abstract: @entity1 continues to be a major public health problem in India in the absence of wide spread organised cervical screening programs. Visual inspection of the cervix with @entity3 (VIA) is an effective, inexpensive screening test that can be combined with simple treatment procedures for early @entity2 , provided by trained health workers. We report 7 years experience in early detection of cervical @entity1 using the VIA test in a community-based program in rural Andhra Pradesh, India where there are no existing organised cervical screening programs. MATERIALS AND METHODS: Eligible @entity0 aged between 26 and 60 were opportunistically screened by trained health wor kers using the VIA test. @entity0 who tested positive were further evaluated and those with @entity2 were treated either by cryotherapy in the screening clinic or referred to a higher center. RESULTS: A total of 18,869 @entity0 were screened by a single round of VIA testing with a positive rate of 10.75%. Biopsy proven high-grade squamous intraepithelials (HSILs) were 90 (0.48%) and low-grade squamous intraepithelials (LSILs) were 43 (0.28%). The overall prevalence of @entity4 ( @entity4 ) 2+ lesion rate is 1.05%. A total of 312 (1.65%) cryotherapies were done and 49 @entity0 underwent hysterectomy. CONCLUSIONS: VIA by trained female health workers is a safe, acceptable, and effective test that can save lives from cervical @entity1 even in remote areas with few resources. These results have important implications for efficient service delivery in cervical screening programs in low-resourced settings.

title: Visual Inspection with XXXX (VIA) Screening Program: 7 Years Experience in Early Detection of Cervical @entity1 in Rural South India.

answer: @entity3


abstract: @entity1 continues to be a major public health problem in India in the absence of wide spread organised cervical screening programs. Visual inspection of the cervix with @entity3 (VIA) is an effective, inexpensive screening test that can be combined with simple treatment procedures for early @entity2 , provided by trained health workers. We report 7 years experience in early detection of cervical @entity1 using the VIA test in a community-based program in rural Andhra Pradesh, India where there are no existing organised cervical screening programs. MATERIALS AND METHODS: Eligible @entity0 aged between 26 and 60 were opportunistically screened by trained health wor kers using the VIA test. @entity0 who tested positive were further evaluated and those with @entity2 were treated either by cryotherapy in the screening clinic or referred to a higher center. RESULTS: A total of 18,869 @entity0 were screened by a single round of VIA testing with a positive rate of 10.75%. Biopsy proven high-grade squamous intraepithelials (HSILs) were 90 (0.48%) and low-grade squamous intraepithelials (LSILs) were 43 (0.28%). The overall prevalence of @entity4 ( @entity4 ) 2+ lesion rate is 1.05%. A total of 312 (1.65%) cryotherapies were done and 49 @entity0 underwent hysterectomy. CONCLUSIONS: VIA by trained female health workers is a safe, acceptable, and effective test that can save lives from cervical @entity1 even in remote areas with few resources. These results have important implications for efficient service delivery in cervical screening programs in low-resourced settings.

title: Visual Inspection with @entity3 (VIA) Screening Program: 7 Years Experience in Early Detection of Cervical XXXX in Rural South India.

answer: @entity1


abstract: UNASSIGNED: Genetic testing for cardiac @entity9 in @entity6 ( @entity6 ) has developed substantially over the last years. The Next Generation Sequencing (NGS) technology provides an unprecedented opportunity to screen for genetic variations underlying arrhythmogenic genes in a short period of time at a low cost. The present study aimed to perform genetic testing with NGS technologies on the Ion Torrent Personal Genome Machine    (Ion @entity11   ) sequencer, in targeting a total of 23 genes reported to be associated with @entity3 in order to identify the possible cause of @entity2 in a cohort of post-mortem cases. The molecular analyses focused on 16 cases of @entity6 , aged less than 35 years old. In all cases, the cause of @entity2 could not be determined after a rigorous autopsy associated with histopathological and toxicological analyses according to the guidelines of the Association for European @entity0 . DNA was extracted from fresh frozen tissue. An average of 200 variants was identified per case. However, after the prioritization process using a new scoring program (VaRank) and after the conjunction of clinical data and molecular findings, four "likely pathogenic" variants (including two undescribed variants), were identified in three cases (18.75%) of our cohort in the genes @entity8 , @entity4 , @entity7 and @entity10 . One case, who died during @entity1 hospitalization after administration of a QT prolonging drug, showed a double "likely pathogenic" variant in Long QT genes ( @entity4 and @entity7 ) which may have predisposed to drug-induced @entity5 . Our study illustrates that the NGS approach based on AmpliSeq    libraries and Ion Torrent PGM    sequencing may be an efficient approach, integrated to post-mortem examination. Given the massive amount of information generated by NGS, a rigorous filtration strategy of variants coupled with multidisciplinary collaboration is crucial to determine the potential pathogenic role of identified variants in the cause of @entity2 .

title: Targeted next generation sequencing application in cardiac XXXX : Analysis of a cohort of autopsy-negative sudden unexplained deaths.

answer: @entity9


abstract: BACKGROUND: Variable results associated with fat grafting have been attributed to local @entity3 , inconsistencies in transfer, and @entity1 before the development of recipient circulation. Remote @entity1 preconditioning is an inexpensive noninvasive technique that has been used in animal models and multicenter clinical trials to protect organ systems. In this work, the authors describe a novel animal model for analyzing the efficacy of fat grafting, and investigate the effect of remote @entity1 preconditioning on volume retention. METHODS: Subcutaneous adipose tissue samples from green fluorescent protein/luciferase-expressing FVB @entity0 were obtained with or without pretreatment with a temporary hind-limb tourniquet. The samples were injected into the dorsal skin folds of wild-type FVB @entity0 . The viability of the transferred tissue was examined over a 28-day period with quantitative bioluminescence after @entity4 injection. Transferred tissue was also explanted for histologic analysis. RESULTS: The remote @entity1 preconditioning group had significantly increased bioluminescence at days 0, 1, and 28. Histologic analysis at day 28 confirmed the presence of vascularized adipose in both groups. However, significant amounts of @entity2 were found in the control group, whereas substantially less was found in the remote @entity1 preconditioning group. The remote @entity1 preconditioning group retained a substantially greater amount of green fluorescent protein, suggesting increased survival of donor adipocytes. CONCLUSIONS: In this work, the authors describe a novel animal model for quantitative evaluation of fat grafting using in vivo bioluminescence of adipocytes from luciferase-expressing @entity0 . The authors also demonstrate that remote @entity1 preconditioning increases the viability of fat transfer and decreases @entity2 .

title: Remote Ischemic Preconditioning Improves the Viability of Donor Lipoaspirate during XXXX Fat Transfer.

answer: @entity0


abstract: BACKGROUND: About 25% of @entity1 strokes are categorized as cryptogenic (i.e. of unknown cause), but few data exist about the extent of diagnostic testing or treatment. We undertook an international survey to characterize current diagnostic evaluation and antithrombotic management of @entity0 with cryptogenic @entity3 in 2014. AIMS/HYPOTHESIS: To determine the type of diagnostic evaluation undertaken for cryptogenic @entity3 and antithrombotic management and to compare across global regions. METHODS: An 18-question online survey was sent to 995 physicians involved in @entity2 care in 61 countries. Countries were separated into World Bank global regions and income groups. Diagnostic tests were considered routine if performed in >75% of @entity0 at a center. RESULTS: Three hundred one completed surveys were received from 48 countries (response rate    30%). The majority (82%) of hospitals were from high-income countries and mainly from Europe and Central Asia (56%) and North America (19%). For @entity3 @entity0 , magnetic resonance imaging is routinely obtained at 36% of hospitals (highest in North America, 58%). Among cryptogenic @entity2 @entity0 , transesophageal echocardiography is routinely performed in 17% of hospitals. More than 24   hour cardiac rhythm monitoring is done routinely at relatively few (17%) hospitals (highest in North America, 33%). Intracranial arterial imaging is done routinely at 70% of hospitals, with no significant regional differences. Antiplatelet therapies are routinely prescribed for secondary prevention at 94% of hospitals. CONCLUSIONS: Based on self-selected respondents from a large number of international @entity2 centers, transesophageal echocardiography and prolonged (>24   h) cardiac rhythm monitoring are not routinely performed in cryptogenic @entity2 @entity0 , even in high-income countries. Antiplatelet therapy is the global standard for secondary prevention of cryptogenic @entity2 .

title: Global survey of the diagnostic evaluation and management of cryptogenic XXXX .

answer: @entity3


abstract: OBJECTIVE: To compare audiometric and functional outcomes between two designs of heat-activated self-crimping stapes prostheses-a modified shape memory circumferential @entity1 -Teflon piston versus its predecessor-in @entity0 with @entity2 . STUDY DESIGN: A retrospective analysis of preoperative and postoperative hearing thresholds. SETTING: Tertiary referral center and teaching hospital. @entity0 : One hundred sixty-three consecutive procedures of primary stapes surgery for clinically proven @entity2 in 108 @entity0 and 55 @entity0 with an average age of 46 years. INTERVENTION: Stapedotomy and insertion of either a standard or a circumferential stapes prosthesis. MAIN OUTCOME MEASURES: Four-frequency pure-tone average preoperative and postoperative air-bone thresholds were recorded. A secondary outcome measure was stability of the implant, as measured by failure rates. RESULTS: Success of closure of the air-bone gap to within 10 dB was achieved in 97% and comparable in both groups (original prosthesis, 23.6; standard deviation, 7.3, with the average reduction seen in the circumferential prosthesis group being 22.6, standard deviation, 5.6). All the differences were not statistically significant using two-way analysis of variance. Failure rate for the original piston was 6%, with no failures seen with the circumferential piston. CONCLUSION: Both prostheses showed comparable postoperative hearing outcomes, with the circumferential prosthesis being found to be more stable.

title: Comparison of Audiometric and Functional Outcomes Between the Standard and Modified 360 XXXX Shape Memory Stapes Prostheses.

answer: @entity1


abstract: UNASSIGNED: We retrospectively reviewed @entity0 charts to compare the approach-related (convex versus concave) @entity1 and magnitude of correction in @entity0 undergoing lateral lumbar interbody fusion (LLIF). It is yet to be quantitatively determined if correction of adult @entity2 from either side of the curve apex using a LLIF results in a reduction in complications and/or improved corrective ability. The inclusion criteria for this study were @entity0 who underwent a LLIF for adult @entity2 and had the LLIF prior to any other supplemental procedures. @entity0 were grouped based on the approach toward the curve apex concavity (CAVE) or the convexity (VEX). Standard coronal and sagittal radiographic measurements were made. @entity1 and reoperation indications were also recorded. We included 32 @entity0 for review (CAVE: 17; VEX: 15) with a mean age of 65.5 years  a standard deviation of 10.2, and mean follow-up of 17.0months  15.7. There were eight postoperative @entity1 in eight @entity0 (25.0%), and seven reoperations for six @entity0 (18.8%; CAVE: 4/17 [23.5%]; VEX: 2/15 [13.3%]). The CAVE group had 6/17 @entity1 (35.3%; four ipsilateral and two contralateral to approach side) and VEX had 2/15 (13.3%; one ipsilateral and one bilateral to approach side; p>0.05). All @entity0 significantly improved in the mean regional and segmental Cobb angles (p<0.05), except for T11-T12 (p>0.05). There were no significant differences between the groups for any of the radiographic parameters measured (p>0.05). Approaching the curve apex from either the concave or convex side resulted in significant improvements. The concave approach was associated with more postoperative @entity1 .

title: The concave versus convex approach for minimally invasive lateral lumbar interbody fusion for thoracolumbar XXXX .

answer: @entity2


abstract: INTRODUCTION AND HYPOTHESIS: A relationship between @entity1 and @entity3 of the urethrovesical junction (UVJ) during pregnancy has been described. The aim of the study was to compare the effects of @entity2 ( @entity2 ) and caesarean section (CS) on UVJ mobility. METHODS: The retrovesical angle (RVA) and the anterior angle between the UVJ and the pubic bone, the pubovesical angle (PVA), were evaluated ultrasonographically in controls and pregnant @entity0 during their first pregnancy between 38 and 40 weeks, and then re-evaluated 6 weeks and 6 months after delivery. All @entity0 completed a validated questionnaire (ICIQ-SF). Differences between and within groups were assessed with Student's t test, the chi-squared test for trend, and one-way two-tailed analysis of variance with Scheff  's post-hoc test. The correlation between PVA and RVA was evaluated using the Spearman R correlation. The positive predictive value, negative predictive value, sensitivity and specificity for the prediction of stress @entity1 (SUI) symptoms were also determined. RESULTS: Included in the study were 42 controls and 217 pregnant @entity0 . PVA at rest, during cough and Valsalva manoeuvre was significantly higher in pregnant @entity0 than in controls and in @entity0 6 weeks after @entity2 in comparison with @entity0 who had undergone CS. @entity0 affected by SUI showed a significantly higher PVA. RVA did not differ between subjects affected or not by SUI symptoms. PVA and RVA were not correlated with each other. CONCLUSIONS: PVA and RVA are increased in pregnant @entity0 in comparison with controls. In @entity0 undergoing @entity2 , PVA is restored significantly later than in those undergoing CS. The change in RVA after pregnancy and delivery seems to persist longer than the change in PVA.

title: Ultrasonographic evaluation of urethrovesical junction mobility: correlation with type of delivery and stress XXXX .

answer: @entity1


abstract: AIMS: Our study aimed to examine the association between early life stress and early initiation of @entity1 and @entity2 use. DESIGN: This prospective cohort study of @entity0 and @entity0 belongs to the Ukrainian component of the European Longitudinal Study of Pregnancy and Childhood. SETTING: Dniprodzerzhynsk, a city of some 250,000 inhabitants in south central Ukraine. @entity0 : All 4398 @entity0 who visited antenatal clinics between December 25, 1992 and July 23, 1994, planned to continue their pregnancy, and were permanent residents of the city were invited to participate. Of the 4398 invitees, 2148 agreed and 1020 of the mother- @entity0 pairs were available for complete follow-up until the @entity0 were 16years old. MEASUREMENTS: When study @entity0 reached ages 3 and 7, their mothers completed questionnaires about their @entity0 's exposure to and impact from a standard list of recent stressful life events. From the data on event prevalence and severity, we assigned each @entity0 to low, medium, or high early life stress. When the @entity0 became age 16, they completed questionnaires about their history of smoking and drinking. FINDINGS: In multivariate analysis that controlled for current level of family income, current family type, current school type, year of @entity0 's birth, lifetime smoking and current drinking by mother, and education of mother and father, @entity0 with high stress at age 3 had 2.2 times (95% confidence interval: 1.23-4.08) higher odds than @entity0 with low stress to start smoking early. CONCLUSIONS: Our study may be the first to use a longitudinal study design to examine early life stress as a risk factor for early smoking initiation in adolescence.

title: The impact of early life stress on risk of XXXX smoking initiation by adolescents.

answer: @entity2


abstract: In our earlier investigations it has been shown that the gastrointestinal (GI) tract of the @entity0 @entity1 (4-5 days old) can be colonized following a single intragastric challenge with @entity4 . This makes it possible to investigate the sequence of events which occur during colonization of the GI tract by this opportunistic @entity2 . Two strains of @entity4 , CA 30 and NS 33, which were shown in earlier studies to differ markedly in their ability to persist in the GI tract were examined. The SEM was used to reveal the location of the @entity2 and their structural association with the surface of tissues of the gut at early times after intragastric inoculation. Animals were sacrificed after challenge, the GI tract was removed from each @entity1 and subdivided into the stomach, upper intestine, mid-intestine, ileum, cecum and large bowel. The number of colony forming units was determined by homogenizing these segments and plating them out on sabouraud's dextrose agar. The microenvironment of each segment was preserved by freezing samples in liquid @entity3 prior to processing for the SEM. The distribution and level of counts of the strains studied in the GI tract were comparable during the three week period. Both strains of @entity4 associated with the secreting epithelium and the keratinized epithelium of the stomach. @entity2 also associated with the mucus layer and the epithelial surface throughout the GI tract. Those @entity2 adhering to the epithelial surfaces of the GI tract were frequently covered by a layer of mucus which may aid in colonization.

title: SEM studies of adherence of @entity4 to the gastrointestinal tract of @entity0 XXXX .

answer: @entity1


abstract: In our earlier investigations it has been shown that the gastrointestinal (GI) tract of the @entity0 @entity1 (4-5 days old) can be colonized following a single intragastric challenge with @entity4 . This makes it possible to investigate the sequence of events which occur during colonization of the GI tract by this opportunistic @entity2 . Two strains of @entity4 , CA 30 and NS 33, which were shown in earlier studies to differ markedly in their ability to persist in the GI tract were examined. The SEM was used to reveal the location of the @entity2 and their structural association with the surface of tissues of the gut at early times after intragastric inoculation. Animals were sacrificed after challenge, the GI tract was removed from each @entity1 and subdivided into the stomach, upper intestine, mid-intestine, ileum, cecum and large bowel. The number of colony forming units was determined by homogenizing these segments and plating them out on sabouraud's dextrose agar. The microenvironment of each segment was preserved by freezing samples in liquid @entity3 prior to processing for the SEM. The distribution and level of counts of the strains studied in the GI tract were comparable during the three week period. Both strains of @entity4 associated with the secreting epithelium and the keratinized epithelium of the stomach. @entity2 also associated with the mucus layer and the epithelial surface throughout the GI tract. Those @entity2 adhering to the epithelial surfaces of the GI tract were frequently covered by a layer of mucus which may aid in colonization.

title: SEM studies of adherence of XXXX to the gastrointestinal tract of @entity0 @entity1 .

answer: @entity4


abstract: In our earlier investigations it has been shown that the gastrointestinal (GI) tract of the @entity0 @entity1 (4-5 days old) can be colonized following a single intragastric challenge with @entity4 . This makes it possible to investigate the sequence of events which occur during colonization of the GI tract by this opportunistic @entity2 . Two strains of @entity4 , CA 30 and NS 33, which were shown in earlier studies to differ markedly in their ability to persist in the GI tract were examined. The SEM was used to reveal the location of the @entity2 and their structural association with the surface of tissues of the gut at early times after intragastric inoculation. Animals were sacrificed after challenge, the GI tract was removed from each @entity1 and subdivided into the stomach, upper intestine, mid-intestine, ileum, cecum and large bowel. The number of colony forming units was determined by homogenizing these segments and plating them out on sabouraud's dextrose agar. The microenvironment of each segment was preserved by freezing samples in liquid @entity3 prior to processing for the SEM. The distribution and level of counts of the strains studied in the GI tract were comparable during the three week period. Both strains of @entity4 associated with the secreting epithelium and the keratinized epithelium of the stomach. @entity2 also associated with the mucus layer and the epithelial surface throughout the GI tract. Those @entity2 adhering to the epithelial surfaces of the GI tract were frequently covered by a layer of mucus which may aid in colonization.

title: SEM studies of adherence of @entity4 to the gastrointestinal tract of XXXX @entity1 .

answer: @entity0


abstract: OBJECTIVES: The physical and chemical stability of a preservative-free oral solution of @entity3 was studied at different pH values and storage temperatures. METHODS: Oral solutions of @entity1 1 mg/mL were prepared by dissolving @entity3 powder in @entity2 buffers at pH 4.0, 5.5, and 6.5, or with sterile water (pH 7.4) stored in amber glass vials. Three identical samples of the formulations were prepared and stored under refrigeration (3-7  C), ambient temperature (20-22  C) and high temperature (29-31  C). A 200- L sample was withdrawn from each of the 3 samples immediately after preparation and at 1, 7, 14, 21, and 35 days. Samples were assayed in duplicate using stability-indicating liquid chromatography. Stability was determined by evaluating the percentage of the initial concentration remaining at each time point; stability was defined as the retention of at least 90% of the initial concentration of @entity3 . RESULTS: At least 92% of the initial @entity3 concentration in solutions pH 5.5, 6.5, and 7.4 remained throughout the 14-day study period under refrigeration. There were no detectable changes in color, odor, or pH and no visible microbial growth in these samples. In other storage conditions, @entity3 was rapidly degraded. CONCLUSIONS: The @entity3 preservative-free oral solutions at pH 5.5, 6.5, or 7.4 are chemically stable when stored under refrigeration for at least 14 days. They provide flexible and convenient dosage forms without any preservatives for pediatric @entity0 .

title: Stability of XXXX Preservative-Free Oral Solutions.

answer: @entity1


abstract: Gender disparities in short- and long-term outcomes have been documented in cardiac and valvular heart surgery. However, there is a paucity of data regarding these differences in the @entity2 ( @entity2 ) population. The aim of this study was to examine gender-specific differences in short- and long-term outcomes after surgical aortic valve (AV) replacement in @entity0 with @entity2 . A retrospective analysis was performed in 628 consecutive @entity0 with @entity2 who underwent AV surgery from April 2004 to December 2013. To reduce bias when comparing outcomes by gender, propensity score matching obtained on the basis of potential confounders was used. @entity0 with @entity2 who underwent AV surgery presented with more advanced age (mean 60.7    13.8 vs 56.3    13.6 years, p <0.001) and less @entity1 (29% vs 44%, p <0.001) and had a higher risk for in-hospital mortality (mean Ambler score 3.4    4.4 vs 2.5    4.0, p = 0.015). After propensity score matching, @entity0 received more blood products postoperatively (48% vs 34%, p = 0.028) and had more prolonged postoperative lengths of stay (median 5 days [interquartile range 5 to 7] vs 5 days [interquartile range 4 to 6], p = 0.027). Operative, discharge, and 30-day mortality and overall survival were not significantly different. In conclusion, @entity0 with @entity2 who underwent AV surgery were older, presented with less @entity1 , and had increased co-morbidities, lending higher operative risk. Although @entity0 received more blood products and had significantly longer lengths of stay, short- and long-term outcomes were similar.

title: Comparison of outcomes and presentation in XXXX -versus- @entity0 with bicuspid aortic valves undergoing aortic valve replacement.

answer: @entity0


abstract: Gender disparities in short- and long-term outcomes have been documented in cardiac and valvular heart surgery. However, there is a paucity of data regarding these differences in the @entity2 ( @entity2 ) population. The aim of this study was to examine gender-specific differences in short- and long-term outcomes after surgical aortic valve (AV) replacement in @entity0 with @entity2 . A retrospective analysis was performed in 628 consecutive @entity0 with @entity2 who underwent AV surgery from April 2004 to December 2013. To reduce bias when comparing outcomes by gender, propensity score matching obtained on the basis of potential confounders was used. @entity0 with @entity2 who underwent AV surgery presented with more advanced age (mean 60.7    13.8 vs 56.3    13.6 years, p <0.001) and less @entity1 (29% vs 44%, p <0.001) and had a higher risk for in-hospital mortality (mean Ambler score 3.4    4.4 vs 2.5    4.0, p = 0.015). After propensity score matching, @entity0 received more blood products postoperatively (48% vs 34%, p = 0.028) and had more prolonged postoperative lengths of stay (median 5 days [interquartile range 5 to 7] vs 5 days [interquartile range 4 to 6], p = 0.027). Operative, discharge, and 30-day mortality and overall survival were not significantly different. In conclusion, @entity0 with @entity2 who underwent AV surgery were older, presented with less @entity1 , and had increased co-morbidities, lending higher operative risk. Although @entity0 received more blood products and had significantly longer lengths of stay, short- and long-term outcomes were similar.

title: Comparison of outcomes and presentation in @entity0 -versus- XXXX with bicuspid aortic valves undergoing aortic valve replacement.

answer: @entity0


abstract: INTRODUCTION: The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known. MATERIAL AND METHODS: This study included 47 @entity0 with @entity3 (22 @entity0 with @entity5 and 25 @entity0 with @entity4 ) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity @entity6 (hs-CRP) and @entity2 ( @entity2 ) were measured. The OCT can detect thin-cap @entity7 (TCFA), a lesion with high potential for adverse @entity1 . We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers. RESULTS: We observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and @entity2 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and @entity2 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log @entity2 was an independent predictor for TCFA detected by OCT (log @entity2 , 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that @entity2 , compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively). CONCLUSIONS: Peripheral blood levels of both hs-CRP and @entity2 were associated with TCFAs, as detected by OCT. Moreover, @entity2 has a higher potential than hs-CRP for predicting TCFA.

title: Association between inflammatory biomarkers and thin-cap XXXX detected by optical coherence tomography in @entity0 with coronary heart disease.

answer: @entity7


abstract: INTRODUCTION: The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known. MATERIAL AND METHODS: This study included 47 @entity0 with @entity3 (22 @entity0 with @entity5 and 25 @entity0 with @entity4 ) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity @entity6 (hs-CRP) and @entity2 ( @entity2 ) were measured. The OCT can detect thin-cap @entity7 (TCFA), a lesion with high potential for adverse @entity1 . We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers. RESULTS: We observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and @entity2 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and @entity2 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log @entity2 was an independent predictor for TCFA detected by OCT (log @entity2 , 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that @entity2 , compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively). CONCLUSIONS: Peripheral blood levels of both hs-CRP and @entity2 were associated with TCFAs, as detected by OCT. Moreover, @entity2 has a higher potential than hs-CRP for predicting TCFA.

title: Association between inflammatory biomarkers and thin-cap @entity7 detected by optical coherence tomography in XXXX with coronary heart disease.

answer: @entity0


abstract: BACKGROUND: This study assessed the efficacy and safety of briakinumab, a human anti-IL-12/23p40 monoclonal antibody, compared with placebo for the induction and maintenance of remission in @entity0 with moderately to severely active @entity2 . METHODS: In this phase 2b, multicenter, double-blind, parallel group study, 246 @entity0 stratified by prior @entity1 necrosis factor-antagonist use and response, were randomized (1:1:1:3) to 4 intravenous induction regimens: placebo, 200, 400, or 700 mg briakinumab, at weeks 0/4/8. At week 12, responders in the placebo or 400-mg induction groups entered the maintenance phase with the same regimen, whereas responders in the 700-mg induction group were rerandomized (1:1:1) to receive placebo, 200, or 700 mg briakinumab at weeks 12/16/20. At week 24, @entity0 in remission stopped receiving study drug (withdrawal phase) until relapse. @entity0 experiencing relapse, nonresponders, and nonremitters could enter the open-label phase. RESULTS: The primary end point of clinical remission at week 6 was not met. There were numerically greater rates of remission and response at 6, 12, or 24 weeks in @entity0 treated with briakinumab. The safety and tolerability profile of briakinumab was similar in the induction and maintenance phases of the trial. CONCLUSIONS: Briakinumab showed a similar safety and tolerability profile to placebo in the induction and maintenance phases, and comparable rates of serious adverse events, adverse events leading to discontinuation, and @entity1 . These data provide support for the potential efficacy of briakinumab and other IL-12/23 inhibitors in the treatment of moderate-to-severe @entity2 .

title: Briakinumab for treatment of XXXX : results of a randomized trial.

answer: @entity2


abstract: UNASSIGNED: In vitro differentiation of @entity0 embryonic stem cells (hESCs) into endometrium-like cells may provide a useful tool for clinical treatment. The aim of the present study was to investigate the differentiation potential of hESCs into endometrium-like cells using three methods, which included induction by feeder cells, co-culture with endometrial stromal cells and induction with embryoid bodies. Following differentiation, the majority of cells positively expressed cytokeratin and @entity3 ( @entity3 ). Factors associated with endometrium cell function, namely the @entity1 and @entity2 receptors (ER and PR), were also detected. At day 21 following the induction of differentiation, the expression levels of cytokeratin, @entity3 , ER and PR were significantly increased in the co-culture method group, as compared with the other two methods. Furthermore, these cells became decidualized in response to @entity2 and prolactin. In addition, the number of cytokeratin-positive or @entity3 -positive cells significantly increased following the induction of differentiation using the co-culture method, as compared with the other two methods. The mRNA expression levels of Wnt members that are associated with endometrial development were subsequently examined, and @entity5 was found to be significantly upregulated in the differentiated cells induced by feeder cells and co-culture with endometrial stromal cells; however, @entity4 and @entity6 expression levels were unaffected. Additionally, the mRNA expression levels of @entity5 in the differentiated cells co-cultured with endometrial stromal cells were higher when compared with those induced by feeder cells. In conclusion, the present findings indicated that the co-culture system is the optimal protocol for the induction of hESC differentiation into endometrium-like cells, and @entity5 signaling may be involved in this process.

title: Co-culture with endometrial stromal cells enhances the differentiation of XXXX embryonic stem cells into endometrium-like cells.

answer: @entity0


abstract: PURPOSE: Cognitive effort is a clinically important facet of linguistic processing that is often overlooked in the assessment and treatment of @entity0 with @entity1 (PWA). Furthermore, there is a paucity of valid ways to index cognitive effort in PWA. The construct of cognitive effort has been indexed for decades via pupillometry (measurement of pupil dilation and @entity2 during a cognitive task), yet pupillometry has not been implemented in studies including PWA. In the present study, we tested a novel method for indexing cognitive effort during linguistic processing in @entity0 with and without @entity1 . METHOD: Forty control @entity0 and 39 PWA listened to semantically easy and difficult single nouns and looked at images while their pupillary responses were monitored. Mean pupil dilation in response to easy versus difficult nouns was calculated to index cognitive effort. RESULTS: Larger mean pupil dilation values were obtained for difficult compared with easy nouns for both groups. CONCLUSION: Results provide preliminary evidence that pupillometry can be used to index cognitive effort during linguistic processing of single nouns in @entity0 with and without @entity1 . Methods for indexing cognitive effort will be a valuable addition to existing assessment methods. Suggestions for further research are offered.

title: A Novel Pupillometric Method for Indexing Word Difficulty in Individuals With and Without XXXX .

answer: @entity1


abstract: AIM: The present study investigated the effects of @entity4 ( @entity4 ), @entity3 ( @entity3 ), @entity5 ( @entity5 ) and @entity6 ( @entity6 )/exon-3 polymorphism on @entity1 ( @entity1 ) and @entity2 ( @entity2 ) @entity0 . @entity0 AND METHODS: Ninety @entity0 with @entity2 , 90 @entity0 with @entity1 and 96 controls were included in this study. The @entity4 , @entity3 and @entity5 serum levels were measured with enzyme-linked immunosorbent assay. @entity6 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity6 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity4 , @entity3 and @entity5 were not distributed according to @entity6 /exon-3 variants. However, in the @entity1 group, higher levels of @entity3 and lower levels of @entity4 and @entity5 , and in @entity2 group lower levels of @entity3 , @entity4 and @entity5 were observed. The order of @entity4 levels were @entity1 < @entity2 < Controls; @entity3 levels were @entity2 <Controls< @entity1 and @entity5 levels were @entity2 < @entity1 <Controls. CONCLUSION: No direct effect of @entity6 /exon-3 polymorphism was observed in @entity1 or @entity2 @entity0 . However @entity4 , @entity3 , @entity5 and insulin were thought to act together to establish body homeostasis in @entity0 with @entity1 and @entity2 .

title: The Effect of @entity6 /exon-3 Polymorphism and Serum @entity4 , @entity3 and XXXX Levels in @entity2 .

answer: @entity5


abstract: AIM: The present study investigated the effects of @entity4 ( @entity4 ), @entity3 ( @entity3 ), @entity5 ( @entity5 ) and @entity6 ( @entity6 )/exon-3 polymorphism on @entity1 ( @entity1 ) and @entity2 ( @entity2 ) @entity0 . @entity0 AND METHODS: Ninety @entity0 with @entity2 , 90 @entity0 with @entity1 and 96 controls were included in this study. The @entity4 , @entity3 and @entity5 serum levels were measured with enzyme-linked immunosorbent assay. @entity6 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity6 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity4 , @entity3 and @entity5 were not distributed according to @entity6 /exon-3 variants. However, in the @entity1 group, higher levels of @entity3 and lower levels of @entity4 and @entity5 , and in @entity2 group lower levels of @entity3 , @entity4 and @entity5 were observed. The order of @entity4 levels were @entity1 < @entity2 < Controls; @entity3 levels were @entity2 <Controls< @entity1 and @entity5 levels were @entity2 < @entity1 <Controls. CONCLUSION: No direct effect of @entity6 /exon-3 polymorphism was observed in @entity1 or @entity2 @entity0 . However @entity4 , @entity3 , @entity5 and insulin were thought to act together to establish body homeostasis in @entity0 with @entity1 and @entity2 .

title: The Effect of @entity6 /exon-3 Polymorphism and Serum XXXX , @entity3 and @entity5 Levels in @entity2 .

answer: @entity4


abstract: AIM: The present study investigated the effects of @entity4 ( @entity4 ), @entity3 ( @entity3 ), @entity5 ( @entity5 ) and @entity6 ( @entity6 )/exon-3 polymorphism on @entity1 ( @entity1 ) and @entity2 ( @entity2 ) @entity0 . @entity0 AND METHODS: Ninety @entity0 with @entity2 , 90 @entity0 with @entity1 and 96 controls were included in this study. The @entity4 , @entity3 and @entity5 serum levels were measured with enzyme-linked immunosorbent assay. @entity6 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity6 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity4 , @entity3 and @entity5 were not distributed according to @entity6 /exon-3 variants. However, in the @entity1 group, higher levels of @entity3 and lower levels of @entity4 and @entity5 , and in @entity2 group lower levels of @entity3 , @entity4 and @entity5 were observed. The order of @entity4 levels were @entity1 < @entity2 < Controls; @entity3 levels were @entity2 <Controls< @entity1 and @entity5 levels were @entity2 < @entity1 <Controls. CONCLUSION: No direct effect of @entity6 /exon-3 polymorphism was observed in @entity1 or @entity2 @entity0 . However @entity4 , @entity3 , @entity5 and insulin were thought to act together to establish body homeostasis in @entity0 with @entity1 and @entity2 .

title: The Effect of @entity6 /exon-3 Polymorphism and Serum @entity4 , @entity3 and @entity5 Levels in XXXX .

answer: @entity2


abstract: AIM: The present study investigated the effects of @entity4 ( @entity4 ), @entity3 ( @entity3 ), @entity5 ( @entity5 ) and @entity6 ( @entity6 )/exon-3 polymorphism on @entity1 ( @entity1 ) and @entity2 ( @entity2 ) @entity0 . @entity0 AND METHODS: Ninety @entity0 with @entity2 , 90 @entity0 with @entity1 and 96 controls were included in this study. The @entity4 , @entity3 and @entity5 serum levels were measured with enzyme-linked immunosorbent assay. @entity6 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity6 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity4 , @entity3 and @entity5 were not distributed according to @entity6 /exon-3 variants. However, in the @entity1 group, higher levels of @entity3 and lower levels of @entity4 and @entity5 , and in @entity2 group lower levels of @entity3 , @entity4 and @entity5 were observed. The order of @entity4 levels were @entity1 < @entity2 < Controls; @entity3 levels were @entity2 <Controls< @entity1 and @entity5 levels were @entity2 < @entity1 <Controls. CONCLUSION: No direct effect of @entity6 /exon-3 polymorphism was observed in @entity1 or @entity2 @entity0 . However @entity4 , @entity3 , @entity5 and insulin were thought to act together to establish body homeostasis in @entity0 with @entity1 and @entity2 .

title: The Effect of @entity6 /exon-3 Polymorphism and Serum @entity4 , XXXX and @entity5 Levels in @entity2 .

answer: @entity3


abstract: AIM: The present study investigated the effects of @entity4 ( @entity4 ), @entity3 ( @entity3 ), @entity5 ( @entity5 ) and @entity6 ( @entity6 )/exon-3 polymorphism on @entity1 ( @entity1 ) and @entity2 ( @entity2 ) @entity0 . @entity0 AND METHODS: Ninety @entity0 with @entity2 , 90 @entity0 with @entity1 and 96 controls were included in this study. The @entity4 , @entity3 and @entity5 serum levels were measured with enzyme-linked immunosorbent assay. @entity6 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity6 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity4 , @entity3 and @entity5 were not distributed according to @entity6 /exon-3 variants. However, in the @entity1 group, higher levels of @entity3 and lower levels of @entity4 and @entity5 , and in @entity2 group lower levels of @entity3 , @entity4 and @entity5 were observed. The order of @entity4 levels were @entity1 < @entity2 < Controls; @entity3 levels were @entity2 <Controls< @entity1 and @entity5 levels were @entity2 < @entity1 <Controls. CONCLUSION: No direct effect of @entity6 /exon-3 polymorphism was observed in @entity1 or @entity2 @entity0 . However @entity4 , @entity3 , @entity5 and insulin were thought to act together to establish body homeostasis in @entity0 with @entity1 and @entity2 .

title: The Effect of XXXX /exon-3 Polymorphism and Serum @entity4 , @entity3 and @entity5 Levels in @entity2 .

answer: @entity6


abstract: BACKGROUND: @entity3 accounts for 85%-90% of all @entity1 and currently has very limited therapeutic options. Recent studies of b-adrenergic antagonists suggest they may have neuroprotective effects that lead to improved functional outcomes in rodent models of @entity3 ; however, there are limited data in @entity0 . We aimed to determine whether there was an improvement in mortality rates among @entity0 who were taking b-blockers during the acute phase of their @entity3 . METHODS: A retrospective analysis of a prospectively collected database of @entity3 @entity0 was performed. @entity0 who were on b-adrenergic antagonists both at home and during the first 3 days of hospitalization were compared with @entity0 who were not on b-adrenergic antagonists to determine the association with @entity0 mortality rates. RESULTS: The study included a @entity0 population of 2804 @entity0 . In univariate analysis, use of b-adrenergic antagonists was associated with older age, @entity4 , @entity2 , and more-severe @entity1 . Despite this, multivariable analysis revealed a reduction in in-hospital mortality among @entity0 who were treated with b-adrenergic antagonists (odds ratio, .657; 95% confidence interval, .655-.658). CONCLUSIONS: The continuation of home b-adrenergic antagonist medication during the first 3 days of hospitalization after an @entity3 is associated with a decrease in @entity0 mortality. This supports the work done in rodent models suggesting neuroprotective effects of b-blockers after @entity3 .

title: Effect of b-Adrenergic Antagonists on In-Hospital Mortality after XXXX .

answer: @entity3


abstract: BACKGROUND: The @entity3 is the prime medial stabiliser of the knee and is a commonly injured structure which leads to valgus instability of the knee. OBJECTIVES: We aim to analyse differences in recovery of knee motion and muscle function over one year follow up in the @entity3 and combined ACL- @entity3 injured knee. We hypothesized that combined ACL- @entity1 lead to greater knee motion and muscle function deficits at 1 year. METHODS: @entity3 (Group I) or combined ACL- @entity1 (Group II) from 2006-2010 were included. Those with a previous @entity1 , @entity1 or presenting 2 weeks post-injury were excluded. At certain outpatient follow up intervals, we recorded pre-determined parameters of knee function. Follow-up was at weeks 2, 6, 12, 26, 52. RESULTS: The cohort included 82 @entity0 (54 males:28 females) with a mean age of 32 (range 16-56). Group II showed a deficit in Total Range of Movement (TROM) and flexion at 6 month follow up (p  <  0.05). Group II showed an extension deficit at week 2 (p  <  0.05). The Peak Torque Deficit (PTD) and Average Power Deficit (APD) improved for quadriceps and hamstrings across all follow up intervals (p  >  0.05). CONCLUSION: There is a @entity2 at 6 months in group II, resolving by 1 year. There was no difference in PTD or APD in either group.

title: Recovery of knee function in the XXXX and combined ACL- @entity3 deficient knee.

answer: @entity3


abstract: BACKGROUND: The @entity3 is the prime medial stabiliser of the knee and is a commonly injured structure which leads to valgus instability of the knee. OBJECTIVES: We aim to analyse differences in recovery of knee motion and muscle function over one year follow up in the @entity3 and combined ACL- @entity3 injured knee. We hypothesized that combined ACL- @entity1 lead to greater knee motion and muscle function deficits at 1 year. METHODS: @entity3 (Group I) or combined ACL- @entity1 (Group II) from 2006-2010 were included. Those with a previous @entity1 , @entity1 or presenting 2 weeks post-injury were excluded. At certain outpatient follow up intervals, we recorded pre-determined parameters of knee function. Follow-up was at weeks 2, 6, 12, 26, 52. RESULTS: The cohort included 82 @entity0 (54 males:28 females) with a mean age of 32 (range 16-56). Group II showed a deficit in Total Range of Movement (TROM) and flexion at 6 month follow up (p  <  0.05). Group II showed an extension deficit at week 2 (p  <  0.05). The Peak Torque Deficit (PTD) and Average Power Deficit (APD) improved for quadriceps and hamstrings across all follow up intervals (p  >  0.05). CONCLUSION: There is a @entity2 at 6 months in group II, resolving by 1 year. There was no difference in PTD or APD in either group.

title: Recovery of knee function in the @entity3 and combined ACL- XXXX deficient knee.

answer: @entity3


abstract: Lower body positive pressure (LBPP), or 'anti-gravity' treadmills   have become increasingly popular among elite distance runners. However, to date, few studies have assessed the effect of body weight support ( @entity2 ) on the metabolic cost of running among elite runners. This study evaluated how @entity2 influenced the relationship between velocity and metabolic cost among 6 elite male distance runners. @entity0 ran three- 16 minute tests consisting of 4 stages of 4 minutes at 8, 7, 6 and 5 min  mile(-1) pace (3.35, 3.84, 4.47 and 5.36 m  s(-1)), while maintaining an aerobic effort (Respiratory Exchange Ratio  <=1.00). One test was run on a regular treadmill, one on an anti-gravity treadmill with 40% @entity2 and one with 20% @entity2 being provided. Expired gas data were collected and regression equations used to determine and compare slopes. Significant decreases in @entity1 uptake ( @entity3 ) were found with each increase in @entity2 (p < 0.001). At 20% @entity2 , the average decrease in net VO2 was greater than proportional (34%), while at 40% @entity2 , the average net reduction in VO2 was close to proportional (38%). Across velocities, the slope of the relationship between VO2 and velocity (  @entity3 /  v) was steeper with less support. The slopes at both the 20% and 40% @entity2 conditions were similar, especially when compared to the regular treadmill. Variability in VO2 between athletes was much greater on the LBPP treadmill and was greater with increased levels of @entity2 . In this study we evaluated the effect of body weight support on @entity3 among elite distance runners. We have shown that @entity1 uptake decreased with support, but not in direct proportion to that support. Further, because of the high variability in @entity1 uptake between athletes on the LBPP treadmill, prediction equations may not be reliable and other indicators (heart rate, perceived exertion or directly measured @entity1 uptake) should be used to guide training intensity when training on the LBPP treadmill. Key pointsWith increasing amounts of @entity2 ( @entity2 ), the slope of the relationship between velocity and @entity1 consumption (  @entity3 /  v) decreases significantly. This means the change in @entity1 consumption (VO2) is significantly smaller over a given change in velocity at higher amounts of @entity2 .There is a non-linear decrease in VO2 with increasing @entity2 . As such, with each increment in the amount of @entity2 provided, the reduction in VO2 becomes increasingly smaller.This paper provides first of its kind data on the effects of @entity2 on the cost of running among highly trained, elite runners. The outcomes of this study are in line with previous findings among non-elite runners.

title: XXXX consumption of elite distance runners on an anti-gravity treadmill  .

answer: @entity1


abstract: The skeletal muscle in aged @entity0 adapts rapidly following a period of exercise. This adaptation includes structural remodeling and biochemical changes such as an up-regulation of antioxidant enzymes, content of stress and @entity3 proteins (HSPs). However, the associated molecular mechanisms mediating different types of exercise training-induced adaptations are not yet completely understood. Therefore, the purpose of this study was to investigate the effects of duration and frequency exercise on the expression of HSPs, antioxidant enzymes, and mitogen-activated protein kinase (MAPKs) in the skeletal muscles of aged @entity0 . Young (3-month-old) and aged (20-month-old) male @entity0 were randomly assigned to 6 groups and extensor digitorum longus (EDL; fast twitch muscle fiber) and soleus (SOL; slow twitch muscle fiber) skeletal muscles were collected immediately. The expression pattern of HSPs in skeletal muscles was decreased in old groups compared with young groups. Especially, HSPs showed lower expression in SOL than EDL muscle. Interestingly, HSPs in aged @entity0 was increased significantly after S1 (single long-duration; 1*30 min, 5 days/week for 6 weeks) and M1 types (multiple short-duration; 3*10 min  day(-1), 5 days  week(-1) for 6 weeks) than S2 (single long-duration; 1*30 min, 3 days/week for 6 weeks) and M2 (multiple short-duration; 3*10 min  day(-1), 3 days  week(-1) for 6 weeks) types of exercise training. Also, @entity1 dismutase (SODs) showed similar expression as HSP did. On the contrary, the p-ERK and p-JNK were down regulated. In addition, p-p38 level in the SOL muscle was activated markedly in all exercise groups. These results demonstrate that increasing of HSP expression through duration and frequency exercise can lead to protection and training-induced adaptation against aging-induced @entity2 . Key pointsThe expression of @entity3 proteins (HSPs) in aged @entity0 was increased significantly after single long-duration (S1) and multiple short-duration (M1) types than S2 and M2 types of exercise training in soleus (SOL) skeletal muscles.Superoxide dismutase (SODs) showed similar expression as HSPs did. On the contrary, the p-ERK and p-JNK were down regulated. In addition, p-p38 level in the SOL muscle was activated markedly in all exercise groups.Induction of HSPs and SODs by high duration and frequency of exercise training such as S1 and M1 types with concomitant MAPKs pathway depending on the type of muscles.The frequency and duration of exercise training could affect the functional adaptation and protection against aging-induced @entity2 through changing expression of related molecules.

title: Expression of XXXX Proteins (HSPs) in Aged Skeletal Muscles Depends on the Frequency and Duration of Exercise Training.

answer: @entity3


abstract: UNASSIGNED: Knowing the subcellular compartments of @entity0 proteins is essential to shed light on the mechanisms of a broad range of @entity0 diseases. In computational methods for protein subcellular localization, knowledge-based methods (especially @entity1 ( @entity1 ) based methods) are known to perform better than sequence-based methods. However, existing @entity1 -based predictors often lack interpretability and suffer from overfitting due to the high dimensionality of feature vectors. To address these problems, this paper proposes an interpretable multi-label predictor, namely mLASSO-Hum, which can yield sparse and interpretable solutions for large-scale prediction of @entity0 protein subcellular localization. By using the one-vs-rest @entity2 -based classifiers, 87 out of more than 8000 @entity1 terms are found to play more significant roles in determining the subcellular localization. Based on these 87 essential @entity1 terms, we can decide not only where a protein resides within a cell, but also why it is located there. To further exploit information from the remaining @entity1 terms, a method based on the @entity1 hierarchical information derived from the depth distance of @entity1 terms is proposed. Experimental results show that mLASSO-Hum performs significantly better than state-of-the-art predictors. We also found that in addition to the @entity1 terms from the cellular component category, @entity1 terms from the other two categories also play important roles in the final classification decisions. For readers*  convenience, the mLASSO-Hum server is available online at http://bioinfo.eie.polyu.edu.hk/mLASSOHumServer/.

title: mLASSO-Hum: A LASSO-based interpretable XXXX -protein subcellular localization predictor.

answer: @entity0


abstract: UNASSIGNED: This retrospective medical chart review aimed to provide a current, real-world overview of biologic usage in @entity0 with @entity1 ( @entity1 ) in Germany, Spain, and the UK, and estimate clinical and healthcare utilization outcomes associated with early versus late treatment. Adults (>= 18  years) with a confirmed @entity1 diagnosis between January 2008 and December 2010, who received biologic treatment for >= 3  months and had >= 12  months of follow-up were included. Early treatment was receipt of biologic agent  <=1  year after @entity1 diagnosis. Outcomes included 28-joint disease activity score (DAS28) reduction of >= 1.2 from biologic start and remission (DAS28  <  2.6). Time to outcome was evaluated using Kaplan-Meier curves and log-rank tests. Of 328 @entity0 enrolled (Germany [n  =  111], Spain [n  =  106], UK [n  =  111]), 58.2  % received early biologic (Germany: 55.0  %, UK: 55.9  %, Spain: 64.2  %; p  =  0.321). First-line biologics were more frequent in Spain (26.4  %) and Germany (19.8  %) versus the UK (7.2  %; p  <  0.001). Late-treated @entity0 were hospitalized more often than early-treated @entity0 (10.5 vs 2.9  % [p  =  0.006] for 9.0 vs 5.4 mean inpatient days [p  =  0.408]). DAS28 was 5.1 at biologic initiation (n  =  310); 73.5  % of @entity0 had a DAS28 decrease of >= 1.2 and 44.5  % achieved remission. More @entity0 had DAS28 decrease of >= 1.2 (79.2 vs 65.9  %; p  =  0.009) and remission (51.1 vs 35.6  %; p  =  0.007) with early versus late treatment, with a significant difference in Kaplan-Meier curves when indexing on time since diagnosis (p  <  0.001) and biologic start (p  =  0.024). In @entity1 @entity0 receiving biologic therapy, over half received biologic therapy early. Early initiation was associated with improved clinical outcomes and reduced hospitalization rates versus late treatment.

title: A European chart review study on early XXXX treatment patterns, clinical outcomes, and healthcare utilization.

answer: @entity1


abstract: INTRODUCTION: @entity0 with invasive @entity2 are commonly referred for @entity3 ( @entity3 ) detection. A recently proposed 3D tomographic imaging modality is freehand SPECT (declipseSPECT). This "bedside system" was originally developed to enable minimal-invasive image-guided surgery. The aim of this retrospective analysis was to assess the clinical use of this freehand detector device for image-guided lymphatic mapping in @entity2 @entity0 . MATERIALS AND METHODS: Thirty-nine @entity0 (12 female and 27 male subjects) were included (age, 30-79 years). All of them had at least one location of @entity2 with @entity1 stage pT1b or greater in 37 and pTx in 2 @entity0 in different sites of the body (abdomen in 4, back in 14, head and neck in 5, lower extremity in 6, and @entity4 in 10 @entity0 ). Lymphoscintigraphy was performed with 65 to 127 MBq Tc-nanocolloid. A 2-day protocol was applied with SPECT-CT acquisition (Brightview XCT, Philips) at day 1 and surgery using radio-guided freehand SPECT at day 2. SPECT-CT data were integrated into the 3D navigation system to enable fast and direct localization of the @entity3 by displaying the depth of the node from the skin surface and lateral margins in relation to the gamma probe. RESULTS: Comparable preoperative imaging and intraoperative localization was observed in 18 @entity0 . In 14 cases, more lymph nodes were resected than detected by SPECT-CT including 1 @entity0 without evidence of an @entity3 because this node was located close to the primary @entity1 . In 10 of these @entity0 , intraoperative freehand SPECT revealed additional sites of lymph nodes. In 7 cases, more findings were detected by SPECT-CT than surgically removed. The procedure was safe and easy to perform, and the time of surgical intervention using freehand SPECT was in the range of 36 to 133 minutes (mean time, 66.56 minutes). CONCLUSIONS: Freehand SPECT detected more @entity3 compared with SPECT-CT, and the tracking system provided precise anatomical localization of the radioactive-labeled SLNs.

title: Clinical Usefulness of a Novel Freehand 3D Imaging Device for Radio-Guided Intraoperative Sentinel Lymph Node Detection in XXXX .

answer: @entity2


abstract: OBJECTIVE: Transpedicular instrumentation of the @entity6 spine is a challenge for the spine surgeon due to the probability of screw loosening and the potential possibility of nonunion. The purpose of this study was to evaluate the clinical efficacy of bone cement augmented screw fixation in @entity0 with severe @entity3 . METHODS: Between February 2004 and August 2007, 250 @entity0 with severe @entity3 (T-score on BMD < -3.0) that had screw fixation were included in this study. The @entity0 were divided into two groups (Group I: 157 @entity0 that underwent bone cement augmented screw fixation that had a variety of spine spinal diseases including @entity4 , and Group II: 93 @entity0 with severe @entity3 that had screw fixation without bone cement augmentation). The imaging and clinical features were analyzed, including bone cement augmented levels, fusion rate and related complications. The visual analog scale (VAS), @entity5 questionnaire (ODI) and modified MacNab's criteria were used for the assessment of @entity2 and functional capacity. RESULTS: In both groups, a significant improvement in the VAS and ODI was achieved. 146 out of 157 @entity0 (93%) in Group I and 83 out of 93 @entity0 (90%) in Group II were graded as an excellent or good result according to the modified MacNab's criteria. None of the @entity0 experienced serious complications. However, there were two cases with @entity1 as a result of bone cement extravasation in Group I. For Group II, there were five cases of screw loosening that required re-operation for bone cement augmentation. CONCLUSION: Whether bone cement augmentation was performed or not, it was possible to achieve satisfactory results in @entity0 with severe @entity3 . However, if used carefully, bone cement augmented transpedicular screwing can reduce screw loosening and pullout in @entity0 with severe @entity3 .

title: Clinical efficacy of bone cement augmented screw fixation for the severe XXXX spine.

answer: @entity6


abstract: OBJECTIVE: This study was performed to describe the clinical presentation, surgical outcome in @entity0 with symptomatic @entity4 caused by ossification of the yellow ligament (OYL). METHODS: The authors reviewed consequent 12 @entity0 in whom posterior decompressive laminectomies were performed for OYL from 1999 to 2005. Diagnostic imagings including simple radiographs, computed tomography and magnetic resonance images were performed in each case. The @entity0 were reviewed to evaluate the clinical presentation, surgical outcome and complications of the operation. RESULTS: In all @entity0 , OYL was located in the lower thoracic region and all @entity0 presented with @entity5 on both limbs and @entity3 . Among them, 5 @entity0 presented with gait disturbance due to paraparesis and two @entity0 had @entity6 . Decompressive laminectomy through a posterior approach using microscope resulted in improvement of symptoms in all @entity0 , but, recovery was incomplete in a half of the @entity0 . The mean postoperative Japanese orthopaedics association (JOA) score was 7.9 when compared with 4.9 in preoperative assessment and the mean recovery rate was 65%. Dural tear was noticed in four @entity0 , so dural repair was performed, but there were no @entity1 related to @entity2 . CONCLUSION: OYL is an uncommon cause of @entity4 but it can lead to debilitating thoracic @entity4 . Careful decompressive laminectomy can achieve favorable results.

title: Symptomatic XXXX caused by ossification of the yellow ligament.

answer: @entity4


abstract: The conventional wheelchair sling seat provides little or no support to the spine of a @entity0 with @entity2 or @entity4 . As the spinal muscles become @entity5 may develop with @entity1 , @entity3 and restriction of cardio-respiratory function. If @entity4 is severe, the resultant fully developed @entity1 is virtually impossible to treat. Slowing the rate of @entity1 is, therefore, the most hopeful avenue of attack. This work addresses the hypothesis that custom moulded seating can increase sitting comfort and slow the rate of progression of spinal curvature in @entity0 with @entity5 , and further, that a range of standard or modular seats can achieve these goals at less cost. Previous work on this problem has ranged from simply padding the armrest, in order to distribute force over the rib cage, through to custom moulded seating. Our initial experience with custom moulding, using the bean bag evacuation and consolidation technique, produced several comfortable seats although the technique was labour intensive and therefore costly. This led us to attempt to develop a method of providing comfortable seating that would help control @entity1 at reasonable cost. This paper describes the design of a standardized seating system for school age @entity0 with @entity2 or @entity4 . Preliminary results indicate that this technique may have advantages over alternative methods of treatment. The radiological study is continuing.

title: Modular seating for XXXX : design and initial experience.

answer: @entity5


abstract: Background Context. Cement leakage is not a rare complication of vertebroplasty, but ascending @entity6 is exceptionally rare. We herein report the first case to our knowledge of this complication related to vertebroplasty. Purpose. We herein report the first case of ascending @entity6 following epidural cement leakage after percutaneous vertebroplasty in a @entity0 with multiple @entity7 . Study Design. CASE REPORT: Methods. A 64-year-old @entity0 with T8, T10, L2, and L4 @entity7 underwent percutaneous vertebroplasty using polymethylmethacrylate. 40 minutes after the procedure the @entity0 started suffering back and leg @entity1 , having repetitive @entity4 lasting 15 seconds of the lower extremities, @entity5 , @entity9 , @entity2 , and @entity3 . Results. The @entity0 recovered completely due to a combination of early effective resuscitation and considered definitive management. Conclusions. Percutaneous vertebroplasty with @entity8 is relatively safe but has few dangerous complications, which should be prevented by a meticulous technique and excellent image quality.

title: Ascending XXXX after percutaneous vertebroplasty.

answer: @entity6


abstract: We describe a 16-year-old Caucasian @entity0 who presented with @entity3 -sensitive @entity5 aged 2 years. His clinical course was one of frequent relapses and severe @entity3 dependence. To manage this, he was sequentially treated with @entity7 , then oral @entity4 before being started on @entity2 . A renal biopsy performed prior to commencement of @entity2 confirmed minimal change disease on light microscopy. The immunohistochemistry and electron microscopy findings were in keeping with this. His complement levels were normal and his lupus serology negative. He remained on @entity2 therapy for 8 years and had two further renal biopsies to detect @entity2 -induced @entity1 . Both biopsies showed evidence of increasing amounts of @entity6 deposition on immunohistochemistry and the presence of immune deposits on electron microscopy. As he had continued negative lupus serology, this was compatible with a diagnosis of @entity6 @entity1 . In addition both biopsies had changes compatible with chronic mild @entity2 nephrotoxicity. This case is the first report describing in detail a paediatric @entity0 with evolving @entity6 @entity1 who was treated successfully with rituximab. We discuss the role of @entity6 in this clinicopathological entity and question its significance.

title: @entity6 XXXX : a true immune complex disease or an immunologic epiphenomenon?

answer: @entity1


abstract: We describe a 16-year-old Caucasian @entity0 who presented with @entity3 -sensitive @entity5 aged 2 years. His clinical course was one of frequent relapses and severe @entity3 dependence. To manage this, he was sequentially treated with @entity7 , then oral @entity4 before being started on @entity2 . A renal biopsy performed prior to commencement of @entity2 confirmed minimal change disease on light microscopy. The immunohistochemistry and electron microscopy findings were in keeping with this. His complement levels were normal and his lupus serology negative. He remained on @entity2 therapy for 8 years and had two further renal biopsies to detect @entity2 -induced @entity1 . Both biopsies showed evidence of increasing amounts of @entity6 deposition on immunohistochemistry and the presence of immune deposits on electron microscopy. As he had continued negative lupus serology, this was compatible with a diagnosis of @entity6 @entity1 . In addition both biopsies had changes compatible with chronic mild @entity2 nephrotoxicity. This case is the first report describing in detail a paediatric @entity0 with evolving @entity6 @entity1 who was treated successfully with rituximab. We discuss the role of @entity6 in this clinicopathological entity and question its significance.

title: XXXX @entity1 : a true immune complex disease or an immunologic epiphenomenon?

answer: @entity6


abstract: @entity12 has been documented in only a handful of @entity0 under the age of four. We describe a 3-year-old @entity0 presenting with @entity4 and @entity2 whose kidney biopsy showed @entity6 ( @entity6 ) disease. She was treated aggressively with pulse @entity3 , plasmapheresis and monthly infusions of @entity8 . After months of aggressive immunosuppression, her renal function normalized, and her anti- @entity6 antibody disappeared. A year after the onset, she underwent a second kidney biopsy for persistent @entity7 and @entity1 that surprisingly showed focal sclerosing @entity6 , an unreported finding at this age. The biopsy showed deposition of antibody on the @entity6 despite the fact that anti- @entity6 antibody had normalized in the serum 5 months earlier. @entity5 was added to the immunosuppression at that point. At her 3-year follow-up, @entity10 clearance was 88.4 mL/ @entity9 .73 m(2), @entity7 was 408 mg/day and blood pressure was controlled with @entity11 0.2 mg/kg/day. She has not had a relapse or abnormal anti- @entity6 antibody for 30 months, but her renal prognosis remains guarded. To our knowledge, this is the youngest @entity0 to have a successful rescue of renal function after isolated @entity12 .

title: Rescue of renal function in a 3-year-old @entity0 with XXXX with a brief review of literature.

answer: @entity12


abstract: @entity12 has been documented in only a handful of @entity0 under the age of four. We describe a 3-year-old @entity0 presenting with @entity4 and @entity2 whose kidney biopsy showed @entity6 ( @entity6 ) disease. She was treated aggressively with pulse @entity3 , plasmapheresis and monthly infusions of @entity8 . After months of aggressive immunosuppression, her renal function normalized, and her anti- @entity6 antibody disappeared. A year after the onset, she underwent a second kidney biopsy for persistent @entity7 and @entity1 that surprisingly showed focal sclerosing @entity6 , an unreported finding at this age. The biopsy showed deposition of antibody on the @entity6 despite the fact that anti- @entity6 antibody had normalized in the serum 5 months earlier. @entity5 was added to the immunosuppression at that point. At her 3-year follow-up, @entity10 clearance was 88.4 mL/ @entity9 .73 m(2), @entity7 was 408 mg/day and blood pressure was controlled with @entity11 0.2 mg/kg/day. She has not had a relapse or abnormal anti- @entity6 antibody for 30 months, but her renal prognosis remains guarded. To our knowledge, this is the youngest @entity0 to have a successful rescue of renal function after isolated @entity12 .

title: Rescue of renal function in a 3-year-old XXXX with @entity12 with a brief review of literature.

answer: @entity0


abstract: BACKGROUND: Limited data exist regarding the effect of the growth process on anterior cruciate ligament (ACL) injury risk in male versus female @entity0 . HYPOTHESIS: The proportion of @entity1 /sports injuries presenting to clinic will vary by age, sex, and body mass index (BMI). STUDY DESIGN: Cross-sectional epidemiologic study. LEVEL OF EVIDENCE: Level 3. METHODS: The study group consisted of a randomly selected 5% probability sample of all @entity0 5 to 17 years of age presenting to a sports medicine clinic from January 1, 2000 to December 31, 2009; 2133 charts were reviewed. Data collected included demographics, height and weight, injury mechanism, diagnosis, treatment, @entity1 , and organized sports. RESULTS: A total of 206 ACL tears were analyzed (104 @entity0 , 102 @entity0 ). @entity0 were slightly older than @entity0 (15.1    1.7 vs 14.3    2.1 years; P < 0.01). Male-female comparison of @entity1 /total injury by age revealed that @entity0 had a steeper increase by age than @entity0 . Among 5- to 12-year-olds, @entity0 had a higher @entity1 /total injury ratio than @entity0 (all P < 0.01). @entity0 13 to 17 years of age showed no significant difference for sex in @entity1 /total injury ratio. As age advanced, the proportion of @entity1 /total injuries increased for both @entity0 (P < 0.01) and @entity0 (P = 0.04). BMI was independently associated with an @entity1 (P < 0.01). CONCLUSION: The proportion of @entity1 /total injuries was similar for @entity0 and @entity0 aged 13 to 17 years. @entity0 showed a significantly steeper increase in @entity1 proportion versus @entity0 through puberty. CLINICAL RELEVANCE: This study will increase clinician awareness of @entity1 occurrence in young male and female athletes 5 to 12 years of age. Injury prevention efforts should target young @entity0 before the onset of puberty and before injury occurs.

title: Anterior cruciate XXXX in pediatric athletes presenting to sports medicine clinic: a comparison of males and females through growth and development.

answer: @entity1


abstract: BACKGROUND: This multicenter international cross-sectional observational study characterized vascular and @entity4 burden and correlations with pulse pressure, @entity1 , @entity3 , and @entity2 in prevalent hemodialysis @entity0 . METHODS: We enrolled 275 consecutive adults with @entity5 on maintenance hemodialysis for    3 months. Coprimary endpoints were prevalences of: (1) echocardiographic @entity7 in mitral valve, aortic valve or mitral annulus; (2) @entity6 by plain lateral lumbar X-ray. Correlations among @entity7 sites and with demographics and comorbidities were determined. Pulse pressures were determined. RESULTS: Subjects' mean        standard deviation (SD) age was 56        15.9 years; mean (SD) dialysis duration was 4.5        4.3 years. Overall, 100% of echocardiographically imaged @entity0 (n   =   243) had @entity7 in aortic valve, mitral valve, or mitral annulus; 77.8% of X-rayed @entity0 (n   =   248) had @entity7 . Radiographic @entity7 score correlated significantly with @entity7 of aortic valve (p   <   0.0001) and mitral annulus (p   =   0.0001) but not mitral valve. Aortic valve, mitral valve, and @entity7 correlated significantly among themselves (p   <   0.0001). Moderate/severe @entity9 was significantly more prevalent in @entity0 aged    65 years than <65 years, @entity0 than @entity0 , and Whites than African Americans. Pulse pressure correlated significantly with @entity6 score (p   =   0.0049) but not with @entity4 at any site. CONCLUSIONS: Vascular and @entity4 are highly prevalent in the hemodialysis population. @entity8 correlates significantly with elevated pulse pressure and can be assessed easily using lateral lumbar X-ray. Further studies investigating the interaction between pulse pressure and development or progression of @entity6 are of interest.

title: The prevalence of @entity6 in @entity0 with XXXX on hemodialysis: a cross-sectional observational study.

answer: @entity5


abstract: BACKGROUND: This multicenter international cross-sectional observational study characterized vascular and @entity4 burden and correlations with pulse pressure, @entity1 , @entity3 , and @entity2 in prevalent hemodialysis @entity0 . METHODS: We enrolled 275 consecutive adults with @entity5 on maintenance hemodialysis for    3 months. Coprimary endpoints were prevalences of: (1) echocardiographic @entity7 in mitral valve, aortic valve or mitral annulus; (2) @entity6 by plain lateral lumbar X-ray. Correlations among @entity7 sites and with demographics and comorbidities were determined. Pulse pressures were determined. RESULTS: Subjects' mean        standard deviation (SD) age was 56        15.9 years; mean (SD) dialysis duration was 4.5        4.3 years. Overall, 100% of echocardiographically imaged @entity0 (n   =   243) had @entity7 in aortic valve, mitral valve, or mitral annulus; 77.8% of X-rayed @entity0 (n   =   248) had @entity7 . Radiographic @entity7 score correlated significantly with @entity7 of aortic valve (p   <   0.0001) and mitral annulus (p   =   0.0001) but not mitral valve. Aortic valve, mitral valve, and @entity7 correlated significantly among themselves (p   <   0.0001). Moderate/severe @entity9 was significantly more prevalent in @entity0 aged    65 years than <65 years, @entity0 than @entity0 , and Whites than African Americans. Pulse pressure correlated significantly with @entity6 score (p   =   0.0049) but not with @entity4 at any site. CONCLUSIONS: Vascular and @entity4 are highly prevalent in the hemodialysis population. @entity8 correlates significantly with elevated pulse pressure and can be assessed easily using lateral lumbar X-ray. Further studies investigating the interaction between pulse pressure and development or progression of @entity6 are of interest.

title: The prevalence of XXXX in @entity0 with @entity5 on hemodialysis: a cross-sectional observational study.

answer: @entity6


abstract: BACKGROUND: This multicenter international cross-sectional observational study characterized vascular and @entity4 burden and correlations with pulse pressure, @entity1 , @entity3 , and @entity2 in prevalent hemodialysis @entity0 . METHODS: We enrolled 275 consecutive adults with @entity5 on maintenance hemodialysis for    3 months. Coprimary endpoints were prevalences of: (1) echocardiographic @entity7 in mitral valve, aortic valve or mitral annulus; (2) @entity6 by plain lateral lumbar X-ray. Correlations among @entity7 sites and with demographics and comorbidities were determined. Pulse pressures were determined. RESULTS: Subjects' mean        standard deviation (SD) age was 56        15.9 years; mean (SD) dialysis duration was 4.5        4.3 years. Overall, 100% of echocardiographically imaged @entity0 (n   =   243) had @entity7 in aortic valve, mitral valve, or mitral annulus; 77.8% of X-rayed @entity0 (n   =   248) had @entity7 . Radiographic @entity7 score correlated significantly with @entity7 of aortic valve (p   <   0.0001) and mitral annulus (p   =   0.0001) but not mitral valve. Aortic valve, mitral valve, and @entity7 correlated significantly among themselves (p   <   0.0001). Moderate/severe @entity9 was significantly more prevalent in @entity0 aged    65 years than <65 years, @entity0 than @entity0 , and Whites than African Americans. Pulse pressure correlated significantly with @entity6 score (p   =   0.0049) but not with @entity4 at any site. CONCLUSIONS: Vascular and @entity4 are highly prevalent in the hemodialysis population. @entity8 correlates significantly with elevated pulse pressure and can be assessed easily using lateral lumbar X-ray. Further studies investigating the interaction between pulse pressure and development or progression of @entity6 are of interest.

title: The prevalence of @entity6 in XXXX with @entity5 on hemodialysis: a cross-sectional observational study.

answer: @entity0


abstract: BACKGROUND: Spatio-temporal patterns on benthic molluscan macrofauna structure and function (feeding guilds) were investigated in a commercial fishing ground in Thermaikos Gulf (N Aegean @entity3 ). Fishery management measures in this area include a trawling period of 8   months per year (October to May). Macrofauna samples were collected before and after 30 and 120   days of the commencement of the trawling period (temporal @entity1 ) along a southward transect ( @entity2 ) and down through the sediment profile (vertical @entity1 ). RESULTS: Main results revealed no recognizable changes in community diversity and structure at temporal scales. This finding can probably be attributed to the fact that the examined communities are subjected to continuous disturbances deriving from multiple natural and anthropogenic stressors acting simultaneously in Thermaikos Gulf. Molluscan assemblages were already stressed before the commencement of the trawling period, indicating that the time period in which bottom trawling is prohibited is not sufficient for the recovery of benthic communities. Significant shifts in the trophic structure of molluscan assemblages were also detected. The direct mortality of herbivorous species and the loss of filter feeding organisms may be attributed to the passage of the fishing gear and to sediment re-suspension, respectively. Trawling disturbance may have created the observed vertical patterns of the community structure since hauling induces profound changes in the geochemical profile of the sediment. CONCLUSIONS: Our findings sustained the notion that bottom trawling, alongside with other types of @entity0 induced stressors, can have considerable effects on the structure and function of the benthic domain. Therefore, our results highlighted the need of an Ecosystem Based Fishery Management (EBFM) perspective in Thermaikos Gulf to ensure both fisheries and ecosystem sustainability.

title: Benthic molluscan macrofauna structure in heavily trawled sediments (Thermaikos Gulf, North Aegean XXXX ): spatiotemporal patterns.

answer: @entity3


abstract: BACKGROUND: Bronchoscopy is frequently nondiagnostic in @entity0 with @entity3 suspected to be @entity1 . This often results in additional invasive testing, although many lesions are benign. We sought to validate a bronchial-airway gene-expression classifier that could improve the diagnostic performance of bronchoscopy. METHODS: Current or former smokers undergoing bronchoscopy for suspected @entity1 were enrolled at 28 centers in two multicenter prospective studies (AEGIS-1 and AEGIS-2). A gene-expression classifier was measured in epithelial cells collected from the normal-appearing mainstem bronchus to assess the probability of @entity1 . RESULTS: A total of 639 @entity0 in AEGIS-1 (298 @entity0 ) and AEGIS-2 (341 @entity0 ) met the criteria for inclusion. A total of 43% of bronchoscopic examinations were nondiagnostic for @entity1 , and invasive procedures were performed after bronchoscopy in 35% of @entity0 with benign lesions. In AEGIS-1, the classifier had an area under the receiver-operating-characteristic curve (AUC) of 0.78 (95% confidence interval [CI], 0.73 to 0.83), a sensitivity of 88% (95% CI, 83 to 92), and a specificity of 47% (95% CI, 37 to 58). In AEGIS-2, the classifier had an AUC of 0.74 (95% CI, 0.68 to 0.80), a sensitivity of 89% (95% CI, 84 to 92), and a specificity of 47% (95% CI, 36 to 59). The combination of the classifier plus bronchoscopy had a sensitivity of 96% (95% CI, 93 to 98) in AEGIS-1 and 98% (95% CI, 96 to 99) in AEGIS-2, independent of lesion size and location. In 101 @entity0 with an intermediate pretest probability of @entity2 , the negative predictive value of the classifier was 91% (95% CI, 75 to 98) among @entity0 with a nondiagnostic bronchoscopic examination. CONCLUSIONS: The gene-expression classifier improved the diagnostic performance of bronchoscopy for the detection of @entity1 . In intermediate-risk @entity0 with a nondiagnostic bronchoscopic examination, a negative classifier score provides support for a more conservative diagnostic approach. (Funded by Allegro Diagnostics and others; AEGIS-1 and AEGIS-2 ClinicalTrials.gov numbers, NCT01309087 and NCT00746759.).

title: A Bronchial Genomic Classifier for the Diagnostic Evaluation of XXXX .

answer: @entity1


abstract: OBJECTIVE: The prognosis of @entity0 -derived brain metastasis is poor, but new drugs and recent therapeutic strategies have helped extend survival in @entity1 . Prediction of therapeutic responses and outcomes is not yet possible, however. In a retrospective study, we examined prognostic factors in @entity1 with @entity0 -derived brain metastasis, and we tested the prognostic utility of a @entity0 -specific Graded Prognostic Assessment in these @entity1 . METHODS: Sixty-three @entity1 diagnosed with brain metastasis from @entity0 treated surgically and adjuvantly were included. We examined clinical variables per @entity2 subtype: ER+/ @entity3 - (luminal), @entity3 + ( @entity1 epidermal growth factor receptor type 2-enriched) or ER-/PR-/ @entity3 - (triple negative). We also categorized @entity1 ' @entity0 -specific Graded Prognostic Assessment scores and analyzed post-brain metastasis survival time in relation to these categories. RESULTS: The @entity0 comprised the following subtypes: luminal, n = 18; @entity1 epidermal growth factor receptor type 2-enriched, n = 27 and triple-negative, n = 18; median survival per subtype was 11, 37 and 3 months, respectively. Survival of @entity1 epidermal growth factor receptor type 2-enriched @entity1 was longer, though not significantly (P = 0.188), than that of luminal @entity1 . Survival of triple-negative @entity1 was significantly short (vs. @entity1 epidermal growth factor receptor type 2-enriched @entity1 , P < 0.001). Karnofsky performance status, @entity3 status and the disease-free interval (from initial treatment to first recurrence) were shown to be significant prognostic factors (Karnofsky performance status < 70: relative risk 2.08, P = 0.028; @entity3 +: relative risk 2.911, P = 0.004; disease-free interval < 24 months: relative risk 1.933, P = 0.011). @entity0 -specific Graded Prognostic Assessment scores reflected disease-free intervals and survival times. CONCLUSIONS: Our data indicate that @entity0 -specific Graded Prognostic Assessment-based prediction will be helpful in determining appropriate therapeutic strategies for @entity1 with brain metastasis from @entity0 .

title: Prolonged survival after diagnosis of brain metastasis from XXXX : contributing factors and treatment implications.

answer: @entity0


abstract: @entity4 ( @entity3 ) has been suggested to have neuroprotective effects against @entity1 ( @entity1 ); however, few studies have examined these effects and the corresponding mechanism. Therefore, the present study aimed to investigate the neuroprotective effect and underlying mechanism of @entity3 against contusive @entity1 . Adult male @entity0 were randomly divided into Sham, normal saline (NS) and @entity3 groups. Each group was divided into subgroups according to the time of sacrifice: 1, 3, 7, 14, 21 and 28  days post-injury. Laminectomy was performed in all groups, followed by contusive @entity1 establishment in the @entity3 and NS groups. @entity3 (80  mg/kg) was injected thereafter daily from 3 to 7  days post-injury in the @entity3 group, which was replaced by equal volume of normal saline in the NS group. The Basso-Beattie-Bresnahan (BBB) Locomotor Rating Scale was measured at different time points post-injury to appraise locomotor functional recovery. Quantitative real-time PCR and immunofluorescence were used to assess the spatio-temporal expression of peroxisome proliferator-activated receptor-y coactivator-1a ( @entity2 ), while western blot was adopted to detect the effect of @entity3 on @entity2 . Neural apoptotic changes and neuronal survival were evaluated using the TUNEL method and Nissl staining, respectively. @entity3 treatment markedly increased @entity2 expression, neuronal survival and BBB locomotor scores, while also reducing neural apoptosis. These results demonstrate that @entity3 is neuroprotective against contusive @entity1 , with the inhibition of neural apoptosis and increase of neuronal survival. The sustained expression of @entity2 may partially contribute to the @entity3 -mediated neuroprotective effect.

title: The Neuroprotective Effect of XXXX Against Contusive @entity1 by Activating @entity2 in @entity0 .

answer: @entity4


abstract: @entity4 ( @entity3 ) has been suggested to have neuroprotective effects against @entity1 ( @entity1 ); however, few studies have examined these effects and the corresponding mechanism. Therefore, the present study aimed to investigate the neuroprotective effect and underlying mechanism of @entity3 against contusive @entity1 . Adult male @entity0 were randomly divided into Sham, normal saline (NS) and @entity3 groups. Each group was divided into subgroups according to the time of sacrifice: 1, 3, 7, 14, 21 and 28  days post-injury. Laminectomy was performed in all groups, followed by contusive @entity1 establishment in the @entity3 and NS groups. @entity3 (80  mg/kg) was injected thereafter daily from 3 to 7  days post-injury in the @entity3 group, which was replaced by equal volume of normal saline in the NS group. The Basso-Beattie-Bresnahan (BBB) Locomotor Rating Scale was measured at different time points post-injury to appraise locomotor functional recovery. Quantitative real-time PCR and immunofluorescence were used to assess the spatio-temporal expression of peroxisome proliferator-activated receptor-y coactivator-1a ( @entity2 ), while western blot was adopted to detect the effect of @entity3 on @entity2 . Neural apoptotic changes and neuronal survival were evaluated using the TUNEL method and Nissl staining, respectively. @entity3 treatment markedly increased @entity2 expression, neuronal survival and BBB locomotor scores, while also reducing neural apoptosis. These results demonstrate that @entity3 is neuroprotective against contusive @entity1 , with the inhibition of neural apoptosis and increase of neuronal survival. The sustained expression of @entity2 may partially contribute to the @entity3 -mediated neuroprotective effect.

title: The Neuroprotective Effect of @entity4 Against Contusive @entity1 by Activating XXXX in @entity0 .

answer: @entity2


abstract: @entity4 ( @entity3 ) has been suggested to have neuroprotective effects against @entity1 ( @entity1 ); however, few studies have examined these effects and the corresponding mechanism. Therefore, the present study aimed to investigate the neuroprotective effect and underlying mechanism of @entity3 against contusive @entity1 . Adult male @entity0 were randomly divided into Sham, normal saline (NS) and @entity3 groups. Each group was divided into subgroups according to the time of sacrifice: 1, 3, 7, 14, 21 and 28  days post-injury. Laminectomy was performed in all groups, followed by contusive @entity1 establishment in the @entity3 and NS groups. @entity3 (80  mg/kg) was injected thereafter daily from 3 to 7  days post-injury in the @entity3 group, which was replaced by equal volume of normal saline in the NS group. The Basso-Beattie-Bresnahan (BBB) Locomotor Rating Scale was measured at different time points post-injury to appraise locomotor functional recovery. Quantitative real-time PCR and immunofluorescence were used to assess the spatio-temporal expression of peroxisome proliferator-activated receptor-y coactivator-1a ( @entity2 ), while western blot was adopted to detect the effect of @entity3 on @entity2 . Neural apoptotic changes and neuronal survival were evaluated using the TUNEL method and Nissl staining, respectively. @entity3 treatment markedly increased @entity2 expression, neuronal survival and BBB locomotor scores, while also reducing neural apoptosis. These results demonstrate that @entity3 is neuroprotective against contusive @entity1 , with the inhibition of neural apoptosis and increase of neuronal survival. The sustained expression of @entity2 may partially contribute to the @entity3 -mediated neuroprotective effect.

title: The Neuroprotective Effect of @entity4 Against Contusive XXXX by Activating @entity2 in @entity0 .

answer: @entity1


abstract: @entity4 ( @entity3 ) has been suggested to have neuroprotective effects against @entity1 ( @entity1 ); however, few studies have examined these effects and the corresponding mechanism. Therefore, the present study aimed to investigate the neuroprotective effect and underlying mechanism of @entity3 against contusive @entity1 . Adult male @entity0 were randomly divided into Sham, normal saline (NS) and @entity3 groups. Each group was divided into subgroups according to the time of sacrifice: 1, 3, 7, 14, 21 and 28  days post-injury. Laminectomy was performed in all groups, followed by contusive @entity1 establishment in the @entity3 and NS groups. @entity3 (80  mg/kg) was injected thereafter daily from 3 to 7  days post-injury in the @entity3 group, which was replaced by equal volume of normal saline in the NS group. The Basso-Beattie-Bresnahan (BBB) Locomotor Rating Scale was measured at different time points post-injury to appraise locomotor functional recovery. Quantitative real-time PCR and immunofluorescence were used to assess the spatio-temporal expression of peroxisome proliferator-activated receptor-y coactivator-1a ( @entity2 ), while western blot was adopted to detect the effect of @entity3 on @entity2 . Neural apoptotic changes and neuronal survival were evaluated using the TUNEL method and Nissl staining, respectively. @entity3 treatment markedly increased @entity2 expression, neuronal survival and BBB locomotor scores, while also reducing neural apoptosis. These results demonstrate that @entity3 is neuroprotective against contusive @entity1 , with the inhibition of neural apoptosis and increase of neuronal survival. The sustained expression of @entity2 may partially contribute to the @entity3 -mediated neuroprotective effect.

title: The Neuroprotective Effect of @entity4 Against Contusive @entity1 by Activating @entity2 in XXXX .

answer: @entity0


abstract: @entity9 is a sporadic alpha-synucleinopathy that typically affects @entity0 in their sixth decade of life and beyond. The defining clinical features of the disease include @entity10 , @entity4 , and @entity7 leading to significant disability. Pathologically, multiple system @entity3 is characterized by glial cytoplasmic inclusions containing filamentous @entity8 . @entity5 also have been reported but remain less well defined. This study aimed to further define the spectrum of neuronal pathology in 35 @entity0 with multiple system @entity3 (20 male, 15 female; mean age at death 64.7 years; median disease duration 6.5 years, range 2.2 to 15.6 years). The morphologic type, topography, and frequencies of neuronal inclusions, including globular cytoplasmic (Lewy body-like) neuronal inclusions, were determined across a wide spectrum of brain regions. A correlation matrix of pathologic severity also was calculated between distinct anatomic regions of involvement (striatum, substantia nigra, olivary and pontine nuclei, hippocampus, forebrain and thalamus, anterior cingulate and neocortex, and white matter of cerebrum, cerebellum, and corpus callosum). The major finding was the identification of widespread neuronal inclusions in the majority of @entity0 , not only in typical disease-associated regions (striatum, substantia nigra), but also within anterior cingulate cortex, amygdala, entorhinal cortex, basal forebrain and hypothalamus. Neuronal inclusion pathology appeared to follow a hierarchy of region-specific susceptibility, independent of the clinical phenotype, and the severity of pathology was duration-dependent. @entity5 also were identified in regions not previously implicated in the disease, such as within cerebellar roof nuclei. Lewy body-like inclusions in multiple system @entity3 followed the stepwise anatomic progression of Lewy body-spectrum disease inclusion pathology in 25.7% of @entity0 with multiple system @entity3 , including a @entity0 with @entity6 . Further, the presence of Lewy body-like inclusions in neocortex, but not hippocampal @entity8 pathology, was associated with @entity1 (P = 0.002). However, several cases had the presence of isolated Lewy body-like inclusions at atypical sites (e.g. thalamus, @entity2 ) that are not typical for Lewy body-spectrum disease. Finally, interregional correlations (rho >=  0.6) in pathologic glial and @entity5 burden suggest shared mechanisms of disease progression between both discrete anatomic regions (e.g. basal forebrain and hippocampus) and cell types (neuronal and glial inclusions in frontal cortex and white matter, respectively). These findings suggest that in addition to glial inclusions, neuronal pathology plays an important role in the developmental and progression of multiple system @entity3 .

title: Expanding the spectrum of neuronal pathology in multiple system XXXX .

answer: @entity3


abstract: BACKGROUND AND OBJECTIVES: Infra orbital nerve block is utilized for @entity3 control in @entity0 undergoing @entity12 repair. This study was conducted to compare the effectiveness, @entity11 and opioids for @entity3 relief following cheiloplasty. MATERIALS AND METHODS: Sixty paediatric @entity0 aged 3 months - 13 years undergoing cheiloplasty were selected by simple random sampling and were divided into two groups. All the @entity0 received standardized premedication with @entity9 , were operated upon under general anaesthesia and the block was performed at the end of surgery before reversal. Group B @entity0 were administered bilateral infra orbital nerve block with 0.25% @entity8 (upto 2 mg/kg). Group O @entity0 received @entity13 0.5 mg / kg IV. Postoperatively, the heart rate and respiratory rates were recorded every 15 minutes for the first 60 minutes, half hourly till 4 hours and then at 12 and 24 hours. Behavioural assessment for @entity2 / discomfort was done at intervals of   , 1, 2, 3, 4, 12 and 24 hours. Need for supplementary analgesics and duration between the administration of block/opioid and the first dose of supplementary analgesics were noted. Side effects such as @entity4 and @entity5 , @entity1 , @entity10 and @entity6 during each of these periods were noted. RESULTS: Both the groups were comparable for age, sex, weight and operative time with no statistical difference. The mean duration of @entity7 for infra orbital nerve block was 357.5 minutes i.e. 5 hours 58 minutes and that for opioid was 231 minutes i.e. 3 hours 51 minutes which was significantly lower than the hours of @entity7 provided by the block. Further, at the 4th hour, 76.6% of the @entity0 in Group O required supplementary analgesics, in contrast to only 16.6% in Group B. The incidence of @entity4 and @entity5 and @entity1 was also higher in Group O. CONCLUSION: The results indicate that bilateral infra orbital nerve block provides effective @entity7 in the postoperative period, lasting for 6 hours in comparison to 3   - 4 hours following the administration of intravenous @entity13 , with no major untoward effects.

title: Bilateral Infraorbital Nerve Block Versus Intravenous XXXX : A Comparative Study on Post-operative @entity2 Relief Following Cleft Lip Surgery.

answer: @entity13