abstract: The peptide @entity2 (SS) is widely distributed in the @entity0 brain where it modulates neuronal activity through interactions with specific membrane-bound receptor subtypes (ssts). Five different ssts were characterized so far (sst1-5) and their selective agonists were developed on the basis of their binding specificity. SS and ssts are transiently expressed in the developing brain, suggesting a functional role of somatostatinergic systems in neuronal maturation. In the present study, we investigated the effects of chronic exposure to either the SS synthetic analogue, @entity4 or @entity3 (a long-acting sst2-preferring analogue) on the maturation of SS-immunoreactivity (-ir) in the primary visual cortex of the @entity1 . SS-ir maturation was investigated both by an evaluation of the number of SS-immunoreactive cells and by radioimmunoassay (RIA) to measure the levels of SS in the postnatal visual cortex. In the visual cortex of normal @entity1 , the number of SS-positive cells markedly increased during the second postnatal week and then significantly decreased until the adult value was reached at the third week. Early and repeated intracerebroventricular (i.c.v.) injections of either @entity4 or @entity3 prevented the increase in the number of SS-positive cells, with adult values reached at the end of the first postnatal week. Similarly, administration of either @entity4 or @entity3 significantly decreased the SS content of the visual cortex, measured at the end of the second postnatal week. These results show that high local concentrations of either @entity4 or @entity3 interfere with SS expression in developing cortical neurons in a restricted postnatal period.

title: Chronic exposure to either XXXX (SS) or @entity3 , a long-lasting SS analogue, affects SS expression in the postnatal visual cortex of the @entity1 .

answer: @entity2


abstract: The peptide @entity2 (SS) is widely distributed in the @entity0 brain where it modulates neuronal activity through interactions with specific membrane-bound receptor subtypes (ssts). Five different ssts were characterized so far (sst1-5) and their selective agonists were developed on the basis of their binding specificity. SS and ssts are transiently expressed in the developing brain, suggesting a functional role of somatostatinergic systems in neuronal maturation. In the present study, we investigated the effects of chronic exposure to either the SS synthetic analogue, @entity4 or @entity3 (a long-acting sst2-preferring analogue) on the maturation of SS-immunoreactivity (-ir) in the primary visual cortex of the @entity1 . SS-ir maturation was investigated both by an evaluation of the number of SS-immunoreactive cells and by radioimmunoassay (RIA) to measure the levels of SS in the postnatal visual cortex. In the visual cortex of normal @entity1 , the number of SS-positive cells markedly increased during the second postnatal week and then significantly decreased until the adult value was reached at the third week. Early and repeated intracerebroventricular (i.c.v.) injections of either @entity4 or @entity3 prevented the increase in the number of SS-positive cells, with adult values reached at the end of the first postnatal week. Similarly, administration of either @entity4 or @entity3 significantly decreased the SS content of the visual cortex, measured at the end of the second postnatal week. These results show that high local concentrations of either @entity4 or @entity3 interfere with SS expression in developing cortical neurons in a restricted postnatal period.

title: Chronic exposure to either @entity2 (SS) or XXXX , a long-lasting SS analogue, affects SS expression in the postnatal visual cortex of the @entity1 .

answer: @entity3


abstract: The peptide @entity2 (SS) is widely distributed in the @entity0 brain where it modulates neuronal activity through interactions with specific membrane-bound receptor subtypes (ssts). Five different ssts were characterized so far (sst1-5) and their selective agonists were developed on the basis of their binding specificity. SS and ssts are transiently expressed in the developing brain, suggesting a functional role of somatostatinergic systems in neuronal maturation. In the present study, we investigated the effects of chronic exposure to either the SS synthetic analogue, @entity4 or @entity3 (a long-acting sst2-preferring analogue) on the maturation of SS-immunoreactivity (-ir) in the primary visual cortex of the @entity1 . SS-ir maturation was investigated both by an evaluation of the number of SS-immunoreactive cells and by radioimmunoassay (RIA) to measure the levels of SS in the postnatal visual cortex. In the visual cortex of normal @entity1 , the number of SS-positive cells markedly increased during the second postnatal week and then significantly decreased until the adult value was reached at the third week. Early and repeated intracerebroventricular (i.c.v.) injections of either @entity4 or @entity3 prevented the increase in the number of SS-positive cells, with adult values reached at the end of the first postnatal week. Similarly, administration of either @entity4 or @entity3 significantly decreased the SS content of the visual cortex, measured at the end of the second postnatal week. These results show that high local concentrations of either @entity4 or @entity3 interfere with SS expression in developing cortical neurons in a restricted postnatal period.

title: Chronic exposure to either @entity2 (SS) or @entity3 , a long-lasting SS analogue, affects SS expression in the postnatal visual cortex of the XXXX .

answer: @entity1


abstract: UNASSIGNED: @entity4 ( @entity4 ) is the most common @entity2 in childhood. Without an effective therapy, @entity0 may progress quickly to functional disability. Recently, depletion of B cells emerged as a new approach for the treatment of @entity3 , including @entity4 . We describe six cases of @entity4 @entity0 followed at a referral center for Rheumatology and Pediatric Rheumatology, submitted to treatment with rituximab (RTX) after refractoriness to three anti-TNF agents. @entity0 received RTX cycles with two infusions every six months. Response to treatment was assessed by DAS28, HAQ/CHAQ, and an overall assessment by the doctor and the @entity0 . Of our six @entity0 , four were @entity0 (mean age at onset of disease: 6.1 years; mean disease evolution time: 15.1 years; mean age upon receiving RTX: 21.6 years). Four @entity0 belonged to polyarticular subtype (1 rheumatoid factor [RF]-negative, 3 FR-positive), a @entity0 with systemic @entity4 subtype with a polyarticular course and @entity1 related to @entity4 . Of our six @entity0 , five responded to treatment; and during the course of 12 months, the clinical response was maintained, although not sustained. However, discontinuation by infusion reactions caused the withdrawal of RTX in two @entity0 . The use of RTX in @entity4 is restricted to cases refractory to other biological agents and, even considering that this study was held in a small number of advanced @entity0 , RTX proved to be an effective therapeutic option.

title: [Rituximab use in young adults diagnosed with XXXX unresponsive to conventional treatment: report of 6 cases].

answer: @entity4


abstract: PURPOSE: Excitotoxicity has been linked to the pathogenesis of @entity7 and @entity3 and may involve @entity4 of both anterior and posterior visual pathways. However, their spatiotemporal relationships remain unclear. We hypothesized that the effects of excitotoxic @entity6 (ERI) on the visual system can be revealed in vivo by diffusion tensor magnetic resonance imagining (DTI), @entity5 -enhanced magnetic resonance imagining (MRI), and optical coherence tomography (OCT). METHODS: Diffusion tensor MRI was performed at 9.4 Tesla to monitor white matter integrity changes after unilateral @entity8 ( @entity8 )-induced ERI in six @entity2 and six C57BL/6J @entity1 . Additionally, four @entity2 and four @entity1 were intravitreally injected with saline to compare with @entity8 -injected animals. Optical coherence tomography of the retina and @entity5 -enhanced MRI of anterograde transport were evaluated and correlated with DTI parameters. RESULTS: In the @entity2 optic nerve, the largest axial diffusivity decrease and radial diffusivity increase occurred within the first 3 and 7 days post ERI, respectively, suggestive of early @entity4 and delayed @entity0 . The optic tract showed smaller directional diffusivity changes and weaker DTI correlations with retinal thickness compared with optic nerve, indicative of anterograde degeneration. The splenium of corpus callosum was also reorganized at 4 weeks post ERI. The DTI profiles appeared comparable between @entity2 and @entity1 models. Furthermore, the @entity8 -injured visual pathway showed reduced anterograde @entity5 transport, which correlated with diffusivity changes along but not perpendicular to optic nerve. CONCLUSIONS: Diffusion tensor MRI, @entity5 -enhanced MRI, and OCT provided an in vivo model system for characterizing the spatiotemporal changes in white matter integrity, the eye-brain relationships and structural-physiological relationships in the visual system after ERI.

title: In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After XXXX With Multimodal MRI and OCT.

answer: @entity6


abstract: AIMS: Evaluation of the morphological damage to the ocular surface of @entity0 operated for biliopancreatic diversion for pathological @entity1 and the correlation of impression cytology with @entity3 plasma levels, adaptometry, and other general variables. METHODS: 48 @entity0 (15 males, 33 females, age range 21-73) and 34 normal subjects were examined with @entity4 and rose bengal, a plasma dose of @entity3 , and adaptometry. The results of the various tests were subdivided into three levels (0 = normal, 1 = moderately altered, 2 = seriously altered). The impression cytology and adaptometry results were correlated with @entity3 levels and other @entity0 data (age, nutritional condition, time since operation, percentage @entity2 ). All the examinations were repeated after intramuscular therapy with @entity3 . RESULTS: Corneoconjunctival alterations visible with @entity4 and rose bengal staining were present in 67.7% of cases, impression cytology alterations in 93.7%, adaptometric alterations in 82.2%; @entity3 plasma levels were below normal in 95.8% of cases. After the therapy with @entity3 a significant reduction was found for every examination. The correlation between impression cytology and adaptometry and @entity3 plasma levels and between corneoconjunctival alterations and @entity3 plasma levels was significant. There was no significant correlation between impression cytology and nutritional condition, age time since operation, and percentage @entity2 . CONCLUSION: These results show impression cytology is a specific indicator for @entity5 because it is not influenced by other factors related to the general condition of the @entity0 . Many @entity0 with @entity5 not demonstrating ocular symptoms of changes visible with @entity4 and rose bengal showed alterations with impression cytology.

title: Role of impression cytology during XXXX .

answer: @entity5


abstract: The primary goal of this retrospective study was to determine the most effective treatment protocol to @entity3 @entity0 with @entity2 ( @entity2 ) to their original jobs. By examining a homogeneous subject pool and using specific, functional outcome measures determined by what is needed to reduce @entity3 costs, a treatment protocol could be developed benefiting both the employer and employee. A total of 121 charts of @entity3 @entity0 with diagnoses of work-related @entity2 were reviewed. For inclusion in the study, @entity0 could have no other @entity1 , they must have completed treatment for the @entity2 , and the etiology of their @entity2 could not be traumatic. A total of 58 @entity0 were included. Those who received conservative treatment followed by surgery (n = 27) were compared with those who were treated with surgery only (n = 31). A chi-square test showed a significant relationship between type of treatment and return to work (chi2(1)=4.065; p=0.044). Of the 31 @entity0 who received only surgical treatment, 83.9% returned to original employment. Of the 27 @entity0 who received both conservative and surgical treatment, 59.1% returned to their original employment. While this is a small sample size, the findings suggest that conservative treatment alone is not effective in @entity3 @entity0 with @entity2 to work.

title: XXXX cases of @entity2 : an outcome study.

answer: @entity3


abstract: The primary goal of this retrospective study was to determine the most effective treatment protocol to @entity3 @entity0 with @entity2 ( @entity2 ) to their original jobs. By examining a homogeneous subject pool and using specific, functional outcome measures determined by what is needed to reduce @entity3 costs, a treatment protocol could be developed benefiting both the employer and employee. A total of 121 charts of @entity3 @entity0 with diagnoses of work-related @entity2 were reviewed. For inclusion in the study, @entity0 could have no other @entity1 , they must have completed treatment for the @entity2 , and the etiology of their @entity2 could not be traumatic. A total of 58 @entity0 were included. Those who received conservative treatment followed by surgery (n = 27) were compared with those who were treated with surgery only (n = 31). A chi-square test showed a significant relationship between type of treatment and return to work (chi2(1)=4.065; p=0.044). Of the 31 @entity0 who received only surgical treatment, 83.9% returned to original employment. Of the 27 @entity0 who received both conservative and surgical treatment, 59.1% returned to their original employment. While this is a small sample size, the findings suggest that conservative treatment alone is not effective in @entity3 @entity0 with @entity2 to work.

title: @entity3 cases of XXXX : an outcome study.

answer: @entity2


abstract: This report investigates an outbreak of acute @entity2 , microbiologically and epidemiologically linked to an aged-care facility and seeks to determine if there was a point source of @entity1 . A register of cases that included onset date and time of illness and symptoms was maintained by nursing staff. Faecal specimens were tested for conventional gastrointestinal pathogens and for @entity0 calicivirus (HuCV). There were 81 cases reported. Specimens were received for testing from 25 cases. Twenty-three of the 25 (92%) specimens were positive for HuCV RNA by reverse transcriptase polymerase chain reaction (RT-PCR). The 2 negative samples contained RT-PCR inhibitors. Descriptive epidemiology suggested that staffing practices were important in prolonging the outbreak. No point source of @entity1 was identified. Instead environmental contamination, aerosol transmission and work practices that fail to take account of the natural history of @entity3 probably contributed to the size (81 cases) and duration (3 weeks) of this outbreak among the residents, staff and visitors of an aged-care facility and their contacts. Institutional outbreaks caused by HuCV, formerly called Norwalk-like or small round structured viruses, are extremely difficult to control. Infected staff may contribute significantly to the amplification of outbreaks. Rapid confirmation of @entity3 is now routinely possible using polymerase chain reaction diagnostics but progress in laboratory technology has not yet translated into faster or more effective interventions.

title: A large, prolonged outbreak of @entity0 XXXX linked to an aged-care facility.

answer: @entity3


abstract: This report investigates an outbreak of acute @entity2 , microbiologically and epidemiologically linked to an aged-care facility and seeks to determine if there was a point source of @entity1 . A register of cases that included onset date and time of illness and symptoms was maintained by nursing staff. Faecal specimens were tested for conventional gastrointestinal pathogens and for @entity0 calicivirus (HuCV). There were 81 cases reported. Specimens were received for testing from 25 cases. Twenty-three of the 25 (92%) specimens were positive for HuCV RNA by reverse transcriptase polymerase chain reaction (RT-PCR). The 2 negative samples contained RT-PCR inhibitors. Descriptive epidemiology suggested that staffing practices were important in prolonging the outbreak. No point source of @entity1 was identified. Instead environmental contamination, aerosol transmission and work practices that fail to take account of the natural history of @entity3 probably contributed to the size (81 cases) and duration (3 weeks) of this outbreak among the residents, staff and visitors of an aged-care facility and their contacts. Institutional outbreaks caused by HuCV, formerly called Norwalk-like or small round structured viruses, are extremely difficult to control. Infected staff may contribute significantly to the amplification of outbreaks. Rapid confirmation of @entity3 is now routinely possible using polymerase chain reaction diagnostics but progress in laboratory technology has not yet translated into faster or more effective interventions.

title: A large, prolonged outbreak of XXXX @entity3 linked to an aged-care facility.

answer: @entity0


abstract: It has now been clearly established that quantitative immunohistochemical methods applied to @entity2 angiogenesis under suitable quality control conditions are a powerful prognostic tool for use in the initial assessment of @entity0 . Appropriate parameters for predicting the @entity3 of @entity2 and their sensitivity to treatment are, however, still required. To determine whether the microvessel count (MVC) may serve to predict the chemotherapeutic response, a retrospective study was carried out on a series of 162 @entity1 with @entity0 , who were all treated with the same standard adjuvant chemotherapy. Angiogenesis was assessed by performing @entity8 immunostaining and MVC per mm2. Several other factors such as @entity5 , @entity7 , @entity4 , and Ki67 were also measured, and their prognostic value was compared with that of the MVC. The MVC was not found to be correlated with any of the other prognostic parameters, but turned out to be of great prognostic value whatever the threshold value chosen, which suggests that it is continuously valid at all levels. The median value of the MVC (43.5 per mm2) divided this series into two significantly different prognostic categories, in terms of both disease-free survival (P = 0.0002) and overall survival (P = 0.037). Univariate analysis showed that most of the parameters analysed were of prognostic value regarding the disease-free survival, namely grade (P = 0.029), mitotic index (P = 0.049), size (P = 0.015), @entity9 receptors (P = 0.022), @entity6 receptors (P = 0.018), @entity5 (P = 0.0045), @entity7 (P = 0.046), and Ki67 (P = 0.0008). As regards overall survival, grade and @entity7 showed a loss of prognostic value. In multivariate analysis on disease-free survival, the MVC was the most accurate prognostic factor (RR = 2.64), followed by Ki67 (RR = 2.06) and @entity5 (RR = 1.69). With respect to overall survival, the MVC ranked third among the prognostic parameters analysed. Standard chemotherapy did not reduce the high prognostic value of the MVC performed on @entity2 angiogenesis. This suggests that the MVC may predict the degree of resistance to chemotherapy. @entity1 with high levels of angiogenesis, particularly node-negative @entity1 , might therefore be able to benefit from adjuvant therapy of another kind.

title: Angiogenesis as a prognostic marker in XXXX with conventional adjuvant chemotherapy: a multiparametric and immunohistochemical analysis.

answer: @entity0


abstract: Three @entity0 , a @entity0 aged 10 and two @entity0 aged 59 and 64 years, had @entity9 , @entity8 ( @entity8 ) and @entity3 ( @entity3 ), respectively. @entity8 and @entity3 are rare illnesses with a high morbidity and mortality. The aetiology is mainly iatrogenic: a hypersensitivity reaction to certain pharmaceutical prescriptions. @entity8 and @entity3 should be differentiated from the more frequent @entity9 , a self-limiting disease without important residual symptoms, which is usually initiated by @entity6 . @entity8 and @entity3 are variants in a spectrum of exfoliative dermatoses with @entity1 . @entity8 and @entity3 on the one hand and @entity9 on the other can be distinguished on the basis of aetiology, clinical symptoms and histopathology. The distinction can, however, be difficult, notably in the early stages. The @entity0 recovered completely. The first @entity0 was treated with @entity5 and also recovered; she was thought to have developed the syndrome as a reaction to malarial prophylactics. The third @entity0 died, despite extensive treatment, of @entity4 and sloughing of 70% of the skin, probably as a reaction to @entity2 given for @entity7 .

title: [ @entity9 . @entity8 and XXXX : an important diagnostic distinction].

answer: @entity3


abstract: Three @entity0 , a @entity0 aged 10 and two @entity0 aged 59 and 64 years, had @entity9 , @entity8 ( @entity8 ) and @entity3 ( @entity3 ), respectively. @entity8 and @entity3 are rare illnesses with a high morbidity and mortality. The aetiology is mainly iatrogenic: a hypersensitivity reaction to certain pharmaceutical prescriptions. @entity8 and @entity3 should be differentiated from the more frequent @entity9 , a self-limiting disease without important residual symptoms, which is usually initiated by @entity6 . @entity8 and @entity3 are variants in a spectrum of exfoliative dermatoses with @entity1 . @entity8 and @entity3 on the one hand and @entity9 on the other can be distinguished on the basis of aetiology, clinical symptoms and histopathology. The distinction can, however, be difficult, notably in the early stages. The @entity0 recovered completely. The first @entity0 was treated with @entity5 and also recovered; she was thought to have developed the syndrome as a reaction to malarial prophylactics. The third @entity0 died, despite extensive treatment, of @entity4 and sloughing of 70% of the skin, probably as a reaction to @entity2 given for @entity7 .

title: [ @entity9 . XXXX and @entity3 : an important diagnostic distinction].

answer: @entity8


abstract: Three @entity0 , a @entity0 aged 10 and two @entity0 aged 59 and 64 years, had @entity9 , @entity8 ( @entity8 ) and @entity3 ( @entity3 ), respectively. @entity8 and @entity3 are rare illnesses with a high morbidity and mortality. The aetiology is mainly iatrogenic: a hypersensitivity reaction to certain pharmaceutical prescriptions. @entity8 and @entity3 should be differentiated from the more frequent @entity9 , a self-limiting disease without important residual symptoms, which is usually initiated by @entity6 . @entity8 and @entity3 are variants in a spectrum of exfoliative dermatoses with @entity1 . @entity8 and @entity3 on the one hand and @entity9 on the other can be distinguished on the basis of aetiology, clinical symptoms and histopathology. The distinction can, however, be difficult, notably in the early stages. The @entity0 recovered completely. The first @entity0 was treated with @entity5 and also recovered; she was thought to have developed the syndrome as a reaction to malarial prophylactics. The third @entity0 died, despite extensive treatment, of @entity4 and sloughing of 70% of the skin, probably as a reaction to @entity2 given for @entity7 .

title: [ XXXX . @entity8 and @entity3 : an important diagnostic distinction].

answer: @entity9


abstract: Survivin is ubiquitously expressed in @entity0 with @entity3 ( @entity3 ) and is associated with poor survival and chemotherapy resistance. @entity9 ( @entity9 ) is a selective survivin suppressant that exhibits potent antitumor activities by inducing apoptosis and autophagy in various types of @entity1 . However, the curative effects and underlying mechanisms of @entity9 in @entity3 remain unclear. This study showed that survivin overexpression positively correlated with p-S6, @entity4 and @entity6 but negatively correlated with the autophagic marker @entity8 in @entity0 @entity3 tissues. In vitro studies revealed that @entity9 triggered apoptosis of @entity3 cells in mitochondria and death receptor-dependent manner. The treatment also significantly enhanced autophagy by upregulating @entity7 , which led to cell death. @entity9 not only downregulated the expression of survivin but also remarkably suppressed the activation of the mTOR signaling pathway in vitro and in vivo. @entity9 displayed potent antitumor activities in both CAL27 xenograft and transgenic @entity3 @entity2 models by delaying @entity1 onset and suppressing @entity1 growth. Furthermore, @entity9 combined with @entity5 promoted @entity1 regression better than either treatment alone without causing considerable body weight loss in the @entity3 xenograft models. Overall, targeting survivin by @entity9 can benefit @entity3 therapy by increasing apoptotic and autophagic cell death, and suppressing prosurvival pathways.

title: Dual induction of apoptotic and autophagic cell death by targeting survivin in XXXX .

answer: @entity3


abstract: We present a technique that allows postoperative adjustment of the sling @entity2 in female @entity0 with @entity3 ( @entity3 ). Twenty-one female @entity0 with urodynamically proven @entity3 were prospectively evaluated. Subjective and objective evaluation was made preoperatively, 6 months postoperatively and yearly thereafter. Mean age was 63.5; mean parity was 2.3. All @entity0 were postmenopausal and 13 (62%) had had previous surgery for @entity3 . The operating time was 32 minutes (range 25-45). At a mean follow-up of 12 months (6-25), 19 @entity0 (90.5%) were very satisfied. Two @entity0 (9.5%) were considered failures but subjectively were satisfied and refused readjustment. One @entity0 (4.7%) developed 'de novo' detrusor instability. In conclusion, this is a sling procedure for @entity0 with previous failed surgery and those with @entity1 ( @entity1 ) with the peculiarity that the sling @entity2 can be regulated postoperatively. The readjustment can be made in the office, months or even years after the procedure.

title: Surgical treatment of XXXX using a method for postoperative adjustment of sling @entity2 (Remeex System).

answer: @entity3


abstract: We present a technique that allows postoperative adjustment of the sling @entity2 in female @entity0 with @entity3 ( @entity3 ). Twenty-one female @entity0 with urodynamically proven @entity3 were prospectively evaluated. Subjective and objective evaluation was made preoperatively, 6 months postoperatively and yearly thereafter. Mean age was 63.5; mean parity was 2.3. All @entity0 were postmenopausal and 13 (62%) had had previous surgery for @entity3 . The operating time was 32 minutes (range 25-45). At a mean follow-up of 12 months (6-25), 19 @entity0 (90.5%) were very satisfied. Two @entity0 (9.5%) were considered failures but subjectively were satisfied and refused readjustment. One @entity0 (4.7%) developed 'de novo' detrusor instability. In conclusion, this is a sling procedure for @entity0 with previous failed surgery and those with @entity1 ( @entity1 ) with the peculiarity that the sling @entity2 can be regulated postoperatively. The readjustment can be made in the office, months or even years after the procedure.

title: Surgical treatment of @entity3 using a method for postoperative adjustment of sling XXXX (Remeex System).

answer: @entity2


abstract: INTRODUCTION: Bone morphogenetic protein (BMP) has been shown to induce bone formation and union in long bone defects and nonunions. There are, however, no previous reports of BMP being used for ulnar nonunions. We report on five cases of resistant ulnar nonunions treated with a composite implant consisting of a biocoral frame, collagen carrier, and @entity3 BMP. MATERIALS AND METHODS: Four diaphyseal and one olecranon ulnar nonunions were treated using BMP/coral implant combined with internal fixation. Additional autografting was used in three cases. All of the cases were challenging in their own ways: Three of the @entity0 had been operated on earlier for their nonunion without success, one had a 40 mm @entity4 , and one had a 9-month-old untreated @entity1 . After excision of the sclerotic surfaces of the nonunion, the gap was filled with autograft and a composite implant containing BMP. Fixation was done with a compression plate in the diaphyseal nonunions and with a tension band in the olecranon nonunion. RESULTS: Solid union was achieved in all five cases. No @entity2 or other adverse effects were encountered. CONCLUSION: These preliminary results suggest that BMP-containing implants might be a feasible alternative or superior to autografting in the treatment of resistant ulnar nonunions.

title: Composite implant of native XXXX bone morphogenetic protein (BMP), collagen carrier and biocoral in the treatment of resistant ulnar nonunions: report of five preliminary cases.

answer: @entity3


abstract: To evaluate the helical CT findings of @entity2 ( @entity2 ), 12 @entity0 with @entity2 were reviewed with regard to the @entity1 's location, size and contour protrusion, the appearance of the mass, the enhancement pattern, multiplicity and secondary changes. All @entity1 were located at the periphery of the liver and had a protruding contour. The maximum diameter of @entity1 ranged from 2 cm to 16 cm. Discontinuity of the hepatic surface was seen in 11 cases. In eight cases, CT images during the arterial phase showed a non-enhancing low attenuating lesion with focal discontinuity and peripheral rim enhancement. Seven cases showed @entity1 content from the peripheral enhancing rim and intraperitoneal @entity1 content into the perihepatic space. Because of the similar appearance to an enucleated orbital globe with remaining sclera, this was termed the "enucleation sign". As well as ruptured masses, 10 cases with non-ruptured masses also showed a non-enhancing low attenuating pattern. Seven cases showed a haematoma with high attenuation around the ruptured mass. The peripheral location, protruding contour, discontinuity of the hepatic surface and surrounding haematoma are helpful signs in the diagnosis of @entity2 . The "enucleation sign" may be a characteristic finding in @entity2 .

title: The findings of XXXX on helical CT.

answer: @entity2


abstract: Socioeconomic factors cannot entirely explain why black @entity1 have an earlier age of @entity0 onset and higher mortality rates, stage for stage, than whites. We and others have shown that @entity5 [PSA, also known as @entity1 @entity8 (hK) 3] is a marker of breast as well as @entity3 , that @entity6 and @entity7 are highly homologous at the DNA and protein level and that the level of @entity4 , which appears to upregulate @entity7 , is influenced by ethnicity. We hypothesized that nipple aspiration fluid (NAF) @entity6 and @entity7 levels are (i) lower in black than white @entity1 ; (ii) independently associated with @entity0 ; (iii) influenced by menopausal status; and (iv) in combination are more informative about whether a @entity1 has @entity0 than either marker alone. NAF was assayed for @entity6 and @entity7 , and the results were stratified by ethnicity, presence or absence of @entity2 and menopausal status. Statistical analysis was then performed. When stratified by ethnicity, @entity6 (p = 0.003) and @entity7 (p = 0.027) levels in blacks were lower than in whites. @entity6 was lower in premenopausal black than in white subjects, regardless of @entity2 status. Overall, @entity6 , @entity7 and the ratio @entity6 / @entity7 were lower in subjects with @entity0 than in normal subjects. @entity7 was lower in postmenopausal @entity1 with @entity0 , regardless of ethnicity. @entity6 and @entity7 levels were higher in pre- than in postmenopausal whites. Using logistic regression and considering @entity6 , @entity7 , @entity6 / @entity7 and ethnicity, @entity7 was significantly associated with @entity0 in both pre- (p < 0.001) and postmenopausal @entity1 (p = 0.023). In conclusion, whereas @entity6 , @entity7 , @entity6 / @entity7 and ethnicity are each significantly associated with @entity0 bivariately, after entering the strongest predictor, @entity7 , into a logistic regression model, no other variable accounted for additional variation, although this observation is preliminary due to the limited number of black subjects in the study.

title: Ethnic variation in XXXX expression in nipple aspirate fluid.

answer: @entity8


abstract: BACKGROUND: Metallothioneins (MT) are low-molecular weight, metal-binding proteins that play a role in cellular proliferation and differentiation, as well as in cellular defense mechanisms. They act as scavengers of free radicals produced by irradiation. A number of in vitro and in vivo studies have linked overexpression of cellular MT with @entity1 cell resistance to radiation. This is the first study that investigates whether MT expression is involved in the radioresistance of @entity2 . METHODS: Using a mouse monoclonal antibody, MT expression was analyzed by immunohistochemistry on surgical samples (n = 85) from 85 @entity0 with locally advanced @entity2 who were treated preoperatively with a hyperfractionated and accelerated radiotherapy schedule and on @entity1 biopsies (n = 13) obtained before treatment. The potential correlations between MT expression and pathologic variables and survival were examined. RESULTS: MT were expressed strongly in both the cytoplasm and nucleus of @entity1 cells in 7 biopsy and 42 surgical samples. A comparison of MT expression in biopsy and surgical specimens showed that MT expression did not change after irradiation in most cases. Against all expectations, MT were expressed more frequently in @entity1 from responders than in those from the nonresponders (P = 0.02). There was no correlation between MT expression and @entity1 stage, histology after radiotherapy, or survival. CONCLUSION: These findings do not Cansupport the hypothesis that MT overexpression at the end of radiotherapy is a marker for radiation resistance.

title: Role of metallothioneins in irradiated @entity0 XXXX .

answer: @entity2


abstract: BACKGROUND: Metallothioneins (MT) are low-molecular weight, metal-binding proteins that play a role in cellular proliferation and differentiation, as well as in cellular defense mechanisms. They act as scavengers of free radicals produced by irradiation. A number of in vitro and in vivo studies have linked overexpression of cellular MT with @entity1 cell resistance to radiation. This is the first study that investigates whether MT expression is involved in the radioresistance of @entity2 . METHODS: Using a mouse monoclonal antibody, MT expression was analyzed by immunohistochemistry on surgical samples (n = 85) from 85 @entity0 with locally advanced @entity2 who were treated preoperatively with a hyperfractionated and accelerated radiotherapy schedule and on @entity1 biopsies (n = 13) obtained before treatment. The potential correlations between MT expression and pathologic variables and survival were examined. RESULTS: MT were expressed strongly in both the cytoplasm and nucleus of @entity1 cells in 7 biopsy and 42 surgical samples. A comparison of MT expression in biopsy and surgical specimens showed that MT expression did not change after irradiation in most cases. Against all expectations, MT were expressed more frequently in @entity1 from responders than in those from the nonresponders (P = 0.02). There was no correlation between MT expression and @entity1 stage, histology after radiotherapy, or survival. CONCLUSION: These findings do not Cansupport the hypothesis that MT overexpression at the end of radiotherapy is a marker for radiation resistance.

title: Role of metallothioneins in irradiated XXXX @entity2 .

answer: @entity0


abstract: BACKGROUND: The progressively increasing number of long-term survivors after allogeneic bone marrow transplantation (allo-BMT) led researchers to focus on the early and late complications of this procedure. Endocrine dysfunction occurred mostly in @entity0 who had undergone total body irradiation (TBI) as part of pretransplantation treatment. The extent to which chemotherapy and immune system derangement affect endocrine function in allo-BMT recipients is still unclear. METHODS: Forty consecutive @entity0 (21 @entity0 , 19 @entity0 ) with @entity6 surviving 12 or more months after allo-BMT from HLA-identical siblings were studied. @entity0 ' age at transplantation ranged from 13 to 45 years and their post-BMT follow-up lasted 12-62 months. The conditioning regimen BUCY2 was employed. @entity7 ( @entity7 ) was observed in the acute form in 13 @entity0 and in the chronic form in 26. The function of hypothalamic-pituitary-gonad, thyroid, somatotrophic, and adrenal axes was assessed. RESULTS: The most common @entity9 was @entity12 (95% of @entity0 ), followed by an increase in follicle-stimulating hormone in 47% of @entity0 , indicating spermatogenesis damage. @entity10 replacement therapy was contraindicated in three @entity0 because of chronic liver @entity7 and it was ineffective partially in four others because of reduced intestinal or cutaneous absorption. @entity3 occurred in 47.5% of @entity0 and included @entity8 , @entity11 , and transient @entity5 and @entity4 . Adrenal function was abnormal in 10%, mostly related to the prolonged corticosteroid treatment. @entity2 was lower than age-reference values in 27% of all @entity0 and in 38% of those with chronic @entity7 . Thyroid, adrenal, and @entity2 impairments were more frequent in @entity0 with chronic @entity7 than in @entity0 without this disease (P = 0.048). CONCLUSIONS: A high prevalence of @entity9 was detected in a cohort of allo-BMT recipients not treated by TBI. Although @entity1 was likely related to intensive myeloablative treatments, thyroid, adrenal, and @entity2 impairments were late events, suggesting that immunosuppressive treatment and immune system derangement may play a role in the development of @entity9 after allografting.

title: High prevalence of XXXX in long-term survivors after allogeneic bone marrow transplantation for @entity6 .

answer: @entity9


abstract: BACKGROUND: The progressively increasing number of long-term survivors after allogeneic bone marrow transplantation (allo-BMT) led researchers to focus on the early and late complications of this procedure. Endocrine dysfunction occurred mostly in @entity0 who had undergone total body irradiation (TBI) as part of pretransplantation treatment. The extent to which chemotherapy and immune system derangement affect endocrine function in allo-BMT recipients is still unclear. METHODS: Forty consecutive @entity0 (21 @entity0 , 19 @entity0 ) with @entity6 surviving 12 or more months after allo-BMT from HLA-identical siblings were studied. @entity0 ' age at transplantation ranged from 13 to 45 years and their post-BMT follow-up lasted 12-62 months. The conditioning regimen BUCY2 was employed. @entity7 ( @entity7 ) was observed in the acute form in 13 @entity0 and in the chronic form in 26. The function of hypothalamic-pituitary-gonad, thyroid, somatotrophic, and adrenal axes was assessed. RESULTS: The most common @entity9 was @entity12 (95% of @entity0 ), followed by an increase in follicle-stimulating hormone in 47% of @entity0 , indicating spermatogenesis damage. @entity10 replacement therapy was contraindicated in three @entity0 because of chronic liver @entity7 and it was ineffective partially in four others because of reduced intestinal or cutaneous absorption. @entity3 occurred in 47.5% of @entity0 and included @entity8 , @entity11 , and transient @entity5 and @entity4 . Adrenal function was abnormal in 10%, mostly related to the prolonged corticosteroid treatment. @entity2 was lower than age-reference values in 27% of all @entity0 and in 38% of those with chronic @entity7 . Thyroid, adrenal, and @entity2 impairments were more frequent in @entity0 with chronic @entity7 than in @entity0 without this disease (P = 0.048). CONCLUSIONS: A high prevalence of @entity9 was detected in a cohort of allo-BMT recipients not treated by TBI. Although @entity1 was likely related to intensive myeloablative treatments, thyroid, adrenal, and @entity2 impairments were late events, suggesting that immunosuppressive treatment and immune system derangement may play a role in the development of @entity9 after allografting.

title: High prevalence of @entity9 in long-term survivors after allogeneic bone marrow transplantation for XXXX .

answer: @entity6


abstract: BACKGROUND: @entity10 ) infection of @entity2 cells results in viral replication with cell destruction and liberation of progeny virion that infect adjacent @entity2 cells. rRp450 is a novel replication-conditional @entity10 mutant that expresses both the endogenous herpes viral @entity9 kinase gene and the @entity4 @entity12 CYP2B1 transgene; @entity12 bioactivates such @entity2 prodrugs as @entity8 . METHODS: @entity6 and replication assays were performed in @entity7 cells as well as primary @entity0 hepatocytes. For in vivo studies, diffuse liver @entity1 were generated by inoculating MC26 cells into the portal system of BALB/c @entity3 . @entity3 were treated with control media, rRp450, or rRp450 plus @entity8 . RESULTS: Cytopathic effects induced by rRp450 replication in @entity7 cells were equivalent to those induced by wild type @entity10 in vitro. Assays developed to separate @entity6 mediated by viral replication from @entity6 mediated by chemotherapy confirmed that @entity10 @entity9 kinase bioactivates @entity11 and CYP2B1 bioactivates @entity8 in rRp450-infected cells. rRp450 mediated @entity6 in the presence of @entity8 was increased by 21% to 30% above that achieved by viral replication alone. @entity8 bioactivation produced bystander killing of @entity7 cells but not hepatocytes. In contrast to these effects of @entity8 , rRp450 mediated @entity6 was reduced in the presence of @entity11 . These findings are explained by further experiments showing that bioactivation of @entity8 only minimally affected @entity10 replication in @entity7 cells, whereas bioactivation of @entity11 markedly attenuated @entity10 replication. In vivo studies revealed a substantial decrease in @entity5 burden in all rRp450-treated animals compared to controls. The addition of @entity8 augmented rRp450's in vivo anti-neoplastic effect. CONCLUSIONS: The rRp450 mutant @entity10 is highly oncolytic against @entity7 cells both in vitro and in vivo. rRp450 displays preferential replication in @entity7 cells compared to normal hepatocytes. Activation of @entity8 by the @entity12 transgene augmented the anti-neoplastic effects of rRp450 without simultaneously decreasing viral replication. Oncolysis induced by @entity10 replication combined with @entity8 prodrug activation warrants further investigation as a potential therapy for @entity7 liver @entity1 .

title: Prodrug bioactivation and oncolysis of diffuse liver XXXX by a @entity10 mutant that expresses the CYP2B1 transgene.

answer: @entity1


abstract: BACKGROUND: @entity10 ) infection of @entity2 cells results in viral replication with cell destruction and liberation of progeny virion that infect adjacent @entity2 cells. rRp450 is a novel replication-conditional @entity10 mutant that expresses both the endogenous herpes viral @entity9 kinase gene and the @entity4 @entity12 CYP2B1 transgene; @entity12 bioactivates such @entity2 prodrugs as @entity8 . METHODS: @entity6 and replication assays were performed in @entity7 cells as well as primary @entity0 hepatocytes. For in vivo studies, diffuse liver @entity1 were generated by inoculating MC26 cells into the portal system of BALB/c @entity3 . @entity3 were treated with control media, rRp450, or rRp450 plus @entity8 . RESULTS: Cytopathic effects induced by rRp450 replication in @entity7 cells were equivalent to those induced by wild type @entity10 in vitro. Assays developed to separate @entity6 mediated by viral replication from @entity6 mediated by chemotherapy confirmed that @entity10 @entity9 kinase bioactivates @entity11 and CYP2B1 bioactivates @entity8 in rRp450-infected cells. rRp450 mediated @entity6 in the presence of @entity8 was increased by 21% to 30% above that achieved by viral replication alone. @entity8 bioactivation produced bystander killing of @entity7 cells but not hepatocytes. In contrast to these effects of @entity8 , rRp450 mediated @entity6 was reduced in the presence of @entity11 . These findings are explained by further experiments showing that bioactivation of @entity8 only minimally affected @entity10 replication in @entity7 cells, whereas bioactivation of @entity11 markedly attenuated @entity10 replication. In vivo studies revealed a substantial decrease in @entity5 burden in all rRp450-treated animals compared to controls. The addition of @entity8 augmented rRp450's in vivo anti-neoplastic effect. CONCLUSIONS: The rRp450 mutant @entity10 is highly oncolytic against @entity7 cells both in vitro and in vivo. rRp450 displays preferential replication in @entity7 cells compared to normal hepatocytes. Activation of @entity8 by the @entity12 transgene augmented the anti-neoplastic effects of rRp450 without simultaneously decreasing viral replication. Oncolysis induced by @entity10 replication combined with @entity8 prodrug activation warrants further investigation as a potential therapy for @entity7 liver @entity1 .

title: Prodrug bioactivation and oncolysis of diffuse liver @entity1 by a XXXX mutant that expresses the CYP2B1 transgene.

answer: @entity10


abstract: OBJECTIVES: To assess the pathology of @entity3 and to determine whether @entity2 of the @entity4 occurs more often among whites than among other ethnic groups in Hawaii. This study focuses on demographic differences in subsite locations and histologic types of @entity3 . METHODS: We reviewed 532 sequential gastric @entity2 accessioned between 1993 and 1999 in the Hawaii Tumor Registry. Pathology reports and slides were reviewed by the study pathologist. RESULTS: @entity2 of the @entity4 occurred in 51 (15.8%) of 323 males compared with 18 (8.6%) of 209 females (P = 0.02, after age adjustment). The age-adjusted percent of @entity4 cases was 41.8% for Hawaiian white males compared with 13.4% for @entity0 of all other ethnic groups (P = 0.0002). The age-adjusted percent of @entity4 cases was 22.4% for Hawaiian white females compared with 7.3% for females of other groups. (P = 0.08). At all age levels, females had more frequent diffuse @entity2 and less frequent @entity3 than @entity0 . The age-adjusted percent with diffuse @entity2 was 35.3% for females and 13.7% for males (P < 0.0001). Also, the sex-adjusted percent with diffuse @entity2 was 26.0% for @entity0 younger than 75 years of age compared with 17.0% for @entity0 75 years or older (P = 0.01). Conversely, the sex-adjusted percent with @entity6 was 67.9% for @entity0 younger than 75 years of age compared with 77.1% for @entity0 75 years or older (P = 0.02). The proportion of cases showing precursor lesions (intestinal metaplasia or superficial @entity5 ) increased progressively with the distance of the @entity2 from the @entity4 . CONCLUSIONS: @entity2 of the @entity4 is predominantly a @entity1 of white males and is not associated with the multifocal @entity5 characteristically found with @entity2 . Diffuse @entity3 shows no ethnic predilection, but expression of this phenotype is clearly related to the age and gender of the @entity0 .

title: XXXX : pathology findings in a multiethnic population.

answer: @entity3


abstract: Most reports of outcome following @entity1 surgery report weight and co-morbidity changes only. We studied body composition changes in 17 adult @entity0 (15 F, 2 M, age 43+/-2 years, range 28-58 years), with morbid @entity1 (initial BMI 40.4+/-4.9 kg/m(2), range 34.7-48.8) who were managed surgically by laparoscopically inserting an adjustable gastric band. Body composition was studied before and after surgery (mean interval of 909+/-51 days, range 441-1155 days) using anthropometry (abdominal circumference, AC, sum of four skinfold thicknesses, SFSUM), whole-body @entity3 counting (TBK), in vivo neutron activation analysis total body @entity4 (TBProtein) and whole-body dual-energy ray absorptiometry (total body percent fat TBF%, and total body bone mineral density TBBMD). Weight loss over the study period was 23.4+/-2.5 kg. ( p<0.0003) with an AC reduction of 20.0+/-4.5 cm ( p<0.008). Both SFSUM and TBF% were significantly reduced ( p<0.02 and p<0.0005 respectively). Both TBK and TBProtein after normalization for sex and height, were significantly ( p<0.0054 and p<0.001 respectively) reduced, but the ratio of loss of fat mass to fat-free mass, at 4.4:1 was usual for @entity2 , and there was no significant changes in the ratio of @entity3 to protein. TBBMD, after normalization relative to a young same sex adult, was not significantly changed. In this group of @entity0 , most of the substantial @entity2 over a 2- to 3-year period was due to loss of fat mass, with relatively less reduction in the components of fat-free mass. Adjustable laparoscopic gastric banding induces fat loss without significant other deleterious effects on body composition.

title: Body composition changes following laparoscopic gastric banding for morbid XXXX .

answer: @entity1


abstract: BACKGROUND: During the last 20 years, survival rates of @entity2 @entity0 in the United States and Europe have plateaued. To determine the factors that can reduce mortality rates, we examined changes in clinical presentation and survival rates across 24 years of treatment of @entity2 @entity0 . METHODS: A retrospective study of @entity0 with @entity2 was conducted from January 1, 1975, to December 31, 1998. We identified 2143 eligible @entity0 with @entity4 , oropharynx, hypopharynx, and larynx. Changes in gender, clinical stage, and therapy were evaluated separately for each site of @entity1 across five consecutive periods. Probability of dying and overall survival rates were estimated. Odds ratios (ORs) and hazard ratios were calculated. RESULTS: An increase in T1 versus T2 or higher stage @entity3 was more probable for the oral cavity and larynx (OR = 4.1 and 3.0, respectively) in the last versus the earliest period. An increase in radical treatments was more probable for @entity3 of the oral cavity, oropharynx, hypopharynx, and larynx (10.2, 34.8, 12.5, and 2.1-fold, respectively) in the last versus the earliest period. A decreasing trend of probability of dying from the first @entity2 during the 1970s versus the 1990s was found. The overall survival rates at 5 years was 32% in 1975-1978 versus 51% in 1989-1993. CONCLUSIONS: In contrast with survival rates in the United States and Europe, our findings show a significant increase in overall survival rates during the last 20 years. This increase is attributable to changes in diagnostic-therapeutic approaches and to early consultation with a physician for symptoms arising in the head and neck region.

title: Changes in presentation and survival of XXXX in Northeastern Italy, 1975-1998.

answer: @entity2


abstract: The expression of the angiotensin-forming enzymes, @entity2 and angiotensin-converting enzyme ( @entity1 ), were examined in the @entity0 uteroplacental unit. The @entity1 activity was determined in cell membrane fractions, and @entity1 and @entity2 were localized by autoradiography and immunohistochemistry, respectively. In the myometrium, the @entity1 activity was significantly higher in dioestrous than in oestrous. @entity1 activity correlated negatively with the day of gestation in the endometrium and myometrium but positively in the placentome and allantoamniotic membrane. Autoradiography showed, that @entity1 was localized in vascular endothelial cells in all compartments. @entity1 was also expressed in the endometrial stroma and uterine glands, most pronounced in the outer part of the basal zone. In the intercotyledonary membrane and the placentome, the mesenchymal cells located near the trophoblast cells expressed @entity1 . Solitary macrophage- or monocyte-like cells showing intense @entity2 immunoreactivity were found in the uterus, while the uterine and the glandular epithelial cells displayed inconsistent reactivity. No @entity2 was observed in the placentomes or in the fetal membranes. The findings demonstrate a regulated expression of angiotensin-forming enzymes throughout the @entity0 uteroplacental unit. Whether this local @entity2 -angiotensin system contributes to the highly regulated morphological and functional changes throughout the oestrous cycle and gestation remains to be established.

title: Angiotensin-converting enzyme activity in the XXXX uteroplacental unit changes in relation to the cycle and pregnancy.

answer: @entity0


abstract: BACKGROUND: The daily use of either intranasal corticosteroids or @entity2 (1) (H(1)) receptor antagonists has proved to be efficacious in the treatment of @entity4 . Most @entity0 , however, use these medications as needed. Our objective was to compare the effectiveness of as-needed use of H(1) receptor antagonists with that of intranasal corticosteroids in the treatment of @entity4 . METHODS: We performed a randomized, open-label, parallel-group study comparing the as-needed use of an H(1) receptor antagonist ( @entity5 ) with that of an intranasal @entity3 ( @entity6 ) in the management of fall @entity4 in the fall of 1999. Subjects kept a diary of their daily symptoms and were examined at enrollment into the study and biweekly for 4 weeks during treatment. Outcome measures were the @entity7 Quality of Life Questionnaire score, daily symptom diary scores, and the number of eosinophils and the levels of eosinophilic cationic protein in nasal lavage samples. RESULTS: @entity0 in the @entity6 -treated group reported significantly better scores in the activity, sleep, practical, nasal, and overall domains (P<.05) of the @entity7 Quality of Life Questionnaire. The median total symptom score in the @entity6 -treated group was significantly lower than that in the @entity5 -treated group (4.0 vs 7.0; P<.01). After treatment, the number of eosinophils was significantly smaller in the @entity6 -treated group compared with the @entity5 -treated group (P =.001). Eosinophilic cationic protein levels followed the same pattern, with a significant correlation between the levels of eosinophilic cationic protein and the number of eosinophils (r(s) = 0.70, P<.01). CONCLUSION: As-needed intranasal corticosteroids reduce @entity1 and are more effective than as-needed H(1) receptor antagonists in the treatment of @entity4 .

title: Superiority of an intranasal corticosteroid compared with an oral antihistamine in the as-needed treatment of XXXX .

answer: @entity4


abstract: BACKGROUND: @entity1 @entity0 suffer from the progressive deterioration of cognitive and functional abilities. @entity2 usually appear in the earlier stages of the disease while basic disabilities appear in the more advanced stages. In order to differentiate between mild, moderate and severe @entity0 both @entity2 should be taken into account simultaneously. OBJECTIVES: The objective of this study was to find a new method for classifying @entity1 @entity0 based on their disabilities by using a basic and an instrumental Activities of Daily Living (ADL) scale. METHODS: Functional disability was assessed in a Belgian cohort of @entity1 @entity0 using the Katz and Lawton Instrumental Activities of Daily Living (IADL) scales. A k-means derived clustering method allocated @entity0 to disability clusters according to their Katz and Lawton scores. In order to validate the classification, we compared socio-demographic, clinical and costs parameters between the groups. RESULTS: The clustering method allocated @entity0 between three clusters: dependent, non-dependent with @entity2 (ND-IFD) and non-dependent. @entity3 , as defined by these clusters, significantly correlates with age, residential setting, MMSE, @entity0 's quality of life and costs. CONCLUSION: This new classification of @entity0 suffering from @entity1 will provide better understanding of functional disabilities and will complement the evaluation of disease severity based on cognitive function.

title: A new approach to the qualitative evaluation of functional disability in XXXX .

answer: @entity1


abstract: The pericardial organs (POs) are a pair of neurosecretory organs that surround the crustacean heart and release neuromodulators into the hemolymph. In adult crustaceans, the POs are known to contain a wide array of peptide and @entity3 modulators. However, little is known about the modulatory content of POs early in development. We characterize the morphology and modulatory content of pericardial organs in the embryonic lobster, @entity4 . The POs are well developed by midway through embryonic (E50) life and contain a wide array of neuromodulatory substances. Immunoreactivities to orcokinin, extended @entity5 peptides, @entity1 hydroxylase, @entity6 , @entity7 , @entity0 , Cancer borealis @entity2 -related peptide, cholecystokinin, and crustacean cardioactive peptide are present in the POs by approximately midway through embryonic life. There are two classes of projection patterns to the POs. Immunoreactivities to orcokinin, extended @entity5 peptides, and @entity1 hydroxylase project solely from the subesophageal ganglion (SEG), whereas the remaining modulators project from the SEG as well as from the thoracic ganglia. Double-labeling experiments with a subset of modulators did not reveal any colocalized peptides in the POs. These results suggest that the POs could be a major source of neuromodulators early in development.

title: Neuromodulatory complement of the pericardial organs in the embryonic lobster, XXXX .

answer: @entity4


abstract: Trefoil factor family (TFF) domain peptides consist of three members that play a @entity2 and repair, and in tumourigenesis. The role of the three TFF members in the @entity3 cascade remains poorly defined. This study examined seven gastric cell lines, 50 @entity3 and their adjacent non- @entity1 tissues, and tissues from 40 non- @entity1 @entity0 , in order to elucidate the chronology of TFF expression in various stages of @entity3 . TFF expression was determined by RT-PCR, immunohistochemistry, and western blot. Aberrant expression of @entity5 , @entity6 , and @entity7 was frequently detected in gastric cell lines. Specifically, @entity5 was detected in all non- @entity1 @entity0 , but was detected in only 50% of @entity3 and 66% of adjacent normal tissues. @entity6 expression was demonstrated in 87.5% of non- @entity1 @entity0 , 34% of @entity3 , and 58% of adjacent non- @entity1 tissues. There was a significant correlation between @entity5 and @entity6 expression in @entity3 and adjacent non- @entity1 tissues (p<0.001). By contrast, @entity7 was detected in 25% of non- @entity1 @entity0 and showed a predilection for areas with @entity4 (p=0.005). Sixty-two per cent of @entity3 and 24% of neighbouring non- @entity1 tissues showed @entity7 expression. Immunoreactivity against @entity7 was demonstrated in goblet cells of @entity4 and within the cytoplasm and nuclei of @entity1 cells. Progressive loss of @entity5 and @entity6 , together with the induction of @entity7 , is likely to be involved in the early stage of the multi-step @entity3 pathway.

title: Expression of trefoil peptides ( @entity5 , XXXX , and @entity7 ) in @entity3 , @entity4 , and non-neoplastic gastric tissues.

answer: @entity6


abstract: Trefoil factor family (TFF) domain peptides consist of three members that play a @entity2 and repair, and in tumourigenesis. The role of the three TFF members in the @entity3 cascade remains poorly defined. This study examined seven gastric cell lines, 50 @entity3 and their adjacent non- @entity1 tissues, and tissues from 40 non- @entity1 @entity0 , in order to elucidate the chronology of TFF expression in various stages of @entity3 . TFF expression was determined by RT-PCR, immunohistochemistry, and western blot. Aberrant expression of @entity5 , @entity6 , and @entity7 was frequently detected in gastric cell lines. Specifically, @entity5 was detected in all non- @entity1 @entity0 , but was detected in only 50% of @entity3 and 66% of adjacent normal tissues. @entity6 expression was demonstrated in 87.5% of non- @entity1 @entity0 , 34% of @entity3 , and 58% of adjacent non- @entity1 tissues. There was a significant correlation between @entity5 and @entity6 expression in @entity3 and adjacent non- @entity1 tissues (p<0.001). By contrast, @entity7 was detected in 25% of non- @entity1 @entity0 and showed a predilection for areas with @entity4 (p=0.005). Sixty-two per cent of @entity3 and 24% of neighbouring non- @entity1 tissues showed @entity7 expression. Immunoreactivity against @entity7 was demonstrated in goblet cells of @entity4 and within the cytoplasm and nuclei of @entity1 cells. Progressive loss of @entity5 and @entity6 , together with the induction of @entity7 , is likely to be involved in the early stage of the multi-step @entity3 pathway.

title: Expression of trefoil peptides ( @entity5 , @entity6 , and @entity7 ) in XXXX , @entity4 , and non-neoplastic gastric tissues.

answer: @entity3


abstract: Trefoil factor family (TFF) domain peptides consist of three members that play a @entity2 and repair, and in tumourigenesis. The role of the three TFF members in the @entity3 cascade remains poorly defined. This study examined seven gastric cell lines, 50 @entity3 and their adjacent non- @entity1 tissues, and tissues from 40 non- @entity1 @entity0 , in order to elucidate the chronology of TFF expression in various stages of @entity3 . TFF expression was determined by RT-PCR, immunohistochemistry, and western blot. Aberrant expression of @entity5 , @entity6 , and @entity7 was frequently detected in gastric cell lines. Specifically, @entity5 was detected in all non- @entity1 @entity0 , but was detected in only 50% of @entity3 and 66% of adjacent normal tissues. @entity6 expression was demonstrated in 87.5% of non- @entity1 @entity0 , 34% of @entity3 , and 58% of adjacent non- @entity1 tissues. There was a significant correlation between @entity5 and @entity6 expression in @entity3 and adjacent non- @entity1 tissues (p<0.001). By contrast, @entity7 was detected in 25% of non- @entity1 @entity0 and showed a predilection for areas with @entity4 (p=0.005). Sixty-two per cent of @entity3 and 24% of neighbouring non- @entity1 tissues showed @entity7 expression. Immunoreactivity against @entity7 was demonstrated in goblet cells of @entity4 and within the cytoplasm and nuclei of @entity1 cells. Progressive loss of @entity5 and @entity6 , together with the induction of @entity7 , is likely to be involved in the early stage of the multi-step @entity3 pathway.

title: Expression of trefoil peptides ( XXXX , @entity6 , and @entity7 ) in @entity3 , @entity4 , and non-neoplastic gastric tissues.

answer: @entity5


abstract: Trefoil factor family (TFF) domain peptides consist of three members that play a @entity2 and repair, and in tumourigenesis. The role of the three TFF members in the @entity3 cascade remains poorly defined. This study examined seven gastric cell lines, 50 @entity3 and their adjacent non- @entity1 tissues, and tissues from 40 non- @entity1 @entity0 , in order to elucidate the chronology of TFF expression in various stages of @entity3 . TFF expression was determined by RT-PCR, immunohistochemistry, and western blot. Aberrant expression of @entity5 , @entity6 , and @entity7 was frequently detected in gastric cell lines. Specifically, @entity5 was detected in all non- @entity1 @entity0 , but was detected in only 50% of @entity3 and 66% of adjacent normal tissues. @entity6 expression was demonstrated in 87.5% of non- @entity1 @entity0 , 34% of @entity3 , and 58% of adjacent non- @entity1 tissues. There was a significant correlation between @entity5 and @entity6 expression in @entity3 and adjacent non- @entity1 tissues (p<0.001). By contrast, @entity7 was detected in 25% of non- @entity1 @entity0 and showed a predilection for areas with @entity4 (p=0.005). Sixty-two per cent of @entity3 and 24% of neighbouring non- @entity1 tissues showed @entity7 expression. Immunoreactivity against @entity7 was demonstrated in goblet cells of @entity4 and within the cytoplasm and nuclei of @entity1 cells. Progressive loss of @entity5 and @entity6 , together with the induction of @entity7 , is likely to be involved in the early stage of the multi-step @entity3 pathway.

title: Expression of trefoil peptides ( @entity5 , @entity6 , and @entity7 ) in @entity3 , XXXX , and non-neoplastic gastric tissues.

answer: @entity4


abstract: Trefoil factor family (TFF) domain peptides consist of three members that play a @entity2 and repair, and in tumourigenesis. The role of the three TFF members in the @entity3 cascade remains poorly defined. This study examined seven gastric cell lines, 50 @entity3 and their adjacent non- @entity1 tissues, and tissues from 40 non- @entity1 @entity0 , in order to elucidate the chronology of TFF expression in various stages of @entity3 . TFF expression was determined by RT-PCR, immunohistochemistry, and western blot. Aberrant expression of @entity5 , @entity6 , and @entity7 was frequently detected in gastric cell lines. Specifically, @entity5 was detected in all non- @entity1 @entity0 , but was detected in only 50% of @entity3 and 66% of adjacent normal tissues. @entity6 expression was demonstrated in 87.5% of non- @entity1 @entity0 , 34% of @entity3 , and 58% of adjacent non- @entity1 tissues. There was a significant correlation between @entity5 and @entity6 expression in @entity3 and adjacent non- @entity1 tissues (p<0.001). By contrast, @entity7 was detected in 25% of non- @entity1 @entity0 and showed a predilection for areas with @entity4 (p=0.005). Sixty-two per cent of @entity3 and 24% of neighbouring non- @entity1 tissues showed @entity7 expression. Immunoreactivity against @entity7 was demonstrated in goblet cells of @entity4 and within the cytoplasm and nuclei of @entity1 cells. Progressive loss of @entity5 and @entity6 , together with the induction of @entity7 , is likely to be involved in the early stage of the multi-step @entity3 pathway.

title: Expression of trefoil peptides ( @entity5 , @entity6 , and XXXX ) in @entity3 , @entity4 , and non-neoplastic gastric tissues.

answer: @entity7


abstract: The oesophageal-tracheal Combitube (Kendall-Sheridan Catheter Corp., Argyle, NY) is a device designed for difficult airways and @entity2 intubation. The manufacturer recommends that the Combitube size 37F SA be used in @entity0 with a height of between 122 and 152 cm. The aim of this study was to evaluate whether ventilation is effective and reliable in anaesthetized @entity0 taller than 152 cm using the size 37F SA in the oesophageal position. We also evaluated whether airway protection is adequate and whether direct intubation of the @entity3 with the Combitube inserted in the oesophagus is possible. We studied 15 adult @entity0 undergoing routine general anaesthesia and 20 @entity0 who required @entity2 intubation following @entity1 . They were between 150 and 180 cm in height. Under direct vision, a size 37F SA Combitube was inserted into the oesophagus of all the @entity0 undergoing routine general anaesthesia (control group). Blind insertion was performed in the @entity2 @entity0 ( @entity2 group). The pharyngeal balloon was inflated with a volume titrated to air leak and cuff pressures were measured. During surgery, a laryngoscope was inserted into the pharynx with the pharyngeal balloon deflated and the laryngoscopic view was evaluated using the Cormack-Lehane scale. Ventilation was effective and reliable in all 35 @entity0 who were between 150 and 180 cm in height. In addition, a direct relationship between the pharyngeal balloon volume and @entity0 height was established (P<0.05), using linear regression models. The laryngoscopic view of the glottis was adequate to allow direct tracheal intubation in @entity0 in the control group, so that the Combitube size 37F SA may be used in @entity0 from 122 to 185 cm in height. The @entity3 could be directly intubated with the Combitube in the oesophageal position in @entity0 with normal airways and in @entity0 involved in @entity1 . In all @entity0 in the @entity2 group, blind insertion of the Combitube resulted in the device being placed in the oesophagus. The airway protection appears to be adequate.

title: Airway management with the Combitube during anaesthesia and in an XXXX .

answer: @entity2


abstract: OBJECTIVES: The purpose of this study was to determine and compare the efficacy of biphasic and monophasic waveforms in a porcine model of @entity2 . BACKGROUND: The efficacy and safety of biphasic waveforms in @entity0 has not been established. METHODS: We initially studied 27 piglets: 12 weighed 3-6 kg (' @entity0 '), and 15 weighed 7-12 kg (' @entity0 '). @entity1 ( @entity1 ) was induced by rapid right ventricular pacing and maintained for 15 s. Transthoracic shocks of 7-100 J energy were given using monophasic (5 ms truncated exponential) and biphasic (5 ms positive, 5 ms negative pulse, truncated exponential) waveforms. A second study of four ' @entity0 ' and four ' @entity0 ' piglets utilized the same protocol but with a 10 ms instead of 5 ms monophasic truncated exponential shock waveform compared with the 10 ms biphasic waveform. RESULTS: For both biphasic and monophasic waveforms, shock success rate (termination of @entity1 ) rose steadily as energy was increased. In the first study in the ' @entity0 ' 3-6 kg group, the 10 ms biphasic waveforms were superior to 5 ms monophasic waveforms at 10, 20, and 30 J energies, and in the ' @entity0 ' 7-12 kg group at 20 and 30 J energies (P<0.05). High success rates (>80%) were achieved by 20 J (4 J/kg) biphasic waveform shocks in the ' @entity0 ' piglets and 30 J (3 J/kg) biphasic waveform shocks in the ' @entity0 ' piglets. In the second study using a 10 ms monophasic waveform, we found similar results. Pulseless electrical activity occurred in two animals following biphasic shocks and in two animals following monophasic shocks. CONCLUSIONS: Biphasic waveforms proved superior to monophasic waveforms in both @entity0 and @entity0 models. High success rates were achieved with low-energy biphasic shocks. Biphasic waveform defibrillation is a promising advance in pediatric resuscitation.

title: XXXX : biphasic versus monophasic waveforms in an experimental model.

answer: @entity2


abstract: CONTEXT: Bone marrow/stem cell transplantation is becoming an increasingly common treatment for a variety of @entity4 . The treatment process is not benign. Both physiologic and psychological regimen-related side effects are common, @entity2 , and even life threatening. Music therapy is the prescribed use of music to aid in the prevention or amelioration of physical, @entity1 . Relaxation imagery, as used in this study, consisted of simple visualization and direct imagery-based suggestions. The mechanism of action of the intervention is hypothesized to be reduction of the stress response through neuroendocrine pathways. OBJECTIVE: To determine the feasibility of providing a combined music therapy and relaxation imagery intervention to @entity0 on a bone marrow transplant (BMT) unit and to examine the effects on the frequency and intensity of @entity2 and @entity3 , the two most common side effects associated with transplantation. DESIGN: Case controlled study. SETTING: University hospital-based bone marrow transplant unit serving @entity0 of all ages. @entity0 : Transplant recipients aged 4 years or older. INTERVENTION: 45-minute music-assisted relaxation and relaxation imagery sessions provided twice a week by a trained music therapist from date of enrollment into the study to discharge. MAIN OUTCOME MEASURES: Pre/post music/relaxation imagery intervention measures of @entity2 and @entity3 using a visual analog scale; determination of time-to-engraftment.

title: The effect of using music therapy with relaxation imagery in the management of XXXX undergoing bone marrow transplantation: a pilot feasibility study.

answer: @entity0


abstract: BACKGROUND: The mitotic kinase-encoding gene @entity6 / @entity6 / @entity6 is associated with @entity8 and transformation when overexpressed in @entity0 cells. @entity6 overexpression activates an unknown oncogenic pathway that involves centrosome amplification and results in missegregation of chromosomes. Because clinical prognosis and @entity2 @entity8 are tightly linked in @entity0 @entity4 , we examined whether increased @entity6 copy number and protein levels are linked to @entity8 in @entity4 . METHODS: @entity6 protein was visualized by immunohistochemistry in 205 @entity5 -fixed, @entity7 -embedded @entity0 @entity4 . @entity6 gene copy number was evaluated in 61 @entity2 by Southern blot hybridization and in 21 of these 61 @entity2 by fluorescence in situ hybridization (FISH). Copy numbers of chromosomes 3, 17, 20, and 21 were evaluated by FISH with chromosome-specific probes. @entity6 expression levels were related to histologic grade, stage, and DNA ploidy of the @entity2 and to the @entity0 ' follow-up data. The chi-square test for association was used to analyze the relationship between @entity6 expression and pathologic features. All statistical tests were two-sided. RESULTS: @entity2 with low levels of @entity6 amplification (3-4 copies) showed minimal deviation in their chromosome copy number and diploid or near-diploid total nuclear DNA content. @entity2 with higher levels of @entity6 amplification (>4 copies) had a major increase of chromosome copy number and of their total nuclear DNA content, i.e., exhibited pronounced @entity8 . Elevated expression of @entity6 was strongly associated with parameters of clinical @entity3 including high histologic grade (P<.001), invasion (P<.001), increased rate of @entity1 (P<.001), and decreased @entity1 -free (P<.001) and overall (P<.001) survival of @entity0 with @entity4 . CONCLUSION: @entity6 gene amplification and associated increased expression of the mitotic kinase it encodes are associated with @entity8 and @entity3 clinical behavior in @entity0 @entity4 .

title: Amplification/overexpression of a mitotic kinase gene in @entity0 XXXX .

answer: @entity4


abstract: BACKGROUND: The mitotic kinase-encoding gene @entity6 / @entity6 / @entity6 is associated with @entity8 and transformation when overexpressed in @entity0 cells. @entity6 overexpression activates an unknown oncogenic pathway that involves centrosome amplification and results in missegregation of chromosomes. Because clinical prognosis and @entity2 @entity8 are tightly linked in @entity0 @entity4 , we examined whether increased @entity6 copy number and protein levels are linked to @entity8 in @entity4 . METHODS: @entity6 protein was visualized by immunohistochemistry in 205 @entity5 -fixed, @entity7 -embedded @entity0 @entity4 . @entity6 gene copy number was evaluated in 61 @entity2 by Southern blot hybridization and in 21 of these 61 @entity2 by fluorescence in situ hybridization (FISH). Copy numbers of chromosomes 3, 17, 20, and 21 were evaluated by FISH with chromosome-specific probes. @entity6 expression levels were related to histologic grade, stage, and DNA ploidy of the @entity2 and to the @entity0 ' follow-up data. The chi-square test for association was used to analyze the relationship between @entity6 expression and pathologic features. All statistical tests were two-sided. RESULTS: @entity2 with low levels of @entity6 amplification (3-4 copies) showed minimal deviation in their chromosome copy number and diploid or near-diploid total nuclear DNA content. @entity2 with higher levels of @entity6 amplification (>4 copies) had a major increase of chromosome copy number and of their total nuclear DNA content, i.e., exhibited pronounced @entity8 . Elevated expression of @entity6 was strongly associated with parameters of clinical @entity3 including high histologic grade (P<.001), invasion (P<.001), increased rate of @entity1 (P<.001), and decreased @entity1 -free (P<.001) and overall (P<.001) survival of @entity0 with @entity4 . CONCLUSION: @entity6 gene amplification and associated increased expression of the mitotic kinase it encodes are associated with @entity8 and @entity3 clinical behavior in @entity0 @entity4 .

title: Amplification/overexpression of a mitotic kinase gene in XXXX @entity4 .

answer: @entity0


abstract: OBJECTIVE: To study the clinical value of conservative surgery for @entity5 in reducing symptoms and raising pregnancy rate. METHODS: 26 @entity0 with histologically proven @entity5 who wanted to preserve their reproductive capacity had conservative surgery (adenomyomectomy or remove @entity1 ). The @entity0 's average age was 35.8 years. The main complaints were @entity4 and @entity3 . Of the 22 married @entity0 , 7 had primary @entity2 (31.8%), 10 had secondary @entity2 (45.5%) and 3 had @entity7 (13.6%). RESULTS: 10 @entity0 had @entity6 , the lesion were completely removed. Sixteen @entity0 had @entity5 , the part of lesion were removed. The rate of the severe @entity4 and @entity3 after operation were significantly lower than that before (P < 0.001). After operation, 7 @entity0 with @entity6 wanted to have a baby, 5 @entity0 conceived, of the total 9 pregnancies, 5 ended in term pregnancy; 14 @entity0 with diffuse @entity5 wanted to have a baby, 3 @entity0 had 3 pregnancies. One of which ended in term pregnancy. The rate of pregnancy and term delivery in @entity6 @entity0 were significantly higher than that of @entity5 @entity0 (P = 0.03, P = 0.002). Among 26 @entity0 , 3 relapsed. The average relapse time was 49.6 months. CONCLUSIONS: The conservative surgery for @entity6 can reduce symptom and raise pregnancy rate significantly, it can be accepted by young @entity0 who want to preserve their reproductive capacity. Though the pregnancy rate of conservative surgery for diffused @entity5 was low, it still has therapeutic value.

title: [Clinical observation of conservative surgery for XXXX ].

answer: @entity5


abstract: The ability of @entity1 cells to metastasize hematogenously is regulated by their interactions with polymorphonuclear leukocytes (PMNs). However, the mechanisms mediating PMN binding to @entity1 cells under physiological shear forces remain largely unknown. This study was designed to characterize the molecular interactions between PMNs and @entity1 cells as a function of the dynamic shear environment, using two @entity0 @entity3 cell lines (LS174T and HCT-8) as models. PMN and @entity3 cell suspensions, labeled with distinct fluorophores, were sheared in a cone-and-plate rheometer in the presence of the PMN activator @entity6 . The size distribution and cellular composition of formed aggregates were determined by flow cytometry. PMN binding to LS174T cells was maximal at 100 s(-1) and decreased with increasing shear. At low shear (100 s(-1)) PMN @entity7 alone mediates PMN-LS174T heteroaggregation. However, @entity4 , @entity5 , and @entity7 are all required for PMN binding to sialyl Lewis(x)-bearing LS174T cells at high shear (800 s(-1)). In contrast, sialyl Lewis(x)-low HCT-8 cells fail to aggregate with PMNs at high shear conditions, despite extensive adhesive interactions at low shear. Taken together, our data suggest that PMN @entity4 initiates LS174T cell tethering at high shear by binding to sialylated moieties on the @entity2 cell surface, whereas the subsequent involvement of @entity5 and @entity7 converts these transient tethers into stable adhesion. This study demonstrates that the shear environment of the vasculature modulates the dynamics and molecular constituents mediating PMN- @entity1 cell adhesion.

title: Hydrodynamic shear regulates the kinetics and receptor specificity of polymorphonuclear leukocyte- XXXX cell adhesive interactions.

answer: @entity3


abstract: The localization and functions of @entity3 receptors (KARs) in the CNS are still poorly known. In the striatum, @entity2 /7 and @entity5 immunoreactivity is expressed presynaptically in a subpopulation of glutamatergic terminals and postsynaptically in dendrites and spines. The goal of this study was to further characterize the subcellular and subsynaptic localization of @entity3 receptor subunits in the monkey striatum. Immunoperoxidase data reveal that the relative abundance of @entity2 /7- and @entity5 -immunoreactive terminals is homogeneous throughout the striatum irrespective of the differential degree of @entity4 in @entity0 . Pre-embedding and post-embedding immunogold data indicate that >70% of the presynaptic or postsynaptic @entity2 /7 and @entity5 labeling is expressed intracellularly. In material stained with the post-embedding immunogold method, approximately one-third of plasma membrane-bound gold particles labeling in axon terminals and spines is associated with asymmetric synapses, thereby representing synaptic @entity3 receptor subunits. On the other hand, >60% of the plasma-membrane bound labeling is extrasynaptic. Both @entity2 /7 and @entity5 labeling in glutamatergic terminals often occurs in clusters of gold particles along the membrane of large vesicular organelles located at various distances from the presynaptic grid. Anterograde labeling from the primary motor cortex or the centromedian thalamic nucleus indicate that both corticostriatal and thalamostriatal terminals express presynaptic @entity2 /7 and @entity5 immunoreactivity in the postcommissural putamen. In conclusion, these data demonstrate that @entity3 receptors in the striatum display a pattern of subcellular distribution different from other ionotropic @entity1 receptor subtypes, but consistent with their metabotropic-like functions recently shown in the hippocampus.

title: Subcellular and subsynaptic localization of presynaptic and postsynaptic XXXX receptor subunits in the monkey striatum.

answer: @entity3


abstract: BACKGROUND: House dust mite (HDM) allergen might induce and maintain @entity3 ( @entity3 ). Reduction of allergen load by applying encasings might improve the clinical symptoms of @entity3 . OBJECTIVE: We sought to investigate, in a randomized, double-blind, placebo-controlled study, whether reducing HDM allergen levels by using mattress, duvet, and pillow encasings for 12 months will result in improvement in @entity3 symptoms. METHODS: @entity0 with @entity3 (8-50 years old and @entity2 ), having a Leicester sign score (a @entity4 score) of at least 1% extent and a severity score of 6 points or greater, were randomly allocated to an active (n = 45) or a placebo allergen-avoidance group (n = 41). Avoidance measures consisted of applying HDM-impermeable encasings for mattresses, pillows, and duvets for the active treatment group and @entity5 encasings for the placebo group. Effect on allergen concentrations (Der @entity6 and Der @entity6 plus Der f 1), Leicester sign score extent and severity, visual analogue scale scores for itching and @entity1 , intradermal test results, atopy patch test results, total serum IgE levels, anti-Der @entity6 -specific IgE levels, and total blood eosinophil counts were studied. RESULTS: The active encasings reduced the Der @entity6 allergen concentration in the mattress after 12 months with a factor 2.1 (P =.007) and the Der @entity6 plus Der f 1 allergen concentration with a factor of 2.5 (P =.005); no significant change in allergen concentrations in mattresses was seen in the placebo group. Although the decrease in allergen load was significant, no differences in treatment-induced changes were seen between the placebo and active groups. CONCLUSIONS: Use of HDM-impermeable encasings resulted in a significant decrease in Der @entity6 and Der @entity6 plus Der f 1 allergen concentrations. However, this reduction in allergen load did not result in significant changes in clinical parameters between the groups. Reduction of allergens in other environments (work, school, and outdoors) might be equally important in improving symptoms of @entity3 .

title: Effect of mattress encasings on XXXX outcome measures in a double-blind, placebo-controlled study: the Dutch mite avoidance study.

answer: @entity3


abstract: PURPOSE: We compared hypoautofluorescent (hypoAF) areas detected with near-infrared (NIR-AF) and short-wavelength autofluorescence (SW-AF) in @entity0 with @entity1 ( @entity2 ) to retinal structure using spectral domain optical coherence tomography (SD-OCT). METHODS: The SD-OCT volume scans, and SW-AF and NIR-AF images were obtained from 15 eyes of 15 @entity0 with @entity2 and registered to each other. Thickness maps of the total retina, receptor-plus layer (R+, from distal border of the RPE to outer plexiform/inner nuclear layer boundary), and outer segment-plus layer (OS+, from distal border of the RPE to ellipsoid zone [EZ] band) were created from SD-OCT scans. These were compared qualitatively and quantitatively to the hypoAF areas in SW-AF and NIR-AF images. RESULTS: All eyes showed a hypoAF area in the central macula and loss of the EZ band in SD-OCT scans. The hypoAF area was larger in NIR than SW-AF images and it exceeded the area of EZ band loss for 12 eyes. The thickness maps showed progressive thinning towards the central macula, with the OS+ layer showing the most extensive and severe thinning. The central hypoAF areas on NIR corresponded to the OS+ thinned areas, while the hypoAF areas on SW-AF corresponded to the R+ thinned areas. CONCLUSIONS: Since the larger hypoAF area on NIR-AF exceeded the region of EZ band loss, and corresponded to the OS+ thinned area, RPE cell loss occurred before photoreceptor cell loss. The NIR-AF imaging may be an effective tool for following progression and predicting loss of photoreceptors in @entity2 .

title: Near-infrared autofluorescence: its relationship to short-wavelength autofluorescence and optical coherence tomography in XXXX .

answer: @entity1


abstract: BACKGROUND: The relationship between @entity7 and @entity1 has long been known. Only a single study in the United States, from Buffalo, New York, has reported the prevalence of @entity7 in a pediatric @entity1 population. This study was conducted to determine the prevalence and clinical presentation of @entity7 in @entity0 and adolescents with @entity1 in Wisconsin, USA, using serum antiendomysial antibody as a screening test. METHODS: Two hundred eighteen @entity0 with @entity1 (113 males; age range, 4-21 years) and 117 age-and gender-matched control @entity0 were tested for immunoglobulin A endomysial antibody. Patients with positive results were offered a small bowel biopsy. A questionnaire regarding @entity4 , @entity3 , and @entity5 was completed by the parents. RESULTS: Seventeen of 218 @entity1 @entity0 (7.7%) had positive endomysial antibody. All control @entity0 had negative results for the endomysial antibody. Small bowel biopsy was performed in 14 @entity0 . Ten @entity0 had @entity2 . In one @entity0 without @entity2 , a repeat biopsy 2 years later showed @entity2 , and two @entity0 had increased intraepithelial lymphocytes without @entity2 . Seventy percent of the @entity0 with @entity7 were asymptomatic. The reported symptoms were @entity4 and @entity3 (n = 1) and @entity5 (n = 2). Two @entity0 with @entity7 had @entity6 . CONCLUSIONS: The prevalence of @entity7 in @entity0 with @entity1 in Wisconsin is at least 4.6%, which is comparable with European and Canadian studies. Because @entity0 without @entity2 may have @entity7 , the prevalence may be even higher. All @entity0 with @entity1 should be screened for @entity7 .

title: The prevalence and clinical characteristics of XXXX in @entity1 in Wisconsin.

answer: @entity7


abstract: BACKGROUND: The relationship between @entity7 and @entity1 has long been known. Only a single study in the United States, from Buffalo, New York, has reported the prevalence of @entity7 in a pediatric @entity1 population. This study was conducted to determine the prevalence and clinical presentation of @entity7 in @entity0 and adolescents with @entity1 in Wisconsin, USA, using serum antiendomysial antibody as a screening test. METHODS: Two hundred eighteen @entity0 with @entity1 (113 males; age range, 4-21 years) and 117 age-and gender-matched control @entity0 were tested for immunoglobulin A endomysial antibody. Patients with positive results were offered a small bowel biopsy. A questionnaire regarding @entity4 , @entity3 , and @entity5 was completed by the parents. RESULTS: Seventeen of 218 @entity1 @entity0 (7.7%) had positive endomysial antibody. All control @entity0 had negative results for the endomysial antibody. Small bowel biopsy was performed in 14 @entity0 . Ten @entity0 had @entity2 . In one @entity0 without @entity2 , a repeat biopsy 2 years later showed @entity2 , and two @entity0 had increased intraepithelial lymphocytes without @entity2 . Seventy percent of the @entity0 with @entity7 were asymptomatic. The reported symptoms were @entity4 and @entity3 (n = 1) and @entity5 (n = 2). Two @entity0 with @entity7 had @entity6 . CONCLUSIONS: The prevalence of @entity7 in @entity0 with @entity1 in Wisconsin is at least 4.6%, which is comparable with European and Canadian studies. Because @entity0 without @entity2 may have @entity7 , the prevalence may be even higher. All @entity0 with @entity1 should be screened for @entity7 .

title: The prevalence and clinical characteristics of @entity7 in XXXX in Wisconsin.

answer: @entity1


abstract: OBJECTIVE: To report the occurrence of life-threatening hyperkalaemia following treatment with therapeutic @entity6 @entity3 . SETTING: The neurosurgical intensive care units of Royal North Shore Hospital and Liverpool Hospital, Sydney, Australia. @entity0 : Three @entity0 treated with theraputic @entity6 @entity3 . One @entity0 with raised intracranial pressure secondary to a severe @entity1 and two @entity0 with refractory @entity5 secondary to @entity2 . Two of the three @entity0 developed hypokalaemia on starting @entity6 , which was resistant to @entity4 supplementation. All three @entity0 developed severe hyperkalaemia during the recovery phase of @entity3 . This was life-threatening in all three @entity0 and fatal in one. CONCLUSIONS: Severe hypokalaemia refractory to @entity4 therapy may occur during therapeutic @entity6 @entity3 . Severe rebound hyperkalaemia may occur after cessation of @entity6 infusion. Protocols for the management of @entity0 with therapeutic barbiturate @entity3 should recognise this potentially serious complication.

title: Life-threatening hyperkalaemia following therapeutic barbiturate XXXX .

answer: @entity3


abstract: The aim of this study is to analyze the impact of the @entity4 severity on graft size requirements and outcome in adult-to-adult living donor liver transplantation. A limiting factor in adult-to-adult living donor liver transplantation has been adequacy of graft size. A minimal graft-recipient weight ratio (GRWR) of 0.8% to 1% has been suggested, without taking the @entity4 into account. Forty adults underwent liver transplantation using left (n = 10; mean weight, 481 +/- 83 g) or right lobes (n = 30; mean weight, 845 +/- 182 g). We recorded graft survival, @entity0 -Turcotte-Pugh score, and occurrence of small-for-size syndrome (poor bile production, prolonged postoperative prothrombin time, and @entity5 without @entity2 markers). Small grafts were defined as GRWR of < or =0.85%. Large grafts were defined as GRWR greater than 0.85%. Six @entity0 died within 6 months of transplantation (early @entity0 survival rate, 85%); two @entity0 died late of @entity1 recurrence. Among transplant recipients with normal liver function or @entity0 's class A, there was no significant difference with the use of small (n = 6) or large (n = 9) grafts (graft survival rates, 83% v 88%, respectively; P =.65). Among @entity0 with @entity0 's class B or C, graft survival rates were 74% in recipients of large grafts (n = 19) and 33% in recipients of small grafts (n = 6; P =.023). Five of 6 @entity0 with @entity0 's class B or C who received small grafts developed small-for-size syndrome; 2 @entity0 died (1 @entity0 after retransplantation) and 3 @entity0 survived (2 @entity0 after retransplantation). Graft function and survival are influenced not only by graft size, but also by pretransplantation disease severity. GRWR as low as 0.6% can be used safely in @entity0 without @entity3 or in @entity0 with @entity0 's class A. Transplant recipients with @entity0 's class B or C require a GRWR greater than 0.85% to avoid small-for-size syndrome and related complications.

title: Critical graft size in adult-to-adult living donor liver transplantation: impact of the XXXX .

answer: @entity4


abstract: In vivo protein synthesis decreases in mononuclear cells following a combined stress hormone infusion given to healthy volunteers as a @entity0 @entity1 model. Here, the purpose was to further investigate this finding and to measure in vivo protein synthesis in isolated T lymphocytes. Furthermore, the effects of stress hormones on the lymphocyte subpopulations and mononuclear cells, characterized by flow cytometry and phytohemagglutinin (PHA)-induced and unstimulated proliferative responses in vitro, were elucidated. Healthy volunteers (n = 16) were randomized into 2 groups to receive either a stress hormone or a saline infusion for 6 hours. In vivo protein synthesis was studied before and after the treatment by measuring the incorporation of stable isotopically-labeled @entity4 into lymphocyte and mononuclear cell proteins. Protein synthesis decreased after stress hormone infusion in both cell populations: in T lymphocytes from 13.0% +/- 0.7%/d (mean +/- SD) to 8.6% +/- 2.1%/d (P <.01) and in mononuclear cells from 13.3% +/- 1.2%/d to 6.3 +/- 2.0%/d (P <.001). No change in proliferative responsiveness in vitro was observed. The stress hormone infusion produced a decrease in the percentage of T helper CD3/ @entity2 from 41% to 18% (P <.001), T cytotoxic CD3/ @entity3 from 27% to 15% (P <.001), as well as total T CD3 cells from 69% to 35% (P <.001). There was an increase in the percentage of natural killer (NK) cells @entity7 / @entity6 from 17% to 55% (P <.001). Determination of phenotypes expressed on activated T lymphocytes showed that CD3/HLA-DR was unchanged and CD3/ @entity5 decreased from 14% to 7% (P <.01) in the stress hormone group. The study showed that the decrease of in vivo protein synthesis was 34% in T lymphocytes as compared with 53% in mononuclear cells, when determined immediately after a 6-hour stress hormone infusion. This change was associated with a pronounced decrease in all lymphocyte subpopulations, except for the NK cells, which increased substantially.

title: A combined stress hormone infusion decreases in vivo protein synthesis in XXXX T lymphocytes in healthy volunteers.

answer: @entity0


abstract: A recent study reported on an anti- @entity4 /anti-CD3 single-chain bispecific antibody (bscCD19xCD3) exhibiting high activity against @entity0 @entity6 cell lines (L  ffler et al., Blood 2000;95:2098-103). In the present study, we have explored in detail the in vitro efficacy, T-cell donor variability, binding characteristics, specificity, kinetics and @entity5 ( @entity5 ) dependence of bscCD19xCD3. We found that a majority of @entity0 donor T cells tested (n = 86) gave half-maximal B- @entity3 cell lysis (ED(50)) within a range of 10-50 pg/ml bscCD19xCD3, corresponding to sub-picomolar concentrations of the bispecific antibody. Under identical experimental conditions, the anti- @entity7 monoclonal antibody rituximab had an at least 100,000-fold lower in vitro efficacy. The extreme potency of bscCD19xCD3 was in sharp contrast to the relatively low affinity of the anti-CD3 and anti- @entity4 single-chain Fv portions in K(D) ranges of 10(-7) and 10(-9) M, respectively. Cell lysis by bscCD19xCD3 was predominantly mediated by the population of @entity2 /CD45RO-positive T cells. Both immortalized @entity1 - and @entity2 -positive @entity0 T-cell clones were highly active effector cells as well. Cell lysis by bscCD19xCD3 was rapid and specific. The respective parental monoclonal antibodies inhibited cell lysis and @entity4 -negative cells were not harmed by T cells in the presence of high amounts of bscCD19xCD3. The potent T-cell stimulus @entity5 could not markedly augment the activity of bscCD19xCD3-stimulated T cells. In conclusion, bscCD19xCD3 could redirect unstimulated cytotoxic T cells against @entity4 -positive cells in an unexpectedly potent, rapid and specific fashion.

title: Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against XXXX cells catalyzed by a single-chain bispecific antibody.

answer: @entity3


abstract: BACKGROUND: The prognosis of @entity0 with @entity3 ( @entity3 ) with @entity4 ( @entity4 ) is extremely poor. The aim of this study was to elucidate the efficacy of @entity2 ( @entity2 ) for @entity0 with advanced HCCs. METHODS: Forty-eight @entity3 @entity0 with @entity4 were treated by @entity2 via a subcutaneously implanted injection port. Of these, 14 had @entity4 in the second portal branch and 34 @entity0 had @entity4 in the first portal branch or in the main portal trunk. One course of chemotherapy consisted of daily @entity5 (7 mg/m(2) for 1 hour on Days 1-5) followed by @entity6 (170 mg/m(2) for 5 hours on Days 1-5). @entity0 were scheduled to receive four serial courses of @entity2 . Responders were defined as having either a complete response (CR) or partial response (PR) and nonresponders were defined as exhibiting stable disease or @entity1 . The prognosis after @entity2 and factors related to survival were analyzed. RESULTS: Following @entity2 , 4 and 19 @entity0 exhibited a CR and PR, respectively (response rate = 48%). The 1, 2, 3, and 5-year cumulative survival rates of 48 @entity0 treated with @entity2 were 45%, 31%, 25%, and 11%, respectively. Median survival periods for 23 responders and 25 nonresponders were 31.6 (range, 8.3-76.9) months and 5.4 (1.9-29.0) months, respectively. Therapeutic effect (P < 0.001) and hepatic reserve capacity (P = 0.021) were identified as significant prognostic factors by univariate analysis. Multivariate analysis identified only therapeutic effect as being significantly related to survival. CONCLUSIONS: @entity2 using low-dose @entity5 and @entity6 may be a useful therapeutic option for @entity0 with advanced @entity3 with @entity4 . @entity3 @entity0 with @entity4 who respond to @entity2 could certainly have survival benefits.

title: Hepatic arterial infusion chemotherapy for advanced XXXX with @entity4 : analysis of 48 cases.

answer: @entity3