abstract: The mechanisms responsible for malignant @entity3 associated with reperfusion of @entity0 myocardium were delineated with a computerized, three-dimensional mapping system, with simultaneous eight-level transmural recordings from 232 bipolar sites. In six @entity6 -anesthetized @entity1 , regional @entity0 was induced for 10 min by occlusion of the left anterior descending coronary artery, followed by reperfusion. At 10 min after @entity0 , just before reperfusion, total ventricular activation time during sinus rhythm was significantly delayed (63 +/- 8 vs 25 +/- 2 msec before @entity0 , p less than .001). @entity4 ( @entity4 ) occurred within 15 sec after reperfusion and in three animals culminated in @entity5 . In 75% of cases of nonsustained @entity4 , initiation occurred in the subendocardium, at the border of the reperfused zone via a mechanism not involving reentry, as determined by the fact that continuous activation was not apparent and the time from the end of the sinus beat to the beginning of @entity4 (142 +/- 14 msec) was not associated with any intervening depolarizations. In the remaining 25% of cases of nonsustained @entity4 , initiation of the @entity4 resulted from intramural reentry in the subendocardium adjacent to the site of delayed midmyocardial activation from the preceding sinus beat (total activation time = 151 +/- 9 msec, p less than .001 vs just before reperfusion). This reentrant mechanism was similar to that responsible for the majority of cases of @entity4 during @entity0 without reperfusion. Maintenance of @entity4 during reperfusion occurred by nonreentrant mechanisms as well as by intramural reentry, with most cases of @entity4 involving both mechanisms. @entity4 leading to @entity5 was initiated in the subendocardium at the border of the reperfused zone by a nonreentrant mechanism and was maintained by both nonreentrant and reentrant mechanisms, at times in combination in the same beat. The coupling interval of the first ectopic beat of @entity4 leading to @entity5 was not significantly different from that of nonsustained @entity4 (199 +/- 16 vs 189 +/- 9 msec, p = NS). However, during the transition from @entity4 to @entity5 , nonreentrant mechanisms arising both in the subendocardium and subepicardium led to very rapid acceleration of the @entity2 to the coupling interval of 92 +/- 2 msec, resulting in enhanced functional block and further conduction delay, with the total activation time of the transition beats exceeding the coupling interval of the @entity2 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: Electrophysiologic mechanisms underlying @entity3 due to reperfusion of XXXX myocardium.

answer: @entity0


abstract: OBJECTIVE: To investigate the effectiveness and safety of a new single-incision mini-sling (SIMS)-Ajust-compared with the standard transobturator midurethral sling (SMUS)-Align-for the treatment of female stress @entity4 (SUI). MATERIALS AND METHODS: A retrospective cohort study was conducted between January 1, 2010 and August 31, 2012. @entity0 with SUI who underwent either SMUS-Align or SIMS-Ajust were recruited. The primary outcomes included operation time, estimated operative @entity2 , @entity3 , and complications. The secondary outcomes included subjective and objective success, defined as an International Consultation on Incontinence Questionnaire (ICIQ) score of 0 or improvement as felt by the @entity0 and a long-term complication, such as @entity5 and @entity6 after 6 months and 12 months of follow-up. RESULTS: A total of 136 @entity0 were enrolled, including 76 receiving SMUS-Align and 60 receiving SIMS-Ajust. Baseline characteristics of the @entity0 in both groups were similar, without a statistically significant difference. Primary outcomes between both groups were similar, except that @entity0 treated with SIMS-Ajust had statistically significantly shorter operation time (p  =  0.003), less intent to treat (p  <  0.05), and earlier @entity1 (p  =  0.001) than @entity0 treated with SMUS-Align. Secondary outcomes were similar without a significant difference between the two groups (93% vs. 88% success rate in each group). CONCLUSION: Our results showed that SIMS-Ajust was not inferior to SMUS-Align with respect to success rate, and might have a slight advantage in early discharge. A long-term follow-up or prospective study is needed to confirm the above findings.

title: Comparison of single-incision mini-slings (Ajust) and standard transobturator midurethral slings (Align) in the management of female stress XXXX : A 1-year follow-up.

answer: @entity4


abstract: PURPOSE: To assess the influence of radiation volume on outcome in pediatric @entity2 ( @entity2 ). METHODS AND MATERIALS: Thirty @entity0 ranging in age from 2 to 18 years (median 6) with PM-RMS were treated at the Hospital of the University of Pennsylvania and the @entity0 's Hospital of Philadelphia between August 1988 and December 1999. The histologic subtypes included embryonal (n = 26), alveolar (n = 3), and undifferentiated (n = 1). Twenty-seven @entity0 had Group III and three had Group IV disease. Twenty-seven @entity0 underwent biopsy only and three subtotal resection. All @entity0 were treated with multiple-agent chemotherapy and external beam radiotherapy. In 8 @entity0 , all of whom had @entity1 extension, the @entity1 and whole brain were treated as the initial volume. In the remaining @entity0 , most of those treated before 1992 were treated to the prechemotherapy (CMT) @entity1 volume for the entire treatment up to the total dose, which ranged from 45 to 59.4 Gy (median dose 57.9). In contrast, @entity0 treated after 1992 generally received radiation initially to the pre-CMT volume (30.6-40 Gy; median dose 36) followed by a conedown to the post-CMT volume to a final dose of 41.4-55.2 Gy (median 50.4). RESULTS: With a median follow-up of 6.2 years (range 2.1-13.3), the actuarial 5-year overall survival, progression-free survival, and local control rate for the entire group was 82%, 76%, and 76%, respectively. Seven failures and five deaths have been documented. In univariate analysis, histologic type, @entity1 size, and age at diagnosis were found to be predictive of overall survival and local control. No statistically significant difference in overall survival or local control was seen between @entity0 who received a conedown to the post-CMT volume (n = 13) and @entity0 in whom the pre-CMT volume was included for the entire treatment (n = 9). CONCLUSION: Radiotherapy delivered to @entity0 with PM-RMS using a shrinking field technique with a post-CMT volume boost was effective and appears to give results comparable to those of @entity0 in whom the pre-CMT volume was treated for the entire course. The use of such tailored treatment fields is likely to lead to fewer late effects and warrants further investigation.

title: Volumetric considerations in radiotherapy for pediatric XXXX .

answer: @entity2


abstract: PURPOSE: The @entity0 liver is known to be a relatively radiosensitive organ that develops clinically relevant late @entity4 subsequent to whole liver treatment with total doses above 30 Gy in conventional fractionation. Experimental data, as well as clinical series, have demonstrated that @entity6 of solid @entity1 in addition to radiotherapy enhances @entity1 growth inhibition and @entity1 control probability. We therefore developed an experimental model for combined radiotherapy and @entity6 of the liver in transplantable @entity2 Morris @entity5 3924A. METHODS AND MATERIALS: A cube of approximately 8 mm(3) was implanted subcapsularly into the middle liver lobe of 59 male syngenic ACI @entity2 weighing approximately 180-200 g. On Day 16 after @entity1 implantation, irradiation of the @entity3 with either 0 Gy/25 Gy/35 Gy/45 Gy total dose in 10 fractions +/- @entity6 (target temperature 40-42 degrees C) twice a week was initiated. Energy deposition was monitored by temperature probes in the liver and esophagus of the @entity2 . Determination of @entity1 volume with magnetic resonance imaging was performed 2 to 5 weeks after the end of therapy. The @entity1 growth rates could be estimated for 44 @entity2 . If the growth rate was positive (37 @entity2 ), the inverse of the growth rate was interpreted as the time to 10-fold @entity1 volume. Otherwise the maximum observation time was considered as a censored value in a parametric survival analysis. RESULTS: Intrahepatic temperature probes showed a temperature plateau of greater than 40 degrees C after 5 to 8 min subsequent to initiation of @entity6 . The target temperatures could be maintained for at least 22 min > or =40 degrees C and 10 min > or =41 degrees C, respectively. Median plateau temperature in liver, esophagus, and epicutaneously was 41.2 degrees C (standard deviation [SD] 0.7 degrees C; range 38.2 to 43.3 degrees C), 40.4 degrees C (SD 1.08 degrees C; range 38.9 to 41.8 degrees C), and 40.8 degrees C (SD 0.8 degrees C; range 38.2 to 42.7 degrees C), respectively. Elevation of the temperature in the esophagus correlated with intrahepatic temperatures in the range of 39-42 degrees C, r = 0.957. The increase in time to 10-fold @entity1 volume for each step of irradiation dosage was by 34% (95% confidence interval [CI] 20% to 49%) without @entity6 and by 60% (95% CI 47% to 80%) with @entity6 (p < 0.0001). CONCLUSION: Treatment outcome after experimental percutaneous thermoradiotherapy in @entity7 3924A was related to total dose of irradiation and concurrently administered regional @entity6 . An increased radiosensitivity due to @entity6 (<42 degrees C) has to be assumed.

title: Experimental thermoradiotherapy in XXXX .

answer: @entity5


abstract: UNASSIGNED: The aim of this study was to evaluate the quality of the canal fillings performed by thermoplastic technique (Herofill) and @entity2 ( @entity2 ) techniques in oval shaped canals following @entity0 ( @entity0 ) preparation using radiological, stereological, and microscopic evaluation methods. Twelve pairs of oval-shaped root canals were prepared with @entity0 and filled using @entity2 (n   =   12) or the Herofill system (n   =   12). The quality of the root canal filling was evaluated by (i) scoring bidirectional storage phosphor plate images, (ii) stereological (volumetric) analysis of cone beam computerized tomography (CBCT) images, and (iii) microscopic analysis of the cross-sectioned area of the canal and gutta-percha via image analysis software. Chi-square test, t-test, and Mann-Whitney U-tests were used respectively (p   <   0.05) for the aforementioned evaluations. 58.33% of the fillings (total n   =   24) that were found to be sufficient in a bucco-lingual (BL) projection were considered insufficient in the @entity1 ( @entity1 ) projection according to radiological scoring. The difference in the findings between the two types of projections (BL and @entity1 ) was significant (p   <   0.05). The results of the stereological evaluation of CBCT images and image analysis of cross-sections showed no statistically significant difference between the @entity2 and Herofill (p   >   0.05). Herofill was not superior to cold lateral compaction. Stereology can be used to obtain unbiased information about the volume of root canal fillings. Both filling techniques failed to achieve the desirable goal of 0% empty volume in all of the cases and all evaluation systems confirmed this result. SCANNING 38:427-433, 2016.    2015 Wiley Periodicals, Inc.

title: Radiological, stereological, and microscopic evaluation of the quality of canal fillings in oval-shaped root canals prepared with XXXX .

answer: @entity0


abstract: Salvia miltiorrhiza (Danshen) has been widely used in China and other Asian countries for treating various @entity1 resulting from its ability to improve coronary microcirculation and increase coronary blood flow. @entity6 (Tan IIA), the major active lipophilic ingredient responsible for the beneficial actions of Salvia miltiorrhiza, has been shown to induce vasodilation in coronary arteries. Because our recent study identified Tan IIA as a new member of the phytoestrogens, we hypothesized that its action might be mediated by @entity2 receptor (ER) in vascular endothelial cells. The aim of the present study was to assess whether cardiovascular protection exerted by Tan IIA is mediated by the ER signal pathway and whether the genomic or nongenomic action of ER is involved within arteries and vascular endothelial cells. The effect of Tan IIA on blood vessels was investigated by vascular ring assay using endothelium-intact and endothelium-denuded @entity0 aortas. Similar to @entity2 , Tan IIA caused an @entity3 - and endothelium-dependent relaxation, which was blocked by ER antagonist @entity4 . Primary cardiac microvascular endothelial cells were used as a model to study the cellular and molecular mechanisms of Tan IIA-induced vasorelaxation. We demonstrate that Tan IIA is capable of activating the @entity2 receptor signal pathway, leading to increased endothelial @entity3 synthase gene expression, @entity3 production, @entity5 phosphorylation, and Ca mobilization. Collectively, these effects contribute to Tan IIA's vasodilative activity effects of y ER antagonist Cnt of @entity1 . Our findings support a continued effort in discovering and developing novel phytoestrogens as an alternative hormone replacement therapy for safer and more effective treatment of @entity1 .

title: Direct vasorelaxation by a novel phytoestrogen XXXX is mediated by nongenomic action of @entity2 receptor through endothelial @entity3 synthase activation and calcium mobilization.

answer: @entity6


abstract: Salvia miltiorrhiza (Danshen) has been widely used in China and other Asian countries for treating various @entity1 resulting from its ability to improve coronary microcirculation and increase coronary blood flow. @entity6 (Tan IIA), the major active lipophilic ingredient responsible for the beneficial actions of Salvia miltiorrhiza, has been shown to induce vasodilation in coronary arteries. Because our recent study identified Tan IIA as a new member of the phytoestrogens, we hypothesized that its action might be mediated by @entity2 receptor (ER) in vascular endothelial cells. The aim of the present study was to assess whether cardiovascular protection exerted by Tan IIA is mediated by the ER signal pathway and whether the genomic or nongenomic action of ER is involved within arteries and vascular endothelial cells. The effect of Tan IIA on blood vessels was investigated by vascular ring assay using endothelium-intact and endothelium-denuded @entity0 aortas. Similar to @entity2 , Tan IIA caused an @entity3 - and endothelium-dependent relaxation, which was blocked by ER antagonist @entity4 . Primary cardiac microvascular endothelial cells were used as a model to study the cellular and molecular mechanisms of Tan IIA-induced vasorelaxation. We demonstrate that Tan IIA is capable of activating the @entity2 receptor signal pathway, leading to increased endothelial @entity3 synthase gene expression, @entity3 production, @entity5 phosphorylation, and Ca mobilization. Collectively, these effects contribute to Tan IIA's vasodilative activity effects of y ER antagonist Cnt of @entity1 . Our findings support a continued effort in discovering and developing novel phytoestrogens as an alternative hormone replacement therapy for safer and more effective treatment of @entity1 .

title: Direct vasorelaxation by a novel phytoestrogen @entity6 is mediated by nongenomic action of XXXX receptor through endothelial @entity3 synthase activation and calcium mobilization.

answer: @entity2


abstract: Salvia miltiorrhiza (Danshen) has been widely used in China and other Asian countries for treating various @entity1 resulting from its ability to improve coronary microcirculation and increase coronary blood flow. @entity6 (Tan IIA), the major active lipophilic ingredient responsible for the beneficial actions of Salvia miltiorrhiza, has been shown to induce vasodilation in coronary arteries. Because our recent study identified Tan IIA as a new member of the phytoestrogens, we hypothesized that its action might be mediated by @entity2 receptor (ER) in vascular endothelial cells. The aim of the present study was to assess whether cardiovascular protection exerted by Tan IIA is mediated by the ER signal pathway and whether the genomic or nongenomic action of ER is involved within arteries and vascular endothelial cells. The effect of Tan IIA on blood vessels was investigated by vascular ring assay using endothelium-intact and endothelium-denuded @entity0 aortas. Similar to @entity2 , Tan IIA caused an @entity3 - and endothelium-dependent relaxation, which was blocked by ER antagonist @entity4 . Primary cardiac microvascular endothelial cells were used as a model to study the cellular and molecular mechanisms of Tan IIA-induced vasorelaxation. We demonstrate that Tan IIA is capable of activating the @entity2 receptor signal pathway, leading to increased endothelial @entity3 synthase gene expression, @entity3 production, @entity5 phosphorylation, and Ca mobilization. Collectively, these effects contribute to Tan IIA's vasodilative activity effects of y ER antagonist Cnt of @entity1 . Our findings support a continued effort in discovering and developing novel phytoestrogens as an alternative hormone replacement therapy for safer and more effective treatment of @entity1 .

title: Direct vasorelaxation by a novel phytoestrogen @entity6 is mediated by nongenomic action of @entity2 receptor through endothelial XXXX synthase activation and calcium mobilization.

answer: @entity3


abstract: OBJECTIVE: To describe a case of feline sebaceous @entity8 and @entity12 , and its successful treatment with topical @entity6 . ANIMAL: A 5-year-old, male castrated Norwegian Forest cat was presented with a progressive @entity7 . METHODS: Clinical examination and histopathological examination of skin biopsies. RESULTS: There was severe, multifocal, @entity12 and perifollicular @entity7 , moderate @entity9 and sebaceous @entity8 on histopathology. Sebaceous glands were either absent or almost completely effaced by a dense lymphocytic infiltrate. Clinical signs began in spring on the face and neck and progressed over an 18 month period to involve the legs. Initially, topical and systemic antibacterial therapy for a mild @entity10 resulted in partial clinical response. There was no improvement with oral omega 6 @entity6 and surface cleaning. Treatment with a spot-on product containing essential oils, smoothing agents and @entity1 as the sole therapy was associated with a good - but incomplete - clinical response over a 6 month period, with hair regrowth and a marked decrease in @entity7 . This improvement was sustained until 12  months later when a severe deep @entity11 with associated @entity3 and @entity2 occurred. This was symptomatically treated and the cat remained clinically stable for a further 18  months. Periocular and perinasal seborrhoea was a persistent feature. CONCLUSION AND CLINICAL IMPORTANCE: Topical essential @entity5 therapy may offer a viable alternative to @entity0 , which has been reported for the successful treatment of this rare disease in @entity4 .

title: Sebaceous @entity8 and @entity12 in a cat responsive to topical XXXX supplementation.

answer: @entity5


abstract: OBJECTIVE: To describe a case of feline sebaceous @entity8 and @entity12 , and its successful treatment with topical @entity6 . ANIMAL: A 5-year-old, male castrated Norwegian Forest cat was presented with a progressive @entity7 . METHODS: Clinical examination and histopathological examination of skin biopsies. RESULTS: There was severe, multifocal, @entity12 and perifollicular @entity7 , moderate @entity9 and sebaceous @entity8 on histopathology. Sebaceous glands were either absent or almost completely effaced by a dense lymphocytic infiltrate. Clinical signs began in spring on the face and neck and progressed over an 18 month period to involve the legs. Initially, topical and systemic antibacterial therapy for a mild @entity10 resulted in partial clinical response. There was no improvement with oral omega 6 @entity6 and surface cleaning. Treatment with a spot-on product containing essential oils, smoothing agents and @entity1 as the sole therapy was associated with a good - but incomplete - clinical response over a 6 month period, with hair regrowth and a marked decrease in @entity7 . This improvement was sustained until 12  months later when a severe deep @entity11 with associated @entity3 and @entity2 occurred. This was symptomatically treated and the cat remained clinically stable for a further 18  months. Periocular and perinasal seborrhoea was a persistent feature. CONCLUSION AND CLINICAL IMPORTANCE: Topical essential @entity5 therapy may offer a viable alternative to @entity0 , which has been reported for the successful treatment of this rare disease in @entity4 .

title: Sebaceous XXXX and @entity12 in a cat responsive to topical @entity5 supplementation.

answer: @entity8


abstract: OBJECTIVE: To describe a case of feline sebaceous @entity8 and @entity12 , and its successful treatment with topical @entity6 . ANIMAL: A 5-year-old, male castrated Norwegian Forest cat was presented with a progressive @entity7 . METHODS: Clinical examination and histopathological examination of skin biopsies. RESULTS: There was severe, multifocal, @entity12 and perifollicular @entity7 , moderate @entity9 and sebaceous @entity8 on histopathology. Sebaceous glands were either absent or almost completely effaced by a dense lymphocytic infiltrate. Clinical signs began in spring on the face and neck and progressed over an 18 month period to involve the legs. Initially, topical and systemic antibacterial therapy for a mild @entity10 resulted in partial clinical response. There was no improvement with oral omega 6 @entity6 and surface cleaning. Treatment with a spot-on product containing essential oils, smoothing agents and @entity1 as the sole therapy was associated with a good - but incomplete - clinical response over a 6 month period, with hair regrowth and a marked decrease in @entity7 . This improvement was sustained until 12  months later when a severe deep @entity11 with associated @entity3 and @entity2 occurred. This was symptomatically treated and the cat remained clinically stable for a further 18  months. Periocular and perinasal seborrhoea was a persistent feature. CONCLUSION AND CLINICAL IMPORTANCE: Topical essential @entity5 therapy may offer a viable alternative to @entity0 , which has been reported for the successful treatment of this rare disease in @entity4 .

title: Sebaceous @entity8 and XXXX in a cat responsive to topical @entity5 supplementation.

answer: @entity12


abstract: BACKGROUND: @entity6 (HSV) is a rare disease associated with high mortality and morbidity rates. @entity3 can be subdivided into 3 clinical manifestations: isolated @entity5 ( @entity5 ) @entity4 and disseminated disease. Consensus guidelines for diagnostic and therapeutic management are not available. OBJECTIVES: To evaluate the diagnostic work-up and therapeutic management in neonates with suspected or proven @entity3 . STUDY DESIGN: Retrospective study of diagnostic and therapeutic management in all neonates with suspected @entity3 admitted to our neonatal nursery between January 2005 and July 2010. RESULTS: A total 53 neonates with suspected @entity3 were included in the study and classified as @entity1 (n=2), @entity4 (n=41) or disseminated disease (n=10). None of the included @entity0 tested positive for @entity3 . Correct and complete diagnostic work-up was performed in only 11% (6/53) of the cases. All neonates were treated with intravenous @entity2 . CONCLUSIONS: None of the neonates with suspected HSV tested positive. Diagnostic management in neonates with suspected @entity3 was often improper and incomplete. Consensus guidelines to identify low-risk @entity0 in whom HSV testing and @entity2 treatment is not warranted, are urgently needed.

title: Diagnostic and therapeutic management for suspected XXXX .

answer: @entity6


abstract: Aquatic animals use a variety of strategies to reduce the energetic cost of locomotion. Efficient locomotion is particularly important for breath-holding divers because high levels of exercise may quickly deplete @entity0 reserves, leading to the termination of a dive. We investigated the swimming behavior of eight adult @entity2 , which are proficient divers, in McMurdo Sound, Antarctica. A newly developed data logger was attached to free-ranging females at their own breeding sites to record swimming speed, depth, two-dimensional accelerations ( @entity1 frequency and body angle) and temperature. All seals conducted multiple deep dives (the mean dive depth range for each animal was 223.3+/-66.5-297.9+/-164.7 m). Prolonged gliding while descending was observed with thinner females (N=5 seals). But the fatter females (N=3 seals) exhibited only swim-and-glide swimming, characterized by intermittent stroking and fluctuating swim speed, throughout their descent and ascent. The body angles of four of the seals were restricted to less than 30 degrees by the location of breathing holes in the ice and the slope of local bathymetric features. Of these four, the three fatter seals adopted the @entity1 -and-glide method while the other thinner seal descended with prolonged periods of gliding. Prolonged gliding seems to be a more efficient method for locomotion because the surface time between dives of gliding seals was significantly less than that of stroking animals, despite their same @entity1 frequencies.

title: Factors affecting stroking patterns and body angle in diving XXXX under natural conditions.

answer: @entity2


abstract: UNASSIGNED: In @entity2 , undercarboxylated @entity6 (ucOC) improves beta-cell function and @entity7 sensitivity through @entity5 . In @entity0 , levels of total @entity6 (OC) and ucOC were negatively correlated with @entity7 resistance (IR) indices in @entity0 with @entity3 2 @entity1 . Whether ucOC plays a role in @entity4 homeostasis and whether its effect is mediated through @entity5 during pregnancy is unclear. Serum levels of total OC, ucOC, and @entity5 were measured in 130 pregnant @entity0 with varying degrees of IR [ @entity1 ( @entity1 ), n  =  74 and non- @entity1 , n  =  56]. In all @entity0 , total OC and ucOC levels were positively correlated with HOMA-IR and HOMA-%B, and negatively correlated with QUICKI. In contrast, @entity5 levels were negatively correlated with HOMA-IR and positively correlated with QUICKI (P  <  0.01, both). However, neither total OC nor ucOC was associated with @entity5 . Although none of these markers could help distinguish @entity0 with and without @entity1 , total OC and ucOC levels were significantly higher in non- @entity1 @entity0 who had 1 abnormal OGTT value than those who had all normal OGTT values. Total OC and ucOC levels were significantly correlated with @entity7 secretion and IR indices, but not @entity5 levels, in pregnant @entity0 . Changes in OC might be a sensitive response to increased IR during pregnancy, which was not mediated through @entity5 .

title: Undercarboxylated XXXX is associated with @entity7 resistance, but not @entity5 , during pregnancy.

answer: @entity6


abstract: UNASSIGNED: In @entity2 , undercarboxylated @entity6 (ucOC) improves beta-cell function and @entity7 sensitivity through @entity5 . In @entity0 , levels of total @entity6 (OC) and ucOC were negatively correlated with @entity7 resistance (IR) indices in @entity0 with @entity3 2 @entity1 . Whether ucOC plays a role in @entity4 homeostasis and whether its effect is mediated through @entity5 during pregnancy is unclear. Serum levels of total OC, ucOC, and @entity5 were measured in 130 pregnant @entity0 with varying degrees of IR [ @entity1 ( @entity1 ), n  =  74 and non- @entity1 , n  =  56]. In all @entity0 , total OC and ucOC levels were positively correlated with HOMA-IR and HOMA-%B, and negatively correlated with QUICKI. In contrast, @entity5 levels were negatively correlated with HOMA-IR and positively correlated with QUICKI (P  <  0.01, both). However, neither total OC nor ucOC was associated with @entity5 . Although none of these markers could help distinguish @entity0 with and without @entity1 , total OC and ucOC levels were significantly higher in non- @entity1 @entity0 who had 1 abnormal OGTT value than those who had all normal OGTT values. Total OC and ucOC levels were significantly correlated with @entity7 secretion and IR indices, but not @entity5 levels, in pregnant @entity0 . Changes in OC might be a sensitive response to increased IR during pregnancy, which was not mediated through @entity5 .

title: Undercarboxylated @entity6 is associated with @entity7 resistance, but not XXXX , during pregnancy.

answer: @entity5


abstract: UNASSIGNED: In @entity2 , undercarboxylated @entity6 (ucOC) improves beta-cell function and @entity7 sensitivity through @entity5 . In @entity0 , levels of total @entity6 (OC) and ucOC were negatively correlated with @entity7 resistance (IR) indices in @entity0 with @entity3 2 @entity1 . Whether ucOC plays a role in @entity4 homeostasis and whether its effect is mediated through @entity5 during pregnancy is unclear. Serum levels of total OC, ucOC, and @entity5 were measured in 130 pregnant @entity0 with varying degrees of IR [ @entity1 ( @entity1 ), n  =  74 and non- @entity1 , n  =  56]. In all @entity0 , total OC and ucOC levels were positively correlated with HOMA-IR and HOMA-%B, and negatively correlated with QUICKI. In contrast, @entity5 levels were negatively correlated with HOMA-IR and positively correlated with QUICKI (P  <  0.01, both). However, neither total OC nor ucOC was associated with @entity5 . Although none of these markers could help distinguish @entity0 with and without @entity1 , total OC and ucOC levels were significantly higher in non- @entity1 @entity0 who had 1 abnormal OGTT value than those who had all normal OGTT values. Total OC and ucOC levels were significantly correlated with @entity7 secretion and IR indices, but not @entity5 levels, in pregnant @entity0 . Changes in OC might be a sensitive response to increased IR during pregnancy, which was not mediated through @entity5 .

title: Undercarboxylated @entity6 is associated with XXXX resistance, but not @entity5 , during pregnancy.

answer: @entity7


abstract: BACKGROUND: @entity2 ( @entity2 ) consist of complex movements involving proximal segments of the limbs and trunk that appear violent and inappropriate for the situation. METHODS: We analyzed hypermotor @entity2 videos in @entity2 -free @entity0 (Engel class I) following resective @entity1 surgery. After completion of video analysis, we reviewed EEG and neuroimaging data. RESULTS: Search of our @entity1 surgery database yielded 116 @entity0 classified as having hypermotor @entity2 between 1996 and 2013. From this subset, 17/31 (55%) @entity0 had been @entity2 -free for >6months (mean follow-up: 3.3years). Mean @entity2 duration was 35s (range: 6-91s), of which the HM phase lasted a mean of 22s (range: 3-53s). In 16 @entity0 (95%), hypermotor activity was seen at or within 10s of clinical @entity2 onset. Type I semiology occurred in 6 @entity0 , type II semiology in 10 @entity0 , and 1 @entity0 exhibited features of both. Type I and type II semiologies were noted in @entity0 who had frontal lobe as well as extrafrontal resections. Nonversive head and body turning occurred in 10 @entity0 (ranging from 90   to 270  ) which was ipsilateral to the side of resection in all @entity0 and seen both in frontal and extrafrontal resections. Six out of eleven @entity0 with abnormal MRI and 4/6 @entity0 with nonlesional MRI underwent invasive EEG evaluation. Eight @entity0 (47%) had frontal lobe resection, 4/17 (23%) @entity0 had temporal lobe resection, and one @entity0 each had parietal lobe, insular, temporoparietooccipital, or motor sparing resection; 1 @entity0 had functional hemispherectomy. CONCLUSION: Hypermotor semiology typically occurs at or within 10s after @entity2 onset. Ipsilateral head/body turning appears to be of lateralizing value whereas asymmetry of limb movement was not lateralizing. Hypermotor semiology is most often seen in @entity3 but may occur in @entity2 arising from other locations.

title: Semiology of hypermotor (hyperkinetic) XXXX .

answer: @entity2


abstract: BACKGROUND AND AIMS: Hemodialysis @entity0 have an enhanced risk for @entity2 . Cardiac biomarkers provide useful information for stratifying their risk. However the prognosis value of @entity4 kinase MB isoenzyme (CKMB) has not yet been validated in this population. The aim of the present study is to determine the predictable value of CK-MB in hemodialysis. METHODS: A cohort of 211 hemodialysis @entity0 (58.3% male, median age 73 (60-80) years) were followed for 39 (19-56) months. Cardiac biomarkers including CKMB were recorded at baseline. Factors associated to CKMB and prognosis value of this biomarker was studied. RESULTS: The median value of CKMB was 1 (1-2) ng/mL with no @entity0 exceeding normal laboratory values. Previous @entity3 , @entity1 , @entity5 were associated with higher levels of CKMB. Ninety-four @entity0 (44.5%) @entity2 were recorded. CKMB levels >= 2ng/mL was independently associated to @entity2 during the follow up after adjusting. Adding CKMB to a model including several variables for predicting @entity2 , resulted in 17% improvement in risk discrimination (IDI) with a relative IDI of 9.9% (p=0.04). CONCLUSIONS: CKMB is a good marker for stratifying cardiovascular risk in hemodialysis @entity0 and adds prognosis information to other well known independent predictors for @entity2 .

title: XXXX -kinase and dialysis @entity0 , a helpful tool for stratifying cardiovascular risk?

answer: @entity4


abstract: BACKGROUND AND AIMS: Hemodialysis @entity0 have an enhanced risk for @entity2 . Cardiac biomarkers provide useful information for stratifying their risk. However the prognosis value of @entity4 kinase MB isoenzyme (CKMB) has not yet been validated in this population. The aim of the present study is to determine the predictable value of CK-MB in hemodialysis. METHODS: A cohort of 211 hemodialysis @entity0 (58.3% male, median age 73 (60-80) years) were followed for 39 (19-56) months. Cardiac biomarkers including CKMB were recorded at baseline. Factors associated to CKMB and prognosis value of this biomarker was studied. RESULTS: The median value of CKMB was 1 (1-2) ng/mL with no @entity0 exceeding normal laboratory values. Previous @entity3 , @entity1 , @entity5 were associated with higher levels of CKMB. Ninety-four @entity0 (44.5%) @entity2 were recorded. CKMB levels >= 2ng/mL was independently associated to @entity2 during the follow up after adjusting. Adding CKMB to a model including several variables for predicting @entity2 , resulted in 17% improvement in risk discrimination (IDI) with a relative IDI of 9.9% (p=0.04). CONCLUSIONS: CKMB is a good marker for stratifying cardiovascular risk in hemodialysis @entity0 and adds prognosis information to other well known independent predictors for @entity2 .

title: @entity4 -kinase and dialysis XXXX , a helpful tool for stratifying cardiovascular risk?

answer: @entity0


abstract: UNASSIGNED: @entity4 @entity0 experience high levels of @entity3 during diagnoses and intensive treatments. The aim of the present study is to explore the effects of positive psychological resources on @entity2 in @entity4 @entity0 . This survey was conducted in a hospital during the period from July 2013 to April 2014. A total of 300 inpatients were recruited and finally 227 of them completed the questionnaires. Questionnaires included demographic and clinical variables, the Center for Epidemiologic Studies Depression Scale, the Self-Rating @entity1 Scale, the Life Orientation Scale-Revised, the General Perceived Self-Efficacy Scale, and the Resilience Scale-14. Results showed that the prevalence of @entity2 was 66.1 and 45.8%, respectively. Both optimism (b  =  -.479, p  <  .001) and resilience (b  =  -.174, p  <  .05) were negatively associated with @entity2 , and optimism (b  =  -.393, p  <  .001) was negatively associated with @entity1 . However, resilience (b  =  -.133, p  >  .05) was not significantly associated with @entity1 , and self-efficacy was not significantly associated with @entity2 (b  =  -.032, p  >  .05) or @entity1 (b  =  -.055, p  >  .05). The results suggest that @entity4 @entity0 who possess high levels of positive psychological resources may have fewer symptoms of @entity3 . The findings indicate that enhancing positive psychological resources can be considered in developing intervention strategies for decreasing @entity2 .

title: Exploring correlations between positive psychological resources and symptoms of XXXX among @entity4 @entity0 : a cross-sectional study.

answer: @entity3


abstract: UNASSIGNED: @entity4 @entity0 experience high levels of @entity3 during diagnoses and intensive treatments. The aim of the present study is to explore the effects of positive psychological resources on @entity2 in @entity4 @entity0 . This survey was conducted in a hospital during the period from July 2013 to April 2014. A total of 300 inpatients were recruited and finally 227 of them completed the questionnaires. Questionnaires included demographic and clinical variables, the Center for Epidemiologic Studies Depression Scale, the Self-Rating @entity1 Scale, the Life Orientation Scale-Revised, the General Perceived Self-Efficacy Scale, and the Resilience Scale-14. Results showed that the prevalence of @entity2 was 66.1 and 45.8%, respectively. Both optimism (b  =  -.479, p  <  .001) and resilience (b  =  -.174, p  <  .05) were negatively associated with @entity2 , and optimism (b  =  -.393, p  <  .001) was negatively associated with @entity1 . However, resilience (b  =  -.133, p  >  .05) was not significantly associated with @entity1 , and self-efficacy was not significantly associated with @entity2 (b  =  -.032, p  >  .05) or @entity1 (b  =  -.055, p  >  .05). The results suggest that @entity4 @entity0 who possess high levels of positive psychological resources may have fewer symptoms of @entity3 . The findings indicate that enhancing positive psychological resources can be considered in developing intervention strategies for decreasing @entity2 .

title: Exploring correlations between positive psychological resources and symptoms of @entity3 among XXXX @entity0 : a cross-sectional study.

answer: @entity4


abstract: UNASSIGNED: @entity4 @entity0 experience high levels of @entity3 during diagnoses and intensive treatments. The aim of the present study is to explore the effects of positive psychological resources on @entity2 in @entity4 @entity0 . This survey was conducted in a hospital during the period from July 2013 to April 2014. A total of 300 inpatients were recruited and finally 227 of them completed the questionnaires. Questionnaires included demographic and clinical variables, the Center for Epidemiologic Studies Depression Scale, the Self-Rating @entity1 Scale, the Life Orientation Scale-Revised, the General Perceived Self-Efficacy Scale, and the Resilience Scale-14. Results showed that the prevalence of @entity2 was 66.1 and 45.8%, respectively. Both optimism (b  =  -.479, p  <  .001) and resilience (b  =  -.174, p  <  .05) were negatively associated with @entity2 , and optimism (b  =  -.393, p  <  .001) was negatively associated with @entity1 . However, resilience (b  =  -.133, p  >  .05) was not significantly associated with @entity1 , and self-efficacy was not significantly associated with @entity2 (b  =  -.032, p  >  .05) or @entity1 (b  =  -.055, p  >  .05). The results suggest that @entity4 @entity0 who possess high levels of positive psychological resources may have fewer symptoms of @entity3 . The findings indicate that enhancing positive psychological resources can be considered in developing intervention strategies for decreasing @entity2 .

title: Exploring correlations between positive psychological resources and symptoms of @entity3 among @entity4 XXXX : a cross-sectional study.

answer: @entity0


abstract: OBJECTIVE: To identify novel biomarker(s) for @entity3 ( @entity2 ) using a metabolomics approach. METHOD: We utilized a two-stage case-control study design. Plasma samples were collected from knee @entity2 @entity0 and healthy controls after 8-h fasting and metabolically profiled using a targeted metabolomics assay kit. Linear regression was used to identify novel metabolic markers for @entity2 . Receiver operating characteristic (ROC) analysis was used to examine diagnostic values. Gene expression analysis was performed on @entity0 cartilage to explore the potential mechanism for the novel @entity2 marker(s). RESULTS: Sixty-four knee @entity2 @entity0 and 45 controls were included in the discovery stage and 72 knee @entity2 @entity0 and 76 age and sex matched controls were included in the validation stage. We identified and confirmed six metabolites that were significantly associated with knee @entity2 , of which @entity1 was the most significant metabolite (P  <  3.5  *  10(-13)) with knee @entity2 @entity0 having on average 69   M lower than that in controls. ROC analysis showed that @entity1 had the greatest diagnostic value with area under the curve (AUC) of 0.984. The optimal cutoff of @entity1 concentration was 57   M with 98.3% sensitivity and 89% specificity. The depletion of @entity1 in @entity2 @entity0 was most likely due to the over activity of @entity1 to @entity4 pathway, leading to imbalance between cartilage repair and degradation. CONCLUSION: @entity1 is significantly depleted in refractory knee @entity2 @entity0 . Further studies within a longitudinal setting are required to examine whether @entity1 can predict early @entity2 changes.

title: Metabolomic analysis of @entity0 plasma reveals that @entity1 is depleted in XXXX @entity0 .

answer: @entity3


abstract: OBJECTIVE: To identify novel biomarker(s) for @entity3 ( @entity2 ) using a metabolomics approach. METHOD: We utilized a two-stage case-control study design. Plasma samples were collected from knee @entity2 @entity0 and healthy controls after 8-h fasting and metabolically profiled using a targeted metabolomics assay kit. Linear regression was used to identify novel metabolic markers for @entity2 . Receiver operating characteristic (ROC) analysis was used to examine diagnostic values. Gene expression analysis was performed on @entity0 cartilage to explore the potential mechanism for the novel @entity2 marker(s). RESULTS: Sixty-four knee @entity2 @entity0 and 45 controls were included in the discovery stage and 72 knee @entity2 @entity0 and 76 age and sex matched controls were included in the validation stage. We identified and confirmed six metabolites that were significantly associated with knee @entity2 , of which @entity1 was the most significant metabolite (P  <  3.5  *  10(-13)) with knee @entity2 @entity0 having on average 69   M lower than that in controls. ROC analysis showed that @entity1 had the greatest diagnostic value with area under the curve (AUC) of 0.984. The optimal cutoff of @entity1 concentration was 57   M with 98.3% sensitivity and 89% specificity. The depletion of @entity1 in @entity2 @entity0 was most likely due to the over activity of @entity1 to @entity4 pathway, leading to imbalance between cartilage repair and degradation. CONCLUSION: @entity1 is significantly depleted in refractory knee @entity2 @entity0 . Further studies within a longitudinal setting are required to examine whether @entity1 can predict early @entity2 changes.

title: Metabolomic analysis of @entity0 plasma reveals that XXXX is depleted in @entity3 @entity0 .

answer: @entity1


abstract: OBJECTIVE: To identify novel biomarker(s) for @entity3 ( @entity2 ) using a metabolomics approach. METHOD: We utilized a two-stage case-control study design. Plasma samples were collected from knee @entity2 @entity0 and healthy controls after 8-h fasting and metabolically profiled using a targeted metabolomics assay kit. Linear regression was used to identify novel metabolic markers for @entity2 . Receiver operating characteristic (ROC) analysis was used to examine diagnostic values. Gene expression analysis was performed on @entity0 cartilage to explore the potential mechanism for the novel @entity2 marker(s). RESULTS: Sixty-four knee @entity2 @entity0 and 45 controls were included in the discovery stage and 72 knee @entity2 @entity0 and 76 age and sex matched controls were included in the validation stage. We identified and confirmed six metabolites that were significantly associated with knee @entity2 , of which @entity1 was the most significant metabolite (P  <  3.5  *  10(-13)) with knee @entity2 @entity0 having on average 69   M lower than that in controls. ROC analysis showed that @entity1 had the greatest diagnostic value with area under the curve (AUC) of 0.984. The optimal cutoff of @entity1 concentration was 57   M with 98.3% sensitivity and 89% specificity. The depletion of @entity1 in @entity2 @entity0 was most likely due to the over activity of @entity1 to @entity4 pathway, leading to imbalance between cartilage repair and degradation. CONCLUSION: @entity1 is significantly depleted in refractory knee @entity2 @entity0 . Further studies within a longitudinal setting are required to examine whether @entity1 can predict early @entity2 changes.

title: Metabolomic analysis of XXXX plasma reveals that @entity1 is depleted in @entity3 @entity0 .

answer: @entity0


abstract: OBJECTIVE: To identify novel biomarker(s) for @entity3 ( @entity2 ) using a metabolomics approach. METHOD: We utilized a two-stage case-control study design. Plasma samples were collected from knee @entity2 @entity0 and healthy controls after 8-h fasting and metabolically profiled using a targeted metabolomics assay kit. Linear regression was used to identify novel metabolic markers for @entity2 . Receiver operating characteristic (ROC) analysis was used to examine diagnostic values. Gene expression analysis was performed on @entity0 cartilage to explore the potential mechanism for the novel @entity2 marker(s). RESULTS: Sixty-four knee @entity2 @entity0 and 45 controls were included in the discovery stage and 72 knee @entity2 @entity0 and 76 age and sex matched controls were included in the validation stage. We identified and confirmed six metabolites that were significantly associated with knee @entity2 , of which @entity1 was the most significant metabolite (P  <  3.5  *  10(-13)) with knee @entity2 @entity0 having on average 69   M lower than that in controls. ROC analysis showed that @entity1 had the greatest diagnostic value with area under the curve (AUC) of 0.984. The optimal cutoff of @entity1 concentration was 57   M with 98.3% sensitivity and 89% specificity. The depletion of @entity1 in @entity2 @entity0 was most likely due to the over activity of @entity1 to @entity4 pathway, leading to imbalance between cartilage repair and degradation. CONCLUSION: @entity1 is significantly depleted in refractory knee @entity2 @entity0 . Further studies within a longitudinal setting are required to examine whether @entity1 can predict early @entity2 changes.

title: Metabolomic analysis of @entity0 plasma reveals that @entity1 is depleted in @entity3 XXXX .

answer: @entity0


abstract: AIM: The aim of this study was to determine the effect of low-dose @entity1 on venous leg @entity2 when used in addition to compression. BACKGROUND: The mainstay of treatment for @entity3 is compression therapy and there are few adjuvant treatments to accelerate healing. DESIGN: Pragmatic, community-based, double-blind, randomized trial. METHODS: @entity0 with @entity3 will receive either 150  mg @entity1 or placebo daily for up to 24  weeks. @entity0 will receive background treatment with compression therapy (system of choice guided by @entity0 and/or clinical preference) delivered through district nursing services. The primary outcome will be time-to-healing. Secondary outcomes will include proportion healed at 24  weeks, change in @entity2 area, change in health-related quality of life, adherence, efficacy of blinding and adverse events. The trial was funded in June 2014. DISCUSSION: The trial commenced in March 2015 and is successfully recruiting. The trial is one of three trials that will contribute to an individual @entity0 data meta-analysis to be undertaken at the York Trials Centre. TRIAL REGISTRATION: Registered 5 June 2014 ClinicalTrials.gov NCT02158806. Protocol version 1  1, 14 April 2015.

title: Low-dose XXXX as an adjuvant treatment for venous leg ulceration: study protocol for a randomized controlled trial (Aspirin4VLU).

answer: @entity1


abstract: OBJECTIVE: To compare the clinical efficacy on the motor impairment of knee joint after tracture operation between the combined therapeutic method of relaxing needling manipulation and exercise therapy and the simple exercise therapy. METHODS: Sixty-four @entity0 after the operation for the @entity2 of femoral shaft were randomized into a relaxing needling combined with exercise therapy group (group A) and an exercise therapy group (group B), 32 cases in each one. In the group A, the relaxing needling manipulation was applied to the local painful area of knee or the stiff soft tissues. Additionally, the exercise therapy was used in combination. In the group B, the exercise therapy was applied simply. Hospital for special surgery (HSS) @entity1 score, the range of movement (ROM) of knee joint and Lysholm score were compared before and 60 days after treatment in the @entity0 of the two groups. The efficacy was compared between the two groups. RESULTS: After treatment, @entity1 score, ROM and Lysholm score were all improved in the two groups, presenting the significant differences as compared with those before treatment (all P<0. 05). The results in the group A were better than those in the group B (all P<0. 05). The total effective rate was 96. 9% (31/32) in the group A, which was better than 75. 0% (24/32) in the group B (P<0. 05). CONCLUSION: The combined therapeutic method of relaxing needling manipulation and exercise therapy achieves the significant efficacy on the motor impairment of knee joint after the operation for the @entity2 of femoral shaft, superior to the simple exercise therapy.

title: [Clinical research of knee joint motor impairment after XXXX operation treated with relaxing needling manipulation combined with exercise therapy].

answer: @entity2


abstract: - In this prospective study, baseline information regarding @entity1 to permanent teeth is presented. The aim of the study was twofold: to increase the knowledge of @entity2 in young Norwegians and to examine whether a rise in the number of dental @entity1 had occurred during the last 10-15 years. Both an urban and a rural area were included, constituting 12% of the 7-18-year-olds living in the country. A total of 1275 @entity0 in this age group suffered @entity2 in the capital city of Oslo and in the rural area of Nord-Tr  ndelag during a 1-year registration period. The @entity0 were examined by calibrated dentists in the public dental health service. The service offers regular, free recalls, and 98% of the @entity0 attend. The @entity2 were classified according to WHO's classification system. The dental @entity1 incidence found was 1.8% (2.0% in Oslo and 1.3% in Nord-Tr  ndelag). Nearly 50% of the @entity0 were in the age group 8-10 years. Ninety-seven per cent of the accidents involved the incisors, and the minor @entity1 dominated. Age and gender were predisposing factors. @entity0 were nearly twice as often injured as @entity0 and this difference increased with age. No increase in the annual frequency of @entity2 was observed.

title: XXXX in Norwegians aged 7-18 years.

answer: @entity2


abstract: UNASSIGNED: This retrospective study examined the longitudinal hospital outcomes (costs adjusted for inflation, hospital days, and admissions) associated with the treatment of pediatric, adolescent, and young adult @entity2 ( @entity2 ). @entity0 between one and 26  years of age with newly diagnosed @entity2 , who were treated at Primary @entity0 's Hospital (PCH) in Salt Lake City, Utah were included. Treatment and hospitalization data were retrieved from system-wide @entity1 registry and enterprise data warehouse. PCH is a member of the @entity0 's Oncology Group (COG) and @entity0 were treated on, or according to, active COG protocols. Treatment-related hospital costs of @entity2 were examined by computing the average annual growth rates (AAGR). Longitudinal regressions identified @entity0 characteristics associated with costs. A total of 505 @entity0 (46.9% female) were included. The majority of @entity0 had B-cell lineage @entity2 , 6.7% had @entity2 , and the median age at diagnosis was 4  years. Per- @entity0 , first-year @entity2 hospitalization costs at PCH rose from  24,197 in 1998 to  37,924 in 2012. The AAGRs were 6.1, 13.0, and 7.6% for total, pharmacy, and room and care costs, respectively. Average days (AAGR  =  5.2%) and admissions (AAGR  =  3.8%) also demonstrated an increasing trend. High-risk @entity0 had 47% higher costs per 6-month period in the first 5  years from diagnosis than standard-risk @entity0 (P  <  0.001). Similarly, relapsed @entity2 and stem cell transplantations were associated with significantly higher costs than nonrelapsed and no transplantations, respectively (P  <  0.001). Increasing treatment-related costs of @entity2 demonstrate an area for further investigation. Value-based interventions such as identifying low-risk fever and @entity3 @entity0 and managing them in outpatient settings should be evaluated for reducing the hospital burden of @entity2 .

title: A retrospective analysis of treatment-related hospitalization costs of pediatric, adolescent, and young adult XXXX .

answer: @entity2


abstract: OBJECTIVES: We evaluated fixation in high tibial osteotomy with the use of a @entity4 ( @entity4 ), together with its advantages. METHODS: Thirty-nine @entity0 (40 knees) underwent high tibial osteotomy for @entity1 and medial compartment degeneration. Fixation was performed by a @entity4 in which a semi-tubular plate and a long leg screw were used in place of the original Weber instrumentation. Thirty-five @entity0 were @entity0 and four were @entity0 , with a mean age of 52.5 years (range 25 to 67 years). The @entity0 were evaluated before surgery both clinically and by HSS scores and the advantages and disadvantages of the technique were assessed. The mean follow-up was 22 months (range 8 to 45 months). RESULTS: All @entity0 were allowed to give weight on the affected leg to the extent of utmost tolerability on the forth postoperative day. At the end of two weeks, 60% of the @entity0 could bear half of the body weight. Screw breakage occurred in one @entity0 due to faulty application of the technique. @entity3 was seen in none of the @entity0 , nor were there any early or late complications. Radiologic evidence of union was observed in all osteotomy sites. All @entity0 achieved full extension except two who had a @entity1 of 5 degrees. The mean knee flexion was 130.2 degrees. CONCLUSION: High tibial osteotomy may provide a rigid fixation, @entity2 and low complication rates in @entity1 and medial gonarthrosis of the knee. Our data suggest that @entity4 results in good stability both statically and dynamically in the fixation of high tibial osteotomy.

title: [The use of a XXXX for high tibial osteotomy].

answer: @entity4


abstract: UNASSIGNED: The FDA-approved schedule and dose of bevacizumab (BVZ) for recurrent @entity2 (rGB) (10  mg/kg q 2  weeks) were adopted from systemic @entity1 protocols. No dose-defining studies have been performed for @entity2 . We began using BVZ for the treatment of rGB in 2005 at the dose of 5  mg/kg every 2  weeks combined with @entity4 , and later as single agent. Our previous report of 20 @entity0 treated with BVZ 5  mg/kg every 2  weeks showed similar response rates and @entity3 ( @entity3 ) compared to other BVZ treatment protocols, with less adverse effects. In this study we retrospectively reviewed our 7 year experience with BVZ in 162 rGB @entity0 . Treatment outcomes were analyzed from 87 @entity0 who received BVZ at 5  mg/kg and 75 @entity0 at 10  mg/kg. While median age was similar in both groups, the median KPS was significantly higher in the group treated with 10  mg/kg BVZ (85 versus 60). There was no significant difference in @entity3 or progression free survival (PFS) between the groups treated with BVZ 5 versus 10  mg/kg. Overall survival was significantly improved in the subgroup treated with cytotoxic therapy in addition to BVZ 10  mg/kg. There were more adverse events seen with BVZ 10  mg/kg. There is no significant difference in @entity3 for rGB treated with BVZ 5  mg/kg versus 10  mg/kg when given as monotherapy. The smaller dose was slightly less toxic. Addition of cytotoxic therapy resulted in prolongation of @entity3 in a small subgroup of BVZ 10  mg/kg.

title: The optimal regimen of bevacizumab for recurrent XXXX : does dose matter?

answer: @entity2


abstract: UNASSIGNED: Aging is associated with development of @entity3 . Loss of B cell tolerance in the elderly is suggested by an increased prevalence of anti-nuclear antibodies (ANAs) and rheumatoid factors (RFs). Accumulating evidence indicates that B cells also impact @entity3 via secretion of cytokines. So far, few studies have directly assessed the effect of aging on the latter B cell function. Here, we determined if and how @entity0 aging influences the production of cytokines by B cells. In a cross-sectional study, we found that absolute numbers of circulating B cells were similar in 31 young (ages 19-39) and 73 old (age>= 60) individuals. Numbers of transitional B cells (CD19(+)CD27(-)CD38(High)CD24(High)) were decreased in old individuals, whereas numbers of naive and memory B cell subsets were comparable in young and old individuals. Short-term in vitro stimulation of whole blood samples revealed that numbers of B cells capable of producing @entity1 were similar in young and old individuals. In contrast, B cells capable of @entity2 production were decreased in old subjects. This decline of @entity4 cells was observed in old individuals that were ANA positive, and in those that were negative for both ANAs and RFs. However, @entity4 cells were remarkably well retained in the circulation of old subjects that were RF positive. Thus, pro-inflammatory @entity1 (+) B cells are retained in the elderly, whereas @entity4 cells generally decline. In addition, our findings indicate that @entity4 cells may differentially impact the development of ANAs and RFs in the elderly.

title: Aging-dependent decline of XXXX producing B cells coincides with production of antinuclear antibodies but not rheumatoid factors.

answer: @entity2


abstract: BACKGROUND: To investigate the immunohistochemical and clinicopathological behaviors of primary @entity7 ( @entity7 ). METHODS: A retrospective study of 10 cases of urinary tract SCC (7 @entity0 and 3 @entity0 , average age, 54; range, 35-78 years) at Chang Gung Memorial Hospital is reported. Among these cases, 3 @entity2 arose from the kidney, 2 from the renal pelvis, 2 from the ureter, and 3 from the bladder. Clinical and follow-up data were obtained. Histological and immunohistochemical studies with antibodies to neuroendocrine (NE) markers were conducted. RESULTS: The most prominent common feature of the 10 @entity7 was their cell histopathology: small to medium-sized round to spindle-shaped cells with scanty cytoplasm, hyperchromatic nuclei, and inconspicuous nucleoli. Immunostaining revealed positive @entity6 ( @entity6 ) reactivity in 10 of 10 @entity2 , but there was focal and weak staining for @entity5 ( @entity5 ) in 4 of 10 @entity2 . The 7 @entity0 with @entity4 -positive @entity7 all developed metastatic lesions, and 5 of them expired within 1 year. CONCLUSIONS: @entity7 of the urinary tract system share similar histopathological features and NE markers with their pulmonary counterpart. @entity6 was expressed more consistently than @entity5 in these @entity2 . However, the preferential expression of @entity6 and intensity of immunostaining of these 2 NE markers did not predict the clinical outcome of these @entity0 . The presence of both @entity3 or SCC alone did not foretell the clinical outcome either. @entity0 with the presence of @entity4 in the @entity2 tissues appeared to have poorer prognoses with early @entity1 and mortality.

title: A retrospective immunohistochemical and clinicopathological study of XXXX of the urinary tract.

answer: @entity7


abstract: A clinical study was carried out in 80 eyes of 50 @entity1 @entity0 with significant capillary nonperfusion at least in one eye. Panoramic photography of the fundus and wide-angle composite @entity3 angiography was performed in all cases. Forty-nine @entity0 had @entity5 . The mean age of the @entity0 was 60 years and the mean duration of @entity1 was 12.1 years; 46% of the @entity0 had @entity2 . @entity6 were observed in the iris sphincter in 20% of eyes. In addition, abnormal leakage of dye was observed in these eyes. Abnormal leakage of dye from the iris vessels was also observed in 9 of 20 eyes without clinically visible neovascularization. Numerous soft exudates distributed in a semicircular arc pattern were observed in 49% of eyes. Soft exudates were isolated and scarce in 37% of cases and were completely absent in 14% of eyes. Thus, in a substantial proportion of cases, the severity of the @entity4 could not be assessed by ophthalmoscopic findings alone.

title: Nonproliferative XXXX with significant capillary nonperfusion.

answer: @entity1


abstract: Anesthetic management of a parturient with @entity5 associated with hemoptysis, @entity4 , and orthopnea is difficult. An anesthesiologist should realize that the @entity0 ' @entity7 problem is not solved during the surgery. This circumstance is similar to a @entity0 with associated @entity2 scheduled for non-cardiac surgery. General anesthesia with endotracheal intubation can provide safe oxygenation for both the parturient and the fetus, but with possible unexpected massive hemoptysis and @entity1 seeding. Prolonged intubation may delay the @entity0 's pulmonary treatment course. Laryngeal mask anesthesia can provide an airway, but must not be secured due to the risk of @entity3 . The need of high doses of inhalation drugs may hinder uterine contractions. The addition of a muscle relaxant will change the @entity0 's respiratory patterns and physiology. Regional anesthesia alone might not be tolerated. A decrease in cough strength, as well as @entity4 , orthopnea, and hyperventilation may be harmful to both the parturient and the fetus. However, we successfully managed this case using epidural anesthesia combined with assisted mask ventilation instead of spontaneous breathing usually provided by a simple mask in almost all American Society of Anesthesiology (ASA) class I-II parturients during cesarean section. The anesthetic level was maintained at T8 with 18 ml of 2% Xylocaine mixed with 2 ml of 7% @entity6 with 1:200,000 epinephrine epidurally and with the @entity0 in a supine position with the head up at 30 degrees to prevent cephalic spreading and to ensure better pulmonary ventilation.

title: Anesthetic management of a parturient undergoing cesarean section with a XXXX and hemoptysis.

answer: @entity1


abstract: BACKGROUND: Recent literature suggests that focus in health care should shift from reducing costs to improving quality; where quality of health care improves, @entity2 will follow. Our primary aim was to investigate whether improving the quality of surgical @entity1 care, by using a national quality improvement initiative, leads to a reduction of hospital costs. STUDY DESIGN: This was a retrospective analysis of clinical and financial outcomes after @entity1 surgery in 29 Dutch hospitals (9,913 @entity0 ). Detailed clinical data were obtained from the 2010 to 2012 population-based Dutch Surgical Colorectal Audit. @entity0 -level costs were measured uniformly in all participating hospitals and based on time-driven, activity-based costing. Odds ratios (OR) and relative differences (RD) were risk adjusted for hospitals and differences in @entity0 characteristics. RESULTS: Over 3 consecutive years, severe complications and mortality declined by 20% (risk-adjusted OR 0.739, 95% CI 0.653 to 0.836, p < 0.001), and 29% (risk-adjusted OR 0.757, 95% CI 0.571 to 1.003, p  = 0.05), respectively. Simultaneously, costs during primary admission decreased 9% (risk-adjusted RD  -7%, 95% CI  -10% to  -5%, p  <  0.001) without an increase in costs within the first 90 days after discharge (RD  -2%, 95% CI  -10% to 6%, p  =  0.65). An inverse relationship (at hospital level) between severe complication rate and hospital costs was identified (R  = 0.64). Hospitals with increasing severe complication rates (between 2010 and 2012) were associated with increasing costs; hospitals with declining severe complication rates were associated with @entity2 . CONCLUSIONS: This report presents evidence for simultaneous quality improvement and @entity2 . Participation in a nationwide quality improvement initiative with continuous quality measurement and benchmarked feedback reveals opportunities for targeted improvements, bringing the medical field forward in improving value of health care delivery. The focus of health care should shift to improving quality, which will catalyze costs savings as well.

title: Nationwide Outcomes Measurement in XXXX Surgery: Improving Quality and Reducing Costs.

answer: @entity1


abstract: We have investigated the role of @entity4 -derived heat shock protein 70 (TgHSP70) as a B cell mitogen by measuring proliferative responses in vitro. TgHSP70 induced prominent proliferative responses in @entity0 B cells derived not only from @entity4 -infected but also from uninfected @entity0 . @entity0 responded to TgHSP70; however, severe @entity1 , RAG1-/- B6, and microMT @entity0 failed to respond. B220+ spleen cells showed marked proliferation after stimulation with TgHSP70, but neither @entity2 + nor CD8+ population responded. This unresponsiveness of @entity2 + and CD8- T cells to TgHSP70 was antigen presenting cells independent. These data indicate that TgHSP70 induced the proliferation of B cells but not T cells. @entity6 , a potent inhibitor of lipopolysaccharide (LPS), did not eliminate TgHSP70-induced proliferation. C3H/HeN @entity0 responded well to TgHSP70 stimulation; however, C3H/HeJ @entity0 carrying a point mutation in the Toll-like receptor (TLR) 4 failed to respond. This indicates that @entity3 is required for TgHSP70-induced B cell activation. The involvement of @entity3 in the TgHSP70-induced proliferative responses of spleen cells was also shown by the use of @entity3 -/- @entity0 . But TgHSP70-induced, but not LPS-induced, spleen cell proliferation was observed in @entity5 -/- @entity0 , indicating that the @entity5 molecule was involved in LPS-induced proliferation but not in TgHSP70-induced proliferation.

title: XXXX -derived heat shock protein HSP70 functions as a B cell mitogen.

answer: @entity4


abstract: BACKGROUND: Cell-free fetal DNA analysis is used as a screening test to identify pregnancies that are at risk for common @entity5 . OBJECTIVE: The purpose of this study was to investigate the @entity3 that would not be detected by cell-free fetal DNA in a single medical center. STUDY DESIGN: This was a retrospective cohort analysis of 3182 consecutive invasive diagnostic procedures that were performed at Montefiore Medical Center's Division of Reproductive and Medical Genetics from January 1, 2009 to August 31, 2014. All @entity0 underwent cytogenetic analysis; one-third of the @entity0 (1037/3182) went through chromosomal microarray analysis. RESULTS: Clinically significant @entity3 were detected in 220 of 3140 cases (7%) after we excluded @entity4 pregnancies (n  = 42). Of these 125 cases (57%) were diagnosed with the common autosomal trisomies that involved chromosomes 21, 18, and 13 and with sex chromosome @entity2 . There were 23 mosaic karyotypes; 8 of them involved trisomy in chromosomes 21 and 13; 5 of them were sex chromosome mosaics, and 10 of them were other mosaic cases. Five cases of triploidy were detected. Additionally, 19 unbalanced chromosomal rearrangements, a rare autosomal trisomy, and 47 clinically significant findings on chromosomal microarray analysis were diagnosed. Based on the published detection rates of cell-free fetal DNA testing and considering the "no-results" rate, we calculated that 99 of 220 chromosomal changes (45%) could not have been detected by cell-free fetal DNA testing: 16 of the 125 common @entity2 and sex chromosome @entity2 , 1 of the 5 triploidy cases, 15 of the 23 mosaic cases, all cases of unbalanced chromosomal rearrangements (n  = 19), rare autosomal trisomy (n  = 1), and 47 clinically significant chromosomal @entity1 . CONCLUSIONS: Current cell-free DNA testing could not detect up to one-half of the clinically significant @entity3 that were found, which included clinically significant chromosomal @entity1 . Among the 99 abnormal karyotypes that were not identified by cell-free DNA screening, 79% were from @entity0 with abnormal screening or abnormal ultrasound finding; 21% were from @entity0 who underwent invasive testing simply for advanced maternal age/concern, with no other risk factors or ultrasound findings. This information highlights the limitations of cell-free DNA screening and the importance of counseling @entity0 about all prenatal screening and diagnostic procedures and about the added gain of invasive testing with karyotype and microarray.

title: XXXX not currently detected by cell-free fetal DNA: a retrospective analysis at a single center.

answer: @entity3


abstract: Eight cases with @entity0 anterior communicating @entity1 , who developed mental signs of mild degree lasting more than two weeks following direct operation, were subjected to our study. The following results were obtained. The mental signs of mild degree in 8 cases consisted of @entity4 . The main findings of CT scan was low density area in the subcortical and cortical areas of the frontal lobe. There was no close correlation on CT findings between @entity4 . Abnormal density areas were detected on CT scan, but EEG showed no localized abnormalities of slow waves. Abnormal density areas were not clearly shown on CT, but EEG showed localized abnormalities. Background activities on EEG were favorable despite lesions detected on CT. Either local or diffuse abnormalities were observed in EEG background activities while no abnormal mental signs were recognized. In cases with no apparent abnormal findings on CT and with favorable background activities on EEG, EEG showed marked build up during hyperventilation. As indicated by the above data, comparative studies of CT and EEG findings revealed differences in sites of @entity3 . This is considered caused by a possible increase in cerebral blood flow and metabolism at initiation of chronic stage following @entity2 -resulting in the disappearance of abnormalities on EEG.

title: [A comparative study of clinical signs, computed tomography, and electroencephalography after direct operation of XXXX anterior communicating @entity1 --Part I: Analysis of the cases with mental signs of mild degree].

answer: @entity0


abstract: Eight cases with @entity0 anterior communicating @entity1 , who developed mental signs of mild degree lasting more than two weeks following direct operation, were subjected to our study. The following results were obtained. The mental signs of mild degree in 8 cases consisted of @entity4 . The main findings of CT scan was low density area in the subcortical and cortical areas of the frontal lobe. There was no close correlation on CT findings between @entity4 . Abnormal density areas were detected on CT scan, but EEG showed no localized abnormalities of slow waves. Abnormal density areas were not clearly shown on CT, but EEG showed localized abnormalities. Background activities on EEG were favorable despite lesions detected on CT. Either local or diffuse abnormalities were observed in EEG background activities while no abnormal mental signs were recognized. In cases with no apparent abnormal findings on CT and with favorable background activities on EEG, EEG showed marked build up during hyperventilation. As indicated by the above data, comparative studies of CT and EEG findings revealed differences in sites of @entity3 . This is considered caused by a possible increase in cerebral blood flow and metabolism at initiation of chronic stage following @entity2 -resulting in the disappearance of abnormalities on EEG.

title: [A comparative study of clinical signs, computed tomography, and electroencephalography after direct operation of @entity0 anterior communicating XXXX --Part I: Analysis of the cases with mental signs of mild degree].

answer: @entity1


abstract: BACKGROUND: Around 27,000 new cases of @entity4 are diagnosed every year in Spain and 5400 die from this disease. Radiotherapy (RT), alone or combined, has proven to be effective as initial treatment in @entity0 with @entity2 . Our objective was to evaluate the use of external beam RT (EBRT) in our region, comparing the indication rate and irradiation rate and examining variability in its application among hospitals. METHODS: We conducted a review of RT guidelines and indication studies for @entity4 (% expected irradiation). Data were gathered from all twelve public healthcare centers in Andalusia (Spain) on RT-treated @entity4 @entity0 during 2013 (% actual irradiation) and from nine of the centers on RT discharge reports. Information was classified according to type of hospital, @entity1 risk category and RT treatment (technique, dosage, volume, @entity3 ). RESULTS: The estimated RT rate was 67  % (1289/1917), 43  % were aged   >   70  years, 44.7  % had ECOG performance status of 0); 44.7  % had high-risk @entity1 ; 57  % underwent RT associated with hormone therapy; 70  % of @entity0 receiving RT were treated with 3D planning (30  % IGRT); and doses were 70-76  Gy in 70  % of cases and >76  Gy in 10.7  %. Acute @entity5 were   <   grade 2 in 79 and 89  % of @entity0 , respectively. An irradiation rate significantly below the mean for the study was found in four provinces. There was a significant difference among provinces in the distribution of risk groups. CONCLUSIONS: Underutilization of EBRT was estimated to be around 30  % in @entity4 @entity0 , with an elevated variability in irradiation rates among hospitals related to differences in available technology and in the distribution of @entity0 with different risk levels. These data should be a matter of concern to regional health managers, given the negative and measurable impact on the survival of @entity0 .

title: Evaluation of the utilization of external radiotherapy in the treatment of XXXX in Andalusia, Spain.

answer: @entity4


abstract: UNASSIGNED: @entity0 is the most common @entity2 with high morbidity and mortality among @entity1 worldwide. Aberrant hypermethylation in promoter regions of the @entity2 suppressor genes such as @entity3 gene is a key event in the progression and development of @entity0 . The aim of the present study was to evaluate an association between @entity3 gene methylation status with the risk of @entity0 in an Iranian population. We studied 255 individuals, including 103 @entity1 with @entity0 , 102 first-degree female relatives of @entity1 (mother, sister, or daughter of @entity1 ), and 50 healthy individuals as a control group. Genomic DNA was extracted from peripheral blood leukocytes, and the @entity3 promoter methylation status was detected using methylation-specific PCR (MSP) method with specific methylated and unmethylated primers. In some samples, direct DNA sequencing was used to confirm the results obtained by the MSP method. The frequency of @entity3 -methylated (MM) genotype was 6  % in the healthy control group, 23.3  % in relatives of @entity1 , and 41.7  % in @entity1 (   (2)   =   24.62, p   <   0.001). There were significant differences in the frequency of @entity3 -methylated genotype between healthy control compared to that in @entity1 (   (2)   =   15.1, p   <   0.001) and also compared to that in relatives of @entity1 (   (2)   =   6.9, p   =   0.009). In the presence of @entity3 MM genotype, there was a 3.1-fold susceptibility to @entity0 compared to the UU genotype (p   <   0.001). Also, in the presence of @entity3 M allele, the risk of @entity0 was 2.71-fold compared to the presence of U allele (p   <   0.001). Our findings indicated increased frequency of hypermethylation of @entity3 promoter in the studied @entity1 and their relatives that could be considered as one of the epigenetic factors affecting the risk of @entity0 in Iranians.

title: Association of the hypermethylation status of @entity3 XXXX suppressor gene with the risk of @entity0 among Kurdish population from Western Iran.

answer: @entity2


abstract: UNASSIGNED: @entity0 is the most common @entity2 with high morbidity and mortality among @entity1 worldwide. Aberrant hypermethylation in promoter regions of the @entity2 suppressor genes such as @entity3 gene is a key event in the progression and development of @entity0 . The aim of the present study was to evaluate an association between @entity3 gene methylation status with the risk of @entity0 in an Iranian population. We studied 255 individuals, including 103 @entity1 with @entity0 , 102 first-degree female relatives of @entity1 (mother, sister, or daughter of @entity1 ), and 50 healthy individuals as a control group. Genomic DNA was extracted from peripheral blood leukocytes, and the @entity3 promoter methylation status was detected using methylation-specific PCR (MSP) method with specific methylated and unmethylated primers. In some samples, direct DNA sequencing was used to confirm the results obtained by the MSP method. The frequency of @entity3 -methylated (MM) genotype was 6  % in the healthy control group, 23.3  % in relatives of @entity1 , and 41.7  % in @entity1 (   (2)   =   24.62, p   <   0.001). There were significant differences in the frequency of @entity3 -methylated genotype between healthy control compared to that in @entity1 (   (2)   =   15.1, p   <   0.001) and also compared to that in relatives of @entity1 (   (2)   =   6.9, p   =   0.009). In the presence of @entity3 MM genotype, there was a 3.1-fold susceptibility to @entity0 compared to the UU genotype (p   <   0.001). Also, in the presence of @entity3 M allele, the risk of @entity0 was 2.71-fold compared to the presence of U allele (p   <   0.001). Our findings indicated increased frequency of hypermethylation of @entity3 promoter in the studied @entity1 and their relatives that could be considered as one of the epigenetic factors affecting the risk of @entity0 in Iranians.

title: Association of the hypermethylation status of @entity3 @entity2 suppressor gene with the risk of XXXX among Kurdish population from Western Iran.

answer: @entity0


abstract: UNASSIGNED: @entity0 is the most common @entity2 with high morbidity and mortality among @entity1 worldwide. Aberrant hypermethylation in promoter regions of the @entity2 suppressor genes such as @entity3 gene is a key event in the progression and development of @entity0 . The aim of the present study was to evaluate an association between @entity3 gene methylation status with the risk of @entity0 in an Iranian population. We studied 255 individuals, including 103 @entity1 with @entity0 , 102 first-degree female relatives of @entity1 (mother, sister, or daughter of @entity1 ), and 50 healthy individuals as a control group. Genomic DNA was extracted from peripheral blood leukocytes, and the @entity3 promoter methylation status was detected using methylation-specific PCR (MSP) method with specific methylated and unmethylated primers. In some samples, direct DNA sequencing was used to confirm the results obtained by the MSP method. The frequency of @entity3 -methylated (MM) genotype was 6  % in the healthy control group, 23.3  % in relatives of @entity1 , and 41.7  % in @entity1 (   (2)   =   24.62, p   <   0.001). There were significant differences in the frequency of @entity3 -methylated genotype between healthy control compared to that in @entity1 (   (2)   =   15.1, p   <   0.001) and also compared to that in relatives of @entity1 (   (2)   =   6.9, p   =   0.009). In the presence of @entity3 MM genotype, there was a 3.1-fold susceptibility to @entity0 compared to the UU genotype (p   <   0.001). Also, in the presence of @entity3 M allele, the risk of @entity0 was 2.71-fold compared to the presence of U allele (p   <   0.001). Our findings indicated increased frequency of hypermethylation of @entity3 promoter in the studied @entity1 and their relatives that could be considered as one of the epigenetic factors affecting the risk of @entity0 in Iranians.

title: Association of the hypermethylation status of XXXX @entity2 suppressor gene with the risk of @entity0 among Kurdish population from Western Iran.

answer: @entity3


abstract: Over the last several years, low-dimensional @entity1 derivatives, such as @entity0 nanotubes and @entity1 nanoribbons, have played a central role in the pursuit of a plausible @entity0 -based nanotechnology. Their electronic properties can be either metallic or semiconducting depending purely on morphology, but predicting their electronic behavior has proven challenging. The combination of experimental efforts with modeling of these nanometer-scale structures has been instrumental in gaining insight into their physical and chemical properties and the processes involved at these scales. Particularly, approximations based on density functional theory have emerged as a successful computational tool for predicting the electronic structure of these materials. In this Account, we review our efforts in modeling graphitic nanostructures from first principles with hybrid density functionals, namely the Heyd-Scuseria-Ernzerhof (HSE) screened exchange hybrid and the hybrid meta-generalized functional of Tao, Perdew, Staroverov, and Scuseria (TPSSh). These functionals provide a powerful tool for quantitatively studying structure-property relations and the effects of external perturbations such as chemical substitutions, electric and magnetic fields, and mechanical deformations on the electronic and magnetic properties of these low-dimensional @entity0 materials. We show how HSE and TPSSh successfully predict the electronic properties of these materials, providing a good description of their band structure and density of states, their work function, and their magnetic ordering in the cases in which magnetism arises. Moreover, these approximations are capable of successfully predicting optical transitions (first and higher order) in both metallic and semiconducting single-walled @entity0 nanotubes of various chiralities and diameters with impressive accuracy. This versatility includes the correct prediction of the trigonal warping splitting in metallic nanotubes. The results predicted by HSE and TPSSh provide excellent agreement with existing photoluminescence and Rayleigh scattering spectroscopy experiments and Green's function-based methods for @entity0 nanotubes. This same methodology was utilized to predict the properties of other @entity0 nanomaterials, such as @entity1 nanoribbons. @entity1 nanoribbons may be viewed as unrolled (and passivated) @entity0 nanotubes. However, the emergence of edges has a crucial impact on the electronic properties of @entity1 nanoribbons. Our calculations have shown that armchair nanoribbons are predicted to be nonmagnetic semiconductors with a band gap that oscillates with their width. In contrast, zigzag @entity1 nanoribbons are semiconducting with an electronic ground state that exhibits spin polarization localized at the edges of the @entity0 nanoribbon. The spatial symmetry of these magnetic states in @entity1 nanoribbons can give rise to a half-metallic behavior when a transverse external electric field is applied. Our work shows that these properties are enhanced upon different types of oxidation of the edges. We also discuss the properties of rectangular @entity1 flakes, which present spin polarization localized at the zigzag edges.

title: Accurate prediction of the electronic properties of low-dimensional XXXX derivatives using a screened hybrid density functional.

answer: @entity1


abstract: OBJECTIVES: Success in reaching target populations is an important factor in determining the impact of public health programmes. The @entity3 Health Check (NHSHC) Programme is directed towards reducing excess cardiovascular mortality in England. As the programme is locally commissioned, local monitoring of programme reach is essential. This study aimed to assess indicators of programme reach available to local service commissioners. STUDY DESIGN: Ecological. METHODS: The programme reach of NHSHC was assessed in three health districts in the North East of England. Local data returned from GP practices to commissioners on their NHSHC activities was collated for the period October 2010 to March 2013 together with related national published data. Three candidate indicators were chosen and the association between each of these and NHSHCs at GP practice level was examined by univariate logistic regression. RESULTS: Data were available from 101  GP practices, together undertaking almost 20,000 health checks a year. Number of NHSHCs by practices explained most (77-92%) of the variance the numbers identified at high risk of @entity1 (two for every ten NHSHCs). NHSHCs were not associated with growth in GP practice disease registers for either @entity0 or @entity2 . NHSCHs predicted practices identification of new cases of @entity2 (with one case identified for every ten checks), albeit the proportion of variation explained was much more variable (2-60%) less consistent effect. CONCLUSIONS: Data routinely available to NHSHC commissioners can support monitoring programme reach, with numbers of new cases of @entity2 being the most promising indicator of reach.

title: Assessing potential local routine monitoring indicators of reach for the XXXX health checks programme.

answer: @entity3


abstract: OBJECTIVE: We estimated the prevalence, incidence and risk factors of @entity5 ( @entity5 ) in a prospective cohort study of 26 489 @entity0 . MATERIAL AND METHODS: The @entity5 was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was defined as a prevalence case and those who developed it between subsequent visits were incidence cases. The comparison cohort were all other @entity0 in the Reykjavik Study stages I-V. RESULTS: A total of 297 @entity0 and 49 @entity0 were found to have @entity5 of 3.2% and 0.5%, respectively. The incidence was 25 per 1000 per year amongst @entity0 and six per 1000 per year amongst @entity0 . Prevalence in both genders increased with increasing age. Risk factors at the time of diagnosis were systolic blood pressure [odds ratio (OR) per mmHg 1.02; 95% confidence interval (CI): 1.01-1.03], age (OR per year 1.04; 95% CI: 1.02-1.05), silent @entity2 ( @entity2 ) (OR 3.18; 95% CI: 1.39-7.27) and @entity4 changes (OR 3.06; 95% CI: 2.14-4.38) amongst @entity0 and systolic blood pressure and age for @entity0 with similar odds ratio. Predictive factors for acquiring @entity5 were systolic blood pressure [incidence ratio (IR) 1.01; 95% CI: 1.01-1.02] and angina with ECG changes (IR 2.33; 95% CI: 1.08-5.02) amongst @entity0 and systolic blood pressure amongst @entity0 ( @entity6 .03; 95% CI: 1.01-1.04). The risk for coronary mortality was significantly increased amongst @entity0 with @entity3 [hazard ratio (HR) 3.07; 95% CI: 1.5-6.31] and their total survival was poorer with increasing time from diagnosis of @entity5 (HR 2.17; 95% CI: 1.36-3.48). CONCLUSIONS: We conclude that the presence of @entity5 and its appearance is associated with age and increased blood pressure amongst both genders. @entity0 with @entity5 have poorer survival than other @entity0 and they are at threefold risk of dying of @entity1 .

title: Survival and trends of occurrence of XXXX , gender differences, 1967-92: The Reykjavik Study.

answer: @entity5


abstract: Mortality rates in the United States from @entity1 are higher among blacks than whites at younger ages, with a crossover to lower rates above the age of 70. The factors that determine this crossover of age-specific death rates have not been elucidated. Selection from the black population of younger individuals who are sicker by virtue of being more coronary prone might leave a relatively healthier group of older @entity0 . Support for this hypothesis would consist in part of evidence that @entity1 has an earlier onset in the black population. We examined data from the National Hospital Discharge Survey for the years 1973-1984 to determine if age-related differences in case-fatality rates existed between whites and nonwhites. In-hospital case fatality rates were 10% to 70% higher for each of the 10 year age groups for nonwhites up to age 70, at which time a crossover occurred. The median age at death from @entity2 was approximately 5 years younger in nonwhites compared with whites. National estimates of hospitalization rates for @entity2 from these data likewise suggest that nonwhites receive less health care for @entity1 than whites relative to recorded fatal events. The age-specific trends in case-fatality support the hypothesis that a cohort selection effect in part determines the black/white differentials in @entity1 . Relative susceptibility of the black and white population is thus not appropriately estimated by age-adjusted rates, but should be examined on an age-specific basis within the framework of selection effects on a cohort.

title: In-hospital mortality rates from acute XXXX by race in U.S. hospitals: findings from the National Hospital Discharge Survey.

answer: @entity2


abstract: BACKGROUND: Intravenous unfractionated heparin remains a cornerstone of anticoagulation therapy for @entity0 with @entity3 , but regulation to a target aPTT is challenging. We assessed unfractionated heparin infusion regulation by bedside, whole-blood aPTT testing and computerized, algorithmic infusion adjustment, and further evaluated the relationship of achieving the target aPTT with clinical outcomes. METHODS AND RESULTS: We studied 1,275 @entity0 randomized to unfractionated heparin in PARAGON-A, which tested lamifiban with or without unfractionated heparin versus unfractionated heparin. All @entity0 had baseline and 6-hour blinded, bedside aPTTs, then aPTTs per algorithm. A central computer translated encrypted values to algorithmic dose-adjustment commands. We assessed the ability to achieve and maintain aPTTs of 50-70 seconds and associations of 6- and 12-hour aPTTs and time-to-target with 30-day outcomes.Overall, the median 6-hour aPTT was 50-70 seconds and remained so throughout infusion. Individually, only 33.6% of @entity0 achieved 6-hour target-range aPTTs, and only 40% of all aPTTs were in-range. After achieving target, only 42% of subsequent measures were in-range. Thirty-day @entity1 or @entity2 ( @entity1 /MI) increased non-significantly as time-to-target increased (p = 0.08). Thirty-day mortality was similar if target aPTT was reached, regardless of timing. @entity1 /MI trended lower if target aPTT was reached by 8 hours (p = 0.10). The best clinical outcomes were associated with in-range aPTTs. CONCLUSIONS: This study represents the most systematic monitoring and regulation of unfractionated heparin anticoagulation to date. Although average anticoagulation achieved target range, wide inter- and intra- @entity0 variability may have important implications for clinical outcomes.

title: An automated strategy for bedside aPTT determination and unfractionated heparin infusion adjustment in XXXX : insights from PARAGON A.

answer: @entity3


abstract: BACKGROUND: @entity0 ( @entity0 ) is one of the most common @entity0 in the western world. @entity0 cases are stratified into three histological grades based on the average centroblast count per @entity3 ( @entity3 ). The centroblast count is performed manually by the pathologist using an optical microscope and @entity1 and @entity2 (H_E) stained tissue section. Although this is the current clinical practice, it suffers from high inter- and intra-observer variability and is vulnerable to sampling bias. METHODS: In this paper, we present a system, called @entity5 ( @entity5 ), to assist the pathologist in grading @entity0 cases. We also assess the effect of @entity5 on accuracy of expert and inexperienced readers. @entity5 automatically identifies possible HPFs for examination by analyzing H_E and @entity4 stains, before classifying them into low or high risk categories. The pathologist is first asked to review the slides according to the current routine clinical practice, before being presented with @entity5 classification via color-coded map. The accuracy of the readers with and without @entity5 assistance is measured. RESULTS: @entity5 was used by four experts (board-certified hematopathologists) and seven pathology residents on 20 @entity0 slides. Access to @entity5 improved overall reader accuracy with the biggest improvement seen among residents. An average AUC value of 0.75 was observed which generally indicates "acceptable" diagnostic performance. CONCLUSIONS: The results of this study show that @entity5 can be useful in increasing the pathologists' accuracy in grading the tissue. To the best of our knowledge, this study measure, for the first time, the effect of computerized image analysis on pathologists' grading of @entity0 . When fully developed, such systems have the potential to reduce sampling bias by examining an increased proportion of HPFs within follicle regions, as well as to reduce inter- and intra-reader variability.

title: Classification of XXXX : the effect of computer aid on pathologists grading.

answer: @entity0


abstract: Hemodynamic and humoral responses to tilting were examined in order to elucidate the autonomic nervous function in @entity1 @entity0 . Eleven @entity1 ( @entity6 ) and eleven non- @entity1 (non- @entity6 ) @entity0 on maintenance hemodialysis treatment were involved in the experimentation, matching the age and the duration of hemodialysis. Cardiac output, blood pressure, plasma @entity3 activity (PRA), @entity4 (NE) and @entity5 (EP) were measured before and 5 minutes after the 45 degree tilting. By the tilting the blood pressure significantly fell in @entity6 , whereas it rose slightly but significantly in non- @entity6 . In both groups, however, the heart rate remained unchanged, and either cardiac index or @entity2 volume index decreased equally. The percentile increase in total peripheral resistance index (TPRI) was significantly smaller in @entity6 (14.6%) than in non- @entity6 (27.9%). There was a significant correlation between the changes in TPRI and diastolic blood pressure (r = 0.730, p less than 0.01). NE and EP increased significantly in non- @entity6 but not in @entity6 . Blood pressure reduced by the tilting in @entity6 was associated with a small or equivocal response in either TPRI or plasma NE. The heart rate did not respond to the tilting in both groups. These results indicate that both sympathetic and parasympathetic nervous systems are deranged in @entity1 @entity0 but parasympathetic dysfunction is evident even in non- @entity1 @entity0 .

title: The hemodynamic and humoral responses to tilting in XXXX @entity0 on chronic hemodialysis treatment.

answer: @entity1


abstract: Hemodynamic and humoral responses to tilting were examined in order to elucidate the autonomic nervous function in @entity1 @entity0 . Eleven @entity1 ( @entity6 ) and eleven non- @entity1 (non- @entity6 ) @entity0 on maintenance hemodialysis treatment were involved in the experimentation, matching the age and the duration of hemodialysis. Cardiac output, blood pressure, plasma @entity3 activity (PRA), @entity4 (NE) and @entity5 (EP) were measured before and 5 minutes after the 45 degree tilting. By the tilting the blood pressure significantly fell in @entity6 , whereas it rose slightly but significantly in non- @entity6 . In both groups, however, the heart rate remained unchanged, and either cardiac index or @entity2 volume index decreased equally. The percentile increase in total peripheral resistance index (TPRI) was significantly smaller in @entity6 (14.6%) than in non- @entity6 (27.9%). There was a significant correlation between the changes in TPRI and diastolic blood pressure (r = 0.730, p less than 0.01). NE and EP increased significantly in non- @entity6 but not in @entity6 . Blood pressure reduced by the tilting in @entity6 was associated with a small or equivocal response in either TPRI or plasma NE. The heart rate did not respond to the tilting in both groups. These results indicate that both sympathetic and parasympathetic nervous systems are deranged in @entity1 @entity0 but parasympathetic dysfunction is evident even in non- @entity1 @entity0 .

title: The hemodynamic and humoral responses to tilting in @entity1 XXXX on chronic hemodialysis treatment.

answer: @entity0


abstract: OBJECTIVES: We evaluated the radiological and clinical results of complete subtalar release in @entity0 with @entity2 . METHODS: We performed complete subtalar release in 30 feet of 20 @entity0 (14 @entity0 , 6 @entity0 ; mean age 8 months; range 3.5 to 18.5 months). We employed the Cincinnati incision in all cases. The results were evaluated according to the Simon's clinical and radiological criteria. Tarsal bone problems were analyzed separately. The mean follow-up period was 24.6 months (range 12 to 41 months). RESULTS: Clinical results were satisfactory in 24 feet (80%) and unsatisfactory in six feet (20%). Radiologically, satisfactory and unsatisfactory results were encountered in 19 feet (63%) and 11 feet (37%), respectively. Undercorrection occurred in 13 feet (43.3%) and overcorrection in one foot (1.4%). Revision surgery which was recommended for five undercorrected feet (16.6%) with unsatisfactory clinical and radiological results could be performed in four feet (13.3%). Deep @entity1 that occurred in two feet (one with @entity1 ) was treated surgically. Superficial @entity1 developed in five feet and soft tissue infection in one feet, all of which responded well to conservative treatment. Other complications included @entity3 and @entity4 in two feet, respectively. CONCLUSION: Complete subtalar release allows to correct all components of @entity2 in a single session. The results may appreciably be improved with enhanced surgical experience.

title: [Early results of complete subtalar release in XXXX ].

answer: @entity2