abstract: BACKGROUND CONTEXT: @entity4 ( @entity4 ) is a progressive @entity3 . @entity0 with @entity4 often present with abnormal posturing. PURPOSE: To investigate coronal @entity1 in @entity0 with @entity4 , and to evaluate the correlation between clinical features, coronal parameters related to spine alignment, and disease severity. STUDY DESIGN: A cross-sectional study. @entity0 SAMPLE: Eighty-nine @entity0 with @entity4 and 89 controls were included. OUTCOME MEASURES: A medical history was collected from the medical records. METHODS: This study was a prospective assessment of consecutive @entity0 with @entity4 . Clinical and demographic parameters were collected from medical records and outpatient interviews. Full-length standing anteroposterior and lateral spine radiographs were used to assess the spinal parameters. The threshold for @entity6 was set at a 10   Cobb angle, and the curve type was classified using Schwab classification. RESULTS: A total of 178 @entity0 (89 in @entity4 and 89 in control groups) were included. @entity6 was identified in 27 @entity0 (30%) and 22 controls (p=.502). However, coronal imbalance was more common in @entity0 with @entity4 than in controls (11 vs. 0 @entity0 , p=.001). @entity6 was more common in @entity0 than in @entity0 (male:female=8:19, p=.04). Back @entity2 was more common in @entity0 with @entity6 than in those without @entity6 (14 of 27 vs. 17 of 62, p=.036). Schwab Type IV (thoracolumbar major) was the most common type of @entity6 in @entity0 with @entity4 and Type V (lumbar major) was the most common type in controls. With adjustment for @entity0 age and gender, multiple linear regression analysis revealed that severity of @entity4 (Unified @entity4 Rating Scale, p=.037) and magnitude of global @entity5 (p=.003) were associated with the @entity6 Cobb angle (p=.037, B=0.139). Direction of @entity6 and side of global @entity5 were not significantly correlated with the laterality of predominant @entity4 symptoms (p>.05). CONCLUSIONS: Global @entity5 is more prevalent in @entity0 with @entity4 than in controls. Greater severity of @entity4 was significantly associated with greater magnitude of @entity6 Cobb angle, even after adjusting for the effects of @entity0 age and gender. However, direction of @entity6 and side of global @entity5 were not significantly associated with the dominant laterality of @entity4 symptoms.

title: XXXX and @entity4 : prevalence and associations with disease severity.

answer: @entity5


abstract: BACKGROUND CONTEXT: @entity4 ( @entity4 ) is a progressive @entity3 . @entity0 with @entity4 often present with abnormal posturing. PURPOSE: To investigate coronal @entity1 in @entity0 with @entity4 , and to evaluate the correlation between clinical features, coronal parameters related to spine alignment, and disease severity. STUDY DESIGN: A cross-sectional study. @entity0 SAMPLE: Eighty-nine @entity0 with @entity4 and 89 controls were included. OUTCOME MEASURES: A medical history was collected from the medical records. METHODS: This study was a prospective assessment of consecutive @entity0 with @entity4 . Clinical and demographic parameters were collected from medical records and outpatient interviews. Full-length standing anteroposterior and lateral spine radiographs were used to assess the spinal parameters. The threshold for @entity6 was set at a 10   Cobb angle, and the curve type was classified using Schwab classification. RESULTS: A total of 178 @entity0 (89 in @entity4 and 89 in control groups) were included. @entity6 was identified in 27 @entity0 (30%) and 22 controls (p=.502). However, coronal imbalance was more common in @entity0 with @entity4 than in controls (11 vs. 0 @entity0 , p=.001). @entity6 was more common in @entity0 than in @entity0 (male:female=8:19, p=.04). Back @entity2 was more common in @entity0 with @entity6 than in those without @entity6 (14 of 27 vs. 17 of 62, p=.036). Schwab Type IV (thoracolumbar major) was the most common type of @entity6 in @entity0 with @entity4 and Type V (lumbar major) was the most common type in controls. With adjustment for @entity0 age and gender, multiple linear regression analysis revealed that severity of @entity4 (Unified @entity4 Rating Scale, p=.037) and magnitude of global @entity5 (p=.003) were associated with the @entity6 Cobb angle (p=.037, B=0.139). Direction of @entity6 and side of global @entity5 were not significantly correlated with the laterality of predominant @entity4 symptoms (p>.05). CONCLUSIONS: Global @entity5 is more prevalent in @entity0 with @entity4 than in controls. Greater severity of @entity4 was significantly associated with greater magnitude of @entity6 Cobb angle, even after adjusting for the effects of @entity0 age and gender. However, direction of @entity6 and side of global @entity5 were not significantly associated with the dominant laterality of @entity4 symptoms.

title: @entity5 and XXXX : prevalence and associations with disease severity.

answer: @entity4


abstract: AIM: To review our outcomes and compare the results of the @entity1 ( @entity1 ) to other implants for @entity3 management at a regional Australian hospital. METHODS: The @entity1 is a novel implant for the management of @entity3 . It is, however, technically demanding and treatment results have not yet been assessed outside tertiary centres. Twenty-seven @entity0 with 28 @entity3 who had been managed surgically at the Mackay Base Hospital from January 2004 to December 2010 were retrospectively enrolled and assessed clinically and radiologically. Outcomes were union, @entity2 , Lysholm score, knee range of motion, and complication rates. RESULTS: Twenty @entity3 were managed with the @entity1 and eight @entity3 were managed with alternative implants. Analysis of the surgical techniques revealed that 11 @entity3 managed with the @entity1 were performed according to the recommended principles ( @entity1 -R) and 9 were not ( @entity1 -N). Union occurred in 67.9% of @entity3 overall: 9/11 (82%) in the @entity1 -R group vs 5/9 (56%) in the @entity1 -N group and 5/8 (62.5%) in the alternative implant group. There was no statistically significant difference between @entity2 , Lysholm score, and complication rates between the groups. However, there was a trend towards the @entity1 -R group having superior outcomes which were clinically significant. There was a statistically significant greater range of median knee flexion in the @entity1 -R group with compared to the @entity1 -N group (P = 0.0143) and compared with the alternative implant group (P = 0.0454). CONCLUSION: The trends towards the benefits of the @entity1 procedure when correctly applied would suggest that not only should the @entity1 procedure be performed for @entity3 , but the correct principle of insertion is important in improving the @entity0 's outcome.

title: Treatment of XXXX in a regional Australian hospital.

answer: @entity3


abstract: OBJECTIVE: To establish the utility of @entity4 (PCT) and other clinical and analytical parameters as markers of acute and permanent @entity1 in @entity0 after a first febrile urinary tract infection (UTI). METHODS: Retrospective multicentre study. Statistical study: descriptive, receiver operating characteristic (ROC) curves and multiple logistic regression. RESULTS: 219 @entity0 , aged between 1 week and 14 years (68% under 1 year). The mean PCT values were significantly higher in @entity0 with acute @entity5 with respect to normal acute @entity6 (4.8 vs 1.44; p=0.0001), without achieving that signification for late affected @entity6 (6.5 vs 5.05; p=0.6). The area under the ROC curve for PCT was 0.64 (CI 95% 0.55-0.72) for @entity3 , and 0.62 (CI 95% 0.44-0.80) for permanent damage, with optimum statistical cut-off values of 0.85 and 1.17ng/ml. Multivariate analysis for @entity3 only found correlation with PCT (Odds Ratio [OR] 1.2 (CI 95% 1.06-1.4, p=0.005), and hours of @entity2 (OR for less than 6 hours of @entity2 0.4 (CI 95% 0.2-1.02, p=0.05). In @entity0 with @entity1 , PCT showed an OR 1.0 (CI 95% 0.9-1.1, p=0.6). CONCLUSIONS: PCT and the duration of @entity2 were the only parameters statistically associated with early @entity1 did not reach statistical significance.

title: Predictive factors for XXXX in febrile urinary tract infection. Usefulness of @entity4 .

answer: @entity1


abstract: OBJECTIVE: To establish the utility of @entity4 (PCT) and other clinical and analytical parameters as markers of acute and permanent @entity1 in @entity0 after a first febrile urinary tract infection (UTI). METHODS: Retrospective multicentre study. Statistical study: descriptive, receiver operating characteristic (ROC) curves and multiple logistic regression. RESULTS: 219 @entity0 , aged between 1 week and 14 years (68% under 1 year). The mean PCT values were significantly higher in @entity0 with acute @entity5 with respect to normal acute @entity6 (4.8 vs 1.44; p=0.0001), without achieving that signification for late affected @entity6 (6.5 vs 5.05; p=0.6). The area under the ROC curve for PCT was 0.64 (CI 95% 0.55-0.72) for @entity3 , and 0.62 (CI 95% 0.44-0.80) for permanent damage, with optimum statistical cut-off values of 0.85 and 1.17ng/ml. Multivariate analysis for @entity3 only found correlation with PCT (Odds Ratio [OR] 1.2 (CI 95% 1.06-1.4, p=0.005), and hours of @entity2 (OR for less than 6 hours of @entity2 0.4 (CI 95% 0.2-1.02, p=0.05). In @entity0 with @entity1 , PCT showed an OR 1.0 (CI 95% 0.9-1.1, p=0.6). CONCLUSIONS: PCT and the duration of @entity2 were the only parameters statistically associated with early @entity1 did not reach statistical significance.

title: Predictive factors for @entity1 in febrile urinary tract infection. Usefulness of XXXX .

answer: @entity4


abstract: Data on the effectiveness of implantable @entity3 ( @entity3 ) with respect to reducing mortality in @entity0 with @entity4 ( @entity4 ) and @entity1 ( @entity1 ) are lacking. The purpose of this meta-analysis was to compare the mortality of @entity0 with @entity1 who have received and not received an @entity6 . A search was conducted on January 31, 2013 of Medline, Cochrane, EMBASE, and Google Scholar. Studies were selected for inclusion based on the following criteria. 1) Randomized controlled trial. 2) @entity1 @entity0 with @entity2 . 3) Device therapy ( @entity6 , CRT-defibrillator [CRT-D]) used to treat @entity2 . 4) Primary outcome is survival analysis. 5) Retrospective study if survival analysis was performed. The primary outcome was @entity5 ( @entity5 ), and the secondary outcome was 2-year survival. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated, and a   2-based test of homogeneity was performed. Three studies were included in the analysis. The combined OR for @entity5 was 2.245 (95% CI 1.871 to 2.685, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher @entity5 than those without an @entity6 . The combined OR for 2-year survival was 2.312 (95% CI 1.921 to 2.784, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher 2-year survival rate than those without an @entity6 . The use of @entity6 in @entity0 with @entity1 is associated with an increase in the @entity5 and the 2-year survival rate.

title: A meta-analysis of mortality in XXXX @entity0 receiving @entity3 ( @entity3 ).

answer: @entity1


abstract: Data on the effectiveness of implantable @entity3 ( @entity3 ) with respect to reducing mortality in @entity0 with @entity4 ( @entity4 ) and @entity1 ( @entity1 ) are lacking. The purpose of this meta-analysis was to compare the mortality of @entity0 with @entity1 who have received and not received an @entity6 . A search was conducted on January 31, 2013 of Medline, Cochrane, EMBASE, and Google Scholar. Studies were selected for inclusion based on the following criteria. 1) Randomized controlled trial. 2) @entity1 @entity0 with @entity2 . 3) Device therapy ( @entity6 , CRT-defibrillator [CRT-D]) used to treat @entity2 . 4) Primary outcome is survival analysis. 5) Retrospective study if survival analysis was performed. The primary outcome was @entity5 ( @entity5 ), and the secondary outcome was 2-year survival. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated, and a   2-based test of homogeneity was performed. Three studies were included in the analysis. The combined OR for @entity5 was 2.245 (95% CI 1.871 to 2.685, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher @entity5 than those without an @entity6 . The combined OR for 2-year survival was 2.312 (95% CI 1.921 to 2.784, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher 2-year survival rate than those without an @entity6 . The use of @entity6 in @entity0 with @entity1 is associated with an increase in the @entity5 and the 2-year survival rate.

title: A meta-analysis of mortality in @entity1 @entity0 receiving XXXX ( @entity3 ).

answer: @entity3


abstract: Data on the effectiveness of implantable @entity3 ( @entity3 ) with respect to reducing mortality in @entity0 with @entity4 ( @entity4 ) and @entity1 ( @entity1 ) are lacking. The purpose of this meta-analysis was to compare the mortality of @entity0 with @entity1 who have received and not received an @entity6 . A search was conducted on January 31, 2013 of Medline, Cochrane, EMBASE, and Google Scholar. Studies were selected for inclusion based on the following criteria. 1) Randomized controlled trial. 2) @entity1 @entity0 with @entity2 . 3) Device therapy ( @entity6 , CRT-defibrillator [CRT-D]) used to treat @entity2 . 4) Primary outcome is survival analysis. 5) Retrospective study if survival analysis was performed. The primary outcome was @entity5 ( @entity5 ), and the secondary outcome was 2-year survival. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated, and a   2-based test of homogeneity was performed. Three studies were included in the analysis. The combined OR for @entity5 was 2.245 (95% CI 1.871 to 2.685, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher @entity5 than those without an @entity6 . The combined OR for 2-year survival was 2.312 (95% CI 1.921 to 2.784, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher 2-year survival rate than those without an @entity6 . The use of @entity6 in @entity0 with @entity1 is associated with an increase in the @entity5 and the 2-year survival rate.

title: A meta-analysis of mortality in @entity1 @entity0 receiving @entity3 ( XXXX ).

answer: @entity3


abstract: Data on the effectiveness of implantable @entity3 ( @entity3 ) with respect to reducing mortality in @entity0 with @entity4 ( @entity4 ) and @entity1 ( @entity1 ) are lacking. The purpose of this meta-analysis was to compare the mortality of @entity0 with @entity1 who have received and not received an @entity6 . A search was conducted on January 31, 2013 of Medline, Cochrane, EMBASE, and Google Scholar. Studies were selected for inclusion based on the following criteria. 1) Randomized controlled trial. 2) @entity1 @entity0 with @entity2 . 3) Device therapy ( @entity6 , CRT-defibrillator [CRT-D]) used to treat @entity2 . 4) Primary outcome is survival analysis. 5) Retrospective study if survival analysis was performed. The primary outcome was @entity5 ( @entity5 ), and the secondary outcome was 2-year survival. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated, and a   2-based test of homogeneity was performed. Three studies were included in the analysis. The combined OR for @entity5 was 2.245 (95% CI 1.871 to 2.685, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher @entity5 than those without an @entity6 . The combined OR for 2-year survival was 2.312 (95% CI 1.921 to 2.784, P<0.001), indicating that @entity0 with an @entity6 had a significantly higher 2-year survival rate than those without an @entity6 . The use of @entity6 in @entity0 with @entity1 is associated with an increase in the @entity5 and the 2-year survival rate.

title: A meta-analysis of mortality in @entity1 XXXX receiving @entity3 ( @entity3 ).

answer: @entity0


abstract: @entity0 and apoptosis play critical roles in the acute progression of @entity2 pathology. Emerging evidence indicates that vagus nerve stimulation (VNS) following focal @entity8 and reperfusion (I/R) may be neuroprotective by limiting @entity5 size. However, the underlying molecular mechanisms remain unclear. In this study, we investigated whether the protective effects of VNS in acute cerebral I/R injury were associated with anti-inflammatory and anti-apoptotic processes. Male Sprague-Dawley (SD) @entity1 underwent VNS at 30 min after focal cerebral I/R surgery. Twenty-four h after reperfusion, neurological deficit scores, @entity5 volume, and neuronal apoptosis were evaluated. In addition, the levels of pro-inflammatory cytokines were detected using enzyme-linked immune sorbent assay (ELISA), and immunofluorescence staining for the endogenous "cholinergic anti-inflammatory pathway" was also performed. The protein expression of a7 nicotinic @entity4 receptor (a7nAchR), phosphorylated @entity7 (p- @entity7 ), and cleaved caspase 3 in @entity2 penumbra were determined with Western blot analysis. I/ @entity9 treated with VNS (I/R+VNS) had significantly better neurological deficit scores, reduced @entity3 , and decreased number of TdT mediated @entity6 nick end labeling (TUNEL) positive cells. Furthermore, in the @entity2 penumbra of the I/R+VNS group, the levels of pro-inflammatory cytokines and cleaved caspase 3 protein were significantly decreased, and the levels of a7nAchR and phosphorylated @entity7 were significantly increased relative to the I/R alone group. These results indicate that VNS is neuroprotective in acute cerebral I/R injury by suppressing @entity0 and apoptosis via activation of cholinergic and a7nAchR/ @entity7 pathways.

title: Vagus nerve stimulation attenuates XXXX and reperfusion injury via endogenous cholinergic pathway in @entity1 .

answer: @entity8


abstract: @entity0 and apoptosis play critical roles in the acute progression of @entity2 pathology. Emerging evidence indicates that vagus nerve stimulation (VNS) following focal @entity8 and reperfusion (I/R) may be neuroprotective by limiting @entity5 size. However, the underlying molecular mechanisms remain unclear. In this study, we investigated whether the protective effects of VNS in acute cerebral I/R injury were associated with anti-inflammatory and anti-apoptotic processes. Male Sprague-Dawley (SD) @entity1 underwent VNS at 30 min after focal cerebral I/R surgery. Twenty-four h after reperfusion, neurological deficit scores, @entity5 volume, and neuronal apoptosis were evaluated. In addition, the levels of pro-inflammatory cytokines were detected using enzyme-linked immune sorbent assay (ELISA), and immunofluorescence staining for the endogenous "cholinergic anti-inflammatory pathway" was also performed. The protein expression of a7 nicotinic @entity4 receptor (a7nAchR), phosphorylated @entity7 (p- @entity7 ), and cleaved caspase 3 in @entity2 penumbra were determined with Western blot analysis. I/ @entity9 treated with VNS (I/R+VNS) had significantly better neurological deficit scores, reduced @entity3 , and decreased number of TdT mediated @entity6 nick end labeling (TUNEL) positive cells. Furthermore, in the @entity2 penumbra of the I/R+VNS group, the levels of pro-inflammatory cytokines and cleaved caspase 3 protein were significantly decreased, and the levels of a7nAchR and phosphorylated @entity7 were significantly increased relative to the I/R alone group. These results indicate that VNS is neuroprotective in acute cerebral I/R injury by suppressing @entity0 and apoptosis via activation of cholinergic and a7nAchR/ @entity7 pathways.

title: Vagus nerve stimulation attenuates @entity8 and reperfusion injury via endogenous cholinergic pathway in XXXX .

answer: @entity1


abstract: OBJECTIVE: The relationship between silent @entity1 (SNI) and arterial stiffness assessed by cardio-ankle vascular index (CAVI) has not been evaluated in @entity0 treated with coronary angiography and intervention due to @entity2 ( @entity2 ). The aim of this study is to evaluate the value of CAVI in prediction of SNI after percutaneous coronary angiography and intervention in @entity0 presented with @entity2 . METHODS: Eighty-three consecutive @entity0 presented with @entity2 , who underwent percutaneous coronary angiography and intervention, were included in this prospective observational study on diagnostic accuracy. @entity3 ( @entity3 ) was studied before and 18 hour after the coronary angiography and intervention. CAVI was measured by VaSera-1000 instrument. Clinical and echocardiographic characteristics were analyzed and independent predictors of SNI were evaluated. Chi-square, Student t-test, Mann-Whithney U test, correlation analysis and logistic regression analysis was used for statistical analysis. RESULTS: @entity3 levels significantly increased after cardiac catheterization (9.82  3.22 mg/dL vs. 13.15  8.55 mg/dL, p<0.001). CAVI (OR=2.992, 95% CI: 1.494-5.713, p=0.002), left ventricular ejection fraction (LVEF) (OR=0.911, 95% CI: 0.843-0.983, p=0.017) and undergoing percutaneous coronary intervention (OR=4.430, 95% CI: 1.034-18.97, p=0.045) were the independent predictors of SNI in logistic regression analysis. The cut-off value to show SNI for CAVI was 10.45 (sensitivity=71.8%, specificity=91.5%) in receiver operator charecteristic receiver operator charecteristic (ROC) curve analysis. The area under curve was 0.832 (95% CI=0.746-0.918, p<0.001). CONCLUSION: Besides undergoing PCI and having LVEF, measurement of CAVI may be a useful tool for predicting the development of SNI after percutaneous coronary angiography and intervention in @entity0 with @entity2 .

title: Cardio-ankle vascular index may be an important marker of silent XXXX after percutaneous coronary angiography and intervention: a prospective observational study on diagnostic accuracy.

answer: @entity1


abstract: There is increasing interest in the role of T follicular helper (Tfh) cells in autoimmunity from the perspective of both their role in breach of tolerance and their effects on the natural history of disease progression. Indeed, the critical role of Tfh cells in autoimmunity is further highlighted based on their location in the germinal center (GC), a pathogenic hot spot for development of autoreactivity. To address the role of Tfh cells in primary biliary cirrhosis (PBC), we comprehensively evaluated the immunobiology of @entity4 (+) @entity1 (+) Tfh cells in 69 @entity0 with PBC, including a nested subgroup of 16 autoimmune hepatitis (AIH) and 20 healthy controls (HC), followed for 1 year. We report herein several key observations. First, there was an increased frequency of circulating Tfh cells in @entity0 with PBC compared to AIH (P < 0.05) and HC (P < 0.01). Second, the function of circulating Tfh cells from PBC @entity0 , including interleukin (IL)-21 production (P < 0.05), the ability to promote B-cell maturation, and autoantibody production, were greater than HC. Third, the frequency of these cells was significantly decreased in @entity2 ( @entity3 ) responders compared to @entity3 -treated nonresponders, in both cross-sectional (P = 0.023) and longitudinal studies (P = 0.036), respectively. Indeed, similar increases of Tfh cells were noted in liver and spleen. CONCLUSION: These results significantly extend our understanding of lymphoid subpopulations in PBC and their relative role in disease expression. Our data also provide a novel biomarker for evaluation of the effectiveness of new therapeutic approaches.

title: XXXX + @entity1 + T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis.

answer: @entity4


abstract: There is increasing interest in the role of T follicular helper (Tfh) cells in autoimmunity from the perspective of both their role in breach of tolerance and their effects on the natural history of disease progression. Indeed, the critical role of Tfh cells in autoimmunity is further highlighted based on their location in the germinal center (GC), a pathogenic hot spot for development of autoreactivity. To address the role of Tfh cells in primary biliary cirrhosis (PBC), we comprehensively evaluated the immunobiology of @entity4 (+) @entity1 (+) Tfh cells in 69 @entity0 with PBC, including a nested subgroup of 16 autoimmune hepatitis (AIH) and 20 healthy controls (HC), followed for 1 year. We report herein several key observations. First, there was an increased frequency of circulating Tfh cells in @entity0 with PBC compared to AIH (P < 0.05) and HC (P < 0.01). Second, the function of circulating Tfh cells from PBC @entity0 , including interleukin (IL)-21 production (P < 0.05), the ability to promote B-cell maturation, and autoantibody production, were greater than HC. Third, the frequency of these cells was significantly decreased in @entity2 ( @entity3 ) responders compared to @entity3 -treated nonresponders, in both cross-sectional (P = 0.023) and longitudinal studies (P = 0.036), respectively. Indeed, similar increases of Tfh cells were noted in liver and spleen. CONCLUSION: These results significantly extend our understanding of lymphoid subpopulations in PBC and their relative role in disease expression. Our data also provide a novel biomarker for evaluation of the effectiveness of new therapeutic approaches.

title: @entity4 + XXXX + T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: In @entity0 with space-occupying @entity3 , surgical decompression strongly reduces risk of death and increases the chance of a favorable outcome. This comes at the expense of an increase in the risk of survival with (moderately) severe disability. We assessed quality of life, @entity1 , and caregiver burden in these @entity0 . SUMMARY OF REVIEW: We systematically reviewed the literature by searching MEDLINE, EMBASE, and PsycINFO up to March 2014. We included randomized controlled trials, cohort studies, case-control studies, and case series with quality of life, @entity1 , or caregiver burden as primary or secondary outcome. Seventeen articles reporting on 459 @entity0 were included. At final follow-up at 7 to 51 months, 1344 @entity0 (30%) had died, and 34 (11%) were lost to follow up. Data on 291 @entity0 were available, of whom 81 of 213 survivors (39%) achieved good functional outcome at final follow-up (modified Rankin Scale  <=3). Mean quality of life was 46% to 67% of the best possible score when based on questionnaires or visual analogue scales. At final follow-up, 143 of 189 @entity0 (76%) would in retrospect again choose for surgical decompression. Severe @entity1 were present in 14 of 113 @entity0 (16%). Three studies investigated caregiver burden and reported substantial burden. @entity0 more than 60 years old had a lower quality of life in comparison with younger @entity0 . CONCLUSIONS: Most @entity0 treated with surgical decompression for space-occupying @entity2 have a reasonable quality of life at long-term follow-up and are satisfied with the treatment received. Severe @entity1 are uncommon.

title: Quality of life after surgical decompression for space-occupying XXXX : Systematic review.

answer: @entity3


abstract: BACKGROUND: Shoulder @entity1 and @entity2 after neck dissection may result from @entity3 . The effect of early physical therapy in the form of intensive scapular strengthening exercises is unknown. METHODS: A total of 59 neck dissection @entity0 were prospectively recruited for this study. @entity0 were randomly assigned to either the intervention group (n = 32), consisting of progressive scapular strengthening exercises for 12 weeks, or the control group (n = 29). Blinded assessment occurred at baseline, and at 3, 6, and 12 months. RESULTS: Three-month data were collected on 52 @entity0 /53 shoulders. Per-protocol analysis demonstrated that the intervention group had statistically significantly higher active shoulder abduction at 3 months compared to the control group (+26.6  ; 95% confidence interval [CI] 7.28-45.95; p = .007). CONCLUSION: The intervention is a favorable treatment for maximizing shoulder abduction in the short term. The effect of the intervention compared to usual care is uncertain in the longer term.    2014 Wiley Periodicals, Inc. Head Neck 37: 1022-1031, 2015.

title: Maximizing shoulder function after XXXX and neck dissection surgery: A multicenter randomized controlled trial.

answer: @entity3


abstract: @entity5 is the most frequent type of @entity4 . Recently, attention has been focused in the expression of angiogenic factors by these @entity1 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity0 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity5 were studied. Clinical and pathological data were collected. @entity1 were studied to assess immunohistochemical expression of the following markers: @entity2 , @entity7 , @entity6 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7 was directly related to Furhman grade, invasion of the renal vein and @entity1 stage. Likewise, @entity1 proliferation index, assessed with Ki67, was directly related to the presence of @entity3 , capsular invasion and advanced @entity1 stage. Regarding the expression of @entity6 , vascular density was inversely related to @entity1 @entity3 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity1 evolution and prognostic evaluation of these @entity1 .

title: Expression of @entity2 , @entity7 , @entity6 and Ki67 in XXXX and their relationship with conventional prognostic markers.

answer: @entity5


abstract: @entity5 is the most frequent type of @entity4 . Recently, attention has been focused in the expression of angiogenic factors by these @entity1 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity0 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity5 were studied. Clinical and pathological data were collected. @entity1 were studied to assess immunohistochemical expression of the following markers: @entity2 , @entity7 , @entity6 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7 was directly related to Furhman grade, invasion of the renal vein and @entity1 stage. Likewise, @entity1 proliferation index, assessed with Ki67, was directly related to the presence of @entity3 , capsular invasion and advanced @entity1 stage. Regarding the expression of @entity6 , vascular density was inversely related to @entity1 @entity3 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity1 evolution and prognostic evaluation of these @entity1 .

title: Expression of XXXX , @entity7 , @entity6 and Ki67 in @entity5 and their relationship with conventional prognostic markers.

answer: @entity2


abstract: @entity5 is the most frequent type of @entity4 . Recently, attention has been focused in the expression of angiogenic factors by these @entity1 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity0 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity5 were studied. Clinical and pathological data were collected. @entity1 were studied to assess immunohistochemical expression of the following markers: @entity2 , @entity7 , @entity6 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7 was directly related to Furhman grade, invasion of the renal vein and @entity1 stage. Likewise, @entity1 proliferation index, assessed with Ki67, was directly related to the presence of @entity3 , capsular invasion and advanced @entity1 stage. Regarding the expression of @entity6 , vascular density was inversely related to @entity1 @entity3 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity1 evolution and prognostic evaluation of these @entity1 .

title: Expression of @entity2 , @entity7 , XXXX and Ki67 in @entity5 and their relationship with conventional prognostic markers.

answer: @entity6


abstract: @entity5 is the most frequent type of @entity4 . Recently, attention has been focused in the expression of angiogenic factors by these @entity1 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity0 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity5 were studied. Clinical and pathological data were collected. @entity1 were studied to assess immunohistochemical expression of the following markers: @entity2 , @entity7 , @entity6 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7 was directly related to Furhman grade, invasion of the renal vein and @entity1 stage. Likewise, @entity1 proliferation index, assessed with Ki67, was directly related to the presence of @entity3 , capsular invasion and advanced @entity1 stage. Regarding the expression of @entity6 , vascular density was inversely related to @entity1 @entity3 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity1 evolution and prognostic evaluation of these @entity1 .

title: Expression of @entity2 , XXXX , @entity6 and Ki67 in @entity5 and their relationship with conventional prognostic markers.

answer: @entity7


abstract: BACKGROUND: Pulsed dye laser (PDL) treatments have been suggested to be a safe and effective therapeutic approach for treating @entity3 ( @entity3 ). However, robust supporting evidence is lacking due to inconsistent design of available studies. OBJECTIVES: To evaluate PDL efficacy and safety in treating superficial BCC (sBCC) at low-risk anatomical sites in an evidence-based study setting. MATERIALS AND METHODS: Thirty-nine @entity0 (27 @entity0 and 12 @entity0 , 75  9      10  years) with a total of 100 sBCCs were randomized to receive PDL treatment (wavelength 595  nm; fluence 8  J  cm(-2) ; pulse duration 0  5  ms; spot size 10  mm) or sham treatment. The primary endpoint was complete clinical and histological remission of the @entity1 at 6-month follow-up; the secondary endpoints were the evaluation of side-effects and @entity2 as well as @entity0 satisfaction. RESULTS: The primary endpoint showed significant superiority of the laser group to the sham group (P  <  0  0001). Complete remission was achieved in 44 of 56 cases (78  6%) in the laser and in two of 44 cases (4  5%) in the sham treatment arm. The main adverse events in the laser group were crusts, @entity4 . An average of 72% of @entity0 stated at the individual sessions that they were 'satisfied' with the laser treatment, whereas 25% were 'very satisfied'. CONCLUSIONS: PDL is an effective and safe method for treating sBCC. However, the occurrence of persistent dyspigmentation still limits the potential for excellent cosmetic outcomes.

title: The role of the 595-nm pulsed dye laser in treating XXXX : outcome of a double-blind randomized placebo-controlled trial.

answer: @entity3


abstract: Clinically evident @entity4 involving the heart has been noted in at least 2 to 7% of @entity0 with @entity4 , but occult involvement is much higher (> 20%). @entity3 is often not recognized antemortem, as @entity8 may be the presenting feature. Cardiac involvement may occur at any point during the course of @entity4 and may occur in the absence of pulmonary or systemic involvement. @entity4 can involve any part of the heart, with protean manifestations. Prognosis of @entity3 is related to extent and site(s) of involvement. Most deaths due to @entity3 are due to @entity7 or @entity11 , but granulomatous infiltration of the myocardium may be lethal. The definitive diagnosis of isolated @entity3 is difficult. The yield of endomyocardial biopsies is low; treatment of @entity3 is often warranted even in the absence of histologic proof. Radionuclide scans are integral to the diagnosis. Currently, @entity5 positron emission tomography/computed tomography and @entity10 -enhanced magnetic resonance imaging scans are the key imaging modalities to diagnose @entity3 . The prognosis of @entity3 is variable, but mortality rates of untreated @entity3 are high. Although randomized therapeutic trials have not been done, @entity1 (alone or combined with additional immunosuppressive medications) remain the mainstay of treatment. Because of the potential for @entity9 , implantable cardioverter-defibrillators should be placed in any @entity0 with @entity3 and serious @entity7 or @entity6 , and should be considered for @entity2 . Cardiac transplantation is a viable option for @entity0 with end-stage @entity3 refractory to medical therapy.

title: Cardiac involvement in XXXX : evolving concepts in diagnosis and treatment.

answer: @entity4


abstract: BACKGROUND: Several different methods have been used to assess pulmonary permeability in response to @entity1 ( @entity1 ). However, these methods often involve complicated procedures and algorithms that are difficult to precisely control. The purpose of the current study is to establish a feasible method to evaluate alterations in lung permeability by instilling fluorescently labeled dextran ( @entity2 -Dextran) intranasally. METHODS/PRINCIPAL FINDINGS: For the @entity0 model of direct @entity1 , lipopolysaccharide (LPS) was administered intranasally. @entity2 -Dextran was instilled intranasally one hour before the @entity0 were euthanized. Plasma fluorescence intensities from the LPS group were significantly higher than in the control group. To determine the reliability and reproducibility of the procedure, we also measured the lung wet-to-dry weight ratio, the protein concentration of the bronchoalveolar lavage fluid, tight and adherens junction markers and pathological changes. Consistent results were observed when the LPS group was compared with the control group. Simultaneously, we found that the concentration of plasma @entity2 -Dextran was LPS dose-dependent. The concentration of plasma @entity2 -Dextran also increased with initial intranasal @entity2 -Dextran doses. Furthermore, increased fluorescence intensity of plasma @entity2 -Dextran was found in the intraperitoneally LPS-induced @entity1 model. CONCLUSION/SIGNIFICANCE: In conclusion, the measurement of @entity2 -Dextran in plasma after intranasal instillation is a simple, reliable, and reproducible method to evaluate lung permeability alterations in vivo. The concentration of @entity2 -Dextran in the plasma may be useful as a potential peripheral biomarker of @entity1 in experimental clinical studies.

title: Pulmonary permeability assessed by fluorescent-labeled dextran instilled intranasally into @entity0 with LPS-induced XXXX .

answer: @entity1


abstract: BACKGROUND: Several different methods have been used to assess pulmonary permeability in response to @entity1 ( @entity1 ). However, these methods often involve complicated procedures and algorithms that are difficult to precisely control. The purpose of the current study is to establish a feasible method to evaluate alterations in lung permeability by instilling fluorescently labeled dextran ( @entity2 -Dextran) intranasally. METHODS/PRINCIPAL FINDINGS: For the @entity0 model of direct @entity1 , lipopolysaccharide (LPS) was administered intranasally. @entity2 -Dextran was instilled intranasally one hour before the @entity0 were euthanized. Plasma fluorescence intensities from the LPS group were significantly higher than in the control group. To determine the reliability and reproducibility of the procedure, we also measured the lung wet-to-dry weight ratio, the protein concentration of the bronchoalveolar lavage fluid, tight and adherens junction markers and pathological changes. Consistent results were observed when the LPS group was compared with the control group. Simultaneously, we found that the concentration of plasma @entity2 -Dextran was LPS dose-dependent. The concentration of plasma @entity2 -Dextran also increased with initial intranasal @entity2 -Dextran doses. Furthermore, increased fluorescence intensity of plasma @entity2 -Dextran was found in the intraperitoneally LPS-induced @entity1 model. CONCLUSION/SIGNIFICANCE: In conclusion, the measurement of @entity2 -Dextran in plasma after intranasal instillation is a simple, reliable, and reproducible method to evaluate lung permeability alterations in vivo. The concentration of @entity2 -Dextran in the plasma may be useful as a potential peripheral biomarker of @entity1 in experimental clinical studies.

title: Pulmonary permeability assessed by fluorescent-labeled dextran instilled intranasally into XXXX with LPS-induced @entity1 .

answer: @entity0


abstract: BACKGROUND: Treatment of @entity1 has been studied, but treatment strategies and outcomes have not been reported for a large community-based group of @entity0 . OBJECTIVE: We sought to determine the treatments most commonly prescribed and the performance of all systemic and surgical treatments used in @entity1 @entity0 in Olmsted County, Minnesota, treated over a 40-year period. METHODS: A retrospective chart review was performed to evaluate @entity1 treatments in 376 episodes with 115 Olmsted County @entity0 seen by a clinician at Mayo Clinic in Rochester, Minnesota, between 1968 and 2008. Treatment episode outcomes were recorded from clinical notes for the 73 treatment episodes that had a follow-up period of more than 30 days. RESULTS: Systemic antibiotics alone were prescribed most frequently in 70.0% of episodes. Systemic antibiotics alone improved 39 of 49 treatment episodes (79.6%), including 13 episodes (26.5%) when the disease was fully cleared. All 5 of 5 episodes (100%) of surgical treatment alone improved, including 4 (80%) in which the disease was fully cleared. Surgery in combination with systemic antibiotic treatment yielded improvement in 5 episodes (71.4%), with 2 episodes (28.6%) showing complete clearance. CONCLUSION: Systemic antibiotics were the most frequently prescribed treatment type in 115 @entity0 over a 40-year period. Both systemic antibiotic therapy and surgical treatment are effective in disease management.

title: Treatment experience in a local population with XXXX .

answer: @entity1


abstract: OBJECTIVES: Seasonal trends were demonstrated in reproduction and sexual activity. Through the secretion ofmelatonin the pineal gland plays an important role in the neuroendocrine control of sexual function and reproductive physiology. We hypothesized that inhibition of the pineal gland activity through a light treatment may favorably affect sexual function. METHODS: We recruited 24 subjects with a diagnosis of @entity3 and/or primary @entity3 . The subjects were randomly assigned to either active light treatment (ALT) or placebo light treatment (L-PBO). @entity0 were assessed during the first evaluation and after 2 weeks of treatment, using the Structured Clinical Interview for Sexual Disorders DSM-IV (SCID-S) and a self-administered rating scale of the level of sexual satisfaction (1 to 10). Repeated ANOVA measures were performed to compare the two groups of @entity0 . Post-hoc analysis was performed by Holm-Sidak test for repeated comparisons. Results. At baseline the two groups were comparable. After 2 weeks the group treated with Light Therapy showed a significant improvement in sexual satisfaction, about 3 times higher than the group that received placebo, while no significant improvement was observed in the group L-PBO. Conclusions. Our results confirm a potentially beneficial effect of Light Therapy on primary @entity1 . In the future, we propose to correlate clinical findings with @entity2 levels pre/post treatment.

title: [Light therapy as a treatment for XXXX --beyond a pilot study].

answer: @entity1


abstract: Mutations in the @entity8 gene result in @entity0 , characterized by persistent @entity6 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity7 is reported to lower serum @entity5 by decreasing @entity4 -dependent @entity5 co-transporters in the gut and kidney. However, its effectiveness in @entity0 remains unknown. In this study, we investigated @entity7 as a potential therapy for @entity0 , using a @entity1 model of the disease- @entity8 knockout @entity1 . Initially, five different doses of @entity7 were given to normal heterozygous @entity1 intraperitoneally or orally. Treatment had no effect on serum @entity5 levels, but serum levels of a phosphaturic hormone, @entity9 ( @entity9 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity7 (40mM) was tested in @entity8 knockout @entity1 fed a high @entity5 diet. The radiographic data pre- and post-treatment showed that @entity7 did not reverse the @entity3 . However, the treatment retarded @entity3 growth after 4weeks, while in the untreated animals, @entity3 increased in size. The therapy did not affect serum @entity5 levels, but intact @entity9 decreased in the treated @entity1 . The treated @entity1 also had increased @entity2 in the heart. In summary, @entity7 did not alter serum @entity5 levels, likely due to compensatory decrease in @entity9 to counteract the @entity5 lowering effect of @entity7 . Although increased @entity2 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity3 .

title: @entity7 treatment in a @entity1 model of @entity0 reduces serum XXXX and raises heart @entity2 .

answer: @entity9


abstract: Mutations in the @entity8 gene result in @entity0 , characterized by persistent @entity6 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity7 is reported to lower serum @entity5 by decreasing @entity4 -dependent @entity5 co-transporters in the gut and kidney. However, its effectiveness in @entity0 remains unknown. In this study, we investigated @entity7 as a potential therapy for @entity0 , using a @entity1 model of the disease- @entity8 knockout @entity1 . Initially, five different doses of @entity7 were given to normal heterozygous @entity1 intraperitoneally or orally. Treatment had no effect on serum @entity5 levels, but serum levels of a phosphaturic hormone, @entity9 ( @entity9 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity7 (40mM) was tested in @entity8 knockout @entity1 fed a high @entity5 diet. The radiographic data pre- and post-treatment showed that @entity7 did not reverse the @entity3 . However, the treatment retarded @entity3 growth after 4weeks, while in the untreated animals, @entity3 increased in size. The therapy did not affect serum @entity5 levels, but intact @entity9 decreased in the treated @entity1 . The treated @entity1 also had increased @entity2 in the heart. In summary, @entity7 did not alter serum @entity5 levels, likely due to compensatory decrease in @entity9 to counteract the @entity5 lowering effect of @entity7 . Although increased @entity2 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity3 .

title: XXXX treatment in a @entity1 model of @entity0 reduces serum @entity9 and raises heart @entity2 .

answer: @entity7


abstract: Mutations in the @entity8 gene result in @entity0 , characterized by persistent @entity6 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity7 is reported to lower serum @entity5 by decreasing @entity4 -dependent @entity5 co-transporters in the gut and kidney. However, its effectiveness in @entity0 remains unknown. In this study, we investigated @entity7 as a potential therapy for @entity0 , using a @entity1 model of the disease- @entity8 knockout @entity1 . Initially, five different doses of @entity7 were given to normal heterozygous @entity1 intraperitoneally or orally. Treatment had no effect on serum @entity5 levels, but serum levels of a phosphaturic hormone, @entity9 ( @entity9 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity7 (40mM) was tested in @entity8 knockout @entity1 fed a high @entity5 diet. The radiographic data pre- and post-treatment showed that @entity7 did not reverse the @entity3 . However, the treatment retarded @entity3 growth after 4weeks, while in the untreated animals, @entity3 increased in size. The therapy did not affect serum @entity5 levels, but intact @entity9 decreased in the treated @entity1 . The treated @entity1 also had increased @entity2 in the heart. In summary, @entity7 did not alter serum @entity5 levels, likely due to compensatory decrease in @entity9 to counteract the @entity5 lowering effect of @entity7 . Although increased @entity2 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity3 .

title: @entity7 treatment in a @entity1 model of XXXX reduces serum @entity9 and raises heart @entity2 .

answer: @entity0


abstract: Mutations in the @entity8 gene result in @entity0 , characterized by persistent @entity6 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity7 is reported to lower serum @entity5 by decreasing @entity4 -dependent @entity5 co-transporters in the gut and kidney. However, its effectiveness in @entity0 remains unknown. In this study, we investigated @entity7 as a potential therapy for @entity0 , using a @entity1 model of the disease- @entity8 knockout @entity1 . Initially, five different doses of @entity7 were given to normal heterozygous @entity1 intraperitoneally or orally. Treatment had no effect on serum @entity5 levels, but serum levels of a phosphaturic hormone, @entity9 ( @entity9 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity7 (40mM) was tested in @entity8 knockout @entity1 fed a high @entity5 diet. The radiographic data pre- and post-treatment showed that @entity7 did not reverse the @entity3 . However, the treatment retarded @entity3 growth after 4weeks, while in the untreated animals, @entity3 increased in size. The therapy did not affect serum @entity5 levels, but intact @entity9 decreased in the treated @entity1 . The treated @entity1 also had increased @entity2 in the heart. In summary, @entity7 did not alter serum @entity5 levels, likely due to compensatory decrease in @entity9 to counteract the @entity5 lowering effect of @entity7 . Although increased @entity2 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity3 .

title: @entity7 treatment in a XXXX model of @entity0 reduces serum @entity9 and raises heart @entity2 .

answer: @entity1


abstract: Mutations in the @entity8 gene result in @entity0 , characterized by persistent @entity6 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity7 is reported to lower serum @entity5 by decreasing @entity4 -dependent @entity5 co-transporters in the gut and kidney. However, its effectiveness in @entity0 remains unknown. In this study, we investigated @entity7 as a potential therapy for @entity0 , using a @entity1 model of the disease- @entity8 knockout @entity1 . Initially, five different doses of @entity7 were given to normal heterozygous @entity1 intraperitoneally or orally. Treatment had no effect on serum @entity5 levels, but serum levels of a phosphaturic hormone, @entity9 ( @entity9 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity7 (40mM) was tested in @entity8 knockout @entity1 fed a high @entity5 diet. The radiographic data pre- and post-treatment showed that @entity7 did not reverse the @entity3 . However, the treatment retarded @entity3 growth after 4weeks, while in the untreated animals, @entity3 increased in size. The therapy did not affect serum @entity5 levels, but intact @entity9 decreased in the treated @entity1 . The treated @entity1 also had increased @entity2 in the heart. In summary, @entity7 did not alter serum @entity5 levels, likely due to compensatory decrease in @entity9 to counteract the @entity5 lowering effect of @entity7 . Although increased @entity2 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity3 .

title: @entity7 treatment in a @entity1 model of @entity0 reduces serum @entity9 and raises heart XXXX .

answer: @entity2


abstract: BACKGROUND: @entity2 vein diameters during compression with two different stocking brands are assessed as well as quality of life. @entity0 AND METHODS: 60 subjects (53 female) with @entity1 were randomized to either wearing the Venotrain micro   (VM) or the Venotrain ulcertec   (VU) compression stocking for 2 weeks. All @entity2 - veins were assessed in cross - sectional plane by Duplexsonography native and through the compression stockings. The diameters of 2 gastrocnemius muscle - veins (GV), the short saphenous vein ( @entity4 ) and the posterior tibial vein ( @entity3 ) were compared intra - individually, with and without compression. RESULTS: Mean diameters (   SD) decreased significantly under compression (p < 0.0001) in the standing position: in the antero-posterior (ap) plane of the GV by 6.5 (   16.6) % under VU and 8.2 (   16.5) % under VM, in the @entity4 9.7 (   15.8) % under VU and 5.7 (   19.2) % under VM. No significant change (p = 0.48) was seen in the @entity3 . In the prone position the relative ap - diameter changes in the medial GV were significantly smaller for the VM (37.5    51.0 %) compared to the VU compression stocking (52.4    51.8 %) (p = 0.016). The quality of life assessment scores improved significantly for the VU - and the VM - compression stocking. Venous diameters did not correlate with quality of life scores. CONCLUSIONS: Intra - individually tested the @entity2 muscle vein diameters decrease under compression, more pronounced in the prone than in the standing position. In the ankle area the @entity3 does not decrease in standing subjects. Quality of life assessed increases for both compression stockings.

title: Impact of compression stockings on XXXX -vein diameters and on quality of life parameters in subjects with @entity1 .

answer: @entity2


abstract: BACKGROUND: @entity2 vein diameters during compression with two different stocking brands are assessed as well as quality of life. @entity0 AND METHODS: 60 subjects (53 female) with @entity1 were randomized to either wearing the Venotrain micro   (VM) or the Venotrain ulcertec   (VU) compression stocking for 2 weeks. All @entity2 - veins were assessed in cross - sectional plane by Duplexsonography native and through the compression stockings. The diameters of 2 gastrocnemius muscle - veins (GV), the short saphenous vein ( @entity4 ) and the posterior tibial vein ( @entity3 ) were compared intra - individually, with and without compression. RESULTS: Mean diameters (   SD) decreased significantly under compression (p < 0.0001) in the standing position: in the antero-posterior (ap) plane of the GV by 6.5 (   16.6) % under VU and 8.2 (   16.5) % under VM, in the @entity4 9.7 (   15.8) % under VU and 5.7 (   19.2) % under VM. No significant change (p = 0.48) was seen in the @entity3 . In the prone position the relative ap - diameter changes in the medial GV were significantly smaller for the VM (37.5    51.0 %) compared to the VU compression stocking (52.4    51.8 %) (p = 0.016). The quality of life assessment scores improved significantly for the VU - and the VM - compression stocking. Venous diameters did not correlate with quality of life scores. CONCLUSIONS: Intra - individually tested the @entity2 muscle vein diameters decrease under compression, more pronounced in the prone than in the standing position. In the ankle area the @entity3 does not decrease in standing subjects. Quality of life assessed increases for both compression stockings.

title: Impact of compression stockings on @entity2 -vein diameters and on quality of life parameters in subjects with XXXX .

answer: @entity1


abstract: The Grynfeltt-Lesshaft @entity2 is a rare posterior abdominal wall defect that allows for the herniation of retro- and intraperitoneal structures through the upper lumbar triangle. While this @entity2 may initially present as a small asymptomatic bulge, the defect typically enlarges over time and can become symptomatic with potentially serious complications. In order to avoid that outcome, it is advisable to electively repair Grynfeltt hernias in @entity0 without significant contraindications to surgery. Due to the limited number of lumbar hernioplasties performed, there has not been a large study that definitively identifies the best repair technique. It is generally accepted that @entity3 such as these should be repaired by tension-free methods. Both laparoscopic and open techniques are described in modern literature with unique advantages and complications for each. We present the case of an unexpected Grynfeltt @entity2 diagnosed following an attempted @entity1 resection. We chose to perform an open repair involving a combination of fascial approximation and dual-layer @entity4 mesh placement. The @entity0 's recovery was uneventful and there has been no evidence of recurrence at over six months. Our goal herein is to increase awareness of @entity2 and to discuss approaches to their surgical management.

title: Grynfeltt Hernia: A Deceptive Lumbar Mass with a XXXX -Like Presentation.

answer: @entity1


abstract: Endogenous @entity8 ( @entity8 ) is a lipid-soluble antioxidant and essential for the electron transport chain. We previously demonstrated that @entity2 enhanced @entity8 levels, whereas disruption of mitochondrial membrane potential by a chemical uncoupler suppressed @entity8 levels, in @entity0 143B cells. In this study, we investigated how @entity8 levels and expression of two PDSS and eight COQ genes were affected by @entity6 , which inhibited @entity3 synthesis at Complex V without uncoupling the mitochondria. We confirmed that @entity6 increased the production of reactive @entity1 species (ROS) and decreased mitochondria-dependent @entity3 production in 143B cells. We also demonstrated that @entity8 levels were decreased by @entity6 after 42 or 48 h of treatment, but not at earlier time points. Expression of @entity9 and @entity10 - @entity11 were up-regulated after 18-hour @entity6 treatment, and the expression of @entity7 (PGC1-1a) elevated concurrently. Knockdown of @entity7 down-regulated the basal mRNA levels of @entity9 and five COQ genes and suppressed the induction of @entity13 and @entity11 genes by @entity6 , but did not affect @entity8 levels under these conditions. @entity4 suppressed the augmentation of ROS levels and the enhanced expression of @entity10 , @entity14 , @entity12 , and @entity11 induced by @entity6 , but did not modulate the changes in @entity8 levels. These results suggested that the condition of @entity5 induced by @entity6 decreased @entity8 levels independent of oxidative stress. Up-regulation of @entity9 and several COQ genes by @entity6 might be regulated by multiple mechanisms, including the signaling pathways mediated by @entity7 and ROS, but it would not restore @entity8 levels.

title: Suppression of coenzyme Q       levels and the induction of multiple PDSS and COQ genes in @entity0 cells following XXXX treatment.

answer: @entity6


abstract: Endogenous @entity8 ( @entity8 ) is a lipid-soluble antioxidant and essential for the electron transport chain. We previously demonstrated that @entity2 enhanced @entity8 levels, whereas disruption of mitochondrial membrane potential by a chemical uncoupler suppressed @entity8 levels, in @entity0 143B cells. In this study, we investigated how @entity8 levels and expression of two PDSS and eight COQ genes were affected by @entity6 , which inhibited @entity3 synthesis at Complex V without uncoupling the mitochondria. We confirmed that @entity6 increased the production of reactive @entity1 species (ROS) and decreased mitochondria-dependent @entity3 production in 143B cells. We also demonstrated that @entity8 levels were decreased by @entity6 after 42 or 48 h of treatment, but not at earlier time points. Expression of @entity9 and @entity10 - @entity11 were up-regulated after 18-hour @entity6 treatment, and the expression of @entity7 (PGC1-1a) elevated concurrently. Knockdown of @entity7 down-regulated the basal mRNA levels of @entity9 and five COQ genes and suppressed the induction of @entity13 and @entity11 genes by @entity6 , but did not affect @entity8 levels under these conditions. @entity4 suppressed the augmentation of ROS levels and the enhanced expression of @entity10 , @entity14 , @entity12 , and @entity11 induced by @entity6 , but did not modulate the changes in @entity8 levels. These results suggested that the condition of @entity5 induced by @entity6 decreased @entity8 levels independent of oxidative stress. Up-regulation of @entity9 and several COQ genes by @entity6 might be regulated by multiple mechanisms, including the signaling pathways mediated by @entity7 and ROS, but it would not restore @entity8 levels.

title: Suppression of coenzyme Q       levels and the induction of multiple PDSS and COQ genes in XXXX cells following @entity6 treatment.

answer: @entity0


abstract: Objective To determine the economic feasibility in Australian general practices of using a practice nurse (PN)-led care model of @entity3 management. Methods A cost-analysis of item numbers from the @entity5 ( @entity5 ) was performed in three Australian general practices, one urban, one regional and one rural. @entity0 (n =254; >18 years of age) with chronic conditions (type 2 @entity1 , @entity2 , @entity4 ) but without unstable or major health problems were randomised into usual general practitioner (GP) or PN-led care for management of their condition over a period of 12 months. After the 12-month intervention, total @entity5 item charges were evaluated for @entity0 managed for their stable chronic condition by usual GP or PN-led care. Zero-skewness log transformation was applied to cost data and log-linear regression analysis was undertaken. Results There was an estimated A 129 mean increase in total @entity5 item charges over a 1-year period (controlled for age, self-reported quality of life and geographic location of practice) associated with PN-led care. The frequency of GP and PN visits varied markedly according to the @entity3 . Conclusions Medicare reimbursements provided sufficient funding for general practices to employ PNs within limits of workloads before the new Practice Nurse Incentive Program was introduced in July 2012. What is known about the topic? The integration of practice nurses (PN) into the Australian health system is limited compared with the UK and other parts of Europe. There are known @entity0 benefits of PNs collaborating with general practitioners, especially in @entity3 management, but the benefits from a financial perspective are less clear. What does this paper add? The cost-analysis of a PN-led model of @entity3 management in Australian general practice is reported, providing an indication of the financial impact of using PNs in primary healthcare. What are the implications for practitioners? Taking into account general practice and individual PN workloads, sufficient funding for employment of PNs is provided by Medicare reimbursements.

title: Revenue effects of practice nurse-led care for XXXX .

answer: @entity3


abstract: Xp11.2 @entity5 ( @entity5 ) is rare and predominantly found in @entity0 and young adults. Because of the property of overexpressed @entity7 ( @entity7 ) fusion protein, immunohistochemical (IHC) staining with @entity7 antibody makes an excellent diagnostic tool. This study analyzed preliminary experiences of eight Xp11.2 translocation RCCs in our institution between 2007 and 2012. In four males and four females with a mean age of 28.4 years. Xp11.2 translocation RCCs were diagnosed. @entity7 IHC stain was positive in all @entity2 specimens. As the initial presentation, four @entity0 suffered from @entity3 , three cases had gross @entity4 , and one case had @entity6 caused by existing lung @entity1 . The @entity2 was located in the right kidney (75%) with mean diameter of 5.85    2.64 cm. Three cases (38%, 3/8) presented with lymph node @entity1 at the time of diagnosis. In five cases (63%, 5/8), the initial diagnosis was Stage III and IV. Treatment included open surgery (one partial nephrectomy and five radical nephrectomies), cryoablation, immunotherapy, and target therapy. The mean follow-up time was 32 months. One @entity0 died after 23.4 months of follow-up. The application of @entity7 IHC stain will improve the diagnostic accuracy for detecting XP11.2 @entity5 . Surgery or cryoablation both had excellent prognosis in early stages. Although the disease is believed to be indolent, an increasingly aggressive clinical course should be kept in mind, especially for @entity0 and young adults.

title: The preliminary experiences of XXXX and literature review.

answer: @entity5


abstract: BACKGROUND: Olfactory loss is highly prevalent, and comorbid @entity4 are common. Considering olfactory input is highly interconnected with the limbic system, and that the limbic system manages mood, it is predictable that impairments in the sense of smell may result in mood changes. METHODOLOGY: Chronic olfactory deficits were induced by repeated intranasal irrigation of @entity5 for 12 weeks in BALB/c @entity0 . H_E staining, OMP staining, and @entity3 chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate @entity2 , as well as open field, elevated plus maze tests were applied to assess @entity1 . The mRNA levels of glucocorticoid receptor (GR) and corticotropin releasing hormone ( @entity6 ) were measured by real-time PCR to confirm relevant molecular changes. RESULTS: Disruption of the olfactory epithelium and olfactory loss was confirmed in histological studies and @entity3 chip finding test. Behavioral tests show that the chronic anosmic state caused increased @entity2 and reduced @entity1 . PCR data showed that mRNA levels of GR in the hypothalamus and @entity6 in the amygdala were significantly decreased. CONCLUSIONS: These results propose that @entity5 -induced chronic anosmia can cause a @entity2 and anxiolytic state via decreased hypothalamic GR and amygdalar @entity6 .

title: Chronic anosmia induces depressive behavior and reduced XXXX via dysregulation of glucocorticoid receptor and @entity6 in a @entity0 model.

answer: @entity1


abstract: BACKGROUND: Olfactory loss is highly prevalent, and comorbid @entity4 are common. Considering olfactory input is highly interconnected with the limbic system, and that the limbic system manages mood, it is predictable that impairments in the sense of smell may result in mood changes. METHODOLOGY: Chronic olfactory deficits were induced by repeated intranasal irrigation of @entity5 for 12 weeks in BALB/c @entity0 . H_E staining, OMP staining, and @entity3 chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate @entity2 , as well as open field, elevated plus maze tests were applied to assess @entity1 . The mRNA levels of glucocorticoid receptor (GR) and corticotropin releasing hormone ( @entity6 ) were measured by real-time PCR to confirm relevant molecular changes. RESULTS: Disruption of the olfactory epithelium and olfactory loss was confirmed in histological studies and @entity3 chip finding test. Behavioral tests show that the chronic anosmic state caused increased @entity2 and reduced @entity1 . PCR data showed that mRNA levels of GR in the hypothalamus and @entity6 in the amygdala were significantly decreased. CONCLUSIONS: These results propose that @entity5 -induced chronic anosmia can cause a @entity2 and anxiolytic state via decreased hypothalamic GR and amygdalar @entity6 .

title: Chronic anosmia induces depressive behavior and reduced @entity1 via dysregulation of glucocorticoid receptor and XXXX in a @entity0 model.

answer: @entity6


abstract: BACKGROUND: Olfactory loss is highly prevalent, and comorbid @entity4 are common. Considering olfactory input is highly interconnected with the limbic system, and that the limbic system manages mood, it is predictable that impairments in the sense of smell may result in mood changes. METHODOLOGY: Chronic olfactory deficits were induced by repeated intranasal irrigation of @entity5 for 12 weeks in BALB/c @entity0 . H_E staining, OMP staining, and @entity3 chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate @entity2 , as well as open field, elevated plus maze tests were applied to assess @entity1 . The mRNA levels of glucocorticoid receptor (GR) and corticotropin releasing hormone ( @entity6 ) were measured by real-time PCR to confirm relevant molecular changes. RESULTS: Disruption of the olfactory epithelium and olfactory loss was confirmed in histological studies and @entity3 chip finding test. Behavioral tests show that the chronic anosmic state caused increased @entity2 and reduced @entity1 . PCR data showed that mRNA levels of GR in the hypothalamus and @entity6 in the amygdala were significantly decreased. CONCLUSIONS: These results propose that @entity5 -induced chronic anosmia can cause a @entity2 and anxiolytic state via decreased hypothalamic GR and amygdalar @entity6 .

title: Chronic anosmia induces depressive behavior and reduced @entity1 via dysregulation of glucocorticoid receptor and @entity6 in a XXXX model.

answer: @entity0


abstract: The purpose of this study was to determine if bone metastasis characteristics on axial skeleton MRI are associated with either skeletal-related events (SREs) or survival in @entity0 @entity1 . A retrospective review was performed on 247 @entity0 @entity1 with bone metastases identified on axial skeleton MRI. MRI studies were reviewed for metastases T1 signal, signal uniformity, complete vertebral metastatic marrow replacement, metastases quantity, and distribution. Odds ratio (OR) and hazard ratios (HR) were calculated, with 95  % confidence intervals (95  % CI), to determine association with either future SREs or survival. At the time of analysis, 174 (70  %) @entity1 had developed SREs and 176 (71  %) @entity1 were dead. Features of skeletal metastases associated with SREs included the presence of complete metastatic marrow replacement within any vertebra; OR 2.363 (95  % CI 1.240-4.504, P  =  0.0090), and more widely distributed metastases; OR 1.239 (95  % CI 1.070-1.435, P  =  0.0040). Features associated with shorter survival included the presence of complete metastatic marrow replacement within any vertebra; HR 1.500 (95  % CI 1.105-2.036, P  =  0.0093), and more widely distributed metastases; HR 1.141 (95  % CI 1.047-1.243, P  =  0.0027). Metastases T1 signal, signal uniformity, and surprisingly quantity were not associated with SREs or survival. Axial skeleton MRI was able to identify characteristics predictive of future SREs and survival. These characteristics could be used for risk stratification for future trials if prospectively validated.

title: XXXX and bone metastases: the association of axial skeleton MRI findings with skeletal-related events and survival.

answer: @entity0


abstract: BACKGROUND: The association between maternal @entity1 and adverse outcomes in @entity0 is well established. Similar links have been found for maternal @entity2 . One proposed pathway of risk transmission is reduced maternal emotional availability. Our aim was to investigate whether sensitive parenting is impaired in mothers with @entity1 in remission, and whether among these mothers @entity2 has an additional impact. METHODS: The mother- @entity0 interaction of 188 dyads was assessed during a play situation using the Emotional Availability Scales, which measure the overall affective quality of the interaction: maternal sensitivity, structuring, nonhostility, and nonintrusiveness. Mothers with @entity1 in remission were compared to healthy mothers. @entity0 were between 5 and 12 years old. Group differences and impact of additional @entity2 were analyzed by one-factorial analyses of covariance and planned contrasts. RESULTS: Mothers with @entity1 in remission showed less emotional availability during mother- @entity0 interaction compared to healthy control mothers. Specifically, they were less sensitive and, at trend-level, less structuring and more hostile. Among these mothers, we found an additional effect of severe maternal @entity2 on maternal sensitivity: Mothers with @entity1 in remission and a history of severe @entity2 were less sensitive than remitted mothers without @entity2 . CONCLUSIONS: Our data suggest that @entity1 impacts on maternal emotional availability during remission, which might represent a trait characteristic of @entity1 . Mothers with @entity1 in remission and additional severe @entity2 were particularly affected. These findings may contribute to the understanding of @entity0 's vulnerability to develop a @entity1 themselves.

title: EMOTIONAL AVAILABILITY IN MOTHER- XXXX INTERACTION: THE EFFECTS OF MATERNAL DEPRESSION IN REMISSION AND ADDITIONAL HISTORY OF CHILDHOOD ABUSE.

answer: @entity0


abstract: OBJECTIVES: To detect metastatic @entity0 of less than 1 mm in size by focusing on the clearance of contrast material using synchrotron radiation (SR) angiography characterized by high spatial resolution and high-sensitivity receiver. METHODS: C6 cells, derived from @entity3 @entity2 cells, were injected to the @entity3 tail vein. Two weeks after injection, the @entity3 underwent SR angiography using a high-gain avalanche rushing amorphous photoconductor (HARP) receiver of extra-high sensitivity with high contrast resolution. The 256-grayscale value was employed in the analysis of images. RESULTS: 19 nodules were identified in images. The @entity1 were confirmed histopathologically. The average @entity1 size was 621  193   m. The clearance curve of the densities was expressed as a logarithm function. @entity1 showed delayed clearance of contrast material, taking up to 28 s, compared with arteries, which cleared rapidly at 8 s. In 256 grayscale, the distance was 50. This gap in density clearance made it possible to identify @entity1 . CONCLUSIONS: SR angiography with a HARP receiver provides high sensitivity and spatial resolution and makes it possible to diagnose metastatic @entity0 of less than 1 mm in size by focusing on differences in the clearance times of contrast material.

title: Focusing on delayed clearance for identifying small-sized metastatic XXXX using synchrotron radiation angiography with a highly sensitive receiver.

answer: @entity0


abstract: PURPOSE: The detection of circulating @entity1 cells (CTCs) provides important prognostic information in @entity0 with @entity2 . We aim to determine the rate of detection of CTCs in @entity0 with high-risk non- @entity2 using the CellSearch(  ) method. METHOD: Samples of peripheral blood (7.5  mL) were drawn from 36 @entity0 with newly diagnosed high-risk non- @entity2 , prior to any initiation of therapy and analyzed for CTCs using the CellSearch(  ) method. RESULTS: The median age was 70  years, median PSA was 14.1, and the median Gleason score was 9. The median 5-year risk of progression of disease using a validated nomogram was 39  %. Five out of 36 @entity0 (14  %, 95  % CI 5-30  %) had CTCs detected in their circulation. Four @entity0 had only 1 CTC per 7.5  mL of blood detected. One @entity0 had 3 CTCs per 7.5  mL of blood detected, which included a circulating @entity1 microemboli. Both on univariate analysis and multivariate analysis, there were no correlations found between CTC positivity and the classic prognostic factors including PSA, Gleason score, T-stage and age. CONCLUSION: This study demonstrates that @entity0 with high-risk, non- @entity2 present infrequently with small number of CTCs in peripheral blood. This finding is consistent with the limited literature available in this setting. Other CTC isolation and detection technologies with improved sensitivity and specificity may enable detection of CTCs with mesenchymal phenotypes, although none as yet have been validated for clinical use. Newer assays are emerging for detection of new putative biomarkers for @entity2 . Correlation of disease control outcomes with CTC detection will be important.

title: Circulating @entity1 cell detection in high-risk non- XXXX .

answer: @entity2


abstract: PURPOSE: The detection of circulating @entity1 cells (CTCs) provides important prognostic information in @entity0 with @entity2 . We aim to determine the rate of detection of CTCs in @entity0 with high-risk non- @entity2 using the CellSearch(  ) method. METHOD: Samples of peripheral blood (7.5  mL) were drawn from 36 @entity0 with newly diagnosed high-risk non- @entity2 , prior to any initiation of therapy and analyzed for CTCs using the CellSearch(  ) method. RESULTS: The median age was 70  years, median PSA was 14.1, and the median Gleason score was 9. The median 5-year risk of progression of disease using a validated nomogram was 39  %. Five out of 36 @entity0 (14  %, 95  % CI 5-30  %) had CTCs detected in their circulation. Four @entity0 had only 1 CTC per 7.5  mL of blood detected. One @entity0 had 3 CTCs per 7.5  mL of blood detected, which included a circulating @entity1 microemboli. Both on univariate analysis and multivariate analysis, there were no correlations found between CTC positivity and the classic prognostic factors including PSA, Gleason score, T-stage and age. CONCLUSION: This study demonstrates that @entity0 with high-risk, non- @entity2 present infrequently with small number of CTCs in peripheral blood. This finding is consistent with the limited literature available in this setting. Other CTC isolation and detection technologies with improved sensitivity and specificity may enable detection of CTCs with mesenchymal phenotypes, although none as yet have been validated for clinical use. Newer assays are emerging for detection of new putative biomarkers for @entity2 . Correlation of disease control outcomes with CTC detection will be important.

title: Circulating XXXX cell detection in high-risk non- @entity2 .

answer: @entity1


abstract: The aim of the present study was to find out whether early cardiac changes in @entity0 receiving chemotherapy can be detected by the conventional and deformation parameters of 2D and 3D echocardiography. Twenty-five healthy subjects with normal regional left ventricular function (group 1) and 25 @entity0 receiving chemotherapy (group 2) underwent 2D and 3D transthoracic echocardiography (Toshiba Artida Medical System). All @entity0 (group 2) were examined before and during @entity2 chemotherapy at a 3-month follow-up. Left ventricular volumes, ejection fraction, muscle mass, global longitudinal, global radial, global circumferential strain, and rotation were analyzed with 2D and 3D echocardiography, while twist and time-to-peak-intervals were analyzed with 3D echocardiography. For left ventricular volumes and muscle mass, no significant differences were seen between the two study groups (P<0.05). According to our results, @entity1 induced by @entity2 chemotherapy can be detected by 2D global radial strain. Detecting @entity1 by global longitudinal and circumferential strain requires more than 3 months follow-up. Changes in rotation, twist or time-to-peak intervals could not be verified at the 3-month follow-up in the present study. 2D global radial strain seems to be the most sensitive and robust parameter to detect early @entity1 during chemotherapy. 3D echocardiography is not yet an established method to detect @entity1 in clinical practice due to lower spatial and temporal resolution.

title: Early detection of XXXX by 2D and 3D deformation imaging in @entity0 receiving chemotherapy.

answer: @entity2


abstract: The aim of the present study was to find out whether early cardiac changes in @entity0 receiving chemotherapy can be detected by the conventional and deformation parameters of 2D and 3D echocardiography. Twenty-five healthy subjects with normal regional left ventricular function (group 1) and 25 @entity0 receiving chemotherapy (group 2) underwent 2D and 3D transthoracic echocardiography (Toshiba Artida Medical System). All @entity0 (group 2) were examined before and during @entity2 chemotherapy at a 3-month follow-up. Left ventricular volumes, ejection fraction, muscle mass, global longitudinal, global radial, global circumferential strain, and rotation were analyzed with 2D and 3D echocardiography, while twist and time-to-peak-intervals were analyzed with 3D echocardiography. For left ventricular volumes and muscle mass, no significant differences were seen between the two study groups (P<0.05). According to our results, @entity1 induced by @entity2 chemotherapy can be detected by 2D global radial strain. Detecting @entity1 by global longitudinal and circumferential strain requires more than 3 months follow-up. Changes in rotation, twist or time-to-peak intervals could not be verified at the 3-month follow-up in the present study. 2D global radial strain seems to be the most sensitive and robust parameter to detect early @entity1 during chemotherapy. 3D echocardiography is not yet an established method to detect @entity1 in clinical practice due to lower spatial and temporal resolution.

title: Early detection of @entity2 by 2D and 3D deformation imaging in XXXX receiving chemotherapy.

answer: @entity0


abstract: When @entity4 are viewed from an evolutionary biology perspective, a heightened thrifty and an inflammatory design could be their mechanisms. @entity0 ancestors confronted a greater infectious load and were subjected to the selection for proinflammatory genes and a strong inflammatory function. Ancestors also faced starvation periods that pressed for a thrifty genotype which caused fat accumulation. The pressure of sustaining gluconeogenesis during periods of poor nourishment selected individuals with insulin resistance. Obesity induces a proinflammatory state due to the secretion of adipokines which underlie @entity5 . Our actual lifestyle needs no more of such proinflammatory and thrifty genotypes and these ancestral genes might increase predisposition to diseases. Risk factors for @entity6 and @entity1 are based on inflammatory and genetic foundations that can be accounted for by excess fat. Longevity has also increased in recent times and is related to a proinflammatory response with cardiovascular consequences. If @entity0 ancestral lifestyle could be recovered by increasing exercise and adapting a calorie restriction diet, @entity2 would decrease and the effects on chronic low-grade @entity3 would be limited. Thereby, the rates of both @entity6 and @entity1 could be reduced.

title: An Evolutionary Perspective of Nutrition and Inflammation as Mechanisms of XXXX .

answer: @entity4


abstract: BACKGROUND: Assessment of bone quality can guide spinal surgery. However, surgeons infrequently evaluate bone quality in a quantitative manner. Recent literature suggests a role for computed tomography (CT) Hounsfield units (HUs) as a marker for bone quality. Limited data exist regarding its utility with respect to posterolateral lumbar fusion (PLF). METHODS: From fall 2010 to winter 2012, 10 @entity0 underwent revision surgery for symptomatic @entity2 (defined as intractable @entity1 associated with either radiographic evidence of nonunion or intraoperative evidence of nonunion) after a prior L4-S1 PLF. These @entity0 were age-matched (  5 years) to 10 @entity0 who underwent L4-S1 PLF with no clinical signs of @entity2 at 1-year follow-up. Available CT imaging (with or without instrumentation) was evaluated from L1 to L5 for the averaged HU. Data were pooled among L1-L3 values and between L4 and L5 values. RESULTS: Within the @entity2 group, the pooled L1-L3 HU value was similar to the pooled L4-L5 HU value (168.39    22.84 HU vs. 166.98    23.20 HU respectively, P = 0.89). The same pattern was observed for the control group (190.24    37.13 HU vs. 201.89    36.59 HU respectively, P = 0.44). On the other hand, the pooled L1-L3 and L4-L5 HU values were larger for the control group compared to the @entity2 group, with the pooled L4-L5 HU demonstrating statistical significance, P = 0.01. CONCLUSION: Currently, CT imaging is typically not obtained prior to lumbar fusion. Results demonstrated that CT HU values were significantly larger for @entity0 who did not exhibit symptomatic @entity2 at 1-year follow-up compared to those who required revision surgery. As such, CT HU values may serve as a predictor for bony fusion to guide surgical management of @entity0 under consideration for PLF.

title: Posterolateral lumbar fusion: Relationship between computed tomography Hounsfield units and symptomatic XXXX .

answer: @entity2


abstract: BACKGROUND: Aim of the present study was to evaluate prognostic factors, in particular standard laboratory parameters, for better outcome after @entity2 (SSNHL). METHODS: Using a retrospective review, 173 @entity0 were included presenting between 2006 and 2009 with unilateral SSNHL, >= 30  dB bone conduction in three succeeding frequencies between 0.125 to 8  kHz in pure tone audiometry (PTA), and a time interval between first symptoms and diagnostics    <=   4  weeks. Hearing gain of <10  dB versus >= 10  dB in the affected ear in 6PTA values was the primary outcome criterion. Univariate and multivariate statistical tests were used to analyze predictors for better outcome. RESULTS: The initial @entity1 was 50.6        27.2  dB. The absolute @entity1 was 15.6        20.1  dB. Eighty-one @entity0 (47%) had a final @entity1 of >= 10  dB. @entity3 (p <0.0001); start of inpatient treatment <4  days after onset (p   =   0.018); first SSNHL (versus recurrent SSNHL, p   =   0.001); initial @entity1   >=    60  dB (p   <   0.0001); an initial quick value lower than the reference values (p   =   0.040); and a pretherapeutic hyperfibrinogenemia (p   =   0.007) were significantly correlated to better outcome (>= 10  dB absolute @entity1 ). Multivariate analysis revealed that first SSNHL (p   =   0.004), start of treatment <4  days after onset (p   =   0.015), initial @entity1   >=    60  dB (p   =   0.001), and hyperfibrinogenemia (p   =   0.032) were independent prognostic factors for better hearing recovery. CONCLUSION: Better @entity1 in @entity0 with hyperfibrinogenemia might be explained by the rheological properties of the applied therapy and supports the hypothesis that SSNHL is caused in part by vascular factors.

title: Prognostic impact of standard laboratory values on outcome in @entity0 with sudden XXXX .

answer: @entity2


abstract: BACKGROUND: Aim of the present study was to evaluate prognostic factors, in particular standard laboratory parameters, for better outcome after @entity2 (SSNHL). METHODS: Using a retrospective review, 173 @entity0 were included presenting between 2006 and 2009 with unilateral SSNHL, >= 30  dB bone conduction in three succeeding frequencies between 0.125 to 8  kHz in pure tone audiometry (PTA), and a time interval between first symptoms and diagnostics    <=   4  weeks. Hearing gain of <10  dB versus >= 10  dB in the affected ear in 6PTA values was the primary outcome criterion. Univariate and multivariate statistical tests were used to analyze predictors for better outcome. RESULTS: The initial @entity1 was 50.6        27.2  dB. The absolute @entity1 was 15.6        20.1  dB. Eighty-one @entity0 (47%) had a final @entity1 of >= 10  dB. @entity3 (p <0.0001); start of inpatient treatment <4  days after onset (p   =   0.018); first SSNHL (versus recurrent SSNHL, p   =   0.001); initial @entity1   >=    60  dB (p   <   0.0001); an initial quick value lower than the reference values (p   =   0.040); and a pretherapeutic hyperfibrinogenemia (p   =   0.007) were significantly correlated to better outcome (>= 10  dB absolute @entity1 ). Multivariate analysis revealed that first SSNHL (p   =   0.004), start of treatment <4  days after onset (p   =   0.015), initial @entity1   >=    60  dB (p   =   0.001), and hyperfibrinogenemia (p   =   0.032) were independent prognostic factors for better hearing recovery. CONCLUSION: Better @entity1 in @entity0 with hyperfibrinogenemia might be explained by the rheological properties of the applied therapy and supports the hypothesis that SSNHL is caused in part by vascular factors.

title: Prognostic impact of standard laboratory values on outcome in XXXX with sudden @entity2 .

answer: @entity0


abstract: OBJECTIVE: To evaluate the early clinical results of keratoconic eyes treated with transepithelial iontophoresis corneal collagen cross-linking (i-CXL) within 1 year. METHODS: Propective nonrandomized study. Twenty-three eyes of 23 @entity0 with progressive @entity5 with minimum corneal thickness from 380   m to 420   m (including the epithelium) were included in this prospective, nonrandomized clinical study and treated with i-CXL. Scoring of @entity1 , slit lamp examination, uncorrected visual acuity (UCVA) and best corrected distance visual acuity (BCVA), corneal topography, anterior segment optical coherence tomography (AS-OCT), in vivo corneal confocal microscopy and endothelial cell count were assessed before surgery and at 1, 3, 6 and 12 months (m) postoperatively. Paired t test was applied for statistical analysis. RESULTS: Moderate @entity1 were reported by most @entity0 on postoperative Day (D) 1, but rapidly decreased and eventually disappeared on D3. Mild epithelial damage was observed on D1, and the epithelium fully recovered on D3. Improvement of UCVA and BCVA were recorded at 3 months and 12 months postoperatively. Orbscan II corneal topography revealed the significant reductions of Kmax and @entity6 from 3m to 12m (Kmax, t = 2.912, P < 0.01, @entity6 , t = 2.508, P < 0.05) postoperatively while the other parameters remained stable. The Kmax and @entity6 at 12m was (52.94    4.87) and (46.78    3.71) respectively, while the preoperative values was (54.37    5.56) and (48.53    3.57) respectively. Within 1m postoperatively, AS-OCT exhibited an increase of reflectance with a white line (demarcation line) in the anterior stroma, in vivo confocal microscopy also showed the significant thickening and increased connections of collagen fibers with maximal depth of about 133   m. The corneal endothelial cell density remained stable (t = 0.915, P > 0.05). None of the @entity0 showed @entity2 such as @entity3 , scarring, @entity4 , persistent epithelial defect, etc. CONCLUSIONS: Priliminary clinical results within 1 year postoperatively demonstrated the efficacy and safety of i-CXL for the management of progressive @entity5 . This technique was applicable for keratoconic eyes with minimum corneal thickness around 400   m. i-CXL showed the advantage of short time consuming in surgery, rapid recovery and few complication, and has the potential to become a valid alternative for the treatment of @entity5 .

title: [Transepithelial iontophoresis corneal collagen cross-linking for progressive XXXX : one year results].

answer: @entity5


abstract: BACKGROUND AND OBJECTIVES: The objective was to compare the dietary intakes of individuals with @entity2 ( @entity2 ) to individuals without @entity1 in China. METHODS AND STUDY DESIGN: Data are from 1) the 3C Nutrition Ancillary Study, a cross-sectional study of individuals with @entity2 in China, and 2) the China Health and Nutrition Survey. Dietary intake in both samples was assessed using three 24-hour recalls. ANCOVA and multivariable logistic regression, adjusted for sex, age, and urban-rural residence, were used to assess differences in nutrient and food group intake between @entity0 without @entity1 (n=1059) and @entity0 with @entity2 (n=97), who were stratified by insulin regimen (basal-bolus, n=49, versus fixed, n=48). RESULTS: @entity0 with @entity2 had a lower percentage of energy from @entity4 , higher vegetable intake, and were more likely to consume lowfat cakes and fungi/sea weed compared to @entity0 without @entity1 (all p<0.05). Distinguishing characteristics of insulin regimen groups also emerged. @entity0 on fixed regimens had higher intakes of @entity5 and were less likely to consume fruit and more likely to consume high-fat cakes and dairy compared to @entity0 without @entity1 (all p<0.05). @entity0 on basal-bolus regimens were less likely to consume fried foods and more likely to consume fish/shellfish compared to @entity0 without @entity1 (all p<0.05). CONCLUSIONS: Differences in dietary intake between @entity0 with and without @entity2 in China suggest that dietary modifications are common and reflect @entity3 -conscious nutrition recommendations for individuals with @entity2 . Future research should focus on the health effects of these modifications.

title: Comparison of the dietary intakes of individuals with and without XXXX in China.

answer: @entity2


abstract: BACKGROUND: The present study summarizes the 11-year laparoscopic @entity2 surgery experience of a single institution in South Korea and evaluates the current trends of laparoscopic @entity2 surgery through our experience. METHODS: A total of 3000 minimally invasive @entity2 surgeries were performed at Seoul National University Bundang Hospital between May 2003 and January 2014. The types of laparoscopic gastrectomy used, surgical techniques, postoperative morbidities, and long-term oncologic outcomes were analyzed. RESULTS: The proportion of challenging procedures such as laparoscopic total gastrectomy and laparoscopic gastrectomy for @entity0 with advanced @entity2 increased during the study period. The frequency of laparoscopic function-preserving gastrectomy for @entity0 with early-stage @entity1 also increased. The overall rate of complications was 16.7  %; surgical and systemic complication rates were 11.8 and 6.2  %, respectively. There was one case of postoperative mortality due to delayed @entity3 after discharge. Male gender, high BMI, long operating times, combined resection of other organs, and total and proximal gastrectomies were independent predictors of surgical morbidities; however, pathologic T-stage was not a predictable factor. Accumulated experience in laparoscopic surgery decreased the surgical complication rates of total and proximal gastrectomies more than it did in distal gastrectomy over time. The 5-year overall survival rates of @entity0 in advanced stages and those who underwent laparoscopic total gastrectomy were comparable to those reported previously. CONCLUSIONS: Our results indicate the trends toward the expansion of laparoscopic approaches to technically demanding procedures and an increased use of laparoscopic function-preserving surgeries for @entity0 with EGC with acceptable outcomes.

title: Eleven-year experience with 3000 cases of laparoscopic XXXX surgery in a single institution: analysis of postoperative morbidities and long-term oncologic outcomes.

answer: @entity2


abstract: BACKGROUND: @entity9 and @entity10 , cell surface receptors of @entity3 , regulate cell migration and alteration of their expression has been associated with poor prognosis of @entity1 . The aim of this study was to detect their expression in @entity2 to identify associations with another cell adhesion molecule, @entity6 ( @entity6 ), and with clinicopathological data ex vivo, and then explore their potential role in @entity2 cells in vitro. MATERIALS AND METHODS: A total of 172 cases of @entity2 tissue specimens were collected for immunohistochemical analysis of @entity9 , @entity10 , and @entity6 expression. Expression of @entity9 and @entity10 proteins was knocked in or down using their cDNA and shRNA, respectively, in @entity2 cell lines to assess the changed cell phenotypes and gene expression. RESULTS: @entity9 , @entity10 , and @entity6 were expressed in 61.0%, 77.9%, and 75.6% of @entity2 tissues, respectively. Moreover, @entity9 and @entity10 expression was associated with @entity1 differentiations, advanced clinical stages, lymph node, and distant @entity0 of @entity2 . Similarly, @entity6 expression was associated with @entity9 and @entity10 . Expression of these three proteins was interrelated. In vitro study showed that levels of @entity9 and @entity10 proteins were associated with the capacity of @entity2 cell migration, while knockdown of their expression inhibited @entity2 cell migration and invasion abilities in vitro. In contrast, overexpression of @entity9 and @entity10 proteins promoted @entity1 cell migration and invasion. At the gene levels, knockdown of @entity9 or @entity10 expression suppressed expression of @entity11 , @entity8 , and @entity7 proteins and phosphorylated @entity4 and @entity5 . Conversely, upregulation of @entity9 or @entity10 promoted expression of @entity11 , @entity8 , @entity7 , and @entity4 proteins and phosphorylated @entity7 , @entity4 and @entity5 . CONCLUSIONS: These findings suggest that @entity9 and @entity10 play an important role in @entity2 progression. Further study will be performed to investigate whether target of their expression can be used as a novel strategy in clinical control of @entity2 @entity0 .

title: Association of CXCR1 and 2 expressions with XXXX @entity0 in ex vivo and @entity1 cell invasion in vitro.

answer: @entity2