abstract: BACKGROUND: @entity2 ( @entity2 ) response to guideline-directed medical therapy (GDMT) and to early cardiac resynchronization therapy (CRT) in new-onset @entity0 ( @entity0 ) and @entity1 ( @entity1 ) is not well described. CRT is recommended if @entity2 remains  <=35% after at least 3 months of GDMT. OBJECTIVE: The purpose of this study was to describe @entity2 response to GDMT at 3 months and to early CRT in new-onset @entity1 -associated idiopathic @entity0 . METHODS: A retrospective cohort study was performed in subjects with new-onset idiopathic @entity0 , @entity2  <=35%, and @entity1 or narrow (<120 ms) QRS complex morphology. @entity2 response between groups was evaluated with log-binomial and linear regression. @entity2 response within groups was evaluated using the paired Student t test. RESULTS: In 102 subjects (70 with narrow QRS complex and 32 with @entity1 ), post-GDMT @entity2 was >35% in 39 narrow QRS complex subjects (56%) and 2 @entity1 subjects (6%) (P < .0001). The absolute difference between post-GDMT @entity2 and initial @entity2 was greater in the narrow QRS complex group (16.1%    14.6% vs 3.3%    10.7%; P < .0001). Narrow QRS complex, referenced to @entity1 , was significantly associated with post-GDMT @entity2 >35% (relative risk 10.30; 95% confidence interval 2.63-40.27; P = .0008) and absolute difference between post-GDMT @entity2 and initial @entity2 (b = 16.296; standard error = 2.977; P < .0001) in final multivariable analyses. CRT super-response, defined as post-CRT @entity2 >= 50%, was observed in 8 of @entity1 subjects (35%) who received CRT. CONCLUSION: GDMT did not significantly improve @entity2 in new-onset @entity1 -associated idiopathic @entity0 at 3 months. Most remained candidates for CRT, and a high percentage were super-responders. Optimal timing for CRT implantation requires further investigation.

title: New-onset @entity1 -associated XXXX and left ventricular ejection fraction response to guideline-directed therapies: The NEOLITH study.

answer: @entity0


abstract: BACKGROUND: @entity2 ( @entity2 ) response to guideline-directed medical therapy (GDMT) and to early cardiac resynchronization therapy (CRT) in new-onset @entity0 ( @entity0 ) and @entity1 ( @entity1 ) is not well described. CRT is recommended if @entity2 remains  <=35% after at least 3 months of GDMT. OBJECTIVE: The purpose of this study was to describe @entity2 response to GDMT at 3 months and to early CRT in new-onset @entity1 -associated idiopathic @entity0 . METHODS: A retrospective cohort study was performed in subjects with new-onset idiopathic @entity0 , @entity2  <=35%, and @entity1 or narrow (<120 ms) QRS complex morphology. @entity2 response between groups was evaluated with log-binomial and linear regression. @entity2 response within groups was evaluated using the paired Student t test. RESULTS: In 102 subjects (70 with narrow QRS complex and 32 with @entity1 ), post-GDMT @entity2 was >35% in 39 narrow QRS complex subjects (56%) and 2 @entity1 subjects (6%) (P < .0001). The absolute difference between post-GDMT @entity2 and initial @entity2 was greater in the narrow QRS complex group (16.1%    14.6% vs 3.3%    10.7%; P < .0001). Narrow QRS complex, referenced to @entity1 , was significantly associated with post-GDMT @entity2 >35% (relative risk 10.30; 95% confidence interval 2.63-40.27; P = .0008) and absolute difference between post-GDMT @entity2 and initial @entity2 (b = 16.296; standard error = 2.977; P < .0001) in final multivariable analyses. CRT super-response, defined as post-CRT @entity2 >= 50%, was observed in 8 of @entity1 subjects (35%) who received CRT. CONCLUSION: GDMT did not significantly improve @entity2 in new-onset @entity1 -associated idiopathic @entity0 at 3 months. Most remained candidates for CRT, and a high percentage were super-responders. Optimal timing for CRT implantation requires further investigation.

title: New-onset XXXX -associated @entity0 and left ventricular ejection fraction response to guideline-directed therapies: The NEOLITH study.

answer: @entity1


abstract: OBJECTIVE: To investigate the prevalence and clinical correlation of antiphospholipid antibodies in @entity5 . METHODS: Antibodies against cardiolipin (aCL) or beta(2)-glycoprotein I were examined by enzyme linked immunosorbent assay (ELISA) in 48 @entity0 with @entity5 (18 @entity0 with @entity8 , 20 with @entity5 , and 10 with morphoea). Twenty one of these @entity0 were investigated for @entity7 ( @entity7 ) by screening and @entity6 tests. RESULTS: @entity0 with @entity8 , the severest form of @entity5 , had significantly raised levels of IgM or IgG aCL relative to normal controls (n=21) and @entity0 with @entity3 (n=20). The IgM isotype was predominant, with the frequency of IgM aCL (61%) higher than that of IgG aCL (28%). Levels of aCL were similar for @entity0 with @entity5 or morphoea and normal controls. IgM aCL were associated with a greater number of lesions, especially @entity1 , wider distribution of lesions, and the presence of immunological abnormalities including antinuclear antibodies, rheumatoid factor, IgM antihistone antibodies, IgG anti-single stranded DNA antibodies, and raised serum @entity2 levels in @entity0 with @entity5 . @entity7 was detected in 5/7 (71%) @entity0 with @entity8 . However, @entity4 was seen in only one @entity0 with @entity8 . None of @entity0 with @entity5 exhibited anti-beta(2)-glycoprotein I antibodies. CONCLUSIONS: These results suggest that aCL and @entity7 are the major autoantibodies in @entity0 with @entity8 .

title: Antiphospholipid antibody in XXXX .

answer: @entity5


abstract: HYPOTHESIS: A transgastric approach may be used succesfully for the treatment of @entity4 presenting with @entity3 . METHODS: Eight @entity0 were admitted during a 6-year period with acute massive @entity2 caused by @entity4 . All @entity0 had signs of profound @entity5 , and initial endoscopic control was achieved in 3 @entity0 . They all underwent surgery after endoscopy. At operation, the @entity4 was approached through an anteromedial gastrostomy and hemostasis was achieved by transfixing stitches. Ulcers were excised whenever possible, or excluded if adherent posteriorly. Four-quadrant biopsy was taken for frozen section to exclude @entity1 . Both anterior and posterior gastric walls were then closed with nonabsorbable suture material. RESULTS: There were 6 @entity0 and 2 @entity0 with a mean age of 73 years. Hemoglobin levels ranged from 5.2 to 8.0 g/dL. Five @entity0 underwent emergency surgery within 28 hours of admission. The diameter of the @entity4 ranged from 2 to 5 cm. Ulcerectomy was performed in 6 cases. In the remaining 2 @entity0 , the crater of the @entity4 was adherent to the diaphragm and required exclusion from the gastrointestinal tract. None of the @entity4 proved to be malignant, and there were no operative deaths. @entity0 were followed up for a mean of 3 years with no complications. CONCLUSIONS: Satisfactory results can be achieved with a transgastric approach to these rare @entity4 . This allows definitive treatment while avoiding major gastric resection with its potential complications.

title: Transgastric surgery for XXXX : a minimal and safe approach.

answer: @entity4


abstract: HYPOTHESIS: Ultrasound-guided vacuum-assisted biopsy (UGVAB) can serve as an efficient tool for the diagnosis and excision of @entity0 . DESIGN: @entity1 with a clinically and radiographically suspected @entity0 were prospectively referred for UGVAB to confirm the diagnosis and to attempt to excise the lesion. @entity1 : Fifty-two female @entity1 , aged 19 to 68 years, were included in the 2-year study. All had at least 1 suspected @entity3 . The procedure was performed for a total of 56 lesions. INTERVENTIONS: Imaging modalities prior to biopsy to confirm the clinical suspicion included Doppler ultrasound and mammography or Doppler ultrasound alone. Tumor size and volume were recorded. Ultrasound-guided vacuum-assisted biopsy was performed in all cases, with guidance using the 11-gauge Mammotome handheld vacuum-assisted biopsy system (Ethicon Endo-Surgery Inc, Cincinnati, Ohio). MAIN OUTCOME MEASURES: Major end points included diagnosis compatibility rate, excision rate, complications, and short-term follow-up. RESULTS: A tissue diagnosis was obtained in all cases and was compatible with the clinical diagnosis of @entity3 . Complete excision was achieved in all lesions less than or equal to 1.5 cm (mean volume, 0.25 mL). All lesions greater than 2 cm (mean volume, 1 mL) were incompletely excised. Of the 20 lesions measuring 1.5 to 2.0 cm, 11 (55%) were completely excised. The volume of all completely excised lesions was less than 0.9 mL. Four lesions with a volume less than 0.9 mL were incompletely excised due to @entity2 . Ten of the 13 cases with incomplete excision were confident enough with the diagnosis to choose imaging follow-up instead of surgery. Two @entity1 (16%) were referred by the radiologist for surgical excision. Only 1 @entity1 with incomplete removal (8%) felt uncomfortable with the remnant lump and requested surgical excision. CONCLUSIONS: Although the @entity0 is a common @entity0 , the treatment and follow-up of these lesions is still debatable. We suggest that UGVAB, which has a well-documented role in the diagnosis of @entity4 , may provide an option for the definitive treatment of @entity0 .

title: Diagnosis and treatment of XXXX by ultrasound-guided vacuum-assisted biopsy.

answer: @entity0


abstract: BACKGROUND: If most adults with @entity1 are found to have a juvenile psychiatric history, this would shift etiologic research and prevention policy to focus more on childhood @entity1 . METHOD: Our prospective longitudinal study followed up a representative birth cohort (N = 1037). We made psychiatric diagnoses according to DSM criteria at 11, 13, 15, 18, 21, and 26 years of age. @entity0 were defined in the following 3 ways: (1) cases diagnosed using a standardized diagnostic interview, (2) the subset using treatment, and (3) the subset receiving intensive mental health services. Follow-back analyses ascertained the proportion of adult cases who had juvenile diagnoses and the types of juvenile diagnoses they had. RESULTS: Among adult cases defined via the Diagnostic Interview Schedule, 73.9% had received a diagnosis before 18 years of age and 50.0% before 15 years of age. Among treatment-using cases, 76.5% received a diagnosis before 18 years of age and 57.5% before 15 years of age. Among cases receiving intensive mental health services, 77.9% received a diagnosis before 18 years of age and 60.3% before 15 years of age. @entity0 were generally preceded by their juvenile counterparts (eg, adult @entity2 was preceded by juvenile @entity2 ), but also by different disorders. Specifically, adult @entity2 and @entity3 were preceded by a broad array of @entity0 . For all adult disorders, 25% to 60% of cases had a history of conduct and/or @entity4 . CONCLUSIONS: Most adult disorders should be reframed as extensions of @entity0 . In particular, @entity5 is a priority prevention target for reducing @entity1 in the adult population.

title: Prior juvenile diagnoses in adults with XXXX : developmental follow-back of a prospective-longitudinal cohort.

answer: @entity1


abstract: X-ray crystallographic studies of the @entity1 fragments of two murine monoclonal antibodies of predefined specificity are under way. Diffracted X-ray intensities of the crystalline native @entity1 fragment of an anti- @entity2 antibody and of three heavy atom derivatives have been measured to a resolution of 3.5 A. A preliminary 6-A resolution electron density map has been obtained. The 6-A resolution structure of an antigen-antibody (hen lysozyme- @entity1 ) complex has been determined. There are close contacts between the antigen and the antibody over a large contact area, about 20 @entity3 . At least two segments of the polypeptide chain of lysozyme, of about 10 amino acids each (positions 19-27 and 116-129), are involved in the contacts, as well as all six complementarity-determining regions of the antibody. No gross conformational changes are observed in the antigen at this resolution, although there are some smaller local changes in areas in contact with the antibody and elsewhere. The effects of @entity0 substitutions on antigen recognition by the monoclonal anti-hen lysozyme antibody were investigated using different, closely related lysozymes. These effects can be readily explained in terms of the three-dimensional model presented here. A 3.5-A resolution electron density map has been calculated and is currently under study.

title: X-ray diffraction studies of an anti- XXXX antibody and of an antigen-antibody complex.

answer: @entity2


abstract: INTRODUCTION: @entity3 ( @entity3 ) are an uncommon complication following radical prostatectomy. Occasionally, BNCs can be refractory to endoscopic approaches. We describe the effectiveness of a novel robotic-assisted laparoscopic catheterizable bladder augment in treating recalcitrant BNCs. MATERIALS AND METHODS: @entity0 undergoing robotic-assisted radical prostatectomy (RALP) between 2004-2014 who developed a postoperative @entity3 were identified. We documented our experience with robotic-assisted laparoscopic catheterizable bladder augment for recalcitrant BNCs. Total operative time, robotic time, estimated surgical blood, length of hospital stay, serum @entity2 , complications, and postoperative course/upper tract imaging were recorded. RESULTS: Thirty-six of 2002 RALP @entity0 (1.8%) experienced a post-surgical @entity3 at 182 days post-surgery. Twenty-two (61.1%) underwent a single dilation and/or transurethral incision. Eleven (30.6%) required = 1 procedure. Three @entity0 (8.3%) had recalcitrant BNCs. One @entity0 with normal bladder capacity elected open urethroplasty. The remaining two had @entity3 , detrusor over-activity and failed multiple incisions and self-catheterization. In one @entity0 , the stricture was complete. The other @entity0 experienced urethral leakage requiring bladder neck closure. In both @entity0 , a robotic approach, utilizing an ileal-cecal segment as a catheterizable augment, was performed. At 16 and 89 months follow up, both are continent, with stable renal function and normal upper tracts. CONCLUSION: Robotic-assisted laparoscopic catheterizable bladder augment is a viable treatment for recurrent BNCs. This approach may be particularly well suited for @entity0 with concurrent @entity1 or decreased bladder capacity.

title: Robotic-assisted laparoscopic catheterizable bladder augment: a novel approach to treat recurrent XXXX following radical prostatectomy.

answer: @entity3


abstract: OBJECTIVE: To determine the feasibility, reliability and validity of nails ultrasonography in @entity7 as an outcome measure. METHODS: Pilot prospective single-centre study of eight ultrasonography parameters in B mode and power Doppler concerning the @entity3 ( @entity3 ) joint, the matrix, the bed and nail plate. Intra-observer and inter-observer reliability was evaluated for the seven quantitative parameters ( @entity8 and kappa). Correlations between ultrasonography and clinical variables were searched to assess external validity. Feasibility was assessed by the time to carry out the examination and the percentage of missing data. RESULTS: Twenty-seven @entity0 with @entity7 (age 55.0  16.2 years, disease duration 13.4  9.4 years) were included. Of these, 67% presented nail involvement on ultrasonography vs 37% on physical examination (P<0.05). Reliability was good ( @entity8 and weighted kappa>0.75) for the seven quantitative parameters, except for @entity4 of the @entity3 joint in B mode. The @entity4 of the @entity3 joint revealed by ultrasonography correlated with the total number of clinical @entity4 and Doppler US of the nail (matrix and bed). Doppler US of the matrix correlated with @entity2 but not with the @entity5 or with clinical @entity6 . No significant correlation was found with US nail thickness. CONCLUSION: The feasibility and reliability of ultrasonography of the nail in @entity7 appear to be satisfactory. Among the eight parameters evaluated, power Doppler of the matrix which correlated with @entity1 ( @entity3 joint and bed) and with @entity2 could become an interesting outcome measure, provided that it is also sensitive to change.

title: Reliability, validity and feasibility of nail ultrasonography in XXXX .

answer: @entity7


abstract: BACKGROUND: Gout is the most common cause of @entity3 in @entity0 aged >40 years and is frequently encountered in clinical practice. OBJECTIVE: The goal of this article was to review the published literature on the epidemiology, treatment, and estimated burden of illness of @entity4 . METHODS: Articles on @entity1 published in English between 1980 and June 2002 were identified through a MEDLINE search. Relevant clinical studies and review articles were found using the text- and keyword-search term @entity1 alone and in combination with epidemiology, prevalence, incidence, complications, outcome, quality of life, economics, cost, prevention or drug therapy. The reference lists of identified articles, especially review articles, were checked for any additional studies that might have been missed in the original MEDLINE search. RESULTS: The epidemiology of @entity1 in various geographic regions has been well documented. Data suggest that environmental, racial, and hereditary factors may influence the development of @entity1 , and that the prevalence of @entity1 appears to be on the rise worldwide. Evidence from well-designed clinical studies evaluating drug therapies for @entity1 is limited. Therapies for @entity4 include corticotropin, @entity2 , @entity5 or, more often, nonsteroidal anti-inflammatory drugs (NSAIDs), which have shown comparable efficacy. A recent study suggests that @entity6 , a new cyclooxygenase-2-selective inhibitor, may be as effective as and better tolerated than traditional NSAIDs in the treatment of @entity1 . Urate-lowering therapy, prophylactic @entity5 , and low-dose NSAIDs are used for the long-term prophylaxis of @entity1 . However, all acute and prophylactic therapies are associated with adverse events. Using an economic model for @entity1 , the annual direct burden of illness for new cases of @entity4 can be estimated at 27,378,494 US dollars in the United States. CONCLUSIONS: Gout is an increasingly prevalent condition worldwide and creates a heavy economic burden. Available treatments are generally effective; however, they are not devoid of adverse events. Well-designed, long-term, controlled clinical trials evaluating the comparative efficacy and tolerability of treatments for @entity1 are needed.

title: A literature review of the epidemiology and treatment of XXXX .

answer: @entity4


abstract: BACKGROUND: Overweight and @entity1 are epidemic in Western societies and constitute a major public health problem because of adverse effects on vascular health. Vascular factors may play a role in the development of a rapidly growing disease of late life, @entity4 ( @entity4 ). Using body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), we examined whether overweight is a risk factor for @entity5 and @entity4 . METHODS: The relationship between BMI and @entity5 risk was investigated in a representative cohort of 392 nondemented Swedish adults who were followed up from age 70 to 88 years, with the use of neuropsychiatric, anthropometric, and other measurements. Multivariate Cox proportional hazards regression analyses included BMI, blood pressure, @entity2 , cigarette smoking, socioeconomic status, and treatment for @entity3 . RESULTS: During the 18-year follow-up (4184.8 risk-years), 93 @entity0 were diagnosed as having @entity5 . @entity0 who developed @entity5 between ages 79 and 88 years were overweight, with a higher average BMI at age 70 years (27.7 vs 25.7; P =.007), 75 years (27.9 vs 25.0; P<.001), and 79 years (26.9 vs 25.1; P =.02) compared with nondemented @entity0 . A higher degree of overweight was observed in @entity0 who developed @entity4 at 70 years (29.3; P =.009), 75 years (29.6; P<.001), and 79 years (28.2; P =.003) compared with nondemented @entity0 . For every 1.0 increase in BMI at age 70 years, @entity4 risk increased by 36%. These associations were not found in @entity0 . CONCLUSIONS: Overweight is epidemic in Western societies. Our data suggest that overweight at high ages is a risk factor for @entity5 , particularly @entity4 , in @entity0 . This may have profound implications for @entity5 prevention.

title: An 18-year follow-up of overweight and risk of XXXX .

answer: @entity4


abstract: BACKGROUND: @entity2 ( @entity2 ) is a debilitating illness with no known cause or effective therapy. Population-based epidemiologic data on @entity2 prevalence and incidence are critical to put @entity2 in a realistic context for public health officials and others responsible for allocating resources and for practicing physicians when examining and caring for @entity0 . METHODS: We conducted a random digit-dialing survey and clinical examination to estimate the prevalence of @entity2 in the general population of Wichita, Kan, and a 1-year follow-up telephone interview and clinical examination to estimate the incidence of @entity2 . The survey included 33 997 households representing 90 316 residents. This report focuses on 7162 respondents aged 18 to 69 years. Fatigued (n = 3528) and randomly selected nonfatigued (n = 3634) respondents completed telephone questionnaires concerning fatigue, other symptoms, and medical history. The clinical examination included the Diagnostic Interview Schedule for Diagnostic and Statistical Manual of @entity1 , Fourth Edition, laboratory testing, and a physical examination. RESULTS: The overall weighted point prevalence of @entity2 , adjusted for nonresponse, was 235 per 100,000 @entity0 (95% confidence interval, 142-327 per 100,000 @entity0 ). The prevalence of @entity2 was higher among @entity0 , 373 per 100,000 @entity0 (95% confidence interval, 210-536 per 100,000 @entity0 ), than among @entity0 , 83 per 100,000 @entity0 (95% confidence interval, 15-150 per 100,000 @entity0 ). Among subjects nonfatigued and fatigued for less than 6 months, the 1-year incidence of @entity2 was 180 per 100,000 @entity0 (95% confidence interval, 0-466 per 100,000 @entity0 ). CONCLUSIONS: @entity2 constitutes a major public health problem. Longitudinal follow-up of this cohort will be used to further evaluate the natural history of this illness.

title: Prevalence and incidence of XXXX in Wichita, Kansas.

answer: @entity2


abstract: Supramaximal flow transients of partial expiratory flow-volume curves are caused by a rapidly emptying compartment. By superimposing a maximal and a series of partial expiratory flow-volume curves, the volume of the flow transient equivalent for the maximal curve was estimated (volume of airway contribution = VACMEFV). This flow transient equivalent is caused by an extra dead space, created in the large airways by a full inspiration. In 18 @entity0 with @entity1 ( @entity1 ), routine pulmonary functions and VACMEFV were measured before and after bronchodilator medication. Baseline VACMEFV correlated directly with the curvilinearity of the flow-volume curve and inversely with the clinical and radiologic score. Significantly, bronchodilator medication improved FVC, FEV1, FEF25-75, VC, PEF, Raw, and also VACMEFV. In 6 @entity0 , VEmax25 increased as a result of apparent peripheral bronchodilation. In 3 others, end-expiratory flow increased slightly but the expanded VACMEFV included the measuring point invalidating the measurement. In the remaining 9 @entity0 , VEmax25 decreased after bronchodilator. As an apparent discrepancy, FEV1, FVC, PEF, VC, FEF25-75 increased, and Raw decreased in 4 to 9 @entity0 . The volumes and flow rates measured early in forced expiration and the end-expiratory flow behaved differently because VACMEFV expanded beyond the measuring points of early expiratory and mid-expiratory flow rates. As the bronchodilator rendered the compliant large airways still more distensible, the amount of air emptied from the dead space in early forced expiration increased. Simultaneously, end-expiratory flow decreased because of enhanced airway compression.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Bronchodilators increase airway instability in XXXX .

answer: @entity1


abstract: PURPOSE: To perform a systematic review and meta-analysis of all published studies since 2005 that evaluate the accuracy of magnetic resonance imaging (MRI) for the diagnosis of @entity1 in the general population presenting to emergency departments. MATERIALS AND METHODS: All retrospective and prospective studies evaluating the accuracy of MRI to diagnose @entity2 published in English and listed in PubMed, Web of Science, Cinahl Plus, and the Cochrane Library since 2005 were included. Excluded studies were those without an explicitly stated reference standard, with insufficient data to calculate the study outcomes, or if the population enrolled was limited to pregnant @entity0 or @entity0 . Data were abstracted by one investigator and confirmed by another. Data included the number of true positives, true negatives, false positives, false negatives, number of equivocal cases, type of MRI scanner, type of MRI sequence, and demographic data including study setting and gender distribution. Summary test characteristics were calculated. Forest plots and a summary receiver operator characteristic plot were generated. RESULTS: Ten studies met eligibility criteria, representing @entity0 from seven countries. Nine were prospective and two were multicenter studies. A total of 838 subjects were enrolled; 406 (48%) were @entity0 . All studies routinely used unenhanced MR images, although two used intravenous contrast-enhancement and three used diffusion-weighted imaging. Using a bivariate random-effects model the summary sensitivity was 96.6% (95% confidence interval [CI]: 92.3%-98.5%) and summary specificity was 95.9% (95% CI: 89.4%-98.4%). CONCLUSION: MRI has a high sensitivity and specificity for the diagnosis of @entity2 , similar to that reported previously for computed tomography. J. Magn. Reson. Imaging 2015.

title: Systematic review and meta-analysis of the accuracy of MRI to diagnose XXXX in the general population.

answer: @entity2


abstract: SNPs, abundant in @entity0 genome with lower mutation rate, are attractive to genetic application like forensic, anthropological and evolutionary studies. Universal SNPs showing little allelic frequency variation among populations while remaining highly informative for @entity0 identification were obtained from previous studies. However, genotyping tools target only dozens of markers simultaneously, limiting their applications. Here, 124 SNPs were simultaneous tested using Ampliseq technology with Ion Torrent PGM platform. Concordance study was performed with 2 reference samples of 9947A and 9948 between NGS and Sanger sequencing. Full concordance were obtained except genotype of @entity2 with 9947A. Parameter of FMAR (%) was introduced for NGS data analysis for the first time, evaluating allelic performance, sensitivity testing and mixture testing. FMAR values for accurate heterozygotes should be range from 50% to 60%, for homozygotes or Y-SNP should be above 90%. SNPs of @entity3 , @entity4 , @entity5 , @entity6 , @entity7 , @entity2 and @entity8 were recognized as poorly performing loci, either with @entity1 or with lower coverage. Sensitivity testing demonstrated that with DNA range from 10   ng-0.5   ng, all correct genotypes were obtained. For mixture testing, a clear linear correlation (R(2)   =   0.9429) between the excepted FMAR and observed FMAR values of mixtures was observed.

title: Parallel Analysis of 124 Universal SNPs for XXXX Identification by Targeted Semiconductor Sequencing.

answer: @entity0


abstract: Normal and antibiotic-pretreated staphylococci were incubated with @entity0 neutrophils to determine the interactions between cells and antimicrobials in the killing of the organisms. @entity2 502A pretreated during log-phase growth with subinhibitory ((1/4) minimum inhibiting concentration) (MIC) concentrations of @entity6 were more susceptible to killing by normal neutrophils than untreated bacteria (intracellular survival 0.17+/-0.04 vs. 1.5+/-0.38%, mean+/-SEM, respectively, at 35 min in 14 experiments; P < 0.01 by t test). Furthermore, this enhanced susceptibility to killing was observed even when phagosome formation was inhibited by @entity5 (65.6+/-4.6% pencillintreated vs. 30.5+/-4.5% untreated killed at 30 min in 14 experiments, P < 0.001). Pretreatment of @entity2 with @entity4 similarly enhanced susceptibility to killing by @entity5 -treated polymorphonuclear leukocytes (PMN), whereas pretreatment with @entity3 did not. The enchancement of killing by pretreatment with cell wall-active antibiotics was present in a dose-response fashion to 1/16th the MIC. It required specific antimicrobial activity; i.e., @entity1 activity was inhibited by penicillinase or by incubation with bacteria at 4 degrees C. It also required active cellular metabolism and intact neutrophils. For antibiotic-pretreated bacteria to be killed by normal and @entity5 -treated cells, phagocytosis or binding to the cells was essential via a serum opsonindependent mechanism. In experiments with the @entity5 -treated cells, all bound @entity1 -treated bacteria were killed vs. only a fraction (70%) of the bound untreated bacteria. @entity1 in 10 times the MIC had no direct effects on PMN phagocytic, metabolic, or microbicidal functions against a nonsusceptible organism, @entity7 . The results indicate a cooperative effect between cell wall-active antibiotics at low concentrations and @entity0 PMN in the killing of staphylococci. The model establishes conditions for the study of the mechanisms involved in the cooperation of these bactericidal systems.

title: Interactions between antibiotics and XXXX neutrophils in the killing of staphylococci.

answer: @entity0


abstract: Records of black (predominantly Zulu), Indian and white @entity0 admitted to hospital for elective evaluation of chronic @entity11 over a 2-year interval were examined. The @entity4 encountered in all three groups was @entity9 , although @entity10 occurred more frequently in blacks. While @entity9 of the lower extremities showed minor differences in distribution in the three groups, @entity8 was more frequent in the @entity2 . @entity7 was also less prevalent among blacks. Age and sex distribution was similar. In a subset of @entity0 , matched for age, with aorto-iliac occlusive disease blacks had a statistically significantly lower incidence of @entity6 , @entity3 and @entity5 than whites or Indians; and smoked less. @entity1 had a significantly higher incidence in Indians. Within the same group of @entity0 , blacks tended to present at a more advanced stage in the natural history of the disease. However, early and medium-term results of aortobifemoral bypass are not significantly different from those in whites or Indians. @entity9 , contrary to popular belief, is a well-established clinical problem in the black population in Natal.

title: XXXX in blacks--an established problem.

answer: @entity11


abstract: @entity5 was isolated from 3.5% of 202 @entity0 , 12.5% of 120 @entity1 , 16% of 106 sparrows (Zonotrichia capensis), and from 54% of 50 @entity4 from Costa Rica. The infection rate in @entity4 increased from 23% in those weighing less than 500 g, to 73% in those between 500 and 1,000 g, indicating a rapid rate of acquiring infectin, probably from the soil in which they constantly search for food. No isolates were made from Musca domestica, or from four genera of roaches caught in the wild. However, @entity5 was isolated from four of 16 lots of earthworms. Most strains of @entity5 isolated from Costa Rican @entity3 produced chronic @entity2 in @entity0 . However, even when infected with virulent strains, @entity0 died at a time when numerous bradyzoites had been formed. Also, the availability of bradyzoites in @entity4 8-10 days after ingestion of oocysts was comparable to that in @entity0 . Therefore, several infected prey species are available as intermediate hosts to @entity3 , providing the bradyzoites essential for the shedding of large numbers of oocysts. The isolation of @entity5 from earthworms or the soil associated with them illustrates their possible role as transport hosts to infect @entity4 and other birds feeding on them. The possible role of other transport hosts could not be confirmed.

title: Intermediate and transport hosts of XXXX in Costa Rica.

answer: @entity5


abstract: MicroRNAs are small (~22 nt), noncoding RNA molecules that have critical cellular functions in proliferation, differentiation, angiogenesis and apoptosis. miRNA expression profiling has been used to create signatures of @entity1 and, in many cases, it has been shown to correlate with the severity of the disease. The @entity2 VX2 @entity1 model has been used widely to study a number of @entity0 @entity1 . Our objective in this study is to generate an miRNA signature of the VX2 @entity1 and to identify miRNAs that are highly expressed in this @entity3 . In this study, we performed miRNA profiling of the @entity2 VX2 @entity1 using a microarray that has probes for 1292 unique miRNAs. Their expression in @entity1 samples was quantified and analyzed. We found that 35 miRNAs were significantly up-regulated in the VX2 @entity1 . Among these, 13 @entity0 miRNAs and eight members of the let-7 family were previously identified in @entity1 . In addition, we show that the expression of three miRNAs (miR-923, miR-1275, and miR-1308) is novel for the @entity2 VX2 @entity1 , and their expression was not previously shown to be associated with any type of @entity1 . For the first time, we show the miRNA signature profile for a solid @entity1 in a @entity2 model. miRNAs highly expressed in the VX2 @entity1 may serve as novel candidates for molecular biomarkers and as potential drug targets.

title: Relevance of XXXX VX2 Tumor Model for Studies on @entity0 Hepatocellular Carcinoma: A MicroRNA-Based Study.

answer: @entity2


abstract: MicroRNAs are small (~22 nt), noncoding RNA molecules that have critical cellular functions in proliferation, differentiation, angiogenesis and apoptosis. miRNA expression profiling has been used to create signatures of @entity1 and, in many cases, it has been shown to correlate with the severity of the disease. The @entity2 VX2 @entity1 model has been used widely to study a number of @entity0 @entity1 . Our objective in this study is to generate an miRNA signature of the VX2 @entity1 and to identify miRNAs that are highly expressed in this @entity3 . In this study, we performed miRNA profiling of the @entity2 VX2 @entity1 using a microarray that has probes for 1292 unique miRNAs. Their expression in @entity1 samples was quantified and analyzed. We found that 35 miRNAs were significantly up-regulated in the VX2 @entity1 . Among these, 13 @entity0 miRNAs and eight members of the let-7 family were previously identified in @entity1 . In addition, we show that the expression of three miRNAs (miR-923, miR-1275, and miR-1308) is novel for the @entity2 VX2 @entity1 , and their expression was not previously shown to be associated with any type of @entity1 . For the first time, we show the miRNA signature profile for a solid @entity1 in a @entity2 model. miRNAs highly expressed in the VX2 @entity1 may serve as novel candidates for molecular biomarkers and as potential drug targets.

title: Relevance of @entity2 VX2 Tumor Model for Studies on XXXX Hepatocellular Carcinoma: A MicroRNA-Based Study.

answer: @entity0


abstract: BACKGROUND: Best practice models are calling for a holistic, needs-led, and sex-informed treatment approach to substance misuse treatment. To date, research into the impact of sex on needs and quality of life within @entity1 -treatment populations using validated research tools is limited. OBJECTIVES: The aim of the study was to evaluate the impact of sex upon self-rated unmet need and quality of life among @entity0 on @entity1 treatment. METHODS: Cross-sectional survey of adults attending a specialist @entity1 treatment clinic, in Dublin, Ireland. @entity0 completed the Camberwell Assessment of Need Short Appraisal Schedule, @entity0 Version and the WHO Quality of Life-Brief Version. Ongoing drug use was determined using the Maudsley Addiction Profile and weekly supervised urine toxicology screens. A linear regression analysis was conducted. RESULTS: One hundred eight of 190 eligible service-users (57%) participated. No significant differences existed between the @entity0 and the nonparticipants on demographic variables or measures of drug use. Among them, 33% were @entity0 . @entity0 demonstrated lower levels of ongoing opiate use. Linear regression analysis indicated that @entity0 had a greater number of unmet needs (P=0.02) and lower quality of life in the domains of physical health (P=0.003), psychological well being (P<0.001), environmental well being (P=0.03), and social relationships (P=0.007). When the Bonferroni adjustment was applied to account for multiple testing, the relationship between psychological well being and female sex remained statistically significant. CONCLUSIONS: Our study suggests that female sex may be associated with greater self-rated needs and poorer quality of life within a @entity1 -treated population, in particular, in the domain of psychological well being. Further research in this area is warranted to discover if these findings can be replicated and confirmed in larger samples.

title: The Impact of Sex Upon Needs and Quality of Life Within a Population on XXXX Treatment.

answer: @entity1


abstract: OBJECTIVE: To provide evidence for the existence of a wide range of molecules characteristic of fibrocartilage at normal alar ligament entheses, that may have a bearing on the pathogenesis of @entity1 . The alar ligaments provide the mechanical restraint for @entity3 and their integrity can be compromised in @entity0 with @entity1 and occasionally in those with @entity5 . METHODS: Both alar ligaments from 6 cadavers were fixed in 90% @entity4 and cryosectioned longitudinally. Sections were immunolabelled with antibodies against collagens, glycosaminoglycans, and proteoglycans. The immunohistochemical data were related to estimates of insertional angle change at the entheses that were calculated from measurements of ligament length and dens diameter. RESULTS: Molecules typical of fibrocartilage (including type II collagen, link protein, and aggrecan) were found at both entheses, but labelling was more prominent at the odontoid end. This correlated with a 3-fold greater insertional angle change during 40 degrees of @entity3 at the attachment of the ligament to the dens. At the odontoid enthesis, fibrocartilage differentiation was most conspicuous posteriorly. CONCLUSION: The changes in insertional angle mean that compressive forces are prominent at both entheses, but particularly at the odontoid end, where the ligament partly wraps around the dens during @entity3 . Thus, mechanical conditions are created that lead to pronounced fibrocartilage development, hence the expression of type II collagen, link protein, and aggrecan. The prominence of these molecules at the entheses raises the possibility that they could be antigenic targets for an autoimmune response in @entity2 .

title: Expression of a wide range of fibrocartilage molecules at the entheses of the alar ligaments - possible antigenic targets for XXXX ?

answer: @entity1


abstract: OBJECTIVE: To determine whether home-based neuromuscular electrical stimulation (NMES) applied to the @entity0 ( @entity0 ) muscle increases strength, physical activity, and physical performance in older adults with @entity3 ( @entity2 ). METHODS: Thirty-four adults (> 60 yrs) with radiographically confirmed symptomatic knee @entity2 were randomized to NMES plus education or education only (EDU). The primary outcome was isometric @entity0 peak torque (PTIso), with secondary outcomes of daily step counts, total activity vector magnitude, 100-foot walk-turn-walk, timed stair climb, chair rise, and @entity1 . The NMES group used a portable electrical muscle stimulator 3 days a week for unilateral @entity0 training with incremental increases in the intensity of isometric contraction to 30-40% of maximum over 12 weeks. Both groups received the 12-week Arthritis Self-Management course and were followed an additional 12 weeks. RESULTS: The stimulated knee-extensor showed a 9.1% increase in 120 degrees PTIso compared to a 7% loss in the EDU group (time x group interaction for 120 degrees PTIso; p = 0.04). The chair rise time decreased by 11% in the NMES group, whereas the EDU group saw a 7% reduction (p = 0.01, time; p = 0.9, group). Similarly, both groups improved their walk time by approximately 7% (p = 0.02, time; p = 0.61 group). Severity of @entity1 reported following intervention did not differ between groups. CONCLUSION: In older adults with knee @entity2 , a home-based NMES protocol appears to be a promising therapy for increasing @entity0 strength in adults with knee @entity2 without exacerbating @entity1 symptoms.

title: A home-based protocol of electrical muscle stimulation for quadriceps muscle strength in older adults with XXXX of the knee.

answer: @entity2


abstract: In recent years, it has become clear that self-nonself discrimination by the immune system is driven not so much by the specificities of the antigen receptors themselves, but by ligand-receptor systems that sense the presence of foreign pathogens (toll-like receptors) and those that regulate the balance between cellular proliferation and programmed cell @entity5 ( @entity1 necrosis factor [TNF] family ligands and receptors). Interestingly, these two receptor families share a number of common signaling pathways, mediated by the cytoplasmic proteins containing @entity5 domains and TRAF domains, which trigger the complementary processes of programmed cell @entity5 and @entity3 . Both @entity0 and @entity2 with @entity4 in the TNF-receptor family member Fas accumulate abnormal lymphocytes and develop systemic @entity6 . These findings highlighted the importance of this TNF-receptor family member in the homeostasis of the immune system. In particular, the Fas receptor has been shown to be important in immunoreceptor-mediated apoptosis of activated T and B lymphocytes. Six members of the TNF-receptor superfamily share a common signaling domain with Fas, termed the @entity5 domain, that directly links these receptors to the apoptotic machinery of the cell, and, collectively, these receptors have been designated as " @entity5 receptors."We are currently investigating a number of important unresolved issues in this field, including: (1). how susceptibility to apoptosis through @entity5 receptors is regulated, (2). how Fas and related @entity5 receptors function in the maintenance of self-tolerance and homeostasis in the major cell types of the immune system, and (3). recently described nonapoptotic lymphocyte activation signals that use components of @entity5 receptor signaling.

title: Death receptor signaling and XXXX .

answer: @entity6


abstract: OBJECTIVE: @entity2 is a prevalent idiopathic @entity1 with deleterious consequences for the sexuality of affected @entity0 and their spouses. Intimacy has been identified as a facilitator of adjustment to health difficulties in couples. Two components of intimacy were examined among couples with @entity2 -empathic response and disclosure-in relation to their sexual satisfaction and sexual distress. METHOD: Using an observational design, 50 @entity0 (Mage = 24.50 years, SD = 4.03) diagnosed with @entity2 and their spouses (Mage = 26.10 years, SD = 5.70) participated in a filmed discussion focusing on the impact of @entity2 on their lives. Empathic response and disclosure were assessed by a trained observer and self-reported by @entity0 after engaging in the discussion. The actor-partner interdependence model guided the data analyses. RESULTS: @entity0 's and spouses' higher observed and perceived empathic responses were associated with their own and their partners' greater sexual satisfaction. @entity0 's and spouses' higher perceived disclosures were associated with their own and their partners' greater sexual satisfaction. @entity0 's and spouses' higher observed empathic responses were associated with their own lower sexual distress. @entity0 's higher observed empathic responses were associated with their spouses' lower sexual distress. @entity0 and spouses' perceived greater empathic responses were associated with their own lower sexual distress. @entity0 's and spouses' greater perceived disclosures during the discussion were associated with their own and their partners' lower sexual distress. CONCLUSION: Promoting empathic response and disclosure through couple interventions may buffer against the sexual distress and sexual dissatisfaction of couples coping with @entity2 . (PsycINFO Database Record

title: Intimacy, Sexual Satisfaction, and Sexual Distress in XXXX Couples: An Observational Study.

answer: @entity2


abstract: Background. This study evaluated the impact of different doses of Astragalus polysaccharides (APS) on the functional status and phenotype of T cells during polymicrobial sepsis. Methods. On day 1 after cecal ligation and puncture, @entity1 were treated with either saline, 100 (A100), 200 (A200), or 400   mg APS/kg body weight (BW) (A400) by an intraperitoneal injection daily for 4 days. All @entity1 were sacrificed 5 days after the operation. Results. APS treatment reversed the sepsis-induced @entity5 helper (Th) cell population, and the percentage of activated Th cells also increased in the spleen and Peyer's patches. APS administration downregulated the percentages of circulating @entity2 cells and regulatory T cells (Treg), and the percentage of Th17 cells in blood was upregulated in the A400 group. @entity0 were attenuated in the A100 and A200 groups but not in the A400 group at the end of the study. Conclusions. Treatments with 100 and 200   mg APS/kg BW reduced Treg populations and elicited a more-balanced @entity4 / @entity2 response that consequently attenuated immunosuppression in polymicrobial sepsis. High-dose APS administration led to excessive responses of Th17 cells which may have adverse effects in sepsis-induced @entity3 .

title: Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in XXXX with Polymicrobial Sepsis.

answer: @entity1


abstract: The data on 80 cases of @entity2 are presented. The average age of @entity0 was 19.1. In 9 out of 18 menstruation--free @entity0 @entity5 was associated with @entity6 and intersexuality. @entity3 was the most frequent symptom (70%). In 82%, correct diagnosis was established during primary examination. Among the most frequent misdiagnoses were @entity4 or pregnancy. Stage I @entity1 was established in nearly 70%. Unilateral involvement was registered in 83.5% of cases. Metastatic spread was limited to peritoneal cavity in 19.2%, paraaortic lymph nodes were involved in 16.4%. Five-year survival rate was 71.4%. Such characteristics of @entity1 process as stage and size of @entity1 proved to be of the highest prognostic value. The choice of a treatment modality was found to produce an insignificant effect on the results of therapy.

title: [Clinical picture and treatment of XXXX @entity0 ].

answer: @entity2


abstract: The data on 80 cases of @entity2 are presented. The average age of @entity0 was 19.1. In 9 out of 18 menstruation--free @entity0 @entity5 was associated with @entity6 and intersexuality. @entity3 was the most frequent symptom (70%). In 82%, correct diagnosis was established during primary examination. Among the most frequent misdiagnoses were @entity4 or pregnancy. Stage I @entity1 was established in nearly 70%. Unilateral involvement was registered in 83.5% of cases. Metastatic spread was limited to peritoneal cavity in 19.2%, paraaortic lymph nodes were involved in 16.4%. Five-year survival rate was 71.4%. Such characteristics of @entity1 process as stage and size of @entity1 proved to be of the highest prognostic value. The choice of a treatment modality was found to produce an insignificant effect on the results of therapy.

title: [Clinical picture and treatment of @entity2 XXXX ].

answer: @entity0


abstract: Noncardiac @entity4 is a heterogeneous condition for which diagnosis and treatment are challenging. Research is needed to streamline evaluation to minimize unnecessary invasive testing and costs. @entity4 clinics to assess @entity4 @entity0 are popular in the United States and may be of value in reassuring @entity0 and reducing presentation to hospital; however, recently this has been contended [111]. Options for the effective treatment of NCCP are dependent on the risk of an adverse outcome and the cost-effectiveness of the management algorithm that is followed. Most (64%) of those presenting to the emergency department with @entity4 are classified as having NCCP [112,113]. @entity3 is probably the most important cause and application of a test of acid suppression with a high-dose PPI for 1 to 2 weeks seems to be a useful diagnostic tool. In those @entity0 with @entity3 -related NCCP, short-term and potentially long-term therapy with a PPI (commonly higher than standard dose) is required to alleviate symptoms. @entity6 is relatively uncommon in @entity0 with NCCP and evaluation by esophageal manometry might be limited to rule out @entity5 . @entity7 are common but probably often missed. Many @entity0 with NCCP have psychologic or @entity1 , as either the cause or an effect of the @entity4 , but diagnosis here depends on techniques not applied easily in the acute situation. @entity2 modulators seem to offer significant improvement in @entity4 for non- @entity3 -related NCCP. Finally, trials of management strategies to deal with this problem are required urgently, because the earlier discharge of @entity0 with NCCP may exacerbate the problem. Fig. 2 provides a flow chart for diagnosis and treatment of NCCP.

title: Noncardiac XXXX : evaluation and treatment.

answer: @entity4


abstract: Lower extremity @entity6 are a recognized complication of @entity4 ( @entity4 ). Their prevalence has not been assessed since the advent of more aggressive disease modifying antirheumatic therapies. The purpose of this study was to establish the period prevalence of lower extremity @entity6 in a modern-day unselected cohort of @entity0 with @entity4 , and to report the features associated with @entity6 development and response to therapy. Between June 2007 and June 2010, 366 @entity4 @entity0 were evaluated at the Georgetown Division of Rheumatology. Data were collected and analyzed retrospectively on demographics, antibody and prothrombotic profile, comorbidities, disease activity, and outcomes. The period prevalence of @entity6 in this cohort of 366 @entity0 with @entity4 followed over 3  years was 4.37%. @entity0 with @entity6 were predominantly female (81.25%) and more commonly African American (56.2%). The mean disease duration at @entity6 development was 25.9  years. All @entity0 with @entity6 had @entity3 and 63% were seropositive. Only five @entity0 (31.25%) healed over a mean follow-up of 22.8  months. However, in this small sample, treatment with anti- @entity1 @entity2 factor-a (anti- @entity5 ) therapy was associated with significantly higher likelihood of healing (p   =   0.039). In this modern-day cohort of @entity0 with @entity4 , we found a prevalence of lower extremity @entity6 of 4.37% over 3  years. Only 31.25% of @entity0 healed after a mean 22.8  months of follow-up. However, treatment with a biologic agent was associated with a significant increased likelihood of healing (RR 3.27, 95% CI 0.59-18.29, p   =   0.039).

title: Lower extremity XXXX in @entity4 : features and response to immunosuppression.

answer: @entity6


abstract: Lower extremity @entity6 are a recognized complication of @entity4 ( @entity4 ). Their prevalence has not been assessed since the advent of more aggressive disease modifying antirheumatic therapies. The purpose of this study was to establish the period prevalence of lower extremity @entity6 in a modern-day unselected cohort of @entity0 with @entity4 , and to report the features associated with @entity6 development and response to therapy. Between June 2007 and June 2010, 366 @entity4 @entity0 were evaluated at the Georgetown Division of Rheumatology. Data were collected and analyzed retrospectively on demographics, antibody and prothrombotic profile, comorbidities, disease activity, and outcomes. The period prevalence of @entity6 in this cohort of 366 @entity0 with @entity4 followed over 3  years was 4.37%. @entity0 with @entity6 were predominantly female (81.25%) and more commonly African American (56.2%). The mean disease duration at @entity6 development was 25.9  years. All @entity0 with @entity6 had @entity3 and 63% were seropositive. Only five @entity0 (31.25%) healed over a mean follow-up of 22.8  months. However, in this small sample, treatment with anti- @entity1 @entity2 factor-a (anti- @entity5 ) therapy was associated with significantly higher likelihood of healing (p   =   0.039). In this modern-day cohort of @entity0 with @entity4 , we found a prevalence of lower extremity @entity6 of 4.37% over 3  years. Only 31.25% of @entity0 healed after a mean 22.8  months of follow-up. However, treatment with a biologic agent was associated with a significant increased likelihood of healing (RR 3.27, 95% CI 0.59-18.29, p   =   0.039).

title: Lower extremity @entity6 in XXXX : features and response to immunosuppression.

answer: @entity4


abstract: The loss of the function in any one of four @entity0 DNA mismatch repair genes, @entity5 , @entity6 , @entity8 , and @entity7 , is thought to lead to deficient mismatch repair (MMR) of DNA in the somatic cells leading to increased mutations and thereby @entity1 development. @entity3 ( @entity3 ) detected by PCR analysis has, to date, been the hallmark of loss of the function of these genes. Western and Northern blotting has confirmed the loss of MMR protein expression with @entity3 . However, this technique relies on fresh samples for DNA extraction and requires a normal tissue sample (see Chapter 41). Expression of MMR proteins can now be examined in both fresh and archival paraffin-embedded tissue samples by immunohistochemistry. This was first described for polyclonal @entity5 antibody, in paraffin-embedded tissue, by Wilson et al. (1) and confirmed by Leach et al. (2), who showed that @entity5 is highly expressed in the nuclei cells of the gastrointestinal epithelium that undergo rapid renewal in both the ileum, colon, and esophagus. Thibodeau et al. (3) examined @entity4 -embedded tissue from @entity2 for both @entity6 and @entity5 genes and function by DNA sequence analysis, @entity3 analysis by PCR, and immunohistochemistry. They showed that loss of immunohistochemical staining for these MMR proteins corresponded very closely with loss of function of these genes detected by microsatellite analysis. Of 19 @entity1 showing @entity3 , 14 had loss of either or both @entity6 and @entity5 immunostaining. Of @entity1 showing a germline mutation in either @entity6 or @entity5 , seven had a corresponding loss of immunostaining for the protein. Of 14 @entity1 showing a negative immunostain for one or both of @entity6 and @entity5 , all had @entity3 on PCR analysis and seven had a germline mutation in the DNA sequence of at least one of the MMR genes. Fink et al. (4) have performed immunohistochemistry for @entity6 and @entity7 on fresh frozen tissue sections. They confirmed a high nuclear expression in the epithelium of the digestive tract and in the testis and ovary. We describe here a method for immunohistochemistry for @entity5 , @entity6 , and @entity7 in both fresh and paraffin-embedded material.

title: Immunostaining XXXX paraffin-embedded sections for mismatch repair proteins.

answer: @entity0


abstract: BACKGROUND: In this article, we aimed to discuss treatment strategies in @entity2 of the femoral head, which is a very rare injury. METHODS: We reviewed five @entity0 (six @entity2 ) who admitted to our emergency department due to femoral @entity2 between March 2006 and December 2007. Functional outcomes of the @entity0 who were treated operatively and nonoperatively were compared. RESULTS: Half of the @entity2 were treated nonoperatively and half of them surgically. We observed a rate of 50% excellent to good results. @entity4 developed in a @entity0 with @entity1 . The functional results were poor for this @entity0 . Early posttraumatic @entity3 was observed in a @entity0 who was treated surgically; this @entity0 had moderate results. CONCLUSION: We should aim at anatomic reduction of the fragments with minimum soft tissue injury. The best approach should be chosen for excellent view of the fragments. We should not forget that half of these @entity0 will have a poor outcome despite all treatment strategies.

title: XXXX of the femoral head: what are the reasons for poor outcome?

answer: @entity2


abstract: OBJECTIVE: To investigate the influence of artificial liver support system on severe @entity4 with @entity0 , 37 cases of severe @entity4 and 80 cases times of plasma replacement were analyzed. METHODS: The volume of plasma replacement was 2,000-2,600 ml/time. Japanese Plasauto-iQ Blood Purifying Device was used. Blood samples were observed before and after plasma replacement to determine liver function and prothrombin time. PBMCs were isolated and cultured, and the supernatants were collected to determine the levels of @entity3 ( @entity3 ), IL-12 and gamma-interferon (gamma-IFN). RESULTS: Before plasma replacement, 32 cases of 80 case times had @entity0 , 5 cases of them had fever, the temperature was 37.5-38.0 centigrade. Four cases of them were @entity2 , 1 case was @entity1 . After plasma replacement, liver function was improved, temperature was normal @entity0 was controlled. The levels of @entity3 , IL-12 and gamma-IFN in supernatants before and after plasma replacement were significantly higher than normal control, and the @entity3 level after plasma replacement was markedly higher than that before plasma replacement. The levels of IL-12 and gamma-IFN after plasma replacement were higher than plasma replacement, but they didn't reached statistic difference. CONCLUSION: Plasma replacement might be helpful to control @entity0 and therefore to stabilized the @entity4 .

title: [Influence of plasma replacement on the @entity4 with XXXX ].

answer: @entity0


abstract: OBJECTIVE: To investigate the influence of artificial liver support system on severe @entity4 with @entity0 , 37 cases of severe @entity4 and 80 cases times of plasma replacement were analyzed. METHODS: The volume of plasma replacement was 2,000-2,600 ml/time. Japanese Plasauto-iQ Blood Purifying Device was used. Blood samples were observed before and after plasma replacement to determine liver function and prothrombin time. PBMCs were isolated and cultured, and the supernatants were collected to determine the levels of @entity3 ( @entity3 ), IL-12 and gamma-interferon (gamma-IFN). RESULTS: Before plasma replacement, 32 cases of 80 case times had @entity0 , 5 cases of them had fever, the temperature was 37.5-38.0 centigrade. Four cases of them were @entity2 , 1 case was @entity1 . After plasma replacement, liver function was improved, temperature was normal @entity0 was controlled. The levels of @entity3 , IL-12 and gamma-IFN in supernatants before and after plasma replacement were significantly higher than normal control, and the @entity3 level after plasma replacement was markedly higher than that before plasma replacement. The levels of IL-12 and gamma-IFN after plasma replacement were higher than plasma replacement, but they didn't reached statistic difference. CONCLUSION: Plasma replacement might be helpful to control @entity0 and therefore to stabilized the @entity4 .

title: [Influence of plasma replacement on the XXXX with @entity0 ].

answer: @entity4


abstract: OBJECTIVES: The objective of this study was to retrospectively analyze the incidence of the concurrent existence of @entity4 ( @entity4 ) and @entity1 . METHODS: Forty @entity0 (36 female, 4 male, mean age: 29.9  9.6 years) clinically diagnosed with @entity4 were screened. @entity0 records were analyzed regarding: range of mouth opening, @entity3 ( @entity3 ) noises, @entity2 on palpation of the @entity3 and masticatory muscles and neck and upper back muscles, and magnetic resonance imaging of the @entity3 . RESULTS: According to @entity0 records, a total of 40 (66.6%) @entity0 were diagnosed with @entity4 among 60 @entity0 with @entity1 . Thirty-two (53%) @entity0 had @entity3 internal derangement (ID), 8 (13%) @entity0 had only @entity2 ( @entity2 ) and 25 (41.6%) @entity0 had concurrent @entity3 ID/ @entity2 . There were statistically significant relationships between the number of tender masseter muscles and @entity2 @entity0 (p=0.04) and between the number of tender medial pterygoid muscles and @entity0 with reducing disc displacement (RDD) (p=0.03). CONCLUSION: The @entity3 and associated orofacial structures should be considered as possible triggering or perpetuating factors for @entity1 , especially tension-type. There might be a significant connection between @entity4 and @entity1 . However, most medical and dental practitioners are unaware of this relationship. Therefore, a careful evaluation of the @entity3 and associated orofacial structures is required for a correct interpretation of the @entity5 in @entity1 @entity0 , and these @entity0 should be managed with a multidisciplinary approach.

title: The relationship of @entity4 with XXXX : a retrospective analysis.

answer: @entity1


abstract: OBJECTIVES: The objective of this study was to retrospectively analyze the incidence of the concurrent existence of @entity4 ( @entity4 ) and @entity1 . METHODS: Forty @entity0 (36 female, 4 male, mean age: 29.9  9.6 years) clinically diagnosed with @entity4 were screened. @entity0 records were analyzed regarding: range of mouth opening, @entity3 ( @entity3 ) noises, @entity2 on palpation of the @entity3 and masticatory muscles and neck and upper back muscles, and magnetic resonance imaging of the @entity3 . RESULTS: According to @entity0 records, a total of 40 (66.6%) @entity0 were diagnosed with @entity4 among 60 @entity0 with @entity1 . Thirty-two (53%) @entity0 had @entity3 internal derangement (ID), 8 (13%) @entity0 had only @entity2 ( @entity2 ) and 25 (41.6%) @entity0 had concurrent @entity3 ID/ @entity2 . There were statistically significant relationships between the number of tender masseter muscles and @entity2 @entity0 (p=0.04) and between the number of tender medial pterygoid muscles and @entity0 with reducing disc displacement (RDD) (p=0.03). CONCLUSION: The @entity3 and associated orofacial structures should be considered as possible triggering or perpetuating factors for @entity1 , especially tension-type. There might be a significant connection between @entity4 and @entity1 . However, most medical and dental practitioners are unaware of this relationship. Therefore, a careful evaluation of the @entity3 and associated orofacial structures is required for a correct interpretation of the @entity5 in @entity1 @entity0 , and these @entity0 should be managed with a multidisciplinary approach.

title: The relationship of XXXX with @entity1 : a retrospective analysis.

answer: @entity4


abstract: INTRODUCTION: @entity5 ( @entity5 ) is an @entity2 that starts in childhood and has an unknown pathophysiological mechanism. Studies on the progress of @entity5 reveal a poor prognosis. @entity0 AND METHODS: A retrospective study of 1629 @entity0 with @entity2 was conducted. @entity0 included in the study were those with an age of onset during childhood, tonic @entity3 and atypical absences (who might also suffer from other types of @entity3 ); electroencephalogram (EEG) showing generalised slow spike-wave and generalised fast activity; @entity4 and a follow-up time of at least 10 years. RESULTS: The sample consisted of 12 @entity0 , 9 of whom were males. Follow-up time: 20 years. Onset of @entity3 : 3 years. Cryptogenic @entity5 : 67%; symptomatic: 33%. Frequency of the @entity3 at onset: daily (83.3%) or weekly (16.7%). Types of @entity3 : tonic and atypical absences (100%); drop-attacks (83%); generalised tonic-clonic (75%); myoclonias (41.7%); partial (8.3%) and pseudo- @entity2 (8.3%). EEG with slow background activity, generalised slow spike-wave and generalised fast activity: 100%. Fifty percent of the @entity0 had at least one @entity2 status. They used an average of 7.5 different antiepileptic drugs. At the end of the follow-up 33% were suffering from @entity3 on a daily basis; 17% were weekly and 42% monthly. A total of 8.3% were free from @entity3 . All of them were following combination therapy: 17% in bitherapy and 83% with an average of 3.8 drugs (range: 3-5). A total of 92% suffered from severe or very severe @entity4 . Fifty percent required neuroleptic drugs due to @entity1 . CONCLUSIONS: Despite the fact that the diagnosis of @entity5 is serious, we observed a decrease in the number of @entity3 after several years of development, although the antiepileptic combination therapy remains constant. The @entity4 and @entity1 lead to a poor functional prognosis.

title: [Development of XXXX in adulthood].

answer: @entity5


abstract: To evaluate all inconclusive @entity2 ( @entity2 ) specimens from @entity4 with subsequent histologic diagnosis at St John Hospital and Medical Center, Detroit, MI. The criterion for specimen adequacy used in our institution was also reexamined to determine whether it was too stringent. We reviewed 45 inconclusive @entity2 samples. Only cases that underwent surgical intervention were considered. Specimen adequacy was determined by the presence of at least 8-10 tissue fragments of well-preserved follicular epithelium on at least two slides; each tissue fragment should have a minimum of 8-10 cells. Different cytologic characteristics-cellularity, cellular architecture, nuclear pleomorphism, inclusion/grooves, chromatin, H  rthle cell change, lymphocytes, macrophages, colloid, and multinucleated giant cells-were scored and compared with final surgical diagnosis. The surgical procedure performed was also analyzed. Review of these 45 surgical specimens found 28 (62.2%) multinodular @entity6 , 14 (31.1%) @entity5 , 2 (4.4%) @entity3 , and one (2.2%) with invasive @entity1 . Forty-three (95.6%) of these cases were female and 2 (4.4%) were male. Cytologic review showed 2 acellular samples, 10 cases containing macrophages only, 10 aspirates with macrophages and an inadequate number of follicular cells, and 23 specimens with an inadequate number of follicular cells. Twenty-three @entity0 underwent total thyroidectomy; 20, lobectomy; and 2, isthumusectomy. Almost 98% of the @entity0 with inconclusive @entity2 had benign lesions. This finding encouraged us to continue using our criteria for adequacy because of the importance of a negative report. @entity0 in our series, who underwent thyroidectomy after an inconclusive or nondiagnostic aspirate, had a malignancy rate of 2.2%, which was no worse than @entity0 with a benign preoperative diagnosis. A balanced approach with careful follow-up for nondiagnostic cytology is prudent.

title: Analysis of inconclusive fine-needle aspiration of XXXX .

answer: @entity4


abstract: BACKGROUND: @entity2 is the most common non-cutaneous @entity1 in @entity0 . Radical prostatectomy (RP) is a mainstay of treatment for organ-confined @entity2 . Preoperatively, the process of planning RP is based on local stage and precisely defines the location and size of disease within the prostate. Nowadays, there is no technology that can accurately map @entity2 within the gland. Hence, urologists rely mainly on information provided by histopathological examination of biopsy cores, but this information does not accurately locate or @entity1 . The purpose of this study was to provide the surgeon with a 3D visualization tool capable of showing the location and extent of @entity1 within the prostate. METHODS: To perform this task, an application named iProstate, which makes use of four different mathematical predictive models that use biopsy cores information, was developed. These predictive models were trained with 277 clinical reports from @entity0 who had undergone radical prostatectomy. Two sets of data from the @entity0 reports were used to train the predictive models, the first containing the lengths of the biopsy cores and the @entity1 percentages of the biopsy cores information, and the second containing the lengths of the biopsy cores, @entity1 percentages of the biopsy cores, Gleason score, PSA and gland volume information. RESULTS: Multilayer Perceptron was the predictive model that scored the better results, giving a better approximation in the prediction of location and extent of @entity1 in the prostatic gland. Gleason score, PSA and gland volume proved to be important variables for the training of the predictive model. CONCLUSIONS: The application was able to perform predictions of the location and extent of @entity1 that were very close to the real location and extent of @entity1 observed in the whole mount radical prostatectomy specimens, therefore its implementation in clinical assessment and follow-up should be considered.

title: iProstate, a mathematical predictive model-based, 3D-rendering tool to visualize the location and extent of XXXX .

answer: @entity2


abstract: OBJECTIVE: Many authors have demonstrated that @entity1 ( @entity1 ) and their related risk factors can predict @entity3 ( @entity3 ). The penile Doppler ultrasonography is a method to evaluate the cavernous blood flow in @entity0 with suspected @entity8 . The goal of our study was to evaluate if @entity3 is associated to a @entity5 and which is the role of penile Doppler investigation. MATERIAL AND METHODS: 90 @entity0 (group 1) complaining @entity3 , but no symptoms of @entity1 were prospectively evaluated with penile Doppler ultrasound. The controls (group 2) were 45 apparently healthy subjects. Both groups were submitted to carotid and aortal-iliac Doppler ultrasonography. RESULTS: 50 @entity0 (mean age 60.5 +/- 4.6 years) in group 1 (IIEF < 15) and 45 subjects (mean age 59.5 +/- 4.6 years) in group 2 (IIEF > 15) were recruited. Mean age, height, LDL- @entity2 and blood pressure value were not statistically different (p = 0.417) between the two groups. Statistically significant differences were found in weight values (p = 0.016). Only 8 @entity0 (4%) were affected by @entity7 and 42.1% by veno-occlusive mechanism insufficiency (p > 0.05). The cavernosal artery diameters were within 0.7 +/- 0.2 and 1.2 +/- 0.1 mm. All @entity0 with a diagnosis of @entity8 of either arterial or venous origin were found asymptomatically affected by both a diffuse thickenings > 1 mm or a non hemodynamic plaque in the other vessels examined (carotid arteries or aorta or iliac arteries). DISCUSSION: Looking at our results, @entity3 is associated to diffuse thickness > 1 mm or with a non hemodynamic plaque of @entity6 origin in other vessels. These data confirm the theory that impotence has to be considered as a risk marker for @entity1 ( @entity1 ) in @entity0 with no cardiovascular symptoms. In our opinion, the penile echo Doppler is not able to show any @entity4 in terms of loss of mediator releasing. CONCLUSION: In case of suspect @entity8 , even if penile Doppler is not pathological, it would be worth performing a systemic Doppler evaluation of main arteries in order to investigate the presence of @entity6 finding and institute a preventive therapy for @entity1 .

title: The role of Doppler ultrasound in the diagnosis of XXXX .

answer: @entity8


abstract: BACKGROUND: @entity2 is an uncommon @entity1 that is thought to be the malignant counterpart of the trichilemmoma. Despite histologic features such as pronounced cytologic atypia, @entity2 is often described as having a rather benign clinical course. Cases of @entity1 recurrence after therapy are uncommon, and @entity1 neurotropism has never been described. OBJECTIVE: A case of multiply recurrent @entity2 with @entity0 is described. The outer root sheath differentiation of this @entity1 is confirmed with the use of novel antibodies directed toward cytokeratins that are expressed in this area of the hair follicle. METHODS: The @entity2 was excised using the Mohs surgical technique. Tissue obtained during the extirpation of the @entity1 was subjected to immunohistochemical staining for @entity4 , @entity5 , and @entity3 . RESULTS: Tumor neurotropism was noted. The @entity2 demonstrated abundant cytoplasmic staining for @entity5 and @entity3 . CONCLUSIONS: In distinction to previous reports, this case reveals that @entity2 can demonstrate significant biological aggression, as reflected by @entity1 neurotropism and by failure to respond to multiple surgical excisions. The purported outer root sheath differentiation of this @entity1 is confirmed with the use of novel immunohistochemical staining. This immunohistochemical staining may be useful in differentiating @entity2 from other clear cell neoplasms.

title: Multiply recurrent @entity2 with @entity0 and XXXX positivity.

answer: @entity5


abstract: BACKGROUND: @entity2 is an uncommon @entity1 that is thought to be the malignant counterpart of the trichilemmoma. Despite histologic features such as pronounced cytologic atypia, @entity2 is often described as having a rather benign clinical course. Cases of @entity1 recurrence after therapy are uncommon, and @entity1 neurotropism has never been described. OBJECTIVE: A case of multiply recurrent @entity2 with @entity0 is described. The outer root sheath differentiation of this @entity1 is confirmed with the use of novel antibodies directed toward cytokeratins that are expressed in this area of the hair follicle. METHODS: The @entity2 was excised using the Mohs surgical technique. Tissue obtained during the extirpation of the @entity1 was subjected to immunohistochemical staining for @entity4 , @entity5 , and @entity3 . RESULTS: Tumor neurotropism was noted. The @entity2 demonstrated abundant cytoplasmic staining for @entity5 and @entity3 . CONCLUSIONS: In distinction to previous reports, this case reveals that @entity2 can demonstrate significant biological aggression, as reflected by @entity1 neurotropism and by failure to respond to multiple surgical excisions. The purported outer root sheath differentiation of this @entity1 is confirmed with the use of novel immunohistochemical staining. This immunohistochemical staining may be useful in differentiating @entity2 from other clear cell neoplasms.

title: Multiply recurrent XXXX with @entity0 and @entity5 positivity.

answer: @entity2


abstract: BACKGROUND: @entity2 is an uncommon @entity1 that is thought to be the malignant counterpart of the trichilemmoma. Despite histologic features such as pronounced cytologic atypia, @entity2 is often described as having a rather benign clinical course. Cases of @entity1 recurrence after therapy are uncommon, and @entity1 neurotropism has never been described. OBJECTIVE: A case of multiply recurrent @entity2 with @entity0 is described. The outer root sheath differentiation of this @entity1 is confirmed with the use of novel antibodies directed toward cytokeratins that are expressed in this area of the hair follicle. METHODS: The @entity2 was excised using the Mohs surgical technique. Tissue obtained during the extirpation of the @entity1 was subjected to immunohistochemical staining for @entity4 , @entity5 , and @entity3 . RESULTS: Tumor neurotropism was noted. The @entity2 demonstrated abundant cytoplasmic staining for @entity5 and @entity3 . CONCLUSIONS: In distinction to previous reports, this case reveals that @entity2 can demonstrate significant biological aggression, as reflected by @entity1 neurotropism and by failure to respond to multiple surgical excisions. The purported outer root sheath differentiation of this @entity1 is confirmed with the use of novel immunohistochemical staining. This immunohistochemical staining may be useful in differentiating @entity2 from other clear cell neoplasms.

title: Multiply recurrent @entity2 with XXXX and @entity5 positivity.

answer: @entity0


abstract: To evaluate the influence of diet on faecal DNA amplification, 11 captive @entity3 ( @entity3 ) were placed on six restricted diets: grass (Trifolium spp., Haplopappus hirtus and Poa pratensis), alfalfa (Lupinus spp.), @entity2 (Daucus spp.), @entity1 ( @entity1 ), blueberries (Vaccinium spp.) and salmon (Salmo spp.). DNA was extracted from 50 faecal samples of each restricted diet, and amplification of @entity3 DNA was attempted for a mitochondrial DNA (mtDNA) locus and nuclear DNA (nDNA) locus. For mtDNA, no significant differences were observed in amplification success rates across diets. For nDNA, amplification success rates for salmon diet extracts were significantly lower than all other diet extracts (P < 0.001). To evaluate the accuracy of faecal DNA sex identification when female carnivores consume male @entity0 prey, female bears were fed male @entity1 . Four of 10 extracts amplified, and all extracts were incorrectly scored as male due to amplification of X and Y-chromosome fragments. The potential biases highlighted in this study have broad implications for researchers using faecal DNA for individual and sex identification, and should be evaluated in other species.

title: The influence of diet on faecal DNA amplification and sex identification in XXXX ( @entity3 ).

answer: @entity3


abstract: To evaluate the influence of diet on faecal DNA amplification, 11 captive @entity3 ( @entity3 ) were placed on six restricted diets: grass (Trifolium spp., Haplopappus hirtus and Poa pratensis), alfalfa (Lupinus spp.), @entity2 (Daucus spp.), @entity1 ( @entity1 ), blueberries (Vaccinium spp.) and salmon (Salmo spp.). DNA was extracted from 50 faecal samples of each restricted diet, and amplification of @entity3 DNA was attempted for a mitochondrial DNA (mtDNA) locus and nuclear DNA (nDNA) locus. For mtDNA, no significant differences were observed in amplification success rates across diets. For nDNA, amplification success rates for salmon diet extracts were significantly lower than all other diet extracts (P < 0.001). To evaluate the accuracy of faecal DNA sex identification when female carnivores consume male @entity0 prey, female bears were fed male @entity1 . Four of 10 extracts amplified, and all extracts were incorrectly scored as male due to amplification of X and Y-chromosome fragments. The potential biases highlighted in this study have broad implications for researchers using faecal DNA for individual and sex identification, and should be evaluated in other species.

title: The influence of diet on faecal DNA amplification and sex identification in @entity3 ( XXXX ).

answer: @entity3


abstract: OBJECTIVE: To identify the @entity2 to drive after @entity1 , following a systematic review and meta-analysis. METHODS: Twenty databases were searched, from inception until @entity3 , 2010. Potentially relevant studies were reviewed by 2 authors for eligibility. Methodologic quality was assessed by Newcastle-Ottawa scores. The @entity2 -to-drive outcome was a pass-fail decision following an on-road evaluation. Differences in off-road performance between the pass and fail groups were calculated using weighted mean effect sizes (d(w)). Statistical heterogeneity was determined with the I   statistic. Random-effects models were performed when the assumption of homogeneity was not met. Cutoff scores of accurate determinants were estimated via receiver operating characteristic analyses. RESULTS: Thirty studies were included in the systematic review and 27 in the meta-analysis. Out of 1,728 @entity0 , 938 (54%) passed the on-road evaluation. The best determinants were Road Sign Recognition (d(w) 1.22; 95% confidence interval [CI] 1.01-1.44; I(2), 58%), Compass (d(w) 1.06; 95% CI 0.74-1.39; I  , 36%), and Trail Making Test B (TMT B; d(w) 0.81; 95% CI 0.48-1.15; I(2), 49%). Cutoff values of 8.5 points for Road Sign Recognition, 25 points for Compass, and 90 seconds for TMT B were identified to classify unsafe drivers with accuracies of 84%, 85%, and 80%, respectively. Three out of 4 studies found no increased risk of accident involvement in @entity0 cleared to resume driving after @entity1 . CONCLUSIONS: The Road Sign Recognition, Compass, and TMT B are clinically administrable office-based tests that can be used to identify @entity0 with @entity1 at risk of failing an on-road assessment.

title: Screening for XXXX to drive after @entity1 : a systematic review and meta-analysis.

answer: @entity2


abstract: OBJECTIVE: To identify the @entity2 to drive after @entity1 , following a systematic review and meta-analysis. METHODS: Twenty databases were searched, from inception until @entity3 , 2010. Potentially relevant studies were reviewed by 2 authors for eligibility. Methodologic quality was assessed by Newcastle-Ottawa scores. The @entity2 -to-drive outcome was a pass-fail decision following an on-road evaluation. Differences in off-road performance between the pass and fail groups were calculated using weighted mean effect sizes (d(w)). Statistical heterogeneity was determined with the I   statistic. Random-effects models were performed when the assumption of homogeneity was not met. Cutoff scores of accurate determinants were estimated via receiver operating characteristic analyses. RESULTS: Thirty studies were included in the systematic review and 27 in the meta-analysis. Out of 1,728 @entity0 , 938 (54%) passed the on-road evaluation. The best determinants were Road Sign Recognition (d(w) 1.22; 95% confidence interval [CI] 1.01-1.44; I(2), 58%), Compass (d(w) 1.06; 95% CI 0.74-1.39; I  , 36%), and Trail Making Test B (TMT B; d(w) 0.81; 95% CI 0.48-1.15; I(2), 49%). Cutoff values of 8.5 points for Road Sign Recognition, 25 points for Compass, and 90 seconds for TMT B were identified to classify unsafe drivers with accuracies of 84%, 85%, and 80%, respectively. Three out of 4 studies found no increased risk of accident involvement in @entity0 cleared to resume driving after @entity1 . CONCLUSIONS: The Road Sign Recognition, Compass, and TMT B are clinically administrable office-based tests that can be used to identify @entity0 with @entity1 at risk of failing an on-road assessment.

title: Screening for @entity2 to drive after XXXX : a systematic review and meta-analysis.

answer: @entity1


abstract: BACKGROUND: Thyroid antibodies (Thy-Abs) are frequently detected in various @entity4 in coexistence with other systemic autoantibodies. In association with an @entity2 , they are often taken as evidence of @entity8 ( @entity8 ). However, the presence of Thy-Abs in a cohort of @entity7 ( @entity7 ) @entity0 and their association with anti-neuronal autoimmunity has not been explored. @entity0 AND METHODS: We investigated thyroid and anti-neuronal antibodies in the sera of 24 @entity7 @entity0 without identified @entity1 by cell-based assay and radioimmunoassay and evaluated their clinical features. RESULTS: There was a female predominance in Thy-Ab-positive @entity7 @entity0 . Five of the eight Thy-Ab-positive @entity0 and six of the 16 Thy-Ab-negative patients had antibodies to voltage-gated @entity5 channel (VGKC), @entity6 receptor (NMDAR) or undefined surface antigens on cultured hippocampal neurons. There were trends towards fewer VGKC antibodies (1/8 vs. 5/16, P = 0.159) and more NMDAR antibodies (2/8 vs. 1/16, P = 0.095) among the Thy-Ab-positive @entity7 patients; antibodies to undefined surface antigens were only identified in Thy-Ab-positive @entity0 (2/8 vs. 0/16, P = 0.018). There were no distinguishing clinical features between Thy-Ab-positive @entity0 with and without neuronal antibodies. However, patients with anti-neuronal antibodies showed a better treatment response. CONCLUSION: Thy-Abs can be found in a high proportion of @entity0 with non-paraneoplastic @entity7 , often in association with antibodies to specific or as yet undefined neuronal surface antigens. These results suggest that acute idiopathic @entity3 @entity0 with Thy-Abs should be closely monitored for ion-channel antibodies and it should not be assumed that they have @entity8 .

title: Autoantibodies to neuronal surface antigens in thyroid antibody-positive and -negative XXXX .

answer: @entity7


abstract: BACKGROUND: Mohs micrographic surgery (MMS) is based on microscopically controlled excision of cutaneous @entity1 and offers the highest cure rates with maximum tissue preservation. In vivo confocal microscopy (CM) allows noninvasive optical imaging of thin sections of living skin, in its native state, in real time, with high resolution and contrast. OBJECTIVE: To evaluate the feasibility of the use of in vivo CM as a surgical guide in MMS. METHODS: Five @entity0 with a biopsy-proven @entity3 ( @entity3 ) were imaged by in vivo CM on one or two sites from the clinically visible @entity2 . The first Mohs layer was then excised, and the fresh-frozen sections were correlated with the CM findings. @entity6 ( @entity7 ) 20% was applied on the Mohs defect followed by in vivo CM on one site from each lesion. A second Mohs layer was subsequently excised, and fresh-frozen sections were correlated with CM findings. RESULTS: The findings of in vivo CM were confirmed by @entity4 and @entity5 -stained frozen sections after excisions of the first and second Mohs layers. @entity7 was found to provide an excellent contrast between @entity3 cells and the surrounding tissue, detected readily with both in vivo and ex vivo CM. The @entity1 cells with @entity7 exhibited intensely bright nuclei with an excellent contrast as compared with the low-contrast dark nuclei without @entity7 application. CONCLUSION: In vivo CM is a potential surgical guide for MMS, and @entity7 provides an excellent exogenous agent to enhance @entity1 contrast for CM.

title: In vivo real-time confocal reflectance microscopy: a noninvasive guide for Mohs micrographic surgery facilitated by XXXX , an excellent contrast enhancer.

answer: @entity6


abstract: 1. @entity1 and opiate narcotics are potent analgesics that have a high propensity to induce tolerance and physical @entity0 following their repeated administration. 2. The molecular basis of @entity2 has not been completely elucidated, although the participation of opioid receptors is a prerequisite. Cellular @entity0 on opioids is believed to result from the chronic stimulation of opioid-regulated signalling networks. 3. As G-protein-coupled receptors, the opioid receptors must rely on heterotrimeric G-proteins for signal transduction. Recent advances in our understanding of G-protein signalling have unveiled novel signalling molecules and mechanisms, some of which may be intricately involved in the manifestation of @entity2 . 4. In the present review, we will attempt to trace chronic opioid signals along elaborate G-protein-regulated pathways.

title: Molecular basis of XXXX : role of signal regulation by G-proteins.

answer: @entity2


abstract: OBJECTIVE: To describe the clinical expression of @entity2 ( @entity2 ) in @entity0 , their use of exogenous sex hormones, and the effects on @entity2 . DESIGN: A retrospective population-based study. SUBJECTS: All @entity0 aged > or =18 years (n = 190) with DNA-diagnosed @entity2 in northern Sweden. RESULTS: A total of 166 @entity0 (87%) participated; 91 (55%) had @entity2 . Severe attacks were reported by 82%; 39% reported recurrent @entity2 attacks and 22% reported chronic @entity2 . Oral hormonal contraceptives had been used by 58% of all these @entity0 and by 50 with @entity2 (57%). Twelve @entity0 (24%) associated oral contraceptives as precipitating @entity2 attacks; in nine cases their first attack. One @entity0 experienced relief from @entity2 . On commencing their treatment, 72% of the @entity0 with @entity2 had not yet suffered their first attack. Twenty-two @entity0 (25%) aged > or =45 years had used hormonal replacement therapy (HRT) at menopause to remedy climacteric symptoms (the percutaneous route was most frequently used); no @entity2 attack was precipitated. HRT to remedy vaginal dryness was used by 26 @entity0 (28%) aged > or =45 years without triggering an @entity2 attack. Miscarriages were more frequent in @entity0 with @entity2 (50%) than in the latent group (30%, P = 0.014). CONCLUSIONS: About half of the @entity0 with @entity2 had used oral hormonal contraceptives. As 25% of @entity0 with @entity2 reported attacks associated with such drugs, caution must still be recommended. Menopausal HRT only rarely affected the disorder. @entity1 was more common amongst @entity0 with @entity2 .

title: Acute intermittent porphyria in XXXX : clinical expression, use and experience of exogenous sex hormones. A population-based study in northern Sweden.

answer: @entity0


abstract: UNASSIGNED: @entity7 ( @entity7 ) is the life-threatenig sequela of @entity3 by Shiga toxin (Stx)-producing @entity4 (STEC) in @entity0 . @entity0 neutrophils specifically bind Stx through @entity8 , the receptor of @entity5 . The binding could be considered protective (Stx sequestration) or harmful (toxin delivery to target organs). The amount of Stx on neutrophils is in equilibrium with the amount of Stx present in the gut, and it is also related to @entity1 . The @entity8 -mediated interaction of @entity5 with innate immune cells is hampered by the well-known antibiotic @entity10 . In this study, we show that the same antibiotic impairs the binding of Stx to neutrophils, also blocking their functional effects (release of @entity6 , formation of neutrophil/platelet aggregates) involved in @entity7 pathogenesis. Controls for contaminating @entity5 in Stx-induced neutrophil responses inhibited by @entity10 were performed. Stx interact with @entity0 neutrophils through their A chain, since these leukocytes do not express globotriaosylceramide, the specific receptor for Stx B chains. Consistently, @entity10 blocked the enzymatic activity of @entity11 , @entity12 , @entity11 chain, and the analogous plant protein gelonin, whereas the antibiotic did not show any protective effect on Stx-induced @entity2 in globotriaosylceramide-expressing Raji cells. Antibiotic administration is not recommended in @entity0 STEC infections during the prodromal intestinal phase, and the @entity2 of @entity10 could further discourage its therapeutic use. However, nontoxic, nonbactericidal @entity9 derivatives have been developed and might be used in animal models of @entity3 to study their efficacy in preventing the onset of @entity7 during the systemic blood phase of Stx.

title: The Antibiotic XXXX Impairs the Interactions between Shiga Toxins and @entity0 Neutrophils.

answer: @entity10


abstract: UNASSIGNED: @entity7 ( @entity7 ) is the life-threatenig sequela of @entity3 by Shiga toxin (Stx)-producing @entity4 (STEC) in @entity0 . @entity0 neutrophils specifically bind Stx through @entity8 , the receptor of @entity5 . The binding could be considered protective (Stx sequestration) or harmful (toxin delivery to target organs). The amount of Stx on neutrophils is in equilibrium with the amount of Stx present in the gut, and it is also related to @entity1 . The @entity8 -mediated interaction of @entity5 with innate immune cells is hampered by the well-known antibiotic @entity10 . In this study, we show that the same antibiotic impairs the binding of Stx to neutrophils, also blocking their functional effects (release of @entity6 , formation of neutrophil/platelet aggregates) involved in @entity7 pathogenesis. Controls for contaminating @entity5 in Stx-induced neutrophil responses inhibited by @entity10 were performed. Stx interact with @entity0 neutrophils through their A chain, since these leukocytes do not express globotriaosylceramide, the specific receptor for Stx B chains. Consistently, @entity10 blocked the enzymatic activity of @entity11 , @entity12 , @entity11 chain, and the analogous plant protein gelonin, whereas the antibiotic did not show any protective effect on Stx-induced @entity2 in globotriaosylceramide-expressing Raji cells. Antibiotic administration is not recommended in @entity0 STEC infections during the prodromal intestinal phase, and the @entity2 of @entity10 could further discourage its therapeutic use. However, nontoxic, nonbactericidal @entity9 derivatives have been developed and might be used in animal models of @entity3 to study their efficacy in preventing the onset of @entity7 during the systemic blood phase of Stx.

title: The Antibiotic @entity10 Impairs the Interactions between Shiga Toxins and XXXX Neutrophils.

answer: @entity0


abstract: OBJECTIVES: To translate and culturally adapt the Shoulder @entity1 and Disability Index (SPADI) into Brazilian-Portuguese and to assess its reliability. METHODS: The first step was the translation, synthesis, back-translation, revision by the committee, pre-testing and evaluation of documents by the committee and the author of the SPADI. The revised version by the committee was applied to 90 subjects with @entity2 , aged over 18 years from different education and sociocultural levels. The items misunderstood by 20% or more of @entity0 were reformulated and reapplied until they reach values lower than 20%. The second stage consisted of two applications of SPADI to 32 @entity0 with @entity2 in a interval ranging from 2 to 7 days. The data from the translation were analyzed descriptively, the test-retest reliability by Intraclass Correlation Coefficient (ICC) and the internal consistency by Cronbach's Alpha. RESULTS: Some expressions have been adapted to the Brazilian population and the items in the @entity1 and disability subscales were changed for an easier reading in Portuguese Language. The pre-test revealed a need to change only one item of the @entity1 domain and to administer the questionnaire by interview, since it was repeated three times and in the first two applications with self-reported questionnaire the @entity0 had not been reporting their symptoms with regards to the past week and also they have not been properly used the item "Not Applicable". The test-retest reliability ranged from 0.90 to 0.94 and the internal consistency ranged from 0.87 to 0.89. CONCLUSION: After the translation and cultural adaptation, it was obtained a reliable version of SPADI-Brazil.

title: The Brazilian version of Shoulder XXXX and Disability Index: translation, cultural adaptation and reliability.

answer: @entity1


abstract: Expression of the @entity2 am ( @entity1 -specific @entity3 dehydrogenase) gene is controlled by two upstream enhancer-like elements designated URSam alpha and URSam beta. URSam alpha is localized between - 1.3 and - 1.4 kb with respect to the major transcriptional start site. Deletion of a 90 bp sequence containing this element resulted in the loss of approximately 50% of normal @entity3 dehydrogenase expression. Gel mobility shift analysis indicated that a nuclear protein from @entity2 binds in a specific manner to sequences within the 90 bp fragment. We have now used a combination of ion-exchange and affinity chromatography to purify this nuclear protein, which we call Am Alpha Binding protein (AAB). The activity was monitored by gel shift analysis. The protein was purified more than 14,000-fold with a yield of approximately 7%. The purified protein appears as a heteromer on denaturing @entity4 gel electrophoresis, with only two strong bands visible in @entity0 -stained preparations. One band has an apparent molecular mass of 40 kDa, the other appears as a doublet with an apparent molecular mass of 30 kDa. DNAse I protection analysis indicated a protected region consisting of 30 bp, which contains a CCAAT pentanucleotide motif. Mutagenesis of the CCAAT motif abolished the binding of AAB to the DNA fragment.

title: Purification of a heteromeric CCAAT binding protein from XXXX .

answer: @entity2


abstract: Superolateral dislocation of the intact mandibular condyle (SDIMC) is rare. This case report focuses on a 15-year-old teenager who was involved in a motor vehicle accident as well a literature review regarding the SDIMC. Clinical examination demonstrated a diffuse @entity1 in the midfacial area and a left lateral deflection of the mandible, including an open bite and a crepitation in the symphyseal region. Three-dimensional computed tomography scans were taken, which presented a superolateral dislocation of the left mandibular condyle as well as panfacial @entity2 . The @entity0 was set in intermaxillary fixation for 2 weeks and underwent subsequent active jaw physiotherapy, the evaluation of which presented satisfactory results. This case study also presents a literature review, which demonstrated 21 well-documented cases of SDIMC. The @entity0 ' mean age was of 29 years. The male gender proved to be more prevalent, with road traffic collisions representing the most common form of accident. Type II, with unilateral dislocation, proved to be the most common. The mean reduction time was 7 days. The open methods were the most commonly used reduction methods. Mandible @entity2 was associated with dislocation in 82% of the cases, with other @entity2 appearing in only 23% of the cases. @entity0 follow up presented satisfactory results in 59% of the cases.

title: Superolateral dislocation of the intact mandibular condyle associated with panfacial XXXX : a case report and literature review.

answer: @entity2


abstract: The work is based on two years studied cases. It consists of 80 @entity0 between 35 and 80 years old with leg @entity3 (73.8% @entity0 and 26.2% @entity0 ). In 80% of @entity0 this affection is due to a @entity1 . In 10% of cases the cause was an @entity4 of the lower extremity. Lymphatic and extravascular diseases are rarely involved. A group of 54 @entity0 was treated with a traditional method. In the remaining 26 @entity0 we used fibrin glue. Leg @entity3 are an evolutive chronic pathology characterized by slow recovery. This means expensive social and therapeutic costs. From this point of view the treatment with fibrin glue, weekly applied, besides reducing @entity2 , has a favourable impact on the outcome, times of re-epithelialization are shortened.

title: [Treatment of leg XXXX with fibrin glue].

answer: @entity3