abstract: AIM: Athletes typically maintain rigorous training and work programs to be able to participate in competitions. An injury that occurs during the competition that causes withdrawal from the competition and a possible departure from sports, can render results athletes' and their support staff's efforts as meaningless. The early detection of @entity1 in the competition and developing preventive training programs can help ensure that participating in competitions and the associated preparatory efforts are not wasted. In this study, the @entity4 discussed occurred during training and competition events of the Turkish Shooting Sportive group. Body parts of @entity1 are determined and exercise programs focused on the affected body parts are developed. METHODS: 729 athletes (285 female, 444 male) who participated in Turkish Shooting Sports Championship during the 2010--2011 competition period participated in the study. Athletes were given a questionnaire that was developed prior to the event, and the questionnaire was filled in during interviews conducted one--on--one. Data collected from the questionnaire and the software program "SPSS 16.0" is used to analyze the results. The study was completed in six months. RESULTS: The results showed that the most of the @entity1 that occurred during training were strain and @entity0 whereas most of the @entity1 occurred during the actual competition were strain, @entity0 , @entity3 , and @entity5 . The results also indicated that during training, the most frequently--occurring @entity1 were in shoulder, @entity2 --thigh, hand and wrist; whereas during the competition, it was manifested in the shoulder, foot and ankle. CONCLUSION: Muscle strengthening, stretching and proprioception exercises for these body parts should be included as part of the athletic training program.

title: Analysis of XXXX related with shooting.

answer: @entity4


abstract: BACKGROUND: Spinning is a popular indoor stationary cycling program that uses group classes as a motivational tool. Exertional @entity6 (ER) is frequently reported in athletes and military recruits; however, infrequently it has been reported after spinning class. ER is diagnosed by clinical history, physical exam, and laboratory values. Hydration, electrolyte management, and @entity1 control are key components to treatment of this condition. Severe cases can be complicated by @entity2 , @entity4 , @entity3 , and disseminated @entity5 . PURPOSE: WE describe three cases of admission due to @entity6 after spinning. The diagnosis, admission criteria, and medical treatment of ER are presented in the context of a literature review. STUDY DESIGN: A retrospective review of three cases with review of the current literature. METHODS: The medical and laboratory records of three @entity0 cases were reviewed. A search of the PubMed database was used to perform a comprehensive review of exertional @entity6 . Our institution's IRB reviewed this study. RESULTS: We report three cases of exertional @entity6 after spinning and describe the diagnostic workup and medical management of these @entity0 . CONCLUSIONS: The diagnosis of ER is made by clinical history, physical exam, and laboratory values. The disease spectrum ranges from mild to severe with the potential of serious complications in some @entity0 . We demonstrate three cases of ER in deconditioned individuals who presented to the emergency department for evaluation. Careful medical management and @entity0 monitoring resulted in improved @entity0 symptomatology and eventual return to physical activity.

title: Exertional XXXX after spinning: case series and review of the literature.

answer: @entity6


abstract: PURPOSE: During lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to @entity4 could enhance @entity3 during resection. PROCEDURES: @entity2 with @entity1 received a contrast agent targeting @entity5 receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three @entity0 with @entity6 . RESULTS: The peak @entity1 -to-background ratio (TBR) of @entity2 @entity1 was 3.9. Fluorescence peaked at 2  h and was not improved beyond 0.1  mg/kg. Traditional inspection identified 30  % of @entity2 with positive margins. Molecular imaging identified an additional 50  % of @entity3 deposits (p   <   0.05). The fluorescent probe visually enhanced all @entity0 @entity1 with a mean TBR of 3.5. CONCLUSIONS: Molecular imaging is an important adjunct to traditional inspection to identify surgical margins after @entity1 resection.

title: Intraoperative Molecular Imaging of Lung XXXX Can Identify @entity3 Cells at the Surgical Margins.

answer: @entity4


abstract: PURPOSE: During lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to @entity4 could enhance @entity3 during resection. PROCEDURES: @entity2 with @entity1 received a contrast agent targeting @entity5 receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three @entity0 with @entity6 . RESULTS: The peak @entity1 -to-background ratio (TBR) of @entity2 @entity1 was 3.9. Fluorescence peaked at 2  h and was not improved beyond 0.1  mg/kg. Traditional inspection identified 30  % of @entity2 with positive margins. Molecular imaging identified an additional 50  % of @entity3 deposits (p   <   0.05). The fluorescent probe visually enhanced all @entity0 @entity1 with a mean TBR of 3.5. CONCLUSIONS: Molecular imaging is an important adjunct to traditional inspection to identify surgical margins after @entity1 resection.

title: Intraoperative Molecular Imaging of Lung @entity4 Can Identify XXXX Cells at the Surgical Margins.

answer: @entity3


abstract: INTRODUCTION: Interobserver variability in the definition of target volumes (TVs) is a well-known confounding factor in (multicentre) clinical studies employing radiotherapy. Therefore, detailed contouring guidelines are provided in the prospective randomised multicentre PET-Plan (NCT00697333) clinical trial protocol. This trial compares strictly FDG-PET-based TV delineation with conventional TV delineation in @entity0 with locally advanced @entity1 ( @entity1 ). Despite detailed contouring guidelines, their interpretation by different radiation oncologists can vary considerably, leading to undesirable discrepancies in TV delineation. Considering this, as part of the PET-Plan study quality assurance (QA), a contouring dummy run ( @entity2 ) consisting of two phases was performed to analyse the interobserver variability before and after teaching. MATERIALS AND METHODS: In the first phase of the @entity2 ( @entity2 ), radiation oncologists from 14 study centres were asked to delineate TVs as defined by the study protocol (gross TV, GTV; and two clinical TVs, CTV-A and CTV-B) in a test @entity0 . A teaching session was held at a study group meeting, including a discussion of the results focussing on discordances in comparison to the per-protocol solution. Subsequently, the second phase of the @entity2 ( @entity2 ) was performed in order to evaluate the impact of teaching. RESULTS: Teaching after @entity2 resulted in a reduction of absolute TVs in @entity2 , as well as in better concordance of TVs. The Overall Kappa(k) indices increased from 0.63 to 0.71 (GTV), 0.60 to 0.65 (CTV-A) and from 0.59 to 0.63 (CTV-B), demonstrating improvements in overall interobserver agreement. CONCLUSION: Contouring DRs and study group meetings as part of QA in multicentre clinical trials help to identify misinterpretations of per-protocol TV delineation. Teaching the correct interpretation of protocol contouring guidelines leads to a reduction in interobserver variability and to more consistent contouring, which should consequently improve the validity of the overall study results.

title: A teaching intervention in a contouring dummy run improved target volume delineation in locally advanced XXXX : Reducing the interobserver variability in multicentre clinical studies.

answer: @entity1


abstract: BACKGROUND: The mammary glands of @entity7 share many functional and morphological similarities with the breasts of @entity1 , raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis. Here we sought to establish a model for the efficient manipulation and transformation of porcine mammary epithelial cells (pMEC) in vitro and @entity2 growth in vivo. METHODS: We utilized a vector encoding the red florescent protein tdTomato to transduce populations of pMEC from Yorkshire -Hampshire crossbred female @entity7 in vitro and in vivo. Populations of primary pMEC were then separated by FACS using markers to distinguish epithelial cells ( @entity4 -) from stromal cells ( @entity4 +), with or without further enrichment for basal and luminal progenitor cells ( @entity9 +). These separated pMEC populations were transduced by lentivirus encoding murine polyomavirus T antigens (Tag) and tdTomato and engrafted to orthotopic or ectopic sites in immunodeficient NOD.Cg-Prkdc (scid) @entity10 (tm1Wjl) /SzJ (NSG) @entity3 . RESULTS: We demonstrated that lentivirus effectively transduces pMEC in vitro and in vivo. We further established that lentivirus can be used for oncogenic-transformation of pMEC ex vivo for generating @entity2 in vivo. Oncogenic transformation was confirmed in vitro by anchorage-independent growth, increased cell proliferation, and expression of @entity6 , @entity8 and @entity5 alongside decreased phosphorylation of Rb. Moreover, Tag-transformed @entity4 - and @entity4 - @entity9   +   pMECs developed site-specific @entity2 of differing histopathologies in vivo. CONCLUSIONS: Herein we establish a model for the transduction and oncogenic transformation of pMEC. This is the first report describing a porcine model of mammary epithelial cell tumorigenesis that can be applied to the study of @entity1 @entity0 .

title: Neoplastic transformation of porcine mammary epithelial cells in vitro and XXXX formation in vivo.

answer: @entity2


abstract: UNASSIGNED: Diagnosis of @entity2 associated myeloencephalopathy (EHM) can be troublesome, but early recognition and knowledge of risk factors are essential for prevention and control. The objectives for this study are to (1) describe EHM in France, (2) improve clinical recognition, (3) identify risk factors. Through epidemiosurveillance of acute neurological cases (all considered to be potentially infectious cases) in France (2008-2011), 26 EHM cases were identified and 29 EHM negative control cases. EHM cases were described and compared to controls with univariate, multivariate and classification and regression tree analysis. EHM cases had a 46% fatality rate and were frequently isolated cases. Most showed ataxia, paresis and a @entity1 , yet presence of other neurological signs was variable. Statistical analysis identified the following variables to be significantly associated to EHM compared to controls: introduction of a new @entity0 to the herd, @entity1 , larger herd size, saddle @entity0 and month of occurrence. The presence of many isolated cases, and less typical and variable clinical presentations emphasize the difficulty in diagnosing EHM. Nevertheless, history and clinical examination of acute neurological cases can be valuable in recognizing EHM early as well in order to select those cases that need further laboratory testing and infection control measures. Moreover, with a different study format and geographic location, risk factors were found to be similar to previous studies, therefore strengthening their significance to the spread of EHM.

title: A retrospective study on XXXX associated myeloencephalopathy in France (2008-2011).

answer: @entity2


abstract: INTRODUCTION: The knee is the most frequent location for @entity2 (60%). Until 30 years ago @entity0 with @entity2 were treated with an amputation of the affected limb; today 85% of these cases are treated with a "Limb Salvage" procedure, through replacement of the affected bone with a mega prosthesis implant. AIM: To measure functional recovery of @entity0 with a knee mega-prothesis and how rehabilitation impacts on quality of life (QOL); another aim is to define rehabilitation guidelines to manage these @entity0 in the rehabilitation pathway. METHODS: A sample of outpatients with knee mega-prosthesis were selected in the follow-up orthopedic oncology surgery between march and may 2013. We measured the functional outcome using the multidimensional standardized Musculoskeletal Tumor Society scale (MSTS) that gives a score (0-5) for each of 7 items: @entity1 , range of motion, stability, deformity, strength, functional activity, emotional acceptance. RESULTS: The sample included 28 outpatients. The median MSTS score was 29 (min 19, max 33) equal to 83%. Only 14 @entity0 (50%) followed a correct rehabilitation path after surgery. DISCUSSION: 21 cases got "excellent" outcomes and 3 "good" (based on MSTS classification). In few cases (n 4) the outcome was "fairly good", related to necessity of a prosthesis surgical revision based on instability of implant (because of usage). Quadricep strength is the item that most affects the final score. There is a statistically significant correlation between high scores and @entity0 who have recently undergone surgery. We found higher scores in @entity0 that followed a physiotherapy program after surgery: the difference was statistically significant. CONCLUSIONS: Mega-prosthesis implants give satisfactory functional outcomes. These outcomes keep high score in time. It is recommended to follow the guidelines described in the purposed rehabilitation program.

title: [Rehabilitation pathway after knee arthroplasty with mega prosthesis in XXXX ].

answer: @entity2


abstract: UNASSIGNED: There is a growing consensus that long-term deficits in the brain are due to dynamic interactions between multiple neural and immune cell types. Specifically, radiation induces an inflammatory response, including changes in neuromodulatory pro- and anti-inflammatory cytokine secretion. The purpose of this study was to establish that there is sympathetic involvement in radiation-induced decrements early in in vivo immune function host defense. Female, 8-9 week-old C57BL/6J @entity0 were exposed to whole-body irradiation (WBI). There were 8 groups with radiation (0 vs. 3Gy protons), immune challenge ( @entity1 ) and exposure to the sympathetic ganglionic blocker, @entity2 (1mg/kg weight, i.p.), as independent variables. Ten days post-irradiation, @entity0 were inoculated with @entity1 intraperitoneally and sacrificed 90-120min later. The data suggest that radiation-induced changes in immune function may in part be mediated by the sympathetic nervous system. Briefly, we found that radiation augments the bacteria-induced inflammatory cytokine response, particularly those cytokines involved in innate immunity. However, this augmentation can be reduced by the ganglionic blockade.

title: XXXX , a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge.

answer: @entity2


abstract: CONTEXT: There is limited literature on characteristics of telephone triage programs and the nature of interventions in palliative care. OBJECTIVES: Our aim was to determine frequency and type of care provided by a Supportive Care Center Telephone Triaging Program (SCCTP) in advanced @entity1 @entity0 (ACPs). METHODS: Electronic medical records were reviewed of 400 consecutive ACPs referred to palliative care at a comprehensive @entity1 center and given access to the SCCTP: 200 from the outpatient (OP) supportive care center and 200 from inpatient (IP) palliative care given access after discharge. We reviewed call frequency, type, reason, and outcomes including @entity4 and other symptoms (Edmonton Symptom Assessment Scale and Memorial Delirium Assessment Scale [MDAS]) associated with utilization of the SCCTP. RESULTS: A total of 375 @entity0 were evaluable. One hundred fifteen of 400 @entity0 (29%) used the SCCTP: 96 OPs (83%) used the SCCTP vs. only 19 IPs (17%) (P  <  0.001). The most common reasons for calls were @entity4 (24%), @entity4 medication refills (24%), and counseling (12%). For 115 phone calls, 43% (145 of 340) of recommendations were regarding care at home and 56% were regarding opioids. @entity0 who used the SCCTP had worse @entity4 (P  =  0.006), @entity6 (P  =  0.045), @entity5 (P  =  0.041), and well-being (P  =  0.015) and better MDAS scores (P  =  0.014) compared with nonusers. OPs had a higher prevalence of symptom distress (P  =  0.013), @entity5 (P  <  0.001), @entity3 (P  <  0.01), and @entity2 scores (P  =  0.001); MDAS scores were significantly higher in IPs (P  <  0.001). CONCLUSION: In this study, we found that overall utilization of the SCCTP by ACPs referred to palliative care was relatively low at 28.7%. The use of the SCCTP was particularly poor among the IPs on discharge. @entity0 who used SCCTP had worse @entity4 , @entity6 , @entity5 , and well-being scores and better delirium scores.

title: The Frequency and Factors Associated With the Use of a Dedicated Supportive Care Center Telephone Triaging Program in @entity0 With @entity1 at a XXXX Center.

answer: @entity1


abstract: CONTEXT: There is limited literature on characteristics of telephone triage programs and the nature of interventions in palliative care. OBJECTIVES: Our aim was to determine frequency and type of care provided by a Supportive Care Center Telephone Triaging Program (SCCTP) in advanced @entity1 @entity0 (ACPs). METHODS: Electronic medical records were reviewed of 400 consecutive ACPs referred to palliative care at a comprehensive @entity1 center and given access to the SCCTP: 200 from the outpatient (OP) supportive care center and 200 from inpatient (IP) palliative care given access after discharge. We reviewed call frequency, type, reason, and outcomes including @entity4 and other symptoms (Edmonton Symptom Assessment Scale and Memorial Delirium Assessment Scale [MDAS]) associated with utilization of the SCCTP. RESULTS: A total of 375 @entity0 were evaluable. One hundred fifteen of 400 @entity0 (29%) used the SCCTP: 96 OPs (83%) used the SCCTP vs. only 19 IPs (17%) (P  <  0.001). The most common reasons for calls were @entity4 (24%), @entity4 medication refills (24%), and counseling (12%). For 115 phone calls, 43% (145 of 340) of recommendations were regarding care at home and 56% were regarding opioids. @entity0 who used the SCCTP had worse @entity4 (P  =  0.006), @entity6 (P  =  0.045), @entity5 (P  =  0.041), and well-being (P  =  0.015) and better MDAS scores (P  =  0.014) compared with nonusers. OPs had a higher prevalence of symptom distress (P  =  0.013), @entity5 (P  <  0.001), @entity3 (P  <  0.01), and @entity2 scores (P  =  0.001); MDAS scores were significantly higher in IPs (P  <  0.001). CONCLUSION: In this study, we found that overall utilization of the SCCTP by ACPs referred to palliative care was relatively low at 28.7%. The use of the SCCTP was particularly poor among the IPs on discharge. @entity0 who used SCCTP had worse @entity4 , @entity6 , @entity5 , and well-being scores and better delirium scores.

title: The Frequency and Factors Associated With the Use of a Dedicated Supportive Care Center Telephone Triaging Program in @entity0 With XXXX at a @entity1 Center.

answer: @entity1


abstract: CONTEXT: There is limited literature on characteristics of telephone triage programs and the nature of interventions in palliative care. OBJECTIVES: Our aim was to determine frequency and type of care provided by a Supportive Care Center Telephone Triaging Program (SCCTP) in advanced @entity1 @entity0 (ACPs). METHODS: Electronic medical records were reviewed of 400 consecutive ACPs referred to palliative care at a comprehensive @entity1 center and given access to the SCCTP: 200 from the outpatient (OP) supportive care center and 200 from inpatient (IP) palliative care given access after discharge. We reviewed call frequency, type, reason, and outcomes including @entity4 and other symptoms (Edmonton Symptom Assessment Scale and Memorial Delirium Assessment Scale [MDAS]) associated with utilization of the SCCTP. RESULTS: A total of 375 @entity0 were evaluable. One hundred fifteen of 400 @entity0 (29%) used the SCCTP: 96 OPs (83%) used the SCCTP vs. only 19 IPs (17%) (P  <  0.001). The most common reasons for calls were @entity4 (24%), @entity4 medication refills (24%), and counseling (12%). For 115 phone calls, 43% (145 of 340) of recommendations were regarding care at home and 56% were regarding opioids. @entity0 who used the SCCTP had worse @entity4 (P  =  0.006), @entity6 (P  =  0.045), @entity5 (P  =  0.041), and well-being (P  =  0.015) and better MDAS scores (P  =  0.014) compared with nonusers. OPs had a higher prevalence of symptom distress (P  =  0.013), @entity5 (P  <  0.001), @entity3 (P  <  0.01), and @entity2 scores (P  =  0.001); MDAS scores were significantly higher in IPs (P  <  0.001). CONCLUSION: In this study, we found that overall utilization of the SCCTP by ACPs referred to palliative care was relatively low at 28.7%. The use of the SCCTP was particularly poor among the IPs on discharge. @entity0 who used SCCTP had worse @entity4 , @entity6 , @entity5 , and well-being scores and better delirium scores.

title: The Frequency and Factors Associated With the Use of a Dedicated Supportive Care Center Telephone Triaging Program in XXXX With @entity1 at a @entity1 Center.

answer: @entity0


abstract: UNASSIGNED: Reported @entity3 prevalence varies widely, with an estimated prevalence of 0.2% in the general population. Sensitization to fish can occur by ingestion, skin contact or inhalation. The manifestations can be IgE or non-IgE mediated. Several fish allergens have been identified, with parvalbumins being the major allergen in various species. Allergenicity varies among fish species and is affected by processing or preparation methods. Adverse reactions after eating fish are often claimed to be ' @entity2 ' but could be a reaction to hidden food allergen, fish parasite, fish toxins or @entity1 in spoiled fish. Identifying such causes would allow free consumption of fish. Correct diagnosis of @entity3 , including the specific species, might provide the @entity0 with safe alternatives. @entity0 have been generally advised for strict universal avoidance of fish. However, testing with various fish species or preparations might identify one or more forms that can be tolerated.

title: Fish-allergic XXXX may be able to eat fish.

answer: @entity0


abstract: UNASSIGNED: Molecular genetics now plays a crucial role in diagnosis, the identification of prognostic markers, and monitoring of @entity2 . Demonstration of acquired changes such as the @entity3 @entity4 mutation within @entity1 ( @entity1 ) has quickly moved from a research setting to the diagnostic laboratory. Microfluidics-based assays can reduce the assay time and sample/reagent consumption and enhance the reaction efficiency; however, no current assay has integrated isothermal amplification for point-of-care @entity1 @entity3 @entity4 mutation testing with a microchip. In this report, an integrated microchip that performs the whole @entity0 blood genomic DNA extraction, loop-mediated isothermal nucleic acid amplification (LAMP) and visual detection for point-of-care genetic mutation testing is demonstrated. This method was validated on DNA from cell lines as well as on whole blood from @entity0 with @entity1 . The results were compared with those obtained by unlabeled probe melting curve analysis. This chip enjoys a high accuracy, operability, and cost/time efficiency within 1h. All these benefits provide the chip with a potency toward a point-of-care genetic analysis. All samples identified as positive by unlabeled probe melting curve analysis (n=27) proved positive when tested by microchip assay. None of the 30 negative controls gave false positive results. In addition, a @entity0 with @entity5 vera diagnosed as being @entity3 @entity4 -negative by unlabeled probe melting curve analysis was found to be positive by the microchip. This microchip would possibly be very attractive in developing a point-of-care platform for quick preliminary diagnosis of @entity1 or other severe illness in resource-limited settings.

title: Toward point-of-care testing for XXXX @entity4 mutation on a microchip.

answer: @entity3


abstract: UNASSIGNED: Molecular genetics now plays a crucial role in diagnosis, the identification of prognostic markers, and monitoring of @entity2 . Demonstration of acquired changes such as the @entity3 @entity4 mutation within @entity1 ( @entity1 ) has quickly moved from a research setting to the diagnostic laboratory. Microfluidics-based assays can reduce the assay time and sample/reagent consumption and enhance the reaction efficiency; however, no current assay has integrated isothermal amplification for point-of-care @entity1 @entity3 @entity4 mutation testing with a microchip. In this report, an integrated microchip that performs the whole @entity0 blood genomic DNA extraction, loop-mediated isothermal nucleic acid amplification (LAMP) and visual detection for point-of-care genetic mutation testing is demonstrated. This method was validated on DNA from cell lines as well as on whole blood from @entity0 with @entity1 . The results were compared with those obtained by unlabeled probe melting curve analysis. This chip enjoys a high accuracy, operability, and cost/time efficiency within 1h. All these benefits provide the chip with a potency toward a point-of-care genetic analysis. All samples identified as positive by unlabeled probe melting curve analysis (n=27) proved positive when tested by microchip assay. None of the 30 negative controls gave false positive results. In addition, a @entity0 with @entity5 vera diagnosed as being @entity3 @entity4 -negative by unlabeled probe melting curve analysis was found to be positive by the microchip. This microchip would possibly be very attractive in developing a point-of-care platform for quick preliminary diagnosis of @entity1 or other severe illness in resource-limited settings.

title: Toward point-of-care testing for @entity3 XXXX mutation on a microchip.

answer: @entity4


abstract: UNASSIGNED: Episodic @entity5 represents an important and underappreciated clinical feature in pediatric @entity4 . This study examined the incidence and clinical correlates of @entity5 in @entity0 with @entity4 . Change in @entity5 during treatment for @entity4 was also examined. @entity0 consisted of 107 @entity0 diagnosed with an @entity4 and their parents. @entity0 completed structured clinical interviews and questionnaire measures to assess @entity5 , @entity2 , family accommodation and caregiver strain, as well as the quality of the @entity0 's relationship with family and peers. @entity5 was a common feature amongst @entity0 with @entity4 . @entity5 was associated with a more severe clinical profile, including increased @entity4 severity, functional impairment, family accommodation and caregiver strain, as well as poorer relationships with parents, siblings, extended family and peers. @entity5 was more common in @entity0 with separation @entity4 , comorbid @entity4 , @entity1 and @entity3 , but not depressive symptoms. @entity5 predicted higher levels of functional impairment, beyond the effect of @entity4 severity. @entity5 severity reduced over treatment in line with changes in @entity4 . Findings suggest that @entity5 is a marker of greater psychopathology in anxious youth. Standard cognitive behavioral treatment for @entity4 appears to reduce @entity5 without adjunctive treatment.

title: Incidence, clinical correlates and treatment effect of XXXX in anxious @entity0 .

answer: @entity5


abstract: UNASSIGNED: Episodic @entity5 represents an important and underappreciated clinical feature in pediatric @entity4 . This study examined the incidence and clinical correlates of @entity5 in @entity0 with @entity4 . Change in @entity5 during treatment for @entity4 was also examined. @entity0 consisted of 107 @entity0 diagnosed with an @entity4 and their parents. @entity0 completed structured clinical interviews and questionnaire measures to assess @entity5 , @entity2 , family accommodation and caregiver strain, as well as the quality of the @entity0 's relationship with family and peers. @entity5 was a common feature amongst @entity0 with @entity4 . @entity5 was associated with a more severe clinical profile, including increased @entity4 severity, functional impairment, family accommodation and caregiver strain, as well as poorer relationships with parents, siblings, extended family and peers. @entity5 was more common in @entity0 with separation @entity4 , comorbid @entity4 , @entity1 and @entity3 , but not depressive symptoms. @entity5 predicted higher levels of functional impairment, beyond the effect of @entity4 severity. @entity5 severity reduced over treatment in line with changes in @entity4 . Findings suggest that @entity5 is a marker of greater psychopathology in anxious youth. Standard cognitive behavioral treatment for @entity4 appears to reduce @entity5 without adjunctive treatment.

title: Incidence, clinical correlates and treatment effect of @entity5 in anxious XXXX .

answer: @entity0


abstract: BACKGROUND AND PURPOSE: The aim of the study was to determine the effectiveness of @entity4 for treatment of compressive @entity3 . MATERIALS AND METHODS: A retrospective analysis was conducted on 24 @entity0 with 58 symptomatic @entity3 treated by balloon kyphoplasty. Visual Analogue @entity2 Scale (VAS) and @entity5 Index (ODI) were used to assess @entity3 -related @entity2 and @entity0 's disability: preoperatively and within 12-months follow-up. Following the procedures to evaluate the change of @entity1 , the angle of local @entity6 was measured. RESULTS: Preoperative VAS score was 6.54, at discharge it significantly regressed in 95.8% of @entity0 . The overall VAS score at discharge was 1.25 and within 12 months decreased to 0.26. Preoperative ODI score was 50%, at follows-up in all @entity0 it decreased, ranging from 21% to 10%. Reduction of local @entity6 was achieved in 30 (51.7%) vertebrae by average 4.3  . In 9 (37.5%) @entity0 @entity6 of all augmented vertebrae was reduced, in 7 (29.2%) @entity0 procedures reduced @entity6 in part of augmented vertebrae and in 8 @entity0 (33.3%) @entity6 remained unchanged. Asymptomatic complications included cement leak in 10 (17%) vertebrae and intraoperative rupture of 4 (4%) balloons. CONCLUSIONS: Rapid significant @entity2 relief after kyphoplasty followed by long-term @entity2 release and disability reduction obtained in all @entity0 was most probably the result of @entity7 . The correction of local @entity6 had no influence on the outcome.

title: @entity4 in the treatment of painful vertebral compression fractures: Effect on local XXXX and one-year outcomes in @entity2 and disability.

answer: @entity6


abstract: BACKGROUND AND PURPOSE: The aim of the study was to determine the effectiveness of @entity4 for treatment of compressive @entity3 . MATERIALS AND METHODS: A retrospective analysis was conducted on 24 @entity0 with 58 symptomatic @entity3 treated by balloon kyphoplasty. Visual Analogue @entity2 Scale (VAS) and @entity5 Index (ODI) were used to assess @entity3 -related @entity2 and @entity0 's disability: preoperatively and within 12-months follow-up. Following the procedures to evaluate the change of @entity1 , the angle of local @entity6 was measured. RESULTS: Preoperative VAS score was 6.54, at discharge it significantly regressed in 95.8% of @entity0 . The overall VAS score at discharge was 1.25 and within 12 months decreased to 0.26. Preoperative ODI score was 50%, at follows-up in all @entity0 it decreased, ranging from 21% to 10%. Reduction of local @entity6 was achieved in 30 (51.7%) vertebrae by average 4.3  . In 9 (37.5%) @entity0 @entity6 of all augmented vertebrae was reduced, in 7 (29.2%) @entity0 procedures reduced @entity6 in part of augmented vertebrae and in 8 @entity0 (33.3%) @entity6 remained unchanged. Asymptomatic complications included cement leak in 10 (17%) vertebrae and intraoperative rupture of 4 (4%) balloons. CONCLUSIONS: Rapid significant @entity2 relief after kyphoplasty followed by long-term @entity2 release and disability reduction obtained in all @entity0 was most probably the result of @entity7 . The correction of local @entity6 had no influence on the outcome.

title: XXXX in the treatment of painful vertebral compression fractures: Effect on local @entity6 and one-year outcomes in @entity2 and disability.

answer: @entity4


abstract: BACKGROUND AND PURPOSE: The aim of the study was to determine the effectiveness of @entity4 for treatment of compressive @entity3 . MATERIALS AND METHODS: A retrospective analysis was conducted on 24 @entity0 with 58 symptomatic @entity3 treated by balloon kyphoplasty. Visual Analogue @entity2 Scale (VAS) and @entity5 Index (ODI) were used to assess @entity3 -related @entity2 and @entity0 's disability: preoperatively and within 12-months follow-up. Following the procedures to evaluate the change of @entity1 , the angle of local @entity6 was measured. RESULTS: Preoperative VAS score was 6.54, at discharge it significantly regressed in 95.8% of @entity0 . The overall VAS score at discharge was 1.25 and within 12 months decreased to 0.26. Preoperative ODI score was 50%, at follows-up in all @entity0 it decreased, ranging from 21% to 10%. Reduction of local @entity6 was achieved in 30 (51.7%) vertebrae by average 4.3  . In 9 (37.5%) @entity0 @entity6 of all augmented vertebrae was reduced, in 7 (29.2%) @entity0 procedures reduced @entity6 in part of augmented vertebrae and in 8 @entity0 (33.3%) @entity6 remained unchanged. Asymptomatic complications included cement leak in 10 (17%) vertebrae and intraoperative rupture of 4 (4%) balloons. CONCLUSIONS: Rapid significant @entity2 relief after kyphoplasty followed by long-term @entity2 release and disability reduction obtained in all @entity0 was most probably the result of @entity7 . The correction of local @entity6 had no influence on the outcome.

title: @entity4 in the treatment of painful vertebral compression fractures: Effect on local @entity6 and one-year outcomes in XXXX and disability.

answer: @entity2


abstract: BACKGROUND: The study aimed at estimating the effect of body mass index (BMI), used to classify @entity1 , @entity1 , and morbidly @entity1 @entity0 , on clinical outcomes in total laparoscopic hysterectomy (TLH) cases. METHODS: This retrospective cohort study included 153 @entity0 who underwent TLH for benign, premalignant, or malignant conditions between August 2010 and June 2013. @entity0 were divided into 3 groups according to BMI, and the following variables were analyzed: operation time, conversion rate, @entity2 , total complications, and length of hospital stay. RESULTS: The mean BMI was 33.5 kg/m(2) (range, 22-61). Forty-four @entity0 were @entity1 (BMI <30), 73 were @entity1 (30 <= BMI <40), and 36 were morbidly @entity1 (BMI >= 40). In 138 @entity0 (90.2%), hysterectomy was performed using an endoscopic technique. The rate of conversion to laparotomy (9.8%; 95% confidence interval (CI), 5.1-14.5), @entity2 (70.5 ml; range, 10-700), total complications (5.9%), and length of hospital stay (2.9 d; range, 1-8) did not vary according to BMI. Operation time was longer in @entity1 (p = 0.003) and morbidly @entity1 (0.002) @entity0 than in @entity1 @entity0 . CONCLUSION: TLH could be considered a safe and feasible alternative to abdominal hysterectomy in @entity1 and morbidly @entity1 @entity0 .    2015 S. Karger AG, Basel.

title: Total Laparoscopic Hysterectomy in Obese and Morbidly Obese XXXX .

answer: @entity0


abstract: AIM: To assess the clinical features and outcome of @entity3 when associated with @entity2 and to determine whether this association gives @entity3 a better prognosis. DESIGN: Multicentre retrospective cohort study. METHODS: Retrospective chart review. RESULTS: Twenty-one @entity0 were included (9 males, 12 females). Median age at @entity2 diagnosis was 48 years (range: 24-68 years). In 14 cases, @entity3 occurred within a previously known @entity2 . Five @entity0 received a concomitant diagnosis of @entity2 and @entity3 , whereas @entity3 preceded @entity2 in two @entity0 . Three @entity0 were diagnosed with @entity5 and 18 @entity0 with @entity8 ( @entity7 ( @entity7 ) (n = 11), @entity3 (n = 2), @entity6 /small @entity6 (n = 2), anaplastic large cell @entity3 ALK + (n = 1), angioimmunoblastic @entity4 (n = 1) and @entity9 (n = 1)). Thirteen @entity0 were alive and in complete remission. Median age at the time of diagnosis of @entity2 was lower in @entity0 with @entity3 compared with @entity0 with @entity2 preceding @entity3 (34 years vs. 51 years, P = 0.01). @entity0 presenting with @entity7 associated with @entity2 were compared with @entity7 without @entity2 . No statistical difference was found in the risk of @entity1 or progression between the two groups (P = 0.685). CONCLUSIONS: We report here the largest series of @entity3 associated @entity2 @entity0 . As opposed to previous studies, we observed a predominance of @entity0 with @entity7 . Our study confirms the concept of the @entity3 . Large @entity7 does not have a better prognosis when associated with @entity2 .

title: XXXX and @entity3 : a comparative study.

answer: @entity2


abstract: AIM: To assess the clinical features and outcome of @entity3 when associated with @entity2 and to determine whether this association gives @entity3 a better prognosis. DESIGN: Multicentre retrospective cohort study. METHODS: Retrospective chart review. RESULTS: Twenty-one @entity0 were included (9 males, 12 females). Median age at @entity2 diagnosis was 48 years (range: 24-68 years). In 14 cases, @entity3 occurred within a previously known @entity2 . Five @entity0 received a concomitant diagnosis of @entity2 and @entity3 , whereas @entity3 preceded @entity2 in two @entity0 . Three @entity0 were diagnosed with @entity5 and 18 @entity0 with @entity8 ( @entity7 ( @entity7 ) (n = 11), @entity3 (n = 2), @entity6 /small @entity6 (n = 2), anaplastic large cell @entity3 ALK + (n = 1), angioimmunoblastic @entity4 (n = 1) and @entity9 (n = 1)). Thirteen @entity0 were alive and in complete remission. Median age at the time of diagnosis of @entity2 was lower in @entity0 with @entity3 compared with @entity0 with @entity2 preceding @entity3 (34 years vs. 51 years, P = 0.01). @entity0 presenting with @entity7 associated with @entity2 were compared with @entity7 without @entity2 . No statistical difference was found in the risk of @entity1 or progression between the two groups (P = 0.685). CONCLUSIONS: We report here the largest series of @entity3 associated @entity2 @entity0 . As opposed to previous studies, we observed a predominance of @entity0 with @entity7 . Our study confirms the concept of the @entity3 . Large @entity7 does not have a better prognosis when associated with @entity2 .

title: @entity2 and XXXX : a comparative study.

answer: @entity3


abstract: BACKGROUND AND PURPOSE: Aneurysm progression and @entity1 is thought to be governed by progressive degradation and weakening of the wall in response to abnormal hemodynamics. Our goal was to investigate the relationship between the intra-aneurysmal hemodynamic conditions and wall mechanical properties in @entity0 @entity3 . MATERIALS AND METHODS: A total of 8 unruptured @entity3 were analyzed. Computational fluid dynamics models were constructed from preoperative 3D rotational angiography images. The @entity3 were clipped, and the domes were resected and mechanically tested to failure with a uniaxial testing system under multiphoton microscopy. Linear regression analysis was performed to explore possible correlations between hemodynamic quantities and the failure characteristics and stiffness of the wall. RESULTS: The ultimate strain was correlated negatively to @entity3 rate (P = .021), mean velocity (P = .025), and mean wall shear stress (P = .039). It was also correlated negatively to inflow concentration, oscillatory shear index, and measures of the complexity and instability of the flow; however, these trends did not reach statistical significance. The wall stiffness at high strains was correlated positively to inflow rate (P = .014), mean velocity (P = .008), inflow concentration (P = .04), flow instability (P = .006), flow complexity (P = .019), wall shear stress (P = .002), and oscillatory shear index (P = .004). CONCLUSIONS: In a study of 8 unruptured @entity2 , ultimate strain was correlated negatively with @entity3 rate, mean velocity, and mean wall shear stress. Wall stiffness was correlated positively with @entity3 rate, mean velocity, wall shear stress, flow complexity and stability, and oscillatory shear index. These trends and the impact of hemodynamics on wall structure and mechanical properties should be investigated further in larger studies.

title: Wall Mechanical Properties and Hemodynamics of Unruptured XXXX .

answer: @entity2


abstract: DNA analysis can reveal the origins and dispersal patterns of invasive species. The @entity2 @entity2 is one such alien animal, which has been dispersed widely by @entity0 from its native North America to many Pacific Ocean islands. In the Ogasawara (Bonin) Islands, this anole was recorded from Chichi-jima at the end of the 1960s, and then from Haha-jima in the early 1980s. These two islands are inhabited. In 2013, it was also found on the uninhabited Ani-jima, close to Chichi-jima. @entity0 are thought to have introduced the anole to Haha-jima, while the mode of introduction to Ani-jima is unknown. To clarify its dispersal patterns within and among these three islands, we assessed the fine-scale population genetic structure using five microsatellite loci. The results show a homogeneous genetic structure within islands, but different @entity1 among islands, suggesting that limited gene flow occurs between islands. The recently established Ani-jima population may have originated from several individuals simultaneously, or by repeated immigration from Chichi-jima. We must consider frequent incursions among these islands to control these invasive lizard populations and prevent their negative impact on native biodiversity.

title: Microsatellite Analysis of the Population Genetic Structure of XXXX Introduced to the Ogasawara Islands.

answer: @entity2


abstract: OBJECTIVES: The purpose of this study was to evaluate the usefulness of MRI-guidance for core decompression of @entity4 of the @entity5 . MATERIALS AND METHODS: Twelve MRI-guided core decompressions were performed on @entity0 with different stages of @entity4 of the @entity5 . The @entity0 were asked to evaluate their @entity2 and their ability to function before and after the procedure and imaging findings were reviewed respectively. RESULTS: Technical success in reaching the target was 100  % without complications. Mean duration of the procedure itself was 54  min. All @entity0 with ARCO stage 1 @entity4 experienced clinical benefit and pathological MRI findings were seen to diminish. @entity0 with more @entity3 gained less, if any, benefit and total hip arthroplasty was eventually performed on four @entity0 . CONCLUSIONS: MRI-guidance seems technically feasible, accurate and safe for core decompression of @entity4 of the @entity5 . @entity0 with early stage @entity4 may benefit from the procedure. KEY POINTS:     MRI is a useful guidance method for minimally invasive musculoskeletal interventions.     Bone drilling seems beneficial at early stages of @entity4 .     MRI-guidance is safe and accurate for @entity1 .

title: MRI-guidance in percutaneous core decompression of @entity4 of the XXXX .

answer: @entity5


abstract: OBJECTIVES: The purpose of this study was to evaluate the usefulness of MRI-guidance for core decompression of @entity4 of the @entity5 . MATERIALS AND METHODS: Twelve MRI-guided core decompressions were performed on @entity0 with different stages of @entity4 of the @entity5 . The @entity0 were asked to evaluate their @entity2 and their ability to function before and after the procedure and imaging findings were reviewed respectively. RESULTS: Technical success in reaching the target was 100  % without complications. Mean duration of the procedure itself was 54  min. All @entity0 with ARCO stage 1 @entity4 experienced clinical benefit and pathological MRI findings were seen to diminish. @entity0 with more @entity3 gained less, if any, benefit and total hip arthroplasty was eventually performed on four @entity0 . CONCLUSIONS: MRI-guidance seems technically feasible, accurate and safe for core decompression of @entity4 of the @entity5 . @entity0 with early stage @entity4 may benefit from the procedure. KEY POINTS:     MRI is a useful guidance method for minimally invasive musculoskeletal interventions.     Bone drilling seems beneficial at early stages of @entity4 .     MRI-guidance is safe and accurate for @entity1 .

title: MRI-guidance in percutaneous core decompression of XXXX of the @entity5 .

answer: @entity4


abstract: BACKGROUND AND PURPOSE: Mid-size sphincterotomy associated with @entity1 is an alternative to wide @entity2 . However, which of the two techniques is most effective remains unclear. Hence, we conducted this study to compare both methods prospectively. METHOD: Since January 2012 until March 2014, 133 consecutive @entity0 with complex stones were included. Group A underwent mid-size sphincterotomy associated with @entity1 and group B underwent wide sphincterotomy alone. Success rates were assessed for: Extraction of stones, ductal patency rate, the use of mechanical lithotripsy, dose, time and dose per radioscopy area as well as procedure-related complications. RESULTS: Group A comprised 44 @entity0 and group B comprised 69 @entity0 . Overall success rate for extraction was 86.4% in group A and 70% in group B (p = 0.069). In @entity2 , effective extraction was 89.3% in group A and 58.6% in group B (p = 0.019). Use of mechanical lithotripsy was 15.9% and 30.4%, respectively (p = 0.142). Total radiotherapy dose was 39.8 mGy vs. 26.2 mGy, respectively (p = 0.134). Complications occurred in 6.8% and 5.5% of the procedures in each group, without significant differences among them (p = 0.856). CONCLUSION: @entity1 is more effective and equally safe than conventional sphincterotomy for the management of giant main bile duct lithiasis.

title: XXXX versus sphincterotomy alone for the extraction of complex lithiasis: A prospective analysis.

answer: @entity1


abstract: BACKGROUND: Severe or prolonged stress can trigger @entity1 illnesses including mood and @entity2 . Recent work indicates that @entity3 plays an important role in regulating stress effects. In rodents, exogenous @entity3 administration can produce persistent elevations in the acoustic startle response, which may reflect @entity2 -like signs including hypervigilance. We investigated whether @entity3 causes acute or persistent alterations in behaviors that reflect other core features of mood and @entity2 (motivation, social interaction, and attention). METHODS: Using male @entity0 , we examined if @entity3 (.25-1.0   g, intracerebroventricular infusion) affects motivation as measured in the intracranial self-stimulation test. We also examined if @entity3 alters interactions with a conspecific in the social interaction test. Finally, we examined if @entity3 affects performance in the 5-choice serial reaction time task, which quantifies attention and error processing. RESULTS: Dose-dependent disruptions in motivation, social interaction, and attention were produced by @entity3 , as reflected by increases in reward thresholds, decreases in social behaviors, and decreases in correct responses and alterations in posterror accuracy. Behavior normalized quickly in the intracranial self-stimulation and 5-choice serial reaction time task tests but remained dysregulated in the social interaction test. Effects on attention were attenuated by the corticotropin-releasing factor receptor-1 antagonist @entity4 but not the k opioid receptor antagonist JDTic. CONCLUSIONS: Our findings suggest that @entity3 affects numerous domains often dysregulated in mood and @entity2 , but that individual signs depend on brain substrates that are at least partially independent. This work may help to devise therapeutics that mitigate specific signs of these disorders.

title: Pituitary Adenylate Cyclase-Activating Polypeptide Disrupts Motivation, Social Interaction, and Attention in Male XXXX .

answer: @entity0


abstract: BACKGROUND: Sickle cell (SC) disease leading to @entity14 induces skeletal changes in the form of @entity12 , @entity6 of femoral canal and @entity8 of the femoral head. All these make @entity3 ( @entity3 ) difficult and prolonged. There is increased risk of @entity2 , SC crisis and increased complication rate. Our paper aims to highlight preoperative, intraoperative and postoperative hurdles encountered in performing @entity3 in sicklers and the short term outcome using cementless implants. MATERIALS AND METHODS: Thirty-nine @entity0 with @entity10 , who had @entity8 of the femoral head, were operated between 2007 and 2011. The mean age of @entity0 was 22 years (range 13-49 years). There were twenty eight females and 11 males. @entity3 (THR) was performed in 11 @entity0 (22 hips) and in the rest unilateral (28 hips). Preoperative and postoperative modified Harris hip score was evaluated. The average followup was 3.8 years (range 2-6 years). RESULTS: The average operating time was 96 min (range 88-148 min). The average @entity1 was 880 ml (range 650-1200 ml). The average intraoperative blood transfused was 2.3 units (range 2-5 units). All @entity0 showed an improvement in Harris hip score from 42 points preoperatively to 92 points at latest followup. Intraoperatively, one @entity0 had a @entity11 . Six @entity0 developed @entity13 and were managed in intensive care unit. Three @entity0 developed wound @entity5 . Three @entity0 developed limb length discrepancy less than 1 cm. None had early or late dislocations, @entity2 , @entity9 , @entity7 and @entity4 . CONCLUSION: @entity3 in sicklers involves considerable challenge for the orthopedic surgeon. Management requires a multidisciplinary approach involving the anesthetist, hematologist and the orthopedic surgeon. Contrary to previous reports, @entity3 in sicklers now has a predictable outcome especially with the use of cementless implants.

title: Short term results of XXXX in sicklers.

answer: @entity3


abstract: PURPOSE: Long-term outcomes of @entity0 with T1 @entity2 ( @entity2 ) treated by endoscopic resection (ER) or surgical resection are unclear in relation to the curative criteria in the Japanese Society for @entity3 (JSCCR) guidelines. The aim of this study was to retrospectively compare the long-term outcomes among @entity0 with T1 @entity2 in relation to the treatment methods. METHODS: We examined 322 T1 @entity2 cases treated between January 1992 and August 2008 at Hiroshima University Hospital. @entity0 who did not meet the curative criteria in the JSCCR guidelines were defined as "non-endoscopically curable" and classified into three groups: underwent ER alone (group A: 45 @entity0 ), underwent additional surgery after ER (group B: 106 @entity0 ), and underwent surgical resection alone (group C: 92 @entity0 ). RESULTS: Of the 322 T1 @entity2 @entity0 , 79 were categorized as endoscopically curable and 243 as non-endoscopically curable. Among the endoscopically curable T1 @entity2 @entity0 , recurrence and 5-year @entity4 rates were 0 and 94.2  %, respectively. In groups A, B, and C, recurrence rates were 4.4, 6.6, and 4.3  %, and @entity4 rates were 85.6, 95.1, and 96.3  %, respectively (p   <   0.05). Local recurrence or distant/lymph node @entity1 was observed in 13 @entity0 (group A: 2; group B: 7; group C: 4). Death due to primary @entity2 occurred in six @entity0 (group B: 4; group C: 2). CONCLUSION: Long-term outcomes support the curative criteria according to the JSCCR guidelines. ER for T1 @entity2 did not worsen clinical outcomes in cases that required additional surgical resection.

title: Long-term outcomes after treatment for T1 XXXX .

answer: @entity2


abstract: Fluorescein angiography was performed in 71 @entity0 at risk to develop Leber's @entity2 (L.O.N.), in 10 females carriers of this disease and in 5 @entity0 during the acute phase. The examination was performed in three university eye clinics. The angiograms were randomly mixed with an equal number of 'controls' and reviewed in a blind fashion on two occasions by two observers. A scoring system was developed on the basis of the peripapillary microvascular changes known to occur in the acute phase of L.O.N. All 5 @entity0 could be recognised in this manner. In the pictures of one of the clinics, which were of good quality, a significant difference in scoring between the at risk and control groups appeared to exist. The results suggest that carriers also may have the same @entity1 angiographic abnormalities. One @entity0 from the at risk group who obtained high abnormal scores-identical to @entity0 in the acute phase-developed L.O.N. 6 months later.

title: Leber's XXXX II. @entity1 angiographic studies.

answer: @entity2


abstract: Fluorescein angiography was performed in 71 @entity0 at risk to develop Leber's @entity2 (L.O.N.), in 10 females carriers of this disease and in 5 @entity0 during the acute phase. The examination was performed in three university eye clinics. The angiograms were randomly mixed with an equal number of 'controls' and reviewed in a blind fashion on two occasions by two observers. A scoring system was developed on the basis of the peripapillary microvascular changes known to occur in the acute phase of L.O.N. All 5 @entity0 could be recognised in this manner. In the pictures of one of the clinics, which were of good quality, a significant difference in scoring between the at risk and control groups appeared to exist. The results suggest that carriers also may have the same @entity1 angiographic abnormalities. One @entity0 from the at risk group who obtained high abnormal scores-identical to @entity0 in the acute phase-developed L.O.N. 6 months later.

title: Leber's @entity2 II. XXXX angiographic studies.

answer: @entity1


abstract: AIM: The aim was to report the effectiveness and safety @entity6 (Botox, Allergan, Inc., Irvine, CA, USA) intradetrusor injections in spinal cord-injured (SCI) @entity0 with refractory neurogenic detrusor overactivity. And to assess the result based on SCI level. MATERIALS AND METHODS: We reviewed the chart of 103 @entity0 with @entity4 secondary to SCI at the rehab center who received @entity6 in our Neurourology Department for treatment of lower urinary tract symptoms between January 2007 and December 2013. All @entity0 had a clinical examination, urinalysis, and an urodynamic study at baseline and 3 months after treatment as well as a visual analogue scale (VAS; range scale: 0-10) and a bladder diary checked for 3 days. 300 IU of @entity6 , detrusor muscle injections were performed in 30 sites under cystoscopic guidance. Outcome measures included frequency of urge urinary @entity2 collected by bladder diaries; changes in urodynamic parameters such as maximum cystometric bladder capacity, reflex volume, maximum detrusor pressure; side-effects; antimuscarinic drug consumption and quality of life (QOL) measured with VAS. RESULTS: The study includes 32 female and 71 male with a mean @entity0 age of 29 years (range: 18-56 year). The effect of Botox injection on bladder function was observed within 1-2 week after treatment. The urodynamic parameters were improved significantly after treatment compared with baseline values. There were significant reductions in the frequencies of @entity2 episodes after treatment as seen in the voiding diary. A significant improvement in @entity0 satisfaction was found after treatment which was expressed on the VAS assessment, with an improvement of the mean of 3 points. @entity0 with @entity3 have better result compare to @entity1 @entity0 . The earliest recurrence of clinical symptoms was at 10 weeks. Overall, the mean duration of symptomatic improvement was 8 (2.5-21) months. CONCLUSION: Intradetrusor @entity6 injections are an effective and well-tolerated treatment for @entity5 that will increase @entity0 satisfaction and improve QOL with persisted clinical efficacy for more than 8 months.

title: The effect of spinal cord-injury level on the outcome of XXXX treatment using @entity6 .

answer: @entity4


abstract: AIM: The aim was to report the effectiveness and safety @entity6 (Botox, Allergan, Inc., Irvine, CA, USA) intradetrusor injections in spinal cord-injured (SCI) @entity0 with refractory neurogenic detrusor overactivity. And to assess the result based on SCI level. MATERIALS AND METHODS: We reviewed the chart of 103 @entity0 with @entity4 secondary to SCI at the rehab center who received @entity6 in our Neurourology Department for treatment of lower urinary tract symptoms between January 2007 and December 2013. All @entity0 had a clinical examination, urinalysis, and an urodynamic study at baseline and 3 months after treatment as well as a visual analogue scale (VAS; range scale: 0-10) and a bladder diary checked for 3 days. 300 IU of @entity6 , detrusor muscle injections were performed in 30 sites under cystoscopic guidance. Outcome measures included frequency of urge urinary @entity2 collected by bladder diaries; changes in urodynamic parameters such as maximum cystometric bladder capacity, reflex volume, maximum detrusor pressure; side-effects; antimuscarinic drug consumption and quality of life (QOL) measured with VAS. RESULTS: The study includes 32 female and 71 male with a mean @entity0 age of 29 years (range: 18-56 year). The effect of Botox injection on bladder function was observed within 1-2 week after treatment. The urodynamic parameters were improved significantly after treatment compared with baseline values. There were significant reductions in the frequencies of @entity2 episodes after treatment as seen in the voiding diary. A significant improvement in @entity0 satisfaction was found after treatment which was expressed on the VAS assessment, with an improvement of the mean of 3 points. @entity0 with @entity3 have better result compare to @entity1 @entity0 . The earliest recurrence of clinical symptoms was at 10 weeks. Overall, the mean duration of symptomatic improvement was 8 (2.5-21) months. CONCLUSION: Intradetrusor @entity6 injections are an effective and well-tolerated treatment for @entity5 that will increase @entity0 satisfaction and improve QOL with persisted clinical efficacy for more than 8 months.

title: The effect of spinal cord-injury level on the outcome of @entity4 treatment using XXXX .

answer: @entity6


abstract: Cancers can be addicted to continued and relatively high expression of nuclear oncoproteins. This is evident in @entity1 ( @entity1 ) where the oncoprotein and transcription factor @entity7 is over expressed and essential to continued proliferation and @entity0 cell survival. Historically, targeting transcription factors in the context of @entity0 has been very challenging. Nevertheless, we formulated a DNA vaccine to generate a @entity7 -specific immune response in the belief @entity7 peptides might be aberrantly presented on the cell surface of @entity1 cells. @entity7 , like many @entity0 antigens, is weakly immunogenic as it is a 'self' antigen and is subject to tolerance. To break tolerance, a fusion vaccine was generated comprising a full-length @entity7 complementary DNA (cDNA) flanked by two potent @entity6 -epitopes derived from @entity3 toxoid. Vaccination was achieved against @entity0 initiated by two distinct highly aggressive, syngeneic @entity0 cell lines (CT26 and MC38) that express @entity7 . This was done in BALB/c and C57BL/6 @entity2 strains respectively. We introduced multiple inactivating mutations into the oncogene sequence for safety and sub-cloned the cDNA into a Food and Drug Administration (FDA)-compliant vector. We used low dose @entity4 (CY) to overcome T-regulatory cell immune suppression, and anti-program cell death receptor 1 (anti- @entity5 ) antibodies to block T-cell exhaustion. Anti-PD-1 administered alone slightly delayed @entity0 growth in MC38 and more effectively in CT26 bearing @entity2 , while CY treatment alone did not. We found that therapeutic vaccination elicits protection when MC38 @entity0 burden is low, mounts @entity0 -specific cell killing and affords enhanced protection when MC38 and CT26 @entity0 burden is higher but only in combination with anti-PD-1 antibody or low dose CY, respectively.

title: Therapeutic DNA vaccination against @entity1 by targeting the XXXX oncoprotein.

answer: @entity7


abstract: Cancers can be addicted to continued and relatively high expression of nuclear oncoproteins. This is evident in @entity1 ( @entity1 ) where the oncoprotein and transcription factor @entity7 is over expressed and essential to continued proliferation and @entity0 cell survival. Historically, targeting transcription factors in the context of @entity0 has been very challenging. Nevertheless, we formulated a DNA vaccine to generate a @entity7 -specific immune response in the belief @entity7 peptides might be aberrantly presented on the cell surface of @entity1 cells. @entity7 , like many @entity0 antigens, is weakly immunogenic as it is a 'self' antigen and is subject to tolerance. To break tolerance, a fusion vaccine was generated comprising a full-length @entity7 complementary DNA (cDNA) flanked by two potent @entity6 -epitopes derived from @entity3 toxoid. Vaccination was achieved against @entity0 initiated by two distinct highly aggressive, syngeneic @entity0 cell lines (CT26 and MC38) that express @entity7 . This was done in BALB/c and C57BL/6 @entity2 strains respectively. We introduced multiple inactivating mutations into the oncogene sequence for safety and sub-cloned the cDNA into a Food and Drug Administration (FDA)-compliant vector. We used low dose @entity4 (CY) to overcome T-regulatory cell immune suppression, and anti-program cell death receptor 1 (anti- @entity5 ) antibodies to block T-cell exhaustion. Anti-PD-1 administered alone slightly delayed @entity0 growth in MC38 and more effectively in CT26 bearing @entity2 , while CY treatment alone did not. We found that therapeutic vaccination elicits protection when MC38 @entity0 burden is low, mounts @entity0 -specific cell killing and affords enhanced protection when MC38 and CT26 @entity0 burden is higher but only in combination with anti-PD-1 antibody or low dose CY, respectively.

title: Therapeutic DNA vaccination against XXXX by targeting the @entity7 oncoprotein.

answer: @entity1


abstract: AIM: The aim of this study was to investigate the relationship between @entity1 and lower urinary tract symptoms and prostate volume in @entity0 who underwent prostate biopsies. MATERIALS AND METHODS: Between December 2008 and November 2009, transrectal ultrasound-guided prostate biopsy was performed on @entity0 who had elevated @entity2 levels or abnormal digital rectal examination findings. A total of 211 @entity0 were included in this study. Prostate volumes, International Prostate Symptom Score (IPSS) values, and the @entity0 's height and weight were all recorded during the biopsy. Body mass index (BMI) <18.5 was determined as underweight, 18.5-23.0 normal, 23.0-27.5 overweight, and >27.5 @entity1 . RESULTS: The mean age of the @entity0 was 68.0    6.3 years, and the mean BMI was 28.0    4.9 kg/m(2). The mean prostate volume of the normal, overweight, and @entity1 groups was 30, 50, and 70 ml, respectively. The positive and statistically significant correlation between BMI and prostate volume was determined (P < 0.001). According to BMI, the mean IPSS was 8.0, 16.5, and 20.0 in the groups, respectively. Similarly, a statistically positive correlation between BMI and IPSS was demonstrated (P < 0.001). CONCLUSIONS: As the result of a rise in BMI, prostate volumes and IPSS increase in @entity0 . Prostate volume and IPSS decrease due to weight loss, and hence that fewer urinary symptoms occur, and the quality-of-life of @entity0 may increase.

title: Effect of XXXX on International Prostate Symptom Score and prostate volume.

answer: @entity1


abstract: UNASSIGNED: In order to assess potential associations between @entity1 ( @entity1 ) phenotype, functional @entity2 and fecal microbiota, we recruited simplex families, which had only a single @entity1 proband and neurotypical (NT) siblings, through the Simons Simplex Community at the Interactive @entity5 Network (SSC@IAN). Fecal samples and metadata related to functional @entity2 and diet were collected from @entity1 probands and NT siblings of @entity1 probands (age 7-14). @entity3 ( @entity3 ) were assessed using the parent-completed ROME III questionnaire for pediatric FGIDs, and problem behaviors were assessed using the @entity0 Behavior Check List (CBCL). Targeted quantitative polymerase chain reaction (qPCR) assays were conducted on selected taxa implicated in @entity1 , including Sutterella spp., Bacteroidetes spp. and Prevotella spp. Illumina sequencing of the V1V2 and the V1V3 regions of the bacterial 16S rRNA genes from fecal DNA was performed to an average depth of 208,000 and 107,000 high-quality reads respectively. Twenty-five of 59 @entity1 @entity0 and 13 of 44 NT siblings met ROME III criteria for at least one @entity3 . Functional @entity4 was more prevalent in @entity1 (17 of 59) compared to NT siblings (6 of 44, P = 0.035). The mean CBCL scores in NT siblings with @entity3 , @entity1 @entity0 with @entity3 and @entity1 without @entity3 were comparably higher (58-62 vs. 44, P < 0.0001) when compared to NT @entity0 without @entity3 . There was no significant difference in macronutrient intake between @entity1 and NT siblings. There was no significant difference in @entity1 severity scores between @entity1 @entity0 with and without @entity3 . No significant difference in diversity or overall microbial composition was detected between @entity1 @entity0 with NT siblings. Exploratory analysis of the 16S rRNA sequencing data, however, identified several low abundance taxa binned at the genus level that were associated with @entity1 and/or first order @entity1 * @entity3 interactions (FDR <0.1).

title: Comparison of Fecal Microbiota in @entity0 with XXXX Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection.

answer: @entity5


abstract: UNASSIGNED: In order to assess potential associations between @entity1 ( @entity1 ) phenotype, functional @entity2 and fecal microbiota, we recruited simplex families, which had only a single @entity1 proband and neurotypical (NT) siblings, through the Simons Simplex Community at the Interactive @entity5 Network (SSC@IAN). Fecal samples and metadata related to functional @entity2 and diet were collected from @entity1 probands and NT siblings of @entity1 probands (age 7-14). @entity3 ( @entity3 ) were assessed using the parent-completed ROME III questionnaire for pediatric FGIDs, and problem behaviors were assessed using the @entity0 Behavior Check List (CBCL). Targeted quantitative polymerase chain reaction (qPCR) assays were conducted on selected taxa implicated in @entity1 , including Sutterella spp., Bacteroidetes spp. and Prevotella spp. Illumina sequencing of the V1V2 and the V1V3 regions of the bacterial 16S rRNA genes from fecal DNA was performed to an average depth of 208,000 and 107,000 high-quality reads respectively. Twenty-five of 59 @entity1 @entity0 and 13 of 44 NT siblings met ROME III criteria for at least one @entity3 . Functional @entity4 was more prevalent in @entity1 (17 of 59) compared to NT siblings (6 of 44, P = 0.035). The mean CBCL scores in NT siblings with @entity3 , @entity1 @entity0 with @entity3 and @entity1 without @entity3 were comparably higher (58-62 vs. 44, P < 0.0001) when compared to NT @entity0 without @entity3 . There was no significant difference in macronutrient intake between @entity1 and NT siblings. There was no significant difference in @entity1 severity scores between @entity1 @entity0 with and without @entity3 . No significant difference in diversity or overall microbial composition was detected between @entity1 @entity0 with NT siblings. Exploratory analysis of the 16S rRNA sequencing data, however, identified several low abundance taxa binned at the genus level that were associated with @entity1 and/or first order @entity1 * @entity3 interactions (FDR <0.1).

title: Comparison of Fecal Microbiota in XXXX with @entity5 Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection.

answer: @entity0


abstract: OBJECTIVE: we performed a three-stages door-to-door survey to estimate incidence and prevalence of @entity1 associated with @entity2 seizures (EACS) in a rural area of Bolivia. METHODS: the study was carried out in the Cordillera Province, southern-eastern Bolivia. One hundred fourteen rural communities with a total population of 18,907 inhabitants were included in the survey. In order to identify subjects with EACS, trained fieldworkers administered a validated single screening question to the householders (stage I). A second face-to-face questionnaire was administered to each positive subject (stage II) that, in case of positive answer, underwent a complete neurological examination to confirm the diagnosis (stage III). We estimated age and sex specific life-time and active EACS prevalence at the prevalence day (30th June 2010). Incidence risk was evaluated for the 10-year period between January 2000 and December 2010. RESULTS: on prevalence day we identified 136 subjects with EACS, 124 of whom had active @entity1 . The life-time prevalence of EACS was 7.2/1,000 (7.6/1,000 age-adjusted to the world standard population) while the prevalence of active EACS was 6.6/1,000 (6.7/1,000 age-adjusted to the world standard population). Both life-time and active prevalence showed a peak (10.3/1,000) in the 15-24 years age group and, overall, were higher among @entity0 . During the incidence study period, 105 @entity0 living in the study area had the onset of EACS. The crude incidence risk was 55.4/100,000 (49.5/100,000 age-adjusted to the world standard population). Incidence was slightly but not significantly higher among @entity0 (58.9/100,000 versus 51.9/100,000). CONCLUSIONS: the present study demonstrated a considerable burden of EACS in the Bolivian Chaco, showing prevalence and incidence estimates close to those reported for low and middle- income countries and underlying the need of treatment programs.

title: Prevalence and Incidence of @entity1 Associated with XXXX . A Global Campaign against @entity1 Project.

answer: @entity2


abstract: OBJECTIVE: we performed a three-stages door-to-door survey to estimate incidence and prevalence of @entity1 associated with @entity2 seizures (EACS) in a rural area of Bolivia. METHODS: the study was carried out in the Cordillera Province, southern-eastern Bolivia. One hundred fourteen rural communities with a total population of 18,907 inhabitants were included in the survey. In order to identify subjects with EACS, trained fieldworkers administered a validated single screening question to the householders (stage I). A second face-to-face questionnaire was administered to each positive subject (stage II) that, in case of positive answer, underwent a complete neurological examination to confirm the diagnosis (stage III). We estimated age and sex specific life-time and active EACS prevalence at the prevalence day (30th June 2010). Incidence risk was evaluated for the 10-year period between January 2000 and December 2010. RESULTS: on prevalence day we identified 136 subjects with EACS, 124 of whom had active @entity1 . The life-time prevalence of EACS was 7.2/1,000 (7.6/1,000 age-adjusted to the world standard population) while the prevalence of active EACS was 6.6/1,000 (6.7/1,000 age-adjusted to the world standard population). Both life-time and active prevalence showed a peak (10.3/1,000) in the 15-24 years age group and, overall, were higher among @entity0 . During the incidence study period, 105 @entity0 living in the study area had the onset of EACS. The crude incidence risk was 55.4/100,000 (49.5/100,000 age-adjusted to the world standard population). Incidence was slightly but not significantly higher among @entity0 (58.9/100,000 versus 51.9/100,000). CONCLUSIONS: the present study demonstrated a considerable burden of EACS in the Bolivian Chaco, showing prevalence and incidence estimates close to those reported for low and middle- income countries and underlying the need of treatment programs.

title: Prevalence and Incidence of XXXX Associated with @entity2 . A Global Campaign against @entity1 Project.

answer: @entity1


abstract: OBJECTIVE: we performed a three-stages door-to-door survey to estimate incidence and prevalence of @entity1 associated with @entity2 seizures (EACS) in a rural area of Bolivia. METHODS: the study was carried out in the Cordillera Province, southern-eastern Bolivia. One hundred fourteen rural communities with a total population of 18,907 inhabitants were included in the survey. In order to identify subjects with EACS, trained fieldworkers administered a validated single screening question to the householders (stage I). A second face-to-face questionnaire was administered to each positive subject (stage II) that, in case of positive answer, underwent a complete neurological examination to confirm the diagnosis (stage III). We estimated age and sex specific life-time and active EACS prevalence at the prevalence day (30th June 2010). Incidence risk was evaluated for the 10-year period between January 2000 and December 2010. RESULTS: on prevalence day we identified 136 subjects with EACS, 124 of whom had active @entity1 . The life-time prevalence of EACS was 7.2/1,000 (7.6/1,000 age-adjusted to the world standard population) while the prevalence of active EACS was 6.6/1,000 (6.7/1,000 age-adjusted to the world standard population). Both life-time and active prevalence showed a peak (10.3/1,000) in the 15-24 years age group and, overall, were higher among @entity0 . During the incidence study period, 105 @entity0 living in the study area had the onset of EACS. The crude incidence risk was 55.4/100,000 (49.5/100,000 age-adjusted to the world standard population). Incidence was slightly but not significantly higher among @entity0 (58.9/100,000 versus 51.9/100,000). CONCLUSIONS: the present study demonstrated a considerable burden of EACS in the Bolivian Chaco, showing prevalence and incidence estimates close to those reported for low and middle- income countries and underlying the need of treatment programs.

title: Prevalence and Incidence of @entity1 Associated with @entity2 . A Global Campaign against XXXX Project.

answer: @entity1


abstract: Traditional histopathological diagnosis of @entity0 has been extended in recent years through the results of additional methods. Today, the results of the detection of hormone receptors, @entity3 , and Ki67 antigen are thus an integral part of the histopathological diagnosis. A critical factor for the success of these tests is the fulfillment of pre-analytical phase conditions - i.e. optimal fixation, as well as taking into account the heterogeneous nature of the neoplastic population. In addition to the above-mentioned markers - which have become a routine practice in recent years, there are many efforts to include the molecular characteristics of @entity1 both in @entity1 classification as well as in the prediction of results of @entity1 treatment. Most of the work is based on the use of gene expression profiles. On the basis of the detection of increased or decreased expression of a large number of genes, it is possible to find a set of multiple genes correlating with the biological behavior of the @entity1 . Using this approach, four basic subgroups of @entity0 have been identified - luminal, basal-like, @entity3 enriched and normal gland-like. Over the course of time, the number of molecular categories has expanded - originally a homogenous group of @entity1 has been subclassified into the luminal A, B and C. @entity2 additional subgroups have been identified. However, the results of studies dealing with the analysis of gene expression profiles suggest that our understanding of the biology of @entity0 is far from being complete. The individual categories are defined differently in various publications and thus the comparison of the results of these studies is very difficult. Another approach for the molecular classification of @entity0 is the immunohistochemical detection of various proteins used as a surrogate marker instead of the detection of the mRNA of individual genes. The advantage of this approach is the possibility to use even archive material, as well as much lower costs. On the other hand, its main limitation is the inability of parallel detection of thousands of markers, unlike in genomic profiling. The results of molecular classification are, however, not fundamentally surprising. The fact that @entity0 stem cells can differentiate towards myoepithelial (or basal) and luminal cells has been known for a long time. These two lines of differentiation are - among others - characterized by differential expression of cytoskeletal proteins as well as of other molecules. These findings have been confirmed by the results of molecular studies - either those based on gene expression profiling or immunohistochemical ones. Research results in gene expression profiling have relatively quickly translated into clinical practice. At present, several commercially available certified tests serve as a complementary source of information for decisions about clinical treatment.

title: [Hopes and pitfalls of the molecular classification of XXXX ].

answer: @entity0


abstract: BACKGROUND: Drugs used to treat @entity3 may take weeks to be effective. In the interim, additional 'as required' doses of medication can be used to calm @entity0 in @entity1 wards. The practice is widespread, with 20% to 50% of @entity0 on acute @entity1 wards receiving at least one 'as required' dose of psychotropic medication during their admission. OBJECTIVES: To compare the effects of 'as required' medication regimens with regular patterns of medication for the treatment of @entity3 or behavioural disturbance, thought to be secondary to @entity3 . These regimens may be given alone or in addition to any regular psychotropic medication for the long-term treatment of @entity2 or @entity2 -like illnesses. SEARCH METHODS: We searched the Cochrane @entity2 Group's Trials Register, which is based on regular searches of MEDLINE, EMBASE, PubMed, CINAHL, BIOSIS, AMED, PsycINFO and registries of clinical trials, in November 2001, March 2006, July 2012 andOctober 2013. SELECTION CRITERIA: We aimed to include all relevant randomised controlled trials involving hospital inpatients with @entity2 or @entity2 -like illnesses, comparing any regimen of medication administered for the short-term relief of behavioural disturbance, or @entity3 , to be given at the discretion of ward staff ('as required', 'prn') with fixed non-discretionary patterns of drug administration of the same drug(s). This was in addition to regular psychotropic medication for the long-term treatment of @entity2 or @entity2 -like illnesses where prescribed. DATA COLLECTION AND ANALYSIS: We independently inspected abstracts and papers for inclusion. If trials had been found, we would have extracted data from the papers and quality assessed the data. For dichotomous data we would have calculated the risk ratios (RR), with the 95% confidence intervals (CI). We would have conducted analyses on an intention-to-treat basis. If data were available we would have completed a 'Summary of findings' table using GRADE. MAIN RESULTS: We have not been able to identify any randomised trials comparing 'as required' medication regimens to regular regimens of the same drug. Our main outcomes of interest were important changes in (i) mental state, (ii) behaviour, (iii) dose of medication used, (iv) adverse events, (v) satisfaction with care and (iv) cost of care. AUTHORS' CONCLUSIONS: There is currently no evidence from within randomised trials to support this common practice. Current practice is based on clinical experience and habit rather than high quality evidence.

title: 'As required' medication regimens for seriously mentally ill XXXX in hospital.

answer: @entity0


abstract: IMPORTANCE: After @entity1 ( @entity1 ) relapse while a @entity0 is receiving an injectable disease-modifying drug, many physicians advocate therapy switch, but the relative effectiveness of different switch decisions is often uncertain. OBJECTIVE: To compare the effect of the oral immunomodulator fingolimod with that of all injectable immunomodulators (interferons or @entity3 ) on relapse rate, disability, and treatment persistence in @entity0 with active @entity1 . DESIGN, SETTING, AND @entity0 : Matched retrospective analysis of data collected prospectively from MSBase, an international, observational cohort study. The MSBase cohort represents a population of @entity0 with @entity1 monitored at large @entity1 centers. The analyzed data were collected between July 1996 and April 2014. @entity0 included @entity0 with relapsing-remitting @entity1 who were switching therapy to fingolimod or injectable immunomodulators up to 12 months after on-treatment clinical disease activity (relapse or @entity2 ), matched on demographic and clinical variables. Median follow-up duration was 13.1 months (range, 3-80). Indication and attrition bias were controlled with propensity score matching and pairwise censoring, respectively. Head-to-head analyses of relapse and disability outcomes used paired, weighted, negative binomial models or frailty proportional hazards models adjusted for magnetic resonance imaging variables. Sensitivity analyses were conducted. EXPOSURES: @entity0 had received fingolimod, interferon beta, or @entity3 for a minimum of 3 months following a switch of immunomodulatory therapy. MAIN OUTCOMES AND MEASURES: Annualized relapse rate and proportion of relapse-free @entity0 , as well as the proportion of @entity0 without sustained disability progression. RESULTS: Overall, 379 @entity0 in the injectable group were matched to 148 @entity0 in the fingolimod group. The fingolimod group had a lower mean annualized relapse rate (0.31 vs 0.42; 95% CI, 0.02-0.19; P=.009), lower hazard of first on-treatment relapse (hazard ratio [HR], 0.74; 95% CI, 0.56-0.98; P=.04), lower hazard of disability progression (HR, 0.53; 95% CI, 0.31-0.91; P=.02), higher rate of disability regression (HR, 2.0; 95% CI, 1.2-3.3; P=.005), and lower hazard of treatment discontinuation (HR, 0.55; P=.04) compared with the injectable group. CONCLUSIONS AND RELEVANCE: Switching from injectable immunomodulators to fingolimod is associated with fewer relapses, more favorable disability outcomes, and greater treatment persistence compared with switching to another injectable preparation following on-treatment activity of @entity1 .

title: Comparison of switch to fingolimod or interferon beta/ @entity3 in active XXXX .

answer: @entity1


abstract: IMPORTANCE: After @entity1 ( @entity1 ) relapse while a @entity0 is receiving an injectable disease-modifying drug, many physicians advocate therapy switch, but the relative effectiveness of different switch decisions is often uncertain. OBJECTIVE: To compare the effect of the oral immunomodulator fingolimod with that of all injectable immunomodulators (interferons or @entity3 ) on relapse rate, disability, and treatment persistence in @entity0 with active @entity1 . DESIGN, SETTING, AND @entity0 : Matched retrospective analysis of data collected prospectively from MSBase, an international, observational cohort study. The MSBase cohort represents a population of @entity0 with @entity1 monitored at large @entity1 centers. The analyzed data were collected between July 1996 and April 2014. @entity0 included @entity0 with relapsing-remitting @entity1 who were switching therapy to fingolimod or injectable immunomodulators up to 12 months after on-treatment clinical disease activity (relapse or @entity2 ), matched on demographic and clinical variables. Median follow-up duration was 13.1 months (range, 3-80). Indication and attrition bias were controlled with propensity score matching and pairwise censoring, respectively. Head-to-head analyses of relapse and disability outcomes used paired, weighted, negative binomial models or frailty proportional hazards models adjusted for magnetic resonance imaging variables. Sensitivity analyses were conducted. EXPOSURES: @entity0 had received fingolimod, interferon beta, or @entity3 for a minimum of 3 months following a switch of immunomodulatory therapy. MAIN OUTCOMES AND MEASURES: Annualized relapse rate and proportion of relapse-free @entity0 , as well as the proportion of @entity0 without sustained disability progression. RESULTS: Overall, 379 @entity0 in the injectable group were matched to 148 @entity0 in the fingolimod group. The fingolimod group had a lower mean annualized relapse rate (0.31 vs 0.42; 95% CI, 0.02-0.19; P=.009), lower hazard of first on-treatment relapse (hazard ratio [HR], 0.74; 95% CI, 0.56-0.98; P=.04), lower hazard of disability progression (HR, 0.53; 95% CI, 0.31-0.91; P=.02), higher rate of disability regression (HR, 2.0; 95% CI, 1.2-3.3; P=.005), and lower hazard of treatment discontinuation (HR, 0.55; P=.04) compared with the injectable group. CONCLUSIONS AND RELEVANCE: Switching from injectable immunomodulators to fingolimod is associated with fewer relapses, more favorable disability outcomes, and greater treatment persistence compared with switching to another injectable preparation following on-treatment activity of @entity1 .

title: Comparison of switch to fingolimod or interferon beta/ XXXX in active @entity1 .

answer: @entity3


abstract: OBJECTIVE: To evaluate the efficiency of using a continuous (one-step) protocol with a single medium for the culture of @entity0 embryos in a @entity2 ( @entity2 ). DESIGN: Prospective cohort study on sibling donor oocytes. SETTING: University-affiliated @entity1 ( @entity1 ) center. @entity0 (S): Embryos from 59 @entity0 . INTERVENTION(S): Culture in a @entity2 in a single medium with or without renewal of the medium on day-3. MAIN OUTCOME MEASURE(S): Embryo morphology and morphokinetic parameters, clinical pregnancy, take-home baby rate, and perinatal outcomes. RESULT(S): The blastocyst rates (68.3 vs. 66.8%) and the proportion of @entity3 (transferred plus frozen) obtained with the two-step (80.0%) protocol were statistically significantly similar to those obtained in the one-step protocol (72.2%). Similarly, morphokinetic events from early cleavage until late blastocyst stages were statistically significantly equivalent between both groups. No differences were found either in clinical pregnancy rates when comparing pure transfers performed with embryos selected from the two-step (75.0%), one-step (70.0%, respectively), and mixed (57.1%) groups. A total of 55 out of 91 embryos transferred implanted successfully (60.4%), resulting in a total of 37 newborns with a comparable birth weight mean among groups. CONCLUSION(S): Our findings support the idea that in a @entity2 with a controlled air purification system, @entity0 embryos can be successfully cultured continuously from day 0 onward in single medium with no need to renew it on day-3. This strategy does not affect embryo morphokinetics or development to term and offers more stable culture conditions for embryos as well as practical advantages and reduced costs for the @entity1 laboratory.

title: Blastocyst development in single medium with or without renewal on  day 3: a prospective cohort study on sibling donor oocytes in a XXXX .

answer: @entity2


abstract: OBJECTIVE: Evaluate effect of pelvic floor muscle training (PFMT) on vaginal symptoms and @entity3 , @entity4 and @entity2 in primiparous @entity0 stratified by major or no defects of the levator ani muscle. DESIGN: Randomised controlled trial (RCT). SETTING: Akershus University Hospital, Norway. SAMPLE: About 175 primiparous @entity0 with a singleton vaginal delivery. METHODS: Two-armed assessor blinded parallel group RCT from 6 weeks to 6 months postpartum comparing effect of PFMT versus control. MAIN OUTCOME MEASURES: International Consultation on Incontinence Modular Questionnaire-vaginal symptoms questionnaire (ICIQ-VS) and ICIQ @entity3 module (ICIQ-FLUTSsex). RESULTS: Overall, analysis (n = 175) showed no difference between training and control groups in @entity0 having vaginal symptoms or symptoms related to @entity1 6 months postpartum. The majority of @entity0 (88%) had intercourse and there was no difference between groups. Unadjusted subgroup analysis of @entity0 with a major defect of the levator ani muscle (n = 55) showed that @entity0 in the training group had 45% less risk of having the symptom 'vagina feels loose or lax' compared with the control group (relative risk 0.55, 95% confidence interval 0.31, 0.95; P = 0.03). CONCLUSIONS: Unadjusted analysis showed that in @entity0 with major defect of the levator ani muscle, significantly fewer in the training group had the symptom 'vagina feels loose or lax' compared with the control group. No difference was found between groups for symptoms related to @entity1 . More studies are needed to explore effect of PFMT on vaginal symptoms and @entity1 . TWEETABLE ABSTRACT: Unadjusted analysis shows that PFMT might prevent symptoms of 'vagina feels loose or lax'.

title: Effect of postpartum pelvic floor muscle training on vaginal symptoms and XXXX -secondary analysis of a randomised trial.

answer: @entity1


abstract: UNASSIGNED: Pathogenic and non-pathogenic fungi synthesize glycosphingolipids, which have a crucial role in growth and viability. Glycosphingolipids also contribute to fungal-associated pathogenesis. The opportunistic @entity3 pathogen @entity5 synthesizes phospholipomannan (PLM), which is a glycosphingolipid of the @entity6 family. Through its lipid and glycan moieties, PLM contributes to the initial recognition of the @entity3 , causing @entity4 and persistent @entity2 through activation of host signaling pathways. The lipid moiety of PLM activates the deregulation signaling pathway involved in @entity3 phagocytosis whereas its glycan moiety, composed of b-1,2 @entity7 (b- @entity0 ), participates to inflammatory processes through a mechanism involving Galectin-3. Biosynthesis of PLM b- @entity0 involves two b-1,2 mannosyltransferases (Bmts) that initiate ( @entity8 ) and elongate (Bmt6) the glycan chains. After generation of double bmts   mutants, we show that @entity8 has redundant activity with @entity9 , which can replace @entity8 in @entity8   mutant. We also report that PLM is located in the inner layer of the @entity3 cell wall. PLM seems to be not essential for @entity1 of the @entity3 . However, defect of PLM b-mannosylation increases resistance of @entity5 to inhibitors of b-glucans and chitin synthesis, highlighting a role of PLM in cell wall homeostasis.

title: Initiation of phospholipomannan b-1,2 mannosylation involves Bmts with redundant activity, influences its cell wall location and regulates b-glucans homeostasis but is dispensable for @entity5 XXXX .

answer: @entity1


abstract: UNASSIGNED: Pathogenic and non-pathogenic fungi synthesize glycosphingolipids, which have a crucial role in growth and viability. Glycosphingolipids also contribute to fungal-associated pathogenesis. The opportunistic @entity3 pathogen @entity5 synthesizes phospholipomannan (PLM), which is a glycosphingolipid of the @entity6 family. Through its lipid and glycan moieties, PLM contributes to the initial recognition of the @entity3 , causing @entity4 and persistent @entity2 through activation of host signaling pathways. The lipid moiety of PLM activates the deregulation signaling pathway involved in @entity3 phagocytosis whereas its glycan moiety, composed of b-1,2 @entity7 (b- @entity0 ), participates to inflammatory processes through a mechanism involving Galectin-3. Biosynthesis of PLM b- @entity0 involves two b-1,2 mannosyltransferases (Bmts) that initiate ( @entity8 ) and elongate (Bmt6) the glycan chains. After generation of double bmts   mutants, we show that @entity8 has redundant activity with @entity9 , which can replace @entity8 in @entity8   mutant. We also report that PLM is located in the inner layer of the @entity3 cell wall. PLM seems to be not essential for @entity1 of the @entity3 . However, defect of PLM b-mannosylation increases resistance of @entity5 to inhibitors of b-glucans and chitin synthesis, highlighting a role of PLM in cell wall homeostasis.

title: Initiation of phospholipomannan b-1,2 mannosylation involves Bmts with redundant activity, influences its cell wall location and regulates b-glucans homeostasis but is dispensable for XXXX @entity1 .

answer: @entity5


abstract: OBJECTIVE: This study aims to examine the prevalence and diameter of the bony canal structure of the @entity2 ( @entity2 ), @entity1 height, and distance of its inferior border from the alveolar crest using cone-beam computed tomography (CBCT). METHODS: CBCT images of maxilla in 116 @entity0 were randomly selected from @entity0 who underwent maxillary sinus augmentation procedure and/or posterior teeth implant therapy from April 2011 to September 2012. The lower border of the bony canal to the alveolar crest, diameter of the bony canal, and @entity1 height below the sinus floor to the ridge crest were measured from CBCT scans. Data were presented using descriptive statistics. RESULTS: The prevalence of the bony canal was 75.14% (133/177). The mean diameter of the bony canal was (0.96    0.29) mm. The @entity1 height was (7.14    3.64) mm. The distance of the bony canal's inferior border from the alveolar crest was (17.92    5.68) mm. No statistically significant differences between the right and left sides were observed (F = 0.295, P > 0.05). The mean diameter of the bony canal was significantly smaller in females than that in males (F = 0.187, P < 0.05). The maxillary alveolar dimension was significantly correlated with the @entity1 height. CONCLUSION: The results from this study suggest that CBCT is a valuable tool in evaluating the presence of the bony canal of the PSAAs efore maxillary sinus surgery.

title: [Evaluating the bony canal structure of the XXXX using cone-beam computed tomography].

answer: @entity2


abstract: OBJECTIVE: To evaluate the clinical and radiographic characteristics of @entity5 @entity7 of the petrous apex, as well as the outcomes of operative and conservative management. STUDY DESIGN: Retrospective chart review. SETTING: Two independent tertiary academic referral centers. @entity0 : Adult and pediatric @entity0 with @entity5 @entity7 of the petrous apex were identified from the experience of two separate centers. @entity0 were included after radiographic diagnosis and clinical evaluation. All @entity0 with less than 6 months of follow-up and those with iatrogenic postoperative @entity5 @entity7 were excluded. INTERVENTION: Demographic information, presenting symptoms, imaging characteristics, treatment strategies, and outcomes were recorded. MAIN OUTCOME MEASURES: @entity0 were evaluated on the basis of symptom and radiographic evolution during time, with or without operative intervention. RESULTS: Ninety petrous apex @entity5 @entity7 were analyzed (57.8% females, 55.6% right-sided). The average age at presentation was 43.1 years (median 42.0, range 8.0-77.0 years). The most common presenting symptom was @entity1 (56.7%), and the average lesion size in the greatest dimension was 2.1cm (median 1.7, range 0.7-5.0cm). During a mean follow-up of 46.0 months, no cases of spontaneous @entity6 or @entity4 occurred. Twenty-three @entity0 (25.6%) ultimately underwent surgical management, most commonly for intractable @entity1 , and only 47.8% of these @entity0 experienced durable symptom improvement by their last postoperative follow-up. CONCLUSION: Many @entity5 @entity7 of the petrous apex remain stable during time and can be safely managed with primary observation. Surgery should be reserved for lesions that are causing, or threatening, @entity2 because of mass effect or erosion of critical structures such as the otic capsule. @entity3 associated with @entity5 @entity7 may improve after operative management; however, symptoms such as @entity1 and @entity8 are less likely to benefit from surgery. As a general guideline, in the presence of a radiologically stable @entity5 @entity7 in the petrous apex, alternative etiologies for @entity1 and @entity8 should be considered and treated before offering surgical intervention.

title: The Natural History and Management of Petrous Apex @entity5 XXXX .

answer: @entity7