abstract: One hundred and sixty-one @entity0 who were treated with @entity4 mustard, @entity5 , @entity7 , and @entity2 (MOPP) chemotherapy for @entity3 have been observed for a median of 10.2 years. Eighty-two percent of those @entity0 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity0 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity1 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity0 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity0 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity0 who had died at the time of the analysis of this series, 46 died of progressive @entity3 . All four @entity0 who developed secondary @entity6 had received radiation as well as MOPP.

title: @entity4 mustard, @entity5 , @entity7 , and @entity2 for relapse after radiation in XXXX . An analysis of long-term follow-up.

answer: @entity3


abstract: One hundred and sixty-one @entity0 who were treated with @entity4 mustard, @entity5 , @entity7 , and @entity2 (MOPP) chemotherapy for @entity3 have been observed for a median of 10.2 years. Eighty-two percent of those @entity0 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity0 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity1 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity0 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity0 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity0 who had died at the time of the analysis of this series, 46 died of progressive @entity3 . All four @entity0 who developed secondary @entity6 had received radiation as well as MOPP.

title: @entity4 mustard, @entity5 , XXXX , and @entity2 for relapse after radiation in @entity3 . An analysis of long-term follow-up.

answer: @entity7


abstract: One hundred and sixty-one @entity0 who were treated with @entity4 mustard, @entity5 , @entity7 , and @entity2 (MOPP) chemotherapy for @entity3 have been observed for a median of 10.2 years. Eighty-two percent of those @entity0 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity0 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity1 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity0 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity0 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity0 who had died at the time of the analysis of this series, 46 died of progressive @entity3 . All four @entity0 who developed secondary @entity6 had received radiation as well as MOPP.

title: @entity4 mustard, @entity5 , @entity7 , and XXXX for relapse after radiation in @entity3 . An analysis of long-term follow-up.

answer: @entity2


abstract: With single-beat analysis, the new concept of systolic @entity3 is applied to provide a new approach for the assessment of myocardial contractility in aortic and @entity5 . Seventy @entity0 underwent diagnostic right and left heart catheterization. Twenty-six @entity0 had @entity6 , 18 had @entity4 , and 26 had @entity5 . @entity0 with @entity6 were divided into two groups on the basis of left ventricular mass index less than 172 g/m2 ( @entity8 ) and mass index greater than or equal to 172 g/m2 (AS2). The @entity5 @entity0 were divided into those in normal sinus rhythm ( @entity9 ) and those in @entity7 (MR2). Nine @entity0 without significant @entity1 served as controls. Thirteen @entity0 with @entity6 and eight with @entity4 were evaluated (average, approximately 18 months) after successful aortic valve replacement. With simultaneous left ventricular pressure and cineangiographic methods, myocardial contractility was assessed by the conventional ejection fraction-afterload relation (uncorrected for preload) and by two new methods that permit the correction of the ejection fraction for preload. Assessments of the contractile state by these two new methods differed from those by the conventional method in 20-40% of the cases studied. Contractile state improved postoperatively in @entity6 and @entity4 even in @entity0 with preoperative depressed contractile states. In @entity0 with @entity5 , there was considerable heterogeneity of contractile function preoperatively. Severe left @entity2 in @entity6 was not a marker for postoperative outcome since contractility was normal postoperatively in @entity8 and AS2 in equal numbers. This study demonstrates that preload correction is important in a preoperative assessment of contractility in aortic and @entity5 but that it is less important postoperatively, presumably because of reductions in the preload.

title: Correction for preload in assessment of myocardial contractility in aortic and @entity5 . Application of the concept of systolic XXXX .

answer: @entity3


abstract: With single-beat analysis, the new concept of systolic @entity3 is applied to provide a new approach for the assessment of myocardial contractility in aortic and @entity5 . Seventy @entity0 underwent diagnostic right and left heart catheterization. Twenty-six @entity0 had @entity6 , 18 had @entity4 , and 26 had @entity5 . @entity0 with @entity6 were divided into two groups on the basis of left ventricular mass index less than 172 g/m2 ( @entity8 ) and mass index greater than or equal to 172 g/m2 (AS2). The @entity5 @entity0 were divided into those in normal sinus rhythm ( @entity9 ) and those in @entity7 (MR2). Nine @entity0 without significant @entity1 served as controls. Thirteen @entity0 with @entity6 and eight with @entity4 were evaluated (average, approximately 18 months) after successful aortic valve replacement. With simultaneous left ventricular pressure and cineangiographic methods, myocardial contractility was assessed by the conventional ejection fraction-afterload relation (uncorrected for preload) and by two new methods that permit the correction of the ejection fraction for preload. Assessments of the contractile state by these two new methods differed from those by the conventional method in 20-40% of the cases studied. Contractile state improved postoperatively in @entity6 and @entity4 even in @entity0 with preoperative depressed contractile states. In @entity0 with @entity5 , there was considerable heterogeneity of contractile function preoperatively. Severe left @entity2 in @entity6 was not a marker for postoperative outcome since contractility was normal postoperatively in @entity8 and AS2 in equal numbers. This study demonstrates that preload correction is important in a preoperative assessment of contractility in aortic and @entity5 but that it is less important postoperatively, presumably because of reductions in the preload.

title: Correction for preload in assessment of myocardial contractility in aortic and XXXX . Application of the concept of systolic @entity3 .

answer: @entity5


abstract: We studied 19 young @entity0 (aged 15 to 39 months) who had had a @entity1 after imported fire ant (IFA) sting. Skin testing was performed with whole body extract (WBE) of both @entity4 species; positive reactions to @entity3 was noted in 94% and to @entity4 in 100%. Serum was tested for total IgE level and for specific IgE antibodies by RAST with WBE and venom (V) of @entity3 . In vitro results were compared with those of 19 age and sex-matched atopic control subjects. The range of total serum IgE level was 31 to 1720 IU/ml (geometric mean 160 IU/ml), compared with 7.5 to 6756 IU/ml (geometric mean 85 IU/ml) in the control subjects. The difference between the two groups, however, was not statistically significant (p greater than 0.05). In the IFA- @entity1 group, the IFA WBE RAST mean binding was 13.5% (range 2.0% to 30.2%), and the IFA V RAST mean was 29.2% (range 7.8% to 46.7%). The control sera demonstrated low levels of activity to both IFA WBE RAST (0.7% to 4.8%) and IFA V RAST (0.7% to 5.9%). IFA WBE RAST demonstrated that 26% of the IFA- @entity1 @entity0 had counts within the range of the atopic control subjects. In contrast, the IFA V RAST clearly separated all IFA- @entity1 @entity0 from their age and sex-matched atopic control subjects. A scoring system for IFA V RAST is proposed. These results demonstrate superiority of IFA V over IFA WBE RAST in the diagnosis of @entity2 to @entity3 .

title: Imported fire ant XXXX in young @entity0 : skin reactivity and serum IgE antibodies to venom and whole body extract.

answer: @entity2


abstract: We studied 19 young @entity0 (aged 15 to 39 months) who had had a @entity1 after imported fire ant (IFA) sting. Skin testing was performed with whole body extract (WBE) of both @entity4 species; positive reactions to @entity3 was noted in 94% and to @entity4 in 100%. Serum was tested for total IgE level and for specific IgE antibodies by RAST with WBE and venom (V) of @entity3 . In vitro results were compared with those of 19 age and sex-matched atopic control subjects. The range of total serum IgE level was 31 to 1720 IU/ml (geometric mean 160 IU/ml), compared with 7.5 to 6756 IU/ml (geometric mean 85 IU/ml) in the control subjects. The difference between the two groups, however, was not statistically significant (p greater than 0.05). In the IFA- @entity1 group, the IFA WBE RAST mean binding was 13.5% (range 2.0% to 30.2%), and the IFA V RAST mean was 29.2% (range 7.8% to 46.7%). The control sera demonstrated low levels of activity to both IFA WBE RAST (0.7% to 4.8%) and IFA V RAST (0.7% to 5.9%). IFA WBE RAST demonstrated that 26% of the IFA- @entity1 @entity0 had counts within the range of the atopic control subjects. In contrast, the IFA V RAST clearly separated all IFA- @entity1 @entity0 from their age and sex-matched atopic control subjects. A scoring system for IFA V RAST is proposed. These results demonstrate superiority of IFA V over IFA WBE RAST in the diagnosis of @entity2 to @entity3 .

title: Imported fire ant @entity2 in young XXXX : skin reactivity and serum IgE antibodies to venom and whole body extract.

answer: @entity0


abstract: A new periacetabular osteotomy of the pelvis has been used for the treatment of residual @entity2 in adolescents and adults. The identification of the joint capsule is performed through a Smith-Petersen approach, which also permits all osteotomies to be performed about the acetabulum. This osteotomy does not change the diameter of the true pelvis, but allows an extensive acetabular reorientation including medial and lateral displacement. Preparations and injections of the vessels of the hip joint on cadavers have shown that the osteotomized fragment perfusion after correction is sufficient. Because the posterior pillar stays mechanically intact the acetabular fragment can be stabilized sufficiently using two screws. This stability allows @entity0 to partially bear weight after osteotomy without immobilization. Since 1984, 75 periacetabular osteotomies of the hip have been performed. The corrections are 31 degrees for the vertical center-edge (VCE) angle of Wiberg and 26 degrees for the corresponding angle of Lequesne and de Seze in the sagittal plane. Complications have included two @entity5 , a @entity3 that resolved, one nonunion, and ectopic bone formation in four @entity0 prior to the prophylactic use of @entity4 . Thirteen @entity0 required screw removal. There was no evidence of @entity1 of the osteotomized fragment.

title: A new periacetabular osteotomy for the treatment of XXXX . Technique and preliminary results.

answer: @entity2


abstract: Falls are a leading cause of fatal and nonfatal injuries among the elderly in the United States. Despite the importance of @entity1 , epidemiological studies of falls among the elderly have identified neither their causes nor the methods to prevent them. Therefore, we established a community-based surveillance system in Miami Beach, Florida, as part of a study to assess falls among the elderly. A total of 1,827 @entity1 events occurred in this community between July 1985 and June 1986. More than 85% (1,567) of the @entity0 who fell and received care were seen in an emergency room. The remaining cases were identified from one of the three other sources used: fire rescue reports, inpatient medical records, or medical examiner reports. Most falls (97%) were coded as accidental (E880-E888). More than 100 @entity0 sought medical assistance for a fall each month. The time of the injury was known for 68% (1,244) of the @entity0 who fell. Seventy-four percent of these falls (921) occurred during daylight hours. Fifty-four percent of the falls (986) occurred in and around the home, and 38% of these had a particular area of the home recorded: 42% occurred in the bedroom, 34% in the bathroom, 9% in the kitchen, 5% on the stairs, 4% in the living room, and the remaining 6% in other areas. This surveillance system will help us use the study to clarify the causes of falls in the elderly and identify and evaluate appropriate prevention efforts. It will also help others in designing and implementing other @entity2 .

title: XXXX among the elderly. Community-based surveillance.

answer: @entity1


abstract: @entity1 ( @entity1 ) prepared from bone marrow (BM) or spleen (SPL) cells from @entity0 injected with @entity2 in doses ranging from 0.0001 to 10 micrograms was found to contain an activity inhibitory to the proliferation of granulocyte-monocyte progenitor cells (CFU-GM). This activity was found in medium conditioned for 24 to 48 h, but was not present in medium conditioned for longer time intervals. BM cells from @entity2 -treated @entity0 incubated over a concentration range of 0.1 to 1.0 x 10(6) cells/ml and SPL cells over a range of 1.0 to 10 x 10(6) cells/ml produced @entity1 with equivalent degrees of inhibition for CFU-GM proliferation. Titration of this activity revealed a significant inhibitory effect still present at a 1/256 dilution. Inhibitory activity was similar whether or not @entity1 was prepared in the presence or absence of FCS. Inhibition of CFU-GM development was approximately equal in the presence of either PWM SPL @entity1 or L cell @entity1 as sources of CSF activity. Morphologic analysis of CFU-GM revealed an equivalent inhibition of monocyte, monocyte-neutrophil, and neutrophil CFU-GM by the @entity2 -stimulated inhibitory activity. Equivalent picogram amounts of @entity4 were measured in @entity1 derived from BM or SPL cells from either control or @entity2 -treated @entity0 , indicating a low probability that injected @entity2 was carried over in the @entity1 and contributed to CFU-GM inhibition. Protease digestion of BM or SPL cell @entity1 from @entity2 -treated @entity0 revealed a loss of inhibitory activity after trypsin, chymotrypsin, pronase, and neuraminidase treatment. Inhibitory activity was also ablated by heat treatment at 56 degrees C for 30 min and 100 degrees C for 5 min. @entity3 -agarose gel filtration of BM @entity1 revealed an active inhibitory fraction in the Mr range of 5.5 to 8.0 kDa. The results of the present study suggest that one of the mechanisms by which @entity2 exerts its in vivo myelopoietic inhibitory action may be by stimulating the production of an inhibitory factor or factors from BM and SPL cells.

title: In vivo modulation of myelopoiesis by XXXX . IV. @entity2 induction of myelopoietic inhibitory activity.

answer: @entity2


abstract: @entity1 ( @entity1 ) prepared from bone marrow (BM) or spleen (SPL) cells from @entity0 injected with @entity2 in doses ranging from 0.0001 to 10 micrograms was found to contain an activity inhibitory to the proliferation of granulocyte-monocyte progenitor cells (CFU-GM). This activity was found in medium conditioned for 24 to 48 h, but was not present in medium conditioned for longer time intervals. BM cells from @entity2 -treated @entity0 incubated over a concentration range of 0.1 to 1.0 x 10(6) cells/ml and SPL cells over a range of 1.0 to 10 x 10(6) cells/ml produced @entity1 with equivalent degrees of inhibition for CFU-GM proliferation. Titration of this activity revealed a significant inhibitory effect still present at a 1/256 dilution. Inhibitory activity was similar whether or not @entity1 was prepared in the presence or absence of FCS. Inhibition of CFU-GM development was approximately equal in the presence of either PWM SPL @entity1 or L cell @entity1 as sources of CSF activity. Morphologic analysis of CFU-GM revealed an equivalent inhibition of monocyte, monocyte-neutrophil, and neutrophil CFU-GM by the @entity2 -stimulated inhibitory activity. Equivalent picogram amounts of @entity4 were measured in @entity1 derived from BM or SPL cells from either control or @entity2 -treated @entity0 , indicating a low probability that injected @entity2 was carried over in the @entity1 and contributed to CFU-GM inhibition. Protease digestion of BM or SPL cell @entity1 from @entity2 -treated @entity0 revealed a loss of inhibitory activity after trypsin, chymotrypsin, pronase, and neuraminidase treatment. Inhibitory activity was also ablated by heat treatment at 56 degrees C for 30 min and 100 degrees C for 5 min. @entity3 -agarose gel filtration of BM @entity1 revealed an active inhibitory fraction in the Mr range of 5.5 to 8.0 kDa. The results of the present study suggest that one of the mechanisms by which @entity2 exerts its in vivo myelopoietic inhibitory action may be by stimulating the production of an inhibitory factor or factors from BM and SPL cells.

title: In vivo modulation of myelopoiesis by @entity2 . IV. XXXX induction of myelopoietic inhibitory activity.

answer: @entity2


abstract: We have investigated whether cholera toxin (CT)- or pertussis toxin (IAP)-sensitive G proteins are involved in ovine (o) PRL-stimulated mitogenesis in the lactogen-dependent @entity0 @entity7 @entity2 cell line. Addition of IAP to medium caused a biphasic effect on @entity6 -stimulated cell number. Low doses (10(-3) ng/ml) enhanced (mean +/- SEM, 15 +/- 3%) whereas higher doses (greater than or equal to 10 ng/ml) inhibited (24 +/- 3%) mitogenesis stimulated by a submaximal dose of @entity6 (0.1 ng/ml) compared to control values. The @entity1 analog @entity5 also had a biphasic effect on cell division stimulated by submaximal doses of PRL. Low doses (10(-5) M) enhanced whereas higher doses (10(-3) M) inhibited @entity7 cell growth in response to PRL. Incubation with CT only inhibited @entity6 -stimulated mitogenesis in a dose-dependent manner. Maximal inhibition (63 +/- 7%) occurred at a concentration of 10 ng/ml or more. @entity3 ( @entity4 ) enhanced mitogenesis stimulated by PRL alone and in the presence of either stimulatory or inhibitory doses of IAP, but @entity4 did not block IAP inhibition. In contrast, @entity4 had no effect on cells incubated with CT; the inhibition of PRL-stimulated cell division by CT remained unchanged. Lactogenic receptor-binding sites per cell and affinity were not significantly affected by @entity4 , IAP, or CT, suggesting a postreceptor mechanism of action. In summary, these data demonstrate that @entity1 modifies PRL-stimulated @entity7 cell mitogenesis. The differences between IAP and CT (i.e. biphasic effect, degree of inhibition, and differential effect of @entity4 ) suggest that these agents could also modulate PRL actions in the @entity7 cell through different mechanisms, including a @entity1 -independent pathway.

title: Modulation of prolactin-stimulated @entity7 XXXX cell mitogenesis by cholera toxin and pertussis toxin.

answer: @entity2


abstract: We have investigated whether cholera toxin (CT)- or pertussis toxin (IAP)-sensitive G proteins are involved in ovine (o) PRL-stimulated mitogenesis in the lactogen-dependent @entity0 @entity7 @entity2 cell line. Addition of IAP to medium caused a biphasic effect on @entity6 -stimulated cell number. Low doses (10(-3) ng/ml) enhanced (mean +/- SEM, 15 +/- 3%) whereas higher doses (greater than or equal to 10 ng/ml) inhibited (24 +/- 3%) mitogenesis stimulated by a submaximal dose of @entity6 (0.1 ng/ml) compared to control values. The @entity1 analog @entity5 also had a biphasic effect on cell division stimulated by submaximal doses of PRL. Low doses (10(-5) M) enhanced whereas higher doses (10(-3) M) inhibited @entity7 cell growth in response to PRL. Incubation with CT only inhibited @entity6 -stimulated mitogenesis in a dose-dependent manner. Maximal inhibition (63 +/- 7%) occurred at a concentration of 10 ng/ml or more. @entity3 ( @entity4 ) enhanced mitogenesis stimulated by PRL alone and in the presence of either stimulatory or inhibitory doses of IAP, but @entity4 did not block IAP inhibition. In contrast, @entity4 had no effect on cells incubated with CT; the inhibition of PRL-stimulated cell division by CT remained unchanged. Lactogenic receptor-binding sites per cell and affinity were not significantly affected by @entity4 , IAP, or CT, suggesting a postreceptor mechanism of action. In summary, these data demonstrate that @entity1 modifies PRL-stimulated @entity7 cell mitogenesis. The differences between IAP and CT (i.e. biphasic effect, degree of inhibition, and differential effect of @entity4 ) suggest that these agents could also modulate PRL actions in the @entity7 cell through different mechanisms, including a @entity1 -independent pathway.

title: Modulation of prolactin-stimulated XXXX @entity2 cell mitogenesis by cholera toxin and pertussis toxin.

answer: @entity7


abstract: This study was undertaken to determine the effect of @entity1 and @entity2 on the synthesis of oviduct-specific proteins and to determine if there were changes in the synthesis of these proteins in different regions of the oviduct. Ovariectomized females were either untreated, treated with @entity1 for 7 or 14 days, or primed with @entity1 for 14 days and then treated with @entity1 plus @entity2 or @entity2 alone for either 7 or 14 days. Oviducts were incubated in the presence of labeled @entity3 or @entity7 for 24 h at 37 C, and the culture medium was then analyzed by one- and two-dimensional (2-D) @entity5 gel electrophoresis, followed by fluorography. A family of macromolecules [mol wt (Mr), 100,000-130,000] was only present in the animals treated with @entity1 for 7 or 14 days. 2-D analysis demonstrated that two proteins, one basic and one acidic, were the major @entity1 -responsive proteins in the 100,000-130,000 Mr region. In addition, an acidic protein in this region increased in intensity with @entity1 treatment. All three proteins incorporated @entity3 and @entity7 . Since a steroid-responsive gradient is known to exist in the oviduct, oviducts were divided into fimbria, ampulla, and isthmic regions and cultured separately. 2-D analysis of the medium indicated that the ampulla synthesized both the @entity4 , whereas the acidic protein was dominant in the fimbria and the basic protein was dominant in the isthmus. Another acidic protein (Mr, 110,000) was only present in the fimbria and ampulla. This study clearly demonstrates that the @entity1 -treated @entity6 oviduct synthesizes several proteins that were not detectable in the ovariectomized or @entity2 -treated animal. Also, the different regions of the oviduct have different synthetic capabilities for these proteins. The electrophoretic characteristics of these proteins are similar to those we have observed at midcycle in the intact @entity6 and @entity0 oviduct.

title: The in vitro synthesis of estrogen-dependent proteins by the XXXX ( @entity6 ) oviduct.

answer: @entity6


abstract: This study was undertaken to determine the effect of @entity1 and @entity2 on the synthesis of oviduct-specific proteins and to determine if there were changes in the synthesis of these proteins in different regions of the oviduct. Ovariectomized females were either untreated, treated with @entity1 for 7 or 14 days, or primed with @entity1 for 14 days and then treated with @entity1 plus @entity2 or @entity2 alone for either 7 or 14 days. Oviducts were incubated in the presence of labeled @entity3 or @entity7 for 24 h at 37 C, and the culture medium was then analyzed by one- and two-dimensional (2-D) @entity5 gel electrophoresis, followed by fluorography. A family of macromolecules [mol wt (Mr), 100,000-130,000] was only present in the animals treated with @entity1 for 7 or 14 days. 2-D analysis demonstrated that two proteins, one basic and one acidic, were the major @entity1 -responsive proteins in the 100,000-130,000 Mr region. In addition, an acidic protein in this region increased in intensity with @entity1 treatment. All three proteins incorporated @entity3 and @entity7 . Since a steroid-responsive gradient is known to exist in the oviduct, oviducts were divided into fimbria, ampulla, and isthmic regions and cultured separately. 2-D analysis of the medium indicated that the ampulla synthesized both the @entity4 , whereas the acidic protein was dominant in the fimbria and the basic protein was dominant in the isthmus. Another acidic protein (Mr, 110,000) was only present in the fimbria and ampulla. This study clearly demonstrates that the @entity1 -treated @entity6 oviduct synthesizes several proteins that were not detectable in the ovariectomized or @entity2 -treated animal. Also, the different regions of the oviduct have different synthetic capabilities for these proteins. The electrophoretic characteristics of these proteins are similar to those we have observed at midcycle in the intact @entity6 and @entity0 oviduct.

title: The in vitro synthesis of estrogen-dependent proteins by the @entity6 ( XXXX ) oviduct.

answer: @entity6


abstract: The results of 81 endorectal flap advancements for simple @entity5 are reported. @entity3 are defined as less than 2.5 cm in diameter, low or mid @entity4 in location, and infectious or traumatic in origin. Essentially, the technique is advancement of a flap of mucosa, submucosa, and circular muscle over midline approximation of internal sphincter muscle. The mean @entity0 age was 34 years old (range, 18 to 76 years). The causes were @entity1 (74 percent), @entity2 (10 percent), operative @entity1 (7 percent), and unknown (8 percent). Overall, the repair was successful in 83 percent of @entity0 . Success correlated with the number of previous repairs, i.e., none: 88 percent success; one: 85 percent success; two: 55 percent success. There were 25 concomitant overlapping sphincteroplasty procedures. Only minor complications ensued, with no mortality. This repair is recommended for @entity0 with no or one previous repair because of its lack of mortality, minimal morbidity, ease of concomitant sphincteroplasty, and avoidance of a colostomy. For @entity0 with two or more earlier repairs, a muscle interposition should be considered.

title: Repair of simple XXXX . Influence of previous repairs.

answer: @entity5


abstract: The authors report the case of a 2-year-old @entity0 who presented with @entity10 and short changes characterized by acute drowsiness, cold sweats, ocular reversion, @entity5 , and @entity6 . Between these attacks, the condition was normal, suggesting @entity8 @entity3 . Over 2 months five fits were observed by the parents when some to-and-fro bobbing of the head onto the trunk appeared during drowsiness. One electroencephalogram was normal without a slow background or spikes discharges. As the skull radiographs showed erosion of the jugum and chronic @entity4 features, a CT scan was performed and showed @entity7 associated with a @entity9 . The cyst was opened into basal cisterns with cystoperitoneal shunt. The histological examination revealed that it was an @entity1 . Six months later, the @entity0 was free of @entity8 @entity3 and head bobbing. Thus, we can assert that there was a direct relationship between this cyst and the @entity8 @entity3 . From this case, the authors make a review of the clinical features of @entity2 , and their different causes and show that both @entity2 and suprasellar @entity1 are not common.

title: @entity2 with XXXX in an @entity0 .

answer: @entity9


abstract: The authors report the case of a 2-year-old @entity0 who presented with @entity10 and short changes characterized by acute drowsiness, cold sweats, ocular reversion, @entity5 , and @entity6 . Between these attacks, the condition was normal, suggesting @entity8 @entity3 . Over 2 months five fits were observed by the parents when some to-and-fro bobbing of the head onto the trunk appeared during drowsiness. One electroencephalogram was normal without a slow background or spikes discharges. As the skull radiographs showed erosion of the jugum and chronic @entity4 features, a CT scan was performed and showed @entity7 associated with a @entity9 . The cyst was opened into basal cisterns with cystoperitoneal shunt. The histological examination revealed that it was an @entity1 . Six months later, the @entity0 was free of @entity8 @entity3 and head bobbing. Thus, we can assert that there was a direct relationship between this cyst and the @entity8 @entity3 . From this case, the authors make a review of the clinical features of @entity2 , and their different causes and show that both @entity2 and suprasellar @entity1 are not common.

title: XXXX with @entity9 in an @entity0 .

answer: @entity2


abstract: The authors report the case of a 2-year-old @entity0 who presented with @entity10 and short changes characterized by acute drowsiness, cold sweats, ocular reversion, @entity5 , and @entity6 . Between these attacks, the condition was normal, suggesting @entity8 @entity3 . Over 2 months five fits were observed by the parents when some to-and-fro bobbing of the head onto the trunk appeared during drowsiness. One electroencephalogram was normal without a slow background or spikes discharges. As the skull radiographs showed erosion of the jugum and chronic @entity4 features, a CT scan was performed and showed @entity7 associated with a @entity9 . The cyst was opened into basal cisterns with cystoperitoneal shunt. The histological examination revealed that it was an @entity1 . Six months later, the @entity0 was free of @entity8 @entity3 and head bobbing. Thus, we can assert that there was a direct relationship between this cyst and the @entity8 @entity3 . From this case, the authors make a review of the clinical features of @entity2 , and their different causes and show that both @entity2 and suprasellar @entity1 are not common.

title: @entity2 with @entity9 in an XXXX .

answer: @entity0


abstract: With standard microelectrode techniques, electrical activity of cells in the epicardial border zones of @entity4 in the @entity1 heart were studied. Either automaticity or triggered activity (or both) occurred in each of the 12 preparations studied from 24-hour @entity4 . One 24-hour preparation had continuous activity indistinguishable from low-potential (abnormal) automaticity. This automaticity was not effected by @entity6 1-5 mg/l. Two other 24-hour @entity0 also were automatic. However, nine preparations from the subepicardium were not automatic during superfusion with standard Tyrode's solution. @entity2 ( @entity2 ) and triggered activity could be induced in all of these preparations by treatment with @entity5 . The amplitude of these @entity2 was directly related to the stimulus rate of the train of impulses used to elicit them, and their coupling interval was inversely related to this rate of stimulation. Triggered activity occurred from maximal diastolic potentials of -58 to -88 mV in the 24-hour @entity4 zone preparations. In seven preparations from 72-96-hour @entity4 zones, the epicardial muscle cells did not show triggered activity after treatment with @entity5 . In one preparation from a 72-hour @entity4 , however, 3-5-mV @entity2 occurred. No @entity2 or triggered impulses occurred in subepicardial muscle from normal, noninfarcted hearts. Thus, triggered impulses and low-potential automaticity could contribute to @entity3 occurring in the @entity1 heart 24 hours after coronary ligation.

title: Automatic and triggered impulse initiation in @entity1 subepicardial ventricular muscle cells from border zones of 24-hour transmural XXXX . New mechanisms for malignant @entity3 ?

answer: @entity4


abstract: With standard microelectrode techniques, electrical activity of cells in the epicardial border zones of @entity4 in the @entity1 heart were studied. Either automaticity or triggered activity (or both) occurred in each of the 12 preparations studied from 24-hour @entity4 . One 24-hour preparation had continuous activity indistinguishable from low-potential (abnormal) automaticity. This automaticity was not effected by @entity6 1-5 mg/l. Two other 24-hour @entity0 also were automatic. However, nine preparations from the subepicardium were not automatic during superfusion with standard Tyrode's solution. @entity2 ( @entity2 ) and triggered activity could be induced in all of these preparations by treatment with @entity5 . The amplitude of these @entity2 was directly related to the stimulus rate of the train of impulses used to elicit them, and their coupling interval was inversely related to this rate of stimulation. Triggered activity occurred from maximal diastolic potentials of -58 to -88 mV in the 24-hour @entity4 zone preparations. In seven preparations from 72-96-hour @entity4 zones, the epicardial muscle cells did not show triggered activity after treatment with @entity5 . In one preparation from a 72-hour @entity4 , however, 3-5-mV @entity2 occurred. No @entity2 or triggered impulses occurred in subepicardial muscle from normal, noninfarcted hearts. Thus, triggered impulses and low-potential automaticity could contribute to @entity3 occurring in the @entity1 heart 24 hours after coronary ligation.

title: Automatic and triggered impulse initiation in @entity1 subepicardial ventricular muscle cells from border zones of 24-hour transmural @entity4 . New mechanisms for malignant XXXX ?

answer: @entity3


abstract: With standard microelectrode techniques, electrical activity of cells in the epicardial border zones of @entity4 in the @entity1 heart were studied. Either automaticity or triggered activity (or both) occurred in each of the 12 preparations studied from 24-hour @entity4 . One 24-hour preparation had continuous activity indistinguishable from low-potential (abnormal) automaticity. This automaticity was not effected by @entity6 1-5 mg/l. Two other 24-hour @entity0 also were automatic. However, nine preparations from the subepicardium were not automatic during superfusion with standard Tyrode's solution. @entity2 ( @entity2 ) and triggered activity could be induced in all of these preparations by treatment with @entity5 . The amplitude of these @entity2 was directly related to the stimulus rate of the train of impulses used to elicit them, and their coupling interval was inversely related to this rate of stimulation. Triggered activity occurred from maximal diastolic potentials of -58 to -88 mV in the 24-hour @entity4 zone preparations. In seven preparations from 72-96-hour @entity4 zones, the epicardial muscle cells did not show triggered activity after treatment with @entity5 . In one preparation from a 72-hour @entity4 , however, 3-5-mV @entity2 occurred. No @entity2 or triggered impulses occurred in subepicardial muscle from normal, noninfarcted hearts. Thus, triggered impulses and low-potential automaticity could contribute to @entity3 occurring in the @entity1 heart 24 hours after coronary ligation.

title: Automatic and triggered impulse initiation in XXXX subepicardial ventricular muscle cells from border zones of 24-hour transmural @entity4 . New mechanisms for malignant @entity3 ?

answer: @entity1


abstract: OBJECTIVE: 1) To characterize pediatric cochlear implant performance in @entity0 with @entity1 secondary to @entity2 . 2) To evaluate performance differences in @entity0 with and without @entity3 ( @entity3 ). STUDY DESIGN: Retrospective case review. SETTING: A large university-based multidisciplinary cochlear implant program. @entity0 : Forty-nine @entity0 with @entity1 from @entity2 who received cochlear implants from 1991 to 2011. Thirty-nine @entity0 had adequate data for analysis. INTERVENTION: Cochlear implantation with postoperative performance evaluation. MAIN OUTCOME MEASURE(S): Speech perception category (SPC). RESULTS: Nineteen (48.7%) @entity0 had intraoperative evidence of @entity3 . Fourteen @entity0 (70.0%) without @entity3 compared with seven (36.8%) with @entity3 developed open-set speech after implantation. There was a trend toward better postimplant SPC outcomes in @entity0 without @entity3 that did not reach statistical significance (p=0.17). The presence of @entity3 negatively correlated with classroom placement (p<0.05). Analysis of each group individually demonstrated statistically significant improvement in pre- versus postimplant SPC outcomes (p<0.001). CONCLUSION: The presence of @entity3 may negatively affect performance in pediatric @entity0 receiving a cochlear implant for @entity1 secondary to @entity2 .

title: The Impact of XXXX Ossificans on Speech Performance After Pediatric Cochlear Implantation.

answer: @entity3


abstract: STUDY DESIGN: Consecutive case-series OBJECTIVE.: The main purpose of this study was to analyse relationship between the preoperative @entity2 and subsequent survival of @entity0 undergoing surgical treatment for symptomatic spinal metastases. SUMMARY OF BACKGROUND DATA: The survival of @entity1 @entity0 has increased over recent years with improvements in oncologic therapy. As many as 70% of @entity1 @entity0 develop spinal metastases and approximately 10% of all @entity1 @entity0 are treated for metastatic @entity4 . METHODS: We retrospectively analysed 166 @entity0 who underwent surgery for symptomatic spinal metastases in our department between 2005 and 2012. The evaluated factors were age, primary @entity1 (slow, moderate, rapid growing), spinal location (cervical, thoracic, lumbar and sacral), operation type (posterior decompression, anterior or posterior instrumented procedure and radical combined instrumented surgery), pre-operative evaluation using revised Tokuhashi scoring system (below 9, 9-11 and 12-15), pre- and post-operative @entity2 according Frankel score (A-C and D-E), and the site of the main @entity4 (anterior, posterior or combined). @entity3 and recurrence rate was also monitored. RESULTS: The mean age of the @entity0 was 62  12 years. The median survival time after surgery was 16.0 months. Pre-operative @entity2 influenced survival time significantly; the median survival was 5.1 months in Frankel A-C and 28.2 months in Frankel D-E. (p<0.001). Improvement on the Frankel scale did not influence the survival time (p=0.131). When the @entity0 ' age was below 65 years this related to a significantly longer survival time (p=0.046). Tokuhashi score predicted @entity0 [Combining Acute Accent]s survival independently (p<0.001). The other factors had no statistical significance. CONCLUSIONS: The most important factors influencing post-operative survival time of these @entity0 with symptomatic spinal metastases was pre-operative @entity2 and Tokuhashi scoring system, which together represents a useful tool for planning the extent of surgical treatment. LEVEL OF EVIDENCE: 4.

title: Influence of the Pre-Operative Neurological Status on Survival after the Surgical Treatment of Symptomatic Spinal Metastases with XXXX .

answer: @entity4


abstract: STUDY DESIGN: Fusion success with rhBMP-2 and autograft in @entity1 or PEEK corpectomy devices was evaluated in a @entity2 lumbar corpectomy model. The 6 treatment groups included @entity1 mesh or PEEK corpectomy devices filled with rhBMP-2 on a compression-resistant matrix (CRM) carrier; rhBMP-2 in a morselized absorbable collagen sponge (ACS) carrier combined with resorbable ceramic granules; and autograft. OBJECTIVE: The aim of this study was to determine fusion rates associated with 2 different preparations of rhBMP-2 as well as autograft in an instrumented ovine lumbar corpectomy model 6 months postoperatively. SUMMARY OF BACKGROUND DATA: Vertebral reconstruction with corpectomy devices requires bone graft. Bone graft substitutes have the potential to avoid a second operation, donor site @entity0 , and attendant morbidity associated with autograft. METHODS: Twenty-four @entity2 in 6 treatment groups underwent lumbar corpectomy via a retroperitoneal trans-psoas approach. Spines were reconstructed with autograft, rhBMP-2 on a CRM, or rhBMP-2 on an ACS mixed with ceramic granules. Grafting materials were placed in either a @entity1 mesh or PEEK conduit in spines with internal fixation. Computed tomographic (CT) scans were evaluated for fusion. Undecalcified histology was used to evaluate for fusion as well as the amount and extent of graft incorporation and graft resorption. RESULTS: Regardless of corpectomy device used, rhBMP-2/CRM or rhBMP-2/ACS with MASTERGRAFT resulted in a 100% fusion rate. The autograft group had a lower (75%) radiographic fusion rate. Using either preparation of rhBMP-2 resulted in the length of the defect filling with solid bone. Autograft fragments and ceramic granules were incorporated into the fusion masses with much of the ceramic granules being resorbed by 6 months. CONCLUSION: Both of the rhBMP-2 formulations have the potential to effect bony fusion and vertebral reconstruction within the corpectomy devices. LEVEL OF EVIDENCE: N/A.

title: Instrumented Lumbar Corpectomy and Spinal Reconstruction Comparing rhBMP-2/Compression-Resistant Matrix, rhBMP-2/Absorbable Collagen Sponge/Ceramic Granules Mixture, and Autograft in Two Different Devices: A Study in XXXX .

answer: @entity2


abstract: The SCM test (structuredness of the cytoplasmic matrix) consists of measuring the fluorescence polarization of @entity3 which is introduced into a particular sub-group of peripheral lymphocytes. The test has a non-specific part for the general detection of @entity2 and a specificity procedure which is based on the use of specific @entity2 extracts. In this article we deal only with the latter in relation to @entity0 . Blood samples from 94 @entity1 have been tested; six of these had mastectomy performed previously; 83 underwent consecutively a surgical procedure and histology was obtained; five were only clinically examined. In 45/49 (92%) @entity1 , correlation between a positive specificity test and tissue @entity2 was found. Out of 35 @entity1 with non-malignant proliferative lesions (as found by histology), 25 reacted positively in the test. Two out of five @entity1 with non-malignant, non-proliferative lesions reacted positively in the test. Five @entity1 who were defined as normals by clinical examination reacted negatively in the test. These results indicate the potential of the SCM test for detecting @entity0 . The clinical implications of the test for @entity2 diagnosis are discussed.

title: An evaluation of the SCM test for the diagnosis of XXXX .

answer: @entity0


abstract: A new intraoperative approach to @entity1 localization using radiolabelled monoclonal antibody (MAb) B72.3 involves the use of a hand-held gamma-detecting probe ( @entity6 ) by the surgeon and, subsequently, the pathologist. We report here the use of 125I-labelled MAb B72.3 IgG and a @entity6 to localize primary and metastatic @entity2 in 31 @entity0 . The @entity0 were administered radiolabelled MAb i.v., and all underwent surgical exploration 5 to 35 days post-injection. In vivo localization of the MAb was evaluated using a @entity6 , with @entity1 and normal tissue counts being obtained. In each case, the subsequent @entity1 and normal tissue that were resected were analyzed in vitro for MAb localization; this was evaluated by calculating the radiolocalization index, i.e., the ratio of the injected dose per gram localized to @entity1 versus that of normal tissue. When the @entity6 was used intraoperatively, MAb B72.3 localized @entity1 in 68% (21/31) of the @entity0 ; the arbitrary criterion of @entity1 -to-normal tissue ratios higher than or equal to 2.0:1 in vivo being taken as positive. Resected @entity1 radiolocalization indices ranged from 0.5 to 543, and 71% (22/31) of the @entity0 studied had @entity1 with radiolocalization indices higher than or equal to 3. Of 50 @entity4 biopsies, 34 that were probe-positive were antigen-positive when B72.3 was used in immunoperoxidase assays, while 4 @entity4 biopsies that were probe-negative were also antigen-negative. Twelve of 50 biopsies were probe-negative and antigen-positive, but many of these lesions only contained a few antigen-positive cells; none of the 50 was probe-positive and antigen-negative. Tumors of all histologic grades localized injected MAb and, in general, higher in vivo probe ratios and radiolocalization indices were obtained from @entity0 who underwent surgery 20 to 35 days following injection of the MAb. MAb B72.3 localized @entity1 in all sites to which @entity5 commonly metastasizes, including mesenteric and peri-aortic lymph nodes, liver, lung, and peri-rectal soft tissue. There was a strong statistical correlation (p = 0.001) between detecting MAb B72.3 localization to @entity1 using the @entity6 intraoperatively and subsequent in vitro analysis of cpm/g for @entity1 versus normal tissues. These studies thus further validate the use of 125I-labelled MAb B72.3 IgG and of a hand-held gamma probe for the intraoperative detection of @entity3 .

title: Intraoperative radioimmunolocalization of XXXX with a hand-held gamma probe and MAb B72.3: comparison of in vivo gamma probe counts with in vitro MAb radiolocalization.

answer: @entity2


abstract: OBJECTIVE: To analyze the therapeutic effect of proton pump inhibitor(PPI) on alleviation of hoarseness symptoms in @entity0 with laryngopharyngeal reflux(LPR). METHOD: The LPR outpatients in ENT department of our hospital(60 cases)complained of hoarseness were enrolled in the study from August of 2013 to October of 2014. All of them were randomly divided into group A and B. The individuals in group A (30 cases) taked golden voice capsule to treat for 3 months, while the individuals in group B (30 cases) taked golden voice capsule and @entity3 to treat for 3 months. The data about @entity2 ( @entity2 ), @entity1 ( @entity1 ) and voice handicap index (VHI)from the first month to the third month after treatment were recorded and compared group A with group B. RESULT: The scores of @entity2 and @entity1 in @entity0 (60 cases) before treatment were significantly correlated with their VHI (r=0. 823, P<0. 01; r=0. 873, P<0. 01). The score changes of @entity2 and VHI from the first to the third month after treatment in group B were significantly higher than those in group A (P<0. 01). Meanwhile, the score changes of @entity1 from the third month after treatment in group B were significantly higher than those in group A (t=8. 307, P<. 01), but the differences were not significant for @entity1 from the first to the second month after treatment between group A and group B(t=1. 128, P>0. 05; t=0. 376, P> 0. 05). CONCLUSION: PPI therapy could significantly alleviate the hoarseness symptom in LPR @entity0 .

title: [The therapeutic effect of proton pump inhibitor on alleviation of hoarseness symptoms in XXXX with laryngopharyngeal reflux].

answer: @entity0


abstract: OBJECTIVE: To study the assessed value of 64 slice spiral CT perfusion imaging (CTPI) in @entity2 after chemotherapy and radiotherapy. METHOD: Forty five @entity0 diagnosed with local advanced @entity2 were selected. Conventional CT and CTPI were performed before treatment and at the time of radiation dose up to 40 Gy. Blood flow, blood volume, mean transit time and surface permeability were measured at the same time. According to the decrease of @entity1 volume in final examination, @entity0 were divided into sensitive group and insensitive group. The @entity1 perfusion indexes were compared between groups. RESULT: Blood flow, blood volume, surface permeability after 40Gy treatment were lower than before treatment in both sensitive group and the insensitive group ascended(P<0. 05). The AUC of ROC of blood flow, blood volume, mean transit time and surface permeability were 0. 804, 0. 843, 0. 852 and 0. 826. The sensitivity, specificity and accuracy of blood flow was 89. 7%, 86.8% and 90. 9%. There were 100. 0%, 91. 4% and 93. 7% in blood volume; 100. 0%, 67. 7% and 88. 3% in mean transit time; 91. 2%, 69. 4% and 90. 6% in surface permeability(P<0. 01). CONCLUSION: Sixty-four slice spiral CT perfusion imaging is able to assess @entity1 status of @entity2 after chemotherapy and radiotherapy effectively.

title: [The assessed value of 64 slice spiral CT perfusion imaging in XXXX after chemotherapy and radiotherapy].

answer: @entity2


abstract: BACKGROUND: Chondral or @entity3 have been reported in 60-67  % of @entity0 in studies reporting knee arthroscopies. The surgical management of chondral and @entity3 ( @entity3 ) of the articular surface of the knee joint remains a controversial topic. @entity1 can be treated with transfer cartilage procedure and with implantation of biodegradable scaffolds. For @entity0 over 50  years old with largest osteochondral lesions, we prefer to use the biodegradable scaffold, like Trufit(  ) plug (Smith _ Nephew, Andover, MA). The purpose of this study is to evaluate the outcome of this series of surgical procedure with Trufit. METHODS: In our institute, the Trufit was used for the treatment of one or more focal osteochondral lesions of the femoral condyles positive MRI with or without concomitant ligamentous or meniscal pathology. We reviewed 30 @entity0 with mean age of 60.57  years (range 32-79  years) with a clinical and imaging control at 6, 12, 24 and 48  months of follow-up. RESULTS: The clinical evaluation has shown the good outcome. The MRI conducted has shown the progressive partial integration of the scaffolds. CONCLUSIONS: The results obtained indicate a clear improvement of the clinical symptoms and @entity2 . The clinical and imaging results confirm that the Trufit constitutes a valid surgical alternative in case of focal osteochondral.

title: The biphasic bioresorbable scaffold (Trufit(  )) in the osteochondral knee lesions: long-term clinical and MRI assessment in 30 XXXX .

answer: @entity0


abstract: After a discussion of the changes of the @entity6 concept over the years, the authors describe their own investigation of a total sample of 3280 @entity0 , attending outpatient and inpatient facilities of three counties with a total population of 574,000 inhabitants. The aim of the study was to investigate the frequency, sex distribution, and social class dependency of the @entity6 -diagnosis and its relationship to @entity3 . The following results were obtained: There is a strong correlation of @entity6 -diagnosis with age, sex, and social class. @entity6 was most frequently diagnosed in the age groups of 3-6, 6-9 and 9-12 years, being twice as frequent in @entity0 than in @entity0 and dominating among the lower social classes. The frequency of @entity6 in the total sample was 11%, taking into consideration all age-classes. @entity6 was significantly associated only with two @entity3 syndromes: @entity10 and @entity1 . There was no correlation with @entity2 or @entity11 , however, a very strong one with @entity4 in development, defined according to the multiaxial classification system. 72% of the @entity0 diagnosed as @entity6 - @entity0 revealed @entity4 in development. But this high correlation was caused only by two conditions: developmental speech/ @entity7 and specific @entity5 . There was no correlation between @entity6 and specific @entity9 nor with other specific @entity8 or mixed @entity4 . Future research in this field should look upon the so-called @entity6 more in terms of general developmental delays than in terms of brain pathology.

title: [Minimal brain dysfunction--on the revision of a clinical concept. Clinical data of a total pediatric and adolescent XXXX @entity0 population].

answer: @entity3


abstract: After a discussion of the changes of the @entity6 concept over the years, the authors describe their own investigation of a total sample of 3280 @entity0 , attending outpatient and inpatient facilities of three counties with a total population of 574,000 inhabitants. The aim of the study was to investigate the frequency, sex distribution, and social class dependency of the @entity6 -diagnosis and its relationship to @entity3 . The following results were obtained: There is a strong correlation of @entity6 -diagnosis with age, sex, and social class. @entity6 was most frequently diagnosed in the age groups of 3-6, 6-9 and 9-12 years, being twice as frequent in @entity0 than in @entity0 and dominating among the lower social classes. The frequency of @entity6 in the total sample was 11%, taking into consideration all age-classes. @entity6 was significantly associated only with two @entity3 syndromes: @entity10 and @entity1 . There was no correlation with @entity2 or @entity11 , however, a very strong one with @entity4 in development, defined according to the multiaxial classification system. 72% of the @entity0 diagnosed as @entity6 - @entity0 revealed @entity4 in development. But this high correlation was caused only by two conditions: developmental speech/ @entity7 and specific @entity5 . There was no correlation between @entity6 and specific @entity9 nor with other specific @entity8 or mixed @entity4 . Future research in this field should look upon the so-called @entity6 more in terms of general developmental delays than in terms of brain pathology.

title: [Minimal brain dysfunction--on the revision of a clinical concept. Clinical data of a total pediatric and adolescent @entity3 XXXX population].

answer: @entity0


abstract: BACKGROUND: Assessment blood consumption and @entity1 -associated severe @entity3 scores are useful for predicting the need for @entity2 ( @entity2 ) in severe @entity1 @entity0 . However, @entity4 ( @entity4 ) and base excess (BE) levels might also be useful indicators for the need for @entity2 . We evaluated the accuracy of prediction for @entity2 of the scoring system vs. @entity4 and BE. METHODS: The subjects of this retrospective single center observational study were @entity0 with injury severity score >= 16 @entity1 , divided into a non- @entity2 group and an @entity2 group. We compared variables, including the scoring system (comprising vital signs and focused assessment with sonography for @entity1 ; FAST) and @entity4 between the groups. We then performed a multiple logistic regression modeling and a receiver operating characteristic analysis to clarify which value was the most useful predictive indicator for @entity2 . RESULTS: There were 114 @entity0 in the non- @entity2 group and 39 in the @entity2 group. The level of @entity4 and BE were independent predictors of @entity2 . The area under the curve values for @entity4 and BE were 0.765 and 0.845, respectively, and the optimal cutoff values of @entity4 and BE were 211  mg/dL and -1.4, respectively. CONCLUSIONS: @entity4 and BE levels can be used as an independent predictor for @entity2 .

title: @entity4 and base excess levels as predictive markers of the need for massive blood transfusion after blunt XXXX .

answer: @entity1


abstract: BACKGROUND: Assessment blood consumption and @entity1 -associated severe @entity3 scores are useful for predicting the need for @entity2 ( @entity2 ) in severe @entity1 @entity0 . However, @entity4 ( @entity4 ) and base excess (BE) levels might also be useful indicators for the need for @entity2 . We evaluated the accuracy of prediction for @entity2 of the scoring system vs. @entity4 and BE. METHODS: The subjects of this retrospective single center observational study were @entity0 with injury severity score >= 16 @entity1 , divided into a non- @entity2 group and an @entity2 group. We compared variables, including the scoring system (comprising vital signs and focused assessment with sonography for @entity1 ; FAST) and @entity4 between the groups. We then performed a multiple logistic regression modeling and a receiver operating characteristic analysis to clarify which value was the most useful predictive indicator for @entity2 . RESULTS: There were 114 @entity0 in the non- @entity2 group and 39 in the @entity2 group. The level of @entity4 and BE were independent predictors of @entity2 . The area under the curve values for @entity4 and BE were 0.765 and 0.845, respectively, and the optimal cutoff values of @entity4 and BE were 211  mg/dL and -1.4, respectively. CONCLUSIONS: @entity4 and BE levels can be used as an independent predictor for @entity2 .

title: XXXX and base excess levels as predictive markers of the need for massive blood transfusion after blunt @entity1 .

answer: @entity4


abstract: UNASSIGNED: The 24-hour urine collection method is considered the gold standard for the estimation of ingested @entity1 and @entity2 . Because of the impracticalities of collecting all urine over a 24-hour period, spot urine is often used for epidemiological investigations. This study aims to assess the agreement between spot urine and 24-hour urine measurements to determine @entity2 and @entity1 intake. A total of 402 @entity0 aged 25 to 64 years were randomly selected in South Benin. Spot urine was taken during the second urination of the day. Twenty-four-hour urine was also collected. Samples (2-mL) were taken and then stored at -20  C. The analysis was carried out using potentiometric dosage. The agreement between spot urine and 24-hour urine measurements was established using Bland-Altman plots. A total of 354 results were analyzed. Daily @entity3 and @entity4 urinary excretion means were 10.2  4.9 g/24 h and 2.9  1.4 g/24 h, respectively. Estimated daily @entity3 and @entity4 means from the spot urine were 10.7  7.0 g/24 h and 3.9  2.1 g/24 h, respectively. Concordance coefficients were 0.61 at d=-0.5 g, (d  2SD=-11 g and 10.1 g) for @entity3 and 0.61 at d=-1 g, (d  2SD=-3.8 g and 1.8 g) for @entity4 . Spot urine method is acceptable for estimating 24-hour urinary @entity2 and @entity1 excretion to assess @entity2 and @entity1 intake in a black population. However, the confidence interval for the mean difference, which is too large, makes the @entity3 results inadmissible at a clinical level.

title: Estimation of Daily @entity2 and XXXX Excretion Using Spot Urine and 24-Hour Urine Samples in a Black Population (Benin).

answer: @entity1


abstract: UNASSIGNED: The 24-hour urine collection method is considered the gold standard for the estimation of ingested @entity1 and @entity2 . Because of the impracticalities of collecting all urine over a 24-hour period, spot urine is often used for epidemiological investigations. This study aims to assess the agreement between spot urine and 24-hour urine measurements to determine @entity2 and @entity1 intake. A total of 402 @entity0 aged 25 to 64 years were randomly selected in South Benin. Spot urine was taken during the second urination of the day. Twenty-four-hour urine was also collected. Samples (2-mL) were taken and then stored at -20  C. The analysis was carried out using potentiometric dosage. The agreement between spot urine and 24-hour urine measurements was established using Bland-Altman plots. A total of 354 results were analyzed. Daily @entity3 and @entity4 urinary excretion means were 10.2  4.9 g/24 h and 2.9  1.4 g/24 h, respectively. Estimated daily @entity3 and @entity4 means from the spot urine were 10.7  7.0 g/24 h and 3.9  2.1 g/24 h, respectively. Concordance coefficients were 0.61 at d=-0.5 g, (d  2SD=-11 g and 10.1 g) for @entity3 and 0.61 at d=-1 g, (d  2SD=-3.8 g and 1.8 g) for @entity4 . Spot urine method is acceptable for estimating 24-hour urinary @entity2 and @entity1 excretion to assess @entity2 and @entity1 intake in a black population. However, the confidence interval for the mean difference, which is too large, makes the @entity3 results inadmissible at a clinical level.

title: Estimation of Daily XXXX and @entity1 Excretion Using Spot Urine and 24-Hour Urine Samples in a Black Population (Benin).

answer: @entity2


abstract: BACKGROUND _ AIMS: @entity1 is a complex acquired @entity4 and frequent indication for transfusion of blood components. We characterised blood component use in @entity0 with @entity1 and compared this to transfusion guidelines. METHODS: All National Health Service trusts with representation on the British Society of Gastroenterology membership list were invited to take part. Data were collected prospectively on consecutive, unselected, hospitalised admissions with @entity1 over 28 days. Detailed information was recorded for @entity0 receiving blood components including indication (for @entity2 or prophylaxis), type of component, laboratory indices triggering transfusion, complications, @entity3 events and clinical outcome to day 28. RESULTS: Data on 1313 consecutive @entity0 with @entity1 were collected from 85 hospitals. 391/1313 (30%) were transfused a blood component; in 238/391 (61%) this was for treatment of @entity2 and in 153/391 (39%) for prophylaxis of @entity2 . In 48/185 (26%) cases with @entity2 , the haemoglobin threshold was >80g/L prior to red blood cell transfusion. In the prophylaxis group 238/391 (61%) received transfusion in response to an abnormal haematological value, in the absence of any planned procedure. In @entity0 transfused for procedural prophylaxis 10/34 (29%) received fresh frozen plasma at an International Normalised Ratio lower than the threshold where a benefit would be anticipated. An in- @entity0 @entity3 event was recorded in 3% (35/1313) and 10% (138/1313) died by day 28. CONCLUSIONS: One-third of hospitalised @entity0 with @entity1 were transfused. Strategies for @entity0 Blood Management should include ensuring transfusion practice is consistent with guidelines and greater emphasis on alternatives to transfusion. This article is protected by copyright. All rights reserved.

title: Patterns of blood component use in XXXX : a nationwide study.

answer: @entity1


abstract: PURPOSE: This study was designed to evaluate the value of resection and to analyze clinicopathologic data on @entity2 @entity0 who were evaluated as curable preoperatively but diagnosed as advanced intraoperatively. METHODS: A retrospective analysis was performed on clinical, surgical, and pathological data of 264 @entity0 who had undergone surgery for @entity2 between January 2008 and October 2012. The @entity0 who were diagnosed in advanced stages during surgical exploration were accepted into the study group. @entity0 were categorized into the following two groups: non-resection group (NRG) and resection group (RG). We compared the clinicopathologic features of the two groups and investigated the prognostic factors by performing univariate and multivariate analyses. RESULTS: A total of 79 @entity0 diagnosed with advanced disease in surgical exploration were evaluated. There were 40 @entity0 (50.6%) in the NRG and 39 @entity0 (49.4%) in the RG. The difference in median overall survival between the NRG and the RG was statistically significant (1.7 vs 5 months; p=0.001). In multivariate analysis, age less than 70 years, gastric resection, adjuvant chemotherapy, and male gender were found to be favorable significant independent prognostic factors for overall survival. Conlusion: Resection seems to be associated with improved overall survival in @entity0 who were diagnosed as advanced intraoperatively. Therefore, @entity0 and @entity1 -related factors should be taken into consideration before planning resection. Randomized controlled studies are required.

title: Is resection indicated in XXXX deemed curable preoperatively but found to be advanced intraoperatively?

answer: @entity2


abstract: BACKGROUND: The purpose of this study was to examine the incidence of adverse events in elderly @entity0 who required inpatient admission after sustaining an @entity3 and to consider these data in relation to @entity1 and other geriatric @entity0 admissions. METHODS: A retrospective cohort study of @entity0 admitted with an @entity3 , a @entity1 , or any other diagnosis was performed with the Medicare Part A database for 2008. The primary outcome measure was the one-year mortality rate, examined with multivariate analysis factoring for both @entity0 age and preexisting comorbidity. Secondary outcome measures analyzed additional morbidity as reflected by length of stay, discharge disposition, readmissions, and medical complications. RESULTS: There were 19,648 @entity0 with @entity3 , 193,980 @entity0 with @entity1 , and 5,801,831 @entity0 with other admitting diagnoses. Significant differences (p < 0.001) were noted in both age and comorbidity status between the group with @entity3 and the group with @entity1 . The one-year mortality after admission was 11.9% for @entity0 with @entity3 , 28.2% for @entity0 with @entity1 , and 21.5% for @entity0 with any other admission. Upon using multivariate analysis to account for both age and comorbidity, the hazard ratio for one-year mortality associated with @entity2 was 1.088 for @entity0 with @entity1 and 0.557 for @entity0 with @entity3 . CONCLUSIONS: Even after selecting for admitted @entity0 and accounting for both age and comorbidity, geriatric @entity0 with @entity3 were found to have a lower one-year morbidity compared with geriatric @entity0 who had sustained a @entity1 or alternative admitting diagnoses. Geriatric @entity0 with @entity3 are likely healthier and more active in ways that are not captured by simply accounting for age and comorbidity. These findings may support more aggressive definitive management of such injuries in this population. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

title: Morbidity and Mortality Associated with XXXX : A Medicare Part A Claims Database Analysis.

answer: @entity3


abstract: OBJECTIVE: The goal of this study was to explore whether the tool-use disorders observed in @entity2 ( @entity2 ) and @entity4 ( @entity4 ) are of the same nature as those observed in @entity1 ( @entity1 ) @entity0 . Recent evidence indicates that @entity1 @entity0 with @entity3 of tool use encounter difficulties in solving mechanical problems, characterized by the absence of specific strategies. This pattern may show the presence of impaired mechanical knowledge, critical for both familiar and novel tool use. So, we explored the strategies followed by @entity2 and @entity4 @entity0 in mechanical problem-solving tasks in order to determine whether mechanical knowledge is also impaired in these @entity0 . METHOD: We used a mechanical problem-solving task in both choice (i.e., several tools were proposed) and no-choice (i.e., only 1 tool was proposed) conditions. We analyzed quantitative data and strategy profiles. RESULTS: @entity2 @entity0 but not @entity4 @entity0 met difficulties in solving mechanical problem-solving tasks. However, the key finding is that @entity2 @entity0 , despite their difficulties, showed strategy profiles that are similar to that of @entity4 @entity0 or controls. Moreover, @entity2 @entity0 exhibited a strategy profile distinct from the one previously observed in @entity1 @entity0 . CONCLUSIONS: Those observations lead us to consider that difficulties met by @entity2 @entity0 to solve mechanical problems or even to use familiar tools may not be caused by mechanical knowledge impairment per se. In broad terms, what we call @entity3 of tool use in @entity2 is certainly not the same as @entity3 of tool use observed in @entity1 @entity0 . (PsycINFO Database Record

title: Mechanical Problem-Solving Strategies in XXXX and @entity4 .

answer: @entity2


abstract: OBJECTIVE: The goal of this study was to explore whether the tool-use disorders observed in @entity2 ( @entity2 ) and @entity4 ( @entity4 ) are of the same nature as those observed in @entity1 ( @entity1 ) @entity0 . Recent evidence indicates that @entity1 @entity0 with @entity3 of tool use encounter difficulties in solving mechanical problems, characterized by the absence of specific strategies. This pattern may show the presence of impaired mechanical knowledge, critical for both familiar and novel tool use. So, we explored the strategies followed by @entity2 and @entity4 @entity0 in mechanical problem-solving tasks in order to determine whether mechanical knowledge is also impaired in these @entity0 . METHOD: We used a mechanical problem-solving task in both choice (i.e., several tools were proposed) and no-choice (i.e., only 1 tool was proposed) conditions. We analyzed quantitative data and strategy profiles. RESULTS: @entity2 @entity0 but not @entity4 @entity0 met difficulties in solving mechanical problem-solving tasks. However, the key finding is that @entity2 @entity0 , despite their difficulties, showed strategy profiles that are similar to that of @entity4 @entity0 or controls. Moreover, @entity2 @entity0 exhibited a strategy profile distinct from the one previously observed in @entity1 @entity0 . CONCLUSIONS: Those observations lead us to consider that difficulties met by @entity2 @entity0 to solve mechanical problems or even to use familiar tools may not be caused by mechanical knowledge impairment per se. In broad terms, what we call @entity3 of tool use in @entity2 is certainly not the same as @entity3 of tool use observed in @entity1 @entity0 . (PsycINFO Database Record

title: Mechanical Problem-Solving Strategies in @entity2 and XXXX .

answer: @entity4


abstract: The complete @entity0 sequence of the intergenic region between the 25 S and 18 S wheat ribosomal RNA genes has been determined from a 4.6 kb EcoRI-BamHI fragment (1 kb = 10(3) bases or base-pairs) subcloned from the plasmid pTa71. Within this subclone the intergenic DNA is flanked by the 3' end of the 25 S and the 5' end of the 18 S ribosomal RNA sequences. Four repeat families are present within the intergenic region. The major repeat family A, consists of 12 direct repeat units of 135 or 136 base-pairs (bp) flanked by diverged truncated copies. Within each A repeat a subrepeat structure has been revealed. Family B, which is localized to the 5' side of the A repeats, contains three repeat units, one of 152 bp, the second of 150 bp and a truncated unit of 107 bp. Family C, which is localized in the transcribed rRNA precursor, consists of two direct repeat units of 172 and 174 bp and possesses some short subrepeat motifs. The C repeats may have evolved by and diverged from one another by the insertion of short transposable sequences. Family D consists of two direct repeat units of 30 bp located 5' to the start of transcription. Statistical analysis of repeat family A showed that there is a significant association between the similarity of any two repeat units and their distance apart in the array. The near identity of members of the A family is maintained presumably by processes such as unequal crossing over and gene conversion, but the members at each end of the array show more divergence. Sequence motifs in the A and C repeat families and in other regions including the 5' end of 18 S RNA are related, implying that much of the intergenic DNA may have evolved from a few short ancestral sequences. The B and D repeats or their equivalent are not found in a @entity1 ribosomal DNA repeat unit. The DNA in the external transcribed spacer DNA 5' to the 18 S RNA sequence is longer in @entity2 than in @entity1 . This is due principally to two duplications and insertion of a sequence with dyad symmetry in the @entity2 gene.

title: Structure and evolution of the intergenic region in a ribosomal DNA repeat unit of XXXX .

answer: @entity2


abstract: PURPOSE: The feasibility of defining early @entity4 has not been adequately evaluated. The surgical outcomes of @entity0 who had undergone pancreatoduodenectomy (PD) for pathological T1 (pT1) distal @entity4 (DCC) were evaluated to determine whether it is possible to define early DCC. METHODS: The clinicopathological data of 18 @entity0 with pT1 DCC who had undergone PD were reviewed retrospectively. Depth of fibromuscular (fm) layer invasion was divided into two categories: fm1 and fm2 (without @entity1 and with @entity1 ). Comparative analyses were performed according to the depth of invasion. RESULTS: Disease-specific survival rates of @entity0 with five @entity2 and 13 fm-invasive @entity2 were 80 and 61.9  % at 5  years and 80 and 41.2  % at 10  years, respectively. There was no significant difference in disease-specific survival rates between the two groups (P   =   0.244). Disease-specific survival rates of @entity0 with 7 fm1-invasive @entity2 and 6 fm2-invasive @entity2 were 85.7 and 40  % at 5  years and 85.7 and 0  % at 10  years. A significant difference in disease-specific survival rates was observed between @entity2 and fm2-invasive @entity2 (P   =   0.043), and disease-specific survival rates of @entity2 and fm1-invasive @entity2 were similar (P   =   0.968). CONCLUSIONS: Defining early DCC as @entity3 confined to the fm of the bile duct might be inappropriate; early DCC should be limited to the @entity5 .

title: Is it possible to define early distal XXXX ?

answer: @entity4


abstract: Secretory phospholipase A(2) ( @entity4 ) exhibits @entity3 in the central nervous system. There are high-affinity binding sites of the porcine pancreatic group IB @entity4 ( @entity4 ) in the brain. @entity4 causes neuronal cell death via apoptosis in the @entity0 cerebral cortex. Although apoptosis is triggered by an influx of @entity1 into neurons, it has not yet been ascertained whether the @entity1 influx is associated with the @entity3 of @entity4 . We thus examined the possible involvement of @entity1 in the @entity3 of @entity4 in the primary culture of @entity0 cortical neurons. @entity4 induced neuronal cell death in a concentration- and time-dependent manner. This death was accompanied by condensed chromatin and fragmented DNA, exhibiting apoptotic features. Before apoptosis, @entity4 markedly enhanced the influx of @entity1 into neurons. A @entity2 chelator suppressed neurons from @entity4 -induced neuronal cell death in a concentration-dependent manner. An L-type voltage-sensitive @entity1 channel (L-VSCC) blocker significantly protected the @entity4 -potentiated influx of @entity1 . On the other hand, blockers of N-VSCC and P/Q-VSCC did not. An L-VSCC blocker protected neurons from @entity4 -induced neuronal cell death. In addition, the L-VSCC blocker ameliorated the apoptotic features of @entity4 -treated neurons. Neither an N-VSCC blocker nor P/Q-VSCC blockers affected the @entity3 of the enzyme. In conclusion, these findings demonstrate that the influx of @entity1 into neurons play an important role in the @entity3 of @entity4 . Furthermore, the present study suggests that L-VSCC contribute to the @entity4 -potentiated influx of @entity1 into neurons.

title: Porcine pancreatic group IB secretory phospholipase A2 potentiates XXXX influx through L-type voltage-sensitive @entity1 channels.

answer: @entity1


abstract: Secretory phospholipase A(2) ( @entity4 ) exhibits @entity3 in the central nervous system. There are high-affinity binding sites of the porcine pancreatic group IB @entity4 ( @entity4 ) in the brain. @entity4 causes neuronal cell death via apoptosis in the @entity0 cerebral cortex. Although apoptosis is triggered by an influx of @entity1 into neurons, it has not yet been ascertained whether the @entity1 influx is associated with the @entity3 of @entity4 . We thus examined the possible involvement of @entity1 in the @entity3 of @entity4 in the primary culture of @entity0 cortical neurons. @entity4 induced neuronal cell death in a concentration- and time-dependent manner. This death was accompanied by condensed chromatin and fragmented DNA, exhibiting apoptotic features. Before apoptosis, @entity4 markedly enhanced the influx of @entity1 into neurons. A @entity2 chelator suppressed neurons from @entity4 -induced neuronal cell death in a concentration-dependent manner. An L-type voltage-sensitive @entity1 channel (L-VSCC) blocker significantly protected the @entity4 -potentiated influx of @entity1 . On the other hand, blockers of N-VSCC and P/Q-VSCC did not. An L-VSCC blocker protected neurons from @entity4 -induced neuronal cell death. In addition, the L-VSCC blocker ameliorated the apoptotic features of @entity4 -treated neurons. Neither an N-VSCC blocker nor P/Q-VSCC blockers affected the @entity3 of the enzyme. In conclusion, these findings demonstrate that the influx of @entity1 into neurons play an important role in the @entity3 of @entity4 . Furthermore, the present study suggests that L-VSCC contribute to the @entity4 -potentiated influx of @entity1 into neurons.

title: Porcine pancreatic group IB secretory phospholipase A2 potentiates @entity1 influx through L-type voltage-sensitive XXXX channels.

answer: @entity1


abstract: Oxidative stress plays an important role in causing progressive @entity6 ( @entity6 ). We examined the influence of add-on ANG II receptor blockade administered as @entity12 (50 mg/day for 1 mo) on oxidative stress and proinflammatory state of the kidney in @entity0 with @entity6 . All subjects were taking an angiotensin-converting enzyme inhibitor plus other antihypertensive agents. Oxidative stress to lipids and proteins was measured by an HPLC assay for @entity8 ( @entity9 ) and @entity11 concentration, respectively. Urinary @entity3 was measured by @entity10 ( @entity10 ) excretion rate. The etiology of @entity6 was @entity1 in 12 and @entity4 in 4 @entity0 . There was no change in @entity5 or 24-h ambulatory blood pressure (BP) with add-on ANG II receptor blockade with @entity12 therapy. Before @entity12 therapy, urinary protein and albumin oxidation were 99 and 71% higher, respectively, compared with in plasma (P < 0.05). There was a 35% reduction in urinary oxidized albumin with add-on @entity12 therapy (P = 0.036). Urinary and plasma @entity9 were elevated compared with age-matched controls. Urinary @entity9 was significantly reduced from 4.75 +/- 3.23 to 3.39 +/- 2.17 micromol/g @entity7 with add-on @entity12 therapy. However, plasma @entity9 or oxidized proteins did not change in response to additional ANG II blockade. A good correlation was seen between the change in urinary oxidized albumin and @entity10 levels (r = 0.61, P = 0.012). These data demonstrate that oxidative damage to urinary protein and lipids can be reduced with additional ANG II receptor blockade, independently of reductions in @entity5 or BP. Urinary measurements of markers of oxidative damage to lipids and proteins appear to be more sensitive than plasma measurements in @entity0 with @entity6 . The significant association of the change in urinary @entity10 with a reduction in oxidative stress supports the role of the redox state in the kidney with @entity2 .

title: Proinflammatory effects of oxidative stress in XXXX : role of additional angiotensin II blockade.

answer: @entity6


abstract: Insular cortex (IC) receives inputs from multiple sensory systems, including taste, and from receptors that monitor body electrolyte and fluid balance and blood pressure. This work analyzed metabolic activity of IC cells after water and @entity2 ingestion induced by @entity2 depletion. @entity0 were injected with the diuretic @entity3 (10 mg/kg body wt), followed 5 min later by injections of the angiotensin-converting enzyme inhibitor @entity4 (5 mg/kg body wt). After 90 min, some @entity0 received water and 0.3 M @entity1 to drink for 2 h while others did not. A third group had access to water and saline but was not depleted of fluids. All @entity0 were killed for processing of brain tissue for @entity5 -immunoreactivity ( @entity5 -ir). Nondepleted animals had weak-to-moderate levels of @entity5 -ir within subregions of IC. Fluid-depleted @entity0 without fluid access had significantly increased @entity5 -ir in all areas of IC. Levels of @entity5 -ir were highest in fluid-depleted @entity0 that drank water and @entity2 . @entity5 -ir levels were highest in anterior regions of IC and lowest in posterior regions of IC. These results implicate visceral, taste, and/or postingestional factors in the increased metabolic activity of cells in IC.

title: Increased cellular activity in XXXX insular cortex after water and salt ingestion induced by fluid depletion.

answer: @entity0


abstract: BACKGROUND: Selective @entity5 ( @entity5 ) blockade is one option to decrease acute rejection rates in kidney transplant recipients. However, there are little data on the impact of basiliximab in a triple immunosuppressive regimen ( @entity4 , @entity2 , and low-dose @entity1 ). Thus, this analysis aims at investigating the impact of basiliximab induction on rejection rates and immediate graft function following kidney transplantation. METHODS: Basiliximab was introduced in our center according to our center's policy in the beginning of 2011. @entity0 who received basiliximab (n  = 83) were compared with @entity0 without induction therapy (n  = 65) transplanted before the introduction of @entity5 antibody induction. RESULTS: The use of basiliximab as induction therapy decreased the incidence of biopsy-proven acute rejection (BPAR) within the 1st year after transplantation (21.5% vs 14.5%; P  = .283). Overall rejection episodes (including BPAR and borderline rejection) were significantly reduced in @entity0 with basiliximab compared with @entity0 without (41.5% vs 24.1%; P  = .033). However, graft function (incidence of delayed graft function, primary nonfunction, slow graft function, and serum @entity3 decline) and overall outcome ( @entity0 and graft survivals) were similar in both groups. CONCLUSIONS: We found a favorable impact of basiliximab induction therapy on early acute rejection rate. The impact on long-term outcome must be addressed in further randomized controlled trials.

title: @entity4 , Mycophenolate Mofetil, and Low-Dose XXXX With or  Without Interleukin-2 Receptor Antibody Induction Therapy: A  Retrospective Cohort Analysis.

answer: @entity1


abstract: BACKGROUND: Selective @entity5 ( @entity5 ) blockade is one option to decrease acute rejection rates in kidney transplant recipients. However, there are little data on the impact of basiliximab in a triple immunosuppressive regimen ( @entity4 , @entity2 , and low-dose @entity1 ). Thus, this analysis aims at investigating the impact of basiliximab induction on rejection rates and immediate graft function following kidney transplantation. METHODS: Basiliximab was introduced in our center according to our center's policy in the beginning of 2011. @entity0 who received basiliximab (n  = 83) were compared with @entity0 without induction therapy (n  = 65) transplanted before the introduction of @entity5 antibody induction. RESULTS: The use of basiliximab as induction therapy decreased the incidence of biopsy-proven acute rejection (BPAR) within the 1st year after transplantation (21.5% vs 14.5%; P  = .283). Overall rejection episodes (including BPAR and borderline rejection) were significantly reduced in @entity0 with basiliximab compared with @entity0 without (41.5% vs 24.1%; P  = .033). However, graft function (incidence of delayed graft function, primary nonfunction, slow graft function, and serum @entity3 decline) and overall outcome ( @entity0 and graft survivals) were similar in both groups. CONCLUSIONS: We found a favorable impact of basiliximab induction therapy on early acute rejection rate. The impact on long-term outcome must be addressed in further randomized controlled trials.

title: XXXX , Mycophenolate Mofetil, and Low-Dose @entity1 With or  Without Interleukin-2 Receptor Antibody Induction Therapy: A  Retrospective Cohort Analysis.

answer: @entity4


abstract: In the adult @entity0 , nerve fibres do not regrow into the spinal cord after a dorsal root lesion. The elongation of dorsal root nerve fibres into the spinal cord of neonatal @entity1 was examined: L4 and L5 dorsal roots were crushed in @entity1 pups. After 3-6 months, the dorsal root-spinal cord junction was investigated morphologically in several long series of ultrathin cross-sections. In @entity1 which had been operated on at birth (0-2 days old), axons from the lesional roots could be followed into the CNS tissue of the spinal cord. In contrast to normal development, the usual short segment of CNS glia did not grow into the neonatally lesioned roots. Instead, the CNS-PNS border was located within the spinal cord. The nerve fibres, which were of normal diameter, had regrown across the PNS-CNS border and elongated further into the CNS environment of the spinal cord. In @entity1 operated on at the end of the first postnatal week or later, the largest dorsal root nerve fibres were only half the size of those in unoperated animals and reinnervation of the spinal cord had not occurred. An astrocyte-dominated CNS segment had developed in these roots. The impact of an early @entity2 on the development of certain glia cells and their importance in the outcome of spinal cord reinnervation are discussed.

title: Reinnervation of the XXXX spinal cord after neonatal dorsal root crush.

answer: @entity0


abstract: 1. We have begun to analyze neurotransmitter-activated conductances in @entity4 cells by measuring the response of single voltage-clamped adult @entity3 @entity7 cells to @entity1 ( @entity1 ). Here we describe 1) our method of identifying @entity7 cells in vitro after their dissociation from @entity5 , and 2) the response of these cells to @entity1 in the tight-seal whole cell configuration of the patch-clamp method (cf. 41) after 1-4 days of primary cell culture. 2. Ganglion cell somata were backfilled in situ by injections of horseradish peroxidase (HRP) into the optic nerve. After dissociation of the retinas containing these cells, HRP reaction product was localized to cells that retained the size, shape, and an intracellular organelle characteristic of @entity7 cells in situ. These features enabled us thereafter to identify @entity7 cells in vitro without retrograde marker transport. 3. @entity1 (3-10 microM) elicited inward currents and substantial noise increases in almost all @entity7 cells at negative holding potentials. Reversal potential measurements in salines containing different @entity6 concentrations indicated that @entity1 produces a @entity6 -selective conductance increase in @entity7 cells. @entity0 (10 microM) reversibly inhibited @entity7 cell @entity1 responses. @entity2 (10 microM) alone elicited no responses in @entity7 cells. 4. Noise analysis of @entity1 -activated whole cell currents yielded elementary conductance estimates of 16 pS, with a slow time constant of 30 ms plus a faster component of 1-2 ms. No significant voltage dependence of these values was observed between -20 and -80 mV. 5. We have thus devised a means of identifying @entity7 cells dissociated from adult retinas, identified GABAA receptors (cf. 16) on these cells, and found that the responses mediated by these receptors resemble those found in other regions of central nervous system (CNS). These results are consistent with the notion that @entity1 may function as an inhibitory transmitter at synapses on @entity7 cells.

title: @entity1 -activated whole-cell currents in isolated XXXX cells.

answer: @entity4


abstract: 1. We have begun to analyze neurotransmitter-activated conductances in @entity4 cells by measuring the response of single voltage-clamped adult @entity3 @entity7 cells to @entity1 ( @entity1 ). Here we describe 1) our method of identifying @entity7 cells in vitro after their dissociation from @entity5 , and 2) the response of these cells to @entity1 in the tight-seal whole cell configuration of the patch-clamp method (cf. 41) after 1-4 days of primary cell culture. 2. Ganglion cell somata were backfilled in situ by injections of horseradish peroxidase (HRP) into the optic nerve. After dissociation of the retinas containing these cells, HRP reaction product was localized to cells that retained the size, shape, and an intracellular organelle characteristic of @entity7 cells in situ. These features enabled us thereafter to identify @entity7 cells in vitro without retrograde marker transport. 3. @entity1 (3-10 microM) elicited inward currents and substantial noise increases in almost all @entity7 cells at negative holding potentials. Reversal potential measurements in salines containing different @entity6 concentrations indicated that @entity1 produces a @entity6 -selective conductance increase in @entity7 cells. @entity0 (10 microM) reversibly inhibited @entity7 cell @entity1 responses. @entity2 (10 microM) alone elicited no responses in @entity7 cells. 4. Noise analysis of @entity1 -activated whole cell currents yielded elementary conductance estimates of 16 pS, with a slow time constant of 30 ms plus a faster component of 1-2 ms. No significant voltage dependence of these values was observed between -20 and -80 mV. 5. We have thus devised a means of identifying @entity7 cells dissociated from adult retinas, identified GABAA receptors (cf. 16) on these cells, and found that the responses mediated by these receptors resemble those found in other regions of central nervous system (CNS). These results are consistent with the notion that @entity1 may function as an inhibitory transmitter at synapses on @entity7 cells.

title: XXXX -activated whole-cell currents in isolated @entity4 cells.

answer: @entity1


abstract: PURPOSE: Computed tomography (CT) is the most appropriate imaging modality for the assessment of @entity2 at the emergency unit. The aim of this study was to determine the clinical outcome of the @entity0 presented first time with symptoms of @entity2 and low CRP values. METHODS: Two-hundred @entity0 , who presented with the symptoms of @entity2 and had CRP values under 150  mg/L, underwent abdominal CT examination on admission to Oulu University Hospital. The clinical parameters and radiological findings were compared in relation to clinical outcome both by means of univariate and multivariate analyses. RESULTS: Seventy-one (35.5  %) of the 200 @entity0 presented on admission with complicated @entity3 . CRP values between 100 and 150  mg/L predicted complicated disease, but the mean values of CRP between @entity1 , 89  mg/ @entity4 , and complicated disease, 101  mg/ @entity4 , did not differ significantly. Free intra-abdominal fluid in CT was the only independent risk factor of the need for interventional therapy and treatment in the intensive care unit. Longevity of the @entity0 and free fluid in CT predicted significantly prolonged hospitalization. Mortality was 1  % and older @entity0 were significantly affected. The recurrence rate of @entity2 was 24  % (43/177) in the whole group and 18  % (23/129) after uncomplicated @entity3 . CONCLUSIONS: Low CRP values do not reliably predict @entity1 in @entity0 presented first time at the emergency unit with @entity2 . We recommend that the need for abdominal CT is carefully evaluated according to the @entity0 's clinical status, always even when the CRP value is under 150  mg/L.

title: The role of low CRP values in the prediction of the development of XXXX .

answer: @entity2


abstract: PURPOSE: To evaluate whether the content of @entity3 in the corneal epithelium and @entity6 reflects seasonal fluctuations in parallel with environmental changes. METHODS: @entity5 , @entity2 , @entity1 , and @entity0 were examined, to cover a broad spectrum of overlapping habitats. @entity3 was determined by high-performance liquid chromatography. The thickness of the corneal epithelium was measured, and the number of cells was counted in the tissue sections. RESULTS: Three groups of @entity5 eyes were used, two of them collected during summer, the third group during winter. @entity7 content did not show seasonal variation in either the corneal epithelium or the @entity6 , whereas epithelial thickness and number of cells decreased significantly from summer to winter. In @entity2 , @entity7 content, thickness of the epithelium, and number of cells were lower in animals tended indoors compared with those tended outdoors, whereas @entity7 level in the @entity6 remained similar in both cases. The @entity1 showed significantly reduced @entity7 content in the corneal epithelium but not in the @entity6 in @entity4 . This procedure did not change epithelial thickness, but the number of cells was slightly increased. The mean epithelial thickness in @entity0 corneas successively decreased with increasing latitude and decreasing radiation exposure from the summer season in Oslo to the midnight sun, polar night, conditions in Troms  , 10 degrees far north, although the differences did not reach statistical significance. CONCLUSIONS: Ambient radiation is needed to sustain high @entity3 concentration in the corneal epithelium. Corneal epithelial thickness and number of cells are prone to seasonal fluctuations regulated by ambient radiation. In contrast, @entity7 content of the @entity6 is uninfluenced by environmental change. It is suggested that seasonal adaptation of @entity0 corneal epithelium in response to variation in ambient radiation may be nature's strategy for countering radiation damage to the eye.

title: Impact of the environment on the XXXX corneal epithelium.

answer: @entity0


abstract: BACKGROUND: Whether the choice of dialysis modality in @entity0 with @entity3 may impact mortality is undecided. No randomized controlled trial has properly addressed this issue. Propensity-matched observational studies could give important insight into the independent effect of peritoneal ( @entity5 ) opposed to haemodialysis (HD) on all-cause and cardiovascular mortality. METHODS: To correct for case-mix differences between @entity0 treated with @entity5 and HD, propensity-matched analyses were utilized in all @entity0 who initiated dialysis as first renal replacement therapy in Norway in the period 2005-2012. @entity5 @entity0 were matched in a 1:1 fashion with HD @entity0 , creating 692 pairs of @entity0 with comparable baseline variables. As-treated and intention-to treat analyses were undertaken to assess cardiovascular and all-cause mortality. Interaction analyses were used to assess differences in the relationship between @entity4 and mortality, between strata of age, gender and prevalent @entity1 . RESULTS: In the as-treated analyses, @entity4 did not impact 2-year ( @entity5 vs. HD: HR 0.87, 95  % CI 0.67-1.12) or 5-year all-cause mortality (HR 0.95, 95  % CI 0.77-1.17). In @entity0 younger than 65  years, @entity5 was superior compared to HD with regard to both 2-year (HR 0.39, 95  % CI 0.19-0.81), and 5-year all-cause mortality (HR 0.49, 95  % CI 0.27-0.89). @entity2 was also lower in the younger @entity0 treated with @entity5 (5-year HR 0.38, 95  % CI 0.15-0.96). @entity5 was not associated with impaired prognosis in any of the prespecified subgroups compared to HD. The results were similar in the as-treated and intention-to-treat analyses. CONCLUSION: Survival in @entity5 was not inferior to HD in any subgroup of @entity0 even after five years of follow-up. In @entity0 below 65  years, @entity5 yielded superior survival rates compared to HD. Increased use of @entity5 as @entity4 in @entity3 @entity0 could be encouraged.

title: Impact of XXXX on mortality: a propensity-matched study.

answer: @entity4


abstract: OBJECTIVE: Extensive research exists on breaking bad news by clinicians. This study examines perspectives of @entity0 and those accompanying them at diagnosis-giving of subsequently sharing news of @entity1 with adult family/friends, and views of healthcare professionals, to inform development of a supportive intervention. METHODS: Qualitative interviews with 20 @entity0 , 17 accompanying @entity0 ; focus groups and interviews with 27 healthcare professionals from four Thoracic Oncology Units. Intervention development workshops with 24 healthcare professionals and six service users with experience of sharing a @entity2 diagnosis. Framework thematic analysis. RESULTS: @entity0 and accompanying @entity0 shared news of @entity1 whilst coming to terms with the diagnosis. They recalled general support from healthcare professionals but not support with sharing bad news. Six elements were identified providing a framework for a potential intervention: 1- @entity0 to be told, 2-information to be shared, 3-timing of sharing, 4-responsibility for sharing, 5-methods of telling others and 6-reactions of those told. CONCLUSION: This study identifies the challenge of sharing bad news and a potential framework to guide delivery of a supportive intervention tailored to individual needs of @entity0 . PRACTICE IMPLICATIONS: The identified framework could extend the portfolio of guidance on communication in @entity2 and potentially in other life-limiting conditions.

title: Sharing news of a XXXX diagnosis with adult family members and friends: a qualitative study to inform a supportive intervention.

answer: @entity1