abstract: PURPOSE: To explore @entity1 survivors' perspectives of two novel models of inpatient physiotherapy, which provide an increased amount of therapy: five days a week circuit class therapy and seven days a week individual therapy. METHOD: This is a qualitative descriptive study using semi-structured interviews and thematic analysis. The @entity0 were 10 purposively sampled @entity1 survivors in the post-acute phase of recovery, who had experienced seven days a week individual therapy or five days a week circuit group therapy during inpatient rehabilitation. RESULTS: Three main themes emerged from the data: Too much, too little or just right; My experience - alone and together; and Meeting my needs. Findings revealed considerable variety in @entity0 ' beliefs, priorities and preferences regarding how intensely they could work; their experience of success and challenge individually and collectively; and their need to have their own unique individual needs met. Lack of choice seemed to be a linking concept between the themes. CONCLUSION: In order to provide @entity0 -centred services, novel methods of increased therapy must take into consideration the individual needs and preferences of the @entity0 accessing them. One model may not meet all these needs, hence a "menu" of options for therapy sessions (different timing, frequency, duration, content, rest and supervision) may be required to accommodate the diversity of @entity0 needs, preferences and capacities. Implications for Rehabilitation @entity0 with @entity1 have diverse needs and preferences regarding the modes of delivering more therapy during rehabilitation. These diverse needs may not be met by one rigid service model. Therapists and service providers could engage their clients in a dialogue about the need for more therapy and how it can be delivered. This dialogue could include options of the various ways to increase their therapy. Therapists need to provide clear reasons and education around therapy components, including rest time and practice schedules.

title: XXXX survivors' perspectives on two novel models of inpatient rehabilitation: seven-day a week individual therapy or five-day a week circuit class therapy.

answer: @entity1


abstract: UNASSIGNED: Tooth @entity3 and @entity1 are two totally different diseases occurring at different ages. In the past ten years, more and more evidences suggested there was a relationship between them. High prevalence of breast, @entity2 was observed in tooth @entity3 @entity0 . But it is still controversial. Therefore, to have a greater understanding of the possible association, a critical review on molecular association for genes involving tooth @entity3 and tumorigenesis is necessary. In this current review, we summarized the reported cases of tooth @entity3 with different kinds of @entity1 and the molecular relationship between these two diseases through causative genes. The results indicated tooth @entity3 might be a prospective predictive marker for @entity1 . Through this review, we want to draw more attention on this topic and hope it will be an effective way to predict the risk of @entity1 . This article is protected by copyright. All rights reserved.

title: Hypodontia, a prospective predictive marker for XXXX ?

answer: @entity1


abstract: BACKGROUND AND AIM OF THE STUDY: @entity5 ( @entity5 ) represents a significant challenge in mitral valve (MV) surgery. Techniques to decalcify the mitral annulus significantly increase operative complexity and risk. MV repair can be particularly difficult in this setting. Mid-term outcomes following MV surgery with extensive @entity8 were examined, with attention focused on the feasibility and outcomes of MV repair in this setting. METHODS: Among 1,485 @entity0 undergoing MV surgery between 1999 and 2008 at the authors' institutions, 24 (1.6%) underwent complete posterior MV @entity8 associated with either MV repair (n = 19) or replacement (n = 5). Extensive @entity8 was performed from commissure to commissure in all @entity0 . The annulus was reconstructed with pledgeted compression sutures in 17 @entity0 , and with a @entity2 pericardial patch in seven. RESULTS: In-hospital mortality was 12.5%. One @entity0 died in the operating room from @entity4 , and two @entity0 died from low cardiac output postoperatively. During a mean follow up of 4.4    2.7 years, eight @entity0 died; five of these deaths were cardiovascular in nature. After five years the actuarial survival was 56    11%, and freedom from @entity1 63    11%. Four @entity0 underwent' reoperation because of failure of MV repair (n = 2), @entity6 (n = 1) or @entity7 (n = 1). All survivors were in NYHA class  <= 2, with none to trivial @entity3 in all MV repairs. The five-year freedom from MV reoperation was 82    8%. CONCLUSION: After aggressive @entity8 of the posterior MV annulus, both MV repair and replacement were feasible, with acceptable procedure-related mortality. It was clear however, that @entity8 increased both complexity and risk. In well-selected @entity0 , an aggressive approach to MV repair might facilitate a high rate of repair with acceptable midterm outcome in this @entity0 population.

title: Mitral Valve Repair is Feasible Following Extensive XXXX and Reconstruction of the Atrioventricular Groove.

answer: @entity8


abstract: OBJECTIVE: We sought to compare the skin microbiota above and below the panniculus of third-trimester pregnant @entity0 with @entity1 . METHODS: We collected swabs from the anterior panniculus and from the intertriginous area under the panniculus of @entity0 with @entity1 (body mass index   >= 40 kg/m(2)) carrying a live singleton at   >= 28 weeks. DNA was extracted. PCR with primers targeting the 16S rDNA V4 region were used to prepare an amplicon library. PCR products were sequenced (Illumina MiSeq platform). The 16S rDNA sequences were processed, integrated, analyzed and reported using QIIME and in-house developed scripts. Taxonomy was assigned using RDP Classifier (threshold 0.8) against the Greengenes 16S rDNA database. RESULTS: Twenty @entity0 were enrolled. One sample pair was excluded for low sequence depth. Using permutation testing, there was significantly less bacterial diversity in the samples above compared to below the panniculus (beta diversity using weighted UniFrac metrics; p   <   0.001). CONCLUSION: In pregnant @entity0 with @entity1 , the skin microbiota in the subpannicular fold differs from and is more diverse than that on the anterior panniculus.

title: Gravidas with XXXX : evaluating the abdominal skin microbiota above and below the panniculus.

answer: @entity1


abstract: BACKGROUND: @entity3 has been frequently observed in @entity4 @entity1 in different studies. Finding out the severity of @entity3 --is perhaps equally important, as it has practical as well as prognostic implications. The objective of the study was to assess the severity of @entity3 in @entity0 suffering, from @entity1 caused by @entity4 . METHODS: This cross-sectional study was carried out at Combined Military Hospital (CMH) Malir, Karachi, which is a tertiary care Hospital for all military personnel _ their families in the province of Sindh. All @entity0 of smear positive Vivax malariaduring the study period were, included, and those having @entity3 from any other reason were excluded. They were treated with antimalarial drugs and their platelet counts were monitored till they normalized and discharged from the hospital. Thrombobytopenia was defined as platelets count of <150,000/cu mm. Results were. analysed by SPSS 11. RESULTS: Out of 150 cases, 133 (88%) had @entity3 . Their ages ranged from 15 to 55; mean age was 35 with SD +/- 20. Low platelet count observed was between 11,000 and 146,000/cu mm with SD +/- 27404. Mean value was 79,832/cu mm. None of the @entity0 had any @entity2 episode requiring a blood transfusion. CONCLUSION: @entity4 associated @entity3 has a benign outcome. irrespective of severity of the platelet counts.

title: SEVERITY OF THROMBOCYTOPENIA IN @entity0 WITH XXXX MALARIA; A SINGLE CENTER STUDY.

answer: @entity4


abstract: BACKGROUND: @entity3 has been frequently observed in @entity4 @entity1 in different studies. Finding out the severity of @entity3 --is perhaps equally important, as it has practical as well as prognostic implications. The objective of the study was to assess the severity of @entity3 in @entity0 suffering, from @entity1 caused by @entity4 . METHODS: This cross-sectional study was carried out at Combined Military Hospital (CMH) Malir, Karachi, which is a tertiary care Hospital for all military personnel _ their families in the province of Sindh. All @entity0 of smear positive Vivax malariaduring the study period were, included, and those having @entity3 from any other reason were excluded. They were treated with antimalarial drugs and their platelet counts were monitored till they normalized and discharged from the hospital. Thrombobytopenia was defined as platelets count of <150,000/cu mm. Results were. analysed by SPSS 11. RESULTS: Out of 150 cases, 133 (88%) had @entity3 . Their ages ranged from 15 to 55; mean age was 35 with SD +/- 20. Low platelet count observed was between 11,000 and 146,000/cu mm with SD +/- 27404. Mean value was 79,832/cu mm. None of the @entity0 had any @entity2 episode requiring a blood transfusion. CONCLUSION: @entity4 associated @entity3 has a benign outcome. irrespective of severity of the platelet counts.

title: SEVERITY OF THROMBOCYTOPENIA IN XXXX WITH @entity4 MALARIA; A SINGLE CENTER STUDY.

answer: @entity0


abstract: UNASSIGNED: Aqueous solutions of oxalato- and citrato-VO(2+) complexes are prepared, and their ligand exchange reaction is investigated as a function of the amount of @entity1 present in the aqueous solution via continuous-wave electron paramagnetic resonance (CW EPR) and hyperfine sublevel correlation (HYSCORE) spectroscopy. With a low amount of @entity1 , monomeric cis-oxalato-VO(2+) complexes occur with a distorted square-pyramidal geometry. As the amount of @entity1 increases, oxalate is gradually exchanged for @entity1 . This leads to (i) an intermediate situation of monomeric @entity2 complexes with a mix of oxalate/ @entity1 ligands and (ii) a final situation of both monomeric and dimeric complexes with exclusively citrato ligands. The monomeric citrato-VO(2+) complexes dominate (abundance > 80%) and are characterized by a 6-fold chelation of the vanadium(IV) ion by 4 RCO2(-) ligands at the equatorial positions and a H2O/R-OH ligand at the axial position. The different redox stabilities of these complexes, relative to that of dissolved O2 in the aqueous solution, is analyzed via (51)V NMR. It is shown that the oxidation rate is the highest for the oxalato-VO(2+) complexes. In addition, the stability of the @entity2 complexes can be drastically improved by evacuation of the dissolved O2 from the solution and subsequent storage in a N2 ambient atmosphere. The @entity3 phase formation process, starting with the chemical solution deposition of the aqueous solutions and continuing with subsequent processing in an ambient 0.1% O2 atmosphere, differs for the two complexes. The oxalato-VO(2+) complexes turn into the @entity0 -deficient crystalline VO2 B at 400   C, which then turns into crystalline V6O13 at 500   C. In contrast, the citrato-VO(2+) complexes form an amorphous film at 400   C that crystallizes into VO2 M1 and V6O13 at 500   C.

title: Chemical Composition of an Aqueous Oxalato-/Citrato-VO(2+) Solution as Determinant for XXXX Phase Formation.

answer: @entity3


abstract: A 68-year-old @entity1 presented complaining of 2  months vague abdominal fullness and @entity10 . She had a history of surgery 5  years ago for @entity9 of the left breast. She had good appetite without any severe symptoms such as @entity7 , @entity5 , or @entity6 . No abnormal subcutaneous lymph nodes were detected, and blood tests showed no abnormalities including serum @entity3 markers. Whole-body computed tomography and bone scintigraphy revealed no @entity3 recurrences. However, endoscopic findings demonstrated a smooth @entity4 with submucosal thickening in the transverse colon, but the @entity8 was grossly normal. The 3-cm-long @entity4 was confirmed by colon imaging using water-soluble contrast medium. A biopsy specimen revealed diffuse infiltration of noncohesive malignant cells with round, atypical nuclei from lamina propria to subserosa. Taken together with immunohistochemistry, a diagnosis of metastatic @entity9 from the breast was made, and transverse segmentectomy was done. Colonic @entity2 of @entity0 should be included as a differential diagnosis of any abdominal symptoms, even though mild, when @entity1 have a present or previous history of @entity0 .

title: Scirrhous colonic XXXX from @entity9 of breast.

answer: @entity2


abstract: A 68-year-old @entity1 presented complaining of 2  months vague abdominal fullness and @entity10 . She had a history of surgery 5  years ago for @entity9 of the left breast. She had good appetite without any severe symptoms such as @entity7 , @entity5 , or @entity6 . No abnormal subcutaneous lymph nodes were detected, and blood tests showed no abnormalities including serum @entity3 markers. Whole-body computed tomography and bone scintigraphy revealed no @entity3 recurrences. However, endoscopic findings demonstrated a smooth @entity4 with submucosal thickening in the transverse colon, but the @entity8 was grossly normal. The 3-cm-long @entity4 was confirmed by colon imaging using water-soluble contrast medium. A biopsy specimen revealed diffuse infiltration of noncohesive malignant cells with round, atypical nuclei from lamina propria to subserosa. Taken together with immunohistochemistry, a diagnosis of metastatic @entity9 from the breast was made, and transverse segmentectomy was done. Colonic @entity2 of @entity0 should be included as a differential diagnosis of any abdominal symptoms, even though mild, when @entity1 have a present or previous history of @entity0 .

title: Scirrhous colonic @entity2 from XXXX of breast.

answer: @entity9


abstract: OBJECTIVE: Prior research has documented favorable effects of active and educational videogames among adolescents. However, research on potential negative effects of such games is limited. Scholars have called attention to games portraying sexualized female characters. The purpose of the current study was to experimentally investigate the effect of playing a videogame with a sexualized female character on adolescents' acceptance of rape myths and tolerance for @entity1 . MATERIALS AND METHODS: Fifty-seven secondary school pupils, 12-15 years of age, participated in a 2 (gender: @entity0 versus @entity0 )*2 (game character: nonsexualized versus sexualized female) factorial design experiment. @entity0 played a game for 15 minutes and were randomly assigned to one of the two game characters. Afterward, they completed established scales to assess rape myth acceptance and tolerance for @entity1 . RESULTS: Analyses of variance showed greater acceptance of rape myths (P=0.039) and greater tolerance of @entity1 (P=0.046) in adolescents who played with the sexualized @entity0 compared with adolescents in the control condition. We did not find significant differences between @entity0 and @entity0 or any interaction effect between gender and game character. CONCLUSIONS: Findings suggest that gameplaying with a sexualized @entity0 may increase adolescents' acceptance of rape myths and tolerance for @entity1 . These findings highlight attention to the use of sexualized female game characters in (educational and active) videogames that target adolescents.

title: Playing a Videogame with a Sexualized Female Character Increases Adolescents' Rape Myth Acceptance and Tolerance Toward XXXX .

answer: @entity1


abstract: BACKGROUND: @entity3 (NO) has been largely associated with cardiovascular protection through improvement of endothelial function. Recently, new evidence about modulation of NO release by microRNAs (miRs) has been reported, which could be involved with statin-dependent pleiotropic effects, including anti-inflammatory properties related to vascular endothelium function. OBJECTIVE: To evaluate the effects of @entity1 -lowering drugs including the inhibitors of @entity1 synthesis, @entity5 and @entity6 , and the inhibitor of @entity1 absorption @entity7 on NO release, @entity9 mRNA expression and miRs potentially involved in NO bioavailability. METHODS: @entity0 umbilical vein endothelial cells (HUVEC) were exposed to @entity5 , @entity6 or @entity7 (0 to 5.0  M). Cells were submitted to total RNA extraction and relative quantification of @entity9 mRNA and miRs -221, -222 and -1303 by qPCR. NO release was measured in supernatants by @entity4 -chemiluminescence. RESULTS: Both @entity8 increased NO levels and @entity9 mRNA expression but no influence was observed for @entity7 treatment. @entity5 , @entity6 and @entity7 down-regulated the expression of @entity2 , whereas @entity10 was reduced only after the @entity5 treatment. The magnitude of the reduction of @entity2 and @entity10 after treatment with @entity8 correlated with the increment in @entity9 mRNA levels. No influence was observed on the miR-1303 expression after treatments. CONCLUSION: NO release in endothelial cells is increased by @entity8 but not by the inhibitor of @entity1 absorption, @entity7 . Our results provide new evidence about the participation of regulatory miRs 221/222 on NO release induction mediated by @entity8 . Although @entity7 did not modulate NO levels, the down-regulation of @entity2 could involve potential effects on endothelial function.

title: Role of microRNAs 221/222 on @entity8 Induced XXXX Release in @entity0 Endothelial Cells.

answer: @entity3


abstract: BACKGROUND: @entity3 (NO) has been largely associated with cardiovascular protection through improvement of endothelial function. Recently, new evidence about modulation of NO release by microRNAs (miRs) has been reported, which could be involved with statin-dependent pleiotropic effects, including anti-inflammatory properties related to vascular endothelium function. OBJECTIVE: To evaluate the effects of @entity1 -lowering drugs including the inhibitors of @entity1 synthesis, @entity5 and @entity6 , and the inhibitor of @entity1 absorption @entity7 on NO release, @entity9 mRNA expression and miRs potentially involved in NO bioavailability. METHODS: @entity0 umbilical vein endothelial cells (HUVEC) were exposed to @entity5 , @entity6 or @entity7 (0 to 5.0  M). Cells were submitted to total RNA extraction and relative quantification of @entity9 mRNA and miRs -221, -222 and -1303 by qPCR. NO release was measured in supernatants by @entity4 -chemiluminescence. RESULTS: Both @entity8 increased NO levels and @entity9 mRNA expression but no influence was observed for @entity7 treatment. @entity5 , @entity6 and @entity7 down-regulated the expression of @entity2 , whereas @entity10 was reduced only after the @entity5 treatment. The magnitude of the reduction of @entity2 and @entity10 after treatment with @entity8 correlated with the increment in @entity9 mRNA levels. No influence was observed on the miR-1303 expression after treatments. CONCLUSION: NO release in endothelial cells is increased by @entity8 but not by the inhibitor of @entity1 absorption, @entity7 . Our results provide new evidence about the participation of regulatory miRs 221/222 on NO release induction mediated by @entity8 . Although @entity7 did not modulate NO levels, the down-regulation of @entity2 could involve potential effects on endothelial function.

title: Role of microRNAs 221/222 on XXXX Induced @entity3 Release in @entity0 Endothelial Cells.

answer: @entity8


abstract: BACKGROUND: @entity3 (NO) has been largely associated with cardiovascular protection through improvement of endothelial function. Recently, new evidence about modulation of NO release by microRNAs (miRs) has been reported, which could be involved with statin-dependent pleiotropic effects, including anti-inflammatory properties related to vascular endothelium function. OBJECTIVE: To evaluate the effects of @entity1 -lowering drugs including the inhibitors of @entity1 synthesis, @entity5 and @entity6 , and the inhibitor of @entity1 absorption @entity7 on NO release, @entity9 mRNA expression and miRs potentially involved in NO bioavailability. METHODS: @entity0 umbilical vein endothelial cells (HUVEC) were exposed to @entity5 , @entity6 or @entity7 (0 to 5.0  M). Cells were submitted to total RNA extraction and relative quantification of @entity9 mRNA and miRs -221, -222 and -1303 by qPCR. NO release was measured in supernatants by @entity4 -chemiluminescence. RESULTS: Both @entity8 increased NO levels and @entity9 mRNA expression but no influence was observed for @entity7 treatment. @entity5 , @entity6 and @entity7 down-regulated the expression of @entity2 , whereas @entity10 was reduced only after the @entity5 treatment. The magnitude of the reduction of @entity2 and @entity10 after treatment with @entity8 correlated with the increment in @entity9 mRNA levels. No influence was observed on the miR-1303 expression after treatments. CONCLUSION: NO release in endothelial cells is increased by @entity8 but not by the inhibitor of @entity1 absorption, @entity7 . Our results provide new evidence about the participation of regulatory miRs 221/222 on NO release induction mediated by @entity8 . Although @entity7 did not modulate NO levels, the down-regulation of @entity2 could involve potential effects on endothelial function.

title: Role of microRNAs 221/222 on @entity8 Induced @entity3 Release in XXXX Endothelial Cells.

answer: @entity0


abstract: PURPOSE: To compare the rates of success of two-dimensional (2D) and three-dimensional (3D) sonographic (US) examinations in locating and adequately visualizing @entity1 intrauterine devices (IUDs) and to explore factors associated with the unsuccessful viewing on 2D US. METHODS: Transvaginal 2D and 3D US examinations were performed on all @entity0 1 month after insertion of @entity1 IUDs. The devices were considered adequately visualized on 2D US if both the vertical (shadow, upper and lower extremities) and the horizontal (two echogenic lines) shafts were identified. 3D volumes were also captured to assess the location of @entity1 IUDs on 3D US. RESULTS: Thirty @entity0 were included. The rates of adequate device visualization were 40% on 2D US (95% confidence interval [CI], 24.6; 57.7) and 100% on 3D US (95% CI, 88.6; 100.0). The device was not adequately visualized in all six @entity0 who had a retroflexed uterus, but it was adequately visualized in 12 of the 24 @entity0 (50%) who had a nonretroflexed uterus (95% CI, -68.6; -6.8). CONCLUSIONS: We found that 3D US is better than 2D US for locating and adequately visualizing @entity1 IUDs. Other well-designed studies with adequate power should be conducted to confirm this finding.    2015 Wiley Periodicals, Inc. J Clin Ultrasound, 2015.

title: Three-dimensional versus two-dimensional ultrasound for assessing XXXX intrauterine device location: A pilot study.

answer: @entity1


abstract: BACKGROUND: By the early nineteenth century, @entity0 was better understood and surgical treatment was emerging as a more favoured option although anaesthesia had yet to be discovered. Many questions would have arisen for a @entity1 advised to have surgery, including possible alternatives, what the operation would entail, @entity2 and risks involved and the competence, ethical and professional behaviour of the surgeon. This paper addresses these questions in the context of the contemporary environment, focusing in particular on the personal experiences of the @entity1 involved. METHODS: A review of the surviving personal letters and information regarding three @entity1 who had breast surgery, and of the contemporary surgical writings on @entity0 , training of surgeons, ethical and professional expectations and the concurrent status of @entity1 in society. RESULTS: Surgical training was in its infancy and the first pronouncements on medical ethics had just been published. @entity2 , @entity4 and @entity3 presented formidable challenges and carried significant risks. @entity1 were frequently devoid of information, suffered a loss of their dignity and were progressively stripped of their authority. CONCLUSIONS: @entity0 surgery was accompanied by enormous emotional and physical distress and significant risks from @entity4 and @entity3 . Although efforts were being made to give @entity1 a greater voice and autonomy in society, their position when receiving health care remained largely a submissive one. Lack of information, feelings of vulnerability, helplessness and loss of control occurred. The public perception of detachment most likely accounted for the occasional negative stigma then associated with the surgical profession.

title: Mastectomy with tears: XXXX surgery in the early nineteenth century.

answer: @entity0


abstract: OBJECTIVE: To describe the etiologies, clinical presentations, outcomes, and predictors of @entity3 ( @entity3 ) in a large series of adult @entity0 with acute @entity2 . METHODS: We conducted a retrospective review of @entity0 diagnosed with acute @entity2 at Mayo Clinic, Rochester, between January 2000 and December 2012. The @entity0 were categorized into two groups based on the presence or absence of @entity3 at last follow-up. Multivariate logistic regression analysis was used to analyze factors associated with @entity3 . RESULTS: We identified 198 consecutive @entity0 (100 [50.5%] male and 98 [49.5%] female) with a median age of 58  years (range 41.8-69). Etiologies included @entity5 (n  =  95, 48%), autoimmune (n  =  44, 22%), and unknown/others (n  =  59, 30%). During hospitalization, @entity4 were seen in @entity0 with @entity7 (n  =  24, 54.5%), unknown/others (n  =  20, 33.9%), and @entity6 (n  =  23, 24.2%). Interictal epileptiform discharges on electroencephalography (EEG) were present in 34 (54%), whereas periodic lateralized epileptiform discharges (PLEDs) and generalized periodic discharges (GPDs) were seen in 14 (41.2%) and 2 (5.9%) @entity0 . Forty-six @entity0 with @entity4 (70.8%) had fluid-attenuated inversion recovery (FLAIR)/T2 abnormalities, 20 (31.3%) diffusion abnormalities, and 43 (66.2%) cortical involvement. Good outcome at discharge among @entity0 with @entity4 was seen in 8/23 @entity0 with viral etiology (34.8%), 10/24 @entity0 with @entity7 (45.5%), and 12/20 @entity0 with unknown cause (60%). @entity3 was present in 43 @entity0 (29.9%). On multivariate regression analysis, the factors associated with @entity3 were generalized @entity4 during hospitalization (p  =  0.03), focal @entity4 (p   <=  0.001), and the presence of FLAIR/T2 abnormalities on brain magnetic resonance imaging (MRI) (p  =  0.003). SIGNIFICANCE: The presence of @entity4 during hospitalization and an abnormal brain MRI are the strongest predictors of the development of @entity3 . The etiology of @entity2 , presence of focal @entity1 , and interictal EEG abnormalities did not influence the development of @entity3 .

title: XXXX : Clinical characteristics and predictors.

answer: @entity3


abstract: OBJECTIVE: To perform a meta-analysis of studies investigating the effects of low-frequency repetitive transcranial magnetic stimulation on post- @entity2 @entity3 . DATA SOURCES: Studies were identified by performing a search of electronic databases (MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Knowledge) for articles published until June 2014. STUDY SELECTION: @entity1 ( @entity1 ) reporting treatments with low-frequency repetitive transcranial magnetic stimulation in @entity0 with post- @entity2 @entity3 were included. The outcomes included naming, repetition, comprehension, changes in brain excitability, and adverse events. DATA EXTRACTION: Two independent reviewers extracted the data. Study quality was evaluated with the PEDro scale. DATA ANALYSIS: Of the 879 articles identified, 4 @entity1 were included in the final analysis. Data synthesis showed that low-frequency repetitive transcranial magnetic stimulation was beneficial for post- @entity2 @entity0 in terms of naming (standard mean difference (SMD) 0.51; 95% confidence interval (95% CI) 0.16-0.86) and changes in brain excitability (7.6        33.55; 95% CI -10.7-26.20). However, the changes in repetition (SMD 0.31; 95% CI -0.04-0.65) and comprehension (SMD 0.31; 95% CI -0.14-0.75) after stimulation were not significant. No adverse effects were reported. The included studies were of high methodological quality. CONCLUSION: These findings indicate that low-frequency repetitive transcranial magnetic stimulation is an effective treatment for recovery of naming. In addition, this treatment favours reorganization of the left-hemispheric language networks.

title: Low-frequency repetitive transcranial magnetic stimulation for @entity0 with XXXX after stoke: A meta-analysis.

answer: @entity3


abstract: OBJECTIVE: To perform a meta-analysis of studies investigating the effects of low-frequency repetitive transcranial magnetic stimulation on post- @entity2 @entity3 . DATA SOURCES: Studies were identified by performing a search of electronic databases (MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Knowledge) for articles published until June 2014. STUDY SELECTION: @entity1 ( @entity1 ) reporting treatments with low-frequency repetitive transcranial magnetic stimulation in @entity0 with post- @entity2 @entity3 were included. The outcomes included naming, repetition, comprehension, changes in brain excitability, and adverse events. DATA EXTRACTION: Two independent reviewers extracted the data. Study quality was evaluated with the PEDro scale. DATA ANALYSIS: Of the 879 articles identified, 4 @entity1 were included in the final analysis. Data synthesis showed that low-frequency repetitive transcranial magnetic stimulation was beneficial for post- @entity2 @entity0 in terms of naming (standard mean difference (SMD) 0.51; 95% confidence interval (95% CI) 0.16-0.86) and changes in brain excitability (7.6        33.55; 95% CI -10.7-26.20). However, the changes in repetition (SMD 0.31; 95% CI -0.04-0.65) and comprehension (SMD 0.31; 95% CI -0.14-0.75) after stimulation were not significant. No adverse effects were reported. The included studies were of high methodological quality. CONCLUSION: These findings indicate that low-frequency repetitive transcranial magnetic stimulation is an effective treatment for recovery of naming. In addition, this treatment favours reorganization of the left-hemispheric language networks.

title: Low-frequency repetitive transcranial magnetic stimulation for XXXX with @entity3 after stoke: A meta-analysis.

answer: @entity0


abstract: PURPOSE: To evaluate the refractive and keratometric effect of arcuate keratotomy using femtosecond technology in @entity0 with high post-keratoplasty @entity1 with a mushroom profile. SETTING: Enaim Refractive Center, @entity2 -Aviv, Israel. DESIGN: Noncomparative prospective interventional case series. METHODS: The arcuate depth incision was set to 80% of the minimal graft thickness, with a 60-degree angle. The mean diameter was 5.79 mm    0.32 (SD) according to the graft size. @entity0 evaluation included logMAR corrected distance visual acuity (CDVA), refraction, keratometry (K), and a complete eye examination. RESULTS: Twenty-seven eyes of 27 @entity0 after keratoplasty surgery were included. Both uncorrected distance visual acuity and logMAR CDVA improved after surgery. The preoperative mean logMAR CDVA was 0.29    0.37 (SD), which improved by 1 line (to 0.19    0.10; P = .01). The mean refractive @entity1 was -8.43    2.80 diopters (D) (range -4.5 to -15 D), and it declined at the 3-month postsurgical follow-up to -4.31    0.23 D (P < .001) and remained stable until the end of follow-up (-3.31    1.39 D; P = 1.00). The K value decreased by 1.18 D (P  < .001). There were no complications or adverse effects during the follow-up period. CONCLUSIONS: Arcuate keratotomies performed with the femtosecond laser showed good results. There was a more than 50% decrease in post-mushroom profile keratoplasty @entity1 as well as stability of the results over 1 year. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Correction ratio and vector analysis of  femtosecond laser arcuate keratotomy for  the correction of post-mushroom profile  keratoplasty XXXX .

answer: @entity1


abstract: UNASSIGNED: Although @entity1 is an accepted method for the treatment of @entity4 , this therapy has high recurrence and complication rates, and prolonged follow-up studies on the parameters associated with various outcomes are rare. In this prospective 10-year follow-up study, a satisfactory therapeutic effect was achieved without serious complications. We report the therapeutic experience with @entity1 , having aimed to evaluate the long-term clinical safety and efficacy of @entity1 .In total, 35 consecutive @entity0 with idiopathic @entity4 who underwent @entity1 were followed up at regular intervals in @entity0 or by a phone interview over a 10-year period. The mean duration of the follow-up was 43.03  26.34 months (range 6-120 months). Remission was assessed by the @entity3 classification and symptom scores. @entity0 ' clinical symptom scores were calculated before and at 6 to 36months, 37 to 60months, and >60months after therapy. The influence of the @entity0 ' age, gender, and disease duration on the therapeutic effect was analyzed.The success rate of the operation was 97.2% (35/36), without massive @entity2 , perforation or other serious complications. @entity3 after the therapy was significantly eased (P<0.01). In total, 35 @entity0 have been followed up for 6 to 36months after therapy, 21 cases for 37 to 60months, and 5 cases for >60months, and the @entity0 ' symptom scores separately decreased significantly compared with the pretherapy scores (P<0.01). For these @entity0 , the 6 to 36months remission rate was 85.7% (30/35), the 37 to 60months rate was 61.9% (13/21), and the >60months rate was 40% (2/5). The dilation effect had no relationship to the @entity0 's age, gender, and disease duration (P>0.05). The @entity0 in 30 cases (85.7%) were successfully treated with a single dilation, in 4 cases (11.4%) with 2 dilations, and in 1 case (2.9%) with 3 dilations.These results suggest that endoscopic @entity1 is an @entity4 therapy with a good response; it is a simple and safe procedure with long-term clinical effectiveness. It is a preferred method in the treatment of @entity4 .

title: Clinical Effect of Endoscopic Pneumatic Dilation for XXXX .

answer: @entity4


abstract: AIM: To investigate the nature of @entity7 and its diversity in @entity0 with @entity4 . METHODS: The reports of the kidney biopsies performed due to @entity6 (>3.5   g/day/1.73   m(2)) with preserved renal function [glomerular filtration rate (GFR) >60   mL/ @entity3 .73   m(2)] were reviewed. Clinical and laboratory data of the @entity0 with @entity4 and @entity1 ( @entity1 ) were analyzed. RESULTS: A total of 104 ( @entity4 : 43, @entity1 : 61) @entity0 were included in the study. @entity2 and GFR levels were similar in both the groups. @entity0 with @entity4 group had lower serum albumin (p   =   0.002), lower hemoglobin levels (p   =   0.001), higher platelet counts (p   =   0.002) and higher @entity5 levels (p   =   0.001) compared to @entity0 in @entity1 group. Although the frequency of @entity7 was similar in the groups (86.0 vs. 93.4%), @entity0 with @entity4 had both lower values of LDL-C (4.56        2.05 vs. 5.49        2.23   mmol/L, p   =   0.028) and HDL-C (1.19        0.36 vs. 1.35        0.39   mmol/L, p   =   0.035). Serum lipid levels were correlated with serum total protein, albumin and @entity2 levels in @entity1 group. However, in the @entity4 group, only one clear correlation between serum lipid and hemoglobin levels was estimated. A multivariate analysis demonstrated that LDL-C was independently associated with the etiology of @entity6 , serum total protein, serum albumin (inversely) and hemoglobin levels. CONCLUSIONS: Although @entity7 is closely associated with serum total protein, albumin and @entity2 in @entity0 with @entity1 , there is no clear such association in @entity0 with @entity4 . Correlation between serum lipid and hemoglobin levels in this group and other findings point out that probably complex mechanisms take place in @entity7 of @entity6 caused by @entity4 .

title: Unknown aspect of the old disease: does @entity7 in @entity4 in XXXX ?

answer: @entity1


abstract: AIM: To investigate the nature of @entity7 and its diversity in @entity0 with @entity4 . METHODS: The reports of the kidney biopsies performed due to @entity6 (>3.5   g/day/1.73   m(2)) with preserved renal function [glomerular filtration rate (GFR) >60   mL/ @entity3 .73   m(2)] were reviewed. Clinical and laboratory data of the @entity0 with @entity4 and @entity1 ( @entity1 ) were analyzed. RESULTS: A total of 104 ( @entity4 : 43, @entity1 : 61) @entity0 were included in the study. @entity2 and GFR levels were similar in both the groups. @entity0 with @entity4 group had lower serum albumin (p   =   0.002), lower hemoglobin levels (p   =   0.001), higher platelet counts (p   =   0.002) and higher @entity5 levels (p   =   0.001) compared to @entity0 in @entity1 group. Although the frequency of @entity7 was similar in the groups (86.0 vs. 93.4%), @entity0 with @entity4 had both lower values of LDL-C (4.56        2.05 vs. 5.49        2.23   mmol/L, p   =   0.028) and HDL-C (1.19        0.36 vs. 1.35        0.39   mmol/L, p   =   0.035). Serum lipid levels were correlated with serum total protein, albumin and @entity2 levels in @entity1 group. However, in the @entity4 group, only one clear correlation between serum lipid and hemoglobin levels was estimated. A multivariate analysis demonstrated that LDL-C was independently associated with the etiology of @entity6 , serum total protein, serum albumin (inversely) and hemoglobin levels. CONCLUSIONS: Although @entity7 is closely associated with serum total protein, albumin and @entity2 in @entity0 with @entity1 , there is no clear such association in @entity0 with @entity4 . Correlation between serum lipid and hemoglobin levels in this group and other findings point out that probably complex mechanisms take place in @entity7 of @entity6 caused by @entity4 .

title: Unknown aspect of the old disease: does XXXX in @entity4 in @entity1 ?

answer: @entity7


abstract: AIM: To investigate the nature of @entity7 and its diversity in @entity0 with @entity4 . METHODS: The reports of the kidney biopsies performed due to @entity6 (>3.5   g/day/1.73   m(2)) with preserved renal function [glomerular filtration rate (GFR) >60   mL/ @entity3 .73   m(2)] were reviewed. Clinical and laboratory data of the @entity0 with @entity4 and @entity1 ( @entity1 ) were analyzed. RESULTS: A total of 104 ( @entity4 : 43, @entity1 : 61) @entity0 were included in the study. @entity2 and GFR levels were similar in both the groups. @entity0 with @entity4 group had lower serum albumin (p   =   0.002), lower hemoglobin levels (p   =   0.001), higher platelet counts (p   =   0.002) and higher @entity5 levels (p   =   0.001) compared to @entity0 in @entity1 group. Although the frequency of @entity7 was similar in the groups (86.0 vs. 93.4%), @entity0 with @entity4 had both lower values of LDL-C (4.56        2.05 vs. 5.49        2.23   mmol/L, p   =   0.028) and HDL-C (1.19        0.36 vs. 1.35        0.39   mmol/L, p   =   0.035). Serum lipid levels were correlated with serum total protein, albumin and @entity2 levels in @entity1 group. However, in the @entity4 group, only one clear correlation between serum lipid and hemoglobin levels was estimated. A multivariate analysis demonstrated that LDL-C was independently associated with the etiology of @entity6 , serum total protein, serum albumin (inversely) and hemoglobin levels. CONCLUSIONS: Although @entity7 is closely associated with serum total protein, albumin and @entity2 in @entity0 with @entity1 , there is no clear such association in @entity0 with @entity4 . Correlation between serum lipid and hemoglobin levels in this group and other findings point out that probably complex mechanisms take place in @entity7 of @entity6 caused by @entity4 .

title: Unknown aspect of the old disease: does @entity7 in XXXX in @entity1 ?

answer: @entity4


abstract: UNASSIGNED: Although dietary @entity14 restriction is important for treating @entity11 in @entity0 with @entity9 , it remains unclear whether a @entity6 ( @entity6 ), which includes low @entity14 , has beneficial effects on @entity13 , @entity2 , and @entity8 . The effects of @entity6 on @entity2 , @entity13 , and @entity8 were therefore assessed in @entity3 . @entity3 were fed a normal diet or diets containing 0.3% @entity15 and low/normal protein and low/high @entity14 . After 6 weeks, serum and urinary biochemical parameters, systemic @entity2 , and @entity8 were examined. The protective effect of @entity16 and albumin were assessed in cultured vascular smooth muscle cells. @entity3 fed the diet containing 0.3% @entity15 developed severe @entity12 . @entity6 in @entity3 fed high @entity14 induced @entity13 (decreases in body weight, food intake, serum albumin and @entity16 levels, and urinary @entity10 excretion) and systemic @entity2 (increases in serum @entity1 @entity4 factor-a and urinary oxidative stress marker). @entity6 decreased serum @entity16 level and @entity16 synthesis in the liver and increased serum @entity5 precipitates. High @entity14 diet increased aortic @entity7 content, which was enhanced by @entity6 . Reduced fetal calf serum in the medium of cultured vascular smooth muscle cells enhanced @entity14 -induced formation of @entity5 precipitates in the media and calcification of vascular smooth muscle cells, both of which were prevented by @entity16 administration. Our results suggest that @entity14 restriction by restricting dietary protein promotes @entity8 by lowering systemic @entity16 level and increasing serum @entity5 precipitates and induces @entity2 and @entity13 in uremic @entity3 fed a high @entity14 diet.

title: @entity16 decrease induced by a @entity6 enhances XXXX in uremic @entity3 with @entity11 .

answer: @entity8


abstract: UNASSIGNED: Although dietary @entity14 restriction is important for treating @entity11 in @entity0 with @entity9 , it remains unclear whether a @entity6 ( @entity6 ), which includes low @entity14 , has beneficial effects on @entity13 , @entity2 , and @entity8 . The effects of @entity6 on @entity2 , @entity13 , and @entity8 were therefore assessed in @entity3 . @entity3 were fed a normal diet or diets containing 0.3% @entity15 and low/normal protein and low/high @entity14 . After 6 weeks, serum and urinary biochemical parameters, systemic @entity2 , and @entity8 were examined. The protective effect of @entity16 and albumin were assessed in cultured vascular smooth muscle cells. @entity3 fed the diet containing 0.3% @entity15 developed severe @entity12 . @entity6 in @entity3 fed high @entity14 induced @entity13 (decreases in body weight, food intake, serum albumin and @entity16 levels, and urinary @entity10 excretion) and systemic @entity2 (increases in serum @entity1 @entity4 factor-a and urinary oxidative stress marker). @entity6 decreased serum @entity16 level and @entity16 synthesis in the liver and increased serum @entity5 precipitates. High @entity14 diet increased aortic @entity7 content, which was enhanced by @entity6 . Reduced fetal calf serum in the medium of cultured vascular smooth muscle cells enhanced @entity14 -induced formation of @entity5 precipitates in the media and calcification of vascular smooth muscle cells, both of which were prevented by @entity16 administration. Our results suggest that @entity14 restriction by restricting dietary protein promotes @entity8 by lowering systemic @entity16 level and increasing serum @entity5 precipitates and induces @entity2 and @entity13 in uremic @entity3 fed a high @entity14 diet.

title: @entity16 decrease induced by a @entity6 enhances @entity8 in uremic XXXX with @entity11 .

answer: @entity3


abstract: UNASSIGNED: Although dietary @entity14 restriction is important for treating @entity11 in @entity0 with @entity9 , it remains unclear whether a @entity6 ( @entity6 ), which includes low @entity14 , has beneficial effects on @entity13 , @entity2 , and @entity8 . The effects of @entity6 on @entity2 , @entity13 , and @entity8 were therefore assessed in @entity3 . @entity3 were fed a normal diet or diets containing 0.3% @entity15 and low/normal protein and low/high @entity14 . After 6 weeks, serum and urinary biochemical parameters, systemic @entity2 , and @entity8 were examined. The protective effect of @entity16 and albumin were assessed in cultured vascular smooth muscle cells. @entity3 fed the diet containing 0.3% @entity15 developed severe @entity12 . @entity6 in @entity3 fed high @entity14 induced @entity13 (decreases in body weight, food intake, serum albumin and @entity16 levels, and urinary @entity10 excretion) and systemic @entity2 (increases in serum @entity1 @entity4 factor-a and urinary oxidative stress marker). @entity6 decreased serum @entity16 level and @entity16 synthesis in the liver and increased serum @entity5 precipitates. High @entity14 diet increased aortic @entity7 content, which was enhanced by @entity6 . Reduced fetal calf serum in the medium of cultured vascular smooth muscle cells enhanced @entity14 -induced formation of @entity5 precipitates in the media and calcification of vascular smooth muscle cells, both of which were prevented by @entity16 administration. Our results suggest that @entity14 restriction by restricting dietary protein promotes @entity8 by lowering systemic @entity16 level and increasing serum @entity5 precipitates and induces @entity2 and @entity13 in uremic @entity3 fed a high @entity14 diet.

title: @entity16 decrease induced by a @entity6 enhances @entity8 in uremic @entity3 with XXXX .

answer: @entity11


abstract: UNASSIGNED: Although dietary @entity14 restriction is important for treating @entity11 in @entity0 with @entity9 , it remains unclear whether a @entity6 ( @entity6 ), which includes low @entity14 , has beneficial effects on @entity13 , @entity2 , and @entity8 . The effects of @entity6 on @entity2 , @entity13 , and @entity8 were therefore assessed in @entity3 . @entity3 were fed a normal diet or diets containing 0.3% @entity15 and low/normal protein and low/high @entity14 . After 6 weeks, serum and urinary biochemical parameters, systemic @entity2 , and @entity8 were examined. The protective effect of @entity16 and albumin were assessed in cultured vascular smooth muscle cells. @entity3 fed the diet containing 0.3% @entity15 developed severe @entity12 . @entity6 in @entity3 fed high @entity14 induced @entity13 (decreases in body weight, food intake, serum albumin and @entity16 levels, and urinary @entity10 excretion) and systemic @entity2 (increases in serum @entity1 @entity4 factor-a and urinary oxidative stress marker). @entity6 decreased serum @entity16 level and @entity16 synthesis in the liver and increased serum @entity5 precipitates. High @entity14 diet increased aortic @entity7 content, which was enhanced by @entity6 . Reduced fetal calf serum in the medium of cultured vascular smooth muscle cells enhanced @entity14 -induced formation of @entity5 precipitates in the media and calcification of vascular smooth muscle cells, both of which were prevented by @entity16 administration. Our results suggest that @entity14 restriction by restricting dietary protein promotes @entity8 by lowering systemic @entity16 level and increasing serum @entity5 precipitates and induces @entity2 and @entity13 in uremic @entity3 fed a high @entity14 diet.

title: @entity16 decrease induced by a XXXX enhances @entity8 in uremic @entity3 with @entity11 .

answer: @entity6


abstract: UNASSIGNED: Although dietary @entity14 restriction is important for treating @entity11 in @entity0 with @entity9 , it remains unclear whether a @entity6 ( @entity6 ), which includes low @entity14 , has beneficial effects on @entity13 , @entity2 , and @entity8 . The effects of @entity6 on @entity2 , @entity13 , and @entity8 were therefore assessed in @entity3 . @entity3 were fed a normal diet or diets containing 0.3% @entity15 and low/normal protein and low/high @entity14 . After 6 weeks, serum and urinary biochemical parameters, systemic @entity2 , and @entity8 were examined. The protective effect of @entity16 and albumin were assessed in cultured vascular smooth muscle cells. @entity3 fed the diet containing 0.3% @entity15 developed severe @entity12 . @entity6 in @entity3 fed high @entity14 induced @entity13 (decreases in body weight, food intake, serum albumin and @entity16 levels, and urinary @entity10 excretion) and systemic @entity2 (increases in serum @entity1 @entity4 factor-a and urinary oxidative stress marker). @entity6 decreased serum @entity16 level and @entity16 synthesis in the liver and increased serum @entity5 precipitates. High @entity14 diet increased aortic @entity7 content, which was enhanced by @entity6 . Reduced fetal calf serum in the medium of cultured vascular smooth muscle cells enhanced @entity14 -induced formation of @entity5 precipitates in the media and calcification of vascular smooth muscle cells, both of which were prevented by @entity16 administration. Our results suggest that @entity14 restriction by restricting dietary protein promotes @entity8 by lowering systemic @entity16 level and increasing serum @entity5 precipitates and induces @entity2 and @entity13 in uremic @entity3 fed a high @entity14 diet.

title: XXXX decrease induced by a @entity6 enhances @entity8 in uremic @entity3 with @entity11 .

answer: @entity16


abstract: The objective of present study was to formulate directly compressible orodispersible tablets of @entity1 by sublimation method with a view to enhance @entity0 compliance. A full 3(2) factorial design was used to investigate the effect of two variables viz., concentration of Indion 414 and @entity3 . Indion 414 (3-5 % w/w) was used as superdisintegrant and @entity3 (5-15 % w/w) as subliming agent. The tablets were evaluated for thickness, weight variation, @entity2 , friability, content uniformity, wetting time, porosity, in vitro disintegration time and in vitro drug release. The formulation containing 5% w/w of Indion 414 and 5% w/w @entity3 was emerged as promising based on evaluation parameters. The disintegration time for optimized formulation was 18.66 s. The tablet surface was evaluated for presence of pores by scanning electron microscopy before and after sublimation. Differential scanning colorimetric study did not indicate any drug excipient incompatibility, either during mixing or after compression. The effect of independent variables on disintegration time, % drug release and friability is presented graphically by surface response plots. Short-term stability studies on the optimized formulation indicated no significant changes in drug content and in vitro disintegration time. The directly compressible orodispersible tablets of @entity1 fumarate with lower friability, greater drug release and shorter disintegration times were obtained using Indion 414 and @entity3 at optimum concentrations.

title: Formulation Design and Optimization of Orodispersible Tablets of XXXX by Sublimation Method.

answer: @entity1


abstract: In both the @entity0 and animal literature, it has largely been assumed that @entity1 is the primary cause of @entity5 ( @entity5 ) elevation after @entity3 and that more @entity1 equates to higher @entity5 . We recently demonstrated a dramatic @entity5 elevation 24 hours after small @entity4 in @entity2 , with minimal @entity1 . This @entity5 elevation was completely prevented by short-duration moderate @entity7 soon after @entity3 . Here, our aims were to determine the importance of @entity1 in @entity5 elevation after @entity3 and whether mild @entity7 could prevent the @entity5 rise. @entity3 was performed in @entity2 . @entity5 was monitored and short-duration mild (35   C) or moderate (32.5   C) @entity7 , or normothermia (37   C) was induced after @entity3 onset. @entity1 was measured in three studies, using wet-dry weight calculations, T2-weighted magnetic resonance imaging, or histology. @entity5 increased 24 hours after @entity3 onset in all normothermic animals. Short-duration mild or moderate @entity7 prevented this rise. No correlation was seen between   @entity5 and @entity1 or @entity6 volumes. Calculated rates of @entity1 growth were orders of magnitude less than normal cerebrospinal fluid production rates. These data challenge current concepts and suggest that factors other than @entity8 are the primary cause of the @entity5 elevation 24 hours after @entity3 onset.

title: Intracranial pressure elevation after @entity4 in @entity2 : XXXX is not the only cause, and short-duration mild @entity7 is a highly effective preventive therapy.

answer: @entity8


abstract: In both the @entity0 and animal literature, it has largely been assumed that @entity1 is the primary cause of @entity5 ( @entity5 ) elevation after @entity3 and that more @entity1 equates to higher @entity5 . We recently demonstrated a dramatic @entity5 elevation 24 hours after small @entity4 in @entity2 , with minimal @entity1 . This @entity5 elevation was completely prevented by short-duration moderate @entity7 soon after @entity3 . Here, our aims were to determine the importance of @entity1 in @entity5 elevation after @entity3 and whether mild @entity7 could prevent the @entity5 rise. @entity3 was performed in @entity2 . @entity5 was monitored and short-duration mild (35   C) or moderate (32.5   C) @entity7 , or normothermia (37   C) was induced after @entity3 onset. @entity1 was measured in three studies, using wet-dry weight calculations, T2-weighted magnetic resonance imaging, or histology. @entity5 increased 24 hours after @entity3 onset in all normothermic animals. Short-duration mild or moderate @entity7 prevented this rise. No correlation was seen between   @entity5 and @entity1 or @entity6 volumes. Calculated rates of @entity1 growth were orders of magnitude less than normal cerebrospinal fluid production rates. These data challenge current concepts and suggest that factors other than @entity8 are the primary cause of the @entity5 elevation 24 hours after @entity3 onset.

title: Intracranial pressure elevation after @entity4 in @entity2 : @entity8 is not the only cause, and short-duration mild XXXX is a highly effective preventive therapy.

answer: @entity7


abstract: In both the @entity0 and animal literature, it has largely been assumed that @entity1 is the primary cause of @entity5 ( @entity5 ) elevation after @entity3 and that more @entity1 equates to higher @entity5 . We recently demonstrated a dramatic @entity5 elevation 24 hours after small @entity4 in @entity2 , with minimal @entity1 . This @entity5 elevation was completely prevented by short-duration moderate @entity7 soon after @entity3 . Here, our aims were to determine the importance of @entity1 in @entity5 elevation after @entity3 and whether mild @entity7 could prevent the @entity5 rise. @entity3 was performed in @entity2 . @entity5 was monitored and short-duration mild (35   C) or moderate (32.5   C) @entity7 , or normothermia (37   C) was induced after @entity3 onset. @entity1 was measured in three studies, using wet-dry weight calculations, T2-weighted magnetic resonance imaging, or histology. @entity5 increased 24 hours after @entity3 onset in all normothermic animals. Short-duration mild or moderate @entity7 prevented this rise. No correlation was seen between   @entity5 and @entity1 or @entity6 volumes. Calculated rates of @entity1 growth were orders of magnitude less than normal cerebrospinal fluid production rates. These data challenge current concepts and suggest that factors other than @entity8 are the primary cause of the @entity5 elevation 24 hours after @entity3 onset.

title: Intracranial pressure elevation after XXXX in @entity2 : @entity8 is not the only cause, and short-duration mild @entity7 is a highly effective preventive therapy.

answer: @entity4


abstract: In both the @entity0 and animal literature, it has largely been assumed that @entity1 is the primary cause of @entity5 ( @entity5 ) elevation after @entity3 and that more @entity1 equates to higher @entity5 . We recently demonstrated a dramatic @entity5 elevation 24 hours after small @entity4 in @entity2 , with minimal @entity1 . This @entity5 elevation was completely prevented by short-duration moderate @entity7 soon after @entity3 . Here, our aims were to determine the importance of @entity1 in @entity5 elevation after @entity3 and whether mild @entity7 could prevent the @entity5 rise. @entity3 was performed in @entity2 . @entity5 was monitored and short-duration mild (35   C) or moderate (32.5   C) @entity7 , or normothermia (37   C) was induced after @entity3 onset. @entity1 was measured in three studies, using wet-dry weight calculations, T2-weighted magnetic resonance imaging, or histology. @entity5 increased 24 hours after @entity3 onset in all normothermic animals. Short-duration mild or moderate @entity7 prevented this rise. No correlation was seen between   @entity5 and @entity1 or @entity6 volumes. Calculated rates of @entity1 growth were orders of magnitude less than normal cerebrospinal fluid production rates. These data challenge current concepts and suggest that factors other than @entity8 are the primary cause of the @entity5 elevation 24 hours after @entity3 onset.

title: Intracranial pressure elevation after @entity4 in XXXX : @entity8 is not the only cause, and short-duration mild @entity7 is a highly effective preventive therapy.

answer: @entity2


abstract: @entity5 ( @entity5 ), an inducible form of the enzyme that catalyzes the first step in the synthesis of prostanoids, is associated with @entity3 , which is suspected to promote angiogenesis and tissue invasion of @entity2 and resistance to apoptosis. @entity5 is also involved in @entity1 and poor prognosis of @entity2 . @entity4 with @entity5 positivity is from 67 to 92  %. @entity5 -positive rate in metastatic lesions was greater than that of biopsy and/or resected samples of the primary site in @entity4 . And, what role does @entity5 play in @entity1 ? Genetic studies support a cause-effect connection between @entity5 and tumorigenesis. @entity5 expression had a poor prognosis with regard to @entity1 , and @entity0 with increased @entity5 expression in lung metastases died of the disease. @entity5 expression has also been established as a marker in @entity0 @entity4 , and @entity5 inhibition has been suggested as a possible way of improving therapeutic outcome. In addition, COX-inhibitors inhibit the @entity2 initiation, matrix metalloproteinases (MMPs), cell differentiation and T cell proliferation and suppression of the antitumor activity of natural killer cells and macrophages, angiogenic mechanism. Therefore, we can exert the COX-inhibitors to potentialize the effects of chemotherapeutic agents, and reverse the @entity1 in @entity4 to facilitate the @entity0 who may benefit from addition of COX-inhibitors to standard cytotoxic therapy.

title: Cyclooxygeanse-2 promotes @entity1 in XXXX .

answer: @entity4


abstract: @entity5 ( @entity5 ), an inducible form of the enzyme that catalyzes the first step in the synthesis of prostanoids, is associated with @entity3 , which is suspected to promote angiogenesis and tissue invasion of @entity2 and resistance to apoptosis. @entity5 is also involved in @entity1 and poor prognosis of @entity2 . @entity4 with @entity5 positivity is from 67 to 92  %. @entity5 -positive rate in metastatic lesions was greater than that of biopsy and/or resected samples of the primary site in @entity4 . And, what role does @entity5 play in @entity1 ? Genetic studies support a cause-effect connection between @entity5 and tumorigenesis. @entity5 expression had a poor prognosis with regard to @entity1 , and @entity0 with increased @entity5 expression in lung metastases died of the disease. @entity5 expression has also been established as a marker in @entity0 @entity4 , and @entity5 inhibition has been suggested as a possible way of improving therapeutic outcome. In addition, COX-inhibitors inhibit the @entity2 initiation, matrix metalloproteinases (MMPs), cell differentiation and T cell proliferation and suppression of the antitumor activity of natural killer cells and macrophages, angiogenic mechanism. Therefore, we can exert the COX-inhibitors to potentialize the effects of chemotherapeutic agents, and reverse the @entity1 in @entity4 to facilitate the @entity0 who may benefit from addition of COX-inhibitors to standard cytotoxic therapy.

title: Cyclooxygeanse-2 promotes XXXX in @entity4 .

answer: @entity1


abstract: OBJECTIVE: To investigate the risk for @entity2 associated with @entity1 in pregnancies after a @entity4 ( @entity4 ), compared with @entity0 with no prior @entity4 . DESIGN: Multicentre retrospective cohort study. SETTING USA POPULATION: @entity0 with @entity4 between 1996 and 2006 were compared with two unexposed groups who had cervical biopsy or Pap test, without any other cervical procedure, in the same calendar year. METHODS: The first pregnancy progressing beyond 20  weeks of gestation in @entity0 with prior @entity4 was compared with pregnancy in @entity0 without @entity4 . Stratified analysis according to the presence or the absence of @entity1 during pregnancy was used to investigate whether the risk for @entity2 differed according to the presence or the absence of @entity1 . The interaction between @entity4 and @entity1 was investigated using multivariable logistic regression with interaction terms, as well as the Mantel-Haenszel test for homogeneity. MAIN OUTCOME MEASURES: Spontaneous @entity2 (<37 and <34  weeks of gestation). RESULTS: Of 1727 @entity0 who met the inclusion criteria, 34.4% (n  =  598) underwent @entity4 prior to an index pregnancy. There was no increased risk for @entity1 among @entity0 with @entity4 compared with @entity0 without @entity4 . @entity3 and @entity4 demonstrated significant interaction, suggesting that the presence of @entity3 in @entity0 with a history of @entity4 augments the risk for @entity2 , compared with @entity0 with no history of @entity4 . CONCLUSIONS: @entity1 during pregnancy in @entity0 with a history of @entity4 may be associated with an increased risk for @entity2 , compared with @entity0 with no history of @entity4 .

title: Loop electrosurgical excision procedure and risk of XXXX during pregnancy: an observational study.

answer: @entity1


abstract: There have been a few studies reporting the epidemiology of @entity1 in Korea. Previous studies revealed relatively high prevalence and incidence of @entity1 in Korea and Japan. This study was designed to provide the latest epidemiologic information of @entity1 in Korea. We analyzed a database comprising of 50 million @entity0 covered in Korea by the National Health Insurance Service to calculate the prevalence. The incidence was estimated by eliminating the duplicated records of previous 3 years. We summarized the prevalence and incidence according to age, sex, and local distribution. In addition, the chronological changes were demonstrated with direct standardization using the 2010 population structure information. The standardized prevalence was 6.5 per 100000 @entity0 in 2005, which was increased to 18.1 in 2013. In the same period, standardized incidence was increased from 2.7 to 4.3 per 100000 @entity0 . The prevalence for @entity0 was 4.9 and 8.3 for @entity0 in 2005. In 2013, the prevalence had increased for @entity0 and @entity0 to 13.8 and 25.3, respectively. The incidence for @entity0 and @entity0 was 2.2 and 3.2, respectively, in 2005. It had increased to 3.5 and 5.7, respectively. The mean age of @entity0 was 33.5 in 2005 and increased to 42.5 in 2013. The peak prevalent age group had shifted slightly to the older age groups, with chronologically consistent female predominance. The prevalence was highest in Jeollabuk province and lowest in Ulsan city.

title: Epidemiology of XXXX in Korea: Based on National Health Insurance Service Data.

answer: @entity1


abstract: The fixation of gamma-rays induced @entity0 ( @entity0 ) caused after treatment either with beta-araA or in medium made hypertonic by the addition of @entity2 was studied in plateau phase @entity3 V79 cells. Treatment with beta-araA was found to affect a sector of @entity0 , the fixation of which specifically reduced the shoulder width of the survival curve. The effect was maximized when cell survival reached levels corresponding to an exponential line, with a slope similar to the final slope of the survival curve of untreated cells. This effect was achieved by a four hour treatment with beta-araA at concentrations above 150 microM. Longer treatment times or incubation at higher beta-araA concentrations did not significantly enhance the effect. Treatment in hypertonic medium, on the other hand, enhanced cell killing in a concentration dependent ( @entity1 -concentration) way and the survival reached values much lower than those corresponding to an exponential line. No indication for a plateau in the effect, indicating complete fixation of the sector of @entity0 that reacts sensitively to this treatment, was obtained. Both the slope and the shoulder width of the survival curve were affected, the slope first being increased after short treatment times (up to 10 min), followed by a decrease in the shoulder width after longer treatment times (longer than 10 min). Lesions fixed after treatment with beta-araA were repaired within four hours, whereas the repair of lesions fixed after treatment in hypertonic medium (460 mM @entity1 , 30 min) appeared to be biphasic, with a fast component (completed in about one hour) correlated with a decrease in the slope and a slow component (completed in four hours) correlated with restoration of the shoulder width. Based on these results, we suggest that two types of @entity0 may be induced in plateau phase V79 cells after exposure to gamma-rays. One, the repair of which is completed within about one hour and which affects the slope of the survival curve, and a second, the repair of which takes place in a few hours and which specifically affects the survival curve shoulder width. The terms beta- @entity0 and alpha- @entity0 are suggested for the first and second component, respectively. Comparison of the repair rates of alpha- @entity0 as measured with the help of beta-araA and of sublethal damage as measured in split-dose experiments indicated that these two cellular repair processes have very similar kinetics when measured under the same experimental conditions.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Evidence for the induction of two types of potentially lethal damage after exposure of plateau phase XXXX V79 cells to gamma-rays.

answer: @entity3


abstract: Background. Comorbidities are conditions that occur simultaneously but independently of another disorder. Among @entity2 @entity0 , comorbidities are common and may influence management. Objective. We compared comorbidity assessment by traditional @entity1 ( @entity1 ) and by standardized @entity0 -reported questionnaire based on the Adult Comorbidity Evaluation-27 (ACE-27). Methods. Between September 2011 and October 2013, @entity2 @entity0 underwent prospective comorbidity assessment by a Mohs surgeon ( @entity1 ) and a radiation oncologist (using a standardized @entity0 -reported questionnaire based on the ACE-27, the PRACE-27). Comorbidities were identified and graded according to the ACE-27 and compared for agreement. Results. Forty-four @entity0 were evaluated. @entity1 and PRACE-27 identified comorbidities in 79.5% and 88.6% (p = 0.12) of @entity0 , respectively. Among 27 comorbid ailments, the @entity1 identified 9.9% as being present, while the PRACE-27 identified 12.5%. When there were discordant observations, PRACE-27 was more likely than @entity1 to identify the comorbidity (OR = 5.4, 95% CI = 2.4-14.4, p < 0.001). Overall comorbidity scores were moderate or severe in 43.2% ( @entity1 ) versus 59.1% (PRACE-27) (p = 0.016). Limitations. Small sample size from a single institution. Conclusion. Comorbidities are common in @entity2 @entity0 , and a standardized questionnaire may better identify and grade them. More accurate comorbidity assessments may help guide @entity2 management.

title: Comorbidity Assessment in XXXX @entity0 : A Pilot Study Comparing Medical Interview with a @entity0 -Reported Questionnaire.

answer: @entity2


abstract: Background. Comorbidities are conditions that occur simultaneously but independently of another disorder. Among @entity2 @entity0 , comorbidities are common and may influence management. Objective. We compared comorbidity assessment by traditional @entity1 ( @entity1 ) and by standardized @entity0 -reported questionnaire based on the Adult Comorbidity Evaluation-27 (ACE-27). Methods. Between September 2011 and October 2013, @entity2 @entity0 underwent prospective comorbidity assessment by a Mohs surgeon ( @entity1 ) and a radiation oncologist (using a standardized @entity0 -reported questionnaire based on the ACE-27, the PRACE-27). Comorbidities were identified and graded according to the ACE-27 and compared for agreement. Results. Forty-four @entity0 were evaluated. @entity1 and PRACE-27 identified comorbidities in 79.5% and 88.6% (p = 0.12) of @entity0 , respectively. Among 27 comorbid ailments, the @entity1 identified 9.9% as being present, while the PRACE-27 identified 12.5%. When there were discordant observations, PRACE-27 was more likely than @entity1 to identify the comorbidity (OR = 5.4, 95% CI = 2.4-14.4, p < 0.001). Overall comorbidity scores were moderate or severe in 43.2% ( @entity1 ) versus 59.1% (PRACE-27) (p = 0.016). Limitations. Small sample size from a single institution. Conclusion. Comorbidities are common in @entity2 @entity0 , and a standardized questionnaire may better identify and grade them. More accurate comorbidity assessments may help guide @entity2 management.

title: Comorbidity Assessment in @entity2 XXXX : A Pilot Study Comparing Medical Interview with a @entity0 -Reported Questionnaire.

answer: @entity0


abstract: Background. Comorbidities are conditions that occur simultaneously but independently of another disorder. Among @entity2 @entity0 , comorbidities are common and may influence management. Objective. We compared comorbidity assessment by traditional @entity1 ( @entity1 ) and by standardized @entity0 -reported questionnaire based on the Adult Comorbidity Evaluation-27 (ACE-27). Methods. Between September 2011 and October 2013, @entity2 @entity0 underwent prospective comorbidity assessment by a Mohs surgeon ( @entity1 ) and a radiation oncologist (using a standardized @entity0 -reported questionnaire based on the ACE-27, the PRACE-27). Comorbidities were identified and graded according to the ACE-27 and compared for agreement. Results. Forty-four @entity0 were evaluated. @entity1 and PRACE-27 identified comorbidities in 79.5% and 88.6% (p = 0.12) of @entity0 , respectively. Among 27 comorbid ailments, the @entity1 identified 9.9% as being present, while the PRACE-27 identified 12.5%. When there were discordant observations, PRACE-27 was more likely than @entity1 to identify the comorbidity (OR = 5.4, 95% CI = 2.4-14.4, p < 0.001). Overall comorbidity scores were moderate or severe in 43.2% ( @entity1 ) versus 59.1% (PRACE-27) (p = 0.016). Limitations. Small sample size from a single institution. Conclusion. Comorbidities are common in @entity2 @entity0 , and a standardized questionnaire may better identify and grade them. More accurate comorbidity assessments may help guide @entity2 management.

title: Comorbidity Assessment in @entity2 @entity0 : A Pilot Study Comparing Medical Interview with a XXXX -Reported Questionnaire.

answer: @entity0


abstract: This study examines the accuracy of @entity2 radioimmunodetection. Twenty-seven @entity0 with a history of histologically-confirmed @entity3 received a high-titer, purified goat anti- @entity4 IgG labelled with 131-I at a total dose of at least 1.0 muCi. Various body views were scanned at 24 and 48 hours after administration of the radioantibody. Three additional cases were evaluated; one had a @entity5 in the rectum and received the 131-I-labelled anti- @entity4 IgG, while two @entity3 @entity0 received normal goat IgG labelled with 131-I. All of the 7 cases with primary @entity2 showed true-positive @entity1 localization, while 20 of 25 sites of metastatic @entity2 detected by immune scintigraphy were corroborated by other detection measures. The sensitivity of the radioimmunodetection of @entity2 (primary and metastatic) was found to be 90% (true-positive rate), the putative specificity (true-negative rate) was 94%, and the appraent overall accuracy of the technique was 93%. Neither the case of a @entity5 receiving the anti- @entity4 IgG nor the two cases of @entity3 receiving normal goat IgG showed @entity1 radiolocalization. Very high circulating @entity4 titers did not appear to hinder successful @entity1 radiolocalization. These findings suggest that in @entity2 the method of @entity4 radioimmunodetection may be of value in preoperatively determining the location and extent of disease, in assessing possible recurrence or spread postoperatively, and in localizing the source of @entity4 production in @entity0 with rising or elevated @entity4 titers. An ancilliary benefit could be a more @entity1 -specific detection test for confirming the findings of other, more conventional diagnostic measures.

title: Radioimmunodetection of XXXX .

answer: @entity2


abstract: PURPOSE: We investigated the effect of PP-001, a new small molecule inhibitor of dihydro-orotate dehydrogenase in two experimental @entity0 experimental @entity1 (EAU) models: a spontaneously relapsing-remitting model and a monophasic/chronic disease model that results in late @entity5 . Both of the diseases are induced by immunization with autoantigen peptides. METHODS: Prevention was tested using daily oral applications of PP-001 after immunization with the @entity10 peptide PDSAg (for induction of monophasic @entity2 ) or the interphotoreceptor retinoid-binding protein peptide R14 (for induction of spontaneously relapsing-remitting EAU). Treatment to inhibit relapses and @entity3 was tested using PP-001 daily after the first attack of R14-induced or after onset of PDSAg-induced EAU. @entity2 was graded clinically and histologically. The effect of PP-001 on cytokine secretion and proliferation was evaluated using @entity0 T-cell lines. RESULTS: Preventive feeding of PP-001 abrogated both types of EAU. Starting treatment after the resolution of the first attack led to a significant reduction of the number and intensity of relapses in R14-induced EAU. PP-001-treatment initiated after onset or after peak of PDSAg-induced EAU significantly reduced @entity3 (as determined by histology). Proliferation of antigen-specific T-cell lines and secretion of IFN-y, @entity7 , @entity8 , @entity9 , and @entity6 were efficiently suppressed by PP-001. CONCLUSIONS: We investigated a new dihydroorotate dehydrogenase inhibitor as treatment for primary and recurrent disease in relapsing-remitting and chronic @entity0 models of experimental @entity1 . The small molecule compound PP-001 suppressed proliferation and cytokine secretion of autoreactive T cells (i.e., @entity4 , @entity7 , and @entity6 ) and @entity5 in chronic EAU.

title: A New Small Molecule For Treating Inflammation and Chorioretinal Neovascularization in Relapsing-Remitting and Chronic Experimental Autoimmune XXXX .

answer: @entity2


abstract: UNASSIGNED: Although @entity3 ( @entity3 ) show typical histomorphologic features, they sometimes remain difficult in distinction from benign adnexal @entity2 of follicular origin like @entity8 ( @entity8 ) or trichoblastoma (TB). Consequently, an immunohistochemical marker panel separating described entities would be helpful in clinical routine. Thus, we stained 22 @entity1 ( @entity3 , @entity8 , and TB) against @entity5 , @entity4 , @entity7 , @entity6 , and @entity6 . The staining pattern was described and quantified using an immunohistochemical score. Although @entity6 and @entity6 revealed a strong staining intensity of all @entity1 without distinction between @entity3 and benign lesions (P=1.000), established Merkel cell marker @entity4 illustrated a loss of staining in @entity3 compared with @entity8 and TB (P=0.007). In contrast, @entity3 exhibited an increased expression of @entity7 in relation to @entity8 and TB (P=0.009). Single application of @entity4 or @entity7 could predict diagnosis of @entity3 in 81.8% or 72.7%, respectively. Combining consecutive staining of @entity7 and @entity4 could even enhance specificity toward diagnosis of @entity8 or TB. Hence, findings of our study imply that sequential staining of @entity4 and @entity7 prevents false-positive classification of @entity3 . Furthermore, our study demonstrated that @entity6 exhibits the same staining pattern in @entity3 , @entity8 , and TB. Therefore, @entity6 might replace @entity6 equivalently establishing diagnosis of primary @entity0 of the skin in the form of @entity3 as well as benign @entity0 . As a result, the depicted immunohistochemical marker panel may be applied for @entity2 as a diagnostic adjunct especially in surgically challenging body regions.

title: XXXX in Conjunction With @entity4 and @entity7 Distinguishes Primary @entity0 of the Skin.

answer: @entity6


abstract: UNASSIGNED: Although @entity3 ( @entity3 ) show typical histomorphologic features, they sometimes remain difficult in distinction from benign adnexal @entity2 of follicular origin like @entity8 ( @entity8 ) or trichoblastoma (TB). Consequently, an immunohistochemical marker panel separating described entities would be helpful in clinical routine. Thus, we stained 22 @entity1 ( @entity3 , @entity8 , and TB) against @entity5 , @entity4 , @entity7 , @entity6 , and @entity6 . The staining pattern was described and quantified using an immunohistochemical score. Although @entity6 and @entity6 revealed a strong staining intensity of all @entity1 without distinction between @entity3 and benign lesions (P=1.000), established Merkel cell marker @entity4 illustrated a loss of staining in @entity3 compared with @entity8 and TB (P=0.007). In contrast, @entity3 exhibited an increased expression of @entity7 in relation to @entity8 and TB (P=0.009). Single application of @entity4 or @entity7 could predict diagnosis of @entity3 in 81.8% or 72.7%, respectively. Combining consecutive staining of @entity7 and @entity4 could even enhance specificity toward diagnosis of @entity8 or TB. Hence, findings of our study imply that sequential staining of @entity4 and @entity7 prevents false-positive classification of @entity3 . Furthermore, our study demonstrated that @entity6 exhibits the same staining pattern in @entity3 , @entity8 , and TB. Therefore, @entity6 might replace @entity6 equivalently establishing diagnosis of primary @entity0 of the skin in the form of @entity3 as well as benign @entity0 . As a result, the depicted immunohistochemical marker panel may be applied for @entity2 as a diagnostic adjunct especially in surgically challenging body regions.

title: @entity6 in Conjunction With XXXX and @entity7 Distinguishes Primary @entity0 of the Skin.

answer: @entity4


abstract: UNASSIGNED: Although @entity3 ( @entity3 ) show typical histomorphologic features, they sometimes remain difficult in distinction from benign adnexal @entity2 of follicular origin like @entity8 ( @entity8 ) or trichoblastoma (TB). Consequently, an immunohistochemical marker panel separating described entities would be helpful in clinical routine. Thus, we stained 22 @entity1 ( @entity3 , @entity8 , and TB) against @entity5 , @entity4 , @entity7 , @entity6 , and @entity6 . The staining pattern was described and quantified using an immunohistochemical score. Although @entity6 and @entity6 revealed a strong staining intensity of all @entity1 without distinction between @entity3 and benign lesions (P=1.000), established Merkel cell marker @entity4 illustrated a loss of staining in @entity3 compared with @entity8 and TB (P=0.007). In contrast, @entity3 exhibited an increased expression of @entity7 in relation to @entity8 and TB (P=0.009). Single application of @entity4 or @entity7 could predict diagnosis of @entity3 in 81.8% or 72.7%, respectively. Combining consecutive staining of @entity7 and @entity4 could even enhance specificity toward diagnosis of @entity8 or TB. Hence, findings of our study imply that sequential staining of @entity4 and @entity7 prevents false-positive classification of @entity3 . Furthermore, our study demonstrated that @entity6 exhibits the same staining pattern in @entity3 , @entity8 , and TB. Therefore, @entity6 might replace @entity6 equivalently establishing diagnosis of primary @entity0 of the skin in the form of @entity3 as well as benign @entity0 . As a result, the depicted immunohistochemical marker panel may be applied for @entity2 as a diagnostic adjunct especially in surgically challenging body regions.

title: @entity6 in Conjunction With @entity4 and @entity7 Distinguishes Primary XXXX of the Skin.

answer: @entity0


abstract: UNASSIGNED: Although @entity3 ( @entity3 ) show typical histomorphologic features, they sometimes remain difficult in distinction from benign adnexal @entity2 of follicular origin like @entity8 ( @entity8 ) or trichoblastoma (TB). Consequently, an immunohistochemical marker panel separating described entities would be helpful in clinical routine. Thus, we stained 22 @entity1 ( @entity3 , @entity8 , and TB) against @entity5 , @entity4 , @entity7 , @entity6 , and @entity6 . The staining pattern was described and quantified using an immunohistochemical score. Although @entity6 and @entity6 revealed a strong staining intensity of all @entity1 without distinction between @entity3 and benign lesions (P=1.000), established Merkel cell marker @entity4 illustrated a loss of staining in @entity3 compared with @entity8 and TB (P=0.007). In contrast, @entity3 exhibited an increased expression of @entity7 in relation to @entity8 and TB (P=0.009). Single application of @entity4 or @entity7 could predict diagnosis of @entity3 in 81.8% or 72.7%, respectively. Combining consecutive staining of @entity7 and @entity4 could even enhance specificity toward diagnosis of @entity8 or TB. Hence, findings of our study imply that sequential staining of @entity4 and @entity7 prevents false-positive classification of @entity3 . Furthermore, our study demonstrated that @entity6 exhibits the same staining pattern in @entity3 , @entity8 , and TB. Therefore, @entity6 might replace @entity6 equivalently establishing diagnosis of primary @entity0 of the skin in the form of @entity3 as well as benign @entity0 . As a result, the depicted immunohistochemical marker panel may be applied for @entity2 as a diagnostic adjunct especially in surgically challenging body regions.

title: @entity6 in Conjunction With @entity4 and XXXX Distinguishes Primary @entity0 of the Skin.

answer: @entity7


abstract: UNASSIGNED: @entity7 is a continuous pathological process that starts early in life and progresses frequently to unstable plaques. @entity5 leads to deleterious consequences such as @entity8 , @entity2 and atherothrombosis. The vulnerable lesion has several structural and functional hallmarks that distinguish it from the stable plaque. The unstable plaque has large @entity1 core (over 40% plaque volume) composed of @entity4 crystals, @entity9 , oxidized lipids, fibrin, erythrocytes and their remnants (haeme, @entity3 , haemoglobin), and dying macrophages. The fibrous cap is thin, depleted of smooth muscle cells and collagen, and is infiltrated with proinflammatory cells. In unstable lesion, formation of neomicrovessels is increased. These neovessels have weak integrity and leak thereby leading to recurrent @entity6 . @entity6 deliver erythrocytes to the @entity1 core where they degrade promoting @entity0 and oxidative stress. Inflammatory cells mostly presented by monocytes/macrophages, neutrophils and mast cells extravagate from bleeding neovessels and infiltrate adventitia where they support chronic @entity0 . Plaque destabilization is an evolutionary process that could start at early @entity7 stages and whose progression is influenced by many factors including neovascularization, intraplaque @entity6 , formation of @entity4 crystals, @entity0 , oxidative stress and intraplaque protease activity.

title: Contribution of neovascularization and intraplaque XXXX to @entity7 plaque progression and instability.

answer: @entity6


abstract: UNASSIGNED: @entity7 is a continuous pathological process that starts early in life and progresses frequently to unstable plaques. @entity5 leads to deleterious consequences such as @entity8 , @entity2 and atherothrombosis. The vulnerable lesion has several structural and functional hallmarks that distinguish it from the stable plaque. The unstable plaque has large @entity1 core (over 40% plaque volume) composed of @entity4 crystals, @entity9 , oxidized lipids, fibrin, erythrocytes and their remnants (haeme, @entity3 , haemoglobin), and dying macrophages. The fibrous cap is thin, depleted of smooth muscle cells and collagen, and is infiltrated with proinflammatory cells. In unstable lesion, formation of neomicrovessels is increased. These neovessels have weak integrity and leak thereby leading to recurrent @entity6 . @entity6 deliver erythrocytes to the @entity1 core where they degrade promoting @entity0 and oxidative stress. Inflammatory cells mostly presented by monocytes/macrophages, neutrophils and mast cells extravagate from bleeding neovessels and infiltrate adventitia where they support chronic @entity0 . Plaque destabilization is an evolutionary process that could start at early @entity7 stages and whose progression is influenced by many factors including neovascularization, intraplaque @entity6 , formation of @entity4 crystals, @entity0 , oxidative stress and intraplaque protease activity.

title: Contribution of neovascularization and intraplaque @entity6 to XXXX plaque progression and instability.

answer: @entity7


abstract: INTRODUCTION: Among non-ablative devices for @entity1 , @entity2 ( @entity2 ) has considerable effectiveness. It can penetrate to deep dermis due to its longer wavelength. This study assesses the efficacy and safety of @entity2 applying new parameters for skin rejuvenation in Korean subjects. METHODS: A prospective randomized split-faced study was done (n = 20). Half of the face was treated with three passes of @entity2 at a spot size of 12 mm, 20-24 J/cm(2) fluence, 12 ms width, and frequency of 2 Hz, for three sessions, every four weeks. Outcomes were measured by wrinkle evaluation of blinded investigators, subjects' self-assessment, objective measurements of elasticity, and skin biopsy. RESULTS: Four weeks after the final treatment sessions, the average wrinkle grades of the treated side were reduced by 45.1%. Skin elasticity was significantly increased. The increment of collagen and elastic fiber in papillary dermis was confirmed histologically. No adverse reaction was reported. @entity0 on the treated side was mild without needing anesthesia. DISCUSSION: The authors studied new parameters for @entity2 for improvement of wrinkles and @entity1 with fewer treatment sessions without serious complications. Histologic findings corresponded to clinical improvement. CONCLUSION: New parameters of @entity2 can achieve wrinkle improvement with few side effects.

title: Long pulsed 1064 nm Nd:YAG laser treatment for XXXX : evaluation of new parameters.

answer: @entity1


abstract: BACKGROUND: To the authors' knowledge, little is known regarding the rate at which @entity1 survivors successfully adopt a @entity0 or about their experiences negotiating a costly, and perhaps discriminatory, process regarding the prospective parent's health history. The current study describes the results of a learning activity in which nurses contacted an adoption agency to learn more about the process for survivors with the goal of helping nurses provide @entity0 with accurate information for making a well-informed decision regarding adoption. METHODS: Training program @entity0 identified an adoption agency (local, state, or international) and conducted an interview using a semistructured guide. After the interview, @entity0 created a summary of responses to the questions. The authors examined responses to each question using qualitative content analysis. RESULTS: A total of 77 @entity0 (98% completion rate) across 15 states provided a summary. Responses were distributed across the following categories: adoption costs, steps required for survivors seeking adoption, challenges for survivors seeking adoption, birth parents' reservations, and planned institutional changes to increase adoption awareness. The majority of respondents reported improving their knowledge of adoption and @entity1 , increased challenges for survivors, and the need to educate @entity0 concerning the realities of adoption policies. The need for a letter stating the survivor was 5 years @entity1 free was identified as a significant obstacle for survivors. CONCLUSIONS: Nurses are charged with following practice guidelines that include recommendations for appropriate reproductive health referrals. @entity1 survivors would benefit from a health care provider who can provide education and concrete information when @entity0 are making a decision about fertility and adoption. @entity1 2015;121:2993-3000.    2015 American @entity1 Society.

title: Adoption and XXXX survivors: Findings from a learning activity for oncology nurses.

answer: @entity1


abstract: @entity7 ( @entity7 ) is increasingly recognized as a common and devastating problem. Because @entity2 breathing is thought to play a critical role in these deaths, we sought to identify forebrain sites underlying @entity6 -evoked @entity9 in @entity0 . We took advantage of an extraordinary clinical opportunity to study a research @entity0 with medically intractable @entity4 who had extensive bilateral frontotemporal electrode coverage while breathing was monitored during @entity6 recorded by intracranial electrodes and mapped by high-resolution brain imaging. We found that central @entity5 and @entity10 desaturation occurred when @entity6 spread to the amygdala. In the same @entity0 , localized electrical stimulation of the amygdala reproduced the @entity5 and O2 desaturation. Similar effects of amygdala stimulation were observed in two additional subjects, including one without a @entity4 . The @entity0 were completely unaware of the @entity5 evoked by stimulation and expressed no @entity8 , despite being awake and vigilant. In contrast, @entity8 holding of similar duration caused severe @entity8 . These findings suggest a functional connection between the amygdala and medullary respiratory network in @entity0 . Moreover, they suggest that @entity6 spread to the amygdala may cause loss of spontaneous breathing of which @entity0 are unaware, and thus has potential to contribute to @entity7 . SIGNIFICANCE STATEMENT: @entity7 ( @entity7 ) is the most common cause of @entity3 in @entity0 with chronic @entity4 . Impaired breathing during and after @entity6 is common and suspected to play a role in @entity7 . Understanding the cause of this peri-ictal @entity9 may lead to preventative strategies. In @entity4 @entity0 , we found that @entity6 invasion of the amygdala co-occurred with @entity5 and @entity1 desaturation, and electrical stimulation of the amygdala reproduced these respiratory findings. Strikingly, the subjects were unaware of the @entity5 . These findings indicate a functional connection between the amygdala and brainstem respiratory network in @entity0 and suggest that amygdala @entity6 may cause loss of spontaneous breathing of which @entity0 are unaware-a combination that could be deadly.

title: Breathing Inhibited When XXXX Spread to the Amygdala and upon Amygdala Stimulation.

answer: @entity6


abstract: [Purpose] This study investigated the effects of a multifactorial fall prevention program on balance, gait, and fear of falling in @entity1 @entity0 . [Subjects] Twenty-five @entity1 @entity0 were divided randomly into multifactorial fall prevention program group (n=15) and control treadmill group (n=10). [Methods] All interventions were applied for 30   min, five times per week, for five weeks. The fall prevention program included interventions based on the "Step Up to Stop Falls" initiative and educational interventions based on the Department of Health guidelines. For those in the treadmill group, the speed was increased gradually. The Korean falls efficacy scale and Korean activities-specific balance confidence scale were used to assess fear of falling. To assess balance and walking ability, the Korean performance-oriented mobility assessment scale and the 10-m and 6-minute walk tests were used. [Results] The fall prevention program interventions were found to be very effective at improving gait, balance, and fear of falling compared with the treadmill intervention and therefore seem appropriate for @entity1 @entity0 . [Conclusion] A multifactorial fall prevention program is effective at improving balance, gait ability, and fear of falling. It is a more specific and broad intervention for reducing falls among inpatients in facilities and hospitals.

title: Effects of a multifactorial fall prevention program on balance, gait, and fear of falling in post- XXXX inpatients.

answer: @entity1


abstract: UNASSIGNED: Background. Polymicrogyric cortex demonstrates interindividual variation with regard to both extent of dyslamination and functional capacity. Given the relationship between laminar structure and white matter fibers, we sought to define the relationship between @entity5 ( @entity5 ), intrahemispheric association pathways, and network function. Methods. Each @entity3 ( @entity3 ) was categorized as present or absent. Language was characterized by a pediatric neurologist. The presence of @entity4 cortex in the expected anatomic locations of Broca's (BA) and @entity2 ( @entity2 ) was evaluated by two pediatric neuroradiologists blinded to DTI and language data. Results. 16 @entity5 @entity0 and 16 age/gender-matched controls were included. All normative controls had an identifiable left @entity3 . 6/7 @entity5 @entity0 with @entity4 cortex within BA and/or @entity2 had no left @entity3 ; @entity5 @entity0 without involvement of these regions had a lower frequency of absence of the left @entity3 (p < 0.006). All @entity0 without a left @entity3 had some degree of @entity1 . @entity5 @entity0 without a left @entity3 had a significantly greater frequency of @entity1 compared to those @entity5 @entity0 with a left @entity3 (p < 0.003). Conclusion. In @entity0 with @entity5 (1) the presence of @entity4 cortex within @entity2 and/or BA is associated with absence of the left @entity3 and (2) absence of the left @entity3 is associated with @entity1 .

title: Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric @entity0 with XXXX .

answer: @entity5


abstract: UNASSIGNED: Background. Polymicrogyric cortex demonstrates interindividual variation with regard to both extent of dyslamination and functional capacity. Given the relationship between laminar structure and white matter fibers, we sought to define the relationship between @entity5 ( @entity5 ), intrahemispheric association pathways, and network function. Methods. Each @entity3 ( @entity3 ) was categorized as present or absent. Language was characterized by a pediatric neurologist. The presence of @entity4 cortex in the expected anatomic locations of Broca's (BA) and @entity2 ( @entity2 ) was evaluated by two pediatric neuroradiologists blinded to DTI and language data. Results. 16 @entity5 @entity0 and 16 age/gender-matched controls were included. All normative controls had an identifiable left @entity3 . 6/7 @entity5 @entity0 with @entity4 cortex within BA and/or @entity2 had no left @entity3 ; @entity5 @entity0 without involvement of these regions had a lower frequency of absence of the left @entity3 (p < 0.006). All @entity0 without a left @entity3 had some degree of @entity1 . @entity5 @entity0 without a left @entity3 had a significantly greater frequency of @entity1 compared to those @entity5 @entity0 with a left @entity3 (p < 0.003). Conclusion. In @entity0 with @entity5 (1) the presence of @entity4 cortex within @entity2 and/or BA is associated with absence of the left @entity3 and (2) absence of the left @entity3 is associated with @entity1 .

title: Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric XXXX with @entity5 .

answer: @entity0