abstract: BACKGROUND: An increase of @entity6 ( @entity6 ) has been described in blood mononuclear white cells of @entity0 with @entity4 ( @entity4 ). This study was intended to search for the putative relationship between @entity1 and @entity6 in inflammatory cells. MATERIAL/METHODS: The @entity0 monocyte cell line U-937 was used as a model of blood mononuclear leucocytes. @entity6 activity was determined as the increase of @entity2 degradation, which is specifically inhibited by @entity9 . Intracellular @entity2 content was measured and correlated to @entity6 activity. RESULTS: 1 microM @entity1 produced a 2- to 3-fold selective increase in @entity6 activity in U-937 cells after 4 hours of incubation. Enzyme activation was reversible, concentration- and time dependent. @entity5 (10 microM) prevented @entity1 -induced stimulation of @entity6 . The H2-receptor antagonist, @entity8 , but not the H1-receptor antagonist, @entity7 , prevented @entity1 -induced activation of @entity6 in a concentration-dependent manner. Inhibition of @entity2 degradation in the presence of @entity1 plus rolipram after 4 h of incubation further increased @entity2 levels and @entity6 activity. CONCLUSIONS: These results suggest that @entity1 -induced stimulation of @entity6 is mediated by the H2 receptor and related to intracellular levels of @entity2 . AMPc enhancement of the cyclic @entity3 levels may trigger expression and synthesis of this enzyme.

title: XXXX up-regulates phosphodiesterase IV activity in U-937 cells through H2 receptor stimulation and @entity2 increase.

answer: @entity1


abstract: @entity1 has become a serious problem in clinical practice, but the actual factor that confers virulence on the fungus has not been thoroughly elucidated. To identify and isolate the immunosuppressive substances produced by the fungus, the bioactivity of culture filtrates was assessed, and analyses of the culture filtrates were carried out. Culture filtrates from different strains of @entity3 were assessed for their effect on @entity0 polymorphonuclear leukocytes and @entity2 macrophages. To assess their activities in vivo, their effect on the survival of @entity2 infected by the fungus was also studied. Subsequently, the composition of the culture filtrates was analyzed by gas chromatography-mass spectrometry. The analyses revealed that the culture filtrates contained @entity5 at concentrations of 3 to 4 microgram/ml, and some other unidentified compounds. The bioactivities of the culture filtrates were similar to those of @entity5 . The fungal culture filtrate reduced the survival of infected @entity2 , but the filtrate itself did not cause the @entity4 of @entity2 . However, all the bioactivities could not be accounted for by @entity5 itself. These results indicate that @entity5 in the culture filtrates may be responsible for part of the immunosuppressive activity, but some other components produced by A. fumigatus contribute, in an additive or synergistic manner, to the virulence of the fungus.

title: Immunosuppressive substances in XXXX culture filtrate.

answer: @entity3


abstract: The induction of @entity0 was investigated by culturing diploid @entity1 @entity1 D7 cells continuously at radiation levels ranging from 0.383 microSv/h to 1.275 @entity2 /h by selecting appropriate concentrations of tritiated water in the growth medium. These radiation levels correspond to 3-10,000 times the natural background. Parameters such as growth kinetics, gene conversion frequency at background radiation and after a challenging dose of acute gamma-radiation or alkylating agent @entity3 ( @entity3 ) were assessed. The gene conversion frequency in most of the assays was in the range of 5-10 convertants per 10(6) cells, as in the case of controls. However, a number of the cultures showed conversion frequencies above 20 per 10(6) viable cells. This stochastic phenomenon occurred more frequently in cells which were incubated at higher radiation levels and for longer durations. This suggests that radiation is responsible for the phenomenon. When subculturing continued beyond 900 h, gene conversion frequencies reverted back to normal values in all cultures in spite of elevated background radiation levels, thus suggesting an adaptive response. The generation time of the cells was 78 min in all cultures irrespective of the radiation level. The response of the cells cultured at elevated background radiation levels to subsequent challenging treatment with gamma-radiation or @entity3 was identical to that of the control cultures. Our results suggest that in eukaryotic @entity1 , low-level radiation may induce an adaptive response to chronic radiation, whereas no such response could be detected when the cells were challenged with acute high-dose exposure or with @entity3 .

title: Induction of gene conversion in XXXX cells continuously cultured at high radiation background.

answer: @entity1


abstract: The six haem groups of the @entity1 reductase enzyme isolated from @entity3 are rapidly reduced by the addition of @entity2 ( @entity4 ). The reduction, however, is not homogeneous. Two of the haem groups, namely those that show spectral characteristics typical of five-co-ordinated haem groups, are reduced in a @entity2 -concentration-dependent fashion with a rate limit of 1.5 S-1. The other four haem groups, which show spectral characteristics very similar to those of normal six-co-ordinate c-haem groups, reduce in a linear @entity2 -concentration-dependent manner with a second-order rate constant of 150 M-1/2 X S-1. The ratio of the amplitudes of the two reduction phases observed in stopped-flow studies is found to be dependent on the concentration of @entity2 used. A model is proposed to account for these observations, and computer simulations show that the model represents a good fit to the experimental data. The two haem groups with five-co-ordinate spectral characteristics bind CO. Flash photolysis of the CO complex exhibits one major recombination process with a linear @entity0 in rate on CO concentration with a second-order rate constant of 2 X 10(6) M-1 X S-1. By contrast, stopped-flow mixing of the reduced protein with CO shows a very complex pattern of combination, with most of the observed absorbance change associated with a concentration-independent step. These findings are rationalized in terms of structural changes in the protein consequent to ligand binding.

title: Kinetic studies on the @entity1 reductase of XXXX .

answer: @entity3


abstract: The six haem groups of the @entity1 reductase enzyme isolated from @entity3 are rapidly reduced by the addition of @entity2 ( @entity4 ). The reduction, however, is not homogeneous. Two of the haem groups, namely those that show spectral characteristics typical of five-co-ordinated haem groups, are reduced in a @entity2 -concentration-dependent fashion with a rate limit of 1.5 S-1. The other four haem groups, which show spectral characteristics very similar to those of normal six-co-ordinate c-haem groups, reduce in a linear @entity2 -concentration-dependent manner with a second-order rate constant of 150 M-1/2 X S-1. The ratio of the amplitudes of the two reduction phases observed in stopped-flow studies is found to be dependent on the concentration of @entity2 used. A model is proposed to account for these observations, and computer simulations show that the model represents a good fit to the experimental data. The two haem groups with five-co-ordinate spectral characteristics bind CO. Flash photolysis of the CO complex exhibits one major recombination process with a linear @entity0 in rate on CO concentration with a second-order rate constant of 2 X 10(6) M-1 X S-1. By contrast, stopped-flow mixing of the reduced protein with CO shows a very complex pattern of combination, with most of the observed absorbance change associated with a concentration-independent step. These findings are rationalized in terms of structural changes in the protein consequent to ligand binding.

title: Kinetic studies on the XXXX reductase of @entity3 .

answer: @entity1


abstract: @entity2 is very rare with atypical glandular features, that may appear initially as a chalazion formation and then invades the neighbouring tissues. PURPOSE: Demonstration of the importance of surgical excision and histological examination in presence of an apparently harmless tumoral alteration of the eyelids and verifying every case of atypical lesion of the eyelid region. Case presentation No. 1: We report a case of 76-year old @entity0 @entity0 suffering from chronical blepharoconjunctivitis and chronical chalazion many times simply performed excochleation. Histopathological finding of the excision of the @entity1 showed the presence of @entity2 Meibomian gland (stage G2), the @entity0 refused exenteration and died in 2 month interval. Case presentation No. 2.: 65-year old @entity0 with @entity2 .sin. (T3 N2 M0) in 1998 after hemiglossectomia, resectionem baseos oris 1.sin. and radiotherapy, came to our clinic with exoftalm and @entity1 in his right orbit in @entity3 2001. CT found @entity1 3 x 2 x 2 cm. In September 2001 orbitotomia bicoronalis 1.sin., extirpatio TU orbitae 1.sin. histologically verified karcinoma of Meibomain gland, @entity0 without any problems after operation and radiotherapy.

title: [ XXXX arising from a Meibomian gland].

answer: @entity2


abstract: Bangladesh suffered the century's worst flood during July-October 1998 and appealed for assistance. To provide information for appropriate interventions to tackle nutritional problems, a rapid assessment survey was conducted to look at the nutritional situation, problems encountered by the community, their coping mechanisms and rehabilitation priorities in six rural areas. The survey was repeated after four months to measure the outcome of activities during the flood and the necessity for future assistance. There were 3,048 @entity0 measured in both surveys (1,597 and 1,451). The sample of most interest was a sub-group of 180 @entity0 present in two previous independent surveys. The analysis found that while moving from the crisis period to post-flood phase there was evidence of a 'crossover phenomenon' in the recovery pattern of nutritional status. Sixty-eight per cent of the @entity0 who were malnourished (WHZ < -2SD) during the crisis period (18 per cent) recovered enough to cross the cut-off point and became normal after four months. Another 8 per cent of @entity0 (9 per cent of all normal) who were normal during the crisis period, after four months had deteriorated to be malnourished. Thus, despite there being a shift in the overall distribution of nutritional status, there has been another shift that reduced the net effect. Subsequent episodes of @entity1 , access to food and loan burden had also influenced the recovery pattern of the @entity0 's nutritional status as evident from the statistically significant associations. These findings raise questions about targeting acute @entity2 during emergencies, and using the same criteria during both the crisis and rehabilitation phases.

title: The 1998 flood in Bangladesh: is different targeting needed during emergencies and recovery to tackle XXXX ?

answer: @entity2


abstract: The aim of the present study was to assess the procedural safety and in-hospital and long-term effectiveness of heparin-coated Jostents after failed thrombolysis in acute @entity5 . We prospectively analyzed the acute and long-term clinical and angiographic outcomes of 35 consecutive @entity0 treated with heparin-coated Jostents for @entity1 . Rescue coronary stenting was successful in 34 of 35 @entity0 (97%). Thrombolysis in Myocardial Infarction flow grade 3 was obtained in 31 @entity0 (88.5%). The only @entity0 with procedural failure died from @entity8 a day after the procedure. One @entity0 (2.8%) underwent an emergency coronary bypass operation because of angiographic evidence of stent @entity6 with re- @entity7 . During in-hospital follow-up, 2 @entity0 (5.7%) underwent an elective coronary bypass operation after successful stent implantation of the @entity7 because of existing severe multivessel @entity3 . Minor @entity4 complications at the vascular access site occurred in 3 (8.6%) @entity0 . No cerebrovascular or any other major @entity4 complication occurred. One @entity0 (2.1%) underwent repeat coronary angioplasty for @entity2 and an elective coronary artery bypass operation was performed in one @entity0 (2.8%) during the 294 +/- 150 days follow-up. The rate of target vessel revascularization was 14.3% and the event-free survival rate was 80%. Twenty-six @entity0 (90%) had angiographic follow-up at six months, and stent @entity2 was found in 5 (19.2%). This study demonstrates that heparin-coated Jostents are sale, with low in-hospital and long-term mortality rates for the treatment of failed thrombolysis in acute @entity5 . The angiographic @entity2 and target vessel revascularization rates of this registry are also acceptable.

title: Rescue coronary stenting with heparin-coated Jostents for failed thrombolysis in acute XXXX .

answer: @entity5


abstract: Microcalcifications containing @entity5 (HA) are often associated with malignant @entity1 breast lesions. Frequently, they are the only mammographic features that indicate the presence of a @entity2 . We previously reported the induction of both mitogenesis and @entity7 ( @entity7 ) production and the increased activities of matrix metalloproteinases (MMPs) @entity8 and @entity9 in normal @entity1 mammary epithelial cells and @entity0 cell lines, treated with HA. In the present study we attempted to elucidate the mechanism of these biological effects. Firstly, we found that direct cell-crystal contact was required for induction of mitogenesis as the effect was not merely a result of isotopic exchange of @entity4 into the culture medium. Treatment with @entity12 , a proton pump inhibitor, abrogated HA-induced mitogenesis to control cell levels. These results suggest that phagocytosis and intracellular crystal dissolution is required for HA-induced mitogenesis. We also demonstrated that the increase in @entity7 , previously reported, is due, at least in part, to HA-induced upregulation of @entity11 ( @entity11 ) in Hs578T cells. An accumulation of @entity10 mRNA was also shown in response to HA stimulation in Hs578T cells. Furthermore, a HA-induced increase in @entity6 ( @entity6 ), a potent inducer of @entity10 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with @entity13 (PC) (a naturally occurring inhibitor of @entity3 crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, @entity11 , @entity10 and @entity6 induction, at the transcriptional level. These results show that @entity4 HA crystals are capable of exerting significant biological effects on surrounding cells which can be abrogated by PC and emphasise the role of @entity4 HA in amplifying the pathological process involved in @entity0 .

title: @entity13 inhibits @entity5 induced mitogenesis and upregulation of @entity10 , XXXX and @entity11 mRNA in @entity1 @entity0 cell lines.

answer: @entity6


abstract: Microcalcifications containing @entity5 (HA) are often associated with malignant @entity1 breast lesions. Frequently, they are the only mammographic features that indicate the presence of a @entity2 . We previously reported the induction of both mitogenesis and @entity7 ( @entity7 ) production and the increased activities of matrix metalloproteinases (MMPs) @entity8 and @entity9 in normal @entity1 mammary epithelial cells and @entity0 cell lines, treated with HA. In the present study we attempted to elucidate the mechanism of these biological effects. Firstly, we found that direct cell-crystal contact was required for induction of mitogenesis as the effect was not merely a result of isotopic exchange of @entity4 into the culture medium. Treatment with @entity12 , a proton pump inhibitor, abrogated HA-induced mitogenesis to control cell levels. These results suggest that phagocytosis and intracellular crystal dissolution is required for HA-induced mitogenesis. We also demonstrated that the increase in @entity7 , previously reported, is due, at least in part, to HA-induced upregulation of @entity11 ( @entity11 ) in Hs578T cells. An accumulation of @entity10 mRNA was also shown in response to HA stimulation in Hs578T cells. Furthermore, a HA-induced increase in @entity6 ( @entity6 ), a potent inducer of @entity10 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with @entity13 (PC) (a naturally occurring inhibitor of @entity3 crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, @entity11 , @entity10 and @entity6 induction, at the transcriptional level. These results show that @entity4 HA crystals are capable of exerting significant biological effects on surrounding cells which can be abrogated by PC and emphasise the role of @entity4 HA in amplifying the pathological process involved in @entity0 .

title: @entity13 inhibits @entity5 induced mitogenesis and upregulation of @entity10 , @entity6 and XXXX mRNA in @entity1 @entity0 cell lines.

answer: @entity11


abstract: Microcalcifications containing @entity5 (HA) are often associated with malignant @entity1 breast lesions. Frequently, they are the only mammographic features that indicate the presence of a @entity2 . We previously reported the induction of both mitogenesis and @entity7 ( @entity7 ) production and the increased activities of matrix metalloproteinases (MMPs) @entity8 and @entity9 in normal @entity1 mammary epithelial cells and @entity0 cell lines, treated with HA. In the present study we attempted to elucidate the mechanism of these biological effects. Firstly, we found that direct cell-crystal contact was required for induction of mitogenesis as the effect was not merely a result of isotopic exchange of @entity4 into the culture medium. Treatment with @entity12 , a proton pump inhibitor, abrogated HA-induced mitogenesis to control cell levels. These results suggest that phagocytosis and intracellular crystal dissolution is required for HA-induced mitogenesis. We also demonstrated that the increase in @entity7 , previously reported, is due, at least in part, to HA-induced upregulation of @entity11 ( @entity11 ) in Hs578T cells. An accumulation of @entity10 mRNA was also shown in response to HA stimulation in Hs578T cells. Furthermore, a HA-induced increase in @entity6 ( @entity6 ), a potent inducer of @entity10 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with @entity13 (PC) (a naturally occurring inhibitor of @entity3 crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, @entity11 , @entity10 and @entity6 induction, at the transcriptional level. These results show that @entity4 HA crystals are capable of exerting significant biological effects on surrounding cells which can be abrogated by PC and emphasise the role of @entity4 HA in amplifying the pathological process involved in @entity0 .

title: @entity13 inhibits XXXX induced mitogenesis and upregulation of @entity10 , @entity6 and @entity11 mRNA in @entity1 @entity0 cell lines.

answer: @entity5


abstract: Microcalcifications containing @entity5 (HA) are often associated with malignant @entity1 breast lesions. Frequently, they are the only mammographic features that indicate the presence of a @entity2 . We previously reported the induction of both mitogenesis and @entity7 ( @entity7 ) production and the increased activities of matrix metalloproteinases (MMPs) @entity8 and @entity9 in normal @entity1 mammary epithelial cells and @entity0 cell lines, treated with HA. In the present study we attempted to elucidate the mechanism of these biological effects. Firstly, we found that direct cell-crystal contact was required for induction of mitogenesis as the effect was not merely a result of isotopic exchange of @entity4 into the culture medium. Treatment with @entity12 , a proton pump inhibitor, abrogated HA-induced mitogenesis to control cell levels. These results suggest that phagocytosis and intracellular crystal dissolution is required for HA-induced mitogenesis. We also demonstrated that the increase in @entity7 , previously reported, is due, at least in part, to HA-induced upregulation of @entity11 ( @entity11 ) in Hs578T cells. An accumulation of @entity10 mRNA was also shown in response to HA stimulation in Hs578T cells. Furthermore, a HA-induced increase in @entity6 ( @entity6 ), a potent inducer of @entity10 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with @entity13 (PC) (a naturally occurring inhibitor of @entity3 crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, @entity11 , @entity10 and @entity6 induction, at the transcriptional level. These results show that @entity4 HA crystals are capable of exerting significant biological effects on surrounding cells which can be abrogated by PC and emphasise the role of @entity4 HA in amplifying the pathological process involved in @entity0 .

title: @entity13 inhibits @entity5 induced mitogenesis and upregulation of XXXX , @entity6 and @entity11 mRNA in @entity1 @entity0 cell lines.

answer: @entity10


abstract: Microcalcifications containing @entity5 (HA) are often associated with malignant @entity1 breast lesions. Frequently, they are the only mammographic features that indicate the presence of a @entity2 . We previously reported the induction of both mitogenesis and @entity7 ( @entity7 ) production and the increased activities of matrix metalloproteinases (MMPs) @entity8 and @entity9 in normal @entity1 mammary epithelial cells and @entity0 cell lines, treated with HA. In the present study we attempted to elucidate the mechanism of these biological effects. Firstly, we found that direct cell-crystal contact was required for induction of mitogenesis as the effect was not merely a result of isotopic exchange of @entity4 into the culture medium. Treatment with @entity12 , a proton pump inhibitor, abrogated HA-induced mitogenesis to control cell levels. These results suggest that phagocytosis and intracellular crystal dissolution is required for HA-induced mitogenesis. We also demonstrated that the increase in @entity7 , previously reported, is due, at least in part, to HA-induced upregulation of @entity11 ( @entity11 ) in Hs578T cells. An accumulation of @entity10 mRNA was also shown in response to HA stimulation in Hs578T cells. Furthermore, a HA-induced increase in @entity6 ( @entity6 ), a potent inducer of @entity10 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with @entity13 (PC) (a naturally occurring inhibitor of @entity3 crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, @entity11 , @entity10 and @entity6 induction, at the transcriptional level. These results show that @entity4 HA crystals are capable of exerting significant biological effects on surrounding cells which can be abrogated by PC and emphasise the role of @entity4 HA in amplifying the pathological process involved in @entity0 .

title: XXXX inhibits @entity5 induced mitogenesis and upregulation of @entity10 , @entity6 and @entity11 mRNA in @entity1 @entity0 cell lines.

answer: @entity13


abstract: Microcalcifications containing @entity5 (HA) are often associated with malignant @entity1 breast lesions. Frequently, they are the only mammographic features that indicate the presence of a @entity2 . We previously reported the induction of both mitogenesis and @entity7 ( @entity7 ) production and the increased activities of matrix metalloproteinases (MMPs) @entity8 and @entity9 in normal @entity1 mammary epithelial cells and @entity0 cell lines, treated with HA. In the present study we attempted to elucidate the mechanism of these biological effects. Firstly, we found that direct cell-crystal contact was required for induction of mitogenesis as the effect was not merely a result of isotopic exchange of @entity4 into the culture medium. Treatment with @entity12 , a proton pump inhibitor, abrogated HA-induced mitogenesis to control cell levels. These results suggest that phagocytosis and intracellular crystal dissolution is required for HA-induced mitogenesis. We also demonstrated that the increase in @entity7 , previously reported, is due, at least in part, to HA-induced upregulation of @entity11 ( @entity11 ) in Hs578T cells. An accumulation of @entity10 mRNA was also shown in response to HA stimulation in Hs578T cells. Furthermore, a HA-induced increase in @entity6 ( @entity6 ), a potent inducer of @entity10 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with @entity13 (PC) (a naturally occurring inhibitor of @entity3 crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, @entity11 , @entity10 and @entity6 induction, at the transcriptional level. These results show that @entity4 HA crystals are capable of exerting significant biological effects on surrounding cells which can be abrogated by PC and emphasise the role of @entity4 HA in amplifying the pathological process involved in @entity0 .

title: @entity13 inhibits @entity5 induced mitogenesis and upregulation of @entity10 , @entity6 and @entity11 mRNA in @entity1 XXXX cell lines.

answer: @entity0


abstract: Microcalcifications containing @entity5 (HA) are often associated with malignant @entity1 breast lesions. Frequently, they are the only mammographic features that indicate the presence of a @entity2 . We previously reported the induction of both mitogenesis and @entity7 ( @entity7 ) production and the increased activities of matrix metalloproteinases (MMPs) @entity8 and @entity9 in normal @entity1 mammary epithelial cells and @entity0 cell lines, treated with HA. In the present study we attempted to elucidate the mechanism of these biological effects. Firstly, we found that direct cell-crystal contact was required for induction of mitogenesis as the effect was not merely a result of isotopic exchange of @entity4 into the culture medium. Treatment with @entity12 , a proton pump inhibitor, abrogated HA-induced mitogenesis to control cell levels. These results suggest that phagocytosis and intracellular crystal dissolution is required for HA-induced mitogenesis. We also demonstrated that the increase in @entity7 , previously reported, is due, at least in part, to HA-induced upregulation of @entity11 ( @entity11 ) in Hs578T cells. An accumulation of @entity10 mRNA was also shown in response to HA stimulation in Hs578T cells. Furthermore, a HA-induced increase in @entity6 ( @entity6 ), a potent inducer of @entity10 gene expression, was demonstrated in Hs578T cells at 2 and 4 h. Treatment with @entity13 (PC) (a naturally occurring inhibitor of @entity3 crystallisation, which is known to block a number of HA-induced biological effects in other cell types) blocked HA-mediated mitogenesis, as well as, @entity11 , @entity10 and @entity6 induction, at the transcriptional level. These results show that @entity4 HA crystals are capable of exerting significant biological effects on surrounding cells which can be abrogated by PC and emphasise the role of @entity4 HA in amplifying the pathological process involved in @entity0 .

title: @entity13 inhibits @entity5 induced mitogenesis and upregulation of @entity10 , @entity6 and @entity11 mRNA in XXXX @entity0 cell lines.

answer: @entity1


abstract: AIMS: To evaluate the results of an endoscopic follow-up assistance protocol for @entity2 ( @entity2 ) after curative surgery. @entity0 AND METHODS: Between 1994 and 1996, 205 @entity0 with @entity2 were submitted to curative surgery in our hospital. An endoscopic follow-up was proposed to the @entity0 based on an endoscopy six months following surgery, in the case they did not have a complete endoscopy prior to surgery, or one year after surgery if they did, another one two years later, and a third endoscopy between the third and fifth year. We retrospectively analyzed the follow-up outcome and endoscopic findings. RESULTS: 155 @entity0 were submitted to follow-up, of which 74,2% completed the protocol. 3 @entity1 , 4 @entity3 relapses and 2 @entity1 were detected. Curative surgery was performed on 100% of the @entity1 , 50% of the relapses and 50% of the @entity1 . 48.3% and 20.6% of the @entity0 had synchronous and @entity4 , respectively. 14.7% of the @entity4 were larger than 1 cm, 21.7% and 4.8% were tubulovillous and villous, respectively, and 3.7% had severe @entity5 . Finally, @entity0 with @entity4 had higher risk of developing @entity4 (RR 7.1, CI 95% 2.3; 22.2, p<0.0001). CONCLUSIONS: The rate of @entity6 with high risk of @entity1 or relapses detected by colonoscopy is low in our series. On the other hand, the detection of @entity4 during follow-up was related to the presence of @entity4 .

title: Endoscopic follow-up of @entity0 after curative surgery for XXXX : results of a medical assistance protocol.

answer: @entity2


abstract: AIMS: To evaluate the results of an endoscopic follow-up assistance protocol for @entity2 ( @entity2 ) after curative surgery. @entity0 AND METHODS: Between 1994 and 1996, 205 @entity0 with @entity2 were submitted to curative surgery in our hospital. An endoscopic follow-up was proposed to the @entity0 based on an endoscopy six months following surgery, in the case they did not have a complete endoscopy prior to surgery, or one year after surgery if they did, another one two years later, and a third endoscopy between the third and fifth year. We retrospectively analyzed the follow-up outcome and endoscopic findings. RESULTS: 155 @entity0 were submitted to follow-up, of which 74,2% completed the protocol. 3 @entity1 , 4 @entity3 relapses and 2 @entity1 were detected. Curative surgery was performed on 100% of the @entity1 , 50% of the relapses and 50% of the @entity1 . 48.3% and 20.6% of the @entity0 had synchronous and @entity4 , respectively. 14.7% of the @entity4 were larger than 1 cm, 21.7% and 4.8% were tubulovillous and villous, respectively, and 3.7% had severe @entity5 . Finally, @entity0 with @entity4 had higher risk of developing @entity4 (RR 7.1, CI 95% 2.3; 22.2, p<0.0001). CONCLUSIONS: The rate of @entity6 with high risk of @entity1 or relapses detected by colonoscopy is low in our series. On the other hand, the detection of @entity4 during follow-up was related to the presence of @entity4 .

title: Endoscopic follow-up of XXXX after curative surgery for @entity2 : results of a medical assistance protocol.

answer: @entity0


abstract: We tested normal young and elderly adults and elderly @entity1 ( @entity1 ) @entity0 on recognition memory for tunes. In Experiment 1, @entity1 @entity0 and age-matched controls received a study list and an old/new recognition test of highly familiar, traditional tunes, followed by a study list and test of novel tunes. The controls performed better than did the @entity1 @entity0 . The controls showed the "mirror effect" of increased hits and reduced false alarms for traditional versus novel tunes, whereas the @entity0 false-alarmed as often to traditional tunes as to novel tunes. Experiment 2 compared young adults and healthy elderly @entity0 using a similar design. Performance was lower in the elderly group, but both younger and older subjects showed the mirror effect. Experiment 3 produced confusion between preexperimental familiarity and intraexperimental familiarity by mixing traditional and novel tunes in the study lists and tests. Here, the subjects in both age groups resembled the @entity0 of Experiment 1 in failing to show the mirror effect. Older subjects again performed more poorly, and they differed qualitatively from younger subjects in setting stricter criteria for more nameable tunes. Distinguishing different sources of global familiarity is a factor in tune recognition, and the data suggest that this type of source monitoring is impaired in @entity1 and involves different strategies in younger and older adults.

title: Recognition of familiar and unfamiliar melodies in normal aging and XXXX .

answer: @entity1


abstract: The progressive increase in @entity0 with @entity8 has lengthend the waiting- list for liver transplantation. Unfortunately this has not been followed by a suitable increase in the number of donors. The expanding "donor pool" has required use of "marginal" donors (ICU stay > 10 days, sepsi; @entity2 > 30-40%, @entity7 > 155 mmol/L, inotropic drugs). We report the case of a skier who remained for more than 1 hour in @entity3 under the snow; the 49-year-old @entity0 was extracted from the snow after 1 hour and 12 minutes and found to be @entity1 , fixed @entity5 and deep @entity6 (27.2 degrees C). After cardiopulmonary resuscitation, partial cardio-respiratory activity was re-established. In the ICU severe @entity6 (26.7 degrees C) was treated with extracorporeal circulation until a re-establishment of satisfactory cardio-circulatory conditions was obtained. Unfortunately cerebral @entity4 was established and multiorgan procurement performed 3 days later. After liver transplantation into a 59 year-old @entity0 with PNC-C was performed. The course was uneventful and the @entity0 was discharged on the 19th postoperative day. CONCLUSIONS: Organ procurement from donors involved in accidental traumatic events with @entity3 and @entity6 , is similar to the non-heart-beating donor (NHBD) condition. Correct cardiopulmonary resuscitation and the use of extracorporeal circulation for gradual restoration of body temperature are necessary for optimal organ perfusion. In the present case the anoxic insult induced by the cessation of the cardio-respiratory function, was probably mitigated (if not even annulled) by the @entity6 .

title: Extreme marginal donor: severe XXXX as a rare preservation condition for explantable organs--a case report.

answer: @entity6


abstract: We report a case of primary @entity14 (PDLG) in a 76-year-old male presenting with @entity10 , @entity15 , @entity9 , @entity6 and @entity2 of recent onset. Neurological examination revealed @entity13 and bilateral sixth @entity5 . The cerebrospinal fluid showed a marked hyperproteinorachia (4711 mg/L) and mild cytorachia (5-10 leucocytes/mm3) with a few atypical lymphoid cells. On admission, brain CT scan and MRI demonstrated diffuse and nodular leptomeningeal contrast enhancement predominant at the skull base and several @entity8 in the right parietal bone. Extensive serological studies for infectious, autoimmune or @entity1 were negative. The work-up diagnosis was @entity16 or multiple meningeal and osseous metastases of an unknown primary @entity1 . Surgical biopsy of the right parietal @entity4 showed only fibrous tissue with no evidence of @entity1 or @entity3 . The @entity0 was treated with high dose @entity7 but its neurological status progressively worsened and he died of @entity11 35 days after admission. Post-mortem examination revealed a PDLG, a rare @entity1 with about 60 cases reported. PDGL is characterized by the diffusion of neoplastic glial cells throughout the leptomeninges without evidence of a primary intra-parenchymal lesion. Recognition of this rare @entity12 is important as recent reports suggest that radiotherapy and chemotherapy can improve @entity0 survival.

title: Primary XXXX : an autopsy case and review of the literature.

answer: @entity14


abstract: BACKGROUND: The @entity9 is defined as a cyst that originates by the separation of the follicle from around the crown of an unerupted tooth. The clinical examination reveals a missing tooth or teeth and possibly a @entity1 , sometimes resulting in @entity7 and possible pathologic @entity2 . A large maxillary cyst involves the whole sinus and can transmit pressure to the walls of the sinus and, consequently, cause ophthalmologic and nasal symptoms to develop. OBJECTIVES: To report the case of an extensive @entity9 with swelling of the right cheek, accompanied by @entity8 . CASE REPORT: A 21-year-old @entity0 presented with swelling of the right cheek, right-sided @entity8 , and watering of the right eye. Panoramic radiography revealed a relatively large and well-defined radiolucency enveloping an unerupted maxillary @entity3 tooth. Computed tomography scan showed a @entity6 measuring 5.2 cm horizontally, 4.3 cm vertically, and 4 cm sagittally, with expansion and erosion of the anterosinus cortical bone. The mass was seen to extend into the right half of the nasal cavity up to the right ethmoid air cells, and was in contact with the base of the skull. The bony margins of the right maxillary antrum were thinned out, the osteomeatal complex was pushed medially-superiorly, and the pterygoid plates were intact. Excision of the @entity9 of the right maxilla was performed using the Caldwell-Luc approach under general anesthesia. CONCLUSION: A @entity9 arising from an unerupted tooth should be considered in the differential diagnosis of @entity5 , and @entity4 of the gingivobuccal sulcus.

title: A case of an extensive dentigerous cyst in the maxillary sinus leading to epiphora and XXXX .

answer: @entity8


abstract: OBJECTIVE: We sought to obtain representative data on the risk factors, diagnosis, current management, and short-term outcome of neonatal @entity4 . RESEARCH DESIGN: A case registry was established at McMaster University. Standardized questionnaires were mailed to collaborators at participating centers every 4 to 6 months. SETTING: Eighty-five level III and modified level II neonatal units in North America, Europe, and Australia were invited to join the registry. @entity0 : Eligible @entity0 were born between January 1990 and June 1993. Large-vessel @entity4 was diagnosed during the first month of life or up to 44 weeks post-conception after premature birth. The clinical impression of @entity4 was confirmed using at least one imaging technique. RESULTS: Physicians in 64 centers expressed their willingness to participate. A total of 97 cases (excluding @entity2 ) were registered from 29 centers. Spontaneous @entity1 (n = 21) was diagnosed at a median age of 2 days. The other venous (n = 39), arterial (n = 33), and mixed (n = 4) @entity4 presented later; 89% of them were associated with an intravascular catheter and 29% with @entity3 . Doppler ultrasonography was the definitive diagnostic test in 68% of cases; contrast angiography was performed infrequently (14%). A third of all @entity0 (but 62% of @entity0 with @entity1 ) received supportive therapy only. Thrombolytic agents were prescribed for 28% of catheter-associated @entity5 and 30% of all arterial @entity4 . The remainder of the @entity0 were given heparin. Most @entity0 (82%) survived to hospital discharge. Mortality rates were highest among @entity0 with aortic @entity4 or central venous line-associated @entity4 affecting the right atrium or the superior vena cava (33%). CONCLUSIONS: Neonatal @entity4 is diagnosed fairly rarely. With the exception of spontaneous @entity1 , almost all cases are associated with indwelling catheters. Doppler ultrasound techniques are the most popular means of confirming the diagnosis in virtually all centers. Treatment varies greatly among different centers, probably because of the lack of scientific evidence about the optimum management of affected @entity0 .

title: Neonatal XXXX : report of a prospective Canadian and international registry.

answer: @entity4


abstract: BACKGROUND: @entity1 provoked by @entity3 agonists often go undetected in clinical series, especially if not specifically inquired about. AIM: To determine the frequency of @entity1 in a @entity2 ( @entity2 ) clinic where agonist-treated @entity0 were routinely asked about such aberrant behaviors. METHODS: We utilized the Mayo Health Science Research database to ascertain all @entity2 @entity0 taking a @entity3 agonist over a two year period (2007-2009). All were seen by a Mayo-Rochester Movement Disorders Staff specialist who routinely inquired about behavior compulsions. RESULTS: Of 321 @entity2 @entity0 taking an agonist, 69 (22%) experienced @entity1 , and 50/321 (16%) were pathologic. However, when the analysis was restricted to @entity0 taking agonist doses that were at least minimally therapeutic, pathological behaviors were documented in 24%. The subtypes were: gambling (25; 36%), hypersexuality (24; 35%), compulsive spending/shopping (18; 26%), binge eating (12; 17%), compulsive hobbying (8; 12%) and compulsive computer use (6; 9%). The vast majority of affected cases (94%) were concurrently taking carbidopa/levodopa. Among those with adequate followup, behaviors completely or partly resolved when the @entity3 agonist dose was reduced or ceased. CONCLUSIONS: @entity3 agonist treatment of @entity2 carries a substantial risk of pathological behaviors. These occurred in 16% of agonist-treated @entity0 ; however, when assessing @entity0 whose dose was at least minimally in the therapeutic range, the frequency jumped to 24%. @entity4 and hypersexuality were most common. Carbidopa/levodopa therapy taken concurrently with a @entity3 agonist appeared to be an important risk factor.

title: XXXX agonist-triggered pathological behaviors: surveillance in the @entity2 clinic reveals high frequencies.

answer: @entity3


abstract: BACKGROUND: @entity1 provoked by @entity3 agonists often go undetected in clinical series, especially if not specifically inquired about. AIM: To determine the frequency of @entity1 in a @entity2 ( @entity2 ) clinic where agonist-treated @entity0 were routinely asked about such aberrant behaviors. METHODS: We utilized the Mayo Health Science Research database to ascertain all @entity2 @entity0 taking a @entity3 agonist over a two year period (2007-2009). All were seen by a Mayo-Rochester Movement Disorders Staff specialist who routinely inquired about behavior compulsions. RESULTS: Of 321 @entity2 @entity0 taking an agonist, 69 (22%) experienced @entity1 , and 50/321 (16%) were pathologic. However, when the analysis was restricted to @entity0 taking agonist doses that were at least minimally therapeutic, pathological behaviors were documented in 24%. The subtypes were: gambling (25; 36%), hypersexuality (24; 35%), compulsive spending/shopping (18; 26%), binge eating (12; 17%), compulsive hobbying (8; 12%) and compulsive computer use (6; 9%). The vast majority of affected cases (94%) were concurrently taking carbidopa/levodopa. Among those with adequate followup, behaviors completely or partly resolved when the @entity3 agonist dose was reduced or ceased. CONCLUSIONS: @entity3 agonist treatment of @entity2 carries a substantial risk of pathological behaviors. These occurred in 16% of agonist-treated @entity0 ; however, when assessing @entity0 whose dose was at least minimally in the therapeutic range, the frequency jumped to 24%. @entity4 and hypersexuality were most common. Carbidopa/levodopa therapy taken concurrently with a @entity3 agonist appeared to be an important risk factor.

title: @entity3 agonist-triggered pathological behaviors: surveillance in the XXXX clinic reveals high frequencies.

answer: @entity2


abstract: Epithelial cells lose their usual polarization during carcinogenesis. Although most @entity0 are of epithelial origin little is known about ion channels in @entity1 cells. Previously, we observed that migration of transformed Madin-Darby @entity2 kidney (MDCK-F) cells depended on oscillating @entity3 channel activity. In the present study we examined whether periodic @entity3 channel activity may cause changes of cell volume, and whether @entity3 channel activity is distributed in a uniform way in MDCK-F cells. After determining the average volume of MDCK-F cells (2013+/-270 microm3; n=8) by means of atomic force microscopy we deduced volume changes by calculating the @entity3 efflux during bursts of @entity3 channel activity. Therefore, we measured the membrane conductance of MDCK-F cells which periodically rose by 22.3+/-2.5 nS from a resting level of 6.5+/-1.4 nS (n=12), and we measured the membrane potential which hyperpolarized in parallel from -35.4+/-1.2 mV to -71.6+/-1.8 mV (n=11). The distribution of @entity3 channel activity was assessed by locally superfusing the front or rear end of migrating MDCK-F cells with the @entity3 channel blocker charybdotoxin (CTX). Only exposure of the rear end to CTX inhibited migration providing evidence for "horizontal" polarization of @entity3 channel activity in transformed MDCK-F cells. This is in contrast to the "vertical" polarization in parent MDCK cells. We propose that the asymmetrical distribution of @entity3 channel activity is a prerequisite for migration of MDCK-F cells.

title: Polarized ion transport during migration of transformed Madin-Darby XXXX kidney cells.

answer: @entity2


abstract: Cortical @entity4 ( @entity4 ) monitoring was used in 15 @entity0 2 to 50 years old undergoing repair of @entity1 to detect the onset of @entity3 during the cross-clamp period. Three different response patterns were observed. In 8 @entity0 (53%), the @entity4 remained unchanged throughout the cross-clamping. This was designated a type 1 response. Six @entity0 (40%) showed a gradual deterioration in the @entity4 after 15 minutes of cross-clamping (type 2 response). All SEPs returned to normal levels within 5 minutes of release of the clamp. One @entity0 (7%) demonstrated a decline in @entity4 commencing prior to the application of the cross-clamp when an intercostal vessel was controlled with slings. The @entity4 completely disappeared within 5 minutes of cross-clamping, but after 19 minutes the repair was completed and the @entity4 returned within 3 minutes of reperfusion (type 3 response). No @entity0 sustained neurological sequelae of repair. We believe that @entity4 monitoring offers the potential to identify the @entity0 at risk of developing @entity3 intraoperatively before irreversible damage occurs. However, it is susceptible to deep @entity2 anesthesia, which abolishes all cortical responses and requires expert monitoring.

title: Somatosensory evoked potentials in the detection of XXXX in @entity1 repair.

answer: @entity3


abstract: Cortical @entity4 ( @entity4 ) monitoring was used in 15 @entity0 2 to 50 years old undergoing repair of @entity1 to detect the onset of @entity3 during the cross-clamp period. Three different response patterns were observed. In 8 @entity0 (53%), the @entity4 remained unchanged throughout the cross-clamping. This was designated a type 1 response. Six @entity0 (40%) showed a gradual deterioration in the @entity4 after 15 minutes of cross-clamping (type 2 response). All SEPs returned to normal levels within 5 minutes of release of the clamp. One @entity0 (7%) demonstrated a decline in @entity4 commencing prior to the application of the cross-clamp when an intercostal vessel was controlled with slings. The @entity4 completely disappeared within 5 minutes of cross-clamping, but after 19 minutes the repair was completed and the @entity4 returned within 3 minutes of reperfusion (type 3 response). No @entity0 sustained neurological sequelae of repair. We believe that @entity4 monitoring offers the potential to identify the @entity0 at risk of developing @entity3 intraoperatively before irreversible damage occurs. However, it is susceptible to deep @entity2 anesthesia, which abolishes all cortical responses and requires expert monitoring.

title: Somatosensory evoked potentials in the detection of @entity3 in XXXX repair.

answer: @entity1


abstract: Fifty-two, 8-week-old, male White Pekin ducklings ( @entity6 domesticus) were allotted into control (n = 7) and @entity5 -injected groups (n = 45). One control @entity6 and 5 to 7 @entity5 -injected (200 mg/kg of body weight) ducklings were euthanatized at postinjection hours (PIH) 1, 12, and 24 and at @entity2 ( @entity2 ) 2, 4, 7, and 14. The left ventricular myocardium was examined, using electron microscopy. The earliest ultrastructural alteration in damaged myocytes was myofibrillar lysis at PIH 12. At PIH 24, affected myocytes had @entity1 with mineralization of mitochondria. By @entity2 2, macrophages had invaded into areas of @entity3 , mineralization was prominent in myocyte mitochondria, and dedifferentiated myocytes with reduced numbers of myofibrils, increased numbers of polysomes, large nuclei, and prominent nucleoli were first observed. The primary myocardial finding at @entity2 4, 7, and 14 was 2 populations of sublethally damaged myocytes. One population of injured myocytes had numerous polysomes in the sarcoplasm and large nuclei with prominent nucleoli, indicating attempts at repair of @entity0 . The 2nd population of myocytes with myofibrillar lysis did not have morphologic evidence of myofibrillar repair. Therefore, the sequential ultrastructural alterations of damage and repair induced by @entity5 in the duckling myocardium provided model for comparative studies of @entity4 .

title: Myocardial ultrastructural alterations in ducklings with XXXX -induced cardiotoxicosis.

answer: @entity5


abstract: UNASSIGNED: Psychogenic @entity4 (PNES) often have a debilitating effect on @entity0 ' lives. @entity0 , family members, and clinicians have yet to fully understand the mechanisms and treatment of this disorder. Although reviews exist about @entity1 , there have been no systematic reviews of studies focusing on the impact of PNES. This review considers research on factors associated with the health-related quality of life (HRQoL) of @entity0 with PNES. Searches of Medline, PsycINFO, CINAHL, and Cochrane Library were conducted. Search terms identified studies that examined factors associated with HRQoL in PNES. Factors fell into three categories: (1) @entity4 and somatic factors, (2) psychological factors, and (3) coping strategies and family functioning. Fourteen articles were included. The majority of studies were cross-sectional and were of weak to moderate quality. @entity2 were negatively associated with HRQoL. Other factors associated with poorer HRQoL included dissociation, somatic symptoms, escape-avoidance coping strategies, and @entity3 . Variables such as @entity4 frequency and demographic factors were not significantly associated with HRQoL. Psychological and interpersonal factors, not @entity4 reduction, are important for the HRQoL of @entity0 with PNES. The avoidance of emotions is proposed as a perpetuating factor in the difficulties associated with poorer HRQoL. A  biopsychosocial approach has relevance for both the clinical and theoretical understanding of PNES. Larger scale research on psychological and relational factors is needed to inform therapeutic approaches to enhance HRQoL in @entity0 with PNES.

title: Correlates of health-related quality of life in adults with psychogenic XXXX : A systematic review.

answer: @entity4


abstract: @entity9 ( @entity9 ) is an autosomal, @entity1 which leads slowly to increasing subvalvular, septal and left @entity14 . Difficult molecular-genetic investigations localized genetic defects on different chromosomes. The disease is pathological-anatomically characterized by asymmetric subvalvular (aortic) @entity12 and @entity13 resulting in additional @entity8 . Histologically the myocytes are hypertrophied, exhibit atypical branching (disarray), and there is a high amount of interstitial connective tissue. In our biopsy material (from myectomies) @entity10 could be detected in more than 30% of @entity4 with partly extential media. These changes may indicate @entity2 resulting in @entity6 , @entity11 , @entity7 , and @entity3 on the basis of @entity2 and scar development. Today the discussion of DDD-pacemaker therapy has resumed, but one must wait for definite results, especially in @entity0 in whom surgical treatment seems to be the best choice. The indication for surgical treatment, which usually is transaortic subvalvular myectomy (Morrow) and modifications, is very restrictive. Only @entity0 in clinical degree III (NYHA) after long-term medical treatment are candidates for surgery. In some mainly younger @entity0 the indication in lower clinical degrees was accepted because of a family history with @entity7 and personal experience of @entity11 , life-threatening @entity5 , or after resuscitation. In the period 1963 to 1994 466 @entity0 were operated upon. The mean age was 44.9 years (range 3 months to 82 years). Total early mortality was 4.9% (n = 12).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ XXXX : surgical treatment].

answer: @entity9


abstract: Spinal microglia and astrocytes play an important role in mediating behavioral hypersensitive state following @entity4 . However, little is known about the expression patterns of activated microglia and astrocytes in the spinal dorsal horn. The aim of the present study was to investigate the spatial distribution of microglial and astrocytic activation in cervical, thoracic, lumbar and sacral segments of spinal dorsal horn following chronic @entity2 . The hind paw withdrawal threshold (PWT) of @entity3 ( @entity3 ), @entity8 (YFP) and @entity7 (YFP) @entity1 to mechanical stimulation was determined by von Frey test. Immunofluorescence staining was used to examine the spatial distribution of microglial and astrocytic activation in the spinal dorsal horn. Following CCI, all the @entity3 , @entity8 (YFP) and @entity7 (YFP) @entity1 developed robust @entity5 in the ipsilateral paw on day 3 after CCI, and the @entity5 was observed to last for 14 days. In comparison with sham groups, the PWTs of CCI group animals were significantly decreased (P < 0.01, n = 6). On day 14 after CCI, @entity8 (YFP)-GFP immunofluorescence intensity was significantly increased in the ipsilateral lumbar spinal dorsal horn of the @entity8 (YFP) @entity1 (P < 0.01, n = 6), but no detectable changes were observed in other spinal segments. Increased @entity7 (YFP)-GFP immunofluorescence intensity was observed in the ipsilateral thoracic, lumbar and sacral spinal segments of the @entity7 (YFP) @entity1 on day 14 after CCI. @entity6 and @entity7 immunofluorescence staining in @entity3 @entity1 showed the same result of microglia and astrocyte activation on day 14 after CCI. @entity8 (YFP)-GFP and @entity7 (YFP)-GFP immunofluorescence signal was colocalized with microglial marker @entity6 and astrocytic marker @entity7 , respectively. Interestingly, on day 3 after CCI, @entity6 -immunoreactivity was significantly increased in the ipsilateral thoracic, lumbar and sacral spinal segments of @entity3 @entity1 , whereas the significant upregulation of @entity7 -immunoreactivity restrictedly occurred in the ipsilateral lumbar spinal segment. These results suggest that microglial and astrocytic activation may be involved in the development and maintenance of secondary @entity5 in @entity1 with @entity0 .

title: [Activation of microglia and astrocytes in different spinal segments after XXXX in @entity1 ].

answer: @entity4


abstract: Spinal microglia and astrocytes play an important role in mediating behavioral hypersensitive state following @entity4 . However, little is known about the expression patterns of activated microglia and astrocytes in the spinal dorsal horn. The aim of the present study was to investigate the spatial distribution of microglial and astrocytic activation in cervical, thoracic, lumbar and sacral segments of spinal dorsal horn following chronic @entity2 . The hind paw withdrawal threshold (PWT) of @entity3 ( @entity3 ), @entity8 (YFP) and @entity7 (YFP) @entity1 to mechanical stimulation was determined by von Frey test. Immunofluorescence staining was used to examine the spatial distribution of microglial and astrocytic activation in the spinal dorsal horn. Following CCI, all the @entity3 , @entity8 (YFP) and @entity7 (YFP) @entity1 developed robust @entity5 in the ipsilateral paw on day 3 after CCI, and the @entity5 was observed to last for 14 days. In comparison with sham groups, the PWTs of CCI group animals were significantly decreased (P < 0.01, n = 6). On day 14 after CCI, @entity8 (YFP)-GFP immunofluorescence intensity was significantly increased in the ipsilateral lumbar spinal dorsal horn of the @entity8 (YFP) @entity1 (P < 0.01, n = 6), but no detectable changes were observed in other spinal segments. Increased @entity7 (YFP)-GFP immunofluorescence intensity was observed in the ipsilateral thoracic, lumbar and sacral spinal segments of the @entity7 (YFP) @entity1 on day 14 after CCI. @entity6 and @entity7 immunofluorescence staining in @entity3 @entity1 showed the same result of microglia and astrocyte activation on day 14 after CCI. @entity8 (YFP)-GFP and @entity7 (YFP)-GFP immunofluorescence signal was colocalized with microglial marker @entity6 and astrocytic marker @entity7 , respectively. Interestingly, on day 3 after CCI, @entity6 -immunoreactivity was significantly increased in the ipsilateral thoracic, lumbar and sacral spinal segments of @entity3 @entity1 , whereas the significant upregulation of @entity7 -immunoreactivity restrictedly occurred in the ipsilateral lumbar spinal segment. These results suggest that microglial and astrocytic activation may be involved in the development and maintenance of secondary @entity5 in @entity1 with @entity0 .

title: [Activation of microglia and astrocytes in different spinal segments after @entity4 in XXXX ].

answer: @entity1


abstract: AIM: To study the clinical manifestations and outcome of @entity0 with @entity3 treated with antituberculous therapy without concomitant use of systemic @entity1 . METHODS: We reviewed retrospectively the medical records of eight consecutive @entity0 with @entity3 . @entity0 were treated unsuccessfully with topical and/or systemic @entity1 . They underwent complete ophthalmic examination, systemic evaluation, laboratory investigations and imaging. Tuberculin skin test was done with purified protein derivative (PPD) on all @entity0 . The diagnosis of @entity3 was made based on clinical findings of @entity5 with adjacent peripheral corneal @entity4 , positive PPD test of 15   mm of induration or more, response to antituberculous treatment (ATT) within 4   weeks and exclusion of other causes of sclerokeratitis. Antituberculous drugs were given for a minimum of 6   months without concomitant use of corticosteroids. The outcome measure was resolution of the ocular surface inflammation of the sclera and @entity2 . RESULTS: Eight consecutive @entity0 with a diagnosis of @entity3 were included. There were one male and seven female @entity0 . The mean age was 29   years with an age range of 7-43   years. The involvement of the sclera was nodular in six @entity0 and diffuse in two. The involvement of the @entity2 consisted of peripheral corneal stromal inflammation adjacent to the area of @entity5 . @entity0 responded to antituberculous medications with complete resolution of the sclerokeratitis without topical or systemic anti-inflammatory agents. CONCLUSIONS: Antituberculous medications can lead to complete resolution of the sclerokeratitis without concomitant use of @entity1 , or other anti-inflammatory agents.

title: Clinical manifestations and outcome of XXXX .

answer: @entity3


abstract: BACKGROUND: @entity3 is not so recognized by clinicians as its counterparts. The efficacy of endoscopic resection has not been described yet. Our aim was to assess the efficacy and safety of endoscopic resection in the management of @entity3 . METHODS: Retrospective data were reviewed from January 2008 to December 2013 in our center. Fourteen @entity0 who had endoscopic resection with the final pathology result of @entity3 were included in the study. RESULTS: Of the 14 @entity0 , there were 12 females and two males. The median age was 59  years (range 32-83). Thirteen @entity2 (92.9  %) were from the muscularis propria and one located in the submucosa. Endoscopic en bloc resection was achieved in 12 @entity0 (12/14, 85.7  %), including seven cases of endoscopic full-thickness resection (EFTR). The mean resected @entity2 size was 1.73      1.10  cm (range 0.3-4.0  cm). In one case, endoscopic resection was suspended due to the limited experience of EFTR during the early period of the study. In another case, due to the difficult @entity2 location (gastric angle) and extraluminal growth pattern, the @entity0 was referred to laparoscopic surgery. In the 12 successful endoscopic resection cases, during the median follow-up time of 4  years (range 17-77  months, one @entity0 lost), no @entity2 residue, recurrence or @entity1 was found. CONCLUSIONS: Endoscopic resection is safe and effective in treating @entity3 with excellent long-term outcomes. However, it should be performed with caution because @entity4 is mainly located in the deep muscular layer, which leads to the full-thickness resection of gastric wall.

title: Endoscopic resection for XXXX with long-term outcomes.

answer: @entity3


abstract: This report describes a two-year-old White Alpine ram with @entity5 and a @entity3 . Prior to admission, the ram had been unsuccessfully treated with antibiotics and levamisole. Clinical examination revealed that the general behaviour and condition of the ram were severely disturbed. The rectal temperature and respiratory rate were increased. Auscultation of the lungs revealed @entity0 . Based on clinical findings, a tentative diagnosis of @entity4 was made. To confirm the diagnosis, blood was taken for serological testing for @entity6 , and endoscopic examination of the respiratory tract and ultrasonographic and radiographic examination of the thorax were performed. Cytologic and bacteriologic examination of tracheal secretions revealed large numbers of neutrophils and @entity2 organisms. A pocket of gas, surrounded by a capsule of soft tissue density, overlying the base of the heart, and a horizontal fluid line were observed on radiographs. Ultrasonographic examination revealed an effusion between the pleura and the lung on the left side of the thorax; an encapsulated @entity1 was seen on the right side of the thorax. Centesis and aspiration of this accumulation of fluid yielded foul-smelling pus. Post mortem examination confirmed the clinical, radiographic and ultrasonographic findings. The ram had severe chronic @entity5 with @entity1 formation between the pleura and lung on the right side.

title: @entity5 and a XXXX in a ram: ultrasonographic and radiographic findings.

answer: @entity3


abstract: This report describes a two-year-old White Alpine ram with @entity5 and a @entity3 . Prior to admission, the ram had been unsuccessfully treated with antibiotics and levamisole. Clinical examination revealed that the general behaviour and condition of the ram were severely disturbed. The rectal temperature and respiratory rate were increased. Auscultation of the lungs revealed @entity0 . Based on clinical findings, a tentative diagnosis of @entity4 was made. To confirm the diagnosis, blood was taken for serological testing for @entity6 , and endoscopic examination of the respiratory tract and ultrasonographic and radiographic examination of the thorax were performed. Cytologic and bacteriologic examination of tracheal secretions revealed large numbers of neutrophils and @entity2 organisms. A pocket of gas, surrounded by a capsule of soft tissue density, overlying the base of the heart, and a horizontal fluid line were observed on radiographs. Ultrasonographic examination revealed an effusion between the pleura and the lung on the left side of the thorax; an encapsulated @entity1 was seen on the right side of the thorax. Centesis and aspiration of this accumulation of fluid yielded foul-smelling pus. Post mortem examination confirmed the clinical, radiographic and ultrasonographic findings. The ram had severe chronic @entity5 with @entity1 formation between the pleura and lung on the right side.

title: XXXX and a @entity3 in a ram: ultrasonographic and radiographic findings.

answer: @entity5


abstract: @entity0 with acute exacerbations of @entity1 ( @entity1 ) are often too sick to make informed decisions regarding the use of mechanical ventilation (MV). Prior knowledge of their wishes regarding this form of therapy, therefore, is essential in order to preserve their autonomy. In order to characterize this group of @entity0 with respect to their knowledge of mechanical ventilation as a potential treatment for their disease, we surveyed 40 stable outpatients with the diagnosis of @entity1 . All @entity0 attended either the general medical clinic or the pulmonary clinic of a university and veterans' hospital. The median age of the @entity0 was 67 years, and the median forced expiratory volume in 1 second was 1.26 L. Consecutive @entity0 were asked to participate in a survey that examined the following questions: (1) Was there an awareness of MV as a treatment modality? (2) Had there been prior discussions with their physicians concerning MV? (3) Were the @entity0 able to express a decision concerning MV as indefinite life-sustaining therapy? Our results showed that 35% of @entity0 were not aware of MV. Only 14% had previously discussed MV with their physicians; 40% indicated a decision to use MV, 22% would decline MV, and 38% were unsure. @entity0 who had discussions were more likely to specify a choice concerning MV when compared with those @entity0 who had no prior discussions. We conclude that discussions between @entity0 with @entity1 and their physicians occur infrequently, but when they do occur, they help @entity0 formulate a decision.

title: Discussions with outpatients with XXXX regarding mechanical ventilation as life-sustaining therapy.

answer: @entity1


abstract: BACKGROUND: Recent studies have demonstrated differences in the intestinal microbiota between @entity0 with @entity2 ( @entity2 ) and @entity1 ( @entity1 ) suggesting a role for the intestinal microbiota in the pathogenesis of @entity2 . Alterations in the microbiota have also been implicated in the pathogenesis of abdominal bloating, a commonly reported symptom in @entity2 . We investigated the relationship between the intestinal microbiota, abdominal bloating and altered bowel patterns in a cohort of @entity0 with @entity2 and @entity1 . METHODS: The 16S rRNA gene from fresh fecal samples were amplified and pyrosequenced using Roche-454 Titanium chemistry. A Core Measurable Microbiome (CMM) was generated for Operational Taxonomic Unit (OTU) detected in >75% of all samples and compositional features of CMM were compared between groups using Linear Discriminant Analysis (LDA). KEY RESULTS: @entity2 differentiated from @entity1 by LDA using continuous variation in the species/OTUs or the CMM genera. When subcategorized based on bloating symptoms and bowel characteristics, the same subjects were also well-differentiated from one another and from @entity1 . ANOVA analysis showed quantitative species/OTUs differences between the subgroups including @entity2 with and without bloating, and subtypes based on bowel characteristics. CONCLUSIONS _ INFERENCES: The clear LDA differentiation and the significant microbial taxa differences between the groups imply a significant association of the microbiota with bloating symptoms and bowel characteristics in @entity2 . These changes in the microbiota may serve as a biomarker for @entity2 and its clinical subtypes and suggest a role for the intestinal microbiota in the pathogenesis of the main symptoms of the disorder.

title: Molecular Characterization of the Intestinal Microbiota in XXXX With and Without Abdominal Bloating.

answer: @entity0


abstract: INTRODUCTION: @entity2 after wisdom teeth surgery can be moderate in severity and is compounded by preoperative @entity1 in young @entity0 . We studied the effect of @entity6 premedication on @entity4 and preoperative @entity1 in @entity0 undergoing wisdom teeth extractions. METHODS: This randomised controlled trial recruited 76 @entity0 at Khoo @entity7 Puat Hospital who were American Society of Anesthesiologists physical status I and II, aged 21 to 65 and scheduled to undergo elective extraction of all four wisdom teeth under general anaesthesia. @entity0 with a history of long-term use or @entity5 to @entity6 were excluded. The @entity0 received either 6 mg @entity6 or a placebo 90 minutes before surgery. Visual analogue scale (VAS) scores at multiple time intervals for @entity4 and preoperative @entity1 , @entity0 satisfaction and first-night sleep quality scores were obtained. Mixed-effects regression models were used for longitudinal analysis of @entity3 , @entity1 and satisfaction scores. RESULTS: Maximum VAS scores for @entity2 and @entity1 were 18.6    19.1 mm at 60 minutes postoperatively and 26.2    23.4 mm at 90 minutes preoperatively, respectively. After adjusting for gender, female @entity0 who received @entity6 had a faster rate of reduction of @entity3 (p = 0.020) and @entity1 scores (p = 0.003) over time compared to the placebo group. No such effect was demonstrated in male @entity0 . There was no significant difference in sleep quality or satisfaction scores. CONCLUSION: @entity6 use did not consistently contribute to @entity2 and @entity1 amelioration in all @entity0 . Our study demonstrated a positive effect in female @entity0 , suggestive of sexual dimorphism.

title: XXXX premedication versus placebo in wisdom teeth extraction: a randomised controlled trial.

answer: @entity6


abstract: INTRODUCTION: @entity2 is a life-threatening clinical entity that requires emergent treatment. A variety of therapeutic methods have been applied. The purpose of this retrospective analysis was to study the efficacy of emergent surgical pericardiotomy in both the relief of @entity2 and in the prevention of recurrence of @entity3 . MATERIAL AND METHODS: This study involved 90 consecutive @entity0 (58 males and 32 females) with a mean age of 57.4    14.1 years, who underwent emergent pericardiotomy in the years 2006 to 2011 due to symptomatic primary @entity2 . At the end of the follow-up period all living subjects had control echocardiographic examination. Survival analysis was performed with the use of the Kaplan-Meier method. RESULTS: The mean duration time of surgery was 14.2    4.5 minutes. All @entity0 survived surgery but one died during in-hospital stay. During the post-discharge follow-up period (median 49 months) 32 @entity0 died for any reason. One-year and four-year probability of survival was 0.68    0.05 and 0.64    0.05, respectively. Malignancy diagnosis was associated with significant negative impact on survival. One-year and four-year probability of survival was 0.56    0.06 and 0.53    0.06 for @entity1 @entity0 while it was 0.93    0.05 and 0.89    0.06 for the others, respectively. In two cases, only @entity1 @entity0 , re-intervention due to effusion recurrence was necessary. CONCLUSIONS: Pericardiotomy, although invasive, is a safe method to relieve @entity2 . It is also very efficient in the prevention of recurrence of @entity3 , even in @entity1 @entity0 .

title: Early and long-term outcomes of pericardiotomy in the treatment of primary XXXX .

answer: @entity2


abstract: INTRODUCTION: @entity1 ( @entity1 ) is a rare (2-15%), but severe complication of cardiac surgery with overall mortality reaching 40-80%. In order to save @entity0 ' lives they are treated with renal replacement therapy (RRT). The aim of our study was to assess the impact of different perioperative factors on mortality among @entity0 treated with RRT because of @entity1 , which occurred as a complication of a heart surgery. MATERIAL AND METHODS: Retrospective analysis included 45 @entity0 , operated in the years 2009-2013, who underwent renal replacement therapy in order to treat postoperative @entity1 . The perioperative factors were analysed in two groups: group 1 - @entity0 who died before discharge; and group 2 - those who survived until hospital discharge. RESULTS: Forty-five of 3509 cardiac surgical @entity0 (1.25%) required RRT after the surgery. A total of 23 (51.11%) died before discharge (group 1). @entity0 in group 1 were characterised by older age (70.21 vs. 67 years), higher mean EuroSCORE value (9.28 vs. 7.15) (p < 0.05), higher percentage of concomitant surgery (63.63% vs. 28.57%) (p < 0.05) and of admission of @entity3 in the postoperative period (100% vs. 68.42%) (p < 0.005), and higher mean @entity2 blood level prior to RRT initiation (156.65 vs. 102.54 mg/dl) (p < 0.05). CONCLUSIONS: The statistically relevant death predictors proved to be: high EuroSCORE, concomitant surgery, and high @entity2 level at RRT initiation and admission of @entity3 in the postoperative period. After conformation in further studies, those factors may prove useful in stratification of death risk among surgical @entity0 requiring RRT.

title: Multi-factor analysis of failure of renal replacement therapy in XXXX developed after cardiac surgery.

answer: @entity1


abstract: The aim of the present study was to investigate the effects of abnormal gravity on @entity0 mesenchymal stem cells (hMSCs). Strong magnetic field and magnetic field gradient generate a magnetic force that can add to or subtract from the gravitational force. In this study, this is defined as a high-magneto-gravitational environment (HMGE). The HMGE provides three apparent gravity levels, i.e. hypogravity ( g), hypergravity (2g) and normal gravity with strong magnetic field (1g) conditions. After hMSCs were subject to HMGE for 12 h, the proliferation, morphology, structure and apoptosis were investigated. Results showed that the proliferation of hMSCs was inhibited under  g condition. The abnormal gravity induced morphologic characteristics of apoptosis cells, such as cell shrinkage, membrane blebbing, nuclear chromatin condensation and margination, decreased cell viability, and increased @entity1 /7 activity. The rate of apoptosis under  g condition is up to 56.95%. The F-actin stress fibers and microtubules were disrupted under abnormal gravity condition. Under  g-condition, the expression of @entity2 at mRNA and protein levels was up-regulated more than 9- and 6 folds, respectively. The @entity3 -a, an specific inhibitor of @entity2 , inhibited the apoptosis and prevented the disruption of cytoskeleton induced by abnormal gravity. These results implied that hMSCs were sensitive to abnormal gravity and exhibited classic apoptotic features, which might be associated with @entity2 signaling.

title: XXXX mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features.

answer: @entity0


abstract: @entity4 cause @entity2 in @entity0 . The main transmission vector is the consumption or handling of contaminated @entity1 meat, since @entity1 can be colonized asymptomatically by @entity4 . However, water has been implicated as the transmission vector in a few outbreaks. One possibility is the contamination of water effluent by @entity4 originating from @entity1 farm. The ability of @entity4 to be transmitted by water would be closely associated to its ability to survive in water. Therefore, in this study, we have evaluated the ability of reference strains and @entity1 -isolated strains to survive in water. Defined water media were used, since the composition of tap water is variable. We showed that some isolates survive better than others in defined freshwater (Fraquil) and that the survival was affected by temperature and the concentration of @entity3 . By comparing the ability of @entity4 to survive in water with other phenotypic properties previously tested, we showed that the ability to survive in water was negatively correlated with autoagglutination. Our data showed that not all @entity1 isolates have the same ability to survive in water, which is probably due to difference in genetic content.

title: Survival in water of XXXX strains isolated from the slaughterhouse.

answer: @entity4


abstract: STUDY DESIGN: We compared the sizes of the dural sac among conventional magnetic resonance imaging (MRI), axial loaded MRI, and upright myelography in @entity0 with lumbar spinal canal stenosis (LSCS). OBJECTIVE: To determine whether axial loaded MRI can demonstrate similar positional changes of the dural sac size as were detected by upright myelography in LSCS. SUMMARY OF BACKGROUND DATA: In @entity0 with LSCS, @entity1 of the dural sac is worsened and symptoms are aggravated during standing or walking. To disclose such positional changes, upright myelography has been widely used. Recently, axial loaded MRI, which can simulate a standing position, has been developed. However, there has been no study to compare the dural sac size between axial loaded MRI and upright myelography. METHODS: Forty-four @entity0 underwent conventional MRI, axial loaded MRI, and myelography. Transverse and anteroposterior diameters and the cross-sectional areas of the dural sac from L2-L3 to L5-S1 were compared. Pearson correlations of the diameters between the MRIs and the myelograms were analyzed. On the basis of the myelograms, all disc levels were divided into severe and nonsevere @entity1 groups. In each group, the diameters and the cross-sectional areas were compared. Sensitivity and specificity to detect severe @entity1 were calculated for the conventional and axial loaded MRI. RESULTS: Transverse and anteroposterior diameters at L4-L5 in the axial loaded MRI and myelogram were significantly smaller than those observed in the conventional MRI (P < 0.001). Cross-sectional areas in the axial loaded MRI were significantly smaller than those in the conventional MRI at L2-L3, L3-L4, and L4-L5 (P < 0.001). Between the axial loaded MRI and the myelography, Pearson correlation coefficients of the transverse and anteroposterior diameters were 0.85 and 0.87, respectively (P < 0.001), which were higher than those for conventional MRI. Reductions of the dural sac sizes in the axial loaded MRI were more evident in the severe @entity1 group. The axial loaded MRI detected severe @entity1 with a higher sensitivity (96.4%) and specificity (98.2%) than the conventional MRI. CONCLUSION: The axial loaded MRI demonstrated a significant reduction in the dural sac size and significant correlations of the dural sac diameters with the upright myelogram. Furthermore, the axial loaded MRI had higher sensitivity and specificity than the conventional MRI for detecting the severe @entity1 observed in the myelogram. Therefore, the axial loaded MRI can be used to represent positional changes of the dural sac size detected by the upright myelography in @entity0 with LSCS.

title: Axial loading during magnetic resonance imaging in XXXX with lumbar spinal canal stenosis: does it reproduce the positional change of the dural sac detected by upright myelography?

answer: @entity0


abstract: (Full text is available at http://www.manu.edu.mk/prilozi). @entity1 [ @entity1 ] is a @entity2 characterized by inattention, @entity4 and impulsivity that affects from 3-5% of school-aged @entity0 . In some cases it may persist into adulthood. Prominent theories about @entity1 suggest that inattention, @entity4 and impulsivity may be due to underlying @entity1 , including alerting, orienting and executive control. The aim of this study was to investigate neuropsychological characteristics of @entity1 @entity0 , especially their executive functions [EFs]. The sample is comprised of 30 @entity1 @entity0 from 6 to 14 years old [10, 45    22, 2], only @entity0 , diagnosed at the department of psychophysiology, University @entity0 's Hospital. The diagnosis was established according to ICD-10 criteria. All @entity0 had an IQ over 90 and were medication free. Psychological assessment of the @entity0 was performed with the Wechsler Intelligence Scale for @entity0 [WISC-IV] and @entity5 Comprehensive Parent Rating Scale [ASTeRS]. Neuropsychological assessment was performed with the Stroop test and the Wisconsin Card Sorting Test [WCST]. Results showed an average IQ, manifested symptoms of @entity4 and @entity3 , confirmed by the Stroop test and WCST. Key words: @entity1 , executive functions, @entity0 .

title: XXXX as an @entity3 .

answer: @entity1


abstract: (Full text is available at http://www.manu.edu.mk/prilozi). @entity1 [ @entity1 ] is a @entity2 characterized by inattention, @entity4 and impulsivity that affects from 3-5% of school-aged @entity0 . In some cases it may persist into adulthood. Prominent theories about @entity1 suggest that inattention, @entity4 and impulsivity may be due to underlying @entity1 , including alerting, orienting and executive control. The aim of this study was to investigate neuropsychological characteristics of @entity1 @entity0 , especially their executive functions [EFs]. The sample is comprised of 30 @entity1 @entity0 from 6 to 14 years old [10, 45    22, 2], only @entity0 , diagnosed at the department of psychophysiology, University @entity0 's Hospital. The diagnosis was established according to ICD-10 criteria. All @entity0 had an IQ over 90 and were medication free. Psychological assessment of the @entity0 was performed with the Wechsler Intelligence Scale for @entity0 [WISC-IV] and @entity5 Comprehensive Parent Rating Scale [ASTeRS]. Neuropsychological assessment was performed with the Stroop test and the Wisconsin Card Sorting Test [WCST]. Results showed an average IQ, manifested symptoms of @entity4 and @entity3 , confirmed by the Stroop test and WCST. Key words: @entity1 , executive functions, @entity0 .

title: @entity1 as an XXXX .

answer: @entity3


abstract: Different clinical studies have demonstrated @entity4 's efficacy in the treatment of superficial dermatomycoses when administered either @entity1 or @entity1 for four weeks. The aim of the present study was to compare both dosing schedules for the treatment of superficial dermatomycoses. In this randomized, controlled, double blind study, we included 84 @entity0 suffering superficial @entity2 (confirmed by microscopic examination (KOH) and culture) susceptible for topical monotherapy. Forty-one @entity0 received @entity4 1% @entity1 ( @entity1 ) and forty-three @entity1 ( @entity1 ) for four weeks. The efficacy of treatment was evaluated by clinical and mycological criteria at the end of treatment (D28) and after four weeks without treatment (D58). Clinical and mycological cure rates on D28 were 50% with @entity1 and 65% with @entity1 treatment. Only considering clinical evaluation, clinical cure rates on D28 were 63% ( @entity1 ) and 70% ( @entity1 ). Also, clinical and mycological cure rates on D56 were 65% with @entity1 and 72% with @entity1 treatment. Only considering clinical evaluation, clinical cure rates on D56 were of 68% ( @entity1 ) and 72% ( @entity1 ). The overall tolerability was similar in both treatment groups. The efficacy assessment at the end of treatment (D28) and four weeks after treatment discontinuation (D56) showed that the @entity1 treatment is not inferior to the @entity1 treatment, with similar clinical and mycological cure rates and clinical cure rates in both cases. The @entity1 administration of @entity4 @entity3 % is the most appropriate dosing schedule as it provides the same efficacy, it improves @entity0 's compliance and the cost per day of treatment.

title: [Comparison of the efficacy of 1% XXXX cream twice a day with 1% @entity4 cream once a day for the treatment of superficial dermatophytoses].

answer: @entity4


abstract: Different clinical studies have demonstrated @entity4 's efficacy in the treatment of superficial dermatomycoses when administered either @entity1 or @entity1 for four weeks. The aim of the present study was to compare both dosing schedules for the treatment of superficial dermatomycoses. In this randomized, controlled, double blind study, we included 84 @entity0 suffering superficial @entity2 (confirmed by microscopic examination (KOH) and culture) susceptible for topical monotherapy. Forty-one @entity0 received @entity4 1% @entity1 ( @entity1 ) and forty-three @entity1 ( @entity1 ) for four weeks. The efficacy of treatment was evaluated by clinical and mycological criteria at the end of treatment (D28) and after four weeks without treatment (D58). Clinical and mycological cure rates on D28 were 50% with @entity1 and 65% with @entity1 treatment. Only considering clinical evaluation, clinical cure rates on D28 were 63% ( @entity1 ) and 70% ( @entity1 ). Also, clinical and mycological cure rates on D56 were 65% with @entity1 and 72% with @entity1 treatment. Only considering clinical evaluation, clinical cure rates on D56 were of 68% ( @entity1 ) and 72% ( @entity1 ). The overall tolerability was similar in both treatment groups. The efficacy assessment at the end of treatment (D28) and four weeks after treatment discontinuation (D56) showed that the @entity1 treatment is not inferior to the @entity1 treatment, with similar clinical and mycological cure rates and clinical cure rates in both cases. The @entity1 administration of @entity4 @entity3 % is the most appropriate dosing schedule as it provides the same efficacy, it improves @entity0 's compliance and the cost per day of treatment.

title: [Comparison of the efficacy of 1% @entity4 cream twice a day with 1% XXXX cream once a day for the treatment of superficial dermatophytoses].

answer: @entity4


abstract: OBJECTIVE: To investigate how laymen assess the need for sickness certification and how they use the concepts "disease" and "illness" in relation to @entity1 . DESIGN: Mail questionnaire with simulated case histories. SUBJECTS: A stratified, random sample of 600 Norwegians, aged 16-69 years. MAIN OUTCOME MEASURES: Scores that measured the respondents' use of the concept "illness", and their view on need for sickness certification were constructed and analysed. RESULTS: Response rate was 54%. The respondents perceived seven case histories describing musculoskeletal health problems more often as "illness" (61%) than as "disease" (46%). There was a close correlation between the use of "illness" and assessed need for sickness certification. However, sickness certification could be suggested for cases with @entity2 , even if the @entity0 was not perceived as ill. @entity0 suggested sickness certification significantly more often than @entity0 . Age, length of education, and personal experience with serious musculoskeletal health problems influenced suggestions on certification among @entity0 . However, these variables could not explain any difference in use of the concept "illness".

title: Assessment of sickness certification and concepts of XXXX and illness in the general population.

answer: @entity1


abstract: OBJECTIVES: To determine whether ICU readmission is associated with higher severity of @entity1 scores in adult @entity0 . BACKGROUND: Readmissions to the intensive care unit (ICU) are associated with increased costs, morbidity, and mortality. METHODS: We performed searches of MEDLINE, EMBASE, and grey literature databases. We selected studies reporting data from adults who were hospitalized in an ICU, received severity of @entity1 scores, and were discharged from the ICU. Characteristics of readmitted and non-readmitted @entity0 were examined. RESULTS: We screened 4766 publications and included 31 studies in our analysis. In most studies, severity of @entity1 scores were higher in @entity0 readmitted to the ICU. Readmission was also associated with higher mortality and longer ICU and hospital stays. Excessive heterogeneity precluded the reporting of results in the form of a meta-analysis. CONCLUSIONS: ICU readmission is associated with higher severity of @entity1 scores during the same hospitalization in adult @entity0 .

title: Association of severity of XXXX and intensive care unit readmission: A systematic review.

answer: @entity1


abstract: OBJECTIVE: To study the clinicopathologic characteristics, immunophenotypes, pathologic diagnosis and differential diagnosis of @entity8 ( @entity6 ). METHODS: The clinical data, histologic features and immunohistochemical results of 6 cases of @entity8 were analyzed, with review of literature. RESULTS: There were altogether 5 @entity0 and a @entity0 . The age of @entity0 ranged from 44 to 87 years (median age = 61 years and mean age = 62 years). The sites of involvement included stomach (number = 2), jejunum (number = 2), distal ileum (number = 1) and rectum (number = 1). The @entity0 often presented with @entity4 or discomfort and tarry stool. All the cases studied showed similar morphology, were submucosa-based and composed of bland spindle cells associated with loose collagenous stroma and perivascular @entity2 . Prominent concentric fibroblastic proliferation ("onion-skin" appearance) and eosinophilic infiltrate were characteristics. Three of the @entity0 underwent surgical resection. The remaining @entity0 had the lesions removed with endoscopy. Follow-up data were available in 5 @entity0 and none of them had disease recurrence or @entity1 . CONCLUSIONS: @entity6 is a rare @entity7 . Correct diagnosis primarily relies on pathologic examination. It needs to be distinguished from @entity5 or @entity3 .

title: [Clinicopathologic features of XXXX in gastrointestinal tract].

answer: @entity6


abstract: BACKGROUND: During an epidemic of @entity1 , social networks were used for an intervention campaign. GOAL OF THIS STUDY: To characterize the epidemic and describe the yield of new cases from index-case interviews. METHODS: Analyses of morbidity data collected by the Montgomery County, Alabama, sexually transmitted disease program determined the course of the epidemic and characterized the new case yields from social networks identified via index-case interviews (partner notification investigations) and interviews with sex partners and their associates (cluster investigations). Results and costs were compared to a noncampaign period. RESULTS: The number of reported syphilis cases nearly doubled from 1990 to 1991 (201 to 348 per 100,000 residents). During the 21-week campaign, 373 case- @entity0 had partner notification/cluster investigations; 113 (11%) of 984 sex partners and 41 (3%) of 1,146 high-risk associates ( @entity0 identified during cluster investigations) had syphilis. No subgroup of case- @entity0 for which the partner notification/cluster investigation yielded more infected @entity0 than other subgroups was identified. The cost per case detected was more than twice that during a noncampaign period ( 1,627 vs.  771). CONCLUSION: Partner notification investigations yielded more infected @entity0 than cluster investigations. Further evaluation is needed to determine the role of intense partner notification/cluster investigators' efforts in the control of @entity1 .

title: Control of XXXX : the results of an intervention campaign using social networks.

answer: @entity1


abstract: BACKGROUND: Suicide has been rarely studied among @entity2 ( @entity2 ) @entity0 . The purpose of this study is to assess the frequency of suicidal thoughts, plans, and attempts among @entity2 @entity0 including the interactions among suicidal behavior, the level of social support, and satisfaction with life. @entity0 AND METHODS: The study group, of medically stable kidney recipients, including 20 @entity0 and 20 @entity0 had a mean 121.81 +/- 72.72-months follow-up for @entity2 . All @entity0 were administered a questionnaire including demographic and clinical characteristics; specific questions about psychiatry consultations, as well as questions about suicidal thoughts, plans, and attempts before and after transplantation. @entity0 responses were confirmed by chart reviews; inconsistencies were clarified with the @entity0 . Additionally, all @entity0 completed a validated Turkish version of two self-report scales, @entity3 ( @entity3 ) and Multidimensional Scale of Perceived Social Support (MSPSS). RESULTS: In total, psychiatrists assessed 19 @entity2 @entity0 , including all suicidal @entity0 . Eight @entity0 reported "suicidal thoughts-plans," including two attempts. MSPSS results revealed that a history of @entity1 consultation (P <.05) and "suicidal thoughts-plans," (P <.05) significantly correlated with lower MSPSS scores. MSPSS scores were correlated with @entity3 (P <.05). Of all @entity0 , six reported "suicidal thoughts-plans," including one suicide attempt prior to transplantation. Of six @entity0 , one was married and five were not (P <.05). Among the three @entity0 who reported suicidal thoughts-plans in the posttransplantation period, two, including one attempter, were new cases. CONCLUSIONS: High rates of suicidal thoughts-plans and attempts were found among our @entity2 @entity0 . The probability of suicidal behavior significantly increased among recipients that were single or divorced; whose satisfaction with life was decreased; and who perceived their family, friends, and significant others to be less supportive. More detailed prospective studies on suicide are needed for better care of @entity2 @entity0 .

title: Suicidal behavior, satisfaction with life, and perceived social support in XXXX .

answer: @entity2


abstract: Among 725 renal transplantations, the most common @entity3 was @entity6 , which was observed in 23 @entity0 (3.17%). The majority of 20 (6.49%) arterial stenoses appeared in our initial experiences when we routinely used end-to-end renal graft to internal iliac artery anastomoses. A significant reduction in this incidence (0.72%) was achieved by introducing end-to-side anastomoses of the renal graft artery to the external or common iliac arteries. Intractable @entity2 or @entity1 in 14 @entity0 (60.87%) with @entity6 demanded treatment. Patch angioplasty was more successful than other methods. The limited possibilities of conservative treatment of arterial @entity2 at that time were the main reason for this frequent surgical repair. Among other @entity3 , the most serious were 12 episodes of @entity4 in 10 @entity0 . Five kidneys were lost because of ruptured arterial anastomoses. In 6 @entity0 , the common or external iliac artery was ligated as to achieve hemostasis with acute @entity7 of the lower extremity in 4 @entity0 . One @entity0 required leg amputation, whereas 2 underwent extra-anatomic bypass procedures and 1 died because of @entity5 . The majority of @entity3 occurred in the initial period of our transplantation practice. However, in spite of progress in diagnostic and treatment options, @entity3 may cause considerable clinical problems.

title: XXXX after 725 kidney transplantations during 3 decades.

answer: @entity3


abstract: The incidence of @entity1 was estimated in 1055 renal transplant recipients, engrafted between 1983 and 2001 including 611 grafts from living and 444 from cadaveric donors. The meoplasms were 22 @entity4 , 18 @entity5 , 10 @entity3 nine non-Hodgkin's and one Hodgkin's lymphoma) and 24 visceral carcinomas. @entity4 were completely excised. @entity0 with @entity5 were treated by tapering the immunosuppression with cessation of @entity2 . In addition, four @entity0 received chemotherapy, and one of them received local radiotherapy. All @entity0 with @entity3 were treated by cessation of calcineurin inhibitors with modulation of the immunosuppression to levels that were safe for the graft. Furthermore, five @entity0 underwent first line chemotherapy, two @entity0 radiotherapy and two @entity0 , surgical @entity1 . The @entity0 with @entity1 were treated surgically with excision of the lesions when possible, without severe modification of the immunosuppressive regimen. Chemotherapy or radiotherapy was added accordingly. Disease-related mortality rate in @entity0 with @entity4 was 4.5%; in @entity5 cases 11.11%; in @entity3 50%; and in all the other instances, 45.8%. This study shows the increased incidence of certain @entity1 in transplant recipients, illustrating the importance of @entity1 surveillance following kidney transplantation. A substantial reduction or even cessation of immunosuppressive therapy may be necessary to achieve @entity0 survival.

title: Study of "de novo" XXXX among greek renal transplant recipients.

answer: @entity1


abstract: BACKGROUND: Studies on kidney transplantation have thus far mainly dealt with surgical techniques, immunology, and transplant tolerance. Disturbed mineral metabolism after renal denervation has not received much attention. Basic physiological research in short-term experiments has shown that experimental renal denervation in @entity0 leads to parathormone ( @entity7 )-independent @entity9 ( @entity9 ). @entity9 and other metabolic complications also have been described after clinical kidney transplantation. Furthermore, there is an unexpected increase in the risk of @entity1 . However, these studies have examined an organism pre-damaged with regard to the parathyroid and immunosuppression. Experimental investigations in syngeneic @entity0 were performed to see whether @entity9 also occurs after transplantation and thus after denervation and which target organs are involved. METHODS: Thirty-six male Lewis @entity0 subjected to laparotomy (n = 12), unilateral nephrectomy (n = 12), or unilateral transplantation and bilateral nephrectomy (n = 12) were observed for 18 weeks. RESULTS: Animals that underwent transplantation had a significant loss of @entity4 in the urine not associated with decreased @entity2 , @entity4 , or @entity5 in bone. Stability test showed no deterioration, despite a slight increase in the bone parameters of alkaline phosphatase, @entity6 , and @entity3 with unchanged calciotropic hormones. @entity8 was not observed. Parallel to @entity9 , there was a compensatory reduction in fecal @entity4 excretion. CONCLUSIONS: The loss of @entity4 after clinical kidney transplantation in the predamaged parathyroid hormone control system as well as immunosuppression and a surprising increase in the incidence of @entity1 may be explained by the denervation-related loss of @entity4 . The lack of intestinal counter-regulation could be an important pathomechanism.

title: XXXX after kidney transplantation in syngeneic @entity0 : effects on @entity8 and bone metabolism?

answer: @entity9