abstract: OBJECTIVE: Relatively little has been written about the outcomes of medical stabilization, analyzed specifically across the age spectrum, in adults with severe @entity4 ( @entity4 ). METHOD: We retrospectively evaluated clinical parameters relevant to acuity of illness and outcomes of early refeeding in 142 adults with severe @entity4 , admitted for definitive inpatient medical stabilization from October 1, 2008 to December 31, 2012. @entity0 were categorized into three age groups: 17 to 29, 30 to 40, and 41+ years. RESULTS: The study included 142 @entity0 with median age of 28 years old (range 17-65 years). Fifty-four percent (n = 78) were under 30 years old, 23% (n = 32) between 30 and 40 years old, and 23% (n = 32) were over 40 years old. Average admission BMI did not differ among age groups, ranging from 12.7 to 13.2 kg/m(2) . Of the admission parameters, only low serum @entity6 levels (more prevalent in older @entity0 ), high international normalized ratio (INR) levels (more prevalent in younger @entity0 ), and @entity5 (more prevalent in the <30 age group) varied with age. During hospitalization, rates of @entity3 , @entity7 , @entity2 , very low %IBW, refeeding @entity8 , refeeding @entity1 , length of stay, and discharge BMI did not differ with age. Age group was associated with rate of weekly weight gain only in @entity0 with @entity4 -binge purge subtype. DISCUSSION: Results demonstrate medical abnormalities and response to medical stabilization in severely ill @entity4 @entity0 during hospitalization were mostly similar across the age span. This information should allay fears that the effect of age will make medical stabilization more difficult.    2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015).

title: Medical outcomes for adults hospitalized with severe XXXX : An analysis by age group.

answer: @entity4


abstract: In @entity1 ( @entity1 ), the @entity0 brain is capable of producing motor commands, but appears to require greater than normal subjective effort, particularly for the more-affected side. What is the nature of this subjective effort and can it be altered? We used an isometric task in which @entity0 produced a goal force by engaging both arms, but were free to assign any fraction of that force to each arm. The @entity0 preferred their less-affected arm, but only in some directions. This preference was correlated with lateralization of signal-dependent noise: the direction of force for which the brain was less willing to assign effort to an arm was generally the direction for which that arm exhibited greater noise. Therefore, the direction-dependent noise in each arm acted as an implicit cost that discouraged use of that arm. To check for a causal relationship between noise and motor cost, we used bilateral transcranial direct current stimulation of the motor cortex, placing the cathode on the more-affected side and the anode on the less-affected side. This stimulation not only reduced the noise on the more-affected arm, it also increased the willingness of the @entity0 to assign force to that arm. In a 3 d double-blind study and in a 10 d repeated stimulation study, bilateral stimulation of the two motor cortices with cathode on the more-affected side reduced noise and increased the willingness of the @entity0 to exert effort. This stimulation also improved the clinical motor symptoms of the disease. SIGNIFICANCE STATEMENT: In @entity1 , @entity0 are less willing to assign force to their affected arm. Here, we find that this pattern is direction dependent: directions for which the arm is noisier coincide with directions for which the brain is less willing to assign force. We hypothesized that if we could reduce the noise on the affected arm, then we may increase the willingness for the brain to assign force to that arm. We found a way to do this via noninvasive cortical stimulation. In addition to reducing effort costs associated with the affected arm, the cortical stimulation also improved clinical motor symptoms of the disease.

title: Altering Effort Costs in XXXX with Noninvasive Cortical Stimulation.

answer: @entity1


abstract: This study investigates the presence of antibodies against food products in milk samples from 30 Guatemalan @entity0 of 3 different socioeconomic status: 10 rural poor, 10 urban poor, and 10 urban privileged. The 3 groups had varied dietary habits. Both the rural and urban poor mothers do not consume @entity1 's milk. Black beans are consumed more often by the urban groups while soy bean products are consumed by both rural and urban poor regularly. Milk samples were collected from the mothers. The volume of milk produced in a 24-hour period was estimated by weighing the @entity0 before and after every meal. The enzyme-linked immunosorbent assay (ELISA) described by Sohe-Akerlund et.al. was used in quantitating milk secretory immunoglobulin A (SIgA). A modification of the ELISA method was used to determine levels of specific IgA antibodies directed against @entity1 's milk, black beans and @entity3 . The Wilcoxon rank sum test was used in statistical analysis. Comparable amounts of SIgA were produced by the 3 groups of mothers in a 24-hour period (p0.1). The urban privileged mothers exhibited significantly higher antibody levels against @entity1 's milk (p0.01) and black beans (p0.05) compared to the other 2 groups. There were no differences in the level of anti-soybean antibodies among the 3 groups. The notion that antibodies found in the breast milk reflect the mother's intestinal antigenic experience is supported by this study. It has been suggested that anti-food protein antibodies contribute in the prevention of @entity2 . If so, @entity1 's milk fed among the rural and urban poor @entity0 may be expected to produce negative reactions. This negative reaction can be prevented by feeding the mother, before delivery, @entity1 's milk products to induce them to produce milk antibodies against @entity1 's milk.

title: Food antibodies in milk from Guatemalan XXXX .

answer: @entity0


abstract: INTRODUCTION: Despite widespread gains toward the 5th Millennium Development Goal (MDG), pro-rich inequalities in reproductive health (RH) and @entity1 ( @entity1 ) are pervasive throughout the world. As countries enter the post-MDG @entity2 and strive toward UHC, it will be important to monitor the extent to which countries are achieving equity of RH and @entity1 service coverage. This study explores how equity of service coverage differs across countries, and explores what policy factors are associated with a country's progress, or lack thereof, toward more equitable RH and @entity1 service coverage. METHODS: We used RH and @entity1 service coverage data from Demographic and Health Surveys (DHS) for 74 countries to examine trends in equity between countries and over time from 1990 to 2014. We examined trends in both relative and absolute equity, and measured relative equity using a concentration index of coverage data grouped by wealth quintile. Through multivariate analysis we examined the relative importance of policy factors, such as political commitment to health, governance, and the level of prepayment, in determining countries' progress toward greater equity in RH and @entity1 service coverage. RESULTS: Relative equity for the coverage of RH and @entity1 services has continually increased across all countries over the past quarter century; however, inequities in coverage persist, in some countries more than others. Multivariate analysis shows that higher education and greater political commitment (measured as the share of government spending allocated to health) were significantly associated with higher equity of service coverage. Neither country income, i.e., @entity0 per capita, nor better governance were significantly associated with equity. CONCLUSION: Equity in RH and @entity1 service coverage has improved but varies considerably across countries and over time. Even among the subset of countries that are close to achieving the MDGs, progress made on equity varies considerably across countries. Enduring disparities in access and outcomes underpin mounting support for targeted reforms within the broader context of universal health coverage (UHC).

title: Did Equity of Reproductive and Maternal Health Service Coverage Increase during the MDG XXXX ? An Analysis of Trends and Determinants across 74 Low- and Middle-Income Countries.

answer: @entity2


abstract: INTRODUCTION: The accurate prediction of the risk of @entity3 ( @entity3 ) in @entity2 ( @entity2 ) remains elusive. Corrected QT interval (QTc) duration is a known risk factor in various cardiac conditions. Single nucleotide polymorphisms (SNPs) have been linked to @entity7 , and to @entity3 . Here we investigated the role of 21 candidate SNPs in QTc duration and @entity3 events in @entity0 with @entity2 . METHODS AND RESULTS: This @entity2 registry-based study included @entity0 with an ECG, medical history, first @entity3 event data, and DNA available. Each individual SNP was assessed using logistic regression for associations with 2 outcomes: a prolonged QTc ( >= 440 milliseconds), and first @entity3 event ( @entity3 , resuscitated @entity5 , and appropriate @entity1 ( @entity1 ) shock for @entity6 / @entity4 (VF/VT). In 272 @entity2 @entity0 , there were 31 @entity3 events (8 @entity3 , 9 resuscitated @entity5 , 14 @entity1 shocks for VF/VT; 11%). A QTc >=  500 milliseconds was associated with @entity3 events on multivariate analysis (odds ratio [OR] = 4.0, 95% confidence interval [CI], 1.19-12.02, P = 0.016). In 228 Caucasian @entity0 , 2 SNPs in the @entity8 gene ( @entity10 and @entity9 ) were associated with a prolonged QTc after correction for multiple testing. This remained significant after adjustment for current age, sex, and >= 1 @entity3 risk factor (OR 1.59 per copy of the minor allele, 95% CI 1.08-2.39, P = 0.022, and OR 1.63, 95% CI 1.09-2.49, P = 0.020, respectively). No SNPs were directly associated with @entity3 events. CONCLUSION: SNPs in the @entity8 gene influence QTc interval duration but we have not demonstrated a direct association with the risk of @entity3 .

title: @entity8 Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in XXXX .

answer: @entity2


abstract: INTRODUCTION: The accurate prediction of the risk of @entity3 ( @entity3 ) in @entity2 ( @entity2 ) remains elusive. Corrected QT interval (QTc) duration is a known risk factor in various cardiac conditions. Single nucleotide polymorphisms (SNPs) have been linked to @entity7 , and to @entity3 . Here we investigated the role of 21 candidate SNPs in QTc duration and @entity3 events in @entity0 with @entity2 . METHODS AND RESULTS: This @entity2 registry-based study included @entity0 with an ECG, medical history, first @entity3 event data, and DNA available. Each individual SNP was assessed using logistic regression for associations with 2 outcomes: a prolonged QTc ( >= 440 milliseconds), and first @entity3 event ( @entity3 , resuscitated @entity5 , and appropriate @entity1 ( @entity1 ) shock for @entity6 / @entity4 (VF/VT). In 272 @entity2 @entity0 , there were 31 @entity3 events (8 @entity3 , 9 resuscitated @entity5 , 14 @entity1 shocks for VF/VT; 11%). A QTc >=  500 milliseconds was associated with @entity3 events on multivariate analysis (odds ratio [OR] = 4.0, 95% confidence interval [CI], 1.19-12.02, P = 0.016). In 228 Caucasian @entity0 , 2 SNPs in the @entity8 gene ( @entity10 and @entity9 ) were associated with a prolonged QTc after correction for multiple testing. This remained significant after adjustment for current age, sex, and >= 1 @entity3 risk factor (OR 1.59 per copy of the minor allele, 95% CI 1.08-2.39, P = 0.022, and OR 1.63, 95% CI 1.09-2.49, P = 0.020, respectively). No SNPs were directly associated with @entity3 events. CONCLUSION: SNPs in the @entity8 gene influence QTc interval duration but we have not demonstrated a direct association with the risk of @entity3 .

title: XXXX Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in @entity2 .

answer: @entity8


abstract: OBJECTIVES: To determine the prevalence of @entity2 ( @entity2 ) among parents of Lebanese @entity0 with @entity1 and to investigate the associated stressors and coping strategies. METHODS: A cross-sectional study conducted at the American University of Beirut Medical Center- @entity0 Cancer Center of Lebanon in 2012. Parents of all @entity0 with @entity1 admitted for treatment were eligible @entity0 . The General Health Questionnaire (GHQ-12) was used to estimate the prevalence of @entity2 . Coping strategies were measured via the @entity4 ( @entity4 ). Bivariate and multiple regression analyses were conducted to evaluate the relationship between GHQ-12 (scores 0-36), stressors, family/social support, and coping strategies. RESULTS: One hundred fourteen parents (68.2%) completed the anonymous questionnaire. Based on GHQ-12, significant @entity2 was considered among 56.0% of the parents. It was found to be significantly positively associated with the degree of family financial problems and significantly negatively associated with the @entity0 's disease duration. A significant negative relationship was also found between @entity2 and Coping ( @entity4 ) scale, coping pattern I (Maintaining Family Integration and an Optimistic Outlook for the Situation), pattern II (Seeking Social Support), yet not with pattern III (Seeking Information). CONCLUSIONS: @entity2 is prevalent among parents of Lebanese @entity0 hospitalized because of @entity1 . Screening for @entity2 in the latter population is feasible, would identify those who are at risk for @entity3 , and facilitate the provision of support towards better adjustment and coping. Alleviating parental @entity2 may facilitate the realization of optimal health outcomes. Copyright    2015 John Wiley _ Sons, Ltd.

title: Psychological distress and coping strategies in parents of @entity0 with XXXX in Lebanon.

answer: @entity1


abstract: OBJECTIVES: To determine the prevalence of @entity2 ( @entity2 ) among parents of Lebanese @entity0 with @entity1 and to investigate the associated stressors and coping strategies. METHODS: A cross-sectional study conducted at the American University of Beirut Medical Center- @entity0 Cancer Center of Lebanon in 2012. Parents of all @entity0 with @entity1 admitted for treatment were eligible @entity0 . The General Health Questionnaire (GHQ-12) was used to estimate the prevalence of @entity2 . Coping strategies were measured via the @entity4 ( @entity4 ). Bivariate and multiple regression analyses were conducted to evaluate the relationship between GHQ-12 (scores 0-36), stressors, family/social support, and coping strategies. RESULTS: One hundred fourteen parents (68.2%) completed the anonymous questionnaire. Based on GHQ-12, significant @entity2 was considered among 56.0% of the parents. It was found to be significantly positively associated with the degree of family financial problems and significantly negatively associated with the @entity0 's disease duration. A significant negative relationship was also found between @entity2 and Coping ( @entity4 ) scale, coping pattern I (Maintaining Family Integration and an Optimistic Outlook for the Situation), pattern II (Seeking Social Support), yet not with pattern III (Seeking Information). CONCLUSIONS: @entity2 is prevalent among parents of Lebanese @entity0 hospitalized because of @entity1 . Screening for @entity2 in the latter population is feasible, would identify those who are at risk for @entity3 , and facilitate the provision of support towards better adjustment and coping. Alleviating parental @entity2 may facilitate the realization of optimal health outcomes. Copyright    2015 John Wiley _ Sons, Ltd.

title: Psychological distress and coping strategies in parents of XXXX with @entity1 in Lebanon.

answer: @entity0


abstract: INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute @entity6 (AMI) or @entity2 ( @entity2 ). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). METHODS: Between February 2009 and July 2012, 100 AMI and 50 @entity2 @entity0 were consecutively studied in three Spanish centres. @entity0 with previously documented @entity5 or @entity1 strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. @entity0 were followed for up to 6 months. NVE was defined as new @entity8 , transient @entity1 attack (TIA), @entity2 , or any hospitalization or @entity4 from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid @entity3 ( @entity3 ), @entity7 burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. RESULTS: During follow-up, 19 @entity0 (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 @entity4 ). Vascular events were associated with age (P = 0.039), carotid @entity3 >= 0.9 (P = 0.044), and EPC count (P = 0.041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10.33, 95%CI (1.22-87.34), P = 0.032] and @entity3 >= 0.9 [HR: 4.12, 95%CI (1.21-13.95), P = 0.023]. CONCLUSIONS: Basal EPC and @entity3 >= 0.9 can predict future vascular events in @entity0 with AMI and @entity2 , but CEC count does not affect cardiovascular risk.

title: Endothelial Progenitor Cells Predict Cardiovascular Events after XXXX and Acute @entity6 . A PROCELL Substudy.

answer: @entity2


abstract: INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute @entity6 (AMI) or @entity2 ( @entity2 ). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). METHODS: Between February 2009 and July 2012, 100 AMI and 50 @entity2 @entity0 were consecutively studied in three Spanish centres. @entity0 with previously documented @entity5 or @entity1 strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. @entity0 were followed for up to 6 months. NVE was defined as new @entity8 , transient @entity1 attack (TIA), @entity2 , or any hospitalization or @entity4 from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid @entity3 ( @entity3 ), @entity7 burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. RESULTS: During follow-up, 19 @entity0 (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 @entity4 ). Vascular events were associated with age (P = 0.039), carotid @entity3 >= 0.9 (P = 0.044), and EPC count (P = 0.041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10.33, 95%CI (1.22-87.34), P = 0.032] and @entity3 >= 0.9 [HR: 4.12, 95%CI (1.21-13.95), P = 0.023]. CONCLUSIONS: Basal EPC and @entity3 >= 0.9 can predict future vascular events in @entity0 with AMI and @entity2 , but CEC count does not affect cardiovascular risk.

title: Endothelial Progenitor Cells Predict Cardiovascular Events after @entity2 and Acute XXXX . A PROCELL Substudy.

answer: @entity6


abstract: BACKGROUND: Neonatal overfeeding induced by litter size reduction leads to further @entity0 and other @entity2 , such as liver oxidative stress and microesteatosis at adulthood. We hypothesized that overfeeding cause an early redox unbalance at weaning, which could program the animals to future @entity3 . Thus, we studied lipogenesis, adipogenesis, @entity8 status and oxidative balance in weaned overfed pups. METHODS: To induce early overfeeding, litters were adjusted to 3 pups at the 3(rd) day of lactation (SL group). The control group remained with 10 pups per litter until weaning (NL group). The peripheral autonomic nerve function was determined in vivo at 21 days-old. Thereafter, pups were killed for further analysis. Significant differences had P  <  0.05. RESULTS: The SL pups presented higher visceral adipocyte area, higher content of lipogenic enzymes (ACC, @entity10 ) with lower content of adipogenic factors ( @entity11 , PPARy) in visceral adipose tissue (VAT). Although the autonomic nerve activity and adrenal @entity6 production were not significantly altered, @entity8 receptor (b3ADR) was lower in VAT. They presented higher @entity4 , PPARy, @entity7 and @entity9 contents in liver. In plasma and liver, the SL pups showed an oxidative unbalance, with higher lipid peroxidation and protein oxidation. The SL group presented higher serum ALT. CONCLUSION: The early increased lipogenesis at adipose tissue and liver in weaned overfed @entity1 , suggest that the higher oxidative stress and lower @entity8 effect in VAT is associated with the early development of @entity3 and adipocyte @entity5 . This article is protected by copyright. All rights reserved.

title: Early redox unbalance is associated with XXXX at weaning in overfed @entity1 .

answer: @entity3


abstract: BACKGROUND: Neonatal overfeeding induced by litter size reduction leads to further @entity0 and other @entity2 , such as liver oxidative stress and microesteatosis at adulthood. We hypothesized that overfeeding cause an early redox unbalance at weaning, which could program the animals to future @entity3 . Thus, we studied lipogenesis, adipogenesis, @entity8 status and oxidative balance in weaned overfed pups. METHODS: To induce early overfeeding, litters were adjusted to 3 pups at the 3(rd) day of lactation (SL group). The control group remained with 10 pups per litter until weaning (NL group). The peripheral autonomic nerve function was determined in vivo at 21 days-old. Thereafter, pups were killed for further analysis. Significant differences had P  <  0.05. RESULTS: The SL pups presented higher visceral adipocyte area, higher content of lipogenic enzymes (ACC, @entity10 ) with lower content of adipogenic factors ( @entity11 , PPARy) in visceral adipose tissue (VAT). Although the autonomic nerve activity and adrenal @entity6 production were not significantly altered, @entity8 receptor (b3ADR) was lower in VAT. They presented higher @entity4 , PPARy, @entity7 and @entity9 contents in liver. In plasma and liver, the SL pups showed an oxidative unbalance, with higher lipid peroxidation and protein oxidation. The SL group presented higher serum ALT. CONCLUSION: The early increased lipogenesis at adipose tissue and liver in weaned overfed @entity1 , suggest that the higher oxidative stress and lower @entity8 effect in VAT is associated with the early development of @entity3 and adipocyte @entity5 . This article is protected by copyright. All rights reserved.

title: Early redox unbalance is associated with @entity3 at weaning in overfed XXXX .

answer: @entity1


abstract: The present study was undertaken to evaluate the 24-hour periodicity in serum @entity1 levels subsequent to transecting the ascending serotonergic system or ablating the suprachiasmatic nuclei ( @entity2 ) of adult (185 g) female @entity0 . The ascending serotonergic system was transected at the level of the rostral mesencephalon using a 1.5 mm wide knife and the @entity2 was ablated with a modified @entity4  sz-Pupp knife. The effect of @entity3 ( @entity3 ) or @entity2 ablation on the circadian rhythm in nonstress serum @entity1 levels was assessed 45 days after surgery by measuring with radioimmunoassay the serum @entity1 concentration in serial blood samples obtained from the tail vein of lightly restrained rats. Serum @entity1 concentration in control and @entity3 animals showed circadian periodicity; peak levels occurred during the midafternoon, 4 h prior to the dark phase of the lighting regime (lights on at 4 a.m., off at 6 p.m.). The amplitude of the fluctuations of both groups varied markedly and were related to the estrous cycle. However, @entity3 animals showed a reduced amplitude in the rhythm. In controls peak @entity1 levels on days of proestrus and estrus were 15-20 times higher than on days of diestrus. In contrast, serum @entity1 levels in @entity2 -ablated @entity0 did not vary with a circadian periodicity but rather showed random, low amplitude fluctuations. Reproductive cyclicity was also abolished by @entity2 ablation, i.e., @entity2 -ablated @entity0 presented persistent vaginal cornification. These data indicate that circadian periodicity in serum @entity1 levels is not compromised by sectioning the ascending serotonergic fibers but is abolished after ablating the @entity2 .

title: Twenty-four hour pattern of XXXX levels in female @entity0 subjected to transection of the mesencephalic raphe or ablation of the suprachiasmatic nuclei.

answer: @entity1


abstract: The present study was undertaken to evaluate the 24-hour periodicity in serum @entity1 levels subsequent to transecting the ascending serotonergic system or ablating the suprachiasmatic nuclei ( @entity2 ) of adult (185 g) female @entity0 . The ascending serotonergic system was transected at the level of the rostral mesencephalon using a 1.5 mm wide knife and the @entity2 was ablated with a modified @entity4  sz-Pupp knife. The effect of @entity3 ( @entity3 ) or @entity2 ablation on the circadian rhythm in nonstress serum @entity1 levels was assessed 45 days after surgery by measuring with radioimmunoassay the serum @entity1 concentration in serial blood samples obtained from the tail vein of lightly restrained rats. Serum @entity1 concentration in control and @entity3 animals showed circadian periodicity; peak levels occurred during the midafternoon, 4 h prior to the dark phase of the lighting regime (lights on at 4 a.m., off at 6 p.m.). The amplitude of the fluctuations of both groups varied markedly and were related to the estrous cycle. However, @entity3 animals showed a reduced amplitude in the rhythm. In controls peak @entity1 levels on days of proestrus and estrus were 15-20 times higher than on days of diestrus. In contrast, serum @entity1 levels in @entity2 -ablated @entity0 did not vary with a circadian periodicity but rather showed random, low amplitude fluctuations. Reproductive cyclicity was also abolished by @entity2 ablation, i.e., @entity2 -ablated @entity0 presented persistent vaginal cornification. These data indicate that circadian periodicity in serum @entity1 levels is not compromised by sectioning the ascending serotonergic fibers but is abolished after ablating the @entity2 .

title: Twenty-four hour pattern of @entity1 levels in female XXXX subjected to transection of the mesencephalic raphe or ablation of the suprachiasmatic nuclei.

answer: @entity0


abstract: UNASSIGNED: @entity1 are a major health issue associated with @entity1 . To surmount this issue, we developed @entity4 foams (PUFs) incorporating varying amounts of recombinant @entity0 epidermal growth factor (rhEGF) (rhEGF-PUFs) as a wound dressing for @entity1 . From electron microscopy images, it was found that the pore size of the rhEGF-PUFs surface (the wound contact layer) was less than 100 m, regardless of rhEGF content. The release of rhEGF from the PUFs was evaluated using an enzyme-linked immunosorbent assay. The result showed that the release of rhEGF was time and concentration dependent, i.e., the amount of released rhEGF significantly increased as the immersion time and the rhEGF content of the PUFs increased. In vitro @entity3 testing showed that rhEGF-PUFs increased the viability of HaCaT @entity0 keratinocytes and CCD986-sk @entity0 fibroblasts, which indicated that the incorporated rhEGF maintained its biological activity. In an in vitro scratch wound healing assay, the wound closure rate was faster in CCD986-sk @entity0 fibroblasts than in HaCaT @entity0 keratinocytes. Finally, the rhEGF-PUFs were evaluated as an in vivo treatment in a full-thickness wound model in diabetized @entity2 . The result indicated that compared with PUFs, rhEGF-PUFs accelerated wound healing by promoting wound contraction, re-epithelialization, collagen deposition and the formation of a skin appendage. These findings demonstrate that rhEGF-PUFs are a promising dressing for @entity1 .

title: @entity4 foam containing rhEGF as a dressing material for healing XXXX : Synthesis, characterization, in vitro and in vivo studies.

answer: @entity1


abstract: UNASSIGNED: @entity1 are a major health issue associated with @entity1 . To surmount this issue, we developed @entity4 foams (PUFs) incorporating varying amounts of recombinant @entity0 epidermal growth factor (rhEGF) (rhEGF-PUFs) as a wound dressing for @entity1 . From electron microscopy images, it was found that the pore size of the rhEGF-PUFs surface (the wound contact layer) was less than 100 m, regardless of rhEGF content. The release of rhEGF from the PUFs was evaluated using an enzyme-linked immunosorbent assay. The result showed that the release of rhEGF was time and concentration dependent, i.e., the amount of released rhEGF significantly increased as the immersion time and the rhEGF content of the PUFs increased. In vitro @entity3 testing showed that rhEGF-PUFs increased the viability of HaCaT @entity0 keratinocytes and CCD986-sk @entity0 fibroblasts, which indicated that the incorporated rhEGF maintained its biological activity. In an in vitro scratch wound healing assay, the wound closure rate was faster in CCD986-sk @entity0 fibroblasts than in HaCaT @entity0 keratinocytes. Finally, the rhEGF-PUFs were evaluated as an in vivo treatment in a full-thickness wound model in diabetized @entity2 . The result indicated that compared with PUFs, rhEGF-PUFs accelerated wound healing by promoting wound contraction, re-epithelialization, collagen deposition and the formation of a skin appendage. These findings demonstrate that rhEGF-PUFs are a promising dressing for @entity1 .

title: XXXX foam containing rhEGF as a dressing material for healing @entity1 : Synthesis, characterization, in vitro and in vivo studies.

answer: @entity4


abstract: Physical and @entity0 cause different patterns of changes in the fluorescence intensity of nigral and tuberoinfundibular DA neurons which point to changes in neuronal activity. In order to investigate possible interactions between @entity1 (alpha-melanotropin) and DA systems in stress, systemic and intraventricular injections of antiserum against @entity1 were made. The functional state of DA neurons was assessed by histochemical microfluorimetry and hormone levels were measured by radioimmunossay. Antiserum against @entity1 was found to affect the functional state of DA neurons, but only thorugh the intravenous route. Under physical stress i.v. injection of antiserum against @entity1 was accompanied by elevated levels of activity of the DA neurons of the substantia nigra. An intraventricular injection of the same antiserum was ineffective. In @entity0 , an effect was again seen only after intravenous injection of antiserum against @entity1 . In this situation, the activity in DA cell groups of the substantia nigra, ventral tegmental area and tubero-infundibular system was increased after antiserum injection. Possible influences from manipulations were checked; certain effects which depended upon experimental situation were noted. Our data suggest a modulatory influence of circulating @entity1 on the functional state of central DA systems.

title: Neuroendocrine regulation and central dopamine (DA) systems in physical and XXXX .

answer: @entity0


abstract: OBJECTIVES: With growing evidence for the effectiveness of craniosacral therapy (CST) for @entity2 management, the efficacy of CST remains unclear. This study therefore aimed at investigating CST in comparison with sham treatment in chronic nonspecific @entity4 @entity0 . MATERIALS AND METHODS: A total of 54 blinded @entity0 were randomized into either 8 weekly units of CST or light-touch sham treatment. Outcomes were assessed before and after treatment (week 8) and again 3 months later (week 20). The primary outcome was the @entity2 intensity on a visual analog scale at week 8; secondary outcomes included @entity2 on movement, pressure @entity2 sensitivity, functional disability, health-related quality of life, well-being, @entity1 , @entity3 , stress perception, @entity2 acceptance, body awareness, @entity0 ' global impression of improvement, and safety. RESULTS: In comparison with sham, CST @entity0 reported significant and clinically relevant effects on @entity2 intensity at week 8 (-21 mm group difference; 95% confidence interval, -32.6 to -9.4; P=0.001; d=1.02) and at week 20 (-16.8 mm group difference; 95% confidence interval, -27.5 to -6.1; P=0.003; d=0.88). Minimal clinically important differences in @entity2 intensity at week 20 were reported by 78% within the CST group, whereas 48% even had substantial clinical benefit. Significant between-group differences at week 20 were also found for @entity2 on movement, functional disability, physical quality of life, @entity1 and @entity0 ' global improvement. @entity2 sensitivity and body awareness were significantly improved only at week 8. No serious adverse events were reported. DISCUSSION: CST was both specifically effective and safe in reducing @entity4 intensity and may improve functional disability and the quality of life up to 3 months after intervention.

title: Craniosacral Therapy for the Treatment of XXXX : A Randomized Sham-controlled Trial.

answer: @entity4


abstract: Serum prolactin (PRL) levels display regular patterns throughout the 4-day @entity0 estrous cycle. A morphometric analysis of mammotropes (PRL-sereting cells) in the anterior pituitary was performed in an effort to quantify some of the ultrastructural events occurring prior to and during the secretion of PRL throughout the estrous cycle. In this study, a systematic sampling protocol applicable to the @entity0 adenohypophysis was developed, which took into account the lack of synchrony in estrous cycles among the animals, the heterogeneity of the gland, and the number of cells required to yield a representative sample. These techniques were used to determine the cell, nuclear, nucleolar, and cytosol volumes, which were correlated with the changing levels of serum @entity1 and PRL and pituitary PRL. @entity1 concentrations rose during late diestrus-1 and continued rising in a pulsatile manner, reaching maximal levels during proestrus. The elevations of @entity2 were accompanied by increases in nucleolar and nuclear volumes. However, at early estrus and on the afternoon of diestrus-2, times at which it has been reported that @entity3 levels are elevated, there was a dampening effect and these volumes declined. During early diestrus-2, when @entity1 levels began to rise, there were increases in nucleolar, nuclear, cellular and cytosol volumes, as well as increases in pituitary PRL; but at late diestrus-2 there was a marked increase in nuclear and nucleolar volumes which was not accompanied by increases in cellular and cytosol volumes. During proestrus, two peaks of serum PRL were found, at 6 pm and 12 m, which were concomitant with increased nucleolar, nuclear and cellular volumes. The 6-pm proestrous peak of PRL was preceded by elevated pituitary PRL; however, the 12-m proestrous peak occurred when the pituitary PRL was minimal, even though nuclear and cellular volumes were elevated. This suggests that the 6-pm release of PRL was derived from previously synthesized and stored hormone, while the 12-m peak was the result of the immediate release of PRL, with little storage.

title: Intracellular dynamics in pituitary mammotropes throughout the XXXX estrous cycle. I. Morphometric methodology and hormonal correlations with cellular and nuclear volumes.

answer: @entity0


abstract: 1.0 g of the new broad spectrum @entity1 @entity3 -2 ws given i.m. to volunteers with varying renal function levels. Peak values of 40-50 microgram/ml were commonly observed in serum. The serum half-life was 1.1-1.5 h in normal renal function and increased to 7.0-17.0 h in @entity0 with inulin clearance values of 12-14 ml/min. There was an appreciable lag before apparent absorption. Absorption rates and protein binding were uninfluenced by renal function. The renal clearance of the @entity1 was less than the glomerular filtration rate. This may be due to either chemical instability of the compound such that it is inactivated before assay, or a substantial portion is changed (instability, metabolism) before excretion. A minor adjustment in dosage schedule is necessary in reduced renal function. Even @entity0 with an inulin clearance of 12-14 ml/min have urine concentrations which are of antibacterial interest, at least in acute @entity2 without anatomical or other particular problems.

title: Pharmacokinetics of the new broad spectrum XXXX @entity3 -2.

answer: @entity1


abstract: 1.0 g of the new broad spectrum @entity1 @entity3 -2 ws given i.m. to volunteers with varying renal function levels. Peak values of 40-50 microgram/ml were commonly observed in serum. The serum half-life was 1.1-1.5 h in normal renal function and increased to 7.0-17.0 h in @entity0 with inulin clearance values of 12-14 ml/min. There was an appreciable lag before apparent absorption. Absorption rates and protein binding were uninfluenced by renal function. The renal clearance of the @entity1 was less than the glomerular filtration rate. This may be due to either chemical instability of the compound such that it is inactivated before assay, or a substantial portion is changed (instability, metabolism) before excretion. A minor adjustment in dosage schedule is necessary in reduced renal function. Even @entity0 with an inulin clearance of 12-14 ml/min have urine concentrations which are of antibacterial interest, at least in acute @entity2 without anatomical or other particular problems.

title: Pharmacokinetics of the new broad spectrum @entity1 XXXX -2.

answer: @entity3


abstract: BACKGROUND: @entity1 was known to cause @entity3 and most commonly @entity4 ( @entity4 ). The aim of this study is to determine the prevalence of @entity1 associated @entity3 and to identify risk factors associated with development of @entity4 in @entity0 receiving @entity1 . METHODS: A retrospective cross-sectional study was conducted. Subjects who developed elated thyroid stimulating hormone (TSH) were compared with those who remained euthyroid with @entity1 treatment. Logistic regression and survival analysis were applied to identify the significant factors associated with @entity4 . RESULTS: The prevalence of @entity1 associated with @entity4 was 31.7  %. The significant risk factors associated with increased risk of @entity4 included being female, higher serum @entity1 level, concomitant use of @entity2 and use of antidepressant. Use of depot injection was associated with decreased risk of @entity4 . CONCLUSIONS: Use of depot and avoidance of @entity2 or antidepressant should be taken into account before starting @entity0 on @entity1 treatment. @entity5 replacement should be considered when @entity1 associated @entity4 was identified.

title: The impact of XXXX on thyroid function in Chinese psychiatric population.

answer: @entity1


abstract: Little is known about genetic changes in squamous differentiation of non-schistosomiasis-associated @entity1 . Therefore, we investigated pure @entity3 ( @entity3 ), squamous parts of mixed @entity2 with squamous differentiation (MIX) and mere @entity0 ( @entity0 ) for structural genetic differences. Tissue microarray slides (n = 29 @entity3 , n = 35 MIX and n = 23 @entity0 ) were analyzed by ZytoLight SPEC @entity4 / @entity5 /7/17 Quadruple Color Probe fluorescence-in-situ-hybridization (FISH) and DNA was investigated by comparative genomic hybridization (CGH) (n = 35 SqCCs, n = 40 MIX and n = 36 @entity0 ). By FISH the mean number of polysomic cells was lowest in @entity3 ( @entity5 P = 0.0498, CEN17 P = 0.0009). A slight tendency of lower copy numbers of chromosomes 3, 7 and 17 and higher numbers of the @entity4 -locus in @entity3 (P = 0.45) indicated less @entity0 cells in @entity3 compared to MIX and @entity0 . In CGH @entity3 showed the lowest mean number of aberrations per @entity0 ( @entity3 5.37 changes, MIX 6.75 and @entity0 7.64; P = 0.1754). Significant differences between the three groups were found for loss of chromosome 3p (P = 0.004), 6q (P = 0.028), 11p (P = 0.024) and gains of 5p (P = 0.020). Loss of 3p was more frequent in @entity3 (51.4%) than in MIX (37.5%) or @entity0 (13.9%). To conclude, SqCCs show less polysomy and genetic alterations than MIX and @entity0 . Loss of 3p is more frequent in @entity3 but there are no absolute specific alterations for each @entity0 group. Squamous parts of @entity0 show similar alterations than @entity0 and should be considered as further development of @entity0 , while pure @entity3 seem to be a separate @entity0 group.

title: Comparison of structural genetics of non-schistosoma-associated XXXX .

answer: @entity1


abstract: BACKGROUND: An extremely rare primary @entity2 occurring in left proximal femurs of a 47-year old female is reported. CASE REPORT: She had left @entity4 for three months in April 2004. Radiological examinations revealed that a translucent expansive lesion in the left greater trochanter. She received the curettage of lesion and bone graft surgery. Curettage specimens were diagnosed as @entity7 , considered to be metastatic. Five months late the lesion recurred. She underwent obturator neurotomy plus total hip replacement of left hip. A long-term of more than ten years follow-up showed there were no evidence of disease recurrence or @entity1 and no any signs of other @entity2 in her body. DISCUSSION: The @entity2 contained myoepithelial component with positive immunostain of @entity9 protein, @entity8 , CK-pan, and @entity6 , epithelial component confirmed by CK-pan, CK-LMW and cartilage, which indicated the @entity2 was a @entity2 . @entity5 , relative high mitosis index, cartilage consistent with grade I chordrosarcoma, focal @entity3 , and infiltration between trabeculae found in the @entity2 indicated that the @entity2 had a low grade malignant nature. During long-time follow-up there were no signs of any @entity2 found in the @entity0 , which strongly suggested that the @entity2 be a primary one.

title: Primary XXXX of bone: a case report.

answer: @entity7


abstract: UNASSIGNED: To understand the consequences of macromolecular crowding, studies have largely employed in vitro experiments with synthetic polymers assumed to be both pure and "inert". These polymers alter enzyme kinetics by excluding volume that would otherwise be available to the enzymes, substrates, and products. Presented here is evidence that other factors, in addition to excluded volume, must be considered in the interpretation of crowding studies with synthetic polymers. Dextran has a weaker effect on the Michaelis-Menten kinetic parameters of @entity1 @entity0 dehydrogenase (YADH) than its small molecule counterpart, @entity2 . For @entity2 , the decreased Vmax values directly correlate with slower translational diffusion and the decreased Km values likely result from enhanced substrate binding due to YADH stabilization. Because dextran is unable to stabilize YADH to the same extent as @entity2 , this polymer's ability to decrease Km is potentially due to the nonideality of the solution, a crowding-induced conformational change, or both. Chronoamperometry reveals that @entity2 and dextran have surprisingly similar @entity3 diffusion coefficients. Thus, the reduction in Vmax values for @entity2 is partially offset by an additional macromolecular crowding effect with dextran. Finally, this is the first report that supplier-dependent impurities in dextran affect the kinetic parameters of YADH. Taken together, our results reveal that caution should be used when interpreting results obtained with inert synthetic polymeric agents, as additional effects from the underlying monomer need to be considered.

title: Slowed Diffusion and Excluded Volume Both Contribute to the Effects of Macromolecular Crowding on XXXX Dehydrogenase Steady-State Kinetics.

answer: @entity0


abstract: Examination of a large autopsy material from @entity0 's hospitals in Leningrad for 1978-1979 established a very high relative frequency of @entity1 in fatal cases. Compared with previous years, there is a change in the ratio of different diseases: a decrease in the rate of well known and relatively readily diagnosed @entity7 and an increase in @entity4 and mycoplasmosis with less marked macroscopic features. Various acute @entity3 occurred more frequently (in 68.2% of deaths), @entity4 and mycoplasmosis being prevalent among them. @entity5 occurred less frequently. There was a significant proportion of intrauterine infections diagnosed in 26.6% of @entity0 , with mycoplasmosis and @entity4 (respiratory, herpes, @entity6 , etc.) being predominant. Mycoplasmosis may be important in the development of @entity2 . Other @entity1 are analysed, including those with the predominant involvement of the alimentary tract, central nervous system, etc. Combined infections are noted to be very important. The author's own data are compared with those from other reports presented at the 2nd All-Union Conference of Childhood Pathologists.

title: [Current infectious pathology in XXXX ].

answer: @entity0


abstract: OBJECTIVES: In injury conditions, myofibroblasts are induced to lay down matrix proteins and support the repair process. In this study, we investigated the role of myofibroblasts, particularly stellate cells, in the growth and regeneration of pancreatic b cells. METHODS: We used both in vitro and in vivo approaches to address whether stellate cells may promote the growth of b cells. RESULTS: Our experiments demonstrated that activated stellate cells support the proliferation of b cells in vitro. In vivo, mesenchymals surrounding the pancreatic islets are activated (induced to proliferate) in the islet regeneration model of @entity1 null @entity0 . These mesenchymals display markers of pancreatic stellate cells, such as @entity3 and to a lesser extent, smooth muscle actin a. We have shown previously that targeted b-cell deletion of @entity1 lead to a significant increase in total islet mass. This phenotype was accompanied by an increase in peri-islet mitotic activity, particularly in islets injured by @entity2 , a b cell-specific toxin. CONCLUSIONS: Together with the in vitro observations, our data, here, suggest that that these mesenchymal cells may support the regeneration of the islets. Identifying how the communication occurs may provide clinically relevant mechanism for inducing b-cell regeneration.

title: Crosstalk Between Activated Myofibroblasts and b Cells in Injured XXXX Pancreas.

answer: @entity0


abstract: BACKGROUND: The discovery of the mutation causing @entity1 ( @entity1 ) in 1993 allowed direct mutation analysis and predictive testing to identify currently unaffected carriers with a sensitivity and specificity of virtually 100%. OBJECTIVE: The present study was designed to comprehensively profile the @entity0 who sought predictive testing for @entity1 between 1993 and 2009 in our Huntington centre. METHODS: Using a retrospective design, we analysed the written documentation of the counselling sessions for all referrals for predictive mutation testing in this time span. Six hundred sixty-three individuals at risk for @entity1 requested predictive testing. Roughly half (n = 333) completed the protocol and received their test result. RESULTS: In general our findings are in accordance with other reports: most @entity0 share an a priori risk of 50% (91.1%); more females request testing (58.5%); and those who ask for the result are mostly in their 30 s (mean = 35.1 years). Of those at 50% or 25% prior risks, 47.4% and 22.7%, respectively, tested positive in accordance with the respective risk of inheriting @entity1 . Generally, more @entity0 with an affected mother than father sought genetic testing (52.5% versus 47.5%). Interestingly, this difference was especially evident in the group of females who finally withdrew from testing (59.1%, p = 0.040). @entity0 , in particular those who decided in favour of the test, were more often accompanied by their partner in the pre-test counselling session than vice versa (67.9% versus 44.7%, p = 0.003). On the other hand, significantly more @entity0 who were being tested did not have a companion in the pre-test session as compared with @entity0 who decided against the test (40.0% versus 25.7%, p = 0.012). During the first four years of predictive testing (1993   1996) more @entity0 completed the protocol and received their test result as in later years. Yet, in this early time span significantly fewer females finally decided in favour of the test (48.4%, p = 0.005). These findings are discussed longitudinally and in the context of the experience in other centres. CONCLUSIONS: We present new gender-specific aspects of decision-making for predictive @entity1 tests.

title: Genetic Counselling for Predictive Testing in XXXX in One Centre since 1993. Gender-Specific Aspects of Decision-Making.

answer: @entity1


abstract: OBJECTIVES: There is evidence that B lymphocytes play a role in the pathogenesis of @entity2 ( @entity4 ). Stimulatory autoantibodies targeting and activating normal @entity0 fibroblasts in vitro have been demonstrated in sera from @entity4 @entity0 . Rituximab is a monoclonal antibody which selectively targets and depletes @entity3 + B lymphocytes. We investigated the biological effects of rituximab in six @entity0 affected by @entity4 with severe skin involvement. METHODS: Six @entity0 with severe skin @entity1 , unresponsive to immunosuppressive treatment, were treated with 375 mg/m2 per week of intravenous rituximab for a total of four doses. Serum stimulatory autoantibodies to the PDGF receptor were detected. Fibroblast activation was evaluated in fibroblasts grown from skin biopsies performed at baseline and at months 3 and 6 post-treatment. The modified Rodnan's skin score, health assessment questionnaire (HAQ) and visual analogic scale (VAS) for global wellness and B lymphocyte count were performed monthly. RESULTS: A significant reduction of anti-PDGF receptor autoantibodies was observed in the serum of all @entity0 3 months after treatment. Fibroblasts showed a significant downregulation of type I collagen gene expression and of the intracellular signalling triggered by anti- @entity5 autoantibodies. A decrease of the skin score and an improvement of disability indexes matched with the in vitro results. A single course of rituximab reduced @entity4 fibroblast activation in vitro and the serum levels of anti- @entity5 stimulatory autoantibodies. CONCLUSIONS: These data provide further evidence of B-cell involvement in the pathogenesis of @entity4 . Targeting B cells may be a promising treatment for @entity4 @entity0 , and controlled clinical trials are warranted.

title: Reduced type I collagen gene expression by skin fibroblasts of @entity0 with XXXX after one treatment course with rituximab.

answer: @entity2


abstract: OBJECTIVES: There is evidence that B lymphocytes play a role in the pathogenesis of @entity2 ( @entity4 ). Stimulatory autoantibodies targeting and activating normal @entity0 fibroblasts in vitro have been demonstrated in sera from @entity4 @entity0 . Rituximab is a monoclonal antibody which selectively targets and depletes @entity3 + B lymphocytes. We investigated the biological effects of rituximab in six @entity0 affected by @entity4 with severe skin involvement. METHODS: Six @entity0 with severe skin @entity1 , unresponsive to immunosuppressive treatment, were treated with 375 mg/m2 per week of intravenous rituximab for a total of four doses. Serum stimulatory autoantibodies to the PDGF receptor were detected. Fibroblast activation was evaluated in fibroblasts grown from skin biopsies performed at baseline and at months 3 and 6 post-treatment. The modified Rodnan's skin score, health assessment questionnaire (HAQ) and visual analogic scale (VAS) for global wellness and B lymphocyte count were performed monthly. RESULTS: A significant reduction of anti-PDGF receptor autoantibodies was observed in the serum of all @entity0 3 months after treatment. Fibroblasts showed a significant downregulation of type I collagen gene expression and of the intracellular signalling triggered by anti- @entity5 autoantibodies. A decrease of the skin score and an improvement of disability indexes matched with the in vitro results. A single course of rituximab reduced @entity4 fibroblast activation in vitro and the serum levels of anti- @entity5 stimulatory autoantibodies. CONCLUSIONS: These data provide further evidence of B-cell involvement in the pathogenesis of @entity4 . Targeting B cells may be a promising treatment for @entity4 @entity0 , and controlled clinical trials are warranted.

title: Reduced type I collagen gene expression by skin fibroblasts of XXXX with @entity2 after one treatment course with rituximab.

answer: @entity0


abstract: The cardiac rate and rhythm were studied by 24-hour ambulatory electrocardiographic recording in 44 @entity0 before, during, and after being discharged from hospital following an @entity3 . The first recordings were started 48 hours before discharge, the second on the morning of the day of discharge, and the third 48 hours after discharge (at home). While in hospital and after returning home the heart rate fell during sleep but there was no diurnal variation in the frequency of @entity5 . Daytime heart rate and both the frequency and grade (severity) of @entity4 were significantly raised 48 hours after discharge. The frequency of @entity5 was also increased in the 48 hours post-discharge recording. Rises in heart rate and frequency and severity of @entity5 were observed on the morning of the day of discharge, increasing up to the time of leaving hospital, but during the journey home they all diminished. No relation was found between ventricular arrythmias during early convalescence and (i) @entity4 during the acute phase of @entity3 (including @entity6 ); (ii) peak @entity2 aminotransferase; (iii) the level of @entity1 ; or (iv) the personality type. Six @entity0 taking beta-blocking drugs behaved similarly. Five @entity0 taking anxiolytic drugs has significantly raised frequency of @entity5 during each 24-hour electrocardiogram. In spite of the above findings, at the time of leaving hospital after @entity3 there does not appear to be a serious risk from the development of major @entity4 .

title: XXXX 48 hours before, during, and 48 hours after discharge from hospital following @entity3 .

answer: @entity4


abstract: The cardiac rate and rhythm were studied by 24-hour ambulatory electrocardiographic recording in 44 @entity0 before, during, and after being discharged from hospital following an @entity3 . The first recordings were started 48 hours before discharge, the second on the morning of the day of discharge, and the third 48 hours after discharge (at home). While in hospital and after returning home the heart rate fell during sleep but there was no diurnal variation in the frequency of @entity5 . Daytime heart rate and both the frequency and grade (severity) of @entity4 were significantly raised 48 hours after discharge. The frequency of @entity5 was also increased in the 48 hours post-discharge recording. Rises in heart rate and frequency and severity of @entity5 were observed on the morning of the day of discharge, increasing up to the time of leaving hospital, but during the journey home they all diminished. No relation was found between ventricular arrythmias during early convalescence and (i) @entity4 during the acute phase of @entity3 (including @entity6 ); (ii) peak @entity2 aminotransferase; (iii) the level of @entity1 ; or (iv) the personality type. Six @entity0 taking beta-blocking drugs behaved similarly. Five @entity0 taking anxiolytic drugs has significantly raised frequency of @entity5 during each 24-hour electrocardiogram. In spite of the above findings, at the time of leaving hospital after @entity3 there does not appear to be a serious risk from the development of major @entity4 .

title: @entity4 48 hours before, during, and 48 hours after discharge from hospital following XXXX .

answer: @entity3


abstract: BACKGROUND: Despite both @entity4 and @entity2 confer substantial burden of disease, natural course of @entity4 and the relationship with metabolic adversities have not examined. We explore associations between trajectories of @entity4 and @entity2 , lifestyle factors and comorbidities. METHODS: This retrospective cohort study included 13,745 subjects (8113 @entity0 and 5632 @entity0 ) 40-59 years of age who underwent health examinations at the Seoul National University Hospital Healthcare System, Gangnam Center, in Korea. The median follow-up duration was 4.0 years. We estimated the mean trajectories of the Beck @entity4 Inventory scores using latent-class growth-curve analysis. RESULTS: We identified four distinctive trajectories of @entity4 in both sex. The probabilities of group membership were 35.1% (n=2374) in minimal, 47.4% (n=4545) in persistent-mild, 14.4% (n=987) in persistent-moderate, and 3.0% (n=207) in persistent-severe in @entity0 , and 36.3% (n=1883), 50.0% (n=3069), 12.3% (n=601) and 1.5% (n=79) in @entity0 . We found significant increasing trend in the prevalence of @entity2 in more severe depressive trajectory. The adjusted odds ratios of persistent-severe were significantly increased for the following variables: low HDL, @entity5 , and @entity2 ( @entity2 ) in @entity0 and @entity5 , @entity2 in @entity0 , and smoking, @entity3 consumption and lack of exercise in both genders. LIMITATIONS: Medical and @entity1 histories were obtained using a self-reported questionnaire rather than formal diagnostic assessments. CONCLUSIONS: The higher level of @entity4 trajectory was associated with @entity2 , especially @entity6 , and several modifiable lifestyle factors. Our findings provide important implications for developing health policy and guidelines for reducing depressive symptom burden.

title: XXXX trajectories and the association with metabolic adversities among the middle-aged adults.

answer: @entity4


abstract: Myocardial function and peripheral hemodynamic alterations were measured through the late stages of @entity0 endotoxin shock. 60 min postendotoxin paired animals were given infusions of either 5 ml/kg per hr of 5% @entity1 or @entity1 plus @entity6 (0.25 mug/kg per min). Comparable blood lactic and @entity5 levels were determined, the excess @entity4 calculated, and pH values were obtained. During the initial stages the classic pattern of hemodynamic alterations was observed; an excess of @entity4 appeared and the pH decreased. Outstanding was evidence of markedly reduced myocardial function in the late stages of shock with progressive rise in left ventricular end diastolic pressure (LVEDP), low cardiac index, rise of central venous pressure, increased central blood volume, @entity2 , and declining arterial pressure. Analyses of left ventricular function curves also indicated @entity3 . Infusion of @entity1 alone failed to decrease mortality rate (10 of 18 dying), whereas the rate was significantly decreased with @entity6 (2 of 18). @entity1 infusion did not benefit myocardial function. @entity6 resulted in a marked improvement in myocardial action with a significant increase in heart work associated with, yet very minor, increments of LVEDP. In addition, @entity2 subsided, peripheral resistance decreased, and the blood pressure stabilized. The prognostic value of excess @entity4 was doubtful but a progressive fall in later stages was associated with survival.

title: Hemodynamic effects of XXXX in @entity0 endotoxin shock.

answer: @entity6


abstract: Myocardial function and peripheral hemodynamic alterations were measured through the late stages of @entity0 endotoxin shock. 60 min postendotoxin paired animals were given infusions of either 5 ml/kg per hr of 5% @entity1 or @entity1 plus @entity6 (0.25 mug/kg per min). Comparable blood lactic and @entity5 levels were determined, the excess @entity4 calculated, and pH values were obtained. During the initial stages the classic pattern of hemodynamic alterations was observed; an excess of @entity4 appeared and the pH decreased. Outstanding was evidence of markedly reduced myocardial function in the late stages of shock with progressive rise in left ventricular end diastolic pressure (LVEDP), low cardiac index, rise of central venous pressure, increased central blood volume, @entity2 , and declining arterial pressure. Analyses of left ventricular function curves also indicated @entity3 . Infusion of @entity1 alone failed to decrease mortality rate (10 of 18 dying), whereas the rate was significantly decreased with @entity6 (2 of 18). @entity1 infusion did not benefit myocardial function. @entity6 resulted in a marked improvement in myocardial action with a significant increase in heart work associated with, yet very minor, increments of LVEDP. In addition, @entity2 subsided, peripheral resistance decreased, and the blood pressure stabilized. The prognostic value of excess @entity4 was doubtful but a progressive fall in later stages was associated with survival.

title: Hemodynamic effects of @entity6 in XXXX endotoxin shock.

answer: @entity0


abstract: OBJECTIVE: To identify @entity5 ( @entity5 )-associated chromatin sequences and target genes in primary @entity0 abdominal subcutaneous fat. METHODS: @entity5 chromatin immunoprecipitation (ChIP)-sequencing (seq) methodology in subcutaneous @entity0 adipocytes treated ex vivo with @entity3 ( @entity6 ) was optimized to identify genome-wide @entity6 -dependent @entity5 -binding regions (GBRs). Gene expression analyses were performed in parallel        @entity6 treatment. RESULTS: Fat was obtained from four female surgical @entity0 without @entity1 with a median age of 50.5 years. ChIP-seq analysis revealed 219 @entity6 -associated GBRs. Of these, 136 GBRs were located within 100 kb of the transcriptional start site and associated with 123 genes. Combining these data with @entity6 -induced gene expression, 70 of the 123 putative direct target genes were significantly up- or downregulated following 4 hours of @entity6 treatment. Gene expression analysis demonstrated that the top 10 pathways reflected regulation of cellular metabolism and @entity2 . @entity7 , an inhibitor of @entity4 , was identified as a potential direct @entity5 target gene. CONCLUSIONS: This is the first report of genome-wide GR ChIP-seq and gene expression analysis in @entity0 fat. The results implicate regulation of key @entity5 target genes that are involved in dampening @entity2 and promoting cellular metabolism.

title: XXXX ChIP-sequencing of subcutaneous fat reveals modulation of inflammatory pathways.

answer: @entity5


abstract: BACKGROUND: @entity5 is a devastating complication of @entity4 and @entity1 ( @entity1 ). It arises even in @entity0 with normoglycemia (glycosylated hemoglobin, @entity11  <=7  %). As @entity4 and @entity1 are approaching epidemic levels worldwide, the @entity5 associated with these diseases must be therapeutically addressed. We have recently analyzed the systemic effects of a 12-week high fat diet (HFD) on wild type @entity2 from the C57Bl/6 (B6) strain and the wild type super-healing Murphy Roths Large (MRL) @entity2 . The MRL HFD @entity2 gained significantly more weight than their control diet counterparts, but did not present any of the other usual systemic @entity1 phenotypes. METHODS: Cardiac pathology and adaptation to HFD-induced @entity4 in the MRL @entity2 compared to the HFD C57Bl/6 @entity2 were thoroughly analyzed with echocardiography, histology, qPCR, electron microscopy and immunoblots. RESULTS: The @entity4 HFD C57Bl/6 @entity2 develop @entity8 , cardiomyocyte lipid droplets, and initiate an ineffective metabolic adaptation of an overall increase in electron transport chain complexes. In contrast, the @entity4 HFD MRL hearts do not display @entity7 nor lipid droplets and their metabolism adapts quite robustly by decreasing pAMPK levels, decreasing proteins in the @entity9 metabolism pathway and increasing proteins utilized in the b-oxidation pathway. The result of these metabolic shifts is the reduction of toxic lipid deposits and reactive @entity3 species in the hearts of the @entity4 HFD fed MRL hearts. CONCLUSIONS: We have identified changes in metabolic signaling in @entity4 HFD fed MRL @entity2 that confer resistance to @entity12 . The changes include a reduction of cardiac pAMPK, @entity10 and @entity13 in the MRL HFD hearts. Overall the MRL hearts down regulate @entity6 metabolism and favor lipid metabolism. These adaptations are essential to pursue for the identification of novel therapeutic targets to combat @entity4 related @entity5 .

title: Successful metabolic adaptations leading to the prevention of high fat diet-induced XXXX cardiac remodeling.

answer: @entity2


abstract: UNASSIGNED: Endoscopic resection (ER) allows for local therapy of superficial @entity3 . Factors reported to be associated with an increased risk of lymph node @entity1 in @entity0 with @entity4 are poor differentiation, lymphovascular invasion (LVI), and @entity1 >500   . The aim of this study was to determine whether depth of invasion and @entity2 characteristics in an ER specimen can be used to gauge the risk of lymph node @entity1 in @entity0 with superficial @entity4 . @entity0 from seven US centers that had ER of an @entity4 followed by an esophagectomy were identified. The ER pathology slides were rereviewed by three experienced GI pathologists for depth of invasion, presence of LVI, and @entity2 differentiation. The findings from the ER specimen were correlated with the presence and number of lymph node @entity1 in the final esophagectomy specimen. There were 19 T1a and 23 T1b @entity2 . A median of 24 nodes were resected per @entity0 . None of the T1a @entity2 had involved lymph nodes despite the presence of LVI in 5  % and poor differentiation in 21  % of @entity0 . In contrast, 26  % of T1b @entity2 had involved nodes. None of the four @entity0 with @entity1  <=500   , no LVI, and no poor differentiation had involved nodes. However, with an increasing number of risk factors, the likelihood of involved lymph nodes increased, reaching 50  % when all three factors were present. Endoscopic therapy appears appropriate for @entity2 and may be an option for low-risk T1b @entity2 . Esophagectomy is preferred for @entity0 with @entity1 and one or more risk factors.

title: Can the Risk of Lymph Node Metastases Be Gauged in Endoscopically Resected XXXX ? A Multi-Center Study.

answer: @entity4


abstract: BACKGROUND: Increasingly the trans-radial route (TRR) is preferred over the trans-femoral route (TFR) for PCI. However, even in high volume default TRR centers a cohort of @entity0 undergo TFR PCI. We examined the demographics, procedural characteristics, and outcomes of @entity0 undergoing PCI via the TF. METHODS: The @entity0 demographics, procedural data, and outcomes of 5,379 consecutive @entity0 undergoing PCI at a default radial center between 2009 and 2012 were examined. @entity3 ( @entity3 ) was classified by ACUITY and BARC definitions. RESULTS: A total of 559 (10.4%) @entity0 underwent PCI via the TFR and 4,820 @entity0 via the TRR (89.6%). Baseline variables associated with TFR were shock, previous CABG, chronic total occlusion intervention, rotablation/laser use, female sex, and @entity1 . Sixty-five @entity0 of the TFR cohort (11.6%) experienced @entity3 with 27 (41.5%) being access site related. @entity3 was significantly more frequent than in the radial cohort. The variables independently associated with @entity3 in the TFR cohort were @entity1 , acute presentation, shock, and age. In the TFR, @entity0 with @entity3 mortality was high at 30 days (17.2% vs 2.6% for no @entity3 , P   <   0.0001) and at 1 year (37.6% vs 5.0%, P   <   0.0001). Shock and @entity3 were highly predictive of 30 day and 12 month mortality. CONCLUSION: In a default radial PCI center 10% of @entity0 undergo PCI via the femoral artery. These @entity0 have high baseline @entity3 risk and undergo complex interventions. As a result the incidence of major @entity3 , transfusion and @entity2 are high. Alternative strategies are required to optimize outcomes in this select group.

title: Femoral Access PCI in a Default Radial Center Identifies High-Risk XXXX With Poor Outcomes.

answer: @entity0


abstract: UNASSIGNED: Shortly prior to @entity0 , many species of Lepidoptera infected with nucleopolyhedrovirus climb upwards on the host plant. This results in improved dissemination of viral occlusion bodies over plant foliage and an increased probability of transmission to healthy conspecific larvae. Following applications of @entity2 for control of @entity2 exigua on greenhouse-grown sweet pepper crops, necrophagy was observed by healthy S. exigua larvae that fed on virus-killed conspecifics. We examined whether this risky behavior was induced by olfactory or phagostimulant compounds associated with infected cadavers. Laboratory choice tests and olfactometer studies, involving infected and non-infected cadavers placed on @entity1 leaf discs, revealed no evidence for greater attraction of healthy larvae to virus-killed over non-infected cadavers. Physical contact or feeding on infected cadavers resulted in a very high incidence of transmission (82-93% lethal disease). Observations on the behavior of S. exigua larvae on pepper plants revealed that infected insects died on the uppermost 10% of foliage and closer to the plant stem than healthy conspecifics of the same stage, which we considered clear evidence of baculovirus-induced climbing behavior. Healthy larvae that subsequently foraged on the plant were more frequently observed closer to the infected than the non-infected cadaver. Healthy larvae also encountered and fed on infected cadavers significantly more frequently and more rapidly than larvae that fed on non-infected cadavers. Intraspecific necrophagy on infected cadavers invariably resulted in virus transmission and @entity0 of the necrophagous insect. We conclude that, in addition to improving the dissemination of virus particles over plant foliage, baculovirus-induced climbing behavior increases the incidence of intraspecific necrophagy in S. exigua, which is the most efficient mechanism of transmission of this lethal pathogen.

title: Baculovirus-Induced Climbing Behavior Favors Intraspecific Necrophagy and Efficient Disease Transmission in XXXX exigua.

answer: @entity2


abstract: UNASSIGNED: Characteristics associated with life expectancy in @entity2 ( @entity2 ) are still far from known. Here we aimed at examining the ability of baseline/longitudinal clinical variables to predict time to @entity3 . One-hundred fifty @entity2 outpatients underwent diagnostic, @entity1 , and functional assessment at baseline (when @entity4 was also investigated) and at each subsequent annual visit. A random effects joint modeling approach was used to simultaneously model the baseline and longitudinal trajectory of each factor and predict the time to @entity3 , adjusting for demographic covariates. An ancillary analysis of @entity4 status as a predictor was also conducted. Kaplan-Meier survival curves were constructed to elucidate the relationship between each factor and the estimated probability of @entity3 over time. Shorter survival was associated with male gender, higher education, older age, lower cognition, and worse functioning in daily life, but not @entity4 status. Longitudinal trajectories increased predictive power over using just baseline levels highlighting apathy, and secondarily aberrant motor behaviors and @entity0 , as a highly reliable predictor for mortality. Apathy was the strongest @entity1 predictor of time to @entity3 , which supports its role in the pathogenesis of the disorder. An increased knowledge of factors modulating survival in @entity2 is a strategic prerequisite to plan therapeutic interventions.

title: Longitudinal Neuropsychiatric Predictors of  Death in XXXX .

answer: @entity2


abstract: UNASSIGNED: It has long been suggested that face recognition relies on specialized mechanisms that are not involved in visual recognition of other object categories, including those that require expert, fine-grained discrimination at the exemplar level such as written words. But according to the recently proposed many-to-many theory of object recognition (MTMT), visual recognition of faces and words are carried out by common mechanisms [Behrmann, M., _ Plaut, D. C. ( 2013 ). Distributed circuits, not circumscribed centers, mediate visual recognition. Trends in Cognitive Sciences, 17, 210-219]. MTMT acknowledges that face and word recognition are lateralized, but posits that the mechanisms that predominantly carry out face recognition still contribute to word recognition and vice versa. MTMT makes a key prediction, namely that acquired prosopagnosics should exhibit some measure of @entity1 . We tested this prediction by assessing written word recognition in five acquired prosopagnosic @entity0 . Four @entity0 had lesions limited to the right hemisphere while one had bilateral lesions with more pronounced lesions in the right hemisphere. The @entity0 completed a total of seven word recognition tasks: two lexical decision tasks and five reading aloud tasks totalling more than 1200 trials. The performances of the four older @entity0 (3 female, age range 50-64 years) were compared to those of 12 older controls (8 female, age range 56-66 years), while the performances of the younger prosopagnosic (male, 31 years) were compared to those of 14 younger controls (9 female, age range 20-33 years). We analysed all results at the single- @entity0 level using Crawford's t-test. Across seven tasks, four prosopagnosics performed as quickly and accurately as controls. Our results demonstrate that acquired prosopagnosia can exist without @entity1 . These findings are inconsistent with a key prediction of MTMT. They instead support the hypothesis that face recognition is carried out by specialized mechanisms that do not contribute to recognition of written words.

title: Acquired prosopagnosia without XXXX .

answer: @entity1


abstract: BACKGROUND/AIM: In addition to locoregional recurrence distant @entity1 can limit the survival of @entity0 with @entity2 . The aim of the study was to analyze survival after distant metastasis of @entity2 . @entity0 AND METHODS: @entity0 with @entity2 and M0 status at initial diagnosis, who were treated with curative intent but developed distant @entity1 without synchronous locoregional recurrence were analyzed. Predictors for the duration of survival were evaluated using Cox regression analysis. RESULTS: A total of 46 @entity0 developed distant @entity1 which were detected after a mean time of 16 months, most were lung (59%) and bone @entity1 (24%). The most common therapy for distant metastasis was palliative chemotherapy; due to poor general condition, 21% of @entity0 were treated with best supportive care. The mean survival was 7.5 months, the overall survival at 1 and 2 years after diagnosis of distant metastasis were 40.4% and 26.2%, respectively. Regression analysis showed no significant predictors for prolonged survival, however, the three @entity0 surviving at the time of data collection were treated by surgical resection of solitary @entity1 . CONCLUSION: In cases of distant @entity1 , due to poor prognosis of the @entity0 , palliation is important and the treatment approach should be chosen taking into account the general condition of the @entity0 . In individual cases, resection of solitary @entity1 may be useful.

title: Survival After Distant Metastasis in XXXX .

answer: @entity2


abstract: UNASSIGNED: Introduction   @entity4 ( @entity5 ) has been shown to decrease hemoglobin loss and reduce the need for transfusions in primary hip and knee arthroplasty. Our study evaluated the safety and efficacy of topical @entity5 in revision TKA for @entity2 ( @entity2 ). Methods   We performed a retrospective review of @entity0 who underwent removal of hardware with antibiotic spacer placement (stage 1) and/or revision TKA (stage 2) for @entity2 at our institution between September 2007 and July 2013. During that time, 49 @entity0 underwent stage-1 procedures (20 knees with @entity5 , 29 without @entity5 ) and 47 @entity0 underwent stage-2 revisions (28 with @entity5 , 19 without @entity5 ). We evaluated hemoglobin loss, need for transfusion, reinfection rate, length of stay (LOS), complications, and mortality with and without the use of @entity5 in these @entity0 . All data sets were analyzed with a two-sample t-test. Results   Average follow-up was 3.15 years (range, 1-7 years). @entity5 use led to a significantly lower percentage drop in the postoperative lowest hemoglobin compared with the preoperative hemoglobin in stage-1 surgeries (19.8 vs. 30.05%, p   =   0.0004) and stage-2 revisions (24.5 vs 32.01%, p   =   0.01). In both groups, @entity5 use was associated with a significant reduction in transfusion rates (stage-1, 25 vs 51.7%, p   =   0.04; stage-2, 25 vs. 52.6%, p   =   0.05). There was a nonstatistical decreased LOS in both groups in which @entity5 was used (stage 1, 5.15 vs. 6.72 days, p   =   0.055; stage 2, 5.21 vs. 6.84 days, p   =   0.09). There was no difference in the reinfection rate (4 vs. 4, p   =   0.56) or mortality rate between groups (0 vs. 2 non- @entity5 group). A single @entity8 deep vein @entity3 occurred in a stage-1 @entity0 who received @entity5 , and no @entity6 occurred. Conclusion   We show that topical @entity5 is safe and effective for use in both stages of revision TKA for @entity2 . Previous studies have shown @entity5 to aggravate a @entity7 in @entity1 ; however, topical @entity5 doesn't appear to negatively effect on the treatment of @entity2 in our @entity0 and did not increase the reinfection, complication, or mortality rate.

title: Topical XXXX Use in Knee Periprosthetic Joint Infection is Safe and Effective.

answer: @entity4


abstract: Neoadjuvant therapy is very often an adequate alternative to adjuvant therapy. This review is summarizing the recent advances made in the area of neoadjuvant therapy in @entity0 . The focus will lie on recently published clinical trials but will not further highlight surgical, imaging and radiooncological issues related to neoadjuvant therapy. RECENT FINDINGS: Within the last 1-1.5 years it has been discussed if neoadjuvant treatment can be used as faster way to get access to new therapies, based on new data in @entity2 + @entity0 suggesting a higher pCR rate when a dual anti- @entity2 therapy was used. Nevertheless this higher pCR rate does not necessarily translate always into a better survival. In TNBC @entity3 could be identified as an asset for @entity1 , especially in @entity1 with gBRCA mutations. However, mature long term data are still missing. The neoadjuvant approach is ideal to identify new biomarkers which predict response or resistance to the given treatment. Tumour infiltrating lymphocytes and @entity4 mutations are amongst the most promising markers. SUMMARY: Neoadjuvant treatment should be considered for all @entity1 with @entity2 -positive or triple negative @entity0 . Clinical trials in this setting are currently investigating new approaches.

title: Neoadjuvant treatment of XXXX --Clinical and research perspective.

answer: @entity0


abstract: BACKGROUND: Guidelines recommend extended thromboprophylaxis following colectomy for @entity1 , but not for non- @entity1 . The aim of this study was to determine absolute and relative rates of @entity2 ( @entity2 ) following colectomy by indication, admission type and time after surgery. METHODS: A cohort study of @entity0 undergoing colectomy in England was undertaken using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data (2001-2011). Crude rates and adjusted hazard ratios (HRs) were calculated for the risk of first @entity2 following colectomy using Cox regression analysis. RESULTS: Some 12   388 @entity0 were identified; 312 (2  5 per cent) developed @entity2 after surgery, giving a rate of 29  59 (95 per cent c.i. 26  48 to 33  06) per 1000 @entity0 -years in the first year after surgery. Overall rates were 2  2-fold higher (adjusted HR 2  23, 95 per cent c.i. 1  76 to 2  50) for emergency compared with elective admissions (39  44 versus 25  78 per 1000 @entity0 -years respectively). Rates of @entity2 were 2  8-fold higher in @entity0 with @entity1 versus those with non- @entity1 (adjusted HR 2  84, 2  04 to 3  94). The rate of @entity2 was highest in the first month after emergency surgery, and declined from 121  68 per 1000 @entity0 -years in the first month to 25  65 per 1000 @entity0 -years during the rest of the follow-up interval. Crude rates of @entity2 were similar for malignant and non- @entity1 (114  76 versus 120  98 per 1000 @entity0 -years respectively) during the first month after emergency surgery. CONCLUSION: @entity0 undergoing emergency colectomy for non- @entity1 have a similar risk of @entity2 as @entity0 with @entity1 in the first month after surgery.

title: Variation in the risk of XXXX following colectomy.

answer: @entity2


abstract: BACKGROUND: Total arch replacement and ascending aorta and arch replacement are the gold standard treatments for @entity2 and are possible treatment strategies for chronic @entity4 dissection, with good reported outcomes. However, because total arch replacement is extremely invasive, it can be difficult to perform in some @entity0 . We designed an endovascular total arch repair procedure with the use of in situ fenestration and commercially available devices, and we present our initial experience. METHODS: Seven @entity0 (chronic @entity4 aortic dissection, n  = 3; thoracic arch @entity1 , n  = 4) who underwent endovascular total arch repair with the use of in situ fenestration thoracic endovascular aortic repair from a zone 0 landing were retrospectively analyzed. All the procedures were performed under general anesthesia and cardiopulmonary bypass. The triple branches were manually punctured in a retrograde manner with the use of an 18-gauge/30-cm needle or a 21-gauge aspiration needle, and all the branches were reconstructed with the use of stent grafts; balloon touch-up was performed if appropriate. RESULTS: The procedure was successful in 6 of the 7 @entity0 ; the remaining 1 @entity0 additionally underwent an axillary-axillary artery bypass during the operation because the left subclavian artery was difficult to puncture. All the @entity0 had an acceptable postoperative course, with no 30-day and in-hospital deaths. None of the @entity0 had @entity3 , and all the @entity0 exhibited a reduction in @entity1 diameter or thrombosed false lumen during a mean follow-up period of 17.6 months. CONCLUSIONS: Endovascular total arch repair with the use of in situ fenestration can be performed with commercially available devices with acceptable interim results.

title: Endovascular Total Arch Repair Using In Situ Fenestration for Arch XXXX and Chronic Type A Dissection.

answer: @entity1


abstract: PURPOSE: Portal cavernoma follows a chronic occlusion of the portal vein. The long-term consequences of portal cavernoma are not well known. The objective of this study was to report the aetiology of the portal cavernoma and its natural course after excluding @entity4 causes. METHODOLOGY: A single centre retrospective study based on the data collected from the radiology department of the Clermont-Ferrand hospital was conducted from 2000 to 2011. All the @entity0 for whom an imagery found a portal cavernoma have been looked for excluding the @entity0 having a @entity4 whatever the aetiology and the @entity8 . RESULTS: Thirty-two cases (18  @entity0 and 14  @entity0 ) were selected. The mean age at diagnosis was 54.2  years and the mean follow-up period was 5.4  years. The discovery of a portal cavernoma was incidental for 8  cases. An aetiology was found for 24  cases: it was an haematological aetiology in 15  cases (10  myeloproliferative syndromes, 2  antiphospholid syndromes, 1  @entity7 major, 1  @entity9 , 1  @entity5 gene mutation), a general aetiology in 2  cases (1  @entity2 , 1  pancreatic @entity1 ), and a local inflammation in 7  cases. A dysmorphic aspect of the liver was noticed on medical imaging for 11 out of the 32  cases. A liver biopsy was performed in 4  @entity0 and was normal for all of them. Sixteen @entity0 developed oesophageal varices, 4  @entity0 developed @entity6 , 3  developed asymptomatic biliary compression by the portal cavernoma, and the @entity0 who had been followed for the longest time (15  years) developed an @entity3 . CONCLUSION: In addition to its underlying etiology, the prognosis of portal is mainly related to the occurrence of oesophageal varices that may develop during the follow-up of the @entity0 .

title: [Natural history of portal cavernoma without XXXX . A single centre retrospective study of 32  cases].

answer: @entity4


abstract: Clinical results of intraoperative radiotherapy for @entity5 were reported. One hundred and five cases of @entity5 were treated by intraoperative radiotherapy. Indications for the intraoperative radiotherapy were determined as follows: 1) The @entity3 ( @entity2 ) located at the level of gastric corpus or antrum (M, A); 2) At least, the @entity2 should be resected; 3) Neither liver @entity1 nor peritoneal dissemination was noticed; 4) Lymph node @entity1 were limited to the second group (less than N3); 5) Cases of which @entity2 -infiltration-depth reached to the serosal surface (S3) of the posterior gastric wall and infiltrated to the pancreatic capsule were included. However, infiltrations to the serosal surface of the anterior gastric wall were not subjected to the treatment, because of having peritoneal disseminations. Irradiation of 2800-4000 rad of electron beam from betatron was performed after resection of the stomach and the regional lymph node as possible. Five-year survival rate was studied on 58 cases (consisting 5 cases of stage I, 27 cases of stage II, 12 cases of stage III and 14 cases of stage IV). Comparisons were done with the cases receiving surgical operation only. RESULTS: Whatever the stage of the @entity0 was, 3-year survival rate was found to be better in the radiotherapy group than that of the control group (treated surgical resection only). Five year survival rate of the stages III and IV in the radiotherapy group was better than the control group. Unfavorable side effects were observed in 4 cases out of 105 cases. In one case, penetration of postoperative peptic ulcer into the irradiated aortic wall was found by autopsy. Two cases of @entity6 and one case of ileus due to acutely developed @entity4 were experienced. In conclusion, intraoperative radiotherapy immediately after surgical resection for the treatment of @entity5 was found to be an effective method. The most effective application of the method appears to be to cases of stage II and III without liver @entity1 and peritoneal disseminations (H0P0, M, A).

title: [Intraoperative radiotherapy of XXXX ].

answer: @entity2


abstract: OBJECTIVE: As measurements of subjective @entity3 after @entity1 ( @entity1 ) rely on self-assessment, deficits in self-awareness after @entity1 may distort subjective @entity3 reports. This study investigates awareness of subjective @entity3 after @entity1 using self- and informant reports. @entity0 : Fourteen adults with moderate to severe @entity1 and 7 healthy controls (HCs). MEASURES: Modified Fatigue Impact Scale (MFIS) and battery of cognitive and emotional tests. Informants completed an "other-report," rating their perception of @entity0 's @entity3 . Subjective @entity3 awareness was defined as discrepancy between self- and other-MFIS scores. RESULTS: Adults with @entity1 showed greater discrepancies between self- and other-MFIS scores than did HCs. Negative relations were found between @entity3 @entity2 , but there were no relationships between @entity3 awareness and cognitive performance. CONCLUSIONS: Results indicate that adults with @entity1 have poorer awareness of subjective @entity3 than HCs. Correlations between subjective @entity3 awareness and @entity2 support existing literature implicating strong emotional components in the experience of subjective @entity3 postinjury. Findings suggest cautious interpretation of subjective @entity3 , as responses may not reflect @entity3 symptoms exclusively.

title: Awareness of Subjective Fatigue After Moderate to Severe XXXX .

answer: @entity1


abstract: BACKGROUND: @entity11 (or bilharzia), a major @entity12 , affects more than 260 million @entity0 worldwide. In chronic cases of @entity8 caused by trematodes of the @entity6 genus, @entity9 develops as a host immune response to the helminth eggs, followed by potentially lethal portal @entity4 . In this study, we characterized hepatic and splenic features of a @entity1 model of @entity8 using in vivo magnetic resonance imaging (MRI) and evaluated the transverse relaxation time T2 as a non-invasive imaging biomarker for monitoring hepatic fibrogenesis. METHODOLOGY/PRINCIPAL FINDINGS: CBA/J @entity1 were imaged at 11.75 T two, six and ten weeks after percutaneous @entity5 with @entity6 . In vivo imaging studies were completed with histology at the last two time points. Anatomical MRI allowed detection of typical manifestations of the @entity10 such as significant hepato- and @entity7 , and dilation of the portal vein as early as six weeks, with further aggravation at 10 weeks after @entity5 . Liver multifocal lesions observed by MRI in infected animals at 10 weeks post @entity5 corresponded to @entity2 and intergranulomatous @entity3 with METAVIR scores up to A2F2. While most healthy hepatic tissue showed T2 values below 14 ms, these lesions were characterized by a T2 greater than 16 ms. The area fraction of increased T2 correlated (rS = 0.83) with the area fraction of Sirius Red stained collagen in histological sections. A continuous liver T2* decrease was also measured while brown pigments in macrophages were detected at histology. These findings suggest accumulation of hematin in infected livers. CONCLUSIONS/SIGNIFICANCE: Our multiparametric MRI approach confirms that this @entity1 model replicates hepatic and splenic manifestations of @entity0 @entity8 . Quantitative T2 mapping proved sensitive to assess liver fibrogenesis non-invasively and may therefore constitute an objective imaging biomarker for treatment monitoring in diseases involving @entity9 .

title: In Vivo MRI Assessment of Hepatic and Splenic Disease in a @entity1 Model of XXXX [corrected].

answer: @entity11


abstract: BACKGROUND: @entity11 (or bilharzia), a major @entity12 , affects more than 260 million @entity0 worldwide. In chronic cases of @entity8 caused by trematodes of the @entity6 genus, @entity9 develops as a host immune response to the helminth eggs, followed by potentially lethal portal @entity4 . In this study, we characterized hepatic and splenic features of a @entity1 model of @entity8 using in vivo magnetic resonance imaging (MRI) and evaluated the transverse relaxation time T2 as a non-invasive imaging biomarker for monitoring hepatic fibrogenesis. METHODOLOGY/PRINCIPAL FINDINGS: CBA/J @entity1 were imaged at 11.75 T two, six and ten weeks after percutaneous @entity5 with @entity6 . In vivo imaging studies were completed with histology at the last two time points. Anatomical MRI allowed detection of typical manifestations of the @entity10 such as significant hepato- and @entity7 , and dilation of the portal vein as early as six weeks, with further aggravation at 10 weeks after @entity5 . Liver multifocal lesions observed by MRI in infected animals at 10 weeks post @entity5 corresponded to @entity2 and intergranulomatous @entity3 with METAVIR scores up to A2F2. While most healthy hepatic tissue showed T2 values below 14 ms, these lesions were characterized by a T2 greater than 16 ms. The area fraction of increased T2 correlated (rS = 0.83) with the area fraction of Sirius Red stained collagen in histological sections. A continuous liver T2* decrease was also measured while brown pigments in macrophages were detected at histology. These findings suggest accumulation of hematin in infected livers. CONCLUSIONS/SIGNIFICANCE: Our multiparametric MRI approach confirms that this @entity1 model replicates hepatic and splenic manifestations of @entity0 @entity8 . Quantitative T2 mapping proved sensitive to assess liver fibrogenesis non-invasively and may therefore constitute an objective imaging biomarker for treatment monitoring in diseases involving @entity9 .

title: In Vivo MRI Assessment of Hepatic and Splenic Disease in a XXXX Model of @entity11 [corrected].

answer: @entity1


abstract: @entity2 ( @entity2 ) occurs in @entity0 of reproductive age. Of 20 @entity0 with @entity2 in this study, 10 were pregnant or immediately postpartum, and 7 were taking oral contraceptive @entity1 . Only three of the 20 @entity0 were not pregnant or taking exogenous hormones. All @entity2 nodules were composed mainly of spindle cells, but decidual cells were admixed with the spindle cells in some of the nodules in six of the 10 pregnant and postpartum @entity0 . Electron microscopy was applied to the nodules from six @entity0 representing the three different hormonal backgrounds. All contained smooth muscle cells. One was composed exclusively of smooth muscle cells, while four of the six contained smooth muscle cells predominantly but were admixed with myofibroblasts or altered smooth muscle cells and fibroblasts. Decidual cells were conspicuous in the nodules examined ultrastructurally from a pregnant @entity0 . Despite incomplete excisions, none of the 14 @entity0 with follow-up had progressive disease. Complete or partial regression of @entity2 was verified by "second-look" laparotomy in four @entity0 , but a repeat cesarian section in a fifth @entity0 revealed persistence (or recurrence) of @entity2 1.5 years after the initial diagnosis. @entity2 probably results from an unusual predisposition, or selective sensitivity, of subperitoneal mesenchymal stem cells in some @entity0 to undergo metaplasia and differentiation to smooth muscle, fibroblasts, myofibroblasts, and decidual cells. In the majority of @entity0 , hormonal stimulation is an initiator or promoter of the process.

title: XXXX (leiomyomatosis peritonealis disseminata): a clinicopathologic study of 20 cases with ultrastructural observations.

answer: @entity2


abstract: INTRODUCTION: Despite increasingly better diagnostic and therapeutic methods @entity4 , invariably pose a direct threat to the lives of @entity0 and a challenge for otolaryngologists. AIM: The aim of the study was to analyze @entity0 with @entity4 treated at the Department of Otolaryngology and Otolaryngological Oncology of Pozna   University of Medical Sciences in the years 2000-2013. MATERIAL AND METHODS: Analysis covered the period from January 2000 to December 2013. Twenty-one @entity0 with @entity4 were treated at the Department of Otolaryngology in Poznan during that time. RESULTS: Material mainly included young @entity0 . @entity2 were the most common complications. Intracranial complications of @entity3 rarely occurred in isolation, often coexisting with other intracranial pathologies. A significant increase in the incidence was recorded in 2013. Treatment involved concurrently alleviating @entity1 in the sinuses through implementation of broad-spectrum antibiotics for several weeks and decompressing the organized intracerebral abscesses, @entity6 , epidural and/or subdural abscesses under control of neuronavigation. There were no @entity0 deaths recorded in the analyzed period. CONCLUSIONS: The risk of developing @entity4 is low but invariably present and should be included in the differential diagnosis. Since the incidence of @entity4 may increase in the course of prevailing @entity5 , it should raise diagnostic vigilance.

title: Intracranial complications from XXXX .

answer: @entity3


abstract: BACKGROUND: The disease spectrum of crescentic @entity2 ( @entity2 ) has been described in only a few previous studies, and detailed epidemiologic data from China are unavailable to date. STUDY DESIGN: Case series. SETTING _ @entity0 : 528 @entity0 with biopsy-proven crescentic @entity2 in 2003 to 2013 from a single center. PREDICTOR: Crescentic @entity2 was classified into 3 types according to immunofluorescence findings: type I was defined as linear deposition of immunoglobulins along the glomerular basement membrane; type II, as glomerular deposition of immune complex; and type III, as @entity5 . OUTCOMES: Demographic, clinical, and serologic characteristics. RESULTS: Of 528 cases identified, 208 (39.4%) were @entity0 , with a mean age of 37.6  16.4 (SD) years at kidney biopsy. 61 (11.6%) @entity0 had type I crescentic @entity2 , 331 (62.7%) had type II ( @entity6 , 34.3%; immunoglobulin A [IgA] @entity1 , 17.4%), and 136 (25.8%) had type III. Proportions of @entity0 with @entity4 ( @entity4 ), acute @entity1 without @entity4 , and @entity3 were 86.9%, 0%, and 13.1% for type I; 42.0%, 19.6%, and 38.4% for type II; and 84.6%, 2.9%, and 12.5% for type III crescentic @entity2 , respectively. Serum antineutrophil cytoplasmic antibodies were detected in 11 (18.0%) @entity0 with type I, 15 (4.5%) with type II, and 117 (86.0%) with type III. Anti-glomerular basement membrane antibodies were found in 60 (98.4%) @entity0 with type I, 3 (0.9%) with type II, and 5 (3.7%) with type III. 5-year cumulative renal survival rates for @entity0 with types I, II, and III were 17.6%, 70.1%, and 44.3%, respectively. LIMITATIONS: Retrospective study, single-center experience. CONCLUSIONS: @entity6 may be the most common type of crescentic @entity2 in China, followed by pauci-immune crescentic @entity2 and @entity1 . Almost half the @entity0 presented with @entity4 , whereas 28.8% of cases showed @entity3 . Clinical manifestations and outcomes varied according to crescentic @entity2 type. The distinction between subtypes based on immunofluorescence and serologic findings has important implications for therapy and outcome.

title: Etiology and Outcome of XXXX From a Single Center in China: A 10-Year Review.

answer: @entity2