abstract: UNASSIGNED: Objective: To evaluate the effect of comprehensive intervention by health education and medical intervention to @entity2 Uyghur @entity0 in low-income rural areas in Xinjiang, China. Method: A multistaged (prefecture-county-township-village) stratified cluster random sampling method was used to select @entity0 in southern Xinjiang. Twelve villages in Jiangbazi Township in Jiashi County were chosen. These villages were randomly divided into six intervention groups and six control groups, and local Uyghur aged 18 years or older residing in the village for at least 6 months were interviewed for a baseline prevalence study and to select @entity0 for two years of comprehensive intervention including low dose @entity3 and the effects of the interventions were observed. Results: A total of 655 @entity0 (347 @entity0 in the intervention groups, 308 @entity0 in the control groups) were randomly selected from 12 villages in Jiangbazi Township, follow-up rate is 87.0%. Compared to baseline mean levels of TG and LDL-C were reduced by 1.39 mmol/L (p < 0.01) and 2.12 mmol/L (p < 0.01) respectively and levels of HDL-C increased by1.22 mmol/L (p < 0.01) in the intervention group. Lipids were controlled in 38.61% of the intervention groups vs. 3.57% of the control groups (p < 0.01). Compared with baseline lipid levels, TG, TC, LDL-C and HDL-C was significantly improved, compared with it was in control groups. Conclusions: Blood lipid levels of Uygur @entity0 with @entity2 can be effectively improved through health education combined with low-dose @entity4 administration. This suggests that national strategies in public health be developed to improve the treatments to @entity1 .

title: An Evaluation on the Effect of Health Education and of Low-Dose Statin in XXXX among @entity1 in Far Western China: A Comprehensive Intervention Study.

answer: @entity2


abstract: Forty-six female @entity2 were used. Twelve days after mating, all the fetuses were removed and fetal membrane with yolk sac were left outside of the uterus following the method reported by Sorbis and Vandeputte (1974). About the half of the @entity2 were ovariectomized at the laparotomy. The @entity2 were killed at 20 and 40 weeks after treatment and examined. No difference was observed in @entity1 incidence between fetectomy alone and fetectomy plus ovariectomy at both 20 and 40 weeks and it was about 70%. The size of @entity1 varied from 2 to 35 mm in diameter. The size of @entity1 tended to be greater in fetectomy plus ovariectomy compared with fetectomy alone at 20 weeks, but no significant difference was observed at 40 weeks between the two groups. Histologically the @entity1 were characterized by the presence of a variety of differentiated tissues. @entity0 to the visceral part were detected in 2 @entity2 of fetectomy alone and the @entity1 were diagnosed as yolk sac @entity1 . These results indicate that sex @entity3 might influence the teratocarcinogenesis.

title: [Experimental teratoma by fetectomy in the XXXX : influence of ovariectomy (author's transl)].

answer: @entity2


abstract: INTRODUCTION: @entity4 proved its efficacy in relapsed @entity2 (STS) in 3 multicenter phase II studies with selected @entity0 . The aim of the present study is to investigate @entity4 efficacy and tolerance in a cohort of "real-life" unselected @entity0 with @entity2 . METHODS: A single-center analysis was carried out on all consecutive @entity0 with histologically proven unresectable advanced or metastatic STS, who received at least one cycle of @entity4 . Data on efficacy and tolerance were retrospectively reported. RESULTS: From 2004 to 2014, data of 59 @entity0 were reviewed. Median age was 62 years (from 23 to 87). A total of 317 cycles of @entity4 were administered. Twenty-five @entity0 (42%) suffered grade 3-4 hematological @entity1 , mainly with @entity3 (22 @entity0 , 37%). Disease control rate was 24%, mainly with stable disease, and 45 @entity0 (76%) experienced disease progression. Median overall survival was 6.6 months (95%CI [4.9-12.6]). CONCLUSION: @entity4 might be an option for @entity0 without any other validated alternative, but phase III study evaluating @entity4 +best supportive care (BSC) versus BSC is necessary.

title: What makes real world outcomes in soft @entity2 ? A mono-institutional XXXX experience.

answer: @entity4


abstract: INTRODUCTION: @entity4 proved its efficacy in relapsed @entity2 (STS) in 3 multicenter phase II studies with selected @entity0 . The aim of the present study is to investigate @entity4 efficacy and tolerance in a cohort of "real-life" unselected @entity0 with @entity2 . METHODS: A single-center analysis was carried out on all consecutive @entity0 with histologically proven unresectable advanced or metastatic STS, who received at least one cycle of @entity4 . Data on efficacy and tolerance were retrospectively reported. RESULTS: From 2004 to 2014, data of 59 @entity0 were reviewed. Median age was 62 years (from 23 to 87). A total of 317 cycles of @entity4 were administered. Twenty-five @entity0 (42%) suffered grade 3-4 hematological @entity1 , mainly with @entity3 (22 @entity0 , 37%). Disease control rate was 24%, mainly with stable disease, and 45 @entity0 (76%) experienced disease progression. Median overall survival was 6.6 months (95%CI [4.9-12.6]). CONCLUSION: @entity4 might be an option for @entity0 without any other validated alternative, but phase III study evaluating @entity4 +best supportive care (BSC) versus BSC is necessary.

title: What makes real world outcomes in soft XXXX ? A mono-institutional @entity4 experience.

answer: @entity2


abstract: @entity9 was utilized in 70 @entity0 with symptomatic, sustained refractory @entity2 . Of these, 29 had @entity3 (20 recurrent @entity4 and nine sustained @entity10 ). Control was achieved in eight with @entity10 and in 16 with @entity4 . Recurrence has been prevented in these 24 @entity0 (83%) during an average follow-up of 13.4 months. An additional 41 @entity0 had recurrent @entity6 . In 19 with symptoms consisting of @entity7 without @entity5 or clinically apparent hemodynamic compromise, treatment was limited to @entity9 . Of these, 14 responded (74%) and have been free of @entity3 during an average follow-up of 13 months. In 22 who had experienced either @entity5 or life-threatening @entity1 , @entity9 was added to those agents which had only partially suppressed advanced grades of @entity8 . Fourteen of these @entity0 (64%) have remained free pf recurrent @entity3 during an average follow-up of 12 months. After drug loading, maintenance therapy consisted of a daily dose ranging from 200 to 600 mg. Only mild side effects have been encountered in the 17 @entity0 (23%) with any untoward responses. This experience confirms that oral @entity9 is an effective and safely applied agent against recurrent refractory @entity10 and sustained intractable @entity6 with moderate symptoms. While also efficacious in refractory sustained life-threatening @entity6 , usage of the agent is often difficult in this condition owing in part to insufficient information concerning @entity9 pharmacokinetics.

title: XXXX therapy in symptomatic, sustained refractory @entity10 .

answer: @entity9


abstract: @entity9 was utilized in 70 @entity0 with symptomatic, sustained refractory @entity2 . Of these, 29 had @entity3 (20 recurrent @entity4 and nine sustained @entity10 ). Control was achieved in eight with @entity10 and in 16 with @entity4 . Recurrence has been prevented in these 24 @entity0 (83%) during an average follow-up of 13.4 months. An additional 41 @entity0 had recurrent @entity6 . In 19 with symptoms consisting of @entity7 without @entity5 or clinically apparent hemodynamic compromise, treatment was limited to @entity9 . Of these, 14 responded (74%) and have been free of @entity3 during an average follow-up of 13 months. In 22 who had experienced either @entity5 or life-threatening @entity1 , @entity9 was added to those agents which had only partially suppressed advanced grades of @entity8 . Fourteen of these @entity0 (64%) have remained free pf recurrent @entity3 during an average follow-up of 12 months. After drug loading, maintenance therapy consisted of a daily dose ranging from 200 to 600 mg. Only mild side effects have been encountered in the 17 @entity0 (23%) with any untoward responses. This experience confirms that oral @entity9 is an effective and safely applied agent against recurrent refractory @entity10 and sustained intractable @entity6 with moderate symptoms. While also efficacious in refractory sustained life-threatening @entity6 , usage of the agent is often difficult in this condition owing in part to insufficient information concerning @entity9 pharmacokinetics.

title: @entity9 therapy in symptomatic, sustained refractory XXXX .

answer: @entity10


abstract: Groups of pregnant @entity0 were injected with two successive daily doses of @entity1 from gestational day 12 and 13 (E12 + 13) until the day before parturition (E21 + 22) in order to label in their embryos the proliferating precursors of neurons. At 60 days of age the proportion of neurons generated (or no longer labeled) on specific @entity2 was determined quantitatively in 14 nuclei of the pontine region. Peak production time of neurons of the trigeminal mesencephalic nucleus was on day E11 or earlier, with a small proportion generated on day E12. Peak production time of the trigeminal motor neurons was on day E12, with a small proportion produced earlier. Neurons of the principal sensory nucleus were generated between days E13 and @entity3 , with a peak on day E14; the late-produced neurons tended to belong to a class of intermediate and large cells. The bulk of the neurons of the supratrigeminal and infratrigeminal nuclei arose on days E15 and @entity3 . Neurons of the locus coeruleus are produced mostly on day E12, with about 20% of the cells arising on day E13. The bulk of the neurons of the dorsal tegmental nucleus (Gudden's) are produced between days E13 and E15, whereas most of the neurons of the deep (ventral) tegmental nucleus are produced on day E15. A dorsal-to-caudal gradient was also obtained between the dorsal and ventral nuclei of the lateral lemniscus, the neurons of the former being generated between days E12 and E15; the latter, between days E13 and E17. The neurons of both the pars lateralis and the pars medialis of the parabrachial nucleus were produced simultaneously between days E13 and E15, with a peak on day E13. The heterogeneous collection of neurons of the pontine paramedial reticular formation was produced for day E11 (or earlier) until day E15. Finally, the neurons of the raphe pontis parvicellularis were generated at an even rate between days E13 and E15, whereas the bulk of the neurons of the raphe pontis magnocellularis were produced on days E15 and @entity3 . On the basis of datings obtained for 9 subdivisions of the entire brain stem trigeminal complex, hypotheses were offered of the cytogenetic components of the system. The sequence of neuron production in the dorsal and deep tegmental nuclei was related to their connections with divisions of the mammillary and habenular nuclei on a "first come-first serve" basis.

title: Development of the brain stem in the XXXX . IV. Thymidine-radiographic study of the time of origin of neurons in the pontine region.

answer: @entity0


abstract: In this study an attempt was made to determine the relationship between @entity8 ( @entity6 ) and other @entity1 in the aged. The brains of 128 autopsy @entity0 over 60 years of age were examined by both light and electron microscopy. The frequency of cerebral @entity6 increased with age and was 58 percent in @entity0 over the age of 90. The change was observed more often in @entity0 than in @entity0 . In 7 cases of severe @entity6 , the temporal or occipital cortex was the most common site. Most cases of @entity6 were complicated by the formation of senile plaques in the cortex. Electron microscopic examination revealed amyloid fibrils deposited in clusters in the media and adventitia of the vessels, destroying their structure. Some blood vessels on the surface of the cortex showed @entity7 , angionecrosis, duplication of the wall, or @entity2 . @entity6 is sometimes a cause of @entity5 . Five cases of massive @entity5 were found among @entity0 aged 90 or older, including a temporal @entity4 in a 92-year-old @entity0 which was believed to be due to the marked @entity6 noted in the temporal lobes. Small cortical @entity3 were common in the temporal lobes.

title: XXXX in the elderly.

answer: @entity8


abstract: BACKGROUND: Superparamagnetic @entity0 nanoparticles (SPIONs) are the most commonly used negative MRI contrast agent which affect the transverse (T2) relaxation time. The aim of the present study was to investigate the impact of various polymeric coatings on the performance of @entity1 nanoparticles as MRI contrast agents. METHODS: Ferrofluids based on @entity1 ( @entity2 ) nanoparticles (SPIONs) were synthesized via chemical co-precipitation method and coated with different biocompatible polymer coatings including @entity3 , chitosan and dextran. RESULTS: The bonding status of different polymers on the surface of the @entity1 nanoparticles was confirmed by the Fourier transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). The vibrating sample magnetometer (VSM) analysis confirmed the superparamagnetic behavior of all synthesized nanoparticles. The field-emission scanning electron microscopy (FE-SEM) indicated the formation of quasi-spherical nanostructures with the final average particle size of 12-55 nm depending on the type of polymer coating, and X-ray diffraction (XRD) determined inverse spinel structure of @entity1 nanoparticles. The ferrofluids demonstrated sufficient colloidal stability in deionized water with the zeta potentials of -24.2, -16.9, +31.6 and -21 mV for the naked SPIONs, and for dextran, chitosan and @entity3 coated SPIONs, respectively. Finally, the magnetic relaxivities of water based ferrofluids were measured on a 1.5 T clinical MRI instrument. The r2/r1 value was calculated to be 17.21, 19.42 and 20.71 for the dextran, chitosan and @entity3 coated SPIONs, respectively. CONCLUSIONS: The findings demonstrated that the value of r2/r1 ratio of @entity3 modified SPIONs is higher than that of some commercial contrast agents. Therefore, it can be considered as a promising candidate for T2 MRI contrast agent.

title: The impact of polymer coatings on XXXX nanoparticles performance as MRI contrast agents: a comparative study.

answer: @entity1


abstract: UNASSIGNED: DCIS ( @entity4 in situ) constitutes 15,2% of @entity0 . Conservative surgery coupled with adjuvant radiotherapy is often recommended. The rate of revision surgery is high, from 30 to 60%. The concern is a high quality resection within clear margins with a satisfactory aesthetic result. The objective of this review is to precise the place of oncoplastic surgery in DCIS care. Among risk factors of recurrence, tumoral invasion of surgical margins is capital. In histology, clear margins usually adopted for DCIS are 2mm, even though there is no international consensus. Recent studies show that a 10mm limit would be better. @entity3 caused by surgery, often increased by radiotherapy, has a negative impact on @entity1 quality of life  : oncoplastic surgery may minimize it. Techniques of plastic surgery, arranged into level 1 and 2, allow pushing back conservative treatment limits by removing a larger @entity2 with clear margins. Often used in invasive @entity2 , few data exist regarding oncoplastic surgery and DCIS. It allows to increase the dimensions of surgical resection by 20% and to decrease positive margins significantly therefore the rate of revision surgeries. @entity1 are satisfied with it. Specific indications need to be clarified according to age, size and "comedonecrosis" presence. Oncoplastic surgery should be developed in DCIS specific care.

title: [Oncoplastic breast surgery for the management of XXXX in situ].

answer: @entity4


abstract: BACKGROUND AND PURPOSE: Occlusion of the internal carotid artery puts @entity0 at risk of recurrent @entity2 events because of hemodynamic compromise. Our goal was to characterize clinical and duplex parameters indicating @entity0 at risk of recurrent @entity2 . METHODS: We retrospectively identified @entity0 with @entity3 . Clinical characteristics and ultrasound parameters, including collateral networks, were analyzed. Predictors for recurrent @entity2 were investigated by Cox regression analysis. RESULTS: Of 68 @entity0 , at least 1 recurrent @entity2 event within the same vascular territory was observed in 14 @entity0 (20.6%) within 2 to 92 days (median, 29.5 days). The median follow-up period was 6 months. @entity1 and previous transient @entity2 attack were associated with recurrence, as was activation of the maximum number of collateral pathways on transcranial ultrasound (28.6% versus 5.6%; P=0.03). Furthermore, flow in the posterior cerebral arteries was higher in @entity0 with recurrence in ipsilateral and contralateral posterior cerebral artery P2 segments (76 IQR 37.5 versus 59, IQR 22.5 cm/s and 68, IQR 35.6 versus 52, IQR 21 cm/s; P<0.01 and 0.02). CONCLUSIONS: Flow increases in both posterior cerebral artery P2 segments suggest intensified compensatory efforts when other collaterals are insufficient. Together with the presence of @entity1 and a history of transient @entity2 attack, this duplex parameter indicates that @entity0 with internal carotid artery are at particular risk of recurrent @entity2 .

title: Ultrasound and Clinical Predictors of Recurrent XXXX in Symptomatic Internal Carotid @entity3 .

answer: @entity2


abstract: BACKGROUND AND PURPOSE: Occlusion of the internal carotid artery puts @entity0 at risk of recurrent @entity2 events because of hemodynamic compromise. Our goal was to characterize clinical and duplex parameters indicating @entity0 at risk of recurrent @entity2 . METHODS: We retrospectively identified @entity0 with @entity3 . Clinical characteristics and ultrasound parameters, including collateral networks, were analyzed. Predictors for recurrent @entity2 were investigated by Cox regression analysis. RESULTS: Of 68 @entity0 , at least 1 recurrent @entity2 event within the same vascular territory was observed in 14 @entity0 (20.6%) within 2 to 92 days (median, 29.5 days). The median follow-up period was 6 months. @entity1 and previous transient @entity2 attack were associated with recurrence, as was activation of the maximum number of collateral pathways on transcranial ultrasound (28.6% versus 5.6%; P=0.03). Furthermore, flow in the posterior cerebral arteries was higher in @entity0 with recurrence in ipsilateral and contralateral posterior cerebral artery P2 segments (76 IQR 37.5 versus 59, IQR 22.5 cm/s and 68, IQR 35.6 versus 52, IQR 21 cm/s; P<0.01 and 0.02). CONCLUSIONS: Flow increases in both posterior cerebral artery P2 segments suggest intensified compensatory efforts when other collaterals are insufficient. Together with the presence of @entity1 and a history of transient @entity2 attack, this duplex parameter indicates that @entity0 with internal carotid artery are at particular risk of recurrent @entity2 .

title: Ultrasound and Clinical Predictors of Recurrent @entity2 in Symptomatic Internal Carotid XXXX .

answer: @entity3


abstract: BACKGROUND: Adults with @entity1 may have difficulties with data collection methods such as questionnaires and accelerometry. AIMS: To assess the utility of questionnaires and accelerometry for assessing physical activity (PA) and sedentary behaviour (SB) in non-institutionalised adults with @entity1 . METHODS: @entity0 were recruited from outpatient clinics and community organisations. @entity0 completed PA and SB questionnaires, wore accelerometers for 7   d, and rated the ease/difficulty of completing study components. Recruitment numbers, adherence, and ease/difficulty ratings were examined. Ease/difficulty ratings were compared between study components, and between @entity0 by distress level. RESULTS: One hundred forty-two @entity0 completed the questionnaires; they found it easier to report PA than reclining time (p   =   0.017), and reclining time than sitting time (p   <   0.001). @entity0 with high distress found it more difficult to report sitting time and PA than @entity0 with low distress (p   <   0.017). Ninety-nine @entity0 (70%) completed the accelerometry; the majority (88%) met the minimum wear-time criteria. They found it easier to wear the monitor during the day than while sleeping (p   <   0.001), and easier to complete accelerometry than questionnaires (p   <   0.001). CONCLUSIONS: Accelerometry was more feasible for assessing SB than questionnaires. Questionnaires were feasible for assessing PA, but less acceptable for @entity0 experiencing high distress.

title: The feasibility and acceptability of questionnaires and accelerometry for measuring physical activity and sedentary behaviour in adults with XXXX .

answer: @entity1


abstract: REASONS FOR PERFORMING STUDY: Injury to the superficial @entity2 (SDFT) is common in equids, with a high risk of re-injury associated with changes in @entity0 . In vivo measurement of limb @entity4 has been shown to correlate with @entity0 after injury [1] but requires kinematic analysis which is impractical in a clinical setting. We have developed a simple system for measuring limb @entity4 statically, which could be used as a tool for monitoring SDFT healing. OBJECTIVES: To validate a goniometric measurement of limb @entity4 . STUDY DESIGN: Cross sectional study. METHODS: Initially, forelimb @entity4 indices were determined at the walk for 6 equids using a validated kinematic analysis [1]. Limb @entity4 indices were then calculated using portable floor scales to record ground reaction force (GRF), and an electrogoniometer to record metacarpophalangeal joint angle. Goniometric limb @entity4 indices were subsequently measured in 11 @entity1 ranging from 2 to 20 years of age, with no clinical evidence of @entity3 . Strength and significance of correlation and agreement between the measurement methods was assessed and association between limb @entity4 , limb (left vs. right), weight and age of @entity1 and were calculated. RESULTS: There were strong positive correlations between GRF and joint angle (R(2)   =   0.98) and between the static and kinematic methods (R   =   0.78, P<0.01). There was a positive correlation between limb @entity4 and weight (R(2)   =   0.85, P<0.01), but no association with age or limb. CONCLUSIONS: This study validated the measurement of limb @entity4 in a clinical setting. The positive correlation of limb @entity4 and weight supports the theory of an optimised limb spring [2] for energy-efficient cursorial locomotion which may, in turn, provide a clinically-relevant measure of running efficiency and therefore the quality of @entity3 . Ethical animal research:   Owner consent was obtained. SOURCE OF FUNDING:    None. Competing interests:   None declared.

title: Clinical Research Abstracts of the British XXXX Veterinary Association Congress 2015.

answer: @entity1


abstract: OBJECTIVE: To determine whether the serum level of @entity8 ( @entity8 ), a circulating high-molecular weight glycoprotein and a diagnostic biomarker of @entity1 , is a clinically useful biomarker for detecting chronic @entity5 in @entity0 with severe motor and @entity2 (SMIDS). STUDY DESIGN: @entity0 with SMIDS undergoing videofluorography for assessment of @entity6 were prospectively evaluated. Based on the videofluorography results, the @entity0 were classified into @entity5 and non- @entity5 groups. Age, sex, white blood cell count, and serum levels of @entity7 , @entity3 dehydrogenase, albumin, and @entity8 were compared between the 2 groups. Binary logistic regression was performed to identify factors independently associated with the presence of @entity5 . RESULTS: A total of 66 @entity0 participated in this study, 37 who were classified as the @entity5 group and 29 as the non- @entity5 group. The serum @entity8 level in the @entity5 group was significantly higher than that in the non- @entity5 group (median, 344 U/mL vs 207 U/mL, P  <  .01). Logistic regression modeling showed that the number of prescribed antiepileptic drugs (OR, 1.978; 95% CI, 1.217, 3.214; P  <  .01) and serum @entity8 level (OR, 1.012; 95% CI, 1.005, 1.019; P  <  .01) were independent predictors of @entity5 . CONCLUSIONS: The study demonstrated that the @entity8 level is significantly higher in @entity0 with SMIDS who aspirate than in those who do not. @entity8 shows promise as a biomarker for @entity4 due to @entity5 in these @entity0 .

title: Clinical Usefulness of Serum XXXX for Detecting Chronic Aspiration in @entity0 with Severe Motor and @entity2 .

answer: @entity8


abstract: OBJECTIVE: To determine whether the serum level of @entity8 ( @entity8 ), a circulating high-molecular weight glycoprotein and a diagnostic biomarker of @entity1 , is a clinically useful biomarker for detecting chronic @entity5 in @entity0 with severe motor and @entity2 (SMIDS). STUDY DESIGN: @entity0 with SMIDS undergoing videofluorography for assessment of @entity6 were prospectively evaluated. Based on the videofluorography results, the @entity0 were classified into @entity5 and non- @entity5 groups. Age, sex, white blood cell count, and serum levels of @entity7 , @entity3 dehydrogenase, albumin, and @entity8 were compared between the 2 groups. Binary logistic regression was performed to identify factors independently associated with the presence of @entity5 . RESULTS: A total of 66 @entity0 participated in this study, 37 who were classified as the @entity5 group and 29 as the non- @entity5 group. The serum @entity8 level in the @entity5 group was significantly higher than that in the non- @entity5 group (median, 344 U/mL vs 207 U/mL, P  <  .01). Logistic regression modeling showed that the number of prescribed antiepileptic drugs (OR, 1.978; 95% CI, 1.217, 3.214; P  <  .01) and serum @entity8 level (OR, 1.012; 95% CI, 1.005, 1.019; P  <  .01) were independent predictors of @entity5 . CONCLUSIONS: The study demonstrated that the @entity8 level is significantly higher in @entity0 with SMIDS who aspirate than in those who do not. @entity8 shows promise as a biomarker for @entity4 due to @entity5 in these @entity0 .

title: Clinical Usefulness of Serum @entity8 for Detecting Chronic Aspiration in @entity0 with Severe Motor and XXXX .

answer: @entity2


abstract: OBJECTIVE: To determine whether the serum level of @entity8 ( @entity8 ), a circulating high-molecular weight glycoprotein and a diagnostic biomarker of @entity1 , is a clinically useful biomarker for detecting chronic @entity5 in @entity0 with severe motor and @entity2 (SMIDS). STUDY DESIGN: @entity0 with SMIDS undergoing videofluorography for assessment of @entity6 were prospectively evaluated. Based on the videofluorography results, the @entity0 were classified into @entity5 and non- @entity5 groups. Age, sex, white blood cell count, and serum levels of @entity7 , @entity3 dehydrogenase, albumin, and @entity8 were compared between the 2 groups. Binary logistic regression was performed to identify factors independently associated with the presence of @entity5 . RESULTS: A total of 66 @entity0 participated in this study, 37 who were classified as the @entity5 group and 29 as the non- @entity5 group. The serum @entity8 level in the @entity5 group was significantly higher than that in the non- @entity5 group (median, 344 U/mL vs 207 U/mL, P  <  .01). Logistic regression modeling showed that the number of prescribed antiepileptic drugs (OR, 1.978; 95% CI, 1.217, 3.214; P  <  .01) and serum @entity8 level (OR, 1.012; 95% CI, 1.005, 1.019; P  <  .01) were independent predictors of @entity5 . CONCLUSIONS: The study demonstrated that the @entity8 level is significantly higher in @entity0 with SMIDS who aspirate than in those who do not. @entity8 shows promise as a biomarker for @entity4 due to @entity5 in these @entity0 .

title: Clinical Usefulness of Serum @entity8 for Detecting Chronic Aspiration in XXXX with Severe Motor and @entity2 .

answer: @entity0


abstract: UNASSIGNED: Microvascular decompression (MVD) is an effective and safe treatment option that offers the prospect of definitive cure for hemifacial @entity7 (HFS). However, there are potential risks of complications for MVD associated with @entity1 in particular. The purpose of this study was to identify clinical characteristics of possible complications after MVD for HFS and to establish appropriate management concept of these complications. We retrospectively reviewed medical records of 2040 @entity0 who underwent RmSOC with MVD for HFS at Samsung medical center between January 1998 and March 2013. Of 2040 @entity0 , 2027 were followed (99.4  %). Of the 2027 @entity0 , 1841 (90.8  %) exhibited complete relief or minimal symptoms, and 113 (5.6  %) reported improved @entity7 but had mild remnant symptoms. After operation, the most frequently developed complications were @entity5 (8.19  %), followed by @entity6 (4.90  %) and @entity2 (3.63  %). There were two cases of @entity3 , three cases of @entity4 . MVD was found to be safe and effective treatment for HFS, in consistent with previous reports. Some of the complications such as @entity5 , @entity6 , and @entity2 are relatively common. However, they have mild clinical courses that are usually transient.

title: Postoperative complications of microvascular decompression for hemifacial XXXX : lessons from experience of 2040 cases.

answer: @entity7


abstract: BACKGROUND: Routine use of antifibrinolytic agents in spine surgery is still an issue of debate. OBJECTIVE: To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, @entity2 ( @entity3 ) and @entity4 ( @entity5 , traditionally known as Amicar) in reducing perioperative @entity1 and transfusion requirements in @entity7 surgery. METHODS: We conducted a systematic review and meta-analysis for randomized controlled trials (RCTs), retrospective case-control studies, and retrospective cohort studies on the use of antifibrinolytic agents in @entity7 surgery by searching in the MEDLINE and EMBASE databases and the Cochrane Database of Systematic Reviews and Controlled Trials of papers published from January 1980 through July 2014. Safety of the antifibrinolytic agents was evaluated in all included studies, while efficacy was evaluated in RCTs. RESULTS: Eighteen papers with a total of 1,158 @entity0 were eligible for inclusion in this study. Among them, 8 RCTs with 450 @entity0 were included for evaluation of pharmacologic efficacy (1 RCT was excluded because of a lack of standard deviation data). Mean @entity1 was reduced in @entity0 with perioperative use of antifibrinolytic agents by 409.25 ml intraoperatively (95% confidence interval [CI], 196.57-621.94 ml), 250.30 ml postoperatively (95% CI, 35.31-465.30), and 601.40 ml overall (95% CI, 306.64-896.16 ml). The mean volume of blood transfusion was reduced by 474.98 ml (95% CI, 195.30-754.67 ml). The transfusion rate was 44.6% (108/242) in the patients with antifibrinolytic agents and 68.3% (142/208) in the @entity0 with placebo. (OR 0.38; 95% CI; 0.25-0.58; P<0.00001, I2 = 9%). All studies were included for evaluation of safety, with a total of 8 adverse events reported overall (4 in the experimental group and 4 in the control group). CONCLUSION: The systematic review and meta-analysis indicated that aprotinin, @entity3 , and @entity5 all significantly reduced perioperative @entity1 and transfusion requirements in @entity7 surgery. There was no evidence that the use of antifibrinolytic agents was a risk factor for adverse events, especially @entity6 , in @entity7 surgery.

title: Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative XXXX and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis.

answer: @entity1


abstract: OBJECTIVES: To investigate the radiologic and histological characteristics of biliary intraductal metastasis of advanced @entity1 and the clinical outcomes of percutaneous, metallic stent placement. MATERIALS AND METHODS: We retrospectively assessed 24 @entity0 with @entity3 related to biliary intraductal metastasis of @entity1 who underwent PTBD and subsequent metallic stent placement between 2003 and 2012. RESULTS: Intraductal metastases appeared as uniform, concentric, linear (n   =   17) or band-like (n   =   7), enhanced wall thickening on CT, and 20 @entity0 (83.3  %) had @entity4 . On pathology specimens, malignant cells scattered in the submucosal layer caused a @entity2 . The technical and clinical success rate of stent placement was achieved in all 24 @entity0 . The median survival time was 203  days. Stent occlusion was observed in four @entity0 with 49-278 days following stent placement. The median stent patency time was 156  days. CONCLUSIONS: The radiologic and histological characteristics of biliary intraductal metastasis of advanced @entity1 consist of uniform, linear or band-like, enhanced biliary wall thickening and malignant cells scattered in the submucosal layer, together with the @entity2 without any disruption of the epithelial layer. Uncovered metallic stent placement was also a safe and effective method of palliative treatment in these @entity0 . KEY POINTS:     The CT findings of intraductal metastasis were linear/band-like, enhanced biliary wall thickening.     The histological finding was malignant cells scattered in the submucosal layer.     It showed a @entity2 without any disruption of the epithelial layer.     Uncovered metallic stent placement was a safe and effective palliative treatment.

title: Biliary intraductal metastasis from advanced XXXX : radiologic and histologic characteristics, and clinical outcomes of percutaneous metallic stent placement.

answer: @entity1


abstract: We have previously demonstrated that while VLDL-TG production increased in subjects fed high @entity1 diets, VLDL apo-B production did not change. To further define the effects of high @entity1 diets on apo-B metabolism in @entity0 , we studied the catabolism of this apoprotein in VLDL, IDL, and LDL in three @entity2 subjects during control and high @entity1 diets. 125I-VLDL was injected intravenously into subjects and 18 blood samples obtained over the following 48-hr period. VLDL, IDL, and LDL were isolated by sequential ultracentrifugation at each time point and the specific radioactivity of apo-B in each lipoprotein class was determined. A multicompartmental analysis was utilized to analyze the three radioactivity curves obtained in each study. The major change in apo-B catabolism during the high @entity1 diet involved the conversion of VLDL apo-B to LDL apo-B. During the control diet, 40%--62% of VLDL apo-B was converted to LDL apo-B while during the high @entity1 period, only 16%--42% of VLDL apo-B was converted to LDL. The reduction in conversion resulted from two separate processes. First, direct catabolism of VLDL apo-B without conversion to higher density lipoprotein classes increased during the high @entity1 diet. Second, although during the control period approximately 25% of VLDL apo-B was converted directly to LDL apo-B (without passing through the IDL density range), essentially no VLDL apo-B degradation occurred via this route during the high @entity1 period. Thus, although the rate of VLDL apo-B secretion into plasma was the same during both diet periods, significant alterations in the routes of catabolism of apo-B occurred on the high @entity1 diet.

title: Effect of a high carbohydrate diet on apoprotein-B catabolism in XXXX .

answer: @entity0


abstract: Molecular diagnosis of genetic @entity11 is challenging for non-expert. A targeted next-generation sequencing technology was applied to identify the underlying molecular mechanism of @entity11 and evaluate the contribution of these genes to @entity0 with @entity11 encountered in pediatric endocrinology. A group of unrelated @entity0 (n=82), characterized by @entity3 , dysmorphology and X-ray abnormalities, of which mucopolysacharidoses, @entity7 , @entity5 owing to @entity4 @entity16 mutation had been excluded, were recruited in this study. Probes were designed to 61 genes selected according to the nosology and classification of genetic skeletal disorders of 2010 by Illumina's online DesignStudio software. DNA was hybridized with probes and then a library was established following the standard Illumina protocols. Amplicon library was sequenced on a MiSeq sequencing system and the data were analyzed by MiSeq Reporter. Mutations of 13 different genes were found in 44 of the 82 @entity0 (54%). Mutations of @entity2 gene and @entity10 gene were found in nine @entity0 , respectively (9/44=20%), followed by COMP gene in 8 (18%), @entity14 gene in 4 (9%), @entity6 gene in 4 (9%), @entity8 gene in 3 (6%) and @entity17 , @entity18 , @entity12 , @entity15 , @entity1 , @entity9 , @entity13 gene mutations in one @entity0 each (2% each). In conclusion, mutations of @entity2 , @entity10 and COMP gene are common for @entity3 due to @entity11 in outpatient clinics in pediatric endocrinology. Targeted next-generation sequencing is an efficient way to identify the underlying molecular mechanism of genetic @entity11 .

title: A pilot study of gene testing of genetic XXXX using targeted next-generation sequencing.

answer: @entity11


abstract: OBJECTIVE: To assess age- and sex-specific trends in incidence and 30-day and 1-year case fatality of @entity2 ( @entity2 ) in the Netherlands. METHODS: @entity0 hospitalized for first @entity2 were identified through linkage of the national hospital discharge register and population register using ICD-9 code 431. We identified out-of-hospital deaths in the national cause of @entity1 register. Incidence, 30-day and 1-year case fatality, and total mortality rate were calculated by age and sex. We identified time trends by joinpoint regression analysis and Mann-Kendall tests. RESULTS: We identified 41,068 cases of @entity2 (51% @entity0 ) between 1998 and 2010, of which 6% were out-of-hospital deaths. @entity2 incidence declined in @entity0 and @entity0 younger than 75 years (p  <= 0.01, not significantly in @entity0 35-54 years) but remained stable in @entity0 75 years and older. Thirty-day and 1-year case fatality declined in @entity0 younger than 75 years (not significantly in @entity0 35-54 years). In @entity0 aged 35 to 54 years, @entity2 mortality remained stable until 2003 and then declined slightly (annual percentage change [APC] @entity0 : -7.09%; 95% confidence interval [CI] -11.39 to -2.59; @entity0 : -8.67%; 95% CI -15.18 to -1.66). In @entity0 55 to 74 years, mortality declined in @entity0 between 1995 and 2010 ( @entity4 .55%; 95% CI -5.49 to -3.59) and in @entity0 between 1992 and 2010 ( @entity3 .51%; 95% CI -4.16 to -2.85). Mortality did not decline in @entity0 aged 75 years and older. CONCLUSION: In the Netherlands, @entity2 incidence, case fatality, and mortality rates have declined significantly in @entity0 and @entity0 younger than 75 years but remained stable in @entity0 75 years and older. The observed time trends may be explained by better prevention and treatment during the previous 2 decades of which the elderly do not seem to benefit.

title: Time trends in incidence, case fatality, and mortality of XXXX .

answer: @entity2


abstract: UNASSIGNED: Fear of @entity1 recurrence (FCR) is increasingly recognised as a major concern for @entity0 with @entity1 once active treatment is completed. Several instruments have been designed to assess FCR; however, no gold standard has emerged. Many instruments conceptualise FCR as a multidimensional construct. However, this potentially conflates FCR as an outcome with its antecedents and consequences. This is problematic when an aggregate of distinct dimensions is calculated, as is commonly recommended. For example, the total score on the @entity1 Recurrence Inventory is an aggregate of items from seven sub-scales: triggers, severity, @entity2 , coping strategies, functioning impairments, insight and reassurance. Similarly, the total score on the Fear of Progression Questionnaire is an aggregate of affective reaction, partnership/family, work and loss of autonomy. Arguably, the severity and affective reaction domains represent fear, and the other sub-scales represent related concepts, rather than "dimensions" of FCR. The total score represents a combination of concepts whose meaning is unclear. The same total score could be produced by @entity0 with very different experiences, and @entity0 with the same level of fear could have very different total scores. Therefore, we argue that although the level of FCR may be determined by a complex network of antecedents and modifiers and have variable consequences, FCR itself may be a simple concept, which can be assessed using a smaller number of items. Conceptual clarity in its research infancy should prevent FCR becoming a construct that is vaguely operationalised and interpreted.

title: The sum of all fears: conceptual challenges with measuring fear of XXXX recurrence.

answer: @entity1


abstract: PURPOSE: To evaluate a corneal impression membrane (CIM) for isolation of bacteria, fungi and acanthamoeba in suspected @entity3 . METHODS: Consecutive @entity0 presenting with suspected @entity3 were included. For each @entity0 , samples were collected in a random order using a surgical blade and a 4-mm-diameter @entity1 CIM disc, and transported in brain heart infusion broth. Risk factors, best corrected visual acuity (BCVA), size, location, depth and healing time of the @entity4 were recorded. The microbial isolation rate was used to compare sampling methods. RESULTS: 130 @entity0 were included (mean age 62.6   years, SD 19.0). An antimicrobial had been used prior to presentation in 36 (27.7%) @entity0 . Mean major and minor @entity4 diameters were 2.1   mm (SD 2.0) and 1.6   mm (SD 1.7). Mean healing time was 12.4   days (SD 13.6). BCVA at presentation and following healing was 0.7 (SD 0.7) and 0.62 (SD 0.7) (p=0.34). There were 66 isolates (50.8%); 53 (40.8%) using a CIM and 35 (26.9%) using a blade (p=0.02). @entity2 and coagulase-negative staphylococci were the commonest isolates. Isolation rate was not influenced by organism type, although in four cases Acanthamoeba spp. were isolated; three using CIM and one a blade. CONCLUSIONS: In this study, the isolation of microorganisms from cases of suspected @entity3 was significantly higher using a CIM than a surgical blade. A CIM may be a useful alternative or addition for sample collection in @entity3 .

title: Impression membrane for the diagnosis of XXXX .

answer: @entity3


abstract: BACKGROUND: Return to work (RTW) is a pivotal goal of cardiac rehabilitation (CR) in @entity0 after acute cardiac event. We aimed to evaluate @entity1 ( @entity1 ) parameters as predictors for RTW at discharge after CR. METHODS: We analyzed data from a registry of 489 working-age @entity0 (51.5      6.9  years, 87.9  % @entity0 ) who had undergone inpatient CR predominantly after percutaneous coronary intervention (PCI 62.6  %), coronary artery bypass graft (CABG 17.2  %), or heart valve replacement (9.0  %). Sociodemographic and clinical parameters, noninvasive cardiac diagnostic (2D echo, exercise ECG, 6MWT) and psychodiagnostic screening data, as well as @entity1 findings, were merged with RTW data from the German statutory pension insurance program and analyzed for prognostic ability. RESULTS: During a mean follow-up of 26.5      11.9  months, 373 (76.3  %) @entity0 returned to work, 116 (23.7  %) did not, and 60 (12.3  %) retired. After adjustment for covariates, elective CABG (HR 0.68, 95  % CI 0.47-0.98; p  =  0.036) and work intensity (per level HR 0.83, 95  % CI 0.73-0.93; p  =  0.002) were negatively associated with the probability of RTW. Exercise capacity in @entity1 (in Watts) and the VE/VCO2-slope had independent prognostic significance for RTW. A higher work load increased (HR 1.17, 95  % CI 1.02-1.35; p  =  0.028) the probability of RTW, while a higher VE/VCO2 slope decreased (HR 0.85, 95  % CI 0.76-0.96; p  =  0.009) it. @entity1 also had prognostic value for retirement: the likelihood of retirement decreased with increasing exercise capacity (HR 0.50, 95  % CI 0.30-0.82; p  =  0.006). CONCLUSION: @entity1 is a valid tool for assessing @entity0 ' ability to return to work. Therefore, it may be an essential part of functional assessment during CR for predicting participation in employment.

title: Cardiopulmonary exercise testing is predictive of return to work in cardiac XXXX after multicomponent rehabilitation.

answer: @entity0


abstract: OBJECTIVE: Eosinophilic @entity9 with @entity9 (EGPA) is a systemic @entity7 characterized by @entity5 and blood @entity8 , with the lung being the organ most frequently affected. Oral glucocorticoids and/or immunosuppressive drugs are the mainstay therapy of EGPA. Occasional reports suggest that EGPA @entity0 can be treated with omalizumab in addition to conventional therapy to achieve @entity5 control. To investigate the long-term effects of omalizumab in @entity0 with EGPA and @entity5 (2 females, 3 males, age 41-64 years), we carried out a 36-month follow-up observational study. At the time of enrollment, the @entity0 were on maintenance therapy and had moderate to severe @entity1 , @entity8 and rhinosinusitis. @entity10 / @entity4 and/or histological evidence of tissue eosinophilic infiltration were also present. METHODS: @entity0 were treated with omalizumab (300-600   mg s.c. every 2-4 weeks) as add-on therapy to @entity2 , inhaled @entity3 and bronchodilators. During omalizumab treatment, spirometry, the @entity5 control test (ACT) score and @entity8 were evaluated, and @entity2 dosage was recorded. RESULTS: During the 36 months of omalizumab treatment @entity5 progressively improved as indicated by spirometry and the ACT score. @entity8 progressively decreased. The oral @entity2 dose was reduced or withdrawn during treatment. No adverse events were recorded. CONCLUSIONS: In @entity0 with EGPA and moderate to severe @entity1 , omalizumab can be beneficial and safe. It enables corticosteroid tapering while decreasing @entity8 and @entity6 over 36 months.

title: Omalizumab in @entity0 with eosinophilic XXXX with @entity9 : a 36-month follow-up study.

answer: @entity9


abstract: OBJECTIVE: Eosinophilic @entity9 with @entity9 (EGPA) is a systemic @entity7 characterized by @entity5 and blood @entity8 , with the lung being the organ most frequently affected. Oral glucocorticoids and/or immunosuppressive drugs are the mainstay therapy of EGPA. Occasional reports suggest that EGPA @entity0 can be treated with omalizumab in addition to conventional therapy to achieve @entity5 control. To investigate the long-term effects of omalizumab in @entity0 with EGPA and @entity5 (2 females, 3 males, age 41-64 years), we carried out a 36-month follow-up observational study. At the time of enrollment, the @entity0 were on maintenance therapy and had moderate to severe @entity1 , @entity8 and rhinosinusitis. @entity10 / @entity4 and/or histological evidence of tissue eosinophilic infiltration were also present. METHODS: @entity0 were treated with omalizumab (300-600   mg s.c. every 2-4 weeks) as add-on therapy to @entity2 , inhaled @entity3 and bronchodilators. During omalizumab treatment, spirometry, the @entity5 control test (ACT) score and @entity8 were evaluated, and @entity2 dosage was recorded. RESULTS: During the 36 months of omalizumab treatment @entity5 progressively improved as indicated by spirometry and the ACT score. @entity8 progressively decreased. The oral @entity2 dose was reduced or withdrawn during treatment. No adverse events were recorded. CONCLUSIONS: In @entity0 with EGPA and moderate to severe @entity1 , omalizumab can be beneficial and safe. It enables corticosteroid tapering while decreasing @entity8 and @entity6 over 36 months.

title: Omalizumab in @entity0 with eosinophilic @entity9 with XXXX : a 36-month follow-up study.

answer: @entity9


abstract: OBJECTIVE: Eosinophilic @entity9 with @entity9 (EGPA) is a systemic @entity7 characterized by @entity5 and blood @entity8 , with the lung being the organ most frequently affected. Oral glucocorticoids and/or immunosuppressive drugs are the mainstay therapy of EGPA. Occasional reports suggest that EGPA @entity0 can be treated with omalizumab in addition to conventional therapy to achieve @entity5 control. To investigate the long-term effects of omalizumab in @entity0 with EGPA and @entity5 (2 females, 3 males, age 41-64 years), we carried out a 36-month follow-up observational study. At the time of enrollment, the @entity0 were on maintenance therapy and had moderate to severe @entity1 , @entity8 and rhinosinusitis. @entity10 / @entity4 and/or histological evidence of tissue eosinophilic infiltration were also present. METHODS: @entity0 were treated with omalizumab (300-600   mg s.c. every 2-4 weeks) as add-on therapy to @entity2 , inhaled @entity3 and bronchodilators. During omalizumab treatment, spirometry, the @entity5 control test (ACT) score and @entity8 were evaluated, and @entity2 dosage was recorded. RESULTS: During the 36 months of omalizumab treatment @entity5 progressively improved as indicated by spirometry and the ACT score. @entity8 progressively decreased. The oral @entity2 dose was reduced or withdrawn during treatment. No adverse events were recorded. CONCLUSIONS: In @entity0 with EGPA and moderate to severe @entity1 , omalizumab can be beneficial and safe. It enables corticosteroid tapering while decreasing @entity8 and @entity6 over 36 months.

title: Omalizumab in XXXX with eosinophilic @entity9 with @entity9 : a 36-month follow-up study.

answer: @entity0


abstract: BACKGROUND: Radiation-induced @entity4 is a side effect of radiotherapy in the inner ear for @entity1 of the head and neck. Effective dose constraints for protecting the cochlea are under-reported. The aim of this study is to determine the cochlea dose limitation to avoid causing @entity4 after @entity2 ( @entity2 ) intensity-modulated radiation therapy (IMRT). METHODS: In total 211 @entity0 with @entity2 were included; the side effects of radiotherapy were investigated for 422 inner ears in the cohort. Forty-nine of the four hundred and twenty-two samples (11.6  %) developed grade 2+ @entity5 after IMRT, as diagnosed by a clinician. The Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) criteria were used for @entity4 evaluation. The logistic and Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) models were used for the analyses. RESULTS: The NTCP-fitted parameters were @entity6 50    =   46.31  Gy (95  % CI, 41.46-52.50), y 50    =   1.27 (95  % CI, 1.02-1.55), and @entity6 50    =   46.52  Gy (95  % CI, 41.91-53.43), m   =   0.35 (95  % CI, 0.30-0.42) for the logistic and LKB models, respectively. The suggested guideline @entity6 20 for the tolerance dose to produce a 20  % complication rate within a specific period of time was @entity6 20    =   33.62  Gy (95  % CI, 30.15-38.27) (logistic) and @entity6 20    =   32.82  Gy (95  % CI, 29.58-37.69) (LKB). CONCLUSIONS: To maintain the incidence of grade 2+ @entity4 @entity3 <20  % in IMRT, we suggest that the mean dose to the cochlea should be <32  Gy. However, models should not be extrapolated to other @entity0 populations without further verification and should first be confirmed before clinical implementation.

title: Normal tissue complication probability modeling for cochlea constraints to avoid causing XXXX after head-and-neck intensity-modulated radiation therapy.

answer: @entity4


abstract: OBJECTIVE: Mobile health (mHealth) systems are becoming more common for chronic disease management, but usability studies are still needed on @entity0 ' perspectives and mHealth interaction performance. This deficiency is addressed by our quantitative usability study of a mHealth @entity1 system evaluating @entity0 ' task performance, satisfaction, and the relationship of these measures to user characteristics. MATERIALS AND METHODS: We used metrics in the International Organization for Standardization ( @entity2 ) 9241-11 standard. After standardized training, 10 @entity0 performed representative tasks and were assessed on individual task success, errors, efficiency (time on task), satisfaction (System Usability Scale [SUS]) and user characteristics. RESULTS: Tasks of exporting and correcting values proved the most difficult, had the most errors, the lowest task success rates, and consumed the longest times on task. The average SUS satisfaction score was 80.5, indicating good but not excellent system usability. Data trends showed males were more successful in task completion, and younger @entity0 had higher performance scores. Educational level did not influence performance, but a more recent @entity1 diagnosis did. @entity0 with more experience in information technology (IT) also had higher performance rates. DISCUSSION: Difficult task performance indicated areas for redesign. Our methods can assist others in identifying areas in need of improvement. Data about user background and IT skills also showed how user characteristics influence performance and can provide future considerations for targeted mHealth designs. CONCLUSION: Using the @entity2 9241-11 usability standard, the SUS instrument for satisfaction and measuring user characteristics provided objective measures of @entity0 ' experienced usability. These could serve as an exemplar for standardized, quantitative methods for usability studies on mHealth systems.

title: Quantifying usability: an evaluation of a XXXX mHealth system on effectiveness, efficiency, and satisfaction metrics with associated user characteristics.

answer: @entity1


abstract: The therapeutic efficacy of @entity2 ( @entity3 ) in chronic @entity1 was evaluated in @entity0 who poorly responded to other antibiotics. To 20 @entity0 , @entity3 was administered 2 g b.i.d. intravenously by drip infusion. Clinical efficacy was judged based on the criteria by score. 1. Bacterial elimination rate with @entity3 was 73.7%. 2. A clinical cure rate was 80.0% was obtained by doctors in charge. 3. According to the score assessment, the overall clinical effectiveness rate was 60.0%, clinical symptom cure rate was 85.0% and improvement rate of X-ray findings was 55.0%. 4. Usefulness rate which was assessed by clinical effect and side effect was 70.0%. 5. No side effects and abnormal laboratory findings were observed in this study. We used the new antibiotic @entity3 in @entity0 with chronic @entity1 who responded poorly to other antibiotics and obtained satisfactory results. Especially @entity3 indicated more effective possibility in cases from whom Gram-negative bacilli was isolated.

title: [Clinical study of @entity2 in chronic XXXX : evaluation in poorly responding cases to other antibiotics (author's transl)].

answer: @entity1


abstract: The therapeutic efficacy of @entity2 ( @entity3 ) in chronic @entity1 was evaluated in @entity0 who poorly responded to other antibiotics. To 20 @entity0 , @entity3 was administered 2 g b.i.d. intravenously by drip infusion. Clinical efficacy was judged based on the criteria by score. 1. Bacterial elimination rate with @entity3 was 73.7%. 2. A clinical cure rate was 80.0% was obtained by doctors in charge. 3. According to the score assessment, the overall clinical effectiveness rate was 60.0%, clinical symptom cure rate was 85.0% and improvement rate of X-ray findings was 55.0%. 4. Usefulness rate which was assessed by clinical effect and side effect was 70.0%. 5. No side effects and abnormal laboratory findings were observed in this study. We used the new antibiotic @entity3 in @entity0 with chronic @entity1 who responded poorly to other antibiotics and obtained satisfactory results. Especially @entity3 indicated more effective possibility in cases from whom Gram-negative bacilli was isolated.

title: [Clinical study of XXXX in chronic @entity1 : evaluation in poorly responding cases to other antibiotics (author's transl)].

answer: @entity2


abstract: AIMS: The impact of estimated glomerular filtration rate (eGFR) on adverse events in @entity0 with @entity2 ( @entity2 ) is unknown. We analyzed the independent association of eGFR and @entity4 ( @entity4 ), major @entity3 , and mortality in @entity0 with MHV in an observational cohort study. METHODS AND RESULTS: All @entity0 (n = 520) with MHV replacement on anticoagulation treatment were followed up prospectively regarding @entity4 , major @entity3 , and @entity1 at 2 anticoagulation centers during 2008 to 2011. The mean age was 69 years, 72% with aortic valve replacement, and time in therapeutic range 2.0 to 4.0 was 91%. The incidence of the combined end point of major @entity3 , @entity4 , and @entity1 increased sharply with each decreasing eGFR stratum: 5.5, 8.4, 16, and 32 per 100 @entity0 -years for eGFR >60, 45 to 60, 30 to 45, and <30 mL/min per 1.73 m(2), respectively. After multivariate adjustment for comorbidities, every unit decrease in eGFR increased the risk of major @entity3 by 2%, @entity1 by 3%, and the combined end point by 1%. There was no association between eGFR and @entity4 . There was an increased proportion of international normalized ratio >3.0 and >4.0 and decreasing time in therapeutic range for each decreasing eGFR stratum (P < .001 for trend). The hazard ratios of the combined end point for eGFR <30, 30 to 45, and 45 to 60 mL/min per 1.73 m(2) were 3.2 (95% CI 1.8-5.6), 1.5 (95% CI 0.9-2.5), and 0.9 (95% CI 0.6-1.5), respectively, compared to eGFR >60 mL/min per 1.73 m(2). CONCLUSION: In @entity0 with MHV on anticoagulation, eGFR is an independent predictor of major @entity3 and @entity1 and not @entity4 .

title: Glomerular filtration rate and association to stroke, major @entity3 , and XXXX in @entity0 with mechanical heart valve prosthesis.

answer: @entity1


abstract: AIMS: The impact of estimated glomerular filtration rate (eGFR) on adverse events in @entity0 with @entity2 ( @entity2 ) is unknown. We analyzed the independent association of eGFR and @entity4 ( @entity4 ), major @entity3 , and mortality in @entity0 with MHV in an observational cohort study. METHODS AND RESULTS: All @entity0 (n = 520) with MHV replacement on anticoagulation treatment were followed up prospectively regarding @entity4 , major @entity3 , and @entity1 at 2 anticoagulation centers during 2008 to 2011. The mean age was 69 years, 72% with aortic valve replacement, and time in therapeutic range 2.0 to 4.0 was 91%. The incidence of the combined end point of major @entity3 , @entity4 , and @entity1 increased sharply with each decreasing eGFR stratum: 5.5, 8.4, 16, and 32 per 100 @entity0 -years for eGFR >60, 45 to 60, 30 to 45, and <30 mL/min per 1.73 m(2), respectively. After multivariate adjustment for comorbidities, every unit decrease in eGFR increased the risk of major @entity3 by 2%, @entity1 by 3%, and the combined end point by 1%. There was no association between eGFR and @entity4 . There was an increased proportion of international normalized ratio >3.0 and >4.0 and decreasing time in therapeutic range for each decreasing eGFR stratum (P < .001 for trend). The hazard ratios of the combined end point for eGFR <30, 30 to 45, and 45 to 60 mL/min per 1.73 m(2) were 3.2 (95% CI 1.8-5.6), 1.5 (95% CI 0.9-2.5), and 0.9 (95% CI 0.6-1.5), respectively, compared to eGFR >60 mL/min per 1.73 m(2). CONCLUSION: In @entity0 with MHV on anticoagulation, eGFR is an independent predictor of major @entity3 and @entity1 and not @entity4 .

title: Glomerular filtration rate and association to stroke, major XXXX , and @entity1 in @entity0 with mechanical heart valve prosthesis.

answer: @entity3


abstract: AIMS: The impact of estimated glomerular filtration rate (eGFR) on adverse events in @entity0 with @entity2 ( @entity2 ) is unknown. We analyzed the independent association of eGFR and @entity4 ( @entity4 ), major @entity3 , and mortality in @entity0 with MHV in an observational cohort study. METHODS AND RESULTS: All @entity0 (n = 520) with MHV replacement on anticoagulation treatment were followed up prospectively regarding @entity4 , major @entity3 , and @entity1 at 2 anticoagulation centers during 2008 to 2011. The mean age was 69 years, 72% with aortic valve replacement, and time in therapeutic range 2.0 to 4.0 was 91%. The incidence of the combined end point of major @entity3 , @entity4 , and @entity1 increased sharply with each decreasing eGFR stratum: 5.5, 8.4, 16, and 32 per 100 @entity0 -years for eGFR >60, 45 to 60, 30 to 45, and <30 mL/min per 1.73 m(2), respectively. After multivariate adjustment for comorbidities, every unit decrease in eGFR increased the risk of major @entity3 by 2%, @entity1 by 3%, and the combined end point by 1%. There was no association between eGFR and @entity4 . There was an increased proportion of international normalized ratio >3.0 and >4.0 and decreasing time in therapeutic range for each decreasing eGFR stratum (P < .001 for trend). The hazard ratios of the combined end point for eGFR <30, 30 to 45, and 45 to 60 mL/min per 1.73 m(2) were 3.2 (95% CI 1.8-5.6), 1.5 (95% CI 0.9-2.5), and 0.9 (95% CI 0.6-1.5), respectively, compared to eGFR >60 mL/min per 1.73 m(2). CONCLUSION: In @entity0 with MHV on anticoagulation, eGFR is an independent predictor of major @entity3 and @entity1 and not @entity4 .

title: Glomerular filtration rate and association to stroke, major @entity3 , and @entity1 in XXXX with mechanical heart valve prosthesis.

answer: @entity0


abstract: Systemic @entity2 ( @entity2 ) are classified into @entity3 -positive and @entity3 -negative types. We recently reported that @entity3 -negative @entity2 are genetically heterogenous. The largest subset, representing 30% of cases, had rearrangements of the @entity4 locus. These cases had favorable outcomes similar to @entity3 -positive ALCL, and superior to other @entity3 -negative @entity2 . Here, we examined the morphologic features of these cases in more detail. First, we conducted blinded review of @entity0 and @entity1 slides of 108 @entity2 from our previous study, scoring cases for the presence of 3 histologic patterns and 5 cell types. Cases then were unblinded and re-reviewed to understand these features further. @entity4 -rearranged @entity2 were more likely than other @entity3 -negative @entity2 to have so-called doughnut cells (23% vs. 5%; P=0.039), less likely to have pleomorphic cells (23% vs. 49%; P=0.042), and nearly always (95%) had areas with sheet-like growth (common pattern). To examine the reproducibility of these findings, we conducted blinded review of @entity0 and @entity1 slides of 46 additional @entity3 -negative @entity2 using a 0 to 3 scoring system to predict likelihood of @entity4 rearrangement, the results of which correlated strongly with subsequent findings by fluorescence in situ hybridization (P<0.0001). Although all @entity2 share certain morphologic features, @entity2 with @entity4 rearrangements show significant differences from other @entity3 -negative @entity2 , typically showing sheets of hallmark cells with doughnut cells and few large pleomorphic cells. These morphologic findings and our previous outcome data suggest that @entity3 -positive @entity2 and @entity4 -rearranged @entity2 represent prototypical @entity2 , whereas @entity2 lacking rearrangements of both @entity4 and @entity3 require further study.

title: Morphologic Features of @entity3 -negative Anaplastic Large Cell Lymphomas With XXXX Rearrangements.

answer: @entity4


abstract: Systemic @entity2 ( @entity2 ) are classified into @entity3 -positive and @entity3 -negative types. We recently reported that @entity3 -negative @entity2 are genetically heterogenous. The largest subset, representing 30% of cases, had rearrangements of the @entity4 locus. These cases had favorable outcomes similar to @entity3 -positive ALCL, and superior to other @entity3 -negative @entity2 . Here, we examined the morphologic features of these cases in more detail. First, we conducted blinded review of @entity0 and @entity1 slides of 108 @entity2 from our previous study, scoring cases for the presence of 3 histologic patterns and 5 cell types. Cases then were unblinded and re-reviewed to understand these features further. @entity4 -rearranged @entity2 were more likely than other @entity3 -negative @entity2 to have so-called doughnut cells (23% vs. 5%; P=0.039), less likely to have pleomorphic cells (23% vs. 49%; P=0.042), and nearly always (95%) had areas with sheet-like growth (common pattern). To examine the reproducibility of these findings, we conducted blinded review of @entity0 and @entity1 slides of 46 additional @entity3 -negative @entity2 using a 0 to 3 scoring system to predict likelihood of @entity4 rearrangement, the results of which correlated strongly with subsequent findings by fluorescence in situ hybridization (P<0.0001). Although all @entity2 share certain morphologic features, @entity2 with @entity4 rearrangements show significant differences from other @entity3 -negative @entity2 , typically showing sheets of hallmark cells with doughnut cells and few large pleomorphic cells. These morphologic findings and our previous outcome data suggest that @entity3 -positive @entity2 and @entity4 -rearranged @entity2 represent prototypical @entity2 , whereas @entity2 lacking rearrangements of both @entity4 and @entity3 require further study.

title: Morphologic Features of XXXX -negative Anaplastic Large Cell Lymphomas With @entity4 Rearrangements.

answer: @entity3


abstract: @entity1 at time of diagnosis of @entity11 is very unusual. We here in report 2 pediatric cases of @entity11 who had their renal affection as the first presenting symptom with no evidences of blast cells in blood smear and none of classical presentation of @entity11 . The first case is a 4-year-old @entity0 who presented with @entity12 . Magnetic resonance imaging showed bilateral symmetrical homogenous enlarged kidneys suggestive of infiltration. @entity9 ( @entity9 ) revealed white blood count 11*10   /L, hemoglobin 8.7g/dL and platelet count 197*10   /L. Bone marrow aspiration was performed, and diagnosed precursor B-cell ALL was made. The @entity0 had an excellent response to modified CCG 1991 standard risk protocol of chemotherapy with sustained remission, but unfortunately relapsed 11 month after the end of therapy. The second @entity0 was 13-month old, presented with pallor, @entity2 , abdominal enlargement, and @entity8 2 days before admission. Initial @entity9 showed bicytopenia, elevated blood @entity7 , @entity6 , and serum @entity3 , while abdominal ultrasonography revealed @entity1 . Bone marrow examination was done and showed 92% blast of biphenotypic nature. So, @entity10 with @entity1 and @entity5 was subsequently diagnosed. The @entity0 admitted to ICU and received supportive care and @entity4 . Renal function normalized and chemotherapy was started. The @entity0 achieved complete remission with marked @entity1 but, unfortunately she died from sepsis in consolidation phase of therapy. This case demonstrates an unusual early @entity1 in childhood @entity11 . Renal involvement of @entity11 should be considered in @entity0 presenting with unexplained @entity1 with or without @entity1 and bone marrow examination should be included in the workup.

title: Renal Presentation in Pediatric XXXX : Report of 2 Cases.

answer: @entity11


abstract: INTRODUCTION: It is a common view that consistency and blood supply of @entity2 ( @entity2 ) can influence the surgical effect. The aim of this study was to determine whether MRI signal intensity (SI) was correlated to the consistency or blood supply of @entity4 . METHODS: Forty eight @entity4 @entity0 were underwent preoperative MRI, including precontrast and contrast-enhanced (CE) T1-spin echo (T1-SE) imaging, CE-sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) imaging, and perfusion-weighted imaging (PWI). The @entity1 consistency and blood supply were determined by neurosurgeons. The expression of collagen IV and @entity3 was detected with immunohistology. The correlation of the relative SI (rSI) values ( @entity1 to normal frontal white matter SI) and PWI data to the @entity1 consistency, blood supply, and the expression level of collagen IV and @entity3 was statistically studied by Kruskal-Wallis rank test (K-W test). RESULTS: A significant correlation was observed between the @entity1 consistency and the rSI on precontrast T1-SE imaging (P   =   0.004) but not on CE T1-SE and CE SPACE imaging. The expression of collagen IV was also significantly associated with rSI on T1-SE imaging (P   =   0.010). The blood supply was correlated with the relative CBV (rCBV) (P   =   0.030). In addition, the expression of @entity3 was correlated with rSI of CE T1-SE imaging (P   =   0.007). CONCLUSION: Our results suggest that T1-SE imaging may be a simple and useful method for predicting consistency of @entity2 . CBV value can provide helpful information for assessing the blood supply of @entity4 .

title: Predictive value of PWI for blood supply and T1-spin echo MRI for consistency of XXXX .

answer: @entity2


abstract: The development of new immunomodulatory monoclonal antibodies targeting the @entity6 or @entity8 axis has led to a revival of research on immunotherapies in solid @entity1 including @entity3 ( @entity3 ). The initial results observed with these monoclonal antibodies in the treatment of advanced @entity2 have resulted in considerable interest in this treatment strategy in all @entity1 types. Preliminary data of these new antibodies in advanced @entity3 are promising and they have good safety profiles. Response rates are low but durable @entity1 control has been observed in some @entity0 . However, at the moment there is no evidence that targeting the @entity6 or @entity8 axis provides a substantial clinical benefit compared to established treatment with @entity5 kinase or @entity4 inhibitors. There are also no reliable predictive markers. At the moment, several randomised trials have been initiated to investigate the new immunomodulatory antibodies either as single agents or in combination with anti-VEGF targeted therapy. Vaccines have continued to be investigated in advanced and adjuvant settings. No trial has so far established vaccines as a standard treatment in either situation. There are still large randomised trials ongoing investigating the potential benefit of a vaccine in combination with standard @entity5 kinase inhibitor therapy. In this chapter we will summarise selected studies on immunotherapy in advanced @entity3 with a focus on anti- @entity8 , anti- @entity7 , and anti- @entity6 antibodies. We will also touch briefly on the adjuvant situation and @entity1 vaccines.

title: Immunotherapies in Early and XXXX .

answer: @entity3


abstract: Ninety-two @entity0 who presented for outpatient dental extractions received @entity6 (1.5 mg . kg-1, 46 @entity0 ) or @entity8 (0.3 mg . kg-1, 23 @entity0 and 0.2 mg . kg-1, 23 @entity0 ). The induction characteristics of both drugs such as @entity2 on injection, @entity5 and respiratory difficulties were comparable and the theoretical disadvantages of @entity8 for dental anaesthetics did not prove troublesome in practice. Muscle movements did not interfere with the dentists' manipulations and @entity2 on injection into veins of the antecubital fossa did not occur. The duration of operation for up to four extractions was three minutes and, following induction, anaesthesia was maintained with @entity7 , @entity1 and @entity4 . Recovery was assessed by grading consciousness, airway control and motor activity. All the @entity0 could maintain their airways one minute after the end of operation. The incidence of @entity3 was significantly greater in the @entity8 group.

title: XXXX or @entity8 for induction of dental anaesthesia.

answer: @entity6


abstract: Ninety-two @entity0 who presented for outpatient dental extractions received @entity6 (1.5 mg . kg-1, 46 @entity0 ) or @entity8 (0.3 mg . kg-1, 23 @entity0 and 0.2 mg . kg-1, 23 @entity0 ). The induction characteristics of both drugs such as @entity2 on injection, @entity5 and respiratory difficulties were comparable and the theoretical disadvantages of @entity8 for dental anaesthetics did not prove troublesome in practice. Muscle movements did not interfere with the dentists' manipulations and @entity2 on injection into veins of the antecubital fossa did not occur. The duration of operation for up to four extractions was three minutes and, following induction, anaesthesia was maintained with @entity7 , @entity1 and @entity4 . Recovery was assessed by grading consciousness, airway control and motor activity. All the @entity0 could maintain their airways one minute after the end of operation. The incidence of @entity3 was significantly greater in the @entity8 group.

title: @entity6 or XXXX for induction of dental anaesthesia.

answer: @entity8


abstract: The frequency of @entity2 is increasing and has surpassed that of @entity0 . Lesions are more common in the head of the gland than in the body and tail. @entity0 tend to be localized and are associated with a better prognosis. The majority of @entity0 are hard and demonstrate a prominent @entity4 . They present as ill-defined masses which makes their differentiation from chronic @entity2 difficult. Duct cell @entity1 constitute 75% of all @entity0 of the pancreas. Some of the uncommon types include @entity7 , @entity3 , @entity6 and @entity5 . The role of open biopsy in diagnosing @entity2 remains controversial. Percutaneous fine-needle aspiration cytology appears promising. The technique is safe and inexpensive but needs an experienced cytopathologist to interpret the results accurately.

title: The pathological features of XXXX .

answer: @entity2


abstract: Inasmuch as @entity6 do not occur frequently, a preadolescent or early adolescent @entity0 who has persistent complaints of @entity2 with peroneal or anterior tibial muscle @entity3 warrants special evaluation. The @entity0 may complain of becoming easily tired or report the onset of @entity2 with increased activity. Clinical examination may reveal local tenderness over the area of the coalition, but this is not a consistent finding. Restricted inversion of the foot with @entity3 of the peroneals, forefoot abduction or pronation should alert the examining physician that a @entity5 may be present. Appropriate roentgenograms examining all of the possibly involved joints should be obtained. These include 45 degrees oblique views of the foot, which usually give a satisfactory view of the @entity4 joint. Coalitions may occur in any of the facets of the talocalcaneal joint and therefore all facets must be evaluated. The anatomic location of the facets can be variable and multiple-angle axial views may be required. We recommend a 45 degrees axial view to visualize the posterior and middle facets, since they are normally parallel in the axial view. If @entity1 are present, the middle facet may be oblique. Tomography is necessary to visualize the anterior facet or to confirm a coalition either in the middle or in the posterior facets.

title: XXXX : review of the literature and case report of bilateral dual @entity4 and @entity6 .

answer: @entity5


abstract: Inasmuch as @entity6 do not occur frequently, a preadolescent or early adolescent @entity0 who has persistent complaints of @entity2 with peroneal or anterior tibial muscle @entity3 warrants special evaluation. The @entity0 may complain of becoming easily tired or report the onset of @entity2 with increased activity. Clinical examination may reveal local tenderness over the area of the coalition, but this is not a consistent finding. Restricted inversion of the foot with @entity3 of the peroneals, forefoot abduction or pronation should alert the examining physician that a @entity5 may be present. Appropriate roentgenograms examining all of the possibly involved joints should be obtained. These include 45 degrees oblique views of the foot, which usually give a satisfactory view of the @entity4 joint. Coalitions may occur in any of the facets of the talocalcaneal joint and therefore all facets must be evaluated. The anatomic location of the facets can be variable and multiple-angle axial views may be required. We recommend a 45 degrees axial view to visualize the posterior and middle facets, since they are normally parallel in the axial view. If @entity1 are present, the middle facet may be oblique. Tomography is necessary to visualize the anterior facet or to confirm a coalition either in the middle or in the posterior facets.

title: @entity5 : review of the literature and case report of bilateral dual @entity4 and XXXX .

answer: @entity6


abstract: Inasmuch as @entity6 do not occur frequently, a preadolescent or early adolescent @entity0 who has persistent complaints of @entity2 with peroneal or anterior tibial muscle @entity3 warrants special evaluation. The @entity0 may complain of becoming easily tired or report the onset of @entity2 with increased activity. Clinical examination may reveal local tenderness over the area of the coalition, but this is not a consistent finding. Restricted inversion of the foot with @entity3 of the peroneals, forefoot abduction or pronation should alert the examining physician that a @entity5 may be present. Appropriate roentgenograms examining all of the possibly involved joints should be obtained. These include 45 degrees oblique views of the foot, which usually give a satisfactory view of the @entity4 joint. Coalitions may occur in any of the facets of the talocalcaneal joint and therefore all facets must be evaluated. The anatomic location of the facets can be variable and multiple-angle axial views may be required. We recommend a 45 degrees axial view to visualize the posterior and middle facets, since they are normally parallel in the axial view. If @entity1 are present, the middle facet may be oblique. Tomography is necessary to visualize the anterior facet or to confirm a coalition either in the middle or in the posterior facets.

title: @entity5 : review of the literature and case report of bilateral dual XXXX and @entity6 .

answer: @entity4


abstract: Two-dimensional echocardiographic studies have shown that maximum long-axis systolic aortic cusp separation (MACS) represents a useful, noninvasive method for estimating severity of @entity1 in adults. Although mean values for @entity0 with mild, moderate, and severe @entity2 have been clearly separated by this method, overlap occurs among individual @entity0 . In this study, 81 adults with @entity2 were studied by two-dimensional echocardiography in the long-axis view. Long-axis assessment of @entity2 was obtainable in 93 percent of the @entity0 . Less than 8-mm separation was 97 percent predictive of severe @entity3 and 100 percent predictive of moderate or severe @entity3 . Eight- to 12-mm had a low predictive value for the severity of @entity3 . Greater than 12-mm separation was 96 percent predictive of mild @entity2 . @entity4 scans were attempted in 61 of the 81 subjects. Short axis assessment of @entity2 based on patterns of leaflet motion was obtainable in 46 of the 61 @entity0 (73 percent) and provided a valuable index of severity. When @entity4 scans were included in the assessment of severity in the subgroup of @entity0 with 8- to 12-mm MACS, the predictive value improved greatly (86 percent vs 46 percent). Direct recording of aortic valve area in @entity4 was successful in only 13 percent of the subjects. The echo aortic valve area compared with the hemodynamic calculated aortic valve area yielded an r = 0.87.

title: Reliability of two-dimensional echocardiography in assessing the severity of XXXX .

answer: @entity1


abstract: UNASSIGNED: Cancer stem cell (CSC) markers could serve as potential prognostic procedure. This study is aimed to investigate the local expression of @entity3 ( @entity3 ) and @entity4 in @entity2 ( @entity2 ) at both protein and messenger RNA (mRNA) level, followed by providing a comparison of the local and circulating expression pattern of these markers, based on our present and previous study. The mRNA expression level of @entity3 and @entity4 was evaluated using comparative real-time PCR method applying 58 fresh @entity1 tissues and their correspondent normal margins. Immunohistochemistry was applied to analyze the protein expression level of @entity3 and @entity4 in paraffin-embedded @entity2 tissues. The correlation of @entity3 and @entity4 expression pattern with clinicopathological characteristics was assessed. A higher mRNA expression level of @entity3 (3.28-fold change, p   <   0.001) and @entity4 (2.29-fold change, p   <   0.001) was observed in @entity2 fresh tissues compared to the normal adjacent margins, and the expression level was higher in @entity0 with higher grade and stages of disease and @entity0 who underwent neoadjuvant chemoradiotherapy (CRT). The protein expression level of @entity3 and @entity4 was also increased significantly in @entity1 tissues compared to normal colon tissues which were positively correlated to @entity1 stage and grade and neoadjuvant CRT. Taken together, the results of protein analysis were in accordance with mRNA assessment. The local expression pattern of @entity3 and @entity4 was also in accordance with their expression level in circulation. However, some minor inconsistencies were observed which may be attributed to several factors including the possible effect of CRT on CSC reprogramming.

title: A new insight into @entity1 stem cell markers: Could local and circulating @entity1 stem cell markers correlate in XXXX ?

answer: @entity2


abstract: UNASSIGNED: Cancer stem cell (CSC) markers could serve as potential prognostic procedure. This study is aimed to investigate the local expression of @entity3 ( @entity3 ) and @entity4 in @entity2 ( @entity2 ) at both protein and messenger RNA (mRNA) level, followed by providing a comparison of the local and circulating expression pattern of these markers, based on our present and previous study. The mRNA expression level of @entity3 and @entity4 was evaluated using comparative real-time PCR method applying 58 fresh @entity1 tissues and their correspondent normal margins. Immunohistochemistry was applied to analyze the protein expression level of @entity3 and @entity4 in paraffin-embedded @entity2 tissues. The correlation of @entity3 and @entity4 expression pattern with clinicopathological characteristics was assessed. A higher mRNA expression level of @entity3 (3.28-fold change, p   <   0.001) and @entity4 (2.29-fold change, p   <   0.001) was observed in @entity2 fresh tissues compared to the normal adjacent margins, and the expression level was higher in @entity0 with higher grade and stages of disease and @entity0 who underwent neoadjuvant chemoradiotherapy (CRT). The protein expression level of @entity3 and @entity4 was also increased significantly in @entity1 tissues compared to normal colon tissues which were positively correlated to @entity1 stage and grade and neoadjuvant CRT. Taken together, the results of protein analysis were in accordance with mRNA assessment. The local expression pattern of @entity3 and @entity4 was also in accordance with their expression level in circulation. However, some minor inconsistencies were observed which may be attributed to several factors including the possible effect of CRT on CSC reprogramming.

title: A new insight into XXXX stem cell markers: Could local and circulating @entity1 stem cell markers correlate in @entity2 ?

answer: @entity1


abstract: UNASSIGNED: Cancer stem cell (CSC) markers could serve as potential prognostic procedure. This study is aimed to investigate the local expression of @entity3 ( @entity3 ) and @entity4 in @entity2 ( @entity2 ) at both protein and messenger RNA (mRNA) level, followed by providing a comparison of the local and circulating expression pattern of these markers, based on our present and previous study. The mRNA expression level of @entity3 and @entity4 was evaluated using comparative real-time PCR method applying 58 fresh @entity1 tissues and their correspondent normal margins. Immunohistochemistry was applied to analyze the protein expression level of @entity3 and @entity4 in paraffin-embedded @entity2 tissues. The correlation of @entity3 and @entity4 expression pattern with clinicopathological characteristics was assessed. A higher mRNA expression level of @entity3 (3.28-fold change, p   <   0.001) and @entity4 (2.29-fold change, p   <   0.001) was observed in @entity2 fresh tissues compared to the normal adjacent margins, and the expression level was higher in @entity0 with higher grade and stages of disease and @entity0 who underwent neoadjuvant chemoradiotherapy (CRT). The protein expression level of @entity3 and @entity4 was also increased significantly in @entity1 tissues compared to normal colon tissues which were positively correlated to @entity1 stage and grade and neoadjuvant CRT. Taken together, the results of protein analysis were in accordance with mRNA assessment. The local expression pattern of @entity3 and @entity4 was also in accordance with their expression level in circulation. However, some minor inconsistencies were observed which may be attributed to several factors including the possible effect of CRT on CSC reprogramming.

title: A new insight into @entity1 stem cell markers: Could local and circulating XXXX stem cell markers correlate in @entity2 ?

answer: @entity1


abstract: We have studied the effect of T4 itself (i.e. without extrapituitary conversion to T3) on the feedback regulation of pituitary TSH secretion in thyroidectomized @entity0 receiving continuous T4 or T3 replacement. Continuous sc infusion of 1.0 or 2.0 microgram T4/100 g . day in 0.01 N @entity3 , 20% @entity2 vehicle failed to maintain the plasma T4 concentration in thyroidectomized @entity0 for more than 48 h, despite the verification of T4 delivery. Continuous sc infusion of 1.0 or 2.0 microgram T4/100 g . day in 0.01 N @entity3 , 5% rat serum resulted in a dose-dependent elevation in the plasma T4 concentration and inhibition of the postthyroidectomy rise in plasma TSH, in the presence of low plasma T3 concentrations. Mimicking the low plasma T3 concentrations that resulted from T4 infusion by continuous replacement of 280 ng T3/100 g . day failed to inhibit the postthyroidectomy rise in plasma TSH. The pituitary responsiveness to @entity1 (250 ng/100 g, iv) after 96 h of thyroid hormone infusion was significantly (P less than 0.05) inhibited only in the group receiving 2.0 microgram T4/100 g . day. These results indicate that the plasma T4, concentration in addition to that of plasma T3, conveys feedback information to the pituitary. With regard to pituitary TSH secretion, T4 acts as both a prohormone giving rise to a protion of the plasma T3 by peripheral monodeiodination and as a hormone conveying feedback information via the blood to the pituitary.

title: Effect of continuous thyroxine administration on thyrotropin secretion in thyroidectomized XXXX .

answer: @entity0


abstract: The criteria that are used at present to diagnose @entity1 's milk protein sensitive enteropathy (CMPSE) are based on an in vivo milk challenge which can be hazardous and life threatening. We have used an organ culture model to determine the usefulness of this technique in establishing the diagnosis of CMPSE on the basis of a single biopsy with in vitro milk challenge. Fourteen @entity0 with @entity2 clinically suspected to have CMPSE were studied prospectively. On the basis of milk challenge studies seven @entity0 had CMPSE. They had clinical reaction to @entity1 's milk with associated histological changes and depression of alkaline phosphatase levels in the jejunal mucosa. In all seven cases parallel changes in alkaline phosphatase levels were noted in the organ culture specimens of initial biopsy subjected to in vitro challenge. The seven control @entity0 tolerated @entity1 's milk and did not have histological changes. The alkaline phosphatase levels were moderately increased in the jejunal mucosa in five of the seven @entity0 . The alkaline phosphatase levels in the organ culture specimens of initial biopsy were increased after in vitro challenge in all seven @entity0 . This study suggests that organ culture methods may be useful in the vitro diagnosis of CMPSE, and also obviate the need for in vivo oral milk challenges and repeated biopsies.

title: In vitro diagnosis of XXXX 's milk protein sensitive enteropathy by organ culture method.

answer: @entity1


abstract: The association of @entity6 and @entity3 has been reported in @entity4 and, more rarely, in other forms of @entity2 . The prevalence of @entity3 and its relationship to @entity6 is unknown. In this prospective study, we have determined the prevalence of @entity3 and @entity6 in 74 @entity0 with @entity4 and 54 with other forms of @entity2 . Clubbing was present in 24% of @entity0 with @entity4 , 29% with HBsAg negative @entity5 , and 23% in the group of miscellaneous @entity2 . Symmetrical @entity3 affecting the tibiae and fibulae occurred in 35% of @entity0 with @entity4 , 29% with chronic, active @entity1 and 40% of @entity0 in the miscellaneous group. The distal radii and ulnae were affected in only eight @entity0 (6%). In @entity4 , the presence of @entity6 was strongly associated with @entity3 (P less than 0.01), but this association was uncommon in other forms of @entity2 . In all forms of @entity2 @entity3 commonly occurs in the absence of @entity6 . Marked tenderness over the distal leg bones is a reliable sign of underlying @entity3 , but this sign is present in only a third of affected @entity0 . This study indicates that @entity3 affecting the lower leg bones is common in @entity0 with @entity2 , and its presence should be sought whether or not the @entity0 has @entity6 .

title: Prospective study of @entity3 and @entity6 in @entity4 and other forms of XXXX .

answer: @entity2


abstract: The association of @entity6 and @entity3 has been reported in @entity4 and, more rarely, in other forms of @entity2 . The prevalence of @entity3 and its relationship to @entity6 is unknown. In this prospective study, we have determined the prevalence of @entity3 and @entity6 in 74 @entity0 with @entity4 and 54 with other forms of @entity2 . Clubbing was present in 24% of @entity0 with @entity4 , 29% with HBsAg negative @entity5 , and 23% in the group of miscellaneous @entity2 . Symmetrical @entity3 affecting the tibiae and fibulae occurred in 35% of @entity0 with @entity4 , 29% with chronic, active @entity1 and 40% of @entity0 in the miscellaneous group. The distal radii and ulnae were affected in only eight @entity0 (6%). In @entity4 , the presence of @entity6 was strongly associated with @entity3 (P less than 0.01), but this association was uncommon in other forms of @entity2 . In all forms of @entity2 @entity3 commonly occurs in the absence of @entity6 . Marked tenderness over the distal leg bones is a reliable sign of underlying @entity3 , but this sign is present in only a third of affected @entity0 . This study indicates that @entity3 affecting the lower leg bones is common in @entity0 with @entity2 , and its presence should be sought whether or not the @entity0 has @entity6 .

title: Prospective study of @entity3 and XXXX in @entity4 and other forms of @entity2 .

answer: @entity6


abstract: The association of @entity6 and @entity3 has been reported in @entity4 and, more rarely, in other forms of @entity2 . The prevalence of @entity3 and its relationship to @entity6 is unknown. In this prospective study, we have determined the prevalence of @entity3 and @entity6 in 74 @entity0 with @entity4 and 54 with other forms of @entity2 . Clubbing was present in 24% of @entity0 with @entity4 , 29% with HBsAg negative @entity5 , and 23% in the group of miscellaneous @entity2 . Symmetrical @entity3 affecting the tibiae and fibulae occurred in 35% of @entity0 with @entity4 , 29% with chronic, active @entity1 and 40% of @entity0 in the miscellaneous group. The distal radii and ulnae were affected in only eight @entity0 (6%). In @entity4 , the presence of @entity6 was strongly associated with @entity3 (P less than 0.01), but this association was uncommon in other forms of @entity2 . In all forms of @entity2 @entity3 commonly occurs in the absence of @entity6 . Marked tenderness over the distal leg bones is a reliable sign of underlying @entity3 , but this sign is present in only a third of affected @entity0 . This study indicates that @entity3 affecting the lower leg bones is common in @entity0 with @entity2 , and its presence should be sought whether or not the @entity0 has @entity6 .

title: Prospective study of XXXX and @entity6 in @entity4 and other forms of @entity2 .

answer: @entity3


abstract: The association of @entity6 and @entity3 has been reported in @entity4 and, more rarely, in other forms of @entity2 . The prevalence of @entity3 and its relationship to @entity6 is unknown. In this prospective study, we have determined the prevalence of @entity3 and @entity6 in 74 @entity0 with @entity4 and 54 with other forms of @entity2 . Clubbing was present in 24% of @entity0 with @entity4 , 29% with HBsAg negative @entity5 , and 23% in the group of miscellaneous @entity2 . Symmetrical @entity3 affecting the tibiae and fibulae occurred in 35% of @entity0 with @entity4 , 29% with chronic, active @entity1 and 40% of @entity0 in the miscellaneous group. The distal radii and ulnae were affected in only eight @entity0 (6%). In @entity4 , the presence of @entity6 was strongly associated with @entity3 (P less than 0.01), but this association was uncommon in other forms of @entity2 . In all forms of @entity2 @entity3 commonly occurs in the absence of @entity6 . Marked tenderness over the distal leg bones is a reliable sign of underlying @entity3 , but this sign is present in only a third of affected @entity0 . This study indicates that @entity3 affecting the lower leg bones is common in @entity0 with @entity2 , and its presence should be sought whether or not the @entity0 has @entity6 .

title: Prospective study of @entity3 and @entity6 in XXXX and other forms of @entity2 .

answer: @entity4


abstract: @entity0 delta-toxin bound avidly to agarose gels containing @entity9 , @entity12 , or @entity6 ligands, but less so to agarose with @entity11 groups. @entity4 with @entity10 or @entity7 moieties did not bind any more toxin than did agarose without attached ligands. About 10% of the applied toxin preparation did not bind to gels and eluted with the starting buffer. The nonadsorbed material was not hemolytic, did not react with anti-delta-toxin immunoglobulin G, and did not appear to be a peptide. Toxin bound to @entity5 was not eluted with water, solutions containing chaotropic ions or @entity8 , or by increasing the pH, but was eluted with 50% @entity2 . The @entity2 -eluted delta-toxin (EEDT) was soluble in water, @entity2 , 10% @entity1 , or 6 M @entity3 , but was poorly soluble in aqueous salt solutions at neutral pH. Regardless of whether the soluble or insoluble form of delta-toxin was applied to the gel, the resultant EEDT fraction was water soluble. The hemolytic activity of EEDT was markedly reduced when assayed in saline, but was the same as that of the original toxin preparation when assayed in isotonic @entity1 . A significant portion of EEDT, when rechromatographed on @entity5 , did not bind to the gel. This unbound fraction may represent toxin aggregates in which the hydrophobic regions of the toxin monomers are interiorized within the aggregates.

title: Hydrophobic interaction chromatography of XXXX delta-toxin.

answer: @entity0


abstract: The effect of @entity1 ( @entity2 ) on the aquarium fish, Lebistes reticulatus (guppy) has been investigated. The aquarium water contained 10 to 200 parts per million of NDEA. The LC50/30 for NDEA was 100 ppm. Sub-chronic experiments were carried out using 25 and 50 ppm for 90 days. The liver alterations were investigated morphologically. Initially, @entity0 of hepatic cells, disorientation of hepatic structure and cyst-formation appeared. The @entity4 were followed by multiple foci of regenerating hepatic cells. In the later period of the experiment, hyperplastic nodules of hepatocytes, cholangiofibrosis, @entity5 , @entity3 could be observed in the treated animals. The following conclusions have been reached: 1. Aquarium fish can be used as a model for short-term, in vivo carcinogenesis experiments. 2. Lebistes reticulatus is a suitable strain for use as a positive control with NDEA. 3. With this model, the process of carcinogenesis can be followed histologically. 4. The process is irreversible and some of its features may be used as an early indicator in the screening of possible carcinogenic substances.

title: Hepatic lesions in Lebistes reticulatus induced by XXXX .

answer: @entity1


abstract: @entity4 is a common gynecological condition which usually presents with symptoms of acute abdomen. During the period 1976 to 1978, 152 cases of ectopic pregnancy were treated in our department. About one ectopic pregnancy was treated for every 100 @entity0 delivered. Most of the cases were seen during summer time. Of the @entity0 43% were between 26 to 30 years of age. From their previous history, 47% reported one or more terminations of pregnancy and 33% recurrence of @entity1 . The majority of the ectopic pregnancies were located in the tube. Abdominal pregnancy was observed in three @entity0 , one of whom delivered, with the aid of laparotomy, a live @entity0 . All the @entity0 reported @entity3 , whereas @entity2 appeared in only 23% of the cases. Culdocentesis gave false negative results in 14.15% of the cases. Preoperative diagnosis was based on laparoscopy in 28 cases. Dilatation and curettage (D and C) with endometrial biopsy disclosed decidual endometrium without chorionic villi in 37% and @entity5 cells in 68% of cases. Salpingectomy was performed in 52% of the cases, and plastic surgery of the tube in 16%.

title: XXXX : outcome of 152 cases.

answer: @entity4