abstract: @entity1 synthetase was isolated from the Harderian gland of @entity0 . The @entity2 synthesized by the purified enzyme were analyzed by mass fragmentography. The purified enzyme had an inherent capacity to utilize @entity4 and synthesize @entity5 . Physicochemical studies indicated that an active enzyme was a dimer, consisted of two subunits of Mr = 2.5 X 10(5). The negatively stained enzyme had an electron micrographic image of an ellipsoidal contour with a continuous middle cleft along the major @entity3 . The major and minor axes were approximately equal to 220 and 150 A, respectively. In a dimer, the subunit had a rod-like structure about 220 A long and 50 A wide. The enzyme was inactivated and dissociated into subunits by incubation at 0 degree C. The inactivated enzyme was fully reactivated by raising the temperature of the solution. The relationship between the quaternary structure of the enzyme and the occurrence of enzymatic activity was studied by high-performance liquid chromatography. Neither active monomers nor inactive dimers were found in inactivation and reactivation processes. The initial velocity of reactivation was proportional to the enzyme concentration over a concentration range of 160-800 micrograms/ml, indicating that the rate-determining step in the reactivation reaction was unimolecular.

title: The quaternary structure and activity of newly purified XXXX synthetase from the Harderian gland of @entity0 .

answer: @entity1


abstract: @entity1 synthetase was isolated from the Harderian gland of @entity0 . The @entity2 synthesized by the purified enzyme were analyzed by mass fragmentography. The purified enzyme had an inherent capacity to utilize @entity4 and synthesize @entity5 . Physicochemical studies indicated that an active enzyme was a dimer, consisted of two subunits of Mr = 2.5 X 10(5). The negatively stained enzyme had an electron micrographic image of an ellipsoidal contour with a continuous middle cleft along the major @entity3 . The major and minor axes were approximately equal to 220 and 150 A, respectively. In a dimer, the subunit had a rod-like structure about 220 A long and 50 A wide. The enzyme was inactivated and dissociated into subunits by incubation at 0 degree C. The inactivated enzyme was fully reactivated by raising the temperature of the solution. The relationship between the quaternary structure of the enzyme and the occurrence of enzymatic activity was studied by high-performance liquid chromatography. Neither active monomers nor inactive dimers were found in inactivation and reactivation processes. The initial velocity of reactivation was proportional to the enzyme concentration over a concentration range of 160-800 micrograms/ml, indicating that the rate-determining step in the reactivation reaction was unimolecular.

title: The quaternary structure and activity of newly purified @entity1 synthetase from the Harderian gland of XXXX .

answer: @entity0


abstract: BACKGROUND: Routine performance of thoraco-lumbar (TL) spinal radiology in @entity0 with blunt @entity1 is controversial. @entity0 AND METHODS: To establish indications for radiologic screening of the TL spine, a retrospective review of 344 @entity0 who had radiologic evaluation of the spine was performed. RESULTS: Forty-seven @entity0 had abnormalities detected on radiologic evaluation. One hundred eighty-six @entity0 had at least one clinical finding suggestive of injury. Thirty-two had abnormal radiographs. Thirteen of these abnormalities represented old or minor @entity2 and were not treated. Nineteen @entity0 had injuries requiring treatment. Two @entity0 were treated with activity restriction, 12 with a back brace, 4 with operative fixation, and 1 @entity0 died prior to operation. Of the 129 @entity0 who were awake, alert, and without clinical evidence of injury, 10 had abnormal radiologic studies. Three @entity0 had old @entity2 , 4 had transverse process @entity2 , and 3 had spondylolisthesis. None of these @entity0 required treatment. Twenty-nine @entity0 had equivocal clinical examinations primarily due to altered levels of consciousness. Five @entity0 had abnormal radiologic studies, 3 of whom required treatment. Three factors associated with the occurrence of TL spine injury were identified: an Injury Severity Score > or = 15, a positive clinical examination, and a fall of > or = 10 feet. CONCLUSIONS: These data suggest that @entity0 who are awake, alert, and with no clinical evidence of injury do not require radiologic study of the TL spine. @entity0 with equivocal or positive clinical findings or with altered levels of consciousness should have complete TL spine evaluation.

title: Evaluation of the thoracic and lumbar spine after blunt XXXX .

answer: @entity1


abstract: The relationship between the active @entity0 -binding function of the cardiac sarcoplasmic reticulum (SR) and left ventricular (LV) relaxation was studied in various stages of chronically volume overloading @entity1 hearts induced by complete atrio-ventricular (A-V) block. Rapid kinetic measurement of the @entity0 -binding activity of SR was made using a dual-beam spectrophotometric assay procedure. LV hemodynamics, especially diastolic indexes, were evaluated by the pressure-volume relationship using a trans-epicardial echo-cardiographic technique. In this study the maximum @entity0 -binding capacity and the initial @entity0 -binding rate of SR were impaired in @entity6 and failing hearts induced by @entity7 . However, there was no significant difference of SR functional defect between the hypertrophied and the failing hearts. LV systolic properties were not influenced even by chronic @entity7 . Its diastolic properties, however, were reduced with the progress of @entity5 , and were estimated to respond more sensitively to the @entity2 compared with systolic properties. There was a close interrelation between the @entity0 -binding activity of SR on the molecular level and diastolic parameters, especially the time constant T, on the ventricular chamber level. In conclusion, the impairment of the @entity0 -binding activity of SR is a cause of @entity3 of LV diastole. However, the role of SR in the occurrence of @entity4 could not be clarified in this study.

title: Calcium-binding of cardiac sarcoplasmic reticulum and diastolic hemodynamics in volume overloaded XXXX hearts.

answer: @entity1


abstract: The effect of aniso-osmotic exposure on the level of inducible cyclooxygenase ( @entity14 ) and on prostanoid synthesis was studied in cultured @entity0 liver macrophages (Kupffer cells). In lipopolysaccharide (LPS)- or @entity4 -stimulated Kupffer cells, hyperosmotic (355 mosmol/l) exposure, due to addition of @entity3 or impermeant @entity11 , markedly increased @entity9 (PG) E2, D2 and @entity15 synthesis in a time- and osmolarity-dependent manner. Increased prostanoid production was observed about 8 h after exposure to LPS in hyperosmotic medium compared to Kupffer cells treated with LPS under normotonic (305 mosmol/l) conditions. A similar stimulatory effect of @entity6 on @entity5 production was also seen when @entity12 was added exogenously. Hyperosmotic stimulation of @entity5 production was accompanied by a strong induction of @entity14 mRNA levels and an increase in immunoreactive @entity14 , whereas the levels of immunoreactive phospholipase A2 and @entity18 did not change significantly. @entity2 , @entity10 and the selective @entity14 inhibitor, @entity16 , abolished the hypertonicity-induced stimulation of @entity5 formation; @entity2 also prevented the increase in @entity14 mRNA and protein. The increase of immunoreactive @entity14 lasted for about 24 h and was also blocked by @entity13 or @entity7 , but not by @entity17 . @entity8 or treatment with endoglucosidase H reduced the molecular mass of hypertonicity-induced @entity14 by 5 kDa. @entity8 treatment also suppressed the hypertonicity-induced stimulation of @entity5 production. The @entity6 /LPS-induced stimulation of @entity9 formation was partly sensitive to protein kinase C inhibition but was not accompanied by an increase in the cytosolic free @entity1 concentration. The data suggest that osmolarity may be a critical factor in the regulation of @entity14 expression and prostanoid production in activated @entity0 liver macrophages.

title: XXXX stimulates @entity9 synthesis and cyclooxygenase-2 expression in activated @entity0 liver macrophages.

answer: @entity6


abstract: The effect of aniso-osmotic exposure on the level of inducible cyclooxygenase ( @entity14 ) and on prostanoid synthesis was studied in cultured @entity0 liver macrophages (Kupffer cells). In lipopolysaccharide (LPS)- or @entity4 -stimulated Kupffer cells, hyperosmotic (355 mosmol/l) exposure, due to addition of @entity3 or impermeant @entity11 , markedly increased @entity9 (PG) E2, D2 and @entity15 synthesis in a time- and osmolarity-dependent manner. Increased prostanoid production was observed about 8 h after exposure to LPS in hyperosmotic medium compared to Kupffer cells treated with LPS under normotonic (305 mosmol/l) conditions. A similar stimulatory effect of @entity6 on @entity5 production was also seen when @entity12 was added exogenously. Hyperosmotic stimulation of @entity5 production was accompanied by a strong induction of @entity14 mRNA levels and an increase in immunoreactive @entity14 , whereas the levels of immunoreactive phospholipase A2 and @entity18 did not change significantly. @entity2 , @entity10 and the selective @entity14 inhibitor, @entity16 , abolished the hypertonicity-induced stimulation of @entity5 formation; @entity2 also prevented the increase in @entity14 mRNA and protein. The increase of immunoreactive @entity14 lasted for about 24 h and was also blocked by @entity13 or @entity7 , but not by @entity17 . @entity8 or treatment with endoglucosidase H reduced the molecular mass of hypertonicity-induced @entity14 by 5 kDa. @entity8 treatment also suppressed the hypertonicity-induced stimulation of @entity5 production. The @entity6 /LPS-induced stimulation of @entity9 formation was partly sensitive to protein kinase C inhibition but was not accompanied by an increase in the cytosolic free @entity1 concentration. The data suggest that osmolarity may be a critical factor in the regulation of @entity14 expression and prostanoid production in activated @entity0 liver macrophages.

title: @entity6 stimulates XXXX synthesis and cyclooxygenase-2 expression in activated @entity0 liver macrophages.

answer: @entity9


abstract: The effect of aniso-osmotic exposure on the level of inducible cyclooxygenase ( @entity14 ) and on prostanoid synthesis was studied in cultured @entity0 liver macrophages (Kupffer cells). In lipopolysaccharide (LPS)- or @entity4 -stimulated Kupffer cells, hyperosmotic (355 mosmol/l) exposure, due to addition of @entity3 or impermeant @entity11 , markedly increased @entity9 (PG) E2, D2 and @entity15 synthesis in a time- and osmolarity-dependent manner. Increased prostanoid production was observed about 8 h after exposure to LPS in hyperosmotic medium compared to Kupffer cells treated with LPS under normotonic (305 mosmol/l) conditions. A similar stimulatory effect of @entity6 on @entity5 production was also seen when @entity12 was added exogenously. Hyperosmotic stimulation of @entity5 production was accompanied by a strong induction of @entity14 mRNA levels and an increase in immunoreactive @entity14 , whereas the levels of immunoreactive phospholipase A2 and @entity18 did not change significantly. @entity2 , @entity10 and the selective @entity14 inhibitor, @entity16 , abolished the hypertonicity-induced stimulation of @entity5 formation; @entity2 also prevented the increase in @entity14 mRNA and protein. The increase of immunoreactive @entity14 lasted for about 24 h and was also blocked by @entity13 or @entity7 , but not by @entity17 . @entity8 or treatment with endoglucosidase H reduced the molecular mass of hypertonicity-induced @entity14 by 5 kDa. @entity8 treatment also suppressed the hypertonicity-induced stimulation of @entity5 production. The @entity6 /LPS-induced stimulation of @entity9 formation was partly sensitive to protein kinase C inhibition but was not accompanied by an increase in the cytosolic free @entity1 concentration. The data suggest that osmolarity may be a critical factor in the regulation of @entity14 expression and prostanoid production in activated @entity0 liver macrophages.

title: @entity6 stimulates @entity9 synthesis and cyclooxygenase-2 expression in activated XXXX liver macrophages.

answer: @entity0


abstract: Records of 231 @entity0 (171 males, 60 females; aged 10 months to 83 years [median 45 years]) who underwent operation for @entity8 at the Mayo Clinic from 1936 through 1982 were reviewed. All had had hemodynamically significant pericardial constriction preoperatively, and @entity2 was confirmed at operation. Preoperatively, 69% were in New York Heart Association Class III or IV and 81% had peripheral @entity1 or @entity6 . Pericardiectomy was performed through a left anterolateral thoracotomy (34%), a median sternotomy (27%), a U incision (Harrington) (21%), or a bilateral anterior thoracotomy (18%). Postoperatively, 28% of @entity0 had evidence of @entity7 ; 70% of the 32 @entity3 within 30 days of operation were due to @entity7 . Operative risk was significantly (p less than 0.001) related to @entity5 (1% for Class I or II; 10% for class III; 46% for Class IV). Median postoperative follow-up was 9 years (longest was 43 years). Probability of survival for @entity0 dismissed alive from the hospital was 84% at 5 years, 71% at 15 years, and 52% at 30 years. Long-term survival (excluding operative mortality) was not significantly influenced by the disability class preoperatively, the operative approach, or the development of @entity7 in the immediate postoperative period. At the end of the follow-up interval, there were 141 @entity0 in whom functional capacity could be assessed; 140 were in Class I or II. We conclude that a poor hemodynamic result after complete pericardiectomy relates to the preoperative degree of constriction and resultant @entity4 . We recommend early pericardiectomy when pericardial constriction is diagnosed, and we continue to use a left anterolateral thoracotomy as the preferred approach for most @entity0 .

title: Early and late results of pericardiectomy for XXXX .

answer: @entity8


abstract: INTRODUCTION: @entity3 in @entity1 is a common problem, requiring stoma placement to decompress the colon and permit neo-adjuvant treatment. The majority of @entity0 operated on in our hospital are referred; after stoma placement at the referring centre without overseeing final type of surgery. Stoma malpositioning and its effects on @entity1 care are described. METHODS: All @entity0 who underwent surgery for locally advanced or locally recurrent @entity1 between 2000 and 2013 in our tertiary referral centre were reviewed and included if they received a stoma before curative surgery. @entity0 with recurrent @entity1 were only included if the stomas from the primary surgery had been restored. The main outcome measures are stoma malpositioning, postoperative and @entity2 . RESULTS: A total of 726 @entity0 were included; of these, 156 @entity0 (21%) had a stoma before curative surgery. In the majority of @entity0 , acute or pending @entity3 was the main indication for emergent stoma creation; some of the @entity0 had @entity1 -related fistulae. In 53 @entity0 (34%), the stoma required revision during definitive surgery. No significant differences were found regarding postoperative complications. CONCLUSION: One-third of the previously placed emergency stomas were considered to be located inappropriately and required revision. We were able to avoid increased complication rates in @entity0 with a malpositioned stoma, however unnecessary surgery for an inappropriately placed stoma should be avoided to decrease @entity0 inconvenience and risks. An algorithm is proposed for the placement of a suitable stoma.

title: Stoma placement in obstructive XXXX prior to neo-adjuvant treatment and definitive surgery: A practical guideline.

answer: @entity1


abstract: OBJECTIVE: Despite the low local @entity1 of the used agents, @entity3 -based chemotherapy (CBP) for @entity0 with @entity5 ( @entity5 ) is mostly delivered via a @entity4 ( @entity4 ). Since 2008, CBP is given peripherally in our hospital. METHODS: Medical reports of @entity5 @entity0 who received CBP between September 1991 and August 2014 were evaluated. Complications regarding the way of administration ( @entity4 vs. peripheral venous catheter [PVC]) were classified according to the Common Terminology Criteria of Adverse Events. The complication rates were compared using chi square test and propensity score matching. RESULTS: During 288 cycles in 109 @entity0 , 85 complications (29.5%) were observed with similar rates for overall (PVC 31.3%, @entity4 29.9%; p = 0.820) and grade I complications (21.3%, 25.4%; p = 0.470). More grade II complications were observed in the PVC group (10.0 vs. 1.5%; p < 0.001). @entity2 requiring invasive treatment were found only in the @entity4 group (3.0%; p = 0.120). Using propensity score matching, no differences in overall (p = 0.950), grade I (p = 0.540) and grades II/III (p = 0.590) complications were seen. CONCLUSION: The peripheral and central administration of CBP has similar overall complication rates. Despite more grade II complications, the peripheral administration of CBP is a safe alternative for @entity5 @entity0 . Additionally, no severe @entity2 occurred.

title: XXXX -Based Chemotherapy for Testicular Germ Cell Tumors: Complication Rates of Peripheral versus Central Venous Administration.

answer: @entity3


abstract: This report concerns 34 @entity0 of @entity1 admitted to Taichung Veterans General Hospital, from 1983 to 1994. Among them 26 were male and 8 were female. The age at onset were mostly from 50 to 60. The average duration between onset of symptoms and the date of definite diagnosis was 10 months. The most common presenting symptom was bloody @entity2 (64.7%). Most of our @entity0 were in the moderately severe group of disease (67.6%), according to the severity defined by Truelove and Witts. The most frequent endoscopic findings of mucosa was classified as Grade III (38.2). Descending colon (91.2), rectum (85.3%), and sigmoid colon (88.2%) were the most frequently involved areas. The major clinical course were chronic intermittent and chronic continuous type (55.9%). Extraintestinal manifestations were found in 2 cases: one was found in the skin, and the other in the joint, respectively. Treatment of @entity1 in our series was mainly medical (91.2%). However, 3 @entity0 received emergent surgical intervention, and 10 @entity0 finally underwent operation because of major complications or failure to respond to medical treatment.

title: [ XXXX in Taichung Veterans General Hospital: a clinical study].

answer: @entity1


abstract: BACKGROUND: Risk stratification of @entity5 in @entity4 ( @entity4 ) is mainly based on evaluations from @entity0 at highly specialized centers. AIM: To evaluate risk markers for appropriate @entity1 ( @entity1 ) therapy in an unselected, nationwide cohort of @entity4 . METHODS: @entity0 with an @entity1 due to @entity4 were identified from the Swedish @entity1 Registry since its start in 1995, merged with @entity0 Register data, and medical records were retrieved. Risk markers for @entity2 leading to appropriate @entity1 therapy were analyzed using Cox proportional hazard ratio (HR). RESULTS: Of 321 @entity0 (70.1% males), at least one appropriate therapy occurred in 77 (24.0%) during a mean follow-up of 5.4 years (5.3% per year; primary prevention 4.5%, secondary prevention 7.0%). Cumulative incidences at 1, 3, and 5 years were 8.1%, 15.3%, and 21.3% respectively. Cardioversion effectively restored rhythm in 52% of the first episode and antitachycardia pacing was sufficient in the remaining. For the whole cohort, ejection fraction (EF)<50% (HR 2.63; p<0.001), was associated with appropriate @entity1 therapy. In primary prevention, @entity0 with established risk markers experienced appropriate therapy; @entity3 (HR 2.54; p = 0.010), EF<50% (HR 2.78; p = 0.004), and nonsustained @entity6 (HR 1.80; p = 0.109), had the highest HR, and wall thickness >= 30mm, syncope, exercise blood pressure response, or family history of @entity5 had weaker associations. CONCLUSION: @entity1 therapy successfully terminates @entity2 in @entity4 . In addition to conventional risk markers, a history of @entity3 or EF<50% may be considered in risk stratification. This article is protected by copyright. All rights reserved.

title: Risk Markers and Appropriate Implantable Defibrillator Therapy in XXXX .

answer: @entity4


abstract: OBJECTIVES: To determine the role of preoperative pulmonary function tests (PFTs) in @entity0 with @entity4 ( @entity4 ) evaluated for @entity5 ( @entity5 ), and to evaluate the association between @entity3 and mortality in specific subgroups. METHODS: Between 2008 and 2013, 535 @entity0 with preoperative PFTs underwent @entity5 (transcatheter @entity5 [TAVR], n  =  246; surgical @entity5 [SAVR], n  =  289). The severity of @entity3 determined by the Society of Thoracic Surgeons (STS) definition was evaluated in those with and without a clinical suspicion for @entity3 (smoking, inhaled @entity2 /bronchodilators, or home @entity1 ). The association between @entity3 and 1-year mortality was evaluated. RESULTS: Of the 186 @entity0 (35%) without suspected @entity3 , 39 (21%) had  moderate/severe @entity3 by PFT analysis. Among all @entity0 , 1-year mortality was 12% in those with no @entity3 , 17% in those with no mild @entity3 , 22% in those with moderate @entity3 , and 31% in those with severe @entity3 (P  <  .001, log-rank test). After adjustment, moderate/severe @entity3 was associated with increased 1-year mortality (adjusted hazard ratio, 2.07; 95% confidence interval, 1.30-3.29; P  =  .002); this association was not altered by smoking history, suspicion of @entity3 , New York Heart Association class, or @entity5 type (interaction P value nonsignificant for all). CONCLUSIONS: In @entity0 with @entity4 evaluated for @entity5 , the STS risk score is significantly influenced by the severity of @entity3 , which is determined predominantly by PFT results. Even when @entity3 is not suspected, PFTs are abnormal in many @entity0 undergoing @entity5 . Moderate/severe @entity3 , diagnosed predominantly by PFTs, is an independent predictor of mortality after SAVR or TAVR. Collectively, these findings suggest that PFTs should be a routine part of the risk stratification of @entity0 considered for @entity5 .

title: Preoperative pulmonary function tests predict mortality after surgical or transcatheter XXXX .

answer: @entity5


abstract: AIM: To assess the outcome of @entity0 undergoing bilateral adrenalectomy for @entity5 ( @entity5 ). METHODS: All @entity0 who underwent bilateral adrenalectomy for @entity5 at the Department of Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences hospital between 1991 and 2013 were included. Medical records were reviewed to obtain @entity0 characteristics and follow-up data. RESULTS: Twenty-seven @entity0 were studied. Mean age was 28.74    12.95 years (range 9-60), male:female ratio was 1.7:1. About half that is, 48.19% were of @entity5 (failed @entity10 [ @entity10 ]), 37.04% were of ectopic @entity5 (ECS), and 14.81% were of @entity5 due to bilateral adrenal pathology. Median follow-up period was 80.5 months. Before surgery, 74.1% @entity0 had body mass index > which after surgery declined to <25 in 75% of them. @entity2 was present in 85.2% and after surgery resolved in 40%. @entity1 was present in 44.4% and after surgery resolved in 33% of them. @entity9 and proximal @entity3 were present in 55.6% and 70.4% @entity0 , respectively, and after surgery improved markedly in all @entity0 . @entity7 developed in 36.3% and @entity8 in 41.7% @entity0 during follow-up. Three @entity0 died in perioperative period while three succumbed to the disease during follow-up. Two @entity0 developed recurrence of endogenous @entity6 production during the follow-up period. CONCLUSIONS: Bilateral adrenalectomy is a valid treatment option for palliating severe symptoms in Pituitary Cushing's with failed @entity10 and unlocalized ECS but the procedure is curative for @entity5 due to bilateral @entity4 . Overall morbidity and mortality is higher than other endocrine operations. Co-morbidities tend to be more severe and are a risk factor for mortality during the time @entity0 survives.

title: Bilateral adrenalectomy for XXXX : Pros and cons.

answer: @entity5


abstract: BACKGROUND: Newborn @entity0 undergoing intensive care are at risk of bleeding and @entity1 . Fresh frozen plasma (FFP) is used in hope of preventing these complications, despite poorly defined effects on the coagulation system and lack of proven clinical efficacy. OBJECTIVES AND METHODS: We prospectively evaluated @entity2 and the effect of standardized amount of FFP transfusion (10 mL kg-1 + 4 mL in 2 h) on various coagulation markers in 33 newborn @entity0 during the first 24 h of intensive care. RESULTS: Increased levels of prothrombin fragment @entity3 , @entity4 ( @entity4 ), and d-dimer were found prior to the transfusion in 97%, 81%, and 100% of the @entity0 , respectively. FFP transfusion was associated with a decrease in @entity3 level in 26/32 (81%) of the @entity0 . The extent of @entity3 decrease correlated with the pretransfusion @entity3 level (R = 0.65, P < 0.0001). The @entity0 series was divided into two groups according to increasing pretransfusional @entity3 level: Group 1 (preFFP @entity3 > or = 2.35 nm, n = 16), Group 2 ( @entity3 <2.35 nm, n = 16). In Group 1, @entity3 decreased on average 1.58 nm (P < 0.01) from the baseline during FFP transfusion but no significant change in the level of @entity3 during the transfusion was observed in Group 2. Pretransfusional levels of individual factors or prothrombin time (PT) did not correlate with the FFP-associated decrease in @entity3 level. CONCLUSIONS: In the @entity0 with the highest pretransfusional thrombin formation, FFP had an acute thrombin-reducing effect. Pretransfusion thrombin generation markers, rather than PT or individual pro- and anticoagulants, may be helpful in identifying the @entity0 who will have measurable coagulational effects induced by FFP.

title: Fresh frozen plasma reduces thrombin formation in newborn XXXX .

answer: @entity0


abstract: There is a growing concern about elderly @entity5 . The aim of this study was to evaluate the treatment and clinical outcomes following minimal invasive percutaneous plate osteosynthesis (MIPPO) with the proximal humeral internal locking system (PHILOS) for the treatment of elderly valgus impacted @entity5 . Between May 2008 and May 2012, 27 @entity0 (average age 67.3, range 61-74) with @entity5 were enrolled in the study. The @entity0 were treated with MIPPO using PHILOS-plate through the anterolateral delta-splitting approach. Rehabilitation exercises were done gradually. The NEER score and Constant-Murley score were used to evaluate shoulder function. All the @entity0 were followed up by routine radiological imaging and clinical examination. There were 15 cases of II-part greater tuberosity @entity2 , 10 cases of III-part greater tuberosity @entity2 , and 2 cases of IV-part @entity2 according to the NEER classification. The surgery was successful in all @entity0 with an average follow-up of 20.8 (range: 11-34) months. The @entity2 united in an average of 7.2 (6-14) weeks without implant loosening. According to NEER score, there were 17 excellent, 7 satisfactory, 2 unsatisfactory, and 1 poor. The mean Constant-Murley score was 89.4    4.35. No complication including @entity1 , @entity4 , @entity6 , or @entity3 was observed. In conclusion, the MIPPO technique with the PHILOS through the anterolateral delta-splitting approach seems to be a safe and easy treatment for elderly @entity5 . A case-control study and longer follow-up time are needed.

title: Minimal Invasive Percutaneous Osteosynthesis for Elderly XXXX with the PHILOS.

answer: @entity5


abstract: Computer simulations have been used frequently in the life sciences to investigate the mechanisms of morphologic pattern formation. The cellular automaton program SMN5 is designed to simulate @entity0 growth and to estimate biologic properties by comparing real @entity0 patterns with computer-simulated reference patterns. This method was applied to 195 cases of primary @entity1 . S-100-stained sections were evaluated by image analysis and compared statistically to a reference set of 4000 simulated patterns. Estimates of @entity0 cell proliferation, motility, cell loss, cohesion, stroma destruction, and intercellular signals (autocrine and paracrine factors affecting growth, motility, and cell loss) were calculated. Twelve of 18 estimated parameters correlated significantly with @entity0 progression, as indicated by vertical @entity0 thickness (linear regression analysis: p < or = 0.05), and 13 of 18 parameters carried prognostic significance (log rank test: p < or = 0.05). Poor prognosis was associated particularly with a pronounced increase in the estimates of proliferation, @entity0 cell motility, and stromal degradation. Poor prognosis was also associated with a decrease in the estimates of cell loss, @entity0 cell cohesion, and paracrine growth factor dependence. In multivariate analysis using Cox's proportional hazard model, stromal degradation and motility showed prognostic information in addition to conventional prognostic parameters. The study shows that analytical @entity0 with computer-simulated patterns of a cellular automaton facilitates a functional interpretation of @entity0 morphology, which carries prognostic significance in @entity1 .

title: Computer simulations of histologic patterns in XXXX using a cellular automaton provide correlations with prognosis.

answer: @entity1


abstract: Many @entity2 and immortal cells exhibit telomerase activity that stabilizes telomere lengths, possibly contributing to cell immortality and @entity3 . The aim of this study was to elucidate the clinicopathological relationship between telomerase activity and telomerase reverse transcriptase subunit ( @entity6 ) status in @entity5 . @entity6 status in @entity5 using telomeric repeat amplification protocol (TRAP) and RT-PCR assay, respectively. Telomerase activity and @entity6 were detected in 85.7 and 80.3% of cancerous tissues, respectively. Telomerase activity does not correlate with clinicopathological variables. However, there was an association between @entity4 -correlated expression and @entity6 negative status. @entity1 @entity0 without telomerase activity survived for a significantly longer period than those with telomerase activity. In addition, @entity6 was not associated with the prognosis. @entity6 expression did not correlate well with any clinical parameter. Reactivated telomerase activity may be a poor prognostic factor in NSCLCs.

title: Loss of telomerase activity may be a potential favorable prognostic marker in XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the clinical outcome of the femtosecond laser-assisted @entity0 surgery (FLACS) in our first 300 cases. METHODS: In this retrospective study, the study group comprised 300 cases (300 eyes) in which FLACS was done. The control group comprised 300 cases (300 eyes) in which phacoemulsification was performed. The steps of the FLACS included capsulotomy, @entity4 , @entity5 , and creation of incisions within the peripheral cornea to aid the correction of pre-existing @entity3 . After the FLACS, 2.2-mm coaxial micro-incision phacoemulsification and implantation of an intraocular lens were operated. The preoperative best corrected visual acuity (BCVA) and postoperative uncorrected visual acuity (UCVA), the cumulative dissipated energy (CDE) of the phacoemulsification, and the parameters of the FLACS, including the docking time, the suction time and the laser time, were recorded. The complications of the FLACS were analyzed. RESULTS: The FLACS was successfully completed in 99.33% of the cases. The docking time was (24.6    16.8) sec, the suction time was (101.27    20.09) sec, and the laser time was (23.3    5.5) sec. The most common complications of the FLACS included suction break (7/300, 2.33%), @entity2 (58/300, 19.33%), pupillary constriction (47/300, 15.67%), incision at a wrong site (13/300, 4.33%), anterior capsular tag (17/300, 5.67%), decentration of the capsulorhexis (11/300, 3.67%), failure to split the lens nucleus (5/300, 1.67%), and posterior capsular @entity1 (1/300, 0.33%). The CDE was 5.52    5.18 in the FLACS group and 8.37    7.91 in the traditional phaco group (P < 0.05). The UCVA was 0.12    0.08 and 0.13    0.11 at 1 month after the FLACS and traditional phaco, respectively (P > 0.05). CONCLUSIONS: Compared with the conventional phacoemulsification surgery, the FLACS can achieve less CDE and better early postoperative visual acuity. Long-term effects remain to be investigated.

title: [Preliminary evaluation of the femtosecond laser-assisted XXXX surgery in 300 cases].

answer: @entity0


abstract: PURPOSE: @entity1 boards (MDTs) are conducted worldwide for the management of @entity0 with @entity1 , and they deliver a higher standard of care by simultaneously involving different specialists in diagnosis and treatment planning. However, information of paediatric MDTs functioning is scarce. A pilot study was conducted in Spain in the frame of the European Expert Paediatric Oncology Reference Network for Diagnostics and Treatment (ExPO-r-Net). METHODS: A specific questionnaire was designed regarding various features of MDT practice. Data collected included information on the centres and the team, infrastructure for meetings, MDT organization/logistics and clinical decision-making. The survey was distributed to all Paediatric Oncology Units that register @entity0 in the Spanish Registry of Childhood Tumours (RETI-SEHOP). RESULTS: 32 out of 43 contacted centres responded the questionnaire (74  % response rate; 88  % response rate for centres with >25 new @entity0 /year). All units with >25 new @entity0 /year have a dedicated Paediatric MDT compared to 76  % of units with  <=25 new @entity0 /year. MDTs should be improved at institutional level by clear protected time in service planning for all specialists involved, incentives for attendance and attendance registration. Clinical decision-making process and follow-up of recommendation adherence should be assessed and potential legal responsibilities for physicians participating in @entity1 Board defined. Network collaboration through virtual MDTs, using available videoconferencing tools, is an opportunity to share expertise among centres.

title: XXXX boards in Spain: a national survey.

answer: @entity1


abstract: 43 kidney recipients were followed up for 12 months after renal transplantation. In 13 @entity0 treated with @entity1 for 6 months polyglobulia was found, which subsided after conversion of immunosuppressive therapy. A highly significant correlation was found between the presence of the antigen A3 and the polyglobulia in kidney recipients treated by @entity1 . The serum ferritin level was not elevated in kidney recipients who were carriers of the " @entity3 alleles". Results obtained in this study seem to justify the following conclusions: 1. Kidney recipients who are carriers of " @entity3 alleles" show a threefold higher risk of posttransplant polyglobulia. 2. Presence of " @entity3 alleles" is not an absolute predictor of polyglobulia in @entity0 after kidney transplantation. 3. Both etiology and pathogenesis of posttransplant polyglobulia do not seem to be homogeneous. @entity1 , in contrast to @entity2 , seems to have a promoting effect on the development of posttransplant polyglobulia. Therefore treatment of kidney transplant @entity0 with @entity1 , who are carriers of " @entity3 alleles", needs careful monitoring.

title: [The role of " XXXX alleles" in the pathogenesis of polyglobulia after renal transplantation].

answer: @entity3


abstract: OBJECTIVE: To investigate the injury effect of high frequency electrocoagulation ( @entity2 ) by ultrafine-needle on the cutaneous @entity1 by histopathologic study of cock comb. METHODS: 32 male cocks were randomly divided into 4 groups with 8 animals in each group. 3 experimental groups received @entity2 with different power (6W, 8W, 10W) on the cock comb. Specimens were taken from cock combs for histologic study immediately after treatment and 7, 14, 21, 28 days later. RESULTS: After treatment, the cock combs turned pale and followed with @entity0 formation. The shape of combs changed a lot after high power treatment. Immediately after treatment, the capillary number in the experimental groups decreased markedly under light microscope, compared with that in control group (P < 0.05). After that, the capillary number in experimental group increased. 7 days after treatment, the capillary number in experimental groups was still significantly lower than that in control groups (P < 0.01), but not markedly different between the three experiment groups (P > 0.05). Collagen formation also increased after treatment (P < 0.05), which was higher in experimental groups with high power (P < 0.05, correlation coefficient r > 0.5). CONCLUSIONS: @entity2 with ultrafine needle can effectively decrease the capillary number in cock comb. The 6W treatment is mini-invasive and will not destroy the comb shape with good cosmetic results. The technique may be used for the treatment of cutaneous @entity1 .

title: [Effect of high frequency electrocoagulation by ultrafine-needle on the cutaneous XXXX : a preliminary study on cock combs].

answer: @entity1


abstract: UNASSIGNED: @entity5 is a disease with a high morbidity and mortality. It may be caused by the zoonotic pathogen @entity6 , which is part of the commensal oral flora in @entity1 and @entity3 . We report three cases of @entity6 @entity4 in a nationwide cohort study of @entity5 @entity0 and performed a review of the literature. Three episodes of @entity6 @entity4 were identified in three @entity0 included in a nationwide cohort study from 2006 through 2014. The calculated annual incidence was 0.03 per million adults. When combined with the literature, 33 @entity0 were identified of which 28 were male (85%). The median age was 63  years, and 13 (42%) were immunocompromised, which consisted of alcoholism in 7 (21%). Animal contact could be established in 29 of 30 @entity0 (93%) and consisted of @entity1 bites in 22 of 29 (76%). One @entity0 died (3%) and 8 had neurological sequelae upon discharge (25%), most often @entity2 (n  =  6, 19%). @entity6 @entity4 is associated with @entity1 bites. Although mortality is relatively low, survivors often have neurological sequelae.

title: XXXX @entity4 : Three Cases and a Review of the Literature.

answer: @entity6


abstract: UNASSIGNED: @entity5 is a disease with a high morbidity and mortality. It may be caused by the zoonotic pathogen @entity6 , which is part of the commensal oral flora in @entity1 and @entity3 . We report three cases of @entity6 @entity4 in a nationwide cohort study of @entity5 @entity0 and performed a review of the literature. Three episodes of @entity6 @entity4 were identified in three @entity0 included in a nationwide cohort study from 2006 through 2014. The calculated annual incidence was 0.03 per million adults. When combined with the literature, 33 @entity0 were identified of which 28 were male (85%). The median age was 63  years, and 13 (42%) were immunocompromised, which consisted of alcoholism in 7 (21%). Animal contact could be established in 29 of 30 @entity0 (93%) and consisted of @entity1 bites in 22 of 29 (76%). One @entity0 died (3%) and 8 had neurological sequelae upon discharge (25%), most often @entity2 (n  =  6, 19%). @entity6 @entity4 is associated with @entity1 bites. Although mortality is relatively low, survivors often have neurological sequelae.

title: @entity6 XXXX : Three Cases and a Review of the Literature.

answer: @entity4


abstract: PURPOSE OF REVIEW: @entity3 ( @entity3 ) is a common heterogenous @entity2 affecting @entity0 and adults. The exact mechanism is not completely understood. In this review, we aim to summarize our recent findings regarding etiologies and pathogenesis of @entity3 in @entity0 and review recent studies investigating inflammatory patterns in the upper airways in @entity0 and adults with @entity3 . RECENT FINDINGS: There are only a few small studies measuring upper airway @entity1 in @entity0 with @entity3 . These studies demonstrated more toward eosinophilic and T-cell driven inflammatory pattern. Cytokine patterns in upper airways seem to correlate with @entity5 symptoms in @entity0 with @entity3 . Adult studies demonstrate eosinophilic and Th-2 (T helper-1) driven @entity1 in @entity3 with @entity4 and @entity6 (T helper-2) driven @entity1 in @entity3 without @entity4 . SUMMARY: Current knowledge about the characteristics of tissue @entity1 in upper airways in @entity0 with @entity3 is limited. More studies are needed to better understand the pathogenesis and better define the subgroups of @entity3 . The findings of such studies will lead to identifying the biological targets to treat this condition.

title: Direct measurement of upper airway @entity1 in @entity0 with chronic rhinosinusitis: implications for XXXX .

answer: @entity5


abstract: PURPOSE OF REVIEW: @entity3 ( @entity3 ) is a common heterogenous @entity2 affecting @entity0 and adults. The exact mechanism is not completely understood. In this review, we aim to summarize our recent findings regarding etiologies and pathogenesis of @entity3 in @entity0 and review recent studies investigating inflammatory patterns in the upper airways in @entity0 and adults with @entity3 . RECENT FINDINGS: There are only a few small studies measuring upper airway @entity1 in @entity0 with @entity3 . These studies demonstrated more toward eosinophilic and T-cell driven inflammatory pattern. Cytokine patterns in upper airways seem to correlate with @entity5 symptoms in @entity0 with @entity3 . Adult studies demonstrate eosinophilic and Th-2 (T helper-1) driven @entity1 in @entity3 with @entity4 and @entity6 (T helper-2) driven @entity1 in @entity3 without @entity4 . SUMMARY: Current knowledge about the characteristics of tissue @entity1 in upper airways in @entity0 with @entity3 is limited. More studies are needed to better understand the pathogenesis and better define the subgroups of @entity3 . The findings of such studies will lead to identifying the biological targets to treat this condition.

title: Direct measurement of upper airway XXXX in @entity0 with chronic rhinosinusitis: implications for @entity5 .

answer: @entity1


abstract: PURPOSE OF REVIEW: @entity3 ( @entity3 ) is a common heterogenous @entity2 affecting @entity0 and adults. The exact mechanism is not completely understood. In this review, we aim to summarize our recent findings regarding etiologies and pathogenesis of @entity3 in @entity0 and review recent studies investigating inflammatory patterns in the upper airways in @entity0 and adults with @entity3 . RECENT FINDINGS: There are only a few small studies measuring upper airway @entity1 in @entity0 with @entity3 . These studies demonstrated more toward eosinophilic and T-cell driven inflammatory pattern. Cytokine patterns in upper airways seem to correlate with @entity5 symptoms in @entity0 with @entity3 . Adult studies demonstrate eosinophilic and Th-2 (T helper-1) driven @entity1 in @entity3 with @entity4 and @entity6 (T helper-2) driven @entity1 in @entity3 without @entity4 . SUMMARY: Current knowledge about the characteristics of tissue @entity1 in upper airways in @entity0 with @entity3 is limited. More studies are needed to better understand the pathogenesis and better define the subgroups of @entity3 . The findings of such studies will lead to identifying the biological targets to treat this condition.

title: Direct measurement of upper airway @entity1 in XXXX with chronic rhinosinusitis: implications for @entity5 .

answer: @entity0


abstract: BACKGROUND: The understanding of prognostic factors has facilitated stratification of risk groups in differentiated @entity4 . The prognostic factors have clearly identified the risk groups as low, intermediate, and high risk. Risk group categorization has facilitated a selective surgical approach for @entity4 . METHODS: A retrospective review of 228 @entity0 with follicular @entity4 was undertaken. Various prognostic factors and risk groups were analyzed. Univariate and multivariate analyses were performed, and the survival curves were plotted by the Kaplan-Meier method. Fifty-nine (26%) @entity0 presented with H  rthle cell histology. The risk groups revealed 62 @entity0 in the low, 84 in the intermediate, and 82 in the high risk groups. RESULTS: The 10-year survival for low, intermediate, and high risk groups was 98%, 88%, and 56%, respectively, and the 20-year survival for the same groups was 97%, 87%, and 49%, respectively. Adverse prognostic factors included age older than 45 years (p < 0.001), H  rthle cell variety (p = 0.05), extrathyroidal extension, @entity2 size exceeding 4 cm, and the presence or absence of distant @entity1 (p < 0.001). Gender, focality, and presence of lymph node @entity1 had no significant impact on prognosis. CONCLUSIONS: @entity0 in the low risk group have excellent survival, whereas the high risk group behaves poorly. Appropriate selection of treatment for the @entity3 and adjuvant therapy should be considered on the basis of the prognostic factors and risk group analysis.

title: Prognostic factors and risk group analysis in follicular XXXX .

answer: @entity4


abstract: UNASSIGNED: The purpose of this study was to examine whether or not lower limb sprint interval training following arm resistance training influences training response of arm muscle strength and @entity2 . Twenty @entity0 participated in this study. We divided subjects into @entity3 ( @entity3 , n=6) and concurrent training group (CT, n=6). The @entity3 program was designed to induce muscular @entity2 (3 sets x 10 repetitions (reps) at 80% 1 repetition maximum [1RM] of arm curl exercise), and was performed in an 8-week training schedule carried out 3 times per week on nonconsecutive days. Subjects assigned to the CT group performed identical protocols as strength training (ST) and modified sprint interval training (4 sets of 30-s maximal effort, separated in 4m 30-s rest intervals) on the same day. Pre- and post-test maximal @entity1 consumption (VO2max), muscle cross-sectional area ( @entity4 ), and 1RM were measured. Significant increase in VO2max from pre- to post-test was observed in the CT group (p=0.010, ES=1.84), but not in the @entity3 group (p= 0.559, ES= 0.35). Significant increase in @entity4 from pre- to post-test was observed in the @entity3 group (p=0.030, ES=1.49), but not in the CT group (p= 0.110, ES= 1.01). Significant increase in 1RM from pre- to post-test was observed in the @entity3 group (p= 0.021, ES= 1.57), but not in the CT group (p= 0.065, ES= 1.19). In conclusion, our data indicate that concurrent lower limb sprint interval training interfere with arm muscle @entity2 and strength.

title: The effect of high-intensity interval cycling sprints subsequent to arm-curl exercise on upper-body muscle strength and XXXX : A pilot study.

answer: @entity2


abstract: 1. In @entity6 / @entity5 anaesthetized male @entity1 , the hypothalamus and pituitary stalk were exposed by a transpharyngeal approach. Cells recorded with glass micro-electrodes from the ventral hypothalamus near the bifurcation of the internal carotid artery were identified as supraoptic neurones only when their antidromic action potential evoked at constant latency by stimulation of the pituitary stalk was cancelled by collision with a spontaneously occurring action potential.2. More than 80% of the identified cells were spontaneously active. The frequency of firing was often slow (under 1 Hz) and rather irregular. More than half the cells, however, had a more distinctive firing pattern which recurred every 1-3 min and consisted of a period of low or absent activity alternating with periods of quite marked discharge which occasionally exceeded 20 Hz. This periodicity was retained when the over-all activity was enhanced by an intracarotid injection of 0.2 @entity0 % (w/v) @entity3 .3. Of fifty-two cells tested, thirty-six were excited by @entity2 applied by iontophoresis from a multibarrelled micropipette with average ejection currents of 35 +/- 5 nA (S.D. of thirty-six observations). Ten of these cells were also excited by @entity4 applied with similar currents.

title: The activity of identified supraoptic neurones and their response to XXXX applied by iontophoresis.

answer: @entity2


abstract: @entity4 is uncommon. One of the main problems in the treatment of @entity4 has been the lack of accuracy of diagnostic tests. Now, with the use of computed tomographic scanning with and without @entity6 in the subarachnoid space, this accuracy has greatly improved. Computed tomography scanning can demonstrate the type and level of the lesion even when the myelographic study is negative. We have reviewed 280 cases; a peak incidence was noted in the fourth decade with 75% of the protruded discs occurring below T-8. Back @entity3 was the most common presenting symptom followed by @entity2 . By the time of diagnosis, 70% of the @entity0 had signs of @entity5 . A small group of @entity0 could be identified that invariably had a good prognosis. They had a history of @entity1 , symptoms lasting less than a month, and soft disc herniation. Regarding the results of surgical treatment, there was a success rate ranging from 57% for decompressive laminectomy to over 80% for the posterolateral, lateral, and transthoracic approaches.

title: XXXX . Improved diagnosis with computed tomographic scanning and a review of the literature.

answer: @entity4


abstract: The effects of acute pressure overload of the right and left ventricle on the left ventricular hemodynamics, coronary circulation, and myocardial metabolism in @entity0 were investigated by banding of the main pulmonary artery and by producing two models of aortic constriction with (type B) and without (type A) aortocoronary bypass. Pulmonary artery banding (left ventricular preload reduction) showed right ventriculr systolic pressure (RVSP), right ventricular end-diastolic pressure (RVEDP), and right ventricular dP/dtmax significantly elevated, but left ventricular systolic pressure (LVSP), left ventricular (dP/dtmax)/IIP slightly decreased, contrary to a slight increase of left ventricular end-diastolic pressure (LVEDP). The blood flow of the left coronary circumflex artery (CBF) was slightly decreased, but the aortic blood flow (AoF) and left ventricular work per minute (LVW) were significantly reduced. As to myocardial metabolism, the coronary arteriovenous difference (delta) of @entity5 , mainly @entity1 (G) and @entity3 (L), increased, while that of non-esterified @entity2 (NEFA) showed a significant reduction. @entity4 (left ventricular afterload increase) showed, both in types A and B, left ventricular systolic pressure, left ventricular end-diastolic pressure, and left ventricular work per minute were increased. However, aortic systolic and diastolic pressure were significantly decreased. The blood flow of the left coronary circumflex artery tended to increase in both types. The myocardial @entity5 uptake tended to increase after aortic constriction in both types. However, the uptake of non-esterified @entity2 was increased after aortic constriction in type A, but decreased in type B. This difference in uptake of non-esterified @entity2 might be induced by the difference of the functional state of the left ventricle.

title: Effects of right and left ventricular pressure overload on left ventricular function and metabolism in XXXX .

answer: @entity0


abstract: BACKGROUND: Precocious cervical ripening, as defined by cervical @entity4 on transvaginal sonography, has prompted a broad evaluation of secondary strategies (such as cerclage, vaginal @entity2 , or a cervical pessary) to prevent @entity3 . However, there is still a lack  of direct comparisons between individual treatments or their combinations. OBJECTIVE: We sought to compare at-risk @entity0 and screening @entity0 who had been treated with cervical pessary alone with @entity0 who had been treated with pessary plus vaginal @entity2 . STUDY DESIGN: This is a pre- and postintervention cohort study from a @entity3 clinic where placement of a cervical pessary has been the standard treatment since 2008 for at-risk @entity0 defined by (1) a history of spontaneous @entity1 at <37 weeks of gestation, (2) conization, or (3) a cerclage because of a previous short cervical length of <3rd percentile and, additionally, with a cervical length of <10th percentile in the ongoing pregnancy. @entity0 who did not meet the criteria for the "at risk" group, but who had a cervical length of <3rd percentile comprised the screening group. From July 2011 onward, vaginal @entity2 (200 mg, suppositories) was prescribed in addition to the pessary. Both at-risk @entity0 (n  = 55) and screening @entity0 (n  = 51) were treated at the time of diagnosis. The primary outcome was the rate of preterm deliveries at <34 weeks of gestation. Secondary outcomes included deliveries at <28, <32, and <37 weeks of gestation, the days from start of therapy until delivery, a composite index of neonatal outcome, and the number of days in the neonatal intensive care unit. Primary and secondary outcomes were compared between groups with the use of multivariable models to adjust for possible confounders. RESULTS: Delivery at <34 weeks of gestation occurred in 17 of 53 @entity0 (32.1%) who were treated with pessary plus @entity2 , compared with 13 of 53 @entity0 (24.5%) who were treated with pessary alone (P  = .57). Similarly, there was no difference in the rate of @entity3 at <28, <32, or <37 weeks of gestation. The composite poor neonatal outcome was 15.1% in the pessary group vs 18.9% in the combined group (P  = .96). The mean duration of stay in the neonatal intensive care unit was 46.5 days (range, 9-130 days) in the combined vs  52.0 days (range, 3-151 days) in the pessary group (P < .001). CONCLUSION: In this cohort study, treatment of precocious cervical ripening with cervical pessary plus vaginal @entity2 did not reduce the rates of @entity3 at <28, <32, <34, or <37 weeks of gestation compared with pessary alone. The neonatal intensive care use was shorter in @entity0 who received additional vaginal @entity2 , although there was no difference in composite poor neonatal outcome. These preliminary results may serve as a pilot for future trials and provide a basis for treatment until larger trials are completed.

title: Vaginal XXXX combined with cervical pessary: A chance for pregnancies at risk for @entity1 ?

answer: @entity2


abstract: BACKGROUND: Precocious cervical ripening, as defined by cervical @entity4 on transvaginal sonography, has prompted a broad evaluation of secondary strategies (such as cerclage, vaginal @entity2 , or a cervical pessary) to prevent @entity3 . However, there is still a lack  of direct comparisons between individual treatments or their combinations. OBJECTIVE: We sought to compare at-risk @entity0 and screening @entity0 who had been treated with cervical pessary alone with @entity0 who had been treated with pessary plus vaginal @entity2 . STUDY DESIGN: This is a pre- and postintervention cohort study from a @entity3 clinic where placement of a cervical pessary has been the standard treatment since 2008 for at-risk @entity0 defined by (1) a history of spontaneous @entity1 at <37 weeks of gestation, (2) conization, or (3) a cerclage because of a previous short cervical length of <3rd percentile and, additionally, with a cervical length of <10th percentile in the ongoing pregnancy. @entity0 who did not meet the criteria for the "at risk" group, but who had a cervical length of <3rd percentile comprised the screening group. From July 2011 onward, vaginal @entity2 (200 mg, suppositories) was prescribed in addition to the pessary. Both at-risk @entity0 (n  = 55) and screening @entity0 (n  = 51) were treated at the time of diagnosis. The primary outcome was the rate of preterm deliveries at <34 weeks of gestation. Secondary outcomes included deliveries at <28, <32, and <37 weeks of gestation, the days from start of therapy until delivery, a composite index of neonatal outcome, and the number of days in the neonatal intensive care unit. Primary and secondary outcomes were compared between groups with the use of multivariable models to adjust for possible confounders. RESULTS: Delivery at <34 weeks of gestation occurred in 17 of 53 @entity0 (32.1%) who were treated with pessary plus @entity2 , compared with 13 of 53 @entity0 (24.5%) who were treated with pessary alone (P  = .57). Similarly, there was no difference in the rate of @entity3 at <28, <32, or <37 weeks of gestation. The composite poor neonatal outcome was 15.1% in the pessary group vs 18.9% in the combined group (P  = .96). The mean duration of stay in the neonatal intensive care unit was 46.5 days (range, 9-130 days) in the combined vs  52.0 days (range, 3-151 days) in the pessary group (P < .001). CONCLUSION: In this cohort study, treatment of precocious cervical ripening with cervical pessary plus vaginal @entity2 did not reduce the rates of @entity3 at <28, <32, <34, or <37 weeks of gestation compared with pessary alone. The neonatal intensive care use was shorter in @entity0 who received additional vaginal @entity2 , although there was no difference in composite poor neonatal outcome. These preliminary results may serve as a pilot for future trials and provide a basis for treatment until larger trials are completed.

title: Vaginal @entity2 combined with cervical pessary: A chance for pregnancies at risk for XXXX ?

answer: @entity1


abstract: UNASSIGNED: As @entity3 reuptake inhibitor (SRI) use may decrease platelet function, previous research has shown a relationship between SRI use and an increased risk for @entity5 and @entity2 . The literature regarding the association between SRI use during pregnancy and increased @entity2 at delivery, referred to as postpartum @entity2 (PPH), is mixed. In secondary analyses from two prospective observational studies of pregnant @entity0 with @entity4 , 263 @entity0 were exposed to an SRI (n  =  51) or not (n  =  212) in the third trimester. To be precise, we used the terminology estimated @entity1 (EBL) >600  cc rather than the term PPH because the current definition of PPH differs. The occurrence of EBL >600  cc was determined using the Peripartum Events Scale (PES) completed from obstetrical records by a blinded medically trained member of the study team. EBL >600  cc occurred in 8.7% of @entity0 in this cohort. There was no statistically significant difference in the rates of EBL >600  cc in the 24  h after delivery in @entity0 taking SRIs during the third trimester (9.8%) compared to non-exposed @entity0 (8.5%). Utilizing generalizing estimating equations, the odds of EBL >600  cc in each group were not significantly different (OR 1.17, CI-0.41-3.32, p  =  0.77). When the SRI group was limited to @entity0 with exposure at the time of delivery, the difference in the odds of EBL >600  cc was unchanged (OR 1.16, CI  =  0.37-3.64, p  =  0.79). In population, both third trimester and use at delivery of SRIs during pregnancy was not associated with an increased risk of excessive @entity1 .

title: Is third trimester @entity3 reuptake inhibitor use associated with postpartum XXXX ?

answer: @entity2


abstract: UNASSIGNED: As @entity3 reuptake inhibitor (SRI) use may decrease platelet function, previous research has shown a relationship between SRI use and an increased risk for @entity5 and @entity2 . The literature regarding the association between SRI use during pregnancy and increased @entity2 at delivery, referred to as postpartum @entity2 (PPH), is mixed. In secondary analyses from two prospective observational studies of pregnant @entity0 with @entity4 , 263 @entity0 were exposed to an SRI (n  =  51) or not (n  =  212) in the third trimester. To be precise, we used the terminology estimated @entity1 (EBL) >600  cc rather than the term PPH because the current definition of PPH differs. The occurrence of EBL >600  cc was determined using the Peripartum Events Scale (PES) completed from obstetrical records by a blinded medically trained member of the study team. EBL >600  cc occurred in 8.7% of @entity0 in this cohort. There was no statistically significant difference in the rates of EBL >600  cc in the 24  h after delivery in @entity0 taking SRIs during the third trimester (9.8%) compared to non-exposed @entity0 (8.5%). Utilizing generalizing estimating equations, the odds of EBL >600  cc in each group were not significantly different (OR 1.17, CI-0.41-3.32, p  =  0.77). When the SRI group was limited to @entity0 with exposure at the time of delivery, the difference in the odds of EBL >600  cc was unchanged (OR 1.16, CI  =  0.37-3.64, p  =  0.79). In population, both third trimester and use at delivery of SRIs during pregnancy was not associated with an increased risk of excessive @entity1 .

title: Is third trimester XXXX reuptake inhibitor use associated with postpartum @entity2 ?

answer: @entity3


abstract: BACKGROUND: Current research has established @entity2 as one of the main modifiable risk factors for @entity4 . However, evidence on the relationships of total and regional body composition measures as well as @entity6 with cognitive functioning in the older population remains inconsistent. METHODS: Data are based on 1,570 @entity0 from the British Regional Heart Study (BRHS), a cohort of older British @entity0 from 24 British towns initiated in 1978-80, who were re-examined in 2010-12, aged 71-92 years. Cognitive functioning was assessed with the Test-Your-Memory cognitive screening tool. Body composition characteristics assessed using bioelectrical impedance analysis included total fat mass (FM), central FM, peripheral FM, and visceral fat level. @entity6 was defined using the European Working Group on @entity6 in Older @entity0 (EWGSOP) definition of severe @entity6 and the Foundation for the National Institutes of Health (FNIH) @entity6 project criteria. RESULTS: Among 1,570 @entity0 , 636 (41  %) were classified in the @entity4 ( @entity4 ) and 133 (8  %) in the @entity4 ( @entity4 ) groups. Age-adjusted multinomial logistic regressions showed that compared with @entity0 in the normal cognitive ageing group, those with @entity4 were more likely to have waist circumference >102  cm, BMI >30  kg/m(2), to be in the upper quintile of total FM, central FM, peripheral FM and visceral fat level and to be sarcopenic. The relationships remained significant for total FM (RR   =   2.16, 95  % CI 1.29-3.63), central FM (RR   =   1.85, 95  % CI 1.09-3.14), peripheral FM (RR   =   2.67, 95  % CI 1.59-4.48), visceral fat level (RR   =   2.28, 95  % CI 1.32-3.94), BMI (RR   =   2.25, 95  % CI 1.36-3.72) and waist circumference (RR   =   1.63, 95  % CI 1.05-2.55) after adjustments for alcohol, smoking, social class, physical activity and history of @entity3 or @entity1 . After further adjustments for @entity5 and insulin resistance, central FM, waist circumference and @entity6 were no longer significantly associated with @entity4 . CONCLUSIONS: Increased levels of peripheral FM, visceral fat level, and BMI are associated with @entity4 among older @entity0 . Distinct pathophysiological mechanisms link regional adipose tissue deposition and cognitive functioning.

title: The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British XXXX .

answer: @entity0


abstract: Intestinal chemosensory signaling pathways involving the gustatory G-protein, gustducin, and bitter taste receptors (TAS2R) have been implicated in gut hormone release. Alterations in gut hormone profiles may contribute to the success of bariatric surgery. This study investigated the involvement of the gustatory signaling pathway in the development of diet-induced @entity1 and the therapeutic potential of targeting TAS2Rs to induce body @entity4 . a-gustducin-deficient (a-gust-/-) @entity0 became less @entity1 than @entity3 ( @entity3 ) @entity0 when fed a high-fat diet (HFD). @entity6 ( @entity6 ) mass was lower in a-gust-/- @entity0 due to @entity2 as a result of increases in brown adipose tissue (BAT) thermogenic activity, involving increased protein expression of uncoupling protein 1. Intra-gastric treatment of @entity1 and a-gust-/- @entity0 with the bitter agonists @entity8 (DB) or @entity7 (Q) during 4 weeks resulted in an a-gustducin-dependent @entity5 associated with a decrease in food intake (DB), but not involving major changes in gut peptide release. Both @entity6 and 3T3-F442A pre-adipocytes express TAS2Rs. Treatment of pre-adipocytes with DB or Q decreased differentiation into mature adipocytes. In conclusion, interfering with the gustatory signaling pathway protects against the development of HFD-induced @entity1 presumably through promoting BAT activity. Intra-gastric bitter treatment inhibits @entity5 , possibly by directly affecting adipocyte metabolism.

title: The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in XXXX .

answer: @entity0


abstract: INTRODUCTION: Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) is an important tool in the management of advanced germ cell @entity1 , @entity3 . AIM: We present the 16-year experience with PC-RPLND in a single Irish tertiary referral centre, and compare our results to the major speciality centres worldwide. METHODOLOGY: All 78 @entity0 undergoing PC-RPLND for the treatment of metastatic @entity1 between January 1996 and December 2011 were included. Medical records were reviewed and up to date follow-up obtained from primary referral centres, @entity0 's GPs and individual @entity0 interview. RESULTS: The mean age at diagnosis was 28.5      7  years. Initial pathology included @entity3 62.8  %, @entity3 6.4  % and combined 19.2  %. All @entity0 underwent pre-operative chemotherapy. The resection template utilised was bilateral infra-hilar in 29.5  %, unilateral  infra-hilar in 46.2  % and supra-hilar in 20.5  %. Complete abdominal remission was achieved in all but one @entity0 . Additional procedures were required in 38.5  % of @entity0 (n  =  30). Clavien Dindo grade three or four complications were seen in 8.9  %, including five @entity0 who required early reoperation. Histology of RPLND specimen showed mature @entity2 (41  %) and active @entity1 (11.5  %). Follow-up data were available for 66 @entity0 (85  %). Median follow-up was 101 (11-207) months. Nine @entity0 relapsed with median time to relapse 15 (8-60) months. Overall 5-year survival rate was 95.2  % (four deaths). CONCLUSION: In this relatively small series due to small population and low disease incidence, we have shown acceptable peri-operative course, morbidity and oncological outcomes with PC-RPLND compared to major international centres.

title: Post-chemotherapy retroperitoneal lymph node dissection in the management of metastatic XXXX : the 16-year experience in an Irish setting.

answer: @entity1


abstract: OBJECTIVES: The 2012 international guidelines state that surgery should be considered for all surgically fit @entity0 with @entity3 ( @entity4 )/mixed @entity5 ( @entity5 ). This study evaluated the follow-up results of @entity4 /mixed @entity5 and risk factors for progression or @entity1 . METHODS: @entity0 with @entity4 /mixed @entity5 were retrospectively enrolled and divided into surgical and nonsurgical groups. These 2 groups were compared and further categorized as progression/ @entity1 or not. In the nonsurgical group, disease progression was defined as radiologic @entity1 growth or adjacent organ invasion. RESULTS: Data from 101 @entity0 (73 males; mean [SD] age, 66.3   [9.1]   years), including 27 and 74 in the nonsurgical and surgical groups, respectively, were analyzed. Mural nodules were more frequently detected in the surgical group (7.4% vs 31.1%, P = 0.018), whereas more multifocal cysts were observed in the nonsurgical group (40.7% vs 20.3%, P = 0.037). Forty-one @entity0 (40.6%) showed progression or @entity1 . Multivariate analysis showed that main pancreatic duct of 10 mm or greater (odds ratio, 4.368; P = 0.024) and pre-existing @entity2 (odds ratio, 3.077; P = 0.046) were independent risk factors for progression or @entity1 . CONCLUSIONS: A watchful waiting strategy could be feasible for some @entity0 with @entity4 /mixed @entity5 , particularly those with a main pancreatic duct of less than 10 mm and without @entity2 .

title: Risk Factors for Progression or Malignancy in Main-Duct and Mixed-Type XXXX .

answer: @entity3


abstract: OBJECTIVE: To explore and compare barriers to early presentation of self-discovered @entity0 in @entity4 . DESIGN: A qualitative interview study with thematic analysis of transcripts. @entity1 : 67 @entity1 with self-discovered breast symptoms were included in the analysis. Of these, 36% were of Malay ethnicity, 39% were Chinese and 25% Indian, with an average age of 58   years (range 24-82   years). The number of @entity1 diagnosed at early stages of @entity2 almost equalled those at advanced stages. Approximately three-quarters presented with a painless lump, one-quarter experienced a @entity3 lump and 10% had atypical symptoms. SETTING: University hospital setting in @entity4 . RESULTS: @entity1 revealed barriers to early presentation not previously reported: the poor quality of online website information about breast symptoms, financial issues and the negative influence of relatives in both countries, while perceived poor quality of care and services in state-run hospitals and misdiagnosis by healthcare professionals were reported in Malaysia. The pattern of presentation by ethnicity remained unchanged where more Malay delayed help-seeking and had more @entity2 compared to Chinese and Indian @entity1 . CONCLUSIONS: There are few differences in the pattern of presentation and in the reported barriers to seek medical care after symptom discovery between @entity4 despite their differing economic status. Strategies to reduce delayed presentation are: a need to improve knowledge of disease, symptoms and causes, quality of care and services, and quality of online information; and addressing fear of diagnosis, treatment and hospitalisation, with more effort focused on the Malay ethnic group. Training is needed to avoid missed diagnoses and other factors contributing to delay among health professionals.

title: Barriers to early presentation of self-discovered XXXX in @entity4 : a qualitative multicentre study.

answer: @entity0


abstract: OBJECTIVE: To explore and compare barriers to early presentation of self-discovered @entity0 in @entity4 . DESIGN: A qualitative interview study with thematic analysis of transcripts. @entity1 : 67 @entity1 with self-discovered breast symptoms were included in the analysis. Of these, 36% were of Malay ethnicity, 39% were Chinese and 25% Indian, with an average age of 58   years (range 24-82   years). The number of @entity1 diagnosed at early stages of @entity2 almost equalled those at advanced stages. Approximately three-quarters presented with a painless lump, one-quarter experienced a @entity3 lump and 10% had atypical symptoms. SETTING: University hospital setting in @entity4 . RESULTS: @entity1 revealed barriers to early presentation not previously reported: the poor quality of online website information about breast symptoms, financial issues and the negative influence of relatives in both countries, while perceived poor quality of care and services in state-run hospitals and misdiagnosis by healthcare professionals were reported in Malaysia. The pattern of presentation by ethnicity remained unchanged where more Malay delayed help-seeking and had more @entity2 compared to Chinese and Indian @entity1 . CONCLUSIONS: There are few differences in the pattern of presentation and in the reported barriers to seek medical care after symptom discovery between @entity4 despite their differing economic status. Strategies to reduce delayed presentation are: a need to improve knowledge of disease, symptoms and causes, quality of care and services, and quality of online information; and addressing fear of diagnosis, treatment and hospitalisation, with more effort focused on the Malay ethnic group. Training is needed to avoid missed diagnoses and other factors contributing to delay among health professionals.

title: Barriers to early presentation of self-discovered @entity0 in XXXX : a qualitative multicentre study.

answer: @entity4


abstract: INTRODUCTION: @entity6 ( @entity6 ) is associated with high mortality rate, up to 25%. There is still conflicting reports regarding the most appropriate management, conservative versus nephrectomy. OBJECTIVE: To describe the outcome of @entity0 with @entity6 . METHODS: We retrospectively reviewed the medical records of @entity0 diagnosed with @entity6 by computed tomography from three tertiary institutes in Jeddah, Saudi Arabia. Type of management was classified as conservative and surgical. The conservative includes medical and minimally invasive procedures, such as percutaneous drainage and nephrostomy. The surgical which is nephrectomy. The outcome observed was preservation of the kidney function or @entity0 's life. RESULTS: A total of 10 @entity0 were included (9 females and 1 male), median age was 55 years and 63% were @entity1 . The most common presentation was @entity5 (100%), @entity2 (75%), and @entity3 (63%). The most common organism isolated was @entity4 . Nephrectomy was not associated with increased survival rate, while conservative management was associated with a good outcome, less morbidity (not dialysis-dependent). CONCLUSION: Nephrectomy was not associated with high survival rate. @entity0 managed conservatively had a better overall performance and better survival. This study will add to other studies, which are encouraging conservative management.

title: XXXX : Is nephrectomy warranted?

answer: @entity6


abstract: PURPOSE: @entity2 is among the most common @entity1 affecting the central nervous system. It can be difficult to determine the exact pathogen responsible for the @entity1 and @entity0 are often treated with empiric antibiotics. This study was conducted to identify the most common clinical characteristics of @entity2 in @entity0 and evaluate the diagnostic efficacy of reverse transcriptase-polymerase chain reaction (RT-PCR) for early detection of an enterovirus. METHODS: We analyzed the medical records of @entity0 admitted to Korea University Medical Center and diagnosed with @entity2 on the basis of cerebrospinal fluid (CSF) analysis and RT-PCR from CSF and other samples from January 2010 to August 2013. RESULTS: A total of 333 @entity0 were enrolled and classified into four groups based on diagnosis: @entity2 (n=110), @entity4 (n=23), other @entity3 (n=36), and unknown etiology (n=164). @entity0 with @entity4 were younger than those in the other groups (P<0.001). Pleocytosis in CSF was similar across all groups. Of @entity0 in the @entity2 group, 92.7% were diagnosed based on RT-PCR findings. Mean length of hospital stay for @entity0 with @entity2 was 6.08 days, which was significantly shorter than that for @entity0 with @entity2 of bacterial etiology (19.73 days, P<0.001). CONCLUSION: Diagnosis of @entity2 before viral culture results are available is possible using RT-PCR. Accurate diagnosis reduces the length of hospital stay and helps to avoid unnecessary empiric antibiotic treatment.

title: Analysis of clinical information and reverse transcriptase-polymerase chain reaction for early diagnosis of XXXX .

answer: @entity2


abstract: BACKGROUND: The purpose of current study is to evaluate the association between physical @entity4 level and the prevalence of @entity2 ( @entity2 ) in a Korean elderly population. METHODS: A cross-sectional study measuring physical @entity4 and components of @entity2 in a health promotion center of a general hospital for routine health check-ups. A total of 227 subjects  >60  years old agreed to participate. A lifestyle questionnaire that included cigarette smoking, @entity3 consumption, and physical activity was checked. Body weight, height, blood pressure, fasting @entity5 , total @entity1 , @entity6 , high density lipoprotein- @entity1 , low density lipoprotein- @entity1 , C-reactive protein, and glycated hemoglobin were measured. Muscular strength was assessed by measuring grasping power. Muscular endurance was evaluated using a sit-up test. Cardiopulmonary @entity4 was assessed via the Tecumseh step test (measuring hear rates at 1  min post-exercise). RESULTS: The highest tertile muscular endurance group (sit-ups  >15 in @entity0 ,  >10 in @entity0 ) was 0.37 times less likely to have @entity2 [95  % confidence interval (CI) 0.17-0.84; p  =  0.036] compared to that in the lowest tertile group (<11 in @entity0 , 0 in @entity0 ), and the highest tertile in the cardiopulmonary @entity4 group (heart rate at rest  >91/min in @entity0 ,  >92/min in @entity0 ) was 2.81 times more likely to have @entity2 (95  % CI 1.27-6.18; p  =  0.038) compared to that in the lowest tertile group (<81/min in @entity0 ,  <80/min in @entity0 ). CONCLUSIONS: Cardiopulmonary @entity4 and muscular endurance were related to @entity2 in a Korean elderly population after adjusting for age, sex, current smoker, current @entity3 drinking, and physical activity. Older adults should be encouraged to increase their cardiopulmonary @entity4 and muscular endurance.

title: The association among three aspects of physical XXXX and @entity2 in a Korean elderly population.

answer: @entity4


abstract: BACKGROUND: The purpose of current study is to evaluate the association between physical @entity4 level and the prevalence of @entity2 ( @entity2 ) in a Korean elderly population. METHODS: A cross-sectional study measuring physical @entity4 and components of @entity2 in a health promotion center of a general hospital for routine health check-ups. A total of 227 subjects  >60  years old agreed to participate. A lifestyle questionnaire that included cigarette smoking, @entity3 consumption, and physical activity was checked. Body weight, height, blood pressure, fasting @entity5 , total @entity1 , @entity6 , high density lipoprotein- @entity1 , low density lipoprotein- @entity1 , C-reactive protein, and glycated hemoglobin were measured. Muscular strength was assessed by measuring grasping power. Muscular endurance was evaluated using a sit-up test. Cardiopulmonary @entity4 was assessed via the Tecumseh step test (measuring hear rates at 1  min post-exercise). RESULTS: The highest tertile muscular endurance group (sit-ups  >15 in @entity0 ,  >10 in @entity0 ) was 0.37 times less likely to have @entity2 [95  % confidence interval (CI) 0.17-0.84; p  =  0.036] compared to that in the lowest tertile group (<11 in @entity0 , 0 in @entity0 ), and the highest tertile in the cardiopulmonary @entity4 group (heart rate at rest  >91/min in @entity0 ,  >92/min in @entity0 ) was 2.81 times more likely to have @entity2 (95  % CI 1.27-6.18; p  =  0.038) compared to that in the lowest tertile group (<81/min in @entity0 ,  <80/min in @entity0 ). CONCLUSIONS: Cardiopulmonary @entity4 and muscular endurance were related to @entity2 in a Korean elderly population after adjusting for age, sex, current smoker, current @entity3 drinking, and physical activity. Older adults should be encouraged to increase their cardiopulmonary @entity4 and muscular endurance.

title: The association among three aspects of physical @entity4 and XXXX in a Korean elderly population.

answer: @entity2


abstract: Between 1966 and 1977, 55 @entity0 at Barnes Hospital were proven to have manifestations of @entity7 . Five @entity0 had @entity1 , four of whom demonstrated unusually severe disease. Disseminated @entity7 was documented in 19 cases. Four of these @entity0 demonstrated dissemination during a severe and protracted but self-limited illness. The other 15 @entity0 had progressive disease. Most of these @entity0 were immune compromised and presented with fever of unknown origin. Therapy most benefited those who completed a course of greater than or equal to 1.5 gm of @entity6 . @entity4 was documented in 14 individuals. Large (> 1.5 cm), solitary @entity8 , excised from 14 @entity0 , were found to consist of exuberant @entity3 containing @entity2 . Organisms were recovered from pleural effusions of two @entity0 and demonstrated histologically in the tissue of one individual who presented with fibrosing @entity5 .

title: The spectrum of XXXX in a general hospital: a review of 55 cases diagnosed at Barnes Hospital between 1966 and 1977.

answer: @entity7


abstract: The acute syndromes and CT findings are described in 26 cases of spontaneous @entity11 . @entity9 (11 cases) caused severe @entity6 around the ipsilateral eye and dense @entity12 . Left temporal @entity9 (7 cases) began with mild @entity6 in or just anterior to the ear, @entity14 with poor auditory comprehension but relatively good repetition, and a @entity7 subtending less than a @entity12 . Frontal @entity9 (4 cases) caused a distinctive syndrome beginning with severe contralateral arm @entity8 , minimal leg and face @entity8 , and frontal @entity2 . @entity9 (3 cases) began with anterior temporal ("temple") @entity2 and @entity3 , sometimes involving the trunk to the midline. One @entity0 had a right temporal @entity9 . @entity9 in the same region produce similar clinical syndromes. @entity2 is a first and prominent symptom. A rapid but not instantaneous onset over several minutes, when combined with one of the typical syndromes, suggests lobar @entity9 rather than other types of @entity4 . Ancillary investigations (including CT scanning, angiography in 11 @entity0 , and autopsy in 4) disclosed 2 @entity0 with @entity9 diatheses due to @entity10 , 2 with @entity13 , and 1 with @entity1 . Only 8 of the 26 @entity0 had chronic @entity5 (blood pressure greater than 130/85 mm Hg), suggesting that @entity5 is not an etiological factor in most lobar @entity9 .

title: XXXX : acute clinical syndromes in 26 cases.

answer: @entity11


abstract: Because of joint @entity7 , severe @entity6 subjects often have limitations in their daily activities. Current orthopaedic scores (OJS) in @entity6 miss mild @entity2 and only pick up severe alterations. Twelve young severe haemophiliacs (20.25        1.9  years of age), were evaluated for OJS as well as for indices employed in @entity5 [28-joint Disease Activity Score (DAS-28), Ritchie index, Health Assessment Questionnaire (HAQ), @entity4 ( @entity4 )], @entity9 [Bath @entity9 Activity Index (BASDAI), HAQ, @entity4 ] and @entity8 [ @entity11 and @entity8 Outcome Score (KOOS), @entity4 ]. Twenty-four matched apparently healthy subjects and 29 subjects with @entity12 ( @entity12 ) with @entity13 (one to three swollen joints) served as controls. In addition to the impairment of @entity10 (elbow, in five of five in those on-demand treatment; three, elbows; four, knee in those on secondary prophylaxis), HAQ (mean 0.71        0.95) and @entity4 (3.12        2.36) documented a quality of life and a perception of @entity3 in haemophiliacs similar to that of @entity12 subjects (p   =   0.061 and p   =   0.063, respectively). Their Ritchie index did not differ from that of subjects with @entity12 (5.75        8.1 vs 7.73        9.22; p   =   0.408), nor did the BASDAI score with respect to @entity12 @entity0 (p   =   0.105). Six of 12 haemophiliacs (50%) had KOOS values from 70 to 50 (significant function @entity2 ); 3 of 12 (25%) showed DAS-28 values >3.2 (moderate disease activity), 2 of 12 (16.6%) severe disease activity (>5.1). All these indices significantly correlated with @entity4 and HAQ in @entity6 subjects. A rheumatologic assessment may help identify early @entity1 and subclinical @entity1 not usually studied (not target joint) in haemophiliacs. These pilot data provide the rationale for testing a systemic involvement in haemophiliacs by means of high-tech imaging and to start early-onset prophylaxis/treatment in this setting.

title: Assessing joint involvement in @entity6 by clinical rheumatologic scores. A pilot study on similarities with subjects with XXXX .

answer: @entity12


abstract: Because of joint @entity7 , severe @entity6 subjects often have limitations in their daily activities. Current orthopaedic scores (OJS) in @entity6 miss mild @entity2 and only pick up severe alterations. Twelve young severe haemophiliacs (20.25        1.9  years of age), were evaluated for OJS as well as for indices employed in @entity5 [28-joint Disease Activity Score (DAS-28), Ritchie index, Health Assessment Questionnaire (HAQ), @entity4 ( @entity4 )], @entity9 [Bath @entity9 Activity Index (BASDAI), HAQ, @entity4 ] and @entity8 [ @entity11 and @entity8 Outcome Score (KOOS), @entity4 ]. Twenty-four matched apparently healthy subjects and 29 subjects with @entity12 ( @entity12 ) with @entity13 (one to three swollen joints) served as controls. In addition to the impairment of @entity10 (elbow, in five of five in those on-demand treatment; three, elbows; four, knee in those on secondary prophylaxis), HAQ (mean 0.71        0.95) and @entity4 (3.12        2.36) documented a quality of life and a perception of @entity3 in haemophiliacs similar to that of @entity12 subjects (p   =   0.061 and p   =   0.063, respectively). Their Ritchie index did not differ from that of subjects with @entity12 (5.75        8.1 vs 7.73        9.22; p   =   0.408), nor did the BASDAI score with respect to @entity12 @entity0 (p   =   0.105). Six of 12 haemophiliacs (50%) had KOOS values from 70 to 50 (significant function @entity2 ); 3 of 12 (25%) showed DAS-28 values >3.2 (moderate disease activity), 2 of 12 (16.6%) severe disease activity (>5.1). All these indices significantly correlated with @entity4 and HAQ in @entity6 subjects. A rheumatologic assessment may help identify early @entity1 and subclinical @entity1 not usually studied (not target joint) in haemophiliacs. These pilot data provide the rationale for testing a systemic involvement in haemophiliacs by means of high-tech imaging and to start early-onset prophylaxis/treatment in this setting.

title: Assessing joint involvement in XXXX by clinical rheumatologic scores. A pilot study on similarities with subjects with @entity12 .

answer: @entity6


abstract: @entity5 ( @entity5 ) for @entity6 is associated with @entity3 which may be a result of damage to neural progenitor cells (NPCs). We present a novel technique to limit the radiation dose to @entity7 without compromising @entity1 coverage. A study was performed in @entity2 to examine the rationale and another was conducted in @entity0 to determine its feasibility. C57BL/6 @entity2 received localized radiation using a dedicated animal irradiation system with on-board CT imaging with either: (1) Radiation which spared @entity7 containing regions; (2) Radiation which did not spare these niches; or (3) Sham irradiation. @entity2 were sacrificed 24  h later and the brains were processed for immunohistochemical Ki-67 staining. For the @entity0 component of the study, 33 @entity0 with primary @entity6 were evaluated. Two intensity modulated radiotherapy (IMRT) plans were retrospectively compared: a standard clinical plan and a plan which spares @entity7 regions while maintaining the same dose coverage of the @entity1 . The change in radiation dose to the contralateral @entity7 -containing regions was recorded. In the @entity2 model, non- @entity7 -sparing radiation treatment resulted in a significant decrease in the number of Ki67(+) cells in dentate gyrus (DG) (P  =  0.008) and subventricular zone (SVZ) (P  =  0.005) compared to @entity7 -sparing radiation treatment. In @entity7 -sparing clinical plans, @entity7 regions received significantly lower radiation dose with no clinically relevant changes in @entity1 coverage. This novel radiation technique should significantly reduce radiation doses to @entity7 containing regions of the brain which may reduce @entity4 following @entity5 for @entity6 .

title: A radiotherapy technique to limit dose to neural progenitor cell niches without compromising XXXX coverage.

answer: @entity1


abstract: PURPOSE: The fixation and incorporation of @entity2 rotator cuff tendon to bone is a major concern in rotator cuff repair surgery. Rotator cuff repair usually fails at the tendon-bone interface, especially in case of large or massive tears. To enhance @entity0 , an injectable hydrogel made with periosteal progenitor cells(PPCs) and @entity5 ( @entity5 ) tethered with bone morphogenic protein-2( @entity6 ) was developed to encourage extracellular matrix synthesis for tendon-to-bone healing in rotator cuff repair. METHODS: The infraspinatus tendon was cut from the greater tuberosity and repaired through a transosseous tunnel with the injectable progenitor cell- @entity6 hydrogel applied between the tendon-bone interface. The injectable hydrogel was prepared from 10% @entity5 ( @entity5 ) containing 0.05% of the photoinitiator. @entity6 tethered with @entity3 ( @entity4 ) was blended to the hydrogel. @entity1 periosteal progenitor cells (PPCs) isolated from periosteum were mixed with hydrogel and injected on the tendon-bone interface. Ultraviolet radiation (365  nm) was applied for 60  s to photopolymerize the injection and solidify the hydrogel. The @entity1 were killed at 4 and 8  weeks. The morphological characteristics of the healing tendon-to-bone interface were evaluated by histological and immunohistochemical methods. The biomechanical test was done to determine healing attachment strength. RESULTS: At both the 4- and 8-week killing, histological analysis of the tendon-bone interface showed an increasing fibrocartilage and bone layer formed in the tendon-bone interface in @entity5 group. At 4  weeks, fibrocartilage-like tissue was observed in a focal area. At 8  weeks, further matrix deposition occurred with fibrocartilage formation in the @entity0 , and bone formation appeared near host bone. Immunohistochemistry revealed the presence of aggrecan and type II collagen. Biomechanical testing revealed a higher maximum pull-out load at all time points with a statistically significant difference at 4 and 8  weeks postoperatively. CONCLUSION: @entity5 hydrogel was approved as an adequate matrix for the encapsulation of cells and signal factor, and as an effective local delivery method to the tendon-bone interface through injection and photopolymerization. The PPCs- @entity6 -hydrogel provides a powerful inductive ability between the tendon and the bone and enhances @entity0 through the neoformation of fibrocartilage.

title: Enhancement of rotator cuff @entity0 with injectable periosteum progenitor cells- XXXX hydrogel in vivo.

answer: @entity6


abstract: PURPOSE: The fixation and incorporation of @entity2 rotator cuff tendon to bone is a major concern in rotator cuff repair surgery. Rotator cuff repair usually fails at the tendon-bone interface, especially in case of large or massive tears. To enhance @entity0 , an injectable hydrogel made with periosteal progenitor cells(PPCs) and @entity5 ( @entity5 ) tethered with bone morphogenic protein-2( @entity6 ) was developed to encourage extracellular matrix synthesis for tendon-to-bone healing in rotator cuff repair. METHODS: The infraspinatus tendon was cut from the greater tuberosity and repaired through a transosseous tunnel with the injectable progenitor cell- @entity6 hydrogel applied between the tendon-bone interface. The injectable hydrogel was prepared from 10% @entity5 ( @entity5 ) containing 0.05% of the photoinitiator. @entity6 tethered with @entity3 ( @entity4 ) was blended to the hydrogel. @entity1 periosteal progenitor cells (PPCs) isolated from periosteum were mixed with hydrogel and injected on the tendon-bone interface. Ultraviolet radiation (365  nm) was applied for 60  s to photopolymerize the injection and solidify the hydrogel. The @entity1 were killed at 4 and 8  weeks. The morphological characteristics of the healing tendon-to-bone interface were evaluated by histological and immunohistochemical methods. The biomechanical test was done to determine healing attachment strength. RESULTS: At both the 4- and 8-week killing, histological analysis of the tendon-bone interface showed an increasing fibrocartilage and bone layer formed in the tendon-bone interface in @entity5 group. At 4  weeks, fibrocartilage-like tissue was observed in a focal area. At 8  weeks, further matrix deposition occurred with fibrocartilage formation in the @entity0 , and bone formation appeared near host bone. Immunohistochemistry revealed the presence of aggrecan and type II collagen. Biomechanical testing revealed a higher maximum pull-out load at all time points with a statistically significant difference at 4 and 8  weeks postoperatively. CONCLUSION: @entity5 hydrogel was approved as an adequate matrix for the encapsulation of cells and signal factor, and as an effective local delivery method to the tendon-bone interface through injection and photopolymerization. The PPCs- @entity6 -hydrogel provides a powerful inductive ability between the tendon and the bone and enhances @entity0 through the neoformation of fibrocartilage.

title: Enhancement of rotator cuff XXXX with injectable periosteum progenitor cells- @entity6 hydrogel in vivo.

answer: @entity0


abstract: Ambulatory monitoring of the electrocardiogram was performed in 131 healthy @entity0 aged between 10 and 13 years for two consecutive periods of 24 hours. When awake the maximal heart rates ranged from 100 to 200 and the minimal from 45 to 80 beats per minute. During sleep maximal rates were 60 to 110 beats and minimal rates 30 to 70 beats per minute. @entity5 was seen in every @entity0 and in 36 (27.5%) no other changes were found. @entity1 , Mobitz type I, was not seen. @entity1 , Mobitz @entity4 , occurred twice only. Complete @entity1 occurred in 8.4 per cent, never lasted more than one cycle, and was always followed by a junctional beat. First degree @entity2 occurred in 8.4 per cent and Mobitz type I @entity2 in 10.7 per cent. Premature beats were always single, atrial in 13 per cent, ventricular in 26 per cent, and except in two @entity0 were never more than four in 24 hours. There were no episodes of @entity3 . Changes in P wave morphology were common and slow junctional rhythm occurred in 13 per cent during sleep.

title: Results of 24 hour ambulatory monitoring of electrocardiogram in 131 healthy XXXX aged 10 to 13 years.

answer: @entity0


abstract: Two-dimensional echocardiography at rest was used to analyze segmental wall motion abnormalities for detecting @entity2 in @entity0 with and without a history of @entity3 . One hundred twenty-five echocardiograms were analyzed in a randomized, blinded fashion. They were obtained from 55 consecutive @entity0 found to have significant @entity2 at angiography, 59 consecutive normal subjects and 11 @entity0 with @entity1 . The overall sensitivity of two-dimensional echocardiography was relatively low at 67%. However, specificity was 99%. The sensitivity was higher in @entity0 with past @entity3 than in those without @entity3 (81 versus 42%), as expected. Echocardiography can detect segmental wall motion abnormalities in some @entity0 with @entity2 and no overt prior @entity3 . This was highlighted by nine such @entity0 with @entity2 and no prior @entity3 or electrocardiographic Q waves who were found to have segmental wall motion abnormalities. A semiquantitative, two-dimensional echocardiographic segmental wall motion score was derived for 47 @entity0 and was correlated with angiographic left ventricular ejection fraction (r = 0.71). This score differentiated @entity0 with a normal ejection fraction (greater than 50%) from those with a depressed ejection fraction (less than 50%): 1.1 +/- 1.6 versus 6.9 +/- 3.1 (p less than 0.001). Almost all @entity0 (92%) with an echocardiographic score of five or more had an abnormal ejection fraction of less than 50%. In @entity0 with chronic @entity4 , the echocardiogram separated those with @entity1 from those with @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Value of two-dimensional echocardiography in evaluating XXXX : a randomized blinded analysis.

answer: @entity2


abstract: In the therapy of primary @entity2 in which the @entity1 is located in one ovary, radical operation including the uterus and contralateral ovary is performed in principle even in the case of young @entity0 . However, there have been only a few results reported on the primary cases in our country, and the radical operation is adopted at present in line with western policy. In the present study, the authors examined mainly the prognosis of 49 @entity0 with primary @entity2 (stage Ia, 25 cases; stage Ib, 2 cases; stage Ic, 22 cases), and the following results were obtained. Among 25 cases at stage Ia, the radical operation was performed on 14 cases, and only the conservative operation was performed on the remaining 11 cases. All of the latter are still well. Only one died among @entity0 at stage Ia. Therefore, in these cases, complete treatments were done, including radical operation, postoperative irradiation and chemotherapy, and second look operation. The prognosis of the @entity0 at Ic was worse than that at IIa + b. Therefore, it was felt to be necessary to treat them as progressive @entity1 . There was no difference between the prognoses of the conservative and radical operations even at stage Ic. Thus, problems such as functional maintenance were thought to be taken into consideration. Risk factors considered were tissue type, amount of @entity3 , capsular rhexis, and advanced age, etc. Since the prognosis after the second look operation was good, it was considered to be a treatment which should be introduced actively, even at stage I.

title: [Assessment of cases with XXXX stage I].

answer: @entity2