abstract: The timing of surgery in @entity0 with severe @entity1 and left ventricular (LV) failure, particularly when associated with active @entity4 ( @entity4 ), is of the utmost importance. From July 1982 to May 1984, 34 @entity0 , aged 15 to 60 years, with severe @entity1 underwent immediate (within 24 hours of diagnosis) aortic valve surgery. All @entity0 were in New York Heart Association class IV for LV failure. Eighteen @entity0 had @entity3 . Decision for immediate surgery was based on the echocardiographic demonstration of diastolic closure of the mitral valve or of vegetations on the aortic valve. Premature closure of the mitral valve was demonstrated echocardiographically in 17 @entity0 , 13 of whom had diastolic crossover of LV and left atrial pressure tracings recorded at surgery. @entity4 of the aortic valve was confirmed at surgery in 29 @entity0 , 27 of whom had vegetations on echocardiography. Seven @entity0 required replacement of both aortic and mitral valves. Antibiotic therapy for @entity4 was started immediately after blood cultures were taken and continued for 4 to 6 weeks postoperatively. The mortality rate within 30 days of surgery was 6% for the group as a whole and 7% for those with @entity4 . Mean follow-up period for the 32 survivors was 10.6 months. There were 2 late deaths. No @entity0 had @entity2 or persistence of @entity4 . Procrastination in referral for surgery of these extremely ill @entity0 is not justified and is likely to be associated with higher risks of morbidity and mortality.

title: Contribution of echocardiography and immediate surgery to the management of severe XXXX from active @entity4 .

answer: @entity1


abstract: The timing of surgery in @entity0 with severe @entity1 and left ventricular (LV) failure, particularly when associated with active @entity4 ( @entity4 ), is of the utmost importance. From July 1982 to May 1984, 34 @entity0 , aged 15 to 60 years, with severe @entity1 underwent immediate (within 24 hours of diagnosis) aortic valve surgery. All @entity0 were in New York Heart Association class IV for LV failure. Eighteen @entity0 had @entity3 . Decision for immediate surgery was based on the echocardiographic demonstration of diastolic closure of the mitral valve or of vegetations on the aortic valve. Premature closure of the mitral valve was demonstrated echocardiographically in 17 @entity0 , 13 of whom had diastolic crossover of LV and left atrial pressure tracings recorded at surgery. @entity4 of the aortic valve was confirmed at surgery in 29 @entity0 , 27 of whom had vegetations on echocardiography. Seven @entity0 required replacement of both aortic and mitral valves. Antibiotic therapy for @entity4 was started immediately after blood cultures were taken and continued for 4 to 6 weeks postoperatively. The mortality rate within 30 days of surgery was 6% for the group as a whole and 7% for those with @entity4 . Mean follow-up period for the 32 survivors was 10.6 months. There were 2 late deaths. No @entity0 had @entity2 or persistence of @entity4 . Procrastination in referral for surgery of these extremely ill @entity0 is not justified and is likely to be associated with higher risks of morbidity and mortality.

title: Contribution of echocardiography and immediate surgery to the management of severe @entity1 from active XXXX .

answer: @entity4


abstract: Nuclear orphan receptors 4A (NR4A) are early responsive genes that belong to the superfamily of hormone receptors and comprise @entity5 , @entity10 and @entity12 . They have been associated to transcriptional activation of multiple genes involved in @entity1 , apoptosis and cell cycle control. Here, we establish a link between NR4As and @entity2 , a paradoxical inflammatory molecule that can contribute to persistence of @entity1 or mediate inflammatory shutdown. Transcriptomics screening of the @entity0 mast cell-line HMC-1 revealed a sharp induction of transcriptionally active @entity10 and @entity12 by the @entity2 analogue @entity11 . The concomitant treatment of NECA and the @entity2 receptor A(2A) (A(2A)AR) selective antagonist @entity7 exaggerated this effect, suggesting that upregulation of these factors in mast cells is mediated by other AR subtypes (A(2B) and A(3)) and that A(2A)AR activation counteracts @entity10 and @entity12 induction. In agreement with this, A(2A)AR-silencing amplified NR4A induction by NECA. Interestingly, a similar A(2A)AR modulatory effect was observed on @entity3 phosphorylation because A(2A)AR blockage exacerbated NECA-mediated phosphorylation of @entity3 . In addition, @entity6 or @entity9 inhibition prevented @entity3 phosphorylation and antagonized AR-mediated induction of @entity10 and @entity12 , suggesting the involvement of these kinases in AR to NR4A signaling. Finally, we observed that selective A(2A)AR activation with @entity8 blocked @entity4 -induced @entity3 phosphorylation and modulated the overexpression of functional nuclear orphan receptors 4A. Taken together, these results establish a novel @entity6 /ERK/nuclear orphan receptors 4A axis for adenosinergic signaling in mast cells, which can be modulated by A(2A)AR activation, not only in the context of @entity2 but of other mast cell activating stimuli as well.

title: Selective regulation of nuclear orphan receptors 4A by XXXX receptor subtypes in @entity0 mast cells.

answer: @entity2


abstract: Nuclear orphan receptors 4A (NR4A) are early responsive genes that belong to the superfamily of hormone receptors and comprise @entity5 , @entity10 and @entity12 . They have been associated to transcriptional activation of multiple genes involved in @entity1 , apoptosis and cell cycle control. Here, we establish a link between NR4As and @entity2 , a paradoxical inflammatory molecule that can contribute to persistence of @entity1 or mediate inflammatory shutdown. Transcriptomics screening of the @entity0 mast cell-line HMC-1 revealed a sharp induction of transcriptionally active @entity10 and @entity12 by the @entity2 analogue @entity11 . The concomitant treatment of NECA and the @entity2 receptor A(2A) (A(2A)AR) selective antagonist @entity7 exaggerated this effect, suggesting that upregulation of these factors in mast cells is mediated by other AR subtypes (A(2B) and A(3)) and that A(2A)AR activation counteracts @entity10 and @entity12 induction. In agreement with this, A(2A)AR-silencing amplified NR4A induction by NECA. Interestingly, a similar A(2A)AR modulatory effect was observed on @entity3 phosphorylation because A(2A)AR blockage exacerbated NECA-mediated phosphorylation of @entity3 . In addition, @entity6 or @entity9 inhibition prevented @entity3 phosphorylation and antagonized AR-mediated induction of @entity10 and @entity12 , suggesting the involvement of these kinases in AR to NR4A signaling. Finally, we observed that selective A(2A)AR activation with @entity8 blocked @entity4 -induced @entity3 phosphorylation and modulated the overexpression of functional nuclear orphan receptors 4A. Taken together, these results establish a novel @entity6 /ERK/nuclear orphan receptors 4A axis for adenosinergic signaling in mast cells, which can be modulated by A(2A)AR activation, not only in the context of @entity2 but of other mast cell activating stimuli as well.

title: Selective regulation of nuclear orphan receptors 4A by @entity2 receptor subtypes in XXXX mast cells.

answer: @entity0


abstract: UNASSIGNED: Purpose To investigate the diagnostic accuracy of an image-based classifier to distinguish between @entity2 ( @entity2 ) and @entity1 ( @entity1 ) in individual @entity0 by using gray matter (GM) density maps computed from standard T1-weighted structural images obtained with multiple imagers and with independent training and prediction data. Materials and Methods The local institutional review board approved the study. Eighty-four @entity0 with @entity2 , 51 @entity0 with @entity1 , and 94 control subjects were divided into independent training (n = 115) and prediction (n = 114) sets with identical diagnosis and imager type distributions. Training of a support vector machine (SVM) classifier used diagnostic status and GM density maps and produced voxelwise discrimination maps. Discriminant function analysis was used to estimate suitability of the extracted weights for single-subject classification in the prediction set. Receiver operating characteristic (ROC) curves and area under the ROC curve (AUC) were calculated for image-based classifiers and neuropsychological z scores. Results Training accuracy of the SVM was 85% for @entity0 with @entity2 versus control subjects, 72% for @entity0 with @entity1 versus control subjects, and 79% for @entity0 with @entity2 versus @entity0 with @entity1 (P  <= .029). Single-subject diagnosis in the prediction set when using the discrimination maps yielded accuracies of 88% for @entity0 with @entity2 versus control subjects, 85% for @entity0 with @entity1 versus control subjects, and 82% for @entity0 with @entity2 versus @entity0 with @entity1 , with a good to excellent AUC (range, 0.81-0.95; P  <= .001). Machine learning-based categorization of @entity2 versus @entity1 based on GM density maps outperforms classification based on neuropsychological test results. Conclusion The SVM can be used in single-subject discrimination and can help the clinician arrive at a diagnosis. The SVM can be used to distinguish disease-specific GM patterns in @entity0 with @entity2 and those with @entity1 as compared with normal aging by using common T1-weighted structural MR imaging. (  ) RSNA, 2015.

title: XXXX and @entity1 : Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis.

answer: @entity2


abstract: UNASSIGNED: Purpose To investigate the diagnostic accuracy of an image-based classifier to distinguish between @entity2 ( @entity2 ) and @entity1 ( @entity1 ) in individual @entity0 by using gray matter (GM) density maps computed from standard T1-weighted structural images obtained with multiple imagers and with independent training and prediction data. Materials and Methods The local institutional review board approved the study. Eighty-four @entity0 with @entity2 , 51 @entity0 with @entity1 , and 94 control subjects were divided into independent training (n = 115) and prediction (n = 114) sets with identical diagnosis and imager type distributions. Training of a support vector machine (SVM) classifier used diagnostic status and GM density maps and produced voxelwise discrimination maps. Discriminant function analysis was used to estimate suitability of the extracted weights for single-subject classification in the prediction set. Receiver operating characteristic (ROC) curves and area under the ROC curve (AUC) were calculated for image-based classifiers and neuropsychological z scores. Results Training accuracy of the SVM was 85% for @entity0 with @entity2 versus control subjects, 72% for @entity0 with @entity1 versus control subjects, and 79% for @entity0 with @entity2 versus @entity0 with @entity1 (P  <= .029). Single-subject diagnosis in the prediction set when using the discrimination maps yielded accuracies of 88% for @entity0 with @entity2 versus control subjects, 85% for @entity0 with @entity1 versus control subjects, and 82% for @entity0 with @entity2 versus @entity0 with @entity1 , with a good to excellent AUC (range, 0.81-0.95; P  <= .001). Machine learning-based categorization of @entity2 versus @entity1 based on GM density maps outperforms classification based on neuropsychological test results. Conclusion The SVM can be used in single-subject discrimination and can help the clinician arrive at a diagnosis. The SVM can be used to distinguish disease-specific GM patterns in @entity0 with @entity2 and those with @entity1 as compared with normal aging by using common T1-weighted structural MR imaging. (  ) RSNA, 2015.

title: @entity2 and XXXX : Automatic Classification Based on Cortical Atrophy for Single-Subject Diagnosis.

answer: @entity1


abstract: INTRODUCTION: We studied variables associated with outcomes following intestinal resection for @entity1 . METHODS: A retrospective review of a prospectively maintained single surgeon database was performed. Outcomes evaluated included disease recurrence, need for further resection/dilatation, and complications. Explanatory variables included: anatomical region of resection, open or laparoscopic approach, surgical procedure, technique of @entity2 , number of anastomoses, use of biological therapy, resection margin disease, age at resection, and period (quartile) in series. RESULTS: 81 @entity0 had 100 resections at a median age 14.5years with a median follow-up of 7.7years. Overall complication rate was 22%. Of the 77 @entity0 with no prior resection, 40 (52%) had disease recurrence, and 24 (31%) underwent further resection or dilatation. None of the explanatory variables predicted complications. Disease recurrence was significantly associated with younger age at first resection but not duration of follow-up. The probability of further intestinal intervention was strongly associated with disease site and complications. Odds ratio for further surgery for colonic disease site compared to ileocecal disease site was 7 (95% CI 1.8-26; P=0.004). Odds ratio for further intestinal resection following surgery where a complication had occurred compared to no complication was 3.4 (95% CI 1.1-10.3; P=0.02. Both disease site and complication status also significantly affected the interval to further surgery. CONCLUSIONS: The probability of requiring a second intestinal intervention for pediatric @entity1 is related to the disease site and the complication status.

title: Colonic disease site and perioperative complications predict need for later intestinal interventions following intestinal resection in pediatric XXXX .

answer: @entity1


abstract: OBJECTIVE: To study the effectiveness and safety of the laparoscopic ileal bladder augmentation treatment for @entity9 . METHODS: A retrospective analysis was performed based on 36 cases admitted to the Zhejiang Provincial @entity0 's Hospital with highly reflective and @entity9 accepted laparoscopic ileal bladder augmentation surgical treatment from June 2011 to December 2013. In accordance with inclusion and exclusion criteria, 22 @entity0 were enrolled in this study, including 13 males, 9 females who aged from 22 to 62 years with an average of 35.8 years. Among the selected sample, there were 15 cases of @entity10 , 4 cases of @entity6 , and 3 cases of @entity4 . The duration of disease varied from 1 to 15 years, with an average of 8.5 years. For surgery, intraoperative and perioperative complications were observed, and preoperative serum @entity7 in @entity0 with postoperative at 3, 6, 12, 18, 24, 36 months, @entity11 , and glomerular filtration rate urodynamic parameters were used for univariate analysis of variance. RESULTS: All @entity0 were successfully completed in laparoscopic surgery, the operative time were (105    17) minutes (90-150 minutes), @entity2 was (90    26) ml (60-150 ml), postoperative intestinal function recovery time were (2.5    0.7) d (2-5 d), and postoperative hospital stay was (15.0    4.2) d (11-20 d), while postoperative anastomotic leakage, intestinal blockage, severe @entity8 or @entity3 and other complications did not occur. @entity0 were followed up for 6 to 36 months, with an average of 16.5 months, among which 17 @entity0 were followed up for over 12 months. The bladder safety capacity increased from (103    38) ml preoperatively to (405    46) ml at the end of the follow-up (F = 381.7, P = 0.000), and bladder compliance increased from (10    3) cm @entity12 (1 cmH2O = 0.098 kPa) preoperatively to (38    4) @entity13 O (F = 678.1, P = 0.000); the average pressure within the bladder filling at the end of the follow-up was (16    6) cm @entity12 , which was significantly lower (F = 221.5, P = 0.000) compared to preoperative level of (45    16) cm @entity12 , preoperative serum @entity7 went down from (184    32)   mol/L to (120    28)   mol/L at the end of the follow-up (F = 189.1, P = 0.000); total glomerular filtration rate rose from (40    26) ml(-1)    min(-1)    1.73 m(-2) preoperatively to (66    32) ml(-1)    min(-1)    1.73 m(-2) (F = 137.7, P = 0.000). Qmax of the 3 cases of @entity9 contracture @entity4 @entity0 increased significantly, while 4 female @entity0 with residual urine volume decrease had voluntary urination. CONCLUSIONS: Laparoscopic ileal bladder augmentation treatment for @entity9 is feasible and safe, with less @entity1 , less @entity5 , less post-operative complications, and faster recovery of bowel function. Urinary function improves significantly after surgery, and function of upper urinary tract can also be effectively improved and protected in @entity0 .

title: [The preliminary clinical results of laparoscopic ileum augmentation cystoplasty for XXXX ].

answer: @entity9


abstract: Background. @entity7 is a fibrotic enlargement of the gingiva. It may exist as an @entity2 or as @entity6 . This paper reports a case of 16-year-old male with generalized severe @entity5 , involving the maxillary and mandibular arches and covering almost all teeth. Methods. Periodontal management of @entity3 included gingivectomy in both arches except in the lower right molar region where flap surgery was done under general anesthesia. After a 2-month followup period, orthodontic treatment was started with fixed appliances. Monthly periodontal checkups and maintainance (scaling and polishing) were scheduled to control the @entity1 . Results. Reevaluation of the @entity0 of surgical treatment after two months did not show any recurrence of condition; however, minimal overgrowth was noted 1 month after the beginning of orthodontic treatment which was treated nonsurgically. Conclusions. Although the risk of recurrence is high with this condition, surgical treatment with correction of @entity4 and regular followup can provide excellent outcome as seen in this case.

title: Multispeciality approach in the management of @entity0 with XXXX : 1-year followup: a case report.

answer: @entity7


abstract: Background. @entity7 is a fibrotic enlargement of the gingiva. It may exist as an @entity2 or as @entity6 . This paper reports a case of 16-year-old male with generalized severe @entity5 , involving the maxillary and mandibular arches and covering almost all teeth. Methods. Periodontal management of @entity3 included gingivectomy in both arches except in the lower right molar region where flap surgery was done under general anesthesia. After a 2-month followup period, orthodontic treatment was started with fixed appliances. Monthly periodontal checkups and maintainance (scaling and polishing) were scheduled to control the @entity1 . Results. Reevaluation of the @entity0 of surgical treatment after two months did not show any recurrence of condition; however, minimal overgrowth was noted 1 month after the beginning of orthodontic treatment which was treated nonsurgically. Conclusions. Although the risk of recurrence is high with this condition, surgical treatment with correction of @entity4 and regular followup can provide excellent outcome as seen in this case.

title: Multispeciality approach in the management of XXXX with @entity7 : 1-year followup: a case report.

answer: @entity0


abstract: @entity5 is an antiarrhythmic agent known to cause prolongation of action potential duration which is reflected in the electrocardiogram as a prolongation of the QT interval. @entity2 in @entity0 dying suddenly was compared with that in @entity0 who remained alive to determine whether a difference existed between these two groups. The electrocardiogram and @entity5 levels were evaluated in 33 @entity0 who presented with @entity4 and symptomatic @entity3 in whom no other antiarrhythmic agent was found effective in preventing induction of @entity3 during electrophysiologic studies. There were 30 @entity0 and 3 @entity0 (mean age 52 +/- 10 years). Twenty-three are alive after a mean follow-up period of 12 +/- 7 months. Ten died: six suddenly, three of non-cardiac causes and one of @entity1 . Using a two-way analysis of variance, the percent change in QT, QTc, JT and JTc intervals before and after @entity5 therapy was analyzed. Marked prolongation in the QT interval was present in @entity0 who remained alive with @entity5 therapy. A significant difference in percent @entity2 was seen between the latter @entity0 and those who died suddenly (p less than 0.005). No difference was observed in the percent change in QRS interval between the two groups. The levels of @entity5 (2.5 versus 3.2 micrograms/ml) and its metabolite ( @entity6 ) were not significantly different between the living @entity0 and those who died suddenly. These findings suggest that a prolongation of the QT interval may be a marker for the therapeutic antiarrhythmic effect of @entity5 .

title: @entity2 and the antiarrhythmic efficacy of XXXX .

answer: @entity5


abstract: @entity5 is an antiarrhythmic agent known to cause prolongation of action potential duration which is reflected in the electrocardiogram as a prolongation of the QT interval. @entity2 in @entity0 dying suddenly was compared with that in @entity0 who remained alive to determine whether a difference existed between these two groups. The electrocardiogram and @entity5 levels were evaluated in 33 @entity0 who presented with @entity4 and symptomatic @entity3 in whom no other antiarrhythmic agent was found effective in preventing induction of @entity3 during electrophysiologic studies. There were 30 @entity0 and 3 @entity0 (mean age 52 +/- 10 years). Twenty-three are alive after a mean follow-up period of 12 +/- 7 months. Ten died: six suddenly, three of non-cardiac causes and one of @entity1 . Using a two-way analysis of variance, the percent change in QT, QTc, JT and JTc intervals before and after @entity5 therapy was analyzed. Marked prolongation in the QT interval was present in @entity0 who remained alive with @entity5 therapy. A significant difference in percent @entity2 was seen between the latter @entity0 and those who died suddenly (p less than 0.005). No difference was observed in the percent change in QRS interval between the two groups. The levels of @entity5 (2.5 versus 3.2 micrograms/ml) and its metabolite ( @entity6 ) were not significantly different between the living @entity0 and those who died suddenly. These findings suggest that a prolongation of the QT interval may be a marker for the therapeutic antiarrhythmic effect of @entity5 .

title: XXXX and the antiarrhythmic efficacy of @entity5 .

answer: @entity2


abstract: In situ hybridization provides a method for identifying cells that contain specific nucleic acid sequences. This report outlines an in situ hybridization procedure for @entity0 neural tissue. The method maintains morphological quality and produces excellent specificity. Seven tritiated nucleic acid probes were examined: two ribosomal RNA probes, a control pBR322 plasmid probe, two probes encoding portions of the gene for @entity2 , one probe each encoding a portion of @entity4 glycoprotein, and neurophysin. Using cryostat-cut @entity1 brain sections, rRNA probes labeled the cytoplasm of all cells and the nucleoli of larger neurons. The plasmid probe failed to produce a strong signal. @entity2 and @entity4 probes appropriately labeled the cytoplasm of hypothalamic magnocellular neurons. @entity4 parvocellular neurons were not identified by the current method, and the shorter length neurophysin probe failed to produce a signal. Methodological variables were examined by counting autoradiographic grains in cells. The longer @entity2 probe produced a stronger signal than the shorter @entity2 and @entity4 probes, and higher probe concentrations resulted in stronger signal. Hybridization could be abolished by tissue pretreatment with @entity5 , and longer exposure time increased signal strength. The outlined fixation steps with fresh-frozen tissue produced a superior signal compared to @entity3 -perfused tissue.

title: In situ hybridization technique to localize rRNA and mRNA in XXXX neurons.

answer: @entity0


abstract: UNASSIGNED: Cerebral blood flow, arterial pulsation, and vasomotion play important roles in the transport of waste metabolites out of the brain. Impaired vasomotion results in reduced driving force for the perivascular/glymphatic clearance of beta-amyloid. Noninvasive cerebrovascular characteristic features that potentially assess these transport mechanisms are @entity3 ( @entity3 ) and pulsatility index (PI). In this study, 4D flow MRI was used to measure intra-cranial flow features, particularly @entity3 , PI, resistive index (RI) and cross-sectional area in @entity0 with @entity2 ( @entity2 ), mild @entity1 and in age matched and younger cognitively healthy controls. Three-hundred fourteen subjects participated in this study. Volumetric, time-resolved phase contrast (PC) MRI data were used to quantify hemodynamic parameters from 11 vessel segments. Anatomical variants of the @entity4 were also cataloged. The @entity2 population reported a statistically significant decrease in @entity3 and cross-sectional area, and also an increase in PI and RI compared to age matched cognitively healthy control subjects. The 4D flow MRI technique used in this study provides quantitative measurements of intracranial vessel geometry and the velocity of flow. Cerebrovascular characteristics features of vascular health such as pulsatility index can be extracted from the 4D flow MRI data.

title: 4D flow MRI for intracranial hemodynamics assessment in XXXX .

answer: @entity2


abstract: Peritoneovenous shunts (PVSs) have provided salutary effects on medically recalcitrant @entity11 , functional @entity1 , nutritional derangements, ventilatory embarrassment, and locomotion potential in @entity0 with @entity3 . While the LeVeen (LPVS) and Denver (DPVS) PVSs are most frequently implanted in such @entity0 , @entity5 of @entity8 gastroesophageal varices, @entity6 , and @entity7 occur with notable frequency. Addressing primarily the complication of PVS occlusion, a randomized prospective trial of LPVSs and DPVSs was conducted in cirrhotic @entity0 with refractory @entity11 . From July 1, 1982 to July 1, 1984, 26 initial PVSs were implanted for hepatic-related intractable @entity11 . Twenty-two @entity0 were eligible for randomization ( @entity3 , sterile @entity11 , initial PVS, total @entity10 level less than or equal to 6.0 mg/dL, @entity9 time less than or equal to 5-s prolongation, serum @entity12 level less than or equal to 2.0 mg/dL [ @entity12 clearance rate greater than or equal to 20 mL/min], absence of recent [less than 30 days] @entity8 gastroesophageal varices, or absent spontaneous @entity2 ). Twelve LPVSs and ten DPVSs were implanted; however, one @entity0 with a DPVS was found to have @entity4 and was excluded from analysis. All @entity0 were followed up until death or Jan 1, 1985. The PVS patency determinations included contrast shuntography, technetium Tc 99m albumin scintigraphy, sequential manual compression (DPVS), and operative or autopsy observation. Using the Kaplan-Meier actuarial analysis, the LPVS patency proved to be highly superior to that of the DPVS, while survival was not significantly different. As LPVS and DPVS complications other than patency are comparable, the LPVS is preferred for its superior patency in cirrhotic @entity0 with intractable @entity11 .

title: LeVeen vs Denver peritoneovenous shunts for intractable XXXX of @entity3 . A randomized, prospective trial.

answer: @entity11


abstract: Peritoneovenous shunts (PVSs) have provided salutary effects on medically recalcitrant @entity11 , functional @entity1 , nutritional derangements, ventilatory embarrassment, and locomotion potential in @entity0 with @entity3 . While the LeVeen (LPVS) and Denver (DPVS) PVSs are most frequently implanted in such @entity0 , @entity5 of @entity8 gastroesophageal varices, @entity6 , and @entity7 occur with notable frequency. Addressing primarily the complication of PVS occlusion, a randomized prospective trial of LPVSs and DPVSs was conducted in cirrhotic @entity0 with refractory @entity11 . From July 1, 1982 to July 1, 1984, 26 initial PVSs were implanted for hepatic-related intractable @entity11 . Twenty-two @entity0 were eligible for randomization ( @entity3 , sterile @entity11 , initial PVS, total @entity10 level less than or equal to 6.0 mg/dL, @entity9 time less than or equal to 5-s prolongation, serum @entity12 level less than or equal to 2.0 mg/dL [ @entity12 clearance rate greater than or equal to 20 mL/min], absence of recent [less than 30 days] @entity8 gastroesophageal varices, or absent spontaneous @entity2 ). Twelve LPVSs and ten DPVSs were implanted; however, one @entity0 with a DPVS was found to have @entity4 and was excluded from analysis. All @entity0 were followed up until death or Jan 1, 1985. The PVS patency determinations included contrast shuntography, technetium Tc 99m albumin scintigraphy, sequential manual compression (DPVS), and operative or autopsy observation. Using the Kaplan-Meier actuarial analysis, the LPVS patency proved to be highly superior to that of the DPVS, while survival was not significantly different. As LPVS and DPVS complications other than patency are comparable, the LPVS is preferred for its superior patency in cirrhotic @entity0 with intractable @entity11 .

title: LeVeen vs Denver peritoneovenous shunts for intractable @entity11 of XXXX . A randomized, prospective trial.

answer: @entity3


abstract: OBJECTIVE: To compare the perioperative outcome between the endovascular repair (EVAR) and open surgical repair (OSR) for @entity1 . METHODS: From January 2006 to January 2013, totally 66 @entity0 with @entity1 ( @entity1 ) treated by surgery were retrospectively analyzed in Department of vascular surgery, @entity0 's Liberation Army General Hospital. According to the repair method, all the subjects were divided into EVAR group and OSR group. EVAR group included 40 @entity0 , 30 @entity0 were male, 10 @entity0 were female, aged from 47 to 78 with a mean of (71    7) years. OSR group included 26 @entity0 , 21 @entity0 were male, aged from 45 to 87 with a mean of (72    9) years. The difference of the operation time, the amount of suspended red blood cells, ICU stay time, case fatality rate, adverse event rate and the difference of the two intervention rate were compared between the 2 groups by   (2) test and t test. RESULTS: There were significant differences between the 2 groups in operation time, the amount of suspended red blood cells, ICU stay time, case fatality rate, adverse event rate ((183    44) minutes vs. (384    108) minutes, t = -10.59, P = 0.00; (0.4    0.8) units vs. (1.1    1.8) units, t = -2.19, P = 0.03; (3.0    1.8) d vs. (8.5    5.1) d, t = -6.34, P = 0.00; 20.0% (8/40) vs. 46.2% (12/26),   (2) = 5.10, P = 0.02; 25.0% (10/40) vs. 53.8% (14/26),   (2) = 5.67, P = 0.02). There were no significant differences in frozen plasma quantities and the two intervention rate between the 2 groups (t = -1.98, P = 0.05;   (2) = 0.49, P = 0.48). CONCLUSIONS: EVAR decreases the perioperative mortality and adverse event of @entity1 compared with OSR. More studies are necessary to compare the middle and long-outcome between EVAR and OSR of @entity1 .

title: [Comparative study of perioperative outcome between endovascular repair and open surgical repair for XXXX ].

answer: @entity1


abstract: This report presents an update of the Kevorkian-Reding physician-assisted (or physician-aided) @entity1 to include the ninety-three publicly acknowledged cases as of November 25, 1998. These @entity1 are divided into ten distinct time phases. The following trends emerge. Over two-thirds of the decedents are @entity0 , the ratio of females to males varying widely with phase. The proportion of @entity0 seems to be the highest when Kevorkian is free to act as he wants and lowest when he seems to be acting under legal or political restraints. Based on autopsy results, only 29.0 percent of the cases are terminal, this percentage being higher among @entity0 (37.9%) than among @entity0 (25.4%). However, 66.7% of the decedents were disabled, no significant difference emerging between @entity0 and @entity0 . Further, five out of the six decedents showing no apparent anatomical sign of disease at autopsy were @entity0 . Over 80 percent of the physician-assisted @entity1 are cremated, approximately twice as high a proportion as that emerging for suicides in Michigan and four times as high as cremations occurring with regard to overall @entity1 . Finally, @entity1 by @entity2 decreases dramatically with time phase while the use of the contraption dubbed the "suicide machine" increases, suggesting an increasing routinization over time. Finally, during the ninth and tenth phases, Kevorkian's aims and his own suicidality emerge more clearly involving 1) harvesting organs and 2) threat of starving himself in prison if he is convicted. Phase 10 can be seen as an escalation from assisted @entity1 to overt euthanasia, repeating the same need for a demonstration (Thomas Youk) that was first exhibited in Phase I (Janet Adkins).

title: An update on the Kevorkian-Reding 93 physician-assisted XXXX in Michigan: is Kevorkian a savior, serial-killer or suicidal martyr?

answer: @entity1


abstract: OBJECTIVE: This study reports on the efficacy of using the anesthesia simulator to teach sedation and @entity1 to nurses. This provision of sedation and @entity1 to a @entity0 is accomplished with the goal of maintaining the ability of the @entity0 to respond purposefully to auditory or tactile stimuli. METHODS: Nurses working in areas of the hospital where conscious sedation is performed were the @entity0 in this sedation and @entity1 training course. Prior to the training session, the @entity0 read the American Society of Anesthesiology Practice guidelines for sedation and @entity1 by non-anesthesiologists. At the time of the training session, each @entity0 completed a written pretest, had an introduction to sedation and @entity1 with four clinical crisis teaching scenarios using the anesthesia simulator, a practical exam using the simulator, and a written post-test. Each @entity0 was also given the opportunity to complete an evaluation of the session. RESULTS: Twenty nurses completed the training session. The written tests had a maximum possible score of 30. Mean score on the written pretest was 22.9 +/- 3.54, and mean score on the written post-test was 26.0 +/- 4.24 (p < 0.001). Seventeen of the twenty subjects scored higher on the post-test. Mean practical exam score was 5.5 of a possible 6.0. Mean @entity0 rating of the education session was 3.75 (1 = poor, 4 = excellent). All but one @entity0 rated the length of the training session as "about right." CONCLUSIONS: The anesthesia simulator provides an excellent tool for teaching conscious sedation skills to hospital nurses. The @entity0 ' test performance improved following the session, and they also rated the educational experience as excellent.

title: Teaching sedation and XXXX with simulation.

answer: @entity1


abstract: Advancing age is a major risk factor for @entity6 . @entity5 accompanied by increased oxidative stress and @entity1 with aging may predispose older arteries to greater @entity2 -reperfusion (I/R) injury. Because coronary @entity2 cannot be induced safely, the effects of age and habitual endurance exercise on endothelial I/R injury have not been determined in @entity0 . Using the brachial artery as a surrogate model of the coronary arteries, endothelial function, assessed by brachial artery @entity4 ( @entity4 ), was measured before and after 20 min of continuous forearm occlusion in young sedentary (n = 10, 24    2 yr) and middle-aged (n = 9, 48    2 yr) sedentary adults to gain insight into the effects of primary aging on endothelial I/R injury. Young (n = 9, 25    1 yr) and middle-aged endurance-trained (n = 9, 50    2 yr) adults were also studied to determine whether habitual exercise provides protection from I/R injury. Fifteen minutes after @entity2 , @entity4 decreased significantly by 37% in young sedentary, 35% in young endurance-trained, 68% in middle-aged sedentary, and 50% in middle-aged endurance-trained subjects. @entity4 returned to baseline levels within 30 min in young sedentary and endurance-trained subjects but remained @entity3 in middle-aged sedentary and endurance-trained subjects. Circulating markers of antioxidant capacity and @entity1 were not related to @entity4 . In conclusion, advancing age is associated with a greater magnitude and delayed recovery from endothelial I/R injury in @entity0 . Habitual endurance exercise may provide partial protection to the endothelium against this form of I/R injury with advancing age.

title: Endothelial XXXX -reperfusion injury in @entity0 : association with age and habitual exercise.

answer: @entity2


abstract: Advancing age is a major risk factor for @entity6 . @entity5 accompanied by increased oxidative stress and @entity1 with aging may predispose older arteries to greater @entity2 -reperfusion (I/R) injury. Because coronary @entity2 cannot be induced safely, the effects of age and habitual endurance exercise on endothelial I/R injury have not been determined in @entity0 . Using the brachial artery as a surrogate model of the coronary arteries, endothelial function, assessed by brachial artery @entity4 ( @entity4 ), was measured before and after 20 min of continuous forearm occlusion in young sedentary (n = 10, 24    2 yr) and middle-aged (n = 9, 48    2 yr) sedentary adults to gain insight into the effects of primary aging on endothelial I/R injury. Young (n = 9, 25    1 yr) and middle-aged endurance-trained (n = 9, 50    2 yr) adults were also studied to determine whether habitual exercise provides protection from I/R injury. Fifteen minutes after @entity2 , @entity4 decreased significantly by 37% in young sedentary, 35% in young endurance-trained, 68% in middle-aged sedentary, and 50% in middle-aged endurance-trained subjects. @entity4 returned to baseline levels within 30 min in young sedentary and endurance-trained subjects but remained @entity3 in middle-aged sedentary and endurance-trained subjects. Circulating markers of antioxidant capacity and @entity1 were not related to @entity4 . In conclusion, advancing age is associated with a greater magnitude and delayed recovery from endothelial I/R injury in @entity0 . Habitual endurance exercise may provide partial protection to the endothelium against this form of I/R injury with advancing age.

title: Endothelial @entity2 -reperfusion injury in XXXX : association with age and habitual exercise.

answer: @entity0


abstract: Submergence and drought are major constraints to @entity1 ( @entity1 ) production in rain-fed farmlands, both of which can occur sequentially during a single crop cycle. SUB1A, an ERF transcription factor found in limited @entity1 accessions, dampens @entity3 production and @entity5 responsiveness during submergence, economizing @entity2 reserves and significantly prolonging endurance. Here, we evaluated the functional role of SUB1A in acclimation to @entity4 . Comparative analysis of genotypes with and without SUB1A revealed that SUB1A enhanced recovery from drought at the vegetative stage through reduction of leaf water loss and lipid peroxidation and increased expression of genes associated with acclimation to @entity4 . Overexpression of SUB1A augmented ABA responsiveness, thereby activating stress-inducible gene expression. Paradoxically, vegetative tissue undergoes @entity4 upon desubmergence even though the soil contains sufficient water, indicating that leaf desiccation occurs in the natural progression of a flooding event. Desubmergence caused the upregulation of gene transcripts associated with acclimation to @entity4 , with higher induction in SUB1A genotypes. SUB1A also restrained accumulation of reactive @entity0 species (ROS) in aerial tissue during drought and desubmergence. Consistently, SUB1A increased the abundance of transcripts encoding ROS scavenging enzymes, resulting in enhanced tolerance to oxidative stress. Therefore, in addition to providing robust submergence tolerance, SUB1A improves survival of rapid @entity4 following desubmergence and water deficit during drought.

title: The submergence tolerance regulator SUB1A mediates crosstalk between submergence and drought tolerance in XXXX .

answer: @entity1


abstract: Following cutaneous @entity4 regenerate into the dermis and epidermis. Tissues that are innervated by sensory nerves synthesize neurotrophins such as nerve growth factor (NGF). The close anatomic proximity of nerves and capillaries throughout the skin suggests that mutual regulation may exist between nerve fibers and microvascular endothelial cells (MECs) during wound repair. Release of the neuropeptide @entity3 by sensory nerves induces endothelial cell rounding, capillary leak, and cytokine upregulation. We propose that dermal endothelial cells produce neurotrophins required for nerve fiber maintenance and regeneration. In this study, we demonstrate that @entity3 stimulates NGF messenger RNA expression by cultured @entity0 dermal MECs. Likewise, enzyme-linked immunosorbant assay demonstrated that conditioned medium from cultured dermal MECs contains NGF. NGF bioactivity in the supemates was verified by conditioned medium-induced clonal @entity1 @entity2 (PC-12) cell differentiation. This activity was inhibited by anti-NGF antibodies. Therefore, we have demonstrated that @entity3 , an inflammatory neuropeptide released by sensory nerve fibers, induces endothelial cells to produce NGF. Our data suggest that MECs may be unrecognized contributors to nerve regeneration after cutaneous injury.

title: XXXX dermal microvascular endothelial cells produce nerve growth factor: implications for wound repair.

answer: @entity0


abstract: BACKGROUND: Characteristics of the aging face include soft tissue @entity1 , @entity2 resulting in excess facial skin, and gravitational descent or ptosis of facial soft tissues. @entity3 ( @entity4 ) is a synthetic biodegradable polymer that provides soft tissue augmentation through stimulation of an inflammatory tissue response with subsequent collagen deposition. OBJECTIVE: The authors discuss the special considerations inherent in facial aging, describe the mechanism of action and indications for a new @entity4 filler under consideration for Food and Drug Administration (FDA) approval (Sculptra Aesthetic, sanofi-aventis US, Bridgewater, New Jersey), and detail the results of a two-year off-label pilot study with the product. METHODS: The senior author (LAC) treated 106 @entity0 with @entity4 in an off-label indication, as part of a pilot study while Sculptra Aesthetic was being evaluated for FDA approval for cosmetic indications. All @entity0 were followed up for two years to help develop a protocol for injection technique. RESULTS: The age range of @entity0 in this series was 40 to 78 years. Three @entity0 were male and 103 were female. @entity0 received an average injection of 1.6 vials per session, over an average of 2.3 sessions, to achieve volume restoration in the tear trough, midface, malar region, nasolabial folds, prejowl area, mandibular border, and mandibular angle. The authors we achieved 100% follow-up with 99.1% @entity0 satisfaction. The rate of nodule formation was 4.7% at a minimum follow-up of two years. CONCLUSIONS: Because of its unique mechanism of action, @entity4 for nonsurgical facial rejuvenation requires meticulous injection technique with special considerations for optimizing outcomes and minimizing adverse events.

title: Nonsurgical rejuvenation of the aging face with injectable XXXX for restoration of soft tissue volume.

answer: @entity3


abstract: Total hip replacement has become one of the most successful orthopaedic procedures. However, complications due to @entity1 may give serious problems and have devastating consequences for the hip implant. The use of a temporary three-dimensional polymethylmethacrylate ( @entity3 ) cement spacer may be an alternative to solve @entity1 in hip implants, improving the lives of @entity0 awaiting reimplantation. In order to evaluate their wear behaviour, five @entity3 Spacer-G femoral heads were tested against five post-mortem pelves in a hip joint simulator with bovine calf serum as lubricant. The surface of the worn spacers was characterized by scanning electron microscopy (SEM) analysis; all the samples revealed a similar morphology, showing areas characterized by different degrees of wear. Particle debris was isolated from the lubricant and @entity3 particles and bone fractions were quantified. The amount of debris was found to be higher than where no-temporary prostheses were used. However, this result is acceptable since @entity2 is removed by lavage irrigation when the Spacer-G is explanted. On the basis of these data, it is considered that the use of the cement Spacer-G could be a promising approach to the treatment of complicated @entity1 of the hip joint. Therefore, Spacer-G is worthy of further research.

title: Investigations on the wear behaviour of the temporary XXXX -based hip Spacer-G.

answer: @entity3


abstract: INTRODUCTION AND OBJECTIVE: @entity6 ( @entity6 ) is a @entity1 of controversial etiology, affecting some subjects when exposed to chemicals at no harmful concentrations. The objective of this paper is to describe the epidemiological, clinical and psychological features of a sample of @entity0 with @entity6 for further specific group treatment. PATIENS AND METHOD: Descriptive study of @entity0 diagnosed with @entity6 in a toxicology unit. We administered the Quick Environmental Exposure and Sensitivity Inventory, the structured interview @entity4 -II, the @entity2 scale HAS and the type A personality test, PCTA. RESULTS: Seventy-three @entity0 were included. The mean age was 52,6 years (range 33-77; SD 9.29). Sixty-six were females (90.4%). Fifty-three percent were classified as i-ii and ii grade. Sixty-one @entity0 (83%) presented some type of comorbidity, mainly @entity5 , @entity3 and chronic fatigue. They exhibited higher levels of @entity2 (average score of 19.2), prevalence of phobic-avoidant traits of personality and type A behavior in 31.1%. CONCLUSIONS: @entity6 affects middle-aged @entity0 with comorbidities ( @entity5 , @entity3 and chronic fatigue) and high @entity2 and avoidance behaviors. This preliminary analysis should help provide a specific therapeutic approach to these @entity0 .

title: [ XXXX : Clinical evaluation of the severity and psychopathological profile].

answer: @entity6


abstract: OBJECTIVES AND DESIGN: Popliteal vein repair and ligation are the two main approaches to the treatment of the venous component of major, complex, knee injuries with vascular involvement. We have studied the incidence of @entity4 following popliteal vein repair in @entity1 cases using computed tomography (CT) angiography and report the outcome. MATERIAL AND METHODS: From June 2006 to December 2009, 45 @entity0 with @entity1 were operated on in our vascular unit using lateral venorrhaphy, end-to-end @entity2 , a saphenous vein interposition graft and venous patch repair. All the @entity0 were operated on using a medial approach to the knee. On the third postoperative day, all @entity0 underwent a colour Doppler scan of the repaired popliteal vein to study patency, and pulmonary artery CT angiography using a 64-slice multidetector CT scan unit to establish the incidence of @entity4 . RESULTS: The number of @entity0 treated by each method were: lateral venorrhaphy 20 (44%), end-to-end @entity2 13 (29%), saphenous vein interposition graft 9 (20%) and venous patch repair three (7%). Two @entity0 (4%) died because of @entity5 the day after surgery with massive @entity4 at autopsy. Popliteal colour duplex ultrasound imaging showed seven (16%) cases of @entity3 and seven (16%) cases of partial vein @entity3 . CT angiography showed @entity4 in 11 (26%) @entity0 . From seven @entity0 with complete @entity3 three @entity0 , and from seven @entity0 with incomplete @entity3 five @entity0 showed @entity4 on CT angiography. Other than two cases of early mortality, five (12%) @entity0 developed clinical manifestations of @entity4 and 11 (26%) @entity0 had @entity4 detected by CT angiography. Seven (16%) of our @entity0 had mild-to-severe @entity4 and 13 @entity0 (29%) had proven @entity4 . The total mortality rate was 7%. CONCLUSION: A surprisingly high incidence of @entity4 was observed after popliteal vein repair in civil @entity1 @entity0 . Additional prophylactic methods such as using higher doses of heparin and using inferior vena cava (IVC) filters might be needed to prevent this potentially fatal complication.

title: Incidence and outcome of @entity4 following popliteal venous repair in XXXX cases.

answer: @entity1


abstract: OBJECTIVES AND DESIGN: Popliteal vein repair and ligation are the two main approaches to the treatment of the venous component of major, complex, knee injuries with vascular involvement. We have studied the incidence of @entity4 following popliteal vein repair in @entity1 cases using computed tomography (CT) angiography and report the outcome. MATERIAL AND METHODS: From June 2006 to December 2009, 45 @entity0 with @entity1 were operated on in our vascular unit using lateral venorrhaphy, end-to-end @entity2 , a saphenous vein interposition graft and venous patch repair. All the @entity0 were operated on using a medial approach to the knee. On the third postoperative day, all @entity0 underwent a colour Doppler scan of the repaired popliteal vein to study patency, and pulmonary artery CT angiography using a 64-slice multidetector CT scan unit to establish the incidence of @entity4 . RESULTS: The number of @entity0 treated by each method were: lateral venorrhaphy 20 (44%), end-to-end @entity2 13 (29%), saphenous vein interposition graft 9 (20%) and venous patch repair three (7%). Two @entity0 (4%) died because of @entity5 the day after surgery with massive @entity4 at autopsy. Popliteal colour duplex ultrasound imaging showed seven (16%) cases of @entity3 and seven (16%) cases of partial vein @entity3 . CT angiography showed @entity4 in 11 (26%) @entity0 . From seven @entity0 with complete @entity3 three @entity0 , and from seven @entity0 with incomplete @entity3 five @entity0 showed @entity4 on CT angiography. Other than two cases of early mortality, five (12%) @entity0 developed clinical manifestations of @entity4 and 11 (26%) @entity0 had @entity4 detected by CT angiography. Seven (16%) of our @entity0 had mild-to-severe @entity4 and 13 @entity0 (29%) had proven @entity4 . The total mortality rate was 7%. CONCLUSION: A surprisingly high incidence of @entity4 was observed after popliteal vein repair in civil @entity1 @entity0 . Additional prophylactic methods such as using higher doses of heparin and using inferior vena cava (IVC) filters might be needed to prevent this potentially fatal complication.

title: Incidence and outcome of XXXX following popliteal venous repair in @entity1 cases.

answer: @entity4


abstract: BACKGROUND: Lifestyle-related diseases, such as @entity1 and @entity7 are important risk factors for @entity6 ( @entity6 ). However, the underlying mechanism linking these diseases and @entity6 has not been fully investigated. METHODS: Adult male @entity0 were fed a high-fat diet (HFD) or vehicle (NC) for 2months. Electrocardiography and in vivo electrophysiological study were performed. @entity0 were then sacrificed for quantification of mRNA, microRNA, and protein in atria, in addition to histological analysis. Conduction velocity (CV) in right atrium was measured by optical mapping in Langendorff perfused hearts. Cultured atrial cardiomyocytes were treated with @entity8 with or without a specific microRNA inhibitor. Twelve hours after stimulation, cells were lysed, and subjected to analysis with qPCR and Western blotting. RESULTS: HFD @entity0 showed prolonged P wave duration, increased inducibility of sustained @entity4 , and reduced atrial CV than NC @entity0 . HFD @entity0 also showed increased expression in inflammatory cytokines, whereas fibrotic area and signals relating @entity3 were not changed. HFD @entity0 demonstrated reduced expression of @entity9 in mRNA and protein levels, and its lateralized expression in atria. MicroRNA array analysis revealed that @entity10 expression was up-regulated in HFD @entity0 , and luciferase assay confirmed the direct interaction between @entity10 and @entity9 3'UTR. In @entity8 -stimulated atrial cardiomyocytes, @entity10 up-regulation and @entity9 down-regulation were observed, while expression of inflammatory cytokines was not altered. Inhibition of @entity10 with antisense oligonucleotides reversed the alteration caused by @entity8 stimulation. CONCLUSION: HFD may increase the vulnerability to @entity5 by down-regulation of @entity9 via @entity10 , rather than @entity3 , which is independent of @entity2 .

title: High-fat diet increases vulnerability to XXXX by conduction disturbance via @entity10 .

answer: @entity5


abstract: BACKGROUND: Lifestyle-related diseases, such as @entity1 and @entity7 are important risk factors for @entity6 ( @entity6 ). However, the underlying mechanism linking these diseases and @entity6 has not been fully investigated. METHODS: Adult male @entity0 were fed a high-fat diet (HFD) or vehicle (NC) for 2months. Electrocardiography and in vivo electrophysiological study were performed. @entity0 were then sacrificed for quantification of mRNA, microRNA, and protein in atria, in addition to histological analysis. Conduction velocity (CV) in right atrium was measured by optical mapping in Langendorff perfused hearts. Cultured atrial cardiomyocytes were treated with @entity8 with or without a specific microRNA inhibitor. Twelve hours after stimulation, cells were lysed, and subjected to analysis with qPCR and Western blotting. RESULTS: HFD @entity0 showed prolonged P wave duration, increased inducibility of sustained @entity4 , and reduced atrial CV than NC @entity0 . HFD @entity0 also showed increased expression in inflammatory cytokines, whereas fibrotic area and signals relating @entity3 were not changed. HFD @entity0 demonstrated reduced expression of @entity9 in mRNA and protein levels, and its lateralized expression in atria. MicroRNA array analysis revealed that @entity10 expression was up-regulated in HFD @entity0 , and luciferase assay confirmed the direct interaction between @entity10 and @entity9 3'UTR. In @entity8 -stimulated atrial cardiomyocytes, @entity10 up-regulation and @entity9 down-regulation were observed, while expression of inflammatory cytokines was not altered. Inhibition of @entity10 with antisense oligonucleotides reversed the alteration caused by @entity8 stimulation. CONCLUSION: HFD may increase the vulnerability to @entity5 by down-regulation of @entity9 via @entity10 , rather than @entity3 , which is independent of @entity2 .

title: High-fat diet increases vulnerability to @entity5 by conduction disturbance via XXXX .

answer: @entity10


abstract: BACKGROUND: @entity1 ( @entity1 ) during high-resolution manometry (HRM) is increasingly utilized as provocative test to assess esophageal peristaltic reserve. The aim of this study was to evaluate the correlation between @entity1 response and impedance and pH (MII-pH) parameters in endoscopy negative heartburn (ENH) @entity0 . METHODS: We enrolled consecutive ENH @entity0 , who underwent HRM and MII-pH study, with a selected MII-pH profile: abnormal MII-pH (pH+/MII+); normal MII-pH (pH-/MII-). HRM was performed with 10 @entity1 ( @entity1 ) and one @entity1 . Mean distal contractile integral (DCI) during @entity1 and @entity1 were calculated. MII-pH parameters including acid exposure time (AET), reflux events, baseline impedance levels (BI) and the efficacy of chemical clearance evaluated with the postreflux swallow-induced peristaltic wave (PSPW) index were measured. KEY RESULTS: We analyzed 103 @entity0 : 49 MII+/pH+ (27 male), and 54 MII-/pH- (19 male). Mean age was similar between the two groups. As expected, mean AET and number of refluxes were higher in pH+/MII+ (p < 0.05). HRM was normal in all selected @entity0 . Mean DCI- @entity1 was similar between two groups (p = n.s.). Mean DCI- @entity1 - was higher in MII-/pH- vs MII+/pH+ (p < 0.05). The increase in DCI- @entity1 was inversely correlated with AET (-0.699; p < 0.001) and directly correlated with BI values (0.631; p < 0.001) and PSPW index (0.626; p < 0.001). CONCLUSIONS _ INFERENCES: Following @entity1 , @entity0 with abnormal impedance-pH test showed suboptimal contraction response as compared with those with normal impedance-pH test. Moreover, @entity1 response was inversely correlated with AET and directly correlated with BI values and PSPW index.

title: Vigor of peristalsis during multiple rapid swallows is inversely correlated with acid exposure time in XXXX with NERD.

answer: @entity0


abstract: UNASSIGNED: Despite the prevalence and  significant morbidity resulting from @entity3 receptor positive (ER(+)) @entity0 , there are only a few models of this @entity2 subtype available for drug development and arguably none for studying etiology. Those models that do exist have questionable clinical relevance. Given our goal of developing luminal models, we focused on six cell lines derived by minimal mutagenesis from normal @entity1 breast cells, and asked if any could generate clinically relevant xenografts, which we then extensively characterized. Xenografts of one cell line, 184AA3, consistently formed ER(+) @entity4 that had a high proliferative rate and other features consistent with "luminal B" intrinsic subtype. Squamous and spindle cell/mesenchymal differentiation was absent, in stark contrast to other cell lines that we examined or others have reported. We explored intratumoral heterogeneity produced by 184AA3 by immunophenotyping xenograft @entity2 and cultured cells, and characterized marker expression by immunofluorescence and flow cytometry. A @entity5 (High)  subpopulation was discovered, yet their @entity2 forming ability was far less than @entity5 (Low)  cells. Single cell cloning revealed the phenotypic plasticity of 184AA3, consistent with the intratumoral heterogeneity observed in xenografts. Characterization of ER expression in cultures revealed ER protein and signaling is intact, yet when @entity3 was depleted in culture, and  in vivo, it did not impact cell or @entity2 growth, analogous to therapeutically resistant ER(+)  @entity2 . This model is appropriate for studies of the etiology of ovarian hormone independent @entity4 , for identification of therapeutic targets, predictive testing, and drug development.

title: 184AA3: a xenograft model of ER(+) XXXX .

answer: @entity0


abstract: The study aimed to explore the changes of the immunocyte quantities and @entity0 in bone marrow, and how many @entity4 progenitor cells retained after the bone marrow cells were activated by different combinations of various cytokines. Bone marrow cells were divided into four groups and were cultured in vitro: (1) Control: no cytokines were added. (2) @entity3 group: bone marrow cells were activated by @entity3 . (3) CD3-AK group: bone marrow cells were activated by @entity3 and CD3-McAb. (4) CIK group: @entity1 , @entity2 , @entity3 and CD3-McAb were added. CFU-GM assay and CD3 phenotype detection were performed before and after activating culture in all groups. The changes of cell quantities during culture and @entity0 of cultured cells were tested. CD3 positive cells markedly increased in both CD3-AK and CIK groups. The cell numbers and @entity0 of CD3-AK and CIK groups were higher than those of control or @entity3 group obviously after culture (P < 0.05). CFU-GM were decreased in all groups after culture and there had no significant difference among four groups. The combination of @entity3 and CD3-McAb not only stimulates the proliferation of marrow immunocytes and increases their @entity0 but retains enough @entity4 progenitor cells as well. This combination of cytokines can be used to purge autologous bone marrow in vitro.

title: [Activation and XXXX of Bone Marrow Immunocytes by Using Various Cytokines]

answer: @entity0


abstract: OBJECTIVE: To highlight the various causes of gaze-evoked @entity3 . DESIGN: Retrospective noncomparative interventional case series. @entity0 : Five @entity0 treated at our facility over the past 6 years. METHODS: Clinical presentation, radiologic studies, surgical management, and postsurgical results are presented. MAIN OUTCOME MEASURES: Visual acuity, clinical findings of gaze-evoked @entity3 . RESULTS: Only two @entity0 had classic intraorbital etiologies, one with an intraconal @entity4 and one with an intraconal foreign body. Three @entity0 had extraorbital processes, two with @entity5 and one with a @entity1 . Only two of our @entity0 initially were aware of the gaze-evoked @entity3 at presentation. Appropriate surgery was curative in all cases. CONCLUSIONS: Gaze-evoked @entity3 is a rare condition, classically implicating intraconal orbital pathology. In one of the largest case series published to date, we found extraorbital etiologies are also capable of producing gaze-evoked @entity2 . Gaze-evoked @entity3 should be suspected and tested for in any orbital condition.

title: Gaze-evoked XXXX : a report of five cases.

answer: @entity3


abstract: A prospective study was carried out in the department of otolaryngology-Head _ Neck Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Bangladesh Medical college Hospital, Dhaka. From January, 2007 to January, 2009 to compare between @entity1 and Cold Dissection Tonsillectomy. Two hundred @entity0 were divided equally into two groups- @entity1 and cold dissection tonsillectomy. The two groups were compared in age and sex distribution but there was no significant difference (p>0.05) between the two groups. Operative time, operative @entity2 , @entity3 , diet intake, activity level and complications were compared in the two groups. Operative time and @entity2 was significantly less in the diathermy group which was highly significant (p<0.001). No significant difference (p>0.05) in the @entity3 was observed. Percentage of normal diet taken was higher in the diathermy group on the 1st day and lower on the 7th day while the difference was not statistically significant (p>0.05). No significant difference (p>0.05) was noted between the two groups in terms of postoperative activity and postoperative @entity2 . Operative @entity2 _ time was significantly less in @entity1 . So it is a safe technique and can be used safely with less morbidity _ complication.

title: Comparison between XXXX and cold dissection tonsillectomy.

answer: @entity1


abstract: OBJECTIVE: To investigate pathways involving beta-3 adrenergic receptors (ARs) in detrusor overactivity induced by cold stress, we determined if the beta-3 AR agonist @entity1 could modulate the cold stress-induced detrusor overactivity in normal @entity0 . METHODS: Two   days prior to cystometric investigations, the bladders of 10-week-old female @entity0 were cannulated. Cystometric measurements of the unanesthetized, unrestricted @entity0 were taken to estimate baseline values at room temperature (RT, 27        2     C) for 20   min. They were then intravenously administered vehicle, 0.1, or 1.0   mg/kg @entity1 (n   =   6 in each group). Five   minutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 4        2     C) room for 40   min where the cystometric measurements were again made. Afterward, the @entity0 were returned to RT for final cystometric measurements. The cystometric effects of @entity1 were also measured at RT (n   =   6 in each group). RESULTS: At RT, both low and high dose of @entity1 decreased basal and micturition pressure while the high dose (1.0   mg/kg) significantly increased voiding interval and bladder capacity. During LT exposure, the high dose of @entity1 partially reduced cold stress-induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle- and low dose (0.1   mg/kg)-treated @entity0 . CONCLUSION: A high dose of the beta-3 agonist @entity1 could modulate cold stress-induced detrusor overactivity. Therefore, one of the mechanisms in cold stress-induced detrusor overactivity includes a pathway involving beta-3 ARs.

title: Pathways Involving Beta-3 Adrenergic Receptors Modulate Cold Stress-Induced Detrusor Overactivity in Conscious XXXX .

answer: @entity0


abstract: Multiple studies have evaluated the use of @entity4 inhibitors in penile rehabilitation following nerve-sparing prostatectomy. These studies have evaluated the use of various pharmacologic agents as well as various approaches to treatment (on-demand vs. rehabilitative). Most of these studies relied on self-reported outcomes to determine efficacy of the therapy which could allow response bias to affect their results. The aim of this study was to evaluate the effects of nightly @entity3 therapy during penile rehabilitation, using @entity2 (RigiScan(   ) , Gotop Medical, Inc., St. Paul, MN, USA) in addition to the IIEF-EF. @entity0 with @entity1 and normal erectile function prior to nsRP were randomized to take either nightly 50  mg @entity3 or placebo starting the night following surgery. Both groups were allowed on-demand @entity3 . Erectile function was evaluated at 2  weeks, 3, 6, 9 and 12  months post-operatively, with a final assessment made at 13  months, following a 1  month drug washout. At all time points, self-reported (IIEF-EF) and objective (RigiScan(   ) ) measures were obtained and evaluated. About 74 of 97 randomized @entity0 completed the study. On completion, 40% of @entity0 in each group had normal erectile function based on RigiScan(   ) (p  =  1.0). Additionally, no statistical differences were seen using the IIEF-EF domain (32.4% of placebo, 29% of treatment; p  =  0.79). Multivariable analysis showed no significant differences in erectile function based on treatment intervention. Results did show that African-American @entity0 in this cohort were at higher risk for lower RigiScan(   ) scores over time (OR: 0.48, p  =  0.0399). This study demonstrates that nightly @entity3 does not provide a therapeutic benefit for recovery of erectile function post-prostatectomy when compared to on-demand dosing using both self-reported as well as objective measures. Differences in objective recovery parameters based on @entity0 ' race/ethnicity warrant further investigation.

title: A prospective, randomized, placebo-controlled trial of on-Demand vs. nightly XXXX as assessed by Rigiscan and the international index of erectile function.

answer: @entity3


abstract: OBJECTIVES: To explore @entity0 's accounts of their experiences of the UK's largest @entity1 programme, @entity3 (Mind, Exercise, Nutrition   Do it!) (See www.mendprogramme.org). DESIGN: Semi-structured interviews were conducted with @entity0 who had completed the @entity3 @entity1 programme. Interviews were transcribed verbatim and analysed using Interpretative Phenomenological Analysis (IPA). METHOD: Fourteen @entity0 spanning diverse areas of London comprised this study (eight male, six female), aged between 11 and 14  years and in secondary school. @entity0 were interviewed a year after completing one of the London-based @entity3 @entity1 programmes. RESULTS: This article focuses on the most common and striking theme to emerge from the original dataset (The complete analysis may be found in L. Watson, Unpublished doctoral thesis): Fun. Subthemes were: 'going with the flow'; active participation in activities that led to new experiences ('actually doing it' - seeing the fun side); the importance of others in the experience of fun ('you do games in unity' - 'it's not as fun on your own'). CONCLUSION: @entity0 have fun when engaged in interactive and varied activities with opportunity for individual feedback and improvement. When designing @entity1 programmes, conditions that optimise @entity0 's experience of fun should be emphasised over didactic and risk-heavy information pertaining to @entity1 . Statement of contribution What is already known on this subject? Continued growth in @entity1 and its associated health problems, psychological effects, and economic @entity2 tackling @entity1 a public health priority. Multicomponent lifestyle interventions to treat @entity1 within the community have been shown to reduce overweight and @entity1 from pre- to post-treatment, increase self-esteem, and are found to be acceptable by parents. @entity3 is the most widely disseminated evidence-based programme of this kind in the United Kingdom. What does this study add? This study is the first qualitative study to explore the @entity0 's experience of attending @entity3 . The post-treatment maintenance period, where most behaviour change is consolidated (or not), is also captured in this study, with @entity0 interviewed at least 1  year post-treatment. Findings unearthed an unexpected and strong theme - that of 'fun' - integral to their experience during their time at @entity3 . Optimizing conditions for fun is imperative to @entity0 's (and adults'?) engagement with, and maintenance of, healthy lifestyle activities.

title: Kids just wanna have fun: XXXX 's experiences of a weight management programme.

answer: @entity0


abstract: AIM: To examine the relationships between maternal @entity3 c concentration at different time points and birth weight in pregnancies complicated by pre-existing @entity2 1 @entity1 . METHODS: A comprehensive audit dataset was collected prospectively on all deliveries in Scotland to @entity0 with pre-existing @entity2 1 @entity1 occurring between 1 April 1998 and 31 March 1999. Data items included @entity3 c concentrations prior to conception and in each of the three trimesters of pregnancy, and birth weight. Relationships between standardized birth weight and HbA1c concentrations at each of the four time points were examined using correlation analysis. RESULTS: Standardized birth weight (Z scores) could be calculated for 203 of 208 singleton liveborn @entity0 . HbA1c concentrations, standardized to correct for assay differences among hospitals, at different time points were available for between 134 (pre-pregnancy) and 192 (third trimester) cases. Standardized birth weight, relative to a reference population, showed a unimodal distribution, shifted to the right (mean, +1.57 sd). There was a significant negative correlation between pre-pregnancy @entity3 c and birth weight (Spearman's R, -0.208; P = 0.016). There were no statistically significant correlations for other time points. CONCLUSIONS: Standardized birth weight scores of the @entity0 of @entity1 mothers are higher than those of a reference population. There is no simple relationship between maternal glycaemic status and birth weight, but there appears to be a paradoxical inverse relationship between pre-pregnancy glycaemic control and standardized birth weight.

title: The relationship between birth weight and maternal glycated haemoglobin (HbA1c) concentration in pregnancies complicated by XXXX 1 @entity1 .

answer: @entity2


abstract: AIM: To examine the relationships between maternal @entity3 c concentration at different time points and birth weight in pregnancies complicated by pre-existing @entity2 1 @entity1 . METHODS: A comprehensive audit dataset was collected prospectively on all deliveries in Scotland to @entity0 with pre-existing @entity2 1 @entity1 occurring between 1 April 1998 and 31 March 1999. Data items included @entity3 c concentrations prior to conception and in each of the three trimesters of pregnancy, and birth weight. Relationships between standardized birth weight and HbA1c concentrations at each of the four time points were examined using correlation analysis. RESULTS: Standardized birth weight (Z scores) could be calculated for 203 of 208 singleton liveborn @entity0 . HbA1c concentrations, standardized to correct for assay differences among hospitals, at different time points were available for between 134 (pre-pregnancy) and 192 (third trimester) cases. Standardized birth weight, relative to a reference population, showed a unimodal distribution, shifted to the right (mean, +1.57 sd). There was a significant negative correlation between pre-pregnancy @entity3 c and birth weight (Spearman's R, -0.208; P = 0.016). There were no statistically significant correlations for other time points. CONCLUSIONS: Standardized birth weight scores of the @entity0 of @entity1 mothers are higher than those of a reference population. There is no simple relationship between maternal glycaemic status and birth weight, but there appears to be a paradoxical inverse relationship between pre-pregnancy glycaemic control and standardized birth weight.

title: The relationship between birth weight and maternal glycated haemoglobin (HbA1c) concentration in pregnancies complicated by @entity2 1 XXXX .

answer: @entity1


abstract: AIM: The study investigated clinical and social changes during an 18-month follow-up period in a group (n = 76) of @entity2 outpatients admitted to a newly implemented outpatient @entity3 team. Changes related to level of contact with the @entity3 team were also examined as well as aspects of the content of the treatment interventions and work situation from a staff perspective. METHODS: Structured face-to-face interviews with the @entity0 were performed at baseline and after 18 months. The Camberwell Assessment of Need instrument, the Lancashire Quality of Life Profile and the Interview Schedule for Social Interaction were used on both interview occasions along with Global Assessment of Functioning Scale and Brief Psychiatric Rating Scale. Thematic open-ended questions were used in staff interviews. RESULTS: Psychiatric symptoms, number of needs and number of met needs decreased, and perceived quality of life improved for the total sample during the follow-up period. @entity0 only in contact with a psychiatrist in the @entity3 team improved more in symptoms and spent fewer days in hospital during follow-up time compared with those who had combined @entity1 and supportive contacts, and were also more satisfied with their medication. @entity0 with a combined contact deteriorated in psychosocial functioning compared with the group only in contact with a psychiatrist. Some of the elements in treatment interventions and work situation as well as hindrances in providing community-based care adapted to the @entity0 ' needs were identified. CONCLUSIONS: Community-based @entity1 services, to a larger extent, need to embrace evidence-based interventions and to perform regular, structured and comprehensive need assessments in order to ensure the effectiveness of interventions. Attention should be paid to staff motivation and education as well as to providing practical guidelines, supervision and support.

title: Clinical and social changes in severely mentally ill individuals admitted to an outpatient XXXX team: an 18-month follow-up study.

answer: @entity3


abstract: BACKGROUND: In this study we evaluate the association between @entity2 to high-density lipoprotein @entity1 (TG/ @entity5 ) ratio and total @entity1 (TC) to @entity5 ( @entity5 ) ratio and the risks of @entity4 ( @entity4 ) in an Iranian high-risk population. METHODS: We analysed 7-year follow-up data (n   =   1,771) in non-diabetic first-degree relatives of consecutive @entity0 with @entity4 30-70 years old. The primary outcome was the diagnosis of @entity4 based on repeated oral @entity3 tolerance tests. We used Cox proportional hazard models to estimate hazard ratio (HR) for incident @entity4 across tertiles of TG/ @entity5 and @entity5 ratios and plotted a receiver operating characteristic (ROC) curve to assess discrimination. RESULTS: The highest tertile of TG/ @entity5 and @entity5 ratios compared with the lowest tertile was not associated with @entity4 in age and gender adjusted models (HR 0.99, 95% CI: 0.88, 1.11 for TG/ @entity5 ratio and 1.10, 95% CI: 0.97, 1.23 for @entity5 ratio). Further adjustment for waist circumference or body mass index, fasting plasma @entity3 , and low-density lipoprotein @entity1 did not appreciably alter the HR compared to the age- and gender-adjusted model. The area under the ROC curve for TG/ @entity5 ratio was 57.7% (95% CI: 54.0, 61.5) and for @entity5 ratio was 55.1% (95% CI: 51.2, 59.0). CONCLUSIONS: TG/ @entity5 and @entity5 ratios were not robust predictors of @entity4 in high-risk individuals in Iran. This article is protected by copyright. All rights reserved.

title: Utility of serum lipid ratios for predicting XXXX : the Isfahan Diabetes Prevention Study.

answer: @entity4


abstract: A 74-year-old @entity0 with @entity4 underwent upper @entity9 was found in the middle thoracic esophagus. Histological examination with endoscopic biopsies revealed @entity6 ( @entity6 ), and chromoendoscopy with @entity8 staining revealed that the superficial @entity6 involved nearly the entire circumference of the esophageal lumen. There were neither nodal nor distant metastases. @entity10 (ESD) was successfully achieved with @entity1 -free margins in an en bloc fashion. The histopathological examination confirmed a diagnosis of @entity2 limited to the lamina propria mucosae without angiolymphatic invasion. Oral @entity5 was started with 0.5 mg/kg daily on the 3rd post-ESD day, tapered gradually, and then discontinued 8 weeks later without adverse effects. There were no complaints of @entity7 following ESD. On follow-up endoscopy with @entity8 staining, which was scheduled at 1, 3 and 6 months after ESD, there was no postprocedural esophageal stricture, and neither recurrent nor metachronous lesions were found. Thus, the @entity0 required no sessions of @entity3 . At the last outpatient clinic visit 7 months after ESD, he remained well without @entity7 . Oral @entity5 administration may offer an effective therapeutic strategy to prevent the post-ESD esophageal stricture after complete circular ESD.

title: Effect of oral XXXX on esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: a case report.

answer: @entity5


abstract: @entity3 ( @entity4 ) is an abundant natural @entity5 with antioxidant properties. Under different conditions, it can play protective as well as pathogenic roles. The redox state of the cell has an important role in the induction of apoptosis. Elevated level of @entity3 in @entity1 cells provides resistance to a number of chemotherapeutic drugs. Inhibition of @entity3 synthesis sensitizes the cells for apoptosis and enhances the activity of chemotherapeutic drugs. We have selected @entity4 -binding RNA aptamers by employing in vitro selection protocol SELEX. The Kd value of these aptamers with respect to @entity4 were determined by surface plasmon resonance (SPR) analysis and isocratic affinity chromatography. Two aptamers GSHapt 8.17 (class-III) and @entity4 apt 5.39 (class-IV) had Kd values of 4.18 and 4.89 x 10(-8) M, respectively and GSHapt class-I had a Kd value of 1.2 x 10(-6) M. CD spectra suggested conformational change in aptamers upon @entity4 binding. Cultured @entity0 cells (MCF7) responded to expression of @entity4 aptamers by accumulating ROS and undergoing morphological transition, nuclear condensation, and DNA fragmentation, with concurrent depletion of cellular @entity4 and activation of @entity2 eventually leading to apoptosis. DTT and @entity2 inhibitor partially rescued aptamer induced apoptosis. These aptamers exhibit high specificity to @entity4 over non specific competitor. The same aptamers did not induce apoptosis in 293T cells. The kinetic properties and pro-apoptotic effects suggest that @entity3 -binding RNA aptamer could be developed into an effective anti- @entity1 chemotherapeutic agent.

title: In vitro selected RNA aptamer recognizing @entity3 induces ROS mediated apoptosis in the human XXXX cell line MCF 7.

answer: @entity0


abstract: @entity3 ( @entity4 ) is an abundant natural @entity5 with antioxidant properties. Under different conditions, it can play protective as well as pathogenic roles. The redox state of the cell has an important role in the induction of apoptosis. Elevated level of @entity3 in @entity1 cells provides resistance to a number of chemotherapeutic drugs. Inhibition of @entity3 synthesis sensitizes the cells for apoptosis and enhances the activity of chemotherapeutic drugs. We have selected @entity4 -binding RNA aptamers by employing in vitro selection protocol SELEX. The Kd value of these aptamers with respect to @entity4 were determined by surface plasmon resonance (SPR) analysis and isocratic affinity chromatography. Two aptamers GSHapt 8.17 (class-III) and @entity4 apt 5.39 (class-IV) had Kd values of 4.18 and 4.89 x 10(-8) M, respectively and GSHapt class-I had a Kd value of 1.2 x 10(-6) M. CD spectra suggested conformational change in aptamers upon @entity4 binding. Cultured @entity0 cells (MCF7) responded to expression of @entity4 aptamers by accumulating ROS and undergoing morphological transition, nuclear condensation, and DNA fragmentation, with concurrent depletion of cellular @entity4 and activation of @entity2 eventually leading to apoptosis. DTT and @entity2 inhibitor partially rescued aptamer induced apoptosis. These aptamers exhibit high specificity to @entity4 over non specific competitor. The same aptamers did not induce apoptosis in 293T cells. The kinetic properties and pro-apoptotic effects suggest that @entity3 -binding RNA aptamer could be developed into an effective anti- @entity1 chemotherapeutic agent.

title: In vitro selected RNA aptamer recognizing XXXX induces ROS mediated apoptosis in the human @entity0 cell line MCF 7.

answer: @entity3


abstract: During the past 5 years, progress in the treatment of pressure ulcers appears to have reached a plateau. Several factors in the design of recent clinical studies may have contributed to this situation. These factors include the criteria chosen for @entity0 selection, small sample size, and lack of a concisely defined final clinical outcome. Hunt noted that wound stratification according to a @entity0 's physiological characteristics may be a key to quantifying differences among clinical treatments. To address this issue, we examined the expression of cyclin D/ @entity2 in pressure @entity1 fibroblasts taken from tissues during a recent clinical trial. The treatment groups included @entity0 treated with the following regimens: placebo, granulocyte macrophage-colony stimulating factor alone, basic fibroblast growth factor alone, or granulocyte macrophage-colony stimulating factor and basic fibroblast growth factor given in sequence. Immunocytochemical colocalization of cyclin D and @entity2 showed that, before the initial treatment began, @entity0 were distributed disproportionately among treatment subgroups in regards to the initial expression of these markers. For example, we found that compared with other subgroups, @entity1 fibroblasts in the basic fibroblast growth factor treatment group showed a much lower expression of cyclin D/ @entity2 at day 0. However, this group exhibited higher levels of expression of this complex after 35 days of treatment. This study shows that measurement of cyclin D/ @entity2 expression permits more accurate stratification of @entity0 within treatment subgroups, measurement of a cell's ability to detect the presence of functional cytokines, identification of area(s) of failure within the G1 of the cell cycle, and a basis for critical evaluation of various treatments.

title: Significance of cell cycle for wound stratification in clinical trials: analysis of a pressure XXXX clinical trial utilizing cyclin D/ @entity2 .

answer: @entity1


abstract: During the past 5 years, progress in the treatment of pressure ulcers appears to have reached a plateau. Several factors in the design of recent clinical studies may have contributed to this situation. These factors include the criteria chosen for @entity0 selection, small sample size, and lack of a concisely defined final clinical outcome. Hunt noted that wound stratification according to a @entity0 's physiological characteristics may be a key to quantifying differences among clinical treatments. To address this issue, we examined the expression of cyclin D/ @entity2 in pressure @entity1 fibroblasts taken from tissues during a recent clinical trial. The treatment groups included @entity0 treated with the following regimens: placebo, granulocyte macrophage-colony stimulating factor alone, basic fibroblast growth factor alone, or granulocyte macrophage-colony stimulating factor and basic fibroblast growth factor given in sequence. Immunocytochemical colocalization of cyclin D and @entity2 showed that, before the initial treatment began, @entity0 were distributed disproportionately among treatment subgroups in regards to the initial expression of these markers. For example, we found that compared with other subgroups, @entity1 fibroblasts in the basic fibroblast growth factor treatment group showed a much lower expression of cyclin D/ @entity2 at day 0. However, this group exhibited higher levels of expression of this complex after 35 days of treatment. This study shows that measurement of cyclin D/ @entity2 expression permits more accurate stratification of @entity0 within treatment subgroups, measurement of a cell's ability to detect the presence of functional cytokines, identification of area(s) of failure within the G1 of the cell cycle, and a basis for critical evaluation of various treatments.

title: Significance of cell cycle for wound stratification in clinical trials: analysis of a pressure @entity1 clinical trial utilizing cyclin D/ XXXX .

answer: @entity2


abstract: @entity2 canis and @entity2 gibsoni have, until recently, been considered the only piroplasms that parasitise @entity0 . However, recent reports indicate that "small" @entity1 in Spanish @entity0 are surprisingly frequent and molecular phylogenetic analysis indicates that the infecting agent is closely related to @entity2 microti. Because the 18SrDNA sequence was not completely identical to that of @entity5 , the new name "Theileria annae" was assigned to the @entity0 agent. No information is available regarding the possible vector of the new piroplasm, T. annae. As part of an effort to identify the tick that may transmit T. annae in northwest Spain we asked veterinary surgeons practising in the region to collect and send to our laboratory ticks from @entity0 visiting their clinics. Seven hundred and twenty ticks collected from @entity0 of unknown clinical status during 1998 and 636 ticks collected between November 2001 and March 2002 from 38 @entity0 infected with T. annae and 131 uninfected @entity0 were identified. Results from the first study indicated that among the Ixodidae, @entity4 clearly predominates over Ixodes ricinus (26.11% versus 6.67%). This observation was consistent with results of the second study, in which @entity4 was detected in all infected @entity0 and 71.8% of non-infected @entity0 and I. ricinus was not detected in either the infected or non-infected @entity0 . Results from the 2001-2002 study also indicate that the presence of Dermacentor reticulatus adult females is significantly less frequent among infected than non-infected @entity0 (OR=0.44; 95% CI: 0.21-0.92). On the other hand, @entity4 adult females and males are 6.75 and 4.24 times more likely to be detected among infected than non-infected @entity0 , respectively, with the association being, in both cases, statistically significant (95% CI: 1.97-23.12 and 1.92-9.36, respectively). @entity4 emerges as the main candidate as vector of T. annae because it feeds on @entity0 more frequently than other ticks and because @entity5 is transmitted by Ixodes ticks, both in North America and Europe. In the absence of definitive confirmation of this hypothesis, our observations suggest that @entity4 might serve the same role as does @entity3 (= @entity3 ), the vector of @entity5 in eastern North America.

title: XXXX is the main candidate as vector of Theileria annae in northwest Spain.

answer: @entity4


abstract: @entity6 is an established cause of @entity4 . Particulate air pollution is known to exacerbate @entity2 , particularly in susceptible populations. This study set out to determine the impact of exposure to traffic pollution, with and without particle filtration, on vascular endothelial function in @entity6 . Endothelial production of @entity5 (NO) has previously been linked to vascular health. @entity3 induces a significant increase in plasma @entity7 , the proximal metabolite of NO, in healthy subjects, while @entity0 have a lower and more variable level of response. Twenty type II @entity0 and 20 controls (ages 46-70 years) were taken on a 1.5 hr roadway traffic air pollution exposure as passengers. We analyzed plasma @entity7 , as a measure of vascular function, using forearm @entity1 to elicit a reactive hyperemic response before and after exposure to one ride with and one without filtration of the particle components of pollution. Control subjects displayed a significant increase in plasma @entity7 levels during reactive @entity3 . This response was no longer present following exposure to traffic air pollution, but did not vary with whether or not the particle phase was filtered out. Diabetics did not display an increase in @entity7 levels following reactive @entity3 . This response was not altered following pollution exposure. These data suggest that components of acute traffic pollution exposure diminish vascular reactivity in non- @entity0 individuals. It also confirms that type II @entity0 have a preexisting diminished ability to appropriately respond to a vascular challenge, and that traffic pollution exposure does not cause a further measureable acute change in plasma @entity7 levels in @entity6 .

title: Disrupted @entity5 Metabolism from XXXX and Acute Exposure to Particulate Air Pollution.

answer: @entity6


abstract: @entity6 is an established cause of @entity4 . Particulate air pollution is known to exacerbate @entity2 , particularly in susceptible populations. This study set out to determine the impact of exposure to traffic pollution, with and without particle filtration, on vascular endothelial function in @entity6 . Endothelial production of @entity5 (NO) has previously been linked to vascular health. @entity3 induces a significant increase in plasma @entity7 , the proximal metabolite of NO, in healthy subjects, while @entity0 have a lower and more variable level of response. Twenty type II @entity0 and 20 controls (ages 46-70 years) were taken on a 1.5 hr roadway traffic air pollution exposure as passengers. We analyzed plasma @entity7 , as a measure of vascular function, using forearm @entity1 to elicit a reactive hyperemic response before and after exposure to one ride with and one without filtration of the particle components of pollution. Control subjects displayed a significant increase in plasma @entity7 levels during reactive @entity3 . This response was no longer present following exposure to traffic air pollution, but did not vary with whether or not the particle phase was filtered out. Diabetics did not display an increase in @entity7 levels following reactive @entity3 . This response was not altered following pollution exposure. These data suggest that components of acute traffic pollution exposure diminish vascular reactivity in non- @entity0 individuals. It also confirms that type II @entity0 have a preexisting diminished ability to appropriately respond to a vascular challenge, and that traffic pollution exposure does not cause a further measureable acute change in plasma @entity7 levels in @entity6 .

title: Disrupted XXXX Metabolism from @entity6 and Acute Exposure to Particulate Air Pollution.

answer: @entity5


abstract: UNASSIGNED: A longer duration of untreated @entity4 (DUP) has been associated with poor clinical outcomes in @entity0 with @entity2 ( @entity2 ); however, it remains unclear whether this is due to @entity5 effects of @entity4 . The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in @entity0 with first-episode @entity2 (FES). A total of 28 FES @entity0 and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES @entity0 . However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because @entity3 result in @entity1 long before psychotic symptoms onset.

title: Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode XXXX : A Near-Infrared Spectroscopy Study.

answer: @entity2


abstract: @entity6 play a major role in the prevention of @entity0 @entity4 by protecting the pregnant @entity0 from teratogenic or otherwise harmful infections. Until now, it has not been common practice to perform preclinical developmental @entity2 tests for new vaccines. Despite the excellent safety record of vaccines, increased attention is now being given to the feasibility of screening new vaccines for developmental hazards in animals before their use in @entity0 . Contrary to previous assumptions, many vaccines are now given to potentially pregnant @entity0 . Any new components of the vaccine formulation (adjuvants, excipients, stabilisers, preservatives, etc.) could also be tested for influences on development, although based on past experience the risks are limited by the very low dosages used. The conferred immunity following vaccination lasts for several years. Therefore, the developing conceptus may theoretically be exposed to the induced antibodies and/or sensitised T-cells, even if the pregnant @entity0 was last vaccinated during childhood (particularly if she encounters the antigen during pregnancy through exposure to @entity3 ). However, it should be kept in mind that viral or @entity5 represent a higher risk for a pregnant @entity0 than the potential adverse effects related to vaccination or the associated immune response. Non-clinical safety studies may be employed as an aid for hazard identification. In these studies interactions of the vaccine with the maternal immune system or with the developmental systems of the offspring are considered. Post-natal examinations are necessary to detect all possible manifestations of developmental @entity2 , such as effects on the immune system. Species selection for the preclinical studies is based on immunogenicity to the vaccine and the relative timing and rate of transfer of maternal antibodies to the offspring. A single study design is proposed for the pre- and post-natal developmental assessments of vaccines in rodents and @entity1 .

title: Reproductive XXXX testing of vaccines.

answer: @entity2


abstract: The t(8;14)(q11.2;q32) is emerging as an uncommon, though recurrent cytogenetic finding. As of yet, too few cases of @entity1 ( @entity1 ) characterized by this translocation have been studied to determine its prognostic significance with confidence. We therefore report three new @entity0 (two male @entity0 and one adult female) and present their hematologic, immunophenotypic, and clinical data. The clinical and laboratory characteristics of 26 other @entity0 with t(8;14)(q11.2;q32) are summarized. The total number of @entity0 now reported in the literature is 29 with a mean age of 14 years. Early relapse, that is, relapse within 6 months, does not appear to be a common feature of this group. The gender distribution is 19 males: 9 females (gender not reported in one case). Twenty-three t(8;14) @entity0 show a pre-B immunophenotype and 24 of 24, on whom information is available, achieved complete remission after induction chemotherapy for B- @entity1 . Approximately one third of @entity0 with t(8;14) have Down syndrome, 19 of 27 have additional acquired cytogenetic abnormalities, 5 of these have the t(9;22), and 4 show duplication of the abnormal chromosome 14, which is derived from the t(8;14). Hemoglobin and platelet counts are low at presentation in 10 of 10 and 8 of 9 @entity0 , respectively, and the average white blood count is 38.9 x 10(9)/L. Of the 7 @entity0 for whom @entity2 status has been determined, all show rearrangement of the @entity2 locus. Two of the present three @entity0 are included in this group; their @entity2 rearrangement was demonstrated by fluorescence in situ hybridization with @entity2 break-apart probes.

title: XXXX characterized by t(8;14)(q11.2;q32).

answer: @entity1