abstract: OBJECTIVE: Pelvic and paraortic lymph nodal regions are frequent sites of relapse in @entity0 with @entity3 who have not undergone adjuvant external beam radiation. We investigated outcomes after definitive management of nodal relapses of @entity3 with intensity modulated radiation therapy (IMRT). METHODS: Between 2002-2012, 38 @entity0 with @entity3 who had no prior external beam radiation were treated definitively using IMRT for regionally confined pelvic or paraortic nodal recurrences. Thirteen (34%) had chemotherapy prior to radiation, and 21 (55%) received concurrent chemotherapy. The nodal basins were typically treated to 45-50Gy, with a boost to the gross @entity1 to a median total of 64.7Gy (range 59-73Gy). RESULTS: The median overall survival from date of recurrence was 46.1months and the 2-year survival was 71%. @entity0 who received concurrent chemotherapy had a significantly longer median survival (61.9months versus 28.7months, p=0.034). In-field failures were more frequent in @entity0 who received chemotherapy prior to radiation, had a shorter recurrence-free interval, received a lower radiation dose, and had higher @entity1 grade. Three @entity0 (8%) experienced grade 3-4 late gastrointestinal (GI) @entity2 . CONCLUSIONS: Long-term survival can be achieved in @entity0 with nodal recurrences of @entity3 . The use of concurrent chemotherapy and dose escalation with IMRT as feasible may improve survival for @entity0 with isolated nodal recurrences of @entity3 .

title: Management of nodal recurrences of XXXX with IMRT.

answer: @entity3


abstract: BACKGROUND: Pathological studies have suggested that @entity6 ( @entity6 ) may be caused by culprit lesions with intact fibrous cap (IFC), including @entity7 . This study sought to evaluate the morphological features and clinical outcomes of @entity0 with @entity6 caused by lesions with IFC. METHODS: A total of 318 @entity0 with @entity6 who underwent optical coherence tomography (OCT) of a culprit lesion were investigated. The culprit lesions were categorized as follows: those with @entity2 (PR group), those with an IFC (IFC group), and those with a massive @entity5 precluding plaque visualization (MT group). Intravascular ultrasound (IVUS) was performed in 297 @entity0 . Clinical follow-up data were collected regarding adverse @entity1 , including death, @entity3 , revascularization, and @entity4 requiring hospitalization. RESULTS: Culprit lesions were categorized into 141 RPs, 131 IFCs, and 46 MTs. IFC group exhibited a smaller remodeling index and less frequently attenuated plaques on IVUS. Three hundred and seven @entity0 (96.5%) were followed for a median follow-up duration of 576days. Adverse @entity1 were observed in 93 @entity0 (30.3%). Kaplan-Meier analysis demonstrated a significantly lower event rate in IFC group compared with the @entity8 and MT groups. Cox proportional hazard analysis demonstrated that an IFC and multivessel disease were independent predictors of adverse events [hazard ratio 0.57, 95% confidence interval (CI) 0.33-0.98, p=0.043 and hazard ratio 1.72, 95% CI 1.09-2.73, p=0.021]. CONCLUSIONS: Culprit lesions with IFC showed smaller remodeling indices by IVUS, and were associated with better long-term prognosis compared with those with @entity2 .

title: Plaque morphologies and the clinical prognosis of XXXX caused by lesions with intact fibrous cap diagnosed by optical coherence tomography.

answer: @entity6


abstract: BACKGROUND: Greater body mass index (BMI), a measure of overall adiposity, is associated with a higher risk of @entity0 . The role of central adiposity, often measured by waist circumference, is less well understood, especially among premenopausal @entity1 . The objective of the current study was to examine multiple measures of adiposity in relation to @entity0 in a prospective cohort study. METHODS: A total of 50,884 Sister Study cohort @entity1 aged 35 to 74 years were enrolled from 2003 through 2009. Inclusion criteria for the cohort included having a sister previously diagnosed with @entity0 . Trained study personnel measured height, weight, and waist and hip circumference during a home visit and study @entity1 completed a detailed questionnaire. Using Cox regression analysis, we estimated multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) for @entity0 risk associated with adiposity measurements, considering @entity2 subtype and menopausal status. RESULTS: In total, 2009 @entity0 were diagnosed during follow-up (mean   =   5.4 years). Weight, BMI, waist circumference, and waist-to-hip ratio were found to be positively associated with overall @entity0 risk and HRs were greater among postmenopausal @entity1 , those with hormonally responsive @entity2 , and @entity1 who were not currently using postmenopausal hormones. In models that adjusted for BMI, waist circumference associations persisted among both postmenopausal @entity1 (81-88 cm vs  <=80 cm: HR   =   1.16 [95% CI 1.01-1.35] and >88 cm vs  <=80 cm: HR   =   1.30 [95% CI 1.10-1.54]) and premenopausal @entity1 (81-88 cm vs  <=80 cm: HR   =   1.56 [95% CI 1.19-2.04] and >88 cm vs  <=80 cm: HR   =   1.30 [95% CI 0.91-1.87]). CONCLUSIONS: Findings from this large, prospective study with examiner-measured body size indicate that waist circumference is independently and positively associated with both premenopausal and @entity0 risk. @entity2 2015;121:3700-3708.    2015 American @entity2 Society.

title: Overall and central adiposity and XXXX risk in the sister study.

answer: @entity0


abstract: UNASSIGNED: @entity2 -immobilized magnetic @entity3 (mPHEMAH) nanoparticles were prepared by surfactant-free emulsion polymerization for cytochrome C (cyt C) purification from @entity0 liver. Elemental analysis, atomic force microscopy, zeta sizer, and vibrating sample magnetometer were used to characterize mPHEMAH nanoparticles. In addition to these characterization steps, surface area, average particle size, and size distribution of mPHEMAH nanoparticles were determined. Quantity of immobilized @entity2 was measured using atomic absorption spectrophotometry. @entity4 and @entity2 content of mPHEMAH nanoparticles were 0.18 mmol/g polymer and 0.11 mmol/g polymer, respectively. Specific surface area of @entity2 -immobilized mPHEMAH nanoparticles was 1180 m(2) /g. Effect of initial cyt C concentration, pH, temperature, and ionic strength on cyt C adsorption onto @entity2 -immobilized mPHEMAH nanoparticles was investigated. Maximum cyt C adsorption capacity of @entity2 -immobilized mPHEMAH nanoparticles was 311.9 mg/g polymer. Maximum adsorption was obtained at pH 8.0 and 4    C. @entity2 -immobilized mPHEMAH nanoparticles were used ten times with 4.1% decrease in adsorption capacity. In the last stage, @entity2 -immobilized mPHEMAH nanoparticles were used to purify cyt C from @entity0 liver tissue, and the purity of desorbed fractions was controlled by @entity1 -PAGE.

title: Metal-immobilized magnetic nanoparticles for cytochrome C purification from XXXX liver.

answer: @entity0


abstract: BACKGROUND: Lung contusion (LC) followed by @entity1 ( @entity1 ) causes persistent bone marrow (BM) dysfunction lasting up to 7 d after injury. Mesenchymal stem cells (MSCs) are multipotent cells that can hasten healing and exert protective immunomodulatory effects. We hypothesize that MSCs can attenuate BM dysfunction after combined LCHS. MATERIALS AND METHODS: Male @entity0 (n = 5-6 per group) underwent LC plus 45 min of @entity1 (mean arterial pressure of 30-35). Allogeneic MSCs (5 * 10(6) cells) were injected intravenously after resuscitation. At 7 d, BM was analyzed for cellularity and growth of hematopoietic progenitor cell (HPC) colonies (colony-forming unit-erythroid; burst-forming unit-erythroid; and colony-forming unit-granulocyte, erythrocyte, monocyte, megakaryocyte). Flow cytometry measured %HPCs in peripheral blood; plasma @entity2 ( @entity2 ) levels were measured via enzyme-linked immunosorbent assay. Data were analyzed by one-way analysis of variance followed by the Tukey multiple comparison test. RESULTS: As previously shown, at 7 d, LCHS resulted in 22%, 30%, and 24% decreases in colony-forming unit-granulocyte, erythrocyte, monocyte, megakaryocyte, burst-forming unit-erythroid, and colony-forming unit-erythroid colony growth, respectively, versus naive. Treatment with MSCs returned all BM parameters to naive levels. There was no difference in %HPCs in peripheral blood between groups; however, @entity2 remained increased up to 7 d after LCHS. MSCs returned @entity2 to naive levels. Plasma from animals receiving MSCs was not suppressive to the BM. CONCLUSIONS: One week after injury, the persistent BM dysfunction observed in animals undergoing LCHS is reversed by treatment with MSCs with an associated return of plasma @entity2 levels to normal. Plasma from animals undergoing LCHS plus MSCs was not suppressive to BM cells in vitro. Treatment with MSCs after injury and shock reverses BM suppression and returns plasma @entity2 levels to normal.

title: Mesenchymal stem cells reverse trauma and XXXX -induced bone marrow dysfunction.

answer: @entity1


abstract: UNASSIGNED: The focus of this research is in the definition of programmable expert Personal Health Systems (PHS) to monitor @entity0 affected by @entity2 using agent oriented programming and mobile computing to represent the interactions happening amongst the components of the system. The paper also discusses issues of knowledge representation within the medical domain when dealing with temporal patterns concerning the physiological values of the @entity0 . In the presented agent based PHS the doctors can personalize for each @entity0 monitoring rules that can be defined in a graphical way. Furthermore, to achieve better scalability, the computations for monitoring the @entity0 are distributed among their devices rather than being performed in a centralized server. The system is evaluated using data of 21 @entity1 @entity0 to detect temporal patterns according to a set of monitoring rules defined. The system's scalability is evaluated by comparing it with a centralized approach. The evaluation concerning the detection of temporal patterns highlights the system's ability to monitor chronic @entity0 affected by @entity1 . Regarding the scalability, the results show the fact that an approach exploiting the use of mobile computing is more scalable than a centralized approach. Therefore, more likely to satisfy the needs of next generation PHSs. PHSs are becoming an adopted technology to deal with the surge of @entity0 affected by @entity2 . This paper discusses architectural choices to make an agent based PHS more scalable by using a distributed mobile computing approach. It also discusses how to model the medical knowledge in the PHS in such a way that it is modifiable at run time. The evaluation highlights the necessity of distributing the reasoning to the mobile part of the system and that modifiable rules are able to deal with the change in lifestyle of the @entity0 affected by @entity2 .

title: Processing XXXX Composite Events in MAGPIE.

answer: @entity1


abstract: OBJECTIVE: To evaluate the trans and @entity2 and surgical results of Tension Free Vaginal Tape Obturator System (TVT-O) for stress @entity3 treatment in Angeles del Pedregal Hospital in a five year follow-up. MATERIAL AND METHODS: A retrospective, descriptive case series study with 67 @entity0 was conducted in the Urogynecology Clinic in Hospital Angeles del Pedregal between January 2006 and December 2012. @entity0 with stress @entity3 treated by TVT-O were included. Complications and efficacy of the treatment are described in a 5 year follow-up. RESULTS: 29.9% of the @entity0 had the urodynamic diagnosis of @entity4 . The 55.2% of them had no other procedure done than the TVT-O. No transoperative complications were observed, but in the postoperative period, 2 (3.%) @entity0 had urinary retention secondary to overcorrected urethra and 1 (1.5%) with intense groin @entity1 . Two cases (3%) presented tape erosion to vagina at 18 months follow-up, with less than 5mm exposure areas. Average follow-up time was 2 years. 46.26% of @entity0 completed a 5 years follow-up. Subjective and objective cures were obtained in all 67 @entity0 . CONCLUSIONS: Tension free @entity5 is a minimally invasive procedure that has excellent results (above 95%) in the treatment of stress @entity3 with a low rate of complications. Currently, it can be considered as the gold standard surgical treatment for stress @entity3 .

title: [Stress XXXX treatment with modified technique tension-free vaginal tape obturator].

answer: @entity3


abstract: INTRODUCTION: Caloric restriction is the only well-documented nutritional intervention prolonging the life of mammals. This method modifies the lipid levels in blood, controlling @entity1 and delaying the onset of many medical conditions associated with @entity3 . The aim of the study was to carry out a comparative analysis of lipid profile in @entity0 on Mediterranean or CRON (Caloric Restriction with Optimal Nutrition) diets, before and after six weeks of dieting. MATERIAL AND METHODS: The following parameters were compared: total @entity2 , total lipids, @entity4 , LDL @entity2 , HDL @entity2 , and BMI. Additionally, we measured the levels of insulin, HOMA score, and anthropometric parameters. The comparative analysis demonstrated a statistically significant correlation between mild caloric restriction and blood lipid profile. Results from studies on @entity0 who underwent six-week dietetic intervention indicated statistically significant changes in biochemical parameters due to caloric restrictions. Such changes were not found in subjects following the Mediterranean diet. The greatest decrease in the blood level of @entity4 was found in subjects on the CRON diet, LDL @entity2 , total @entity2 and total lipid levels also decreased. No significant changes if biochemical parameters were found in @entity0 on the Mediterranean diet. CONCLUSIONS: A comparative analysis of all parameters demonstrated that the use of mild caloric restrictions with ensured supply of all necessary nutrients seems to be the most effective solution for reducing fatty tissue.

title: [CHANGES IN BODY MASS AND BLOOD LIPID LEVELS IN XXXX UNDERGOING CALORIC RESTRICTION].

answer: @entity0


abstract: UNASSIGNED: Objective. To evaluate efficacy and safety of injectable extended-release naltrexone (XR-NTX, Vivitrol), an opioid receptor antagonist, in the treatment of @entity1 , we carried out a 1-year open-label extension study. Material and methods. The study followed the initial 6-month randomized, double-blind, PBO-controlled investigation of XR-NTX, used in dose 380 mg, as a treatment for @entity1 . The study was conducted at 13 clinical sites in Russia. The main measurements were monthly urine samples (efficacy) and adverse events (safety). Results and   onclusion. The open-label extension included 114 @entity0 (67 continued on XR-NTX and 47 switched from placebo). Overall, 62.3% (95% CI: 52.7%, 71.2%) of @entity0 completed the extension. Urine testing revealed that 50.9% (41.5%, 60.4%) were abstinent from opioids at all assessments during the 1-year open-label phase. Adverse events were reported by 21.1% of @entity0 . Elevations in liver function tests occurred in 16.7% of @entity0 . No severe adverse events were reported. The data obtained demonstrate the long-term safety and efficacy of XR-NTX in opioid dependent @entity0 .

title: [Injectable extended-release naltrexone for XXXX : an open label study of long-term safety and efficacy.]

answer: @entity1


abstract: UNASSIGNED: Objective. To analyze @entity1 aggravation associated with antiepileptic drugs (AED) in adult @entity0 . Material and methods. We examined 1407 @entity0 aged 18-89 years. Different patterns of @entity2 aggravation were identified in 103 @entity0 . Results. Aggravated @entity2 due the generic substitution were found in 32 @entity0 . First was topiramate (TPM) (n=12), followed by valproates (VPA) (n=8), carbamazepine (CBZ) (n=5), lamotrigine (LTG) (n=1) and levetiracetam (LEV) (n=1). @entity0 with @entity6 ( @entity6 ) suffered aggravation with CBZ in 17 cases, VPA - in 6, TPM - in 6, LTG - in 1 and LEV - in 1. CBZ aggravated absences in @entity0 with @entity4 ( @entity4 ) were found in 5 cases of 17 (29.4%), with @entity4 ( @entity4 ) - in 1 of 24 (4.2%), absences and @entity3 in @entity5 ( @entity5 ) - in 9 of 47 (19.1%), absences with eyelid @entity3 (Jeavons syndrome) - in 2 of 11 (18.2%). @entity2 aggravations with different AEDs were observed in 13 @entity0 . This pattern of aggravation was associated with resistant @entity1 and poor prognosis. @entity2 aggravation due to increasing the dose of AEDs was found in 10 cases and associated with resistant @entity1 and poor outcome. "True" aggravation was associated with CBZ in 34 @entity0 , including 16 @entity6 @entity0 , with TPM - in 13, VPA - 5, LTG - 5, LEV - 2 and with clonazepam in 1 @entity0 . Most often @entity2 aggravation was associated with CBZ in @entity6 @entity0 (8.3%), and with LTG, TPM and CBZ in @entity0 with other @entity1 (non @entity6 ): 4.9%, 4% and 3.7%, respectively. Conclusions. Different AEDs can cause aggravation. @entity2 aggravation after generic substitution was characteristic of TPM most frequently. @entity2 aggravation with different AEDs and due to increasing the dose of AEDs was associated with poor outcome. In all cases, @entity2 aggravation was more frequently caused by LTG (4.7%), CBZ (3.7%) and TPM (3.3%). To reduce the risk of aggravation, slow AEDs titration and keeping a diary of @entity2 are required.

title: [Antiepileptic drugs and XXXX aggravation.]

answer: @entity2


abstract: BACKGROUND: The onset of winter of 2014-2015 saw an alarming spurt in @entity4 A (H1N1) pdm 09 leading to a significant mortality. Rajasthan was one of the foremost affected state bearing the frontal attack in which majority of @entity2 occurred early and in the young. OBJECTIVE: To sketch out the mortality profile with respect to demographic and clinical progression with an aim to identify the groups, this virus conspicuously picked up with a perspective to control some of the avoidable factors. METHODS: We analyzed the epidemiological data in 76 RT-PCR confirmed @entity2 of H1N1 @entity0 that occurred between 1st January 2015 and 28 February 2015 over a period of 59 days at SMS Medical College Hospital, Jaipur. RESULTS: A total of 412 @entity0 got hospitalized during two months period from 1st January 2015 to 28th February 2015, out of which 76 fatal cases presenting with category C symptoms along with radiological evidence of @entity1 were analyzed. 48.6% @entity2 occurred in the 18-40 years of age group. The mean age being 44.01    15.07 years. Females had a marginally increased mortality rate (F: M-1.23:1). The mean time of onset of symptoms to hospitalization was 6.79    4.63 days. Fifty-one (67.1% 0) @entity0 were from urban areas, whereas 25 (32.89%) belonged to rural areas. Only 7.83% @entity0 presented within 24 - 48 hours whereas 46% presented within 5 days of onset of symptoms. 66.9% succumbed within 5 days of hospitalization, despite of starting @entity5 in a dose of 150 mg/bd on the day of admission. 64.5% had predisposing risk factors. @entity1 was observed in all the 76 @entity0 , @entity3 in 21.12%, @entity6 in 30.26% and AKI in 9.21%. CONCLUSIONS: The in-hospital mortality of 17.79% despite of starting @entity5 has raised concern about identifying the so called "Rapid Progressors" [66.9% succumbing within 5 days of hospitalization]. As a corollary of this analysis the authors are of the opinion that a rejig of the existing guidelines to identify and treat @entity4 like illness be made available at the national level. What factors promote rapid progression especially in a group without any predisposing risk condition should form the focus of future studies. As risk group individuals formed a major chunk of @entity2 , the need to vaccinate this group should form a scaffold on which future directions and interventions have to be built up to combat the morbidity and mortality.

title: Profiling the Mortality due to XXXX (H1N1) pdm09 at a Tertiary Care Hospital in Jaipur during the Current Season--January _ February 2015.

answer: @entity4


abstract: @entity7 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity0 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity4 cells growth, migration, and the mechanisms underlying the anti- @entity0 activities of GA. @entity2 test was used to detect the effect of GA on TF-1 @entity4 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity3 and @entity5 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity6 phosphorylation in vitro. We also evaluated the anti- @entity0 effect of GA in TF-1 @entity0 bearing BALB/c @entity1 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity0 growth in vivo and down-regulated @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 @entity0 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity4 that targets the @entity3 / @entity5 / @entity6 pathway.

title: XXXX inhibits @entity4 cell growth and migration via blocking @entity3 / @entity5 / @entity6 signaling.

answer: @entity7


abstract: @entity7 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity0 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity4 cells growth, migration, and the mechanisms underlying the anti- @entity0 activities of GA. @entity2 test was used to detect the effect of GA on TF-1 @entity4 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity3 and @entity5 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity6 phosphorylation in vitro. We also evaluated the anti- @entity0 effect of GA in TF-1 @entity0 bearing BALB/c @entity1 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity0 growth in vivo and down-regulated @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 @entity0 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity4 that targets the @entity3 / @entity5 / @entity6 pathway.

title: @entity7 inhibits @entity4 cell growth and migration via blocking @entity3 / @entity5 / XXXX signaling.

answer: @entity6


abstract: @entity7 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity0 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity4 cells growth, migration, and the mechanisms underlying the anti- @entity0 activities of GA. @entity2 test was used to detect the effect of GA on TF-1 @entity4 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity3 and @entity5 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity6 phosphorylation in vitro. We also evaluated the anti- @entity0 effect of GA in TF-1 @entity0 bearing BALB/c @entity1 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity0 growth in vivo and down-regulated @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 @entity0 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity4 that targets the @entity3 / @entity5 / @entity6 pathway.

title: @entity7 inhibits @entity4 cell growth and migration via blocking @entity3 / XXXX / @entity6 signaling.

answer: @entity5


abstract: @entity7 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity0 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity4 cells growth, migration, and the mechanisms underlying the anti- @entity0 activities of GA. @entity2 test was used to detect the effect of GA on TF-1 @entity4 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity3 and @entity5 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity6 phosphorylation in vitro. We also evaluated the anti- @entity0 effect of GA in TF-1 @entity0 bearing BALB/c @entity1 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity0 growth in vivo and down-regulated @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 @entity0 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity4 that targets the @entity3 / @entity5 / @entity6 pathway.

title: @entity7 inhibits XXXX cell growth and migration via blocking @entity3 / @entity5 / @entity6 signaling.

answer: @entity4


abstract: @entity7 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity0 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity4 cells growth, migration, and the mechanisms underlying the anti- @entity0 activities of GA. @entity2 test was used to detect the effect of GA on TF-1 @entity4 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity3 and @entity5 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity6 phosphorylation in vitro. We also evaluated the anti- @entity0 effect of GA in TF-1 @entity0 bearing BALB/c @entity1 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity0 growth in vivo and down-regulated @entity3 , @entity5 , and @entity6 phosphorylation in TF-1 @entity0 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity4 that targets the @entity3 / @entity5 / @entity6 pathway.

title: @entity7 inhibits @entity4 cell growth and migration via blocking XXXX / @entity5 / @entity6 signaling.

answer: @entity3


abstract: Endometriosis involving intestinal mucosa is relatively uncommon. It poses a diagnostic challenge for clinicians and pathologists. We herein report a case of colonoscopic specimen revealing @entity1 . A 39-year-old @entity0 complained of red @entity6 and intermittent @entity5 . Colonoscopic examination showed a rectal mass with @entity7 and circum wall involvement. Biopsy was processed in the suspicious of @entity3 . Morphologically, irregular glands replaced residual colorectal ones, displayed mucin depletion, nuclear stratification and subtile subnuclear vacuoles. The stroma was full of spindle cells with abundant pink cytoplasm and unclear boundary. Due to subjectively interpreting as @entity11 in desmoplastic setting, primary @entity4 was firstly raised. Immunohistochemically, @entity10 , ER and @entity9 identified the essence of ectopic endometrium. @entity8 and @entity12 highlighted residual glands. In case of misdiagnosis, any pathologists should be aware of intestinal @entity2 for each female's colorectal biopsy, especially for that morphology not typical for primary @entity4 or @entity2 . Reading slides carefully combined with a panel of immunomarkers would solve the pitfall.

title: XXXX primarily misinterpreted as @entity4 : a case report and review of literature.

answer: @entity1


abstract: Endometriosis involving intestinal mucosa is relatively uncommon. It poses a diagnostic challenge for clinicians and pathologists. We herein report a case of colonoscopic specimen revealing @entity1 . A 39-year-old @entity0 complained of red @entity6 and intermittent @entity5 . Colonoscopic examination showed a rectal mass with @entity7 and circum wall involvement. Biopsy was processed in the suspicious of @entity3 . Morphologically, irregular glands replaced residual colorectal ones, displayed mucin depletion, nuclear stratification and subtile subnuclear vacuoles. The stroma was full of spindle cells with abundant pink cytoplasm and unclear boundary. Due to subjectively interpreting as @entity11 in desmoplastic setting, primary @entity4 was firstly raised. Immunohistochemically, @entity10 , ER and @entity9 identified the essence of ectopic endometrium. @entity8 and @entity12 highlighted residual glands. In case of misdiagnosis, any pathologists should be aware of intestinal @entity2 for each female's colorectal biopsy, especially for that morphology not typical for primary @entity4 or @entity2 . Reading slides carefully combined with a panel of immunomarkers would solve the pitfall.

title: @entity1 primarily misinterpreted as XXXX : a case report and review of literature.

answer: @entity4


abstract: Management of three @entity0 with necrotizing @entity2 resulting in tracheal dissolution was reviewed with respect to presentation, cause, and management. Loss of tracheal substance led to difficulty in ventilation because of a large air leak. The stomal area cavitated in two @entity0 , denuding the right common carotid artery in one. Purulent peristomal drainage was present in all three @entity0 . Common factors of possible etiologic significance included necrotizing polymicrobial gram-negative @entity2 caused by Pseudomonas, Enterobacter, and @entity3 species. Also of possible importance were suture fixation of the appliance, history of @entity1 , and closure of the incision. Immediate therapy consisted of oral intubation for ventilatory purposes and a regimen of hourly application of 1% @entity4 dressings. Seven to 21 days were necessary to allow formation of sufficient granulation tissue to support replacement of the tracheostomy appliance for continued mechanical ventilation. Once spontaneous ventilation was possible, a Montgomery T-tube was inserted for long-term tracheal stenting prior to reconstruction. The two @entity0 treated by tracheal stenting are long-term survivors. Avoidance of suture fixation of the appliance, aggressive treatment of @entity2 , and adequate stomal toilet may help to avoid this devastating complication.

title: Management of necrotizing XXXX .

answer: @entity2


abstract: UNASSIGNED: Background. Chemotherapy and targeted drugs are important tools in the treatment of @entity2 . A number of the planned treatments are cancelled late which is a great challenge for the clinic to minimize in order to prevent the risk for misused resources. The aim of this study was to analyze the frequency and reasons for late (<48 hours) cancellations and also to get an overview of all intravenous medical anti- @entity2 treatment at the clinic. Material and methods. During four weeks in October 2010 all @entity1 with intravenously administered chemotherapy and/or targeted drugs were registered at the Department of Oncology, Karolinska University Hospital. The survey comprehends the vast majority of all such treatment for solid @entity2 in adult @entity1 in the Stockholm region with two million inhabitants. All @entity5 including their reasons were recorded. Diagnoses, treatment indication, line of treatment and survival, in particular short term survival, were analyzed. Results. Almost 3000 bookings for 1460 @entity1 were included and 13% were cancelled late. @entity1 detoriation was the dominating cause for late cancellation in @entity1 with palliative treatment (59%), while hematological @entity4 was most common in the adjuvant group (42%). The most common treatment indication was palliative (62%). Of the palliative treatments, 95% where given in the first to third treatment line. @entity0 (31.9%) and @entity3 (29.9%) were the two most common diagnoses. Seventy-one @entity1 (4.9%) died within two months after the treatment. Conclusion. A more careful selection and monitoring of the @entity1 might reduce the number of late cancellations due to @entity1 detoriation. To record performance status (PS) as a routine for all @entity1 might be helpful in that process. If the number of late cancellations could be reduced, resources at the clinic could be used more efficiently.

title: Why is intravenous chemotherapy cancelled and how often. Could it be prevented? A prospective analysis of all planned and given intravenous anti- XXXX treatments at the Department of Oncology, Karolinska University Hospital, Stockholm during one month.

answer: @entity2


abstract: OBJECTIVES: Situational analysis of @entity1 ( @entity1 ) morbidity and its management in Ahanta West, Ghana, to identify potential barrier to health care for @entity1 @entity0 . METHODS: Lymphoedema and hydrocoele @entity0 were identified by community health workers from a subset of villages, and were interviewed and participated in focus group discussions to determine their attitudes and practices towards managing their morbidity, and their perceived barriers to accessing care. Local health professionals were also interviewed to obtain their views on the availability of morbidity management services in the district. RESULTS: 62 @entity0 (34 lymphoedema and 28 hydrocoeles) and 13 local health professionals were included in the study. Lymphoedema @entity0 predominantly self-managed their conditions, which included washing with soap and water (61.8%), and exercising the affected area (52.9%). Almost 65% of @entity0 had sought medical assistance at some stage, but support was generally limited to receiving tablets (91%). Local health professionals reported rarely seeing lymphoedema @entity0 , citing stigma and lack of provisions to assist @entity0 as a reason for this. Almost half of hydrocoele @entity0 (44%) chose not to seek medical assistance despite the negative impact it had on their lives. Whilst surgery itself is free with national health insurance, 63% those who had not sought treatment stated that indirect costs of surgery (travel costs, loss of earnings etc) were the most prohibitive factor to seeking treatment. CONCLUSIONS: The information obtained from this study should now be used to guide future morbidity strategies in building a stronger relationship between the local health services and @entity1 @entity0 , in order to ultimately improve @entity0 ' physical, psychological and economic wellbeing. This article is protected by copyright. All rights reserved.

title: Situational Analysis of XXXX Morbidity in Ahanta West District of Ghana.

answer: @entity1


abstract: @entity5 ( @entity5 ) is a rare @entity1 with an incidence of 0.7-2.0 cases/million habitants/year. The diagnosis of @entity1 relies on careful investigations of clinical, biological, and imaging features before surgery and pathological examination after @entity1 removal. Most @entity0 present with @entity2 hormone excess or abdominal mass effects, but 15% of @entity0 with @entity5 is initially diagnosed incidentally. After the diagnosis, in order to assess the @entity5 prognosis and establish an adequate basis for treatment decisions different tools are proposed. The stage classification proposed by the European Network for the Study of @entity1 (ENSAT) is recommended. Pathology reports define the Weiss score, the resection status and the proliferative index, including the mitotic count and the Ki67 index. As far as the treatment is concerned, in case of @entity1 limited to the adrenal gland, the complete resection of the @entity1 is the first option. Most @entity0 benefit from adjuvant @entity7 treatment. In metastatic disease, @entity7 is the cornerstone of initial treatment, and cytotoxic drugs should be added in case of progression. Recently, the First International Randomized (FIRM-ACT) Trial in metastatic @entity5 reported the association between @entity7 and @entity6 / @entity3 / @entity4 (EDP) as the new standard in first line treatment of @entity5 . In last years, new targeted therapies, including the IGF-1 receptor inhibitors, have been investigated, but their efficacy remains limited. Thus, new treatment concepts are urgently needed. The ongoing "omic approaches" and next-generation sequencing will improve our understanding of the pathogenesis and hopefully will lead to better therapies.

title: XXXX ( @entity5 ): diagnosis, prognosis, and treatment.

answer: @entity5


abstract: @entity5 ( @entity5 ) is a rare @entity1 with an incidence of 0.7-2.0 cases/million habitants/year. The diagnosis of @entity1 relies on careful investigations of clinical, biological, and imaging features before surgery and pathological examination after @entity1 removal. Most @entity0 present with @entity2 hormone excess or abdominal mass effects, but 15% of @entity0 with @entity5 is initially diagnosed incidentally. After the diagnosis, in order to assess the @entity5 prognosis and establish an adequate basis for treatment decisions different tools are proposed. The stage classification proposed by the European Network for the Study of @entity1 (ENSAT) is recommended. Pathology reports define the Weiss score, the resection status and the proliferative index, including the mitotic count and the Ki67 index. As far as the treatment is concerned, in case of @entity1 limited to the adrenal gland, the complete resection of the @entity1 is the first option. Most @entity0 benefit from adjuvant @entity7 treatment. In metastatic disease, @entity7 is the cornerstone of initial treatment, and cytotoxic drugs should be added in case of progression. Recently, the First International Randomized (FIRM-ACT) Trial in metastatic @entity5 reported the association between @entity7 and @entity6 / @entity3 / @entity4 (EDP) as the new standard in first line treatment of @entity5 . In last years, new targeted therapies, including the IGF-1 receptor inhibitors, have been investigated, but their efficacy remains limited. Thus, new treatment concepts are urgently needed. The ongoing "omic approaches" and next-generation sequencing will improve our understanding of the pathogenesis and hopefully will lead to better therapies.

title: @entity5 ( XXXX ): diagnosis, prognosis, and treatment.

answer: @entity5


abstract: BACKGROUND: Previous findings on the association between stress during pregnancy and @entity2 are inconsistent. We aimed to estimate this association using a large prospective cohort. METHODS: This population-based study included all 1   303   660 clinically recognised pregnancies in Denmark between 1995 and 2008. We categorised @entity0 as exposed to severe stress if they lost a @entity0 , sibling or parent during pregnancy. Cox Proportional Hazards models were used to study the association between exposure and rate of @entity3 , starting with the follow-up on the day of completion of week 4 of pregnancy. In an attempt to control for unknown potential confounders, we also designed a pregnancy-matched analysis in which each @entity0 had her own baseline risk of @entity2 and controls therefore for genetic and time-stable environmental factors. RESULTS: A total of 146   031 pregnancies ended in clinically recognised fetal loss (11.2%) and a total of 10   808 (0.8%) @entity0 were categorised as exposed. The overall risk of @entity2 was similar in the exposed and unexposed (aHR=1.05, 95% CI 0.95 to 1.15). Results from the pregnancy-matched analysis (performed in 423 @entity0 ) showed stronger and significant associations (aHR=1.83, 95% CI 1.49 to 2.25). All the analyses indicated a stronger effect of bereavement when the mother lost a @entity0 or when the @entity1 was unexpected. CONCLUSIONS: Our main results suggested no strong association between severe stress during pregnancy and risk of @entity2 . Results from the pregnancy-matched analyses considered information from a selected and small group of @entity0 for whom there may exist a stronger association between stress during pregnancy and @entity2 . The fact that an unexpected @entity1 or the loss of a @entity0 had a stronger effect in both analyses may indicate that severe stressful situations increase the risk of @entity2 .

title: Severe stress following bereavement during pregnancy and risk of XXXX : results from a population-based cohort study.

answer: @entity2


abstract: OBJECTIVE: The aim of this study was to determine the effect of plant-based diets on @entity1 . METHODS: @entity0 were enrolled in a 6-mo, five-arm, randomized controlled trial in 2013 in South Carolina. @entity0 attended weekly group meetings, with the exception of the omnivorous group, which served as the control and attended monthly meetings augmented with weekly e-mail lessons. All groups attended monthly meetings for the last 4 mo of the study. Diets did not emphasize caloric restriction. RESULTS: Overweight adults (body mass index 25-49.9 kg/m(2); age 18-65 y, 19% non-white, and 27% @entity0 ) were randomized to a low-fat, low-glycemic index diet: vegan (n = 12), vegetarian (n = 13), pesco-vegetarian (n = 13), semi-vegetarian (n = 13), or omnivorous (n = 12). Fifty (79%) @entity0 completed the study. In intention-to-treat analysis, the linear trend for @entity1 across the five groups was significant at both 2 (P < 0.01) and 6 mo (P < 0.01). At 6 mo, the @entity1 in the vegan group (-7.5%    4.5%) was significantly different from the omnivorous (-3.1%    3.6%; P = 0.03), semi-vegetarian (-3.2%    3.8%; P = 0.03), and pesco-vegetarian (-3.2%    3.4%; P = 0.03) groups. Vegan @entity0 decreased their fat and saturated fat more than the pesco-vegetarian, semi-vegetarian, and omnivorous groups at both 2 and 6 mo (P < 0.05). CONCLUSIONS: Vegan diets may result in greater @entity1 than more modest recommendations.

title: Comparative effectiveness of plant-based diets for XXXX : A randomized controlled trial of five different diets.

answer: @entity1


abstract: UNASSIGNED: @entity2 diuretics (TDs) are a cost-effective first-line therapy for uncomplicated @entity1 ; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic @entity1 @entity0 on monotherapy for @entity1 were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 @entity1 @entity0 , 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated @entity1 .

title: Comparison of the Effect of XXXX Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic @entity0 .

answer: @entity2


abstract: UNASSIGNED: @entity2 diuretics (TDs) are a cost-effective first-line therapy for uncomplicated @entity1 ; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic @entity1 @entity0 on monotherapy for @entity1 were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 @entity1 @entity0 , 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated @entity1 .

title: Comparison of the Effect of @entity2 Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic XXXX .

answer: @entity0


abstract: BACKGROUND: Aging is related to declined cardiac hemodynamic function. As pumping performance may be significantly related to slowed ventricular depolarization and non-synchronous contraction, we hypothesized that aging may cause dysfunction of intercalated disc (ID), which is the structure responsible for intercellular electrical communication between cardiomyocytes. METHODS: Male C57BL/6J @entity0 were used for the study at two ages: 4 and 24 months. Electrocardiographic recording was made to analyze the time of ventricular depolarization. Then @entity0 were killed, and the hearts were harvested for examination in transmission electron microscopy (TEM) and immunofluorescence imaging. The expression of @entity2 ( @entity2 ), @entity3 , and b-catenin in the myocardium of the left ventricle was evaluated using Western blotting. RESULTS: In senescent @entity0 , analysis of averaged QRS complex showed its significant prolongation. At the ultrastructural level, we found frequent disruptions of the ID (affecting 29  5% of them), mainly at the site of adherens junction, with relatively preserved desmosomal intercellular connections and diminished number of gap junctions. Western blotting revealed significantly decreased abundance of @entity2 protein in aged animals, which may cause slowed impulse propagation through the gap junctions and contribute to the observed electrocardiographic alterations. The level of RNA for @entity2 is similar between young and old animals, which suggests a post-transcriptional mechanism of @entity2 protein downregulation. CONCLUSIONS: Our study shows age-related disorganization of ID, which may be responsible for slowed conduction of the depolarization wave within the heart, and supports the hypothesis of @entity1 in senescence.

title: Remodeling of the intercalated disc related to aging in the XXXX heart.

answer: @entity0


abstract: This is an analysis of 71 @entity0 with clinically resectable @entity4 treated with preoperative irradiation and surgery at the University of Florida from July 1975 through December 1981. Seven @entity0 were found to have liver @entity1 at surgery; six had a complete resection of their primary @entity3 and one had an incomplete resection of the @entity2 . The remaining 64 @entity0 had no evidence of @entity1 at the time of surgery and underwent a complete resection of their @entity2 . In the early years of the trial, the maximum @entity2 dose consisted of 3000 to 3500 rad in 3.5 to 4 weeks; the dose was subsequently increased to 4500 rad in 5 weeks. @entity0 were taken to surgery between 2 and 11 weeks (mean, 3.5 weeks) following the completion of radiation therapy. All @entity0 have a minimum follow-up of 3 years and 63% have a minimum follow-up of 5 years. The acute complications of treatment have been acceptable, with only one @entity0 requiring a treatment rest for moist desquamation of the perineum. All @entity0 completed the irradiation course and all were operated on. Pathologic examination of the surgical specimen revealed no @entity2 in 11%, and the incidence of positive lymph nodes was 19%, which was half the incidence of positive lymph nodes in a series of historical controls treated from 1959 to 1976 with surgery alone. Comparison of @entity0 treated with preoperative irradiation and surgery with those treated with surgery alone revealed that the @entity5 have been similar in incidence, distribution, and severity. There have been no postoperative deaths. The overall incidence of local-regional recurrence is 5/64 (7.8%), and the combined incidence of local-regional recurrence and/or distant @entity1 is 18/64 (28%). The incidence of local-regional recurrence by preoperative dose is 3/23 (13%) for doses of 3000 to 3500 rad and 2/41 (5%) for doses of 4000 to 5000 rad. The 5-year local-regional failure rate is 3/40 (7.5%) for the group irradiated before surgery, and 39/135 (29%) for the historical controls managed by surgery alone (significance level = 0.015). The 5-year determinate disease-free survival is 27/38 (71%) for the @entity0 irradiated before surgery, and 47/114 (41%) for the historical group of @entity0 treated with surgery alone (significance level = 0.008).

title: Preoperative radiation therapy for clinically resectable XXXX .

answer: @entity4


abstract: During the past five years, 65 @entity0 were treated for @entity5 unassociated with prior operation. Radiologic tests proved quite accurate in confirming the diagnosis. Abdominal x-ray films were abnormal in 25 (57%) of 44 @entity0 , as were ultrasonograms in 33 (89%) of 37 @entity0 , computed tomography scans in 13 (100%) of 13 @entity0 , and @entity4 scans in five (100%) of five @entity0 . Celiotomy was performed in each @entity0 with both abscess drainage and the appropriate management of the diseased organ. Seven @entity0 (10.8%) died, and in five @entity1 was due to uncontrolled @entity2 . Duration of hospitalization averaged 23 days (seven days preoperatively and 16 days postoperatively). Twenty-two (34%) of 65 @entity0 had an incorrect preoperative diagnosis leading to prolonged antibiotic treatment and delay in operation. The mortality was significant in seven (10.8%) of 65 @entity0 , unrelated to the type of operative drainage (Penrose v sump) but clearly related to uncontrolled @entity3 . A heightened suspicion of this problem should allow for an earlier diagnosis and an improved outcome. Prompt abdominal reexploration is indicated in those @entity0 manifesting continued evidence of @entity2 or organ failure.

title: XXXX unassociated with prior operation.

answer: @entity5


abstract: PURPOSE: @entity3 ( @entity3 ), or Ondine's curse, is a @entity2 affecting central respiratory drive. @entity0 with this disorder fail to ventilate adequately and require lifelong ventilatory support. Diaphragm pacing is a form of ventilatory support which can improve mobility and/or remove the tracheostomy from @entity3 @entity0 . Little is known about complications and long-term outcomes of this procedure. METHODS: A single-center retrospective review was performed of @entity3 @entity0 undergoing placement of phrenic nerve electrodes for diaphragm pacing between 2000 and 2012. Data abstracted from the medical record included operation duration, ventilation method, number of trocars required, and postoperative and pacing outcomes. RESULTS: Charts of eighteen @entity0 were reviewed. Mean surgical time was 3.3  0.7hours. In all cases except one, three trocars were utilized for each hemithorax, with no conversions to open procedures. Five @entity0 (27.8%) experienced @entity1 . The mean ICU stay was 4.3  0.5days, and the mean hospital stay is 5.7  0.3days. Eleven @entity0 (61.1%) achieved their daily goal pacing times within the follow-up period. CONCLUSIONS: Thoracoscopic placement of phrenic nerve electrodes for diaphragmatic pacing is a safe and effective treatment modality for @entity3 . Observed complications were temporary, and the majority of @entity0 were able to achieve pacing goals.

title: Thoracoscopic placement of phrenic nerve pacers for diaphragm pacing in XXXX .

answer: @entity3


abstract: INTRODUCTION: Gradual reduction of the dosage of @entity4 (NE) in @entity0 with @entity3 is usually left to the physician's discretion. No hemodynamic indicator predictive of the possibility of decreasing the NE dosage is currently available at the bedside. The respiratory pulse pressure variation/respiratory @entity1 volume variation (dynamic arterial elastance (Eadyn)) ratio has been proposed as an indicator of vascular tone. The purpose of this study was to determine whether Eadyn can be used to predict the decrease in arterial pressure when decreasing the NE dosage in resuscitated @entity2 @entity0 . METHODS: A prospective study was carried out in a university hospital intensive care unit. All consecutive @entity0 with @entity3 monitored by PICCO2 for whom the intensive care physician planned to decrease the NE dosage were enrolled. Measurements of hemodynamic and PICCO2 variables were obtained before/after decreasing the NE dosage. Responders were defined by a >15% decrease in mean arterial pressure (MAP). RESULTS: In total, 35 @entity0 were included. MAP decreased by >15% after decreasing the NE dosage in 37% of @entity0 (n   =   13). Clinical characteristics appeared to be similar between responders and nonresponders. Eadyn was lower in responders than in nonresponders (0.75 (0.69 to 0.85) versus 1 (0. 83 to 1.22), P   <0.05). Baseline Eadyn was correlated with NE-induced MAP variations (r   =   0.47, P   =   0.005). An Eadyn less than 0.94 predicted a decrease in arterial pressure, with an area under the receiver-operating characteristic curve of 0.87 (95% confidence interval (95% CI): 0.72 to 0.96; P   <0.0001), 100% sensitivity, and 68% specificity. CONCLUSIONS: In @entity2 @entity0 treated with NE, Eadyn may predict the decrease in arterial pressure in response to NE dose reduction. Eadyn may constitute an easy-to-use functional approach to arterial-tone assessment, which may be helpful to identify @entity0 likely to benefit from NE dose reduction.

title: Dynamic arterial elastance predicts mean arterial pressure decrease associated with decreasing XXXX dosage in @entity3 .

answer: @entity4


abstract: INTRODUCTION: Gradual reduction of the dosage of @entity4 (NE) in @entity0 with @entity3 is usually left to the physician's discretion. No hemodynamic indicator predictive of the possibility of decreasing the NE dosage is currently available at the bedside. The respiratory pulse pressure variation/respiratory @entity1 volume variation (dynamic arterial elastance (Eadyn)) ratio has been proposed as an indicator of vascular tone. The purpose of this study was to determine whether Eadyn can be used to predict the decrease in arterial pressure when decreasing the NE dosage in resuscitated @entity2 @entity0 . METHODS: A prospective study was carried out in a university hospital intensive care unit. All consecutive @entity0 with @entity3 monitored by PICCO2 for whom the intensive care physician planned to decrease the NE dosage were enrolled. Measurements of hemodynamic and PICCO2 variables were obtained before/after decreasing the NE dosage. Responders were defined by a >15% decrease in mean arterial pressure (MAP). RESULTS: In total, 35 @entity0 were included. MAP decreased by >15% after decreasing the NE dosage in 37% of @entity0 (n   =   13). Clinical characteristics appeared to be similar between responders and nonresponders. Eadyn was lower in responders than in nonresponders (0.75 (0.69 to 0.85) versus 1 (0. 83 to 1.22), P   <0.05). Baseline Eadyn was correlated with NE-induced MAP variations (r   =   0.47, P   =   0.005). An Eadyn less than 0.94 predicted a decrease in arterial pressure, with an area under the receiver-operating characteristic curve of 0.87 (95% confidence interval (95% CI): 0.72 to 0.96; P   <0.0001), 100% sensitivity, and 68% specificity. CONCLUSIONS: In @entity2 @entity0 treated with NE, Eadyn may predict the decrease in arterial pressure in response to NE dose reduction. Eadyn may constitute an easy-to-use functional approach to arterial-tone assessment, which may be helpful to identify @entity0 likely to benefit from NE dose reduction.

title: Dynamic arterial elastance predicts mean arterial pressure decrease associated with decreasing @entity4 dosage in XXXX .

answer: @entity3


abstract: BACKGROUND: SRQ-20 is a validated screening tool for common @entity1 in several countries. Exploration of the latent structure of this instrument resulted in conflicting evidence. This study aimed to explore the latent structure of SRQ-20 among Brazilian @entity0 from community settings. We also tested the model invariance across different sociodemographic conditions. METHODS: Exploratory factor analysis (EFA) and confirmatory factor analysis ( @entity2 ) were conducted on a sample of 1668 @entity0 from four different geographical regions of Brazil. Invariance of the model was tested through multi-group @entity2 according to sociodemographic variables. RESULTS: EFA has shown two potential solutions with two and three factors. @entity2 resulted in indices of the two-factor solution slightly worse than the three-factor solution. Invariance testing has shown this model was not invariant across cities, but was invariant across different social classes. The structure was also invariant for the two lower educated groups. The respecified model (i.e., excluding item 16) was not invariant across groups with different educational levels. CONCLUSION: The three-factor solution seems to be the most suitable model of SRQ-20 for Brazilian @entity0 in community settings. Furthermore, sociodemographic variables seem to reflect on the latent structure of this instrument. Validation of screening tools should consider sociodemographic variables.

title: Psychometric properties of the self-reporting questionnaire (SRQ-20): Measurement invariance across XXXX from Brazilian community settings.

answer: @entity0


abstract: UNASSIGNED: The objective of this study was to determine the expression and effects of B-lymphocyte stimulator (BLyS) in T cell-mediated @entity4 , a @entity2 model of @entity0 @entity3 ( @entity3 ). @entity2 @entity6 ( @entity6 ) was induced by intradermal injection of 0.1ml complete Freund's adjuvant. @entity4 was evaluated by the histopathological examination of joint ankle. The BLyS expression was detected by immunohistochemical analysis. The level of BLyS and @entity7 were assayed by enzyme-linked immunosorbent assay. The gene expression of BLyS and its receptors (TACI, BCMA and BAFF-R) were assessed by quantitative reverse-transcription polymerase chain reaction. The effect of BLyS on the function of T cell was investigated by transwell assay. Using an @entity6 @entity2 model, we detected dysregulated expression and level of BLyS and its receptors in the local joint synovium tissue, peripheral lymphoid organs (spleen) and immune cells (macrophage, dendritic cells (DC) and T cell) at the peak of @entity1 . In vitro, BLyS-treated DC induced @entity7 producing T cells. Neutralization of BLyS by the TACI-Ig fusion protein attenuated these stimulating effects of BLyS. These data suggest that the overproduction of BLyS may contribute to T cell responses and may be an attractive target for control of @entity5 , such as @entity3 , that involves both T and B cells.

title: Expression and effects of B-lymphocyte stimulator and its receptors in T cell-mediated XXXX .

answer: @entity4


abstract: AIMS: To examine treatment options selected for recurrent stress @entity1 (rSUI) in follow-up after Burch, autologous fascial and synthetic midurethral sling (MUS) procedures. METHODS: We performed a secondary analysis of the SISTER and ToMUS trials of @entity0 who underwent primary stress @entity1 (SUI) treatment (without prior SUI surgery or concomitant procedures). Using Kaplan-Meier analysis, retreatment-free survival rates by initial surgical procedure were compared. Mean MESA (Medical Epidemiologic and Social Aspects of Aging) stress index was also compared between those retreated for rSUI compared to those not retreated. RESULTS: Half of the @entity0 in the SISTEr trial met inclusion criteria for this analysis (329/655, 174 Burch and 155 @entity2 ), as did 444/597 (74%) of subjects in ToMUS (221 transobturator midurethral sling (TMUS), and 223 retropubic midurethral sling (RMUS). Types of surgical retreatment included @entity2 (19), synthetic sling (1), and bulking agent (18). Five-year retreatment free survival rates (and standard errors) were 87% (3%), 96% (2%), 97% (1%), and 99% (0.7%) for Burch, @entity2 , TMUS, and RMUS groups respectively (P   <   0.0001). For all index surgery groups, the mean MESA stress index at last visit prior to retreatment for those retreated (n   =   23) was significantly higher than mean MESA stress index at last visit for those not retreated (n   =   645) (P   <   0.0001). CONCLUSION: In these cohorts, 6% of @entity0 after standard anti- @entity1 procedures were retreated within 5 years, mostly with injection therapy or @entity2 . Not all @entity0 with rSUI chose surgical retreatment.

title: Management of recurrent stress XXXX after burch and sling procedures.

answer: @entity1


abstract: BACKGROUND: It is unclear whether the rate of @entity5 in paediatric @entity1 survivors is higher than in the background population, and whether this is of pathological significance. @entity0 AND METHODS: 25OHD was measured in a previously studied group of 208 survivors (n  =  108 paediatric 5-17  years, n  =  99 adults 18-39  years) and compared with paediatric (5-17  years; n  =  132) and adult controls (25-35  years; n  =  1393 from the AusDiab cohort) adjusted for age and gender. Relationships with treatment factors (irradiation, bone marrow transplantation and intensity of treatment) along with overweight/ @entity2 (defined by BMI), abdominal adiposity (waist:height ratio >0  5) and @entity4 ( @entity4 ) were sought. RESULTS: 25OHD concentrations were similar in paediatric survivors compared with controls (64  3      21  6  nmol/l vs 66  3     22  8  nmol/l), with no effect of age or gender. Adjusted for gender, rates of 25OHD deficiency (<50  nmol/l) were higher in adult survivors compared with AusDiab controls (42  4% vs 20  8%; P  <  0  001). Apart from time since diagnosis (P  =  0  03), no relationship with treatment factors was detected. In multivariate regression analysis, abdominal adiposity (P  =  0  001), but not overweight/ @entity2 by BMI status nor @entity4 , was associated with significantly lower 25OHD concentrations. CONCLUSIONS: Adult survivors are at increased risk of @entity3 compared to the background population, probably reflecting longer time since diagnosis. Like others, we have not identified any contributory treatment-related factors. @entity5 does not appear to be associated with the development of @entity4 in this population.

title: The prevalence of XXXX is higher in adult survivors of childhood @entity1 .

answer: @entity5


abstract: BACKGROUND: It is unclear whether the rate of @entity5 in paediatric @entity1 survivors is higher than in the background population, and whether this is of pathological significance. @entity0 AND METHODS: 25OHD was measured in a previously studied group of 208 survivors (n  =  108 paediatric 5-17  years, n  =  99 adults 18-39  years) and compared with paediatric (5-17  years; n  =  132) and adult controls (25-35  years; n  =  1393 from the AusDiab cohort) adjusted for age and gender. Relationships with treatment factors (irradiation, bone marrow transplantation and intensity of treatment) along with overweight/ @entity2 (defined by BMI), abdominal adiposity (waist:height ratio >0  5) and @entity4 ( @entity4 ) were sought. RESULTS: 25OHD concentrations were similar in paediatric survivors compared with controls (64  3      21  6  nmol/l vs 66  3     22  8  nmol/l), with no effect of age or gender. Adjusted for gender, rates of 25OHD deficiency (<50  nmol/l) were higher in adult survivors compared with AusDiab controls (42  4% vs 20  8%; P  <  0  001). Apart from time since diagnosis (P  =  0  03), no relationship with treatment factors was detected. In multivariate regression analysis, abdominal adiposity (P  =  0  001), but not overweight/ @entity2 by BMI status nor @entity4 , was associated with significantly lower 25OHD concentrations. CONCLUSIONS: Adult survivors are at increased risk of @entity3 compared to the background population, probably reflecting longer time since diagnosis. Like others, we have not identified any contributory treatment-related factors. @entity5 does not appear to be associated with the development of @entity4 in this population.

title: The prevalence of @entity5 is higher in adult survivors of childhood XXXX .

answer: @entity1


abstract: @entity6 produced by @entity3 occurred in 4.5% of the @entity0 hospitalized in our service. Often was associated with duodenal or gastric peptic ulcer, @entity2 and with some other @entity5 ; particularly with ambiasis. Forty four @entity0 were studied in whom the only cause to demonstrate or explain their symptomatology was the presence of @entity3 in the duodenum. The complaints disappeared after the administration of specific treatment. The clinical manifestations remained an atypic @entity4 without defined rhythm or periodicity; however, @entity1 are frequently present. The physical exploration does not help to the diagnosis. Gastric acidity is normal. X-ray studies demonstrate irregular mucosa of the stomach and duodenum and some spastic waves. Duodenoscopy allows to watch inflammatory changes of the duodenal mucosa and rules out peptic ulcer. The diagnosis is confirmed by the demonstration of the parasite, present in the fluid aspirated from the duodenum during the endoscopy.

title: [ XXXX caused by @entity3 ].

answer: @entity6


abstract: @entity6 produced by @entity3 occurred in 4.5% of the @entity0 hospitalized in our service. Often was associated with duodenal or gastric peptic ulcer, @entity2 and with some other @entity5 ; particularly with ambiasis. Forty four @entity0 were studied in whom the only cause to demonstrate or explain their symptomatology was the presence of @entity3 in the duodenum. The complaints disappeared after the administration of specific treatment. The clinical manifestations remained an atypic @entity4 without defined rhythm or periodicity; however, @entity1 are frequently present. The physical exploration does not help to the diagnosis. Gastric acidity is normal. X-ray studies demonstrate irregular mucosa of the stomach and duodenum and some spastic waves. Duodenoscopy allows to watch inflammatory changes of the duodenal mucosa and rules out peptic ulcer. The diagnosis is confirmed by the demonstration of the parasite, present in the fluid aspirated from the duodenum during the endoscopy.

title: [ @entity6 caused by XXXX ].

answer: @entity3


abstract: UNASSIGNED: @entity4 ( @entity4 ) distribution is closely related to @entity1 risk. GH reduces visceral and total body fat mass and induces whole body insulin resistance. Aims: To assess the effects of total and @entity4 ( @entity4 ) distribution and derived adipokines on systemic insulin resistance and lipid metabolism in @entity7 . @entity0 : Seventy adult @entity0 with active @entity7 (43 males, age 49    14 years) were evaluated before and a subset (n = 30, 20 males) was evaluated after treatment. Outcome Measures: Body composition and @entity4 , glucose metabolism parameters, lipids, @entity6 , and selected adipokines ( @entity8 , @entity9 , @entity3 , and leptin) were measured. Results: At baseline @entity4 was positively associated with glucose metabolism parameters, and with lipids. GH, but not @entity2 , was negatively associated with all @entity4 depots (visceral, trunk, limbs, and total) (0.41  <= r  <= 0.61, p < 0.001 for all) and positively associated with @entity8 (r = 0.31, p = 0.013). Fat deposition after treatment was predominantly located on trunk and visceral depots. The lipid profile partially improved, with increases in HDL and @entity5 and a decrease in Lp(a). @entity8 decreased and @entity9 increased. @entity3 and leptin did not significantly change. The improvement in HOMA-IR was best predicted by the decreases in @entity2 and @entity8 and the lack of trunk fat increase (R(2) = 0.59, p = 0.001). Conclusions: (1) @entity4 was a metabolic risk factor for @entity0 with active @entity7 ; (2) @entity8 and @entity9 were influenced by the disease activity but were not associated with @entity4 mass; (3) fat deposition after treatment was predominantly on the trunk and visceral depots; and (4) insulin resistance decreased and the lipid profile partially improved with treatment.    2015 S. Karger AG, Basel.

title: The Metabolic Risk in Newly Diagnosed @entity0 with XXXX is Related to Fat Distribution and Circulating Adipokines and Improves after Treatment.

answer: @entity7


abstract: UNASSIGNED: @entity4 ( @entity4 ) distribution is closely related to @entity1 risk. GH reduces visceral and total body fat mass and induces whole body insulin resistance. Aims: To assess the effects of total and @entity4 ( @entity4 ) distribution and derived adipokines on systemic insulin resistance and lipid metabolism in @entity7 . @entity0 : Seventy adult @entity0 with active @entity7 (43 males, age 49    14 years) were evaluated before and a subset (n = 30, 20 males) was evaluated after treatment. Outcome Measures: Body composition and @entity4 , glucose metabolism parameters, lipids, @entity6 , and selected adipokines ( @entity8 , @entity9 , @entity3 , and leptin) were measured. Results: At baseline @entity4 was positively associated with glucose metabolism parameters, and with lipids. GH, but not @entity2 , was negatively associated with all @entity4 depots (visceral, trunk, limbs, and total) (0.41  <= r  <= 0.61, p < 0.001 for all) and positively associated with @entity8 (r = 0.31, p = 0.013). Fat deposition after treatment was predominantly located on trunk and visceral depots. The lipid profile partially improved, with increases in HDL and @entity5 and a decrease in Lp(a). @entity8 decreased and @entity9 increased. @entity3 and leptin did not significantly change. The improvement in HOMA-IR was best predicted by the decreases in @entity2 and @entity8 and the lack of trunk fat increase (R(2) = 0.59, p = 0.001). Conclusions: (1) @entity4 was a metabolic risk factor for @entity0 with active @entity7 ; (2) @entity8 and @entity9 were influenced by the disease activity but were not associated with @entity4 mass; (3) fat deposition after treatment was predominantly on the trunk and visceral depots; and (4) insulin resistance decreased and the lipid profile partially improved with treatment.    2015 S. Karger AG, Basel.

title: The Metabolic Risk in Newly Diagnosed XXXX with @entity7 is Related to Fat Distribution and Circulating Adipokines and Improves after Treatment.

answer: @entity0


abstract: UNASSIGNED: Background: An @entity2 burden sufficient to put lung transplant candidates at risk for end-organ disease after transplantation is considered to be a relative contraindication for lung transplantation. Objectives: The aim of this study was to assess our current practice of cardiac workup by coronary angiography in lung transplant candidates >= 50 years of age. Methods: We retrospectively analyzed 50 consecutive lung transplant candidates >= 50 years of age in which coronary angiography was performed at the University Hospital Zurich (2009-2013). For every @entity0 , the risk of developing an acute coronary event was estimated by using a recalibrated version of the PROCAM study calculator for the Swiss population. Results: The median estimated risk of developing an acute coronary event within 10 years in the study cohort (n = 50) was 4.2% (interquartile range 1.9-7.6), which is considered to be a low risk. Sixteen percent of @entity0 were considered to be at intermediate risk. In 66% of @entity0 , coronary angiography showed no @entity1 ( @entity1 ). In 28% of @entity0 , @entity1 without significant @entity3 was diagnosed. In 6% of @entity0 , significant @entity4 was detected requiring percutaneous coronary intervention. No correlation between the coronary status and the risk score or cardiovascular risk profile was found. Conclusions: The high prevalence of asymptomatic @entity1 without correlation to a common clinical risk score supports the important role of coronary angiography for the assessment of coronary artery status. This approach might prevent cardiovascular events and improve long-term survival after transplantation.    2015 S. Karger AG, Basel.

title: XXXX in Lung Transplant Candidates: Role of Routine Invasive Assessment.

answer: @entity1


abstract: Evidence is presented that @entity2 enter @entity0 erythrocytes via saturable transport system(s) at rates similar to those previously described for @entity1 (King, G.F. and Kuchel, P.W. (1985) Biochem. J. 227, 833-842) but that the transmembrane flux rates for @entity3 are considerably less. 1H spin-echo NMR spectroscopy was used to monitor the coupled uptake and hydrolysis of peptides by red cells, since it enabled the simultaneous measurement of the levels of substrates and products of peptidase-catalysed reactions in suspensions with haematocrits similar to those found in vivo. Weighted non-linear least-squares regression of the integrated Michaelis-Menten equation onto progress curves obtained from the hydrolysis of @entity5 and @entity4 in RBC lysates gave Km = 2.11 +/- 0.08 and 23.4 +/- 0.9 mmol/l and Vmax = 307 +/- 3 and 905 +/- 22 mmol/h per 1 packed cells, respectively. In whole cell suspensions, the rate of hydrolysis was considerably less and was dominated by the transmembrane flux of @entity2 . Progress curve analysis thus yielded the steady-state kinetic parameters for peptide transport; the values were Km = 11.6 +/- 1.1 and 56 +/- 18 mmol/l and Vmax = 12.9 +/- 3.0 and 36.4 +/- 3.2 mmol/h per 1 packed cells, respectively, for the previously mentioned peptides. The rate of transport of the tetrapeptide @entity6 was considerably less than either of the @entity2 . The above mentioned steady-state kinetic parameters were used in computer simulations of the coupled uptake and hydrolysis of @entity2 by @entity0 erythrocytes under physiological conditions; these simulations revealed certain similarities between the rates of peptide uptake by erythrocytes and the intestine in vivo.

title: The assimilation of tri- and XXXX by @entity0 erythrocytes.

answer: @entity3


abstract: Evidence is presented that @entity2 enter @entity0 erythrocytes via saturable transport system(s) at rates similar to those previously described for @entity1 (King, G.F. and Kuchel, P.W. (1985) Biochem. J. 227, 833-842) but that the transmembrane flux rates for @entity3 are considerably less. 1H spin-echo NMR spectroscopy was used to monitor the coupled uptake and hydrolysis of peptides by red cells, since it enabled the simultaneous measurement of the levels of substrates and products of peptidase-catalysed reactions in suspensions with haematocrits similar to those found in vivo. Weighted non-linear least-squares regression of the integrated Michaelis-Menten equation onto progress curves obtained from the hydrolysis of @entity5 and @entity4 in RBC lysates gave Km = 2.11 +/- 0.08 and 23.4 +/- 0.9 mmol/l and Vmax = 307 +/- 3 and 905 +/- 22 mmol/h per 1 packed cells, respectively. In whole cell suspensions, the rate of hydrolysis was considerably less and was dominated by the transmembrane flux of @entity2 . Progress curve analysis thus yielded the steady-state kinetic parameters for peptide transport; the values were Km = 11.6 +/- 1.1 and 56 +/- 18 mmol/l and Vmax = 12.9 +/- 3.0 and 36.4 +/- 3.2 mmol/h per 1 packed cells, respectively, for the previously mentioned peptides. The rate of transport of the tetrapeptide @entity6 was considerably less than either of the @entity2 . The above mentioned steady-state kinetic parameters were used in computer simulations of the coupled uptake and hydrolysis of @entity2 by @entity0 erythrocytes under physiological conditions; these simulations revealed certain similarities between the rates of peptide uptake by erythrocytes and the intestine in vivo.

title: The assimilation of tri- and @entity3 by XXXX erythrocytes.

answer: @entity0


abstract: UNASSIGNED: The poor response to clopidogrel is multifactorial and includes, amongst others, low @entity0 adherence to medication. The aim of this study was to assess the reported @entity0 adherence to treatment with clopidogrel and confront it with adherence assessed by drug availability. We evaluated determinants of adherence and its impact on @entity2 and clinical outcome. The study population comprised 184 @entity0 treated with primary percutaneous coronary intervention for acute @entity1 . Follow-up visits were scheduled at 3, 6 and 9 months after discharge. @entity0 adherence to clopidogrel was defined according to self-reported drug intake and verified based on data from the National Health Fund regarding the purchase of prescribed drugs. The @entity0 were judged as adherent when the proportion of drug availability exceeded 80%. According to drug availability, 100 (54.3%) @entity0 were adherent and 84 (45.7%) were nonadherent. The analysis identified the following factors as predictors of low adherence (<80%): adenosine diphosphate-induced @entity2 (ADP-PA) during hospitalization  <=45 U, male gender and occurrence of ST-elevation @entity1 [(STEMI) vs. @entity3 ( @entity3 )], while three-vessel disease was predictive of high adherence to medication. Compared with drug availability-based assessment, self-reported drug intake was significantly different: 172 (94.5%) @entity0 reported regular and 10 (5.5%) @entity0 reported irregular intake of clopidogrel. Clinical follow-up suggested that the self-reported nonregular clopidogrel intake may discriminate @entity0 with a high risk of cardiovascular events. We demonstrated a huge discrepancy between the two most widely used methods for the evaluation of adherence to clopidogrel in secondary prevention treatment in @entity0 after STEMI and @entity3 . ADP-PA during hospitalization  <=45 U, male gender and STEMI (vs. @entity3 ) were independent predictors of nonadherence while three-vessel disease was independently predictive of adherence to treatment with clopidogrel in the investigated population.    2015 S. Karger AG, Basel.

title: Discrepancies in Assessment of Adherence to Antiplatelet Treatment after XXXX .

answer: @entity1


abstract: Between January, 1975, and December, 1982, 33 @entity0 underwent mitral valve replacement for @entity5 secondary to @entity3 . The majority were in the seventh decade of life (median age, 62 years), and all were seen with symptoms of @entity1 . Echocardiography was more accurate in making the diagnosis of @entity5 more often (75%) than angiography (66%). Thirty-eight percent of the @entity0 who underwent cineangiography had concomitant @entity2 and had coronary artery bypass grafting as well as mitral valve replacement. There was 1 operative death, an operative mortality of 3%. There were 6 late deaths, a late mortality of 18%. Of the 26 long-term survivors, 23 (88%) were in New York Heart Association Functional Class I and 3 (12%) were in Class II. The average length of follow-up was 33.25 months, and the 5-year actuarial survival was 76%. There was only one incident of @entity4 (3%). Short-term and long-term survival were not related to the severity of @entity1 but to the status of the left ventricle and the overall condition of the @entity0 . These data suggest that older @entity0 with severe @entity1 secondary to @entity5 can undergo valve replacement with low operative mortality and gratifying long-term results.

title: The results of valve replacement for XXXX .

answer: @entity5


abstract: BACKGROUND: Although consensus guidelines for pretreatment evaluation and monitoring of @entity3 therapy in @entity0 with @entity4 ( @entity4 ) have been formulated, little is known about the cardiovascular side effects. OBJECTIVES: We sought to analyze cardiovascular evaluations in @entity0 with @entity4 at baseline and during treatment with an oral beta-blocker. METHODS: Data from 109 @entity0 with @entity4 were retrospectively analyzed. @entity0 and family history, pretreatment electrocardiogram (ECG), heart rate, and blood pressure were evaluated before initiation of beta-blocker therapy. Blood pressure and standardized questionnaires addressing side effects were evaluated during treatment. RESULTS: Questionnaire analyses (n  = 83) identified 3 cases with a family history of @entity1 in first-degree relatives. ECG findings were normal in each case and no serious complication of therapy occurred. ECG abnormalities were found in 6.5% of @entity0 but there were no contraindications to beta-blocker therapy and no major complications. @entity2 in 9 @entity0 did not require therapy adjustment. In all, 88 parents (81%) reported side effects during beta-blocker treatment. LIMITATIONS: The relatively small @entity0 cohort is a limitation. CONCLUSION: Pretreatment ECG is of limited value for @entity0 with an unremarkable cardiovascular history and a normal heart rate and blood pressure. @entity2 may occur during treatment.

title: Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for XXXX ?: A cohort study.

answer: @entity4


abstract: UNASSIGNED: Commensal bacteria and @entity3 ( @entity6 ) have both been shown independently to modulate immune responses. This study tested the hypothesis that the different colonic immunomodulatory responses to commensal ( @entity8 ) and pathogenic bacteria ( @entity0 and @entity1 ) may be modified by @entity6 . Experiments used a Transwell system combining the colorectal cell line HT29, or its mucous secreting sub-clone HT29- @entity4 , with peripheral blood mononuclear cells to analyse immunomodulatory signalling in response to bacteria, with and without prior treatment with @entity2 , @entity7 or @entity5 . @entity8 increased transforming growth factor b1 (TGF-b1) mRNA and protein secretion in colonic cell lines when compared with controls, an effect that was enhanced by pre-treatment with @entity7 . In contrast, the Gram-negative pathogen @entity9 had no significant effect on TGF-b1 protein. @entity8 also increased IL-8 mRNA but not protein while @entity0 increased both; although differences between @entity6 treatments were detected, none were significantly different to controls. Colonic epithelial cells show different immunomodulatory signalling patterns in response to the commensal @entity8 compared to @entity0 and @entity1 and pre-treatment of these cells with @entity6 can modify responses. Practical applications: We have demonstrated an interaction between dietary @entity6 and epithelial cell response to both commensal and pathogenic bacteria found in the gastrointestinal tract by utilising in vitro co-culture models. The data suggest that n-3 @entity6 may provide some protection against the potentially damaging effects of pathogens. Furthermore, the beneficial effects of combining n-3 @entity6 and the commensal bacteria, and potential probiotic, @entity8 are illustrated by the increased expression of immunoregulatory TGF-b1.

title: @entity3 modify expression of TGF-b in a co-culture model ultilising human colorectal cells and human peripheral blood mononuclear cells exposed to @entity8 , XXXX and @entity1 .

answer: @entity0


abstract: UNASSIGNED: Commensal bacteria and @entity3 ( @entity6 ) have both been shown independently to modulate immune responses. This study tested the hypothesis that the different colonic immunomodulatory responses to commensal ( @entity8 ) and pathogenic bacteria ( @entity0 and @entity1 ) may be modified by @entity6 . Experiments used a Transwell system combining the colorectal cell line HT29, or its mucous secreting sub-clone HT29- @entity4 , with peripheral blood mononuclear cells to analyse immunomodulatory signalling in response to bacteria, with and without prior treatment with @entity2 , @entity7 or @entity5 . @entity8 increased transforming growth factor b1 (TGF-b1) mRNA and protein secretion in colonic cell lines when compared with controls, an effect that was enhanced by pre-treatment with @entity7 . In contrast, the Gram-negative pathogen @entity9 had no significant effect on TGF-b1 protein. @entity8 also increased IL-8 mRNA but not protein while @entity0 increased both; although differences between @entity6 treatments were detected, none were significantly different to controls. Colonic epithelial cells show different immunomodulatory signalling patterns in response to the commensal @entity8 compared to @entity0 and @entity1 and pre-treatment of these cells with @entity6 can modify responses. Practical applications: We have demonstrated an interaction between dietary @entity6 and epithelial cell response to both commensal and pathogenic bacteria found in the gastrointestinal tract by utilising in vitro co-culture models. The data suggest that n-3 @entity6 may provide some protection against the potentially damaging effects of pathogens. Furthermore, the beneficial effects of combining n-3 @entity6 and the commensal bacteria, and potential probiotic, @entity8 are illustrated by the increased expression of immunoregulatory TGF-b1.

title: @entity3 modify expression of TGF-b in a co-culture model ultilising human colorectal cells and human peripheral blood mononuclear cells exposed to XXXX , @entity0 and @entity1 .

answer: @entity8


abstract: UNASSIGNED: Commensal bacteria and @entity3 ( @entity6 ) have both been shown independently to modulate immune responses. This study tested the hypothesis that the different colonic immunomodulatory responses to commensal ( @entity8 ) and pathogenic bacteria ( @entity0 and @entity1 ) may be modified by @entity6 . Experiments used a Transwell system combining the colorectal cell line HT29, or its mucous secreting sub-clone HT29- @entity4 , with peripheral blood mononuclear cells to analyse immunomodulatory signalling in response to bacteria, with and without prior treatment with @entity2 , @entity7 or @entity5 . @entity8 increased transforming growth factor b1 (TGF-b1) mRNA and protein secretion in colonic cell lines when compared with controls, an effect that was enhanced by pre-treatment with @entity7 . In contrast, the Gram-negative pathogen @entity9 had no significant effect on TGF-b1 protein. @entity8 also increased IL-8 mRNA but not protein while @entity0 increased both; although differences between @entity6 treatments were detected, none were significantly different to controls. Colonic epithelial cells show different immunomodulatory signalling patterns in response to the commensal @entity8 compared to @entity0 and @entity1 and pre-treatment of these cells with @entity6 can modify responses. Practical applications: We have demonstrated an interaction between dietary @entity6 and epithelial cell response to both commensal and pathogenic bacteria found in the gastrointestinal tract by utilising in vitro co-culture models. The data suggest that n-3 @entity6 may provide some protection against the potentially damaging effects of pathogens. Furthermore, the beneficial effects of combining n-3 @entity6 and the commensal bacteria, and potential probiotic, @entity8 are illustrated by the increased expression of immunoregulatory TGF-b1.

title: @entity3 modify expression of TGF-b in a co-culture model ultilising human colorectal cells and human peripheral blood mononuclear cells exposed to @entity8 , @entity0 and XXXX .

answer: @entity1


abstract: UNASSIGNED: Commensal bacteria and @entity3 ( @entity6 ) have both been shown independently to modulate immune responses. This study tested the hypothesis that the different colonic immunomodulatory responses to commensal ( @entity8 ) and pathogenic bacteria ( @entity0 and @entity1 ) may be modified by @entity6 . Experiments used a Transwell system combining the colorectal cell line HT29, or its mucous secreting sub-clone HT29- @entity4 , with peripheral blood mononuclear cells to analyse immunomodulatory signalling in response to bacteria, with and without prior treatment with @entity2 , @entity7 or @entity5 . @entity8 increased transforming growth factor b1 (TGF-b1) mRNA and protein secretion in colonic cell lines when compared with controls, an effect that was enhanced by pre-treatment with @entity7 . In contrast, the Gram-negative pathogen @entity9 had no significant effect on TGF-b1 protein. @entity8 also increased IL-8 mRNA but not protein while @entity0 increased both; although differences between @entity6 treatments were detected, none were significantly different to controls. Colonic epithelial cells show different immunomodulatory signalling patterns in response to the commensal @entity8 compared to @entity0 and @entity1 and pre-treatment of these cells with @entity6 can modify responses. Practical applications: We have demonstrated an interaction between dietary @entity6 and epithelial cell response to both commensal and pathogenic bacteria found in the gastrointestinal tract by utilising in vitro co-culture models. The data suggest that n-3 @entity6 may provide some protection against the potentially damaging effects of pathogens. Furthermore, the beneficial effects of combining n-3 @entity6 and the commensal bacteria, and potential probiotic, @entity8 are illustrated by the increased expression of immunoregulatory TGF-b1.

title: XXXX modify expression of TGF-b in a co-culture model ultilising human colorectal cells and human peripheral blood mononuclear cells exposed to @entity8 , @entity0 and @entity1 .

answer: @entity3


abstract: BACKGROUND: @entity6 ( @entity6 ) is a common @entity2 . Data is emerging that an independent association between markers of subclinical @entity4 and @entity6 exists and it may be considered as an independent predictor of cardiovascular (CV) outcomes. We aim to better characterize the relationship between @entity6 and inflammatory markers in a multi-ethnic cohort by assessing @entity5 on computed tomography (CT) scans. METHODS: The Multi-Ethnic Study of @entity4 (MESA) is a longitudinal, population-based study from four ethnic groups free of CV disease at baseline. The inflammatory markers studied include: @entity7 ( @entity7 ) and @entity3 ( @entity3 ). On CT scans liver-to-spleen ratio (LSR: Hounsfield Units (HU) of the liver divided by HU of spleen) of <1 and liver attenuation of <40 HU were used as criteria for @entity5 . Unadjusted and adjusted multivariate linear and logistic regression analysis was performed. RESULTS: 4038 @entity0 amongst 6814 MESA population with visible spleen on the CT scan, available @entity7 and @entity3 levels and no reported liver @entity1 were included. The average age was 61 +/- 10 years, 37% Caucasians and 45% were males. Mean @entity7 and @entity3 were 2.36 mg/dl and 1.37 pg/ml respectively. 696 @entity0 (17%) had LSR of <1 and 253 (6%) had liver attenuation of <40 HU. When using LSR <1 as a continuous variable, the correlation (adjusted odds ratio (OR)) with @entity7 >2.0 was 0.037 (95% CI: 0.02-0.054) and with @entity3 was 0.014 (95% CI: 0.004-0.023). On the other hand when presence and absence of LSR <1 was considered, higher ORs for association with @entity8 : 1.41 (95% CI: 1.16 to 1.73) and @entity3 :1.18 (95% CI: 1.05 to 1.31) were found. Similarly, the adjusted association of per unit decrease in liver attenuation with @entity8 was 1.92 (95% CI: 1.20 to 2.63) while for @entity3 was 1.08 (95% CI: 0.69 to 1.47). When considering presence and absence of liver attenuation <40 HU the OR for @entity8 was 2.27 (95% CI: 1.62 to 3.16) and for @entity3 was 1.33 (95% CI: 1.13 to 1.58). CONCLUSION: @entity7 and @entity3 levels were found to be significantly associated with liver fat assessed on CT scan after adjusting for other risk factors for @entity4 .

title: Association between inflammatory markers and liver fat: The Multi-Ethnic Study of XXXX .

answer: @entity4


abstract: OBJECTIVE: Several modalities are available for volumetric measurement of the @entity0 . We discuss the challenges involved in manual segmentation, and analyze the application of alternative methods using automatic segmentation and geometric formulae in measurement of @entity1 volumes and coil packing density. METHODS: The volumes and morphology of 38 @entity1 treated with endovascular coiling at a single center were measured using three-dimensional rotational angiography (3DRA) reconstruction software using automatic segmentation. @entity1 volumes were also calculated from their height, width, depth, size of neck, and assumed shape in 3DRA images using simple geometric formulae. The @entity1 volumes were dichotomized as "small" or "large" using the median volume of the studied population (54 mm(3)) measured by automatic segmentation as the cut-off value for further statistical analysis. RESULTS: A greater proportion of @entity1 were categorized as being "small" when geometric formulae were applied. The median @entity1 volumes obtained were 54.5 mm(3) by 3DRA software, and 30.6 mm(3) using mathematical equations. An underestimation of @entity1 volume with a resultant overestimation in the calculated coil packing density (p = 0.002) was observed. CONCLUSION: Caution must be exercised in the application of simple geometric formulae in the management of @entity0 as volumes may potentially be underestimated and packing densities falsely elevated. Future research should focus on validation of automatic segmentation in volumetric measurement and improving its accuracy to enhance its application in clinical practice.

title: Volume measurement of the XXXX : a discussion and comparison of the alternatives to manual segmentation.

answer: @entity0


abstract: It is not always easy to distinguish between @entity4 with aberration and @entity2 by electrocardiographic analysis alone. M mode echocardiography can often help by providing direct or indirect evidence of the relation between atrial and ventricular contraction. Sixteen consecutive @entity0 with spontaneous sustained @entity3 complex @entity1 with heart rates of 120-225 beats/minute were examined. Echocardiographic evidence of 1:1 conduction was seen in three cases and 2:1 atrioventricular conduction in one (all four had @entity4 , confirmed by intracardiac electrocardiography in three). Evidence of retrograde block was seen in 12 (all had @entity2 , with electrophysiological confirmation in 10). Satisfactory views of the mitral valve were obtained in all @entity0 . @entity0 with @entity2 had a variable mitral valve opening time (range 42-110%) compared with those who had @entity4 (9-15%). Aortic root and left atrial views gave direct evidence of atrial contraction in three cases, and subcostal right atrial wall views were diagnostic in four of five cases. Seven @entity0 with @entity2 had been wrongly diagnosed elsewhere as having @entity4 . This study confirms that echocardiography is a simple and rapid aid to accurate diagnosis in @entity0 with @entity3 complex @entity1 .

title: Role of echocardiography in differential diagnosis of broad complex XXXX .

answer: @entity1


abstract: The prevalence and clinical significance of @entity10 were determined prospectively in 2000 consecutive @entity0 undergoing routine clinical cross sectional echocardiography. Two hundred and twelve @entity0 were excluded because the aortic cusps were not adequately visualised. @entity10 was defined as downward displacement of cuspal material below a line joining the points of attachment of the aortic valve leaflets. Twenty four cases of @entity10 (1.2%) were identified. The @entity0 were aged 12-64 years and nine were @entity0 . All had underlying @entity2 and the commonest lesion (in 11 cases) was prolapse of the larger cusp in bicuspid valves. @entity10 was seen in four @entity0 with @entity9 (two with severe regurgitation), one of whom had marfanoid aortic root dilatation. The remaining examples of aortic prolapse were seen in @entity0 with @entity1 including one with @entity7 , two with @entity8 (one with dissection and one with @entity6 ), and one case of severe @entity4 . Valves destroyed by @entity5 were seen in two cases. @entity10 may be detected in various @entity2 and does not imply the presence of @entity3 , but when bicuspid aortic valves are present it may well be important in producing such regurgitation. Although @entity10 may be associated with severe forms of @entity9 , these @entity0 rarely have @entity3 .

title: Prevalence and clinical significance of XXXX .

answer: @entity10