abstract: BACKGROUND AND PURPOSE: Language barriers may lead to poor quality of care, particularly for conditions like @entity3 for which diagnosis and treatment decision making rely on taking an accurate @entity0 history. The purpose of this study was to determine the impact of @entity0 language barriers on quality of @entity3 care and clinical outcomes. METHODS: This retrospective cohort study used data from the Registry of the Canadian @entity3 Network. All Ontario @entity0 who were admitted with @entity3 or transient @entity2 attack between July 2003 and March 2008 were selected. Mortality, @entity3 outcomes, in-hospital complications, quality of care, and disposition were compared between those without (n=12 787) and with (n=1506) language barriers, which was defined based on the @entity0 's preferred language. Hierarchical multivariable regression models determined the effect of language barriers, independent of baseline covariates. RESULTS: @entity0 with language barriers had better 7-day mortality than those without (7.0% versus 9.2%; OR, 0.69; 95% CI, 0.57-0.82; P<0.001). However, they were more likely to be discharged with a moderate-to-severe @entity1 (65.9% versus 51.5%; OR, 1.25; 95% CI, 1.15-1.35). In-hospital complication rates did not differ, and quality of care indicators generally favored @entity0 with language barriers. CONCLUSIONS: @entity0 who had language barriers had reduced mortality and better performance on some quality of care measures. These differences existed despite adjustment for many potential confounders, including ethnicity, prognostic factors, and @entity3 characteristics.

title: Impact of Language Barriers on XXXX Care and Outcomes.

answer: @entity3


abstract: BACKGROUND: In the largest @entity2 ( @entity2 ) outbreak in history, nosocomial transmission of  @entity2 increased spread of the disease. We report on 2 instances in Sierra Leone where @entity0 unknowingly infected with @entity2 were admitted to a general hospital ward (1 pediatric ward and 1 maternity ward), exposing health care workers, caregivers, and other @entity0 to @entity2 . Both @entity0 died on the general wards, and were later confirmed as being infected with @entity2 . We initiated contact tracing and assessed risk factors for @entity1 to guide containment recommendations. METHODS: We reviewed medical records to establish the index @entity0 ' symptom onset. Health care workers, @entity0 , and caregivers were interviewed to determine exposures and personal protective equipment (PPE) use. Contacts were monitored daily for @entity2 symptoms. Those who experienced @entity2 symptoms were isolated and tested. RESULTS: Eighty-two contacts were identified: 64 health care workers, 7 caregivers, 4 @entity0 , 4 newborns, and 3 @entity0 of @entity0 . Seven contacts became symptomatic and tested positive for @entity2 : 2  health care workers (1 nurse and 1 hospital cleaner), 2 caregivers, 2 newborns, and 1 @entity0 . The infected nurse placed an intravenous catheter in the pediatric index @entity0 with only short gloves PPE and the hospital cleaner cleaned the operating room of the maternity ward index @entity0 wearing short gloves PPE. The maternity ward index @entity0 's caregiver and newborn were exposed to her body fluids. The infected @entity0 and her newborn shared the ward and latrine with the maternity ward index @entity0 . Hospital staff members did not use adequate PPE. Caregivers were not offered PPE. CONCLUSIONS: Delayed recognition of @entity2 and inadequate PPE likely led to exposures and @entity1 . Earlier recognition of @entity2 and adequate PPE might have reduced direct contact with body fluids. Limiting nonhealth-care worker contact, improving access to PPE, and enhancing screening methods for pregnant @entity0 , @entity0 , and inpatients may help decrease @entity2 transmission in general health care settings.

title: Nosocomial transmission of XXXX on pediatric and  maternity wards: Bombali and Tonkolili, Sierra Leone, 2014.

answer: @entity2


abstract: BACKGROUND: @entity9 are common in @entity3 ( @entity3 ) and respond poorly to medication. This study aimed to analyze the risk factors for @entity9 in @entity3 . METHODS: Ninety-one @entity0 with @entity3 (aged 34-83 years old) were recruited. @entity0 were assessed with the Unified @entity3 Rating Scale (UPDRS), Hoehn and Yahr stage, Pittsburgh Sleep Quality Index (PSQI), @entity4 (HAMD), and @entity2 ( @entity2 ). Micturition number was recorded, and Type B ultrasound was used to evaluate residual urine. Statistics was performed using binary logistic regression, bivariate correlations, and Chi-square and t-tests. RESULTS: Of 91 @entity0 , @entity5 occurred in 55.0%. Among these, 49.5% suffered with @entity6 , 47.3% with pollakiuria. @entity6 number had a positive linear relationship with @entity2 score (odds ratio [OR] = 0.340, P = 0.001), HAMD score (OR = 0.323, P = 0.002), duration of @entity7 medication (OR = 0.328, P = 0.001), dose of @entity7 (OR = 0.273, P = 0.009), UPDRS-II (OR = 0.402, P = 0.000), UPDRS-III score (OR = 0.291, P = 0.005), and PSQI score (OR = 0.249, P = 0.017). Micturition number over 24 h was positively associated with @entity2 (OR = 0.303, P = 0.004) and UPDRS-II scores (OR = 0.306, P = 0.003). Of @entity0 with residual urine, 79.3% had a volume of residual urine <50 ml. Residual urine was present in 44.4% of the @entity0 with @entity6 , 46.5% of the @entity0 with pollakiuria, and 80.0% of the @entity0 with @entity8 . More @entity0 than @entity0 had residual urine (35.2% male vs. 13.3% female; P = 0.002). CONCLUSIONS: @entity6 and pollakiuria were common micturition symptoms in our @entity0 with @entity3 . @entity6 was associated with @entity4 , @entity2 , @entity1 , and severity of @entity3 . Pollakiuria was associated with @entity2 and severity of @entity3 . Male @entity0 were more prone to residual urine and pollakiuria.

title: Investigation of XXXX in @entity3 .

answer: @entity9


abstract: BACKGROUND: @entity9 are common in @entity3 ( @entity3 ) and respond poorly to medication. This study aimed to analyze the risk factors for @entity9 in @entity3 . METHODS: Ninety-one @entity0 with @entity3 (aged 34-83 years old) were recruited. @entity0 were assessed with the Unified @entity3 Rating Scale (UPDRS), Hoehn and Yahr stage, Pittsburgh Sleep Quality Index (PSQI), @entity4 (HAMD), and @entity2 ( @entity2 ). Micturition number was recorded, and Type B ultrasound was used to evaluate residual urine. Statistics was performed using binary logistic regression, bivariate correlations, and Chi-square and t-tests. RESULTS: Of 91 @entity0 , @entity5 occurred in 55.0%. Among these, 49.5% suffered with @entity6 , 47.3% with pollakiuria. @entity6 number had a positive linear relationship with @entity2 score (odds ratio [OR] = 0.340, P = 0.001), HAMD score (OR = 0.323, P = 0.002), duration of @entity7 medication (OR = 0.328, P = 0.001), dose of @entity7 (OR = 0.273, P = 0.009), UPDRS-II (OR = 0.402, P = 0.000), UPDRS-III score (OR = 0.291, P = 0.005), and PSQI score (OR = 0.249, P = 0.017). Micturition number over 24 h was positively associated with @entity2 (OR = 0.303, P = 0.004) and UPDRS-II scores (OR = 0.306, P = 0.003). Of @entity0 with residual urine, 79.3% had a volume of residual urine <50 ml. Residual urine was present in 44.4% of the @entity0 with @entity6 , 46.5% of the @entity0 with pollakiuria, and 80.0% of the @entity0 with @entity8 . More @entity0 than @entity0 had residual urine (35.2% male vs. 13.3% female; P = 0.002). CONCLUSIONS: @entity6 and pollakiuria were common micturition symptoms in our @entity0 with @entity3 . @entity6 was associated with @entity4 , @entity2 , @entity1 , and severity of @entity3 . Pollakiuria was associated with @entity2 and severity of @entity3 . Male @entity0 were more prone to residual urine and pollakiuria.

title: Investigation of @entity9 in XXXX .

answer: @entity3


abstract: PURPOSE: To evaluate the influence of the needle size used for intravitreal (IVT) injections on @entity0 ' @entity1 experience in a randomized, double-armed, single-blinded, clinical trial. METHODS: @entity0 included were randomized to have an IVT injection performed with a 27-gauge needle (group 1) or with a 30-gauge needle (group 2). The topical anaesthesia before the injection was standardized. Immediately after the injection, @entity0 were asked to grade their @entity1 using the visual analogue scale (VAS) and the Wong-Baker FACES scale. The main outcome measure was the @entity1 score assessment. Cofactors analysed were @entity0 ' demographics (age and gender) and clinical characteristics (such as the number of previous IVT injections). In addition, scaled surgeon's questionnaires to assess the IVT injection procedure were evaluated. For statistical analysis, a regression model was used. RESULTS: The data of 208 @entity0 (group 1: 104 @entity0 ; group 2: 104 @entity0 ) were analysed. There was no significant difference in the VAS @entity1 scores (p  >  0.18) and in the Wong-Baker @entity1 scores (p  >  0.59) between both treatment groups. Gender (p  =  0.0288) and the number of previous IVT injections (p  =  0.0028) significantly influenced the VAS @entity1 scores (p  <  0.05). Female @entity0 and @entity0 with a history of previous IVT injections had higher @entity1 scores. The surgeon's questionnaire showed an overall preference towards the use of a 30-gauge needle for IVT injections. CONCLUSION: The use of a 30-gauge needle for IVT injections showed no significant effect in @entity1 relief compared to the use of a 27-gauge needle. However, a 30-gauge needle was preferred by all surgeons.

title: Needle size in intravitreal injections - XXXX evaluation of a randomized clinical trial.

answer: @entity1


abstract: The linear no-threshold model (LNT) was recommended in 1956, with abandonment of the traditional threshold dose-response for genetic risk assessment. Adoption of LNT by the International Commission on Radiological Protection (ICRP) became the standard for radiation regulation worldwide. The ICRP recommends a dose limit of 1 mSv/ @entity4 r for the public, which is too low and which terrorizes innocent peop @entity0 deed, LNT arose mainly from the lifespan survivor study (LSS) of atomic bomb survivors. The LSS, which asserts linear dose-response and no threshold, is challenged mainly on three points. 1) Radiation doses were underestimated by half because of disregard for major residual radiation, resulting in canc @entity1 k overestimation. 2) The dose and dose-rate effectiveness factor (DDREF) of 2 is used, but the actual DDREF is estimated as 16, resulting in canc @entity1 k overestimation by several times. 3) Adaptive response (hormesis) is observed in leuk @entity3 solid canc @entity1 es, consistently contradicting the linearity of LNT. Dras @entity1 k moves the dose-response curve close to the control line, allowing the setting of a threshold. Living organisms have been evolving for 3.8 billion years under radiation exposure, naturally acquiring various defense mechanisms such as DNA repair mechanisms, apoptosis, and immune response. The failure of LNT lies in the neglect of carc @entity2 these biological mechanisms. Obstinate application of LNT continues to cause tremendous huma @entity0 cial, and economic losses. The 60-year-old LNT must be rejected to establish a new scientific knowledge-based system.

title: Tremendous XXXX , Social, and Economic Losses Caused by Obstinate Application of the Failed Linear No-threshold Model.

answer: @entity0


abstract: CONTEXT: There are limited studies on comparison of Total etch (TE) and @entity3 ( @entity2 ) adhesive for placement of sealants. AIMS: The aim of the study was to compare the retention of fissure sealants placed using TE adhesive to those sealants placed using @entity2 ( @entity2 ) adhesive. SETTINGS AND DESIGN: The study was conducted in the dental section, Aga Khan University Hospital. This study was a randomized single blinded trial with a @entity1 design. MATERIALS AND METHODS: The study included 37 @entity0 , 101 teeth were included in both study groups. The intervention arm was treated with @entity2 Adhesive (Adper Easy One, 3M ESPE, US). Control arm received TE adhesive (Adper Single Bond 2, 3M ESPE, US) before sealant application. The @entity0 were followed after 6 months for assessment of sealant retention. STATISTICAL ANALYSIS USED: Interexaminer agreement for outcome assessment was assessed by Kappa Statistics and outcome in intervention group was assessed by McNemar's test. RESULTS: Ninety-one pairs of molar (90%) were reevaluated for sealant retention. Complete retention was 56% in TE arm and 28% in @entity2 arm with an odds ratio (OR) of 3.7. CONCLUSIONS: Sealants applied with TE adhesives show higher rate of complete sealant retention than @entity2 adhesive.

title: A randomized control clinical trial of fissure sealant retention: XXXX adhesive versus total etch adhesive.

answer: @entity3


abstract: INTRODUCTION: Photoselective vaporization of the prostate ( @entity2 ) has been widely adopted as a surgical treatment for lower urinary tract symptoms due to @entity1 ( @entity1 ). Recently, a high-powered 180 W @entity3 (LBO) laser has become commercially available and there is relatively little information on the impact of this very high-powered laser on perioperative outcomes. Even more so is the impact of the laser on outcomes according to prostate size. OBJECTIVES: The objective of this study was to evaluate perioperative outcomes after @entity2 with the 180W laser, relative to prostate size. @entity0 AND METHODS: A prospectively maintained institutional ethics approved database was retrospectively reviewed. Subjects were analyzed according to transrectal ultrasound and categorized into groups namely 0-39 mL, 40-79 mL, 80-120 mL and >120 mL. Perioperative measures included energy utilized, length of operation, duration catheterization, post operative length of stay (POLOS), Clavien-Dindo adverse events and number discharged home within 24 hours catheter free. RESULTS: With increasing prostate size, there was a statistically significant increase in energy utilization and operation time (P < 0.01 between groups). Duration of catheterization, POLOS, incidence of Grade 3 and above Clavien-Dindo adverse events and discharge home catheter free within 24 hours was not statistically significant across groups. CONCLUSIONS: Prostate volume impacts upon energy utilized with @entity2 surgery. Prostate volume does not influence duration of catheterization or POLOS. Clavien-Dindo Grade 3 or greater adverse events were low and do not appear to be influenced by prostate size. The ability to be discharged home catheter free within 24 hours likewise does not appear to be influenced by prostate size.

title: Does prostate size impact upon perioperative outcomes associated with photoselective vaporization of the prostate using the 180W XXXX laser?

answer: @entity3


abstract: OBJECTIVE: We reviewed our experience of surgery for @entity3 ( @entity3 ) with or without history of @entity5 . METHODS: Data were reviewed from 65 (33 male) @entity0 with @entity3 who underwent surgery between 1993 and 2014; palliative cases were excluded. RESULTS: Mean age at surgery was 5.1 (range 0.2-19) years, with mean postsurgical follow-up of 45.3 (6-120) months. Mean number of anticonvulsants used preoperatively was 4.2 (2-8), which decreased to 1.2 (0-4) postoperatively (p < 0.0001). Total hemispherectomy was the most commonly performed surgery (n = 20), followed by subtotal hemispherectomy (n = 17), multilobar resection (n = 13), lobectomy (n = 7), tuberectomy (n = 6), and lobectomy + tuberectomy (n = 2), with International League Against @entity3 (ILAE) class I outcome in 20, 10, 7, 6, 3, and 0 @entity0 , respectively (total 46/65 (71%); 22 off medication). Shorter duration of @entity3 (p = 0.022) and presence of magnetic resonance imaging (MRI) lesion (p = 0.026) were independently associated with class I outcome. Of 34 @entity0 operated <3 years after @entity4 onset, 30 (88%) achieved class I outcome. Thirty-seven (79%) of 47 @entity0 with lesional MRI had class-I outcome, whereas 9 (50%) of 18 with normal MRI had class I outcome. Positron emission tomography (PET) scan was abnormal in almost all @entity0 [61 (97%) of 63 with lateralizing/localizing findings in 56 (92%) of 61 @entity0 , thus helping in surgical decision making and guiding subdural grid placements, particularly in @entity0 with nonlesional MRI. Fifteen @entity0 had @entity2 , mostly minor. SIGNIFICANCE: @entity3 surgery in @entity3 @entity0 , with or without history of @entity5 , is best accomplished at an early age and in those @entity0 with @entity1 on MRI with electroencephalography (EEG) concordance. Good outcomes can be achieved even when there is no MRI lesion but positive PET localization.

title: Surgical treatment for refractory XXXX : The Detroit series.

answer: @entity3


abstract: UNASSIGNED: PURPOSE Of THE STUDy To compare the clinical results of @entity2 operated by superior locking plate using either horizontal or vertical incision by physical examination and nerve conduction tests. MATERIAL AnD METHODS Between January 2010 and January 2013, 63 @entity0 with displaced midshaft @entity2 were treated with superior locking plate (22 female, 41 male) with either horizontal (n = 38) or vertical incisions (n = 25). Mean interval between trauma and surgery was 3 days (1 to 8 days). Electrodiagnostic tests were performed to 15 @entity0 who felt @entity3 across their shoulder or chest and ASES test was performed to each of the @entity0 12 weeks postoperatively. IBM SPSS Statistics 22 (IBM SPSS, T  rkiye) programme was used for statistical analysis. Student t-test was used for comparison of normally distributed parameters (quantity) and continuity (yates) test was used. p < 0.05 was accepted to be statistically signifiant. RESULTS 8 @entity0 of the horizontal incision group and 7 @entity0 of the vertical incision group described @entity3 across their shoulders. 14 @entity0 had abnormal sensorial electrodiagnostic fidings. Comparison of electrodiagnostic fidings did not reveal any statistical signifiance. The mean ASES score of the affected shoulder was 76.39   1.20 in the horizontal group, in the vertical group it was found to be 79.00  2.5 ( p < 0.01). COnCLUSIOnS Electrodiagnostic study revealed similar results in both groups. According to these results, signifiant difference in mean ASES scores of both groups was not related to @entity4 . Key words: @entity2 , @entity1 .

title: XXXX after Surgical Treatment of @entity2 : Comparison of Two Incisions.

answer: @entity1


abstract: UNASSIGNED: PURPOSE Of THE STUDy To compare the clinical results of @entity2 operated by superior locking plate using either horizontal or vertical incision by physical examination and nerve conduction tests. MATERIAL AnD METHODS Between January 2010 and January 2013, 63 @entity0 with displaced midshaft @entity2 were treated with superior locking plate (22 female, 41 male) with either horizontal (n = 38) or vertical incisions (n = 25). Mean interval between trauma and surgery was 3 days (1 to 8 days). Electrodiagnostic tests were performed to 15 @entity0 who felt @entity3 across their shoulder or chest and ASES test was performed to each of the @entity0 12 weeks postoperatively. IBM SPSS Statistics 22 (IBM SPSS, T  rkiye) programme was used for statistical analysis. Student t-test was used for comparison of normally distributed parameters (quantity) and continuity (yates) test was used. p < 0.05 was accepted to be statistically signifiant. RESULTS 8 @entity0 of the horizontal incision group and 7 @entity0 of the vertical incision group described @entity3 across their shoulders. 14 @entity0 had abnormal sensorial electrodiagnostic fidings. Comparison of electrodiagnostic fidings did not reveal any statistical signifiance. The mean ASES score of the affected shoulder was 76.39   1.20 in the horizontal group, in the vertical group it was found to be 79.00  2.5 ( p < 0.01). COnCLUSIOnS Electrodiagnostic study revealed similar results in both groups. According to these results, signifiant difference in mean ASES scores of both groups was not related to @entity4 . Key words: @entity2 , @entity1 .

title: @entity1 after Surgical Treatment of XXXX : Comparison of Two Incisions.

answer: @entity2


abstract: OBJECTIVE: To determine the optimum time for @entity2 administration to minimize @entity1 during and after elective cesarean delivery. METHODS: A randomized clinical trial was conducted at Mansoura University Hospital, Egypt, between January 1, 2013, and December 31, 2014. Eligible @entity0 had full-term pregnancies, were scheduled to have a cesarean, and had normal fetal heart tracing. @entity0 were randomly allocated into two equal groups using computer-generated tables and sealed opaque envelopes. @entity2 (400 g, given rectally) was given either before (group 1) or after (group 2) surgery. @entity0 , investigators, and data analysts were not masked to group assignment. The primary outcome was @entity1 . RESULTS: A total of 348 @entity0 were included (174 in each group). @entity1 was significantly lower in group 1 than in group 2 (570  240 vs 844  270mL; P<0.001). The frequency of maternal and neonatal adverse events did not differ between the groups. CONCLUSION: Preoperative @entity2 (400 g, given rectally) reduces @entity1 to a greater extent than does postoperative @entity2 during elective cesarean delivery. The frequency of complications was not affected by time of administration.

title: A randomized clinical trial of preoperative versus postoperative XXXX in elective cesarean delivery.

answer: @entity2


abstract: Some properties of a one-stage, chromogenic clotting assay using tissue thromboplastin as an activator are described. The chromogenic assay uses @entity2 as substrate and estimates @entity0 by the rate of absorbance produced. Under assay conditions, it was observed that the log ( @entity0 or absorbance/min) is linear with time. The linearity appeared to extend from zero @entity0 up to maximum @entity0 concentration for all concentrations of each plasma type examined including factor V and @entity3 plasmas. Since the linear slope, b, appears to be a measure of the rate of @entity0 production, it was called the @entity5 ( @entity5 ). For dilutions of normal plasma log (b) appears to be linearly related to log (plasma concentration) and to log (PT) where PT is the standard one stage clotting time. For plasmas deficient in extrinsic clotting factors, b was linearly related to log (factor concentrations). The chromogenic assay was most sensitive to changes in prothrombin; least sensitive to changes in factor VII; and unaffected by changes in concentration of factors @entity1 and IX. The standard PT was least sensitive to prothrombin and more sensitive to factors X and VII. For oral anticoagulated plasmas log b and log PT were linearly correlated with a regression slope which was more negative than that from normal plasma. From theses results it was concluded that @entity5 is a chromogenic assay sensitive to all factors in the extrinsic pathway; that @entity5 might be used as both a screening assay for @entity4 and a monitoring assay for anticoagulants; and that @entity5 may be more sensitive than the standard PT to the defects from oral anticoagulation.

title: XXXX activation rate constant: one-stage chromogenic assay for the extrinsic system.

answer: @entity0


abstract: BACKGROUND: Rare mutations in the @entity3 -binding cassette (ABC) transporter A3 (ABCA3) gene are associated with neonatal @entity2 ( @entity2 ). The contribution of common single nucleotide polymorphisms (SNPs) to preterm @entity2 differs between ethnicities and remains unclear in Chinese @entity0 . This study evaluated whether common SNPs and consequent haplotypes increase susceptibility to @entity2 in a population of preterm @entity0 from the Guangxi Zhuang Autonomous Region of China. METHODS: Using a tagging SNP (tSNP) strategy and real-time polymerase chain reaction, we genotyped four tSNPs (i.e., @entity5 , @entity6 , @entity7 , and @entity8 ) and one coding SNP ( @entity9 ) of the ABCA3 gene in preterm @entity0 with @entity2 (n  =  83) and without @entity2 (n  =  83). We predicted the haplotypes. Minor allele frequencies (MAFs) and haplotype distributions were compared between the two groups. We analyzed correlations between the clinical data and the genotypes. RESULTS: Seven haplotypes existed at a frequency of 0.01 or greater. The haplotype TGGAG was significantly more frequent in @entity2 @entity0 than in non- @entity2 @entity0 (p  =  0.026; odds ratio 3.41; 95% confidence interval 1.088-10.685). The MAF of @entity8 SNP, a crucial SNP of the haplotype TGGAG located in the transcription factor binding site of ABCA3, was significantly higher in @entity2 @entity0 (p  <  0.05); however, the Bonferroni correction test showed no significant difference (p  >  0.05). No significant correlation existed between the @entity8 genotypes (AG/GG) and any clinical characteristic (e.g., @entity1 supplementation duration and hospitalization, requirement for ventilation, @entity4 , and mortality rate). CONCLUSION: The TGGAG haplotype may be a risk factor for @entity2 in preterm @entity0 in this Chinese population. Further study is needed with a larger sample size to verify the association between the @entity8 SNP and increased risk of @entity2 in preterm @entity0 , and to determine whether @entity8 can be a reference in further population-based studies of ABCA3.

title: The Haplotype TGGAG in the ABCA3 Gene Increases the Risk of Respiratory Distress Syndrome in Preterm XXXX in Southern China.

answer: @entity0


abstract: PURPOSE: @entity3 is essential for bone regeneration in @entity2 . This study aimed to investigate the microvascular morphology and distribution in the non-injured femur and the neovascularization of the metaphyseal critical size defect in a small animal model of @entity1 . MATERIALS AND METHODS: Female @entity0 (n=7) were ovariectomized (OVX) and received a multideficiency diet. Three months after OVX, a 5mm wedge shaped critical size defect was cut at the distal femoral metaphysis and stabilized with a T-shaped mini-plate. After six weeks, the animals were euthanized, and femora were removed and decalcified for micro-CT measurement of @entity2 . RESULTS: No @entity2 healing was observed along the critical size defects. In the non-injured bone, micro-vessel distribution showed a specific pattern, thereby enabling a differentiation between epi-, meta- and diaphysis. Micro-CT based morphometry revealed a significant reduction of the vascular volume fraction as well as the vascular thickness (p<0.001) in the critical size defect compared to the intact contralateral femur. Blood volume related vascular surface (vascular surface/volume) increased significantly (p<0.001). Connectivity density and tissue volume related vascular surface (vascular surface density) did not change significantly. CONCLUSIONS: Micro-CT based vascular morphometry demonstrated differences between epi-, meta- and diaphysis in the non-injured bone as well as differences between the critical size defect and the non-injured metaphysis. As angiogenesis is a crucial prerequisite that precedes osteogenesis, our results may influence further evaluation of osteoconductive or osteogenic biomaterials in this small animal model of @entity1 .

title: XXXX of osteoporotic metaphyseal bone defects: A morphometric micro-CT study.

answer: @entity3


abstract: @entity1 ( @entity1 ) cells are neurons found in the hippocampal formation and connected areas that fire as a function of an animal's directional orientation relative to its environment [1, 2]. They integrate self-motion and environmental sensory information to update directional heading [3]. @entity2 , in particular, exert strong control over the preferred direction of @entity1 cell firing [4]. The @entity1 signal has previously been shown to appear adult-like as early as postnatal day 16 (P16) in the @entity0 pup, just after eye opening and coinciding with the first spontaneous exploration of its environment [5, 6]. In order to determine whether the @entity1 circuit can begin its organization prior to the onset of patterned vision, we recorded from the anterodorsal thalamic nucleus (ADN) and its postsynaptic target in the hippocampal formation, the dorsal pre-subiculum (PrSd), before and after eye opening in pre-weanling @entity0 . We find that @entity1 cells can be recorded at the earliest age sampled (P12), several days before eye opening. However, this early @entity1 signal displays low directional information content and lacks stability both within and across trials. Following eye opening, the @entity1 system matures rapidly, as more cells exhibit directional firing, and the quality and reliability of the directional signal improves dramatically. Cue-rotation experiments show that a prominent visual landmark is able to control @entity1 responses within 24  hr of eye opening. Together, the results suggest that the directional network can be organized independently of visual spatial information while demonstrating the importance of patterned vision for accurate and reliable orientation in space.

title: The Development of the Head Direction System before Eye Opening in the XXXX .

answer: @entity0


abstract: Intense alkaline phosphatase (ALPase) activity has been localized in the outer plexiform layer of the developing @entity2 retina. To elucidate the functional significance of this enzymatic activity, we have injected an ALPase inhibitor, @entity3 , into @entity0 on either the 13th or 15th day of incubation. The retina was fixed between the 15th and 20th day of incubation and examined by electron microscopy. Levamisole injection on the 13th day caused various morphological alterations in retinal development, including the appearance of solitary photoreceptor cells in the subretinal space as well as folding of both the outer plexiform and outer nuclear layers. Pedicles of photoreceptor cells in the outer plexiform layer displayed rather smooth configurations with a reduced number of invaginations by post-synaptic neurites. The outer plexiform layer was thinned and the neuritic extensions in this layer appeared much less developed than in the control (PBS-injected) retina. Photoreceptor outer segments were seldom observed. Besides these alterations, layers of optic fibers and ganglion cells were also affected, as shown by evidence of degeneration in the ganglion cells and thinning of the nerve-fiber layer. Injection of levamisole into day 15 @entity0 exerted less influence on retinal development, but some photoreceptor cells were still found in the subretinal space. Some of these observations have been reported in the retinas of aged normal animals or in retinas with hereditary or induced @entity1 . It is suggested that ALPase activity in the outer plexiform layer of the developing @entity2 retina may be important for the onset of normal development of synapses in the outer plexiform layer and differentiation of the photoreceptor cells.

title: Alterations in the differentiation of XXXX retina caused by an intraocular injection of an alkaline phosphatase inhibitor.

answer: @entity2


abstract: BACKGROUND: We determined the epidemiological characteristics of @entity0 (EM)-resistant @entity1 (group A streptococci, GAS) strains isolated from Korea and Japan, using emm genotyping and multilocus sequence typing (MLST). METHODS: Clinical isolates of GAS had been collected from 1992 to 2012 in Korea and from 2004 to 2009 in Japan. EM resistance was determined by the microdilution method, and resistance genotypes were assessed by PCR. The emm genotyping and MLST were performed by DNA sequencing. RESULTS: The emm genotypes and sequence types (STs) were concordant in 143 (85.1%) of 168 EM-resistant GAS strains from Korea. ST36/emm12 (35.1%), @entity2 /emm28 (22.6%), and ST49/emm75 (16.1%) were the most common types. Most of the ST36 (93.9%) and @entity2 (95.8%) strains harbored erm(B), whereas strains ST49, ST42, and ST15 contained mef(A). The concordance between emm genotypes and STs was 41 (93.2%) among 44 EM-resistant GAS strains from Japan. ST36/emm12 (34.1%), ST49/emm75 (18.2%), and ST28/emm1 (15.9%) were the major types. ST36 isolates harbored either erm(B) (56.3%) or mef(A) (37.5%), whereas isolates ST28, ST49, and ST38 carried only mef(A). The proportion of erm(B) and mef(A) was 66.1% and 33.3% in Korea and 22.7% and 68.2% in Japan, respectively. CONCLUSIONS: The common STs in Korea and Japan were ST36 and ST49, whereas @entity2 was present only in Korea and ST28 only in Japan. Genotype erm(B) was predominant in Korea, whereas mef(A) was frequent in Japan. There were differences between Korea and Japan regarding the frequencies of emm genotypes, STs, and EM resistance genes among the EM-resistant GAS.

title: Epidemiological Study of XXXX -Resistant @entity1 From Korea and Japan by emm Genotyping and Multilocus Sequence Typing.

answer: @entity0


abstract: BACKGROUND: We determined the epidemiological characteristics of @entity0 (EM)-resistant @entity1 (group A streptococci, GAS) strains isolated from Korea and Japan, using emm genotyping and multilocus sequence typing (MLST). METHODS: Clinical isolates of GAS had been collected from 1992 to 2012 in Korea and from 2004 to 2009 in Japan. EM resistance was determined by the microdilution method, and resistance genotypes were assessed by PCR. The emm genotyping and MLST were performed by DNA sequencing. RESULTS: The emm genotypes and sequence types (STs) were concordant in 143 (85.1%) of 168 EM-resistant GAS strains from Korea. ST36/emm12 (35.1%), @entity2 /emm28 (22.6%), and ST49/emm75 (16.1%) were the most common types. Most of the ST36 (93.9%) and @entity2 (95.8%) strains harbored erm(B), whereas strains ST49, ST42, and ST15 contained mef(A). The concordance between emm genotypes and STs was 41 (93.2%) among 44 EM-resistant GAS strains from Japan. ST36/emm12 (34.1%), ST49/emm75 (18.2%), and ST28/emm1 (15.9%) were the major types. ST36 isolates harbored either erm(B) (56.3%) or mef(A) (37.5%), whereas isolates ST28, ST49, and ST38 carried only mef(A). The proportion of erm(B) and mef(A) was 66.1% and 33.3% in Korea and 22.7% and 68.2% in Japan, respectively. CONCLUSIONS: The common STs in Korea and Japan were ST36 and ST49, whereas @entity2 was present only in Korea and ST28 only in Japan. Genotype erm(B) was predominant in Korea, whereas mef(A) was frequent in Japan. There were differences between Korea and Japan regarding the frequencies of emm genotypes, STs, and EM resistance genes among the EM-resistant GAS.

title: Epidemiological Study of @entity0 -Resistant XXXX From Korea and Japan by emm Genotyping and Multilocus Sequence Typing.

answer: @entity1


abstract: OBJECTIVE: Physical exercise has been consistently documented as a complementary therapy in the treatment of @entity2 . However, despite a higher prevalence among @entity0 compared to @entity0 , the trials developed in @entity0 are scarce. In addition, the optimal dosage of exercise capable of producing benefits that reduce @entity2 remains unclear. This clinical trial is designed to measure the effect of a structured physical exercise program as a complement to antidepressant medication in the treatment of @entity0 with @entity2 . METHODS: From July 2013 to May 2014, we implemented a randomized controlled trial (HAPPY BRAIN study). A total of 26 @entity0 (aged 50.16      12.08) diagnosed with clinical @entity2 were randomized either to a supervised aerobic exercise group (45-50  min/week three times a week for four months) plus pharmacotherapy (intervention group), or only antidepressant medication (control group). RESULTS: The exercise group presented a decrease in BDI-II and DASS-21 total score scales. Relatively to DASS-21, it showed a significant decrease in @entity1 and stress. The exercise group when compared to a control group showed improvement in relation to physical functioning parameters between baseline and post-intervention. Moreover, anthropometric parameters presented only significant differences between groups in fat mass percentage. Nonetheless, no differences were found between groups in weight, body mass index, waist circumference, and self-esteem. CONCLUSION: Our results showed that supervised structured aerobic exercise training could be an effective adjuvant therapy for treating @entity0 with @entity2 , reducing depressive symptomatology and improving physical fitness. A key factor of this improvement included strict control of exercise workload parameters and adjustment to each subject's capacity. In our study, due to the sample size there is an increase in the probability of @entity3 .

title: Effects of structured exercise and pharmacotherapy vs. pharmacotherapy for adults with XXXX : A randomized clinical trial.

answer: @entity2


abstract: Toxicogenomics is proposed to be a useful tool in @entity0 health risk assessment. However, a systematic comparison of traditional risk assessment approaches with those applying toxicogenomics has never been done. We conducted a case study to evaluate the utility of toxicogenomics in the risk assessment of @entity2 ( @entity3 ), a well-studied carcinogen, for drinking water exposures. Our study was intended to compare methodologies, not to evaluate drinking water safety. We compared traditional ( @entity4 ), genomics-informed ( @entity5 ) and genomics-only ( @entity6 ) approaches. @entity5 and @entity6 applied toxicogenomics data from @entity0 cell cultures and @entity1 exposed to @entity3 to determine if these data could provide insight into @entity3 's mode of action (MOA) and derive tissue-specific points of departure (POD). Our global gene expression analysis supported that @entity3 is genotoxic in @entity1 and allowed the development of a detailed MOA. Toxicogenomics analysis in @entity0 lymphoblastoid TK6 cells demonstrated a high degree of consistency in perturbed pathways with animal tissues. Quantitatively, the PODs for traditional and transcriptional approaches were similar (liver 1.2 vs. 1.0 mg/kg-bw/day; lungs 0.8 vs. 3.7 mg/kg-bw/day; forestomach 0.5 vs. 7.4 mg/kg-bw/day). @entity6 , which applied toxicogenomics in the absence of apical toxicology data, demonstrates that this approach provides useful information in data-poor situations. Overall, our study supports the use of toxicogenomics as a relatively fast and cost-effective tool for hazard identification, preliminary evaluation of potential carcinogens, and carcinogenic potency, in addition to identifying current limitations and practical questions for future work.

title: Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in @entity0 health risk assessment of XXXX in drinking water.

answer: @entity2


abstract: Toxicogenomics is proposed to be a useful tool in @entity0 health risk assessment. However, a systematic comparison of traditional risk assessment approaches with those applying toxicogenomics has never been done. We conducted a case study to evaluate the utility of toxicogenomics in the risk assessment of @entity2 ( @entity3 ), a well-studied carcinogen, for drinking water exposures. Our study was intended to compare methodologies, not to evaluate drinking water safety. We compared traditional ( @entity4 ), genomics-informed ( @entity5 ) and genomics-only ( @entity6 ) approaches. @entity5 and @entity6 applied toxicogenomics data from @entity0 cell cultures and @entity1 exposed to @entity3 to determine if these data could provide insight into @entity3 's mode of action (MOA) and derive tissue-specific points of departure (POD). Our global gene expression analysis supported that @entity3 is genotoxic in @entity1 and allowed the development of a detailed MOA. Toxicogenomics analysis in @entity0 lymphoblastoid TK6 cells demonstrated a high degree of consistency in perturbed pathways with animal tissues. Quantitatively, the PODs for traditional and transcriptional approaches were similar (liver 1.2 vs. 1.0 mg/kg-bw/day; lungs 0.8 vs. 3.7 mg/kg-bw/day; forestomach 0.5 vs. 7.4 mg/kg-bw/day). @entity6 , which applied toxicogenomics in the absence of apical toxicology data, demonstrates that this approach provides useful information in data-poor situations. Overall, our study supports the use of toxicogenomics as a relatively fast and cost-effective tool for hazard identification, preliminary evaluation of potential carcinogens, and carcinogenic potency, in addition to identifying current limitations and practical questions for future work.

title: Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in XXXX health risk assessment of @entity2 in drinking water.

answer: @entity0


abstract: Objectives. This study was conducted to verify the necessity of corresponding prescription to the diagnosed pattern in acute @entity2 @entity0 . Methods. We studied @entity2 @entity0 hospitalized within 30 days after the ictus. Forty-four clinical indicators, @entity3 ( @entity3 ) score, Scandinavian @entity1 Scale (SSS) score, and herbal prescriptions were checked twice, two weeks apart. The probability of each pattern was calculated based on the clinical indicators. Changes in @entity3 score, SSS score, and the probability of fire-heat pattern were compared between the pattern-prescription correspondence group and the noncorrespondence group. Results. Increments of @entity3 score and SSS score in the correspondence group were significantly greater than those of the noncorrespondence group (p = 0.003, p = 0.001) while the baseline score of the two groups showed no significant difference. Probability of fire-heat pattern decreased significantly in the correspondence group (p = 0.013) while the noncorrespondence group showed no significant difference after the treatment. Conclusion. Acute @entity2 @entity0 who are diagnosed as fire-heat pattern showed better improvement in dysfunctions caused by the disease when they took the pattern corresponding prescriptions. This study provides evidence for the necessity and usefulness of pattern identification in Traditional Korean Medicine.

title: Effect of Herbal Prescriptions in Accordance with Pattern Identification in Acute XXXX @entity0 : Based on Fire-Heat Pattern.

answer: @entity2


abstract: Objectives. This study was conducted to verify the necessity of corresponding prescription to the diagnosed pattern in acute @entity2 @entity0 . Methods. We studied @entity2 @entity0 hospitalized within 30 days after the ictus. Forty-four clinical indicators, @entity3 ( @entity3 ) score, Scandinavian @entity1 Scale (SSS) score, and herbal prescriptions were checked twice, two weeks apart. The probability of each pattern was calculated based on the clinical indicators. Changes in @entity3 score, SSS score, and the probability of fire-heat pattern were compared between the pattern-prescription correspondence group and the noncorrespondence group. Results. Increments of @entity3 score and SSS score in the correspondence group were significantly greater than those of the noncorrespondence group (p = 0.003, p = 0.001) while the baseline score of the two groups showed no significant difference. Probability of fire-heat pattern decreased significantly in the correspondence group (p = 0.013) while the noncorrespondence group showed no significant difference after the treatment. Conclusion. Acute @entity2 @entity0 who are diagnosed as fire-heat pattern showed better improvement in dysfunctions caused by the disease when they took the pattern corresponding prescriptions. This study provides evidence for the necessity and usefulness of pattern identification in Traditional Korean Medicine.

title: Effect of Herbal Prescriptions in Accordance with Pattern Identification in Acute @entity2 XXXX : Based on Fire-Heat Pattern.

answer: @entity0


abstract: @entity3 is a very rare disorder of autosomal recessive inheritance distinguished by @entity6 and early onset of @entity4 affecting the dentition. Genetic studies have identified a mutation in the major gene locus of chromosome 11q14 with loss of function. @entity5 gene is to be responsible for @entity3 . The present case report describes a 13-year-old female, who visited the Department of Periodontology with the chief compliant of bleeding gums and loose teeth. She presented with the signs and symptoms of @entity3 . The @entity0 had premature shedding of her deciduous dentition. On clinical examination, extraorally, the @entity0 presented with persistent thickening, flaking, and scaling of the skin of palms and soles. Her intraoral examination revealed @entity1 , abscess formation, and periodontal pockets. Her intraoral radiographs showed @entity2 involving the central incisors and molars. The @entity0 underwent periodontal therapy and is under maintenance.

title: XXXX : Periodontists' Perspective.

answer: @entity3


abstract: Objectives. To assess cardiovascular risk factors in Nepalese population with @entity4 as compared to age and sex matched controls. Materials and Methods. A case control study was conducted among 200 subjects (100 @entity4 and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free @entity6 (fT3), free @entity7 (fT4), thyroid stimulating hormone (TSH), total @entity2 (TC), high density lipoprotein @entity2 (HDL-C), low density lipoprotein @entity2 (LDL-C), and high sensitivity @entity5 (hs-CRP). Results. @entity4 @entity0 had significantly higher diastolic BP, total @entity2 , LDL @entity2 , and hs-CRP than controls. The odds ratio of having @entity3 (>200   mg/dL), low HDL @entity2 (<40   mg/dL), undesirable LDL- @entity2 (>100   mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI >=  23   Kg/m(2)) in @entity4 was 2.29 (95% CI; 1.2-4.38, p = 0.011), 1.73 (95% CI; 0.82-3.62, p = 0.141), 3.04 (95% CI; 1.66-5.56, p < 0.001), 2.02 (95% CI; 1.12-3.64, p = 0.018), 3.35 (95% CI; 1.72-6.55, p < 0.001), and 0.9 (95% CI; 0.48-1.67, p = 0.753), respectively, as compared to controls. Conclusion. @entity4 @entity0 are associated with higher risk for @entity1 than euthyroid subjects.

title: Cardiovascular Risk Factors in XXXX : A Case Control Study in Nepalese Population.

answer: @entity4


abstract: BACKGROUND: Injuries among welders are an important health issue in metal industries at global level. The study aimed to assess the prevalence and pattern of @entity0 and its possible associated risk factors among welders. MATERIALS AND METHODS: A cross-sectional study was conducted among 209 welders in metal industries of Puducherry, @entity4 India. Data regarding all types of @entity0 during the past 1 year were collected by administering a pre-designed questionnaire. The various risk factors associated with @entity0 that include age, training before induction, experience, job duration, @entity2 chewing, @entity1 use and use of protective measures were assessed using standard questionnaire. The data was analyzed by univariate and multiple logistic regression analysis. RESULTS: Majority of subjects were aged between 20 and 40 years (160, 76.6%) and educated below 10(th) standard (181, 86.6%). Mean number of injury was found to be 10.74 (SD = 5.74) in the preceding year. All of them had more than 2 @entity0 and 44% (92) of them had more than 10 @entity0 . All of them had abrasions and more than three fourths of them had each of lacerations, foreign @entity3 , flash @entity5 . Multiple logistic regression analysis showed that age less than 30 years (OR = 5.19), @entity2 use (OR = 2.56), @entity1 use (OR = 3.96) and institutional training (OR = 0.10) were the predictors associated with more than 10 @entity0 among welders. CONCLUSION: Injury among welders is an important health problem in this area. Strategies for strengthening institutional training for younger age groups may help in decreasing the burden of @entity0 .

title: Prevalence and pattern of occupational injuries at workplace among welders in XXXX India.

answer: @entity4


abstract: OBJECTIVES: To evaluate treatment compliance to weekly concurrent chemoradiotherapy (CRT) in @entity3 ( @entity3 ). STUDY DESIGN: Retrospective analysis. SETTING: Tertiary care hospital. MAIN OUTCOME MEASURES: Overall treatment time (OTT), acute radiation morbidity and treatment completion rate without prolongation of overall treatment time of more than 2 days. RESULTS: Three hundred and seventy-eight @entity2 @entity0 treated with radical CRT with 70 Gy/35 fractions of radiotherapy with weekly @entity4 40 mg/m(2) were included in the study. Median age was 52 years (range 22-77 years), oropharynx was most commonly (54%) involved site, and 55% were in stage IV disease. Majority (86%) of @entity0 were able to complete @entity1 -directed therapy, median OTT was 52 days (46-140 days). Nineteen per cent of @entity0 completed treatment without prolongation of OTT beyond 2 days and 68% of @entity0 there completed treatment prolongation of OTT beyond 7 days. Nearly, sixty-six of the @entity0 experienced grade II or higher acute radiation morbidities. CONCLUSIONS: Delivery of weekly low-dose concurrent CRT is safe and feasible. Two-thirds of the @entity0 experienced treatment prolongation of more than 2 days and 14% could not complete treatment. Results within in the study suggest to a greater need to lay emphasis on continuity of a course of radical CRT for @entity3 .

title: Six-year analysis of compliance to weekly concurrent chemoradiotherapy in XXXX .

answer: @entity2


abstract: INTRODUCTION: Neonatal @entity3 is closely related to gestational age and mode of birth. Lowest gestational ages and caesarean section are associated with higher risk of developing @entity3 . The efficacy of antenatal @entity1 is well established in the induction of lung maturation in premature births. Its use could be a beneficial intervention in term fetuses that will be born by elective caesarean section. OBJECTIVE: To find the best evidence available to determine whether the use of antenatal @entity1 reduces the incidence of @entity3 in term babies born by elective caesarean section. METHODOLOGY: We searched the available medical literature in different databases: PubMed, LILACS, UpToDate, @entity5 database, Scielo and Cochrane. We considered controlled, randomized therapeutic studies, performed on @entity0 , in which the intervention included @entity1 as a treatment in elective term cesareans. RESULTS: We selected two studies. In both, the intervention was two doses of 12 mg of @entity2 before the caesarean section. The primary objective in both studies was to analyze the incidence of @entity3 and the admission of the newborn into intensive care units. In both studies, there was less incidence of @entity4 @entity3 , with statistically significant results. CONCLUSIONS: We concluded that the use of @entity1 in elective term caesarean section reduces the incidence of @entity4 @entity3 and the admission into intensive care units. However, we evidenced certain weaknesses that could modify the internal validity of both studies, so it is necessary to develop new studies that could support these findings in order to modify clinical protocols in term elective caesarean sections.

title: [Do antenatal XXXX in term elective cesarean sections reduce @entity4 respiratory morbidity?]

answer: @entity1


abstract: INTRODUCTION: Neonatal @entity3 is closely related to gestational age and mode of birth. Lowest gestational ages and caesarean section are associated with higher risk of developing @entity3 . The efficacy of antenatal @entity1 is well established in the induction of lung maturation in premature births. Its use could be a beneficial intervention in term fetuses that will be born by elective caesarean section. OBJECTIVE: To find the best evidence available to determine whether the use of antenatal @entity1 reduces the incidence of @entity3 in term babies born by elective caesarean section. METHODOLOGY: We searched the available medical literature in different databases: PubMed, LILACS, UpToDate, @entity5 database, Scielo and Cochrane. We considered controlled, randomized therapeutic studies, performed on @entity0 , in which the intervention included @entity1 as a treatment in elective term cesareans. RESULTS: We selected two studies. In both, the intervention was two doses of 12 mg of @entity2 before the caesarean section. The primary objective in both studies was to analyze the incidence of @entity3 and the admission of the newborn into intensive care units. In both studies, there was less incidence of @entity4 @entity3 , with statistically significant results. CONCLUSIONS: We concluded that the use of @entity1 in elective term caesarean section reduces the incidence of @entity4 @entity3 and the admission into intensive care units. However, we evidenced certain weaknesses that could modify the internal validity of both studies, so it is necessary to develop new studies that could support these findings in order to modify clinical protocols in term elective caesarean sections.

title: [Do antenatal @entity1 in term elective cesarean sections reduce XXXX respiratory morbidity?]

answer: @entity4


abstract: OBJECTIVE: To assess @entity2 in endodontic therapy and its association with clinical factors such as gender, age, tooth type, pulpal diagnosis, and @entity1 , @entity5 and sealer extrusion. STUDY DESIGN: Cross-Sectional study. PLACE AND DURATION OF STUDY: Dental section of the Aga khan university hospital, Karachi, Pakistan from January to December 2009. METHODOLOGY: One hundred and forty @entity0 (140) requiring endodontic therapy for @entity3 were included in this study. Local Anesthesia (2% Lidocain with 1:80,000 Epinephrine) was administered. The tooth was isolated with rubber dam. Access cavity was prepared with the help of round carbide No. 2 bur. Canal preparation was completed using crown-down technique. Access was sealed with sterile dry @entity4 pallet and restored temporarily with double layer of Glass ionomer cement and Cavit. After one week @entity0 were recalled and access was re-opened, obturation was done using cold lateral condensation technique. Ca(OH)(2) based sealer was used. Postoperative radiographs were taken. @entity0 were recalled after 24 hours and @entity1 was recorded using Visual analogue scale (VAS).Data was obtained on a structured Performa.   (2) test was used for statistical analysis. RESULTS: @entity1 was present in 42.9% of @entity0 . Females more frequently experienced @entity1 (65%) than males (35%). @entity1 was found to be significantly associated with @entity2 (p value < 0.001). Obturation length was not found to be significantly associated with @entity2 (p value 1.0). Sealer extrusion was not found to be significantly associated with postoperative (P value 0.547).

title: Factors associated with XXXX in endodontic therapy.

answer: @entity2


abstract: INTRODUCTION: @entity0 is the most common @entity3 in @entity1 . Unlike IDC, which typically metastasizes to the lung, liver or bone, ILC has been found to metastasize to GI tract, peritoneum and retroperitoneum. Nonspecific symptomology may be considered secondary to other diseases and this can delay the definite diagnosis and treatment of @entity2 . Knowledge of the pattern of disease spread is essential for accurate diagnosis and early initiation of systemic treatment, thus avoiding unnecessary interventions. We are reporting three unique cases of metastatic ILC presenting with wide range of symptoms. CASE PRESENTATIONS: Case A: 69-year-old female presented with recurrent @entity5 . Case B: 77-year-old female with the past medical history of right breast ILC seven years ago status post right radical mastectomy with chemotherapy, presented with @entity4 . Case C: 56-year-old female presented with bright red blood per rectum. CONCLUSION: A high level of suspicion is needed for metastatic @entity0 in @entity1 with history of ILC, regardless of disease free interval. Since it frequently metastasizes to unusual sites and presents with a wide spectrum of symptoms.

title: Unique presentations of XXXX : a case series.

answer: @entity0


abstract: The liver is the organ usually affected by metastatic @entity2 (MUM). Current treatments are almost always ineffective and mortality remains high. In this study, copy number variations (CNVs) were identified in 12 metastatic and five matched primary UMs (PUMs). Our data revealed a wide spectrum of genetic alterations in MUM. Most common were amplifications of chromosome (chr.) 8q; alterations on chr. 3 included monosomy, isodisomy, and large regions of homozygosity (ROH). Genomic profiles of @entity3 -MUM pairs varied in their degree of similarity and complexity. However, within the pairs, 135 genes were consistently altered. Protein expression of @entity1 and @entity4 was examined by immunohistochemistry (IHC); a positive association between IHC and CNVs was seen for @entity1 . This comprehensive catalogue of CNVs associated with MUM should facilitate the identification of key alterations that drive @entity0 growth. This would have the potential to select urgently needed novel, targeted, therapeutic regimens.

title: Insights into genetic alterations of liver metastases from XXXX .

answer: @entity2


abstract: CONTEXT: @entity7 ( @entity7 ) is a life-threatening condition that is often due to monogenic causes in @entity0 . Although @entity2 occurs commonly, several other important molecular causes have been reported, often with overlapping clinical and biochemical features. The relative prevalence of these conditions is not known, but making a specific diagnosis can have important implications for management. OBJECTIVE: The objective of the study was to investigate the clinical and molecular genetic characteristics of a nationwide cohort of @entity0 with @entity7 of unknown etiology. DESIGN: A structured questionnaire was used to evaluate clinical, biochemical, and imaging data. Genetic analysis was performed using Haloplex capture and next-generation sequencing. @entity0 with @entity2 , @entity9 , @entity3 , or obvious syndromic @entity7 were excluded. SETTING: The study was conducted in 19 tertiary pediatric endocrinology clinics. @entity0 : Ninety-five @entity0 (48 females, aged 0-18 y, eight familial) with @entity7 of unknown etiology participated in the study. RESULTS: A genetic diagnosis was obtained in 77 @entity0 (81%). The range of etiologies was as follows: @entity5 (n = 25), @entity4 (n = 12), @entity1 (n = 11), @entity8 (n = 9), @entity6 (n = 9), NNT (n = 7), @entity12 (n = 2), @entity10 (n = 1), and @entity11 (n = 1). Recurrent mutations occurred in several genes, such as @entity13 in @entity5 , @entity14 in @entity8 , and @entity15 in @entity6 . Several important clinical and molecular insights emerged. CONCLUSION: This is the largest nationwide study of the molecular genetics of childhood @entity7 undertaken. Achieving a molecular diagnosis in more than 80% of @entity0 has important translational impact for counseling families, presymptomatic diagnosis, personalized treatment (eg, mineralocorticoid replacement), predicting comorbidities (eg, neurological, puberty/fertility), and targeting clinical genetic testing in the future.

title: Rare Causes of Primary XXXX : Genetic and Clinical Characterization of a Large Nationwide Cohort.

answer: @entity3


abstract: UNASSIGNED: @entity8 ( @entity8 ) is a rare, underreported, and often misdiagnosed @entity2 of the sweat glands. It is often located on the digits and toes and most commonly occurs in male individuals in their fifties to seventies. Because of lack of @entity4 , slow growth, and an inconspicuous appearance, clinical diagnosis is often missed or delayed. In contrast, @entity12 ( @entity12 ) is a cystic @entity5 that arises from the apocrine secretory coil, and it is extremely rare for AHs to develop on the digits. We report 7 cases of @entity8 , including clinical course, histopathologic and immunohistochemical findings, and therapeutic approach in which the initial histopathologic diagnosis in all cases was @entity12 or @entity11 . However, complete excision of the @entity2 led to a final diagnosis of @entity8 . After an adequate treatment, no recurrence or @entity1 was found in any of the cases described. All the cases studied showed similar histopathologic and immunohistochemical findings. The initial incisional biopsy showed large unilocular or multilocular cystic spaces situated within the dermis, lined by a double layer of epithelial cells with tiny papillary structures. No cellular atypia, @entity3 , or pleomorphism was observed. However, complete excision revealed @entity7 involving the dermis and/or subcutis, with an infiltrative pattern and papillary projections into luminal spaces. Immunoperoxidase studies showed positivity for @entity10 , S-100 protein, @entity6 , @entity9 , smooth muscle actin, and calponin. @entity8 is a rare but life-threatening malignancy, therefore it is important to be able to identify such a lesion both clinically and histopathologically, treat it, and monitor the @entity0 for the @entity2 's potential recurrence and @entity1 . Pathologists and dermatopathologists should be aware that a histopathologic diagnosis of @entity12 or @entity11 on the fingers and toes should be established with caution, because probably those lesions represent the superficial and cystic component of an underlying @entity8 , and a wider excision should be performed.

title: "Apocrine XXXX and @entity2 : A Potential Diagnostic Pitfall of Digital Papillary Adenocarcinoma.

answer: @entity12


abstract: UNASSIGNED: @entity8 ( @entity8 ) is a rare, underreported, and often misdiagnosed @entity2 of the sweat glands. It is often located on the digits and toes and most commonly occurs in male individuals in their fifties to seventies. Because of lack of @entity4 , slow growth, and an inconspicuous appearance, clinical diagnosis is often missed or delayed. In contrast, @entity12 ( @entity12 ) is a cystic @entity5 that arises from the apocrine secretory coil, and it is extremely rare for AHs to develop on the digits. We report 7 cases of @entity8 , including clinical course, histopathologic and immunohistochemical findings, and therapeutic approach in which the initial histopathologic diagnosis in all cases was @entity12 or @entity11 . However, complete excision of the @entity2 led to a final diagnosis of @entity8 . After an adequate treatment, no recurrence or @entity1 was found in any of the cases described. All the cases studied showed similar histopathologic and immunohistochemical findings. The initial incisional biopsy showed large unilocular or multilocular cystic spaces situated within the dermis, lined by a double layer of epithelial cells with tiny papillary structures. No cellular atypia, @entity3 , or pleomorphism was observed. However, complete excision revealed @entity7 involving the dermis and/or subcutis, with an infiltrative pattern and papillary projections into luminal spaces. Immunoperoxidase studies showed positivity for @entity10 , S-100 protein, @entity6 , @entity9 , smooth muscle actin, and calponin. @entity8 is a rare but life-threatening malignancy, therefore it is important to be able to identify such a lesion both clinically and histopathologically, treat it, and monitor the @entity0 for the @entity2 's potential recurrence and @entity1 . Pathologists and dermatopathologists should be aware that a histopathologic diagnosis of @entity12 or @entity11 on the fingers and toes should be established with caution, because probably those lesions represent the superficial and cystic component of an underlying @entity8 , and a wider excision should be performed.

title: "Apocrine @entity12 and XXXX : A Potential Diagnostic Pitfall of Digital Papillary Adenocarcinoma.

answer: @entity2


abstract: UNASSIGNED: Forty entire male @entity3 from a commercial crossbreed (Duroc * Large White * Landrace) were used to investigate the individual or combined effects of @entity5 and @entity1 supplementation in Lys-deficient diets on growth performance, carcass traits, and pork quality. @entity3 with 59.9    1.65 kg BW were randomly assigned to 1 of 5 dietary treatments ( = 8). The 5 dietary treatments were normal Lys and CP diet (0.51% Lys and 16% CP; control), reduced Lys and CP diet (0.35% Lys and 13% CP), reduced Lys and CP diet with @entity5 supplementation (0.33%), reduced Lys and CP diet with @entity1 supplementation (1.5%), and reduced Lys and CP diet with @entity5 and @entity1 supplementation (0.33% @entity5 and 1.5% @entity1 ). @entity3 were slaughtered at 92.7    2.54 kg BW. The Lys-deficient diets (-35% Lys) increased intramuscular fat (IMF) content by 25% ( = 0.041) and meat juiciness by 12% ( = 0.041) but had a negative effect on growth performance ( < 0.05) of @entity3 . In addition, Lys-deficient diets increased L* ( = 0.005) and b* ( = 0.010) muscle color parameters and perirenal fat deposition ( < 0.001) and decreased both HCW ( = 0.015) and loin weight ( = 0.023). @entity5 and @entity1 supplementation of Lys-deficient diets had no effect on IMF content but increased ( < 0.05) overall pork acceptability. @entity0 supplementation also increased ( = 0.003) meat tenderness. Differences in @entity2 composition of pork were not detected among dietary treatment groups. However, @entity4 was positively correlated ( < 0.05) with IMF content, juiciness, flavor, and overall acceptability of meat. Data confirm that dietary CP reduction enhances pork eating quality but negatively affects @entity3 ' growth performance. Moreover, it is suggested that @entity5 and @entity1 supplementation of Lys-deficient diets does not further increase IMF content but improves some pork sensory traits, including overall acceptability.

title: Effect of XXXX and @entity0 in lysine-deficient diets on growth, carcass traits, and pork quality.

answer: @entity5


abstract: UNASSIGNED: Forty entire male @entity3 from a commercial crossbreed (Duroc * Large White * Landrace) were used to investigate the individual or combined effects of @entity5 and @entity1 supplementation in Lys-deficient diets on growth performance, carcass traits, and pork quality. @entity3 with 59.9    1.65 kg BW were randomly assigned to 1 of 5 dietary treatments ( = 8). The 5 dietary treatments were normal Lys and CP diet (0.51% Lys and 16% CP; control), reduced Lys and CP diet (0.35% Lys and 13% CP), reduced Lys and CP diet with @entity5 supplementation (0.33%), reduced Lys and CP diet with @entity1 supplementation (1.5%), and reduced Lys and CP diet with @entity5 and @entity1 supplementation (0.33% @entity5 and 1.5% @entity1 ). @entity3 were slaughtered at 92.7    2.54 kg BW. The Lys-deficient diets (-35% Lys) increased intramuscular fat (IMF) content by 25% ( = 0.041) and meat juiciness by 12% ( = 0.041) but had a negative effect on growth performance ( < 0.05) of @entity3 . In addition, Lys-deficient diets increased L* ( = 0.005) and b* ( = 0.010) muscle color parameters and perirenal fat deposition ( < 0.001) and decreased both HCW ( = 0.015) and loin weight ( = 0.023). @entity5 and @entity1 supplementation of Lys-deficient diets had no effect on IMF content but increased ( < 0.05) overall pork acceptability. @entity0 supplementation also increased ( = 0.003) meat tenderness. Differences in @entity2 composition of pork were not detected among dietary treatment groups. However, @entity4 was positively correlated ( < 0.05) with IMF content, juiciness, flavor, and overall acceptability of meat. Data confirm that dietary CP reduction enhances pork eating quality but negatively affects @entity3 ' growth performance. Moreover, it is suggested that @entity5 and @entity1 supplementation of Lys-deficient diets does not further increase IMF content but improves some pork sensory traits, including overall acceptability.

title: Effect of @entity5 and XXXX in lysine-deficient diets on growth, carcass traits, and pork quality.

answer: @entity0


abstract: UNASSIGNED: This study investigated effects of stocking rate on @entity0 performance, quality and quantity of @entity2 residue, and impact of residue removal on grain yield for 5 yr at the University of Nebraska - Lincoln West Central Water Resources Field Laboratory near Brule, NE. Four removal treatments-1) no removal (control), 2) grazing at 2.5 animal unit month (AUM)/ha, 3) grazing at 5.0 AUM/ha, and 4) baling-were applied to a center pivot-irrigated @entity2 field (53 ha). The field was divided into eight 6.6-ha paddocks to which replicated treatments were assigned. Samples of residue were collected in October and March (before and after residue removal) using ten 0.5-m quadrats per treatment replication. Residue was separated into 5 plant parts-stem, cob, leaf, husk, and grain-and analyzed for nutrient content. Esophageally fistulated @entity0 were used to measure diet quality. @entity0 assigned to the 2.5 AUM/ha stocking rate treatment gained more BW ( < 0.01) and BCS ( < 0.01) than @entity0 assigned to the 5.0 AUM/ha treatment. Leaf contained the most ( < 0.01) CP and husk had the greatest ( < 0.01) @entity1 ( @entity1 ) but the CP and @entity1 of individual plant parts did not differ ( > 0.69) between sampling dates. Amount of total residue was reduced ( < 0.05) by baling and both grazing treatments between October and March but was not different ( > 0.05) in control paddocks between sampling dates. As a proportion of the total residue, stem increased ( < 0.01) and husk decreased ( < 0.01) between October and March. Diet CP content was similar ( = 0.10) between sampling dates for the 2 grazing treatments but @entity1 was greater after grazing in the 2.5 AUM/ha grazing treatment ( = 0.04). Subsequent grain yields were not different ( = 0.16) across all 4 residue removal treatments. At the proper stocking rate, @entity2 residue grazing results in acceptable animal performance without negatively impacting subsequent @entity2 grain production.

title: @entity2 residue stocking rate affects XXXX performance but not subsequent grain yield.

answer: @entity0


abstract: UNASSIGNED: This study investigated effects of stocking rate on @entity0 performance, quality and quantity of @entity2 residue, and impact of residue removal on grain yield for 5 yr at the University of Nebraska - Lincoln West Central Water Resources Field Laboratory near Brule, NE. Four removal treatments-1) no removal (control), 2) grazing at 2.5 animal unit month (AUM)/ha, 3) grazing at 5.0 AUM/ha, and 4) baling-were applied to a center pivot-irrigated @entity2 field (53 ha). The field was divided into eight 6.6-ha paddocks to which replicated treatments were assigned. Samples of residue were collected in October and March (before and after residue removal) using ten 0.5-m quadrats per treatment replication. Residue was separated into 5 plant parts-stem, cob, leaf, husk, and grain-and analyzed for nutrient content. Esophageally fistulated @entity0 were used to measure diet quality. @entity0 assigned to the 2.5 AUM/ha stocking rate treatment gained more BW ( < 0.01) and BCS ( < 0.01) than @entity0 assigned to the 5.0 AUM/ha treatment. Leaf contained the most ( < 0.01) CP and husk had the greatest ( < 0.01) @entity1 ( @entity1 ) but the CP and @entity1 of individual plant parts did not differ ( > 0.69) between sampling dates. Amount of total residue was reduced ( < 0.05) by baling and both grazing treatments between October and March but was not different ( > 0.05) in control paddocks between sampling dates. As a proportion of the total residue, stem increased ( < 0.01) and husk decreased ( < 0.01) between October and March. Diet CP content was similar ( = 0.10) between sampling dates for the 2 grazing treatments but @entity1 was greater after grazing in the 2.5 AUM/ha grazing treatment ( = 0.04). Subsequent grain yields were not different ( = 0.16) across all 4 residue removal treatments. At the proper stocking rate, @entity2 residue grazing results in acceptable animal performance without negatively impacting subsequent @entity2 grain production.

title: XXXX residue stocking rate affects @entity0 performance but not subsequent grain yield.

answer: @entity2


abstract: BACKGROUND: Given the clinical practice of prescribing physical rehabilitation for the treatment of @entity1 , the present study examined the functional and histomorphological adaptations in the volumetric muscle loss (VML) injured muscle to physical rehabilitation. METHODS: Tibialis anterior muscle VML injury was created in Lewis @entity0 (n   =   32), and were randomly assigned to either sedentary (SED) or physical rehabilitation (RUN) group. After 1  week, RUN @entity0 were given unlimited access to @entity6 wheels either 1 or 7  weeks (2 or 8  weeks @entity2 ). At 2  weeks @entity2 , TA muscles were harvested for molecular analyses. At 8  weeks @entity2 , the @entity0 underwent in vivo function testing. The explanted tissue was analyzed using histological and immunofluorescence procedures. RESULTS: The primary findings of the study are that physical rehabilitation in the form of @entity6 promotes   ~   17% improvement in maximal isometric torque, and a   ~   13% increase in weight of the injured muscle, but it did so without significant morphological adaptations (e.g., no @entity3 and @entity4 ). Wheel running up-regulated metabolic genes ( @entity8 , @entity7 ) only in the uninjured muscles, and a greater deposition of fibrous tissue in the defect area of the injured muscle preceded by an up-regulation of pro-fibrotic genes (Collagen I, @entity5 ). Therefore, it is plausible that the wheel running related functional improvements were due to improved force transmission and not muscle regeneration. CONCLUSIONS: This is the first study to demonstrate improvement in functional performance of non-repaired VML injured muscle with physical rehabilitation in the form of @entity6 . This study provides information for the first time on the basic changes in the VML injured muscle with physical rehabilitation, which may aid in the development of appropriate physical rehabilitation regimen(s).

title: Physical rehabilitation improves muscle function following volumetric XXXX .

answer: @entity1


abstract: UNASSIGNED: Botulinum neurotoxins (BoNTs) are highly potent bacterial proteins that block neurotransmitter release at the neuromuscular junction by cleaving SNAREs (soluble @entity3 sensitive factor attachment protein receptors). However, their serotype A (BoNT/A) that cleaves @entity4 ( @entity4 ) has also been an established pharmaceutical for treatment of medical conditions that rely on hyperactivity of cholinergic nerve terminals for 25years. The expansion of its use to a variety of further medical conditions associated with hypersecretion components is prevented partly because the involved SNARE isoforms are not cleaved. Therefore, we examined by mutational analyses the reason for the resistance of @entity0 @entity5 , an isoform of @entity4 . We show that replacement of 10 @entity5 residues with their @entity4 counterparts effects @entity4 -like cleavability. Conversely, transfer of each of the replaced @entity5 residues to @entity4 drastically decreased the cleavability of @entity4 . By means of the existing @entity4 -toxin co-crystal structure, molecular dynamics simulations, and corroborative mutagenesis studies, the appropriate binding pockets for these residues in BoNT/A were characterized. Systematic mutagenesis of two major BoNT/A binding pockets was conducted in order to adapt these pockets to corresponding @entity2 of @entity0 @entity5 . @entity0 @entity5 cleaving mutants were isolated using a newly established @entity1 -based screening system. This method may be useful for engineering novel BoNT/A pharmaceuticals for the treatment of diseases that rely on @entity5 -mediated hypersecretion.

title: Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for @entity0 XXXX .

answer: @entity5


abstract: UNASSIGNED: Botulinum neurotoxins (BoNTs) are highly potent bacterial proteins that block neurotransmitter release at the neuromuscular junction by cleaving SNAREs (soluble @entity3 sensitive factor attachment protein receptors). However, their serotype A (BoNT/A) that cleaves @entity4 ( @entity4 ) has also been an established pharmaceutical for treatment of medical conditions that rely on hyperactivity of cholinergic nerve terminals for 25years. The expansion of its use to a variety of further medical conditions associated with hypersecretion components is prevented partly because the involved SNARE isoforms are not cleaved. Therefore, we examined by mutational analyses the reason for the resistance of @entity0 @entity5 , an isoform of @entity4 . We show that replacement of 10 @entity5 residues with their @entity4 counterparts effects @entity4 -like cleavability. Conversely, transfer of each of the replaced @entity5 residues to @entity4 drastically decreased the cleavability of @entity4 . By means of the existing @entity4 -toxin co-crystal structure, molecular dynamics simulations, and corroborative mutagenesis studies, the appropriate binding pockets for these residues in BoNT/A were characterized. Systematic mutagenesis of two major BoNT/A binding pockets was conducted in order to adapt these pockets to corresponding @entity2 of @entity0 @entity5 . @entity0 @entity5 cleaving mutants were isolated using a newly established @entity1 -based screening system. This method may be useful for engineering novel BoNT/A pharmaceuticals for the treatment of diseases that rely on @entity5 -mediated hypersecretion.

title: Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for XXXX @entity5 .

answer: @entity0


abstract: Emergency department treatment and disposition of tricyclic antidepressant ( @entity6 )- @entity4 @entity0 remains a common and difficult problem. Various clinical findings have been proposed as @entity1 indicators. To study the performance of QRS duration as a predictor of @entity1 in our @entity0 population, we retrospectively reviewed the cases of all @entity0 presenting to our @entity5 with @entity6 overdosage. The charts of 102 @entity0 with quantitative or qualitative laboratory confirmation of @entity6 ingestion were reviewed for @entity5 findings and hospital course with specific attention to the occurrence of @entity3 ( @entity3 ) or @entity2 . The @entity5 ECG revealed that 57 @entity0 had a maximal 12-lead ECG QRS interval duration (QRS) of less than .10 seconds (Group 1). The remaining 45 @entity0 had QRS greater than or equal to .10 seconds (Group 2). Three @entity0 (5%) in Group 1 and three (6%) in Group 2 experienced @entity3 . Four @entity0 (7%) in Group 1 and five (11%) in Group 2 experienced @entity2 . There was no significant difference in the rate of occurrence of @entity3 or @entity2 between the two groups. Of note was the fact that five of eight @entity3 and nine of 11 @entity2 occurred in the @entity5 setting. We conclude that determination of QRS duration is not an accurate indicator of VA or @entity2 risk for all @entity6 - @entity4 populations. In particular, risk of toxic events during the emergency phase of @entity6 @entity4 does not appear to be indicated by evaluation of the QRS duration in the @entity5 .

title: QRS interval in tricyclic antidepressant overdosage: inaccuracy as a XXXX indicator in emergency settings.

answer: @entity1


abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity7 combined with @entity4 and @entity2 for advanced @entity6 . MATERIALS AND METHODS: A total of 57 @entity0 with advanced @entity6 ( @entity6 ), who received @entity5 -based chemotherapy regimens for more than 1 cycle, were treated with @entity7 combined with @entity4 and @entity2 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity0 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity0 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity3 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity1 was foudn in 31.6% (18/57). CONCLUSIONS: @entity7 combined with @entity4 andgemcitabine, is effective for @entity0 with IIIb~IV @entity6 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with @entity7 Combined with XXXX and @entity2 for Advanced @entity6 .

answer: @entity4


abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity7 combined with @entity4 and @entity2 for advanced @entity6 . MATERIALS AND METHODS: A total of 57 @entity0 with advanced @entity6 ( @entity6 ), who received @entity5 -based chemotherapy regimens for more than 1 cycle, were treated with @entity7 combined with @entity4 and @entity2 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity0 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity0 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity3 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity1 was foudn in 31.6% (18/57). CONCLUSIONS: @entity7 combined with @entity4 andgemcitabine, is effective for @entity0 with IIIb~IV @entity6 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with @entity7 Combined with @entity4 and @entity2 for Advanced XXXX .

answer: @entity6


abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity7 combined with @entity4 and @entity2 for advanced @entity6 . MATERIALS AND METHODS: A total of 57 @entity0 with advanced @entity6 ( @entity6 ), who received @entity5 -based chemotherapy regimens for more than 1 cycle, were treated with @entity7 combined with @entity4 and @entity2 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity0 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity0 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity3 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity1 was foudn in 31.6% (18/57). CONCLUSIONS: @entity7 combined with @entity4 andgemcitabine, is effective for @entity0 with IIIb~IV @entity6 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with XXXX Combined with @entity4 and @entity2 for Advanced @entity6 .

answer: @entity7


abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity7 combined with @entity4 and @entity2 for advanced @entity6 . MATERIALS AND METHODS: A total of 57 @entity0 with advanced @entity6 ( @entity6 ), who received @entity5 -based chemotherapy regimens for more than 1 cycle, were treated with @entity7 combined with @entity4 and @entity2 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity0 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity0 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity3 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity1 was foudn in 31.6% (18/57). CONCLUSIONS: @entity7 combined with @entity4 andgemcitabine, is effective for @entity0 with IIIb~IV @entity6 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with @entity7 Combined with @entity4 and XXXX for Advanced @entity6 .

answer: @entity2


abstract: BACKGROUND: Esophagogastroduodenoscopy (EGD) is the standard technique for diagnosis of @entity0 presenting with @entity1 . Some reports have shown high prevalence of @entity2 in the northern part of Afghanistan. The aim of this study was to investigate epidemiological profile of @entity2 among @entity0 in this region. MATERIALS AND METHODS: We identified 364 consecutive @entity0 that received EGD examinations to examine upper gastrointestinal tract at the endoscopy unit of Balkh regional Hospital from March 2012 to March 2013. The case subjects included both in- @entity0 and out- @entity0 aged 16 years or more. We evaluated the results retrospectively. RESULTS: The cases consisted of 184 (51%) males and 180 (49%) females. The mean age was 47.3  17.8 and the age range 17-88 years. Ninety two cases had @entity2 , out of which 58 (63.0%) were male. The mean age at time of diagnosis was 57.8  13.2 years. Uzbek-Turkmen @entity0 were more common among @entity0 with @entity2 (52.2%). @entity3 was the most frequent symptom among @entity0 with @entity2 at the time of presentation, seen in 77 (84.8%) of cases. CONCLUSIONS: Our results showed high incidence of @entity2 in the northern part of Afghanistan, especially in the Uzbek-Turkmen ethnic group.

title: Prevalence of XXXX in the northern part of afghanistan.

answer: @entity2


abstract: OBJECTIVES: We aimed to investigate the feasibility and safety of @entity1 septal ablation (ASA) via transradial approach using a sheathless guiding catheter. BACKGROUND: Although ASA is conventionally performed via the femoral artery, there is a potential risk of @entity4 and other @entity3 . The transradial approach may be associated with a lower rate of such complications. A sheathless guiding catheter, with an advanced hydrophilic coating along its full length, could reduce radial @entity2 and @entity6 . METHODS: We enrolled 14 consecutive @entity0 with @entity5 treated with ASA via the radial access at Sendai Kousei Hospital from December 2012 to May 2014. Left radial access was used for the sheathless guiding catheter, while right radial access was used for monitoring left ventricular pressure with a 4 Fr diagnostic catheter. A temporary pacemaker was inserted via the right jugular vein. RESULTS: Procedural success rate was 93% (13/14 @entity0 ). The left ventricular outflow tract pressure gradient at rest was reduced from a median of 128 mm Hg (interquartile range, 49-147 mm Hg) at baseline to a median of 16 mm Hg (interquartile range, 13-26 mm Hg) at 30-day follow-up (P=.01). The New York Heart Association functional class improved from a median of II (II-III) at baseline to a median of I (I-I) at 30-day follow-up (P=.01). There were no cases of access-site complication, including radial @entity2 and @entity6 . CONCLUSIONS: The transradial approach using a sheathless guiding catheter was feasible and safe for ASA.

title: Transradial Approach of XXXX Septal Ablation Using a Sheathless Guiding Catheter: A Feasibility Study.

answer: @entity1


abstract: BACKGROUND:: The optimal treatment for hyperacute @entity1 attributable to cervical internal carotid artery (C-ICA) occlusion remains controversial. OBJECTIVE:: This study sought to evaluate clinical outcomes and prognostic factors after @entity4 ( @entity4 ) in @entity0 with hyperacute @entity1 within 6 hours of onset. METHODS:: Forty-seven @entity0 with hyperacute @entity1 attributable to @entity2 underwent emergent @entity4 . Forty-two @entity0 (89.4%) had @entity2 ( @entity2 ). When @entity0 showed remnant M1 or proximal M2 occlusions after @entity4 , intracranial recanalization therapy was performed by using pharmacologic thrombolysis and mechanical thrombectomy with a Solitaire stent. Clinical and radiologic data were compared between @entity0 with favorable (modified Rankin scale, 0-2) and unfavorable outcomes. Binary logistic regression analysis was used to find independent prognostic factors. RESULTS:: Emergent @entity4 was successful in all but 1 @entity0 . Seven (16.7%) of 42 @entity0 with @entity2 did not need further treatment, because thrombolysis in @entity3 >= 2b was achieved immediately after @entity4 . Of the 35 @entity0 who underwent intracranial recanalization therapy for remnant @entity2 , thrombolysis in @entity3 >= 2b was achieved in 71.4% (25 of 35). Twenty-six @entity0 (55.3%) had favorable outcomes, and mortality was 6.4% at 3 months. Time from symptom onset to carotid recanalization was inversely and independently associated with a favorable outcome for all @entity0 and for those with @entity2 (P < .05). CONCLUSION:: In our @entity0 group, emergent @entity4 for hyperacute @entity1 caused by @entity2 seemed to be effective and safe. Time to carotid recanalization was inversely and independently associated with a favorable outcome. ABBREVIATIONS:: ACST, acute carotid stent thrombosisCAS, carotid artery stentingCI, confidence intervalC-ICA, cervical internal carotid arteryCR, carotid recanalizationICH, intracranial hemorrhageIR, intracranial recanalizationIV, intravenousMCA, middle cerebral arterymRS, modified Rankin scaleNIHSS, National Institutes of Health @entity1 ScalertPA, recombinant tissue plasminogen activatorTICI, thrombolysis in cerebral ischemiaTIO, @entity2 .

title: Outcomes and Prognostic Factors After Emergent Carotid Artery Stenting for Hyperacute XXXX Within 6 Hours of Symptom Onset.

answer: @entity1


abstract: UNASSIGNED: Endometriosis is a disease characterized by the growth of endometrial tissue outside the uterus and is associated with chronic @entity6 . Peritoneal fluid (PF) of @entity0 with @entity2 is a dynamic milieu and is rich in inflammatory markers, @entity3 -inducing prostaglandins prostaglandin E2 and prostaglandin F2a, and lipid peroxides; and the endometriotic tissue is innervated with nociceptors. Our clinical study showed that the abundance of oxidatively modified lipoproteins in the PF of @entity0 with @entity2 and the ability of antioxidant supplementation to alleviate @entity3 . We hypothesized that oxidatively modified lipoproteins present in the PF are the major source of nociceptive molecules that play a key role in @entity3 . In this study, PF obtained from @entity0 with @entity2 or control @entity0 were used for (1) the detection of lipoprotein-derived oxidation-sensitive @entity3 molecules, (2) the ability of such molecules to induce nociception, and (3) the ability of antioxidants to suppress this nociception. LC-MS/MS showed the generation of eicosanoids by oxidized-lipoproteins to be similar to that seen in the PF. Oxidatively modified lipoproteins induced @entity5 (intracerebroventricular) in CD-1 @entity1 and nociception in the Hargreaves paw withdrawal latency assay in Sprague-Dawley rats. Antioxidants, vitamin E and N-acetylcysteine, and the nonsteroidal anti-inflammatory drug indomethacin suppressed the @entity3 -inducing ability of oxidatively modified lipoproteins. Treatment of @entity0 endometrial cells with oxidatively modified lipoproteins or PF from @entity0 with @entity2 showed upregulation of similar genes belonging to opioid and inflammatory pathways. Our finding that oxidatively modified lipoproteins can induce nociception has a broader impact not only on the treatment of @entity3 but also on other diseases associated with @entity4 .

title: Oxidation-sensitive nociception involved in XXXX .

answer: @entity3


abstract: UNASSIGNED: Several studies have shown that psychological factors such as learning, expectation, and emotions can affect pharmacological treatment and shape both favorable and adverse effects of drugs. This study investigated whether nocebo information provided during administration of an analgesic cream could reverse topical @entity2 to @entity3 . Furthermore, we tested whether nocebo effects were mediated by negative emotional activation. A total of 142 healthy volunteers (73 @entity0 ) were randomized into 6 groups. A topical analgesic cream (Emla) was administered together with suggestions of @entity2 in 1 group, whereas another group received Emla with suggestions of @entity3 . Two other groups received a placebo cream together with the same information as the groups receiving Emla. A fifth group received Emla with no specific information about the effect, and the sixth group received no treatment but the same @entity1 induction as the other groups. @entity1 stimulation (48  C) was administered during a pretest and 2 posttests. @entity1 was continuously recorded during stimulation, and measures of subjective stress and blood pressure were obtained before the pretest, after the application of cream, and after the posttests. The results revealed that @entity1 was significantly lower in the group receiving Emla with positive information and highest in the groups receiving suggestions of @entity3 , regardless of whether Emla or the placebo was administered. Mediation analyses showed that stress and blood pressure mediated @entity3 after nocebo suggestions. These results suggest that nocebo information can reverse topical @entity2 and that emotional factors can explain a significant proportion of variance in nocebo @entity3 .

title: Opposite effects of the same drug: reversal of topical XXXX by nocebo information.

answer: @entity2


abstract: The incidence of traumatic @entity3 are rare. In review of literature, only six cases of @entity4 in posterior fossa are reported. The @entity0 , 15-year-old @entity0 , was admitted on Dec. 18th, 1979, presented with unconsciousness after a traffic accident. She was developed @entity10 and @entity8 with @entity11 and @entity9 . Skull film showed an @entity2 and a laminal fracture of the atlas. CT scan demonstrated traumatic subarachnoid, @entity6 and @entity13 . After accident, she regained consciousness with conservative therapy, but she deteriorated on the 10th hospitalized day. On the 17th day, lumbar puncture and CT scan revealed recurrent subarachnoid and @entity6 . The @entity4 on the lateral medullary segment of the right posterior @entity12 was obtained by cerebral angiogram on the 35th day. The configuration and size of the @entity4 was easily demonstrated by CT scans and cerebral angigrams. On the 43rd day, the clipping of the common trunk of the right posterior @entity12 was employed. Her postoperative course was uneventful and she was discharged on the 97th day in @entity7 . This @entity4 was suggested to be induced by severe @entity5 with clinical ad operative findings. With the introduction of CT scan, CT scan is more available diagnostic modality than cerebral angiography in the follow up study with severe @entity5 . And in the absence of pathological CT scan findings, suspicion of traumatic @entity1 such as @entity4 should be paid. As the conservative management of traumatic @entity3 carries high mortality rate up to 30-50%, the prompt diagnosis and direct surgical intervention are recommended.

title: [Traumatic XXXX (author's transl)].

answer: @entity12


abstract: The aim of this article was to evaluate the results of relapsed @entity1 management using a simple frame construct of Ilizarov external fixator. Between 2003 and 2008, 18 feet in 13 @entity0 with relapsed @entity1 were treated by Ilizarov external fixator. All @entity0 underwent previous surgery (1-3 operations). Average @entity0 age at the time of the operation was 5.5 years and the average follow-up period was 15.8 months. Midtarsal osteotomy was undertaken in 3 feet and soft tissue distraction was undertaken in 15 feet with no soft tissue release except in 3 feet that needed tendoachillis lengthening. The average time of fixator application was 4.5 months. Out of 18 feet, 2 (11.1%) were rated as excellent, 11 (61.1%) as good, 4 (22.2%) as fair, and 1 (5.6%) as poor. Excellent and good results (72.2%) were considered satisfactory, while fair and poor results (27.8%) were considered unsatisfactory. Thus, the Ilizarov technique gave satisfactory results in cases of relapsed @entity1 that were difficult to treat by conventional methods. Longer follow-up is needed to assess the achieved correction and to detect any recurrence of the deformity.

title: The use of the Ilizarov method in management of relapsed XXXX .

answer: @entity1