abstract: AIM: To evaluate and compare the long-term outcome of sacrospinous ligament fixation (SSF) in combination with various other compartment defect native tissue repairs with hysterectomy or hysteropexy. METHODS: Medical records of 159 @entity0 who underwent surgery for @entity1 ( @entity1 ) between April 2004 and August 2008 were reviewed retrospectively. @entity0 were assessed at baseline and at 5-year postoperative follow-up. SSF, anterior (AC) and posterior colporrhaphy (PC), both with and without hysterectomy, were performed. Primary outcome was objective cure ( @entity1 quantification system [ @entity1 -Q]  <=1) and subjective cure (negative response to questions 2 and 3 on Pelvic Organ Prolapse Distress Inventory 6 [POPDI-6]). Subanalysis was done on @entity0 who had uterus preserved compared with those with vaginal hysterectomy. RESULTS: Postoperative data were available for 146 @entity0 : 120 in the hysterectomy group and 26 in the hysteropexy group. Mean age, parity, postmenopausal status and mean operating time in the hysterectomy group were significantly higher than in the hysteropexy group. At median follow-up of 86 months, objective cure at overall compartments for all @entity0 was 67.8%, and for subjective cure, this was 64.4%. There was no difference in the adjusted odds ratio for objective and subjective cure rates in both groups, but the hysterectomy group had a significantly lower mean total POPDI-6 score. CONCLUSION: SSF plus AC and PC have a low reoperation rate despite a moderate success rate at 7-year follow-up. There was no difference in the adjusted objective, subjective success rates and sexual function between sacrospinous hysteropexy and hysterectomy. The hysterectomy group, however, had fewer bothersome prolapse symptoms.

title: Long-term outcome of native tissue reconstructive vaginal surgery for advanced XXXX at 86 months: Hysterectomy versus hysteropexy.

answer: @entity1


abstract: BACKGROUND: Several North American studies have observed survival benefit in @entity0 exposed to b-blockers following @entity2 ( @entity2 ). The purpose of this study was to evaluate the effect of b-blockade on mortality in a Swedish cohort of isolated severe @entity2 @entity0 . METHODS: The @entity1 registry of an urban academic @entity1 center was queried to identify @entity0 with an isolated severe @entity2 between 1/2007 and 12/2011. Isolated severe @entity2 was defined as an @entity3 with an Abbreviated Injury Scale (AIS) >= 3 excluding extra-cranial injuries AIS >= 3. Multivariable logistic regression analysis was used to determine the effect of b-blocker exposure on mortality. Also, a subgroup analysis was performed to investigate the risk of mortality in @entity0 on pre-admission b-blocker versus not and the effect of specific type of b-blocker on the overall outcome. RESULTS: Overall, 874 @entity0 met the study criteria. Of these, 33  % (n  =  287) were exposed to b-blockers during their hospital admission. The exposed @entity0 were older (62      16  years vs. 49      21  years, p  <  0.001), and more severely injured based on their admission GCS, ISS, and head AIS scores (GCS  <=8: 32  % vs. 28  %, p  =  0.007; ISS >= 16: 71  % vs. 59  %, p  =  0.001; head AIS >= 4: 60  % vs. 45  %, p  <  0.001). The crude mortality was higher in @entity0 who did not receive b-blockers (17  % vs. 11  %, p  =  0.007) during their admission. After adjustment for significant confounders, the @entity0 not exposed to b-blockers had a 5-fold increased risk of in-hospital mortality (AOR 5.0, CI 95  % 2.7-8.5, p  =  0.001). No difference in survival was noted in regards to the type of b-blocker used. Subgroup analysis revealed a higher risk of mortality in @entity0 naive to b-blockers compared to those on pre-admission b-blocker therapy (AOR 3.0 CI 95  % 1.2-7.1, p  =  0.015). CONCLUSIONS: b-blocker exposure after isolated severe @entity2 is associated with significantly improved survival. We also noted decreased mortality in @entity0 on pre-admission b-blocker therapy compared to @entity0 naive to such treatment. Further prospective studies are warranted.

title: The Effect of b-blockade on Survival After Isolated Severe XXXX .

answer: @entity2


abstract: MAIN CONCLUSION: During re-establishment of desiccation tolerance (DT), early events promote initial protection and @entity0 , while late events promote stress adaptation and contribute to survival in the dry state. Mature seeds of @entity1 are desiccation tolerant, but they lose desiccation tolerance (DT) while progressing to germination. Yet, there is a small developmental window during which DT can be rescued by treatment with @entity3 ( @entity4 ). To gain temporal resolution and identify relevant genes in this process, data from a time series of microarrays were used to build a gene co-expression network. The network has two regions, namely early response (ER) and late response (LR). Genes in the ER region are related to biological processes, such as dormancy, acquisition of DT and drought, amplification of signals, @entity0 and induction of protection mechanisms (such as LEA proteins). Genes in the LR region lead to inhibition of photosynthesis and primary metabolism, promote adaptation to stress conditions and contribute to seed longevity. Phenotyping of 12 hubs in relation to re-establishment of DT with T-DNA insertion lines indicated a significant increase in the ability to re-establish DT compared with the wild-type in the lines cbsx4, at3g53040 and at4g25580, suggesting the operation of redundant and compensatory mechanisms. Moreover, we show that re-establishment of DT by @entity2 and @entity4 occurs through partially overlapping mechanisms. Our data confirm that co-expression network analysis is a valid approach to examine data from time series of transcriptome analysis, as it provides promising insights into biologically relevant relations that help to generate new information about the roles of certain genes for DT.

title: A gene co-expression network predicts functional genes controlling the re-establishment of desiccation tolerance in germinated XXXX seeds.

answer: @entity1


abstract: UNASSIGNED: Individuals with @entity2 display @entity1 for which available treatments offer only limited benefits. Yet, findings from studies of animals, clinical and nonclinical populations have linked neurocognitive improvements to increases in @entity3 ( @entity3 ) via aerobic exercise training (AE). Such improvements have been attributed to up-regulation of @entity4 ( @entity4 ). However, the impact of AE on neurocognition, and the putative role of @entity4 , have not been investigated in @entity2 . Employing a proof-of-concept, single-blind, randomized clinical trial design, 33 individuals with @entity2 were randomized to receive standard psychiatric treatment (n = 17; "treatment as usual"; TAU) or attend a 12-week AE program (n = 16) utilizing active-play video games (Xbox 360 Kinect) and traditional AE equipment. @entity0 completed assessments of @entity3 (indexed by VO2 peak ml/kg/min), neurocognition (MATRICS Consensus Cognitive Battery), and serum- @entity4 before and after and 12-week period. Twenty-six @entity0 (79%) completed the study. At follow-up, the AE @entity0 improved their @entity3 by 18.0% vs a -0.5% decline in the TAU group (P = .002) and improved their neurocognition by 15.1% vs -2.0% decline in the TAU group (P = .031). Hierarchical multiple regression analyses indicated that enhancement in @entity3 and increases in @entity4 predicted 25.4% and 14.6% of the neurocognitive improvement variance, respectively. The results indicate AE is effective in enhancing neurocognitive functioning in @entity0 with @entity2 and provide preliminary support for the impact of AE-related @entity4 up-regulation on neurocognition in this population. Poor @entity3 represents a modifiable risk factor for @entity1 in @entity2 for which AE training offer a safe, nonstigmatizing, and side-effect-free intervention.

title: The Impact of Aerobic Exercise on @entity4 and Neurocognition in Individuals With XXXX : A Single-Blind, Randomized Clinical Trial.

answer: @entity2


abstract: UNASSIGNED: Individuals with @entity2 display @entity1 for which available treatments offer only limited benefits. Yet, findings from studies of animals, clinical and nonclinical populations have linked neurocognitive improvements to increases in @entity3 ( @entity3 ) via aerobic exercise training (AE). Such improvements have been attributed to up-regulation of @entity4 ( @entity4 ). However, the impact of AE on neurocognition, and the putative role of @entity4 , have not been investigated in @entity2 . Employing a proof-of-concept, single-blind, randomized clinical trial design, 33 individuals with @entity2 were randomized to receive standard psychiatric treatment (n = 17; "treatment as usual"; TAU) or attend a 12-week AE program (n = 16) utilizing active-play video games (Xbox 360 Kinect) and traditional AE equipment. @entity0 completed assessments of @entity3 (indexed by VO2 peak ml/kg/min), neurocognition (MATRICS Consensus Cognitive Battery), and serum- @entity4 before and after and 12-week period. Twenty-six @entity0 (79%) completed the study. At follow-up, the AE @entity0 improved their @entity3 by 18.0% vs a -0.5% decline in the TAU group (P = .002) and improved their neurocognition by 15.1% vs -2.0% decline in the TAU group (P = .031). Hierarchical multiple regression analyses indicated that enhancement in @entity3 and increases in @entity4 predicted 25.4% and 14.6% of the neurocognitive improvement variance, respectively. The results indicate AE is effective in enhancing neurocognitive functioning in @entity0 with @entity2 and provide preliminary support for the impact of AE-related @entity4 up-regulation on neurocognition in this population. Poor @entity3 represents a modifiable risk factor for @entity1 in @entity2 for which AE training offer a safe, nonstigmatizing, and side-effect-free intervention.

title: The Impact of Aerobic Exercise on XXXX and Neurocognition in Individuals With @entity2 : A Single-Blind, Randomized Clinical Trial.

answer: @entity4


abstract: BACKGROUND: Airway remodeling is a proposed mechanism that underlies the persistent loss of lung function associated with childhood @entity1 . Previous studies have demonstrated that @entity0 lung fibroblasts (HLFs) co-cultured with primary @entity0 bronchial epithelial cells (BECs) from asthmatic @entity0 exhibit greater expression of extracellular matrix (ECM) components compared to co-culture with BECs derived from healthy @entity0 . Myofibroblasts represent a population of differentiated fibroblasts that have greater synthetic activity. We hypothesized co-culture with asthmatic BECs would lead to greater fibroblast to myofibroblast transition (FMT) compared to co-culture with healthy BECs. METHODS: BECs were obtained from well-characterized asthmatic and healthy @entity0 and were proliferated and differentiated at an air-liquid interface (ALI). BEC-ALI cultures were co-cultured with HLFs for 96  hours. RT-PCR was performed in HLFs for @entity2 ( @entity2 ) and flow cytometry was used to assay for @entity2 antibody labeling of HLFs. RT-PCR was also preformed for the expression of tropomyosin-I as an additional marker of myofibroblast phenotype. In separate experiments, we investigated the role of @entity3 in BEC- @entity4 co-cultures using monoclonal antibody inhibition. RESULTS: Expression of @entity2 by HLFs alone was greater than by HLFs co-cultured with healthy BECs, but not different than @entity2 expression by HLFs co-cultured with asthmatic BECs. Flow cytometry also revealed significantly less @entity2 expression by healthy co-co-cultures compared to asthmatic co-cultures or @entity4 alone. Monoclonal antibody inhibition of @entity3 led to similar expression of @entity2 between healthy and asthmatic BEC- @entity4 co-cultures. Expression of topomyosin-I was also significantly increased in @entity4 co-cultured with asthmatic BECs compared to healthy BEC- @entity4 co-cultures or @entity4 cultured alone. CONCLUSION: These findings suggest dysregulation of FMT in @entity4 co-cultured with asthmatic as compared to healthy BECs. Our results suggest @entity3 may be involved in the differential regulation of FMT by asthmatic BECs. These findings further illustrate the importance of BEC- @entity4 cross-talk in asthmatic airway remodeling.

title: Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity3 (CP) is the most commonly used pesticide in agricultural fields worldwide. Exposure to CP and its metabolites creates severe @entity1 in @entity0 beings. Improper handling and uncontrolled application of CP by farmers have lead to the contamination of surface and ground water bodies. Biodegradation offers an efficient and cost effective method for the removal of CP and other toxic @entity2 pesticides from the contaminated environment. The degradation of CP by various microorganisms has been investigated by several researchers over the past few years. This review presents a critical summary of the recent published results on the biodegradation of CP. A diverse range of bacterial species such as Agrobacterium sp., Alcaligenes faecalis, Enterobacter sp. Arthrobacter sp. @entity6 , Pseudomonas sp. etc., fungal species like Trichoderma viridae, @entity4 , Verticillium sp., Acremonium sp. Cladosporium cladosporiodes, etc. and certain algal species viz. @entity5 , Spirulina platensis, Synechocystis sp., etc., have been shown to degrade CP. The efficacy of these communities for CP degradation in batch and continuous modes has also been discussed but more studies are required on continuous reactors. Also, the available published information on kinetics of biodegradation of CP along with the available results on molecular biological approaches are discussed in this work.

title: Utilization of microbial community potential for removal of XXXX : a review.

answer: @entity3


abstract: BACKGROUND: @entity1 are rare benign @entity1 , up to 75% of which occur in the hand, mainly the subungual area. Local recurrence and @entity2 are commonly seen if @entity1 excision is not performed completely or properly. OBJECTIVE: This study was designed to assess the long-term efficacy of microscopic excision of @entity1 . MATERIALS AND METHODS: This retrospective analysis reviewed a total of 22 @entity0 diagnosed with @entity1 who underwent microscopic surgical excision at a single medical center over a 12-year period (2002-2014). Outcomes were analyzed based on symptom relief, recurrence rate, finger function, nail esthetics, and @entity0 satisfaction. RESULTS: With a mean follow-up period of 48.4 months, neither recurrence nor postexcision @entity2 developed in any @entity0 . @entity0 satisfaction was rated as "good" in 86.3% of @entity0 (19/22). CONCLUSION: Microscopic surgical excision enables the surgeon to completely remove a @entity1 while minimizing damage to the nail unit, thereby resulting in significantly decreased recurrence and @entity2 . In this study, an incision made according to the anatomic location provided an easy approach and the best visualization. @entity0 ' finger function was successfully restored, nail esthetic outcome was good, and @entity0 satisfaction was high.

title: Outcome of Microscopic Excision of a XXXX : A 12-Year Evaluation.

answer: @entity1


abstract: Trace elements play an important role in @entity1 metabolism and therefore in the formation of free radicals. Whereas @entity2 and @entity7 are usually the main enhancers of free radical formation, other trace elements, such as @entity3 and @entity12 , protect against the harmful effects of these radicals. To investigate the different protective mechanisms of @entity3 on radical formation, we examined the effects of added @entity3 and @entity7 on @entity4 dismutase activity. We also studied the effects of @entity7 and @entity2 on @entity9 oxidase activity and on the Haber-Weiss cycle ( @entity2 , @entity4 , and @entity5 ), which generates @entity11 radicals in vitro. The @entity10 / @entity9 oxidase radical generating system contained a variety of different physiological ligands for binding the @entity2 . This study confirmed the inhibitory effect of @entity7 on @entity9 oxidase activity. Moreover, it demonstrated that @entity3 inhibited @entity11 radical formation when this formation was catalyzed by a @entity8 - @entity2 complex in the @entity10 / @entity9 oxidase reaction. Finally, @entity0 blood plasma inhibited @entity8 - @entity2 -dependent @entity11 radical formation under the same conditions. Although trace elements seemed responsible for this antioxidant activity of plasma, it is likely that @entity3 played no role as a plasma antioxidant. Indeed, @entity6 appeared to be responsible for most of this effect under our experimental conditions.

title: Effect of XXXX on @entity4 -dependent @entity11 radical production in vitro.

answer: @entity3


abstract: Trace elements play an important role in @entity1 metabolism and therefore in the formation of free radicals. Whereas @entity2 and @entity7 are usually the main enhancers of free radical formation, other trace elements, such as @entity3 and @entity12 , protect against the harmful effects of these radicals. To investigate the different protective mechanisms of @entity3 on radical formation, we examined the effects of added @entity3 and @entity7 on @entity4 dismutase activity. We also studied the effects of @entity7 and @entity2 on @entity9 oxidase activity and on the Haber-Weiss cycle ( @entity2 , @entity4 , and @entity5 ), which generates @entity11 radicals in vitro. The @entity10 / @entity9 oxidase radical generating system contained a variety of different physiological ligands for binding the @entity2 . This study confirmed the inhibitory effect of @entity7 on @entity9 oxidase activity. Moreover, it demonstrated that @entity3 inhibited @entity11 radical formation when this formation was catalyzed by a @entity8 - @entity2 complex in the @entity10 / @entity9 oxidase reaction. Finally, @entity0 blood plasma inhibited @entity8 - @entity2 -dependent @entity11 radical formation under the same conditions. Although trace elements seemed responsible for this antioxidant activity of plasma, it is likely that @entity3 played no role as a plasma antioxidant. Indeed, @entity6 appeared to be responsible for most of this effect under our experimental conditions.

title: Effect of @entity3 on @entity4 -dependent XXXX radical production in vitro.

answer: @entity11


abstract: Trace elements play an important role in @entity1 metabolism and therefore in the formation of free radicals. Whereas @entity2 and @entity7 are usually the main enhancers of free radical formation, other trace elements, such as @entity3 and @entity12 , protect against the harmful effects of these radicals. To investigate the different protective mechanisms of @entity3 on radical formation, we examined the effects of added @entity3 and @entity7 on @entity4 dismutase activity. We also studied the effects of @entity7 and @entity2 on @entity9 oxidase activity and on the Haber-Weiss cycle ( @entity2 , @entity4 , and @entity5 ), which generates @entity11 radicals in vitro. The @entity10 / @entity9 oxidase radical generating system contained a variety of different physiological ligands for binding the @entity2 . This study confirmed the inhibitory effect of @entity7 on @entity9 oxidase activity. Moreover, it demonstrated that @entity3 inhibited @entity11 radical formation when this formation was catalyzed by a @entity8 - @entity2 complex in the @entity10 / @entity9 oxidase reaction. Finally, @entity0 blood plasma inhibited @entity8 - @entity2 -dependent @entity11 radical formation under the same conditions. Although trace elements seemed responsible for this antioxidant activity of plasma, it is likely that @entity3 played no role as a plasma antioxidant. Indeed, @entity6 appeared to be responsible for most of this effect under our experimental conditions.

title: Effect of @entity3 on XXXX -dependent @entity11 radical production in vitro.

answer: @entity4


abstract: OBJECTIVE: To determine predictors of prognostic significance for @entity0 with nonseminomatous @entity1 (NSTC) who have advanced disease at the time of presentation. DESIGN: A chart review with a mean @entity0 follow-up of 5.5 years (range from 0.75 to 13 years). SETTING: University hospitals in Halifax. @entity0 : All @entity0 with NSTC, stages II-B, II-C and III. @entity0 were excluded if the follow-up status at the time the study closed could not be determined. Thirty-three @entity0 were included in the study. Current @entity0 status was determined from the clinical charts and personal communication with the @entity0 or their physicians. INTERVENTIONS: All @entity0 received @entity5 -based chemotherapy. The extent of the disease was assessed by chest radiography or lung tomography, bone scanning, abdominal computed tomography or lymphangiography. MAIN OUTCOME MEASURES: Correlation between levels of beta- @entity0 chorionic gonadotropin (BHCG) and @entity3 ( @entity3 ), comparison of duration of symptoms before initial treatment, response to treatment and survival, and relationship between stage, @entity1 volume and survival. RESULTS: The 3-year overall survival rate was 76%. Seven of 18 @entity0 with symptoms for more than 16 weeks died of disease (p < 0.01). Overall complete response was seen in 27 of 33 @entity0 . All initial nonresponders died. A survival rate of 93% was seen among initial complete responders (p < 0.01). All seven @entity0 with persistent elevation of BHCG levels (p < 0.001) and the two @entity0 with persistent elevation of @entity3 levels (p < 0.01) after the second course of chemotherapy died. CONCLUSIONS: A symptomatic interval of more than 16 weeks, poor response to initial treatment, @entity2 , @entity4 and persistently elevated levels of BHCG and @entity3 were all indicators of poor prognosis.

title: Prognostic factors in metastatic XXXX .

answer: @entity1


abstract: BACKGROUND: Antibiotic-associated @entity1 (AAD) is a common adverse effect of antibiotic (AB) treatment. This study aimed to measure the overall prevalence of AAD (including mild to moderate @entity1 ) in hospitalized AB treated @entity0 , to investigate associated risk factors and to document AAD associated diagnostic investigations, contamination control and treatment. METHODS: During 8 observation days (with time delay of 10-14 days between each observation day), all adult @entity0 hospitalized at an internal medicine ward of 4 Belgian participating hospitals were screened for AB use. @entity0 receiving AB on the observation day were included in the study and screened for signs and symptoms of AAD using a period prevalence methodology. Clinical data were collected for all AB users and AAD related investigations and treatment were collected for the entire duration of AAD. Additionally, nurses noted daily the frequency of all extra care associated to the treatment of the @entity1 . RESULTS: A total of 2543 hospitalized @entity0 were screened of which 743 were treated with AB (29.2%). Included AB users had a mean age of 68 yr (range 16-99) and 52% were male. Penicillins were mostly used (63%) and 19% received more than one AB. AAD was observed in 9.6% of AB users including 4 with confirmed @entity2 infection. AAD started between 1 and 16 days after AB start (median 5) and had a duration of 2 to 41 days (median 4). AAD was significantly associated with higher age and the use of double AB and proton pump inhibitors. AAD @entity0 had extra laboratory investigations (79%), received extra pharmacological treatment (42%) and 10 of them were isolated (14%). AAD related extra nursing time amounted to 51 minutes per day for the treatment of @entity1 . CONCLUSIONS: In this observational study, with one third of hospitalized @entity0 receiving AB, an AAD period prevalence of 9.6% in AB users was found. AAD caused extra investigations and treatment and an estimated extra nursing care of almost one hour per day. Preventive action are highly recommended to reduce the prevalence of AAD and associated health care costs.

title: Prevalence and management of antibiotic associated XXXX in general hospitals.

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) is a common last-resort treatment for @entity2 , but postoperative @entity0 often complain of discrepancies in leg length. This study introduces a device designed to increase the precision of the @entity3 and reduce the incidence of @entity4 . METHODS: Forty-eight @entity0 undergoing @entity2 were divided into two groups, with and without the use of the femoral osteotomy guide. All operations were performed through a posterolateral approach. Differences in leg length were recorded before and after the operation. Measurements were also made to compare the preoperative plan with the actual amount of bone removed. RESULTS: The mean average difference in femoral neck resection height was 0.84  mm when using the osteotomy guide and 1.69  mm without the guide. @entity1 were 5.45  mm and 13.37  mm in the groups with and without the guide, respectively. CONCLUSION: The @entity3 guide is an effectively auxiliary tool for increasing the accuracy of bone resection in arthroplasty using the posterolateral approach. TRIAL REGISTRATION: ChiCTR-OOC-15005904 ; date: 2015-01-30.

title: XXXX guide for total hip arthroplasty.

answer: @entity3


abstract: OBJECTIVE: Our research was conducted to analyze the outcomes of two laparoscopic splenectomy plus pericardial devascularization (LSPD) techniques in the management of portal @entity2 (PTH) and @entity9 . METHODS: Between May 2012 and May 2013, 41 @entity0 with PTH and @entity9 undergoing LSPD were retrospectively analyzed. Of them, 29 @entity0 received LSPD by LigaSure    Vessel Sealing System (LVSS) and Endo-GIA    universal endoscopic vascular linear staplers (Endo-GIA) (EG Group) and 12 @entity0 received LSPD by LVSS and Hem-o-Lock ( @entity7 Group). Operating time, intraoperative @entity3 , postoperative course, and hospitalization costs were compared between the two LSPD combination techniques. RESULTS: There were no significant differences in preoperative @entity0 characteristics of the two groups. Significantly less operating time, intraoperative @entity1 were observed in EG Group. The incidence of @entity5 was lower in the EG Group (3.4 vs. 8.3  %), as well as the incidence of @entity8 (0 vs. 8.3  %). @entity4 was not observed in either group. Uncontrolled bleeding warranted conversion to open surgery in one case in EG Group (conversion rate 3.4  %) and in two cases in @entity7 Group (conversion rate 16.7  %). Two @entity0 (16.7  %) in @entity7 Group underwent successful emergency exploratory laparotomy due to uncontrolled intraabdominal bleeding postoperatively. No re-operation was needed in EG Group. Two @entity0 experienced @entity6 after surgery in each group. Of those, three @entity0 were managed successfully and one @entity0 refused further therapy. While the overall complication rate was significantly lower in EG Group (17.2 vs. 58.3  %, P  <  0.05), overall hospitalization costs remained significantly higher for EG Group. CONCLUSION: The results suggest that the modified Endo-GIA and LVSS technique is a safe and effective combination approach to LSPD with shorter operative time, less intraoperative @entity3 , lower conversion rate to laparotomy, shorter hospital stay, better recovery, and lower postoperative complication rate compared with the Hem-o-Lock and LVSS approach. Higher hospitalization expenses associated with the Endo-GIA and LVSS approach.

title: Comparison of two laparoscopic splenectomy plus pericardial devascularization techniques for management of portal XXXX and @entity9 .

answer: @entity2


abstract: OBJECTIVE: Our research was conducted to analyze the outcomes of two laparoscopic splenectomy plus pericardial devascularization (LSPD) techniques in the management of portal @entity2 (PTH) and @entity9 . METHODS: Between May 2012 and May 2013, 41 @entity0 with PTH and @entity9 undergoing LSPD were retrospectively analyzed. Of them, 29 @entity0 received LSPD by LigaSure    Vessel Sealing System (LVSS) and Endo-GIA    universal endoscopic vascular linear staplers (Endo-GIA) (EG Group) and 12 @entity0 received LSPD by LVSS and Hem-o-Lock ( @entity7 Group). Operating time, intraoperative @entity3 , postoperative course, and hospitalization costs were compared between the two LSPD combination techniques. RESULTS: There were no significant differences in preoperative @entity0 characteristics of the two groups. Significantly less operating time, intraoperative @entity1 were observed in EG Group. The incidence of @entity5 was lower in the EG Group (3.4 vs. 8.3  %), as well as the incidence of @entity8 (0 vs. 8.3  %). @entity4 was not observed in either group. Uncontrolled bleeding warranted conversion to open surgery in one case in EG Group (conversion rate 3.4  %) and in two cases in @entity7 Group (conversion rate 16.7  %). Two @entity0 (16.7  %) in @entity7 Group underwent successful emergency exploratory laparotomy due to uncontrolled intraabdominal bleeding postoperatively. No re-operation was needed in EG Group. Two @entity0 experienced @entity6 after surgery in each group. Of those, three @entity0 were managed successfully and one @entity0 refused further therapy. While the overall complication rate was significantly lower in EG Group (17.2 vs. 58.3  %, P  <  0.05), overall hospitalization costs remained significantly higher for EG Group. CONCLUSION: The results suggest that the modified Endo-GIA and LVSS technique is a safe and effective combination approach to LSPD with shorter operative time, less intraoperative @entity3 , lower conversion rate to laparotomy, shorter hospital stay, better recovery, and lower postoperative complication rate compared with the Hem-o-Lock and LVSS approach. Higher hospitalization expenses associated with the Endo-GIA and LVSS approach.

title: Comparison of two laparoscopic splenectomy plus pericardial devascularization techniques for management of portal @entity2 and XXXX .

answer: @entity9


abstract: Transesophageal overdrive atrial pacing is effective and safe for @entity4 . The influence of antiarrhythmic drug therapy on this procedure is controversial. In this study, we investigated whether oral @entity5 may facilitate this procedure. Thirty @entity0 with @entity4 were randomized into 2 groups in which transesophageal pacing was attempted: group A, without treatment; and group B, after oral administration of @entity5 600 mg. Transesophageal pacing was effective in interrupting @entity4 in 53% of @entity0 (8 of 15) in group A and in 87% of @entity0 (13 of 15) in group B. A significant lengthening of the flutter cycle was observed with respect to the baseline in @entity0 given @entity5 (261 +/- 23 vs 217 +/- 25, p < 0.01). Sinus rhythm resumed at a shorter paced cycle in group A @entity0 (166 +/- 13 vs 187 +/- 14 ms, p < 0.01). The transesophageal threshold for stable atrial capture was significantly lower in group A (20.5 +/- 0.2 vs 23.3 +/- 1.2, p < 0.01). In no @entity0 was the threshold for atrial capture higher than the @entity1 threshold. We did not observe abrupt enhancement of @entity2 . We conclude that @entity5 is effective and safe when used with transesophageal pacing in the termination of @entity4 . The slowing effect of the drug on intraatrial conduction and the possible stabilizing effect on the reentry circuit appear to be outweighed by the positive effect of @entity5 on the excitable gap of the circuit, facilitating its capture and accounting for the beneficial effect of the drug on @entity3 termination.

title: XXXX termination by overdrive transesophageal pacing and the facilitating effect of oral @entity5 .

answer: @entity4


abstract: Transesophageal overdrive atrial pacing is effective and safe for @entity4 . The influence of antiarrhythmic drug therapy on this procedure is controversial. In this study, we investigated whether oral @entity5 may facilitate this procedure. Thirty @entity0 with @entity4 were randomized into 2 groups in which transesophageal pacing was attempted: group A, without treatment; and group B, after oral administration of @entity5 600 mg. Transesophageal pacing was effective in interrupting @entity4 in 53% of @entity0 (8 of 15) in group A and in 87% of @entity0 (13 of 15) in group B. A significant lengthening of the flutter cycle was observed with respect to the baseline in @entity0 given @entity5 (261 +/- 23 vs 217 +/- 25, p < 0.01). Sinus rhythm resumed at a shorter paced cycle in group A @entity0 (166 +/- 13 vs 187 +/- 14 ms, p < 0.01). The transesophageal threshold for stable atrial capture was significantly lower in group A (20.5 +/- 0.2 vs 23.3 +/- 1.2, p < 0.01). In no @entity0 was the threshold for atrial capture higher than the @entity1 threshold. We did not observe abrupt enhancement of @entity2 . We conclude that @entity5 is effective and safe when used with transesophageal pacing in the termination of @entity4 . The slowing effect of the drug on intraatrial conduction and the possible stabilizing effect on the reentry circuit appear to be outweighed by the positive effect of @entity5 on the excitable gap of the circuit, facilitating its capture and accounting for the beneficial effect of the drug on @entity3 termination.

title: @entity4 termination by overdrive transesophageal pacing and the facilitating effect of oral XXXX .

answer: @entity5


abstract: BACKGROUND: Laparoscopic colorectal surgery has become the gold standard in the therapy of benignant and malignant colorectal pathologies. @entity4 is still a reason for laparotomy; applying a diverting stoma or performing a Hartman's procedure is common [1, 2]. Laparoscopic treatment of an early-detected @entity4 is suggested from other authors [3, 4]. In our video we demonstrate a combined minimal invasive transabdominal and transanal treatment concept in @entity0 with early-detected @entity4 . METHODS: Two consecutive @entity0 developing an @entity4 after single-port laparoscopic sigmoid resection for @entity1 (Hanson _ Stock) were treated with a combined minimal invasive approach. @entity4 was diagnosed by triple contrast computed tomography on postoperative day 4 in @entity0 one and on postoperative day 7 in @entity0 two. Operative treatment was performed immediately on the same day without delay. RESULTS: In both @entity0 a combined transanal and transabdominal approach was performed. First step was a diagnostic laparoscopy in order to exclude @entity3 . Using a single-port device (SILS    Port Covidien   ), transanal inspection of the @entity2 was also performed: In both @entity0 anastomotic tissue margins were vital, and the leakage affected only a quarter of the anastomotic circumference. Transanal stitches were placed to close the @entity4 . Laparoscopic transabdominal irrigation was performed, and two suction drainages were placed in the pelvis. Postoperative antibiotic treatment and a gradual return to slid food were carried out. Functional result at follow-up of 102 and 112  days (with rectoscopy) showed no residual leak and no stricture of the @entity2 , and both of @entity0 had a normal rectal function.

title: XXXX after laparoscopic single-port sigmoid resection: combined transanal and transabdominal minimal invasive management.

answer: @entity4


abstract: UNASSIGNED: Executioner @entity4 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. Therefore, we aimed at identifying novel functions of caspases in heart development. We induced simultaneous deletion of executioner @entity4 in the @entity0 myocardium and studied its effects. Caspase knockout hearts are @entity2 at birth, reaching normal weight progressively through @entity1 . To identify the molecular pathways involved in these effects, we used microarray-based transcriptomics and multiplexed quantitative proteomics to compare wild type and executioner @entity3 myocardium at different developmental stages. Transcriptomics showed reduced expression of genes promoting DNA replication and cell cycle progression in the neonatal @entity3 heart suggesting reduced myocyte proliferation, and expression of non-cardiac isoforms of structural proteins in the adult null myocardium. Proteomics showed reduced abundance of proteins involved in oxidative phosphorylation accompanied by increased abundance of glycolytic enzymes underscoring retarded metabolic maturation of the caspase-null myocardium. Correlation between mRNA expression and protein abundance of relevant genes was confirmed, but transcriptomics and proteomics indentified complementary molecular pathways influenced by caspases in the developing heart. Forced expression of wild type or proteolytically inactive caspases in cultured cardiomyocytes induced expression of genes promoting cell division. The results reveal that executioner caspases can modulate heart's cellularity and maturation during development, contributing novel information about caspase biology and heart development.

title: Executioner XXXX Deficiency Reduces Myocyte Number in the Developing @entity0 Heart.

answer: @entity4


abstract: UNASSIGNED: Executioner @entity4 are proteases promoting cell death but non-apoptotic roles are being discovered. The heart expresses caspases only during development, suggesting they contribute to the organ maturation process. Therefore, we aimed at identifying novel functions of caspases in heart development. We induced simultaneous deletion of executioner @entity4 in the @entity0 myocardium and studied its effects. Caspase knockout hearts are @entity2 at birth, reaching normal weight progressively through @entity1 . To identify the molecular pathways involved in these effects, we used microarray-based transcriptomics and multiplexed quantitative proteomics to compare wild type and executioner @entity3 myocardium at different developmental stages. Transcriptomics showed reduced expression of genes promoting DNA replication and cell cycle progression in the neonatal @entity3 heart suggesting reduced myocyte proliferation, and expression of non-cardiac isoforms of structural proteins in the adult null myocardium. Proteomics showed reduced abundance of proteins involved in oxidative phosphorylation accompanied by increased abundance of glycolytic enzymes underscoring retarded metabolic maturation of the caspase-null myocardium. Correlation between mRNA expression and protein abundance of relevant genes was confirmed, but transcriptomics and proteomics indentified complementary molecular pathways influenced by caspases in the developing heart. Forced expression of wild type or proteolytically inactive caspases in cultured cardiomyocytes induced expression of genes promoting cell division. The results reveal that executioner caspases can modulate heart's cellularity and maturation during development, contributing novel information about caspase biology and heart development.

title: Executioner @entity4 Deficiency Reduces Myocyte Number in the Developing XXXX Heart.

answer: @entity0


abstract: To study the immediate effects of prolonged @entity1 during PTCA, 41 @entity0 (44 lesions) with @entity3 were randomized for prolonged sequential inflations (three to five inflations of 3 to 5 min each, for a total duration of > or = 12 min, group 1, n = 20 lesions) or 'standard' sequential inflations (three to five inflations of < or = 1 min each, for a total duration of < or = 3 min, group 2, n = 24 lesions). The mean duration of @entity1 time was 958 +/- 129 s in group 1 vs 205 +/- 46 s in group 2. Results of angioplasty were assessed on both angiography and percutaneous transluminal coronary angioscopy performed immediately after the procedure. High quality imaging of the coronary lumen and lesion morphology was possible on angioscopy in all @entity0 without any complications. Post-PTCA angiographic percent diameter stenosis was significantly less in group 1 compared to group 2: 26 +/- 10% vs 36 +/- 8% (P < 0.05). On angioscopy, flaps were seen in 16 @entity0 in group 2, but in only six in group 1 (P < 0.02). There was no difference in the incidence of thrombi on angioscopy between the two groups (group 1: nine cases, group 2: 10 cases). Sensitivity of angiographic detection of flaps and thrombi was poor: 10% and 12% respectively. One @entity0 in each group developed a longitudinal dissection, detected on both angiography and angioscopy. CONCLUSIONS: (1) prolonged sequential balloon inflations lead to less @entity2 after PTCA, with a decreased incidence of intimal flaps in comparison with standard inflations. (2) Post-PTCA transluminal coronary angioscopy is safe and offers better assessment of luminal effects of PTCA than angiography.

title: Angioscopic evaluation of prolonged vs XXXX during coronary angioplasty. A randomized study.

answer: @entity1


abstract: The purpose of this study was to evaluate the characteristics of mitral annular motion during diastole in 28 normal subjects, 40 @entity0 with prior @entity2 ( @entity2 ), and 23 @entity0 with @entity1 but without prior @entity2 . Mitral annular motion during diastole was obtained from the apex by M-mode echocardiography at the posterior wall of the left ventricle. Determinants of mitral annular excursion during early (MAE-E) and late diastole ( @entity3 ) were investigated in all subjects. Differences in the MAE-E, @entity3 , and the @entity3 :MAE-E ratio were compared among the three @entity0 groups. The Doppler-derived transmitral flow velocity-time integral during early (EI) and late (AI) diastole and mitral annular excursions during diastole were obtained in 55 other @entity0 with a prior @entity2 and in 29 healthy volunteers. The relationships between the @entity3 :MAE-E ratio and AI:EI ratio in these two groups were studied. The MAE-E was determined mainly by heart rate and left ventricular ejection fraction (LVEF). The @entity3 was determined only by age. The magnitude of MAE-E was significantly less in @entity0 with a prior @entity2 than in normal subjects (P < 0.01). However, the @entity3 did not differ among the three groups. The @entity3 :MAE-E was higher in @entity0 with a prior @entity2 than in normal subjects (P < 0.05), and was significantly correlated with AI:EI in healthy volunteers (r = 0.65, P < 0.001) and in @entity0 with a prior @entity2 (r = 0.50, P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Diastolic mitral annular motion in normal subjects and @entity0 with XXXX .

answer: @entity1


abstract: The purpose of this study was to evaluate the characteristics of mitral annular motion during diastole in 28 normal subjects, 40 @entity0 with prior @entity2 ( @entity2 ), and 23 @entity0 with @entity1 but without prior @entity2 . Mitral annular motion during diastole was obtained from the apex by M-mode echocardiography at the posterior wall of the left ventricle. Determinants of mitral annular excursion during early (MAE-E) and late diastole ( @entity3 ) were investigated in all subjects. Differences in the MAE-E, @entity3 , and the @entity3 :MAE-E ratio were compared among the three @entity0 groups. The Doppler-derived transmitral flow velocity-time integral during early (EI) and late (AI) diastole and mitral annular excursions during diastole were obtained in 55 other @entity0 with a prior @entity2 and in 29 healthy volunteers. The relationships between the @entity3 :MAE-E ratio and AI:EI ratio in these two groups were studied. The MAE-E was determined mainly by heart rate and left ventricular ejection fraction (LVEF). The @entity3 was determined only by age. The magnitude of MAE-E was significantly less in @entity0 with a prior @entity2 than in normal subjects (P < 0.01). However, the @entity3 did not differ among the three groups. The @entity3 :MAE-E was higher in @entity0 with a prior @entity2 than in normal subjects (P < 0.05), and was significantly correlated with AI:EI in healthy volunteers (r = 0.65, P < 0.001) and in @entity0 with a prior @entity2 (r = 0.50, P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Diastolic mitral annular motion in normal subjects and XXXX with @entity1 .

answer: @entity0


abstract: OBJECTIVE: The aim of this study was to describe the management and outcome of @entity1 ( @entity1 ) after caustic ingestion. BACKGROUND: Emergency pulmonary patch repair has been reported to be lifesaving in @entity0 with caustic @entity1 . METHODS: @entity0 who underwent management of caustic @entity1 between 1989 and 2013, were included. @entity1 was defined as early if present on admission and late if occurring thereafter. Operative outcomes, long-term survival, and functional outcomes were compared with those of 269 @entity0 without @entity1 who underwent esophagectomy for @entity2 . RESULTS: Twenty @entity0 were included (10 @entity0 ; median age = 39 years). Early @entity1 was detected in 14 @entity0 , and late @entity1 occurred in 7 @entity0 , 8 days (range: 6-10 days) after admission. @entity1 involved the left bronchus (n = 17; 85%), the carina (n = 10; 50%), the supracarinal @entity3 (n = 9; 45%), the right bronchus (n = 4; 20%), and the cervical @entity3 (n = 3; 15%). Seventeen @entity0 underwent esophagogastrectomy, 2 underwent esophagectomy, and in 1 @entity0 , resection was eventually abandoned. Pulmonary patch repair was performed in 16 @entity0 (80%). Nine @entity0 (45%) died and morbidity was 100%. In univariate analysis, late @entity1 (P = 0.017) and acid ingestion (P = 0.002) were predictors of mortality. All survivors underwent restoring colopharyngoplasty. Five-year survival (28%) and functional success (25%) rates were significantly impaired when compared with esophagectomy @entity0 without @entity1 . CONCLUSIONS: @entity1 is one of the most devastating complications of caustic ingestion. Pulmonary patch repair is technically simple and can be lifesaving in this difficult situation.

title: XXXX After Caustic Ingestion.

answer: @entity1


abstract: BACKGROUND _ AIMS: @entity3 ( @entity3 ) is a poorly understood and potentially devastating complication of hepatic @entity5 ( @entity5 ) for @entity2 . Previous work has demonstrated that @entity0 ( @entity0 ) can ameliorate @entity3 in @entity1 . We hypothesized that @entity5 inhibits generation of cellular @entity4 and suppresses hepatic regeneration. METHODS: To study the metabolic changes that occur in @entity3 with and without @entity0 , @entity6 MRSI data were acquired in @entity1 treated with partial hepatectomy (PH) alone, PH with hepatic irradiation (PHRT) or PHRT with @entity0 (PHRT+ @entity0 ). RESULTS: Both [y - @entity4 ] and @entity4 /Pi @entity6 MRSI signal ratio initially decreased and subsequently returned to baseline levels within 2 weeks after PH, which is consistent with other published data. Persistently reduced [y- @entity4 ] and @entity4 /Pi @entity6 MRSI signal ratio were observed in @entity1 up to 20 weeks after PHRT. However, progressive increases in [y - @entity4 ] were observed over time in the group of @entity1 receiving PHRT+ @entity0 . Normal [y - @entity4 ] was observed 20 weeks after PHRT+ @entity0 (vs. PH alone), although, @entity4 /Pi levels did not return to normal after PHRT + @entity0 . Ex vivo histological studies were performed to confirm liver repopulation with transplanted hepatocytes and the amelioration of pathologic changes of @entity3 . CONCLUSIONS: These findings suggest that @entity6 MRSI can be used to monitor the progress of @entity3 and its amelioration using transplanted hepatocytes to simultaneously restore metabolic function while replacing host hepatocytes damaged by @entity5 .

title: Liver regeneration and energetic changes in @entity1 following hepatic @entity5 and XXXX by     P MRSI.

answer: @entity0


abstract: BACKGROUND _ AIMS: @entity3 ( @entity3 ) is a poorly understood and potentially devastating complication of hepatic @entity5 ( @entity5 ) for @entity2 . Previous work has demonstrated that @entity0 ( @entity0 ) can ameliorate @entity3 in @entity1 . We hypothesized that @entity5 inhibits generation of cellular @entity4 and suppresses hepatic regeneration. METHODS: To study the metabolic changes that occur in @entity3 with and without @entity0 , @entity6 MRSI data were acquired in @entity1 treated with partial hepatectomy (PH) alone, PH with hepatic irradiation (PHRT) or PHRT with @entity0 (PHRT+ @entity0 ). RESULTS: Both [y - @entity4 ] and @entity4 /Pi @entity6 MRSI signal ratio initially decreased and subsequently returned to baseline levels within 2 weeks after PH, which is consistent with other published data. Persistently reduced [y- @entity4 ] and @entity4 /Pi @entity6 MRSI signal ratio were observed in @entity1 up to 20 weeks after PHRT. However, progressive increases in [y - @entity4 ] were observed over time in the group of @entity1 receiving PHRT+ @entity0 . Normal [y - @entity4 ] was observed 20 weeks after PHRT+ @entity0 (vs. PH alone), although, @entity4 /Pi levels did not return to normal after PHRT + @entity0 . Ex vivo histological studies were performed to confirm liver repopulation with transplanted hepatocytes and the amelioration of pathologic changes of @entity3 . CONCLUSIONS: These findings suggest that @entity6 MRSI can be used to monitor the progress of @entity3 and its amelioration using transplanted hepatocytes to simultaneously restore metabolic function while replacing host hepatocytes damaged by @entity5 .

title: Liver regeneration and energetic changes in @entity1 following hepatic XXXX and @entity0 by     P MRSI.

answer: @entity5


abstract: BACKGROUND _ AIMS: @entity3 ( @entity3 ) is a poorly understood and potentially devastating complication of hepatic @entity5 ( @entity5 ) for @entity2 . Previous work has demonstrated that @entity0 ( @entity0 ) can ameliorate @entity3 in @entity1 . We hypothesized that @entity5 inhibits generation of cellular @entity4 and suppresses hepatic regeneration. METHODS: To study the metabolic changes that occur in @entity3 with and without @entity0 , @entity6 MRSI data were acquired in @entity1 treated with partial hepatectomy (PH) alone, PH with hepatic irradiation (PHRT) or PHRT with @entity0 (PHRT+ @entity0 ). RESULTS: Both [y - @entity4 ] and @entity4 /Pi @entity6 MRSI signal ratio initially decreased and subsequently returned to baseline levels within 2 weeks after PH, which is consistent with other published data. Persistently reduced [y- @entity4 ] and @entity4 /Pi @entity6 MRSI signal ratio were observed in @entity1 up to 20 weeks after PHRT. However, progressive increases in [y - @entity4 ] were observed over time in the group of @entity1 receiving PHRT+ @entity0 . Normal [y - @entity4 ] was observed 20 weeks after PHRT+ @entity0 (vs. PH alone), although, @entity4 /Pi levels did not return to normal after PHRT + @entity0 . Ex vivo histological studies were performed to confirm liver repopulation with transplanted hepatocytes and the amelioration of pathologic changes of @entity3 . CONCLUSIONS: These findings suggest that @entity6 MRSI can be used to monitor the progress of @entity3 and its amelioration using transplanted hepatocytes to simultaneously restore metabolic function while replacing host hepatocytes damaged by @entity5 .

title: Liver regeneration and energetic changes in XXXX following hepatic @entity5 and @entity0 by     P MRSI.

answer: @entity1


abstract: BACKGROUND: Although oral @entity3 has been used in some cases to reduce @entity2 in @entity0 , the use of this drug to reduce @entity2 after tonsillectomy has not been studied yet. METHODS: This double-blind clinical trial was conducted in 2009 in 92 @entity0 who were aged three to nine years old, met ASA I or II criteria, and were candidate for tonsillectomy. @entity0 were divided randomly into two groups. Half an hour before general anesthesia, 5 mg/kg @entity3 mixed in 2 cc/kg apple juice was given to the @entity0 in oral @entity3 group and 2 cc/kg of apple juice alone was given to the @entity0 in the peritonsillar group. After general anesthesia and three minutes before surgery 1 cc of 0.9% normal saline in the oral group and 1cc of @entity3 (0.5 mg/kg) in the peritonsillar group was injected to the tonsil bed of @entity0 . RESULTS: There was no difference between the two groups in terms of sex, age, and weight. Duration of surgery was significantly shorter in the peritonsillar group (P < 0.001) and the severity of @entity1 was significantly higher in peritonsillar group (P = 0.022). However, @entity1 recurred in 25 @entity0 (27%) and there was no statistically significant difference between the two groups. The level of @entity2 in @entity0 six hours after surgery according to CHEOPS criteria was significantly lower in the peritonsillar group (0.9    0.8) than in the oral group (2.6    1) (P < 0.001). CONCLUSIONS: The finding of this study showed that, compared with the peritonsillar infiltration of @entity3 , the use of oral @entity3 before general anesthesia was less effective in reducing postoperative @entity2 in @entity0 .

title: COMPARISON OF THE EFFECTS OF ORAL VS. PERITONSILLAR INFILTRATION OF XXXX IN PAIN REDUCTION AFTER TONSILLECTOMY: A RANDOMIZED CLINICAL TRIAL.

answer: @entity3


abstract: BACKGROUND: Histone H1, referred to as the linker histone, associates with the nucleosome core particle. While there is indication that the budding @entity0 version of histone H1 ( @entity1 ) contributes to regulation of chromatin structure and certain chromatin-related processes, such as DNA double-strand break repair, cells lacking @entity1 are healthy and display subtle phenotypes. A recent report has revealed that @entity1 is required for optimal sporulation. The studies described here were conducted to determine whether @entity1 influences meiotic recombination, an event that occurs during sporulation, involves generation and repair of DNA double-strand breaks, and is critical for spore viability. FINDINGS: Through tetrad analysis, cells with or without @entity1 were compared for meiotic reciprocal recombination events within several chromosome XV intervals. Parameters investigated included crossover frequency (genetic map distance) and crossover interference. No significant differences were detected between the two cell types. In agreement with earlier studies, spore viability was not affected by @entity1 absence. CONCLUSION: These data suggest that complete absence of @entity1 from chromatin does not affect reciprocal recombination between homologous chromosomes during meiosis. Therefore, the basal level of @entity1 that remains after its reported depletion early in meiosis is unlikely to be important for regulating recombination. Furthermore, the subsequent accumulation of @entity1 as the haploid products mature does not appear to be crucial for spore viability.

title: Evidence that histone H1 is dispensable for proper meiotic recombination in budding XXXX .

answer: @entity0


abstract: OBJECTIVE: Integration between descending and ascending inputs at supraspinal and spinal levels is a key characteristic of neural control of movement. In this study, we characterized convergence of the flexor reflex and corticospinal inputs on the tibialis anterior (TA) network in healthy @entity0 subjects. Specifically, we characterized the modulation profiles of the spinal TA flexor reflex following subthreshold and suprathreshold @entity2 ( @entity2 ). We also characterized the modulation profiles of the TA motor evoked potentials (MEPs) following medial arch foot stimulation at sensory and above reflex threshold. METHODS: TA flexor reflexes were evoked following stimulation of the medial arch of the foot with a 30ms pulse train at innocuous intensities. TA MEPs were evoked following @entity2 of the leg motor cortex area. RESULTS: @entity2 at 0.7 and at 1.2MEP resting threshold increased the TA flexor reflex when @entity2 was delivered 40-100ms after foot stimulation, and decreased the TA flexor reflex when @entity2 was delivered 25-110ms before foot stimulation. Foot stimulation at sensory and above flexor reflex threshold induced a similar time-dependent modulation in resting TA MEPs, that were facilitated when foot stimulation was delivered 40-100ms before @entity2 . The flexor reflex and MEPs recorded from the medial hamstring muscle were modulated in a similar manner to that observed for the TA flexor reflex and MEP. CONCLUSION: Cutaneomuscular afferents from the distal foot can increase the output of the leg motor cortex area. Descending motor volleys that directly or indirectly depolarize flexor motoneurons increase the output of the spinal FRA interneuronal network. The parallel facilitation of flexor MEPs and flexor reflexes is likely cortical in origin. SIGNIFICANCE: Afferent mediated facilitation of corticospinal excitability can be utilized to strengthen motor cortex output in @entity1 .

title: Convergence of flexor reflex and corticospinal inputs on tibialis anterior network in XXXX .

answer: @entity0


abstract: UNASSIGNED: The dynamic mutability of microsatellite repeats is implicated in the modification of gene function and disease phenotype. Studies of the enhanced instability of long trinucleotide repeats (TNRs)-the cause of multiple @entity0 diseases-have revealed a remarkable complexity of mutagenic mechanisms. Here, we show that cold, heat, @entity2 , and oxidative stresses induce mutagenesis of a long CAG repeat tract in @entity0 cells. We show that stress-response factors mediate the stress-induced mutagenesis (SIM) of CAG repeats. We show further that SIM of CAG repeats does not involve mismatch repair, @entity1 excision repair, or transcription, processes that are known to promote @entity4 mutagenesis in other pathways of instability. Instead, we find that these stresses stimulate DNA rereplication, increasing the proportion of cells with >4 C-value (C) DNA content. Knockdown of the replication origin-licensing factor @entity3 eliminates both stress-induced rereplication and CAG repeat mutagenesis. In addition, direct induction of rereplication in the absence of stress also increases the proportion of cells with >4C DNA content and promotes repeat mutagenesis. Thus, environmental stress triggers a unique pathway for @entity4 mutagenesis that likely is mediated by DNA rereplication. This pathway may impact normal cells as they encounter stresses in their environment or during development or abnormal cells as they evolve metastatic potential.

title: Environmental stress induces trinucleotide repeat mutagenesis in XXXX cells.

answer: @entity0


abstract: BACKGROUND: Previous studies have linked an increase in functional and pathological @entity1 following antecedent @entity2 ( @entity2 ), yet studies of other chronic @entity1 such as @entity4 ( @entity4 ) and @entity3 ( @entity3 ) are lacking. This study was performed to evaluate the association between documented @entity2 and the risk of @entity4 and @entity3 using a matched case-control study. METHODS: The odds of @entity2 (exposure) among subjects with @entity4 and @entity3 were compared to the odds of exposure in matched controls. Data were obtained from the Defense Medical Surveillance System. Incidence was estimated based on the number of active duty military personnel, and conditional logistic regression models were used to evaluate the relationship between @entity2 and @entity4 / @entity3 while adjusting for potential confounders. RESULTS: The overall incidence of @entity4 and @entity3 was 0.24 and 1.98 per 100,000 @entity0 -years, respectively. After adjusting for important covariates, prior @entity2 was associated with an increase in the odds of @entity4 (odds ratio (OR) 36.64) and @entity3 (OR 3.93) (p  <  0.001). Other covariates demonstrating an increased risk were being of Caucasian race, having greater than high school education, and service in military branches other than the Army. CONCLUSION: Overall, this study demonstrates the first significant estimates that a case of antecedent @entity2 is associated with an increased risk of @entity4 and @entity3 in an active duty military population. Ultimately, acquisition of @entity4 or @entity3 has the potential to decrease operational efficiency, which may have a significant impact on deployed military missions.

title: XXXX as a Risk Factor for @entity4 and Malabsorption: A Case-Control Study.

answer: @entity2


abstract: BACKGROUND: Previous studies have linked an increase in functional and pathological @entity1 following antecedent @entity2 ( @entity2 ), yet studies of other chronic @entity1 such as @entity4 ( @entity4 ) and @entity3 ( @entity3 ) are lacking. This study was performed to evaluate the association between documented @entity2 and the risk of @entity4 and @entity3 using a matched case-control study. METHODS: The odds of @entity2 (exposure) among subjects with @entity4 and @entity3 were compared to the odds of exposure in matched controls. Data were obtained from the Defense Medical Surveillance System. Incidence was estimated based on the number of active duty military personnel, and conditional logistic regression models were used to evaluate the relationship between @entity2 and @entity4 / @entity3 while adjusting for potential confounders. RESULTS: The overall incidence of @entity4 and @entity3 was 0.24 and 1.98 per 100,000 @entity0 -years, respectively. After adjusting for important covariates, prior @entity2 was associated with an increase in the odds of @entity4 (odds ratio (OR) 36.64) and @entity3 (OR 3.93) (p  <  0.001). Other covariates demonstrating an increased risk were being of Caucasian race, having greater than high school education, and service in military branches other than the Army. CONCLUSION: Overall, this study demonstrates the first significant estimates that a case of antecedent @entity2 is associated with an increased risk of @entity4 and @entity3 in an active duty military population. Ultimately, acquisition of @entity4 or @entity3 has the potential to decrease operational efficiency, which may have a significant impact on deployed military missions.

title: @entity2 as a Risk Factor for XXXX and Malabsorption: A Case-Control Study.

answer: @entity4


abstract: Social support and pet ownership, a nonhuman form of social support, have both been associated with @entity4 survival. The independent effects of pet ownership, social support, disease severity, and other psychosocial factors on 1-year survival after acute @entity5 are examined prospectively. The @entity6 Suppression Trial provided physiologic data on a group of post- @entity5 @entity0 with asymptomatic @entity6 . An ancillary study provided psychosocial data, including pet ownership, social support, recent life events, future life events, @entity1 , @entity3 , coronary prone behavior, and expression of anger. Subjects (n = 424) were randomly selected from @entity0 attending participating @entity6 Suppression Trial sites and completed baseline psychosocial questionnaires. One year survival data were obtained from 369 @entity0 (87%), of whom 112 (30.4%) owned pets and 20 (5.4%) died. Logistic regression indicates that high social support (p < 0.068) and owning a pet (p = 0.085) tend to predict survival independent of physiologic severity and demographic and other psychosocial factors. @entity2 owners (n = 87, 1 died) are significantly less likely to die within 1 year than those who did not own @entity2 (n = 282, 19 died; p < 0.05); amount of social support is also an independent predictor of survival (p = 0.065). Both pet ownership and social support are significant predictors of survival, independent of the effects of the other psychosocial factors and physiologic status. These data confirm and extend previous findings relating pet ownership and social support to survival among @entity0 with @entity4 .

title: Pet ownership, social support, and one-year survival after acute @entity5 in the XXXX Suppression Trial (CAST).

answer: @entity6


abstract: Social support and pet ownership, a nonhuman form of social support, have both been associated with @entity4 survival. The independent effects of pet ownership, social support, disease severity, and other psychosocial factors on 1-year survival after acute @entity5 are examined prospectively. The @entity6 Suppression Trial provided physiologic data on a group of post- @entity5 @entity0 with asymptomatic @entity6 . An ancillary study provided psychosocial data, including pet ownership, social support, recent life events, future life events, @entity1 , @entity3 , coronary prone behavior, and expression of anger. Subjects (n = 424) were randomly selected from @entity0 attending participating @entity6 Suppression Trial sites and completed baseline psychosocial questionnaires. One year survival data were obtained from 369 @entity0 (87%), of whom 112 (30.4%) owned pets and 20 (5.4%) died. Logistic regression indicates that high social support (p < 0.068) and owning a pet (p = 0.085) tend to predict survival independent of physiologic severity and demographic and other psychosocial factors. @entity2 owners (n = 87, 1 died) are significantly less likely to die within 1 year than those who did not own @entity2 (n = 282, 19 died; p < 0.05); amount of social support is also an independent predictor of survival (p = 0.065). Both pet ownership and social support are significant predictors of survival, independent of the effects of the other psychosocial factors and physiologic status. These data confirm and extend previous findings relating pet ownership and social support to survival among @entity0 with @entity4 .

title: Pet ownership, social support, and one-year survival after acute XXXX in the @entity6 Suppression Trial (CAST).

answer: @entity5


abstract: UNASSIGNED: @entity11 ( @entity11 ) is the second most lethal toxin known; it has been designated by the CDC as a select agent. @entity11 is made by the @entity10 plant; an estimated 50,000 tons of @entity11 are produced annually as a by-product of castor oil. @entity11 has two subunits, a ribotoxic A chain (RTA) and @entity8 -binding B chain (RTB). @entity11 binds to all @entity0 cells and once internalized, a single RTA catalytically inactivates all of the ribosomes in a cell. Administered as an aerosol, @entity11 causes rapid @entity5 and @entity2 followed by @entity4 . There are no Food and Drug Administration-approved vaccines and treatments are only effective in the first few hours after exposure. We have developed a recombinant RTA vaccine that has two mutations @entity12 / @entity13 (RiVax). The protein is expressed in @entity6 and is nontoxic and immunogenic in @entity1 , @entity3 , and @entity0 . When vaccinated @entity1 are challenged with injected, aerosolized, or orally administered (gavaged) @entity11 , they are completely protected. We have now developed a thermostable, @entity9 -adjuvant-containing formulation of RiVax and tested it in @entity7 . After three injections, the animals developed antibodies that completely protected them from a lethal dose of aerosolized @entity11 . These antibodies neutralized @entity11 and competed to varying degrees with a panel of neutralizing and nonneutralizing mouse monoclonal antibodies known to recognize specific epitopes on native RTA. The resulting antibody competition profile could represent an immunologic signature of protection. Importantly, the same signature was observed using sera from RiVax-immunized @entity0 .

title: Thermostable ricin vaccine protects XXXX against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.

answer: @entity7


abstract: BACKGROUND: In the UK, despite the import and use of all forms of asbestos being banned more than 15 years ago, the incidence of @entity3 continues to rise. Mesothelioma is almost invariably fatal, and more research is required, not only to find more effective treatments, but also to achieve an earlier diagnosis and improve palliative care. Following a debate in the House of Lords in July 2013, a package of measures was agreed, which included a James Lind Alliance Priority Setting Partnership, funded by the National Institute for Health Research. The partnership brought together @entity0 , carers, health professionals and support organisations to agree the top 10 research priorities relating to the diagnosis, treatment and care of @entity0 with @entity3 . METHODS: Following the established James Lind Alliance priority setting process, @entity3 @entity0 , current and bereaved carers, and health professionals were surveyed to elicit their concerns regarding diagnosis, treatment and care. Research questions were generated from the survey responses, and following checks that the questions were currently unanswered, an interim prioritisation survey was conducted to identify a shortlist of questions to take to a final consensus meeting. FINDINGS: Four hundred and fifty-three initial surveys were returned, which were refined into 52 unique unanswered research questions. The interim prioritisation survey was completed by 202 responders, and the top 30 questions were taken to a final meeting where @entity3 @entity0 , carers, and health professionals prioritised all the questions, and reached a consensus on the top 10. INTERPRETATION: The top 10 questions cover a wide portfolio of research (including assessing the value of immunotherapy, individualised chemotherapy, second-line treatment and immediate chemotherapy, monitoring @entity0 with @entity2 , defining the management of @entity1 , and optimising follow-up strategy). This list is an invaluable resource, which should be used to inform the prioritisation and funding of future @entity3 research.

title: Research priorities in XXXX : A James Lind Alliance Priority Setting Partnership.

answer: @entity3


abstract: BACKGROUND: Peak @entity1 uptake (V  O2peak) is a well-established prognostic marker in @entity4 ( @entity4 ). Cardiopulmonary exercise testing (CPET) provides physiological parameters other than V  O2peak that might have prognostic value. We aimed at determining whether exercise recovery data kinetics have prognostic implications over V  O2peak and @entity4 Survival Score. METHODS: Exercise data from 200 consecutive @entity4 @entity0 evaluated for possible heart transplantation and received CPET at our institution between 2004 and 2011 were analyzed. The rate of recovery of @entity1 uptake ( @entity5 ) at 2 minutes after exercise ( @entity5 - @entity7 ) was calculated using the difference between V  O2peak and @entity5 at minute 2 of recovery and expressed as a percentage of V  O2peak. The composite primary end point was the time from CPET to the first event including death, heart transplant, or mechanical heart implantation. RESULTS: Mean follow-up period was 1271    61 days during which there were 108 first events including 35 @entity2 , 66 heart transplants, and 7 mechanical heart implantations. The strongest prognostic factors in the univariate analysis were @entity5 - @entity7 , V  O2peak, @entity5 efficiency slope, and ventilation to @entity3 excretion ratio slope (all P < 0.0001). Multivariate analysis showed that @entity5 - @entity7 (P < 0.0001), ventilation to @entity3 excretion ratio slope (P  = 0.0022), use of @entity6 -converting enzyme inhibitors or angiotensin receptor blockers (P  = 0.0042), presence of a defibrillator (P  = 0.0127), and mean arterial pressure (P  = 0.0151) were independent predictors of event-free survival time. CONCLUSIONS: @entity5 - @entity7 was the strongest prognostic marker of death, heart transplantation, and mechanical heart implantation in severe @entity4 . This finding should be confirmed prospectively.

title: Prognostic Value of XXXX Kinetics During Recovery From Cardiopulmonary Exercise Testing in @entity0 with @entity4 .

answer: @entity1


abstract: BACKGROUND: Peak @entity1 uptake (V  O2peak) is a well-established prognostic marker in @entity4 ( @entity4 ). Cardiopulmonary exercise testing (CPET) provides physiological parameters other than V  O2peak that might have prognostic value. We aimed at determining whether exercise recovery data kinetics have prognostic implications over V  O2peak and @entity4 Survival Score. METHODS: Exercise data from 200 consecutive @entity4 @entity0 evaluated for possible heart transplantation and received CPET at our institution between 2004 and 2011 were analyzed. The rate of recovery of @entity1 uptake ( @entity5 ) at 2 minutes after exercise ( @entity5 - @entity7 ) was calculated using the difference between V  O2peak and @entity5 at minute 2 of recovery and expressed as a percentage of V  O2peak. The composite primary end point was the time from CPET to the first event including death, heart transplant, or mechanical heart implantation. RESULTS: Mean follow-up period was 1271    61 days during which there were 108 first events including 35 @entity2 , 66 heart transplants, and 7 mechanical heart implantations. The strongest prognostic factors in the univariate analysis were @entity5 - @entity7 , V  O2peak, @entity5 efficiency slope, and ventilation to @entity3 excretion ratio slope (all P < 0.0001). Multivariate analysis showed that @entity5 - @entity7 (P < 0.0001), ventilation to @entity3 excretion ratio slope (P  = 0.0022), use of @entity6 -converting enzyme inhibitors or angiotensin receptor blockers (P  = 0.0042), presence of a defibrillator (P  = 0.0127), and mean arterial pressure (P  = 0.0151) were independent predictors of event-free survival time. CONCLUSIONS: @entity5 - @entity7 was the strongest prognostic marker of death, heart transplantation, and mechanical heart implantation in severe @entity4 . This finding should be confirmed prospectively.

title: Prognostic Value of @entity1 Kinetics During Recovery From Cardiopulmonary Exercise Testing in @entity0 with XXXX .

answer: @entity4


abstract: BACKGROUND: Peak @entity1 uptake (V  O2peak) is a well-established prognostic marker in @entity4 ( @entity4 ). Cardiopulmonary exercise testing (CPET) provides physiological parameters other than V  O2peak that might have prognostic value. We aimed at determining whether exercise recovery data kinetics have prognostic implications over V  O2peak and @entity4 Survival Score. METHODS: Exercise data from 200 consecutive @entity4 @entity0 evaluated for possible heart transplantation and received CPET at our institution between 2004 and 2011 were analyzed. The rate of recovery of @entity1 uptake ( @entity5 ) at 2 minutes after exercise ( @entity5 - @entity7 ) was calculated using the difference between V  O2peak and @entity5 at minute 2 of recovery and expressed as a percentage of V  O2peak. The composite primary end point was the time from CPET to the first event including death, heart transplant, or mechanical heart implantation. RESULTS: Mean follow-up period was 1271    61 days during which there were 108 first events including 35 @entity2 , 66 heart transplants, and 7 mechanical heart implantations. The strongest prognostic factors in the univariate analysis were @entity5 - @entity7 , V  O2peak, @entity5 efficiency slope, and ventilation to @entity3 excretion ratio slope (all P < 0.0001). Multivariate analysis showed that @entity5 - @entity7 (P < 0.0001), ventilation to @entity3 excretion ratio slope (P  = 0.0022), use of @entity6 -converting enzyme inhibitors or angiotensin receptor blockers (P  = 0.0042), presence of a defibrillator (P  = 0.0127), and mean arterial pressure (P  = 0.0151) were independent predictors of event-free survival time. CONCLUSIONS: @entity5 - @entity7 was the strongest prognostic marker of death, heart transplantation, and mechanical heart implantation in severe @entity4 . This finding should be confirmed prospectively.

title: Prognostic Value of @entity1 Kinetics During Recovery From Cardiopulmonary Exercise Testing in XXXX with @entity4 .

answer: @entity0


abstract: UNASSIGNED: Conventional chemotherapy fails to cure metastatic @entity3 mainly due to its high hepatotoxicity. Currently, doxorubicin is the most widely used drug against @entity1 either as single agent or in combination with other chemotherapeutics like cisplatin. It is limited due to their severe @entity2 on normal hepatocytes. Therefore, alternative therapeutic agents without or with low hepatotoxicity are highly desirable. Interferons are a family of cytokines that potently demonstrate antiviral, immunomodulatory and anti-proliferative activities. It also exerts direct cytotoxic effects on @entity0 cells. The purpose of this study was to examine the in vitro @entity2 of interferon b on HepG2 cells. We revealed the presence of binding receptor of interferon b in HepG2 cells. The dose-dependent inhibition on cell proliferation was observed. We demonstrated that @entity6 exhibited significant @entity2 in HepG2 cells mainly through phosphorylation of signal transducers and activators of transcription2. The activation of Akt was suppressed. The stimulation of pro-apoptotic protein expression of @entity5 , inhibition of anti-apoptotic protein expression of @entity4 , activation of cleaved caspase 9 _ 3, was found at increasing concentrations. In conclusion, our results suggest that interferon b has potential to inhibit cell proliferation dose-dependently. Increased concentrations of interferon b influenced apoptosis via mitochondrial pathway through inhibition of p-Akt. This article is protected by copyright. All rights reserved.

title: Inhibitory effects of interferon b on XXXX HepG2 via Akt/STAT phosphorylation.

answer: @entity3


abstract: UNASSIGNED: In @entity0 with @entity1 ( @entity1 ), deposition of amyloid-beta Ab, a proteolytic cleavage of @entity2 ( @entity2 ) by b-secretase/ @entity5 , forms @entity3 in the brain. @entity5 activation is caused due to oxidative stresses and dysfunction of ubiquitin-proteasome system (UPS), which is linked to @entity4 inactivation. As partial suppression of @entity5 attenuates Ab generation and @entity1 -related pathology, it might be an ideal target for @entity1 treatment. We have shown that both in neurons and in HEK- @entity2 cells, @entity5 is a new substrate of E3-ligase CHIP and an inverse relation exists between CHIP and @entity5 level. CHIP inhibits ectopic @entity5 level by promoting its ubiquitination and proteasomal degradation, thus reducing @entity2 processing; it stabilizes @entity2 in neurons, thus reducing Ab. CHIP(U) (box) domain physically interacts with @entity5 ; however, both U-box and TPR domain are essential for ubiquitination and degradation of @entity5 . Further, @entity5 is a downstream target of @entity4 and overexpression of @entity4 decreases @entity5 level. In HEK- @entity2 cells, CHIP is shown to negatively regulate @entity5 promoter through stabilization of @entity4 's DNA-binding conformation and its binding upon 5' UTR element (+127 to +150). We have thus discovered that CHIP regulates @entity4 -mediated trans-repression of @entity5 at both transcriptional and post-translational level. We propose that a CHIP- @entity5 - @entity4 feedback loop might control @entity2 stabilization, which could further be utilized for new therapeutic intervention in @entity1 .

title: CHIP stabilizes XXXX via proteasomal degradation and @entity4 -mediated trans-repression of b-secretase.

answer: @entity2


abstract: UNASSIGNED: In @entity0 with @entity1 ( @entity1 ), deposition of amyloid-beta Ab, a proteolytic cleavage of @entity2 ( @entity2 ) by b-secretase/ @entity5 , forms @entity3 in the brain. @entity5 activation is caused due to oxidative stresses and dysfunction of ubiquitin-proteasome system (UPS), which is linked to @entity4 inactivation. As partial suppression of @entity5 attenuates Ab generation and @entity1 -related pathology, it might be an ideal target for @entity1 treatment. We have shown that both in neurons and in HEK- @entity2 cells, @entity5 is a new substrate of E3-ligase CHIP and an inverse relation exists between CHIP and @entity5 level. CHIP inhibits ectopic @entity5 level by promoting its ubiquitination and proteasomal degradation, thus reducing @entity2 processing; it stabilizes @entity2 in neurons, thus reducing Ab. CHIP(U) (box) domain physically interacts with @entity5 ; however, both U-box and TPR domain are essential for ubiquitination and degradation of @entity5 . Further, @entity5 is a downstream target of @entity4 and overexpression of @entity4 decreases @entity5 level. In HEK- @entity2 cells, CHIP is shown to negatively regulate @entity5 promoter through stabilization of @entity4 's DNA-binding conformation and its binding upon 5' UTR element (+127 to +150). We have thus discovered that CHIP regulates @entity4 -mediated trans-repression of @entity5 at both transcriptional and post-translational level. We propose that a CHIP- @entity5 - @entity4 feedback loop might control @entity2 stabilization, which could further be utilized for new therapeutic intervention in @entity1 .

title: CHIP stabilizes @entity2 via proteasomal degradation and XXXX -mediated trans-repression of b-secretase.

answer: @entity4


abstract: UNASSIGNED: @entity8 ( @entity8 )- @entity2 and the @entity7 state-are the most serious acute metabolic complications of @entity2 . We aimed to investigate the subsequent mortality after HCE in the non-elderly @entity2 which is still unclear. This retrospective national population-based cohort study reviewed, in Taiwan's National Health Insurance Research Database, data from 23,079 non-elder @entity0 ( <=65  years) with new-onset @entity2 between 2000 and 2002: 7693 @entity0 with HCE and 15,386 @entity0 without HCE (1:2). Both groups were compared, and follow-up prognoses were done until 2011. One thousand eighty-five (14.1  %) @entity0 with HCE and 725 (4.71  %) @entity0 without HCE died (P  <  0.0001) during follow-up. Incidence rate ratios (IRR) of mortality were 3.24 times higher in @entity0 with HCE than in @entity0 without HCE (P  <  0.0001). Individual analysis of @entity2 and @entity7 state also showed the similar result with combination of both. After stratification by age, mortality was significant higher in the middle age (40-64  years) [IRR 3.29; 95  % confidence interval (CI) 2.98-3.64] and young adult (18-39  years) (IRR 3.91; 95  % CI 3.28-4.66), but not in the pediatric subgroup (<18  years) (IRR 1.28; 95  % CI 0.21-7.64). The mortality risk was highest in the first month (IRR 54.43; 95  % CI 27.98-105.89), and still high after 8  years (IRR 2.05; 95  % CI 1.55-2.71). After adjusting for age, gender, and selected comorbidities, the mortality hazard ratio for @entity0 with HCE was still four times higher than for @entity0 without HCE. Moreover, older age, male gender, @entity3 , @entity1 , @entity6 , @entity5 , and @entity4 were independent mortality predictors. HCE significantly increases the subsequent mortality risk in the non-elderly with @entity2 . Strategies for prevention and control of comorbidities are needed as soon as possible.

title: Subsequent mortality after XXXX crisis episode in the non-elderly: a national population-based cohort study.

answer: @entity7


abstract: OBJECTIVE: To investigate whether combined chemoradiotherapy (CTRT) confers a benefit for survival outcome over radiotherapy (RT) alone after primary surgery in @entity0 with FIGO stage IIIC @entity3 . METHODS: We conducted a multicenter retrospective study of @entity0 with surgical stage IIIC endometrial cancer from 1990 to 2011. Adjuvant RT alone was performed in 85 @entity0 (40.3%) and adjuvant CTRT in 126 @entity0 (59.7%). @entity2 ( @entity2 ) and @entity4 ( @entity4 ) were analyzed using Kaplan-Meier method and Cox proportional hazards model. RESULTS: Stage IIIC1 and stage IIIC2 accounted for 63% and 37%, respectively. FIGO IIIC2 had a higher recurrence rate than FIGO IIIC1 (38.5% vs. 29.3%, p=0.172). Five-year @entity4 and @entity2 were lower in FIGO IIIC2 than FIGO IIIC1 (85.1% vs. 76.9%, p=0.417; 71.0% vs. 59.2%, p=0.108, respectively). Eighteen @entity0 (13.5%) in stage IIIC1 developed PALN recurrence, whereas only one (3.3%) in stage IIIC2 had PALN recurrence (p=0.001). In multivariate analysis, predictors of @entity2 were parametrial invasion (HR, 3.49; 95% CI, 1.83-6.64; p<0.001), higher grade (HR, 2.78; 95% CI, 1.31-5.89; p=0.008), and >3 positive pelvic nodes (HR, 1.84; 95% CI, 1.11-3.05; p=0.019). Combined CTRT did not affect @entity2 or @entity4 in IIIC1 and IIIC2 compared with RT alone. CONCLUSION: CTRT showed comparable survival outcome to RT alone. Half of relapses (46%) in stage IIIC1 occurred in PALN region, whereas relapse in stage IIIC2 primarily occurred in distant @entity1 (90%). Future randomized studies are needed to determine which subgroup may be most likely to benefit from CCRT.

title: A multicenter analysis of adjuvant therapy after surgery for stage IIIC XXXX : A Korean Radiation Oncology Group study (KROG 13-17).

answer: @entity3


abstract: OBJECTIVE: Our purpose was to determine whether vaginal @entity1 7 days rather than 3 days after @entity3 injection increases the percent of successful abortions on the day of @entity1 administration. STUDY DESIGN: A randomized controlled trial was performed in @entity0 requesting an abortion at < or = 56 days' gestation. Eighty-six @entity0 were treated with @entity3 50 mg/m2 intramuscularly followed 3 days (group 1) or 7 days (group 2) later by vaginal @entity1 800 micrograms. The @entity1 dose was repeated if the abortion did not occur. RESULTS: @entity6 occurred in 38 of 46 (83%) @entity0 in group 1 and 39 of 40 (98%) in group 2 (p = 0.033). Of the @entity0 with complete abortions, 30 of 46 (65%) in group 1 and 27 of 40 (68%) in group 2 aborted the same day as the first or second dose of @entity1 (p = 0.823). @entity5 lasted 14 +/- 5 (mean +/- SD) days in group 1 and 17 +/- 9 days in group 2. The remaining @entity0 aborted after a delay of 24 +/- 6 days in group 1 and 28 +/- 13 days in group 2. For these @entity0 vaginal @entity2 lasted 18 +/- 17 and 14 +/- 7 days, respectively, and the @entity0 chorionic gonadotropin-beta level was < or = 25 IU/L by 22 +/- 7 days after the abortion in group 1 and 19 +/- 9 days in group 2. Treatment failures in group 1 were four continuing pregnancies (9%), two @entity7 (4%), and two @entity0 who requested surgical termination after receiving both medications (4%). The treatment failure in group 2 was an @entity7 . @entity3 and @entity1 side effects were infrequent. CONCLUSIONS: @entity3 and vaginal @entity1 are more effective abortifacients when the @entity1 is given 7 days rather than 3 days after @entity3 . This treatment regimen may offer an alternative to surgical abortion or the use of antiprogestins and @entity4 for medical abortion.

title: A randomized trial comparing @entity1 three and seven days after XXXX for @entity6 .

answer: @entity3


abstract: OBJECTIVE: Our purpose was to determine whether vaginal @entity1 7 days rather than 3 days after @entity3 injection increases the percent of successful abortions on the day of @entity1 administration. STUDY DESIGN: A randomized controlled trial was performed in @entity0 requesting an abortion at < or = 56 days' gestation. Eighty-six @entity0 were treated with @entity3 50 mg/m2 intramuscularly followed 3 days (group 1) or 7 days (group 2) later by vaginal @entity1 800 micrograms. The @entity1 dose was repeated if the abortion did not occur. RESULTS: @entity6 occurred in 38 of 46 (83%) @entity0 in group 1 and 39 of 40 (98%) in group 2 (p = 0.033). Of the @entity0 with complete abortions, 30 of 46 (65%) in group 1 and 27 of 40 (68%) in group 2 aborted the same day as the first or second dose of @entity1 (p = 0.823). @entity5 lasted 14 +/- 5 (mean +/- SD) days in group 1 and 17 +/- 9 days in group 2. The remaining @entity0 aborted after a delay of 24 +/- 6 days in group 1 and 28 +/- 13 days in group 2. For these @entity0 vaginal @entity2 lasted 18 +/- 17 and 14 +/- 7 days, respectively, and the @entity0 chorionic gonadotropin-beta level was < or = 25 IU/L by 22 +/- 7 days after the abortion in group 1 and 19 +/- 9 days in group 2. Treatment failures in group 1 were four continuing pregnancies (9%), two @entity7 (4%), and two @entity0 who requested surgical termination after receiving both medications (4%). The treatment failure in group 2 was an @entity7 . @entity3 and @entity1 side effects were infrequent. CONCLUSIONS: @entity3 and vaginal @entity1 are more effective abortifacients when the @entity1 is given 7 days rather than 3 days after @entity3 . This treatment regimen may offer an alternative to surgical abortion or the use of antiprogestins and @entity4 for medical abortion.

title: A randomized trial comparing @entity1 three and seven days after @entity3 for XXXX .

answer: @entity6


abstract: OBJECTIVE: Our purpose was to determine whether vaginal @entity1 7 days rather than 3 days after @entity3 injection increases the percent of successful abortions on the day of @entity1 administration. STUDY DESIGN: A randomized controlled trial was performed in @entity0 requesting an abortion at < or = 56 days' gestation. Eighty-six @entity0 were treated with @entity3 50 mg/m2 intramuscularly followed 3 days (group 1) or 7 days (group 2) later by vaginal @entity1 800 micrograms. The @entity1 dose was repeated if the abortion did not occur. RESULTS: @entity6 occurred in 38 of 46 (83%) @entity0 in group 1 and 39 of 40 (98%) in group 2 (p = 0.033). Of the @entity0 with complete abortions, 30 of 46 (65%) in group 1 and 27 of 40 (68%) in group 2 aborted the same day as the first or second dose of @entity1 (p = 0.823). @entity5 lasted 14 +/- 5 (mean +/- SD) days in group 1 and 17 +/- 9 days in group 2. The remaining @entity0 aborted after a delay of 24 +/- 6 days in group 1 and 28 +/- 13 days in group 2. For these @entity0 vaginal @entity2 lasted 18 +/- 17 and 14 +/- 7 days, respectively, and the @entity0 chorionic gonadotropin-beta level was < or = 25 IU/L by 22 +/- 7 days after the abortion in group 1 and 19 +/- 9 days in group 2. Treatment failures in group 1 were four continuing pregnancies (9%), two @entity7 (4%), and two @entity0 who requested surgical termination after receiving both medications (4%). The treatment failure in group 2 was an @entity7 . @entity3 and @entity1 side effects were infrequent. CONCLUSIONS: @entity3 and vaginal @entity1 are more effective abortifacients when the @entity1 is given 7 days rather than 3 days after @entity3 . This treatment regimen may offer an alternative to surgical abortion or the use of antiprogestins and @entity4 for medical abortion.

title: A randomized trial comparing XXXX three and seven days after @entity3 for @entity6 .

answer: @entity1


abstract: BACKGROUND: @entity2 is one of the major health concerns in Southeast Asian countries, including Thailand. However, only a limited number of studies have been reported from this region. This study was designed to evaluate the prevalence, clinical characteristics and survival rate of @entity2 in Thailand. MATERIALS AND METHODS: Clinical information, histological features and endoscopic findings were collected from a tertiary care center in central region of Thailand between September 2011- November 2014 and reviewed. RESULTS: A total of 64 @entity2 @entity0 including 58 @entity0 and 6 @entity0 with mean age of 62.6 years were enrolled. Common presenting symptoms were @entity5 (74%), @entity6 (10%) and @entity8 (8%). Mean duration of symptoms prior to diagnosis was 72 days. @entity7 with contact bleeding was the most common endoscopic finding (55.6%). The location of @entity1 was found in proximal (16%), middle (50%) and distal (34%) esophagus. @entity4 was far more common histology than @entity3 (84.2% vs 10.5%). However, @entity3 was significantly more common than @entity4 in distal area of esophagus (100% vs 22.9%; p=0.0001, OR=1.6, 95%CI=1.1-2.2). @entity2 stages 3 and 4 accounted for 35.2% and 59.3% respectively. Overall 2-year survival rate was 20% and only 16% in metastatic @entity0 . CONCLUSIONS: Most @entity2 @entity0 in Thailand have @entity4 and nearly all present at advanced stage with a grave prognosis. Screening of high risk individuals and early detection might be important keys to improve the survival rate and treatment outcome in Thailand.

title: Late stage and grave prognosis of XXXX in Thailand.

answer: @entity2


abstract: @entity8 [ @entity8 ] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about @entity8 @entity1 , the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that @entity6 prevents hepatotoxicity induced by a single intraperitoneal injection of 15  mg/kg body weight (b.w.) of @entity10 ( @entity10 ). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from @entity0 treated with a hepatotoxic dose of @entity10 (15  mg/kg b.w.), and the effect of @entity6 pretreatment. @entity0 were divided into four groups: control, @entity6 , @entity10 , and @entity6 + @entity10 . At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. @entity10 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of @entity3 ( @entity4 ), @entity5 ( @entity7 ), and the activity of @entity2 dismutase (SOD), @entity9 ( @entity9 ), and related @entity7 enzymes were unchanged. As expected, @entity6 was safe. Lack of @entity10 -induced @entity1 in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15  mg/kg of @entity10 , that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.

title: Oxidative Stress Markers and Histological Analysis in Diverse Organs from @entity0 Treated with a Hepatotoxic Dose of XXXX : Effect of @entity6 .

answer: @entity8


abstract: @entity8 [ @entity8 ] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about @entity8 @entity1 , the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that @entity6 prevents hepatotoxicity induced by a single intraperitoneal injection of 15  mg/kg body weight (b.w.) of @entity10 ( @entity10 ). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from @entity0 treated with a hepatotoxic dose of @entity10 (15  mg/kg b.w.), and the effect of @entity6 pretreatment. @entity0 were divided into four groups: control, @entity6 , @entity10 , and @entity6 + @entity10 . At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. @entity10 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of @entity3 ( @entity4 ), @entity5 ( @entity7 ), and the activity of @entity2 dismutase (SOD), @entity9 ( @entity9 ), and related @entity7 enzymes were unchanged. As expected, @entity6 was safe. Lack of @entity10 -induced @entity1 in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15  mg/kg of @entity10 , that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.

title: Oxidative Stress Markers and Histological Analysis in Diverse Organs from @entity0 Treated with a Hepatotoxic Dose of @entity8 : Effect of XXXX .

answer: @entity6


abstract: @entity8 [ @entity8 ] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about @entity8 @entity1 , the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that @entity6 prevents hepatotoxicity induced by a single intraperitoneal injection of 15  mg/kg body weight (b.w.) of @entity10 ( @entity10 ). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from @entity0 treated with a hepatotoxic dose of @entity10 (15  mg/kg b.w.), and the effect of @entity6 pretreatment. @entity0 were divided into four groups: control, @entity6 , @entity10 , and @entity6 + @entity10 . At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. @entity10 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of @entity3 ( @entity4 ), @entity5 ( @entity7 ), and the activity of @entity2 dismutase (SOD), @entity9 ( @entity9 ), and related @entity7 enzymes were unchanged. As expected, @entity6 was safe. Lack of @entity10 -induced @entity1 in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15  mg/kg of @entity10 , that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.

title: Oxidative Stress Markers and Histological Analysis in Diverse Organs from XXXX Treated with a Hepatotoxic Dose of @entity8 : Effect of @entity6 .

answer: @entity0