, 1 week after section of the carotid sinus or the aortic nerves and 1 week after @entity2 . Blood pressure and heart rate signals were analysed by a computer to provide mean values and variation coefficients of variation i.e. blood pressure and heart rate variabilities, for each recording period. In the intact @entity1 the coefficient of variation was 6.6 +/- 0.6% (mean +/- s.e.) for mean blood pressure and 11.2 +/- 1.7% for heart rate. The coefficient of variation for mean blood pressure was not altered by either the aortic or the carotid sinus nerve section, a marked increase being observed only after @entity2 (11.5 +/- 1.3%, P less than 0.01). On the other hand, the coefficient of variation for heart rate was reduced either by the carotid or by the aortic nerve section. The reduction observed following the carotid baroreceptor denervation accounted for the greater fraction of the overall reduction (74 versus 26%) in coefficient of variation for heart rate observed after @entity2 (4.8 +/- 0.9%, P less than 0.01). These data show that the carotid sinus and aortic nerves are similarly involved in control of blood pressure variability.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Differential control of blood pressure and heart rate by carotid and aortic baroreceptors in unanaesthetized XXXX .

answer: @entity1


abstract: We have examined whether there is a relationship between the lamellar-hexagonal phase transition temperature, TH, and the initial kinetics of H+- and @entity0 -induced destabilization of @entity2 (PE) liposomes. The liposomes were composed of @entity3 , egg @entity2 (EPE), or @entity2 prepared from egg @entity1 by transesterification (TPE). These lipids have well-spaced lamellar-hexagonal phase transition temperatures (approximately 12, approximately 45, and approximately 57 degrees C) in a temperature range that allows us to measure the initial kinetics of bilayer destabilization, both below and above TH. The liposomes were prepared at pH 9.5. The TH of EPE and TPE was measured by using differential scanning calorimetry, and it was found that the TH was essentially the same at low pH or at high pH in the presence of 20 mM @entity0 . At temperatures well below TH, either at pH 4.5 or at pH 9.5 in the presence of @entity0 , the liposomes aggregate, leak, and undergo lipid mixing and mixing of contents. We show that liposome/liposome contact is involved in the destabilization of the PE liposomes. The temperature dependence of leakage, lipid mixing, and mixing of contents shows that there is a massive enhancement in the rate of leakage when the temperature approaches the TH of the particular PE and that lipid mixing appears to be enhanced. However, the fusion (mixing of aqueous contents) is diminished or even abolished at temperatures above TH. At and above the TH, a new mechanism of liposome destabilization arises, evidently dependent upon the ability of the PE molecules to adapt new morphological structures at these temperatures. We propose that this destabilization demarks the first step in the pathway to the eventual formation of the HII phase. Thus, the polymorphism accessible to PE is a powerful agent for membrane destabilization, but additional factors are required for fusion.

title: Destabilization of XXXX liposomes at the hexagonal phase transition temperature.

answer: @entity2


abstract: OBJECTIVE: The purpose of this study was to investigate the possible benefit of the @entity4 based combined chemotherapy introduced as an "up front" chemotherapy in Hungary for the treatment of @entity1 . METHODS: Data of four Hungarian Ovary Cancer Treatment Center was collected, evaluated and presented here as a preliminary retrospective study. Data of 67 @entity0 was included into the investigation who underwent laparatomy followed with @entity4 / @entity5 or @entity4 / @entity3 combined chemotherapy between 1st of July 1999 and 31st of December 2000. The @entity4 was administered as 135 mg/m2 i.v. infusion for 3 hours. The main attention was pay on the response rate and the side effect occurred during the administration of the anticancer drugs. RESULTS: 34 out of 67 @entity0 underwent optimal surgery, and 33 out of 67 had got suboptimal procedure only. The chemotherapy was started at the 7th postoperative day. 430 cycles of chemotherapy was evaluated. The overall response rate (RR) at the end of the treatment was 76.1% (CR 68.65%. PR 7.46%). At the end of the follow-up there was 41 @entity0 free of disease (61.19%), 12 @entity0 alive with @entity2 (17.91%), 10 @entity0 (14.9%) died of disease, and there was 4 (6%) @entity0 lost. The overall survival (OS) during the follow up period was 16.82 months. In the suboptimally operated group, 36.3% of the @entity0 (12/33) underwent second laparotomy after the 3rd cycle of chemotherapy. Optimal operation was done in 8 out of this 12 @entity0 and all of optimally operated @entity0 remained free of disease at the and of the follow up. Three treatment out of 67 was interrupted because of major side effect, and 13 @entity0 needed supportive treatment. Eleven blood transfusions was performed during the chemotherapy and erythropoetin (EPO) was administered in two @entity0 . CONCLUSIONS: The outcome of @entity0 during of follow up period was better in the optimally operated group. There was 2 death compared to 8 in suboptimally operated group, the progression free survival (PFS) was longer (8 vs. 6.54 months), and so was the OS (17.11 vs. 16.54 months). More disease free @entity0 was registered at the end of follow-up in the optimally operated group (29 vs. 12). The haematological side effect was also more frequent in the suboptimally operated group (12 vs 1). The data suggest that the quality of initial surgical procedure remains the main prognostic factor even if @entity4 based combine chemotherapy is administered. On the other hand due to the @entity4 based chemotherapy seems to be a promising "up front" treatment in @entity0 with @entity1 with few major side effect generally, and quite a lot haematological side effect in the suboptimally operated group only.

title: [Experience in first-line chemotherapy with @entity4 for the treatment of XXXX ].

answer: @entity1


abstract: OBJECTIVE: The purpose of this study was to investigate the possible benefit of the @entity4 based combined chemotherapy introduced as an "up front" chemotherapy in Hungary for the treatment of @entity1 . METHODS: Data of four Hungarian Ovary Cancer Treatment Center was collected, evaluated and presented here as a preliminary retrospective study. Data of 67 @entity0 was included into the investigation who underwent laparatomy followed with @entity4 / @entity5 or @entity4 / @entity3 combined chemotherapy between 1st of July 1999 and 31st of December 2000. The @entity4 was administered as 135 mg/m2 i.v. infusion for 3 hours. The main attention was pay on the response rate and the side effect occurred during the administration of the anticancer drugs. RESULTS: 34 out of 67 @entity0 underwent optimal surgery, and 33 out of 67 had got suboptimal procedure only. The chemotherapy was started at the 7th postoperative day. 430 cycles of chemotherapy was evaluated. The overall response rate (RR) at the end of the treatment was 76.1% (CR 68.65%. PR 7.46%). At the end of the follow-up there was 41 @entity0 free of disease (61.19%), 12 @entity0 alive with @entity2 (17.91%), 10 @entity0 (14.9%) died of disease, and there was 4 (6%) @entity0 lost. The overall survival (OS) during the follow up period was 16.82 months. In the suboptimally operated group, 36.3% of the @entity0 (12/33) underwent second laparotomy after the 3rd cycle of chemotherapy. Optimal operation was done in 8 out of this 12 @entity0 and all of optimally operated @entity0 remained free of disease at the and of the follow up. Three treatment out of 67 was interrupted because of major side effect, and 13 @entity0 needed supportive treatment. Eleven blood transfusions was performed during the chemotherapy and erythropoetin (EPO) was administered in two @entity0 . CONCLUSIONS: The outcome of @entity0 during of follow up period was better in the optimally operated group. There was 2 death compared to 8 in suboptimally operated group, the progression free survival (PFS) was longer (8 vs. 6.54 months), and so was the OS (17.11 vs. 16.54 months). More disease free @entity0 was registered at the end of follow-up in the optimally operated group (29 vs. 12). The haematological side effect was also more frequent in the suboptimally operated group (12 vs 1). The data suggest that the quality of initial surgical procedure remains the main prognostic factor even if @entity4 based combine chemotherapy is administered. On the other hand due to the @entity4 based chemotherapy seems to be a promising "up front" treatment in @entity0 with @entity1 with few major side effect generally, and quite a lot haematological side effect in the suboptimally operated group only.

title: [Experience in first-line chemotherapy with XXXX for the treatment of @entity1 ].

answer: @entity4


abstract: The cell cycle of cultured @entity0 @entity1 cells were observed with a SEM using the synchronous culture method and the following results were obtained. In the M phase, the cells changed morphologically to become a minimum size and rounded in shape. Filopodia became thin and straight and reached their maximum length. Moreover, @entity2 reaches their greatest number. In the G0+1 phase, the cells developed from a round shape to an oval shape, and finally became polymorphic. The ends of the filopodia degenerated and became shortened. The number of @entity2 was decreased only in this stage. During the S phase, the cells became slender and reached maximum size. Short filopodia reappeared. No @entity2 but the largest microvilli were found. When we compared the late G1 with the early G2 phase, we found polymorphism of the cells and coexistence of microvilli and @entity2 common to both phases. However, ruffles were observed only in the former phase, while in the latter phase renewal of short filopodia together with thick and bent filopodia was evident. When we compared the late G2 with the early G1 phase, we found that the cells were small in size and round shape, and that the existence of @entity2 was common to both phases. However, the tips of the filopodia were destroyed in the latter phase, while in the former phase thick and bent filopodia were observed.

title: [Scanning electron microscopic studies on the cell surface and cell synchronized culture of @entity0 XXXX (HEC-1) cells].

answer: @entity1


abstract: The cell cycle of cultured @entity0 @entity1 cells were observed with a SEM using the synchronous culture method and the following results were obtained. In the M phase, the cells changed morphologically to become a minimum size and rounded in shape. Filopodia became thin and straight and reached their maximum length. Moreover, @entity2 reaches their greatest number. In the G0+1 phase, the cells developed from a round shape to an oval shape, and finally became polymorphic. The ends of the filopodia degenerated and became shortened. The number of @entity2 was decreased only in this stage. During the S phase, the cells became slender and reached maximum size. Short filopodia reappeared. No @entity2 but the largest microvilli were found. When we compared the late G1 with the early G2 phase, we found polymorphism of the cells and coexistence of microvilli and @entity2 common to both phases. However, ruffles were observed only in the former phase, while in the latter phase renewal of short filopodia together with thick and bent filopodia was evident. When we compared the late G2 with the early G1 phase, we found that the cells were small in size and round shape, and that the existence of @entity2 was common to both phases. However, the tips of the filopodia were destroyed in the latter phase, while in the former phase thick and bent filopodia were observed.

title: [Scanning electron microscopic studies on the cell surface and cell synchronized culture of XXXX @entity1 (HEC-1) cells].

answer: @entity0


abstract: Curves relating @entity0 and mean arterial pressure were derived in conscious @entity1 during ramp changes in mean arterial pressure, elicited by perivascular balloon inflation. The @entity0 -mean arterial pressure relationship consisted of a high-gain sigmoidal region about resting, where @entity0 rose or fell in response to moderate falls and rises of mean arterial pressure. With larger pressure rises, @entity0 first fell to a lower plateau and then reversed at even higher mean arterial pressure. When mean arterial pressure was lowered below resting, @entity0 rose to an upper plateau and then reversed abruptly toward resting at low mean arterial pressure. Both arterial and cardiac baroreceptors exerted substantial inhibitory influences on @entity0 at all pressure levels. These effects appeared additive over the central high gain region of the curve, but beyond this region there were non-additive interactions. The latter were affected considerably by alfathesin anesthesia. In other experiments, we studied the effects of sustained alterations in resting mean arterial pressure induced by infusing @entity2 and @entity3 , which produced rapid resetting of the renal baroreflex. The latter could be accounted for, in part, by resetting of the threshold of the arterial baroreceptors and in part by contributions from other afferents, probably the cardiac receptors. During resetting associated with @entity2 -induced falls in resting blood pressure, high-gain reflex adjustments in @entity0 to moderate changes in mean arterial pressure were preserved, but during resetting associated with @entity3 -induced rises in resting mean mean arterial pressure, the resting @entity0 lay on the lower curve plateau, resulting in reduction in the apparent gain of the reflex @entity0 response to moderate changes in mean arterial pressure.

title: The renal sympathetic baroreflex in the XXXX . Arterial and cardiac baroreceptor influences, resetting, and effect of anesthesia.

answer: @entity1


abstract: Forty-five @entity0 with @entity4 were treated with @entity5 ( @entity5 ) and @entity6 . @entity0 received @entity5 , 100 mg orally daily; @entity6 administration, 300 mg orally four times daily, was initiated on day 15 of therapy, and treatment with both drugs was continued until progression of disease. Three @entity0 are too early to evaluate (on study less than or equal to 2 months with no change in @entity1 status). Objective responses (greater than or equal to 50% reduction in measurable disease) occurred in 14 of 42 evaluable @entity0 (33.3%) (the 95% confidence interval based on this rate is +/- 14.3%), with three complete responses and 11 partial responses (PR). Complete responses lasted 9.5, 4+, and 9.5+ months. The median duration of response for the PR group was 5 months (range, 4 to 21+ months). Twelve @entity0 experienced stabilization of disease ranging from 4 to 16.5+ months. No response was seen in 16 @entity0 . There was no symptomatic, hematologic, or chemical (organ dysfunction) @entity2 among the 45 @entity0 treated. @entity5 and @entity6 appear to be safe and active agents in the treatment of metastatic @entity3 . Further studies are required to determine the optimal dose and scheduling of these agents.

title: Treatment of XXXX with @entity5 ( @entity5 ) and @entity6 : a pilot study.

answer: @entity4


abstract: Forty-five @entity0 with @entity4 were treated with @entity5 ( @entity5 ) and @entity6 . @entity0 received @entity5 , 100 mg orally daily; @entity6 administration, 300 mg orally four times daily, was initiated on day 15 of therapy, and treatment with both drugs was continued until progression of disease. Three @entity0 are too early to evaluate (on study less than or equal to 2 months with no change in @entity1 status). Objective responses (greater than or equal to 50% reduction in measurable disease) occurred in 14 of 42 evaluable @entity0 (33.3%) (the 95% confidence interval based on this rate is +/- 14.3%), with three complete responses and 11 partial responses (PR). Complete responses lasted 9.5, 4+, and 9.5+ months. The median duration of response for the PR group was 5 months (range, 4 to 21+ months). Twelve @entity0 experienced stabilization of disease ranging from 4 to 16.5+ months. No response was seen in 16 @entity0 . There was no symptomatic, hematologic, or chemical (organ dysfunction) @entity2 among the 45 @entity0 treated. @entity5 and @entity6 appear to be safe and active agents in the treatment of metastatic @entity3 . Further studies are required to determine the optimal dose and scheduling of these agents.

title: Treatment of @entity4 with XXXX ( @entity5 ) and @entity6 : a pilot study.

answer: @entity5