abstract: PURPOSE: The aim of this study is to report and quantify the associated factors for morbidity and mortality following surgical management of cervical @entity4 (CSM). METHODS: The Nationwide Inpatient Sample (NIS) database was use to retrospectively review all @entity0 over 25  years of age with a diagnosis of CSM who underwent anterior and/or posterior cervical fusion or laminoplasty between 2001 and 2010. The main outcome measures were total procedure-related complications and mortality. Multivariate regression analysis was used to identify demographic, comorbidity, and surgical parameters associated with increased morbidity and mortality risk [reported as: OR (95  % CI)]. RESULTS: A total of 54,348 @entity0 underwent surgical intervention for CSM with an overall morbidity rate of 9.83  % and mortality rate of 0.43  %. Comorbidities found to be associated with an increased complication rate included: pulmonary circulation disorders [6.92 (5.91-8.12)], pathologic @entity3 [3.42 (3.00-3.90)], and electrolyte imbalance [2.82 (2.65-3.01)]. Comorbidities found to be associated with an increased mortality rate included: @entity5 [4.59 (3.62-5.82)], pulmonary circulation disorders [11.29 (8.24-15.47)], and pathologic @entity3 [5.43 (4.07-7.26)]. Alternatively, @entity2 [0.56 (0.46-0.67)] and @entity1 [0.36 (0.22-0.61)] were found to confer a decreased risk of mortality. Increased morbidity and mortality rates were also identified for fusions of 4-8 levels [morbidity: 1.55 (1.48-1.62), mortality: 1.80 (1.48-2.18)] and for age >65  years [morbidity: 1.65 (1.57-1.72), mortality: 2.74 (2.25-3.34)]. An increased morbidity rate was found for posterior-only [1.55 (1.47-1.63)] and combined anterior and posterior fusions [3.20 (2.98-3.43)], and an increased mortality rate was identified for posterior-only fusions [1.87 (1.40-2.49)]. Although revision fusions were associated with an increased morbidity rate [1.81 (1.64-2.00)], they were associated with a decreased rate of mortality [0.24 (0.10-0.59)]. CONCLUSION: The NIS database was used to provide national estimates of morbidity and mortality following surgical management of CSM in the United States. Several comorbidities, as well as @entity6 , were identified as associated factors.

title: Predictors of morbidity and mortality among @entity0 with cervical XXXX treated surgically.

answer: @entity4


abstract: PURPOSE: The aim of this study is to report and quantify the associated factors for morbidity and mortality following surgical management of cervical @entity4 (CSM). METHODS: The Nationwide Inpatient Sample (NIS) database was use to retrospectively review all @entity0 over 25  years of age with a diagnosis of CSM who underwent anterior and/or posterior cervical fusion or laminoplasty between 2001 and 2010. The main outcome measures were total procedure-related complications and mortality. Multivariate regression analysis was used to identify demographic, comorbidity, and surgical parameters associated with increased morbidity and mortality risk [reported as: OR (95  % CI)]. RESULTS: A total of 54,348 @entity0 underwent surgical intervention for CSM with an overall morbidity rate of 9.83  % and mortality rate of 0.43  %. Comorbidities found to be associated with an increased complication rate included: pulmonary circulation disorders [6.92 (5.91-8.12)], pathologic @entity3 [3.42 (3.00-3.90)], and electrolyte imbalance [2.82 (2.65-3.01)]. Comorbidities found to be associated with an increased mortality rate included: @entity5 [4.59 (3.62-5.82)], pulmonary circulation disorders [11.29 (8.24-15.47)], and pathologic @entity3 [5.43 (4.07-7.26)]. Alternatively, @entity2 [0.56 (0.46-0.67)] and @entity1 [0.36 (0.22-0.61)] were found to confer a decreased risk of mortality. Increased morbidity and mortality rates were also identified for fusions of 4-8 levels [morbidity: 1.55 (1.48-1.62), mortality: 1.80 (1.48-2.18)] and for age >65  years [morbidity: 1.65 (1.57-1.72), mortality: 2.74 (2.25-3.34)]. An increased morbidity rate was found for posterior-only [1.55 (1.47-1.63)] and combined anterior and posterior fusions [3.20 (2.98-3.43)], and an increased mortality rate was identified for posterior-only fusions [1.87 (1.40-2.49)]. Although revision fusions were associated with an increased morbidity rate [1.81 (1.64-2.00)], they were associated with a decreased rate of mortality [0.24 (0.10-0.59)]. CONCLUSION: The NIS database was used to provide national estimates of morbidity and mortality following surgical management of CSM in the United States. Several comorbidities, as well as @entity6 , were identified as associated factors.

title: Predictors of morbidity and mortality among XXXX with cervical @entity4 treated surgically.

answer: @entity0


abstract: BACKGROUND: Recent findings from clinical trials have indicated inconsistent associations between angiotensin II receptor blockers and the risk of @entity1 incidence. Furthermore, the relationship between antihypertensive drugs and @entity4 in @entity2 @entity0 remains unclear. METHODS: From Taiwan's national health insurance database, we identified 80,299 @entity0 diagnosed with @entity2 in 2001 and matched with 321,916 subjects without @entity2 by age, income, urbanization level, and index day. A total of 684 @entity2 patients without antihypertensive drug use (drug non-user subcohort) were also matched (1:4) with 2736 patients on antihypertensive medication (drug subcohort) using the same criteria. Each subject in the two study groups was followed up for a maximum of nine years, during which @entity3 was considered a competing event when performing the stratified Fine and Gray regression hazards model for the estimation of @entity4 risk for the cohorts. Uptake of antihypertensive prescription was considered a time-dependent variable. RESULTS: Our findings indicate that @entity0 with @entity2 are at significantly increased risk for @entity4 incidence when compared to their matched non- @entity2 counterparts (sHR=6.80, 95% CI=1.97-23.44, p=0.0024). Among @entity2 @entity0 , those with long term antihypertensive drug use are not at elevated risk of developing @entity4 relative to non-users of antihypertensive drugs (1-5year vs. non-user sHR=0.99, 95% CI=0.32-3.05; >5year vs. non-user sHR=0.88, 95% CI=0.34-2.26). CONCLUSIONS: @entity2 is considered a risk factor for @entity4 . However, long term uptake of antihypertensive medication in male @entity2 @entity0 should not be a concern for the development of @entity4 .

title: Long term antihypertensive drug use and XXXX risk: A 9-year population-based cohort analysis.

answer: @entity4


abstract: UNASSIGNED: High frequency of @entity5 is found in postmenopausal @entity0 where several molecular components were identified to be involved in @entity7 that subsequently leads to an increased @entity6 risk. @entity7 has already been determined in male @entity1 with @entity2 of muscarinic @entity8 receptor M3 (M3R-KO). Here we asked whether bone properties of female 16-week old M3R-KO present similarities to osteoporotic @entity7 by means of biomechanical, radiological, electron microscopic, cell- and molecular biological methods. Reduced biomechanical strength of M3R-KO correlated with cortical thickness and decreased @entity3 ( @entity3 ). Femur and vertebrae of M3R-KO demonstrated a declined trabecular bone volume, surface, and a higher trabecular pattern factor and structure model index (SMI) compared to @entity4 ( @entity4 ) @entity1 . In M3R-KO, the number of osteoclasts as well as the @entity10 mRNA expression was increased. Osteoclasts of M3R-KO showed an estimated increase in cytoplasmic vesicles. Further, histomorphometrical analysis revealed up-regulation of alkaline phosphatase. Osteoblasts and osteocytes showed a swollen cytoplasm with an estimated increase in the amount of rough endoplasmatic reticulum and in case of osteocytes a reduced pericellular space. Thus, current results on bone properties of 16-week old female M3R-KO are related to @entity9 phenotype. Stimulation and up-regulation of muscarinic @entity8 receptor subtype M3 expression in osteoblasts might be a possible new option for prevention and therapy of @entity9 . Pharmacological interventions and the risk of side effects have to be determined in upcoming studies.

title: Altered ultrastructure, density and XXXX expression in bone of female muscarinic @entity8 receptor M3 knockout @entity1 .

answer: @entity10


abstract: UNASSIGNED: High frequency of @entity5 is found in postmenopausal @entity0 where several molecular components were identified to be involved in @entity7 that subsequently leads to an increased @entity6 risk. @entity7 has already been determined in male @entity1 with @entity2 of muscarinic @entity8 receptor M3 (M3R-KO). Here we asked whether bone properties of female 16-week old M3R-KO present similarities to osteoporotic @entity7 by means of biomechanical, radiological, electron microscopic, cell- and molecular biological methods. Reduced biomechanical strength of M3R-KO correlated with cortical thickness and decreased @entity3 ( @entity3 ). Femur and vertebrae of M3R-KO demonstrated a declined trabecular bone volume, surface, and a higher trabecular pattern factor and structure model index (SMI) compared to @entity4 ( @entity4 ) @entity1 . In M3R-KO, the number of osteoclasts as well as the @entity10 mRNA expression was increased. Osteoclasts of M3R-KO showed an estimated increase in cytoplasmic vesicles. Further, histomorphometrical analysis revealed up-regulation of alkaline phosphatase. Osteoblasts and osteocytes showed a swollen cytoplasm with an estimated increase in the amount of rough endoplasmatic reticulum and in case of osteocytes a reduced pericellular space. Thus, current results on bone properties of 16-week old female M3R-KO are related to @entity9 phenotype. Stimulation and up-regulation of muscarinic @entity8 receptor subtype M3 expression in osteoblasts might be a possible new option for prevention and therapy of @entity9 . Pharmacological interventions and the risk of side effects have to be determined in upcoming studies.

title: Altered ultrastructure, density and @entity10 expression in bone of female muscarinic XXXX receptor M3 knockout @entity1 .

answer: @entity8


abstract: UNASSIGNED: High frequency of @entity5 is found in postmenopausal @entity0 where several molecular components were identified to be involved in @entity7 that subsequently leads to an increased @entity6 risk. @entity7 has already been determined in male @entity1 with @entity2 of muscarinic @entity8 receptor M3 (M3R-KO). Here we asked whether bone properties of female 16-week old M3R-KO present similarities to osteoporotic @entity7 by means of biomechanical, radiological, electron microscopic, cell- and molecular biological methods. Reduced biomechanical strength of M3R-KO correlated with cortical thickness and decreased @entity3 ( @entity3 ). Femur and vertebrae of M3R-KO demonstrated a declined trabecular bone volume, surface, and a higher trabecular pattern factor and structure model index (SMI) compared to @entity4 ( @entity4 ) @entity1 . In M3R-KO, the number of osteoclasts as well as the @entity10 mRNA expression was increased. Osteoclasts of M3R-KO showed an estimated increase in cytoplasmic vesicles. Further, histomorphometrical analysis revealed up-regulation of alkaline phosphatase. Osteoblasts and osteocytes showed a swollen cytoplasm with an estimated increase in the amount of rough endoplasmatic reticulum and in case of osteocytes a reduced pericellular space. Thus, current results on bone properties of 16-week old female M3R-KO are related to @entity9 phenotype. Stimulation and up-regulation of muscarinic @entity8 receptor subtype M3 expression in osteoblasts might be a possible new option for prevention and therapy of @entity9 . Pharmacological interventions and the risk of side effects have to be determined in upcoming studies.

title: Altered ultrastructure, density and @entity10 expression in bone of female muscarinic @entity8 receptor M3 knockout XXXX .

answer: @entity1


abstract: UNASSIGNED: Microglia form the immune system of the brain. Previous studies in cell cultures and animal models suggest altered activation states and cellular senescence in the aged brain. Instead, we analyzed 3 transcriptome data sets from the postmortem frontal cortex of 381 control individuals to show that microglia gene markers assemble into a transcriptional module in a gene coexpression network. These markers predominantly represented M1 and M1/M2b activation phenotypes. Expression of genes in this module generally declines over the adult life span. This decrease was more pronounced in microglia surface receptors for microglia and/or neuron crosstalk than in markers for activation state phenotypes. In addition to these receptors for exogenous signals, microglia are controlled by brain-expressed regulatory factors. We identified a subnetwork of transcription factors, including @entity1 , @entity4 , @entity2 , and @entity3 , which are master regulators (MRs) for the age-dependent microglia module. The causal contributions of these MRs on the microglia module were verified using publicly available ChIP-Seq data. Interactions of these key MRs were preserved in a protein-protein interaction network. Importantly, these MRs appear to be essential for regulating microglia homeostasis in the adult @entity0 frontal cortex in addition to their crucial roles in hematopoiesis and myeloid cell-fate decisions during embryogenesis.

title: Microglia recapitulate a hematopoietic master regulator network in  the aging XXXX frontal cortex.

answer: @entity0


abstract: INTRODUCTION AND AIMS: The Cedar Project is a community-based study aiming to identify variables associated with ever being on @entity2 maintenance treatment ( @entity3 ) among young Aboriginal @entity0 using drugs and to discuss possible barriers to @entity3 in this population. DESIGN AND METHODS: This is a prospective cohort study with recruitment by health-care providers, outreach, and @entity4 in Vancouver and Prince George. @entity0 included 605 Aboriginal @entity0 who were age 14-30 years, reported illicit drug use in the month prior to enrolment, and provided written informed consent. Variables associated with ever being on @entity3 were analysed through   (2) -testing and multivariate logistic regression, limited to @entity0 reporting opioid use (n = 397). RESULTS: Less than half of @entity0 reporting daily injection of opioids had ever been on @entity3 . In adjusted multivariate logistic regression analyses, older age [ @entity6 ; 95% confidence interval (CI) 1.08-1.28)]; female gender (OR 3.76; 95% CI 2.00-7.07); @entity5 antibody positivity (OR 2.76; 95% CI 1.53-4.95); and daily opioid injection (OR 2.59; 95% CI 1.46-4.61) were positively associated with ever being on @entity3 . Weekly or more @entity1 use (OR 0.43; 95% CI 0.21-0.87) was negatively associated with ever being on @entity3 . DISCUSSION AND CONCLUSION: @entity3 access by young Aboriginal @entity0 is low. The associations between @entity3 use and other variables need further study to steer efforts directed at recruitment into @entity3 . The removal of barriers to @entity3 and inclusion of young Aboriginal @entity0 in the development of treatment programs based on Indigenous values are urgently required to help Aboriginal @entity0 who use drugs.

title: The Cedar Project: XXXX maintenance treatment among young Aboriginal @entity0 who use opioids in two Canadian cities.

answer: @entity2


abstract: INTRODUCTION AND AIMS: The Cedar Project is a community-based study aiming to identify variables associated with ever being on @entity2 maintenance treatment ( @entity3 ) among young Aboriginal @entity0 using drugs and to discuss possible barriers to @entity3 in this population. DESIGN AND METHODS: This is a prospective cohort study with recruitment by health-care providers, outreach, and @entity4 in Vancouver and Prince George. @entity0 included 605 Aboriginal @entity0 who were age 14-30 years, reported illicit drug use in the month prior to enrolment, and provided written informed consent. Variables associated with ever being on @entity3 were analysed through   (2) -testing and multivariate logistic regression, limited to @entity0 reporting opioid use (n = 397). RESULTS: Less than half of @entity0 reporting daily injection of opioids had ever been on @entity3 . In adjusted multivariate logistic regression analyses, older age [ @entity6 ; 95% confidence interval (CI) 1.08-1.28)]; female gender (OR 3.76; 95% CI 2.00-7.07); @entity5 antibody positivity (OR 2.76; 95% CI 1.53-4.95); and daily opioid injection (OR 2.59; 95% CI 1.46-4.61) were positively associated with ever being on @entity3 . Weekly or more @entity1 use (OR 0.43; 95% CI 0.21-0.87) was negatively associated with ever being on @entity3 . DISCUSSION AND CONCLUSION: @entity3 access by young Aboriginal @entity0 is low. The associations between @entity3 use and other variables need further study to steer efforts directed at recruitment into @entity3 . The removal of barriers to @entity3 and inclusion of young Aboriginal @entity0 in the development of treatment programs based on Indigenous values are urgently required to help Aboriginal @entity0 who use drugs.

title: The Cedar Project: @entity2 maintenance treatment among young Aboriginal XXXX who use opioids in two Canadian cities.

answer: @entity0


abstract: BACKGROUND: The various clinical manifestations of @entity1 reported are more or less similar regardless of the underlying aetiological factors. Unusual presentation and unknown aetiology pose a diagnostic challenge for a periodontist. METHODS: A 34-year-old Indian @entity0 presented with the complaint of gum swelling that was sessile, lobulated, soft in consistency and bluish red in colour with ulcerated surface in some region, which was covered by the @entity2 slough. This type of enlargement was unusual and some underlying systemic pathology was suspected. But a written consultation from her physician confirmed her systemic health, which was based on clinical, radiological and haematological investigations. Histopathological examination confirmed the diagnosis of @entity1 . @entity0 was treated with oral hygiene instructions, scaling and root planning. RESULT: Within a month of conventional periodontal therapy, gum enlargement reduced markedly and @entity0 was put on oral hygiene maintenance programme. CONCLUSION: Periodontal therapy is diagnosis-driven and, to the extent possible, should address all the possible factors that impact development and progression of diseases that may affect periodontal tissue. In plaque-induced @entity3 , non-surgical periodontal therapy is still a gold standard among all the therapies available.

title: An uncommon presentation of an XXXX --responding to non-surgical periodontal therapy.

answer: @entity1


abstract: The long-term use of b blockers has been shown to improve the outcomes of @entity0 with @entity2 ( @entity2 ). However, it is still disputed whether this is a class effect, and, specifically, whether @entity3 or @entity6 are superior to @entity4 . The present study was a comparative effectiveness study of b blockers for @entity0 with @entity2 in a population-based setting. We conducted an observational cohort study using the Quebec administrative databases to identify @entity0 with @entity2 who were prescribed a b blocker after the diagnosis of @entity2 . We used descriptive statistics to characterize the @entity0 by the type of b blocker prescribed at discharge. The unadjusted mortality for users of each b blocker was calculated using Kaplan-Meier curves and compared using the log-rank test. To account for differences in follow-up and to control for differences among @entity0 characteristics, a multivariate Cox proportional hazards model was used to compare the mortality. Of the 26,787 @entity0 with @entity2 , with a median follow-up of 1.8 years per @entity0 , the crude incidence of @entity1 was 47% with @entity4 , 40% with @entity5 , 41% with @entity3 , 36% with @entity6 , and 43% with @entity7 . After controlling for several different covariates, we found that @entity3 (hazard ratio [HR] 1.04, 95% confidence interval [CI] 0.97 to 1.12, p = 0.22) and @entity6 (HR 0.96, 95% CI 0.91 to 1.01, p = 0.16) were not superior to @entity4 in improving survival. @entity5 (HR 0.82, 95% CI 0.77 to 0.87, p <0.0001) and @entity7 (HR 0.86, 95% CI 0.78 to 0.95, p = 0.004) were superior to @entity4 . In conclusion, we did not find evidence of a class effect for b blockers in @entity0 with @entity2 .

title: Population-based analysis of class effect of b blockers in XXXX .

answer: @entity2


abstract: BACKGROUND: Current approaches to the management of chronic nonspecific @entity3 (CNSLBP) have shown limited effectiveness. It appears that disruption of cortical structure and function is a feature of CNSLBP and that these changes may contribute to current treatment failures. Sensorimotor retraining approaches have been shown to be effective in the management of other long-standing @entity1 problems that are characterized by @entity2 . Similar treatments may be an option for @entity0 with CNSLBP. OBJECTIVE: The objectives of this study were to describe the effects of participation in a graded sensorimotor retraining program on @entity1 intensity, interference of @entity1 with daily life ( @entity1 interference), and self-reported disability and to evaluate the safety of the program. DESIGN: A multiple-baseline, replicated, single-case design was used for this study. METHODS: Three @entity0 with disabling CNSLBP were assessed weekly during a no-treatment baseline period. Each @entity0 then participated in a graded sensorimotor retraining program for a minimum of 10 weeks, during which clinical status was assessed weekly. Data collection continued weekly for 1 month after the end of formal treatment. RESULTS: @entity1 intensity, @entity1 interference, and disability all were reduced, and the improvements were maintained throughout the follow-up period. No adverse reactions to treatment were reported. LIMITATIONS: The findings are preliminary and were based on a single-case design. The observed improvements in clinical status may have been attributable to the effects of factors other than treatment, such as the effect of time and other, nonspecific effects. CONCLUSIONS: Positive outcomes were reported for 3 @entity0 with CNSLBP after the completion of a graded sensorimotor retraining program. However, the findings are only preliminary and require replication with more-robust study designs.

title: Managing chronic nonspecific XXXX with a sensorimotor retraining approach: exploratory multiple-baseline study of 3 @entity0 .

answer: @entity3


abstract: BACKGROUND: Current approaches to the management of chronic nonspecific @entity3 (CNSLBP) have shown limited effectiveness. It appears that disruption of cortical structure and function is a feature of CNSLBP and that these changes may contribute to current treatment failures. Sensorimotor retraining approaches have been shown to be effective in the management of other long-standing @entity1 problems that are characterized by @entity2 . Similar treatments may be an option for @entity0 with CNSLBP. OBJECTIVE: The objectives of this study were to describe the effects of participation in a graded sensorimotor retraining program on @entity1 intensity, interference of @entity1 with daily life ( @entity1 interference), and self-reported disability and to evaluate the safety of the program. DESIGN: A multiple-baseline, replicated, single-case design was used for this study. METHODS: Three @entity0 with disabling CNSLBP were assessed weekly during a no-treatment baseline period. Each @entity0 then participated in a graded sensorimotor retraining program for a minimum of 10 weeks, during which clinical status was assessed weekly. Data collection continued weekly for 1 month after the end of formal treatment. RESULTS: @entity1 intensity, @entity1 interference, and disability all were reduced, and the improvements were maintained throughout the follow-up period. No adverse reactions to treatment were reported. LIMITATIONS: The findings are preliminary and were based on a single-case design. The observed improvements in clinical status may have been attributable to the effects of factors other than treatment, such as the effect of time and other, nonspecific effects. CONCLUSIONS: Positive outcomes were reported for 3 @entity0 with CNSLBP after the completion of a graded sensorimotor retraining program. However, the findings are only preliminary and require replication with more-robust study designs.

title: Managing chronic nonspecific @entity3 with a sensorimotor retraining approach: exploratory multiple-baseline study of 3 XXXX .

answer: @entity0


abstract: BACKGROUND AND PURPOSE: "Home time" ( @entity3 ) refers to the number of days over the first 90 after @entity2 onset that a @entity0 spends residing in their own home or a relative's home versus any institutional care. It is an accessible and objective parameter, free from subjective bias, with potential as an outcome measure in @entity2 trials. We sought to validate @entity3 and assess treatment responsiveness using independent data. METHODS: We estimated @entity3 in the @entity2 Acute Ischemic NXY Treatment (SAINT) I neuroprotection trial. We compared outcomes between thrombolyzed (T) and nonthrombolyzed comparators (C) using @entity3 and the modified Rankin Scale. For our primary analysis, we adjusted for baseline covariates that significantly influence @entity3 and in sensitivity analyses considered all variables that differed between groups at baseline. We report ordinal logistic regression and analysis of covariance with 95% CIs. We describe the relationship of @entity3 with baseline National Institutes of Health @entity2 Scale and its components and with Day 90 modified Rankin Scale and Barthel Index. RESULTS: SAINT I included 1699 @entity0 from 23 countries, of whom 28.7% received alteplase. @entity3 correlated with age, baseline severity, alteplase use, side of @entity6 , presence of @entity1 , and country of @entity0 enrollment (each P<0.05). We found an association between use of alteplase with better adjusted outcomes by either measure (OR for extended @entity3 , 1.36; 95% CI, 1.08 to 1.72; P=0.009; analysis of covariance P=0.007 with a 5.5-day advantage; OR for more favorable modified Rankin Scale, 1.6; 95% CI, 1.28 to 2.00; P<0.0001; Cochran-Mantel-Haenszel P=0.046). @entity3 was significantly associated with baseline National Institutes of Health @entity2 Scale and each component of the National Institutes of Health @entity2 Scale except level of @entity4 , @entity7 , and @entity5 . @entity3 was significantly associated with Day 90 modified Rankin Scale and Barthel Index. CONCLUSIONS: @entity3 is a responsive measure for use in multinational @entity2 trials. Its inclusion as a complementary outcome is reasonable. We propose treatment effects are adjusted for age, baseline National Institutes of Health @entity2 Scale, side of @entity2 , country of enrollment, and the presence of @entity1 .

title: Home time is extended in XXXX with ischemic stroke who receive thrombolytic therapy: a validation study of home time as an outcome measure.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: Carotid endarterectomy (CEA) of stable @entity6 plaques is associated with an increased risk for @entity3 . @entity0 with transient @entity1 attack and @entity0 with and @entity2 have relatively unstable @entity6 plaques. However, carotid plaques stabilize over time after a cerebrovascular event due to plaque repair after @entity5 . These findings raised 2 questions: (1) Is preoperative clinical presentation related to @entity3 after CEA? (2) Does delayed revascularization result in a higher risk for @entity3 compared with CEA in the short term after a cerebrovascular event? METHODS: Between 2002 and 2009, 1203 @entity0 undergoing CEA were included. The impact of clinical presentation on the occurrence of @entity3 1 year after CEA was investigated and corrected for cardiovascular risk factors, medication use, and type of arteriotomy closure. Patency was assessed with standardized duplex ultrasound imaging at 1 year after CEA. @entity3 was defined as recurrent luminal narrowing >= 50% at the endarterectomy site. RESULTS: At 1 year of follow-up, @entity3 was observed more frequently in asymptomatic @entity0 than in @entity0 with transient @entity1 attack and @entity0 with @entity2 . The adjusted odds ratio (95% CI) for @entity3 was 0.56 (0.35 to 0.89) for @entity0 with transient @entity1 attack and 0.49 (0.27 to 0.87) for @entity0 with @entity2 compared with asymptomatic @entity0 . Subgroup analysis showed an increased risk for @entity3 if CEA was performed >30 days after @entity2 (adjusted OR, 2.23; 1.02 to 5.73). CONCLUSIONS: Asymptomatic @entity0 have an increased risk for @entity3 at 1 year after CEA compared with @entity0 with transient @entity4 and @entity0 with @entity2 . CEA within 30 days after @entity2 is associated with a decreased risk of @entity3 , which supports the current strategy for early surgical intervention after @entity2 .

title: XXXX after carotid surgery: the importance of clinical presentation and preoperative timing.

answer: @entity3


abstract: PURPOSE: Previous phase II studies have indicated a greatly reduced hematotoxicity of @entity4 -based regimens administered on weekly schedules. The present trial was initiated to randomly compare the @entity1 and efficacy of weekly @entity4 versus its standard 3-weekly application. METHODS: @entity0 previously untreated with chemotherapy for metastatic disease were recruited. @entity0 aged >60 years or with a Karnofsky Perfomance Status (KPS) of 60-80% were eligible for the D2 study. @entity0 were randomized to receive @entity4 either on a 3-weekly [75 mg/m(2) every 3 weeks (q3w)] or on a weekly (30 mg/m(2) on days 1, 8, and 15; q4w) schedule. Treatment was continued until a maximum of 8 cycles, unacceptable @entity1 , or disease progression. All @entity0 received standard corticosteroid prophylaxis. RESULTS: Since statistical significance for the primary endpoint ( @entity1 ) was achieved in the interim analysis, the study was closed according to the study protocol (102 of 162 @entity0 ). Compared to the standard arm, @entity5 >= grade 3 was a rare event in the weekly arm of the D2 study (per- @entity0 analysis: 4.2% q1w vs. 51.9% q3w; p < 0.0001). No difference was observed between the 2 schedules regarding the occurrence of @entity2 or @entity3 . With regard to nonhematological @entity1 , there was a higher incidence of skin/nail and hepatological @entity1 with the weekly schedule, whereas @entity6 was observed more often in the standard arm. The rate of omitted doses was significantly increased in the weekly arm (8.6% q1w vs. 0% q3w). The overall response rate was 22.9% in the weekly arm compared to 42.6% in the standard arm (p = 0.039). Time to progression was 5.4 (q1w) versus 6.3 (q3w) months (p = 0.91), and overall survival was 22.7 (q1w) versus 15.8 (q3w) months (p = 0.24). CONCLUSION: The present data support the feasibility of both weekly and 3-weekly application of @entity4 . As expected, severe @entity5 seems avoidable in weekly scheduled single-agent @entity4 and may serve as an important treatment option, particularly in elderly @entity0 and @entity0 with a reduced performance status.

title: Prospective multicenter randomized phase III study of weekly versus standard XXXX (D2) for first-line treatment of metastatic breast cancer.

answer: @entity4


abstract: PURPOSE: To investigate the clinical manifestations and diagnoses of @entity3 swelling. METHODS: The medical records of 49 @entity0 who experienced @entity3 swelling between March 2008 and June 2009 were retrospectively reviewed. The characteristics of non-arteritic anterior @entity3 (NA-AION) and @entity7 ( @entity7 ), which showed @entity3 swelling most commonly, were compared. RESULTS: NA-AION was the most common disorder (34.7%) that presented with @entity3 swelling. @entity7 was identified in 15 @entity0 (30.6%). Seven out of 49 @entity0 (14.3%) had intracranially associated diseases, such as @entity4 and @entity3 . @entity8 was noted in four @entity0 (8.2%). Other diseases (e.g., papillophlebitis, @entity5 , and @entity1 ) were seen in six @entity0 (12.2%). @entity6 was observed more commonly in @entity0 with @entity7 (p = 0.001). @entity0 with @entity7 expected a better visual prognosis than @entity0 with NA-AION (0.12    0.32 vs. 0.49    0.35, p = 0.001). CONCLUSIONS: NA-AION and @entity7 should be considered in the differential diagnosis when @entity0 with @entity3 swelling present to the neuro-ophthalmology clinic. Detailed history taking and supportive examinations, such as @entity2 and imaging tests, should also be performed as indicated. Regular follow-up of such exams is necessary for the differential diagnosis of these diseases.

title: Analysis of the causes of XXXX swelling.

answer: @entity3


abstract: A vagal origin of @entity2 has been hypothesised in @entity0 , but it has not yet been clearly demonstrated. Two vagal reflexes have been widely investigated: the diving reflex and the fear-induced central reaction, which are responsible for diving @entity4 and alarm @entity4 , respectively. The latter occurs in @entity0 mainly in the context of emotional @entity3 / @entity3 . A simultaneous occurrence of these two vagal reflexes has been observed in animals that are threatened while diving, and heart rates (HR) as low as two to six beats/min have been reported. In experiments carried out in @entity1 , a high percentage of animals that were stressed before immersion in water died suddenly due to progressive slowing of HR; autopsy revealed no signs of @entity5 . No animals died if they had not been previously stressed. These data show that vagal @entity2 can occur when the vagal cardiac fibres are synergically stimulated by two independent reflexes. In @entity0 , it has been reported that in 10-15% of @entity0 who die after falling into water, autopsy reveals little or no water in the lungs. These sudden deaths could be due to vagal overactivity. The development of an adequate laboratory model may improve knowledge of the pathophysiology of this type of vagal @entity2 and of its prevention.

title: Simultaneous occurrence of two independent vagal reflexes: a possible cause of vagal XXXX .

answer: @entity2


abstract: PURPOSE: Automated pharmacy databases are increasingly available for assessing medication use, but research on the validity of these data is incomplete. This study aimed to measure agreement on @entity3 and @entity1 use between medical records and automated pharmacy data among @entity0 with newly detected @entity2 ( @entity2 ). METHODS: @entity0 with newly detected @entity2 (n   =   1953) were previously identified in a cohort study at Group Health (GH) in Washington State. Medical records were reviewed for information on risk factors and medication use, as well as clinical care during the 6   months after @entity2 onset. Medication data were also obtained from the GH pharmacy database. We determined the sensitivity, specificity, and positive predictive value ( @entity4 ) as measures of the validity of the GH pharmacy database as compared with medical records for @entity3 and @entity1 use during the first 6 and 3   months after @entity2 onset. We also calculated the k statistic. RESULTS: For @entity3 use, in comparison with the medical record review, the sensitivity, specificity, and @entity4 for the GH pharmacy database were excellent, and agreement was almost perfect in the 3- and 6-month periods after @entity2 onset (k   =   0.92 and 0.93, respectively). For @entity1 use, the GH pharmacy database had low sensitivity but high specificity, and agreement was only fair for these two periods (k   =   0.28 and 0.31, respectively). CONCLUSIONS: The GH pharmacy database is a valuable source of data for pharmacoepidemiologic research on @entity3 use among @entity0 with @entity2 . However, the database cannot be recommended for assessment of @entity1 use. Copyright    2010 John Wiley _ Sons, Ltd.

title: Ascertainment of @entity3 and XXXX use by medical record review compared with automated pharmacy data.

answer: @entity1


abstract: PURPOSE: Automated pharmacy databases are increasingly available for assessing medication use, but research on the validity of these data is incomplete. This study aimed to measure agreement on @entity3 and @entity1 use between medical records and automated pharmacy data among @entity0 with newly detected @entity2 ( @entity2 ). METHODS: @entity0 with newly detected @entity2 (n   =   1953) were previously identified in a cohort study at Group Health (GH) in Washington State. Medical records were reviewed for information on risk factors and medication use, as well as clinical care during the 6   months after @entity2 onset. Medication data were also obtained from the GH pharmacy database. We determined the sensitivity, specificity, and positive predictive value ( @entity4 ) as measures of the validity of the GH pharmacy database as compared with medical records for @entity3 and @entity1 use during the first 6 and 3   months after @entity2 onset. We also calculated the k statistic. RESULTS: For @entity3 use, in comparison with the medical record review, the sensitivity, specificity, and @entity4 for the GH pharmacy database were excellent, and agreement was almost perfect in the 3- and 6-month periods after @entity2 onset (k   =   0.92 and 0.93, respectively). For @entity1 use, the GH pharmacy database had low sensitivity but high specificity, and agreement was only fair for these two periods (k   =   0.28 and 0.31, respectively). CONCLUSIONS: The GH pharmacy database is a valuable source of data for pharmacoepidemiologic research on @entity3 use among @entity0 with @entity2 . However, the database cannot be recommended for assessment of @entity1 use. Copyright    2010 John Wiley _ Sons, Ltd.

title: Ascertainment of XXXX and @entity1 use by medical record review compared with automated pharmacy data.

answer: @entity3


abstract: The author attended a practical training program at the Los Angeles County Coroner's Office for 2 weeks in June 2008. The systems of investigating the cause of @entity1 in the USA are not unified because every state has its own laws and systems, with Los Angeles County having a mixed system of Coroner and Medical Examiner. This report is presented to introduce the training course for medical residents at the Institute of LA. To begin, a tour through the office was provided. All residents then underwent a mask-fit-test in order to prevent @entity2 . A conference to present cases for the day was held each morning, as well as lectures once or twice per week. The whole staff instructed the trainees with care, not only in the Institute but also at the @entity1 scene and the court. Additionally, the author also attended the LAC + USC Medical Center Combined @entity0 Death Review Committee as an observer. This committee is very important for @entity0 quality assurance. The report of the coroner's autopsy is handed to the committee and the chairperson, a coroner, assesses the results of the emergency medical treatment. This greatly improves the quality of emergency medicine and reduces the number of preventable @entity1 .

title: [Resident training program of coroner's office and XXXX quality assurance in Los Angeles County, California, USA].

answer: @entity0


abstract: OBJECTIVE: To construct recombinant expression plasmid with an antibacterial peptide (attacin) mature peptide gene from Musca domestica and express an antibacterial peptide attacin in @entity3 . METHODS: The coding region of attacin mature peptide was cloned into the expression vector pPIC9K. The recombinant plasmid was linearized by digestion with Sac I and transformed into @entity4 by electroporation. The insert clones containing multiple copies were selected with @entity5 , pha, enotype and PCR. The expression of @entity4 /pPIC9K-attacin were induced with @entity1 . The supernatant of the expressed protein was analyzed by @entity0 -PAGE and Western blotting. The anti-bacterial activity of expression product was analyzed by agarose diffusion assay. RESULTS: The expression plasmid was constructed and transformed into @entity4 . @entity0 -PAGE and Western blotting analysis indicated that the recombinant containing recombinant plasmid pPIC9K-attacin expressed a Mr 22000 protein. The expression product inhibited the growth of @entity2 D31. CONCLUSION: The attacin gene from Musca domestica has been expressed in @entity3 .

title: [Heterologous expression of attacin gene from Musca domestica in XXXX ].

answer: @entity3


abstract: OBJECTIVE: To study the immune response elicited by the recombinant protein vaccine and DNA vaccine of the complex antigen ROP2-SAG1 from @entity3 . METHODS: Sixty female BALB/c @entity0 were randomly divided into 4 groups (15 per group). @entity0 in rROP2-SAGI group were immunized subcutaneously with 2.5 microg rROP2-SAG1 protein formulated in Freund's adjuvant. @entity0 in control group received only adjuvant emulsified with normal saline. @entity0 in recombinant plasmid pcROP2-SAG1 and control plasmid pcDNA3.1 groups were each injected intramuscularly with 100 microg of pcROP2-SAG1 and pcDNA3.1, respectively. All the @entity0 received three immunizations at 2-week intervals. Serum samples were collected at 25, 45, and 70 days after immunization for determining antibody IgG, and at 2 weeks after the last immunization @entity4 and @entity5 were detected all by ELISA. Cell counting kit-8 (CCK-8) was used to determine the splenocyte proliferation, and the supernatant of cultured splenocytes was collected for the detection of @entity1 by ELISA. RESULTS: The level of IgG continued to rise in rROP2-SAG1 group after immunization, and similarly in pcROP2-SAG1 group. At 2 weeks after the last immunization, level of @entity4 (1.538 +/- 0.183) was higher than that of @entity5 (0.618 +/- 0.122) (P < 0.05) in rROP2-SAG1 group. Whereas no significant difference between @entity4 (1.107 +/- 0.137) and @entity5 (0.830 +/- 0.185) was observed in pcROP2-SAG1 group (P > 0.05). Compared with the pcROP2-SAG1 group (A450 = 0.123 +/- 0.018), more significant proliferation response of splenocytes was observed in rROP2-SAG1 group (0.348 +/- 0.042) (P < 0.05). There was no significant difference (P > 0.05) of @entity1 and @entity2 in the supematant of cultured splenocytes between the groups of rROP2-SAG1 and pcROP2-SAG1. CONCLUSION: The antibody level and splenocyte proliferation have been significantly higher in @entity0 immunized with recombinant protein rROP2-SAG1 than those with recombinant plasmid pcROP2-SAG1.

title: [Immune response elicited by the recombinant protein and plasmid DNA of complex antigen ROP2-SAG1 from XXXX ].

answer: @entity3


abstract: This study is to investigate the influence and the expression of CMTM family of @entity1 on spermatogenesis suppression in the male @entity0 treated by @entity4 and @entity2 . @entity4 (50 mg kg(-1)) and @entity2 (20 mg kg(-1)) were administered to male @entity0 to induce spermatogenesis suppression. @entity3 was administrated at the dose of 5 mg kg(-1) every other day for 6 times. Sperm was collected from the left @entity5 , the count and motility of sperm were analyzed by @entity6 . Morphological change of testis tissue was observed with HE staining. The expression of CMTM family was examined by Western blotting assay. @entity4 (50 mg kg(-1)) and @entity2 (20 mg kg(-1)) decreased the count and motility of sperm, and the pathological change of testis tissue was also observed. But, @entity1 (5 mg kg(-1)) had positive effect. Furthermore, @entity8 down-expressed remarkably in the @entity4 and @entity2 treated @entity0 , the expression of the @entity8 was up-expressed after @entity1 administration. On the contrary, the expression of CMTM2 increased significantly only in @entity4 treated male @entity0 , but not in @entity2 treated male @entity0 . The expression of CMTM2 was down-expressed after @entity1 administration. However, no obvious change of CMTM2 was observed in @entity2 treated @entity0 . @entity1 did not influence the expression of @entity7 , @entity9 and @entity10 , the @entity11 , @entity12 and @entity13 of CMTM family were not detected in testis tissue. These demonstrated that the spermatogenesis effect of @entity1 (5 mg kg(-1)) was associated with the expression of CMTM family, and CMTM2 and @entity8 may take part in the spermatogenesis process.

title: [Effect of XXXX on the expression of CMTM family of the male spermatogenesis suppression @entity0 ].

answer: @entity1


abstract: This study is to investigate the influence and the expression of CMTM family of @entity1 on spermatogenesis suppression in the male @entity0 treated by @entity4 and @entity2 . @entity4 (50 mg kg(-1)) and @entity2 (20 mg kg(-1)) were administered to male @entity0 to induce spermatogenesis suppression. @entity3 was administrated at the dose of 5 mg kg(-1) every other day for 6 times. Sperm was collected from the left @entity5 , the count and motility of sperm were analyzed by @entity6 . Morphological change of testis tissue was observed with HE staining. The expression of CMTM family was examined by Western blotting assay. @entity4 (50 mg kg(-1)) and @entity2 (20 mg kg(-1)) decreased the count and motility of sperm, and the pathological change of testis tissue was also observed. But, @entity1 (5 mg kg(-1)) had positive effect. Furthermore, @entity8 down-expressed remarkably in the @entity4 and @entity2 treated @entity0 , the expression of the @entity8 was up-expressed after @entity1 administration. On the contrary, the expression of CMTM2 increased significantly only in @entity4 treated male @entity0 , but not in @entity2 treated male @entity0 . The expression of CMTM2 was down-expressed after @entity1 administration. However, no obvious change of CMTM2 was observed in @entity2 treated @entity0 . @entity1 did not influence the expression of @entity7 , @entity9 and @entity10 , the @entity11 , @entity12 and @entity13 of CMTM family were not detected in testis tissue. These demonstrated that the spermatogenesis effect of @entity1 (5 mg kg(-1)) was associated with the expression of CMTM family, and CMTM2 and @entity8 may take part in the spermatogenesis process.

title: [Effect of @entity1 on the expression of CMTM family of the male spermatogenesis suppression XXXX ].

answer: @entity0


abstract: OBJECTIVE: To evaluate an improving operative procedure and the clinical results of arthroscopically assisted treatment for @entity4 . METHODS: Between April 2006 and March 2009, 22 @entity0 (25 knees) with primary @entity2 underwent an improving arthroscopic operation, release of lateral retinaculum and suture of medial capsule and retinaculum structure. There were 5 males and 17 females with an average age of 23.6 years (range, 14-34 years). Three @entity0 had bilateral procedure. Eleven left knees and 14 right knees were involved. The disease duration was 1-10 days with an average of 5.9 days. All @entity0 had @entity3 ; of them, 14 @entity0 showed reduction without treatment, and 8 @entity0 showed dislocation at admission and were given close manipulative reduction. The results were positive for apprehension test in all @entity0 with the limitation of passive motion and for Ballottable Patella Sign in 15 cases. Lysholm score, visual analogue scale (VAS) score, and Insall scale were adopted to evaluate the effect. RESULTS: All incisions healed by first intention. All the @entity0 were followed up 12-36 months (17 months on average). During the first 3 months after operation, sunken skin in the puncture point medial to the patella was observed in 12 knees; 10 knees @entity1 of the soft tissue lateral to the patella; 15 knees felt tense in the soft tissue medial to the patella, however, all these problems disappeared or recovered gradually after rehabilitation and conservative treatment. No recurrence of dislocation was observed during the follow-up. Lysholm score was significantly improved from preoperative 67.3 +/- 5.7 to postoperative 96.6 +/- 4.5 (t = 3.241, P = 0.003) and VAS score from 6.5 +/- 0.5 to 1.8 +/- 0.4 (t = 2.154, P = 0.040). According to Insall scale, the results were excellent in 18 knees, good in 5 knees, and fair in 2 knees at 1 year after operation with an excellent and good rate of 92%. CONCLUSION: The improving procedure of arthroscopically assisted treatment for @entity4 is a minimally invasive operation and has a number of benefits. Its short-term clinical outcome was satisfactory.

title: [Arthroscopically assisted treatment for XXXX ].

answer: @entity4


abstract: OBJECTIVES: The objective was to demonstrate the derivation and the preliminary validation of a brief screening score to improve recognition of @entity4 -like @entity1 ( @entity2 ) @entity0 with unexplained @entity3 . METHODS: This cross-sectional study included 507 @entity2 @entity0 with unexplained @entity3 randomly assigned to the derivation condition (n = 201) or the validation condition (n = 306). The @entity1 Interview Schedule for DSM-IV (ADIS-IV) acted as the criterion standard for @entity4 diagnosis. Receiver operating characteristic (ROC) curves were used to determine which of the sociodemographic, medical, and questionnaire response variables best predicted the presence of @entity4 -like @entity1 in the derivation condition. The selected predictors were entered in a logistic regression analysis to determine variables to be included in the screening score. The predictive validity of the resulting score was evaluated in both conditions. RESULTS: The four-item Panic Screening Score (PSS) identified @entity4 -like @entity1 with a sensitivity of 63% (95% confidence interval [CI] = 52% to 73%) and a specificity of 84% (95% CI = 76% to 90%) in the derivation phase. The positive predictive value was 74% (95% CI = 62% to 93%) and the negative predictive value was 76% (95% CI = 68% to 89%). In the validation phase, the sensitivity and specificity were 53% (95% CI = 44% to 62%) and 85% (95% CI = 78% to 89%), respectively. The positive predictive value was 72% (95% CI = 62% to 80%) and the negative predictive value was 71% (95% CI = 65% to 77%). CONCLUSIONS: The PSS may be useful to identify @entity0 with unexplained @entity3 who could benefit from referral to mental health professionals or their primary care providers for evaluation of @entity4 and @entity4 . Prospective studies to improve and validate the PSS, followed by impact analysis, are mandatory before clinical implementation.

title: Preliminary investigation of the Panic Screening Score for XXXX @entity0 with unexplained @entity3 .

answer: @entity2


abstract: OBJECTIVES: The objective was to demonstrate the derivation and the preliminary validation of a brief screening score to improve recognition of @entity4 -like @entity1 ( @entity2 ) @entity0 with unexplained @entity3 . METHODS: This cross-sectional study included 507 @entity2 @entity0 with unexplained @entity3 randomly assigned to the derivation condition (n = 201) or the validation condition (n = 306). The @entity1 Interview Schedule for DSM-IV (ADIS-IV) acted as the criterion standard for @entity4 diagnosis. Receiver operating characteristic (ROC) curves were used to determine which of the sociodemographic, medical, and questionnaire response variables best predicted the presence of @entity4 -like @entity1 in the derivation condition. The selected predictors were entered in a logistic regression analysis to determine variables to be included in the screening score. The predictive validity of the resulting score was evaluated in both conditions. RESULTS: The four-item Panic Screening Score (PSS) identified @entity4 -like @entity1 with a sensitivity of 63% (95% confidence interval [CI] = 52% to 73%) and a specificity of 84% (95% CI = 76% to 90%) in the derivation phase. The positive predictive value was 74% (95% CI = 62% to 93%) and the negative predictive value was 76% (95% CI = 68% to 89%). In the validation phase, the sensitivity and specificity were 53% (95% CI = 44% to 62%) and 85% (95% CI = 78% to 89%), respectively. The positive predictive value was 72% (95% CI = 62% to 80%) and the negative predictive value was 71% (95% CI = 65% to 77%). CONCLUSIONS: The PSS may be useful to identify @entity0 with unexplained @entity3 who could benefit from referral to mental health professionals or their primary care providers for evaluation of @entity4 and @entity4 . Prospective studies to improve and validate the PSS, followed by impact analysis, are mandatory before clinical implementation.

title: Preliminary investigation of the Panic Screening Score for @entity2 @entity0 with unexplained XXXX .

answer: @entity3


abstract: OBJECTIVES: The objective was to demonstrate the derivation and the preliminary validation of a brief screening score to improve recognition of @entity4 -like @entity1 ( @entity2 ) @entity0 with unexplained @entity3 . METHODS: This cross-sectional study included 507 @entity2 @entity0 with unexplained @entity3 randomly assigned to the derivation condition (n = 201) or the validation condition (n = 306). The @entity1 Interview Schedule for DSM-IV (ADIS-IV) acted as the criterion standard for @entity4 diagnosis. Receiver operating characteristic (ROC) curves were used to determine which of the sociodemographic, medical, and questionnaire response variables best predicted the presence of @entity4 -like @entity1 in the derivation condition. The selected predictors were entered in a logistic regression analysis to determine variables to be included in the screening score. The predictive validity of the resulting score was evaluated in both conditions. RESULTS: The four-item Panic Screening Score (PSS) identified @entity4 -like @entity1 with a sensitivity of 63% (95% confidence interval [CI] = 52% to 73%) and a specificity of 84% (95% CI = 76% to 90%) in the derivation phase. The positive predictive value was 74% (95% CI = 62% to 93%) and the negative predictive value was 76% (95% CI = 68% to 89%). In the validation phase, the sensitivity and specificity were 53% (95% CI = 44% to 62%) and 85% (95% CI = 78% to 89%), respectively. The positive predictive value was 72% (95% CI = 62% to 80%) and the negative predictive value was 71% (95% CI = 65% to 77%). CONCLUSIONS: The PSS may be useful to identify @entity0 with unexplained @entity3 who could benefit from referral to mental health professionals or their primary care providers for evaluation of @entity4 and @entity4 . Prospective studies to improve and validate the PSS, followed by impact analysis, are mandatory before clinical implementation.

title: Preliminary investigation of the Panic Screening Score for @entity2 XXXX with unexplained @entity3 .

answer: @entity0


abstract: STUDY DESIGN: Prospective radiological analysis of @entity0 with @entity5 . OBJECTIVE: To analyze sagittal spinal alignment and pelvic orientation in @entity5 @entity0 . SUMMARY OF BACKGROUND DATA: Knowledge of sagittal spinopelvic parameters is important for the treatment of @entity5 , because they differ from those of the normal population and can induce @entity2 . METHODS: The study and control groups were composed of 32 @entity5 @entity0 and 24 healthy volunteers, respectively. All underwent lateral radiography of the whole spine including hip joints. The radiographic parameters examined were @entity6 ( @entity6 ), pelvic tilt, pelvic incidence (PI), S1 overhang, @entity3 , T10-L2 @entity3 , @entity4 (LL1, LL2), and sagittal balance. Statistical analysis was performed to identify significant differences between the two groups. In addition, correlations between parameters and symptoms were sought. RESULTS: Sagittal spinopelvic parameters, namely, pelvic tilt, pelvic incidence, S1 overhang, @entity3 , T10-L2 @entity3 , @entity4 1 and sagittal balance were found to be significantly different in the @entity0 and control groups (P < 0.05). In addition, sagittal parameters were found to be related to each other in the @entity0 group (P < 0.05), that is, PI was related to @entity6 and pelvic tilt, and LL was related to @entity3 . Furthermore, in terms of relations between spinal and pelvic parameters, LL was related to @entity6 and PI, and sagittal balance was related to @entity6 and PI. Furthermore, LL and T10-L2 @entity3 were found to be related to @entity2 (P < 0.05), whereas no other parameter was found to be related to VAS scores. CONCLUSION: Sagittal parameters and possible relationships between sagittal parameters and symptoms were found to be significantly different in @entity5 @entity0 and normal healthy controls. The present study shows that sagittal spinal and pelvic parameters can assist the treatment of @entity1 in @entity5 @entity0 .

title: Analysis of sagittal spinopelvic parameters in XXXX .

answer: @entity5


abstract: OBJECTIVE: Family medicine (also called general practice) is a specialty with a focus on primary care. In @entity0 , not all primary care is provided by specialists. Efforts are underway to improve primary care by improving the provision of primary care, establishing referral chains, and having care provided by general practitioners after transition training or by family medicine specialists. We investigated the relationship between @entity1 ( @entity1 ) and primary care in @entity0 , to provide a snapshot of the current situation and baseline data to assess the effects of current and future reforms. METHODS: A cross-sectional survey was done of 375 primary care physicians: 138 general practitioners (GPs), 121 family medicine (FM) trainees, and 116 FM specialists. They were asked 30 questions assessing general characteristics, knowledge, and training in @entity1 ; general attitudes towards @entity1 ; resources used to support clinical decisions; possible barriers to @entity1 practice; and opinions on future practice of @entity1 . Data were analyzed with SPSS 12.0. RESULTS: Compared with the other physicians, FM specialists had significantly more Internet access, used the Internet for medical purposes more often and for longer hours, had published more scientific papers, searched MEDLINE or similar databases more often, and were more confident about conducting literature searches. FM specialists had significantly higher rates of training in @entity1 and critical appraisal. For all types of physicians surveyed, the main reported barrier to practicing @entity1 was lack of training in @entity1 . CONCLUSIONS: Attitudes toward @entity1 differ significantly between GPs and FM specialists working in primary care in @entity0 , which we believe results in variation in medical provision. The differences between these two groups of physicians should be investigated further, and means of improving the provision of care should be reported to policy makers.

title: Is primary care evidence-based in XXXX ? A cross-sectional survey of 375 primary care physicians.

answer: @entity0


abstract: INTRODUCTION: @entity1 in the sinonasal region occurs rarely and the primary site may be elusive. This case highlights the possibility of an occult @entity3 manifesting with nasal symptoms and the risk of severe @entity2 following nasal biopsy. CASE PRESENTATION: We report the case of a 79-year-old Caucasian @entity0 who presented with a six-week history of intermittent left-sided nosebleeds. She was fit, without previous surgery or anticoagulation. Nasal endoscopy and computed tomography showed a hemorrhagic mass occupying her left ethmoid cells and middle meatus. After a highly hemorrhagic biopsy, the lesion was histologically confirmed as @entity4 . Screening revealed a right kidney mass with widespread metastases. Palliative radiotherapy to the sinonasal metastasis and systemic treatment rendered her free of symptoms nine months after initial presentation. CONCLUSIONS: General practitioners and ear, nose and throat (ENT) doctors are very often confronted with @entity5 . A small minority of @entity0 with @entity5 show a primary or metastatic nasal mass. Detection of the origin of secondary sinonasal masses requires a high index of suspicion and examination of infraclavicular sites by a multidisciplinary team. @entity4 metastases are prone to severe @entity2 during any surgical intervention, therefore, preoperative embolization is recommended. Resection or radiotherapy to the sinonasal metastasis of renal origin is justified in order to prevent recurrent nosebleeds.

title: XXXX manifesting with @entity5 in a @entity0 : a case report.

answer: @entity4


abstract: INTRODUCTION: @entity1 in the sinonasal region occurs rarely and the primary site may be elusive. This case highlights the possibility of an occult @entity3 manifesting with nasal symptoms and the risk of severe @entity2 following nasal biopsy. CASE PRESENTATION: We report the case of a 79-year-old Caucasian @entity0 who presented with a six-week history of intermittent left-sided nosebleeds. She was fit, without previous surgery or anticoagulation. Nasal endoscopy and computed tomography showed a hemorrhagic mass occupying her left ethmoid cells and middle meatus. After a highly hemorrhagic biopsy, the lesion was histologically confirmed as @entity4 . Screening revealed a right kidney mass with widespread metastases. Palliative radiotherapy to the sinonasal metastasis and systemic treatment rendered her free of symptoms nine months after initial presentation. CONCLUSIONS: General practitioners and ear, nose and throat (ENT) doctors are very often confronted with @entity5 . A small minority of @entity0 with @entity5 show a primary or metastatic nasal mass. Detection of the origin of secondary sinonasal masses requires a high index of suspicion and examination of infraclavicular sites by a multidisciplinary team. @entity4 metastases are prone to severe @entity2 during any surgical intervention, therefore, preoperative embolization is recommended. Resection or radiotherapy to the sinonasal metastasis of renal origin is justified in order to prevent recurrent nosebleeds.

title: @entity4 manifesting with XXXX in a @entity0 : a case report.

answer: @entity5


abstract: INTRODUCTION: @entity1 in the sinonasal region occurs rarely and the primary site may be elusive. This case highlights the possibility of an occult @entity3 manifesting with nasal symptoms and the risk of severe @entity2 following nasal biopsy. CASE PRESENTATION: We report the case of a 79-year-old Caucasian @entity0 who presented with a six-week history of intermittent left-sided nosebleeds. She was fit, without previous surgery or anticoagulation. Nasal endoscopy and computed tomography showed a hemorrhagic mass occupying her left ethmoid cells and middle meatus. After a highly hemorrhagic biopsy, the lesion was histologically confirmed as @entity4 . Screening revealed a right kidney mass with widespread metastases. Palliative radiotherapy to the sinonasal metastasis and systemic treatment rendered her free of symptoms nine months after initial presentation. CONCLUSIONS: General practitioners and ear, nose and throat (ENT) doctors are very often confronted with @entity5 . A small minority of @entity0 with @entity5 show a primary or metastatic nasal mass. Detection of the origin of secondary sinonasal masses requires a high index of suspicion and examination of infraclavicular sites by a multidisciplinary team. @entity4 metastases are prone to severe @entity2 during any surgical intervention, therefore, preoperative embolization is recommended. Resection or radiotherapy to the sinonasal metastasis of renal origin is justified in order to prevent recurrent nosebleeds.

title: @entity4 manifesting with @entity5 in a XXXX : a case report.

answer: @entity0


abstract: BACKGROUND: Copy number variation ( @entity2 ) represents another important source of genetic variation complementary to single nucleotide polymorphism (SNP). High-density SNP array data have been routinely used to detect @entity0 CNVs, many of which have significant functional effects on gene expression and @entity0 diseases. In the dairy industry, a large quantity of SNP genotyping results are becoming available and can be used for @entity2 discovery to understand and accelerate genetic improvement for complex traits. RESULTS: We performed a systematic analysis of @entity2 using the @entity1 HapMap SNP genotyping data, including 539 animals of 21 modern @entity1 breeds and 6 outgroups. After correcting genomic waves and considering the pedigree information, we identified 682 candidate @entity2 regions, which represent 139.8 megabases (~4.60%) of the genome. Selected CNVs were further experimentally validated and we found that copy number "gain" CNVs were predominantly clustered in tandem rather than existing as interspersed duplications. Many @entity2 regions (~56%) overlap with @entity1 genes (1,263), which are significantly enriched for immunity, lactation, reproduction and rumination. The overlap of this new dataset and other published @entity2 studies was less than 40%; however, our discovery of large, high frequency (> 5% of animals surveyed) @entity2 regions showed 90% agreement with other studies. These results highlight the differences and commonalities between technical platforms. CONCLUSIONS: We present a comprehensive genomic analysis of @entity1 CNVs derived from SNP data which will be a valuable genomic variation resource. Combined with SNP detection assays, gene-containing @entity2 regions may help identify genes undergoing artificial selection in domesticated animals.

title: Genomic characteristics of XXXX copy number variations.

answer: @entity1


abstract: PURPOSE: To prospectively evaluate the feasibility and diagnostic accuracy of high spatial resolution myocardial perfusion imaging during high dose @entity1 / @entity4 stress magnetic resonance (DSMR) for the detection of @entity2 ( @entity2 ). METHODS AND RESULTS: DSMR-wall motion was combined with perfusion imaging (DSMR-perfusion) in 78 @entity0 prior to clinically indicated invasive coronary angiography. For DSMR-perfusion an in-plane spatial resolution of 1.5   1.5mm(2) was attained by using 8   k-space and time sensitivity encoding (k-t SENSE). Image quality and extent of artifacts during perfusion imaging were evaluated. Wall motion and perfusion data were interpreted sequentially. Significant @entity2 ( @entity3 >=  70%) was present in 52 @entity0 and involved 86 coronary territories. One @entity0 did not reach target heart rate despite maximum infusion of @entity1 / @entity4 . Two studies (3%) were non-diagnostic due k-t SENSE related artifacts resulting from insufficient breathhold capability. Overall image quality was good. Dark-rim artifacts were limited to the endocardial border at a mean width of 1.8mm. The addition of DSMR-perfusion to DSMR-wall motion data improved sensitivity for the detection of @entity2 (92% vs. 81%, P=0.03) and accurate determination of disease extent (85% vs. 66% of territories, P<0.001). There were no significant differences between DSMR-perfusion and DSRM-wall motion regarding overall specificity (83% vs. 87%, P=1) and accuracy (89% vs. 83%, P=0.13). CONCLUSION: High spatial resolution DSMR-perfusion imaging at maximum stress level was feasible, improved sensitivity over DSMR-wall motion for the detection of @entity2 and allowed an accurate determination of disease extent. Specificity of DSMR-perfusion with k-t SENSE improved compared to prior studies using lower spatial resolution.

title: High spatial resolution myocardial perfusion imaging during high dose @entity1 / XXXX stress magnetic resonance using k-t SENSE.

answer: @entity4


abstract: PURPOSE: To prospectively evaluate the feasibility and diagnostic accuracy of high spatial resolution myocardial perfusion imaging during high dose @entity1 / @entity4 stress magnetic resonance (DSMR) for the detection of @entity2 ( @entity2 ). METHODS AND RESULTS: DSMR-wall motion was combined with perfusion imaging (DSMR-perfusion) in 78 @entity0 prior to clinically indicated invasive coronary angiography. For DSMR-perfusion an in-plane spatial resolution of 1.5   1.5mm(2) was attained by using 8   k-space and time sensitivity encoding (k-t SENSE). Image quality and extent of artifacts during perfusion imaging were evaluated. Wall motion and perfusion data were interpreted sequentially. Significant @entity2 ( @entity3 >=  70%) was present in 52 @entity0 and involved 86 coronary territories. One @entity0 did not reach target heart rate despite maximum infusion of @entity1 / @entity4 . Two studies (3%) were non-diagnostic due k-t SENSE related artifacts resulting from insufficient breathhold capability. Overall image quality was good. Dark-rim artifacts were limited to the endocardial border at a mean width of 1.8mm. The addition of DSMR-perfusion to DSMR-wall motion data improved sensitivity for the detection of @entity2 (92% vs. 81%, P=0.03) and accurate determination of disease extent (85% vs. 66% of territories, P<0.001). There were no significant differences between DSMR-perfusion and DSRM-wall motion regarding overall specificity (83% vs. 87%, P=1) and accuracy (89% vs. 83%, P=0.13). CONCLUSION: High spatial resolution DSMR-perfusion imaging at maximum stress level was feasible, improved sensitivity over DSMR-wall motion for the detection of @entity2 and allowed an accurate determination of disease extent. Specificity of DSMR-perfusion with k-t SENSE improved compared to prior studies using lower spatial resolution.

title: High spatial resolution myocardial perfusion imaging during high dose XXXX / @entity4 stress magnetic resonance using k-t SENSE.

answer: @entity1


abstract: BACKGROUND: Open @entity1 occur uncommonly. Despite serious sequelae, they have been infrequently reviewed. METHODS: We conducted a retrospective review of all @entity0 with @entity4 in our department from January 2001 to April 2010. RESULTS: Forty-one @entity0 (32 @entity0 , 9 @entity0 ) with these injuries were identified. The average Injury Severity Score (ISS) was 31.4, with 80% of @entity0 having a score >= 16. The average blood transfusion in the first 24h was 17.2 units, and the average hospital stay was 60 days. Overall mortality was 24% (n=10): 3 early deaths and 7 late deaths. Factors associated with overall mortality by univariate analysis were ISS, @entity3 , GCS, age, @entity2 , Gustilo classification of soft-tissue injury, and Young classification of bony @entity1 . Factors associated with late mortality by univariate analysis were: ISS, @entity3 , @entity2 , Gustilo classification of soft-tissue injury, and blood transfusion in the first 24 h. Moreover, multivariate analysis showed that only @entity3 was independently associated with both overall and late mortality. CONCLUSION: Despite treatment advances, mortality rates remain high in @entity0 with @entity4 . The urogenital and/or intra-abdominal injuries are not associated with mortality. @entity3 <=8 might be a predictor of poor outcome in @entity4 @entity0 . Open reduction and internal fixation might be used in those unstable @entity1 without gross contamination in the @entity1 region after extensive cleansing and lavage. More emphasis needs to be placed on this injury complex.

title: Management and outcome of XXXX : a retrospective study of 41 cases.

answer: @entity4


abstract: BACKGROUND: Although risk factors for @entity1 are well described, prognostic risk scores to estimate risk in prevalent transplant recipients are limited. STUDY DESIGN: Development and validation of risk-prediction instruments. SETTING _ @entity0 : The development data set included 2,763 prevalent @entity0 more than 12 months posttransplant enrolled into the LOTESS (Long Term Efficacy and Safety Surveillance) Study. The validation data set included 731 @entity0 who underwent transplant at a single UK center. PREDICTOR: Estimated glomerular filtration rate (eGFR) and other risk factors were evaluated using Cox regression. OUTCOME: Scores for death-censored and @entity2 were based on the summed hazard ratios for baseline predictor variables. Predictive performance was assessed using calibration (Hosmer-Lemeshow statistic), discrimination (C statistic), and clinical reclassification (net reclassification improvement) compared with eGFR alone. RESULTS: In the development data set, 196 @entity0 died and another 225 experienced @entity2 . eGFR, recipient age, race, serum @entity4 and albumin levels, declining eGFR, and prior acute rejection predicted death-censored @entity2 . eGFR, recipient age, sex, serum urea and albumin levels, and declining eGFR predicted @entity2 . In the validation data set, 44 @entity0 died and another 101 experienced @entity2 . The weighted scores comprising these variables showed adequate discrimination and calibration for death-censored (C statistic, 0.83; 95% CI, 0.75-0.91; Hosmer-Lemeshow   (2)P = 0.8) and overall (C statistic, 0.70; 95% CI, 0.64-0.77; Hosmer-Lemeshow   (2)P = 0.5) @entity2 . However, the scores failed to reclassify risk compared with eGFR alone (net reclassification improvements of 7.6% [95% CI, -0.2 to 13.4; P = 0.09] and 4.3% [95% CI, -2.7 to 11.8; P = 0.3] for death-censored and @entity2 , respectively). LIMITATIONS: Retrospective analysis of predominantly @entity3 -treated @entity0 ; limited study size and categorization of variables may limit power to detect effect. CONCLUSIONS: Although the scores performed well regarding discrimination and calibration, clinically relevant risk reclassification over eGFR alone was not evident, emphasizing the stringent requirements for such scores. Further studies are required to develop and refine this process.

title: Development and evaluation of a composite risk score to predict XXXX .

answer: @entity1


abstract: INTRODUCTION: The impact of @entity1 ( @entity1 ), which continues to occur among @entity0 in developing countries, can severely affect the health of the @entity0 while the condition persists. This study was designed to discover the effect of successful @entity1 repair on affected @entity0 's quality of life. METHODS: A comparison of the quality of life of a cross-section of @entity0 who had @entity1 was carried out before and 6 months after successful repair. Quality of life was assessed using the WHO Quality of Life (WHOQOL)-BREF Questionnaire. RESULTS: Of the 150 @entity0 studied, only 20% felt satisfied with their general state of health and quality of life before the repair, while this increased to 90% following successful repair (highly statistically significant at p<0.000). In the physical health domain, the mean quality of life score was 67.9    4.4 before and 69.3    3.4 after successful repair (p<0.01). In the mental health domain, the mean quality of life score was 32.4    8.7 before and 74.7    3.2 after successful repair (p<0.005). In the social health domain, the mean score was 20.2    2.7 before and 69.7    2.3 after successful repair (p<0.001). In the environment domain, the mean score of quality of life was 60.3    4.3 before repair and 59.7    2.7 after successful repair (comparable at p<0.2). CONCLUSION: Successful repair of @entity1 is associated with significant improvement in the multidimensional quality of life among affected @entity0 .

title: Quality of life following successful repair of XXXX in Nigeria.

answer: @entity1


abstract: INTRODUCTION: The aim of this study is to evaluate the prognostic factors and outcome of @entity0 operated for @entity8 ( @entity8 ) @entity1 , in comparison with @entity5 ( @entity5 ) and @entity7 ( @entity7 ). METHODS: a retrospective review of our thoracic @entity3 surgical database for @entity0 operated for @entity8 , @entity7 and @entity5 between January, 1995 and December, 2009 was done. RESULTS: Forty-eight @entity0 (39 males, 81.3%) had @entity8 ; complete @entity3 resection and lymphadenectomy was accomplished in all @entity0 . A higher stage at presentation was observed in @entity8 , as compared to @entity5 or @entity7 (p=0.0001). Three and 5-year survival rates were 25% and 15%. @entity8 overall survival was worse than @entity5 or @entity7 (p=0.0005). Three and 5-year survival rates of @entity8 Stage I were similar to those of Stage IIIA @entity5 or @entity7 . More than half @entity8 @entity0 developed distant @entity2 ( @entity2 ) or local recurrences. Brain @entity2 were the most frequent. Median survival for those @entity0 was 8  2.3 months. Postoperative @entity6 -based chemotherapy statistically improved @entity0 survival (p=0.02). In the multivariate analysis, the presence of @entity2 (p=0.001), the @entity3 perineural invasion (p=0.01) and the @entity3 stage (p=0.0005) were factors associated with poor prognosis. Adjuvant chemotherapy was a significant positive prognostic factor (p=0.00001). CONCLUSIONS: @entity8 are uncommon and @entity4 . Adjuvant chemotherapy should be administered even in Stage I radically resected @entity3 . A whole brain postoperative prophylactic radiotherapy could be proposed to reduce risk of developing brain @entity2 .

title: XXXX : a histologic subtype with poor prognosis.

answer: @entity1


abstract: BACKGROUND: For @entity5 , the fronto-basal exposure is considered the standard approach. The superior interhemispheric (IH) approach is less described in the literature. OBJECTIVE: To assess the surgical complications, functional outcome (visual, olfaction), morbidity and mortality rates and late recurrence, after resection by superior IH approach of midline @entity3 . METHODS: Between 1998 and 2008, 52 consecutive @entity0 with midline @entity4 on the anterior portion of the skull base (mean age: 63.8    13.1; sex ratio F/M: 3.7) were operated on via the superior IH approach. After a mean follow-up of 56.9    32.9 months, an independent neurosurgeon proposed a prospective examination of functional outcome to each @entity0 , as well as a visual and olfactory function assessment. RESULTS: Fifty-two @entity0 were divided into a group with @entity4 (n=34) and another with @entity4 (n=18). The outcome was characterized by @entity1 in 13 @entity0 (25%), mortality rate in two (3.8%) and long-term morbidity at in 17 (37%) of 50 surviving @entity0 . Based on multivariate analysis, no prognosis factor was significant as regards the favorable outcome. The mean postoperative KPS score (86.6    9.4) was significantly improved. However, @entity2 was observed in four @entity0 (8%), @entity6 -anosmia in 34 (68%) and visual acuity deteriorated in one (2%). CONCLUSION: The superior IH approach could be considered a safe anteriorly orientated midline approach for removal OGM and TSM @entity4 .

title: Superior interhemispheric approach for midline XXXX from the anterior cranial base.

answer: @entity4


abstract: BACKGROUND: Probiotics may improve a @entity0 's health by regulating their immune function. Some studies show that probiotic strains can prevent @entity2 . However, no evidence of the benefits of probiotics for @entity2 (URTIs) and related potential adverse effects has been published. OBJECTIVES: To assess the effectiveness and safety of probiotics for preventing acute URTIs. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 2), which includes the Cochrane Acute @entity2 Group's Specialised Register, MEDLINE (Ovid) (1950 to May week 1, 2011), EMBASE (1974 to May 2011), Web of Science which includes Science Citation Index (from 1900 to May 2011) and Conference Proceedings Citation Index (from 1991 to May 2011), the Chinese Biomedical Literature Database, which includes the China Biological Medicine Database (from 1978 to May 2011), the Chinese Medicine Popular Science Literature Database (from 2000 to May 2011) and the Masters Degree Dissertation of Beijing Union Medical College Database (from 1981 to May 2011). SELECTION CRITERIA: @entity1 ( @entity1 ) comparing probiotics with placebo to prevent acute URTIs. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed eligibility, quality of trials and extracted data. MAIN RESULTS: We included 14 @entity1 , although we could only extract available data to meta-analyse in 10 trials which involved 3451 @entity0 . We found that probiotics were better than placebo when measuring the number of @entity0 experiencing episodes of acute URTI: at least one episode: odds ratio (OR) 0.58; 95% confidence interval (CI) 0.36 to 0.92; at least three episodes: OR 0.53; 95% CI 0.36 to 0.80; rate ratio of episodes of acute URTI: rate ratio 0.88; 95% CI 0.81 to 0.96; and reduced antibiotic prescription rates for acute URTIs: OR 0.67; 95% CI 0.45 to 0.98. Probiotics and placebo were similar when measuring the mean duration (MD) of an episode of acute URTI: MD -0.29; 95% CI -3.71 to 3.13 and adverse events: OR 0.92; 95% CI 0.37 to 2.28. Side effects of probiotics were minor and gastrointestinal symptoms were the most common. We found that some subgroups had a high level of heterogeneity when conducting pooled analyses. AUTHORS' CONCLUSIONS: Probiotics were better than placebo in reducing the number of @entity0 experiencing episodes of acute URTIs, the rate ratio of episodes of acute URTI and reducing antibiotic use. This indicates that probiotics may be more beneficial than placebo for preventing acute URTIs. However, the results have some limitations and there were no data for older @entity0 .

title: Probiotics for preventing XXXX .

answer: @entity2


abstract: OBJECTIVES: The treatment for @entity2 (AC) @entity3 remains controversial because of the elevated level of complications and related morbidity. The objective of this study was to evaluate clinical outcomes, radiographic results, and the complications after arthroscopic stabilization of acute stages III or IV (Rockwood classification) @entity4 . MATERIAL AND METHODS: Sixteen @entity0 (15 males and one female) found to have Rockwood stage III or IV @entity3 were operated. All the @entity0 were stabilized arthroscopically with a synthetic ligament placed between the clavicle and the coracoid. The application of the synthetic ligament reduced the dislocation and stabilized the AC joint, allowing healing of the coracoacromial ligament. Results were assessed clinically (Constant score) and radiographically before and a mean 12 months after the treatment. RESULTS: Despite the excellent clinical results at the last follow-up both in terms of the Constant score (mean, 91 points; range, 60-100) and @entity0 satisfaction, two @entity0 required revision surgery while some had @entity1 over the clavicular button. The X-rays showed three cases of partial loss of reduction due to distal migration of the flip button. DISCUSSION: Arthroscopically assisted treatment of acute @entity3 is advantageous because it provides good clinical results and few complications. The rate of recurrence and the postoperative loss of reduction requires better definition of the indications and improvement of the surgical implants and technique. LEVEL OF EVIDENCE: Level IV. Prospective cohort study.

title: Endoscopically assisted reconstruction of acute XXXX using a synthetic ligament. Outcomes at 12 months.

answer: @entity3


abstract: BACKGROUND: Prenatal loss, the death of a fetus/ @entity0 through @entity4 or @entity5 , is associated with significant @entity2 and @entity1 , particularly in a subsequent pregnancy. AIMS: This study examined the degree to which symptoms of @entity2 and @entity1 associated with a previous loss persisted following a subsequent successful pregnancy. METHOD: Data were derived from the Avon Longitudinal Study of Parents and @entity0 cohort, a longitudinal cohort study in the west of England that has followed mothers from pregnancy into the postnatal period. A total of 13,133 mothers reported on the number and conditions of previous perinatal losses and provided self-report measures of @entity2 and @entity1 at 18 and 32 weeks' gestation and at 8 weeks and 8, 21 and 33 months postnatally. Controls for pregnancy outcome and obstetric and psychosocial factors were included. RESULTS: Generalised estimating equations indicated that the number of previous @entity4 /stillbirths significantly predicted symptoms of @entity2 (b = 0.18, s.e. = 0.07, P<0.01) and @entity1 (b = 0.14, s.e. = 0.05, P<0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors. This association remained constant across the pre- and postnatal period, indicating that the impact of a previous @entity3 did not diminish significantly following the birth of a healthy @entity0 . CONCLUSIONS: @entity2 and @entity1 associated with a previous @entity3 shows a persisting pattern that continues after the birth of a subsequent (healthy) @entity0 . Interventions targeting @entity0 with previous @entity3 may improve the health outcomes of @entity0 and their @entity0 .

title: Previous XXXX as a predictor of perinatal @entity2 and @entity1 .

answer: @entity3


abstract: BACKGROUND: Prenatal loss, the death of a fetus/ @entity0 through @entity4 or @entity5 , is associated with significant @entity2 and @entity1 , particularly in a subsequent pregnancy. AIMS: This study examined the degree to which symptoms of @entity2 and @entity1 associated with a previous loss persisted following a subsequent successful pregnancy. METHOD: Data were derived from the Avon Longitudinal Study of Parents and @entity0 cohort, a longitudinal cohort study in the west of England that has followed mothers from pregnancy into the postnatal period. A total of 13,133 mothers reported on the number and conditions of previous perinatal losses and provided self-report measures of @entity2 and @entity1 at 18 and 32 weeks' gestation and at 8 weeks and 8, 21 and 33 months postnatally. Controls for pregnancy outcome and obstetric and psychosocial factors were included. RESULTS: Generalised estimating equations indicated that the number of previous @entity4 /stillbirths significantly predicted symptoms of @entity2 (b = 0.18, s.e. = 0.07, P<0.01) and @entity1 (b = 0.14, s.e. = 0.05, P<0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors. This association remained constant across the pre- and postnatal period, indicating that the impact of a previous @entity3 did not diminish significantly following the birth of a healthy @entity0 . CONCLUSIONS: @entity2 and @entity1 associated with a previous @entity3 shows a persisting pattern that continues after the birth of a subsequent (healthy) @entity0 . Interventions targeting @entity0 with previous @entity3 may improve the health outcomes of @entity0 and their @entity0 .

title: Previous @entity3 as a predictor of perinatal @entity2 and XXXX .

answer: @entity1


abstract: BACKGROUND: Prenatal loss, the death of a fetus/ @entity0 through @entity4 or @entity5 , is associated with significant @entity2 and @entity1 , particularly in a subsequent pregnancy. AIMS: This study examined the degree to which symptoms of @entity2 and @entity1 associated with a previous loss persisted following a subsequent successful pregnancy. METHOD: Data were derived from the Avon Longitudinal Study of Parents and @entity0 cohort, a longitudinal cohort study in the west of England that has followed mothers from pregnancy into the postnatal period. A total of 13,133 mothers reported on the number and conditions of previous perinatal losses and provided self-report measures of @entity2 and @entity1 at 18 and 32 weeks' gestation and at 8 weeks and 8, 21 and 33 months postnatally. Controls for pregnancy outcome and obstetric and psychosocial factors were included. RESULTS: Generalised estimating equations indicated that the number of previous @entity4 /stillbirths significantly predicted symptoms of @entity2 (b = 0.18, s.e. = 0.07, P<0.01) and @entity1 (b = 0.14, s.e. = 0.05, P<0.01) in a subsequent pregnancy, independent of key psychosocial and obstetric factors. This association remained constant across the pre- and postnatal period, indicating that the impact of a previous @entity3 did not diminish significantly following the birth of a healthy @entity0 . CONCLUSIONS: @entity2 and @entity1 associated with a previous @entity3 shows a persisting pattern that continues after the birth of a subsequent (healthy) @entity0 . Interventions targeting @entity0 with previous @entity3 may improve the health outcomes of @entity0 and their @entity0 .

title: Previous @entity3 as a predictor of perinatal XXXX and @entity1 .

answer: @entity2


abstract: The current study investigated the effect of natural @entity3 extracted from fenugreek seeds, in comparison with the pure standard @entity3 , plus @entity4 ( @entity5 ) supplementation on high- @entity0 fed @entity2 . Quails were randomly divided into four groups. Group one (n = 25) fed experimental diet only (control; contained basal diet supplemented with 1% @entity0 ), group 2 (n = 20) fed experimental diet supplemented with @entity5 only (400 microg kg(-1) of body weight), groups 3 and 4 (n = 30 per group) were fed experimental diet supplemented with either 0.5% (w/w) of extracted @entity3 plus @entity5 or pure standard @entity3 (0.5%) plus @entity5 respectively, for 12 days. Blood samples were collected at days 0 and 12 for measuring levels of lipid profile. The work was carried out at Applied Science University and Amman University, Amman, Jordan during the period from October 2009 through October 2010. The mean levels of total @entity0 (TC) in control quails at d12 was significantly (p < 0.01) increased compare to those at d0. Supplementation of diet with @entity5 alone or @entity5 with @entity3 either extracted or pure standard for 12 days showed a significant (p < 0.01) decrease in TC and low density lipoprotein @entity0 (LDL-C) levels as compared to those in the control quails. While, high density lipoprotein @entity0 (HDL-C) increased significantly (p < 0.01) in quails supplemented with @entity3 and @entity5 . At d12, the mean @entity1 Dismutase (SOD) activities in erythrocytes of quails in all supplemented groups was significantly (p < 0.01) increased as compared to those in control group and was more pronounced in erythrocytes of quails supplemented with pure standard @entity3 plus @entity5 . These results indicated that the combined @entity3 and @entity5 supplementation to high- @entity0 fed quails might induce a protective effect by both regulating lipid and antioxidative damage.

title: The hypocholesterolemic and antioxidative effect of dietary XXXX and @entity4 supplementation on high- @entity0 fed @entity2 .

answer: @entity3


abstract: The current study investigated the effect of natural @entity3 extracted from fenugreek seeds, in comparison with the pure standard @entity3 , plus @entity4 ( @entity5 ) supplementation on high- @entity0 fed @entity2 . Quails were randomly divided into four groups. Group one (n = 25) fed experimental diet only (control; contained basal diet supplemented with 1% @entity0 ), group 2 (n = 20) fed experimental diet supplemented with @entity5 only (400 microg kg(-1) of body weight), groups 3 and 4 (n = 30 per group) were fed experimental diet supplemented with either 0.5% (w/w) of extracted @entity3 plus @entity5 or pure standard @entity3 (0.5%) plus @entity5 respectively, for 12 days. Blood samples were collected at days 0 and 12 for measuring levels of lipid profile. The work was carried out at Applied Science University and Amman University, Amman, Jordan during the period from October 2009 through October 2010. The mean levels of total @entity0 (TC) in control quails at d12 was significantly (p < 0.01) increased compare to those at d0. Supplementation of diet with @entity5 alone or @entity5 with @entity3 either extracted or pure standard for 12 days showed a significant (p < 0.01) decrease in TC and low density lipoprotein @entity0 (LDL-C) levels as compared to those in the control quails. While, high density lipoprotein @entity0 (HDL-C) increased significantly (p < 0.01) in quails supplemented with @entity3 and @entity5 . At d12, the mean @entity1 Dismutase (SOD) activities in erythrocytes of quails in all supplemented groups was significantly (p < 0.01) increased as compared to those in control group and was more pronounced in erythrocytes of quails supplemented with pure standard @entity3 plus @entity5 . These results indicated that the combined @entity3 and @entity5 supplementation to high- @entity0 fed quails might induce a protective effect by both regulating lipid and antioxidative damage.

title: The hypocholesterolemic and antioxidative effect of dietary @entity3 and XXXX supplementation on high- @entity0 fed @entity2 .

answer: @entity4


abstract: The current study investigated the effect of natural @entity3 extracted from fenugreek seeds, in comparison with the pure standard @entity3 , plus @entity4 ( @entity5 ) supplementation on high- @entity0 fed @entity2 . Quails were randomly divided into four groups. Group one (n = 25) fed experimental diet only (control; contained basal diet supplemented with 1% @entity0 ), group 2 (n = 20) fed experimental diet supplemented with @entity5 only (400 microg kg(-1) of body weight), groups 3 and 4 (n = 30 per group) were fed experimental diet supplemented with either 0.5% (w/w) of extracted @entity3 plus @entity5 or pure standard @entity3 (0.5%) plus @entity5 respectively, for 12 days. Blood samples were collected at days 0 and 12 for measuring levels of lipid profile. The work was carried out at Applied Science University and Amman University, Amman, Jordan during the period from October 2009 through October 2010. The mean levels of total @entity0 (TC) in control quails at d12 was significantly (p < 0.01) increased compare to those at d0. Supplementation of diet with @entity5 alone or @entity5 with @entity3 either extracted or pure standard for 12 days showed a significant (p < 0.01) decrease in TC and low density lipoprotein @entity0 (LDL-C) levels as compared to those in the control quails. While, high density lipoprotein @entity0 (HDL-C) increased significantly (p < 0.01) in quails supplemented with @entity3 and @entity5 . At d12, the mean @entity1 Dismutase (SOD) activities in erythrocytes of quails in all supplemented groups was significantly (p < 0.01) increased as compared to those in control group and was more pronounced in erythrocytes of quails supplemented with pure standard @entity3 plus @entity5 . These results indicated that the combined @entity3 and @entity5 supplementation to high- @entity0 fed quails might induce a protective effect by both regulating lipid and antioxidative damage.

title: The hypocholesterolemic and antioxidative effect of dietary @entity3 and @entity4 supplementation on high- XXXX fed @entity2 .

answer: @entity0


abstract: The current study investigated the effect of natural @entity3 extracted from fenugreek seeds, in comparison with the pure standard @entity3 , plus @entity4 ( @entity5 ) supplementation on high- @entity0 fed @entity2 . Quails were randomly divided into four groups. Group one (n = 25) fed experimental diet only (control; contained basal diet supplemented with 1% @entity0 ), group 2 (n = 20) fed experimental diet supplemented with @entity5 only (400 microg kg(-1) of body weight), groups 3 and 4 (n = 30 per group) were fed experimental diet supplemented with either 0.5% (w/w) of extracted @entity3 plus @entity5 or pure standard @entity3 (0.5%) plus @entity5 respectively, for 12 days. Blood samples were collected at days 0 and 12 for measuring levels of lipid profile. The work was carried out at Applied Science University and Amman University, Amman, Jordan during the period from October 2009 through October 2010. The mean levels of total @entity0 (TC) in control quails at d12 was significantly (p < 0.01) increased compare to those at d0. Supplementation of diet with @entity5 alone or @entity5 with @entity3 either extracted or pure standard for 12 days showed a significant (p < 0.01) decrease in TC and low density lipoprotein @entity0 (LDL-C) levels as compared to those in the control quails. While, high density lipoprotein @entity0 (HDL-C) increased significantly (p < 0.01) in quails supplemented with @entity3 and @entity5 . At d12, the mean @entity1 Dismutase (SOD) activities in erythrocytes of quails in all supplemented groups was significantly (p < 0.01) increased as compared to those in control group and was more pronounced in erythrocytes of quails supplemented with pure standard @entity3 plus @entity5 . These results indicated that the combined @entity3 and @entity5 supplementation to high- @entity0 fed quails might induce a protective effect by both regulating lipid and antioxidative damage.

title: The hypocholesterolemic and antioxidative effect of dietary @entity3 and @entity4 supplementation on high- @entity0 fed XXXX .

answer: @entity2


abstract: OBJECTIVES: To develop a cost-offset model from a US payer perspective comparing @entity3 and costs among @entity1 ( @entity1 ) @entity0 using bimatoprost, latanoprost, or travoprost. STUDY DESIGN: Cost-offset model. METHODS: A Markov cohort model was used to estimate @entity3 for @entity1 @entity0 over 7 years. The model assumed bimatoprost-treated @entity0 had lower resulting intraocular pressure (IOP) (by 1 mm Hg) for all presenting IOP categories than latanoprost- or travoprost-treated @entity0 . @entity0 with lower IOP were assumed to have lower probability of progression. Those that progressed were assumed to do so at a rate of -0.6 dB per year. Direct costs associated with mean deviation score categories were applied to each treatment cohort to calculate the expected 7-year costs of treating @entity0 with each @entity4 analogue ( @entity5 ). Literature was used to support assumptions. A budget impact analysis was conducted where all travoprost @entity0 switched to generic latanoprost and where all bimatoprost @entity0 switched to generic latanoprost. The base case market share was 22% bimatoprost, 23% travoprost, and 55% latanoprost. RESULTS: Model results demonstrate that for a managed care plan with 9500 @entity5 -treated @entity2 @entity0 , exclusive bimatoprost use would prevent progression in 136 additional individuals compared with exclusive travoprost or latanoprost treatment. Model results demonstrate that greater IOP reduction from bimatoprost is associated with increased cost savings compared with latanoprost or travoprost treatments. CONCLUSIONS: Model results demonstrate that greater IOP reduction from bimatoprost could reduce managed care spending.

title: Cost-offset analysis: bimatoprost versus other XXXX analogues in open-angle glaucoma.

answer: @entity4