abstract: BACKGROUND: You-Gui pills (You-Gui-Wan; YGW) can promote T lymphocyte proliferation and differentiation, and restore @entity6 / @entity4 balance in the treatment of @entity5 , but their mechanism of action is not fully known. This study aims to explore whether YGW can induce histone deacetylation or acetylation in memory T lymphocytes (Tm) for improvement of airway @entity1 in @entity5 . METHODS: CD4(+)CD45RB(low) cells, as Tm, were obtained by magnetic-activated cell sorting and flow cytometry from the spleens of BALB/c @entity0 with ovalbumin (OVA)-induced @entity5 . Tm were cocultured with @entity7 (CORT; 1000 nM), serum containing low (0.225  g/kg), moderate (0.9  g/kg), or high (3.6  g/kg) doses of YGW, or medium only, and then adoptively transferred into na  ve @entity0 (n   =   5 per group). Recipient @entity0 were challenged with aerosolized OVA. The levels of @entity2 , @entity3 , @entity8 , and IFN-y in culture supernatants and bronchoalveolar lavage fluid (BALF) from the OVA-challenged @entity0 were measured by ELISA. Histone deacetylase (HDAC) and @entity12 ( @entity12 ) activities and protein expressions of @entity10 , @entity11 , and @entity9 -11 in lung tissue were measured by western blotting analyses. The alveolar eosinophilic @entity1 index (AEII) was evaluated in the lungs of adoptive transfer recipient @entity0 . RESULTS: YGW reduced @entity1 and eosinophil infiltration into the lung tissues as evidenced by histology, with similar effects to those of CORT. High-, moderate-, and low-YGW increased HDAC (P   <   0.0001, P   =   0.0009 and P   =   0.0253 respectively) and decreased @entity12 (P   =   0.0001, P   =   0.0000 and P   =   0.0039, respectively) activities in dose-dependent manners in the lung tissues of adoptive transfer recipient @entity0 . Increased histone deacetylation of Tm by YGW reduced the AEII by reducing @entity11 (P   =   0.014), @entity2 (P   =   0.0004), @entity3 (P   =   0.0067), and @entity8 (P   =   0.0002), and inducing IFN-y release (P   =   0.0375). Moreover, YGW reduced inflammatory cytokines such as @entity2 , @entity3 , and @entity8 by upregulating the activities of @entity14 (P   =   0.003)/10 (P   =   0.003), @entity13 (P   <   0.0001), and @entity15 -11 (P   <   0.0001, P   <   0.0001 and P   <   0.0001, respectively), respectively, and increased IFN-y release by increasing @entity15 (P   <   0.0001). CONCLUSIONS: Histone deacetylation of Tm was observed during alleviation of allergen-induced @entity1 in @entity5 by YGW.

title: Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced XXXX in @entity5 .

answer: @entity1


abstract: BACKGROUND: You-Gui pills (You-Gui-Wan; YGW) can promote T lymphocyte proliferation and differentiation, and restore @entity6 / @entity4 balance in the treatment of @entity5 , but their mechanism of action is not fully known. This study aims to explore whether YGW can induce histone deacetylation or acetylation in memory T lymphocytes (Tm) for improvement of airway @entity1 in @entity5 . METHODS: CD4(+)CD45RB(low) cells, as Tm, were obtained by magnetic-activated cell sorting and flow cytometry from the spleens of BALB/c @entity0 with ovalbumin (OVA)-induced @entity5 . Tm were cocultured with @entity7 (CORT; 1000 nM), serum containing low (0.225  g/kg), moderate (0.9  g/kg), or high (3.6  g/kg) doses of YGW, or medium only, and then adoptively transferred into na  ve @entity0 (n   =   5 per group). Recipient @entity0 were challenged with aerosolized OVA. The levels of @entity2 , @entity3 , @entity8 , and IFN-y in culture supernatants and bronchoalveolar lavage fluid (BALF) from the OVA-challenged @entity0 were measured by ELISA. Histone deacetylase (HDAC) and @entity12 ( @entity12 ) activities and protein expressions of @entity10 , @entity11 , and @entity9 -11 in lung tissue were measured by western blotting analyses. The alveolar eosinophilic @entity1 index (AEII) was evaluated in the lungs of adoptive transfer recipient @entity0 . RESULTS: YGW reduced @entity1 and eosinophil infiltration into the lung tissues as evidenced by histology, with similar effects to those of CORT. High-, moderate-, and low-YGW increased HDAC (P   <   0.0001, P   =   0.0009 and P   =   0.0253 respectively) and decreased @entity12 (P   =   0.0001, P   =   0.0000 and P   =   0.0039, respectively) activities in dose-dependent manners in the lung tissues of adoptive transfer recipient @entity0 . Increased histone deacetylation of Tm by YGW reduced the AEII by reducing @entity11 (P   =   0.014), @entity2 (P   =   0.0004), @entity3 (P   =   0.0067), and @entity8 (P   =   0.0002), and inducing IFN-y release (P   =   0.0375). Moreover, YGW reduced inflammatory cytokines such as @entity2 , @entity3 , and @entity8 by upregulating the activities of @entity14 (P   =   0.003)/10 (P   =   0.003), @entity13 (P   <   0.0001), and @entity15 -11 (P   <   0.0001, P   <   0.0001 and P   <   0.0001, respectively), respectively, and increased IFN-y release by increasing @entity15 (P   <   0.0001). CONCLUSIONS: Histone deacetylation of Tm was observed during alleviation of allergen-induced @entity1 in @entity5 by YGW.

title: Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced @entity1 in XXXX .

answer: @entity5


abstract: UNASSIGNED: Risk stratification of @entity5 ( @entity6 ) is clinically important because such @entity0 are at high risk of @entity2 . Although reactive @entity1 species (ROS) are reported to be closely associated with the pathophysiology of @entity6 , there are few useful ROS biomarkers known for @entity6 @entity0 . Hence, our objectives in this study were to investigate whether serum derivatives of reactive @entity1 metabolites (DROM), a novel biomarker of ROS, is involved in the pathophysiology of @entity6 (case-control study), and is a significant predictor of future @entity2 in @entity6 @entity0 (follow-up study). @entity0 with suspected @entity3 ( @entity3 ) were enrolled and underwent coronary angiography. @entity0 with @entity6 (estimated glomerular filtration ratio <60mL/min/1.73mand/or @entity4 , n=324) were compared with those without @entity6 ( @entity6 ). Serum DROM was measured at stable conditions. A case-control study of the 324 @entity6 @entity0 and 263 @entity6 @entity0 was conducted after matching risk factors, and a follow-up study of the 324 @entity6 @entity0 was performed. @entity6 @entity0 were divided into low- and high-DROM groups using their median value (348 unit; called the Carratelli unit [U. @entity7 ]), and followed until the occurrence of @entity2 .DROM levels were significantly higher in risk factors-matched @entity6 @entity0 than in risk factors-matched @entity6 @entity0 (347.0 [301.8-391.8] U. @entity7 vs. 338.5 [299.8-384.3] U. @entity7 , P=0.03). During mean 23  14 months follow-up of 324 @entity6 @entity0 , 83 @entity2 were recorded. Kaplan-Meier analysis demonstrated a higher probability of @entity2 in @entity6 @entity0 with high DROM than in those with low DROM (P<0.001, log-rank test). Multivariate Cox hazard analysis including significant predictors in simple Cox hazard analysis demonstrated that high DROM was a significant and independent predictor of @entity2 in @entity6 @entity0 (hazard ratio: 1.76, 95% confidence interval: 1.10-2.82, P=0.02).In conclusion, serum DROM values were significant and independent predictors of @entity2 in @entity6 @entity0 , indicating that the measurements of DROM might provide clinical benefits for risk stratification of @entity6 @entity0 .

title: The Pivotal Role of a Novel Biomarker of Reactive XXXX Species in @entity5 .

answer: @entity1


abstract: UNASSIGNED: Risk stratification of @entity5 ( @entity6 ) is clinically important because such @entity0 are at high risk of @entity2 . Although reactive @entity1 species (ROS) are reported to be closely associated with the pathophysiology of @entity6 , there are few useful ROS biomarkers known for @entity6 @entity0 . Hence, our objectives in this study were to investigate whether serum derivatives of reactive @entity1 metabolites (DROM), a novel biomarker of ROS, is involved in the pathophysiology of @entity6 (case-control study), and is a significant predictor of future @entity2 in @entity6 @entity0 (follow-up study). @entity0 with suspected @entity3 ( @entity3 ) were enrolled and underwent coronary angiography. @entity0 with @entity6 (estimated glomerular filtration ratio <60mL/min/1.73mand/or @entity4 , n=324) were compared with those without @entity6 ( @entity6 ). Serum DROM was measured at stable conditions. A case-control study of the 324 @entity6 @entity0 and 263 @entity6 @entity0 was conducted after matching risk factors, and a follow-up study of the 324 @entity6 @entity0 was performed. @entity6 @entity0 were divided into low- and high-DROM groups using their median value (348 unit; called the Carratelli unit [U. @entity7 ]), and followed until the occurrence of @entity2 .DROM levels were significantly higher in risk factors-matched @entity6 @entity0 than in risk factors-matched @entity6 @entity0 (347.0 [301.8-391.8] U. @entity7 vs. 338.5 [299.8-384.3] U. @entity7 , P=0.03). During mean 23  14 months follow-up of 324 @entity6 @entity0 , 83 @entity2 were recorded. Kaplan-Meier analysis demonstrated a higher probability of @entity2 in @entity6 @entity0 with high DROM than in those with low DROM (P<0.001, log-rank test). Multivariate Cox hazard analysis including significant predictors in simple Cox hazard analysis demonstrated that high DROM was a significant and independent predictor of @entity2 in @entity6 @entity0 (hazard ratio: 1.76, 95% confidence interval: 1.10-2.82, P=0.02).In conclusion, serum DROM values were significant and independent predictors of @entity2 in @entity6 @entity0 , indicating that the measurements of DROM might provide clinical benefits for risk stratification of @entity6 @entity0 .

title: The Pivotal Role of a Novel Biomarker of Reactive @entity1 Species in XXXX .

answer: @entity5


abstract: UNASSIGNED: Statin intake has been reported to reduce the risk of several @entity1 beyond its @entity3 -lowering effects. However, little is known regarding the survival benefit of statins for @entity0 with @entity2 ( @entity2 ).We conducted a systematic literature search of multiple databases for studies published before November 2014, which investigated associations between statin intake and @entity2 prognosis. Meta-analysis was performed using random-effects model. The primary outcomes of interest were @entity5 ( @entity5 ) and @entity1 -specific mortality (CSM).Ten studies involving 76,851 @entity0 were eligible for this meta-analysis, with 7 studies investigating prediagnosis statin use and 5 studies reporting postdiagnosis statin use. Prediagnosis statin use was associated with reduced @entity5 (hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.61-0.88, P=0.001) and CSM (HR 0.80, 95% CI 0.77-0.84, P<0.001) for @entity0 with @entity2 . This effect persisted when stratified by @entity1 site and in studies adjusted by nonsteroidal anti-inflammatory drug use. In addition, postdiagnosis statin use was associated with decreased CSM (HR 0.70, 95% CI 0.60-0.82, P<0.001). However, we did not note reduced @entity5 for postdiagnosis statin use (HR 0.93, 95% CI 0.68-1.27, P=0.639). There appeared to be an association between postdiagnosis statin use and increased @entity5 in @entity4 -mutated @entity2 .Our findings provide evidence that prediagnosis statin therapy was associated with reduced @entity5 and CSM in @entity2 @entity0 ; postdiagnosis statin therapy indicated decreased CSM. However, findings may not apply to @entity0 with postdiagnosis statin therapy for @entity5 . Further studies are warranted to determine the relation between statin dose and duration on @entity2 survival.

title: Prognostic Significance of Statin Use in XXXX : A Systematic Review and Meta-Analysis.

answer: @entity2


abstract: PURPOSE: To examine the effects of the oil mixes (  -9,   -6 and   -3) in @entity0 subjected to thermal burn. It was also aimed to assess whether the sources of   3 would interfere with the effect of such mixes on the @entity1 . METHODS: Thirty-six @entity0 distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + @entity4 + @entity3 of fish) and burned + oil mix 3 (ALA + @entity3 from seaweed). The @entity1 was involving total thickness of skin. After the burns animals received the oil mixes for seven days. The lesions were evaluated by immunohistochemistry. RESULTS: Animals receiving mix 3 showed a smaller extension of the @entity1 as compared to those that were supplemented with other oils mixes. Expression of Ki-67 in the receiving Mix 3 increased as compared to all the other groups. Animals supplemented with mix 3 were able to inhibit @entity2 in injured tissue. CONCLUSION: @entity0 received oil mix in which the source of   3 (ALA+ @entity3 of seaweed) showed inhibition of @entity2 , increase in cell proliferation, and reduction the extension of thermal lesion.

title: Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating XXXX and Ki-67.

answer: @entity2


abstract: CONTEXT: @entity1 ( @entity1 ) is a bone assessment tool that offers information beyond that afforded by dual-energy x-ray absorptiometry (DXA) @entity1 ( @entity1 ) measurements. Adolescents with @entity5 ( @entity5 ) are known to exhibit compromised bone density and skeletal strength. OBJECTIVES: This study aimed to determine @entity1 among adolescents with @entity5 and evaluate the correlation with anthropometric, clinical and densitometric variables. DESIGN: Areal @entity1 spinal measures were analyzed for @entity1 . Findings were compared with clinical (height, weight, body mass index [BMI], age, pubertal development, @entity7 ) and self-reported data (illness duration, @entity6 , exercise, @entity3 , family history of @entity2 , and antidepressant use), and @entity1 measures by DXA and peripheral quantitative computed tomography (pQCT). SETTING AND @entity0 : This was an urban adolescent program consisting of 57 females with @entity5 , age 11-18 y. INTERVENTIONS: Interventions included DXA (absolute @entity1 and Z-score), pQCT (volumetric @entity1 [vBMD] and stress-strain index [SSI]), laboratory evaluation, and questionnaire administration. MAIN OUTCOME MEASURES: Main outcome measures included @entity1 , areal and vBMD, SSI, @entity3 history, disease duration. RESULTS: The @entity1 of six @entity0 (11%) showed degraded and 19 (33%) partially degraded microarchitecture. Spinal @entity1 was correlated (P < .05) with age, height, weight, BMI, pubertal stage, @entity1 , and body composition by DXA, and @entity1 and SSI by pQCT. @entity1 was not correlated with disease duration, @entity3 , @entity4 status, race, or ethnicity, and self-reported health data. CONCLUSIONS: @entity1 showed evidence of degraded microarchitecture in over 40% of this study sample, and strongly correlated with anthropometric data and measures of @entity1 and skeletal strength. @entity1 is a novel tool that captures another dimension of bone health in adolescents with @entity5 .

title: Spinal Bone Texture Assessed by Trabecular Bone Score in Adolescent @entity0 With XXXX .

answer: @entity5


abstract: CONTEXT: @entity1 ( @entity1 ) is a bone assessment tool that offers information beyond that afforded by dual-energy x-ray absorptiometry (DXA) @entity1 ( @entity1 ) measurements. Adolescents with @entity5 ( @entity5 ) are known to exhibit compromised bone density and skeletal strength. OBJECTIVES: This study aimed to determine @entity1 among adolescents with @entity5 and evaluate the correlation with anthropometric, clinical and densitometric variables. DESIGN: Areal @entity1 spinal measures were analyzed for @entity1 . Findings were compared with clinical (height, weight, body mass index [BMI], age, pubertal development, @entity7 ) and self-reported data (illness duration, @entity6 , exercise, @entity3 , family history of @entity2 , and antidepressant use), and @entity1 measures by DXA and peripheral quantitative computed tomography (pQCT). SETTING AND @entity0 : This was an urban adolescent program consisting of 57 females with @entity5 , age 11-18 y. INTERVENTIONS: Interventions included DXA (absolute @entity1 and Z-score), pQCT (volumetric @entity1 [vBMD] and stress-strain index [SSI]), laboratory evaluation, and questionnaire administration. MAIN OUTCOME MEASURES: Main outcome measures included @entity1 , areal and vBMD, SSI, @entity3 history, disease duration. RESULTS: The @entity1 of six @entity0 (11%) showed degraded and 19 (33%) partially degraded microarchitecture. Spinal @entity1 was correlated (P < .05) with age, height, weight, BMI, pubertal stage, @entity1 , and body composition by DXA, and @entity1 and SSI by pQCT. @entity1 was not correlated with disease duration, @entity3 , @entity4 status, race, or ethnicity, and self-reported health data. CONCLUSIONS: @entity1 showed evidence of degraded microarchitecture in over 40% of this study sample, and strongly correlated with anthropometric data and measures of @entity1 and skeletal strength. @entity1 is a novel tool that captures another dimension of bone health in adolescents with @entity5 .

title: Spinal Bone Texture Assessed by Trabecular Bone Score in Adolescent XXXX With @entity5 .

answer: @entity0


abstract: BACKGROUND AND AIM: This retrospective cohort study compared clinical outcomes and quality of life after peroral endoscopic myotomy (POEM) against laparoscopic Heller myotomy (LHM) for treatment of @entity5 . METHODS: @entity0 demographics, operation time, intraoperative @entity2 , hospital stay, time to resume diet and analgesic requirement were recorded. Clinical outcomes including recurrence of @entity4 , need for reintervention, and occurrence of @entity3 ( @entity3 ) were recorded. RESULTS: From 2001 to 2014, 33 @entity0 underwent POEM whereas 23 @entity0 received LHM. @entity0 LHM had with longer mean operative time (P   =   0.02), more @entity2 (P   =   0.001) and higher requirement for analgesics (P   =   0.009) than those treated by POEM. Hospital stay and time to resume diet were similar. Both POEM and LHM achieved similar @entity4 scores at postoperative 4 weeks, 3 months and 6 months. Twenty-six percent of LHM @entity0 and 15.2% of POEM @entity0 sustained @entity3 ( @entity3 ) after treatment (P   =   0.311). Six @entity0 required regular proton pump inhibitor three after POEM and three after LHM (P   =   0.639). Thirteen percent of LHM @entity0 sustained recurrent @entity4 and one required reintervention. There was no recurrence in the POEM group. Follow-up duration (mean [SD]) for the LHM group was significantly longer (60 [42] months vs 6 [4] months; P   =   0.001). There was also no difference in all four aspects of @entity3 -related quality of life outcomes. CONCLUSION: Compared to LHM, POEM achieved shorter operative time, less @entity2 and @entity1 . POEM is comparable to LHM for treatment of @entity5 with similar incidence of @entity3 after the procedure.

title: Comparison of early outcomes and quality of life after laparoscopic Heller's cardiomyotomy to peroral endoscopic myotomy for treatment of XXXX .

answer: @entity5


abstract: PURPOSE: The purpose of this study was to describe the technique and clinical results following the utilization of biomechanical and biological means for adequate @entity2 healing in management of non-union of the neck of femur while preventing distortion of normal hip biomechanics. METHODS: Twenty-two @entity0 with non-united fractures of @entity3 in adults were treated with what was termed the 'triple attack' procedure. This constituted iliac autogenous bone grafting, @entity1 together with static fixation across the non-union @entity2 site of the neck to avoid delayed @entity3 shortening. RESULTS: All @entity0 were classified as Pauwel's @entity2 . The mean time interval between the last operation and the current procedure was 4.6  months. Average operative time was 58.6  minutes. @entity0 were followed up for an average of 43.6  months. Complete union was achieved in all cases at an average of 4.3  months. Significant improvement of all radiological parameters was noticed together with the Harris hip score from an average of 21.2 pre-operatively to 89.6 at the last follow-up. CONCLUSION: The present study provides encouraging clinical and functional results to suggest that this newly described procedure ('triple attack') might be a valuable option in the management of non-united @entity3 .

title: Triple attack technique for non-union of XXXX .

answer: @entity3


abstract: @entity15 , small cell variant (T-PLL-s), is a rare @entity5 associated with a poor prognosis. We encountered a case of T-PLL-s with a characteristic phenotype. A 67-year-old female was referred to our hospital because of lymphocytosis in August 2013. @entity6 , @entity11 , and @entity1 were absent. Hematologic examination revealed a white blood cell count of 17.9 * 10(9)/L with 81.2% mature lymphocytes, which were small with a high nuclear/cytoplasmic ratio, lacking a nucleolus and cytoplasmic granules. @entity4 and @entity7 were not observed. Flow cytometric analysis showed that these lymphocytes were positive for @entity10 , cyCD3, @entity2 , @entity14 , @entity12 , @entity16 , and @entity9 (partially), but negative for smCD3, smTCR-ab and -y  , cyTCR-b, @entity13 , @entity3 , @entity8 , HLA-DR, and terminal deoxynucleotidyl transferase. Polymerase-chain reaction analysis of cells from both the peripheral blood and the bone marrow demonstrated monoclonal rearrangement of TCR-y. A possible rearranged band of the @entity17 gene was observed by Southern blot analysis. The karyotype of the marrow cells was 46, XX. A diagnosis of T-PLL-s, possibly at the stage of cytoplasmic CD3 expression in the ontogenesis of T-cells, was made. The @entity0 has been asymptomatic, and the white blood cell count has gradually increased during one-year observation, being 69.0 * 10(9)/L with 89.7% lymphocytes in August 2014.

title: XXXX , Small Cell Variant, Possibly at the Stage of Intracytoplasmic Expression of CD3 in T-Cell Ontogenesis.

answer: @entity15


abstract: BACKGROUND AND PURPOSE: The complexity of endovascular revascularization treatment (ERT) in acute @entity2 and the small number of @entity0 eligible for treatment justify the development of @entity1 center networks with interhospital @entity0 transfers. However, this approach might result in futile transfers (ie, the transfer of @entity0 who ultimately do not undergo ERT). Our aim was to analyze the frequency of these futile transfers and the reasons for discarding ERT and to identify the possible associated factors. METHODS: We analyzed an observational prospective ERT registry from a @entity1 collaboration ERT network consisting of 3 hospitals. There were interhospital transfers from the first attending hospital to the on-call ERT center for the @entity0 for whom this therapy was indicated, either primarily or after intravenous thrombolysis (drip and shift). RESULTS: The ERT protocol was activated for 199 @entity0 , 129 of whom underwent ERT (64.8%). A total of 120 (60.3%) @entity0 required a hospital transfer, 50 of whom (41%) ultimately did not undergo ERT. There were no differences in their baseline characteristics, the times from @entity1 onset, or in the delays in interhospital transfers between the transferred @entity0 who were treated and those who were not treated. The main reasons for rejecting ERT after the interhospital transfer were clinical improvement/arterial recanalization (48%) and neuroimaging criteria (32%). CONCLUSIONS: Forty-one percent of the ERT transfers were futile, but none of the baseline @entity0 characteristics predicted this result. Futility could be reduced if repetition of unnecessary diagnostic tests was avoided.

title: Futile Interhospital Transfer for Endovascular Treatment in Acute @entity2 : The XXXX Network Experience.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: The complexity of endovascular revascularization treatment (ERT) in acute @entity2 and the small number of @entity0 eligible for treatment justify the development of @entity1 center networks with interhospital @entity0 transfers. However, this approach might result in futile transfers (ie, the transfer of @entity0 who ultimately do not undergo ERT). Our aim was to analyze the frequency of these futile transfers and the reasons for discarding ERT and to identify the possible associated factors. METHODS: We analyzed an observational prospective ERT registry from a @entity1 collaboration ERT network consisting of 3 hospitals. There were interhospital transfers from the first attending hospital to the on-call ERT center for the @entity0 for whom this therapy was indicated, either primarily or after intravenous thrombolysis (drip and shift). RESULTS: The ERT protocol was activated for 199 @entity0 , 129 of whom underwent ERT (64.8%). A total of 120 (60.3%) @entity0 required a hospital transfer, 50 of whom (41%) ultimately did not undergo ERT. There were no differences in their baseline characteristics, the times from @entity1 onset, or in the delays in interhospital transfers between the transferred @entity0 who were treated and those who were not treated. The main reasons for rejecting ERT after the interhospital transfer were clinical improvement/arterial recanalization (48%) and neuroimaging criteria (32%). CONCLUSIONS: Forty-one percent of the ERT transfers were futile, but none of the baseline @entity0 characteristics predicted this result. Futility could be reduced if repetition of unnecessary diagnostic tests was avoided.

title: Futile Interhospital Transfer for Endovascular Treatment in Acute XXXX : The @entity1 Network Experience.

answer: @entity2


abstract: Eosinophilic @entity4 with @entity4 (EGPA) can affect @entity0 of childbearing age. However, reports of the disease in the postpartum period are limited. We present a case of postpartum-onset EGPA that went into clinical remission before relapsing in the subsequent postpartum period. Our @entity0 presented with dyspnoea, @entity6 and @entity3 , shown to be @entity2 , 3   days following the birth of her second @entity0 . CT of the thorax showed alveolar shadowing and mediastinal @entity5 . She was treated successfully for EGPA with glucocorticoid therapy. She declined maintenance treatment during remission. Off treatment, she remained disease free throughout her next pregnancy. In the postpartum period she relapsed in an almost identical manner, requiring prolonged glucocorticoid therapy, @entity1 and rituximab. This case highlights the importance of maintenance therapy around pregnancy in individuals with EGPA, and the need for careful monitoring of @entity0 with a history of EGPA in the postpartum period.

title: Postpartum onset and subsequent relapse of eosinophilic granulomatosis with XXXX .

answer: @entity4


abstract: INTRODUCTION: Conventional knowledge holds that the majority of @entity3 causing @entity2 ( @entity2 ) are found in moderate stenoses that produce < 50% loss of arterial diameter. This study aimed to analyse the culprit lesions in @entity0 who presented with @entity2 and underwent primary percutaneous coronary intervention (PPCI) at our institution. METHODS: @entity0 who underwent PPCI between June 2008 and August 2010 at our institution were included in the analysis. Quantitative coronary angiography was performed for the culprit lesions immediately after antegrade flow was restored by thrombectomy, low-profile balloon predilatation or guidewire crossing. RESULTS: A total of 1,021 @entity0 were included in the study. The mean age was 57    12 years and 85.2% were male. Lesion measurement was done after coronary flow was restored by thrombectomy (73.1%), @entity1 (24.1%) and following guidewire passage across the lesion (2.8%). Mean minimal luminal diameter was 1.1    0.5 mm, mean reference vessel diameter was 2.8    0.6 mm, mean diameter stenosis was 61    16% and mean lesion length was 16    6 mm. Most (80.2%) of the culprit lesions had diameter stenoses > 50% (p < 0.01). Although balloon angioplasty was performed in 24.1% of the @entity0 , the majority (64.2%) still had diameter stenoses > 50%. High-grade stenoses (> 50%) were more frequently observed in male @entity0 (p = 0.04). CONCLUSION: Contrary to the existing paradigm, we found that most of the @entity0 with @entity2 in our institution had culprit lesions with diameter stenosis > 50%.

title: High-grade culprit lesions are a common cause of XXXX .

answer: @entity2


abstract: OBJECTIVES: Reflecting on the self and on others activates specific brain areas and contributes to metacognition and social cognition. The aim of the current study is to investigate brain activation during self- and other-reflection in @entity0 with @entity2 ( @entity2 ). In addition, we examined whether potential abnormal brain activation in @entity2 @entity0 could distinguish @entity2 from @entity0 with @entity1 ( @entity1 ). METHODS: During functional magnetic resonance imaging (fMRI), 17 @entity2 @entity0 , 17 @entity1 @entity0 and 21 healthy controls (HCs) performed a self-reflection task. The task consisted of sentences divided into three conditions: self-reflection, other-reflection and semantic control. RESULTS: @entity2 @entity0 showed less activation in the posterior cingulate cortex (PCC) extending to the precuneus during other-reflection compared to HCs (p  =  0.028 FWE corrected on cluster-level within the regions of interest). In @entity1 @entity0 , the level of activation in this area was in between @entity2 @entity0 and HCs, with no significant differences between @entity0 with @entity1 and @entity2 . There were no group differences in brain activation during self-reflection. Moreover, there was a positive correlation between the PCC/precuneus activation during other-reflection and cognitive insight in @entity1 @entity0 , but not in @entity2 @entity0 . CONCLUSIONS: @entity2 @entity0 showed less activation in the PCC/precuneus during other-reflection. This may support an account of @entity3 (evaluation of past and current other-related information) in @entity2 @entity0 . Correlation differences of the PCC/precuneus activation with the cognitive insight in @entity0 with @entity2 and @entity1 might reflect an important difference between these disorders, which may help to further explore potentially distinguishing markers.

title: Brain activation during self- and other-reflection in XXXX with a history of psychosis: Comparison to @entity1 .

answer: @entity2


abstract: OBJECTIVES: Reflecting on the self and on others activates specific brain areas and contributes to metacognition and social cognition. The aim of the current study is to investigate brain activation during self- and other-reflection in @entity0 with @entity2 ( @entity2 ). In addition, we examined whether potential abnormal brain activation in @entity2 @entity0 could distinguish @entity2 from @entity0 with @entity1 ( @entity1 ). METHODS: During functional magnetic resonance imaging (fMRI), 17 @entity2 @entity0 , 17 @entity1 @entity0 and 21 healthy controls (HCs) performed a self-reflection task. The task consisted of sentences divided into three conditions: self-reflection, other-reflection and semantic control. RESULTS: @entity2 @entity0 showed less activation in the posterior cingulate cortex (PCC) extending to the precuneus during other-reflection compared to HCs (p  =  0.028 FWE corrected on cluster-level within the regions of interest). In @entity1 @entity0 , the level of activation in this area was in between @entity2 @entity0 and HCs, with no significant differences between @entity0 with @entity1 and @entity2 . There were no group differences in brain activation during self-reflection. Moreover, there was a positive correlation between the PCC/precuneus activation during other-reflection and cognitive insight in @entity1 @entity0 , but not in @entity2 @entity0 . CONCLUSIONS: @entity2 @entity0 showed less activation in the PCC/precuneus during other-reflection. This may support an account of @entity3 (evaluation of past and current other-related information) in @entity2 @entity0 . Correlation differences of the PCC/precuneus activation with the cognitive insight in @entity0 with @entity2 and @entity1 might reflect an important difference between these disorders, which may help to further explore potentially distinguishing markers.

title: Brain activation during self- and other-reflection in @entity2 with a history of psychosis: Comparison to XXXX .

answer: @entity1


abstract: The order Herpesvirales encompasses viruses that share structural, genetic, and biological properties. However, members of this order infect hosts ranging from molluscs to @entity0 . It is currently divided into three phylogenetically related families. The Alloherpesviridae family contains viruses infecting fish and amphibians. There are 12 alloherpesviruses described to date, 10 of which infect fish. Over the last decade, @entity2 (CyHV-3) infecting common and @entity1 @entity1 has emerged as the archetype of fish alloherpesviruses. Since its first description in the late 1990s, this virus has induced important economic losses in common and @entity1 @entity1 worldwide. It has also had negative environmental implications by affecting wild @entity1 populations. These negative impacts and the importance of the host species have stimulated studies aimed at developing diagnostic and prophylactic tools. Unexpectedly, the data generated by these applied studies have stimulated interest in CyHV-3 as a model for fundamental research. This review intends to provide a complete overview of the knowledge currently available on CyHV-3.

title: XXXX : An Archetype of Fish Alloherpesviruses.

answer: @entity2


abstract: UNASSIGNED: The goal of this study was to evaluate the diagnostic accuracy, cost-effectiveness and appropriate use of SPECT myocardial perfusion imaging (SMPI) versus @entity4 ( @entity4 ) in the preoperative evaluation of @entity0 for kidney transplantation. METHODS: A single-institution, retrospective study was performed. SMPI was performed with regadenoson and @entity4 predominantly with @entity2 . Findings on subsequent coronary angiography were correlated. Utilizing reimbursements from the Center for Medicare Services (CMS), a cost analysis for SMPI versus @entity4 was modeled. RESULTS: 113 @entity0 underwent imaging (53 SMPI and 60 @entity4 ). 100% of SMPI studies were diagnostic compared to only 80% (48/60) in the @entity4 group, and this result was statistically significant (X2 = 7.96, P < 0.01). The most common reason for a non-diagnostic test was not reaching target heart rate. In the SMPI group, 15% (8/53) had @entity1 on imaging and all had subsequent coronary angiography which confirmed obstructive coronary lesions. One @entity0 with negative SMPI had subsequent angiogram that was negative. In the @entity4 group, 5% (3/60) had @entity1 on imaging and two had subsequent angiography, which were negative. Three of 12 @entity0 with non-diagnostic exams underwent further testing. One @entity0 had a follow-up positive SMPI but no subsequent coronary angiography. The other two @entity0 underwent coronary angiography that were negative. Of the 45 negative @entity4 , six (13%) had angiography with positive result for obstructive @entity3 in 3/6. For modeling of cost analysis, CMS rates of  1,173 and  1,521 were utilized for SMPI and @entity4 respectively. The model assumes that all non-diagnostic imaging would be referred for further stress testing (i.e. non-diagnostic @entity4 would be referred for SMPI). This model estimates that initial non-invasive testing with @entity4 versus SMPI results in 50% greater cost. CONCLUSION: For pre-operative evaluation of kidney transplantation, SMPI is more often diagnostic than @entity4 . A cost model estimates that initial non-invasive diagnostic testing with @entity4 would result in approximately 50% greater cost compared to SMPI. Our data also suggests that SMPI has greater diagnostic accuracy than @entity4 . Therefore, this single institution experience supports SMPI as the more appropriate test.

title: Nuclear Myocardial Perfusion Imaging versus Stress Echocardiography in the Preoperative Evaluation of XXXX for Kidney Transplantation.

answer: @entity0


abstract: UNASSIGNED: Long-term outcome after closure of isolated @entity2 (ICCAF) is poorly documented. To assess late outcome after ICCAF closure, a 1983-2013 retrospective study included all @entity0 who attempted an ICCAF closure and whose follow-up was >= 1  year. ICCAF was diagnosed in 23 @entity0 [median age 6.9  years (0.1-70.5  years), 13 @entity0 ]. ICCAF was symptomatic in 12 @entity0 (52.2  %). First intervention was either a transcatheter embolization (n  =  19 @entity0 , 82.6  %) or a surgical ligation (n  =  4 @entity0 , 17.4  %). After a follow-up of 9.0  years (2.8-33.5), neither @entity1 nor late ischemic event occurred but one @entity0 was transplanted, because of postoperative @entity3 . Late ICCAF recanalization occurred in eight @entity0 , leading to successful embolization of the shunt in all @entity0 after a delay of 9.8  years (5.7-13.8  years) from the first intervention. Re-intervention occurred later in @entity0 (p  =  0.0027), with a 50 and 37.5  % freedom from re-intervention in adults compared to a 100 and 89.0  % in @entity0 , respectively, at 1 and 6  years of follow-up. At last follow-up, coronary artery diameter had decreased from a mean z score of 12.0      7.7 to a mean z score of 6.0      6.0 (p  =  0.002). Long-term outcome after ICCAF closure is excellent, with neither @entity1 nor late ischemic event, and a significant decrease in coronary artery diameter with time. Late follow-up is of paramount importance, as one-third of @entity0 will require a re-intervention for late shunt recanalization.

title: Closure of Isolated XXXX : Long-Term Outcomes and Rate of Re-intervention.

answer: @entity2


abstract: OBJECTIVE: The primary objective was to define the maximum tolerated dose (MTD) and dose-limiting @entity1 (DLT) of IV @entity6 and IP @entity5 in @entity0 with recurrent ovarian (OV), @entity8 . Secondary objectives included response rate, time to progression, pharmacokinetics (PK) and quality of life (QoL). METHODS: @entity0 received @entity6 75mg/m(2) IV day (d) 1 and @entity5 escalating from 50mg/m(2) @entity9 every 3weeks using a 3+3 design. Treatment continued until disease progression, remission, or intolerable @entity1 . Plasma and IP samples were taken to determine drug concentrations. @entity4 Anderson Symptom Inventory and symptom interference scale were completed weekly. RESULTS: Thirteen @entity0 were included. Median number of cycles was 6 (range 1-10). Ten @entity0 had measureable disease. Best response was partial response (PR-2), stable disease ( @entity2 -7), and progressive disease (PD-1). Twenty-one Grades 3-4 @entity1 were noted, commonly hematologic. Two @entity0 had DLTs: prolonged @entity7 (1) and @entity3 (1). MTD was d1 @entity6 75mg/m(2) IV and d2 @entity5 50mg/m(2) IP. Symptom burden peaked week one and returned to baseline by week two of each cycle on dose level 1. Dose level 2 had persistently high symptom burden and interference. At IP @entity5 doses of 50mg/m(2), total unbound drug exposure (AUC) averaged 8 times larger and Cmax reached concentrations 50-fold greater in IP fluid compared to plasma. CONCLUSIONS: @entity6 75mg/m(2) IV d1 and @entity5 50mg/m(2) @entity9 is the MTD. Most @entity0 had PR or @entity2 . @entity0 -reported outcomes demonstrate temporary but tolerable decrements in QoL. IP @entity5 provides PK advantages over IV administration.

title: Phase I study of intravenous (IV) @entity6 and intraperitoneal (IP) XXXX in recurrent ovarian and fallopian tube cancer.

answer: @entity5


abstract: OBJECTIVE: The primary objective was to define the maximum tolerated dose (MTD) and dose-limiting @entity1 (DLT) of IV @entity6 and IP @entity5 in @entity0 with recurrent ovarian (OV), @entity8 . Secondary objectives included response rate, time to progression, pharmacokinetics (PK) and quality of life (QoL). METHODS: @entity0 received @entity6 75mg/m(2) IV day (d) 1 and @entity5 escalating from 50mg/m(2) @entity9 every 3weeks using a 3+3 design. Treatment continued until disease progression, remission, or intolerable @entity1 . Plasma and IP samples were taken to determine drug concentrations. @entity4 Anderson Symptom Inventory and symptom interference scale were completed weekly. RESULTS: Thirteen @entity0 were included. Median number of cycles was 6 (range 1-10). Ten @entity0 had measureable disease. Best response was partial response (PR-2), stable disease ( @entity2 -7), and progressive disease (PD-1). Twenty-one Grades 3-4 @entity1 were noted, commonly hematologic. Two @entity0 had DLTs: prolonged @entity7 (1) and @entity3 (1). MTD was d1 @entity6 75mg/m(2) IV and d2 @entity5 50mg/m(2) IP. Symptom burden peaked week one and returned to baseline by week two of each cycle on dose level 1. Dose level 2 had persistently high symptom burden and interference. At IP @entity5 doses of 50mg/m(2), total unbound drug exposure (AUC) averaged 8 times larger and Cmax reached concentrations 50-fold greater in IP fluid compared to plasma. CONCLUSIONS: @entity6 75mg/m(2) IV d1 and @entity5 50mg/m(2) @entity9 is the MTD. Most @entity0 had PR or @entity2 . @entity0 -reported outcomes demonstrate temporary but tolerable decrements in QoL. IP @entity5 provides PK advantages over IV administration.

title: Phase I study of intravenous (IV) XXXX and intraperitoneal (IP) @entity5 in recurrent ovarian and fallopian tube cancer.

answer: @entity6


abstract: OBJECTIVE: The 12-month (M), phase 3, double-blind, randomised TRANSFORMS study demonstrated significant benefits of fingolimod 0.5 or 1.25   mg over interferon b-1a (IFNb-1a) in @entity0 with relapsing-remitting @entity1 . We report the results of long-term (up to 4.5   years) extension of TRANSFORMS. METHODS: @entity0 randomised to fingolimod (0.5/1.25   mg) in the core phase continued the same dose (continuous-fingolimod) in the extension, whereas those on IFNb-1a were re-randomised (1:1) to fingolimod (IFN-switch; IFN: 0.5/1.25   mg). Outcomes included annualised relapse rate (ARR), confirmed disability progression and MRI measures. Results are presented here for the continuous-fingolimod 0.5   mg and pooled IFN-switch groups. RESULTS: Of the 1027 @entity0 who entered the extension, 772 (75.2%) completed the study. From baseline to the end of the study (EOS), ARR in @entity0 on continuous-fingolimod 0.5   mg was significantly lower than in the IFN-switch group (M0-EOS: 0.17 vs 0.27). After switching to fingolimod (M0-12 vs M13-EOS), @entity0 initially treated with IFN had a 50% reduction in ARR (0.40 vs 0.20), reduced MRI activity and a lower rate of brain volume loss. In a post hoc analysis, the proportion of IFN-switch @entity0 with no evidence of disease activity increased by approximately 50% in the first year after switching to fingolimod treatment (44.3% to 66.0%). The safety profile was consistent with that observed in the core phase. CONCLUSIONS: These results support a continued effect of long-term fingolimod therapy in maintaining a low rate of disease activity and sustained improved efficacy after switching from IFNb-1a to fingolimod. CLINICAL TRIAL REGISTRATION NO: NCT00340834.

title: Long-term (up to 4.5   years) treatment with fingolimod in XXXX : results from the extension of the randomised TRANSFORMS study.

answer: @entity1


abstract: BACKGROUND: The rate of progression of the disease depends on various factors and the @entity1 microenvironment takes not the last place among them. One part of researchers argues that the presence of @entity1 -infiltrating leukocytes serves as a favorable marker of the disease. There exists a completely different point of view on the matter. The investigation of the effects of the inflammatory infiltration on the course of @entity0 process. METHODS: We found a pronounced inflammatory infiltration in the @entity1 microenvironment in 24 cases. Nineteen cases of IDC without inflammatory infiltration were used as a control group. Immunohistochemical reaction showed expression of @entity8 , PR, @entity7 / @entity7 , @entity11 , @entity13 , @entity4 , CD3, @entity12 , @entity9 and Myeloperoxidase receptors. Mathematical calculations were done using Microsoft Excel 2010 with 12.0.5 Attestat option. RESULTS: We have determined five variants of immune microenvironment: interstitial, trabecular, nodular, diffuse and mixed. We have established a direct correlation between the expression of @entity8 and PR and indirect correlation between the receptors of @entity3 hormones and @entity7 /neo in both groups of @entity0 . @entity7 /neo positive @entity1 in 100% of cases were accompanied by the presence of @entity6 proteins. There was a combination of @entity4 presence with the @entity3 receptors expression in 90 % of cases. There was found the indirect correlation between the presence of B lymphocytes and expression of @entity3 receptors. CONCLUSIONS: The presence of B lymphocytes in an inflammatory infiltrate leads to the disappearance of @entity2 receptors and @entity5 receptors. It provokes the accumulation of @entity10 in a cell. It contributes to the stabilization of @entity7 / @entity7 receptors and most proteins that promote @entity1 progression. VIRTUAL SLIDES: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1362330168161694.

title: Immune microenvironment as a factor of XXXX progression.

answer: @entity0


abstract: BACKGROUND: The foundation of recommended @entity2 management in young @entity0 is increased fluids and continued feeding. This increase in fluids is necessary to replace those lost during @entity2 and ultimately prevent @entity4 . There may be an opportunity to prevent deaths in @entity0 under five by discouraging the practice of reducing or curtailing fluids during @entity2 episodes across different settings worldwide. METHODS: We quantify and describe the extent of fluid curtailment in @entity0 with @entity2 in a selection of countries (Burkina Faso, Democratic Republic of Congo, Ethiopia, Nigeria, Tanzania, and Uganda) with high burden of @entity2 -related mortality with national cross sectional survey data. We examine the practice of fluid curtailment in these countries and its relationship to @entity0 and household traits and to characteristics of @entity2 management. RESULTS: The prevalence of fluid curtailment among @entity0 under five with @entity2 is strikingly high in these countries: 55 % in Nigeria, 49 % in Ethiopia, 44 % in Uganda, 37 % in Tanzania, 36 % in DR Congo and 32 % in Burkina Faso. Fluid curtailment is associated with giving less food, potentially worsening the impact of this harmful practice. @entity0 who were reported to have had fluids curtailed during @entity2 episodes were also 3.51 (95 % confidence, 2.66 - 4.64) times more likely to be reported to have food withheld (a   =   0.05; p   <   0.001). @entity0 who received care from non-governmental providers, and those who were breastfed were more likely to have their fluids curtailed, as were @entity0 with an unimproved water source. @entity0 of poorer or less educated mothers and those living in rural areas are more likely to have curtailed fluids, compared to @entity0 of less poor or more educated mothers, or those living in urban areas. CONCLUSIONS: The harmful practice of curtailing fluids for a @entity0 with @entity2 is highly prevalent, representing an increased risk of @entity3 due to @entity2 , including @entity1 , especially for @entity0 in specific subgroups.

title: Fluid curtailment during childhood XXXX : a countdown analysis.

answer: @entity2


abstract: UNASSIGNED: The biotechnological task of controlling @entity0 aging will evidently be complex, given the failure of all simple strategies for accomplishing this task to date. In view of this complexity, a multi-step approach will be necessary. One precedent for a multi-step biotechnological success is the burgeoning control of @entity0 infectious diseases from 1840 to 2000. Here we break down progress toward the control of @entity2 into four key steps, each of which have analogs for the control of aging. (1) Agreement about the fundamental nature of the medical problem. (2) Public health measures to mitigate some of the factors that exacerbate the medical problem. (3) Early biotechnological interventions that ward off the more tractable disease etiologies. (4) Deep understanding of the underlying biology of the diseases involved, leading in turn to comprehensive control of the medical problems that they pose. Achievement of all four of these steps has allowed most @entity0 who live in Western countries to live largely free of imminent @entity3 due to @entity2 . Accomplishing the equivalent feat for aging over this century should lead to a similar outcome for @entity1 . Neither infection nor aging will ever be entirely abolished, but they can both be rendered minor causes of @entity3 and disability.

title: Four steps toward the control of aging: following the example of XXXX .

answer: @entity2


abstract: OBJECTIVE: The prognostic value of ambulatory arterial stiffness index (AASI) is not well established in resistant @entity2 as much as in general population. Our aim was to evaluate, on resistant @entity2 @entity0 ( @entity6 , the prognostic significance of AASI as an independent predictor of cardiovascular events (CV). DESIGN AND METHOD: Retrospective observational analysis of @entity6 outpatients defined by abnormal 24h ambulatory blood pressure monitoring (24h ABPM) under 3 or more anti @entity2 drugs. The follow-up was defined since the first appointment until the 31st December 2014 or until a CV event ( @entity5 , @entity1 , @entity3 or @entity4 ). RESULTS: Included 217 @entity0 , 119 male and 98 female, mean age 56,4+/- 14,6 years. During a mean follow-up of 6,0+/-3,1 years, 53 @entity0 (24,4%) had CV (5,1% acute coronary syndromes, 10,1% strokes and 9,2% acute @entity3 and @entity4 ). There were 24 deaths (50% cardiovascular and 50% non-cardiovascular). When analysed those with CV events versus without, those with events showed more frequently reverted dipper (22 % vs 12%) and extreme dipper patterns (10% vs 4,4%) X2 8,242 p<0.05)) and worse AASI (0.4918 vs 0,4046 p<0,02). In analysis of Kaplan Meier survival curves free of events those who were above median (cut off 0,41), of AASI had worse prognosis compared to those who were below it (Log Rank 8,347, p= 0.004) for CV event and (Log Rank 9,562, p=0,002) for global mortality. In a Cox hazard model adjusted for confounding factors ((sex, age, body mass index (BMI) and systolic blood pressure (SBP)) AASI was an independent predictor for CV event (HR 8,34; 95%CI 1,76-39,57; p 0,008) even when analysed in the same model with SBP night fall, 24h PP, and 24h SBP (HR 11,20; 95% CI 2,16 -58,15; p 0,004) and also for global mortality (HR 42,64; 95%CI 3,72-488,58; p 0,003). CONCLUSIONS: In this population AASI was the ABPM marker with the strongest predictor value for CV. Perhaps in resistant @entity2 AASI (traducing higher arterial stiffness) is a more potent CV predictor than in non resistant essential @entity2 .

title: 6A.05: THE PROGNOSTIC VALUE OF AMBULATORY ARTERIAL STIFFNESS INDEX AS A PREDICTOR OF CARDIOVASCULAR EVENTS IN RESISTANT HYPERTENSIVE XXXX ?

answer: @entity0


abstract: UNASSIGNED: The aim of the study was to determine the effects of two different fat sources ( @entity2 oil (SO) and beef tallow (BT)) in dry extruded @entity1 diets on the intake of food and metabolizable energy (ME), on faecal characteristics and apparent total tract digestibility (ATTD) of nutrients and energy. Ten adult @entity1 of different breeds were used in a Latin square design. Five experimental diets were designed from a basal diet. A Control diet was coated with 1% SO and four other diets were obtained by coating the basal diet with 6.5% and 13% of SO or BT. The Control, 6.5% and 13% coated diets contained approximately 8.5%, 15% and 20% fat, respectively. The @entity1 had similar @entity0 ( @entity0 ) intakes and, consequently, higher ME intakes with an increased fat content for both sources (p  <  0.05). Fat digestibility was highest for Diet SO13% (p  <  0.05). The ATTD of @entity0 and organic matter was highest (p  <  0.05) for Diets SO13% and BT13%. Fat coating improved the faecal score, especially for Diet BT13%. The dietary ratios of protein:fat: @entity3 [% of ME] were close to AAFCO's estimates. For SO a higher ATTD (99.1%) and ME content (38.88  MJ/kg) was estimated than for BT (ATTD 92.9% and 36.37 MJ ME/kg). Both SO and BT can comprise up to 13% of the diet. However, SO was more susceptible to leaking from the kibbles with the coating method applied.

title: XXXX oil and beef tallow in dry extruded diets for adult @entity1 .

answer: @entity2


abstract: UNASSIGNED: The aim of the study was to determine the effects of two different fat sources ( @entity2 oil (SO) and beef tallow (BT)) in dry extruded @entity1 diets on the intake of food and metabolizable energy (ME), on faecal characteristics and apparent total tract digestibility (ATTD) of nutrients and energy. Ten adult @entity1 of different breeds were used in a Latin square design. Five experimental diets were designed from a basal diet. A Control diet was coated with 1% SO and four other diets were obtained by coating the basal diet with 6.5% and 13% of SO or BT. The Control, 6.5% and 13% coated diets contained approximately 8.5%, 15% and 20% fat, respectively. The @entity1 had similar @entity0 ( @entity0 ) intakes and, consequently, higher ME intakes with an increased fat content for both sources (p  <  0.05). Fat digestibility was highest for Diet SO13% (p  <  0.05). The ATTD of @entity0 and organic matter was highest (p  <  0.05) for Diets SO13% and BT13%. Fat coating improved the faecal score, especially for Diet BT13%. The dietary ratios of protein:fat: @entity3 [% of ME] were close to AAFCO's estimates. For SO a higher ATTD (99.1%) and ME content (38.88  MJ/kg) was estimated than for BT (ATTD 92.9% and 36.37 MJ ME/kg). Both SO and BT can comprise up to 13% of the diet. However, SO was more susceptible to leaking from the kibbles with the coating method applied.

title: @entity2 oil and beef tallow in dry extruded diets for adult XXXX .

answer: @entity1


abstract: UNASSIGNED: Data collected during the 2012 @entity13 ( @entity13 ) epidemic in the Democratic Republic of the Congo were analysed for clinical signs, symptoms and case fatality of @entity13 caused by @entity15 ( @entity15 ), establishment of differential diagnoses, description of medical treatment and evaluation of the quality of clinical documentation. In a quantitative observational prospective study, global epidemiological data from 52 @entity0 (34 @entity0 within the community, 18 @entity0 treated in the Ebola Treatment Centre) were entered anonymously into a database, subsequently matched and analysed. Relevant findings include an over-representation of females among community @entity13 cases (85.3%) and of community @entity13 cases in the age group of 15-54 years (82.4%). All ETC @entity0 had @entity3 (55.6% of all 18 ETC @entity0 during their hospital stay) or self-reported @entity3 (88.2% upon admission) at some point of time during their illness. Major symptoms of ETC @entity0 during hospital stay included @entity11 (82.4%), @entity8 (82.4%), @entity10 (70.6%), sore throat/difficulty swallowing (70.6%), @entity14 (76.5%) and @entity6 (70.6%). Gastrointestinal signs and symptoms ( @entity6 , @entity4 , @entity7 ) (76.4%) as well as general @entity1 (94.1%) were frequent in ETC @entity0 . The median duration of @entity13 was 18 days, while the mean incubation period was 11.3 days. Differential diagnosis of @entity13 included @entity5 (28.3%), @entity12 (10.9%), and @entity2 (10.9%). There was also an important variation in clinical evolvement. Quality of documentation was adversely affected by the way @entity0 file contents were transferred from inside to outside the high-risk zone, entailing a mean mismatch value of 27.3% between @entity0 file contents inside vs. outside the high-risk zone. This study adds further description of @entity13 (frequently non-specific signs and symptoms, non frequent @entity9 , a long incubation period, long duration of disease) and emphasizes the need for improving clinical monitoring and documentation in @entity13 outbreak settings.

title: XXXX Outbreak in Isiro, Democratic Republic of the Congo, 2012: Signs and Symptoms, Management and Outcomes.

answer: @entity13


abstract: OBJECTIVES: This study aimed to evaluate the correlation of sonoelastographic features between @entity2 and unruptured @entity3 . METHODS: We performed a prospective survey of 27 @entity0 with clinically suspected @entity3 diagnosed by excisional biopsy with prebiopsy sonography and real-time sonoelastography. We statistically evaluated the correlation between elastographic and histopathologic features. To measure the relative hardness on elastography, the Rinside/Routside ratio was used to show the ratio of the elasticity inside and outside the cyst, where the random value R was defined as the median red pixel intensity/(median red pixel intensity + median green pixel intensity + median blue pixel intensity). RESULTS: Only 24 of the 27 @entity0 were enrolled. Among the 24 diagnosed @entity3 , 13 were @entity1 , and 11 were @entity2 based on histopathologic examination. There was no correlation between sonographically and histopathologically measured cyst diameters. The Rinside/Routside ratio was significantly higher in @entity1 than @entity2 (mean    SD, 1.16    0.15 versus 1.04    0.13; P = .047). All values below the cutoff point were considered to indicate @entity2 , and the cutoff value was set to 1.0919, which afforded sensitivity of 83.3% and specificity of 66.7%. CONCLUSIONS: Real-time sonoelastography is able to detect differences in tissue elasticity between @entity2 and unruptured @entity3 . This study shows the utility of real-time sonoelastography, which has important implications for treatment planning.

title: Utility of Sonoelastography in Differentiating Ruptured From Unruptured Epidermal Cysts and Implications for XXXX Care.

answer: @entity0


abstract: BACKGROUND AND AIMS: Adsorptive granulocyte/monocyte apheresis (GMA) has shown promising efficacy in the treatment of @entity0 with @entity1 ( @entity1 ). But a sham-controlled study was negative. A post-hoc analysis of this trial may haul out @entity0 responding to GMA. METHODS: A total of 168 @entity1 @entity0 with a disease activity (DAI) between 6 and 11 were enrolled in this study. Out of 168 @entity0 , 112 received GMA and 56 sham apheresis. The basis for this post hoc analysis is the clinical study report issued by Otsuka America Pharmaceutical. RESULTS: Baseline histology was available for 165 @entity0 . Only 38% (63 of 165) of @entity0 showed microscopic erosion/ @entity2 (group P). The remaining 62% of @entity0 did not show microscopic erosion/ @entity2 (group A). The @entity0 in group P showed significantly higher DAI, flexible proctosigmoidoscopy score and neutrophil infiltration into the colonic mucosa than those in group A (p = 0.0132, p = 0.0243 and p < 0.0001, respectively). Likewise, group P @entity0 had a significantly (p = 0.0275) higher remission rate (11 of 46; 23.9%) when treated with GMA than with sham procedure (0 of 17; 0%). CONCLUSIONS: @entity0 in group P who had more active @entity1 than those in group A showed clear clinical efficacy in response to GMA. We believe that true DAI should be specified for further randomized controlled trials.

title: Granulocyte/Monocyte Adsorptive Apheresis in Moderate to Severe XXXX --Effective or Not?

answer: @entity1


abstract: BACKGROUND: The high acute costs of @entity1 and acute @entity1 are well established, particularly in terms of direct medical costs. The costs associated with lost work productivity have been described in a broad sense, but little is known about workplace absenteeism or short term disability costs among high cardiovascular risk @entity0 . The objective of this study was to quantify workplace absenteeism (WA) and @entity3 ( @entity3 ) hours and costs associated with @entity1 and related clinical procedures (CVERP) in United States employees with high cardiovascular risk. METHODS: Medical, WA and/or @entity3 data from the Truven Health MarketScan   Research Databases were used to select full-time employees aged 18-64 with @entity2 during 2002-2011. Two cohorts (with and without CVERP) were created and screened for medical, drug, WA, and @entity3 eligibility. The CVERP cohort was matched with a non-CVERP cohort using propensity score matching. Work loss hours and indirect costs were calculated for @entity0 with and without CVERP and by CVERP type. Wages were based on the 2013 age-, gender-, and geographic region-adjusted wage rate from the United States Bureau of Labor Statistics. RESULTS: A total of 5,808 WA-eligible, 21,006 @entity3 -eligible, and 3,362 combined WA and @entity3 eligible @entity0 with CVERP were well matched to @entity0 without CVERP, creating three cohorts of @entity0 with CVERP and three cohorts of @entity0 without CVERP. Demographics were similar across cohorts (mean age 52.2-53.1  years, male 81.3-86.8  %). During the first month of follow-up, @entity0 with CVERP had more WA/ @entity3 -related hours lost compared with @entity0 without CVERP (WA-eligible: 23.4 more hours, @entity3 -eligible: 51.7 more hours, WA and @entity3 -eligible: 56.3 more hours) (p   <   0.001). Corresponding costs were  683,  895, and  1,119 higher, respectively (p   <   0.001). Differences narrowed with longer follow-up. In the first month and year of follow-up, @entity0 with coronary artery bypass graft experienced the highest WA/ @entity3 -related hours lost and costs compared with @entity0 with other CVERP. CONCLUSIONS: CVERP were associated with substantial work loss and indirect costs. Prevention or reduction of CVERP could result in WA and @entity3 -related cost savings for employers.

title: Productivity loss and indirect costs associated with XXXX and related clinical procedures.

answer: @entity1


abstract: PURPOSE: Proper delineation of ocular anatomy in 3-dimensional (3D) imaging is a big challenge, particularly when developing treatment plans for @entity5 . Magnetic resonance imaging (MRI) is presently used in clinical practice for diagnosis confirmation and treatment planning for treatment of @entity3 in @entity0 , where it serves as a source of information, complementary to the fundus or ultrasonographic imaging. Here we present a framework to fully automatically segment the eye anatomy for MRI based on 3D @entity6 ( @entity6 ), and we validate the results and present a proof of concept to automatically segment pathological eyes. METHODS AND MATERIALS: Manual and automatic segmentation were performed in 24 images of healthy @entity0 ' @entity7 (3.29      2.15  years of age). Imaging was performed using a 3-T MRI scanner. The @entity6 consists of the lens, the vitreous humor, the sclera, and the @entity2 . The model was fitted by first automatically detecting the position of the eye center, the lens, and the optic nerve, and then aligning the model and fitting it to the @entity0 . We validated our segmentation method by using a leave-one-out cross-validation. The segmentation results were evaluated by measuring the overlap, using the Dice similarity coefficient (DSC) and the mean distance error. RESULTS: We obtained a DSC of 94.90      2.12% for the sclera and the @entity2 , 94.72      1.89% for the vitreous humor, and 85.16      4.91% for the lens. The mean distance error was 0.26      0.09  mm. The entire process took 14  seconds on average per eye. CONCLUSION: We provide a reliable and accurate tool that enables clinicians to @entity4 , the @entity2 , the vitreous humor, and the lens, using MRI. We additionally present a proof of concept for fully automatically segmenting eye pathology. This tool reduces the time needed for eye shape delineation and thus can help clinicians when planning eye treatment and confirming the extent of the @entity1 .

title: Automatic Segmentation of the Eye in 3D Magnetic Resonance Imaging: A Novel Statistical Shape Model for Treatment Planning of XXXX .

answer: @entity3


abstract: OBJECTIVES: We compared the incidence of the @entity2 of pregnancy in @entity1 @entity0 with @entity0 of a normal body mass index (BMI). STUDY DESIGN: Prospective observational study in which BMI was calculated accurately early in pregnancy. @entity0 were enrolled after a sonographic confirmation of an ongoing pregnancy. To reduce confounding variables the study was confined to white European @entity0 with a singleton pregnancy. MAIN OUTCOME MEASURES: Incidence of @entity3 and gestational @entity2 . RESULTS: In 2230 @entity0 , 16.8% were @entity1 . @entity3 was diagnosed in 3.3% (n=74) and gestational @entity2 in 3.0% (n=67). Both @entity3 (p=0.01) and gestational @entity2 (p<0.01) were common in @entity1 @entity0 compared with normal weight @entity0 . Overall 13.1% of @entity1 @entity0 developed a @entity2 disorder during pregnancy. When analysed by parity @entity3 occurred in 2.1% of primigravidas and 0.3% of multigravidas. @entity3 was @entity1 multigravidas (p=0.001), but not @entity1 primigravidas, suggesting that parity is more influential than obesity in the development of @entity3 . CONCLUSIONS: Obese multigravidas are more likely to develop @entity2 in pregnancy and @entity1 primigravidas are more likely to develop gestational @entity2 . This is important in clinical practice because maternal weight, unlike parity, is potentially modifiable before or during pregnancy.

title: Body mass index and XXXX of pregnancy.

answer: @entity2


abstract: INTRODUCTION: Hyperglycosylated @entity0 chorionic gonadotrophin ( @entity4 ), produced by the placental trophoblast cells, is involved in placental development in early pregnancy. Decreased second trimester urine @entity4 is associated with @entity3 , which may be a sign of @entity1 preceding symptoms of the disease. OBJECTIVES: To study whether maternal second trimester serum @entity4 concentrations predict later development of @entity3 . METHODS: Fifty-five @entity0 with subsequent @entity3 , 21 @entity0 with gestational @entity2 , 30 normotensive @entity0 with small-for-gestational-age (SGA) @entity0 and 83 controls with uneventful pregnancies were included in the study. Their serum hCG and @entity4 concentrations were analyzed by fluoroimmunoassay at 14-17weeks of gestation. The proportion of @entity4 of total hCG (% @entity4 ) was calculated and converted to multiples of the median (MoMs) of the controls. MoMs of the groups were compared by Mann-Whitney U test. Pearson's correlation was used to analyze correlations between clinical characteristics and serum marker concentrations. The results are given as medians with 95% confidence intervals (95% CI). A two-tailed P<0.05 was considered significant. RESULTS: The concentrations of @entity4 and % @entity4 decreased with advancing gestational weeks in @entity0 with subsequent @entity3 (r=-0.289, p=0.032 and r=-0.464, p<0.001), but not in @entity0 in the other groups. There was a tendency towards lower concentrations of @entity4 and % @entity4 in @entity0 with subsequent @entity3 than in controls. The median MoMs of % @entity4 were 0.89 (95% CI,0.79-1.00) in @entity0 with subsequent @entity3 and 1.00 (0.91-1.11) in controls. The corresponding values for @entity0 with subsequent gestational @entity2 were 1.00 (0.86-1.16), for those with subsequent SGA @entity0 they were 1.09 (0.89-1.23). The difference between @entity3 and the other groups together was significant (p=0.029). CONCLUSION: Earlier studies suggest that decreased urine @entity4 concentrations reflect changes in placental function that precede the development of @entity3 . At 14-17weeks of gestation, the serum concentrations of @entity4 showed moderate validity to predict later development of @entity3 . Further studies on the utility of @entity4 for prediction of subsequent @entity3 are warranted.

title: OS009. Second trimester serum hyperglycosylated @entity0 chorionic gonadotrophin and XXXX .

answer: @entity3


abstract: INTRODUCTION: Hyperglycosylated @entity0 chorionic gonadotrophin ( @entity4 ), produced by the placental trophoblast cells, is involved in placental development in early pregnancy. Decreased second trimester urine @entity4 is associated with @entity3 , which may be a sign of @entity1 preceding symptoms of the disease. OBJECTIVES: To study whether maternal second trimester serum @entity4 concentrations predict later development of @entity3 . METHODS: Fifty-five @entity0 with subsequent @entity3 , 21 @entity0 with gestational @entity2 , 30 normotensive @entity0 with small-for-gestational-age (SGA) @entity0 and 83 controls with uneventful pregnancies were included in the study. Their serum hCG and @entity4 concentrations were analyzed by fluoroimmunoassay at 14-17weeks of gestation. The proportion of @entity4 of total hCG (% @entity4 ) was calculated and converted to multiples of the median (MoMs) of the controls. MoMs of the groups were compared by Mann-Whitney U test. Pearson's correlation was used to analyze correlations between clinical characteristics and serum marker concentrations. The results are given as medians with 95% confidence intervals (95% CI). A two-tailed P<0.05 was considered significant. RESULTS: The concentrations of @entity4 and % @entity4 decreased with advancing gestational weeks in @entity0 with subsequent @entity3 (r=-0.289, p=0.032 and r=-0.464, p<0.001), but not in @entity0 in the other groups. There was a tendency towards lower concentrations of @entity4 and % @entity4 in @entity0 with subsequent @entity3 than in controls. The median MoMs of % @entity4 were 0.89 (95% CI,0.79-1.00) in @entity0 with subsequent @entity3 and 1.00 (0.91-1.11) in controls. The corresponding values for @entity0 with subsequent gestational @entity2 were 1.00 (0.86-1.16), for those with subsequent SGA @entity0 they were 1.09 (0.89-1.23). The difference between @entity3 and the other groups together was significant (p=0.029). CONCLUSION: Earlier studies suggest that decreased urine @entity4 concentrations reflect changes in placental function that precede the development of @entity3 . At 14-17weeks of gestation, the serum concentrations of @entity4 showed moderate validity to predict later development of @entity3 . Further studies on the utility of @entity4 for prediction of subsequent @entity3 are warranted.

title: OS009. Second trimester serum hyperglycosylated XXXX chorionic gonadotrophin and @entity3 .

answer: @entity0


abstract: INTRODUCTION: Failure of the trophoblast to appropriately invade uterine spiral arteries is thought to be an initiating event in @entity3 , a disorder associated with @entity2 . @entity6 characterised by low plasma levels of high density lipoproteins (HDL) and elevated @entity4 has also been described in @entity3 . The pro-inflammatory cytokine @entity1 inhibits trophoblast invasion of uterine endothelial cells. Previous work using an in vitro JEG-3 cell/Uterine endothelial cell co-culture model investigated the effect of apoliopoprotein A-I, the main apolipoprotein component of HDL, on trophoblast incorporation into endothelial tubules in the presence and absence of @entity1 . These effects are now investigated using the @entity0 invasive trophoblast cell line HTR-8/SVneo. OBJECTIVES: This study asks if @entity5 , which has established anti-inflammatory properties, can protect against the deleterious effect of @entity1 on trophoblast-endothelial cell interactions. METHODS: The in vitro trophoblast-uterine endothelial cell co-culture model was used to investigate the effect of @entity5 on trophoblast incorporation into endothelial tubules in the presence and absence of @entity1 . Uterine endothelial cells were pre-incubated with lipid free @entity5 (final @entity5 concentration 1 mg/mL) for 16h prior to seeding on matrigel coated plates. Tubules formed within 4h. Fluorescence-labelled HTR-8/SVneo trophoblast cells were then co-cultured with the endothelial cells  @entity1 (final concentration of 0.2ng/mL). Bright field and fluorescent images were captured after 24h. The effect of @entity1 on HTR-8/SVneo cell invasion was quantified with Image J software. Integration of HTR-8/SVneo trophoblast cells into uterine endothelial tubular networks was also imaged using live cell imaging techniques (Zeiss Axiovert). RESULTS: @entity1 inhibited HTR-8/SVneo (trophoblast) cell integration into endothelial tubular structures by 24.1  3.7% p<0.001. This effect was reversed when the endothelial cells were pre-incubated for 16h with lipid free @entity5 (p<0.001 compared to non-incubated cells). Live cell images of the co-culture clearly demonstrate a disruption to the normal integration of trophoblast into endothelial tubular structures in the presence of @entity1 . The protective effect conferred by pre-incubation of endothelial cells with @entity5 against @entity1 is also clearly visible. CONCLUSION: @entity5 has been shown to enhance trophoblast-endothelial cell integration in the presence of a pro-inflammatory stimulus. A healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.

title: OS041. @entity5 protects normal integration of the trophoblast into endothelial cellular networks in an in vitro model of XXXX .

answer: @entity3


abstract: INTRODUCTION: Failure of the trophoblast to appropriately invade uterine spiral arteries is thought to be an initiating event in @entity3 , a disorder associated with @entity2 . @entity6 characterised by low plasma levels of high density lipoproteins (HDL) and elevated @entity4 has also been described in @entity3 . The pro-inflammatory cytokine @entity1 inhibits trophoblast invasion of uterine endothelial cells. Previous work using an in vitro JEG-3 cell/Uterine endothelial cell co-culture model investigated the effect of apoliopoprotein A-I, the main apolipoprotein component of HDL, on trophoblast incorporation into endothelial tubules in the presence and absence of @entity1 . These effects are now investigated using the @entity0 invasive trophoblast cell line HTR-8/SVneo. OBJECTIVES: This study asks if @entity5 , which has established anti-inflammatory properties, can protect against the deleterious effect of @entity1 on trophoblast-endothelial cell interactions. METHODS: The in vitro trophoblast-uterine endothelial cell co-culture model was used to investigate the effect of @entity5 on trophoblast incorporation into endothelial tubules in the presence and absence of @entity1 . Uterine endothelial cells were pre-incubated with lipid free @entity5 (final @entity5 concentration 1 mg/mL) for 16h prior to seeding on matrigel coated plates. Tubules formed within 4h. Fluorescence-labelled HTR-8/SVneo trophoblast cells were then co-cultured with the endothelial cells  @entity1 (final concentration of 0.2ng/mL). Bright field and fluorescent images were captured after 24h. The effect of @entity1 on HTR-8/SVneo cell invasion was quantified with Image J software. Integration of HTR-8/SVneo trophoblast cells into uterine endothelial tubular networks was also imaged using live cell imaging techniques (Zeiss Axiovert). RESULTS: @entity1 inhibited HTR-8/SVneo (trophoblast) cell integration into endothelial tubular structures by 24.1  3.7% p<0.001. This effect was reversed when the endothelial cells were pre-incubated for 16h with lipid free @entity5 (p<0.001 compared to non-incubated cells). Live cell images of the co-culture clearly demonstrate a disruption to the normal integration of trophoblast into endothelial tubular structures in the presence of @entity1 . The protective effect conferred by pre-incubation of endothelial cells with @entity5 against @entity1 is also clearly visible. CONCLUSION: @entity5 has been shown to enhance trophoblast-endothelial cell integration in the presence of a pro-inflammatory stimulus. A healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.

title: OS041. XXXX protects normal integration of the trophoblast into endothelial cellular networks in an in vitro model of @entity3 .

answer: @entity5


abstract: BACKGROUND: Epidural analgesia is commonly used for @entity2 management during labor. Sometimes, @entity4 ( @entity4 ) occurs causing severely debilitating @entity1 , which may be associated with transient @entity3 . We investigated if auditory function may be impaired several years after @entity4 treated with epidural blood patch (EBP). METHODS: Sixty @entity0 ( @entity4 group) without documented @entity3 , who received EBP following @entity4 during labor between the years 2005-2011 were investigated in 2013 for auditory function using the following tests: otoscopic examination, tympanometry, pure tone audiometry, and transient-evoked otoacoustic emissions. Additionally, they responded to a questionnaire, the Speech, Spatial and Qualities (SSQ) of hearing, concerning perceived @entity3 . The results were compared to a control group of 20 healthy, non-pregnant @entity0 in the same age group. RESULTS: The audiometric test battery was performed 5.2 (1.9)  years after delivery. No significant differences were found between the @entity4 and the control groups in tympanometry or otoacoustic emissions. Pure tone audiometry revealed a significant but small (<  5  dB) difference between the @entity4 and control groups (P  <  0.05). The ability to hear speech in noise as measured by SSQ was significantly reduced in the @entity4 group compared to the control group (P  <  0.05). CONCLUSIONS: A minor @entity3 was detected in the @entity4 group compared to the control group in pure tone audiometry in some @entity0 and during speech-in-noise component several years after @entity4 treated with an epidural blood patch. This small residual @entity3 has minor clinical significance.

title: Auditory function following post-dural puncture XXXX treated with epidural blood patch. A long-term follow-up.

answer: @entity1


abstract: @entity3 ( @entity3 ) limits the benefits of radiotherapy in @entity0 with @entity1 . Radiation-induced differentiation of lung fibroblasts to myofibroblasts plays a key role in @entity3 . Recent studies have shown that mesenchymal stem cells (MSCs) can protect against @entity2 and that Wnt/ @entity5 signaling is involved in fibrotic processes. In the present study, we explored the therapeutic potential of @entity0 umbilical cord MSCs (HUMSCs) for preventing radiation-induced differentiation of @entity0 lung fibroblasts (HLFs) to myofibroblasts. There are two advantages in the use of HUMSCs; namely, they are easily obtained and have low immunogenicity. Irradiated HLFs were co-cultured with HUMSCs. Expression of a-smooth muscle actin ( @entity4 ), a myofibroblast marker, was measured by Western blot analysis and immunohistochemistry. Irradiation (X-rays, 5 Gy) induced the differentiation of HLFs into myofibroblasts, which was inhibited by co-culture with HUMSCs. Irradiation also caused activation of the canonical Wnt/ @entity5 signaling in HLFs, as judged by increased phosphorylation of glycogen synthase kinase 3b, nuclear accumulation of @entity5 , and elevated levels of @entity7 ( @entity7 ) in the conditioned medium. However, co-culture with HUMSCs attenuated the radiation-induced activation of the Wnt/ @entity5 signaling. We also measured the expression of @entity6 that can enhance the Wnt/ @entity5 signaling by stabilizing @entity5 . Co-culture with HUMSCs decreased @entity6 protein levels in irradiated nHLFs. Thus, co-culture with HUMSCs attenuated the radiation-induced activation of Wnt/ @entity5 signaling in HLFs, thereby inhibiting myofibroblastic differentiation of HLFs. Wnt/ @entity5 signaling is a potential therapeutic target for limiting @entity3 in @entity0 receiving radiotherapy for @entity1 .

title: Therapeutic Potential of Umbilical Cord Mesenchymal Stem Cells for Inhibiting Myofibroblastic Differentiation of Irradiated XXXX Lung Fibroblasts.

answer: @entity0


abstract: BACKGROUND: To determine the prevalence of uncontrolled LDL-C in @entity0 with high @entity4 ( @entity4 ) risks across Canada and to examine its related factors. METHODS: Non-pregnant adults >20  years-old, who had a lipid test completed between January 1, 2009 and December 31, 2011 and were included in the Canadian Primary Care Surveillance Network (CPCSSN) database were studied. The Framingham-Risk-Score was calculated to determine the risk levels. A serum LDL-C level of >2.0  mmol/L was considered as being poorly controlled. @entity0 with a previous record of a @entity3 , @entity7 , or an @entity6 were regarded as those under secondary prevention. Logistic regression modeling was performed to examine the factors associated with the LDL-C control. RESULTS: A total of 6,405 high-risk @entity0 were included in the study and, of this population, 68  % had a suboptimal LDL-C, which was significantly associated with the female gender (OR: 3.26; 95  % CI: 2.63-4.05, p   <   0.0001) and no medication therapy (OR: 6.31, 95  % CI: 5.21-7.65, p   <   0.0001). Those with comorbidities of @entity1 , @entity5 , @entity2 , and smokers had a better LDL-C control. Rural residents (OR: 0.64, 95  % CI: 0.52-0.78, p   <   0.0001), and those under secondary prevention (OR: 0.42; 95  % CI: 0.35-0.51, p   <   0.0001), were also more likely to have a better LDL-C control. CONCLUSION: A high proportion of high-cardiac risk @entity0 in Canadian primary care settings have suboptimal LDL-C control. A lack of medication therapy appears to be the major contributing factor to this situation.

title: Low density lipoprotein cholesterol control status among Canadians at risk for XXXX : findings from the Canadian Primary Care Sentinel Surveillance Network Database.

answer: @entity4


abstract: BACKGROUND: African American (AA) @entity1 are known to have poorer @entity0 survival than whites, and the differences may be related to underlying disparities in their clinical presentation or access to care. This study evaluated the relationship between demographic, treatment, and socioeconomic factors and @entity0 survival among @entity1 in southeast Michigan. METHODS: The population included 2387 @entity1 (34% AA) with American Joint Committee on @entity2 stage I to III @entity0 who were treated at the Henry Ford Health System (HFHS) from 1996 through 2005. Linked data sets from the HFHS, the Metropolitan Detroit @entity2 Surveillance System, and the US Census Bureau were used to obtain demographic and clinical information. Comorbidities were classified with the modified Charlson comorbidity index (CCI). Economic deprivation was categorized with a census tract-based @entity4 ( @entity4 ), which was stratified into 5 quintiles of increasing socioeconomic disadvantage. RESULTS: Compared with whites, AA @entity1 were significantly more likely to have larger, @entity5 -negative @entity2 and more comorbidities and to reside in an economically deprived area. In an unadjusted analysis, AAs had a significantly higher risk of @entity3 (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.16-1.59); however, after adjustments for clinical (age, stage, @entity5 , and CCI) and societal factors ( @entity4 ), the effect of race was not significant (HR, 1.13 [95% CI, 0.96-1.34] , and HR, 0.97 [0.80-1.19] respectively). CONCLUSIONS: Racial differences in @entity0 survival can be explained by clinical and socioeconomic factors. Nonetheless, AA @entity1 with @entity0 remain disproportionately affected by unfavorable @entity2 characteristics and economic deprivation, which likely contribute to their increased overall mortality. @entity2 2015;121:3668-3675.    2015 American @entity2 Society.

title: Racial differences in XXXX survival in a large urban integrated health system.

answer: @entity0


abstract: BACKGROUND: Malarial incidence, severity, dynamics and distribution of @entity1 are strongly determined by climatic factors, i.e., temperature, precipitation, and relative humidity. The objectives of the current study were to analyse and model the relationships among climate, vector and @entity0 in district of Visakhapatnam, India to understand @entity1 transmission mechanism (MTM). METHODOLOGY: Epidemiological, vector and climate data were analysed for the years 2005 to 2011 in Visakhapatnam to understand the magnitude, trends and seasonal patterns of the @entity0 . Statistical software MINITAB ver. 14 was used for performing correlation, linear and multiple regression analysis. RESULTS/FINDINGS: Perennial @entity0 incidence and mosquito population was observed in the district of Visakhapatnam with peaks in seasons. All the climatic variables have a significant influence on disease incidence as well as on mosquito populations. Correlation coefficient analysis, seasonal index and seasonal analysis demonstrated significant relationships among climatic factors, mosquito population and @entity0 incidence in the district of Visakhapatnam, India. Multiple regression and ARIMA (I) models are best suited models for modeling and prediction of disease incidences and mosquito population. Predicted values of average temperature, mosquito population and malarial cases increased along with the year. Developed MTM algorithm observed a major MTM cycle following the June to August rains and occurring between June to September and minor MTM cycles following March to April rains and occurring between March to April in the district of Visakhapatnam. Fluctuations in climatic factors favored an increase in mosquito populations and thereby increasing the number of malarial cases. Rainfall, temperatures (20  C to 33  C) and humidity (66% to 81%) maintained a warmer, wetter climate for mosquito growth, parasite development and @entity1 transmission. CONCLUSIONS/SIGNIFICANCE: Changes in climatic factors influence @entity1 directly by modifying the behaviour and geographical distribution of vectors and by changing the length of the life cycle of the parasite.

title: Association of Climatic Variability, Vector Population and XXXX in District of Visakhapatnam, India: A Modeling and Prediction Analysis.

answer: @entity0


abstract: Shiga toxin-producing @entity1 (STEC) strains are commonly found in the intestine of ruminant species of wild and domestic animals. Excretion of STEC with animal feces results in a broad contamination of food and the environment. @entity0 get infected with STEC through ingestion of contaminated food, by contact with the environment, and from STEC-excreting animals and @entity0 . STEC strains can behave as @entity0 pathogens, and some of them, called enterohemorrhagic @entity1 (EHEC), may cause @entity2 ( @entity2 ) and @entity3 ( @entity3 ). Because of the diversity of STEC types, detection strategies for STEC and EHEC are based on the identification of Shiga toxins or the underlying genes. Cultural enrichment of STEC from test samples is needed for identification, and different protocols were developed for this purpose. Multiplex real-time PCR protocols ( @entity4 /CEN TS13136 and USDA/FSIS MLG5B.01) have been developed to specifically identify EHEC by targeting the LEE (locus of enterocyte effacement)-encoded eae gene and genes for EHEC-associated O groups. The employment of more genetic markers (nle and CRISPR) is a future challenge for better identification of EHEC from any kinds of samples. The isolation of STEC or EHEC from a sample is required for confirmation, and different cultivation protocols and media for this purpose have been developed. Most STEC strains present in food, animals, and the environment are eae negative, but some of these strains can cause @entity2 and @entity3 in @entity0 as well. Phenotypic assays and molecular tools for typing EHEC and STEC strains are used to detect and characterize @entity0 pathogenic strains among members of the STEC group.

title: Detection of Shiga Toxin-Producing XXXX from Nonhuman Sources and Strain Typing.

answer: @entity1


abstract: UNASSIGNED: Functional divergence between duplicate transcription factors (TFs) has been linked to critical events in the evolution of land plants and can result from changes in patterns of expression, binding site divergence and/or interactions with other proteins. Although plant TFs tend to be retained post polyploidization, many are lost within tens to hundreds of million years. Thus it can be hypothesized that some TFs in plant genomes are in the process of becoming pseudogenes. Here we use a pair of salt tolerance-conferring transcription factors, DWARF AND DELAYED FLOWERING1 ( @entity3 ) and @entity4 , that duplicated through paleopolyploidy 50-65 million years ago, as examples to illustrate potential mechanisms leading to duplicate retention and loss. We found that the expression patterns of @entity0 (At) @entity3 and @entity4 have diverged in a highly asymmetric manner, and @entity4 has lost most inferred ancestral stress responses. Consistent with disablement, the @entity4 promoter has fewer predicted cis-elements and a methylated repetitive element. Through comparisons of @entity3 , @entity4 , and their @entity2 orthologs, we identified significant differences in binding affinities and binding site preference. In particular, an @entity4 -specific substitution within the DNA binding domain significantly reduces binding affinity. Cross-species analyses indicate that both @entity3 and @entity4 are under selective constraint, but among A. thaliana accessions, @entity4 has a higher level of nonsynonymous @entity1 diversity compared to @entity3 . This may be the result of selection in different environments, or may point towards the possibility of ongoing functional decay despite retention for millions of years after gene duplication.

title: Molecular evidence for functional divergence and decay of a transcription factor derived from whole genome duplication in XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity0 with @entity2 are both unique and variable in their presentation and management, often posing a challenge to the pediatrician. Several anatomical and physiologic peculiarities make a @entity0 vulnerable to develop an obstruction of upper airways. The characteristic finding in @entity2 is stridor-inspiratory, biphasic or expiratory. The etiologies vary widely throughout the age groups and according to the mode of presentation. The approach starts with suspicion, mandates careful clinical evaluation of the degree of obstruction and many a times emergency measures precede any investigation or even precise diagnosis. Maintaining an open and stable airway is of the utmost importance, often requiring a team approach of emergency physician, pediatrician, otorhinolaryngologist and pediatric pulmonologist. The commonest condition presenting with @entity2 in pediatric population is viral croup. Croup is a clinical diagnosis in a febrile @entity0 , with barking cough and stridor preceded by upper @entity4 . It is treated with systemic or inhaled @entity1 and nebulized @entity3 . @entity6 and bacterial @entity7 are @entity5 of upper airways, presenting as true airway emergencies. Though the mainstay of therapy is IV antibiotics, the prime concern is maintenance of airway, which frequently requires endotracheal intubation. Rigid bronchoscopy is the procedure of choice for airway foreign bodies, a common cause of @entity2 in @entity0 below 3  y of age. @entity2 are the commonest cause of chronic stridor and are mostly managed conservatively.

title: Upper Airway Obstruction in XXXX .

answer: @entity0


abstract: BACKGROUND: Internet interventions offer advantages that especially @entity1 survivors who suffer from @entity2 could benefit from. Given the growing number of such @entity0 , Internet interventions could supplement and strengthen currently available health care. OBJECTIVE: This paper describes the design and analysis plan that will be used to study 2 Internet interventions aimed at reducing severe @entity2 in @entity1 survivors: a mobile ambulant activity feedback therapy supported through a weekly email by a physiotherapist and a weekly Web- and mindfulness-based cognitive therapy supported online by a psychologist. The data resulting from this trial will be used to (1) investigate the effectiveness, (2) investigate potential mediators of these interventions, and (3) explore @entity0 characteristics that can predict the effect of these interventions. METHODS: A 3-armed randomized controlled trial is proposed that compares both Internet interventions with an active control condition that solely consists of receiving psycho-educational emails. The intervention period is 9 weeks for all 3 conditions. Six months after baseline, @entity0 in the control condition can choose to follow 1 of the 2 experimental Internet interventions. Outcomes are measured in terms of @entity2 severity, mental health, and self-perceived work ability. All are Web-assessed at baseline, 2 weeks after the intervention period, and at 6 and 12 months after baseline. Fatigue severity, mindfulness, physical activity, expectations and credibility of the intervention, therapeutic working alliance, sleep quality, and sense of control over @entity2 are assessed 3 times during the intervention period for identifying mediators of the interventions. Recruitment is performed nationally throughout the Netherlands through @entity0 organizations and their websites, newspapers, and by informing various types of health professionals. All @entity0 register at an open-access website. We aim at including 330 @entity1 survivors who have finished curative-intent @entity1 treatment at least 3 months previously, and have been suffering from severe @entity2 ever since. All @entity1 types are included. A detailed analysis plan is described to address the research questions, which allows for individual variation, and fully exploits the longitudinal design. RESULTS: Recruitment started in April 2013 and will proceed until April 2015. CONCLUSIONS: This paper describes a systematic trial design for studying 2 different interventions for chronic @entity1 in order to gain insight into the effectiveness and mediators of the interventions. This design will also be used to identify predictors for the interventions' effect on @entity2 . By publishing our hypotheses and analysis plan before completion of data collection, this paper is a first step in reporting on this trial comprehensively. TRIAL REGISTRATION: The Netherlands National Trial Register (NTR3483). (Archived by WebCite at http://www.webcitation.org/6NWZqon3o).

title: Effectiveness, Mediators, and Effect Predictors of Internet Interventions for Chronic XXXX : The Design and an Analysis Plan of a 3-Armed Randomized Controlled Trial.

answer: @entity1


abstract: UNASSIGNED: @entity7 , an @entity1 , affects the morphological appearance of the tooth enamel, hair, and bone. Previous studies have confirmed that mutations in the @entity5 gene are responsible for TDO. In this study, we describe a Chinese @entity0 with the typical traits of TDO - kinky hair, @entity3 , skull and jaw bones thickening, and @entity2 . Unfortunately, as a result of @entity6 , we were unable to assess @entity4 . Examination of the tooth ground section showed a thin layer of enamel with no rods on the @entity0 's tooth and abnormalities in Tomes' granular layer and the dentinal tubules. Scanning electron microscopy and energy-dispersive X-ray spectroscopy of the tooth enamel showed significant differences between the @entity0 and the control individuals. A hair sample from the @entity0 observed under a laser-scanning microscope showed longitudinal grooves in the hair shaft. Dual-energy X-ray absorptiometry measurement showed that the bone mineral density values of the @entity0 's bones was much higher than normal. Finally, genetic analysis revealed a novel de novo missense mutation @entity8 ( @entity9 ) in the conserved homeodomain of the @entity5 gene. This @entity5 mutation is the sixth causative mutation for TDO to be identified so far.

title: Morphological analyses and a novel de novo XXXX mutation associated with @entity7 in a Chinese family.

answer: @entity5


abstract: UNASSIGNED: @entity7 , an @entity1 , affects the morphological appearance of the tooth enamel, hair, and bone. Previous studies have confirmed that mutations in the @entity5 gene are responsible for TDO. In this study, we describe a Chinese @entity0 with the typical traits of TDO - kinky hair, @entity3 , skull and jaw bones thickening, and @entity2 . Unfortunately, as a result of @entity6 , we were unable to assess @entity4 . Examination of the tooth ground section showed a thin layer of enamel with no rods on the @entity0 's tooth and abnormalities in Tomes' granular layer and the dentinal tubules. Scanning electron microscopy and energy-dispersive X-ray spectroscopy of the tooth enamel showed significant differences between the @entity0 and the control individuals. A hair sample from the @entity0 observed under a laser-scanning microscope showed longitudinal grooves in the hair shaft. Dual-energy X-ray absorptiometry measurement showed that the bone mineral density values of the @entity0 's bones was much higher than normal. Finally, genetic analysis revealed a novel de novo missense mutation @entity8 ( @entity9 ) in the conserved homeodomain of the @entity5 gene. This @entity5 mutation is the sixth causative mutation for TDO to be identified so far.

title: Morphological analyses and a novel de novo @entity5 mutation associated with XXXX in a Chinese family.

answer: @entity7