abstract: OBJECTIVE: To investigate the clinical efficacy of Panlongqi tablet (Chinese characters ) combined with lumbar facet joint release for @entity2 of type Fengshi Bizu (Chinese characters). METHODS: Since February 2012 to February 2013, 120 @entity0 with @entity2 were retrospectively studied. According to different treatment methods, 120 @entity0 with @entity2 were divided into Panlongqi tablet (Chinese characters)group and control groups, respectively. In Panlongqi tablet (Chinese characters)group, 60 @entity0 were treated by Panlongqi tablet (Chinese characters) combined with lumbar facet joints release solution including 26 males and 34 females with an average age of (60.40  3.36) years old ranging from 46 to 65 ; the course of the disease was 2 to 15 years (averaged 7.6 years). In control group the other 60 @entity0 were treated with lumbar facet joint release including 24 males and 36 females with an average age of (61.20  2.47) years old ranging from 48 to 63; the course was 3 to 14 years (averaged 6.9 years). The clinical effect of @entity0 were evaluated by JOA and ODI score before treatment, at 4 weeks and 3 months after treatment. RESULTS: All @entity0 were followed up for 4 to 7 months (means 5.6 months). After 3 months,7 cases in control group recurrenced symptoms,only 1 case in Panlongqi tablet (Chinese characters) group recurrenced. At 4 weeks and 3 months of follow-up, ODI score and JOA score of Panlongqi tablet group were much better than those of the control group. CONCLUSION: For @entity2 of type Fengshi Bizu (Chinese characters),which were treated with lumbar facet joint release with Panlongqi tablet(Chinese characters), supplemented by back muscle exercise, in relieving waist and low back @entity1 and improving functional status of lower lumbar spine, can obtain satisfactory clinical outcome, is a good method of conservative treatment for such diseases.

title: [Panlongqi tablet (Chinese characters) combined with lumbar facet joint release for the treatment of XXXX of Fengshi Bizu (Chinese characters)].

answer: @entity2


abstract: OBJECTIVE: To evaluate the clinical outcome of @entity5 for treatment of the painful @entity5 in adults. METHODS: From June 2006 to June 2012, a total of 38 feet (in 35 adult @entity0 ) with painful @entity5 underwent an fusion operation of the primary and accessory navicular bones,including 26 males and 9 females with a mean age of (32.4  7.3) years old ranging from 18 to 44 years old. The course of disease ranged from 3 to 10 months. The perioperative complications and radiological outcomes were observed and recorded. The foot function before and after operation were assessed by the American Orthopedic Foot and Ankle Society (AOFAS) midfoot score, and the easement of the @entity2 was evaluated by visual analog score (VAS). RESULTS: Two @entity0 had transient superficial @entity1 of the incision, no obvious perioperative complications occurred. All @entity0 were follow-up for (53.5  14.7) months (12 to 84 months). Bone union was confirmed on plain radiography in 32 cases (35 feet). The mean time from the operation to union was (13.7  2.3) weeks (9 to 18 weeks). @entity3 VAS score was improved obviosly than preoperative (V=12.14,P< 0.01). The talar-to-first metatarsal angle [(9.4  3.5)   vs (8.3  2.7)  , t=0.736, P>0.05)], calcaneal tilt angle [(17.7  2.2)   vs (18.9  3.4)  , t=0.794, P>0.05],talonavicular uncoverage angle [(14.3  3.4)   vs(12.5?4.6)  ,t=0.947, P>0.05) ],and height of the first tarsometatarsal joint [(14.8  3.1) mm vs (15.9  2.8) mm,t=0.814,P>0.05)] before and after operations had no statistic difference. The AOFAS midfoot score was improced from preoperative 45.6  5.3 to postoperative 82.5  7.4 (t=3.214,P< 0.01). CONCLUSION: For the painful @entity5 in adults, if the @entity0 has a large navicular bone and not complicated with @entity4 , once the conservative treatment fails, fusion of the primary and accessory naviculars may be a successful intervention. Overall, the procedure provides reliable @entity2 relief, definite foot function improvement, and good @entity0 satisfaction.

title: [Outcome of XXXX for the treatment of the painful @entity5 in adults].

answer: @entity5


abstract: OBJECTIVE: To evaluate the clinical outcome of @entity5 for treatment of the painful @entity5 in adults. METHODS: From June 2006 to June 2012, a total of 38 feet (in 35 adult @entity0 ) with painful @entity5 underwent an fusion operation of the primary and accessory navicular bones,including 26 males and 9 females with a mean age of (32.4  7.3) years old ranging from 18 to 44 years old. The course of disease ranged from 3 to 10 months. The perioperative complications and radiological outcomes were observed and recorded. The foot function before and after operation were assessed by the American Orthopedic Foot and Ankle Society (AOFAS) midfoot score, and the easement of the @entity2 was evaluated by visual analog score (VAS). RESULTS: Two @entity0 had transient superficial @entity1 of the incision, no obvious perioperative complications occurred. All @entity0 were follow-up for (53.5  14.7) months (12 to 84 months). Bone union was confirmed on plain radiography in 32 cases (35 feet). The mean time from the operation to union was (13.7  2.3) weeks (9 to 18 weeks). @entity3 VAS score was improved obviosly than preoperative (V=12.14,P< 0.01). The talar-to-first metatarsal angle [(9.4  3.5)   vs (8.3  2.7)  , t=0.736, P>0.05)], calcaneal tilt angle [(17.7  2.2)   vs (18.9  3.4)  , t=0.794, P>0.05],talonavicular uncoverage angle [(14.3  3.4)   vs(12.5?4.6)  ,t=0.947, P>0.05) ],and height of the first tarsometatarsal joint [(14.8  3.1) mm vs (15.9  2.8) mm,t=0.814,P>0.05)] before and after operations had no statistic difference. The AOFAS midfoot score was improced from preoperative 45.6  5.3 to postoperative 82.5  7.4 (t=3.214,P< 0.01). CONCLUSION: For the painful @entity5 in adults, if the @entity0 has a large navicular bone and not complicated with @entity4 , once the conservative treatment fails, fusion of the primary and accessory naviculars may be a successful intervention. Overall, the procedure provides reliable @entity2 relief, definite foot function improvement, and good @entity0 satisfaction.

title: [Outcome of @entity5 for the treatment of the painful XXXX in adults].

answer: @entity5


abstract: OBJECTIVE: To determine the importance of mechanical thrombectomy (MT) in the treatment of @entity2 . MATERIAL AND METHODS: Analysis and comparison of randomized controlled trials (RCT) of MT versus @entity5 ( @entity5 ) considering pathophysiological and logistic aspects. RESULTS: The use of MT is more effective than @entity5 for internal carotid artery terminus (ICAT), M1 segment and tandem occlusions, i.e. proximal internal carotid artery (ICA) @entity3 or @entity4 , even in @entity0 older than 75-80 years of age. Due to the small sample sizes this question cannot be answered for @entity0 with M2 occlusions. It is still uncertain whether MT is needed in @entity0 with a low National Institutes of @entity1 scale (NIHSS) score, whether @entity5 is needed before MT and what type of imaging should be performed. Approximately one third of eligible @entity0 currently undergo MT in Germany. Results from RCTs with stent retrievers for @entity0 with vertebrobasilar artery occlusions are lacking. CONCLUSION: After becoming established as a first-line therapy for @entity0 with ICAT, M1 segment and tandem occlusions, the effectiveness of MT with stent retrievers has to proven in @entity0 with more distal occlusions, low NIHSS scores and even vertebrobasilar artery occlusions.

title: [Mechanical thrombectomy for acute XXXX : Current evidence and open questions].

answer: @entity2


abstract: 196 cases of @entity6 of the upper limb with well-established ischaemia are presented. In all cases tight external circumferential splintage was the primary factor. 59.2% of these @entity0 had been initially treated by "bone setters". 54.6% had @entity2 of the forearm; supracondylar fracture of the humerus was seen in 10.7% and 17.9% had no evidence of @entity1 . Different patterns of @entity5 are recognised and the severity of the contracture is found to be related to the extent of @entity4 . Sensory recovery occurs in a proximodistal direction even following total ischaemia and @entity3 . Motor recovery, however, does not seem to take place. Sensory recovery in the forearm proceeds rapidly in the first six months; thereafter it is less significant. However, the sensory recovery in the hand is significant only after more than twelve months. Since sensory recovery occurs even after total @entity3 it is postulated that such nerves recover and regenerate in course of time.

title: XXXX and recovery following ischaemia of the upper limb.

answer: @entity5


abstract: PURPOSE: To investigate the 5-year outcome of @entity0 treated with self-expanding covered stents for superficial femoral artery (SFA) occlusive disease and identify parameters that could predict loss of primary patency. METHODS: In a dual-center study, 315 consecutive @entity0 (mean age 69.0  10.1 years; 232 @entity0 ) treated for @entity1 in 334 limbs with Viabahn self-expanding covered stents between 2001 and 2014 were retrospectively analyzed. Mean lesion length was 11.7  8.8 cm, and half of the lesions were classified as TASC II C/D. Five-year patency rates were calculated, and Cox regression analyses were performed to assess potential factors affecting patency. RESULTS: All-cause mortality at 5 years was 14.1%. Primary patency rates at 1, 3, and 5 years were 72.2%, 51.8%, and 47.6%, respectively, with secondary patency rates of 86.2%, 78.7%, and 77.5%. Parameters predicting loss of primary patency in a univariate analysis were covered stent diameter (p=0.001), the number of covered stents per lesion (p=0.015), and TASC II D classification (p=0.007). Covered stent diameter was the only parameter predicting loss of primary patency in the multivariate regression analysis (p=0.001), with 7-mm covered stents having superior performance. CONCLUSION: Five-year patency rates of self-expanding covered stents inserted for @entity1 are within an acceptable range. Covered stent diameter is the most relevant factor in predicting loss of primary patency, and thus, an adequate diameter of the distal landing site seems to be among the most important factors in the decision-making process. In smaller vessels, one should not use covered stents but venous conduits, as oversizing may be detrimental.

title: Five-Year Outcome of Self-Expanding Covered Stents for Superficial Femoral XXXX and an Analysis of Factors Predicting Failure.

answer: @entity1


abstract: PURPOSE: @entity1 ( @entity1 ) is a rare condition described as the delayed angiographic passage of a contrast agent in the absence of @entity5 in epicardial coronary arteries. @entity6 have been described in the presence of @entity1 . However, the effect of @entity1 on LV twist functions has not been assessed. We aimed to evaluate the effects of @entity1 on LV twist mechanics using speckle tracking echocardiography (STE). METHODS: Twenty @entity1 @entity0 (24-60  years) were enrolled according to the exclusion criteria. Twenty subjects with similar demographic characteristics and normal coronary arteries were the controls. @entity0 were evaluated with conventional echocardiography and STE. RESULTS: The general characteristics of the two groups were similar. LV twist, LV torsion, and @entity4 were impaired in the @entity1 group (P  =  0.015, P  =  0.012, and P  <  0.001, respectively). Time @entity7 ( @entity7 ) and time to peak untwisting (TPU) were prolonged in @entity1 @entity0 (P  <  0.001 and P  <  0.001, respectively). In the @entity1 group, rotation-deformation delay was @entity2 (GLS) was lower (P  <  0.001). The thrombolysis in @entity3 (TIMI) frame count was negatively correlated with LV twist, LV torsion and @entity4 (P  =  0.002, r  =  -0.624; P  =  0.002, r  =  -0.624; and P  =  0.002, r  =  -0.632, respectively). CONCLUSIONS: We demonstrated that LV twist mechanics are impaired in @entity1 @entity0 . Worse LV twist parameters were associated with greater TIMI frame count.

title: Left Ventricular Twist Mechanics Are Impaired in XXXX with Coronary Slow Flow.

answer: @entity0


abstract: UNASSIGNED: The objective of this study is to examine the effect of milk powder supplementation with different @entity2 contents on @entity1 ( @entity1 ) in postmenopausal Chinese @entity0 , and to determine a more appropriate dose of @entity2 supplementation. A 2-year, randomized controlled double-blind trial. Postmenopausal @entity0 (n  =  210) aged 50-65  years were recruited and assigned randomly into three @entity2 supplementation groups. All @entity0 received milk powder supplementation with different @entity2 contents (300, 600, and 900  mg per day for groups A, B, and C, respectively) and all groups received 800  IU of @entity3 per day. During the follow-up period, @entity1 of the left hip and lumbar spine (as the main indicator) was measured using dual-energy X-ray absorptiometry at the baseline, 1 and 2  years. Both three @entity1 measures and the changes of @entity1 over 2  years were used to analyze. Before adjusting for covariates, @entity1 in group A of the lumbar spine and groups A and B of greater trochanter decreased significantly from the baseline over time but increased significantly in the rest groups of the lumbar spine and greater trochanter and in three groups of Ward's triangle. There were significant differences across the three groups for changes of @entity1 in the greater trochanter and Ward's triangle. When adjusting for covariates, there were significant decreases with time in group A of the spine (P  =  0.001), groups A and B of greater trochanter (P  =  0.0002 and P  =  0.04, respectively) and increases in groups B and C of Ward's triangle (P  =  0.03 and P  =  0.004, respectively). @entity1 change in the greater trochanter was significantly different among three groups. For healthy postmenopausal @entity0 , high @entity2 milk powder supplementation was better in retarding @entity4 than medium and low @entity2 in the greater trochanter. Considering the dietary @entity2 intake of postmenopausal @entity0 in north of China, a dose of 900  mg/day is considered as the most appropriate @entity2 supplementation for greater trochanter but not for other sites.

title: Effect of Milk Powder Supplementation with Different XXXX Contents on Bone Mineral Density of Postmenopausal @entity0 in Northern China: A Randomized Controlled Double-Blind Trial.

answer: @entity2


abstract: UNASSIGNED: The objective of this study is to examine the effect of milk powder supplementation with different @entity2 contents on @entity1 ( @entity1 ) in postmenopausal Chinese @entity0 , and to determine a more appropriate dose of @entity2 supplementation. A 2-year, randomized controlled double-blind trial. Postmenopausal @entity0 (n  =  210) aged 50-65  years were recruited and assigned randomly into three @entity2 supplementation groups. All @entity0 received milk powder supplementation with different @entity2 contents (300, 600, and 900  mg per day for groups A, B, and C, respectively) and all groups received 800  IU of @entity3 per day. During the follow-up period, @entity1 of the left hip and lumbar spine (as the main indicator) was measured using dual-energy X-ray absorptiometry at the baseline, 1 and 2  years. Both three @entity1 measures and the changes of @entity1 over 2  years were used to analyze. Before adjusting for covariates, @entity1 in group A of the lumbar spine and groups A and B of greater trochanter decreased significantly from the baseline over time but increased significantly in the rest groups of the lumbar spine and greater trochanter and in three groups of Ward's triangle. There were significant differences across the three groups for changes of @entity1 in the greater trochanter and Ward's triangle. When adjusting for covariates, there were significant decreases with time in group A of the spine (P  =  0.001), groups A and B of greater trochanter (P  =  0.0002 and P  =  0.04, respectively) and increases in groups B and C of Ward's triangle (P  =  0.03 and P  =  0.004, respectively). @entity1 change in the greater trochanter was significantly different among three groups. For healthy postmenopausal @entity0 , high @entity2 milk powder supplementation was better in retarding @entity4 than medium and low @entity2 in the greater trochanter. Considering the dietary @entity2 intake of postmenopausal @entity0 in north of China, a dose of 900  mg/day is considered as the most appropriate @entity2 supplementation for greater trochanter but not for other sites.

title: Effect of Milk Powder Supplementation with Different @entity2 Contents on Bone Mineral Density of Postmenopausal XXXX in Northern China: A Randomized Controlled Double-Blind Trial.

answer: @entity0


abstract: UNASSIGNED: Muscle protein synthesis (MPS) is stimulated by resistance exercise (RE) and is further stimulated by protein ingestion. The summation of periods of RE-induced increases in MPS can induce @entity0 chronically. As such, studying the response of MPS with @entity2 ( @entity2 ) is informative, as adaptations in this process can modulate muscle mass gain. Previous studies have shown that the amplitude and duration of increases in MPS after an acute bout of RE are modulated by an individual's training status. Nevertheless, it has been shown that the initial responses of MPS to RE and nutrition are not correlated with subsequent @entity0 . Thus, early acute responses of MPS in the hours after RE, in an untrained state, do not capture how MPS can affect RE-induced @entity1 . The purpose of this review is provide an in-depth understanding of the dynamic process of @entity1 throughout @entity2 by examining all of the available data on MPS after RE and in different phases of an @entity2 programme. Analysis of the time course and the overall response of MPS is critical to determine the potential protein accretion after an RE bout. Exercise-induced increases in MPS are shorter lived and peak earlier in the trained state than in the untrained state, resulting in a smaller overall muscle protein synthetic response in the trained state. Thus, @entity2 induces a dampening of the MPS response, potentially limiting protein accretion, but when this occurs remains unknown.

title: A Review of Resistance Training-Induced Changes in Skeletal Muscle Protein Synthesis and Their Contribution to XXXX .

answer: @entity0


abstract: UNASSIGNED: Defects in articular cartilage ultimately result in @entity5 . Repairing cartilage defects requires cell sources. We developed an  approach to generate scaffoldless hyaline cartilage from @entity0 induced pluripotent stem cells (hiPSCs). We initially generated an hiPSC line that specifically expressed GFP in cartilage when @entity4 was formed. We optimized the culture conditions and found @entity8 , @entity9 ( @entity9 ), and @entity10 critical for GFP expression and thus chondrogenic differentiation of the hiPSCs. The subsequent use of scaffoldless suspension culture contributed to purification, producing homogenous cartilaginous particles. Subcutaneous transplantation of the hiPSC-derived particles generated hyaline cartilage that expressed type II collagen, but not type I collagen, in @entity6 @entity2 . Transplantation of the particles into joint surface defects in @entity6 @entity3 and immunosuppressed mini- @entity7 indicated that neocartilage survived and had potential for integration into native cartilage. The @entity6 @entity2 and @entity3 suffered from neither @entity1 nor ectopic tissue formation. The hiPSC-derived cartilaginous particles constitute a viable cell source for regenerating cartilage defects.

title: Generation of Scaffoldless Hyaline Cartilaginous Tissue from XXXX iPSCs.

answer: @entity0


abstract: A 57-year-old @entity0 presented with @entity4 , dyspnoea and coffee grounds emesis. He was haemodynamically stable without significant drop in haemoglobin. He suddenly developed @entity7 with wide complex @entity3 and became @entity5 . CT scan of the head revealed @entity9 and @entity8 . Given the recent history of radiofrequency ablation for @entity6 , @entity1 ( @entity1 ) was suspected. CT angiography of the thorax showed a 5   mm diverticulum on the posterior wall of the left atrium, also raising suspicion for @entity1 . The @entity0 was taken to the operating room. An @entity1 was found and repaired. He did not have any further @entity2 . There was no neurological recovery at day 11 and life support was withdrawn per his family's request. This case highlights the importance of obtaining history of recent cardiac procedures in @entity0 presenting with an @entity2 . An oesophagogastroduodenoscopy in this @entity0 could have been instantaneously deadly.

title: Unusual cause of XXXX , when OGD could be fatal.

answer: @entity2


abstract: UNASSIGNED: Introduction: Rotavirus is the principal cause of nosocomial @entity2 (NAGE) under 5 years of age. The objectiveis to evaluate the validity and reliability of the @entity1 ( @entity1 ) in estimating the NAGE caused by rotavirus (NAGER) and to analyze any changes during the three years that the Rotarix   and Rotateq   vaccines were used in Spain.Material and methods: A descriptive, retrospectivestudy was carried out in the University Hospital of @entity3 (Spain) between 2003-2009 using the @entity1 , positive microbiological results for rotavirus (PMRs), and medical histories.Three methods of estimation were used: 1) An ICD-9-CM code 008.61 in the secondary diagnosis fields (DIAG2) of @entity1 ; 2) method 1 and/or PMRs with a current or recent hospitalization; and 3) the reference method or method 2 contrasted with @entity0 medical histories. The validity of methods 1 and 2 was determined -sensitivity, specificity, predictive values and likelihood ratios (LRs)-, along with their agreement with method 3 (Kappa coefficient). In addition, the incidence rate ratio between the NAGER rate in 2007-2009 (commercialization period of both vaccines) was calculated with respect to 2003-2005 (precommercialization period).Results: Method 1 identified 65 records with a DIAG2 of 008.61. Method 2 found 62 probable cases, and the reference method, 49 true cases. The sensitivity of the @entity1 was 67 %,the positive predictive value was 51 %, and both negative LR (LR-) and reliability were moderate (LR- 0.33, Kappa coefficient 0.58). During 2007-2009, the NARGE decreased by 5 cases per 103 hospitalizations and by 9 per 104 days of hospitalization. Method 2 overestimated both the decline in incidence by 2 per 103 hospitalizations and the decreased risk per day of stay by 10 %. The @entity1 found no differences between the two three-year periods, but, like method 2, showed an excellent level of diagnostic evidence (LR+ 67).Conclusion: The @entity1 taken together with microbiological results, is more exact, safer and more reliable than the @entity1 alone in estimating NAGER; and more useful in ruling out it. Nevertheless, the @entity1 alone may be used to estimate and compare such disease in contexts with different prevalences.

title: Validity and reliability of the minimum basic data set in estimating nosocomial XXXX caused by rotavirus.

answer: @entity2


abstract: The in-vitro activity of @entity6 was evaluated against 381 anaerobic clinical isolates and compared with that of @entity2 , @entity3 , @entity4 ( @entity4 ), @entity5 and @entity1 . Test isolates included strains with unknown resistance to the beta-lactam drugs, and two @entity0 strains that could inactivate @entity3 . @entity6 and @entity2 demonstrated superior activity against all the anaerobic bacteria tested, with MIC90s less than or equal to 1 mg/l. @entity6 was generally one- to two-fold more active than @entity2 . Resistance to both was demonstrated by the two Bact. fragilis strains that inactivated @entity3 and by one strain of Fusobacterium; these three strains were also resistant to the other drugs studied. There were no other resistant strains to either @entity6 or @entity2 . @entity5 and @entity1 were the least active against the Bact. fragilis group, with resistance rates of 33 and 47%, respectively. Strains resistant to @entity3 , latamoxef, @entity5 and @entity1 were found among some Clostridium spp. The Gram-positive cocci and Gram-positive bacilli were sensitive to all the drugs evaluated.

title: Susceptibility of anaerobic bacteria to XXXX and other beta-lactam antibiotics.

answer: @entity6


abstract: PURPOSE: The medial branch of the posterior ramus of the lumbar spinal nerve is well known to be innervated independently and to end in the multifidus muscle without @entity3 . This prospective cohort study aimed to determine the diagnostic specificity and sensitivity of @entity1 ( @entity1 ) by needle electromyography (N-EMG) for lumbar foraminal and lateral exit-zone @entity5 (LF/LEZS). METHODS: We enrolled 61 consecutive @entity0 experiencing @entity4 and/or @entity2 in the L4 or L5 regions with suspicious LF/LEZS. The Japanese Orthopedic Association (JOA) score, Visual Analog Scale (VAS) for @entity2 , and N-EMG were examined. In this study protocol, all @entity0 received at least 3  months of conservative therapy. Surgery was performed on @entity0 who experienced less than 50  % VAS @entity2 relief compared with their initial score after confirming the responsible level by lumbar nerve root block. The specificity of N-EMG was the proportion of @entity0 who improved with conservative therapies (non-surgery) after 3  months. The sensitivity of N-EMG was the proportion of @entity0 who improved with surgical therapies (surgery) after more than 12  months. RESULTS: Twenty-three @entity0 underwent surgery. The initial lower JOA, positive Kemp test and motor weakness were significantly higher in the surgery group. The @entity1 by N-EMG indicated that 34 of 38 @entity0 were negative in the non-surgery group. In the surgery group, 21 of 23 @entity0 were positive. The diagnostic sensitivity and specificity were 91.3 and 92.1  %, respectively. CONCLUSIONS: Needle electromyography is a simple and available additional method for the diagnosis of LF/LEZS.

title: Diagnostic accuracy of multifidus muscle spontaneous activity by needle electromyography for the detection of lumbar foraminal and lateral exit-zone XXXX .

answer: @entity5


abstract: BACKGROUND: Mycotic thoracic aortic @entity4 are a life-threatening diagnosis and carry a high risk of morbidity and mortality in the perioperative setting. Traditional open repair consists of debridement, drainage, and either in situ or extra-anatomic bypass. @entity6 portends a dismal prognosis; however, emergent endovascular repair of ruptured @entity15 has been described in the literature and we present a case of successful endovascular treatment of a ruptured mycotic descending @entity12 . CASE REPORT: We report the case of a 42-year-old male with @entity1 and active intravenous drug use who presented with 3 weeks of @entity5 , @entity10 , and hemoptysis, and on computed tomography scan was found to have a contained 4.1-cm ruptured mycotic @entity12 . Blood cultures were positive for @entity14 -resistant @entity7 . Emergent repair was recommended because of likelihood of further @entity3 and @entity2 . Thoracic endovascular aortic repair (TEVAR) was performed using a @entity9 -soaked stent graft without complication. At 2-year follow-up, the @entity0 was asymptomatic and imaging demonstrated the stent graft in excellent position, without @entity8 , and complete resolution of the @entity4 sac. CONCLUSIONS: TEVAR can be safely employed to treat a @entity11 when open repair is not possible because of @entity0 's comorbidity or complex @entity3 , as these @entity0 face imminent @entity2 . Long-term follow-up is necessary for detection of @entity8 , recurrence, or propagation of the @entity4 , and persistent @entity13 .

title: Successful Emergent Endovascular Repair of a Ruptured Mycotic XXXX .

answer: @entity12


abstract: OBJECTIVE: To assess rates of treatment-related complications after radical prostatectomy or radiotherapy monotherapy, using propensity score matching to account for baseline differences between these @entity0 populations. METHODS: On the basis of a population-based study of @entity0 undergoing surgery or radiotherapy for @entity2 in Ontario between 2002 and 2009, we undertook a propensity score-matched analysis including age, comorbidity, and year of treatment to assess treatment-related complication end points. These included hospital admission; urologic, rectal, or anal procedures; open surgeries; and @entity1 . RESULTS: From the original cohort of 32,465 @entity0 , 15,870 (48.9%) had surgery and 16,595 (51.1%) had radiation. Propensity score matching produced 8797 pairs (17,594 @entity0 ). Among these, when compared with @entity0 treated with surgery, those treated with radiation experienced fewer admissions to hospital (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.78-0.92) and urologic procedures (HR, 0.50; 95% CI, 0.46-0.53) at year 1 but higher rates at year 3 (HR, 5.65; 95% CI, 4.61-6.91 and HR, 1.86; 95% CI, 1.62-2.13, respectively) and year 5. Although there was no significant difference in open surgeries at year 1, @entity0 undergoing radiotherapy were at higher risk by year 3 (HR, 2.06; 95% CI, 1.23-3.47) and this rose by year 5. Over the study period, @entity0 undergoing radiotherapy experienced more @entity3 (HR, 2.64; 95% CI, 2.37-2.95) and were diagnosed with more @entity1 (HR, 2.44; 95% CI, 1.16-5.14). Direct matching produced similar results. CONCLUSION: From a propensity score-matched analysis, we found that @entity0 undergoing radiation therapy for @entity2 had higher rates of long-term complications in all 5 categories studied than @entity0 undergoing surgery.

title: Complications After Radical Prostatectomy or Radiotherapy for XXXX : Results of a Population-based, Propensity Score-matched Analysis.

answer: @entity2


abstract: BACKGROUND: Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, @entity3 , and @entity4 . Research to develop nutritional interventions to prevent or treat @entity2 and its associated diseases is greatly needed. Previously, we demonstrated the ability of @entity8 ( @entity9 ) to prevent high-fat (HF) diet-induced @entity2 , insulin resistance, and @entity3 in @entity0 . OBJECTIVE: The objective of the current study was to determine the mechanisms mediating the anti-inflammatory and antilipogenic actions of @entity9 . METHODS: In a previous study, male C57BL/6J @entity0 were fed a low-fat diet (10% of energy from fat), an HF diet (45% of energy from fat), or an HF diet supplemented with @entity9 (45% of energy from fat; 36 g/kg @entity9 ; HF+ @entity9 ) for 11 wk or an HF diet for 6 wk and then switched to the HF+ @entity9 diet for 5 wk. In this study, we used histology/immunohistochemistry, gene expression, and metabolomic analyses of white adipose tissue from these @entity0 . In addition, cultured @entity0 3T3-L1 adipocytes were treated with 100  M @entity9 for 48 h and then used for extracellular flux assays with untreated 3T3-L1 adipocytes used as a control. RESULTS: Compared with the HF diet, the HF+ @entity9 diet significantly reduced body weight, @entity7 , adipocyte size, and macrophage infiltration into adipose tissue. No significant differences in overall body weight or fat pad weights were observed between HF-fed @entity0 vs. those fed the HF+ @entity9 diet for a short time after first inducing @entity2 with the HF diet. Interestingly, both histology and immunohistochemistry results showed a significantly lower mean adipocyte size and macrophage infiltration in @entity0 fed the HF diet and then switched to the HF+ @entity9 diet vs. those fed HF diets only. This indicated that @entity9 was able to prevent as well as reverse HF-diet-induced adipocyte @entity3 and @entity6 and that some of the metabolic effects of @entity9 were independent of body weight or @entity7 . In addition, adipose tissue metabolomic data and cultured adipocyte extracellular flux bioenergetic assays indicated that @entity9 also regulated mitochondrial function by increasing @entity5 oxidation and @entity1 consumption, respectively. CONCLUSION: With the use of @entity0 and cultured adipocytes, we showed that @entity9 ameliorates HF-diet effects at least in part by increasing @entity1 consumption and @entity5 oxidation and reducing adipocyte size, adipogenesis, and adipose tissue @entity3 , independent of @entity2 .

title: @entity8 reduces adipocyte @entity6 and @entity3 in diet-induced @entity2 @entity0 in an XXXX -independent manner.

answer: @entity7


abstract: BACKGROUND: Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, @entity3 , and @entity4 . Research to develop nutritional interventions to prevent or treat @entity2 and its associated diseases is greatly needed. Previously, we demonstrated the ability of @entity8 ( @entity9 ) to prevent high-fat (HF) diet-induced @entity2 , insulin resistance, and @entity3 in @entity0 . OBJECTIVE: The objective of the current study was to determine the mechanisms mediating the anti-inflammatory and antilipogenic actions of @entity9 . METHODS: In a previous study, male C57BL/6J @entity0 were fed a low-fat diet (10% of energy from fat), an HF diet (45% of energy from fat), or an HF diet supplemented with @entity9 (45% of energy from fat; 36 g/kg @entity9 ; HF+ @entity9 ) for 11 wk or an HF diet for 6 wk and then switched to the HF+ @entity9 diet for 5 wk. In this study, we used histology/immunohistochemistry, gene expression, and metabolomic analyses of white adipose tissue from these @entity0 . In addition, cultured @entity0 3T3-L1 adipocytes were treated with 100  M @entity9 for 48 h and then used for extracellular flux assays with untreated 3T3-L1 adipocytes used as a control. RESULTS: Compared with the HF diet, the HF+ @entity9 diet significantly reduced body weight, @entity7 , adipocyte size, and macrophage infiltration into adipose tissue. No significant differences in overall body weight or fat pad weights were observed between HF-fed @entity0 vs. those fed the HF+ @entity9 diet for a short time after first inducing @entity2 with the HF diet. Interestingly, both histology and immunohistochemistry results showed a significantly lower mean adipocyte size and macrophage infiltration in @entity0 fed the HF diet and then switched to the HF+ @entity9 diet vs. those fed HF diets only. This indicated that @entity9 was able to prevent as well as reverse HF-diet-induced adipocyte @entity3 and @entity6 and that some of the metabolic effects of @entity9 were independent of body weight or @entity7 . In addition, adipose tissue metabolomic data and cultured adipocyte extracellular flux bioenergetic assays indicated that @entity9 also regulated mitochondrial function by increasing @entity5 oxidation and @entity1 consumption, respectively. CONCLUSION: With the use of @entity0 and cultured adipocytes, we showed that @entity9 ameliorates HF-diet effects at least in part by increasing @entity1 consumption and @entity5 oxidation and reducing adipocyte size, adipogenesis, and adipose tissue @entity3 , independent of @entity2 .

title: @entity8 reduces adipocyte @entity6 and @entity3 in diet-induced XXXX @entity0 in an @entity7 -independent manner.

answer: @entity2


abstract: BACKGROUND: Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, @entity3 , and @entity4 . Research to develop nutritional interventions to prevent or treat @entity2 and its associated diseases is greatly needed. Previously, we demonstrated the ability of @entity8 ( @entity9 ) to prevent high-fat (HF) diet-induced @entity2 , insulin resistance, and @entity3 in @entity0 . OBJECTIVE: The objective of the current study was to determine the mechanisms mediating the anti-inflammatory and antilipogenic actions of @entity9 . METHODS: In a previous study, male C57BL/6J @entity0 were fed a low-fat diet (10% of energy from fat), an HF diet (45% of energy from fat), or an HF diet supplemented with @entity9 (45% of energy from fat; 36 g/kg @entity9 ; HF+ @entity9 ) for 11 wk or an HF diet for 6 wk and then switched to the HF+ @entity9 diet for 5 wk. In this study, we used histology/immunohistochemistry, gene expression, and metabolomic analyses of white adipose tissue from these @entity0 . In addition, cultured @entity0 3T3-L1 adipocytes were treated with 100  M @entity9 for 48 h and then used for extracellular flux assays with untreated 3T3-L1 adipocytes used as a control. RESULTS: Compared with the HF diet, the HF+ @entity9 diet significantly reduced body weight, @entity7 , adipocyte size, and macrophage infiltration into adipose tissue. No significant differences in overall body weight or fat pad weights were observed between HF-fed @entity0 vs. those fed the HF+ @entity9 diet for a short time after first inducing @entity2 with the HF diet. Interestingly, both histology and immunohistochemistry results showed a significantly lower mean adipocyte size and macrophage infiltration in @entity0 fed the HF diet and then switched to the HF+ @entity9 diet vs. those fed HF diets only. This indicated that @entity9 was able to prevent as well as reverse HF-diet-induced adipocyte @entity3 and @entity6 and that some of the metabolic effects of @entity9 were independent of body weight or @entity7 . In addition, adipose tissue metabolomic data and cultured adipocyte extracellular flux bioenergetic assays indicated that @entity9 also regulated mitochondrial function by increasing @entity5 oxidation and @entity1 consumption, respectively. CONCLUSION: With the use of @entity0 and cultured adipocytes, we showed that @entity9 ameliorates HF-diet effects at least in part by increasing @entity1 consumption and @entity5 oxidation and reducing adipocyte size, adipogenesis, and adipose tissue @entity3 , independent of @entity2 .

title: @entity8 reduces adipocyte @entity6 and XXXX in diet-induced @entity2 @entity0 in an @entity7 -independent manner.

answer: @entity3


abstract: BACKGROUND: Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, @entity3 , and @entity4 . Research to develop nutritional interventions to prevent or treat @entity2 and its associated diseases is greatly needed. Previously, we demonstrated the ability of @entity8 ( @entity9 ) to prevent high-fat (HF) diet-induced @entity2 , insulin resistance, and @entity3 in @entity0 . OBJECTIVE: The objective of the current study was to determine the mechanisms mediating the anti-inflammatory and antilipogenic actions of @entity9 . METHODS: In a previous study, male C57BL/6J @entity0 were fed a low-fat diet (10% of energy from fat), an HF diet (45% of energy from fat), or an HF diet supplemented with @entity9 (45% of energy from fat; 36 g/kg @entity9 ; HF+ @entity9 ) for 11 wk or an HF diet for 6 wk and then switched to the HF+ @entity9 diet for 5 wk. In this study, we used histology/immunohistochemistry, gene expression, and metabolomic analyses of white adipose tissue from these @entity0 . In addition, cultured @entity0 3T3-L1 adipocytes were treated with 100  M @entity9 for 48 h and then used for extracellular flux assays with untreated 3T3-L1 adipocytes used as a control. RESULTS: Compared with the HF diet, the HF+ @entity9 diet significantly reduced body weight, @entity7 , adipocyte size, and macrophage infiltration into adipose tissue. No significant differences in overall body weight or fat pad weights were observed between HF-fed @entity0 vs. those fed the HF+ @entity9 diet for a short time after first inducing @entity2 with the HF diet. Interestingly, both histology and immunohistochemistry results showed a significantly lower mean adipocyte size and macrophage infiltration in @entity0 fed the HF diet and then switched to the HF+ @entity9 diet vs. those fed HF diets only. This indicated that @entity9 was able to prevent as well as reverse HF-diet-induced adipocyte @entity3 and @entity6 and that some of the metabolic effects of @entity9 were independent of body weight or @entity7 . In addition, adipose tissue metabolomic data and cultured adipocyte extracellular flux bioenergetic assays indicated that @entity9 also regulated mitochondrial function by increasing @entity5 oxidation and @entity1 consumption, respectively. CONCLUSION: With the use of @entity0 and cultured adipocytes, we showed that @entity9 ameliorates HF-diet effects at least in part by increasing @entity1 consumption and @entity5 oxidation and reducing adipocyte size, adipogenesis, and adipose tissue @entity3 , independent of @entity2 .

title: @entity8 reduces adipocyte XXXX and @entity3 in diet-induced @entity2 @entity0 in an @entity7 -independent manner.

answer: @entity6


abstract: BACKGROUND: Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, @entity3 , and @entity4 . Research to develop nutritional interventions to prevent or treat @entity2 and its associated diseases is greatly needed. Previously, we demonstrated the ability of @entity8 ( @entity9 ) to prevent high-fat (HF) diet-induced @entity2 , insulin resistance, and @entity3 in @entity0 . OBJECTIVE: The objective of the current study was to determine the mechanisms mediating the anti-inflammatory and antilipogenic actions of @entity9 . METHODS: In a previous study, male C57BL/6J @entity0 were fed a low-fat diet (10% of energy from fat), an HF diet (45% of energy from fat), or an HF diet supplemented with @entity9 (45% of energy from fat; 36 g/kg @entity9 ; HF+ @entity9 ) for 11 wk or an HF diet for 6 wk and then switched to the HF+ @entity9 diet for 5 wk. In this study, we used histology/immunohistochemistry, gene expression, and metabolomic analyses of white adipose tissue from these @entity0 . In addition, cultured @entity0 3T3-L1 adipocytes were treated with 100  M @entity9 for 48 h and then used for extracellular flux assays with untreated 3T3-L1 adipocytes used as a control. RESULTS: Compared with the HF diet, the HF+ @entity9 diet significantly reduced body weight, @entity7 , adipocyte size, and macrophage infiltration into adipose tissue. No significant differences in overall body weight or fat pad weights were observed between HF-fed @entity0 vs. those fed the HF+ @entity9 diet for a short time after first inducing @entity2 with the HF diet. Interestingly, both histology and immunohistochemistry results showed a significantly lower mean adipocyte size and macrophage infiltration in @entity0 fed the HF diet and then switched to the HF+ @entity9 diet vs. those fed HF diets only. This indicated that @entity9 was able to prevent as well as reverse HF-diet-induced adipocyte @entity3 and @entity6 and that some of the metabolic effects of @entity9 were independent of body weight or @entity7 . In addition, adipose tissue metabolomic data and cultured adipocyte extracellular flux bioenergetic assays indicated that @entity9 also regulated mitochondrial function by increasing @entity5 oxidation and @entity1 consumption, respectively. CONCLUSION: With the use of @entity0 and cultured adipocytes, we showed that @entity9 ameliorates HF-diet effects at least in part by increasing @entity1 consumption and @entity5 oxidation and reducing adipocyte size, adipogenesis, and adipose tissue @entity3 , independent of @entity2 .

title: @entity8 reduces adipocyte @entity6 and @entity3 in diet-induced @entity2 XXXX in an @entity7 -independent manner.

answer: @entity0


abstract: BACKGROUND: Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, @entity3 , and @entity4 . Research to develop nutritional interventions to prevent or treat @entity2 and its associated diseases is greatly needed. Previously, we demonstrated the ability of @entity8 ( @entity9 ) to prevent high-fat (HF) diet-induced @entity2 , insulin resistance, and @entity3 in @entity0 . OBJECTIVE: The objective of the current study was to determine the mechanisms mediating the anti-inflammatory and antilipogenic actions of @entity9 . METHODS: In a previous study, male C57BL/6J @entity0 were fed a low-fat diet (10% of energy from fat), an HF diet (45% of energy from fat), or an HF diet supplemented with @entity9 (45% of energy from fat; 36 g/kg @entity9 ; HF+ @entity9 ) for 11 wk or an HF diet for 6 wk and then switched to the HF+ @entity9 diet for 5 wk. In this study, we used histology/immunohistochemistry, gene expression, and metabolomic analyses of white adipose tissue from these @entity0 . In addition, cultured @entity0 3T3-L1 adipocytes were treated with 100  M @entity9 for 48 h and then used for extracellular flux assays with untreated 3T3-L1 adipocytes used as a control. RESULTS: Compared with the HF diet, the HF+ @entity9 diet significantly reduced body weight, @entity7 , adipocyte size, and macrophage infiltration into adipose tissue. No significant differences in overall body weight or fat pad weights were observed between HF-fed @entity0 vs. those fed the HF+ @entity9 diet for a short time after first inducing @entity2 with the HF diet. Interestingly, both histology and immunohistochemistry results showed a significantly lower mean adipocyte size and macrophage infiltration in @entity0 fed the HF diet and then switched to the HF+ @entity9 diet vs. those fed HF diets only. This indicated that @entity9 was able to prevent as well as reverse HF-diet-induced adipocyte @entity3 and @entity6 and that some of the metabolic effects of @entity9 were independent of body weight or @entity7 . In addition, adipose tissue metabolomic data and cultured adipocyte extracellular flux bioenergetic assays indicated that @entity9 also regulated mitochondrial function by increasing @entity5 oxidation and @entity1 consumption, respectively. CONCLUSION: With the use of @entity0 and cultured adipocytes, we showed that @entity9 ameliorates HF-diet effects at least in part by increasing @entity1 consumption and @entity5 oxidation and reducing adipocyte size, adipogenesis, and adipose tissue @entity3 , independent of @entity2 .

title: XXXX reduces adipocyte @entity6 and @entity3 in diet-induced @entity2 @entity0 in an @entity7 -independent manner.

answer: @entity8


abstract: BACKGROUND: A healthy diet rich in fish, fruit, and vegetables, but moderate in @entity6 and low in dairy products and meat, has been associated with a lower rate of incident @entity5 ( @entity5 ). The underlying mechanisms, however, remain unclear. @entity7 and low-grade @entity3 play important roles in @entity5 . A healthy diet might modify these phenomena. OBJECTIVE: We investigated the associations between the above food groups and overall biomarker scores of @entity7 and low-grade @entity3 in a 7-y longitudinal study. METHODS: Using longitudinal data from 557 @entity0 at increased @entity5 risk from the CODAM (Cohort on @entity2 and @entity11 Maastricht) Study, we assessed diet intake by food-frequency questionnaire and measured plasma biomarkers of @entity7 [von Willebrand factor, soluble vascular cell adhesion molecule 1, soluble endothelial selectin, soluble thrombomodulin, soluble intercellular adhesion molecule 1 (sICAM-1)] and low-grade @entity3 [ @entity12 , serum amyloid A, @entity9 , @entity10 , @entity1 @entity4 factor a, and sICAM-1]. At baseline, @entity0 were aged 59.6    6.9 y. Measurements were performed then and after 7 y. Biomarkers were combined into overall scores (sum of z scores; higher scores indicating worse function). Longitudinal data were analyzed with generalized estimating equations and adjusted for sex, age, @entity8 metabolism, energy intake, body mass index, physical activity, @entity6 consumption, and smoking. RESULTS: Higher consumption of fish (per 100 g/wk), but not total consumption of vegetables, fruit, @entity6 -containing beverages, dairy products, or meat, was associated with a lower overall @entity7 score over 7 y (b: -0.027; 95% CI: -0.051, -0.004). No associations were observed with the overall low-grade @entity3 score. Further food component analyses indicated that consumption of more lean fish (per 100 g/wk) and raw vegetables (per 100 g/d), and fewer high-fat dairy products (per 100 g/d) was associated with less @entity7 [(b: -0.038; 95% CI: -0.072, -0.005), (b: -0.095; 95% CI: -0.191, 0.000), and (b: -0.070; 95% CI: -0.131, -0.009), respectively]. Consumption of more fresh fruit (per 100 g/d), wine (per 100 mL/wk), and poultry (per 100 g/d), and fewer high-fat dairy products (per 100 g/d) was associated with less low-grade @entity3 [(b: -0.074; 95% CI: -0.133, -0.015), (b:-0.006; 95% CI: -0.013, 0.001), (b:-0.247; 95% CI: -0.479, -0.014), and (b:-0.100; 95% CI: -0.182, -0.019), respectively]. CONCLUSION: These data suggest that the dietary modification of @entity7 and low-grade @entity3 , processes that are important in atherothrombosis, is possible.

title: A Healthy Diet Is Associated with Less Endothelial Dysfunction and Less @entity3 over a 7-Year Period in Adults at Risk of XXXX .

answer: @entity5


abstract: BACKGROUND: A healthy diet rich in fish, fruit, and vegetables, but moderate in @entity6 and low in dairy products and meat, has been associated with a lower rate of incident @entity5 ( @entity5 ). The underlying mechanisms, however, remain unclear. @entity7 and low-grade @entity3 play important roles in @entity5 . A healthy diet might modify these phenomena. OBJECTIVE: We investigated the associations between the above food groups and overall biomarker scores of @entity7 and low-grade @entity3 in a 7-y longitudinal study. METHODS: Using longitudinal data from 557 @entity0 at increased @entity5 risk from the CODAM (Cohort on @entity2 and @entity11 Maastricht) Study, we assessed diet intake by food-frequency questionnaire and measured plasma biomarkers of @entity7 [von Willebrand factor, soluble vascular cell adhesion molecule 1, soluble endothelial selectin, soluble thrombomodulin, soluble intercellular adhesion molecule 1 (sICAM-1)] and low-grade @entity3 [ @entity12 , serum amyloid A, @entity9 , @entity10 , @entity1 @entity4 factor a, and sICAM-1]. At baseline, @entity0 were aged 59.6    6.9 y. Measurements were performed then and after 7 y. Biomarkers were combined into overall scores (sum of z scores; higher scores indicating worse function). Longitudinal data were analyzed with generalized estimating equations and adjusted for sex, age, @entity8 metabolism, energy intake, body mass index, physical activity, @entity6 consumption, and smoking. RESULTS: Higher consumption of fish (per 100 g/wk), but not total consumption of vegetables, fruit, @entity6 -containing beverages, dairy products, or meat, was associated with a lower overall @entity7 score over 7 y (b: -0.027; 95% CI: -0.051, -0.004). No associations were observed with the overall low-grade @entity3 score. Further food component analyses indicated that consumption of more lean fish (per 100 g/wk) and raw vegetables (per 100 g/d), and fewer high-fat dairy products (per 100 g/d) was associated with less @entity7 [(b: -0.038; 95% CI: -0.072, -0.005), (b: -0.095; 95% CI: -0.191, 0.000), and (b: -0.070; 95% CI: -0.131, -0.009), respectively]. Consumption of more fresh fruit (per 100 g/d), wine (per 100 mL/wk), and poultry (per 100 g/d), and fewer high-fat dairy products (per 100 g/d) was associated with less low-grade @entity3 [(b: -0.074; 95% CI: -0.133, -0.015), (b:-0.006; 95% CI: -0.013, 0.001), (b:-0.247; 95% CI: -0.479, -0.014), and (b:-0.100; 95% CI: -0.182, -0.019), respectively]. CONCLUSION: These data suggest that the dietary modification of @entity7 and low-grade @entity3 , processes that are important in atherothrombosis, is possible.

title: A Healthy Diet Is Associated with Less Endothelial Dysfunction and Less XXXX over a 7-Year Period in Adults at Risk of @entity5 .

answer: @entity3


abstract: BACKGROUND: To assess the influence of visual acuity (VA) on suicidal ideation, suicide attempts and @entity2 . METHODS: From 2008 to 2012, a total of 28   919 nationally representative @entity0 aged 19   years or older in the Korea National Health and Nutrition Examination Survey underwent additional ophthalmological examinations by the Korean Ophthalmologic Society. Associations between best corrected VA in the better-seeing eye based on decimal fraction and mental health were identified using multivariable logistic regression analysis after adjusting for possible biopsychosocial confounders. Self-reported mental health (suicidal ideation, suicide attempt and @entity2 ), @entity3 Quality of Life-Visual Analog Scale and counselling experience were evaluated by direct interviews. A nomogram for risk of suicidal ideation was generated. RESULTS: By multivariable logistic regression analysis, low VA was significantly associated with suicidal ideation and suicide attempt but not @entity2 . @entity0 with a VA of no light perception to 0.2 had a nearly twofold and threefold increased risk of suicidal ideation (adjusted OR, 1.85; 95% CI 1.04 to 3.27) and suicidal attempt (adjusted OR, 3.44; 95% CI 0.92 to 12.79), compared with @entity0 with a VA of 1.0. Sociodemographic disparities, including age and socioeconomic status, existed for suicidal ideation, suicidal attempt and @entity2 . @entity3 Quality of Life-Visual Analog Scale significantly decreased as VA decreased and was lower in @entity0 who attempted suicide. CONCLUSIONS: Low VA was associated with the occurrence of suicidal ideation or a suicide attempt. Ophthalmologists should embrace their responsibility to help reduce suicidality and prevent suicides in @entity0 with low VA by encouraging them to seek @entity1 care.

title: Influence of visual acuity on suicidal ideation, suicide attempts and XXXX in South Korea.

answer: @entity2


abstract: Satellite cells were isolated from skeletal muscles of adult normal and dystrophic @entity1 (C57/6J/dy strain) by sequential digestion of tissue fragments with collagenase, hyaluronidase and trypsin. These cells exhibit in culture similar behaviour to that of @entity4 , undergoing an initial duplicative period lasting about 2--3 days, followed by a shorter phase (1--2 days) of rapid cell fusion. During the duplicative phase most of the satellite cells appear round-shaped, whereas @entity4 appear typically spindle-shaped: both cell types actively incorporate @entity2 . During the subsequent days of culture an increasing number of satellite cells becomes spindle-shaped; afterwards the cells contact each other and fuse into multinucleated myotubes. The majority of spindle-shaped satellite cells is unable to incorporate @entity2 , thus behaving as post-mitotic cells. Concomitantly with satellite cell fusion, an increase of about 80-fold of @entity3 phosphokinase (CPK) specific activity is observed. Satellite cells are able to recognize co-cultured @entity4 ( @entity2 -labelled): hybrid myotubes containing labelled and unlabelled nuclei are formed in these experimental conditions. Satellite cells from dystrophic animals are able to differentiate in culture and do not show appreciable differences as compared to their normal counterparts. In @entity5 , however, CPK specific activity is almost twice that observed in normal myotubes. @entity0 dystrophic satellite cells from biopsies of adult muscle cultured in similar conditions grow and fuse into multinucleated myotubes showing a behaviour identical to normal controls.

title: In vitro differentiation of satellite cells isolated from normal and dystrophic XXXX muscles. A comparison with embryonic myogenic cells.

answer: @entity0


abstract: UNASSIGNED: Neurochemical pathways involved in pathological @entity4 and @entity1 are poorly understood. Although previous studies have shown increased  -opioid receptor ( @entity3 ) and decreased @entity2 (D2R) availability in addictive disorders, the role that these systems play in @entity0 @entity1 still remains unclear. We studied 13 morbidly @entity1 @entity0 [mean body mass index (BMI), 42 kg/m(2)] and 14 nonobese age-matched @entity0 , and measured brain @entity3 and D2R availability using PET with selective radioligands [(11)C]carfentanil and [(11)C]raclopride, respectively. We also used quantitative meta-analytic techniques to pool previous evidence on the effects of @entity1 on altered D2R availability. Morbidly @entity1 subjects had significantly lower @entity3 availability than control subjects in brain regions relevant for reward processing, including ventral striatum, insula, and thalamus. Moreover, in these areas, BMI correlated negatively with @entity3 availability. Striatal @entity3 availability was also negatively associated with self-reported food addiction and restrained eating patterns. There were no significant differences in D2R availability between @entity1 and nonobese subjects in any brain region. Meta-analysis confirmed that current evidence for altered D2R availability in @entity1 is only modest. Obesity appears to have unique neurobiological underpinnings in the reward circuit, whereby it is more similar to opioid addiction than to other addictive disorders. The opioid system modulates motivation and reward processing, and low  -opioid availability may promote @entity4 to compensate decreased hedonic responses in this system. Behavioral and pharmacological strategies for recovering opioidergic function might thus be critical to curb the @entity1 epidemic.

title: Obesity Is Associated with Decreased  -Opioid But Unaltered XXXX Availability in the Brain.

answer: @entity2


abstract: UNASSIGNED: Autoimmune haemorrhaphilia XIII/13 (AH13) is an acquired life-threatening @entity3 due to anti-factor XIII (FXIII) autoantibodies (auto-Abs). AH13 @entity0 may die of @entity1 without correct diagnosis and proper treatment because of lack of awareness and the absence of rapid easy-to-use tests specific for this disease. Currently, the definitive diagnosis is established by cumbersome and time-consuming laboratory tests such as dot-blot assays and enzyme-linked immunosorbent assays (ELISA), and therefore these tests are generally not carried out. To save AH13 @entity0 ' lives, there is an urgent necessity for developing a rapid test for FXIII auto-Abs. We first generated and characterised mouse monoclonal antibodies (mAb) against @entity0 FXIII A subunit (FXIII-A), and then developed a rapid @entity2 ( @entity2 ) for detection of anti-FXIII-A auto-Abs using one mAb with a dissociation constant of 9.3 * 10        M. The auto-Ab-FXIII-A complex was captured by the mAb on a nitrocellulose membrane and visualised by Au-conjugated anti-human IgG Ab. Mixing with healthy control plasma improved the detection of auto-Abs in @entity0 having extremely low levels of FXIII-A. The specificity and sensitivity of the @entity2 were 87   % and 94   %, respectively. We also detected auto-Abs against activated FXIII (FXIIIa) in three @entity0 by pre-converting FXIII to FXIIIa by thrombin treatment. @entity2 values were significantly inversely correlated with FXIII activity levels, indicating an association between the quantity of anti-FXIII autoantibodies and AH13. This reliable rapid @entity2 assay can be applied to a point-of-care test to detect anti-FXIII-A auto-Abs, and will contribute to early diagnosis and treatment of AH13.

title: Rapid XXXX for detection of anti-factor XIII A subunit antibodies can diagnose 90   % of cases with autoimmune haemorrhaphilia XIII/13.

answer: @entity2


abstract: OBJECTIVES: Imaging of the brachial plexus has come a long way and has progressed from plain radiography to CT and CT myelography to MRI. Evolution of MR imaging sequences has enabled good visualization of the small components of the plexus. The purpose of our study was to correlate the results of MR neurography (MRN) in @entity0 with traumatic @entity1 with their operative findings. We wanted to determine the usefulness of MRN and how it influenced surgical planning and outcome. METHODS: Twenty @entity0 with features of traumatic @entity1 who were referred to the MRI section of the Department of Radiology between September 2012 and January 2014 and subsequently underwent exploration were included in the study. MR neurography and operative findings were recorded at three levels of the brachial plexus-roots, trunks and cords. RESULTS: Findings at the level of roots and trunks were noted in 14 @entity0 each and at the level of the cords in 16 @entity0 . 10 @entity0 had involvement at all levels. Axillary nerve involvement as a solitary finding was noted in two @entity0 . These @entity0 were subsequently operated and their studies were assigned a score based on the feedback from the operating surgeons. The MRN study was scored as three (good), two (average) or one (poor) depending on whether the MR findings correlated with operative findings at all three levels, any two levels or at any one level, respectively. CONCLUSIONS: MR neurography is an extremely useful modality to image the traumatized brachial plexus. It influences both surgical planning and outcome/prognosis.

title: MR neurography in traumatic XXXX .

answer: @entity1


abstract: Most eye problems referred to vascular surgeons for workup of @entity2 are either transient ( @entity6 fugax) or partial (retinal branch @entity4 ) @entity3 . @entity0 with more severe total infarcts of the retina (central retinal @entity4 ) or of the head of the optic nerve (" @entity5 ") are seldom suspected of @entity2 and, in the latter case, are generally labeled idiopathic. An explanation for the difference in attitude towards these conditions is suggested. A prescribed carotid etiology for these various @entity9 was explored in a study of 20 consecutive @entity0 who had @entity9 . Special visualization of the neck, orbital, and retinal vasculature was obtained. Sixty percent had ipsilateral and 50% had contralateral @entity7 . The ophthalmic artery and the posterior ciliary arteries showed intrinsic lesions each in 25% of cases. Our pilot study concludes that there is strong evidence that most of these @entity1 are related to @entity7 , which is found in the majority of @entity0 . In a minority of them ischemic problems may be due to @entity8 or to intrinsic disease of the ophthalmic artery. A more cohesive approach to the study and treatment of these different entities is supported by the suggestion of a common etiology for most of them. Close collaboration with ophthalmologists will be needed to improve the present management of these eye conditions.

title: XXXX and their carotid origin.

answer: @entity9


abstract: PURPOSE: Selection of @entity0 for resection of synchronous liver metastases (LM) and @entity3 ( @entity3 ) of @entity1 ( @entity1 ) remains a debated issue since morbidity of this surgery is not negligible. We aimed to define @entity4 ( @entity4 ) prognostic criteria in @entity0 undergoing @entity3 surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) and LM resection. METHODS: This monocentric and comparative study included all consecutive @entity0 operated for LM (LM group, n  =  77), @entity3 (HIPEC group, n  =  18) and @entity3  +  LM (LM  +  HIPEC group, n  =  9) from January 2007 to May 2011. Characteristics of the 3 groups were prospectively collected and retrospectively compared. RESULTS: Median follow-up was 56,5 months. Major morbidity and mortality were respectively 14% and 3%. Two-year disease free and @entity4 rates were respectively 23% and 76%. There were significantly more Dindo grade III-IV complications in LM  +  HIPEC group. In multivariate analysis, grade II and III preoperative chemotherapy-induced @entity2 and size of LM were identified as poor @entity4 prognostic factors whereas response to preoperative chemotherapy significantly increases @entity4 . @entity4 was not different (p  =  0.235) between the 3 groups. CONCLUSION: @entity2 to preoperative chemotherapy and size of LM were identified as poor prognostic factors in @entity0 undergoing simultaneous @entity3 and LM surgery. These criteria could help in better selecting @entity0 for such extensive surgery.

title: XXXX with synchronous liver metastases from @entity1 : Who will benefit from complete cytoreductive surgery?

answer: @entity3


abstract: PURPOSE: Selection of @entity0 for resection of synchronous liver metastases (LM) and @entity3 ( @entity3 ) of @entity1 ( @entity1 ) remains a debated issue since morbidity of this surgery is not negligible. We aimed to define @entity4 ( @entity4 ) prognostic criteria in @entity0 undergoing @entity3 surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) and LM resection. METHODS: This monocentric and comparative study included all consecutive @entity0 operated for LM (LM group, n  =  77), @entity3 (HIPEC group, n  =  18) and @entity3  +  LM (LM  +  HIPEC group, n  =  9) from January 2007 to May 2011. Characteristics of the 3 groups were prospectively collected and retrospectively compared. RESULTS: Median follow-up was 56,5 months. Major morbidity and mortality were respectively 14% and 3%. Two-year disease free and @entity4 rates were respectively 23% and 76%. There were significantly more Dindo grade III-IV complications in LM  +  HIPEC group. In multivariate analysis, grade II and III preoperative chemotherapy-induced @entity2 and size of LM were identified as poor @entity4 prognostic factors whereas response to preoperative chemotherapy significantly increases @entity4 . @entity4 was not different (p  =  0.235) between the 3 groups. CONCLUSION: @entity2 to preoperative chemotherapy and size of LM were identified as poor prognostic factors in @entity0 undergoing simultaneous @entity3 and LM surgery. These criteria could help in better selecting @entity0 for such extensive surgery.

title: @entity3 with synchronous liver metastases from XXXX : Who will benefit from complete cytoreductive surgery?

answer: @entity1


abstract: @entity6 ( @entity6 ), also referred to as @entity4 , is the most common form of @entity3 in @entity5 , affecting tens of thousands of @entity5 worldwide each year. @entity5 @entity6 is usually a high grade invasive @entity1 . Problems associated with @entity6 include @entity7 , distant metastases in >50% of affected @entity5 , and clinical signs that are troubling both to the @entity5 and to their owners. Risk factors for @entity6 include exposure to older types of flea control products and lawn chemicals, @entity2 , female sex, and a very strong breed-associated risk. This knowledge is allowing pet owners to take steps to reduce the risk of @entity6 in their @entity5 . The diagnosis of @entity6 is made by histopathology of tissue biopsies obtained by cystoscopy, surgery, or catheter. Percutaneous aspirates and biopsies should be avoided due to the risk of @entity1 seeding. @entity6 is most commonly located in the trigone region of the bladder precluding complete surgical resection. Medical treatment is the mainstay for @entity6 therapy in @entity5 . Although @entity6 is not usually curable in @entity5 , multiple drugs have activity against it. Approximately 75% of @entity5 respond favorably to @entity6 treatment and can enjoy several months to a year or more of good quality life. Many promising new therapies for @entity6 are emerging and with the close similarity between @entity6 in @entity5 and high grade invasive @entity3 in @entity0 , new treatment strategies found to be successful in @entity5 studies are expected to help @entity5 and to be subsequently translated to @entity0 .

title: Management of transitional cell XXXX in @entity5 : a review.

answer: @entity3


abstract: @entity6 ( @entity6 ), also referred to as @entity4 , is the most common form of @entity3 in @entity5 , affecting tens of thousands of @entity5 worldwide each year. @entity5 @entity6 is usually a high grade invasive @entity1 . Problems associated with @entity6 include @entity7 , distant metastases in >50% of affected @entity5 , and clinical signs that are troubling both to the @entity5 and to their owners. Risk factors for @entity6 include exposure to older types of flea control products and lawn chemicals, @entity2 , female sex, and a very strong breed-associated risk. This knowledge is allowing pet owners to take steps to reduce the risk of @entity6 in their @entity5 . The diagnosis of @entity6 is made by histopathology of tissue biopsies obtained by cystoscopy, surgery, or catheter. Percutaneous aspirates and biopsies should be avoided due to the risk of @entity1 seeding. @entity6 is most commonly located in the trigone region of the bladder precluding complete surgical resection. Medical treatment is the mainstay for @entity6 therapy in @entity5 . Although @entity6 is not usually curable in @entity5 , multiple drugs have activity against it. Approximately 75% of @entity5 respond favorably to @entity6 treatment and can enjoy several months to a year or more of good quality life. Many promising new therapies for @entity6 are emerging and with the close similarity between @entity6 in @entity5 and high grade invasive @entity3 in @entity0 , new treatment strategies found to be successful in @entity5 studies are expected to help @entity5 and to be subsequently translated to @entity0 .

title: Management of transitional cell @entity3 in XXXX : a review.

answer: @entity5


abstract: AIM: To detect @entity5 ) in the esophageal mucosa and the possible relationship with @entity4 in Greece. METHODS: Forty-nine @entity0 underwent esophagogastroduodenoscopy (EGD) and esophageal biopsy at a university hospital that acts as a referral center for Northern Greece. Nineteen of these @entity0 (14 male and 5 female) had @entity7 ( @entity7 ) and 30 (15 male and 15 female) did not have any reported @entity1 . Histopathological assessment was followed by polymerase chain reaction analysis of all the samples. @entity0 demographic data (age, sex, and place of birth) and information regarding smoking habits, @entity2 consumption or sexual habits were collected. A method of statistical interference, verification of hypotheses based on homogeneity and independent   (2) test, was used. RESULTS: From the 49 @entity0 that underwent EGD and biopsy, 19 had @entity7 and 30 had normal esophageal mucosa, with a mean age of 65.2 years. Regarding the prevalence of oncogenic risk factors for @entity4 , an interesting conclusion was that 78% of the @entity0 used @entity3 and almost one-third had multiple sexual partners, whereas only 20% of the @entity0 consumed @entity2 , which was not statistically significant, when compared to the control group. In the @entity7 group, the only two positive samples were among the male @entity0 (2/14 male @entity0 with @entity7 , 14.5%). No HPV was identified in the control group. The predominant HPV types identified were 11 and 31, which have a low malignancy potential. The presence of HPV DNA in the @entity7 group was not statistically significant, 95% confidence interval (  2=3.292, P=0.07). CONCLUSION: This is the first relevant study in Greece, and despite the lack of statistical significance, the issue of @entity6 and @entity7 does merit further investigation.

title: Detection of XXXX DNA in @entity4 in Greece.

answer: @entity5


abstract: AIM: To detect @entity5 ) in the esophageal mucosa and the possible relationship with @entity4 in Greece. METHODS: Forty-nine @entity0 underwent esophagogastroduodenoscopy (EGD) and esophageal biopsy at a university hospital that acts as a referral center for Northern Greece. Nineteen of these @entity0 (14 male and 5 female) had @entity7 ( @entity7 ) and 30 (15 male and 15 female) did not have any reported @entity1 . Histopathological assessment was followed by polymerase chain reaction analysis of all the samples. @entity0 demographic data (age, sex, and place of birth) and information regarding smoking habits, @entity2 consumption or sexual habits were collected. A method of statistical interference, verification of hypotheses based on homogeneity and independent   (2) test, was used. RESULTS: From the 49 @entity0 that underwent EGD and biopsy, 19 had @entity7 and 30 had normal esophageal mucosa, with a mean age of 65.2 years. Regarding the prevalence of oncogenic risk factors for @entity4 , an interesting conclusion was that 78% of the @entity0 used @entity3 and almost one-third had multiple sexual partners, whereas only 20% of the @entity0 consumed @entity2 , which was not statistically significant, when compared to the control group. In the @entity7 group, the only two positive samples were among the male @entity0 (2/14 male @entity0 with @entity7 , 14.5%). No HPV was identified in the control group. The predominant HPV types identified were 11 and 31, which have a low malignancy potential. The presence of HPV DNA in the @entity7 group was not statistically significant, 95% confidence interval (  2=3.292, P=0.07). CONCLUSION: This is the first relevant study in Greece, and despite the lack of statistical significance, the issue of @entity6 and @entity7 does merit further investigation.

title: Detection of @entity5 DNA in XXXX in Greece.

answer: @entity4


abstract: BACKGROUND: The symmetrical Lyon brace is a brace, usually used to maintain correction after a plaster cast reduction in the Cotrel's EDF (Elongation-Derotation-Flexion) frame. The new Lyon brace or ARTbrace is an immediate corrective brace based on some of the principles of the plaster cast which are improved due to advances in CAD/ @entity2 technology. The aim of this paper is to describe concepts of this new brace to be not only a replacement of the plaster cast, but also a definitive brace. METHODS: Instead of a plaster cast, three segmental CAD/ @entity2 moulds are made with the instantaneous full 3D raster stereography digitizer (Orten):In self axial elongationIn shift and lumbar lordosisIn shift and thoracic kyphosis A specific software (OrtenShape) makes up the overlay of the three moulds. Mould 1 is used for the pelvis and the shoulders mould 2 for the lumbar segment and mould 3 for the thoracic segment. The mathematical basis of the ARTbrace is the torso column which is a circled helicoid with horizontal circle generator. A torso column is reproduced in the opposite direction of the @entity1 . Like the plaster cast, the ARTbrace is worn for a "total time" of 24  hours 7  days a week without modifying the standard protocol of the Lyon brace reduction. The prospective controlled cohort observational study of the 225 first @entity0 treated since May 2013 is reported below. RESULTS: The in-brace immediate reduction is: 0.7, i.e. 40% better with the ARTbrace than with a plaster cast. The correction of flat back is 9   (from 18  .4 to 28  .5 kyphosis Cobb angle). The improved aesthetic appearance is equal for rib hump and @entity3 . CONCLUSION: This first paper is an introduction with very short results and does not prejudge the final outcome. The ARTbrace can be used not only to replace the plaster cast, but also as a definitive brace. The new segmental moulding with final detorsion is even more efficient and to this day the ARTbrace is the most effective to reduce the Cobb angle of @entity1 .

title: Prospective study and new concepts based on XXXX detorsion of the first 225 early in-brace radiological results with the new Lyon brace: ARTbrace.

answer: @entity1


abstract: The BCR-ABL1-negative @entity1 ( @entity1 ) share an increased risk of @entity3 . Risk factors for @entity3 are less well defined than those for @entity4 . Because @entity0 with @entity7 mutations have higher platelet counts compared to @entity8 @entity9 -mutated @entity0 , @entity3 rates may be increased in this group. Our aim was to retrospectively evaluate whether @entity6 ( @entity6 ), @entity5 , mutational status, or treatment history are associated with @entity3 in a cohort of @entity1 @entity0 . Using an electronic database, @entity1 @entity0 seen between 2005 and 2013 were retrospectively identified using ICD-9 codes and billing records. A @entity3 event was defined as one that was identified in the medical record and graded based on the Common Terminology Criteria for Adverse Event (CTCAE) version 4.0. Among 351 @entity1 @entity0 , 15.6 % experienced 64 @entity3 event types. There was no association of @entity3 with mutational status, gender, @entity1 subtype, @entity2 use, prior @entity4 , or platelet count at presentation. There was an association between @entity3 and older age at diagnosis. aVWD was identified in six @entity0 . In this single-center retrospective study, @entity3 events were identified in 15 % of @entity0 , and associated with older age at diagnosis. aVWD was rarely tested for in this cohort.

title: Bleeding complications in BCR-ABL negative XXXX : prevalence, type, and risk factors in a single-center cohort.

answer: @entity1


abstract: UNASSIGNED: The objective of this study was to describe the epidemiological, clinical, therapeutic and prognostic aspects of the @entity4 in the obstetrics and gynecology department at the University Teaching Hospital Yalgado Ouedraogo of Ouagadougou. It has been a descriptive crosssectional study over a period of 12 months from 1 April 2013 to 31 March 2014. The main criterion for inclusion in our sample was the occurrence of @entity1 in a pregnant more than 20 weeks of gestation or recently delivered with elevation of blood pressure and the presence of albumin in the urine. The @entity0 were followed from the onset of the crisis until hospital discharge. Data were collected and analyzed using Epi Info 3.5.1. The significance level of 5% was used for data comparison. We identified 203 cases of @entity4 for 6063 deliveries that to say a frequency of 3.3%. The average age of @entity0 was 27.5 years [14-46]. In socio-demographic terms, @entity0 were housewives in 62.5% of cases, the average rate of the past-deliver number was 4.2 [0-11] and 47.7% of @entity0 were living as married. Clinically, they were referred in 72.4% of cases and were initially admitted into the service for elevation of blood pressure in 40.3% of cases. The mean gestational age was 31.5 weeks [23-41]; diastolic blood pressure exceeded 110 mmHg in 63.1% of cases. Therapeutically, all the @entity0 benefited from a treatment based in anticonvulsant by @entity3 and antihypertensive therapy by @entity5 , @entity2 or @entity6 . Maternal prognosis was marked by significant morbidity in 46 cases (22.6%) and mortality in 13 @entity0 that to say a fatality rate of 6.4%. The fetal one was dominated by a perinatal lethality in 31.5% of the cases. @entity4 is a major cause of maternal and perinatal mortality in the University Teaching Hospital of Ouagadougou. The adoption of strategies for screening during antenatal consultations and early management should contribute to the reduction of the mortality in the mother and @entity0 couple in Burkina Faso.

title: [ XXXX at the University hospital Yalgado of Ouagadougou (Burkina Faso) from 1 April 2013 to 31 March 2014].

answer: @entity4


abstract: BACKGROUND: Between 20 and 30 bacteriologically confirmed cases of @entity1 are diagnosed each year at the French National Reference Center for mycobacteria. @entity0 are mainly immigrants from various endemic countries or living in French overseas territories. We aimed at expanding data regarding the geographical distribution of the SNP genotypes of the @entity3 isolates from these @entity0 . METHODOLOGY/PRINCIPAL FINDINGS: Skin biopsies were obtained from 71 @entity1 @entity0 diagnosed between January 2009 and December 2013. Data regarding age, sex and place of birth and residence were also collected. Diagnosis of @entity1 was confirmed by microscopic detection of acid-fast bacilli and/or amplification by PCR of the @entity3 -specific RLEP region. Single nucleotide polymorphisms (SNP), present in the @entity3 genome at positions 14 676, 1 642 875 and 2 935 685, were determined with an efficiency of 94% (67/71). Almost all @entity0 were from countries other than France where @entity1 is still prevalent (n = 31) or from French overseas territories (n = 36) where @entity1 is not totally eradicated, while only a minority (n = 4) was born in metropolitan France but have lived in other countries. SNP type 1 was predominant (n = 33), followed by type 3 (n = 17), type 4 (n = 11) and type 2 (n = 6). SNP types were concordant with those previously reported as prevalent in the @entity0 ' countries of birth. SNP types found in @entity0 born in countries other than France (Comoros, Haiti, Benin, Congo, @entity2 Lanka) and French overseas territories (French Polynesia, Mayotte and La R  union) not covered by previous work correlated well with geographical location and history of @entity0 settlements. CONCLUSIONS/SIGNIFICANCE: The phylogenic analysis of @entity3 strains isolated in France strongly suggests that French @entity1 cases are caused by SNP types that are (a) concordant with the geographic origin or residence of the @entity0 (non-French countries, French overseas territories, metropolitan France) or (b) more likely random in regions where diverse migration flows occurred.

title: New Insights into the Geographic Distribution of XXXX SNP Genotypes Determined for Isolates from Leprosy Cases Diagnosed in Metropolitan France and French Territories.

answer: @entity3


abstract: Objective @entity3 ( @entity3 ) @entity0 have an increased cardiovascular burden. In this study, we aimed to compare certain @entity3 solutions (Physioneal(  ) and Dianeal(  )) in terms of the ambulatory blood pressure, echocardiographic parameters (ECHO), @entity5 , endothelial function and serum asymmetric dimethylarginine (ADMA) level. Methods A total of 45 @entity3 @entity0 were enrolled in this prospective randomized controlled study: 23 @entity0 in the Dianeal(  ) group and 22 @entity0 in the Physioneal(  ) group. Ambulatory blood pressure measurements, echocardiography, carotid artery intima-media thickness measurements and @entity4 ( @entity4 ) and ADMA values were obtained at baseline and 12 months. Results The baseline parameters were similar between the groups with respect to the echocardiographic parameters, 24-hour ambulatory blood monitoring measurements and ADMA and @entity4 levels. All 24-hour blood pressure monitoring measurements, except for the average daytime systolic blood pressure, were significantly decreased in both groups at the first year. In the Physioneal(  ) group, a significant decrease was observed with regard to the ADMA levels. Considering the @entity4 values, significant augmentation was seen at the end of the first year in both groups. Improvements in the @entity4 measurements were prominent in the Physioneal(  ) group; however, this finding was not statistically significant. Conclusion The use of solutions with a neutral pH in @entity3 @entity0 results in decreased ADMA levels, which may be an important contributor to reductions in the incidence of @entity1 and @entity2 in this population.

title: Effects of dialysis solution on the cardiovascular function in peritoneal dialysis XXXX .

answer: @entity0


abstract: UNASSIGNED: Nuclear polarity is characterized by intracytoplasmic nuclear positioning and alignment in the tissue. The mechanisms responsible for maintaining nuclear polarity in normal cells and its disturbance in neoplastic cells are not understood. We studied microtubule-organizing center (MTOC) positioning-mediated nuclear polarity in various normal and neoplastic @entity0 tissues, as well as in cultured cells. To visualize the MTOC in cells, gamma-tubulin and @entity2 were immunohistochemically stained by fluorescence and non-fluorescence methods. Position of MTOC in normal and neoplastic tissue was assessed by spatial relationship with nucleus and apico-basal axis. We found MTOC positioning to be related to morphogenesis in various normal and neoplastic @entity0 tissues, as well as in cultured cells. MTOC positions were different between two-dimensional cultured isolated cells and three-dimensional cultured gland-formed cells. The MTOC position was specific depending on the cell type in the tissue structure. In particular, glandular and urothelial epithelium had a strong relationship with preservation of nuclear polarity and MTOC positioning. @entity1 cells showed an irregular position or absence of the MTOC depending on poorer differentiation and higher grade of @entity1 . In conclusion, the position of the MTOC affects regulation of nuclear polarity and morphogenesis of normal and pathological tissue structure.

title: Microtubule-organizing center-mediated nuclear polarity in various normal and neoplastic XXXX tissues.

answer: @entity0


abstract: We investigated whether glomerular hemodynamic parameters in nondiabetic subjects, including healthy subjects, are associated with glycemic status indices, by simultaneous measurement of inulin ( @entity4 ) and para-aminohippuric acid (CPHA) clearance. Twenty-six subjects (age 49.5      13.3  years; 13 @entity0 and 13 @entity0 ; 14 healthy subjects and 12 subjects with mild @entity2 ) were enrolled. @entity4 and @entity3 were measured simultaneously. All 26 subjects were nondiabetics. Estimated preglomerular resistance, estimated postglomerular resistance, and estimated glomerular hydrostatic pressure (Pglo) were calculated according to Gomez' formula. Pglo correlated significantly and positively with hemoglobin A1c (HbA1c) in both healthy subjects (r  =  0.532, P  =  0.0498) and subjects with mild @entity2 (r  =  0.681, P  =  0.015). While there was no significant correlation between estimated preglomerular resistance and HbA1c, estimated postglomerular resistance correlated significantly and positively with HbA1c both in healthy subjects (r  =  0.643, P  =  0.013) and subjects with mild @entity2 (r  =  0.589, P  =  0.044). Glomerular filtration fraction, estimated Pglo and estimated postglomerular resistance in total subjects were associated significantly with HbA1c after adjustment for age, gender, and body mass index. These results demonstrate that, even in nondiabetic subjects, glycemic status is associated with estimated postglomerular resistance, but not estimated preglomerular resistance. It is suggested that increased estimated postglomerular resistance associated with higher HbA1c levels, even within the normal range, causes increased estimated Pglo, leading to increased FF. Thus, hemodynamic abnormalities associated with higher HbA1c levels may be related to glomerular @entity1 , even in nondiabetic subjects.

title: Significant association between glycemic status and increased estimated postglomerular resistance in nondiabetic subjects - study of inulin and para-aminohippuric acid clearance in XXXX .

answer: @entity0


abstract: The objective of the present study was to isolate, identify and characterize new LAB strains with high probiotic potentials from Iranian (Isfahan) indigenous @entity2 . From 90 isolated LABs, 11 isolates had high growth rate under different stress conditions, including acid (pH 2.5), bile (0.5% oxgall), salt (6-15%) and temperatures 15 and 45  C, and their aggregation time was less than 120 min. Based on the molecular identification using 16S rDNA sequencing and phylogenetic analysis, the isolates belonged to two @entity5 and @entity3 species. The isolates showed different tolerance to 16 clinically and veterinary relevant antibiotics, and most of them were resistant to or semi-tolerant of 7-15 different studied antibiotics. The Es11, Es12, Es3 and Es13 strains with resistance to or semi-tolerance of 15, 14 and 13 different antibiotics, respectively, were the most tolerant strains. The selected isolates showed a wide range of antimicrobial activity against 7 different pathogenic strains. All the isolates exhibited antagonistic activity against @entity0 , @entity6 , @entity4 and @entity1 . The isolates Es6 and Es11 with high antagonistic activity and resistance against 6 of the studied pathogens were the most powerful antagonistic isolates. The values and types of adhesion to the Caco-2 cell cultures were significantly different (0-40 bacteria/Caco-2 cell), and the maximum adhesion was observed for the isolates Es6 and Es13 with 35 and 40 bacteria adhesion/cell, respectively. Finally, based on all the experiments, 7 strains, including Es1, Es6, Es7, Es11, Es12 and Es13, were selected for the further in vivo assays and possible use in the poultry industry.

title: Characterization of some potentially probiotic XXXX strains isolated from Iranian native @entity2 .

answer: @entity3


abstract: The objective of the present study was to isolate, identify and characterize new LAB strains with high probiotic potentials from Iranian (Isfahan) indigenous @entity2 . From 90 isolated LABs, 11 isolates had high growth rate under different stress conditions, including acid (pH 2.5), bile (0.5% oxgall), salt (6-15%) and temperatures 15 and 45  C, and their aggregation time was less than 120 min. Based on the molecular identification using 16S rDNA sequencing and phylogenetic analysis, the isolates belonged to two @entity5 and @entity3 species. The isolates showed different tolerance to 16 clinically and veterinary relevant antibiotics, and most of them were resistant to or semi-tolerant of 7-15 different studied antibiotics. The Es11, Es12, Es3 and Es13 strains with resistance to or semi-tolerance of 15, 14 and 13 different antibiotics, respectively, were the most tolerant strains. The selected isolates showed a wide range of antimicrobial activity against 7 different pathogenic strains. All the isolates exhibited antagonistic activity against @entity0 , @entity6 , @entity4 and @entity1 . The isolates Es6 and Es11 with high antagonistic activity and resistance against 6 of the studied pathogens were the most powerful antagonistic isolates. The values and types of adhesion to the Caco-2 cell cultures were significantly different (0-40 bacteria/Caco-2 cell), and the maximum adhesion was observed for the isolates Es6 and Es13 with 35 and 40 bacteria adhesion/cell, respectively. Finally, based on all the experiments, 7 strains, including Es1, Es6, Es7, Es11, Es12 and Es13, were selected for the further in vivo assays and possible use in the poultry industry.

title: Characterization of some potentially probiotic @entity3 strains isolated from Iranian native XXXX .

answer: @entity2


abstract: OBJECTIVE: Although menstrual cycle length is one of the main concerns of @entity0 and may have important health consequences, little is known about its predictors. The aim of this study was to identify predictors of menstrual cycle length variability in healthy @entity0 . DESIGN: Prospective cross-sectional study. @entity0 : 200 healthy @entity0 aged 21-45. MEASUREMENTS: A questionnaire was administered to determine lifestyle factors. Ovarian parameters, metabolic parameters, pituitary hormones, sex @entity1 , and anti- m  llerian hormone ( @entity2 ) were measured. RESULTS: @entity0 with long (>= 35 days) and normal (25-34 days) menstrual cycles had >5-fold and >2-fold higher serum @entity2 levels, respectively, compared to those with short cycles (<25 days). Menstrual cycle length was associated with age but not lifestyle factors. Only one factor group (- @entity2 , antral follicle count [AFC], ovarian volume, testosterone and LH) was significantly associated with menstrual cycle length. Within this factor group, only the ovarian parameters ( @entity2 , AFC, ovarian volume) predicted menstrual cycle length. Each SD increase in @entity2 (32.9 pmol/L) and ovarian volume (2.29 cm(3) ) was associated with 2.80-fold (95% CI: 1.67-4.69) and 1.62-fold (95% CI: 1.08-2.43) increased risks, respectively, for longer menstrual cycles. CONCLUSIONS: @entity2 , AFC, and ovarian volume are positively associated with menstrual cycle length in healthy @entity0 . Our identification of @entity2 as an independent predictor of menstrual cycle length puts forth a new notion of utilizing menstrual cycle length to predict possible @entity2 -dependent/associated outcomes. In addition, this novel relationship may facilitate the interpretation of @entity2 levels and its clinico-pathological significance across different centres. This article is protected by copyright. All rights reserved.

title: Anti-m  llerian hormone, antral follicle count and ovarian volume predict menstrual cycle length in healthy XXXX .

answer: @entity0


abstract: @entity7 is a rare @entity2 with a poor prognosis. Compared to @entity5 , its molecular features are poorly known. We studied a total of 11 @entity7 , including 3 by exome and 4 by target sequencing. Exome sequencing revealed 65 nonsynonymous mutations and 22 indels with a mutation rate of 3.4 mutations/Mb per @entity2 , on average. By accounting for not only somatic but also germline mutations with loss of the wild-type allele, we identified recurrent mutations of @entity6 and FAT genes. @entity6 showed somatic or germline premature termination mutations, with loss of the wild-type allele in 3 of 7 @entity2 . @entity8 , @entity9 , and @entity10 showed somatic or germline missense mutations in 4 of 7 @entity2 . The germline FAT mutations were with loss of the wild-type allele. Loss of @entity6 expression was observed in 5 of 11 @entity2 . One @entity0 with a @entity6 -mutated @entity2 experienced complete remission of liver @entity1 following @entity4 chemotherapy. In conclusion, @entity7 show a distinct mutation pattern and often harbor somatic or germline mutations of @entity6 and FAT genes. This result may warrant assessment of @entity6 abrogation in @entity0 with the @entity3 to determine their sensitivity to chemotherapy.

title: Whole exome sequencing reveals recurrent mutations in @entity6 and FAT genes in XXXX of the pancreas.

answer: @entity7


abstract: @entity7 is a rare @entity2 with a poor prognosis. Compared to @entity5 , its molecular features are poorly known. We studied a total of 11 @entity7 , including 3 by exome and 4 by target sequencing. Exome sequencing revealed 65 nonsynonymous mutations and 22 indels with a mutation rate of 3.4 mutations/Mb per @entity2 , on average. By accounting for not only somatic but also germline mutations with loss of the wild-type allele, we identified recurrent mutations of @entity6 and FAT genes. @entity6 showed somatic or germline premature termination mutations, with loss of the wild-type allele in 3 of 7 @entity2 . @entity8 , @entity9 , and @entity10 showed somatic or germline missense mutations in 4 of 7 @entity2 . The germline FAT mutations were with loss of the wild-type allele. Loss of @entity6 expression was observed in 5 of 11 @entity2 . One @entity0 with a @entity6 -mutated @entity2 experienced complete remission of liver @entity1 following @entity4 chemotherapy. In conclusion, @entity7 show a distinct mutation pattern and often harbor somatic or germline mutations of @entity6 and FAT genes. This result may warrant assessment of @entity6 abrogation in @entity0 with the @entity3 to determine their sensitivity to chemotherapy.

title: Whole exome sequencing reveals recurrent mutations in XXXX and FAT genes in @entity7 of the pancreas.

answer: @entity6


abstract: PURPOSE: Standard magnetic resonance imaging (MRI) rarely identifies the cause of @entity3 in @entity0 with an angiogram-negative, non-perimesencephalic @entity2 ( @entity2 ). Yet up to 10   % of these @entity0 have recurrent @entity3 . The aim of the study was to explore the potential role of high-resolution contrast-enhanced 3-Tesla vessel wall-MRI in @entity0 with angiogram-negative @entity2 . METHODS: We performed intracranial vessel wall-MRI of the circle of Willis using a 3-Tesla scanner in consecutive @entity0 presenting with a spontaneous, angiogram-negative, non-perimesencephalic @entity2 . Vessel wall-MRI included T1-, T2-, and @entity5 -enhanced T1-weighted two-dimensional black-blood sequences in multiple planes (voxel size 0.4   *   0.4   *   2.0  mm). Two neuroradiologists independently scored abnormalities of the arterial wall. RESULTS: In all, 11 @entity0 (mean age 59 years) underwent vessel wall-MRI. A total of seven @entity0 had vessel wall abnormalities despite normal catheter angiography. Two @entity0 had focal abnormalities contiguous with the outer margin of the basilar artery wall for which we considered a differential of ruptured @entity1 , @entity1 , and loculated extramural blood from elsewhere. Two @entity0 had arterial wall enhancement involving multiple arteries, possibly secondary to @entity2 . Three @entity0 had arterial wall enhancement at sites of dural penetration, remote from the @entity2 , likely related to age and @entity4 risk factors. Vessel wall-MRI did not alter @entity0 management in this cohort. CONCLUSION: Vessel wall-MRI showed abnormalities in seven @entity0 with angiogram-negative @entity2 . These findings did not alter @entity0 management, but the findings may be useful for other physicians who choose to perform vessel wall-MRI in this @entity0 population.

title: High-Resolution Vessel Wall Magnetic Resonance Imaging in Angiogram-Negative Non-Perimesencephalic XXXX .

answer: @entity2


abstract: INTRODUCTION: Doctors who are diagnosed with @entity0 form a small subset of @entity1 with unique insight into their disease. The aim of this study was to compare key treatment decisions in medically-qualified doctors with equivalent degree-educated, matched controls diagnosed with early @entity0 . METHODS: @entity1 diagnosed with @entity0 between 01/01/2006 and 31/12/2011 were included and screened for occupation by 2 independent investigators. Allied health professionals with a medical background (e.g. nurses, physiotherapists) were excluded. @entity1 controls were matched by age, nodal status and grade. If there were more than 5 possible matches then those @entity1 with the closest @entity2 size were selected. RESULTS: 5259 of 8623 @entity1 had signed the generic research consent form. 619 of these were either doctors, or had received tertiary level education and could form appropriate controls. After exclusions, 46 medically-qualified doctors and 230 matched control @entity1 were included in the analysis. No statistical differences in age or @entity2 characteristics were identified between doctors with @entity0 and matched controls. No differences were identified between the two groups in the uptake of mastectomy, chemotherapy, immediate breast reconstruction or post-mastectomy radiotherapy. CONCLUSION: Medically-qualified @entity1 diagnosed with early @entity0 are no more likely to opt for mastectomy, chemotherapy, immediate breast reconstruction or post-mastectomy radiotherapy than non-medically-qualified controls. The level of information generally provided to @entity1 with @entity0 is adequate for a similar decision to be made by control @entity1 with equivalent levels of education, independent of any knowledge of pathology or understanding of the medical system that medically-qualified @entity1 may possess.

title: A case-control study of treatment choices made by doctors diagnosed with early XXXX .

answer: @entity0