abstract: BACKGROUND: Catheter ablation of the slow atrioventricular (AV) pathway has been shown to be safe and effective in pediatric @entity0 with @entity1 ( @entity1 ). Despite that, acute success is not guaranteed, and safety of ablating near the AV node remains a concern. METHODS: A retrospective analysis was performed of all @entity1 ablations using the Ensite NavX voltage mapping technique at our institution. Each map was reviewed with @entity0 and NavX computer data recorded. To account for a learning curve, each map was idealized and compared with the original map. Procedure and fluoroscopy time were compared with a control group. RESULTS: Twenty-eight @entity0 underwent catheter ablation for @entity1 from September 2011 until December 2012 using the voltage mapping technique. The historical control group comprised 24 @entity0 who underwent catheter ablation using the electroanatomic approach. There was 96% acute success with one recurrence in the voltage mapping group, at a mean follow-up of 24 months. The slow pathway was visualized in 86% of @entity0 at the time of ablation, while three of four without could be found on idealization of the voltage map. Mean high- and low-voltage parameters increased with idealization, but showed no correlation with age, gender, or weight. Estimated pathway size had significant inter- @entity0 variability. Procedure and fluoroscopy times did not vary significantly compared with controls. CONCLUSION: Visualization of the AV nodal slow pathway in a pediatric population is possible using voltage mapping technique with the potential to increase safety and efficacy. Variability exists in the voltage parameters needed to visualize individual slow pathways, which leads to a distinct learning curve.

title: Visualization of XXXX Reentry Tachycardia Slow Pathways Using Voltage Mapping for Pediatric Catheter Ablation.

answer: @entity1


abstract: INTRODUCTION: @entity1 is characterized by white guttate macules with a typical histological structure: @entity2 with @entity3 . OBSERVATION: A 23-year-old @entity0 , from Algeria, presented with white macules from 5 years ago. Few @entity0 in her family had the same trouble. Cutaneous examination revealed diffused white little macules. Histological examination showed a @entity2 of the epidermis, with elongated club-shaped rete ridges and an unusual loss of pigmentation. DISCUSSION: Different diagnosis should be discussed with disseminated leucoderma macules. Nevertheless, the only one which corresponds with our case is the white @entity4 . To our knowledge, it is the first case described since Grosshans et al. in 1994. Our @entity0 is a descendant of the original case's family. This new case appears to confirm the genetic origin of the disorder and suggests autosomal dominant or X-linked inheritance.

title: [A second case of white XXXX .]

answer: @entity4


abstract: UNASSIGNED: Recent evidence suggests that @entity3 supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain. In a study primarily assessing the effects of various @entity3 supplements on blood @entity3 levels, we also investigated the effects of @entity3 supplements on blood pressure and their acute effects on @entity2 . We randomised 100 post-menopausal @entity0 to 1 g/d of @entity3 or a placebo containing no @entity3 . Blood pressure was measured at baseline and every 2 h up to 8 h after their first dose and after 3 months of supplementation. @entity2 was measured by thromboelastography (TEG) in a subgroup of @entity0 (n 40) up to 8 h only. Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The @entity1 was smaller in the @entity3 group compared with the control group by >5 mmHg between 2 and 6 h (P <=0  02), and the @entity1 was smaller at 2 h (between-groups difference 4  5 mmHg, P=0  004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the @entity4 and control groups. At 4 h, the increase in the coagulation index was greater in the @entity4 group compared with the control group (P=0  03), which appeared to be due to a greater reduction in the time to clot initiation. These data suggest that @entity3 supplements may acutely influence blood pressure and @entity2 . Further investigation of this possibility is required.

title: Acute effects of calcium supplements on blood pressure and XXXX : secondary analysis of a randomised controlled trial in post-menopausal @entity0 .

answer: @entity2


abstract: UNASSIGNED: Recent evidence suggests that @entity3 supplements increase the risk of cardiovascular events, but the mechanism(s) by which this occurs is uncertain. In a study primarily assessing the effects of various @entity3 supplements on blood @entity3 levels, we also investigated the effects of @entity3 supplements on blood pressure and their acute effects on @entity2 . We randomised 100 post-menopausal @entity0 to 1 g/d of @entity3 or a placebo containing no @entity3 . Blood pressure was measured at baseline and every 2 h up to 8 h after their first dose and after 3 months of supplementation. @entity2 was measured by thromboelastography (TEG) in a subgroup of @entity0 (n 40) up to 8 h only. Blood pressure declined over 8 h in both the groups, consistent with its normal diurnal rhythm. The @entity1 was smaller in the @entity3 group compared with the control group by >5 mmHg between 2 and 6 h (P <=0  02), and the @entity1 was smaller at 2 h (between-groups difference 4  5 mmHg, P=0  004). Blood coagulability, assessed by TEG, increased from baseline over 8 h in the @entity4 and control groups. At 4 h, the increase in the coagulation index was greater in the @entity4 group compared with the control group (P=0  03), which appeared to be due to a greater reduction in the time to clot initiation. These data suggest that @entity3 supplements may acutely influence blood pressure and @entity2 . Further investigation of this possibility is required.

title: Acute effects of calcium supplements on blood pressure and @entity2 : secondary analysis of a randomised controlled trial in post-menopausal XXXX .

answer: @entity0


abstract: OBJECTIVES: To assess the safety and efficacy of @entity9 -eluting stents (BES, BioMatrix    and BioMatrix Flex   ) in routine clinical practice. BACKGROUND: The LEADERS randomized trial has documented equivalent efficacy and superior safety of the BES when compared to a first generation @entity8 -eluting Cypher(TM) stent. METHODS: 5,472 @entity0 from 57 centers, treated with BES, were enrolled in an international multicenter registry and followed clinically up to 2 years. RESULTS: Mean @entity0 age was 63.2        11 years, 24% of @entity0 had @entity1 , and 49.8% presented with an @entity7 . 99.3% of @entity0 were discharged on dual antiplatelet therapy (DAPT), 83.3% remained on DAPT at 1 year and 30.6% at 2 years. The incidence of the composite primary end point [major adverse @entity3 (MACE) at 12 months] was 4.5% [ @entity2 0.9%, @entity5 1.7%, clinically indicated target vessel revascularization (ci-TVR) 2.8%]. MACE incidence was 6.8% at 24 months ( @entity2 .5%, @entity5 2.4%, ci-TVR 4.3%). At 12 months, 32 @entity0 (0.6%) had suffered at least one definite or probable stent @entity6 (ST), and 91 @entity0 (1.7%) a @entity4 ( @entity4 ). Nine @entity0 with ST (27.3%) and 7 @entity0 with a @entity4 (7.7%) died during the first year after the index procedure. Between 12 and 24 months after implantation, there were 18 (0.4%) additional @entity4 and 8 (0.2%) additional ST. CONCLUSIONS: This large international cohort documents a low 12 and 24 months MACE incidence and a very low ST incidence in an unselected @entity0 population undergoing BES implantation. The results are in keeping with those of the randomized controlled LEADERS trial. Even though ST with this stent was a rare event, it was still associated with significant mortality. @entity4 remains a problem, and warrants improved tailoring of DAPT in recipients of drug eluting stents.    2015 Wiley Periodicals, Inc.

title: Outcomes following implantation of the XXXX -eluting BioMatrix coronary stent: Primary analysis of the e-BioMatrix registry.

answer: @entity9


abstract: BACKGROUND AIMS: With the increasing use of cell therapies involving immune modulatory cells, there is a need for a simple standardized method to evaluate and compare the suppressive potency of different cell products. We used the @entity0 (K299) cell line as the reference suppressor cell to develop a standardized suppression assay to quantify the immune-modulatory capacity of bone marrow-derived mesenchymal stromal cells (BM-MSCs). METHODS: Healthy donor @entity2 T cells were co-cultured with the K299 cell line or with third-party BM-MSCs. After stimulation with anti-CD3/ @entity3 beads, @entity4 activation and proliferation of @entity2 T cells were measured to calculate suppression. RESULTS: The K299 cell line reproducibly suppressed both the activation and proliferation of healthy donor @entity2 T cells in a dose-dependent manner. A rapid (16-h) assay that was based on activation-suppression was selected for development. In replicate testing, there was an inherent variability of suppression of 11% coefficient of variation between different responder T cells. Suppression by BM-MSCs on different responders correlated with suppression by K299. We therefore used K299 suppression as the reference to define suppression potency of BM-MSCs in K299 Suppression Units. We found that inter-donor variability, passage number, method of manufacture and exposure of BM-MSCs to @entity1 or interferon-y all affected BM-MSC potency of suppression. CONCLUSIONS: This method provides a platform for standardizing suppressor function to facilitate comparisons between laboratories and for use as a cell product release assay.

title: Quantitative activation suppression assay to evaluate XXXX bone marrow-derived mesenchymal stromal cell potency.

answer: @entity0


abstract: BACKGROUND: The SYNTAX score is an angiographic score which predicts @entity1 . It has been shown to be useful for decision making about percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) among @entity0 with @entity1 . Higher SYNTAX scores are indicative of more complex disease. @entity2 ( @entity2 ) is characterized by limitation of airflow. Meassurement of forced expiratory volume in 1 second (FEV1) in spirometry is used for diagnosis and determining the severity of the disease. AIM: The aim of this study was to evaluate the relationship between forced expiratory volume in 1 s (FEV1) and SYNTAX score in @entity0 wtih @entity2 ( @entity2 ). METHODS: Seventy eight @entity0 with a previous diagnosis of @entity2 and 48 @entity0 without @entity2 were enrolled. Spirometry and coronary angiography were performed in all @entity0 . SYNTAX score was calculated and compared between two groups. The correlation between FEV1 and SYNTAX score was analyzed. RESULTS: SYNTAX score was higher in @entity0 with @entity2 than @entity0 without @entity2 (23.22  12.10 vs 17.92  11.21 respectively, p=0.013). Multivariate analysis demonstrated that @entity2 was an independently predictive for intermediate and high SYNTAX score (odds ratio 4.833; 95% confidence interval 2.228-10.485; p<0.001). Mean FEV1 (% predicted) was 64.7  11.4 and negatively correlated with SYNTAX score in @entity2 group ( r= -0.266 and p=0.018). The receiver operating characteristic analysis yielded a cutoff value of 65.5 for the FEV1 to predict SYNTAX score >=  23, with sensivity and specifity being 78.6% and 70%, respectively. CONCLUSIONS: @entity2 is a predictor of higher SYNTAX scores. FEV1 is associated with more severe and @entity1 .

title: FEV1 can predict SYNTAX score in XXXX with chronic obtructive pulmonary disease.

answer: @entity0


abstract: UNASSIGNED: @entity11 ( @entity11 ) is a major cause of chronic @entity3 worldwide. @entity12 ( @entity13 ) is a drug that has anti-inflammatory properties due to its effects on the metabolism of @entity9 . Thus, the present study examined the anti-inflammatory effects of @entity13 on the mechanisms of @entity11 . C57BL/6 @entity0 were divided into seven groups: 1) control, 2) @entity13 50 mg/kg, 3) @entity2 , 4) @entity2 + @entity13 50 mg/kg, 5) @entity2 + @entity15 50mg/kg 6) @entity2 + @entity16 ( @entity18 ) 100 mg/kg and 7) @entity2 + @entity18 100 mg/kg + @entity13 50mg/kg. Liver fragments were stained with HE and Sirius red, and processed for immunofluorescence, western blot and immunohistochemistry. Furthermore, serum was collected for biochemical measurements. @entity2 induced @entity3 , elevation in collagen content and increased expression of NF-kB and inflammatory markers ( @entity7 , IFN-y, @entity6 , @entity17 , @entity14 and @entity8 ). Treatment with @entity13 was able to reduce @entity3 and the collagen content, the NF-kB and inflammatory markers expression, ameliorated biochemistry parameters (total @entity1 , HDL @entity1 , @entity4 content and @entity5 aminotransferase) and increased the expression of anti-inflammatory markers (p-AMPK and @entity10 ). Future clinical trials may demonstrate that oral administration of @entity13 may be suitable for the treatment of @entity11 as other @entity3 . This article is protected by copyright. All rights reserved.

title: XXXX : possible therapeutic alternative in the treatment of @entity11 in C57BL/6 @entity0 .

answer: @entity12


abstract: UNASSIGNED: @entity11 ( @entity11 ) is a major cause of chronic @entity3 worldwide. @entity12 ( @entity13 ) is a drug that has anti-inflammatory properties due to its effects on the metabolism of @entity9 . Thus, the present study examined the anti-inflammatory effects of @entity13 on the mechanisms of @entity11 . C57BL/6 @entity0 were divided into seven groups: 1) control, 2) @entity13 50 mg/kg, 3) @entity2 , 4) @entity2 + @entity13 50 mg/kg, 5) @entity2 + @entity15 50mg/kg 6) @entity2 + @entity16 ( @entity18 ) 100 mg/kg and 7) @entity2 + @entity18 100 mg/kg + @entity13 50mg/kg. Liver fragments were stained with HE and Sirius red, and processed for immunofluorescence, western blot and immunohistochemistry. Furthermore, serum was collected for biochemical measurements. @entity2 induced @entity3 , elevation in collagen content and increased expression of NF-kB and inflammatory markers ( @entity7 , IFN-y, @entity6 , @entity17 , @entity14 and @entity8 ). Treatment with @entity13 was able to reduce @entity3 and the collagen content, the NF-kB and inflammatory markers expression, ameliorated biochemistry parameters (total @entity1 , HDL @entity1 , @entity4 content and @entity5 aminotransferase) and increased the expression of anti-inflammatory markers (p-AMPK and @entity10 ). Future clinical trials may demonstrate that oral administration of @entity13 may be suitable for the treatment of @entity11 as other @entity3 . This article is protected by copyright. All rights reserved.

title: @entity12 : possible therapeutic alternative in the treatment of XXXX in C57BL/6 @entity0 .

answer: @entity11


abstract: UNASSIGNED: @entity11 ( @entity11 ) is a major cause of chronic @entity3 worldwide. @entity12 ( @entity13 ) is a drug that has anti-inflammatory properties due to its effects on the metabolism of @entity9 . Thus, the present study examined the anti-inflammatory effects of @entity13 on the mechanisms of @entity11 . C57BL/6 @entity0 were divided into seven groups: 1) control, 2) @entity13 50 mg/kg, 3) @entity2 , 4) @entity2 + @entity13 50 mg/kg, 5) @entity2 + @entity15 50mg/kg 6) @entity2 + @entity16 ( @entity18 ) 100 mg/kg and 7) @entity2 + @entity18 100 mg/kg + @entity13 50mg/kg. Liver fragments were stained with HE and Sirius red, and processed for immunofluorescence, western blot and immunohistochemistry. Furthermore, serum was collected for biochemical measurements. @entity2 induced @entity3 , elevation in collagen content and increased expression of NF-kB and inflammatory markers ( @entity7 , IFN-y, @entity6 , @entity17 , @entity14 and @entity8 ). Treatment with @entity13 was able to reduce @entity3 and the collagen content, the NF-kB and inflammatory markers expression, ameliorated biochemistry parameters (total @entity1 , HDL @entity1 , @entity4 content and @entity5 aminotransferase) and increased the expression of anti-inflammatory markers (p-AMPK and @entity10 ). Future clinical trials may demonstrate that oral administration of @entity13 may be suitable for the treatment of @entity11 as other @entity3 . This article is protected by copyright. All rights reserved.

title: @entity12 : possible therapeutic alternative in the treatment of @entity11 in C57BL/6 XXXX .

answer: @entity0


abstract: UNASSIGNED: The midbrain ventrolateral periaqueductal gray (VL-PAG) is a key component that mediates @entity3 modulation. Although spinal cord glial cells appear to play an important role in @entity4 development, the precise mechanisms involving descending facilitation pathways from the PAG following @entity2 are poorly understood. This study shows that cellular events that occur during glial activation in the VL-PAG may promote descending facilitation from the PAG during @entity0 . @entity6 ( @entity6 ) was induced by ligature construction of the sciatic nerve in male @entity1 . Behavioral responses to noxious mechanical (paw withdrawal threshold; PWT) and thermal (paw withdrawal latency; PWL) stimuli were evaluated. After @entity6 , immunohistochemical and Western blot analysis of microglia and astrocytes in the VL-PAG showed morphological and quantitative changes indicative of activation in microglia and astrocytes. Intra-VL-PAG injection of microglial or astrocytic inhibitors attenuated PWT and PWL at days 7 and 14, respectively, following @entity6 . We also evaluated the effects of intra-VL-PAG administration of the phosphorylated @entity7 (p- @entity7 MAPK) inhibitor @entity5 at day 7 after @entity6 . This treatment abolished microglial activation and produced a significant time-dependent attenuation of PWT and PWL. Western blot analysis showed localized expression of p- @entity7 in the VL-PAG after @entity6 . P- @entity7 was expressed in labeled microglia of the VL-PAG but was not present in astrocytes and neurons on day 7 after @entity6 . These results demonstrate that @entity6 -induced @entity0 is associated with glial activation in the VL-PAG, which likely participates in descending @entity3 facilitation through the @entity7 MAPK signaling pathway.    2015 Wiley Periodicals, Inc.

title: Glial activation in the periaqueductal gray promotes descending facilitation of XXXX through the @entity7 MAPK signaling pathway.

answer: @entity0


abstract: UNASSIGNED: The midbrain ventrolateral periaqueductal gray (VL-PAG) is a key component that mediates @entity3 modulation. Although spinal cord glial cells appear to play an important role in @entity4 development, the precise mechanisms involving descending facilitation pathways from the PAG following @entity2 are poorly understood. This study shows that cellular events that occur during glial activation in the VL-PAG may promote descending facilitation from the PAG during @entity0 . @entity6 ( @entity6 ) was induced by ligature construction of the sciatic nerve in male @entity1 . Behavioral responses to noxious mechanical (paw withdrawal threshold; PWT) and thermal (paw withdrawal latency; PWL) stimuli were evaluated. After @entity6 , immunohistochemical and Western blot analysis of microglia and astrocytes in the VL-PAG showed morphological and quantitative changes indicative of activation in microglia and astrocytes. Intra-VL-PAG injection of microglial or astrocytic inhibitors attenuated PWT and PWL at days 7 and 14, respectively, following @entity6 . We also evaluated the effects of intra-VL-PAG administration of the phosphorylated @entity7 (p- @entity7 MAPK) inhibitor @entity5 at day 7 after @entity6 . This treatment abolished microglial activation and produced a significant time-dependent attenuation of PWT and PWL. Western blot analysis showed localized expression of p- @entity7 in the VL-PAG after @entity6 . P- @entity7 was expressed in labeled microglia of the VL-PAG but was not present in astrocytes and neurons on day 7 after @entity6 . These results demonstrate that @entity6 -induced @entity0 is associated with glial activation in the VL-PAG, which likely participates in descending @entity3 facilitation through the @entity7 MAPK signaling pathway.    2015 Wiley Periodicals, Inc.

title: Glial activation in the periaqueductal gray promotes descending facilitation of @entity0 through the XXXX MAPK signaling pathway.

answer: @entity7


abstract: PURPOSE: We sought to develop a reproducible @entity5 injection technique to induce urethral @entity2 in the @entity1 urethra. MATERIALS AND METHODS: A total of 32 male @entity1 weighing 300 to 350 gm were anesthetized with @entity6 / @entity7 intraperitoneally. Using a 5 mm penoscrotal incision the @entity1 urethra was exposed. In the experimental group varying doses of @entity5 (5, 10 and 25  g) were injected in each side of the urethral wall. Normal saline infiltration was used in the sham treated group. @entity1 were sacrificed 2 and 4 weeks following @entity5 injection. Urethral specimens were stained with @entity3 and @entity4 , and Masson trichrome, and Western blot evaluations were performed. Normal and strictured urethral tissues from @entity0 were collected and evaluated in the same fashion. RESULTS: There was no evidence of urethral wall thickening or @entity2 in the sham treated group. Varied histological evidence of @entity2 was noted in all experimental groups. There was a significant increase in collagen type I expression 2 weeks after injection of 5, 10 and 25  g @entity5 . Collagen type III expression was significantly increased 2 weeks after injecting 10 and 25  g of @entity5 , which persisted to 28 days after injection. CONCLUSIONS: @entity5 injection can successfully generate a reproducible @entity1 model of urethral spongiofibrosis. This technique is simple, inexpensive and reproducible. Our series is a proof of concept study. Additional studies in larger animals are needed to further confirm our findings.

title: Transforming Growth Factor-b1 Induced Urethral XXXX in a @entity1 Model.

answer: @entity2


abstract: PURPOSE: We sought to develop a reproducible @entity5 injection technique to induce urethral @entity2 in the @entity1 urethra. MATERIALS AND METHODS: A total of 32 male @entity1 weighing 300 to 350 gm were anesthetized with @entity6 / @entity7 intraperitoneally. Using a 5 mm penoscrotal incision the @entity1 urethra was exposed. In the experimental group varying doses of @entity5 (5, 10 and 25  g) were injected in each side of the urethral wall. Normal saline infiltration was used in the sham treated group. @entity1 were sacrificed 2 and 4 weeks following @entity5 injection. Urethral specimens were stained with @entity3 and @entity4 , and Masson trichrome, and Western blot evaluations were performed. Normal and strictured urethral tissues from @entity0 were collected and evaluated in the same fashion. RESULTS: There was no evidence of urethral wall thickening or @entity2 in the sham treated group. Varied histological evidence of @entity2 was noted in all experimental groups. There was a significant increase in collagen type I expression 2 weeks after injection of 5, 10 and 25  g @entity5 . Collagen type III expression was significantly increased 2 weeks after injecting 10 and 25  g of @entity5 , which persisted to 28 days after injection. CONCLUSIONS: @entity5 injection can successfully generate a reproducible @entity1 model of urethral spongiofibrosis. This technique is simple, inexpensive and reproducible. Our series is a proof of concept study. Additional studies in larger animals are needed to further confirm our findings.

title: Transforming Growth Factor-b1 Induced Urethral @entity2 in a XXXX Model.

answer: @entity1


abstract: BACKGROUND: Embolism from unstable @entity7 in the carotid bifurcation is a major cause of @entity2 . Here, we analysed gene expression in endarterectomies from @entity0 with symptomatic (S) and @entity11 ( @entity11 ) @entity4 to identify pathways linked to plaque instability. METHODS: Microarrays were prepared from plaques (n = 127) and peripheral blood samples (n = 96) of S and @entity11 @entity0 . Gene set enrichment, pathway mapping and network analyses of differentially expressed genes were performed. RESULTS: These studies revealed upregulation of haemoglobin metabolism (P = 2.20E-05) and bone resorption (P = 9.63E-04) in S @entity0 . Analysis of subgroups of @entity0 indicated enrichment of @entity5 and osteoblast differentiation in S @entity0 on statins, as well as @entity1 and apoptosis in plaques removed >1 month compared to <2 weeks after symptom. By prediction profiling, a panel of 30 genes, mostly transcription factors, discriminated between plaques from S versus @entity11 @entity0 with 78% accuracy. By meta-analysis, common gene networks associated with @entity6 mapped to @entity3 , chemokines, @entity5 , actin cytoskeleton and extracellular matrix. A set of dysregulated genes ( @entity12 , @entity13 , @entity14 and @entity9 ) previously not described in @entity6 were identified from microarrays and validated by quantitative PCR and immunohistochemistry. CONCLUSIONS: Our findings confirmed a central role for @entity1 and proteases in plaque instability, and highlighted haemoglobin metabolism and bone resorption as important pathways. Subgroup analysis suggested prolonged @entity1 following the symptoms of plaque instability and @entity5 as a possible stabilizing mechanism by @entity10 . In addition, transcriptional regulation may play an important role in the determination of plaque phenotype. The results from this study will serve as a basis for further exploration of molecular signatures in @entity8 .

title: Gene expression signatures, pathways and networks in XXXX .

answer: @entity8


abstract: PURPOSE AND METHODS: We investigated the relationship between fear of @entity1 recurrence (FCR), @entity2 , supportive care needs, and utilization of health-care services in a mixed sample of 335 @entity1 @entity0 . We used validated questionnaires including the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the General @entity2 Scale (GAD-7) and the Supportive Care Needs Survey (SCNS-SF34). Health-care services utilization was measured by a self-constructed questionnaire recording the use of 22 health and supportive care offers. RESULTS: In our sample, 3.9  % of @entity0 were classified as having high @entity2 and 5.1  % had high FCR. @entity0 reported the highest unmet supportive care needs in the domain health system and information followed by @entity3 . Integrated care and complementary support services were the most frequently used (32  %) followed by medical (31  %), psychological (23  %), spiritual and religious (8  %) and other support services (9  %). Whereas @entity2 was related to both unmet psychological and physical/daily living needs (p   <   0.01), FCR was associated  with unmet supportive care needs in all five domains further including needs with regard to health system and information, @entity0 care, and sexuality (p   <   0.01). However, higher levels of @entity2 and FCR were not related to higher utilization of health-care services. CONCLUSION: Our findings show that FCR plays a significant role in unmet supportive care needs in @entity1 @entity0 but not for health-care service utilization. IMPLICATIONS FOR CANCER SURVIVORS: We recommend that clinicians monitor supportive care needs in @entity0 struggling with FCR and @entity2 .

title: XXXX recurrence and its association with supportive care needs and health-care service utilization in @entity1 @entity0 .

answer: @entity1


abstract: PURPOSE AND METHODS: We investigated the relationship between fear of @entity1 recurrence (FCR), @entity2 , supportive care needs, and utilization of health-care services in a mixed sample of 335 @entity1 @entity0 . We used validated questionnaires including the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the General @entity2 Scale (GAD-7) and the Supportive Care Needs Survey (SCNS-SF34). Health-care services utilization was measured by a self-constructed questionnaire recording the use of 22 health and supportive care offers. RESULTS: In our sample, 3.9  % of @entity0 were classified as having high @entity2 and 5.1  % had high FCR. @entity0 reported the highest unmet supportive care needs in the domain health system and information followed by @entity3 . Integrated care and complementary support services were the most frequently used (32  %) followed by medical (31  %), psychological (23  %), spiritual and religious (8  %) and other support services (9  %). Whereas @entity2 was related to both unmet psychological and physical/daily living needs (p   <   0.01), FCR was associated  with unmet supportive care needs in all five domains further including needs with regard to health system and information, @entity0 care, and sexuality (p   <   0.01). However, higher levels of @entity2 and FCR were not related to higher utilization of health-care services. CONCLUSION: Our findings show that FCR plays a significant role in unmet supportive care needs in @entity1 @entity0 but not for health-care service utilization. IMPLICATIONS FOR CANCER SURVIVORS: We recommend that clinicians monitor supportive care needs in @entity0 struggling with FCR and @entity2 .

title: @entity1 recurrence and its association with supportive care needs and health-care service utilization in XXXX @entity0 .

answer: @entity1


abstract: PURPOSE AND METHODS: We investigated the relationship between fear of @entity1 recurrence (FCR), @entity2 , supportive care needs, and utilization of health-care services in a mixed sample of 335 @entity1 @entity0 . We used validated questionnaires including the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the General @entity2 Scale (GAD-7) and the Supportive Care Needs Survey (SCNS-SF34). Health-care services utilization was measured by a self-constructed questionnaire recording the use of 22 health and supportive care offers. RESULTS: In our sample, 3.9  % of @entity0 were classified as having high @entity2 and 5.1  % had high FCR. @entity0 reported the highest unmet supportive care needs in the domain health system and information followed by @entity3 . Integrated care and complementary support services were the most frequently used (32  %) followed by medical (31  %), psychological (23  %), spiritual and religious (8  %) and other support services (9  %). Whereas @entity2 was related to both unmet psychological and physical/daily living needs (p   <   0.01), FCR was associated  with unmet supportive care needs in all five domains further including needs with regard to health system and information, @entity0 care, and sexuality (p   <   0.01). However, higher levels of @entity2 and FCR were not related to higher utilization of health-care services. CONCLUSION: Our findings show that FCR plays a significant role in unmet supportive care needs in @entity1 @entity0 but not for health-care service utilization. IMPLICATIONS FOR CANCER SURVIVORS: We recommend that clinicians monitor supportive care needs in @entity0 struggling with FCR and @entity2 .

title: @entity1 recurrence and its association with supportive care needs and health-care service utilization in @entity1 XXXX .

answer: @entity0


abstract: In a prospective study of @entity0 in the first trimester who were at risk for recurrent abortion, data from 20 pregnancies with normal outcomes were contrasted with those of 9 pregnancies that aborted spontaneously between 7 and 12 weeks. In pregnancies in which an embryo was present before abortion, the mean concentrations of @entity0 @entity6 ( @entity6 ) were low with a steady decline in @entity2 levels, whereas @entity1 (E2) and @entity4 concentrations approximated those in normal pregnancies. With growth disorganization, mean @entity6 , E2, and @entity2 levels were significantly lower than normal. In 87.5% of @entity3 , conclusive evidence of this disorder was obtained with ultrasound monitoring. Subnormal levels of @entity6 , E2, and @entity2 were observed in 88.9, 100, and 57.1%, respectively. The karyotype was abnormal in 80% of @entity3 successfully cultured. The normal production of E2 appeared dependent on the presence of the embryo in the first trimester of pregnancy. Endocrine failure of the trophoblast and/or the corpus luteum in embryopathic pregnancy is suggested by diminished @entity6 and @entity2 concentrations. Serial ultrasound scanning and hormone assay, particularly of @entity6 and E2, may be useful in assessing pregnancy at risk for recurrent abortion. However, because subnormal hormone levels may occur relatively late in the clinical course of @entity5 , ultrasound scanning may yield more useful results as compared with hormone assay. Further studies are required to define more clearly the mechanisms of endocrine failure in embryopathic pregnancy.

title: @entity0 chorionic gonadotropin, @entity1 , @entity2 , XXXX , and B-scan ultrasound monitoring of complications in early pregnancy.

answer: @entity4


abstract: In a prospective study of @entity0 in the first trimester who were at risk for recurrent abortion, data from 20 pregnancies with normal outcomes were contrasted with those of 9 pregnancies that aborted spontaneously between 7 and 12 weeks. In pregnancies in which an embryo was present before abortion, the mean concentrations of @entity0 @entity6 ( @entity6 ) were low with a steady decline in @entity2 levels, whereas @entity1 (E2) and @entity4 concentrations approximated those in normal pregnancies. With growth disorganization, mean @entity6 , E2, and @entity2 levels were significantly lower than normal. In 87.5% of @entity3 , conclusive evidence of this disorder was obtained with ultrasound monitoring. Subnormal levels of @entity6 , E2, and @entity2 were observed in 88.9, 100, and 57.1%, respectively. The karyotype was abnormal in 80% of @entity3 successfully cultured. The normal production of E2 appeared dependent on the presence of the embryo in the first trimester of pregnancy. Endocrine failure of the trophoblast and/or the corpus luteum in embryopathic pregnancy is suggested by diminished @entity6 and @entity2 concentrations. Serial ultrasound scanning and hormone assay, particularly of @entity6 and E2, may be useful in assessing pregnancy at risk for recurrent abortion. However, because subnormal hormone levels may occur relatively late in the clinical course of @entity5 , ultrasound scanning may yield more useful results as compared with hormone assay. Further studies are required to define more clearly the mechanisms of endocrine failure in embryopathic pregnancy.

title: @entity0 chorionic gonadotropin, XXXX , @entity2 , @entity4 , and B-scan ultrasound monitoring of complications in early pregnancy.

answer: @entity1


abstract: In a prospective study of @entity0 in the first trimester who were at risk for recurrent abortion, data from 20 pregnancies with normal outcomes were contrasted with those of 9 pregnancies that aborted spontaneously between 7 and 12 weeks. In pregnancies in which an embryo was present before abortion, the mean concentrations of @entity0 @entity6 ( @entity6 ) were low with a steady decline in @entity2 levels, whereas @entity1 (E2) and @entity4 concentrations approximated those in normal pregnancies. With growth disorganization, mean @entity6 , E2, and @entity2 levels were significantly lower than normal. In 87.5% of @entity3 , conclusive evidence of this disorder was obtained with ultrasound monitoring. Subnormal levels of @entity6 , E2, and @entity2 were observed in 88.9, 100, and 57.1%, respectively. The karyotype was abnormal in 80% of @entity3 successfully cultured. The normal production of E2 appeared dependent on the presence of the embryo in the first trimester of pregnancy. Endocrine failure of the trophoblast and/or the corpus luteum in embryopathic pregnancy is suggested by diminished @entity6 and @entity2 concentrations. Serial ultrasound scanning and hormone assay, particularly of @entity6 and E2, may be useful in assessing pregnancy at risk for recurrent abortion. However, because subnormal hormone levels may occur relatively late in the clinical course of @entity5 , ultrasound scanning may yield more useful results as compared with hormone assay. Further studies are required to define more clearly the mechanisms of endocrine failure in embryopathic pregnancy.

title: @entity0 chorionic gonadotropin, @entity1 , XXXX , @entity4 , and B-scan ultrasound monitoring of complications in early pregnancy.

answer: @entity2


abstract: In a prospective study of @entity0 in the first trimester who were at risk for recurrent abortion, data from 20 pregnancies with normal outcomes were contrasted with those of 9 pregnancies that aborted spontaneously between 7 and 12 weeks. In pregnancies in which an embryo was present before abortion, the mean concentrations of @entity0 @entity6 ( @entity6 ) were low with a steady decline in @entity2 levels, whereas @entity1 (E2) and @entity4 concentrations approximated those in normal pregnancies. With growth disorganization, mean @entity6 , E2, and @entity2 levels were significantly lower than normal. In 87.5% of @entity3 , conclusive evidence of this disorder was obtained with ultrasound monitoring. Subnormal levels of @entity6 , E2, and @entity2 were observed in 88.9, 100, and 57.1%, respectively. The karyotype was abnormal in 80% of @entity3 successfully cultured. The normal production of E2 appeared dependent on the presence of the embryo in the first trimester of pregnancy. Endocrine failure of the trophoblast and/or the corpus luteum in embryopathic pregnancy is suggested by diminished @entity6 and @entity2 concentrations. Serial ultrasound scanning and hormone assay, particularly of @entity6 and E2, may be useful in assessing pregnancy at risk for recurrent abortion. However, because subnormal hormone levels may occur relatively late in the clinical course of @entity5 , ultrasound scanning may yield more useful results as compared with hormone assay. Further studies are required to define more clearly the mechanisms of endocrine failure in embryopathic pregnancy.

title: XXXX chorionic gonadotropin, @entity1 , @entity2 , @entity4 , and B-scan ultrasound monitoring of complications in early pregnancy.

answer: @entity0


abstract: OBJECTIVES: To evaluate longer-term safety and efficacy of a single self-expanding stent up to 20 cm in length in @entity0 with @entity3 of the superficial femoral (SFA) and proximal popliteal arteries. BACKGROUND: Angioplasty and stenting are options for revascularization of symptomatic @entity4 . While angioplasty alone is effective in short lesions, outcomes in longer lesions (i.e., mean 8.7 cm) show suboptimal patency rates of 33% at one year. METHODS: Two hundred eighty-seven @entity0 (mean age 68 years, 66% male) were treated with the EverFlex    Self-Expanding Peripheral Stent System. @entity0 were followed through 3 years with yearly core lab adjudicated duplex ultrasonography for patency, radiographic assessment of stent @entity2 , and resting ankle brachial indices. RESULTS: Overall freedom from loss of primary patency at 3 years was 60.0%. Patency was significantly higher for lesions  <=8 cm compared with lesions >8 cm (71.0 vs. 50.5%, P   <   0.0001). There was no significant difference in patency between single-stent and multistent recipients (60.4 vs. 52.4%, P   =   0.343). The three-year freedom from clinically driven @entity1 revascularization was 70.0%. At 3 years, the overall stent @entity2 rate was 0.9%. CONCLUSIONS: DURABILITY II is the first investigational device exemption trial to report 3-year duplex Doppler defined stent patency and CD-TLR outcomes in long SFA and proximal popliteal lesions and demonstrated acceptable stent patency and freedom from CD-TLR with a low @entity2 rate. These data suggest that use of a single long stent provides reasonable long-term outcomes when intervention is required for symptomatic SFA and proximal popliteal arterial disease.    2015 Wiley Periodicals, Inc.

title: A single stent strategy in XXXX with lifestyle limiting claudication: 3-year results from the Durability II trial.

answer: @entity0


abstract: OBJECTIVE: To describe the clinical, laboratory, and histopathologic features of idiopathic @entity11 in @entity0 . STUDY DESIGN: Retrospective review of all liver biopsies performed at Boston @entity0 's Hospital, Massachusetts General Hospital, and the University of Massachusetts Medical Center from 1991 to 1994. Chart review was performed when biopsies demonstrated @entity11 . RESULTS: Eighty-two @entity0 had biopsy-proven @entity11 . Fourteen @entity0 had @entity11 without evidence of inherited, infectious, @entity9 . All 14 @entity0 were @entity1 , averaging 159% of ideal body weight (range, 121% to 222%). Nine @entity0 initially had transient @entity6 , two had @entity5 , and one was identified by incidental laboratory evaluation. These 12 @entity0 had biopsies because of persistent elevations of aminotransferase levels. Two other @entity0 without risk factors for @entity11 were identified at staging laparotomy for @entity10 . The 10 @entity0 and 4 @entity0 had an average age of 13.5 years (range, 10 to 18 years). Aminotransferase elevations were modest, with @entity7 aminotransferase and @entity8 aminotransferase values averaging 77 +/- 38 IU and 129 +/- 73 IU, respectively. All had imaging studies demonstrating @entity11 . Histologic examination of biopsy specimens revealed varying degrees of @entity11 with @entity2 and @entity3 . CONCLUSION: Idiopathic @entity11 occurs predominantly or exclusively in @entity1 peripubertal @entity0 . This entity represents a frequent reason for liver biopsy in this age group. The degree of @entity11 , @entity3 , and @entity2 does not correlate with symptoms or signs, and significant @entity4 with bridging @entity3 may be present.

title: Idiopathic XXXX in childhood: a multicenter retrospective study.

answer: @entity11


abstract: BACKGROUND AND AIM: @entity6 ( @entity6 ) primary or secondary represents approximately 16-32% of @entity6 cases. Most @entity0 present with mild, chronic @entity7 with exacerbation of the condition in the cold environment. Red cell transfusions are only indicated when there is a life-threatening @entity2 causing crisis. We studied the clinical and serological characterization of @entity6 with the aim that the information gained from this study would help in proper diagnosis and management of these @entity0 . MATERIALS AND METHODS: The prospective study included nine @entity0 who were admitted with severe @entity2 . Detailed work-up were conducted to establish the diagnosis, severity of in vivo @entity5 and transfusion management. RESULTS: All @entity0 presented with pallor, @entity3 , @entity1 with exacerbation of symptoms in winter months. Secondary @entity6 was observed in three @entity0 suffering from @entity4 . Red cells of all @entity0 were coated with complements (C3) more specifically @entity8 . In one @entity0 suffering from @entity4 , the cold autoagglutinin titer was as high as 4096. Autoantibody in seven @entity0 was specific to "I" antigen and one to "i" antigen. CONCLUSIONS: We conclude that detailed clinical and serological characterization is needed to diagnose and manage @entity6 . Whereas avoidance of cold exposure is the primary therapy, but no critical @entity0 should be denied blood transfusion due to serological complications. All transfusion services should follow the correct protocol to maximize blood safety in @entity6 .

title: Clinical and serological characterization of XXXX in a Tertiary Care Hospital in Eastern India.

answer: @entity6


abstract: BACKGROUND: Few studies have examined the mode of birth among @entity0 with @entity1 , and the results are conflicting. The objective of this study was to assess the association between @entity1 and cesarean delivery in North European @entity0 . METHODS: A longitudinal cohort study was conducted among 6,422 pregnant @entity0 from Belgium, Iceland, Denmark, Estonia, Norway, and Sweden. @entity1 was measured by the Wijma Delivery Expectancy Questionnaire during pregnancy and linked to obstetric information from hospital records. RESULTS: Among 3,189 primiparous @entity0 , those reporting severe @entity1 were more likely to give birth by elective cesarean, (OR, 1.66 [95% CI 1.05-2.61]). Among 3,233 multiparous @entity0 , severe @entity1 increased the risk of elective cesarean (OR 1.87 [95% CI 1.30-2.69]). Reporting lack of positive anticipation, one of six dimensions of @entity1 , was most strongly associated with elective cesarean (OR 2.02 [95% CI 1.52-2.68]). A dose-effect pattern was observed between level of fear and risk of emergency cesarean in both primiparous and multiparous @entity0 . Indications for cesarean were more likely to be reported as "nonmedical" among those with severe @entity1 ; 16.7 versus 4.6 percent in primiparous @entity0 , and 31.7 versus 17.5 percent in multiparous @entity0 . CONCLUSION: Having severe @entity1 increases the risk of elective cesarean, especially among multiparous @entity0 . Lack of positive anticipation of the upcoming childbirth seems to be an important dimension of fear associated with cesarean delivery. Counseling for @entity0 who do not look forward to vaginal birth should be further evaluated.

title: XXXX and risk of cesarean delivery: a cohort study in six European countries.

answer: @entity1


abstract: AIM: To investigate the relationship between contrast-enhanced ultrasound (CEUS), @entity4 ( @entity4 ), @entity5 ( @entity5 ), and @entity3 ( @entity3 ) recurrence after ablation. METHODS: A total of 51 @entity3 @entity0 (38 males and 13 females) who received radiofrequency ablation in our hospital from June 2012 to July 2014 were enrolled in this study. The @entity0 were divided into two groups: recurrence group and non-recurrence group. Routine abdominal examination was first performed in the horizontal position. Then the @entity0 underwent CEUS and immunohistochemical staining before receiving radiofrequency ablation. All @entity0 were followed-up every three months for one year. The results of CEUS and serum @entity2 marker levels were evaluated and combined together to estimate @entity3 recurrence and @entity1 . @entity0 were divided into two groups: recurrence group and non-recurrence group. Quantitative parameters of CEUS and @entity2 expression levels of @entity4 and @entity5 were compared between the two groups, respectively. Binary logistic regression analysis was used to analyze the relationship between CEUS quantitative parameters, expression levels of @entity5 and @entity4 , and @entity3 recurrence after ablation. RESULTS: Based on the quantitative parameters of CEUS before @entity0 received radiofrequency ablation, the levels of @entity2 rise time (tRT), @entity2 time to peak (tTTP), @entity2 peak intensity (tPI) and @entity2 -parenchymal peak intensity (t-pPI) in the recurrence group were significantly lower than those in the non-recurrence group (16.6    6.1 vs 23.2    7.0, P = 0.000; 41.2    10.2 vs 59.6    14.2, P = 0.000; 23.8    6.7 vs 31.4    6.4, P = 0.000; 7.1    3.4 vs 14.6    7.4, P = 0.000; respectively). The expression levels of @entity4 in the recurrence group were significantly higher than those in the non-recurrence group (P < 0.05). Levels of tTTP showed a significant inverse correlation with the level of @entity4 in @entity2 (r = -0.312, P = 0.037). The Binary logistic regression analysis results revealed that the levels of tRT, tTTP, tPI and the level of @entity4 were associated with @entity3 recurrence after radiofrequency ablation (P < 0.05). CONCLUSION: CEUS is a noninvasive and effective method for evaluating the angiogenesis of @entity3 , and predicting its recurrence and prognosis.

title: Predictive value of quantitative contrast-enhanced ultrasound in XXXX recurrence after ablation.

answer: @entity3


abstract: @entity5 ( @entity5 ) is a serious condition affecting predominantly the premature @entity0 . The purpose of this study is to report a multicenter experience of complications in 252 @entity0 requiring surgical therapy for @entity5 . Data from eight institutions for the years 1980 through 1990 were collected and analyzed for @entity0 undergoing surgical therapy for @entity5 . Records were reviewed for gestational age, birth weight, age at operation, indications for operation, degree of intestinal involvement, operation(s) performed, complications, and 30-day mortality rates. A total of 264 @entity0 underwent surgical intervention for @entity5 during the study period. Complete information was available for 252 @entity0 . The mean gestational age was 31 +/- 5 weeks and the mean birth weight was 1,552 +/- 823 g. The mean age at operation was 18 +/- 35 days. @entity3 was the most common indication for operation (42%). The 30-day survival rate was 72%. Eighty-one percent of @entity0 underwent primary laparotomy, whereas peritoneal drainage was performed in 48 (19%) @entity0 . @entity1 were identified in 119 (47%) @entity0 . The most common @entity1 were @entity2 (9%), intestinal strictures (9%), and short gut (9%). @entity4 occurred in 6%, and the incidence of intraabdominal abscess formation was only 2.3%. Gestational age < 27 weeks (P < .005) and birth weight < 1,000 g (P < .005) were associated with significantly increased mortality but no increase in postoperative morbidity. The incidence of complications was similar in the very low birth weight (< 1,000 g) @entity0 (51%) compared with @entity0 > or = 1,000 g (46%).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Complications after surgical intervention for XXXX : a multicenter review.

answer: @entity5


abstract: Locomotor sensitization, the augmentation of the locomotor-activating effects of stimuli with repeated exposure, is being evaluated as a partial model for several phenomena including @entity2 . Alteration of dopaminergic systems has been found in sensitized animals and @entity3 neurotransmission appears to be crucial for the expression of sensitized behaviors. However, stress hormones, which are released after exposure to many of the stimuli that produce sensitization, may also be involved in the development of this phenomenon. @entity5 appears to be important in the development of @entity7 sensitization and glucocorticoid receptors (GR) have been hypothesized to mediate this effect. The purpose of these experiments was first, to determine whether repeated restraint stress sensitizes DBA/2J @entity0 to the activating effect of @entity4 ( @entity1 ), and second, to explore the role of GR in stress- and @entity1 -induced sensitization with the GR antagonist, @entity6 . This antagonist was administered before restraint or i.p. @entity1 (1.5 g/kg) on each of 10 consecutive days of pretreatment. In addition, plasma @entity5 levels were determined at various points throughout the pretreatment period and on test days. The results demonstrated that 10 consecutive days of 2-hr restraint sensitized @entity0 to @entity1 's locomotor-stimulating effect. Both stress- and @entity1 -induced sensitization were attenuated by administration of @entity6 during the pretreatment phase.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Critical role for glucocorticoid receptors in stress- and XXXX -induced locomotor sensitization.

answer: @entity4


abstract: BACKGROUND: @entity4 ) @entity1 indicates favorable prognosis in @entity2 (SCC). The purpose of this study was for us to assess the impact of HPV in @entity0 treated with sequential therapy versus concomitant chemoradiotherapy (CRT). METHODS: @entity0 with stage III and IVA and B oropharyngeal SCC were reviewed spanning 10 years. RESULTS: Among 500 cases, 291 (58%) received CRT versus 209 (42%) sequential therapy. HPV status was known in 279 of @entity0 (56%) and positive in 77% (determined by polymerase chain reaction [PCR; 91%], @entity3 immunohistochemical [IHC], or both). Median follow-up was 2.8 years. Overall survival (OS) did not differ for sequential therapy versus CRT overall (hazard ratio [HR]   =   0.90; p   =   .66; 3-year OS   =   86% and 87%) or within HPV-positive @entity0 (HR   =   0.89; p   =   .81; 3-year OS   =   91% and 91%) or within HPV-negative @entity0 (HR   =   0.55; p = .32; 3-year OS   =   85% and 75%). CONCLUSION: Survival for all @entity0 was high and notable for HPV-negative @entity0 treated with sequential therapy. Further studies in this @entity0 population are warranted.    2015 Wiley Periodicals, Inc. Head Neck 38: E1618-E1624, 2016.

title: XXXX and induction chemotherapy versus concurrent chemoradiotherapy in locally advanced oropharyngeal cancer: The Dana Farber Experience.

answer: @entity4


abstract: BACKGROUND: Even among @entity0 considered to be functionally eligible for major lung resection, some experience postoperative @entity3 . Based on our previous study with quantitative computed tomography (CT), we hypothesized that postoperative @entity3 is associated with the collapse of the remaining lung, and thus, prediction of the postoperative lung volume may contribute to risk assessment for postoperative @entity3 . METHODS: We measured the @entity2 and functional lung volume (FLV) separately on whole lung CT using an image analysis software in 290 @entity0 undergoing major lung resection for cancer between January 2006 and December 2012. The postoperative FLV was predicted by a stepwise multiple regression analysis. RESULTS: Fourteen @entity0 @entity1 (complicated group), five of them presented with @entity4 . The postoperatively measured FLV was significantly lower in the complicated group than in the control group (P  <  0.01). The postoperative FLV could be calculated using preoperative variables, including the forced vital capacity, number of resected segments, FLV, and @entity2 . The predicted postoperative FLV was significantly lower in the complicated group than in the control group (P  <  0.01, area under the curve  =  0.78; sensitivity 86%; specificity 73%). The predicted postoperative FLV was also useful in distinguishing complicated @entity0 from matched-control @entity0 who had similar preoperative pulmonary function (P  =  0.02). CONCLUSIONS: @entity1 is likely accompanied by a collapse of the remaining lung. Quantitative assessment of the lung morphology on preoperative CT is useful to screen for @entity0 at risk of postoperative @entity3 .

title: XXXX and @entity4 .

answer: @entity1


abstract: BACKGROUND: Even among @entity0 considered to be functionally eligible for major lung resection, some experience postoperative @entity3 . Based on our previous study with quantitative computed tomography (CT), we hypothesized that postoperative @entity3 is associated with the collapse of the remaining lung, and thus, prediction of the postoperative lung volume may contribute to risk assessment for postoperative @entity3 . METHODS: We measured the @entity2 and functional lung volume (FLV) separately on whole lung CT using an image analysis software in 290 @entity0 undergoing major lung resection for cancer between January 2006 and December 2012. The postoperative FLV was predicted by a stepwise multiple regression analysis. RESULTS: Fourteen @entity0 @entity1 (complicated group), five of them presented with @entity4 . The postoperatively measured FLV was significantly lower in the complicated group than in the control group (P  <  0.01). The postoperative FLV could be calculated using preoperative variables, including the forced vital capacity, number of resected segments, FLV, and @entity2 . The predicted postoperative FLV was significantly lower in the complicated group than in the control group (P  <  0.01, area under the curve  =  0.78; sensitivity 86%; specificity 73%). The predicted postoperative FLV was also useful in distinguishing complicated @entity0 from matched-control @entity0 who had similar preoperative pulmonary function (P  =  0.02). CONCLUSIONS: @entity1 is likely accompanied by a collapse of the remaining lung. Quantitative assessment of the lung morphology on preoperative CT is useful to screen for @entity0 at risk of postoperative @entity3 .

title: @entity1 and XXXX .

answer: @entity4


abstract: 1. We studied the effect of servo-controlled stretch of smooth muscle strips from @entity0 uterus on tension and intracellular @entity1 concentration ([ @entity1 ]i, using @entity3 as an indicator) at 30 degrees C. 2. When quiescent uterine muscle strips were stretched at a ramp time of 0.5 s by multiples of 5% of the resting muscle length (L0) up to 40%, forty-two out of sixty muscle strips responded with a transient active contraction and a [ @entity1 ]i increase. The minimum excursion of stretch required for contraction was 26.3 +/- 7.5% of L0 (mean +/- S.D.). The peak response had an all-or-none property and was almost independent of the duration of stretch. 3. Stretches of 30 or 35% of L0 induced contraction in most cases when rapidly applied in 0.2-0.5 s, but slowly applied stretch (ramp duration of 5-10 s) rarely induced contraction. 4. The stretch-induced response was inhibited by the removal of extracellular @entity1 or by the addition of 10 nM @entity4 . However, it was unaffected by 1 microM tetrodotoxin, 1 microM @entity5 or by 10 microM @entity6 , an inhibitor of @entity1 -ATPase in intracellular @entity1 stores. 5. When a stretch of 15-35% of L0 was applied during the relaxation phase of 10 nM @entity2 -induced rhythmic contractions, the first contraction after the stretch occurred earlier than that expected from the control rhythm. However, the frequency of the subsequent rhythm returned to almost the control level even during continued application of stretch, although the half-width of rhythmic contractions was increased during stretch. 6. The present study demonstrates that stretch of uterine muscle induces a transient contraction due to @entity1 influx, which is myogenic and dependent on the excursion and velocity of stretch. The all-or-none property of the stretch-induced contractions suggests initiation of @entity1 spikes. Furthermore, stretch modulates the @entity2 -induced rhythmic contractions.

title: Stretch-induced enhancement of contractions in uterine smooth muscle of XXXX .

answer: @entity0


abstract: OBJECTIVE: To investigate whether being anesthesia administered at least once in early life influenced 3 main proxies of visual function: visual acuity, @entity4 , and optic nerve health in young adulthood. STUDY DESIGN: At age 20  years, @entity0 of the Western Australian Pregnancy Cohort Study had comprehensive ocular examinations including visual acuity, postcycloplegic refraction, and multiple scans of the optic disc. We identified individuals who had at least 1 procedure requiring anesthesia during the first 3  years of life (between 1990 and 1994) and compared their visual outcomes with nonexposed individuals. We excluded 40 @entity0 with strabismus or other @entity1 or surgery and 136 with non-European background. RESULTS: Of 834 @entity0 , 15.2% (n  =  127) were exposed to anesthesia at least once before age 3  years. In both exposed and nonexposed groups, median visual acuity (measured using the logarithm of the minimum angle of resolution [LogMAR] chart) was -0.06 LogMAR in the right eye and -0.08 LogMAR in the left eye (P  >  .05). Median spherical equivalent @entity4 was +0.44 diopters (IQR -0.25, +0.63) and +0.31 diopters (IQR -0.38, +0.63) in the exposed and nonexposed group, respectively (P  =  .126). No difference was detected in mean global retinal nerve fiber layer thickness of the 2 groups (100.7 vs 100.1   m, P  =  .830). CONCLUSIONS: We were unable to demonstrate an association of exposure to anesthesia as a @entity0 with reduced visual acuity or increased @entity3 or thinning of retinal nerve fiber layer. These findings support the view that anesthesia is unlikely to impair visual development, but further work is needed to establish whether more @entity2 are present and repeated exposures have any effects.

title: Early Anesthesia Exposure and the Effect on Visual Acuity, XXXX , and Retinal Nerve Fiber Layer Thickness of Young Adults.

answer: @entity4


abstract: UNASSIGNED: @entity1 management is an unresolved problem. Biomaterials to limit unwanted axonal growth could be a tool to manage @entity1 . Hyaluronic acid/ @entity2 cellulose (HA/CMC) is an antiadhesive, biodegradable material that is nontoxic to nerve. The purpose of this study was to evaluate the efficacy of this biomaterial to limit axonal growth. @entity0 received a sciatic nerve transection and repair with a short conduit (5 mm) containing HA/CMC, fibrin, or nothing (empty conduit). In another study, nerve was transected and either left undisturbed or wrapped with HA/CMC around the proximal and distal ends. In a final study, nerve was transected and repaired with an HA/CMC wrap. Four weeks following the procedures, nerves were harvested and assessed using histomorphometry to measure axonal regeneration. Axonal regeneration following transection was significantly inhibited by direct axonal contact with HA/CMC, whether within a conduit or wrapped around the transected proximal nerve end. Axonal regeneration following epineurial repair was not affected by HA/CMC wrapped around nerve, demonstrating axonal growth inhibition due to direct contact of regenerating axons with HA/CMC. These studies demonstrate the efficacy of HA/CMC to limit axonal outgrowth by contact with regenerating axons. HA/CMC barriers may prove to be a tool to prevent @entity1 formation by inhibiting axonal growth.    2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.

title: Hyaluronic acid/ XXXX cellulose directly applied to transected nerve decreases axonal outgrowth.

answer: @entity2


abstract: PURPOSE: @entity2 ( @entity2 ) is one of the most common @entity1 worldwide with an unchanged 5-year survival rate during the last decade. To detect reliable prognostic markers and improve @entity0 ' outcome in future, the aim of our study was to detect differences in microRNA (miRNA; @entity3 ) expression profile and further on to analyze the functional role of selected miRNAs. METHODS: Blood samples from @entity2 @entity0 and sex- and age-matched healthy volunteers were analyzed by microarrays and validated by quantitative real-time PCR. Data were compared with @entity1 tissue results and all findings were correlated with clinical parameters. Additionally, the proliferation and migration potential of two cell lines transfected with miRNA mimics and inhibitors for @entity4 and @entity5 were examined. RESULTS: Initial analysis of blood samples showed no significant differences between the miRNA profile of @entity2 @entity0 and healthy controls (p  >  0.05). Interestingly, down-regulation of @entity4 and @entity5 in blood of @entity0 correlated with the occurrence of distant metastasis regarding @entity1 @entity0 only (p  =  0.023 and p  =  0.028, respectively). Additionally, our investigations in tissue samples revealed a lower expression of @entity5 in @entity1 cells (p  =  0.003) and a correlation with higher cT-classification for down-regulation of @entity4 (p  =  0.005). Moreover, functional assays demonstrated that inhibition of @entity4 and @entity5 promoted dramatically proliferation and migration potential, whereas transfection of both mimics had an inhibitory effect. CONCLUSIONS: Characterizing the expression of @entity4 and @entity5 and their functional role in @entity1 biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in @entity2 .

title: Characterization of @entity4 and XXXX in blood, tissue and cell lines of @entity2 @entity0 and their impact on cell proliferation and migration.

answer: @entity5


abstract: PURPOSE: @entity2 ( @entity2 ) is one of the most common @entity1 worldwide with an unchanged 5-year survival rate during the last decade. To detect reliable prognostic markers and improve @entity0 ' outcome in future, the aim of our study was to detect differences in microRNA (miRNA; @entity3 ) expression profile and further on to analyze the functional role of selected miRNAs. METHODS: Blood samples from @entity2 @entity0 and sex- and age-matched healthy volunteers were analyzed by microarrays and validated by quantitative real-time PCR. Data were compared with @entity1 tissue results and all findings were correlated with clinical parameters. Additionally, the proliferation and migration potential of two cell lines transfected with miRNA mimics and inhibitors for @entity4 and @entity5 were examined. RESULTS: Initial analysis of blood samples showed no significant differences between the miRNA profile of @entity2 @entity0 and healthy controls (p  >  0.05). Interestingly, down-regulation of @entity4 and @entity5 in blood of @entity0 correlated with the occurrence of distant metastasis regarding @entity1 @entity0 only (p  =  0.023 and p  =  0.028, respectively). Additionally, our investigations in tissue samples revealed a lower expression of @entity5 in @entity1 cells (p  =  0.003) and a correlation with higher cT-classification for down-regulation of @entity4 (p  =  0.005). Moreover, functional assays demonstrated that inhibition of @entity4 and @entity5 promoted dramatically proliferation and migration potential, whereas transfection of both mimics had an inhibitory effect. CONCLUSIONS: Characterizing the expression of @entity4 and @entity5 and their functional role in @entity1 biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in @entity2 .

title: Characterization of XXXX and @entity5 in blood, tissue and cell lines of @entity2 @entity0 and their impact on cell proliferation and migration.

answer: @entity4


abstract: PURPOSE: @entity2 ( @entity2 ) is one of the most common @entity1 worldwide with an unchanged 5-year survival rate during the last decade. To detect reliable prognostic markers and improve @entity0 ' outcome in future, the aim of our study was to detect differences in microRNA (miRNA; @entity3 ) expression profile and further on to analyze the functional role of selected miRNAs. METHODS: Blood samples from @entity2 @entity0 and sex- and age-matched healthy volunteers were analyzed by microarrays and validated by quantitative real-time PCR. Data were compared with @entity1 tissue results and all findings were correlated with clinical parameters. Additionally, the proliferation and migration potential of two cell lines transfected with miRNA mimics and inhibitors for @entity4 and @entity5 were examined. RESULTS: Initial analysis of blood samples showed no significant differences between the miRNA profile of @entity2 @entity0 and healthy controls (p  >  0.05). Interestingly, down-regulation of @entity4 and @entity5 in blood of @entity0 correlated with the occurrence of distant metastasis regarding @entity1 @entity0 only (p  =  0.023 and p  =  0.028, respectively). Additionally, our investigations in tissue samples revealed a lower expression of @entity5 in @entity1 cells (p  =  0.003) and a correlation with higher cT-classification for down-regulation of @entity4 (p  =  0.005). Moreover, functional assays demonstrated that inhibition of @entity4 and @entity5 promoted dramatically proliferation and migration potential, whereas transfection of both mimics had an inhibitory effect. CONCLUSIONS: Characterizing the expression of @entity4 and @entity5 and their functional role in @entity1 biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in @entity2 .

title: Characterization of @entity4 and @entity5 in blood, tissue and cell lines of XXXX @entity0 and their impact on cell proliferation and migration.

answer: @entity2


abstract: PURPOSE: @entity2 ( @entity2 ) is one of the most common @entity1 worldwide with an unchanged 5-year survival rate during the last decade. To detect reliable prognostic markers and improve @entity0 ' outcome in future, the aim of our study was to detect differences in microRNA (miRNA; @entity3 ) expression profile and further on to analyze the functional role of selected miRNAs. METHODS: Blood samples from @entity2 @entity0 and sex- and age-matched healthy volunteers were analyzed by microarrays and validated by quantitative real-time PCR. Data were compared with @entity1 tissue results and all findings were correlated with clinical parameters. Additionally, the proliferation and migration potential of two cell lines transfected with miRNA mimics and inhibitors for @entity4 and @entity5 were examined. RESULTS: Initial analysis of blood samples showed no significant differences between the miRNA profile of @entity2 @entity0 and healthy controls (p  >  0.05). Interestingly, down-regulation of @entity4 and @entity5 in blood of @entity0 correlated with the occurrence of distant metastasis regarding @entity1 @entity0 only (p  =  0.023 and p  =  0.028, respectively). Additionally, our investigations in tissue samples revealed a lower expression of @entity5 in @entity1 cells (p  =  0.003) and a correlation with higher cT-classification for down-regulation of @entity4 (p  =  0.005). Moreover, functional assays demonstrated that inhibition of @entity4 and @entity5 promoted dramatically proliferation and migration potential, whereas transfection of both mimics had an inhibitory effect. CONCLUSIONS: Characterizing the expression of @entity4 and @entity5 and their functional role in @entity1 biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in @entity2 .

title: Characterization of @entity4 and @entity5 in blood, tissue and cell lines of @entity2 XXXX and their impact on cell proliferation and migration.

answer: @entity0


abstract: PURPOSE: To investigate the relationship between intra-prostatic levels of @entity6 oxygenase (HO), metaflammation in @entity4 ( @entity4 ) tissue in @entity0 with @entity3 and moderate-severe lower urinary tract symptoms (LUTS). METHODS: Between January 2012 and June 2013, 132 consecutive @entity0 , who underwent transurethral resection of the prostate for moderate-severe LUTS, secondary to clinical @entity4 , were enrolled. Prostate samples were investigated for the presence of an inflammatory infiltrate, according to the Irani score, and for @entity8 and @entity9 levels measurements. @entity0 were evaluated for the presence of @entity3 ( @entity3 ) defined by the International @entity1 Federation. RESULTS: We observed that subjects with @entity3 exhibited greater Irani score (3.0 vs. 2.0; p  <  0.05), Irani grade (2.0 vs. 1.0; p  <  0.05) and lower value of @entity8 (4.55 vs. 6.01; p  <  0.05) and @entity9 (0.81 vs. 2.66; p  <  0.05). @entity8 (3.91 vs. 5.67; p  <  0.05) and @entity9 (1.06 vs. 1.37; p  <  0.05) were significantly reduced in @entity0 with @entity5 (Irani score  >= 4). At the multivariate logistic regression analysis, @entity8 reduction (OR 0.588; p  <  0.01), waist circumference (OR 1.09; p  <  0.01), @entity7 (OR 1.013; p  <  0.05) and HDL (OR 0.750; p  <  0.05) were independent predictors of @entity5 . We also found that @entity8 reduction (OR 0.598; p  <  0.01) and the presence of @entity3 (OR 34.846; p  <  0.01) were associated with Irani score  >= 4. CONCLUSION: @entity3 -induced @entity2 may play a key role in @entity4 . In detail, prostate metaflammation is inversely related to intra-prostatic @entity8 levels, serum HDL and positively with @entity7 .

title: Heme oxygenase levels and metaflammation in XXXX @entity0 .

answer: @entity4


abstract: PURPOSE: To investigate the relationship between intra-prostatic levels of @entity6 oxygenase (HO), metaflammation in @entity4 ( @entity4 ) tissue in @entity0 with @entity3 and moderate-severe lower urinary tract symptoms (LUTS). METHODS: Between January 2012 and June 2013, 132 consecutive @entity0 , who underwent transurethral resection of the prostate for moderate-severe LUTS, secondary to clinical @entity4 , were enrolled. Prostate samples were investigated for the presence of an inflammatory infiltrate, according to the Irani score, and for @entity8 and @entity9 levels measurements. @entity0 were evaluated for the presence of @entity3 ( @entity3 ) defined by the International @entity1 Federation. RESULTS: We observed that subjects with @entity3 exhibited greater Irani score (3.0 vs. 2.0; p  <  0.05), Irani grade (2.0 vs. 1.0; p  <  0.05) and lower value of @entity8 (4.55 vs. 6.01; p  <  0.05) and @entity9 (0.81 vs. 2.66; p  <  0.05). @entity8 (3.91 vs. 5.67; p  <  0.05) and @entity9 (1.06 vs. 1.37; p  <  0.05) were significantly reduced in @entity0 with @entity5 (Irani score  >= 4). At the multivariate logistic regression analysis, @entity8 reduction (OR 0.588; p  <  0.01), waist circumference (OR 1.09; p  <  0.01), @entity7 (OR 1.013; p  <  0.05) and HDL (OR 0.750; p  <  0.05) were independent predictors of @entity5 . We also found that @entity8 reduction (OR 0.598; p  <  0.01) and the presence of @entity3 (OR 34.846; p  <  0.01) were associated with Irani score  >= 4. CONCLUSION: @entity3 -induced @entity2 may play a key role in @entity4 . In detail, prostate metaflammation is inversely related to intra-prostatic @entity8 levels, serum HDL and positively with @entity7 .

title: Heme oxygenase levels and metaflammation in @entity4 XXXX .

answer: @entity0


abstract: UNASSIGNED: Primary @entity5 of the breast is a rare variant, accounting for only 2% to 5% of diagnosed @entity0 , and may have relatively aggressive behavior. Mutational profiling of invasive @entity0 has yielded potential targets for directed @entity1 therapy, yet most studies have not included @entity5 . In a tissue microarray screen, we found a 2.4% prevalence (9/372) of neuroendocrine @entity0 , including several with lobular morphology. We then screened primary or metastatic @entity0 (excluding papillary and mucinous) for mutations in common @entity1 genes using polymerase chain reaction-mass spectroscopy (643 hotspot mutations across 53 genes), or semiconductor-based next-generation sequencing analysis (37 genes). Mutations were identified in 5 of 15 @entity1 , including 3 with @entity9 exon 9 @entity11 mutations, 2 of which also harbored point mutations in FGFR family members ( @entity7 @entity13 , @entity10 @entity14 ). Single mutations were found in each of @entity2 ( @entity15 ) and @entity8 ( @entity12 ). @entity9 mutations are common in other types of @entity0 . However, FGFR and RAS family mutations are exceedingly rare in the @entity0 literature. Likewise, activating mutations in the receptor @entity3 kinase @entity2 ( @entity2 ) have been reported in @entity6 and @entity4 ; the @entity2 @entity15 mutation is reported to be sensitive to @entity2 kinase inhibitors, and fibroblast growth factor receptor inhibitors are in trials. Our findings demonstrate the utility of broad-based genotyping in the study of rare @entity1 such as @entity0 .

title: Novel Mutations in XXXX of the Breast: Possible Therapeutic Targets.

answer: @entity5


abstract: OBJECTIVE: Treatment of malignant @entity2 (MPM) remains very challenging. Assessment of response to treatment is necessary for modifying treatment and using new drugs. Global disease assessment (GDA) by implementing image processing methods to extract more information out of positron emission tomography (PET) images may provide reliable information. In this study we show the feasibility of this method of semi-quantification in @entity0 with @entity2 , and compare it with the conventional methods. We also present a review of the literature about this topic. METHODS: Nineteen subjects with histologically proven MPM who had undergone fluoride-18-fluorodeoxyglucose PET/computed tomography ((18)F-FDG PET/CT) before and after treatment were included in this study. An adaptive contrast-oriented thresholding algorithm was used for the image analysis and semi-quantification. @entity1 volume (MTV), maximum and mean standardized uptake volume (SUVmax, SUVmean) and total lesion glycolysis (TLG) were calculated for each region of interest. The global @entity1 glycolysis (GTG) was obtained by summing up all TLG. Treatment response was assessed by the European Organisation for Research and Treatment of @entity1 (EORTC) criteria and the changes of GTG. Agreement between global disease assessment and conventional method was also determined. RESULTS: In @entity0 with progressive disease based on EORTC criteria, GTG showed an increase of 150.7 but in @entity0 with stable or partial response, GTG showed a decrease of 433.1. The SUVmax of @entity0 before treatment was 5.95 (SD: 2.93) and after the treatment it increased to 6.38 (SD: 3.19). Overall concordance of conventional method with GDA method was 57%. Concordance of progression of disease based on conventional method was 44%, stable disease was 85% and partial response was 33%. Discordance was 55%, 14% and 66%. CONCLUSIONS: Adaptive contrast-oriented thresholding algorithm is a promising method to quantify the whole @entity1 glycolysis in @entity0 with @entity2 . We are able to assess the total metabolic lesion volume, lesion glycolysis, SUVmax, @entity1 SUVmean and GTG for this particular @entity1 . Also we were able to demonstrate the potential use of this technique in the monitoring of treatment response. More studies comparing this technique with conventional and other global disease assessment methods are needed in order to clarify its role in the assessment of treatment response and prognosis of these @entity0 .

title: Feasibility and performance of an adaptive contrast-oriented FDG PET/CT quantification technique for global disease assessment of malignant XXXX and a brief review of the literature.

answer: @entity2


abstract: OBJECTIVE:: Management of @entity2 without persistent ST-segment elevation (NSTE-ACS) and @entity3 ( @entity3 ) remains challenging. The study aimed to analyze the current management of @entity3 @entity0 in German @entity1 units focussing on the different time lines of invasive strategy. METHODS:: A total of 1400 @entity3 @entity0 admitted to a certified @entity1 unit were enrolled. Analyses of high-risk criteria with indication for invasive management and of 3-month clinical outcomes were performed by subgrouping @entity3 @entity0 to immediate and early invasive (<8 hours), early elective invasive (8-24 hours), late elective invasive (24-72 hours) strategy, and without percutaneous coronary intervention (PCI). RESULTS:: Coronary angiography was performed in 60.6% of the @entity3 @entity0 , whereas PCI was necessary in 37%. Only 1.4% of the @entity3 @entity0 obtained immediate PCI within the first 120 minutes. In 16.9%, @entity0 received PCI within the first day of hospitalization or even within the first 8 hours after admission in another 7.7%, although the Global Registry of Acute Coronary Events (GRACE) score at admission was below 140. In the remaining 12.4% of the @entity3 @entity0 , PCI was performed within 24-72 hours after admission. Those @entity0 exhibited a higher prevalence of secondary risk markers than those with conservative treatment regimen. CONCLUSIONS:: To date, almost two-third of @entity3 @entity0 at intermediate to high risk receive rapid invasive regimen within the first 24 hours after admission. Oncoming studies will have to analyze its overall guideline-adherence and resulting differences in major adverse events.

title: Timing of Percutaneous Coronary Intervention in Troponin-negative @entity0 With XXXX Without Persistent ST-segment Elevation: Preliminary Results and Status Quo in German Chest Pain Units.

answer: @entity2


abstract: OBJECTIVE:: Management of @entity2 without persistent ST-segment elevation (NSTE-ACS) and @entity3 ( @entity3 ) remains challenging. The study aimed to analyze the current management of @entity3 @entity0 in German @entity1 units focussing on the different time lines of invasive strategy. METHODS:: A total of 1400 @entity3 @entity0 admitted to a certified @entity1 unit were enrolled. Analyses of high-risk criteria with indication for invasive management and of 3-month clinical outcomes were performed by subgrouping @entity3 @entity0 to immediate and early invasive (<8 hours), early elective invasive (8-24 hours), late elective invasive (24-72 hours) strategy, and without percutaneous coronary intervention (PCI). RESULTS:: Coronary angiography was performed in 60.6% of the @entity3 @entity0 , whereas PCI was necessary in 37%. Only 1.4% of the @entity3 @entity0 obtained immediate PCI within the first 120 minutes. In 16.9%, @entity0 received PCI within the first day of hospitalization or even within the first 8 hours after admission in another 7.7%, although the Global Registry of Acute Coronary Events (GRACE) score at admission was below 140. In the remaining 12.4% of the @entity3 @entity0 , PCI was performed within 24-72 hours after admission. Those @entity0 exhibited a higher prevalence of secondary risk markers than those with conservative treatment regimen. CONCLUSIONS:: To date, almost two-third of @entity3 @entity0 at intermediate to high risk receive rapid invasive regimen within the first 24 hours after admission. Oncoming studies will have to analyze its overall guideline-adherence and resulting differences in major adverse events.

title: Timing of Percutaneous Coronary Intervention in Troponin-negative XXXX With @entity2 Without Persistent ST-segment Elevation: Preliminary Results and Status Quo in German Chest Pain Units.

answer: @entity0


abstract: OBJECT The Milan Complexity Scale-a new practical grading scale designed to estimate the risk of neurological clinical worsening after performing surgery for @entity1 removal-is presented. METHODS A retrospective study was conducted on all elective consecutive surgical procedures for @entity1 resection between January 2012 and December 2014 at the Second Division of Neurosurgery at Fondazione IRCCS Istituto Neurologico Carlo Besta of Milan. A prospective database dedicated to reporting complications and all clinical and radiological data was retrospectively reviewed. The Karnofsky Performance Scale (KPS) was used to classify each @entity0 's health status. Complications were divided into major and minor and recorded based on etiology and required treatment. A logistic regression model was used to identify possible predictors of clinical worsening after surgery in terms of changes between the preoperative and discharge KPS scores. Statistically significant predictors were rated based on their odds ratios in order to build an ad hoc complexity scale. For each @entity0 , a corresponding total score was calculated, and ANOVA was performed to compare the mean total scores between the improved/unchanged and worsened @entity0 . Relative risk (RR) and chi-square statistics were employed to provide the risk of worsening after surgery for each total score. RESULTS The case series was composed of 746 @entity0 (53.2% female; mean age 51.3    17.1). The most common @entity1 were @entity5 (28.6%) and @entity3 (24.1%). The mortality rate was 0.94%, the major complication rate was 9.1%, and the minor complication rate was 32.6%. Of 746 @entity0 , 523 (70.1%) @entity0 improved or remained unchanged, and 223 (29.9%) @entity0 worsened. The following factors were found to be statistically significant predictors of the change in KPS scores: @entity1 size larger than 4 cm, @entity2 , major brain vessel manipulation, posterior fossa location, and eloquent area involvement (Nagelkerke R(2) = 0.286). A grading scale was obtained with scores ranging between 0 and 8. Worsened @entity0 showed mean total scores that were significantly higher than the improved/unchanged scores (3.24    1.55 vs 1.47    1.58; p < 0.001). Finally, a grid was developed to show the risk of worsening after surgery for each total score: scores higher than 3 are suggestive of worse clinical outcome. CONCLUSIONS Through the evaluation of the 5 aforementioned parameters-the Big Five-the Milan Complexity Scale enables neurosurgeons to estimate the risk of a negative clinical course after @entity4 surgery and share these data with the @entity0 . Furthermore, the Milan Complexity Scale could be used for research and educational purposes and better health system management.

title: Predicting functional impairment in XXXX surgery: the Big Five and the Milan Complexity Scale.

answer: @entity4


abstract: PURPOSE: This report reveals the results of a multicenter, randomized, controlled study using transurethral prostate convective water vapor thermal energy to treat lower urinary tract symptoms associated with @entity2 . MATERIALS AND METHODS: @entity0 50 years old or older with an International Prostate Symptom Score of 13 or greater, maximum flow rate of 15 ml per second or less and prostate size 30 to 80 cc were randomized 2:1 between thermal therapy with the Rez  m   System and control. Thermal water vapor was injected into the transition zone and median lobe as needed. The control procedure was rigid cystoscopy with simulated active treatment sounds. The primary end point compared International Prostate Symptom Score reduction at 3 months. Treatment subjects were followed for 12 months. RESULTS: There were 197 @entity0 randomized (active 136, control 61). Thermal therapy and control International Prostate Symptom Score was reduced by 11.2     7.6 and 4.3    6.9 respectively (p <0.0001). Treatment subject baseline International Prostate Symptom Score of 22 decreased at 2 weeks (18.6, p=0.0006) and by 50% or greater at 3, 6 and 12 months, p <0.0001. The peak flow rate increased by 6.2 ml per second at 3 months and was sustained throughout 12  months (p  <0.0001).  No de novo @entity1 was reported. Adverse events were mild to moderate and resolved quickly. CONCLUSIONS: Convective water vapor thermal therapy provides rapid and durable improvements in @entity2 symptoms and preserves erectile and ejaculatory function. Treatment can be delivered in an office or hospital setting using oral pain medication and is applicable to all prostate zones including the median lobe.

title: Minimally Invasive Prostate Convective Water Vapor Energy Ablation: A Multicenter, Randomized, Controlled Study for the Treatment of Lower Urinary Tract Symptoms Secondary to XXXX .

answer: @entity2


abstract: UNASSIGNED: Metabolomics is a new field of medicine focused on examining and analyzing metabolites produced in biological cells. Biological fluids primarily used in this method include: plasma, cerebrospinal fluid, saliva and urine. The most common methods of evaluating the composition involve nuclear magnetic resonance (NMR) and magnetic resonance (MR) with addition of gas chromatography (GC-MS) or liquid chromatography (LC-MS). Metabolomics is used in a wide variety of medicine disciplines. The variability of biochemical processes in @entity1 cells in comparison to normal cells is the starting point of such studies. The metabolomic changes are observed not only in solid @entity1 , like the @entity1 , @entity3 but also in @entity1 of the hematopoietic and lymphoid tissues. Nowadays, the aim of studies is to find biomarkers which would help to diagnose a disease quickly, assess its progression, and implement effective treatment. Metabolomics is also widely applied in @entity4 , mainly the @entity2 . The list of examined metabolites gives promising chances for a successful prognosis, diagnosis and comprehensive monitoring of the progression of this civilization disease. The development of metabolomics will also contribute to the individualization of treatment, proper drugs adjustment, which will make a therapy more successful, cause less side effects and improve the quality of @entity0 's life.

title: [The use of metabolomics in medicine - some examples of oncological and XXXX ].

answer: @entity4


abstract: BACKGROUND: @entity5 (ITZ), a @entity7 antifungal agent, is a poorly water-soluble drug that is orally administered for treatment of @entity3 such as @entity6 ( @entity6 ) and @entity1 ( @entity1 ). @entity6 is relatively well controlled but @entity1 can be fatal, especially in immunosuppressed @entity0 . Aerosolized ITZ delivered to the lung may provide a local treatment and prophylaxis against @entity1 at the primary site of infection in the lungs. Variations of the percent @entity4 ( @entity4 ), the percent emitted dose, and the physical properties of the aerosol (e.g., crystallinity) can confound consistent delivery. METHODS: ITZ NanoClusters were formulated via milling (top-down process) or precipitation (bottom-up process) without using any excipients. @entity5 formulations (ITZ) were prepared by milling 1 gram of micronized @entity5 in 300   mL of fluid. The suspension was collected at 0.5, 1, and 2 hours milling time. Milled ITZ was compared to ITZ prepared by anti-solvent precipitation and to the stock micronized @entity5 . The aerosolization performance of ITZ formulations was determined using an Andersen Cascade Impactor (ACI). RESULTS: The physicochemical properties and aerosol performance of different ITZ NanoClusters suggested an optimized wet milling was the preferred process compared to precipitation. ITZ NanoClusters prepared by wet milling showed better aerosol performance compared to micronized ITZ as received and ITZ NanoClusters prepared by precipitation. ITZ NanoClusters prepared by precipitation methods also showed an amorphous state, while ITZ milled in 10% @entity2 maintained the crystalline character of ITZ throughout a 2 hour milling time. CONCLUSIONS: The aerosol performance of milled ITZ NanoClusters was dramatically improved compared to micronized ITZ as received due to the difference of drug particle structures. ITZ NanoCluster formulations represent a potential engineered drug particle approach for inhalation therapy, providing effective aerosol properties and stability due to the crystalline state of the drug powders.

title: NanoCluster XXXX Formulations Provide a Potential Engineered Drug Particle Approach to Generate Effective Dry Powder Aerosols.

answer: @entity5


abstract: BACKGROUND AND AIMS: Increased carotid artery @entity5 ( @entity5 ) and the presence of plaques have been shown to be predictors of @entity2 . The cardiovascular risk in @entity0 with overt @entity9 is related to increased risk of @entity8 , but there has been no clear evidence about @entity3 . We have assessed whether subclinical @entity9 is associated with arterial thickening and plaque. METHODS AND RESULTS: The SardiNIA study is a population-based survey on the Italian island of Sardinia. We reviewed data from 5815 subjects (aged 14-102 years), none of whom had overt @entity11 or @entity10 or was taking thyroid medication. Serum thyrotropin (TSH), free @entity12 , together with carotid ultrasound @entity5 and the presence of common carotid plaques were analysed in all subjects. Possible association of @entity5 and carotid plaques with thyroid parameters was evaluated by univariate and multivariate analyses. @entity5 was significantly associated with age, sex, smoking, low density lipoprotein @entity6 (LDL), high density lipoprotein @entity6 , pulse pressure (PP), history of arterial @entity4 , @entity1 , and previous @entity2 (p  =  0.001 or lower, R(2)  =  0.47). Carotid plaques were predicted by age, sex, LDL, PP, history of @entity1 , previous @entity2 , and the use of statins (p  =  0.029 or lower). Thyroid hormone was not predictive of @entity13 when adjusted for confounders. CONCLUSION: Thyroid hormone is not associated with increased @entity5 or with the presence of @entity7 . Our data do not support the idea that treating @entity3 might help to prevent arterial remodelling or @entity13 .

title: No evidence of association between subclinical XXXX and common carotid intima medial thickness or @entity8 plaque.

answer: @entity9


abstract: BACKGROUND AND AIMS: Increased carotid artery @entity5 ( @entity5 ) and the presence of plaques have been shown to be predictors of @entity2 . The cardiovascular risk in @entity0 with overt @entity9 is related to increased risk of @entity8 , but there has been no clear evidence about @entity3 . We have assessed whether subclinical @entity9 is associated with arterial thickening and plaque. METHODS AND RESULTS: The SardiNIA study is a population-based survey on the Italian island of Sardinia. We reviewed data from 5815 subjects (aged 14-102 years), none of whom had overt @entity11 or @entity10 or was taking thyroid medication. Serum thyrotropin (TSH), free @entity12 , together with carotid ultrasound @entity5 and the presence of common carotid plaques were analysed in all subjects. Possible association of @entity5 and carotid plaques with thyroid parameters was evaluated by univariate and multivariate analyses. @entity5 was significantly associated with age, sex, smoking, low density lipoprotein @entity6 (LDL), high density lipoprotein @entity6 , pulse pressure (PP), history of arterial @entity4 , @entity1 , and previous @entity2 (p  =  0.001 or lower, R(2)  =  0.47). Carotid plaques were predicted by age, sex, LDL, PP, history of @entity1 , previous @entity2 , and the use of statins (p  =  0.029 or lower). Thyroid hormone was not predictive of @entity13 when adjusted for confounders. CONCLUSION: Thyroid hormone is not associated with increased @entity5 or with the presence of @entity7 . Our data do not support the idea that treating @entity3 might help to prevent arterial remodelling or @entity13 .

title: No evidence of association between subclinical @entity9 and common carotid intima medial thickness or XXXX plaque.

answer: @entity8


abstract: BACKGROUND: Controversy exists regarding the predictive ability of a negative sentinel lymph node biopsy (SLNB) and the use of adjuvant radiation in @entity2 ( @entity2 ). METHODS: Retrospective study of @entity0 with @entity2 undergoing SLNB at Mayo Clinic from 1995 to 2011. Cumulative incidence (CI) of regional recurrence and @entity1 from @entity2 , respectively, were estimated taking into account the competing risk of @entity1 from other causes and compared between groups using Gray's test. RESULTS: A total of 111 (74  %) of 150 SLNB were negative and comprised our study group. There were 15 regional recurrences, and the CI of a regional recurrence was 5.1, 15.0, and 16.6  % at 1, 3, and 5  years, respectively, after initial surgery. Nine @entity0 (8  % of all @entity0 ) experienced a same nodal basin recurrence after a negative SLNB. Among 14 @entity0 who received nodal radiation, the CI of a regional recurrence was 0 and 9.1  % at 1 and 3  years, respectively, compared to 5.8 and 15.5  %, respectively, among the 97 who did not receive nodal radiation (p  =  0.45). Male sex was the only characteristic predictive of regional recurrence after a negative SLNB; the CI at 3  years was 21.3 versus 0  % in @entity0 and @entity0 , respectively (p  =  0.007). Head and neck location was not associated with a higher risk of recurrence or an improvement in regional recurrences after radiation. CONCLUSIONS: Same nodal basin recurrences are uncommon after SLNB in @entity2 , and regional nodal irradiation can be avoided in the setting of successful sentinel lymph node mapping and a negative SLNB.

title: Negative Sentinel Lymph Node XXXX is Associated with a Low Risk of Same-Nodal-Basin Recurrences.

answer: @entity2


abstract: BACKGROUND: A primary @entity2 ( @entity2 ) arising from sternum is quite uncommon @entity1 in thoracic surgery. @entity1 requires extensive resection of the anterior chest wall, and results in @entity5 . CASE PRESENTATION: A 40-year-old  female presented a progressively enlarging mass of her anterior chest wall. Computed tomography revealed an @entity3 with discrete @entity6 in the bone marrow of the sternum. The @entity1 extended across the destroyed cortex to the parietal and visceral soft aspects, involving some of the costal cartilage and most of the sternal body. Partial sternal resection was performed successfully and an individual-specific stainless steel plate was used to reconstruct the anterior chest wall. The early result was good, however, nine months after the first surgery, fractures of plate were found at bilateral plate-clavicular junction. The plate had to be removed, and a @entity4 mesh was used to reconstruction of the chest wall. The @entity0 has been of disease free for more than 18  month after the second surgery. CONCLUSIONS: Our experience indicated that the individual-specific plate may not be suitable for reconstructing both the anterior chest wall as well as the sternoclavicular joint after subtotal sternum resection.

title: Surgical management of a XXXX : a case report.

answer: @entity2


abstract: UNASSIGNED: In a thermally driven rotary motor made from double-walled @entity0 nanotubes, the @entity2 (inner tube) can be actuated to rotate within the stator (outer tube) when the environmental temperature is high enough. A sudden stoppage of the @entity2 can occur when the inner tube has been actuated to rotate at a stable high speed. To find the mechanisms of such sudden stoppages, eight motor models with the same @entity2 but different stators are built and simulated in the canonical NVT ensembles. Numerical results demonstrate that the sudden stoppage of the @entity2 occurs when the difference between radii is near 0.34 nm at a high environmental temperature. A smaller difference between radii does not imply easier activation of the @entity1 . During rotation, the positions and electron density distribution of atoms at the ends of the motor show that a sp(1) bonded atom on the @entity2 is attracted by the sp(1) atom with the biggest deviation of radial position on the stator, after which they become two sp(2) atoms. The strong bond interaction between the two atoms leads to the loss of rotational speed of the @entity2 within 1 ps. Hence, the sudden stoppage is attributed to two factors: the deviation of radial position of atoms at the stator's ends and the drastic thermal vibration of atoms on the @entity2 in rotation. For a stable motor, sudden stoppage could be avoided by reducing deviation of the radial position of atoms at the stator's ends. A nanobrake can be, thus, achieved by adjusting a sp(1) atom at the ends of stator to stop the rotation of @entity2 quickly.

title: @entity1 in a thermally driven rotary motor made from double-walled XXXX nanotubes.

answer: @entity0