abstract: BACKGROUND: The definition of @entity4 ( @entity4 ) was proposed because of its clinical relevance. @entity4 relates to subsequent therapeutic failure which results in the modification of the regimen. Whether this rationale can be applied to all @entity2 analogues (NA) is not clear. This study was undertaken to analyze @entity4 influence on therapeutic outcomes during @entity6 , @entity7 or @entity5 monotherapy in NA-naive @entity0 with @entity3 in routine clinical practice. METHODS: We retrospectively analyzed 150 NA-naive @entity0 with @entity3 . These subjects received @entity6 , @entity7 or @entity5 monotherapy between February 2001 and July 2013. RESULTS: Sixty-nine @entity0 were treated with @entity6 , 35 with @entity7 , and 46 with @entity5 . The median therapeutic duration was 19.5 (6-147) months. @entity4 rates at 24 weeks were similar among three @entity1 ( @entity6 33.3%, @entity7 35.0%, @entity5 32.4%, P=0.981). For all three NAs, @entity0 with a higher baseline viral load or HBeAg-positive status had a higher serum viral positive rate tested by polymerase chain reaction at week 24 and 48. Cumulative probability of virological breakthrough (VBR) for @entity0 treated with @entity6 was 67% at 5 years, and @entity4 at 24 weeks was the independent risk factor for VBR (HR: 3.09; 95% CI: 1.09-8.74; P=0.034); also @entity6 treated @entity0 older than 50 years seemed to have a tendency for VBR (HR: 2.80; 95% CI: 0.99-8.18; P=0.052). A majority of @entity7 and @entity5 partial responders achieved and maintained virological response with prolonged monotherapy, except one @entity7 treated @entity0 who experienced VBR due to resistance mutations. CONCLUSIONS: Management strategy for @entity6 treatment should include adaptation of regimen according to @entity4 as an on-treatment response parameter due to its relation with unacceptably high VBR probability. Similar conclusion should not be directly related to @entity7 or @entity5 treatment.

title: Partial virological response to three different @entity2 analogues in naive @entity0 with XXXX .

answer: @entity3


abstract: BACKGROUND: The definition of @entity4 ( @entity4 ) was proposed because of its clinical relevance. @entity4 relates to subsequent therapeutic failure which results in the modification of the regimen. Whether this rationale can be applied to all @entity2 analogues (NA) is not clear. This study was undertaken to analyze @entity4 influence on therapeutic outcomes during @entity6 , @entity7 or @entity5 monotherapy in NA-naive @entity0 with @entity3 in routine clinical practice. METHODS: We retrospectively analyzed 150 NA-naive @entity0 with @entity3 . These subjects received @entity6 , @entity7 or @entity5 monotherapy between February 2001 and July 2013. RESULTS: Sixty-nine @entity0 were treated with @entity6 , 35 with @entity7 , and 46 with @entity5 . The median therapeutic duration was 19.5 (6-147) months. @entity4 rates at 24 weeks were similar among three @entity1 ( @entity6 33.3%, @entity7 35.0%, @entity5 32.4%, P=0.981). For all three NAs, @entity0 with a higher baseline viral load or HBeAg-positive status had a higher serum viral positive rate tested by polymerase chain reaction at week 24 and 48. Cumulative probability of virological breakthrough (VBR) for @entity0 treated with @entity6 was 67% at 5 years, and @entity4 at 24 weeks was the independent risk factor for VBR (HR: 3.09; 95% CI: 1.09-8.74; P=0.034); also @entity6 treated @entity0 older than 50 years seemed to have a tendency for VBR (HR: 2.80; 95% CI: 0.99-8.18; P=0.052). A majority of @entity7 and @entity5 partial responders achieved and maintained virological response with prolonged monotherapy, except one @entity7 treated @entity0 who experienced VBR due to resistance mutations. CONCLUSIONS: Management strategy for @entity6 treatment should include adaptation of regimen according to @entity4 as an on-treatment response parameter due to its relation with unacceptably high VBR probability. Similar conclusion should not be directly related to @entity7 or @entity5 treatment.

title: Partial virological response to three different @entity2 analogues in naive XXXX with @entity3 .

answer: @entity0


abstract: UNASSIGNED: Background: Peritonitis from perforation of abdominal viscera is associated with high mortality. In western countries individuals older than 65 years constitute a significant proportion of the population and @entity3 are more challenging to manage in these aged @entity0 . Methods: This prospective cohort study included 143 consecutive @entity0 operated on for primary perforative @entity2 . The aim of the study was to assess the prognostic efficacy of @entity2 Index (MPI) in a population with a significant proportion of older @entity0 and to substantiate advanced age as an independent prognostic factor. @entity0 ' informations were collected both on hospitalization and after surgical exploration; severity of @entity2 was evaluated using the MPI. The prognostic value of MPI was compared to older age and other clinical variables. Results: The intra-hospital mortality was 25.2%. According to the MPI score, the ROC curve identified 21 as cut-off value with a sensitivity of 86% and a specificity of 59% in predicting the risk of @entity1 . MPI score and age over 80 years old resulted independent predictors of mortality at multivariate analysis. In the subgroup of @entity0 with MPI score >= 21, the mortality rate was 46.4% for @entity0 older than 80 years old and 38.3% for younger @entity0 (p  =  0.07); in @entity0 with MPI score <21, the mortality of those aged more than 80 years reached 33.3% compared to 3.4% for younger @entity0 (p  =  0.001). Conclusions: Age older than 80 years is strongly related to major increase in mortality rates and should be taken into account together with the MPI score in planning the surgical approach and the post-operative care.

title: Re-evaluation of Mannheim prognostic index in perforative XXXX : Prognostic role of advanced age. A prospective cohort study.

answer: @entity2


abstract: INTRODUCTION: Adolescents go through a phase characterised by physical, mental, psychological and social changes which justify periods of hostile behaviours. The occurrence and intensity of these behaviours may correspond to a psychopathological condition that will affect their future lives. The aim of this research is to identify the socio-demographic and family background variables that influence hostile behaviours in adolescents and to analyse the influence of @entity2 and @entity1 in hostile behaviours in adolescents. METHODS: This is a quantitative, non-experimental, cross-sectional, descriptive, correlational study with epidemiological characteristics. The sample consists of 1890 adolescents, 863 (45.7%) @entity0 and 1027 (54.3%) @entity0 whose average age is 16.26 years. The data collection instrument includes the socio-demographic and family background and @entity1 , @entity2 and hostile behaviours in adolescence measurement scales: the State-Trait @entity1 Scale, the @entity2 Scale and the Buss-Durkee Hostility Inventory. RESULTS: We found that the prevalent group is between 17 and 21 years old (40.3%) 41.4% @entity0 and 39.4% @entity0 ; the highest percentage of the adolescents (37.8%) are in the 10th year of schooling; 50.7% live in the city, 70.0% live with their parents; the monthly household income is medium-high (56.7%) for (56.5%) @entity0 ; 3.5% of the adolescents exhibit @entity2 , mostly @entity0 who are 17 or older; @entity0 have higher levels of @entity1 -trait and @entity0 of @entity1 . CONCLUSIONS: We may conclude that only @entity2 has a relationship with hostile behaviours. It is higher in adolescents with these behaviours. The presence or absence of @entity1 is not related to the hostile behaviour in adolescents.

title: XXXX and @entity2 in adolescents with hostile behaviour.

answer: @entity1


abstract: INTRODUCTION: Adolescents go through a phase characterised by physical, mental, psychological and social changes which justify periods of hostile behaviours. The occurrence and intensity of these behaviours may correspond to a psychopathological condition that will affect their future lives. The aim of this research is to identify the socio-demographic and family background variables that influence hostile behaviours in adolescents and to analyse the influence of @entity2 and @entity1 in hostile behaviours in adolescents. METHODS: This is a quantitative, non-experimental, cross-sectional, descriptive, correlational study with epidemiological characteristics. The sample consists of 1890 adolescents, 863 (45.7%) @entity0 and 1027 (54.3%) @entity0 whose average age is 16.26 years. The data collection instrument includes the socio-demographic and family background and @entity1 , @entity2 and hostile behaviours in adolescence measurement scales: the State-Trait @entity1 Scale, the @entity2 Scale and the Buss-Durkee Hostility Inventory. RESULTS: We found that the prevalent group is between 17 and 21 years old (40.3%) 41.4% @entity0 and 39.4% @entity0 ; the highest percentage of the adolescents (37.8%) are in the 10th year of schooling; 50.7% live in the city, 70.0% live with their parents; the monthly household income is medium-high (56.7%) for (56.5%) @entity0 ; 3.5% of the adolescents exhibit @entity2 , mostly @entity0 who are 17 or older; @entity0 have higher levels of @entity1 -trait and @entity0 of @entity1 . CONCLUSIONS: We may conclude that only @entity2 has a relationship with hostile behaviours. It is higher in adolescents with these behaviours. The presence or absence of @entity1 is not related to the hostile behaviour in adolescents.

title: @entity1 and XXXX in adolescents with hostile behaviour.

answer: @entity2


abstract: This study investigated the relationships among intraocular pressure (IOP), @entity2 (NO) levels, and aqueous flow rates in experimental @entity5 models. A total of 75 @entity1 were used. One of four different materials [i.e., a-chymotrypsin, latex microspheres (Polybead), red blood cell ghosts, or @entity6 (Healon GV)] was injected into the eyes of the 15 animals in each experimental group; the remaining 15 @entity1 were reserved for a control group. The IOP changes in the five groups were recorded on postinduction Days 1-3, Day 7, Day 14, Day 30, Day 60, Day 90, and Day 120. On postinduction Day 7, the dynamics and NO levels in the @entity7 were recorded. Significant IOP elevations were induced by a-chymotrypsin (p  <  0.01) and Polybead (p  <  0.01) on each postinduction day. In the red blood cell ghosts model, significant elevations (p  <  0.01) were found on postinduction Days 1-3; Healon GV significantly elevated IOP (p  <  0.01) on postinduction Day 1 and Day 2. On postinduction Day 7, the @entity7 NO levels increased significantly in the models of a-chymotrypsin, Polybead, and red blood cell ghosts (all p  <  0.01), while the aqueous flow rates were significantly reduced in the models of a-chymotrypsin and Polybead (p  <  0.005). Persistent @entity5 models were induced with a-chymotrypsin and Polybead in the @entity1 . The Polybead model exhibited the characteristic of an increased @entity7 NO level, similar to @entity0 eyes with @entity4 and @entity3 .

title: @entity2 levels in the @entity7 vary in different XXXX experimental models.

answer: @entity5


abstract: This study investigated the relationships among intraocular pressure (IOP), @entity2 (NO) levels, and aqueous flow rates in experimental @entity5 models. A total of 75 @entity1 were used. One of four different materials [i.e., a-chymotrypsin, latex microspheres (Polybead), red blood cell ghosts, or @entity6 (Healon GV)] was injected into the eyes of the 15 animals in each experimental group; the remaining 15 @entity1 were reserved for a control group. The IOP changes in the five groups were recorded on postinduction Days 1-3, Day 7, Day 14, Day 30, Day 60, Day 90, and Day 120. On postinduction Day 7, the dynamics and NO levels in the @entity7 were recorded. Significant IOP elevations were induced by a-chymotrypsin (p  <  0.01) and Polybead (p  <  0.01) on each postinduction day. In the red blood cell ghosts model, significant elevations (p  <  0.01) were found on postinduction Days 1-3; Healon GV significantly elevated IOP (p  <  0.01) on postinduction Day 1 and Day 2. On postinduction Day 7, the @entity7 NO levels increased significantly in the models of a-chymotrypsin, Polybead, and red blood cell ghosts (all p  <  0.01), while the aqueous flow rates were significantly reduced in the models of a-chymotrypsin and Polybead (p  <  0.005). Persistent @entity5 models were induced with a-chymotrypsin and Polybead in the @entity1 . The Polybead model exhibited the characteristic of an increased @entity7 NO level, similar to @entity0 eyes with @entity4 and @entity3 .

title: @entity2 levels in the XXXX vary in different @entity5 experimental models.

answer: @entity7


abstract: This study investigated the relationships among intraocular pressure (IOP), @entity2 (NO) levels, and aqueous flow rates in experimental @entity5 models. A total of 75 @entity1 were used. One of four different materials [i.e., a-chymotrypsin, latex microspheres (Polybead), red blood cell ghosts, or @entity6 (Healon GV)] was injected into the eyes of the 15 animals in each experimental group; the remaining 15 @entity1 were reserved for a control group. The IOP changes in the five groups were recorded on postinduction Days 1-3, Day 7, Day 14, Day 30, Day 60, Day 90, and Day 120. On postinduction Day 7, the dynamics and NO levels in the @entity7 were recorded. Significant IOP elevations were induced by a-chymotrypsin (p  <  0.01) and Polybead (p  <  0.01) on each postinduction day. In the red blood cell ghosts model, significant elevations (p  <  0.01) were found on postinduction Days 1-3; Healon GV significantly elevated IOP (p  <  0.01) on postinduction Day 1 and Day 2. On postinduction Day 7, the @entity7 NO levels increased significantly in the models of a-chymotrypsin, Polybead, and red blood cell ghosts (all p  <  0.01), while the aqueous flow rates were significantly reduced in the models of a-chymotrypsin and Polybead (p  <  0.005). Persistent @entity5 models were induced with a-chymotrypsin and Polybead in the @entity1 . The Polybead model exhibited the characteristic of an increased @entity7 NO level, similar to @entity0 eyes with @entity4 and @entity3 .

title: XXXX levels in the @entity7 vary in different @entity5 experimental models.

answer: @entity2


abstract: Elderly @entity0 are more susceptible to @entity2 . However, many of them are poor surgical candidates and often have to undergo endovascular treatment. The purpose of this study was to evaluate the efficacy and safety of double-microcatheter technique as an alternative to a balloon- or stent-assisted techniques for @entity3 in elderly @entity0 . A retrospective review of 58 @entity0 with 58 @entity3 treated with the double-microcatheter technique between October 2010 and December 2012 was performed. Immediate post-embolization angiograms were evaluated using a conventional angiographic scale, and clinical evaluation was performed using the Glasgow Outcome Scale. Clinical and imaging follow-ups were available in 32 (55  %) @entity0 , with a mean of 12.5  months. Post-embolization angiograms demonstrated @entity1 in 46 of 58 (79  %) @entity3 , a neck remnant in 7 (13  %), and body filling in 5 (8  %). The technique-related complication rate was 5  % (3/58), and the procedural-related mortality rate was 0. Of the 32 @entity3 with follow-ups, recanalization developed in 3 (9  %) @entity3 , and none received re-treatment. Using double-microcatheter technique for embolization of wide-neck @entity2 is safe and effective in the elderly @entity0 . This technique is feasible and safe for coil embolization of @entity3 , especially in cases, which are not suitable for balloon- or stent-assisted techniques.

title: Improved Endovascular Coiling of Wide-Neck XXXX in Elderly @entity0 by Double-Microcatheter Technique.

answer: @entity2


abstract: Elderly @entity0 are more susceptible to @entity2 . However, many of them are poor surgical candidates and often have to undergo endovascular treatment. The purpose of this study was to evaluate the efficacy and safety of double-microcatheter technique as an alternative to a balloon- or stent-assisted techniques for @entity3 in elderly @entity0 . A retrospective review of 58 @entity0 with 58 @entity3 treated with the double-microcatheter technique between October 2010 and December 2012 was performed. Immediate post-embolization angiograms were evaluated using a conventional angiographic scale, and clinical evaluation was performed using the Glasgow Outcome Scale. Clinical and imaging follow-ups were available in 32 (55  %) @entity0 , with a mean of 12.5  months. Post-embolization angiograms demonstrated @entity1 in 46 of 58 (79  %) @entity3 , a neck remnant in 7 (13  %), and body filling in 5 (8  %). The technique-related complication rate was 5  % (3/58), and the procedural-related mortality rate was 0. Of the 32 @entity3 with follow-ups, recanalization developed in 3 (9  %) @entity3 , and none received re-treatment. Using double-microcatheter technique for embolization of wide-neck @entity2 is safe and effective in the elderly @entity0 . This technique is feasible and safe for coil embolization of @entity3 , especially in cases, which are not suitable for balloon- or stent-assisted techniques.

title: Improved Endovascular Coiling of Wide-Neck @entity2 in Elderly XXXX by Double-Microcatheter Technique.

answer: @entity0


abstract: Wertheim radical hysterectomy combined with pelvic lymphadenectomy was performed at the Helsinki University Central Hospital on 132 @entity0 of whom 120 had @entity3 from Stage IA to early IIB and 12 had @entity2 Stage II. None of the @entity0 died or had severe complications during their hospitalisation. The left ureter was accidently transected in two @entity0 and both were corrected immediately. Wound complications occurred in 16 @entity0 (12%). The high incidence of wound complications is probably partly related to the low-dose heparin prophylaxis. The initial clinical staging was found to be correct in 85% of the cases. Five cases were under-staged. All ten @entity0 cases of early Stage IIB were over-staged, none of whom had parametrial invasion. The predictive value of lymphangiography was low, 14% in histologically positive cases and 89% in negative cases of lymph node @entity1 . Lymphangiography proved to be only of value in facilitating complete lymph node dissection. Intra-operative lymphangiographic control revealed radio-positive nodes and lead to further dissection in 30 @entity0 (24%).

title: Wertheim radical hysterectomy. Surgical complications, accuracy of clinical staging and value of XXXX .

answer: @entity3


abstract: Many outpatients who inadequately prepared for the procedure were cancelled on the day of the examination for various reasons. The aim of study was to investigate whether @entity1 ( @entity1 ) can improve @entity0 ' compliance and reduce cancellation rates. Outpatients scheduled for sedation gastrointestinal endoscopy were randomly assigned to mobile phone @entity1 group or control group. @entity0 in the control group received a leaflet on preparation instructions, while @entity0 in the @entity1 group received @entity1 reminders after making an appointment. A total of 1786 @entity0 were analyzed. There was a significant @entity2 for @entity0 in the @entity1 group (4.8  %) compared with @entity0 in the control group (8.0  %) (P   <   0.001). @entity0 in the @entity1 group were 40  % less likely to be cancelled by medical staff than @entity0 in the control group. The compliance score of the two groups based on demographic and clinic characteristic distribution showed that for both male and female @entity0 , the compliance score was higher in the @entity1 group than that in the control group (P   =   0.023, P   <   0.001, respectively). Additionally, the compliance score was also significantly higher in the @entity1 group among @entity0 who were under 50  years old, less than an undergraduate education level, experiencing their first time for procedure, or whose procedures were gastroscopy, waiting time was between 4 and 15  days, and schedules were in morning (P    <=   0.032). @entity1 reminders can be considered a complement to conventional preparation instructions, which could help improve the compliance of outpatients and reduce the rate of cancellations.

title: XXXX ( @entity1 ) can Enhance Compliance and Reduce Cancellations in a Sedation Gastrointestinal Endoscopy Center: A Prospective Randomized Controlled Trial.

answer: @entity1


abstract: Many outpatients who inadequately prepared for the procedure were cancelled on the day of the examination for various reasons. The aim of study was to investigate whether @entity1 ( @entity1 ) can improve @entity0 ' compliance and reduce cancellation rates. Outpatients scheduled for sedation gastrointestinal endoscopy were randomly assigned to mobile phone @entity1 group or control group. @entity0 in the control group received a leaflet on preparation instructions, while @entity0 in the @entity1 group received @entity1 reminders after making an appointment. A total of 1786 @entity0 were analyzed. There was a significant @entity2 for @entity0 in the @entity1 group (4.8  %) compared with @entity0 in the control group (8.0  %) (P   <   0.001). @entity0 in the @entity1 group were 40  % less likely to be cancelled by medical staff than @entity0 in the control group. The compliance score of the two groups based on demographic and clinic characteristic distribution showed that for both male and female @entity0 , the compliance score was higher in the @entity1 group than that in the control group (P   =   0.023, P   <   0.001, respectively). Additionally, the compliance score was also significantly higher in the @entity1 group among @entity0 who were under 50  years old, less than an undergraduate education level, experiencing their first time for procedure, or whose procedures were gastroscopy, waiting time was between 4 and 15  days, and schedules were in morning (P    <=   0.032). @entity1 reminders can be considered a complement to conventional preparation instructions, which could help improve the compliance of outpatients and reduce the rate of cancellations.

title: @entity1 ( XXXX ) can Enhance Compliance and Reduce Cancellations in a Sedation Gastrointestinal Endoscopy Center: A Prospective Randomized Controlled Trial.

answer: @entity1


abstract: OBJECTIVE: To investigate the efficacy of infliximab versus corticosteroids in achieving clinical remission in pediatric @entity0 with @entity1 in China. METHOD: Data of all newly diagnosed active @entity1 pediatric cases seen from June 2009 to December 2013 in @entity0 's Hospital, Zhejiang University School of @entity6 were retrospectively recorded and reviewed. INCLUSION CRITERIA: the age of the @entity0 was less than 18 years; pediatric @entity1 activity index (PCDAI) was more than 10; infliximab or corticosteroids were used for inducing remission; infliximab, immunosuppressive medications or @entity7 was prescribed for maintaining remission. @entity0 in @entity3 group were followed up for more than 1 year. The enrolled @entity0 were divided into two groups: infliximab group and @entity3 group. Clinical data, laboratory findings and side effects of the medications were collected at week 2, 4, 12, 24 and 48. PCDAI and @entity1 endoscopic index score (CDEIS) were calculated. Clinical response rate, clinical remission rate, relapse rate, @entity2 and growth were evaluated. RESULT: Eleven @entity0 received infliximab therapy and 11 subjects received corticosteroids. In Infliximab group, 6, 5 and 7 @entity0 were in clinical remission at week 2, 4, and 8, while so were 6, 9, and 9 @entity0 in @entity3 group. The difference was not statistically significant (     = 0.00, 3.14, 0.92, P > 0.05). In infliximab group, 8, 8, and 11 @entity0 were in clinical remission at week 2, 4, and 8, so were 8, 9, and 9 @entity0 in @entity3 group. The difference was not statistically significant (     = 0.00,0.26, 2.20, P > 0.05). When compared with data at baseline, significant decreases were observed in the median PCDAI between the two groups at week 2, 4, and 8 (all P < 0.05). But there were no significant differences between two groups at week 2, 4, and 8 (all P > 0.05). At week 12, 24 and 48, 8/11, 7/8, 3/5 cases on infliximab versus 7/11, 9/11, 8/11 cases on @entity3 maintained remission. There was no significant differences between the two groups (all P > 0.05). In 7 @entity0 and 9 @entity0 remission was successfully induced at week 8. The relapse rate was similar at week 12, 24, and 48 (     = 0.83, 0.09, 1.00, all P > 0.05). Height for age Z score in infliximab group was significantly higher than that in @entity3 group at week 24 (P < 0.05). Body mass index Z score between the two groups at week 8, 24, and 48 were not statistically significant (all P > 0.05). Of the @entity0 treated with infliximab, 3 developed side effects. All the @entity0 treated with @entity3 got @entity5 . CONCLUSION: In @entity0 with @entity1 , infliximab therapy is as effective as @entity4 to induce remission.Less side effects were observed with infliximab therapy compared with immunosuppressive medication and @entity7 .

title: [Efficacy of infliximab in treatment of pediatric XXXX in China].

answer: @entity1


abstract: BACKGROUND: Clinical @entity2 in endemic countries is treated with a single dose of @entity1 per 40 mg/kg body weight. Treating according to weight, in resource-poor settings when thousands of doses are to be administered in mass treatment campaigns, is considered problematic. A calibrated dose-pole based on height was developed and is now used in mass treatment campaigns for determining the doses for schoolchildren. The dose-pole will generate dose errors since every @entity0 population contains individuals that are either short or tall for weight. The aim of this study is to explore whether the WHO @entity1 pole is a satisfactory dose instrument for mass treatment of @entity3 . METHODS: In 1996 and 2002, 1,694 @entity0 were surveyed in the Kilimanjaro Region, Tanzania. We compared doses given by weight to doses given by height using descriptive statistics and regression. CONCLUSIONS AND INTERPRETATION: The WHO dose-pole for @entity1 is based on height of the @entity0 ; however, @entity0 with the same height will differ in weight. Our study shows that @entity0 with the same weight could qualify for up to four different dose levels based on their height. The largest variation of doses based on the WHO dose-pole will be found in @entity0 below 20 kg of bodyweight. Using bodyweight and tablet halves as the smallest tablet division unit to determine the doses of @entity1 , one only has to identify every 6th kilogram of bodyweight; the doses will then vary a lot less than when using the WHO dose-pole.

title: From a weighing scale to a pole: a comparison of two different dosage strategies in mass treatment of XXXX haematobium.

answer: @entity2


abstract: Phytoremediation of sites contaminated with iron cyanides can be performed using poplar and willow trees. Poplar and willow trees were grown in potting substrate spiked with @entity2 concentrations of up to 2,000  mg  kg(-1) for 4 and 8  weeks respectively. Soil solution and leaf tissue of different age were sampled for total @entity1 analysis every week. Chlorophyll content in the leaves was determined to quantify @entity1 @entity0 . Results showed that @entity1 in the soil solution of spiked soils differed between treatments and on weekly basis and ranged from 0.5 to 1,200  mg  l(-1). The maximum @entity1 content in willow and poplar leaves was 518  mg  kg(-1) fresh weight (FW) and 148  mg  kg(-1) FW respectively. @entity1 accumulated in the leaves increased linearly with increasing @entity1 concentration in the soil solution. On the long term, significantly more @entity1 was accumulated in old leaf tissue than in young tissue. Chlorophyll content in poplar decreased linearly with increasing @entity1 in the soil solution and in leaf tissue, and over time. The inhibitory concentration (IC50) value for poplars after 4  weeks of exposure was 173  mg  l(-1) and for willow after 8  weeks of exposure-768  mg  l(-1). Results show that willows tolerate much more @entity1 and over a longer period than poplars, making them very appropriate for remediating sites highly contaminated with iron cyanides.

title: Uptake of XXXX in willow and poplar trees in a long term greenhouse experiment.

answer: @entity2


abstract: OBJECTIVE: To examine perceptions of medical doctor behavior in @entity2 ( @entity2 ) utilization disparities. DATA SOURCES: Secondary data analyses of the National Comorbidity Survey-Replication and the National Latino and Asian American Study (2001-2003). STUDY DESIGN: Sample included non-Hispanic whites (NHWs), blacks, Asians, and Latinos. Dependent variables were @entity0 reports of providers' assessment of and counseling on @entity2 and @entity1 ( @entity1 ) problems, and recommendation for medications or specialty @entity2 care. The initial sample consisted of 9,100 adults; the final sample included the 3,447 individuals who had been asked about @entity2 and @entity1 problems. PRINCIPAL FINDINGS: Bivariate analyses indicated that Asians were the least likely to report being assessed, counseled, and recommended medications and specialty care. In multivariate logistic regression analyses, there were no racial/ethnic differences in assessment of @entity2 or @entity1 problems. Compared to NHWs, black @entity0 were less likely to report receiving a medication recommendation. Latinos were more likely to report counseling and a recommendation to specialty care. U.S.-born @entity0 were more likely to report a medication recommendation. CONCLUSIONS: Perceptions of provider behavior might contribute to documented disparities in @entity2 utilization. Further research is needed to determine other points in the treatment utilization process that might account for racial/ethnic disparities.

title: Disparities in Assessment, Treatment, and Recommendations for Specialty Mental Health Care: XXXX Reports of Medical Provider Behavior.

answer: @entity0


abstract: @entity1 and @entity4 still represent the leading cause of mortality in developed countries. Therefore, great efforts have been made in the last decades to improve reperfusion strategies and adjunctive antithrombotic therapies. In fact, despite optimal epicardial recanalisation, a large proportion of @entity0 still experience impaired reperfusion and in-stent @entity5 . The adjunctive use of glycoprotein (GP) IIb-IIIa inhibitors may certainly contribute in the @entity2 , especially when administered in the early phase of @entity6 . In fact, in this phase a larger platelet composition of the @entity5 and the presence of a larger amount of viable myocardium, as compared to a delayed phase, may increase the benefits from this therapy and counterbalance the potential higher risk of @entity3 . A large body of evidence has been accumulated on the benefits from @entity7 -IIIa inhibitors in terms of prevention of stent @entity5 , and benefits in mortality, especially among high-risk @entity0 and as upstream strategy. Therefore, based on current available data, @entity7 -IIIa inhibitors can be recommended as early as possible (upstream strategy) among high-risk @entity0 , such as those with advanced Killip class or anterior @entity4 ( @entity4 ), and those presenting within the first three hours. Even though it is not universally accepted, in our opinion this strategy should be implemented in a pre-hospital setting (in ambulance) or at first hospital admission (Emergency Room or Coronary Care Unit, irrespective of whether they are in the spoke or hub hospitals). Peri-procedural intracoronary administration of @entity7 -IIIa inhibitors has not provided additional benefits as compared to intravenous administration and therefore cannot be recommended. Even though the vast majority of trials have been conducted with abciximab, several meta-analyses comparing small molecules (mainly high-dose tirofiban rather than eptifibatide) versus abciximab showed similar angiographic and clinical results between the molecules. Several recent investigations and meta-analyses have documented the higher risk of stent @entity5 associated with bivalirudin as compared to unfractionated heparin (UFH). Being that these results are independent from the use of @entity7 -IIIa inhibitors, UFH should still remain the anticoagulation therapy of choice in @entity4 ( @entity4 ) @entity0 . Minimisation of @entity3 complications by extensive use of the radial approach, in the setting of @entity4 , may further contribute to the adoption of a more aggressive antithrombotic and antiplatelet therapy incorporating the use of @entity7 -IIIa inhibitors. The establishment of dedicated networks for @entity4 , and the large @entity4 campaign, will certainly contribute to increase the proportion of @entity0 presenting at first medical contact within the early phase (3  h) of @entity6 and therefore highly suitable for a more aggressive pharmacoinvasive approach with upstream administration of @entity7 -IIIa inhibitors. In fact, although the current therapeutic targets of increased rates of timely reperfusion, mainly by primary percutaneous coronary intervention (PCI), has been achieved, a deep look into the future in the fight against @entity4 will certainly put aborting @entity6 as the major desirable target to be achieved.

title: Platelet XXXX -IIIa Receptor Antagonists in Primary Angioplasty: Back to the Future.

answer: @entity7


abstract: Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in @entity0 with @entity2 2 @entity1 inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(  ) meal-mediated gastric electrical stimulation in @entity0 with @entity2 2 @entity1 . The study was a 48  week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMOND(  ) implanted @entity0 with @entity2 2 @entity1 with no activation of the electrical stimulation (placebo) versus meal-mediated activation of the electrical signal. The endpoint was improvement in glycemic control (HbA1c) from baseline to 24 and 48  weeks. In period 1 (0-24  weeks), equal improvement in HbA1c occurred independent of whether the meal-mediated electrical stimulation was turned on or left off (HbA1c -0.80% and -0.85% [-8.8 and -9.0  mmol/mol]). The device placebo improvement proved to be transient as it was lost in period 2 (25-48  weeks). With electrical stimulation turned off, HbA1c returned toward baseline values (8.06 compared to 8.32%; 64.2 to 67.4  mmol/mol, P  =  0.465). In contrast, turning the electrical stimulation on in period 2 sustained the decrease in @entity3 c from baseline (-0.93%, -10.1mmol/mol, P  =  0.001) observed in period 1. The results indicate that implantation of the DIAMOND device causes a transient improvement in HbA1c which is not sustained beyond 24  weeks. Meal-mediated electrical stimulation accounts for the significant improvement in @entity3 c beyond 24  weeks.

title: Gastric electrical stimulation treatment of XXXX 2 @entity1 : effects of implantation versus meal-mediated stimulation. A randomized blinded cross-over trial.

answer: @entity2


abstract: Gastric electrical stimulation with the implanted DIAMOND device has been shown to improve glycemic control and decrease weight and systolic blood pressure in @entity0 with @entity2 2 @entity1 inadequately controlled with oral antidiabetic agents. The objective of this study was to determine if device implantation alone (placebo effect) contributes to the long-term metabolic benefits of DIAMOND(  ) meal-mediated gastric electrical stimulation in @entity0 with @entity2 2 @entity1 . The study was a 48  week randomized, blinded, cross-over trial in university centers comparing glycemic improvement of DIAMOND(  ) implanted @entity0 with @entity2 2 @entity1 with no activation of the electrical stimulation (placebo) versus meal-mediated activation of the electrical signal. The endpoint was improvement in glycemic control (HbA1c) from baseline to 24 and 48  weeks. In period 1 (0-24  weeks), equal improvement in HbA1c occurred independent of whether the meal-mediated electrical stimulation was turned on or left off (HbA1c -0.80% and -0.85% [-8.8 and -9.0  mmol/mol]). The device placebo improvement proved to be transient as it was lost in period 2 (25-48  weeks). With electrical stimulation turned off, HbA1c returned toward baseline values (8.06 compared to 8.32%; 64.2 to 67.4  mmol/mol, P  =  0.465). In contrast, turning the electrical stimulation on in period 2 sustained the decrease in @entity3 c from baseline (-0.93%, -10.1mmol/mol, P  =  0.001) observed in period 1. The results indicate that implantation of the DIAMOND device causes a transient improvement in HbA1c which is not sustained beyond 24  weeks. Meal-mediated electrical stimulation accounts for the significant improvement in @entity3 c beyond 24  weeks.

title: Gastric electrical stimulation treatment of @entity2 2 XXXX : effects of implantation versus meal-mediated stimulation. A randomized blinded cross-over trial.

answer: @entity1


abstract: INTRODUCTION: The aim of this study was to evaluate the effectiveness of @entity4 ( @entity4 ) management with allergoids in @entity0 with @entity1 by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. METHODS: The study population included 43 @entity0 (24 males) of 6-14 years of age, who had @entity1 and were sensitized to mites. Twenty-three individuals were treated with subcutaneous @entity4 (PURETHAL   Mites, HAL Allergy) for 8 months, i.e. the @entity4 group, and 20 were given medication to treat symptoms only, i.e. the control group. Before treatment and after 4 and 8 months, several clinical parameters, the levels of exhaled @entity3 and the pH of exhaled breath condensate (EBC) were determined. RESULTS: The @entity4 group presented with an improvement in @entity2 classification, a reduction in maintenance drug therapy and improved scores on the quality-of-life questionnaire. These changes were not observed in the control group. Both groups presented significant decreases in EBC pH values at 4 and 8 months after treatment compared to at baseline. However, analysis of the variable 'ratio' showed an increase in the EBC pH values after 8 months of treatment in the @entity4 group compared with the values at 4 months. CONCLUSIONS: @entity4 with standardized mite extract reduces @entity2 symptoms in @entity0 . A decrease in EBC pH values was observed in both groups, although the @entity4 group presented a tendency of recovered values after 8 months. Future studies of EBC pH monitoring in the longer term are needed to determine the effectiveness of this marker.    2014 S. Karger AG, Basel.

title: Assessing the efficacy of immunotherapy with a glutaraldehyde-modified house dust mite extract in XXXX by monitoring changes in clinical parameters and inflammatory markers in exhaled breath.

answer: @entity0


abstract: UNASSIGNED: The disposition of @entity0 ( @entity1 ) and metabolites in hair remains poorly characterized. We present a case involving a pharmacist in an impaired professionals' monitoring program in whom hair testing yielded @entity1 on two occasions. On both occasions, his hair was negative for the @entity2 (OM) metabolite at the cutoff concentration of 100 pg/mg. He claimed that, absent the detection of metabolite, the @entity1 necessarily represented external contamination. This prompted a review of the laboratory's @entity1 -positive hair results for the quarter April-June 2014. Overall, 466 specimens contained @entity1 , with a mean (median) concentration of 2,375 (1,060) pg/mg. Of these @entity1 -positive specimens, only 47 (10%) contained detectable OM. When @entity1 was present at or below the mean (median) concentration, only 2.2% (1.3%) of specimens were OM-positive. In the setting of @entity1 administration, the detection of OM in hair is unlikely at a cutoff concentration of 100 pg/mg. More consistent demonstration of @entity1 metabolite(s) in hair will require the validation of methods to detect OM at lower concentrations and/or methods to detect @entity3 .

title: The Disposition of XXXX and Metabolite in Human Hair.

answer: @entity0


abstract: INTRODUCTION: 15-30% of @entity0 with lung cancer will have supraclavicular and cervical lymphadenopathy (SCLN). Ultrasound (US)-guided fine-needle aspiration (FNA) cytology is regarded as an effective diagnostic tool in small size lymph nodes (LNs) and impalpable positron emission tomography detected nodes. We evaluated our diagnostic service performance in relation to the adequacy of samples for @entity1 ( @entity1 ) mutation. METHODS: Retrospective data analysis from electronic records, searching for all suspected lung cancer referrals that underwent US of the neck  FNA, over a continuous period of 4   years. RESULTS: Of 306 cases with suspected lung cancer referred to our department for US FNA of SCLN, 228 @entity0 underwent the procedure. Of the remaining 78 @entity0 , LNs were not detected in 52 cases and appeared benign in 26. Cytological diagnosis was established in 171 @entity0 (75%) for treatment decisions without further investigations. The remaining 57 @entity0 had further investigations; 45 reconfirmed the US-guided FNA diagnosis. The average LN size was 12.9   mm, and positive cytology was obtained in LNs ranging from 3 to 45   mm. Of 57 adenocarcinoma cases, 34 were tested for @entity1 confirming 4 positive, 25 negative and 5 insufficient samples. No complications were recorded. CONCLUSIONS: US-guided FNA of SCLN remains an important diagnostic tool in lung cancer. Adequate tissue can be obtained for reliable diagnosis from LNs and for @entity1 mutational analysis, without the need for more invasive and expensive investigations in more than 80% of cases.

title: Reliable XXXX mutation testing in ultrasound-guided supraclavicular lymph node fine-needle aspirates: a cohort study with diagnostic performance analysis.

answer: @entity1


abstract: We studied the bronchial arterial blood flow (Qbr) and bronchial vascular resistance (BVR) in @entity1 prepared with carotid-bronchial artery shunt. Nine adult @entity1 were anesthetized, and through a left thoracotomy a heparinized Teflon-tipped Silastic catheter was introduced into the bronchial artery. The other end of the catheter was brought out through the chest wall and through a neck incision was introduced into the carotid artery. A reservoir filled with warm heparinized blood was connected to this shunt. The height of blood column in the reservoir was kept constant at 150 cm by adding more blood. Qbr was measured, after interrupting the carotid-bronchial artery flow, by the changes in the reservoir volume. The bronchial arterial back pressure (Pbr) was measured through the shunt when both carotid-bronchial artery and reservoir Qbr had been temporarily interrupted. The mean Qbr was 34.1 +/- 2.9 (SE) ml/min, Pbr = 17.5 +/- 3.3 cm @entity2 , BVR = 3.9 +/- 0.5 cm @entity2 X ml-1 X min, mean pulmonary arterial pressure = 21.5 +/- 3.6 cm @entity2 , and pulmonary capillary wedge pressure (Ppcw) = 14.3 +/- 3.7 cm @entity2 . We further studied the effect of increased left atrial pressure on these parameters by inflating a balloon in the left atrium. The left @entity0 increased Ppcw to 25.3 +/- 3.1 cm @entity2 , Qbr decreased to 21.8 +/- 2.4 ml/min (P less than 0.05), and BVR increased to 5.5 +/- 1.0 cm @entity2 .ml-1.min (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Measurement of bronchial arterial blood flow and bronchovascular resistance in XXXX .

answer: @entity1


abstract: KEY MESSAGE: With @entity5 , the role of @entity3 is compensated by increased glycolipid content in thylakoid membrane biogenesis but not photosynthetic electron transport in @entity1 chloroplasts. In plants and cyanobacteria, anionic @entity3 (PG) is the only major phospholipid in thylakoid membranes, where neutral galactolipids @entity4 ( @entity6 ) and @entity8 ( @entity9 ) are predominant. In addition to provide a lipid bilayer matrix, PG plays a specific role in photosynthetic electron transport. Non-phosphorous sulfoquinovosyldiacylglycerol (SQDG) is another anionic lipid in thylakoids; it substitutes for PG under @entity2 (Pi) deficiency to maintain proper balance of anionic charge in thylakoid membranes. Although the crucial role of PG in photosynthesis has been deeply analyzed in cyanobacteria, its physiological function in seed plants other than photosynthesis remains unclear. To reveal specific roles of PG and functional overlaps with other thylakoid lipids, we characterized a @entity0 @entity1 mutant ( @entity7 -2) under Pi-controlled conditions. Under Pi-sufficient conditions, the proportion of PG and other thylakoid lipids was decreased in @entity7 -2, which led to severe disruption of thylakoid membrane biogenesis. Under Pi-deficient conditions, the proportion of all glycolipids in the mutant was greatly increased, with that of PG further decreased. In Pi-deficient @entity7 -2, thylakoid membranes remarkably developed, which was accompanied by a change in nucleoid morphology and restored expression of nuclear- and plastid-encoded photosynthesis genes. Increase in glycolipid content with @entity0 may compensate for the loss of PG in terms of thylakoid membrane biogenesis. Although @entity0 increased chlorophyll and photosynthesis protein content in @entity7 -2, it critically decreased photochemical activity in PSII. Further deprivation of PG in photosynthesis complexes may abolish the PSII activity in Pi-deficient @entity7 -2, which suggests that glycolipids cannot replace PG in photosynthesis.

title: Specific role of XXXX and functional overlaps with other thylakoid lipids in @entity1 chloroplast biogenesis.

answer: @entity3


abstract: KEY MESSAGE: With @entity5 , the role of @entity3 is compensated by increased glycolipid content in thylakoid membrane biogenesis but not photosynthetic electron transport in @entity1 chloroplasts. In plants and cyanobacteria, anionic @entity3 (PG) is the only major phospholipid in thylakoid membranes, where neutral galactolipids @entity4 ( @entity6 ) and @entity8 ( @entity9 ) are predominant. In addition to provide a lipid bilayer matrix, PG plays a specific role in photosynthetic electron transport. Non-phosphorous sulfoquinovosyldiacylglycerol (SQDG) is another anionic lipid in thylakoids; it substitutes for PG under @entity2 (Pi) deficiency to maintain proper balance of anionic charge in thylakoid membranes. Although the crucial role of PG in photosynthesis has been deeply analyzed in cyanobacteria, its physiological function in seed plants other than photosynthesis remains unclear. To reveal specific roles of PG and functional overlaps with other thylakoid lipids, we characterized a @entity0 @entity1 mutant ( @entity7 -2) under Pi-controlled conditions. Under Pi-sufficient conditions, the proportion of PG and other thylakoid lipids was decreased in @entity7 -2, which led to severe disruption of thylakoid membrane biogenesis. Under Pi-deficient conditions, the proportion of all glycolipids in the mutant was greatly increased, with that of PG further decreased. In Pi-deficient @entity7 -2, thylakoid membranes remarkably developed, which was accompanied by a change in nucleoid morphology and restored expression of nuclear- and plastid-encoded photosynthesis genes. Increase in glycolipid content with @entity0 may compensate for the loss of PG in terms of thylakoid membrane biogenesis. Although @entity0 increased chlorophyll and photosynthesis protein content in @entity7 -2, it critically decreased photochemical activity in PSII. Further deprivation of PG in photosynthesis complexes may abolish the PSII activity in Pi-deficient @entity7 -2, which suggests that glycolipids cannot replace PG in photosynthesis.

title: Specific role of @entity3 and functional overlaps with other thylakoid lipids in XXXX chloroplast biogenesis.

answer: @entity1


abstract: Regulation of macrophage @entity4 plays an important role in pathogenesis of @entity0 . However, the precise involvement of any parasite molecule in this process remains uncertain. In the current study, in silico wide analysis demonstrated that genes in the @entity2 genome are highly enriched for CpG motifs, with sequence frequency of 8.7%. Here, we show that unmethylated species-specific CpG motifs in LdDNA significantly (P = 0.01) delay macrophage @entity4 by endosomal interaction with TLR9 via the adaptor protein MyD88. Importantly, LdDNA triggered high levels of luciferase activity (P = 0.001) under NF-kB-dependent transcription in HEK-TLR9 cells. Furthermore, the activation of caspases in macrophages was inhibited (P = 0.001) in the presence of LdDNA. Notably, the delay of @entity4 was mediated by modulation of the antiapoptotic proteins, Mcl-1 and Bfl-1, and impairment of loss of     m in macrophages through the neutralization of oxidative and nitrosative stress. The inhibition of caspase activation and up-regulation of Mcl-1 by LdDNA were TLR9 dependent. Analysis of the targets of LdDNA identified an early activation of the TLR9-dependent PI3K/Akt and SFK pathways, which were required for the observation of the antiapoptotic effects in macrophages. Moreover, we demonstrate that LdDNA modulates the TLR9-IkB-a pathway by promoting the @entity1 phosphorylation of TLR9 and the TLR9-mediated recruitment of Syk kinase. The results have identified a novel, TLR9-dependent antiapoptotic function of LdDNA, which will provide new opportunities for discovering and evaluating molecular targets for drug and vaccine designing against @entity3 .

title: Unmethylated CpG motifs in the XXXX DNA regulate TLR9-dependent delay of programmed cell death in macrophages.

answer: @entity2


abstract: In the past few decades, @entity7 ( @entity7 ) has evolved from a disease that was untreatable and progressive, to one that can be easily controlled with antiviral therapy. However, @entity0 with severe @entity4 still remain difficult to treat despite the availability of highly potent nucleos(t)ide analogs. These include those with underlying @entity1 , severe flares of @entity7 ( @entity2 ), and for those undergoing liver transplantation. For those with established @entity1 , antiviral therapy should be considered for all, as unpredictable flares can still occur, which can be fatal for those with @entity4 . However, even with effective viral suppression, the development of @entity2 can still occur. For @entity0 with severe flares of @entity7 , although the use of antiviral can improve long term outcomes, a significant proportion may still die without liver transplantation. The short term prognosis of these @entity0 is dependent on both the severity of flare and underlying pre-existing @entity4 . In @entity0 with decompensated @entity1 , @entity5 secondary to severe flares, or those with @entity2 , liver transplantation may be curative. After liver transplantation, long term antiviral therapy is required to prevent @entity3 from recurrent @entity6 . The use of @entity6 immune globulin (HBIG) in combination with an oral antiviral agent has been the mainstay of post-transplant antiviral regimen for over a decade. With newer and more potent antiviral agents such as @entity8 and @entity9 , use of these agents along with HBIG have demonstrated to be effective in preventing significant recurrence in the long term.

title: Management of @entity7 in severe XXXX .

answer: @entity4


abstract: In the past few decades, @entity7 ( @entity7 ) has evolved from a disease that was untreatable and progressive, to one that can be easily controlled with antiviral therapy. However, @entity0 with severe @entity4 still remain difficult to treat despite the availability of highly potent nucleos(t)ide analogs. These include those with underlying @entity1 , severe flares of @entity7 ( @entity2 ), and for those undergoing liver transplantation. For those with established @entity1 , antiviral therapy should be considered for all, as unpredictable flares can still occur, which can be fatal for those with @entity4 . However, even with effective viral suppression, the development of @entity2 can still occur. For @entity0 with severe flares of @entity7 , although the use of antiviral can improve long term outcomes, a significant proportion may still die without liver transplantation. The short term prognosis of these @entity0 is dependent on both the severity of flare and underlying pre-existing @entity4 . In @entity0 with decompensated @entity1 , @entity5 secondary to severe flares, or those with @entity2 , liver transplantation may be curative. After liver transplantation, long term antiviral therapy is required to prevent @entity3 from recurrent @entity6 . The use of @entity6 immune globulin (HBIG) in combination with an oral antiviral agent has been the mainstay of post-transplant antiviral regimen for over a decade. With newer and more potent antiviral agents such as @entity8 and @entity9 , use of these agents along with HBIG have demonstrated to be effective in preventing significant recurrence in the long term.

title: Management of XXXX in severe @entity4 .

answer: @entity7


abstract: Five cases of @entity4 occurring in chronic alcoholics are described. The clinical diagnosis was based on the presence of @entity3 , low dietary intake of @entity10 and the therapeutic response to oral @entity10 . Complicating @entity4 was excluded by haemodynamic studies, left ventriculography; coronary angiography and endomyocardial biopsy. Haemodynamic measurements including quantitative left ventriculography are reported. They indicate that left ventricular function is depressed despite elevated cardiac output. Biopsy material was studied by light and electron microscopy. No lesion specific to beriberi was detected by either technique although the biopsies were quantitatively abnormal. The histological changes resemble those in early reports based on necropsy material, and consist of vacuolation and intercellular @entity1 in the early stages with myofibre @entity7 , @entity2 and cellular infiltration in the chronic cases. The @entity11 test and response to intravenous @entity10 during catheter studies are valuable diagnostic tests. Plasma @entity6 , @entity9 and @entity8 levels were lower than in @entity0 with low output @entity5 . The incidence of @entity4 appears to be greater than is generally realized.

title: The haemodynamic, histopathological and hormonal features of XXXX .

answer: @entity4


abstract: PURPOSE: To assess the clinical features and surgical outcomes of 23-Gauge (G) vitrectomy for lens fragments dropped into the vitreous during @entity2 surgery. METHODS: A retrospective, non-comparative, interventional case series at a single medical center. The medical records of 45 eyes from 45 consecutive @entity0 who were referred to our hospital for surgical retrieval of phacoemulsification dropped lens fragments and who underwent 23-G vitrectomy were retrospectively reviewed. Data pertaining to @entity0 demographics, pre- and post-operative Snellen visual acuity, and @entity3 were recorded. Factors associated with dropped lens fragments were also examined. RESULTS: Mean @entity0 age was 68.18      11.47  years. The preoperative and postoperative mean logarithm of minimum angle of resolution (logMAR) visual acuity was 1.91      0.59 (Snellen equivalent 0.06      0.15) and 0.42      0.51 (Snellen equivalent 0.54      0.31), respectively. Forty-two eyes (93.3%) had dislocated lens fragments <50% of the total lens size. Two eyes (4.4%) had a large and hard lens nucleus, which necessitated the use of a 20-G fragmatome to efficiently and completely remove the lens material. At the final examination, 30 eyes (66.6%) had a visual acuity better than 20/40. Post-vitrectomy complications included elevated IOP for at least 3  months (n  =  5 eyes, 11.1%), intraocular @entity6 (n  =  2 eyes, 4.4%), and @entity4 (n  =  1 eye, 2.2%). No cases of @entity1 or @entity5 were observed. CONCLUSIONS: A 23-G vitrectomy is safe and efficient for the surgical management of dropped lens fragments following @entity2 surgery.

title: Surgical outcomes of 23-gauge vitrectomy for the management of lens fragments dropped into the vitreous cavity during XXXX surgery.

answer: @entity2


abstract: PURPOSE: Study the ophthalmic morbidities for @entity0 born prematurely at a Tertiary care center in Riyadh city. METHODS: Retrospective, longitudinal cohort study at King Fahad Medical City for premature @entity0 born at gestational age (GA)    32  weeks or birth weight (BW)    1500  g during the study period from January 1, 2007, until the end of December 2009 was conducted. Short term outcome was diagnosis with @entity3 ( @entity3 ) and long-term outcome was ophthalmic findings at age 18-24  months. RESULTS: The cumulative incidence of @entity3 was 30%. @entity0 diagnosed with @entity3 had a mean GA of 27  weeks (23-35  weeks) and mean BW of 907  g (530-1730  g). Risk factors other than GA and BW for @entity3 , identified in the predictive logistic regression model, were blood transfusion [ @entity6 ] and diagnosis with @entity1 (OR  =  2.90). Strabismus was identified in 14% of the study cohort. Diagnosis of @entity5 (spherical equivalent    +0.75  D) was equal in both @entity3 and no- @entity3 groups (p  =  0.56). @entity4 (spherical equivalent    -0.75  D) and @entity2    1.00  D were diagnosed more frequently in the @entity3 group (p  <  0.0001 and 0.04, respectively). CONCLUSIONS: A higher incidence of @entity3 was observed in this cohort compared to some Saudi Arabian centers. It is recommended that the screening criteria be maintained and that the effects of further control of blood transfusion be assessed in a prospective study. The authors recommend an extra ophthalmic evaluation at the age of 18-24  months for all premature @entity0 born with GA       32  weeks.

title: Ophthalmic short- and long-term outcomes for premature XXXX : Results of an extended follow-up program in Saudi Arabia.

answer: @entity0


abstract: UNASSIGNED: Background and study aim: Intragastric balloons are used as a treatment for @entity1 . Much of the data collected on balloons has been in the context of clinical trials in academic medical centers or as a bridge to bariatric surgery in @entity1 centers. The aim of this study was to investigate the efficacy and safety of balloon treatment in private practice. @entity0 and methods: This was a retrospective analysis of 6-month @entity2 data and balloon-related complications of @entity0 referred to three private centers for @entity1 treatment. Results: A total of 815 @entity0 (131 males) were referred for balloon treatment (mean age 36.5 years, mean body weight 111.7kg, mean body mass index [BMI] 38.1kg/m(2)). The 6-month @entity2 data were available for 672 @entity0 . Mean @entity2 was 20.9kg (7.2 BMI units). A total of 372 @entity0 visited the center only once following balloon placement (i.e. for balloon removal), but these @entity0 still achieved a mean @entity2 of 19.4kg (6.6 BMI units). Successful @entity2 (i.e. >= 10%) was achieved in 85.0%. Severe complications consisted of dehydration requiring hospital admission (n=2; 0.2%), and @entity4 caused by @entity3 , which required surgery (n=2; 0.2%). A total of 35 deflated balloons (4.3%) were passed rectally without any adverse events. Severe @entity5 following balloon placement was diagnosed in 12 @entity0 (1.5%). A total of 53 @entity0 (6.5%) requested balloon removal during the first month. Nine balloons (1.1%) were removed for medical reasons. Conclusion: In the private practice setting, intragastric balloons on their own, without an intensive lifestyle program and supportive consultations, resulted in safe and substantial weight losses, and may fill the therapeutic gap between pharmacotherapy and surgery.

title: Outcomes of XXXX in a private practice setting.

answer: @entity3


abstract: Background and study aims: Endoscopic resection is the standard treatment for superficial @entity1 . Data on early @entity2 (EAC) are widely restricted to endoscopic mucosal resection (EMR), whereas large studies have been published on endoscopic submucosal dissection (ESD) for @entity3 ( @entity3 ). ESD has potential advantages regarding en bloc and R0 resection rates, which have been demonstrated for @entity3 . However, studies have failed to confirm these advantages in EAC. The aim of this study was to investigate the efficacy of ESD in early @entity1 . @entity0 and methods: A total of 111 early @entity1 (87 EACs and 24 ESCCs) were resected by ESD at a German tertiary referral center. A total of 60 EACs were resected within Barrett's segments  <=M3. Resection rates, complications, and follow-up data were recorded prospectively. Results: En bloc resection rates were 95.4% for EAC and 100% for @entity3 (P=0.575), and R0 resection rates were 83.9% and 91.7%, respectively (P=0.515). The R0 resection rate was higher in Barrett's  <=M3 vs. >M3 (90% vs. 70.4%; P=0.029). The curative resection rate was 72.4% for EAC vs. 45.8% for @entity3 (P=0.026). Endoluminal recurrence was observed in 2.4% of EACs (8% in Barrett's >M3, 0% in Barrett's  <=M3), and 0% of ESCCs. Complications included strictures (11.7%) and bleedings (0.9%), but no perforation. Disease-specific survival was 97.7% (EAC) and 95.8% ( @entity3 ), and overall survival was 96.6% (EAC) and 66.7% ( @entity3 ) over a mean follow-up period of 24.3 months and 38.0 months, respectively. Conclusions: ESD was shown to be a safe resection method, achieving high R0 resection rates in both EAC and @entity3 . Recurrence rates were low. To improve R0 resection within long Barrett's segments, diagnosis of the lateral extension of the lesion needs to be improved.

title: Early XXXX in Europe: endoscopic treatment by endoscopic submucosal dissection.

answer: @entity1


abstract: The efficacy of @entity4 and @entity6 for treating @entity0 -induced @entity3 was determined in a conscious @entity1 model with a previous @entity2 remote from the @entity0 area. Temporary (up to 5.5 minutes) occlusion of the circumflex coronary artery was made in eight conscious @entity1 that had sustained an @entity2 13 to 35 days previously. Each @entity1 served as its own control. @entity3 were observed in 100% of control experiments but in only 25% of experiments after @entity4 pretreatment at 0.4 mg/kg body weight. Repetitive ventricular complexes, defined as two or more consecutive ventricular complexes terminating spontaneously in sinus rhythm, were seen in 88% of control experiments and 13% of @entity4 experiments, whereas @entity5 was seen in 6% of control experiments but in no @entity4 experiment. Thus, @entity4 abolished @entity3 or reduced the grade of @entity3 in all @entity1 . Six of the eight @entity1 were also tested with @entity6 pretreatment at one or two doses resulting in mean plasma levels of 3.8 +/- 2.0 micrograms/ml. @entity3 were seen in 92% of control experiments and 100% of @entity6 experiments. The incidence of @entity5 increased from 8% in control to 60% in @entity6 experiments. It is concluded that @entity4 may prevent severe @entity0 -induced @entity3 after a recent @entity2 , whereas @entity6 may in some cases aggravate @entity3 .

title: Effects of @entity4 and XXXX in a @entity1 model of sudden coronary death.

answer: @entity6


abstract: The efficacy of @entity4 and @entity6 for treating @entity0 -induced @entity3 was determined in a conscious @entity1 model with a previous @entity2 remote from the @entity0 area. Temporary (up to 5.5 minutes) occlusion of the circumflex coronary artery was made in eight conscious @entity1 that had sustained an @entity2 13 to 35 days previously. Each @entity1 served as its own control. @entity3 were observed in 100% of control experiments but in only 25% of experiments after @entity4 pretreatment at 0.4 mg/kg body weight. Repetitive ventricular complexes, defined as two or more consecutive ventricular complexes terminating spontaneously in sinus rhythm, were seen in 88% of control experiments and 13% of @entity4 experiments, whereas @entity5 was seen in 6% of control experiments but in no @entity4 experiment. Thus, @entity4 abolished @entity3 or reduced the grade of @entity3 in all @entity1 . Six of the eight @entity1 were also tested with @entity6 pretreatment at one or two doses resulting in mean plasma levels of 3.8 +/- 2.0 micrograms/ml. @entity3 were seen in 92% of control experiments and 100% of @entity6 experiments. The incidence of @entity5 increased from 8% in control to 60% in @entity6 experiments. It is concluded that @entity4 may prevent severe @entity0 -induced @entity3 after a recent @entity2 , whereas @entity6 may in some cases aggravate @entity3 .

title: Effects of XXXX and @entity6 in a @entity1 model of sudden coronary death.

answer: @entity4


abstract: The efficacy of @entity4 and @entity6 for treating @entity0 -induced @entity3 was determined in a conscious @entity1 model with a previous @entity2 remote from the @entity0 area. Temporary (up to 5.5 minutes) occlusion of the circumflex coronary artery was made in eight conscious @entity1 that had sustained an @entity2 13 to 35 days previously. Each @entity1 served as its own control. @entity3 were observed in 100% of control experiments but in only 25% of experiments after @entity4 pretreatment at 0.4 mg/kg body weight. Repetitive ventricular complexes, defined as two or more consecutive ventricular complexes terminating spontaneously in sinus rhythm, were seen in 88% of control experiments and 13% of @entity4 experiments, whereas @entity5 was seen in 6% of control experiments but in no @entity4 experiment. Thus, @entity4 abolished @entity3 or reduced the grade of @entity3 in all @entity1 . Six of the eight @entity1 were also tested with @entity6 pretreatment at one or two doses resulting in mean plasma levels of 3.8 +/- 2.0 micrograms/ml. @entity3 were seen in 92% of control experiments and 100% of @entity6 experiments. The incidence of @entity5 increased from 8% in control to 60% in @entity6 experiments. It is concluded that @entity4 may prevent severe @entity0 -induced @entity3 after a recent @entity2 , whereas @entity6 may in some cases aggravate @entity3 .

title: Effects of @entity4 and @entity6 in a XXXX model of sudden coronary death.

answer: @entity1


abstract: Recruitment of basophils to sites of homocytotropic antibody-mediated @entity1 has been well documented in both experimental and clinical situations. Mechanisms underlying tissue basophil accumulation, however, remain unclear and may involve @entity6 , cell proliferation, or both. We have recently reported the presence in @entity0 blood of circulating basophil/mast cell progenitors on the basis of @entity3 content of granulocyte colonies grown in methylcellulose. In the current studies we have analyzed the peripheral blood of 30 @entity0 with @entity4 and 25 comparable control subjects for frequency of basophil/mast cell progenitors by analysis of the @entity3 content of individual granulocyte colonies. Forty percent of granulocyte colonies in cultures of @entity5 @entity0 contained @entity3 in comparison to only 11% in cultures of control subjects (p less than 0.001). @entity3 content per colony as well as mean @entity3 per cell in each colony was higher in granulocyte colonies of @entity5 subjects and could not be related to colony size or culture conditions. Granulocyte colony growth was enhanced by antigen-stimulated, peripheral blood lymphomononuclear cell--conditioned media of @entity5 @entity0 . @entity3 -positive colonies were found more frequently in active versus quiescent @entity2 (p less than 0.05). These results are consistent with the hypothesis that basophils accumulate at sites of @entity1 at least in part by recruitment of progenitors from circulation and subsequent differentiation in situ in response to lymphokines. Further studies by use of hemopoietic assays could elucidate the contribution of basophil production to the development of @entity1 .

title: Increased numbers of circulating basophil progenitors in XXXX @entity0 .

answer: @entity5


abstract: Recruitment of basophils to sites of homocytotropic antibody-mediated @entity1 has been well documented in both experimental and clinical situations. Mechanisms underlying tissue basophil accumulation, however, remain unclear and may involve @entity6 , cell proliferation, or both. We have recently reported the presence in @entity0 blood of circulating basophil/mast cell progenitors on the basis of @entity3 content of granulocyte colonies grown in methylcellulose. In the current studies we have analyzed the peripheral blood of 30 @entity0 with @entity4 and 25 comparable control subjects for frequency of basophil/mast cell progenitors by analysis of the @entity3 content of individual granulocyte colonies. Forty percent of granulocyte colonies in cultures of @entity5 @entity0 contained @entity3 in comparison to only 11% in cultures of control subjects (p less than 0.001). @entity3 content per colony as well as mean @entity3 per cell in each colony was higher in granulocyte colonies of @entity5 subjects and could not be related to colony size or culture conditions. Granulocyte colony growth was enhanced by antigen-stimulated, peripheral blood lymphomononuclear cell--conditioned media of @entity5 @entity0 . @entity3 -positive colonies were found more frequently in active versus quiescent @entity2 (p less than 0.05). These results are consistent with the hypothesis that basophils accumulate at sites of @entity1 at least in part by recruitment of progenitors from circulation and subsequent differentiation in situ in response to lymphokines. Further studies by use of hemopoietic assays could elucidate the contribution of basophil production to the development of @entity1 .

title: Increased numbers of circulating basophil progenitors in @entity5 XXXX .

answer: @entity0


abstract: OBJECTIVE: To establish stable and controllable @entity6 with accurate degree and good repeatability in @entity1 model. METHODS: Controlled cortical impact (CCI) device was used to prepare for the @entity1 @entity6 model by the impact head of different model (Group A No. 4, Group B No. 5, Group C No. 6) and the impact depth (Group A: 1.5-2.0 mm, Group B: 2.5-3.0 mm, Group C: 3.5-4.0 mm) with impact time of 0.1 s and impact velocity of 2.5 m/s. Twelve @entity1 with three months of age were used in each group (the impact depth of every two @entity1 was added 1 mm respectively). After modeling for 1 h, magnetic resonance imaging (MRI) was received and brain histopathology was observed to assess degree of @entity2 of three groups. RESULTS: After modeling of Group A, MRI showed that the cortex structure was damaged with a small amount of @entity4 in center and mild @entity0 around, and the total volume of injury was (28.69  4.94) mm(3). Pathology revealed the injury was confined to the superficial cortical with mild @entity0 of nerve cell, which was assessed as mild @entity3 . While after modeling, MRI of Group B showed that the structure of cortex and medulla were damaged simultaneously and extended to cerebral nuclei zone, with 4 cases of @entity5 in the center and larger @entity0 range around, and the total volume of injury was (78.38  9.28) mm(3). Pathology revealed the injury range was reached nuclei zone, with swell of nerve cell and mitochondria, which was assessed to moderate @entity3 . After modeling of Group C, MRI showed that extensive tissue injury was appeared in cortex and medulla and deep nuclei, with 9 cases of @entity5 and large @entity0 signal of surrounding tissue T2WI, while in 5 cases, lateral nucleus of injury signal was increased, and the total volume of injury was (135.89  24.80) mm(3). Pathology revealed the deep cerebral nuclei was damaged, with the disappearance of neuronal structure and vacuolization of mitochondria, which was assessed as severe @entity3 . MRI changes were consistent with pathological changes in three groups of model, and the injury range was significantly different (P<0.01). CONCLUSIONS: Application of CCI can make stable quantitative @entity3 model, which overcomes the randomness in @entity2 model and possesses highly unity in iconography and pathology changes. This can provide quantitative modeling reference for clinical research.

title: Assessment of XXXX degree in animal model.

answer: @entity3


abstract: BACKGROUND: Self-collected @entity3 ) testing could reduce barriers to @entity1 screening, with performance comparable to clinician-collected specimens. The ability of self-collected specimens to cross-sectionally and prospectively detect precursor lesions was investigated in an HPV vaccine randomized trial in Costa Rica. METHODS: In the trial, 7466 @entity0 age 18 to 25 years received an @entity4 /18 or control vaccine and were followed at least annually for four years. In this secondary analysis, we included all @entity0 who provided a self-collected cervicovaginal specimen six months after enrollment (5109 @entity0 = full analytical cohort). A subset (615 @entity0 = restricted cohort) also had clinician-collected specimens at the six-month postenrollment visit. High-grade squamous @entity2 or repeat low-grade squamous @entity2 prompted colposcopic referral throughout the study. HPV testing was performed with SPF10PCR/DEIA/LiPA25. Cross-sectional and prospective sensitivity, specificity, and predictive values were estimated. RESULTS: In the full cohort, one-time HPV testing on self-collected samples detected prevalent CIN2+ with a sensitivity of 88.7% (95% confidence interval [CI] =77.0% to 95.7%) and a specificity of 68.9% (95% CI = 67.6% to 70.1%). For predicting incident CIN2+ in the subsequent four years, sensitivity was 73.9% (95% CI = 65.8% to 81.0%) and specificity 69.4% (95% CI = 68.1% to 70.7%). In the restricted cohort, for incident CIN2+, self-collected HPV was much more sensitive than cytology (80.0% vs 10.0%); relative sensitivity was 0.1 (95% CI = 0.03% to 0.5%). Furthermore, three times more @entity0 with normal baseline cytology developed incident CIN2+ than those with negative self-collected HPV. Self-collected and clinician-collected HPV testing had comparable performance. Agreement between self- and clinician-collected samples was 89.7% (kappa = 0.78, McNemar   2 = 0.62) for carcinogenic HPV types. CONCLUSIONS: Self-collected specimens can be used for HPV-based screening, providing sensitivity and specificity comparable with clinician-collected specimens and detecting disease earlier than cytology.

title: Performance of self-collected cervical samples in screening for future precancer using XXXX DNA testing.

answer: @entity3


abstract: OBJECTIVE: To evaluate the nutritional status of schoolchildren, resident in a semiarid region in the Northeastern Brazil. METHODS: This is a cross-sectional study, involving 860 @entity0 and adolescents aged from 5-19 years-old, enrolled in three public schools in the county. The selection of schools was non-probabilistic type and unintentional. The initial population, which integrated the database, was composed by 1,035 @entity0 and teenagers, and 175 students (16.9%) were excluded because of inconsistency in the anthropometric data, resulting in a sample of 860 students. The following outcomes were considered: stunting ( @entity2 ), @entity1 (overweight), being the height/age and body mass index/age (BMI/Age), indices respectively used. @entity0 and adolescents with height <-2 standard deviations and overweight and obese weight z score >= 1 were considered stunted. The statistical analysis was descriptive. RESULTS: The prevalence of stunting and overweight/ @entity1 was 9.1% and 24.0%, respectively. Overweight and stunting were higher in adolescents aged 15 and over, compared to other age groups analyzed. In relation to gender, @entity2 presented itself in a similar way, but overweight was more frequent among females. CONCLUSIONS: The results revealed that excess weight, here represented by the sum of @entity1 , was more prevalent than stunting ( @entity2 ), highlighting the urgent need for attention to this problem in order to design interventions capable of contributing to the improvement of schoolchildren nutritional status.

title: [Nutritional status of XXXX and adolescents from a town in the semiarid Northeastern Brazil].

answer: @entity0


abstract: BACKGROUND AND AIMS: To assess the efficacy and tolerability of adjunctive pharmacotherapy for smoking cessation in adults with @entity6 ( @entity6 ) by means of a systematic review and network meta-analysis. METHOD: We searched Embase, Medline, PsychINFO and the Cochrane Central Register of Controlled Trials from database inception to 1 December 2014 for randomized controlled trials (RCTs) published in English. We included all studies of smokers with @entity6 (including @entity1 , @entity5 , @entity2 , @entity9 and @entity3 ) who were motivated to quit smoking. Pharmacotherapies included @entity7 replacement therapy (NRT), @entity4 and @entity8 delivered as monotherapy or in combination compared with each other or placebo. The efficacy outcome was self-reported sustained smoking cessation, verified biochemically at the longest reported time-point. The tolerability outcome was number of @entity0 discontinuing the trial due to any adverse event. RESULTS: Seventeen study reports were included, which represented 14  individual RCTs. No trials were found in @entity0 with @entity3 , @entity9 or that compared NRT monotherapy with placebo. A total of 356 and 423 @entity0 were included in the efficacy and tolerability analyses, respectively. From the network meta-analysis, both @entity4 and @entity8 were more effective than placebo [odds ratio (OR)  =  4.51, 95% @entity10 .45-14.04 and OR  =  5.17, 95% @entity10 .78-15.06, respectively]. Data were insensitive to an assessment of @entity8 versus @entity4 (OR  =  1.15, 95% CrI  =  0.24-5.45). There were no significant differences in tolerability. All outcomes were rated by GRADE criteria as very low quality. CONCLUSIONS: The limited evidence available to date suggests that @entity4 and @entity8 are effective and tolerable for smoking cessation in adults with serious mental illnesses.

title: Efficacy and tolerability of pharmacotherapy for smoking cessation in adults with XXXX : a systematic review and network meta-analysis.

answer: @entity6


abstract: It is increasingly common to monitor the marine environment and establish geographic trends of environmental contamination by measuring contaminant levels in animals from higher trophic levels. The health of an ecosystem is largely reflected in the health of its inhabitants. As an apex predator, the common bottlenose dolphin ( @entity4 ) can reflect the health of near shore marine ecosystems, and reflect coastal threats that pose risk to @entity0 health, such as legacy contaminants or marine toxins, e.g. @entity2 ( @entity2 ) and brevetoxins. Major advances in the understanding of dolphin biology and the unique adaptations of these animals in response to the marine environment are being made as a result of the development of cell-lines for use in in vitro experiments, the production of monoclonal antibodies to recognize dolphin proteins, the development of dolphin DNA microarrays to measure global gene expression and the sequencing of the dolphin genome. These advances may play a central role in understanding the complex and specialized biology of the dolphin with regard to how this species responds to an array of environmental insults. This work presents the creation, characterization and application of a new molecular tool to better understand the complex and unique biology of the common bottlenose dolphin and its response to environmental stress and @entity1 . A dolphin oligo microarray representing 24,418 unigene sequences was developed and used to analyze blood samples collected from 69 dolphins during capture-release health assessments at five geographic locations (Beaufort, NC, Sarasota Bay, FL, Saint Joseph Bay, FL, Sapelo Island, GA and Brunswick, GA). The microarray was validated and tested for its ability to: 1) distinguish male from female dolphins; 2) differentiate dolphins inhabiting different geographic locations (Atlantic coasts vs the Gulf of Mexico); and 3) study in detail dolphins resident in one site, the Georgia coast, known to be heavily contaminated by @entity5 , an uncommon polychlorinated ( @entity3 ) mixture. The microarray was able to distinguish dolphins by sex, geographic location, and corroborate previously published health irregularities for the Georgia dolphins. Genes involved in xenobiotic metabolism, development/differentiation and oncogenic pathways were found to be differentially expressed in GA dolphins. The report bridges the advancements in dolphin genome sequencing to the first step towards providing a cost-effective means to screen for indicators of chemical toxin exposure as well as disease status in top level predators.

title: Microarray applications to understand the impact of exposure to environmental contaminants in wild dolphins ( XXXX ).

answer: @entity4


abstract: AIMS: Although considerable attention has been paid to the concept of mentalization in psychotherapy, there is little research on mentalization as predictor of psychotherapy process and outcome. Using data from a randomized controlled trial of cognitive-behavioral therapy and interpersonal psychotherapy for @entity2 , we studied mentalization in 85 outpatients with @entity2 ( @entity2 ) according to the Diagnostic and Statistical Manual of @entity1 . It was hypothesized that @entity0 showing lower capacity for mentalization would experience poorer quality of alliance and worse outcome. METHOD: Depressive symptoms were measured each session using the Beck Depression Inventory-II. Mentalization was measured as reflective functioning (RF) on a slightly shortened version of the Adult Attachment Interview. A measure of @entity2 -specific reflective functioning (DSRF), measuring mentalization about depressive symptoms, was also used. The Working Alliance Inventory-Short Form Revised was completed after each session by both therapist and @entity0 . Longitudinal multilevel modeling was used to analyze data. RESULTS: The @entity0 had on average very low RF (M = 2.62, SD = 1.22). Lower pretreatment RF/DSRF predicted significantly lower therapist-rated working alliance during treatment. RF did not affect @entity0 -rated alliance, but lower DSRF predicted lower @entity0 -rated alliance across treatment. @entity0 with higher RF/DSRF had better outcomes on self-rated @entity2 . CONCLUSIONS: The findings showed lower than normal capacity for mentalization in @entity0 with @entity2 . Lower RF/DSRF predicted worse treatment outcome. More research is needed to understand how RF affects psychotherapy response and how RF is affected after recovery from @entity2 . (PsycINFO Database Record

title: Reflective functioning as predictor of working alliance and outcome in the treatment of XXXX .

answer: @entity2


abstract: BACKGROUND AND AIMS: Interventions for lifestyle diseases including @entity2 ( @entity2 ) have focused on overweight and @entity1 populations. The impact of adult weight gain on @entity2 development among normal weight individuals remains unclear. METHODS: In this cross-sectional study, we collected data from @entity0 presenting to a health check-up program. Ultrasound-diagnosed @entity2 prevalence was examined over 1-kg increments of weight change since age 20. Relative risks (RR) were calculated in @entity0 and @entity0 stratified by current weight (normal, overweight, and @entity1 ). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusting for potential confounders. RESULTS: Among 21,496 @entity0 , 3,498 cases of @entity2 (16.3%) were observed. Prevalence of @entity2 increased with weight gain since age 20; among the 10.1-11.0 kg weight gain group, 41.6% of @entity0 and 24.8% of @entity0 had @entity2 . Multivariate analysis by quartiles showed that weight change was significantly associated with @entity2 risk in @entity0 and @entity0 . Risk of @entity2 associated with weight change (10-kg increments) was significantly higher in normal weight individuals ( @entity0 : OR 7.53, 95% CI 4.99-11.36, @entity0 : OR 12.20, 95% CI 7.45-19.98) than overweight ( @entity0 : OR 1.61, 95% CI 0.91-2.85, @entity0 : OR 2.90, 95% CI 0.99-8.54) and @entity1 ( @entity0 : OR 4.0, 95% CI 2.97-5.39, @entity0 : OR 2.68, 95% CI; 2.00-3.60). CONCLUSIONS: @entity2 is robustly associated with weight change since age 20. This effect appears particularly strong in individuals at normal weight, suggesting an important role for early and longitudinal weight monitoring, even among healthy individuals at normal weight.

title: Weight gain since age 20 is associated with XXXX in normal weight individuals.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Rates and extent of recovery after @entity1 vary considerably between individuals and genetic factors are thought to contribute to post- @entity1 outcome. @entity3 ( @entity3 ) plays important roles in brain plasticity and repair and has been shown to be involved in @entity1 severity, recovery, and outcome in animal models. Few clinical studies on @entity3 genotypes in relation to @entity2 have been performed. The aims of the present study are therefore to investigate whether genetic variation at the @entity3 locus is associated with @entity1 , recovery and/or short-term and long-term functional outcome after @entity2 . METHODS: Four @entity3 tagSNPs were analyzed in the Sahlgrenska Academy Study on @entity2 (SAHLSIS; 600 @entity0 and 600 controls, all aged 18-70 years). @entity1 severity was assessed using the NIH @entity1 Scale (NIHSS). @entity1 recovery was defined as the change in NIHSS over a 3-month period. Short- and long-term functional outcome post- @entity1 was assessed using the modified Rankin Scale at 3 months and at 2 and 7 years after @entity1 , respectively. RESULTS: No SNP was associated with @entity1 severity or recovery at 3 months and no SNP had an impact on short-term outcome. However, @entity4 was independently associated with poor functional outcome 7-years after @entity1 (OR 0.66, 95% CI 0.46-0.92; P= 0.006). CONCLUSIONS: @entity3 gene variants were not major contributors to @entity2 severity, recovery, or short-term functional outcome. However, this study suggests that variants in the @entity3 gene may contribute to poor long-term functional outcome after @entity2 .

title: Genetic variation at the @entity3 locus: evidence for association with long-term outcome after XXXX .

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Rates and extent of recovery after @entity1 vary considerably between individuals and genetic factors are thought to contribute to post- @entity1 outcome. @entity3 ( @entity3 ) plays important roles in brain plasticity and repair and has been shown to be involved in @entity1 severity, recovery, and outcome in animal models. Few clinical studies on @entity3 genotypes in relation to @entity2 have been performed. The aims of the present study are therefore to investigate whether genetic variation at the @entity3 locus is associated with @entity1 , recovery and/or short-term and long-term functional outcome after @entity2 . METHODS: Four @entity3 tagSNPs were analyzed in the Sahlgrenska Academy Study on @entity2 (SAHLSIS; 600 @entity0 and 600 controls, all aged 18-70 years). @entity1 severity was assessed using the NIH @entity1 Scale (NIHSS). @entity1 recovery was defined as the change in NIHSS over a 3-month period. Short- and long-term functional outcome post- @entity1 was assessed using the modified Rankin Scale at 3 months and at 2 and 7 years after @entity1 , respectively. RESULTS: No SNP was associated with @entity1 severity or recovery at 3 months and no SNP had an impact on short-term outcome. However, @entity4 was independently associated with poor functional outcome 7-years after @entity1 (OR 0.66, 95% CI 0.46-0.92; P= 0.006). CONCLUSIONS: @entity3 gene variants were not major contributors to @entity2 severity, recovery, or short-term functional outcome. However, this study suggests that variants in the @entity3 gene may contribute to poor long-term functional outcome after @entity2 .

title: Genetic variation at the XXXX locus: evidence for association with long-term outcome after @entity2 .

answer: @entity3


abstract: BACKGROUND: @entity0 with @entity1 may benefit from @entity1 or nasoalveolar molding before formal cleft lip repair. The authors compared the relative costs to insurers of these two treatment modalities and the burden of care to families. METHODS: A retrospective analysis was performed of @entity1 @entity0 treated with nasoalveolar molding or @entity1 at The @entity0 's Hospital of Philadelphia between January of 2007 and June of 2012. Demographic, appointment, and surgical data were reviewed; surgical, inpatient hospital, and orthodontic charges and costs were obtained. Multivariate linear regression and two-sample, two-tailed independent t tests were performed to compare cost and appointment data between groups. RESULTS: Forty-two cleft adhesion and 35 nasoalveolar molding @entity0 met inclusion criteria. Mean costs for nasoalveolar molding were  3550.24     667.27. Cleft adhesion costs, consisting of both hospital and surgical costs, were  9370.55     1691.79. Analysis of log costs demonstrated a significant difference between the groups, with the mean total cost for nasoalveolar molding significantly lower than that for adhesion (p < 0.0001). Nasoalveolar molding @entity0 had significantly more made, cancelled, no-show, and missed visits and a higher missed percentage than adhesion @entity0 (p < 0.0001) for all except no-show appointments, (p = 0.0199), indicating a higher burden of care to families. CONCLUSIONS: Nasoalveolar molding may cost @entity1 repair treatment than @entity1 . Third-party payers who cover adhesion and not nasoalveolar molding may not be acting in their own best interest. Nasoalveolar molding places a higher burden of care on families, and this fact should be considered in planning treatment.

title: A Comparative Cost Analysis of XXXX and Nasoalveolar Molding before Formal Cleft Lip Repair.

answer: @entity1


abstract: OBJECTIVE: To compare the effects of right unilateral (RUL) electroconvulsive therapy (ECT) and algorithm-based pharmacologic treatment (APT) on neurocognitive function in treatment-resistant @entity2 . METHOD: Inpatients with DSM-IV-TR-diagnosed, treatment-resistant @entity1 , who were acutely admitted to 1 of the 7 clinical study centers in Norway, were recruited from May 2008 to April 2011 into a prospective, randomized controlled, 6-week acute treatment trial. General neurocognitive function was assessed with the MATRICS Consensus Cognitive Battery (MCCB), and retrograde memory for autobiographical events was assessed with the Autobiographical Memory Interview-Short Form (AMI-SF) before and shortly after (mean = 23.5 days) a trial with either RUL brief-pulse ECT (mean dose = 233.3 mC) or APT. RESULTS: Seventy-three @entity0 entered, and 39 (nECT = 19, nAPT = 20) completed. Both groups showed improvements in all MCCB domain scores, with no significant differences between the study groups (no interaction effect: F   ,       = 1.52, P = NS). Improvements in neurocognitive performance were significantly correlated with reductions in @entity2 ratings posttreatment. The AMI-SF score was significantly lower (based on consistent answers from pre- to posttreatment) in the ECT group (72.9%) than in the APT group (80.8%, P = .025), indicating reduced consistency in autobiographical memory after ECT. CONCLUSIONS: General neurocognitive function was unaffected by RUL brief-pulse ECT treatment and positively related to improved mood in @entity1 . Autobiographical memory consistency was reduced in @entity0 treated with ECT. The results suggest that ECT can be used in treatment-resistant @entity1 without compromising general neurocognitive function. The clinical relevance of reduced autobiographical memory consistency in the ECT group requires further investigation. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00664976.

title: The effect of electroconvulsive therapy on neurocognitive function in treatment-resistant XXXX .

answer: @entity2


abstract: @entity5 affects approximately 5 million @entity0 in the United States. The rate of @entity1 in adults with @entity5 depending on their risk factors varies between 1-20% annually. Anticoagulation with @entity7 antagonists such as @entity6 has been the mainstay therapy but it is cumbersome and requires close follow-up. Since 2010, three new oral anticoagulants have received Food and Drug Administration approval for @entity1 prevention in @entity5 . This review summarizes data from three landmark trials: RE-LY, ROCKET-AF, and ARISTOTLE. In addition, issues relating to cost, reversal, drug interactions, and perioperative discontinuation are discussed. Compared to @entity6 , @entity9 150mg twice daily lowered the primary outcome of @entity1 /systemic @entity3 by 34% (number needed to treat/yr 169) and had similar incidence of @entity2 . Rivaroxaban demonstrated non inferiority compared to the @entity6 group for the primary outcome of @entity1 and systemic @entity3 and @entity2 . @entity10 showed a relative risk reduction for the primary outcome of 21% (number needed to treat 300), and lowered @entity2 down by 31% (number needed to treat /yr 104). @entity10 also showed a mortality benefit compared to @entity6 (3.52 vs. 3.94%/year, p 0.047). All 3 oral anticoagulants lowered rates of @entity4 . The use of @entity8 and @entity10 has been projected to reduce medical costs when compared to @entity6 , and @entity9 is projected to have similar costs. All the 3 oral anticoagulants have robust randomized controlled trials supporting their comparability to @entity6 therapy for @entity1 prevention in non @entity5 , with @entity10 showing superiority in incidence of @entity1 , @entity2 and mortality.

title: Oral anticoagulation in XXXX .

answer: @entity5


abstract: BACKGROUND: This was a retrospective study of @entity0 with @entity5 )-associated @entity1 treated with concurrent systemic therapy and radiation. METHODS: Data were extracted through chart review, and statistical analyses included frequency tabulation, chi-square, and Kaplan-Meier tests. RESULTS: Three hundred thirty-nine @entity0 were analyzed; 166 received neoadjuvant chemotherapy. One hundred thirty-six @entity0 were treated with @entity4 , 123 with cetuximab, and 59 with @entity6 . The 2-, 3-, and 5-year actuarial overall survival rates were 92%, 88%, and 78%, respectively. There were no significant differences in survival or disease control when analyzed by systemic agent. @entity7 -treated @entity0 had greater hematologic @entity3 , and required more intravenous hydration. The incidence of confluent @entity2 was highest among @entity0 treated with cetuximab. CONCLUSION: Platin and cetuximab seem to have similar efficacy when delivered concurrently with radiation in our retrospective population study. Although @entity7 did cause greater hematologic @entity3 , radiation-specific side effects seemed relatively comparable.    2015 Wiley Periodicals, Inc. Head Neck 38: E1554-E1561, 2016.

title: Comparison of systemic therapies used concurrently with radiation for the treatment of XXXX -associated @entity1 .

answer: @entity5


abstract: BACKGROUND: This was a retrospective study of @entity0 with @entity5 )-associated @entity1 treated with concurrent systemic therapy and radiation. METHODS: Data were extracted through chart review, and statistical analyses included frequency tabulation, chi-square, and Kaplan-Meier tests. RESULTS: Three hundred thirty-nine @entity0 were analyzed; 166 received neoadjuvant chemotherapy. One hundred thirty-six @entity0 were treated with @entity4 , 123 with cetuximab, and 59 with @entity6 . The 2-, 3-, and 5-year actuarial overall survival rates were 92%, 88%, and 78%, respectively. There were no significant differences in survival or disease control when analyzed by systemic agent. @entity7 -treated @entity0 had greater hematologic @entity3 , and required more intravenous hydration. The incidence of confluent @entity2 was highest among @entity0 treated with cetuximab. CONCLUSION: Platin and cetuximab seem to have similar efficacy when delivered concurrently with radiation in our retrospective population study. Although @entity7 did cause greater hematologic @entity3 , radiation-specific side effects seemed relatively comparable.    2015 Wiley Periodicals, Inc. Head Neck 38: E1554-E1561, 2016.

title: Comparison of systemic therapies used concurrently with radiation for the treatment of @entity5 -associated XXXX .

answer: @entity1