abstract: AIM: This study evaluated the use of polymerase chain reaction for @entity4 diagnosis in clinical samples. MATERIALS AND METHODS: The sensitivity and specificity of the methodology were evaluated using eight @entity3 / @entity5 species complex reference strains and 165 cerebrospinal fluid samples from @entity0 with @entity1 divided into two groups: 96 @entity0 with @entity4 and @entity2 ; and 69 @entity0 with other @entity1 ( @entity6 / @entity2 ). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a specific product for @entity3 and another for @entity5 ). RESULTS: CN4-CN5 primer set was positive in all @entity3 standard strains and in 94.8% in DNA samples from @entity4 and @entity2 group. With the multiplex, no 448-bp product of @entity5 was observed in the clinical samples of either group. The 695bp products of @entity3 were observed only in 64.6% of the @entity4 and @entity2 group. This primer set was negative for two standard strains. The specificity based on the negative samples from the CTL/ @entity2 group was 98.5% in both primer sets. CONCLUSIONS: These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of @entity3 / @entity5 species complex in cerebrospinal fluid samples from @entity0 with clinical suspicion of @entity4 .

title: Molecular diagnosis of @entity4 in cerebrospinal fluid: comparison of primer sets for @entity3 and XXXX species complex.

answer: @entity5


abstract: AIM: This study evaluated the use of polymerase chain reaction for @entity4 diagnosis in clinical samples. MATERIALS AND METHODS: The sensitivity and specificity of the methodology were evaluated using eight @entity3 / @entity5 species complex reference strains and 165 cerebrospinal fluid samples from @entity0 with @entity1 divided into two groups: 96 @entity0 with @entity4 and @entity2 ; and 69 @entity0 with other @entity1 ( @entity6 / @entity2 ). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a specific product for @entity3 and another for @entity5 ). RESULTS: CN4-CN5 primer set was positive in all @entity3 standard strains and in 94.8% in DNA samples from @entity4 and @entity2 group. With the multiplex, no 448-bp product of @entity5 was observed in the clinical samples of either group. The 695bp products of @entity3 were observed only in 64.6% of the @entity4 and @entity2 group. This primer set was negative for two standard strains. The specificity based on the negative samples from the CTL/ @entity2 group was 98.5% in both primer sets. CONCLUSIONS: These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of @entity3 / @entity5 species complex in cerebrospinal fluid samples from @entity0 with clinical suspicion of @entity4 .

title: Molecular diagnosis of @entity4 in cerebrospinal fluid: comparison of primer sets for XXXX and @entity5 species complex.

answer: @entity3


abstract: AIM: This study evaluated the use of polymerase chain reaction for @entity4 diagnosis in clinical samples. MATERIALS AND METHODS: The sensitivity and specificity of the methodology were evaluated using eight @entity3 / @entity5 species complex reference strains and 165 cerebrospinal fluid samples from @entity0 with @entity1 divided into two groups: 96 @entity0 with @entity4 and @entity2 ; and 69 @entity0 with other @entity1 ( @entity6 / @entity2 ). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a specific product for @entity3 and another for @entity5 ). RESULTS: CN4-CN5 primer set was positive in all @entity3 standard strains and in 94.8% in DNA samples from @entity4 and @entity2 group. With the multiplex, no 448-bp product of @entity5 was observed in the clinical samples of either group. The 695bp products of @entity3 were observed only in 64.6% of the @entity4 and @entity2 group. This primer set was negative for two standard strains. The specificity based on the negative samples from the CTL/ @entity2 group was 98.5% in both primer sets. CONCLUSIONS: These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of @entity3 / @entity5 species complex in cerebrospinal fluid samples from @entity0 with clinical suspicion of @entity4 .

title: Molecular diagnosis of XXXX in cerebrospinal fluid: comparison of primer sets for @entity3 and @entity5 species complex.

answer: @entity4


abstract: Total @entity3 level was measured in 8,303 @entity0 and youth in Tokyo. Age ranged from 6 to 18 years. The change of total @entity3 level relates to sex and age, and @entity0 showed higher level than @entity0 . Not a small number of @entity0 revealed elevated total @entity3 level but some @entity0 showed very low level. HDL- @entity3 was determined and prevalence of @entity2 @entity4 risk factors was studied. The elevation of total @entity3 level in senior high school students was caused by either increase of HDL- @entity3 or increased total minus HDL- @entity3 fraction. High school @entity0 with @entity1 were found to have higher serum total @entity3 level accompanied by low HDL- @entity3 level. High school @entity0 of parents with @entity5 were found to have higher total @entity3 level. Majority of Japanese senior high school students were found to have one or more @entity4 risk factors. The necessity of prevention for @entity2 @entity4 starting from childhood in Japan is emphasized.

title: Risk factors of arteriosclerosis in Japanese XXXX .

answer: @entity0


abstract: Asynchronous flowering of @entity2 (canola) leads to seeds and siliques at varying stages of maturity as harvest approaches. This range of maturation can result in premature silique dehiscence (pod shattering), resulting in yield losses, which may be worsened by environmental stresses. Therefore, a goal for canola crop improvement is to reduce shattering in order to maximize yield. We performed a comprehensive transcriptome analysis on the dehiscence zone (DZ) and valve of @entity0 and Brassica siliques in shatter resistant and sensitive genotypes at several developmental stages. Among known @entity0 dehiscence genes, we confirmed that homologs of @entity7 , @entity5 , @entity8 , @entity9 and IND were associated with shattering in @entity4 and @entity2 . We noted a correlation between reduced pectin degradation genes and shatter-resistance. Tension between lignified and non-lignified cells in the silique DZ plays a major role in dehiscence. Light microscopy revealed a smaller non-lignified separation layer in relatively shatter-resistant @entity4 relative to @entity2 and this corresponded to increased expression of peroxidases involved in @entity6 polymerization. Sustained repression of auxin biosynthesis, transport and signaling in @entity4 relative to @entity2 may cause differences in dehiscence zone structure and cell wall constituents. Tension on the dehiscence zone is a consequence of shrinkage and loss of flexibility in the valves, which is caused by senescence and desiccation. Reduced shattering was generally associated with upregulation of ABA signaling and down-regulation of @entity1 and @entity3 signaling, corresponding to more pronounced stress responses and reduced senescence and photosynthesis. Overall, we identified 124 cell wall related genes and 103 transcription factors potentially involved in silique dehiscence.

title: A comprehensive transcriptome analysis of silique development and dehiscence in XXXX and Brassica integrating genotypic, interspecies and developmental comparisons.

answer: @entity0


abstract: BACKGROUND: Simultaneous saccharification and fermentation (SSF) is a promising process for bioconversion of lignocellulosic biomass. High glucan loading for hydrolysis and fermentation is an efficient approach to reduce the capital costs for bio-based products production. The SSF of steam-exploded @entity2 stover (SECS) for @entity1 production at high glucan loading and high temperature was investigated in this study. RESULTS: Glucan conversion of @entity2 stover biomass pretreated by steam explosion was maintained at approximately 71 to 79% at an enzyme loading of 30 filter paper units (FPU)/g glucan, and 74 to 82% at an enzyme loading of 60 FPU/g glucan, with glucan loading varying from 3 to 12%. Glucan conversion decreased obviously with glucan loading beyond 15%. The results indicated that the mixture was most efficient in enzymatic hydrolysis of SECS at 3 to 12% glucan loading. The optimal SSF conditions of SECS using a novel @entity0 were inoculation optical density (OD)600   =   4.0, initial pH  4.8, 50% nutrients added, 36  hours pre-hydrolysis time, 39  C, and 12% glucan loading (20% solid loading). With the addition of 2% @entity3 , glucan conversion, @entity1 yield, final @entity1 concentration reached 78.6%, 77.2%, and 59.8  g/L, respectively, under the optimal conditions. The results suggested that the solid and degradation products' inhibitory effect on the hydrolysis and fermentation of SECS were also not obvious at high glucan loading. Additionally, glucan conversion and final @entity1 concentration in SSF of SECS increased by 13.6% and 18.7%, respectively, compared with separate hydrolysis and fermentation (SHF). CONCLUSIONS: Our research suggested that high glucan loading (6 to 12% glucan loading) and high temperature (39  C) significantly improved the SSF performance of SECS using a thermal- and @entity1 -tolerant strain of @entity0 due to the removal of degradation products, sugar feedback, and solid's inhibitory effects. Furthermore, the surfactant addition obviously increased @entity1 yield in SSF process of SECS.

title: Simultaneous saccharification and fermentation of steam-exploded XXXX stover at high glucan loading and high temperature.

answer: @entity2


abstract: BACKGROUND: The MindSpot Clinic (MindSpot) provides remote screening assessments and therapist-guided treatment for @entity1 and @entity2 to adult Australians. Most @entity0 are self-referred. The purpose of this study was to report on the procedures followed to maintain the safety of @entity0 and to examine the circumstances of urgent referrals to local services made by this remote mental health service. METHOD: A description of the procedures used to manage risk, and an audit of case summaries of @entity0 who were urgently referred for crisis intervention. The reported measures were scores on self-report scales of @entity3 ( @entity5 ) and @entity2 (PHQ-9), the number reporting suicidal thoughts and plans, and the number of acute referrals. RESULTS: A total of 9061 @entity0 completed assessments and consented for analysis of their data in the year from 1 July, 2013 to 30 June, 2014. Of these, 2599 enrolled in online treatment at MindSpot, and the remainder were supported to access local mental health services. Suicidal thoughts were reported by 2366 (26.1  %) and suicidal plans were reported by 213 (2.4  %). There were 51 acute referrals, of whom 19 (37.3  %) lived in regional or remote locations. The main reason for referral was the @entity0 ' self-report of imminent suicidal intent. The police were notified in three cases, and in another case an ambulance attended after the @entity0 reported taking an @entity4 . For the remaining acute referrals, MindSpot therapists were able to identify a local mental health service or a general practitioner, confirm receipt of a written case summary, and confirm that the @entity0 had been contacted, or that the local service intended to contact the @entity0 . CONCLUSIONS: Around 0.6  % of the @entity0 seeking assessment or treatment by MindSpot were referred to local mental health services for urgent face to face care. The procedures for identifying and managing those @entity0 were satisfactory, and in every case, either emergency services or local mental health services were able to take over the @entity0 's care. This review suggests that the uncertainty associated with taking responsibility for the remote treatment of @entity0 who disclose active suicidal plans is not a major impediment to providing direct access online treatment for severe forms of @entity1 and @entity2 .

title: Procedures for risk management and a review of crisis referrals from the MindSpot Clinic, a national service for the remote assessment and treatment of XXXX and @entity2 .

answer: @entity1


abstract: BACKGROUND: The MindSpot Clinic (MindSpot) provides remote screening assessments and therapist-guided treatment for @entity1 and @entity2 to adult Australians. Most @entity0 are self-referred. The purpose of this study was to report on the procedures followed to maintain the safety of @entity0 and to examine the circumstances of urgent referrals to local services made by this remote mental health service. METHOD: A description of the procedures used to manage risk, and an audit of case summaries of @entity0 who were urgently referred for crisis intervention. The reported measures were scores on self-report scales of @entity3 ( @entity5 ) and @entity2 (PHQ-9), the number reporting suicidal thoughts and plans, and the number of acute referrals. RESULTS: A total of 9061 @entity0 completed assessments and consented for analysis of their data in the year from 1 July, 2013 to 30 June, 2014. Of these, 2599 enrolled in online treatment at MindSpot, and the remainder were supported to access local mental health services. Suicidal thoughts were reported by 2366 (26.1  %) and suicidal plans were reported by 213 (2.4  %). There were 51 acute referrals, of whom 19 (37.3  %) lived in regional or remote locations. The main reason for referral was the @entity0 ' self-report of imminent suicidal intent. The police were notified in three cases, and in another case an ambulance attended after the @entity0 reported taking an @entity4 . For the remaining acute referrals, MindSpot therapists were able to identify a local mental health service or a general practitioner, confirm receipt of a written case summary, and confirm that the @entity0 had been contacted, or that the local service intended to contact the @entity0 . CONCLUSIONS: Around 0.6  % of the @entity0 seeking assessment or treatment by MindSpot were referred to local mental health services for urgent face to face care. The procedures for identifying and managing those @entity0 were satisfactory, and in every case, either emergency services or local mental health services were able to take over the @entity0 's care. This review suggests that the uncertainty associated with taking responsibility for the remote treatment of @entity0 who disclose active suicidal plans is not a major impediment to providing direct access online treatment for severe forms of @entity1 and @entity2 .

title: Procedures for risk management and a review of crisis referrals from the MindSpot Clinic, a national service for the remote assessment and treatment of @entity1 and XXXX .

answer: @entity2


abstract: UNASSIGNED: TIDEL-II was designed to optimise outcomes for newly-diagnosed @entity1 ( @entity1 ) @entity0 . Two sequential cohorts enrolled a total of 210 @entity0 , all commencing @entity2 600 mg/day, with a planned dose escalation to 800mg/day for @entity0 with @entity2 plasma trough level <1000 ng/mL on day 22 (19%). @entity0 were then assessed with molecular treatment targets: BCR-ABL1  <=10%,  <=1% and  <=0.1% at 3, 6 and 12 months, respectively. Cohort I @entity0 who failed to achieve targets were escalated to @entity2 800 mg/day (if on 600mg/day), then subsequently switched to @entity3 400 mg BID for failing the same target 3 months later. Cohort II @entity0 who failed to achieve targets switched to @entity3 directly, as did @entity0 with intolerance or loss of response in either cohort. At 2 years, 55% of study @entity0 remained on @entity2 , and 30% were on @entity3 . Only 12% were >10% BCR-ABL1 at 3 months. Confirmed MMR was achieved in 64% and 73% at 12 and 24 months, respectively. MR(4.5) at 24 months was 34%. Overall and transformation-free survival was 96% and 95% at 3 years, respectively. This trial supports the feasibility and efficacy of an @entity2 -based approach with selective switching to @entity3 . Trial Registration #ACTRN12607000325404.

title: TIDEL-II: frontline use of @entity2 in CML with early switch to XXXX for failure to achieve time-dependent molecular targets.

answer: @entity3


abstract: UNASSIGNED: TIDEL-II was designed to optimise outcomes for newly-diagnosed @entity1 ( @entity1 ) @entity0 . Two sequential cohorts enrolled a total of 210 @entity0 , all commencing @entity2 600 mg/day, with a planned dose escalation to 800mg/day for @entity0 with @entity2 plasma trough level <1000 ng/mL on day 22 (19%). @entity0 were then assessed with molecular treatment targets: BCR-ABL1  <=10%,  <=1% and  <=0.1% at 3, 6 and 12 months, respectively. Cohort I @entity0 who failed to achieve targets were escalated to @entity2 800 mg/day (if on 600mg/day), then subsequently switched to @entity3 400 mg BID for failing the same target 3 months later. Cohort II @entity0 who failed to achieve targets switched to @entity3 directly, as did @entity0 with intolerance or loss of response in either cohort. At 2 years, 55% of study @entity0 remained on @entity2 , and 30% were on @entity3 . Only 12% were >10% BCR-ABL1 at 3 months. Confirmed MMR was achieved in 64% and 73% at 12 and 24 months, respectively. MR(4.5) at 24 months was 34%. Overall and transformation-free survival was 96% and 95% at 3 years, respectively. This trial supports the feasibility and efficacy of an @entity2 -based approach with selective switching to @entity3 . Trial Registration #ACTRN12607000325404.

title: TIDEL-II: frontline use of XXXX in CML with early switch to @entity3 for failure to achieve time-dependent molecular targets.

answer: @entity2


abstract: BACKGROUND: The conservative treatment of pediatric @entity1 can be socially and financially burdensome for @entity0 and families due to the long period of immobilization. New operative techniques have consistently gained significance in the treatment of such fractures due to a shorter period of immobilization. Elastic stable intramedullary nailing (ESIN) in particular has been proven to lead to better outcome in comparison to conservative treatment. This article presents the first study that compares the outcome of three versus two ESINs in the treatment of pediatric femoral shaft fractures. MATERIAL AND METHODS: A retrospective analysis of all @entity0 who underwent operative treatment of @entity1 with ESINs in our hospital from 2009-2012 was carried out. A follow-up examination was performed in mid-2013 by standardized evaluation of @entity2 and the movement capacity of the hip and knee joint. RESULTS: The follow-up examination revealed a @entity2 of the injured leg when three ESINs were used (p   =   0.013) and an impairment of the movement capacity in the hip joint of the injured leg (p   =   0.029). In addition the surgery time for metal removal of three ESINs was higher (p   =   0.046). All other evaluated parameters did not show any differences. CONCLUSION: In this study population the treatment of pediatric femoral shaft fractures with three ESINs showed no benefit in comparison to two ESINs and therefore should not be used to treat @entity1 . The @entity2 using three ESINs may be explained by a nonsymmetrical distribution of support points leading to an increased micromovement of the bone with increased callus formation.

title: [Therapy of pediatric XXXX : Two versus three elastic stable intramedullary nails.]

answer: @entity1


abstract: UNASSIGNED: In this study, the proximate and @entity1 compositions of the muscle tissue of 186 samples of fish belonging to fifteen species of freshwater fish harvested in subalpine lakes ( @entity11 , shad, @entity13 , whitefish, @entity5 , pike, black bullhead, @entity14 , perch, Italian roach, roach, rudd, @entity12 , chub and @entity10 ) were investigated. Most of the fish demonstrated a lipid content in the fillet lower than 2.0  g 100  g(-1) wet weight (range 0.6-9.7). A strong relationship between feeding behavior and @entity1 composition of the muscle lipids was observed. Planktivorous fish showed the lowest amounts of n-3 @entity2 (p  <  0.05), but the highest @entity7 ( @entity7 ) contents, in particular 18:1n-9. Conversely, carnivorous fish showed the highest amounts of @entity2 and @entity8 (p  <  0.05), but the lowest @entity7 contents. Omnivorous fish showed substantial proportions of n-3 @entity2 and the highest contents of @entity9 . Principal component analysis showed a distinct separation between fish species according to their feeding habits and demonstrated that the most contributing trophic markers were 18:1n-9, 18:3n-3, 22:6n-3 and 20:4n-6. The quantitative amounts n-3 @entity4 in muscle tissues varied depending on the fish species, the lipid content and the feeding habits. Some species were very lean, and therefore would be poor choices for @entity0 consumption to meet dietary n-3 fatty acid requirements. Nevertheless, the more frequently consumed and appreciated fish, shad and whitefish, had @entity6 and @entity3 contents in the range 900-1,000  mg 100  g(-1) fresh fillet.

title: XXXX Composition of Freshwater Wild Fish in Subalpine Lakes: A Comparative Study.

answer: @entity1


abstract: UNASSIGNED: Applications of @entity5 ( @entity5 ) are rapidly expanding and encompass molecular and cellular biology. @entity5 aids in the analysis of in vivo global molecular alterations, identifying potential biomarkers which may improve diagnosis and treatment of various pathologies. @entity5 has added new dimensionality to medical research. Pioneering gynecologists now study molecular mechanisms underlying female reproductive pathology with @entity5 -based tools. Although @entity6 including @entity1 , @entity2 , @entity3 , and @entity4 ( @entity4 ) carry low mortality rates, they cause significant physical, mental, and social detriments. Additionally, some benign disorders are unfortunately associated with @entity0 . @entity5 -based technology can detect malignant changes in formerly benign proteomes and metabolomes with distinct advantages of speed, sensitivity, and specificity. We present the use of @entity5 in proteomics and metabolomics, and summarize the current understanding of the molecular pathways concerning female reproductive anatomy. Highlight discoveries of novel protein and metabolite biomarkers via @entity5 -based technology, we underscore the clinical application of these techniques in the diagnosis and management of @entity6 .    2015 Wiley Periodicals, Inc. Mass Spec Rev 9999: XX-XX, 2015.

title: A mass spectrometric insight into the origins of XXXX .

answer: @entity6


abstract: PURPOSE: This study addressed whether age is prognostic for @entity3 ( @entity3 ) or @entity3 ( @entity3 ) in @entity0 with metastatic @entity1 (mCRC). @entity0 AND METHODS: A total of 20,023 @entity0 from 24 first-line clinical trials in the ARCAD (Aide et Recherche en Canc  rologie Digestive) database were analyzed. Primary age effects and interactions with age,sex, performance status (PS), and metastatic site were modeled using Cox proportional hazards stratified by treatment arm within study. RESULTS: Of total @entity0 , 3,051 (15%) were age < or =50 years. Age was prognostic for both @entity3 (P < .001)and @entity3 (P < .001), with U-shaped risk (i.e., highest risk was evident in youngest and oldest @entity0 ). Relative to @entity0 of middle age, the youngest @entity0 experienced 19% (95% CI, 7% to 33%) increased risk of @entity2 and 22% (95% CI, 10% to 35%) increased risk of progression. The oldest @entity0 experienced 42% (95% CI, 31% to 54%) increased risk of @entity2 and 15% (95% CI, 7% to 24%) increased risk of progression or @entity2 . This relationship was more pronounced in the first year of follow-up. Age remained marginally significant for @entity3 (P = .08) when adjusted forPS, sex, and presence of liver, lung, or peritoneal metastases, and age was significant in an adjusted model for @entity3 (P = .005). The age effect did not differ by site of metastatic disease, year of enrollment, type of therapy received, or biomarker mutational status. CONCLUSION: Younger and older age are associated with poorer @entity3 and @entity3 among treated @entity0 with mCRC. Younger and older @entity0 may represent higher-risk populations, and additional studies are warranted.

title: Association of age with survival in @entity0 with metastatic XXXX : analysis from the ARCAD Clinical Trials Program.

answer: @entity1


abstract: PURPOSE: This study addressed whether age is prognostic for @entity3 ( @entity3 ) or @entity3 ( @entity3 ) in @entity0 with metastatic @entity1 (mCRC). @entity0 AND METHODS: A total of 20,023 @entity0 from 24 first-line clinical trials in the ARCAD (Aide et Recherche en Canc  rologie Digestive) database were analyzed. Primary age effects and interactions with age,sex, performance status (PS), and metastatic site were modeled using Cox proportional hazards stratified by treatment arm within study. RESULTS: Of total @entity0 , 3,051 (15%) were age < or =50 years. Age was prognostic for both @entity3 (P < .001)and @entity3 (P < .001), with U-shaped risk (i.e., highest risk was evident in youngest and oldest @entity0 ). Relative to @entity0 of middle age, the youngest @entity0 experienced 19% (95% CI, 7% to 33%) increased risk of @entity2 and 22% (95% CI, 10% to 35%) increased risk of progression. The oldest @entity0 experienced 42% (95% CI, 31% to 54%) increased risk of @entity2 and 15% (95% CI, 7% to 24%) increased risk of progression or @entity2 . This relationship was more pronounced in the first year of follow-up. Age remained marginally significant for @entity3 (P = .08) when adjusted forPS, sex, and presence of liver, lung, or peritoneal metastases, and age was significant in an adjusted model for @entity3 (P = .005). The age effect did not differ by site of metastatic disease, year of enrollment, type of therapy received, or biomarker mutational status. CONCLUSION: Younger and older age are associated with poorer @entity3 and @entity3 among treated @entity0 with mCRC. Younger and older @entity0 may represent higher-risk populations, and additional studies are warranted.

title: Association of age with survival in XXXX with metastatic @entity1 : analysis from the ARCAD Clinical Trials Program.

answer: @entity0


abstract: INTRODUCTION: To date, no study has compared laparoscopy (LB) to percutaneous (PB) biopsy for the diagnosis of @entity1 . The objective of this study is to compare the success rate and safety profile of laparoscopic lymph node biopsy to the percutaneous approach in @entity0 with intra-abdominal lymphadenopathy concerning for @entity1 . MATERIALS AND METHODS: We performed a multi-institution, retrospective review of @entity0 undergoing lymph node biopsy for suspected @entity1 between 2005 and 2013. Our primary outcome was adequate tissue yield between the two techniques, both for histologic diagnosis and for ancillary studies such as flow cytometry. Secondary outcomes included 30-day morbidity, 30-day readmission rates, the need for additional lymph node biopsy procedures, and length of stay. RESULTS: All 34 of the LB @entity0 had adequate specimen for histologic diagnosis compared to 92.3  % of @entity0 with a PB (p  =  0.18). Significantly more @entity0 in the LB group had sufficient tissue for ancillary studies when needed than in the PB group, 95.5 and 68.2  %, respectively (p  =  0.04). A second biopsy was pursued in 23.1  % of failed PB @entity0 , 0  % with success on second attempt. DISCUSSION: When index of suspicion is high or when biopsy is performed for @entity0 previously diagnosed with @entity1 and recurrence/transformation is suspected, LB safely and consistently provides adequate tissue for initial diagnosis and for ancillary studies. In contrast, image-guided PB may be more appropriate for @entity0 for whom ancillary studies are unlikely to add to planned treatments or when there is a high risk of complications from either general anesthesia or @entity0 comorbidities.

title: Laparoscopy has a superior diagnostic yield than percutaneous image-guided biopsy for suspected XXXX .

answer: @entity1


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity6 ( @entity6 ) and @entity5 ( @entity5 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity0 with admission age<three days and ICD-9 diagnostic classification of @entity5 or @entity6 or procedural coding for @entity6 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity3 (major and minor), and chromosomal, other @entity4 , and @entity1 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity0 at high, intermediate, and low risk of @entity2 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity2 . The model can be summarized as follows with @entity0 first assigned a score for associated abnormalities: @entity7 =6 points, major @entity3 =3 points, @entity1 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity0 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for @entity5 ( @entity5 ) and XXXX ( @entity6 ).

answer: @entity6


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity6 ( @entity6 ) and @entity5 ( @entity5 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity0 with admission age<three days and ICD-9 diagnostic classification of @entity5 or @entity6 or procedural coding for @entity6 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity3 (major and minor), and chromosomal, other @entity4 , and @entity1 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity0 at high, intermediate, and low risk of @entity2 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity2 . The model can be summarized as follows with @entity0 first assigned a score for associated abnormalities: @entity7 =6 points, major @entity3 =3 points, @entity1 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity0 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for @entity5 ( @entity5 ) and @entity6 ( XXXX ).

answer: @entity6


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity6 ( @entity6 ) and @entity5 ( @entity5 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity0 with admission age<three days and ICD-9 diagnostic classification of @entity5 or @entity6 or procedural coding for @entity6 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity3 (major and minor), and chromosomal, other @entity4 , and @entity1 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity0 at high, intermediate, and low risk of @entity2 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity2 . The model can be summarized as follows with @entity0 first assigned a score for associated abnormalities: @entity7 =6 points, major @entity3 =3 points, @entity1 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity0 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for XXXX ( @entity5 ) and @entity6 ( @entity6 ).

answer: @entity5


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity6 ( @entity6 ) and @entity5 ( @entity5 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity0 with admission age<three days and ICD-9 diagnostic classification of @entity5 or @entity6 or procedural coding for @entity6 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity3 (major and minor), and chromosomal, other @entity4 , and @entity1 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity0 at high, intermediate, and low risk of @entity2 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity2 . The model can be summarized as follows with @entity0 first assigned a score for associated abnormalities: @entity7 =6 points, major @entity3 =3 points, @entity1 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity0 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for @entity5 ( XXXX ) and @entity6 ( @entity6 ).

answer: @entity5


abstract: UNASSIGNED: Introduction: Cervical vertebral (C) @entity5 is rarely reported in large breed @entity4 . @entity9 ( @entity9 ) may result from defects of @entity6 , failure of formation or both. This report describes two cases of C3-C4 @entity9 in young sighthounds, treated surgically. Case description: An 18-month-old female Deerhound and a six-week-old female Borzoi @entity4 were presented because of the complaints of reluctance to exercise and signs of of @entity10 . Both @entity4 were neurologically normal. Diagnostic imaging revealed @entity1 , moderate @entity7 , and spinal canal stenosis associated with chronic spinal cord pressure @entity3 . Both @entity4 underwent surgical treatment. Results: A staged two-step surgery starting with dorsal decompression was elected in the Deerhound. After the first surgical procedure, the @entity4 developed focal myelomalacia and @entity8 and was euthanatized. A ventral distraction-fusion technique with two locking plates was performed in the Borzoi. This @entity0 recovered uneventfully and long-term follow-up computed tomography revealed complete spondylodesis. Clinical significance: Until now, @entity9 has only been described in sighthounds. @entity9 might be considered a differential diagnosis in these breeds that are presented with signs of @entity2 . Ventral realignment-fusion and bone grafting may be considered for surgical treatment, although the earliest age at which this procedure can and should be performed remains unclear.

title: XXXX in two young sighthounds.

answer: @entity9


abstract: BACKGROUND: This study examined the prevalence and treatment of 17 co-occurring physical health conditions among adults with serious @entity3 , and factors associated with prevalence of the 5 most common medical co-morbidities. METHODS: Data were collected from 457 adults attending publicly funded mental health programs who participated in community health screenings held in 4 U.S. states. Face-to-face interviews included standardized items from the National Health Interview Survey and the National Health and Nutrition Examination Survey. Ordinary least squares regression analysis examined associations between prevalence of the 5 most common co-morbid conditions and respondents' demographic, clinical, attitudinal, and health insurance statuses. RESULTS: Compared to the U.S. population, prevalence was significantly higher for 14 out of 17 medical conditions assessed. The 5 most common were @entity5 (45%), @entity2 (44%), @entity6 (28%), @entity7 (22%), and @entity1 (21%). Controlling for age, study site, and Medicaid status, racial/ethnic minorities were almost twice as likely as Caucasians to be diagnosed with @entity2 and @entity1 ; @entity0 were almost twice as likely as @entity0 to be diagnosed with @entity1 ; and @entity0 with @entity4 were around half as likely as those with other disorders to be diagnosed with @entity2 and @entity7 . Age was positively related to all conditions except @entity6 . Treatment prevalence was below 70% for approximately half of ongoing conditions. CONCLUSIONS: These results suggest a high level of medical vulnerability and need for coordination of health and mental health services in this population. Associations with age, minority status, and gender point to the need for targeted health care strategies.

title: Factors associated with co-occurring medical conditions among adults with serious XXXX .

answer: @entity3


abstract: @entity6 ( @entity6 ) are widely used in @entity0 and adolescents to treat a variety of @entity2 . However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent @entity1 with @entity10 (OLA; a widely prescribed AAPD) on postnatal days 28-49, under dosing conditions that approximate those employed therapeutically in @entity0 , causes long-term behavioral and neurobiological perturbations. We have begun to study the mechanisms of these effects. @entity9 (DA) and @entity7 (5HT) regulate many neurodevelopmental processes. Currently approved @entity6 exert their therapeutic effects principally through their DAergic activities, although in @entity3 ( @entity3 ) and some other diseases for which @entity6 are prescribed, @entity5 is accompanied by @entity8 (GLUergic) and y-aminobutyric acidergic (GABAergic) transmission. Here, we use proton magnetic resonance spectroscopy ((1)H MRS) to investigate the effects of adolescent OLA administration on @entity11 and @entity4 levels. We found that the treatment caused long-term reductions in the levels of both @entity4 and @entity11 in the nucleus accumbens (NAc) of adult @entity1 treated with OLA during adolescence. The NAc is a key node in the brain's "reward" system, whose function is also disrupted in @entity3 . Further research into potential, OLA-induced changes in the levels of @entity4 and @entity11 in the NAc and other brain areas, and the dynamics and mechanisms of those changes, are an essential step for devising new adjunct therapies for existing @entity6 and for designing new drugs that increase therapeutic effects and reduce long-term abnormalities when administered to pediatric @entity0 .

title: XXXX antipsychotic treatment of adolescent @entity1 causes long term changes in glutamate and @entity11 levels in the nucleus accumbens.

answer: @entity10


abstract: @entity6 ( @entity6 ) are widely used in @entity0 and adolescents to treat a variety of @entity2 . However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent @entity1 with @entity10 (OLA; a widely prescribed AAPD) on postnatal days 28-49, under dosing conditions that approximate those employed therapeutically in @entity0 , causes long-term behavioral and neurobiological perturbations. We have begun to study the mechanisms of these effects. @entity9 (DA) and @entity7 (5HT) regulate many neurodevelopmental processes. Currently approved @entity6 exert their therapeutic effects principally through their DAergic activities, although in @entity3 ( @entity3 ) and some other diseases for which @entity6 are prescribed, @entity5 is accompanied by @entity8 (GLUergic) and y-aminobutyric acidergic (GABAergic) transmission. Here, we use proton magnetic resonance spectroscopy ((1)H MRS) to investigate the effects of adolescent OLA administration on @entity11 and @entity4 levels. We found that the treatment caused long-term reductions in the levels of both @entity4 and @entity11 in the nucleus accumbens (NAc) of adult @entity1 treated with OLA during adolescence. The NAc is a key node in the brain's "reward" system, whose function is also disrupted in @entity3 . Further research into potential, OLA-induced changes in the levels of @entity4 and @entity11 in the NAc and other brain areas, and the dynamics and mechanisms of those changes, are an essential step for devising new adjunct therapies for existing @entity6 and for designing new drugs that increase therapeutic effects and reduce long-term abnormalities when administered to pediatric @entity0 .

title: @entity10 antipsychotic treatment of adolescent @entity1 causes long term changes in glutamate and XXXX levels in the nucleus accumbens.

answer: @entity11


abstract: @entity6 ( @entity6 ) are widely used in @entity0 and adolescents to treat a variety of @entity2 . However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent @entity1 with @entity10 (OLA; a widely prescribed AAPD) on postnatal days 28-49, under dosing conditions that approximate those employed therapeutically in @entity0 , causes long-term behavioral and neurobiological perturbations. We have begun to study the mechanisms of these effects. @entity9 (DA) and @entity7 (5HT) regulate many neurodevelopmental processes. Currently approved @entity6 exert their therapeutic effects principally through their DAergic activities, although in @entity3 ( @entity3 ) and some other diseases for which @entity6 are prescribed, @entity5 is accompanied by @entity8 (GLUergic) and y-aminobutyric acidergic (GABAergic) transmission. Here, we use proton magnetic resonance spectroscopy ((1)H MRS) to investigate the effects of adolescent OLA administration on @entity11 and @entity4 levels. We found that the treatment caused long-term reductions in the levels of both @entity4 and @entity11 in the nucleus accumbens (NAc) of adult @entity1 treated with OLA during adolescence. The NAc is a key node in the brain's "reward" system, whose function is also disrupted in @entity3 . Further research into potential, OLA-induced changes in the levels of @entity4 and @entity11 in the NAc and other brain areas, and the dynamics and mechanisms of those changes, are an essential step for devising new adjunct therapies for existing @entity6 and for designing new drugs that increase therapeutic effects and reduce long-term abnormalities when administered to pediatric @entity0 .

title: @entity10 antipsychotic treatment of adolescent XXXX causes long term changes in glutamate and @entity11 levels in the nucleus accumbens.

answer: @entity1


abstract: BACKGROUND: @entity6 ( @entity6 ) is a transactivator of transcription of @entity0 c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very low background. @entity6 is abundantly expressed in the majority of @entity2 and has been implicated in @entity1 development. Although it down-regulates the expression of proapoptotic @entity4 protein, it is not known whether @entity6 also interacts and antagonizes the function of @entity1 suppressor protein @entity3 . METHODS: Western blotting was carried out to detect the expression level of @entity6 , @entity4 and @entity3 , and also @entity3 regulatory factors, @entity7 and @entity5 ; real-time quantitative PCR was done to determine the fold change in mRNA levels of target proteins; immunoprecipitation was carried out to determine the interaction of @entity6 with @entity3 , @entity7 and @entity5 . Cells stably knockdown for either @entity6 ; @entity3 or @entity7 were examined for @entity3 reporter activity under normal and radiation-induced stress. RESULTS: @entity6 physically interacted with @entity3 , impairing its transcription activity and reducing @entity3 -mediated sensitivity to cellular stress. Knockdown of @entity6 expression activated @entity3 -mediated response to cellular stress while transient expression of @entity6 in @entity6 -knockdown cells restored the inhibition of @entity3 activity. @entity6 not only interacted with both @entity7 and @entity5 , which, respectively, function as positive and negative regulators of @entity3 , but also regulated their expression under cellular stress. In @entity6 knockdown cells, @entity5 expression was down-regulated under radiation-induced stress whereas expression of @entity7 and @entity4 were significantly up-regulated suggesting @entity6 as a potential regulator of these proteins. We hypothesize that the @entity6 -mediated suppression of @entity3 activity may occur via preventing the interaction of @entity3 with @entity7 as well as by @entity6 -mediated regulation of @entity3 regulatory proteins, @entity5 and @entity7 . Since @entity6 suppresses @entity3 activity and is overexpressed in most @entity1 , it may have a possible role in tumorigenesis. CONCLUSION: @entity6 physically interacts with @entity3 , functions as a regulator of @entity3 -regulatory proteins ( @entity5 and @entity7 ), and suppresses @entity3 transactivation activity under radiation-induced cellular stress. Since it is abundantly expressed in most @entity1 , it may have implication in tumorigenesis and thus may be a possible target for drug development.

title: Fuse binding protein antagonizes the transcription activity of @entity1 suppressor protein XXXX .

answer: @entity3


abstract: BACKGROUND: @entity6 ( @entity6 ) is a transactivator of transcription of @entity0 c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very low background. @entity6 is abundantly expressed in the majority of @entity2 and has been implicated in @entity1 development. Although it down-regulates the expression of proapoptotic @entity4 protein, it is not known whether @entity6 also interacts and antagonizes the function of @entity1 suppressor protein @entity3 . METHODS: Western blotting was carried out to detect the expression level of @entity6 , @entity4 and @entity3 , and also @entity3 regulatory factors, @entity7 and @entity5 ; real-time quantitative PCR was done to determine the fold change in mRNA levels of target proteins; immunoprecipitation was carried out to determine the interaction of @entity6 with @entity3 , @entity7 and @entity5 . Cells stably knockdown for either @entity6 ; @entity3 or @entity7 were examined for @entity3 reporter activity under normal and radiation-induced stress. RESULTS: @entity6 physically interacted with @entity3 , impairing its transcription activity and reducing @entity3 -mediated sensitivity to cellular stress. Knockdown of @entity6 expression activated @entity3 -mediated response to cellular stress while transient expression of @entity6 in @entity6 -knockdown cells restored the inhibition of @entity3 activity. @entity6 not only interacted with both @entity7 and @entity5 , which, respectively, function as positive and negative regulators of @entity3 , but also regulated their expression under cellular stress. In @entity6 knockdown cells, @entity5 expression was down-regulated under radiation-induced stress whereas expression of @entity7 and @entity4 were significantly up-regulated suggesting @entity6 as a potential regulator of these proteins. We hypothesize that the @entity6 -mediated suppression of @entity3 activity may occur via preventing the interaction of @entity3 with @entity7 as well as by @entity6 -mediated regulation of @entity3 regulatory proteins, @entity5 and @entity7 . Since @entity6 suppresses @entity3 activity and is overexpressed in most @entity1 , it may have a possible role in tumorigenesis. CONCLUSION: @entity6 physically interacts with @entity3 , functions as a regulator of @entity3 -regulatory proteins ( @entity5 and @entity7 ), and suppresses @entity3 transactivation activity under radiation-induced cellular stress. Since it is abundantly expressed in most @entity1 , it may have implication in tumorigenesis and thus may be a possible target for drug development.

title: Fuse binding protein antagonizes the transcription activity of XXXX suppressor protein @entity3 .

answer: @entity1


abstract: @entity1 is prevalent worldwide, and is highly associated with @entity2 , such as insulin resistance, @entity3 and @entity4 . @entity7 has been used as food and traditional herbal medicine for the treatment of various @entity2 . However, the molecular mechanisms how @entity7 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity9 ( @entity5 ), a major @entity7 constituent, inhibited @entity6 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity1 (DIO) @entity0 , @entity5 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity4 , in the livers. These effects were confirmed with genetically @entity1 ob/ob @entity0 . A reporter gene assay showed that @entity5 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity5 was specifically bound to PPARy @entity8 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity5 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity1 and @entity4 . Our findings shed new light on the mechanism of @entity7 in the treatment of @entity2 .

title: XXXX , a novel PPARy antagonist from @entity7 , alleviates @entity4 in @entity0 .

answer: @entity9


abstract: @entity1 is prevalent worldwide, and is highly associated with @entity2 , such as insulin resistance, @entity3 and @entity4 . @entity7 has been used as food and traditional herbal medicine for the treatment of various @entity2 . However, the molecular mechanisms how @entity7 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity9 ( @entity5 ), a major @entity7 constituent, inhibited @entity6 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity1 (DIO) @entity0 , @entity5 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity4 , in the livers. These effects were confirmed with genetically @entity1 ob/ob @entity0 . A reporter gene assay showed that @entity5 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity5 was specifically bound to PPARy @entity8 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity5 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity1 and @entity4 . Our findings shed new light on the mechanism of @entity7 in the treatment of @entity2 .

title: @entity9 , a novel PPARy antagonist from @entity7 , alleviates XXXX in @entity0 .

answer: @entity4


abstract: @entity1 is prevalent worldwide, and is highly associated with @entity2 , such as insulin resistance, @entity3 and @entity4 . @entity7 has been used as food and traditional herbal medicine for the treatment of various @entity2 . However, the molecular mechanisms how @entity7 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity9 ( @entity5 ), a major @entity7 constituent, inhibited @entity6 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity1 (DIO) @entity0 , @entity5 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity4 , in the livers. These effects were confirmed with genetically @entity1 ob/ob @entity0 . A reporter gene assay showed that @entity5 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity5 was specifically bound to PPARy @entity8 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity5 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity1 and @entity4 . Our findings shed new light on the mechanism of @entity7 in the treatment of @entity2 .

title: @entity9 , a novel PPARy antagonist from XXXX , alleviates @entity4 in @entity0 .

answer: @entity7


abstract: @entity1 is prevalent worldwide, and is highly associated with @entity2 , such as insulin resistance, @entity3 and @entity4 . @entity7 has been used as food and traditional herbal medicine for the treatment of various @entity2 . However, the molecular mechanisms how @entity7 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity9 ( @entity5 ), a major @entity7 constituent, inhibited @entity6 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity1 (DIO) @entity0 , @entity5 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity4 , in the livers. These effects were confirmed with genetically @entity1 ob/ob @entity0 . A reporter gene assay showed that @entity5 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity5 was specifically bound to PPARy @entity8 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity5 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity1 and @entity4 . Our findings shed new light on the mechanism of @entity7 in the treatment of @entity2 .

title: @entity9 , a novel PPARy antagonist from @entity7 , alleviates @entity4 in XXXX .

answer: @entity0


abstract: OBJECTIVE: In European countries more than 50% of the population are overweight, 30% with @entity2 . In Poland overweight was present in 41% of @entity0 and 28.7% of @entity0 ( @entity2 15.7% and 19.9%). It was examined whether @entity2 affects serum levels of @entity11 ( @entity11 ) and @entity8 ( @entity8 ), which may lead to the consequences of @entity2 , such as type 2 @entity1 , @entity3 , and finally the @entity5 . We aimed to examine whether @entity2 affects the serum levels of @entity11 and @entity8 . @entity0 AND METHODS: The study involved 144 @entity0 aged 45 to 86 years, 80 subjects with diagnosed @entity2 and 64 with normal body weight,  <= 65 years old (n = 45) and > 65 years old (n = 99). All @entity0 underwent tests of @entity7 , total @entity4 , HDL, LDL, @entity10 levels, using routine laboratory methods. A test of the concentration of @entity8 and @entity11 was carried out. The declared level of physical activity (gymnastics, cycling or walking) was considered. RESULTS: It was shown that in @entity0  <= 65 years old, @entity2 was associated with higher levels of @entity8 . When the test group, divided into the above categories, was analyzed for the diagnosis of @entity3 , @entity9 or @entity1 , no statistically significant differences in the investigated parameters were detected. The concentration of @entity11 did not differ in the investigated subjects, regardless of sex, age, @entity2 , or the declared physical activity. CONCLUSIONS: The concentration of @entity8 in younger @entity0 , including those with normal body weight, correlated with total @entity4 and @entity6 levels, and it was significantly higher in @entity2 @entity0 compared to those with normal body weight.

title: Obesity itself does not influence XXXX serum levels in adults.

answer: @entity11


abstract: There have been significant changes in @entity2 ( @entity2 ) in @entity0 in the last decade. These changes relate to epidemiology and clinical presentation. Resistance to antibiotics is also a changing issue. These all have to be considered when treating @entity2 . In this document, two of the main Spanish pediatric societies involved in the treatment of @entity2 in @entity0 , propose a consensus concerning therapeutic approach. These societies are the Spanish Society of @entity1 and the Spanish Society of Paediatric @entity3 . The Advisory Committee on Vaccines of the Spanish Association of Paediatrics ( @entity4 -AEP) has also been involved in the prevention of @entity2 . An attempt is made to provide up-to-date guidelines to all paediatricians. The first part of the statement presents the approach to ambulatory, previously healthy @entity0 . We also review the prevention with currently available vaccines. In a next second part, special situations and complicated forms will be addressed.

title: [Community acquired pneumonia in XXXX : Outpatient treatment and prevention.]

answer: @entity0


abstract: Genes and the environment both influence the metabolic processes that determine fitness. To illustrate the importance of metabolism for @entity0 brain evolution and health, we use the example of lipid energy metabolism, i.e. the use of fat (lipid) to produce energy and the advantages that this metabolic pathway provides for the brain during environmental energy shortage. We briefly describe some features of metabolism in ancestral organisms, which provided a molecular toolkit for later development. In modern @entity0 , lipid energy metabolism is a regulated multi-organ pathway that links @entity2 in fat tissue to the mitochondria of many tissues including the brain. Three important control points are each suppressed by insulin. (1) Lipid reserves in adipose tissue are released by lipolysis during fasting and stress, producing @entity3 (FAs) which circulate in the blood and are taken up by cells. (2) FA oxidation. Mitochondrial entry is controlled by @entity6 ( @entity6 ). Inside the mitochondria, FAs undergo beta oxidation and energy production in the Krebs cycle and respiratory chain. (3) In liver mitochondria, the @entity4 ( @entity4 ) pathway produces @entity5 bodies for the brain and other organs. Unlike most tissues, the brain does not capture and metabolize circulating FAs for energy production. However, the brain can use @entity5 bodies for energy. We discuss two examples of genetic metabolic traits that may be advantageous under most conditions but deleterious in others. (1) A @entity6 variant prevalent in Inuit @entity0 may allow increased FA oxidation under nonfasting conditions but also predispose to hypoglycemic episodes. (2) The thrifty genotype theory, which holds that energy expenditure is efficient so as to maximize energy stores, predicts that these adaptations may enhance survival in periods of famine but predispose to @entity1 in modern dietary environments.

title: Metabolism as a tool for understanding XXXX brain evolution: Lipid energy metabolism as an example.

answer: @entity0


abstract: OBJECTIVE: To investigate the pathology characteristics of @entity5 with @entity3 , in order to reduce the recurrence rate after surgery and improve operative technique. METHOD: Twenty-five @entity0 diagnosed as @entity5 with @entity3 were analyzed. There were 14 @entity0 in @entity3 history group, 9 in infective stage group, and 2 in recurrence group respectively. The whole piece of @entity4 and scar tissue was completely excised during operation. The specimens were observed by naked eye and serial tissue sections were analyzed. RESULT: (1) Macroscopically, in @entity3 history group, initial morphology can be maintained near the @entity4 orifice, but the distal tissue was dark red scar tissue. In infective stage group, the distal tissue of the specimens was granulation tissue and cicatricial tissue. The granulation tissue was crisp and bright red. In recurrence group, @entity2 with severe @entity1 was observed, with a classical dumb-bell appearence. (2) Microscopically, in @entity3 history group and recurrence group, we can see that the distal @entity4 tissue was discontinuous and was separated by scar tissue. In infective stage group, we can find neo-angiogenesis and infiltration of plasma cells, lymphocytes, neutrophil between interrupted @entity4 tissues. (3) All @entity0 were followed up for 6-12 month, without recurrence. CONCLUSION: The @entity4 tissue of @entity5 with @entity3 was divided by the scar tissue, and they did not communicate with each other. Complete delineation of @entity4 is hardly achieved by @entity6 staining. Radical excision of the @entity4 and scar tissue may help to avoid leaving viable squamous epithelial remnants and reduce the recurrence rate.

title: [ XXXX : a histopathology observation].

answer: @entity5


abstract: INTRODUCTION: Dual supraorbital and occipital nerve stimulation (SONS and ONS) have shown promising efficacy in treating @entity1 . However, its functional outcome is not well studied. We report functional outcome of combined SONS and ONS for @entity3 using verified metrics. METHODS: Consecutive @entity0 who have both supraorbital and occipital nerve stimulators and also underwent @entity3 Disability Assessment (MIDAS) and Beck Depression Index (BDI) both pre- and postoperatively were studied. Outcome variables included net improvement of ranked MIDAS and BDI scores. Predictor variables included @entity0 with 50% improvement of @entity2 , disability status, number of years from diagnosis to implantation, and narcotic use. Multivariate analysis of variance (MANOVA) was performed to assess the correlation between the outcome and predictor variables. RESULTS: Sixteen @entity0 (12 female; age average 51.8 years) were studied. Follow-up ranged from 5 to 80 months (average 44.5    21.4 months). Eight had a positive response (50% improvement in @entity1 ) at most recent follow-up. Fifty percent improvement in @entity1 was the only predictor of outcome variables combined (total MIDAS, MIDAS-B, and BDI) (P = .021). Of note, this improvement in functional outcome was only significant during the perioperative period and not throughout the length of follow-up. No other predictive factors were significantly correlated with the functional outcomes. Among the predictor variables, a strong correlation was found for disability status being inversely related to reporting 50% improvement in @entity1 (r = -0.582). CONCLUSION: In @entity0 who had positive response to SONS and ONS, functional status as reflected by MIDAS and BDI had overall improvement in perioperative period. Unfortunately, this effect waned over the long-term follow-up.

title: 185   Long-term Follow-up in Functional Outcomes of Combined Supraorbital Nerve Stimulation and Occipital Nerve Stimulation for Chronic Headache XXXX .

answer: @entity0


abstract: INTRODUCTION: Better ways to predict motor outcome following hemispherectomy are necessary to implement the informed consent process in @entity0 with @entity2 . The volumetric analysis of cerebral peduncles and cerebellar hemispheres in @entity0 who had undergone hemispherectomy may determine prognostic implications for @entity1 . METHODS: Twenty-two @entity0 who underwent hemispherectomy at our institution, who had follow-up of at least 6 months and had accessible preoperative volumetric MRIs were retrospectively included. With the use of iPlan/BrainLAB imaging software, the volumes of bilateral cerebral peduncles and cerebellar hemispheres were calculated. After defining the borders of region of interest the volume of the resulting enclosed figure was calculated using software iPlan cranial via a semiautomatic voxel-based segmentation method. RESULTS: Eleven @entity0 were found to have improved or unchanged @entity3 (group 1); these were compared with 11 who had worsening @entity3 following hemispherectomy (group 2). The ratio of ipsilateral/contralateral peduncle volume in group 1 was 0.535 with a standard deviation of 0.23 (laterality refers to side of hemispherectomy), significantly lower than the ratio in group 2 (0.79 with a standard deviation of 0.21; P value <.0139). No @entity0 with a peduncle ratio of less than 0.5 experienced worsening of @entity3 . CONCLUSION: While @entity0 who undergo hemispherectomy are heterogeneous, we report a method of predicting @entity1 only using a standard volumetric MRI. This information could be used in the preoperative discussions with @entity0 and families to help better understand that chance of retaining baseline motor function.

title: 194   Volumetric Analysis of Cerebral Peduncles and Cerebellar Hemispheres for Predicting XXXX Following Hemispherectomy.

answer: @entity3


abstract: The use of "Energy Drinks" ( @entity0 ) is increasing in India. Students specially use these drinks to rejuvenate after strenuous exercises or as a stimulant during exam times. The most common ingredient in EDs is @entity2 and a popular @entity0 available and commonly used is Red Bull, containing 80 mg of @entity2 in 250 ml bottle. The primary aim of this study was to investigate the effects of Red Bull energy drink on Auditory reaction time and @entity1 . A homogeneous group containing twenty medical students (10 males, 10 females) participated in a crossover study in which they were randomized to supplement with Red Bull (2 mg/kg body weight of @entity2 ) or isoenergetic isovolumetric noncaffeinated control drink (a combination of Appy Fizz, Cranberry juice and soda) separated by 7 days. @entity1 ( @entity1 ) was recorded as the highest of the 3 values of maximal isometric force generated from the dominant hand using hand grip dynamometer (Biopac systems). Auditory reaction time (ART) was the average of 10 values of the time interval between the click sound and response by pressing the push button using hand held switch (Biopac systems). The energy and control drinks after one hour of consumption significantly reduced the Auditory reaction time in males ( @entity0 232    59 Vs 204    34 s and Control 223    57 Vs 210    51 s; p < 0.05) as well as in females ( @entity0 227    56 Vs 214    48 s and Control 224    45 Vs 215    36 s; p < 0.05) but had no effect on @entity1 in either sex (males @entity0 381    37 Vs 371    36 and Control 375    61 Vs 363    36 Newton, females @entity0 227    23 Vs 227    32 and Control 234    46 Vs 228    37 Newton). When compared across the gender groups, there was no significant difference between males and females in the effects of any of the drinks on the ART but there was an overall significantly lower @entity1 in females compared to males. Both energy drink and the control drink significantly improve the reaction time but may not have any effect on muscular performance. Energy drink per se is no better than control drink, which may indicate that there is no role of @entity2 in the beneficial effect seen after the drinks.

title: Effect of red bull energy drink on auditory reaction time and maximal XXXX .

answer: @entity1


abstract: The present paper aims to investigate whether or not @entity3 ( @entity3 ) exists in @entity2 ( @entity2 ), and to elucidate its relationship to microvessel density (MVD), @entity4 ( @entity4 ) expressionb and clinicopathological factors of @entity0 with @entity2 . @entity3 , score of MVD and expression of @entity4 protein were detected by immunohistochemistry and histochemistry in 83 specimens of @entity2 tissue and 20 specimens of nor- mal laryngeal tissue. The positive rate of @entity3 in normal laryngeal tissues was 0%, and was 33.7% in @entity2 tissues. There was a significant difference between the two groups (P<0. 01). @entity3 or MVD was significantly related to differentiation, pTNM stages and lymph node metastasis of @entity2 (P<0.05), but not to age, gender and @entity1 site (P>0. 05). And there was a positive correlation between every two of @entity3 , score of MVD, and @entity4 protein (P< 0. 05). The results suggest that expression of @entity4 protein may be related to the initiation, angiogenesis and @entity3 formation in @entity2 ; And @entity3 , angiogenesis and @entity4 protein may be involved in the development, invasion and metastasis of @entity2 .

title: [Vasculogenic mimicry in XXXX and its clinicopathological significance].

answer: @entity2


abstract: BACKGROUND: An objective assessment of quadriceps strength after anterior cruciate ligament reconstruction (ACLR) is an important clinical measure to determine readiness to @entity2 ( @entity2 ). Not all clinicians are equipped with the means to objectively quantify quadriceps strength limb symmetry indices (Q-LSIs) via lower extremity isokinetic dynamometers, as recommended by previous studies. PURPOSE/HYPOTHESIS: The purpose of this study was to determine whether the International Knee Documentation Committee 2000 Subjective Knee Form (IKDC) score at time of @entity2 was a predictor of quadriceps strength in a young, athletic population after ACLR. Two hypotheses were tested: (1) Individuals with higher self-reports of function would demonstrate better quadriceps strength of the involved limb than individuals with lower self-reports of function at the time of @entity2 , and (2) individuals with higher self-reports of function would have normal quadriceps strength limb symmetry. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2. METHODS: At time of @entity2 , 139 subjects who had undergone ACLR completed the IKDC. In addition, an isometric quadriceps strength test (Biodex dynamometer) was performed on both lower extremities. Peak torques were calculated, as was the Q-LSI, determined by the formula (involved limb peak torque/uninvolved limb peak torque) * 100%. @entity0 were dichotomized based on IKDC scores: high IKDC (IKDC >= 90) and low IKDC (IKDC <90). Two-way analysis of variance was used to determine the effect of limb (involved vs uninvolved) and group (high vs low IKDC) on isometric quadriceps strength. Chi-square and logistic regression analyses were then performed to determine whether IKDC scores could predict Q-LSI. RESULTS: At time of @entity2 , a significant correlation between IKDC scores and (1) peak isometric torque (r = 0.282, P < .001) and (2) Q-LSI (r = 0.357, P < .001) was observed. Individuals with IKDC scores >= 90 were 3 times (OR = 3.4; 95% CI, 1.71-6.93) more likely to demonstrate higher Q-LSI (>= 90%). An IKDC score >= 94.8 predicted Q-LSI >= 90% with high sensitivity (0.813) and moderate specificity (0.493). CONCLUSION: @entity0 with higher IKDC scores demonstrated an increased likelihood of presenting with greater involved limb quadriceps strength and better Q-LSI. Based on the results of this study, a @entity0 -reported outcome measure, such as the IKDC, may be able to serve as a valuable screening tool for the identification of @entity1 in this population; however, it should not be considered an accurate surrogate for isokinetic dynamometry. Furthermore, a score of >= 94.8 on the IKDC is likely to indicate that a @entity0 's quadriceps strength is at an acceptable @entity2 level.

title: The Influence of Quadriceps Strength Asymmetry on XXXX -Reported Function at Time of Return to Sport After Anterior Cruciate Ligament Reconstruction.

answer: @entity0


abstract: OBJECTIVE: To observe the effects of daily consumption of milk powder on Healthy young @entity0 , including the effect on menstrual cycles, ovulation time and sex hormone concentrations in morning urine. METHOD: Thirty-two young @entity0 were recruited as subjects and randomly assigned into two groups for a milk powder consumption experiment which lasted three menstrual cycles. The first menstrual cycle is control cycle, the second menstrual cycle is milk-taking cycle. The subjects take milk diluted by 33g or 55g milk powder each day, from the 4th to the 24th day of the second menstrual cycle. The third menstrual cycles is control cycle after milk-taking. During the whole three menstrual cycle, record the length of each menstrual cycle, determine ovulation time by using basal body temperature and oviposit test paper, collect their morning urine samples at specified times (the 4th, 7th, 10th, 13rd, 16th, 19th and 24th day of first and the third menstrual cycle; the 4th, 5th, 6th, 7th, 9th, 12nd, 15th, 18th, 21st and 24th day of the second menstrual cycle), determine the concentrations of @entity1 , @entity3 and @entity2 in morning urine samples; draw the curve of the concentration changing over time and calculate the area under the curve to the 24th day. RESULT: In the high-dose group, the mean of the menstrual cycle length are (29.60   3.180) d, (28.87    3.021) d, (29.60    2.995) d, the mean of the ovulation time are (15.47    2.200) d. There was no significant difference in menstrual cycle length and ovulation time among cycles and between groups (P>0.05). Calculate the difference between the first and the second menstrual cycle, and the difference between the two groups. In the high-dose group, the area under the curve of @entity1 concentrations adjusted by @entity2 are (7160.28   2305.52), (6700.26   2066.67); (6676.24   2573.89); the area under the curve of @entity3 concentrations corrected by @entity2 are (51.93   18.80), (44.55   14.62) and (46.49   22.44). In the low-dose group, the area under the curve of @entity1 concentrations adjusted by @entity2 are (6838.21   2573.89), (6611.33   1648.21) and (5949.24   1437.54)/ The area under the curve of @entity3 concentrations adjusted by @entity2 are (49.25   15.68), (48.79   15.61) and (43.45   12.77). There   s no significant difference of the area under the curve among three menstrual cycles and between two groups (P>0.05). CONCLUSION: 21 days    continuous daily consumption of milk powder does not have a significant impact on menstrual cycle, or on the @entity1 / @entity3 concentrations in morning urine.

title: [Effects of daily consumption of milk powder on menstrual cycles and urine sex hormone concentrations of young XXXX ].

answer: @entity0


abstract: BACKGROUND: A transient endothelial hyperpermeability is a hallmark of severe @entity1 . @entity2 ( @entity3 ) maintains vascular integrity and protects against plasma leakage. We related plasma @entity3 levels to dengue-induced plasma leakage and studied mechanisms that may underlie the decrease in @entity3 levels in dengue. METHODS: We determined circulating levels of @entity3 in 44 Indonesian adults with acute dengue and related levels to plasma leakage, as determined by daily ultrasonography, and to levels of its chaperone apolipoprotein M, other lipoproteins and platelets. RESULTS: Plasma @entity3 levels were decreased during dengue and @entity0 with plasma leakage had lower median levels compared to those without (638 vs. 745  nM; p  <  0.01). @entity4 and other lipoprotein levels were also decreased during dengue, but did not correlate to @entity3 levels. Platelet counts correlated positively with @entity3 levels, but @entity3 levels were not higher in frozen-thawed platelet rich plasma, arguing against platelets as an important cellular source of @entity3 in dengue. CONCLUSIONS: Decreased plasma @entity3 levels during dengue are associated with plasma leakage. We speculate that decreased levels of @entity4 underlies the lower @entity3 levels. Modulation of @entity3 levels and its receptors may be a novel therapeutic intervention to prevent plasma leakage in dengue.

title: Decreased plasma levels of the endothelial protective XXXX are associated with dengue-induced plasma leakage.

answer: @entity2


abstract: A 58-year-old @entity0 was transferred to us from his local hospital because of failure to control his @entity3 by endoscopic hemostasis. Abdominal imaging suggested a hypervascular @entity2 of the pancreatic head (36  mm diameter), and laboratory testing showed an elevated serum @entity9 level (17,800  pg/mL). Gastroduodenal endoscopy revealed @entity6 from the ampulla of Vater. The selective arterial secretagogue injection test suggested a @entity8 in the pancreatic head, but no @entity8 in the pancreatic tail. The @entity0 was diagnosed with solitary pancreatic head @entity8 complicated by hemosuccus pancreaticus, and pancreaticoduodenectomy was performed. Intraoperatively, the diagnosis was changed to primary @entity5 without pancreatic involvement. The @entity3 stopped postoperatively and serum @entity9 levels returned to normal. Histological examination of the surgical specimens revealed a small @entity8 in the duodenum (7  mm diameter). The final diagnosis was microgastrinoma of the duodenum with peripancreatic lymph node @entity1 . The cause of @entity4 from the ampulla of Vater was initially obscure, but eventually a @entity4 with moderate atypia was found in the common bile duct, indicating @entity2 ( @entity2 ). This is the first report of @entity7 due to @entity2 with @entity8 .

title: XXXX due to @entity2 associated with Zollinger-Ellison syndrome.

answer: @entity7


abstract: A 58-year-old @entity0 was transferred to us from his local hospital because of failure to control his @entity3 by endoscopic hemostasis. Abdominal imaging suggested a hypervascular @entity2 of the pancreatic head (36  mm diameter), and laboratory testing showed an elevated serum @entity9 level (17,800  pg/mL). Gastroduodenal endoscopy revealed @entity6 from the ampulla of Vater. The selective arterial secretagogue injection test suggested a @entity8 in the pancreatic head, but no @entity8 in the pancreatic tail. The @entity0 was diagnosed with solitary pancreatic head @entity8 complicated by hemosuccus pancreaticus, and pancreaticoduodenectomy was performed. Intraoperatively, the diagnosis was changed to primary @entity5 without pancreatic involvement. The @entity3 stopped postoperatively and serum @entity9 levels returned to normal. Histological examination of the surgical specimens revealed a small @entity8 in the duodenum (7  mm diameter). The final diagnosis was microgastrinoma of the duodenum with peripancreatic lymph node @entity1 . The cause of @entity4 from the ampulla of Vater was initially obscure, but eventually a @entity4 with moderate atypia was found in the common bile duct, indicating @entity2 ( @entity2 ). This is the first report of @entity7 due to @entity2 with @entity8 .

title: @entity7 due to XXXX associated with Zollinger-Ellison syndrome.

answer: @entity2


abstract: One of directions of the search of hormonal signaling systems regulators is the development of peptides that correspond to the cytoplasmic regions of @entity7 ( @entity7 ). Modification of the pepti- des with hydrophobic radicals increases their efficiency and selectivity. But currently is not studied as the acti- vity of the peptide depends on the localization of the hydrophobic radicals, their number and the chemical natu- re. The aim of this work was the synthesis of modified by @entity2 radicals derivatives of peptide 562-572 corresponding to the C-terminal region of @entity4 ( @entity4 ), and the study of regulatory ef- fects of the acylated @entity4 -peptides on the basal and hormone-stimulated activity of adenylyl cyclase (AC) in the @entity1 tissues. To elucidate the effect of localization of hydrophobic radicals and their number the modification of peptide 562-572 only at the N- or C-terminus or at both ends was carried out. To study the effect of hydrop- hobicity the residues ofpalmitic ( @entity5 ) and decanoic (Dec) acids were selected. Using a solid phase strategy we have synthesized unmodified peptide NDTKIAKK-Nle-A562-572-KA (1) and five of its acylated analogues, such as N[K(Dec)]DTKIAKK-Nle-A562-572-KA (2), NKDTKIAKK-Nle-A562-572-[K(Dec)]A (3), N[K(Dec)] DTKIAKK-Nle-A562-572-[K(Dec)]A (4), N[K( @entity5 )]DTKIAKK-Nle-A562-572-KA (5), and NKDTKIAKK-Nle- A562--572-[K( @entity5 )]A (6). Peptide 6 modified with @entity3 at the C-terminus to a large extent increased the ba- sal AC activity and reduced AC stimulating effect of @entity0 chorionic gonadotropin (hCG) in the testes of @entity1 , peptides 3 and 4 modified with @entity6 at the C-terminus were less effective, but exceeded in activity the un- modified peptide 1, while peptides 2 and 5 acylated at the N-terminus were little active. The action of peptides was characterized by the tissue and the receptor specificity. Thus, the modification of @entity4 -peptide 562-572 with @entity2 radicals at the C-terminus increases its regulatory effect on the functional activity of the adenyla- te cyclase system in the @entity1 testes, indicating promising the modification of @entity7 -peptides with hydrophobic radicals. These data support the hypothesis that the hydrophobic radical to be localized in the locus of @entity7 -peptide, where a transmembrane domain is located in the receptor.

title: [Regulation of adenylyl cyclase activity in the @entity1 testes by acylated derivatives of peptide 562-572 of XXXX ].

answer: @entity4


abstract: One of directions of the search of hormonal signaling systems regulators is the development of peptides that correspond to the cytoplasmic regions of @entity7 ( @entity7 ). Modification of the pepti- des with hydrophobic radicals increases their efficiency and selectivity. But currently is not studied as the acti- vity of the peptide depends on the localization of the hydrophobic radicals, their number and the chemical natu- re. The aim of this work was the synthesis of modified by @entity2 radicals derivatives of peptide 562-572 corresponding to the C-terminal region of @entity4 ( @entity4 ), and the study of regulatory ef- fects of the acylated @entity4 -peptides on the basal and hormone-stimulated activity of adenylyl cyclase (AC) in the @entity1 tissues. To elucidate the effect of localization of hydrophobic radicals and their number the modification of peptide 562-572 only at the N- or C-terminus or at both ends was carried out. To study the effect of hydrop- hobicity the residues ofpalmitic ( @entity5 ) and decanoic (Dec) acids were selected. Using a solid phase strategy we have synthesized unmodified peptide NDTKIAKK-Nle-A562-572-KA (1) and five of its acylated analogues, such as N[K(Dec)]DTKIAKK-Nle-A562-572-KA (2), NKDTKIAKK-Nle-A562-572-[K(Dec)]A (3), N[K(Dec)] DTKIAKK-Nle-A562-572-[K(Dec)]A (4), N[K( @entity5 )]DTKIAKK-Nle-A562-572-KA (5), and NKDTKIAKK-Nle- A562--572-[K( @entity5 )]A (6). Peptide 6 modified with @entity3 at the C-terminus to a large extent increased the ba- sal AC activity and reduced AC stimulating effect of @entity0 chorionic gonadotropin (hCG) in the testes of @entity1 , peptides 3 and 4 modified with @entity6 at the C-terminus were less effective, but exceeded in activity the un- modified peptide 1, while peptides 2 and 5 acylated at the N-terminus were little active. The action of peptides was characterized by the tissue and the receptor specificity. Thus, the modification of @entity4 -peptide 562-572 with @entity2 radicals at the C-terminus increases its regulatory effect on the functional activity of the adenyla- te cyclase system in the @entity1 testes, indicating promising the modification of @entity7 -peptides with hydrophobic radicals. These data support the hypothesis that the hydrophobic radical to be localized in the locus of @entity7 -peptide, where a transmembrane domain is located in the receptor.

title: [Regulation of adenylyl cyclase activity in the XXXX testes by acylated derivatives of peptide 562-572 of @entity4 ].

answer: @entity1


abstract: BACKGROUND AND AIMS: 99mTc-pertechnetate scintigraphy has long been used for detection of @entity1 ( @entity1 ) in the medical practice and evaluation of @entity0 with lower @entity2 . In the current study, we reviewed the available medical literature in this regard. METHODS: Medline and SCOPUS were searched for relevant studies. Studies with sample size of at least 5 @entity0 which provided enough numerical data to calculate the sensitivity and/or specificity of 99mTc-pertechnetate for detection of @entity1 were includ ed in the systematic review. RESULTS: Overall 40 studies were included in our systematic review. Overall diagnostic indices of the 99mTc-pertechnetate scintigraphy for @entity1 diagnosis were: sensitivity 92.1% [95% CI: 90.2-93.8], specificity 95.4% [943-963], positive likelihood ratio 16.5 [9.9-27.], negative likelihood ratio 0.15 [0.1-0.2], diagnostic odds ratio 120.7 [73-199]. The pooled sensitivity was higher for studies using H2 blockers as a premedication (92.4% vs. 86.4%), studies using delayed imaging (943% vs. 88.4%), @entity0 (92.3% vs. 81.8%), and @entity0 with @entity2 (953% vs. 75.3%). CONCLUSIONS: 99mTc-pertechnetate imaging is a highly accurate diagnostic modality for detection of @entity1 . This imaging is more accurate in @entity0 and @entity0 presenting with @entity2 . Premedication with H2 blockers and delayed imaging can increase the diagnostic accuracy and should be routinely included in the imaging protocol.

title: 99mTc-Pertechnetate imaging for detection of XXXX : a systematic review and meta-analysis of the pertinent literature..

answer: @entity1


abstract: OBJECTIVE: To explore the distribution characteristics of basic syndromes and its related factors in @entity0 with @entity5 ( @entity5 ). METHODS: The complete data of 538 @entity0 with @entity5 were collected and initial database was established with Epidata 3. 0. TCM syndrome typing was performed. The distribution characteristics of basic syndromes were analyzed using SPSS 17. 0 Software. The univariate and multivariate Logistic regression analyses were performed with SPSS 17. 0 Software to determine basic syndrome related factors such as age, engaged professionals, @entity1 , @entity4 , @entity8 , interpersonal relations, work fatigue, stimulating beverage, exercise conditions, Western medicine type of @entity9 , and so on. RESULTS: The TCM syndrome frequency of @entity5 @entity0 was sequenced from high to low as @entity6 (380 cases, 70.6%), qi stagnation syndrome (337 cases, 62.6%), blood @entity6 (234 cases, 43.5%), @entity11 (220 cases, 40.9%), @entity10 (197 cases, 36.6%), and others(58 cases, 10. 8%) . Most @entity0 were complicated with complex syndromes, and the most common complex syndromes were @entity7 complicated qi stagnation syndrome (275 cases, 51.1%) and @entity7 complicated blood @entity6 (222 cases, 41.3%). Aging, work fatigue, and exercise conditions were main related factors for @entity6 (P <0. 01, P <0. 05). Poor emotional ( @entity4 and @entity3 tendencies), @entity8 , interpersonal relations, @entity9 were main related factors for qi stagnation syndrome (P <0.01). Sleep quality and poor emotional ( @entity4 and @entity3 tendencies) were main related factors for blood @entity6 (P <0. 01, P < 0.05). Stimulating beverages were main related factor for @entity11 (P <0.05). Engaged in mental work and @entity2 were main related factors for @entity10 (P < 0. 01, P <0. 05). CONCLUSIONS: @entity5 is featured as complex syndromes. The most common complex syndromes were @entity7 complicated qi stagnation syndrome and @entity7 complicated blood @entity6 . Basic syndrome related factors such as age, engaged professionals, @entity1 , poor emotional ( @entity4 and @entity3 tendencies), @entity8 , interpersonal relations, work fatigue, stimulating beverage, exercise conditions, Western medicine type of @entity9 were associated with the distribution of @entity5 .

title: [Distribution characteristics of basic XXXX and its related factors analysis].

answer: @entity5


abstract: OBJECTIVE: To observe the effect of xuebijing Injection (XI) on perioperative @entity6 and inflammatory reaction in senile @entity0 receiving @entity3 ( @entity3 ). METHODS: Totally eighty @entity0 receiving @entity3 at Luoyang Orthopedics Hospital, 65 to 85 years old, were randomly assigned to the control group (40 cases) and the treatment group (40 cases). All @entity0 received routine perioperative therapies. Those in the treatment group received XI (adding 50 mL XI in 100 mL normal saline, 30 min each time). XI was continually injected after @entity3 , twice daily for 3 successive days. Blood samples were harvested on the morning of the 2nd admission day (TO), immediately after operation (T1), on the morning of the 3rd day after operation (T3), and on the morning of the 5th day after operation (T4) to detect prothrombin time (PT), @entity2 time (TT), activated partial thromboplastin time (APTT), levels of FIB and D-dimer (D-D), changes of white blood cell (WBC), neutrophils (N), @entity5 ( @entity5 ), erythrocyte sedimentation rate (ESR), and @entity4 . Complications of surgery were compared between the two groups. RESULTS: There was no statistical difference in operation time, intraoperative @entity1 , and blood transfusion between the two groups (P >0.05). Compared with TO in the same group, WBC, N, @entity5 , ESR, @entity4 , PT, TT, and D-D all increased in the control group at T1-T4 (P < 0.05); APTT increased at T1-T2 (P <0.05); FIB increased at T1-T3 (P <0.05). WBC, N, @entity4 , PT, and D-D all increased in the treatment group at T1-T3 (P <0.05); @entity5 and ESR increased at T1-T4 (P < 0.05); TT increased at T1-T2 (P <0.05); APTT and FIB increased at T1 (P <0.05). Compared with the control group at the same time period, WBC, N, @entity5 , and @entity4 all decreased in the treatment group at T1-T4 (P <0.05), ESR decreased at T3-T4 (P <0.05); PT and TT decreased at T1-T3 (P <0.05); FIB and D-D decreased at T2-T4 (P<0.05). The occurrence of each complication was significantly lower in the treatment groups than in the control group. CONCLUSION: XI could improve the perioperative high @entity6 state of senile @entity3 @entity0 , inhibit inflammatory reactions, and reduce complications.

title: [Effect of xuebijing injection on perioperative @entity6 function and inflammatory reaction in senile @entity0 receiving XXXX ].

answer: @entity3


abstract: OBJECTIVE: To observe the effect of xuebijing Injection (XI) on perioperative @entity6 and inflammatory reaction in senile @entity0 receiving @entity3 ( @entity3 ). METHODS: Totally eighty @entity0 receiving @entity3 at Luoyang Orthopedics Hospital, 65 to 85 years old, were randomly assigned to the control group (40 cases) and the treatment group (40 cases). All @entity0 received routine perioperative therapies. Those in the treatment group received XI (adding 50 mL XI in 100 mL normal saline, 30 min each time). XI was continually injected after @entity3 , twice daily for 3 successive days. Blood samples were harvested on the morning of the 2nd admission day (TO), immediately after operation (T1), on the morning of the 3rd day after operation (T3), and on the morning of the 5th day after operation (T4) to detect prothrombin time (PT), @entity2 time (TT), activated partial thromboplastin time (APTT), levels of FIB and D-dimer (D-D), changes of white blood cell (WBC), neutrophils (N), @entity5 ( @entity5 ), erythrocyte sedimentation rate (ESR), and @entity4 . Complications of surgery were compared between the two groups. RESULTS: There was no statistical difference in operation time, intraoperative @entity1 , and blood transfusion between the two groups (P >0.05). Compared with TO in the same group, WBC, N, @entity5 , ESR, @entity4 , PT, TT, and D-D all increased in the control group at T1-T4 (P < 0.05); APTT increased at T1-T2 (P <0.05); FIB increased at T1-T3 (P <0.05). WBC, N, @entity4 , PT, and D-D all increased in the treatment group at T1-T3 (P <0.05); @entity5 and ESR increased at T1-T4 (P < 0.05); TT increased at T1-T2 (P <0.05); APTT and FIB increased at T1 (P <0.05). Compared with the control group at the same time period, WBC, N, @entity5 , and @entity4 all decreased in the treatment group at T1-T4 (P <0.05), ESR decreased at T3-T4 (P <0.05); PT and TT decreased at T1-T3 (P <0.05); FIB and D-D decreased at T2-T4 (P<0.05). The occurrence of each complication was significantly lower in the treatment groups than in the control group. CONCLUSION: XI could improve the perioperative high @entity6 state of senile @entity3 @entity0 , inhibit inflammatory reactions, and reduce complications.

title: [Effect of xuebijing injection on perioperative XXXX function and inflammatory reaction in senile @entity0 receiving @entity3 ].

answer: @entity6


abstract: OBJECTIVE: To observe the effect of xuebijing Injection (XI) on perioperative @entity6 and inflammatory reaction in senile @entity0 receiving @entity3 ( @entity3 ). METHODS: Totally eighty @entity0 receiving @entity3 at Luoyang Orthopedics Hospital, 65 to 85 years old, were randomly assigned to the control group (40 cases) and the treatment group (40 cases). All @entity0 received routine perioperative therapies. Those in the treatment group received XI (adding 50 mL XI in 100 mL normal saline, 30 min each time). XI was continually injected after @entity3 , twice daily for 3 successive days. Blood samples were harvested on the morning of the 2nd admission day (TO), immediately after operation (T1), on the morning of the 3rd day after operation (T3), and on the morning of the 5th day after operation (T4) to detect prothrombin time (PT), @entity2 time (TT), activated partial thromboplastin time (APTT), levels of FIB and D-dimer (D-D), changes of white blood cell (WBC), neutrophils (N), @entity5 ( @entity5 ), erythrocyte sedimentation rate (ESR), and @entity4 . Complications of surgery were compared between the two groups. RESULTS: There was no statistical difference in operation time, intraoperative @entity1 , and blood transfusion between the two groups (P >0.05). Compared with TO in the same group, WBC, N, @entity5 , ESR, @entity4 , PT, TT, and D-D all increased in the control group at T1-T4 (P < 0.05); APTT increased at T1-T2 (P <0.05); FIB increased at T1-T3 (P <0.05). WBC, N, @entity4 , PT, and D-D all increased in the treatment group at T1-T3 (P <0.05); @entity5 and ESR increased at T1-T4 (P < 0.05); TT increased at T1-T2 (P <0.05); APTT and FIB increased at T1 (P <0.05). Compared with the control group at the same time period, WBC, N, @entity5 , and @entity4 all decreased in the treatment group at T1-T4 (P <0.05), ESR decreased at T3-T4 (P <0.05); PT and TT decreased at T1-T3 (P <0.05); FIB and D-D decreased at T2-T4 (P<0.05). The occurrence of each complication was significantly lower in the treatment groups than in the control group. CONCLUSION: XI could improve the perioperative high @entity6 state of senile @entity3 @entity0 , inhibit inflammatory reactions, and reduce complications.

title: [Effect of xuebijing injection on perioperative @entity6 function and inflammatory reaction in senile XXXX receiving @entity3 ].

answer: @entity0


abstract: OBJECTIVE: To explore different regulatory effects of electroacupuncture (EA) at the same acupoint on the heart and the stomach. METHODS: Eighty male SD @entity0 were randomly divided into eight groups equally, i.e., the Neiguan ( @entity1 ) group, the Quchi (LI11) group, the Tianshu (ST25) group, the Danzhong (RN17) group, the Zusanli (ST36) group, the Sanyinjiao ( @entity2 ) group, the Xinshu (BL15) group, and the Weishu (BL21) group, 10 in each group. The regulatory effects of EA (2/15 Hz, 3 mA, 2 min) at different acupoints on the gastric motility (intragastric pressure) and the cardiac function (the left ventricular pressure) were observed. The mean values of effect of two-min pre-EA and after-EA were compared. RESULTS: Compared with the pre-EA in the same group, the left ventricular pressure decreased in the Neiguan ( @entity1 ) group, the Quchi (LI11) group, the Danzhong (RN17) group, the Sanyinjiao ( @entity2 ) group, and the Xinshu (BL15) group (P <0.05). The intragastric pressure increased in the Quchi (LI11) group, the Zusanli (ST36) group, the Sanyinjiao ( @entity2 ) group, and the Xinshu (BL15) group, while it decreased in the Tianshu (ST25) group, the Danzhong (RN17) group, and the Weishu (BL21) group (P <0.05). The difference of the left ventricular pressure was sequenced from high to low as Xinshu (BL15) >Danzhong (RN17) >Neiguan ( @entity1 ) >Sanyinjiao ( @entity2 ) >Quchi (LI11). The difference of the intragastric pressure was sequenced from high to low as Tianshu (ST25) >Weishu (BL21) > Xinshu (BL15) > Danzhong (RN17) > Zusanli (ST36) > Sanyinjiao ( @entity2 ) > Quchi (LI11). CONCLUSIONS: EA at the same acupoint (2/15 Hz, 3 mA) showed different regulatory effects on the heart and stomach. There existed some difference in the direction and size due to the acupoint location, meridians, dominant nerve segment or relating organs. A fixed effect direction to the specific target was also shown.

title: [Regulatory effect of electroacupuncture on heart and stomach of XXXX ].

answer: @entity0