abstract: We previously showed in a small group of donors that eosinophils from a subgroup of individuals responded equipotently to CC chemokine ligand ( @entity5 /eotaxin and @entity4 / @entity4 in assays of eosinophil shape change ( @entity4 / @entity4 -highly responsive (MHR) donors). In this study, we investigated the functional role of @entity4 in eosinophil responses in 73 donors. MHR donors, identified by their eosinophil shape change responses, represented approximately 19% of the donor pool. Eosinophils from these donors showed increased eosinophil @entity6 expression and also underwent @entity4 -mediated chemotaxis and up-regulation of @entity3 . All MHR donors gave a history of @entity1 . In a further study, we prospectively recruited 110 subjects, subdivided into nonatopics or atopics, and investigated expression of @entity6 and @entity7 on eosinophils, basophils, monocytes, and neutrophils. Eosinophil @entity6 expression was non-normally distributed in atopics, although higher @entity6 expression levels were not predictive of a diagnosis of @entity2 or @entity1 . We identified the @entity6 promoter and investigated its function. We found a minimal promoter within 177 bp of the transcription start site, and an upstream enhancer region that facilitated expression in leukocyte cell lines. Collectively, these data demonstrate that MHR individuals form an important subgroup that, when associated with a diagnosis of @entity0 , may require tailored therapy to modulate eosinophil recruitment. Identification of a functional @entity6 promoter will facilitate the study of possible genetic determinants underlying this potentially important clinical phenotype.

title: Variations in eosinophil chemokine responses: an investigation of @entity6 and @entity7 function, expression in XXXX , and identification of a functional @entity6 promoter.

answer: @entity2


abstract: UNASSIGNED: Selective mutism (SM) is a debilitating condition in which a @entity0 does not speak in social situations where speech is expected. The clinical conceptualization of SM has been debated historically, with evidence pointing partly to anxious and oppositional behavior profiles. Behavioral characteristics were examined in a clinical sample of 57 youth formally diagnosed with selective mutism. Parents rated @entity0 across internalizing and externalizing behaviors on the @entity0 Behavior Checklist. Eighteen highly rated items were subjected to exploratory and then confirmatory factor analysis. @entity2 and oppositional behavior factors were derived. The anxious behavior profile was associated with @entity2 , social problems, and @entity1 but not @entity3 . The oppositional behavior profile was associated with @entity1 , @entity3 , social problems, and inversely to @entity2 . Results are consistent with emerging research regarding subgroups of @entity0 with SM. Behavior profiles are discussed as well with respect to assessment and treatment implications. LEARNING OUTCOMES: Readers will learn about the nature of @entity0 with selective mutism as well as behaviors that differentiate anxious and oppositional behavior profiles. Items that comprise anxious and oppositional behavior profiles are presented. These item profiles may have ramifications for assessment and treatment.

title: XXXX and oppositional behavior profiles among youth with selective mutism.

answer: @entity2


abstract: OBJECTIVE: Using structural equation modeling, this study is one of the first efforts aimed at assessing influential factors causing gender differences in the association between health-related quality of life (HRQoL) and @entity1 . METHODS: A sample of 950 adults, from Tehran Lipid and @entity2 Study were recruited for this cross sectional study in 2005-2007. Health-related quality of life was assessed using the Iranian version of SF-36. @entity1 components (MetSCs) and physical and mental HRQoL were considered as continuous latent constructs explaining the variances of their observed components. Structural equation modeling was performed to examine the association between the constructs of MetSCs and the physical and mental HRQoL within the two gender groups. RESULTS: Based on the primary hypothesis, MetSCs and HRQoL were fitted in a model. The negative effect of MetSCs on HRQoL was found to be significant only in the physical domain and only in @entity0 . The proportion of all the cardio-metabolic risk factors as well as subscales of physical HRQoL that have been explained via the two constructs of MetSCs and HRQoL, respectively, were significantly higher in @entity0 . Physical activity in both @entity0 (b = 3.19, p<0.05) and @entity0 (b = 3.94, p<0.05), age (b = -3.28, p<0.05), education (b = 2.63, p<0.05) only in @entity0 and smoking (b = 2.28, p<0.05) just in @entity0 , directly affected physical HRQoL. Regarding the mental domain, physical activity (b = 3.37, p<0.05) and marital status (b = 3.44, p<0.05) in @entity0 and age (b = 2.01, p<0.05) in @entity0 were direct effective factors. Age and education in @entity0 as well as smoking in @entity0 indirectly affected physical HRQoL via MetSCs. CONCLUSION: Gender differences in the association between MetSCs and physical HRQoL could mostly be attributed to the different structures of both MetSCs and physical HRQoL constructs in @entity0 and @entity0 . Age and smoking are the most important socio-behavioral factors which could affect this gender-specific association in the mental domain.

title: Factors Affecting Gender Differences in the Association between Health-Related Quality of Life and @entity1 Components: Tehran Lipid and XXXX Study.

answer: @entity2


abstract: OBJECTIVE: Using structural equation modeling, this study is one of the first efforts aimed at assessing influential factors causing gender differences in the association between health-related quality of life (HRQoL) and @entity1 . METHODS: A sample of 950 adults, from Tehran Lipid and @entity2 Study were recruited for this cross sectional study in 2005-2007. Health-related quality of life was assessed using the Iranian version of SF-36. @entity1 components (MetSCs) and physical and mental HRQoL were considered as continuous latent constructs explaining the variances of their observed components. Structural equation modeling was performed to examine the association between the constructs of MetSCs and the physical and mental HRQoL within the two gender groups. RESULTS: Based on the primary hypothesis, MetSCs and HRQoL were fitted in a model. The negative effect of MetSCs on HRQoL was found to be significant only in the physical domain and only in @entity0 . The proportion of all the cardio-metabolic risk factors as well as subscales of physical HRQoL that have been explained via the two constructs of MetSCs and HRQoL, respectively, were significantly higher in @entity0 . Physical activity in both @entity0 (b = 3.19, p<0.05) and @entity0 (b = 3.94, p<0.05), age (b = -3.28, p<0.05), education (b = 2.63, p<0.05) only in @entity0 and smoking (b = 2.28, p<0.05) just in @entity0 , directly affected physical HRQoL. Regarding the mental domain, physical activity (b = 3.37, p<0.05) and marital status (b = 3.44, p<0.05) in @entity0 and age (b = 2.01, p<0.05) in @entity0 were direct effective factors. Age and education in @entity0 as well as smoking in @entity0 indirectly affected physical HRQoL via MetSCs. CONCLUSION: Gender differences in the association between MetSCs and physical HRQoL could mostly be attributed to the different structures of both MetSCs and physical HRQoL constructs in @entity0 and @entity0 . Age and smoking are the most important socio-behavioral factors which could affect this gender-specific association in the mental domain.

title: Factors Affecting Gender Differences in the Association between Health-Related Quality of Life and XXXX Components: Tehran Lipid and @entity2 Study.

answer: @entity1


abstract: To evaluation the effect of experimental tonic cutaneous @entity0 on motor cortex excitability by means of @entity3 ( @entity3 ). Thirty healthy adults (male: 12, female: 18) were tested with @entity3 . @entity0 was induced by topical application of @entity2 cream (0.025%) on the skin overlying the flexor carpi radialis of dominant limb. And the cream had been under an occlusive dressing for 40 minutes until we removed it. Magnetic stimulation was performed to the contralateral cortex with a circular coil at 80% intensity of maximum stimulator output. MEPs were recorded at flexor carpi radialis (FCR), extensor carpi radialis (ECR) and opponens pollicis (OP) with constant isometric contraction of 10%, 30% maximal @entity1 (MVC). Main outcome measures the intensity of @entity0 by visual analog scale (VAS). The latency, amplitude and silent period of motor evoked potentials (MEPs). Values at baseline and 20, 40, 60, 80 minutes from applying @entity2 were compared. VAS score reached the peak value at 40 minutes. Amplitudes of MEPs at FCR progressively decreased up to 40 minutes than returned to nearly baseline value at 80 minutes. The decrease in MEP amplitude at FCR was accompanied by the increase in VAS score significantly and sustained for 20 min after washing out @entity2 cream. At ECR _ OP, we could not demonstrate any changes in amplitude with time. Silent period at FCR only was significantly prolonged with the increase in VAS score. The present findings support that noxious cutaneous stimulation inhibit motor cortex excitability by so-called cortico-cortical circuits.

title: Evaluations of inhibitory effect on the motor cortex by cutaneous @entity0 via application of XXXX .

answer: @entity2


abstract: To evaluation the effect of experimental tonic cutaneous @entity0 on motor cortex excitability by means of @entity3 ( @entity3 ). Thirty healthy adults (male: 12, female: 18) were tested with @entity3 . @entity0 was induced by topical application of @entity2 cream (0.025%) on the skin overlying the flexor carpi radialis of dominant limb. And the cream had been under an occlusive dressing for 40 minutes until we removed it. Magnetic stimulation was performed to the contralateral cortex with a circular coil at 80% intensity of maximum stimulator output. MEPs were recorded at flexor carpi radialis (FCR), extensor carpi radialis (ECR) and opponens pollicis (OP) with constant isometric contraction of 10%, 30% maximal @entity1 (MVC). Main outcome measures the intensity of @entity0 by visual analog scale (VAS). The latency, amplitude and silent period of motor evoked potentials (MEPs). Values at baseline and 20, 40, 60, 80 minutes from applying @entity2 were compared. VAS score reached the peak value at 40 minutes. Amplitudes of MEPs at FCR progressively decreased up to 40 minutes than returned to nearly baseline value at 80 minutes. The decrease in MEP amplitude at FCR was accompanied by the increase in VAS score significantly and sustained for 20 min after washing out @entity2 cream. At ECR _ OP, we could not demonstrate any changes in amplitude with time. Silent period at FCR only was significantly prolonged with the increase in VAS score. The present findings support that noxious cutaneous stimulation inhibit motor cortex excitability by so-called cortico-cortical circuits.

title: Evaluations of inhibitory effect on the motor cortex by cutaneous XXXX via application of @entity2 .

answer: @entity0


abstract: @entity3 exerts pronounced electrophysiologic effects in the @entity0 heart. The present study tested the hypothesis that the negative chronotropic action of @entity3 in the @entity1 sinus node is dependent on its degradation to @entity4 . Increasing doses of the following compounds were administered in the sinus nodal artery of 12 open chest @entity1 (either sex, 30-35 kg) anesthetized with @entity6 (30 mg/kg i.v.): @entity4 , @entity3 , alpha,beta @entity2 - @entity3 (AMPCPP) and beta,gamma @entity2 - @entity3 ( @entity7 ). Right atrial, His bundle and right ventricular electrograms as well as Lead II ECG and systemic arterial blood pressure were monitored continuously and recorded. The depressant effects of test compounds on the sinus node were assessed from the prolongation of sinus cycle length and the duration of junctional escape rhythm which they induced. Data were used to plot dose-response curves for the four test compounds. The order of potency was @entity4 greater than or equal to @entity3 greater than or equal to @entity7 much greater than AMPCPP = 0. In 3 of 12 @entity1 the emergence of junctional escape rhythm was observed after the highest dose of either @entity4 , @entity3 or @entity7 . In addition, @entity5 , a selective competitive inhibitor of @entity4 at P1-purinoceptor site, reduced the effects of maximal doses of @entity4 , @entity3 and @entity7 by 52 +/- 7, 67 +/- 8 and 72 +/- 6%, respectively (each, P less than .05; @entity7 vs. @entity4 , P less than .05). The present data indicate that the negative chronotropic action of @entity3 is due to its rapid catabolism to @entity4 and the action of @entity4 at P1-purinoceptor sites.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX mediates the negative chronotropic action of adenosine 5'-triphosphate in the @entity1 sinus node.

answer: @entity4


abstract: @entity3 exerts pronounced electrophysiologic effects in the @entity0 heart. The present study tested the hypothesis that the negative chronotropic action of @entity3 in the @entity1 sinus node is dependent on its degradation to @entity4 . Increasing doses of the following compounds were administered in the sinus nodal artery of 12 open chest @entity1 (either sex, 30-35 kg) anesthetized with @entity6 (30 mg/kg i.v.): @entity4 , @entity3 , alpha,beta @entity2 - @entity3 (AMPCPP) and beta,gamma @entity2 - @entity3 ( @entity7 ). Right atrial, His bundle and right ventricular electrograms as well as Lead II ECG and systemic arterial blood pressure were monitored continuously and recorded. The depressant effects of test compounds on the sinus node were assessed from the prolongation of sinus cycle length and the duration of junctional escape rhythm which they induced. Data were used to plot dose-response curves for the four test compounds. The order of potency was @entity4 greater than or equal to @entity3 greater than or equal to @entity7 much greater than AMPCPP = 0. In 3 of 12 @entity1 the emergence of junctional escape rhythm was observed after the highest dose of either @entity4 , @entity3 or @entity7 . In addition, @entity5 , a selective competitive inhibitor of @entity4 at P1-purinoceptor site, reduced the effects of maximal doses of @entity4 , @entity3 and @entity7 by 52 +/- 7, 67 +/- 8 and 72 +/- 6%, respectively (each, P less than .05; @entity7 vs. @entity4 , P less than .05). The present data indicate that the negative chronotropic action of @entity3 is due to its rapid catabolism to @entity4 and the action of @entity4 at P1-purinoceptor sites.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity4 mediates the negative chronotropic action of adenosine 5'-triphosphate in the XXXX sinus node.

answer: @entity1


abstract: This 3-week prospective, randomized, double-masked, parallel-group study compared @entity4 fumarate 0.025% ophthalmic solution and @entity5 0.1% ophthalmic solution in 66 @entity0 with @entity2 . The drugs were instilled twice daily. Signs and symptoms were assessed on days 5 (visit 2) and 21 (visit 3). Other efficacy variables were the responder rate ( @entity0 with excellent or good global efficacy on days 5 and 21) and @entity0 and investigator ratings of global efficacy. Comfort was evaluated immediately after instillation of the first drop and at each follow-up visit. The frequency of adverse events was the safety assessment. The responder rate was higher with @entity4 than with @entity5 on day 5 (72% vs 54% for @entity0 assessment, 88% vs 55% for investigator assessment) and day 21 (91% vs 55%, 94% vs 42%). Global efficacy ratings were higher with @entity4 , and severity scores for @entity3 and itching were significantly lower. Both drugs elicited comparable comfort ratings. The most common adverse events were burning/stinging and @entity1 .

title: @entity4 and XXXX in the treatment of @entity2 : a real-world comparison of efficacy and ocular comfort.

answer: @entity5


abstract: This 3-week prospective, randomized, double-masked, parallel-group study compared @entity4 fumarate 0.025% ophthalmic solution and @entity5 0.1% ophthalmic solution in 66 @entity0 with @entity2 . The drugs were instilled twice daily. Signs and symptoms were assessed on days 5 (visit 2) and 21 (visit 3). Other efficacy variables were the responder rate ( @entity0 with excellent or good global efficacy on days 5 and 21) and @entity0 and investigator ratings of global efficacy. Comfort was evaluated immediately after instillation of the first drop and at each follow-up visit. The frequency of adverse events was the safety assessment. The responder rate was higher with @entity4 than with @entity5 on day 5 (72% vs 54% for @entity0 assessment, 88% vs 55% for investigator assessment) and day 21 (91% vs 55%, 94% vs 42%). Global efficacy ratings were higher with @entity4 , and severity scores for @entity3 and itching were significantly lower. Both drugs elicited comparable comfort ratings. The most common adverse events were burning/stinging and @entity1 .

title: @entity4 and @entity5 in the treatment of XXXX : a real-world comparison of efficacy and ocular comfort.

answer: @entity2


abstract: This 3-week prospective, randomized, double-masked, parallel-group study compared @entity4 fumarate 0.025% ophthalmic solution and @entity5 0.1% ophthalmic solution in 66 @entity0 with @entity2 . The drugs were instilled twice daily. Signs and symptoms were assessed on days 5 (visit 2) and 21 (visit 3). Other efficacy variables were the responder rate ( @entity0 with excellent or good global efficacy on days 5 and 21) and @entity0 and investigator ratings of global efficacy. Comfort was evaluated immediately after instillation of the first drop and at each follow-up visit. The frequency of adverse events was the safety assessment. The responder rate was higher with @entity4 than with @entity5 on day 5 (72% vs 54% for @entity0 assessment, 88% vs 55% for investigator assessment) and day 21 (91% vs 55%, 94% vs 42%). Global efficacy ratings were higher with @entity4 , and severity scores for @entity3 and itching were significantly lower. Both drugs elicited comparable comfort ratings. The most common adverse events were burning/stinging and @entity1 .

title: XXXX and @entity5 in the treatment of @entity2 : a real-world comparison of efficacy and ocular comfort.

answer: @entity4


abstract: BACKGROUND: @entity2 is a prevalent and clinically significant feature of @entity3 . However, there are aspects of @entity3 that have been minimally characterized. This study aims to fill several gaps in the literature by examining the prevalence, coexistence, and persistence of @entity2 retrospectively across a five-year period in @entity3 . METHODS: Fifty-one @entity0 with @entity3 I and comorbid @entity1 who were currently inter-episode completed the NIMH Retrospective Life-Charting Methodology (the life chart). The life chart was used to document the prevalence, coexistence, and persistence of @entity1 , @entity5 , delayed sleep phase, reduced sleep need, and irregular sleep patterns across the course of five years. RESULTS: Across the five year period, @entity3 months were primarily characterized by reduced sleep need (62.8%) and @entity1 (38.1%), @entity4 by @entity5 (56.0%) and @entity1 (51.9%), mixed months by all five types of @entity2 , and inter-episode months by @entity1 (67.4%). There was coexistence in the types of @entity2 experienced. Further, each type of @entity2 demonstrated persistence across the five years, with persistence rates being the highest for @entity1 (49.0-58.8%). CONCLUSIONS: @entity2 is a prevalent and complex feature across mood episodes and inter-episode periods of @entity3 . Further, there is variation in the types of @entity2 experienced.

title: A Retrospective Examination of Sleep Disturbance across the Course of XXXX .

answer: @entity3


abstract: UNASSIGNED: With the rising demand for renewable energy and environmental protection, anaerobic digestion of biogas technology has attracted considerable attention within the scientific community. The effect of physico-chemical pretreatment on cellulose degradation followed by fungal treatment by @entity5 and Trichoderma viride to treat cellulosic biomass for enhancing its digestibility was investigated. The tested substrate was digested with and without physical, chemical, and biological treatment. Fresh leaves, dry leaves and @entity1 dung were characterized by a total solids content 35, 84 and 17  %, volatile solids content 81.2, 59.49 and 64.5  % and C/N ratio 31, 45.4 and 13.6, respectively. Biogas total volume was determined using water replacement technique, while @entity2 volume was determined using precipitation of @entity3 in 20  % @entity4 solution. Pretreatment steps were carried out by using mechanical and chemical pretreatments using 2.5  % @entity4 mixed with 2.5  % @entity6 for 15  days, followed by biological treatment of A. terreus and T. viride. The potential of pretreatment of substrate was studied at regular intervals of 0, 7, 14, 21, 28, 35, 42, 49, 56, 63 and 70  days determining the change in chemical and physical compositions of used substrates. Biogas production was 102.6 and 125.9  L/KgVS from untreated and pretreated substrate, respectively. On the other hand, @entity2 production was 61.4 and 79.8  L/KgVS from untreated and pretreated substrate, respectively. In conclusion, Physical (milling), chemical ( @entity4 and @entity6 ) pretreatment in addition to fungal (A. terreus and T. viride) treatment for the tested substrate prior to @entity0 was an efficient process for improvement of biogas and @entity2 production.

title: Physico-chemical pretreatment and fungal biotreatment for park wastes and XXXX dung for biogas production.

answer: @entity1


abstract: AIM: To determine whether online diffusion of the "Ten Warning Signs of @entity2 ( @entity2 )'' adheres to accepted scientific standards. METHODS: We analyzed how reproducible is online diffusion of a unique instrument, the "Ten Warning Signs of @entity2 ", created by the Jeffrey Modell Foundation (JMF), by Google-assisted searches among highly visited sites from professional, @entity3 and scientific organizations; governmental agencies; and @entity0 support/advocacy organizations. We examined the diffusion, consistency of use and adequate referencing of this instrument. Where applicable, variant versions of the instrument were examined for changes in factual content that would have practical impact on physicians or on @entity0 and their families. RESULTS: Among the first 100 sites identified by Google search, 85 faithfully reproduced the JMF model, and correctly referenced to its source. By contrast, the other 15 also referenced the JMF source but presented one or more changes in content relative to their purported model and therefore represent uncontrolled variants, of unknown origin. Discrepancies identified in the latter included changes in factual content of the original JMF list (C), as well as removal (R) and introduction (I) of novel signs (Table 2), all made without reference to any scientific publications that might account for the drastic changes in factual content. Factual changes include changes in the number of @entity1 episodes considered necessary to raise suspicion of @entity2 , as well as the inclusion of various medical conditions not mentioned in the original. Together, these changes will affect the way physicians use the instrument to consult or to inform @entity0 , and the way @entity0 and families think about the need for specialist consultation in view of a possible @entity2 diagnosis. CONCLUSION: The retrieved adaptations and variants, which significantly depart from the original instrument, raise concerns about standards for scientific information provided online to physicians, @entity0 and families.

title: How reliable is online diffusion of medical information targeting XXXX and families?

answer: @entity0


abstract: BACKGROUND: Rosa damascena, a type of herb, has been used for wound healing in Eastern folk medicine. The goal of this study was to evaluate the effectiveness of rose placenta from R. damascena in a full-thickness wound model in @entity0 . METHODS: Sixty six-week-old C57BL/6 @entity0 were used. Full-thickness wounds were made with an 8-mm diameter punch. Two wounds were made on each side of the back, and wounds were assigned randomly to the control and experimental groups. Rose placenta (250   g) was injected in the experimental group, and normal saline was injected in the control group. Wound sizes were measured with digital photography, and specimens were harvested. Immunohistochemical staining was performed to assess the expression of @entity4 ( @entity4 ), @entity2 ( @entity2 ), @entity1 ( @entity1 ), and @entity3 . Vessel density was measured. Quantitative analysis using an enzyme-linked immunosorbent assay (ELISA) for @entity4 was performed. All evaluations were performed on postoperative days 0, 2, 4, 7, and 10. Statistical analyses were performed using the paired t-test. RESULTS: On days 4, 7, and 10, the wounds treated with rose placenta were significantly smaller. On day 2, @entity2 and @entity4 expression increased in the experimental group. On days 7 and 10, @entity1 expression decreased in the experimental group. On day 10, vessel density increased in the experimental group. The increase in @entity4 on day 2 was confirmed with ELISA. CONCLUSIONS: Rose placenta was found to be associated with improved wound healing in a @entity0 full-thickness wound model via increased @entity4 release. Rose placenta may potentially be a novel drug candidate for enhancing wound healing.

title: Wound Healing Effects of Rose Placenta in a XXXX Model of Full-Thickness Wounds.

answer: @entity0


abstract: BACKGROUND: It is still difficult to prevent partial or full-thickness flap @entity1 . In this study, the effects of a cream containing @entity2 and @entity3 on the viability of randompattern skin flaps were studied. METHODS: Forty female @entity0 were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing @entity2 and @entity3 was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap @entity1 was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. RESULTS: According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). CONCLUSIONS: Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

title: The Vasodilator Effect of a Cream Containing 10% XXXX and 15% @entity3 on Random-Pattern Skin Flaps in @entity0 .

answer: @entity2


abstract: BACKGROUND: It is still difficult to prevent partial or full-thickness flap @entity1 . In this study, the effects of a cream containing @entity2 and @entity3 on the viability of randompattern skin flaps were studied. METHODS: Forty female @entity0 were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing @entity2 and @entity3 was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap @entity1 was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. RESULTS: According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). CONCLUSIONS: Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

title: The Vasodilator Effect of a Cream Containing 10% @entity2 and 15% XXXX on Random-Pattern Skin Flaps in @entity0 .

answer: @entity3


abstract: BACKGROUND: It is still difficult to prevent partial or full-thickness flap @entity1 . In this study, the effects of a cream containing @entity2 and @entity3 on the viability of randompattern skin flaps were studied. METHODS: Forty female @entity0 were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing @entity2 and @entity3 was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap @entity1 was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. RESULTS: According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). CONCLUSIONS: Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

title: The Vasodilator Effect of a Cream Containing 10% @entity2 and 15% @entity3 on Random-Pattern Skin Flaps in XXXX .

answer: @entity0


abstract: Provider knowledge is a potential barrier to adherence to clinical guidelines. The purpose of this study is to assess the impact of organizational, provider, and guideline factors on provider knowledge of a @entity2 ( @entity2 ) clinical practice guideline (CPG) in the @entity1 ( @entity1 ) health care system. We developed a survey to investigate institution-level factors influencing the effectiveness of guideline implementation, including characteristics of the guideline, providers, hospital culture and structure, and regional network. Survey @entity0 were quality managers, primary care administrators, and other individuals involved in primary care CPG implementation at 143 @entity1 hospitals with ambulatory care clinics. Potential explanatory variables were grouped into 11 factors. Multivariate regression models assessed the association between these factors and reported levels of provider knowledge regarding the @entity2 guideline at the hospital level. Two hundred forty surveys from 126 of 143 (88%) @entity1 hospitals were returned. Provider knowledge of the @entity2 guideline was estimated as "great" or "very great" by 58% of respondents. Three predictor factors (dissemination approaches, use of technology in guideline implementation, and hospital culture) were independently associated (P < or = .05) with provider knowledge. Specific variables within these categories that were related to greater knowledge included physician belief that guidelines were applicable to their practice, distribution of guideline summaries, use of guideline storyboards in clinic areas, the use of technology (eg, electronic @entity0 records) in CPG implementation, and establishment of implementation checkpoints and deadlines. Provider knowledge of guidelines is affected by factors at various organizational levels: dissemination approaches, use of technology, and hospital culture. Guideline implementation efforts that target multiple organizational levels may increase provider knowledge.

title: What factors influence provider knowledge of a XXXX guideline in a national health care system?

answer: @entity2


abstract: @entity8 causes @entity1 in up to 50% of survivors. Two pathogens known for their propensity to cause severe @entity1 are @entity3 and group B streptococci. Some forms of neuronal sequelae, such as @entity9 , have been associated with @entity5 in the hippocampus. To learn more about hippocampal injury in @entity6 , we performed a comparative study in @entity8 due to @entity7 and group B @entity3 , in which 11-day-old @entity0 @entity2 were infected intracisternally with either of the two pathogens. Histopathological examination of the @entity5 in the dentate gyrus of the hippocampus showed that @entity7 caused predominantly classical apoptotic cell death. Cells undergoing apoptosis were located only in the subgranular zone and stained positive for activated @entity4 and TUNEL. Furthermore, dividing progenitor cells seemed particularly sensitive to this form of cell death. Group B @entity3 was mainly responsible for a @entity4 -independent (and TUNEL-negative) form of cell death. Compared with the morphological features found in apoptosis (e.g., apoptotic bodies), this form of @entity5 was characterized by clusters of uniformly shrunken cells. It affected the dentate gyrus throughout the blade, showing no preferences for immature or mature neurons. Thus, depending on the infecting agent, @entity8 causes two distinct forms of cell injury in the dentate gyrus.

title: @entity8 causes two distinct forms of cellular damage in the hippocampal dentate gyrus in XXXX @entity2 .

answer: @entity0


abstract: @entity8 causes @entity1 in up to 50% of survivors. Two pathogens known for their propensity to cause severe @entity1 are @entity3 and group B streptococci. Some forms of neuronal sequelae, such as @entity9 , have been associated with @entity5 in the hippocampus. To learn more about hippocampal injury in @entity6 , we performed a comparative study in @entity8 due to @entity7 and group B @entity3 , in which 11-day-old @entity0 @entity2 were infected intracisternally with either of the two pathogens. Histopathological examination of the @entity5 in the dentate gyrus of the hippocampus showed that @entity7 caused predominantly classical apoptotic cell death. Cells undergoing apoptosis were located only in the subgranular zone and stained positive for activated @entity4 and TUNEL. Furthermore, dividing progenitor cells seemed particularly sensitive to this form of cell death. Group B @entity3 was mainly responsible for a @entity4 -independent (and TUNEL-negative) form of cell death. Compared with the morphological features found in apoptosis (e.g., apoptotic bodies), this form of @entity5 was characterized by clusters of uniformly shrunken cells. It affected the dentate gyrus throughout the blade, showing no preferences for immature or mature neurons. Thus, depending on the infecting agent, @entity8 causes two distinct forms of cell injury in the dentate gyrus.

title: XXXX causes two distinct forms of cellular damage in the hippocampal dentate gyrus in @entity0 @entity2 .

answer: @entity8


abstract: @entity8 causes @entity1 in up to 50% of survivors. Two pathogens known for their propensity to cause severe @entity1 are @entity3 and group B streptococci. Some forms of neuronal sequelae, such as @entity9 , have been associated with @entity5 in the hippocampus. To learn more about hippocampal injury in @entity6 , we performed a comparative study in @entity8 due to @entity7 and group B @entity3 , in which 11-day-old @entity0 @entity2 were infected intracisternally with either of the two pathogens. Histopathological examination of the @entity5 in the dentate gyrus of the hippocampus showed that @entity7 caused predominantly classical apoptotic cell death. Cells undergoing apoptosis were located only in the subgranular zone and stained positive for activated @entity4 and TUNEL. Furthermore, dividing progenitor cells seemed particularly sensitive to this form of cell death. Group B @entity3 was mainly responsible for a @entity4 -independent (and TUNEL-negative) form of cell death. Compared with the morphological features found in apoptosis (e.g., apoptotic bodies), this form of @entity5 was characterized by clusters of uniformly shrunken cells. It affected the dentate gyrus throughout the blade, showing no preferences for immature or mature neurons. Thus, depending on the infecting agent, @entity8 causes two distinct forms of cell injury in the dentate gyrus.

title: @entity8 causes two distinct forms of cellular damage in the hippocampal dentate gyrus in @entity0 XXXX .

answer: @entity2


abstract: The objective of this study was to compare the DVE/OEB system (DVE = truly absorbed protein in the small intestine; OEB = degraded protein balance) and the NRC-2001 model in the prediction of supply of protein to dairy @entity0 from selected forages: alfalfa (Medicago sativa L. cv. Pioneer and Beaver) and timothy (Phleum pratense L. cv. Climax and Joliette). Comparisons were made in terms of 1) ruminally synthesized microbial CP, 2) truly absorbed protein in the small intestine, and 3) degraded protein balance. In addition, the effects of variety and cutting stage of the selected forages on the potential nutrient supply to dairy @entity0 were also studied. The results showed that the predicted values from the DVE/OEB system and the NRC-2001 model had significant correlations with high R (>0.96) values. However, using the DVE/OEB system, the overall average microbial protein supply based on available energy was 12% higher, and the truly absorbed protein in the small intestine was 15% lower than that predicted by the NRC-2001 model. The difference was also found in the prediction of the degraded protein balances, which was 11% higher based on data from the NRC-2001 model. These differences are due to considerably different factors used in calculations in the two models, although both are based on similar principles. This indicates that a further refinement is needed for a modern protein evaluation and prediction system. In addition, this study showed that the two alfalfa varieties studied (Pioneer vs. Beaver) had no effect, but cutting stage had a profound influence on ruminally synthesized microbial CP (93, 96, 86 g/kg @entity1 at stage of early bud, late bud, and early bloom, respectively) and truly absorbed intestinal protein predicted by the DVE/OEB system (80, 79, 67 g/kg @entity1 at stage of early bud, late bud, and early bloom, respectively). With timothy, both variety (Climax vs. Joliette) and cutting stage had significant impacts on the potential protein supply predicted by both models. The potential protein supply (DVE or MP) to the dairy @entity0 from Climax timothy was higher than that from Joliette timothy (DVE: 46 vs. 32 g/kg @entity1 ; MP: 61 vs. 38 g/kg @entity1 ). With increasing stage of cutting, the potential protein supply (DVE or MP) was reduced (DVE: 53, 39, 25 g/kg @entity1 ; MP: 62, 51, 36 g/kg @entity1 at stage of joint, prebloom head, and full head, respectively).

title: Comparison of the National Research Council-2001 model with the Dutch system (DVE/OEB) in the prediction of nutrient supply to dairy XXXX from forages.

answer: @entity0


abstract: OBJECTIVE: Research into @entity2 ( @entity2 ) following paediatric @entity1 ( @entity1 ) is limited. The current study investigated the frequency of @entity2 following paediatric @entity1 and the relationship between @entity2 and injury characteristics including severity, site of impact and cause of injury. It was hypothesized that @entity0 with moderate/severe @entity1 would demonstrate greater @entity2 than those with mild @entity1 . DESIGN/METHOD: Thirty-seven @entity0 aged 8-16 with @entity1 were recruited to a prospective longitudinal study at a metropolitan @entity0 's hospital. Olfactory assessment, using the University of Pennsylvania Smell Identification Test, was completed at 0-3 months post-injury. RESULTS: Nineteen per cent of @entity0 demonstrated impaired olfaction, while a small number (5%) were anosmic. A significant relationship between @entity2 and severity of injury was found. No other injury variables demonstrated a significant relationship with olfactory outcomes. CONCLUSIONS: @entity2 was relatively common in this paediatric @entity1 cohort and the hypothesized relationship with severity of injury was supported. It is recommended that information about @entity2 after @entity1 be routinely provided to @entity0 and families. Further research is needed in larger cohorts to support the implementation of routine clinical assessment, understand the relationship between @entity2 and other injury characteristics, determine the functional implications of @entity2 and document recovery trajectories.

title: Anosmia and olfactory outcomes following paediatric XXXX .

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity6 ) is a natural inhibitor of tissue @entity3 . In a previous study, we observed the positive association between abnormal concentrations of uncarboxylated @entity6 species and increased mortality risk in stable vascular @entity0 . We explore whether co-incidence of abnormal status of uncarboxylated @entity4 and @entity2 ( @entity2 ) affects the mortality risk. METHODS: We examined 799 @entity0 (mean age 65.1years) with stable @entity1 and followed them in a prospective study. Both, desphospho-uncarboxylated and total uncarboxylated @entity6 (dp-ucMGP or t-ucMGP) were quantified by pre-commercial ELISA assays. RESULTS: Elevated (>100ng/L) circulating @entity5 ( @entity5 ) and abnormal status of plasma uncarboxylated @entity6 species (i.e.: dp-ucMGP >= 977pmol/L or t-ucMGP <=2825nmol/L) were all identified as robust predictors of all-cause 5-year mortality. However, their co-incidence represented a substantial additional risk. We observed the highest mortality risk in @entity0 with elevated @entity5 plus high dp-ucMGP compared to those with normal @entity5 plus low dp-ucMGP; fully adjusted HRR's were 4.86 (3.15-7.49). Likewise, the risk was increased when compared with @entity0 with elevated @entity5 plus low dp-ucMGP; HRR 2.57 (1.60-4.10). Similar result we observed when co-incidence of elevated @entity5 and low t-ucMGP was analyzed [corresponding HRR's were 4.16 (2.62-6.61) and 1.96 (1.24-3.12)]. CONCLUSIONS: The concomitant abnormality of uncarboxylated @entity6 and mild elevation of @entity5 leads in chronic @entity0 with @entity1 to about two-fold increase of the relative mortality risk. We hypothesize that abnormal homeostasis of @entity6 is involved in the pathophysiology of @entity2 .

title: The abnormal status of uncarboxylated XXXX species represents an additional mortality risk in @entity2 @entity0 with @entity1 .

answer: @entity6


abstract: BACKGROUND: @entity6 ( @entity6 ) is a natural inhibitor of tissue @entity3 . In a previous study, we observed the positive association between abnormal concentrations of uncarboxylated @entity6 species and increased mortality risk in stable vascular @entity0 . We explore whether co-incidence of abnormal status of uncarboxylated @entity4 and @entity2 ( @entity2 ) affects the mortality risk. METHODS: We examined 799 @entity0 (mean age 65.1years) with stable @entity1 and followed them in a prospective study. Both, desphospho-uncarboxylated and total uncarboxylated @entity6 (dp-ucMGP or t-ucMGP) were quantified by pre-commercial ELISA assays. RESULTS: Elevated (>100ng/L) circulating @entity5 ( @entity5 ) and abnormal status of plasma uncarboxylated @entity6 species (i.e.: dp-ucMGP >= 977pmol/L or t-ucMGP <=2825nmol/L) were all identified as robust predictors of all-cause 5-year mortality. However, their co-incidence represented a substantial additional risk. We observed the highest mortality risk in @entity0 with elevated @entity5 plus high dp-ucMGP compared to those with normal @entity5 plus low dp-ucMGP; fully adjusted HRR's were 4.86 (3.15-7.49). Likewise, the risk was increased when compared with @entity0 with elevated @entity5 plus low dp-ucMGP; HRR 2.57 (1.60-4.10). Similar result we observed when co-incidence of elevated @entity5 and low t-ucMGP was analyzed [corresponding HRR's were 4.16 (2.62-6.61) and 1.96 (1.24-3.12)]. CONCLUSIONS: The concomitant abnormality of uncarboxylated @entity6 and mild elevation of @entity5 leads in chronic @entity0 with @entity1 to about two-fold increase of the relative mortality risk. We hypothesize that abnormal homeostasis of @entity6 is involved in the pathophysiology of @entity2 .

title: The abnormal status of uncarboxylated @entity6 species represents an additional mortality risk in @entity2 @entity0 with XXXX .

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity6 ) is a natural inhibitor of tissue @entity3 . In a previous study, we observed the positive association between abnormal concentrations of uncarboxylated @entity6 species and increased mortality risk in stable vascular @entity0 . We explore whether co-incidence of abnormal status of uncarboxylated @entity4 and @entity2 ( @entity2 ) affects the mortality risk. METHODS: We examined 799 @entity0 (mean age 65.1years) with stable @entity1 and followed them in a prospective study. Both, desphospho-uncarboxylated and total uncarboxylated @entity6 (dp-ucMGP or t-ucMGP) were quantified by pre-commercial ELISA assays. RESULTS: Elevated (>100ng/L) circulating @entity5 ( @entity5 ) and abnormal status of plasma uncarboxylated @entity6 species (i.e.: dp-ucMGP >= 977pmol/L or t-ucMGP <=2825nmol/L) were all identified as robust predictors of all-cause 5-year mortality. However, their co-incidence represented a substantial additional risk. We observed the highest mortality risk in @entity0 with elevated @entity5 plus high dp-ucMGP compared to those with normal @entity5 plus low dp-ucMGP; fully adjusted HRR's were 4.86 (3.15-7.49). Likewise, the risk was increased when compared with @entity0 with elevated @entity5 plus low dp-ucMGP; HRR 2.57 (1.60-4.10). Similar result we observed when co-incidence of elevated @entity5 and low t-ucMGP was analyzed [corresponding HRR's were 4.16 (2.62-6.61) and 1.96 (1.24-3.12)]. CONCLUSIONS: The concomitant abnormality of uncarboxylated @entity6 and mild elevation of @entity5 leads in chronic @entity0 with @entity1 to about two-fold increase of the relative mortality risk. We hypothesize that abnormal homeostasis of @entity6 is involved in the pathophysiology of @entity2 .

title: The abnormal status of uncarboxylated @entity6 species represents an additional mortality risk in XXXX @entity0 with @entity1 .

answer: @entity2


abstract: BACKGROUND: @entity6 ( @entity6 ) is a natural inhibitor of tissue @entity3 . In a previous study, we observed the positive association between abnormal concentrations of uncarboxylated @entity6 species and increased mortality risk in stable vascular @entity0 . We explore whether co-incidence of abnormal status of uncarboxylated @entity4 and @entity2 ( @entity2 ) affects the mortality risk. METHODS: We examined 799 @entity0 (mean age 65.1years) with stable @entity1 and followed them in a prospective study. Both, desphospho-uncarboxylated and total uncarboxylated @entity6 (dp-ucMGP or t-ucMGP) were quantified by pre-commercial ELISA assays. RESULTS: Elevated (>100ng/L) circulating @entity5 ( @entity5 ) and abnormal status of plasma uncarboxylated @entity6 species (i.e.: dp-ucMGP >= 977pmol/L or t-ucMGP <=2825nmol/L) were all identified as robust predictors of all-cause 5-year mortality. However, their co-incidence represented a substantial additional risk. We observed the highest mortality risk in @entity0 with elevated @entity5 plus high dp-ucMGP compared to those with normal @entity5 plus low dp-ucMGP; fully adjusted HRR's were 4.86 (3.15-7.49). Likewise, the risk was increased when compared with @entity0 with elevated @entity5 plus low dp-ucMGP; HRR 2.57 (1.60-4.10). Similar result we observed when co-incidence of elevated @entity5 and low t-ucMGP was analyzed [corresponding HRR's were 4.16 (2.62-6.61) and 1.96 (1.24-3.12)]. CONCLUSIONS: The concomitant abnormality of uncarboxylated @entity6 and mild elevation of @entity5 leads in chronic @entity0 with @entity1 to about two-fold increase of the relative mortality risk. We hypothesize that abnormal homeostasis of @entity6 is involved in the pathophysiology of @entity2 .

title: The abnormal status of uncarboxylated @entity6 species represents an additional mortality risk in @entity2 XXXX with @entity1 .

answer: @entity0


abstract: OBJECTIVE: To investigate the prevalence of @entity2 , the prevalence of utilization of @entity1 ( @entity1 ) measurements for diagnosis of @entity2 , and prevalence of use of @entity3 and @entity4 supplements and other antiresorptive therapies for treatment of @entity2 in postmenopausal @entity0 in an academic nursing home. METHODS: The charts of all @entity0 aged 56 years and older residing in an academic nursing home were analyzed by one of the authors for the prevalence of @entity2 , the prevalence of use of @entity1 measurements to diagnose @entity2 , and the prevalence of use of @entity3 and @entity4 supplements and other antiresorptive therapies for treatment of @entity2 . RESULTS: Of 136 postmenopausal @entity0 , mean age 79 +/- 10 years, 66 (49%) had measurements of @entity1 . Of these 66 @entity0 , 31 (47%) had @entity2 , 21 (32%) had @entity5 , and 14 (21%) had normal @entity1 . Elemental @entity6 1500 mg daily was prescribed to 17 of 31 @entity0 (55%) with @entity2 , to 12 of 21 @entity0 (57%) with @entity5 , to 2 of 14 @entity0 (14%) with normal @entity1 , and to 27 of 70 @entity0 (39%) with no @entity1 obtained. Any dose of @entity3 was prescribed to 78 of 136 elderly @entity0 (58%). @entity4 supplements were prescribed to 13 of 31 @entity0 (42%) with @entity2 , to 9 of 21 @entity0 (43%) with @entity5 , to 2 of 14 @entity0 (14%) with normal @entity1 , and to 20 of 70 @entity0 (29%) with no @entity1 obtained. @entity4 supplements were prescribed to 44 of 136 elderly @entity0 (32%). Biphosphonates were prescribed to 19 of 31 @entity0 (61%) with @entity2 . Of 20 @entity0 on medications that increased the risk of @entity2 , 6 (30%) had @entity1 measured. Nine of these 20 @entity0 (45%) were on @entity3 supplements. CONCLUSIONS: Older postmenopausal @entity0 in an academic nursing home have a high prevalence of @entity2 and @entity5 , a low prevalence of measurement of @entity1 , and underuse of @entity3 , @entity4 supplements, and other antiresorptive therapies for treatment of @entity2 .

title: Underuse of procedures for diagnosing @entity2 and of therapies for XXXX in older nursing home residents.

answer: @entity2


abstract: OBJECTIVE: To investigate the prevalence of @entity2 , the prevalence of utilization of @entity1 ( @entity1 ) measurements for diagnosis of @entity2 , and prevalence of use of @entity3 and @entity4 supplements and other antiresorptive therapies for treatment of @entity2 in postmenopausal @entity0 in an academic nursing home. METHODS: The charts of all @entity0 aged 56 years and older residing in an academic nursing home were analyzed by one of the authors for the prevalence of @entity2 , the prevalence of use of @entity1 measurements to diagnose @entity2 , and the prevalence of use of @entity3 and @entity4 supplements and other antiresorptive therapies for treatment of @entity2 . RESULTS: Of 136 postmenopausal @entity0 , mean age 79 +/- 10 years, 66 (49%) had measurements of @entity1 . Of these 66 @entity0 , 31 (47%) had @entity2 , 21 (32%) had @entity5 , and 14 (21%) had normal @entity1 . Elemental @entity6 1500 mg daily was prescribed to 17 of 31 @entity0 (55%) with @entity2 , to 12 of 21 @entity0 (57%) with @entity5 , to 2 of 14 @entity0 (14%) with normal @entity1 , and to 27 of 70 @entity0 (39%) with no @entity1 obtained. Any dose of @entity3 was prescribed to 78 of 136 elderly @entity0 (58%). @entity4 supplements were prescribed to 13 of 31 @entity0 (42%) with @entity2 , to 9 of 21 @entity0 (43%) with @entity5 , to 2 of 14 @entity0 (14%) with normal @entity1 , and to 20 of 70 @entity0 (29%) with no @entity1 obtained. @entity4 supplements were prescribed to 44 of 136 elderly @entity0 (32%). Biphosphonates were prescribed to 19 of 31 @entity0 (61%) with @entity2 . Of 20 @entity0 on medications that increased the risk of @entity2 , 6 (30%) had @entity1 measured. Nine of these 20 @entity0 (45%) were on @entity3 supplements. CONCLUSIONS: Older postmenopausal @entity0 in an academic nursing home have a high prevalence of @entity2 and @entity5 , a low prevalence of measurement of @entity1 , and underuse of @entity3 , @entity4 supplements, and other antiresorptive therapies for treatment of @entity2 .

title: Underuse of procedures for diagnosing XXXX and of therapies for @entity2 in older nursing home residents.

answer: @entity2


abstract: UNASSIGNED: In the @entity2 of chemoimmunotherapy, the optimal treatment paradigm for relapsed and refractory diffuse large @entity1 has been challenged. We reviewed the outcome of standard salvage therapy with an autologous stem cell transplant (autoSCT) over the last two decades and the outcome of @entity3 ( @entity3 ) in the most recent decade. AutoSCT recipients diagnosed between 1992 and 2002 (n=2737) were compared with those diagnosed between 2002 and 2010 (n=3980). @entity0 diagnosed after 2002 had a significantly lower non-relapse mortality (NRM) and relapse incidence (RI) and a superior PFS and overall survival (OS). A total of 4210 @entity0 diagnosed between 2002 and 2010 underwent either an autoSCT or an @entity3 as their first transplant procedure. Two-hundred and thirty @entity0 received an @entity3 (myeloablative (MACalloSCT) n=132, reduced intensity (RICalloSCT) n=98). The 4-year NRM rates were 7%, 20% and 27% for autoSCT, RICalloSCT and MACalloSCT, respectively. The 4-year RI was 45%, 40% and 38% for autoSCT, RICalloSCT and MACalloSCT, respectively (NS). The 4-year PFS were 48%, 52% and 35% for autoSCT, RICalloSCT and MACalloSCT, respectively. The 4-year OS was 60%, 52% and 38% for autoSCT, RIC @entity3 and MACalloSCT, respectively. After adjustment for confounding factors NRM was significantly worse for @entity0 undergoing @entity3 whilst there was no difference in the RI.Bone Marrow Transplantation advance online publication, 30 November 2015; doi:10.1038/bmt.2015.286.

title: Autologous stem cell transplantation for relapsed/refractory diffuse large XXXX : efficacy in the rituximab @entity2 and comparison to first allogeneic transplants. A report from the EBMT Lymphoma Working Party.

answer: @entity1


abstract: UNASSIGNED: In the @entity2 of chemoimmunotherapy, the optimal treatment paradigm for relapsed and refractory diffuse large @entity1 has been challenged. We reviewed the outcome of standard salvage therapy with an autologous stem cell transplant (autoSCT) over the last two decades and the outcome of @entity3 ( @entity3 ) in the most recent decade. AutoSCT recipients diagnosed between 1992 and 2002 (n=2737) were compared with those diagnosed between 2002 and 2010 (n=3980). @entity0 diagnosed after 2002 had a significantly lower non-relapse mortality (NRM) and relapse incidence (RI) and a superior PFS and overall survival (OS). A total of 4210 @entity0 diagnosed between 2002 and 2010 underwent either an autoSCT or an @entity3 as their first transplant procedure. Two-hundred and thirty @entity0 received an @entity3 (myeloablative (MACalloSCT) n=132, reduced intensity (RICalloSCT) n=98). The 4-year NRM rates were 7%, 20% and 27% for autoSCT, RICalloSCT and MACalloSCT, respectively. The 4-year RI was 45%, 40% and 38% for autoSCT, RICalloSCT and MACalloSCT, respectively (NS). The 4-year PFS were 48%, 52% and 35% for autoSCT, RICalloSCT and MACalloSCT, respectively. The 4-year OS was 60%, 52% and 38% for autoSCT, RIC @entity3 and MACalloSCT, respectively. After adjustment for confounding factors NRM was significantly worse for @entity0 undergoing @entity3 whilst there was no difference in the RI.Bone Marrow Transplantation advance online publication, 30 November 2015; doi:10.1038/bmt.2015.286.

title: Autologous stem cell transplantation for relapsed/refractory diffuse large @entity1 : efficacy in the rituximab XXXX and comparison to first allogeneic transplants. A report from the EBMT Lymphoma Working Party.

answer: @entity2


abstract: OBJECTIVES: To present our experience with extracorporeal shock wave lithotripsy (ESWL) in @entity0 with @entity1 and to determine the factors that may influence the stone-free rate in such @entity0 . METHODS: From February 1989 to February 2000, 198 @entity0 were treated for @entity1 using ESWL. The mean @entity0 age (SD) was 40.48 (11.53) years. The kidneys were horseshoe in 49 (24.7%), malrotated in 120 (60.6%), and duplex in 29 (14.7%). All @entity0 were treated on an outpatient basis using two second-generation lithotripters (Dornier MFL 5000 and Toshiba Echolith). Pretreatment auxiliary measures were required in 6 @entity0 (3%). Follow-up data were recorded at 3 months. The statistical analysis was performed using the chi-square and Mann-Whitney U tests, with differences considered statistically significant if P <0.05. RESULTS: The mean stone length (SD) was 13.54 (5.49) mm. The stones were single in 148 (74.7%), of new onset in 155 (78.3%), and on the right side in 82 (41.4%). All stones, but 5 (2.5%), were radiopaque. The overall stone-free rate was 72.2%. Neither the type of @entity1 nor the type of lithotripter had any impact on the stone-free rate (P >0.05). Stone burden (length and number) had a significant influence on the stone-free rate (P <0.05). No extraordinary complications were recorded. Steinstrasse developed in 7 @entity0 (3.5%). No deterioration of renal function or configuration was detected. CONCLUSIONS: ESWL is safe and reliable for treatment of @entity1 . It should be the primary therapy when the stones are less than 20 mm. The ESWL outcome is comparable for normal and @entity1 when the calculus size is considered.

title: Extracorporeal shock wave lithotripsy in XXXX : 11-year experience with two second-generation lithotripters.

answer: @entity1


abstract: OBJECTIVES: To determine the effectiveness of immediate surgical exploration in salvaging perinatal testicular torsion. METHODS: A retrospective analysis from 1995 to 2000 of @entity0 younger than 30 days of age with surgically documented extravaginal testicular torsion was conducted. All cases were diagnosed after a normal testicular examination by a neonatologist, and all @entity0 underwent urgent exploration to confirm the exact diagnosis and attempt testicular salvage by detorsion with bilateral orchiopexy. If a nonviable @entity1 was determined intraoperatively, it was removed and contralateral orchiopexy was performed. Success was determined by physical examination at 6 months of follow-up. RESULTS: Ten @entity0 with 10 affected testes were identified and a total of 4 (40%) were salvaged. All the studied testes were right-sided, and of the 4 salvaged testes, all were palpably normal and equal in size to their mate at the 6-month follow-up examination. Of the 6 removed testes, 1 was potentially viable by permanent pathologic section analysis despite preoperative ultrasonography demonstrating no flow and a negative intraoperative bleed test. CONCLUSIONS: @entity0 younger than 30 days old presenting with clinical findings suggestive of extravaginal testicular torsion who are expeditiously explored surgically may have a salvageable event in at least 40% to 50%. These statistics are similar to the salvage rates found with the similar management approach of intravaginal torsion.

title: Perinatal extravaginal torsion of the XXXX in the first month of life is a salvageable event.

answer: @entity1


abstract: OBJECTIVES: To use a geographic information system (GIS) and spatial statistics to describe the geographic variation of @entity1 in @entity0 0-14 years of age in a major metropolitan area. METHODS: The authors reviewed @entity0 records for @entity1 treated during 1995 at the two @entity0 's hospitals in St. Louis. @entity0 addresses were matched to block groups using a GIS, and block group @entity1 rates were calculated. Mapping software and Bayesian analysis were used to create maps of @entity1 rates and risks in the city of St. Louis. RESULTS: Three hundred eleven @entity0 from the city of St. Louis were treated for @entity1 in 1995. The authors identified an area of high incidence for @entity1 in North St. Louis. The filtered rate contour was 6 per 1,000 @entity0 at risk, with block group rates within the area of 0 to 58.8 per 1,000 @entity0 at risk. Hierarchical Bayesian analysis of North St. Louis burn data revealed a relative risk range of 0.8771 to 1.182 for census tracts within North St. Louis, suggesting that there may be pockets of high risk within an already identified high-risk area. CONCLUSIONS: This study shows the utility of geographic mapping in providing information about injury patterns within a defined area. The combination of mapping injury rates and spatial statistical analysis provides a detailed level of injury surveillance, allowing for identification of small geographic areas with elevated rates of specific injuries.

title: Geographic variation of pediatric XXXX in a metropolitan area.

answer: @entity1


abstract: Multiple failures of antiretroviral treatments, as a result of multidrug-resistant virus, have led to a proposal for structured therapeutic interruptions (STI). However, a significant decrease in @entity1 + T cells may occur. The aim of our study was to determine the kinetics of T cell subpopulation changes, T cell apoptosis and peripheral blood mononuclear cell proliferation after STI. The impact of resistance mutation disappearance on T cell apoptosis was also studied. Ten @entity0 were enrolled prospectively, and blood sampling was performed at weeks 0, 2, 4, 6, 8 and 12. The mean increase in viral load was 1.3 log(10) copies/ml, ranging from 0.1 to 3.2. @entity1 + T cell count decreased to a mean of 80 cells/mm(3) from baseline to week 12. In the same period, @entity2 + T cells decreased to a mean of 139 cells/mm(3). A significant increase in both T cell apoptosis and proliferation of mononuclear cells was observed. However, proliferation was an early and brief event. The increase in @entity1 + T cell apoptosis was obvious in @entity0 exhibiting complete reversion of resistance mutations to antiviral drugs. Our results suggest that during STI, apoptosis is an overwhelming phenomenon compared with proliferation, and may explain the limited immunological impact of this therapeutic option.

title: Apoptosis and proliferation kinetics of T cells in XXXX having experienced antiretroviral treatment interruptions.

answer: @entity0


abstract: BACKGROUND: Female survivors of @entity4 ( @entity4 ) have a strongly elevated risk of @entity0 , but factors responsible for the increased risk are not well known. METHODS: We investigated the effects of radiation dose, chemotherapy (CT), and reproductive factors on @entity0 risk in a nested case-control study in The Netherlands in a cohort of 770 female @entity1 who had been diagnosed with @entity4 before age 41. Detailed treatment information and data on reproductive factors were collected for 48 case @entity1 who developed @entity0 5 or more years after diagnosis of @entity4 and 175 matched control subjects. The radiation dose was estimated to the area of the breast where the case @entity1 's @entity2 had developed and to a comparable location in matched control subjects. Relative risks (RRs) of @entity0 were calculated by conditional logistic regression. Statistical tests were two-sided. RESULTS: The risk of @entity0 increased statistically significantly with radiation dose (P(trend) =.01); @entity1 who received 38.5 Gy or more had an RR of 4.5 (95% confidence interval [CI] = 1.3 to 16) times that of @entity1 who received less than 4 Gy. @entity1 who received both CT and radiotherapy (RT) had a statistically significantly lower risk than those treated with RT alone (RR = 0.45, 95% CI = 0.22 to 0.91). @entity0 risk increased with increasing radiation dose among @entity1 who received RT only (RR = 12.7, 95% CI = 1.8 to 86, for @entity1 receiving > or =38.5 Gy) but not among @entity1 treated with CT and RT. Sixty-nine percent of control subjects treated with RT and more than six cycles of CT, but only 9% of those who received RT alone, reached menopause before age 41. Reaching menopause before age 36 was associated with a strongly reduced risk of @entity0 (RR = 0.06, 95% CI = 0.01 to 0.45). CONCLUSION: @entity0 risk increases with increasing radiation dose up to at least 40 Gy. The substantial risk reduction associated with CT may reflect its effect on menopausal age, suggesting that ovarian hormones promote @entity3 after radiation has produced an initiating event.

title: Roles of radiation dose, chemotherapy, and hormonal factors in @entity0 following XXXX .

answer: @entity4


abstract: BACKGROUND: Female survivors of @entity4 ( @entity4 ) have a strongly elevated risk of @entity0 , but factors responsible for the increased risk are not well known. METHODS: We investigated the effects of radiation dose, chemotherapy (CT), and reproductive factors on @entity0 risk in a nested case-control study in The Netherlands in a cohort of 770 female @entity1 who had been diagnosed with @entity4 before age 41. Detailed treatment information and data on reproductive factors were collected for 48 case @entity1 who developed @entity0 5 or more years after diagnosis of @entity4 and 175 matched control subjects. The radiation dose was estimated to the area of the breast where the case @entity1 's @entity2 had developed and to a comparable location in matched control subjects. Relative risks (RRs) of @entity0 were calculated by conditional logistic regression. Statistical tests were two-sided. RESULTS: The risk of @entity0 increased statistically significantly with radiation dose (P(trend) =.01); @entity1 who received 38.5 Gy or more had an RR of 4.5 (95% confidence interval [CI] = 1.3 to 16) times that of @entity1 who received less than 4 Gy. @entity1 who received both CT and radiotherapy (RT) had a statistically significantly lower risk than those treated with RT alone (RR = 0.45, 95% CI = 0.22 to 0.91). @entity0 risk increased with increasing radiation dose among @entity1 who received RT only (RR = 12.7, 95% CI = 1.8 to 86, for @entity1 receiving > or =38.5 Gy) but not among @entity1 treated with CT and RT. Sixty-nine percent of control subjects treated with RT and more than six cycles of CT, but only 9% of those who received RT alone, reached menopause before age 41. Reaching menopause before age 36 was associated with a strongly reduced risk of @entity0 (RR = 0.06, 95% CI = 0.01 to 0.45). CONCLUSION: @entity0 risk increases with increasing radiation dose up to at least 40 Gy. The substantial risk reduction associated with CT may reflect its effect on menopausal age, suggesting that ovarian hormones promote @entity3 after radiation has produced an initiating event.

title: Roles of radiation dose, chemotherapy, and hormonal factors in XXXX following @entity4 .

answer: @entity0


abstract: The cases of 208 @entity0 with histologically confirmed @entity9 were studied. The incidence represents 4.2% of all primary @entity6 diagnosed in the Norwegian population over a 25-year period. All of these @entity1 were cerebral and the majority affected the frontal lobe. The @entity0 ' median age at diagnosis was 47 years, with a range from 3 to 76 years; 6% of the @entity9 occurred in @entity0 . The median duration of symptoms before diagnosis was 20.5 months (mean 43 months). Plain skull x-ray films showed calcified deposits in 28% of the @entity1 . At operation, most of the @entity1 were poorly defined, without cyst formation, @entity7 @entity2 , or @entity5 . The median duration of disease from onset of symptoms until @entity4 was 14 months in nine untreated cases. In surgically treated @entity9 @entity0 the median survival time from onset of symptoms was 74 months. The median postoperative survival time was 35 months (mean 52 months). @entity1 @entity5 , as seen on plain skull x-ray films, was associated with a significantly longer survival period. The surgical findings of gross @entity2 , gross hypervascularity, and soft @entity1 consistency were all related to a @entity3 . Grossly well demarcated lesions were associated with a significantly longer postoperative survival. The length of postoperative survival correlated with the preoperative clinical status. The cumulative proportion of @entity0 surviving 5 years was 0.342. The @entity0 's age and sex did not have a statistically significant influence on survival time. The extent of surgical excision only seemed to play a role when the neurosurgeon considered that he had removed the whole lesion: these @entity0 had a median postoperative survival period 14 months longer than the other @entity9 @entity0 . The @entity10 blood group of the @entity9 @entity0 was of prognostic value. In particular, @entity0 with blood group A had a distinctly poorer prognosis than @entity0 with O or B blood. The survival data from this unselected series indicate that @entity8 have a less favorable prognosis than has generally been believed.

title: XXXX : incidence and biological behavior in a defined population.

answer: @entity9


abstract: OBJECTIVE: Patterns of pubertal maturation may have an impact on several risk factors associated with adult morbidity and mortality, such as @entity1 . We examined the relationship of the initial manifestation of puberty in @entity0 with anthropometric measures, as well as age at menarche. METHODS: White females (n = 1166, ages 9 and 10 at intake) were followed with annual visits for 10 years. Physical examinations included height, weight, skinfold thicknesses, and pubertal maturation assessment. RESULTS: During the course of the study, 443 of 859 eligible females (51.6%) were observed to have asynchronous maturation in the development of puberty, that is, initial areolar/breast (thelarche pathway) or pubic hair (adrenarche pathway) development, without development of the other characteristic. Using a longitudinal regression model, significant interactions were noted between initial pubertal manifestation and years since onset of puberty on the following outcomes: sum of skinfolds thickness, percent body fat, waist-to-hip ratio, and body mass index (BMI). However, age of onset of pubertal maturation was the same in the 2 groups (10.7 years). Females in the thelarche pathway had earlier menarche (12.6 vs 13.1 years) as well as greater skinfolds, body fat, and BMI at the time of menarche. Females in the thelarche pathway also had greater body fat and @entity2 year before puberty and throughout puberty compared with those in the adrenarche pathway. CONCLUSIONS: Females who enter puberty through the thelarche pathway, as compared with the adrenarche pathway, had greater sum of skinfold thicknesses, BMI, and percent body fat 1 year before the onset, as well as throughout, puberty. Because larger body composition and earlier age of menarche of females in the thelarche pathway parallel the epidemiologic profiles of @entity0 who are @entity1 or at risk for @entity1 , these females may be at greater risk for @entity1 .

title: Pubertal maturation in XXXX and the relationship to anthropometric changes: pathways through puberty.

answer: @entity0


abstract: BACKGROUND: Endoscopic management of @entity1 is controversial with respect to optimal types of stents and extent of drainage. This study evaluated outcomes of selective MRCP and CT-targeted drainage with self-expanding metallic stents. METHODS: Consecutive @entity0 undergoing attempted palliative ERCP for @entity1 were prospectively followed. Whenever possible, management strategy included evaluation and staging for potential resectability before ERCP, with primary placement of metallic stents at the first ERCP in nonsurgical candidates, and early conversion to a metallic stent when a @entity1 proved to be unresectable. MRCP and/or CT were used to plan selective guidewire access, opacification, and drainage only of the largest intercommunicating segmental ducts. Unilateral stent placement was intended in all cases except for selected @entity0 with @entity2 . RESULTS: Thirty-five @entity0 were included. Bismuth classification was I, 10; II, 6; III, 8; and IV, 11. Tumor origin was bile duct (17), gallbladder (5), and metastatic (13). Metallic stents were placed in 27 @entity0 as the initial stent, and in 8 after plastic stent placement. Initial stents were placed endoscopically in 33 @entity0 and percutaneously in 2 @entity0 in whom @entity1 precluded ERCP. Stent placement was unilateral in 31 @entity0 and bilateral in 4 @entity0 . There were no episodes of @entity3 or other complications within 30 days after any procedures. Initial metallic stents were clinically effective in 27 (77%) of the 35 @entity0 . Additional percutaneous drainage in 3 @entity0 who did not respond to initial stent placement did not resolve @entity4 . Median patency of first metallic stents was 8.9 months for @entity0 with @entity5 and 5.4 months for all @entity0 , and was not related to @entity6 classification. No further intervention was needed in 25 (71%) @entity0 . CONCLUSIONS: Unilateral metallic stent placement by using MRCP and/or CT to selectively target drainage provides safe and effective palliation in most @entity0 with @entity1 .

title: Selective MRCP and CT-targeted drainage of XXXX with self-expanding metallic stents.

answer: @entity1


abstract: INTRODUCTION: Nineteen cases of posterior interosseous artery (PIOA) flap were reviewed. The @entity0 ' mean age was 24 (range 14-53) years. MATERIALS AND METHODS: Nine @entity0 were operated on as emergencies, and 10 @entity0 were treated electively. Mean time of delay after @entity2 was 7.8 h (range 2-20 h) in emergency cases. Nine of them were non-replantable amputations. Skin defects were between 1.9 x 2.4 cm and 5.0 x 12.0 cm. Mean hospitalization time was 2.2 (range 1-5) days. RESULTS: Mean flap sensation was evaluated as 2.83-6.65 with the Semmes-Weinstein evaluation scale (only 2 @entity0 scored less than 3.61). Five @entity0 presented with discoloration and coolness. Average subjective evaluation was 8.2/10. Mean web opening after first web reconstruction was 40 degrees. One @entity4 ( recovered in 4 months), one @entity1 , and one flap lost (due to @entity3 ) occurred as early complications. Mean follow-up was 12.8 months (range 15 days to 30 months). CONCLUSIONS: PIOA flap applications have reduced the need for lateral arm and radial forearm flaps and also shortened hospitalization time in clinical practice.

title: Posterior interosseous artery flap in XXXX .

answer: @entity2


abstract: Increased milking frequency (IMF) at the beginning of lactation has been shown to increase @entity2 yield not only during IMF but also after its cessation. The objectives of this experiment evaluated the effects of increased milking frequency initiated during early lactation on mammary growth and effects on @entity2 yield (MY). Thirty-one @entity0 were divided into treatment groups: 1) 2X: @entity0 milked twice daily (2X) beginning at parturition (d 1), 2) IMF1: @entity0 milked four times daily (4X) from d 1 to 21 postpartum (PP) and 3) IMF4: @entity0 milked 2X d 1 to 3 and 4X d 4 to 21 PP. The 4X @entity0 were milked immediately before 2X @entity0 and again approximately 3 h later, at the end of the normal milking routine. All @entity0 were milked 2X from d 21 to 305 postpartum. @entity2 yields were 34.5, 37.8 and 37.6 kg/d during wk 1 to 44 for 2X, IMF1 and IMF4, respectively. Mammary biopsies from four @entity0 per treatment were obtained on d 7 and 14 PP to evaluate mammary cell proliferation. @entity1 incorporation tended to increase on d 7 in IMF1 @entity0 , and arithmetic means of the percentage of cells expressing Ki-67 proliferation antigen were consistent with a proliferative response to IMF though not significant. Blood was sampled three times per wk during the first 2 wk and then once per wk during wk 3, 4, 5, 6, 8, and 10. Plasma @entity3 ( @entity3 ) averaged 20.1 ng/ml in IMF @entity0 vs. 24.2 in 2X but was not accompanied by a change in bST. Prolactin was also not affected by treatment. Neither @entity2 yield nor potential effects on mammary cell proliferation were correlated with systemic @entity3 . Implementing an IMF routine increases MY during treatment and elicits a carryover effect on the remainder of lactation. @entity2 yield responses after an IMF routine may be the result of increased mammary cell proliferation.

title: XXXX yield and mammary growth effects due to increased milking frequency during early lactation.

answer: @entity2


abstract: OBJECTIVES: To evaluate the long-term effect and safety of @entity5 for the treatment of @entity3 after radical prostatectomy (RP). METHODS: The study consisted of 91 @entity0 with @entity3 from our institution who received oral @entity5 after RP. We surveyed these @entity0 using a self-administered questionnaire during the first year of @entity5 use to determine treatment satisfaction, @entity0 compliance, and safety. Those who had responded positively to the drug were surveyed again 3 years later (n = 48). @entity5 was prescribed at a dose of 50 mg and increased to 100 mg if needed. Data were collected from a self-administered questionnaire using the abridged five-item version of the International Index of Erectile Function questionnaire, referred to as the Sexual Health Inventory of @entity0 , and the @entity3 Inventory of Treatment Satisfaction. The @entity0 were stratified according to the type of nerve-sparing (NS) RP procedure they underwent: bilateral NS, unilateral NS, and non-NS. RESULTS: At 3 years, 31 (71%) of the 43 @entity0 who had returned the second surveys were still responding to @entity5 . Of these 31 respondents, 10 (31%) had augmented their dose from 50 to 100 mg. The dropout rate was 27%; 6 of 12 had discontinued because of the return of natural erections, 5 because of a loss of efficacy, and 1 because his spouse had died. No differences were found in the 1-year and 3-year five-item International Index of Erectile Function (Sexual Health Inventory of @entity0 ) and @entity3 Inventory of Treatment Satisfaction scores between the NS groups. The most common side effects at 3 years were @entity1 (12%), @entity4 (10%), and @entity2 (2%). No @entity0 discontinued the drug at 3 years because of side effects. CONCLUSIONS: The results of this study indicate that the vast majority of @entity0 with @entity3 after RP who initially respond to @entity5 continue to do so at 3 years and are satisfied and compliant with the treatment regimen.

title: Long-term effect of @entity5 on XXXX after radical prostatectomy: 3-year follow-up.

answer: @entity3


abstract: OBJECTIVES: To evaluate the long-term effect and safety of @entity5 for the treatment of @entity3 after radical prostatectomy (RP). METHODS: The study consisted of 91 @entity0 with @entity3 from our institution who received oral @entity5 after RP. We surveyed these @entity0 using a self-administered questionnaire during the first year of @entity5 use to determine treatment satisfaction, @entity0 compliance, and safety. Those who had responded positively to the drug were surveyed again 3 years later (n = 48). @entity5 was prescribed at a dose of 50 mg and increased to 100 mg if needed. Data were collected from a self-administered questionnaire using the abridged five-item version of the International Index of Erectile Function questionnaire, referred to as the Sexual Health Inventory of @entity0 , and the @entity3 Inventory of Treatment Satisfaction. The @entity0 were stratified according to the type of nerve-sparing (NS) RP procedure they underwent: bilateral NS, unilateral NS, and non-NS. RESULTS: At 3 years, 31 (71%) of the 43 @entity0 who had returned the second surveys were still responding to @entity5 . Of these 31 respondents, 10 (31%) had augmented their dose from 50 to 100 mg. The dropout rate was 27%; 6 of 12 had discontinued because of the return of natural erections, 5 because of a loss of efficacy, and 1 because his spouse had died. No differences were found in the 1-year and 3-year five-item International Index of Erectile Function (Sexual Health Inventory of @entity0 ) and @entity3 Inventory of Treatment Satisfaction scores between the NS groups. The most common side effects at 3 years were @entity1 (12%), @entity4 (10%), and @entity2 (2%). No @entity0 discontinued the drug at 3 years because of side effects. CONCLUSIONS: The results of this study indicate that the vast majority of @entity0 with @entity3 after RP who initially respond to @entity5 continue to do so at 3 years and are satisfied and compliant with the treatment regimen.

title: Long-term effect of XXXX on @entity3 after radical prostatectomy: 3-year follow-up.

answer: @entity5


abstract: OBJECTIVES: To determine quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) detection of luteinizing hormone-releasing hormone ( @entity4 ) receptor mRNA expressing @entity2 (CaP) and @entity3 ( @entity3 ) tissue by sequence-specific detection with hybridization probes using the LightCycler. Various in vitro studies have indicated that @entity4 agonists and antagonists may have a direct inhibitory effect on CaP mediated by specific @entity4 receptors. The incidence of @entity4 receptor mRNA expression was demonstrated in 50% to 100% of clinical CaP and @entity3 tissue by current RT-PCR methods. However, qualitative RT-PCR can only demonstrate the existence of a gene; an exact quantification of @entity4 -receptor mRNA expression has not yet been done. METHODS: Quantitative real-time RT-PCR for @entity4 receptor mRNA was performed using the LightCycler system and the RNA Amplification Kit hybridization probes in 35 @entity0 with CaP and 38 @entity0 with @entity3 . RESULTS: Thirty-one (88.6%) of the 35 @entity0 with CaP and 36 (94.7%) of the 38 @entity0 with @entity3 had positive RT-PCR for @entity4 receptor mRNA. The number of positive amplifications per 1 microg total RNA was not significantly lower in CaP at 695,428 +/- 350,860 than in @entity3 at 1,617,654 +/- 787,874. @entity0 with CaP evidenced a significant negative correlation between the amplification rate for @entity4 receptor mRNA and Gleason score (r = -0.476; P = 0.004). CONCLUSIONS: In the past, the potential mechanisms acting on @entity4 receptors in CaP have been identified as possible antitumor strategies for this type of @entity1 . Our study is the first to show that CaP does not have a higher expression of @entity4 receptor mRNA expression than @entity3 when using quantitative sequence-specific oligonucleotide hybridization probes that only detect certain PCR products.

title: Real-time quantitative reverse transcriptase-polymerase chain reaction for luteinizing hormone-releasing hormone receptor gene mRNA expression in @entity0 XXXX .

answer: @entity2


abstract: OBJECTIVES: To determine quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) detection of luteinizing hormone-releasing hormone ( @entity4 ) receptor mRNA expressing @entity2 (CaP) and @entity3 ( @entity3 ) tissue by sequence-specific detection with hybridization probes using the LightCycler. Various in vitro studies have indicated that @entity4 agonists and antagonists may have a direct inhibitory effect on CaP mediated by specific @entity4 receptors. The incidence of @entity4 receptor mRNA expression was demonstrated in 50% to 100% of clinical CaP and @entity3 tissue by current RT-PCR methods. However, qualitative RT-PCR can only demonstrate the existence of a gene; an exact quantification of @entity4 -receptor mRNA expression has not yet been done. METHODS: Quantitative real-time RT-PCR for @entity4 receptor mRNA was performed using the LightCycler system and the RNA Amplification Kit hybridization probes in 35 @entity0 with CaP and 38 @entity0 with @entity3 . RESULTS: Thirty-one (88.6%) of the 35 @entity0 with CaP and 36 (94.7%) of the 38 @entity0 with @entity3 had positive RT-PCR for @entity4 receptor mRNA. The number of positive amplifications per 1 microg total RNA was not significantly lower in CaP at 695,428 +/- 350,860 than in @entity3 at 1,617,654 +/- 787,874. @entity0 with CaP evidenced a significant negative correlation between the amplification rate for @entity4 receptor mRNA and Gleason score (r = -0.476; P = 0.004). CONCLUSIONS: In the past, the potential mechanisms acting on @entity4 receptors in CaP have been identified as possible antitumor strategies for this type of @entity1 . Our study is the first to show that CaP does not have a higher expression of @entity4 receptor mRNA expression than @entity3 when using quantitative sequence-specific oligonucleotide hybridization probes that only detect certain PCR products.

title: Real-time quantitative reverse transcriptase-polymerase chain reaction for luteinizing hormone-releasing hormone receptor gene mRNA expression in XXXX @entity2 .

answer: @entity0


abstract: BACKGROUND: The oncologic outcomes of laparoscopy-assisted gastrectomy (LAG) for the treatment of @entity0 with local advanced @entity1 (AGC) have not been evaluated. This study aimed to validate the oncologic efficacy of LAG for AGC. METHODS: The data from 539 @entity0 who underwent LAG and 539 @entity0 treated with open gastrectomy (OG) were selected using the propensity score-matching method from a database prospectively constructed between 2005 and 2011. The therapeutic value of @entity2 ( @entity2 ) dissection and the long-term surgical outcomes of these matched groups were compared. RESULTS: The groups were well balanced after the propensity score matched. The LAG and OG groups did not differ significantly in terms of clinicopathologic characteristics. The number of dissected LNs at stations 11 and 12a were significantly higher in the LAG group. However, the therapeutic index at each @entity2 station did not differ significantly between the two groups. Although the overall survival curve at each stage did not differ significantly (P  >  0.05), the survival rate increased overall for @entity0 with pT4aN3bM0 in the OG group (P  <  0.05). The stratified analysis showed that overall survival was inferior for LAG surgeons with fewer than 40 completed cases. The survival results for surgeons who had performed more than 40 cases were similar to the results from open surgery. CONCLUSIONS: Although LAG yields comparable oncologic outcomes for local AGC, @entity0 with pT4aN3bM0 @entity1 may not be suitable for laparoscopic surgery, especially for surgeons with limited experience.

title: Is All Advanced XXXX Suitable for Laparoscopy-Assisted Gastrectomy With Extended Lymphadenectomy? A Case-Control Study Using a Propensity Score Method.

answer: @entity1


abstract: RATIONALE: @entity2 may produce a variety of autonomic alterations. These alterations may occur due to evoked autonomic reflexes or as a direct cortical effect on autonomic control. In animal studies, lock step phenomena of interictal discharges to autonomic output have been repeatedly documented. However, the association of interictal discharges and autonomic output is not as well established in @entity0 . METHODS: RR intervals timely locked to @entity1 (RR(n)) were compared to RR intervals immediately following (RR(n+1)) interictal discharges in 40 @entity0 with focal onset @entity1 and low baseline heart beat variability. RESULTS: In 20 @entity0 with 200 left sided @entity1 , RR(n) shortened in 100 and prolonged in 31 when compared to RR(n+1) intervals. While in 20 @entity0 with 200 right sided @entity1 RR(n) intervals shortened in 17 and prolonged in 116 (Chi square P<0.001). No consistent differences in RR(n) intervals variability between frontal versus temporal localization of the interictal discharges from the same side was found. CONCLUSIONS: Interictal discharges, may influence autonomic control over the cardiac cycle and agree with animal studies. Further study of the relationship of interictal discharges to autonomic output is needed to delineate the potential lateralized influences over autonomic nervous system.

title: Heart rate variability during XXXX .

answer: @entity1


abstract: Granule cells with @entity6 ( @entity6 ) are found after @entity1 ( @entity1 ) in three @entity0 models of @entity4 . These granule cells are commonly located at the hilar border and could be newly born granule cells based on their location. The aim of this study was to determine how long it takes for @entity6 to form on granule cells after @entity1 . @entity5 was injected to induce @entity1 and @entity0 were killed at different times: 3 days, 1, 2, and 3 weeks after @entity1 . Biocytin was injected into @entity3 stratum lucidum of hippocampal slices to label granule cells with @entity6 . The number, morphology, and length of @entity6 were analyzed at the different time points. Basal processes of granule cells from @entity0 killed 3 days after @entity5 injection were judged not to be @entity6 because they were short in length and did not ramify in the hilus. "True" @entity6 were detected as early as 7 and 8 days after @entity5 -induced @entity1 . Similar frequencies of granule cells with @entity6 were observed at the later time points. This study shows that @entity6 can form on granule cells as early as 1 week following @entity1 . These results are consistent with the hypothesis that @entity6 on granule cells may be generated from @entity2 -induced, de novo granule cells, however, alternative explanations that some or all @entity6 arise from pre- @entity1 generated granule cells cannot be ruled out at this time and will require further examination.

title: Temporal profile of hilar basal dendrite formation on dentate granule cells after XXXX .

answer: @entity1


abstract: UNASSIGNED: There is no consensus on a diagnostic strategy for @entity6 underlying @entity7 . We conducted a prospective study to assess the accuracy of multiple bone biopsies and imaging to diagnose pelvic @entity6 . @entity0 with clinically suspected @entity6 beneath pelvic @entity7 were enrolled. Bone magnetic resonance imaging (MRI) and surgical bone biopsies (three or more for microbiology and one for histology per @entity4 ) were performed. @entity5 diagnosis relied upon the association of positive histology and microbiology (at least one positive culture for non-commensal microorganisms or three or more for commensal microorganisms of the skin). From 2011 to 2014, 34 @entity0 with 44 @entity7 were included. @entity5 was diagnosed for 28 (82.3%) @entity0 and 35 (79.5%) @entity4 according to the composite criterion. Discrepancy was observed between histology and microbiology for 5 (11.4%) @entity4 . Most common isolates were @entity1 (77.1%), Peptostreptococcus (48.6%) and Bacteroides (40%), cultured in three or more samples in 42.9% of @entity4 for @entity1 and >= 20% for anaerobes. Only 2.8% of @entity4 had three or more positive specimens with coagulase-negative staphylococci, group B Streptococcus, and nil with enterococci and @entity3 . @entity1 , @entity2 and group milleri Streptococcus were recovered from one sample in 22.8%, 11.4% and 11.4% of @entity4 , respectively. Agreement was poor between biopsies and MRI (k 0.2). Sensitivity of MRI was 94.3% and specificity was 22.2%. The diagnosis of pelvic @entity6 relies on multiple surgical bone biopsies with microbiological and histological analyses. At least three bone samples allows the detection of pathogens and exclusion of contaminants. MRI is not routinely useful for diagnosis.

title: Diagnosing pelvic XXXX in spinal cord injured @entity0 : a prospective study.

answer: @entity7


abstract: UNASSIGNED: There is no consensus on a diagnostic strategy for @entity6 underlying @entity7 . We conducted a prospective study to assess the accuracy of multiple bone biopsies and imaging to diagnose pelvic @entity6 . @entity0 with clinically suspected @entity6 beneath pelvic @entity7 were enrolled. Bone magnetic resonance imaging (MRI) and surgical bone biopsies (three or more for microbiology and one for histology per @entity4 ) were performed. @entity5 diagnosis relied upon the association of positive histology and microbiology (at least one positive culture for non-commensal microorganisms or three or more for commensal microorganisms of the skin). From 2011 to 2014, 34 @entity0 with 44 @entity7 were included. @entity5 was diagnosed for 28 (82.3%) @entity0 and 35 (79.5%) @entity4 according to the composite criterion. Discrepancy was observed between histology and microbiology for 5 (11.4%) @entity4 . Most common isolates were @entity1 (77.1%), Peptostreptococcus (48.6%) and Bacteroides (40%), cultured in three or more samples in 42.9% of @entity4 for @entity1 and >= 20% for anaerobes. Only 2.8% of @entity4 had three or more positive specimens with coagulase-negative staphylococci, group B Streptococcus, and nil with enterococci and @entity3 . @entity1 , @entity2 and group milleri Streptococcus were recovered from one sample in 22.8%, 11.4% and 11.4% of @entity4 , respectively. Agreement was poor between biopsies and MRI (k 0.2). Sensitivity of MRI was 94.3% and specificity was 22.2%. The diagnosis of pelvic @entity6 relies on multiple surgical bone biopsies with microbiological and histological analyses. At least three bone samples allows the detection of pathogens and exclusion of contaminants. MRI is not routinely useful for diagnosis.

title: Diagnosing pelvic @entity7 in spinal cord injured XXXX : a prospective study.

answer: @entity0


abstract: Phonatory dysfunction is a frequent component of @entity9 and often is a primary feature noted in clinical assessment. But the @entity2 can be difficult to assess because (a). the analysis of @entity8 of any kind can be challenging, and (b). the @entity8 in @entity9 often occurs along with other impairments affecting articulation, resonance, and respiration. A promising assessment tool is multi-parameter acoustic analysis, such as the Multi-Dimensional Voice Program (MDVP). Part 1 of this paper recommends procedures and standards for the acoustic analysis of voice, including (1). selection of the sample to be analyzed, (2). signal quality requirements, (3). availability of normative data for both genders and different ages of speakers, (4). reliability of analysis, and (5). correlation of acoustic results with results from other methods of analysis. In Part 2, acoustic data are reviewed for the @entity9 associated with @entity5 ( @entity5 ), @entity3 , @entity7 ( @entity7 ), @entity4 ( @entity4 ), unilateral @entity1 , and essential @entity6 . Tentative profiles of @entity8 are described for these conditions. These profiles may serve as hypotheses for future research. Although several issues remain to be resolved in the acoustic analysis of @entity8 in @entity9 , steps can be taken now to promote the reliability, validity, and clinical utility of such analyses. (1). As a result of this activity, the @entity0 will be able to describe ways in which an optimal multi-dimensional analysis of voice can be performed with modern acoustic analysis systems. (2). As a result of this activity, the @entity0 will be able to apply multi-dimensional acoustic analysis of voice to individuals who have a @entity9 -related @entity8 . (3). As a result of this activity, the @entity0 will be able to identify major sources of normative data on the Multi-Dimensional Voice Program.

title: Voice dysfunction in XXXX : application of the Multi-Dimensional Voice Program.

answer: @entity9


abstract: PURPOSE: Conservative breast surgery (CBS) is viewed as a surgical technique able to improve the psychophysical outcome of @entity1 who underwent surgery for @entity0 ( @entity0 ). CBS has clearly improved the impact of local treatment on postoperative body image adjustment, but the effect on @entity1 ' quality of life (QL) is similar to that observed after mastectomy. This insufficient adjustment may be related to the fact that sensorial alterations, mainly @entity3 , may produce negative effects on @entity1 ' QL. This retrospective study, based on self-completed questionnaires, reports the @entity1 ' descriptions of @entity3 and its relationships with QL adjustment after quadrantectomy and radiotherapy for @entity0 . @entity1 AND METHODS: We mailed a questionnaire to a consecutive series of 481 @entity1 treated with CBS and radiotherapy from March 1995 to March 1998. The questionnaire, listing 129 items, comprised: (1) a @entity3 assessment module with the short form of the McGill @entity3 Questionnaire exploring the characteristics and the description of the @entity3 ; (2) a QL questionnaire including four subscales (physical well-being, psychological well-being, physical autonomy, and relationships). RESULTS: Three hundred and forty-eight @entity1 (72%) completed the questionnaire, but 24 were excluded from the analysis due to absence of axillary dissection. One hundred and forty-one @entity1 reported @entity3 as a consequence of treatment. It generally started within 3 months after the completion of therapy, was localized in the axillary region and was intermittent. The @entity3 was mainly described as aching (59%), tender (51%) and cramping (43%). Compared to the @entity1 who did not experience @entity3 , those who suffered from @entity3 had significantly worse scores in physical (p < 0.0001), psychological (p < 0.0001), autonomy (p < 0.05), and relational subscales (p < 0.0001). CONCLUSIONS: Our data support the hypothesis that @entity3 is a frequent sequela of CBS and radiotherapy, and that such symptoms can cause @entity2 , thus limiting @entity1 adaptation and reducing the beneficial effect of CBS on body image.

title: @entity3 after quadrantectomy and radiotherapy for XXXX : incidence, characteristics and influence on quality of life. Results from a retrospective study.

answer: @entity0