abstract: Despite the high efficiency of ionizing radiation (IR) to inactivate @entity1 in general, an appreciable number of individual @entity0 cannot be cured by standard IR. @entity2 are not likely to be cured even by high-dose radiotherapy or chemotherapy. Accordingly, combined therapy is one of the most applicable strategies. Topoisomerase IIa is a ubiquitous enzyme that removes knots and tangles from the genetic material by generating and subsequently resealing of transient double-strand breaks. Due to its unique mechanism of action, topoisomerase IIa is the target of many chemotherapeutic agents such as @entity4 . The aim of the present study is to examine the effect of inhibiting topoisomerase IIa by @entity4 on the response of @entity3 to IR. Results of the present study demonstrated a radiosensitizing effect for the topoisomerase IIa inhibitor @entity4 on exponentially growing @entity3 ( @entity0 ) cell line especially at low radiation doses. This effect was found to be due to inhibition, by @entity4 , of the repair of radiation-induced DNA damage. Cell cycle studies showed that the concentration of @entity4 that sensitized the cells to radiation had no effect on the distribution of cells at different phases of the cell cycle. Synchronization of @entity0 cells in different cell cycle phases revealed that proliferating G1 and G2 cells are responsible for sensitization of cells at low doses of ionizing radiation. It might, therefore, be concluded that topoisomerase II enzyme may be involved in the repair of radiation-induced DNA damage and consequently its inhibition constitute a strategy for sensitizing @entity1 cells to ionizing radiation.

title: Inhibition of topoisomerase IIa sensitizes XXXX cells to ionizing radiation by diminishing DNA repair.

answer: @entity0


abstract: BACKGROUND: In @entity2 , @entity1 are a negative prognostic factor for survival and quality of life. Transcatheter arterial chemoembolization (TACE) is thought to be an effective symptomatic and antiproliferative treatment in @entity0 with otherwise progressive disease. METHODS: 62 chemoembolization procedures in 26 @entity0 with progressive @entity2 were reviewed. The underlying disease was @entity5 in 10, @entity2 in 2, @entity3 in 7, @entity2 in 2 @entity0 , @entity2 of the stomach in 1 and of unknown origin in 4 @entity0 . Tumor burden of the liver was <25% in 3, 25-50% in 11, 50-75% in 6 and >75% in 6 @entity0 . RESULTS: TACE was technically successful in 57 cases. Four @entity0 developed minor and 5 major complications. The 30-day mortality rate was 7.7%. According to WHO criteria, 14 @entity0 had no change in @entity2 burden, 2 had regression and 5 progress after chemoembolization. @entity0 with a @entity2 burden >75% of the liver did not benefit from TACE due to the development of major complications, whereas @entity0 with low (<50%) @entity2 burden and high (>50%) lipiodol uptake showed a trend towards longer survival. Five-year survival time after diagnosis was 48%. @entity0 treated with @entity4 and/or alpha-interferon had no benefit from chemoembolization with regard to their @entity5 . CONCLUSIONS: In this retrospective study, @entity0 with low (<50%) @entity2 burden and high (>50%) lipiodol uptake responded better to TACE than end-stage @entity0 .

title: Transarterial chemoembolization of advanced liver XXXX of @entity2 --a retrospective single-center analysis.

answer: @entity1


abstract: BACKGROUND: In @entity2 , @entity1 are a negative prognostic factor for survival and quality of life. Transcatheter arterial chemoembolization (TACE) is thought to be an effective symptomatic and antiproliferative treatment in @entity0 with otherwise progressive disease. METHODS: 62 chemoembolization procedures in 26 @entity0 with progressive @entity2 were reviewed. The underlying disease was @entity5 in 10, @entity2 in 2, @entity3 in 7, @entity2 in 2 @entity0 , @entity2 of the stomach in 1 and of unknown origin in 4 @entity0 . Tumor burden of the liver was <25% in 3, 25-50% in 11, 50-75% in 6 and >75% in 6 @entity0 . RESULTS: TACE was technically successful in 57 cases. Four @entity0 developed minor and 5 major complications. The 30-day mortality rate was 7.7%. According to WHO criteria, 14 @entity0 had no change in @entity2 burden, 2 had regression and 5 progress after chemoembolization. @entity0 with a @entity2 burden >75% of the liver did not benefit from TACE due to the development of major complications, whereas @entity0 with low (<50%) @entity2 burden and high (>50%) lipiodol uptake showed a trend towards longer survival. Five-year survival time after diagnosis was 48%. @entity0 treated with @entity4 and/or alpha-interferon had no benefit from chemoembolization with regard to their @entity5 . CONCLUSIONS: In this retrospective study, @entity0 with low (<50%) @entity2 burden and high (>50%) lipiodol uptake responded better to TACE than end-stage @entity0 .

title: Transarterial chemoembolization of advanced liver @entity1 of XXXX --a retrospective single-center analysis.

answer: @entity2


abstract: OBJECTIVE: To evaluate the potential roles of MR perfusion weighted imaging (PWI) in preoperative assessment of vascularity of @entity2 . METHODS: 9 @entity0 with @entity2 underwent conventional MR and PWI before operation (Grade I 32 cases, Grade II + III 7 cases). Immunohistochemical stain methods were used to quantitatively measure the microvessel density (MVD) values in @entity2 after operation. The pulse sequence of PWI was single shot GRE-EPI-T2(*)WI, the cerebral blood volume (CBV) maps were calculated from the original data of perfusion images and the maximum CBV values of @entity2 was acquired from CBV maps through measurement on the region of interest (ROI). The mean maximal relative cerebral blood volume (rCBV) values were calculated by dividing the maximum CBV of a @entity1 by that of the contralateral white matter. The differences of the mean maximal rCBV values between benign and malignant groups were analysed and commpared with the MVD values. RESULTS: The mean maximal rCBV values of benign and malignant groups were 9.76    4.68 and 3.57    0.27, respectively. The MVD values of benign and malignant groups were 22    12 and 11    5, respectively. The difference in mean maximal rCBV values between the two groups was statistically significant (t = 7.166, P < 0.01). Correlation analysis demonstrated that the mean maximal rCBV values and MVD values had significantly positive correlation (r = 0.715, P < 0.01). CONCLUSION: The mean maximal rCBV values are feasible for evaluation of microvessel angiogenesis of @entity2 in vivo and useful for predicting @entity1 grade.

title: [Evaluation of XXXX vessel of cerebral meningiomas with MR perfusion weighted imaging].

answer: @entity1


abstract: Our aim was to explore the current spectrum of contact allergens in schoolchildren, as a basis for diagnosis and prevention of @entity6 . Results of patch tests in @entity0 6-15 years old, performed in the years 1990-1995 by 22 centres of the German Contact @entity4 Research Group and filed by the Information Network of Departments of Dermatology, were analysed and evaluated retrospectively, including epidemiologic data. @entity0 with positive tests (62 out of 156 @entity0 and 108 out of 260 @entity0 tested) had a higher frequency of @entity6 and a lower frequency of @entity2 than patch test negative ones. 16 distinct allergens elicited positive reactions in > or = 1% of the @entity0 tested. Reactions to @entity7 occurred in 15.9% of all @entity0 tested, but in 25.0% of @entity0 14/15 years old, and in only 4.5% of @entity0 6-13 years old. Double-sensitizations with @entity10 , @entity9 and @entity8 were seen. @entity1 compounds were found in 2nd place (thimerosal: all @entity0 : 11.3%; 6-13 years old: 14.3%; 14/15 years old: 8.0%), followed by fragrance allergens. We conclude that contact @entity3 in @entity0 is related to their sex and age. Prophylaxis against @entity5 , @entity1 , and fragrance @entity3 needs to be improved. A shortened standard series may be sufficient for testing @entity0 .

title: Patch test results in schoolchildren. Results from the Information Network of Departments of Dermatology (IVDK) and the German Contact XXXX Research Group (DKG)

answer: @entity4


abstract: OBJECTIVE: To survey the acceptance and willingness-to-pay for @entity2 colonoscopy screening among high risk populations in urban China. METHODS: From 2012 to 2013, a @entity1 Screening Program in Urban China (CanSPUC) was initiated in 9 provinces, the current survey was conducted among those @entity0 who were evaluated as "high risk for @entity2 " by a risk-factor-evaluation-model (community-based) and then went through a colonoscopy screening procedure (hospital-based). All the data were obtained through a questionnaire-based interview (face-to-face or self-completed), mainly focusing on the acceptance and willingness-to-pay of the @entity0 for colorectal colonoscopy screening. RESULTS: The current analysis included a total of 1 624 @entity0 , with an median age of 55.0 years ( @entity5 = 49.0, @entity3 = 61.0 years) and an annual income per capita of 17 thousand (range: 10-25 thousand) Chinese Yuan (CNY), 42.8% (695/1 624) of whom were males. Of all the @entity0 , 87.0% (1 414/1 624) could totally or substantially accept the colonoscopy screening, particularly in those at higher education level (junior high school: OR = 0.34, 95% CI: 0.22-0.52; high school OR = 0.41, 95% CI: 0.26-0.66; college or over OR = 0.35, 95% CI: 0.20-0.59). Of all the @entity0 , 13.0% (210/1 624) could not or hardly accept it, particularly in those with older age (60-69 years) (OR = 1.48, 95% CI: 1.06-2.07), not in marriage (OR = 2.15, 95% CI: 1.25-3.70) or with family member(s) to raise (OR = 1.60, 95% CI: 1.17-2.20). 1 388 (85.5%) of all the @entity0 had willingness-to-pay for a long-term colonoscopy screening service, particularly in those working in public (OR = 0.61, 95% CI: 0.44-0.84) or enterprise sectors (OR = 0.60, 95% CI: 0.38-0.94), but 82.3% (1 141/1 386) of whom would only pay less than 100 CNY; 14.5% (236/1 624) of total had no willingness-to-pay, particularly in those living in areas with moderate (OR = 4.08, 95% CI: 2.75-6.33) or high @entity4 per capita (OR = 3.26, 95% CI: 2.11-4.92), or with an absence of willingness-to-pay for colonoscopy screening (OR = 3.98, 95% CI: 2.81-5.65). CONCLUSIONS: Although a larger community-based @entity2 screening program was warranted to examine the extrapolation of these findings, it suggested that the acceptance for @entity2 colonoscopy screening among the selected high-risk populations was considerable. The willing-to-pay was relatively high but the amount of payment was limited, the indicated subgroups with potentially less acceptance or willingness need to be more focused in the future to reach a higher participation rate. The data will also be informative in integrating the screening service into the local health insurance system.

title: [Acceptance and willingness-to-pay for colorectal colonoscopy screening among high-risk populations for XXXX in urban China].

answer: @entity2


abstract: @entity10 ( @entity10 ) is an autosomal-dominant @entity11 involving the skin, brain, kidney, heart and other organs. Renal manifestations are @entity6 , @entity2 and @entity1 . We report three female @entity0 , mean aged of 31 years (range: 22-37), with a family history of @entity10 in one case. @entity3 were found in all @entity0 . Clinical complaints were mainly abdominal @entity4 (3 cases), @entity7 (2 cases), right flank palpable mass (1 case). @entity6 ( @entity6 ) were diagnosed by ultrasonography in all @entity0 , associated to @entity2 in one case. A @entity0 underwent total right nephrectomy without any event during the follow-up. In a second @entity0 , a selective arterial embolization of @entity6 was indicated. Total left nephrectomy was performed due to the persistence of @entity7 and the @entity8 . Pathological examination of the kidney revealed @entity9 . The third @entity0 with small @entity6 , associated with @entity2 , required careful monitoring. Renal manifestations in @entity10 are frequent and serious, they are the second leading cause of @entity5 after nervous lesions. Clinical and morphological aspects are variable and different therapeutic indications must be discussed.

title: Renal manifestations of XXXX complex.

answer: @entity10


abstract: Experimental melanin protein-induced @entity3 (EMIU) is reported to be a model of anterior @entity3 and @entity4 in which the retina is spared. In this study, we chose to compare EMIU with experimental autoimmune @entity6 (EAU), a well-recognised model of @entity8 , with regard to the nature and dynamics of the cellular infiltrate in the iris. Female Lewis albino @entity0 were immunised with mixtures of crude retinal extract/complete Freund's adjuvant ( @entity5 ) ( @entity7 ), @entity2 -buffered saline/ @entity5 (controls), or iris melanin/ @entity5 (EMIU) using established protocols. Animals were sacrificed on days 10 and 13 (around disease onset). Following whole body perfusion fixation, irides were dissected from the remainder of the globe. Iris wholemount preparations were then subjected to immunohistochemical analysis in order to investigate both the dynamics of infiltrating leukocytes and the effects of the inflammatory changes on resident immune cells in the iris. The nature of the cellular infiltrate in both EMIU and EAU models was essentially similar, namely there was a rich infiltrate of EDI+ mononuclear cells, Ox42+ neutrophils and T cells. Resident tissue macrophages (ED2+) were slightly below normal densities in the iris of EAU animals and marginally elevated in EMIU animals, MHC class II (Ia) staining, associated in the normal eye with dendritic cells (DC), was considerably elevated in EMIU. It is likely that this was due to both increased DC numbers and an influx of Ia+ exudate macrophages. No striking difference was found in the nature and phenotype of the cellular infiltrate in the iris at the onset of the disease in these two models of @entity3 (EAU and EMIU). This suggests that the @entity1 in both models represents non-specific changes secondary to cytokine release associated with interaction of activated antigen-specific T cells and target antigens, namely retinal photoreceptors in EAU and uveal tract melanin-containing cells in EMIU. Alternatively, it may suggest that antigen-presenting cells resident in the iris and ciliary body in normal eyes have access to ocular antigens on both sides of the blood-ocular barrier and are capable of activating circulating antigen-specific T cells in these models.

title: Resident and infiltrating cells in the @entity0 iris during the early stages of experimental melanin protein-induced XXXX (EMIU).

answer: @entity3


abstract: Experimental melanin protein-induced @entity3 (EMIU) is reported to be a model of anterior @entity3 and @entity4 in which the retina is spared. In this study, we chose to compare EMIU with experimental autoimmune @entity6 (EAU), a well-recognised model of @entity8 , with regard to the nature and dynamics of the cellular infiltrate in the iris. Female Lewis albino @entity0 were immunised with mixtures of crude retinal extract/complete Freund's adjuvant ( @entity5 ) ( @entity7 ), @entity2 -buffered saline/ @entity5 (controls), or iris melanin/ @entity5 (EMIU) using established protocols. Animals were sacrificed on days 10 and 13 (around disease onset). Following whole body perfusion fixation, irides were dissected from the remainder of the globe. Iris wholemount preparations were then subjected to immunohistochemical analysis in order to investigate both the dynamics of infiltrating leukocytes and the effects of the inflammatory changes on resident immune cells in the iris. The nature of the cellular infiltrate in both EMIU and EAU models was essentially similar, namely there was a rich infiltrate of EDI+ mononuclear cells, Ox42+ neutrophils and T cells. Resident tissue macrophages (ED2+) were slightly below normal densities in the iris of EAU animals and marginally elevated in EMIU animals, MHC class II (Ia) staining, associated in the normal eye with dendritic cells (DC), was considerably elevated in EMIU. It is likely that this was due to both increased DC numbers and an influx of Ia+ exudate macrophages. No striking difference was found in the nature and phenotype of the cellular infiltrate in the iris at the onset of the disease in these two models of @entity3 (EAU and EMIU). This suggests that the @entity1 in both models represents non-specific changes secondary to cytokine release associated with interaction of activated antigen-specific T cells and target antigens, namely retinal photoreceptors in EAU and uveal tract melanin-containing cells in EMIU. Alternatively, it may suggest that antigen-presenting cells resident in the iris and ciliary body in normal eyes have access to ocular antigens on both sides of the blood-ocular barrier and are capable of activating circulating antigen-specific T cells in these models.

title: Resident and infiltrating cells in the XXXX iris during the early stages of experimental melanin protein-induced @entity3 (EMIU).

answer: @entity0


abstract: OBJECTIVE: To report the development of unexpected radiographic lucency (URL) corresponding to the use of a commercially available @entity2 / @entity4 composite used to treat @entity1 . MATERIALS AND METHODS: This is a retrospective comparative study of @entity0 with and without URL after treatment with curettage and grafting with @entity2 / @entity4 . The charts of 87 @entity0 meeting the inclusion criteria were reviewed for demographic, clinical, and radiographic data. The group with URL was compared to those with more typical patterns of graft incorporation. RESULTS: Thirteen of 87 cases (15  %) showed URL. There was no difference with respect to the pathologic subtype, anatomic location, or specific bone for the presence of URL. Of @entity0 with URL, one (7.7  %) required reoperation and regrafting, whereas among @entity0 without URL, five (6.7  %) had clinical complications, with one requiring reoperation and regrafting, and one requiring radiofrequency ablation. CONCLUSIONS: The majority of @entity0 treated with @entity2 / @entity4 cementing after curettage of low-grade @entity3 go on to uneventful healing in our series. In a minority of @entity0 , URL occurs in lieu of the more typical pattern of centripetal incorporation. However, there is no increase in complications associated with URL. Based on these findings, @entity0 should be informed of the possibility of this risk, although there appears to be little risk of clinically relevant adverse consequences. Physicians should be aware of this complication in order to avoid mistaking it for recurrence of the @entity1 .

title: Unexpected radiographic lucency following grafting of @entity3 with XXXX / @entity4 bone substitute.

answer: @entity2


abstract: OBJECTIVE: To report the development of unexpected radiographic lucency (URL) corresponding to the use of a commercially available @entity2 / @entity4 composite used to treat @entity1 . MATERIALS AND METHODS: This is a retrospective comparative study of @entity0 with and without URL after treatment with curettage and grafting with @entity2 / @entity4 . The charts of 87 @entity0 meeting the inclusion criteria were reviewed for demographic, clinical, and radiographic data. The group with URL was compared to those with more typical patterns of graft incorporation. RESULTS: Thirteen of 87 cases (15  %) showed URL. There was no difference with respect to the pathologic subtype, anatomic location, or specific bone for the presence of URL. Of @entity0 with URL, one (7.7  %) required reoperation and regrafting, whereas among @entity0 without URL, five (6.7  %) had clinical complications, with one requiring reoperation and regrafting, and one requiring radiofrequency ablation. CONCLUSIONS: The majority of @entity0 treated with @entity2 / @entity4 cementing after curettage of low-grade @entity3 go on to uneventful healing in our series. In a minority of @entity0 , URL occurs in lieu of the more typical pattern of centripetal incorporation. However, there is no increase in complications associated with URL. Based on these findings, @entity0 should be informed of the possibility of this risk, although there appears to be little risk of clinically relevant adverse consequences. Physicians should be aware of this complication in order to avoid mistaking it for recurrence of the @entity1 .

title: Unexpected radiographic lucency following grafting of @entity3 with @entity2 / XXXX bone substitute.

answer: @entity4


abstract: OBJECTIVE: To report the development of unexpected radiographic lucency (URL) corresponding to the use of a commercially available @entity2 / @entity4 composite used to treat @entity1 . MATERIALS AND METHODS: This is a retrospective comparative study of @entity0 with and without URL after treatment with curettage and grafting with @entity2 / @entity4 . The charts of 87 @entity0 meeting the inclusion criteria were reviewed for demographic, clinical, and radiographic data. The group with URL was compared to those with more typical patterns of graft incorporation. RESULTS: Thirteen of 87 cases (15  %) showed URL. There was no difference with respect to the pathologic subtype, anatomic location, or specific bone for the presence of URL. Of @entity0 with URL, one (7.7  %) required reoperation and regrafting, whereas among @entity0 without URL, five (6.7  %) had clinical complications, with one requiring reoperation and regrafting, and one requiring radiofrequency ablation. CONCLUSIONS: The majority of @entity0 treated with @entity2 / @entity4 cementing after curettage of low-grade @entity3 go on to uneventful healing in our series. In a minority of @entity0 , URL occurs in lieu of the more typical pattern of centripetal incorporation. However, there is no increase in complications associated with URL. Based on these findings, @entity0 should be informed of the possibility of this risk, although there appears to be little risk of clinically relevant adverse consequences. Physicians should be aware of this complication in order to avoid mistaking it for recurrence of the @entity1 .

title: Unexpected radiographic lucency following grafting of XXXX with @entity2 / @entity4 bone substitute.

answer: @entity3


abstract: The excitable gap of a reentrant circuit has both temporal (time during the cycle length that the circuit is excitable) and spatial (length of the circuit that is excitable at a given time) properties. We determined the temporal and spatial properties of the excitable gap in reentrant circuits caused by nonuniform anisotropy. @entity1 was produced in @entity0 hearts by ligation of the left anterior descending coronary artery. Four days later, reentrant circuits were mapped in the epicardial border zone of the @entity4 with a multielectrode array during sustained @entity3 induced by programmed stimulation. During @entity2 , premature impulses were initiated by stimulation at sites around and in the reentrant circuits, and their conduction characteristics in the circuit were mapped. All circuits had a temporal excitable gap in at least part of the circuit, which allowed premature impulses to enter the circuit. Completely and partially excitable segments of the temporal gap were identified by measuring conduction velocity of the premature impulses; conduction was equal to the native reentrant wave front in completely excitable regions and slower than the reentrant wave front in partially excitable regions. In some circuits, a temporal gap existed throughout the circuit, permitting the entire circuit to be reset over a range of premature coupling intervals, although the size of the gap varied at different sites. In other circuits, the gap became so small at local sites that even though premature impulses could enter the circuit, the circuit could not be reset. Premature impulses could terminate reentry in circuits that could be reset or not. We also found a significant spatial gap, which was identified by determining the distance between the head of the circulating wave front, which could be located on the activation map, and its tail, which was the site most distal from the head as located by the site of entry of the premature wave front into the circuit. The spatial gap could also vary in different parts of the circuit. Therefore, nonuniform anisotropic reentrant circuits have both a temporal and spatial excitable gap with fully and partially excitable components that change in different parts of the circuit.

title: Characteristics of the temporal and spatial excitable gap in anisotropic reentrant circuits causing sustained XXXX .

answer: @entity3


abstract: The @entity0 @entity5 subfamily of cytochrome P450 consists of @entity1 - and drug-metabolizing enzymes inducible by @entity6 and by supra-physiological doses of @entity2 . The induction of @entity5 by @entity2 has been proposed to be mediated by a mechanism distinct from the glucocorticoid receptor mediated response. However, a synergistic induction of @entity5 has been observed with physiological doses of glucocorticoids and other @entity5 inducers. We have identified the presence of a glucocorticoid-responsive element in the @entity4 /IGC2 gene that mediates the induction with physiological doses of glucocorticoids. A 219-bp @entity2 responsive fragment of the @entity4 /IGC2 gene localized at -2100/-1882 bp upstream of the transcription initiation site was identified in transfection experiments with HepG2 cells. Maximum induction was achieved with 50-100 nM @entity2 . @entity3 footprinting analysis revealed two glucocorticoid receptor-protected sequences in the 5' flank of the @entity4 /IGC2 gene. Point mutations in footprint I (-1982/-1960-bp) completely abolished binding and transcription activation whereas a mutation in footprint II (-2001/-1986-bp) only decreased the binding and had no effect on transcription activation. These results led to the conclusion that the glucocorticoid response element present in footprint I mediated the @entity2 response in transfection experiments with HepG2 cells. @entity6 failed to induce any transcriptional effect mediated by this response element in the HepG2 cells.

title: Identification of a functional glucocorticoid response element in the XXXX /IGC2 gene.

answer: @entity4


abstract: LYMFASIM, a microsimulation model for transmission and control of @entity2 , was used to simulate the effects of mass treatment, in order to estimate the number of treatment rounds necessary to achieve elimination. Simulations were performed for a community that represented Pondicherry, India, and that had an average precontrol microfilariae (MF) prevalence of 8.5%. When ivermectin was used, 8 yearly treatment rounds with 65% population coverage gave a 99% probability of elimination. The number of treatment rounds necessary to achieve elimination depended to a large extent on coverage, drug efficacy, and endemicity level. Changing the interval between treatment rounds mainly influenced the duration of control, not the number of treatment rounds necessary to achieve elimination. Results hardly changed with alternative assumptions regarding the type of immune mechanism. The potential impact of mass treatment with a combination of @entity4 and @entity1 is shown under different assumptions regarding its efficacy. @entity0 migration and drug resistance were not considered. Results cannot be directly generalized to areas with different vector or epidemiological characteristics. In conclusion, the prospects for elimination of @entity3 by mass treatment in Pondicherry seem good, provided that the level of population coverage is sufficiently high.

title: Prospects for elimination of XXXX by mass drug treatment in Pondicherry, India: a simulation study.

answer: @entity3


abstract: OBJECTIVE: We completed a prospective, randomized, double-blinded clinical trial to compare the quality of sedation with two @entity6 (emulsified @entity8 and @entity7 ) for endoscopic procedures. METHODS: Adult @entity0 undergoing esophagogastroduodenoscopy or colonoscopy were eligible. Exclusion criteria included: @entity1 , @entity5 , untreated @entity3 , active @entity4 , @entity2 , resident physician training, or cases done outside the Endoscopy unit. Nurses began the sedation process by administering an opioid followed immediately by administering study drugs until @entity0 were adequately sedated. At completion of the procedure, both the physician and the nurse rated whether the @entity0 's sedation appeared to be adequate. In addition, before discharge, @entity0 were asked to rate the quality of sedation. RESULTS: A total of 111 @entity0 were randomized to the emulsified @entity8 group and 100 to the @entity7 group. There was no difference in the physician's assessment of quality of sedation between the groups (p > 0.05). The length of time to sedation, total procedure time, and recovery time were similar between both groups. The estimated cost of using emulsified @entity8 was approximately 50% less than that of @entity7 , with an equal quality of sedation. CONCLUSION: Neither the physicians, nurses, nor the @entity0 could detect a difference between sedation produced by the drugs. We conclude that both drugs were equally effective for sedation for both upper and lower endoscopic procedures. Based on the results of this trial, we suggest that increased use of emulsified @entity8 would markedly reduce the cost without altering the quality of sedation. The cost savings would be at least  50,000/yr at our institution.

title: A randomized, prospective, double-blind comparison of @entity7 (Versed) and emulsified XXXX (Dizac) for opioid-based, conscious sedation in endoscopic procedures.

answer: @entity8


abstract: OBJECTIVE: We completed a prospective, randomized, double-blinded clinical trial to compare the quality of sedation with two @entity6 (emulsified @entity8 and @entity7 ) for endoscopic procedures. METHODS: Adult @entity0 undergoing esophagogastroduodenoscopy or colonoscopy were eligible. Exclusion criteria included: @entity1 , @entity5 , untreated @entity3 , active @entity4 , @entity2 , resident physician training, or cases done outside the Endoscopy unit. Nurses began the sedation process by administering an opioid followed immediately by administering study drugs until @entity0 were adequately sedated. At completion of the procedure, both the physician and the nurse rated whether the @entity0 's sedation appeared to be adequate. In addition, before discharge, @entity0 were asked to rate the quality of sedation. RESULTS: A total of 111 @entity0 were randomized to the emulsified @entity8 group and 100 to the @entity7 group. There was no difference in the physician's assessment of quality of sedation between the groups (p > 0.05). The length of time to sedation, total procedure time, and recovery time were similar between both groups. The estimated cost of using emulsified @entity8 was approximately 50% less than that of @entity7 , with an equal quality of sedation. CONCLUSION: Neither the physicians, nurses, nor the @entity0 could detect a difference between sedation produced by the drugs. We conclude that both drugs were equally effective for sedation for both upper and lower endoscopic procedures. Based on the results of this trial, we suggest that increased use of emulsified @entity8 would markedly reduce the cost without altering the quality of sedation. The cost savings would be at least  50,000/yr at our institution.

title: A randomized, prospective, double-blind comparison of XXXX (Versed) and emulsified @entity8 (Dizac) for opioid-based, conscious sedation in endoscopic procedures.

answer: @entity7


abstract: KEY MESSAGE: A new bacterial blight resistance gene has been identified through fine-mapping, which confers high levels of resistance to all Korean @entity2 . oryzae ( Xoo ) races, including the new Xoo race K3a. @entity0 @entity1 caused by @entity2 . oryzae (Xoo) is a serious constraint to @entity0 production in Asia and Africa. The japonica advanced backcross breeding lines derived from the indica line IR65482-7-216-1-2 in the background of cultivar Junam are resistant to all Korean BB races, including K3a. To identify the gene(s) involved in resistance to Korean Xoo races, the association of genotypic and phenotypic variations was examined in two F2 populations derived from the crosses between 11325 (IR83261-3-7-23-6-2-1-1-2-1-2)/Anmi and 11325/Ilpum. The segregation ratios of F2 individuals from the crosses of 11325/Anmi and 11325/Ilpum were 578 resistant:209 susceptible and 555 resistant:241 susceptible, respectively, which is consistent with the expected allelic frequency of a 3:1 ratio. Genetic analysis using graphical mapping indicated that resistance (R) was controlled by a new resistance gene linked with the flanking markers RM27320 and ID55.WA18-5 within an approximately 80-kb region between 28.14 and 28.22  Mbp on chromosome 11. The eight candidate genes functionally predicted were included in the target region. Examination of the candidate genes by RT-PCR analysis only corroborated with the significant difference in transcript levels of the WAK3 gene in the presence or absence of pathogen infection. Allelism tests performed with other known BB R-genes revealed that the allele was distinct from others having a similar chromosomal location.

title: Identification and fine-mapping of a new resistance gene, Xa40, conferring resistance to bacterial blight races in XXXX ( @entity0 .).

answer: @entity0


abstract: KEY MESSAGE: A new bacterial blight resistance gene has been identified through fine-mapping, which confers high levels of resistance to all Korean @entity2 . oryzae ( Xoo ) races, including the new Xoo race K3a. @entity0 @entity1 caused by @entity2 . oryzae (Xoo) is a serious constraint to @entity0 production in Asia and Africa. The japonica advanced backcross breeding lines derived from the indica line IR65482-7-216-1-2 in the background of cultivar Junam are resistant to all Korean BB races, including K3a. To identify the gene(s) involved in resistance to Korean Xoo races, the association of genotypic and phenotypic variations was examined in two F2 populations derived from the crosses between 11325 (IR83261-3-7-23-6-2-1-1-2-1-2)/Anmi and 11325/Ilpum. The segregation ratios of F2 individuals from the crosses of 11325/Anmi and 11325/Ilpum were 578 resistant:209 susceptible and 555 resistant:241 susceptible, respectively, which is consistent with the expected allelic frequency of a 3:1 ratio. Genetic analysis using graphical mapping indicated that resistance (R) was controlled by a new resistance gene linked with the flanking markers RM27320 and ID55.WA18-5 within an approximately 80-kb region between 28.14 and 28.22  Mbp on chromosome 11. The eight candidate genes functionally predicted were included in the target region. Examination of the candidate genes by RT-PCR analysis only corroborated with the significant difference in transcript levels of the WAK3 gene in the presence or absence of pathogen infection. Allelism tests performed with other known BB R-genes revealed that the allele was distinct from others having a similar chromosomal location.

title: Identification and fine-mapping of a new resistance gene, Xa40, conferring resistance to bacterial blight races in @entity0 ( XXXX .).

answer: @entity0


abstract: 1. Effect of a diet with 5% grape seed inclusion, substituting for @entity2 compared to a standard diet, was studied in the Penedes @entity1 . 2. A total of 128 @entity1 were used, half from each sex. Individual weights and feed intake were controlled weekly from the first d to 5th week and fortnightly until the 15th week. On the 16th week, chemical analyses of meat from 16 thighs from each diet and sex were carried out, as well as a sensory analysis of meat from 24 thighs. Differences between diet and sex were analysed using live body weight, feed intake, feed conversion rate ( @entity4 ), chemical composition and sensory attributes of the meat. 3. At the end of the experiment, no significant differences were observed on live body weight, feed intake and @entity4 due to diet. 4. Meat showed no differences due to diet in the percentages of protein, lipid and ash. 5. Meat from the grape seed diet showed a higher percentage of @entity0 due to @entity3 . It also showed a more nutty smell, a more metallic flavour and more stringiness. There was, also, less of a pork crackling odour and flavour, a less sweet flavour and less of a broiler meat flavour.

title: The effects of grape seed in the diet of the Penedes XXXX , on growth and on the chemical composition and sensory profile of meat.

answer: @entity1


abstract: BACKGROUND/AIMS: The purpose of this study was to evaluate the clinical utility of laparoscopic surgery for gastric @entity1 . METHODS: The records of 11 @entity0 who underwent laparoscopic wedge resection (LR group) for @entity4 were reviewed and compared with those of 8 @entity0 who underwent open surgery (OS group). RESULTS: Mean operation time was 145 +/- 43 min in the LR group and 127 +/- 33 min in the OS group (p = 0.301). Mean @entity2 was 97 +/- 107 and 107 +/- 47 g, respectively (p = 0.387). @entity0 in the LR group began walking 1.4 +/- 0.7 days after surgery, which was significantly earlier than those in the OS group (2.7 +/- 1.3 days, p = 0.021). The first flatus (1.5 +/- 0.5 vs. 3.1 +/- 0.6 days, respectively, p = 0.0004) and resumption of oral food intake (3.0 +/- 1.7 vs. 4.3 +/- 0.9 days, respectively, p = 0.020) were also earlier in the LR group. White blood cell count on the first postoperative day was lower (7,000 +/- 2,100 vs. 11,900 +/- 3,580/mm(3), respectively, p = 0.004) in the LR group than in the OS group, and the duration of @entity3 (>38.0 degrees C; 0.1 +/- 0.3 vs. 0.9 +/- 0.8 days, respectively, p = 0.014) and the period of postoperative hospitalization (13.2 +/- 3.7 vs. 20.8 +/- 6.1 days, respectively, p = 0.014) were significantly shorter in the LR group than in the OS group. No complications occurred in either group. CONCLUSION: Laparoscopic surgery was superior to open surgery in terms of postoperative recovery time with comparable operation time and @entity2 . Laparoscopic wedge resection is a promising surgical alternative for the treatment of @entity4 .

title: Laparoscopic wedge resection of XXXX .

answer: @entity4


abstract: OBJECTIVE: To determine the clinical outcomes of @entity0 with @entity7 ( @entity7 ). STUDY DESIGN: Inception cohorts of @entity0 with @entity7 were established at two tertiary pediatric centers. Outcome data were obtained through review of hospital charts, interview and examination of @entity0 , and completion of questionnaires by @entity0 . RESULTS: Of 45 eligible subjects, 23 (51%) were assessed. Median time since diagnosis was 13 years (range, 6-25). At evaluation, 6 (26%) had active disease; 18 (78%) had Health Assessment Questionnaire scores of 0 (no/minimal @entity4 ), and 5 had scores >0. Some impairment was seen in all domains of measurement of quality-of-life test, especially those concerning nonphysical aspects of health. Six (26%) subjects continued to have @entity2 as a result of @entity7 . Associated medical problems included @entity3 in 6, @entity8 in 3, @entity5 in 5, recurrent @entity6 in 2, and @entity1 in 3. CONCLUSIONS: Long-term clinical outcomes for @entity0 with @entity7 appear to be generally good, with most subjects having no evidence of disease activity or sequelae. However, a number of subjects had persistent disease and, therefore, remain at risk of physical and psychologic complications. Further research is required to identify @entity0 at risk for persistent disease, and to determine therapies that may prevent morbidity.

title: XXXX : clinical outcomes after more than five years of follow-up.

answer: @entity7


abstract: BACKGROUND: The rate of clearance of antileukemic agents differs by a factor of 3 to 10 among @entity0 with @entity1 . We hypothesized that the outcome of treatment would be improved if doses were individualized to prevent low systemic exposure to the drugs in @entity0 with fast drug clearance. METHODS: We stratified and randomly assigned 182 @entity0 with newly diagnosed @entity1 to postremission regimens that included high-dose @entity2 and @entity5 plus @entity4 . The doses of these drugs were based on body-surface area (in the conventional-therapy group) or the rates of clearance of the three medications in each @entity0 (in the individualized-treatment group). In the individualized-treatment group, doses were increased in @entity0 with rapid clearance and decreased in @entity0 with very slow clearance. RESULTS: @entity0 who received individualized doses had significantly fewer courses of treatment with systemic exposures below the target range than did @entity0 who received conventional doses (P<0.001 for each medication). Among the @entity0 with @entity6 , those who received individualized therapy had a significantly better outcome than those given conventional therapy (P=0.02); the mean (+/-SE) rates of continuous complete remission at five years were 76+/-6 percent and 66+/-7 percent, respectively. There was no significant difference between treatments for @entity0 with @entity3 (P=0.54). In a proportional-hazards model, the time-dependent systemic exposure to @entity2 , but not to @entity5 or @entity4 , was significantly related to the risk of early relapse in @entity0 with @entity6 . CONCLUSIONS: Adjusting the dose of @entity2 to account for the @entity0 's ability to clear the drug can improve the outcome in @entity0 with B-lineage @entity1 .

title: Conventional compared with individualized chemotherapy for childhood XXXX .

answer: @entity1


abstract: @entity9 ( @entity9 ) is a variant of a @entity3 with a tendency to higher frequency of @entity1 and a lower survival rate. However, intracavitary cardiac @entity1 from thyroid @entity9 are extremely rare. We describe the case of a 57-year-old female with thyroid @entity9 , 5 years after total thyroidectomy, who presented with @entity8 associated with @entity4 and @entity5 . The computed tomography angiogram showed @entity7 and a 6-cm right atrial mass while the lower-extremity @entity6 studies were negative. This @entity0 received a cardiac thrombectomy using cardiopulmonary bypass support. However, intraoperatively, we found out that the mass was from the mediastinum, directly extending into the heart and clearly unresectable since it effaced at least 1/3 of the right atrial wall. The core biopsy of the mass confirmed that it was metastatic poorly differentiated @entity9 of thyroidal origin. The @entity0 eventually died of @entity10 due to a massive @entity7 . For @entity2 @entity0 with unexplained @entity8 , cardiac @entity1 should be considered regardless of anticoagulation prophylaxis, especially when there is no @entity6 in the lower limbs. Early recognition of intracavitary cardiac @entity1 may help in providing prompt treatment and improving the prognosis.

title: A Rare Silent Killer: Right Atrial Metastasis of Thyroid H  rthle Cell XXXX .

answer: @entity3


abstract: PURPOSE/OBJECTIVES: To determine the relationship between contextual variables, emotional state, and quality of life (QOL) now and expectations for the future in survivors of @entity0 . DESIGN: Descriptive and nonexperimental. SETTING AND SAMPLE: 148 volunteers and @entity1 with @entity0 involved in a program by the American @entity2 Society. Most subjects were middle-aged (mean = 52.4, SD = 11.56), were married (72%), and had graduated high school (38%). Time since diagnosis was 0.3-19 years (mean = 3.54, SD = 3.61); 74% were diagnosed more than five years ago, 54% were not receiving any treatment, and 66% had localized @entity0 . METHODS: At home, @entity1 completed a self-report survey for personal and contextual variables, Positive and Negative Affect Scale, QOL Measurement, and Global Life Satisfaction Scale. MAIN RESEARCH VARIABLES: Time since diagnosis, extent of @entity2 , emotional state, QOL, and global life satisfaction. FINDINGS: @entity1 had high positive affect (mean = 37.96) and low negative affect (mean = 17.13). QOL and life satisfaction were high. Time since diagnosis and extent of disease were related weakly to negative affect and QOL (p < 0.001). Positive and negative affect were related moderately to QOL and life satisfaction (p < 0.001). Current personal life satisfaction was significantly greater than @entity0 survivors' estimates for "most @entity1 ," and survivors expected life satisfaction to increase significantly in five years (p < 0.001). Significant differences in QOL were found between those who were diagnosed recently and those who were diagnosed 10 or more years previously. CONCLUSIONS: Despite @entity0 , @entity1 have positive affect, good QOL, and life satisfaction. Contextual variables were related weakly to outcomes; emotions were related more strongly to outcomes. Survivors were more satisfied with life than they estimated others to be and expected satisfaction to increase in the future. IMPLICATIONS FOR NURSING: Nurses may use these findings to encourage @entity1 who are newly diagnosed with @entity0 . @entity1 with @entity0 adapt well despite potential negative outcomes, and survivors even report better QOL than they estimate for most @entity1 .

title: Contextual variables, emotional state, and current and expected quality of life in XXXX survivors.

answer: @entity0


abstract: The aim of the present paper is to review the scientific literature concerning the usefulness of @entity3 -FDG PET/CT in the evaluation of response to chemotherapy in @entity0 affected by liver @entity1 from @entity2 . Material and Methods. Studies were identified by searching PubMed electronic databases. Both prospective and retrospective studies were included. Information regarding the figure of merit of PET for the evaluation of therapy response was extracted and analyzed. Results. Existing data suggests that @entity3 -FDG PET/CT may have an outstanding role in evaluating the response. The sensitivity of PET in detecting therapy response seems to be greater than conventional imaging (CT and MRI). PET/CT response is strictly related to better overall survival and progression-free survival. Conclusions. PET/CT is more than a promising technique to assess the response to chemotherapy in colorectal and liver @entity1 . However, to be fully validated, this examination needs further studies by recruiting more @entity0 .

title: Positron Emission Tomography for the Response Evaluation following Treatment with Chemotherapy in XXXX Affected by Colorectal Liver Metastases: A Selected Review.

answer: @entity0


abstract: The feasibility and safety of the administration of multiple cycles of dose-intensive chemotherapy (CT) supported with repeated reinfusions of circulating progenitor cells (CPCs) were evaluated in a prospective study of adjuvant initial therapy of poor-prognosis @entity0 . Eighteen @entity1 with resectable @entity0 involving >/= 10 axillary nodes or >/= 5 axillary nodes and negativity of the @entity4 receptor status received a cycle of standard FEC regimen (5-FU 600 mg/m2, @entity5 60 mg/m2, @entity10 600 mg/m2, i.v. on day 1) followed by @entity6 as CPC mobilization technique. Collected CPCs were fractionated and reinfused, with @entity6 , after each of the 4 subsequent cycles of high-dose FEC ( @entity8 -FEC) ( @entity7 750 mg/m2, @entity5 120 mg/m2, @entity10 3 g/m2, i.v.) planned at 21 day intervals. The median numbers of @entity9 + cells and CFU-GM collected (with one or two leukaphereses per @entity1 ) were 9.7x10(6)/kg (range: 2.5-22.9) and 9.9x10(4)/kg (range: 1.9-27.3), respectively, and day 9 was the median first day of procedure (range: 8-12) after FEC. All @entity1 received the 4 courses of @entity8 -FEC (for a total of 72 cycles). Hemopoietic recovery was rapid after each cycle and there was no treatment-related delays in CT administration. @entity2 was the major non-hematological @entity3 . There were 2, 3, 7 and 9 episodes of WHO grade 3/4 @entity2 in cycles 1, 2, 3 and 4, respectively. These severe episodes lasted a median of 4 days (range: 2-6) but no @entity1 required parenteral nutrition. The mean +/- SD total hospital stay lasted 10 +/- 2 days. The delivery of 4 cycles of dose-intensive FEC CT supported by CPCs (mobilized with a single course of standard-dose FEC + @entity6 ) is feasible and safe. It could represent an effective alternative strategy to other more aggressive programs for the adjuvant therapy of high-risk early @entity0 .

title: Multicyclic dose-intensive chemotherapy with circulating progenitor cell support for high-risk primary XXXX .

answer: @entity0


abstract: @entity9 is a @entity1 -associated gene of the S-100 gene family and codes for a @entity4 -binding protein. It is highly expressed in @entity3 and @entity0 @entity2 of high invasive and metastatic potential. Recent work has shown that the @entity9 protein might be involved in cell cycle regulation. An upregulation of its expression drives cells into the S phase, together with an enhanced expression of @entity7 phosphoprotein, which has led to the suggestion that mtsl protein might be sequestering @entity7 thereby abrogating the G1-S checkpoint control normally exerted by @entity7 . Preliminary studies showed that expression of @entity9 is downregulated by @entity5 . We present evidence that in @entity3 BL6 @entity6 cells and @entity0 HUT cells that @entity5 downregulates the @entity9 gene. It is also downregulated in heat-resistant variants of the B16 @entity6 and HUT cells. In parallel, there is a decrease in the size of the S phase fraction and an increase in the doubling time of cells. Cell subjected to @entity5 show an 2- to 3.5-fold increase in the expression of @entity8 which has been shown to possess a proliferation inhibitory action. It is postulated that a complete regulatory loop involving mtsl, @entity7 , and @entity8 might be involved in cell proliferation.

title: Heat shock modulates the expression of the @entity1 associated gene MTS1 and proliferation of @entity3 and XXXX @entity2 cells.

answer: @entity0


abstract: @entity9 is a @entity1 -associated gene of the S-100 gene family and codes for a @entity4 -binding protein. It is highly expressed in @entity3 and @entity0 @entity2 of high invasive and metastatic potential. Recent work has shown that the @entity9 protein might be involved in cell cycle regulation. An upregulation of its expression drives cells into the S phase, together with an enhanced expression of @entity7 phosphoprotein, which has led to the suggestion that mtsl protein might be sequestering @entity7 thereby abrogating the G1-S checkpoint control normally exerted by @entity7 . Preliminary studies showed that expression of @entity9 is downregulated by @entity5 . We present evidence that in @entity3 BL6 @entity6 cells and @entity0 HUT cells that @entity5 downregulates the @entity9 gene. It is also downregulated in heat-resistant variants of the B16 @entity6 and HUT cells. In parallel, there is a decrease in the size of the S phase fraction and an increase in the doubling time of cells. Cell subjected to @entity5 show an 2- to 3.5-fold increase in the expression of @entity8 which has been shown to possess a proliferation inhibitory action. It is postulated that a complete regulatory loop involving mtsl, @entity7 , and @entity8 might be involved in cell proliferation.

title: Heat shock modulates the expression of the XXXX associated gene MTS1 and proliferation of @entity3 and @entity0 @entity2 cells.

answer: @entity1


abstract: @entity9 is a @entity1 -associated gene of the S-100 gene family and codes for a @entity4 -binding protein. It is highly expressed in @entity3 and @entity0 @entity2 of high invasive and metastatic potential. Recent work has shown that the @entity9 protein might be involved in cell cycle regulation. An upregulation of its expression drives cells into the S phase, together with an enhanced expression of @entity7 phosphoprotein, which has led to the suggestion that mtsl protein might be sequestering @entity7 thereby abrogating the G1-S checkpoint control normally exerted by @entity7 . Preliminary studies showed that expression of @entity9 is downregulated by @entity5 . We present evidence that in @entity3 BL6 @entity6 cells and @entity0 HUT cells that @entity5 downregulates the @entity9 gene. It is also downregulated in heat-resistant variants of the B16 @entity6 and HUT cells. In parallel, there is a decrease in the size of the S phase fraction and an increase in the doubling time of cells. Cell subjected to @entity5 show an 2- to 3.5-fold increase in the expression of @entity8 which has been shown to possess a proliferation inhibitory action. It is postulated that a complete regulatory loop involving mtsl, @entity7 , and @entity8 might be involved in cell proliferation.

title: Heat shock modulates the expression of the @entity1 associated gene MTS1 and proliferation of @entity3 and @entity0 XXXX cells.

answer: @entity2


abstract: @entity9 is a @entity1 -associated gene of the S-100 gene family and codes for a @entity4 -binding protein. It is highly expressed in @entity3 and @entity0 @entity2 of high invasive and metastatic potential. Recent work has shown that the @entity9 protein might be involved in cell cycle regulation. An upregulation of its expression drives cells into the S phase, together with an enhanced expression of @entity7 phosphoprotein, which has led to the suggestion that mtsl protein might be sequestering @entity7 thereby abrogating the G1-S checkpoint control normally exerted by @entity7 . Preliminary studies showed that expression of @entity9 is downregulated by @entity5 . We present evidence that in @entity3 BL6 @entity6 cells and @entity0 HUT cells that @entity5 downregulates the @entity9 gene. It is also downregulated in heat-resistant variants of the B16 @entity6 and HUT cells. In parallel, there is a decrease in the size of the S phase fraction and an increase in the doubling time of cells. Cell subjected to @entity5 show an 2- to 3.5-fold increase in the expression of @entity8 which has been shown to possess a proliferation inhibitory action. It is postulated that a complete regulatory loop involving mtsl, @entity7 , and @entity8 might be involved in cell proliferation.

title: Heat shock modulates the expression of the @entity1 associated gene MTS1 and proliferation of XXXX and @entity0 @entity2 cells.

answer: @entity3


abstract: Local recurrence rates of approximately 30% have been consistently reported after 'conventional surgery' in stage II + III @entity1 @entity0 . Postoperative radiotherapy decreases the local recurrence rate only moderately and is not associated with a gain in survival. Preoperative radiotherapy with biologically effective doses > 30 Gy dramatically reduces the relative risk of local recurrences by 57% that translates into significant overall survival benefit. Postoperative @entity3 -based chemotherapy in combination with radiotherapy has also been shown to increase @entity1 control and to result in a significantly better survival. However, an improved surgical technique, the @entity2 ( @entity2 ), has evolved and is considered standard treatment by many surgeons. With this technique, reduced local recurrence rates of below 10% and improved survival rates have been reported from different institutions. Therefore, a discussion has started, whether or not pre- or postoperative radiotherapy and chemotherapy is beneficial, when @entity2 is used. The preliminary results of a recently published trial on radiotherapy before @entity2 partly resolve the current controversy. An expected local failure rate of approximately 15% and an overall survival rate below 60%, 5 years after @entity2 alone in stage II + III @entity1 @entity0 suggest the need for additional therapy. Preoperative radiotherapy reduced the risk of local recurrence more than 3 times, indicating that the use of radiotherapy is justified at least in @entity0 with @entity1 , even if optimal surgery was used. The unsatisfactory overall survival gives indirect evidence that these @entity0 will also benefit from chemotherapy. However, many questions remain open and an optimal therapeutic schedule has not been established.

title: New aspects of adjuvant radiotherapy in primarily resectable XXXX .

answer: @entity1


abstract: BACKGROUND: @entity4 -soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most @entity0 isolates. This study tested the hypothesis that in  vitro PSM production levels are associated with specific clinical phenotypes. METHODS: 177 @entity3 -resistant @entity0 ( @entity0 ) isolates from @entity1 ( @entity1 ), skin and soft tissue infection (SSTI), and @entity2 ( @entity2 ) were matched by geographic origin, then genotyped using spa-typing. In  vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal-Wallis tests as appropriate. RESULTS: Spa type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% @entity1 ; 16.9% @entity2 ; p  <  0.0001) while @entity2 and @entity1 isolates were more commonly spa type 2 (0% SSTI; 37.3% @entity1 ; 40.7% @entity2 ; p  <  0.0001). USA300 isolates produced the highest levels of PSMs in  vitro. SSTI isolates produced significantly higher quantities of PSMa1-4, PSMb1, and   -toxin than other isolates (p  <  0.001). These findings persisted when USA300 isolates were excluded from analysis. CONCLUSIONS: Increased in  vitro production of PSMs is associated with an SSTI clinical source. This significant association persisted after exclusion of USA300 genotype isolates from analysis, suggesting that PSMs play a particularly important role in the pathogenesis of SSTI as compared to other infection types.

title: Clinical XXXX isolates from skin and soft tissue infections show increased in  vitro production of @entity4 soluble modulins.

answer: @entity0


abstract: BACKGROUND: @entity4 -soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most @entity0 isolates. This study tested the hypothesis that in  vitro PSM production levels are associated with specific clinical phenotypes. METHODS: 177 @entity3 -resistant @entity0 ( @entity0 ) isolates from @entity1 ( @entity1 ), skin and soft tissue infection (SSTI), and @entity2 ( @entity2 ) were matched by geographic origin, then genotyped using spa-typing. In  vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal-Wallis tests as appropriate. RESULTS: Spa type 1 was significantly more common in SSTI isolates (62.7% SSTI; 1.7% @entity1 ; 16.9% @entity2 ; p  <  0.0001) while @entity2 and @entity1 isolates were more commonly spa type 2 (0% SSTI; 37.3% @entity1 ; 40.7% @entity2 ; p  <  0.0001). USA300 isolates produced the highest levels of PSMs in  vitro. SSTI isolates produced significantly higher quantities of PSMa1-4, PSMb1, and   -toxin than other isolates (p  <  0.001). These findings persisted when USA300 isolates were excluded from analysis. CONCLUSIONS: Increased in  vitro production of PSMs is associated with an SSTI clinical source. This significant association persisted after exclusion of USA300 genotype isolates from analysis, suggesting that PSMs play a particularly important role in the pathogenesis of SSTI as compared to other infection types.

title: Clinical @entity0 isolates from skin and soft tissue infections show increased in  vitro production of XXXX soluble modulins.

answer: @entity4


abstract: BACKGROUND: Recent studies have indicated the prognostic value of @entity2 subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the present study, we identified the prognostic factors for long-term outcome after NAC, considering that they could have an inconstant impact over time. METHODS: Prognostic factors from 956 consecutive @entity0 @entity1 treated with NAC were identified and associated with long-term outcomes. We estimated survival by a time function multivariate Cox model regression and stratified by follow-up length. RESULTS: The prognostic value of @entity2 histological grade and hormone receptors status varied as distant recurrence-free interval (DRFI) increased. The multivariate analysis identified the following significant prognostic factors: @entity2 size, N stage, clinical and pathological response to NAC, hormone receptors (HR) status and histological @entity2 grade. The 'prognostic benefit' of low-grade and positive-HR status decreased over the years. Thus, in the early years after @entity2 diagnosis, the hazard ratio of distant recurrences in @entity1 with positive-HR status increased from 0.26 (95% CI 0.1-0.4) at 6 months to 2.2 (95% CI 1.3-3.7) at 120 months. The histological @entity2 grade followed a similar trend. The hazard ratio of grade III @entity1 compared with grade I was 1.83 (95% CI 1.1-2.8) at 36 months and diminished over time to 0.70 (95% CI 0.4-1.3) at 120 months. This indicates that the risk of recurrence for positive-HR @entity1 was 74% lower at 6 months compared with the negative-hormone receptor group, but 30% higher at 5 years and more than double at 10 years. High-grade @entity2 presented a risk of 83% in the earlier years decreasing to 30% at 10 years versus the low-grade group. CONCLUSION: From the present study, we conclude the importance of identifying time-dependent prognostic factors. Distant recurrence-free interval within @entity1 who receive NAC are influenced by achieving pCR and @entity0 subtype. @entity2 with more aggressive biology have poorer survival during the first 5 years, but if they exceed this point their prognostic impact is no longer significant. Conversely, positive-HR @entity1 remain at risk for distant recurrence for many years.

title: Time-varying effect and long-term survival analysis in XXXX @entity1 treated with neoadjuvant chemotherapy.

answer: @entity0


abstract: BACKGROUND: Recent studies have indicated the prognostic value of @entity2 subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the present study, we identified the prognostic factors for long-term outcome after NAC, considering that they could have an inconstant impact over time. METHODS: Prognostic factors from 956 consecutive @entity0 @entity1 treated with NAC were identified and associated with long-term outcomes. We estimated survival by a time function multivariate Cox model regression and stratified by follow-up length. RESULTS: The prognostic value of @entity2 histological grade and hormone receptors status varied as distant recurrence-free interval (DRFI) increased. The multivariate analysis identified the following significant prognostic factors: @entity2 size, N stage, clinical and pathological response to NAC, hormone receptors (HR) status and histological @entity2 grade. The 'prognostic benefit' of low-grade and positive-HR status decreased over the years. Thus, in the early years after @entity2 diagnosis, the hazard ratio of distant recurrences in @entity1 with positive-HR status increased from 0.26 (95% CI 0.1-0.4) at 6 months to 2.2 (95% CI 1.3-3.7) at 120 months. The histological @entity2 grade followed a similar trend. The hazard ratio of grade III @entity1 compared with grade I was 1.83 (95% CI 1.1-2.8) at 36 months and diminished over time to 0.70 (95% CI 0.4-1.3) at 120 months. This indicates that the risk of recurrence for positive-HR @entity1 was 74% lower at 6 months compared with the negative-hormone receptor group, but 30% higher at 5 years and more than double at 10 years. High-grade @entity2 presented a risk of 83% in the earlier years decreasing to 30% at 10 years versus the low-grade group. CONCLUSION: From the present study, we conclude the importance of identifying time-dependent prognostic factors. Distant recurrence-free interval within @entity1 who receive NAC are influenced by achieving pCR and @entity0 subtype. @entity2 with more aggressive biology have poorer survival during the first 5 years, but if they exceed this point their prognostic impact is no longer significant. Conversely, positive-HR @entity1 remain at risk for distant recurrence for many years.

title: Time-varying effect and long-term survival analysis in @entity0 XXXX treated with neoadjuvant chemotherapy.

answer: @entity1


abstract: @entity13 affects both primary and permanent dentition. The purpose of this study was to examine the composition of subgingival microflora of the permanent dentition in an 11-year-old Caucasian female, who had premature exfoliation of her deciduous teeth on her 5th year of age, and the response of this condition to the antibiotic therapy and supportive periodontal care. Gingival tissues were highly inflamed and @entity3 was detected radiographically. The @entity0 had experienced frequent @entity5 , @entity12 and recurrent @entity6 . Her mother had history of early onset @entity7 associated with @entity11 . Blood chemistry tests and immunological examinations were also performed. @entity2 samples were collected from the proximal sites of permanent molars, incisors, @entity1 and maxillary premolars. 27 different microbial species were isolated from the subgingival microflora. Among the predominant species were @entity8 (17.6%-7.3%), @entity9 (12.4%-4.7%), @entity15 sputigena (14.4%-10.4%), @entity15 (13.2%-6.9%) and @entity10 (9.3%-5.5%). Periodontal treatment consisted of scaling, root planing in conjunction with antibiotic administration of @entity14 312.5 mg and @entity4 200 mg, each t.i.d. for 10 days. 3 weeks after the antibiotic therapy, bacterial samples were collected from the same sites. All the periodontal pathogens were recovered in lower levels and A.actinomycetemcomitans was almost eliminated in the 3-week period. The evaluation of clinical indices at 3, 6 and 12 months showed that periodontal treatment in conjunction with antibiotics was effective and rapidly followed by marked clinical improvement. The microbiological monitoring at 3, 6 and 12 months after antibiotic treatment and each time prior to supportive periodontal care, revealed that the periodontal pathogens fluctuated in low levels even 12 months after treatment and could be maintained at low level by supportive periodontal care at 3-month intervals.

title: Subgingival microflora and treatment in XXXX associated with @entity11 .

answer: @entity13


abstract: @entity13 affects both primary and permanent dentition. The purpose of this study was to examine the composition of subgingival microflora of the permanent dentition in an 11-year-old Caucasian female, who had premature exfoliation of her deciduous teeth on her 5th year of age, and the response of this condition to the antibiotic therapy and supportive periodontal care. Gingival tissues were highly inflamed and @entity3 was detected radiographically. The @entity0 had experienced frequent @entity5 , @entity12 and recurrent @entity6 . Her mother had history of early onset @entity7 associated with @entity11 . Blood chemistry tests and immunological examinations were also performed. @entity2 samples were collected from the proximal sites of permanent molars, incisors, @entity1 and maxillary premolars. 27 different microbial species were isolated from the subgingival microflora. Among the predominant species were @entity8 (17.6%-7.3%), @entity9 (12.4%-4.7%), @entity15 sputigena (14.4%-10.4%), @entity15 (13.2%-6.9%) and @entity10 (9.3%-5.5%). Periodontal treatment consisted of scaling, root planing in conjunction with antibiotic administration of @entity14 312.5 mg and @entity4 200 mg, each t.i.d. for 10 days. 3 weeks after the antibiotic therapy, bacterial samples were collected from the same sites. All the periodontal pathogens were recovered in lower levels and A.actinomycetemcomitans was almost eliminated in the 3-week period. The evaluation of clinical indices at 3, 6 and 12 months showed that periodontal treatment in conjunction with antibiotics was effective and rapidly followed by marked clinical improvement. The microbiological monitoring at 3, 6 and 12 months after antibiotic treatment and each time prior to supportive periodontal care, revealed that the periodontal pathogens fluctuated in low levels even 12 months after treatment and could be maintained at low level by supportive periodontal care at 3-month intervals.

title: Subgingival microflora and treatment in @entity13 associated with XXXX .

answer: @entity11


abstract: OBJECTIVES: @entity0 satisfaction scores are increasing in importance. Although the influence of selected @entity0 and physician characteristics on satisfaction scores has been identified, the impact of different pediatric diagnoses is unknown. The purpose of this study was to compare @entity0 satisfaction scores in visits for @entity1 with visits for @entity3 or @entity2 . METHODS: A retrospective analysis of @entity0 satisfaction scores from pediatric visits for @entity1 , @entity3 , and @entity2 at three tertiary centers was performed. Satisfaction data were obtained from survey questions that used a 5-point scale ranging from very poor (1) to very good (5). Statistical analysis was performed using   (2) and Fisher exact tests. RESULTS: Data from 565 visits for @entity2 , 81 for @entity3 , and 57 for @entity1 were used. The mean scores in @entity1 visits for the likelihood of recommending the care provider, confidence in the care provider, and explanation by the care provider were 4.87, 4.79, and 4.70, respectively. These scores were not lower than visits for @entity2 and @entity3 (P < 0.05). The mean score for likelihood to recommend the practice after @entity1 visits was 4.73, with more scores of 3 or higher than @entity3 or @entity2 (P < 0.05). CONCLUSIONS: Satisfaction scores in pediatric @entity0 with @entity1 were not lower than visits for @entity2 or @entity3 . Future research can be directed toward identifying common goals in visits for pediatric @entity1 to further improve the @entity0 experience.

title: Influence of Back Pain on XXXX Satisfaction Scores.

answer: @entity0


abstract: OBJECTIVE: @entity1 ( @entity1 ) is a marker of tissue @entity4 in @entity6 @entity0 . It guides resuscitative measures, and predicts outcomes, complications and mortality. The aim of this study was to examine the presence of @entity1 in @entity0 with isolated severe @entity3 ( @entity3 ), and to assess if it correlates with the outcomes in these @entity0 . METHOD: This was a retrospective observational study. All @entity0 over the age of 16 years presenting to Aga Khan University Hospital from 2009 to 2013 with @entity3 , were included. Data was extracted from 2009 to 2013. Glasgow Outcome Scale (GOS) of 4 and 5 at last follow up was categorized as favorable outcome. Data was analyzed using SPSS version 19 and receiver operative curve (ROC) was generated for @entity1 as a predictor of mortality and unfavorable outcome. RESULTS: One hundred and eight @entity0 were analyzed. Ninety-eight (90.7%) were males. Mean age was 36.69      17.65. Eighty-eight (81.5%) @entity0 had @entity1 , while 20 (18.5%) @entity0 had base excess. 62 (58.5%) of the @entity0 had unfavorable outcomes. @entity1 on admission had a statistically significant negative correlation with Glasgow @entity5 Scale (GCS) on presentation (r  =  -0.239, p  =  0.025) and Revised @entity2 Score (RTS) (r  =  -0.214, p  =  0.046). However, there was no statistically significant difference in means of @entity1 between survivors and non survivors. Area under receiver operator curve (ROC) for @entity1 as a predictor of mortality statistically non-significant. CONCLUSION: Although @entity1 is correlated with GCS at presentation and RTS, it is not a reliable prognostic marker for outcome and mortality in @entity0 with @entity3 .

title: Does base deficit predict mortality in @entity0 with severe XXXX ?

answer: @entity3


abstract: OBJECTIVE: @entity1 ( @entity1 ) is a marker of tissue @entity4 in @entity6 @entity0 . It guides resuscitative measures, and predicts outcomes, complications and mortality. The aim of this study was to examine the presence of @entity1 in @entity0 with isolated severe @entity3 ( @entity3 ), and to assess if it correlates with the outcomes in these @entity0 . METHOD: This was a retrospective observational study. All @entity0 over the age of 16 years presenting to Aga Khan University Hospital from 2009 to 2013 with @entity3 , were included. Data was extracted from 2009 to 2013. Glasgow Outcome Scale (GOS) of 4 and 5 at last follow up was categorized as favorable outcome. Data was analyzed using SPSS version 19 and receiver operative curve (ROC) was generated for @entity1 as a predictor of mortality and unfavorable outcome. RESULTS: One hundred and eight @entity0 were analyzed. Ninety-eight (90.7%) were males. Mean age was 36.69      17.65. Eighty-eight (81.5%) @entity0 had @entity1 , while 20 (18.5%) @entity0 had base excess. 62 (58.5%) of the @entity0 had unfavorable outcomes. @entity1 on admission had a statistically significant negative correlation with Glasgow @entity5 Scale (GCS) on presentation (r  =  -0.239, p  =  0.025) and Revised @entity2 Score (RTS) (r  =  -0.214, p  =  0.046). However, there was no statistically significant difference in means of @entity1 between survivors and non survivors. Area under receiver operator curve (ROC) for @entity1 as a predictor of mortality statistically non-significant. CONCLUSION: Although @entity1 is correlated with GCS at presentation and RTS, it is not a reliable prognostic marker for outcome and mortality in @entity0 with @entity3 .

title: Does base deficit predict mortality in XXXX with severe @entity3 ?

answer: @entity0


abstract: BACKGROUND: In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose @entity8 decreased postoperative @entity3 requirement and @entity3 -related adverse effects as @entity2 after @entity4 surgery. METHODS: After IRB approval and informed consent, 36 @entity0 , aged 10-19  years, undergoing posterior correction surgery for adolescent @entity7 , were randomly allocated into two groups: intra- and postoperative @entity8 infusion at a rate of 2   g/kg/min until 48  h after surgery ( @entity8 group, n  =  17) or infusion of an equal volume of saline (placebo group, n  =  19). All @entity0 were administered total intravenous anesthesia with @entity5 and @entity6 during surgery and intravenous @entity3 using a @entity0 -controlled analgesia device after surgery. The primary outcome was cumulative @entity3 consumption in the initial 48  h after surgery. @entity1 scores (Numerical Rating Scale, @entity9 , 0-10), sedation scales, incidence of @entity2 ( @entity2 ), and antiemetic consumption were recorded by nurses blinded to the study protocol for 48  h after surgery. RESULTS: @entity0 characteristics did not differ between the two groups. Cumulative @entity3 consumption for 48  h after surgery was significantly lower in the @entity8 group compared to the placebo group (0.89      0.08  mg/kg vs. 1.16      0.07  mg/kg, 95% confidence interval for difference between the means, 0.03-0.48  mg/kg, P  =  0.019). @entity9 @entity1 , sedation scales, and incidence of @entity2 did not differ between the two groups. Antiemetic consumption was significantly smaller in @entity8 group. CONCLUSIONS: Intra- and postoperative infusion of low-dose @entity8 reduced cumulative @entity3 consumption and antiemetic requirement for 48  h after surgery.

title: Intra- and postoperative low-dose XXXX for adolescent @entity7 surgery: a randomized controlled trial.

answer: @entity8


abstract: BACKGROUND: In this randomized controlled trial, we examined whether intra- and postoperative infusion of low-dose @entity8 decreased postoperative @entity3 requirement and @entity3 -related adverse effects as @entity2 after @entity4 surgery. METHODS: After IRB approval and informed consent, 36 @entity0 , aged 10-19  years, undergoing posterior correction surgery for adolescent @entity7 , were randomly allocated into two groups: intra- and postoperative @entity8 infusion at a rate of 2   g/kg/min until 48  h after surgery ( @entity8 group, n  =  17) or infusion of an equal volume of saline (placebo group, n  =  19). All @entity0 were administered total intravenous anesthesia with @entity5 and @entity6 during surgery and intravenous @entity3 using a @entity0 -controlled analgesia device after surgery. The primary outcome was cumulative @entity3 consumption in the initial 48  h after surgery. @entity1 scores (Numerical Rating Scale, @entity9 , 0-10), sedation scales, incidence of @entity2 ( @entity2 ), and antiemetic consumption were recorded by nurses blinded to the study protocol for 48  h after surgery. RESULTS: @entity0 characteristics did not differ between the two groups. Cumulative @entity3 consumption for 48  h after surgery was significantly lower in the @entity8 group compared to the placebo group (0.89      0.08  mg/kg vs. 1.16      0.07  mg/kg, 95% confidence interval for difference between the means, 0.03-0.48  mg/kg, P  =  0.019). @entity9 @entity1 , sedation scales, and incidence of @entity2 did not differ between the two groups. Antiemetic consumption was significantly smaller in @entity8 group. CONCLUSIONS: Intra- and postoperative infusion of low-dose @entity8 reduced cumulative @entity3 consumption and antiemetic requirement for 48  h after surgery.

title: Intra- and postoperative low-dose @entity8 for adolescent XXXX surgery: a randomized controlled trial.

answer: @entity7


abstract: 1. The contribution of reactive @entity5 species to the development of airway hyperresponsiveness in a @entity0 model of @entity1 was investigated by the use of selective inhibitors of @entity3 and @entity2 formation. 2. Sensitized @entity0 , repeatedly challenged with @entity7 showed a significant (P<0.001, n=9) increase in airway responsiveness measured using whole body plethysmography. This hyperresponsiveness was accompanied by an influx of eosinophils into the airway lumen and increased levels of @entity7 -specific serum IgE. 3. Treatment of @entity0 with the iNOS inhibitor 1400 W or the @entity4 -oxidase inhibitor @entity8 did not significantly alter cellular influx into the airway lumen nor serum @entity7 specific IgE. In contrast, @entity8 as well as 1400 W inhibited @entity7 -induced airway hyperresponsiveness (P<0.001 and P<0.05 respectively, n=9). Furthermore, the airways of allergen challenged animals showed clear @entity6 staining, which was mainly located in eosinophils. Remarkably, treatment with @entity8 or 1400 W did not alter @entity6 staining. 4. These data suggest that the development of airway hyperresponsiveness during the airway inflammation upon @entity7 challenge is dependent on the release of both @entity2 and @entity3 and is therefore likely to be dependent on reactive @entity5 species. This mechanism, however, is not reflected by @entity6 formation in the airways.

title: XXXX and 1400 W prevents airway hyperresponsiveness during allergic reactions in @entity0 .

answer: @entity8


abstract: 1. The contribution of reactive @entity5 species to the development of airway hyperresponsiveness in a @entity0 model of @entity1 was investigated by the use of selective inhibitors of @entity3 and @entity2 formation. 2. Sensitized @entity0 , repeatedly challenged with @entity7 showed a significant (P<0.001, n=9) increase in airway responsiveness measured using whole body plethysmography. This hyperresponsiveness was accompanied by an influx of eosinophils into the airway lumen and increased levels of @entity7 -specific serum IgE. 3. Treatment of @entity0 with the iNOS inhibitor 1400 W or the @entity4 -oxidase inhibitor @entity8 did not significantly alter cellular influx into the airway lumen nor serum @entity7 specific IgE. In contrast, @entity8 as well as 1400 W inhibited @entity7 -induced airway hyperresponsiveness (P<0.001 and P<0.05 respectively, n=9). Furthermore, the airways of allergen challenged animals showed clear @entity6 staining, which was mainly located in eosinophils. Remarkably, treatment with @entity8 or 1400 W did not alter @entity6 staining. 4. These data suggest that the development of airway hyperresponsiveness during the airway inflammation upon @entity7 challenge is dependent on the release of both @entity2 and @entity3 and is therefore likely to be dependent on reactive @entity5 species. This mechanism, however, is not reflected by @entity6 formation in the airways.

title: @entity8 and 1400 W prevents airway hyperresponsiveness during allergic reactions in XXXX .

answer: @entity0


abstract: The @entity0 mutants amnesiac, @entity4 ( @entity4 ), and rutabaga were isolated after associative conditioning tests, during which animals were trained to associate the presence of an odor with that of @entity2 ( @entity2 ). In the absence of conditioning, the odor avoidance (OA) of these mutants was shown to be normal, indicating that their poor associative conditioning performance was attributable to specific @entity3 . However, I show that the OA of the mutants is greatly decreased after their exposure to @entity2 . This effect can last for hours. These results strongly suggest that part of the defect displayed by these mutants in associative conditioning tests does not correspond to a @entity3 but might arise from abnormal sensitivity to stressful stimuli. I looked at the OA after @entity2 of two previously characterized @entity4 mutants. Df(1)N79f specifically decreases @entity4 expression in the mushroom bodies, leading to a normal level of learning but decreased memory. Df(1)N79f mutants displayed a normal OA after @entity2 . Df(1)N64j15 affects the entire brain expression of @entity4 , leading to decreased learning and memory. Df(1)N64j15 animals showed a strong decrease of their OA after @entity2 . Thus, the lack of @entity4 "general" expression is most likely responsible for the @entity1 , which would be responsible for the apparent @entity3 after conditioning. In contrast, the @entity4 phosphodiesterase accumulated in the mushroom bodies would be involved specifically in memory formation.

title: Decreased odor avoidance after electric shock in XXXX mutants biases learning and memory tests.

answer: @entity0


abstract: CONTEXT: Measurement of @entity2 (Tg) by mass spectrometry (Tg-MS) is emerging as a tool for accurate Tg quantification in patients with anti-Tg autoantibodies (TgAbs). OBJECTIVE: The objective of the study was to perform analytical and clinical evaluations of two Tg-MS assays in comparison with immunometric Tg assays (Tg-IAs) and Tg RIAs (Tg-RIAs) in a cohort of @entity1 @entity0 . METHODS: A total of 589 samples from 495 @entity0 , 243 TgAb-/252 TgAb+, were tested by Beckman, Roche, Siemens-Immulite, and Thermo-Brahms Tg and TgAb assays, two Tg-RIAs, and two Tg-MS assays. RESULTS: The frequency of TgAb+ was 58%, 41%, 27%, and 39% for Roche, Beckman, Siemens-Immulite, and Thermo-Brahms, respectively. In TgAb- samples, clinical sensitivities and specificities of 100% and 74%-100%, respectively, were observed across all assays. In TgAb+ samples, all Tg-IAs demonstrated assay-dependent Tg underestimation, ranging from 41% to 86%. In TgAb+ samples, the use of a common cutoff (0.5 ng/mL) for the Tg-MS, three Tg-IAs, and the USC-RIA improved the sensitivity for the Tg-MSs and Tg-RIAs when compared with the Tg-IAs. In up to 20% of TgAb+ cases, Tg-IAs failed to detect Tg that was detectable by Tg-MS. In Tg-RIAs false-high biases were observed in TgAb+ samples containing low Tg concentrations. CONCLUSIONS: Tg-IAs remain the method of choice for Tg quantitation in TgAb- @entity0 . In TgAb+ @entity0 with undetectable Tg by immunometric assay, the Tg-MS will detect Tg in up to 20% additional cases. The Tg-RIA will detect Tg in approximately 35% cases, but a significant proportion of these will be clinical false-positive results. The undetectable Tg-MS seen in approximately 40% of TgAb+ cases in @entity0 with disease need further evaluation.

title: XXXX (Tg) Testing Revisited: Tg Assays, TgAb Assays, and Correlation of Results With Clinical Outcomes.

answer: @entity2


abstract: CONTEXT: Tarragon (Artemisia dracunculus L., Asteraceae) is an ancient herb, which is widely used as a medicine, flavoring, or fragrance. OBJECTIVE: To determine the antinociceptive and anti-inflammatory effects of aerial parts of tarragon, we investigated the effects of ethanolic extract of the plant in adult male Balb/c @entity1 . MATERIALS AND METHODS: Antinociceptive activity was determined using @entity4 , hot-plate, and writhing tests. The effect of the ethanolic extract on acute @entity2 was evaluated by @entity8 -induced ear @entity0 in @entity1 . The ethanolic extract was administered at doses of 5, 10, 50, and 100   mg/kg, i.p. The control group received saline as vehicle of ethanolic extract. RESULTS: Our results showed that the ethanolic extract (50 and 100   mg/kg) decreased both phases of @entity3 in the @entity4 test (ED50   =   109.66 and 87.13   mg/kg, respectively). In the hot-plate test, the extract (50 and 100   mg/kg) increased @entity3 threshold during 60   min (ED50   =   81.03   mg/kg). The extract (50 and 100   mg/kg) exhibited antinociceptive activity against @entity7 -induced writhing (ED50   =   66.99   mg/kg). The extract (50 and 100   mg/kg) showed significant activity in the xylene ear @entity0 test (ED50   =   78.20   mg/kg). Pretreatment of the animals with @entity6 decreased the @entity5 induced by the extract in hot-plate and @entity4 tests; therefore, opioid receptors may be involved, at least partly, in the analgesic effect of tarragon extract. DISCUSSION AND CONCLUSION: The results suggested that tarragon have significant analgesic and anti-inflammatory effects in @entity1 , and, therefore, further studies are required to evaluate these effects and additional potential of the plant.

title: Antinociceptive and anti-inflammatory effects of the aerial parts of Artemisia dracunculus in XXXX .

answer: @entity1


abstract: UNASSIGNED: Phytoremediation is an emerging technology that uses green plants (living machines) for removal of contaminants of concern (COC). These plant species have the potential to remove the COC, thereby restoring the original condition of soil or water environment. The present study focuses on assessing the heavy metals (COC) present in the contaminated water bodies of Ranchi city, Jharkhand, India. Phytoremedial potential of three plant species: @entity2 , Eichornia crassipes and Monochoria hastata were assessed in the present study. Heterogenous accumulation of metals was found in the three plant species. It was observed that the ratio of heavy metal concentration was different in different parts, i.e., shoots and roots. Positive results were also obtained for translocation factor of all species with minimum of 0.10 and maximum of 1. It was found experimentally that M. hastata has the maximum BFC for root as 4.32 and shoot as 2.70 (for @entity1 ). For @entity2 , BCF of maximum was observed for root (163.5) and respective shoot 86.46 (for @entity0 ), followed by 7.3 and 5.8 for root and shoot (for @entity1 ) respectively. E. crassipes was found to possess a maximum BCF of 278.6 (for @entity1 and 151 (for @entity0 ) and shoot as 142 (for @entity1 ) and 36.13 (for @entity0 ).

title: Phytoremedial Potential of XXXX , Eichornia crassipes and Monochoria hastata found in Contaminated Water Bodies Across Ranchi City (India).

answer: @entity2


abstract: Serological methods have been used for detecting infection with @entity4 . We have applied a serological test to explore the possibility it could detect a bacterial relapse among @entity0 who have been cured with chemotherapy. More specifically we used an indirect enzyme-linked immunosorbant assay (ELISA) using the natural disaccharide (ND) of the phenolic glycolipid antigen of @entity4 linked to bovine serum albumin as antigen. Antibody levels were measured in sera from normal controls, active @entity2 cases, cured @entity2 @entity0 , and relapsing @entity2 @entity0 . We correlated antibody levels with the type of @entity2 , the bacterial index, and with relapse among @entity2 @entity0 . In our hands, the ND-ELISA, when applied to screening for infection with @entity4 , had excellent sensitivity, specificity, positive and negative predictive values, and both a low false positive rate and a low false negative rate. Antibody levels gradually increased among active @entity0 from the tuberculoid to the lepromatous end of the @entity2 spectrum. There was a year-by-year fall in antibody levels in @entity0 responding to chemotherapy. Antibody levels and the bacterial index were correlated using the Spearman's rank correlation method. Serial antibody levels were measured in 666 @entity2 @entity0 after being cured with @entity3 monotherapy. Over a three year follow up, 95 multibacillary patients became antibody positive and 12 of them had bacterial relapses of their disease. In contrast, among 335 cases that remained antibody negative, only one relapse was seen. Among 44 paucibacillary cured @entity0 who became antibody positive, there was one relapse. There were 192 such @entity0 who remained antibody negative and one relapsed. The risk of relapse is 6.7 times higher among cured multibacillary @entity0 compared to cured paucibacillary @entity0 . Overall, the cumulative relapse rate among antibody positive cases was 13.7%, compared to 0.4% among antibody negative @entity0 . We conclude that the ND-ELISA is a useful tool both for screening for @entity1 with @entity4 and for predicting a relapse in cured @entity0 , particularly in cured multibacillary @entity0 .

title: A study on a possibility of predicting early relapse in XXXX using a ND-O-BSA based ELISA.

answer: @entity2


abstract: Obesity is characterized by hemodynamic and metabolic alterations. Autonomic control on cardiac function involvement is controversial. The aim of the study was to assess early sign of cardiac @entity4 in @entity1 , using time- and frequency-domain heart rate variability (HRV) analysis in a pediatric population. METHODS: 32 @entity1 @entity0 (OB) (17 M, 15 F; 13.9 +/- 1.7 y) were compared with 13 healthy lean subjects (7 M, 6 F; 12.9 +/- 1.6 y). For each @entity0 , the authors performed a clinical examination, laboratory testing, blood pressure (BP) measurements, and 24-hour electrocardiograph/ambulatory BP monitoring. The spectral power was quantified in total power, low-frequency (LF) power, index of sympathetic tone, high-frequency (HF) power, index of vagal tone, and LF/HF ratio. Low frequency and HF were averaged to obtain 3 measures: 24-hour, daytime, and nighttime levels. Total, long-term, and short-term time-domain HRV values were calculated. RESULTS: The @entity1 @entity0 had higher casual and ambulatory BP, and higher fasting @entity3 , insulin, and @entity2 levels. Overall HRV values were not significantly lower in OB. The @entity1 @entity0 had significantly lower 24-hour and nighttime high-frequency normalized units, and time-domain measures of vagal activity. Low-frequency power showed an inverse but not significant pattern. The OB group had significantly greater 24-hour and nighttime LF/HF ratios. CONCLUSIONS: The authors found an increase in heart rate and in BP associated with parasympathetic heart rate control decrease in stabilized @entity1 normotensive @entity0 .

title: Heart rate variability in childhood XXXX .

answer: @entity1


abstract: BACKGROUND: Survival was prolonged in selected @entity0 with sustained @entity3 who received @entity2 ( @entity2 ) in the @entity5 ( @entity5 ) study. The Midlands trial of empirical @entity6 versus electrophysiologically guided intervention and cardioverter implant in @entity3 (MAVERIC) registry is a population based trial. OBJECTIVE: To determine the number of @entity0 who satisfy the @entity5 criteria because of the high cost of @entity2 . DESIGN: Observational study, based on a continuing trial. SETTING: All coronary care units in the Midlands region in the United Kingdom (population 9.1 million). @entity0 : @entity0 presenting to a coronary care unit with sustained @entity3 not related to an acute @entity1 are entered onto the registry. Those who consent to the MAVERIC study are randomised to receive either empirical @entity6 or electrophysiologically guided treatment. Demographic data, details of clinical presentation, and echocardiographic findings are collected. These data have been used to calculate the number of @entity0 who satisfy the @entity5 criteria and would benefit from @entity4 implantation. The financial implications have been calculated for the region and nationally. RESULTS: 132 @entity0 were entered onto the registry during the first five months of the MAVERIC study; 69 @entity0 fulfilled the @entity5 criteria. Extrapolation of these data over a 12 month period suggests implantation of at least 166 new @entity2 (compared with 23 implants in 1996). This would increase the UK @entity4 implant rate from five to at least 18 per million of the population, costing the National Health Service 24.1 Pounds million per annum. CONCLUSION: Application of the @entity5 criteria in the UK will cause a great increase in the @entity4 implant rate, with serious financial implications.

title: Potential impact of antiarrhythmic drugs versus implantable defibrillators on the management of @entity3 : the Midlands trial of empirical XXXX versus electrophysiologically guided intervention and cardioverter implant registry data.

answer: @entity6


abstract: BACKGROUND: Survival was prolonged in selected @entity0 with sustained @entity3 who received @entity2 ( @entity2 ) in the @entity5 ( @entity5 ) study. The Midlands trial of empirical @entity6 versus electrophysiologically guided intervention and cardioverter implant in @entity3 (MAVERIC) registry is a population based trial. OBJECTIVE: To determine the number of @entity0 who satisfy the @entity5 criteria because of the high cost of @entity2 . DESIGN: Observational study, based on a continuing trial. SETTING: All coronary care units in the Midlands region in the United Kingdom (population 9.1 million). @entity0 : @entity0 presenting to a coronary care unit with sustained @entity3 not related to an acute @entity1 are entered onto the registry. Those who consent to the MAVERIC study are randomised to receive either empirical @entity6 or electrophysiologically guided treatment. Demographic data, details of clinical presentation, and echocardiographic findings are collected. These data have been used to calculate the number of @entity0 who satisfy the @entity5 criteria and would benefit from @entity4 implantation. The financial implications have been calculated for the region and nationally. RESULTS: 132 @entity0 were entered onto the registry during the first five months of the MAVERIC study; 69 @entity0 fulfilled the @entity5 criteria. Extrapolation of these data over a 12 month period suggests implantation of at least 166 new @entity2 (compared with 23 implants in 1996). This would increase the UK @entity4 implant rate from five to at least 18 per million of the population, costing the National Health Service 24.1 Pounds million per annum. CONCLUSION: Application of the @entity5 criteria in the UK will cause a great increase in the @entity4 implant rate, with serious financial implications.

title: Potential impact of antiarrhythmic drugs versus implantable defibrillators on the management of XXXX : the Midlands trial of empirical @entity6 versus electrophysiologically guided intervention and cardioverter implant registry data.

answer: @entity3


abstract: The development of the @entity0 inner ear involves a complex series of cell-cell and cell-extracellular matrix interactions. These interactions are likely to be mediated by families of adhesion molecules, including the integrins. We have studied the expression of three integrin subunits known to be expressed on epithelia in a number of tissues (namely, @entity4 , @entity5 , and @entity3 ) during the development of the @entity1 inner ear. At E10.5, both @entity6 were expressed in the epithelial layers of the otocyst. The expression of @entity5 was concentrated in an anterioventral region of the epithelium and in a proportion of the cells forming the cochlear-vestibular and @entity2 . By E12.5, @entity5 showed a more restricted expression, confined mainly to the pro-sensory epithelia and the neural processes from the cochlear-vestibular ganglion. In contrast, @entity4 was expressed in epithelia adjacent to the pro-sensory areas. This reciprocal expression pattern was maintained until birth. Between birth and P6, a switch in expression occurred such that @entity4 was upregulated and @entity5 was downregulated in the sensory epithelia of both the auditory and vestibular systems. At this stage, @entity4 was expressed in all the epithelia lining the scala media, thus defining the endolymph compartment. The expression of @entity3 was restricted to epithelial/mesenchymal borders throughout the developmental stages studied, suggesting that @entity5 expression observed within the epithelium and neuronal tissue was alpha6beta1. The early expression and changing pattern of @entity4 and @entity5 integrins during development of the @entity0 inner ear suggests that they may be involved in the molecular processes that define epithelial boundaries and guide sensory innervation.

title: Differential expression of XXXX integrins in the developing @entity1 inner ear.

answer: @entity6