abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity0 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity3 PET tracers frequently used in the clinic, @entity6 , @entity8 , and @entity9 , in a preclinical @entity0 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity0 ( @entity0 ), spatial reproducibility, and sensitivity to @entity1 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity4 R1-bearing WAG/Rij @entity2 were acquired at multiple time points post injection (p.i.) with one of the @entity3 tracers. @entity0 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity1 modifications were induced by exposure to either @entity7 / @entity5 treatment or 7% @entity1 breathing. RESULTS: @entity0 was stabilized and maximal at 2 hours p.i. for @entity8 (4.0    0.5) and at 3 hours p.i. for @entity9 (7.2    0.7), whereas @entity6 showed a constant increasing @entity0 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity6 (R = 0.86; Dice coefficient = 0.76) and @entity9 (R = 0.76; Dice coefficient = 0.70), whereas @entity8 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity3 fraction resulted in enhanced mean standardized uptake values for both @entity9 and @entity8 upon 7% @entity1 breathing. Only @entity6 uptake was found to be reversible upon exposure to @entity5 and @entity7 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the @entity3 PET Tracers @entity9 , @entity8 , and XXXX in a Preclinical Tumor Model.

answer: @entity6


abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity0 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity3 PET tracers frequently used in the clinic, @entity6 , @entity8 , and @entity9 , in a preclinical @entity0 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity0 ( @entity0 ), spatial reproducibility, and sensitivity to @entity1 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity4 R1-bearing WAG/Rij @entity2 were acquired at multiple time points post injection (p.i.) with one of the @entity3 tracers. @entity0 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity1 modifications were induced by exposure to either @entity7 / @entity5 treatment or 7% @entity1 breathing. RESULTS: @entity0 was stabilized and maximal at 2 hours p.i. for @entity8 (4.0    0.5) and at 3 hours p.i. for @entity9 (7.2    0.7), whereas @entity6 showed a constant increasing @entity0 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity6 (R = 0.86; Dice coefficient = 0.76) and @entity9 (R = 0.76; Dice coefficient = 0.70), whereas @entity8 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity3 fraction resulted in enhanced mean standardized uptake values for both @entity9 and @entity8 upon 7% @entity1 breathing. Only @entity6 uptake was found to be reversible upon exposure to @entity5 and @entity7 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the @entity3 PET Tracers @entity9 , XXXX , and @entity6 in a Preclinical Tumor Model.

answer: @entity8


abstract: BACKGROUND: The choroid plexuses (CPs) are brain structures located in the brain ventricles, involved in the production and reabsorption of cerebrospinal fluid (CSF) components, cerebral immune surveillance, and various endocrine-enzymatic activities and acts as a  CSF-blood barrier. This study investigated to determine if there is a  link between @entity0 and meningo-cerebral inflammation processes. MATERIAL AND METHODS: This study was conducted on 18 @entity2 . Four @entity2 were used as the baseline group to examine the normal structures. Fourteen of the @entity2 were used as the study group by injecting 1.00cc of homologous blood into their cisterna magna. The animals were followed by daily monitoring for ten days and then slaughtered. Apoptotic degeneration of the @entity12 cells was determined and statistical analyses were carried out using normal and apoptotic @entity12 cell numbers. Data analyses were comprised of Mann-Whitney U  tests. Differences were considered to be significant if p  <  0.005. RESULTS: Five animals belonging to the study group died between the 5th and 8th days. Unconsciousness, neck stiffness, @entity5 , @entity3 , @entity4 , @entity9 , and breathing disturbances were observed in all of the animals who subsequently died. Intraventricular blood leakage was detected in all the dead and three surviving animals. @entity11 , @entity13 , @entity1 , pia-arachnoid thickening, @entity10 and blood cell density in the subarachnoid spaces were more severe in the more @entity8 animals than those of the others. There were significant differences between the apoptotic @entity12 cell density and blood cell density in the subarachnoid spaces (p  <  0.005). CONCLUSIONS: @entity7 ( @entity7 ) extending to brain ventricles causes @entity0 by way of triggered @entity6 . It should be emphasized that the prevention of @entity12 function may be an important part of the protection of the brain in @entity7 .

title: Parallel development of choroid plexus degeneration and meningeal inflammation in XXXX - experimental study.

answer: @entity7


abstract: Dynamic testing includes procedures that examine the effects of brief training on test performance where pre- to post-training change reflects @entity0 ' learning potential. The objective of this systematic review was to provide clinicians and researchers insight into the concept and methodology of dynamic testing and to explore its predictive validity in adult @entity0 with @entity1 . The following electronic databases were searched: PubMed, PsychINFO, and Embase/Medline. Of 1141 potentially relevant articles, 24 studies met the inclusion criteria. The mean methodological quality score was 4.6 of 8. Eleven different dynamic tests were used. The majority of studies used dynamic versions of the Wisconsin Card Sorting Test. The training mostly consisted of a combination of performance feedback, reinforcement, expanded instruction, or strategy training. Learning potential was quantified using numerical (post-test score, difference score, gain score, regression residuals) and categorical (groups) indices. In five of six longitudinal studies, learning potential significantly predicted rehabilitation outcome. Three of four studies supported the added value of dynamic testing over conventional testing in predicting rehabilitation outcome. This review provides preliminary support that dynamic tests can provide a valuable addition to conventional tests to assess @entity0 ' abilities. Although promising, there was a large variability in methods used for dynamic testing and, therefore, it remains unclear which dynamic testing methods are most appropriate for @entity0 with @entity1 . More research is warranted to further evaluate and refine dynamic testing methodology and to further elucidate its predictive validity concerning rehabilitation outcomes relative to other cognitive and functional status indices.

title: Dynamic testing of learning potential in adults with XXXX : A systematic review of methodology and predictive value.

answer: @entity1


abstract: BACKGROUND: @entity3 has several clinical presentations and is caused by various infectious organisms. OBJECTIVE: To provide guidance for selection of appropriate treatment. METHODS: The literature on @entity3 management was reviewed to generate an evidence-based decision tree. RESULTS AND CONCLUSION: Several options are available: @entity5 , @entity1 , @entity2 , @entity6 8% nail lacquer, @entity7 10% nail solution, and laser therapy. Further studies on lasers are needed before use can be recommended. Nondermatophyte molds or @entity0 can be managed with @entity5 or @entity1 with or without topicals. @entity1 , @entity2 , and @entity7 can be used for @entity4 . For dermatophytes, topicals can be considered for mild to moderate @entity3 . For moderate to severe cases, any oral monotherapy can be used; however, we suggest @entity5 if there is a possibility of a drug interaction. These recommendations can be applied for all ages, immune function, or metabolic status, but proper monitoring and contraindications should be taken into consideration.

title: Management of XXXX in Canada in 2014.

answer: @entity3


abstract: @entity1 can occur in the postoperative period of @entity6 repair, @entity2 being the pathogenic factor most likely to be involved. This study was designed to evaluate the extent of the hemodynamic changes proximal and distal to the @entity6 at the time of cross-clamping, as well as the effects of @entity8 and @entity7 upon the hemodynamic changes. Included in the study were 17 @entity0 with adult type coarctations who had dual hemodynamic monitoring. During cross-clamping, there was an increase in the gradient between proximal and distal pressures, with severe @entity5 (< 50 mm Hg) occurring in six @entity0 . @entity7 corrected the @entity5 in five @entity0 , but the sixth required a surgical shunt. @entity8 was effective for the treatment of proximal @entity3 ; however, it also decreased distal pressure. The ligation of collateral vessels was associated with a decrease in distal pressures as well. During cross-clamping, pentolinium was useful for the management of proximal @entity3 and @entity7 increased the distal pressures in some of the @entity0 who presented @entity5 . However, because of the difficulties in predicting the individual response, their administration would be best guided by dual pressure monitoring. It is postulated that the recognition and proper treatment of @entity5 may be an important factor in the prophylaxis of @entity4 .

title: Technical and pharmacologic management of @entity5 during repair of XXXX .

answer: @entity6


abstract: @entity1 can occur in the postoperative period of @entity6 repair, @entity2 being the pathogenic factor most likely to be involved. This study was designed to evaluate the extent of the hemodynamic changes proximal and distal to the @entity6 at the time of cross-clamping, as well as the effects of @entity8 and @entity7 upon the hemodynamic changes. Included in the study were 17 @entity0 with adult type coarctations who had dual hemodynamic monitoring. During cross-clamping, there was an increase in the gradient between proximal and distal pressures, with severe @entity5 (< 50 mm Hg) occurring in six @entity0 . @entity7 corrected the @entity5 in five @entity0 , but the sixth required a surgical shunt. @entity8 was effective for the treatment of proximal @entity3 ; however, it also decreased distal pressure. The ligation of collateral vessels was associated with a decrease in distal pressures as well. During cross-clamping, pentolinium was useful for the management of proximal @entity3 and @entity7 increased the distal pressures in some of the @entity0 who presented @entity5 . However, because of the difficulties in predicting the individual response, their administration would be best guided by dual pressure monitoring. It is postulated that the recognition and proper treatment of @entity5 may be an important factor in the prophylaxis of @entity4 .

title: Technical and pharmacologic management of XXXX during repair of @entity6 .

answer: @entity5


abstract: Changes of bone during pregnancy and during lactation evaluated by @entity1 ( @entity1 ) may have implications for risk of @entity2 and @entity3 . We studied @entity1 in @entity0 of differing ages, parity, and lactation histories immediately postpartum for @entity1 , T-scores, and Z-scores. Institutional Review Board approval was received. All @entity0 while still in hospital postpartum were asked to participate. @entity1 was performed by dual-energy X-ray absorptiometry (DXA) machine at femoral neck (FN) and @entity4 ( @entity4 ) by a single technician. Of 132 @entity0 , 73 (55.3%) were  <=30 years; 27 (20.5%) were primiparous; 36 (27.3%) were grand multiparous; 35 (26.5%) never breast fed. Mean FN T-scores and Z-scores were higher than respective mean @entity4 scores, but all means were within the normal limits. Mean @entity4 T-scores and Z-scores were highest in the grand multiparas. There were only 2 (1.5%) outliers with low Z-scores. We conclude that, in a large cohort of Israeli @entity0 with @entity1 parameters assessed by DXA within two days postpartum, mean T-scores and Z-scores at both the @entity4 and FN were within normal limits regardless of age (20-46 years), parity (1-13 viable births), and history of either no or prolonged months of lactation (up to 11.25 years).

title: Bone mineral density in gravida: effect of pregnancies and breast-feeding in XXXX of differing ages and parity.

answer: @entity0


abstract: @entity3 Society-sponsored Unified @entity2 Rating Scale (MDS-UPDRS) has separate items for measuring @entity1 (item 1.7) and @entity1 (1.8). The aim of our study was to evaluate the screening sensitivity and specificity of these items to the @entity4 Sleep Scale 2nd version (PDSS-2) and Epworth Sleepiness Scale (ESS). In this nationwide, cross-sectional study 460 @entity4 @entity0 were enrolled. Spearman's rank correlation coefficients were calculated between the individual items, domains, and the total score of PDSS-2 and item 1.7 of MDS-UPDRS. Similarly, the items and the total score of ESS were contrasted to item 1.8 of MDS-UPDRS. After developing generalized ordinal logistic regression models, the transformed and observed scores were compared by Lin's Concordance Correlation Coefficient. Only item 3 difficulties staying asleep and the "disturbed sleep" domain of PDSS-2 showed high correlation with " @entity1 " item 1.7 of the MDS-UPDRS. Total score of PDSS-2 had moderate correlation with this MDS-UPRDS item. The total score of ESS showed the strongest, but still moderate, correlation with " @entity1 " item 1.8 of MDS-UPDRS. As intended, the MDS-UPDRS serves as an effective screening tool for both @entity1 and @entity1 and identifies subjects whose disabilities need further investigation.

title: Is the MDS-UPDRS a Good Screening Tool for Detecting Sleep Problems and Daytime Sleepiness in XXXX ?

answer: @entity2


abstract: Recent research has confirmed that between 25% and 33% of all hospitalized @entity0 experience unacceptable levels of @entity3 . Studies further indicate that this reduces @entity0 satisfaction levels, lengthens hospital stays, and increases cost. Hospitals are aiming to discharge @entity0 earlier, and this can interfere with adequate @entity3 management. Therefore, the @entity3 service at Chelsea and Westminster Hospital has adapted to this changing model of care. An increasing body of evidence demonstrates that psychological factors are key components of @entity0 ' @entity3 experiences in both acute and @entity4 . Therefore, it is reasonable to suggest a clinical psychologist should be involved in @entity3 management. This small study discusses three cases that highlight how @entity0 care could be improved by including a clinical psychologist as part of the @entity3 team. Two cases particularly highlight the active role of the psychologist in the diagnosis and management of common conditions such as fear and @entity2 , along with other @entity1 comorbidities. The management therefore employed an eclectic approach adapted from @entity4 and comprising of behavioral, cognitive behavioral, and dialectical behavioral therapeutic techniques blended with brief counseling. The third case exemplifies the importance of nurse- @entity0 interactions and the quality of nurse- @entity0 relationships on @entity0 outcomes. Here, the psychologist helped to optimize communication and to resolve a difficult and potentially risk-laden situation. This small case series discusses the benefits derived from the involvement of a clinical psychologist in the management of @entity3 , and therefore illustrates the need for novel initiatives for @entity3 services. However, future research is warranted to validate this approach.

title: The clinical psychologist and the management of XXXX : a small case series.

answer: @entity3


abstract: The cognitive model of reading comprehension (RC) posits that RC is a result of the interaction between decoding and linguistic comprehension. Recently, the notion of decoding skill was expanded to include word recognition. In addition, some studies suggest that other skills could be integrated into this model, like processing speed, and have consistently indicated that this skill influences and is an important predictor of the main components of the model, such as vocabulary for comprehension and phonological awareness of word recognition. The following study evaluated the components of the RC model and predictive skills in @entity0 and adolescents with @entity1 . 40 @entity0 and adolescents (8-13 years) were divided in a Dyslexic Group (DG; 18 @entity0 , MA = 10.78, SD = 1.66) and control group (CG 22 @entity0 , MA = 10.59, SD = 1.86). All were students from the 2nd to 8th grade of elementary school and groups were equivalent in school grade, age, gender, and IQ. Oral and RC, word recognition, processing speed, picture naming, receptive vocabulary, and phonological awareness were assessed. There were no group differences regarding the accuracy in oral and RC, phonological awareness, naming, and vocabulary scores. DG performed worse than the CG in word recognition (general score and orthographic confusion items) and were slower in naming. Results corroborated the literature regarding word recognition and processing speed deficits in @entity1 . However, dyslexics can achieve normal scores on RC test. Data supports the importance of delimitation of different reading strategies embedded in the word recognition component. The role of processing speed in reading problems remain unclear.

title: Reading component skills in XXXX : word recognition, comprehension and processing speed.

answer: @entity1


abstract: In @entity2 ( @entity2 ), thoracic range of motion is often greatly limited. The objective of the study was to describe the effects of 12 weeks of Glossopharyngeal Insufflation (GI) training in @entity0 with @entity2 . Dynamic spirometry included vital capacity, forced expiratory volume, and peak expiratory flow. @entity1 and lumbar range of motion was assessed by tragus-to-wall distance, modified Schober test, and tape measure. Disease activity, activity limitation, and health perception were assessed using the BAS-Indices, and @entity3 in the thoracic region during GI was assessed using the Borg CR-10 scale. Adherence to training was recorded in an activity log, along with any remarks on the training. Ten @entity0 were recruited and six male @entity0 fulfilled the study protocol. Three @entity0 were able to learn GI by exceeding their maximal vital capacity with 5% using GI. A significant increase in thoracic range of motion both on costae IV (P = 0.04) and at the level of the xiphoid process (P = 0.04) was seen. Thus, @entity0 with @entity2 can practice GI, it is safe if maximal exertion is avoided, and @entity0 with some mobility in the chest can increase their lung function substantially by performing GI during 12 weeks.

title: Effects of glossopharyngeal insufflation in XXXX : a pilot study.

answer: @entity2


abstract: OBJECTIVES: @entity0 with @entity2 ( @entity2 ) have a high risk of @entity1 ( @entity1 ). Recent national and international guidelines suggest strict treatment of @entity1 risk factors in @entity2 . The aim of this study was to evaluate the self-reported adherence to CV prevention strategies in @entity0 with @entity2 . METHOD: @entity2 @entity0 visiting an outpatient clinic for strict @entity1 risk management received a validated questionnaire to evaluate adherence to CV prevention strategies. Strict treatment targets were defined and lifestyle recommendations were given following a prespecified protocol. @entity1 risk was assessed using the SCORE algorithm. RESULTS: In total, 111 questionnaires were returned (response rate of 82%). A high 10-year @entity1 risk (>=  20%) was present in 53%, but only 3% thought they had an increased @entity1 risk. A total of 53% of @entity0 reported that they 'follow the doctors' suggestions exactly' and 75% reported finding it 'easy to follow the suggestions'. Of the 69% of @entity0 who were prescribed lipid- and/or blood pressure-lowering drugs, 90% reported taking all prescribed tablets. The advice to follow a diet was given to 42%, of whom 68% said they followed the advised diet. Physical exercise was advised to 67%, of whom 62% said they performed specific physical exercise on at least 3 days a week. The adherence to lifestyle recommendations was not significantly different across the @entity1 risk groups. CONCLUSIONS: @entity2 @entity0 tend to underestimate their @entity1 risk. The self-reported adherence of @entity2 @entity0 to @entity1 risk management was high concerning pharmaceutical interventions and moderate in the case of lifestyle interventions.

title: Adherence to cardiovascular prevention strategies in @entity0 with XXXX .

answer: @entity2


abstract: OBJECTIVES: @entity0 with @entity2 ( @entity2 ) have a high risk of @entity1 ( @entity1 ). Recent national and international guidelines suggest strict treatment of @entity1 risk factors in @entity2 . The aim of this study was to evaluate the self-reported adherence to CV prevention strategies in @entity0 with @entity2 . METHOD: @entity2 @entity0 visiting an outpatient clinic for strict @entity1 risk management received a validated questionnaire to evaluate adherence to CV prevention strategies. Strict treatment targets were defined and lifestyle recommendations were given following a prespecified protocol. @entity1 risk was assessed using the SCORE algorithm. RESULTS: In total, 111 questionnaires were returned (response rate of 82%). A high 10-year @entity1 risk (>=  20%) was present in 53%, but only 3% thought they had an increased @entity1 risk. A total of 53% of @entity0 reported that they 'follow the doctors' suggestions exactly' and 75% reported finding it 'easy to follow the suggestions'. Of the 69% of @entity0 who were prescribed lipid- and/or blood pressure-lowering drugs, 90% reported taking all prescribed tablets. The advice to follow a diet was given to 42%, of whom 68% said they followed the advised diet. Physical exercise was advised to 67%, of whom 62% said they performed specific physical exercise on at least 3 days a week. The adherence to lifestyle recommendations was not significantly different across the @entity1 risk groups. CONCLUSIONS: @entity2 @entity0 tend to underestimate their @entity1 risk. The self-reported adherence of @entity2 @entity0 to @entity1 risk management was high concerning pharmaceutical interventions and moderate in the case of lifestyle interventions.

title: Adherence to cardiovascular prevention strategies in XXXX with @entity2 .

answer: @entity0


abstract: Background. Only some studies provide sufficient data regarding the effects of nonpostbariatric (aesthetic) abdominoplasty on various aspects of quality of life. Nevertheless, when considering the effects on eating habits, publications are lacking. Therefore we decided to assess the effects of nonpostbariatric abdominoplasty on @entity3 symptoms, @entity2 , and quality of life. Materials and Methods. 64 consecutive @entity0 underwent nonpostbariatric abdominoplasty. Three outcome measures were completed: the @entity3 Inventory (EDI), Raitasalo's modification of the Beck Depression Inventory (RBDI), and the 15D general quality of life questionnaire. Results. The mean age at baseline was 42 years and the mean body mass index (BMI) 26.4. Fifty-three (83%) @entity0 completed all the outcome measures with a mean follow-up time of 5 months. A significant improvement from baseline to follow-up was noted in @entity0 's overall quality of life, body satisfaction, effectiveness, sexual functioning, and self-esteem. The @entity0 were significantly less @entity1 and had significantly less drive for thinness as well as @entity4 , and their overall risk of developing an @entity3 also decreased significantly. Conclusions. Abdominoplasty results in significantly improved quality of life, body satisfaction, effectiveness, sexual functioning, self-esteem, and mental health. The risk of developing an @entity3 is decreased significantly. This trial is registered with Clinicaltrials.gov NCT02151799.

title: Abdominoplasty improves quality of life, @entity2 , and XXXX symptoms: a prospective study.

answer: @entity3


abstract: Background. Only some studies provide sufficient data regarding the effects of nonpostbariatric (aesthetic) abdominoplasty on various aspects of quality of life. Nevertheless, when considering the effects on eating habits, publications are lacking. Therefore we decided to assess the effects of nonpostbariatric abdominoplasty on @entity3 symptoms, @entity2 , and quality of life. Materials and Methods. 64 consecutive @entity0 underwent nonpostbariatric abdominoplasty. Three outcome measures were completed: the @entity3 Inventory (EDI), Raitasalo's modification of the Beck Depression Inventory (RBDI), and the 15D general quality of life questionnaire. Results. The mean age at baseline was 42 years and the mean body mass index (BMI) 26.4. Fifty-three (83%) @entity0 completed all the outcome measures with a mean follow-up time of 5 months. A significant improvement from baseline to follow-up was noted in @entity0 's overall quality of life, body satisfaction, effectiveness, sexual functioning, and self-esteem. The @entity0 were significantly less @entity1 and had significantly less drive for thinness as well as @entity4 , and their overall risk of developing an @entity3 also decreased significantly. Conclusions. Abdominoplasty results in significantly improved quality of life, body satisfaction, effectiveness, sexual functioning, self-esteem, and mental health. The risk of developing an @entity3 is decreased significantly. This trial is registered with Clinicaltrials.gov NCT02151799.

title: Abdominoplasty improves quality of life, XXXX , and @entity3 symptoms: a prospective study.

answer: @entity2


abstract: UNASSIGNED: The two main manifestations of @entity2 that require surgery are @entity4 associated with @entity5 (TBMH) and @entity1 . TBMH most often responds to medical therapy but surgery is required promptly for those who fail medical therapy. Both ventriculoperitoneal (VP) shunt and endoscopic third ventriculostomy (ETV) are valid options although the latter is more often successful in @entity0 with chronic @entity4 than in those with acute @entity3 . @entity0 with TBMH are more prone to complications following VP shunt than other @entity0 . The outcome of these @entity0 is determined by the Vellore grade (I to IV) of the @entity0 prior to surgery with those in good grades (I and II) having a better outcome and those in the worst grade (IV) having a high mortality in excess of 80  %. @entity0 with @entity1 present clinically with features of a @entity1 , indistinguishable clinically from other pathologies. CT and MR features might provide a probable diagnosis of a @entity6 but most often a histological diagnosis is desirable. Empiric medical therapy is reserved for a small number of @entity0 . Although the treatment of @entity1 is essentially medical, surgery is required when the diagnosis is in doubt, to reduce raised intracranial pressure or local mass effect and to obtain tissue for culture and sensitivity studies. Stereotactic biopsy, stereotactic craniotomy and excision of superficial small @entity6 and microsurgery are all procedures used to manage @entity1 . The outcome in @entity0 with @entity1 is good if the tuberculous bacillus is sensitive to the anti-tuberculous therapy. The duration of therapy is debated but we suggest at least 18  months of combination therapy with three or four anti-tuberculous drugs and continue the therapy till the @entity6 has resolved on neuro-imaging.

title: Surgery for XXXX : a review.

answer: @entity2


abstract: Bulgarian statistics of recent years (2008-2012) indicate weak knowledge and use of the various screenings . Low percentage of pregnant passed screening tests and improper interpretation of the calculated risks, has led on the one hand to the high percentage of invasive diagnostics in the surveyed population (6% instead of 3%) to diagnose 90% of pregnancies with trisomy 21, and at the same time low percentage diagnosed pregnancies with @entity3 in the population of all pregnant @entity0 (tested and untested). We are performing invasive procedures of almost all pregnant @entity0 over 35 years old, and instead of the screening in the 1st trimester, we still use the screening in the 2nd trimester which is with limited application in Europe because of the high rate of false positive (false positive rate) and the unsatisfactory rate of recognized pregnancies with chromosomal defects (detedtion rate 70%). OBJECTIVE: To make the analysis of screening data, in the 1st and 2nd trimester for the period 2008-2012 in the Hospital "Maichin Dom" and our Center for Prenatal Diagnosis (respectively 93956 and 5046 pregnant @entity0 observed), the percentage of invasive diagnostic and percent diagnosed with Down syndr. in the total number of pregnancies, 99002 versus the number born with the disease in the country according to data of the National Statistical Institute. METHODS AND MATERIALS Used was the algorytm of @entity2 London to assess the effectiveness of the various screenings (Prof Nikolaides et al.) more specific for each of them - Detection rate and False positive rate, and statistical meta-analyses of H. Cuckle and D. Wright, for the estimated number of pregnancies with Down syndr.and the expected percentage of invasive diagnostics for locating over 90% of them in a population of 100,000 pregnant @entity0 . RESULTS: 99002 Surveyed pregnancies for the period 2008-2012 are around 25% of the total population (377,040 births), there are 7645 invasive procedures (i.e. 7,7 % of the expected 3%) and are diagnosed with @entity3 pregnancies were 181 from statistically expected about 200 (i.e., 90%) in the same period, 152 babies are born with TRI 21. CONCLUSIONS: In terms of the lack of a National Strategy for screening for @entity1 , non-compliance with the principles and protocols for consultation of @entity0 about the results obtained and generally poor knowledge of the various screenings have led to the negative attitude of the doctors and @entity0 to screening programs and low percentage of pregnant @entity0 targeted or seeking such tests (about 30%) and a high percentage of invasive diagnosis (due to the high percentage of false positive rate and incorrect interpretation of the calculated risks).

title: [Types of screening for XXXX - results in Bulgaria, conclusions and future objectives].

answer: @entity1


abstract: INTRODUCTION: Permanent @entity1 ( @entity1 ) remains an essential goal of ablation therapy in @entity0 with @entity4 . Aim of this study was the intra-individual comparison of unexcitability to pacing along the ablation line vs. dormant conduction (DC) as additional procedural endpoints. METHODS: A total of 58 @entity0 with @entity4 ( @entity4 ) underwent @entity1 by circumferential ablation of ipsilateral pulmonary veins (PVs), followed by testing for DC by @entity2 administration. Irrespective of the presence of DC, pacing along the ablation line for left atrium capture was performed and additional radio frequency (RF) energy applied if necessary. PVs with initial DC were re-tested after achieving unexcitability. RESULTS: @entity1 was achieved in 224 of 224 PVs. In 33 of 224 PVs (15%) DC was revealed. At 92 of 112 ablation lines (82%) sites of excitability were found. Three (9%) of the initial 33 PVs with DC showed further DC after achieving unexcitability at repeated testing. 32 of 33 assumed areas of unmasked @entity5 re-conduction as revealed by DC-testing showed a corresponding site of excitability on the ablation line. After a follow-up of 11.6  3.4 months 79% of @entity0 were free of @entity3 . CONCLUSIONS: Pacing for unexcitability can safely identify potential sites of DC and even sites that would have not been detected by testing for DC. Unexcitability therefore serves as a suitable and safe procedural endpoint not only for @entity0 with contraindications to @entity2 administration. Our data suggest that @entity2 may be expendable when achieving unexcitability along the ablation line. This article is protected by copyright. All rights reserved.

title: Loss of Pace Capture on the Ablation Line During Pulmonary Vein Isolation vs. "Dormant Conduction": Is XXXX Expendable?

answer: @entity2


abstract: OBJECTIVE: To perform a systematic review and meta-analysis to determine if isolated nasal surgery in @entity0 with @entity1 and nasal airway obstruction @entity1 . DATA SOURCES: Computerized searches were performed in PubMed, EMBASE, and the Cochrane Library through October 2014. Manual searches and subject matter expert input was also solicited. REVIEW METHODS: A search protocol was defined a priori, and 2 independent investigators performed the data extraction, focusing on relevant data, including quality data polysomnography data, and taking note of methodological quality and risk for bias. RESULTS: The 10 studies meeting criteria included a total of 320 @entity0 . There were 2 randomized controlled trials, 7 prospective studies, and 1 retrospective study. There was a significant improvement in the pooled results of both Epworth Sleepiness Scale (ESS; difference 3.53, 95% confidence interval [CI] [0.64, 6.23]) and Respiratory Disturbance Index (RDI; 11.06, 95% CI [5.92, 16.19]) scores with isolated nasal surgery. There was no significant improvement in the @entity1 ( @entity1 ) in the random effects model (4.83, 95% CI [-1.6, 11.62]). CONCLUSIONS: The pooled results showed that isolated nasal surgery for @entity0 with @entity1 improved some sleep parameters, as shown by significant improvements in ESS and RDI, but had no significant improvements on @entity1 . Future controlled studies with larger groups are needed to confirm the benefits of isolated nasal surgery in this @entity0 population.

title: Does Nasal Surgery Improve OSA in XXXX with Nasal Obstruction and OSA? A Meta-analysis.

answer: @entity0


abstract: UNASSIGNED: Schwann cells (SCs) hold promise for @entity1 ( @entity1 ) repair; however, there are limitations for its use as a lone treatment. We showed that acute inhibition of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) by @entity3 ( @entity2 ) was neuroprotective and enhanced function following cervical hemicontusion @entity1 . We hypothesized that combining acute @entity2 therapy and delayed SC engraftment would further improve neuroprotection and recovery after cervical @entity1 . Adult female Sprague-Dawley (SD) @entity0 were randomly sorted into 5 groups: sham, vehicle, @entity2 , SC transplantation, and @entity2 +SC transplantation. SCs were isolated from adult green fluorescent protein (GFP)-expressing SD @entity0 (GFP-SCs). 200 g/kg @entity2 (pic) was administered intraperitoneally (IP) twice daily for 7days post- @entity1 in @entity2 -treated groups. GFP-SCs (1*10(6) in 5 l medium) were transplanted into the lesion epicenter at the 8th day post- @entity1 . Forelimb function was tested for 10weeks and histology was assessed. @entity2 alone significantly reduced lesion (by 40%, p<0.05) and cavitation (by 65%, p<0.05) and improved functional recovery (p<0.05) compared to injury alone. The combination promoted similar neuroprotection (p<0.01 vs. injury); however, GFP-SCs alone did not. Both SC-transplanted groups exhibited remarkable long-term SC survival, SMI-31(+) axon ingrowth and RECA-1(+) vasculature presence in the SC graft; however, @entity2 +SCs promoted an 89% greater axon-to-lesion ratio than SCs only. We concluded that @entity2 likely contributed largely to the neuroprotective and functional benefits while SCs facilitated considerable host-tissue interaction and modification. The combination of the two shows promise as an attractive strategy to enhance recovery after @entity1 .

title: Biphasic XXXX administration and Schwann cell transplantation for repair after cervical contusive @entity1 .

answer: @entity3


abstract: UNASSIGNED: Schwann cells (SCs) hold promise for @entity1 ( @entity1 ) repair; however, there are limitations for its use as a lone treatment. We showed that acute inhibition of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) by @entity3 ( @entity2 ) was neuroprotective and enhanced function following cervical hemicontusion @entity1 . We hypothesized that combining acute @entity2 therapy and delayed SC engraftment would further improve neuroprotection and recovery after cervical @entity1 . Adult female Sprague-Dawley (SD) @entity0 were randomly sorted into 5 groups: sham, vehicle, @entity2 , SC transplantation, and @entity2 +SC transplantation. SCs were isolated from adult green fluorescent protein (GFP)-expressing SD @entity0 (GFP-SCs). 200 g/kg @entity2 (pic) was administered intraperitoneally (IP) twice daily for 7days post- @entity1 in @entity2 -treated groups. GFP-SCs (1*10(6) in 5 l medium) were transplanted into the lesion epicenter at the 8th day post- @entity1 . Forelimb function was tested for 10weeks and histology was assessed. @entity2 alone significantly reduced lesion (by 40%, p<0.05) and cavitation (by 65%, p<0.05) and improved functional recovery (p<0.05) compared to injury alone. The combination promoted similar neuroprotection (p<0.01 vs. injury); however, GFP-SCs alone did not. Both SC-transplanted groups exhibited remarkable long-term SC survival, SMI-31(+) axon ingrowth and RECA-1(+) vasculature presence in the SC graft; however, @entity2 +SCs promoted an 89% greater axon-to-lesion ratio than SCs only. We concluded that @entity2 likely contributed largely to the neuroprotective and functional benefits while SCs facilitated considerable host-tissue interaction and modification. The combination of the two shows promise as an attractive strategy to enhance recovery after @entity1 .

title: Biphasic @entity3 administration and Schwann cell transplantation for repair after cervical contusive XXXX .

answer: @entity1


abstract: UNASSIGNED: We report an unusual case of @entity3 wound of the cervical spinal cord, which illustrates the value of post-mortem computed tomography angiography (PMCTA) in cases of @entity1 . First, we noted a posterior and horizontal trajectory to the neck with complete section of the cervical spinal cord between the first and second cervical vertebrae. This lesion was accompanied by section of the right vertebral and right deep cervical arteries. We also noted an anterior cervical trajectory with an injury to the right internal jugular vein and an anterior right chest wound with a lung trajectory and section of the internal mammary vessels. Cases of @entity2 secondary to stab wounds are rare in the literature. Only one large series has been published from Cape Town. Complete section of the cervical spinal cord accounts for only 4.5% of all cases. Furthermore, lethal cases are rare and classically victims survive and present neurological sequelae. We found only one similar case but despite the transection of the cervical spinal cord the @entity0 survived. Some studies suggest that PMCTA may be very helpful in @entity1 . Our observations are consistent with this proposal. The use of different-time acquisitions was essential for detection of the injured vessels.

title: An unusual XXXX wound of the cervical spinal cord: A single case examined by post-mortem computed tomography angiography (PMCTA).

answer: @entity3


abstract: UNASSIGNED: Entanglement in fixed @entity1 gear is a conservation concern for whales worldwide, including in the United States where @entity0 of North Atlantic right and @entity3 have exceeded management limits for decades. We examined @entity1 gear removed from live and dead entangled whales along the US East Coast and the Canadian Maritimes from 1994-2010 to investigate rope polymer type, breaking strength, and diameter in relation to whale species, age, and injury severity. For the 132 retrieved ropes from 70 cases, average tested breaking strength was 2616 lbs (SD 1863; range 180-8910 lbs), which is 26% lower than strength at manufacture (mean 3530 SD 2224; range 650-12000 lbs). Median rope diameter was 3/8 inch. Right and @entity3 were found in ropes with significantly stronger breaking strengths at manufacture than @entity2 (4338 3850 and 2353 mean lbs, respectively). Adult right whales were found in stronger ropes (mean 7664 lbs) than juvenile right whales (mean 3446 lbs) and all @entity3 age classes (mean 3906 lbs). For right whales, injuries have become more severe over the past three decades, possibly due to changes in rope manufacturing in the mid 1990's that resulted in stronger ropes at the same diameter. Our results suggest that broad adoption of ropes with breaking strengths of 1700 lbs or less could reduce the number of life-threatening entanglements for large whales by at least 72%, and still be strong enough to withstand the routine forces involved in many @entity1 operations. A reduction of this magnitude would achieve nearly all of the mitigation legally required for US stocks of North Atlantic right and @entity3 . Reduced breaking strength ropes should be developed and tested to determine the feasibility of its use in a variety of fisheries. This article is protected by copyright. All rights reserved.

title: Implications of XXXX rope strength on the severity of large whale entanglements.

answer: @entity1


abstract: OBJECTIVE: This study determined the correlation between the levels of reactive @entity2 species (ROS) in prepared culture media and the early development of @entity0 embryos. MATERIALS AND METHODS: This was an autocontrolled comparison study. A total of 159 @entity0 undergoing in  vitro fertilization/intracytoplasmic sperm injection treatment were recruited in this study. The pH values, osmolarity pressures, and ROS levels of 15 batches of two culture media were measured. Sibling oocytes or embryos from individual @entity0 were randomly assigned to two culture groups with Quinn's Advantage Cleavage and Blastocyst media (QAC/QAB) or GIII series cleavage and blastocyst media (G1.3/G2.3). The difference between the two culture groups was analyzed using one-sample t test. RESULTS: The QAC/QAB and G1.3/G2.3 media exhibited similar pH values and osmolarity pressures. However, the prepared QAC/QAB media were characterized to contain lower amounts of ROS than the G1.3/G2.3 media. Furthermore, the blastocysts that developed under the QAC/QAB media were morphologically superior to those that developed under the G1.3/G2.3 media. CONCLUSION: The elevated ROS levels in culture media were associated with poor development of @entity1 . Measurement of ROS levels may be a valuable process for medium selection or modification.

title: Effects of reactive XXXX species levels in prepared culture media on embryo development: A comparison of two media.

answer: @entity2


abstract: OBJECTIVE: Use of vaginal meshes for treatment of @entity1 ( @entity1 ) remains controversial. A trend toward abdominal approaches and the development of new meshes has been noted. We compared the 1-year results of two different approaches using new lightweight meshes. MATERIALS AND METHODS: Sixty-nine (95.8%) of 72 @entity0 with @entity1 Stage  >=   2, who underwent laparoscopic sacrocolpopexy (LSC) (n  =  39) or a total vaginal mesh (TVM) procedure (n  =  30) using lightweight @entity2 meshes, were studied. Baseline and follow-up assessments included a pelvic examination and a composite condition-specific questionnaire. A detailed comparison of 1-year outcomes was made. Data were analyzed using appropriate statistical methods. RESULTS: Compared to the TVM group, the LSC group was characterized by a younger age (53.7 years vs. 64.1 years, p  <  0.001) and a longer operating time (264 minutes vs. 177.6 minutes, p  <  0.001). Objective anatomic success ( @entity1 Stage   <=  1) rates were similar between groups after statistical adjustment, i.e., 84.6% (33/39) and 86.7% (26/30) after LSC and TVM (p  =  0.94), respectively. However, the dominant recurrence sites were different with anterior (n  =  6) most frequent after LSC and apical (n  =  4) most frequent after TVM. Reoperations were needed for the four (13.3%) apical recurrences in the TVM group. No serious complications were noted. We found "cystocele as the dominant prolapse" (p  =  0.016; odds ratio  =  6.94) and "suspension of prolapsed ( @entity1 Stage  >=   2) uterus" (p  =  0.025; odds ratio  =  7.00) significantly affected recurrence after LSC and TVM, respectively. CONCLUSION: @entity1 repair by LSC or TVM using the new lightweight @entity2 meshes seems to be safe and has comparable outcomes, but limitations may vary.

title: A comparative study of laparoscopic sacrocolpopexy and total vaginal mesh procedure using lightweight XXXX meshes for prolapse repair.

answer: @entity2


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Hedyotis corymbosa (Linn.) Lam. is a small herb commonly called as khetpapra, traditionally used to treat a wide range of diseases including @entity4 , @entity5 and @entity1 . This study was conducted to evaluate the antinociceptive effect of @entity6 extract of Hedyotis corymbosa (EEHC) whole plant. MATERIALS AND METHODS: The antinociceptive activity of EEHC was evaluated in @entity0 using both chemical- and heat-induced @entity2 models such as @entity8 -induced writhing, hot plate, tail immersion, @entity3 , and @entity9 tests at 50, 100, and 200mg/kg doses. In order to verify the possible involvement of opioid receptors in the central antinociceptive effect of EEHC, the effects found in hot plate and tail immersion tests were antagonized with @entity7 . RESULTS: EEHC produced a dose-dependent antinociceptive effect against the chemical- and heat-induced @entity2 in @entity0 , significantly at 100 and 200mg/kg doses. These findings suggest that the action of EEHC involves both peripheral and central antinociceptive mechanisms. The antinociceptive activity of EEHC was significantly attenuated by pretreatment with @entity7 , indicating the influence of opioid receptors on the exertion of EEHC action centrally. CONCLUSIONS: This study reports the antinociceptive activity of Hedyotis corymbosa and possible underlying mechanism(s) that supports the traditional use of this plant in the treatment of different @entity2 .

title: Evaluation of antinociceptive effect of XXXX extract of Hedyotis corymbosa Linn. whole plant in @entity0 .

answer: @entity6


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Hedyotis corymbosa (Linn.) Lam. is a small herb commonly called as khetpapra, traditionally used to treat a wide range of diseases including @entity4 , @entity5 and @entity1 . This study was conducted to evaluate the antinociceptive effect of @entity6 extract of Hedyotis corymbosa (EEHC) whole plant. MATERIALS AND METHODS: The antinociceptive activity of EEHC was evaluated in @entity0 using both chemical- and heat-induced @entity2 models such as @entity8 -induced writhing, hot plate, tail immersion, @entity3 , and @entity9 tests at 50, 100, and 200mg/kg doses. In order to verify the possible involvement of opioid receptors in the central antinociceptive effect of EEHC, the effects found in hot plate and tail immersion tests were antagonized with @entity7 . RESULTS: EEHC produced a dose-dependent antinociceptive effect against the chemical- and heat-induced @entity2 in @entity0 , significantly at 100 and 200mg/kg doses. These findings suggest that the action of EEHC involves both peripheral and central antinociceptive mechanisms. The antinociceptive activity of EEHC was significantly attenuated by pretreatment with @entity7 , indicating the influence of opioid receptors on the exertion of EEHC action centrally. CONCLUSIONS: This study reports the antinociceptive activity of Hedyotis corymbosa and possible underlying mechanism(s) that supports the traditional use of this plant in the treatment of different @entity2 .

title: Evaluation of antinociceptive effect of @entity6 extract of Hedyotis corymbosa Linn. whole plant in XXXX .

answer: @entity0


abstract: BACKGROUND: @entity1 repair is one of the most performed surgeries in the world. It is recognized that any surgery of the pelvic floor may represent a risk factor of @entity4 . METHOD: Retrospective study of @entity0 with @entity3 and a history of adult @entity1 surgery and referred to our center between January 1990 and January 2011 for @entity2 . RESULTS: Among 69 @entity3 @entity0 with history of adult @entity1 surgery, 60 @entity0 underwent surgical extraction of sperm that was successful in 75% (45/60). Positive extraction rate decreases in the subgroup of @entity0 with risk factors for @entity2 (61.4%) as well as in the group with @entity1 (67.9%). There was no statistically significant difference in the positive rate of sperm retrieval according to surgical technique or according to the use of @entity5 mesh (P>0.05). CONCLUSION: The obstruction of the vas deferens due to an @entity1 was a potential iatrogenic cause of @entity4 that was rare and underestimated. The influence of using a @entity5 mesh was not clearly demonstrated. The management of these @entity0 is based on prevention in order to identify @entity0 with risk factors of @entity2 in order to propose a presurgery cryopreservation of sperm. LEVEL OF EVIDENCE: 5.

title: [ @entity3 and a history of XXXX in adult].

answer: @entity1


abstract: BACKGROUND: @entity1 repair is one of the most performed surgeries in the world. It is recognized that any surgery of the pelvic floor may represent a risk factor of @entity4 . METHOD: Retrospective study of @entity0 with @entity3 and a history of adult @entity1 surgery and referred to our center between January 1990 and January 2011 for @entity2 . RESULTS: Among 69 @entity3 @entity0 with history of adult @entity1 surgery, 60 @entity0 underwent surgical extraction of sperm that was successful in 75% (45/60). Positive extraction rate decreases in the subgroup of @entity0 with risk factors for @entity2 (61.4%) as well as in the group with @entity1 (67.9%). There was no statistically significant difference in the positive rate of sperm retrieval according to surgical technique or according to the use of @entity5 mesh (P>0.05). CONCLUSION: The obstruction of the vas deferens due to an @entity1 was a potential iatrogenic cause of @entity4 that was rare and underestimated. The influence of using a @entity5 mesh was not clearly demonstrated. The management of these @entity0 is based on prevention in order to identify @entity0 with risk factors of @entity2 in order to propose a presurgery cryopreservation of sperm. LEVEL OF EVIDENCE: 5.

title: [ XXXX and a history of @entity1 in adult].

answer: @entity3


abstract: UNASSIGNED: @entity9 ( @entity9 ) has a fatal complication of @entity6 ( @entity6 ) associated with @entity8 ( @entity8 ), i.e. @entity6 and @entity3 ( @entity3 ). Although @entity3 accounts for a small percentage of these @entity0 , it is difficult to make a differential diagnosis of this syndrome from @entity8 without @entity6 because the clinical presentations resemble each other. Furthermore, not only does the cause of @entity3 following @entity9 remain unclear but also the role of controlling postoperative blood pressure is not detected in preventing @entity6 after @entity9 . Herein, we report a case of @entity3 following @entity9 and review previous literature to discuss the mechanism and the management of this fatal complication. A 78-year-old @entity0 with a history of @entity7 and @entity4 was referred to our department for intervention to asymptomatic severe @entity5 of the right internal carotid artery. We performed @entity9 under local anesthesia. Although her blood pressure was controlled to normotension during the procedure, the @entity0 complained of @entity1 following predilation. Postoperative emergent non-contrast computed tomography revealed @entity3 with leakage of contrast medium occupying the right sylvian fissure. We continued strict blood pressure control, and the @entity0 was discharged without any @entity2 . A well-opened lumen of the stent was recognized three months later at the outpatient visit. Strict control of intraoperative and postoperative blood pressure may improve the outcome of @entity3 following @entity9 though the role in preventing @entity6 after @entity9 is unclear.

title: Intraoperative XXXX during carotid artery stenting: A case report and literature review.

answer: @entity3


abstract: OBJECTIVE: Little is known about the long-term intellectual outcomes following @entity1 . Change is not likely within the first 2  years following surgery, and the few studies of longer term outcomes have yielded inconsistent results. This study addressed this issue by examining a large group of surgical and non-surgical @entity0 at baseline and after 4-11  years. METHODS: @entity0 were 97 @entity0 (mean age 20.08 [SD: 4.44]  years) with childhood-onset intractable @entity1 ; 61 had undergone resective @entity1 surgery. @entity0 underwent neuropsychological testing with the age-appropriate Wechsler Intelligence Scale, generating Full Scale, Performance and Verbal IQs, and Working Memory and Processing Speed indices. RESULTS: In total 54% of the surgical and 39% of the non-surgical @entity0 were @entity2 free in the preceding 12  months (p  >  .05); however, surgical @entity0 did achieve @entity2 freedom sooner and used fewer medications at follow-up. Surgical status was not associated with any cognitive domain. However, with the exception of processing speed, significant @entity2 status  *  time interaction effects were evident and @entity2 -free @entity0 had higher scores at follow-up. Regression analyses additionally showed that low pre-operative scores were predictive of improvement overtime, whereas high pre-operative scores were predictive of high scores at follow-up. INTERPRETATION: The results show similar intellectual outcomes for surgical and non-surgical paediatric @entity0 . Four to 11  years after @entity1 , @entity2 freedom, whether attained through @entity1 surgery or other means, was found to be associated with intellectual improvements. @entity2 status and baseline scores were the most consistent predictors.

title: Development of intelligence 4 to 11  years after XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity5 agonists ( @entity4 RAs) are a new class of drugs that might have a potential beneficial effect on bone metabolism. Data on the effect of @entity4 RAs and @entity1 risk are lacking. The aim of the present study was to investigate the association between the use of @entity4 and the risk of @entity1 . A case-control study was performed using Danish National Health Service data. Cases were those who sustained a @entity1 and controls were those without a @entity1 during the study period (2007-2011), all aged 18  years and above. Conditional logistic regression estimated the odds ratios (OR) of @entity1 with current use of DPP4-I use. Analyses were adjusted for comorbidities and recent drug use. Among cases (n  =  229,114), there were 6993 current non-insulin anti- @entity0 drug (NIAD) users (excluding incretin users) and 255 @entity4 RA users. Similarly, among controls (n  =  229,114), 7209 were NIAD users (excluding incretin users) and 220 were @entity4 RA users. Current @entity4 RA use was not associated with a decreased risk of @entity1 [adjusted (adj.) OR 1.16; 95  % CI 0.83-1.63]. @entity3 risk was also not associated with current @entity4 RA use (adj. OR 0.78; 95  % CI 0.44-1.39). In our nation-wide case-control study, we identified that the use of @entity4 RA was not associated with @entity1 risk as compared to the use of other anti- @entity2 drugs. Additionally, current @entity4 RA use, stratified by cumulative or average daily dose, is not associated with @entity1 risk. Further research should focus on long-term use of @entity4 RA and @entity1 risk.

title: Use of Glucagon-Like-Peptide 1 Receptor Agonists and Risk of @entity1 as Compared to Use of Other Anti- XXXX Drugs.

answer: @entity2


abstract: UNASSIGNED: @entity5 agonists ( @entity4 RAs) are a new class of drugs that might have a potential beneficial effect on bone metabolism. Data on the effect of @entity4 RAs and @entity1 risk are lacking. The aim of the present study was to investigate the association between the use of @entity4 and the risk of @entity1 . A case-control study was performed using Danish National Health Service data. Cases were those who sustained a @entity1 and controls were those without a @entity1 during the study period (2007-2011), all aged 18  years and above. Conditional logistic regression estimated the odds ratios (OR) of @entity1 with current use of DPP4-I use. Analyses were adjusted for comorbidities and recent drug use. Among cases (n  =  229,114), there were 6993 current non-insulin anti- @entity0 drug (NIAD) users (excluding incretin users) and 255 @entity4 RA users. Similarly, among controls (n  =  229,114), 7209 were NIAD users (excluding incretin users) and 220 were @entity4 RA users. Current @entity4 RA use was not associated with a decreased risk of @entity1 [adjusted (adj.) OR 1.16; 95  % CI 0.83-1.63]. @entity3 risk was also not associated with current @entity4 RA use (adj. OR 0.78; 95  % CI 0.44-1.39). In our nation-wide case-control study, we identified that the use of @entity4 RA was not associated with @entity1 risk as compared to the use of other anti- @entity2 drugs. Additionally, current @entity4 RA use, stratified by cumulative or average daily dose, is not associated with @entity1 risk. Further research should focus on long-term use of @entity4 RA and @entity1 risk.

title: Use of Glucagon-Like-Peptide 1 Receptor Agonists and Risk of XXXX as Compared to Use of Other Anti- @entity2 Drugs.

answer: @entity1


abstract: BACKGROUND: Recent studies have suggested a strong association between @entity1 ( @entity1 ) and @entity2 ( @entity2 ). However, the impact of continuous positive airway pressure (CPAP) therapy on reverse @entity5 in @entity0 with @entity1 is poorly understood. We aimed to determine the impact of CPAP therapy on total atrial conduction time measured by PA tissue Doppler imaging (TDI) interval in @entity0 without history of @entity2 . METHODS AND RESULTS: Thirty-five @entity0 with first diagnosed @entity1 (group 1) and 20 reference @entity0 without @entity1 (group 2) were prospectively enrolled. Group 1 was divided into 25 @entity0 with starting CPAP therapy (intervention group) and 10 @entity0 without CPAP therapy (control group). PA-TDI interval, measured by tissue Doppler imaging, and @entity4 ( @entity4 ) were determined at baseline and repeated after 30 days in group 1. @entity0 with @entity1 had a significantly longer PA-TDI interval (131.4  16.0ms vs. 120.1  6.4ms, p<0.001) compared to reference @entity0 . PA-TDI interval shortened significantly after 30 days of CPAP therapy (131  17.1ms vs. 124.6  15.7ms, p<0.001), whereas no significant change was found in the control group (132.6  13.6ms vs. 133.2  13.1ms, p=0.31) and @entity4 -levels decreased significantly (39.1  50.7pg/ml vs. 28.2  42.4pg/ml, p<0.01), while @entity4 -levels remained unaffected after 30 days in control group (31.5  20pg/ml vs. 34.4  20.5pg/ml, p=0.41). CONCLUSIONS: Change in PA-TDI interval, as an indirect surrogate marker of @entity5 , suggests reverse @entity5 in @entity0 with @entity1 and treated by CPAP. This effect may ensue from decreased atrial pressure or @entity3 , as indicated by significantly reduced @entity4 levels. These observations suggest that the substrate pre-disposing to @entity2 may be reversible and moreover can be measured by PA-TDI interval and @entity4 .

title: Reverse Remodelling of the Atria After Treatment of XXXX with Continuous Positive Airway Pressure: Evidence from Electro-mechanical and Endocrine Markers.

answer: @entity1


abstract: @entity4 and @entity3 have been thought to represent a single condition. Different clinical presentations for the disorders have been attributed to cultural stereotyping and diagnostic bias. The present study carefully examines detailed @entity1 histories taken from 560 nonpatient university students. Diagnoses of @entity4 and @entity3 are based on the diagnostic criteria for @entity1 research of Feighner et al. Interviewer bias is avoided. Both disorders were present in both sexes. @entity3 was more common for women, whereas @entity4 occurred more frequently in @entity0 . The two disorders presented with nearly equal frequency in @entity0 . @entity3 was more frequent and @entity4 was less frequent in @entity0 than in @entity0 . The two disorders were associated for @entity0 but not for @entity0 . Specific symptoms of @entity4 were associated with @entity3 and were identified. Specific symptoms of @entity3 were associated with @entity4 , differed in some respects between @entity0 and @entity0 , and demonstrated more symptoms of @entity2 for female sociopaths. @entity4 , @entity3 , and their combinations considered together as a possible single entity occurred with equal frequency for both sexes.

title: XXXX and @entity4 . A single disorder?

answer: @entity3


abstract: @entity4 and @entity3 have been thought to represent a single condition. Different clinical presentations for the disorders have been attributed to cultural stereotyping and diagnostic bias. The present study carefully examines detailed @entity1 histories taken from 560 nonpatient university students. Diagnoses of @entity4 and @entity3 are based on the diagnostic criteria for @entity1 research of Feighner et al. Interviewer bias is avoided. Both disorders were present in both sexes. @entity3 was more common for women, whereas @entity4 occurred more frequently in @entity0 . The two disorders presented with nearly equal frequency in @entity0 . @entity3 was more frequent and @entity4 was less frequent in @entity0 than in @entity0 . The two disorders were associated for @entity0 but not for @entity0 . Specific symptoms of @entity4 were associated with @entity3 and were identified. Specific symptoms of @entity3 were associated with @entity4 , differed in some respects between @entity0 and @entity0 , and demonstrated more symptoms of @entity2 for female sociopaths. @entity4 , @entity3 , and their combinations considered together as a possible single entity occurred with equal frequency for both sexes.

title: @entity3 and XXXX . A single disorder?

answer: @entity4


abstract: UNASSIGNED: @entity2 ( @entity2 / @entity4 ) is a @entity0 @entity6 with central roles in mRNA decay and translation repression. To help our understanding of how @entity2 performs these multiple functions, we conducted the first unbiased, large-scale study to map the @entity2 -centric protein-protein interactome using immunoprecipitation and mass spectrometry. Using @entity2 as bait, we identify a high-confidence and high-quality set of protein interaction partners which are enriched for functions in RNA metabolism and ribosomal proteins. The screen is highly specific, maximizing the number of true positives, as demonstrated by the validation of 81% (47/58) of the RNA-independent interactors through known functions and interactions. Importantly, we minimize the number of indirect interaction partners through use of a nuclease-based digestion to eliminate RNA. We describe eleven new interactors, including proteins involved in splicing which is an as-yet unknown role for @entity2 . We validated and characterized in more detail the interaction of @entity2 with Nuclear @entity1 -interacting protein 2 ( @entity5 ) and with two previously uncharacterized proteins, @entity7 and @entity8 (here referred to as granulin-1 and granulin-2, or GRAN1 and GRAN2). We show that @entity5 , GRAN1, and GRAN2 are not P-body components, but re-localize to stress granules upon exposure to stress, suggesting a function in translation repression in the cellular stress response. Using a complementary analysis that resolved @entity2 's multiple complex memberships, we further validated these interaction partners and the presence of splicing factors. As @entity2 also interacts with the E3 SUMO ligase @entity3 , we tested for and observed a significant enrichment of sumoylation amongst @entity2 's interaction partners. Our results represent the most comprehensive screen for direct interaction partners of a key regulator of RNA life cycle and localization, highlighting new stress granule components and possible @entity2 functions-many of which are likely conserved across eukaryotes.

title: Comprehensive Protein Interactome Analysis of a Key XXXX : Detection of Novel Stress Granule Proteins.

answer: @entity6


abstract: BACKGROUND: @entity6 type 1 ( @entity7 ) is a rare disease. Creating registry for such a disease is of outstanding importance since it provides us with a full spectrum of the disorder. AIM: To assess variability of different multisystemic features in a large cohort of @entity0 with @entity7 . @entity0 AND METHOD: Data from the Serbian registry for @entity6 were used in the study. Final number of included @entity7 subjects was 275. RESULTS: Registry included 53.8% of male @entity0 . Age at enrollment was 47.2        9.9years, mean disease duration 20.4        9.9years, and mean CTG repeats number 598.3        269.8.Progression of @entity2 was pretty slow, slower in proximal than distal muscles, and slower in arms than in legs. Severe ECG abnormality was found in 25.0% of @entity0 and pacemaker was implanted in 9.5%. Lens opacities were observed in 83.5% of @entity7 @entity0 and 35.3% had @entity8 . @entity1 were very common, while 19.5% of @entity0 had @entity4 and 37.8% hypochloremia. Sterility was found in 20.5% of males and 4.1% of females. @entity5 was found in 36.4% of @entity0 and @entity3 in 29.9%. CONCLUSIONS: We defined the most common characteristics of our @entity7 @entity0 and observed some treatable symptoms that have been neglected previously. Certain findings deserve further investigations in terms of their causes and consequences. Besides this, presented data analysis directs us to make further improvements of the Registry.

title: Variability of multisystemic features in XXXX type 1 - lessons from Serbian registry.

answer: @entity6


abstract: @entity3 is a highly malignant @entity1 of trophoblastic origin. @entity7 is an extremely rare occurrence, especially in @entity0 over 50 years of age. This article concerns a case of @entity3 developing in a 54-year-old @entity0 , which the authors present together with a brief review of the literature. The @entity0 presented with irregular @entity5 for two months, following three months of @entity4 . @entity2 (CT) scan showed an adnexal cystomic-solid mass. Her serum human chorionic gonadotropin ( @entity6 ) levels were 29,1116 mIU/ml. The @entity0 underwent hysterectomy and bisalpingo-oophorectomy. Histology was suggestive of @entity3 . Immunohistochemistry tests were positive for the @entity6 , Ki 67, CK, @entity9 , and negative for @entity8 , supporting the diagnosis of @entity3 . A combination of 5-Fu and KSM was administrated postoperatively. After four cycles of chemotherapy, her serum @entity6 level fell to the normal range. The @entity0 remains disease-free 14 months after disease diagnosis.

title: Primary XXXX : a case report and literature review.

answer: @entity7


abstract: UNASSIGNED: Two of the most important challenges facing humanity in the 21st century comprise food production and disease control. Eco-friendly control tools against mosquito vectors and agricultural pests are urgently needed. Insecticidal products of marine origin have a huge potential to control these pests. In this research, we reported a single-step method to synthesize @entity1 nanoparticles (AgNP) using the aqueous leaf extract of the seaweed Hypnea musciformis, a cheap, nontoxic and eco-friendly material, that worked as reducing and stabilizing agent during the biosynthesis. The formation of AgNP was confirmed by surface plasmon resonance band illustrated in UV-vis spectrophotometer. AgNP were characterized by FTIR, SEM, EDX and XRD analyses. AgNP were mostly spherical in shape, crystalline in nature, with face-centered cubic geometry, and their mean size was 40-65nm. Low doses of H. musciformis aqueous extract and seaweed-synthesized @entity3 showed larvicidal and @entity0 against the dengue vector @entity2 and the @entity4 . The LC50 value of AgNP ranged from 18.14 to 38.23ppm for 1st instar larvae (L1) and pupae of A. aegypti, and from 24.5 to 38.23ppm for L1 and pupae of P. xylostella. Both H. musciformis extract and AgNP strongly reduced longevity and fecundity of A. aegypti and P. xylostella adults. This study adds knowledge on the @entity0 of seaweed borne insecticides and green-synthesized AgNP against arthropods of medical and agricultural importance, allowing us to propose the tested products as effective candidates to develop newer and cheap pest control tools.

title: Characterization and biotoxicity of Hypnea musciformis-synthesized XXXX nanoparticles as potential eco-friendly control tool against @entity2 and Plutella xylostella.

answer: @entity1


abstract: UNASSIGNED: Two of the most important challenges facing humanity in the 21st century comprise food production and disease control. Eco-friendly control tools against mosquito vectors and agricultural pests are urgently needed. Insecticidal products of marine origin have a huge potential to control these pests. In this research, we reported a single-step method to synthesize @entity1 nanoparticles (AgNP) using the aqueous leaf extract of the seaweed Hypnea musciformis, a cheap, nontoxic and eco-friendly material, that worked as reducing and stabilizing agent during the biosynthesis. The formation of AgNP was confirmed by surface plasmon resonance band illustrated in UV-vis spectrophotometer. AgNP were characterized by FTIR, SEM, EDX and XRD analyses. AgNP were mostly spherical in shape, crystalline in nature, with face-centered cubic geometry, and their mean size was 40-65nm. Low doses of H. musciformis aqueous extract and seaweed-synthesized @entity3 showed larvicidal and @entity0 against the dengue vector @entity2 and the @entity4 . The LC50 value of AgNP ranged from 18.14 to 38.23ppm for 1st instar larvae (L1) and pupae of A. aegypti, and from 24.5 to 38.23ppm for L1 and pupae of P. xylostella. Both H. musciformis extract and AgNP strongly reduced longevity and fecundity of A. aegypti and P. xylostella adults. This study adds knowledge on the @entity0 of seaweed borne insecticides and green-synthesized AgNP against arthropods of medical and agricultural importance, allowing us to propose the tested products as effective candidates to develop newer and cheap pest control tools.

title: Characterization and biotoxicity of Hypnea musciformis-synthesized @entity1 nanoparticles as potential eco-friendly control tool against XXXX and Plutella xylostella.

answer: @entity2


abstract: OBJECTIVE: To explore the relationship between continuous @entity3 and @entity2 in @entity0 with severe burns. METHODS: Clinical data of 148 severely @entity5 @entity0 admitted to our,two burn centers from January 2007 to December 2011 and conforming to the study criteria were retrospectively analyzed. All @entity0 were divided into @entity2 group (n =44) and non- @entity2 group (n = 104) according to the presence or absence of @entity2 within @entity5 ( @entity5 ) 30. The data of age, gender, total burn area, full-thickness burn area, fluid infusion volume within post burn hour (PBH) 24, plasma concentration of calcium ion on @entity5 1, plasma concentration of albumin on @entity5 1, platelet count on @entity5 1, acute physiology and chronic health evaluation (APACHE) II score on admission, the presence or absence of @entity4 or @entity1 on admission, the presence or absence of @entity6 ( @entity6 ) within PBH 48, operation or no operation within @entity5 3, @entity3 duration within @entity5 10, and mortality were statistically compared between two groups to screen the independent risk factors of @entity2 . Data were processed with t test, chi-square test, single factor Logistic regression analysis, and multi-factor Logistic regression analysis. RESULTS: Between two groups, there were statistically significant differences in total burn area, full-thickness burn area, plasma concentration of calcium ion on @entity5 1, plasma concentration of albumin on @entity5 1, APACHE II score on admission, presence or absence of hypovolem- ic shock on admission, presence or absence of @entity1 on admission, presence or absence of @entity6 within PBH 48, and mortality (with t values from 2.433 to 4.082,   2 values from 8. 818 to 31.528, P < 0.05 or P < 0.01). Furthermore, the duration of @entity3 within @entity5 10 in @entity2 group was (5.2    2.4) d, which was significantly longer than that in non- @entity2 group [(2.9    1.9) d, t =6. 189, P <0.01]. There were no statistically significant differences in the other indexes between two groups (with t values from 0.971 to 1. 250,   2 values respectively 0. 054 and 1.529, P values above 0.05). Single factor and multi-factor Logistic regression analysis indicated that APACHE II score on admission and duration of @entity3 within @entity5 10 were closely related to occurrence of @entity2 (with odds ratio respectively 1. 140 and 1.569, P values below 0.01). CONCLUSIONS: Duration of @entity3 within @entity5 10 is one of the risk factors for @entity2 in severely @entity5 @entity0 , which can reflect pathophysiological changes in the body, thus providing predictive value for the occurrence of @entity2 .

title: [Clinical significance of continuous @entity3 in predicting XXXX after severe burn].

answer: @entity2


abstract: OBJECTIVE: To explore the relationship between continuous @entity3 and @entity2 in @entity0 with severe burns. METHODS: Clinical data of 148 severely @entity5 @entity0 admitted to our,two burn centers from January 2007 to December 2011 and conforming to the study criteria were retrospectively analyzed. All @entity0 were divided into @entity2 group (n =44) and non- @entity2 group (n = 104) according to the presence or absence of @entity2 within @entity5 ( @entity5 ) 30. The data of age, gender, total burn area, full-thickness burn area, fluid infusion volume within post burn hour (PBH) 24, plasma concentration of calcium ion on @entity5 1, plasma concentration of albumin on @entity5 1, platelet count on @entity5 1, acute physiology and chronic health evaluation (APACHE) II score on admission, the presence or absence of @entity4 or @entity1 on admission, the presence or absence of @entity6 ( @entity6 ) within PBH 48, operation or no operation within @entity5 3, @entity3 duration within @entity5 10, and mortality were statistically compared between two groups to screen the independent risk factors of @entity2 . Data were processed with t test, chi-square test, single factor Logistic regression analysis, and multi-factor Logistic regression analysis. RESULTS: Between two groups, there were statistically significant differences in total burn area, full-thickness burn area, plasma concentration of calcium ion on @entity5 1, plasma concentration of albumin on @entity5 1, APACHE II score on admission, presence or absence of hypovolem- ic shock on admission, presence or absence of @entity1 on admission, presence or absence of @entity6 within PBH 48, and mortality (with t values from 2.433 to 4.082,   2 values from 8. 818 to 31.528, P < 0.05 or P < 0.01). Furthermore, the duration of @entity3 within @entity5 10 in @entity2 group was (5.2    2.4) d, which was significantly longer than that in non- @entity2 group [(2.9    1.9) d, t =6. 189, P <0.01]. There were no statistically significant differences in the other indexes between two groups (with t values from 0.971 to 1. 250,   2 values respectively 0. 054 and 1.529, P values above 0.05). Single factor and multi-factor Logistic regression analysis indicated that APACHE II score on admission and duration of @entity3 within @entity5 10 were closely related to occurrence of @entity2 (with odds ratio respectively 1. 140 and 1.569, P values below 0.01). CONCLUSIONS: Duration of @entity3 within @entity5 10 is one of the risk factors for @entity2 in severely @entity5 @entity0 , which can reflect pathophysiological changes in the body, thus providing predictive value for the occurrence of @entity2 .

title: [Clinical significance of continuous XXXX in predicting @entity2 after severe burn].

answer: @entity3


abstract: OBJECTIVE: To identify potential neuromuscular factors associated with dynamic balance in individuals with @entity3 ( @entity2 ). DESIGN: Cross-sectional observational study; backward stepwise multiple linear regression was used to identify factors associated with dynamic balance in 2 statistical models. SETTING: University clinical research laboratory. @entity0 : Individuals aged >= 50 years (N=52) with osteoarthritic changes on radiograph participated. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Dynamic balance was assessed using the Community Balance and Mobility Scale (CB_M). Potentially modifiable neuromuscular factors associated with dynamic balance were measured, including the sum of concentric and eccentric lower-extremity muscle strength, 2 quadriceps-hamstrings muscle strength ratios, @entity4 (joint position sense), anticipatory postural control velocity, and knee joint range of motion. RESULTS: The first model for explaining variance in CB_M scores consisted of eccentric lower-extremity muscle strength and knee joint range of motion as factors. The model containing these 2 variables explained 50% of the variance in CB_M scores. The second model adjusted for descriptive variables, including age, body mass index, and knee @entity1 , contained only the neuromuscular variables eccentric lower-extremity muscle strength, and explained 68% of the variance in CB_M scores. CONCLUSIONS: These results suggest that muscle strength and, to a lesser extent, knee joint range of motion are important factors associated with dynamic balance as measured by the CB_M and should be considered in dynamic balance interventions.

title: Factors Associated With Dynamic Balance in @entity0 With XXXX .

answer: @entity3


abstract: OBJECTIVE: To identify potential neuromuscular factors associated with dynamic balance in individuals with @entity3 ( @entity2 ). DESIGN: Cross-sectional observational study; backward stepwise multiple linear regression was used to identify factors associated with dynamic balance in 2 statistical models. SETTING: University clinical research laboratory. @entity0 : Individuals aged >= 50 years (N=52) with osteoarthritic changes on radiograph participated. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Dynamic balance was assessed using the Community Balance and Mobility Scale (CB_M). Potentially modifiable neuromuscular factors associated with dynamic balance were measured, including the sum of concentric and eccentric lower-extremity muscle strength, 2 quadriceps-hamstrings muscle strength ratios, @entity4 (joint position sense), anticipatory postural control velocity, and knee joint range of motion. RESULTS: The first model for explaining variance in CB_M scores consisted of eccentric lower-extremity muscle strength and knee joint range of motion as factors. The model containing these 2 variables explained 50% of the variance in CB_M scores. The second model adjusted for descriptive variables, including age, body mass index, and knee @entity1 , contained only the neuromuscular variables eccentric lower-extremity muscle strength, and explained 68% of the variance in CB_M scores. CONCLUSIONS: These results suggest that muscle strength and, to a lesser extent, knee joint range of motion are important factors associated with dynamic balance as measured by the CB_M and should be considered in dynamic balance interventions.

title: Factors Associated With Dynamic Balance in XXXX With @entity3 .

answer: @entity0


abstract: PURPOSE: A pneumatic tourniquet is commonly used in total knee arthroplasty (TKA) to improve surgical field visualisation but may result in @entity2 muscle ischaemia. We performed this study to analyse the effect of the tourniquet on recovery following TKA. MATERIALS AND METHODS: A prospective randomised single-blinded trial was undertaken to examine the effect of the tourniquet on post-operative @entity3 , @entity1 , @entity4 , @entity2 function and outcome following TKA. Twenty @entity0 with @entity5 of the knee were randomised to tourniquet or no tourniquet groups. Quadriceps function was assessed using surface electromyography (EMG) during active knee extension. RESULTS: The no tourniquet group had significantly less @entity3 in the early post-operative period compared to the tourniquet group. There was no difference in Oxford knee score, range of motion, or thigh and knee @entity1 up to 12 months post-operatively. Quadriceps function, measured by surface EMG, was compromised for the first six months post-surgery by tourniquet use. The radiological cement mantle at the bone prosthesis interface at 12-month follow-up was not affected by the absence of a tourniquet. CONCLUSIONS: We believe that it is safe and beneficial for our @entity0 to routinely perform TKA without a tourniquet.

title: Effects of tourniquet use on XXXX function and @entity3 in total knee arthroplasty.

answer: @entity2


abstract: PURPOSE: A pneumatic tourniquet is commonly used in total knee arthroplasty (TKA) to improve surgical field visualisation but may result in @entity2 muscle ischaemia. We performed this study to analyse the effect of the tourniquet on recovery following TKA. MATERIALS AND METHODS: A prospective randomised single-blinded trial was undertaken to examine the effect of the tourniquet on post-operative @entity3 , @entity1 , @entity4 , @entity2 function and outcome following TKA. Twenty @entity0 with @entity5 of the knee were randomised to tourniquet or no tourniquet groups. Quadriceps function was assessed using surface electromyography (EMG) during active knee extension. RESULTS: The no tourniquet group had significantly less @entity3 in the early post-operative period compared to the tourniquet group. There was no difference in Oxford knee score, range of motion, or thigh and knee @entity1 up to 12 months post-operatively. Quadriceps function, measured by surface EMG, was compromised for the first six months post-surgery by tourniquet use. The radiological cement mantle at the bone prosthesis interface at 12-month follow-up was not affected by the absence of a tourniquet. CONCLUSIONS: We believe that it is safe and beneficial for our @entity0 to routinely perform TKA without a tourniquet.

title: Effects of tourniquet use on @entity2 function and XXXX in total knee arthroplasty.

answer: @entity3


abstract: We report a rare case of a @entity1 treated with endoscopic resection and oral @entity2 therapy. A 70-year-old @entity0 was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The @entity0 was diagnosed with extramedullary @entity1 . Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The @entity0 's condition was found to be stable.

title: Successful treatment of a @entity1 using a combination of endoscopic submucosal dissection and oral XXXX .

answer: @entity2


abstract: We report a rare case of a @entity1 treated with endoscopic resection and oral @entity2 therapy. A 70-year-old @entity0 was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The @entity0 was diagnosed with extramedullary @entity1 . Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The @entity0 's condition was found to be stable.

title: Successful treatment of a XXXX using a combination of endoscopic submucosal dissection and oral @entity2 .

answer: @entity1


abstract: PURPOSE: To compare the clinical usefulness of reduced field-of-view diffusion-weighted imaging (rFOV) with other imaging techniques in determining the depth of @entity1 (DMI) in @entity2 . MATERIALS AND METHODS: In this prospective study we reviewed 3T magnetic resonance images of 51 @entity0 with clinical Stage I @entity2 who underwent total abdominal hysterectomy with bilateral salphingoopherectomy within 3 days after imaging. rFOV with apparent diffusion coefficient reconstruction was obtained in three standard planes followed by sagittal T2 -weighted (T2 WI) images and 3D dynamic T1 -weighted and contrast-enhanced imaging ( @entity3 MRI). Two radiologists with expertise in imaging gynecologic cancers evaluated images independently. The DMI was recorded on imaging and correlated with surgical pathology results. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DMI were calculated (<50% vs. >50%). RESULTS: Compared with sagittal T2 WI   +   @entity3 MRI, rFOV imaging yielded greater specificity (82.2% vs. 90.0%, positive predictive value (42.8% vs. 60.0%), and accuracy (84.0% vs. 92%) for DMI determined by reader 1 and greater the sensitivity (83.3% vs. 100%) for DMI determined by reader 2. The error of measurement of DMI as a continuous variable in millimeters did not differ significantly between the rFOV and pathology results (P < 0.21). However, there was a statistically significant difference for the DMI measured on the dynamic sequence. The DMI on @entity3 was greater than that seen on pathology at P   =   0.02. CONCLUSION: rFOV can be used to assess DMI in clinical Stage I @entity2 . J. Magn. Reson. Imaging 2015.

title: Feasibility of a reduced field-of-view diffusion-weighted (rFOV) sequence in assessment of XXXX in @entity0 with clinical FIGO stage I @entity2 .

answer: @entity1


abstract: PURPOSE: To compare the clinical usefulness of reduced field-of-view diffusion-weighted imaging (rFOV) with other imaging techniques in determining the depth of @entity1 (DMI) in @entity2 . MATERIALS AND METHODS: In this prospective study we reviewed 3T magnetic resonance images of 51 @entity0 with clinical Stage I @entity2 who underwent total abdominal hysterectomy with bilateral salphingoopherectomy within 3 days after imaging. rFOV with apparent diffusion coefficient reconstruction was obtained in three standard planes followed by sagittal T2 -weighted (T2 WI) images and 3D dynamic T1 -weighted and contrast-enhanced imaging ( @entity3 MRI). Two radiologists with expertise in imaging gynecologic cancers evaluated images independently. The DMI was recorded on imaging and correlated with surgical pathology results. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DMI were calculated (<50% vs. >50%). RESULTS: Compared with sagittal T2 WI   +   @entity3 MRI, rFOV imaging yielded greater specificity (82.2% vs. 90.0%, positive predictive value (42.8% vs. 60.0%), and accuracy (84.0% vs. 92%) for DMI determined by reader 1 and greater the sensitivity (83.3% vs. 100%) for DMI determined by reader 2. The error of measurement of DMI as a continuous variable in millimeters did not differ significantly between the rFOV and pathology results (P < 0.21). However, there was a statistically significant difference for the DMI measured on the dynamic sequence. The DMI on @entity3 was greater than that seen on pathology at P   =   0.02. CONCLUSION: rFOV can be used to assess DMI in clinical Stage I @entity2 . J. Magn. Reson. Imaging 2015.

title: Feasibility of a reduced field-of-view diffusion-weighted (rFOV) sequence in assessment of @entity1 in @entity0 with clinical FIGO stage I XXXX .

answer: @entity2


abstract: PURPOSE: To compare the clinical usefulness of reduced field-of-view diffusion-weighted imaging (rFOV) with other imaging techniques in determining the depth of @entity1 (DMI) in @entity2 . MATERIALS AND METHODS: In this prospective study we reviewed 3T magnetic resonance images of 51 @entity0 with clinical Stage I @entity2 who underwent total abdominal hysterectomy with bilateral salphingoopherectomy within 3 days after imaging. rFOV with apparent diffusion coefficient reconstruction was obtained in three standard planes followed by sagittal T2 -weighted (T2 WI) images and 3D dynamic T1 -weighted and contrast-enhanced imaging ( @entity3 MRI). Two radiologists with expertise in imaging gynecologic cancers evaluated images independently. The DMI was recorded on imaging and correlated with surgical pathology results. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DMI were calculated (<50% vs. >50%). RESULTS: Compared with sagittal T2 WI   +   @entity3 MRI, rFOV imaging yielded greater specificity (82.2% vs. 90.0%, positive predictive value (42.8% vs. 60.0%), and accuracy (84.0% vs. 92%) for DMI determined by reader 1 and greater the sensitivity (83.3% vs. 100%) for DMI determined by reader 2. The error of measurement of DMI as a continuous variable in millimeters did not differ significantly between the rFOV and pathology results (P < 0.21). However, there was a statistically significant difference for the DMI measured on the dynamic sequence. The DMI on @entity3 was greater than that seen on pathology at P   =   0.02. CONCLUSION: rFOV can be used to assess DMI in clinical Stage I @entity2 . J. Magn. Reson. Imaging 2015.

title: Feasibility of a reduced field-of-view diffusion-weighted (rFOV) sequence in assessment of @entity1 in XXXX with clinical FIGO stage I @entity2 .

answer: @entity0


abstract: PURPOSE OF THE STUDY: Nonpharmacological, psychosocial approaches are first-line treatments for managing behavioral symptoms in @entity2 , but they can be challenging to implement in long-term care settings. The Veterans Health Administration implemented STAR-VA, an interdisciplinary behavioral approach for managing challenging @entity2 -related behaviors in its Community Living Center (CLCs, nursing home care) settings. This study describes how the program was implemented and provides an evaluation of Veteran clinical outcomes and staff feedback on the intervention. DESIGN AND METHODS: One mental health professional and registered nurse team from 17 CLCs completed STAR-VA training, which entailed an experiential workshop followed by 6 months of expert consultation as they worked with their teams to implement STAR-VA with Veterans identified to have challenging @entity2 -related behaviors. The frequency and severity of @entity0 and symptoms of @entity3 , @entity1 , and @entity4 were evaluated at baseline and at intervention completion. Staff provided feedback regarding STAR-VA feasibility and impact. RESULTS: Seventy-one Veterans completed the intervention. Behaviors clustered into 6 types: care refusal or resistance, @entity4 , @entity0 , vocalization, wandering, and other. Frequency and severity of @entity0 and symptoms of @entity3 , @entity1 , and @entity4 all significantly decreased, with overall effect sizes of 1 or greater. Staff rated both benefits for Veterans and program feasibility favorably. IMPLICATIONS: This evaluation supports the feasibility and effectiveness of STAR-VA, an interdisciplinary, behavioral intervention for managing @entity0 among residents with @entity2 in CLCs.

title: Effectiveness of Expanded Implementation of STAR-VA for Managing XXXX -Related Behaviors Among Veterans.

answer: @entity2


abstract: AIM: The aim of this study was to analyse the influence of birthweight on motor performance and body composition in @entity0 . Further, we investigated whether associations between birthweight and motor performance changed after adjustment for current height, body mass index (BMI), @entity2 ( @entity2 ), and % body fat. METHOD: A total of 483 @entity0 (251 males and 232 females) aged 7 to 10  years (mean 8.78, SD 1.0y) born in Vit  ria Santo Ant  o (northeast Brazil) were sampled. Motor performance was operationalized using different physical fitness components and gross motor coordination. Physical fitness was measured by handgrip strength, muscle endurance, explosive power, flexibility, agility, running speed, and maximal @entity1 consumption (VO2max ). Gross motor coordination was evaluated by means of the K  rper Koordination Test f  r Kinder (KTK). RESULTS: Positive correlations between birthweight and height, BMI, and @entity2 were found. Birthweight was positively correlated with handgrip strength and negatively correlated with 20-meter sprint time, even after controlling for age, height, BMI, @entity2 , and % body fat. Birthweight was negatively associated with relative VO2max (mL/kg/min); however, the association was no longer significant after inclusion of BMI or @entity2 in the model. INTERPRETATION: Birthweight significantly predicted height, BMI, @entity2 , and performance in strength and velocity tests, but did not influence gross motor coordination.

title: Birthweight, body composition, and motor performance in 7- to 10-year-old XXXX .

answer: @entity0


abstract: BACKGROUND: -Exercise training has been shown to improve @entity3 , physical capacity and quality of life in @entity0 with cardiopulmonary conditions such as @entity4 and @entity5 . However, its role in management of @entity2 is not well defined. In this study, we aim to evaluate the efficacy and safety of exercise training in @entity0 with @entity2 . METHODS AND RESULTS: -We included all prospective intervention studies that evaluated the efficacy and safety of exercise training in @entity0 with @entity2 . Primary outcome of this meta-analysis was a change in six-minute walk distance (6MWD). We also assessed the effect of exercise on peak @entity1 uptake (VO2peak), resting pulmonary arterial systolic pressure (PASP), peak exercise heart rate (HRpeak), and quality of life. A total of 16 studies with 434 exercise-training @entity0 were included. In the pooled analysis, exercise training was associated with significant improvement in 6MWD [Weighted mean difference (WMD): 57.7 meters (95% CI: 42.5 to 72.8)], VO2peak [WMD = 1.7 ml/kg/min (95% CI: 1.3 to 2.0)], PASP [WMD = -3.6 mmHg (95% CI = -5.8 to -1.4)], HRpeak [WMD = 10.4 beats per min (95% CI: 5.5 to 15.3)], and quality of life as measured on SF-36 questionnaire subscale scores. Furthermore, exercise training was well tolerated with a low dropout rate and no major adverse events related to exercise training. CONCLUSIONS: -Exercise training in @entity0 with @entity2 appears safe and is associated with a significant improvement in exercise capacity, pulmonary arterial pressure and quality of life.

title: Efficacy and Safety of Exercise Training in XXXX : A Systematic Review and Meta-Analysis.

answer: @entity2


abstract: BACKGROUND: We sought to evaluate the impact of the evolution of a pediatric @entity1 ( @entity1 ) program on outcomes of @entity0 listed for heart transplantation at our institution. METHODS: All @entity0 listed for isolated heart transplantation from 1995 to 2013 were included. The use of @entity1 while on the wait-list was recorded. Wait-list and posttransplant outcomes were compared before and after 2005, which was when we became capable of providing long-term @entity1 without size limitation. RESULTS: In total, 259 @entity0 were listed for transplant and 201 (78%) reached transplant. The use of @entity1 was significantly increased between the eras (13% and 37%, p  = 0.0001). Wait-list mortality was significantly decreased (25% and 11%, p  = 0.0006). Among transplant recipients, the proportion of @entity0 who underwent @entity1 was significantly increased (13% and 37%, p  = 0.0002). Of these @entity1 @entity0 , the use of long-term devices was significantly increased (50% and 98%, p  = 0.0004). Median duration of @entity1 was significantly increased (12 and 78 days, p  = 0.004). Kaplan-Meier estimates showed a trend (p  = 0.08) toward improved survival after bridge-to-transplant both at 1 year (70% in the early @entity2 and 88% in the late @entity2 ) and at 5 years (60% and 78%, respectively). CONCLUSIONS: Outcomes of pediatric heart transplantation have significantly improved over the last 2 decades. We believe such improvement is, at least in part, attributable to maturation of @entity1 strategy, characterized by avoiding the use of temporary devices such as extracorporeal membrane oxygenation as a bridge-to-transplant and a more aggressive use of long-term devices.

title: Evolution and Impact of Ventricular Assist Device Program on XXXX Awaiting Heart Transplantation.

answer: @entity0