abstract: @entity4 is prevalent in @entity0 following @entity3 , which can have a significant impact on the quality of life of the @entity0 with @entity3 . One of the new methods for treatment of @entity0 with @entity4 is @entity1 ( @entity1 ). The aim of this study was to investigate the efficacy of @entity2 in individuals with chronic @entity4 . This study had a prospective, single-subject study with A-B-A design. The @entity1 was administered to two @entity0 with chronic @entity4 . @entity0 were a 57-year-old male and a 45-year-old female and had a @entity3 60 and 36 months ago, respectively. In this study, the naming test was used as the outcome measure. The naming test was administered in three baseline sessions with 1 week interval between tests (phase A). @entity0 received @entity1 for four consecutive weeks (3 days/week). Four measurements were taken during the treatment phase (phase B). In follow-up phase (phase A) two other measurements were performed. Visual analysis consisting of level, regression line, and variability were used to determine the effects of @entity1 on naming. Both @entity0 increased scores on naming test after phase A and B. The mean of the naming score improved from the baseline to the intervention phase in both @entity0 . There was a positive trend in naming scores during the treatment phase compared with the trend in the baseline demonstrated by both @entity0 . The results of this study showed that the @entity1 can be effective in improving the naming deficit in @entity0 with chronic post- @entity3 @entity4 .

title: A Single-subject Study to Examine the Effects of Constrained-induced XXXX Therapy on Naming Deficit.

answer: @entity4


abstract: BACKGROUND: Activating mutations in the @entity7 ( @entity7 ) cause autosomal dominant @entity1 ( @entity1 ). @entity7 expression is upregulated in renal biopsies of @entity0 with @entity6 ( @entity6 ) and animal models thereof. In @entity6 , disease progression is characterized by @entity4 . In addition, a context-dependent @entity7 overexpression was recently suggested in complement-mediated podocyte injury in e.g. @entity6 . Hence, we hypothesized that genetic variants in @entity7 might affect susceptibility to development or progression of @entity6 . METHODS _ RESULTS: Genomic DNA was isolated from blood samples of 101 @entity6 @entity0 and 292 controls. By direct sequencing of the entire @entity7 gene, 13 single nucleotide polymorphisms (SNPs) were identified in the @entity6 cohort, two of which were causing an @entity3 substitution ( @entity8 ; @entity9 and @entity10 , @entity11 ). No statistically significant differences in genotypes or allele frequencies between @entity0 and controls were observed. Clinical outcome in @entity0 was determined (remission n=26, @entity2 n=46, persistent @entity5 n=29, follow-up median 80 months {range 51-166}). The 13 identified SNPs showed no association with remission or @entity2 . There were no differences in genotypes or allele frequencies between @entity0 in remission and progressors. CONCLUSIONS: Our data suggest that @entity7 polymorphisms do not affect susceptibility to @entity6 , or clinical outcome in @entity6 .

title: @entity7 single nucleotide polymorphisms and progression of XXXX .

answer: @entity1


abstract: BACKGROUND: Activating mutations in the @entity7 ( @entity7 ) cause autosomal dominant @entity1 ( @entity1 ). @entity7 expression is upregulated in renal biopsies of @entity0 with @entity6 ( @entity6 ) and animal models thereof. In @entity6 , disease progression is characterized by @entity4 . In addition, a context-dependent @entity7 overexpression was recently suggested in complement-mediated podocyte injury in e.g. @entity6 . Hence, we hypothesized that genetic variants in @entity7 might affect susceptibility to development or progression of @entity6 . METHODS _ RESULTS: Genomic DNA was isolated from blood samples of 101 @entity6 @entity0 and 292 controls. By direct sequencing of the entire @entity7 gene, 13 single nucleotide polymorphisms (SNPs) were identified in the @entity6 cohort, two of which were causing an @entity3 substitution ( @entity8 ; @entity9 and @entity10 , @entity11 ). No statistically significant differences in genotypes or allele frequencies between @entity0 and controls were observed. Clinical outcome in @entity0 was determined (remission n=26, @entity2 n=46, persistent @entity5 n=29, follow-up median 80 months {range 51-166}). The 13 identified SNPs showed no association with remission or @entity2 . There were no differences in genotypes or allele frequencies between @entity0 in remission and progressors. CONCLUSIONS: Our data suggest that @entity7 polymorphisms do not affect susceptibility to @entity6 , or clinical outcome in @entity6 .

title: XXXX single nucleotide polymorphisms and progression of @entity1 .

answer: @entity7


abstract: OBJECTIVES: To investigate changes in urinary nerve growth factor (uNGF) in @entity0 with symptomatic detrusor overactivity (DO) following @entity2 ( @entity2 ) for sacral neuromodulation vs controls. STUDY DESIGN: There were 23 subjects with @entity3 and DO who failed management with anticholinergics and 22 controls consented to participate in this prospective pilot study. Urine specimens were collected from controls at baseline for evaluation of uNGF and @entity1 . Subjects were evaluated at baseline and 5 days after a trial of sacral nerve stimulation referred to as a @entity2 . Each visit included urine collection for uNGF and, Incontinence Quality of Life Questionnaire, Urinary Distress Inventory Questionnaire, postvoid residual volume, and a 3-day voiding diary. uNGF levels were measured by enzyme-linked immunosorbent assay and expressed as uNGF pg/ @entity1 mg. RESULTS: Subjects with DO had significantly higher baseline uNGF  levels (corrected for @entity1 ) compared with controls (19.82 pg/mg vs 7.88 pg/mg, P < .002). Seventeen DO subjects underwent @entity2 and were evaluated at the end of the testing period. There was a significant improvement in quality of life scores for subjects after @entity2 compared with baseline (Urinary Distress Inventory Questionnaire: 7.0 vs 13.7, P < .001; Incontinence Quality of Life Questionnaire: 87.3 vs 52.8, P < .0001). Concordantly, uNGF levels significantly decreased from 17.23 pg/mg to 9.24 pg/mg (P < .02) after @entity2 . CONCLUSION: uNGF levels decrease with symptomatic response in DO subjects undergoing @entity2 . DO subjects had significantly higher uNGF at baseline vs controls, and uNGF levels significantly decreased after only 5 days of sacral nerve stimulation. These findings support a larger study to validate the use of uNGF as an objective tool to assess therapeutic outcome in @entity0 undergoing @entity2 for sacral neuromodulation.

title: Sacral nerve stimulation reduces elevated urinary nerve growth factor levels in XXXX with symptomatic detrusor overactivity.

answer: @entity0


abstract: OBJECTIVES: To characterize pathological and @entity1 -specific outcomes of surgically resected @entity3 and to identify clinical or radiographic features associated with these outcomes. METHODS AND MATERIALS: All @entity0 at our institution who underwent radical or partial nephrectomy for complex renal cystic masses between 2004 and 2011 with available computed tomographic imaging were included. The Bosniak score was determined, as were 10 specific radiographic characteristics of @entity2 in @entity0 with preoperative imaging available for review. These characteristics were correlated with @entity6 histopathology. Recurrence-free survival after surgery was determined. RESULTS: Overall, 133 @entity0 underwent renal surgery for complex cystic lesions, 89 (67%) of whom had malignant lesions. Malignancy risk increased with Bosniak score (P <=0.01) and presence of mural nodules (P = 0.01). Most (63%) @entity1 demonstrated clear cell histology. The @entity4 (25%) exhibited lower enhancement levels (P = 0.04) and were less often septated (P<0.01). Of the @entity1 , 79% were low stage ( @entity5 ), and 73% were Fuhrman grade 1 or 2. Large cyst size was associated with advanced @entity1 stage (P = 0.05). Neither Bosniak score nor any other radiographic parameter was associated with Fuhrman grade. In 70 @entity0 with a median follow-up of 43 months, only 1 (1.4%) developed disease recurrence. CONCLUSIONS: Most @entity2 are low-stage, low-grade lesions. @entity4 account for nearly a quarter of @entity2 and have unique radiographic characteristics. Disease recurrence after surgical resection is rare. These findings suggest an indolent behavior for @entity3 , and these lesions may be amenable to active surveillance.

title: Pathological characteristics and radiographic correlates of XXXX .

answer: @entity2


abstract: AIMS: Incidence of primary @entity8 (PCTs) is not known. Literature data derive from autoptic studies or echocardiographic registries. An incidence of 1 of 1000 autoptic and 1.5 of 1000 echocardiographic study is reported but data from a general population are not available. The aim of our study was to evaluate the incidence rate of PCTs in the general population. METHODS: All @entity0 with suspected cardiac mass were evaluated with basal echocardiogram and/or transesophageal echocardiogram/cardiac magnetic resonance by Grosseto's cardiology department, the county referral center for both adult and pediatric populations. Diagnosis was confirmed at surgical excision (32), autoptic specimens (3) or by multimodal imaging when surgery was not indicated (7). The database of the county health system was interrogated to identify residents with The International Classification of Diseases-9 codes of @entity10 . Forty-two consecutive cases of PCTs were diagnosed from 1 January 1998, through 31 December 2011, among residents in Grosseto's county. RESULTS: Incidence rate of PCTs was 1.38 of 100000 inhabitants per year. PCTs were benign in 38 @entity0 (90.5%) and malignant in four (9.5%). Twenty @entity7 were found (48%), followed by seven fibroelastomas (15%), six @entity2 (15%), three @entity9 (8%), two @entity5 (5%), two @entity1 (5%), one @entity4 (2%) and one @entity6 (2%). Incidence of benign @entity10 was 1.24 of 100000/year; referring only to @entity7 we found an incidence of 0.68 of 100000/year. CONCLUSION: This is the first population study on @entity10 , a @entity3 with an incidence rate of 1.38 new cases per 100,000 residents per year.

title: Incidence rate of primary XXXX : a 14-year population study.

answer: @entity8


abstract: OBJECTIVE: Through clinical observation of @entity3 after CO    laser cordectomy under suspensive laryngoscope to discuss the effects of laryngopharyngeal reflux(LPR) to @entity2 . METHODS: According to the classification of depth and range of CO    laser cordectomy, 111 cases were divided into 5 groups, and the incidence of postoperative @entity3 of each group was observed. The largest number of the 5 groups was 49 cases of type III CO    laser cordectomy which was subdivided into 4 groups according to whether or not laryngopharyngeal reflux and whether or not proton pump inhibitor (PPI) treatment. RESULTS: In 111 cases, 56 cases (50.5%) developed @entity3 after CO    laser cordectomy. The incidence of @entity2 after surgery was 10% (1/10), 26.1% (6/23), 53.1% (26/49), 78.6% (11/14), 80.0% (12/15) in I, II, III, IV, V type, respectively. It had statistical significance in chi-square test between 5 kinds of operative classification and the incidences of postoperative @entity3 (     = 20.32, P < 0.01) and Spearman correlation analysis showed positive correlation between classification of operation and incidences of @entity3 (r = 0.44, P < 0.01). According to LPR (-), LPR (+)and PPI (+), PPI (-), the incidence of @entity3 had statistical significance in these 4 group @entity0 of 49 type III cases (    = 5.83, P < 0.05). The incidence of @entity3 after surgery was the lowest in LPR (-) PPI (+) group (30%) and the highest in LPR (+) PPI (-) group (80%), and it showed significant difference (     = 6.25, P < 0.05). CONCLUSIONS: With the @entity1 and the range after CO    laser cordectomy, it appears rising trend in incidence of @entity3 . @entity4 and PPI therapy on the incidence of @entity2 has certain influence.

title: [Clinical observation of XXXX after CO    laser cordectomy and laryngopharyngeal reflux].

answer: @entity2


abstract: INTRODUCTION: The purpose of the current study was to investigate the effects of residual articular @entity3 after Bennett's @entity1 on load distribution of the joint surface. Our aim was to investigate whether a residual joint step and the altered load distribution led to negative clinical outcomes or symptomatic @entity2 of the trapeziometacarpal joint. @entity0 AND METHODS: Twenty-four @entity0 were available for long-term follow-up examination and were contacted by phone, and they returned for follow-up examination. Computed tomography (CT) scans of both carpometacarpal (CMC) joints were performed. CT scans were taken in the sagittal plane of the forearms with a slice thickness of 0.625 mm for three-dimensional reconstruction. The CMC joints were analysed due to a residual step in the joint. Only @entity0 with a residual step-off were included in this study. To determine the areas of maximum density in the joint, CT-osteoabsorptiometry was performed. RESULTS: Ten @entity0 had the maximum loading area radial and two @entity0 central. The second major position of mineralization was detected central in four @entity0 , volar-ulnar in two @entity0 , radial in one @entity0 , dorso-radial in one @entity0 , volar in one @entity0 and volar-radial in two @entity0 . CONCLUSION: Finally, no higher loading in the area of the beak fragment could be found. The Wagner technique, even if it results in a persistent 1-2-mm intra-articular step-off of the beak fragment, is still the favourable method for the treatment of @entity1 .

title: Pressure distribution in carpometacarpal joint, due to step-off in operatively treated XXXX .

answer: @entity1


abstract: UNASSIGNED: Constitutive activation of @entity5 pathway, that is activated by various stimuli including growth factors and oncogenic driver mutations, is observed in various @entity1 . However, the difference of the activated levels of the pathway is still unclear in clinical significances. The aim of this study was to investigate the effect of different @entity3 pathway activation, assessed by the expression levels of phosphorylated (p) @entity3 , on the prognosis of advanced @entity4 @entity0 . @entity2 -embedded lung biopsy samples were obtained from 85 @entity4 @entity0 . Correlation between pERK1/2 expression levels that were assessed by immunohistochemistry (IHC) analysis and oncogenic driver mutation status, clinicopathological factors, outcome from standard anticancer therapies, and prognosis was investigated. Varying levels of pERK1/2 expression were observed in 68 (80.0  %) @entity0 . The overall survival was significantly reduced in @entity0 with higher pERK1/2 expression in comparison to those with lower expression levels (P  =  0.03). In particular, higher pERK1/2 expression levels correlated with worse performance status and worse clinical outcome. Thus, the IHC analysis of pERK1/2 expression levels may predict @entity0 prognosis in advanced @entity4 . Inhibition of @entity3 pathway activated by various signals may improve the effects of standard chemotherapies and the clinical condition of @entity0 with @entity1 .

title: Increased phosphorylation of @entity3 is associated with worse chemotherapeutic outcome and a poor prognosis in advanced XXXX .

answer: @entity4


abstract: UNASSIGNED: Constitutive activation of @entity5 pathway, that is activated by various stimuli including growth factors and oncogenic driver mutations, is observed in various @entity1 . However, the difference of the activated levels of the pathway is still unclear in clinical significances. The aim of this study was to investigate the effect of different @entity3 pathway activation, assessed by the expression levels of phosphorylated (p) @entity3 , on the prognosis of advanced @entity4 @entity0 . @entity2 -embedded lung biopsy samples were obtained from 85 @entity4 @entity0 . Correlation between pERK1/2 expression levels that were assessed by immunohistochemistry (IHC) analysis and oncogenic driver mutation status, clinicopathological factors, outcome from standard anticancer therapies, and prognosis was investigated. Varying levels of pERK1/2 expression were observed in 68 (80.0  %) @entity0 . The overall survival was significantly reduced in @entity0 with higher pERK1/2 expression in comparison to those with lower expression levels (P  =  0.03). In particular, higher pERK1/2 expression levels correlated with worse performance status and worse clinical outcome. Thus, the IHC analysis of pERK1/2 expression levels may predict @entity0 prognosis in advanced @entity4 . Inhibition of @entity3 pathway activated by various signals may improve the effects of standard chemotherapies and the clinical condition of @entity0 with @entity1 .

title: Increased phosphorylation of XXXX is associated with worse chemotherapeutic outcome and a poor prognosis in advanced @entity4 .

answer: @entity3


abstract: OBJECTIVE: To investigate the clinicopathological characteristics, diagnostic criteria and differential diagnosis of @entity3 . METHODS: Twenty-five cases of @entity3 were analyzed for their clinical data, histomorphology and immumohisto chemical staining. Relevant literature was reviewed. RESULTS: The average age of the 25 @entity0 was 29 years. Fourteen @entity0 had full-term pregnancy, 10 had @entity4 , and 1 had @entity5 . Nineteen @entity0 had pregnancy complications. The @entity1 presented as red or dusty pink nodules with clear borders. The @entity1 size ranged from 1 to 16 cm. Microscopically, the @entity1 possessed abundant capillaries or cavernous blood spaces lined by hyperplastic endothelial cells. These cells were positive for @entity2 and Ki-67 index < 10%. CONCLUSIONS: @entity3 is a rare @entity1 , and is associated with various pregnancy complications. Misdiagnosis of cell-rich type @entity1 should be avoided.

title: [Clinicopathologic study of 25 cases of XXXX ].

answer: @entity3


abstract: UNASSIGNED: Relapse rates are high amongst @entity5 ( @entity5 ) suggesting that some alterations induced by @entity5 may remain after weight restoration. OBJECTIVE: To study the consequences of @entity5 without confounds of environmental variability, a rodent model of activity-based @entity3 (ABA) can be employed. We hypothesized that exposure to ABA during adolescence may have long-term consequences in taste function, cognition, and @entity2 -like behavior after weight restoration. METHODS: To test this hypothesis, we exposed adolescent female @entity1 to ABA (1.5 h food access, combined with @entity6 ) and compared their behavior to that of control @entity1 after weight restoration was achieved. The @entity1 were tested for learning/memory, @entity2 , food preference, and taste in a set of behavioral tests performed during the light period. RESULTS: Our data show that ABA exposure leads to reduced performance during the novel object recognition task, a test for contextual learning, without altering performance in the novel place recognition task or the Barnes maze, both tasks that test spatial learning. Furthermore, we do not observe alterations in unconditioned lick responses to @entity4 nor @entity7 (described by @entity0 as "sweet" and "bitter," respectively). Nor Do we find alterations in @entity2 -like behavior during an elevated plus maze or an open field test. Finally, preference for a diet high in fat is not altered. DISCUSSION: Overall, our data suggest that ABA exposure during adolescence impairs contextual learning in adulthood without altering spatial leaning, taste, @entity2 , or fat preference.    2015 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:169-181).

title: Exposure to activity-based @entity3 impairs contextual learning in weight-restored @entity1 without affecting spatial learning, taste, XXXX , or dietary-fat preference.

answer: @entity2


abstract: UNASSIGNED: Relapse rates are high amongst @entity5 ( @entity5 ) suggesting that some alterations induced by @entity5 may remain after weight restoration. OBJECTIVE: To study the consequences of @entity5 without confounds of environmental variability, a rodent model of activity-based @entity3 (ABA) can be employed. We hypothesized that exposure to ABA during adolescence may have long-term consequences in taste function, cognition, and @entity2 -like behavior after weight restoration. METHODS: To test this hypothesis, we exposed adolescent female @entity1 to ABA (1.5 h food access, combined with @entity6 ) and compared their behavior to that of control @entity1 after weight restoration was achieved. The @entity1 were tested for learning/memory, @entity2 , food preference, and taste in a set of behavioral tests performed during the light period. RESULTS: Our data show that ABA exposure leads to reduced performance during the novel object recognition task, a test for contextual learning, without altering performance in the novel place recognition task or the Barnes maze, both tasks that test spatial learning. Furthermore, we do not observe alterations in unconditioned lick responses to @entity4 nor @entity7 (described by @entity0 as "sweet" and "bitter," respectively). Nor Do we find alterations in @entity2 -like behavior during an elevated plus maze or an open field test. Finally, preference for a diet high in fat is not altered. DISCUSSION: Overall, our data suggest that ABA exposure during adolescence impairs contextual learning in adulthood without altering spatial leaning, taste, @entity2 , or fat preference.    2015 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:169-181).

title: Exposure to activity-based XXXX impairs contextual learning in weight-restored @entity1 without affecting spatial learning, taste, @entity2 , or dietary-fat preference.

answer: @entity3


abstract: UNASSIGNED: Relapse rates are high amongst @entity5 ( @entity5 ) suggesting that some alterations induced by @entity5 may remain after weight restoration. OBJECTIVE: To study the consequences of @entity5 without confounds of environmental variability, a rodent model of activity-based @entity3 (ABA) can be employed. We hypothesized that exposure to ABA during adolescence may have long-term consequences in taste function, cognition, and @entity2 -like behavior after weight restoration. METHODS: To test this hypothesis, we exposed adolescent female @entity1 to ABA (1.5 h food access, combined with @entity6 ) and compared their behavior to that of control @entity1 after weight restoration was achieved. The @entity1 were tested for learning/memory, @entity2 , food preference, and taste in a set of behavioral tests performed during the light period. RESULTS: Our data show that ABA exposure leads to reduced performance during the novel object recognition task, a test for contextual learning, without altering performance in the novel place recognition task or the Barnes maze, both tasks that test spatial learning. Furthermore, we do not observe alterations in unconditioned lick responses to @entity4 nor @entity7 (described by @entity0 as "sweet" and "bitter," respectively). Nor Do we find alterations in @entity2 -like behavior during an elevated plus maze or an open field test. Finally, preference for a diet high in fat is not altered. DISCUSSION: Overall, our data suggest that ABA exposure during adolescence impairs contextual learning in adulthood without altering spatial leaning, taste, @entity2 , or fat preference.    2015 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:169-181).

title: Exposure to activity-based @entity3 impairs contextual learning in weight-restored XXXX without affecting spatial learning, taste, @entity2 , or dietary-fat preference.

answer: @entity1


abstract: BACKGROUND: Recurrent @entity4 as a result of residual atrial arrhythmogenic substrates after @entity3 ( @entity3 ) ablation. In @entity0 with @entity3 , electrograms with reduced amplitudes indicate diseased myocardium. OBJECTIVE: The purpose of this study was to investigate the association between the distribution of low-voltage areas and the type of induced @entity4 . METHODS: Our prospective observational study enrolled 152 consecutive @entity3 @entity0 scheduled for an initial ablation (46% persistent @entity3 ). After @entity1 , voltage mapping was performed during sinus rhythm, and regions with reduced electrogram amplitudes (<0.5 mV) were defined as low-voltage areas. Burst pacing was performed to investigate the inducibility of @entity4 . RESULTS: Low-voltage areas were more frequently observed in @entity0 with persistent @entity3 than paroxysmal @entity3 (50% vs 34%, P = .048). A higher proportion of @entity0 with low-voltage areas presented with inducibility of @entity4 than those without, as follows: @entity3 70% vs 16% (P = .0001); perimitral macroreentrant @entity2 ( @entity2 ) 18% vs 0% (P = .0001); and roof-dependent macroreentrant @entity2 13% vs 0% (P = .01). Investigation into the regional distribution of low-voltage areas revealed that @entity0 with perimitral macroreentrant @entity2 more frequently coincided with low-voltage areas than those without in the septal (100% vs 18%, P <.0001) and anterior regions (55% vs 11%, P = .001), and those with roof-dependent @entity2 in the roof (75% vs 15%, P <.0001) and posterior regions (75% vs 15%, P = .0001). CONCLUSION: Low-voltage areas are associated with high inducibility of @entity4 after @entity1 . In addition, the distribution of low-voltage areas is specific for each type of macroreentrant @entity2 .

title: Influence of underlying substrate on @entity4 after XXXX .

answer: @entity1


abstract: BACKGROUND: Recurrent @entity4 as a result of residual atrial arrhythmogenic substrates after @entity3 ( @entity3 ) ablation. In @entity0 with @entity3 , electrograms with reduced amplitudes indicate diseased myocardium. OBJECTIVE: The purpose of this study was to investigate the association between the distribution of low-voltage areas and the type of induced @entity4 . METHODS: Our prospective observational study enrolled 152 consecutive @entity3 @entity0 scheduled for an initial ablation (46% persistent @entity3 ). After @entity1 , voltage mapping was performed during sinus rhythm, and regions with reduced electrogram amplitudes (<0.5 mV) were defined as low-voltage areas. Burst pacing was performed to investigate the inducibility of @entity4 . RESULTS: Low-voltage areas were more frequently observed in @entity0 with persistent @entity3 than paroxysmal @entity3 (50% vs 34%, P = .048). A higher proportion of @entity0 with low-voltage areas presented with inducibility of @entity4 than those without, as follows: @entity3 70% vs 16% (P = .0001); perimitral macroreentrant @entity2 ( @entity2 ) 18% vs 0% (P = .0001); and roof-dependent macroreentrant @entity2 13% vs 0% (P = .01). Investigation into the regional distribution of low-voltage areas revealed that @entity0 with perimitral macroreentrant @entity2 more frequently coincided with low-voltage areas than those without in the septal (100% vs 18%, P <.0001) and anterior regions (55% vs 11%, P = .001), and those with roof-dependent @entity2 in the roof (75% vs 15%, P <.0001) and posterior regions (75% vs 15%, P = .0001). CONCLUSION: Low-voltage areas are associated with high inducibility of @entity4 after @entity1 . In addition, the distribution of low-voltage areas is specific for each type of macroreentrant @entity2 .

title: Influence of underlying substrate on XXXX after @entity1 .

answer: @entity4


abstract: OBJECTIVE: To investigate the correlation between the lumbar vertebra @entity0 ( @entity0 ) and age, gender, height, weight, body mass index, waistline, hipline, bone marrow and abdomen fat, and to explore the key factor affecting the @entity0 . METHODS: A total of 72 cases were randomly recruited. All the subjects underwent a spectroscopic examination of the third lumber vertebra with single-voxel method in 1.5T MR. Lipid fractions (FF%) were measured. Quantitative CT were also performed to get the @entity0 of L3 and the corresponding abdomen @entity2 ( @entity2 ) and @entity2 ( @entity2 ). The statistical analysis were performed by SPSS 19.0. RESULTS: Multiple linear regression showed except the age and FF% showed significant difference (P<0.05) , the gender, height, weight, BMI, waistline, hipline, @entity2 and @entity2 showed no significant difference (P>0.05). The correlation of age and FF% with @entity0 was statistically negatively significant (r=-0.830, -0.521, P<0.05). The ROC curve analysis showed that the sensitivety and specificity of predicting @entity1 were 81.8% and 86.9%, with a threshold of 58.5 years old. And it showed that the sensitivety and specificity of predicting @entity1 were 90.9% and 55.7%, with a threshold of 52.8% for FF%. CONCLUSION: The lumbar vertebra @entity0 was significantly and negatively correlated with age and bone marrow FF%, but it was not significantly correlated with gender, height, weight, BMI, waistline, hipline, @entity2 and @entity2 . And age was the critical factor.

title: [Multiple linear regression and ROC curve analysis of the factors of lumbar spine XXXX ].

answer: @entity0


abstract: BACKGROUND: The Balance Evaluation Systems Test (BESTest) was recently created to allow the development of treatments according to the specific balance system affected in each @entity0 . The Brazilian version of the BESTest has not been specifically tested after @entity1 . OBJECTIVE: To evaluate the intra- and inter-rater reliability and concurrent and convergent validity of the total score of the BESTest and BESTest sections for adults with @entity2 after @entity1 . METHOD: The study included 16 subjects (61.1    7.5 years) with chronic @entity2 (54.5    43.5 months after @entity1 ). The BESTest was administered by two raters in the same week and one of the raters repeated the test after a one-week interval. Intraclass correlation coefficient (ICC) was calculated to assess intra- and interrater reliability. Concurrent validity with the Berg Balance Scale (BBS) and convergent validity with the Activities-specific Balance Confidence scale (ABC-Brazil) were assessed using Pearson's correlation coefficient. RESULTS: Both the BESTest total score (ICC=0.98) and the BESTest sections (ICC between 0.85 and 0.96) have excellent intrarater reliability. Interrater reliability for the total score was excellent (ICC=0.93) and, for the sections, it ranged between 0.71 and 0.94. The correlation coefficient between the BESTest and the BBS and ABC-Brazil were 0.78 and 0.59, respectively. CONCLUSIONS: The Brazilian version of the BESTest demonstrated adequate reliability when measured by sections and could identify what balance system was affected in @entity0 after @entity1 . Concurrent validity was excellent with the BBS total score and good to excellent with the sections. The total scores but not the sections present adequate convergent validity with the ABC-Brazil. However, other psychometric properties should be further investigated.

title: Reliability of the Balance Evaluation Systems Test (BESTest) and BESTest sections for adults with XXXX .

answer: @entity2


abstract: BACKGROUND: Transanal advancement flap repair fails in 1 of every 3 @entity0 with a high transsphincteric @entity2 . It has been reported that smoking, @entity1 , and previous attempts at repair adversely affect the outcome of transanal advancement flap repair. Because these findings could not be confirmed by other studies, it is still unclear whether these and other factors have an impact on the outcome. OBJECTIVE: The aim of this study was to identify predictors of outcome in a large cohort of @entity0 who underwent transanal advancement flap repair for a high transsphincteric @entity2 . DESIGN: This study was performed as a retrospective review. SETTINGS: The study was conducted at the Division of Colon and Rectal Surgery, Erasmus MC, between 2000 and 2012. @entity0 : A consecutive series of 252 @entity0 with a high transsphincteric @entity2 of cryptoglandular origin were included. @entity0 with a rectovaginal or Crohn @entity2 were excluded. INTERVENTIONS: All @entity0 underwent transanal advancement flap repair. Preoperatively, @entity0 underwent endoanal MRI. MAIN OUTCOME MEASURES: Healing was defined as complete wound healing with absence of symptoms. @entity0 were followed up to assess failure. Seventeen @entity0 - and @entity2 -related variables were assessed. RESULTS: Median duration of follow-up was 21 months (range, 6-136 months). The failure rate at 3 years was 41% (95% CI, 34-48). None of the studied variables predicted the outcome of flap repair except horseshoe extension. In univariate and multivariate analyses, significantly less failures were observed in @entity0 with a horseshoe extension (p < 0.05). LIMITATIONS: Retrospective design, a single surgeon series, and potential selection bias caused by the tertiary referral center status are the limitations of this study. CONCLUSIONS: Of all studied variables, horseshoe extension was found to be the only positive predictor of outcome after flap repair for high transsphincteric @entity2 .

title: Predictors of outcome after transanal advancement flap repair for high transsphincteric XXXX .

answer: @entity2


abstract: OBJECTIVES: This trial aimed to test the effectiveness of a wearable pulsed electromagnetic fields (PEMF) device in the management of @entity1 in knee @entity3 @entity0 . METHODS: In this randomized [with equal randomization (1:1)], double-blind, placebo-controlled clinical trial, @entity0 with radiographic evidence of knee @entity3 and persistent @entity1 higher than 40 mm on the visual analog scale (VAS) were recruited. The trial consisted of 12 h daily treatment for 1 month in 60 knee @entity3 @entity0 . The primary outcome measure was the reduction in @entity1 intensity, assessed through VAS and WOMAC scores. Secondary outcomes included quality of life assessment through the 36-item Medical Outcomes Study Short-Form version 2 (SF-36 v2), pressure @entity1 threshold (PPT) and changes in intake of NSAIDs/analgesics. RESULTS: Sixty-six @entity0 were included, and 60 completed the study. After 1 month, PEMF induced a significant reduction in @entity2 and WOMAC scores compared with placebo. Additionally, @entity1 tolerance, as expressed by PPT changes, and physical health improved in PEMF-treated @entity0 . A mean treatment effect of -0.73 (95% CI - 1.24 to - 0.19) was seen in VAS score, while the effect size was -0.34 (95% CI - 0.85 to 0.17) for WOMAC score. Twenty-six per cent of @entity0 in the PEMF group stopped NSAID/analgesic therapy. No adverse events were detected. CONCLUSION: These results suggest that PEMF therapy is effective for @entity1 management in knee @entity3 @entity0 and also affects @entity1 threshold and physical functioning. Future larger studies, including head-to-head studies comparing PEMF therapy with standard pharmacological approaches in @entity3 , are warranted. TRIAL REGISTRATION: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT01877278.

title: Pulsed electromagnetic fields in knee XXXX : a double blind, placebo-controlled, randomized clinical trial.

answer: @entity3


abstract: PURPOSE OF REVIEW: Provide an evidence-based resource for the surveillance of @entity3 lesions, focusing on the scientific articles reported recently. RECENT FINDINGS: No randomized controlled clinical trials exist to definitively support the efficacy of surveillance programs for @entity4 and @entity5 . However, surveillance of these @entity2 is recommended by some of the leading organizations. To optimize the usefulness of surveillance programs, targeting high-risk @entity0 might maximize its benefits. A @entity4 segment of at least 3cm and evidence of @entity8 can help stratify those @entity0 at highest risk for progression to @entity6 . The location, extent, and severity of @entity8 are indicators of risk of developing @entity5 . @entity0 with extensive @entity8 should be offered endoscopic surveillance. Quality in the baseline colonoscopy is crucial to decrease the risk of interval @entity1 . The importance of serrated @entity7 , as well as their surveillance intervals, is emphasized. SUMMARY: To optimize the usefulness of surveillance programs, targeting high-risk @entity0 might maximize its benefits. Future research is needed to design more effective surveillance strategies. Recently, emerging imaging techniques hold promise for improving sensitivity of endoscopic surveillance of premalignant conditions in the gastrointestinal tract.

title: Endoscopic surveillance of XXXX lesions: current knowledge and future directions.

answer: @entity3


abstract: OBJECTIVE: Several studies have demonstrated that soy isoflavone (SIF) supplementation can improve aspects of cognitive function. However, these findings remain controversial. We aimed to quantify the effects of SIF supplementation on improving cognitive function in postmenopausal @entity0 . METHODS: Databases and relevant Websites were searched for relevant studies up to March 2014. Two reviewers independently verified all potentially suitable @entity1 ( @entity1 ) using inclusion and exclusion criteria, and the quality of identified @entity1 was assessed using the Jadad scale and the Risk of Bias Tool from the "Cochrane handbook for systematic reviews of interventions." Any disagreement on study quality or data extraction was resolved by consensus; a third reviewer was consulted if needed. Standardized mean differences (SMDs) in cognitive function test scores were calculated between SIF-treated and placebo-treated groups. RESULTS: We conducted a meta-analysis of 10 placebo-controlled @entity1 of SIF supplementation (1,024 @entity0 ; treatment duration of 6 wk to 30 mo). The overall @entity4 in summary cognitive function test scores (0.08) was statistically significant (95% CI, 0.02-0.15; P = 0.014). The summary @entity4 for visual memory (0.10) was statistically significant (95% CI, 0.02-0.18; P = 0.016). In subgroup analyses, the statistically significant SMDs were as follows: 0.12 (95% CI, 0-0.25; P = 0.044) for non-US countries; 0.16 (95% CI, 0.05-0.28; P = 0.004) for mean age younger than 60 years; and 0.15 (95% CI, 0.03-0.27; P = 0.011) for treatment duration less than 12 months. CONCLUSIONS: SIF supplementation seems to have a positive effect on improving summary cognitive function and visual memory in postmenopausal @entity0 . There may be a critical window of opportunity in initiating SIF use at an earlier age in postmenopausal @entity0 , and geography and treatment duration seem to be factors influencing the effects of SIF supplementation. All individuals in the included studies should be followed up to observe the incidence rates of @entity2 and @entity3 , and future studies should report any adverse effects of SIF supplementation.

title: Do soy isoflavones improve cognitive function in postmenopausal XXXX ? A meta-analysis.

answer: @entity0


abstract: BACKGROUND/AIMS: We aimed to investigate the efficacy and tolerability of a FOLFOX7 regimen in the first-line treatment of metastatic @entity2 (mCRC) @entity0 . MATERIALS AND METHODS: @entity0 were evaluated in two groups. Group A did not receive any treatment before, and group B had metastasectomy or metastasectomy plus @entity1 resection. RESULTS: In total, 132 mCRC @entity0 had received FOLFOX7 regimen. The A group consisted of 117 (88.6%) @entity0 , and group B consisted of 15 (11.4%) @entity0 . In the A group, 52.1% had an objective response, 9.4% complete response, 42.7% partial response, 24.8% stable response, and 23.1% progression, and there was a 54.5% rate of @entity1 resection, 22.2% rate of metastasectomy, 80.7% rate of R0 metastasectomy, 19.1% rate of R1 metastasectomy, 15 (10-19) months median progression-free survival, and 32 (22-41) months median overall survival. In the B group, 40 (4-70) months median disease-free survival and 58 (21-94) months median overall survival were found. When @entity3 were evaluated, grade 3/4 @entity3 was observed in 35.6%. Grade 3/4 hematologic @entity3 was the most frequently observed @entity3 (29.5%). CONCLUSION: FOLFOX7 regimen was found to be an efficient and safe regimen for the first-line treatment of mCRC @entity0 .

title: FOLFOX7 regimen in the first-line treatment of metastatic XXXX .

answer: @entity2


abstract: BACKGROUND: Many studies have demonstrated the efficacy of @entity4 / @entity5 (BUD/FORM) for Maintenance and Reliever Therapy (SMART  ) for @entity3 control. However, there are concerns regarding its over-use and effectiveness. OBJECTIVE: To examine @entity3 control and over-use of BUD/FORM in real-life situations. METHODS: This study was a hospital-based cross-sectional and multi-center design. @entity0 were enrolled if they were >12 years old, had persistent @entity3 , had received BUD/FORM SMART for 3 months or longer, and smoked less than 10 pack-year. RESULTS: Of the 792 @entity0 who used BUD/FORM for a mean of 28.2 months, all used BUD/FORM as maintenance and only 22.2% of the @entity0 required BUD/FORM to relieve symptoms. The average inhaled @entity2 dose used was 355.3  154.9 g/day (95% CI: 344.5 to 366.1). In 792 @entity0 , constituting 2,376 @entity0 -months of observations, there was only one @entity0 who used more than 12 puffs/ day of BUD/FORM for 3 days, with a rate of 0.015 days per @entity0 per year (95%CI: 0.003 to 0.044), without reporting any adverse events. The percentage of @entity3 control according to the Asthma Control Test score of 20 or greater was 86.5% (95% CI: 84.1 to 88.9). Overall, the rates per @entity0 per year of emergency room (ER) visits and hospital admissions were 0.18 and 0.21, respectively. CONCLUSIONS: BUD/FORM SMART is effective in real-life clinical practice. On average, @entity0 who received a low dose @entity1 in the form of BUD/FORM, had a satisfactorily high proportion of @entity3 control and had a low rate of ER visits and hospitalization. BUD/FORM maintenance and reliever therapy seems to be promising as a treatment approach for persistent @entity3 in every day clinical practice.

title: Role of @entity4 / XXXX maintenance and reliever therapy: a pragmatic study.

answer: @entity5


abstract: BACKGROUND: Many studies have demonstrated the efficacy of @entity4 / @entity5 (BUD/FORM) for Maintenance and Reliever Therapy (SMART  ) for @entity3 control. However, there are concerns regarding its over-use and effectiveness. OBJECTIVE: To examine @entity3 control and over-use of BUD/FORM in real-life situations. METHODS: This study was a hospital-based cross-sectional and multi-center design. @entity0 were enrolled if they were >12 years old, had persistent @entity3 , had received BUD/FORM SMART for 3 months or longer, and smoked less than 10 pack-year. RESULTS: Of the 792 @entity0 who used BUD/FORM for a mean of 28.2 months, all used BUD/FORM as maintenance and only 22.2% of the @entity0 required BUD/FORM to relieve symptoms. The average inhaled @entity2 dose used was 355.3  154.9 g/day (95% CI: 344.5 to 366.1). In 792 @entity0 , constituting 2,376 @entity0 -months of observations, there was only one @entity0 who used more than 12 puffs/ day of BUD/FORM for 3 days, with a rate of 0.015 days per @entity0 per year (95%CI: 0.003 to 0.044), without reporting any adverse events. The percentage of @entity3 control according to the Asthma Control Test score of 20 or greater was 86.5% (95% CI: 84.1 to 88.9). Overall, the rates per @entity0 per year of emergency room (ER) visits and hospital admissions were 0.18 and 0.21, respectively. CONCLUSIONS: BUD/FORM SMART is effective in real-life clinical practice. On average, @entity0 who received a low dose @entity1 in the form of BUD/FORM, had a satisfactorily high proportion of @entity3 control and had a low rate of ER visits and hospitalization. BUD/FORM maintenance and reliever therapy seems to be promising as a treatment approach for persistent @entity3 in every day clinical practice.

title: Role of XXXX / @entity5 maintenance and reliever therapy: a pragmatic study.

answer: @entity4


abstract: UNASSIGNED: Raising @entity3 in settings that are highly contaminated with oocysts of @entity4 may contribute significantly to @entity0 exposure to this zoonotic parasite. Increasing consumption of young @entity3 in countries where @entity3 are frequently reared in backyards that are also homes to @entity2 (the definitive host of this parasite) elevates such concern. To date, there has been little attention to either the prevalence or genotypic characteristics of @entity4 isolates in young ruminant food animals in Europe. Here, we estimated the prevalence of @entity4 @entity3 -kids raised in backyards and slaughtered for @entity0 consumption during Easter. We collected 181 paired samples of serum and diaphragm. Serum samples were analyzed by enzyme-linked immunosorbent assay for antibodies against @entity4 , and muscle tissues were analyzed by polymerase chain reaction to detect @entity4 DNA. Thirty-two diaphragm samples were also bioassayed in @entity1 , and the isolates were genotyped using microsatellite markers. The overall seroprevalence of @entity4 infection in @entity3 -kids was 33.1% (60/181; 95% confidence interval [CI] 26.3-40.5%), and @entity4 DNA was found in 6.1% (11/181; 95% CI 3.1-10.6) of the diaphragm samples. We isolated the parasite from 2 of 32 @entity3 -kids, and the @entity4 strains belonged to genotype II. The results showed that 1/3 of 3-mo-old @entity3 may be infected with @entity4 , and their consumption during Easter (as barbecue) may seriously compromise food safety as a result.

title: Traditional XXXX Husbandry May Substantially Contribute to @entity0 Toxoplasmosis Exposure.

answer: @entity3


abstract: UNASSIGNED: Raising @entity3 in settings that are highly contaminated with oocysts of @entity4 may contribute significantly to @entity0 exposure to this zoonotic parasite. Increasing consumption of young @entity3 in countries where @entity3 are frequently reared in backyards that are also homes to @entity2 (the definitive host of this parasite) elevates such concern. To date, there has been little attention to either the prevalence or genotypic characteristics of @entity4 isolates in young ruminant food animals in Europe. Here, we estimated the prevalence of @entity4 @entity3 -kids raised in backyards and slaughtered for @entity0 consumption during Easter. We collected 181 paired samples of serum and diaphragm. Serum samples were analyzed by enzyme-linked immunosorbent assay for antibodies against @entity4 , and muscle tissues were analyzed by polymerase chain reaction to detect @entity4 DNA. Thirty-two diaphragm samples were also bioassayed in @entity1 , and the isolates were genotyped using microsatellite markers. The overall seroprevalence of @entity4 infection in @entity3 -kids was 33.1% (60/181; 95% confidence interval [CI] 26.3-40.5%), and @entity4 DNA was found in 6.1% (11/181; 95% CI 3.1-10.6) of the diaphragm samples. We isolated the parasite from 2 of 32 @entity3 -kids, and the @entity4 strains belonged to genotype II. The results showed that 1/3 of 3-mo-old @entity3 may be infected with @entity4 , and their consumption during Easter (as barbecue) may seriously compromise food safety as a result.

title: Traditional @entity3 Husbandry May Substantially Contribute to XXXX Toxoplasmosis Exposure.

answer: @entity0


abstract: BACKGROUND: @entity1 ( @entity1 ) is a highly contagious infection of the airways, presenting mostly in connection with common cold (CC). There is a high variance in duration and course of symptoms which, sooner or later, also may disappear spontaneously and change during the course of the disease. Therefore, assessment of treatment outcome is difficult. METHODS: Composite outcome measures are commonly used to examine the effects of pharmacotherapy in complex diseases. We discuss the features of the @entity2 ( @entity2 ) on the basis of the available literature. RESULTS: For the @entity2 the five most important symptoms of @entity1 are rated by the @entity0 and the physician. Since its introduction in 1996, the @entity2 has been used in many clinical trials evaluating treatment effects of @entity1 . Its score correlates well with clinical findings. As thorough validation analyses revealed, this applies even more to the @entity2 subscales "cough domain" and "sputum domain". CONCLUSION: The validated @entity2 appears to be a reliable tool to assess therapeutic effects in CC/ @entity1 . The @entity2 and its subscales are recommended as outcome measures for future drug trials in CC/ @entity1 , but also help physicians to focus their consultation in @entity0 with CC/ @entity1 .

title: Assessment of the effect of pharmacotherapy in common cold/acute @entity2 - the XXXX ( @entity2 ).

answer: @entity2


abstract: BACKGROUND: @entity1 ( @entity1 ) is a highly contagious infection of the airways, presenting mostly in connection with common cold (CC). There is a high variance in duration and course of symptoms which, sooner or later, also may disappear spontaneously and change during the course of the disease. Therefore, assessment of treatment outcome is difficult. METHODS: Composite outcome measures are commonly used to examine the effects of pharmacotherapy in complex diseases. We discuss the features of the @entity2 ( @entity2 ) on the basis of the available literature. RESULTS: For the @entity2 the five most important symptoms of @entity1 are rated by the @entity0 and the physician. Since its introduction in 1996, the @entity2 has been used in many clinical trials evaluating treatment effects of @entity1 . Its score correlates well with clinical findings. As thorough validation analyses revealed, this applies even more to the @entity2 subscales "cough domain" and "sputum domain". CONCLUSION: The validated @entity2 appears to be a reliable tool to assess therapeutic effects in CC/ @entity1 . The @entity2 and its subscales are recommended as outcome measures for future drug trials in CC/ @entity1 , but also help physicians to focus their consultation in @entity0 with CC/ @entity1 .

title: Assessment of the effect of pharmacotherapy in common cold/acute XXXX - the @entity2 ( @entity2 ).

answer: @entity2


abstract: BACKGROUND: @entity1 ( @entity1 ) is a highly contagious infection of the airways, presenting mostly in connection with common cold (CC). There is a high variance in duration and course of symptoms which, sooner or later, also may disappear spontaneously and change during the course of the disease. Therefore, assessment of treatment outcome is difficult. METHODS: Composite outcome measures are commonly used to examine the effects of pharmacotherapy in complex diseases. We discuss the features of the @entity2 ( @entity2 ) on the basis of the available literature. RESULTS: For the @entity2 the five most important symptoms of @entity1 are rated by the @entity0 and the physician. Since its introduction in 1996, the @entity2 has been used in many clinical trials evaluating treatment effects of @entity1 . Its score correlates well with clinical findings. As thorough validation analyses revealed, this applies even more to the @entity2 subscales "cough domain" and "sputum domain". CONCLUSION: The validated @entity2 appears to be a reliable tool to assess therapeutic effects in CC/ @entity1 . The @entity2 and its subscales are recommended as outcome measures for future drug trials in CC/ @entity1 , but also help physicians to focus their consultation in @entity0 with CC/ @entity1 .

title: Assessment of the effect of pharmacotherapy in common cold/acute @entity2 - the @entity2 ( XXXX ).

answer: @entity2


abstract: PURPOSE: Rituximab maintenance therapy has been shown to improve progression-free survival in @entity0 with @entity2 ; however, the optimal duration of maintenance treatment remains unknown. @entity0 AND METHODS: Two hundred seventy @entity0 with untreated, relapsed, stable, or chemotherapy-resistant @entity2 were treated with four doses of rituximab monotherapy in weekly intervals (375 mg/m(2)). @entity0 achieving at least a partial response were randomly assigned to receive maintenance therapy with one infusion of rituximab every 2 months, either on a short-term schedule (four administrations) or a long-term schedule (maximum of 5 years or until disease progression or unacceptable @entity1 ). The primary end point was event-free survival (EFS). Progression-free survival, @entity3 ( @entity3 ), and @entity1 were secondary end points. Comparisons between the two arms were performed using the log-rank test for survival end points. RESULTS: One hundred sixty-five @entity0 were randomly assigned to the short-term (n = 82) or long-term (n = 83) maintenance arms. Because of the low event rate, the final analysis was performed after 95 events had occurred, which was before the targeted event number of 99 had been reached. At a median follow-up period of 6.4 years, the median EFS was 3.4 years (95% CI, 2.1 to 5.3) in the short-term arm and 5.3 years (95% CI, 3.5 to not available) in the long-term arm (P = .14). @entity0 in the long-term arm experienced more adverse effects than did those in the short-term arm, with 76% v 50% of @entity0 with at least one adverse event (P < .001), five versus one @entity0 with grade 3 and 4 infections, and three versus zero @entity0 discontinuing treatment because of unacceptable @entity1 , respectively. There was no difference in @entity3 between the two groups. CONCLUSION: Long-term rituximab maintenance therapy does not improve EFS, which was the primary end point of this trial, or @entity3 , and was associated with increased @entity1 .

title: Rituximab Maintenance for a Maximum of 5 Years After Single-Agent Rituximab Induction in XXXX : Results of the Randomized Controlled Phase III Trial SAKK 35/03.

answer: @entity2


abstract: OBJECTIVE:: Intravenous (IV) @entity0 is the preferred cytochrome P450 (CYP) 3A probe for phenotyping, with systemic clearance (CL) estimating hepatic @entity1 activity. A limited sampling strategy was conducted to determine whether partial area under the concentration-time curves (AUCs) could reliably estimate @entity0 systemic CL during conditions of @entity1 baseline activity, inhibition, and induction/activation. METHODS:: @entity0 plasma concentrations during @entity1 baseline (n = 93), inhibition (n = 40), and induction/activation (n = 33) were obtained from 7 studies in healthy adults. Noncompartmental analysis determined observed CL (CLobs) and partial AUCs. Linear regression equations were derived from partial AUCs to estimate CL (CLpred) during @entity1 baseline, inhibition, and induction/activation. Preestablished criterion for linear regression analysis was r >=  0.9. CLpred was compared with CLobs, and relative bias and precision were assessed using percent mean prediction error and percent mean absolute error. RESULTS:: During @entity1 baseline and inhibition, all evaluated partial AUCs failed to meet criterion of r >=  0.9 and/or percent mean absolute error <15%. During @entity1 induction/activation, equations derived from partial AUCs from 0 to 1 hour (AUC0-1), 0 to 2 hours (AUC0-2), and 0 to 4 hours (AUC0-4) were acceptable, with good precision and minimal bias. These equations provided the same conclusions regarding equivalency testing compared with intense sampling. CONCLUSIONS:: During @entity1 induction/activation, but not baseline or inhibition, @entity0 partial AUC0-1, AUC0-2, and AUC0-4 reliably estimated systemic CL and consequently hepatic @entity1 activity in healthy adults.

title: Limited Sampling Strategy of Partial Area Under the Concentration-Time Curves to Estimate XXXX Systemic Clearance for Cytochrome P450 3A Phenotyping.

answer: @entity0


abstract: OBJECTIVES: The Hospital Readmissions Reduction Program mandates reimbursement reductions to hospitals with higher than expected rates of readmissions. We examine causes and predictors of readmissions following major procedures in urologic oncology. MATERIALS AND METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program database, @entity0 undergoing radical prostatectomy (RP), radical (RN) or @entity8 ( @entity8 ), and radical cystectomy (RC) during the year 2012 were abstracted. Rates of unplanned readmission within 30 days after surgery, as well as causes of readmission, were identified. Multivariable logistic regression models were fitted to examine the association between @entity0 perioperative factors and odds of readmission. RESULTS: Overall, we observed a 5.5% unplanned 30-day readmission rate. Readmission rates for @entity0 treated with RP, RN, @entity8 , and RC were 4.1%, 5.2%, 4.5%, and 15.9%, respectively. For each procedure, approximately two-third of readmissions occurred within the first 10 days following hospital discharge. Commonest causes of readmission after RP included @entity5 (13.6%), wound (12.2%), renal/genitourinary (12.2%), and gastrointestinal (11.8%); after RN, wound (12.9%) and gastrointestinal (12.9%); after @entity8 , renal/genitourinary (19.6%), cardiovascular (9.8%), and @entity4 / @entity7 (9.8%); and after RC, renal/genitourinary (15.5%), wound (14.8%), and @entity3 / @entity2 (14.1%). RC was significantly associated with readmission. @entity0 undergoing open RP or @entity8 were more likely to be readmitted relative to their minimally invasive counterparts (odds ratio = 1.53, 95% CI: 1.12-2.08, P = 0.007 and odds ratio = 2.51, 95% CI: 1.38-4.55, P = 0.003, respectively). CONCLUSIONS: Readmissions are relatively common following major urologic oncology procedures. Compared with RP, RN, or @entity8 , RC @entity0 experience the highest burden of readmission. @entity6 is a common modifiable cause of readmission following @entity1 surgery. Minimally invasive approach is associated with decreased odds of readmission following RP and @entity8 .

title: Causes of hospital readmissions after XXXX surgery.

answer: @entity1


abstract: BACKGROUND: The @entity5 represent about 70% of perianal suppuration, with an estimated incidence of 1/10000 inhabitants per year and representing 5% of queries in coloproctology. AIM: To evaluate the effectiveness of the interesphincteric ligation technique of the fistulous tract in the treatment of @entity5 . METHODS: The records of eight @entity0 who underwent this technique, evaluating age, gender and presence of @entity2 were studied. Was named technical first-step the passage of @entity4 thread to promote the correct individualization of the @entity1 and, as the second, the surgical procedure. RESULTS: Two @entity0 were @entity0 and eight @entity0 . The mean age was 42.8 years. Of these, seven (87.5%) had complete healing of the @entity1 ; six were cured only with this procedure and one required additional operation with simple fistulotomy. Only one @entity0 developed @entity3 which was documented by anorectal manometry. There were no deaths in this series. CONCLUSION: The interesphincteric ligation technique of the fistulous tract proved to be effective for the treatment of @entity5 and should not be discouraged despite the occurrence of eventual @entity3 .

title: Effectiveness of the ligation of intersphincteric @entity1 tract (LIFT) in the treatment of XXXX : initial results.

answer: @entity5


abstract: BACKGROUND: The @entity5 represent about 70% of perianal suppuration, with an estimated incidence of 1/10000 inhabitants per year and representing 5% of queries in coloproctology. AIM: To evaluate the effectiveness of the interesphincteric ligation technique of the fistulous tract in the treatment of @entity5 . METHODS: The records of eight @entity0 who underwent this technique, evaluating age, gender and presence of @entity2 were studied. Was named technical first-step the passage of @entity4 thread to promote the correct individualization of the @entity1 and, as the second, the surgical procedure. RESULTS: Two @entity0 were @entity0 and eight @entity0 . The mean age was 42.8 years. Of these, seven (87.5%) had complete healing of the @entity1 ; six were cured only with this procedure and one required additional operation with simple fistulotomy. Only one @entity0 developed @entity3 which was documented by anorectal manometry. There were no deaths in this series. CONCLUSION: The interesphincteric ligation technique of the fistulous tract proved to be effective for the treatment of @entity5 and should not be discouraged despite the occurrence of eventual @entity3 .

title: Effectiveness of the ligation of intersphincteric XXXX tract (LIFT) in the treatment of @entity5 : initial results.

answer: @entity1


abstract: BACKGROUND: @entity2 is a major cause of morbidity and mortality and can arise through the adenoma- @entity3 sequence. Colonoscopy is considered the method of choice for population-wide @entity1 screening. AIM: To assess the characteristics of endoscopically resected @entity5 in a consecutive series of @entity0 who underwent colonoscopy at a university hospital and compare histopathology findings according to @entity0 age and polyp size. METHODS: Retrospective, cross-sectional of 1950 colonoscopy reports from consecutively examined @entity0 . The sample was restricted to reports that mentioned @entity5 . A chart review was carried out for collection of demographic data and histopathology results. Data were compared for @entity5 sized  <=0.5 cm and >= 0.6 cm and then for @entity5 sized  <=1.0 cm and >= 1.1 cm. Finally, all @entity5 resected from @entity0 aged 49 years or younger were compared with those resected from @entity0 aged 50 years or older. RESULTS: A total of 272 @entity5 were resected in 224 of the 1950 colonoscopies included in the sample (11.5%). Polyps >1 cm tended to be pedunculated (p=0.000) and were more likely to exhibit an adenomatous component (p=0.001), a villous component (p=0.000), and @entity6 (p=0.003). These findings held true when the size cutoff was set at 0.5 cm. @entity0 aged 50 years or older were more likely to have sessile @entity5 (p=0.023) and @entity5 located in the proximal colon (p=0.009). There were no significant differences between groups in histopathology or presence of @entity6 . CONCLUSION: Polyp size is associated with presence of @entity4 , a villous component, and @entity6 , whereas @entity0 age is more frequently associated with sessile @entity5 in the proximal colon.

title: Influence of XXXX age and colorectal polyp size on histopathology findings.

answer: @entity0


abstract: OBJECTIVE: To investigate the value of three-dimentional pseudo-continuous arterial spin labeling (ASL) perfusion imaging in differentiating @entity3 from acute @entity2 . METHODS: From September 2013 to September 2014, 42 @entity0 with actue @entity1 onset and 20 healthy volunteers underwent conventional brain MRI DWI and 3D-ASL Perfusion Imaging in our hospital. Only 20 @entity0 whose lesions located in the middle cerebral artery (MCA) territory were enrolled in this study. Of these cases, 12 cases were diagnosed with @entity3 , 8 were diagnosed with @entity2 . First, we analyzed the imaging features of the 20 @entity0 and 20 volunteers. Then, CBF values of the lesions in the 20 @entity0 and the gray matter of MCA territory in the 20 volunteers were measured on 3D-pcASL images. Third, the difference of mean CBF values between @entity0 and volunteers were analyzed. RESULTS: Out of 20 study group, 19 @entity0 whose lesions presented high signal intensity on DWI images, 12 cases were @entity3 and 8 were @entity2 . All the lesions of 20 cases showed abnormal perfusion on 3D-pcASL images. 3D-pcASL has good consistency with DWI in diagnostic capabilities (  (2) = 0.565, P = 0.01). On 3D-pcASL, 11 @entity3 @entity0 presented perfusion defects or low perfusion, 1 @entity3 @entity0 showed high perfusion, 8 @entity2 @entity0 showed inhomogeneous perfusion. The mean value of CBF was (17    6) ml    @entity4 )    100 g(-1) in 12 @entity3 @entity0 , (136    69) ml    @entity4 )    100 g(-1) in 8 @entity2 @entity0 and (68    12) ml    @entity4 )    100 g(-1) three in 20 healthy volunteers. The difference in mean value of CBF among the three groups was statistically significant (P < 0.01). CONCLUSION: Acute @entity3 often shows low perfusion and acute @entity2 shows high perfusion on 3D-pcASL images, which has a higher application value in diagnosis and differentiation of @entity3 and @entity2 .

title: [Study of 3D-pcASL in differentiation of @entity3 and acute XXXX ].

answer: @entity2


abstract: OBJECTIVE: To investigate the value of three-dimentional pseudo-continuous arterial spin labeling (ASL) perfusion imaging in differentiating @entity3 from acute @entity2 . METHODS: From September 2013 to September 2014, 42 @entity0 with actue @entity1 onset and 20 healthy volunteers underwent conventional brain MRI DWI and 3D-ASL Perfusion Imaging in our hospital. Only 20 @entity0 whose lesions located in the middle cerebral artery (MCA) territory were enrolled in this study. Of these cases, 12 cases were diagnosed with @entity3 , 8 were diagnosed with @entity2 . First, we analyzed the imaging features of the 20 @entity0 and 20 volunteers. Then, CBF values of the lesions in the 20 @entity0 and the gray matter of MCA territory in the 20 volunteers were measured on 3D-pcASL images. Third, the difference of mean CBF values between @entity0 and volunteers were analyzed. RESULTS: Out of 20 study group, 19 @entity0 whose lesions presented high signal intensity on DWI images, 12 cases were @entity3 and 8 were @entity2 . All the lesions of 20 cases showed abnormal perfusion on 3D-pcASL images. 3D-pcASL has good consistency with DWI in diagnostic capabilities (  (2) = 0.565, P = 0.01). On 3D-pcASL, 11 @entity3 @entity0 presented perfusion defects or low perfusion, 1 @entity3 @entity0 showed high perfusion, 8 @entity2 @entity0 showed inhomogeneous perfusion. The mean value of CBF was (17    6) ml    @entity4 )    100 g(-1) in 12 @entity3 @entity0 , (136    69) ml    @entity4 )    100 g(-1) in 8 @entity2 @entity0 and (68    12) ml    @entity4 )    100 g(-1) three in 20 healthy volunteers. The difference in mean value of CBF among the three groups was statistically significant (P < 0.01). CONCLUSION: Acute @entity3 often shows low perfusion and acute @entity2 shows high perfusion on 3D-pcASL images, which has a higher application value in diagnosis and differentiation of @entity3 and @entity2 .

title: [Study of 3D-pcASL in differentiation of XXXX and acute @entity2 ].

answer: @entity3


abstract: BACKGROUND: Caregiving roles of @entity0 <18 years of age living with parents with health conditions or disability have been studied extensively abroad, but little U.S. research has examined the caregiving activities and perceptions of @entity0 with parents with significant @entity1 . OBJECTIVE: To examine @entity0 's caregiving activities for their disabled parent, childhood perceptions of these activities, and adult views of this caregiving. METHODS: We conducted 1-h, semi-structured, open-ended interviews with 20 @entity0 age >= 21 years who as @entity0 (age  <  18 years) had a parent with significant @entity1 . We used conventional content analysis to identify themes. RESULTS: Interviewees' mean (standard deviation) age was 36.7 (13.8) years; 4 were male. As @entity0 , most interviewees assisted their disabled parent with activities of daily living (ADLs) and instrumental ADLs; some @entity0 provided more medical supports. Several parents, especially of older interviewees, did not seek their @entity0 's care. Interviewees reported both positive and negative childhood attitudes about caregiving. Roughly half recalled as @entity0 feeling proud, special, or otherwise positively toward caregiving activities, while about one-third viewed caregiving as just part of their daily reality (i.e., simply needing to be done). Approximately half remembered also feeling resentful, primarily from time demands, insufficient appreciation, and being different from their peers. Interviewees reported gender and cultural factors affecting their caregiving roles and perceptions. CONCLUSIONS: @entity0 can provide significant care to parents with @entity1 . Understanding better their roles and perceptions could suggest ways to improve these experiences for both @entity0 and parent.

title: Adults' recollections and perceptions of childhood caregiving to a parent with significant XXXX .

answer: @entity1


abstract: BACKGROUND: The aim of this study was to describe the nutrition, food choice, physical activity and weight status in a group of adults with @entity2 ( @entity2 ) in Victoria, Australia. METHOD: Disability workers and adults with @entity2 were recruited through disability services. In total, 51 disability workers (11 @entity0 , 40 @entity0 ) and 68 (47 @entity0 , 21 @entity0 ) adults with @entity2 participated in the research. Disability workers provided information about the nutrition, food choice and physical activity levels of adults with @entity2 through a questionnaire administered by a general practitioner or research nurse. The questionnaire also included The Australian Nutrition Screening Initiative checklist. RESULTS: Body Mass Index was in the healthy range for only 37.5% of @entity0 and in the @entity1 range for almost half (41%). Similarly, the majority of @entity0 had an abdominal circumference in a range that put them at increased or substantially increased risk of metabolic complications. The mean score obtained on the Australian Nutrition Screening Initiative checklist indicated a moderate risk of @entity3 (M   =   4.2); however, 17.6% of @entity0 achieved scores that put them in the high-risk category. More than half of the @entity0 were reported to have a little choice in the type of food they ate and when they ate. Physical activity data indicated that the majority of @entity0 (60.3%) did not meet national physical activity guidelines. CONCLUSIONS: These findings suggest that @entity0 with @entity2 are at risk of developing diseases associated with @entity1 , inactivity, and poor nutrition. Strategies to encourage @entity0 with @entity2 to engage in physical activity and healthy eating are, therefore, a matter of priority and should involve their disability workers.

title: Weight, nutrition, food choice, and physical activity in adults with XXXX .

answer: @entity2


abstract: OBJECTIVES: Determine the overall mortality after @entity2 and compare it to the overall mortality afterothrombotic and @entity0 . Determine the pattern of increased mortality over time after @entity2 . METHODS: The clinical literature was searched for articles providing mortality data on @entity2 having at least 5 years of @entity0 follow up. Three such articles were identified two of which also had @entity0 mortality data on the other two types of @entity1 , atherothrombotic and @entity0 . Degree of overall increased mortality was determined for all three @entity0 types and increased mortality over time was determined for @entity2 as well. Standard mortality methodology was used and expectant mortality was determined using appropriate population life tables. Average overall mortality ratios (MR) and average overall excess deaths per thousand per year ( @entity3 ) were determined by weighting for the number of entrants in each study. RESULTS: The average overall MR for @entity2 = 159%, for @entity0 = 213% and for @entity0 = 322%. The mortality ratios for @entity2 for the following post- @entity0 intervals were: 1-5 years = 166%; 6-10 years = 153%; and 11-14 years = 106%. CONCLUSIONS: @entity2 from onset is associated with moderately increased overall mortality relative to the general population. Post- @entity0 mortality risks from atherothrombotic and @entity0 are significantly higher.

title: XXXX , mortality over time and mortality relative to other @entity1 .

answer: @entity2


abstract: OBJECTIVES: Determine the overall mortality after @entity2 and compare it to the overall mortality afterothrombotic and @entity0 . Determine the pattern of increased mortality over time after @entity2 . METHODS: The clinical literature was searched for articles providing mortality data on @entity2 having at least 5 years of @entity0 follow up. Three such articles were identified two of which also had @entity0 mortality data on the other two types of @entity1 , atherothrombotic and @entity0 . Degree of overall increased mortality was determined for all three @entity0 types and increased mortality over time was determined for @entity2 as well. Standard mortality methodology was used and expectant mortality was determined using appropriate population life tables. Average overall mortality ratios (MR) and average overall excess deaths per thousand per year ( @entity3 ) were determined by weighting for the number of entrants in each study. RESULTS: The average overall MR for @entity2 = 159%, for @entity0 = 213% and for @entity0 = 322%. The mortality ratios for @entity2 for the following post- @entity0 intervals were: 1-5 years = 166%; 6-10 years = 153%; and 11-14 years = 106%. CONCLUSIONS: @entity2 from onset is associated with moderately increased overall mortality relative to the general population. Post- @entity0 mortality risks from atherothrombotic and @entity0 are significantly higher.

title: @entity2 , mortality over time and mortality relative to other XXXX .

answer: @entity1


abstract: UNASSIGNED: Despite decreasing rates of invasive @entity4 caused by vaccine serotypes, the prevalence of invasive @entity10 in @entity9 @entity0 remains high. However, little is known about the mechanisms underlying the susceptibility of the @entity9 airway to @entity12 . In this study, we used a combined model of @entity3 airway @entity2 and @entity6 @entity7 to investigate the association between persistent @entity2 in the airway and antibacterial host defenses against @entity11 . When challenged with @entity11 , @entity3 @entity1 exhibited higher airway bacterial burdens, greater eosinophil infiltration, lower neutrophil infiltration, and more severe structural damage than non- @entity3 @entity1 . In sensitized @entity1 , @entity11 @entity5 elicited higher IL-4 but lower IFN-y, @entity8 and defensin-b2 expression than in control @entity1 . These results indicate that persistent @entity2 impaired airway host defense against @entity11 is associated with the insufficient @entity8 responses. To elicit @entity8 induced-anti-bacterial immune responses, @entity1 were intranasally immunized with @entity13 . Immunized @entity1 exhibited fewer bacterial colonies in the respiratory tract and less severe lung pathology than unimmunized @entity1 . @entity13 contributed to airway host defense enhancement and innate immune response promotion, which was associated with increased @entity15 , @entity14 and defensin-b2 expression. Administration of exogenous @entity8 (2 g/ @entity1 ) suppressed eosinophil-related immune responses. The results demonstrate @entity8 plays a key role in host defenses against @entity12 and suggest that exogenous @entity8 administration promotes the anti-becterial immune responses and attenuates the existed @entity2 .

title: Allergic airway @entity2 disrupts interleukin-17 mediated host defense against XXXX @entity5 .

answer: @entity6


abstract: UNASSIGNED: Despite decreasing rates of invasive @entity4 caused by vaccine serotypes, the prevalence of invasive @entity10 in @entity9 @entity0 remains high. However, little is known about the mechanisms underlying the susceptibility of the @entity9 airway to @entity12 . In this study, we used a combined model of @entity3 airway @entity2 and @entity6 @entity7 to investigate the association between persistent @entity2 in the airway and antibacterial host defenses against @entity11 . When challenged with @entity11 , @entity3 @entity1 exhibited higher airway bacterial burdens, greater eosinophil infiltration, lower neutrophil infiltration, and more severe structural damage than non- @entity3 @entity1 . In sensitized @entity1 , @entity11 @entity5 elicited higher IL-4 but lower IFN-y, @entity8 and defensin-b2 expression than in control @entity1 . These results indicate that persistent @entity2 impaired airway host defense against @entity11 is associated with the insufficient @entity8 responses. To elicit @entity8 induced-anti-bacterial immune responses, @entity1 were intranasally immunized with @entity13 . Immunized @entity1 exhibited fewer bacterial colonies in the respiratory tract and less severe lung pathology than unimmunized @entity1 . @entity13 contributed to airway host defense enhancement and innate immune response promotion, which was associated with increased @entity15 , @entity14 and defensin-b2 expression. Administration of exogenous @entity8 (2 g/ @entity1 ) suppressed eosinophil-related immune responses. The results demonstrate @entity8 plays a key role in host defenses against @entity12 and suggest that exogenous @entity8 administration promotes the anti-becterial immune responses and attenuates the existed @entity2 .

title: Allergic airway XXXX disrupts interleukin-17 mediated host defense against @entity6 @entity5 .

answer: @entity2


abstract: UNASSIGNED: Despite decreasing rates of invasive @entity4 caused by vaccine serotypes, the prevalence of invasive @entity10 in @entity9 @entity0 remains high. However, little is known about the mechanisms underlying the susceptibility of the @entity9 airway to @entity12 . In this study, we used a combined model of @entity3 airway @entity2 and @entity6 @entity7 to investigate the association between persistent @entity2 in the airway and antibacterial host defenses against @entity11 . When challenged with @entity11 , @entity3 @entity1 exhibited higher airway bacterial burdens, greater eosinophil infiltration, lower neutrophil infiltration, and more severe structural damage than non- @entity3 @entity1 . In sensitized @entity1 , @entity11 @entity5 elicited higher IL-4 but lower IFN-y, @entity8 and defensin-b2 expression than in control @entity1 . These results indicate that persistent @entity2 impaired airway host defense against @entity11 is associated with the insufficient @entity8 responses. To elicit @entity8 induced-anti-bacterial immune responses, @entity1 were intranasally immunized with @entity13 . Immunized @entity1 exhibited fewer bacterial colonies in the respiratory tract and less severe lung pathology than unimmunized @entity1 . @entity13 contributed to airway host defense enhancement and innate immune response promotion, which was associated with increased @entity15 , @entity14 and defensin-b2 expression. Administration of exogenous @entity8 (2 g/ @entity1 ) suppressed eosinophil-related immune responses. The results demonstrate @entity8 plays a key role in host defenses against @entity12 and suggest that exogenous @entity8 administration promotes the anti-becterial immune responses and attenuates the existed @entity2 .

title: Allergic airway @entity2 disrupts interleukin-17 mediated host defense against @entity6 XXXX .

answer: @entity5


abstract: The present study was designed to investigate the in vitro and in vivo anti-inflammatory activity of @entity4 isolated from Millettia pachycarpa Benth. The seeds of M. pachycarpa Benth were extracted with @entity3 and subjected to chromatographic separation for the isolation of bioactive compounds. Their structures were elucidated by spectroscopic methods. The anti-inflammatory activity of the compounds was investigated by evaluating the inhibition ability of NO production, @entity7 activity and @entity7 protein expression induced by LPS-stimulated RAW264.7 macrophages in vitro and the carrageenan-induced hind paw @entity0 model in vivo. Molecular docking simulation was also employed to obtain the binding parameters in the binding pocket of @entity7 . Thirteen compounds (1-13) were isolated from Chinese herbal medicine M. pachycarpa Benth. Among them, @entity8 (6) and @entity9 (7) exhibited remarkable inhibitory rates of 66.5% and 57.7%, respectively, compared with that of 52.5% of @entity5 in LPS-induced macrophages cells. @entity8 (6) with low @entity2 (IC50 > 100  m) exhibited better inhibitory effects to positive control of 1400W on @entity7 activity at the concentration of 10  m. Western blot assay revealed that @entity8 (6) inhibited @entity7 protein expression in RAW264.7 cells and molecular docking simulation showed that @entity8 (6) fit well into the binding pocket of @entity7 . In the carrageenan-induced paw @entity0 model, our data revealed that the anti-inflammatory potential of @entity8 (6) at 10 mg/kg showed comparable inhibitory ability to @entity5 at 5 h while a higher concentration of @entity8 (6) at 50 mg/kg showed higher inhibitory activity than @entity5 , which was further confirmed by plasma levels of @entity6 . The overall results suggest that @entity8 (6) might be used as a potential therapeutic agent for @entity1 .

title: Millettia pachycarpa exhibits anti-inflammatory activity through the suppression of LPS-induced NO/ XXXX expression.

answer: @entity7


abstract: Acute @entity4 is one of the major causes of mortality worldwide. Reperfusion in a timely fashion is the most effective way to limit @entity7 size. However, reperfusion can itself prompt further @entity0 . This phenomenon is commonly known as @entity5 -reperfusion (IR) injury. Mitochondrial @entity10 dehydrogenase ( @entity12 ) is an enzyme metabolizing @entity8 and toxic @entity9 . Increasing evidence has revealed a cardioprotective role of @entity12 in @entity5 . Evidence from animal studies has shown that @entity12 diminishes acute @entity4 size, ameliorates @entity1 and prevents reperfusion @entity6 . The activity of @entity12 is severely compromised if it is encoded by the mutant @entity12 *2 gene, with an incidence of approximately 40% in Asian populations. Epidemiological surveys in the Asian population have depicted that @entity12 polymorphism is closely associated with higher prevalence of @entity4 and @entity3 . Therefore, targeting @entity12 may represent a promising avenue to protect against @entity11 . This review recapitulates the underlying mechanisms involved in the protective effect of @entity12 in @entity11 . Translational potential of @entity12 in the management of @entity2 is also discussed.

title: Mitochondrial @entity10 dehydrogenase in XXXX -reperfusion injury: from bench to bedside.

answer: @entity5


abstract: Acute @entity4 is one of the major causes of mortality worldwide. Reperfusion in a timely fashion is the most effective way to limit @entity7 size. However, reperfusion can itself prompt further @entity0 . This phenomenon is commonly known as @entity5 -reperfusion (IR) injury. Mitochondrial @entity10 dehydrogenase ( @entity12 ) is an enzyme metabolizing @entity8 and toxic @entity9 . Increasing evidence has revealed a cardioprotective role of @entity12 in @entity5 . Evidence from animal studies has shown that @entity12 diminishes acute @entity4 size, ameliorates @entity1 and prevents reperfusion @entity6 . The activity of @entity12 is severely compromised if it is encoded by the mutant @entity12 *2 gene, with an incidence of approximately 40% in Asian populations. Epidemiological surveys in the Asian population have depicted that @entity12 polymorphism is closely associated with higher prevalence of @entity4 and @entity3 . Therefore, targeting @entity12 may represent a promising avenue to protect against @entity11 . This review recapitulates the underlying mechanisms involved in the protective effect of @entity12 in @entity11 . Translational potential of @entity12 in the management of @entity2 is also discussed.

title: Mitochondrial XXXX dehydrogenase in @entity5 -reperfusion injury: from bench to bedside.

answer: @entity10


abstract: BACKGROUND/AIMS: To evaluate the incidence of intraoperative @entity2 in the ultrahigh-speed (UHS) 25-gauge vitrectomy system in elective vitreous-retina surgery cases. METHODS: A prospective series of 1676 eyes of 1306 consecutive @entity0 . All eyes underwent an UHS 25-gauge transconjunctival sutureless pars plana vitrectomy for elective cases such as @entity6 (586 cases), floaters (153), macular hole (385), vitreous @entity3 (119), dropped nucleus or intraocular lens (84) and @entity1 (82). @entity0 were followed up for a minimum of 6   months. RESULTS: There were 1409 eyes involved in this study. @entity2 were found in 25 eyes (1.8%) during surgery. The majority were detected in cases where @entity8 was induced during surgery (21 eyes; 2.8% of the @entity0 ), and in only four eyes (0.6%) with an already detached vitreous. In nine cases, @entity4 developed during the follow-up. @entity0 who showed intraoperative @entity2 were not in this group. Other complications during the follow-up included two cases of @entity1 (0.1%), two cases of @entity5 (0.1%), and 23 eyes with @entity7 without any further complications. CONCLUSIONS: UHS 25-gauge transconjunctival sutureless vitrectomy is a safe procedure for treatment of elective vitreous-retina cases. The risk of developing iatrogenic breaks seems to be correlated with adhesion of the posterior vitreous hyaloid. Other complications, such as @entity4 or @entity7 , were similar to previous reports. No correlation was found between iatrogenic retina breaks and other complications.

title: XXXX in ultrahigh-speed 25-gauge vitrectomy: a prospective study of elective cases.

answer: @entity2


abstract: BACKGROUND: We have established a standard procedure for Roux-en-Y (RY) reconstruction in laparoscopic total gastrectomy (LTG) using esophagojejunostomy by the overlap method (OL). We report on our RY reconstruction technique and special approaches, and evaluate the usefulness of our reconstruction method based on the surgical results of 100 @entity0 we have experienced to date. METHODS: We performed LTG in 100 @entity0 with @entity4 . After total gastrectomy using five ports, the resected stomach was extracted through a small laparotomy. Through that, we performed sacrifice of the jejunum, Y limb @entity2 , creation of the lifted jejunum. As the OL, a side-to-side @entity2 of the lifted jejunum to the esophageal stump was laparoscopically performed using a linear stapler in an isoperistaltic direction, and the entry hole was closed with full-thickness suturing. The lifted jejunum was fixed with suture to the duodenal stump at a location where the esophagojejunostomy site was made linear, and the duodenal stump was buried. The mesenteric gap was laparoscopically closed with suture. RESULTS: The median operative time in 100 @entity0 undergoing LTG was 385  min, the median @entity1 was 65  mL, and the median time required for the OL was 32  min. The mean hospitalization period was 10  days, and @entity3 included @entity5 requiring reoperation in one @entity0 ; other complications such as @entity8 in five @entity0 (5  %) were treated conservatively. No complication associated with @entity2 occurred. CONCLUSION: In RY reconstruction using the OL, there were no complications associated with the @entity2 site in 100 consecutive @entity0 , such as @entity6 or @entity7 , indicating that it is a very useful and safe reconstruction method.

title: Technique of Roux-en-Y reconstruction using overlap method after laparoscopic total gastrectomy for XXXX : 100 consecutively successful cases.

answer: @entity4


abstract: UNASSIGNED: The present study was designed to test the effects of @entity1 ( @entity2 ) exposure on the maturation of endocrine functioning and sexual behavior. Female @entity0 pups received either @entity2 (2.0mg/kg, i.p.) or saline twice daily between postnatal days 20-35. This period of exposure represents the time just prior to puberty as well as puberty onset. Approximately five weeks after the last injection of @entity2 or saline, female subjects were hormone-primed and tested during their first sexual experience. Subjects were given the choice to interact with a sexually active male or a sexually receptive female @entity0 (i.e., the partner-preference test). The partner-preference paradigm allows us to assess multiple aspects of female sexual behavior. @entity2 exposure during peri-adolescence delayed puberty and, when mated for the first time, affected sexual behavior (e.g., increased time spent with the male stimulus and decreased the likelihood of leaving after mounts) during the test of partner preference. When monitoring estrous cyclicity, female subjects treated with @entity2 during peri-adolescence frequently experienced irregular estrous cycles. The results of the present study suggest that chronic exposure to a therapeutic dose of @entity2 around the onset of puberty alters long-term endocrine functioning, but with hormone priming, increases sensitivity to sexual stimuli.

title: Exposure to XXXX during peri-adolescence affects endocrine functioning and sexual behavior in female Long-Evans @entity0 .

answer: @entity1


abstract: UNASSIGNED: The present study was designed to test the effects of @entity1 ( @entity2 ) exposure on the maturation of endocrine functioning and sexual behavior. Female @entity0 pups received either @entity2 (2.0mg/kg, i.p.) or saline twice daily between postnatal days 20-35. This period of exposure represents the time just prior to puberty as well as puberty onset. Approximately five weeks after the last injection of @entity2 or saline, female subjects were hormone-primed and tested during their first sexual experience. Subjects were given the choice to interact with a sexually active male or a sexually receptive female @entity0 (i.e., the partner-preference test). The partner-preference paradigm allows us to assess multiple aspects of female sexual behavior. @entity2 exposure during peri-adolescence delayed puberty and, when mated for the first time, affected sexual behavior (e.g., increased time spent with the male stimulus and decreased the likelihood of leaving after mounts) during the test of partner preference. When monitoring estrous cyclicity, female subjects treated with @entity2 during peri-adolescence frequently experienced irregular estrous cycles. The results of the present study suggest that chronic exposure to a therapeutic dose of @entity2 around the onset of puberty alters long-term endocrine functioning, but with hormone priming, increases sensitivity to sexual stimuli.

title: Exposure to @entity1 during peri-adolescence affects endocrine functioning and sexual behavior in female Long-Evans XXXX .

answer: @entity0


abstract: @entity1 is a worldwide problem in @entity0 and domestic animals. Interventions, including a combination of dietary management and exercise, have proven to be effective for inducing @entity3 in @entity0 . In companion animals, the role of exercise in the management of @entity1 has received relatively little attention. The aim of the present study was to investigate changes in the transcriptome of key energy metabolism genes in muscle and adipose tissues in response to diet-induced @entity3 alone, or combined with exercise in @entity2 . Overweight pet @entity2 were enrolled on a @entity3 programme, based on calorie restriction and physical training (FD group, n   =   5) or calorie restriction alone (DO group, n   =   7). mRNA expression of 12 genes and six microRNAs were investigated using quantitative real-time PCR (qPCR). In the FD group, @entity7 and @entity5 were expressed at lower levels in adipose tissue, whereas @entity8 and @entity9 were more highly expressed in muscle, when compared with the DO group. Comparing expression before and after the intervention, in the DO group, nine genes and three microRNAs showed significant altered expression in adipose tissue ( @entity6 , @entity10 and @entity7 ; P   <   0.001) and seven genes and two microRNAs were significantly downregulated (NRF2, @entity5 , @entity8 , @entity9 , PGC1a and mir-23; P   <   0.001) in muscle. Thus, calorie restriction causes regulation of several metabolic genes in both tissues. The mild exercise, incorporated into this study design, was sufficient to elicit transcriptional changes in adipose and muscle tissues, suggesting a positive effect on @entity4 metabolism. The study findings support inclusion of exercise in management of @entity2 @entity1 .

title: Physical training and XXXX in @entity2 lead to transcriptional changes in genes involved in the @entity4 -transport pathway in muscle and adipose tissues.

answer: @entity3


abstract: @entity1 is a worldwide problem in @entity0 and domestic animals. Interventions, including a combination of dietary management and exercise, have proven to be effective for inducing @entity3 in @entity0 . In companion animals, the role of exercise in the management of @entity1 has received relatively little attention. The aim of the present study was to investigate changes in the transcriptome of key energy metabolism genes in muscle and adipose tissues in response to diet-induced @entity3 alone, or combined with exercise in @entity2 . Overweight pet @entity2 were enrolled on a @entity3 programme, based on calorie restriction and physical training (FD group, n   =   5) or calorie restriction alone (DO group, n   =   7). mRNA expression of 12 genes and six microRNAs were investigated using quantitative real-time PCR (qPCR). In the FD group, @entity7 and @entity5 were expressed at lower levels in adipose tissue, whereas @entity8 and @entity9 were more highly expressed in muscle, when compared with the DO group. Comparing expression before and after the intervention, in the DO group, nine genes and three microRNAs showed significant altered expression in adipose tissue ( @entity6 , @entity10 and @entity7 ; P   <   0.001) and seven genes and two microRNAs were significantly downregulated (NRF2, @entity5 , @entity8 , @entity9 , PGC1a and mir-23; P   <   0.001) in muscle. Thus, calorie restriction causes regulation of several metabolic genes in both tissues. The mild exercise, incorporated into this study design, was sufficient to elicit transcriptional changes in adipose and muscle tissues, suggesting a positive effect on @entity4 metabolism. The study findings support inclusion of exercise in management of @entity2 @entity1 .

title: Physical training and @entity3 in @entity2 lead to transcriptional changes in genes involved in the XXXX -transport pathway in muscle and adipose tissues.

answer: @entity4


abstract: @entity1 is a worldwide problem in @entity0 and domestic animals. Interventions, including a combination of dietary management and exercise, have proven to be effective for inducing @entity3 in @entity0 . In companion animals, the role of exercise in the management of @entity1 has received relatively little attention. The aim of the present study was to investigate changes in the transcriptome of key energy metabolism genes in muscle and adipose tissues in response to diet-induced @entity3 alone, or combined with exercise in @entity2 . Overweight pet @entity2 were enrolled on a @entity3 programme, based on calorie restriction and physical training (FD group, n   =   5) or calorie restriction alone (DO group, n   =   7). mRNA expression of 12 genes and six microRNAs were investigated using quantitative real-time PCR (qPCR). In the FD group, @entity7 and @entity5 were expressed at lower levels in adipose tissue, whereas @entity8 and @entity9 were more highly expressed in muscle, when compared with the DO group. Comparing expression before and after the intervention, in the DO group, nine genes and three microRNAs showed significant altered expression in adipose tissue ( @entity6 , @entity10 and @entity7 ; P   <   0.001) and seven genes and two microRNAs were significantly downregulated (NRF2, @entity5 , @entity8 , @entity9 , PGC1a and mir-23; P   <   0.001) in muscle. Thus, calorie restriction causes regulation of several metabolic genes in both tissues. The mild exercise, incorporated into this study design, was sufficient to elicit transcriptional changes in adipose and muscle tissues, suggesting a positive effect on @entity4 metabolism. The study findings support inclusion of exercise in management of @entity2 @entity1 .

title: Physical training and @entity3 in XXXX lead to transcriptional changes in genes involved in the @entity4 -transport pathway in muscle and adipose tissues.

answer: @entity2


abstract: AIMS: Impact of @entity4 on cardiac structure has not been extensively investigated in large, multi-ethnic, community-based populations. We investigated the longitudinal impact of @entity4 on cardiac structure by cardiac magnetic resonance (CMR). METHODS AND RESULTS: 2351 @entity0 in the Multi-Ethnic Study of @entity5 (MESA) who underwent CMR at Exam 1 (2002) and Exam 5 (2011) were included. Primary outcomes were percentage change in LV mass (indexed to height) and LV mass-to-volume ratio (concentric LV remodelling). Multivariable linear regression was used to measure the association between outcomes and weight change. At median 9.4 years' follow-up, 639 individuals (27%) experienced >5% @entity4 (median 6.9   kg) and 511 (22%) had >5% weight gain (median 6.4   kg). A >5% weight gain was associated with the greatest increase in LV mass (+5.4% median) and LV mass-to-volume ratio (+12.2% median). Adjusting for medications, @entity3 / @entity1 (and change in these risk factors), age, race and other risk factors, every 5% @entity4 was associated with a 1.3% decrease in height-indexed LV mass and 1.3% decrease in LV mass-to-volume ratio (p<0.0001). There was no effect modification/confounding by age, race, gender or baseline BMI. Change in LV mass-to-volume ratio was roughly linear, specifically for modest degrees of @entity4 (-10% to +10%). Change in LV mass was linear with @entity4 , suggesting no threshold of @entity4 is needed for LV mass regression. CONCLUSIONS: In a large multi-ethnic population, @entity4 is associated with beneficial effects on cardiac structure, independent of age, race, gender, BMI and @entity2 -related cardiometabolic risk. There is no threshold of @entity4 required to produce these effects.

title: Weight loss and progressive left ventricular remodelling: The Multi-Ethnic Study of XXXX (MESA).

answer: @entity5