abstract: PURPOSE: We examined whether bone marrow-derived dendritic cells (DCs) could induce antitumor immunity when a chemotherapeutic drug was added. METHODS: CT26 (a @entity1 @entity3 cell line syngeneic with BALB/c) and CT26-bearing @entity1 were treated with @entity4 ( @entity5 ) intraperitoneally (i.p.). Next, @entity1 immunized with a coinjection of DCs and @entity5 -treated CT26 (i.p.) were given an intradermal inoculation of CT26. Finally, CT26-bearing @entity1 were treated with @entity5 (i.p.) with or without DCs, given peritumorally. RESULTS: Although the inoculated @entity0 was not rejected in the control @entity1 , CT26 was rejected in 50% of the @entity1 injected with @entity5 alone. Apoptosis was observed in the @entity5 -treated CT26 cells in vitro and in vivo. Immunization with DCs and apoptotic CT26 cells, but not with apoptotic CT26 alone, gave protection against @entity0 challenge in 7 of 13 @entity1 . A significantly higher level of cytotoxic T-cell activity and @entity2 production was seen in the protected @entity1 . When @entity5 (i.p.) treatment was followed by peritumoral DC injection in the CT26-bearing @entity1 , remarkable therapeutic effects were observed. CONCLUSION: DCs can collaborate with chemotherapy-induced @entity0 cells and elicit improved antitumor immunity, probably through the acquisition of @entity0 -associated antigens from @entity0 cells.

title: Dendritic cells coinjected with @entity0 cells treated with an anticancer drug to induce XXXX rejection.

answer: @entity0


abstract: OBJECTIVE: Analysis of the prevalence and species representation of pathogenic @entity3 in @entity0 with @entity2 . Determination of in vitro susceptibility of @entity3 isolates to clinically used antimycotic agents. DESIGN: A retrospective clinical study of @entity0 with positive vaginal cultures for the presence of pathogenic @entity3 species. SETTING: I. gynekologicko-p  rodn  cka klinika LF UK a FN, Zochova 7,811 03 Bratislava, Slovensk   republika. METHODS: Identification of @entity3 pathogens on the chromogenic medium CHROMagar CANDIDA and with API-CANDIDA identification system. In vitro susceptibility assays of clinical @entity3 isolates to antifungal agents using the plate dilution method, NCCLS method and ATB-FUNGUS test system. RESULTS: The highest prevalence of @entity15 was found in @entity0 aged between 20-30 years. @entity8 was the most commonly identified species of pathogenic @entity3 (87.4%). Of the non-albicans species, @entity13 (6.3%) was the most prevalent species. @entity13 and C. krusei clinical isolates were found to be generally less susceptible to several antifungals in vitro as compared to @entity8 strains. A minimal number of resistant @entity3 isolates was observed for @entity9 , @entity4 and @entity14 . A relatively high number of resistant strains was observed for some other @entity10 antifungals ( @entity11 , @entity7 , @entity5 , @entity6 ). CONCLUSION: A successful treatment of @entity1 requires the results of the microbiological analyses. They will bring evidence to a physician of the presence and fate of the pathogen, of its sensitivity to antifungals, both of which are essential for the rational and successful therapy of @entity12 .

title: [ XXXX and sensitivity of pathogens to antimycotics].

answer: @entity2


abstract: The separate and combined effects of @entity5 (25 mg) and @entity2 (1 gm) on sleep were studied by interview procedures and information from medical records of 2,931 postoperative @entity0 . The sample contained 1,617 @entity0 with mild or moderate @entity1 and 1,314 who were free of @entity1 . Each received either @entity3 alone (S), @entity2 alone (A), a combination of both drugs (C), or placebo (P). Drug treatment was double blind and randomized separately for the @entity1 and @entity1 -free subsamples. Twelve measures of sleep were determined. C was more beneficial than S or A, and S and A were each superior to P. For all 12 sleep measures, the effect of the combination (C - P) approximated or exceeded the sum of the two separate effects ( @entity4 ). The presence of either drug tended to enhance the sleep benefit of the other. The sedative and analgesic benefits to sleep were at least additive, and some outcome measures suggested synergism. In the total sample, the contributions of sedative and analgesic similar. Among @entity0 with @entity1 , contributions of the analgesic surpassed those of the sedative. For @entity0 free of @entity1 , the sedative was better, but even @entity1 -free @entity0 had enhanced sleep after the analgesic. The analgesic, but not the sedative, reduced @entity1 ; the analgesic induced the feeling of being well rested and not tired; the sedative induced a feeling of being drugged. Nondrug variables (e.g., @entity1 , sex, age, and sleep expectations) influenced sleep outcome at least as much as drugs, but randomization and the large sample prevented those extraneous variables from biasing drug comparisons.

title: Effects of XXXX and @entity2 on postoperative sleep.

answer: @entity3


abstract: The separate and combined effects of @entity5 (25 mg) and @entity2 (1 gm) on sleep were studied by interview procedures and information from medical records of 2,931 postoperative @entity0 . The sample contained 1,617 @entity0 with mild or moderate @entity1 and 1,314 who were free of @entity1 . Each received either @entity3 alone (S), @entity2 alone (A), a combination of both drugs (C), or placebo (P). Drug treatment was double blind and randomized separately for the @entity1 and @entity1 -free subsamples. Twelve measures of sleep were determined. C was more beneficial than S or A, and S and A were each superior to P. For all 12 sleep measures, the effect of the combination (C - P) approximated or exceeded the sum of the two separate effects ( @entity4 ). The presence of either drug tended to enhance the sleep benefit of the other. The sedative and analgesic benefits to sleep were at least additive, and some outcome measures suggested synergism. In the total sample, the contributions of sedative and analgesic similar. Among @entity0 with @entity1 , contributions of the analgesic surpassed those of the sedative. For @entity0 free of @entity1 , the sedative was better, but even @entity1 -free @entity0 had enhanced sleep after the analgesic. The analgesic, but not the sedative, reduced @entity1 ; the analgesic induced the feeling of being well rested and not tired; the sedative induced a feeling of being drugged. Nondrug variables (e.g., @entity1 , sex, age, and sleep expectations) influenced sleep outcome at least as much as drugs, but randomization and the large sample prevented those extraneous variables from biasing drug comparisons.

title: Effects of @entity3 and XXXX on postoperative sleep.

answer: @entity2


abstract: The effect of long-term @entity4 therapy on the immune response to inactivated @entity3 vaccine was evaluated. The @entity0 were 31 white @entity0 who were receiving long-term @entity4 therapy for @entity2 disorders and 31 age-matched controls. Prevaccination blood samples were collected, and the @entity0 were vaccinated subcutaneously with 0.5-mL inactivated whole-virion trivalent @entity3 vaccine. Venous blood samples were collected at 2, 4, 6, 9, 12, and 24 weeks after vaccination and stored at -20 degrees C until analysis. Total serum @entity4 concentrations were measured by fluorescence polarization immunoassay. Immune response was measured by assaying the sera for hemagglutinin-inhibiting antibody to each of the three antigenic strains. Seroconversion was defined as a fourfold or greater increase in serum antibody titer following vaccination. In the @entity4 -treated @entity0 , the mean (+/- S.D.) serum @entity4 concentration before vaccination was 9.9 +/- 6.1 micrograms/mL. Prevaccination geometric mean titers were high enough in both groups to indicate that these @entity0 had been exposed to these or related antigens, and medical records confirmed that some of the @entity0 had been vaccinated the year before. The percent of @entity0 demonstrating seroconversion to each antigen at week 4 was low in both groups, and there were no significant differences between the two groups. The cumulative seroconversion responses observed up to week 24 were also not significantly different. Long-term @entity4 therapy should not affect the efficacy of @entity3 vaccine in @entity0 who have been previously exposed to @entity1 or vaccination with identical or related strains.

title: XXXX therapy and immune response to @entity3 vaccine.

answer: @entity4


abstract: The effect of long-term @entity4 therapy on the immune response to inactivated @entity3 vaccine was evaluated. The @entity0 were 31 white @entity0 who were receiving long-term @entity4 therapy for @entity2 disorders and 31 age-matched controls. Prevaccination blood samples were collected, and the @entity0 were vaccinated subcutaneously with 0.5-mL inactivated whole-virion trivalent @entity3 vaccine. Venous blood samples were collected at 2, 4, 6, 9, 12, and 24 weeks after vaccination and stored at -20 degrees C until analysis. Total serum @entity4 concentrations were measured by fluorescence polarization immunoassay. Immune response was measured by assaying the sera for hemagglutinin-inhibiting antibody to each of the three antigenic strains. Seroconversion was defined as a fourfold or greater increase in serum antibody titer following vaccination. In the @entity4 -treated @entity0 , the mean (+/- S.D.) serum @entity4 concentration before vaccination was 9.9 +/- 6.1 micrograms/mL. Prevaccination geometric mean titers were high enough in both groups to indicate that these @entity0 had been exposed to these or related antigens, and medical records confirmed that some of the @entity0 had been vaccinated the year before. The percent of @entity0 demonstrating seroconversion to each antigen at week 4 was low in both groups, and there were no significant differences between the two groups. The cumulative seroconversion responses observed up to week 24 were also not significantly different. Long-term @entity4 therapy should not affect the efficacy of @entity3 vaccine in @entity0 who have been previously exposed to @entity1 or vaccination with identical or related strains.

title: @entity4 therapy and immune response to XXXX vaccine.

answer: @entity3


abstract: It has been proposed that interstitial @entity4 is causally related to a progressive decrease in glomerular filtration rate (GFR), in @entity0 with various @entity1 . We examined the relationship between morphological and functional parameters in 200 samples from 74 @entity0 with @entity5 . The @entity1 was semiquantitatively analyzed using the Glomerular Index (GI). Interstitial volume (IV) was determined by the point-counting method. Both GI and IV showed a significant negative correlation with Ccr and a positive correlation with serum @entity6 . The serial change in IV from the first to the last biopsy (delta IV) showed a weak but significant negative correlation with those in Ccr, over the same period (delta Ccr). The serial change in GI (delta GI) did not correlate with delta Ccr. There was a significant positive correlation between GI and IV and between delta GI and delta IV. These data confirmed a cause-and-effect relationship between @entity2 and GFR and also showed that the @entity1 as well as the interstitial change play an important role in the deterioration of renal function. Thus, the @entity3 alone should not be emphasized as a determinant of renal function, as we noted a close correlation between the @entity1 . @entity2 is apparently secondary to the @entity1 in @entity0 with @entity5 .

title: Structural-functional correlations in serial biopsies from @entity0 with XXXX .

answer: @entity5


abstract: It has been proposed that interstitial @entity4 is causally related to a progressive decrease in glomerular filtration rate (GFR), in @entity0 with various @entity1 . We examined the relationship between morphological and functional parameters in 200 samples from 74 @entity0 with @entity5 . The @entity1 was semiquantitatively analyzed using the Glomerular Index (GI). Interstitial volume (IV) was determined by the point-counting method. Both GI and IV showed a significant negative correlation with Ccr and a positive correlation with serum @entity6 . The serial change in IV from the first to the last biopsy (delta IV) showed a weak but significant negative correlation with those in Ccr, over the same period (delta Ccr). The serial change in GI (delta GI) did not correlate with delta Ccr. There was a significant positive correlation between GI and IV and between delta GI and delta IV. These data confirmed a cause-and-effect relationship between @entity2 and GFR and also showed that the @entity1 as well as the interstitial change play an important role in the deterioration of renal function. Thus, the @entity3 alone should not be emphasized as a determinant of renal function, as we noted a close correlation between the @entity1 . @entity2 is apparently secondary to the @entity1 in @entity0 with @entity5 .

title: Structural-functional correlations in serial biopsies from XXXX with @entity5 .

answer: @entity0


abstract: In vitro and in vivo experiments were performed to evaluate the parameter of light dose rate as it relates to the efficiency of @entity4 derivative (HPD)-induced @entity5 . Exponentially growing @entity3 ovary cells were incubated with HPD (25 micrograms/ml) and were then exposed to red light (630 nm) delivered at different dose rates. A total of five dose rates (0.5, 5.0, 15, 23, and 60 milliwatts/sq cm) were examined following a 1-hr HPD incubation, two dose rates (1 and 20 milliwatts/sq cm) were examined after a 12-hr HPD incubation, and three dose rates (0.4, 4, and 40 milliwatts/sq cm) were examined following a 16-hr incubation and a 30-min serum wash protocol. The effect of light dose rate was determined from cell survival curves obtained by standard clonogenic colony formation assays. Similar levels of cellular @entity1 were obtained when cells from each HPD incubation group were treated with equal doses of red light delivered at different dose rates. For in vivo experiments, albino @entity0 were given injections of HPD (7.5 mg/kg) and 24 h later the right hind leg of each @entity0 was treated with localized red light (630 nm). A total dose of 270 J/sq cm was delivered to the right hind leg at dose rates of 5, 25, or 125 milliwatts/sq cm. The resulting acute @entity2 induced by @entity6 @entity5 was scored over a 30-day period, and skin response curves for the three dose rates were obtained. Comparable levels of damage were induced in each of the three experimental groups. The results obtained from both in vitro and in vivo studies indicate that the photosensitizing efficiency of HPD photodynamic therapy is not affected by nonthermal variations in clinically relevant dose rates of delivered light.

title: In vitro and in vivo light dose rate effects related to XXXX derivative photodynamic therapy.

answer: @entity4


abstract: The epidermal and dermal effects of protracted @entity7 ( @entity8 ) treatment (2 micrograms @entity8 twice weekly) of Sencar @entity2 skin were studied using cell kinetics and morphometric techniques. In addition, regression of @entity8 -induced changes was evaluated after cessation of 56 topical applications. During the first week of treatment a reactional @entity10 , characterized by cell damage, @entity0 , and acute @entity3 in both epidermis and dermis, occurred. This picture changed gradually during the following 3 weeks: an @entity10 devoid of involutional or inflammatory features was accompanied by a moderate to mild @entity3 of the dermis and a @entity10 of the hair follicles. This remained throughout the experimental period until the topical @entity8 treatment ceased. Although @entity8 induced @entity9 in only 5% of the animals (maximum = 2 @entity9 /animal and no @entity5 ), all sustained marked @entity10 of approximately 4 to 5 times the normal thickness, and increased the number and volume of hair follicles. The @entity6 pulse-labeling index of the basal layer was approximately 32% (normal congruent to 6%). The level of dark keratinocytes remained constant; i.e., 8% of the basal cells were identified as dark cells during the entire experiment. At the subepidermal level the dermal thickness and total cellularity increased, although the proportion of the different cell types changed during the treatment. The mast cell population increased remarkably. After @entity8 treatment ceased, most of these parameters regressed abruptly during the first 2 weeks. Two to 4 months later, the epidermis was slightly thinner, and the labeling index was 50% lower than normal (2.8%). This study shows that prolonged repetitive @entity8 applications induced a @entity10 without tachyphylaxis, and that this alteration regressed rapidly after treatment ceased. In addition, labeling-index values lower than normal were reached soon after normalization, suggesting that a possible selection of keratinocytes, dependent on @entity8 for proliferation, took place during the chronic administration of topical @entity8 . The number of hair follicle, capillary vessels, mast cells, and the dermal thickness never reached normal values after treatment. These important changes in the dermis and hair follicles indicate that the target cells for @entity1 promoters are not confined to the epidermis alone, and that these tissues could participate actively in @entity4 directly, either as @entity1 -originating tissues (hair follicles), or as inducers or helpers of @entity1 (connective tissue cells).

title: Cutaneous changes during prolonged application of XXXX on @entity2 skin and residual effects after cessation of treatment.

answer: @entity7


abstract: The epidermal and dermal effects of protracted @entity7 ( @entity8 ) treatment (2 micrograms @entity8 twice weekly) of Sencar @entity2 skin were studied using cell kinetics and morphometric techniques. In addition, regression of @entity8 -induced changes was evaluated after cessation of 56 topical applications. During the first week of treatment a reactional @entity10 , characterized by cell damage, @entity0 , and acute @entity3 in both epidermis and dermis, occurred. This picture changed gradually during the following 3 weeks: an @entity10 devoid of involutional or inflammatory features was accompanied by a moderate to mild @entity3 of the dermis and a @entity10 of the hair follicles. This remained throughout the experimental period until the topical @entity8 treatment ceased. Although @entity8 induced @entity9 in only 5% of the animals (maximum = 2 @entity9 /animal and no @entity5 ), all sustained marked @entity10 of approximately 4 to 5 times the normal thickness, and increased the number and volume of hair follicles. The @entity6 pulse-labeling index of the basal layer was approximately 32% (normal congruent to 6%). The level of dark keratinocytes remained constant; i.e., 8% of the basal cells were identified as dark cells during the entire experiment. At the subepidermal level the dermal thickness and total cellularity increased, although the proportion of the different cell types changed during the treatment. The mast cell population increased remarkably. After @entity8 treatment ceased, most of these parameters regressed abruptly during the first 2 weeks. Two to 4 months later, the epidermis was slightly thinner, and the labeling index was 50% lower than normal (2.8%). This study shows that prolonged repetitive @entity8 applications induced a @entity10 without tachyphylaxis, and that this alteration regressed rapidly after treatment ceased. In addition, labeling-index values lower than normal were reached soon after normalization, suggesting that a possible selection of keratinocytes, dependent on @entity8 for proliferation, took place during the chronic administration of topical @entity8 . The number of hair follicle, capillary vessels, mast cells, and the dermal thickness never reached normal values after treatment. These important changes in the dermis and hair follicles indicate that the target cells for @entity1 promoters are not confined to the epidermis alone, and that these tissues could participate actively in @entity4 directly, either as @entity1 -originating tissues (hair follicles), or as inducers or helpers of @entity1 (connective tissue cells).

title: Cutaneous changes during prolonged application of @entity7 on XXXX skin and residual effects after cessation of treatment.

answer: @entity2


abstract: Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic @entity2 and @entity0 . Accumulation of PSCs is a fundamental feature of pancreatic @entity2 , and platelet-derived growth factor (PDGF)-BB is the most potent mitogen for PSCs. But, the molecular mechanisms responsible for PDGF's actions in PSCs are largely unknown. In hepatic stellate cells, it has been established that activation of both @entity8 (PI) 3-kinase and @entity6 ( @entity6 ) pathways is required for PDGF-BB-induced proliferation and migration. The aim of this study was to elucidate the signaling pathways mediating PDGF-BB's actions in PSCs. PSCs were isolated from @entity1 pancreas tissue and used in their culture-activated, myofibroblast-like phenotype. Culture-activated PSCs expressed PDGF alpha- and beta-receptors. PDGF-BB induced autophosphorylation of its receptor, followed by the activation of PI 3-kinase, @entity5 , and @entity6 pathways. Activation of PI 3-kinase was not required for PDGF-BB-induced @entity6 activation. PDGF-BB induced approximately five-fold increase in proliferation and chemotaxis of PSCs. Inhibition of @entity6 pathway with @entity7 completely blocked proliferation, whereas @entity7 had a modest inhibitory effect on cell migration (approximately 50%). On the other hand, inhibition of PI 3-kinase pathway with @entity4 or @entity3 almost completely inhibited migration, but did not affect proliferation of PSCs. In conclusion, our results suggest that @entity6 pathway regulates proliferation and migration in response to PDGF-BB, whereas PI 3-kinase mediates cellular migration, but not proliferation of PSCs.

title: Differential roles of signaling pathways for proliferation and migration of XXXX pancreatic stellate cells.

answer: @entity1


abstract: AIMS AND METHODS: The aim of this health technology assessment was to analyse the current scientific and genetic counselling on predictive genetic testing for @entity0 . Predictive genetic testing will be available for several common diseases in the future and questions related to financial issues and quality standards will be raised. This report is based on a systematic/nonsystematic literature search in several databases (e.g. EmBase, Medline, Cochrane Library) and on a specific health technology assessment report (CCOHTA) and review (American Gastroenterological Ass.), respectively. Laboratory test methods, early detection methods and the benefit from prophylactic interventions were analysed and social consequences interpreted. BACKGROUND: Breast and @entity2 are counted among the most frequently @entity1 . Most of them are based on random accumulation of risk factors, 5-10% show a familial determination. A hereditary modified gene is responsible for the increased @entity1 risk. In these families, high @entity1 frequency, young age at diagnosis and multiple primary @entity1 are remarkable. RESULTS AND REFLECTION: GENETIC DIAGNOSIS: Sequence analysis is the gold standard. Denaturing high performance liquid chromatography is a quick alternative method. The identification of the responsible gene defect in an affected family member is important. If the test result is positive there is an uncertainty whether the disease will develop or not, when and in which degree, which is founded in the geno-/phenotype correlation. The individual risk estimation is based upon empirical evidence. The test results affect the whole family. PREVENTION/EARLY DETECTION: Currently, primary prevention is possible for @entity3 ( @entity6 , prophylactic colectomy) and for @entity5 (prophylactic mastectomy). The so-called preventive medical check-ups are early detection examinations. The evidence about early detection methods for @entity2 is better than for @entity0 . PROPHYLACTIC SURGICAL INTERVENTIONS: Prophylactic mastectomy (PM) reduces the relative @entity0 risk by approximately 90%. The question is if PM has an impact on mortality. The acceptance of PM is culture-dependent. Colectomy can be used as a prophylactic ( @entity4 ) and therapeutic method. After surgery, the @entity1 risk remains high and so early detection examinations are still necessary. EVIDENCE-BASED STATEMENTS: The evidence is often fragmentary and of limited quality. For objective test result presentation information about sensitivity, specificity, positive predictive value, and number needed to screen and treat, respectively, are necessary. REFLECTIONS: New identification of mutations and demand will lead to an increase of predictive genetic counselling and testing. There is a gap between predictive genetic diagnosis and prediction, prevention, early detection and surgical interventions. These circumstances require a basic strategy. Since predictive genetic diagnosis is a very sensitive issue it is important to deal with it carefully in order to avoid inappropriate hopes. Thus, media, experts and politicians need to consider opportunities and limitations in their daily decision-making processes.

title: ["Screening" in special situations. Assessing predictive genetic screening for XXXX ].

answer: @entity0


abstract: UNASSIGNED: @entity2 ( @entity2 ) is a significant risk factor for development of @entity3 in @entity0 . It is unclear, however, why some @entity0 are at an increased risk of becoming @entity3 , while others recover from the @entity2 @entity4 -free. We previously showed that the presence of a proepileptic pathology increases the risk of @entity3 in an animal model of @entity7 ( @entity7 ) after a secondary insult, which we described as the "second hit". Here we sought to evaluate the prevalence of @entity3 activity and @entity4 in @entity7 after a moderate @entity2 to determine the influence of @entity6 pathology on @entity2 -induced epileptogenesis. @entity7 was generated in @entity1 through in utero irradiation (the "first hit"). Nondysplastic and @entity7 @entity1 were surgically implanted with EEG electrodes. Craniotomies were performed over the pre-central cortex, and @entity1 were given a moderate @entity2 using the lateral fluid percussion injury device. @entity1 were monitored with chronic EEG and video. EEG data were analyzed for the occurrence of interictal spikes and @entity3 EEG @entity4 patterns. Brains were harvested and evaluated histologically. Spontaneous @entity4 are more prominent and occur earlier in @entity1 with @entity7 after a moderate @entity2 compared with nondysplastic control @entity1 . All of the @entity7 animals exhibited interictal spiking after @entity2 , while only a portion of nondysplastic animals produced spikes. These results suggest that the presence of a proepileptic pathology may increase the risk for the development of @entity3 after @entity2 . Diagnosis and treatment of @entity2 may depend on underlying pathologies contributing to @entity3 after a @entity5 .

title: Underlying @entity7 as Risk Factor for XXXX : An Animal Study.

answer: @entity3


abstract: UNASSIGNED: @entity2 ( @entity2 ) is a significant risk factor for development of @entity3 in @entity0 . It is unclear, however, why some @entity0 are at an increased risk of becoming @entity3 , while others recover from the @entity2 @entity4 -free. We previously showed that the presence of a proepileptic pathology increases the risk of @entity3 in an animal model of @entity7 ( @entity7 ) after a secondary insult, which we described as the "second hit". Here we sought to evaluate the prevalence of @entity3 activity and @entity4 in @entity7 after a moderate @entity2 to determine the influence of @entity6 pathology on @entity2 -induced epileptogenesis. @entity7 was generated in @entity1 through in utero irradiation (the "first hit"). Nondysplastic and @entity7 @entity1 were surgically implanted with EEG electrodes. Craniotomies were performed over the pre-central cortex, and @entity1 were given a moderate @entity2 using the lateral fluid percussion injury device. @entity1 were monitored with chronic EEG and video. EEG data were analyzed for the occurrence of interictal spikes and @entity3 EEG @entity4 patterns. Brains were harvested and evaluated histologically. Spontaneous @entity4 are more prominent and occur earlier in @entity1 with @entity7 after a moderate @entity2 compared with nondysplastic control @entity1 . All of the @entity7 animals exhibited interictal spiking after @entity2 , while only a portion of nondysplastic animals produced spikes. These results suggest that the presence of a proepileptic pathology may increase the risk for the development of @entity3 after @entity2 . Diagnosis and treatment of @entity2 may depend on underlying pathologies contributing to @entity3 after a @entity5 .

title: Underlying XXXX as Risk Factor for @entity3 : An Animal Study.

answer: @entity7


abstract: BACKGROUND: Normal colonic epithelial cells do not express HLA-DR antigens unless they become inflamed. It is possible that colonic epithelial cells may function as antigen-presenting cells once HLA-DR is induced by @entity1 . OBJECTIVE: The aim of this study was to investigate whether @entity2 's milk protein (CMP) is capable of inducing changes in HLA-DR expression on colonic epithelial cells, providing indirect evidence that CMP may activate cell-mediated immune mechanisms within intestinal mucosa. METHODS: HLA-DR expression was evaluated by flow cytometry on cultured @entity0 colonic epithelial cell line (HT-29) before and after treatment with bacterial lipopolysaccharide (LPS) or recombinant @entity3 ). Untreated and LPS- or @entity3 -treated HT-29 cells were then cultured in the presence of CMP. The changes in epithelial HLA-DR expression induced by CMP on untreated and LPS- or @entity3 -treated HT-29 cells were examined. RESULTS: Untreated HT-29 cells expressed very little HLA-DR molecule. Bacterial LPS or @entity3 induced a significant HLA-DR expression on HT-29 cells. When untreated HT-29 cells were cultured in the presence of CMP, there was little induction of HLA-DR expression. Culture of LPS- or @entity3 -treated HT-29 cells in the presence of CMP induced a significant increase in HLA-DR expression, which was much greater than on HT-29 cells treated with bacterial LPS or @entity3 only. CONCLUSIONS: Our results suggest that CMP initiates an immune response in the intestinal mucosa and may be responsible for the activation of cell-mediated immunity after enteric @entity1 .

title: XXXX 's milk protein induced changes in the expression of HLA-DR antigens on colonic epithelial cells.

answer: @entity2


abstract: UNASSIGNED: @entity4 and @entity1 in @entity5 are associated with adverse clinical outcomes, and appear highly related to @entity0 's @entity3 perceptions as well as with marital adjustment. This study aimed to investigate the predictive value of @entity2 variables, marital adjustment and @entity3 perceptions on @entity4 and @entity1 in @entity0 with @entity5 . Two hundred @entity0 were recruited from a @entity2 unit in a public hospital in the north of Portugal. @entity0 completed a questionnaire that assessed @entity3 perceptions (IPQ-Brief), marital adjustment (revised dyadic adjustment scale), @entity4 and @entity1 ( @entity4 scale) and @entity2 variables ( @entity2 intensity and @entity2 disability index). @entity4 and @entity1 were associated with @entity2 intensity, @entity2 , marital adjustment and @entity3 perceptions. Results from hierarchical regression showed that @entity3 perceptions contributed significantly to @entity4 and @entity1 over and above the effects of @entity2 intensity, @entity2 and marital adjustment, after controlling for gender. In multivariate analyses, @entity2 intensity, @entity2 and marital adjustment were uniquely related to @entity4 and @entity1 , whereas specific @entity3 perceptions were uniquely related to @entity4 symptoms (identity, treatment control, emotional response and coherence) and to @entity1 (identity, emotional response and concern). Perceptions of greater symptomatology (identity) and of emotional impact, and lesser perceptions of treatment control and understanding of @entity5 ( @entity3 comprehensibility) were significantly associated with increased @entity4 symptoms. Perceptions of greater symptomatology (identity), emotional impact and greater concern were associated with @entity1 . These findings indicate that the contribution of @entity3 perceptions was greater than that made by traditional covariates, and may therefore be a useful basis for future psychological interventions.

title: Illness perceptions are the main predictors of XXXX and @entity1 in @entity0 with @entity5 .

answer: @entity4


abstract: UNASSIGNED: @entity4 and @entity1 in @entity5 are associated with adverse clinical outcomes, and appear highly related to @entity0 's @entity3 perceptions as well as with marital adjustment. This study aimed to investigate the predictive value of @entity2 variables, marital adjustment and @entity3 perceptions on @entity4 and @entity1 in @entity0 with @entity5 . Two hundred @entity0 were recruited from a @entity2 unit in a public hospital in the north of Portugal. @entity0 completed a questionnaire that assessed @entity3 perceptions (IPQ-Brief), marital adjustment (revised dyadic adjustment scale), @entity4 and @entity1 ( @entity4 scale) and @entity2 variables ( @entity2 intensity and @entity2 disability index). @entity4 and @entity1 were associated with @entity2 intensity, @entity2 , marital adjustment and @entity3 perceptions. Results from hierarchical regression showed that @entity3 perceptions contributed significantly to @entity4 and @entity1 over and above the effects of @entity2 intensity, @entity2 and marital adjustment, after controlling for gender. In multivariate analyses, @entity2 intensity, @entity2 and marital adjustment were uniquely related to @entity4 and @entity1 , whereas specific @entity3 perceptions were uniquely related to @entity4 symptoms (identity, treatment control, emotional response and coherence) and to @entity1 (identity, emotional response and concern). Perceptions of greater symptomatology (identity) and of emotional impact, and lesser perceptions of treatment control and understanding of @entity5 ( @entity3 comprehensibility) were significantly associated with increased @entity4 symptoms. Perceptions of greater symptomatology (identity), emotional impact and greater concern were associated with @entity1 . These findings indicate that the contribution of @entity3 perceptions was greater than that made by traditional covariates, and may therefore be a useful basis for future psychological interventions.

title: Illness perceptions are the main predictors of @entity4 and @entity1 in @entity0 with XXXX .

answer: @entity5


abstract: UNASSIGNED: @entity4 and @entity1 in @entity5 are associated with adverse clinical outcomes, and appear highly related to @entity0 's @entity3 perceptions as well as with marital adjustment. This study aimed to investigate the predictive value of @entity2 variables, marital adjustment and @entity3 perceptions on @entity4 and @entity1 in @entity0 with @entity5 . Two hundred @entity0 were recruited from a @entity2 unit in a public hospital in the north of Portugal. @entity0 completed a questionnaire that assessed @entity3 perceptions (IPQ-Brief), marital adjustment (revised dyadic adjustment scale), @entity4 and @entity1 ( @entity4 scale) and @entity2 variables ( @entity2 intensity and @entity2 disability index). @entity4 and @entity1 were associated with @entity2 intensity, @entity2 , marital adjustment and @entity3 perceptions. Results from hierarchical regression showed that @entity3 perceptions contributed significantly to @entity4 and @entity1 over and above the effects of @entity2 intensity, @entity2 and marital adjustment, after controlling for gender. In multivariate analyses, @entity2 intensity, @entity2 and marital adjustment were uniquely related to @entity4 and @entity1 , whereas specific @entity3 perceptions were uniquely related to @entity4 symptoms (identity, treatment control, emotional response and coherence) and to @entity1 (identity, emotional response and concern). Perceptions of greater symptomatology (identity) and of emotional impact, and lesser perceptions of treatment control and understanding of @entity5 ( @entity3 comprehensibility) were significantly associated with increased @entity4 symptoms. Perceptions of greater symptomatology (identity), emotional impact and greater concern were associated with @entity1 . These findings indicate that the contribution of @entity3 perceptions was greater than that made by traditional covariates, and may therefore be a useful basis for future psychological interventions.

title: Illness perceptions are the main predictors of @entity4 and XXXX in @entity0 with @entity5 .

answer: @entity1


abstract: UNASSIGNED: @entity4 and @entity1 in @entity5 are associated with adverse clinical outcomes, and appear highly related to @entity0 's @entity3 perceptions as well as with marital adjustment. This study aimed to investigate the predictive value of @entity2 variables, marital adjustment and @entity3 perceptions on @entity4 and @entity1 in @entity0 with @entity5 . Two hundred @entity0 were recruited from a @entity2 unit in a public hospital in the north of Portugal. @entity0 completed a questionnaire that assessed @entity3 perceptions (IPQ-Brief), marital adjustment (revised dyadic adjustment scale), @entity4 and @entity1 ( @entity4 scale) and @entity2 variables ( @entity2 intensity and @entity2 disability index). @entity4 and @entity1 were associated with @entity2 intensity, @entity2 , marital adjustment and @entity3 perceptions. Results from hierarchical regression showed that @entity3 perceptions contributed significantly to @entity4 and @entity1 over and above the effects of @entity2 intensity, @entity2 and marital adjustment, after controlling for gender. In multivariate analyses, @entity2 intensity, @entity2 and marital adjustment were uniquely related to @entity4 and @entity1 , whereas specific @entity3 perceptions were uniquely related to @entity4 symptoms (identity, treatment control, emotional response and coherence) and to @entity1 (identity, emotional response and concern). Perceptions of greater symptomatology (identity) and of emotional impact, and lesser perceptions of treatment control and understanding of @entity5 ( @entity3 comprehensibility) were significantly associated with increased @entity4 symptoms. Perceptions of greater symptomatology (identity), emotional impact and greater concern were associated with @entity1 . These findings indicate that the contribution of @entity3 perceptions was greater than that made by traditional covariates, and may therefore be a useful basis for future psychological interventions.

title: Illness perceptions are the main predictors of @entity4 and @entity1 in XXXX with @entity5 .

answer: @entity0


abstract: UNASSIGNED: From 2007 to 2010, The Netherlands experienced a major @entity3 with more than 4000 notifications. Previous studies suggested that @entity3 @entity0 could suffer long-term post-infection @entity1 , especially @entity2 . Our objective was to assess the Coxiella burnetii antibody prevalence and health status including @entity2 , and assess their interrelationship in Herpen, a high-incidence village, 7 years after the outbreak began. In 2014, we invited all 2161 adult inhabitants for a questionnaire and a @entity4 indirect fluorescence antibody assay (IFA). The health status was measured with the Nijmegen Clinical Screening Instrument (NCSI), consisting of eight subdomains including @entity2 . Of the 70  1% (1517/2161) @entity0 , 33  8% (513/1517) were IFA positive. Of 147 @entity0 who were IFA positive in 2007, 25 (17%) seroreverted and were now IFA negative. Not positive IFA status, but age <50 years, smoking and co-morbidity, were independent risk factors for @entity2 . Notified @entity0 reported significantly more often @entity2 (31/49, 63%) than non-notified IFA-positive @entity0 (150/451, 33%). Although @entity2 is a common sequel after @entity3 , in this community-based survey we found no difference in @entity2 levels between @entity0 with and without C. burnetii antibodies.

title: The health status of a village population, 7 years after a major XXXX .

answer: @entity3


abstract: BACKGROUND: Information on functional outcomes after laparoscopic-assisted transanal total mesorectal excision (taTME) is limited. This study analyzed the functional results in @entity0 with @entity1 . METHODS: Ten consecutive @entity0 (nine males) undergoing electrophysiologically controlled nerve-sparing taTME were investigated prospectively and asked to complete functional questionnaires [the International Prostate Symptom Score (IPSS), International Index of Erectile Function, Female Sexual Function Index, Wexner score, and @entity3 ( @entity3 ) score]. Bladder function was also assessed according to residual urine volume. Preoperative function was compared to the functional outcome 3 and 6 months, and 9 months if eligible, after stoma closure or surgery in the absence of a diverting stoma. RESULTS: Prior to therapy, urinary and sexual function was impaired in 40 and 60% of @entity0 , respectively. None of the @entity0 developed pathological residual urine volumes after at least unilateral functional pelvic nerve-sparing. Median IPSS was lower than preoperative scores (p > 0.05). Two males with @entity2 were considered impotent during a median follow-up of 15 months (range 6-20 months). The female was judged to be sexually inactive. The median Wexner score was 1 (range 0-7) prior to any therapy and increased to 7 (range 0-15) at 6 months (p = 0.029), with 40% of @entity0 categorized as having no @entity3 and 50% minor @entity3 . The median @entity3 score was 28 (range 9-38) at 3 months and 26 (range 9-32) at 6 months (p = 0.165). CONCLUSIONS: Despite a small sample size and confounding factors, data indicate that taTME has the potential to preserve continence, sufficient bowel function, and urogenital function.

title: Midterm functional results of taTME with neuromapping for XXXX .

answer: @entity1


abstract: INTRODUCTION: The optimum mode of delivery in a known carrier of a @entity2 is still an issue of debate. AIM: This study was conducted to report a multicentre experience in Gulf Cooperation Council (GCC) on the incidence of @entity3 ( @entity3 ) in newborns with severe @entity2 delivered by different modalities. METHODS: We have conducted a retrospective/prospective multicentre cohort study including a total of seven hospitals distributed in four GCC countries between 1998 and Jan 2015. A total of 163 @entity0 with severe @entity2 (factor VIII <1%) were enrolled in this study, age ranged between 2 weeks to 18 years. RESULTS: Most of the @entity0 were born by @entity1 ( @entity1 ) (131, 80.4%), whereas 26 @entity0 (16%) were born by @entity4 and only six @entity0 were born by instrumental delivery (3.7%), five of them by vacuum and one was delivered using forceps. Five out of 163 @entity0 developed @entity3 during the first 2 weeks of life (3.1%). Two of them were born by @entity1 (2/131; 1.5%) and two were born by instrumental delivery (2/6; 33.3%). Only one @entity0 among those who were born by caesarean section developed @entity3 (1/26; 3.8%). Assisted vaginal delivery was associated with a significant risk of @entity3 , in comparison to @entity1 and @entity4 (P = 0.0093). CONCLUSION: Normal vaginal delivery is still considered a safe journey through the birth canal for haemophilic newborns particularly in this area of the world. Larger prospective studies might be needed to define an evidence-based optimal mode of delivery for the @entity2 carrier expecting an affected @entity0 .

title: Mode of delivery and risk of XXXX in newborns with severe @entity2 : a multicentre study in Gulf region.

answer: @entity3


abstract: INTRODUCTION: The optimum mode of delivery in a known carrier of a @entity2 is still an issue of debate. AIM: This study was conducted to report a multicentre experience in Gulf Cooperation Council (GCC) on the incidence of @entity3 ( @entity3 ) in newborns with severe @entity2 delivered by different modalities. METHODS: We have conducted a retrospective/prospective multicentre cohort study including a total of seven hospitals distributed in four GCC countries between 1998 and Jan 2015. A total of 163 @entity0 with severe @entity2 (factor VIII <1%) were enrolled in this study, age ranged between 2 weeks to 18 years. RESULTS: Most of the @entity0 were born by @entity1 ( @entity1 ) (131, 80.4%), whereas 26 @entity0 (16%) were born by @entity4 and only six @entity0 were born by instrumental delivery (3.7%), five of them by vacuum and one was delivered using forceps. Five out of 163 @entity0 developed @entity3 during the first 2 weeks of life (3.1%). Two of them were born by @entity1 (2/131; 1.5%) and two were born by instrumental delivery (2/6; 33.3%). Only one @entity0 among those who were born by caesarean section developed @entity3 (1/26; 3.8%). Assisted vaginal delivery was associated with a significant risk of @entity3 , in comparison to @entity1 and @entity4 (P = 0.0093). CONCLUSION: Normal vaginal delivery is still considered a safe journey through the birth canal for haemophilic newborns particularly in this area of the world. Larger prospective studies might be needed to define an evidence-based optimal mode of delivery for the @entity2 carrier expecting an affected @entity0 .

title: Mode of delivery and risk of @entity3 in newborns with severe XXXX : a multicentre study in Gulf region.

answer: @entity2


abstract: OBJECTIVES: When a partially obstructed kidney becomes infected, more rapid and extreme renal parenchymal damage appears to occur than might result from either @entity3 alone. Previously, we showed that either @entity5 or @entity8 in congenital unilateral @entity7 causes @entity0 in a @entity2 model. In this same model, we examined the combined effects of partial upper tract obstruction and @entity6 . METHODS: Female @entity2 from an inbred colony in which more than one half are born with unilateral obstructive @entity7 were studied. Type 1 piliated @entity4 was instilled into the bladder. Two to 6 days later, the @entity6 were measured during varying urinary flows (less than 2 to more than 30 mL/kg/hr). All animals were killed and the kidneys and bladder grossly and histologically assessed. @entity7 was determined at pathologic examination. RESULTS: Eight @entity2 had congenital unilateral @entity7 ; five were normal. Acute @entity1 was found in all bladder and renal specimens. In @entity0 exceeded those in nonhydronephrotic, infected kidneys at all urinary flow rates. Bladder capacity and pressures did not differ between the two groups. CONCLUSIONS: This model demonstrates that the combination of @entity3 and obstructive @entity7 in this model causes renal pelvic pressure elevation that is higher than that associated with either @entity3 or obstructive @entity7 alone. These data demonstrate the compound effect that @entity3 may have on the kidney and offers an explanation for why this clinical situation is more likely to be associated with greater renal parenchymal injury than either alone.

title: Effect of urinary tract XXXX on ureteropelvic junction obstruction in a @entity2 model.

answer: @entity3


abstract: OBJECTIVES: When a partially obstructed kidney becomes infected, more rapid and extreme renal parenchymal damage appears to occur than might result from either @entity3 alone. Previously, we showed that either @entity5 or @entity8 in congenital unilateral @entity7 causes @entity0 in a @entity2 model. In this same model, we examined the combined effects of partial upper tract obstruction and @entity6 . METHODS: Female @entity2 from an inbred colony in which more than one half are born with unilateral obstructive @entity7 were studied. Type 1 piliated @entity4 was instilled into the bladder. Two to 6 days later, the @entity6 were measured during varying urinary flows (less than 2 to more than 30 mL/kg/hr). All animals were killed and the kidneys and bladder grossly and histologically assessed. @entity7 was determined at pathologic examination. RESULTS: Eight @entity2 had congenital unilateral @entity7 ; five were normal. Acute @entity1 was found in all bladder and renal specimens. In @entity0 exceeded those in nonhydronephrotic, infected kidneys at all urinary flow rates. Bladder capacity and pressures did not differ between the two groups. CONCLUSIONS: This model demonstrates that the combination of @entity3 and obstructive @entity7 in this model causes renal pelvic pressure elevation that is higher than that associated with either @entity3 or obstructive @entity7 alone. These data demonstrate the compound effect that @entity3 may have on the kidney and offers an explanation for why this clinical situation is more likely to be associated with greater renal parenchymal injury than either alone.

title: Effect of urinary tract @entity3 on ureteropelvic junction obstruction in a XXXX model.

answer: @entity2


abstract: Antidepressant drug treatment is the clinical standard of care for all types of @entity1 . Broad efficacy of selective @entity2 reuptake inhibitors suggests the importance of enhanced serotonergic function of the anxiolytic properties of current antidepressants. However, analysis of the preclinical evidence indicates that most conventional "anxiolytic" drug tests are not sensitive to antidepressants. Such dissociation is not surprising because of the traditional approach to validation of preclinical tests that is to a large extent based on @entity4 as well as sensitivity to @entity3 anxiolytics. The present review argues for extending the cognitive model of antidepressant drug action to cover their anxiolytic properties as well. Such an approach is based on ambiguity or uncertainty in a broad sense as the hallmark of @entity0 stress that has different expressions ready for experimental modeling. These possibilities include schedule-induced behaviors that are directly based on intermittent reinforcement, conditioning to ambiguous stimuli, social stress where agonistic confrontations are possible but not predictable or controlled by the subject, and an even larger class of behaviors that are critically dependent on the inhibition of the prepotent responses in exchange for the ambiguous possibility of a later gain in reinforcement. Interestingly, in all these cases, antidepressant drug treatment is clearly effective in preclinical laboratory settings. One of the cognitive functions that appears to be affected by antidepressant drugs is inhibitory control. Inhibition of prepotent responding has beneficial effects in the "uncertainty" stress situations discussed above and therefore it is this cognitive function that may be critical for anxiolytic effects of antidepressants and novel anxiolytic drug development.

title: Antidepressant treatment in XXXX .

answer: @entity1


abstract: The term @entity3 encompasses compounds produced by the plant Cannabis sativa, such as @entity1 , and synthetic counterparts. Their actions occur mainly through activation of cannabinoid type 1 ( @entity2 ) receptors. @entity4 ( @entity4 ) and @entity5 (2-AG) serve as major endogenous ligands (endocannabinoids) of @entity2 receptors. Hence, the cannabinoid receptors, the endocannabinoids, and their metabolizing enzymes comprise the endocannabinoid system. @entity3 induce diverse responses on @entity0 - and fear-related behaviors. Generally, low doses tend to induce anxiolytic-like effects, whereas high doses often cause the opposite. Inhibition of endocannabinoid degradation seems to circumvent these biphasic effects by enhancing @entity2 receptor signaling in a temporarily and spatially restricted manner, thus reducing @entity0 -like behaviors. Pharmacological blockade or genetic deletion of @entity2 receptors, in turn, primarily exerts anxiogenic-like effects and impairments in extinction of aversive memories. Interestingly, pharmacological blockade of @entity6 ( @entity6 ) channel, which can be activated by @entity4 as well, has diametrically opposite consequences. This book chapter summarizes and conceptualizes our current knowledge about the role of (endo) @entity3 in fear and @entity0 and outlines implications for an exploitation of the endocannabinoid system as a target for new anxiolytic drugs.

title: XXXX and @entity0 .

answer: @entity3


abstract: The term @entity3 encompasses compounds produced by the plant Cannabis sativa, such as @entity1 , and synthetic counterparts. Their actions occur mainly through activation of cannabinoid type 1 ( @entity2 ) receptors. @entity4 ( @entity4 ) and @entity5 (2-AG) serve as major endogenous ligands (endocannabinoids) of @entity2 receptors. Hence, the cannabinoid receptors, the endocannabinoids, and their metabolizing enzymes comprise the endocannabinoid system. @entity3 induce diverse responses on @entity0 - and fear-related behaviors. Generally, low doses tend to induce anxiolytic-like effects, whereas high doses often cause the opposite. Inhibition of endocannabinoid degradation seems to circumvent these biphasic effects by enhancing @entity2 receptor signaling in a temporarily and spatially restricted manner, thus reducing @entity0 -like behaviors. Pharmacological blockade or genetic deletion of @entity2 receptors, in turn, primarily exerts anxiogenic-like effects and impairments in extinction of aversive memories. Interestingly, pharmacological blockade of @entity6 ( @entity6 ) channel, which can be activated by @entity4 as well, has diametrically opposite consequences. This book chapter summarizes and conceptualizes our current knowledge about the role of (endo) @entity3 in fear and @entity0 and outlines implications for an exploitation of the endocannabinoid system as a target for new anxiolytic drugs.

title: @entity3 and XXXX .

answer: @entity0


abstract: PURPOSE: We aimed to evaluate the 12-month results of a modified 360-degree suture trabeculotomy (ST) technique in @entity0 with @entity4 ( @entity4 ). @entity0 AND METHODS: The modified 360-degree ST was performed on 20 eyes of 20 consecutive @entity0 with @entity4 resistant to maximal topical treatment. In 8 @entity0 , ST was combined with phacoemulsification. The main outcome measures were the surgical success rate, the mean postoperative intraocular pressure (IOP), the number of antiglaucoma medications, and the operative complications. RESULTS: The baseline IOP (26.55  8.91) and medications (3.15  0.81) decreased significantly to 10.90  2.73 mm Hg and 0.30  0.80, respectively, at 12 months postoperatively (P<0.001). The magnitude of IOP reduction was 58.9%. Complete and qualified success rates were 68.4% and 94.7%, respectively. The entire circumference of Schlemm's canal was opened successfully in all cases. @entity3 , perforation of the trabeculodesmetic window, posterior @entity2 , peripheral anterior @entity2 , and a transient elevation of the IOP were noted. The results are comparable to our 6-month results and other previously published results for circumferential trabeculotomy. CONCLUSIONS: The modified 360-degree ST provides a feasible choice in @entity0 with @entity4 with a reasonable rate of complications. The 12-month success rates are promising. It can also be combined effectively with the current @entity1 surgery.

title: Modified 360-degree Suture Trabeculotomy for XXXX : 12-Month Results.

answer: @entity4


abstract: BACKGROUND: Purpose of this retrospective study was to analyze outcome and complications after penetrating keratoplasty (PK) in @entity0 with @entity6 . @entity0 AND METHODS: The medical records of all @entity0 with @entity6 and PK from 1985 were reviewed retrospectively. Age, sex, @entity4 , communication, indication for surgery and surgical technique, age at first PK, complications, @entity1 and best corrected @entity1 and findings at last follow-up were noted. Age matched mentally non-retarded @entity0 with @entity7 and PK served as a control group. RESULTS: All eyes of 9 @entity0 had @entity7 , 16 were operated. Indication for surgery was spontaneous perforation in 3 and refractive in the remaining 13 eyes. Five grafts were clear at last follow-up. In 7 eyes, at least 1 re-PK had to be performed. Seven eyes developed graft rejection and 4 eyes needed conjunctival grafting because of non-healing epithelial defects. Ten eyes developed @entity2 , 3 secondary @entity5 . In the control group 22 out of 25 operated corneas were clear at last follow-up. CONCLUSIONS: Prognosis of PK in @entity0 with @entity6 is worse than in other @entity0 with @entity7 . Poor results are not only explained due to the lack of cooperation of @entity0 , but also because of: 1) high rate of emergency procedures (3/16), 2) presence of lid anomalies and 3) very advanced @entity7 , necessitating bigger sized grafts, leading to frequent immunological reactions, suture loosening and secondary @entity5 . Indication for PK in @entity6 @entity0 with @entity7 and floppy eyelids should be very restrictive. @entity3 and the high rejection rate might be decreased by performing @entity8 as this would not be an intraocular procedure.

title: [Penetrating keratoplasty in XXXX ].

answer: @entity6


abstract: UNASSIGNED: Precise cell cycle control is critical for plant development and responses to pathogen invasion. Two homologous cyclin-dependent kinase inhibitor (CKI) genes, @entity4 (SIM) and SIM-RELATED 1 (SMR1), were recently shown to regulate @entity1 defense. However whether these two genes play differential roles in cell cycle and defense control is unknown. In this report, we showed that while acting synergistically to promote endoreplication, SIM and SMR1 play different roles in affecting the ploidy of trichome and leaf cells. In addition, we found that the smr1-1 mutant but not sim-1 was more susceptible to a virulent @entity2 and this susceptibility could be rescued by activating @entity3 (SA)-mediated defense. Consistent with these results, smr1-1 partially suppressed dwarfism, high SA levels, and cell death phenotypes in acd6-1, a mutant used to gauge the change of defense levels. Thus SMR1 functions partly through SA in defense control. The differential roles of SIM and SMR1 are due to differences in temporal and spatial expression of these two genes in @entity1 tissues and in response to @entity2 @entity0 . In addition flow cytometry analysis of plants with altered SA signaling revealed that SA is necessary but not sufficient to change cell cycle progression. We further found that a mutant with three CYCD3 genes disrupted also compromised disease resistance to @entity2 . Together this study reveals differential roles of two homologous CKIs in regulating cell cycle progression and innate immunity in @entity1 and provides insights into the importance of cell cycle control during host-pathogen interactions.

title: Differential Roles of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes in Regulating Cell Cycle and Innate Immunity in XXXX .

answer: @entity1


abstract: UNASSIGNED: The influence of lower limb venous compliance on orthostatic @entity3 is uncertain. The most widespread technique to calculate venous compliance uses a non-physiological quadratic regression equation. The aim was therefore to construct a physiologically derived venous wall model for calculation of @entity1 venous compliance, and to determine the effect of venous compliance on tolerance to maximal lower body negative pressure (LBNP). @entity2 plethysmography was used to study @entity1 volume changes in 15 @entity0 with @entity3 (25.5  1.3 yrs.) and 15 controls (22.8  0.8 yrs.). The fit of the venous wall model and the regression equation to the experimentally induced pressure-volume curve were examined. Venous compliance was calculated as the derivative of the modeled pressure-volume relation. Graded LBNP to presyncope was used to determine LBNP tolerance index (LTI). The venous wall model displayed a better fit to the experimentally induced pressure-volume curve (P<0.0001). @entity1 blood pooling was similar in the groups and was uncorrelated to LTI (r=0.204, P=0.30). Venous compliance was significantly reduced at low venous pressures in vasovagal @entity0 (P=0.042), and correlated to LTI (r=0.459, P=0.014) at the low pressure range. No correlation between venous compliance at high venous pressures and LTI was found. In conclusion, the new venous wall model accurately adopted the curvilinear pressure-volume curve, providing a valid characterization of venous compliance. Reduced venous compliance at low venous pressures may adversely affect mobilization of peripheral venous blood to the central circulation during hypovolemic circulatory stress in @entity0 with @entity3 .

title: Reduced venous compliance - an important determinant for orthostatic intolerance in @entity0 with XXXX .

answer: @entity3


abstract: UNASSIGNED: The influence of lower limb venous compliance on orthostatic @entity3 is uncertain. The most widespread technique to calculate venous compliance uses a non-physiological quadratic regression equation. The aim was therefore to construct a physiologically derived venous wall model for calculation of @entity1 venous compliance, and to determine the effect of venous compliance on tolerance to maximal lower body negative pressure (LBNP). @entity2 plethysmography was used to study @entity1 volume changes in 15 @entity0 with @entity3 (25.5  1.3 yrs.) and 15 controls (22.8  0.8 yrs.). The fit of the venous wall model and the regression equation to the experimentally induced pressure-volume curve were examined. Venous compliance was calculated as the derivative of the modeled pressure-volume relation. Graded LBNP to presyncope was used to determine LBNP tolerance index (LTI). The venous wall model displayed a better fit to the experimentally induced pressure-volume curve (P<0.0001). @entity1 blood pooling was similar in the groups and was uncorrelated to LTI (r=0.204, P=0.30). Venous compliance was significantly reduced at low venous pressures in vasovagal @entity0 (P=0.042), and correlated to LTI (r=0.459, P=0.014) at the low pressure range. No correlation between venous compliance at high venous pressures and LTI was found. In conclusion, the new venous wall model accurately adopted the curvilinear pressure-volume curve, providing a valid characterization of venous compliance. Reduced venous compliance at low venous pressures may adversely affect mobilization of peripheral venous blood to the central circulation during hypovolemic circulatory stress in @entity0 with @entity3 .

title: Reduced venous compliance - an important determinant for orthostatic intolerance in XXXX with @entity3 .

answer: @entity0


abstract: PURPOSE: The aim of the study was to estimate the early breakdown of the blood-aqueous barrier (BAB) following uneventful @entity2 surgery in @entity0 with @entity4 . MATERIAL AND METHODS: Aqueous flare was estimated in 54 @entity1 before and after @entity2 surgery. Fifteen eyes underwent uneventful ECCE (extracapsular @entity2 extraction with "can opener" capsulotomy) and 39 phacoemulsification with continuous curvilinear capsulorhexis. All procedures were performed by experienced surgeons. Fifty six eyes of age-matched healthy @entity0 undergoing uncomplicated @entity2 surgery served, as control. Anterior chamber flare was quantified preoperatively, 1 and 3 days postoperatively, using laser-flare meter (Kowa FM-500). Laser flare values were expressed in photon counts/millisecond. RESULTS: Mean preoperative anterior chamber flare in @entity4 was as follows: normal fundus--6.7, background @entity3 --8.6 and @entity3 --14.1 (p < 0.01 vs NF group). Significantly lower anterior chamber flare measurements following phacoemulsification (25.0-1 day, 17.8-3 days post surgery), than after ECCE (63.7 and 45.6, respectively) (p < 0.01) were observed in @entity1 . In phaco group, we noted lower flare values in eyes without @entity3 ; 25.2-1 day, 14.0-3 days post surgery, than in @entity3 (31.5 and 28.4, respectively) (p < 0.05 vs no @entity3 group). CONCLUSIONS: Phacoemulsification, as a less traumatising technique produces less BAB breakdown and seems to be more suitable than ECCE in @entity1 . Following phacoemulsification, eyes with @entity3 had significantly higher flare values than eyes without @entity3 .

title: [Anterior chamber inflammation following XXXX surgery in @entity0 with @entity4 ].

answer: @entity2


abstract: PURPOSE: The aim of the study was to estimate the early breakdown of the blood-aqueous barrier (BAB) following uneventful @entity2 surgery in @entity0 with @entity4 . MATERIAL AND METHODS: Aqueous flare was estimated in 54 @entity1 before and after @entity2 surgery. Fifteen eyes underwent uneventful ECCE (extracapsular @entity2 extraction with "can opener" capsulotomy) and 39 phacoemulsification with continuous curvilinear capsulorhexis. All procedures were performed by experienced surgeons. Fifty six eyes of age-matched healthy @entity0 undergoing uncomplicated @entity2 surgery served, as control. Anterior chamber flare was quantified preoperatively, 1 and 3 days postoperatively, using laser-flare meter (Kowa FM-500). Laser flare values were expressed in photon counts/millisecond. RESULTS: Mean preoperative anterior chamber flare in @entity4 was as follows: normal fundus--6.7, background @entity3 --8.6 and @entity3 --14.1 (p < 0.01 vs NF group). Significantly lower anterior chamber flare measurements following phacoemulsification (25.0-1 day, 17.8-3 days post surgery), than after ECCE (63.7 and 45.6, respectively) (p < 0.01) were observed in @entity1 . In phaco group, we noted lower flare values in eyes without @entity3 ; 25.2-1 day, 14.0-3 days post surgery, than in @entity3 (31.5 and 28.4, respectively) (p < 0.05 vs no @entity3 group). CONCLUSIONS: Phacoemulsification, as a less traumatising technique produces less BAB breakdown and seems to be more suitable than ECCE in @entity1 . Following phacoemulsification, eyes with @entity3 had significantly higher flare values than eyes without @entity3 .

title: [Anterior chamber inflammation following @entity2 surgery in @entity0 with XXXX ].

answer: @entity4


abstract: PURPOSE: The aim of the study was to estimate the early breakdown of the blood-aqueous barrier (BAB) following uneventful @entity2 surgery in @entity0 with @entity4 . MATERIAL AND METHODS: Aqueous flare was estimated in 54 @entity1 before and after @entity2 surgery. Fifteen eyes underwent uneventful ECCE (extracapsular @entity2 extraction with "can opener" capsulotomy) and 39 phacoemulsification with continuous curvilinear capsulorhexis. All procedures were performed by experienced surgeons. Fifty six eyes of age-matched healthy @entity0 undergoing uncomplicated @entity2 surgery served, as control. Anterior chamber flare was quantified preoperatively, 1 and 3 days postoperatively, using laser-flare meter (Kowa FM-500). Laser flare values were expressed in photon counts/millisecond. RESULTS: Mean preoperative anterior chamber flare in @entity4 was as follows: normal fundus--6.7, background @entity3 --8.6 and @entity3 --14.1 (p < 0.01 vs NF group). Significantly lower anterior chamber flare measurements following phacoemulsification (25.0-1 day, 17.8-3 days post surgery), than after ECCE (63.7 and 45.6, respectively) (p < 0.01) were observed in @entity1 . In phaco group, we noted lower flare values in eyes without @entity3 ; 25.2-1 day, 14.0-3 days post surgery, than in @entity3 (31.5 and 28.4, respectively) (p < 0.05 vs no @entity3 group). CONCLUSIONS: Phacoemulsification, as a less traumatising technique produces less BAB breakdown and seems to be more suitable than ECCE in @entity1 . Following phacoemulsification, eyes with @entity3 had significantly higher flare values than eyes without @entity3 .

title: [Anterior chamber inflammation following @entity2 surgery in XXXX with @entity4 ].

answer: @entity0


abstract: BACKGROUND: Placenta previa and @entity7 carry significant maternal and fetal morbidity and mortality. Several techniques have been described in the literature for controlling massive @entity4 associated with @entity6 cesarean sections. The objective of this study was to evaluate the efficacy and safety of the use of the cervix as a natural tamponade in controlling postpartum @entity4 caused by @entity6 and @entity6 accreta. METHODS: This prospective study was conducted on 40 pregnant @entity0 admitted to our hospital between June 2012 and November 2014. All participating @entity0 had one or more previous cesarean deliveries and were diagnosed with @entity6 and/or @entity6 accreta. Significant @entity4 from the placental bed during cesarean section was managed by inverting the cervix into the uterine cavity and suturing the anterior and/or the posterior cervical lips into the anterior and/or posterior walls of the lower uterine segment. RESULTS: The technique of cervical inversion described above was successful in stopping the @entity4 in 38 out of 40 @entity0 ; yielding a success rate of 95  %. We resorted to hysterectomy in only two cases (5  %). The mean intra-operative @entity2 was 1572.5  mL, and the mean number of blood units transfused was 3.1. The mean time needed to perform the technique was 5.4        0.6  min. The complications encountered were as follows: @entity5 in the two @entity0 who underwent hysterectomy and wound @entity3 in one @entity0 . @entity1 that responded to antibiotics occurred in 1 @entity0 . The mean duration of the postoperative hospital stay was 3.5  days CONCLUSIONS: This technique of using the cervix as a natural tamponade appears to be safe, simple, time-saving and potentially effective method for controlling the severe postpartum @entity4 (PPH) caused by @entity6 accreta. This technique deserves to be one of the tools in the hands of obstetricians who face the life-threatening @entity4 . TRIAL REGISTRATION: ClinicalTrials.gov NCT02590484 . Registered 28 October 2015.

title: The cervix as a natural tamponade in postpartum @entity4 caused by XXXX and @entity6 accreta: a prospective study.

answer: @entity6


abstract: BACKGROUND: Placenta previa and @entity7 carry significant maternal and fetal morbidity and mortality. Several techniques have been described in the literature for controlling massive @entity4 associated with @entity6 cesarean sections. The objective of this study was to evaluate the efficacy and safety of the use of the cervix as a natural tamponade in controlling postpartum @entity4 caused by @entity6 and @entity6 accreta. METHODS: This prospective study was conducted on 40 pregnant @entity0 admitted to our hospital between June 2012 and November 2014. All participating @entity0 had one or more previous cesarean deliveries and were diagnosed with @entity6 and/or @entity6 accreta. Significant @entity4 from the placental bed during cesarean section was managed by inverting the cervix into the uterine cavity and suturing the anterior and/or the posterior cervical lips into the anterior and/or posterior walls of the lower uterine segment. RESULTS: The technique of cervical inversion described above was successful in stopping the @entity4 in 38 out of 40 @entity0 ; yielding a success rate of 95  %. We resorted to hysterectomy in only two cases (5  %). The mean intra-operative @entity2 was 1572.5  mL, and the mean number of blood units transfused was 3.1. The mean time needed to perform the technique was 5.4        0.6  min. The complications encountered were as follows: @entity5 in the two @entity0 who underwent hysterectomy and wound @entity3 in one @entity0 . @entity1 that responded to antibiotics occurred in 1 @entity0 . The mean duration of the postoperative hospital stay was 3.5  days CONCLUSIONS: This technique of using the cervix as a natural tamponade appears to be safe, simple, time-saving and potentially effective method for controlling the severe postpartum @entity4 (PPH) caused by @entity6 accreta. This technique deserves to be one of the tools in the hands of obstetricians who face the life-threatening @entity4 . TRIAL REGISTRATION: ClinicalTrials.gov NCT02590484 . Registered 28 October 2015.

title: The cervix as a natural tamponade in postpartum @entity4 caused by @entity6 and XXXX accreta: a prospective study.

answer: @entity6


abstract: BACKGROUND: Placenta previa and @entity7 carry significant maternal and fetal morbidity and mortality. Several techniques have been described in the literature for controlling massive @entity4 associated with @entity6 cesarean sections. The objective of this study was to evaluate the efficacy and safety of the use of the cervix as a natural tamponade in controlling postpartum @entity4 caused by @entity6 and @entity6 accreta. METHODS: This prospective study was conducted on 40 pregnant @entity0 admitted to our hospital between June 2012 and November 2014. All participating @entity0 had one or more previous cesarean deliveries and were diagnosed with @entity6 and/or @entity6 accreta. Significant @entity4 from the placental bed during cesarean section was managed by inverting the cervix into the uterine cavity and suturing the anterior and/or the posterior cervical lips into the anterior and/or posterior walls of the lower uterine segment. RESULTS: The technique of cervical inversion described above was successful in stopping the @entity4 in 38 out of 40 @entity0 ; yielding a success rate of 95  %. We resorted to hysterectomy in only two cases (5  %). The mean intra-operative @entity2 was 1572.5  mL, and the mean number of blood units transfused was 3.1. The mean time needed to perform the technique was 5.4        0.6  min. The complications encountered were as follows: @entity5 in the two @entity0 who underwent hysterectomy and wound @entity3 in one @entity0 . @entity1 that responded to antibiotics occurred in 1 @entity0 . The mean duration of the postoperative hospital stay was 3.5  days CONCLUSIONS: This technique of using the cervix as a natural tamponade appears to be safe, simple, time-saving and potentially effective method for controlling the severe postpartum @entity4 (PPH) caused by @entity6 accreta. This technique deserves to be one of the tools in the hands of obstetricians who face the life-threatening @entity4 . TRIAL REGISTRATION: ClinicalTrials.gov NCT02590484 . Registered 28 October 2015.

title: The cervix as a natural tamponade in postpartum XXXX caused by @entity6 and @entity6 accreta: a prospective study.

answer: @entity4


abstract: The aim of this study is to examine possible antioxidant and analgesic activities of @entity6 exudes from Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe ( @entity4 ). Total antioxidant activity, reducing power, @entity0 anion radical scavenging, free radical scavenging, metal chelating, and @entity1 scavenging activities were studied. The total antioxidant activity increased with the increasing amount of extracts (100, 300, and 500 microg) added to @entity3 emulsion. All of the doses of @entity4 showed higher antioxidant activity than @entity2 . The samples showed 49, 70, and 91% inhibition on peroxidation of @entity3 emulsion, respectively. On the other hand, the 300 microg of @entity2 showed 40% inhibition on peroxidation of @entity3 emulsion. There is correlation between antioxidant activity and the reducing power, @entity0 anion radical scavenging, free radical scavenging, metal chelating, and @entity1 scavenging activities. Like antioxidant activity, the reducing power, @entity0 anion radical scavenging, free radical scavenging, metal chelating, and @entity1 scavenging activities of @entity4 depending on concentration and increasing with increased concentration of @entity4 . These properties may be the major reasons for the inhibition of lipid peroxidation. The results obtained in the present study indicate that the @entity4 has a potential source of natural antioxidant. In addition, analgesic effect of @entity4 was investigated in present study and @entity4 had strong analgesic effect. The analgesic effect of @entity4 compared with @entity5 as a standard analgesic compound.

title: Antioxidant and analgesic activities of XXXX of Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe.

answer: @entity6


abstract: OBJECTIVE: Serum levels of the soluble receptor for advanced glycation end-products (sRAGE) have been associated with risk of @entity2 . We hypothesized that sRAGE levels are associated with subclinical @entity3 in an ethnically diverse population. METHODS: Clinically @entity1 -free @entity0 in the multi-ethnic Northern Manhattan Study (NOMAS) underwent brain MRI to quantify subclinical @entity5 (SBI) and white matter hyperintensity volume (WMHV) (n = 1102). Serum levels of sRAGE were measured by ELISA. Logistic and multiple linear regression were employed to estimate associations of sRAGE with SBI and WMHV, after adjusting for demographics and vascular risk factors. RESULTS: Median sRAGE levels were significantly lower in Hispanics (891.9 pg/ml; n = 708) and @entity6 (757.4 pg/ml; n = 197) than in non-Hispanic whites (1120.5 pg/ml; n = 170), and these differences remained after adjusting for other risk factors. Interactions were observed by race-ethnicity between sRAGE levels and MRI measurements, including for SBI in Hispanics (p = 0.04) and WMHV among blacks (p = 0.03). In Hispanics, increasing sRAGE levels were associated with a lower odds of SBI, with those in the upper sRAGE quartile displaying a 50% lower odds of SBI after adjusting for sociodemographic and vascular risk factors (p = 0.05). Among blacks, those in the upper quartile of sRAGE had a similarly reduced increased risk of SBI (p = 0.06) and greater WMHV (p = 0.04). CONCLUSION: Compared to whites, Hispanics and blacks have significantly lower sRAGE levels, and these levels were associated with more subclinical @entity4 . Taken together, these findings suggest sRAGE levels may be significantly influence by ethnicity. Further studies of sRAGE and @entity1 risk, particularly in minorities, are warranted.

title: Association of serum soluble receptor for advanced glycation end-products with subclinical XXXX : the Northern Manhattan Study (NOMAS).

answer: @entity3


abstract: UNASSIGNED: The @entity5 ( @entity5 ) gene has been discussed to be associated with different symptoms of @entity1 ( @entity1 ) and other @entity2 . We aimed to elucidate the genetic association of @entity5 within @entity3 ( @entity3 ), focusing on @entity4 specific symptoms and reducing intelligence related factors. Furthermore, we compared our findings conducting a meta-analysis in @entity0 with @entity4 and @entity3 only. A case-control association study was performed for @entity3 ( @entity3 , n  =  105; controls, n  =  133). Moreover, we performed a family-based association study (DFAM) analysis ( @entity3 , n  =  44; siblings, n  =  57). Individuals were genotyped for the two most frequently reported single nucleotide polymorphisms (SNPs) in the @entity5 gene ( @entity6 , @entity7 ). Furthermore, a meta-analysis using the MIX2 software integrated our results with previously published data. A significant association for the carriers of the T-allele of the @entity7 with @entity3 was found in the case-control sample [OR  =  1.547; (95  % CI 1.056-2.266); p  =  0.025]. No association could be found by DFAM with any of the @entity5 SNPs with @entity3 . The meta-analysis of both SNPs did not show a significant association with either @entity4 or with @entity3 . Overall, including case-control, sibs, and meta-analysis, we could not detect any significant association with the @entity5 gene and @entity3 . Our results point in the direction that @entity5 may not play a major role in @entity3 , but rather seems to have a significance in @entity2 or in individuals displaying @entity2 .

title: XXXX gene in high functioning @entity4 : no association according to family and meta-analysis approaches.

answer: @entity5


abstract: UNASSIGNED: The @entity5 ( @entity5 ) gene has been discussed to be associated with different symptoms of @entity1 ( @entity1 ) and other @entity2 . We aimed to elucidate the genetic association of @entity5 within @entity3 ( @entity3 ), focusing on @entity4 specific symptoms and reducing intelligence related factors. Furthermore, we compared our findings conducting a meta-analysis in @entity0 with @entity4 and @entity3 only. A case-control association study was performed for @entity3 ( @entity3 , n  =  105; controls, n  =  133). Moreover, we performed a family-based association study (DFAM) analysis ( @entity3 , n  =  44; siblings, n  =  57). Individuals were genotyped for the two most frequently reported single nucleotide polymorphisms (SNPs) in the @entity5 gene ( @entity6 , @entity7 ). Furthermore, a meta-analysis using the MIX2 software integrated our results with previously published data. A significant association for the carriers of the T-allele of the @entity7 with @entity3 was found in the case-control sample [OR  =  1.547; (95  % CI 1.056-2.266); p  =  0.025]. No association could be found by DFAM with any of the @entity5 SNPs with @entity3 . The meta-analysis of both SNPs did not show a significant association with either @entity4 or with @entity3 . Overall, including case-control, sibs, and meta-analysis, we could not detect any significant association with the @entity5 gene and @entity3 . Our results point in the direction that @entity5 may not play a major role in @entity3 , but rather seems to have a significance in @entity2 or in individuals displaying @entity2 .

title: @entity5 gene in high functioning XXXX : no association according to family and meta-analysis approaches.

answer: @entity4


abstract: The goal of this study was to estimate the health and economic consequences of non-compliance with oral antimicrobial treatment in @entity2 with superficial @entity5 , wounds or @entity3 in the US. A mathematical model (Markov model) which simulated treatment with long-term injectable @entity6 versus oral @entity1 / @entity4 was developed and accounted for the effect of non-compliance on clinical outcomes and mean total treatment costs per @entity0 . Efficacy parameters considered in the model were derived from clinical studies. Treatment failure due to oral antimicrobial treatment non-compliance was approximated from published data at 13.6%. US cost data for 2009 were derived from public sources. When non-compliance was considered as a cause of treatment failure with oral medication, the long-term injectable antibiotic was more effective than oral comparator (162 versus 158 days without clinical signs). Mean total treatment costs were lower with @entity6 (USD 376.74) versus @entity1 / @entity4 (USD 382.34) in @entity2 of 25 kg; and @entity6 remained cost-saving up to a body weight of 31 kg. In large @entity2 , @entity6 was more costly; however, total therapy costs were less than 6% greater than with @entity1 / @entity4 . Accordingly the higher drug and administration costs of the long-term injectable antibiotic were totally or substantially offset when non-compliance was considered as reason for treatment failure with oral medication. The model also allowed for the estimation of the impact of various non-compliance scenarios.

title: Estimation of the clinical and economic consequences of non-compliance with antimicrobial treatment of XXXX skin infections.

answer: @entity2


abstract: BACKGROUND: Left ventricular (LV) ejection fraction (EF) and QRS duration enable prediction of outcome in @entity0 with @entity4 ( @entity4 ). We assessed the predictive @entity6 for prognosis in @entity4 @entity0 . METHODS AND RESULTS: Two-hundred and forty @entity4 @entity0 with LVEF  <=40% were studied. Global LV function and intraventricular @entity5 were calculated as GLS and @entity3 of the time to peak @entity6 ( @entity3  ) over 18 LV segments. The added value of GLS and @entity3   for outcome prediction was assessed using nested Cox models. Sixty-six @entity0 (28%) reached the study endpoint of all-cause mortality/heart transplantation over a median follow-up period of 45 months. Baseline variables associated with adverse outcome were age, glomerular filtration rate, pulmonary artery systolic pressure, @entity1 and LV end-systolic volume (model   (2)=69.8). The predictive power of the clinical variables was greater with addition of GLS (  (2)=81.1) or @entity3   (  (2)=102.3) than with LVEF (  (2)=73.9) or QRS duration (  (2)=75.5; both P<0.005). GLS (HR, 1.88; P=0.03) and @entity3   (HR, 1.48; P=0.04) were independent predictors after adjustment for the baseline variables. @entity0 with @entity2 (>= -7.8%) and @entity5 ( @entity3   >= 72 ms) had poor outcome. CONCLUSIONS: Combined assessment of global LV function and @entity5 using speckle-tracking strain enabled the prediction of long-term outcome in @entity4 @entity0 .

title: Combined Global Longitudinal Strain and Intraventricular Mechanical Dyssynchrony Predicts Long-Term Outcome in @entity0 With XXXX .

answer: @entity4


abstract: BACKGROUND: Left ventricular (LV) ejection fraction (EF) and QRS duration enable prediction of outcome in @entity0 with @entity4 ( @entity4 ). We assessed the predictive @entity6 for prognosis in @entity4 @entity0 . METHODS AND RESULTS: Two-hundred and forty @entity4 @entity0 with LVEF  <=40% were studied. Global LV function and intraventricular @entity5 were calculated as GLS and @entity3 of the time to peak @entity6 ( @entity3  ) over 18 LV segments. The added value of GLS and @entity3   for outcome prediction was assessed using nested Cox models. Sixty-six @entity0 (28%) reached the study endpoint of all-cause mortality/heart transplantation over a median follow-up period of 45 months. Baseline variables associated with adverse outcome were age, glomerular filtration rate, pulmonary artery systolic pressure, @entity1 and LV end-systolic volume (model   (2)=69.8). The predictive power of the clinical variables was greater with addition of GLS (  (2)=81.1) or @entity3   (  (2)=102.3) than with LVEF (  (2)=73.9) or QRS duration (  (2)=75.5; both P<0.005). GLS (HR, 1.88; P=0.03) and @entity3   (HR, 1.48; P=0.04) were independent predictors after adjustment for the baseline variables. @entity0 with @entity2 (>= -7.8%) and @entity5 ( @entity3   >= 72 ms) had poor outcome. CONCLUSIONS: Combined assessment of global LV function and @entity5 using speckle-tracking strain enabled the prediction of long-term outcome in @entity4 @entity0 .

title: Combined Global Longitudinal Strain and Intraventricular Mechanical Dyssynchrony Predicts Long-Term Outcome in XXXX With @entity4 .

answer: @entity0


abstract: From 1961 to 1984, fifty-one @entity0 with @entity1 were surgically treated at Tohoku University Hospital. The results of various types of surgical treatments for @entity1 were analysed and discussed with special reference to recurrence and the quality of life at the time of follow-up. @entity2 and @entity2 were observed in 42 and 9 @entity0 , respectively. There were five operative deaths. Thirteen @entity0 received total proctocolectomy and 38 @entity0 received various types of conservative operations at the first operation. In seven @entity0 there was a recurrence of the disease in the retained colon or rectum and proctocolectomy with ileostomy was carried out. Forty-six @entity0 were followed. Four died of other diseases and two were lost to follow-up. The periods of follow-up after the final operation ranged from 3-29 years. The types of operative procedures were ileostomy in 19, ascendicostomy in 14, @entity3 in 1 @entity0 . Following treatment of recurrence of the disease, in most @entity0 who had undergone various surgical treatments, favorable results of quality of life were attained, even in those with ileostomy. These results indicate that it is important to select the most proper types of operative procedures for surgical treatment of @entity1 by individualizing each case.

title: Long term follow-up of surgical treatment for XXXX --with special reference to recurrence and the quality of life.

answer: @entity1


abstract: A cyanotic newborn is described to illustrate and discuss the rare transient @entity4 together with functional @entity5 . Etiologically the manifold causes of perinatal @entity6 are to be taken into consideration. The clinical appearance corresponds to type A of transient @entity1 according to the classification of Rowe together with @entity2 and @entity3 . Pathogenetically the disease is based on the different histological consequences of @entity1 of the right ventricle in connection with a delayed fall of the pulmonary arterial resistance. Fetal connections lead to a pronounced right-to-left-shunt. The diagnosis is primarily established by the way of clinical and echocardiographic investigation and pulsed doppler examination. The most important differential diagnosis are in @entity8 , @entity7 and @entity5 of the right ventricular outflow tract. Therapy is conservative. Its aim is to improve myocardial performance and to lower right ventricular afterload. Outcome of @entity0 with neonatal @entity4 is uncertain and depends on the severity of @entity1 . In our @entity0 the course has been uneventful after initial difficulties.

title: [Neonatal XXXX --a contribution to the differential diagnosis of the cyanotic newborn @entity0 ].

answer: @entity4


abstract: A cyanotic newborn is described to illustrate and discuss the rare transient @entity4 together with functional @entity5 . Etiologically the manifold causes of perinatal @entity6 are to be taken into consideration. The clinical appearance corresponds to type A of transient @entity1 according to the classification of Rowe together with @entity2 and @entity3 . Pathogenetically the disease is based on the different histological consequences of @entity1 of the right ventricle in connection with a delayed fall of the pulmonary arterial resistance. Fetal connections lead to a pronounced right-to-left-shunt. The diagnosis is primarily established by the way of clinical and echocardiographic investigation and pulsed doppler examination. The most important differential diagnosis are in @entity8 , @entity7 and @entity5 of the right ventricular outflow tract. Therapy is conservative. Its aim is to improve myocardial performance and to lower right ventricular afterload. Outcome of @entity0 with neonatal @entity4 is uncertain and depends on the severity of @entity1 . In our @entity0 the course has been uneventful after initial difficulties.

title: [Neonatal @entity4 --a contribution to the differential diagnosis of the cyanotic newborn XXXX ].

answer: @entity0


abstract: BACKGROUND/AIMS: The aim of this study was to clarify long-term outcomes of endoscopic mucosal resection (EMR) using a modified Buess technique for mucosal @entity2 . METHODS: The procedure included en bloc mucosal resection using a Buess-type rectoscope into the gastric lumen via a temporary gastrostomy under video camera guidance. We reviewed 5 @entity0 who underwent this procedure between 1995 and 1997 with a single mucosal @entity1 that was unsuitable for en bloc excision by endoscopic snare diathermy. RESULTS: All @entity1 were superficial elevated types (type 0-IIa) located in the middle third and posterior wall of the stomach. Median maximum @entity1 diameter was 2.2 (range 1.1-3.5) cm. There was no operative mortality. One @entity0 developed a hemorrhagic gastric ulcer postoperatively. All @entity1 histologically showed curative potential of the mucosal resection without margin involvement. During a median follow-up period of 64 (50-77) months, none of the @entity0 developed local recurrence. One @entity0 had an @entity2 that metachronously developed at another stomach site. CONCLUSION: Intragastric EMR using a modified Buess technique appears to be a useful treatment for cure of mucosal @entity2 for a limited group of @entity0 unsuitable for complete en bloc excision by endoscopic snare diathermy.

title: Long-term outcomes of intragastric endoscopic mucosal resection using a modified buess technique for XXXX .

answer: @entity2


abstract: The @entity1 includes @entity4 , and @entity1 . The pulmonary arteries are aneurysmal and usually compress the tracheobronchial tree. These features are associated with a @entity6 and @entity7 . Nineteen @entity0 aged 5 days to 11 years were treated between 1976 and 1983. Nine were younger than 1 year. Intractable respiratory symptoms and @entity3 were the main features in the @entity0 group; five required preoperative assisted ventilation. Older @entity0 had decreased exercise tolerance and repeated @entity5 . Several surgical techniques were used in this series. The best results were achieved when the size of the main, right, and left pulmonary arteries was reduced by extensive anterior resection; the @entity6 was closed; and an aortic homograft was interposed between the right ventricle and the pulmonary artery. Four @entity0 and four @entity0 treated in this way survived the operation. Five of the nine operated @entity0 died (56%); all older @entity0 survived the operation. At follow-up, six @entity0 were asymptomatic and one was in New York Heart Association Class II. All four @entity0 were progressing satisfactorily although all had some @entity2 . Closure of the @entity6 , reduction of the size of the pulmonary arteries, and insertion of an aortic homograft was the optimal treatment in our series.

title: Surgical treatment of XXXX .

answer: @entity1


abstract: BACKGROUND: To evaluate the effect of occlusion type and fibrinolytic agent on recanalization success and clinical outcome in @entity0 undergoing local intra-arterial fibrinolysis (LIF) in acute @entity1 . METHODS: LIF was performed in 137 @entity0 with angiographically established occlusion in the carotid circulation within 6 h of @entity1 onset. Retrospective analysis included recanalization success, recanalization time, type of occlusion and fibrinolytic treatment mode. Five types of occlusion were categorized: intracranial bifurcation (carotid 'T') of the internal carotid artery (ICA; n = 35); proximal segment of the middle cerebral artery (MCA; n = 66); distal segment of the MCA (n = 20); @entity4 (n = 8); multiple peripheral branches of the anterior cerebral artery and the MCA (n = 8). Neurologic outcome was evaluated after 3 months by Barthel Index (BI) as good (BI >90), moderate (BI 50-90), poor (BI <50) or @entity2 . RESULTS: Recanalization was achieved in 74 @entity0 (54%). Mean recanalization time in recanalized @entity0 was 91 min. Neurologic outcome was good in 48 @entity0 (35%), moderate in 34 (25%), poor in 30 (22%) and 25 died (18%). Outcome was significantly better in recanalized than in nonrecanalized @entity0 (p < 0.001). Treatment results were significantly better in proximal and distal MCA occlusion than in carotid 'T' occlusions (p < 0.001). Recanalization success hardly differed between urokinase and rt-PA. Combined treatment with rt-PA and lys-plasminogen tended toward a faster recanalization. @entity3 occurred in 13 @entity0 (9%). CONCLUSION: The type of occlusion is of high prognostic value for successful fibrinolysis in the anterior circulation. However, recanalization is a time-consuming process even with an intra-arterial approach. Recanalization did not differ between type or dosage of plasminogen activators. Further innovative attempts are warranted towards hastening recanalization time in endovascular acute @entity1 treatment.

title: Local intra-arterial fibrinolysis in acute XXXX : effect of occlusion type and fibrinolytic agent on recanalization success and neurological outcome.

answer: @entity1


abstract: PURPOSE: Nonoperative treatment of serious @entity1 has been advocated and yet to our knowledge the optimum level of operative treatment has not been established to date. We report a unique data set, in which @entity0 with severe @entity1 were treated with an ultraconservative nonoperative approach during a period when urological consultation was not available at a major urban @entity2 center. MATERIALS AND METHODS: We retrospectively reviewed the charts of 51 @entity0 identified with renal @entity2 in the Detroit Receiving Hospital @entity2 data base from 1997 to 2001. RESULTS: Injuries were grades I to V in 15, 7, 11, 14 and 4 cases, respectively, and had a tendency toward @entity2 . Renorrhaphy was never performed. Nephrectomy was done sparingly, only for grade V @entity1 and only in @entity0 who were exsanguinating from the kidney. Two of the 4 @entity0 with grade V injury died of @entity5 , including massive @entity3 . Only 2 of the @entity0 treated nonoperatively (4%) had complications, including fever and @entity4 in 1 each. CONCLUSIONS: This data set seems to support an ultraconservative approach of limiting renal surgery to only @entity0 with active exsanguination. The nephrectomy rate for 14 grade IV @entity2 , including some gunshot wounds to the kidney, was 0%. When comparing this rate with that in the literature, we would expect it to be 1 @entity0 to as high as 10. This approach was safe and resulted in a low complication rate of 4%. Series in which more aggressive therapy for @entity1 is advocated should compare favorably to ultraconservative therapy if aggressive therapy is to continue to be widely advocated.

title: Effect of an institutional policy of nonoperative treatment of grades I to IV XXXX .

answer: @entity1