abstract: BACKGROUND: @entity13 , a new analog of @entity7 , has been developed and marketed in recent years in Japan. In this study, we evaluated the efficacy and @entity3 of a regimen of @entity13 and @entity11 with radiation in @entity0 with advanced @entity5 . MATERIALS AND METHODS: Between June 1999 and December 2002, 42 @entity0 with advanced and unresectable @entity12 ( @entity8 ) were enrolled into this study. Twenty-five of these 42 @entity0 were considered to have inoperable @entity2 due to distant organ @entity1 , distant lymph node @entity1 , severe organ dysfunction and rejection of surgery by the @entity0 . The remaining 17 @entity0 received neoadjuvant treatment followed by surgery. The clinical responses of the @entity2 were evaluated. RESULTS: Response and @entity3 could be assessed in 22 of the 25 @entity0 with unresectable esophageal @entity8 . Two of these 22 achieved a complete response (CR), 15 had a partial response (PR) and 5 showed no change (NC). The overall response rate (CR + PR) was 77%. The one- and 2-year survival rates were 30.7% and 10.2%, respectively, with a @entity9 ( @entity9 ) of 10.1 months. Of the 17 @entity0 who received neoadjuvant treatment, 14 underwent subsequent surgery. Preoperatively, 2 of these 17 @entity0 achieved a CR, 10 had a PR and 5 showed NC. The overall response rate for all 39 @entity0 was 74%. The pathological complete response (pCR) rate of the 14 @entity0 who underwent surgery was 28.6%. Their one- and 2-year survival rates were 48.2% and 12.1%, respectively, with an @entity9 of 12.2 months. @entity3 was evaluated in the 39 @entity0 whose responses were assessed. @entity3 higher than grade 3 occurred in 8 out of 39 (20.5%) @entity0 , and 6 (15.4%), 3 (7.7%) and one (2.6%) had grade 3 @entity10 , @entity6 and @entity4 , respectively. CONCLUSION: In conclusion, this study indicates that combination chemoradiotherapy with @entity13 and @entity11 is safe and efficacious for @entity0 with advanced @entity5 . We recommend further evaluation of this treatment regimen in such @entity0 .

title: Efficacy and @entity3 of @entity13 and @entity11 with radiation treatment for advanced XXXX .

answer: @entity5


abstract: BACKGROUND: @entity13 , a new analog of @entity7 , has been developed and marketed in recent years in Japan. In this study, we evaluated the efficacy and @entity3 of a regimen of @entity13 and @entity11 with radiation in @entity0 with advanced @entity5 . MATERIALS AND METHODS: Between June 1999 and December 2002, 42 @entity0 with advanced and unresectable @entity12 ( @entity8 ) were enrolled into this study. Twenty-five of these 42 @entity0 were considered to have inoperable @entity2 due to distant organ @entity1 , distant lymph node @entity1 , severe organ dysfunction and rejection of surgery by the @entity0 . The remaining 17 @entity0 received neoadjuvant treatment followed by surgery. The clinical responses of the @entity2 were evaluated. RESULTS: Response and @entity3 could be assessed in 22 of the 25 @entity0 with unresectable esophageal @entity8 . Two of these 22 achieved a complete response (CR), 15 had a partial response (PR) and 5 showed no change (NC). The overall response rate (CR + PR) was 77%. The one- and 2-year survival rates were 30.7% and 10.2%, respectively, with a @entity9 ( @entity9 ) of 10.1 months. Of the 17 @entity0 who received neoadjuvant treatment, 14 underwent subsequent surgery. Preoperatively, 2 of these 17 @entity0 achieved a CR, 10 had a PR and 5 showed NC. The overall response rate for all 39 @entity0 was 74%. The pathological complete response (pCR) rate of the 14 @entity0 who underwent surgery was 28.6%. Their one- and 2-year survival rates were 48.2% and 12.1%, respectively, with an @entity9 of 12.2 months. @entity3 was evaluated in the 39 @entity0 whose responses were assessed. @entity3 higher than grade 3 occurred in 8 out of 39 (20.5%) @entity0 , and 6 (15.4%), 3 (7.7%) and one (2.6%) had grade 3 @entity10 , @entity6 and @entity4 , respectively. CONCLUSION: In conclusion, this study indicates that combination chemoradiotherapy with @entity13 and @entity11 is safe and efficacious for @entity0 with advanced @entity5 . We recommend further evaluation of this treatment regimen in such @entity0 .

title: Efficacy and @entity3 of XXXX and @entity11 with radiation treatment for advanced @entity5 .

answer: @entity13


abstract: BACKGROUND: @entity13 , a new analog of @entity7 , has been developed and marketed in recent years in Japan. In this study, we evaluated the efficacy and @entity3 of a regimen of @entity13 and @entity11 with radiation in @entity0 with advanced @entity5 . MATERIALS AND METHODS: Between June 1999 and December 2002, 42 @entity0 with advanced and unresectable @entity12 ( @entity8 ) were enrolled into this study. Twenty-five of these 42 @entity0 were considered to have inoperable @entity2 due to distant organ @entity1 , distant lymph node @entity1 , severe organ dysfunction and rejection of surgery by the @entity0 . The remaining 17 @entity0 received neoadjuvant treatment followed by surgery. The clinical responses of the @entity2 were evaluated. RESULTS: Response and @entity3 could be assessed in 22 of the 25 @entity0 with unresectable esophageal @entity8 . Two of these 22 achieved a complete response (CR), 15 had a partial response (PR) and 5 showed no change (NC). The overall response rate (CR + PR) was 77%. The one- and 2-year survival rates were 30.7% and 10.2%, respectively, with a @entity9 ( @entity9 ) of 10.1 months. Of the 17 @entity0 who received neoadjuvant treatment, 14 underwent subsequent surgery. Preoperatively, 2 of these 17 @entity0 achieved a CR, 10 had a PR and 5 showed NC. The overall response rate for all 39 @entity0 was 74%. The pathological complete response (pCR) rate of the 14 @entity0 who underwent surgery was 28.6%. Their one- and 2-year survival rates were 48.2% and 12.1%, respectively, with an @entity9 of 12.2 months. @entity3 was evaluated in the 39 @entity0 whose responses were assessed. @entity3 higher than grade 3 occurred in 8 out of 39 (20.5%) @entity0 , and 6 (15.4%), 3 (7.7%) and one (2.6%) had grade 3 @entity10 , @entity6 and @entity4 , respectively. CONCLUSION: In conclusion, this study indicates that combination chemoradiotherapy with @entity13 and @entity11 is safe and efficacious for @entity0 with advanced @entity5 . We recommend further evaluation of this treatment regimen in such @entity0 .

title: Efficacy and @entity3 of @entity13 and XXXX with radiation treatment for advanced @entity5 .

answer: @entity11


abstract: BACKGROUND: @entity1 rarely affects the genitourinary tract. We present a case of @entity1 of the female urethra and review the associated literature to evaluate the management and prognosis. MATERIALS AND RESULTS: A 69-year-old @entity0 presented with a 3-month history of @entity3 and a red mass at the external urethra without @entity2 . Pathological examination revealed @entity1 . She was treated with excision of the mass and chemotherapy. Six months later she showed no urethral or other recurrence. An additional 17 cases similar to this one were found in the literature. The one-year survival rate was 91% for local stage and less than 35% for disseminated stage. A significant difference was observed between survival rates (log rank test; p = 0.013). CONCLUSION: It appears that therapy including excision, radiation and chemotherapy is effective for @entity0 with local stage but not for @entity0 with disseminated stage.

title: Primary XXXX of the female urethra.

answer: @entity1


abstract: BACKGROUND: @entity8 is one of the less common @entity1 of the lung and is composed of a mixture of malignant epithelial and mesenchymal elements of the type ordinarily seen in @entity1 of adults. The @entity7 component is mostly epidermoid and sometimes adenomatoid or undifferentiated. The mesenchymal part is mostly a spindle cell @entity3 and sometimes a polymorphocellular @entity3 . Differentiation as @entity4 and @entity5 is rare. CASE REPORT: This report describes the case of a @entity0 with @entity8 of the lung composed of @entity6 and @entity5 . A left hilar mass was incidentally diagnosed. The @entity0 was submitted to surgical exploration and a left lower lobectomy with dissection of local lymph nodes was performed. At microscopy the @entity1 was composed of both epithelial and stromal malignant component. The epithelial component consisted of poorly-differentiated @entity6 and the stromal component consisted of @entity5 . He remains well 30 months later. CONCLUSION: The prognosis of @entity0 with @entity8 is not always unfavourable. Potentially curative surgical resections should always be attempted. Pathologists should be aware of a wrong diagnosis of undifferentiated @entity2 which eliminates the @entity0 from surgery.

title: Squamocellular carcinoma and XXXX : a true pulmonary carcinosarcoma. Report of a case.

answer: @entity5


abstract: BACKGROUND: The majority of @entity12 are @entity10 . Ocular involvement by @entity7 is rare. We report a case of @entity8 due to direct involvement of the corneal limbus by @entity6 in a @entity0 with S  zary syndrome. METHODS: A 58-year-old male with @entity7 presented with @entity2 , left-sided corneal ulceration, a dense infiltrate, severe epitheliopathy, hypopyon and a diffuse confluent @entity11 involving the lids. He had a history of S  zary syndrome. Despite maximal treatment, this severe @entity16 progressed to central @entity8 . The eye was subsequently enucleated and submitted for histopathological examination. RESULTS: Histopathological examination confirmed corneal ulceration with perforation. There was an infiltrate of large atypical cells at the limbus, with tropism for the overlying epithelium. Immunohistochemical staining of these cells was positive for @entity15 , CD3, @entity19 , @entity4 and @entity17 . Staining for @entity5 , @entity18 and @entity13 was negative. The appearances were those of an epitheliotrophic @entity7 , and were considered to represent spread from the @entity0 's underlying S  zary syndrome. The @entity0 died 2  months later from @entity14 . CONCLUSIONS: Ocular involvement by @entity7 usually occurs in @entity9 , and carries a poor prognosis. This @entity0 was immunocompromised due to advanced @entity1 , and there was a high suspicion of @entity3 as the primary cause of corneal ulceration. This case highlights that it is important to consider @entity1 as an initiating or contributing factor for corneal ulceration in such @entity0 .

title: XXXX due to limbal involvement in S  zary syndrome.

answer: @entity8


abstract: OBJECTIVE: The objective of this prospective randomized controlled study was to investigate the effect of nutritional supplementation on postoperative oxidative stress and duration of hospitalization in elderly @entity0 with @entity1 . METHODS: A total of fourteen @entity0 (= SG) with @entity1 received individually adapted supplements enriched with protein and antioxidants postoperatively, nine served as unsupplemented controls (= CG). Blood samples were taken preoperatively (T1), on the day of discharge from hospital (T2) and three weeks thereafter (T3). Plasma concentrations of albumin and total protein (TP) were measured by autoanalysis, advanced oxidation protein products (AOPP) and the total antioxidant capacity (TAC) were determined photometrically. @entity2 ( @entity3 ) levels were analyzed by HPLC. RESULTS: Postoperatively, there was a significant (T1 > T2, p< 0.01) decrease in plasma albumin, TP and TAC, followed by a significant (p< 0.05) increase in the period T2-T3 in the CG, but not in the SG. This resulted in significant differences in TP (T2: SG > CG, p< 0.05) and TAC (T2: SG > CG, p< 0.01) between the investigated groups. Postoperatively, the plasma levels of AOPP and @entity3 increased significantly (T1 < T2, p< 0.01) in both groups, and remained at the significantly (AOPP: T1 < T3, p< 0.05; @entity3 : T1 < T3, p< 0.01) elevated level in the CG, but not in the SG (T2 > T3, p< 0.01). Consequently, the oxidant markers @entity3 and AOPP were significantly positively (p< 0.01), TAC and albumin significantly negatively (p< 0.05) related to duration of hospital stay in both groups. CONCLUSIONS: Individualized nutritional supplementation may reduce postoperative oxidative stress and shorten duration of hospitalization in @entity0 with @entity1 .

title: Nutritional supplementation affects postoperative oxidative stress and duration of hospitalization in @entity0 with XXXX .

answer: @entity1


abstract: OBJECTIVE: The objective of this prospective randomized controlled study was to investigate the effect of nutritional supplementation on postoperative oxidative stress and duration of hospitalization in elderly @entity0 with @entity1 . METHODS: A total of fourteen @entity0 (= SG) with @entity1 received individually adapted supplements enriched with protein and antioxidants postoperatively, nine served as unsupplemented controls (= CG). Blood samples were taken preoperatively (T1), on the day of discharge from hospital (T2) and three weeks thereafter (T3). Plasma concentrations of albumin and total protein (TP) were measured by autoanalysis, advanced oxidation protein products (AOPP) and the total antioxidant capacity (TAC) were determined photometrically. @entity2 ( @entity3 ) levels were analyzed by HPLC. RESULTS: Postoperatively, there was a significant (T1 > T2, p< 0.01) decrease in plasma albumin, TP and TAC, followed by a significant (p< 0.05) increase in the period T2-T3 in the CG, but not in the SG. This resulted in significant differences in TP (T2: SG > CG, p< 0.05) and TAC (T2: SG > CG, p< 0.01) between the investigated groups. Postoperatively, the plasma levels of AOPP and @entity3 increased significantly (T1 < T2, p< 0.01) in both groups, and remained at the significantly (AOPP: T1 < T3, p< 0.05; @entity3 : T1 < T3, p< 0.01) elevated level in the CG, but not in the SG (T2 > T3, p< 0.01). Consequently, the oxidant markers @entity3 and AOPP were significantly positively (p< 0.01), TAC and albumin significantly negatively (p< 0.05) related to duration of hospital stay in both groups. CONCLUSIONS: Individualized nutritional supplementation may reduce postoperative oxidative stress and shorten duration of hospitalization in @entity0 with @entity1 .

title: Nutritional supplementation affects postoperative oxidative stress and duration of hospitalization in XXXX with @entity1 .

answer: @entity0


abstract: OBJECTIVES: Although the importance of stretching exercise for @entity1 -relieving and @entity0 education is well documented for chronic lumbago @entity0 , it is uncertain how effective on-the-job training (OJT) is for female caregivers in nursing homes. In the present pilot trial based on multicenter randomization, we evaluated the intervention effect of a lecture and stretching exercise on caregivers in nursing homes. METHODS: Eighty-eight female caregivers (four nursing homes) volunteered to participate in this study, and they were separated into two groups randomly. For the intervention group, guidance by an orthopedist and an exercise instructor were provided as one OJT, and stretching exercises for only 6 min every day were recommended for @entity2 prevention to the caregivers. @entity2 visual analogue scale (VAS), physical fitness, and mental and physical health were compared at baseline and immediately after the intervention. RESULTS: A total of 29 (33%) @entity0 withdrew by 12 weeks. Regarding the reasons for withdrawal, 28 @entity0 resigned, and one took a leave of absence due to exacerbation of lumbago. Adherence to the stretching exercises was 2.3    1.3 (mean    SD) times per week. No significant differences were seen for any outcome measurements. The high adherence group (   3 times per week) did not show a change in the VAS, but the low adherence group (<3 times per week) and control group showed a tendency towards an increased score (p = 0.068). CONCLUSIONS: Even with the conduct of one OJT, and exercises of only 6 min every day, the adherence of caregivers was low, and there appeared to be few effects of the OJT.

title: Effectiveness of intervention for XXXX in female caregivers in nursing homes: a pilot trial based on multicenter randomization.

answer: @entity2


abstract: OBJECTIVES: The purposes of this paper were to evaluate the serum @entity1 levels in healthy adolescents and to establish standard age variation curves. METHODS: Nine hundred six (414 @entity0 and 492 @entity0 ) healthy adolescents were investigated. The maximum increment age in height (MIA) was identified in 124 @entity0 and 130 @entity0 . The menarcheal age (MA) was obtained for 130 @entity0 . Fasting @entity1 levels were measured by enzyme immunoassay. The MIA was calculated by proportional allotment of yearly height increments. RESULTS: Serum @entity1 levels did not change in @entity0 and @entity0 from the ages of 9 to 11. They decreased after the age of 11 in @entity0 , while they increased in @entity0 . Stepwise multiple regression analysis revealed that serum @entity1 levels were closely related to pubertal stage. The levels decreased remarkably after MIA in @entity0 and increased remarkably after MA in @entity0 . We drew standard age variation curves of serum @entity1 levels by calculating the 25th, 50th and 75th percentiles for each age in both @entity0 and @entity0 . The percentile curves for @entity0 were divided into pre-MIA and post-MIA curves. Those for @entity0 were divided into pre-MA and post-MA curves. CONCLUSION: We have devised a potentially useful method for evaluating serum @entity1 levels in adolescents considering the effects of gender and growth.

title: Serum XXXX levels in healthy adolescents: Effects of gender and growth.

answer: @entity1


abstract: OBJECTIVE: To identify apoptosis in @entity5 intestines and determine whether apoptosis is associated with @entity3 or a specific tissue layer of intestine. ANIMALS: 38 @entity5 that underwent surgery or were euthanatized for small or large @entity4 and 9 control @entity5 euthanatized for reasons other than @entity3 or @entity2 . PROCEDURE: Specimens were collected at surgery from intestine involved in the @entity1 and distant to the @entity1 site or at necropsy from several sites including the @entity1 site. Histologic tissue sections were stained with H_E, and apoptosis was detected by use of the terminal deoxynucleotidyl transferase-mediated @entity6 nick end labeling technique. The number of apoptotic cells per hpf was counted in the mucosa, circular muscle, longitudinal muscle, and serosa. RESULTS: Apoptotic nuclei were seen in all layers of intestine. An increased number of apoptotic cells was found in the circular muscle of the intestine from @entity5 with simple obstruction, compared with strangulating obstruction or healthy intestine. Intestine distant from a primary strangulating lesion had higher numbers of apoptotic cells than did intestine distant from a @entity1 or intestine taken at the site of a strangulating or @entity1 . CONCLUSIONS AND CLINICAL RELEVANCE: Intestine from @entity5 with obstructing or strangulating lesions in the small intestine and large colon had high numbers of apoptotic cells possibly because of @entity7 and subsequent @entity0 . Whether substantial apoptosis affects intestinal function is not yet known.

title: Detection of apoptotic cells in intestines from @entity5 with and without XXXX .

answer: @entity3


abstract: OBJECTIVE: To identify apoptosis in @entity5 intestines and determine whether apoptosis is associated with @entity3 or a specific tissue layer of intestine. ANIMALS: 38 @entity5 that underwent surgery or were euthanatized for small or large @entity4 and 9 control @entity5 euthanatized for reasons other than @entity3 or @entity2 . PROCEDURE: Specimens were collected at surgery from intestine involved in the @entity1 and distant to the @entity1 site or at necropsy from several sites including the @entity1 site. Histologic tissue sections were stained with H_E, and apoptosis was detected by use of the terminal deoxynucleotidyl transferase-mediated @entity6 nick end labeling technique. The number of apoptotic cells per hpf was counted in the mucosa, circular muscle, longitudinal muscle, and serosa. RESULTS: Apoptotic nuclei were seen in all layers of intestine. An increased number of apoptotic cells was found in the circular muscle of the intestine from @entity5 with simple obstruction, compared with strangulating obstruction or healthy intestine. Intestine distant from a primary strangulating lesion had higher numbers of apoptotic cells than did intestine distant from a @entity1 or intestine taken at the site of a strangulating or @entity1 . CONCLUSIONS AND CLINICAL RELEVANCE: Intestine from @entity5 with obstructing or strangulating lesions in the small intestine and large colon had high numbers of apoptotic cells possibly because of @entity7 and subsequent @entity0 . Whether substantial apoptosis affects intestinal function is not yet known.

title: Detection of apoptotic cells in intestines from XXXX with and without @entity3 .

answer: @entity5


abstract: BACKGROUND: The type of surgical antimicrobial prophylaxis (SAP) is determined by the spectrum and antimicrobial resistance of pathogens causing surgical site @entity2 (SSI). The aim of this study was to define the microbiological features of SSI in general surgery @entity0 at Basel University Hospital in order to validate our current strategy of single-shot SAP with 1.5 g @entity6 (plus 500 mg @entity5 in colorectal surgery). METHODS: A prospective observational cohort of consecutive vascular, visceral and @entity1 procedures was analysed to evaluate the incidence of SSI. @entity7 and resulting @entity2 were assessed to centres for disease control standards. Microbiological evaluation was performed by microscopic direct preparation, cultures and testing for antibiotic resistance. RESULTS: A total of 293 instances of SSI were detected in this cohort of 6283 surgical procedures (4.7%). Microbiological species were identified in 129 of 293 SSI (44%). @entity4 (29.5%) was the most common pathogen causing SSI in @entity1 and vascular surgery, whereas @entity3 (20.9%) was more frequently responsible for SSI in visceral surgery. Importantly, not a single case of SSI was caused by antimicrobial-resistant pathogens in this series. CONCLUSIONS: The spectrum of pathogens causing SSI identified and the very low incidence of antimicrobial resistance at Basel University Hospital validate the continuous use of single-shot single-drug SAP with @entity6 (plus @entity5 in colorectal surgery).

title: Spectrum of pathogens in surgical site XXXX at a Swiss university hospital.

answer: @entity2


abstract: BACKGROUND: Palliative resection of the primary @entity1 in asymptomatic @entity0 with stage IV @entity2 is associated with improved survival and fewer complications. Laparoscopic surgery is widely employed in the curative treatment of @entity2 , but its value in advanced @entity2 remains unclear. METHODS: All @entity0 who underwent laparoscopic resection of primary @entity2 in this unit between June 1991 and Jan 2010 were entered into a prospective computerized database. Outcomes for @entity0 with laparoscopic resection of stage IV @entity2 were compared with those of @entity0 who had laparoscopic surgery for stage I disease. RESULTS: Some 185 @entity0 with stage IV @entity2 who underwent laparoscopic resection were compared with 310 @entity0 who had stage I @entity2 . Some 94  1 and 98  4 per cent of operations respectively were completed laparoscopically. Hospital stay was slightly longer in the group with stage IV disease (mean 6  2 versus 5  3 days; P = 0  091). The 30-day mortality rate was 2  7 per cent in @entity0 with stage IV disease and 0  6 per cent in those with @entity1 (P = 0  061). There was no difference in complications. One-year survival rates were 77  8 and 99  0 per cent respectively (P < 0  001). CONCLUSION: Short-term outcomes after laparoscopic surgery for stage IV @entity2 in selected @entity0 are equivalent to those for @entity1 .

title: Laparoscopic resection of advanced XXXX .

answer: @entity2


abstract: OBJECTIVE: To examine the role of mast cells (MCs), cytokines, and matrix metalloproteinases (MMPs) following ultraviolet B (UVB) radiation in @entity4 ( @entity4 ). METHODS: Immunohistochemistry was used to determine the presence of MCs and the expression of @entity3 , @entity2 , @entity6 , and @entity5 / @entity5 in skin from @entity0 with @entity4 . @entity0 keratinocytes were exposed to varying doses of UVB and supernatants were collected and assessed for @entity6 , @entity5 , @entity3 , and @entity2 by protein assays. MC migration was determined against supernatants from UVB-treated keratinocytes. RESULTS: MCs in the skin of @entity0 with @entity4 were significantly increased. @entity3 and @entity2 expression was abundant in these lesions. Intense reactivity for @entity6 and @entity5 was found in skin, particularly in epidermal keratinocytes, from @entity0 with @entity4 . UVB irradiation induced @entity6 , @entity5 , @entity3 , and @entity2 production from keratinocytes in a dose- and time-dependent manner. Supernatants obtained from UVB-treated keratinocytes induced MC migration, which was attenuated by anti- @entity6 and anti- @entity5 neutralizing antibodies. @entity6 induced MC-derived MMP production. CONCLUSIONS: Our results indicate that MCs and MMPs may play a role in the @entity1 in @entity4 . MC recruitment as well as MMP production may be perpetuated by UV irradiation through locally released mediators.

title: Ultraviolet radiation-induced cytokines promote mast cell accumulation and matrix metalloproteinase production: potential role in XXXX .

answer: @entity4


abstract: BACKGROUND: Although crustaceans have been reported to be one of the most common causes of IgE-mediated @entity0 , there are no reports about the characterization and identification of @entity1 kinase ( @entity6 ) from the @entity4 ( @entity4 ) as allergen. In the present study, the purification, molecular cloning, expression and immunological analyses of the IgE allergen @entity6 from the @entity4 were investigated. RESULTS: The results showed that cloned DNA fragments of @entity6 from the @entity4 had open reading frames of 1021 bp, predicted to encode proteins with 356 @entity2 residues. Sequence alignment revealed that @entity4 @entity6 shares high homology with other crustacean species. @entity4 @entity6 gene was further recombined with the vector of pGEX-4T-3 and expressed in @entity5 . 2-D electrophoresis suggested that native @entity6 (nAK) and recombinant @entity6 ( @entity6 ) shared the same molecular weight of 40 kDa, and the pI is 6.5 and 6.3, respectively. The nAK and @entity6 were further confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Immunoblotting analysis and colloidal gold immunochromatographic assay (GICA) using sera from subjects with crustacean @entity3 confirmed that the nAK and @entity6 reacted positively with these sera, indicating @entity6 is a specific allergen of @entity4 . CONCLUSION: Both of purified nAK and @entity6 reacted positively with sera from subjects with crustacean @entity3 in immunoblotting and GICA analysis, indicating @entity6 is a common allergen of @entity4 . In vitro expressed @entity6 is proposed as a source of the protein for immunological or clinical studies.

title: Purification, cloning, expression and immunological analysis of XXXX @entity1 kinase, the crab allergen.

answer: @entity4


abstract: BACKGROUND: Although crustaceans have been reported to be one of the most common causes of IgE-mediated @entity0 , there are no reports about the characterization and identification of @entity1 kinase ( @entity6 ) from the @entity4 ( @entity4 ) as allergen. In the present study, the purification, molecular cloning, expression and immunological analyses of the IgE allergen @entity6 from the @entity4 were investigated. RESULTS: The results showed that cloned DNA fragments of @entity6 from the @entity4 had open reading frames of 1021 bp, predicted to encode proteins with 356 @entity2 residues. Sequence alignment revealed that @entity4 @entity6 shares high homology with other crustacean species. @entity4 @entity6 gene was further recombined with the vector of pGEX-4T-3 and expressed in @entity5 . 2-D electrophoresis suggested that native @entity6 (nAK) and recombinant @entity6 ( @entity6 ) shared the same molecular weight of 40 kDa, and the pI is 6.5 and 6.3, respectively. The nAK and @entity6 were further confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Immunoblotting analysis and colloidal gold immunochromatographic assay (GICA) using sera from subjects with crustacean @entity3 confirmed that the nAK and @entity6 reacted positively with these sera, indicating @entity6 is a specific allergen of @entity4 . CONCLUSION: Both of purified nAK and @entity6 reacted positively with sera from subjects with crustacean @entity3 in immunoblotting and GICA analysis, indicating @entity6 is a common allergen of @entity4 . In vitro expressed @entity6 is proposed as a source of the protein for immunological or clinical studies.

title: Purification, cloning, expression and immunological analysis of @entity4 XXXX kinase, the crab allergen.

answer: @entity1


abstract: BACKGROUND: In the emergency management of @entity0 with @entity1 , there is ongoing debate about the roles of angiography and open pelvic packing. It is agreed that some form of @entity2 control is required for @entity0 who are haemo-dynamically unstable despite resuscitation. We set out to determine whether on-call general and orthopaedic surgeons would feel able to perform emergency surgical procedures for these @entity0 and whether vascular radiology was available to them. METHODS: Surveys were sent to all 221 general and orthopaedic surgeons in Wales. Questions included: sub-speciality interest, geographical region, whether there is a pelvic binder in their hospital, availability of interventional radiology, and whether surgeons would perform a range of procedures to control @entity2 in the emergency setting. RESULTS: There were 141 responses to the survey, giving a 64% response rate. Only 18% reported that their unit had a formal rota for interventional radiology out of hours. 16% did not know. 96% of orthopaedic surgeons would perform external fixation, although only 49% would use a C-clamp. 90% of general surgeons would be able to pack the pelvis from within the abdominal compartment and 84% would be prepared to cross-clamp the aorta if the situation required. Despite being widely recommended in the literature as a method of @entity2 control, our survey revealed only 45% would perform extra(pre)-peritoneal packing of the pelvis (58% of general surgeons; 34% of orthopaedic surgeons) and only 12% had received formal training in this procedure. CONCLUSIONS: With appropriately targeted training it is likely that the care of @entity0 with @entity1 can be significantly improved.

title: XXXX control in @entity1 --a survey of surgical capabilities.

answer: @entity2


abstract: BACKGROUND: In the emergency management of @entity0 with @entity1 , there is ongoing debate about the roles of angiography and open pelvic packing. It is agreed that some form of @entity2 control is required for @entity0 who are haemo-dynamically unstable despite resuscitation. We set out to determine whether on-call general and orthopaedic surgeons would feel able to perform emergency surgical procedures for these @entity0 and whether vascular radiology was available to them. METHODS: Surveys were sent to all 221 general and orthopaedic surgeons in Wales. Questions included: sub-speciality interest, geographical region, whether there is a pelvic binder in their hospital, availability of interventional radiology, and whether surgeons would perform a range of procedures to control @entity2 in the emergency setting. RESULTS: There were 141 responses to the survey, giving a 64% response rate. Only 18% reported that their unit had a formal rota for interventional radiology out of hours. 16% did not know. 96% of orthopaedic surgeons would perform external fixation, although only 49% would use a C-clamp. 90% of general surgeons would be able to pack the pelvis from within the abdominal compartment and 84% would be prepared to cross-clamp the aorta if the situation required. Despite being widely recommended in the literature as a method of @entity2 control, our survey revealed only 45% would perform extra(pre)-peritoneal packing of the pelvis (58% of general surgeons; 34% of orthopaedic surgeons) and only 12% had received formal training in this procedure. CONCLUSIONS: With appropriately targeted training it is likely that the care of @entity0 with @entity1 can be significantly improved.

title: @entity2 control in XXXX --a survey of surgical capabilities.

answer: @entity1


abstract: Despite its prevalence, clinical and prognostic impact, @entity4 , is widely under-diagnosed. The need for training and expertise to perform the cardiovascular tests (usually the task of diabetologists) is one possible reason. The availability of computer-assisted systems has allowed a wider diffusion of testing, but has also highlighted the need for an adequate knowledge of physiopathological backgrounds for their correct application and interpretation. The recommendations presented here were developed by the @entity1 Study Group of the Italian Society of Diabetology and then endorsed by the Italian Association for the Study of Neurovegetative System, to promote the widespread adoption of good clinical practice in @entity2 autonomic testing by outlining main evidence-based aspects, i.e. which tests, how to perform them, adequate interpretation of the results and their diagnostic use, confounding conditions that can impact on tests reliability. Therefore, these recommendations include the essential aspects of the physiopathological substrate of the tests, the controversial points in their analysis, their diagnostic characteristics, as well as safety. Detailed information is given on the physiological (age, weight, body position, resting heart rate and blood pressure, respiratory pattern, exercise, meals, acute blood @entity3 changes) and pathophysiological confounding factors, with emphasis on the effects of drugs. Instructions on how to perform the tests and interpret their results are also considered together with indications of candidate @entity0 and periodicity of testing. A @entity0 instruction sheet on why and how to perform the tests is included. Finally, the specific requirements for computerized systems to perform and evaluate cardiovascular tests are provided.

title: Recommendations for the use of cardiovascular tests in diagnosing XXXX .

answer: @entity4


abstract: BACKGROUND: @entity3 is a personality trait reflecting the tendency to experience negative affect. It is a major risk for psychopathology, especially @entity2 and @entity1 . Childhood maltreatment is another major risk factor for psychopathology and may influence personality. Maltreatment may interact with genotype to predict developmental outcomes. Variation in three polymorphisms of the @entity4 gene has been found to moderate the association of childhood maltreatment with @entity2 , and we hypothesized that it would also be linked to @entity3 . METHODS: Variation in three @entity4 SNPs ( @entity6 , @entity7 , @entity5 ) was assessed in 339 maltreated and 275 demographically similar nonmaltreated @entity0 , who participated in a day camp research program. Maltreated @entity0 were further categorized based on the number of types of maltreatment they had experienced and the most severe form of maltreatment experienced. Genotype and maltreatment status were used to predict the Big Five personality traits, as assessed by camp counselors following a week of interaction with @entity0 . RESULTS:     @entity4 genotype significantly moderated the association of maltreatment with @entity3 but none of the other traits. Having two copies of the TAT haplotype of @entity4 was associated with higher levels of @entity3 among maltreated @entity0 relative to nonmaltreated @entity0 , with the exception of sexually abused @entity0 and @entity0 who had experienced 3 or 4 types of abuse. Effects sizes of these interactions ranged from   2=.01 (p=.02) to   2=.03 (p=.006). CONCLUSIONS: Variation in @entity4 moderates the association of maltreatment with @entity3 . The effects of specific types of maltreatment on @entity3 are differentially moderated by @entity4 genotype, as are the effects of experiencing more or fewer types of maltreatment.

title: Moderation of the association between childhood maltreatment and @entity3 by the XXXX gene.

answer: @entity4


abstract: BACKGROUND: @entity3 is a personality trait reflecting the tendency to experience negative affect. It is a major risk for psychopathology, especially @entity2 and @entity1 . Childhood maltreatment is another major risk factor for psychopathology and may influence personality. Maltreatment may interact with genotype to predict developmental outcomes. Variation in three polymorphisms of the @entity4 gene has been found to moderate the association of childhood maltreatment with @entity2 , and we hypothesized that it would also be linked to @entity3 . METHODS: Variation in three @entity4 SNPs ( @entity6 , @entity7 , @entity5 ) was assessed in 339 maltreated and 275 demographically similar nonmaltreated @entity0 , who participated in a day camp research program. Maltreated @entity0 were further categorized based on the number of types of maltreatment they had experienced and the most severe form of maltreatment experienced. Genotype and maltreatment status were used to predict the Big Five personality traits, as assessed by camp counselors following a week of interaction with @entity0 . RESULTS:     @entity4 genotype significantly moderated the association of maltreatment with @entity3 but none of the other traits. Having two copies of the TAT haplotype of @entity4 was associated with higher levels of @entity3 among maltreated @entity0 relative to nonmaltreated @entity0 , with the exception of sexually abused @entity0 and @entity0 who had experienced 3 or 4 types of abuse. Effects sizes of these interactions ranged from   2=.01 (p=.02) to   2=.03 (p=.006). CONCLUSIONS: Variation in @entity4 moderates the association of maltreatment with @entity3 . The effects of specific types of maltreatment on @entity3 are differentially moderated by @entity4 genotype, as are the effects of experiencing more or fewer types of maltreatment.

title: Moderation of the association between childhood maltreatment and XXXX by the @entity4 gene.

answer: @entity3


abstract: BACKGROUND: Admission with a multidisciplinary @entity1 team may be vital for the severely injured @entity0 , as this facilitates rapid diagnosis and treatment. On the other hand, @entity0 with minor injuries do not need the @entity1 team for adequate care. Correct triage is important for optimal resource utilization. The aim of the study was to evaluate our criteria for activating the @entity1 team, and identify suboptimal criteria that might be changed in the interest of precision. METHODS: The study is an observational, retrospective cohort-study. All @entity0 admitted with the @entity1 team (n = 382), all severely injured (Injury Severity Score (ISS) >15) (n = 161), and all undergoing an emergency procedure aimed at counteracting compromised airways, respiration or circulation at our hospital (n = 142) during 2006-2007 were included. Data were recorded from the admission records and the electronic @entity0 records. The @entity1 team activation protocol was evaluated against the occurrence of severe injury and the occurrence of emergency procedures. RESULTS: A total of 441 @entity0 were included. The overtriage was 71% and undertriage 32% when evaluating against ISS >15 as the standard of reference. When occurrence of emergency procedures was held as the standard of standard of reference, the over- and undertriage was 71% and 21%, respectively. Mechanism of injury-criteria for @entity1 team activation contributed the most to overtriage. The emergency procedures performed were mostly endotracheal intubation and external fixation of @entity2 . Less than 3% needed haemostatic laparotomy or thoracotomy. Approximately 2/3 of the overtriage represented isolated head or cervical spine injuries, and/or interhospital transfers. CONCLUSIONS: The over- and undertriage of our protocol are both too high. To decrease overtriage we suggest omissions and modifications of some of the criteria. To decrease undertriage, transferred @entity0 and @entity0 with @entity3 should be more thoroughly assessed against the @entity1 team activation criteria.

title: Evaluation of a university hospital XXXX team activation protocol.

answer: @entity1


abstract: Several inflammatory markers have been investigated as prognostic parameters in a variety of @entity1 population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic @entity3 score (PIS) could further improve their prognostic values in surgical @entity0 with @entity2 ( @entity2 ). A total of 265 @entity0 who had undergone curative resection of @entity2 were reviewed retrospectively. Preoperative levels of inflammatory markers such as serum @entity5 ( @entity5 ), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and neutrophil/lymphocyte ratio (NLR) were assessed by uni- and multivariate survival analysis with disease-free (DFS) and @entity4 ( @entity4 ). PIS was constructed with a selective combination of inflammatory markers which were independently significant. On univariate analysis, @entity5 , ESR, and NLR were significantly associated with DFS and @entity4 . On multivariate analysis, @entity5 and NLR were independently significant prognostic variables for @entity4 and DFS respectively (P=0.013, P=0.021). When PIS was constructed with combination of @entity5 and NLR, it was independently and significantly associated with both DFS and @entity4 (P=0.006, P=0.010). Furthermore, PIS was superior to @entity5 for @entity4 (HR=15.679 vs. HR=5.183), and NLR for DFS in terms of prognosticating power (HR=4.894 vs. HR=2.687). When PIS is constructed with combination of @entity5 and NLR, it is a potentially significant prognostic variable associated with poor survival regardless pathologic prognostic variables in @entity0 with @entity2 after curative resection.

title: @entity3 Score in Surgical @entity0 with XXXX .

answer: @entity2


abstract: Several inflammatory markers have been investigated as prognostic parameters in a variety of @entity1 population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic @entity3 score (PIS) could further improve their prognostic values in surgical @entity0 with @entity2 ( @entity2 ). A total of 265 @entity0 who had undergone curative resection of @entity2 were reviewed retrospectively. Preoperative levels of inflammatory markers such as serum @entity5 ( @entity5 ), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and neutrophil/lymphocyte ratio (NLR) were assessed by uni- and multivariate survival analysis with disease-free (DFS) and @entity4 ( @entity4 ). PIS was constructed with a selective combination of inflammatory markers which were independently significant. On univariate analysis, @entity5 , ESR, and NLR were significantly associated with DFS and @entity4 . On multivariate analysis, @entity5 and NLR were independently significant prognostic variables for @entity4 and DFS respectively (P=0.013, P=0.021). When PIS was constructed with combination of @entity5 and NLR, it was independently and significantly associated with both DFS and @entity4 (P=0.006, P=0.010). Furthermore, PIS was superior to @entity5 for @entity4 (HR=15.679 vs. HR=5.183), and NLR for DFS in terms of prognosticating power (HR=4.894 vs. HR=2.687). When PIS is constructed with combination of @entity5 and NLR, it is a potentially significant prognostic variable associated with poor survival regardless pathologic prognostic variables in @entity0 with @entity2 after curative resection.

title: XXXX Score in Surgical @entity0 with @entity2 .

answer: @entity3


abstract: Several inflammatory markers have been investigated as prognostic parameters in a variety of @entity1 population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic @entity3 score (PIS) could further improve their prognostic values in surgical @entity0 with @entity2 ( @entity2 ). A total of 265 @entity0 who had undergone curative resection of @entity2 were reviewed retrospectively. Preoperative levels of inflammatory markers such as serum @entity5 ( @entity5 ), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and neutrophil/lymphocyte ratio (NLR) were assessed by uni- and multivariate survival analysis with disease-free (DFS) and @entity4 ( @entity4 ). PIS was constructed with a selective combination of inflammatory markers which were independently significant. On univariate analysis, @entity5 , ESR, and NLR were significantly associated with DFS and @entity4 . On multivariate analysis, @entity5 and NLR were independently significant prognostic variables for @entity4 and DFS respectively (P=0.013, P=0.021). When PIS was constructed with combination of @entity5 and NLR, it was independently and significantly associated with both DFS and @entity4 (P=0.006, P=0.010). Furthermore, PIS was superior to @entity5 for @entity4 (HR=15.679 vs. HR=5.183), and NLR for DFS in terms of prognosticating power (HR=4.894 vs. HR=2.687). When PIS is constructed with combination of @entity5 and NLR, it is a potentially significant prognostic variable associated with poor survival regardless pathologic prognostic variables in @entity0 with @entity2 after curative resection.

title: @entity3 Score in Surgical XXXX with @entity2 .

answer: @entity0


abstract: OBJECTIVES: To evaluate the prognostic effect of age in @entity0 with @entity2 ( @entity2 ) and investigate the incidence of Xp11 translocation @entity2 in young @entity0 who developed recurrence. METHODS: From 1990 to 2007, 2403 Japanese @entity0 underwent nephrectomy for presumed @entity2 at 9 institutions. Of those, 1143 @entity0 had localized @entity2 (Stage pT1-2N0M0). Their clinical data were retrospectively reviewed. In the present study, 131 @entity0 (11%) were considered young ( <=45 years at diagnosis). In the young @entity0 with recurrence, the nephrectomy specimens were immunostained with @entity3 to determine the incidence of Xp11 translocation @entity2 . RESULTS: During the median follow-up of 47 months, 3 @entity1 deaths (2.2%) occurred among young @entity0 and 51 (5.0%) among older @entity0 . The 5-year @entity1 -specific survival (CSS) rate was significantly better for the younger @entity0 than for the older @entity0 (P = .049). Multivariate analysis showed that age was significantly associated with CSS, as were the pathologic T stage, @entity1 grade, and symptoms at diagnosis. The hazard ratio of young age was 0.31 (95% confidence interval 0.077-0.87). The recurrence-free survival curves revealed no difference between these 2 groups. Of the 74 @entity0 with recurrence, the CSS after recurrence was significantly better in the younger @entity0 than in the older @entity0 (P = .0010). Of the 8 young @entity0 with recurrence, 4 had Xp11 translocation @entity2 , and 3 survived for >5 years after recurrence. CONCLUSIONS: Compared with the older @entity0 , the young @entity0 with @entity2 had similar recurrence-free survival rates but better CSS rates. This might have been because significant numbers of the young @entity0 had Xp11 translocation @entity2 .

title: Young age as favorable prognostic factor for @entity1 -specific survival in XXXX .

answer: @entity2


abstract: OBJECTIVES: To evaluate the prognostic effect of age in @entity0 with @entity2 ( @entity2 ) and investigate the incidence of Xp11 translocation @entity2 in young @entity0 who developed recurrence. METHODS: From 1990 to 2007, 2403 Japanese @entity0 underwent nephrectomy for presumed @entity2 at 9 institutions. Of those, 1143 @entity0 had localized @entity2 (Stage pT1-2N0M0). Their clinical data were retrospectively reviewed. In the present study, 131 @entity0 (11%) were considered young ( <=45 years at diagnosis). In the young @entity0 with recurrence, the nephrectomy specimens were immunostained with @entity3 to determine the incidence of Xp11 translocation @entity2 . RESULTS: During the median follow-up of 47 months, 3 @entity1 deaths (2.2%) occurred among young @entity0 and 51 (5.0%) among older @entity0 . The 5-year @entity1 -specific survival (CSS) rate was significantly better for the younger @entity0 than for the older @entity0 (P = .049). Multivariate analysis showed that age was significantly associated with CSS, as were the pathologic T stage, @entity1 grade, and symptoms at diagnosis. The hazard ratio of young age was 0.31 (95% confidence interval 0.077-0.87). The recurrence-free survival curves revealed no difference between these 2 groups. Of the 74 @entity0 with recurrence, the CSS after recurrence was significantly better in the younger @entity0 than in the older @entity0 (P = .0010). Of the 8 young @entity0 with recurrence, 4 had Xp11 translocation @entity2 , and 3 survived for >5 years after recurrence. CONCLUSIONS: Compared with the older @entity0 , the young @entity0 with @entity2 had similar recurrence-free survival rates but better CSS rates. This might have been because significant numbers of the young @entity0 had Xp11 translocation @entity2 .

title: Young age as favorable prognostic factor for XXXX -specific survival in @entity2 .

answer: @entity1


abstract: BACKGROUND: Several mechanisms may associate @entity5 and related @entity1 with @entity3 . The authors studied the relationship between tooth @entity3 . METHODS: The REasons for Geographic And Racial Differences in @entity2 study is a national longitudinal study of more than 30,000 African American and white adults 45 years or older. Data for @entity5 , cognitive function and potential confounding variables were available for 9,853 @entity0 at the time of analysis. The authors used incremental linear regression modeling to investigate the cross-sectional association between self-reported tooth @entity3 . RESULTS: In unadjusted analysis (mean learning followed by recall; a level of significance of .05), the loss of six to 16 teeth and the loss of more than 16 teeth were associated with poorer cognitive function compared with the loss of no teeth. Attenuated associations persisted after the authors adjusted for demographic and systemic risk factors. The full model, which was adjusted for socioeconomic status (SES), revealed no association between tooth @entity3 . CONCLUSION: @entity5 may be associated with cognitive function; however, this association is mediated by age and SES. CLINICAL IMPLICATIONS: @entity5 due to @entity4 may be a marker for low SES, and the interplay of these factors with advanced age may confer risk of having poorer cognitive function. Further studies are needed to clarify these associations.

title: The association between self-reported tooth @entity3 in the REasons for Geographic And Racial Differences in XXXX study: an assessment of potential pathways.

answer: @entity2


abstract: BACKGROUND: Several mechanisms may associate @entity5 and related @entity1 with @entity3 . The authors studied the relationship between tooth @entity3 . METHODS: The REasons for Geographic And Racial Differences in @entity2 study is a national longitudinal study of more than 30,000 African American and white adults 45 years or older. Data for @entity5 , cognitive function and potential confounding variables were available for 9,853 @entity0 at the time of analysis. The authors used incremental linear regression modeling to investigate the cross-sectional association between self-reported tooth @entity3 . RESULTS: In unadjusted analysis (mean learning followed by recall; a level of significance of .05), the loss of six to 16 teeth and the loss of more than 16 teeth were associated with poorer cognitive function compared with the loss of no teeth. Attenuated associations persisted after the authors adjusted for demographic and systemic risk factors. The full model, which was adjusted for socioeconomic status (SES), revealed no association between tooth @entity3 . CONCLUSION: @entity5 may be associated with cognitive function; however, this association is mediated by age and SES. CLINICAL IMPLICATIONS: @entity5 due to @entity4 may be a marker for low SES, and the interplay of these factors with advanced age may confer risk of having poorer cognitive function. Further studies are needed to clarify these associations.

title: The association between self-reported tooth XXXX in the REasons for Geographic And Racial Differences in @entity2 study: an assessment of potential pathways.

answer: @entity3


abstract: OBJECTIVE: To investigate the larvicidal activity, inhibition effect on development, histopathological alteration and morphological aberration induced by the extracts derived from seaweeds Bryopsis pennata (B.  pennata), Sargassum binderi (S.  binderi) and Padina australis in @entity4 (Ae. aegypti) larvae and to characterize the phytochemical components of the three seaweeds. METHODS: Larvicidal activity of the seaweeds towards the larvae of Ae. aegypti was determined according to WHO. The inhibition effect of seaweeds was assessed by determining the mortality, adult emergence rate, larval and pupa duration of the treated larvae. Histopathological effect on midgut epithelium of larvae and morphological aberration induced by the @entity1 extracts were examined. Phytochemical analysis was done to determine the presence of alkaloids, @entity3 , @entity0 and @entity5 in the seaweeds. RESULTS: Chloroform partition of B.  pennata extract exhibited the strongest larvicidal activity (LC50  =  82.55   g/mL), followed by @entity1 extract of B.  pennata (LC50  =  160.07   g/mL) and @entity2 partition of S.  binderi extract (LC50  =  192.43   g/mL). The @entity1 extract of S.  binderi exhibited the strongest effect on prolongation of larval period (1.5-fold longer as compared to control) and  resulted in strongest inhibition effect in adult emergence (98.67%). The histopathological study showed that larvae treated with seaweed extracts had cytopathological alteration of the midgut epithelium. The morphological observation revealed that the anal papillae and terminal spiracles of larvae were the common sites of aberrations. CONCLUSIONS: The study provided information on various effects of seaweed extracts on Ae. aegypti. Further investigation on identifying the active compounds and their mechanisms of action is recommended.

title: Larvicidal activity, inhibition effect on development, histopathological alteration and morphological aberration induced by seaweed extracts in XXXX (Diptera: Culicidae).

answer: @entity4


abstract: OBJECTIVES: This study was designed to investigate the value of 3-D optical coherence tomography (3-D OCT) combined with fundus photochromy in the diagnosis of @entity1 (CSCR). SUBJECTS AND METHODS: 3-D OCT and fundus photochromy were performed on 30 @entity0 (36 eyes) with acute CSCR. @entity2 angiography (FA) was also performed to confirm the diagnosis and to obtain the @entity2 leakage sites. RESULTS: 22 eyes presented @entity4 determined by 3-D OCT (28 leakage spots), 1 eye showed @entity3 ( @entity3 ) detachment (2 leakage spots), and 13 eyes showed both @entity3 (17 leakage spots). 3-D OCT showed significant changes in the @entity3 in 36 of 47 leakage spots (76.6%). Fundus photochromy showed white-gray changes in 22 of the 47 leakage spots (59.6%). 47 leakage spots were identified by FA in 36 eyes. The combination of 3-D OCT and fundus photochromy identified 42 of the 47 leakage spots (89.4%) spotted by FA. CONCLUSION: A combination of 3-D OCT and fundus photochromy offered a high identification rate of the leakage spots. The combination of the two noninvasive techniques may be used as an alternative diagnostic or evaluation tool for acute CSCR.

title: Value of three-dimensional optical coherence tomography and fundus photochromy in correlating the @entity2 leaking sites of XXXX .

answer: @entity1


abstract: OBJECTIVES: This study was designed to investigate the value of 3-D optical coherence tomography (3-D OCT) combined with fundus photochromy in the diagnosis of @entity1 (CSCR). SUBJECTS AND METHODS: 3-D OCT and fundus photochromy were performed on 30 @entity0 (36 eyes) with acute CSCR. @entity2 angiography (FA) was also performed to confirm the diagnosis and to obtain the @entity2 leakage sites. RESULTS: 22 eyes presented @entity4 determined by 3-D OCT (28 leakage spots), 1 eye showed @entity3 ( @entity3 ) detachment (2 leakage spots), and 13 eyes showed both @entity3 (17 leakage spots). 3-D OCT showed significant changes in the @entity3 in 36 of 47 leakage spots (76.6%). Fundus photochromy showed white-gray changes in 22 of the 47 leakage spots (59.6%). 47 leakage spots were identified by FA in 36 eyes. The combination of 3-D OCT and fundus photochromy identified 42 of the 47 leakage spots (89.4%) spotted by FA. CONCLUSION: A combination of 3-D OCT and fundus photochromy offered a high identification rate of the leakage spots. The combination of the two noninvasive techniques may be used as an alternative diagnostic or evaluation tool for acute CSCR.

title: Value of three-dimensional optical coherence tomography and fundus photochromy in correlating the XXXX leaking sites of @entity1 .

answer: @entity2


abstract: UNASSIGNED: The purpose of this investigation was to study the viral aetiology of @entity2 ( @entity2 ) and acute @entity3 (ARTI) among @entity0 requiring intensive care unit admission. A cross-sectional retrospective study was carried out in Sicily over a 4-year period. A total of 233 respiratory samples of @entity0 with @entity2 /ARTI admitted to intensive care units were molecularly analyzed for the detection of a comprehensive panel of aetiologic agents of viral @entity3 . About 45% of @entity0 was positive for at least one pathogen. Single aetiology occurred in 75.2% of infected @entity0 , while polymicrobial infection was found in 24.8% of positive subjects. Influenza was the most common aetiologic agent (55.7%), especially among adults. Most of @entity0 with multiple aetiology (76.9%) were adults and elderly. Mortality rates among @entity0 with negative or positive aetiology did not significantly differ (52.4% and 47.6%, respectively). Highly transmissible respiratory pathogens are frequently detected among @entity0 with @entity2 /ARTI admitted in intensive care units, showing the occurrence of concurrent @entity1 by different viruses. The knowledge of the circulation of several types of microorganisms is of crucial importance in terms of appropriateness of therapies, but also for the implication in prevention strategies and hospital epidemiology.

title: Burden and viral aetiology of @entity2 and XXXX in intensive care units.

answer: @entity3


abstract: UNASSIGNED: The purpose of this investigation was to study the viral aetiology of @entity2 ( @entity2 ) and acute @entity3 (ARTI) among @entity0 requiring intensive care unit admission. A cross-sectional retrospective study was carried out in Sicily over a 4-year period. A total of 233 respiratory samples of @entity0 with @entity2 /ARTI admitted to intensive care units were molecularly analyzed for the detection of a comprehensive panel of aetiologic agents of viral @entity3 . About 45% of @entity0 was positive for at least one pathogen. Single aetiology occurred in 75.2% of infected @entity0 , while polymicrobial infection was found in 24.8% of positive subjects. Influenza was the most common aetiologic agent (55.7%), especially among adults. Most of @entity0 with multiple aetiology (76.9%) were adults and elderly. Mortality rates among @entity0 with negative or positive aetiology did not significantly differ (52.4% and 47.6%, respectively). Highly transmissible respiratory pathogens are frequently detected among @entity0 with @entity2 /ARTI admitted in intensive care units, showing the occurrence of concurrent @entity1 by different viruses. The knowledge of the circulation of several types of microorganisms is of crucial importance in terms of appropriateness of therapies, but also for the implication in prevention strategies and hospital epidemiology.

title: Burden and viral aetiology of XXXX and @entity3 in intensive care units.

answer: @entity2


abstract: This study investigated the role of parental motivation (importance, confidence and readiness) for predicting dropout and outcome from family-based behavioral treatment for @entity1 . Parent and @entity0 demographics, adherence to treatment, and @entity3 parameters were also explored as potential predictors. Eighty-four @entity1 @entity0 (BMI-standard deviation scores ( @entity2 ) >2.14) and a participating parent with each @entity0 started treatment consisting of 12 weeks of group and individual treatment sessions (24 sessions total) delivered over a period of 18 weeks. Sixty-one families (73%) completed treatment and attended follow-up at 1 year after treatment. @entity0 session attendance and completion of self-monitoring records served as measures of adherence. In regression analyses, parent reports (pretreatment) of confidence for doing well in treatment was the strongest predictor of treatment completion (P = 0.003) as well as early treatment response ( @entity3 at week 5) (P = 0.003). This variable remained a significant predictor of @entity0 @entity3 at post-treatment (P = 0.014), but was not associated with @entity0 outcome at 1-year follow-up (P > 0.05). The only significant predictor of @entity0 @entity3 at that point was @entity0 baseline weight (P = 0.001). However, pretreatment parent ratings of importance of and readiness for treatment did not predict dropout or @entity3 at any point. The results underscore the importance of addressing parental motivation, specifically parental confidence for changing lifestyle related behaviors, early in the treatment process. Doing so may reduce treatment dropout and enhance treatment outcome.

title: The role of parental motivation in family-based treatment for XXXX .

answer: @entity1


abstract: INTRODUCTION: During 2008-2012, a total of 466 ticks Ixodes ricinus removed from @entity0 were collected and tested for the presence of @entity1 sensu lato (Bbsl). Ticks were collected in all districts of the South Moravian region of the Czech Republic (CZ). OBJECTIVE: The aim of this study was to determine the infestation of Bbsl in ticks Ixodes ricinus and the identification of genospecies of Bbsl group by DNA sequencing. MATERIAL AND METHODS: DNA isolation from homogenates was performed by UltraClean BloodSpin DNA kit (MoBio) and by automated instrument Prepito (Perkin-Elmer). Detection of spirochetes was carried out by RealTime PCR kit EliGene @entity2 (Elisabeth Pharmacon). Finally, all the positive samples were sequenced on an ABI 3130 Genetic Analyzer (Life Technologies) and identified in the BLAST (NCBI) database. RESULTS: A total positivity of the samples was 26%. For the first time in the Czech Republic, 5 of the isolated strains were genotyped as @entity6 (7.1%). Other representatives of Bbsl were also observed: @entity4 (70.0%), @entity5 (10.0%), @entity3 (8.6%), and @entity1 s. s. (4.3%). CONCLUSION: A general view of the spreading of Bbsl in the South Moravian region was demonstrated. The most interesting result of the study is the finding of @entity6 for the first time in this region.

title: Identification of XXXX genospecies isolated from Ixodes ricinus ticks in the South Moravian region of the Czech Republic.

answer: @entity1


abstract: @entity2 makes up 25-30% of all cases of @entity1 of the female genital tract. It has the highest mortality rate of any condition in oncological gynaecology. Early diagnosis is associated with a favourable 5-year survival prognosis. Many solid @entity1 have been detected with concomitant @entity4 . The @entity1 cell-induced @entity5 is a result of a direct integration of @entity1 cells with blood platelets. The aim of the present paper is an evaluation of platelet count as a prognostic parameter for @entity2 . Between 2000 - 2005, 349 @entity0 with @entity2 (aged 12 - 88-years-old) underwent primary surgical treatment at a clinic. Ninety-seven @entity0 with @entity2 underwent chemotherapy in the Oncology Centre. The control group comprised 252 @entity0 diagnosed with a histopathological lesion of mild intensity, whereas the @entity1 group constituted 97 @entity0 with a histopathologically-diagnosed malignant @entity1 . Thrombocytopaenia was assumed with a platelet count below @entity6 and thrombocythaemia at 350G/L and higher. @entity4 often coincides with @entity3 and the cytoreduction decreases platelet count. There is a positive correlation between platelet count and @entity1 grading. @entity4 was more frequently found in high grade @entity1 . There is also a positive correlation between platelet count and @entity1 stage according the International Federation of Gynaecology and Obstetrics (FIGO). @entity4 was more frequently found in stage III and IV @entity1 . @entity0 with co-occurring @entity4 were found to have shorter survival periods and shorter time free from disease. This seems to give grounds for measuring platelet count before the primary surgical intervention, and suggests that the platelet count should be included in the panel of prognostic factors for @entity0 with @entity2 .

title: The prognostic significance of XXXX in @entity2 .

answer: @entity4


abstract: @entity2 makes up 25-30% of all cases of @entity1 of the female genital tract. It has the highest mortality rate of any condition in oncological gynaecology. Early diagnosis is associated with a favourable 5-year survival prognosis. Many solid @entity1 have been detected with concomitant @entity4 . The @entity1 cell-induced @entity5 is a result of a direct integration of @entity1 cells with blood platelets. The aim of the present paper is an evaluation of platelet count as a prognostic parameter for @entity2 . Between 2000 - 2005, 349 @entity0 with @entity2 (aged 12 - 88-years-old) underwent primary surgical treatment at a clinic. Ninety-seven @entity0 with @entity2 underwent chemotherapy in the Oncology Centre. The control group comprised 252 @entity0 diagnosed with a histopathological lesion of mild intensity, whereas the @entity1 group constituted 97 @entity0 with a histopathologically-diagnosed malignant @entity1 . Thrombocytopaenia was assumed with a platelet count below @entity6 and thrombocythaemia at 350G/L and higher. @entity4 often coincides with @entity3 and the cytoreduction decreases platelet count. There is a positive correlation between platelet count and @entity1 grading. @entity4 was more frequently found in high grade @entity1 . There is also a positive correlation between platelet count and @entity1 stage according the International Federation of Gynaecology and Obstetrics (FIGO). @entity4 was more frequently found in stage III and IV @entity1 . @entity0 with co-occurring @entity4 were found to have shorter survival periods and shorter time free from disease. This seems to give grounds for measuring platelet count before the primary surgical intervention, and suggests that the platelet count should be included in the panel of prognostic factors for @entity0 with @entity2 .

title: The prognostic significance of @entity4 in XXXX .

answer: @entity2


abstract: Fumonisins are mycotoxins produced by @entity3 (= @entity3 ) and other Fusarium species. They are found in @entity2 and @entity2 -based foods. Cooking decreases @entity7 concentrations in food products under some conditions; however, little is known about how cooking effects biological activity. Baked cornbread, pan-fried corncakes, and deep-fried fritters were made from cornmeal that was spiked with 5% w/w @entity3 culture material (CM). The cooked materials and the uncooked CM-spiked cornmeal were fed to male @entity0 (n = 5/group) for 2 weeks at high (20% w/w spiked cornmeal equivalents) or low (2% w/w spiked cornmeal equivalents) doses. A control group was fed a diet containing 20% w/w unspiked cornmeal. Toxic response to the uncooked CM-spiked cornmeal and the cooked products included decreased body @entity1 (high-dose only), decreased kidney weight, and microscopic kidney and liver lesions of the type caused by fumonisins. @entity7 concentration, as determined by HPLC analysis, in the 20% w/w pan-fried corncake diet [92.2 ppm of @entity4 (FB(1))] was slightly, but not statistically significantly, lower than those of the 20% w/w baked cornbread (132.2 ppm of @entity5 ), deep-fried fritter (120.2 ppm of @entity5 ) and CM-spiked cornmeal (130.5 of ppm FB(1)) diets. Therefore, baking and frying had no significant effect on the biological activity or concentration of @entity6 in these @entity2 -based products, and the results provided no evidence for the formation of novel toxins or "hidden" fumonisins during cooking.

title: Effect of baking and frying on the in vivo toxicity to XXXX of cornmeal containing fumonisins.

answer: @entity0


abstract: BACKGROUND: @entity4 ( @entity4 ) is a malignancy that occurs in white blood cells. The overall cure rate in @entity0 is 85%, whereas it is only 40% in adults. Kefir is an important probiotic that contains many bioactive ingredients, which give it unique health benefits. It has been shown to control several cellular types of @entity1 . PURPOSE: The present study investigates the effect of a cell-free fraction of kefir on CEM and Jurkat cells, which are @entity0 T-lymphotropic virus type I (HTLV- @entity8 )-negative malignant T-lymphocytes. METHODS: Cells were incubated with different kefir concentrations. The @entity2 of the compound was evaluated by determining the percentage viability of cells. The effect of all the noncytotoxic concentrations of kefir on the proliferation of CEM and Jurkat cells was then assessed. The levels of @entity3 ( @entity9 ), @entity7 ( @entity7 ), @entity5 ( @entity5 ), and @entity6 mRNA upon kefir treatment were then analyzed using reverse transcriptase polymerase chain reaction (RT-PCR). Finally, the growth inhibitory effects of kefir on cell-cycle progression/apoptosis were assessed by Cell Death Detection (ELISA) and flow cytometry. RESULTS: The maximum @entity2 recorded after 48-hours treatment with 80  g/ L kefir was only 42% and 39% in CEM and Jurkat cells, respectively. The percent reduction in proliferation was very significant, and was dose-, and time-dependent. In both cell lines, kefir exhibited its antiproliferative effect by downregulating @entity9 and upregulating @entity7 mRNA expression. Upon kefir treatment, a marked increase in cell-cycle distribution was noted in the preG(1) phase of CEM and Jurkat cells, indicating the proapoptotic effect of kefir, which was further confirmed by Cell Death Detection ELISA. However, kefir did not affect the mRNA expression of metalloproteinases needed for the invasion of leukemic cell lines. CONCLUSION: In conclusion, kefir is effective in inhibiting proliferation and inducing apoptosis of @entity8 -negative malignant T-lymphocytes. Therefore, further in vivo investigation is highly recommended.

title: Kefir induces cell-cycle arrest and apoptosis in XXXX -negative malignant T-lymphocytes.

answer: @entity8


abstract: We performed a MEDLINE and EMBASE search to identify all studies published in the last decade in the English language literature on the use of progestogens for the treatment of @entity1 . Our aim was to clarify the biological rationale for treatment and define the drugs that can be used with their doses, routes of administration, efficacy and tolerability. Progestogens may prevent implantation and growth of regurgitated endometrium inhibiting expression of matrix metalloproteinases and angiogenesis, and they have several anti-inflammatory in-vitro and in-vivo effects that may reduce the inflammatory state generated by the metabolic activity of the ectopic endometrium, and the consequent immune response. Oral contraceptives increase the abnormally low apoptotic activity of the endometrium of @entity0 with @entity1 . Moreover, anovulation, decidualization, @entity4 and the establishment of a steady @entity3 -progestogen milieu contribute to disease quiescence. Progestogens are effective in the control of @entity2 symptoms in approximately three out of four @entity0 with @entity1 . Their effect does not seem to be inferior to that of other drugs used for the disease. Different compounds can be administered by the oral, intramuscular, subcutaneous, intravaginal or intrauterine route, each with specific advantages or disadvantages. Medical treatment plays a role in the therapeutic strategy when administered over a prolonged period of time. Given their good tolerability, minor metabolic effects and low cost, progestogens must therefore be considered drugs of choice and are currently the only safe and economic alternative to surgery. However, their contraceptive effectiveness limits their use to @entity0 who do not wish to have @entity0 in the short term.

title: Progestogens for XXXX : forward to the past.

answer: @entity1


abstract: OBJECTIVE: To evaluate the effects of a high-protein diet versus dietary supplementation with @entity4 ( @entity7 ) on @entity3 crystal formation in the urine of clinically normal @entity0 by measuring the urine concentration of @entity6 ( @entity5 )-insoluble sediment, urine pH, @entity3 activity product (SAP), number of @entity3 crystals in urine, and urine volume. ANIMALS: 23 healthy adult @entity0 . PROCEDURE: Urine was fractionated by centrifugation with subsequent extraction of the sediment with 1 N @entity5 (study 1). Diets containing either 29% crude protein or 55% crude protein were fed to @entity0 in a crossover trial of 3 weeks/period (study 2). Diets supplemented with either @entity2 ( @entity1 ) or @entity7 were fed, by use of a 3 x 3 Latin-square design with 3 wk/period (study 3). In studies 2 and 3, urine samples were collected for the last 7 days of each period. RESULTS: The @entity5 -insoluble sediment contained Tamm-Horsfall glycoprotein (THP; study 1). The high-protein diet (study 2) and dietary supplementation with @entity7 (study 3) resulted in a decrease in urine pH, SAP, and the number of @entity3 crystals in urine. However, the high-protein diet decreased urine concentrations of @entity5 -insoluble sediment containing THP (study 2), in contrast to the @entity7 supplementation that increased urine volume without a significant effect on the urine concentration of the @entity5 -insoluble sediment (study 3). CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that compared with dietary supplementation with @entity7 , the high-protein diet is preferable as a urine acidifier for the prevention of @entity3 crystal formation in clinically normal @entity0 .

title: Effects of a high-protein diet versus dietary supplementation with XXXX on @entity3 crystal formation in urine of clinically normal @entity0 .

answer: @entity4


abstract: OBJECTIVE: To evaluate the effects of a high-protein diet versus dietary supplementation with @entity4 ( @entity7 ) on @entity3 crystal formation in the urine of clinically normal @entity0 by measuring the urine concentration of @entity6 ( @entity5 )-insoluble sediment, urine pH, @entity3 activity product (SAP), number of @entity3 crystals in urine, and urine volume. ANIMALS: 23 healthy adult @entity0 . PROCEDURE: Urine was fractionated by centrifugation with subsequent extraction of the sediment with 1 N @entity5 (study 1). Diets containing either 29% crude protein or 55% crude protein were fed to @entity0 in a crossover trial of 3 weeks/period (study 2). Diets supplemented with either @entity2 ( @entity1 ) or @entity7 were fed, by use of a 3 x 3 Latin-square design with 3 wk/period (study 3). In studies 2 and 3, urine samples were collected for the last 7 days of each period. RESULTS: The @entity5 -insoluble sediment contained Tamm-Horsfall glycoprotein (THP; study 1). The high-protein diet (study 2) and dietary supplementation with @entity7 (study 3) resulted in a decrease in urine pH, SAP, and the number of @entity3 crystals in urine. However, the high-protein diet decreased urine concentrations of @entity5 -insoluble sediment containing THP (study 2), in contrast to the @entity7 supplementation that increased urine volume without a significant effect on the urine concentration of the @entity5 -insoluble sediment (study 3). CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that compared with dietary supplementation with @entity7 , the high-protein diet is preferable as a urine acidifier for the prevention of @entity3 crystal formation in clinically normal @entity0 .

title: Effects of a high-protein diet versus dietary supplementation with @entity4 on XXXX crystal formation in urine of clinically normal @entity0 .

answer: @entity3


abstract: OBJECTIVE: To evaluate the effects of a high-protein diet versus dietary supplementation with @entity4 ( @entity7 ) on @entity3 crystal formation in the urine of clinically normal @entity0 by measuring the urine concentration of @entity6 ( @entity5 )-insoluble sediment, urine pH, @entity3 activity product (SAP), number of @entity3 crystals in urine, and urine volume. ANIMALS: 23 healthy adult @entity0 . PROCEDURE: Urine was fractionated by centrifugation with subsequent extraction of the sediment with 1 N @entity5 (study 1). Diets containing either 29% crude protein or 55% crude protein were fed to @entity0 in a crossover trial of 3 weeks/period (study 2). Diets supplemented with either @entity2 ( @entity1 ) or @entity7 were fed, by use of a 3 x 3 Latin-square design with 3 wk/period (study 3). In studies 2 and 3, urine samples were collected for the last 7 days of each period. RESULTS: The @entity5 -insoluble sediment contained Tamm-Horsfall glycoprotein (THP; study 1). The high-protein diet (study 2) and dietary supplementation with @entity7 (study 3) resulted in a decrease in urine pH, SAP, and the number of @entity3 crystals in urine. However, the high-protein diet decreased urine concentrations of @entity5 -insoluble sediment containing THP (study 2), in contrast to the @entity7 supplementation that increased urine volume without a significant effect on the urine concentration of the @entity5 -insoluble sediment (study 3). CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that compared with dietary supplementation with @entity7 , the high-protein diet is preferable as a urine acidifier for the prevention of @entity3 crystal formation in clinically normal @entity0 .

title: Effects of a high-protein diet versus dietary supplementation with @entity4 on @entity3 crystal formation in urine of clinically normal XXXX .

answer: @entity0


abstract: Fructans are fermentable carbohydrates and include short-chain fructooligosaccharides (scFOS), inulin, and hydrolyzed inulin ( @entity6 , OF). Two studies with @entity1 were designed to examine the effects of low concentrations of fructans on nutrient digestibilities, fecal microbial populations, and endproducts of protein fermentation, and fecal characteristics. In Exp. 1, 11 adult male beagles were fed @entity4 -based, kibbled diets supplemented with or without OF to provide 1.9 +/- 0.6 g/d. Dietary inclusion of OF decreased (P < 0.05) nutrient digestibilities, but did not affect fecal characteristics. Increasing OF concentration tended (P < 0.06) to linearly decrease fecal @entity3 concentrations, but not those of @entity10 ( @entity10 ), @entity5 , @entity0 , or @entity7 . Fecal concentrations of total @entity8 (SCFA) and butyrate tended to be higher in OF-supplemented @entity1 (P < 0.10), as was the ratio of bifidobacteria to total anaerobes (P = 0.15). In Exp. 2, ileally cannulated adult female hounds were fed a meat-based kibbled diet and were assigned to four scFOS treatments (0, 1, 2, or 3 g/d) in a 4 x 4 Latin square design. Ileal nutrient digestibilities tended to increase (P < 0.15) with increasing concentrations of scFOS. On a DMI basis, fecal output tended to decrease linearly (P < 0.10) in response to increasing scFOS supplementation, whereas fecal score tended to exhibit a quadratic response (P = 0.12). In general, fecal concentrations of SCFA, @entity10 , @entity3 , @entity7 , and @entity9 were not altered by supplemental scFOS. Supplementation of scFOS increased fecal concentrations of total aerobes (P < 0.05) and decreased concentrations of @entity2 (P < 0.05). From these data, it seems that low levels of supplemental fructans have divergent effects on nutrient digestibility and fermentative endproducts, but do not adversely affect nutrient digestibility or fecal characteristics and may improve colonic microbial ecology in @entity1 .

title: Nutrient digestibilities, microbial populations, and protein catabolites as affected by fructan supplementation of XXXX diets.

answer: @entity1


abstract: The aim of this study was to examine maximal voluntary knee-extensor contraction force (MVC force), sarcoplasmic reticulum (SR) function and muscle glycogen levels in the days after a high-level soccer game when players ingested an optimised diet. Seven high-level male soccer players had a vastus lateralis muscle biopsy and a blood sample collected in a control situation and at 0, 24, 48 and 72 h after a competitive soccer game. MVC force, SR function, muscle glycogen, muscle soreness and plasma myoglobin were measured. MVC force sustained over 1 s was 11 and 10% lower (P < 0.05) after 0 and 24 h, respectively, compared with control. The rate of SR @entity0 uptake at 800 nM [ @entity0 ](free) was lower (P < 0.05) after 0 h (2.5  mol @entity0 g prot(-1) min(-1)) than for all other time points (24 h: 5.1  mol @entity0 g prot(-1) min(-1)). However, SR @entity0 release rate was not affected. Plasma myoglobin was sixfold higher (P < 0.05) immediately after the game, but normalised 24 h after the game. Quadriceps muscle soreness (0-10 VAS-scale) was higher (P < 0.05) after 0 h (3.6), 24 h (1.8), 48 h (1.1) and 72 h (1.4) compared with control (0.1). Muscle glycogen was 57 and 27% lower (P < 0.001) 0 and 24 h after the game compared with control (193 and 328 vs. 449 mmol kg d w(-1)). In conclusion, maximal @entity1 force and SR @entity0 uptake were impaired and muscle soreness was elevated after a high-level soccer game, with faster recovery of SR function in comparison with MVC force, soreness and muscle glycogen.

title: XXXX force, SR function and glycogen resynthesis during the first 72 h after a high-level competitive soccer game.

answer: @entity1


abstract: BACKGROUND/AIMS: Several studies have found that the frequency of @entity4 increases significantly from the age of 50 years. The goal of this study was to determine the differences in the clinical characteristics of @entity4 between @entity0 aged 50 years and older, and younger @entity0 . METHODS: The colonoscopy database of 3,304 @entity0 at the Yeungnam University Medical Center between January 2009 and December 2009 was reviewed retrospectively. In total, 679 @entity0 were divided into the younger group (n=170) and the older group (aged >= 50 years) (n=509). A matched case-control study was performed using propensity scores and 117 @entity0 selected from each group. RESULTS: Compared to the younger group, the older group had a significantly higher proportion of female @entity0 , and @entity0 with @entity3 , a smoking history, and a history of taking medications. After performing the matched case-control study, 234 @entity0 and 679 @entity5 were included in the analysis. Compared to the younger @entity0 , the older @entity0 had a significantly higher proportion of @entity2 (57.3% vs 25.6%, p<0.001), left- and right-side distribution (35.9% vs 12.0%, p<0.001), and larger @entity4 (mean 9.1 mm vs 6.3 mm, p<0.001). A left-sided distribution was less common in the older group than in the younger group (35.0% vs 51.3%, p=0.025). CONCLUSIONS: The methods used to screen for @entity1 in older @entity0 should include colonoscopy due to the shift to the right side as a common location for @entity4 in that age group.

title: A Matched Case-Control Study Using the Propensity Score on Differences in the Characteristics of @entity4 between Younger and Older Koreans: Proximal Shift in the Distribution of XXXX among Older Koreans.

answer: @entity4


abstract: BACKGROUND/AIMS: Several studies have found that the frequency of @entity4 increases significantly from the age of 50 years. The goal of this study was to determine the differences in the clinical characteristics of @entity4 between @entity0 aged 50 years and older, and younger @entity0 . METHODS: The colonoscopy database of 3,304 @entity0 at the Yeungnam University Medical Center between January 2009 and December 2009 was reviewed retrospectively. In total, 679 @entity0 were divided into the younger group (n=170) and the older group (aged >= 50 years) (n=509). A matched case-control study was performed using propensity scores and 117 @entity0 selected from each group. RESULTS: Compared to the younger group, the older group had a significantly higher proportion of female @entity0 , and @entity0 with @entity3 , a smoking history, and a history of taking medications. After performing the matched case-control study, 234 @entity0 and 679 @entity5 were included in the analysis. Compared to the younger @entity0 , the older @entity0 had a significantly higher proportion of @entity2 (57.3% vs 25.6%, p<0.001), left- and right-side distribution (35.9% vs 12.0%, p<0.001), and larger @entity4 (mean 9.1 mm vs 6.3 mm, p<0.001). A left-sided distribution was less common in the older group than in the younger group (35.0% vs 51.3%, p=0.025). CONCLUSIONS: The methods used to screen for @entity1 in older @entity0 should include colonoscopy due to the shift to the right side as a common location for @entity4 in that age group.

title: A Matched Case-Control Study Using the Propensity Score on Differences in the Characteristics of XXXX between Younger and Older Koreans: Proximal Shift in the Distribution of @entity4 among Older Koreans.

answer: @entity4


abstract: The scaphocapitate @entity4 is a rare entity of a perilunate @entity4 . The diagnosis is frequently missed at initial presentation to a physician. Usually, a CT scan is required to reveal the extent of the lesion. Operative treatment consists of open reduction and internal fixation with screws (e.g. headless compression screw) or Kirschner wires. We report on a case of a 19-year-old @entity0 who presented to our hospital 2 months after he fell on his left wrist. He complained about persistent @entity3 and a decreased range of motion after conservative treatment in a short arm cast. The diagnosis was finally made by a CT scan and the @entity0 was treated operatively using headless compression screws in both the capitate and the scaphoid. After 12 weeks, @entity4 were completely healed radiographically and the @entity0 returned to work. At follow-up 16 months after @entity2 , the @entity0 had no further complaints. Range of motion increased and no avascular @entity1 could be observed.

title: Successful delayed surgical treatment of a scaphocapitate XXXX .

answer: @entity4


abstract: The seeds of Tectona grandis Linn. are traditionally acclaimed as hair tonic in the Indian system of medicine. Studies were therefore undertaken in order to evaluate petroleum ether extract of T. grandis seeds for its effect on hair growth in albino @entity0 . The 5% and 10% extracts incorporated into simple ointment base were applied topically on shaved denuded skin of albino @entity0 . The time required for initiation of hair growth as well as completion of hair growth cycle was recorded. @entity1 2% solution was applied topically and served as positive control. The result of treatment with @entity1 2% is 49% hair in anagenic phase. Hair growth initiation time was significantly reduced to half on treatment with the extracts compared to control animals. The treatment was successful in bringing a greater number of hair follicles (64% and 51%) in anagenic phase than standard @entity1 (49%). The results of treatment with 5% and 10% petroleum ether extracts were comparable to the positive control @entity1 .

title: Effect of Tectona grandis Linn. seeds on hair growth activity of albino XXXX .

answer: @entity0


abstract: BACKGROUND: Lymph node ratio (LNR) has been reported to represent a powerful independent prognostic value in some @entity1 . The significance of LNR in @entity2 is still under debate. METHODS: A total of 505 @entity0 with @entity2 were reviewed. Using running log-rank statistics, we calculated the best cutoff values for LNRs and proposed a novel rN category: rN1, 0%  <  LNR   <=  35%; rN2, 35%  <  LNR   <=  69%; and @entity3 , LNR  >  69%. A Spearman's correlation coefficient test was used to assess the correlation between the number of retrieved nodes and the number of metastatic nodes, as well as the number of retrieved nodes and the LNRs. Univariate and two-step multivariate analyses were performed, respectively, to identify the significant prognostic clinicopathologic factors. RESULTS: The 5-year overall survival rate decreased significantly with increasing LNRs: rN(1)  =  61% survival rate, rN(2)  =  30.3% survival rate, and rN(3)  =  11.2% survival rate (P  <  0.001). Univariate and two-step multivariate analyses identified the rN category as a significant prognostic factor no matter whether the minimum number of LNs retrieved was met. There was a significant prognostic difference among different rN categories for any pN category, but no apparent prognostic difference was seen between different pN categories in any rN category. Moreover, marked heterogeneity could be seen within III(a-c) substages when survival was compared among rN(1-3) categories but not between pN(1-2) categories. CONCLUSIONS: rN categories have more potential for predicting @entity0 outcomes and are superior to the UICC/AJCC pN categories. We recommend rN categories for prognostic assessment and rN categories should be reported routinely in histopathological reports.

title: Can lymph node ratio take the place of pN categories in the UICC/AJCC TNM classification system for XXXX ?

answer: @entity2


abstract: OBJECTIVE: To explore the efficacy difference in @entity1 between auricular point sticking and the combined therapy of auricular point sticking and body acupuncture, as well as the efficacy difference among various body constitutions. METHODS: One hundred cases of @entity1 were randomized into two groups, auricular point sticking group (group A) and the combined therapy of auricular point sticking and body acupuncture group (group B), 50 cases in each one. In group A, semen vaccariae was fixed with plaster on the spleen, stomach, endocrine, small intestine, buttocks, tibia, forearm, etc. in the ear. Each point was pressed 3 times daily, for 5 mm each time. The ear-points on two sides were alternated every two days. In group B, the auricular point sticking and body acupuncture were applied. The ear points and manipulation were same as the previous. Body points were Zhongwan (CV 12), (Juanyuan (CV 4), Tiansho (ST 25), Zusanli (ST 36), Sanyinjiao ( @entity3 ), etc. Acupuncture was applied with filiform needle, once every two days. The changes in body weight and body mass index (BMI) were observed after 20 treatments. RESULTS: (1) The total effective rate was 94.0% (47/50) in group A and was 98.0% (49/50) in group B, without statistical significant difference (P > 0.05). The comparison of mean body weight and mean BMI after intervention did not show statistical significance between two groups (both P > 0.05), indicating that the simple auricular point sticking could achieve the same effect as the combined therapy. (2) There was no statistical significant difference in the total effective rate between the thin @entity0 with spleen and @entity2 constitution and those with normal constitution among 100 cases (P > 0.05). But, the remarkable effective rates were different significantly in statistics (P < 0.05). For the thin @entity0 with spleen and @entity2 constitution, after treatment, the body weight increased in big amplitude, but those with normal constitution increased in small amplitude or had no change. CONCLUSION: The efficacy of the simple auricular point sticking on @entity1 is same as the combined therapy of auricular point sticking and body acupuncture, and is much better for the cases with spleen and @entity2 constitution.

title: [Auricular point sticking and the combined therapy of auricular point sticking and body acupuncture for XXXX in 100 cases].

answer: @entity1


abstract: The morphology of the large intrapulmonary arteries (PAs) in @entity1 ( @entity1 ) has received limited attention. Dilation, pruning, abrupt tapering, and tortuosity of PAs occur, but whether different @entity0 have distinct PA phenotypes is unknown. Pulmonary arteriograms from 41 pediatric @entity0 with @entity1 were blindly reviewed by four experts who assigned each angiogram one of three designations: straight (S), tortuous (T), or ambiguous (A). Hemodynamic variables and outcomes were compared to the phenotypes. Thirty @entity0 were either T (19) or S (11); 11 were A. The phenotypes were not associated with age. Tortuous @entity0 had higher PA pressure and resistance than the S group and less likely to react to inhaled @entity2 than S @entity0 (p < 0.05). Clinical outcomes were similar for the three groups. Thus, in @entity1 @entity0 two subtypes of PA morphology can often be discerned, a reflection of variability in PA tortuosity. These morphological subtypes have differing hemodynamic characteristics. The mechanism(s) underlying these differences is unknown, but neither hydrodynamic factors nor duration of @entity1 are fully explanatory. Because PA morphology might reveal information regarding the biology of pathological remodeling, it might prove enlightening to assess the large PA phenotype in future studies of @entity1 .

title: XXXX : what the large pulmonary arteries tell us.

answer: @entity1


abstract: BACKGROUND: Retrospective study about results of treatment of @entity0 (pts) with primary ( @entity8 ) and secondary (AA) @entity10 is given. 31 pts with systemic forms of @entity10 have been treated and followed-up in our department since 1993. METHODS AND RESULTS: 6 @entity0 and 11 @entity0 were in the @entity8 group with the mean age of 59 years. @entity8 was diagnosed in 9 pts, @entity12 ( @entity12 ) was found in 8 pts. The kidneys were affected in all pts, heart in 59% of pts, @entity5 and skin in 26% of pts and @entity3 was detected only in 1 pt. Progression of @entity2 with decrease of glomerular filtration rate (GFR) was detected in the @entity8 group at the end of follow-up period compared with the initial level (p < 0.05) despite the intensive treatment. The difference did not reach statistical significance in other investigated parameters. Median of survival was 13 months from the assessment of diagnosis. Partial remission of @entity10 was achieved in 9 pts, stable disease was in 5 pts and in 3 pts the disease progressed. 4 @entity0 and 10 @entity0 were in the AA group with mean age of 58 years. Underlying disease was @entity4 in 7 pts, @entity9 in 2 pts, @entity11 in 1 pt, @entity1 in 2 pts, @entity13 in 1 pt and chronic @entity7 in 1 pt. The kidneys were affected in all pts, bowels and heart in 36% of pts. GFR (p < 0.05) and plasma @entity6 (p < 0.01) significantly decreased at the end of follow-up period compared with initial levels. Median of survival was 30 months. Partial remission was achieved in 2 pts, stable disease was in 3 pts and progression was detected in 9 pts despite the use of various treatment regimens. CONCLUSIONS: Both forms of @entity8 represent severe disease with limited response to treatment. The use of new drugs is promising and could lead to better response to treatment.

title: [Is the current treatment of primary and secondary XXXX effective?].

answer: @entity10


abstract: BACKGROUND: @entity2 depletion of the striatum is one of the hallmarks of @entity1 . The loss of @entity2 upregulates @entity4 expression in the striatal projection neurons and causes other changes in the activity of the basal ganglia circuit. METHODS: To normalize the @entity4 expression in the striatum after @entity2 depletion, we developed several lentiviral vectors that express RNA interference (RNAi) directed against @entity4 mitochondrial RNA. The vectors were injected into the striatum of hemiparkinsonian @entity0 and the level of @entity4 protein as well as a marker of neuronal activity, @entity3 , was analyzed using western blots. RESULTS: Unilateral lesions of the @entity2 neurons in substantia nigra resulted in an increased level of @entity4 protein in the ipsilateral striatum. Furthermore, we detected significantly higher levels of @entity3 , after @entity2 depletion in the striatum. Using a lentiviral vectors with a synthetic miRNA scaffold to deliver RNAi, we were able to normalize the @entity4 protein levels in the @entity1 @entity0 striatum. In addition, we were able to normalize the increased neural activity, which resulted from the loss of @entity2 as measured by the marker @entity3 . CONCLUSIONS: We conclude that RNAi directed against @entity4 may be a valid approach to correct the dysregulation of the basal ganglia circuit in a @entity0 model of @entity1 . The possibility to correct for a loss of @entity2 using nondopamimetic tools is interesting because it may be more directed towards the casual mechanisms of the motor symptoms.

title: Knockdown of XXXX protein levels normalizes neuronal activity in a @entity0 model of @entity1 .

answer: @entity4