abstract: BACKGROUND: It is usually assumed that @entity2 is associated with both the physical workload and the psychosocial work environment, as well as with personal and lifestyle factors. This study aims to ascertain the prevalence of @entity2 in @entity0 with varying or different occupational exposures, and to explore the associations between @entity2 and the occupational and personal factors. METHODS: A questionnaire on physical, psychosocial and individual factors was answered by 1591 @entity0 in five occupational groups with contrasting occupational exposures (teachers, anaesthetic, theatre, and assistant nurses, and sonographers). The outcome measure was @entity2 (in a new model based on frequency and intensity of complaints the preceding year) from the neck, shoulders, hands, lower back and feet. RESULTS: Neck @entity1 was equally frequent among teachers, assistant nurses and sonographers, and less frequent in anaesthetic and theatre nurses. The sonographers experienced the highest prevalence of @entity1 , while the assistant nurses were the most affected in the wrists and hands, lower back, and feet. The teachers reported the highest scores in most of the psychosocial dimensions. The theatre nurses scored highest in strenuous work postures and movements (mechanical exposure index, MEI), and the assistant nurses in physical activity and lifting (physical exposure index, PHYI). Multivariable models in the total population showed that both the physical workload and the psychosocial work environment were associated with @entity1 in all body regions, though different factors affected different regions. @entity1 in the neck, shoulders, hands and lower back was strongly associated with a high MEI and high job demands, while @entity1 in the feet was associated with a high PHYI and a high BMI. A young age was associated with @entity1 in the neck, and an older age was associated with @entity1 in the hands and feet. Lack of time for personal recovery was associated with @entity1 in the shoulders and lower back. CONCLUSIONS: The occupational groups were affected differently and need different protective measures. For the teachers, the psychosocial work environment should be improved. The surgical staff and sonographers require measures to mitigate lifting and constrained postures.

title: Cross-sectional associations between occupational factors and @entity2 in XXXX teachers, nurses and sonographers.

answer: @entity0


abstract: @entity2 serotype O157:H7 has been epidemiologically linked to outbreaks of @entity3 associated with fast-food restaurants and nursing homes. Sporadic cases now exceed those associated with outbreaks. The incidence of the organism in @entity0 with common @entity1 syndromes and in asymptomatic @entity0 is unknown. Routine serotyping of @entity2 isolates is impractical for most clinical microbiology laboratories. We developed a screening plate by utilizing @entity4 fermentation as a biochemical marker to identify organisms for serotyping. A total of 2,552 stool samples were screened. In 106 (4.1%), @entity4 -negative @entity2 were identified. Of these, two were serotype O157:H7, and both produced a Vero cell toxin. One @entity0 had @entity3 and the other a mild, febrile, self-limited @entity1 with no other bacterial pathogen identified. This plate provides an easy, effective method of screening for @entity4 -negative @entity2 , a process facilitating the selection of organisms for serotyping and one that may help clarify this organism's role in @entity0 disease.

title: Results of a screening method used in a 12-month stool survey for XXXX O157:H7.

answer: @entity2


abstract: Cytologic diagnosis of @entity7 can be very challenging. We report fine needle aspiration cytology (FNAC) findings of a benign @entity7 . The cytologic features are characterized by hypercellularity and the presence of numerous atypical dispersed cells with epithelioid morphology and intact cytoplasm. The nuclei showed stippled chromatin, irregular nuclear membrane, and prominent eosinophilic nucleoli. No @entity2 or mitoses were seen. The presence of naked nuclei, and extensive intranuclear cytoplasmic inclusions were identified and raised the possibility of @entity7 . Immunohistochemically, the atypical cells showed strong positivity for myosin heavy chain, @entity6 , and @entity5 , while the epithelial cells reacted with @entity3 receptors. This immunophenotypic pattern supports the myoepithelial origin of the atypical cell proliferation and favors the diagnosis of benign @entity7 . However, biopsy was recommended to exclude @entity1 . Histologically, the @entity1 showed prominent myoepithelial cells with significant atypia, intranuclear cytoplasmic inclusions, and dense cytoplasm. No evidence of @entity1 was identified. In conclusion, we report a case of @entity7 with a significant cytological atypia that may result in confusion with @entity0 . The presence of intranuclear cytoplasmic inclusions, naked nuclei, and expression of myoepithelial markers should provide clues to the right diagnosis and benign nature of this lesion. Cytopathologists should be familiarized with this entity to avoid a misdiagnosis of @entity4 .

title: Fine-needle aspiration biopsy of XXXX : a potential false positive pitfall and presence of intranuclear cytoplasmic inclusions.

answer: @entity0


abstract: Thirty-six cases of late onset @entity2 in @entity0 with filtering @entity3 are presented. Onset of @entity2 ranged from 4 months to 60 years after @entity3 formation. Possible contributing factors could be identified only in a minority of @entity0 . Aqueous, vitreous or both were cultured in all cases. Eighty-three percent of eyes were culture positive. Streptococci were the most frequent causative organisms, isolated from 57% of culture positive eyes. Twenty-three percent of eyes grew @entity4 . Only two cases were caused by staphylococci. In general, the visual outcome was poor, probably primarily due to the virulence of the infecting organisms. Endophthalmitis remains a risk even many years after creation of a filtering @entity3 . The microbiologic spectrum in this clinical setting is considerably different from that of recent @entity1 . Based on the bacteriology and clinical course of the @entity0 presented, recommendations for management are discussed.

title: Late onset XXXX associated with filtering @entity3 .

answer: @entity2


abstract: Thirty-six cases of late onset @entity2 in @entity0 with filtering @entity3 are presented. Onset of @entity2 ranged from 4 months to 60 years after @entity3 formation. Possible contributing factors could be identified only in a minority of @entity0 . Aqueous, vitreous or both were cultured in all cases. Eighty-three percent of eyes were culture positive. Streptococci were the most frequent causative organisms, isolated from 57% of culture positive eyes. Twenty-three percent of eyes grew @entity4 . Only two cases were caused by staphylococci. In general, the visual outcome was poor, probably primarily due to the virulence of the infecting organisms. Endophthalmitis remains a risk even many years after creation of a filtering @entity3 . The microbiologic spectrum in this clinical setting is considerably different from that of recent @entity1 . Based on the bacteriology and clinical course of the @entity0 presented, recommendations for management are discussed.

title: Late onset @entity2 associated with filtering XXXX .

answer: @entity3


abstract: OBJECTIVE: Our objective is to investigate the feasibility and validity of a new instrument to screen for determinants of poststroke @entity3 during the rehabilitation process. DESIGN AND SETTING: This prospective cohort study was conducted within the @entity1 department of a rehabilitation center. @entity0 : The @entity0 in the study were postacute adult @entity1 @entity0 . The Detection List Fatigue (DLF) was administered 2 weeks after the start of the rehabilitation program and again 6 weeks later. MAIN OUTCOME MEASURES: To determine the construct validity, the Hospital Anxiety and @entity2 Scale, the Checklist Individual Strength subscale @entity3 , and the Fatigue Severity Scale-7-item version were administered. A @entity3 rating scale was used to measure the @entity0 ' @entity3 experience. Frequency analyses of the number of @entity0 reporting poststroke @entity3 according to the DLF were performed. RESULTS: One hundred seven @entity0 (mean age 60 years) without severe communication difficulties were included in the study. The DLF was easy to understand and quick to administer. The DLF showed good internal consistency (Cronbach's alpha: .79 and .87), high convergent validity (rs   =   .85 and rs   =   .79), and good divergent validity (rs   =   .31 and rs   =   .45). The majority of the @entity0 (88.4%-90.2%) experienced at least 2 poststroke @entity3 (PSF) determinants, of which "sleeping problem" was most frequently reported. CONCLUSIONS: The DLF is a feasible and valid instrument for the screening of PSF determinants throughout the rehabilitation process in @entity1 @entity0 . Future studies should investigate whether the use of the list in determining a treatment plan prevents the development of PSF.

title: XXXX ; Feasibility and Validation of an Instrument for the Screening of Poststroke Fatigue throughout the Rehabilitation Process.

answer: @entity3


abstract: UNASSIGNED: @entity1 survivors often experience poor post-treatment musculoskeletal health. This study examined the feasibility of combined aerobic and resistant training ( @entity6 ) for improving strength, skeletal health and balance. @entity1 survivors (n  =  24) were identified by convenience sampling in Los Angeles County with 11 survivors consenting to 13  weeks of @entity6 . Pre- and post-intervention assessments of @entity2 ( @entity2 ), strength, flexibility and biomarker analysis were performed. Paired t-test analysis suggested increases in lower and upper body strength. The average T-score for @entity2 at the femoral neck improved from -1.46 to -1.36 and whole body @entity2 improved from -1.65 to -1.55. From baseline to follow-up, @entity0 also displayed decreases in sway velocity on the eyes open (7%) and eyes closed (27%) conditions. Improvement in lower body strength was associated with increases in lean body mass (LBM) (r  =  0.721) and an inverse association was observed between sway velocity and LBM (r  =  0.838). Age and time since last treatment were related with biomarkers of anabolic growth ( @entity4 , @entity5 ) and bone (DPD, BAP). In summary, observed physiological changes were consistent with functional improvements, suggesting that isometric and dynamic exercise prescription may reduce the risk for falls and fall-related @entity3 among survivors.

title: Training-related improvements in musculoskeletal health and balance: a 13-week pilot study of female XXXX survivors.

answer: @entity1


abstract: PURPOSE: We once reported blast-induced @entity0 (bTBI) in confined space. Here, bTBI was studied again on @entity4 in the open air using 3.0 kg @entity5 . METHODS: The @entity4 were placed at 2, 4, 6 and 8 m far from explosion center. @entity5 ( @entity5 ) was used as the source of the blast wave and the pressure at each distance was recorded. The systemic physiology, electroencephalogram, serum level of @entity6 , and @entity7 ( @entity7 ) were determined pre and post the exposure. Neuroanatomy and neuropathology were observed 4 h after the exposure. RESULTS: Simple blast waveforms were recorded with parameters of 702.8 kPa-0.442 ms, 148.4 kPa-2.503 ms, 73.9 kPa-3.233 ms, and 41.9 kPa-5.898 ms at 2, 4, 6 and 8 m respectively. Encephalic blast overpressure was on the first time recorded in the literature by us at 104.2 kPa-0.60 ms at 2 m, where mortality and burn rate were 44% and 44%. Gross examination showed that bTBI was mainly manifested as congestive expansion of blood vessels and @entity2 , which had a total incidence of 25% and 19% in 36 @entity4 . Microscopical observation found that the main pathohistological changes were enlarged perivascular space (21/36, 58%), small @entity3 (9/36, 25%), @entity1 and congestion (8/36, 22%), and less @entity2 (2/36, 6%). After explosion, serum levels of @entity6 and @entity7 were elevated, and EEG changed into slow frequency with declined amplitude. The results indicated that severity and incidence of bTBI is related to the intensity of blast overpressure. CONCLUSION: Blast wave can pass through the skull to directly injure brain tissue.

title: An open air research study of blast-induced XXXX to @entity4 .

answer: @entity0


abstract: PURPOSE: We once reported blast-induced @entity0 (bTBI) in confined space. Here, bTBI was studied again on @entity4 in the open air using 3.0 kg @entity5 . METHODS: The @entity4 were placed at 2, 4, 6 and 8 m far from explosion center. @entity5 ( @entity5 ) was used as the source of the blast wave and the pressure at each distance was recorded. The systemic physiology, electroencephalogram, serum level of @entity6 , and @entity7 ( @entity7 ) were determined pre and post the exposure. Neuroanatomy and neuropathology were observed 4 h after the exposure. RESULTS: Simple blast waveforms were recorded with parameters of 702.8 kPa-0.442 ms, 148.4 kPa-2.503 ms, 73.9 kPa-3.233 ms, and 41.9 kPa-5.898 ms at 2, 4, 6 and 8 m respectively. Encephalic blast overpressure was on the first time recorded in the literature by us at 104.2 kPa-0.60 ms at 2 m, where mortality and burn rate were 44% and 44%. Gross examination showed that bTBI was mainly manifested as congestive expansion of blood vessels and @entity2 , which had a total incidence of 25% and 19% in 36 @entity4 . Microscopical observation found that the main pathohistological changes were enlarged perivascular space (21/36, 58%), small @entity3 (9/36, 25%), @entity1 and congestion (8/36, 22%), and less @entity2 (2/36, 6%). After explosion, serum levels of @entity6 and @entity7 were elevated, and EEG changed into slow frequency with declined amplitude. The results indicated that severity and incidence of bTBI is related to the intensity of blast overpressure. CONCLUSION: Blast wave can pass through the skull to directly injure brain tissue.

title: An open air research study of blast-induced @entity0 to XXXX .

answer: @entity4


abstract: BACKGROUND: @entity4 in dermatology consist of intentionally self-inflicted @entity3 that vary in morphology and distribution and occur on surfaces readily accessible to the @entity0 's hands. They tend to be a chronic condition that waxes and wanes according to the circumstances of the @entity0 's life. @entity0 management poses a particular challenge to the clinician and the prognosis is considered poor. The aetiopathogenesis of @entity4 in dermatology is not completely understood. We present a case in which we suggested the occurrence of factitious behaviour during a dissociative state, and we briefly describe our diagnostic and therapeutic approach. @entity0 AND METHODS: A 48-year-old unemployed @entity0 was referred to our department of psychiatry by her dermatologist for suspected @entity4 . The @entity0 was diagnosed with @entity1 and had been hospitalized repeatedly for confirmed @entity1 . The onset of the disease was related to marital discord with her spouse. Numerous @entity3 had appeared on her face, arms, legs, neck and back. These lesions resulted in multiple hospital admissions and in amputation of her left leg. The condition had worsened considerably after her separation from her husband. During the initial conversation, the @entity0 was unable to provide a clear history of the disease. She denied any knowledge of the circumstances in which these @entity3 appeared, and she did not admit self-infliction. Her mood was depressed and her speech was slow. We suspected that our @entity0 was herself causing her @entity3 while in a dissociative state. Several arguments militate in favour of our hypothesis, particularly her history of childhood maltreatment and the association of traumatic life events with simultaneous deterioration of the skin. The explanation of the dissociative mechanism helped us to strengthen the therapeutic relationship. Within a few days, we noted a slow regression of the lesions, but the @entity0 was still unable to explain how the lesions had occurred. DISCUSSION: The pathophysiology of @entity4 in dermatology is poorly understood. It has strong ties with other @entity2 , and according to several authors, @entity3 occur in dissociative states, after which @entity0 do not remember how the skin change started. Management of this disease is challenging. An improved understanding of its mechanisms may enhance the prognosis for this particular group of @entity0 .

title: [ XXXX in dermatology: Value of the dissociative state concept].

answer: @entity4


abstract: INTRODUCTION: The American Academy of Pediatrics recommends operating on @entity3 between the ages of 6-12 months. Since most births in developed countries are conducted in a hospital, parents are likely to be well informed and counseled about the @entity3 . However, significant numbers of births in developing countries are still conducted at home, with illiteracy, poverty and ignorance often leading to late presentation at the hospital. Reported @entity3 -repair complication rates are higher in adults compared with those having surgery in childhood. The present study's objective was to evaluate the factors affecting surgical outcome in @entity3 @entity0 undergoing tubularized and tubularized incised plate urethroplasty (TIPU) in adulthood compared with childhood. MATERIALS AND METHODS: A prospective study of 60 adult @entity0 >16 years, and 60 pediatric @entity0 <5 years who underwent TIPU for @entity3 between May 2008 and May 2012. @entity0 were operated on by a single surgeon, under similar circumstances, and were pre-operatively examined to assess meatal location, chordee, and torsion; they were also examined intra-operatively for quality of spongiosum and urethral plate width. The outcomes were assessed by @entity0 /parents for satisfaction regarding cosmesis, urinary stream and complications. RESULTS: The age of the @entity0 varied from 16 to 27 years, with a mean of 20.8 years in adults, and 6 months to 5 years, with a mean of 2.1 years, in @entity0 . The type of @entity3 , degree of curvature, quality of spongiosum and urethral plate width were comparable in both groups, but complication rates were higher in adults (16.7%) than in the pediatric (6.7%) group (Figure  1A-D). @entity2 responded well to dilatation, but fistulae required revision surgery and had a cure rate of 100%. The median follow-up was 37 months in adults, and 39 months in @entity0 . DISCUSSION: The higher complication rates in adults may be due to more frequent erections; increased susceptibility to @entity1 along with relatively reduced vascularity lead to poor wound healing and increased complication rates. The limitation of the study was the small number of @entity0 with mid and proximal @entity3 having lesser incidences in comparison with @entity3 . Adequate number of @entity0 in these subgroups could have further strengthened the statistical correlation. Secondly, there was no objective criterion like uroflowmetry to assess urinary stream. CONCLUSIONS: Complication rates were higher in adults undergoing TIPU compared with pediatric @entity0 , which was also statistically significant in @entity3 . The important factors in surgical outcome were: severity of @entity3 , degree of curvature, quality of spongiosum, and urethral plate width.

title: Comparison of variables affecting the surgical outcomes of tubularized incised plate urethroplasty in adult and pediatric XXXX .

answer: @entity3


abstract: UNASSIGNED: We compared the performance of several prediction techniques for @entity0 prognosis, based on AU-ROC performance (Area Under ROC) for different prognosis periods. The analyzed dataset contained 1,981 @entity1 and from an initial 25 variables, the 11 most common clinical predictors were retained. We compared eight models from a wide spectrum of predictive models, namely; Generalized Linear Model (GLM), GLM-Net, Partial Least Square (PLS), Support Vector Machines (SVM), Random Forests (RF), Neural Networks, k-Nearest Neighbors (k-NN) and Boosted Trees. In order to compare these models, paired t-test was applied on the model performance differences obtained from data resampling. Random Forests, Boosted Trees, Partial Least Square and GLMNet have superior overall performance, however they are only slightly higher than the other models. The comparative analysis also allowed us to define a relative variable importance as the average of variable importance from the different models. Two sets of variables are identified from this analysis. The first includes number of positive lymph nodes, @entity2 size, @entity2 grade and @entity3 receptor, all has an important influence on model predictability. The second set incudes variables related to histological parameters and treatment types. The short term vs long term contribution of the clinical variables are also analyzed from the comparative models. From the various @entity2 treatment plans, the combination of Chemo/Radio therapy leads to the largest impact on @entity2 prognosis.

title: Model Comparison for XXXX Prognosis Based on Clinical Data.

answer: @entity0


abstract: INTRODUCTION: Image-guided interstitial (IRT) brachytherapy (BRT) is an effective treatment option as part of a multimodal approach to the treatment of isolated @entity1 . In this study, we report our results of computed tomography-guided IRT high-dose-rate (HDR) BRT in the local treatment of inoperable primary and secondary intrathoracic @entity3 . METHODS: Between 1997 and 2007, 55 @entity0 underwent a total of 68 interventional procedures for a total of 60 lung lesions. The median @entity3 volume was 160 cm   (range, 24-583 cm  ). Thirty-seven @entity0 were @entity0 and 18 were @entity0 , with a median age of 64 years (range, 31-93 years). The IRT-HDR-BRT delivered a median dose of 25.0 Gy (range, 10.0-32.0 Gy) in twice-daily fractions of 4.0 to 15.0 Gy in 27 @entity0 and 10.0 Gy (range, 7.0-32.0 Gy) in once-daily fractions of 4.0 to 20.0 Gy in 28 @entity0 . RESULTS: The median follow-up was 14 months (range, 1-49 months). The overall survival rate was 63% at 1 year, 26% at 2 years, and 7% at 3 years. The local control rate for @entity2 was 93%, 82%, and 82% and for primary @entity3 86%, 79%, and 73% at 1, 2, and 3 years, respectively. Pneumothoraces occurred in 11.7% of interventional procedures, necessitating postprocedural drainage in one (1.8%) @entity0 . CONCLUSIONS: In @entity0 with inoperable intrathoracic @entity3 , computed tomography-guided IRT-HDR-BRT is a safe and effective alternative to other locally ablative techniques.

title: Computed tomography-guided interstitial high-dose-rate brachytherapy in the local treatment of primary and secondary intrathoracic XXXX .

answer: @entity3


abstract: Rapid bedside determination of cerebral blood pressure autoregulation (AR) may improve clinical utility. We tested the hypothesis that cerebral Hb oxygenation (HbDiff) and cerebral Hb volume (HbTotal) measured by near-infrared spectroscopy (NIRS) would correlate with cerebral blood flow (CBF) after single dose @entity2 (PE). @entity3 @entity0 requiring artificial ventilation and arterial lines were eligible. During rapid blood pressure rise induced by i.v. PE bolus, /\HbDiff and /\HbTotal were calculated by subtracting values at baseline (normotension) from values at peak blood pressure elevation ( @entity1 ). With the aid of NIRS and bolus injection of @entity4 , relative measures of CBF, called blood flow index (BFI), were determined during normotension and during @entity1 . BFI during @entity1 was expressed as percentage from BFI during normotension (BFI%). Autoregulation indices (ARIs) were calculated by dividing BFI%, /\HbDiff, and /\HbTotal by the concomitant change in blood pressure. In 24 @entity0 (11 newborns and 13 @entity0 ), significant correlations between BFI% and /\HbDiff (or /\HbTotal) were found. In addition, the associations between Hb-based ARI and BFI%-based ARI were significant with correlation coefficients of 0.73 (or 0.72). Rapid determination of dynamic AR with the aid of cerebral Hb signals and PE bolus seems to be reliable.

title: Rapid assessment of cerebral autoregulation by near-infrared spectroscopy and a single dose of XXXX .

answer: @entity2


abstract: Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage in pre-neoplastic lesions and hotspots for chromosomal rearrangements in various @entity1 . Common fragile site instability was attributed to the fact that they contain sequences prone to form secondary structures that may impair replication fork movement, possibly leading to fork collapse resulting in DNA breaks. Here we show, in contrast to this view, that the fragility of @entity2 --the most active common fragile site in @entity0 lymphocytes--does not rely on fork slowing or stalling but on a paucity of initiation events. Indeed, in lymphoblastoid cells, but not in fibroblasts, initiation events are excluded from a @entity2 core extending approximately 700 kilobases, which forces forks coming from flanking regions to cover long distances in order to complete replication. We also show that origins of the flanking regions fire in mid-S phase, leaving the site incompletely replicated upon fork slowing. Notably, @entity2 instability is specific to cells showing this particular initiation pattern. The fact that both origin setting and replication timing are highly plastic in @entity0 cells explains the tissue specificity of common fragile site instability we observed. Thus, we propose that common fragile sites correspond to the latest initiation-poor regions to complete replication in a given cell type. For historical reasons, common fragile sites have been essentially mapped in lymphocytes. Therefore, common fragile site contribution to chromosomal rearrangements in @entity1 should be reassessed after mapping fragile sites in the cell type from which each @entity1 originates.

title: Cell-type-specific replication initiation programs set fragility of the XXXX fragile site.

answer: @entity2


abstract: OBJECTIVES: The aim of the first @entity2 ( @entity2 ) protocol was to study the clinical significance of an augmented @entity3 induction chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation (ASCT) and to examine the prognostic significance of stem cell contamination rates in newly diagnosed @entity0 with @entity2 . @entity0 AND METHODS: Forty-one newly diagnosed @entity0 below 66 yr were enrolled and given three series of an augmented @entity3 regimen. Responders underwent stem cell mobilization with a fourth course of @entity3 , stem cell harvest and ASCT. Stem cell purging was optional in the protocol and followed the routine of each participating centre. The number of @entity1 cells in the reinfused autografts was estimated by flow cytometry or quantitative PCR. RESULTS: Induction therapy led to complete remission (CR) in 11 of 41 @entity0 (27%), partial remission (PR) in 20 of 41 @entity0 (49%) and no response in nine @entity0 (22%), whereas one @entity0 was not evaluable. Twenty-seven of the 31 responders underwent ASCT and 24 achieved or maintained a CR. The overall and failure-free 4-yr survival on intention-to-treat basis were 51% and 15%, respectively. Among the transplanted @entity0 , a significantly increased failure-free (P<0.03) and overall survival (P=0.03) was noted among @entity0 transplanted in CR compared with PR, respectively. By contrast, reinfusion of highly variable numbers of @entity1 cells with the autografts (range 0.71-80 x 10(6) @entity1 cells), did not affect outcome. CONCLUSION: In @entity2 , an important strategy to improve the outcome will be to intensify the induction chemotherapy.

title: Primary treatment with autologous stem cell transplantation in XXXX : outcome related to remission pretransplant.

answer: @entity2


abstract: The efficacy and @entity2 of combination chemotherapy with @entity6 + @entity10 were evaluated in @entity0 with locally advanced or recurrent @entity1 . A total of 71 @entity0 with @entity1 were enrolled into this trial, and 66 @entity0 were considered eligible. The @entity0 were administered @entity6 at 60 mg/m2 followed by @entity10 based on area under the curve of 6, both by intravenous infusion, every 3 weeks, with the treatment repeated for 1 to 6 cycles depending on the goal of the therapy. The response was evaluated based on the Response Evaluation Criteria in @entity1 criteria. @entity2 to chemotherapy was evaluated according to the National @entity1 Institute Common @entity2 Criteria. Of the 66 eligible @entity0 , 62 had locally @entity1 with no history of previous treatment, whereas 4 @entity0 had recurrent @entity1 . A total 149 cycles of chemotherapy were administered, with a median of 2.3 cycles (range, 1-6) per @entity0 . The overall clinical response rate was 63.7% (44/66, 95% confidence interval, 52.1-75.3). In the neoadjuvant chemotherapy setting, the overall clinical response rate was 69.3% (43/62; 43/62, 95% confidence interval, 57.8-80.8), and the response rates in @entity0 with @entity5 and @entity7 were 69.7% (23/33, 95% confidence interval, 54.0-85.4) and 68.9% (20/29, 95% confidence interval, 52.1-85.7), respectively. On the other hand, in @entity0 with recurrent @entity1 , the overall response rate was 25.0% (1/4, 95% confidence interval, -17.4 to 67.4). Nonhematological @entity2 were mainly grade 1 or 2. @entity9 was encountered mostly in the form of @entity8 and @entity4 . Combination chemotherapy with @entity6 + @entity10 is a safe and well-tolerated treatment for @entity0 with @entity1 and is effective against not only @entity5 , but also @entity3 .

title: Phase II study of combination chemotherapy with @entity6 and XXXX for locally advanced or recurrent @entity1 .

answer: @entity10


abstract: The efficacy and @entity2 of combination chemotherapy with @entity6 + @entity10 were evaluated in @entity0 with locally advanced or recurrent @entity1 . A total of 71 @entity0 with @entity1 were enrolled into this trial, and 66 @entity0 were considered eligible. The @entity0 were administered @entity6 at 60 mg/m2 followed by @entity10 based on area under the curve of 6, both by intravenous infusion, every 3 weeks, with the treatment repeated for 1 to 6 cycles depending on the goal of the therapy. The response was evaluated based on the Response Evaluation Criteria in @entity1 criteria. @entity2 to chemotherapy was evaluated according to the National @entity1 Institute Common @entity2 Criteria. Of the 66 eligible @entity0 , 62 had locally @entity1 with no history of previous treatment, whereas 4 @entity0 had recurrent @entity1 . A total 149 cycles of chemotherapy were administered, with a median of 2.3 cycles (range, 1-6) per @entity0 . The overall clinical response rate was 63.7% (44/66, 95% confidence interval, 52.1-75.3). In the neoadjuvant chemotherapy setting, the overall clinical response rate was 69.3% (43/62; 43/62, 95% confidence interval, 57.8-80.8), and the response rates in @entity0 with @entity5 and @entity7 were 69.7% (23/33, 95% confidence interval, 54.0-85.4) and 68.9% (20/29, 95% confidence interval, 52.1-85.7), respectively. On the other hand, in @entity0 with recurrent @entity1 , the overall response rate was 25.0% (1/4, 95% confidence interval, -17.4 to 67.4). Nonhematological @entity2 were mainly grade 1 or 2. @entity9 was encountered mostly in the form of @entity8 and @entity4 . Combination chemotherapy with @entity6 + @entity10 is a safe and well-tolerated treatment for @entity0 with @entity1 and is effective against not only @entity5 , but also @entity3 .

title: Phase II study of combination chemotherapy with @entity6 and @entity10 for locally advanced or recurrent XXXX .

answer: @entity1


abstract: The efficacy and @entity2 of combination chemotherapy with @entity6 + @entity10 were evaluated in @entity0 with locally advanced or recurrent @entity1 . A total of 71 @entity0 with @entity1 were enrolled into this trial, and 66 @entity0 were considered eligible. The @entity0 were administered @entity6 at 60 mg/m2 followed by @entity10 based on area under the curve of 6, both by intravenous infusion, every 3 weeks, with the treatment repeated for 1 to 6 cycles depending on the goal of the therapy. The response was evaluated based on the Response Evaluation Criteria in @entity1 criteria. @entity2 to chemotherapy was evaluated according to the National @entity1 Institute Common @entity2 Criteria. Of the 66 eligible @entity0 , 62 had locally @entity1 with no history of previous treatment, whereas 4 @entity0 had recurrent @entity1 . A total 149 cycles of chemotherapy were administered, with a median of 2.3 cycles (range, 1-6) per @entity0 . The overall clinical response rate was 63.7% (44/66, 95% confidence interval, 52.1-75.3). In the neoadjuvant chemotherapy setting, the overall clinical response rate was 69.3% (43/62; 43/62, 95% confidence interval, 57.8-80.8), and the response rates in @entity0 with @entity5 and @entity7 were 69.7% (23/33, 95% confidence interval, 54.0-85.4) and 68.9% (20/29, 95% confidence interval, 52.1-85.7), respectively. On the other hand, in @entity0 with recurrent @entity1 , the overall response rate was 25.0% (1/4, 95% confidence interval, -17.4 to 67.4). Nonhematological @entity2 were mainly grade 1 or 2. @entity9 was encountered mostly in the form of @entity8 and @entity4 . Combination chemotherapy with @entity6 + @entity10 is a safe and well-tolerated treatment for @entity0 with @entity1 and is effective against not only @entity5 , but also @entity3 .

title: Phase II study of combination chemotherapy with XXXX and @entity10 for locally advanced or recurrent @entity1 .

answer: @entity6


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity3 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity1 pulse therapy combined with @entity7 with @entity1 alone in the treatment of Candida fingernail @entity3 . METHODS: Ninety @entity0 with moderate to severe Candida fingernail @entity3 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity1 pulse therapy for 2 months and applied @entity7 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity1 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity0 were analysed (73 @entity0 and 12 @entity0 , mean +/- SD age 44.2 +/- 12.9 years). @entity0 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity3 was 11 months. Paronychial involvement was evident in 71 @entity0 . @entity2 was isolated in 85 cases, @entity4 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity0 in group 1 and in 25 (60%) of 42 @entity0 in group 2. At the 9-month visit, a global cure was seen in 40 @entity0 (93%) in group 1 and in 34 @entity0 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity5 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity7 and oral @entity1 , which interfere with different steps of @entity6 synthesis, exhibited substantial synergy. Compared with oral @entity1 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity7 and two pulses of @entity1 is at least as safe and effective as three pulses of @entity1 , with a lower cost per @entity0 . In our opinion, the addition of @entity7 to oral @entity1 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity3 .

title: A randomized trial of XXXX 5% solution nail lacquer in association with @entity1 pulse therapy compared with @entity1 alone in the treatment of Candida fingernail @entity3 .

answer: @entity7


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity3 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity1 pulse therapy combined with @entity7 with @entity1 alone in the treatment of Candida fingernail @entity3 . METHODS: Ninety @entity0 with moderate to severe Candida fingernail @entity3 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity1 pulse therapy for 2 months and applied @entity7 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity1 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity0 were analysed (73 @entity0 and 12 @entity0 , mean +/- SD age 44.2 +/- 12.9 years). @entity0 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity3 was 11 months. Paronychial involvement was evident in 71 @entity0 . @entity2 was isolated in 85 cases, @entity4 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity0 in group 1 and in 25 (60%) of 42 @entity0 in group 2. At the 9-month visit, a global cure was seen in 40 @entity0 (93%) in group 1 and in 34 @entity0 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity5 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity7 and oral @entity1 , which interfere with different steps of @entity6 synthesis, exhibited substantial synergy. Compared with oral @entity1 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity7 and two pulses of @entity1 is at least as safe and effective as three pulses of @entity1 , with a lower cost per @entity0 . In our opinion, the addition of @entity7 to oral @entity1 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity3 .

title: A randomized trial of @entity7 5% solution nail lacquer in association with @entity1 pulse therapy compared with @entity1 alone in the treatment of Candida fingernail XXXX .

answer: @entity3


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity3 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity1 pulse therapy combined with @entity7 with @entity1 alone in the treatment of Candida fingernail @entity3 . METHODS: Ninety @entity0 with moderate to severe Candida fingernail @entity3 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity1 pulse therapy for 2 months and applied @entity7 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity1 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity0 were analysed (73 @entity0 and 12 @entity0 , mean +/- SD age 44.2 +/- 12.9 years). @entity0 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity3 was 11 months. Paronychial involvement was evident in 71 @entity0 . @entity2 was isolated in 85 cases, @entity4 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity0 in group 1 and in 25 (60%) of 42 @entity0 in group 2. At the 9-month visit, a global cure was seen in 40 @entity0 (93%) in group 1 and in 34 @entity0 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity5 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity7 and oral @entity1 , which interfere with different steps of @entity6 synthesis, exhibited substantial synergy. Compared with oral @entity1 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity7 and two pulses of @entity1 is at least as safe and effective as three pulses of @entity1 , with a lower cost per @entity0 . In our opinion, the addition of @entity7 to oral @entity1 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity3 .

title: A randomized trial of @entity7 5% solution nail lacquer in association with XXXX pulse therapy compared with @entity1 alone in the treatment of Candida fingernail @entity3 .

answer: @entity1


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity3 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity1 pulse therapy combined with @entity7 with @entity1 alone in the treatment of Candida fingernail @entity3 . METHODS: Ninety @entity0 with moderate to severe Candida fingernail @entity3 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity1 pulse therapy for 2 months and applied @entity7 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity1 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity0 were analysed (73 @entity0 and 12 @entity0 , mean +/- SD age 44.2 +/- 12.9 years). @entity0 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity3 was 11 months. Paronychial involvement was evident in 71 @entity0 . @entity2 was isolated in 85 cases, @entity4 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity0 in group 1 and in 25 (60%) of 42 @entity0 in group 2. At the 9-month visit, a global cure was seen in 40 @entity0 (93%) in group 1 and in 34 @entity0 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity5 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity7 and oral @entity1 , which interfere with different steps of @entity6 synthesis, exhibited substantial synergy. Compared with oral @entity1 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity7 and two pulses of @entity1 is at least as safe and effective as three pulses of @entity1 , with a lower cost per @entity0 . In our opinion, the addition of @entity7 to oral @entity1 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity3 .

title: A randomized trial of @entity7 5% solution nail lacquer in association with @entity1 pulse therapy compared with XXXX alone in the treatment of Candida fingernail @entity3 .

answer: @entity1


abstract: INTRODUCTION: We describe a case of early and persistent reverse end-diastolic flow in the middle cerebral artery in a fetus with severe @entity7 . These features are associated with a rare @entity2 known as @entity5 . CASE PRESENTATION: A 28-year-old Caucasian @entity0 was referred to our high-risk obstetric unit at 24 weeks' gestation for @entity9 detected during a routine ultrasound examination. During her hospitalization we performed medical investigations, including a fetal paracentesis, to detect the etiology of @entity9 . The cause of @entity9 (then considered non-immune or idiopathic) was not evident, but a subsequent ultrasound examination at 27 weeks' gestation showed a reverse end-diastolic flow in the middle cerebral artery without any other @entity8 . A cesarean section was performed at 28 weeks' gestation because of the compromised fetal condition. An autopsy revealed a rare @entity6 of intrahepatic bile ducts known as @entity5 . CONCLUSION: Persistent reverse flow in the middle cerebral artery should be considered a marker of adverse pregnancy outcome. We recommend careful ultrasound monitoring in the presence of this ultrasonographic sign to exclude any other cause of @entity4 . To better understand the nature of these ultrasonographic signs, additional reports are deemed necessary. In fact in our case, as confirmed by histopathological examination, the fetal condition was extremely compromised due to failure of the fetal liver. @entity5 altered the liver structures causing @entity10 and probably portal @entity3 . These two conditions therefore explain the severe @entity1 that compromised the fetal situation.

title: Reverse end-diastolic flow in a fetus with a rare XXXX : a case report.

answer: @entity2


abstract: BACKGROUND: Navarre, in Northern Spain, is an area with moderate exposure to olive and ash tree pollen. OBJECTIVE: To assess the relevance of ash as a cause of @entity3 in our region. METHODS: The study sample comprised 85 @entity0 from Navarre with clinical symptoms of @entity3 . Specific immunoglobulin E (sIgE) was determined to Fra e 1, Ole e 1, and a mixture of @entity1 - and @entity2 -terminal domains of Ole e 9 (Ole e 9 NC) (ADVIA-Centaur). At the same time, the presence of sIgE to other pollen allergens was studied. Prick tests were performed with ash pollen (n=33) and olive pollen (n=85) and the symptomatic period was recorded (n=85). As a control group, we studied the serum of 98 @entity0 with olive pollen allergy, intense exposure to olive pollen, and no exposure to ash. RESULTS: Sensitization to Oleaceae was detected in 24/85 @entity0 in the study group (28.2%). In this group, the mean (SD) level of IgE to Fra e 1 was 8.5 (10) kU(A)/L and to Ole e 16.07 (7.88) kU(A)/L (P < .001). In the control group, these figures were 103.64 (132.19) kU(A)/L and 86.43 (118.5) kU(A)/L (P < .001), respectively. In all @entity0 with positive sIgE to Fra e 1, IgE to Ole e 1 was also detected (concordance index, kappa = 1), both in the study group and in the control group. @entity0 who were sensitized to Fra e 1 did not present a longer symptomatic period and their symptoms did not have an earlier onset. CONCLUSION: We did not find evidence of clinically relevant sensitization to ash in Navarre.

title: Oleaceae-induced XXXX in an area with exposure to olive and ash trees.

answer: @entity3


abstract: Diets higher in protein content result in increased satiety and energy expenditure. In the short term, gelatin showed stronger hunger suppression and less subsequent energy intake compared with other proteins. The present study investigated whether a supra-sustained gelatin-milk protein (GMP) diet promotes @entity0 compared with a sustained milk protein ( @entity4 ) diet and a supra-sustained milk protein (SSMP) diet during an 8-week diet period. A total of seventy-two healthy subjects (31  2 (sd 4  8)  kg/m2; 43 (sd 10) years) followed one of the three diets in a subject-specific amount: @entity4 , SSMP or @entity3 diet. During weeks 1-4, energy intake was 100  % of individual energy requirement: 10, 40 and 50  % of energy (En  %) as protein, fat and @entity2 , respectively ( @entity4 diet), and 20, 30 and 50  En  % as protein, fat and @entity2 , respectively (SSMP diet or GMP diet). During weeks 5-8, energy intake was 33  % of individual energy requirement: 30, 35 and 35  En  % as protein, fat and @entity2 , respectively ( @entity4 diet), and 60, 5 and 35  En  % as protein, fat and @entity2 , respectively (SSMP diet or GMP diet). Thus, absolute protein intake was kept constant throughout per subject. Significant decreases in BMI (P  <  0  0001) were similar between the GMP (  -  1  7 (sd 0  5)  kg/m2) and the @entity4 (  -  2  1 (sd 0  8)  kg/m2) and SSMP (  -  1  6 (sd 0  5)  kg/m2) diets. Decreases in @entity1 ( @entity1 ), fat mass (FM) and FM  %, and increases in @entity1  % were similar between the GMP and both control diets. Changes in RQ differed (P  <  0  05) between the GMP (  -  0  01 (sd 0  06)) and SSMP (  -  0  04 (sd 0  04)) diets. Changes in HDL concentrations differed (P  <  0  05) between the GMP (  -  0  21 (sd 0  18)  mmol/l) and the @entity4 and SSMP diets (  -  0  08 (sd 0  18)  mmol/l and -  0  09 (sd 0  26)  mmol/l, respectively). In conclusion, a gelatin-milk protein diet does not induce more beneficial effects during an 8-week weight-loss period compared with a @entity4 or SSMP diet.

title: Effects of a supra-sustained gelatin-milk protein diet compared with (supra-)sustained milk protein diets on body- XXXX .

answer: @entity0


abstract: Cordyceps sinensis (CS) is a traditional Chinese medicine and health food used to support many organ systems. It is commercially produced by cultivation in a liquid medium or on a solid (grain/ @entity3 ) phase. We tested the effects of hot water extracts of liquid-phase and solid-phase commercially grown CS on its ability to influence proliferation (using Alamar blue, an oxidation/reduction indicator), migration (serial-wounded monolayer photomicroscopy), invasion through collagen gel (fluorometric assay) and @entity7 -induced apoptosis (active caspase-3 colorimetric assay) of @entity0 @entity4 HT29 cells. An in vivo study used a @entity1 @entity6 model ( @entity7 20 mg/kg and 4 h restraint with oral administration). The CS extract stimulated cell proliferation threefold when added at 10  g/ml (P < 0  01). Cell migration increased by 69 % and invasion by 17 % when CS was added at 5 mg/ml (P < 0  01). The results also showed that 93 % of the pro-proliferative activity was soluble in @entity5 , whereas pro-migratory activity was divided (61:49) into both @entity5 -soluble and @entity5 -insoluble sub-fractions. @entity7 -induced apoptosis was not affected by the presence of CS. CS reduced the amount of @entity6 by 63 % when administered orally at 20 mg/ml (P < 0  01), the results being similar to using the potent cytoprotective agent epidermal growth factor at 25  g/ml (83 % reduction). We conclude that both methods of cultivated CS possess biological activity when analysed using a variety of gut models of @entity2 . Functional foods, such as CS, could provide a novel approach for the prevention and treatment of @entity2 .

title: Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and @entity1 XXXX .

answer: @entity6


abstract: Cordyceps sinensis (CS) is a traditional Chinese medicine and health food used to support many organ systems. It is commercially produced by cultivation in a liquid medium or on a solid (grain/ @entity3 ) phase. We tested the effects of hot water extracts of liquid-phase and solid-phase commercially grown CS on its ability to influence proliferation (using Alamar blue, an oxidation/reduction indicator), migration (serial-wounded monolayer photomicroscopy), invasion through collagen gel (fluorometric assay) and @entity7 -induced apoptosis (active caspase-3 colorimetric assay) of @entity0 @entity4 HT29 cells. An in vivo study used a @entity1 @entity6 model ( @entity7 20 mg/kg and 4 h restraint with oral administration). The CS extract stimulated cell proliferation threefold when added at 10  g/ml (P < 0  01). Cell migration increased by 69 % and invasion by 17 % when CS was added at 5 mg/ml (P < 0  01). The results also showed that 93 % of the pro-proliferative activity was soluble in @entity5 , whereas pro-migratory activity was divided (61:49) into both @entity5 -soluble and @entity5 -insoluble sub-fractions. @entity7 -induced apoptosis was not affected by the presence of CS. CS reduced the amount of @entity6 by 63 % when administered orally at 20 mg/ml (P < 0  01), the results being similar to using the potent cytoprotective agent epidermal growth factor at 25  g/ml (83 % reduction). We conclude that both methods of cultivated CS possess biological activity when analysed using a variety of gut models of @entity2 . Functional foods, such as CS, could provide a novel approach for the prevention and treatment of @entity2 .

title: Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and XXXX @entity6 .

answer: @entity1


abstract: South Asia is considered to have a high prevalence of @entity1 ( @entity1 ) against @entity0 . Therefore the World Health Organisation has called for context-specific information about @entity1 from different regions. A scoping review of published and gray literature over the last 35 years was conducted using Arksey and O'Malley's framework. Reported prevalence of @entity1 in @entity2 Lanka ranged from 20-72%, with recent reports of rates ranging from 25- 35%. Most research about @entity1 has been conducted in a few provinces and is based on the experience of legally married @entity0 . Individual, family, and societal risk factors for @entity1 have been studied, but their complex relationships have not been comprehensively investigated. Health consequences of @entity1 have been reported, with particular attention to physical health, but @entity0 are likely to underreport sexual violence. @entity0 seek support mainly from informal networks, with only a few visiting agencies to obtain help. Little research has focused on health sector responses to @entity1 and their effectiveness. More research is needed on how to challenge gendered perceptions about @entity1 . Researchers should capture the experience of @entity0 in dating/cohabiting relationships and @entity0 in vulnerable sectors (post-conflict areas and rural areas), and assess how to effectively provide services to them. A critical evaluation of existing services and programmes is also needed to advance evidence informed programme and policy changes in @entity2 Lanka.

title: Intimate partner violence in XXXX Lanka: a scoping review.

answer: @entity2


abstract: AIM. An exposition is given of the data on the incidence of @entity2 in Navarra in the five year period 1988-92, by age and sex groups. MATERIAL AND METHODS. The collection of data of the 1988-92 five year period was carried out in an active form in the information sources. The procedures for collection, control of duplicates and processing of previous years were maintained. Both the indicators of quality and the calculations of the different rates were obtained following the recommendations proposed by the International Agency of @entity2 Research (IARC). RESULTS. Between 1988 and 1992 11,608 incident cases of @entity2 were registered in Navarra. 58% were found in @entity1 . Excluding other @entity4 , the rate adjusted to the world population was of 274.1 per 100,000 for @entity1 and 182.9 per 100,000 for @entity1 . The localisations where the adjusted rates were higher for @entity1 excluding other @entity4 were lung, prostate and bladder, and for @entity1 the localisations were breast, uterine corpus and colon. Amongst @entity1 an increasing tendency was noted of @entity3 , and of @entity0 amongst @entity1 . The decrease of @entity2 in both sexes was notable. CONCLUSIONS. Navarra is situated at an intermediate level of incidence with respect to other European countries. In relation to other registers was of note the high rate of @entity2 in @entity1 and the low rate of cervical @entity2 in @entity1 .

title: [Incidence of XXXX in Navarra. 1988-92].

answer: @entity2


abstract: In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed @entity2 ( @entity2 ). Although @entity3 ( @entity3 ) antibody levels of the cohort fluctuated, the antibody levels of 93% of the @entity0 with @entity2 were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor @entity1 progression during the preclinical stage of @entity2 development, facilitating early @entity2 detection. We reviewed the clinical records of the 171 @entity0 with @entity2 in the prospective study to assess the efficacy of early @entity2 detection by serologic screening and clinical examination. Of the 171 @entity0 , 51 had Stage I @entity1 (44 were among the 73 @entity0 detected by clinical examination and 7 were among the 98 @entity0 presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 @entity0 detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I @entity1 . The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I @entity1 among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of @entity2 can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect @entity1 before the symptoms develop.

title: Detection of XXXX by serologic screening and clinical examination.

answer: @entity1


abstract: INTRODUCTION: This is a prospective descriptive study of intervention without aleatory assignation, carried out in the Chantrea Health Centre. Its aim is to determine the characteristics of the smokers who are taking part in two interventions by the Smokers' Aid Program (Programa de Ayuda al Fumador-PAF), and to evaluate the factors that influence the latter's success. MATERIAL AND METHODS: The characteristics of 100 smokers were analyzed. They were offered one of the two PAF interventions: Minimal Intervention 1 (MN1): they are given a support brochure in the first consultations, contacted by telephone after one month and called to consultation after 6 months to measure CO. Minimal Intervention 2 (MN2): the smoker makes 5 consultations of support in giving up smoking (+ or - @entity1 patches) with the doctor, nurse or social worker indiscriminately. The factors that were influential in abandoning the habit with 65 subjects were evaluated. RESULTS: 60% of the subjects were male with an average age of 41 (DE 29). 29% showed a pathology related to @entity0 , with no relation found between this and the success of the interventions. Those who chose MN2 (38%) had started @entity0 consumption at an earlier age and were more dependent on @entity1 . Of the 65 smokers who completed the program, 37% continued not to smoke after 6 months. Those who managed to give up smoking were of a greater average age, had spent more years smoking and belonged above all to the MN1 intervention. DISCUSSION: Notable successes are achieved if the actions are carried out by the First Aid Team. We find no significant differences between the characteristics of those who give up smoking and those who do not. Not even a serious pathology, related to @entity0 , is predictive of success. The smoker's dependence on @entity1 must be taken into account in the intervention.

title: [Giving up the XXXX habit through the application of the Smoker's Aid Program in the Chantrea Health Centre].

answer: @entity0


abstract: PURPOSE: A major complication associated with the use of resilient denture liners (RDLs) is a change in @entity1 over time. In vivo studies on the deterioration of RDLs over time are needed. We aimed to investigate the influence of @entity0 characteristics on the @entity1 of acrylic-based RDLs (ARDLs) embedded in complete maxillary dentures. We hypothesized that 1 month after application of the ARDLs, the @entity1 would be influenced by age, saliva condition, occlusal force, smoking, drinking, denture wearing during sleeping, denture cleanser usage, and denture type. METHODS: Thirty complete maxillary denture wearers were recruited after obtaining informed consent. One investigator measured the Shore D @entity1 of the commercially available ARDLs, Soften (SFT), @entity2 Soft (FDS), and Bio Liner (BIO) using a Vesmeter(  ). The salivary flow rates and pH values and the occlusal force were measured for all @entity0 before initiation of the study. T-tests and Pearson's correlation coefficients were used for the statistical analyses. A p-value of <0.05 was considered statistically significant. RESULTS: Smoking, wearing dentures while sleeping, use of denture cleansers, and denture type were associated with an increase in the @entity1 of the RDLs. The resting saliva pH only influenced the @entity1 of the SFT ARDLs. CONCLUSIONS: Smoking, denture wearing while sleeping, denture cleanser usage, denture type, and resting saliva pH are important predictors of the deterioration of ARDLs over time.

title: The influence of XXXX characteristics on acrylic-based resilient denture liners embedded in maxillary complete dentures.

answer: @entity0


abstract: BACKGROUND Ventriculoperitoneal shunting is an effective treatment for @entity3 . @entity1 is a common complication. @entity4 as an implicated organism is rare. In this report, we describe a @entity0 with cryptococcal @entity1 . CASE REPORT A 52-year-old male with normal pressure @entity3 , status post implantation of VPS one year prior to the presentation; who was admitted with a fever, lethargy and confusion for three days. He was treated empirically with intravenous @entity9 and @entity6 for @entity1 . The CSF analysis from both the lumbar puncture and the VPS was significant for a low white blood count, low @entity2 and high protein. Other work-up including India ink and cryptococcal antigen was unrevealing. He remained febrile despite antibiotic treatment for 5 days. The CSF from the shunt was sent for analysis again and it demonstrated similar results from the prior study, but the culture was now positive for @entity4 . The @entity0 was started on oral @entity8 and intravenous liposomal @entity7 . The VPS was removed and an externalized ventricular catheter was placed. The @entity0 showed rapid resolution of the symptoms. CONCLUSIONS To date, there was a total of nine reported cases of cryptococcal @entity1 upon review of the literature. Our presenting case and the literature review highlight the difficulties in making an accurate diagnosis of cryptococcal @entity1 . There were case reports of false negative cryptococcal antigen tests with culture proven @entity5 . The CSF culture from the shunt remains a mainstay for identifying cryptococcal @entity1 . @entity1 are rare and early diagnosis and treatment is essential for @entity0 management which involves shunt replacement with concomitant administration of intravenous antifungal medication. High clinical suspicion is crucial and shunt culture preferably from the valve is recommended.

title: Cryptococcal Infection of the Ventriculoperitoneal Shunt in an Immunocompetent XXXX .

answer: @entity0


abstract: BACKGROUND _ AIMS: This study investigated the efficacy of gastric electrical stimulation for the treatment of @entity5 unresponsive to standard medical therapy. METHODS: Thirty-three @entity0 with chronic @entity5 (17 @entity1 and 16 idiopathic) received continuous high-frequency/low-energy gastric electrical stimulation via electrodes in the muscle wall of the antrum connected to a neurostimulator in an abdominal wall pocket. After implantation, @entity0 were randomized in a double-blind crossover design to stimulation ON or OFF for 1-month periods. The blind was then broken, and all @entity0 were programmed to stimulation ON and evaluated at 6 and 12 months. Outcome measures were @entity4 frequency, preference for ON or OFF, upper gastrointestinal tract symptoms, quality of life, gastric emptying, and adverse events. RESULTS: In the double-blind portion of the study, self-reported @entity4 frequency was significantly reduced in the ON vs. OFF period (P < 0.05) and this symptomatic improvement was consistent with the significant @entity0 preference (P < 0.05) for the ON vs. OFF period determined before breaking the blind. In the unblinded portion of the study, @entity4 frequency decreased significantly (P < 0.05) at 6 and 12 months. Scores for symptom severity and quality of life significantly improved (P < 0.05) at 6 and 12 months, whereas gastric emptying was only modestly accelerated. Five @entity0 had their gastric electrical stimulation system explanted or revised because of @entity2 . CONCLUSIONS: High-frequency/low-energy gastric electrical stimulation significantly decreased @entity4 frequency and @entity3 and improved quality of life in @entity0 with severe @entity5 .

title: Gastric electrical stimulation for medically refractory XXXX .

answer: @entity5


abstract: @entity1 perception is believed to be associated with @entity2 . @entity4 patients with antisocial features are more impaired in @entity5 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity6 ( @entity6 ) using stringent criteria. We recruited 30 @entity0 with dual diagnoses of @entity6 and @entity4 , 30 @entity0 with @entity4 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity5 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity5 , and control for the effect of other @entity3 on @entity5 . Correlational analyses were conducted to examine the association between @entity5 and @entity2 . @entity0 with dual diagnoses performed worst in @entity5 among the three groups. The group differences in @entity5 remained significant, even after other @entity3 were controlled for. Severity of @entity2 was correlated with impairment in perceiving negative-valenced @entity5 in @entity0 with dual diagnoses. Our findings support the presence of @entity1 and its association with @entity2 in @entity4 @entity0 with comorbid @entity6 .

title: @entity1 in XXXX @entity0 with comorbid @entity6 .

answer: @entity4


abstract: @entity1 perception is believed to be associated with @entity2 . @entity4 patients with antisocial features are more impaired in @entity5 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity6 ( @entity6 ) using stringent criteria. We recruited 30 @entity0 with dual diagnoses of @entity6 and @entity4 , 30 @entity0 with @entity4 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity5 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity5 , and control for the effect of other @entity3 on @entity5 . Correlational analyses were conducted to examine the association between @entity5 and @entity2 . @entity0 with dual diagnoses performed worst in @entity5 among the three groups. The group differences in @entity5 remained significant, even after other @entity3 were controlled for. Severity of @entity2 was correlated with impairment in perceiving negative-valenced @entity5 in @entity0 with dual diagnoses. Our findings support the presence of @entity1 and its association with @entity2 in @entity4 @entity0 with comorbid @entity6 .

title: @entity1 in @entity4 @entity0 with comorbid XXXX .

answer: @entity6


abstract: @entity1 perception is believed to be associated with @entity2 . @entity4 patients with antisocial features are more impaired in @entity5 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity6 ( @entity6 ) using stringent criteria. We recruited 30 @entity0 with dual diagnoses of @entity6 and @entity4 , 30 @entity0 with @entity4 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity5 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity5 , and control for the effect of other @entity3 on @entity5 . Correlational analyses were conducted to examine the association between @entity5 and @entity2 . @entity0 with dual diagnoses performed worst in @entity5 among the three groups. The group differences in @entity5 remained significant, even after other @entity3 were controlled for. Severity of @entity2 was correlated with impairment in perceiving negative-valenced @entity5 in @entity0 with dual diagnoses. Our findings support the presence of @entity1 and its association with @entity2 in @entity4 @entity0 with comorbid @entity6 .

title: XXXX in @entity4 @entity0 with comorbid @entity6 .

answer: @entity1


abstract: @entity1 perception is believed to be associated with @entity2 . @entity4 patients with antisocial features are more impaired in @entity5 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity6 ( @entity6 ) using stringent criteria. We recruited 30 @entity0 with dual diagnoses of @entity6 and @entity4 , 30 @entity0 with @entity4 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity5 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity5 , and control for the effect of other @entity3 on @entity5 . Correlational analyses were conducted to examine the association between @entity5 and @entity2 . @entity0 with dual diagnoses performed worst in @entity5 among the three groups. The group differences in @entity5 remained significant, even after other @entity3 were controlled for. Severity of @entity2 was correlated with impairment in perceiving negative-valenced @entity5 in @entity0 with dual diagnoses. Our findings support the presence of @entity1 and its association with @entity2 in @entity4 @entity0 with comorbid @entity6 .

title: @entity1 in @entity4 XXXX with comorbid @entity6 .

answer: @entity0


abstract: @entity2 ( @entity2 ) are environmental pollutants that, because of their persistence and biomagnification, raise concerns about the health consequences of long-term exposure. @entity4 mixtures induce @entity1 in rodents, but the mechanism of their promoting activity is not clear. Previous studies have shown that oxidative stress occurs after @entity4 administration, with the induction of lipid peroxidation and oxidative DNA damage, which may contribute to their promoting activity. In this study, we examined whether the oxidative stress-sensitive transcription factors NF-kappaB or @entity6 were activated by @entity2 in the liver. Male @entity0 were injected i.p. with @entity3 oil, @entity5 ( @entity5 , 30, 150, or 300 micromol/kg), @entity7 ( @entity7 , 30, 150, or 300 micromol/kg), or both @entity2 (each 30 or 150 micromol/kg). @entity0 were euthanized 2, 6, or 24 h, or 2, 6, and 10 d after the @entity4 injection. Electrophoretic mobility shift assays (EMSAs) were performed to determine NF-kappaB and @entity6 DNA binding activities. The highest NF-kappaB DNA binding activity was observed in @entity0 receiving higher doses of @entity5 (150 and 300 micromol/kg), with peak activation occurring 2 d after injection. @entity6 activation was not detected at any timepoint. Hepatocyte proliferation, as measured by the labeling index, was increased only in groups receiving the highest dose of @entity5 or the combination of two @entity2 (150 micromol/kg each) at day 2, and not by any other @entity4 treatment at any timepoint. These results show that @entity5 , but not @entity7 , can induce hepatocyte proliferation and hepatic NF-kappaB activation after a single dose.

title: Effect of a single dose of @entity2 on hepatic cell proliferation and the DNA binding activity of NF-kappaB and XXXX in @entity0 .

answer: @entity6


abstract: @entity2 ( @entity2 ) are environmental pollutants that, because of their persistence and biomagnification, raise concerns about the health consequences of long-term exposure. @entity4 mixtures induce @entity1 in rodents, but the mechanism of their promoting activity is not clear. Previous studies have shown that oxidative stress occurs after @entity4 administration, with the induction of lipid peroxidation and oxidative DNA damage, which may contribute to their promoting activity. In this study, we examined whether the oxidative stress-sensitive transcription factors NF-kappaB or @entity6 were activated by @entity2 in the liver. Male @entity0 were injected i.p. with @entity3 oil, @entity5 ( @entity5 , 30, 150, or 300 micromol/kg), @entity7 ( @entity7 , 30, 150, or 300 micromol/kg), or both @entity2 (each 30 or 150 micromol/kg). @entity0 were euthanized 2, 6, or 24 h, or 2, 6, and 10 d after the @entity4 injection. Electrophoretic mobility shift assays (EMSAs) were performed to determine NF-kappaB and @entity6 DNA binding activities. The highest NF-kappaB DNA binding activity was observed in @entity0 receiving higher doses of @entity5 (150 and 300 micromol/kg), with peak activation occurring 2 d after injection. @entity6 activation was not detected at any timepoint. Hepatocyte proliferation, as measured by the labeling index, was increased only in groups receiving the highest dose of @entity5 or the combination of two @entity2 (150 micromol/kg each) at day 2, and not by any other @entity4 treatment at any timepoint. These results show that @entity5 , but not @entity7 , can induce hepatocyte proliferation and hepatic NF-kappaB activation after a single dose.

title: Effect of a single dose of XXXX on hepatic cell proliferation and the DNA binding activity of NF-kappaB and @entity6 in @entity0 .

answer: @entity2


abstract: @entity2 ( @entity2 ) are environmental pollutants that, because of their persistence and biomagnification, raise concerns about the health consequences of long-term exposure. @entity4 mixtures induce @entity1 in rodents, but the mechanism of their promoting activity is not clear. Previous studies have shown that oxidative stress occurs after @entity4 administration, with the induction of lipid peroxidation and oxidative DNA damage, which may contribute to their promoting activity. In this study, we examined whether the oxidative stress-sensitive transcription factors NF-kappaB or @entity6 were activated by @entity2 in the liver. Male @entity0 were injected i.p. with @entity3 oil, @entity5 ( @entity5 , 30, 150, or 300 micromol/kg), @entity7 ( @entity7 , 30, 150, or 300 micromol/kg), or both @entity2 (each 30 or 150 micromol/kg). @entity0 were euthanized 2, 6, or 24 h, or 2, 6, and 10 d after the @entity4 injection. Electrophoretic mobility shift assays (EMSAs) were performed to determine NF-kappaB and @entity6 DNA binding activities. The highest NF-kappaB DNA binding activity was observed in @entity0 receiving higher doses of @entity5 (150 and 300 micromol/kg), with peak activation occurring 2 d after injection. @entity6 activation was not detected at any timepoint. Hepatocyte proliferation, as measured by the labeling index, was increased only in groups receiving the highest dose of @entity5 or the combination of two @entity2 (150 micromol/kg each) at day 2, and not by any other @entity4 treatment at any timepoint. These results show that @entity5 , but not @entity7 , can induce hepatocyte proliferation and hepatic NF-kappaB activation after a single dose.

title: Effect of a single dose of @entity2 on hepatic cell proliferation and the DNA binding activity of NF-kappaB and @entity6 in XXXX .

answer: @entity0


abstract: BACKGROUND: Close association between @entity2 ( @entity2 ) and @entity3 ( @entity3 ) has been demonstrated by several studies. Important gender differences exist in @entity2 @entity0 including a higher plasma @entity3 level in @entity0 . Therefore, it is imperative to evaluate the relationship between @entity2 and @entity3 separately in @entity0 and @entity0 . OBJECTIVE: This study examined possible gender-specific role of @entity3 in predicting procedure outcome in @entity2 @entity0 undergoing catheter ablation. METHOD: The study population included 568 consecutive @entity0 (age 62    10, male 73%, paroxysmal 25%, persistent 38%, and long-standing persistent @entity2 37%) undergoing @entity2 ablation, who had structurally normal heart and left ventricular ejection fraction >= 45%. Baseline @entity3 was measured in all. @entity0 were grouped into "normal" and "high" @entity3 based on gender-specific cut-off values (<50 and >= 50 pg/mL in males, <100 and >=  100 pg/mL in females). RESULT: Baseline @entity3 was significantly higher among @entity0 than @entity0 (126    112 versus 87    99, P = 0.009). At 12    6 month follow-up, 304 of 414 (73%) males and 98 of 154 (64%) females were @entity2 / @entity1 -free off antiarrhythmic drugs (log-rank P = 0.018). In multivariable analysis, @entity3 remained an independent predictor of @entity2 recurrence ( @entity3 >=  50: hazard ratio [HR] 2.54, P = 0.006) in males. No such association was observed among females ( @entity3 >=  100: HR 0.79, 95% CI 0.43-1.42; P = 0.426). CONCLUSION: Baseline @entity3 was found to be an independent predictor of @entity2 recurrence in male @entity0 undergoing ablation. This correlation between @entity3 and @entity2 recurrence was not observed in females. Thus, @entity3 plays a gender-specific prognostic role in @entity2 .

title: Baseline B-type natriuretic peptide: a gender-specific predictor of procedure-outcome in XXXX @entity0 undergoing catheter ablation.

answer: @entity2


abstract: BACKGROUND: Close association between @entity2 ( @entity2 ) and @entity3 ( @entity3 ) has been demonstrated by several studies. Important gender differences exist in @entity2 @entity0 including a higher plasma @entity3 level in @entity0 . Therefore, it is imperative to evaluate the relationship between @entity2 and @entity3 separately in @entity0 and @entity0 . OBJECTIVE: This study examined possible gender-specific role of @entity3 in predicting procedure outcome in @entity2 @entity0 undergoing catheter ablation. METHOD: The study population included 568 consecutive @entity0 (age 62    10, male 73%, paroxysmal 25%, persistent 38%, and long-standing persistent @entity2 37%) undergoing @entity2 ablation, who had structurally normal heart and left ventricular ejection fraction >= 45%. Baseline @entity3 was measured in all. @entity0 were grouped into "normal" and "high" @entity3 based on gender-specific cut-off values (<50 and >= 50 pg/mL in males, <100 and >=  100 pg/mL in females). RESULT: Baseline @entity3 was significantly higher among @entity0 than @entity0 (126    112 versus 87    99, P = 0.009). At 12    6 month follow-up, 304 of 414 (73%) males and 98 of 154 (64%) females were @entity2 / @entity1 -free off antiarrhythmic drugs (log-rank P = 0.018). In multivariable analysis, @entity3 remained an independent predictor of @entity2 recurrence ( @entity3 >=  50: hazard ratio [HR] 2.54, P = 0.006) in males. No such association was observed among females ( @entity3 >=  100: HR 0.79, 95% CI 0.43-1.42; P = 0.426). CONCLUSION: Baseline @entity3 was found to be an independent predictor of @entity2 recurrence in male @entity0 undergoing ablation. This correlation between @entity3 and @entity2 recurrence was not observed in females. Thus, @entity3 plays a gender-specific prognostic role in @entity2 .

title: Baseline B-type natriuretic peptide: a gender-specific predictor of procedure-outcome in @entity2 XXXX undergoing catheter ablation.

answer: @entity0


abstract: BACKGROUND: Approximately 30% of @entity0 undergoing @entity1 ( @entity1 ) for @entity3 ( @entity3 ) have clinical recurrence of @entity3 , and a great majority of these @entity0 have recovery of vein conduction. @entity2 can be associated with acute recovery of conduction to the pulmonary veins immediately after isolation. However, it is not known whether this is prognostic for permanent recovery of conduction or recurrence of @entity3 . METHODS: @entity0 with paroxysmal @entity3 underwent @entity1 , with administration of @entity2 after electrical isolation. Those with transient conduction recovery (TCR+) underwent no further ablation and were compared to those without (TCR-) for clinical @entity3 recurrence and conduction recovery at second procedure. RESULTS: Seventy-two consecutive @entity1 @entity0 were studied (mean age 56.7    9.2, 61 male). Twenty-five (35%) @entity0 had transient recovery of conduction with @entity2 . After 1 year, 18 @entity0 (25%) had symptomatic recurrence of @entity3 . In this group of 18 @entity0 , 6 were TCR+ at initial ablation (sensitivity 33%, NPV = 74%). In the remaining group of 54 @entity0 free from @entity3 recurrence, 35 @entity0 (65%) were TCR- at initial ablation (specificity 65%, @entity4 = 24%). All 18 @entity0 with recurrent @entity3 underwent repeat procedure and had at least 1 pulmonary vein with recurrent conduction. The initial @entity2 test correctly predicted 13 out of 36 (36%) veins, with positive predictive value 90% and negative predictive value 15%. CONCLUSIONS: @entity2 testing for TCR does not appear to predict recurrence of clinical @entity3 . TCR- veins remain susceptible to conduction recovery, as determined at the follow-up procedure.

title: Does @entity2 response predict clinical recurrence of @entity3 after XXXX ?

answer: @entity1


abstract: BACKGROUND: Approximately 30% of @entity0 undergoing @entity1 ( @entity1 ) for @entity3 ( @entity3 ) have clinical recurrence of @entity3 , and a great majority of these @entity0 have recovery of vein conduction. @entity2 can be associated with acute recovery of conduction to the pulmonary veins immediately after isolation. However, it is not known whether this is prognostic for permanent recovery of conduction or recurrence of @entity3 . METHODS: @entity0 with paroxysmal @entity3 underwent @entity1 , with administration of @entity2 after electrical isolation. Those with transient conduction recovery (TCR+) underwent no further ablation and were compared to those without (TCR-) for clinical @entity3 recurrence and conduction recovery at second procedure. RESULTS: Seventy-two consecutive @entity1 @entity0 were studied (mean age 56.7    9.2, 61 male). Twenty-five (35%) @entity0 had transient recovery of conduction with @entity2 . After 1 year, 18 @entity0 (25%) had symptomatic recurrence of @entity3 . In this group of 18 @entity0 , 6 were TCR+ at initial ablation (sensitivity 33%, NPV = 74%). In the remaining group of 54 @entity0 free from @entity3 recurrence, 35 @entity0 (65%) were TCR- at initial ablation (specificity 65%, @entity4 = 24%). All 18 @entity0 with recurrent @entity3 underwent repeat procedure and had at least 1 pulmonary vein with recurrent conduction. The initial @entity2 test correctly predicted 13 out of 36 (36%) veins, with positive predictive value 90% and negative predictive value 15%. CONCLUSIONS: @entity2 testing for TCR does not appear to predict recurrence of clinical @entity3 . TCR- veins remain susceptible to conduction recovery, as determined at the follow-up procedure.

title: Does @entity2 response predict clinical recurrence of XXXX after @entity1 ?

answer: @entity3


abstract: BACKGROUND: Approximately 30% of @entity0 undergoing @entity1 ( @entity1 ) for @entity3 ( @entity3 ) have clinical recurrence of @entity3 , and a great majority of these @entity0 have recovery of vein conduction. @entity2 can be associated with acute recovery of conduction to the pulmonary veins immediately after isolation. However, it is not known whether this is prognostic for permanent recovery of conduction or recurrence of @entity3 . METHODS: @entity0 with paroxysmal @entity3 underwent @entity1 , with administration of @entity2 after electrical isolation. Those with transient conduction recovery (TCR+) underwent no further ablation and were compared to those without (TCR-) for clinical @entity3 recurrence and conduction recovery at second procedure. RESULTS: Seventy-two consecutive @entity1 @entity0 were studied (mean age 56.7    9.2, 61 male). Twenty-five (35%) @entity0 had transient recovery of conduction with @entity2 . After 1 year, 18 @entity0 (25%) had symptomatic recurrence of @entity3 . In this group of 18 @entity0 , 6 were TCR+ at initial ablation (sensitivity 33%, NPV = 74%). In the remaining group of 54 @entity0 free from @entity3 recurrence, 35 @entity0 (65%) were TCR- at initial ablation (specificity 65%, @entity4 = 24%). All 18 @entity0 with recurrent @entity3 underwent repeat procedure and had at least 1 pulmonary vein with recurrent conduction. The initial @entity2 test correctly predicted 13 out of 36 (36%) veins, with positive predictive value 90% and negative predictive value 15%. CONCLUSIONS: @entity2 testing for TCR does not appear to predict recurrence of clinical @entity3 . TCR- veins remain susceptible to conduction recovery, as determined at the follow-up procedure.

title: Does XXXX response predict clinical recurrence of @entity3 after @entity1 ?

answer: @entity2


abstract: INTRODUCTION AND OBJECTIVE: Tinea @entity3 are due to @entity2 by dermatophytes. They are common in developing countries including Morocco. The objective of this study intended to describe the epidemiology, clinical and mycological profile of @entity3 in Avicenna military hospital of Marrakech. @entity0 AND METHODS: This is a retrospective study over an 8-year period (from 1st January 2006  to 31st December 2013). All @entity0 targeted through this study presented to the laboratory with the suspicion of @entity3 , they were under a detailed investigation with a careful mycological analysis; diagnosis of @entity3 was established as the direct examination and/or the sampling proved positive. RESULTS: Of the 334  @entity0 investigated, 216  had a TC with an overall prevalence of 64.67%. The average age was 6  years. The M/F sex ratio was 0.55. The isolated dermatophytes were @entity5 with 105  cases (63.26%), @entity4 violaceum in 44  cases (26.51%), T.  mentographytes in 8  cases (4.81%), M.  langeronii in 5  cases (3.01%), @entity4 in 3  cases (1.8%) and T.  schoenleinii in 1  case (0.61%). The contact with animals was found in 40% of cases and immunosupression in 3.47% of cases. We verify through our investigation that tineas predominate among school age @entity0 with a female predominance. The epidemiological profile of TC in our study is similar to that of other studies in Moroccan and Maghrebian countries investigations. CONCLUSION: The TC is relatively a mild @entity1 but can be confused with other dermatoses not easy to diagnose. For this reason, their treatment necessitates a mycological analysis.

title: [Tinea XXXX in the military hospital Avicenna (Morocco): Review of 8years (2006-2013)].

answer: @entity3


abstract: WHAT IS KNOWN AND OBJECTIVE: Regular blood transfusions in the management of @entity5 ( @entity5 ) often lead to @entity2 overload. The main objective of this study was to evaluate the impact of medication adherence on the effectiveness of @entity7 for the treatment of transfusional @entity2 overload in @entity0 with @entity5 . Secondary objectives were to describe treatment effectiveness and safety in daily clinical practice. METHODS: A longitudinal, retrospective, observational study was carried out in a university hospital. The inclusion criteria were age over 18 years, @entity5 diagnosis and treatment with @entity7 for transfusion-dependent @entity2 overload during the period of study (from January 2011 to April 2015). Treatment effectiveness was estimated by serum ferritin (SF), and adherence was measured by medication possession ratio (MPR). Clinically relevant analytical alterations during the treatment and reasons for treatment discontinuation were also assessed. RESULTS: Thirty-five @entity0 were included in the study. Median SF at baseline was 1636  g/L, and it decreased to 1399  g/L during follow-up. The median adherence rate was 92%, although only 54  8% of the @entity0 maintained @entity7 adherence >= 90% during the whole duration of treatment. Adherence rate was inversely correlated to SF (r = -0  288, P = 0  004). The median ( @entity6 , @entity4 ) duration of treatment was 11 (3  0, 37  8) months. The most common reasons for treatment discontinuation were @entity1 (35%) and @entity0 's @entity3 (25%). WHAT IS NEW AND CONCLUSION: @entity7 's effectiveness, measured by the decrease in SF, was significantly better in adherent @entity0 . The most frequent reason for treatment discontinuation was @entity1 . Developing strategies to improve @entity7 treatment adherence and monitoring renal function in those @entity0 should be key points in pharmaceutical care.

title: Impact of medication adherence on the effectiveness of @entity7 for the treatment of transfusional @entity2 overload in XXXX .

answer: @entity5


abstract: WHAT IS KNOWN AND OBJECTIVE: Regular blood transfusions in the management of @entity5 ( @entity5 ) often lead to @entity2 overload. The main objective of this study was to evaluate the impact of medication adherence on the effectiveness of @entity7 for the treatment of transfusional @entity2 overload in @entity0 with @entity5 . Secondary objectives were to describe treatment effectiveness and safety in daily clinical practice. METHODS: A longitudinal, retrospective, observational study was carried out in a university hospital. The inclusion criteria were age over 18 years, @entity5 diagnosis and treatment with @entity7 for transfusion-dependent @entity2 overload during the period of study (from January 2011 to April 2015). Treatment effectiveness was estimated by serum ferritin (SF), and adherence was measured by medication possession ratio (MPR). Clinically relevant analytical alterations during the treatment and reasons for treatment discontinuation were also assessed. RESULTS: Thirty-five @entity0 were included in the study. Median SF at baseline was 1636  g/L, and it decreased to 1399  g/L during follow-up. The median adherence rate was 92%, although only 54  8% of the @entity0 maintained @entity7 adherence >= 90% during the whole duration of treatment. Adherence rate was inversely correlated to SF (r = -0  288, P = 0  004). The median ( @entity6 , @entity4 ) duration of treatment was 11 (3  0, 37  8) months. The most common reasons for treatment discontinuation were @entity1 (35%) and @entity0 's @entity3 (25%). WHAT IS NEW AND CONCLUSION: @entity7 's effectiveness, measured by the decrease in SF, was significantly better in adherent @entity0 . The most frequent reason for treatment discontinuation was @entity1 . Developing strategies to improve @entity7 treatment adherence and monitoring renal function in those @entity0 should be key points in pharmaceutical care.

title: Impact of medication adherence on the effectiveness of XXXX for the treatment of transfusional @entity2 overload in @entity5 .

answer: @entity7


abstract: WHAT IS KNOWN AND OBJECTIVE: Regular blood transfusions in the management of @entity5 ( @entity5 ) often lead to @entity2 overload. The main objective of this study was to evaluate the impact of medication adherence on the effectiveness of @entity7 for the treatment of transfusional @entity2 overload in @entity0 with @entity5 . Secondary objectives were to describe treatment effectiveness and safety in daily clinical practice. METHODS: A longitudinal, retrospective, observational study was carried out in a university hospital. The inclusion criteria were age over 18 years, @entity5 diagnosis and treatment with @entity7 for transfusion-dependent @entity2 overload during the period of study (from January 2011 to April 2015). Treatment effectiveness was estimated by serum ferritin (SF), and adherence was measured by medication possession ratio (MPR). Clinically relevant analytical alterations during the treatment and reasons for treatment discontinuation were also assessed. RESULTS: Thirty-five @entity0 were included in the study. Median SF at baseline was 1636  g/L, and it decreased to 1399  g/L during follow-up. The median adherence rate was 92%, although only 54  8% of the @entity0 maintained @entity7 adherence >= 90% during the whole duration of treatment. Adherence rate was inversely correlated to SF (r = -0  288, P = 0  004). The median ( @entity6 , @entity4 ) duration of treatment was 11 (3  0, 37  8) months. The most common reasons for treatment discontinuation were @entity1 (35%) and @entity0 's @entity3 (25%). WHAT IS NEW AND CONCLUSION: @entity7 's effectiveness, measured by the decrease in SF, was significantly better in adherent @entity0 . The most frequent reason for treatment discontinuation was @entity1 . Developing strategies to improve @entity7 treatment adherence and monitoring renal function in those @entity0 should be key points in pharmaceutical care.

title: Impact of medication adherence on the effectiveness of @entity7 for the treatment of transfusional XXXX overload in @entity5 .

answer: @entity2


abstract: OBJECTIVE: To assess the effectiveness of inspiratory muscular training (IMT) on measures of strength, resistance, functional performance, and quality of life (QOL) for chronic @entity1 survivors. DESIGN: Double-blinded randomized controlled trial. SETTING: Research laboratory. @entity0 : Subjects (N=21) with @entity1 (11 @entity0 , 10 @entity0 ; @entity2 [ @entity2 ] <90% of predicted values) were randomly assigned to the experimental (n=11) and control groups (n=10); 18 @entity0 completed all testing and training. INTERVENTIONS: Interventions were based on home-based training, with resistance adjusted biweekly to 30% of @entity2 for the experimental group. The control group underwent the same protocol without the threshold resistance valve. Both groups received home training 30 minutes a day 5 times a week for 8 weeks. MAIN OUTCOME MEASURES: @entity2 , inspiratory muscular endurance (IME), functional performance, and QOL. RESULTS: There were significant between-group differences for the @entity2 and IME measures. Significant changes were observed for only the experimental group for @entity2 (67.8  14.6 at baseline to 102.2  26.0cm @entity3 at posttraining) and IME (31.8  19.3 to 49.2  21.1cm @entity3 ). No statistically significant differences were observed for measures of functional performance and QOL. CONCLUSIONS: Significant short-term effects of the IMT program for inspiratory strength and endurance were observed in chronic @entity1 survivors. These findings gave some indications that IMT may benefit @entity0 with @entity1 , and it is feasible to be included in rehabilitation interventions with this population.

title: Inspiratory muscular training in chronic XXXX survivors: a randomized controlled trial.

answer: @entity1


abstract: OBJECTIVES: Aims of this study were to investigate the effect of renal function on left ventricular (LV) reverse remodeling and long-term outcome after cardiac resynchronization therapy (CRT), and to explore the relation between LV reverse remodeling and changes in renal function at 6-month follow-up. BACKGROUND: @entity2 is highly prevalent in @entity3 @entity0 , including @entity0 eligible for CRT, and is associated with poor prognosis. METHODS: The study comprised 490 @entity0 undergoing CRT. Response to CRT was defined as a decrease in LV end-systolic volume >= 15% at 6-month follow-up. Primary end point during long-term follow-up was all-cause mortality. RESULTS: At baseline, mean estimated glomerular filtration rate (eGFR) was 70    28 ml/ @entity4 .73 m  . At 6-month follow-up, 263 @entity0 (54%) demonstrated response to CRT. Responders had an eGFR of 74    26 ml/ @entity4 .73 m   versus 64    28 ml/ @entity4 .73 m   in nonresponders (p < 0.001). During long-term follow-up, @entity0 with an eGFR <60 ml/ @entity4 .73 m   had higher mortality than @entity0 with an eGFR of 60 to 90 ml/ @entity4 .73 m   or an eGFR >90 ml/ @entity4 .73 m   (p < 0.001). Finally, responders to CRT had preservation of renal function (/\eGFR -0.6), whereas nonresponders had a slight worsening in renal function (/\eGFR -4.7, p < 0.05). CONCLUSIONS: @entity1 in CRT candidates is associated with nonresponse during 6-month follow-up. Additionally, @entity0 with @entity1 have worse long-term survival after CRT. Response to CRT results in preservation of renal function.

title: XXXX is associated with echocardiographic nonresponse and poor prognosis after cardiac resynchronization therapy.

answer: @entity1