abstract: Neuroadapted @entity9 (NSV) was selected by serial passage of wild-type @entity9 (SV) in @entity0 brain. After intracerebral inoculation of weanling @entity0 , NSV causes a severe @entity6 with hindlimb @entity5 and high mortality; SV causes nonfatal mild disease. In order to determine the biologic basis of neurovirulence in vivo, these @entity7 have been compared by using infectivity assays, light and electron microscopy, in situ hybridization, immunohistochemistry, and double-labeling for neural cell markers and viral RNA. More infectious virus is present in the central nervous system during NSV than during SV @entity2 . After intracerebral inoculation, both @entity1 and spread to gray matter areas, including the ventral horns of the spinal cord. Their cellular targets are not different, and @entity3 is prominent. NSV infects more neurons, and causes more severe injury than SV. In @entity4 , there is marked swelling of lumbar and thoracic neurons and their processes in the ventral horns. Relatively mild changes are detected in SV @entity2 only by electron microscopy. Neuroadaptation likely occurs by increasing the efficiency of viral replication in neurons, rather than by a fundamental change in the cellular tropism or the topography of the @entity8 .

title: Basis of neurovirulence in @entity9 @entity6 of XXXX .

answer: @entity0


abstract: As a first step towards developing a DNA transformation method for the ciliated protozoan Euplotes crassus we determined the minimum inhibitory concentration (MIC) for cell division in the presence of @entity3 (Chx) for several cell lines and the range of Chx sensitivity for 106 different progeny cell lines derived by mating two lines. All of the cell lines are highly sensitive to Chx. Progeny cell lines show a wider range of sensitivities than the parental lines. Because site-directed mutagenesis of the RPL29 gene encoding the large subunit ribosomal protein 29 (L29) has been used to generate a Chx-resistance marker (ChxR) for another ciliate, @entity4 [Yao and Yao, Proc. Natl. Acad. Sci. USA 88 (1991) 9493-9497], we isolated and sequenced the entire @entity5 macronuclear DNA carrying RPL29. The encoded peptide is 52-73% identical in sequence to L29 sequences from organisms ranging from @entity4 and @entity1 to @entity0 . In @entity5 , the codon that has been mutated to confer Chx resistance in both @entity1 and @entity4 already encodes the @entity2 residue of one of the mutant forms identified in these other organisms. Thus, @entity5 RPL29 is not a convenient source of a selectable marker. Notable features of the macronuclear DNA carrying RPL29 are its extremely short non-coding regions and a TAG stop codon.

title: Sequence of the macronuclear DNA encoding large subunit ribosomal protein 29 (L29) in Euplotes crassus and XXXX sensitivity.

answer: @entity3


abstract: The @entity0 ribosomal protein rp51 is encoded by two interchangeable genes, @entity1 and @entity2 . We altered the RP51 gene dose by creating deletions of the @entity1 or @entity2 genes or both. Deletions of both genes led to spore inviability, indicating that rp51 is an essential ribosomal protein. From single deletion studies in haploid cells, we concluded that there was no intergenic dosage compensation at the level of mRNA abundance or mRNA utilization (translational efficiency), although phenotypic analysis had previously indicated a small compensation effect on growth rate. Similarly, deletions in diploid strains indicated that no strong mechanisms exist for intragenic dosage compensation; in all cases, a decreased dose of RP51 genes was characterized by a slow growth phenotype. A decreased dose of RP51 genes also led to insufficient amounts of 40S ribosomal subunits, as evidenced by a dramatic accumulation of excess 60S ribosomal subunits. We conclude that inhibition of 40S synthesis had little or no effect on the synthesis of the 60S subunit components. Addition of extra copies of rp51 genes led to extra rp51 protein synthesis. The additional rp51 protein was rapidly degraded. We propose that rp51 and perhaps many ribosomal proteins are normally oversynthesized, but the unassembled excess is degraded, and that the apparent compensation seen in haploids, i.e., the fact that the growth rate of mutant strains is less depressed than the actual reduction in mRNA, is a consequence of this excess which is spared from proteolysis under this circumstance.

title: Effect of RP51 gene dosage alterations on ribosome synthesis in XXXX .

answer: @entity0


abstract: Ten @entity1 strains were screened for @entity0 contamination using two differently designed @entity0 -specific polymerase chain reactions (PCR). The primers of the @entity0 -specific PCR designed by Spaepen et al. (9) cross-reacted with all of the @entity1 strains giving false-positive results. When the 10 strains of @entity1 were tested for mycoplasmas with the PCR designed by Harasawa et al. (5), only 3 were positive. Mycoplasmas were cultured from these three @entity1 strains confirming the latter PCR results. The PCR of Harasawa et al. (5) was highly specific for mycoplasmas and did not cross-react with @entity1 . These findings suggest that chlamydiae should be periodically screened for @entity0 contamination. Careful attention to primer design is important if PCR is chosen as the screening method.

title: XXXX contamination of chlamydiae isolated from clinical specimens.

answer: @entity0


abstract: 1. Responses of single units in area 29 of cingulate cortex were examined in alert @entity0 during vestibular and @entity3 . Eye movements were measured by optically detecting the position of an infrared light-emitting diode attached to the @entity2 . 2. Fourteen percent of cingulate cells (68 of 477 isolated units) had responses that were correlated to the occurrence of quick phases. Latencies ranged from 60 ms before to 220 ms after the onset of the quick phase with a mean of 70 ms and standard deviation of 58 ms. Most units responded during or following quick phases, although four units had responses that preceded the quick-phase onset. 3. Unitary responses during quick phases were not due to @entity1 , since these responses occurred in the dark as well as the light. The responses were not dependent upon vestibular stimulation, since responses related to @entity4 were observed in cingulate quick-phase neurons. 4. The majority (37 of 52) of the quick-phase neurons had a directional preference. Approximately equal numbers of directional units responded to quick phases directed ipsilaterally and contralaterally with respect to the recording site. 5. About one-fourth of the quick-phase units were bidirectional (15 of 52) with virtually equal responses to ipsilaterally and contralaterally directed quick phases. 6. Auditory and/or somatosensory responses were observed in only five of the quick-phase cells. All such multimodal units were bidirectional. 7. The quick-phase units were histologically confirmed to be primarily in area 29d of cingulate cortex. Although most cells were located in layer V, some were isolated in layer II-III. 8. Cingulate cortex has reciprocal connections with visual cortex and oculomotor-related thalamic nuclei and projects to the layers of the superior colliculus that are involved in oculomotor control. Responses to quick phases in cingulate neurons may synchronize cingulate cortex responsiveness with the arrival of new, and potentially significant, visual information.

title: Neuronal responses in XXXX cingulate cortex linked to quick-phase eye movements during nystagmus.

answer: @entity0


abstract: STUDY DESIGN: A retrospective case study was performed on the single-stage posterior transvertebral closing-wedge osteotomy for treatment of @entity6 . SUMMARY OF BACKGROUND DATA: Forty-one consecutive cases in 38 @entity0 available for follow-up, averaging 33 months (range 4-87 months), are included. All @entity0 had severe @entity8 ; 51% of cases had previous @entity4 , and 49% had postlaminectomy failed back syndromes with @entity6 . A preoperative @entity1 was present in 34% of the cases including two with @entity7 . METHODS: @entity0 examination and interviews, subjective questionnaire, chart reviews, and radiographic measurements were performed independently. Complications, risks, benefits, results, and biomechanical considerations were evaluated and discussed as compared with other techniques. RESULTS: All cases had solid union at follow-up; 93% maintained correction averaging 35 degrees with three requiring revision for failure. Postoperatively, 19.5% of the cases had new @entity1 with five (12.2%) temporary or minor and three (7.3%) major, including one with unimproved @entity5 at follow-up. Eight of the 14 preoperative @entity1 cases improved postoperatively; 26 additional surgeries were performed on 18 @entity0 most commonly for @entity3 ( @entity9 ) and additional @entity2 (x 4). The subjective questionnaire results indicated significant @entity0 satisfaction, with 76% stating they would repeat the surgery and 90% recommending it to another. CONCLUSION: This technically demanding high-risk procedure provides an effective and mechanically superior correction for acute @entity6 in selected adult @entity0 , with high subjective satisfaction.

title: Posterior transvertebral osteotomy for XXXX .

answer: @entity6


abstract: Brain stem auditory evoked response (BAER), visual evoked response (VER) and nerve conduction velocities (NCV) were studied in 18 insulin-dependent @entity1 @entity0 between the ages of 3.5 and 16 years (mean 9.0 +/- 3.2 years). The results were compared with those of age-matched controls. The VER latencies of the @entity1 @entity0 in the right eye and left eye were significantly prolonged when compared with the control group. NCV of n. peroneus and the latency of sensorial n. medianus were significantly impaired when compared with the control group. Although the latencies of waves III, IV and V of the right ear and the interpeak latencies of I-III, I-V, III-V of both ears were prolonged, the comparison with the control group was not significant. The @entity3 levels of the @entity1 @entity0 were significantly higher than those of the control group. There was a positive correlation between the @entity3 and the BAER interpeak latencies of wave III-V in both ears (r: 0.51 p < 0.01). There was also a positive correlation between NCVs of n. peroneus and n. medianus (motor and sensorial) with @entity3 (r: 0.52 p < 0.01) and between VER latencies (r: 0.52 p < 0.01) of both eyes separately. In our study the prolonged latencies of VER and BAER were detected in the absence of clinical @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Brainstem auditory evoked potential, visual evoked potential and nerve conduction velocity and their relation with HbA1c and XXXX in @entity0 with insulin dependent diabetes mellitus.

answer: @entity3


abstract: Brain stem auditory evoked response (BAER), visual evoked response (VER) and nerve conduction velocities (NCV) were studied in 18 insulin-dependent @entity1 @entity0 between the ages of 3.5 and 16 years (mean 9.0 +/- 3.2 years). The results were compared with those of age-matched controls. The VER latencies of the @entity1 @entity0 in the right eye and left eye were significantly prolonged when compared with the control group. NCV of n. peroneus and the latency of sensorial n. medianus were significantly impaired when compared with the control group. Although the latencies of waves III, IV and V of the right ear and the interpeak latencies of I-III, I-V, III-V of both ears were prolonged, the comparison with the control group was not significant. The @entity3 levels of the @entity1 @entity0 were significantly higher than those of the control group. There was a positive correlation between the @entity3 and the BAER interpeak latencies of wave III-V in both ears (r: 0.51 p < 0.01). There was also a positive correlation between NCVs of n. peroneus and n. medianus (motor and sensorial) with @entity3 (r: 0.52 p < 0.01) and between VER latencies (r: 0.52 p < 0.01) of both eyes separately. In our study the prolonged latencies of VER and BAER were detected in the absence of clinical @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Brainstem auditory evoked potential, visual evoked potential and nerve conduction velocity and their relation with HbA1c and @entity3 in XXXX with insulin dependent diabetes mellitus.

answer: @entity0


abstract: The numerical development of @entity2 cells during @entity2 growth and under current forms of therapy is quantitatively described as a fundamental of a scientifically founded anticancer strategy. As to general @entity2 prevention, suppression of @entity1 and reduction of recurrencies, figures are derived, which allow one to assess the minimal number of malignant cells to be killed. The killing potency of current @entity4 has not so far been sufficient enough to have a good chance of achieving these ambitious goals. The main reason for this is the neglect of the @entity3 status of the body and its dynamics. This is a surprising fact, since all immunological mechanisms are known to be energy-, i.e., @entity3 -dependent. The experimentally confirmed correlation between the effectiveness of body defense and the quality of the @entity3 status was the origin of several variants of the @entity3 multistep immunostimulation concept (application of immunostimulators combined with the @entity3 multistep therapy). Clinical results reflect the remarkable increase of cell-killing potency achievable by these measures and give reasons for the adaptation of anticancer strategies to progress in @entity2 immunology. Furthermore, real methodological proposals are made for general @entity2 prevention, suppression of @entity1 , and reduction of recurrences, and the concept of a combined therapy is developed. This therapy comprises the currently accepted measures, such as surgery, irradiation and drugs, and the adjuvant O2 multistep immunostimulation, which is applied threefold according to a particular schedule. The advantage of this combination is that the @entity0 comes first into the enjoyment of all the beneficial effects that established regimens can offer for the particular case. Then and moreover, the @entity0 gains better quality of life, because the adverse side-effects of radiation and drugs are attenuated and, finally, the individual gets a fair chance of stopping the progression of the disease.

title: Adaptation of anticancer strategies to progress in XXXX immunology.

answer: @entity2


abstract: We developed a selection procedure based on the observation that diphtheria toxin kills spheroplasts of @entity0 (Murakami et al., Mol. Cell. Biol. 2:588-592, 1982); this procedure yielded mutants resistant to the in vitro action of the toxin. Spheroplasts of mutagenized @entity0 were transformed in the presence of diphtheria toxin, and the transformed survivors were screened in vitro for toxin-resistant @entity2 . Thirty-one haploid @entity1 ribosylation-negative mutants comprising five complementation groups were obtained by this procedure. The mutants grew normally and were stable to prolonged storage. Heterozygous diploids produced by mating wild-type sensitive cells with the mutants revealed that in each case the resistant phenotype was recessive to the sensitive phenotype. Sporulation of these diploids yielded tetrads in which the resistant phenotype segregated as a single Mendelian character. From these observations, we concluded that these mutants are defective in the enzymatic steps responsible for the posttranslational modification of @entity2 which is necessary for recognition by diphtheria toxin.

title: Diphtheria toxin-resistant mutants of XXXX .

answer: @entity0


abstract: The authors review their first experiences in Hungary with the CT guided percutaneous catheter treatment of @entity4 . Diagnostic @entity1 from abscess was performed in one @entity0 . Percutaneous catheter drainage of @entity4 were performed in 4 @entity0 . There were 4 @entity0 with unilateral and 1 @entity0 with @entity4 . 4 @entity0 had @entity2 , 1 @entity0 had staphylococcal @entity3 . One @entity0 following diagnostic @entity1 was successfully treated with antituberculoutic drugs. All @entity0 treated with percutaneous catheter drainage received medical antituberculoutic or antibiotic therapy and showed excellent clinical and radiological results. There was no complication and there was no need to open surgical drainage in this series. CT guided @entity1 is a valuable tool in the diagnosis of @entity4 as well as in the identification of the exact abscess etiology. Percutaneous drainage represents an efficient and attractive alternative to open surgical drainage in the treatment of @entity4 .

title: [CT-guided percutaneous drainage in the management of XXXX ].

answer: @entity4


abstract: A spontaneous and complete recovery of benign childhood @entity1 with centrotemporal or rolandic spikes (BECT) is taken for granted. However, some authors have reported the occurrence of generalized @entity2 in a few adult @entity0 and in some @entity0 who have @entity2 after a long period without problems. The aims of this study were (a) to search for early predictors of outcome and (b) to ascertain the long-term prognosis of BECT in a large group of @entity0 . An attempt to relocate 268 @entity0 born between 1941 and 1967 and consecutively seen as outpatients was undertaken. The outcome after age 20 is known for only 168. Being adults and cured, the others are no longer in touch with their clinics or have moved. Only one indicator of short-term prognosis was found: The earlier the onset of BECT, the longer the period with @entity2 . Of the 168 @entity0 , 165 are @entity2 -free with follow-up ranging from 7 to 30 years. Three @entity0 experienced generalized @entity2 at age 18, 22-24, and 35. Two apparently had an isolated @entity2 . The occurrence of such @entity2 after recovery from BECT is a rare event (approximately 2% of cases) and a relapse with partial @entity2 is quite uncommon. These @entity0 do not differ from @entity0 remaining @entity2 -free.

title: Prognosis of benign childhood XXXX with centrotemporal spikes: a follow-up study of 168 @entity0 .

answer: @entity1


abstract: A spontaneous and complete recovery of benign childhood @entity1 with centrotemporal or rolandic spikes (BECT) is taken for granted. However, some authors have reported the occurrence of generalized @entity2 in a few adult @entity0 and in some @entity0 who have @entity2 after a long period without problems. The aims of this study were (a) to search for early predictors of outcome and (b) to ascertain the long-term prognosis of BECT in a large group of @entity0 . An attempt to relocate 268 @entity0 born between 1941 and 1967 and consecutively seen as outpatients was undertaken. The outcome after age 20 is known for only 168. Being adults and cured, the others are no longer in touch with their clinics or have moved. Only one indicator of short-term prognosis was found: The earlier the onset of BECT, the longer the period with @entity2 . Of the 168 @entity0 , 165 are @entity2 -free with follow-up ranging from 7 to 30 years. Three @entity0 experienced generalized @entity2 at age 18, 22-24, and 35. Two apparently had an isolated @entity2 . The occurrence of such @entity2 after recovery from BECT is a rare event (approximately 2% of cases) and a relapse with partial @entity2 is quite uncommon. These @entity0 do not differ from @entity0 remaining @entity2 -free.

title: Prognosis of benign childhood @entity1 with centrotemporal spikes: a follow-up study of 168 XXXX .

answer: @entity0


abstract: The effects of intracerebroventricularly (i.c.v.) administered @entity2 and some of its analogues on gastric secretion were studied in @entity0 . The compounds inhibited the gastric output of acid, pepsin and fluid in pylorus-ligated @entity0 in a dose-dependent manner with an order of potency: @entity15 ( @entity15 ) greater than @entity17 ( @entity16 ) greater than @entity17 ( @entity16 ) greater than @entity2 . Pretreatment with 10 and 30 mg/kg of @entity7 i.v. or 5 mg/kg of @entity13 s.c. did not modify the antisecretory effect of 0.1 microgram of @entity15 i.c.v. @entity15 injected i.c.v. did not affect the secretion induced by @entity11 in awake @entity0 subjected to vagotomy or in anaesthetized @entity0 with intact vagi. @entity15 i.c.v. had no effect on the serum concentration of @entity12 . The depletion of brain @entity5 ( @entity4 , @entity3 and @entity1 ) with @entity9 i.c.v. significantly attenuated the inhibitory action of @entity15 . Pretreatment with 10 mg/kg of @entity6 i.v. or @entity10 s.c. did not modify the antisecretory effect of @entity15 . The results indicate that @entity2 inhibits gastric secretion in @entity0 by a decrease in the stimulatory vagal impulses to the stomach, and that it acts in the brain via receptors insensitive to @entity14 . Brain biogenic @entity5 , but not opioid peptides or @entity8 seem to be involved in the central gastric antisecretory action of @entity2 .

title: Central gastric antisecretory action of XXXX in the @entity0 .

answer: @entity2


abstract: The effects of intracerebroventricularly (i.c.v.) administered @entity2 and some of its analogues on gastric secretion were studied in @entity0 . The compounds inhibited the gastric output of acid, pepsin and fluid in pylorus-ligated @entity0 in a dose-dependent manner with an order of potency: @entity15 ( @entity15 ) greater than @entity17 ( @entity16 ) greater than @entity17 ( @entity16 ) greater than @entity2 . Pretreatment with 10 and 30 mg/kg of @entity7 i.v. or 5 mg/kg of @entity13 s.c. did not modify the antisecretory effect of 0.1 microgram of @entity15 i.c.v. @entity15 injected i.c.v. did not affect the secretion induced by @entity11 in awake @entity0 subjected to vagotomy or in anaesthetized @entity0 with intact vagi. @entity15 i.c.v. had no effect on the serum concentration of @entity12 . The depletion of brain @entity5 ( @entity4 , @entity3 and @entity1 ) with @entity9 i.c.v. significantly attenuated the inhibitory action of @entity15 . Pretreatment with 10 mg/kg of @entity6 i.v. or @entity10 s.c. did not modify the antisecretory effect of @entity15 . The results indicate that @entity2 inhibits gastric secretion in @entity0 by a decrease in the stimulatory vagal impulses to the stomach, and that it acts in the brain via receptors insensitive to @entity14 . Brain biogenic @entity5 , but not opioid peptides or @entity8 seem to be involved in the central gastric antisecretory action of @entity2 .

title: Central gastric antisecretory action of @entity2 in the XXXX .

answer: @entity0


abstract: The postural adjustments associated with a @entity3 of the postural muscles themselves have been studied in the legs of normal standing @entity0 . We focussed on the following questions. Do postural adjustments precede the focal movement as in the case of movements of the upper limb? Which muscle(s) are involved in the task of stabilizing posture? Can the same postural muscle be activated in postural stabilization and in @entity2 at the same time, in spite of the opposite changes in activity possibly required by these conditions? Six subjects standing on a dynamometric platform were asked to rise onto the tips their toes by contracting their soleus muscles, or to rock on their heels by contracting their tibialis anterior muscles. The tasks were made in a @entity1 ( @entity1 ) situation or in a self-paced mode, standing either freely or holding onto a stable structure. Surface EMGs of leg and thigh muscles, and the foot-floor reaction forces were recorded. The following results were obtained in the @entity1 mode, standing freely. 1. Rising onto toe tips: a striking silent period in soleus preceded its voluntary activation; during this silent period, a tibialis anterior burst could be observed in three subjects; these anticipatory activities induced a forward sway, as monitored by a change in the force exerted along the x axis of the platform. 2. Rocking on heels: an enhancement in tonic EMG of soleus was observed before tibialis anterior voluntary burst, at a mean latency from the go-signal similar to that of the silent period; this anticipatory activity induced a backward body sway. 3. Choice @entity1 conditions showed that the above anticipatory patterns in muscle activity were pre-programmed, specific for the intended tasks, and closely associated with the focal movement. When both tasks were performed in a self-paced mode, all the above EMG and mechanical features were more pronounced and unfolded in time. If the subjects held onto the frame, the early features in the soleus or tibialis anterior EMG were absent, and the corresponding changes in the foot-floor reaction forces were lacking. The anticipatory phenomena observed are considered postural adjustments because they appear only in the free-standing situation, and induce a body sway in the appropriate direction to counteract the destabilizing thrust due to the @entity3 of soleus or tibialis anterior. The central organization and descending control of posture and movements are briefly discussed in the light of the short latency of the anticipatory phenomena and of their close association with the focal movement.

title: Postural adjustments associated with XXXX of leg muscles in standing @entity0 .

answer: @entity3


abstract: The postural adjustments associated with a @entity3 of the postural muscles themselves have been studied in the legs of normal standing @entity0 . We focussed on the following questions. Do postural adjustments precede the focal movement as in the case of movements of the upper limb? Which muscle(s) are involved in the task of stabilizing posture? Can the same postural muscle be activated in postural stabilization and in @entity2 at the same time, in spite of the opposite changes in activity possibly required by these conditions? Six subjects standing on a dynamometric platform were asked to rise onto the tips their toes by contracting their soleus muscles, or to rock on their heels by contracting their tibialis anterior muscles. The tasks were made in a @entity1 ( @entity1 ) situation or in a self-paced mode, standing either freely or holding onto a stable structure. Surface EMGs of leg and thigh muscles, and the foot-floor reaction forces were recorded. The following results were obtained in the @entity1 mode, standing freely. 1. Rising onto toe tips: a striking silent period in soleus preceded its voluntary activation; during this silent period, a tibialis anterior burst could be observed in three subjects; these anticipatory activities induced a forward sway, as monitored by a change in the force exerted along the x axis of the platform. 2. Rocking on heels: an enhancement in tonic EMG of soleus was observed before tibialis anterior voluntary burst, at a mean latency from the go-signal similar to that of the silent period; this anticipatory activity induced a backward body sway. 3. Choice @entity1 conditions showed that the above anticipatory patterns in muscle activity were pre-programmed, specific for the intended tasks, and closely associated with the focal movement. When both tasks were performed in a self-paced mode, all the above EMG and mechanical features were more pronounced and unfolded in time. If the subjects held onto the frame, the early features in the soleus or tibialis anterior EMG were absent, and the corresponding changes in the foot-floor reaction forces were lacking. The anticipatory phenomena observed are considered postural adjustments because they appear only in the free-standing situation, and induce a body sway in the appropriate direction to counteract the destabilizing thrust due to the @entity3 of soleus or tibialis anterior. The central organization and descending control of posture and movements are briefly discussed in the light of the short latency of the anticipatory phenomena and of their close association with the focal movement.

title: Postural adjustments associated with @entity3 of leg muscles in standing XXXX .

answer: @entity0


abstract: Sexually experienced male @entity0 were injected IP with 0, 0.3, 1.5, 3.0, or 6.0 mg/kg @entity7 . The highest dose was fatal within 48 h of injection. A dose-related deficit in erectile function was observed in ex copula tests 48 h after injection. @entity4 was evident in mating tests 72 h after injection. Hepatic mixed function oxidase activity after 0.3 mg/kg injections was not different from controls, but was diminished by 50% in @entity0 treated with 3.0 mg/kg. The higher @entity6 doses (1.5 and 3.0 mg/kg) were associated with equivalent and marked reductions in circulating @entity2 levels, and lesser decrements in circulating @entity5 levels. The @entity0 treated with 1.5 or 3.0 mg/kg @entity7 lost weight (32 +/- 12 and 39 +/- 9 g, respectively). Relative decapsulated adrenal gland weights were markedly increased in @entity0 treated with 3.0 mg/kg. These data indicate that exposure to @entity6 is associated with alterations in @entity1 , with @entity3 occurring at the lowest dose. The effects on copulatory behavior are especially striking because it requires some weeks for copulatory behavior to wane following castration.

title: @entity6 -induced sexual dysfunction does not involve increased hepatic metabolism of XXXX nor increased circulating levels of @entity5 .

answer: @entity2


abstract: Sexually experienced male @entity0 were injected IP with 0, 0.3, 1.5, 3.0, or 6.0 mg/kg @entity7 . The highest dose was fatal within 48 h of injection. A dose-related deficit in erectile function was observed in ex copula tests 48 h after injection. @entity4 was evident in mating tests 72 h after injection. Hepatic mixed function oxidase activity after 0.3 mg/kg injections was not different from controls, but was diminished by 50% in @entity0 treated with 3.0 mg/kg. The higher @entity6 doses (1.5 and 3.0 mg/kg) were associated with equivalent and marked reductions in circulating @entity2 levels, and lesser decrements in circulating @entity5 levels. The @entity0 treated with 1.5 or 3.0 mg/kg @entity7 lost weight (32 +/- 12 and 39 +/- 9 g, respectively). Relative decapsulated adrenal gland weights were markedly increased in @entity0 treated with 3.0 mg/kg. These data indicate that exposure to @entity6 is associated with alterations in @entity1 , with @entity3 occurring at the lowest dose. The effects on copulatory behavior are especially striking because it requires some weeks for copulatory behavior to wane following castration.

title: @entity6 -induced sexual dysfunction does not involve increased hepatic metabolism of @entity2 nor increased circulating levels of XXXX .

answer: @entity5


abstract: Sexually experienced male @entity0 were injected IP with 0, 0.3, 1.5, 3.0, or 6.0 mg/kg @entity7 . The highest dose was fatal within 48 h of injection. A dose-related deficit in erectile function was observed in ex copula tests 48 h after injection. @entity4 was evident in mating tests 72 h after injection. Hepatic mixed function oxidase activity after 0.3 mg/kg injections was not different from controls, but was diminished by 50% in @entity0 treated with 3.0 mg/kg. The higher @entity6 doses (1.5 and 3.0 mg/kg) were associated with equivalent and marked reductions in circulating @entity2 levels, and lesser decrements in circulating @entity5 levels. The @entity0 treated with 1.5 or 3.0 mg/kg @entity7 lost weight (32 +/- 12 and 39 +/- 9 g, respectively). Relative decapsulated adrenal gland weights were markedly increased in @entity0 treated with 3.0 mg/kg. These data indicate that exposure to @entity6 is associated with alterations in @entity1 , with @entity3 occurring at the lowest dose. The effects on copulatory behavior are especially striking because it requires some weeks for copulatory behavior to wane following castration.

title: XXXX -induced sexual dysfunction does not involve increased hepatic metabolism of @entity2 nor increased circulating levels of @entity5 .

answer: @entity6


abstract: AIMS AND OBJECTIVES: Smoking is one of the major risk factors for @entity0 . This study aims at examining the difference in the periodontal status of current smokers, former smokers, and nonsmokers among the adults of Kothamangalam, Kerala. It investigates the association between the level of cigarette consumption and periodontal @entity2 taking into account the effect of age, gender, and oral hygiene. METHODOLOGY: The study population consisted of 30 subjects and divided into three groups as current, former, and nonsmokers with @entity0 . All clinical parameters were recorded. Smoking assessment was done using a self-reported questionnaire, and statistical analysis was carried out. RESULTS: Current smokers had a higher percentage of sites with mean probing depth, and greater mean clinical attachment level than former smokers and nonsmoker. A significant difference (P < 0.05) was found in clinical @entity2 (CAL) between Group I (current smokers) and III (nonsmokers), that shows the increased risk of current smokers for future periodontal destruction. The CAL for current smokers was 5.20    2.440 and for the nonsmokers was 1.50    1.265. A significant difference (P < 0.05) was found in CAL between Group I and III. SUMMARY AND CONCLUSION: The study revealed a marked association between cigarette smoking and the risk of @entity1 . The increased destruction among current smokers showed a dose-dependent relationship with the amount of cigarette consumption. For former smokers, the duration since quitting smoking was associated with a lower risk for severe @entity1 .

title: The effect of cigarette smoking on the severity of XXXX among adults of Kothamangalam Town, Kerala.

answer: @entity0


abstract: @entity4 is a natural lysosomotropic compound. Concentrations of @entity5 > 2 mM impaired the phagocytic activity of BV-2 cells, an immortalized microglial cell line, as was determined by the uptake of fluorescent latex microspheres of different sizes. In contrast, an increase in the uptake of fluorescent dextran was observed with the elevation in @entity5 concentrations. This indicates that @entity4 affects phagocytotic and pinocytotic activities of BV-2 cells differently. @entity1 - and @entity7 -stimulated secretion of @entity3 as well as LPS-stimulated secretion of @entity2 decreased with an elevation in @entity5 concentrations. The constitutive secretion of @entity3 was not significantly affected by @entity5 . However, an increase in LPS-stimulated @entity3 secretion was observed at 10 mM and 20 mM @entity5 . High concentrations of @entity4 affected the activity of lysosomal enzymes of the BV-2 cells. Acid phosphatase and alpha-glucosidase activities increased with the increase in @entity5 up to 20 mM. The activity of @entity6 was increased at 5 mM, but decreased at higher @entity4 concentrations. The effects of @entity4 on microglial functions are discussed with respect to pathogenetic mechanisms of @entity0 of the Alzheimer type.

title: Effect of XXXX on endocytosis, cytokine production and lysosomal enzyme activity of a microglial cell line.

answer: @entity4


abstract: Antimicrobial resistance in @entity2 non-susceptible @entity3 (CNSAb) is a major public health concern globally. This study determined the antibiotic resistance and molecular epidemiology of CNSAb isolates from a referral burn center in Tehran, Iran. Sixty-nine CNSAb isolates were tested for susceptibility to antimicrobial agents using the E test methodology. Multiple locus variable number tandem repeat analysis (MLVA), Multilocus sequence typing (MLST) and multiplex PCR were performed. PCR assays tested for ambler classes A, B, and D b-lactamases. Detection of ISAba1, characterization of integrons, and biofilm formation were investigated. Fifty-three (77%) isolates revealed XDR phenotypes. High prevalence of bla OXA-23-like (88%) and bla @entity1 (54%) were detected. ISAba1 was detected upstream of bla ADC, bla OXA-23-like and bla OXA51-like genes in, 97, 42, and 26% of isolates, respectively. Thirty-one (45%) isolates were assigned to international clone (IC) variants. MLVA identified 56 distinct types with six clusters and 53 singleton genotypes. Forty previously known MLST sequence types forming 5 clonal complexes were identified. The Class 1 integron (class 1 integrons) gene was identified in 84% of the isolates. The most prevalent (33%) cassette combination was aacA4-catB8-aadA1. The IC variants were predominant in the A. baumannii lineage with the ability to form strong biofilms. The XDR-CNSAb from burned @entity0 in Iran is resistant to various antimicrobials, including @entity4 . This study shows wide genetic diversity in CNSAb. Integrating the new Iranian A. baumannii IC variants into the epidemiologic clonal and susceptibility profile databases can help effective global control measures against the XDR-CNSAb pandemic.

title: Wide distribution of XXXX resistant @entity3 in burns @entity0 in Iran.

answer: @entity2


abstract: Antimicrobial resistance in @entity2 non-susceptible @entity3 (CNSAb) is a major public health concern globally. This study determined the antibiotic resistance and molecular epidemiology of CNSAb isolates from a referral burn center in Tehran, Iran. Sixty-nine CNSAb isolates were tested for susceptibility to antimicrobial agents using the E test methodology. Multiple locus variable number tandem repeat analysis (MLVA), Multilocus sequence typing (MLST) and multiplex PCR were performed. PCR assays tested for ambler classes A, B, and D b-lactamases. Detection of ISAba1, characterization of integrons, and biofilm formation were investigated. Fifty-three (77%) isolates revealed XDR phenotypes. High prevalence of bla OXA-23-like (88%) and bla @entity1 (54%) were detected. ISAba1 was detected upstream of bla ADC, bla OXA-23-like and bla OXA51-like genes in, 97, 42, and 26% of isolates, respectively. Thirty-one (45%) isolates were assigned to international clone (IC) variants. MLVA identified 56 distinct types with six clusters and 53 singleton genotypes. Forty previously known MLST sequence types forming 5 clonal complexes were identified. The Class 1 integron (class 1 integrons) gene was identified in 84% of the isolates. The most prevalent (33%) cassette combination was aacA4-catB8-aadA1. The IC variants were predominant in the A. baumannii lineage with the ability to form strong biofilms. The XDR-CNSAb from burned @entity0 in Iran is resistant to various antimicrobials, including @entity4 . This study shows wide genetic diversity in CNSAb. Integrating the new Iranian A. baumannii IC variants into the epidemiologic clonal and susceptibility profile databases can help effective global control measures against the XDR-CNSAb pandemic.

title: Wide distribution of @entity2 resistant XXXX in burns @entity0 in Iran.

answer: @entity3


abstract: Antimicrobial resistance in @entity2 non-susceptible @entity3 (CNSAb) is a major public health concern globally. This study determined the antibiotic resistance and molecular epidemiology of CNSAb isolates from a referral burn center in Tehran, Iran. Sixty-nine CNSAb isolates were tested for susceptibility to antimicrobial agents using the E test methodology. Multiple locus variable number tandem repeat analysis (MLVA), Multilocus sequence typing (MLST) and multiplex PCR were performed. PCR assays tested for ambler classes A, B, and D b-lactamases. Detection of ISAba1, characterization of integrons, and biofilm formation were investigated. Fifty-three (77%) isolates revealed XDR phenotypes. High prevalence of bla OXA-23-like (88%) and bla @entity1 (54%) were detected. ISAba1 was detected upstream of bla ADC, bla OXA-23-like and bla OXA51-like genes in, 97, 42, and 26% of isolates, respectively. Thirty-one (45%) isolates were assigned to international clone (IC) variants. MLVA identified 56 distinct types with six clusters and 53 singleton genotypes. Forty previously known MLST sequence types forming 5 clonal complexes were identified. The Class 1 integron (class 1 integrons) gene was identified in 84% of the isolates. The most prevalent (33%) cassette combination was aacA4-catB8-aadA1. The IC variants were predominant in the A. baumannii lineage with the ability to form strong biofilms. The XDR-CNSAb from burned @entity0 in Iran is resistant to various antimicrobials, including @entity4 . This study shows wide genetic diversity in CNSAb. Integrating the new Iranian A. baumannii IC variants into the epidemiologic clonal and susceptibility profile databases can help effective global control measures against the XDR-CNSAb pandemic.

title: Wide distribution of @entity2 resistant @entity3 in burns XXXX in Iran.

answer: @entity0


abstract: Despite widespread popular belief in the activation of recurrent @entity4 (HSV) by psychosocial stress, little empirical evidence supports that contention. This study retrospectively examined the role of stress in activation of @entity3 as mediated by social support. @entity0 were 59 volunteers who had self-reported culture-positive genital HSV for at least 10 months. Measures of stress proneness (State-Trait @entity1 Inventory; STAI-Trait), recent stressful events (Schedule of Recent Events; SRE), and subjective appraisal of stress (global self-rating) were administered along with measures of general social support and herpes-specific social support. When retrospective reports of @entity2 were examined using a multiple-regression approach, duration of disease and amount of herpes-specific social support were found to be significant moderators of the relation between stress and number of @entity2 in the preceding 12 months. When duration of disease was short (less than 4 years), stress (SRE) and number of recurrences were positively associated; when disease duration was longer, there was no relationship. Similarly, at low levels of herpes-specific social support, a positive relation between stress (SRE) and number of recurrences was found. However, at higher levels of herpes-specific social support, no association was found. No relation was found between stress proneness (STAI-Trait) and @entity2 . However, subjective appraisal (global rating) of stress in the preceding 12 months was positively and significantly correlated with reported number of recurrences. Results are discussed in terms of their clinical implications.

title: The relationship among XXXX , stress, and social support.

answer: @entity4


abstract: BACKGROUND: A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to @entity1 signals. The purpose of this study was to determine whether rapid weigh gain induced by a high-fat (HF) diet accelerates denervation-induced @entity2 . METHODS: Adult, male @entity0 (C57BL/6) were fed a control or HF (60  % calories as fat) diet for 3  weeks (3wHF). Sciatic nerve was sectioned unilaterally for the final 5 or 14  days of the diet. Soleus and extensor digitorum longus (EDL) muscles were removed and incubated in vitro to determine rates of protein degradation and subsequently homogenized for determination of protein levels of @entity3 , ubiquitination, myosin heavy chain (MHC) distribution, and mitochondrial subunits. RESULTS: When @entity0 were fed the 3wHF diet, whole-body fat mass more than doubled, but basal (innervated) muscle weights, rates of protein degradation, @entity3 content, mitochondrial protein content, and myosin isoform distribution were not significantly different than with the control diet in either soleus or EDL. However in the 14  day denervated soleus, the 3wHF diet significantly augmented loss of mass, proteolysis rate, amount of the autophagosome marker @entity3 II, and the amount of overall ubiquitination as compared to the control fed @entity0 . On the contrary, the 3wHF diet had no significant effect in the EDL on amount of mass loss, proteolysis rate, @entity3 levels, or ubiquitination. Fourteen days denervation also induced a loss of mitochondrial proteins in the soleus but not the EDL, regardless of the diet. CONCLUSIONS: Taken together, a short-term, high-fat diet augments denervation @entity2 by induction of protein degradation in the mitochondria-rich soleus but not in the glycolytic EDL. These findings suggest that the denervation-induced loss of mitochondria and HF diet-induced impairment of mitochondrial function may combine to promote skeletal @entity2 .

title: Short-term, high-fat diet accelerates disuse XXXX and protein degradation in a muscle-specific manner in @entity0 .

answer: @entity1


abstract: BACKGROUND: A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to @entity1 signals. The purpose of this study was to determine whether rapid weigh gain induced by a high-fat (HF) diet accelerates denervation-induced @entity2 . METHODS: Adult, male @entity0 (C57BL/6) were fed a control or HF (60  % calories as fat) diet for 3  weeks (3wHF). Sciatic nerve was sectioned unilaterally for the final 5 or 14  days of the diet. Soleus and extensor digitorum longus (EDL) muscles were removed and incubated in vitro to determine rates of protein degradation and subsequently homogenized for determination of protein levels of @entity3 , ubiquitination, myosin heavy chain (MHC) distribution, and mitochondrial subunits. RESULTS: When @entity0 were fed the 3wHF diet, whole-body fat mass more than doubled, but basal (innervated) muscle weights, rates of protein degradation, @entity3 content, mitochondrial protein content, and myosin isoform distribution were not significantly different than with the control diet in either soleus or EDL. However in the 14  day denervated soleus, the 3wHF diet significantly augmented loss of mass, proteolysis rate, amount of the autophagosome marker @entity3 II, and the amount of overall ubiquitination as compared to the control fed @entity0 . On the contrary, the 3wHF diet had no significant effect in the EDL on amount of mass loss, proteolysis rate, @entity3 levels, or ubiquitination. Fourteen days denervation also induced a loss of mitochondrial proteins in the soleus but not the EDL, regardless of the diet. CONCLUSIONS: Taken together, a short-term, high-fat diet augments denervation @entity2 by induction of protein degradation in the mitochondria-rich soleus but not in the glycolytic EDL. These findings suggest that the denervation-induced loss of mitochondria and HF diet-induced impairment of mitochondrial function may combine to promote skeletal @entity2 .

title: Short-term, high-fat diet accelerates disuse @entity1 and protein degradation in a muscle-specific manner in XXXX .

answer: @entity0


abstract: OBJECTIVE: This study was aimed at optimizing the treatment of @entity4 ( @entity4 ) @entity0 who are candidates for stereotactic radiosurgery (SRS) for brain metastases and harbor activating @entity3 ( @entity3 ) mutations. METHODS: We retrospectively reviewed the medical records from 2005 to 2010 of @entity4 @entity0 with brain metastases harboring an activating @entity3 mutation. @entity0 who received a combination therapy of SRS and @entity3 -tyrosine kinase inhibitor (TKI) for brain metastases and those who received SRS without @entity3 -TKI were compared. The primary endpoint was progression-free survival (PFS) of the brain metastases. RESULTS: Thirty-one @entity0 were eligible for enrolment in this study (SRS with TKI, 18; SRS without TKI, 13). Twenty-two @entity0 (71.0%) were @entity0 and the median overall age was 56.0 years. PFS of @entity2 was not significantly prolonged in SRS with TKI treatment group than in SRS without TKI group (17.0 months vs. 9.0 months, p=0.45). @entity1 control rate was 83.3% in the combination therapy group, and 61.5% in the SRS monotherapy group (p=0.23). There were no severe adverse events related with treatment in both groups. CONCLUSIONS: Therapeutic outcome of concurrent SRS and TKI treatment was not superior to SRS monotherapy, however, there was no additive adverse events related with combined treatment.

title: Effects of an XXXX -Tyrosine Kinase Inhibitor Add-on in Stereotactic Radiosurgery for Brain Metastases Originating from Non-Small-Cell Lung Cancer.

answer: @entity3


abstract: To describe the characteristics of @entity7 related to acute @entity12 ( @entity12 V) infection. We reviewed clinical, electrophysiological and histological data of three @entity0 with @entity7 and positive @entity12 V detection (IgG, IgM and PCR) compatible with @entity5 . The @entity1 fulfilled criteria for @entity10 ( @entity10 ). It could be preceded by or concurrent with a limited @entity9 , but systemic manifestations were absent. The first neurological symptoms were always sensory and localized in a hand. @entity1 was initially limited to a restricted sensory part of a nerve trunk territory. The course was subacute with successive and asymmetric @entity4 . Electromyographic study confirmed the diagnosis of @entity10 with multifocal asymmetric sensory and motor axonal loss in two @entity0 , whereas the @entity1 was purely sensory and limited to two nerves in the other @entity0 . Nerve biopsies showed no evidence of @entity6 but, in one @entity0 , revealed a lymphocytic perivascular infiltrate evocative of @entity11 secondary to an infectious agent. Intravenous immunoglobulin (IVIg) was systematically administered. Long-term outcome was good but with incomplete sensory recovery and, for one @entity0 , persistence of a functional disability. @entity12  V infection should be considered in the etiological assessment of @entity10 , especially in the event of a progressive @entity3 in the hands and a concomitant history of @entity8 . IVIg may be an effective treatment for this @entity2 .

title: XXXX multiplex associated with acute @entity12 infection: characteristics, treatment and outcome.

answer: @entity10


abstract: To describe the characteristics of @entity7 related to acute @entity12 ( @entity12 V) infection. We reviewed clinical, electrophysiological and histological data of three @entity0 with @entity7 and positive @entity12 V detection (IgG, IgM and PCR) compatible with @entity5 . The @entity1 fulfilled criteria for @entity10 ( @entity10 ). It could be preceded by or concurrent with a limited @entity9 , but systemic manifestations were absent. The first neurological symptoms were always sensory and localized in a hand. @entity1 was initially limited to a restricted sensory part of a nerve trunk territory. The course was subacute with successive and asymmetric @entity4 . Electromyographic study confirmed the diagnosis of @entity10 with multifocal asymmetric sensory and motor axonal loss in two @entity0 , whereas the @entity1 was purely sensory and limited to two nerves in the other @entity0 . Nerve biopsies showed no evidence of @entity6 but, in one @entity0 , revealed a lymphocytic perivascular infiltrate evocative of @entity11 secondary to an infectious agent. Intravenous immunoglobulin (IVIg) was systematically administered. Long-term outcome was good but with incomplete sensory recovery and, for one @entity0 , persistence of a functional disability. @entity12  V infection should be considered in the etiological assessment of @entity10 , especially in the event of a progressive @entity3 in the hands and a concomitant history of @entity8 . IVIg may be an effective treatment for this @entity2 .

title: @entity10 multiplex associated with acute XXXX infection: characteristics, treatment and outcome.

answer: @entity12


abstract: BACKGROUND: Craniovertebral junction (CVJ) and @entity7 ( @entity5 ) are both rare, each occurring in 0.3-1.0% of @entity0 . To our knowledge, there are no existing cases reporting these manifestations of @entity5 simultaneously. We report a case of @entity5 involving the left CVJ as well as the skin, and discuss our management while providing a review of the literature. CASE DESCRIPTION: An adult @entity0 was presented with progressive @entity6 associated with the development of several @entity4 . Investigations revealed @entity3 including the left CVJ. Biopsy of the CVJ lesion was unamenable due to proximity of the vertebral artery; therefore, the @entity0 underwent biopsy of the other sites. Histological examination demonstrated features consistent with @entity5 and the @entity0 commenced 12 months of standard anti- @entity5 therapy with cervical spine immobilization. At 2-month review, the @entity0 was well with @entity6 and cutaneous lesions. Repeat imaging at 6 months follow-up demonstrated a stable C1 lesion with no evidence of instability. CONCLUSION: CVJ @entity5 may be treated solely with anti- @entity5 therapy and immobilization to good effect if there is no gross instability or @entity1 . Similarly, @entity7 responds well to standard anti- @entity5 therapy. Our experience suggests that co-existing @entity2 in the CVJ and skin can be simultaneously managed with standard therapy without significant alterations to treatment regimes or prognosis.

title: Nonoperative management of craniovertebral junction and XXXX .

answer: @entity7


abstract: AIM: To assess the DMFT index of @entity0 with Special Health Care Needs (SHCN) in Navi Mumbai. To correlate the DMFT index with @entity2 count in the supragingival bacterial biofilm and with plaque pH. MATERIALS AND METHODS: Dental examination of 158 @entity0 aged 5-18 years was conducted to determine the DMFT/dmft index. @entity1 samples were collected from the buccal surfaces of all teeth. The samples were inoculated in mitis salivarius bacitracin agar medium and incubated at 37  C for 48 h. @entity1 was collected from interproximal sites of the molar area (preferably mandibular) for conducting plaque pH test. Chi-square test and Pearson's correlation were used to find the significance of the study parameters on categorical scale between the two groups. RESULTS: The mean DMFT recorded was 4.90    4.63 and the mean dmft recorded was 1.77    3.14. Mean number of @entity2 colony-forming units found was 2.961 * 10(4). Mean plaque pH recorded was 6.2. CONCLUSION: No statistically significant correlation was found between the DMFT index with the number of @entity2 and plaque pH.

title: DMFT index assessment, plaque pH, and microbiological analysis in XXXX with special health care needs, India.

answer: @entity0


abstract: Hearts from subjects with different ages have different @entity1 signaling. Release of @entity1 from intracellular stores in response to an action potential initiates cardiac contraction. Both depolarization-stimulated and spontaneous @entity1 releases, @entity1 transients and @entity1 sparks, demonstrate the main events of excitation-contraction coupling (ECC). Global increase in free @entity1 concentration ([ @entity1 ]( i )) consists of summation of @entity1 release events in cardiomyocytes. Since the @entity1 flux induced by @entity1 sparks reports a summation of @entity3 -sensitive @entity1 release channels ( @entity4 s)'s behavior in a spark cluster, evaluation of the properties of @entity1 sparks and @entity1 transients may provide insight into the role of @entity4 s on altered heart function between 3-month-old (young adult) and 6-month-old (mature adult) @entity0 . Basal [ @entity1 ]( i ) and @entity1 sparks frequency were significantly higher in mature adult @entity0 compared to those of young adults. Moreover, amplitudes of @entity1 sparks and @entity1 transients were significantly smaller in mature adults than those of young adults with longer time courses. A smaller L-type @entity1 current density and decreased SR @entity1 load was observed in mature adult @entity0 . In addition, @entity4 s were markedly hyperphosphorylated, and phosphorylation levels of PKA and CaMKII were higher in heart from mature adults compared to those of young adults, whereas their SERCA protein levels were similar. Our data demonstrate that hearts from @entity0 with different ages have different @entity1 signaling including hyperphosphorylation of @entity4 s and higher basal [ @entity1 ]( i ) together with increased oxidized protein- @entity2 in mature adult @entity0 compared to those of young adults, which play important roles in ECC. Finally, we report that ECC efficiency changes with age during maturation, partially related with an increased cellular oxidation level leading to reduced free protein- @entity2 in cardiomyocytes.

title: Age-related regulation of excitation-contraction coupling in XXXX heart.

answer: @entity0


abstract: Epidemiologic evidence shows a strong relationship between @entity4 and @entity1 . It was speculated that salt intake might be the linking factor causing @entity2 and @entity8 as well as @entity10 . This study tested whether @entity2 diseases, such as @entity5 and @entity1 , occurred more frequently in @entity0 with @entity4 and gastric @entity7 than expected by chance alone. In addition, it was studied whether gastric and duodenal @entity7 coincided more frequently with other diseases that in the past have been associated with peptic @entity7 , such as @entity9 , @entity6 , and @entity3 . The German statistics of rehabilitation were used to assess the frequency of coincidences. The statistics include a description of the primary, secondary, and tertiary diagnoses leading to rehabilitation. This study confirms the presence of a high coincidence of both @entity7 with @entity9 . In @entity0 with @entity3 , both @entity7 occurred more frequently than expected from their general distribution. Gastric but not duodenal @entity7 coincided more frequently with @entity5 than expected. @entity4 occurred more frequently in @entity0 who had concomitant @entity5 or @entity1 . @entity11 was not associated with an increased risk for any disease related to @entity2 . The results of the study support the contention that @entity10 and diseases related to @entity2 share a common etiologic factor.

title: Concordant occurrence of gastric and XXXX diseases.

answer: @entity2


abstract: AIM: The aim of this study is to present the first total number of tested @entity0 in the Federation of Bosnia and Herzegovina and the number of @entity0 with positive sweat test. During the study we determined the number of ill @entity0 , the median age of @entity0 with @entity1 , date of initial diagnosis, an average amount of @entity2 in the sweat. MATERIAL AND METHODS: The study was a retrospective, conducted at the Department of Pulmonology Pediatric Clinic of University Clinical Center of Sarajevo. RESULTS: In the period from March 2003 to December 2014, we have tested 625 @entity0 . 351 @entity0 were from Sarajevo Canton and 272 @entity0 from other cantons. Female @entity0 were more affected then male @entity0 , in the ratio of 1: 1,105. An average age of female @entity0 was 4.19  4.26 years, and the male 2.15  3.11 years. The median concentration of @entity2 in the sweat measured by sweat test was for male @entity0 103.05  21.29 mmol/L, and for the female @entity0 96.05  28.85 mmol/L. CONCLUSION: Most of @entity0 in Federation of Bosnia and Herzegovina have    F508 gene mutation. In the post-war period we started to use a sweat test. Male @entity0 tend to live longer than female @entity0 with @entity1 .

title: Analysis of XXXX in Federation of Bosnia and Herzegovina.

answer: @entity1


abstract: PURPOSE: One of the major advantages for @entity0 undergoing minimally invasive surgery as compared to an open surgical procedure is the improved recovery profile and decreased opioid requirements in the perioperative period. There are no definitive studies comparing the analgesic requirements in @entity0 undergoing two different types of minimally invasive procedure. This study retrospectively compares the perioperative analgesic requirements in severely @entity1 adolescents and young adults undergoing laparoscopic versus robotic-assisted, laparoscopic gastric sleeve resection. MATERIALS AND METHODS: With Institutional Review Board approval, the medication administration records of all severely @entity1 @entity0 who underwent gastric sleeve resection were retrospectively reviewed. Intra-operative analgesic and adjuvant medications administered, postoperative analgesic requirements, and visual analog @entity2 scores were compared between those undergoing a laparoscopic procedure versus a robotic-assisted procedure. RESULTS: This study cohort included a total of 28 @entity0 who underwent gastric sleeve resection surgery with 14 @entity0 in the laparoscopic group and 14 @entity0 in the robotic-assisted group. Intra-operative adjuvant administration of both intravenous @entity5 and @entity6 was similar in both groups. @entity0 in the robotic-assisted group required significantly less opioid during the intra-operative period as compared to @entity0 in the laparoscopic group (0.15    0.08 mg/kg vs. 0.19    0.06 mg/kg @entity4 , P = 0.024). Cumulative opioid requirements for the first 72 postoperative h were similar in both the groups (0.64    0.25 vs. 0.68    0.27 mg/kg @entity4 , P = NS). No difference was noted in the @entity3 scores. CONCLUSION: Although intraoperative opioid administration was lower in the robotic-assisted group, the postoperative opioid requirements, and the @entity3 scores were similar in both groups.

title: Perioperative analgesic requirements in severely XXXX adolescents and young adults undergoing laparoscopic versus robotic-assisted gastric sleeve resection.

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) of pediatric and adult onset differs in several aspects although little knowledge exists about pathogenic disparity. Regulatory T cells (Tregs) characterized as @entity5 + @entity6 + @entity4 + are modulators of gut homeostasis, but their role in @entity0 @entity1 remains unclear. OBJECTIVE: To evaluate the mucosal distribution of @entity4 + and @entity6 + cells in untreated pediatric @entity1 @entity0 at the time of diagnosis. MATERIAL AND METHODS: Untreated pediatric (n = 14) and adult (n = 12) @entity2 ( @entity2 ) @entity0 were prospectively included together with age-matched symptomatic controls. Colonic and ileal mucosal biopsies collected at diagnosis were studied by immunohistochemistry for enumeration of T cells and for mucosal expression of @entity4 and @entity6 . Multicolor immunofluorescence staining was performed in situ to phenotype @entity4 + cells as Tregs and characterize the @entity6 + cells. RESULTS: The density of @entity3 cells displayed only small variations, while that of @entity4 + cells and @entity6 + cells was increased in @entity2 @entity0 . Multicolor immunofluorescence showed that most @entity6 + cells were macrophages. Interestingly, in the ileum of pediatric @entity2 @entity0 the density of @entity4 + cells was significantly higher than in adult @entity2 @entity0 . Co-expression of @entity4 and @entity6 , as well as @entity4 and @entity7 , indicated that the @entity4 + cells were Tregs. CONCLUSION: Mucosal numbers of @entity4 (+) Tregs and activated ( @entity6 +) macrophages are elevated in both pediatric and adult ileal @entity2 . The greater increase of ileal @entity4 + Tregs in pediatric @entity2 than in adult @entity2 might contribute to the relatively less frequent phenotype of isolated @entity8 in @entity2 @entity0 .

title: Increase of regulatory T cells in ileal mucosa of untreated pediatric XXXX @entity0 .

answer: @entity2


abstract: BACKGROUND: @entity1 ( @entity1 ) of pediatric and adult onset differs in several aspects although little knowledge exists about pathogenic disparity. Regulatory T cells (Tregs) characterized as @entity5 + @entity6 + @entity4 + are modulators of gut homeostasis, but their role in @entity0 @entity1 remains unclear. OBJECTIVE: To evaluate the mucosal distribution of @entity4 + and @entity6 + cells in untreated pediatric @entity1 @entity0 at the time of diagnosis. MATERIAL AND METHODS: Untreated pediatric (n = 14) and adult (n = 12) @entity2 ( @entity2 ) @entity0 were prospectively included together with age-matched symptomatic controls. Colonic and ileal mucosal biopsies collected at diagnosis were studied by immunohistochemistry for enumeration of T cells and for mucosal expression of @entity4 and @entity6 . Multicolor immunofluorescence staining was performed in situ to phenotype @entity4 + cells as Tregs and characterize the @entity6 + cells. RESULTS: The density of @entity3 cells displayed only small variations, while that of @entity4 + cells and @entity6 + cells was increased in @entity2 @entity0 . Multicolor immunofluorescence showed that most @entity6 + cells were macrophages. Interestingly, in the ileum of pediatric @entity2 @entity0 the density of @entity4 + cells was significantly higher than in adult @entity2 @entity0 . Co-expression of @entity4 and @entity6 , as well as @entity4 and @entity7 , indicated that the @entity4 + cells were Tregs. CONCLUSION: Mucosal numbers of @entity4 (+) Tregs and activated ( @entity6 +) macrophages are elevated in both pediatric and adult ileal @entity2 . The greater increase of ileal @entity4 + Tregs in pediatric @entity2 than in adult @entity2 might contribute to the relatively less frequent phenotype of isolated @entity8 in @entity2 @entity0 .

title: Increase of regulatory T cells in ileal mucosa of untreated pediatric @entity2 XXXX .

answer: @entity0


abstract: INTRODUCTION: Aetiology of oral and @entity5 in this country includes @entity1 ( @entity1 ), fall, industrial accidents and others. Among these causes, @entity1 accident is the predominant cause of @entity2 . MATERIALS AND METHODS: A retrospective record review was carried out using hospital records of all @entity0 who sustained oral and maxillofacial injury at the Department of Oral Surgery, Seremban Hospital, Negeri Sembilan, Malaysia between 1998 and 2002. Information related to demographics, aetiology of @entity2 , vehicles involved in collision, location of injuries and treatment modalities were reviewed. RESULTS: Two thousand nine hundred and eighty-six @entity0 sustained oral and @entity5 . Of these @entity0 , 79.2% were @entity0 and the remaining were @entity0 . Among all the races, Malays had the highest involvement (50.6%) followed by Indians (24.5%), Chinese (19.6%) and others (5.3%). There were statistically significant results on the association of aetiology and the ethnic groups, in the age group of 30 years or less and male gender (P < 0.001). The most common injury was the soft-tissue injury followed by dental and @entity2 and bony @entity3 . Among all @entity3 , 66.3% were managed conservatively, 13% were treated surgically and 19.7% did not have any intervention. In relation to dental and @entity2 , 64.8% had treatment in the form of splinting, restorations or dental extraction. The rest of the @entity0 (35.2%) were referred to their dentists or did not have any active treatment at Seremban Hospital. CONCLUSION: Most of the dental and @entity4 in Seremban Hospital were caused by @entity1 and were predominantly managed using conservative methods.

title: A retrospective study of oral and XXXX in Seremban Hospital, Malaysia.

answer: @entity5


abstract: On the morning after taking @entity3 in large amounts together with intranasal @entity10 , a 25-year-old @entity0 experienced @entity2 , swelling and blistering in both arms together with right brachial plexus paresis. @entity5 kinase (1930 U/l), acute phase proteins and IgE (238 IU/ml) were elevated. The @entity2 was largely relieved by @entity9 block (given once only), and the swelling and @entity11 responded to @entity7 (80 mg daily for 7 days, then gradually reduced). Function returned in the lower division of the brachial plexus within ten days, but the upper division was still paretic 2.5 months later. After injecting @entity10 intravenously, a 27-year-old @entity0 woke up next morning with fever (39 degrees C) and proximal flaccid paralysis of the right arm. In addition to leucocytosis (25,600/microliters), @entity5 kinase was raised to 28,890 U/l and pANCA to a titre of 1:50 (antineutrophil cytoplasm antibody, perinuclear fluorescence pattern). The cerebrospinal fluid showed increases in cell count (15/microliters) and protein (73 mg/dl). @entity4 supervened after two days but was successfully treated. The paresis was still present at four months, though improved. A 21-year-old @entity0 developed an upper @entity12 after attempting suicide with intravenous @entity10 accompanied by @entity14 (20 mg by mouth) and a bottle of whisky. She had raised levels of @entity8 (12 mg/dl) and IgM (4.0 milligrams). The paresis cleared up within six weeks without specific therapy. In view of the @entity6 it seems possible that the immune system was involved in the pathogenesis of the @entity1 and the @entity13 .

title: [ @entity12 and @entity13 following XXXX abuse. Indications for an immunological cause].

answer: @entity10


abstract: On the morning after taking @entity3 in large amounts together with intranasal @entity10 , a 25-year-old @entity0 experienced @entity2 , swelling and blistering in both arms together with right brachial plexus paresis. @entity5 kinase (1930 U/l), acute phase proteins and IgE (238 IU/ml) were elevated. The @entity2 was largely relieved by @entity9 block (given once only), and the swelling and @entity11 responded to @entity7 (80 mg daily for 7 days, then gradually reduced). Function returned in the lower division of the brachial plexus within ten days, but the upper division was still paretic 2.5 months later. After injecting @entity10 intravenously, a 27-year-old @entity0 woke up next morning with fever (39 degrees C) and proximal flaccid paralysis of the right arm. In addition to leucocytosis (25,600/microliters), @entity5 kinase was raised to 28,890 U/l and pANCA to a titre of 1:50 (antineutrophil cytoplasm antibody, perinuclear fluorescence pattern). The cerebrospinal fluid showed increases in cell count (15/microliters) and protein (73 mg/dl). @entity4 supervened after two days but was successfully treated. The paresis was still present at four months, though improved. A 21-year-old @entity0 developed an upper @entity12 after attempting suicide with intravenous @entity10 accompanied by @entity14 (20 mg by mouth) and a bottle of whisky. She had raised levels of @entity8 (12 mg/dl) and IgM (4.0 milligrams). The paresis cleared up within six weeks without specific therapy. In view of the @entity6 it seems possible that the immune system was involved in the pathogenesis of the @entity1 and the @entity13 .

title: [ XXXX and @entity13 following @entity10 abuse. Indications for an immunological cause].

answer: @entity12


abstract: On the morning after taking @entity3 in large amounts together with intranasal @entity10 , a 25-year-old @entity0 experienced @entity2 , swelling and blistering in both arms together with right brachial plexus paresis. @entity5 kinase (1930 U/l), acute phase proteins and IgE (238 IU/ml) were elevated. The @entity2 was largely relieved by @entity9 block (given once only), and the swelling and @entity11 responded to @entity7 (80 mg daily for 7 days, then gradually reduced). Function returned in the lower division of the brachial plexus within ten days, but the upper division was still paretic 2.5 months later. After injecting @entity10 intravenously, a 27-year-old @entity0 woke up next morning with fever (39 degrees C) and proximal flaccid paralysis of the right arm. In addition to leucocytosis (25,600/microliters), @entity5 kinase was raised to 28,890 U/l and pANCA to a titre of 1:50 (antineutrophil cytoplasm antibody, perinuclear fluorescence pattern). The cerebrospinal fluid showed increases in cell count (15/microliters) and protein (73 mg/dl). @entity4 supervened after two days but was successfully treated. The paresis was still present at four months, though improved. A 21-year-old @entity0 developed an upper @entity12 after attempting suicide with intravenous @entity10 accompanied by @entity14 (20 mg by mouth) and a bottle of whisky. She had raised levels of @entity8 (12 mg/dl) and IgM (4.0 milligrams). The paresis cleared up within six weeks without specific therapy. In view of the @entity6 it seems possible that the immune system was involved in the pathogenesis of the @entity1 and the @entity13 .

title: [ @entity12 and XXXX following @entity10 abuse. Indications for an immunological cause].

answer: @entity13


abstract: A major surface protein complex from the Florida isolate of @entity2 has been previously shown to induce protection in immunized @entity0 and has been proposed as the basis of a subunit vaccine against @entity1 . This complex in the Florida isolate is composed of two noncovalently associated polypeptides with molecular masses of 105 and 100 kilodaltons (kDa). The analogous protein complex from four geographically different isolates of A. marginale was immunoprecipitated and compared with the protein complex of the Florida isolate. The polypeptides of the complex varied in apparent molecular mass among the isolates. By using antibodies recognizing epitopes on each polypeptide of the Florida isolate, the antigenic identity of the polypeptides in the analogous complexes was determined. The polypeptides recognized by the neutralizing monoclonal antibody 22B1, which recognizes a 105-kDa polypeptide in the Florida isolate, ranged from 70 to 100 kDa in the other isolates. Those polypeptides recognized by rabbit antiserum R911, which recognizes a 100-kDa polypeptide in the Florida isolate, ranged from 97 to 100 kDa. The surface-exposed peptides in the complexes were compared by limited enzymatic digestion to assess structural homology among isolates. Despite the marked variations in molecular weight, there were conserved peptides between the 22B1-reactive polypeptides and between the R911-reactive peptides. Determination of the role of the conserved peptides in inducing immunity will be critical in the application of these polypeptides as the basis of a subunit vaccine for @entity0 @entity1 .

title: Molecular size variations in an immunoprotective protein complex among isolates of XXXX .

answer: @entity2


abstract: Blunt or penetrating @entity6 frequently require fasciotomy. Long term follow-up studies of these @entity0 are rare. From 1976 to 1983, 85 @entity0 underwent 39 fasciotomies upon the upper extremities and 57 upon the lower. Amputations were required in 11 @entity0 ; four due to primary vascular compromise, six to severe @entity2 and one to electric burn with myonecrosis. The fasciotomy was not etiologically related to limb loss in any of these @entity0 . @entity7 occurred in two @entity0 . Long term follow-up data was obtained by telephone and mail survey from 23 of the 61 @entity0 five to 11 years after injury. @entity3 , @entity4 and @entity5 were major determinants of long term morbidity. @entity1 was present in two @entity0 . Seven of the @entity0 interviewed were unemployed due to the injuries they received to the extremities. Most symptoms were believed to be due to the severity of the injury, and none were directly attributed to the fasciotomy. When fasciotomy is indicated, it is a safe adjunctive procedure in limb salvage and contributes very little to the long term morbidity of @entity0 with severe @entity2 to the extremity.

title: Fasciotomy for severe, blunt and penetrating XXXX of the extremity.

answer: @entity2


abstract: This study evaluated the effect of the 270 degrees Belsey @entity2 IV fundoplication on 24 hour ambulatory pH metry variables. Thirty seven @entity0 with confirmed @entity1 who had a Belsey @entity2 IV antireflux procedure were evaluated preoperatively and three to six months postoperatively including endoscopy, lower oesophageal sphincter manometry, and 24 hour ambulatory pH metry. In 30 of 37 @entity0 the Belsey @entity2 IV fundoplication was judged successful based on symptom relief and healing of @entity1 . In these 30 @entity0 percentage reflux for total, upright, and supine time (median and range) decreased significantly (p < 0.001) from 10.0% (2.7-35.3%), 10.8% (3.2-39.9%), and 6.7 (0.0-33.0%) respectively to 0.5% (0.0-7.4%), 0.6% (0.0-13.7%), and 0.1% (0.0-4.9%) after operation. This decrease in reflux time resulted predominantly from a significant (p < 0.001) reduction in the number of reflux episodes from 98 (23-231) to 14 (0-82) postoperatively. Normalisation of total reflux time (upper limit of normal for time with pH below 4:4%) was found in 89% and normalisation of total and upright and supine reflux in 64% of successfully operated @entity0 with confirmed abnormal acid reflux before operation. A successful antireflux procedure was associated with significant (p < 0.001) increases in lower oesophageal sphincter pressure from 7.8 (0.6) mm Hg to 14.5 (0.7) mm Hg mean (SEM). In seven @entity0 with a failed antireflux operation basal lower oesophageal sphincter pressure did not change significant;y (preoperative value 5.7 (1.3) mm Hg; postoperative value 7.8 (0.8) mm Hg). In these @entity0 reflux time did not decrease after the operation and remained in the abnormal range in all @entity0 . It is concluded that a successful, in contrast with a failed, Belsey @entity2 IV fundoplication is associated with significant decreases in total, upright, and supine reflux time. Normalisation of pH metry variables is not a prerequisite for successful antireflux surgery. A surgery. A successful 270 degree Belsey @entity2 IV fundoplication was associated with a significant increase in basal lower oesophageal sphincter pressure, in contrast with the failure group. Restoration of a sufficient lower oesophageal sphincter barrier is an important aim in antireflux surgery.

title: Prospective evaluation of 24 hour ambulatory pH metry in Belsey XXXX IV antireflux surgery.

answer: @entity2


abstract: BACKGROUND: Macrophage precursors are present in embryonic @entity0 shortly after the onset of @entity1 . During organogenesis they soon establish residency in many parts of the body and become convertible into phagocytes, at first gaining morphological characteristics of macrophages and later a range of surface antigens used to characterize subpopulations in adults. Nonetheless, it is uncertain whether representatives of this fetal lineage continue to exist past birth. We investigated the question indirectly by seeing if such cells can be made to survive in vitro to an age equivalent to adulthood and by examining underlying conditions that favor this outcome. METHODS: Fourteen-day embryonic lungs, hearts, and limb buds were organ cultured on a firm serum-containing medium. Fetal macrophages developed within all explants and then migrated out to form a corona of cells surrounding each explant. The lung cultures were selected for subsequent work which mainly used coronal area as the measure of macrophage population size in experimental and control groups. Baseline growth and survival of macrophages were established for cultures grown on standard medium, then effects of the following were examined: @entity5 (10(-6) M) as it influences initial production of macrophages from precursors and later survival of differentiated cells; and @entity7 ( @entity7 ), used alone at moderate dosage (50-100 U), and combined with granulocyte-macrophage CSF (both 200 U), for its importance to long-term survival of the population. Mitogenic influence of @entity7 on differentiated macrophages was demonstrated by uptake of @entity3 . RESULTS: @entity5 inhibited the formation of macrophages from precursors but enhanced the survival of differentiated cells. @entity7 increased @entity3 uptake of differentiated macrophages and permitted coronal growth to continue long past the approximately 30 day limit of controls. Beyond this interval, @entity7 was essential for macrophage survival, since coronas quickly shrank after the cytokine was withdrawn. Administration of the @entity7 / @entity6 mixture to the 2 oldest @entity7 -exposed cultures between 98 and 127 days in vitro resulted in an increase in the number of coronal macrophages (P < 0.001); withdrawal between 129 and 140 days led to a decrease (P < 0.005). Ultimately a few cells were still surviving at 183 days. CONCLUSIONS: Intrinsic factors promote early formation of macrophages within the explants, but the availability of factors is lessened by the anti-inflammatory action of @entity5 . Its later promotion of macrophage survival may be based on suppression of autogenous @entity4 ( @entity2 ) synthesis. @entity7 greatly promotes macrophage survival; in context this is sufficient to show that the fetal macrophage line has a clear potential to survive well into adulthood.

title: Exogenous cytokines enhance survival of macrophages from organ cultured embryonic XXXX tissues.

answer: @entity0


abstract: The anti-tubular basement membrane (TBM) disease was found in own kidneys of BN, but not BN.1 @entity0 , after immunization with BP.1N (or BP) allogeneic kidney homogenate in @entity2 . Both humoral [anti-TBM reaction assessed by direct immunofluorescence (IF)] and cellular response to TBM antigen ( @entity1 and @entity3 ) appeared to be controlled by an MHC-linked Ir gene(s). In the present experiments all of the 54 @entity4 /RT1n heterozygous Bc @entity0 (BN.1B x BN) x BN.1B were found to be anti-TBM positive by direct IF following the immunization mentioned above, as were all (BN.1B x BN)F1 hybrids. Among 51 @entity4 / @entity4 Bc homozygotes, 5 animals formed linear anti-TBM deposition in their own kidneys. The direct IF staining was somewhat weaker than in the preceding groups but continuous. However, circulating anti-TBM antibodies were not proven by indirect IF in these @entity0 . BN animals failed to develop anti-TBM disease not only after syngeneic immunization but also after BN.1B inoculum differing in RT1 antigens alone. Only donor-recipient strain combinations involving non-RT1 differences (BP or BP.1N to BN, BN.1B or BN to BP.1N) were susceptible to the anti-TBM response. Thus the previously revealed adjuvant effect of non-RT1 alloantigenic differences was confirmed, whereas RT1 difference had no such effect nor was involved in it. In conclusion, the main anti-TBM Ir gene seems to be closely linked with, or even included in, the RT1n haplotype in our system of congenic strains. An alternative hypothesis is that there may be two separately functioning Ir genes, one within the RT1n allele and the other in linkage with RT1.

title: Genetic analysis of anti-TBM disease in the XXXX .

answer: @entity0


abstract: Mutations at the folded gastrulation ( @entity1 ) and twisted gastrulation ( @entity2 ) loci interfere with early morphogenetic movements in @entity0 . @entity1 embryos do not form a normal posterior midgut and although their germbands do elongate, they do not extend dorsally. As a result, when normal embryos have fully extended germbands, the germbands in mutant embryos are folded into the interior on the ventral side of the embryo. @entity2 embryos have abnormally deep dorsal folds during early gastrulation, associated with the failure of dorsal cells to slip laterally to make way for the expanding germband. Both @entity1 and @entity2 embryos continue to develop, but form disorganized first instar larvae. @entity1 and @entity2 are zygotically active genes expressed at least by 10 and 20 min after the onset of gastrulation. Both mutations are viable in homozygous germ cells and the wild-type genes need not be expressed during oogenesis for survival of heterozygous progeny. Elimination of @entity1 + gene product from maternal germ cells does, however, affect the extent of folding observed during gastrulation in viable heterozygotes. Analysis of @entity1 adult and larval gynandromorphs indicates that normal folded gastrulation gene function is only required at the posterior region of the embryo, most probably in the cells giving rise to the posterior midgut or proctodeum. The relative survival of @entity1 mosaics suggests that embryos with mosaic "lethal foci" also die during embryogenesis, although the typical @entity1 phenotype is only produced when the entire focus is mutant. In contrast to the @entity1 focus, no particular cell must be wild type in @entity2 mosaics for survival. Wild-type cells on the dorsal side of the embryo, however, are most effective in rescuing the embryo. This indicates that normal @entity2 gene product may be required only on the dorsal side of the embryo, potentially in the region which gives rise to the amnion serosa.

title: Requirements for zygotic gene activity during gastrulation in XXXX .

answer: @entity0


abstract: OBJECTIVE: The authors review their recent experience with resected @entity5 . SUMMARY BACKGROUND DATA: @entity5 has traditionally had a 5-year survival rate less than 10% after curative resection. Recently, several groups have reported markedly improved 5-year survival rates (approaching 25%) for @entity0 undergoing curative resection. METHODS: Institutional experience with 186 consecutive @entity0 (1981-1991) with pathologic diagnoses of @entity3 undergoing pancreatic resection was reviewed. Histologic specimens of all 3-year survivors (n = 31) were re-reviewed by two pathologists, one internal and one external; nonductal @entity4 then were excluded. RESULTS: After histologic re-review, 12 @entity0 did not have @entity3 , leaving a total of 174 @entity0 for analysis (102 @entity0 , 72 @entity0 ; mean age 63 years, range 34-82 years). Mean follow-up was 22 months (range 4-109). Classical pancreaticoduodenectomy was performed in 71%, pylorus-preserving resection in 9%, and total pancreatectomy in 20%. Hospital mortality was 3%. Twenty-eight @entity0 (16%) had macroscopically incomplete resections; 98 (56%) had lymph node @entity1 within the resected specimens, and 21 @entity0 (12%) had extensive perineural invasion. Overall actuarial 5-year survival was 6.8%. Five-year survival was greater for node-negative versus node-positive @entity0 (14% vs. 1%, p < 0.001), and for smaller (< 2 cm) versus larger @entity2 (20% vs. 1%, p < 0.001). The 5-year survival for the subset of @entity0 with negative nodes and no perineural or duodenal invasion (69 @entity0 ) was 23% (p < 0.001). Mean survival of the 12 excluded @entity0 was 53 +/- 7 months compared with 17.5 +/- 1 months in the 174 @entity0 with ductal @entity4 . CONCLUSIONS: Five-year survival for @entity0 undergoing pancreatic resection for lesions deemed to be clinically "curable" intraoperatively and histologically reviewed/confirmed to be @entity5 is approximately 7%. Survival is greater (23%) in the subset of @entity0 with negative nodes and no duodenal or perineural invasions. Pathologic review of all @entity0 with @entity4 is mandatory if survival data are to be meaningful.

title: Long-term survival after resection for XXXX . Is it really improving?

answer: @entity5


abstract: Membrane potentials of medullary chromaffin cells of the adrenal gland of the @entity0 were measured in situ. Resting potential (-54.3 +/- 8.8 mV) depended on extracellular [K+] as predicted by the constant-field equation with a permeability ratio, PNa/PK, of 0.09. Current-voltage (I-V) relationships showed that the current is rectified across the chromaffin cell membrane. A rectification ratio of 0.4 was calculated from the slopes of the I-V curves for positive (41 +/- 26 @entity6 ) and negative (103 +/- @entity6 ) currents. Because input resistance for a resting chromaffin cell in isolation is approximately 5 G omega, the chromaffin cells in situ behave as if they were electrically coupled. Most cells responded to depolarizing current pulses with repetitive action potentials, but only 50% of them showed spontaneous electrical activity. Spontaneous activity was often seen in the presence of @entity2 (3 microM). Although the application of the K+-channel blockers @entity7 and @entity8 greatly increased the amplitude of the action potentials, only @entity8 induced continuous electrical activity. Application of @entity1 ( @entity3 ) always depolarized the cell membrane. This effect was blocked by @entity5 but not by @entity4 , suggesting that ACh stimulation of chromaffin cells in the @entity0 involves activation of muscarinic receptors.

title: Electrical activity in chromaffin cells of intact XXXX adrenal gland.

answer: @entity0


abstract: Pavlovian control of tolerance to the sedative and hypothermic effects of @entity4 ( @entity5 ) was demonstrated in two experiments. In Experiment I, drug-experienced @entity1 were repeatedly treated with @entity5 (30 mg/kg) in one environment (CS+); on alternate days, they were given saline injections in a different environment (CS-). @entity0 and inactivity were used as measures of sedation. A comparable conditioning procedure was used in Experiment II, but tolerance to the hypothermic effect of @entity5 was the dependent measure. During tolerance testing, @entity1 from both Experiments I and II were given @entity5 in one of three environments, CS+, CS-, or a novel environment (CSnov). In Experiment I, @entity1 were equally tolerant in all three test environments when duration of sleep was assessed. However, when inactivity was used as the measure of tolerance, @entity1 showed tolerance in CS+ and CS-, and significantly less tolerance in CSnov. Drug-naive controls showed similar nontolerant responses to @entity5 in all environments, thus ruling out the possibility that the effect of sedation was mediated nonassociatively. In Experiment II, drug-experienced @entity1 showed tolerance to @entity5 -induced @entity3 in CS+ and CS- but less tolerance in CSnov. A compensatory @entity2 was observed when these @entity1 were given saline in CS+. There was some evidence for a generalization gradient in the conditional control of tolerance in both experiments.

title: Associative control of tolerance to the sedative and hypothermic effects of XXXX .

answer: @entity4


abstract: BACKGROUND: Internet-delivered mental health (eMental Health) interventions produce treatment effects similar to those observed in face-to-face treatment. However, there is a large degree of variation in treatment effects observed from program to program, and eMental Health interventions remain somewhat of a black box in terms of the mechanisms by which they exert their therapeutic benefit. Trials of eMental Health interventions typically use large sample sizes and therefore provide an ideal context within which to systematically investigate the therapeutic benefit of specific program features. Furthermore, the growth and impact of mobile phone technology within eMental Health interventions provides an opportunity to examine associations between symptom improvement and the use of program features delivered across computer and mobile phone platforms. OBJECTIVE: The objective of this study was to identify the patterns of program usage associated with treatment outcome in a @entity1 ( @entity1 ) of a fully automated, mobile phone- and Web-based self-help program, "myCompass", for individuals with mild-to-moderate symptoms of @entity5 , @entity4 , and/or stress. The core features of the program include interactive psychotherapy modules, a symptom tracking feature, short motivational messages, symptom tracking reminders, and a diary, with many of these features accessible via both computer and mobile phone. METHODS: Patterns of program usage were recorded for 231 @entity0 with mild-to-moderate @entity5 , @entity4 , and/or stress, and who were randomly allocated to receive access to myCompass for seven weeks during the @entity1 . @entity5 , @entity4 , stress, and functional impairment were examined at baseline and at eight weeks. RESULTS: Log data indicated that the most commonly used components were the short motivational messages (used by 68.4%, 158/231 of @entity0 ) and the symptom tracking feature (used by 61.5%, 142/231 of @entity0 ). Further, after controlling for baseline symptom severity, increased use of these alert features was associated with significant improvements in @entity2 . Associations between use of symptom tracking reminders and improved treatment outcome remained significant after controlling for frequency of symptom tracking. Although correlations were not statistically significant, reminders received via @entity3 (ie, text message) were more strongly associated with symptom reduction than were reminders received via email. CONCLUSIONS: These findings indicate that alerts may be an especially potent component of eMental Health interventions, both via their association with enhanced program usage, as well as independently. Although there was evidence of a stronger association between symptom improvement and use of alerts via the mobile phone platform, the degree of overlap between use of email and @entity3 alerts may have precluded identification of alert delivery modalities that were most strongly associated with symptom reduction. Future research using random assignment to computer and mobile delivery is needed to fully determine the most ideal platform for delivery of this and other features of online interventions. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ACTRN): 12610000625077; http://www.anzctr.org.au/TrialSearch.aspx? (Archived by WebCite http://www.webcitation.org/6WPqHK0mQ).

title: Breaking Open the Black Box: Isolating the Most Potent Features of a Web and Mobile Phone-Based Intervention for XXXX , @entity4 , and Stress.

answer: @entity5


abstract: BACKGROUND: Internet-delivered mental health (eMental Health) interventions produce treatment effects similar to those observed in face-to-face treatment. However, there is a large degree of variation in treatment effects observed from program to program, and eMental Health interventions remain somewhat of a black box in terms of the mechanisms by which they exert their therapeutic benefit. Trials of eMental Health interventions typically use large sample sizes and therefore provide an ideal context within which to systematically investigate the therapeutic benefit of specific program features. Furthermore, the growth and impact of mobile phone technology within eMental Health interventions provides an opportunity to examine associations between symptom improvement and the use of program features delivered across computer and mobile phone platforms. OBJECTIVE: The objective of this study was to identify the patterns of program usage associated with treatment outcome in a @entity1 ( @entity1 ) of a fully automated, mobile phone- and Web-based self-help program, "myCompass", for individuals with mild-to-moderate symptoms of @entity5 , @entity4 , and/or stress. The core features of the program include interactive psychotherapy modules, a symptom tracking feature, short motivational messages, symptom tracking reminders, and a diary, with many of these features accessible via both computer and mobile phone. METHODS: Patterns of program usage were recorded for 231 @entity0 with mild-to-moderate @entity5 , @entity4 , and/or stress, and who were randomly allocated to receive access to myCompass for seven weeks during the @entity1 . @entity5 , @entity4 , stress, and functional impairment were examined at baseline and at eight weeks. RESULTS: Log data indicated that the most commonly used components were the short motivational messages (used by 68.4%, 158/231 of @entity0 ) and the symptom tracking feature (used by 61.5%, 142/231 of @entity0 ). Further, after controlling for baseline symptom severity, increased use of these alert features was associated with significant improvements in @entity2 . Associations between use of symptom tracking reminders and improved treatment outcome remained significant after controlling for frequency of symptom tracking. Although correlations were not statistically significant, reminders received via @entity3 (ie, text message) were more strongly associated with symptom reduction than were reminders received via email. CONCLUSIONS: These findings indicate that alerts may be an especially potent component of eMental Health interventions, both via their association with enhanced program usage, as well as independently. Although there was evidence of a stronger association between symptom improvement and use of alerts via the mobile phone platform, the degree of overlap between use of email and @entity3 alerts may have precluded identification of alert delivery modalities that were most strongly associated with symptom reduction. Future research using random assignment to computer and mobile delivery is needed to fully determine the most ideal platform for delivery of this and other features of online interventions. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ACTRN): 12610000625077; http://www.anzctr.org.au/TrialSearch.aspx? (Archived by WebCite http://www.webcitation.org/6WPqHK0mQ).

title: Breaking Open the Black Box: Isolating the Most Potent Features of a Web and Mobile Phone-Based Intervention for @entity5 , XXXX , and Stress.

answer: @entity4


abstract: The aortic wall of the @entity0 ascending aorta from 44 @entity0 operated on for @entity6 ( @entity6 ) was studied. Light microscopy revealed significantly greater cystic change, @entity5 , @entity2 and disappearance of smooth muscle cells in aortic media in @entity6 than in control specimens taken at autopsy. Occasional aortae, however, were morphologically almost normal. Eight of the @entity0 had @entity4 . No significant differences were observed between them and the other 36 @entity0 , except for a tendency to have less pronounced @entity2 . There were 9 @entity0 who, in addition to the changes mentioned, had advanced @entity3 , and their aortae showed more extensive @entity2 and medial @entity1 . Pooling of proteoglycan matrix, degeneration of elastic lamellae, increased amount of collagen and @entity1 of smooth muscle cells characterized the electron microscopic findings of 13 @entity0 . The collagen fibers seemed to be of normal shape. In conclusion, changes in @entity6 are characterized by severe @entity1 . The changes are basically similar in Marfan and non-Marfan @entity0 .

title: XXXX . Light and electron microscopic changes in aortic media.

answer: @entity6