abstract: PURPOSE: Transsphenoidal surgery is the treatment of choice for most @entity4 ( @entity4 ), except @entity5 . Difficulties achieving radical resection with this method are encountered in @entity0 with PAs invading the cavernous sinus (CS), due to the inability of the standard transsphenoidal approach to expose all @entity1 adequately. This study analyzed methods to resect PAs invading the CS and factors influencing the degree of @entity1 resection and occurrence of complications. METHODS: Outcomes were retrospectively analyzed in 52 @entity0 with @entity4 invading the CS who underwent surgery via the extended transsphenoidal approach utilizing multiple techniques, including microscopy, endoscopy, neuronavigation, and intraoperative Doppler ultrasonography. RESULTS: Gross-total resection (GTR) was achieved in 33 @entity0 (63.5  %). GTR rate was significantly higher in @entity0 with Knosp Grade 3 than Knosp Grade 4 (92.3 vs. 53.8  %) and in @entity0 undergoing initial surgery than reoperation (77.1 vs. 35.3  %). One @entity0 (2.9  %) undergoing initial surgery experienced transient @entity2 , without other @entity3 . @entity3 were significantly higher after reoperation. Firm @entity1 consistency was significantly more frequent in @entity0 undergoing reoperation than initial surgery (52.9 vs. 8.6  %). CONCLUSION: Extended transsphenoidal surgery incorporating multiple complementary techniques was highly effective for PAs invading the CS. @entity3 rates were relatively low, especially for @entity0 undergoing initial surgery and those with Knosp Grade 3 @entity1 . Total resection of PAs invading the CS remains challenging, especially in @entity0 undergoing reoperation or having firm @entity1 .

title: Extended transsphenoidal approach for XXXX invading the cavernous sinus using multiple complementary techniques.

answer: @entity4


abstract: UNASSIGNED: @entity2 ( @entity2 ) decreases with age and increased @entity2 is independently associated with adverse cardiovascular outcomes. The association of severe @entity1 ( @entity1 ) with @entity2 in different aortic regions has not been evaluated. Elderly subjects with severe @entity1 and a cohort of @entity0 without @entity1 of similar age were studied. Proximal aortic cross-sectional-area changes during the cardiac cycle were determined using retrospective-ECG-gating on 128-detector row computed-tomography. Using oscillometric-brachial-blood-pressure measurements, the @entity2 at the @entity3 ( @entity3 ), proximal-descending-aorta (PDA) and distal-descending-aorta (DDA) was determined. Linear mixed effects modelling was used to determine the association of age and @entity1 on regional @entity2 . 102 @entity0 were evaluated: 36 @entity1 @entity0 (70-85  years), 24 @entity1 @entity0 (>85  years) and 42 @entity0 without @entity1 (9 @entity0 <50  years, 20 @entity0 between 51-70  years and 13 @entity0 70-85  years). When comparing @entity0 70-85  years, @entity3 distensibility was significantly lower in those with @entity1 compared to those without @entity1 (0.9      0.9 vs. 1.4      1.1, P  =  0.03) while there was no difference in the PDA (1.0      1.1 vs. 1.0      1.2, P  =  0.26) and DDA (1.1      1.2 vs. 1.2      0.8, P  =  0.97). In @entity0 without @entity1 , @entity2 decreased with age in all aortic regions (P  <  0.001). The @entity3 in @entity0 <50  years were the most distensible compared to other aortic regions. There is regional variation in aortic distensibility with aging. @entity0 with @entity1 demonstrated regional differences in aortic distensibility with lower distensibility demonstrated in the proximal ascending aorta compared to an age-matched cohort.

title: Regional aortic distensibility and its relationship with age and XXXX : a computed tomography study.

answer: @entity1


abstract: Important cellular characteristics, including selective adhesion, growth rate, motility, and differentiation, are controlled, in part, by signals received at the cell surface. The molecular mechanisms for the cell surface control of these cell behaviors are largely unknown. In order to probe the role of specific extracellular molecules in controlling cell function, we report the development of synthetic surfaces which generally support the long-term growth of cells yet can be readily derivatized with a wide variety of molecules of biological interest. @entity1 gels containing a gradient of active @entity6 groups were prepared and then the @entity7 were displaced with ligands to generate a gradient of @entity3 , @entity4 , or @entity2 groups. When untransformed @entity0 fibroblasts (BALB/3T3) were seeded on the various surfaces, they attached and grew only on those derivatized with @entity5 or @entity2 groups within narrow concentration ranges. Cell growth rate, density, and morphology on @entity1 gels containing the optimal concentration of @entity3 groups (approximately 30 mumol/ml) were comparable to those on tissue culture plastic, whereas growth on @entity2 group-derivatized gels was less extensive. In contrast, short-term (90-min) adhesion to @entity2 group-derivatized gels was greater than that to @entity3 -derivatized gels. Both short-term adhesion and long-term growth required serum. Growth-supportive @entity1 gels were readily derivatized with molecules of biological interest. The techniques reported here are applicable to other types of cell in culture since the nature and concentration of substratum functional groups can be easily varied and tested for support of long-term cell growth.

title: Cell attachment and long-term growth on derivatizable XXXX surfaces.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: Increased level of very low-density lipoprotein (VLDL) is a key feature of the @entity1 and is associated with @entity0 . @entity2 -   agonists play a protective role in lipid metabolism and vascular function. In this study, we aimed to investigate the role of @entity2 -   in the uptake of VLDL in endothelial cells and its underlying mechanism(s). EXPERIMENTAL APPROACH: Uptake of VLDL in HUVECs was assessed by Dil-fluorescent labelling of VLDL. Levels of @entity4 mRNA and @entity3 ) were detected by quantitative PCR. The target genes of @entity3 were predicted using bioinformatics analysis. 3'-Untranslated region (3'-UTR) luciferase reporter and Argonaute 1 pull-down assays were used to validate the target of @entity3 . KEY RESULTS: @entity2 -   agonist @entity5 decreased uptake of VLDL and expression of @entity4 at mRNA and protein levels. @entity5 inhibited the luciferase reporter activity of the 3'-UTR of @entity4 . @entity4 was a direct target of @entity3 . @entity3 was significantly increased by @entity5 in HUVECs. Transfection of a @entity3 mimic decreased the mRNA and protein levels of @entity4 and uptake of VLDL. Furthermore, a @entity3 inhibitor abolished the inhibitory effect of @entity2 -   on @entity4 expression and VLDL uptake. CONCLUSIONS AND IMPLICATIONS: In endothelial cells, activation of @entity2 -   decreased @entity4 expression and VLDL uptake via the induction of @entity3 . These results provided a novel mechanism for the vascular protective effect of @entity2 -   agonists.

title: Activation of XXXX -   induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cells.

answer: @entity2


abstract: BACKGROUND CONTEXT: The timing of physical therapy (PT) services and its association with later function and @entity1 are not clear, especially in older adults. PURPOSE: The purpose of this study was to compare clinical outcomes of @entity0 receiving early or later PT services with those not receiving PT among older adults presenting to primary care for a new visit for back @entity1 . STUDY DESIGN/SETTING: Prospective cohort study using the Back Pain Outcomes Using Longitudinal Data registry. @entity0 SAMPLE: A total of 3,705 adults 65 years and older with a new visit for back @entity1 were included. OUTCOME MEASURES: The outcome measures were Roland-Morris Disability Questionnaire (RMDQ), Pain Numerical Rating Scales, and EuroQol-5D. METHODS: We studied two phases of PT utilization: early (0-28 days) and later (3-6 months). At baseline, we selected the @entity0 with complete 12 months of @entity0 -reported outcomes and electronic medical record data. Early PT was defined as initiating PT less than or equal to 28 days from the index visit for back @entity1 . The no early PT group consisted of @entity0 with no PT, no injections, no surgery, and no chiropractic within 28 days. We restricted the later phase analysis to @entity0 with @entity1 greater than 2 of 10 and an RMDQ score greater than 4 to create a subsample of @entity0 with continuing clinically important back @entity1 . We defined later PT as initiating PT between 3 and 6 months after the index visit. The no later PT group consisted of @entity0 without any PT during this time. We used propensity score matching followed by multiple linear regression to estimate the mean difference in outcome. Sensitivity analysis examined clinically important change and dose of PT use among the early PT group. RESULTS: The early PT group had better functional status with an adjusted mean RMDQ of 1.1 points less than the no early PT group (95% confidence interval: -2.2, -0.1) and @entity2 of -0.5 (-0.9, -0.1) at 12 months. There was no difference between early PT groups at 3 and 6 months. The odds of a 30% improvement in function or @entity1 were not different between these matched groups at 12 months, but the early PT group had increased odds of a 50% improvement in function at 12 months (odds ratio: 1.58, 95% confidence interval: 1.04, 2.40). There was no difference between later groups at 12 months. Greater dose of PT use within the early PT group was associated with better functional status (p= .01). CONCLUSIONS: We found that among older adults presenting to their primary care providers for a new @entity2 , early referral to PT resulted in no or minimal differences in @entity1 , function, or health-related quality at 3, 6, or 12 months compared with a matched group that did not receive early PT. Secondary analysis show that @entity0 initiating early PT may be somewhat more likely to experience 50% improvement in function at 12 months.

title: Clinical outcomes of early and later physical therapist services for older adults with back XXXX .

answer: @entity1


abstract: BACKGROUND: Future transportation policy is likely to reduce emissions in the cities and urban regions by strengthening active travel. Increased walking and cycling are known to have positive effects on health outcomes. This work estimates effects of increased active travel on @entity2 2 @entity1 in Germany, where 64% of the population live in urban regions. METHODS: Based on the effect size of an increased active travel scenario reported from a recent meta-analysis, we project the change in the life time risk, the proportion of prevented cases and the change in @entity1 free life time in a German birth cohort (born 1985) compared to business as usual. RESULTS: The absolute risk reduction of developing @entity2 2 @entity1 before the age of 80 is 6.4% [95% confidence interval: 3.7-9.7%] for @entity0 and 4.7% [2.2-7.7%] for @entity0 , respectively. Compared to business as usual, the increased active travel scenario prevents 14.0% [8.1-21.2%] of the future cases of @entity1 in @entity0 and 15.8% [9.3-23.1%] in @entity0 . @entity1 free survival increases by 1.7 [1.0-2.7] years in @entity0 and 1.4 [0.6-2.3] in @entity0 . CONCLUSIONS: Our projection predicts a substantial impact of increased active travel on the future burden of @entity2 2 @entity1 . The most striking effect may be seen in the number of prevented cases. In all urban regions with an increased active travel transport policy, about one out of seven male and one out of six female cases can be prevented.

title: Projected effect of increased active travel in german urban regions on the risk of XXXX 2 @entity1 .

answer: @entity2


abstract: BACKGROUND: Future transportation policy is likely to reduce emissions in the cities and urban regions by strengthening active travel. Increased walking and cycling are known to have positive effects on health outcomes. This work estimates effects of increased active travel on @entity2 2 @entity1 in Germany, where 64% of the population live in urban regions. METHODS: Based on the effect size of an increased active travel scenario reported from a recent meta-analysis, we project the change in the life time risk, the proportion of prevented cases and the change in @entity1 free life time in a German birth cohort (born 1985) compared to business as usual. RESULTS: The absolute risk reduction of developing @entity2 2 @entity1 before the age of 80 is 6.4% [95% confidence interval: 3.7-9.7%] for @entity0 and 4.7% [2.2-7.7%] for @entity0 , respectively. Compared to business as usual, the increased active travel scenario prevents 14.0% [8.1-21.2%] of the future cases of @entity1 in @entity0 and 15.8% [9.3-23.1%] in @entity0 . @entity1 free survival increases by 1.7 [1.0-2.7] years in @entity0 and 1.4 [0.6-2.3] in @entity0 . CONCLUSIONS: Our projection predicts a substantial impact of increased active travel on the future burden of @entity2 2 @entity1 . The most striking effect may be seen in the number of prevented cases. In all urban regions with an increased active travel transport policy, about one out of seven male and one out of six female cases can be prevented.

title: Projected effect of increased active travel in german urban regions on the risk of @entity2 2 XXXX .

answer: @entity1


abstract: BACKGROUND: Basic studies have shown that @entity8 ( @entity8 ) analogs exert a direct protective effect on the vascular endothelium in addition to their indirect effects on postprandial @entity4 and lipid metabolism. @entity8 analogs are also reported to inhibit @entity6 . This study examined whether the @entity8 analog exenatide inhibits @entity6 in @entity0 with @entity1 ( @entity1 ). METHODS: Seventeen @entity0 with @entity1 underwent a meal tolerance test to examine changes in postprandial vascular endothelial function and in @entity4 and lipid metabolism, both without exenatide (baseline) and after a single subcutaneous injection of 10   g exenatide. Vascular endothelial function was determined using reactive @entity5 index (RHI) measured by peripheral arterial tonometry before and 120  min after the meal loading test. The primary endpoint was the difference in changes in postprandial vascular endothelial function between the baseline and exenatide tests. RESULTS: The natural logarithmically-scaled RHI (L_RHI) was significantly lower after the baseline meal test but not in the exenatide test. The use of exenatide resulted in a significant decrease in @entity7 (TG) area under the curve and coefficient of variation (CV). The change in L_RHI correlated with changes in CV of @entity7 and HDL- @entity2 . Multivariate analysis identified changes in @entity3 CV as the only determinant of changes in L_RHI, contributing to 41% of the observed change. CONCLUSIONS: @entity9 inhibited @entity6 after the meal loading test, suggesting that exenatide has a multiphasic anti-atherogenic action involving not only @entity4 but also lipid metabolism. TRIAL REGISTRATION: ClinicalTrials.gov: UMIN000015699.

title: Effects of exenatide on XXXX in @entity1 .

answer: @entity6


abstract: BACKGROUND: Basic studies have shown that @entity8 ( @entity8 ) analogs exert a direct protective effect on the vascular endothelium in addition to their indirect effects on postprandial @entity4 and lipid metabolism. @entity8 analogs are also reported to inhibit @entity6 . This study examined whether the @entity8 analog exenatide inhibits @entity6 in @entity0 with @entity1 ( @entity1 ). METHODS: Seventeen @entity0 with @entity1 underwent a meal tolerance test to examine changes in postprandial vascular endothelial function and in @entity4 and lipid metabolism, both without exenatide (baseline) and after a single subcutaneous injection of 10   g exenatide. Vascular endothelial function was determined using reactive @entity5 index (RHI) measured by peripheral arterial tonometry before and 120  min after the meal loading test. The primary endpoint was the difference in changes in postprandial vascular endothelial function between the baseline and exenatide tests. RESULTS: The natural logarithmically-scaled RHI (L_RHI) was significantly lower after the baseline meal test but not in the exenatide test. The use of exenatide resulted in a significant decrease in @entity7 (TG) area under the curve and coefficient of variation (CV). The change in L_RHI correlated with changes in CV of @entity7 and HDL- @entity2 . Multivariate analysis identified changes in @entity3 CV as the only determinant of changes in L_RHI, contributing to 41% of the observed change. CONCLUSIONS: @entity9 inhibited @entity6 after the meal loading test, suggesting that exenatide has a multiphasic anti-atherogenic action involving not only @entity4 but also lipid metabolism. TRIAL REGISTRATION: ClinicalTrials.gov: UMIN000015699.

title: Effects of exenatide on @entity6 in XXXX .

answer: @entity1


abstract: Primary hepatic marginal zone B-cell @entity1 ( @entity1 ) is extremely rare. We present a case in which a lesion was diagnosed as 2 @entity0 ( @entity1 and @entity2 ) using contrast-enhanced ultrasonography (US) with sonazoid. There has been no previous case of contiguous hepatic @entity1 and @entity2 . The present case was a female with no medical history. We detected a snowman-like appearance, which was a @entity0 of 15 mm in diameter with hypo- and hyper-echogenicities in the lateral and medial parts, respectively, in the Couinaud's segment (S6) of the liver on US. The @entity0 appeared as a single lesion with a low-density area in the unenhanced phase and prolonged enhancement in the equilibrium phases on dynamic CT. On MRI, the whole lesion showed a low-intensity signal on T1-weighted imaging, but isointensity in the lateral part and high intensity in the medial part were seen on T2-weighted imaging. On contrast-enhanced US, the lateral hypoechoic region was homogenously hyperenhanced in the early vascular phase, and the contrast medium was washed out after about 30 s; in contrast, the medial hyperechoic region was gradually stained from the margin toward the central region. The @entity0 showed a defect in both hypo- and hyperechoic regions in the postvascular phase. @entity2 was suspected for the medial part based on the typical image findings, but the lateral part was not given a diagnosis. Thus, surgical resection was performed. The medial part was a @entity2 , and the lateral part was a @entity1 by histopathological findings.

title: A case of contiguous primary hepatic marginal zone B-cell lymphoma and XXXX ultimately diagnosed using contrast-enhanced ultrasonography.

answer: @entity2


abstract: We evaluated the antithrombotic efficacy of the low molecular weight heparin (LMWH) fraction @entity3 in nine consecutive @entity0 with @entity2 documented by pulmonary angioscan and angiography. Therapy with @entity3 was initiated by an i.v. bolus of 0.5 mg/kg, followed by a continuous intravenous infusion during the first 10 days; the drug was then given subcutaneously twice daily during the following 15 days. The dosage of @entity3 was adjusted by daily measurements of anti-Xa and anti-IIa activities using amidolytic methods. For a dosage ranging from 1.4 to 4.1 mg/kg per day during the i.v. period and from 0.7 to 3.5 mg/kg per day during the s.c. period, the anti-Xa activity ranged from 4 to 8.7 PK U/ml and from 4.5 to 7.2 PK U/ml respectively. Clinical improvement was observed in all the @entity0 and was consistent with progressive reperfusion evaluated by successive angioscans. No recurrence of @entity2 occurred. No deleterious hemorrhagic side-effects were observed, even in two @entity0 at high risk of @entity1 . In this pilot study, the LMWH fraction @entity3 proved to be an effective anticoagulant therapy during the first three weeks after @entity2 in @entity0 .

title: Treatment of XXXX by a low molecular weight heparin fraction. A preliminary study.

answer: @entity2


abstract: BACKGROUND _ AIMS: The liver is frequently challenged by toxins and reactive @entity3 species. Therefore, hepatocytes require cytoprotective strategies to cope with these insults. Since the transcription factors @entity10 and NF-kB regulate the cellular antioxidant defense system and important survival pathways, we determined their individual and overlapping functions in the liver. METHODS: We generated @entity2 lacking @entity10 and the NF-kB @entity8 / @entity8 subunit in hepatocytes and we analyzed their liver by using histopathology, immunohistochemistry, quantitative RT-PCR, Western blot and Oxyblot analysis. @entity0 @entity9 ( @entity9 ) were analyzed by immunohistochemistry. RESULTS: Loss of either @entity10 or NF-kB/ @entity8 had only a minor effect on liver homeostasis, but the double knockout @entity2 spontaneously developed @entity7 and @entity6 . Upon aging, more than one-third of the female double mutant @entity2 developed @entity1 , which histologically resemble @entity0 @entity9 , a @entity1 that predominantly occurs in @entity0 . The @entity2 @entity1 also recapitulated the immunohistochemical marker profile characteristic for @entity0 @entity9 . Moreover, pNRF2 and NF-kB @entity8 / @entity8 was not detectable in the nuclei of @entity9 @entity1 cells. The @entity2 phenotype was not due to a synergistic effect of both transcription factors on cytoprotective @entity10 target genes. Rather, loss of @entity10 or NF-kB/ @entity8 altered the expression of different genes, and the combination of these alterations likely affects liver homeostasis in the double mutant @entity2 . CONCLUSIONS: Our results provide genetic evidence for a functional cross-talk of @entity10 and NF-kB/ @entity8 in hepatocytes, which protects the liver from @entity5 , @entity4 and @entity6 . Furthermore, the double mutant @entity2 represent a valuable animal model for @entity9 .

title: NF-kB/ @entity8 and @entity10 cooperate to maintain hepatocyte integrity and to prevent development of XXXX .

answer: @entity9


abstract: BACKGROUND _ AIMS: The liver is frequently challenged by toxins and reactive @entity3 species. Therefore, hepatocytes require cytoprotective strategies to cope with these insults. Since the transcription factors @entity10 and NF-kB regulate the cellular antioxidant defense system and important survival pathways, we determined their individual and overlapping functions in the liver. METHODS: We generated @entity2 lacking @entity10 and the NF-kB @entity8 / @entity8 subunit in hepatocytes and we analyzed their liver by using histopathology, immunohistochemistry, quantitative RT-PCR, Western blot and Oxyblot analysis. @entity0 @entity9 ( @entity9 ) were analyzed by immunohistochemistry. RESULTS: Loss of either @entity10 or NF-kB/ @entity8 had only a minor effect on liver homeostasis, but the double knockout @entity2 spontaneously developed @entity7 and @entity6 . Upon aging, more than one-third of the female double mutant @entity2 developed @entity1 , which histologically resemble @entity0 @entity9 , a @entity1 that predominantly occurs in @entity0 . The @entity2 @entity1 also recapitulated the immunohistochemical marker profile characteristic for @entity0 @entity9 . Moreover, pNRF2 and NF-kB @entity8 / @entity8 was not detectable in the nuclei of @entity9 @entity1 cells. The @entity2 phenotype was not due to a synergistic effect of both transcription factors on cytoprotective @entity10 target genes. Rather, loss of @entity10 or NF-kB/ @entity8 altered the expression of different genes, and the combination of these alterations likely affects liver homeostasis in the double mutant @entity2 . CONCLUSIONS: Our results provide genetic evidence for a functional cross-talk of @entity10 and NF-kB/ @entity8 in hepatocytes, which protects the liver from @entity5 , @entity4 and @entity6 . Furthermore, the double mutant @entity2 represent a valuable animal model for @entity9 .

title: NF-kB/ XXXX and @entity10 cooperate to maintain hepatocyte integrity and to prevent development of @entity9 .

answer: @entity8


abstract: BACKGROUND _ AIMS: The liver is frequently challenged by toxins and reactive @entity3 species. Therefore, hepatocytes require cytoprotective strategies to cope with these insults. Since the transcription factors @entity10 and NF-kB regulate the cellular antioxidant defense system and important survival pathways, we determined their individual and overlapping functions in the liver. METHODS: We generated @entity2 lacking @entity10 and the NF-kB @entity8 / @entity8 subunit in hepatocytes and we analyzed their liver by using histopathology, immunohistochemistry, quantitative RT-PCR, Western blot and Oxyblot analysis. @entity0 @entity9 ( @entity9 ) were analyzed by immunohistochemistry. RESULTS: Loss of either @entity10 or NF-kB/ @entity8 had only a minor effect on liver homeostasis, but the double knockout @entity2 spontaneously developed @entity7 and @entity6 . Upon aging, more than one-third of the female double mutant @entity2 developed @entity1 , which histologically resemble @entity0 @entity9 , a @entity1 that predominantly occurs in @entity0 . The @entity2 @entity1 also recapitulated the immunohistochemical marker profile characteristic for @entity0 @entity9 . Moreover, pNRF2 and NF-kB @entity8 / @entity8 was not detectable in the nuclei of @entity9 @entity1 cells. The @entity2 phenotype was not due to a synergistic effect of both transcription factors on cytoprotective @entity10 target genes. Rather, loss of @entity10 or NF-kB/ @entity8 altered the expression of different genes, and the combination of these alterations likely affects liver homeostasis in the double mutant @entity2 . CONCLUSIONS: Our results provide genetic evidence for a functional cross-talk of @entity10 and NF-kB/ @entity8 in hepatocytes, which protects the liver from @entity5 , @entity4 and @entity6 . Furthermore, the double mutant @entity2 represent a valuable animal model for @entity9 .

title: NF-kB/ @entity8 and XXXX cooperate to maintain hepatocyte integrity and to prevent development of @entity9 .

answer: @entity10


abstract: INTRODUCTION: @entity2 ( @entity2 ) is not only one of the prevelant diseases with a high mortality risk but also has a high ratio of delayed diagnosis and misdiagnosis. In this study, it was aimed to determine the demographical characteristics, risk factors, clinical and laboratory findings of the @entity0 that were diagnosed as @entity2 at their first hospital visit and of the PE @entity0 who were misdiagnosed at their first admission. We aimed to investigate the factors which can leads to misdiagnosis of PE, and to determine the ways to avoid misdiagnosis. MATERIALS AND METHODS: One hundred @entity2 @entity0 who were admitted to University Hospital between the dates January 2007-December 2011 were included in the study. Clinical and laboratory findings of these @entity0 were evaluated. Among these @entity0 , 26 were misdiagnosed at their first admission but diagnosed accurately (as @entity2 ) in our hospital and 74 were diagnosed accurately. Two groups were compared with respect to various data of the @entity0 clinical and demographical characteristics. RESULTS: Between the two groups, there was no difference in terms of physical examination and laboratory findings. The @entity0 with the symptoms onset was over a week ago had a higher misdiagnosis rate (p= 0.002). The @entity0 with no risk of @entity2 had a higher misdiagnosis rate (p= 0.017). Misdiagnosis rate of the @entity0 with @entity1 was lower (p= 0.033) According to Geneva risk score, we observed that the misdiagnosis risk was reduced in the @entity0 with higher clinical probability (p= 0.011). CONCLUSION: In conclusion, misdiagnosis rate was found to be statistically significant in the @entity0 with low score according to the Geneva risk classification, and whose pre-diagnosis period lasted for more than a week and with no risk factors of @entity2 or @entity1 . We are in the opinion that considering these parameters will help to reduce in misdiagnosis of @entity2 cases.

title: [Misdiagnosis of XXXX and causes].

answer: @entity2


abstract: The @entity5 (cby) mutant is a previously undescribed skeletal mutation in the @entity0 . Breeding experiments showed that cby is a recessive mutant with complete viability, full penetrance and fertility in both sexes. Tests for allelism showed that the cby mutant is genetically unlike the somewhat similar mutants, stumpy ( @entity6 ), @entity3 (smc), @entity7 (bm), and @entity4 (cn). The defects seem to occur mainly in growth cartilage. Microradiography revealed increased height of the epiphyseal growth plate and irregular bone trabeculae in the metaphysis. Light microscopy showed disturbed columnar organization of proliferative chondrocytes and pronounced signs of cellular disintegration. The @entity2 zone, however, contained normally shaped chondrocytes arranged in regular columns. In spite of the normal cellular hypertrophy the pattern of cartilage mineralization was disturbed. The electron microscopy studies revealed very high amounts of matrix vesicles and numerous larger membrane coated structures in the extracellular matrix. Biochemical analysis of the affected growth cartilage revealed a slightly modified pattern of proteoglycan subpopulations and considerably longer chondroitin @entity1 chains when compared with controls. From the present study it can be concluded that the cby mutant is a genetically and morphologically distinct condition with characteristic, somewhat rickets-like stigmata. The pathogenetic mechanism underlying the condition remains to be clarified.

title: XXXX : a new autosomal recessive skeletal mutation producing dwarfism in the @entity0 .

answer: @entity5


abstract: The @entity5 (cby) mutant is a previously undescribed skeletal mutation in the @entity0 . Breeding experiments showed that cby is a recessive mutant with complete viability, full penetrance and fertility in both sexes. Tests for allelism showed that the cby mutant is genetically unlike the somewhat similar mutants, stumpy ( @entity6 ), @entity3 (smc), @entity7 (bm), and @entity4 (cn). The defects seem to occur mainly in growth cartilage. Microradiography revealed increased height of the epiphyseal growth plate and irregular bone trabeculae in the metaphysis. Light microscopy showed disturbed columnar organization of proliferative chondrocytes and pronounced signs of cellular disintegration. The @entity2 zone, however, contained normally shaped chondrocytes arranged in regular columns. In spite of the normal cellular hypertrophy the pattern of cartilage mineralization was disturbed. The electron microscopy studies revealed very high amounts of matrix vesicles and numerous larger membrane coated structures in the extracellular matrix. Biochemical analysis of the affected growth cartilage revealed a slightly modified pattern of proteoglycan subpopulations and considerably longer chondroitin @entity1 chains when compared with controls. From the present study it can be concluded that the cby mutant is a genetically and morphologically distinct condition with characteristic, somewhat rickets-like stigmata. The pathogenetic mechanism underlying the condition remains to be clarified.

title: @entity5 : a new autosomal recessive skeletal mutation producing dwarfism in the XXXX .

answer: @entity0


abstract: OBJECTIVE: Attenuation correction (AC) in fully integrated positron emission tomography (PET)/magnetic resonance (MR) systems plays a key role for the quantification of tracer uptake. The aim of this prospective study was to assess the accuracy of standardized uptake value (SUV) quantification using MR-based AC in direct comparison with computed tomography (CT)-based AC of the same PET data set on a large @entity0 population. MATERIALS AND METHODS: Sixty-six @entity0 (22 female; mean [SD], 61 [11] years) were examined by means of combined PET/CT and PET/MR ( @entity4 , @entity3 , or 68Ga-DOTATATE) subsequently. Positron emission tomography images from PET/MR examinations were corrected with MR-derived AC based on tissue segmentation (PET(MR)). The same PET data were corrected using CT-based attenuation maps ( -maps) derived from PET/CT after nonrigid registration of the CT to the MR-based  -map (PET(MRCT)). Positron emission tomography SUVs were quantified placing regions of interest or volumes of interest in 6 different body regions as well as PET-avid lesions, respectively. RESULTS: The relative differences of quantitative PET values when using MR-based AC versus CT-based AC were varying depending on the organs and body regions assessed. In detail, the mean (SD) relative differences of PET SUVs were as follows: -7.8% (11.5%), blood pool; -3.6% (5.8%), spleen; -4.4% (5.6%)/-4.1% (6.2%), liver; -0.6% (5.0%), muscle; -1.3% (6.3%), fat; -40.0% (18.7%), bone; 1.6% (4.4%), @entity2 ; -6.2% (6.8%), @entity1 ; and -1.9% (6.2%), soft tissue lesions. In 10 @entity2 , distinct overestimations greater than 5% were found (up to 10%). In addition, overestimations were found in 2 @entity1 and 1 soft tissue lesion adjacent to the lung (up to 28.0%). CONCLUSIONS: Results obtained using different PET tracers show that MR-based AC is accurate in most tissue types, with SUV deviations generally of less than 10%. In bone, however, underestimations can be pronounced, potentially leading to inaccurate SUV quantifications. In addition, SUV overestimations were found for some lesions close to lung borders. This has to be taken into account when comparing PET/CT- and PET/MR-derived SUVs.

title: Comparison of Positron Emission Tomography Quantification Using Magnetic Resonance- and Computed Tomography-Based Attenuation Correction in Physiological Tissues and Lesions: A Whole-Body Positron Emission Tomography/Magnetic Resonance Study in 66 XXXX .

answer: @entity0


abstract: UNASSIGNED: Hedgehog (Hh) signaling is critical in developmental osteogenesis, and recent studies suggest it may also play a role in regulating osteogenic gene expression in the post-natal setting. However, there is a void of studies directly assessing the effect of Hh inhibition on post-natal osteogenesis. This study utilized a cyclic loading-induced ulnar stress @entity1 model to evaluate the hypothesis that Hh signaling contributes to osteogenesis and angiogenesis during stress @entity1 healing. Immediately prior to loading, adult @entity0 were given @entity2 ( @entity2 - a selective Hh pathway inhibitor; 50mg/kg orally twice daily), or vehicle. Hh signaling was upregulated in response to stress @entity1 at 3days ( @entity12 , @entity5 expression), and was markedly inhibited by @entity2 at 1day and 3days in the loaded and non-loaded ulnae. @entity2 did not affect Hh ligand expression ( @entity6 , Ihh, @entity14 ) at 1day, but decreased @entity6 expression by 37% at 3days. @entity2 decreased woven bone volume (-37%) and mineral density (-17%) at 7days. Dynamic histomorphometry revealed that the 7day callus was composed predominantly of woven bone in both groups. The observed reduction in woven bone occurred concomitantly with decreased expression of @entity13 and @entity9 , but was not associated with differences in early cellular proliferation (as determined by callus PCNA staining at 3days), osteoblastic differentiation (Osx expression at 1day and 3days), chondrogenic gene expression ( @entity11 , @entity10 , and @entity8 expression at 1day and 3days), or bone resorption metrics (callus TRAP staining at 3days, @entity3 and @entity4 expression at 1day and 3days). To evaluate angiogenesis, vWF immunohistochemistry showed that @entity2 reduced @entity1 callus blood vessel density by 55% at 3days, which was associated with increased @entity7 gene expression (+30%). Dynamic histomorphometric analysis demonstrated that @entity2 also inhibited lamellar bone formation. Lamellar bone analysis of the loaded limb (directly adjacent to the woven bone callus) showed that @entity2 significantly decreased mineral apposition rate (MAR) and bone formation rate (BFR/BS) (-17% and -20%, respectively). Lamellar BFR/BS in the non-loaded ulna was also significantly decreased (-37%), indicating that Hh signaling was required for normal bone modeling. In conclusion, Hh signaling plays an important role in post-natal osteogenesis in the setting of stress @entity1 healing, mediating its effects directly through regulation of bone formation and angiogenesis.

title: Hedgehog signaling mediates woven bone formation and vascularization during stress XXXX healing.

answer: @entity1


abstract: OBJECTIVE: To review the mechanisms of action of @entity9 in pediatric @entity4 and their clinical indications. SOURCES: Review in the PubMed database, comprising the following terms in English: " @entity10 and @entity2 "; " @entity10 and @entity5 "; " @entity10 @entity8 and viral acute"; " @entity10 and @entity6 " and " @entity10 and non- @entity5 @entity7 ". SUMMARY OF THE FINDINGS: The spectrum of action of @entity9 includes production of inflammatory mediators, control of mucus hypersecretion, and modulation of host-defense mechanisms. The potential benefit of @entity10 antibiotics has been studied in a variety of @entity1 , such as @entity5 ( @entity5 ), @entity7 , @entity2 , acute @entity8 , and non- @entity5 @entity7 . Several studies have evaluated the benefits of @entity9 in @entity2 refractory to therapy, but the results are controversial and indications should be limited to specific phenotypes. In @entity11 , there is no consistent benefit in acute conditions, although recent data have shown an effect in recurrent wheezing prevention. In @entity0 with @entity5 results are also contradictory, but the consensus states there is a small clinical benefit, especially for @entity0 infected with @entity3 . There was also no positive action of @entity9 in @entity0 with post-infectious @entity6 . @entity0 with non- @entity5 @entity7 seem to have clear benefits regarding the use of @entity9 , which showed clinical advantages in parenchyma protection and lung function. CONCLUSIONS: The long-term use of @entity9 should be limited to highly selected situations, especially in @entity0 with @entity7 . Careful evaluation of the benefits and potential damage are tools for their indication in specific groups.

title: Use of @entity9 in pediatric XXXX : recent literature controversies.

answer: @entity1


abstract: OBJECTIVE: To review the mechanisms of action of @entity9 in pediatric @entity4 and their clinical indications. SOURCES: Review in the PubMed database, comprising the following terms in English: " @entity10 and @entity2 "; " @entity10 and @entity5 "; " @entity10 @entity8 and viral acute"; " @entity10 and @entity6 " and " @entity10 and non- @entity5 @entity7 ". SUMMARY OF THE FINDINGS: The spectrum of action of @entity9 includes production of inflammatory mediators, control of mucus hypersecretion, and modulation of host-defense mechanisms. The potential benefit of @entity10 antibiotics has been studied in a variety of @entity1 , such as @entity5 ( @entity5 ), @entity7 , @entity2 , acute @entity8 , and non- @entity5 @entity7 . Several studies have evaluated the benefits of @entity9 in @entity2 refractory to therapy, but the results are controversial and indications should be limited to specific phenotypes. In @entity11 , there is no consistent benefit in acute conditions, although recent data have shown an effect in recurrent wheezing prevention. In @entity0 with @entity5 results are also contradictory, but the consensus states there is a small clinical benefit, especially for @entity0 infected with @entity3 . There was also no positive action of @entity9 in @entity0 with post-infectious @entity6 . @entity0 with non- @entity5 @entity7 seem to have clear benefits regarding the use of @entity9 , which showed clinical advantages in parenchyma protection and lung function. CONCLUSIONS: The long-term use of @entity9 should be limited to highly selected situations, especially in @entity0 with @entity7 . Careful evaluation of the benefits and potential damage are tools for their indication in specific groups.

title: Use of XXXX in pediatric @entity1 : recent literature controversies.

answer: @entity9


abstract: UNASSIGNED: @entity1 ( @entity1 ) are common benign dermal connective tissue neoplasms that are mainly composed of loose fibrous tissue. However, their exact etiology is not fully understood. @entity2 is a major player in the biology and pathology of the skin and its appendages. It is linked to cell differentiation, proliferation, migration, and survival with pronounced effects on angiogenesis, blood flow, and tissue perfusion. This study aimed at investigating the possible role of @entity2 in @entity1 pathogenesis and correlating its expression with different clinical and histopathological parameters. Using immunohistochemical techniques, we examined 90 subjects. These included 60 @entity0 cases with @entity1 and 30 age-, gender- and Body Mass Index-matched normal subjects as a control group. @entity2 was overexpressed in @entity1 compared with normal skin (p   <   .001). Nuclear and nucleocytoplasmic patterns were significantly associated with cases both in epidermis (p   <   .04) and dermis (p   <   .001). Higher epidermal @entity2 H score was significantly associated with female gender (p   =   .004) and haphazard collagen arrangement (p   <   .03). Higher dermal @entity2 H score was significantly associated with smooth @entity1 (p   =   .01), dilated blood vessels (p   =   .04), presence of mast cells (MCs) (p   =   .002), presence of inflammatory cells (p   =   .004), and haphazard collagen arrangement (p   <   .001). In conclusion, @entity2 may play a role in @entity1 pathogenesis through its effects on keratinocytes, fibroblasts and vascular endothelium. Further studies are recommended to clarify the molecular interplay between @entity2 and MCs in ST pathogenesis. Further studies are also needed to determine the significance of its nuclear expression.

title: Immunohistochemical Evaluation of XXXX Role in Skin Tags.

answer: @entity2


abstract: PURPOSE: Dual acid-etching is widely used to modify dental implant topography and enhance early bone healing. This study evaluated the histomorphometric, biomechanical, and histological bone response to acid-etched ( @entity1 ) in comparison with grit-blasted/acid-etched (GB) and machined control (C) implants within sites of relatively low-bone remodeling rates. MATERIALS AND METHODS: Implant surface topography was evaluated by scanning electron microscopy and optical interferometry (IFM). Six adult male @entity0 (n = 6) received 72 Ti-6Al-4V implants (n = 24 per surface) in both ilium (n = 12 per bone bilaterally). The implants remained for 3 and 6 weeks in vivo. The histomorphometric parameters bone-implant contact (BIC) and bone area fraction occupancy (BAFO) were evaluated. Biomechanical analysis consisted of torque-to-interface failure. RESULTS: IFM analysis showed the highest average surface roughness for GB and the highest density of summits and developed surface area percentage (P < 0.01) for @entity1 . No difference was observed in BAFO for all groups in 3 and 6 weeks. Increased BIC and torque resistance were observed for @entity1 implants at both time points after implantation. CONCLUSIONS: Overall, improved bone-to-implant response was observed for the @entity1 implant surface.

title: Surface Characterization and In Vivo Evaluation of Dual Acid-Etched and Grit-Blasted/Acid-Etched Implants in XXXX .

answer: @entity0


abstract: AIMS: Soil @entity1 (As) contamination of food-chains and public health can be mitigated through fungal bioremediation. To enumerate culturable soil fungi, soils were collected from the As-contaminated paddy fields (3-35 mg kg(-1) ) of the middle Indo-Gangetic Plains. METHODS AND RESULTS: Total 54 fungal strains were obtained and identified at their molecular level. All strains were tested for As tolerance (from 100 to 10,000 mg l(-1) @entity2 ). Fifteen fungal strains, tolerant to 10,000 mg l(-1) @entity2 , were studied for As removal in-vivo for 21 days by cultivating them individually in @entity0 dextrose broth enriched with 10 mg l(-1) As. The bioaccumulation of As in fungal biomass ranged from 0  023 to 0  259 g kg(-1). The biovolatilized As ranged from 0  23 to 6  4 mg kg(-1). CONCLUSIONS: Higher As bioaccumulation and biovolatilization observed in the seven fungal strains, @entity3 FNBR_L35; Fusarium sp. FNBR_B7, FNBR_LK5 and FNBR_B3; @entity4 FNBR_LK1; Rhizomucor variabilis sp. FNBR_B9; and @entity4 sp. FNBR_BA5. These fungal strains were also tested and found suitable for significant plant growth promotion in the calendula, withania and oat plants in a greenhouse based pot experiment. SIGNIFICANCE AND IMPACT OF STUDY: These fungal strains can be used for As remediation in As-contaminated agricultural soils.

title: Soil fungi for mycoremediation of XXXX pollution in agriculture soils.

answer: @entity1


abstract: BACKGROUND: Early treatment of @entity2 ( @entity2 ) is necessary for a successful @entity1 ( @entity1 ) control program. OBJECTIVES: The objective of this study was to determine total treatment delay and its associated factors among @entity2 @entity0 in Ahvaz. @entity0 AND METHODS: A retrospective study was performed among newly diagnosed @entity2 cases registered in 2010 at the Ahvaz health center. Total treatment delay was defined as the time interval between the onsets of cough to the initiation of anti- @entity1 treatment. @entity1 diagnosis and treatment was based on the national @entity1 program (NTP). Data analysis was performed using the SPSS software by chi-square and Fisher's exact test with odds ratio (OR) and 95% confidence interval (CI). RESULTS: The mean age of the @entity0 was 38.9    12.3 years; 83 were male and 56 were female. Of the 139 smear positive @entity2 cases, 91 (65.5%) cases had received delayed-treatment. The mean time between onset of symptoms, diagnosis and treatment was 73 days (median: 48 days, range: 4-570 days). Female gender (OR (95% CI): 2.9, 1.03-8.23, P = 0.02), smoking (OR (95% CI): 0.49, 0.22-0.96, P = 0.04) and receiving immunosuppressive drugs (OR (95% CI): 8.18, 1.09-75.31, P < 0.05) were associated with longer delayed time. CONCLUSIONS: Delayed diagnosis and treatment of @entity1 appears to be the main problem in the @entity1 control program of the region. Delayed time is significantly associated with female gender, smoking and immunosuppressive drugs.

title: Factors associated with delay in diagnosis and treatment of XXXX .

answer: @entity2


abstract: BACKGROUND: Moderate and chronic @entity7 is a common disease affecting the hand. Treatment can be effective but the affection is often recurrent, especially as an @entity4 . Also, this condition may be complicated by a Candida s pp or @entity2 . Therefore, general preventive measures can be useful in maintaining healing. OBJECTIVE: T he aim of this study was to investigate the e fficacy and tolerability of a new combination of topical medications in the treatment and prevention of moderate and chronic @entity7 . This formulation includes an insulating polymer ( @entity9 -cell barrier), two topical antifungals (octopirox and climbazole) and a molecule with anti-inflammatory activity (Corticoid - like Repair). @entity0 AND METHODS: 30 adult subjects (age, 16--78 years; 24 females and 6 males) affected by moderate or chronic @entity7 with or without nail alterations associated were evaluated. Included in the study were @entity0 with @entity3 (8); @entity8 (19); psoriatic @entity7 (2 @entity0 ); @entity5 (1 @entity0 ). Sometimes Candida spp or bacteria overlap with @entity7 (16 @entity0 positive for Candida spp and 4 @entity0 with @entity2 ), sometimes infectious @entity7 was not associated with @entity1 of the hands. All 30 subjects were treated with a new formulation of cream, three applications per day for 2 months. In 8 @entity0 with proven and severe @entity6 of the nails was added oral fluconazole 100 mg for 20 days. All @entity0 with @entity2 have taken clarithromycin 500 mg twice daily for six days. @entity0 were then followed for 8 weeks . RESULTS: After two months of treatment, 26 @entity0 responded to therapy. In particular, the treatment evaluation at the end of the follow--up period showed a clinical cure in 46,6 % (14 @entity0 ), improvement in 40 % (12 @entity0 ), and failure in 13,4% (4 @entity0 ). There was a side effect in 2 @entity0 of moderate skin irritation, but the drug was not discontinued. CONCLUSIONS: Results of the present study, based on its safety, effectiveness and i nnovative features, indicate that t his combination of topical cream may be considered as a new alternative for treatment and prevention of @entity7 , especially in case of @entity4 where prolonged treatment and continuous prevention are needed.

title: Treatment and prevention of XXXX using a new combination of topicals: 30 cases report.

answer: @entity7


abstract: UNASSIGNED: @entity3 resistance in the pathogenic @entity0 @entity2 poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the @entity3 resistance. ERG11 of 23 isolates (8 susceptible and 15 resistant) and 6 standard strains of @entity2 were amplified and sequenced. Nineteen missense mutations were detected. Two mutations, @entity4 ( @entity5 ) and @entity6 ( @entity7 ), coexisted exclusively in 14 @entity1 -resistant isolates. To identify the resistance mechanisms in the isolates with @entity4 and @entity6 mutations, we compared the expression of 5 resistance-related genes in the 14 @entity3 -resistant isolates with those in the susceptible type strain ATCC 10231, @entity0 AD/CDR1 and AD/CDR2. The tested values of mRNA transcription of CDR1 and CDR2 were higher than that of control strain, while the semi-quantified Cdr1p values were not higher in all of the 14 resistant isolates. And the data analyzed with t test suggest that both of the differences are significant (P  <  0.0005) when the resistant isolates are considered as a whole. Cdr2p was up-regulated in 5 isolates, and down-regulated or even undetectable in the remaining 9 isolates. The transcription of ERG11, MDR1, and FLU1 varied in these isolates. These data suggested that overexpression of the five genes might not be the reason of resistance in the 14 isolates with @entity4 and @entity6 , especially in the 5 isolates (GZ09, GZ15, GZ16, GZ58, and 4263) in which neither translation of Cdr1p/Cdr2p nor transcription of ERG11, MDR1, or FLU1 was detected up-regulated. The results suggest that Erg11p conformational change due to the point mutations is most likely responsible for the @entity3 resistance in these isolates.

title: ERG11 mutations and expression of resistance genes in XXXX -resistant @entity2 isolates.

answer: @entity1


abstract: UNASSIGNED: @entity3 resistance in the pathogenic @entity0 @entity2 poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the @entity3 resistance. ERG11 of 23 isolates (8 susceptible and 15 resistant) and 6 standard strains of @entity2 were amplified and sequenced. Nineteen missense mutations were detected. Two mutations, @entity4 ( @entity5 ) and @entity6 ( @entity7 ), coexisted exclusively in 14 @entity1 -resistant isolates. To identify the resistance mechanisms in the isolates with @entity4 and @entity6 mutations, we compared the expression of 5 resistance-related genes in the 14 @entity3 -resistant isolates with those in the susceptible type strain ATCC 10231, @entity0 AD/CDR1 and AD/CDR2. The tested values of mRNA transcription of CDR1 and CDR2 were higher than that of control strain, while the semi-quantified Cdr1p values were not higher in all of the 14 resistant isolates. And the data analyzed with t test suggest that both of the differences are significant (P  <  0.0005) when the resistant isolates are considered as a whole. Cdr2p was up-regulated in 5 isolates, and down-regulated or even undetectable in the remaining 9 isolates. The transcription of ERG11, MDR1, and FLU1 varied in these isolates. These data suggested that overexpression of the five genes might not be the reason of resistance in the 14 isolates with @entity4 and @entity6 , especially in the 5 isolates (GZ09, GZ15, GZ16, GZ58, and 4263) in which neither translation of Cdr1p/Cdr2p nor transcription of ERG11, MDR1, or FLU1 was detected up-regulated. The results suggest that Erg11p conformational change due to the point mutations is most likely responsible for the @entity3 resistance in these isolates.

title: ERG11 mutations and expression of resistance genes in @entity1 -resistant XXXX isolates.

answer: @entity2


abstract: PURPOSE: To review outcomes of @entity0 with stage I @entity2 ( @entity2 ) following the introduction of stereotactic body radiation therapy (SBRT). METHODS: SBRT cases were linked to the @entity1 registry database along with clinical, treatment and health service parameters for n=2146 cases of stage I @entity2 diagnosed between 2005 and 2011. The pre-diagnosis Aggregated Clinical Risk Grouping score (ACRG3) was used as a proxy for pre-treatment @entity0 comorbidity. A Cox regression model and the concordance statistic (C-statistic) were used to examine variables predicted for @entity3 ( @entity3 ). RESULTS: The SBRT utilization rate increased annually with superior @entity3 to conventional RT (median survival [MS] of 39.4 VS. 23.5months, P<0.001) despite higher ACRG3 scores. Surgical @entity0 were younger, had lower ACRG3, achieving MS of 69.6months. Regression analysis indicated both Surgery (hazard ratio [HR]=0.23, 95% CI: 0.18-0.28) and SBRT (HR=0.33, 95% CI: 0.21-0.51) remained most strongly associated with @entity3 . ACRG3 (HR=0.79, P<0.001) and age (HR=0.83, P=0.03) were independently associated with @entity3 . The @entity3 model was associated with the C-statistic at 0.86, 95% CI: 0.81-0.90. CONCLUSION: In stage I @entity2 @entity0 treated with surgery have the best survival. SBRT demonstrates improved @entity3 compared to conventional RT. C-statistic result demonstrates discrimination of treatment selection factors on @entity3 .

title: Outcomes in stage I XXXX following the introduction of stereotactic body radiotherapy in Alberta - A population-based study.

answer: @entity2


abstract: UNASSIGNED: The mid-posterior part of the insula is involved in processing bodily sensations and urges and is activated during tic generation in @entity3 . The dorsal anterior part of the insula, however, integrates sensory and emotional information with cognitive valuation and is implicated in interoception. The right dorsal anterior insula also participates in urge suppression in healthy subjects. This study examined the role of the right dorsal anterior insula in the urge to @entity2 . Resting-state functional magnetic resonance imaging was performed in 13 adult Tourette @entity0 and 13 matched controls. The role of the right dorsal anterior insula within the urge-tic network was investigated using graph theory-based neural network analysis. The functional connectivity of the right dorsal anterior insula was also correlated with urge and tic severity. Even though the @entity0 did not exhibit any overt tics, the right dorsal anterior insula demonstrated higher connectivity, especially with the frontostriatal nodes of the urge-tic network in @entity0 compared with controls. The functional connectivity between the right dorsal anterior insula and bilateral supplementary motor area also correlated positively with urge severity in @entity0 . These results suggest that the right dorsal anterior insula is part of the urge-tic network and could influence the urge- and tic-related cortico-striato-thalamic regions even during rest in @entity3 . It might be responsible for heightened awareness of bodily sensations generating premonitory urges in @entity3 .    2015 International Parkinson and @entity1 Society.

title: Role of the right dorsal anterior insula in the urge to XXXX .

answer: @entity2


abstract: In this study, mRNA expression patterns during @entity1 in the peritoneal cavity were investigated. To this purpose, the mRNA expression patterns of fiber-induced @entity3 and of fiber-treated tissues were compared to untreated tissues, respectively. Suppression subtractive hybridization (SSH) and an array hybridization assay were used to perform differential display analyses. Genes found to be expressed differentially mainly represent proteins of signal transduction pathways and regulatory proteins of the cell cycle. The genes for components of the AP-1 transcription factor, c-jun, @entity4 , and @entity6 ) are upregulated in nontumorous tissue treated with @entity2 . These data confirm in vivo the involvement of AP-I expression as response to fiber treatment. In addition, osteopontin, @entity7 , and integrin-linked kinase were upregulated in @entity0 and in treated tissues. These genes code for proteins involved in the signal transduction from the extracellular matrix to the nucleus. Using integrin-specific inhibitors, the apoptotic effects of @entity5 fibers could be suppressed significantly. From these results we hypothesize that direct effects of the fibers on the target tissue are mediated by interaction of the fibers with the extracellular matrix molecules.

title: Differential Display Analysis of Fiber-Induced XXXX in Rat: Clue for Involvement of Integrin-Mediated Signal Transduction.

answer: @entity1


abstract: To take advantage of live @entity4 viruses (rVSVs) as vaccine vectors for their high yield and for their induction of strong and long-lasting immune responses, it is necessary to make live vaccine vectors safe for use without losing their immunogenicity. We have generated safer and highly efficient recombinant VSV vaccine vectors by combining the @entity5 mutation in the M gene of serotype VSV-Indiana (VSVInd) with a temperature-sensitive mutation (tsO23) of the VSVInd Orsay strain. In addition, we have generated two new serotype VSV-New Jersey (VSVNJ) vaccine vectors by combining @entity6 and @entity5 mutations with @entity7 and @entity8 mutations in the M gene, rVSVNJ( @entity9 ) [rVSVNJ(GMM)] and VSVNJ( @entity10 ) [rVSVNJ(GMML)]. The combined mutations @entity11 , @entity5 , and @entity12 in the M protein of VSVInd significantly reduced the burst size of the virus by up to 10,000-fold at 37  C without affecting the level of protein expression. BHK21 cells and SH-SY5Y @entity0 @entity3 cells infected with rVSVInd(GML), rVSVNJ(GMM), and rVSVNJ(GMML) showed significantly reduced cytopathic effects in vitro at 37  C, and @entity1 injected with 1 million infectious virus particles of these mutants into the brain showed no @entity2 or any other adverse effects. In order to increase the stability of the temperature-sensitive mutant, we have replaced the phenylalanine with alanine. This will change all three nucleotides from UUG (leucine) to GCA (alanine). The resulting @entity13 mutant showed the temperature-sensitive phenotype of rVSVInd(GML) and increased stability. Twenty consecutive passages of rVSVInd(GML) with an @entity13 mutation did not convert back to leucine (UUG) at position 111 in the M protein gene. IMPORTANCE: Recombinant @entity4 viruses as live vaccine vectors are very effective in expressing foreign genes and inducing adaptive T cell and B cell immune responses. As with any other live viruses in @entity0 or animals, the use of live rVSVs as vaccine vectors demands the utmost safety. Our strategy to attenuate rVSVInd by utilizing a temperature-sensitive assembly-defective mutation of @entity13 and combining it with an @entity5 mutation in the M protein of rVSVInd significantly reduced the pathogenicity of the virus while maintaining highly effective virus production. We believe our new temperature-sensitive M gene mutant of rVSVInd(GML) and M gene mutants of rVSVNJ(GMM) and rVSVNJ(GMML) add excellent vaccine vectors to the pool of live viral vectors.

title: Creation of matrix protein gene variants of two serotypes of XXXX virus as prime-boost vaccine vectors.

answer: @entity4


abstract: A genetically determined hyperlipidemic strain of New Zealand White @entity2 that has features in common with combined @entity3 in @entity0 has been identified. The morphologic findings in a few animals fed a normal chow diet are reported. These consisted of macroscopically visible aortic intimal elevations found in the greatest number in the descending thoracic aorta. The plaques showed the presence of a cell population consisting of modified smooth muscle cells and lipid-laden macrophages. The lesion bases were @entity1 and acellular, and some showed the presence of @entity4 . Scanning electron microscopy revealed numerous monocytes attached to the endothelium. Endothelial defects were common, and these were filled with swollen and "ruffled" macrophages. Transmission electron microscopy confirmed the presence of lipid-laden cells penetrating between adjacent endothelial cells. These findings resemble those reported in a number of different animal species after dietary induction of @entity3 . This strain is a useful new model for the study of atherogenesis.

title: Hereditary hyperlipidemia and atherosclerosis in the XXXX due to overproduction of lipoproteins. II. Preliminary report of arterial pathology.

answer: @entity2


abstract: INTRODUCTION: @entity5 is a chronic @entity1 caused by aerobic branching actinomycetes. Its clinical features are firm tumefaction of the affected site and the presence of abscesses, nodules, and sinuses that drain a seropurulent exudate containing filamenting granules. Cutaneous @entity5 has traditionally been deemed uncommon in the northern part of India, but recent studies have refuted this long-held notion. Thus, clinicians have to be more vigilant when they come across @entity0 with long-standing cutaneous lesions with typical mycetomic features, as early diagnosis and treatment hold the key to a cure. MATERIALS AND METHODS: This prospective study was carried out from June 2009 to December 2012 and comprises 13 cases of chronic nonhealing ulcers of the lower limb subsequently diagnosed as @entity5 . Socioetiological aspects, prevalence, early diagnosis, and treatment modalities of this condition are described in the study along with a simple, yet inclusive, scoring system to evaluate the post-treatment results. RESULTS: Ten out of 13 cases with clinical suspicion of @entity5 were diagnosed with the condition. A majority of these diagnosed @entity0 were middle aged and belonged to lower socioeconomic status. There was no sexual preponderance. Early treatment in the form of modified Welsh regime ( @entity4 + @entity2 + @entity3 ) was started and showed acceptable results. Post-treatment outcomes were measured on the basis of a new scoring system (Masoodi's score) devised by the authors. Two @entity0 had a score of > 7 (good), 5 @entity0 had a score of 4-6 (fair), and 3 @entity0 had a score of  <= 3 (poor). CONCLUSION: Correct identification of the infective aetiological agent is imperative to direct therapy against @entity5 . Treatment success depends on an early diagnosis and instigation of treatment. Efficacy of chemotherapy, if started after an early diagnosis in the form of modified Welsh regime, produces acceptable results in the form of clinical and physical remission or cure. The functional and cosmetic parameters do not respond as well to treatment and the authors propose a new scoring system which takes into account the post-treatment results in totality.

title: XXXX Leg Ulcers in North India.

answer: @entity5


abstract: AIM: To compare the long-term clinical outcome of turned vs. moderately rough implants. MATERIALS AND METHODS: @entity0 treated with implants in the edentulous mandible and/or maxilla were invited for a clinical examination. After prosthesis removal, the pocket depth was measured and the @entity1 scored. Also, a new radiograph was taken for @entity2 evaluation. @entity0 were also requested to rate their satisfaction with the treatment. RESULTS: One hundred and ninety-seven implants in 33 @entity0 were evaluated. After a mean follow-up of 172  months (SD 42, range 120-252), the mean loss was 1.61  mm (SD 1.35, range 0.00-8.25). @entity2 was higher in the maxilla compared to the mandible (P  <  0.001), and at implants, that was restored on implant level (P  =  0.003). Multivariate analyses demonstrated a significant effect of implant surface roughness and time of loading on @entity2 . Smoking, on the other hand, did not affect the outcome. Mean pocket probing depth was 3.64  mm (SD 0.96, range 1.25-7.25). A total of 4.1% of the implants demonstrated signs of @entity3 . The overall @entity0 satisfaction rate was 98.5%. CONCLUSION: Implant treatment in the @entity4 has a predictable long-term outcome with limited complications.

title: Long-term retrospective follow-up of turned and moderately rough implants in the XXXX .

answer: @entity4


abstract: A case of @entity5 showing various heteroptics due to @entity3 of the right parieto-occipital lobe was reported. The @entity0 was 48-year-old male. Angiography revealed an obstruction of the right internal carotid artery, @entity2 of the right posterior communicating artery, and obstructions of the right parieto-occipital artery and calcarine artery. A low density area was found in right occipital lobe by CT. MRI clearly identified lesions in the right cuneus and precuneus. Pseudopsia in the left homonymous quadrantanopsia, various types of @entity1 in the remaining visual field, and moreover, palinopsia were existed. @entity1 was recognized in the early stage after the onset, while the pseudopsia was recognized about one month after the onset. Both abnormalities tended to improve from the peripheral region with the improvement of the defect in the visual field. Administration of @entity4 resulted in an improvement in the pseudopsia but it resulted in an aggravation in the @entity1 . Thus, the mechanisms of development of this phenomena were thought to be different from each other. It was found by dynamic CT that the blood flow in the primary visual cortex was rather increased in the affected site in comparison with that in the healthy site. It was speculated that the pseudopsia in the defective region of the visual field reflected a pathological repair process represented by a development of the collateral circulation. On the other hand, the @entity1 was thought to originate from visual unstability due to incomplete damage of the visual pathway at the affected site.

title: [A case of XXXX showing various heteroptics due to @entity3 of right parieto-occipital lobe].

answer: @entity5


abstract: A case of @entity5 showing various heteroptics due to @entity3 of the right parieto-occipital lobe was reported. The @entity0 was 48-year-old male. Angiography revealed an obstruction of the right internal carotid artery, @entity2 of the right posterior communicating artery, and obstructions of the right parieto-occipital artery and calcarine artery. A low density area was found in right occipital lobe by CT. MRI clearly identified lesions in the right cuneus and precuneus. Pseudopsia in the left homonymous quadrantanopsia, various types of @entity1 in the remaining visual field, and moreover, palinopsia were existed. @entity1 was recognized in the early stage after the onset, while the pseudopsia was recognized about one month after the onset. Both abnormalities tended to improve from the peripheral region with the improvement of the defect in the visual field. Administration of @entity4 resulted in an improvement in the pseudopsia but it resulted in an aggravation in the @entity1 . Thus, the mechanisms of development of this phenomena were thought to be different from each other. It was found by dynamic CT that the blood flow in the primary visual cortex was rather increased in the affected site in comparison with that in the healthy site. It was speculated that the pseudopsia in the defective region of the visual field reflected a pathological repair process represented by a development of the collateral circulation. On the other hand, the @entity1 was thought to originate from visual unstability due to incomplete damage of the visual pathway at the affected site.

title: [A case of @entity5 showing various heteroptics due to XXXX of right parieto-occipital lobe].

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) is a common disease causing significant socioeconomic burden. @entity4 @entity0 , commonly smokers develop resistance to inhaled @entity2 attributed to deficiency of @entity9 ( @entity9 ). The study of relationship between systemic @entity1 and functional performance demonstrated that increased CRP level is inversely related to six minute walk distance (SMWD) and Forced Expired Volume in one second (FEV1). @entity6 restores @entity9 activity thereby unlocking @entity3 resistance and potentiating inhaled corticosteroids (ICS) action culminating in reduced airway @entity1 and mortality. AIM: To study the effects of addition of @entity6 to the combination of @entity8 plus @entity7 on various objective and subjective parameters in moderate to severe @entity4 @entity0 and to assess the safety profile of the combination. Setting and Study design: A single blinded, prospective, randomized, placebo controlled study at a tertiary care hospital in Jaipur, India. MATERIALS AND METHODS: Fifty eight @entity0 diagnosed with moderate to severe @entity4 were randomized into two groups. Group A @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with @entity6 while group B @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with placebo tablets. Both groups were followed up on 15th, 30th _60th day. During every visit all @entity0 were assessed subjectively (symptom scoring) and objectively (spirometry, CRP, SMWT) and adverse effects if any were recorded. The obtained data subject to statistical analysis using"Graph pad Instat3" software. RESULTS: Statistically significant improvement with a decline in total symptom score (p < 0.0001) was found with respect to "Night symptoms"_"SOB on rising" in group A. @entity6 group showed significant improvement in SMWD and FEV1.Mean fall in CRP was greater in Group A (not statistically significant). No side effects requiring withdrawal of drug were noted with @entity6 . CONCLUSION: Addition of @entity6 to @entity8 plus @entity7 reduces @entity5 , improves exercise performance and pulmonary functions in moderate to severe @entity4 . Further studies are required to explore if reduced dosage would have equal efficacy with better safety and tolerability profile.

title: The Study of Efficacy, Tolerability and Safety of XXXX Given Along with @entity8 Plus @entity7 in @entity4 .

answer: @entity6


abstract: BACKGROUND: @entity4 ( @entity4 ) is a common disease causing significant socioeconomic burden. @entity4 @entity0 , commonly smokers develop resistance to inhaled @entity2 attributed to deficiency of @entity9 ( @entity9 ). The study of relationship between systemic @entity1 and functional performance demonstrated that increased CRP level is inversely related to six minute walk distance (SMWD) and Forced Expired Volume in one second (FEV1). @entity6 restores @entity9 activity thereby unlocking @entity3 resistance and potentiating inhaled corticosteroids (ICS) action culminating in reduced airway @entity1 and mortality. AIM: To study the effects of addition of @entity6 to the combination of @entity8 plus @entity7 on various objective and subjective parameters in moderate to severe @entity4 @entity0 and to assess the safety profile of the combination. Setting and Study design: A single blinded, prospective, randomized, placebo controlled study at a tertiary care hospital in Jaipur, India. MATERIALS AND METHODS: Fifty eight @entity0 diagnosed with moderate to severe @entity4 were randomized into two groups. Group A @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with @entity6 while group B @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with placebo tablets. Both groups were followed up on 15th, 30th _60th day. During every visit all @entity0 were assessed subjectively (symptom scoring) and objectively (spirometry, CRP, SMWT) and adverse effects if any were recorded. The obtained data subject to statistical analysis using"Graph pad Instat3" software. RESULTS: Statistically significant improvement with a decline in total symptom score (p < 0.0001) was found with respect to "Night symptoms"_"SOB on rising" in group A. @entity6 group showed significant improvement in SMWD and FEV1.Mean fall in CRP was greater in Group A (not statistically significant). No side effects requiring withdrawal of drug were noted with @entity6 . CONCLUSION: Addition of @entity6 to @entity8 plus @entity7 reduces @entity5 , improves exercise performance and pulmonary functions in moderate to severe @entity4 . Further studies are required to explore if reduced dosage would have equal efficacy with better safety and tolerability profile.

title: The Study of Efficacy, Tolerability and Safety of @entity6 Given Along with XXXX Plus @entity7 in @entity4 .

answer: @entity8


abstract: BACKGROUND: @entity4 ( @entity4 ) is a common disease causing significant socioeconomic burden. @entity4 @entity0 , commonly smokers develop resistance to inhaled @entity2 attributed to deficiency of @entity9 ( @entity9 ). The study of relationship between systemic @entity1 and functional performance demonstrated that increased CRP level is inversely related to six minute walk distance (SMWD) and Forced Expired Volume in one second (FEV1). @entity6 restores @entity9 activity thereby unlocking @entity3 resistance and potentiating inhaled corticosteroids (ICS) action culminating in reduced airway @entity1 and mortality. AIM: To study the effects of addition of @entity6 to the combination of @entity8 plus @entity7 on various objective and subjective parameters in moderate to severe @entity4 @entity0 and to assess the safety profile of the combination. Setting and Study design: A single blinded, prospective, randomized, placebo controlled study at a tertiary care hospital in Jaipur, India. MATERIALS AND METHODS: Fifty eight @entity0 diagnosed with moderate to severe @entity4 were randomized into two groups. Group A @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with @entity6 while group B @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with placebo tablets. Both groups were followed up on 15th, 30th _60th day. During every visit all @entity0 were assessed subjectively (symptom scoring) and objectively (spirometry, CRP, SMWT) and adverse effects if any were recorded. The obtained data subject to statistical analysis using"Graph pad Instat3" software. RESULTS: Statistically significant improvement with a decline in total symptom score (p < 0.0001) was found with respect to "Night symptoms"_"SOB on rising" in group A. @entity6 group showed significant improvement in SMWD and FEV1.Mean fall in CRP was greater in Group A (not statistically significant). No side effects requiring withdrawal of drug were noted with @entity6 . CONCLUSION: Addition of @entity6 to @entity8 plus @entity7 reduces @entity5 , improves exercise performance and pulmonary functions in moderate to severe @entity4 . Further studies are required to explore if reduced dosage would have equal efficacy with better safety and tolerability profile.

title: The Study of Efficacy, Tolerability and Safety of @entity6 Given Along with @entity8 Plus @entity7 in XXXX .

answer: @entity4


abstract: BACKGROUND: @entity4 ( @entity4 ) is a common disease causing significant socioeconomic burden. @entity4 @entity0 , commonly smokers develop resistance to inhaled @entity2 attributed to deficiency of @entity9 ( @entity9 ). The study of relationship between systemic @entity1 and functional performance demonstrated that increased CRP level is inversely related to six minute walk distance (SMWD) and Forced Expired Volume in one second (FEV1). @entity6 restores @entity9 activity thereby unlocking @entity3 resistance and potentiating inhaled corticosteroids (ICS) action culminating in reduced airway @entity1 and mortality. AIM: To study the effects of addition of @entity6 to the combination of @entity8 plus @entity7 on various objective and subjective parameters in moderate to severe @entity4 @entity0 and to assess the safety profile of the combination. Setting and Study design: A single blinded, prospective, randomized, placebo controlled study at a tertiary care hospital in Jaipur, India. MATERIALS AND METHODS: Fifty eight @entity0 diagnosed with moderate to severe @entity4 were randomized into two groups. Group A @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with @entity6 while group B @entity0 received @entity8 24 g plus @entity7 800 g daily in divided doses along with placebo tablets. Both groups were followed up on 15th, 30th _60th day. During every visit all @entity0 were assessed subjectively (symptom scoring) and objectively (spirometry, CRP, SMWT) and adverse effects if any were recorded. The obtained data subject to statistical analysis using"Graph pad Instat3" software. RESULTS: Statistically significant improvement with a decline in total symptom score (p < 0.0001) was found with respect to "Night symptoms"_"SOB on rising" in group A. @entity6 group showed significant improvement in SMWD and FEV1.Mean fall in CRP was greater in Group A (not statistically significant). No side effects requiring withdrawal of drug were noted with @entity6 . CONCLUSION: Addition of @entity6 to @entity8 plus @entity7 reduces @entity5 , improves exercise performance and pulmonary functions in moderate to severe @entity4 . Further studies are required to explore if reduced dosage would have equal efficacy with better safety and tolerability profile.

title: The Study of Efficacy, Tolerability and Safety of @entity6 Given Along with @entity8 Plus XXXX in @entity4 .

answer: @entity7


abstract: UNASSIGNED: To determine the proteomic-level responses of drought tolerant wild @entity5 (Triticum boeoticum), physiological and comparative proteomic analyses were conducted using the roots and the leaves of control and short term drought-stressed plants. Drought stress was imposed by transferring hydroponically grown seedlings at the 3-leaf stage into 1/2 Hoagland solution containing 20% @entity1 for 48 h. Root and leaf samples were separately collected at 0 (control), 24, and 48 h of drought treatment for analysis. Physiological analysis indicated that @entity3 ( @entity4 ) level was greatly increased in the drought-treated plants, but the increase was greater and more rapid in the leaves than in the roots. The net photosynthetic rate of the wild @entity5 leaves was significantly decreased under short-term drought stress. The deleterious effects of drought on the studied traits mainly targeted photosynthesis. Comparative proteomic analysis identified 98 and 85 differently changed protein spots (DEPs) (corresponding to 87 and 80 unique proteins, respectively) in the leaves and the roots, respectively, with only 6 mutual unique proteins in the both organs. An impressive 86% of the DEPs were implicated in detoxification and defense, @entity0 metabolism, @entity6 and @entity2 metabolism, proteins metabolism, chaperones, transcription and translation, photosynthesis, @entity7 metabolism, and signal transduction. Further analysis revealed some mutual and tissue-specific responses to short-term drought in the leaves and the roots. The differences of drought-response between the roots and the leaves mainly included that signal sensing and transduction-associated proteins were greatly up-regulated in the roots. Photosynthesis and @entity0 fixation ability were decreased in the leaves. Glycolysis was down-regulated but PPP pathway enhanced in the roots, resulting in occurrence of complex changes in energy metabolism and establishment of a new homeostasis. Protein metabolism was down-regulated in the roots, but enhanced in the leaves. These results will contribute to the existing knowledge on the complexity of root and leaf protein changes that occur in response to drought, and also provide a framework for further functional studies on the identified proteins.

title: Physiological and Comparative Proteomic Analysis Reveals Different Drought Responses in Roots and Leaves of Drought-Tolerant Wild XXXX (Triticum boeoticum).

answer: @entity5


abstract: PURPOSE: The aim of this study was to estimate the effective dose 90% (ED90) of @entity8 to provide adequate uterine tone at Cesarean delivery (CD) for @entity6 . METHODS: We conducted a double-blind dose-finding study of @entity8 using a biased-coin up-and-down design in @entity0 undergoing CD for @entity6 under epidural anesthesia. Forty healthy term pregnant @entity0 who had received at least three hours of @entity2 infusion during labour were recruited for the study. @entity8 was administered intravenously upon delivery of the anterior shoulder of the fetus. The first @entity0 received 20    g, and the dose for the subsequent @entity0 was determined according to the response of the previous @entity0 as per the biased-coin allocation scheme using increments or decrements of 20    g (maximum 140    g). Uterine tone was assessed by the obstetrician and rated as satisfactory or unsatisfactory throughout the intraoperative period. The primary outcome was satisfactory uterine tone with no need for additional uterotonic drugs intraoperatively. Secondary outcomes included use of additional uterotonic drugs postoperatively in the first 24  hr, estimated @entity1 , and adverse effects. RESULTS: The ED90 of @entity8 to produce adequate uterine tone was estimated at 121    g (95% confidence interval [CI]: 111 to 130; 99% CI: 108 to 133) using the truncated @entity7 ( @entity7 ) method. The isotonic estimator of ED90 was 140    g; however, the observed response rate across all doses was  <  90%. Also, the 95% CI of the @entity7 estimator is likely to have lower than expected coverage, while the 99% CI may have about 90% coverage. Therefore, these results should be interpreted with caution. The overall median (range) estimated @entity1 was 1,014 (104-2,436)  mL. The overall incidence of @entity3 and @entity4 were 45% and 57.5%, respectively. At a dose of 140    g, the incidence of @entity4 and intraoperative @entity5 was 76% and 14%, respectively. CONCLUSION: The ED90 of @entity8 at CD for @entity6 , as determined in our study, should be interpreted with caution since it may be underestimated. This dose is higher than the currently recommended dose of 100    g at elective CD and should not be used routinely given the uncertainty regarding its efficacy and the high incidence of @entity5 at higher doses. This trial was registered at ClinicalTrials.gov, number: NCT01725243.

title: XXXX at Cesarean delivery for @entity6 : a sequential allocation trial to determine the effective dose.

answer: @entity8


abstract: PURPOSE: The aim of this study was to estimate the effective dose 90% (ED90) of @entity8 to provide adequate uterine tone at Cesarean delivery (CD) for @entity6 . METHODS: We conducted a double-blind dose-finding study of @entity8 using a biased-coin up-and-down design in @entity0 undergoing CD for @entity6 under epidural anesthesia. Forty healthy term pregnant @entity0 who had received at least three hours of @entity2 infusion during labour were recruited for the study. @entity8 was administered intravenously upon delivery of the anterior shoulder of the fetus. The first @entity0 received 20    g, and the dose for the subsequent @entity0 was determined according to the response of the previous @entity0 as per the biased-coin allocation scheme using increments or decrements of 20    g (maximum 140    g). Uterine tone was assessed by the obstetrician and rated as satisfactory or unsatisfactory throughout the intraoperative period. The primary outcome was satisfactory uterine tone with no need for additional uterotonic drugs intraoperatively. Secondary outcomes included use of additional uterotonic drugs postoperatively in the first 24  hr, estimated @entity1 , and adverse effects. RESULTS: The ED90 of @entity8 to produce adequate uterine tone was estimated at 121    g (95% confidence interval [CI]: 111 to 130; 99% CI: 108 to 133) using the truncated @entity7 ( @entity7 ) method. The isotonic estimator of ED90 was 140    g; however, the observed response rate across all doses was  <  90%. Also, the 95% CI of the @entity7 estimator is likely to have lower than expected coverage, while the 99% CI may have about 90% coverage. Therefore, these results should be interpreted with caution. The overall median (range) estimated @entity1 was 1,014 (104-2,436)  mL. The overall incidence of @entity3 and @entity4 were 45% and 57.5%, respectively. At a dose of 140    g, the incidence of @entity4 and intraoperative @entity5 was 76% and 14%, respectively. CONCLUSION: The ED90 of @entity8 at CD for @entity6 , as determined in our study, should be interpreted with caution since it may be underestimated. This dose is higher than the currently recommended dose of 100    g at elective CD and should not be used routinely given the uncertainty regarding its efficacy and the high incidence of @entity5 at higher doses. This trial was registered at ClinicalTrials.gov, number: NCT01725243.

title: @entity8 at Cesarean delivery for XXXX : a sequential allocation trial to determine the effective dose.

answer: @entity6


abstract: UNASSIGNED: Long-term potentiation induced by conditioning electrical stimulation of afferent fibers is a widely studied form of synaptic plasticity in the brain and the spinal cord. In the spinal cord dorsal horn, long-term potentiation is induced by a series of high-frequency trains applied to primary afferent fibers. Conditioning stimulation (CS) of sciatic nerve primary afferent fibers also induces expression of immediate early gene proteins in the lumbar spinal cord. However, the time course of immediate early gene expression and the rostral-caudal distribution of expression in the spinal cord have not been systematically studied. Here, we examined the effects of sciatic nerve conditioning stimulation (10 stimulus trains, 0.5 ms stimuli, 7.2 mA, 100 Hz, train duration 2 s, 8 s intervals between trains) on cellular expression of immediate early genes, @entity1 and @entity2 , in anesthetized @entity0 . Immunohistochemical analysis was performed on sagittal sections obtained from Th13- L5 segments of the spinal cord at 1, 2, 3, 6 and 12 h post-CS. Strikingly, all immediate early genes exhibited a monophasic increase in expression with peak increases detected in dorsal horn neurons at 2 hours post-CS. Regional analysis showed peak increases at the location between the L3 and L4 spinal segments. Both Arc, @entity1 and @entity2 remained significantly elevated at 2 hours, followed by a sharp decrease in immediate early gene expression between 2 and 3 hours post-CS. Colocalization analysis performed at 2 hours post-CS showed that all @entity1 and @entity2 neurons were positive for Arc, while 30% and 43% of Arc positive neurons were positive for @entity1 and @entity2 , respectively. The present study identifies the spinal cord level and time course of immediate early gene (IEGP) expression of relevance for analysis of IEGPs function in neuronal plasticity and nociception.

title: Time Course of Immediate Early Gene Protein Expression in the Spinal Cord following Conditioning Stimulation of the Sciatic Nerve in XXXX .

answer: @entity0


abstract: BACKGROUND: @entity0 following solid organ transplantation have an increased risk of developing de novo @entity2 , but their biology is poorly characterized. METHODS: We studied 1743 @entity0 who underwent a transurethral resection of a newly diagnosed @entity2 at a single institution. The histopathology, treatment, recurrence-free survival and overall survival were evaluated and compared between transplant and non-transplant @entity0 . RESULTS: We identified 74 transplant @entity0 who developed a de novo @entity2 after a median post-transplantation interval of 62  months. The @entity1 was malignant in 29 @entity0 (39  %). The most common benign lesion was @entity4 (84  %), which neither coexisted with nor developed into @entity1 during follow-up. Compared with non-transplant @entity0 (n  =  1669), transplant @entity0 were significantly younger (median 55 vs 69  years, P  <  0.001) and had a 9.0-fold higher odds of @entity1 (P  <  0.001), while there were no differences in pathology among @entity0 with @entity3 of the bladder (UCB). In a multivariable analysis for non-muscle-invasive UCB that was adjusted for the risk group, @entity0 with a transplant had a 1.8-fold increased risk of recurrence (P  =  0.048). Four of five transplant @entity0 did not respond to Bacillus Calmette-Gu  rin instillations. There were no differences in overall survival after radical cystectomy (P  =  0.87). CONCLUSIONS: The majority of @entity2 in transplant @entity0 are benign, and they neither coexist with nor develop into @entity1 . Transplant @entity0 with non-muscle-invasive UCB show an increased risk of disease recurrence, while those treated with radical cystectomy have similar outcomes to @entity0 without a transplant.

title: Histopathology and prognosis of de novo XXXX following solid organ transplantation.

answer: @entity2


abstract: BACKGROUND: Clinical studies have shown that @entity3 ( @entity3 ) are related to common @entity0 . It is unknown how often common @entity0 occur in subjects who have explained physical symptoms (PHY), @entity3 or both, in the general population, what the incidence rates are, and whether there is a difference between PHY and @entity3 in this respect. AIM: To study the prevalence and incidence rates of mood, @entity1 and substance use disorders in groups with PHY, @entity3 and combined @entity3 and PHY compared to a no-symptoms reference group in the general population. METHOD: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a nationally representative face-to-face survey of the general population aged 18-64 years. We selected subjects with explained physical symptoms only (n=1952), with @entity3 only (n=177), with both @entity3 and PHY (n=209), and a reference group with no physical symptoms (n=4168). The assessment of common @entity0 was through the Composite International Diagnostic Interview 3.0. Multivariate logistic regression analyses were used to examine the association between group membership and the prevalence and first-incidence rates of comorbid @entity0 , adjusted for socio-demographic characteristics. RESULTS: @entity3 were associated with the highest prevalence rates of mood and @entity1 , and combined @entity3 and PHY with the highest prevalence rates of @entity2 . Combined @entity3 and PHY were associated with a higher incidence rate of @entity4 only (OR 2.9 (95%CI:1.27,6.74)). CONCLUSION: In the general population, PHY, @entity3 and the combination of both are related to mood and @entity1 , but odds are highest for combined @entity3 and PHY in relation to substance use disorder. Combined @entity3 and PHY are related to a greater incidence of @entity4 . These findings warrant further research into possibilities to improve recognition and early intervention in subjects with combined @entity3 and PHY.

title: Medically Unexplained and Explained Physical Symptoms in the General Population: Association with Prevalent and Incident XXXX .

answer: @entity0


abstract: BACKGROUND: There is a clinical need for therapeutic options to reduce hyperinflation associated with severe @entity1 . Endobronchial Coils (coils) are @entity2 devices implanted bronchoscopically under fluoroscopic guidance to re-tension the lung. We report the medium term effectiveness and safety of coils in a study of @entity0 with @entity1 . METHODS: Forty five subjects with severe airflow obstruction and hyperinflation received bilateral sequential treatment with coils (30 day interval between treatments) as part of a randomised controlled trial with a primary endpoint 90 days after the final treatment (Clinicaltrials.gov NCT01334307). Further assessments were made at 180 and 360 days and in this study the primary outcome was the effect of coil treatment on the St. George's Respiratory Questionnaire (SGRQ) 360 days following treatment. RESULTS: At 360 days following treatment, there was an improvement in the SGRQ score of -6.1  14.0 points (p = 0.01) compared to baseline. Improvements in secondary outcomes were seen with increases in forced expiratory volume in the first second of 8.9   22.2% (p = 0.002) and 6-minute walking distance of 34.1  52.4m (p = 0.003). The safety profile was acceptable out to 360 days post-treatment. CONCLUSIONS: Statistically and clinically meaningful benefits in quality of life, exercise capacity and pulmonary function in @entity0 treated with coils are sustained twelve months after treatment. TRIAL REGISTRATION INFORMATION: Clinicaltrials.gov NCT01334307.

title: Endobronchial Coils for Severe XXXX Are Effective Up to 12 Months following Treatment: Medium Term and Cross-Over Results from a Randomised Controlled Trial.

answer: @entity1


abstract: Autopsy records at Mayo Clinic were reviewed to determine the pattern of @entity4 occurring as a consequence of nonmyxomatous @entity1 emboli. Between 1951 and 1984, there were seven adult @entity0 who fulfilled the criteria: focal or multifocal neurologic disease of abrupt onset; systemic @entity1 ; and pathologic demonstration of @entity1 emboli in appropriate vessels. Tumors originated from the lung in four @entity0 and from the colon and hypopharynx in one each; in one @entity0 the primary source was unknown. Five @entity0 had carotid and two had vertebrobasilar system @entity3 . Two @entity0 had at least one antecedent @entity2 ( @entity2 ). Three @entity0 presented with @entity4 as the initial manifestation of their @entity1 . In two @entity0 , it occurred immediately after pneumonectomy. In four @entity0 , @entity4 occurred in a setting of widespread systemic, including pulmonary, metastases. At postmortem examination, one @entity0 had a single large basilar @entity1 embolus. The others had @entity5 . The anterior circulation was affected in three @entity0 , the posterior circulation in two, and both circulations were affected in two. Four @entity0 had additional brain parenchymal metastases including one with diffuse leptomeningeal spread.

title: XXXX as a result of @entity1 emboli.

answer: @entity4


abstract: Autopsy records at Mayo Clinic were reviewed to determine the pattern of @entity4 occurring as a consequence of nonmyxomatous @entity1 emboli. Between 1951 and 1984, there were seven adult @entity0 who fulfilled the criteria: focal or multifocal neurologic disease of abrupt onset; systemic @entity1 ; and pathologic demonstration of @entity1 emboli in appropriate vessels. Tumors originated from the lung in four @entity0 and from the colon and hypopharynx in one each; in one @entity0 the primary source was unknown. Five @entity0 had carotid and two had vertebrobasilar system @entity3 . Two @entity0 had at least one antecedent @entity2 ( @entity2 ). Three @entity0 presented with @entity4 as the initial manifestation of their @entity1 . In two @entity0 , it occurred immediately after pneumonectomy. In four @entity0 , @entity4 occurred in a setting of widespread systemic, including pulmonary, metastases. At postmortem examination, one @entity0 had a single large basilar @entity1 embolus. The others had @entity5 . The anterior circulation was affected in three @entity0 , the posterior circulation in two, and both circulations were affected in two. Four @entity0 had additional brain parenchymal metastases including one with diffuse leptomeningeal spread.

title: @entity4 as a result of XXXX emboli.

answer: @entity1


abstract: Background @entity3 is a common surgical disease. Tension-free hernioplasty is currently commonly used for its treatment, with multiple advantages such as simple surgical method, low recurrence rate, and ability to be performed in primary care hospitals, but the risk of incision @entity4 still exists. Mild @entity4 can be cured by local washing, dressing, and systemic antibiotics. If the @entity4 is severe, the wound may not heal after removing the patch, and secondary suturing is needed. Material and Methods A total of 60 @entity0 with @entity1 after tension-free repair of @entity3 were randomly divided into control (n=30) and treatment (n=30) groups. @entity0 in the treatment group received Mesalt combined with Mepilex for dressing while the @entity0 in the control group received conventional gauze for dressing. @entity2 degree, wound healing time, and dressing times were observed. Results The clinical therapeutic effect in the treatment group was significantly better than in the control group. The treatment group exhibited significantly less @entity2 when @entity0 receive dressing, shorter wounds healing time (15  3.5 vs. 30  5.0), and less dressing frequency (10  2.1 vs. 20  2.4). Conclusions Mesalt combined with Mepilex can effectively improve @entity1 after @entity3 treatment, obviously reducing @entity2 , shorting wound healing time, and decreasing dressing frequency. It can be widely used in clinical practice.

title: Clinical curative effect of mesalt combined with mepilex dressing in @entity1 of XXXX .

answer: @entity3