abstract: In a prospective, controlled, randomized trial of @entity3 prophylaxis, 400 @entity0 in a surgical intensive care unit received 50 mg @entity4 (n = 200) or 200 mg @entity5 (n = 200) daily. The drugs were administered continuously via an intravenous line. The mean duration of the treatment was 3.9 days. @entity0 were included in the study if no long-term ventilation was expected. In @entity0 with a stomach tube in place, the intragastric pH was determined every eight hours. Bleeding was defined as macroscopically visible. Along with @entity3 , the development of @entity2 was documented. The intragastric pH was less than 4 significantly more often in @entity0 treated with @entity4 . In @entity0 treated with @entity5 , six stress bleedings were observed, while in the @entity4 group three @entity3 episodes occurred. Seven of the nine @entity3 @entity0 were found to have a very high @entity3 risk. In mechanically ventilated @entity0 , a significantly higher risk of @entity1 was observed compared with non-ventilated @entity0 (18.0% vs 2.7%). Fourteen of the 20 @entity1 occurred in @entity0 treated with @entity5 . In ventilated @entity0 treated with @entity5 , the @entity1 rate was 28.6%, while in the @entity4 group the @entity1 rate reached only 9.1% (p less than 0.05). The increased frequency of @entity1 in @entity0 treated with @entity5 appears to be caused by overgrowth of gram-negative bacteria in the stomach. @entity4 provides adequate protection against @entity3 while also minimizing the danger of @entity1 caused by infection via the gastropulmonary route.

title: Prevention of @entity3 with XXXX or @entity4 and the risk of @entity1 .

answer: @entity5


abstract: In a prospective, controlled, randomized trial of @entity3 prophylaxis, 400 @entity0 in a surgical intensive care unit received 50 mg @entity4 (n = 200) or 200 mg @entity5 (n = 200) daily. The drugs were administered continuously via an intravenous line. The mean duration of the treatment was 3.9 days. @entity0 were included in the study if no long-term ventilation was expected. In @entity0 with a stomach tube in place, the intragastric pH was determined every eight hours. Bleeding was defined as macroscopically visible. Along with @entity3 , the development of @entity2 was documented. The intragastric pH was less than 4 significantly more often in @entity0 treated with @entity4 . In @entity0 treated with @entity5 , six stress bleedings were observed, while in the @entity4 group three @entity3 episodes occurred. Seven of the nine @entity3 @entity0 were found to have a very high @entity3 risk. In mechanically ventilated @entity0 , a significantly higher risk of @entity1 was observed compared with non-ventilated @entity0 (18.0% vs 2.7%). Fourteen of the 20 @entity1 occurred in @entity0 treated with @entity5 . In ventilated @entity0 treated with @entity5 , the @entity1 rate was 28.6%, while in the @entity4 group the @entity1 rate reached only 9.1% (p less than 0.05). The increased frequency of @entity1 in @entity0 treated with @entity5 appears to be caused by overgrowth of gram-negative bacteria in the stomach. @entity4 provides adequate protection against @entity3 while also minimizing the danger of @entity1 caused by infection via the gastropulmonary route.

title: Prevention of XXXX with @entity5 or @entity4 and the risk of @entity1 .

answer: @entity3


abstract: In a prospective, controlled, randomized trial of @entity3 prophylaxis, 400 @entity0 in a surgical intensive care unit received 50 mg @entity4 (n = 200) or 200 mg @entity5 (n = 200) daily. The drugs were administered continuously via an intravenous line. The mean duration of the treatment was 3.9 days. @entity0 were included in the study if no long-term ventilation was expected. In @entity0 with a stomach tube in place, the intragastric pH was determined every eight hours. Bleeding was defined as macroscopically visible. Along with @entity3 , the development of @entity2 was documented. The intragastric pH was less than 4 significantly more often in @entity0 treated with @entity4 . In @entity0 treated with @entity5 , six stress bleedings were observed, while in the @entity4 group three @entity3 episodes occurred. Seven of the nine @entity3 @entity0 were found to have a very high @entity3 risk. In mechanically ventilated @entity0 , a significantly higher risk of @entity1 was observed compared with non-ventilated @entity0 (18.0% vs 2.7%). Fourteen of the 20 @entity1 occurred in @entity0 treated with @entity5 . In ventilated @entity0 treated with @entity5 , the @entity1 rate was 28.6%, while in the @entity4 group the @entity1 rate reached only 9.1% (p less than 0.05). The increased frequency of @entity1 in @entity0 treated with @entity5 appears to be caused by overgrowth of gram-negative bacteria in the stomach. @entity4 provides adequate protection against @entity3 while also minimizing the danger of @entity1 caused by infection via the gastropulmonary route.

title: Prevention of @entity3 with @entity5 or @entity4 and the risk of XXXX .

answer: @entity1


abstract: In a prospective, controlled, randomized trial of @entity3 prophylaxis, 400 @entity0 in a surgical intensive care unit received 50 mg @entity4 (n = 200) or 200 mg @entity5 (n = 200) daily. The drugs were administered continuously via an intravenous line. The mean duration of the treatment was 3.9 days. @entity0 were included in the study if no long-term ventilation was expected. In @entity0 with a stomach tube in place, the intragastric pH was determined every eight hours. Bleeding was defined as macroscopically visible. Along with @entity3 , the development of @entity2 was documented. The intragastric pH was less than 4 significantly more often in @entity0 treated with @entity4 . In @entity0 treated with @entity5 , six stress bleedings were observed, while in the @entity4 group three @entity3 episodes occurred. Seven of the nine @entity3 @entity0 were found to have a very high @entity3 risk. In mechanically ventilated @entity0 , a significantly higher risk of @entity1 was observed compared with non-ventilated @entity0 (18.0% vs 2.7%). Fourteen of the 20 @entity1 occurred in @entity0 treated with @entity5 . In ventilated @entity0 treated with @entity5 , the @entity1 rate was 28.6%, while in the @entity4 group the @entity1 rate reached only 9.1% (p less than 0.05). The increased frequency of @entity1 in @entity0 treated with @entity5 appears to be caused by overgrowth of gram-negative bacteria in the stomach. @entity4 provides adequate protection against @entity3 while also minimizing the danger of @entity1 caused by infection via the gastropulmonary route.

title: Prevention of @entity3 with @entity5 or XXXX and the risk of @entity1 .

answer: @entity4


abstract: BACKGROUND: Lung protective ventilation using low end-inspiratory pressures and tidal volumes (VT) has been shown to impair alveolar recruitment and to promote derecruitment in @entity0 . The aim of the present study was to compare the effects of two different end-inspiratory pressure levels on alveolar recruitment, alveolar derecruitment and potential overdistention at incremental levels of positive end-expiratory pressure. METHODS: Sixteen adult @entity2 were randomized to be ventilated with a peak inspiratory pressure of either 35 cm @entity3 (P35, low VT) or 45 cm @entity3 (P45, high VT) after saline washout-induced @entity1 . Positive end-expiratory pressure ( @entity4 ) was increased in a stepwise manner from zero (ZEEP) to 7, 14 and 21 cm of @entity3 in hourly intervals. Tidal volume, initially set to 12 ml kg(-1), was reduced according to the pressure limits. Computed tomographic scans during end-expiratory and end-inspiratory hold were performed along with hemodynamic and respiratory measurements at each level of @entity4 . RESULTS: Tidal volumes for the two groups (P35/P45) were: 7.7 +/- 0.9/11.2 +/- 1.3 ml kg(-1) (ZEEP), 7.9 +/- 2.1/11.3 +/- 1.3 ml kg(-1) ( @entity4 7 cm @entity3 ), 8.3 +/- 2.5/11.6 +/- 1.4 ml kg(-1) ( @entity4 14 cm @entity3 ) and 6.5 +/- 1.7/11.0 +/- 1.6 ml kg(-1) ( @entity4 21 cm @entity3 ); P < 0.001 for differences between the two groups. Absolute nonaerated lung volumes during end-expiration and end-inspiration showed no difference between the two groups for given levels of @entity4 , while tidal-induced changes in nonaerated lung volume (termed cyclic alveolar instability, CAI) were larger in the P45 group at low levels of @entity4 . The decrease in nonaerated lung volume was significant for @entity4 14 and 21 cm @entity3 in both groups compared with ZEEP (P < 0.005). Over-inflated lung volumes, although small, were significantly higher in the P45 group. Significant @entity5 was noted in the P35 group despite increases in the respiratory rate. CONCLUSION: Limiting peak inspiratory pressure and VT does not impair alveolar recruitment or promote derecruitment when using sufficient levels of @entity4 .

title: Effects of end-inspiratory and end-expiratory pressures on alveolar recruitment and derecruitment in saline-washout-induced XXXX -- a computed tomography study.

answer: @entity1


abstract: This is an analysis of 304 @entity0 with invasive, previously untreated T1-T2 @entity1 of the glottic larynx treated with radiation therapy at the University of Florida between October 1964 and December 1984. All @entity0 had a minimum 2-year follow-up and 82% had at least 5 years of follow-up. @entity0 were excluded from the analysis of local control if they died within 2 years of treatment with the primary site continuously disease-free; all @entity0 were included in the analysis of treatment complications. @entity0 were staged according to the 1983 AJCC system. Stage T2 was subdivided into 2 groups as follows: T2a (normal mobility) and T2b (decreased mobility). The rates of local control with radiation therapy were as follows: T1, 159/171 (93%); T2a, 50/65 (77%); and T2b, 31/43 (72%). @entity0 were further divided into subsets based on T stage and the surgical procedure that would have been required to resect the lesion. Local control was noted to improve with higher doses and dose per fraction in 4 of 7 subsets. In 2 of 3 subsets where a dose-fractionation relationship was not observed, there were no local recurrences in 1 subset and only 2 local recurrences in the other. The overall incidence of serious complications was 5/304 (1.6%) and was associated with T stage and with increasing total dose and dose per fraction.

title: T1-T2 XXXX of the glottic larynx treated with radiation therapy: relationship of dose-fractionation factors to local control and complications.

answer: @entity1


abstract: Some authors recommend a routine "protective" antireflux procedure (ARP) in @entity1 @entity0 undergoing feeding gastrostomy (FG). Over 4 years, we performed FG in 107 @entity1 @entity0 aged 1 month to 16 years. Ninety-eight had preoperative radiological assessment for @entity3 ( @entity3 ), which was documented in 44, of whom 33 had FG plus ARP and 11 had FG alone. Seven of the 11 subsequently developed symptomatic @entity3 and 5 of them had a secondary ARP. Of the 54 @entity0 with no demonstrable @entity3 preoperatively, 3 @entity0 underwent FG plus ARP. The remaining 51 had FG alone. There was one @entity2 . Of the 50 surviving @entity0 , 22 developed symptomatic @entity3 and 17 of these had a subsequent ARP. Mean follow-up of 20.0 months showed that the risk of developing @entity3 after FG alone was not influenced by age, sex, indication for FG, underlying diagnosis, or method of gastrostomy. There was no significant difference in mortality and early morbidity between @entity0 undergoing FG alone and those having FG with simultaneous or subsequent ARP. Only 44% of our @entity0 in whom @entity3 was not demonstrated initially developed symptomatic @entity3 followed FG alone. This incidence does not justify a routine "protective" ARP.

title: Feeding XXXX @entity0 : is an antireflux procedure necessary?

answer: @entity1


abstract: Some authors recommend a routine "protective" antireflux procedure (ARP) in @entity1 @entity0 undergoing feeding gastrostomy (FG). Over 4 years, we performed FG in 107 @entity1 @entity0 aged 1 month to 16 years. Ninety-eight had preoperative radiological assessment for @entity3 ( @entity3 ), which was documented in 44, of whom 33 had FG plus ARP and 11 had FG alone. Seven of the 11 subsequently developed symptomatic @entity3 and 5 of them had a secondary ARP. Of the 54 @entity0 with no demonstrable @entity3 preoperatively, 3 @entity0 underwent FG plus ARP. The remaining 51 had FG alone. There was one @entity2 . Of the 50 surviving @entity0 , 22 developed symptomatic @entity3 and 17 of these had a subsequent ARP. Mean follow-up of 20.0 months showed that the risk of developing @entity3 after FG alone was not influenced by age, sex, indication for FG, underlying diagnosis, or method of gastrostomy. There was no significant difference in mortality and early morbidity between @entity0 undergoing FG alone and those having FG with simultaneous or subsequent ARP. Only 44% of our @entity0 in whom @entity3 was not demonstrated initially developed symptomatic @entity3 followed FG alone. This incidence does not justify a routine "protective" ARP.

title: Feeding @entity1 XXXX : is an antireflux procedure necessary?

answer: @entity0


abstract: Persistent clinical @entity5 (i.e., urinary protein excretion greater than 0.5 g/24 h) is an ominous development in a @entity0 with @entity1 . It eventually leads to a decline in the glomerular filtration rate and ultimately to @entity4 or premature cardiovascular mortality. Progression of @entity2 appears to be related to arterial blood pressure and protein intake and is primarily independent of the metabolic state. More sensitive immunoassays for detecting low concentrations of albumin in urine have led to recognition of subclinical increases in albumin excretion rates in nonclinically proteinuric @entity1 @entity0 , a phenomenon named microalbuminuria. Studies have shown that @entity0 with microalbuminuria have a significantly increased risk for clinical @entity5 and cardiovascular mortality. Microalbuminuria is rarely found during the first 5 yr of a @entity0 's @entity1 , suggesting that it is a sign of early @entity2 rather than a marker for susceptibility to it. In @entity0 with @entity7 ( @entity7 ), an association has been found between microalbuminuria and @entity3 , but this relationship needs further investigation. In @entity0 with @entity6 ( @entity6 ), this subclinical form of @entity5 is associated with poor metabolic control and, more important, with marginal elevation of blood pressure. Correction of @entity8 by intensified insulin treatment might arrest progression to persistent clinical @entity5 ; moreover, restricted protein intake and lowering of blood pressure have been shown to reduce the albumin excretion rate.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Etiology and prognostic significance of albuminuria in XXXX .

answer: @entity1


abstract: OBJECTIVE: To see whether stress could be alleviated in @entity1 being treated for early @entity0 . DESIGN: Controlled randomised trial lasting six weeks. SETTING: Outpatient radiotherapy department in a teaching hospital. @entity1 : One hundred fifty four @entity1 with @entity0 or II after first session of six week course of radiotherapy, of whom 15 dropped out before end of study. INTERVENTION: @entity1 saw one of two researchers once a week for six weeks. Controls were encouraged to talk about themselves; relaxation group was taught concentration on individual muscle groups; relaxation and imagery group was also taught to imagine peaceful scene of own choice to enhance relaxation. Relaxation and relaxation plus imagery groups were given tape recording repeating instructions and told to practise at least 15 minutes a day. END POINT: Improvement of mood and of @entity3 and @entity2 on self rating scales. MEASUREMENTS AND MAIN RESULTS: Initial scores for profile of mood states and Leeds general scales for @entity3 and @entity2 were the same in all groups. At six weeks total mood disturbance score was significantly less in the intervention groups, @entity1 in the combined intervention group being more relaxed than those receiving relaxation training only; mood in the control group was worse. @entity1 aged 55 and over benefited most. There was no difference in Leeds scores among the groups. CONCLUSIONS: @entity1 with early @entity0 benefit from relaxation training.

title: Relaxation and imagery in the treatment of XXXX .

answer: @entity0


abstract: A recent study from a private endodontic practice compared "prophylactic" antibiotic (high-dose, 1-day) regimens of @entity7 and @entity5 (base or @entity6 ) for @entity0 who had asymptomatic teeth with @entity1 and associated periapical radiolucent lesions (PN/PL). A 2.2% flare-up incidence was found, with no statistically significant differences for @entity3 (0.0%), base (2.9%), and @entity6 (3.8%). No @entity2 responses occurred, and gastrointestinal side effects were found primarily with the erythromycins (12.4%). To ascertain whether or not similar results would occur with student operators in a dental school clinic population, the current study was undertaken. One-hundred ninety-five @entity0 with quiescent PN/PL were randomly given either @entity7 or @entity5 (base or @entity6 ). A 2.6% flare-up incidence was found, with no statistically significant differences for @entity3 (3.1%), base (1.5%), and @entity6 (3.1%). No @entity2 responses occurred, and GI side effects were found primarily with the @entity8 (17.7%). As can be seen, the results were very similar to those of the recent endodontic practice study. Hence, it can be concluded that the results of the previous endodontic practice study were not unique to any one clinician or method. A comparison was also made between the "prophylactic" @entity3 group of the current study and the placebo control group of our previous dental school clinic, student operator study (in which the methods, population, and regimen were almost identical to those of the current study). The results showed that the "prophylactic" @entity3 group had significant fewer flare-ups and non-flare-up-associated swelling and @entity4 than did the placebo group. In view of these findings and those from studies from the literature in which "prophylactic" antibiotics were not used, it is our opinion that the antibiotic regimens used in the current study should be a component of clinical endodontic therapy for quiescent PN/PL.

title: A prospective randomized trial on efficacy of antibiotic prophylaxis in asymptomatic teeth with XXXX and associated periapical pathosis.

answer: @entity1


abstract: IgM @entity1 (IgMN) causes @entity2 and is characterized by IgM mesangial deposits. It is speculated that these deposits are derived from circulating IgM aggregates or immune complexes, either of which would have a molecular weight heavier than that of normal IgM. To test this hypothesis the sera of 11 @entity0 with IgMN, five @entity0 with @entity2 of other etiologies, and 13 normal controls were analysed for such heavy IgM. The serum samples were passed over a Biogel A5M molecular sieve column and the fractions were tested for IgM concentration by enzyme linked immunosorbent assay (ELISA). The column effluent from the void volume to the IgM peak was divided into four equal regions, and the average IgM concentrations in each region were compared. The IgMN group had significantly higher IgM concentrations than normal controls in the heaviest region (0.81 +/- 0.84 vs. 0.32 +/- 0.17 micrograms/ml; P = 0.01) and in the lightest region (95.8 +/- 59.5 vs. 46.3 +/- 41.2 micrograms/ml; P = 0.02). Although the IgMN group appeared to have about double the IgM levels of the @entity2 control group in all four regions, this was only significant in the lightest (19S) region. In serum samples from two IgMN @entity0 methods known to break antigen antibody bonds eliminated the heavy IgM; in one case we used gel filtration in @entity3 and in another ultracentrifugation at pH 2.8. In addition, the heavy IgM in this second @entity0 exhibited complement fixation activity in a sandwich ELISA for IgM-C3 complexes. We conclude that IgMN @entity0 have circulating heavy IgM, which by preliminary studies probably consists of complement fixing IgM immune complexes.

title: Circulating heavy IgM in IgM XXXX .

answer: @entity1


abstract: The antiarrhythmic effects of @entity3 were evaluated in 9 @entity0 with paroxysmal @entity2 ( @entity2 ) @entity1 and 17 @entity0 with @entity1 . An electrophysiologic study was performed before and after intravenous @entity3 , 2 mg/kg body weight, was infused over 15 minutes and was followed by a maintenance infusion of 1.6 mg/kg given over 1 hour to 26 @entity0 and during oral treatment to 15. Treatment with oral @entity3 was continued for 14 +/- 5 months. Intravenous @entity3 terminated @entity2 @entity1 by blocking the retrograde fast pathway conduction in 7 of 7 @entity0 and @entity1 by blocking retrograde conduction in the extranodal pathway in 10 of 10 @entity0 . @entity2 @entity1 and @entity1 were noninducible in 8 of 9 @entity0 (90%, p less than 0.001) and 11 of 17 @entity0 (65%, p less than 0.001), respectively. Long-term treatment with oral @entity3 suppressed @entity2 @entity1 and @entity1 in 8 of 9 @entity0 (90%, p less than 0.001) and 11 of 17 @entity0 (65%, p less than 0.001), respectively. A favorable outcome was associated with block in the accessory pathway after intravenous @entity3 and noninducibility during oral treatment. Recurrences preferentially occurred in the younger @entity0 . @entity3 is effective in the acute and long-term management of paroxysmal supraventricular reentry @entity1 by suppressing conduction through the retrograde fast limb of the @entity1 circuit. The clinical effect can be predicted by electrophysiologic testing.

title: Electrophysiologic and clinical effects of XXXX for recurrent paroxysmal supraventricular tachycardia.

answer: @entity3


abstract: BACKGROUND: In developed countries one-third of the population is infected with the gastric pathogen @entity2 . In the early stages of @entity2 -induced @entity3 , typical symptoms include @entity0 and mucus depletions. Artificial mucus depletion was generated, demonstrating both consequent irritation and recovery processes in the mucosa. METHODS: The mucus depletion was examined by removing a small cylinder of mucus from the surface of the explanted @entity1 corpus mucosa, leaving the epithelial surface intact. pH microelectrodes were inserted into the mucosa in vitro, measuring the epicellular mucus pH, the pH(i) of the underlying epithelial cells and the pH inside the gastric glands during mucus regeneration. Using infrared microscopy, the same process of mucus layer renewal was followed in anaesthetized animals. RESULTS: The depletion exposed the tissue surface to low luminal pH levels. At a luminal pH of 2.5, a decrease was observed in the crypt outlet pH and surface cell pH(i), while deeper cells were less affected. However, a subsequent neutralization in the deep gland lumen was found. During the repair process, a quarter of the mucus layer was regenerated within the first 5 min. This newly secreted mucus formed a structure similar to that before depletion. Within 45 min, pH(i) and tissue-near pH values had fully recovered. CONCLUSION: Following mucus depletion, there is a decrease in surface cell pH(i) and crypt outlet pH values. The repair process is then characterized by extensive mucus secretion and local cessation of acid secretion.

title: Recovery from gastric mucus depletion in the intact XXXX mucosa.

answer: @entity1


abstract: AIMS: The aim of this research was to evaluate the prevalence of @entity3 in a sample of Iranian nursing students. DESIGN AND MEASUREMENTS: Four hundred nursing students (85.25% were females and 14.25% were male) were assessed by a confidential questionnaire based on DSM-IV, which was distributed, completed by the students and collected in the same session. FINDINGS: Mean age of the females was 20.3 and of males was 22.8. Of the subjects, 27.3% (21.4% of females and 61% of males) reported usage of substance(s) once or more sometime during their lives: cigarette (25.3%), @entity1 (5.8%), @entity7 (8.5%), @entity5 (1.5%), hashish (1.5%), marijuana (0.8%) and @entity4 (0.5%). Only 3.8% of the @entity0 (1.8% of females and 15.3% of males) reported still using substances: cigarettes (3.3%), @entity1 (1.7%), @entity7 (0.8%), @entity5 (0.5%) and marijuana (0.3%). About 11.8% of the subjects (10% of females and 22% of males) reported using of substances occasionally (at least once a month): cigarette (10.8%), @entity1 (3.5%), @entity7 (4.3%), @entity5 (0.5%) and hashish (0.3%). Some used or were using more than one substance. CONCLUSIONS: Substance use was significantly related to sex: higher among males than females. @entity2 and @entity7 were found to be the most prevalent form of substance use among students. Pleasurable purposes, habit, need (to avoid withdrawal symptoms) and tension were the major reasons for substance use. There was no report of psychedelics use. These results are, however, different from those studies carried out in the west, although there is some overlap. Cultural attitudes toward substance use quite likely affect the types and patterns of use. These findings can be considered when planning preventive and therapeutic programmes. RELEVANCE TO CLINICAL PRACTICE: Substance use can reduce scientific progress and @entity6 achievement of nursing students; therefore, authorities of the university must be able to assess the extent of the problem, understand the contributing factors, recognize signs and symptoms, and use educational interventions in identifying and preventing substance dependency.

title: XXXX : prevalence in a sample of nursing students.

answer: @entity3


abstract: OBJECTIVES: To investigate the relationship between metabolic markers of @entity5 and cognitive function in normal older adults. DESIGN: Cross-sectional study. SETTING: Queen's University and St. Mary's of the Lake Hospital, Kingston, Ontario, Canada. @entity0 : Two hundred eighty-one cognitively normal, community-dwelling @entity0 aged 65 and older. MEASUREMENTS: Serum cobalamin, red blood cell @entity3 , @entity7 , @entity2 , and @entity6 were determined. Cognitive instruments included the California Verbal Learning Test, @entity1 Rating Scale, and the Stroop Neuropsychological Screening Inventory (Stroop). RESULTS: Serum levels of @entity7 had a significant negative correlation with recall, learning, and discriminability (factor 1) of the California Verbal Learning Test after adjusting for age and sex (beta=-0.138, P=.019). Subjects with elevated @entity7 had significantly lower scores (factor 1) than subjects with normal @entity7 (P<.01). Bivariate analysis showed significant correlations between levels of @entity2 and the Stroop score and between @entity4 , @entity6 , and @entity2 and some scores of the California Verbal Learning Test, but these relationships did not remain significant after multivariate analysis. Subjects with high @entity2 (tHcy) had lower Stroop scores than subjects with normal tHcy (P<.05). No biochemical parameters were associated with the @entity1 Rating Scale scores. CONCLUSION: This study indicates that, in normal elderly subjects, some cognitive scores are related to serum @entity7 and possibly @entity2 .

title: Metabolic markers of XXXX and cognitive function in normal older adults.

answer: @entity5


abstract: The use of temporary natural henna painting for body adornment and hair dyeing is very common in several countries of the Indian subcontinent, Middle East, and North Africa, and the fad is spreading in other parts of the world. Several cases of @entity5 ( @entity6 ) contaminated, temporary traditional/natural henna induced sensitization and @entity2 have been reported, along with occasional serious long term and rare fatal consequences. We report here a 17-year-old @entity0 with blisters over her hands of five-days duration that appeared within 72 hours of applying a temporary henna paint to her hands during a social occasion. Similar lesions were noted on her face. She had previously applied black henna only once, a year earlier without developing any lesions. Clinical diagnosis of @entity4 ( @entity4 ) was made. After a short course of oral @entity3 , topical @entity7 furaote 1.0% cream, and oral antihistamines, the lesions healed completely over the next four weeks leaving @entity1 . Patch testing done with standard European battery, @entity6 1% in petrolatum, and commercially available natural henna powder revealed a 3+ reaction to @entity6 at 48 hours. No reaction was seen at the natural henna site. Awareness of the condition among physicians and the public and regulation regarding warnings of the risks of using such products is urgently warranted.

title: Acute XXXX due to @entity5 after temporary henna painting.

answer: @entity4


abstract: The use of temporary natural henna painting for body adornment and hair dyeing is very common in several countries of the Indian subcontinent, Middle East, and North Africa, and the fad is spreading in other parts of the world. Several cases of @entity5 ( @entity6 ) contaminated, temporary traditional/natural henna induced sensitization and @entity2 have been reported, along with occasional serious long term and rare fatal consequences. We report here a 17-year-old @entity0 with blisters over her hands of five-days duration that appeared within 72 hours of applying a temporary henna paint to her hands during a social occasion. Similar lesions were noted on her face. She had previously applied black henna only once, a year earlier without developing any lesions. Clinical diagnosis of @entity4 ( @entity4 ) was made. After a short course of oral @entity3 , topical @entity7 furaote 1.0% cream, and oral antihistamines, the lesions healed completely over the next four weeks leaving @entity1 . Patch testing done with standard European battery, @entity6 1% in petrolatum, and commercially available natural henna powder revealed a 3+ reaction to @entity6 at 48 hours. No reaction was seen at the natural henna site. Awareness of the condition among physicians and the public and regulation regarding warnings of the risks of using such products is urgently warranted.

title: Acute @entity4 due to XXXX after temporary henna painting.

answer: @entity5


abstract: Although it is well known that the skin in @entity0 with @entity1 becomes drier in winter, the mechanisms of winter deterioration of dry skin are not fully understood. Our purpose was to determine whether residual washing detergent in @entity2 clothes plays a role in the winter deterioration of atopic dry skin. We studied 148 Japanese @entity0 with @entity1 who visited our dermatology clinic during winter months. They wore @entity2 underwear, which they had washed in cold tap water. We examined the distribution of dry skin on their trunks. We then asked them to stop washing their clothes with common anionic, additive-enriched detergents, and to use a nonionic, additive-reduced detergent for a period of two weeks. Photographs of 2 or 3 representative dry skin sites on the trunk were taken before and after the trial. By comparing the before-after trial photographs, the severity of dry skin at the end of the trial was assessed on a 5-point scale ranging from markedly improved to worsened. Of the 148 @entity0 examined, 115 (78%) had widespread or localized dry skin on the trunk. The dryness of the skin was prominent around the shoulders. Of these 115 @entity0 , 87 (76%) showed marked or moderate improvement of dry skin after the two-weeks of use of the nonionic, additive-reduced washing detergent. No @entity0 showed worsening of the dry skin. These results suggest that residues of common washing detergents in @entity2 underclothes play an important role in the winter deterioration of dry skin in @entity0 with @entity1 who use cold tap water for washing their clothes.

title: Residual washing detergent in XXXX clothes: a factor of winter deterioration of dry skin in @entity1 .

answer: @entity2


abstract: Although it is well known that the skin in @entity0 with @entity1 becomes drier in winter, the mechanisms of winter deterioration of dry skin are not fully understood. Our purpose was to determine whether residual washing detergent in @entity2 clothes plays a role in the winter deterioration of atopic dry skin. We studied 148 Japanese @entity0 with @entity1 who visited our dermatology clinic during winter months. They wore @entity2 underwear, which they had washed in cold tap water. We examined the distribution of dry skin on their trunks. We then asked them to stop washing their clothes with common anionic, additive-enriched detergents, and to use a nonionic, additive-reduced detergent for a period of two weeks. Photographs of 2 or 3 representative dry skin sites on the trunk were taken before and after the trial. By comparing the before-after trial photographs, the severity of dry skin at the end of the trial was assessed on a 5-point scale ranging from markedly improved to worsened. Of the 148 @entity0 examined, 115 (78%) had widespread or localized dry skin on the trunk. The dryness of the skin was prominent around the shoulders. Of these 115 @entity0 , 87 (76%) showed marked or moderate improvement of dry skin after the two-weeks of use of the nonionic, additive-reduced washing detergent. No @entity0 showed worsening of the dry skin. These results suggest that residues of common washing detergents in @entity2 underclothes play an important role in the winter deterioration of dry skin in @entity0 with @entity1 who use cold tap water for washing their clothes.

title: Residual washing detergent in @entity2 clothes: a factor of winter deterioration of dry skin in XXXX .

answer: @entity1


abstract: A good result from the heart-lung transplantation depends on the quality of the preservation of cardiopulmonary transplants. To determine the functional and pathological status of the @entity4 after preservation for several hours, we performed 10 heterologous heart-lung transplantations in @entity2 (weight 13.5 kg) under extracorporeal circulation. Weight and length compatibility between donor and receiver was ensured. Measurements of hemodynamics, lung mechanics and blood gases were performed in the donor and in the receiver before the transplantation, and in the receiver after heart-lung reimplantation. Histological studies were carried out by biopsy on the heart and on the lung of the donor before removal, at the beginning of the preservation at low temperature, after 3 h of @entity0 in cold, and every hour after recirculation in the @entity4 . Myocardial preservation was conducted with cold cardioplegia at 4 degrees C (Ringer lactate solution with high @entity5 ). Lung preservation was achieved by injecting a @entity7 -Collins solution at 4 degrees C, with addition of @entity2 plasma, into the pulmonary artery; during the whole ischemic phase, the lung parenchyma was maintained at 0 degrees C, and inflated at a 10 cm @entity6 pressure. After transplantation, we observed that cardiac output was low in all cases, with normal or subnormal pulmonary arterial pressure. Dynamic lung compliance was very low immediately after transplantation, and increased when restarting the circulation, but deteriorated again after several hours. At the same time alveolo-arterial O2 pressure difference and arterio-alveolar @entity3 pressure difference progressively increased, due to the extensive @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Cardiorespiratory function and pathological findings in XXXX reimplanted after hypothermic preservation.

answer: @entity4


abstract: Because of the high rate of response in colorectal liver metastases, intra-arterial chemotherapy was studied in 14 @entity1 with isolated @entity0 . After extrahepatic metastasization had been ruled out, a catheter was placed surgically and connected to a cytostatic pump (in two cases) or to a subcutaneous infusion chamber (in 12 cases). Every four to six weeks, the @entity1 with an infusion chamber received a modified FAM treatment ( @entity7 , @entity5 , @entity6 ) for three days continuously. In 11 out of 14 @entity1 (79%) a clear @entity2 reduction was observed (duration of remission 11 months). In an average of six cycles of chemotherapy administered, a total of 50% of the @entity1 manifested local side effects (including two cases of @entity3 , one case of @entity4 ). Systemic side effects were negligible. Termination of therapy was necessitated by three catheter tip migrations and two @entity3 . Extrahepatic metastases occurred in six @entity1 . Here, the average latency period between diagnosis of the @entity2 and that of liver metastasis was significantly shorter (x = 9 months) than in the other @entity1 (x = 39 months). Intra-arterial chemotherapy thus represents a therapeutic method which, although complicated, is extremely effective in selected @entity1 with isolated @entity0 . A final evaluation must be subject to a randomized comparison with a systemic therapy.

title: [Regional therapy of isolated liver metastases from XXXX ].

answer: @entity0


abstract: In the 45 years since the first description of @entity3 acetyltransferase ( @entity4 ; EC 2.3.1.6.), significant progress has been made in characterizing the molecular properties of this important neurotransmitter synthetic enzyme. We are now on the verge of understanding its genetic regulation and biological function(s). The @entity1 cDNA has been cloned, sequenced, and expressed in both a eucaryotic and a procaryotic system. The levels of @entity4 specific mRNA have been determined during @entity1 development. Monoclonal and polyclonal antibodies have been produced to the enzyme from a variety of sources and used for biochemical and immunocytochemical studies. Two well characterized genetic systems have identified the @entity4 gene and described a series of useful alleles. As a nervous system specific protein expressed only in the subset of neurons using @entity2 as a neurotransmitter, @entity4 is a good model for uncovering the processes and factors responsible for regulating genes involved in neurotransmitter phenotype selection and maintenance. Recent studies have described the purification of a cholinergic factor from muscle conditioned medium and indicated the potential importance of nerve growth factor (NGF) for regulating @entity4 expression in the central nervous system. These factors, or ones remaining to be discovered, may be involved in the etiology or disease process of @entity5 such as @entity0 .

title: Molecular biology and neurobiology of XXXX acetyltransferase.

answer: @entity3


abstract: OBJECTIVE: To evaluate the efficacy of @entity3 as an auxiliary therapeutic tool to the antibiotics in hospitalized @entity0 with @entity4 . METHODS: A retrospective clinical comparative study was undertaken with @entity0 from a pediatric ward affected by laboratory proved @entity4 at a university hospital. Cases of @entity0 in state of shock at admission or deceased in the first 24 hours were excluded. During the period from 1987 to 1989 33 @entity0 were treated only with antibiotics (group A), while from 1990 to 1993 other 66 @entity0 received additionally @entity3 (12mg/m2/24h) by intravenous route during four days beginning at the admission to the hospital (group B). The two groups were evaluated at baseline through prognostic scores and analysis of their clinical and laboratorial characteristics obtained from data recorded at the admission. The parameters to evaluate @entity3 efficacy were the comparative number of @entity1 detected at the hospital, and the liquoric profile (leukocyte count, @entity2 and protein content) verified between day 9 and day 11 of hospitalization. RESULTS: The profile of the two groups (A and B) were homogeneously evaluated by the illness severity scores and their clinical and laboratorial characteristics. Nine complications were recognized in group A (27.2%) and 21 (31.8%) among those of group B, difference not significant. Likewise, there were not observed liquoric differences between the two groups related to the chimiocytologic pattern. CONCLUSIONS: No effect of @entity3 therapy to prevent neurologic and @entity4 was observed during hospitalization. Similarly no favorable effect in relation to the liquoric pattern verified between day 9 and day 11 of hospitalization was recognized.

title: [Evaluation of the therapeutic efficacy of @entity3 in XXXX ]

answer: @entity4


abstract: OBJECTIVE: To evaluate the efficacy of @entity3 as an auxiliary therapeutic tool to the antibiotics in hospitalized @entity0 with @entity4 . METHODS: A retrospective clinical comparative study was undertaken with @entity0 from a pediatric ward affected by laboratory proved @entity4 at a university hospital. Cases of @entity0 in state of shock at admission or deceased in the first 24 hours were excluded. During the period from 1987 to 1989 33 @entity0 were treated only with antibiotics (group A), while from 1990 to 1993 other 66 @entity0 received additionally @entity3 (12mg/m2/24h) by intravenous route during four days beginning at the admission to the hospital (group B). The two groups were evaluated at baseline through prognostic scores and analysis of their clinical and laboratorial characteristics obtained from data recorded at the admission. The parameters to evaluate @entity3 efficacy were the comparative number of @entity1 detected at the hospital, and the liquoric profile (leukocyte count, @entity2 and protein content) verified between day 9 and day 11 of hospitalization. RESULTS: The profile of the two groups (A and B) were homogeneously evaluated by the illness severity scores and their clinical and laboratorial characteristics. Nine complications were recognized in group A (27.2%) and 21 (31.8%) among those of group B, difference not significant. Likewise, there were not observed liquoric differences between the two groups related to the chimiocytologic pattern. CONCLUSIONS: No effect of @entity3 therapy to prevent neurologic and @entity4 was observed during hospitalization. Similarly no favorable effect in relation to the liquoric pattern verified between day 9 and day 11 of hospitalization was recognized.

title: [Evaluation of the therapeutic efficacy of XXXX in @entity4 ]

answer: @entity3


abstract: Little is known about radiosensitization produced by @entity3 (IUDR) with high linear energy transfer radiation. Likewise, the effect of IUDR on repair of sublethal or potentially lethal damage is unclear. A series of in vitro experiments was performed examining these aspects of IUDR radiosensitization. @entity0 T1 cells were grown in the presence of 3.0 micromolar IUDR for 72 hours (approximately three doubling times), an exposure which resulted in minimal @entity2 to unirradiated cells. As the cells entered plateau phase they were exposed to X rays and a variety of heavy ion beams. Sensitization was found to decrease as linear energy transfer (LET) increased. No sensitization took place in an extremely high LET Lanthanum ion beam (1000 keV/micrometer). However, IUDR produced significant sensitization in the Neon ion beam currently used to treat @entity1 @entity0 at Lawrence Berkeley Laboratory. Sensitization enhancement ratios at the 40% cell survival level were found to be 1.8 for X rays, 1.5 for the proximal Bragg peak of the clinical Neon beam, and 1.3 for the distal peak of the clinical Neon beam. Cell survival curves fitted to the linear-quadratic model showed IUDR significantly increased the value of the linear component (alpha) in beams with LETs below 40 keV/micron. The value of the quadratic component (beta) was unaffected by IUDR, regardless of LET. Split-dose experiments with both X rays and proximal peak Neon ions revealed IUDR did not affect sublethal damage repair. Similarly, delayed-plating experiments showed IUDR did not affect repair of potentially lethal damage. In contrast to cells unexposed to IUDR, IUDR-treated cells showed near-equal levels of cell killing throughout the extended Bragg peak of the clinical Neon beam. These findings suggest that the addition of IUDR to @entity4 ion radiotherapy could enhance the therapeutic ratio of the clinical Neon beam.

title: Radiosensitization produced by XXXX with high linear energy transfer heavy ion beams.

answer: @entity3


abstract: Administration of an elemental diet to @entity0 given @entity2 ( @entity3 ), 20 mg/kg intraperitoneally (ip), results in 100% mortality from severe @entity6 . Previous studies indicate that @entity1 ( @entity9 ), which is not present in elemental diets, is the preferred oxidative substrate for the gut and may facilitate intestinal recovery after injury. This study investigated the effects of a @entity1 -supplemented elemental diet ( @entity9 -ED) on nutritional status, intestinal morphometry, bacterial translocation and survival in this lethal model of @entity5 . Three experiments were performed. In the first experiment, @entity0 received an intragastric elemental diet supplemented with either 2% @entity9 or an equivalent amount of @entity7 (Control). After 4 days animals received either @entity3 , 20 mg/kg ip, or saline ip and were killed 3 days later. The @entity9 -ED resulted in significantly decreased weight loss, improved @entity4 retention, and increased mucosal weight, protein, and DNA content of the jejunum and colon. In the second experiment @entity0 were assigned to diet as in the first experiment, but all animals received @entity3 . Control diet animals died within 120 hrs of @entity3 administration. The @entity9 -ED group had significantly longer survival time and decreased mortality. In the third experiment animals were assigned to diet and @entity3 as in the first experiment. Ninety-six hrs later aortic blood cultures revealed enteric @entity8 in animals administered @entity3 . @entity9 -ED resulted in a significant reduction in the incidence of @entity8 . These experiments showed that a @entity9 -ED significantly improved nutritional status, decreased @entity5 , decreased bacterial translocation, and resulted in improved survival in a lethal model of @entity6 .

title: Effect of a @entity1 -supplemented enteral diet on @entity2 -induced XXXX .

answer: @entity6


abstract: Administration of an elemental diet to @entity0 given @entity2 ( @entity3 ), 20 mg/kg intraperitoneally (ip), results in 100% mortality from severe @entity6 . Previous studies indicate that @entity1 ( @entity9 ), which is not present in elemental diets, is the preferred oxidative substrate for the gut and may facilitate intestinal recovery after injury. This study investigated the effects of a @entity1 -supplemented elemental diet ( @entity9 -ED) on nutritional status, intestinal morphometry, bacterial translocation and survival in this lethal model of @entity5 . Three experiments were performed. In the first experiment, @entity0 received an intragastric elemental diet supplemented with either 2% @entity9 or an equivalent amount of @entity7 (Control). After 4 days animals received either @entity3 , 20 mg/kg ip, or saline ip and were killed 3 days later. The @entity9 -ED resulted in significantly decreased weight loss, improved @entity4 retention, and increased mucosal weight, protein, and DNA content of the jejunum and colon. In the second experiment @entity0 were assigned to diet as in the first experiment, but all animals received @entity3 . Control diet animals died within 120 hrs of @entity3 administration. The @entity9 -ED group had significantly longer survival time and decreased mortality. In the third experiment animals were assigned to diet and @entity3 as in the first experiment. Ninety-six hrs later aortic blood cultures revealed enteric @entity8 in animals administered @entity3 . @entity9 -ED resulted in a significant reduction in the incidence of @entity8 . These experiments showed that a @entity9 -ED significantly improved nutritional status, decreased @entity5 , decreased bacterial translocation, and resulted in improved survival in a lethal model of @entity6 .

title: Effect of a @entity1 -supplemented enteral diet on XXXX -induced @entity6 .

answer: @entity2


abstract: Administration of an elemental diet to @entity0 given @entity2 ( @entity3 ), 20 mg/kg intraperitoneally (ip), results in 100% mortality from severe @entity6 . Previous studies indicate that @entity1 ( @entity9 ), which is not present in elemental diets, is the preferred oxidative substrate for the gut and may facilitate intestinal recovery after injury. This study investigated the effects of a @entity1 -supplemented elemental diet ( @entity9 -ED) on nutritional status, intestinal morphometry, bacterial translocation and survival in this lethal model of @entity5 . Three experiments were performed. In the first experiment, @entity0 received an intragastric elemental diet supplemented with either 2% @entity9 or an equivalent amount of @entity7 (Control). After 4 days animals received either @entity3 , 20 mg/kg ip, or saline ip and were killed 3 days later. The @entity9 -ED resulted in significantly decreased weight loss, improved @entity4 retention, and increased mucosal weight, protein, and DNA content of the jejunum and colon. In the second experiment @entity0 were assigned to diet as in the first experiment, but all animals received @entity3 . Control diet animals died within 120 hrs of @entity3 administration. The @entity9 -ED group had significantly longer survival time and decreased mortality. In the third experiment animals were assigned to diet and @entity3 as in the first experiment. Ninety-six hrs later aortic blood cultures revealed enteric @entity8 in animals administered @entity3 . @entity9 -ED resulted in a significant reduction in the incidence of @entity8 . These experiments showed that a @entity9 -ED significantly improved nutritional status, decreased @entity5 , decreased bacterial translocation, and resulted in improved survival in a lethal model of @entity6 .

title: Effect of a XXXX -supplemented enteral diet on @entity2 -induced @entity6 .

answer: @entity1


abstract: Gastrointestinal endoscopy was performed in two @entity1 @entity0 using inhaled corticosteroid who complained of odynophagia. The endoscopic finding was high grade with white moss (Grade III) in both @entity0 . @entity3 is often recognized in bronchial @entity2 @entity0 receiving long-term @entity4 (FP) dry powder (Diskhaler) inhalation. We therefore examined the complicated context of @entity3 in @entity0 with long-term FP inhalation. Out of 20 bronchial @entity2 @entity0 who had been using FP inhalation long-term, seven showed signs of @entity3 . Three @entity0 had mild grade (Grade I), one middle grade (Grade II) and three high grade (Grade III) candidiasis, with a frequency of 35%. This rate is higher than the usual spontaneous occurrence rate of @entity3 , and it is suggested that inhalation of corticosteroid medication can penetrate into the esophagus after deep inhalation. We tested this hypothesis in two studies. 1) To measure the esophageal concentration of FP, four healthy adults inhaled 200 microg FP once. Right after inhalation, FP concentration in the esophageal washing fluid was 3.3 microg. On another day, 30 minutes after the same dose of inhaled FP, one FP concentration in the esophageal washing fluid was 0.67 microg (immediately laydown), and another was 0.11 microg (remained standing). This indicates that even though FP dissipates quickly, it remains in the esophagus 30 minutes after inhalation. 2) We observed the process in one @entity0 with high grade (Grade III) @entity3 . The time of inhalation was changed from just after getting up and just before going to bed to before breakfast and before dinner. Under this regimen, the signs of @entity3 improved from high to middle grade. CONCLUSION: If @entity2 @entity0 do not go to sleep immediately after FP inhalation, the remaining FP in the esophagus decreases rapidly, thereby decreasing the risk of @entity3 . In addition, by changing the FP inhalation times to before breakfast and dinner, the remaining FP in the esophagus is washed away and does not remain in the esophagus. Therefore, this study, which avoided inhalation before going to bed, provides useful information for the prevention and improvement of @entity3 .

title: [ XXXX as complication of inhaled steroid therapy].

answer: @entity3


abstract: BACKGROUND: The actual conditions regarding immediate type @entity3 have not been fully understood. Appropriate countermeasures have not been taken so far. The objective of our research is to identify the actual conditions of immediate type @entity3 in Japan for the purpose of contributing to future practices. SUBJECT: We conducted a survey on the @entity0 in collaboration with 2689 domestic hospitals which have pediatrics and more than 100 beds. We focused on these cases who presented with symptoms of @entity1 within 60 minutes of the intake of any offending food. RESULT: 60.4% of collaborators returned the questionnaire. We investigated 1420 cases in 498 hospitals. Average age of cases was 6.7+/-13.1 (Mean+/-SD). Ages not more than 8 years-old comprised 80.1% of the whole population. The most common offending foods were eggs, milk products, @entity2 , buckwheat, fish and fruits. In addition, offending foods varied depending on age. The clinical symptoms appeared at 24.2 minutes+/-19.4 minutes (Mean+/-SD) after the intake of offending foods. The most common clinical symptom was observed on the skin and respiratory organs. CONCLUSION: Based on the results of this study, the Ministry of Health, Labor and Welfare amended the ministerial ordinance concerning the @entity1 food labeling system. Five major offending foods (eggs, milk, @entity2 , buckwheat, and peanuts) were designated as ingredients to be specified on the label.

title: [The national survey of immediate type of XXXX ].

answer: @entity3


abstract: OBJECTIVE: To evaluate the efficacy of a novel 2-stage treatment with reductive surgery plus percutaneous isolated hepatic perfusion (PIHP) for @entity3 ( @entity3 ), which was previously unresectable. SUMMARY BACKGROUND DATA: Surgical resection is the treatment of choice for @entity3 , but the majority of @entity0 with advanced @entity3 are not suitable candidates. PIHP is a minimally invasive surgery that allows high-dose regional chemotherapy of the liver, and our phase II studies have shown its profound efficacy for the local control of advanced @entity3 . METHODS: Twenty-five @entity0 with multiple advanced @entity3 were enrolled in this prospective study. In the first stage, all @entity0 underwent reductive hepatectomy: major hepatectomy in 13 @entity0 and segmentectomy or less in 12. In 2 @entity0 with subsegmentectomy, the retropancreatic and periportal metastatic lymph nodes were synchronously resected. Regardless of the type of hepatectomy, all @entity0 routinely underwent cholecystectomy, and ligations of the right gastric artery and arterial collaterals of the remnant liver to increase the safety and efficacy of PIHP. In the second stage, PIHP with @entity4 60-120 mg/m2/treatment was planned for a period of 1 to 3 months after surgery. RESULTS: Of 25 enrolled @entity0 , 22 successfully underwent PIHP an average of 1.8 times for the local control of residual @entity2 . In the remaining 3 @entity0 , PIHP was abandoned because 2 had rapid disease progression and 1 had @entity5 after surgery. In 22 @entity0 with the 2-stage treatment, 19 (86%) had objective @entity1 control (10 complete remissions and 9 partial responses with a median response duration of 16 months). The actuarial survival rate of all 25 @entity0 was 42% at 5 years. CONCLUSIONS: Reductive surgery plus PIHP produced a strong antitumoral effect on multiple advanced @entity3 , when liver function allows this concentrated treatment approach, and offers long-term survival in a subset of @entity0 who were previously deemed to have unresectable disease.

title: Reductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced XXXX .

answer: @entity3


abstract: OBJECTIVE: To analyze the features of pediatric @entity0 with recurrent @entity3 , identify the main ethiologic diagnoses and their clinical and laboratorial differences. @entity0 AND METHODS: We studied the medical records from 167 @entity0 attended at a pediatric gastroenterology outpatient clinic. After analysis of the entire sample, the @entity0 were divided in groups according to their diagnosis. Those @entity0 with more than one diagnosis were arranged into a subgroup named multiple diagnosis. Statistical analysis was performed with Kruskall-Wallis test for numeric variables and chi-square test for non-numeric variables. RESULTS: The @entity0 age ranged from 3 to 17 years (median 9), the number of consultations ranged from 1 to 16 (median 2) and the period of attendance ranged from 1 to 37 months (median 4). The @entity1 was mainly periumbilical (35.8%) and crampy-like (76.1%). The main diagnoses found were chronic intestinal constipation (58.6%), intestinal @entity4 (22.8%), and peptic disease (20.4%). In 34 @entity0 (20.3%) we were not able to establish the diagnosis. Among the groups, there was statistically significant difference in age (p=0.00003), number of consultations (p=0.00004), period of attendance (p=0.00001), kind of @entity1 (p=0.0003), intestinal habit (p=0.0002), stool features (p=0.0001), and evolution (p=0.0006). CONCLUSIONS: The authors conclude that finding @entity2 in @entity0 with recurrent @entity3 is much more common than it was expected. The pediatrician always has to consider the possibility of multifactorial origin for these @entity0 ' complaints.

title: [Recurrent XXXX at the Pediatric Gastroenterology Outpatient Clinic].

answer: @entity3


abstract: PURPOSE: This study assesses the relationship between students' confidence and competency in breast screening practices, compares different measurement approaches to these competencies, and assesses the effect on clinical breast examination (CBE) performance of an additional training session with a standardized @entity1 . METHOD: In the spring of 1998, 96 third-year medical students (47 @entity1 and 49 @entity1 ) at the University of Massachusetts Medical School completed knowledge items on @entity0 epidemiology and on perceived confidence in their counseling and CBE skills. The students were also rated on their performances of counseling and CBE skills. RESULTS: Higher levels of confidence in mammography counseling skills and higher interview skills scores were associated with higher mammography counseling scores. Confidence levels in performing CBE, however, were not related to the actual performances of CBE. Students' knowledge of @entity0 was modestly related to their CBE scores. Finally, the students with one extra training session with a standardized @entity1 performed significantly better on the CBE. CONCLUSIONS: It is important to directly measure students' @entity0 screening and physical examination skills because students' reported self-confidence for some skills might not accurately reflect their actual levels of performance. Additionally, while knowledge may be an important step to acquiring skills, knowledge may not be a good indicator of students' performances of risk assessment, counseling, or physical examination. Although confidence in counseling was related to counseling performance, the stability of this perception and how that translates into future cancer-control practices remain in question.

title: Assessing third-year medical students' XXXX .

answer: @entity0


abstract: OBJECTIVE: To investigate the intra-articular vascularisation of the synovial pannus in the knee of @entity0 with @entity2 ( @entity2 ) with power Doppler ultrasonography (PDS) and an echo contrast agent and correlate the area under the time-intensity curves with the clinical findings and laboratory measures of disease activity. METHOD: Forty two @entity0 with @entity2 (31 @entity0 , 11 @entity0 ) with history and signs of @entity4 , classified according to a modified index of @entity3 activity (active, moderately active, and inactive), were studied. Clinical and functional assessment (number of swollen joints, intensity of @entity1 , general health-visual analogue scale, disability index-Health Assessment Questionnaire, Ritchie articular index) and a laboratory evaluation were made on all @entity0 . Disease activity was evaluated using the disease activity score (DAS) and the @entity4 systemic index (CASI) for each @entity0 . All @entity0 were examined with conventional ultrasonography and PDS before injection of intravenous ultrasound contrast agent (Levovist). The quantitative estimation of the vascularisation of the synovial membrane was performed with time-intensity curves and calculation of the area under the curves. RESULTS: The mean (SD) value of the area underlying time-intensity curves was 216.2 (33.4) in @entity0 with active @entity3 , 186.8 (25.8) in @entity0 with moderately active @entity3 , and 169.6 (20.6) in those with inactive @entity3 . The mean value of the areas differed significantly between the @entity0 with active and those with inactive @entity3 (p<0.01). The mean value of the area under the curve of the entire group was weakly correlated with the number of swollen joints (p=0.038), but a strong correlation was found with composite indexes of disease activity such as the DAS (p=0.006) and CASI (p=0.01). No correlation was found with age, disease duration, and other laboratory and clinical variables. CONCLUSION: PDS may be a valuable tool to detect fractional vascular volume and to assist clinicians in distinguishing between inflammatory and non-inflammatory pannus. The transit of microbubbles of ultrasound contrast across a tissue can be used to estimate haemodynamic alterations and may have a role in assessing synovial activity and the therapeutic response to treatment of @entity3 of the knee joint.

title: Power Doppler sonography in the assessment of synovial tissue of the knee joint in XXXX : a preliminary experience.

answer: @entity2


abstract: PURPOSE: Galectin-3 is a pleiotropic @entity4 -binding protein participating in a variety of normal and pathologic processes, including @entity1 progression. This study was aimed at evaluating the prognostic value of galectin-3 expression in node-negative @entity3 (SCC). @entity0 AND METHODS: Galectin-3 expression was analyzed by immunohistochemistry using M3/38 monoclonal antibody, in a single-institution series of 73 node-negative laryngeal SCC @entity0 (median follow-up, 52 months; range, 2 to 90 months). RESULTS: Forty-two (57.5%) of 73 @entity0 expressed galectin-3. Galectin-3 expression was positively associated with @entity1 keratinization and histologic grade. A significant correlation was found between galectin-3 @entity1 positivity and longer relapse-free and overall survival. In univariate analysis, high-grade (grade 3 or 4) @entity1 , nonkeratinizing @entity1 , and galectin-3-negative @entity1 showed a significantly increased risk of relapse and @entity2 . In multivariate analysis, only galectin-3 expression retained an independent prognostic significance for both relapse-free and overall survival. CONCLUSION: We conclude that the absence of galectin-3 expression is an independent negative prognostic marker in laryngeal SCC @entity0 . Thus, histochemical detection of galectin-3 in these @entity1 could be useful for the selection of node-negative @entity0 with potentially unfavorable outcomes, to establish adjuvant therapy protocols.

title: Lack of expression of galectin-3 is associated with a poor outcome in node-negative @entity0 with XXXX .

answer: @entity3


abstract: PURPOSE: Galectin-3 is a pleiotropic @entity4 -binding protein participating in a variety of normal and pathologic processes, including @entity1 progression. This study was aimed at evaluating the prognostic value of galectin-3 expression in node-negative @entity3 (SCC). @entity0 AND METHODS: Galectin-3 expression was analyzed by immunohistochemistry using M3/38 monoclonal antibody, in a single-institution series of 73 node-negative laryngeal SCC @entity0 (median follow-up, 52 months; range, 2 to 90 months). RESULTS: Forty-two (57.5%) of 73 @entity0 expressed galectin-3. Galectin-3 expression was positively associated with @entity1 keratinization and histologic grade. A significant correlation was found between galectin-3 @entity1 positivity and longer relapse-free and overall survival. In univariate analysis, high-grade (grade 3 or 4) @entity1 , nonkeratinizing @entity1 , and galectin-3-negative @entity1 showed a significantly increased risk of relapse and @entity2 . In multivariate analysis, only galectin-3 expression retained an independent prognostic significance for both relapse-free and overall survival. CONCLUSION: We conclude that the absence of galectin-3 expression is an independent negative prognostic marker in laryngeal SCC @entity0 . Thus, histochemical detection of galectin-3 in these @entity1 could be useful for the selection of node-negative @entity0 with potentially unfavorable outcomes, to establish adjuvant therapy protocols.

title: Lack of expression of galectin-3 is associated with a poor outcome in node-negative XXXX with @entity3 .

answer: @entity0


abstract: @entity4 is a new antiarrhythmic drug approved for therapy of life-threatening @entity2 and @entity3 refractory to previous antiarrhythmic therapy. The drug is poorly absorbed and avidly binds to all adipose tissue within the body. As a result of its unique pharmacologic properties, a 1-2 month period of loading with a high dose is required before therapeutic and steady state tissue concentrations are achieved. Therefore, there is a delay in the onset of antiarrhythmic effects of the drug and evaluation of efficacy using either noninvasive or invasive techniques should be performed 1-2 months after the initiation of therapy. It has been reported that suppression of runs of @entity2 ( @entity2 ) documented on ambulatory monitor correlates with long-term efficacy. When invasive electrophysiologic (EP) studies are used, continued inducibility does not predict recurrence. Other important factors from the EP test include the rate of the induced @entity2 and prolongation of the refractory period. Another problem related to @entity4 's pharmacologic properties is the occurrence of side effects which generally develop after weeks to months of drug therapy. Moreover, the incidence of @entity1 increases over time. Although most side effects are unrelated to dose or blood level, it is possible that they correlate with the cumulative dose administered or total period of drug exposure. @entity4 causes side effects which involve many organ systems. Most side effects are minor and cause no or only minor symptoms. Serious side effects, primarily cardiac, pulmonary, neurologic and thyroid, occur in about 18% of @entity0 and often requires drug discontinuation. Therefore, use of @entity4 requires careful and continuous follow-up and monitoring for efficacy and @entity1 .

title: Practical follow-up guidelines for @entity0 treated with XXXX .

answer: @entity4


abstract: @entity4 is a new antiarrhythmic drug approved for therapy of life-threatening @entity2 and @entity3 refractory to previous antiarrhythmic therapy. The drug is poorly absorbed and avidly binds to all adipose tissue within the body. As a result of its unique pharmacologic properties, a 1-2 month period of loading with a high dose is required before therapeutic and steady state tissue concentrations are achieved. Therefore, there is a delay in the onset of antiarrhythmic effects of the drug and evaluation of efficacy using either noninvasive or invasive techniques should be performed 1-2 months after the initiation of therapy. It has been reported that suppression of runs of @entity2 ( @entity2 ) documented on ambulatory monitor correlates with long-term efficacy. When invasive electrophysiologic (EP) studies are used, continued inducibility does not predict recurrence. Other important factors from the EP test include the rate of the induced @entity2 and prolongation of the refractory period. Another problem related to @entity4 's pharmacologic properties is the occurrence of side effects which generally develop after weeks to months of drug therapy. Moreover, the incidence of @entity1 increases over time. Although most side effects are unrelated to dose or blood level, it is possible that they correlate with the cumulative dose administered or total period of drug exposure. @entity4 causes side effects which involve many organ systems. Most side effects are minor and cause no or only minor symptoms. Serious side effects, primarily cardiac, pulmonary, neurologic and thyroid, occur in about 18% of @entity0 and often requires drug discontinuation. Therefore, use of @entity4 requires careful and continuous follow-up and monitoring for efficacy and @entity1 .

title: Practical follow-up guidelines for XXXX treated with @entity4 .

answer: @entity0


abstract: The present review covers 208 papers dealing with determination of the metals @entity5 , @entity4 , lead and @entity2 in @entity0 biologic material. A comprehensive data bank survey of the literature from January 1980 to April 1984 was conducted and supplemented by review of some earlier publications. As shown by comparison of the results from a number of papers, the various state-of-the-art methods for determining metal content in biologic materials (e.g., atomic absorption spectrophotometry, neutron activation analysis, and x-ray fluorescent analysis) appear to be equally sensitive and reliable. These detection methods are suited to determination of the above metals in the following media: @entity5 in urine, hair; @entity4 in blood, urine, hair, renal cortex; lead in blood, hair; @entity2 in blood, urine, hair. To permit better comparison of the results presented in various publications, agreement must be reached on use of uniform concentration units and participation in quality control programs. Safe levels of chronic biological exposure overlap with concentrations which cause health effects or measurable impairment of body function over a wide range. Individual sensitivity to biological exposure varies. In a number of studies, metal concentrations are measured in symptom-free @entity0 which cause symptoms in @entity0 examined in other studies. Due to differences in the sensitivity of detection of symptoms, the range of minimum levels of biological exposure considered to be associated with deleterious health effects (levels of critical exposure) is unacceptably broad. Minimum levels of critical exposure should protect against development of early symptoms of @entity1 . If the lowest published critical levels of biological exposure are taken as a cutoff, then a sizable portion of the @entity0 currently revealing metal exposure in any of the reported media exceeds such levels. Symptoms of detrimental effects should be detectable in such @entity0 and should be investigated. In establishing and evaluating current minimum levels of critical chronic metal exposure, there is a general need for a quantitative increase in determinations and for a qualitative increase in the sensitivity of detection of symptoms and other health effects--in order to avoid @entity3 on reports of acute @entity1 . When detected levels of a given metal are in a range held to be normal, exclusion of toxic effects and poisoning requires additional consideration of clinical findings.

title: [A study of the literature on the concentrations of XXXX , lead, @entity4 and @entity2 in body fluids and tissues to define normal values and detection of overload. 1. Description of analytical methods and @entity5 ].

answer: @entity5


abstract: The present review covers 208 papers dealing with determination of the metals @entity5 , @entity4 , lead and @entity2 in @entity0 biologic material. A comprehensive data bank survey of the literature from January 1980 to April 1984 was conducted and supplemented by review of some earlier publications. As shown by comparison of the results from a number of papers, the various state-of-the-art methods for determining metal content in biologic materials (e.g., atomic absorption spectrophotometry, neutron activation analysis, and x-ray fluorescent analysis) appear to be equally sensitive and reliable. These detection methods are suited to determination of the above metals in the following media: @entity5 in urine, hair; @entity4 in blood, urine, hair, renal cortex; lead in blood, hair; @entity2 in blood, urine, hair. To permit better comparison of the results presented in various publications, agreement must be reached on use of uniform concentration units and participation in quality control programs. Safe levels of chronic biological exposure overlap with concentrations which cause health effects or measurable impairment of body function over a wide range. Individual sensitivity to biological exposure varies. In a number of studies, metal concentrations are measured in symptom-free @entity0 which cause symptoms in @entity0 examined in other studies. Due to differences in the sensitivity of detection of symptoms, the range of minimum levels of biological exposure considered to be associated with deleterious health effects (levels of critical exposure) is unacceptably broad. Minimum levels of critical exposure should protect against development of early symptoms of @entity1 . If the lowest published critical levels of biological exposure are taken as a cutoff, then a sizable portion of the @entity0 currently revealing metal exposure in any of the reported media exceeds such levels. Symptoms of detrimental effects should be detectable in such @entity0 and should be investigated. In establishing and evaluating current minimum levels of critical chronic metal exposure, there is a general need for a quantitative increase in determinations and for a qualitative increase in the sensitivity of detection of symptoms and other health effects--in order to avoid @entity3 on reports of acute @entity1 . When detected levels of a given metal are in a range held to be normal, exclusion of toxic effects and poisoning requires additional consideration of clinical findings.

title: [A study of the literature on the concentrations of @entity5 , lead, @entity4 and @entity2 in body fluids and tissues to define normal values and detection of overload. 1. Description of analytical methods and XXXX ].

answer: @entity5


abstract: The present review covers 208 papers dealing with determination of the metals @entity5 , @entity4 , lead and @entity2 in @entity0 biologic material. A comprehensive data bank survey of the literature from January 1980 to April 1984 was conducted and supplemented by review of some earlier publications. As shown by comparison of the results from a number of papers, the various state-of-the-art methods for determining metal content in biologic materials (e.g., atomic absorption spectrophotometry, neutron activation analysis, and x-ray fluorescent analysis) appear to be equally sensitive and reliable. These detection methods are suited to determination of the above metals in the following media: @entity5 in urine, hair; @entity4 in blood, urine, hair, renal cortex; lead in blood, hair; @entity2 in blood, urine, hair. To permit better comparison of the results presented in various publications, agreement must be reached on use of uniform concentration units and participation in quality control programs. Safe levels of chronic biological exposure overlap with concentrations which cause health effects or measurable impairment of body function over a wide range. Individual sensitivity to biological exposure varies. In a number of studies, metal concentrations are measured in symptom-free @entity0 which cause symptoms in @entity0 examined in other studies. Due to differences in the sensitivity of detection of symptoms, the range of minimum levels of biological exposure considered to be associated with deleterious health effects (levels of critical exposure) is unacceptably broad. Minimum levels of critical exposure should protect against development of early symptoms of @entity1 . If the lowest published critical levels of biological exposure are taken as a cutoff, then a sizable portion of the @entity0 currently revealing metal exposure in any of the reported media exceeds such levels. Symptoms of detrimental effects should be detectable in such @entity0 and should be investigated. In establishing and evaluating current minimum levels of critical chronic metal exposure, there is a general need for a quantitative increase in determinations and for a qualitative increase in the sensitivity of detection of symptoms and other health effects--in order to avoid @entity3 on reports of acute @entity1 . When detected levels of a given metal are in a range held to be normal, exclusion of toxic effects and poisoning requires additional consideration of clinical findings.

title: [A study of the literature on the concentrations of @entity5 , lead, @entity4 and XXXX in body fluids and tissues to define normal values and detection of overload. 1. Description of analytical methods and @entity5 ].

answer: @entity2


abstract: The present review covers 208 papers dealing with determination of the metals @entity5 , @entity4 , lead and @entity2 in @entity0 biologic material. A comprehensive data bank survey of the literature from January 1980 to April 1984 was conducted and supplemented by review of some earlier publications. As shown by comparison of the results from a number of papers, the various state-of-the-art methods for determining metal content in biologic materials (e.g., atomic absorption spectrophotometry, neutron activation analysis, and x-ray fluorescent analysis) appear to be equally sensitive and reliable. These detection methods are suited to determination of the above metals in the following media: @entity5 in urine, hair; @entity4 in blood, urine, hair, renal cortex; lead in blood, hair; @entity2 in blood, urine, hair. To permit better comparison of the results presented in various publications, agreement must be reached on use of uniform concentration units and participation in quality control programs. Safe levels of chronic biological exposure overlap with concentrations which cause health effects or measurable impairment of body function over a wide range. Individual sensitivity to biological exposure varies. In a number of studies, metal concentrations are measured in symptom-free @entity0 which cause symptoms in @entity0 examined in other studies. Due to differences in the sensitivity of detection of symptoms, the range of minimum levels of biological exposure considered to be associated with deleterious health effects (levels of critical exposure) is unacceptably broad. Minimum levels of critical exposure should protect against development of early symptoms of @entity1 . If the lowest published critical levels of biological exposure are taken as a cutoff, then a sizable portion of the @entity0 currently revealing metal exposure in any of the reported media exceeds such levels. Symptoms of detrimental effects should be detectable in such @entity0 and should be investigated. In establishing and evaluating current minimum levels of critical chronic metal exposure, there is a general need for a quantitative increase in determinations and for a qualitative increase in the sensitivity of detection of symptoms and other health effects--in order to avoid @entity3 on reports of acute @entity1 . When detected levels of a given metal are in a range held to be normal, exclusion of toxic effects and poisoning requires additional consideration of clinical findings.

title: [A study of the literature on the concentrations of @entity5 , lead, XXXX and @entity2 in body fluids and tissues to define normal values and detection of overload. 1. Description of analytical methods and @entity5 ].

answer: @entity4


abstract: Membrane deterioration in plant senescence is commonly associated with progressive decreases in membrane phospholipid content. This study investigated the expression and regulation of @entity1 ( @entity1 ; EC 3.1.4.4) during senescence in @entity3 ( @entity3 . cv Hale) leaf discs. The rate of leaf senescence was accelerated by 50 [mu]M @entity0 and was attenuated by 50 [mu]M cytokinin during incubation at 23[deg]C for up to 5 @entity5 senescence was indicated by decreases in the content of total proteins, chlorophyll, and phospholipids. @entity1 activity in both membrane-associated and cytosolic fractions showed a gradual increase in the absence of @entity6 . @entity0 stimulated an increase in membrane-associated @entity1 and had little effect on the soluble form. On the other hand, @entity4 retarded the increase in membrane-associated @entity1 . Immunoblotting analysis using @entity1 -specific antibodies revealed that the changes in @entity1 activity were correlated with those of @entity1 protein. Analysis of @entity1 by nondenaturing PAGE showed the appearance of a @entity1 structural variant, @entity1 3, in @entity0 -treated leaf discs. Northern blotting analysis using a @entity1 cDNA probe revealed an increase in @entity1 mRNA in senescing leaf discs. These data indicate complex mechanisms for the regulation of @entity1 during senescence, which include increases in membrane-associated @entity1 , differential expression of @entity1 isoforms, and changes in amounts of @entity1 protein and mRNA. Such controlled expression points to a role for @entity2 and plant senescence.

title: Expression of Phospholipase D during XXXX Leaf Senescence.

answer: @entity3


abstract: To establish an early reliable diagnostic test for @entity3 ( @entity3 ) type 1 @entity2 (HSVE), we used isoelectric focusing (IEF) and an IEF-overlay technique with radiolabeled @entity3 glycoprotein B (gB) to study 7 serum and 12 cerebrospinal fluid (CSF) samples from 12 @entity0 with presumed or biopsy-proved HSVE. Blood-brain barrier damage and increased intra-blood-brain barrier IgG synthesis were detected in 5 of the 7 @entity0 with HSVE. CSF oligoclonal bands were found in 6 of 11 @entity0 . Using an IEF-overlay technique, we detected anti-gB antibody in all serum (7 of 7) and in 10 of 12 CSF samples. Anti-gB antibody was found in 4 of 6 CSF specimens obtained within the first week of disease (days 3 to 5) and in all samples collected later in the disease. The pH range of anti-gB antibody activity was broad (4.5 to 9.5), indicating a heterogeneous immune response to @entity3 . A hematogenous origin of the CSF antibody was suggested because anti-gB antibody appeared in serum before matched CSF and because both serum and matched CSF had a similar antibody IEF pattern. Local production of anti-gB antibody was suggested in some cases because of a greater prominence of anti-gB antibody in CSF than in matched sera and because CSF oligoclonal bands had anti-gB antibody activity. In contrast, only one of 6 CSF samples from @entity0 with @entity1 had gB antibody activity; in this case, anti-gB antibody activity did not correspond in isoelectric point location to oligoclonal bands.(ABSTRACT TRUNCATED AT 250 WORDS)

title: An isoelectric focusing study in @entity3 XXXX .

answer: @entity2


abstract: To establish an early reliable diagnostic test for @entity3 ( @entity3 ) type 1 @entity2 (HSVE), we used isoelectric focusing (IEF) and an IEF-overlay technique with radiolabeled @entity3 glycoprotein B (gB) to study 7 serum and 12 cerebrospinal fluid (CSF) samples from 12 @entity0 with presumed or biopsy-proved HSVE. Blood-brain barrier damage and increased intra-blood-brain barrier IgG synthesis were detected in 5 of the 7 @entity0 with HSVE. CSF oligoclonal bands were found in 6 of 11 @entity0 . Using an IEF-overlay technique, we detected anti-gB antibody in all serum (7 of 7) and in 10 of 12 CSF samples. Anti-gB antibody was found in 4 of 6 CSF specimens obtained within the first week of disease (days 3 to 5) and in all samples collected later in the disease. The pH range of anti-gB antibody activity was broad (4.5 to 9.5), indicating a heterogeneous immune response to @entity3 . A hematogenous origin of the CSF antibody was suggested because anti-gB antibody appeared in serum before matched CSF and because both serum and matched CSF had a similar antibody IEF pattern. Local production of anti-gB antibody was suggested in some cases because of a greater prominence of anti-gB antibody in CSF than in matched sera and because CSF oligoclonal bands had anti-gB antibody activity. In contrast, only one of 6 CSF samples from @entity0 with @entity1 had gB antibody activity; in this case, anti-gB antibody activity did not correspond in isoelectric point location to oligoclonal bands.(ABSTRACT TRUNCATED AT 250 WORDS)

title: An isoelectric focusing study in XXXX @entity2 .

answer: @entity3


abstract: We present and compare the clinical features and outcomes of 12 @entity0 with primary @entity5 (ADS- @entity2 ) of the liver who underwent hepatic resection at our institution with those of 29 cases whose surgical treatment were reported in the literature. @entity4 ( @entity2 ) occurs @entity1 in most parts of the world. Reports of surgically treated cases of ADS- @entity2 are seen only sporadically because of the low resectability rate, difficulty in making an early diagnosis, and the poor prognosis. Furthermore, a clinicopathological study based on a certain number of surgically treated cases is still lacking. From 1977 to 2001, 12 cases of hepatic ADS- @entity2 who underwent hepatic resection were reviewed in respect to clinical features and long-term results. The clinical features and outcomes of the 29 @entity0 who underwent hepatic resection reported in the literature are also summarized for comparison. Of 228 surgically treated @entity2 @entity0 in our institute, 12 (5.3%) were ADS- @entity2 . A male predominance was observed in our study and in the reported cases. In our series, prominent body @entity3 and prominent relationship to hepatolithiasis were observed. The prognosis is dismal in @entity0 with ADS- @entity2 who undergo hepatic resection; however, there was no significant difference in overall survival between the ADS- @entity2 and @entity2 groups. In our series, the 1-, 2-, and 3-year survival rates of ADS- @entity2 and @entity2 @entity0 were 18.8%, 0%, and 0% and 32.8%, 14.8%, and 9.5%, respectively. ADS- @entity2 is prominently related to body @entity3 and hepatolithiasis in our series compared with the reported cases. The prognosis of @entity0 with ADS- @entity2 who undergo hepatic resection is dismal because of the specific biological behavior of ADS- @entity2 .

title: XXXX of the liver: clinicopathologic features in 12 @entity0 and review of the literature.

answer: @entity5


abstract: We present and compare the clinical features and outcomes of 12 @entity0 with primary @entity5 (ADS- @entity2 ) of the liver who underwent hepatic resection at our institution with those of 29 cases whose surgical treatment were reported in the literature. @entity4 ( @entity2 ) occurs @entity1 in most parts of the world. Reports of surgically treated cases of ADS- @entity2 are seen only sporadically because of the low resectability rate, difficulty in making an early diagnosis, and the poor prognosis. Furthermore, a clinicopathological study based on a certain number of surgically treated cases is still lacking. From 1977 to 2001, 12 cases of hepatic ADS- @entity2 who underwent hepatic resection were reviewed in respect to clinical features and long-term results. The clinical features and outcomes of the 29 @entity0 who underwent hepatic resection reported in the literature are also summarized for comparison. Of 228 surgically treated @entity2 @entity0 in our institute, 12 (5.3%) were ADS- @entity2 . A male predominance was observed in our study and in the reported cases. In our series, prominent body @entity3 and prominent relationship to hepatolithiasis were observed. The prognosis is dismal in @entity0 with ADS- @entity2 who undergo hepatic resection; however, there was no significant difference in overall survival between the ADS- @entity2 and @entity2 groups. In our series, the 1-, 2-, and 3-year survival rates of ADS- @entity2 and @entity2 @entity0 were 18.8%, 0%, and 0% and 32.8%, 14.8%, and 9.5%, respectively. ADS- @entity2 is prominently related to body @entity3 and hepatolithiasis in our series compared with the reported cases. The prognosis of @entity0 with ADS- @entity2 who undergo hepatic resection is dismal because of the specific biological behavior of ADS- @entity2 .

title: @entity5 of the liver: clinicopathologic features in 12 XXXX and review of the literature.

answer: @entity0


abstract: @entity8 is an @entity1 characterized by the failure of phagocytic cells to produce @entity2 upon the ingestion of microorganisms due to a lesion in a membrane-associated @entity5 -oxidase. The components of the oxidase have been incompletely characterized by standard biochemical approaches. A genetic strategy has recently led to the identification of the gene affected in the common @entity7 without reference to its protein product. The @entity6 gene, assigned to chromosome position Xp21.1, encodes a phagocyte-specific RNA transcript that is mutated in @entity0 with @entity6 . Antisera directed toward the predicted protein product of the @entity6 gene recognize a 90 kD membrane glycoprotein, which corresponds to the larger subunit of the phagocyte b-cytochrome heterodimer. The recent genetic and biochemical findings provide an explanation for the consistent absence of the b-cytochrome spectrum in @entity6 , and establish this cytochrome as an essential component of the phagocyte oxidase. The primary @entity4 sequence of both the 90 kD b-cytochrome subunit and the 22 kD subunit (cloned as the cDNA using a specific antisera) have no significant similarity to other proteins, including previously studied cytochromes. As both subunits of the b-cytochrome heterodimer are absent in @entity6 , despite a @entity1 of only the larger polypeptide, a close interaction between the two subunits may be important for b-cytochrome stability and function. Expression of the b-cytochrome large subunit mRNA is increased by @entity3 , an important macrophage activator. Partial or complete restoration of oxidase activity in some @entity6 @entity0 treated with @entity3 suggests new therapeutic approaches in the management of this disorder. Molecular reagents prepared from the cloned @entity6 cDNA or gene may prove to be clinically useful in prenatal diagnosis and may provide a basis for somatic gene therapy in future.

title: Molecular genetics of XXXX .

answer: @entity8


abstract: Drug resistance patterns of shigella strains were investigated in a prospective manner in Etimesgut district during a period of 1 year. Thirty strains shigella were isolated, belonged to three subgroups with preponderance of Sh. flexneri (70%), followed by Sh. sonnei (27%) and Sh. boydii (3%). The resistance was highest with @entity5 (80%), followed by @entity0 - @entity1 ( @entity4 - @entity7 ) (53%) and @entity3 (43%). Only three strains (10%) were sensitive to all eight antibiotics tested. Sixteen (53%) were resistant to three or more antibiotics. The data showed an increase in resistance to the commonly used antimicrobial agents--namely IMP- @entity7 and @entity3 . @entity8 - @entity7 is no longer the drug of choice in severe @entity6 , at least in this region of @entity2 .

title: [Shigella serotypes and drug resistance patterns of strains isolated in Etimesgut, XXXX , in 1987].

answer: @entity2


abstract: A self-completion questionnaire sent to 2600 Nottinghamshire members of the Graphical Paper and Media Union elicited a 62% response. Forty one per cent of respondents reported suffering a skin complaint at some time and 11% had a current skin problem on the hand. This paper reports the validation stage of the study. Samples of 45 'cases' of self-reported @entity3 and 60 'controls', who reported they had never suffered a skin complaint, were clinically examined. All 45 self-reported cases were clinically confirmed as @entity3 . Occupationally related @entity6 ( @entity6 ) was diagnosed in 20 (44%); 26 (58%) complaints were thought to be induced or exacerbated by occupation. Of the controls, 21 (35%) were also diagnosed with a skin complaint, the majority being mild, with an occupational association in 17, the majority (15) being @entity6 . Sixteen @entity6 cases were patch tested resulting in positive reactions to colophony, @entity5 , @entity4 and @entity7 (2 of each). Two cases of @entity2 on the face were also identified, of which the @entity0 were unaware. Although there was no false positive self-reporting there was a considerable number of false negatives, demonstrating the importance of clinical validation of questionnaires relating to @entity1 . This study has highlighted the need for improvement in skin care provision in the printing industry.

title: Clinical examinations to validate self-completion questionnaires: XXXX in the UK printing industry.

answer: @entity3


abstract: Although time has been recognized as a critical factor in the treatment of other @entity2 , it has been an underemphasized variable in the treatment of @entity1 . Animal models of @entity2 have demonstrated that neurologic recovery is more likely the shorter the duration of occlusion. Complete recovery does not occur if the occlusion persists more than six hours. Prior trials have only rarely begun treatment within six hours of @entity1 onset. Over the past five years, we have participated in three @entity1 trials and have tried to identify factors that lead to delays in treatment. Factors that affect the time from @entity1 onset to arrival at the hospital include recognition of @entity1 by the @entity0 , prehospital care personnel, and physicians. After arrival at the hospital, factors that can significantly delay treatment include the time to obtain computed tomography and the site of treatment (emergency department vs ICU). With proper attention, the time from @entity0 arrival until treatment should be less than one hour. Future efforts should be directed toward reducing the time from @entity1 onset until arrival at the hospital. Education of the public, high-risk @entity0 , prehospital care providers, and physicians may aid in these efforts.

title: Identification and entry of the XXXX with acute cerebral infarction.

answer: @entity0


abstract: The prevalence of arterial @entity1 , as defined by the W.H.O. (systolic BP greater than 160 mmHg and/or diastolic BP greater than 95 mmHg), and the prevalence of its treatment were studied in 2595 local government employees of Marseilles, aged from 20 to 65 years. The prevalence of @entity1 was 17.96 p. 100 (466/2595, including 222 @entity0 and 244 @entity0 ). The prevalence of normal tension was 57.50 p. 100 (1492/2595, including 802 @entity0 and 690 @entity0 ). The prevalence of treated @entity1 was 37.98 p. 100 (177/466) divided into 29.27 p. 100 (65/222) in @entity0 and 45.90 p. 100 (112/244) in @entity0 (p less than 0.0001). Blood pressure was controlled by treatment in 32.30 p. 100 (21/65) of treated @entity0 and in 36.61 p. 100 (41/112) of treated @entity0 ( @entity3 ). 81.14 p. 100 (198/244) of @entity1 @entity0 and 57/82 p. 100 (399/690) of normotensive @entity0 were active (managers, executives). In treated @entity0 , the plasma level of apoprotein A1 was decreased and that of apoprotein B was increased. Among @entity0 , the global score at Bortner questionnaire was significantly lower in the group of 175 untreated @entity1 @entity0 (176 +/- 46) than in the group of treated @entity1 @entity0 (192 +/- 48, p less than 0.05) and in the group of normotensive subjects (186 +/- 41, p less than 0.05). This indicated that untreated @entity1 @entity0 have a tendency to type B pattern and suggested a line of research aimed at a better understanding of the relative failure of anti- @entity1 treatments in the prevention of @entity2 .

title: [Prevalence of arterial XXXX and its treatment in 2,595 adults].

answer: @entity1


abstract: A retrospective analysis of peripheral and renal vein plasma @entity5 activity has been performed in 9 @entity0 with @entity8 (3 fibromuscular @entity6 and 7 @entity3 ). In all cases angiography showed a reduction of the arterial diameter of more than 70 p. 100. The renal artery was occluded in 3 cases. All @entity0 received a constant @entity7 diet (100 mEq/day). Peripheral PRA values were classified as normal or low in 6 cases (less than 2.8 ng/ml/h) and high in one case (greater than 2.8 ng/ml/h): this values concerned 2 cases with @entity1 and 1 case with a narrowing of 90 p. 100. Renal venous @entity5 ratio of 1.5 or more has been found in 8 cases. In one case, the @entity4 was quite symmetrical (70 p. 100) and the ratio less than 1.5. The secretion index has been calculated as the ratio between the venoarterial difference of both affected and unaffected side over the arterial value of PRA (V-A/A). On the more stenosed side, was found a V-A/A ratio of 0.5 or more. This ratio is particularly high in case of artery @entity2 , but there is no correlation between the ratio and the degree of @entity4 . On the contralateral side, where the lesions were less important, the V-A/A ratio was low, ranging from 0 to 0.2; this estimation of @entity5 secretion was found despite a significant @entity4 on the angiography. 7 @entity0 underwent PTA or surgery. 2 kidneys with arterial @entity2 were nephrectomized. In 5 cases the surgical treatment is performed on the 2 sides during the same procedure.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Lateralization of XXXX secretion in renovascular hypertension with bilateral @entity8 ].

answer: @entity5