abstract: OBJECTIVE: Obesity is a major public health problem. Regulating food intake and promoting metabolism of fat are two important options for treating @entity0 . Auricular vagus nerve stimulation (AVNS) is considered as an alternative approach to vagal nerve stimulation. The aim of this study was to investigate the effects of AVNS and its mechanisms on @entity0 in @entity0 @entity1 . METHODS: Male @entity1 were fed either a high-fat diet (HFD) or a normal diet for 8  wk. Qualified HFD @entity1 were randomly divided into three groups: the HFD group, the AVNS group, and the sham group for 6  wk treatment. Body weight and daily energy intake were recorded weekly. The @entity1 were sacrificed for measurement of weight of bilateral perirenal, epididymal @entity3 ( @entity3 ), dorsal brown adipose tissue (BAT), and gastric emptying. Serum cholecystokinin ( @entity5 ), peptide YY3 to 36 (PYY3-36) and @entity2 (NE) were assayed by enzyme-linked immunosorbent assay. Real-time quantitative polymerase chain reaction was used to assess the mRNA expressions of @entity5 subtype receptor a (CCKa) in the antrum, PYY3-36 receptor in the distal ileum, b3-adrenoceptor, and uncoupling protein gene 1 ( @entity4 ) in the BAT. RESULTS: Compared with HFD group, AVNS significantly reduced body @entity3 and increased BAT weight, serum NE, mRNA expressions of b3-adrenoceptors, and @entity4 of the BAT, but had no effect on daily energy intake, perirenal @entity3 weight, gastric emptying, serum levels of @entity5 and @entity6 , or mRNA expressions of CCKa receptor and PYY3-36 receptor in the relevant tissues. The sham group, as a comparison group for AVNS, saw less effect in any of the indexes compared with the HFD group. AVNS had more effect on weight loss, @entity3 , and increase of NE, b3-adrenoceptor, and @entity4 than sham. CONCLUSIONS: AVNS was more effective in reducing body weight and causing visceral fat loss. Biochemical tests found more NE released in the serum and more b3-adrenoceptor and @entity4 expression in the BAT. All of these features suggested that energy expenditure might play an important role in @entity0 management by AVNS.

title: Effects and mechanisms of auricular vagus nerve stimulation on high-fat-diet-induced XXXX @entity1 .

answer: @entity0


abstract: OBJECTIVE: Obesity is a major public health problem. Regulating food intake and promoting metabolism of fat are two important options for treating @entity0 . Auricular vagus nerve stimulation (AVNS) is considered as an alternative approach to vagal nerve stimulation. The aim of this study was to investigate the effects of AVNS and its mechanisms on @entity0 in @entity0 @entity1 . METHODS: Male @entity1 were fed either a high-fat diet (HFD) or a normal diet for 8  wk. Qualified HFD @entity1 were randomly divided into three groups: the HFD group, the AVNS group, and the sham group for 6  wk treatment. Body weight and daily energy intake were recorded weekly. The @entity1 were sacrificed for measurement of weight of bilateral perirenal, epididymal @entity3 ( @entity3 ), dorsal brown adipose tissue (BAT), and gastric emptying. Serum cholecystokinin ( @entity5 ), peptide YY3 to 36 (PYY3-36) and @entity2 (NE) were assayed by enzyme-linked immunosorbent assay. Real-time quantitative polymerase chain reaction was used to assess the mRNA expressions of @entity5 subtype receptor a (CCKa) in the antrum, PYY3-36 receptor in the distal ileum, b3-adrenoceptor, and uncoupling protein gene 1 ( @entity4 ) in the BAT. RESULTS: Compared with HFD group, AVNS significantly reduced body @entity3 and increased BAT weight, serum NE, mRNA expressions of b3-adrenoceptors, and @entity4 of the BAT, but had no effect on daily energy intake, perirenal @entity3 weight, gastric emptying, serum levels of @entity5 and @entity6 , or mRNA expressions of CCKa receptor and PYY3-36 receptor in the relevant tissues. The sham group, as a comparison group for AVNS, saw less effect in any of the indexes compared with the HFD group. AVNS had more effect on weight loss, @entity3 , and increase of NE, b3-adrenoceptor, and @entity4 than sham. CONCLUSIONS: AVNS was more effective in reducing body weight and causing visceral fat loss. Biochemical tests found more NE released in the serum and more b3-adrenoceptor and @entity4 expression in the BAT. All of these features suggested that energy expenditure might play an important role in @entity0 management by AVNS.

title: Effects and mechanisms of auricular vagus nerve stimulation on high-fat-diet-induced @entity0 XXXX .

answer: @entity1


abstract: BACKGROUND: The literature about the relationship between @entity1 ( @entity1 ) and @entity3 location is conflicting with some studies finding an association and others demonstrating no relationship. Among acute @entity4 @entity0 , we sought to examine the relationship between @entity3 location and the prevalence of @entity1 ; @entity1 severity based on @entity1 index (AHI), arousal frequency, and measure of @entity5 ; and number of central and obstructive respiratory events. METHODS: Data were obtained from @entity0 who participated in a randomized controlled trial (NCT01446913) that evaluated the effectiveness of a strategy of diagnosing and treating @entity1 among @entity0 with acute @entity4 and transient @entity2 attack. @entity3 location was classified by brain imaging reports into subdivisions of lobes, subcortical areas, brainstem, cerebellum, and vascular territory. The association between @entity3 and polysomnographic findings was evaluated using logistic regression for @entity1 presence and negative binomial regression for AHI. RESULTS: Among 73 @entity0 with complete polysomnography and @entity3 location data, 58 (79%) had @entity1 . In unadjusted models, no @entity3 location variable was associated with the prevalence or severity of @entity1 . Similarly, in multivariable modeling, groupings of @entity3 location were also not associated with @entity1 presence. CONCLUSIONS: These results indicate that @entity1 is present in the majority of @entity3 @entity0 and imply that @entity3 location cannot be used to identify a group with higher risk of @entity1 . The results also suggest that @entity1 likely predated the @entity3 . Given this high overall prevalence, strong consideration should be given to obtaining polysomnography for all @entity4 @entity0 .

title: Infarct location and sleep apnea: evaluating the potential association in acute XXXX .

answer: @entity4


abstract: OBJECTIVES: Obstructive respiratory events often terminate with an associated respiratory-related leg movement (RRLM). Such leg movements are not scored as periodic leg movements (periodic limb movements during sleep, PLMS), although the criteria for distinguishing RRLM from PLMS differ between the American Academy of Sleep Medicine (AASM) and the World Association of Sleep Medicine (WASM)/ International @entity5 Study Group (IRLSSG) scoring manuals. Such LMs may be clinically significant in @entity0 with @entity1 ( @entity1 ). The prevalence and correlation of RRLM in @entity0 with @entity1 were examined. METHODS: A case-control sample of 575 @entity0 was selected from all @entity0 with an @entity1 index (AHI, >= 3% desaturation criteria)   >=    10 and good data from piezoelectric leg movement sensors at the first in-home sleep study in the @entity6 cohort (mean age   =   76.8 years). Sleep studies were rescored for RRLMs using five different RRLM definitions varying in both latency of leg movement onset from respiratory event termination and duration of the leg movement. The quartile of RRLM% (the number of RRLM/the number of hypopneas   +   @entity3 ) was derived. RESULTS: The nonparametric densities of RRLM% were most influenced by alterations in the latency rather than the duration of the LM. The most liberal RRLM definition (latency 0-5   s, duration 0.5-10   s) led to a median RRLM% of 23.4 (interquartile range 12.41, 37.12) in this sample. The average AHI and arousal index increased as the quartile of RRLM% increased, as well as the prevalence of @entity4 ( @entity4 ). The prevalence of those with a history of @entity2 decreased as RRLM% increased. The non-Caucasian race was associated with lower RRLM%. CONCLUSION: Within an elderly sample with moderate to severe @entity1 , piezoelectric-defined RRLM% is associated with a number of sleep-related and demographic factors. Further study of the optimal definition, predictors, and consequences of RRLM is warranted.

title: Prevalence and associations of respiratory-related leg movements: the XXXX sleep study.

answer: @entity6


abstract: PURPOSE: Knowledge of the specific anatomical information of a @entity0 is important when planning and undertaking laparoscopic surgery due to the restricted field of view and lack of tactile feedback compared to open surgery. To assist this type of surgery, we have developed a surgical navigation system that presents the @entity0 's anatomical information synchronized with the laparoscope position. This paper presents the surgical navigation system and its clinical application to laparoscopic gastrectomy for @entity1 . METHODS: The proposed surgical navigation system generates virtual laparoscopic views corresponding to the laparoscope position recorded with a three-dimensional (3D) positional tracker. The virtual laparoscopic views are generated from preoperative CT images. A point-based registration aligns coordinate systems between the @entity0 's anatomy and image coordinates. The proposed navigation system is able to display the virtual laparoscopic views using the registration result during surgery. RESULTS: We performed surgical navigation during laparoscopic gastrectomy in 23 cases. The navigation system was able to present the virtual laparoscopic views in synchronization with the laparoscopic position. The fiducial registration error was calculated in all 23 cases, and the average was 14.0  mm (range 6.1-29.8). CONCLUSION: The proposed surgical navigation system can provide CT-derived @entity0 anatomy aligned to the laparoscopic view in real time during surgery. This system enables accurate identification of vascular anatomy as a guide to vessel clamping prior to total or partial gastrectomy.

title: Clinical application of a surgical navigation system based on virtual laparoscopy in laparoscopic gastrectomy for XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the effect of the serotonin-norepinephrine re-uptake inhibitor desvenlafaxine on blood pressure and incidence of new onset @entity1 in pooled short-term studies and in two longer-term, randomized withdrawal studies. RESEARCH DESIGN AND METHODS: Data from @entity0 randomly assigned to desvenlafaxine 10   mg to 400   mg/day or placebo in 11 short-term (8-12 weeks), fixed-dose, double-blind, placebo-controlled studies of @entity2 ( @entity2 ) were pooled for analysis; two desvenlafaxine randomized withdrawal studies (36 and 46 weeks) were analyzed separately. CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov , NCT00072774, NCT00073762, NCT00277823, NCT00300378, NCT00384033, NCT00798707, NCT00863798, NCT01121484, NCT00824291, NCT01432457, NCT00075257, NCT00887224. MAIN OUTCOME MEASURES: Outcomes included change from baseline in supine systolic blood pressure (SSBP) and supine diastolic blood pressure (SDBP), assessed using a mixed model repeated measures (MMRM) analysis, and incidence of @entity1 (defined as three consecutive second SDBP measures >= 90   mm Hg AND increase of >= 10   mm Hg from baseline and/or SSBP >= 140   mm Hg AND increase of >= 10   mm Hg), analyzed using Cochran Mantel Hanzael tests. Potential predictors of change in SSBP and SDBP at LOCF were examined by including predictor variables in a regression model. RESULTS: In the pooled, short-term studies, mean changes from baseline over time in SSBP and SDBP were statistically significant compared with placebo for the desvenlafaxine doses of 10   mg/day or greater for SSBP (p    <=   0.0004; MMRM) and 25   mg/day or greater for SDBP (p    <=   0.0449; MMRM). The proportion of @entity0 with new onset @entity1 differed significantly from placebo for the 50, 200, and 400   mg/day doses (1.9%, 2.4%, 4.8%, respectively, vs 0.8%; all p    <=   0.0244). Predictors of change in BP included baseline SDBP, baseline SSBP, dose, body mass index, gender, age, race, and history of @entity1 . LIMITATIONS: Data were pooled from studies which differed somewhat in study design and @entity0 demographics. None of the studies were originally designed to examine treatment effects on BP. Study entry criteria limit generalization of these results to medically stable @entity0 with a primary diagnosis of @entity2 . CONCLUSIONS: Short-term desvenlafaxine treatment was associated with small but statistically significant increases in SSBP and SDBP.

title: Effects of desvenlafaxine on blood pressure in @entity0 treated for XXXX : a pooled analysis.

answer: @entity2


abstract: OBJECTIVE: To evaluate the effect of the serotonin-norepinephrine re-uptake inhibitor desvenlafaxine on blood pressure and incidence of new onset @entity1 in pooled short-term studies and in two longer-term, randomized withdrawal studies. RESEARCH DESIGN AND METHODS: Data from @entity0 randomly assigned to desvenlafaxine 10   mg to 400   mg/day or placebo in 11 short-term (8-12 weeks), fixed-dose, double-blind, placebo-controlled studies of @entity2 ( @entity2 ) were pooled for analysis; two desvenlafaxine randomized withdrawal studies (36 and 46 weeks) were analyzed separately. CLINICAL TRIAL REGISTRATION: www.clinicaltrials.gov , NCT00072774, NCT00073762, NCT00277823, NCT00300378, NCT00384033, NCT00798707, NCT00863798, NCT01121484, NCT00824291, NCT01432457, NCT00075257, NCT00887224. MAIN OUTCOME MEASURES: Outcomes included change from baseline in supine systolic blood pressure (SSBP) and supine diastolic blood pressure (SDBP), assessed using a mixed model repeated measures (MMRM) analysis, and incidence of @entity1 (defined as three consecutive second SDBP measures >= 90   mm Hg AND increase of >= 10   mm Hg from baseline and/or SSBP >= 140   mm Hg AND increase of >= 10   mm Hg), analyzed using Cochran Mantel Hanzael tests. Potential predictors of change in SSBP and SDBP at LOCF were examined by including predictor variables in a regression model. RESULTS: In the pooled, short-term studies, mean changes from baseline over time in SSBP and SDBP were statistically significant compared with placebo for the desvenlafaxine doses of 10   mg/day or greater for SSBP (p    <=   0.0004; MMRM) and 25   mg/day or greater for SDBP (p    <=   0.0449; MMRM). The proportion of @entity0 with new onset @entity1 differed significantly from placebo for the 50, 200, and 400   mg/day doses (1.9%, 2.4%, 4.8%, respectively, vs 0.8%; all p    <=   0.0244). Predictors of change in BP included baseline SDBP, baseline SSBP, dose, body mass index, gender, age, race, and history of @entity1 . LIMITATIONS: Data were pooled from studies which differed somewhat in study design and @entity0 demographics. None of the studies were originally designed to examine treatment effects on BP. Study entry criteria limit generalization of these results to medically stable @entity0 with a primary diagnosis of @entity2 . CONCLUSIONS: Short-term desvenlafaxine treatment was associated with small but statistically significant increases in SSBP and SDBP.

title: Effects of desvenlafaxine on blood pressure in XXXX treated for @entity2 : a pooled analysis.

answer: @entity0


abstract: UNASSIGNED: Soft tissue @entity1 arising in association with genetic or @entity2 have been increasingly reported. @entity4 ( @entity4 ) is a highly aggressive @entity1 of infancy and young childhood, characterized by typical morphology and biallelic inactivation of the @entity5 ( @entity5 /SMARCB5/ @entity5 ) gene on chromosome 22q.2. @entity4 represents a unique clinicopathologic presentation of this @entity1 . We report a case occurring in a female neonate which presented at birth a voluminous left thigh mass. Surgical biopsy performed at day 9 showed morphology and immunoprofile of @entity4 . Staging evaluation identified @entity3 and distant nodules. The mass showed rapid growth. Despite chemotherapy, the @entity1 progressed with exteriorization through the biopsy scar. Chemotherapy was discontinued and treatment limited to palliative care and the @entity0 died on day 51. The @entity1 was homozygous for the @entity5 deletion with apparent de novo heterozygous germ line deletion in the @entity0 , not identified in the parents.

title: Congenital disseminated extrarenal XXXX and @entity4 .

answer: @entity4


abstract: UNASSIGNED: Soft tissue @entity1 arising in association with genetic or @entity2 have been increasingly reported. @entity4 ( @entity4 ) is a highly aggressive @entity1 of infancy and young childhood, characterized by typical morphology and biallelic inactivation of the @entity5 ( @entity5 /SMARCB5/ @entity5 ) gene on chromosome 22q.2. @entity4 represents a unique clinicopathologic presentation of this @entity1 . We report a case occurring in a female neonate which presented at birth a voluminous left thigh mass. Surgical biopsy performed at day 9 showed morphology and immunoprofile of @entity4 . Staging evaluation identified @entity3 and distant nodules. The mass showed rapid growth. Despite chemotherapy, the @entity1 progressed with exteriorization through the biopsy scar. Chemotherapy was discontinued and treatment limited to palliative care and the @entity0 died on day 51. The @entity1 was homozygous for the @entity5 deletion with apparent de novo heterozygous germ line deletion in the @entity0 , not identified in the parents.

title: Congenital disseminated extrarenal @entity4 and XXXX .

answer: @entity4


abstract: BACKGROUND AND PURPOSE: There is a paucity of literature that supports the Consortium of @entity1 Centers guideline that proton density MR imaging is a core spinal cord sequence. We hypothesized that proton density fast spin-echo imaging is superior to T2 fast spin-echo MR imaging for the detection of cervical @entity3 . This study compared the detection rate and conspicuity of cervical @entity3 on sagittal 1.5T proton density fast spin-echo and T2 fast spin-echo MR imaging. MATERIALS AND METHODS: One hundred consecutive @entity0 with @entity1 imaged with 1.5T sagittal proton density fast spin-echo and T2 fast spin-echo cervical cord MR imaging between September 2012 and October 2013 were retrospectively included. The number of @entity2 detected on each sequence was recorded; conspicuity was assessed quantitatively with the lesion-to-cord contrast ratio and lesion-contrast-to-noise ratio. Statistical analysis was performed by using the Wilcoxon signed rank test. RESULTS: Seventy-eight @entity0 had @entity3 detected. Proton density fast spin-echo imaging detected a greater number of lesions (n = 181) compared with T2 fast spin-echo imaging (n = 137, P < .001). Fifteen @entity0 (19%) with abnormal findings on proton density fast spin-echo imaging had normal findings on T2 fast spin-echo imaging; no @entity0 with abnormal T2 fast spin-echo imaging findings had normal proton density fast spin-echo imaging findings. Although proton density fast spin-echo and T2 fast spin-echo imaging had similar lesion-to-cord contrast ratios (proton density fast spin-echo, 0.32    0.01, versus T2 fast spin-echo, 0.33    0.01; P = .43), proton density fast spin-echo had greater lesion-contrast-to-noise ratio (proton density fast spin-echo, 82    3.0, versus T2 fast spin-echo, 64    2.6; P < .001). CONCLUSIONS: Proton density fast spin-echo imaging is superior to T2 fast spin-echo MR imaging for the detection of cervical @entity3 . Proton density fast spin-echo detects @entity3 in @entity0 in whom T2 fast spin-echo findings appear normal. This study forms the evidentiary base for the current Consortium of @entity1 Centers guideline that proton density imaging is a core spinal cord sequence.

title: Proton Density MRI Increases Detection of Cervical Spinal Cord XXXX Lesions Compared with T2-Weighted Fast Spin-Echo.

answer: @entity1


abstract: OBJECTIVE: To evaluate the @entity7 , malocclusions, @entity1 and salivary levels of @entity3 and alpha-amylase in @entity4 @entity0 . DESIGN: 108 7-9-yr-old @entity0 were selected from Policlinic Santa Teresinha Doutor Antonio Haddad Dib (asthmatics, n=53) and from public schools (controls, n=55), Piracicaba, SP, Brazil. Sleep @entity6 diagnosis was confirmed by parental report of grinding sounds and the presence of shiny and polish facets on incisors and/or first permanent molars. The index of orthodontic treatment need was used for occlusion evaluation. @entity1 were evaluated using the nordic orofacial test-screening (NOT-S). Salivary @entity3 and alpha-amylase were expressed as "awakening response" (AR), calculated as the difference between levels immediately after awakening and 30min after waking, and "diurnal decline" ( @entity5 ), calculated as the difference between levels at 30min after waking and at bedtime. Data were analyzed using Shapiro-Wilk/Kolmogorov-Smirnov, Chi-square, unpaired t test/Mann-Whitney and paired t/Wilcoxon tests. RESULTS: Sleep @entity6 was more prevalent in @entity0 with @entity2 than controls (47.2% vs. 27.3%, p<0.05). Asthmatics had higher scores of NOT-S total and interview (p<0.05). Dysfunctions on sensory function and chewing and swallowing were more frequent in asthmatics (p<0.05). Salivary @entity3 AR on weekend was significantly higher for asthmatics (p<0.05). Salivary @entity3 @entity5 was significantly higher on weekday than weekend for controls (p<0.05). There were no significant differences in alpha-amylase values in and between groups. CONCLUSIONS: The presence of @entity2 in @entity0 was associated with @entity7 , negative perception of sensory, chewing and swallowing functions, and higher concentrations of salivary @entity3 on weekend.

title: Assessment of @entity7 , orthodontic treatment need, XXXX and salivary biomarkers in @entity4 @entity0 .

answer: @entity1


abstract: OBJECTIVE: To evaluate the @entity7 , malocclusions, @entity1 and salivary levels of @entity3 and alpha-amylase in @entity4 @entity0 . DESIGN: 108 7-9-yr-old @entity0 were selected from Policlinic Santa Teresinha Doutor Antonio Haddad Dib (asthmatics, n=53) and from public schools (controls, n=55), Piracicaba, SP, Brazil. Sleep @entity6 diagnosis was confirmed by parental report of grinding sounds and the presence of shiny and polish facets on incisors and/or first permanent molars. The index of orthodontic treatment need was used for occlusion evaluation. @entity1 were evaluated using the nordic orofacial test-screening (NOT-S). Salivary @entity3 and alpha-amylase were expressed as "awakening response" (AR), calculated as the difference between levels immediately after awakening and 30min after waking, and "diurnal decline" ( @entity5 ), calculated as the difference between levels at 30min after waking and at bedtime. Data were analyzed using Shapiro-Wilk/Kolmogorov-Smirnov, Chi-square, unpaired t test/Mann-Whitney and paired t/Wilcoxon tests. RESULTS: Sleep @entity6 was more prevalent in @entity0 with @entity2 than controls (47.2% vs. 27.3%, p<0.05). Asthmatics had higher scores of NOT-S total and interview (p<0.05). Dysfunctions on sensory function and chewing and swallowing were more frequent in asthmatics (p<0.05). Salivary @entity3 AR on weekend was significantly higher for asthmatics (p<0.05). Salivary @entity3 @entity5 was significantly higher on weekday than weekend for controls (p<0.05). There were no significant differences in alpha-amylase values in and between groups. CONCLUSIONS: The presence of @entity2 in @entity0 was associated with @entity7 , negative perception of sensory, chewing and swallowing functions, and higher concentrations of salivary @entity3 on weekend.

title: Assessment of @entity7 , orthodontic treatment need, @entity1 and salivary biomarkers in XXXX @entity0 .

answer: @entity4


abstract: OBJECTIVE: To evaluate the @entity7 , malocclusions, @entity1 and salivary levels of @entity3 and alpha-amylase in @entity4 @entity0 . DESIGN: 108 7-9-yr-old @entity0 were selected from Policlinic Santa Teresinha Doutor Antonio Haddad Dib (asthmatics, n=53) and from public schools (controls, n=55), Piracicaba, SP, Brazil. Sleep @entity6 diagnosis was confirmed by parental report of grinding sounds and the presence of shiny and polish facets on incisors and/or first permanent molars. The index of orthodontic treatment need was used for occlusion evaluation. @entity1 were evaluated using the nordic orofacial test-screening (NOT-S). Salivary @entity3 and alpha-amylase were expressed as "awakening response" (AR), calculated as the difference between levels immediately after awakening and 30min after waking, and "diurnal decline" ( @entity5 ), calculated as the difference between levels at 30min after waking and at bedtime. Data were analyzed using Shapiro-Wilk/Kolmogorov-Smirnov, Chi-square, unpaired t test/Mann-Whitney and paired t/Wilcoxon tests. RESULTS: Sleep @entity6 was more prevalent in @entity0 with @entity2 than controls (47.2% vs. 27.3%, p<0.05). Asthmatics had higher scores of NOT-S total and interview (p<0.05). Dysfunctions on sensory function and chewing and swallowing were more frequent in asthmatics (p<0.05). Salivary @entity3 AR on weekend was significantly higher for asthmatics (p<0.05). Salivary @entity3 @entity5 was significantly higher on weekday than weekend for controls (p<0.05). There were no significant differences in alpha-amylase values in and between groups. CONCLUSIONS: The presence of @entity2 in @entity0 was associated with @entity7 , negative perception of sensory, chewing and swallowing functions, and higher concentrations of salivary @entity3 on weekend.

title: Assessment of XXXX , orthodontic treatment need, @entity1 and salivary biomarkers in @entity4 @entity0 .

answer: @entity7


abstract: OBJECTIVE: To evaluate the @entity7 , malocclusions, @entity1 and salivary levels of @entity3 and alpha-amylase in @entity4 @entity0 . DESIGN: 108 7-9-yr-old @entity0 were selected from Policlinic Santa Teresinha Doutor Antonio Haddad Dib (asthmatics, n=53) and from public schools (controls, n=55), Piracicaba, SP, Brazil. Sleep @entity6 diagnosis was confirmed by parental report of grinding sounds and the presence of shiny and polish facets on incisors and/or first permanent molars. The index of orthodontic treatment need was used for occlusion evaluation. @entity1 were evaluated using the nordic orofacial test-screening (NOT-S). Salivary @entity3 and alpha-amylase were expressed as "awakening response" (AR), calculated as the difference between levels immediately after awakening and 30min after waking, and "diurnal decline" ( @entity5 ), calculated as the difference between levels at 30min after waking and at bedtime. Data were analyzed using Shapiro-Wilk/Kolmogorov-Smirnov, Chi-square, unpaired t test/Mann-Whitney and paired t/Wilcoxon tests. RESULTS: Sleep @entity6 was more prevalent in @entity0 with @entity2 than controls (47.2% vs. 27.3%, p<0.05). Asthmatics had higher scores of NOT-S total and interview (p<0.05). Dysfunctions on sensory function and chewing and swallowing were more frequent in asthmatics (p<0.05). Salivary @entity3 AR on weekend was significantly higher for asthmatics (p<0.05). Salivary @entity3 @entity5 was significantly higher on weekday than weekend for controls (p<0.05). There were no significant differences in alpha-amylase values in and between groups. CONCLUSIONS: The presence of @entity2 in @entity0 was associated with @entity7 , negative perception of sensory, chewing and swallowing functions, and higher concentrations of salivary @entity3 on weekend.

title: Assessment of @entity7 , orthodontic treatment need, @entity1 and salivary biomarkers in @entity4 XXXX .

answer: @entity0


abstract: Increased sensitivity to a fast with rapid onset of @entity6 , hypoalaninemia, and @entity9 is characteristic of @entity1 and @entity0 gestation. The present study examines the role of sex @entity3 in the development of these metabolic changes. Subgroups of female rate received 10 microgram of @entity2 (E), 10 mg of @entity7 (P), or the two in combination (E + P) s.c. daily for 5 days. Control @entity1 (C) received @entity10 oil alone. Different groups were starved 12, 24 and 48 hr during days 4 and 5 or treatment. Plasma substrate and insulin responses were measured and compared to results of similar studies performed on @entity1 in late gestation. Administration of E or P along had no significant effects on measured parameters as compared to control values. However, the combined E + P regimen resulted in significantly higher @entity6 , greater hypoalaninemia, and relatively higher @entity4 concentrations than in control groups during fasting. Plasma @entity4 , free @entity5 , and @entity11 concentrations in the pregnant group exceeded values of both the E + P and control animals. However, plasma free @entity8 in the E + P group were significantly lower as compared to control values during starvation. These data suggest that the combined effects of @entity2 and @entity7 enhance ketogenesis and hypoalaninemia independent of the fetal-placental unit during starvation in pregnancy. Since the ketogenic effect was associated with a relative suppression of plasma free @entity8 , this may be indicative of a direct action of these hormones on hepatic disposition of free @entity8 and/or the biosynthetic pathways for @entity11 body production.

title: Metabolic response to starvation. I. Relative effects of pregnancy and sex steroid administration in the XXXX .

answer: @entity1


abstract: A 70 year-old @entity0 visited our hospital complaining of macrohematuria. She had undergone augmentation ileocystoplasty for @entity5 50 years previously. CT and cystoscopy showed @entity1 at the ileovesical @entity3 . She underwent a partial cystectomy. The pathological diagnosis was @entity4 of the ileal segment. Recurrence was observed with rapid progression. The @entity0 died 8 months after the operation. In Japanese literature, 43 cases of @entity2 arising in augumented bladder have been reported. Average period to the diagnosis of the @entity1 from the ileocystoplasty @entity6 years. The period of our case was 50 years, the longest in 43 cases.

title: [ XXXX arising in an ileum segment of Scheele's ring 50 years after cystoplasty].

answer: @entity4


abstract: PURPOSE: @entity5 ( @entity5 ) affects over one-third of adults and is the leading cause of overall mortality and morbidity. @entity3 ( @entity8 ) is widely used in the prevention of @entity5 . As the population continues to mature, the number of @entity0 presenting for spinal surgery that are under @entity8 treatment is rising. Studies investigating the outcome of lumbar spine surgeries without discontinuation of @entity8 therapy are lacking. The purpose of this study is to evaluate the peri- and @entity2 and @entity1 rates of @entity0 undergoing non-instrumented, extradural, lumbar spine surgery with or without discontinuation of low-dose @entity8 . METHODS: We retrospectively compared the intra- and postoperative @entity4 , morbidity, mortality, blood transfusion requirements and hematologic findings in the @entity8 group (40 @entity0 ) and the control group (62 @entity0 ). The diagnosis in all @entity0 was either @entity6 . RESULTS: Intraoperative @entity4 was 221  ml in the @entity8 group and 140.16  ml in the control group, showing no statistical difference (p  =  0.08). @entity2 was 146.58 and 167.97  ml in the @entity8 and control groups, respectively, also without statistical difference (p  =  0.76). In the @entity8 group one @entity0 developed a @entity2 needing revision surgery, while in the control group no postoperative epidural @entity7 were seen (p  =  0.40). In addition, blood transfusion requirements, hematologic findings, morbidity and mortality showed no significant difference. CONCLUSION: The continuation of @entity8 treatment in @entity0 undergoing non-instrumented extradural lumbar spinal surgery seems to be safe and its perioperative continuation might therefore be recommended. Further studies confirming these results are needed.

title: Non-instrumented extradural lumbar spine surgery under low-dose XXXX : a comparative risk analysis study.

answer: @entity3


abstract: BACKGROUND: Renal transplantation is the treatment of choice for @entity0 with @entity5 . The renal transplant recipients are susceptible to a variety of @entity2 such as infections, @entity6 , and @entity1 . OBJECTIVES: We aimed to determine the frequency of pathological lesions in GI endoscopic biopsies in recipients of live related renal transplantation in our setting. METHODS: This retrospective survey was carried out at Histopathology Department of Sindh Institute of Urology and Transplantation, Karachi, from December 2010 to January 2011. All consecutive renal transplant @entity0 of all ages and both genders on regular follow up, presenting with @entity2 and in whom GI endoscopic biopsies were performed, were included. The demographic, clinical, and laboratory data were retrieved from case files and the pathological diagnoses from the original biopsy reports. RESULTS: A total of 200 consecutive renal transplant @entity0 were enrolled. The biopsies comprised of 19 (9.5  %) esophageal biopsies, 119 (59.5  %) gastric biopsies, 148 (74  %) duodenal biopsies, and 66 (33  %) colorectal biopsies. The main pathological lesions included @entity9 in 22 (11  %) of all @entity0 , @entity8 in 11 (9.2  %) of gastric biopsies, cryptosporidium in 4 (1.6  %), @entity10 in 30 (15  %), @entity11 in 5 (3.4  %), @entity12 in 33 (15  %), @entity4 in 3 (2  %) of the small intestinal biopsies, and @entity3 in 1 (1.7  %) gastric biopsy. CONCLUSION: A wide spectrum of pathological lesions including @entity7 was seen in GI endoscopic biopsies in renal transplant @entity0 . Endoscopic biopsies play an important role in the diagnosis and management of @entity2 in renal transplant @entity0 .

title: XXXX in renal transplant recipients detected by endoscopic biopsies in a developing country.

answer: @entity2


abstract: BACKGROUND: Previous studies have reported significant @entity1 among individuals along the @entity7 ( @entity7 ) spectrum. The basis of @entity2 is still poorly understood and explicit (emotion appraisal) and implicit (autonomic system activity) responses have not been carefully evaluated. OBJECTIVE: We investigated explicit evaluation of emotions by testing valence and arousal using self-report measures and we also assessed automatic responses to emotional cues, using autonomic measures (skin conductance response and heart rate). METHODS: 16 @entity3 and 12 agrammatic variants of primary progressive @entity6 @entity0 were included. The performance of these @entity0 was compared to a group of 14 @entity0 with @entity5 and 20 healthy controls. Each subject was required to observe and evaluate affective pictures while autonomic parameters were recorded. RESULTS: @entity7 @entity0 preserved a functional general competency in terms of valence (correct positive versus negative attribution) and arousal (correct dichotomy between high versus low arousal category) distinction. These @entity0 showed significant changes in autonomic implicit response compared to the other groups. The mismatch between explicit and implicit responsiveness to emotional cues was found both in @entity3 and in agrammatic variants of primary progressive @entity6 . Emotional responsiveness was related to the severity of @entity3 as measured by the Frontal Behavioral Inventory and associated with @entity4 of the left putamen. CONCLUSION: The present findings indicate that @entity7 @entity0 are able to explicitly "appraise" the emotion, but they cannot implicitly "feel" the emotion. This mismatch between the two levels may help explain the general emotional behavior impairment found in these @entity0 .

title: Understanding Emotions in XXXX : The Explicit and Implicit Emotional Cue Mismatch.

answer: @entity7


abstract: AIMS: To assess adherence to the UK's National Institute for Health and Care Excellence (NICE) guidelines for initiating and continuing @entity5 ( @entity6 agonists in @entity0 with @entity3 2 @entity1 (T2DM). RESEARCH DESIGN AND METHODS: A retrospective cohort study of 7133 primary care @entity0 >= 40 years with a first prescription for a @entity6 agonist following publication of NICE guideline/guidance. @entity0 characteristics and levels of clinical monitoring were assessed using descriptive analyses. MAIN OUTCOME MEASURES: Main outcomes were the proportion of @entity0 initiating @entity6 agonists as part of NICE-recommended dual- or triple-therapy regimens; the proportions meeting NICE triple therapy initiation criteria (glycosylated hemoglobin [HbA1c] >= 7.5% and body mass index [BMI] >= 35   kg/m(2)) and the proportions continuing @entity6 agonist at 6 months according to NICE recommendations. RESULTS: Mean age at initiating @entity6 agonists was 58.2 years (SD 9.4), BMI 38.4   kg/m(2) (SD 6.8) and HbA1c 9.2% (SD 3.2%). Overall, only 25% of @entity0 initiated @entity6 agonists as part of a NICE-recommended regimen. Of @entity0 initiated on a recommended triple-therapy regimen, 50% (646/1284) fulfilled both NICE HbA1c and BMI initiation criteria. Approximately 18% (32/174) of @entity0 continuing NICE-recommended dual therapy at 6 months achieved a 1% reduction in @entity4 c and 6.4% (33/515) continuing with NICE-recommended triple therapy achieved NICE's target reductions for both HbA1c and body weight. About 8% of @entity0 continuing exenatide as triple therapy (N   =   243) achieved both targets. CONCLUSIONS: Adherence to NICE guidance for initiating and continuing @entity6 agonists is low. However, lack of data on ethnicity (for assessing NICE's BMI criteria) and on contraindications and/or @entity2 to other @entity1 medication in the treatment pathway have limited our ability to fully assess adherence to @entity5 prescribing. Further research is warranted to better understand general practitioners' prescribing decisions given the cost of prescribing @entity6 agonists.

title: Adherence to NICE guidance on XXXX receptor agonists among @entity0 with @entity1 : an evaluation using the Clinical Practice Research Datalink.

answer: @entity5


abstract: AIMS: To assess adherence to the UK's National Institute for Health and Care Excellence (NICE) guidelines for initiating and continuing @entity5 ( @entity6 agonists in @entity0 with @entity3 2 @entity1 (T2DM). RESEARCH DESIGN AND METHODS: A retrospective cohort study of 7133 primary care @entity0 >= 40 years with a first prescription for a @entity6 agonist following publication of NICE guideline/guidance. @entity0 characteristics and levels of clinical monitoring were assessed using descriptive analyses. MAIN OUTCOME MEASURES: Main outcomes were the proportion of @entity0 initiating @entity6 agonists as part of NICE-recommended dual- or triple-therapy regimens; the proportions meeting NICE triple therapy initiation criteria (glycosylated hemoglobin [HbA1c] >= 7.5% and body mass index [BMI] >= 35   kg/m(2)) and the proportions continuing @entity6 agonist at 6 months according to NICE recommendations. RESULTS: Mean age at initiating @entity6 agonists was 58.2 years (SD 9.4), BMI 38.4   kg/m(2) (SD 6.8) and HbA1c 9.2% (SD 3.2%). Overall, only 25% of @entity0 initiated @entity6 agonists as part of a NICE-recommended regimen. Of @entity0 initiated on a recommended triple-therapy regimen, 50% (646/1284) fulfilled both NICE HbA1c and BMI initiation criteria. Approximately 18% (32/174) of @entity0 continuing NICE-recommended dual therapy at 6 months achieved a 1% reduction in @entity4 c and 6.4% (33/515) continuing with NICE-recommended triple therapy achieved NICE's target reductions for both HbA1c and body weight. About 8% of @entity0 continuing exenatide as triple therapy (N   =   243) achieved both targets. CONCLUSIONS: Adherence to NICE guidance for initiating and continuing @entity6 agonists is low. However, lack of data on ethnicity (for assessing NICE's BMI criteria) and on contraindications and/or @entity2 to other @entity1 medication in the treatment pathway have limited our ability to fully assess adherence to @entity5 prescribing. Further research is warranted to better understand general practitioners' prescribing decisions given the cost of prescribing @entity6 agonists.

title: Adherence to NICE guidance on @entity5 receptor agonists among @entity0 with XXXX : an evaluation using the Clinical Practice Research Datalink.

answer: @entity1


abstract: AIMS: To assess adherence to the UK's National Institute for Health and Care Excellence (NICE) guidelines for initiating and continuing @entity5 ( @entity6 agonists in @entity0 with @entity3 2 @entity1 (T2DM). RESEARCH DESIGN AND METHODS: A retrospective cohort study of 7133 primary care @entity0 >= 40 years with a first prescription for a @entity6 agonist following publication of NICE guideline/guidance. @entity0 characteristics and levels of clinical monitoring were assessed using descriptive analyses. MAIN OUTCOME MEASURES: Main outcomes were the proportion of @entity0 initiating @entity6 agonists as part of NICE-recommended dual- or triple-therapy regimens; the proportions meeting NICE triple therapy initiation criteria (glycosylated hemoglobin [HbA1c] >= 7.5% and body mass index [BMI] >= 35   kg/m(2)) and the proportions continuing @entity6 agonist at 6 months according to NICE recommendations. RESULTS: Mean age at initiating @entity6 agonists was 58.2 years (SD 9.4), BMI 38.4   kg/m(2) (SD 6.8) and HbA1c 9.2% (SD 3.2%). Overall, only 25% of @entity0 initiated @entity6 agonists as part of a NICE-recommended regimen. Of @entity0 initiated on a recommended triple-therapy regimen, 50% (646/1284) fulfilled both NICE HbA1c and BMI initiation criteria. Approximately 18% (32/174) of @entity0 continuing NICE-recommended dual therapy at 6 months achieved a 1% reduction in @entity4 c and 6.4% (33/515) continuing with NICE-recommended triple therapy achieved NICE's target reductions for both HbA1c and body weight. About 8% of @entity0 continuing exenatide as triple therapy (N   =   243) achieved both targets. CONCLUSIONS: Adherence to NICE guidance for initiating and continuing @entity6 agonists is low. However, lack of data on ethnicity (for assessing NICE's BMI criteria) and on contraindications and/or @entity2 to other @entity1 medication in the treatment pathway have limited our ability to fully assess adherence to @entity5 prescribing. Further research is warranted to better understand general practitioners' prescribing decisions given the cost of prescribing @entity6 agonists.

title: Adherence to NICE guidance on @entity5 receptor agonists among XXXX with @entity1 : an evaluation using the Clinical Practice Research Datalink.

answer: @entity0


abstract: BACKGROUND: Topical @entity3 is becoming essential as the number of invasive screening procedures involving @entity0 rises steadily. Little is known about the frequency of these procedures, or about interventions to ease the @entity2 . METHODS: We investigated the use of EMLA cream in 184 school-aged @entity0 in KwaZulu-Natal Province, South Africa. Another group of 20 @entity0 did not receive any local @entity3 and was assessed as a control. Anticipatory @entity1 , @entity2 , adverse reactions and ease of procedure were assessed using a subjective visual analogue scale (VAS) @entity2 score generated by the researcher and obtained from each @entity0 immediately after the procedure. RESULTS: The use of EMLA cream resulted in reduced @entity2 and distress. The @entity2 -relieving influence of EMLA was good (91.3% analgesic effect). @entity0 who received EMLA cream reported significantly lower VAS @entity2 scores (p=0.001). @entity2 scores generated by the researcher were also significantly lower in the EMLA group than in the control group (p=0.000). No adverse reactions were observed, and the @entity0 could continue with other research activities during the application time and after the procedure. Parent or caregiver scores were in favour of EMLA cream. CONCLUSION: EMLA cream was safe and effective for alleviating the @entity2 associated with venepuncture in a fieldwork setting. We therefore believe that it merits a place in the routine premedication of @entity0 before phlebotomy and cannulation procedures in clinical settings, research studies and field surveys. Further research is recommended to assess whether EMLA cream can be used for immunisations.

title: Use of EMLA cream as a topical anaesthetic before venepuncture procedures in field surveys: A practice that helps XXXX , parents and health professionals.

answer: @entity0


abstract: OBJECTIVE: There appears to be an optimal point in balancing the relative benefits of extending the resuscitation time to obtain return of spontaneous circulation in the prehospital setting and the initiation of therapies such as extracorporeal cardiopulmonary resuscitation (CPR). This study investigated how prehospital CPR duration is related to survival and neurologic outcome in @entity2 ( @entity2 ) and tried to find the tolerable time for prehospital resuscitation. MATERIALS AND METHODS: Out-of-hospital @entity1 @entity0 with @entity2 in Funabashi City, Japan, from January 2009 to December 2013 were reviewed. Resuscitation teams that included physicians were dispatched to incident sites. Survival rate at 24 hours and neurologic outcome at 30 days were analyzed with respect to prehospital CPR duration. RESULTS: A total of 172 @entity0 were evaluated. Seventy-three @entity0 were alive at 24 hours. Thirty-four @entity0 had favorable neurologic outcomes after 30 days. Of the 69 @entity0 who required prolonged prehospital CPR (>30 minutes), 6 were alive at 24 hours, and only 1 had a favorable neurologic outcome at 30 days. Logistic regression model showed that both survival rate at 24 hours and neurologic outcome at 30 days deteriorated with the increase in prehospital CPR duration (both P < .001). CONCLUSION: The prognosis of out-of-hospital @entity1 @entity0 with @entity2 deteriorated with the increase in prehospital CPR duration. Favorable results are less likely especially in cases of prolonged prehospital CPR (>30 minutes). Therefore, it may be necessary to consider transportation to a more definitive treatment facility rather than extending conventional CPR in the prehospital setting.

title: Relationship between duration of prehospital resuscitation and favorable prognosis in XXXX .

answer: @entity2


abstract: The authors report their experience in laparoscopic repair of @entity1 in @entity0 . From May 2010 to November 2013, 122 @entity0 with @entity1 underwent laparoscopic herniorrhaphy (92 males and 30 females). Telescope used was 5 mm, while trocars for the operative instruments were 3 or 2 mm. After introducing the camera at the umbilical level and trocars in triangulation, a 4-0 nonabsorbable monofilament suture was inserted directly through the abdominal wall. The internal inguinal ring was then closed by N or double N suture. All operations were performed in one-day surgery setting. In the case of association of inguinal and @entity3 an original technique was performed for positioning and fixing the umbilical trocar and for the primary closure of the abdominal wall defect. The postoperative follow-up consisted of outpatient visits at 1 week and 1, 3, and 6 months. The mean age of @entity0 was 38.5 months. Of all @entity0 , 26 were also suffering from @entity3 (19 males and 7 females). A total of 160 herniorrhaphies were performed; 84 were unilateral (66 @entity1 , 18 @entity1 associated with @entity3 ), 38 bilateral (30 @entity1 associated with @entity3 ). Nine of 122 @entity0 (6 males and 3 females) were operated in emergency for @entity2 . A pre-operative diagnosis of @entity1 was performed in 106 cases. Of these @entity0 , laparoscopy revealed a controlateral open internal inguinal ring in 22 cases (20.7%). The mean operative time was 29.9  15.9 min for the monolateral herniorrhaphies, while in case of bilateral repair the mean operative time was 41.5  10.4 min. The mean operative time for the repair of @entity1 associated with @entity3 was 30.1  7.4 while for the correction of bilateral @entity1 associated with @entity3 39.5  10.6 min. There were 3 recurrences (1.8%): 2 cases in unilateral repair and 1 case a unilateral recurrence in a bilateral repair. No other complications were seen. Laparoscopic repair of @entity1 in @entity0 performed in this experience resulted a safe and effective procedure.

title: Laparoscopic herniorrhaphy in XXXX .

answer: @entity0


abstract: @entity4 is a malignancy of the mesenchymal tissue derived from transformed cells that produce the cartilage matrix. In the neck area, it represents less than 0.5% of @entity2 pathology. @entity4 of the hyoid bone is extremely rare, only 20 cases having been published so far (PubMed 2014). We present the case of a 30-year-old @entity0 from the urban area, admitted in the ENT (Ear, Nose _ Throat) Emergency Service with @entity7 , @entity6 , stomatolalia, with evolutive and progressive clinical history of 2-3 months. Endoscopic examination revealed a @entity2 process located in the right vallecula, who by mass effect displaces the above-hyoid @entity8 . CT (computerized tomography) scan described a cervical @entity2 aspect, with multiple septae and inside calcifications with a diameter of 3-4 mm. Surgery consisted in removal of the @entity2 process together with the hyoid bone. Histopathological and especially immunohistochemical examination established the diagnosis of @entity3 of the hyoid bone. For assessment of the phenotype of the @entity2 cells, the following immunohistochemical markers were used: @entity5 , Ki67. The @entity0 followed radiochemotherapic oncological treatment and returned for regular follow-ups. There was a positive development with no signs of regional or remote relapse or @entity1 for 24 months after surgical treatment. Surgery is the treatment of @entity2 , with chemoradiation playing an adjuvant role. Regular tracking of the @entity0 is mandatory.

title: XXXX of the hyoid bone: a case report.

answer: @entity4


abstract: OBJECTIVE: The Illinois Department of Public Health mandated that all clinicians who provide care to @entity3 @entity0 participate in the Illinois @entity2 Project. The aim of the current report is to describe change in knowledge among providers engaged in the project, as assessed by pre- and post-tests. METHODS: The project, implemented 2008 to 2010, included four components: a written 25-item multiple-choice examination (pre-test), a didactic lecture, skill stations (for teaching @entity1 estimation), and a simulation drill and debriefing. @entity0 completed a post-test 6 months later. Pre- and post-test examination scores were compared. RESULTS: Data from 95 hospitals are included in this analysis (9456 paired test results). The proportion of @entity0 who scored >= 88% correct answers increased from 10.9% on the pre-test to 49.1% on the post-test (p   <   0.0001). Registered nurses made greater improvements in test scores than anesthesia and @entity3 providers (p   <   0.0001). CONCLUSIONS: The Illinois @entity2 Project was successful in improving knowledge of @entity2 in a large number of providers with different expertise and experience levels. Further long-term study is essential to determine whether the skills acquired during the Project contribute to improved @entity2 outcomes for the @entity0 of Illinois.

title: The state of Illinois XXXX project: pre-project and post-training examination scores.

answer: @entity2


abstract: Thirteen @entity0 with @entity6 consecutive to radiotherapy for @entity4 were operated upon between 1973 and 1979. The small bowel was involved in 9 @entity0 and the colon and rectum in 4 @entity0 . Urinary tract lesions were associated in 3 @entity0 of each group. Intestinal @entity2 , progression of the lesions and extensive pelvic @entity3 were the only criteria of poor prognosis. Twenty-two operations were performed: 4 for urinary tract lesions and 18 for @entity6 . Five @entity0 died during the immediate post-operative period and five died within 2 to 30 months after surgery, including 4 whose @entity4 recurred. The operative technique should be selected according to the extent and severity of radiation-induced damage, as determined by pre-operative examination and thorough exploration of the abdominal cavity once opened. Limited lesions of the small bowel can be treated by resection, but intestinal bypass with latero-lateral @entity5 seems to be preferable in cases with extensive lesions. @entity0 with @entity1 should have defunctioning colostomy prior to any other procedure dictated by the state of affairs. Multiple @entity5 , extensive resections and excessive dissections should be avoided.

title: [Radiation-induced XXXX . Prognosis and surgical management (author's transl)].

answer: @entity6


abstract: Corpus @entity2 is a common gynecologic cause for hemoperitoneum. Recent sexual intercourse is usually a preceding factor. However, @entity6 without evident @entity1 or @entity1 is rarely reported. We present a 34-year-old female who presented to the emergency department with severe bilateral lower quadrant @entity3 after sexual intercourse. CT of the abdomen and pelvis revealed an @entity5 with extravasation of contrast questionable to be from one of the branches of the left internal iliac artery, and no @entity7 . Left internal iliac artery angiogram was performed and revealed no active extravasation. Exploratory laparotomy was performed and revealed an actively bleeding left @entity0 area that was repaired and biopsied. No evidence of cysts was observed. Histopathological examination revealed a @entity4 . Suspicion for corpus @entity2 as a cause of @entity6 should be maintained despite nonevidence of cysts on CT or intraoperatively.

title: @entity6 caused by XXXX : a hidden etiology.

answer: @entity2


abstract: Corpus @entity2 is a common gynecologic cause for hemoperitoneum. Recent sexual intercourse is usually a preceding factor. However, @entity6 without evident @entity1 or @entity1 is rarely reported. We present a 34-year-old female who presented to the emergency department with severe bilateral lower quadrant @entity3 after sexual intercourse. CT of the abdomen and pelvis revealed an @entity5 with extravasation of contrast questionable to be from one of the branches of the left internal iliac artery, and no @entity7 . Left internal iliac artery angiogram was performed and revealed no active extravasation. Exploratory laparotomy was performed and revealed an actively bleeding left @entity0 area that was repaired and biopsied. No evidence of cysts was observed. Histopathological examination revealed a @entity4 . Suspicion for corpus @entity2 as a cause of @entity6 should be maintained despite nonevidence of cysts on CT or intraoperatively.

title: XXXX caused by @entity2 : a hidden etiology.

answer: @entity6


abstract: PURPOSE: To measure changes in upper limb work and power capacity before and after anterior scalene @entity1 (ASMB) to suggest @entity2 caused by costoclavicular space compression. METHODS: We evaluated 34 @entity0 disabled by symptoms suggesting @entity2 . An ASMB was performed via a supraclavicular injection. The sternocleidomastoid muscle was injected as a control. We captured data obtained from work simulator measurements before and after ASMB. Each @entity0 performed a push-pull test with the forearm at waist level ( @entity5 ), an overhead bar push-pull test with the arm elevated (test 2), and the extremity abduction stress test with repetitive hand gripping during static arm elevation (test 3). We measured the work product, time to fatigue, and power generation. Sensory testing was performed after ASMB to rule out improved performance associated with possible @entity3 . RESULTS: In contrast to sternocleidomastoid injection controls, symptomatic and functional improvement was noted in all @entity0 (n  = 34) after ASMB. Work product measurement improved 93%, 108%, and 104% for tests 1, 2, and 3, respectively. @entity4 also increased after the block. CONCLUSIONS: Temporary symptomatic improvement after ASMB may be anticipated in @entity0 with TOS. This study documents a significant concurrent increase in upper limb motor function after the block. Increased work and power measurements after ASMB may draw diagnostic inference regarding a dynamic change in the scalene muscle and the costoclavicular space associated with symptomatic @entity2 . TYPE OF STUDY/LEVEL OF EVIDENCE: Diagnostic III.

title: Quantitative Assessment of Scalene Muscle Block  for the Diagnosis of Suspected XXXX .

answer: @entity2


abstract: AIM: We observed a layer between @entity1 activity and background on FDG PET/CT with the 10-step colour scale and the window level set properly. We named the layer peritumoral halo layer (PHL). We performed this study to establish the reliability of metabolic @entity1 volume (MTV) segmentation using PHL (MTVPHL) in @entity0 with @entity4 . @entity0 , METHODS: Of a total of 140 @entity4 ( @entity4 ) @entity0 , 70 (50.0%) had FDG-avid @entity4 . In these @entity0 , MTVPHL, MTV segmented according to fixed 50% SUVmax (MTV50%), and fixed SUV with 2.5 to 4.0 (MTV2.5 to MTV4.0) were compared with pathologic @entity1 volume ( @entity3 ). The absolute percentage difference between MTVPHL and @entity3 was compared in @entity2 (MPTC) and @entity2 (non-MPTC) subgroups. The % SUVmax and SUV thresholds of MTVPHL were compared with @entity1 SUVmax. RESULTS: Among the MTVs, MTV50% was not correlated with @entity3 (r = -0.16, p = 0.182) and was not reliable according to the Bland-Altman plot. Although MTV2.5, MTV3.0, MTV3.5, and MTV4.0 correlated with @entity3 (r = 0.85, 0.86, 0.87, and 0.87, respectively; p < 0.001), these MTVs were not reliable on Bland-Altman analyses. MTVPHL was significantly correlated with @entity3 (r = 0.80, p < 0.001), and the Bland-Altman plot did not show systemic error. The MTVPHL was more accurate in non-MPTC than in MPTC (p < 0.001), and the absolute % difference was smaller as @entity3 became larger (   = -0.65, p < 0.001). The MTVPHL thresholds had correlations with SUVmax (% SUVmax threshold:    = -0.87, p < 0.001; SUV threshold: r = 0.88, p < 0.001). CONCLUSIONS: MTVPHL was more reliable than MTV%SUVmax or MTVSUV. The reliability of MTVPHL improved with larger PTVs. The threshold of the MTVPHL was naturally altered by PHL according to SUVmax.

title: A new method for segmentation of FDG PET metabolic XXXX volume using the peritumoural halo layer and a 10-step colour scale. A study in @entity0 with @entity4 .

answer: @entity1


abstract: AIM: We observed a layer between @entity1 activity and background on FDG PET/CT with the 10-step colour scale and the window level set properly. We named the layer peritumoral halo layer (PHL). We performed this study to establish the reliability of metabolic @entity1 volume (MTV) segmentation using PHL (MTVPHL) in @entity0 with @entity4 . @entity0 , METHODS: Of a total of 140 @entity4 ( @entity4 ) @entity0 , 70 (50.0%) had FDG-avid @entity4 . In these @entity0 , MTVPHL, MTV segmented according to fixed 50% SUVmax (MTV50%), and fixed SUV with 2.5 to 4.0 (MTV2.5 to MTV4.0) were compared with pathologic @entity1 volume ( @entity3 ). The absolute percentage difference between MTVPHL and @entity3 was compared in @entity2 (MPTC) and @entity2 (non-MPTC) subgroups. The % SUVmax and SUV thresholds of MTVPHL were compared with @entity1 SUVmax. RESULTS: Among the MTVs, MTV50% was not correlated with @entity3 (r = -0.16, p = 0.182) and was not reliable according to the Bland-Altman plot. Although MTV2.5, MTV3.0, MTV3.5, and MTV4.0 correlated with @entity3 (r = 0.85, 0.86, 0.87, and 0.87, respectively; p < 0.001), these MTVs were not reliable on Bland-Altman analyses. MTVPHL was significantly correlated with @entity3 (r = 0.80, p < 0.001), and the Bland-Altman plot did not show systemic error. The MTVPHL was more accurate in non-MPTC than in MPTC (p < 0.001), and the absolute % difference was smaller as @entity3 became larger (   = -0.65, p < 0.001). The MTVPHL thresholds had correlations with SUVmax (% SUVmax threshold:    = -0.87, p < 0.001; SUV threshold: r = 0.88, p < 0.001). CONCLUSIONS: MTVPHL was more reliable than MTV%SUVmax or MTVSUV. The reliability of MTVPHL improved with larger PTVs. The threshold of the MTVPHL was naturally altered by PHL according to SUVmax.

title: A new method for segmentation of FDG PET metabolic @entity1 volume using the peritumoural halo layer and a 10-step colour scale. A study in @entity0 with XXXX .

answer: @entity4


abstract: AIM: We observed a layer between @entity1 activity and background on FDG PET/CT with the 10-step colour scale and the window level set properly. We named the layer peritumoral halo layer (PHL). We performed this study to establish the reliability of metabolic @entity1 volume (MTV) segmentation using PHL (MTVPHL) in @entity0 with @entity4 . @entity0 , METHODS: Of a total of 140 @entity4 ( @entity4 ) @entity0 , 70 (50.0%) had FDG-avid @entity4 . In these @entity0 , MTVPHL, MTV segmented according to fixed 50% SUVmax (MTV50%), and fixed SUV with 2.5 to 4.0 (MTV2.5 to MTV4.0) were compared with pathologic @entity1 volume ( @entity3 ). The absolute percentage difference between MTVPHL and @entity3 was compared in @entity2 (MPTC) and @entity2 (non-MPTC) subgroups. The % SUVmax and SUV thresholds of MTVPHL were compared with @entity1 SUVmax. RESULTS: Among the MTVs, MTV50% was not correlated with @entity3 (r = -0.16, p = 0.182) and was not reliable according to the Bland-Altman plot. Although MTV2.5, MTV3.0, MTV3.5, and MTV4.0 correlated with @entity3 (r = 0.85, 0.86, 0.87, and 0.87, respectively; p < 0.001), these MTVs were not reliable on Bland-Altman analyses. MTVPHL was significantly correlated with @entity3 (r = 0.80, p < 0.001), and the Bland-Altman plot did not show systemic error. The MTVPHL was more accurate in non-MPTC than in MPTC (p < 0.001), and the absolute % difference was smaller as @entity3 became larger (   = -0.65, p < 0.001). The MTVPHL thresholds had correlations with SUVmax (% SUVmax threshold:    = -0.87, p < 0.001; SUV threshold: r = 0.88, p < 0.001). CONCLUSIONS: MTVPHL was more reliable than MTV%SUVmax or MTVSUV. The reliability of MTVPHL improved with larger PTVs. The threshold of the MTVPHL was naturally altered by PHL according to SUVmax.

title: A new method for segmentation of FDG PET metabolic @entity1 volume using the peritumoural halo layer and a 10-step colour scale. A study in XXXX with @entity4 .

answer: @entity0


abstract: UNASSIGNED: @entity10 ( @entity10 ) is an aggressive @entity1 of mesothelial cells of pleural and peritoneal cavities. In 85% of cases both @entity10 is caused by @entity8 exposure. Although both are @entity8 -induced @entity1 , the incidence of @entity10 is significantly higher (85%) than peritoneal @entity10 (15%). It has been proposed that @entity3 is a result of @entity8 -induced @entity2 but it is not clear what contributes to the differences observed between incidences of these two @entity1 . We hypothesize that the observed differences in incidences of @entity10 are the result of differences in the direct response of these cell types to @entity8 rather than to differences mediated by the in vivo microenvironment. To test this hypothesis we characterized cellular responses to @entity8 in a controlled environment. We found significantly greater changes in genome-wide expression in response to @entity8 exposure in pleural mesothelial cells as compared to peritoneal mesothelial cells. In particular, a greater response in many common genes ( @entity5 , @entity14 , @entity11 , @entity12 , @entity4 , @entity0 ) was seen in pleural mesothelial cells as compared to peritoneal mesothelial cells. Unique genes expressed in pleural mesothelial cells were mainly pro-inflammatory ( @entity7 , @entity9 , @entity6 , @entity13 ) and have previously been shown to be involved in development of @entity10 . Our results are consistent with the hypothesis that differences in incidences of @entity10 upon exposure to @entity8 are the result of differences in mesothelial cell physiology that lead to differences in the inflammatory response, which leads to @entity1 . J. Cell. Biochem. 116: 1540-1552, 2015.    2015 Wiley Periodicals, Inc.

title: Differential Susceptibility of XXXX Pleural and Peritoneal Mesothelial Cells to Asbestos Exposure.

answer: @entity0


abstract: OBJECTIVE: To compare femoral access site closure techniques and to highlight risk factors for puncture site complications after @entity4 . METHODS: This retrospective study included 787 @entity0 . Procedures were performed according to a standardized protocol. Puncture site complications within 24 hours were regarded as study end points. RESULTS: Ninety (11.5%) puncture site complications were registered. Conventional manual compression (n = 87, 11.1%) was significantly associated with puncture site complications (odds ratio [OR] 2.08, P = .03). Body mass index > 25 kg/m(2) (OR 0.54, P = .01) and prothrombin time > 70% (OR 0.38, P = .04) were protective. All @entity3 occurred in procedures >45 minutes. Blood pressure >200 mm Hg and below the knee (BTK) procedures were strong predictors for access site complications (OR 4.21, P = .01 and OR 3.33, P = .02). CONCLUSIONS: We observed an inferiority of conventional manual compression. Age, procedure duration > 45 minutes, BTK procedures, uncontrolled @entity2 , and @entity1 were risk factors.

title: Risk Factors for Puncture Site Complications After Endovascular Procedures in XXXX With Peripheral Arterial Disease.

answer: @entity0


abstract: PURPOSE: To evaluate and compare the performance of a point-source color light-emitting diode (LED)-based topographer (color-LED) in measuring anterior corneal power and aberrations with that of a Placido-disk topographer and a combined Placido and dual Scheimpflug device. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas USA. DESIGN: Retrospective observational case series. METHODS: Normal eyes and post-refractive-surgery eyes were consecutively measured using color-LED, Placido, and dual-Scheimpflug devices. The main outcome measures were anterior corneal power, @entity1 , and higher-order aberrations (HOAs) (6.0 mm pupil), which were compared using the t test. RESULTS: There were no statistically significant differences in corneal power measurements in normal and post-refractive surgery eyes and in @entity1 magnitude in post-refractive surgery eyes between the color-LED device and Placido or dual Scheimpflug devices (all P > .05). In normal eyes, there were no statistically significant differences in 3rd-order @entity0 and 4th-order spherical aberration between the color-LED and Placido devices and in HOA root mean square, 3rd-order @entity0 , 3rd-order trefoil, 4th-order spherical aberration, and 4th-order secondary @entity1 between the color-LED and dual Scheimpflug devices (all P > .05). In post-refractive surgery eyes, the color-LED device agreed with the Placido and dual-Scheimpflug devices regarding 3rd-order @entity0 and 4th-order spherical aberration (all P > .05). CONCLUSIONS: In normal and post-refractive surgery eyes, all 3 devices were comparable with respect to corneal power. The agreement in corneal aberrations varied. FINANCIAL DISCLOSURE: Drs. Wang, Koch, and Weikert are consultants to Ziemer Ophthalmic Systems AG. Dr. Koch is a consultant to Abbott Medical Optics, Inc., Alcon Surgical, Inc., and i-Optics  Corp.

title: Comparison of corneal power, XXXX , and wavefront aberration measurements obtained by a point-source color light-emitting diode-based topographer, a  Placido-disk topographer, and a combined Placido and dual Scheimpflug device.

answer: @entity1


abstract: PURPOSE: To evaluate the efficacy and safety of using @entity7 0.1% and @entity8 0.5% artificial tears for @entity6 and tear-film stability in eyes after @entity1 surgery. SETTING: Twenty ophthalmic centers in Italy. DESIGN: Prospective randomized case series. METHODS: This study enrolled @entity0 scheduled for unilateral @entity1 surgery. After surgery, @entity0 received artificial tears and a topical steroid-antibiotic (study group) or topical @entity2 -antibiotic alone (control group) and were assessed postoperatively at 1 and 5 weeks. Outcome measures were @entity4 ( @entity4 ), ocular surface disease index (OSDI), frequency of @entity3 evaluated using a visual analog scale (VAS), and corneal @entity5 staining. RESULTS: The study comprised 282 @entity0 . At 5 weeks, the mean @entity4 was statistically significantly higher in the study group than in the control group (P = .0003). The mean OSDI score statistically significantly improved in both groups from 1 to 5 weeks (P < .0001 for both groups); however, there was no statistically significant difference between the groups at these timepoints. The artificial tears statistically significantly improved VAS-assessed @entity3 in the study group compared with the control group at 5 weeks (P < .001). The mean corneal @entity5 staining was significantly reduced in the study group compared with the control group at 5 weeks (P = .002 versus P = .05, respectively). No treatment-related adverse events were reported. CONCLUSION: @entity7 0.1% and @entity8 0.5% ophthalmic solution was effective and well tolerated in reducing @entity6 and improving the clinical outcome after @entity1 surgery. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Effect of a @entity7 and  @entity8 ophthalmic solution on ocular comfort and tear-film instability after XXXX surgery.

answer: @entity1


abstract: PURPOSE: To evaluate the efficacy and safety of using @entity7 0.1% and @entity8 0.5% artificial tears for @entity6 and tear-film stability in eyes after @entity1 surgery. SETTING: Twenty ophthalmic centers in Italy. DESIGN: Prospective randomized case series. METHODS: This study enrolled @entity0 scheduled for unilateral @entity1 surgery. After surgery, @entity0 received artificial tears and a topical steroid-antibiotic (study group) or topical @entity2 -antibiotic alone (control group) and were assessed postoperatively at 1 and 5 weeks. Outcome measures were @entity4 ( @entity4 ), ocular surface disease index (OSDI), frequency of @entity3 evaluated using a visual analog scale (VAS), and corneal @entity5 staining. RESULTS: The study comprised 282 @entity0 . At 5 weeks, the mean @entity4 was statistically significantly higher in the study group than in the control group (P = .0003). The mean OSDI score statistically significantly improved in both groups from 1 to 5 weeks (P < .0001 for both groups); however, there was no statistically significant difference between the groups at these timepoints. The artificial tears statistically significantly improved VAS-assessed @entity3 in the study group compared with the control group at 5 weeks (P < .001). The mean corneal @entity5 staining was significantly reduced in the study group compared with the control group at 5 weeks (P = .002 versus P = .05, respectively). No treatment-related adverse events were reported. CONCLUSION: @entity7 0.1% and @entity8 0.5% ophthalmic solution was effective and well tolerated in reducing @entity6 and improving the clinical outcome after @entity1 surgery. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Effect of a @entity7 and  XXXX ophthalmic solution on ocular comfort and tear-film instability after @entity1 surgery.

answer: @entity8


abstract: PURPOSE: To evaluate the efficacy and safety of using @entity7 0.1% and @entity8 0.5% artificial tears for @entity6 and tear-film stability in eyes after @entity1 surgery. SETTING: Twenty ophthalmic centers in Italy. DESIGN: Prospective randomized case series. METHODS: This study enrolled @entity0 scheduled for unilateral @entity1 surgery. After surgery, @entity0 received artificial tears and a topical steroid-antibiotic (study group) or topical @entity2 -antibiotic alone (control group) and were assessed postoperatively at 1 and 5 weeks. Outcome measures were @entity4 ( @entity4 ), ocular surface disease index (OSDI), frequency of @entity3 evaluated using a visual analog scale (VAS), and corneal @entity5 staining. RESULTS: The study comprised 282 @entity0 . At 5 weeks, the mean @entity4 was statistically significantly higher in the study group than in the control group (P = .0003). The mean OSDI score statistically significantly improved in both groups from 1 to 5 weeks (P < .0001 for both groups); however, there was no statistically significant difference between the groups at these timepoints. The artificial tears statistically significantly improved VAS-assessed @entity3 in the study group compared with the control group at 5 weeks (P < .001). The mean corneal @entity5 staining was significantly reduced in the study group compared with the control group at 5 weeks (P = .002 versus P = .05, respectively). No treatment-related adverse events were reported. CONCLUSION: @entity7 0.1% and @entity8 0.5% ophthalmic solution was effective and well tolerated in reducing @entity6 and improving the clinical outcome after @entity1 surgery. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Effect of a XXXX and  @entity8 ophthalmic solution on ocular comfort and tear-film instability after @entity1 surgery.

answer: @entity7


abstract: OBJECTIVE: @entity1 ( @entity1 ) has become an alternative to carotid endarterectomy (CEA) for select @entity0 with @entity1 . We hypothesized that the choice of @entity1 vs CEA varies as a function of treating physician specialty, which would result in regional variation in the relative use of these treatment types. METHODS: We used Medicare claims (2002-2010) to calculate annual rates of @entity1 and CEA and examined changes by procedure type over time. To assess regional preferences surrounding @entity1 , we calculated the proportion of revascularizations by @entity1 , across hospital referral regions, defined according to the Dartmouth Atlas of Healthcare. We then examined relationships between @entity0 factors, physician specialty, and regional use of @entity1 . RESULTS: The annual number of all carotid revascularization procedures decreased by 30% from 2002 to 2010 (3.2 to 2.3 per 1000; P = .005). Whereas rates of CEA declined by 35% during these 8 years (3.0 to 1.9 per 1000; P < .001), @entity1 utilization increased by 5% during the same interval (0.30 to 0.32 per 1000; P = .014). Variation in utilization of carotid revascularization varied across the Unites States, with some regions performing as few as 0.7 carotid procedure per 1000 beneficiaries (Honolulu, Hawaii) and others performing nearly 8 times as many (5.3 per 1000 in Houma, La). Variation in procedure type (CEA vs @entity1 ) was evident as well, as the proportion of carotid revascularization procedures that were constituted by @entity1 varied from 0% (Casper, Wyo, and Meridian, Miss) to 53% (Bend, Ore). The majority of @entity1 procedures were performed by cardiologists (49% of all @entity1 cases), who doubled their rates of @entity1 during the study period from 0.07 per 1000 in 2002 to 0.15 per 1000 in 2010. CONCLUSIONS: Variation in rates of carotid revascularization exists. Whereas rates of carotid revascularization have declined by more than 30% in recent years, utilization of @entity1 has increased. The proportion of all carotid revascularization procedures performed as @entity1 varies markedly by geographic region, and regions with the highest proportion of cardiologists perform the most @entity1 procedures. Evidence-based guidelines for carotid revascularization will require a multidisciplinary approach to ensure uniform adoption across specialties that care for @entity0 with @entity1 .

title: Physician specialty and variation in carotid revascularization technique selected for Medicare XXXX .

answer: @entity0


abstract: BACKGROUND: A hallmark of @entity1 is their ability to secrete mucus. Aberrant expression of mucins and alterations in their glycosylation are associated with the development and progression of @entity0 . Therefore, mucins can be used as markers of @entity0 . @entity0 -associated mucins are also used as immunotargets in the treatment of @entity0 . The present work aimed to study the patterns of expression of @entity2 , @entity4 and @entity3 in @entity1 using immunohistochemistry and their relationship with site, histological differentiation and stage. METHODS: Fifty cases of @entity1 were chosen for the study. The histopathology slides were reviewed and blocks were retrieved. Using manual method, tissue microarray blocks were prepared. Immunostaining for @entity2 , @entity4 and @entity3 was performed on slides cut from the tissue microarray block. RESULTS: We found that @entity2 expression was upregulated to 39  %, @entity4 expression was downregulated to 43  % and @entity3 was aberrantly expressed in 24  % of @entity1 ( @entity1 ). There was a significant correlation between @entity2 positivity and @entity0 differentiation. As the grade increased from well to moderately differentiated, @entity2 expression increased from 1   1 % to 55  % (p-value 0.01). There was a statistically significant difference between @entity3 positivity and grade of @entity0 (p-value 0.006). The percentage of cases showing @entity3 expression increased as the stage of disease progressed from 1 to 4. However, there was no significant difference in @entity3 positivity and stage of @entity1 (p-value 0.77). CONCLUSION: We do not find any correlation between @entity0 stage or site and @entity2 , @entity4 or @entity3 expression. @entity2 and @entity3 expression showed significant correlation with @entity0 grade.

title: Immunohistochemical study of XXXX , @entity4 and @entity3 in @entity1 and review of literature.

answer: @entity2


abstract: BACKGROUND: A hallmark of @entity1 is their ability to secrete mucus. Aberrant expression of mucins and alterations in their glycosylation are associated with the development and progression of @entity0 . Therefore, mucins can be used as markers of @entity0 . @entity0 -associated mucins are also used as immunotargets in the treatment of @entity0 . The present work aimed to study the patterns of expression of @entity2 , @entity4 and @entity3 in @entity1 using immunohistochemistry and their relationship with site, histological differentiation and stage. METHODS: Fifty cases of @entity1 were chosen for the study. The histopathology slides were reviewed and blocks were retrieved. Using manual method, tissue microarray blocks were prepared. Immunostaining for @entity2 , @entity4 and @entity3 was performed on slides cut from the tissue microarray block. RESULTS: We found that @entity2 expression was upregulated to 39  %, @entity4 expression was downregulated to 43  % and @entity3 was aberrantly expressed in 24  % of @entity1 ( @entity1 ). There was a significant correlation between @entity2 positivity and @entity0 differentiation. As the grade increased from well to moderately differentiated, @entity2 expression increased from 1   1 % to 55  % (p-value 0.01). There was a statistically significant difference between @entity3 positivity and grade of @entity0 (p-value 0.006). The percentage of cases showing @entity3 expression increased as the stage of disease progressed from 1 to 4. However, there was no significant difference in @entity3 positivity and stage of @entity1 (p-value 0.77). CONCLUSION: We do not find any correlation between @entity0 stage or site and @entity2 , @entity4 or @entity3 expression. @entity2 and @entity3 expression showed significant correlation with @entity0 grade.

title: Immunohistochemical study of @entity2 , @entity4 and @entity3 in XXXX and review of literature.

answer: @entity1


abstract: BACKGROUND: A hallmark of @entity1 is their ability to secrete mucus. Aberrant expression of mucins and alterations in their glycosylation are associated with the development and progression of @entity0 . Therefore, mucins can be used as markers of @entity0 . @entity0 -associated mucins are also used as immunotargets in the treatment of @entity0 . The present work aimed to study the patterns of expression of @entity2 , @entity4 and @entity3 in @entity1 using immunohistochemistry and their relationship with site, histological differentiation and stage. METHODS: Fifty cases of @entity1 were chosen for the study. The histopathology slides were reviewed and blocks were retrieved. Using manual method, tissue microarray blocks were prepared. Immunostaining for @entity2 , @entity4 and @entity3 was performed on slides cut from the tissue microarray block. RESULTS: We found that @entity2 expression was upregulated to 39  %, @entity4 expression was downregulated to 43  % and @entity3 was aberrantly expressed in 24  % of @entity1 ( @entity1 ). There was a significant correlation between @entity2 positivity and @entity0 differentiation. As the grade increased from well to moderately differentiated, @entity2 expression increased from 1   1 % to 55  % (p-value 0.01). There was a statistically significant difference between @entity3 positivity and grade of @entity0 (p-value 0.006). The percentage of cases showing @entity3 expression increased as the stage of disease progressed from 1 to 4. However, there was no significant difference in @entity3 positivity and stage of @entity1 (p-value 0.77). CONCLUSION: We do not find any correlation between @entity0 stage or site and @entity2 , @entity4 or @entity3 expression. @entity2 and @entity3 expression showed significant correlation with @entity0 grade.

title: Immunohistochemical study of @entity2 , XXXX and @entity3 in @entity1 and review of literature.

answer: @entity4


abstract: BACKGROUND: A hallmark of @entity1 is their ability to secrete mucus. Aberrant expression of mucins and alterations in their glycosylation are associated with the development and progression of @entity0 . Therefore, mucins can be used as markers of @entity0 . @entity0 -associated mucins are also used as immunotargets in the treatment of @entity0 . The present work aimed to study the patterns of expression of @entity2 , @entity4 and @entity3 in @entity1 using immunohistochemistry and their relationship with site, histological differentiation and stage. METHODS: Fifty cases of @entity1 were chosen for the study. The histopathology slides were reviewed and blocks were retrieved. Using manual method, tissue microarray blocks were prepared. Immunostaining for @entity2 , @entity4 and @entity3 was performed on slides cut from the tissue microarray block. RESULTS: We found that @entity2 expression was upregulated to 39  %, @entity4 expression was downregulated to 43  % and @entity3 was aberrantly expressed in 24  % of @entity1 ( @entity1 ). There was a significant correlation between @entity2 positivity and @entity0 differentiation. As the grade increased from well to moderately differentiated, @entity2 expression increased from 1   1 % to 55  % (p-value 0.01). There was a statistically significant difference between @entity3 positivity and grade of @entity0 (p-value 0.006). The percentage of cases showing @entity3 expression increased as the stage of disease progressed from 1 to 4. However, there was no significant difference in @entity3 positivity and stage of @entity1 (p-value 0.77). CONCLUSION: We do not find any correlation between @entity0 stage or site and @entity2 , @entity4 or @entity3 expression. @entity2 and @entity3 expression showed significant correlation with @entity0 grade.

title: Immunohistochemical study of @entity2 , @entity4 and XXXX in @entity1 and review of literature.

answer: @entity3


abstract: UNASSIGNED: Action observation is known to trigger predictions of the ongoing course of action and thus considered a hallmark example for predictive perception. A related task, which explicitly taps into the ability to predict actions based on their internal representations, is action segmentation; the task requires @entity0 to demarcate where one action step is completed and another one begins. It thus benefits from a temporally precise prediction of the current action. Formation and exploitation of these temporal predictions of external events is now closely associated with a network including the basal ganglia and prefrontal cortex. Because decline of dopaminergic innervation leads to impaired function of the basal ganglia and prefrontal cortex in @entity1 ( @entity1 ), we hypothesised that @entity1 @entity0 would show increased temporal variability in the action segmentation task, especially under medication withdrawal (hypothesis 1). Another crucial aspect of action segmentation is its reliance on a semantic representation of actions. There is no evidence to suggest that action representations are substantially altered, or cannot be accessed, in non-demented @entity1 @entity0 . We therefore expected action segmentation judgments to follow the same overall patterns in @entity1 @entity0 and healthy controls (hypothesis 2), resulting in comparable segmentation profiles. Both hypotheses were tested with a novel classification approach. We present evidence for both hypotheses in the present study: classifier performance was slightly decreased when it was tested for its ability to predict the identity of movies segmented by @entity1 @entity0 , and a measure of normativity of response behaviour was decreased when @entity0 segmented movies under medication-withdrawal without access to an episodic memory of the sequence. This pattern of results is consistent with hypothesis 1. However, the classifier analysis also revealed that responses given by @entity0 and controls create very similar action-specific patterns, thus delivering evidence in favour hypothesis 2. In terms of methodology, the use of classifiers in the present study allowed us to establish similarity of behaviour across groups (hypothesis 2). The approach opens up a new avenue that standard statistical methods often fail to provide and is discussed in terms of its merits to measure hypothesised similarities across study populations.

title: Intact action segmentation in XXXX : Hypothesis testing using a novel computational approach.

answer: @entity1


abstract: PURPOSE: To retrospectively evaluate radiofrequency (RF) ablation of @entity1 performed via the transosseous approach. MATERIALS AND METHODS: Twelve @entity1 (mean diameter, 1.0 cm; range, 0.4-1.6 cm) in 12 @entity0 were treated by RF ablation via a transscapular and/or transrib route with the use of a bone biopsy needle under computed tomographic fluoroscopy guidance. Therapeutic outcomes evaluated included feasibility, safety, and local efficacy. Complications were assessed based on the National @entity2 Institute Common Terminology Criteria for Adverse Events, version 4.0. RESULTS: The transosseous route was successfully employed in all @entity0 , and the electrode was successfully advanced into all @entity2 with this approach. The mean distance of penetrated bone was 0.57 cm (range, 0.19-1.16 cm). Complications occurred in eight RF ablation sessions, including six grade 1 events (two cases of pneumothorax and one case each of asymptomatic @entity5 6 mo after treatment, @entity3 , @entity6 , and hemothorax), two grade 2 events ( @entity4 and high fever), and one grade 3 event (pneumothorax requiring pleurodesis). No adverse events of grade >=  4 occurred. The mean and median @entity2 follow-up periods were 19.5 and 15.2 mo (range, 3.0-41.5 mo). Local progression occurred in two cases at 3 and 12 mo after treatment and was successfully treated with a second RF ablation procedure. The technique efficacy rates were 91.7% at 6 mo, 81.5% at 1 y, and 81.5% at 2 y. CONCLUSIONS: The transosseous approach was feasible in computed tomographic fluoroscopy-guided RF ablation of select @entity1 when no other option was available.

title: Transosseous Route for CT Fluoroscopy-Guided Radiofrequency Ablation of XXXX .

answer: @entity1


abstract: UNASSIGNED: Background. The definition of ultra-high risk (UHR) for @entity5 was derived from community-based help-seeking populations. Prisoners have high rates of @entity5 and other severe @entity6 ( @entity6 ) problems. They also have high rates of risk factors for @entity1 morbidity and yet they are among the populations who are less likely to seek help in the community. Despite a policy of equivalence of care for individuals in prison there are no early intervention services for @entity5 in prisons in the UK. This was a study exploring feasibility of introducing such a service into a local London prison. This paper discusses the differences in @entity6 profile of prisoners who met criteria for at-risk mental state compared with those who did not. Method. A two-stage procedure was used. @entity0 in a local London prison were routinely screened in the first week of arrival in prison with the Prodrome Questionnaire - Brief Version (PQ-B; Loewy et al. 2011). Those that screened positive as well as a small sample of those who screened negative underwent a further semi-structured assessment to see whether they met criteria for UHR state. Data on self-harm and suicide attempt, family @entity1 history, and @entity2 and @entity4 was also collected. Results. A total of 891 prisoners were screened, 44% of whom screened positive. A total of 354 underwent second stage assessment, 60 of whom had screened negative. Four groups were identified: those that had no @entity6 problems, a group experiencing First Episode Psychosis, those at UHR of @entity5 and a group with other @entity6 problems. The UHR state and Psychotic groups had very similar @entity6 profiles of symptoms and distress. Prisoners with no @entity6 problems were at the other end of the spectrum with few symptoms and @entity3 . The Other group fell in between this group and the @entity5 spectrum group in terms of symptomology and distress. Conclusions. This study is the first to examine risk for @entity5 in an adult male prison population. We identified a broad spectrum of @entity1 for which there is little current service provision in prisons. Screening early in the custodial process has the potential to identify unmet @entity6 need and has implications for keeping individuals safe in custody. A long-term strategic approach is required to address @entity6 need in prisons.

title: Prisoners at ultra-high-risk for XXXX : a cross-sectional study.

answer: @entity5


abstract: PURPOSE: The purpose of the study was to determine whether intensity modulated radiation therapy delivered via helical tomotherapy improves local control (LC) after pleurectomy/decortication (P/D) for @entity3 compared with 3-dimensional conformal radiation therapy (3D-CRT). METHODS AND MATERIALS: Forty-five consecutive @entity0 were treated with adjuvant radiation to 45 Gy in 1.8 Gy fractions after P/D between 2006 and 2014; 23 received 3D-CRT, and 22 received tomotherapy. Kaplan-Meier analysis was used to calculate overall survival, time to in-field or local failure (LF), and time to out-of-field failure. The Student t test and Fisher exact test were used to detect between-group differences. RESULTS: Median follow-up time was 19.4 months and 12.7 months for the 3D-CRT and tomotherapy groups, respectively. Eighty-two percent of @entity0 had T3/T4 disease, and 64% had positive nodes; 17.4% and 41% of @entity0 in the 3D-CRT and tomotherapy groups had nonepithelioid histology, respectively. Mean planning target volume dose, percentage of planning target volume receiving 100% of the prescription dose, and lung doses were significantly greater with tomotherapy (P < .05), but @entity2 rates (including radiation @entity1 rates) were equivalent. LC was significantly improved with tomotherapy on Kaplan-Meier analysis with outcomes censored at 2 years (P < .05); uncensored, this became a trend (P = .06). Median time to LF was 19 months with tomotherapy and 10.9 months in 3D-CRT (the latter interval being less than the median follow-up in the tomotherapy group). On univariate analysis, treatment modality was the only significant predictor of LC (P < .05). Isolated LF was significantly more frequent with 3D-CRT (P < .05). Conversely, isolated out-of-field failure was significantly more frequent with tomotherapy (P < .05). Overall survival and out-of-field control were not significantly different. CONCLUSION: Tomotherapy after P/D for @entity3 is associated with improved target coverage that translates into improved LC compared with 3D-CRT. This is related to a change in failure patterns, with isolated LF being more common in the 3D-CRT group and isolated out-of-field failures predominating in the tomotherapy group.

title: Tomotherapy improves local control and changes failure patterns in locally advanced XXXX .

answer: @entity3


abstract: OBJECTIVE: To explore the diagnostic value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) combined with Surepath liquid-based cytology test for lung and mediastinal @entity5 . METHODS: Eighty EBUS-TBNA cases in West China Hospital of Sichuan University collected from December 2011 to June 2014 were retrospectively analyzed. The conventional smears and Surepath liquid based preparations were reviewed and compared with histological biopsy. Evaluated whether liquid based preparation could improve the satisfactory rate and diagnostic accuracy. RESULTS: This study included 53 @entity0 and 27 @entity0 , the male to female ratio was 1.96:1.00; the age ranged from 17 to 79 (mean 54) years. One to four lymph node groups were aspirated in each @entity0 , resulting in a total of 109 lymph node groups, including 57 paratracheal, 34 subcarinal, three tracheal bronchial, seven pulmonary and four hilar lymph node groups. The definite locations of four other mediastinal lymph node groups were not known. The overall satisfactory rate of conventional smears and liquid-based cytology test was 90.0% and 92.5%, respectively. By histology, there were 37 cases diagnosed as @entity1 , nine as @entity4 , two as @entity3 , 11 as unexplained @entity2 , and 27 as other benign lesions. The sensitivity, specificity and accuracy of conventional cytological smears for @entity1 were 86.5%, 97.7% and 92.5% respectively; the positive and negative predictive values were 97.0% and 89.4% respectively. The sensitivity, specificity and accuracy of the liquid-based preparation were 89.2%, 97.7% and 93.8% respectively; the positive and negative predictive values were 97.1% and 91.3% respectively. Combining the conventional cytological smears and liquid based preparation, the sensitivity, specificity and accuracy were 91.9%, 97.7% and 95.0% respectively; and the positive and negative predictive values were 97.1% and 93.3% respectively. CONCLUSIONS: EBUS-TBNA is a good method to diagnose lung and mediastinal @entity5 . Surepath liquid based cytology test could improve the sample satisfactory rate, the diagnostic sensitivity and accuracy. If combined with immunocytochemistry it could be useful for further @entity1 typing. EBUS-TBNA combined with Surepath liquid based preparation is an effective complement for the histologic biopsy.

title: [Diagnostic value of endobronchial ultrasound-guided transbronchial needle aspiration combined with Surepath liquid-based cytology test for lung lesions and mediastinal XXXX ].

answer: @entity5


abstract: OBJECTIVES: Growth and progress of @entity3 ( @entity3 ) severely disrupt the blood brain barrier (BBB). Such disruptions can be intraoperatively visualized by injecting @entity4 ( @entity6 ) and applying a YELLOW 560nm surgical microscope filter. Here, we report a small cohort of @entity0 with @entity3 that mimicked high grade @entity2 (HGG) or @entity5 ( @entity5 ), who had been operated on with the use of @entity6 . @entity0 AND METHODS: Retrospectively, seven @entity0 with @entity3 were identified, who had been operated on by means of microsurgery after intravenous @entity6 injection. The surgical reports were screened for statements on the grade of fluorescent staining in the @entity1 area. One representative case was chosen to show the staining under white light as well as under filtered light at different distances to the @entity1 area. RESULTS: All @entity0 had shown bright and homogenous fluorescent staining of the @entity1 (n=7. 100%). No adverse effects had been observed. CONCLUSION: Similar to @entity0 with HGG or @entity5 , @entity0 with @entity3 may benefit from use of @entity6 and the dedicated YELLOW 560nm filter in open surgery.

title: @entity4 -guided surgery in XXXX .

answer: @entity3


abstract: OBJECTIVES: Growth and progress of @entity3 ( @entity3 ) severely disrupt the blood brain barrier (BBB). Such disruptions can be intraoperatively visualized by injecting @entity4 ( @entity6 ) and applying a YELLOW 560nm surgical microscope filter. Here, we report a small cohort of @entity0 with @entity3 that mimicked high grade @entity2 (HGG) or @entity5 ( @entity5 ), who had been operated on with the use of @entity6 . @entity0 AND METHODS: Retrospectively, seven @entity0 with @entity3 were identified, who had been operated on by means of microsurgery after intravenous @entity6 injection. The surgical reports were screened for statements on the grade of fluorescent staining in the @entity1 area. One representative case was chosen to show the staining under white light as well as under filtered light at different distances to the @entity1 area. RESULTS: All @entity0 had shown bright and homogenous fluorescent staining of the @entity1 (n=7. 100%). No adverse effects had been observed. CONCLUSION: Similar to @entity0 with HGG or @entity5 , @entity0 with @entity3 may benefit from use of @entity6 and the dedicated YELLOW 560nm filter in open surgery.

title: XXXX -guided surgery in @entity3 .

answer: @entity4