abstract: The present study aimed to establish simple systems for measuring fecal @entity1 hormones in order to monitor the reproductive profiles of captive Hokkaido @entity7 . The efficiency of fecal sample processing at the steps of dehydration and extraction and the correlation between @entity1 concentrations in matched fecal and blood samples were studied. Then, monthly changes in fecal @entity0 -17 beta and @entity4 in female bears, and @entity2 in male bears were examined. The procedure was finalized as follows. Fecal samples were dried at 100 degrees C for 3 hr and extracted with @entity5 . The @entity5 in the extracts was evaporated and residues were reconstituted in @entity3 for the assays. @entity6 concentrations were quantified using enzyme immunoassays. Concentrations of @entity4 and @entity2 in fecal and plasma samples were correlated in the systems. The changes in fecal @entity4 and @entity2 concentrations were similar to those in serum concentrations of bears as reported previously. In contrast, fecal @entity0 concentrations did not correlate with plasma levels probably because of the time lag in excretion. However, the changes in @entity0 -17 beta concentrations in feces in the present study were similar to those reported in serum. In conclusion, fecal @entity4 and @entity2 assay systems appear practical for monitoring ovarian and testicular activities without immobilization, though methodological improvements and further validation may be required. For the fecal @entity0 -17 beta assay, there is a need to solve the problem of excretion time lag before the system can be used in the study of reproductive physiology.

title: Efficiency of fecal @entity1 hormone measurement for assessing reproductive function in the Hokkaido @entity7 ( XXXX yesoensis).

answer: @entity7


abstract: OBJECTIVE: To investigate superiorities of a special needle-over-cannula adopting different location methods for continuous femoral @entity4 (CFNB) for @entity6 . METHODS: 60 elderly @entity0 intending to receive scheduled knee or hip replacement surgery were recruited and divided into 3 groups randomly. Group 1 (n=20) adopted fascial pop for continuous femoral @entity4 and @entity1 with indwelling cannula. Group 2 (n=20) adopted location guided by B ultrasound, and Group 3 (n=20) adopted fascial pop combined with B ultrasound. RESULTS: There was significant difference in the performing time of cannula indwelling on average between each two groups (P<0.01). There was no significant difference among three groups about visual analogue scale (VAS) score, Ramsay sedation score (RSS), incidence of @entity3 and vomit, or @entity0 's satisfaction at 6, 12, 24 and 48 h. Infection at the puncture site, toxic reaction of local anesthetics and @entity5 were absent during the cannula indwelling. All the @entity0 did not receive any other analgesic, and the indwelling time of external cannula was 45.3 hours on average. There was only one @entity0 in group 2 who felt mild @entity2 in front of the thigh after removing the indwelling cannula. No stolidity or other abnormal symptom was found among the remaining @entity0 . CONCLUSIONS: Shorter indwelling cannula time and higher success rate of single attempt placement suggest that fascial pop combined ultrasound guidance is worth for clinical recommendation.

title: Special needle over cannula for XXXX in @entity6 .

answer: @entity1


abstract: OBJECTIVE: To investigate superiorities of a special needle-over-cannula adopting different location methods for continuous femoral @entity4 (CFNB) for @entity6 . METHODS: 60 elderly @entity0 intending to receive scheduled knee or hip replacement surgery were recruited and divided into 3 groups randomly. Group 1 (n=20) adopted fascial pop for continuous femoral @entity4 and @entity1 with indwelling cannula. Group 2 (n=20) adopted location guided by B ultrasound, and Group 3 (n=20) adopted fascial pop combined with B ultrasound. RESULTS: There was significant difference in the performing time of cannula indwelling on average between each two groups (P<0.01). There was no significant difference among three groups about visual analogue scale (VAS) score, Ramsay sedation score (RSS), incidence of @entity3 and vomit, or @entity0 's satisfaction at 6, 12, 24 and 48 h. Infection at the puncture site, toxic reaction of local anesthetics and @entity5 were absent during the cannula indwelling. All the @entity0 did not receive any other analgesic, and the indwelling time of external cannula was 45.3 hours on average. There was only one @entity0 in group 2 who felt mild @entity2 in front of the thigh after removing the indwelling cannula. No stolidity or other abnormal symptom was found among the remaining @entity0 . CONCLUSIONS: Shorter indwelling cannula time and higher success rate of single attempt placement suggest that fascial pop combined ultrasound guidance is worth for clinical recommendation.

title: Special needle over cannula for @entity1 in XXXX .

answer: @entity6


abstract: The cognitive (executive) ability of @entity0 with @entity3 ( @entity3 ) deteriorates gradually during the progression of the disease. Fluency of speech, word finding, working memory, ability to plan the future and flexibility decline. @entity2 was found to be proportional with the speech, posture, gait and balance problems and can not be influenced by L-dopa substitution. Apart the dorsal and ventral mesolimbic dopaminergic systems the coerulo-cortical noradrenergic, serotoninergic and cholinergic systems are also impaired in @entity3 . Subcortical @entity5 in @entity3 can also be explained by the functional disability of dorsolateral and anterior cingular circuits. @entity1 can be explained by the @entity9 depletion of cingular cortex. Cortical Lewy bodies, @entity12 , neurit plaques and additional vascular pathology should also play a role in @entity2 of @entity3 . In several @entity18 associating with @entity3 ( @entity3 ) i.e. @entity14 ( @entity14 ), @entity8 ( @entity8 ), @entity15 ( @entity15 ) @entity5 can be detected with various severity, therefore the question arises concerning the correlation between @entity2 and @entity3 . @entity6 can also develop in @entity13 ( @entity13 ), @entity4 and @entity10 ( @entity10 ) but no correlation exists between motor disability and severity of @entity5 . In @entity10 can be the initial symptom in 18% of cases but @entity3 can also preceeds the @entity5 . In @entity14 profound depletion of other monoaminergic neurotransmitter system was also reported. In @entity19 associated with @entity3 @entity8 , locus coeruleus and basal nucleus of Meynert has been reported with increased number of @entity12 . In @entity0 with vascular @entity3 (VP) there is generally no @entity7 and @entity11 , @entity17 , @entity5 , gate disturbance, incontinency appears; L-dopa treatment is generally ineffective. In VP no cellular loss can be found within the substantia nigra, but @entity16 , lacunae in the white matter and basal ganglia are commonly demonstrated.

title: [ XXXX and @entity2 ].

answer: @entity6


abstract: The cognitive (executive) ability of @entity0 with @entity3 ( @entity3 ) deteriorates gradually during the progression of the disease. Fluency of speech, word finding, working memory, ability to plan the future and flexibility decline. @entity2 was found to be proportional with the speech, posture, gait and balance problems and can not be influenced by L-dopa substitution. Apart the dorsal and ventral mesolimbic dopaminergic systems the coerulo-cortical noradrenergic, serotoninergic and cholinergic systems are also impaired in @entity3 . Subcortical @entity5 in @entity3 can also be explained by the functional disability of dorsolateral and anterior cingular circuits. @entity1 can be explained by the @entity9 depletion of cingular cortex. Cortical Lewy bodies, @entity12 , neurit plaques and additional vascular pathology should also play a role in @entity2 of @entity3 . In several @entity18 associating with @entity3 ( @entity3 ) i.e. @entity14 ( @entity14 ), @entity8 ( @entity8 ), @entity15 ( @entity15 ) @entity5 can be detected with various severity, therefore the question arises concerning the correlation between @entity2 and @entity3 . @entity6 can also develop in @entity13 ( @entity13 ), @entity4 and @entity10 ( @entity10 ) but no correlation exists between motor disability and severity of @entity5 . In @entity10 can be the initial symptom in 18% of cases but @entity3 can also preceeds the @entity5 . In @entity14 profound depletion of other monoaminergic neurotransmitter system was also reported. In @entity19 associated with @entity3 @entity8 , locus coeruleus and basal nucleus of Meynert has been reported with increased number of @entity12 . In @entity0 with vascular @entity3 (VP) there is generally no @entity7 and @entity11 , @entity17 , @entity5 , gate disturbance, incontinency appears; L-dopa treatment is generally ineffective. In VP no cellular loss can be found within the substantia nigra, but @entity16 , lacunae in the white matter and basal ganglia are commonly demonstrated.

title: [ @entity6 and XXXX ].

answer: @entity2


abstract: OBJECTIVE: To explore the correlation of miRNAs with clinical characteristics of ACS. METHODS: 50 ACS @entity0 and 50 healthy controls were randomly selected. On the basis of miRNA expression levels, ACS @entity0 were classified as low miRNA expression group (fold change: <3) and high miRNA expression group (>= 3). RESULTS: @entity1 expression increased markedly in the serum exosomes of ACS @entity0 , and @entity1 expression in the serum of ACS @entity0 was also significantly higher than that in healthy controls. However, the sensitivity of serum @entity1 was inferior to that of exosome @entity1 . Analysis of clinical characteristics showed the mean age of 500 ACS @entity0 was 62.35  9.70 years, and there were 300 @entity0 in low @entity1 expression group and 200 @entity0 in high @entity1 expression group. When compared with low @entity1 expression group, @entity0 with high @entity1 expression were older, and had higher Killip class, higher CK-MB peak, higher cTnT peak and elevated LDL (P<0.05). Within 1-year follow up, 32 @entity0 died including 10 in low @entity1 expression group with the mortality of 3.3% and 22 in high @entity1 expression group with the mortality of 11.0%. Kaplan-Meier survival analysis revealed that the 1-year survival rate reduced significantly in @entity0 with high @entity1 expression. CONCLUSION: miRNA-208a expression is significantly up-regulated in the serum exosomes of ACS @entity0 and is crucial for the diagnosis of ACS.

title: Correlation between serum exosome derived XXXX and acute coronary syndrome.

answer: @entity1


abstract: The appearance of viral strains that are resistant to protease inhibitors is one of the most serious problems in the chemotherapy of @entity4 / @entity3 . The most pervasive drug-resistant mutants are those that affect all inhibitors in clinical use. In this paper, we have characterized a multiple-drug-resistant mutant of the @entity4 protease that affects @entity5 , @entity6 , @entity0 , @entity1 , @entity7 , and @entity8 . This mutant (MDR-HM) contains six @entity2 mutations ( @entity12 / @entity14 / @entity13 / @entity10 / @entity9 / @entity11 ) located within and outside the active site of the enzyme. Microcalorimetric and enzyme kinetic measurements indicate that this mutant lowers the affinity of all inhibitors by 2-3 orders of magnitude. By comparison, the multiiple-drug-resistant mutant only increased the K(m) of the substrate by a factor of 2, indicating that the substrate is able to adapt to the changes caused by the mutations and maintain its binding affinity. To understand the origin of resistance, three submutants containing mutations in specific regions were also studied, i.e., the active site ( @entity10 / @entity9 ), flap region ( @entity14 / @entity13 ), and dimerization region ( @entity12 / @entity11 ). None of these sets of mutations by themselves lowered the affinity of inhibitors by more than 1 order of magnitude, and additionally, the sum of the effects of each set of mutations did not add up to the overall effect, indicating the presence of cooperative effects. A mutant containing only the four active site mutations ( @entity10 / @entity9 / @entity14 / @entity13 ) only showed a small cooperative effect, suggesting that the mutations at the dimer interface ( @entity12 / @entity11 ) play a major role in eliciting a cooperative response. These studies demonstrate that cooperative interactions contribute an average of 1.2 +/- 0.7 kcal/mol to the overall resistance, most of the cooperative effect (0.8 +/- 0.7 kcal/mol) being mediated by the mutations at the dimerization interface. Not all inhibitors in clinical use are affected the same by long-range cooperative interactions between mutations. These interactions can amplify the effects of individual mutations by factors ranging between 2 and 40 depending on the inhibitor. Dissection of the energetics of drug resistance into enthalpic and entropic components provides a quantitative account of the inhibitor response and a set of thermodynamic guidelines for the design of inhibitors with a lower susceptibility to this type of mutations.

title: Multidrug resistance to XXXX protease inhibition requires cooperative coupling between distal mutations.

answer: @entity4


abstract: BACKGROUND: We report results of @entity11 treated by a single group over 20 years. METHODS: Retrospective review. RESULTS: Seventeen @entity0 were treated, 10 with @entity4 . All had @entity7 , 88% were febrile, 71% had @entity6 , and 24% were hemodynamically unstable. The most common responsible organism was @entity8 (29%) followed by @entity10 organisms (24%). All suprarenal infections were gram-positive organisms. @entity4 were treated with preliminary axillofemoral bypass followed by aortic resection. @entity4 were treated with either in situ prosthetic graft or patch repairs. Operative survival was 90% for infrarenal and 57% for suprarenal infections. Operative @entity3 occurred in the setting of overwhelming @entity5 and/or severe preoperative @entity9 . There was no limb loss, @entity2 , or @entity1 . Late @entity3 occurred in 4 @entity0 at 1.3 to 6.3 years postoperatively and were unrelated to their aortic repairs. Nine @entity0 remain alive with a median follow-up of 2 years. There have been no late aortic or graft infections. CONCLUSIONS: In the absence of @entity9 and uncontrolled @entity5 , @entity11 can be successfully repaired with durable results.

title: Surgical treatment of XXXX .

answer: @entity11


abstract: The roots of Pfaffia paniculata (Brazilian @entity6 ) have been indicated for the treatment of @entity2 , among which the @entity0 . The purpose of this study was to investigate experimentally the possible antineoplastic effect of this root. Firstly, a @entity3 study was performed in which the doses of 400 and 200 mg/Kg of the powdered root were administered by gavage for 10 days to BALB/cICB @entity1 . The @entity1 did not lose weight during the treatment. No increase in serum @entity4 -aminotransferase neither histopathological alteration (liver, kidney and spleen) was observed in @entity1 treated with P. paniculata. The effect of this root on the ascitic @entity5 in BALB/cICB @entity1 was then investigated. Male @entity1 received, by gavage, once a day, 200 mg/Kg of the powdered root of P. paniculata or distilled water, as control, for 20 days. This protocol started 10 days before @entity0 inoculation with 5 x 10(6) cells i.p., and lasted until 10 days after. The @entity0 was evaluated by the quantification of the volume of the ascitic fluid, relative number of @entity0 cells and total number of @entity0 cells. A decrease in the total ascitic volume was observed in P. paniculata treated @entity1 , that was followed by a numerical decrease in the total number of @entity5 cells. These results may indicate that P. paniculata anti-inflammatory effects were responsible by the decrease in the total ascitic fluid. In addition, the presence of @entity0 -cell inhibitory factors in P. paniculata roots is in agreement with other in vitro studies. The mechanisms of such @entity0 inhibition should be further investigated.

title: Effect of Pfaffia paniculata (Brazilian @entity6 ) on the XXXX in its ascitic form.

answer: @entity5


abstract: The roots of Pfaffia paniculata (Brazilian @entity6 ) have been indicated for the treatment of @entity2 , among which the @entity0 . The purpose of this study was to investigate experimentally the possible antineoplastic effect of this root. Firstly, a @entity3 study was performed in which the doses of 400 and 200 mg/Kg of the powdered root were administered by gavage for 10 days to BALB/cICB @entity1 . The @entity1 did not lose weight during the treatment. No increase in serum @entity4 -aminotransferase neither histopathological alteration (liver, kidney and spleen) was observed in @entity1 treated with P. paniculata. The effect of this root on the ascitic @entity5 in BALB/cICB @entity1 was then investigated. Male @entity1 received, by gavage, once a day, 200 mg/Kg of the powdered root of P. paniculata or distilled water, as control, for 20 days. This protocol started 10 days before @entity0 inoculation with 5 x 10(6) cells i.p., and lasted until 10 days after. The @entity0 was evaluated by the quantification of the volume of the ascitic fluid, relative number of @entity0 cells and total number of @entity0 cells. A decrease in the total ascitic volume was observed in P. paniculata treated @entity1 , that was followed by a numerical decrease in the total number of @entity5 cells. These results may indicate that P. paniculata anti-inflammatory effects were responsible by the decrease in the total ascitic fluid. In addition, the presence of @entity0 -cell inhibitory factors in P. paniculata roots is in agreement with other in vitro studies. The mechanisms of such @entity0 inhibition should be further investigated.

title: Effect of Pfaffia paniculata (Brazilian XXXX ) on the @entity5 in its ascitic form.

answer: @entity6


abstract: Interventional radiologists have been performing image-guided spinal procedures for many years. Percutaneous vertebroplasty is a newer technique in which a medical grade cement is injected though a needle into a @entity1 . This stabilizes the @entity2 , allowing most @entity0 to discontinue or significantly decrease analgesics and resume normal activity. The impact of this procedure on the morbidity and expense associated with symptomatic @entity7 in the United States may be significant. @entity0 who are unresponsive to conservative therapy of bed rest, analgesics, and back bracing should be considered for vertebroplasty. This procedure is contraindicated in @entity0 with @entity3 , @entity4 , and certain types of @entity2 morphology. Because many @entity0 have multiple chronic @entity2 , there should be a strong correlation between the physical examination signs, symptoms, and cross-sectional imaging findings. The success rate for this procedure in treating @entity6 is 73 to 90 percent. Vertebroplasty can effectively treat aggressive @entity5 of the vertebral body and may be palliative in @entity0 with @entity2 . Significant complications of the procedure are less than 1 percent.

title: Percutaneous vertebroplasty: new treatment for XXXX .

answer: @entity7


abstract: A new procedure is developed for the extraction of @entity0 ( @entity1 ) from the particulate phase of cigarette smoke. The procedure applies solid-phase extraction using a Bond Elut CH cartridge as a sample preparation step. The efficiency of the cleanup procedure is verified using a gas chromatographic (GC)-high-resolution mass spectrometric (MS) technique, proving that no interference occurs in the @entity1 ' determination. The efficient cleanup allows GC detection using either high- or low-resolution MS detection. Enhanced sensitivity is obtained using GC-MS and selected ion monitoring. This new technique has several advantages over other reported techniques. The method is simple and robust and has good repeatability and accuracy. The estimated detection limit is 0.1 ng/cigarette for @entity2 . In addition to that, the recovery from the smoke pad in which the smoke is collected is approximately 97% for all @entity1 . Results for the PAH analyses for 1R5F, 1R4F, and 1R3 Kentucky reference cigarettes are reported in this study. These results provide useful evidence for clarifying the controversy about previously reported data.

title: Analysis of XXXX in the particulate phase of cigarette smoke using a gas chromatographic-high-resolution mass spectrometric technique.

answer: @entity0


abstract: Disorders of vascular function contribute importantly to @entity0 which represents a substantial cause of morbidity and mortality worldwide. An emerging paradigm in the study of @entity0 is that protein ubiquitination and turnover represent key pathological mechanisms. Our understanding of these processes in the vasculature is growing but remains incomplete. Since protein ubiquitination and turnover can represent a terminal event in the life of a given protein, entry into these pathways must be highly regulated. However, at present understanding of these regulatory mechanisms, particularly in the vasculature, is fragmentary. The @entity2 ( @entity2 ) signalosome (CSN) is a heteromeric protein complex implicated in the control of protein degradation. The CSN participates critically in the control of Cullin Ring Ligases (CRLs), at least in part via the detachment of a small protein, @entity1 (deneddylation). CRLs are one of the largest groups of ubiquitin ligases, which represent the most selective control point for protein ubiquitination. Thus, the CSN by virtue of its ability to control the CRLs ubiquitin ligase activity is ideally positioned to effect selective modulation of protein turnover. This review surveys currently available data regarding the potential role of the CSN in control of vascular function. Data potentially linking the CSN to control of regulatory proteins involved in vascular smooth muscle proliferation and to vascular smooth muscle contraction are presented with the intent of providing potentially intriguing possibilities for future investigation.

title: The XXXX signalosome and vascular function: intriguing possibilities?

answer: @entity2


abstract: The present study was conducted to clarify the role of @entity4 ( @entity4 ) in @entity1 after @entity0 . Transient @entity0 was induced in Mongolian gerbils by occluding the bilateral carotid arteries for 5 min. We investigated @entity4 expression in the hippocampus after @entity0 by immunohistochemistry, Northern blotting and in situ hybridization histochemistry. The results showed that @entity4 is expressed in control CAI and @entity3 neurons. In @entity2 , the amount of the @entity4 transcript immediately increased, then disappeared 2 days after @entity0 . Delayed @entity1 followed 1 day later. However, @entity4 immunoreactivity in @entity2 rapidly decreased and disappeared 12 h after transient @entity0 , proceeding to delayed @entity1 . In contrast, the expression of both @entity4 protein and the transcript was well preserved throughout the study in @entity3 , which remained viable even after @entity0 . Accordingly, the selective neuronal susceptibility in the @entity2 to @entity0 corresponded with rapid disappearance of @entity4 . @entity4 expression may contribute to neuroprotective effect after @entity0 .

title: Expression of platelet-derived growth factor after transient XXXX in the gerbil hippocampus.

answer: @entity0


abstract: This work was aimed at characterizing structural changes in primary motor cortex layer 5 pyramidal neurons and their relationship with microglial density induced by @entity3 using a @entity1 @entity6 model. Adult @entity1 , expressing green fluorescent protein in microglia and yellow fluorescent protein in projecting neurons, were submitted to either unilateral section of the facial nerve or sham surgery. Injured animals were sacrificed either 1 or 3weeks after surgery. Two-photon excitation microscopy was then used for evaluating both layer 5 pyramidal neurons and microglia in vibrissal primary motor cortex (vM1). It was found that @entity3 induced long-lasting changes in the dendritic morphology of vM1 layer 5 pyramidal neurons and in their surrounding microglia. Dendritic arborization of the pyramidal cells underwent overall shrinkage. @entity2 suffered transient @entity5 while basal dendrites displayed sustained @entity5 . Moreover, dendrites suffered transient spine pruning. Significantly higher microglial cell density was found surrounding vM1 layer 5 pyramidal neurons after @entity3 with morphological bias towards the activated phenotype. These results suggest that @entity3 elicit active dendrite remodeling due to pyramidal neuron and microglia interaction, which could be the pathophysiological underpinning of some @entity4 in @entity0 .

title: Layer 5 Pyramidal Neurons' Dendritic Remodeling and Increased Microglial Density in Primary Motor Cortex in a @entity1 Model of XXXX .

answer: @entity6


abstract: This work was aimed at characterizing structural changes in primary motor cortex layer 5 pyramidal neurons and their relationship with microglial density induced by @entity3 using a @entity1 @entity6 model. Adult @entity1 , expressing green fluorescent protein in microglia and yellow fluorescent protein in projecting neurons, were submitted to either unilateral section of the facial nerve or sham surgery. Injured animals were sacrificed either 1 or 3weeks after surgery. Two-photon excitation microscopy was then used for evaluating both layer 5 pyramidal neurons and microglia in vibrissal primary motor cortex (vM1). It was found that @entity3 induced long-lasting changes in the dendritic morphology of vM1 layer 5 pyramidal neurons and in their surrounding microglia. Dendritic arborization of the pyramidal cells underwent overall shrinkage. @entity2 suffered transient @entity5 while basal dendrites displayed sustained @entity5 . Moreover, dendrites suffered transient spine pruning. Significantly higher microglial cell density was found surrounding vM1 layer 5 pyramidal neurons after @entity3 with morphological bias towards the activated phenotype. These results suggest that @entity3 elicit active dendrite remodeling due to pyramidal neuron and microglia interaction, which could be the pathophysiological underpinning of some @entity4 in @entity0 .

title: Layer 5 Pyramidal Neurons' Dendritic Remodeling and Increased Microglial Density in Primary Motor Cortex in a XXXX Model of @entity6 .

answer: @entity1


abstract: Chemokines (chemoattractant cytokines) attract and activate specific leukocyte subsets. With regard to their expression by brain parenchymal cells, they may represent the key molecules that control leukocyte entry into the subarachnoid space. In order to evaluate the contribution of chemokines in vivo, we determined the levels of @entity3 , @entity5 , @entity4 , @entity2 , as well as of the sIL-2R in three @entity0 with proven herpes simplex @entity1 type 1 (HSE-1). CSF samples were drawn by a subarachnoid catheter system throughout the time course of hospitalisation. Results were compared to chemokine levels in serum drawn in parallel. The clinical status was documented by the Modified Barthel Index and correlated with chemokine levels in the CSF. The results were compared with the chemokine levels in the CSF of 17 control @entity0 with normal CSF routine parameters. High chemokine levels were detectable in the CSF of all HSE- @entity0 . @entity3 peak levels were found at the time of admission, while maximal @entity2 levels occurred 4 to 8 h later. The levels of @entity5 and @entity4 were lower than those of @entity3 with a maximum at the time of admission. In all @entity0 the levels of the sIL-2R increased later in the time course, at 14 to 20 h after admission. When the levels of @entity3 were compared with the clinical status by Modified Barthel Index, we found a high reciprocal correlation (r=-0.82). Routine CSF parameters, such as leukocytes, albumin and immunoglobulins did not correlate with the clinical status. Chemokine levels in serum were found to be close to the detection limits of the ELISA systems. Our data suggest that chemokines play an important role in the pathogenesis of HSE. They may be useful parameters to monitor the stage and severity of the disease. The late increase of sIL2-R levels may indicate the beginning of the reconstitution phase.

title: Time course of chemokines in the cerebrospinal fluid and serum during herpes simplex type 1 XXXX .

answer: @entity1


abstract: The recurrent cytogenetic (CG) abnormality t(14;19)(q32;q13) involving the oncogene @entity10 is described in @entity0 with atypical @entity4 ( @entity4 ). We report four @entity0 with @entity5 ( @entity5 ) bearing t(14;19). All cases were female and their age ranged from 62 to 91. Histologically, there were two cases of @entity4 ( @entity4 ), both @entity7 positive with atypical morphology, one case of @entity6 ( @entity6 ), and one case of @entity8 ( @entity8 ). One @entity4 @entity0 showed t(14;19) as the sole abnormality and experienced a benign course for 8 years. The other three cases showed secondary CG progression, including tetraploidy, del(6q), t(8;22) and del(13q). These cases were @entity2 in clinical behavior, including an @entity4 case which transformed to @entity3 in 4 months. Southern analysis and long distance PCR confirmed @entity10 / @entity9 Calpha translocation in one case. We propose that NHLs with t(14;19) may have evolved from the same spectrum of disease as @entity4 . The poor prognosis of @entity1 is associated with the occurrence of recurrent secondary CG changes, commonly found in B cell lymphoproliferative diseases.

title: XXXX / @entity9 translocation (14;19)(q32;q13) in @entity5 .

answer: @entity10


abstract: The recurrent cytogenetic (CG) abnormality t(14;19)(q32;q13) involving the oncogene @entity10 is described in @entity0 with atypical @entity4 ( @entity4 ). We report four @entity0 with @entity5 ( @entity5 ) bearing t(14;19). All cases were female and their age ranged from 62 to 91. Histologically, there were two cases of @entity4 ( @entity4 ), both @entity7 positive with atypical morphology, one case of @entity6 ( @entity6 ), and one case of @entity8 ( @entity8 ). One @entity4 @entity0 showed t(14;19) as the sole abnormality and experienced a benign course for 8 years. The other three cases showed secondary CG progression, including tetraploidy, del(6q), t(8;22) and del(13q). These cases were @entity2 in clinical behavior, including an @entity4 case which transformed to @entity3 in 4 months. Southern analysis and long distance PCR confirmed @entity10 / @entity9 Calpha translocation in one case. We propose that NHLs with t(14;19) may have evolved from the same spectrum of disease as @entity4 . The poor prognosis of @entity1 is associated with the occurrence of recurrent secondary CG changes, commonly found in B cell lymphoproliferative diseases.

title: @entity10 / @entity9 translocation (14;19)(q32;q13) in XXXX .

answer: @entity5


abstract: The recurrent cytogenetic (CG) abnormality t(14;19)(q32;q13) involving the oncogene @entity10 is described in @entity0 with atypical @entity4 ( @entity4 ). We report four @entity0 with @entity5 ( @entity5 ) bearing t(14;19). All cases were female and their age ranged from 62 to 91. Histologically, there were two cases of @entity4 ( @entity4 ), both @entity7 positive with atypical morphology, one case of @entity6 ( @entity6 ), and one case of @entity8 ( @entity8 ). One @entity4 @entity0 showed t(14;19) as the sole abnormality and experienced a benign course for 8 years. The other three cases showed secondary CG progression, including tetraploidy, del(6q), t(8;22) and del(13q). These cases were @entity2 in clinical behavior, including an @entity4 case which transformed to @entity3 in 4 months. Southern analysis and long distance PCR confirmed @entity10 / @entity9 Calpha translocation in one case. We propose that NHLs with t(14;19) may have evolved from the same spectrum of disease as @entity4 . The poor prognosis of @entity1 is associated with the occurrence of recurrent secondary CG changes, commonly found in B cell lymphoproliferative diseases.

title: @entity10 / XXXX translocation (14;19)(q32;q13) in @entity5 .

answer: @entity9


abstract: OBJECTIVE: To examine the occurrence of @entity10 after cardioversion of @entity6 . METHODS: Cases, case series, and related articles on the subject identified through a comprehensive literature search were examined. RESULTS: Thirty cases (23 males) of post cardioversion @entity10 were identified. The mean age was 53.8 +/- 13 years (range, 18 to 75 years). Underlying @entity6 were @entity7 (69%), @entity8 (24%), @entity11 (4%), and @entity9 (4%). The duration of @entity6 preceding cardioversion varied widely ranging from 1 day to 13 years. Twenty-six (87%) @entity0 had concomitant @entity1 comprising of @entity5 (38%), @entity12 (23%), @entity3 (23%), and @entity2 (8%). Direct current electrical cardioversion was used in 28 (93%) @entity0 and pacing in two (7%) @entity0 . Occurrence of @entity10 was independent of the amount of energy used for cardioversion (range 20 to 1280 Joules, mean 263 +/- 27 Joules). Short acting general anesthetic drugs were administered in 14 (47%) and sedation in eight (27%) @entity0 . Sinus rhythm was established in 23 (77%) @entity0 . Duration to develop @entity10 after cardioversion was available in 23 @entity0 and ranged from immediately to 96 h. @entity10 occurred within 15 min after cardioversion in 22%, within 3 h in 30%, within 24 h in 30%, within 48 h in 17% and within 96 h in remaining 4% of @entity0 . Three @entity0 required mechanical ventilation. CONCLUSION: The rare complication of @entity10 after cardioversion has been reported mostly in @entity0 with underlying @entity4 , and is independent of the amount of energy used for cardioversion.

title: @entity10 after cardioversion of XXXX .

answer: @entity6


abstract: OBJECTIVE: To examine the occurrence of @entity10 after cardioversion of @entity6 . METHODS: Cases, case series, and related articles on the subject identified through a comprehensive literature search were examined. RESULTS: Thirty cases (23 males) of post cardioversion @entity10 were identified. The mean age was 53.8 +/- 13 years (range, 18 to 75 years). Underlying @entity6 were @entity7 (69%), @entity8 (24%), @entity11 (4%), and @entity9 (4%). The duration of @entity6 preceding cardioversion varied widely ranging from 1 day to 13 years. Twenty-six (87%) @entity0 had concomitant @entity1 comprising of @entity5 (38%), @entity12 (23%), @entity3 (23%), and @entity2 (8%). Direct current electrical cardioversion was used in 28 (93%) @entity0 and pacing in two (7%) @entity0 . Occurrence of @entity10 was independent of the amount of energy used for cardioversion (range 20 to 1280 Joules, mean 263 +/- 27 Joules). Short acting general anesthetic drugs were administered in 14 (47%) and sedation in eight (27%) @entity0 . Sinus rhythm was established in 23 (77%) @entity0 . Duration to develop @entity10 after cardioversion was available in 23 @entity0 and ranged from immediately to 96 h. @entity10 occurred within 15 min after cardioversion in 22%, within 3 h in 30%, within 24 h in 30%, within 48 h in 17% and within 96 h in remaining 4% of @entity0 . Three @entity0 required mechanical ventilation. CONCLUSION: The rare complication of @entity10 after cardioversion has been reported mostly in @entity0 with underlying @entity4 , and is independent of the amount of energy used for cardioversion.

title: XXXX after cardioversion of @entity6 .

answer: @entity10


abstract: Plasma levels of phospholipids, @entity2 , high density lipoproteins (HDL)- @entity0 and HDL-phospholipids were studied in 48 11-d-old female mule @entity3 infected per os with 5 x 10(3) x 10(4) x 5 x 10(5) sporulated oocysts of Eimeria mulardi (D0), or kept as an uninfected control group. Data were recorded from D-1 to D17. Mortality and weight loss were only observed with the 5 x 10(5) oocyst dose. Plasma phospholipids were significantly reduced with the two highest infecting doses on D3, and returned to normal values by D9 with the highest infecting dose. The minimum level attained was no lower than 74% of the control group. @entity1 levels were reduced early but only slightly and irregularly in the three infected groups. HDL- @entity0 was significantly reduced from D5 and HDL-phospholipids from D3. These reduced levels depended on the infecting dose and were lowest on D5, respectively 34 and 35% of the control group with the highest infecting dose. In this group, the levels remained lower than in the uninfected group on D17. These perturbations in blood lipid classes have been described in @entity4 .

title: Plasma lipid changes in the female mule XXXX (Cairina moschata x @entity3 ) experimentally infected with Eimeria mulardi.

answer: @entity3


abstract: Plasma levels of phospholipids, @entity2 , high density lipoproteins (HDL)- @entity0 and HDL-phospholipids were studied in 48 11-d-old female mule @entity3 infected per os with 5 x 10(3) x 10(4) x 5 x 10(5) sporulated oocysts of Eimeria mulardi (D0), or kept as an uninfected control group. Data were recorded from D-1 to D17. Mortality and weight loss were only observed with the 5 x 10(5) oocyst dose. Plasma phospholipids were significantly reduced with the two highest infecting doses on D3, and returned to normal values by D9 with the highest infecting dose. The minimum level attained was no lower than 74% of the control group. @entity1 levels were reduced early but only slightly and irregularly in the three infected groups. HDL- @entity0 was significantly reduced from D5 and HDL-phospholipids from D3. These reduced levels depended on the infecting dose and were lowest on D5, respectively 34 and 35% of the control group with the highest infecting dose. In this group, the levels remained lower than in the uninfected group on D17. These perturbations in blood lipid classes have been described in @entity4 .

title: Plasma lipid changes in the female mule @entity3 (Cairina moschata x XXXX ) experimentally infected with Eimeria mulardi.

answer: @entity3


abstract: 9356 cases of @entity1 were reported in Mexico through March 1992. Although 7971 were in @entity0 and 1385 in @entity0 , the ratio of male to female cases has declined. In 1985, 1 @entity0 was infected for every 20 @entity0 , but by 1991 the proportion was 1 for every 5. The annual numbers of reported cases through 1992 indicate that the epidemic is abating, but reporting of @entity1 cases may be delayed for up to 4 years in Mexico. The groups considered at greatest risk of @entity1 have changed over time. The proportion of new cases in homosexuals has declined from 80% in the early 1980s to 40% at present. Heterosexually transmitted cases now account for around 23%. Another 17% are transmitted parenterally through transfusions or use of contaminated needles by addicts. The homosexual population has become aware of the danger, but greater attention to prevention is required for the general heterosexual population. Cases are concentrated in the Federal District, which has a rate of 30/100,000. Four states, Baja California, Jalisco, Morelos, and Yucatan, have rates of over 10/100,000, and rates in 10 states exceed 5/100,000. The mean age of reported cases @entity2 years.

title: [ XXXX : the risk that must be predicted].

answer: @entity1


abstract: Studies were undertaken to characterize and determine the pathogenic mechanisms involved in a newly described @entity1 in @entity6 ( @entity6 ) caused by a @entity7 -like microorganism. Nineteen isolates were obtained from eight of nine lobsters sampled. Biochemically, the isolates resembled @entity7 , and the isolates grew optimally at 20 degrees C; none could grow at temperatures above 23 degrees C. The type strain (1AMA) displayed a thermal reduction time (D value) of 5.77 min at 37 degrees C. All of the isolates required at least 1% @entity4 for growth. Collectively, the data suggest that these isolates may embody a new biotype. Pulsed-field gel electrophoresis (PFGE) analysis of the isolates revealed five closely related subgroups. Some isolates produced a @entity3 hemagglutinin that was neither an outer membrane protein nor a metalloprotease. Several isolates possessed capsules. The isolates were highly susceptible to a variety of antibiotics tested. However, six isolates were resistant to @entity5 . Seventeen isolates harbored plasmids. Lobster challenge studies revealed that the 50% lethal dose of a plasmid-positive strain was 100-fold lower than that of a plasmid-negative strain, suggesting that the plasmid may enhance the pathogenicity of these microorganisms in lobsters. Microorganisms that were recovered from experimentally infected lobsters exhibited biochemical and PFGE profiles that were indistinguishable from those of the challenge strain. Tissue affinity studies demonstrated that the challenge microorganisms accumulated in heart and midgut tissues as well as in the hemolymph. Culture supernatants and polymyxin B lysates of the strains caused elongation of CHO cells in tissue culture, suggesting the presence of a hitherto unknown enterotoxin. Both plasmid-positive and plasmid-negative strains caused significant dose-related intestinal fluid accumulations in suckling @entity0 . Absence of viable organisms in the intestinal contents of @entity0 suggests that these microorganisms cause @entity2 in @entity0 by intoxication rather than by an infectious process. Further, these results support the thermal reduction data at 37 degrees C and suggest that the mechanism(s) that led to fluid accumulation in @entity0 differs from the disease process observed in lobsters by requiring neither the persistence of viable microorganisms nor the presence of plasmids. In summary, results of lobster studies satisfy Koch's postulates at the organismal and molecular levels; the findings support the hypothesis that these @entity7 -like organisms were responsible for the originally described @entity1 , which is now called limp lobster disease.

title: Characterization of XXXX -like strains implicated in limp lobster disease.

answer: @entity7


abstract: OBJECTIVE: To prospectively evaluate the accuracy of a multiparameter, ultrasound-based triage and its impact on surgical management of @entity3 . METHODS: Masses evaluated as normal according to Ferrazzi's sonographic morphological score were considered as being at low risk of @entity1 and eligible for laparoscopic treatment without further evaluation. Masses evaluated as abnormal, but without additional risk factors such as ascites, diameter > or = 10 cm, bilaterality, immobility, resistance index < or = 0.6 and serum @entity4 > 35 IU/mL were considered at moderate risk and eligible for laparoscopic evaluation and treatment. Masses with abnormal morphological score and any of these additional risk factors were considered at high risk and treated by laparotomy. The results of pathological examination were obtained for each mass. RESULTS: Two hundred and four (87%) masses were benign and 30 (13%) were malignant. Among 182 low-risk, 19 moderate-risk and 33 high-risk masses, the odds of @entity1 were 1 : 90, 1 : 18 and 4.5 : 1, respectively. To calculate the diagnostic accuracy of this algorithm, low- and moderate-risk groups were considered together: the sensitivity was 90%, specificity 97%, positive predictive value 82% and negative predictive value 99%. The new algorithm was significantly more accurate than was morphological score alone (P = 0.0002). Ninety-six percent of benign masses were treated by laparoscopy. All three @entity0 with malignant masses that were incorrectly assigned to laparoscopy underwent laparoscopic adnexectomy and frozen section. CONCLUSIONS: The accuracy of this new algorithm was higher than that of the sonographic morphological scoring system alone. In the present series, it allowed the treatment by laparoscopy of 96% of benign @entity3 without mismanagement of any cases of @entity2 .

title: Impact of a multiparameter, ultrasound-based triage on surgical management of XXXX .

answer: @entity3


abstract: OBJECTIVE: To evaluate the ability of a prediction model to identify the individual @entity3 dose of FSH for ovulation induction using a step-down regimen. DESIGN: Retrospective analysis of clinical data in an academic fertility unit. Fifty-six normogonadotropic @entity1 @entity0 who failed to ovulate or conceive with @entity4 were included. They were treated with exogenous gonadotropins with a flexible @entity3 dose for ovulation induction using a step-down regimen. The clinically applied @entity3 dose of exogenous gonadotropins was compared with the calculated response-dose using a previously published prediction model. RESULTS: @entity0 were arbitrarily divided into three groups according to the day of the first decrease in gonadotropin dose: (a) early step-down (day 3 or earlier); (b) standard step-down (day 4 or later); (c) no step-down. These groups had average @entity3 doses of 28.5 IU (group a) and 13 IU (group b) above the calculated response-dose, and 43 IU (group c) under the calculated response-dose. A significant correlation between day of first step-down and the difference between clinically applied and calculated response-dose was observed (P<0.0001, F-test for ANOVA). CONCLUSIONS: The @entity0 group with the best step-down profile for ovulation induction exhibited the closest match between the clinically applied and calculated @entity3 dose of gonadotropins. Therefore, this study provides support for the concept that the individual effective FSH @entity3 dose for gonadotropin induction of ovulation in @entity1 @entity0 can be predicted on the basis of initial screening characteristics, such as body mass index, @entity4 resistance or failure, free @entity2 and FSH. This may result in more effective @entity0 treatment protocols, reduced complication rates and health-economic benefits.

title: FSH response-dose can be predicted in ovulation induction for normogonadotropic XXXX .

answer: @entity1


abstract: OBJECTIVE: In @entity0 with @entity1 , information processing deficits, such as those reported in studies that measured prepulse inhibition of the @entity0 @entity2 response and @entity4 of @entity2 magnitude, may be improved with atypical antipsychotic treatment. However, it remains unclear whether antipsychotic medication is directly responsible for the improvement or whether differences in prepulse inhibition reflect other factors, such as acuity status. The present study investigated the effects of antipsychotics on prepulse inhibition and @entity2 in acutely hospitalized @entity0 with @entity1 . METHOD: Forty-one acutely @entity3 @entity1 @entity0 (21 who were unmedicated at the time of admission and 20 who had been receiving antipsychotic treatment) were tested within 72 hours of hospital admission. Thirteen healthy subjects were also studied for comparative purposes. Primary dependent measures were @entity2 responsivity, reactivity, prepulse inhibition, and @entity2 . RESULTS: @entity1 @entity0 , whether medicated or unmedicated at admission, showed prepulse inhibition deficits compared with healthy subjects and did not statistically differ from each other in @entity2 magnitude, prepulse inhibition, or @entity4 . There was a higher number of @entity2 "nonresponders" among those who had been receiving medication versus those unmedicated at the time of admission. CONCLUSIONS: The present findings suggest that antipsychotic effects on prepulse inhibition may not be evident at a time when @entity1 @entity0 are acutely symptomatic. These results suggest that the neurobiological substrate underlying prepulse inhibition deficits may be dysregulated during acute @entity3 states while the @entity0 are in early phases of medication treatment.

title: Information processing deficits in acutely @entity3 XXXX @entity0 medicated and unmedicated at the time of admission.

answer: @entity1


abstract: OBJECTIVE: In @entity0 with @entity1 , information processing deficits, such as those reported in studies that measured prepulse inhibition of the @entity0 @entity2 response and @entity4 of @entity2 magnitude, may be improved with atypical antipsychotic treatment. However, it remains unclear whether antipsychotic medication is directly responsible for the improvement or whether differences in prepulse inhibition reflect other factors, such as acuity status. The present study investigated the effects of antipsychotics on prepulse inhibition and @entity2 in acutely hospitalized @entity0 with @entity1 . METHOD: Forty-one acutely @entity3 @entity1 @entity0 (21 who were unmedicated at the time of admission and 20 who had been receiving antipsychotic treatment) were tested within 72 hours of hospital admission. Thirteen healthy subjects were also studied for comparative purposes. Primary dependent measures were @entity2 responsivity, reactivity, prepulse inhibition, and @entity2 . RESULTS: @entity1 @entity0 , whether medicated or unmedicated at admission, showed prepulse inhibition deficits compared with healthy subjects and did not statistically differ from each other in @entity2 magnitude, prepulse inhibition, or @entity4 . There was a higher number of @entity2 "nonresponders" among those who had been receiving medication versus those unmedicated at the time of admission. CONCLUSIONS: The present findings suggest that antipsychotic effects on prepulse inhibition may not be evident at a time when @entity1 @entity0 are acutely symptomatic. These results suggest that the neurobiological substrate underlying prepulse inhibition deficits may be dysregulated during acute @entity3 states while the @entity0 are in early phases of medication treatment.

title: Information processing deficits in acutely XXXX @entity1 @entity0 medicated and unmedicated at the time of admission.

answer: @entity3


abstract: OBJECTIVE: In @entity0 with @entity1 , information processing deficits, such as those reported in studies that measured prepulse inhibition of the @entity0 @entity2 response and @entity4 of @entity2 magnitude, may be improved with atypical antipsychotic treatment. However, it remains unclear whether antipsychotic medication is directly responsible for the improvement or whether differences in prepulse inhibition reflect other factors, such as acuity status. The present study investigated the effects of antipsychotics on prepulse inhibition and @entity2 in acutely hospitalized @entity0 with @entity1 . METHOD: Forty-one acutely @entity3 @entity1 @entity0 (21 who were unmedicated at the time of admission and 20 who had been receiving antipsychotic treatment) were tested within 72 hours of hospital admission. Thirteen healthy subjects were also studied for comparative purposes. Primary dependent measures were @entity2 responsivity, reactivity, prepulse inhibition, and @entity2 . RESULTS: @entity1 @entity0 , whether medicated or unmedicated at admission, showed prepulse inhibition deficits compared with healthy subjects and did not statistically differ from each other in @entity2 magnitude, prepulse inhibition, or @entity4 . There was a higher number of @entity2 "nonresponders" among those who had been receiving medication versus those unmedicated at the time of admission. CONCLUSIONS: The present findings suggest that antipsychotic effects on prepulse inhibition may not be evident at a time when @entity1 @entity0 are acutely symptomatic. These results suggest that the neurobiological substrate underlying prepulse inhibition deficits may be dysregulated during acute @entity3 states while the @entity0 are in early phases of medication treatment.

title: Information processing deficits in acutely @entity3 @entity1 XXXX medicated and unmedicated at the time of admission.

answer: @entity0


abstract: OBJECTIVE: Association of @entity3 ( @entity3 ) gene polymorphism with susceptibility to @entity0 have been investigated in a number of epidemiological studies, but the results are inclusive. The aim of this meta-analysis was to more precisely estimate the relationship. METHODS: The databases of Pubmed and CBM updated to October, 2014 were retrieved. Random- or fixed-effect model was used to estimate odd radio (OR) and corresponding 95% confidence interval (95%CI) on the basis of heterogeneity. RESULTS: Seven articles containing 2196 @entity1 ( @entity1 ) cases, 1588 @entity2 ( @entity2 ) cases and 4126 controls were identified. We detected a significant association between @entity3 @entity4 polymorphism and IBD susceptibility in overall population (GG vs. GT+TT, OR=0.855, 95%  CI=0.760-0.962, P=0.009), but not in Caucasian and Asian population, respectively. No association was detected between @entity4 polymorphism and @entity1 susceptibility in overall, Asian and Caucasian population, respectively. Interestingly, a significant association was detected between @entity4 with @entity2 susceptibility in overall population (G vs. T, OR=0.881, 95%  CI=0.798-0.972, P=0.012; GG vs. GT+TT, OR=0.788, 95%  CI=0.679-0.914, P=0.002; GG vs. TT, OR=0.683, 95%  CI=0.498-0.937, P=0.018) and Caucasians (GG vs. GT+TT, OR=0.833, 95%  CI=0.701-0.990, P=0.038; GG+GT vs. TT, OR=0.667, 95%  CI=0.456-0.975, P=0.037; GG vs. TT, OR=0.636, 95%  CI=0.433-0.934, P=0.021), respectively, and a possible association was found in Asian population (GG vs. GT+TT, OR=0.709, 95%  CI=0.503-0.998, P=0.049). CONCLUSIONS: @entity3 @entity4 gene is IBD risk factor, and this gene polymorphism is associated with @entity2 susceptibility, especially in Caucasians. To confirm these findings, further studies with more sample size are required for a definitive conclusion.

title: Association of XXXX @entity4 polymorphism with susceptibility to @entity0 : A systematic review and meta-analysis.

answer: @entity3


abstract: OBJECTIVE: Association of @entity3 ( @entity3 ) gene polymorphism with susceptibility to @entity0 have been investigated in a number of epidemiological studies, but the results are inclusive. The aim of this meta-analysis was to more precisely estimate the relationship. METHODS: The databases of Pubmed and CBM updated to October, 2014 were retrieved. Random- or fixed-effect model was used to estimate odd radio (OR) and corresponding 95% confidence interval (95%CI) on the basis of heterogeneity. RESULTS: Seven articles containing 2196 @entity1 ( @entity1 ) cases, 1588 @entity2 ( @entity2 ) cases and 4126 controls were identified. We detected a significant association between @entity3 @entity4 polymorphism and IBD susceptibility in overall population (GG vs. GT+TT, OR=0.855, 95%  CI=0.760-0.962, P=0.009), but not in Caucasian and Asian population, respectively. No association was detected between @entity4 polymorphism and @entity1 susceptibility in overall, Asian and Caucasian population, respectively. Interestingly, a significant association was detected between @entity4 with @entity2 susceptibility in overall population (G vs. T, OR=0.881, 95%  CI=0.798-0.972, P=0.012; GG vs. GT+TT, OR=0.788, 95%  CI=0.679-0.914, P=0.002; GG vs. TT, OR=0.683, 95%  CI=0.498-0.937, P=0.018) and Caucasians (GG vs. GT+TT, OR=0.833, 95%  CI=0.701-0.990, P=0.038; GG+GT vs. TT, OR=0.667, 95%  CI=0.456-0.975, P=0.037; GG vs. TT, OR=0.636, 95%  CI=0.433-0.934, P=0.021), respectively, and a possible association was found in Asian population (GG vs. GT+TT, OR=0.709, 95%  CI=0.503-0.998, P=0.049). CONCLUSIONS: @entity3 @entity4 gene is IBD risk factor, and this gene polymorphism is associated with @entity2 susceptibility, especially in Caucasians. To confirm these findings, further studies with more sample size are required for a definitive conclusion.

title: Association of @entity3 XXXX polymorphism with susceptibility to @entity0 : A systematic review and meta-analysis.

answer: @entity4


abstract: OBJECTIVE: Association of @entity3 ( @entity3 ) gene polymorphism with susceptibility to @entity0 have been investigated in a number of epidemiological studies, but the results are inclusive. The aim of this meta-analysis was to more precisely estimate the relationship. METHODS: The databases of Pubmed and CBM updated to October, 2014 were retrieved. Random- or fixed-effect model was used to estimate odd radio (OR) and corresponding 95% confidence interval (95%CI) on the basis of heterogeneity. RESULTS: Seven articles containing 2196 @entity1 ( @entity1 ) cases, 1588 @entity2 ( @entity2 ) cases and 4126 controls were identified. We detected a significant association between @entity3 @entity4 polymorphism and IBD susceptibility in overall population (GG vs. GT+TT, OR=0.855, 95%  CI=0.760-0.962, P=0.009), but not in Caucasian and Asian population, respectively. No association was detected between @entity4 polymorphism and @entity1 susceptibility in overall, Asian and Caucasian population, respectively. Interestingly, a significant association was detected between @entity4 with @entity2 susceptibility in overall population (G vs. T, OR=0.881, 95%  CI=0.798-0.972, P=0.012; GG vs. GT+TT, OR=0.788, 95%  CI=0.679-0.914, P=0.002; GG vs. TT, OR=0.683, 95%  CI=0.498-0.937, P=0.018) and Caucasians (GG vs. GT+TT, OR=0.833, 95%  CI=0.701-0.990, P=0.038; GG+GT vs. TT, OR=0.667, 95%  CI=0.456-0.975, P=0.037; GG vs. TT, OR=0.636, 95%  CI=0.433-0.934, P=0.021), respectively, and a possible association was found in Asian population (GG vs. GT+TT, OR=0.709, 95%  CI=0.503-0.998, P=0.049). CONCLUSIONS: @entity3 @entity4 gene is IBD risk factor, and this gene polymorphism is associated with @entity2 susceptibility, especially in Caucasians. To confirm these findings, further studies with more sample size are required for a definitive conclusion.

title: Association of @entity3 @entity4 polymorphism with susceptibility to XXXX : A systematic review and meta-analysis.

answer: @entity0


abstract: ACE inhibition protects the heart against @entity1 by reducing @entity4 and promoting @entity6 (BK) accumulation. Since neutral endopeptidase ( @entity8 ) metabolizes BK, we determined its activity after induction of @entity2 ( @entity2 ) and examined whether it is influenced by treatment with an ACE inhibitor or @entity5 receptor blocker. @entity0 were studied 6 days and 3 wk after @entity3 . Starting 48 h after @entity2 induction, additional animals were treated with the ACE inhibitor @entity9 (2 mg x kg(-1) x day-1) or the @entity5 blocker @entity7 (50 mg x kg(-1) x day-1). Animals were hemodynamically characterized. Finally, @entity8 -specific activity and BK concentrations were detected in homogenates of heart compartments. @entity9 and @entity7 treatment improved left ventricular function 6 days and 3 wk after @entity2 induction, and @entity8 activity was elevated only in the infarcted area of untreated compared with sham-operated @entity0 . After 6 days, @entity7 reversed this increase by 80% and @entity9 by 35%. @entity9 had no effect after 3 wk, whereas @entity7 almost completely blocked the increased @entity8 activity in the infarcted area and concomitantly induced a further rise in the BK concentrations. These results indicate mechanisms of @entity8 regulation influenced by the @entity5 receptor. Our data suggest that @entity8 is more decisive than ACE in mediating BK degradation and may indicate BK involvement in the cardioprotective effects of @entity5 antagonists.

title: XXXX receptor blockade increases cardiac @entity6 via neutral endopeptidase after induction of @entity2 in @entity0 .

answer: @entity5


abstract: ACE inhibition protects the heart against @entity1 by reducing @entity4 and promoting @entity6 (BK) accumulation. Since neutral endopeptidase ( @entity8 ) metabolizes BK, we determined its activity after induction of @entity2 ( @entity2 ) and examined whether it is influenced by treatment with an ACE inhibitor or @entity5 receptor blocker. @entity0 were studied 6 days and 3 wk after @entity3 . Starting 48 h after @entity2 induction, additional animals were treated with the ACE inhibitor @entity9 (2 mg x kg(-1) x day-1) or the @entity5 blocker @entity7 (50 mg x kg(-1) x day-1). Animals were hemodynamically characterized. Finally, @entity8 -specific activity and BK concentrations were detected in homogenates of heart compartments. @entity9 and @entity7 treatment improved left ventricular function 6 days and 3 wk after @entity2 induction, and @entity8 activity was elevated only in the infarcted area of untreated compared with sham-operated @entity0 . After 6 days, @entity7 reversed this increase by 80% and @entity9 by 35%. @entity9 had no effect after 3 wk, whereas @entity7 almost completely blocked the increased @entity8 activity in the infarcted area and concomitantly induced a further rise in the BK concentrations. These results indicate mechanisms of @entity8 regulation influenced by the @entity5 receptor. Our data suggest that @entity8 is more decisive than ACE in mediating BK degradation and may indicate BK involvement in the cardioprotective effects of @entity5 antagonists.

title: @entity5 receptor blockade increases cardiac XXXX via neutral endopeptidase after induction of @entity2 in @entity0 .

answer: @entity6


abstract: ACE inhibition protects the heart against @entity1 by reducing @entity4 and promoting @entity6 (BK) accumulation. Since neutral endopeptidase ( @entity8 ) metabolizes BK, we determined its activity after induction of @entity2 ( @entity2 ) and examined whether it is influenced by treatment with an ACE inhibitor or @entity5 receptor blocker. @entity0 were studied 6 days and 3 wk after @entity3 . Starting 48 h after @entity2 induction, additional animals were treated with the ACE inhibitor @entity9 (2 mg x kg(-1) x day-1) or the @entity5 blocker @entity7 (50 mg x kg(-1) x day-1). Animals were hemodynamically characterized. Finally, @entity8 -specific activity and BK concentrations were detected in homogenates of heart compartments. @entity9 and @entity7 treatment improved left ventricular function 6 days and 3 wk after @entity2 induction, and @entity8 activity was elevated only in the infarcted area of untreated compared with sham-operated @entity0 . After 6 days, @entity7 reversed this increase by 80% and @entity9 by 35%. @entity9 had no effect after 3 wk, whereas @entity7 almost completely blocked the increased @entity8 activity in the infarcted area and concomitantly induced a further rise in the BK concentrations. These results indicate mechanisms of @entity8 regulation influenced by the @entity5 receptor. Our data suggest that @entity8 is more decisive than ACE in mediating BK degradation and may indicate BK involvement in the cardioprotective effects of @entity5 antagonists.

title: @entity5 receptor blockade increases cardiac @entity6 via neutral endopeptidase after induction of XXXX in @entity0 .

answer: @entity2


abstract: ACE inhibition protects the heart against @entity1 by reducing @entity4 and promoting @entity6 (BK) accumulation. Since neutral endopeptidase ( @entity8 ) metabolizes BK, we determined its activity after induction of @entity2 ( @entity2 ) and examined whether it is influenced by treatment with an ACE inhibitor or @entity5 receptor blocker. @entity0 were studied 6 days and 3 wk after @entity3 . Starting 48 h after @entity2 induction, additional animals were treated with the ACE inhibitor @entity9 (2 mg x kg(-1) x day-1) or the @entity5 blocker @entity7 (50 mg x kg(-1) x day-1). Animals were hemodynamically characterized. Finally, @entity8 -specific activity and BK concentrations were detected in homogenates of heart compartments. @entity9 and @entity7 treatment improved left ventricular function 6 days and 3 wk after @entity2 induction, and @entity8 activity was elevated only in the infarcted area of untreated compared with sham-operated @entity0 . After 6 days, @entity7 reversed this increase by 80% and @entity9 by 35%. @entity9 had no effect after 3 wk, whereas @entity7 almost completely blocked the increased @entity8 activity in the infarcted area and concomitantly induced a further rise in the BK concentrations. These results indicate mechanisms of @entity8 regulation influenced by the @entity5 receptor. Our data suggest that @entity8 is more decisive than ACE in mediating BK degradation and may indicate BK involvement in the cardioprotective effects of @entity5 antagonists.

title: @entity5 receptor blockade increases cardiac @entity6 via neutral endopeptidase after induction of @entity2 in XXXX .

answer: @entity0


abstract: The involvement of inhibin in the decline of the secondary surge of follicle-stimulating hormone (FSH) was investigated in the @entity0 . After ovariectomy or treatment with inhibin antiserum conducted at 2300 hours during pro-oestrus, plasma concentrations of FSH were maintained at high levels compared with control @entity0 . However, plasma FSH started to decline at 0500 hours during oestrus in both the groups. The same treatments conducted during metoestrus markedly increased plasma FSH after 24 h (twofold compared with the treatments during pro-oestrus), suggesting that the treatments sufficiently depleted circulating inhibin. To examine whether the decline of plasma FSH occurred through a transcriptional mechanism or through a translational mechanism, @entity1 mRNA expression and the pituitary concentration of FSH were measured. Neither ovariectomy nor inhibin immunization conducted during the night of pro-oestrus, affected the pituitary concentration of FSH after 24 h, whereas a noticeable increase was observed after the treatments conducted during metoestrus. In both stages, both ovariectomy and inhibin immunization significantly increased @entity1 mRNA expression compared with control @entity0 . In contrast with the pituitary concentration of FSH, the effect of inhibin immunization on @entity1 mRNA expression was not different between the stages. The present data demonstrate the involvement of inhibin in the decline of the secondary surge of FSH, and suggest that a factor or factors other than inhibin may also be responsible for the fall in FSH. Changes in the pituitary concentration of FSH and @entity1 mRNA expression suggest that post-transcriptional mechanisms may be involved in the suppression of FSH secretion during oestrus.

title: Contribution of endogenous inhibin to the decline of the secondary surge of follicle-stimulating hormone in the XXXX .

answer: @entity0


abstract: BACKGROUND: The @entity2 exhibits important differences in anatomical distribution, histologic appearance and radiographic findings compared with the classic type of @entity2 . The purpose of this article is to assist the dental community in better understanding this variation in @entity0 . CASE DESCRIPTIONS: The authors present two cases of @entity2 localized in the anterior portion of the jaw. The @entity0 were expansile, destructive and painless. The radiographic findings showed diffuse, mixed (radiopaque/radiolucent) lesions with cortical @entity1 . Block excision was performed in both cases. Follow-up examination one and two years later disclosed no recurrence of @entity0 . CLINICAL IMPLICATIONS: The @entity2 tends to infiltrate between bone trabeculae. Curettage leaves islands of @entity0 within bone, which later manifest as recurrences. Therefore, block excision is the most widely used treatment to avoid recurrence.

title: XXXX : report of two cases and review of the literature.

answer: @entity2


abstract: AIM: To describe the age at onset, recurrence rate, and provision of care for @entity0 with @entity2 in New Zealand. METHODS: Between 1997 and 1998, @entity0 with current @entity2 were identified from the North Auckland and Central Auckland health districts via notification from relevant health professionals and by self-referral. All @entity1 types were investigated. Identified cases, aged between 40 and 99 years and on the general electoral roll, were interviewed as part of a case-control study. Descriptive information relating to interviewed cases is presented. RESULTS: 241 @entity0 with @entity2 were interviewed. The average age was 75 years and almost 60% were @entity0 . The average age at @entity1 onset was 65 years, 59% of @entity0 had recurrent @entity1 , and 24% had been hospitalised in the last five years because of their @entity2 . Those @entity0 with recurrent @entity2 had lived with their condition for an average of fifteen years, with an average time to healing for their last @entity1 of thirteen months. Treatment of this condition was largely community-based, with 136 different treatment options employed. CONCLUSIONS: Leg ulceration remains a chronic and recurring condition, with substantial practice variation in terms of treatment. Urgent attention needs to be given to the management of leg @entity1 @entity0 in this country, particularly given that New Zealand has a rapidly ageing population.

title: XXXX in New Zealand: age at onset, recurrence and provision of care in an urban population.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: For more widespread clinical use advanced imaging methods such as relative cerebral blood volume must be both accurate and repeatable. The aim of this study was to determine the repeatability of relative CBV measurements in newly diagnosed @entity2 multiforme by using several of the most commonly published estimation techniques. MATERIALS AND METHODS: The relative CBV estimates were calculated from dynamic susceptibility contrast MR imaging in double-baseline examinations for 33 @entity0 with treatment-na  ve and pathologically proved @entity2 multiforme ( @entity0 = 20; mean age = 55 years). Normalized and standardized relative CBV were calculated by using 6 common postprocessing methods. The repeatability of both normalized and standardized relative CBV, in both @entity1 and contralateral brain, was examined for each method with metrics of repeatability, including the repeatability coefficient and within-subject coefficient of variation. The minimum sample size required to detect a parameter change of 10% or 20% was also determined for both normalized relative CBV and standardized relative CBV for each estimation method. RESULTS: When ordered by the repeatability coefficient, methods using postprocessing leakage correction and   R2*(t) techniques offered superior repeatability. Across processing techniques, the standardized relative CBV repeatability in normal-appearing brain was comparable with that in @entity1 (P = .31), yet inferior in @entity1 for normalized relative CBV (P = .03). On the basis of the within-subject coefficient of variation, @entity1 standardized relative CBV estimates were less variable (13%-20%) than normalized relative CBV estimates (24%-67%). The minimum number of @entity0 needed to detect a change of 10% or 20% is 118-643 or 30-161 for normalized relative CBV and 109-215 or 28-54 for standardized relative CBV. CONCLUSIONS: The   R2* estimation methods that incorporate leakage correction offer the best repeatability for relative CBV, with standardized relative CBV being less variable and requiring fewer @entity0 to detect a change compared with normalized relative CBV.

title: Repeatability of Standardized and Normalized Relative CBV in @entity0 with Newly Diagnosed XXXX .

answer: @entity2


abstract: BACKGROUND AND PURPOSE: For more widespread clinical use advanced imaging methods such as relative cerebral blood volume must be both accurate and repeatable. The aim of this study was to determine the repeatability of relative CBV measurements in newly diagnosed @entity2 multiforme by using several of the most commonly published estimation techniques. MATERIALS AND METHODS: The relative CBV estimates were calculated from dynamic susceptibility contrast MR imaging in double-baseline examinations for 33 @entity0 with treatment-na  ve and pathologically proved @entity2 multiforme ( @entity0 = 20; mean age = 55 years). Normalized and standardized relative CBV were calculated by using 6 common postprocessing methods. The repeatability of both normalized and standardized relative CBV, in both @entity1 and contralateral brain, was examined for each method with metrics of repeatability, including the repeatability coefficient and within-subject coefficient of variation. The minimum sample size required to detect a parameter change of 10% or 20% was also determined for both normalized relative CBV and standardized relative CBV for each estimation method. RESULTS: When ordered by the repeatability coefficient, methods using postprocessing leakage correction and   R2*(t) techniques offered superior repeatability. Across processing techniques, the standardized relative CBV repeatability in normal-appearing brain was comparable with that in @entity1 (P = .31), yet inferior in @entity1 for normalized relative CBV (P = .03). On the basis of the within-subject coefficient of variation, @entity1 standardized relative CBV estimates were less variable (13%-20%) than normalized relative CBV estimates (24%-67%). The minimum number of @entity0 needed to detect a change of 10% or 20% is 118-643 or 30-161 for normalized relative CBV and 109-215 or 28-54 for standardized relative CBV. CONCLUSIONS: The   R2* estimation methods that incorporate leakage correction offer the best repeatability for relative CBV, with standardized relative CBV being less variable and requiring fewer @entity0 to detect a change compared with normalized relative CBV.

title: Repeatability of Standardized and Normalized Relative CBV in XXXX with Newly Diagnosed @entity2 .

answer: @entity0


abstract: UNASSIGNED: Endoplasmic reticulum (ER) stress is associated with various @entity1 . However, its pathophysiological relevance and the underlying mechanisms in the context of @entity5 /reoxygenation (H/R) in endothelial cells are not fully understood. Previous findings have suggested that @entity6 ( @entity9 ), the major @entity2 , protected against @entity3 by activating @entity12 -activated protein kinase (AMPK). This study investigated the role of ER stress in endothelial cells during H/R and explored the beneficial effects of @entity9 . Our results showed that H/R triggered ER stress and apoptosis in endothelial cells, evidenced by the elevation of @entity4 -regulated protein 78, cleaved caspase-12 and C/EBP homologous protein expression. @entity9 significantly decreased ER stress and @entity13 mediated @entity8 - @entity7 nick end labeling positive cells and restored ER ultrastructural changes induced by H/R, possibly via protein kinase-like ER kinase and @entity11 -requiring kinase 1 pathways. Additionally, @entity10 , a type-3 muscarinic @entity9 receptor (M3 AChR) inhibitor, abolished @entity9 -mediated increase in AMPK phosphorylation during H/R. Furthermore, M3 AChR or AMPK siRNA abrogated the @entity9 -elicited the attenuation of ER stress in endothelial cells, indicating that the salutary effects of @entity9 were likely mediated by M3 AChR-AMPK signaling. Overall, @entity9 activated AMPK through M3 AChR, thereby inhibited H/R-induced ER stress and apoptosis in endothelial cells. We have suggested for the first time that AMPK may function as an essential intermediate step between M3 AChR stimulation and inhibition of ER stress-associated apoptotic pathway during H/R, which may help to develop novel therapeutic approaches targeting ER stress to prevent or alleviate @entity0 /reperfusion injury.

title: @entity6 ameliorates endoplasmic reticulum stress in endothelial cells after XXXX /reoxygenation via M3 AChR-AMPK signaling.

answer: @entity5


abstract: UNASSIGNED: Endoplasmic reticulum (ER) stress is associated with various @entity1 . However, its pathophysiological relevance and the underlying mechanisms in the context of @entity5 /reoxygenation (H/R) in endothelial cells are not fully understood. Previous findings have suggested that @entity6 ( @entity9 ), the major @entity2 , protected against @entity3 by activating @entity12 -activated protein kinase (AMPK). This study investigated the role of ER stress in endothelial cells during H/R and explored the beneficial effects of @entity9 . Our results showed that H/R triggered ER stress and apoptosis in endothelial cells, evidenced by the elevation of @entity4 -regulated protein 78, cleaved caspase-12 and C/EBP homologous protein expression. @entity9 significantly decreased ER stress and @entity13 mediated @entity8 - @entity7 nick end labeling positive cells and restored ER ultrastructural changes induced by H/R, possibly via protein kinase-like ER kinase and @entity11 -requiring kinase 1 pathways. Additionally, @entity10 , a type-3 muscarinic @entity9 receptor (M3 AChR) inhibitor, abolished @entity9 -mediated increase in AMPK phosphorylation during H/R. Furthermore, M3 AChR or AMPK siRNA abrogated the @entity9 -elicited the attenuation of ER stress in endothelial cells, indicating that the salutary effects of @entity9 were likely mediated by M3 AChR-AMPK signaling. Overall, @entity9 activated AMPK through M3 AChR, thereby inhibited H/R-induced ER stress and apoptosis in endothelial cells. We have suggested for the first time that AMPK may function as an essential intermediate step between M3 AChR stimulation and inhibition of ER stress-associated apoptotic pathway during H/R, which may help to develop novel therapeutic approaches targeting ER stress to prevent or alleviate @entity0 /reperfusion injury.

title: XXXX ameliorates endoplasmic reticulum stress in endothelial cells after @entity5 /reoxygenation via M3 AChR-AMPK signaling.

answer: @entity6


abstract: @entity4 of the ovary are rather frequent @entity1 of the ovary. They take one fourth of all benign neoplasms of the ovary and 50-70% of @entity2 . The @entity3 incidence is in the fifth decade. The @entity1 is bilateral in 12-20% of cases, more frequently in elder @entity0 . The @entity1 appears in cystic, papillary, adenofibromatous and mixed forms. @entity1 are usually unilocular but may be multilocular. The size of the mass varies up to 30 cm, average size is 10 cm. We report on a 62 year old @entity0 in whom a gigantic @entity4 of the ovary, 29 kg of weight, 55 x 35 x 35 cm. in diameter, was removed. The recovery was uneventful and the @entity0 stayed symptom-free. To our best knowledge this was the largest @entity1 of this kind ever reported.

title: [Giant XXXX of the ovary].

answer: @entity4


abstract: BACKGROUND: @entity1 ( @entity1 ) are a major cause of adult morbidity worldwide. In 1991, the World Health Organization (WHO) introduced the concept of the "syndromic approach" to managing @entity1 in low-income countries, however, there has been some controversy regarding the ongoing use of this approach. OBJECTIVES: (1) To understand the use of the syndromic approach to managing @entity1 in low-income countries, and to determine if evidence supports its continued use. (2) To help Canadian doctors understand the past STD management of immigrant @entity0 from low-income countries, and evaluate the direct effect (if any) of such medical practices to the @entity0 's health and perception of health in Canada. METHODS: Medline was searched under the key words " @entity1 ," "developing nations," and "syndrome," as well as "algorithms," "prevention and control," and "WHO." Research articles and data were also accessed from the Web sites of WHO, UNAIDS, Reproductive Health Online (JHSPH), and the Centers for Disease Control and Prevention (USA). Data were selected based on the relevance to the topic, and research articles assessed from a methodological perspective. Most research articles were of Level II-2 evidence or lower as described using the Evaluation of Evidence criteria outlined in the Report of the Canadian Task Force on the Periodic Health Exam. RESULTS: In resource-poor countries, the use of the syndromic approach is appropriate for high-risk groups and for symptomatic individuals. However, it is still a poor screening approach when applied to asymptomatic cases, particularly in @entity0 . Risk scoring and simple laboratory tests help to increase the algorithmic sensitivity of the syndromic approach. CONCLUSION: Syndromic management involves making clinical decisions based on a @entity0 's symptoms and signs. Until inexpensive, simple, and accurate STD diagnostics are developed and made available for use in low-income countries, a modified syndromic approach is the most feasible method of STD management in these countries. It is useful for Canadian physicians to be aware of this approach especially when caring for @entity0 from these countries.

title: The syndromic approach to treatment of XXXX in low-income countries: issues, challenges, and future directions.

answer: @entity1


abstract: Long-term growth retardation occurs in @entity0 and @entity4 occur among @entity0 and adults who have been burned or suffer other injuries that result in a systemic inflammatory response. The purpose of this study was to define some of the growth, and to determine cancellous and cortical bone changes that occur following @entity2 in several contrasting strains of @entity1 . Male C3H/HeN and Balb/c @entity1 were given about a 20% total @entity2 and 10 days later skeletal tissues were collected. The bone ash weights of the burned animals from both strains were less than their sham controls. In both strains, cancellous bone volumes were less in the burned animals than in their respective sham or baseline control groups. The loss of bone was particularly evident in the secondary spongiosa regions and also included a decrease in trabecular thickness and connectivity and an increase in trabecular separation. @entity3 was suppressed in the burn animals. In the burned animals, indices of cancellous bone formation were substantially reduced whereas those in cortical bone were essentially nonexistent. The numbers of osteoclasts were increased in cancellous bone, and endocortical eroded surface was increased in the burn animals. These data show that there are rapid and profound changes in skeletal growth and metabolism in an experimental model of @entity2 . In general, a greater relative response was observed in the Balb/c vs. the C3H/HeN strain. @entity2 resulted in a rapid and dramatic suppression of bone formation and endochondral growth with increased bone resorption in both cancellous and cortical bone.

title: Effects of thermal injury on skeletal metabolism in two strains of XXXX .

answer: @entity1


abstract: BACKGROUND: A newly-designed gastrojejunostomy with duodenal partition was hypothesized to be a relatively easier and safer gastric bypass procedure in interrupting the "food reentry", as compared with antrectomy, for @entity0 with unresectable @entity1 . METHODS: Thirty @entity0 with unresectable periampullary malignancy were randomized to receive gastrojejunostomy with either duodenal partition or antrectomy, in addition to biliary bypass, to compare surgical risk and efficacy of the gastric bypass between these two groups. RESULTS: Gastrojejunotomy with either duodenal partition or antrectomy could significantly shorten the gastric emptying time 6 weeks after operation. There was no significant difference between these two groups in @entity3 ( @entity3 ) symptoms, gastric emptying time, and time for resuming oral diet intake after operation. The median operation time was shorter in the duodenal partition group (180 min) than in the antrectomy group (240 min), p < 0.01. The median @entity2 was less in the duodenal partition group (250 ml) than in the antrectomy group (400 ml), (p = 0.01). Complications occurred in 3 (20%) @entity0 with duodenal partition and in 7 (47%) @entity0 with antrectomy, (p = 0.25). One duodenal stump leakage occurred in antrectomy group. Surgical mortality occurred in 2 @entity0 with antrectomy. CONCLUSIONS: Duodenal partition, with shorter operation time and less @entity2 , had similar efficacy with antrectomy in correction of @entity3 . Therefore, duodenal partition could be a relatively easier and safer alternative to antrectomy in interrupting the "food reentry" in gastrojejunostomy for @entity0 with unresectable @entity1 .

title: Randomized trial of gastrojejunostomy with duodenal partition versus antrectomy in unresectable XXXX .

answer: @entity1


abstract: BACKGROUND: The prevalence of @entity1 is increasing in the United States. @entity4 is common as @entity1 progresses. However, an accepted method to screen these @entity0 for @entity4 is lacking. The 6-question undernutrition screening tool was developed for professionals without nutrition training to identify a decline in the nutrition status of @entity0 with @entity2 . A 3-phase validation study was completed to assess face, content, and clinical validity of the screening tool in ambulatory @entity0 with @entity2 . METHODS: In phase I, face validity was determined by surveying 13 @entity1 professionals. In phase II, content validity was assessed by surveying 12 registered dietitians who specialize in @entity1 . In phase III, a cross-sectional investigation was completed to compare the agreement between the undernutrition screening tool and nutrition assessment by a registered dietitian (RD). RESULTS: Twenty-two @entity0 with a diagnosis of @entity2 participated in phase III of the investigation. The RD assessment identified undernutrition in 82% of @entity0 (95% CI, 60%-95%). The k statistic indicated a fair agreement between the screening tool and RD assessment. Sensitivity and specificity of the tool were 72% and 75%, respectively, and positive predictive value was 93%. CONCLUSIONS: Feedback from phase I, II, and III indicate that the undernutrition screening tool is simple, is easy to use, and measures the constructs that have the strongest link with @entity1 . Additional minor adjustments to the screening tool and a multicenter investigation are indicated to confirm clinical effectiveness and @entity3 of the tool.

title: Validation of a Screening Tool to Identify Undernutrition in Ambulatory @entity0 With XXXX .

answer: @entity2


abstract: BACKGROUND: The prevalence of @entity1 is increasing in the United States. @entity4 is common as @entity1 progresses. However, an accepted method to screen these @entity0 for @entity4 is lacking. The 6-question undernutrition screening tool was developed for professionals without nutrition training to identify a decline in the nutrition status of @entity0 with @entity2 . A 3-phase validation study was completed to assess face, content, and clinical validity of the screening tool in ambulatory @entity0 with @entity2 . METHODS: In phase I, face validity was determined by surveying 13 @entity1 professionals. In phase II, content validity was assessed by surveying 12 registered dietitians who specialize in @entity1 . In phase III, a cross-sectional investigation was completed to compare the agreement between the undernutrition screening tool and nutrition assessment by a registered dietitian (RD). RESULTS: Twenty-two @entity0 with a diagnosis of @entity2 participated in phase III of the investigation. The RD assessment identified undernutrition in 82% of @entity0 (95% CI, 60%-95%). The k statistic indicated a fair agreement between the screening tool and RD assessment. Sensitivity and specificity of the tool were 72% and 75%, respectively, and positive predictive value was 93%. CONCLUSIONS: Feedback from phase I, II, and III indicate that the undernutrition screening tool is simple, is easy to use, and measures the constructs that have the strongest link with @entity1 . Additional minor adjustments to the screening tool and a multicenter investigation are indicated to confirm clinical effectiveness and @entity3 of the tool.

title: Validation of a Screening Tool to Identify Undernutrition in Ambulatory XXXX With @entity2 .

answer: @entity0


abstract: @entity1 state and an increased incidence of @entity4 are reported in @entity2 . The @entity1 state is related to an increase in plasma clotting factors, especially Factor VIII and @entity6 factor complex, and to an impairment of fibrinolytic capacity. Retrospective analysis of postoperative @entity4 in a large group of @entity0 with @entity2 , including 75 @entity0 (group 1) evaluated in the period from 1972-1981 not receiving anticoagulants, and 232 @entity0 (group 2), evaluated in the period from 1982-2000. @entity0 of group 1 underwent routine hemostatic function, i.e. prothrombin time and activated partial thromboplastine time. @entity0 of group 2 underwent a thorough investigation as to hemostatic parameters and received prophylactic treatment with heparin and/or @entity5 . @entity0 with @entity2 showed @entity7 . A significant correlation between activated partial thromboplastine time and urinary free @entity3 was observed. During follow-up, 15 @entity0 (20%; mean follow-up, 9.4 +/- 6.4 yr) of group 1 and 14 (6.0%; mean follow-up, 6.6 +/- 4.2 yr) of group 2 showed @entity4 . Of these @entity0 , eight of group 1 and one of group 2 died. Survival analysis demonstrated a significantly higher morbidity and mortality due to @entity4 in group 1, not receiving anticoagulant prevention, than in group 2, treated with anticoagulants in the perioperative period until cure of the disease and normalization of clotting parameters. @entity2 is associated with a @entity1 state. An adequate anticoagulant prophylaxis can reverse this prothrombotic state and avoid postoperative @entity4 .

title: Anticoagulant prophylaxis markedly reduces XXXX in @entity2 .

answer: @entity4


abstract: @entity1 state and an increased incidence of @entity4 are reported in @entity2 . The @entity1 state is related to an increase in plasma clotting factors, especially Factor VIII and @entity6 factor complex, and to an impairment of fibrinolytic capacity. Retrospective analysis of postoperative @entity4 in a large group of @entity0 with @entity2 , including 75 @entity0 (group 1) evaluated in the period from 1972-1981 not receiving anticoagulants, and 232 @entity0 (group 2), evaluated in the period from 1982-2000. @entity0 of group 1 underwent routine hemostatic function, i.e. prothrombin time and activated partial thromboplastine time. @entity0 of group 2 underwent a thorough investigation as to hemostatic parameters and received prophylactic treatment with heparin and/or @entity5 . @entity0 with @entity2 showed @entity7 . A significant correlation between activated partial thromboplastine time and urinary free @entity3 was observed. During follow-up, 15 @entity0 (20%; mean follow-up, 9.4 +/- 6.4 yr) of group 1 and 14 (6.0%; mean follow-up, 6.6 +/- 4.2 yr) of group 2 showed @entity4 . Of these @entity0 , eight of group 1 and one of group 2 died. Survival analysis demonstrated a significantly higher morbidity and mortality due to @entity4 in group 1, not receiving anticoagulant prevention, than in group 2, treated with anticoagulants in the perioperative period until cure of the disease and normalization of clotting parameters. @entity2 is associated with a @entity1 state. An adequate anticoagulant prophylaxis can reverse this prothrombotic state and avoid postoperative @entity4 .

title: Anticoagulant prophylaxis markedly reduces @entity4 in XXXX .

answer: @entity2


abstract: BACKGROUND _ AIMS: Long noncoding RNA Hotair has been considered as a pro-oncogene in multiple @entity1 . Although there is a group of emerging evidence which reveals its biological function and the association with clinical prognosis, the precise mechanism remains largely elusive. METHODS: We investigated the function and mechanism of Hotair in @entity3 ( @entity3 ) cell models and a xenograft @entity2 model. The regulatory network between miR-218 and Hotair was elucidated by RNA immunoprecipitation and luciferase reporter assays. Finally, the corrections between Hotair, miR-218 and the target gene @entity5 were evaluated in 52 paired @entity3 specimens. RESULTS: In this study, we reported that Hotair negatively regulated miR-218 expression in @entity3 , which might be mediated through an EZH2-targeting-miR-218-2 promoter regulatory axis. Further investigation revealed that Hotair knockdown dramatically inhibited cell viability and induced G1-phase arrest in vitro and suppressed tumorigenicity in vivo by promoting miR-218 expression. Oncogene @entity5 was demonstrated to be a functional target of miR-218 and the main downstream targets @entity4 ( @entity4 ) and @entity4 (ARF) signaling were activated in Hotair-suppressed tumorigenesis. In primary @entity0 @entity3 specimens, Hotair and @entity5 were concordantly upregulated whereas miR-218 was downregulated in these tissues. Furthermore, Hotair was inversely associated with miR-218 expression and positively correlated with @entity5 expression in these clinical tissues. CONCLUSION: Hotair silence activates @entity4 ( @entity4 ) and @entity4 (ARF) signaling by enhancing miR-218 expression and suppressing @entity5 expression, resulting in the suppression of tumorigenesis in @entity3 .

title: Hotair Mediates Hepatocarcinogenesis through Suppressing MiRNA-218 Expression and Activating XXXX and @entity4 Signaling.

answer: @entity4


abstract: BACKGROUND _ AIMS: Long noncoding RNA Hotair has been considered as a pro-oncogene in multiple @entity1 . Although there is a group of emerging evidence which reveals its biological function and the association with clinical prognosis, the precise mechanism remains largely elusive. METHODS: We investigated the function and mechanism of Hotair in @entity3 ( @entity3 ) cell models and a xenograft @entity2 model. The regulatory network between miR-218 and Hotair was elucidated by RNA immunoprecipitation and luciferase reporter assays. Finally, the corrections between Hotair, miR-218 and the target gene @entity5 were evaluated in 52 paired @entity3 specimens. RESULTS: In this study, we reported that Hotair negatively regulated miR-218 expression in @entity3 , which might be mediated through an EZH2-targeting-miR-218-2 promoter regulatory axis. Further investigation revealed that Hotair knockdown dramatically inhibited cell viability and induced G1-phase arrest in vitro and suppressed tumorigenicity in vivo by promoting miR-218 expression. Oncogene @entity5 was demonstrated to be a functional target of miR-218 and the main downstream targets @entity4 ( @entity4 ) and @entity4 (ARF) signaling were activated in Hotair-suppressed tumorigenesis. In primary @entity0 @entity3 specimens, Hotair and @entity5 were concordantly upregulated whereas miR-218 was downregulated in these tissues. Furthermore, Hotair was inversely associated with miR-218 expression and positively correlated with @entity5 expression in these clinical tissues. CONCLUSION: Hotair silence activates @entity4 ( @entity4 ) and @entity4 (ARF) signaling by enhancing miR-218 expression and suppressing @entity5 expression, resulting in the suppression of tumorigenesis in @entity3 .

title: Hotair Mediates Hepatocarcinogenesis through Suppressing MiRNA-218 Expression and Activating @entity4 and XXXX Signaling.

answer: @entity4


abstract: OBJECTIVES/HYPOTHESIS: It has been hypothesized that etiology of @entity1 may serve as an independent variable in performance after cochlear implantation. To test this hypothesis, the authors identified pediatric cochlear implant recipients with @entity3 ( @entity3 )-related @entity2 . The study examines performance outcomes associated with @entity3 @entity2 -causing allele variants. STUDY DESIGN: Pediatric cochlear implant @entity0 were screened for @entity3 allele variants; statistical comparisons were made with prospectively obtained performance measures. METHODS: From 181 @entity0 who participated in a nationwide cochlear implant research program, 122 @entity0 were identified with @entity4 and invited to participate. Screening for @entity3 allele variants was completed for 55 @entity0 . The @entity0 were homogeneous with respect to age (8 or 9 y) and age at implant (before age 5 y). All @entity0 have previously undergone a prospective regimented battery of performance measures. RESULTS: Performance measures were compared between 22 @entity0 with and 33 @entity0 without mutations to determine whether @entity3 status was a significant predictor of cochlear implant outcomes. Reading and cognitive outcomes were significantly dependent on connexin status. The group of @entity0 who tested positive for @entity3 -related @entity2 scored significantly higher on a nonverbal cognitive measure, Block Design, and on a measure of reading comprehension. CONCLUSION: The isolated insult to the cochlea created by @entity3 allele variants allows for preservation of central cognitive function. Better reading performance is seen in @entity0 with @entity3 -related @entity2 .

title: The effect of XXXX allele variants on performance after cochlear implantation.

answer: @entity3


abstract: @entity2 ( @entity2 ) and related diseases are a heterogeneous group of disorders characterized by impaired telomere maintenance, known collectively as the telomeropathies. Disease-causing variants have been identified in 10 telomere-related genes including the reverse transcriptase ( @entity1 ) and the RNA component ( @entity3 ) of the telomerase complex. Variants in @entity3 and @entity1 can impede telomere elongation causing stem cells to enter premature replicative senescence and/or apoptosis as telomeres become critically short. This explains the major impact of the disease on highly proliferative tissues such as the bone marrow and skin. However, telomerase variants are not always fully penetrant and in some families disease-causing variants are seen in asymptomatic family members. As a result, determining the pathogenic status of newly identified variants in @entity3 or @entity1 can be quite challenging. Over a 3-year period, we have identified 26 telomerase variants (16 of which are novel) in 23 families. Additional investigations (including family segregation and functional studies) enabled these to be categorized into 3 groups: (1) disease-causing (n = 15), (2) uncertain status (n = 6), and (3) bystanders (n = 5). Remarkably, this process has also enabled us to identify families with novel mechanisms of inheriting @entity0 telomeropathies. These include triallelic mutations, involving 2 different telomerase genes, and an epigenetic-like inheritance of short telomeres in the absence of a telomerase mutation. This study therefore highlights that telomerase variants have highly variable functional and clinical manifestations and require thorough investigation to assess their pathogenic contribution.

title: Triallelic and epigenetic-like inheritance in XXXX disorders of telomerase.

answer: @entity0