abstract: We have shown previously that smoking causes a first @entity2 ( @entity2 ) to occur significantly more prematurely in @entity0 than in @entity0 . The aim of the study was to investigate mortality after @entity2 with special emphasis on the impact of smoking and gender. The study included 2,281 consecutive @entity0 (36.8% @entity0 ) who died or were discharged from a central hospital with a diagnosis of @entity2 from 1998 to 2005; the median follow-up of survivors was 7 years. @entity1 after @entity2 was adjusted for confounders. Mean age for @entity0 was 5.8 years older than for @entity0 (76.0 vs. 70.2 years) and @entity0 were less likely to have been smokers. In-hospital mortality for the first @entity2 was 8.9% for @entity0 and 13.3% for @entity0 , and total mortality rates for all indexed @entity2 after 7 years were 47% for @entity0 and 61% for @entity0 . Using Cox regression analysis, with all indexed MIs included, the after-discharge mortality for @entity0 was significantly lower than for @entity0 (hazard ratio 0.82; 95% confidence interval 0.70-0.96; P = 0.015). Compared with non-smokers, @entity0 who were smokers on admission had significantly increased seven-year mortality after discharge (hazard ratio 1.30; 95% confidence interval 1.03-1.63; P = 0.002). In conclusion, current smoking at the time of the indexed @entity2 was associated with increased mortality after 7 years follow-up. The smoking effect was independent of gender. Female gender was associated with a moderately lower risk of @entity1 during the same follow-up period.

title: Mortality after XXXX : impact of gender and smoking status.

answer: @entity2


abstract: Continuous arterio-venous haemofiltration (CAVH), a simple technique not employing pumps, was used for treatment of @entity6 in 25 intensive care @entity0 (mean age 52 +/- 16 [SD] years). @entity6 was due to @entity2 in 9 @entity0 , occurred after surgery in 7 @entity0 and was related to @entity3 in 5 @entity0 , @entity4 in 2 @entity0 and @entity5 in one @entity0 ; in one @entity0 @entity6 developed during pregnancy after preexisting @entity1 . Seventeen @entity0 were oliguric and 8 @entity0 were non-oliguric, with a mean daily urine output of 507 +/- 407 ml. At the start of CAVH the serum @entity8 level was 511 +/- 198 mumol/l. The duration of treatment with CAVH was 1 to 36 days (average 9.3 days). Access to the circulation was by cannulation of the femoral artery and vein in 23 @entity0 and by Scribner shunt in 2 @entity0 . After an initial systemic dose of 2000 IU heparin, a continuous infusion of 250-1000 IU/hr into the arterial blood line was administered, adjusted to a partial thrombin time of 58 +/- 28 sec. With this heparin regimen a single haemofilter could be used for an average time of 2.6 +/- 1.2 days. The mean spontaneous filtration rate was 6 +/- 2 ml/min, resulting in the following serum levels: @entity8 490 +/- 187 mumol/l; @entity9 39 +/- 12.5 mmol/l; @entity7 4.5 +/- 0.5 mmol/l. Nine catheter-associated complications occurred in 5 @entity0 . The most important aspect of CAVH was its simplicity, optimal control of fluid balance and the possibility of unlimited parenteral nutrition. @entity10 was adequately and continuously controlled. Prognosis of ARF was related to the @entity0 ' underlying illness.

title: [Continuous arteriovenous hemofiltration for the treatment of XXXX ].

answer: @entity6


abstract: To assess the impact of an aggressive approach (early operation, graft removal, and extraanatomic bypass) adopted by us 5 years ago in @entity0 with aortic synthetic grafts and @entity3 , we reviewed our 15 year experience with aortoenteric @entity1 in 13 @entity0 . The courses of six @entity0 from the recent series (1979 through 1984) were contrasted with those of seven @entity0 from our earlier series (1968 through 1978). Twelve of 13 @entity0 presented with @entity3 (usually low volume), and no @entity0 presented in shock. Six of seven @entity0 in Series I (earlier series) had positive blood cultures, whereas only two of six in Series II (recent series) had this finding. Of the 13 @entity0 , 10 underwent preoperative endoscopy. It was only with consistent visualization of third and fourth portions of the duodenum that a diagnosis of aortoenteric @entity1 was established (three of four @entity0 75 percent). Although the upper gastrointestinal series was abnormal more frequently (five of seven @entity0 , 71 percent) than arteriograms (three of nine @entity0 , 33 percent), the latter was more specific for a predisposing lesion. At surgery, nine (70 percent) @entity0 had an anastomotic @entity1 and four (30 percent), a false @entity4 . Although only one of seven @entity0 in Series I survived (14 percent), four of six @entity0 in Series II were alive at last follow-up in September 1984 (67 percent). Early diagnosis followed by prompt operation with removal of the synthetic graft and extraanatomic bypass is associated with an improved survival for @entity0 with aortoenteric @entity1 , but the degree of @entity2 as indicated by positive blood cultures appears to be an important prognostic sign.

title: Improvements in the diagnosis and management of aortoenteric XXXX .

answer: @entity1


abstract: The present review deals with 63 adult @entity0 having acute nontuberculous @entity1 treated by early thoracotomy and decortication, during the period from 1955 through 1979. Group I (38 @entity0 ) had postpneumonic @entity1 , but no underlying disease. Group II (25 @entity0 ) had acute @entity1 and one or more serious associated diseases. Positive cultures were present in 45 of 63 @entity0 (71.4%). Most surgeons have customarily recommended conservative management, especially for @entity0 in Group II, because of the supposedly "high risk" involved in decortication. Consequently, the mortality is extremely high. The @entity1 must be cured; a "well drained" or "controlled" @entity1 will not suffice. The severely ill @entity0 can better withstand the ordeal of a major operation than the deleterious effects of a lingering @entity1 . The critically ill @entity0 is best managed by the primary procedure of open thoracotomy and decortication. The author's experience confirms that such @entity0 can expect an outlook (8% mortality) approaching the zero mortality of Group I @entity0 .

title: Early thoracotomy and decortication for nontuberculous XXXX in adults with and without underlying disease. A twenty-five year review.

answer: @entity1


abstract: Since it is impossible to estimate radiation @entity2 in @entity0 , particularly its type and the magnitude of risk, from data obtained from animal experiments, it is necessary to conduct studies directly using epidemiological data on @entity0 populations. In addition to @entity3 , populations subject to occupational exposure and medical exposure are considered as samples for epidemiological study of radiation @entity2 . With regard to @entity3 , the Japanese National Institute of Health and the Atomic Bomb Causality Commission ( @entity5 ) of the U.S. initiated joint programs in 1947, two years after the bombings, and they have energetically engaged in research activities since then. Especially after 1950 a fixed population of approximately 110,000 individuals, composed of @entity3 and non-exposed subjects as controls, was established and a large-scale epidemiological prospective study has been conducted for a long-term follow-up of the population. In 1970 the @entity5 was reorganized as the Radiation Effects Research Foundation, a joint U.S.-Japan research organization, but the research programs have been continued. The results are often cited as the most reliable data available in the reports of both the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR report) and the U.S. Committee on the Biological Effects of Ionizing Radiation (BEIR report), and are also regarded as important data in the calculation of permissible dose (dose limit) by the International Commission on Radiological Protection (ICRP). Scientists from various countries other than the U.S., such as the United Kingdom, Israel, the @entity0 's Republic of China and Indonesia in the capacity of visiting research fellows have engaged in collaborative studies in the fields of epidemiology, immunology, cytogenetics and pathology at the REF Recently a British biostatistician, engaged in an analysis of the follow-up study for a fixed population of approximately 20,000 individuals who underwent radiotherapy for @entity4 in the United Kingdom, joined the Foundation to make a comparative study of research data concerning a fixed population of @entity3 , especially the mortality rate from @entity1 , using the same analytical method as that employed in England and confirmed that the developmental pattern of radiation-induced @entity1 is almost the same in the two populations. This is one typical example of the collaborative studies being carried out. At present, reassessment of radiation dosimetry, which provides a basis for risk estimation, is being conducted with the cooperation of radiation physicists in U.S. and Japan.(ABSTRACT TRUNCATED AT 400 WORDS)

title: ["International cooperation in XXXX research" research on radiation carcinogenicity].

answer: @entity1


abstract: To determine the changes in alveolar PCO2 (PACO2) and @entity2 (PAO2) during periodic and regular breathing epochs in the same @entity0 , we studied 11 preterm @entity0 during quiet sleep (birth weight 1,630 +/- 94 g; gestational age 31 +/- 1 weeks; postnatal age 32 +/- 3 days). A total of 94 breathing/apneic cycles were analyzed and compared with regular periods. During periodic and regular breathing epochs, there were negative correlations of PAO2 on PACO2. Short (< or = 5 s) and long (> 5 s) apneas for individual @entity0 occurred along the regression line for that @entity0 . There was not a single overall critical PACO2 below which @entity1 occurred, but for individual @entity0 the PACO2 and the PAO2 of the breath preceding @entity1 varied within a limited range. @entity1 occurred in clusters of PACO2 and PAO2 along the average regression line of PAO2 on PACO2. Analysis of the data showed that @entity1 occurred at the lowest PACO2 and highest PAO2 levels if allowance was made for circulation time. During @entity1 , 'the best fit' for the increase in PACO2 and the decrease in PAO2 was linear, rather than logarithmic. The findings suggest the following. (1) There is not a single overall critical level of PACO2 for @entity1 to occur, but in a given @entity0 this level varies within a limited range. This indicates that these @entity0 are likely breathing near the @entity1 threshold. (2) Short and long apneas appear to occur randomly along the regression of PAO2 on PACO2 for a particular @entity0 . (3) The changes in alveolar gases are linear during @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Profile of alveolar gases during periodic and regular breathing in preterm XXXX .

answer: @entity0


abstract: In a previous analysis, we identified a point mutation that substituted Pro (CCG) for Leu (CTG) at @entity1 87 in the alpha-subunit of the @entity2 ( @entity2 ) in a Japanese @entity0 with @entity3 . In the present study, we transfected either the wild type (Leu-87) or the mutant (Pro-87) IR cDNA into NIH3T3 cells. Pulse-chase in nonreducing conditions revealed that the dimerization of Pro-87 IR was slightly impaired. However, cell surface biotinylation showed that Pro-87 IR was transported to the cell surface. The Pro-87 IR reduced the insulin binding affinity to about 15% of Leu-87 IR, and the dissociation of insulin in Pro-87 IR was more rapid than in Leu-87 IR. The autophosphorylation of Pro-87 IR was less sensitive to insulin than that of Leu-87 IR, suggesting the reduced insulin binding affinity. Site-directed mutagenesis at @entity1 87 was performed to substitute Ile or Ala for Leu. Both mutant IRs were transported to the cell surface and labeled by cell surface biotinylation. The Ile-87 IR enhanced the insulin binding affinity about 4-fold. The insulin binding affinity of Ala-87 IR was reduced by 85% relative to that of Leu-87 IR. In addition, the dissociation of insulin in Ile-87 IR was slower than in Leu-87 IR, but in Ala-87 IR it was more rapid. These results provide the first direct evidence for a critical role of Leu-87 in binding insulin.

title: Replacements of leucine 87 in @entity0 XXXX alter affinity for insulin.

answer: @entity2


abstract: In a previous analysis, we identified a point mutation that substituted Pro (CCG) for Leu (CTG) at @entity1 87 in the alpha-subunit of the @entity2 ( @entity2 ) in a Japanese @entity0 with @entity3 . In the present study, we transfected either the wild type (Leu-87) or the mutant (Pro-87) IR cDNA into NIH3T3 cells. Pulse-chase in nonreducing conditions revealed that the dimerization of Pro-87 IR was slightly impaired. However, cell surface biotinylation showed that Pro-87 IR was transported to the cell surface. The Pro-87 IR reduced the insulin binding affinity to about 15% of Leu-87 IR, and the dissociation of insulin in Pro-87 IR was more rapid than in Leu-87 IR. The autophosphorylation of Pro-87 IR was less sensitive to insulin than that of Leu-87 IR, suggesting the reduced insulin binding affinity. Site-directed mutagenesis at @entity1 87 was performed to substitute Ile or Ala for Leu. Both mutant IRs were transported to the cell surface and labeled by cell surface biotinylation. The Ile-87 IR enhanced the insulin binding affinity about 4-fold. The insulin binding affinity of Ala-87 IR was reduced by 85% relative to that of Leu-87 IR. In addition, the dissociation of insulin in Ile-87 IR was slower than in Leu-87 IR, but in Ala-87 IR it was more rapid. These results provide the first direct evidence for a critical role of Leu-87 in binding insulin.

title: Replacements of leucine 87 in XXXX @entity2 alter affinity for insulin.

answer: @entity0


abstract: The investigation of many @entity2 currently requires bronchoscopic or surgical histopathological tissue biopsy. This creates risks for @entity0 and entails processing costs and delays in diagnosis. However, several mainly probe-based biophotonic techniques that can image solitary lesions and diffuse @entity2 are fuelling a paradigm shift toward real-time in vivo diagnosis. Optical coherence tomography (OCT) uses near-infrared light in a process analogous to ultrasonography to image the mucosal and submucosal tissue boundaries of the bronchial tree. With 15- m resolution, early work suggests it can differentiate between @entity1 , @entity5 , @entity3 , and @entity6 based around epithelial thickness and breaches in the basement membrane. Probe-based confocal laser endomicroscopy (pCLE) has superior resolution but less penetration than OCT and employs blue argon laser light to fluoresce the endogenous @entity4 of (1) the acinar scaffold of the peripheral lung and (2) the basement membrane lying under bronchial mucosa. Initial studies suggest that the regular fibre arrangement of the basement membrane is altered in the presence of overlying malignant epithelium. pCLE produces detailed representations of the alveolar septal walls, microvessels, and some inflammatory cells. A third device, the endocytoscope, is a contact microscope requiring contrast agent to provide subcellular resolution of bronchial mucosa. Further development of these "optical biopsy" techniques and evaluation of diagnostic sensitivity and specificity of the acquired images are needed before they can be considered effective methods for eliminating the need for, and thus risks of, pinch biopsy to enable real-time diagnosis to streamline management.

title: Progress toward optical biopsy: bringing the microscope to the XXXX .

answer: @entity0


abstract: The aim of this study was to examine the psychometric properties of the @entity4 and Preoccupation about Sleep Questionnaire (APSQ), with a focus on factorial validity and internal consistency as well as discriminative, convergent, and association with @entity2 and @entity3 . Among a randomly selected sample from the general population (N = 5,000), 2,333 @entity0 completed a survey on nighttime symptoms, daytime symptoms, health outcomes, and psychological processes. The study sample consisted of 1800 @entity0 who did not fulfill criteria for another @entity2 than @entity1 . A two-factor solution, accounting for 70.7% of the variance, was extracted from the 10 APSQ items. One six-item factor determined worries about the consequences of poor sleep (a = .91); the second factor, with four items, assessed worries about the uncontrollability of sleep (a = .86). The two factors were significantly intercorrelated (   = .65) and significantly associated with the total APSQ (  s = .97 and .76, respectively). The APSQ and the two subscales showed discriminant validity between three sleep status groups (normal sleep, poor sleep, and @entity1 ; R(2) = .33-.41). The APSQ and the subscales demonstrated convergent validity with measures on cognitive arousal, sleep-related beliefs, @entity4 , and @entity5 . They also were significantly correlated with @entity2 and @entity3 . The findings suggest that the APSQ is a psychometrically sound instrument for assessing worry in @entity1 .

title: Psychometric properties of an @entity1 -specific measure of worry: the XXXX and Preoccupation about Sleep Questionnaire.

answer: @entity4


abstract: The aim of this study was to examine the psychometric properties of the @entity4 and Preoccupation about Sleep Questionnaire (APSQ), with a focus on factorial validity and internal consistency as well as discriminative, convergent, and association with @entity2 and @entity3 . Among a randomly selected sample from the general population (N = 5,000), 2,333 @entity0 completed a survey on nighttime symptoms, daytime symptoms, health outcomes, and psychological processes. The study sample consisted of 1800 @entity0 who did not fulfill criteria for another @entity2 than @entity1 . A two-factor solution, accounting for 70.7% of the variance, was extracted from the 10 APSQ items. One six-item factor determined worries about the consequences of poor sleep (a = .91); the second factor, with four items, assessed worries about the uncontrollability of sleep (a = .86). The two factors were significantly intercorrelated (   = .65) and significantly associated with the total APSQ (  s = .97 and .76, respectively). The APSQ and the two subscales showed discriminant validity between three sleep status groups (normal sleep, poor sleep, and @entity1 ; R(2) = .33-.41). The APSQ and the subscales demonstrated convergent validity with measures on cognitive arousal, sleep-related beliefs, @entity4 , and @entity5 . They also were significantly correlated with @entity2 and @entity3 . The findings suggest that the APSQ is a psychometrically sound instrument for assessing worry in @entity1 .

title: Psychometric properties of an XXXX -specific measure of worry: the @entity4 and Preoccupation about Sleep Questionnaire.

answer: @entity1


abstract: The purpose of this study was to explore in @entity0 with intraventricular haematomas the effectiveness and complication rate of a treatment protocol including standard ventriculostomy and application of urokinase via the catheter. Our series includes 16 @entity0 with severe CT-diagnosed intraparenchymal and predominantly intraventricular @entity2 . In all cases, ventricular drainage was performed. Urokinase treatment was started immediately with intraventricular infusions of 10,000 U urokinase in 5 ml sterile physiological saline every 12 hours. Twelve @entity0 had an excellent outcome, three good and one poor. There were no complications related to urokinase therapy. Side effects of the infusion volume were profuse sweating and @entity1 which were present at 10 ml total infusion volume, but disappeared after reduction to 5 ml. A group of five @entity0 with comparable lesions treated only with ventriculostomy served as controls. Two of them had a good outcome, two a poor one and one died. The late results in the urokinase-treated group were also favourable. Only one of the @entity0 developed @entity3 and was shunted. In the control group, two @entity0 required shunting for delayed @entity3 . We conclude that this protocol for urokinase treatment is safe and effective and can be used in almost all @entity0 with @entity2 .

title: Urokinase infusion for severe XXXX .

answer: @entity2


abstract: BACKGROUNDS/AIMS: To compare surgical results and survival of two groups of @entity0 , age >= 70 vs. age <70, who underwent pancreaticoduodenectomy and to identify the safety of this procedure for elderly @entity0 for the treatment of distal common bile duct (CBD) @entity1 . METHODS: Between January 2003 and December 2009, 55 @entity0 who underwent pancreaticoduodenectomy for the treatment of @entity6 at Keimyung University Dong San Medical Center were enrolled in our study. RESULTS: Of 55 @entity0 , 28 were male and 27 female. Nineteen were over 70 years old (older group) and 36 were below 70 years (younger group). The mean ages of the two groups of @entity0 were 73.5 years and 60.5 years respectively. Although @entity0 of the older group had significantly more @entity2 , perioperative results including operation time, amount of @entity5 , duration of @entity3 were not significantly different. A higher level (more than 5 mg/dl) of preoperative initial @entity4 showed significant correlations with operative morbidity by univariate analysis, and age was not an independent risk factor of operative morbidity. Overall 5 year survival of older and younger groups were 45.9% and 39.5% respectively (p=0.671) and disease-free 5-year survival were 31.7% and 31.1%, respectively (p=0.942). CONCLUSIONS: Surgical outcomes of elderly @entity0 were similar to those of younger @entity0 , despite a higher incidence of comorbid disease. This results shows that pancreaticoduodenectomy can be applied safely to elderly @entity0 .

title: The impact of old age on surgical outcomes after pancreaticoduodenectomy for XXXX .

answer: @entity6


abstract: Introduction. @entity8 is a @entity2 of the diaphragm that is usually diagnosed in the neonatal period and incidentally in asymptomatic adults. Small bowel incarceration in a right-sided @entity8 is exceptional for an adult. Case Presentation. A 54-year-old @entity0 was admitted for acute @entity7 , @entity5 , @entity4 , and fever. Five days before, she had been experiencing an episode of diffuse @entity3 . The admission chest X-ray was interpreted as right @entity6 and pneumothorax with left mediastinal shift. Chest tube drainage was purulent. The thoracoabdominal CT examination suspected an intestinal incarceration through a right diaphragmatic defect. At laparotomy, a right-sided @entity8 was confirmed with a complete @entity1 of the incarcerated caecum. Ileocaecal resection was performed, but the @entity0 died from delayed septic complications. Conclusion. Intrathoracic perforation of the caecum is a rare occurrence; delayed diagnosis due to misleading initial symptoms may lead to severe complications and poor prognosis.

title: Intrathoracic caecal perforation presenting as XXXX .

answer: @entity7


abstract: OBJECTIVES: The aim of the study was to assess the influence of the experience of the surgeon on the occurrence of @entity2 following palatoplasty. MATERIALS AND METHODS: A retrospective review was performed of consecutive @entity0 treated between 2006 and 2013 for @entity3 by a single surgeon. @entity3 repair was performed using the von Langenbeck technique, Furlow palatoplasty, @entity4 . Data was collected for age, sex, date of birth, syndrome, adoption, @entity3 type, type of repair, cleft width, @entity2 occurrence and location of @entity2 . RESULTS: A total of 276 operations were performed in 200 @entity0 (Veau I, II, III, IV). Mean age at surgery was 21.9 months (range: 6.2 months to 26 years 8.3 months). Postoperatively, @entity3 occurred in eight @entity0 (4.0%), however, the incidence was 3.0% in the non-adoption group and 9.7% in the adoption population. In this study there was no statistically significant evidence of a surgical learning curve, and no significant associations between @entity2 rate and sex, adoption, syndrome, @entity3 , cleft width, or type of repair. CONCLUSION AND CLINICAL RELEVANCE: This study demonstrates a @entity2 formation rate of 3.0% for the non-adoption population and 9.7% for the adoption population. There was no statistically significant evidence of a learning curve during the first few years of performing @entity3 repair. No other independent risk factors for @entity1 formation were identified; however, the benefit of a vomer flap and subsequent reduction in @entity2 incidence was demonstrated.

title: Surgical learning curve in performing palatoplasty: A retrospective study in 200 XXXX .

answer: @entity0


abstract: BACKGROUND: Risk factors for poor quality of life (QOL) after @entity5 ( @entity5 ) remain poorly described. OBJECTIVE: To identify the frequency and predictors of poor QOL 1 year after @entity5 . METHODS: We studied 1-year QOL in a prospectively collected cohort of 1181 consecutively admitted @entity5 survivors between July 1996 and May 2013. @entity0 clinical, radiographic, surgical, and acute clinical course information was recorded. Reduced QOL (overall, physical, and psychosocial) at 1 year was assessed with the Sickness Impact Profile and defined as 2 SD below population-based normative Sickness Impact Profile values. Logistic regression leveraging multiple imputation to handle missing data was used to evaluate reduced QOL. RESULTS: Poor overall QOL was observed in 35% of @entity0 . Multivariable analysis revealed that nonwhite ethnicity, high school education or less, history of @entity4 , poor clinical grade (Hunt-Hess Grade >= 3), and delayed @entity6 were predictors of poor overall and psychosocial QOL. Poor physical QOL was additionally associated with older age, @entity7 , @entity1 , and @entity3 . At 1 year, @entity0 with poor QOL had increased difficulty concentrating, @entity2 , @entity4 , and reduced activities of daily living. More than 91% of @entity0 with poor QOL failed to fully return to work. These @entity0 frequently received physical rehabilitation, but few received cognitive rehabilitation or emotional-behavioral support. CONCLUSION: Reduced QOL affects as many as one-third of @entity5 survivors 1 year after @entity5 . Delayed @entity6 is the most important in-hospital modifiable factor that affects QOL. Increased attention to cognitive and emotional difficulties after hospital discharge may help @entity0 achieve greater QOL.

title: Predictors of Poor Quality of Life 1 Year After XXXX .

answer: @entity5


abstract: BACKGROUND: A continuous spinal catheter is a reliable alternative to standard neuraxial techniques in obstetric anesthesia. Despite the potential advantages of intrathecal catheters, they remain underutilized due to fear of @entity2 or post-dural @entity7 @entity1 . In our tertiary care center, intrathecal catheters are either placed intentionally in high-risk obstetric @entity0 or following inadvertent dural @entity7 using a 19-gauge macrocatheter passed through a 17-gauge epidural needle. METHODS: A retrospective review of 761 intrathecal catheters placed from 2001 to 2012 was conducted. An institutional obstetric anesthesia database was used to identify @entity0 with intrathecal catheters. Medical records were reviewed for procedural details and complications. RESULTS: There were no serious complications, including @entity3 , epidural or spinal abscess, @entity4 , @entity6 , or @entity5 , associated with intrathecal catheters. The failure rates were 2.8% (3/108) for intentional placements and 6.1% (40/653) for placements following accidental dural @entity7 . The incidence of post-dural @entity7 @entity1 was 41% (312/761) and the epidural blood patch rate was 31% (97/312). CONCLUSIONS: This review demonstrates that intrathecal catheters are dependable and an option for labor analgesia and surgical anesthesia for cesarean delivery. Serious long-lasting complications are rare.

title: Complications of 761 short-term intrathecal macrocatheters in obstetric XXXX : a retrospective review of cases over a 12-year period.

answer: @entity0


abstract: BACKGROUND: The EUROCARE study collects and analyses survival data from population-based @entity1 registries (CRs) in Europe in order to provide data on between-country differences in survival and time trends in survival. METHODS: This study analyses data on @entity2 , @entity4 (" @entity4 "), and @entity3 diagnosed in 2000-2007 from 88 CRs in 29 countries. Relative survival (RS) was estimated overall, by region, sex, age and period of diagnosis using the complete approach. Time trends in 5-year RS over 1999-2007 were also analysed using the period approach. RESULTS: The prognosis of the studied @entity1 was poor. Age-standardised 5-year RS was 12% for @entity2 , 17% for @entity4 and 7% for @entity3 . There were some between-country differences in survival. In general, RS was low in Eastern Europe and high in Central and Southern Europe. For all sites, 5-year RS was similar in @entity0 and @entity0 and decreased with advancing age. No substantial changes in survival were reported for @entity3 over the period 1999-2007. On average, there was a crude increase in 5-year RS of 3 percentage points between the periods 1999-2001 and 2005-2007 for @entity2 and @entity4 . CONCLUSIONS: The major changes in imaging techniques over the study period for the diagnosis of the three studied @entity1 did not result in an improvement in the prognosis of these @entity1 . In the near future, new innovative treatments might be the best way to improve the prognosis in these @entity1 .

title: Survival in @entity0 with primary @entity2 , @entity4 and XXXX in Europe 1999-2007: Results of EUROCARE-5.

answer: @entity3


abstract: BACKGROUND: The EUROCARE study collects and analyses survival data from population-based @entity1 registries (CRs) in Europe in order to provide data on between-country differences in survival and time trends in survival. METHODS: This study analyses data on @entity2 , @entity4 (" @entity4 "), and @entity3 diagnosed in 2000-2007 from 88 CRs in 29 countries. Relative survival (RS) was estimated overall, by region, sex, age and period of diagnosis using the complete approach. Time trends in 5-year RS over 1999-2007 were also analysed using the period approach. RESULTS: The prognosis of the studied @entity1 was poor. Age-standardised 5-year RS was 12% for @entity2 , 17% for @entity4 and 7% for @entity3 . There were some between-country differences in survival. In general, RS was low in Eastern Europe and high in Central and Southern Europe. For all sites, 5-year RS was similar in @entity0 and @entity0 and decreased with advancing age. No substantial changes in survival were reported for @entity3 over the period 1999-2007. On average, there was a crude increase in 5-year RS of 3 percentage points between the periods 1999-2001 and 2005-2007 for @entity2 and @entity4 . CONCLUSIONS: The major changes in imaging techniques over the study period for the diagnosis of the three studied @entity1 did not result in an improvement in the prognosis of these @entity1 . In the near future, new innovative treatments might be the best way to improve the prognosis in these @entity1 .

title: Survival in @entity0 with primary @entity2 , XXXX and @entity3 in Europe 1999-2007: Results of EUROCARE-5.

answer: @entity4


abstract: BACKGROUND: The EUROCARE study collects and analyses survival data from population-based @entity1 registries (CRs) in Europe in order to provide data on between-country differences in survival and time trends in survival. METHODS: This study analyses data on @entity2 , @entity4 (" @entity4 "), and @entity3 diagnosed in 2000-2007 from 88 CRs in 29 countries. Relative survival (RS) was estimated overall, by region, sex, age and period of diagnosis using the complete approach. Time trends in 5-year RS over 1999-2007 were also analysed using the period approach. RESULTS: The prognosis of the studied @entity1 was poor. Age-standardised 5-year RS was 12% for @entity2 , 17% for @entity4 and 7% for @entity3 . There were some between-country differences in survival. In general, RS was low in Eastern Europe and high in Central and Southern Europe. For all sites, 5-year RS was similar in @entity0 and @entity0 and decreased with advancing age. No substantial changes in survival were reported for @entity3 over the period 1999-2007. On average, there was a crude increase in 5-year RS of 3 percentage points between the periods 1999-2001 and 2005-2007 for @entity2 and @entity4 . CONCLUSIONS: The major changes in imaging techniques over the study period for the diagnosis of the three studied @entity1 did not result in an improvement in the prognosis of these @entity1 . In the near future, new innovative treatments might be the best way to improve the prognosis in these @entity1 .

title: Survival in @entity0 with primary XXXX , @entity4 and @entity3 in Europe 1999-2007: Results of EUROCARE-5.

answer: @entity2


abstract: BACKGROUND: The EUROCARE study collects and analyses survival data from population-based @entity1 registries (CRs) in Europe in order to provide data on between-country differences in survival and time trends in survival. METHODS: This study analyses data on @entity2 , @entity4 (" @entity4 "), and @entity3 diagnosed in 2000-2007 from 88 CRs in 29 countries. Relative survival (RS) was estimated overall, by region, sex, age and period of diagnosis using the complete approach. Time trends in 5-year RS over 1999-2007 were also analysed using the period approach. RESULTS: The prognosis of the studied @entity1 was poor. Age-standardised 5-year RS was 12% for @entity2 , 17% for @entity4 and 7% for @entity3 . There were some between-country differences in survival. In general, RS was low in Eastern Europe and high in Central and Southern Europe. For all sites, 5-year RS was similar in @entity0 and @entity0 and decreased with advancing age. No substantial changes in survival were reported for @entity3 over the period 1999-2007. On average, there was a crude increase in 5-year RS of 3 percentage points between the periods 1999-2001 and 2005-2007 for @entity2 and @entity4 . CONCLUSIONS: The major changes in imaging techniques over the study period for the diagnosis of the three studied @entity1 did not result in an improvement in the prognosis of these @entity1 . In the near future, new innovative treatments might be the best way to improve the prognosis in these @entity1 .

title: Survival in XXXX with primary @entity2 , @entity4 and @entity3 in Europe 1999-2007: Results of EUROCARE-5.

answer: @entity0


abstract: BACKGROUND: We provide updated estimates of survival and survival trends of @entity3 (prostate, testicular and @entity1 ), in Europe and across European areas. METHODS: The complete approach was used to obtain relative survival estimates for @entity0 diagnosed in 2000-2007, and followed up through 2008 in 29 countries. Data came from 87 @entity1 registries (CRs) for @entity2 and from 86 CRs for testis and penis @entity1 . Relative survival time trends in 1999-2007 were estimated by the period approach. Data came from 49 CRs in 25 countries. RESULTS: We analysed 1,021,275 @entity3 cases. Five-year relative survival was high and decreased with increasing age for all @entity1 considered. We found limited variation in survival between European regions with Eastern Europe countries having lower survival than the others. Survival for @entity1 @entity0 did not improve from 1999 to 2007. Survival for @entity1 @entity0 remained stable at high levels since 1999. Survival for @entity2 @entity0 increased over time. CONCLUSIONS: Treatment standardisation and centralisation for very rare diseases such as @entity1 or advanced @entity1 should be supported. The high survival of @entity1 makes long-term monitoring of @entity1 survivors necessary and CRs can be an important resource. @entity2 @entity0 ' survival must be interpreted considering incidence and mortality data. The follow-up of the European Randomised Study of Screening for @entity2 should continue to clarify the impact of screening on @entity2 mortality together with population based studies including information on stage and treatments.

title: Survival of XXXX (prostate, testis and penis) in Europe 1999-2007: Results from the EUROCARE-5 study.

answer: @entity3


abstract: OBJECTIVES: Three-year survival is 80% for @entity4 ) positive tonsillar and base of @entity3 (TSCC and BOTSCC) and higher (95-100%) in @entity0 with @entity1 without HLA class I expression, or with high @entity2 (+) @entity1 -infiltrating lymphocyte (TIL) counts. The former paradoxical, the latter expected, but it is known that @entity6 can downregulate HLA class I expression. Furthermore, upon HPV integration, E2, sometimes in combination with E5 is lost. Here, @entity5 E2, @entity6 mRNA was therefore examined in relation to HLA class I expression, TIL counts and survival. @entity0 AND METHODS: @entity5 DNA positive TSCC and BOTSCC biopsies, analyzed for HLA class I and @entity2 (+) TILs, of 133 @entity0 , treated curatively between 2000 and 2011, were tested for @entity5 E2, @entity6 mRNA expression. Totally 127 samples could be evaluated and of these 117 @entity0 , all with @entity5 /E7-mRNA-positive @entity1 , were included in the final analysis. RESULTS: Most @entity1 (92%) expressed E7 mRNA, and of these 64% also expressed @entity7 mRNA. @entity0 with @entity1 lacking E2 mRNA had worse 3-year relapse and progression free survival (p<0.01 and p<0.05), while presence of E5 had no impact on clinical outcome. Furthermore, HLA class I expression and TILs were not correlated to E5 or to E2 mRNA expression. CONCLUSION: Lack of E2 but not E5 mRNA in @entity5 positive TSCC and BOTSCC was a negative prognostic marker. Presence of @entity5 E2, @entity6 mRNA expression was not correlated to HLA class I expression or @entity2 (+) TILs.

title: Studies on @entity4 ) 16 E2, XXXX mRNA in @entity1 in relation to clinical outcome and immunological parameters.

answer: @entity6


abstract: OBJECTIVES: Three-year survival is 80% for @entity4 ) positive tonsillar and base of @entity3 (TSCC and BOTSCC) and higher (95-100%) in @entity0 with @entity1 without HLA class I expression, or with high @entity2 (+) @entity1 -infiltrating lymphocyte (TIL) counts. The former paradoxical, the latter expected, but it is known that @entity6 can downregulate HLA class I expression. Furthermore, upon HPV integration, E2, sometimes in combination with E5 is lost. Here, @entity5 E2, @entity6 mRNA was therefore examined in relation to HLA class I expression, TIL counts and survival. @entity0 AND METHODS: @entity5 DNA positive TSCC and BOTSCC biopsies, analyzed for HLA class I and @entity2 (+) TILs, of 133 @entity0 , treated curatively between 2000 and 2011, were tested for @entity5 E2, @entity6 mRNA expression. Totally 127 samples could be evaluated and of these 117 @entity0 , all with @entity5 /E7-mRNA-positive @entity1 , were included in the final analysis. RESULTS: Most @entity1 (92%) expressed E7 mRNA, and of these 64% also expressed @entity7 mRNA. @entity0 with @entity1 lacking E2 mRNA had worse 3-year relapse and progression free survival (p<0.01 and p<0.05), while presence of E5 had no impact on clinical outcome. Furthermore, HLA class I expression and TILs were not correlated to E5 or to E2 mRNA expression. CONCLUSION: Lack of E2 but not E5 mRNA in @entity5 positive TSCC and BOTSCC was a negative prognostic marker. Presence of @entity5 E2, @entity6 mRNA expression was not correlated to HLA class I expression or @entity2 (+) TILs.

title: Studies on XXXX ) 16 E2, @entity6 mRNA in @entity1 in relation to clinical outcome and immunological parameters.

answer: @entity4


abstract: OBJECTIVES: Three-year survival is 80% for @entity4 ) positive tonsillar and base of @entity3 (TSCC and BOTSCC) and higher (95-100%) in @entity0 with @entity1 without HLA class I expression, or with high @entity2 (+) @entity1 -infiltrating lymphocyte (TIL) counts. The former paradoxical, the latter expected, but it is known that @entity6 can downregulate HLA class I expression. Furthermore, upon HPV integration, E2, sometimes in combination with E5 is lost. Here, @entity5 E2, @entity6 mRNA was therefore examined in relation to HLA class I expression, TIL counts and survival. @entity0 AND METHODS: @entity5 DNA positive TSCC and BOTSCC biopsies, analyzed for HLA class I and @entity2 (+) TILs, of 133 @entity0 , treated curatively between 2000 and 2011, were tested for @entity5 E2, @entity6 mRNA expression. Totally 127 samples could be evaluated and of these 117 @entity0 , all with @entity5 /E7-mRNA-positive @entity1 , were included in the final analysis. RESULTS: Most @entity1 (92%) expressed E7 mRNA, and of these 64% also expressed @entity7 mRNA. @entity0 with @entity1 lacking E2 mRNA had worse 3-year relapse and progression free survival (p<0.01 and p<0.05), while presence of E5 had no impact on clinical outcome. Furthermore, HLA class I expression and TILs were not correlated to E5 or to E2 mRNA expression. CONCLUSION: Lack of E2 but not E5 mRNA in @entity5 positive TSCC and BOTSCC was a negative prognostic marker. Presence of @entity5 E2, @entity6 mRNA expression was not correlated to HLA class I expression or @entity2 (+) TILs.

title: Studies on @entity4 ) 16 E2, @entity6 mRNA in XXXX in relation to clinical outcome and immunological parameters.

answer: @entity1


abstract: There is an agreement that acute (in minutes) hydrolysis and accumulation of @entity5 ( @entity5 ) modulate @entity8 and @entity7 activities. Because @entity0 results in PIP(2) depletion, persisting for long periods (hours to days) in @entity1 models and in the clinic, we examined whether chronic depletion and accumulation of PIP(2) affect @entity6 (CAP) and mustard oil (MO) responses. In addition, we wanted to evaluate whether the effects of @entity5 depend on @entity8 and @entity7 coexpression and whether the PIP(2) actions vary in expression cells vs. sensory neurons. Chronic @entity5 production was stimulated by overexpression of @entity4 -5-kinase, and PIP(2) -specific phospholipid 5'-phosphatase was selected to reduce plasma membrane levels of @entity5 . Our results demonstrate that CAP (100 nM) responses and receptor tachyphylaxis are not significantly influenced by chronic changes in @entity5 levels in @entity2 ( @entity2 ) or @entity7 null-mutant sensory neurons as well as CHO cells expressing @entity8 alone or with @entity7 . However, low concentrations of CAP (20 nM) produced a higher response after PIP(2) depletion in cells containing @entity8 alone but not @entity8 together with @entity7 . MO (25  M) responses were also not affected by PIP(2) in @entity2 sensory neurons and cells coexpressing @entity7 and @entity8 . In contrast, @entity5 reduction leads to pronounced tachyphylaxis to MO in cells with both channels. Chronic effect of @entity5 on @entity7 activity depends on presence of the @entity8 channel and cell type ( @entity3 vs. sensory neurons). In summary, chronic alterations in PIP(2) levels regulate magnitude of CAP and MO responses as well as MO tachyphylaxis. This regulation depends on coexpression profile of @entity7 and @entity8 and cell type.

title: Chronic alteration in phosphatidylinositol 4,5-biphosphate levels regulates XXXX and mustard oil responses.

answer: @entity6


abstract: Psychosocial aspects are considered nowadays to fill a very important function in the rehabilitation of severe @entity2 . The high prevalence of @entity4 ( @entity4 ) makes it representative in this field. Mainly acute in the beginning, with a strong probability of becoming chronic latter on, @entity4 constitutes a threaten to the individual. @entity1 and @entity3 when to strong or to prolonged in time may become maladaptive and contribute to a delay in recovery. In this case a specialized approach is needed that must be individually adapted. This approach includes counselling, focalized psychotherapeutic intervention, exploration of fears and fantasies related to the illness and use of psychotropic drugs. On the other hand, family dynamics and interpersonal relationships are frequently related to the maintenance of maladjusted roles that can delay the return to active life. Professional problems and conflicts are sometimes obstacles to professional and social reintegration. All the described aspects recommend nowadays the organization of multidisciplinary rehabilitation teams as the only way of providing differentiated and multifocal approaches. The inclusion of mental health professionals in rehabilitation teams allows a better adequacy of their programs to @entity0 and families emotional needs.

title: [The role of the psychiatrist in rehabilitating the XXXX with ischemic cardiopathy].

answer: @entity0


abstract: INTRODUCTION: Intralesional surgery of @entity2 of the bone ( @entity4 ) may result in a high rate of local recurrence. The introduction of local adjuvants, such as cementation, cryosurgery or phenolization, has proved to be successful in the reduction of recurrence rates. This study presents the results of a single institution in surgery of @entity4 with an evolution in treatment strategies. MATERIAL _ METHODS: Forty primary and 25 recurrent surgical procedures in 46 @entity0 with @entity4 of the bone with a median follow-up of 72 months were reviewed retrospectively. The mean age was 32.6 years (range 13.6-57.9 years). Forty-seven curettages and 18 resections were performed. For the curettages, a large bone window was cut followed by high speed burring and bone grafting or cementation. In 34 of 47 curettages and 7 of 18 resections, @entity5 was additionally applied. RESULTS: Two @entity0 showed @entity3 , one died due to @entity1 . In total, a third of the @entity0 developed local recurrence (32.3%). This was evenly spread among primary and recurrent diesease (32.5% vs. 32%). Seven of 13 curettages without adjuvant recurred (53.9%), compared to 11 of 34 curettages with adjuvant @entity5 (32.4%). Three of 18 resections developed a recurrence (16.7%). No complications in respect to the use of @entity5 were seen. DISCUSSION: Phenolization is a safe local adjuvant therapy for @entity4 . Although the recurrence rate was lower with the use of @entity5 , this drop was not significant. The comparable high recurrence rate in our study, even if @entity5 was used, might be due to the fact that curettage was our favoured treatment, even in cases with an extensive @entity2 . We recommend adjuvant phenolization in the treatment of @entity4 of the bone after thorough curettage in applicable cases, including where cementation is used for defect filling.

title: The influence of adjuvants on local recurrence rate in XXXX of the bone.

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to determine the effects of bivalved versus circumferential cast immobilization on maintenance of reduction and associated complications after closed reduction (CR) of radius and/or ulna @entity2 in @entity0 . METHODS: Two hundred two @entity0 with displaced radius and/or ulna @entity2 were randomized to either circumferential (n=101) or bivalved (n=101) long-arm casts after CR. The mean age was 10  3 years. There were no significant differences between groups in terms of age, sex, or initial @entity2 or angulation. Clinical and radiographic evaluations were performed at 1, 2, 4, and 6 weeks postreduction. Radiographic loss of reduction (LOR), need for remanipulation or surgery, and associated complications of @entity4 , cast saw @entity3 were recorded. RESULTS: Overall, the median angulation of the radius and ulna @entity2 improved from 20 and 18 degrees to 3 and 2 degrees after CR, respectively. The median cast index after reduction was 0.78 in the bivalved group and 0.80 in the circumferential group. The median angulation of the radius and ulna was 8 and 1 degrees at 4 weeks, with no significant difference between groups. By the fourth week of follow-up, 70 @entity0 (34%)-35 bivalved and 35 circumferential-had radiographic LOR. Forty-seven @entity0 (23%)-23 bivalved and 24 circumferential-underwent remanipulation or surgical reduction and fixation. There were no significant differences between groups with respect to LOR rate or need for surgical treatment. One bivalved @entity0 sustained a cast saw injury, and 3 bivalved @entity0 had transient @entity1 . No @entity0 developed @entity4 . CONCLUSIONS: Cast immobilization is effective in the majority of @entity0 after CR of displaced @entity2 . There were no significant differences in maintenance of reduction, need for surgery, or complications between bivalved or circumferential long-arm casts. LEVEL OF EVIDENCE: Level I-therapeutic.

title: Bivalved Versus Circumferential Cast Immobilization for Displaced XXXX : A Randomized Clinical Trial to Assess Efficacy and Safety.

answer: @entity2


abstract: BACKGROUND: In @entity0 with @entity4 ( @entity4 ), @entity1 are associated with @entity5 , @entity2 , apical @entity3 , and mortality. The cause of @entity1 remains unresolved, and there is controversy about prevalence and significance of mid-left ventricular (LV) obstruction, often present in these @entity0 . The aim of this study was to test the hypothesis that low velocities in @entity0 with @entity1 are due to near complete cessation of mid-LV flow, characteristically marked by a Doppler signal void. METHODS: This was a retrospective analysis of 39 @entity0 with @entity4 with segmental @entity6 of the mid left ventricle and complete systolic emptying at the mid-LV level. The severity of @entity8 was evaluated by measuring the time during which cross-sectional mid-LV cavity area was <1  cm(2). Presence or absence of an LV Doppler midsystolic signal void was determined. RESULTS: Akinetic @entity1 were present in 21 @entity0 . The duration of two-dimensional mid-LV short-axis complete emptying was longer in @entity0 with @entity1 (194      45 vs 148      63  msec, P  =  .013), nearly 50% of systole. Midsystolic signal voids were seen only in @entity0 with @entity1 (P  <  .001), present in 86%. In @entity0 with @entity1 , there was a strong correlation between the duration of the systolic signal void and the proportion of systole with complete emptying <1  cm(2) (r  =  0.704; P  =  .001). Complete emptying <1  cm(2) for >= 38% of systole was associated with @entity1 (odds ratio, 9.35; P  <  .004). CONCLUSION: @entity0 with @entity7 apical @entity1 @entity4 have near complete cessation of flow across severe dynamic mid-LV obstruction for nearly 50% of systole. This explains how the adverse effects of obstruction may occur without high velocities on echocardiography.

title: Doppler Systolic Signal Void in XXXX : Apical @entity1 and Severe Obstruction without Elevated Intraventricular  Velocities.

answer: @entity4


abstract: BACKGROUND: In @entity0 with @entity4 ( @entity4 ), @entity1 are associated with @entity5 , @entity2 , apical @entity3 , and mortality. The cause of @entity1 remains unresolved, and there is controversy about prevalence and significance of mid-left ventricular (LV) obstruction, often present in these @entity0 . The aim of this study was to test the hypothesis that low velocities in @entity0 with @entity1 are due to near complete cessation of mid-LV flow, characteristically marked by a Doppler signal void. METHODS: This was a retrospective analysis of 39 @entity0 with @entity4 with segmental @entity6 of the mid left ventricle and complete systolic emptying at the mid-LV level. The severity of @entity8 was evaluated by measuring the time during which cross-sectional mid-LV cavity area was <1  cm(2). Presence or absence of an LV Doppler midsystolic signal void was determined. RESULTS: Akinetic @entity1 were present in 21 @entity0 . The duration of two-dimensional mid-LV short-axis complete emptying was longer in @entity0 with @entity1 (194      45 vs 148      63  msec, P  =  .013), nearly 50% of systole. Midsystolic signal voids were seen only in @entity0 with @entity1 (P  <  .001), present in 86%. In @entity0 with @entity1 , there was a strong correlation between the duration of the systolic signal void and the proportion of systole with complete emptying <1  cm(2) (r  =  0.704; P  =  .001). Complete emptying <1  cm(2) for >= 38% of systole was associated with @entity1 (odds ratio, 9.35; P  <  .004). CONCLUSION: @entity0 with @entity7 apical @entity1 @entity4 have near complete cessation of flow across severe dynamic mid-LV obstruction for nearly 50% of systole. This explains how the adverse effects of obstruction may occur without high velocities on echocardiography.

title: Doppler Systolic Signal Void in @entity4 : Apical XXXX and Severe Obstruction without Elevated Intraventricular  Velocities.

answer: @entity1


abstract: OBJECTIVES: This study evaluates the feasibility of chemosensitivity testing by use of endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) samples and determines the optimum cut-off value for @entity2 . METHODS: Thirty-four consecutive @entity0 with unresectable @entity3 were enrolled. Chemosensitivity (treated/control ratio: T/C ratio) was calculated as the quantity of @entity4 for a @entity1 treated with @entity2 as a percentage of that for the control. To identify the cut-off value sufficient to predict 180  days of progression-free survival (PFS), the receiver operating characteristic curve and the corresponding area under the curve (AUC) were calculated. RESULTS: The success of this assay was 88.2% (30/34); therefore, 30 @entity0 were assessable and included in the population of analyzable @entity0 .. The response was 6.7%. Median PFS was 96  days and median overall survival was 241  days, respectively. The cut-off value was determined as 74% (AUC, 0.745; p  =  0.053; 95% CI 0.485-1.005). According to this cut-off value, we predicted 180  days PFS with a sensitivity and specificity of 71.4 and 91.3%, respectively. When @entity0 were divided into two groups at T/C ratio 74%, a significant difference was found in PFS (median 77 vs. 205  days, p  =  0.0036). Moreover, T/C ratio  <  74% and decrease of CA19-9 were significant and independent prognostic factors by multivariate analysis. CONCLUSION: Chemosensitivity testing by use of EUS-FNA samples in @entity0 with unresectable @entity3 is feasible. This definition emphasizes the possibility of selecting @entity0 for whom favorable results from @entity2 treatment can be expected.

title: @entity4 assay-guided chemosensitivity testing for @entity2 with biopsy specimens obtained from unresectable XXXX using endoscopic ultrasonography-guided fine-needle aspiration.

answer: @entity3


abstract: OBJECTIVES: This study evaluates the feasibility of chemosensitivity testing by use of endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) samples and determines the optimum cut-off value for @entity2 . METHODS: Thirty-four consecutive @entity0 with unresectable @entity3 were enrolled. Chemosensitivity (treated/control ratio: T/C ratio) was calculated as the quantity of @entity4 for a @entity1 treated with @entity2 as a percentage of that for the control. To identify the cut-off value sufficient to predict 180  days of progression-free survival (PFS), the receiver operating characteristic curve and the corresponding area under the curve (AUC) were calculated. RESULTS: The success of this assay was 88.2% (30/34); therefore, 30 @entity0 were assessable and included in the population of analyzable @entity0 .. The response was 6.7%. Median PFS was 96  days and median overall survival was 241  days, respectively. The cut-off value was determined as 74% (AUC, 0.745; p  =  0.053; 95% CI 0.485-1.005). According to this cut-off value, we predicted 180  days PFS with a sensitivity and specificity of 71.4 and 91.3%, respectively. When @entity0 were divided into two groups at T/C ratio 74%, a significant difference was found in PFS (median 77 vs. 205  days, p  =  0.0036). Moreover, T/C ratio  <  74% and decrease of CA19-9 were significant and independent prognostic factors by multivariate analysis. CONCLUSION: Chemosensitivity testing by use of EUS-FNA samples in @entity0 with unresectable @entity3 is feasible. This definition emphasizes the possibility of selecting @entity0 for whom favorable results from @entity2 treatment can be expected.

title: XXXX assay-guided chemosensitivity testing for @entity2 with biopsy specimens obtained from unresectable @entity3 using endoscopic ultrasonography-guided fine-needle aspiration.

answer: @entity4


abstract: OBJECTIVES: This study evaluates the feasibility of chemosensitivity testing by use of endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) samples and determines the optimum cut-off value for @entity2 . METHODS: Thirty-four consecutive @entity0 with unresectable @entity3 were enrolled. Chemosensitivity (treated/control ratio: T/C ratio) was calculated as the quantity of @entity4 for a @entity1 treated with @entity2 as a percentage of that for the control. To identify the cut-off value sufficient to predict 180  days of progression-free survival (PFS), the receiver operating characteristic curve and the corresponding area under the curve (AUC) were calculated. RESULTS: The success of this assay was 88.2% (30/34); therefore, 30 @entity0 were assessable and included in the population of analyzable @entity0 .. The response was 6.7%. Median PFS was 96  days and median overall survival was 241  days, respectively. The cut-off value was determined as 74% (AUC, 0.745; p  =  0.053; 95% CI 0.485-1.005). According to this cut-off value, we predicted 180  days PFS with a sensitivity and specificity of 71.4 and 91.3%, respectively. When @entity0 were divided into two groups at T/C ratio 74%, a significant difference was found in PFS (median 77 vs. 205  days, p  =  0.0036). Moreover, T/C ratio  <  74% and decrease of CA19-9 were significant and independent prognostic factors by multivariate analysis. CONCLUSION: Chemosensitivity testing by use of EUS-FNA samples in @entity0 with unresectable @entity3 is feasible. This definition emphasizes the possibility of selecting @entity0 for whom favorable results from @entity2 treatment can be expected.

title: @entity4 assay-guided chemosensitivity testing for XXXX with biopsy specimens obtained from unresectable @entity3 using endoscopic ultrasonography-guided fine-needle aspiration.

answer: @entity2


abstract: BACKGROUND/AIMS: The aim of this study was to investigate the expressions of some of the Mucus Core Proteins (MUC) @entity5 , @entity9 and @entity8 in @entity4 , to assess their prognostic values and their relations with the clinicopathological characteristics. METHODS: @entity5 , @entity9 and @entity8 expressions were investigated immunohistochemically in 257 @entity0 with @entity4 . RESULTS: @entity5 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation (92.6% in well differentiated @entity2 , 83.7% in poorly differentiated @entity2 ), with an increase in the number of metastatic lymph nodes (98.4% in @entity2 with no metastatic lymph nodes, 67.9% in @entity2 with lymph node metastasis-pN3), and with the progression in the @entity2 stage (100% in stage 1 @entity2 , 75.6% in stage 4 @entity2 ). @entity5 expression was lower in distant @entity1 (83.3% in distant @entity1 and 90.8% in @entity2 ). There was no staining with @entity9 in normal gastric epithelium; however, de novo expressions appeared in tumoral tissues. In @entity4 ( @entity6 ), @entity9 expression was higher (97.5% in diffuse type and 89.4% in intestinal type). All of the @entity3 were @entity9 -positive. The expression rate decreased with an increase in the number of metastatic lymph nodes and with the progression in the TNM stages of the cases. All of the @entity2 with intestinal metaplasia were @entity9 -positive. @entity8 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation, with an increase in the @entity2 invasion depth, and with an increase in the number of metastatic lymph nodes. @entity8 expression was higher in @entity7 (48.4%) than in the diffuse type (10%). The lowest expression rate was in the diffuse type according to the Borrmann's macroscopic classification. All of these results were statistically significant (p<0.05). CONCLUSIONS: When each of these three markers is evaluated, in the light of clinical and pathological parameters, @entity5 and @entity8 may be accepted as significant prognostic parameters and may be useful in showing the progression of the @entity2 ; @entity9 may be used in determining the @entity3 .

title: Prognostic significance of XXXX , @entity9 and @entity8 expressions in @entity4 .

answer: @entity5


abstract: BACKGROUND/AIMS: The aim of this study was to investigate the expressions of some of the Mucus Core Proteins (MUC) @entity5 , @entity9 and @entity8 in @entity4 , to assess their prognostic values and their relations with the clinicopathological characteristics. METHODS: @entity5 , @entity9 and @entity8 expressions were investigated immunohistochemically in 257 @entity0 with @entity4 . RESULTS: @entity5 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation (92.6% in well differentiated @entity2 , 83.7% in poorly differentiated @entity2 ), with an increase in the number of metastatic lymph nodes (98.4% in @entity2 with no metastatic lymph nodes, 67.9% in @entity2 with lymph node metastasis-pN3), and with the progression in the @entity2 stage (100% in stage 1 @entity2 , 75.6% in stage 4 @entity2 ). @entity5 expression was lower in distant @entity1 (83.3% in distant @entity1 and 90.8% in @entity2 ). There was no staining with @entity9 in normal gastric epithelium; however, de novo expressions appeared in tumoral tissues. In @entity4 ( @entity6 ), @entity9 expression was higher (97.5% in diffuse type and 89.4% in intestinal type). All of the @entity3 were @entity9 -positive. The expression rate decreased with an increase in the number of metastatic lymph nodes and with the progression in the TNM stages of the cases. All of the @entity2 with intestinal metaplasia were @entity9 -positive. @entity8 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation, with an increase in the @entity2 invasion depth, and with an increase in the number of metastatic lymph nodes. @entity8 expression was higher in @entity7 (48.4%) than in the diffuse type (10%). The lowest expression rate was in the diffuse type according to the Borrmann's macroscopic classification. All of these results were statistically significant (p<0.05). CONCLUSIONS: When each of these three markers is evaluated, in the light of clinical and pathological parameters, @entity5 and @entity8 may be accepted as significant prognostic parameters and may be useful in showing the progression of the @entity2 ; @entity9 may be used in determining the @entity3 .

title: Prognostic significance of @entity5 , @entity9 and @entity8 expressions in XXXX .

answer: @entity4


abstract: BACKGROUND/AIMS: The aim of this study was to investigate the expressions of some of the Mucus Core Proteins (MUC) @entity5 , @entity9 and @entity8 in @entity4 , to assess their prognostic values and their relations with the clinicopathological characteristics. METHODS: @entity5 , @entity9 and @entity8 expressions were investigated immunohistochemically in 257 @entity0 with @entity4 . RESULTS: @entity5 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation (92.6% in well differentiated @entity2 , 83.7% in poorly differentiated @entity2 ), with an increase in the number of metastatic lymph nodes (98.4% in @entity2 with no metastatic lymph nodes, 67.9% in @entity2 with lymph node metastasis-pN3), and with the progression in the @entity2 stage (100% in stage 1 @entity2 , 75.6% in stage 4 @entity2 ). @entity5 expression was lower in distant @entity1 (83.3% in distant @entity1 and 90.8% in @entity2 ). There was no staining with @entity9 in normal gastric epithelium; however, de novo expressions appeared in tumoral tissues. In @entity4 ( @entity6 ), @entity9 expression was higher (97.5% in diffuse type and 89.4% in intestinal type). All of the @entity3 were @entity9 -positive. The expression rate decreased with an increase in the number of metastatic lymph nodes and with the progression in the TNM stages of the cases. All of the @entity2 with intestinal metaplasia were @entity9 -positive. @entity8 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation, with an increase in the @entity2 invasion depth, and with an increase in the number of metastatic lymph nodes. @entity8 expression was higher in @entity7 (48.4%) than in the diffuse type (10%). The lowest expression rate was in the diffuse type according to the Borrmann's macroscopic classification. All of these results were statistically significant (p<0.05). CONCLUSIONS: When each of these three markers is evaluated, in the light of clinical and pathological parameters, @entity5 and @entity8 may be accepted as significant prognostic parameters and may be useful in showing the progression of the @entity2 ; @entity9 may be used in determining the @entity3 .

title: Prognostic significance of @entity5 , @entity9 and XXXX expressions in @entity4 .

answer: @entity8


abstract: BACKGROUND/AIMS: The aim of this study was to investigate the expressions of some of the Mucus Core Proteins (MUC) @entity5 , @entity9 and @entity8 in @entity4 , to assess their prognostic values and their relations with the clinicopathological characteristics. METHODS: @entity5 , @entity9 and @entity8 expressions were investigated immunohistochemically in 257 @entity0 with @entity4 . RESULTS: @entity5 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation (92.6% in well differentiated @entity2 , 83.7% in poorly differentiated @entity2 ), with an increase in the number of metastatic lymph nodes (98.4% in @entity2 with no metastatic lymph nodes, 67.9% in @entity2 with lymph node metastasis-pN3), and with the progression in the @entity2 stage (100% in stage 1 @entity2 , 75.6% in stage 4 @entity2 ). @entity5 expression was lower in distant @entity1 (83.3% in distant @entity1 and 90.8% in @entity2 ). There was no staining with @entity9 in normal gastric epithelium; however, de novo expressions appeared in tumoral tissues. In @entity4 ( @entity6 ), @entity9 expression was higher (97.5% in diffuse type and 89.4% in intestinal type). All of the @entity3 were @entity9 -positive. The expression rate decreased with an increase in the number of metastatic lymph nodes and with the progression in the TNM stages of the cases. All of the @entity2 with intestinal metaplasia were @entity9 -positive. @entity8 was strongly expressed in normal gastric epithelium; however, the expression rate decreased with the loss of @entity2 differentiation, with an increase in the @entity2 invasion depth, and with an increase in the number of metastatic lymph nodes. @entity8 expression was higher in @entity7 (48.4%) than in the diffuse type (10%). The lowest expression rate was in the diffuse type according to the Borrmann's macroscopic classification. All of these results were statistically significant (p<0.05). CONCLUSIONS: When each of these three markers is evaluated, in the light of clinical and pathological parameters, @entity5 and @entity8 may be accepted as significant prognostic parameters and may be useful in showing the progression of the @entity2 ; @entity9 may be used in determining the @entity3 .

title: Prognostic significance of @entity5 , XXXX and @entity8 expressions in @entity4 .

answer: @entity9


abstract: Tissue @entity1 tensions were measured in the @entity2 9L @entity6 under conditions of normal air breathing or @entity10 breathing and after intravenous administration of a hemoglobin solution with air breathing or @entity10 breathing. Administration of the hemoglobin decreased the level of @entity3 in the @entity0 . Treatment of the animals with the antiangiogenic combination of @entity8 and @entity5 also increased @entity0 oxygenation compared with untreated controls. Treatment with the antiangiogenic agents along with administration of the hemoglobin solution/ @entity10 breathing decreased the @entity3 fraction (% @entity7 readings < or = 5 mmHg) from 71 % to 30%. Treatment of the @entity0 -bearing animals with BCNU or @entity4 modestly reduced @entity3 in the @entity0 , while treatment with fractionated radiation markedly increased @entity3 in the @entity0 . @entity0 growth delay was used to assess the response of the subcutaneous @entity0 to the various treatment combinations. There was a strong correlation between increased therapeutic response and @entity0 . @entity0 growth delay from BCNU increased from 5.3 days to 16.4 days with @entity8 /- @entity5 /hemoglobin solution/ @entity10 . Similarly, the @entity0 growth delay from @entity4 increased from 3.9 days to 17.0 days with @entity8 / @entity5 /hemoglobin solution/ @entity10 . Finally, the @entity0 growth delay from fractionated radiation increased from 4.8 days to 13.3 days with @entity8 / @entity5 /hemoglobin solution/ @entity10 . When @entity9 was added to the complete radiation regimen, the @entity0 growth delay increased further to 20.5 days. These data show that the addition of non-toxic agents that increase @entity0 oxygenation to cytotoxic therapies can markedly increase therapeutic response.

title: Increased efficacy of chemo- and radio-therapy by a hemoglobin solution in the 9L XXXX .

answer: @entity6


abstract: A 54-year-old @entity0 was admitted for mitral valvular repair. After folding plasty to A3, a 30 mm Cosgrove-Edwards ring was placed. There was no @entity2 jet observed by transesophageal echocardiography (TEE) during the operation. However, @entity1 was monitored and treated in the intensive care unit, @entity6 developed, and the serum @entity4 dehydrogenase level was elevated. Two weeks after the operation, serum @entity4 dehydrogenase was again elevated. TEE showed mild @entity2 and the regurgitation jet colliding with the annuloplasty ring. Multiple transfusions of red blood cells were required. Repeat surgery was therefore undertaken. @entity7 and associates previously studying @entity0 on @entity5 after mitral valvular repair noted high grade @entity2 jets fragmented or accelerated. In the present case, @entity2 was mild, but the high velocity and manner of regurgitation (collision with the annuloplasty ring) could cause @entity6 . In the present case, @entity1 might have caused chordae @entity3 . Furthermore, a flexible ring, such as the Cosgrove-Edwards ring, is likely to cause @entity6 . As contributing factors to @entity5 after mitral valvular repair, perioperative blood pressure management and type of ring are significant.

title: [A Case of Mitral Valvular Re-repair in a @entity0 with XXXX after Mitral Valvular Repair].

answer: @entity6


abstract: A 54-year-old @entity0 was admitted for mitral valvular repair. After folding plasty to A3, a 30 mm Cosgrove-Edwards ring was placed. There was no @entity2 jet observed by transesophageal echocardiography (TEE) during the operation. However, @entity1 was monitored and treated in the intensive care unit, @entity6 developed, and the serum @entity4 dehydrogenase level was elevated. Two weeks after the operation, serum @entity4 dehydrogenase was again elevated. TEE showed mild @entity2 and the regurgitation jet colliding with the annuloplasty ring. Multiple transfusions of red blood cells were required. Repeat surgery was therefore undertaken. @entity7 and associates previously studying @entity0 on @entity5 after mitral valvular repair noted high grade @entity2 jets fragmented or accelerated. In the present case, @entity2 was mild, but the high velocity and manner of regurgitation (collision with the annuloplasty ring) could cause @entity6 . In the present case, @entity1 might have caused chordae @entity3 . Furthermore, a flexible ring, such as the Cosgrove-Edwards ring, is likely to cause @entity6 . As contributing factors to @entity5 after mitral valvular repair, perioperative blood pressure management and type of ring are significant.

title: [A Case of Mitral Valvular Re-repair in a XXXX with @entity6 after Mitral Valvular Repair].

answer: @entity0


abstract: PURPOSE: @entity6 of the mandible (DSO) is a rare and poorly understood disease. Current treatment protocols, including @entity4 or analgesic medication and corticotomies, show poor or frustrating outcome results and are accompanied by potentially severe side effects. The aim of this study was to determine whether there is a beneficial role of infusions with @entity5 -containing @entity3 ( @entity8 ) in acute conditions of DSO. MATERIAL AND METHODS: Eleven @entity0 were enrolled in the study. In acute conditions of treatment-resistant DSO, single-shot infusions of @entity8 (6  mg) were administered. @entity2 levels were documented 10 days before and after the infusion on a visual analogue scale (VAS). @entity0 were monitored regularly. RESULTS: Of the 11 @entity0 , 10 showed a distinct improvement in @entity2 (based on VAS scores) within 48-72  h after infusion. The @entity2 levels of the @entity0 were significantly lower after @entity8 infusions (p  <  0.01). The majority of @entity0 were free or almost free of complaints over the following months. Four of the 11 @entity0 returned for repeated infusions. At the time of writing, no severe side effects have been observed, and in particular there has been no case of medication-related @entity1 . CONCLUSION: We conclude that single-shot @entity7 infusions on demand are promising treatment alternatives in acute DSO. Single-shot @entity7 infusions of @entity8 were well tolerated and resulted in distinct, long lasting improvement in subjective @entity2 levels based on VAS scores.

title: @entity8 treatment of XXXX of the mandible: @entity2 relief and insight into pathogenesis.

answer: @entity6


abstract: PURPOSE: @entity6 of the mandible (DSO) is a rare and poorly understood disease. Current treatment protocols, including @entity4 or analgesic medication and corticotomies, show poor or frustrating outcome results and are accompanied by potentially severe side effects. The aim of this study was to determine whether there is a beneficial role of infusions with @entity5 -containing @entity3 ( @entity8 ) in acute conditions of DSO. MATERIAL AND METHODS: Eleven @entity0 were enrolled in the study. In acute conditions of treatment-resistant DSO, single-shot infusions of @entity8 (6  mg) were administered. @entity2 levels were documented 10 days before and after the infusion on a visual analogue scale (VAS). @entity0 were monitored regularly. RESULTS: Of the 11 @entity0 , 10 showed a distinct improvement in @entity2 (based on VAS scores) within 48-72  h after infusion. The @entity2 levels of the @entity0 were significantly lower after @entity8 infusions (p  <  0.01). The majority of @entity0 were free or almost free of complaints over the following months. Four of the 11 @entity0 returned for repeated infusions. At the time of writing, no severe side effects have been observed, and in particular there has been no case of medication-related @entity1 . CONCLUSION: We conclude that single-shot @entity7 infusions on demand are promising treatment alternatives in acute DSO. Single-shot @entity7 infusions of @entity8 were well tolerated and resulted in distinct, long lasting improvement in subjective @entity2 levels based on VAS scores.

title: @entity8 treatment of @entity6 of the mandible: XXXX relief and insight into pathogenesis.

answer: @entity2


abstract: PURPOSE: @entity6 of the mandible (DSO) is a rare and poorly understood disease. Current treatment protocols, including @entity4 or analgesic medication and corticotomies, show poor or frustrating outcome results and are accompanied by potentially severe side effects. The aim of this study was to determine whether there is a beneficial role of infusions with @entity5 -containing @entity3 ( @entity8 ) in acute conditions of DSO. MATERIAL AND METHODS: Eleven @entity0 were enrolled in the study. In acute conditions of treatment-resistant DSO, single-shot infusions of @entity8 (6  mg) were administered. @entity2 levels were documented 10 days before and after the infusion on a visual analogue scale (VAS). @entity0 were monitored regularly. RESULTS: Of the 11 @entity0 , 10 showed a distinct improvement in @entity2 (based on VAS scores) within 48-72  h after infusion. The @entity2 levels of the @entity0 were significantly lower after @entity8 infusions (p  <  0.01). The majority of @entity0 were free or almost free of complaints over the following months. Four of the 11 @entity0 returned for repeated infusions. At the time of writing, no severe side effects have been observed, and in particular there has been no case of medication-related @entity1 . CONCLUSION: We conclude that single-shot @entity7 infusions on demand are promising treatment alternatives in acute DSO. Single-shot @entity7 infusions of @entity8 were well tolerated and resulted in distinct, long lasting improvement in subjective @entity2 levels based on VAS scores.

title: XXXX treatment of @entity6 of the mandible: @entity2 relief and insight into pathogenesis.

answer: @entity8


abstract: PURPOSE: Medical information on male anorectics is scant. We present data on 10 males with @entity5 , who were treated at our Eating Disorders Center during a twelve-year period. METHODS: Retrospective chart review. RESULTS: All @entity0 were malnourished weighing 80% or less of their ideal body weight with a mean B.M.I. of 13.5 +/- 2.0. Height below the 50th percentile was evident in 80% of the @entity0 , and was below the 10th percentile in 30% of the @entity0 . Structural brain changes on brain computerized tomography scans were noted in seven out of nine @entity0 and more than 50% had mild @entity2 relative to the Tanner stage. Other findings included a mean presenting heart rate of 68.3 +/- 17: four out of ten @entity0 had presenting heart rates of 80 or greater and of these, three had serious medical problems and were severely malnourished. Two @entity0 had @entity1 and one had a life-threatening electrolyte disturbance. CONCLUSION: Despite the small number of @entity0 , the proportion of male adolescent anorectics with medical abnormalities seems high, and may be due to difficulties in establishing the diagnosis and delay in seeking medical attention. @entity0 who had heart rates of 80 or greater were perhaps sicker and further along in their development of @entity4 , thus explaining their initial relative @entity3 . We suggest a higher index of suspicion for @entity4 and closer medical monitoring when a malnourished adolescent with @entity5 presents with relatively elevated heart rates.

title: Medical complications in male adolescents with XXXX .

answer: @entity5


abstract: BACKGROUND: To assess the short-term outcomes of intracorporeal Roux-en-Y esophagojejunostomy using the transorally inserted anvil (OrVil) compared with extracorporeal circular Roux-en-Y @entity3 during laparoscopic total gastrectomy (LTG) for @entity4 . METHODS: From January 2011-April 2014, a total of 165 consecutive @entity0 with @entity4 underwent either intracorporeal Roux-en-Y esophagojejunostomy (n  =  25) using the Orvil or extracorporeal circular @entity3 (n  =  140) during LTG. After generating propensity scores with six covariates, including gender, age, body mass index (BMI), Eastern Cooperative Oncology Group performance status, @entity1 location, and @entity1 size, 25 @entity0 undergoing the OrVil method (intracorporeal group) were one-to-one matched with 25 @entity0 undergoing the extracorporeal method (extracorporeal group). The short-term outcomes were compared between the two groups. RESULTS: Both groups were balanced regarding baseline variables. The total operative time was not significantly different between the two groups (216.5      24.9  min versus 224.0      30.5  min, P  =  0.344), whereas either the duration of anvil insertion (9.9      2.4  min versus 12.9      2.0  min, P  <  0.001) or reconstruction completion (44.4      9.4  min versus 50.1      5.4  min, P  =  0.012) in the intracorporeal group was less. The mean length of minilaparotomy in the intracorporeal group was shorter (5.6      0.4  cm versus 7.2      1.7  cm, P  <  0.001). No significant differences were observed in intraoperative complication rate, estimated @entity2 , length of proximal margin, or postoperative recovery course (including the time to first flatus, liquid resumption, liquid, and soft diet) between the two groups. No @entity0 suffered from @entity5 . The overall morbidity rates of 28.0% in the intracorporeal group and 32.0% in the extracorporeal group were comparable (P  =  0.758). CONCLUSIONS: Intracorporeal Roux-en-Y esophagojejunostomy using the transorally inserted anvil system may be a safe procedure during LTG for @entity4 . However, a longer follow-up in a well-designed randomized controlled trial is necessary to more thoroughly evaluate this technique.

title: Short-term outcomes of intracorporeal esophagojejunostomy using the transorally inserted anvil versus extracorporeal circular XXXX during laparoscopic total gastrectomy for @entity4 : a propensity score matching analysis.

answer: @entity3


abstract: BACKGROUND: To assess the short-term outcomes of intracorporeal Roux-en-Y esophagojejunostomy using the transorally inserted anvil (OrVil) compared with extracorporeal circular Roux-en-Y @entity3 during laparoscopic total gastrectomy (LTG) for @entity4 . METHODS: From January 2011-April 2014, a total of 165 consecutive @entity0 with @entity4 underwent either intracorporeal Roux-en-Y esophagojejunostomy (n  =  25) using the Orvil or extracorporeal circular @entity3 (n  =  140) during LTG. After generating propensity scores with six covariates, including gender, age, body mass index (BMI), Eastern Cooperative Oncology Group performance status, @entity1 location, and @entity1 size, 25 @entity0 undergoing the OrVil method (intracorporeal group) were one-to-one matched with 25 @entity0 undergoing the extracorporeal method (extracorporeal group). The short-term outcomes were compared between the two groups. RESULTS: Both groups were balanced regarding baseline variables. The total operative time was not significantly different between the two groups (216.5      24.9  min versus 224.0      30.5  min, P  =  0.344), whereas either the duration of anvil insertion (9.9      2.4  min versus 12.9      2.0  min, P  <  0.001) or reconstruction completion (44.4      9.4  min versus 50.1      5.4  min, P  =  0.012) in the intracorporeal group was less. The mean length of minilaparotomy in the intracorporeal group was shorter (5.6      0.4  cm versus 7.2      1.7  cm, P  <  0.001). No significant differences were observed in intraoperative complication rate, estimated @entity2 , length of proximal margin, or postoperative recovery course (including the time to first flatus, liquid resumption, liquid, and soft diet) between the two groups. No @entity0 suffered from @entity5 . The overall morbidity rates of 28.0% in the intracorporeal group and 32.0% in the extracorporeal group were comparable (P  =  0.758). CONCLUSIONS: Intracorporeal Roux-en-Y esophagojejunostomy using the transorally inserted anvil system may be a safe procedure during LTG for @entity4 . However, a longer follow-up in a well-designed randomized controlled trial is necessary to more thoroughly evaluate this technique.

title: Short-term outcomes of intracorporeal esophagojejunostomy using the transorally inserted anvil versus extracorporeal circular @entity3 during laparoscopic total gastrectomy for XXXX : a propensity score matching analysis.

answer: @entity4


abstract: The results of 102 @entity0 with @entity2 of the femur shaft treated by osteosynthesis with dynamic compression plates (DCP) in comparison to 87 @entity0 which underwent a conservative treatment by extension are presented. Of 329 @entity0 in a 15-years period, 238 @entity0 had a follow-up examination with evaluable data and 49 @entity0 were excluded because of a different therapy such as plaster traction, cast, osteosynthesis with screws or nails etc. The @entity0 were divided into two groups: series I from 1968 to 1977 and series II from 1978 to 1982. 19.6% of the @entity0 had a residual difference of more than 1 cm in the length of the legs. Operated @entity0 were twice as often afflicted as the conservative group. The amount of difference in the length depended on the duration of instability and increased when several repositions were required in the conservative group, or when an operation was carried out secondary to inadequate traction therapy. Axial deviation was found to be much more common in the extended group (16.1%) than in the operated group, in which only 4% axial deviations persisted in series II when DC-plates were used exclusively. Predominant in the conservative group was a persisting antecurvation in 13 of 14 @entity0 . Residual rotation malalignment of significant degree was found only in the group treated by extension, while the operated group averosed at minor @entity1 . @entity0 with closed epiphysis on the date of examination, who had a persisting rotation failure, had been treated nearly exclusively by extension (50% versus 15%).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Late results following femoral shaft XXXX in childhood].

answer: @entity2


abstract: Changes in intracellular @entity0 concentrations ([ @entity0 ]i) are an important signal for various physiological activities. The @entity1 / @entity0 exchangers (NCX) at the plasma membrane transport @entity0 into or out of the cell according to the electrochemical gradients of @entity1 and @entity0 to modulate [ @entity0 ]i homeostasis. @entity2 ( @entity2 ) senses [ @entity0 ]i changes and relays @entity0 signals by binding to target proteins such as channels and transporters. However, it is not clear how @entity2 modulates NCX activity. Using @entity2 as a bait, we pulled down the intracellular loops subcloned from the @entity3 splice variants @entity3 .1 and @entity3 .3. This interaction requires both @entity0 and a putative @entity2 -binding segment (CaMS). To determine whether @entity2 modulates NCX activity, we co-expressed @entity3 splice variants with @entity2 or CaM1234 (a @entity0 -binding deficient mutant) in HEK293T cells and measured the increase in [ @entity0 ]i contributed by the influx of @entity0 through NCX. Deleting the CaMS from @entity3 .1 and @entity3 .3 attenuated exchange activity and decreased membrane localization. Without the mutually exclusive exon, the exchange activity was decreased and could be partially rescued by CaM1234. Point-mutations at any of the 4 conserved a.a. residues in the CaMS had differential effects in @entity3 .1 and @entity3 .3. Mutating the first two conserved a.a. in @entity3 .1 decreased exchange activity; mutating the 3rd or 4th conserved a.a. residues did not alter exchange activity, but @entity2 co-expression suppressed activity. Mutating the 2nd and 3rd conserved a.a. residues in @entity3 .3 decreased exchange activity. Taken together, our results demonstrate that @entity2 senses changes in [ @entity0 ]i and binds to the cytoplasmic loop of @entity3 to regulate exchange activity.

title: @entity2 Interacts with the Sodium/Calcium Exchanger XXXX to Regulate Activity.

answer: @entity3


abstract: Changes in intracellular @entity0 concentrations ([ @entity0 ]i) are an important signal for various physiological activities. The @entity1 / @entity0 exchangers (NCX) at the plasma membrane transport @entity0 into or out of the cell according to the electrochemical gradients of @entity1 and @entity0 to modulate [ @entity0 ]i homeostasis. @entity2 ( @entity2 ) senses [ @entity0 ]i changes and relays @entity0 signals by binding to target proteins such as channels and transporters. However, it is not clear how @entity2 modulates NCX activity. Using @entity2 as a bait, we pulled down the intracellular loops subcloned from the @entity3 splice variants @entity3 .1 and @entity3 .3. This interaction requires both @entity0 and a putative @entity2 -binding segment (CaMS). To determine whether @entity2 modulates NCX activity, we co-expressed @entity3 splice variants with @entity2 or CaM1234 (a @entity0 -binding deficient mutant) in HEK293T cells and measured the increase in [ @entity0 ]i contributed by the influx of @entity0 through NCX. Deleting the CaMS from @entity3 .1 and @entity3 .3 attenuated exchange activity and decreased membrane localization. Without the mutually exclusive exon, the exchange activity was decreased and could be partially rescued by CaM1234. Point-mutations at any of the 4 conserved a.a. residues in the CaMS had differential effects in @entity3 .1 and @entity3 .3. Mutating the first two conserved a.a. in @entity3 .1 decreased exchange activity; mutating the 3rd or 4th conserved a.a. residues did not alter exchange activity, but @entity2 co-expression suppressed activity. Mutating the 2nd and 3rd conserved a.a. residues in @entity3 .3 decreased exchange activity. Taken together, our results demonstrate that @entity2 senses changes in [ @entity0 ]i and binds to the cytoplasmic loop of @entity3 to regulate exchange activity.

title: XXXX Interacts with the Sodium/Calcium Exchanger @entity3 to Regulate Activity.

answer: @entity2


abstract: UNASSIGNED: Stem cell products derived from mesenchymal stem cells (MSCs) have been widely used in clinical trials, and a few products have been already commercialized. However, the therapeutic effects of clinical-grade MSCs are still controversial owing to mixed results from recent clinical trials. A potential solution to overcome this hurdle may be to use clonal stem cells as the starting cell material to increase the homogeneity of the final stem cell products. We have previously developed an alternative isolation and culture protocol for establishing a population of clonal MSCs (cMSCs) from single colony forming unit (CFU)-derived colonies. In this study, we established a good manufacturing practice (GMP)-compatible procedure for the clinical-grade production of @entity0 bone marrow-derived cMSCs based on the subfractionation culturing method. We optimized the culture procedures to expand and obtain a clonal population of final MSC products from single CFU-derived colonies in a GMP facility. The characterization results of the final cMSC products met our preset criteria. Animal @entity2 tests were performed in a good laboratory practice facility, and showed no @entity2 or @entity1 formation in vivo. These tests include single injection @entity2 , multiple injection @entity2 , biodistribution analysis, and tumorigenicity tests in vivo. No @entity4 were detected by in situ karyotyping using oligo-fluorescence in situ hydridization (oligo-FISH), providing evidence of genetic stability of the clinical-grade cMSC products. The manufacture and quality control results indicated that our GMP methodology could produce sufficient clonal population of MSC products from a small amount of @entity3 to treat a number of @entity0 .

title: Manufacture of Clinical-Grade XXXX Clonal Mesenchymal Stem Cell Products from Single Colony Forming Unit-Derived Colonies Based on the Subfractionation Culturing Method.

answer: @entity0


abstract: BACKGROUND: Influenza is a major public health problem worldwide; however, relatively little is known about @entity2 in tropical regions, especially for @entity0 . Additional information is required to inform public health policy making, in particular vaccination guidelines. METHODS: Between September 2011 and July 2013, we enrolled newborns into the Nicaraguan Birth Cohort Study. @entity0 were provided primary medical care and actively followed for reverse-transcription polymerase chain reaction-confirmed @entity3 when presenting with @entity2 or undifferentiated fever. This report presents data pertaining to the first year of life. RESULTS: Of the 518 @entity0 enrolled in the study, 441 participated throughout their first year of life, 71 were withdrawn, and 6 died. Overall, 13% of the @entity0 experienced at least 1 laboratory-confirmed @entity3 . The overall incidence of @entity2 was 15.5 cases per 100 @entity0 -years [95% confidence interval (CI): 12.2-19.5]. @entity0 aged 6-11 months experienced significantly higher rates of laboratory-confirmed @entity2 than @entity0 aged 0-5 months (incidence rate ratio: 2.1; 95% CI: 1.3-3.4). The overall incidence of @entity1 was 52.6 cases per 100 @entity0 -years (95% CI: 46.3-59.6). Three percent of the @entity1 cases were @entity2 associated, and the incidence of @entity2 -associated @entity1 and hospitalization was 1.7 (95% CI: 0.9-3.5) and 0.22 (95% CI: 0.03-1.55) cases per 100 @entity0 -years, respectively. CONCLUSIONS: We found a significant burden of @entity2 and @entity2 -associated severe respiratory outcomes in @entity0 . Our results support the need to explore the potential value of vaccinating pregnant @entity0 and @entity0 aged >6 months, as recommended by the World Health Organization in 2012.

title: Burden of Influenza and Influenza-associated XXXX in the First Year of Life in a Prospective Cohort Study in Managua, Nicaragua.

answer: @entity1


abstract: PURPOSE: To investigate the association between maternal reproductive age and their @entity0 ' @entity2 in Chinese urban students. METHODS: The Beijing Myopia Progression Study was a three-year cohort investigation. Cycloplegic refraction of these students at both baseline and follow-up vision examinations, as well as non-cycloplegic refraction of their parents at baseline, were performed. Student's refractive change was defined as the cycloplegic spherical equivalent (SE) of the right eye at the final follow-up minus the cycloplegic SE of the right eye at baseline. RESULTS: At the final follow-up, 241 students (62.4%) were reexamined. 226 students (58.5%) with completed refractive data, as well as completed parental reproductive age data, were enrolled. The average paternal and maternal age increased from 29.4 years and 27.5 years in 1993-1994 to 32.6 years and 29.2 years in 2003-2004, respectively. In the multivariate analysis, students who were younger (b = 0.08 diopter/year/year, P<0.001), with more myopic refraction at baseline (b = 0.02 diopter/year/diopter, P = 0.01), and with older maternal reproductive age (b = -0.18 diopter/year/decade, P = 0.01), had more myopic refractive change. After stratifying the parental reproductive age into quartile groups, @entity0 with older maternal reproductive age (trend test: P = 0.04) had more myopic refractive change, after adjusting for the @entity0 's age, baseline refraction, maternal refraction, and near work time. However, no significant association between myopic refractive change and paternal reproductive age was found. CONCLUSIONS: In this cohort, @entity0 with older maternal reproductive age had more myopic refractive change. This new risk factor for @entity1 progression may partially explain the faster myopic progression found in the Chinese population in recent decades.

title: The Association between Maternal Reproductive Age and Progression of XXXX in Urban Students in Beijing.

answer: @entity2


abstract: In HL-60 cells, @entity3 (RA) and 9 cis-RA induce granulocytic differentiation, and @entity4 and @entity7 induce monocytic differentiation. To study the role of @entity0 resistance on the response to these agents, we investigated their effects in HL-60 cells, @entity0 -resistant HL-60R cells, and HL-60R+ cells in which @entity0 sensitivity has been restored. In HL-60 cells, @entity6 (ctsd) mRNA levels are increased by these agents and by cholera toxin after pretreatment with each agent. @entity4 , 9 cis-RA, and @entity7 increase @entity1 ( @entity1 ) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of @entity1 by @entity5 ( @entity2 ). Pretreatment of HL-60 cells with all of the agents confers inducibility of @entity8 (ctsl) mRNA by TPA in previously unresponsive cells. In HL-60R cells, none of the agents alone or in combination significantly enhances the expression of the ctsd, @entity1 , or ctsl mRNAs. @entity0 stimulation (either alone or in combination with the other agents) of the three mRNAs is partially restored in the HL-60R+ cells. @entity4 does not alter the expression of any of these mRNAs, and only the stimulation of @entity1 mRNA by @entity7 is recovered. Treatment with all of the agents inhibits proliferation and stimulates differentiation of the HL-60 cells. RA and @entity4 are unable to inhibit proliferation of the HL-60R cells, whereas only @entity4 fails to inhibit proliferation of the HL-60R+ cells. None of the agents induces differentiation in either the HL-60R or HL-60R+ cells. Therefore, the mutation of the RA receptor alpha is insufficient to account for the altered responses of the HL-60R cells, and there are likely defects in other signaling pathways in these cells. These cells may prove useful in examining the mechanism of cross-resistance between various differentiating agents.

title: Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to @entity3 , XXXX , 9 cis-retinoic acid, and @entity7 .

answer: @entity4