abstract: Dengue is the most common @entity1 of @entity0 and is a public health burden in more than 100 countries. @entity5 mosquitoes stably infected with strains of the intracellular bacterium Wolbachia are resistant to @entity2 and are being tested in field trials. To mimic field conditions, we experimentally assessed the vector competence of A. aegypti carrying the Wolbachia strains wMel and wMelPop after challenge with viremic blood from dengue @entity0 . We found that wMelPop conferred strong resistance to DENV @entity1 of mosquito abdomen tissue and largely prevented disseminated @entity1 . wMel conferred less resistance to @entity1 of mosquito abdomen tissue, but it did reduce the prevalence of mosquitoes with infectious saliva. A mathematical model of DENV transmission incorporating the dynamics of @entity4 in @entity0 and mosquitoes was fitted to the data collected. Model predictions suggested that wMel would reduce the basic reproduction number, R0, of DENV transmission by 66 to 75%. Our results suggest that establishment of wMelPop-infected A. aegypti at a high frequency in a @entity3 would result in the complete abatement of DENV transmission. Establishment of wMel-infected A. aegypti is also predicted to have a substantial effect on transmission that would be sufficient to eliminate dengue in low or moderate transmission settings but may be insufficient to achieve complete control in settings where R0 is high. These findings develop a framework for selecting Wolbachia strains for field releases and for calculating their likely impact.

title: Modeling the impact on virus transmission of Wolbachia-mediated blocking of XXXX of @entity5 .

answer: @entity2


abstract: BACKGROUND/OBJECTIVES: To describe how @entity0 experiencing @entity1 define quality of life and how this may be supported. DESIGN: Qualitative descriptive component of mixed methods cross-sectional study. SETTING: Western Canadian community (4-h weekly care minimum), supportive housing (24-h support/supervision), personal care homes (24-h nursing). @entity0 : One hundred and thirty-six @entity0 aged 65+ experiencing @entity1 . MEASUREMENTS: Semi-structured interview questions. Rating of meeting life's goals. RESULTS: @entity0 characterised quality of life as: freedom, independence, having basic needs met, physical health, engagement in meaningful activities and tranquility. A need for self-determination/choice was evidenced across all domains. Increased access to skilled nursing care, support for meaningful engagement with family and meeting life's goals were endorsed as adding most to quality of life; 43% reported meeting all life' @entity2 goals. CONCLUSION: @entity0 experiencing @entity1 may have better quality of life when choice/self-determination is supported. Enhancements in care environment, independence, engagement and meeting of life's goals merit urgent attention.

title: Subjective quality of life of those 65 years and older experiencing XXXX .

answer: @entity1


abstract: UNASSIGNED: The recent recognition that antibody-mediated rejection (ABMR) is the major cause of kidney transplant loss creates strong interest in its pathogenesis. We used microarray analysis of kidney transplant biopsies to identify the changes in pure ABMR. We found that the ABMR transcript changes in the initial Discovery Set were strongly conserved in a subsequent Validation Set. In the Combined Set of 703 biopsies, 2603 transcripts were significantly changed (FDR   <   0.05) in ABMR versus all other biopsies. In cultured cells, the transcripts strongly associated with ABMR were expressed in endothelial cells, e.g. cadherins @entity5 and @entity8 ; @entity3 -treated endothelial cells, e.g. phospholipase @entity11 and chemokine @entity2 ; or NK cells, e.g. @entity1 molecules granulysin ( @entity10 ) and @entity12 . Other ABMR transcripts were expressed in normal kidney but not cell lines, either increased e.g. Duffy @entity4 ( @entity9 ) or decreased e.g. sclerostin ( @entity7 ). Pathway analysis of ABMR transcripts identified angiogenesis, with roles for angiopoietin and vascular endothelial growth factors; leukocyte-endothelial interactions; and NK signaling, including evidence for @entity6 a Fc receptor signaling elements shared with T cells. These data support a model of ABMR involving @entity0 in the microcirculation induced by cognate recognition involving antibody and @entity6 , triggering @entity3 release and antibody-dependent NK cell-mediated @entity1 .

title: The Molecular Landscape of Antibody-Mediated Kidney Transplant Rejection: Evidence for NK Involvement Through XXXX a Fc Receptors.

answer: @entity6


abstract: BACKGROUND: Elevated blood pressure (BP) during early life years is associated with future risk of @entity2 and @entity1 and mortality. This study aimed to determine the prevalence and lifestyle factors associated with @entity3 (systolic BP (SBP) 120-139mm Hg and/or diastolic BP (DBP) 80-89mm Hg) or @entity2 (SBP >=  140mm Hg and/or DBP >=  90mm Hg or on antihypertensive medications) among young adults at a Singapore university. METHODS: A cross-sectional survey of 501 university-going young adults aged 18-40 years in Singapore was conducted using convenience sampling. Data on BP, body mass index (BMI), and lifestyle factors (meals eaten away from home/week, physical activity) was collected, and their association with @entity3 or @entity2 was determined. RESULTS: @entity3 was found in 27.4% (95% confidence interval (95% CI) = 24-32) of the population: 49% (44-58) in @entity0 and 9% (6-13) in @entity0 (P < 0.001). 2.2% (1.2-3.9) had @entity2 . In a multivariable model, those with @entity3 or @entity2 tended to eat more meals away from home per week (per meal/week odds ratio (OR) = 1.05, 95% CI = 1.01-1.09), have higher BMI (per kg/m(2) OR = 1.15, 95% CI = 1.02-1.30), and low physical activity (low vs. moderate/high activity OR = 2.14, 95% CI = 1.20-3.82). Other associates were male gender (OR = 7.01, 95% CI = 3.97-12.4) and older age (per year OR = 1.06, 95% CI = 1.01-1.11). CONCLUSION: @entity3 may be common among university-going young adults in Singapore and is associated with potentially preventable lifestyle factors. Our findings call for large-scale population-based studies, including lifestyle modification trials for prevention of @entity2 among young adults in Singapore.

title: The Association of XXXX With Meals Eaten Away From Home in Young Adults in Singapore.

answer: @entity3


abstract: UNASSIGNED: @entity3 ( @entity3 ) are highly malignant and @entity2 lack of effective therapeutic drugs. @entity11 (PL), a natural product isolated from longer pepper plants, is recently identified as a potent cytotoxic compound highly selective to @entity0 cells. Here, we reported that PL specifically suppressed @entity3 cell migration/invasion via endoplasmic reticulum (ER)-MAPKs- @entity6 signaling pathway. PL selectively killed @entity3 cells but not normal hepatocytes with an IC50 of 10-20   M while PL at much lower concentrations only suppressed @entity3 cell migration/invasion. PL selectively elevated reactive @entity1 species (ROS) in @entity3 cells, which activated or up-regulated downstream @entity10 / @entity9 / @entity5 , @entity4 / @entity8 / @entity7 and @entity6 subsequently. Administration of antioxidants completely abolished PL's effects on cell death and migration/invasion. However, pharmacological inhibition of ER stress-responses or MAPKs signaling pathways with corresponding specific inhibitors only reversed PL's effect on cell migration/invasion but not on cell death. Consistently, knocking-down of @entity6 by RNA interference only reversed PL-suppressed @entity3 cell migration. Finally, PL significantly suppressed @entity3 development and activated the ER-MAPKs- @entity6 signaling pathway in @entity3 xenografts in vivo. Taken together, PL selectively killed @entity3 cells and preferentially inhibited @entity3 cell migration/invasion via ROS-ER-MAPKs- @entity6 axis, suggesting a novel therapeutic strategy for the highly malignant and aggressive @entity3 clinically.

title: XXXX selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs- @entity6 .

answer: @entity11


abstract: UNASSIGNED: @entity3 ( @entity3 ) are highly malignant and @entity2 lack of effective therapeutic drugs. @entity11 (PL), a natural product isolated from longer pepper plants, is recently identified as a potent cytotoxic compound highly selective to @entity0 cells. Here, we reported that PL specifically suppressed @entity3 cell migration/invasion via endoplasmic reticulum (ER)-MAPKs- @entity6 signaling pathway. PL selectively killed @entity3 cells but not normal hepatocytes with an IC50 of 10-20   M while PL at much lower concentrations only suppressed @entity3 cell migration/invasion. PL selectively elevated reactive @entity1 species (ROS) in @entity3 cells, which activated or up-regulated downstream @entity10 / @entity9 / @entity5 , @entity4 / @entity8 / @entity7 and @entity6 subsequently. Administration of antioxidants completely abolished PL's effects on cell death and migration/invasion. However, pharmacological inhibition of ER stress-responses or MAPKs signaling pathways with corresponding specific inhibitors only reversed PL's effect on cell migration/invasion but not on cell death. Consistently, knocking-down of @entity6 by RNA interference only reversed PL-suppressed @entity3 cell migration. Finally, PL significantly suppressed @entity3 development and activated the ER-MAPKs- @entity6 signaling pathway in @entity3 xenografts in vivo. Taken together, PL selectively killed @entity3 cells and preferentially inhibited @entity3 cell migration/invasion via ROS-ER-MAPKs- @entity6 axis, suggesting a novel therapeutic strategy for the highly malignant and aggressive @entity3 clinically.

title: @entity11 selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs- XXXX .

answer: @entity6


abstract: BACKGROUND: Culture results affect the diagnosis and treatment of @entity0 with @entity1 . To our knowledge, no previous large-scale study has assessed the relative value of culture methods employed during the evaluation of these conditions. The purpose of this study was to identify an optimal culture strategy for pediatric @entity1 . METHODS: @entity0 with @entity1 were retrospectively studied to assess culture results from the @entity2 site or blood; culture type, including aerobic, anaerobic, fungal, and acid-fast bacteria (AFB); antibiotic exposure history; and clinical history of @entity0 with positive culture results. RESULTS: We studied 869 @entity0 , including 353 with @entity4 , 199 with @entity5 , forty-two with @entity6 , and 275 with abscess. The 4537 cultures processed included 1303 aerobic, 903 anaerobic, 340 fungal, 289 AFB, and 1702 blood. Of 3004 specimens sent during initial work-up, positive results occurred in 677 of 1049 aerobic cultures (64.5%), 140 of 763 blood cultures (18.3%), eighteen of 722 anaerobic cultures (2.5%), five of 251 fungal cultures (2.0%), and two of 219 AFB cultures (0.9%). @entity3 was the most common pathogen isolated, from 428 (50.7%) of 844 @entity0 for whom blood or @entity2 -site culture material was sent (methicillin-resistant @entity3 , 252; and oxacillin-sensitive @entity3 , 176). Cultures were negative in 206 (29.0%) of the 710 @entity0 for whom culture material from the site of @entity2 was sent. @entity0 with true-positive anaerobic, fungal, or AFB cultures had a history of immunocompromise, penetrating inoculation, or failed primary treatment. Antibiotic exposure prior to culture-sample acquisition did not interfere with aerobic culture results from the site of @entity2 . CONCLUSIONS: Our findings suggest that anaerobic, fungal, and AFB cultures should not be routinely performed during the initial evaluation of @entity0 with @entity1 . These cultures should be performed for @entity0 with immunocompromise, clinical suspicion of penetrating inoculation, or failed primary treatment. LEVEL OF EVIDENCE: Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

title: Microbiological culture methods for pediatric XXXX : a guideline for optimal use.

answer: @entity1


abstract: BACKGROUND: @entity10 ( @entity10 ) is a mixed @entity2 characterised by varicose veins, @entity8 , and @entity7 of soft tissue and bone. The purpose of this study was to evaluate the surgical outcomes in @entity10 @entity0 to provide standards for comparison with endovenous therapy. METHODS: The clinical data of consecutive @entity0 with @entity10 who underwent open venous surgical treatment between January 1987 and December 2008 were reviewed. Demographics, clinical presentation, operative data, and clinical outcomes were recorded. Follow-up information was obtained from the medical records, mailed questionnaires and phone calls. Descriptive statistics, the Kaplan-Meier method and Log-rank statistics were used where appropriate. RESULTS: Twenty-seven females and 22 males, (mean age 26.5 years, range 7.7-55.8) were included in this study. All had varicose veins, 36 (73%) had limb @entity7 , and 33 (67%) had @entity3 , with two of three clinical features present in all. The most frequent symptom was @entity1 (N   =   43, 88%). Forty-nine @entity0 underwent operations on 53 limbs. Stripping of the GSV, small and accessory saphenous and lateral embryonic veins was performed in 17 (32%), 10 (19%), 9 (17%), and 15 (28%) limbs, respectively. Two @entity0 developed @entity5 , one had @entity6 ( @entity6 ), and one @entity0 had @entity9 . Freedom from disabling @entity1 at 1, 3 and 5 years was 95%, 77% and 59%, respectively, and freedom from secondary procedures was 78% at 3 years, and 74% at 5 years. At the last follow-up visit, the venous clinical severity score had decreased from 9.48        3.27 to 6.07        3.20 (P   <   0.001). CONCLUSIONS: In selected symptomatic @entity0 with @entity4 , open surgical treatment is safe and durable. Three-fourths of the @entity0 remain free of disabling @entity1 at five years, but secondary procedures are required in one-fourth of the @entity0 . These data can serve as standards for comparison of endovenous therapy for @entity4 .

title: Surgical treatment of varicose veins and XXXX in @entity10 .

answer: @entity8


abstract: BACKGROUND: @entity10 ( @entity10 ) is a mixed @entity2 characterised by varicose veins, @entity8 , and @entity7 of soft tissue and bone. The purpose of this study was to evaluate the surgical outcomes in @entity10 @entity0 to provide standards for comparison with endovenous therapy. METHODS: The clinical data of consecutive @entity0 with @entity10 who underwent open venous surgical treatment between January 1987 and December 2008 were reviewed. Demographics, clinical presentation, operative data, and clinical outcomes were recorded. Follow-up information was obtained from the medical records, mailed questionnaires and phone calls. Descriptive statistics, the Kaplan-Meier method and Log-rank statistics were used where appropriate. RESULTS: Twenty-seven females and 22 males, (mean age 26.5 years, range 7.7-55.8) were included in this study. All had varicose veins, 36 (73%) had limb @entity7 , and 33 (67%) had @entity3 , with two of three clinical features present in all. The most frequent symptom was @entity1 (N   =   43, 88%). Forty-nine @entity0 underwent operations on 53 limbs. Stripping of the GSV, small and accessory saphenous and lateral embryonic veins was performed in 17 (32%), 10 (19%), 9 (17%), and 15 (28%) limbs, respectively. Two @entity0 developed @entity5 , one had @entity6 ( @entity6 ), and one @entity0 had @entity9 . Freedom from disabling @entity1 at 1, 3 and 5 years was 95%, 77% and 59%, respectively, and freedom from secondary procedures was 78% at 3 years, and 74% at 5 years. At the last follow-up visit, the venous clinical severity score had decreased from 9.48        3.27 to 6.07        3.20 (P   <   0.001). CONCLUSIONS: In selected symptomatic @entity0 with @entity4 , open surgical treatment is safe and durable. Three-fourths of the @entity0 remain free of disabling @entity1 at five years, but secondary procedures are required in one-fourth of the @entity0 . These data can serve as standards for comparison of endovenous therapy for @entity4 .

title: Surgical treatment of varicose veins and @entity8 in XXXX .

answer: @entity10


abstract: Growing evidence suggests important roles for specialized platelet-derived growth factor receptor alpha-positive (PDGFRalpha(+)) cells in regulating the behaviors of visceral smooth muscle organs. Examination of the female reproductive tracts of @entity0 and monkeys showed that PDGFRalpha(+) cells form extensive networks in ovary, oviduct, and uterus. PDGFRalpha(+) cells were located in discrete locations within these organs, and their distribution and density were similar in rodents and primates. PDGFRalpha(+) cells were distinct from smooth muscle cells and interstitial cells of Cajal (ICC). This was demonstrated with immunohistochemical techniques and by performing molecular expression studies on PDGFRalpha(+) cells from @entity0 with enhanced green fluorescent protein driven off of the endogenous promoter for Pdgfralpha. Significant differences in gene expression were found in PDGFRalpha(+) cells from ovary, oviduct, and uterus. Differences in gene expression were also detected in cells from different tissue regions within the same organ (e.g., uterine myometrium vs. endometrium). PDGFRalpha(+) cells are unlikely to provide pacemaker activity because they lack significant expression of key pacemaker genes found in ICC (Kit and @entity3 ). @entity2 encoding @entity2 was expressed at relatively high levels in PDGFRalpha(+) cells (except in the ovary), suggesting these cells can form gap junctions to one another and neighboring smooth muscle cells. PDGFRalpha(+) cells also expressed the early response transcription factor and proto-oncogene @entity1 , particularly in the ovary. These data demonstrate extensive distribution of PDGFRalpha(+) cells throughout the female reproductive tract. These cells are a heterogeneous population of cells that are likely to contribute to different aspects of physiological regulation in the various anatomical niches they occupy.

title: A novel class of interstitial cells in the XXXX and monkey female reproductive tracts.

answer: @entity0


abstract: Background. @entity2 ( @entity2 ) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. @entity3 ( @entity3 ) is the major inhibitor of the fibrinolysis and also is part of immune response. The @entity5 gene polymorphism is related to increased @entity3 protein levels. The aim of the study is to evaluate the association of @entity5 @entity3 polymorphism with @entity2 . Methods. A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 @entity0 with diagnosis of @entity2 . Results. The most important risk factor in our population was @entity1 , followed by smoking. The genetic distribution showed an association of the A allele (OR = 1.27, P = 0.04) and AA genotype (OR = 1.86, P = 0.02) with @entity2 . The recessive model displayed similar results (OR = 1.76, P = 0.02). As additional finding, we observed significant differences in the genetic distribution of @entity2 dyslipidemic @entity0 (OR = 1.99, P = 0.04). The A allele and AA genotype of -844 polymorphism of @entity3 gene are risk factors for @entity2 . The AA genotype might be associated with the development of @entity4 in @entity2 @entity0 .

title: The XXXX @entity3 Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population.

answer: @entity5


abstract: Background. @entity2 ( @entity2 ) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. @entity3 ( @entity3 ) is the major inhibitor of the fibrinolysis and also is part of immune response. The @entity5 gene polymorphism is related to increased @entity3 protein levels. The aim of the study is to evaluate the association of @entity5 @entity3 polymorphism with @entity2 . Methods. A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 @entity0 with diagnosis of @entity2 . Results. The most important risk factor in our population was @entity1 , followed by smoking. The genetic distribution showed an association of the A allele (OR = 1.27, P = 0.04) and AA genotype (OR = 1.86, P = 0.02) with @entity2 . The recessive model displayed similar results (OR = 1.76, P = 0.02). As additional finding, we observed significant differences in the genetic distribution of @entity2 dyslipidemic @entity0 (OR = 1.99, P = 0.04). The A allele and AA genotype of -844 polymorphism of @entity3 gene are risk factors for @entity2 . The AA genotype might be associated with the development of @entity4 in @entity2 @entity0 .

title: The @entity5 XXXX Polymorphism Is Associated with Acute Coronary Syndrome in Mexican Population.

answer: @entity3


abstract: BACKGROUND: Trained local screeners assessed the mental-health status of male and female students in Northern Ugandan schools. The study aimed to disclose potential differences in mental health-related impairment in two groups, former @entity0 soldiers (n   =   354) and other war-affected youth (n   =   489), as well as to separate factors predicting @entity5 in learners. METHODS: @entity0 were randomly selected. We used the Post-Traumatic Diagnostic Scale to assess symptoms of @entity4 ( @entity4 ) and for potential @entity3 the respective section of the Hopkins Symptom Checklist with a locally validated cut-off. RESULTS: Almost all respondents had been displaced at least once in their life. 30% of @entity0 and 50% of the @entity0 in the study reported past abduction history. @entity2 exposure was notably higher in the group of abductees. In former @entity0 soldiers, a @entity4 rate of 32% was remarkably higher than that for non-abductees (12%). Especially in @entity0 rates of potential @entity3 were double those in the group of former abductees (17%) than in the group of non-abductees (8%). In all groups, trauma exposure increased the risk of developing @entity4 . A path-analytic model for developing @entity4 and potential @entity3 revealed both previous trauma exposure as well as duration of abduction to have significant influences on trauma-related @entity5 . Findings also suggest that in Northern Ugandan schools @entity1 are common among war-affected learners. CONCLUSIONS: Therefore, it is suggested the school context should be used to provide mental-health support structures within the education system for war-affected youth at likely risk of developing war-related mental distress.

title: From War to Classroom: @entity4 and XXXX in Formerly Abducted Youth in Uganda.

answer: @entity3


abstract: BACKGROUND: Trained local screeners assessed the mental-health status of male and female students in Northern Ugandan schools. The study aimed to disclose potential differences in mental health-related impairment in two groups, former @entity0 soldiers (n   =   354) and other war-affected youth (n   =   489), as well as to separate factors predicting @entity5 in learners. METHODS: @entity0 were randomly selected. We used the Post-Traumatic Diagnostic Scale to assess symptoms of @entity4 ( @entity4 ) and for potential @entity3 the respective section of the Hopkins Symptom Checklist with a locally validated cut-off. RESULTS: Almost all respondents had been displaced at least once in their life. 30% of @entity0 and 50% of the @entity0 in the study reported past abduction history. @entity2 exposure was notably higher in the group of abductees. In former @entity0 soldiers, a @entity4 rate of 32% was remarkably higher than that for non-abductees (12%). Especially in @entity0 rates of potential @entity3 were double those in the group of former abductees (17%) than in the group of non-abductees (8%). In all groups, trauma exposure increased the risk of developing @entity4 . A path-analytic model for developing @entity4 and potential @entity3 revealed both previous trauma exposure as well as duration of abduction to have significant influences on trauma-related @entity5 . Findings also suggest that in Northern Ugandan schools @entity1 are common among war-affected learners. CONCLUSIONS: Therefore, it is suggested the school context should be used to provide mental-health support structures within the education system for war-affected youth at likely risk of developing war-related mental distress.

title: From War to Classroom: XXXX and @entity3 in Formerly Abducted Youth in Uganda.

answer: @entity4


abstract: PURPOSE OF REVIEW: The advent of checkpoint inhibitors has fostered great expectations for long-term outcome in @entity1 @entity0 . Inhibitors of programmed death -1, programmed @entity4 are targets of contemporary @entity1 immunotherapy. Current phase III studies are ongoing and may define a novel treatment paradigm in metastatic @entity3 (mRCC). This review focuses on current clinical data in mRCC. RECENT FINDINGS: Nivolumab and ipilimumab are the most advanced checkpoint inhibitors in the field of mRCC. Current available data include phase I and randomized phase II trials, investigating single agent or combination therapies in mRCC, with objective responses in 20-52% of @entity0 and 19-26 months overall survival in previously treated @entity0 . SUMMARY: Immunotherapies have fostered great expectations on long-term overall survival in mRCC. As seen with previous cytokine treatment, long-term response is a key clinical outcome. Phase III data for previously treated @entity0 are expected later this year and may define a novel standard for treatment. Combinational therapies have generated promising response data, indicating a potential role in treatment intensification in mRCC. Combination treatment is associated with ample @entity2 , which might restrict this approach to selected @entity0 . The major task for the future is to tailor immunotherapy for individual @entity0 .

title: T-cell checkpoint inhibitors in metastatic XXXX .

answer: @entity3


abstract: UNASSIGNED: BACKGROUND We identified an outbreak of AmpC-producing @entity2 infections resistant to third-generation cephalosporins and @entity3 (CR) among 7 @entity0 who had undergone endoscopic retrograde cholangiopancreatography at hospital A during November 2012-August 2013. Gene sequencing revealed a shared novel mutation in a bla CMY gene and a distinctive fumC/ fimH typing profile. OBJECTIVE To determine the extent and epidemiologic characteristics of the outbreak, identify potential sources of transmission, design and implement infection control measures, and determine the association between the CR @entity2 and AmpC @entity2 circulating at hospital A. METHODS We reviewed laboratory, medical, and endoscopy reports, and endoscope reprocessing procedures. We obtained cultures from endoscopes after reprocessing as well as environmental samples and conducted pulsed-field gel electrophoresis and gene sequencing on phenotypic AmpC isolates from @entity0 and endoscopes. Cases were those infected with phenotypic AmpC isolates (both @entity4 -susceptible and CR) and identical bla CMY-2, fumC, and fimH alleles or related pulsed-field gel electrophoresis patterns. RESULTS Thirty-five of 49 AmpC @entity2 tested met the case definition, including all CR isolates. All cases had complicated @entity1 and had undergone at least 1 endoscopic retrograde cholangiopancreatography at hospital A. Mortality at 30 days was 16% for all @entity0 and 56% for CR @entity0 . Two of 8 reprocessed endoscopic retrograde cholangiopancreatography scopes harbored AmpC that matched case isolates by pulsed-field gel electrophoresis. Environmental cultures were negative. No breaches in infection control were identified. Endoscopic reprocessing exceeded manufacturer's recommended cleaning guidelines. CONCLUSION Recommended reprocessing guidelines are not sufficient. Infect Control Hosp Epidemiol 2015;00(0): 1-9.

title: Endoscopic Retrograde Cholangiopancreatography-Associated AmpC XXXX Outbreak.

answer: @entity2


abstract: UNASSIGNED: The goal of the present study was to examine whether @entity1 (WM) capacity allocation is determined solely by complexity, with the number of objects being redundant, as suggested by flexible resource models. @entity0 performed the change detection task with random polygons as stimuli, while we monitored the @entity2 ( @entity2 ), an electrophysiological marker whose amplitude rises as WM load increases. In Experiment 1, we compared the WM maintenance of one whole polygon to a single half of the polygon, equating the number of items but varying the complexity level. Additionally, we compared the whole polygon to two halves of a polygon, thus roughly equating perceptual complexity but manipulating the number of items. The results suggested that only the number of objects determined WM capacity allocation: the @entity2 was identical when comparing one whole polygon to one polygon half, even though these conditions differed in complexity. Furthermore, the @entity2 amplitude was lower in the whole polygon condition relative to the two halves condition, even though both contained roughly the same amount of information. Experiment 2 extended these results by showing that two polygon halves that moved separately but then met and moved together were gradually integrated to consume similar WM capacity as one polygon half. Additionally, in both experiments we found an object benefit in accuracy, corroborating the important role of objects in WM. Our results demonstrate that WM capacity allocation cannot be explained by complexity alone. Instead, it is highly sensitive to objecthood, as suggested by discrete slot models.

title: The number of objects determines XXXX capacity allocation for complex items.

answer: @entity1


abstract: Physical exercise may provide protection against the @entity1 associated with @entity2 , although the mechanisms are not clear. In the present study, APP/ @entity4 double-transgenic and wild-type @entity0 were allowed unlimited @entity3 for 7months. Consistent with previous reports, wheel-running improved cognition in the double- @entity0 . Interestingly, the average daily distance run was strongly correlated with spatial memory in the water maze in wild-type @entity0 (r(2)=.959), but uncorrelated in transgenics (r(2)=.013). Proteomics analysis showed that sedentary @entity0 differed significantly from sedentary wild-types with respect to proteins involved in synaptic transmission, cytoskeletal regulation, and neurogenesis. When given an opportunity to exercise, the transgenics' deficiencies in cytoskeletal regulation and neurogenesis largely normalized, but abnormal synaptic proteins did not change. In contrast, exercise enhanced proteins associated with cytoskeletal regulation, oxidative phosphorylation, and synaptic transmission in wild-type @entity0 . Soluble and insoluble Ab40 and Ab42 levels were significantly decreased in both cortex and hippocampus of active transgenics, suggesting that this may have played a role in the cognitive improvement in APP/ @entity4 @entity0 . b-secretase was significantly reduced in active APP/ @entity4 @entity0 compared to sedentary controls, suggesting a mechanism for reduced Ab. Taken together, these data illustrate that exercise improves memory in wild-type and APP-overexpressing @entity0 in fundamentally different ways.

title: Differential proteomic and behavioral effects of long-term XXXX in wild-type and APP-overexpressing transgenics.

answer: @entity3


abstract: BACKGROUND: @entity1 factor alpha ( @entity3 )-antagonism effectively treats @entity2 ( @entity2 ). The golimumab clinical programme evaluated subcutaneous (SC) and intravenous (IV) induction, and SC maintenance regimens, in @entity3 -antagonist-na  ve @entity0 with moderate-to-severe active @entity2 despite conventional treatment. AIM: To evaluate dose-response relationship, select IV golimumab induction doses for continued development, and evaluate the safety and efficacy of selected doses. METHODS: Adults with Mayo scores of 6-12 and endoscopic subscores >= 2 were enrolled into this multicentre, randomised, double-blind, placebo-controlled, integrated Phase 2/3 dose-finding/dose-confirming study. In Phase 2, 176 @entity0 were randomised (1:1:1:1) to a single IV infusion of placebo, 1-, 2- or 4-mg/kg golimumab. While Phase 2 data were analysed to select doses for continued development, 71 additional @entity0 were randomised. Phase 3 enrolment stopped after 44 additional @entity0 were randomised (1:1:1) to placebo, 2- or 4-mg/kg golimumab. Due to insufficient power for the Phase 3 primary endpoint analysis (clinical response at week 6), efficacy analyses are considered exploratory and include all randomised @entity0 . RESULTS: No dose-response was observed in Phase 2; however, higher serum golimumab exposure was associated with greater proportions of @entity0 achieving more favourable clinical outcomes, clinical response and greater improvement in Mayo scores compared with placebo-treated @entity0 and those with lower serum concentrations. Among all randomised @entity0 , numerically greater proportions were in clinical response at week 6 in the 2- and 4-mg/kg golimumab groups compared with placebo [44.0% (33/75) and 41.6% (32/77) vs. 30.1% (22/73)]. CONCLUSIONS: Efficacy with single-dose golimumab IV induction was lower than expected and less than observed in the SC induction study. No new safety findings were observed. ClinicalTrials.gov Number, NCT00488774.

title: Randomised clinical trial: a placebo-controlled study of intravenous golimumab induction therapy for XXXX .

answer: @entity2


abstract: Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant @entity2 . However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the @entity3 sub-region of the hippocampus, mammillothalamic tract, anterior thalamic nucleus, and entorhinal cortex in an experimental @entity0 model of @entity2 . @entity0 with @entity7 -induced @entity5 were assessed in the object location task with different DBS parameters. Moreover, @entity1 -related side effects were evaluated in the elevated zero maze and open field. After sacrifice, we applied @entity6 immunohistochemistry to assess which memory-related regions were affected by DBS. When comparing all structures, DBS of the entorhinal cortex and @entity3 sub-region was able to restore @entity4 when a specific set of stimulation parameters was used. No @entity1 -related side effects were found following DBS. The beneficial behavioral performance of @entity3 DBS @entity0 was accompanied with an activation of cells in the anterior cingulate gyrus. Therefore, we conclude that acute @entity3 DBS restores @entity4 possibly through improved attentional and cognitive processes in the limbic cortex.

title: Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and XXXX -related functions.

answer: @entity1


abstract: INTRODUCTION: Context effects are described as effects of a given treatment, not directly caused by the treatment itself, but rather caused by the context in which treatment is delivered. Exercise is a recommended core treatment in clinical guidelines for @entity2 . Although moderately effective overall, variation is seen in size of response to exercise across @entity1 ( @entity1 ) studies. Part of this variation may be related to the fact that exercise interventions are performed in different physical environments, which may affect @entity0 differently. The study aims to investigate the effect of exercising in a contextually enhanced physical environment for 8   weeks in @entity0 with knee or @entity3 . METHODS AND ANALYSIS: The study is a double-blind @entity1 . Eligible @entity0 are 35   years or older with persisting knee and/or @entity3 for 3   months. @entity0 are randomised to one of three groups: (1) exercise in a contextually enhanced environment, (2) exercise in a standard environment and (3) waiting list. The contextually enhanced environment is located in a newly built facility, has large windows providing abundant daylight and overlooks a recreational park. The standard environment is in a basement, has artificial lighting and is marked by years of use; that is, resembling many clinical environments. The primary outcome is the @entity0 's global perceived effect rated on a seven-point Likert scale after 8   weeks exercise. @entity0 -reported and objective secondary outcomes are included. ETHICS AND DISSEMINATION: The Regional Scientific Ethical Committee for Southern Denmark has approved the study. Study findings will be disseminated in peer-reviewed publications and presented at national and international conferences. TRIAL REGISTRATION NUMBER: NCT02043613.

title: Exploring the effect of space and place on response to exercise therapy for knee and XXXX -a protocol for a double-blind randomised controlled clinical trial: the CONEX trial.

answer: @entity3


abstract: AIMS: To calculate the @entity2 -attributable fraction (AAF) of injury morbidity by volume of consumption prior to injury based on newly reported relative risk (RR) estimates. DESIGN: AAF estimates based on the dose-response RR estimates obtained from previous pair-matched case-crossover fractional polynomial analysis of mean volume in volume categories were calculated from the prevalence of drinking prior to injury in each volume category. SETTING: Thirty-seven @entity3 ( @entity3 ) across 18 countries. @entity0 : Probability samples of @entity0 , with equal representation of each shift for each day of the week, totaling 14,026 who arrived at the @entity4 within six hours of injury from @entity4 studies conducted between 2001 and 2011. MEASUREMENTS: AAF was analyzed by gender, age (18-30; >30), cause of injury (traffic, assault, fall, other), and country @entity5 ( @entity5 ). FINDINGS: For the @entity3 analyzed, 16.4% of all @entity1 were estimated to be attributable to @entity2 , and the AAF did not vary by age but was over twice as large for males (20.6%; 19.3-21.8) than for females (8.6%; 7.5-9.7%). While females were at greater risk of injury than males at higher volume levels, lower prevalence of @entity0 drinking at higher levels contributed to overall lower AAF for @entity0 . Assault-related @entity1 showed the largest AAF (44.1%; 37.6-42.6). AAF was slightly higher for @entity1 from falls (14.3%; 12.9-15.7) than motor vehicle crashes (11.1%; 9.3-12.9). AAF was higher in those countries with a @entity5 of 3 (18.6; 17.5-19.7) and 4 (19.4%; 17.3-21.6) than those with a @entity5 of 2 (12.0%; 10.5-13.5). CONCLUSIONS: @entity2 -attributable @entity1 presenting in @entity3 are higher for males than females, for violence-related @entity1 compared with other types of injury, and for countries with more detrimental drinking patterns compared with those with less detrimental patterns.

title: XXXX Attributable Fraction for Injury Morbidity from the Dose-Response Relationship of Acute @entity2 Consumption: Emergency Department Data from 18 Countries.

answer: @entity2


abstract: AIMS: To calculate the @entity2 -attributable fraction (AAF) of injury morbidity by volume of consumption prior to injury based on newly reported relative risk (RR) estimates. DESIGN: AAF estimates based on the dose-response RR estimates obtained from previous pair-matched case-crossover fractional polynomial analysis of mean volume in volume categories were calculated from the prevalence of drinking prior to injury in each volume category. SETTING: Thirty-seven @entity3 ( @entity3 ) across 18 countries. @entity0 : Probability samples of @entity0 , with equal representation of each shift for each day of the week, totaling 14,026 who arrived at the @entity4 within six hours of injury from @entity4 studies conducted between 2001 and 2011. MEASUREMENTS: AAF was analyzed by gender, age (18-30; >30), cause of injury (traffic, assault, fall, other), and country @entity5 ( @entity5 ). FINDINGS: For the @entity3 analyzed, 16.4% of all @entity1 were estimated to be attributable to @entity2 , and the AAF did not vary by age but was over twice as large for males (20.6%; 19.3-21.8) than for females (8.6%; 7.5-9.7%). While females were at greater risk of injury than males at higher volume levels, lower prevalence of @entity0 drinking at higher levels contributed to overall lower AAF for @entity0 . Assault-related @entity1 showed the largest AAF (44.1%; 37.6-42.6). AAF was slightly higher for @entity1 from falls (14.3%; 12.9-15.7) than motor vehicle crashes (11.1%; 9.3-12.9). AAF was higher in those countries with a @entity5 of 3 (18.6; 17.5-19.7) and 4 (19.4%; 17.3-21.6) than those with a @entity5 of 2 (12.0%; 10.5-13.5). CONCLUSIONS: @entity2 -attributable @entity1 presenting in @entity3 are higher for males than females, for violence-related @entity1 compared with other types of injury, and for countries with more detrimental drinking patterns compared with those with less detrimental patterns.

title: @entity2 Attributable Fraction for Injury Morbidity from the Dose-Response Relationship of Acute XXXX Consumption: Emergency Department Data from 18 Countries.

answer: @entity2


abstract: BACKGROUND: Chemical fibrinolysis has been shown to be as effective as surgical debridement for the treatment of pediatric @entity5 . However, no studies effectively evaluate antibiotic treatment. We evaluated antibiotic utilization among different treatments of pediatric @entity5 . METHODS: This is a retrospective review of 169 @entity5 @entity0 who underwent chemical and/or mechanical fibrinolysis at a dedicated @entity0 's hospital from 2005-2013. Data points included duration of therapy, cultures, presence of @entity1 or @entity3 , and adverse drug reactions. Immunocompromised @entity0 and those with additional foci of @entity2 were excluded. RESULTS: Twenty-seven @entity0 underwent video-assisted thoracoscopic surgery (VATS), 123 had chemical fibrinolysis via tube thoracostomy with @entity4 (tPA), and 19 had tPA followed by VATS. The mean (  standard deviation) duration of total antibiotic therapy was 25.7      6.5  d; following a 24  h afebrile period of 19.4      6.3  d. @entity0 who had tPA had a significantly shorter duration of parenteral antibiotic therapy when compared with primary VATS (9.2      3.6  d versus 11.6      5.5  d, P = 0.04) and VATS following tPA (9.2      3.6  d versus 14.3      8.1  d, P  <  0.01). @entity0 with @entity1 or @entity3 (n  =  26) had an increased total duration of antibiotics (29.3      5.7  d versus 25.1      6.4  d, P  <  0.01). Seventy @entity0 (41%) had an adverse reaction related to antibiotic use. CONCLUSIONS: @entity0 with @entity5 currently receive a protracted variable course of antibiotic therapy influenced by primary treatment and the presence of @entity1 or @entity3 . With a high incidence of adverse reactions, a standardized protocol with truncated treatment duration should be considered.

title: Antibiotic utilization based on primary treatment of pediatric XXXX .

answer: @entity5


abstract: BACKGROUND: Although adjuvant chemotherapy is a standard treatment in @entity1 , its benefit is not as clear for stage II @entity0 . In this retrospective analysis, we aimed to evaluate the survival of @entity0 with @entity1 , the efficacy of adjuvant chemotherapy in high-risk @entity1 @entity0 , and prognostic factors in @entity2 . MATERIALS AND METHODS: One hundred and seventeen @entity0 who were diagnosed with @entity1 between January 2006 and December 2011 were included in the study. @entity0 were stratified into two groups as being low-risk and high-risk according to risk factors for @entity2 . Adjuvant @entity3 -based chemotherapy were administered to the @entity0 with risk factors. RESULTS: Ninety-four @entity0 were treated with adjuvant chemotherapy due to high risk factors and 23 were monitored without treatment. Median follow-up time was 43 months. In terms of disease free survival and overall survival, adjuvant chemotherapy did not provide a statistically significant difference. Univariate analysis demonstrated that @entity4 was the major risk factor for shortened disease-free survival, while bowel perforation and perineural invasion were both negative prognostic factors for overall survival. CONCLUSIONS: The recommendation of adjuvant chemotherapy for @entity1 is not clear. In our study, it was found that adjuvant chemotherapy did not contribute to survival in high-risk stage II @entity0 . Due to the fact that prognosis of stage II @entity0 is good, many more @entity0 will be needed for statistically significant differences in survival. Adjuvant chemotherapy containing 5 @entity3 is being used to high-risk stage II @entity0 although it is not a standard treatment approach.

title: Adjuvant Chemotherapy and Prognostic Factors in XXXX - Izmir Oncology Group Study.

answer: @entity1


abstract: BACKGROUND: The Quality Audit (BQA) program of the Breast Surgeons of Australia and New Zealand (NZ) collects data on early female @entity0 and its treatment. BQA data covered approximately half all early @entity0 diagnosed in NZ during roll-out of the BQA program in 1998-2010. Coverage increased progressively to about 80% by 2008. This is the biggest NZ @entity0 database outside the NZ Cancer Registry and it includes @entity2 and clinical management data not collected by the Registry. We used these BQA data to compare socio-demographic and @entity2 characteristics and survivals by ethnicity. MATERIALS AND METHODS: BQA data for 1998-2010 diagnoses were linked to NZ death records using the National Health Index (NHI) for linking. Live cases were followed up to December 31st 2010. Socio-demographic and invasive @entity2 characteristics and disease-specific survivals were compared by ethnicity. RESULTS: Five-year survivals were 87% for Maori, 84% for Pacific, 91% for other NZ cases and 90% overall. This compared with the 86% survival reported for all female breast cases covered by the NZ Cancer Registry which also included more advanced stages. Patterns of survival by clinical risk factors accorded with patterns expected from the scientific literature. Compared with Other cases, Maori and Pacific @entity1 were younger, came from more deprived areas, and had @entity2 with more ductal and fewer lobular histology types. Their @entity2 were also less likely to have a triple negative phenotype. More of the Pacific @entity1 had @entity3 . Maori @entity1 were more likely to reside in areas more remote from regional @entity2 centres, whereas Pacific @entity1 generally lived closer to these centres than Other NZ cases. CONCLUSIONS: NZ BQA data indicate previously unreported differences in @entity0 biology by ethnicity. Maori and Pacific @entity1 had @entity0 survival compared with Other NZ @entity1 , after adjusting for socio-demographic and @entity2 characteristics. The potential contributions to survival differences of variations in service access, timeliness and quality of care, need to be examined, along with effects of co- morbidity and biological factors.

title: XXXX Characteristics and Survival Differences between Maori, Pacific and other New Zealand @entity1 Included in the Quality Audit Program of Breast Surgeons of Australia and New Zealand.

answer: @entity0


abstract: BACKGROUND: The Quality Audit (BQA) program of the Breast Surgeons of Australia and New Zealand (NZ) collects data on early female @entity0 and its treatment. BQA data covered approximately half all early @entity0 diagnosed in NZ during roll-out of the BQA program in 1998-2010. Coverage increased progressively to about 80% by 2008. This is the biggest NZ @entity0 database outside the NZ Cancer Registry and it includes @entity2 and clinical management data not collected by the Registry. We used these BQA data to compare socio-demographic and @entity2 characteristics and survivals by ethnicity. MATERIALS AND METHODS: BQA data for 1998-2010 diagnoses were linked to NZ death records using the National Health Index (NHI) for linking. Live cases were followed up to December 31st 2010. Socio-demographic and invasive @entity2 characteristics and disease-specific survivals were compared by ethnicity. RESULTS: Five-year survivals were 87% for Maori, 84% for Pacific, 91% for other NZ cases and 90% overall. This compared with the 86% survival reported for all female breast cases covered by the NZ Cancer Registry which also included more advanced stages. Patterns of survival by clinical risk factors accorded with patterns expected from the scientific literature. Compared with Other cases, Maori and Pacific @entity1 were younger, came from more deprived areas, and had @entity2 with more ductal and fewer lobular histology types. Their @entity2 were also less likely to have a triple negative phenotype. More of the Pacific @entity1 had @entity3 . Maori @entity1 were more likely to reside in areas more remote from regional @entity2 centres, whereas Pacific @entity1 generally lived closer to these centres than Other NZ cases. CONCLUSIONS: NZ BQA data indicate previously unreported differences in @entity0 biology by ethnicity. Maori and Pacific @entity1 had @entity0 survival compared with Other NZ @entity1 , after adjusting for socio-demographic and @entity2 characteristics. The potential contributions to survival differences of variations in service access, timeliness and quality of care, need to be examined, along with effects of co- morbidity and biological factors.

title: @entity0 Characteristics and Survival Differences between Maori, Pacific and other New Zealand XXXX Included in the Quality Audit Program of Breast Surgeons of Australia and New Zealand.

answer: @entity1


abstract: PURPOSE: Torsion angle determines the incidence of @entity2 among @entity0 with @entity3 . The purpose of this study was to evaluate the association between torsion angle and findings on CT scan. MATERIALS AND METHODS: We retrospectively reviewed CT scan findings obtained less than 36  h before surgery for 31 @entity0 with @entity3 . Ovarian torsion angles measured intraoperatively ranged from 90   to 1260  . Ovaries with torsion angles less than 360   rarely develop @entity2 . @entity0 were divided into two groups according to torsion angle:  <360   (Group A) and  >= 360   (Group B). A lesion corresponding to an @entity4 and mesovarium containing dilated veins between the uterus and twisted ovary is referred to as a "mass-like @entity1 ". RESULTS: A mass-like @entity1 occurred more often in Group B (p  <  0.05) and had the highest correlation with torsion angles  >= 360  . A mass-like @entity1 lacking enhancement or a high-density area was significantly different between the groups (p  <  0.05) and was also indicative of torsion angles  >= 360  . CONCLUSION: A mass-like @entity1 alone or with a high-density area or lack of enhancement suggests an @entity3 angle  >= 360  . The presence of these findings predict @entity3 and may allow ovary-sparing treatment.

title: CT prediction of the degree of XXXX .

answer: @entity3


abstract: Disruption of the pancreatic islet environment combined with the decrease in @entity0 supply that occurs during isolation leads to poor islet survival. The aim of this study was to validate the benefit of using a plasma-based scaffold supplemented with @entity7 to improve islet transplantation outcome. @entity2 islets were cultured in three conditions: i) control group, ii) plasma based-matrix (P-matrix), and iii) P-matrix supplemented with emulsified perfluorodecalin. After 24  h culture, matrix/cell contacts (Integrinb1, p- @entity3 / @entity3 , p- @entity4 / @entity4 ), survival ( @entity5 , TUNEL, FDA/PI), function, and @entity6 translocation were assessed. Afterwards, P-matrices were dissolved and the islets were intraportally transplanted. Graft function was monitored for 31 days with glycaemia and C-peptide follow up. @entity1 was assessed by histology (macrophage and granulocyte staining) and thrombin/anti-thrombin complex measurement. Islet survival correlated with an increase in integrin, @entity3 , and @entity4 activation in P-matrices and function was maintained. @entity7 supplementation decreased translocation of @entity6 in the nucleus and post-transplantation islet structure was better preserved in P-matrices, but a quicker activation of IBMIR resulted in early loss of graft function. "Oxygenating" P-matrices provided a real benefit to islet survival and resistance in  vivo. However, intraportal transplantation is not suitable for this kind of culture due to IBMIR; thus, alternative sites must be explored.

title: Impact of an autologous oxygenating matrix culture system on XXXX islet transplantation outcome.

answer: @entity2


abstract: A new model of stretch-induced growth is evaluated in four @entity1 wing muscles stretched to different extents by a spring-loaded tubular assembly. Muscles grew in length and cross section in proportion to the extent to which they were stretched. Longitudinal growth was essentially completed within 1 wk, while muscles grew in cross section through at least 5 wk of stretch. The muscles were neither denervated nor immobilized, and muscle activity as measured by EMG was not increased. Oxidative enzyme activities increased substantially with stretch in the patagialis (PAT), a twitch muscle, but were relatively unchanged in the slow-tonic @entity0 ( @entity0 ). Stretch altered mitochondrial enzyme proportions in the PAT, but had little effect in the @entity0 . Capillary density was unchanged with stretch in the PAT, but decreased in the @entity0 . Capillary density was unchanged with stretch in the PAT, but decreased in the @entity0 . Capillary-to-fiber ratio, however, increased in both muscles. We conclude that muscles grow and adapt enzymatically due to stretch, but that these responses are dissimilar in twitch and tonic muscles.

title: Stretch-induced growth in XXXX wing muscles: a new model of stretch hypertrophy.

answer: @entity1


abstract: @entity13 @entity1 / @entity3 ( @entity13 /C) is an @entity2 caused by defective desmosomal proteins, and it has typical histopathological features characterized by predominantly progressive @entity10 of the right ventricle. Clinical presentations of @entity13 /C vary from @entity6 , progressive @entity5 ( @entity5 ), @entity8 , and @entity7 ( @entity7 ). The 2010 modified Task Force criteria were established to facilitate the recognition and diagnosis of @entity13 /C. An @entity4 ( @entity4 ) remains to be the cornerstone in prevention of @entity7 in @entity0 fulfilling the diagnosis of definite @entity13 /C, especially among @entity13 /C @entity0 with @entity6 , hemodynamically unstable @entity8 ( @entity8 ), @entity11 , and aborted @entity7 . Further risk stratification is clinically valuable in the management of @entity0 with borderline or possible @entity13 /C and mutation carriers of family members. However, given the entity of heterogeneous penetrance and non-uniform phenotypes, the standardization of clinical practice guidelines for at-risk individuals will be the next frontier to breakthrough. Antiarrhythmic drugs are prescribed frequently to @entity0 experiencing frequent @entity14 . @entity12 is the recommended drug of choice. @entity9 ( @entity9 ) has been demonstrated to effectively eliminate the drug-refractory @entity8 in @entity0 with @entity13 /C. However, the efficacy and clinical prognosis of @entity9 via endocardial approach alone was disappointing prior to the era of epicardial approach. In recent years, it has been proven that the integration of endocardial and epicardial ablation by targeting the critical isthmus or eliminating abnormal electrograms within the diseased substrates could yield higher acute success and lower recurrence of @entity8 during long-term follow-up. Heart transplantation is the final option for @entity0 with extensive disease, biventricular @entity5 with uncontrollable hemodynamic compromise, and refractory @entity8 despite aggressive medical and ablation therapies.

title: Current and state of the art on the electrophysiologic characteristics and catheter ablation of arrhythmogenic right XXXX / @entity3 .

answer: @entity1


abstract: @entity13 @entity1 / @entity3 ( @entity13 /C) is an @entity2 caused by defective desmosomal proteins, and it has typical histopathological features characterized by predominantly progressive @entity10 of the right ventricle. Clinical presentations of @entity13 /C vary from @entity6 , progressive @entity5 ( @entity5 ), @entity8 , and @entity7 ( @entity7 ). The 2010 modified Task Force criteria were established to facilitate the recognition and diagnosis of @entity13 /C. An @entity4 ( @entity4 ) remains to be the cornerstone in prevention of @entity7 in @entity0 fulfilling the diagnosis of definite @entity13 /C, especially among @entity13 /C @entity0 with @entity6 , hemodynamically unstable @entity8 ( @entity8 ), @entity11 , and aborted @entity7 . Further risk stratification is clinically valuable in the management of @entity0 with borderline or possible @entity13 /C and mutation carriers of family members. However, given the entity of heterogeneous penetrance and non-uniform phenotypes, the standardization of clinical practice guidelines for at-risk individuals will be the next frontier to breakthrough. Antiarrhythmic drugs are prescribed frequently to @entity0 experiencing frequent @entity14 . @entity12 is the recommended drug of choice. @entity9 ( @entity9 ) has been demonstrated to effectively eliminate the drug-refractory @entity8 in @entity0 with @entity13 /C. However, the efficacy and clinical prognosis of @entity9 via endocardial approach alone was disappointing prior to the era of epicardial approach. In recent years, it has been proven that the integration of endocardial and epicardial ablation by targeting the critical isthmus or eliminating abnormal electrograms within the diseased substrates could yield higher acute success and lower recurrence of @entity8 during long-term follow-up. Heart transplantation is the final option for @entity0 with extensive disease, biventricular @entity5 with uncontrollable hemodynamic compromise, and refractory @entity8 despite aggressive medical and ablation therapies.

title: Current and state of the art on the electrophysiologic characteristics and catheter ablation of arrhythmogenic right @entity1 / XXXX .

answer: @entity3


abstract: UNASSIGNED: The study was designed to formulate intravaginal devices that provide biologically active circulating concentrations of an aromatase inhibitor for a minimum of 4 days, and to determine their physiologic effects in @entity1 . Three compounds with @entity0 inhibitory capability ( @entity3 , @entity4 and @entity5 ) were tested in vitro using @entity1 granulosa cell culture. @entity3 was found to be the most efficient and potent inhibitor. A wax-based vehicle was selected for further development of a @entity3 intravaginal device based on its steady release rate. Cycling heifers were assigned randomly to be given an intravaginal device containing wax plus gel coat (n=4), wax formulation (n=4), no formulation (blank device, control, n=4). Intravaginal devices were inserted on Day 3 (Day 0=ovulation) and kept in place for 8 days. The addition of a @entity3 -containing gel coating hastened the initial increase on plasma concentrations, while the @entity3 -containing wax-based vehicle maintained prolonged delivery from the intravaginal device. The dominant follicle diameter profile was larger in heifers treated with the wax plus gel coat device (P<0.04), and the interwave interval was prolonged in heifers in the @entity3 -treated groups compared to controls (P<0.001). Plasma @entity0 concentrations were reduced significantly in the @entity3 -treated groups. Plasma @entity2 concentrations were lower in the wax @entity3 -treated group (P<0.02). We concluded that wax base plus gel coat intravaginal devices are suitable for the development of a @entity3 -based protocol for the synchronization of ovulation in @entity1 . It effectively reduced @entity0 production resulting in prolonged dominant follicle growth and lifespan, without adversely affecting @entity2 production.

title: Formulation and testing of a non-steroidal aromatase inhibitor intravaginal device for the control of ovarian function in XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity13 is currently ranked as the second, most frequently isolated etiological factor of @entity0 @entity1 , next only to @entity9 . In comparison to @entity9 , @entity13 shows lower susceptibility to @entity14 , the most common agents used in treatment of @entity1 . Interestingly, the mechanisms of resistance to @entity11 agents in @entity9 have been much better investigated than those in @entity13 . The aim of the presented study was to determine the mechanisms of resistance to @entity14 in 81 @entity13 clinical isolates from three different hospitals in Poland. The investigation carried out with Sensititre @entity2 One test revealed that 18 strains were resistant to @entity6 , and 15 of them were cross-resistant to all other @entity14 tested ( @entity8 , @entity12 and @entity4 ). One isolate resistant to @entity6 was cross-resistant to @entity8 , and resistance to @entity8 only was observed in six other isolates. All strains were found susceptible to @entity10 and @entity5 , and five were classified as resistant to @entity7 . The sequence of ERG11 gene coding for @entity15 14-a demethylase (the molecular target of @entity14 ) of 41 isolates, including all strains resistant to @entity6 and three resistant only to @entity8 , was determined, and no @entity3 substitutions were found. Real-time PCR studies revealed that the resistant strains showed up-regulation of the CDR1 gene coding for the efflux pump. No up-regulation of the expression of CDR2 nor ERG11 genes was observed.

title: Mechanisms of XXXX resistance among clinical isolates of @entity13 in Poland.

answer: @entity11


abstract: UNASSIGNED: @entity13 is currently ranked as the second, most frequently isolated etiological factor of @entity0 @entity1 , next only to @entity9 . In comparison to @entity9 , @entity13 shows lower susceptibility to @entity14 , the most common agents used in treatment of @entity1 . Interestingly, the mechanisms of resistance to @entity11 agents in @entity9 have been much better investigated than those in @entity13 . The aim of the presented study was to determine the mechanisms of resistance to @entity14 in 81 @entity13 clinical isolates from three different hospitals in Poland. The investigation carried out with Sensititre @entity2 One test revealed that 18 strains were resistant to @entity6 , and 15 of them were cross-resistant to all other @entity14 tested ( @entity8 , @entity12 and @entity4 ). One isolate resistant to @entity6 was cross-resistant to @entity8 , and resistance to @entity8 only was observed in six other isolates. All strains were found susceptible to @entity10 and @entity5 , and five were classified as resistant to @entity7 . The sequence of ERG11 gene coding for @entity15 14-a demethylase (the molecular target of @entity14 ) of 41 isolates, including all strains resistant to @entity6 and three resistant only to @entity8 , was determined, and no @entity3 substitutions were found. Real-time PCR studies revealed that the resistant strains showed up-regulation of the CDR1 gene coding for the efflux pump. No up-regulation of the expression of CDR2 nor ERG11 genes was observed.

title: Mechanisms of @entity11 resistance among clinical isolates of XXXX in Poland.

answer: @entity13


abstract: @entity3 is an uncommon @entity0 that primarily occurs in the long bones of the lower and upper extremities. Only 2% involve the mandible, and the maxilla is involved one eighth as often as the mandible. The most common site of metastases is the lung. Increasing @entity2 is the most common presenting symptom. A case of mandibular involvement is presented. The combination of a large, soft tissue mass adjacent to an area of @entity1 in a young male should suggest the diagnosis. The previously poor five- and ten-year survival rates of 8 and 4% respectively, may have promise of marked improvement. This improvement lies in a changing philosophy of treatment. Four-drug chemotherapy combined with prophylactic whole-lung irradiation has been added to local irradiation of the @entity0 bed. Five-year survival figures of 20 to 30% appear obtainable. Although extensive surgical resection of the @entity0 in the long bones has for the most part been replaced by local irradiation for control, surgery in mandibular cases may still be the treatment of choice.

title: XXXX of the mandible.

answer: @entity3


abstract: @entity4 and @entity2 are examples of task-specific @entity1 . Recently, the @entity5 ( @entity5 ) locus was suggested to be associated with @entity4 and @entity2 by a genome-wide association study. To test for the presence of causal variants, the entire coding region and exon-intron boundaries of @entity5 were sequenced in DNA samples from 158 @entity4 @entity0 which were collected at the University of Music, Drama, and Media (Hanover, Germany), and 72 @entity0 with @entity2 which were recruited at the Academic Medical Centers in Amsterdam and Groningen, the Netherlands. The frequency of variants within @entity5 was compared to publically available data at the exome variant server (EVS) from the NHLBI GO Exome Sequencing Project. We identified 11 single @entity3 variants (SNVs) in the @entity0 including eight non-synonymous substitutions. All variants have previously been reported at EVS including two SNVs with a reported minor allele frequency <1  %. One rare missense variant, @entity6 ( @entity7 ), was significantly enriched in the group of @entity2 @entity0 compared to European Americans in EVS database (p  =  0.0013). In @entity0 with @entity2 , there was an overall enrichment for rare, protein-changing variants compared to controls (p  <  0.01). In conclusion, we did not detect any conclusive mutation in @entity5 . However, we showed an association with @entity6 in @entity0 with @entity2 that contributed to an overall enrichment for rare, protein-changing variants in these @entity0 . Thus, our data provide further support for a role of @entity5 variants in task-specific @entity1 , especially @entity2 .

title: Accumulation of rare variants in the XXXX ( @entity5 ) gene in task-specific @entity1 .

answer: @entity5


abstract: @entity4 and @entity2 are examples of task-specific @entity1 . Recently, the @entity5 ( @entity5 ) locus was suggested to be associated with @entity4 and @entity2 by a genome-wide association study. To test for the presence of causal variants, the entire coding region and exon-intron boundaries of @entity5 were sequenced in DNA samples from 158 @entity4 @entity0 which were collected at the University of Music, Drama, and Media (Hanover, Germany), and 72 @entity0 with @entity2 which were recruited at the Academic Medical Centers in Amsterdam and Groningen, the Netherlands. The frequency of variants within @entity5 was compared to publically available data at the exome variant server (EVS) from the NHLBI GO Exome Sequencing Project. We identified 11 single @entity3 variants (SNVs) in the @entity0 including eight non-synonymous substitutions. All variants have previously been reported at EVS including two SNVs with a reported minor allele frequency <1  %. One rare missense variant, @entity6 ( @entity7 ), was significantly enriched in the group of @entity2 @entity0 compared to European Americans in EVS database (p  =  0.0013). In @entity0 with @entity2 , there was an overall enrichment for rare, protein-changing variants compared to controls (p  <  0.01). In conclusion, we did not detect any conclusive mutation in @entity5 . However, we showed an association with @entity6 in @entity0 with @entity2 that contributed to an overall enrichment for rare, protein-changing variants in these @entity0 . Thus, our data provide further support for a role of @entity5 variants in task-specific @entity1 , especially @entity2 .

title: Accumulation of rare variants in the @entity5 ( XXXX ) gene in task-specific @entity1 .

answer: @entity5


abstract: @entity4 and @entity2 are examples of task-specific @entity1 . Recently, the @entity5 ( @entity5 ) locus was suggested to be associated with @entity4 and @entity2 by a genome-wide association study. To test for the presence of causal variants, the entire coding region and exon-intron boundaries of @entity5 were sequenced in DNA samples from 158 @entity4 @entity0 which were collected at the University of Music, Drama, and Media (Hanover, Germany), and 72 @entity0 with @entity2 which were recruited at the Academic Medical Centers in Amsterdam and Groningen, the Netherlands. The frequency of variants within @entity5 was compared to publically available data at the exome variant server (EVS) from the NHLBI GO Exome Sequencing Project. We identified 11 single @entity3 variants (SNVs) in the @entity0 including eight non-synonymous substitutions. All variants have previously been reported at EVS including two SNVs with a reported minor allele frequency <1  %. One rare missense variant, @entity6 ( @entity7 ), was significantly enriched in the group of @entity2 @entity0 compared to European Americans in EVS database (p  =  0.0013). In @entity0 with @entity2 , there was an overall enrichment for rare, protein-changing variants compared to controls (p  <  0.01). In conclusion, we did not detect any conclusive mutation in @entity5 . However, we showed an association with @entity6 in @entity0 with @entity2 that contributed to an overall enrichment for rare, protein-changing variants in these @entity0 . Thus, our data provide further support for a role of @entity5 variants in task-specific @entity1 , especially @entity2 .

title: Accumulation of rare variants in the @entity5 ( @entity5 ) gene in task-specific XXXX .

answer: @entity1


abstract: UNASSIGNED: Pathogens are sensed by innate immune receptors that initiate an efficient adaptive immune response upon activation. The elements of the innate immune recognition process for @entity6 include TLR-2, TLR-4, and dectin-1. However, there are additional receptors necessary for the host immune responses to @entity6 . The @entity2 -binding oligomerization domain-like receptor (NLRs), which activate inflammasomes, are candidate receptors that deserve renewed investigation. After pathogen @entity1 , the NLRs form large signaling platforms called inflammasomes, which lead to @entity7 activation and maturation of proinflammatory cytokines ( @entity4 and IL-1b). In this study, we showed that NLR family pyrin domain-containing 3 ( @entity5 ) is required to induce @entity7 activation and further secretion of IL-1b and @entity4 by @entity6 -infected macrophages. Additionally, @entity3 efflux and lysosomal acidification induced by the fungus were important steps in the @entity7 activation mechanism. Notably, @entity5 and @entity7 knockout @entity0 were more susceptible to @entity1 than were the wild-type animals, suggesting that the @entity5 -dependent inflammasomes contribute to host protection against @entity6 . This protective effect occurred owing to the inflammatory response mediated by @entity4 , as shown by an augmented fungus burden in @entity4 knockout @entity0 . Taken together, our results show that the @entity5 inflammasome is essential for resistance against @entity6 because it orchestrates robust @entity7 activation and triggers an @entity4 -dependent proinflammatory response.

title: XXXX Triggered by the @entity5 Inflammasome Induces Host Innate Resistance in a Pulmonary Model of Fungal Infection.

answer: @entity4


abstract: UNASSIGNED: Pathogens are sensed by innate immune receptors that initiate an efficient adaptive immune response upon activation. The elements of the innate immune recognition process for @entity6 include TLR-2, TLR-4, and dectin-1. However, there are additional receptors necessary for the host immune responses to @entity6 . The @entity2 -binding oligomerization domain-like receptor (NLRs), which activate inflammasomes, are candidate receptors that deserve renewed investigation. After pathogen @entity1 , the NLRs form large signaling platforms called inflammasomes, which lead to @entity7 activation and maturation of proinflammatory cytokines ( @entity4 and IL-1b). In this study, we showed that NLR family pyrin domain-containing 3 ( @entity5 ) is required to induce @entity7 activation and further secretion of IL-1b and @entity4 by @entity6 -infected macrophages. Additionally, @entity3 efflux and lysosomal acidification induced by the fungus were important steps in the @entity7 activation mechanism. Notably, @entity5 and @entity7 knockout @entity0 were more susceptible to @entity1 than were the wild-type animals, suggesting that the @entity5 -dependent inflammasomes contribute to host protection against @entity6 . This protective effect occurred owing to the inflammatory response mediated by @entity4 , as shown by an augmented fungus burden in @entity4 knockout @entity0 . Taken together, our results show that the @entity5 inflammasome is essential for resistance against @entity6 because it orchestrates robust @entity7 activation and triggers an @entity4 -dependent proinflammatory response.

title: @entity4 Triggered by the XXXX Inflammasome Induces Host Innate Resistance in a Pulmonary Model of Fungal Infection.

answer: @entity5


abstract: OBJECTIVE: To test the hypothesis that a new surgical technique using elaborated perineal anastomotic urethroplasty combined with laparoscopic omentoplasty for @entity0 with complex and prior failed @entity2 repair was feasible, safe, and effective. METHODS: We performed a prospective, observational, stage 2a study to observe treatment outcomes of combined perineal and laparoscopic approach for urethroplasty in @entity0 with @entity2 at a single center in Pune, India, between January 2012 and February 2013. Complex and redo @entity0 with @entity2 occurring after @entity2 @entity1 were included in the study. @entity4 were excluded. The primary study outcome was the success rate of the surgical technique, and the secondary outcome was to evaluate feasibility and safety of the procedure. The clinical outcome was considered a failure when any postoperative instrumentation was needed. RESULTS: Fifteen male @entity0 with a median age of 19 years were included in the study. Seven @entity0 were adolescents (12-18 years) and 8 @entity0 (53.3%) were adults (19-49 years). The mean number of prior urethroplasties was 1.8 (range, 1-3). All @entity0 underwent @entity3 using a perineal approach with inferior pubectomy combined with laparoscopic mobilization of the omentum into the perineum to envelope the @entity3 and to fill the perineal dead space. Of 15 @entity0 , 14 (93.3%) were successful and 1 (6.6%) failed. One adolescent @entity0 14 years old developed a recurrent stricture 2 months after the procedure and was managed using internal urethrotomy. Median follow-up was 18 months (range, 13-24 months). CONCLUSION: Combining a laparoscopic omentoplasty to a membranobulbar @entity3 for complex and redo @entity2 @entity1 is successful, feasible, safe, and with minimal additional morbidity to the @entity0 . The technique has the advantage of a perineal incision and the ability to use the omentum to support the @entity3 .

title: Laparoscopic omentoplasty to support anastomotic urethroplasty in complex and redo XXXX .

answer: @entity2


abstract: BACKGROUND: Isoperistaltic stapled side-to-side @entity1 (SSSA), which is a modified technique from conventional antiperistaltic SSSA, has the benefits of antiperistaltic SSSA but requires less intestinal mobility. The aim of this randomized controlled trial was to evaluate short-term outcomes of isoperistaltic SSSA comparing them with antiperistaltic SSSA during @entity3 surgery. MATERIALS AND METHODS: We conducted a randomized controlled trial of @entity0 with @entity3 who underwent elective curative resection and had enough intestinal mobility at @entity1 . The primary outcome was the presence of anastomotic failure, including leakage, @entity2 , and @entity5 . RESULTS: Between July 2012 and January 2014, forty @entity0 were enrolled (20 @entity0 in each group). The study was suspended on detecting excess morbidity in the isoperistaltic SSSA group. No significant differences were observed in all preoperative backgrounds between the two groups. @entity4 was seen in two @entity0 in the isoperistaltic SSSA group, compared with none in the antiperistaltic SSSA group, although the difference was not statistically significant (P  =  0.487). One @entity0 in the antiperistaltic SSSA group had @entity5 , which improved conservatively, compared with none in the isoperistaltic SSSA group (P  =  1.000). No @entity2 was seen in either group. There was no significant difference in the median postoperative hospital stay (P  =  0.313). CONCLUSIONS: This study did not show any short-term advantage or disadvantage of isoperistaltic SSSA compared with that of antiperistaltic SSSA. However, considering that @entity4 occurred only in the isoperistaltic SSSA group, additional modifications are recommended to perform safe isoperistaltic SSSA for colon surgery.

title: Isoperistaltic versus antiperistaltic stapled side-to-side XXXX for @entity3 surgery: a randomized controlled trial.

answer: @entity1


abstract: BACKGROUND: Isoperistaltic stapled side-to-side @entity1 (SSSA), which is a modified technique from conventional antiperistaltic SSSA, has the benefits of antiperistaltic SSSA but requires less intestinal mobility. The aim of this randomized controlled trial was to evaluate short-term outcomes of isoperistaltic SSSA comparing them with antiperistaltic SSSA during @entity3 surgery. MATERIALS AND METHODS: We conducted a randomized controlled trial of @entity0 with @entity3 who underwent elective curative resection and had enough intestinal mobility at @entity1 . The primary outcome was the presence of anastomotic failure, including leakage, @entity2 , and @entity5 . RESULTS: Between July 2012 and January 2014, forty @entity0 were enrolled (20 @entity0 in each group). The study was suspended on detecting excess morbidity in the isoperistaltic SSSA group. No significant differences were observed in all preoperative backgrounds between the two groups. @entity4 was seen in two @entity0 in the isoperistaltic SSSA group, compared with none in the antiperistaltic SSSA group, although the difference was not statistically significant (P  =  0.487). One @entity0 in the antiperistaltic SSSA group had @entity5 , which improved conservatively, compared with none in the isoperistaltic SSSA group (P  =  1.000). No @entity2 was seen in either group. There was no significant difference in the median postoperative hospital stay (P  =  0.313). CONCLUSIONS: This study did not show any short-term advantage or disadvantage of isoperistaltic SSSA compared with that of antiperistaltic SSSA. However, considering that @entity4 occurred only in the isoperistaltic SSSA group, additional modifications are recommended to perform safe isoperistaltic SSSA for colon surgery.

title: Isoperistaltic versus antiperistaltic stapled side-to-side @entity1 for XXXX surgery: a randomized controlled trial.

answer: @entity3


abstract: AIM: Being overweight has been associated with the risk of developing @entity2 , but studies have produced conflicting results, for example with regard to possible links to @entity1 . This study aimed to explore the relationship between body mass index (BMI) and school-age @entity2 . METHODS: Data were obtained from a prospective, longitudinal study of 5044 @entity0 born in western Sweden. The parents answered questionnaires at six months and one, four-and-a-half and eight years of age. The response rate to the final questionnaire at the age of eight was just over 80%. BMI was adjusted for age and gender, and a high BMI was defined as the 85th percentile and above. RESULTS: A multivariate analysis showed an independently increased risk of doctor-diagnosed @entity2 among @entity0 with a persistently high BMI, both in infancy and at school age, with an adjusted odds ratio (aOR) of 2.9 and a 95% confidence interval (CI) of 1.3-6.4. In addition, persistently high BMI was associated with an increased risk of @entity3 (aOR 4.7, 95% CI 2.0-11.0). CONCLUSION: A persistently high BMI during childhood increased the risk of doctor-diagnosed @entity2 at school age. The increased risk of @entity3 suggests an effect mediated via the immune system.

title: A persistently high body mass index increases the risk of XXXX at  school age.

answer: @entity3


abstract: BACKGROUND: Risk adjustment models were used to estimate health care consumption after adjusting for individual characteristics or other factors. The results of this technique were not satisfying. One reason could be that the length of time to document consumption might be associated with the mean and variance of observed health care consumption. This study aims to use a simplified mathematical model and real-world data to explore the relationship of observation time (one or two years) and predictability. METHODS: This study used cross-sectional (one-year) and 2-year panel data sets of the @entity0 ( @entity0 ) from 1996 to 2008. Comparisons of the health care consumption (total health expenditure, emergency room (ER) and office-based visits) included ratios of means and @entity1 ( @entity1 ). Risk adjustment models for one- and two-year data used generalized linear model. RESULTS: The ratios of mean health care consumption (two-year to one-year total expenditure, ER and office-based visits) seemed to be two in most age groups and the ratios of @entity1 varied around or above two. The R-squared of two-year models seemed to be slightly better than that of one-year models. CONCLUSIONS: We find health expenditure and ER or office-based visits observed in two consecutive years were about twice those observed in a single year for most age, similar to the ratios predicted in mathematical examples. The ratios of mean spending and visits varied across age groups. The other finding is that the predictability of two-year consumption seems better than that of one-year slightly. The reason is not clear and we will continue studying this phenomenon.

title: Risk adjustment and observation time: comparison between cross-sectional and 2-year panel data from the XXXX ( @entity0 ).

answer: @entity0


abstract: BACKGROUND: Risk adjustment models were used to estimate health care consumption after adjusting for individual characteristics or other factors. The results of this technique were not satisfying. One reason could be that the length of time to document consumption might be associated with the mean and variance of observed health care consumption. This study aims to use a simplified mathematical model and real-world data to explore the relationship of observation time (one or two years) and predictability. METHODS: This study used cross-sectional (one-year) and 2-year panel data sets of the @entity0 ( @entity0 ) from 1996 to 2008. Comparisons of the health care consumption (total health expenditure, emergency room (ER) and office-based visits) included ratios of means and @entity1 ( @entity1 ). Risk adjustment models for one- and two-year data used generalized linear model. RESULTS: The ratios of mean health care consumption (two-year to one-year total expenditure, ER and office-based visits) seemed to be two in most age groups and the ratios of @entity1 varied around or above two. The R-squared of two-year models seemed to be slightly better than that of one-year models. CONCLUSIONS: We find health expenditure and ER or office-based visits observed in two consecutive years were about twice those observed in a single year for most age, similar to the ratios predicted in mathematical examples. The ratios of mean spending and visits varied across age groups. The other finding is that the predictability of two-year consumption seems better than that of one-year slightly. The reason is not clear and we will continue studying this phenomenon.

title: Risk adjustment and observation time: comparison between cross-sectional and 2-year panel data from the @entity0 ( XXXX ).

answer: @entity0


abstract: BACKGROUND: Unaccompanied refugee minors (URMs) have high levels of @entity1 symptoms, and concerns for their access to mental health services have been raised. From the mid-2000s, an increasing number of asylum-seeking URMs, mainly adolescent @entity0 from Afghanistan, have been referred to the @entity0 _ Adolescent Psychiatry emergency unit in Malm  , Sweden. The aim of the study was to compare inpatient @entity1 care between URMs and non-URMs. FINDINGS: All admissions in 2011 at the emergency unit were identified and divided into URMs (n   =   56) and non-URMs (n   =   205). On the basis of unique @entity0 ' first treatment occasion, a group level analysis was performed on gender, age, treatment duration, additional treatment occasions/ @entity0 , involuntary care, involuntary care by gender, and @entity2 -10 principal diagnosis. To retrieve further sample characteristics, a questionnaire was administered to the physicians responsible for admitting @entity0 in 2011. More URMs than non-URMs exhibited self-harm or suicidal behaviour in conjunction with referral. 86% of URMs were admitted with symptoms relating to stress in the asylum process. In the catchment area, 3.40% of the URM population received inpatient care and 0.67% inpatient involuntary care, compared to 0.26% and 0.02% respectively of the non-URM population, both comparisons p   <   0.001. There were more @entity0 in the URM group (95%) compared to the non-URM group (29%). A difference in use of involuntary care disappeared after adjusting for gender. No differences were found in diagnoses except for @entity3 (F40-48), which were more common in the URM group. CONCLUSION: From an epidemiological perspective, URMs were overrepresented in inpatient @entity1 care.

title: Overrepresentation of unaccompanied refugee minors in inpatient XXXX care.

answer: @entity1


abstract: UNASSIGNED: Objective   This study aims to investigate the effects of antenatal @entity1 on intestinal blood flow in preterm neonates. Study Design   In this prospective case-match study, 25 preterm neonates exposed to @entity1 antenatally were included (study group). Overall, 25 gestational age-matched neonates who had no exposure to @entity0 constituted the control group. Serial daily Doppler flow measurements of @entity3 ( @entity3 ) were performed. The time to reach full feeds, first meconium passage were assessed. Presence of feeding intolerance or @entity2 was recorded. Results   Blood flow velocities of @entity3 were not different between the groups during the first five postnatal days. However, @entity3 blood flow showed an increasing trend in the control group unlike the study group (control group, p   <   0.001; study group, p   =   0.29). There was no significant difference between the two groups regarding the time to reach full feeds or first meconium passage and presence of feeding intolerance. No case of @entity2 was seen. Conclusion   Antenatal @entity0 does not significantly affect intestinal blood flow, but it seems to attenuate the increasing trend of the intestinal blood flow in the early postnatal days. However, this study failed to show any impact of this finding on clinical outcomes.

title: Effects of Antenatal XXXX Exposure on Intestinal Blood Flow and Outcome in Preterm Neonates.

answer: @entity0


abstract: BACKGROUND: @entity3 ( @entity3 ) are encouraged to get vaccinated during @entity2 pandemics to reduce their own, and @entity0 ', risk of @entity1 , and to encourage their @entity0 to get immunised. Despite extensive research on @entity3 ' receipt of vaccination, little is known about how @entity3 articulate pandemic @entity2 vaccination advice to @entity0 . AIMS: To explore @entity3 ' uptake of the A/H1N1 vaccine during the pandemic of 2009-2010, their recommendations to @entity0 at the time, and their anticipated choices around @entity2 vaccination under different pandemic scenarios. METHOD: We conducted semi-structured interviews and focus groups with eight vaccinated and seventeen non-vaccinated @entity3 from primary care practices in England. The data was analysed using thematic analysis. RESULTS: The @entity3 constructed their receipt of vaccination as a personal choice informed by personal health history and perceptions of vaccine safety, while they viewed @entity0 ' vaccination as choices made following informed consent and medical guidelines. Some @entity3 received the A/H1N1 vaccine under the influence of their local practice organizational norms and values. While non-vaccinated @entity3 regarded @entity0 ' vaccination as @entity0 ' choice, some vaccinated @entity3 saw it also as a public health issue. The non-vaccinated @entity3 emphasised that they would not allow their personal choices to influence the advice they gave to @entity0 , whereas some vaccinated @entity3 believed that by getting vaccinated themselves they could provide a reassuring example to @entity0 , particularly those who have concerns about @entity2 vaccination. All @entity3 indicated they would accept vaccination under the severe pandemic scenario. However, most non-vaccinated @entity3 expressed reticence to vaccinate under the mild pandemic scenario. CONCLUSIONS: Providing evidence-based arguments about the safety of new vaccines and the priority of public health over personal choice, and creating strong social norms for @entity2 vaccination as part of the organizational culture, should increase uptake of @entity2 vaccination among primary care @entity3 and their @entity0 .

title: Accounting for personal and professional choices for pandemic XXXX vaccination amongst English healthcare workers.

answer: @entity2


abstract: BACKGROUND: Duodenal diverted sleeve gastrectomy with ileal interposition (DDSG-II) is a bariatric-metabolic operation designed to treat @entity1 ( @entity1 ). It is restrictive (SG) but also acts on the small bowel with functional effects. The objective of the present study was to investigate whether or not it is also a malabsorptive operation. METHODS: Twelve @entity2 @entity0 (9 female and 3 male) affected by @entity1 had DDSG-II. Follow-up was every 3 months, and the results after 1 year are reported here. Clinical conditions, related to @entity1 and @entity5 , changes in weight, body mass index, fasting glucose plasma levels, HbA1c (glycated hemoglobin %), basal insulin, vitamin B12, folic acid, vitamin D, total proteins, albumin, and hemoglobin were recorded. Basal plasma levels of @entity7 (pg/mL) and of 7a-hydroxy-4-cholesten-3-one (C4) ( g/dL) were also determined for the diagnosis of @entity4 . The results were expressed as mean  SEM, and the differences between times compared by the Mann Whitney U test; P<.05 was considered significant. RESULTS: After 1 year, all @entity0 had a significant @entity3 (-33.2  3 kg) with @entity1 remission according to the American @entity1 Association criteria (11), criteria. No significant changes in total proteins, albumin, hemoglobin, and vitamins (B6, B12, and D) were detected. C4 did not change after the operation (2  .5   g/dL versus 1.6  .5   g/dL), whereas @entity7 significantly increased (from 85  11.2 pg/mL to 166.4  28.2 pg/mL, P<.04). Only 2 @entity0 had mild symptoms of @entity6 . CONCLUSIONS: DDSG-II is effective for treatment of @entity1 @entity0 , increases the enterokine @entity7 , and does not cause @entity4 .

title: Duodenal diverted sleeve gastrectomy with ileal interposition does not cause XXXX .

answer: @entity4


abstract: BACKGROUND: Since the arrival of the universal definition of @entity1 more sensitive troponin assays have been developed. How these occurrences have influenced the proportions and clinical features of the components of @entity3 have not been studied prospectively in unselected hospital @entity0 . METHODS: During 2010 we evaluated all @entity0 in whom cardiac troponin I had been measured at a single university hospital. The diagnosis of @entity1 ( @entity1 [ @entity1 ] or @entity1 [ @entity1 ]) was established in cases of a rise and/or fall of cardiac troponin I together with cardiac ischemic features. @entity0 with unstable chest discomfort and cardiac troponin I values below the decision limit of @entity1 were diagnosed as having @entity4 . The definition of @entity3 included @entity4 , @entity1 , and @entity1 . Mortality data were obtained from the Danish Civil Personal Registration System. RESULTS: Of 3762 consecutive @entity0 , 516 had @entity3 . Unstable @entity2 was present in 7%, @entity1 in 67%, and @entity1 in 26%. The @entity1 @entity0 were older, more frequently @entity0 , and had more comorbidities than @entity0 with @entity4 and @entity1 . At median follow-up of 3.2 years 195 @entity0 had died: 14% of @entity4 , 45% of @entity1 , and 25% of @entity1 @entity0 . Age-adjusted log-rank statistics revealed differences in mortality: @entity1 vs @entity4 (P  = .0091) and @entity1 vs @entity1 (P  = .0045). CONCLUSIONS: The application of the universal definition together with the use of a contemporary troponin assay seems to have reduced the proportion of @entity0 with @entity4 to the benefit of @entity0 with @entity1 . Despite this, @entity1 @entity0 have a sustained higher mortality than @entity0 with @entity1 .

title: Diagnosis of XXXX has declined markedly with the advent of more sensitive troponin assays.

answer: @entity4


abstract: OBJECTIVES: @entity2 in teeth (accentuated lines and @entity3 ) have played a critical role in studies of childhood disease, nutrition, weaning, environmental variation, and early mortality. While these enigmatic structures have been lauded for their potential insights into @entity0 evolution, few studies have examined defects in individuals of known histories. MATERIALS AND METHODS: Here we document defects in the molars of three wild juvenile @entity5 from the Ta   forest ( @entity5 verus) and compare them with behavioral, epidemiological, and environmental records. RESULTS: Accentuated lines of differing intensities were found throughout molar crown and root growth, and were most common in a juvenile who demonstrated slow skeletal growth and prolonged maternal @entity4 . These defects were observed in association with some but not all injuries and disease outbreaks in this community. A 10-year record of accentuated line frequency across individuals shows a significant negative correlation with rainfall, but does not correlate with fruit availability or reveal significant annual trends. Several @entity3 formed between    0.6 and 5.8 years of age on molar crowns and roots of the three individuals, however, available behavioral and epidemiological records do not explain their causation. DISCUSSION: While teeth may provide precise and accurate records of illness and @entity1 in some cases, inferring seasonal cycles, social stress, or weaning in living or fossil primate dentitions requires additional evidence beyond the presence, absence, or degree of expression of these defects. Studies that microsample bulk and trace elements may provide a more secure context for the interpretation of environmental, physiological, and dietary changes that impact dental tissue formation. Am J Phys Anthropol, 2015.    2015 Wiley Periodicals, Inc.

title: @entity2 in the teeth of three wild XXXX from the Ta   forest.

answer: @entity5


abstract: OBJECTIVES: @entity2 in teeth (accentuated lines and @entity3 ) have played a critical role in studies of childhood disease, nutrition, weaning, environmental variation, and early mortality. While these enigmatic structures have been lauded for their potential insights into @entity0 evolution, few studies have examined defects in individuals of known histories. MATERIALS AND METHODS: Here we document defects in the molars of three wild juvenile @entity5 from the Ta   forest ( @entity5 verus) and compare them with behavioral, epidemiological, and environmental records. RESULTS: Accentuated lines of differing intensities were found throughout molar crown and root growth, and were most common in a juvenile who demonstrated slow skeletal growth and prolonged maternal @entity4 . These defects were observed in association with some but not all injuries and disease outbreaks in this community. A 10-year record of accentuated line frequency across individuals shows a significant negative correlation with rainfall, but does not correlate with fruit availability or reveal significant annual trends. Several @entity3 formed between    0.6 and 5.8 years of age on molar crowns and roots of the three individuals, however, available behavioral and epidemiological records do not explain their causation. DISCUSSION: While teeth may provide precise and accurate records of illness and @entity1 in some cases, inferring seasonal cycles, social stress, or weaning in living or fossil primate dentitions requires additional evidence beyond the presence, absence, or degree of expression of these defects. Studies that microsample bulk and trace elements may provide a more secure context for the interpretation of environmental, physiological, and dietary changes that impact dental tissue formation. Am J Phys Anthropol, 2015.    2015 Wiley Periodicals, Inc.

title: XXXX in the teeth of three wild @entity5 from the Ta   forest.

answer: @entity2