abstract: OBJECTIVE: To summarize the effect of antipsychotics for preventing @entity1 . DESIGN: We conducted a literature search using Medline, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and clinicaltrials.gov. We included randomized controlled trials of adults undergoing surgery who were given antipsychotics to prevent @entity1 . Quality was assessed via the Cochrane risk of bias tool. Random-effects meta-analysis and meta-regression were conducted. Q-statistics and I(2) were used for assessment of heterogeneity. The main outcome was @entity2 incidence using validated definitions. RESULTS: A total of 1710 subjects were included, with a mean age ranging from 60.7 to 86.4   years. Antipsychotics reduced the incidence of @entity1 with the global effect-size estimate (weighted odds ratio) using the random effects model of 0.44 (95% confidence interval: 0.28-0.70; N   =   6; Q-value: 16, p-value 0.0005; I(2)    =   69%). Significant heterogeneity existed with the pooled global effect of @entity2 incidence; however, meta-regression allowed us to test both treatment-level and @entity0 -level explanations for significant between-study variance. Baseline risk for @entity2 was found to be a significant contributor to study heterogeneity, and meta-regression suggested that antipsychotic type and dosage were two of the several treatment-level factors that also may have led to heterogeneity. Our analysis implied the presence of a breakeven baseline level of @entity2 risk below which preventive treatment with antipsychotics might prove ineffective. CONCLUSIONS: Within the limits of few randomized controlled trials, antipsychotics appeared to reduce the incidence of @entity1 in several surgical settings, predominantly orthopedic and for those at higher risk for @entity2 . Copyright    2015 John Wiley _ Sons, Ltd.

title: Do antipsychotics prevent XXXX ? A systematic review and meta-analysis.

answer: @entity1


abstract: BACKGROUND: One of the most important functions of the @entity3 ( @entity3 ) is to assess @entity0 status. Only one, the pediatric early warning score (PEWS), has been designed for @entity3 with acceptable validity, but it has never been validated in Thailand. The objective of this study was to validate PEWS in predicting hospitalization in @entity0 visiting the @entity3 . METHODS: During the initial phase, two triage nurses performed blind scoring (in order to determine inter-rater reliability using kappa statistics) for the first 30 @entity0 who presented to the @entity3 at Ramathibodi Hospital between March and May 2014 and who were aged <15   years. The second phase then consisted of validation and involved 1136 @entity0 . @entity0 who presented with @entity1 , @entity2 , dental and surgical concerns were excluded. Validity of the scoring system in predicting admission was assessed using area under the receiver operating characteristics (ROC) curve (AUC), sensitivity, and specificity, positive predictive value ( @entity4 ) and negative predictive value (NPV). RESULTS: Phase I demonstrated good inter-rater reliability (kappa = 0.75). In phase II, of the total group of 1136 @entity0 , 168 @entity0 (14.8%) were admitted: 162 to the general ward and six to the intensive care unit (ICU) during the study period. AUC for predicting overall, ICU, and general ward admission were 0.73 (95%CI: 0.68-0.77), 0.98 (95%CI: 0.96-1) and 0.71 (95%CI: 0.66-0.75), respectively. The sensitivity and specificity in predicting overall admission with a cut-off of PEWS >= 1 was 78% and 60%, respectively ( @entity4 , 28%; NPV, 95%). Sensitivity and specificity in predicting ICU admission with the cut-off PEWS >= 3 was 100% and 91%, respectively ( @entity4 , 5%; NPV, 100%). Using the cut-off PEWS >= 1, sensitivity and specificity in predicting ward admission were 77% and 59%, respectively ( @entity4 , 24%; NPV, 94%). CONCLUSION: PEWS can be helpful in assessing @entity0 status in pediatric @entity3 with acceptable validity and can serve as a potentially excellent screening tool for prediction of ICU admission.

title: Validation of pediatric early warning score in pediatric XXXX .

answer: @entity3


abstract: UNASSIGNED: Irradiation in conjunction with gene therapy is considered for efficient @entity1 treatment. Mesenchymal stem cells (MSCs), due to their irradiation-promotable @entity1 tropism, are ideal delivery vehicles for gene therapy. In this study, we investigated whether treatment with radiation and interleukin (IL)-12-expressing MSCs (MSCs/IL-12) exerts improved antitumor effects on @entity2 metastatic @entity4 . HCa-I and Hepa 1-6 cells were utilized to generate heterotopic @entity2 @entity4 models. Tumor-bearing @entity2 were treated with irradiation or MSCs/IL-12 alone, or a combination. @entity5 ( @entity5 / @entity5 ) expression was assessed in irradiated @entity4 tissues to confirm a chemotactic effect. Combination treatment strategies were established and their therapeutic efficacies were evaluated by monitoring @entity1 growth, @entity0 and survival rate. IL-12 expression was assessed and the apoptotic activity and immunological alterations in the @entity1 microenvironment were examined. @entity5 / @entity5 expression and localization of MSCs/IL-12 increased in the irradiated @entity2 @entity4 cells. The antitumor effects, including suppression of pulmonary @entity0 and survival rate improvements, were increased by the combination treatment with irradiation and MSCs/IL-12. IL-12 expression was increased in @entity1 cells, causing proliferation of cluster of differentiation 8(+) T-lymphocytes and natural killer cells. The apoptotic activity increased, indicating that the @entity3 of immune cells was involved in the antitumor effect of the combined treatment. Treatment with irradiation and MSCs/IL-12 showed effectiveness in treating @entity2 metastatic @entity4 . IL-12-induced proliferation of immune cells played an important role in apoptosis of @entity1 cells. Our results suggest that treatment with irradiation and MSCs/IL-12 may be a useful strategy for enhancing antitumor activity in metastatic @entity4 .

title: Irradiation-induced localization of IL-12-expressing mesenchymal stem cells to enhance the curative effect in @entity2 metastatic XXXX .

answer: @entity4


abstract: UNASSIGNED: Irradiation in conjunction with gene therapy is considered for efficient @entity1 treatment. Mesenchymal stem cells (MSCs), due to their irradiation-promotable @entity1 tropism, are ideal delivery vehicles for gene therapy. In this study, we investigated whether treatment with radiation and interleukin (IL)-12-expressing MSCs (MSCs/IL-12) exerts improved antitumor effects on @entity2 metastatic @entity4 . HCa-I and Hepa 1-6 cells were utilized to generate heterotopic @entity2 @entity4 models. Tumor-bearing @entity2 were treated with irradiation or MSCs/IL-12 alone, or a combination. @entity5 ( @entity5 / @entity5 ) expression was assessed in irradiated @entity4 tissues to confirm a chemotactic effect. Combination treatment strategies were established and their therapeutic efficacies were evaluated by monitoring @entity1 growth, @entity0 and survival rate. IL-12 expression was assessed and the apoptotic activity and immunological alterations in the @entity1 microenvironment were examined. @entity5 / @entity5 expression and localization of MSCs/IL-12 increased in the irradiated @entity2 @entity4 cells. The antitumor effects, including suppression of pulmonary @entity0 and survival rate improvements, were increased by the combination treatment with irradiation and MSCs/IL-12. IL-12 expression was increased in @entity1 cells, causing proliferation of cluster of differentiation 8(+) T-lymphocytes and natural killer cells. The apoptotic activity increased, indicating that the @entity3 of immune cells was involved in the antitumor effect of the combined treatment. Treatment with irradiation and MSCs/IL-12 showed effectiveness in treating @entity2 metastatic @entity4 . IL-12-induced proliferation of immune cells played an important role in apoptosis of @entity1 cells. Our results suggest that treatment with irradiation and MSCs/IL-12 may be a useful strategy for enhancing antitumor activity in metastatic @entity4 .

title: Irradiation-induced localization of IL-12-expressing mesenchymal stem cells to enhance the curative effect in XXXX metastatic @entity4 .

answer: @entity2


abstract: OBJECTIVES: To investigate the efficacy and safety of percutaneous @entity2 (PTBD) for the treatment of bilateral pulmonary artery banding (bil-PAB) site @entity6 . Background: Although bil-PAB is an alternative initial treatment for high-risk neonates with @entity7 ( @entity7 ) or critical @entity4 (cAS), those @entity0 often suffer from desaturation because of progressive @entity6 of the bil-PAB sites during the interstage period. METHODS: We retrospectively evaluated the efficacy and safety of 11 consecutive PTBD procedures performed between 2006 and 2012 to treat bil-PAB site @entity6 in four high-risk @entity0 (three females) with @entity7 or cAS. RESULTS: PTBD was repeated twice in two @entity0 and three times in one @entity0 over intervals. The mean @entity5 ( @entity5 ) and @entity5 -to-band circumference (BC) ratio were 3.1        0.5 mm and 0.31        0.06, respectively. After the procedures, the mean minimum lumen diameter was dilated significantly from 1.1        0.1 mm to 1.7        0.3 mm (P   <   0.01), and the mean peripheral @entity1 saturation increased significantly from 75        8% to 85        4% (P   <   0.01). All @entity0 reached the next stage operation involving the Norwood _ bidirectional Glenn or Ross procedure, after growth. No complications such as band @entity3 occurred. CONCLUSIONS: For progressive @entity6 of bil-PAB sites, PTBD using a balloon size that did not exceed the BC ( @entity5 around 30% of the BC) was an effective and safe procedure.    2015 Wiley Periodicals, Inc.

title: Efficacy and safety of percutaneous @entity2 to prevent progression of banding site XXXX after bilateral pulmonary artery banding.

answer: @entity6


abstract: OBJECTIVES: To investigate the efficacy and safety of percutaneous @entity2 (PTBD) for the treatment of bilateral pulmonary artery banding (bil-PAB) site @entity6 . Background: Although bil-PAB is an alternative initial treatment for high-risk neonates with @entity7 ( @entity7 ) or critical @entity4 (cAS), those @entity0 often suffer from desaturation because of progressive @entity6 of the bil-PAB sites during the interstage period. METHODS: We retrospectively evaluated the efficacy and safety of 11 consecutive PTBD procedures performed between 2006 and 2012 to treat bil-PAB site @entity6 in four high-risk @entity0 (three females) with @entity7 or cAS. RESULTS: PTBD was repeated twice in two @entity0 and three times in one @entity0 over intervals. The mean @entity5 ( @entity5 ) and @entity5 -to-band circumference (BC) ratio were 3.1        0.5 mm and 0.31        0.06, respectively. After the procedures, the mean minimum lumen diameter was dilated significantly from 1.1        0.1 mm to 1.7        0.3 mm (P   <   0.01), and the mean peripheral @entity1 saturation increased significantly from 75        8% to 85        4% (P   <   0.01). All @entity0 reached the next stage operation involving the Norwood _ bidirectional Glenn or Ross procedure, after growth. No complications such as band @entity3 occurred. CONCLUSIONS: For progressive @entity6 of bil-PAB sites, PTBD using a balloon size that did not exceed the BC ( @entity5 around 30% of the BC) was an effective and safe procedure.    2015 Wiley Periodicals, Inc.

title: Efficacy and safety of percutaneous XXXX to prevent progression of banding site @entity6 after bilateral pulmonary artery banding.

answer: @entity2


abstract: In a large multicentre sample of cognitively normal subjects, as a function of age, gender and @entity2 genotype, we studied the frequency of abnormal cerebrospinal fluid levels of @entity1 biomarkers including: total tau, phosphorylated tau and amyloid-b1-42. Fifteen cohorts from 12 different centres with either enzyme-linked immunosorbent assays or Luminex   measurements were selected for this study. Each centre sent nine new cerebrospinal fluid aliquots that were used to measure total tau, phosphorylated tau and amyloid-b1-42 in the Gothenburg laboratory. Seven centres showed a high correlation with the new Gothenburg measurements; therefore, 10 cohorts from these centres are included in the analyses here (1233 healthy control subjects, 40-84 years old). Amyloid-b amyloid status (negative or positive) and @entity0 status (negative or positive) was established based on the pathological cerebrospinal fluid @entity1 cut-off values for cerebrospinal fluid amyloid-b1-42 and total tau, respectively. While gender did not affect these biomarker values, @entity2 genotype modified the age-associated changes in cerebrospinal fluid biomarkers such that @entity2 carriers showed stronger age-related changes in cerebrospinal fluid phosphorylated tau, total tau and amyloid-b1-42 values and @entity2 carriers showed the opposite effect. At 40 years of age, 76% of the subjects were classified as amyloid negative, @entity0 negative and their frequency decreased to 32% at 85 years. The amyloid-positive @entity0 -negative group remained stable. The amyloid-negative @entity0 -positive group frequency increased slowly from 1% at 44 years to 16% at 85 years, but its frequency was not affected by @entity2 genotype. The amyloid-positive @entity0 -positive frequency increased from 1% at 53 years to 28% at 85 years. Abnormally low cerebrospinal fluid amyloid-b1-42 levels were already frequent in midlife and @entity2 genotype strongly affects the levels of cerebrospinal fluid amyloid-b1-42, phosphorylated tau and total tau across the lifespan without influencing the frequency of subjects with suspected non-amyloid pathology.

title: XXXX cerebrospinal fluid biomarker in cognitively normal subjects.

answer: @entity1


abstract: BACKGROUND: The use of femoral @entity5 (FNB) combined with sciatic @entity5 (SNB) after total knee arthroplasty (TKA) has recently become controversial. @entity6 ( @entity6 ) has been reported to be effective for postoperative @entity1 control. We aimed to assess whether @entity6 with continuous FNB is as effective as SNB combined with continuous FNB. METHODS: This was a prospective, randomized, single-center, observer-blinded, parallel group comparison trial of 34 American Society of Anesthesiologists (ASA) physical status 1-3 @entity0 who underwent TKA and fulfilled the inclusion and exclusion criteria. @entity0 were randomized into two groups: a periarticular @entity6 and FNB group (group L, n   =   17), and an SNB and FNB group (group S, n   =   17). In both groups, @entity0 received FNB with 20  mL of 0.375  % @entity7 , and 5  mL  h(-1) of 0.2  % @entity7 after surgery. In group L, @entity0 received 100-ml injections of 0.2  % @entity7 and 0.5  mg @entity8 to the surgical region. In group S, @entity0 received SNB with 20  ml of 0.375  % @entity7 . After TKA, Numeric Rating Scale (NRS) scores for the first 24  h post-operation were compared via repeated-measures analysis of variance (ANOVA) as the primary outcome. Other outcome measures included NRS score changes within groups, area under the curve for the NRS scores, total analgesic dose, change in knee flexion and extension, @entity1 control satisfaction, @entity3 and @entity4 , and hospital stay duration. RESULTS: NRS score changes were greater in group L than in group S (P   <   0.01, ANOVA) and greater in group L than in group S at three postoperative time points: 3  h (P   <   0.01), 6  h (P   <   0.01), and 12  h (P   =   0.013; Mann-Whitney U test). Changes in the mean NRS score were observed in each group (P   <   0.01, Friedman test). No significant differences were detected in the other outcome measures (Mann-Whitney U, Wilcoxon signed-rank, and chi-squared tests). CONCLUSIONS: Sciatic @entity5 with femoral @entity5 is superior to local anesthetic infiltration with femoral @entity5 for @entity2 control within 3-12  h of total knee arthroplasty. TRIAL REGISTRATION: UMIN-CTR ID: 000013364 R: 000015591.

title: Femoral nerve block-sciatic nerve block vs. femoral XXXX -local infiltration analgesia for total knee arthroplasty: a randomized controlled trial.

answer: @entity5


abstract: Aim. To study the efficacy and safety of subantimicrobial dose (SD) @entity4 (50   mg/d) in @entity0 with active and moderate-to-severe @entity3 ( @entity3 ). Methods. Thirteen @entity0 with active and moderate-to-severe @entity3 received once daily oral @entity4 (50   mg/d) for 12   wk. Treatment response at 24   wk was used as the primary outcome, measured by a composite of improvement in @entity2 ( @entity2 ), @entity1 , motility, soft tissue swelling, @entity5 , and eyelid aperture. Secondary outcome was the change of quality of life score (QoL, including visual functioning subscale and appearance subscale). Adverse events were also recorded. Results. Overall improvement was noted in eight out of 13 @entity0 (61.5%, 95% CI 31.6%-86.1%). Both @entity2 and soft tissue swelling significantly ameliorated in eight @entity0 at 24   wk. Five @entity0 (38.5%) had improvement in ocular motility of >= 8 degrees. Eyelid aperture (46.2%) also decreased remarkably. For QoL, a significant improvement in appearance subscale (P = 0.008) was noted during the study, whereas no difference was observed in visual functioning subscale (P = 0.21). Two @entity0 reported mild stomachache at 12   wk. Conclusions. SD @entity4 appears to be effective and safe for the treatment of active and moderate-to-severe @entity3 . It might serve as a new promising therapeutic strategy for @entity3 . This trial is registered with NCT01727973.

title: Efficacy of Subantimicrobial Dose XXXX for Moderate-to-Severe and Active Graves' Orbitopathy.

answer: @entity4


abstract: Objective Approximately 5-10% of preschool age @entity0 are considered developmentally disabled. Brain Magnetic Resonance Imaging (MRI) plays a key role in the diagnostic evaluation in these @entity0 . Many congenital or acquired @entity1 are revealed with MRIs. Although the majority of these abnormalities are sporadic but @entity0 with @entity11 or @entity11 have sex-linked inheritance. We are going to present the first case in Iran from Ahvaz city, which was presented with @entity2 associated with @entity3 and finally diagnosed as @entity11 , because @entity15 cases especially for continuous or generalized form is rare. A 4.5-year-old developmentally delayed @entity0 was admitted for generalized tonic clonic @entity6 attack of 1 hr, upward gaze, @entity9 , and @entity5 ( @entity2 ) in the @entity0 neurology ward. She had a history of recurrent @entity6 that @entity6 since she was 12 months of age and had frequent admissions for having recurrent @entity6 attacks. She was the only @entity0 of consanguineous parents with negative family history of any neurologic problems. She was a product of uneventful term pregnancy, vaginal delivery with a low Apgar score at birth who was admitted for six days in the neonatal ward for @entity10 and @entity7 . At 4.5 years of age, she had HC: 45cm (<3%) Length: 102 cm (25-75%), and BW: 18kg (75%). She was able to sit, walk with support, speak a few words, and communicate with others. A physical exam was unremarkable. Lab data including CBC, blood biochemical, and urinalysis results were all within normal limits, but the electroencephalography (EEG) revealed generalized poly spike-wave discharges. A brain MRI showed @entity14 , generalized @entity15 , and @entity12 . She was discharged home with oral @entity8 and regular outpatient follow-ups. In the diagnostic evaluation of developmentally delayed and @entity4 @entity0 , a brain MRI is strongly recommended for accurate diagnosis of anomalies such as @entity13 ( @entity15 ) and others, because appropriate therapeutic management, prognosis, prevention, and genetic counseling for prenatal diagnosis are dependent on definite diagnosis of the proband case.

title: Double Cortex Syndrome ( XXXX ): A Case Report.

answer: @entity11


abstract: AIM: To update our experiences with minimally invasive McKeown esophagectomy for @entity4 . METHODS: We retrospectively reviewed the medical records of 445 consecutive @entity0 who underwent minimally invasive McKeown esophagectomy between January 2009 and July 2015 at the @entity1 Hospital of Chinese Academy of Medical Sciences and used 103 @entity0 who underwent open McKeown esophagectomy in the same period as controls. Among 375 @entity0 who underwent total minimally invasive McKeown esophagectomy, 180 in the early period were chosen for the study of learning curve of total minimally invasive McKeown esophagectomy. These 180 minimally invasive McKeown esophagectomies performed by five surgeons were divided into three groups according to time sequence as group 1 (n = 60), group 2 (n = 60) and group 3 (n = 60). RESULTS: @entity0 who underwent total minimally invasive McKeown esophagectomy had significantly less intraoperative @entity2 than @entity0 who underwent hybrid minimally invasive McKeown esophagectomy or open McKeown esophagectomy (100 mL vs 300 mL vs 200 mL, P = 0.001). However, there were no significant differences in operation time, number of harvested lymph nodes, or postoperative morbidity including incidence of @entity3 and @entity5 between total minimally invasive McKeown esophagectomy, hybrid minimally invasive McKeown esophagectomy and open McKeown esophagectomy groups. There were no significant differences in 5-year survival between these three groups (60.5% vs 47.9% vs 35.6%, P = 0.735). @entity0 in group 1 had significantly longer duration of operation than those in groups 2 and 3. There were no significant differences in intraoperative @entity2 , number of harvested lymph nodes, or postoperative morbidity including incidence of @entity3 and @entity5 between groups 1, 2 and 3. CONCLUSION: Total minimally invasive McKeown esophagectomy was associated with @entity2 and comparable short term and long term survival compared with hybrid minimally invasive McKeown esophagectomy or open Mckeown esophagectomy. At least 12 cases are needed to master total minimally invasive McKeown esophagectomy in a high volume center.

title: Updated experiences with minimally invasive McKeown esophagectomy for XXXX .

answer: @entity4


abstract: AIM: To compare the outcomes between the Stretta procedure and laparoscopic toupet fundoplication (LTF) in @entity0 with @entity2 ( @entity2 )-related extra-esophageal symptoms. METHODS: From January 2011 to February 2012, a total of 98 @entity0 diagnosed with @entity2 -related extra-esophageal symptoms who met the inclusion criteria were enrolled in this study. All @entity0 who either underwent the Stretta procedure or LTF treatment have now completed the 3-year follow-up. Primary outcome measures, including frequency and severity of extra-esophageal symptoms, proton pump inhibitor (PPI) use, satisfaction, and @entity1 , were assessed. The results of the Stretta procedure and LTF therapy were analyzed and compared. RESULTS: There were 47 @entity0 in the Stretta group and 51 @entity0 in the LTF group. Ninety @entity0 were available at the 3-year follow-up. The total of the frequency and severity scores for every symptom improved in both groups (P < 0.05). Improvement in symptom scores of cough, sputum, and wheezing did not achieve statistical significance between the two groups (P > 0.05). However, the score for globus hysterics was different between the Stretta group and the LTF group (4.9    2.24 vs 3.2    2.63, P < 0.05). After the Stretta procedure and LTF treatment, 29 and 33 @entity0 in each group achieved PPI therapy independence (61.7% vs 64.7%, P = 0.835). The @entity0 in the LTF group were more satisfied with their quality of life than those in the Stretta procedure group (P < 0.05). Most complications resolved without intervention within two weeks; however, two @entity0 in the LTF group still suffered from severe @entity3 2 wk after the operation, and it improved after bougie dilation treatment in both @entity0 . CONCLUSION: The Stretta procedure and LTF were both safe and effective for the control of @entity2 -related extra-esophageal symptoms and the reduction of PPI use.

title: Comparison of Stretta procedure and toupet fundoplication for XXXX -related extra-esophageal symptoms.

answer: @entity2


abstract: BACKGROUND: The prognostic role of swallowing-related, pretreatment subjective and objective findings has not been investigated in detail. The authors evaluated the association between pretreatment MD Anderson @entity3 Inventory (MDADI) or videofluorographic swallowing study (VFSS) results and standard outcomes, including early recurrence and survival, in @entity0 with treatment-na  ve @entity2 ( @entity2 ). METHODS: @entity0 with @entity2 (n   =   191) who received treatment at the authors' institution and were examined by self-administered MDADI questionnaires and VFSS were prospectively enrolled. MDADI and VFSS findings were analyzed in correlation with clinicopathologic variables, and factors that predicted 2-year disease-free survival (DFS) and overall survival (OS) were identified using a Cox proportional-hazards regression model. RESULTS: The 2-year OS and DFS rates were 80.1% and 77.5%, respectively. @entity1 ( @entity1 ) and lymph node (N) classifications, overall TNM stage, sex, @entity1 site, and educational level were significantly associated with specific MDADI subdomains, whereas Karnofsky performance score was significantly associated with all MDADI subdomains. After controlling for clinical factors, total scores, global assessment scores, and emotional and physical MDADI subscores were significantly predictive of 2-year OS and DFS (P   <   .05 for each). VFSS findings were not significantly associated with survival (P   >   .05). CONCLUSIONS: The current results provide evidence of the prognostic role of the MDADI in predicting early survival outcomes in @entity0 with @entity2 . The MDADI may be a practical and noninvasive method for the identification of @entity0 at risk who would benefit from close follow-up.

title: Pretreatment XXXX Inventory and videofluorographic swallowing study as prognostic indicators of early survival outcomes in head and neck cancer.

answer: @entity3


abstract: UNASSIGNED: The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin I-converting enzyme gene ( @entity1 ) has been extensively studied as a predisposing factor for idiopathic recurrent @entity2 (IRSA). A case-control study including 149 @entity0 with >= 3 spontaneous @entity3 and 149 controls was performed to test the association of @entity1 I/D polymorphism with IRSA. A systematic review was conducted of previous case-control studies, with strict selection criteria for meta-analyses. We also aimed to evaluate the potential differences in summary estimates between studies defining IRSA as >= 2 and >= 3 spontaneous @entity3 . Genotyping was performed by PCR, and systematic review conducted using PubMed and Scopus. There was no association of the polymorphism with IRSA in Slovenian @entity0 . Sixteen case-control studies, showing substantial differences regarding IRSA definition and selection criteria for @entity0 were identified. Meta-analysis was performed and included four studies defining IRSA as >= 2 spontaneous @entity3 and the current study, which defined IRSA as >= 3 spontaneous @entity3 . Based on random effects model, meta-analysis conducted on 1192 @entity0 and 736 controls showed no association with IRSA under dominant(DD+IDvsII) and recessive(DDvsID+II) genetic models. Well-designed studies are needed to evaluate the role of @entity1 I/D polymorphism in IRSA defined as >= 3 spontaneous @entity3 .

title: Insertion/deletion polymorphism in intron 16 of XXXX gene in idiopathic recurrent @entity2 : case-control study, systematic review and meta-analysis.

answer: @entity1


abstract: UNASSIGNED: The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin I-converting enzyme gene ( @entity1 ) has been extensively studied as a predisposing factor for idiopathic recurrent @entity2 (IRSA). A case-control study including 149 @entity0 with >= 3 spontaneous @entity3 and 149 controls was performed to test the association of @entity1 I/D polymorphism with IRSA. A systematic review was conducted of previous case-control studies, with strict selection criteria for meta-analyses. We also aimed to evaluate the potential differences in summary estimates between studies defining IRSA as >= 2 and >= 3 spontaneous @entity3 . Genotyping was performed by PCR, and systematic review conducted using PubMed and Scopus. There was no association of the polymorphism with IRSA in Slovenian @entity0 . Sixteen case-control studies, showing substantial differences regarding IRSA definition and selection criteria for @entity0 were identified. Meta-analysis was performed and included four studies defining IRSA as >= 2 spontaneous @entity3 and the current study, which defined IRSA as >= 3 spontaneous @entity3 . Based on random effects model, meta-analysis conducted on 1192 @entity0 and 736 controls showed no association with IRSA under dominant(DD+IDvsII) and recessive(DDvsID+II) genetic models. Well-designed studies are needed to evaluate the role of @entity1 I/D polymorphism in IRSA defined as >= 3 spontaneous @entity3 .

title: Insertion/deletion polymorphism in intron 16 of @entity1 gene in idiopathic recurrent XXXX : case-control study, systematic review and meta-analysis.

answer: @entity2


abstract: OBJECTIVE: It has been shown that Mesenchymal stem cells (MSCs) could prevent or alleviate @entity3 ( @entity3 ) when transplanted into lung; however, the mechanisms involved remains elusive. The study aimed to investigate the effect of MSCs in repairing alveolar fluid clearance (AFC) of @entity2 ( @entity2 ) cells through paracrine factors. MATERIALS AND METHODS: @entity6 ( @entity6 ) concentration in the supernatant of MSC culture medium was measured, and MSCs in lung after intravenous administration was traced. Next, MSCs transfected with or without @entity6 SiRNA were injected intravenously into LPS-induced @entity3 @entity1 . Histological change and wet/dry ratio were determined. @entity2 cells were co-cultured with MSCs under different experimental situations to analyze the variation of @entity7 subunits of @entity5 - @entity4 -ATPase in @entity2 cells. RESULTS: LPS-induced @entity3 was characterized by the typical inflammatory infiltrates, interalveolar septal thickening and increased wet/dry ratio. MSC administration significantly reduced the injury, while MSCs with @entity6 knockdown did no show the same effect. In vitro study also confirmed that expressions of @entity7 subunit were up-regulated as impaired @entity2 cells co-cultured with MSCs. Furthermore, expression of a1 subunit was down-regulated, while b1 subunit showed no apparent change as @entity2 cells were co-cultured with MSCs that were transfected with @entity6 siRNA. CONCLUSIONS: AFC was @entity0 insult. MSCs-derived @entity6 reduced the impaired AFC through up-regulated a1 subunit but not b1 subunit, which might provide a novel therapeutic strategy for @entity3 .

title: Mesenchymal stem cells ameliorate LPS-induced XXXX through @entity6 promoting alveolar fluid clearance of alveolar type II cells.

answer: @entity3


abstract: OBJECTIVE: It has been shown that Mesenchymal stem cells (MSCs) could prevent or alleviate @entity3 ( @entity3 ) when transplanted into lung; however, the mechanisms involved remains elusive. The study aimed to investigate the effect of MSCs in repairing alveolar fluid clearance (AFC) of @entity2 ( @entity2 ) cells through paracrine factors. MATERIALS AND METHODS: @entity6 ( @entity6 ) concentration in the supernatant of MSC culture medium was measured, and MSCs in lung after intravenous administration was traced. Next, MSCs transfected with or without @entity6 SiRNA were injected intravenously into LPS-induced @entity3 @entity1 . Histological change and wet/dry ratio were determined. @entity2 cells were co-cultured with MSCs under different experimental situations to analyze the variation of @entity7 subunits of @entity5 - @entity4 -ATPase in @entity2 cells. RESULTS: LPS-induced @entity3 was characterized by the typical inflammatory infiltrates, interalveolar septal thickening and increased wet/dry ratio. MSC administration significantly reduced the injury, while MSCs with @entity6 knockdown did no show the same effect. In vitro study also confirmed that expressions of @entity7 subunit were up-regulated as impaired @entity2 cells co-cultured with MSCs. Furthermore, expression of a1 subunit was down-regulated, while b1 subunit showed no apparent change as @entity2 cells were co-cultured with MSCs that were transfected with @entity6 siRNA. CONCLUSIONS: AFC was @entity0 insult. MSCs-derived @entity6 reduced the impaired AFC through up-regulated a1 subunit but not b1 subunit, which might provide a novel therapeutic strategy for @entity3 .

title: Mesenchymal stem cells ameliorate LPS-induced @entity3 through XXXX promoting alveolar fluid clearance of alveolar type II cells.

answer: @entity6


abstract: OBJECTIVE: General anesthesia in @entity1 @entity0 is both challenging and demanding. With the rates of @entity1 in the general population increasing, more @entity0 undergo bariatric surgery. The aim of this study was to compare the performance, effectiveness and recovery from anesthesia of @entity5 and @entity3 in combination with @entity4 , with and without bispectral index (BIS) monitoring in super @entity1 @entity0 undergoing bariatric surgery. @entity0 AND METHODS: In this prospective, double-blind, randomized, controlled study a total of 100 super @entity1 @entity0 (body mass index, BMI > 50 kg/m2) undergoing bariatric surgery were randomly allocated in four groups: a @entity5 group (n = 25), a @entity5 with BIS monitoring group (n = 25), a @entity3 group (n=25) and a @entity3 with BIS monitoring group (n=25). Hemodynamic parameters, depth of anesthesia, recovery from anesthesia and @entity2 were recorded. RESULTS: The mean age of @entity0 was 37.7    9.2 years and the median BMI was 57.86    9.33. There were no statistically significant differences between the four groups with respect to @entity0 characteristics, comorbidities and duration of surgery. The intraoperatively mean arterial pressure was significantly higher in both @entity3 groups. No significant difference was observed between the four groups in respect to heart rate changes during anesthesia. Although the time to eye-opening and extubation was significantly shorter in both @entity3 groups, recovery from anesthesia, assessed with the Aldrete, Chung and White recovery scores, was significantly faster in @entity5 groups. No significant difference was observed in @entity2 between the four groups. CONCLUSIONS: Although both @entity3 and @entity5 provide adequate general anesthesia, @entity5 may be preferable in super @entity1 @entity0 because of superior hemodynamic stability and faster recovery from anesthesia.

title: Anesthesia management for the super @entity1 : is XXXX superior to @entity3 as a sole anesthetic agent? A double-blind randomized controlled trial.

answer: @entity5


abstract: OBJECTIVE: General anesthesia in @entity1 @entity0 is both challenging and demanding. With the rates of @entity1 in the general population increasing, more @entity0 undergo bariatric surgery. The aim of this study was to compare the performance, effectiveness and recovery from anesthesia of @entity5 and @entity3 in combination with @entity4 , with and without bispectral index (BIS) monitoring in super @entity1 @entity0 undergoing bariatric surgery. @entity0 AND METHODS: In this prospective, double-blind, randomized, controlled study a total of 100 super @entity1 @entity0 (body mass index, BMI > 50 kg/m2) undergoing bariatric surgery were randomly allocated in four groups: a @entity5 group (n = 25), a @entity5 with BIS monitoring group (n = 25), a @entity3 group (n=25) and a @entity3 with BIS monitoring group (n=25). Hemodynamic parameters, depth of anesthesia, recovery from anesthesia and @entity2 were recorded. RESULTS: The mean age of @entity0 was 37.7    9.2 years and the median BMI was 57.86    9.33. There were no statistically significant differences between the four groups with respect to @entity0 characteristics, comorbidities and duration of surgery. The intraoperatively mean arterial pressure was significantly higher in both @entity3 groups. No significant difference was observed between the four groups in respect to heart rate changes during anesthesia. Although the time to eye-opening and extubation was significantly shorter in both @entity3 groups, recovery from anesthesia, assessed with the Aldrete, Chung and White recovery scores, was significantly faster in @entity5 groups. No significant difference was observed in @entity2 between the four groups. CONCLUSIONS: Although both @entity3 and @entity5 provide adequate general anesthesia, @entity5 may be preferable in super @entity1 @entity0 because of superior hemodynamic stability and faster recovery from anesthesia.

title: Anesthesia management for the super XXXX : is @entity5 superior to @entity3 as a sole anesthetic agent? A double-blind randomized controlled trial.

answer: @entity1


abstract: OBJECTIVE: General anesthesia in @entity1 @entity0 is both challenging and demanding. With the rates of @entity1 in the general population increasing, more @entity0 undergo bariatric surgery. The aim of this study was to compare the performance, effectiveness and recovery from anesthesia of @entity5 and @entity3 in combination with @entity4 , with and without bispectral index (BIS) monitoring in super @entity1 @entity0 undergoing bariatric surgery. @entity0 AND METHODS: In this prospective, double-blind, randomized, controlled study a total of 100 super @entity1 @entity0 (body mass index, BMI > 50 kg/m2) undergoing bariatric surgery were randomly allocated in four groups: a @entity5 group (n = 25), a @entity5 with BIS monitoring group (n = 25), a @entity3 group (n=25) and a @entity3 with BIS monitoring group (n=25). Hemodynamic parameters, depth of anesthesia, recovery from anesthesia and @entity2 were recorded. RESULTS: The mean age of @entity0 was 37.7    9.2 years and the median BMI was 57.86    9.33. There were no statistically significant differences between the four groups with respect to @entity0 characteristics, comorbidities and duration of surgery. The intraoperatively mean arterial pressure was significantly higher in both @entity3 groups. No significant difference was observed between the four groups in respect to heart rate changes during anesthesia. Although the time to eye-opening and extubation was significantly shorter in both @entity3 groups, recovery from anesthesia, assessed with the Aldrete, Chung and White recovery scores, was significantly faster in @entity5 groups. No significant difference was observed in @entity2 between the four groups. CONCLUSIONS: Although both @entity3 and @entity5 provide adequate general anesthesia, @entity5 may be preferable in super @entity1 @entity0 because of superior hemodynamic stability and faster recovery from anesthesia.

title: Anesthesia management for the super @entity1 : is @entity5 superior to XXXX as a sole anesthetic agent? A double-blind randomized controlled trial.

answer: @entity3


abstract: OBJECTIVES: The incidence of @entity2 , @entity1 in particular, is increasing rapidly. Consequently, specific recommendations for sun-protection measures now exist. This survey set out to assess the compliance of the general population with these guidelines. METHODS: The French nationwide observational survey, EDIFICE @entity1 , was conducted (28 September to 20 October 2011) through phone interviews of a representative sample of 1502 subjects aged >=   18  years, using the quota method. Sun-protection was defined as frequent or systematic use of clothes or sunscreen. The group of individuals who declared exposure to the sun (N  =  1172) was subdivided: risk-takers (N  =  442), and those who used sun protection (N  =  730). RESULTS: Risk-takers were significantly more often male (62% vs. 44%, P  <  0.01), had a lower level of education (40% vs. 26%, P  <  0.01), lower incomes (2587 @entity3 vs. 2948 @entity3 /month) and were more often smokers (42% vs. 31%, P  <  0.01). In contrast, age, marital status and use of sunbeds were not significantly different between the two groups. Interestingly, risk-takers had less risk factors for @entity1 . However, they were less well-informed about high-risk exposure and optimal use of sunscreen. Sun-protection measures for their @entity0 were less stringent than those of the group who used sun protection: systematic/frequent use of sunglasses (42% vs. 59%, P  <  0.01), systematic use of sunscreen (77% vs. 86%, P  <  0.01), and frequent renewal (69% vs. 82%, P  <  0.01), high sun protection factors (SPF) (46% vs. 56%, P  <  0.01), use of clothing (84% vs. 92%, P  <  0.01) and hats (88% vs. 94%, P  <  0.01). CONCLUSIONS: Risk-takers are characterized by a lesser understanding of sun-protection measures and behaviours. Their @entity0 benefit less from protective measures than those of @entity0 who use sun protection themselves. Improved understanding may well improve behaviours; one can therefore legitimately predict a considerable impact on parents' attitude to their own protection and that of their @entity0 .

title: XXXX risk-takers: fathers and sons.

answer: @entity1


abstract: UNASSIGNED: There are differences in reporting @entity2 complications after transcatheter aortic valve implantation (TAVI), which is a consequence of the lack of consensus for their definition. Furthermore, the amount of data on the impact of peri-procedural @entity2 on the mid-term prognosis is still limited. The aim of this study was to investigate the incidence, predictors, and impact of life-threatening and major bleedings as defined by the Valve Academic Research Consortium 2 (VARC-2) in @entity0 after TAVI over the mid-term prognosis.Consecutive @entity0 who underwent TAVI from March 2010 to December 2013 were included. All data were classified according to the VARC-2 criteria. We assessed the incidence and the predictors of @entity2 ( @entity2 ), defined as life-threatening/disabling (LT/D) or major @entity2 , and analyzed their impact on 30-day and 1-year clinical outcome.A total of 129 @entity0 were included (79.1    8.3 years; mean EuroSCORE = 17.8    12.7). The @entity2 occurred in 25 @entity0 (19.4%), of which 9 (7.0%) had LT/D and 16 (12.4%) had major @entity2 . @entity3 ( @entity3 ) access (OR 4.38, 95% CI 2.13-14.29, P = 0.01) and @entity1 (OR 2.93, 95% CI 1.08-7.93, P = 0.03) were identified as independent predictors of @entity2 . @entity0 with @entity2 had higher 30-day mortality (20.0% versus 4.0% P = 0.02) and 1-year mortality (40.0% versus 11.1%, P < 0.002). @entity2 independently predicted 1-year, all-cause mortality (HR 5.88, 95% CI 1.7319,94, P = 0.005). @entity2 are frequent after TAVI and are associated with decreased short and mid-term survival. @entity1 and @entity3 access are independent risk factors for @entity2 .

title: Incidence, Predictors and Impact of Severe Periprocedural Bleeding According to VARC-2 Criteria on 1-Year Clinical Outcomes in XXXX After Transcatheter.

answer: @entity0


abstract: BACKGROUND: The objective of this study was to investigate the relationship between @entity1 -associated in @entity3 and @entity0 clinical characteristics. We also examined the role of @entity1 -associated in @entity3 in the proliferation and apoptosis in @entity6 . MATERIAL AND METHODS: @entity1 -associated in @entity3 expression was analysed in 65 @entity5 -embedded tissue specimens of salivary @entity6 and 25 adjacent non-cancerous tissues by immunohistochemistry (IHC). We used RNA interference technology to silence @entity1 -associated in @entity3 expression in ACCM cells. Cell Counting Kit-8 tests, transwell experiments and flow cytometry were used to test the proliferation, @entity4 resistance, migration, invasion and apoptosis of ACCM cells. RESULTS: @entity1 -associated in @entity3 nuclear and cytoplasmic expression in salivary @entity6 tissue was higher than in the adjacent normal salivary tissue. The expression level was closely associated with @entity2 histological grading, perineural invasion and surrounding @entity2 invasion. The downregulation of @entity1 -associated in @entity3 expression inhibited proliferation and induced apoptosis in ACCM cells. The knock-down of @entity1 -associated in @entity3 expression had no effect on migration, invasion and chemoresistance. CONCLUSIONS: @entity1 -associated in @entity3 may have an important role in @entity2 development in @entity6 . @entity1 -associated in @entity3 is a potential biomarker for @entity6 .

title: The expression of MACC1 and its role in the proliferation and apoptosis of salivary XXXX .

answer: @entity6


abstract: UNASSIGNED: Recent advances in neuroradiological techniques have increasingly improved the diagnosis rate for @entity2 , particularly with the widespread use of three-dimensional cerebral angiography. However, the treatment of @entity2 remains a considerable challenge for neurosurgeons. Endovascular coiling has emerged as a potential treatment option for @entity1 . The aim of the present study was to evaluate the safety and efficacy of Solitaire AB stent-assisted coiling embolization for the treatment of ruptured very small @entity1 . This retrospective study included nine consecutive @entity0 with ruptured very small @entity1 ( <=3 mm) that underwent Solitaire AB stent-assisted coiling embolization. The @entity2 were located in the ophthalmic branch of the internal carotid artery (n=2), the posterior communicating branch of the internal carotid artery (n=4), the top of the basilar artery (n=1) and the middle cerebral artery (n=2). Solitaire AB stents were successfully implanted in all nine @entity0 . Of the nice individuals, six @entity0 exhibited complete occlusion at Raymond grade I and three @entity0 exhibited occlusion at Raymond grade II. No @entity5 was observed during the surgery. During the follow-up period of 8-13 months, no @entity4 occurred. A total of seven @entity0 underwent follow-up digital subtraction angiography at 5-10 months post-intervention. No recurrence of the @entity2 and no @entity3 or occlusion of the parent arteries was observed. Therefore, Solitaire AB stent-assisted coil embolization was demonstrated to be a safe and effective treatment for ruptured very small @entity1 . The long-term efficacy of this technique may be improved by increasing the packing density around the aneurysmal neck and improving the hemodynamics.

title: Solitaire AB stent-assisted coiling embolization for the treatment of ruptured very small XXXX .

answer: @entity1


abstract: Many deaths of wild birds that have drunk water contaminated with hepatotoxic @entity1 -producing cyanobacteria have been reported. A mass @entity0 of egrets and herons with @entity2 were found at the agricultural reservoir occurring cyanobacterial waterblooms. This study aimed to verify a hypothesis that the egrets and herons which died in the reservoir drink @entity1 -producing cyanobacteria and @entity1 involves in the cause of @entity0 as well as the symptoms of @entity2 . The cyanobacterial community in gastric contents of egrets and herons that died from @entity2 was assessed using cyanobacterial 16S rRNA-based terminal-restriction fragment length polymorphism (T-RFLP) profiling and a cyanobacterial 16S rRNA-based clone library analysis. In addition, PCR amplification of the mcyB-C region and the mcyG gene, involved in @entity1 biosynthesis, was examined. The cyanobacterial community in the gastric contents of two birds showed a simplistic composition. A comparison of cyanobacterial T-RFLP profiling and cloned sequences suggested that the genus Microcystis predominated in both samples of egrets died. Although we confirmed that two egrets which died in the reservoir have taken in cyanobacterial waterblooms containing the genus Microcystis, no mcy gene was detected in both samples according to the mcy gene-based PCR analysis. This study is the first to show the profiling and traceability of a cyanobacterial community in the gastric contents of wild birds by molecular analysis. Additionally, we consider causing symptoms of @entity2 in the dead egrets.

title: Molecular Analysis of the Cyanobacterial Community in Gastric Contents of Egrets with Symptoms of XXXX .

answer: @entity2


abstract: BACKGROUND AND OBJECTIVES: Many surface proteins are implicated in nasopharyngeal colonization and pathogenesis of @entity1 . Some of these factors are candidate antigens for protein based vaccines. New vaccine designs focus on the surface proteins (e. g., pspA and pspC) and also cytolysin, and pneumolysin. In this study, 3 key virulence genes, lytA, pspC, and rrgA, which encoded surface proteins, were detected among @entity2 isolates. MATERIALS AND METHODS: A total of 260 nasopharyngeal swabs were collected from healthy @entity0 under 6 years old attending day care centers in Mashhad, Iran. Isolates of @entity2 were confirmed by optochin susceptibility and colony appearance and also by PCR for cpsA gene. The presence of lytA, pspC, and rrgA genes were also detected by PCR. RESULTS: A total of 59 isolates were confirmed as @entity2 . Among these isolates, 50 (84.74%), 19 (32.20%), and 2 (3.38%) were positive for lytA, rrgA, and pspC genes respectively. The presence of these genes among @entity2 isolates were as follows: 1) rrgA, lytA, pspC (1 isolate), 2) rrgA, lytA(17isolates), 3) pspC (2 isolate), 4) lytA (50 isolates). CONCLUSION: cpsA gene was specific for detection of @entity2 isolates which were colonized in nasopharynx. The lytA gene was the most frequent gene among the @entity2 isolates, and combination of rrgA, lytA was the most observed pattern. Thus, it is important for future monitoring of vaccine formulation in our country.

title: Detection of lytA, pspC, and rrgA genes in XXXX isolated from healthy @entity0 .

answer: @entity1


abstract: BACKGROUND AND OBJECTIVES: Many surface proteins are implicated in nasopharyngeal colonization and pathogenesis of @entity1 . Some of these factors are candidate antigens for protein based vaccines. New vaccine designs focus on the surface proteins (e. g., pspA and pspC) and also cytolysin, and pneumolysin. In this study, 3 key virulence genes, lytA, pspC, and rrgA, which encoded surface proteins, were detected among @entity2 isolates. MATERIALS AND METHODS: A total of 260 nasopharyngeal swabs were collected from healthy @entity0 under 6 years old attending day care centers in Mashhad, Iran. Isolates of @entity2 were confirmed by optochin susceptibility and colony appearance and also by PCR for cpsA gene. The presence of lytA, pspC, and rrgA genes were also detected by PCR. RESULTS: A total of 59 isolates were confirmed as @entity2 . Among these isolates, 50 (84.74%), 19 (32.20%), and 2 (3.38%) were positive for lytA, rrgA, and pspC genes respectively. The presence of these genes among @entity2 isolates were as follows: 1) rrgA, lytA, pspC (1 isolate), 2) rrgA, lytA(17isolates), 3) pspC (2 isolate), 4) lytA (50 isolates). CONCLUSION: cpsA gene was specific for detection of @entity2 isolates which were colonized in nasopharynx. The lytA gene was the most frequent gene among the @entity2 isolates, and combination of rrgA, lytA was the most observed pattern. Thus, it is important for future monitoring of vaccine formulation in our country.

title: Detection of lytA, pspC, and rrgA genes in @entity1 isolated from healthy XXXX .

answer: @entity0


abstract: BACKGROUND: Early coronary angiography and computed tomography are recommended in survivors of out-of-hospital @entity4 (OHCA). However, both techniques require iodinated contrast agent although the effects on incident @entity2 are unknown. The aim of this study was to explore the incidence of @entity2 ( @entity2 ) and need for renal replacement therapy (RRT) in @entity0 after nontraumatic OHCA with special regard to the administration of contrast agent during the early in-hospital diagnostic workup. MATERIALS AND METHODS: Data from all survivors of OHCA admitted to our hospital between 1  January  2008 and 30  June  2015 were retrospectively collected. Incidence of @entity2 and RRT between the contrast and no contrast groups were compared. RESULTS: Of 280  OHCA survivors, 133 (47.5   %) received contrast agent (227.0        136.5  ml). Within 72  h after hospital admission, 47 of 129 survivors (36.4   %) developed @entity2 of any stage, but @entity2 was more common in @entity0 without early contrast administration than in @entity0 with early contrast administration (54.5 vs. 28.2   %; p   =   0.011). @entity0 who survived until hospital discharge had higher serum @entity3 levels at admission than at hospital discharge (1.17        0.37 vs. 0.92        0.35; p   <   0.001). CONCLUSION: @entity2 is common in survivors of OHCA, and RRT following OHCA is needed more frequently than in other @entity1 . Despite elevated serum @entity3 levels at admission, we could not show an association between early contrast administration in survivors of OHCA and @entity2 incidence.

title: [Acute kidney injury and renal replacement therapy in victims from out-of-hospital XXXX with administration of contrast agent].

answer: @entity4


abstract: UNASSIGNED: Our objective was to evaluate the safety and clinical efficacy of autologous M2 macrophage transplantation in non-acute @entity3 @entity0 . We also evaluated whether the intrathecal administration of macrophages influences the production of cytokines by peripheral blood cells, and whether the levels of cytokines correlate with @entity3 severity and responsiveness to celltherapy. For this, thirteen @entity0 (12 males and one female with median 63 years) diagnosed with @entity2 (n=10) or @entity8 (n=3) @entity3 have been subjected to cell transplantation therapy (study group). On average 21.9 x 10(6) of autologous M2 macrophages were injected via intrathecal introduction. Thirteen matched case-control @entity3 @entity0 who did not receive cell therapy formed the control group. We did not observe any serious adverse events, i.e. intrahospital mortality, neurological worsening and @entity6 , related to the cell injection. One @entity0 in the study group and two @entity0 in the control group died during the 6-mo follow-up period due to the recurrent @entity3 . In the study group the NIHSS score decreased from 11 to 6 (p=0.007) in 6 mo after the therapy, whereas the @entity0 in the control group showed a less pronounced neurological improvement (the NIHSS score decreased from 11 to 8; p=0.07). The obvious positive response (the improvement of the NIHSS score >= 3) in the study group was observed in 75% versus 18% in the control group (pFET=0.03). M2-cell introduction did not significantly affect the production of various cytokines. Nevertheless, pretreated levels of @entity10 , @entity11 and @entity13 correlated with @entity3 severity. Moreover, responder @entity0 were differed from non-responders by lower spontaneous production of @entity11 , @entity7 , PDGF, @entity1 and higher stimulation indexes of @entity12 , @entity4 , @entity5 and @entity9 . These findings suggest that the intrathecal administration of autologous M2 cells in @entity3 @entity0 is safe and leads to a better neurological recovery, which could be mediated through the immunomodulatory activity of M2 macrophages.

title: Safety and therapeutic potential of M2-macrophages in XXXX treatment.

answer: @entity3


abstract: OBJECTIVE: The aim of the present study was to clarify the relationship between the stand-up test and gait speed, @entity5 ( @entity4 ), and @entity2 using calcaneal quantitative ultrasound. STUDY DESIGN: Cross-sectional study. METHODS: A total of 185 subjects (55 @entity0 , 130 @entity0 ) aged >= 40 years (mean age, 63.7 years; range, 40-79 years) were evaluated using the stand-up test to screen for @entity3 . We also assessed @entity4 of the knee using X-rays and a subjective questionnaire, physical characteristics, 6-m gait speed (m/s), and bone density. If results on the stand-up test were worse than benchmarks by age group (i.e., the height at which 50% of each age group could stand-up), the subject was defined as having a risk for @entity3 (L group). We analyzed the relationship between the stand-up test and other variables. RESULTS: Of 185 subjects, 50 (27.0%) were classified into the L group. In univariate analysis, there were significant differences between the L group and non-L group in bone density (p  <  0.001), gait speed (p  <  0.001), @entity2 (p  <  0.001), @entity1 ( @entity1 ) (cut off 1  m/s), and Japanese @entity5 measure score. Multivariate logistic regression analysis adjusted for age, height, weight, and gender showed a significant association between the stand-up test and bone density (OR 0.960, 95% confidence interval (95% CI) 0.927-0.994), gait speed (m/s) (OR 0.073, 95% CI 0.016-0.342), @entity2 (OR 3.710, 95% CI 1.410-9.764), and @entity1 (OR 7.849, 95% CI 1.628-37.845). CONCLUSIONS: The stand-up test to screen for the risk for @entity3 was associated with bone density, gait speed, @entity2 , @entity1 . The stand-up test is an easy test to use to screen for possible disability among the elderly.

title: Relation between the stand-up test and gait speed, XXXX , and @entity2 using calcaneal quantitative ultrasound - Cross-sectional study.

answer: @entity5


abstract: OBJECTIVE: The aim of the present study was to clarify the relationship between the stand-up test and gait speed, @entity5 ( @entity4 ), and @entity2 using calcaneal quantitative ultrasound. STUDY DESIGN: Cross-sectional study. METHODS: A total of 185 subjects (55 @entity0 , 130 @entity0 ) aged >= 40 years (mean age, 63.7 years; range, 40-79 years) were evaluated using the stand-up test to screen for @entity3 . We also assessed @entity4 of the knee using X-rays and a subjective questionnaire, physical characteristics, 6-m gait speed (m/s), and bone density. If results on the stand-up test were worse than benchmarks by age group (i.e., the height at which 50% of each age group could stand-up), the subject was defined as having a risk for @entity3 (L group). We analyzed the relationship between the stand-up test and other variables. RESULTS: Of 185 subjects, 50 (27.0%) were classified into the L group. In univariate analysis, there were significant differences between the L group and non-L group in bone density (p  <  0.001), gait speed (p  <  0.001), @entity2 (p  <  0.001), @entity1 ( @entity1 ) (cut off 1  m/s), and Japanese @entity5 measure score. Multivariate logistic regression analysis adjusted for age, height, weight, and gender showed a significant association between the stand-up test and bone density (OR 0.960, 95% confidence interval (95% CI) 0.927-0.994), gait speed (m/s) (OR 0.073, 95% CI 0.016-0.342), @entity2 (OR 3.710, 95% CI 1.410-9.764), and @entity1 (OR 7.849, 95% CI 1.628-37.845). CONCLUSIONS: The stand-up test to screen for the risk for @entity3 was associated with bone density, gait speed, @entity2 , @entity1 . The stand-up test is an easy test to use to screen for possible disability among the elderly.

title: Relation between the stand-up test and gait speed, @entity5 , and XXXX using calcaneal quantitative ultrasound - Cross-sectional study.

answer: @entity2


abstract: UNASSIGNED: A 58-year-old @entity0 with a history of a heavy @entity3 intake was admitted to hospital for a 3-weeks history of abdominal discomfort, @entity4 , @entity5 and an increased abdominal girth that appeared progressively after an @entity9 due to an @entity11 . On physical examination, @entity8 was present and the abdomen was distended with no tenderness on palpation. Laboratory studies showed an increased white-cell count, an elevated @entity10 and abnormal liver-function tests. Abdominal ultrasonography showed a large fluid collection in the right side of the abdomen. An abdominal computed tomography scan revealed a @entity7 perforation communicating to a big subcapsular hepatic biloma of 9.5 by 25.0 by 35.0 centimeters, which was compressing the liver and other intraabdominal organs. Finally, our @entity0 underwent an open cholecystectomy with @entity12 , and a partial resection of the Glisson's capsule. Macroscopic and microscopic examination of the resected specimens confirmed the diagnosis of @entity7 perforation. Gallbladder @entity1 is a rare entity. The diagnosis represents a challenge because of its low incidence, its association with other lesions of vital organs and the nonspecific and insidious symptoms that can produce. Treatment depends on the type and severity of the damage caused; nevertheless, cholecystectomy remains the treatment of choice in @entity0 with @entity6 or @entity2 of the @entity7 . To our knowledge, this is the first report in the English literature of an isolated blunt @entity1 that was associated with the development of a large biloma.

title: Giant biloma as a result of a blunt XXXX : A case report.

answer: @entity9


abstract: OBJECTIVES: We had for aim to determine the risk factors for acquiring @entity3 -intermediate or -resistant Gram-negative bacilli (CR-GNB) in an intensive care unit (ICU) and to identify the resistance mechanisms involved. @entity0 AND METHODS: We conducted an observational prospective cohort study during 6 months in medical and surgical ICUs of the Besan  on Teaching Hospital. @entity0 with acquired CR-GNB were @entity0 whose cultures (screening or diagnosis) became positive more than 48h after admission to the ICU. The risk factors for ICU-acquired CR-GNB were determined by multivariate logistic regression. CR-GNB isolates were typed by pulsed-field gel electrophoresis (PFGE) and screened for resistance mechanisms with phenotypic and genotypic tests. RESULTS: Twenty-three of the 347 included @entity0 had acquired a CR-GNB. The multivariate analysis revealed significant associations between this acquisition and the duration of previous treatments with @entity4 - @entity6 (adjusted odds ratio [aOR], 1.13, P=0.02) and @entity1 (aOR, 1.62; P=0.005), but not with carbapenems. The CR-GNB strains were identified as @entity2 (n=10), @entity7 (n=7), and @entity5 (n=6). No acquired carbapenemase-producing strain was identified. PFGE typing identified 1 multiple clone among @entity2 isolates (4 @entity0 ), whereas for the other bacteria, all the strains were different. CONCLUSION: Our study results suggest that the strategy to prevent the emergence and spread of CR-GNB should not be limited to the sole restriction of @entity3 use in ICU settings.

title: Acquisition of XXXX -resistant Gram-negative bacilli in intensive care unit: Predictors and molecular epidemiology.

answer: @entity3


abstract: UNASSIGNED: The main goal of this work was to study the effect of Aurora kinase expression on cell ploidy and tumorigenesis. Fifty invasive @entity0 , 50 diffuse large @entity6 and 10 reactive lymph node samples were recruited in the study. Because of the significant correlation with the overall cell proliferation rate, the overexpression of @entity9 could not be stated on the basis of kinase expressing @entity1 cell fractions alone. The relative expression of @entity9 kinase is better reflected by the AMI index which represents the @entity9 expression in relation to the whole proliferative fraction of the @entity1 . A higher relative @entity9 expression was associated with higher mitotic activity in @entity6 . FISH analysis of the @entity9 locus did not show any gains or amplifications in the samples analyzed. On the other hand, we have observed the loss of the gene in @entity0 and @entity2 samples as well. A strong correlation was shown between @entity9 and @entity4 copy numbers: @entity9 loss was associated with @entity4 deletion in all samples. According to our results on @entity0 , losses at 17p13.1 and chromosome 17 aneusomy determined by FISH showed a statistically significant correlation. Our study presents the frequent occurrence of chromosome 17 aneusomy in @entity0 and @entity6 samples. Chromosome 17 aneusomy evaluated by FISH correlated with @entity7 determined by flow cytometry. Direct correlation between kinase expression and ploidy could not be shown. The highest AMI values were seen in B-ALCL samples, and it was associated with high chromosome 17 copy numbers and mitotic activity. The damaged @entity9 kinase function results in @entity5 in the CPC complex leading to @entity8 , while @entity4 deficiency helps malignant cells to survive due to insufficient activation of the intrinsic apoptotic pathways. The upregulation of @entity9 function may cause error in an important mitotic checkpoint, thus resulting in induction of aneuploid cell populations. These parallel effects finally increase the complexity of @entity3 and generate aneuploid cell populations.

title: [Biologic mechanisms of XXXX and chromosome number changes in @entity1 ].

answer: @entity3


abstract: UNASSIGNED: The main goal of this work was to study the effect of Aurora kinase expression on cell ploidy and tumorigenesis. Fifty invasive @entity0 , 50 diffuse large @entity6 and 10 reactive lymph node samples were recruited in the study. Because of the significant correlation with the overall cell proliferation rate, the overexpression of @entity9 could not be stated on the basis of kinase expressing @entity1 cell fractions alone. The relative expression of @entity9 kinase is better reflected by the AMI index which represents the @entity9 expression in relation to the whole proliferative fraction of the @entity1 . A higher relative @entity9 expression was associated with higher mitotic activity in @entity6 . FISH analysis of the @entity9 locus did not show any gains or amplifications in the samples analyzed. On the other hand, we have observed the loss of the gene in @entity0 and @entity2 samples as well. A strong correlation was shown between @entity9 and @entity4 copy numbers: @entity9 loss was associated with @entity4 deletion in all samples. According to our results on @entity0 , losses at 17p13.1 and chromosome 17 aneusomy determined by FISH showed a statistically significant correlation. Our study presents the frequent occurrence of chromosome 17 aneusomy in @entity0 and @entity6 samples. Chromosome 17 aneusomy evaluated by FISH correlated with @entity7 determined by flow cytometry. Direct correlation between kinase expression and ploidy could not be shown. The highest AMI values were seen in B-ALCL samples, and it was associated with high chromosome 17 copy numbers and mitotic activity. The damaged @entity9 kinase function results in @entity5 in the CPC complex leading to @entity8 , while @entity4 deficiency helps malignant cells to survive due to insufficient activation of the intrinsic apoptotic pathways. The upregulation of @entity9 function may cause error in an important mitotic checkpoint, thus resulting in induction of aneuploid cell populations. These parallel effects finally increase the complexity of @entity3 and generate aneuploid cell populations.

title: [Biologic mechanisms of @entity3 and chromosome number changes in XXXX ].

answer: @entity1


abstract: UNASSIGNED: Predicting unfavorable outcome is of paramount importance in clinical decision making. Accordingly, we designed this multinational study, which provided the largest case series of @entity10 ( @entity10 ). 43 centers from 14 countries (Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria, @entity4 ) submitted data of microbiologically confirmed @entity10 @entity0 hospitalized between 2000 and 2012. Unfavorable outcome was defined as survival with significant sequela or @entity3 . In developing our index, binary logistic regression models were constructed via 200 replicates of database by bootstrap resampling methodology. The final model was built according to the selection frequencies of variables. The severity scale included variables with arbitrary scores proportional to predictive powers of terms in the final model. The final model was internally validated by bootstrap resampling. A total of 507 @entity0 ' data were submitted among which 165 had unfavorable outcome. Eighty-six @entity0 died while 119 had different neurological sequelae in 79 (16  %) @entity0 . The full model included 13 variables. Age, @entity5 , @entity6 , altered consciousness, @entity7 , @entity8 , immunosuppression, @entity1 and @entity2 remained in the final model. Scores 1-3 were assigned to the variables in the severity scale, which included scores of 1-6. The distribution of mortality for the scores 1-6 was 3.4, 8.2, 20.6, 31, 30 and 40.1  %, respectively. @entity9 , @entity1 , immunosuppression, @entity2 , @entity7 , and @entity8 predicted the unfavorable outcome in the scoring and the cumulative score provided a linear estimation of prognosis.

title: Hamsi scoring in the prediction of unfavorable outcomes from XXXX : results of Haydarpasa-II study.

answer: @entity10


abstract: BACKGROUND: Mutations of @entity9 , @entity12 , @entity10 , and @entity11 genes are associated with @entity2 , including @entity3 ( @entity4 with @entity3 ) in @entity0 . However, the source of Wnt ligands and their signaling effects on the orofacial morphogenetic process remain elusive. RESULTS: Using @entity6 -Cre to impair Wnt secretion through the inactivation of @entity13 /mWls, we investigate the relevant regulation of Wnt production and signaling in nasal-facial development. Ectodermal ablation of @entity13 leads to severe @entity1 resulting from dramatically reduced cell proliferation and increased cell death due to a combined loss of WNT, FGF and @entity8 signaling in the developing facial prominence. In the invaginating nasal pit, the @entity13 disruption also causes a detrimental effect on migration of the olfactory epithelial cells into the mesenchymal region. The blockage of Wnt secretion apparently impairs the olfactory epithelial cells through modulation of @entity7 signaling. CONCLUSIONS: Our study thus suggests the head ectoderm, including the facial ectoderm and the neuroectoderm, as the source of canonical as well as non-canonical Wnt ligands during early development of the nasal-facial prominence. Both @entity5 dependent and independent signaling pathways are required for proper development of these morphogenetic processes. This article is protected by copyright. All rights reserved.

title: Ectodermal Wnt controls nasal pit morphogenesis through modulation of the XXXX /FGF/ @entity7 signaling axis.

answer: @entity8


abstract: BACKGROUND: Mutations of @entity9 , @entity12 , @entity10 , and @entity11 genes are associated with @entity2 , including @entity3 ( @entity4 with @entity3 ) in @entity0 . However, the source of Wnt ligands and their signaling effects on the orofacial morphogenetic process remain elusive. RESULTS: Using @entity6 -Cre to impair Wnt secretion through the inactivation of @entity13 /mWls, we investigate the relevant regulation of Wnt production and signaling in nasal-facial development. Ectodermal ablation of @entity13 leads to severe @entity1 resulting from dramatically reduced cell proliferation and increased cell death due to a combined loss of WNT, FGF and @entity8 signaling in the developing facial prominence. In the invaginating nasal pit, the @entity13 disruption also causes a detrimental effect on migration of the olfactory epithelial cells into the mesenchymal region. The blockage of Wnt secretion apparently impairs the olfactory epithelial cells through modulation of @entity7 signaling. CONCLUSIONS: Our study thus suggests the head ectoderm, including the facial ectoderm and the neuroectoderm, as the source of canonical as well as non-canonical Wnt ligands during early development of the nasal-facial prominence. Both @entity5 dependent and independent signaling pathways are required for proper development of these morphogenetic processes. This article is protected by copyright. All rights reserved.

title: Ectodermal Wnt controls nasal pit morphogenesis through modulation of the @entity8 /FGF/ XXXX signaling axis.

answer: @entity7


abstract: UNASSIGNED: @entity2 ( @entity2 ) is the most aggressive @entity3 , with 12-15 months median survival time despite current treatment efforts. Among the alternative treatment approaches that have gained acceptance over the last decade is the use of replication-competent oncolytic adenoviruses, which are promising due to their relatively low @entity1 and @entity0 -specific targeting. Three-dimensional (3D) @entity0 models can mimic the physiological microenvironment of @entity2 @entity0 and provide valuable information about the interaction between @entity0 cells and adenoviruses. Therefore, robust in vitro 3D @entity0 models are critical to investigate the mechanisms underlying @entity0 progression and explore the @entity1 effect of the adenovirus on @entity0 cells. In this study, we used a hydrogel microwell platform to generate in vitro 3D @entity2 spheroids and studied their interactions with the Delta-24-RGD adenovirus. The results showed that the cultured 3D spheroids were successfully infected by the Delta-24-RGD. A significant cell lysis was observed. Cell viability was decreased approximately 37%, 54% and 65% with 10, 50, and 100 MOIs, respectively. The infection of the Delta-24-RGD was found more effective on 3D spheroids when compared to 2D monolayer cell culture. These results implicate that our hydrogel microwell platform could provide a promising 3D model to investigate the oncolytic potential of the viruses in vitro.

title: Delta-24-RGD Induces XXXX Spheroids in Three Dimensional PEG Microwells.

answer: @entity1


abstract: AIM: To elucidate the clinicopathological characteristics of clinically early @entity3 in the upper-third stomach and to clarify treatment precautions. METHODS: A total of 683 @entity0 with clinical early @entity3 were enrolled in this retrospective study, 128 of whom had @entity3 in the upper-third stomach (U group). All @entity0 underwent a double contrast barium examination, endoscopy, and computed tomography (CT), and were diagnosed preoperatively based on the findings obtained. The clinicopathological features of these @entity0 were compared with those of @entity0 with @entity3 in the middle- and lower-third stomach (ML group). We also compared clinicopathological factors between accurate-diagnosis and under-diagnosis groups in order to identify factors affecting the accuracy of a preoperative diagnosis of @entity2 depth. RESULTS: @entity0 in the U group were older (P = 0.029), had a higher ratio of males to females (P = 0.015), and had more histologically differentiated @entity2 (P = 0.007) than @entity0 in the ML group. A clinical under-diagnosis occurred in 57 out of 683 @entity0 (8.3%), and was more frequent in the U group than in the ML group (16.4% vs 6.3%, P < 0.0001). Therefore, the rates of lymph node @entity1 and lymphatic invasion were slightly higher in the U group than in the ML group (P = 0.071 and 0.082, respectively). An under-diagnosis was more frequent in histologically undifferentiated @entity2 (P = 0.094) and in those larger than 4 cm (P = 0.024). The median follow-up period after surgery was 56 mo (range, 1-186 mo). Overall, survival and disease-specific survival rates were significantly lower in the U group than in the ML group (P = 0.016 and 0.020, respectively). However, limited operation-related @entity2 recurrence was not detected in the U group in the present study. CONCLUSION: Clinical early @entity3 in the upper-third stomach has distinguishable characteristics that increase the risk of a clinical under-diagnosis, especially in @entity0 with larger or undifferentiated @entity2 .

title: Clinicopathological characteristics of clinical early XXXX in the upper-third stomach.

answer: @entity3


abstract: OBJECTIVE: To determine the most accurate, noninvasive method of assessing @entity3 . STUDY DESIGN: The following data sources were searched: electronic databases, gray literature, scientific meetings, reference lists, and authors of unpublished studies. Eligible studies were comparative outpatient evaluations that used an accepted reference standard and were conducted in developed countries in @entity0 aged <18  years with @entity2 . Data extraction was completed independently by multiple reviewers before a consensus was made. RESULTS: Nine studies that included 1039 @entity0 were identified. The 4-item @entity1 ( @entity1 ), the "Gorelick" score, and unstructured physician assessment were evaluated in 3, 2, and 5 studies, respectively. Bedside ultrasound, capillary digital videography, and urinary measurements were each evaluated in one study. The @entity1 had a positive likelihood ratio (LR) range of 1.87-11.79 and a negative LR range of 0.30-0.71 to predict 6% @entity3 . When combined with the 4-item Gorelick Score, the positive LR was 1.93 (95% CI 1.07-3.49) and negative LR was of 0.40 (95% CI 0.24-0.68). Unstructured @entity3 assessment had a pooled positive LR of 2.13 (95% CI 1.33-3.44) and negative LR of 0.48 (95% CI 0.28-0.82) to detect >= 5% @entity3 . CONCLUSIONS: Overall, the clinical scales evaluated provide some improved diagnostic accuracy. However, test characteristics indicate that their ability to identify @entity0 both with and without @entity3 is suboptimal. Current evidence does not support the routine use of ultrasound or urinalysis to determine @entity3 severity.

title: Diagnosing Clinically Significant Dehydration in XXXX with Acute Gastroenteritis Using Noninvasive Methods: A Meta-Analysis.

answer: @entity0


abstract: Serum samples were obtained from 26 beef @entity0 with uterine prolapse and from 15 with minor @entity2 (controls). The serum of animals with uterine prolapse had significantly lower @entity1 concentration (mean +/- S.D. = 8,22 +/- 0,69 mg/dL, P</=0,01), higher @entity3 concentration (mean +/- S.D. = 4,78 +/- 1,75 mg/dL, P</=0,05) and lower @entity1 to @entity3 ratios (mean +/- S.D. = 1,99 +/- 0,88, P</=0,01) than for the control animals (means +/- S.D. = 8,91 +/- 0,75 mg/dL, 3,54 +/- 1,41 mg/dL and 2,99 +/- 1,41 respectively). Mild @entity4 (6,9 mg/dL-7,9 mg/dL) was present in 11 (42,3%) of the @entity0 with prolapse as compared to only one (6,7%) of the controls. @entity5 was present in 11 (42,3%) of the animals with prolapse and in ten (66,7%) of the controls. Eighteen (69,2%) of the animals with prolapse were alert and ambulatory when treated and 15 (57,7%) were known to have required help to deliver the @entity0 . Of the @entity0 group with uterine prolapse, 14 (53,8%) were two years old, six (23,1%) were three years old, and six (23,1%) were four years of age or older. It was concluded that mild @entity4 and some degree of @entity2 were associated with the uterine prolapses. The @entity3 results were equivocal but the high incidence of @entity5 may reflect a @entity3 deficient diet.

title: Observations on uterine prolapse in beef XXXX .

answer: @entity0


abstract: UNASSIGNED: To improve the efficacy of transcatheter arterial chemoembolization (TACE) for @entity2 ( @entity2 ), this study evaluated the prevalence and causes of extrahepatic arteries (EHAs) and identified feeding arteries in HCCs in three independent clinical groups in a single inverventional radiology center. Between November 2011 and September 2012, 942 cases of @entity2 were included in this retrospective study. The @entity0 were treated in three independent groups of 285, 301 and 356 @entity0 , respectively. Enhanced computed tomography, enhanced magnetic resonance imaging and digital subtraction angiography were reviewed retrospectively and correlations between the presence of @entity1 -feeding EHAs and @entity1 number, size and location in the liver, number of repeat TACE procedures and complications were assessed. There were 698 EHAs in the 942 cases of @entity2 , with 182, 233 and 283 EHAs in the three independent groups, respectively. @entity1 size was associated with EHA formation; the percentages of @entity0 with EHAs were 2.7  3.0, 5.5  0.5, 43.2  4.0, 61.8  5.2 and 93.4  1.8% with @entity1 sizes of 2-3, 3-5, 5-7, 7-9 and >9 cm, respectively. There were 159  19 EHAs in each group feeding @entity1 in peripheral locations in the liver, but only 48.7  6.8 in the central zone. The most common EHA was the @entity3 , with a mean of 101.0  14.1 per group. The number of EHAs increased proportionally with the number of TACE sessions. The number of EHAs was positively associated with @entity1 size, peripheral location of the @entity1 and number of TACE sessions.

title: Evaluation of extrahepatic collateral arteries in XXXX in three independent groups in a single center.

answer: @entity2


abstract: Fifty-seven @entity0 with @entity7 (GCTs) treated at our center between 1962 and 1979 were evaluated to determine 1) the prognostic value of disease stage, @entity2 histology, primary site, and @entity0 age; 2) results of therapy; and 3) patterns of @entity1 . The 35 @entity0 and 22 @entity0 were from 1 week to 18 years old (median 5 yr). Primary sites were ovarian (20), testicular (10), sacrococcygeal (12), retroperitoneal (7), mediastinal (5), and other (3). Cox regression analysis indicated that stage was the most important prognostic variable. @entity2 were usually advanced at diagnosis, but @entity2 site did not have prognostic value independent of disease stage. Neither @entity0 age nor @entity2 histology significantly influenced outcome. Drugs active against malignant GCTs included @entity6 , @entity3 , and @entity9 in combination and @entity10 , @entity5 , and @entity4 . Radiation alone cured nondisseminated @entity8 . The most common sites of @entity1 were lungs, liver, central nervous system, and bone; other sites were infrequently involved. We conclude that stage was the most important prognostic variable, extragonadal @entity2 were usually advanced at diagnosis, and similarities in the histogenesis, metastatic pattern, and response to therapy, regardless of primary site, justify the consideration of childhood malignant GCTs as one group.

title: XXXX in 57 @entity0 and adolescents.

answer: @entity7


abstract: Fifty-seven @entity0 with @entity7 (GCTs) treated at our center between 1962 and 1979 were evaluated to determine 1) the prognostic value of disease stage, @entity2 histology, primary site, and @entity0 age; 2) results of therapy; and 3) patterns of @entity1 . The 35 @entity0 and 22 @entity0 were from 1 week to 18 years old (median 5 yr). Primary sites were ovarian (20), testicular (10), sacrococcygeal (12), retroperitoneal (7), mediastinal (5), and other (3). Cox regression analysis indicated that stage was the most important prognostic variable. @entity2 were usually advanced at diagnosis, but @entity2 site did not have prognostic value independent of disease stage. Neither @entity0 age nor @entity2 histology significantly influenced outcome. Drugs active against malignant GCTs included @entity6 , @entity3 , and @entity9 in combination and @entity10 , @entity5 , and @entity4 . Radiation alone cured nondisseminated @entity8 . The most common sites of @entity1 were lungs, liver, central nervous system, and bone; other sites were infrequently involved. We conclude that stage was the most important prognostic variable, extragonadal @entity2 were usually advanced at diagnosis, and similarities in the histogenesis, metastatic pattern, and response to therapy, regardless of primary site, justify the consideration of childhood malignant GCTs as one group.

title: @entity7 in 57 XXXX and adolescents.

answer: @entity0


abstract: BACKGROUND: In May 2012, there were increasing @entity1 cases and deaths reported from Nabua, Camarines Sur to the Philippines event-based surveillance system. An investigation was conducted to identify risk factors and determine transmission dynamics. METHODS: A suspected case was defined as a resident of Nabua with at least three episodes of watery @entity1 per day from 16 March to 22 June 2012. A confirmed case was defined as a suspected case positive for @entity2 . An environmental investigation was conducted and rectal swabs and water samples sent to the national reference laboratory for bacterial isolation. A 1:2 case-control study matching for age and sex was conducted. Data were analysed using Epi Info. RESULTS: There were 309 suspected cases with two deaths, and the most affected age group was @entity0 under five years (45%). Eight cases were positive for @entity2 Ogawa El Tor and one for Non-01. Water samples were positive for faecal coliforms and @entity4 . The case-control study showed that cases had a higher odds than controls of using unchlorinated water sources (odds ratio [OR]  =  3.6; 95% confidence interval [CI]:1.6-8.5) and having toilets located within 20 m of a septic tank (OR  =  2.7; 95% CI: 1.4-5.3). In multivariate analysis, the only significant factor was drinking from piped water (OR  =  0.21; 95% CI: 0.09-0.49). DISCUSSION: In this @entity3 outbreak, drinking-water from unchlorinated wells was a significant risk factor. Future @entity3 control efforts should include not just improving water and sanitation systems but also intensified behaviour change campaigns.

title: Availability of safe drinking-water: the answer to XXXX outbreak? Nabua, Camarines Sur, Philippines, 2012.

answer: @entity3


abstract: INTRODUCTION: Opponensplasty is a surgical option for @entity0 with severe @entity2 ( @entity2 ). We investigated prognostic factors of @entity0 lacking preoperative compound muscle action potential (CMAP) of the abductor pollicis brevis (APB) muscle to determine the necessity for single-stage opponensplasty. METHODS: We retrospectively enrolled 22 hands of 22 @entity2 @entity0 . Prognostic factors considered were age, @entity1 , the median sensory nerve action potential, distal motor latency of the second lumbrical (2L) CMAP (2L-DML), and its amplitude (2L-Amp). Postoperative APB-CMAP amplitude (post APB-Amp) at 12 months was used as the outcome measure. RESULTS: Only 2L-DML showed a significant correlation with post APB-Amp (r = -0.56). The contribution of 2L-Amp was not significant, although 3 hands with absent 2L-CMAP had a poor electrophysiological recovery. DISCUSSION: Prolonged 2L-DML and absent 2L-CMAP seem to be poor prognostic factors. Concurrent opponensplasty may not be necessary in @entity0 with 2L-DML of 8 ms or less. This article is protected by copyright. All rights reserved.

title: Prognosis of severe XXXX with absent compound muscle action potential.

answer: @entity2


abstract: OBJECTIVES: We report in this singlecenter study our results of a five-year experience in the administration of @entity2 spray (LS) during ultrasound-guided prostate biopsy (TPB). MATERIAL AND METHODS: Between August 2008 and July 2013 a total of 1022 consecutive male @entity0 scheduled for TPB with elevate PSA (>=  4 ng/ml) and (or) abnormal digital rectal and (or) suspect TRUS were considered eligible for the study. Each @entity0 was treated under local anaesthesia with LS (10 gr/100 ml), applied two minutes before the procedure. TPB was performed with the @entity0 in the left lateral decubitus using multi-frequency convex probe "end-fire". Two experienced urologists performed a 14-core biopsy, as first intention. After the procedure each @entity0 was given a verbal numeric @entity1 scale (VNS). The evaluation was differentiated in two scales VNS: VNS 1 for the insertion of the probe and the manoeuvres associated, while VNS 2 only for the @entity1 during needle's insertion. RESULTS: @entity1 scores were not statistically significant different with regard to the values of PSA and prostate gland volume. @entity1 score levels during probe insertion and biopsy were significantly different: the mean @entity1 score according to VNS was 3.3 (2-8) in the first questionnaire (VNS1) (p < 0.001) and 2.1 (1-7) in the second one (VNS2) (p < 0.125). The 8.2% of cases referred severe or unbearable @entity1 (score >=  7), 74% of @entity0 referred no @entity1 at all. Only 21 @entity0 would not ever repeat the biopsy or would request a different type of anaesthesia, while 82% of them would repeat it in the same way. In only eight @entity0 we have not been able to insert TRUS probe. CONCLUSIONS: Our @entity1 score data suggest that LS provides efficient @entity0 comfort during TPB reducing @entity1 both during insertion of the probe and the needle. This non-infiltrative anaesthesia is safe, easy to administer, psychologically well accepted by @entity0 and of low cost.

title: XXXX spray administration in transrectal ultrasound-guided prostate biopsy: Five years of experience.

answer: @entity2


abstract: OBJECTIVES: To investigate the effect of stretch-and-flow voice therapy on vocal function and handicap. STUDY DESIGN: Randomized controlled trial. METHODS: @entity0 with primary @entity1 dysphonia were randomly assigned to experimental or control groups. Experimental @entity0 received vocal hygiene education followed by 6 weeks of stretch-and-flow voice therapy. Control @entity0 received vocal hygiene education only. Outcome variables consisted of a measure of @entity2 (Voice Handicap Index [VHI]), maximum phonation time, s/z ratio, and acoustic measures. All measures were obtained at baseline prior to treatment and within 2 weeks posttreatment or at the end of the control period. The pre- to posttreatment measurement change (delta   ) was applied to statistical analyses. RESULTS: A multivariate analysis of variance revealed significant group differences in pre-to-post changes on measures of VHI, maximum phonation time, and cepstral peak prominence (CPP) in connected speech and vowels (P   =   0.003, 0.013, 0.025, and 0.017 respectively), with a significant reduction of VHI (Cohen's d   =   1.6), increase in maximum phonation time (Cohen's d   =   1.2), increase of CPP in connected speech (Cohen's d   =   1.2), and increase of CPP in vowels (Cohen's d   =   1.1) in the experimental group compared to the control group. CONCLUSIONS: This preliminary small sample randomized controlled trial found significantly greater improvement in @entity2 , maximum phonation time, and acoustic measures of vocal function after @entity0 received stretch-and-flow voice therapy compared to @entity0 receiving vocal hygiene education alone. Additional research incorporating larger samples will be needed to confirm and further investigate these findings. LEVEL OF EVIDENCE: 1b. Laryngoscope, 2015.

title: A randomized controlled trial of stretch-and-flow voice therapy for XXXX Dysphonia.

answer: @entity1


abstract: Morphologic studies were made of cuspal tears and perforations in 16 porcine valve bioprostheses that had been implanted in 14 @entity0 (9 male and 5 female) ranging in age from 2 to 65 years. Eleven bioprostheses had been in the mitral position for 30 to 123 months, four in the aortic position for 15 to 40 months and one in a varied pulmonary conduit for 96 months. The cuspal lesions were classified into four types. Type I lesions, which involved the free edges of the cusps, were the most common of all lesions and occurred with equal frequency in mitral and aortic bioprostheses. Regardless of position of implantation, @entity1 were more frequent in the right coronary cusp than in the other cusps. Ultrastructural study showed that these lesions develop as consequences of breakdown of collagen at the free edges of the cusps, usually near the commissures. @entity1 consisted of linear perforations that extended along the basal regions of the cusps, forming an arc parallel to the sewing ring. These lesions were uncommon an resulted from separation of bundles of collagen. @entity1 , which were large, round or oval perforations that occupied central regions of the cusps, were more common in aortic than in mitral bioprostheses. They were characterized by marked destruction of cuspal tissue and were most frequently associated with @entity2 . @entity1 were small pinhole-like perforations; they usually were multiple, localized in central regions of the cusps and associated with @entity3 . @entity1 were more common in mitral than in aortic bioprostheses. Regardless of position, they were more frequent in the left and noncoronary cusps than in the right coronary cusp (which may be protected by its muscle shelf against this type of perforation). It is concluded that cuspal tears and perforations develop in implanted bioprostheses as consequences of structural failure of connective tissue components.

title: Structure and classification of cuspal tears and perforations in porcine bioprosthetic cardiac valves implanted in XXXX .

answer: @entity0


abstract: UNASSIGNED: In seed plants, new axes of growth are established by the formation of meristems, groups of pluripotent cells that maintain themselves and initiate the formation of lateral organs. After embryonic development, secondary shoot meristems form in the boundary zones between the shoot apical meristem and leaf primordia, the leaf axils. In addition, many plant species develop ectopic meristems at different positions of the plant body. In the compound @entity0 leaf, ectopic meristems can initiate at the base of leaflets, which are delimited by two distinct boundary zones, referred to as the proximal (PLB) and distal ( @entity1 ) leaflet boundaries. We demonstrate that the two leaflet boundaries differ from each other and that ectopic meristem formation is strictly limited to the @entity1 . Our data suggest that the @entity1 harbours a group of pluripotent cells that seems to be the launching pad for meristem formation. Initiation of these meristems is dependent on the activities of the transcriptional regulators Goblet (Gob) and Lateral suppressor (Ls), specifically expressed in the @entity1 . Gob and Ls act in hierarchical order, because Ls transcript accumulation is dependent on Gob activity, but not vice versa. Ectopic meristem formation at the @entity1 is also observed in other seed plants, like Cardamine pratensis, indicating that it is part of a widespread developmental program. Ectopic meristem formation leads to an increase in the number of buds, enhances the capacity for survival and opens the route to vegetative propagation. This article is protected by copyright. All rights reserved.

title: Lateral suppressor and Goblet act in hierarchical order to regulate ectopic meristem formation at the base of XXXX leaflets.

answer: @entity0


abstract: BACKGROUND: We report our surgical series of 35 @entity0 with giant nonfunctioning @entity5 (GNFPA). We analyzed the rule of Ki-67 antigen expression in predicting recurrence. METHODS: Thirty-five @entity0 were operated between 2000 and 2010. Suprassellar extension of the @entity1 were classified according to Hardy and Mohr based on magnetic resonance (MR) studies. Pituitary endocrine function and MR scans were assessed preoperatively and at 1, 6, and 12 months postoperatively. Immunohistochemical studies were based in regard to the expression of the proliferative Ki-67 index and the hormonal receptor for luteinizing hormone, follicle stimulating hormone, @entity6 , thyroid stimulating hormone, adrenocorticotropic hormone, and prolactin. Tumors specimens were obtained from 35 @entity0 with GNFPA. Endoscopic transsphenoidal surgery was the approach of choice. RESULTS: Thirty-five @entity0 were submitted to 49 surgeries, 44 (89.8%) were transsphenoidal and 5 (10.2%) were transcranial. The most frequent preoperative complaints were @entity3 and @entity3 in 25 (71.2%) and 23 (65.7%) cases, respectively. Improvement of visual acuitiy and @entity3 after surgery was seen in 20 (80%) and 17 (73.9%) @entity0 , respectively. @entity2 were encountered in 20 @entity0 (57.1%). After surgery, 18 @entity0 (51.4%) required hormonal replacement. Three @entity0 had @entity3 related to @entity7 and recovered after surgery. The Ki-67 @entity4 ( @entity4 ) ranged from <1% to 4.8%. The rate of recurrence in @entity1 with Ki-67 <3% was 7.7% (2 @entity0 ), Ki-67 >3% was present in 5 @entity0 and the recurrence committed 3 @entity0 . CONCLUSION: In our series, regardless the improvement of visual function and compressing symptoms, 5 @entity0 with expression of Ki-67 @entity4 more than 3% experienced a recurrence.

title: Nonfunctioning XXXX : Invasiveness and recurrence.

answer: @entity5


abstract: Labeled @entity1 , @entity2 , @entity8 , @entity10 , @entity9 , and @entity4 were administered to @entity0 stomachs in a vascular perfusion system. Sections of gastric fundus and antrum, and of the duodenal glands, were studied by light-microscopic autoradiography. The rate of incorporation of radioactive label in the various mucous cell types of the antrum and of the duodenal glands was measured by counting the @entity3 grains over each cell type and comparing this rate with that of the surface mucous cells of the fundus. The following major observations were made: The patterns of incorporation in the mucous cells on the surface and in the pits of the antrum did not differ essentially from those of the surface mucous cells of the fundus. On the contrary, the incorporation patterns of the surface mucous cells of the fundus differed considerably from those of the mucous cells of the antral glands and from the mucous cells of the duodenal glands. The mucous cells of the antral glands showed a lower incorporation rate of @entity6 and of ( @entity5 ) @entity7 , especially of @entity8 and @entity10 , but a higher incorporation rate of @entity4 . The mucous cells of the duodenal glands showed a considerably higher rate of incorporation for @entity2 , but a lower rate for @entity10 . No differences were seen for @entity1 , @entity8 , and @entity4 . The relatively low synthetic activity of the mucous cells of antral glands correlates well with the various amounts of RER, Golgi system, and secretory granules, found in these cells, and with the histochemical staining characteristics of their mucous granules. The mucous cells of the duodenal glands are characterized by typical parallel arrays of their numerous RER cisternae and by a low number of small secretory granules.

title: Glycoprotein synthesis in the mucous cells of the vascularly perfused XXXX stomach. III. Mucous cells of the antrum and the duodenal glands.

answer: @entity0