abstract: The efficacy of systemic @entity7 in combination with cardiopulmonary bypass for the repair of @entity3 is established. Surface cooling in @entity0 with @entity5 as a prebypass adjunct has been associated with @entity2 . Surface cooling in @entity0 @entity4 with @entity5 results in increased systemic vascular resistance and unchanged pulmonary vascular resistance with increased left-to-right shunting and a maldistribution of blood flow away from the viscera and kidneys. This study was to determine whether @entity6 ameliorates the deleterious effects of increased systemic vascular resistance during @entity7 in @entity0 @entity4 with @entity5 . Nine neonatal @entity4 (4 weeks, 4 kg) had experimental @entity5 resulting in a 2.3 +/- 0.3: 1 shunt. Systemic and pulmonary vascular resistances were determined by the flow probe and microsphere techniques. Systemic and pulmonary blood flow distributions were measured by the microsphere technique. Left-to-right shunt ratios were determined by oximetry, flow probe, and microsphere. The @entity4 were cooled to 28 degrees C and measurements were made at 37 degrees, 32 degrees, and 28 degrees C. We found that @entity6 abolishes the deleterious effects of surface cooling by blocking the rise of systemic vascular resistance without significant changes in aortic pressure. As a result, the animals maintained control pulmonary-to-systemic flow levels and maintained control levels of @entity1 delivery while showing a decline in @entity1 consumption. Additionally, the vasodilatory effect allowed the animals to cool twice as fast as animals without @entity6 . Regional blood flow distribution as percent cardiac output and absolute tissue flow were protected during surface cooling. This technique may have a role in cardiac operations on @entity0 with left-to-right shunts.

title: @entity6 abolishes the deleterious effects of surface cooling-induced @entity7 on immature @entity4 with XXXX .

answer: @entity5


abstract: The efficacy of systemic @entity7 in combination with cardiopulmonary bypass for the repair of @entity3 is established. Surface cooling in @entity0 with @entity5 as a prebypass adjunct has been associated with @entity2 . Surface cooling in @entity0 @entity4 with @entity5 results in increased systemic vascular resistance and unchanged pulmonary vascular resistance with increased left-to-right shunting and a maldistribution of blood flow away from the viscera and kidneys. This study was to determine whether @entity6 ameliorates the deleterious effects of increased systemic vascular resistance during @entity7 in @entity0 @entity4 with @entity5 . Nine neonatal @entity4 (4 weeks, 4 kg) had experimental @entity5 resulting in a 2.3 +/- 0.3: 1 shunt. Systemic and pulmonary vascular resistances were determined by the flow probe and microsphere techniques. Systemic and pulmonary blood flow distributions were measured by the microsphere technique. Left-to-right shunt ratios were determined by oximetry, flow probe, and microsphere. The @entity4 were cooled to 28 degrees C and measurements were made at 37 degrees, 32 degrees, and 28 degrees C. We found that @entity6 abolishes the deleterious effects of surface cooling by blocking the rise of systemic vascular resistance without significant changes in aortic pressure. As a result, the animals maintained control pulmonary-to-systemic flow levels and maintained control levels of @entity1 delivery while showing a decline in @entity1 consumption. Additionally, the vasodilatory effect allowed the animals to cool twice as fast as animals without @entity6 . Regional blood flow distribution as percent cardiac output and absolute tissue flow were protected during surface cooling. This technique may have a role in cardiac operations on @entity0 with left-to-right shunts.

title: @entity6 abolishes the deleterious effects of surface cooling-induced XXXX on immature @entity4 with @entity5 .

answer: @entity7


abstract: The efficacy of systemic @entity7 in combination with cardiopulmonary bypass for the repair of @entity3 is established. Surface cooling in @entity0 with @entity5 as a prebypass adjunct has been associated with @entity2 . Surface cooling in @entity0 @entity4 with @entity5 results in increased systemic vascular resistance and unchanged pulmonary vascular resistance with increased left-to-right shunting and a maldistribution of blood flow away from the viscera and kidneys. This study was to determine whether @entity6 ameliorates the deleterious effects of increased systemic vascular resistance during @entity7 in @entity0 @entity4 with @entity5 . Nine neonatal @entity4 (4 weeks, 4 kg) had experimental @entity5 resulting in a 2.3 +/- 0.3: 1 shunt. Systemic and pulmonary vascular resistances were determined by the flow probe and microsphere techniques. Systemic and pulmonary blood flow distributions were measured by the microsphere technique. Left-to-right shunt ratios were determined by oximetry, flow probe, and microsphere. The @entity4 were cooled to 28 degrees C and measurements were made at 37 degrees, 32 degrees, and 28 degrees C. We found that @entity6 abolishes the deleterious effects of surface cooling by blocking the rise of systemic vascular resistance without significant changes in aortic pressure. As a result, the animals maintained control pulmonary-to-systemic flow levels and maintained control levels of @entity1 delivery while showing a decline in @entity1 consumption. Additionally, the vasodilatory effect allowed the animals to cool twice as fast as animals without @entity6 . Regional blood flow distribution as percent cardiac output and absolute tissue flow were protected during surface cooling. This technique may have a role in cardiac operations on @entity0 with left-to-right shunts.

title: @entity6 abolishes the deleterious effects of surface cooling-induced @entity7 on immature XXXX with @entity5 .

answer: @entity4


abstract: An asymptomatic 35 year-old @entity0 was referred to our hospital because of abnormal ECG findings. The ECG showed complete @entity3 and @entity7 . Echocardiography revealed a moderately enlarged right ventricle (RV) and an apical @entity2 . RV wall motion showed diffusely moderate impairment, while the systolic function of the left ventricle (LV) was slightly decreased. The ejection fractions (EF) of the RV and LV were calculated as 28.1% and 41.9% by Simpson's method using multiple cardiac computed tomography (CT) scans. A 24 hour ambulatory ECG showed only 372 single premature ventricular contractions (PVC). Cardiac catheterizaion revealed that the RV was enlarged with prominent trabeculation and decreased motion. In an electrophysiologic study, neither electrical stimulation of the RV nor electrical stimulation plus @entity9 infusion could induce @entity6 . Pathological examination of a biopsy from the interventricular septum of the RV revealed fibrofatty change in the myocardium. Based on these results, we made a diagnosis of @entity1 ( @entity1 ) and administered 5 mg of @entity8 . Sixty days after the initiation of @entity8 therapy, we performed repeat cardiac CT. The EF of the LV was markedly improved from 41.9% to 62.0%, although the EF of the RV was not changed. The number of PVCs showed no change. This case suggests that @entity8 is not only useful for controlling @entity4 but also for improving left ventriclular function in some @entity0 with @entity1 . Sympathetic overactivity is reported to cause @entity5 , so @entity8 may be a first-line drug for some @entity0 with @entity1 .

title: XXXX therapy improved left ventricular function in a @entity0 with arrhythmogenic right ventricular cardiomyopathy.

answer: @entity8


abstract: An asymptomatic 35 year-old @entity0 was referred to our hospital because of abnormal ECG findings. The ECG showed complete @entity3 and @entity7 . Echocardiography revealed a moderately enlarged right ventricle (RV) and an apical @entity2 . RV wall motion showed diffusely moderate impairment, while the systolic function of the left ventricle (LV) was slightly decreased. The ejection fractions (EF) of the RV and LV were calculated as 28.1% and 41.9% by Simpson's method using multiple cardiac computed tomography (CT) scans. A 24 hour ambulatory ECG showed only 372 single premature ventricular contractions (PVC). Cardiac catheterizaion revealed that the RV was enlarged with prominent trabeculation and decreased motion. In an electrophysiologic study, neither electrical stimulation of the RV nor electrical stimulation plus @entity9 infusion could induce @entity6 . Pathological examination of a biopsy from the interventricular septum of the RV revealed fibrofatty change in the myocardium. Based on these results, we made a diagnosis of @entity1 ( @entity1 ) and administered 5 mg of @entity8 . Sixty days after the initiation of @entity8 therapy, we performed repeat cardiac CT. The EF of the LV was markedly improved from 41.9% to 62.0%, although the EF of the RV was not changed. The number of PVCs showed no change. This case suggests that @entity8 is not only useful for controlling @entity4 but also for improving left ventriclular function in some @entity0 with @entity1 . Sympathetic overactivity is reported to cause @entity5 , so @entity8 may be a first-line drug for some @entity0 with @entity1 .

title: @entity8 therapy improved left ventricular function in a XXXX with arrhythmogenic right ventricular cardiomyopathy.

answer: @entity0


abstract: Overexpression of @entity3 and @entity4 receptors in @entity0 may be accompanied by contrasting clinical outcomes. To investigate the molecular mechanisms contributing to these differences, we undertook a comparative study of gene expression regulated by the two receptors. Agonistic antibodies were employed to activate @entity3 and @entity4 in isolation from the other ErbBs in @entity0 cells. Gene expression profiling using a 16 755-gene oligonucleotide array was performed to identify transcriptional targets of receptor activation. Our results indicate that, in the same cell line, @entity3 and @entity4 activation influence gene transcription differentially. Although there are genes that are regulated by signaling from both receptors, there are also receptor-specific targets that are preferentially regulated by each receptor. We further show that two ligands acting via the same receptor homodimer may activate different subsets of genes. Many of the induced genes are hitherto unidentified targets of @entity1 signaling. These include @entity4 targets @entity8 , @entity6 , and @entity5 and @entity3 -activated @entity2 / @entity2 and @entity7 . Targets of @entity3 homodimer signaling may be especially important as markers in @entity0 , where @entity3 homodimerization mediated by overexpression and ligand-independent activation is common.

title: Gene expression profiling of XXXX receptor and ligand-dependent transcription.

answer: @entity1


abstract: OBJECTIVES: To determine the incremental value of different strategies of both oral and intravenous beta-blockade during the perioperative period in high-risk vascular @entity0 in reducing costs and improving outcomes. DESIGN: Decision analytic model incorporating costs from provider's perspective INTERVENTIONS: Five perioperative strategies in @entity0 undergoing @entity3 surgery: (1). no routine beta-blockade, (2). preoperative oral @entity6 for 7 days followed by perioperative intravenous @entity4 and oral @entity6 based on preoperative titration, (3). immediate preoperative @entity5 with postoperative intravenous then oral @entity5 , (4). intraoperative @entity7 and postoperative intravenous then oral @entity5 , and (5). intraoperative and 18 hours of postoperative @entity7 then @entity5 . MEASUREMENTS AND MAIN RESULTS: Perioperative @entity1 was associated with a net increase of US dollars 21909 in charges to Medicare, whereas sustaining a perioperative @entity2 was associated with a net increase in charges of US dollars 15000. There is a net hospital saving of US dollars 500 using a strategy of titration of an oral beta-blocker medication for a minimum of 7 days, with a net increase in efficacy of 0.0304. All of the strategies involving acute perioperative blockade were associated with a net cost savings and increase in efficacy, although less than the strategy involving preoperative oral titration. CONCLUSION: Perioperative beta-blockade is both cost effective as well as efficacious from a short-term provider perspective. The optimal strategy of treatment for @entity0 who do not present to surgery already on beta-blockers requires further study, although all strategies save money even accounting for pharmaceutical costs.

title: Cost-effectiveness of differing perioperative beta-blockade strategies in vascular surgery XXXX .

answer: @entity0


abstract: OBJECTIVE: To explore the influence of @entity2 on clinical events after percutaneous coronary intervention (PCI). METHODS: We recruited 400 @entity0 that had undergone the percutaneous coronary intervention without complications in the Cardiology Department of Changhai Hospital consecutively from May 2011 to December 2012. The @entity0 were randomly assigned to receive anticoagulation therapy ( @entity2 ) or no anticoagulant. @entity0 were assessed for major adverse cardiac and cerebrovascular events (MACCEs) during hospitalization and at 1 and 12 months after PCI. RESULTS: There were no significant differences in the frequency of MACCEs between the two groups during hospitalization, at 1 month or 12 months post-PCI. During hospitalization, MACCEs occurred in 1.5% of the anticoagulation group versus 1.6% of the non-anticoagulation group (P>0.9). The groups had comparable rates of major @entity1 (3.6% vs 2.1%, P=0.37), but minor @entity1 was increased in the anticoagulation group (29.1% vs. 18.7%, P=0.016). At 1 month post-PCI, MACCEs occurred in 1.5% of the anticoagulation group and 2.6% of the non-anticoagulation group, (P=0.5), and at 12 months post-PCI, the rates were 5.6% vs. 6.2%, respectively (P=0.8). CONCLUSIONS: The frequency of MACCEs after PCI in the non-anticoagulation group was not significantly increased compared with that of the anticoagulation group. However, the rate of minor @entity1 during hospitalization is significantly lower in non-anticoagulation group than that in anticoagulation group. The results suggest that routine anticoagulation therapy after PCI is not necessary for @entity0 without procedure complications.

title: Effect of XXXX on clinical events after percutaneous coronary intervention.

answer: @entity2


abstract: UNASSIGNED: The trial was to explore the effects of Chinese medicinal plants (CMP) treatment on the advanced @entity1 (stage III-IV) after conservative surgery. A prospective, multi-center and controlled trial was conducted from June 2012 to September 2013. Sixty-five post-operative @entity0 with advanced @entity1 (stage III-IV) after conservative surgery were included in the trial. They had undergone laparoscopic surgical excision of the @entity2 and the diagnosis of @entity1 was confirmed by pathological examination. The @entity0 received either CMP treatment or @entity4 sustained-release depot treatment (as comparison) according to the willingness of the @entity0 . In the post-treatment follow-up visit at 6 and 12 months, the @entity0 were respectively undergone ultrasonic and gynecological examinations. The serum levels of cancer antigen 125 (CA-125) and @entity3 ( @entity3 ) were also detected in the post-treatment follow-up visit at 12 months. We found that in the post-treatment follow-up visit at 6 months, the recurrence rate of CMP group and comparison group was 1/31 (3.23%) and 1/34 (2.94%), respectively. In the post-treatment follow-up visit at 12 months, the recurrence rate of CMP group and comparison group was 5/31 (16.13%) and 6/34 (17.65%), respectively. There were no significant differences between the two groups (P>0.05). The serum levels of CA-125 and @entity3 significantly decreased in both of the two groups (P<0.05) and no marked differences existed between them on the serum levels of @entity3 (P>0.05). The serum CA-125 levels of CMP group were significantly lower than those of the comparison group (P<0.05). No adverse effect was reported in both of the two groups during the research and the follow-up period. It concluded that CMP showed promise in preventing the recurrence of stage III-IV @entity1 after conservative surgery, although the conclusion is somewhat limited due to the small size of the trial.

title: Chinese medicinal plants for advanced XXXX after conservative surgery: a prospective, multi-center and controlled trial.

answer: @entity1


abstract: UNASSIGNED: @entity12 ( @entity12 ) and @entity11 are two common disorders of the thyroid. Despite their benign nature, both conditions are associated with multiple pathologic conditions including @entity10 , and @entity7 . In this study we conducted a large-scale epidemiological study in Chinese @entity0 to identify risk factors implicated in the pathogenesis of @entity12 and @entity11 . We analyzed demographic data, medical history, menstrual status, smoking, @entity5 consumption, body height, weight, waist circumference, and body mass index (BMI). Thyroid ultrasonography was performed for all subjects. Our results showed that age, menstrual status, BMI, waist circumference, @entity2 , @entity8 and @entity9 had a significant relationship with the prevalence of @entity12 and @entity11 . There was also a significant association between parity, educational level, smoking, seafood consumption, salt consumption and @entity12 . Waist-hip ratio, BMI, and @entity6 had a significant association with both @entity12 and @entity11 , and total @entity3 only correlated with @entity12 . Medical management of @entity2 significantly affected @entity12 prevalence. Our study also demonstrated age to be a strong predictor of @entity12 and @entity11 , and @entity1 a predictor of the likelihood of developing @entity11 . Thus, our study suggests that the female Chinese population with advance age, menopause, @entity1 and @entity4 be examined for @entity12 and @entity11 , and those @entity0 with confirmed @entity12 and @entity11 be screened for age and @entity1 related disorders such as @entity4 .

title: An epidemiological study of risk factors of thyroid nodule and XXXX in Chinese @entity0 .

answer: @entity11


abstract: UNASSIGNED: @entity12 ( @entity12 ) and @entity11 are two common disorders of the thyroid. Despite their benign nature, both conditions are associated with multiple pathologic conditions including @entity10 , and @entity7 . In this study we conducted a large-scale epidemiological study in Chinese @entity0 to identify risk factors implicated in the pathogenesis of @entity12 and @entity11 . We analyzed demographic data, medical history, menstrual status, smoking, @entity5 consumption, body height, weight, waist circumference, and body mass index (BMI). Thyroid ultrasonography was performed for all subjects. Our results showed that age, menstrual status, BMI, waist circumference, @entity2 , @entity8 and @entity9 had a significant relationship with the prevalence of @entity12 and @entity11 . There was also a significant association between parity, educational level, smoking, seafood consumption, salt consumption and @entity12 . Waist-hip ratio, BMI, and @entity6 had a significant association with both @entity12 and @entity11 , and total @entity3 only correlated with @entity12 . Medical management of @entity2 significantly affected @entity12 prevalence. Our study also demonstrated age to be a strong predictor of @entity12 and @entity11 , and @entity1 a predictor of the likelihood of developing @entity11 . Thus, our study suggests that the female Chinese population with advance age, menopause, @entity1 and @entity4 be examined for @entity12 and @entity11 , and those @entity0 with confirmed @entity12 and @entity11 be screened for age and @entity1 related disorders such as @entity4 .

title: An epidemiological study of risk factors of thyroid nodule and @entity11 in Chinese XXXX .

answer: @entity0


abstract: Growth hormone plays a central role in the change in nutrient metabolism that occurs during the initiation of lactation. The actions of growth hormone are mediated by the growth hormone receptor (GHR) whose mRNA is present in three alternatively spliced forms (GHR 1A, 1B, and 1C). Liver-specific GHR 1A mRNA is transiently decreased around parturition, but the exact timing of the decline is not known. Our objective was to generate a daily profile for total GHR (GHRtot; all GHR transcripts), GHR 1A, and @entity5 mRNA expression in liver of periparturient Holstein @entity1 and evaluate these daily mRNA profiles relative to daily profiles for periparturient hormones and metabolites. Liver biopsies and blood samples (n = 139) were collected from 65 Holstein @entity1 at the University of Missouri Dairy Farm. At least two @entity1 were sampled on each day from 14 d before to 14 d after parturition. Total cellular RNA was isolated and reverse transcribed to cDNA. Target cDNA were measured by quantitative real-time polymerase chain reaction. Plasma was assayed for @entity3 , @entity0 , insulin, growth hormone, @entity5 , @entity2 , and nonesterified @entity4 . The GHR 1A mRNA declined 2 d before parturition, was lowest 3 to 4 d after parturition, and then increased. The @entity5 mRNA declined 1 d after parturition, was lowest 2 to 5 d after parturition and then increased. Total GHR mRNA was not affected by day. The decrease in GHR 1A mRNA was associated with a decrease in @entity3 and an increase in @entity0 shortly before parturition. A detailed profile of GHR 1A, @entity5 , and GHRtot mRNA expression during the periparturient period was provided. The decreases in GHR 1A and @entity5 during the transition period occurred immediately before (GHR 1A) or shortly after ( @entity5 ) parturition. Rapid changes in placental and ovarian steroids before parturition were coincident with changes in GHR 1A mRNA.

title: Plasma hormones and expression of growth hormone receptor and insulin-like growth factor-I mRNA in hepatic tissue of periparturient dairy XXXX .

answer: @entity1


abstract: Ninety-one Ontario Holstein dairy herds were surveyed about their lactating @entity0 ration and use of a premix containing monensin to identify possible dietary interactions with monensin on milk fat suppression. All herds were enrolled in Ontario Dairy Herd Improvement (DHI) milk recording, and results from four DHI tests were used. Herd mean fat tests were calculated only for @entity0 between 100 and 200 d in milk to avoid potential confounding due to stage of lactation. Wet forage and total mixed ration (TMR) samples from all herds were evaluated for particle size using the Penn State Particle Size Separator. Of the herds using monensin (n = 58), the dose (per kg of dry matter) ranged from 9 to 14 mg/kg in TMR-fed herds and from approximately 9 to 23 mg/kg in herds in which concentrates were fed separately from forages (component-fed). Of the samples submitted for particle size evaluation, 15% of the haylage (n = 80), 14% of the @entity2 silage (n = 79), and 42% of the TMR (n = 58) samples were classified as having low fiber. There was a significant negative univariable association between monensin and mean milk fat percentage. Monensin significantly reduced milk fat percentage in TMR-fed but not component-fed herds. Fiber length significantly interacted with monensin in TMR-fed herds: Herds that had low fiber in their TMR (< or = 6.0% in the top screen) were susceptible to milk fat decrease by @entity3 , whereas herds that had adequate fiber (> 6.0%) were not. @entity3 also significantly reduced milk fat percentage in herds receiving diets low in nonstructural @entity1 (< 40.2%) but not in those receiving diets high in NSC (> or = 40.2%). The results of this study suggest that there are significant interactions between monensin and certain dietary factors on milk fat suppression in Holstein dairy herds.

title: A field study of dietary interactions with monensin on milk fat percentage in lactating dairy XXXX .

answer: @entity0


abstract: Environmental legislation has made it necessary for livestock producers to be able to quantify and adjust the N balance on their farms. @entity2 balance and efficiencies were computed for 41 commercial dairies in Utah and Idaho using the University of Maryland Nutrient Balancer. The average N balance, or unaccounted for N, was 81 tonnes per year for the average herd size of 466 @entity0 with 35.8% of the inputs accounted for in the outputs. The major inputs for farms that grew crops (n = 23, herd size = 284 total @entity0 ) were imported feed (57.4% of all inputs) and @entity1 fixation (30% of inputs). The major outputs were animal products (primarily milk and some meat, 80% of outputs). For farms that grew no crops (n = 18, herd size = 700 total @entity0 ), 98% of the inputs were from imported feed. Of the outputs, 57% of the N was in animal products and 42.9% in manure and compost. Whole-farm balance per product for those farms that grew crops was most affected by herd N utilization efficiency (kg feed N per kg product N), crop N utilization efficiency, and availability of manure N applied to crops, while manure N storage efficiency was of lesser importance. For farms that grew no crops, whole-farm N balance per product was most affected by herd N utilization efficiency and manure N storage efficiency. Maximizing conversion of feed N to product N was the best way to reduce whole-farm N balance.

title: Whole-farm XXXX balance on western dairy farms.

answer: @entity1


abstract: Studies were undertaken on seven adult female buffaloes ( @entity3 ) premedicated with @entity6 (0.3 mg/kg) and @entity5 (30 mg/kg). Anaesthesia was induced with @entity4 (10 mg/kg) and animals were kept under intermittent positive pressure ventilation. Measurements were made for 30 min in the lateral position, for 20 min in the supine position and subsequently for 40 min again in the lateral position. @entity1 during anaesthesia was avoided by evacuation of the rumen by rumenotomy two days prior to the experiment. When animals were in the lateral position there were minimal changes in arterial pressure and heart rate but central venous pressure rose. These changes were related to intermittent positive pressure ventilation. In the supine position, increase in heart rate (28%) was associated with profound @entity2 (56%) and decrease in central venous pressure (171%) in these animals. There was a fall in venous @entity0 tension and a marked increase (91%) in @entity0 extraction ratio. Restoration to the lateral position ameliorated all these changes rapidly. It was suggested that a 'low pressure-low flow' circulatory state exists in anaesthetised adult buffaloes in the supine position.

title: Haemodynamic and blood gas changes in buffaloes ( XXXX ) in the supine position following thiopentone anaesthesia with premedication.

answer: @entity3


abstract: OBJECTIVES: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure that has revolutionized the diagnosis and @entity2 . The goal of the present study was to investigate the yield and applicability of molecular testing in the specimens obtained by EBUS-TBNA from @entity0 with advanced @entity5 ( @entity5 ), comparing the results with a series of @entity0 who underwent diagnostic surgical procedures in the same institution. METHODS: The study followed 306 consecutive @entity0 with clinically diagnosed primary @entity1 who had the EBUS-TBNA procedure. @entity3 and @entity4 mutations were evaluated on cytologic specimens by Sanger sequencing and Cobas real-time polymerase chain reaction, whereas @entity6 rearrangement was tested by fluorescence in situ hybridization. The results were compared with those obtained from a series of 1,000 @entity5 surgical samples routinely analyzed. RESULTS: Molecular testing was possible in 96.9% of the samples obtained by EBUS-TBNA. @entity3 (exons 18-21) mutations were found in 16.9%, @entity4 mutation (exons 2-3) in 31.6%, and @entity6 rearrangement in 3.9% of the cases. In the surgical series, the mutations' distribution were 14.8%, 29.0%, and 3.4%, respectively. There were no statistical differences between the two series. CONCLUSIONS: Our study demonstrates that EBUS-TBNA can be effectively used not just for diagnosis but also for complete mutational testing.

title: Molecular Testing for Targeted Therapy in Advanced XXXX : Suitability of Endobronchial Ultrasound Transbronchial Needle Aspiration.

answer: @entity5


abstract: Survivors of @entity1 ( @entity1 ) in childhood have been identified with balance problems. The goals of this study were to objectively quantify these observations by measuring the displacement and velocity of the body centre of pressure, a measure of 'sway'. The subjects included 79 @entity1 survivors who were at least 1 year post-treatment for @entity1 and 83 age-matched controls. Testing was carried out using various static balance tests designed to challenge central nervous system maintenance of balance and postural control. @entity0 were different from controls, across all age groups, in the more difficult task in which they were required to balance over a narrow base of support. However this did not reach statistical significance. When they were asked to perform this task with their eyes closed 32% of the @entity0 tested, as opposed to 2% of controls, were unable to complete the task (significant at P<0.01, chi(2)). The youngest group of @entity0 ( @entity0 aged 5-7 years) presented consistently with lower (or similar) displacement and lower velocity measures. This phenomenon has been observed in healthy @entity0 , however, in @entity0 , these trends were magnified and beyond the normal age range in healthy @entity0 . The velocity values were significantly different from the other @entity0 groups (normalized values for velocity; P<0.01). These observations then manifested as higher sway values when @entity0 were challenged with a difficult task with their eyes closed. We propose that survivors of childhood @entity1 have delayed motor development compared to age-matched controls giving rise to impairment in balance and postural control. It is possible that these impairments are a consequence of intensive multi-agent chemotherapy and cranial irradiation.

title: Measurement of balance in survivors of XXXX in childhood.

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) is a common medical condition in middle-aged and elderly @entity0 ; however, large-scale and multi-center epidemiologic studies about the treatment effects on @entity1 in China are lacking. OBJECTIVE: To elucidate the efficacy and safety of a phosphodiesterase type 5 inhibitor (PDE5-i) in the treatment of @entity0 with @entity1 in China. METHODS: @entity0 clinically diagnosed with @entity1 from 53 andrology centers in 15 metropolitan areas in China who were willing to undergo treatment for @entity1 were enrolled in the study. Each @entity0 received 4 weeks of unique PDE5-i treatment, and completed the following forms (International Index of Erectile Function score 5 [IIEF-5], the Erection Hardness Score [EHS], Self-Esteem and Relationship [SEAR], and SF-36 of Health Related Quality of Life). Pre-and post-treatment data were compared using descriptive analysis. RESULTS: A total of 1956 @entity1 @entity0 were included in this study; 1922 @entity0 provided valid questionnaires for analysis. Four weeks of @entity2 treatment was considered effective and safe. Specifically, the IIEF-5 sores (11.30    3.7 vs. 20.02    5.1, P < 0.05), EHS levels (99.1% @entity0 increases to level 3 or 4), and the SEAR scores (32.5 vs. 55.1, P < 0.05) were significantly improved compared to baseline. @entity2 therapy also significantly improved the satisfaction, enjoyment, and frequency of sexual attempts and sexual activity, as well as physical vigor and mental health scores. CONCLUSION: The present study provides direct evidence regarding the efficacy and safety of @entity2 therapy in a large sample of Chinese @entity0 with @entity1 , thus verifying that @entity2 improved the symptoms and quality of sexual life.

title: Effect of @entity2 on XXXX and improvement in the quality of sexual life in China: a multi-center study.

answer: @entity1


abstract: BACKGROUND: @entity1 ( @entity1 ) is a common medical condition in middle-aged and elderly @entity0 ; however, large-scale and multi-center epidemiologic studies about the treatment effects on @entity1 in China are lacking. OBJECTIVE: To elucidate the efficacy and safety of a phosphodiesterase type 5 inhibitor (PDE5-i) in the treatment of @entity0 with @entity1 in China. METHODS: @entity0 clinically diagnosed with @entity1 from 53 andrology centers in 15 metropolitan areas in China who were willing to undergo treatment for @entity1 were enrolled in the study. Each @entity0 received 4 weeks of unique PDE5-i treatment, and completed the following forms (International Index of Erectile Function score 5 [IIEF-5], the Erection Hardness Score [EHS], Self-Esteem and Relationship [SEAR], and SF-36 of Health Related Quality of Life). Pre-and post-treatment data were compared using descriptive analysis. RESULTS: A total of 1956 @entity1 @entity0 were included in this study; 1922 @entity0 provided valid questionnaires for analysis. Four weeks of @entity2 treatment was considered effective and safe. Specifically, the IIEF-5 sores (11.30    3.7 vs. 20.02    5.1, P < 0.05), EHS levels (99.1% @entity0 increases to level 3 or 4), and the SEAR scores (32.5 vs. 55.1, P < 0.05) were significantly improved compared to baseline. @entity2 therapy also significantly improved the satisfaction, enjoyment, and frequency of sexual attempts and sexual activity, as well as physical vigor and mental health scores. CONCLUSION: The present study provides direct evidence regarding the efficacy and safety of @entity2 therapy in a large sample of Chinese @entity0 with @entity1 , thus verifying that @entity2 improved the symptoms and quality of sexual life.

title: Effect of XXXX on @entity1 and improvement in the quality of sexual life in China: a multi-center study.

answer: @entity2


abstract: OBJECTIVE: To compare the platelet to lymphocyte ratio (PLR) in normal @entity0 , @entity3 ( @entity3 ) @entity0 and @entity1 ( @entity1 ) @entity0 , and to explore the prognostic role of PLR in @entity1 . METHODS: 155 normal @entity0 , 168 @entity3 @entity0 and 103 @entity1 @entity0 were enrolled. @entity1 @entity0 were divided into PLR low value group (PLR<150) and PLR high value group (PLR>= 150), and the difference of @entity0 ' clinical characteristics between high value group and low value group was comparative studied. RESULTS: The differences of PLR among normal @entity0 , @entity3 @entity0 and @entity1 @entity0 were statistically significant. In addition, platelet counts, neutrophil counts, PSA level, LDH level, AKP level, CRP level and alkaline phosphatase level were also significantly increased in PLR high value group, while the hemoglobin level was decreased. Besides, serious events such as @entity2 during hospitalization were also more likely to appear in PLR high value group. @entity1 @entity0 had an average follow-up of 3 years, and a total of 25 cases of @entity0 died, including 11 (16.4%) cases in the PLR low value group, and 14 (38.9%) cases in PLR high value group with. Three years survival rate of @entity0 in high value group was significantly reduced. Additionally, PLR was a possible risk factor associated with mortality, and an independent predictor of all-cause mortality during follow-up. CONCLUSION: PLR is significantly increased in @entity1 @entity0 , and it is an independent predictor of 3-year mortality in @entity1 @entity0 .

title: Platelet to lymphocyte ratio plays an important role in XXXX 's diagnosis and prognosis.

answer: @entity1


abstract: AIM: To initially test for the content validity, comprehensibility, test-retest reliability and internal consistency reliability of the Yin-Yang Assessment Questionnaire (YY-AQ). METHODS: The process of initial validity and reliability test covered: (1) content validation from the findings of 18 multiple-case studies, validated Yin- and @entity2 assessment questionnaires, relevant literatures and registered Chinese medicine practitioners; (2) comprehension with the levels of comprehensibility for each item categorized on a 3-point scale (not comprehensible; moderately comprehensible; highly comprehensible). A minimum of three respondents selecting for each item of moderately or highly comprehensible were regarded as comprehensive; (3) test-retest reliability conducted with a 2-wk interval. The intraclass correlation coefficients (ICCs) and their 95%CIs were calculated using a two-way random effects model. Wilcoxon Signed Rank test for related samples was adopted to compare the medians of test-retest scores. An ICC value of 0.85 or higher together with P > 0.05, was considered acceptable; and (4) internal consistency of the total items was measured and evaluated by Cronbach's coefficient alpha (a). A Cronbach's a of 0.7 or higher was considered to represent good internal consistency. RESULTS: Eighteen @entity3 and 14 @entity2 presentation items were finalized from content validation. Five @entity0 with @entity1 ( @entity1 ) performed the comprehensibility and test-retest reliability tests. Comprehensibility score level of each presentation item was found to be moderate or high in three out of the five @entity0 . Test-retest reliability showed that the single measure ICC of the total @entity3 presentation items was 0.99 (95%CI: 0.89-0.99) and the median scores on the first and 14(th) days were 17 (IQR 6.5-27) and 21 (IQR 6-29) (P = 0.144) respectively. The single measure ICC of the total @entity2 presentation items was 0.88 (95%CI: 0.79-0.99) and the median scores on the first and 14(th) days were 10 (IQR 6-18) and 14 (IQR 7-23) (P = 0.144) respectively. The results of a descriptive correlation study on 140 survey @entity0 with @entity1 using the YY-AQ showed that internal consistency of the total @entity3 and @entity2 presentation items was satisfactory, with Cronbach's a of 0.79 and 0.78 respectively. CONCLUSION: The YY-AQ will be tested further for comprehensibility, test-retest and internal consistency reliabilities, scoring system validity, construct validity, convergent and discriminant validities, responsiveness and predictive validity.

title: Initial validation of the Yin-Yang Assessment Questionnaire for @entity0 with XXXX .

answer: @entity1


abstract: AIM: To initially test for the content validity, comprehensibility, test-retest reliability and internal consistency reliability of the Yin-Yang Assessment Questionnaire (YY-AQ). METHODS: The process of initial validity and reliability test covered: (1) content validation from the findings of 18 multiple-case studies, validated Yin- and @entity2 assessment questionnaires, relevant literatures and registered Chinese medicine practitioners; (2) comprehension with the levels of comprehensibility for each item categorized on a 3-point scale (not comprehensible; moderately comprehensible; highly comprehensible). A minimum of three respondents selecting for each item of moderately or highly comprehensible were regarded as comprehensive; (3) test-retest reliability conducted with a 2-wk interval. The intraclass correlation coefficients (ICCs) and their 95%CIs were calculated using a two-way random effects model. Wilcoxon Signed Rank test for related samples was adopted to compare the medians of test-retest scores. An ICC value of 0.85 or higher together with P > 0.05, was considered acceptable; and (4) internal consistency of the total items was measured and evaluated by Cronbach's coefficient alpha (a). A Cronbach's a of 0.7 or higher was considered to represent good internal consistency. RESULTS: Eighteen @entity3 and 14 @entity2 presentation items were finalized from content validation. Five @entity0 with @entity1 ( @entity1 ) performed the comprehensibility and test-retest reliability tests. Comprehensibility score level of each presentation item was found to be moderate or high in three out of the five @entity0 . Test-retest reliability showed that the single measure ICC of the total @entity3 presentation items was 0.99 (95%CI: 0.89-0.99) and the median scores on the first and 14(th) days were 17 (IQR 6.5-27) and 21 (IQR 6-29) (P = 0.144) respectively. The single measure ICC of the total @entity2 presentation items was 0.88 (95%CI: 0.79-0.99) and the median scores on the first and 14(th) days were 10 (IQR 6-18) and 14 (IQR 7-23) (P = 0.144) respectively. The results of a descriptive correlation study on 140 survey @entity0 with @entity1 using the YY-AQ showed that internal consistency of the total @entity3 and @entity2 presentation items was satisfactory, with Cronbach's a of 0.79 and 0.78 respectively. CONCLUSION: The YY-AQ will be tested further for comprehensibility, test-retest and internal consistency reliabilities, scoring system validity, construct validity, convergent and discriminant validities, responsiveness and predictive validity.

title: Initial validation of the Yin-Yang Assessment Questionnaire for XXXX with @entity1 .

answer: @entity0


abstract: The study investigated the role of beliefs concerning @entity1 relief after treatment. Following the cognitive orientation theory, we hypothesized that beliefs concerning goals, norms, oneself, and general beliefs would predict the extent of improvement following acupuncture. Subjects were 30 Israeli @entity2 @entity0 (22 @entity0 , 8 @entity0 ; mean age 41.6 years). They were administered a questionnaire assessing the 4 belief types, and control measures assessing personality traits, demographic variables, and @entity1 characteristics. All underwent 4-6 acupuncture sessions. Improvement was determined by @entity0 and physician ratings, and an index based on medication, subjective evaluations, and duration of resting. There were two follow-ups. Three improvement groups were defined: none (n = 8), slight (n = 12), and high (n = 10). These groups did not differ on any of the variables tested except the 4 belief types. A discriminant analysis with belief types as predictors enabled correct classification of the @entity0 in 83% of the cases. A stepwise regression analysis showed that beliefs accounted for 85% of the variance. Discussion focuses on the nature of @entity1 relief and the role of beliefs in disease.

title: Cognitive orientation as predictor of XXXX relief following acupuncture.

answer: @entity1


abstract: Twenty-one @entity0 @entity3 biopsies were processed by mechanical and enzymatic methods to produce mixed cell suspensions. Cultures were prepared in small plastic flasks, and primary outgrowth occurred in 16/21 cultures. The period required for primary outgrowth ranged from 3 days to 14 days. We established serial propagation with 15/16 of the primary cultures. Sensitivity to @entity4 was determined between passages 3 to 12, using a microassay based on cell viability (uptake of a supravital stain, neutral red). Extracted dye was quantified in acidic- @entity2 using the MR580 Microelisa Autoreader (Dynatech). We observed a broad range of responsiveness to the drug among the 12 cell-strains tested. Thus, 4 cell strains were relatively sensitive; 4 were resistant to 10(4) IRU/ml of purified @entity4 . Four cell strains exhibited a level of responsiveness that was intermediate to that of these two groups. During propagation of these biopsies, cytopathology suggestive of @entity1 appeared in 4 of the cell-strains. This characteristic was not uniformly associated with high sensitivity to @entity0 beta interferon which is a very potent, naturally occurring antiviral substance. Our results support the concept that information concerning sensitivity to @entity4 and other cytostatic agents may be rapidly obtained using microcultures of @entity3 cultures in conjunction with supravital stain uptake studies. Additionally, these results suggest that further clinical studies with beta interferon should be undertaken to define the parameters which determine successful in vivo application.

title: @entity0 non-malignant and malignant XXXX derived cell cultures: proliferation and sensitivity to natural @entity0 fibroblast (beta) interferon.

answer: @entity3


abstract: Twenty-one @entity0 @entity3 biopsies were processed by mechanical and enzymatic methods to produce mixed cell suspensions. Cultures were prepared in small plastic flasks, and primary outgrowth occurred in 16/21 cultures. The period required for primary outgrowth ranged from 3 days to 14 days. We established serial propagation with 15/16 of the primary cultures. Sensitivity to @entity4 was determined between passages 3 to 12, using a microassay based on cell viability (uptake of a supravital stain, neutral red). Extracted dye was quantified in acidic- @entity2 using the MR580 Microelisa Autoreader (Dynatech). We observed a broad range of responsiveness to the drug among the 12 cell-strains tested. Thus, 4 cell strains were relatively sensitive; 4 were resistant to 10(4) IRU/ml of purified @entity4 . Four cell strains exhibited a level of responsiveness that was intermediate to that of these two groups. During propagation of these biopsies, cytopathology suggestive of @entity1 appeared in 4 of the cell-strains. This characteristic was not uniformly associated with high sensitivity to @entity0 beta interferon which is a very potent, naturally occurring antiviral substance. Our results support the concept that information concerning sensitivity to @entity4 and other cytostatic agents may be rapidly obtained using microcultures of @entity3 cultures in conjunction with supravital stain uptake studies. Additionally, these results suggest that further clinical studies with beta interferon should be undertaken to define the parameters which determine successful in vivo application.

title: XXXX non-malignant and malignant @entity3 derived cell cultures: proliferation and sensitivity to natural @entity0 fibroblast (beta) interferon.

answer: @entity0


abstract: Twenty-one @entity0 @entity3 biopsies were processed by mechanical and enzymatic methods to produce mixed cell suspensions. Cultures were prepared in small plastic flasks, and primary outgrowth occurred in 16/21 cultures. The period required for primary outgrowth ranged from 3 days to 14 days. We established serial propagation with 15/16 of the primary cultures. Sensitivity to @entity4 was determined between passages 3 to 12, using a microassay based on cell viability (uptake of a supravital stain, neutral red). Extracted dye was quantified in acidic- @entity2 using the MR580 Microelisa Autoreader (Dynatech). We observed a broad range of responsiveness to the drug among the 12 cell-strains tested. Thus, 4 cell strains were relatively sensitive; 4 were resistant to 10(4) IRU/ml of purified @entity4 . Four cell strains exhibited a level of responsiveness that was intermediate to that of these two groups. During propagation of these biopsies, cytopathology suggestive of @entity1 appeared in 4 of the cell-strains. This characteristic was not uniformly associated with high sensitivity to @entity0 beta interferon which is a very potent, naturally occurring antiviral substance. Our results support the concept that information concerning sensitivity to @entity4 and other cytostatic agents may be rapidly obtained using microcultures of @entity3 cultures in conjunction with supravital stain uptake studies. Additionally, these results suggest that further clinical studies with beta interferon should be undertaken to define the parameters which determine successful in vivo application.

title: @entity0 non-malignant and malignant @entity3 derived cell cultures: proliferation and sensitivity to natural XXXX fibroblast (beta) interferon.

answer: @entity0


abstract: @entity6 are uncommon @entity1 of the central nervous system. A series of 11 cases from the Vancouver General and British Columbia @entity0 's Hospitals, treated during the last 12 years, are reviewed. Some of the management problems commonly encountered with these @entity1 are discussed. Many of these @entity1 are associated with severe @entity4 at the time of diagnosis, and the perioperative management of this @entity4 remains a matter of some debate. The timing of and the necessity for shunting are major considerations. Large subdural fluid collections are often discovered in the postoperative period, and these occasionally cause symptoms of @entity3 . Reasons for this problem are suggested and possible steps for its prevention are proposed. The similarity between @entity2 and @entity5 has sometimes caused difficulty in pathological diagnosis. @entity7 , of which there were two in this series, also present a diagnostic challenge. Differential diagnosis affects the further treatment and prognosis for the @entity0 .

title: XXXX : problems in diagnosis and management.

answer: @entity6


abstract: OBJECTIVE: To explore the therapeutic effect of diagnosis and treatment program of integrative medicine (IM) on level 2 @entity1 in the young and middle-aged @entity0 and their ambulatory blood pressure. METHODS: A randomized, placebo parallel and controlled, multi-center clinical trial was performed. Totally 199 young and middle-aged level 2 @entity1 @entity0 were randomly assigned to the treatment group (99 cases) and the control group (100 cases). All received combined @entity2 treatment program by taking @entity3 Sustained Release Tablet and @entity4 as basic drugs. @entity0 in the treatment group additionally took Western medicine (WM) combined Jiangyabao serial drugs (0.31 g per tablet, 2 tablets each time, twice daily), while those in the control group additionally took WM combined simulative agents of Jiangyabao serial drugs (0.31 g per tablet, 2 tablets each time, twice daily). The treatment course was 8 weeks for all, and 24-week follow-ups performed. 24 h ambulatory blood pressure and casual blood pressure, and their efficacies were compared between the two groups, and safety assessed as well. RESULTS: Compared with before treatment in the same group, daytime and night casual blood pressure, as well as 24 h ambulatory blood pressure were all obviously improved in the two groups (P < 0.01). Average @entity2 at night decreased more in the treatment group than in the control group with statistical difference (P < 0.05). There was no statistical difference in total efficacies of daytime casual blood pressure or ambulatory blood pressure (P > 0.05). CONCLUSION: Jiangyabao serial drugs combined WM in treating young and middle-aged level 2 @entity1 @entity0 showed obvious effect in improving night blood pressure, especially for night diastolic blood pressure.

title: [Treatment of Level 2 XXXX by Diagnosis and Treatment Program of Integrative Medicine: a Multi-centre, Randomized Controlled Trial].

answer: @entity1


abstract: INTRODUCTION: Surgical clips inserted during breast-conserving surgery [BCS] serve as a surrogate of the lumpectomy cavity. Visualization of the surgical clips by imaging prior to radiotherapy (RT), during treatment planning, aids in designing the treatment volume for breast irradiation. OBJECTIVES: The aim of this study was to evaluate whether there is a distinct difference in the tendency to insert a metal clip during BCS, that is related to the hospital where the procedure was performed and to evaluate whether there are differences in the boost planning treatment volume ( @entity2 ). METHODS: This is a retrospective study. The records of all @entity0 treated by adjuvant RT after BCS were reviewed. Boost @entity2 was calculated in cubic centimeters (ccj and compared between the groups. RESULTS: Of the 143 @entity0 included in the study, 31% were operated on in private hospitals and 69% were operated on in public hospitals. A statistically significant difference was found in clip insertion in @entity0 treated in private hospitals compared to public hospitals. No statistical differences were found in the boost @entity2 size between the groups (p = 0.448). A similar difference was found when comparing tertiary public centers to smaller secondary public centers. CONCLUSION: Our study demonstrates a higher tendency to insert metal clips during BCS in private hospitals as compared to public hospitals. There were no differences in the @entity1 bed @entity2 in @entity0 with or without surgical clips.

title: [Placement of metal clips as a means for identifying the XXXX bed in @entity0 post lumpectomy].

answer: @entity1


abstract: INTRODUCTION: Surgical clips inserted during breast-conserving surgery [BCS] serve as a surrogate of the lumpectomy cavity. Visualization of the surgical clips by imaging prior to radiotherapy (RT), during treatment planning, aids in designing the treatment volume for breast irradiation. OBJECTIVES: The aim of this study was to evaluate whether there is a distinct difference in the tendency to insert a metal clip during BCS, that is related to the hospital where the procedure was performed and to evaluate whether there are differences in the boost planning treatment volume ( @entity2 ). METHODS: This is a retrospective study. The records of all @entity0 treated by adjuvant RT after BCS were reviewed. Boost @entity2 was calculated in cubic centimeters (ccj and compared between the groups. RESULTS: Of the 143 @entity0 included in the study, 31% were operated on in private hospitals and 69% were operated on in public hospitals. A statistically significant difference was found in clip insertion in @entity0 treated in private hospitals compared to public hospitals. No statistical differences were found in the boost @entity2 size between the groups (p = 0.448). A similar difference was found when comparing tertiary public centers to smaller secondary public centers. CONCLUSION: Our study demonstrates a higher tendency to insert metal clips during BCS in private hospitals as compared to public hospitals. There were no differences in the @entity1 bed @entity2 in @entity0 with or without surgical clips.

title: [Placement of metal clips as a means for identifying the @entity1 bed in XXXX post lumpectomy].

answer: @entity0


abstract: OBJECTIVE: To evaluate the effect of gonorrheal and @entity5 (GCC) on the risk of @entity4 ( @entity4 ) and @entity6 ( @entity6 ). STUDY DESIGN: A large cross-sectional sample of @entity0 (N = 1,120) was studied. Data on samples for GCC and pregnancy outcome were entered into a database from a retrospective chart review. RESULTS: There were 1,120 pregnancies with adequate data for analysis. Of those pregnancies 933 were unaffected by GCC, and 187 were affected. The rates of @entity4 were 17.79% and 16.58% for GCC-negative and GCC-positive pregnancies, respectively. @entity6 occurred in 3.97% and 2.67% of GCC-negative and GCC-positive pregnancies, respectively. @entity4 occurred in 8.25% and 8.02% of GCC-negative and GCC-positive pregnancies, respectively. No outcomes met statistical significance. When pregnancy outcomes were analyzed by trimester of infection, there was a higher risk of @entity4 but not @entity4 with @entity1 . This did meet statistical significance. There was a trend towards lower rate of cesarean section in the infected group of @entity0 , which did not meet statistical significance. CONCLUSION: @entity1 with @entity3 and/or @entity2 is not associated with @entity6 or @entity4 .

title: Screening for XXXX and Implications for Pregnancy Outcome. Are We Testing and Treating at the Right Time?

answer: @entity3


abstract: BACKGROUND: Perinatal @entity1 (PND) affects approximately 10-15% of @entity0 , worldwide. PND screening, using screening tools, has been undertaken by a broad range of healthcare professionals in different settings. Our objective was to explore the acceptability of PND screening and how acceptability was being assessed. METHODS: A systematic literature review of studies that explored the acceptability of PND screening was carried out throughout MEDLINE, PsycINFO, PubMed, CINAHL, Embase, Maternity and @entity0 Care and Joanna Briggs Institute databases. RESULTS: Twenty-eight out of twenty-nine publications reported PND screening to be acceptable to most @entity0 . A wide range of terms, questions and statements was used to infer, assess or report on acceptability. There was no uniform, psychometrically tested tool used to measure acceptability across the studies. LIMITATIONS: Broad inclusion criteria and methodological differences limited comparisons, but are overcome by the comprehensiveness of the data and the lack of uniformity across studies. CONCLUSIONS: Even though PND screening appears acceptable, it is difficult to draw conclusions about PND screening acceptability as studies used different methods to infer, assess or report on acceptability. The lack of a uniform, psychometrically tested tool to measure acceptability is not unique to PND. Nonetheless, the majority of perinatal @entity0 and healthcare professionals reported positive attitudes towards PND screening using different tools in different settings, indicating that it may be the responsibility of all healthcare professionals who come into contact with perinatal @entity0 .

title: A systematic review on the acceptability of perinatal XXXX screening.

answer: @entity1


abstract: PURPOSE: To evaluates the role of measuring intraocular pressure (IOP) outside office-hour in primary adult onset @entity1 . METHODS: This retrospective study included 100 cases of primary adult onset @entity1 . IOP readings obtained with Goldmann applanation tonometry between 7 am and 10 pm were compared to office-hour readings. RESULTS: One hundred @entity0 were enrolled (mean age: 58.64  10.98 years) in the study. Overall, mean diurnal IOP was significantly higher than mean office IOP (p<0.05). Two-thirds of the @entity0 had peak IOP measurements outside office-hour. Mean diurnal IOP fluctuation (7.03  2.69mm Hg) was significantly higher than mean office IOP fluctuation (4.31  2.6mm Hg) (p<0.003). There was a significant correlation between baseline IOP and fluctuation in IOP (r=0.61, p<0.001). CONCLUSION: The mean diurnal IOP and IOP fluctuations were higher than office-hour readings in @entity0 with primary adult onset @entity1 . Diurnal monitoring may be particularly useful in @entity0 with high baseline IOP.

title: Diurnal versus office-hour intraocular pressure fluctuation in primary adult onset XXXX .

answer: @entity1


abstract: One hundred fifty-six @entity0 underwent investigation and operation for @entity3 : 145 had attempts at curative operations and 11 had His bundle section. Operative mortality was 0.68% and there were no late @entity1 among @entity0 having curative operations. One @entity0 died suddenly 1 year after His bundle section. All @entity0 underwent electrophysiologic study before discharge and 6 months postoperatively. A satisfactory result, without @entity3 and without medication, was achieved in 96.5% of all @entity0 . Ninety-three percent have no @entity3 and no demonstrable reentrant pathway at electrophysiologic study. All free wall accessory atrioventricular connections were divided and 97.7% of the @entity0 were cured. Ninety percent of @entity0 with posterior septal accessory atrioventricular connections had a satisfactory result, with cure demonstrated at late electrophysiologic study in 84%. Fifteen @entity0 with atrioventricular junctional reentrant @entity2 were all cured, with preservation of normal atrioventricular conduction. Eight (88%) of nine @entity0 with right @entity2 were cured, and two @entity0 with nodoventricular fibers and one @entity0 with incessant @entity2 had satisfactory results. @entity3 is now a potentially curable disorder when managed by low risk surgical procedures that offer a high cure rate.

title: Surgical therapy for XXXX , a potentially curable disorder.

answer: @entity3


abstract: Classical @entity2 was repaired by a transatrial-transpulmonary approach in 61 of 70 @entity0 treated surgically on one surgical service between July 1981 and December 1985. Their ages ranged from 2.5 months to 57 years (mean 52.9 +/- 104.2 months). The @entity5 was closed through the right atrium and tricuspid valve in 60 @entity0 and via the pulmonary artery in one @entity0 with a @entity1 . @entity3 was made in 38 @entity0 to expose the stenotic pulmonary valve for valvotomy and to begin the infundibular mobilization and resection. It was extended through a small pulmonary anulus primarily in 15 @entity0 and secondarily in one, a minimal distance upon the right ventricular infundibulum to enlarge the outflow tract to 2 standard deviations larger than the mean normal pulmonary valve anulus diameter. There were no hospital or late deaths or reoperations among the entire group. The mean postrepair peak right ventricular/left ventricular pressure measured in the operating room was 0.52 +/- 0.165 for the entire group of 61 @entity0 which indicates similar relief of @entity4 to that obtained by the classical transventricular repair. At follow-up between 2.3 and 53.8 months (mean 22.6) each @entity0 was in New York Heart Association Class I and without cardiac medication. Postoperative cardiac catheterization studies performed in nine @entity0 between 4 and 28 months after operation showed no residual @entity5 and a mean peak right/left ventricular pressure of 0.42 +/- 0.13. This series indicates that successful repair of @entity2 can be accomplished in most @entity0 by a transatrial-transpulmonary approach, which may provide improved right ventricular function over the long term.

title: Transatrial-transpulmonary repair of XXXX .

answer: @entity2


abstract: Reports on the effect of @entity0 age on the prognosis for @entity3 vary. We have tested the effect of aging using a model of @entity2 @entity3 in groups of @entity2 of different ages. In experiment A, Balb/c @entity2 of age groups 3-4 weeks, 10-12 weeks, 24-32 weeks and 40-48 weeks (13 @entity2 /group) were injected with 5 X 10(4) MC-26 cells subcutaneously in the right flank. @entity1 were measured twice weekly, and the rate of occurrence of @entity1 , mortality rate, and growth rate were calculated. In experiment B, the same plan as experiment A was used, except @entity2 of age groups I (14 days), II (3-4 weeks), and III (20-22 months) were used with @entity1 doses of 1 X 10(4) cells and 5 X 10(5) cells (9-15 @entity2 /group). In both experiments, the rate of growth of @entity1 , mortality rate, and sizes of @entity1 obtained were the same. In experiment A, the rate of occurrence of the @entity1 was the same in all groups, but in experiment B the occurrence of the @entity1 varied. A palpable @entity1 appeared earliest in the weanling @entity2 (14 days), next in old @entity2 (20-22 months), and last in the young adult group (3-4 weeks). @entity1 doubling time was longest in the young adult @entity2 (7 days), intermediate in the old @entity2 (6.1 days), and shortest in the weanling @entity2 (5.5 days). Established @entity1 grew at similar rates (as assessed by doubling time), independent of host age. Mortality rates were similar.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The effect of aging on the growth of XXXX .

answer: @entity3


abstract: @entity2 is a major cause of maternal and fetal morbidity and mortality, and this risk is highest in the areas of unstable @entity2 transmission. In 1990 and 1991 the Department of Obstetrics and Gynecology of Sir Sayajirao General Hospital in central Gujarat, India, has cared for a total of 445 urban as well as rural @entity0 with @entity2 in pregnancy: 232 were labor ward admissions and 213 were antenatal ward admissions. @entity6 infection affected 97.27% of @entity0 , both primigravidae and multigravidae. Heavy @entity8 was observed in 27.14% of primigravidae and 48.57% in secundigravidae, however, this was not statistically significant. Out of the 260 (58.42.) cases who had various degrees of @entity3 , 59 (22.69) had severe @entity3 with haemoglobin of less than 6.0 gm O/dl. Within this group, 71.16% @entity0 were primigravidae or secundigravidae, the rest were multigravidae. Out of the 6 @entity0 in first trimester, the miscarriage rate was 100%. In the second trimester, out of 52 @entity0 74.99 pregnancies were discontinued, whereas in the third trimester, the miscarriage rate was 18.17%. This observation was statistically significant (p 0.05). 178 @entity0 who were admitted antenatally were discharged, their pregnancy outcome was not known, and accordingly they were excluded. There were 11 @entity0 in the first trimester, 139 in the second trimester, and 295 in the third trimester. The known pregnancy losses were 54.54% in the first trimester. 28.05% in the second trimester, and 12.88% in the third trimester. 75.59% of those with minor @entity8 and 47.36% with heavy @entity8 had a normal pregnancy outcome. The overall fetal loss was 31.08%, which was almost twice that of the miscarriage rates among the general population. @entity1 attributed to @entity2 in pregnancy were 15, with @entity9 accounting for 5 @entity1 . 46.66% of the @entity1 occurred in primigravidae and secundigravidae. The other causes of mortality were postpartum @entity4 , @entity5 , and @entity7 .

title: Maternal manifestations of XXXX in pregnancy: a review.

answer: @entity2


abstract: We describe herein the case of an adolescent @entity0 with @entity3 non-responsive to oral @entity2 , associated with low-grade fever, diminished appetite and fatigue. A palpable mass below the xiphoid was noted. Laboratory findings were consistent with @entity3 of @entity1 . Direct antiglobulin test was positive without any other evidence of @entity6 . Other autoantibodies, such as anti-thyroid and anti-nuclear antibodies, were also positive. After thorough investigation, @entity7 was the most likely diagnosis on the basis of high serum @entity5 and the magnetic resonance imaging findings. @entity4 positron emission tomography-computed tomography showed a localized hypermetabolic mass, which was resected. @entity7 of plasma type was identified on histology. Hemogloblin and @entity5 gradually returned to normal, whereas positive autoantibodies became negative. This case emphasizes the need to investigate thoroughly for the underlying cause of @entity3 of @entity1 and to include @entity7 in the differential diagnosis, on the measurement of @entity5 .

title: @entity3 and autoimmunity markers in an adolescent with XXXX .

answer: @entity7


abstract: We describe herein the case of an adolescent @entity0 with @entity3 non-responsive to oral @entity2 , associated with low-grade fever, diminished appetite and fatigue. A palpable mass below the xiphoid was noted. Laboratory findings were consistent with @entity3 of @entity1 . Direct antiglobulin test was positive without any other evidence of @entity6 . Other autoantibodies, such as anti-thyroid and anti-nuclear antibodies, were also positive. After thorough investigation, @entity7 was the most likely diagnosis on the basis of high serum @entity5 and the magnetic resonance imaging findings. @entity4 positron emission tomography-computed tomography showed a localized hypermetabolic mass, which was resected. @entity7 of plasma type was identified on histology. Hemogloblin and @entity5 gradually returned to normal, whereas positive autoantibodies became negative. This case emphasizes the need to investigate thoroughly for the underlying cause of @entity3 of @entity1 and to include @entity7 in the differential diagnosis, on the measurement of @entity5 .

title: XXXX and autoimmunity markers in an adolescent with @entity7 .

answer: @entity3


abstract: OBJECTIVE: @entity7 ( @entity7 ) is caused by a mutation within the @entity6 gene or upstream of the @entity6 complex locus. It is characterized by target organ resistance to PTH, resulting in hypocalcaemia and hyperphosphataemia. Studies in @entity0 with @entity7 are limited. We sought to identify all @entity0 in Denmark with @entity7 and access their mortality data and risk of complications. DESIGN: @entity0 were identified through the Danish National @entity0 Registry and a prescription database, with subsequent validation by investigation of @entity0 charts. METHODS: For each case, three age- (  2 years) and gender-matched controls were randomly selected from the general background population. We identified a total of 60 cases, equal to a prevalence of 1  1/100 000 inhabitants. The average age at diagnosis was 13 years (range 1-62 years), and 42 were @entity0 . Only 14 @entity0 had an identified mutation in the @entity6 gene. RESULTS: Compared with controls, @entity0 with @entity7 had an increased risk of @entity1 (P < 0  01), @entity4 (P < 0  01), @entity5 (P < 0  01) and @entity3 (P < 0  01), whereas their risk of renal, cardiovascular, malignant disorders and @entity2 was compatible with the general background population. The same tendencies were found in a subgroup analysis in cases with genetically verified @entity7 . CONCLUSION: @entity0 with @entity7 have an increased risk of @entity1 , @entity4 , @entity3 and @entity5 , whereas mortality among @entity7 @entity0 is compatible with that in the background population.

title: XXXX - epidemiology, mortality and risk of complications.

answer: @entity7


abstract: AIMS: @entity3 ( @entity3 ) and @entity2 ( @entity2 ) subtypes of @entity1 ( @entity1 ) show different clinical manifestations; however, their underlying neural substrates remain incompletely understood. This study aimed at investigating the subtype-specific patterns of spontaneous brain activity in @entity1 . METHODS: Thirty-one @entity0 with @entity1 (12 @entity2 /19 @entity3 ) and 22 healthy gender- and age-matched controls were recruited. Resting-state functional magnetic resonance imaging data were collected, and @entity5 ( @entity5 ) was measured. Voxelwise one-way analysis of covariance and post hoc analyses of @entity5 were performed among the three groups, with age and gender as covariates ( @entity4 daily dosage and gray matter volume as additional covariates for validation analysis). Correlations of clinical variables (e.g., disease duration and @entity3 / @entity2 subscale score) with @entity5 values were examined. RESULTS: Compared with controls, @entity0 with @entity2 exhibited higher @entity5 in the right cerebellar posterior lobe and @entity0 with @entity3 exhibited lower @entity5 in the bilateral putamen and cerebellar posterior lobe, and higher values primarily in several cortical areas including the inferior and superior temporal gyrus, superior frontal, and parietal gyrus. Compared with @entity0 with @entity3 , @entity0 with @entity2 had higher @entity5 in the bilateral putamen and the cerebellar posterior lobe, as well as lower @entity5 in the bilateral temporal gyrus and the left superior parietal lobule. In all @entity0 , @entity5 in the bilateral cerebellar posterior lobe positively correlated with @entity2 score and @entity5 in the bilateral putamen negatively correlated with @entity3 score. CONCLUSION: Different patterns of spontaneous neural activity in the cerebellum and putamen may underlie the neural substrate of @entity1 motor subtypes.

title: Different patterns of spontaneous brain activity between XXXX and postural instability/gait difficulty subtypes of @entity1 : a resting-state fMRI study.

answer: @entity2


abstract: AIMS: @entity3 ( @entity3 ) and @entity2 ( @entity2 ) subtypes of @entity1 ( @entity1 ) show different clinical manifestations; however, their underlying neural substrates remain incompletely understood. This study aimed at investigating the subtype-specific patterns of spontaneous brain activity in @entity1 . METHODS: Thirty-one @entity0 with @entity1 (12 @entity2 /19 @entity3 ) and 22 healthy gender- and age-matched controls were recruited. Resting-state functional magnetic resonance imaging data were collected, and @entity5 ( @entity5 ) was measured. Voxelwise one-way analysis of covariance and post hoc analyses of @entity5 were performed among the three groups, with age and gender as covariates ( @entity4 daily dosage and gray matter volume as additional covariates for validation analysis). Correlations of clinical variables (e.g., disease duration and @entity3 / @entity2 subscale score) with @entity5 values were examined. RESULTS: Compared with controls, @entity0 with @entity2 exhibited higher @entity5 in the right cerebellar posterior lobe and @entity0 with @entity3 exhibited lower @entity5 in the bilateral putamen and cerebellar posterior lobe, and higher values primarily in several cortical areas including the inferior and superior temporal gyrus, superior frontal, and parietal gyrus. Compared with @entity0 with @entity3 , @entity0 with @entity2 had higher @entity5 in the bilateral putamen and the cerebellar posterior lobe, as well as lower @entity5 in the bilateral temporal gyrus and the left superior parietal lobule. In all @entity0 , @entity5 in the bilateral cerebellar posterior lobe positively correlated with @entity2 score and @entity5 in the bilateral putamen negatively correlated with @entity3 score. CONCLUSION: Different patterns of spontaneous neural activity in the cerebellum and putamen may underlie the neural substrate of @entity1 motor subtypes.

title: Different patterns of spontaneous brain activity between @entity2 and postural instability/gait difficulty subtypes of XXXX : a resting-state fMRI study.

answer: @entity1


abstract: Based on current health surveys in South Africa, the @entity1 and @entity2 epidemic there is spreading faster than health workers can develop a policy to combat it. 120 million male and 90,000 female condoms have been distributed to the areas that are most affected. According to Health Minister Nkosazana Zuma, the percentage of @entity1 -positive pregnant @entity0 in the North-West Province rose from 8.3% in 1995 to 25% in 1997. In June 1996, 1.7 million @entity0 were at risk; this number rose to 2.5 million in 1997, 90,000 of whom will develop advanced @entity2 by the end of the year. According to independent researchers, 800 @entity0 are infected daily, which means that 16% of South Africa's workers are already infected. This figure could rise to 20% by the year 2000 according to Professor Ronald Green-Thompson. At that time, the cost to the South African economy would be between @entity3 25 million and @entity3 2.3 billion. The World Health Organization (WHO) is touring provinces for the first time to select sites for use by assessment teams in July. Dr. Liz Floyd, head of the @entity1 / @entity2 and communicable diseases unit, states that, although @entity3 6.1 million ( @entity3 2.3 million more than in 1996) have been designated to fight the epidemic, new measures have to be found to avoid an infection rate of 1 in 5 young @entity0 by the end of the year. The unit conducts annual surveys among @entity0 attending public prenatal clinics. Infection appears to be linked to poverty, migration, family breakdowns, and prostitution. The greatest increase has been among @entity0 aged 20-24 years. According to Floyd, "the supply of condoms is still uneven and unreliable, especially in high density peri-urban settlements and shanty towns. Primary care for the youth and home-based schemes are poorly coordinated and erratic." Zuma believes that schools should be targeted; she hopes to educate @entity0 in 7400 secondary and 13,500 primary schools. Donor agencies, churches, workers, and business @entity0 have become involved, including Archbishop Desmond Tutu and President Nelson Mandela, who are appearing on radio and television to promote condom use.

title: XXXX epidemic runs riot in South Africa.

answer: @entity2


abstract: UNASSIGNED: OBJECT The incidence and risk factors of @entity3 on MR diffusion-weighted imaging (DWI) were analyzed after the endovascular coiling of @entity5 ( @entity5 ). METHODS Data obtained from 271 consecutive @entity0 (70 @entity0 and 201 @entity0 ; median age 57 years; range 23-79 years) who presented with UIA for coil embolization between July 2011 and June 2013 were analyzed. Two independent reviewers examined the DWI and apparent diffusion coefficient maps obtained the following day for the presence of restrictive diffusion spots and counted the number of spots. Multivariate analysis was then performed to identify independent risk factors for developing microembolism following the coiling of an @entity6 . RESULTS @entity3 were noted in 101 of 271 @entity0 (37.3%). The results of the multivariate analysis showed that the following factors significantly influenced the risk for microembolism: age, @entity1 , previous history of @entity4 , high-signal FLAIR lesions in the white matter, @entity6 , and the insertion of an Enterprise stent (all ORs > 1.0 and all p values < 0.05). Previously known risk factors such as prolonged procedure duration, @entity6 size, and decreased antiplatelet function did not show any significant influence. CONCLUSIONS The incidence of microembolism after endovascular coiling of UIA was not low. Lesions occurred more frequently in @entity0 with vascular status associated with old age, @entity1 , and previous @entity2 . @entity6 multiplicity and the type of stent used for treatment also influenced lesion occurrence.

title: Microembolism after endovascular coiling of XXXX : incidence and risk factors.

answer: @entity5


abstract: UNASSIGNED: We present a case of @entity9 and dissection (FTAAD) in a pregnant female. FTAAD is an @entity1 resulting from several genetic mutations critical to aortic wall integrity have been identified. One such mutation is the myosin heavy chain gene ( @entity11 ) which is responsible for 1-2% of all FTAAD cases. This mutation results in aortic @entity4 , loss of @entity10 , and reticulin fiber fragmentation predisposing to TAAD. @entity8 is more aggressive during pregnancy as a result of increased wall stress from hyperdynamic cardiovascular changes and @entity2 -induced aortic media degeneration. Our @entity0 was a 29-year-old G2P1 @entity0 at 26  weeks gestation presenting with @entity5 . Work-up revealed a 6.4-cm ascending aortic @entity3 with a type A dissection extending into all arch vessels, @entity6 at the isthmus, and a separate focal type B @entity7 with visceral involvement. Surgical management included concomitant cesarean section with delivery of a live premature @entity0 , tubal ligation, ascending aortic replacement with reconstruction of the arch vessels, and aortic valve resuspension. The type B dissection was managed medically without complication. This is the first reported case of @entity7 in a @entity0 with FTAAD/ @entity11 mutation and pregnancy. This case highlights that FTAAD and pregnancy cause @entity4 via distinct mechanisms and that hyperdynamics of pregnancy increase aortic wall stress. Management of pregnancy associated with aortopathy requires early transfer to a tertiary center, careful investigation to identify familial aortopathy, fetal monitoring, and a multidisciplinary team approach.

title: Genetics, Pregnancy, and XXXX .

answer: @entity4


abstract: Higher levels of parental knowledge about youth activities have been associated with lower levels of youth risky behavior. Yet little is known about how parental knowledge fluctuates during early adolescence and how those @entity4 are associated with the development of @entity1 . We use the term lability to describe within- @entity0 @entity4 in knowledge over time with higher lability indicating greater @entity4 in knowledge from year-to-year. This longitudinal study of rural adolescents (N   =   840) investigated if change in parental knowledge across four waves of data from grades 6 to 8 is characterized by lability, and if greater lability is associated with higher youth substance use, delinquency, and internalizing problems in grade 9. Our models indicated that only some of the variance in parental knowledge was accounted for by developmental trends. The remaining residual variance reflects within- @entity0 @entity4 around these trends, lability, and measurement and occasion-specific error. Even controlling for level and developmental trends in knowledge, higher knowledge lability (i.e., more fluctuation) was associated with increased risk for later @entity2 and @entity3 use, and for @entity0 , higher delinquency and internalizing problems. Our findings suggest that lability in parental knowledge has unique implications for adolescent outcomes. The discussion focuses on mechanisms that may link knowledge lability to substance use. Interventions may be most effective if they teach parents to consistently and predictably decrease knowledge across early adolescence.

title: Knowledge Lability: Within- XXXX Changes in Parental Knowledge and Their Associations with Adolescent Problem Behavior.

answer: @entity0


abstract: BACKGROUND AND PURPOSE: CXC chemokine ligand 13 and @entity3 have emerged as CSF biomarkers for the diagnosis of @entity4 . Our hypothesis is that the combined use of ADC, @entity3 will result in increased diagnostic performance compared with the use of ADC values alone. MATERIALS AND METHODS: Eighty-seven @entity0 were included in this study, including 43 with @entity4 and 44 without @entity4 (21 metastases, 14 high-grade @entity2 , 9 tumefactive demyelinating lesions) who had undergone CSF proteomic analysis and had a new enhancing mass on brain MR imaging. Average ADC was derived by contouring the contrast-enhancing @entity1 volume. Group means were compared via t tests for average ADC, @entity3 . Receiver operating characteristic analysis was performed for each individual variable. Multiple-variable logistic regression with receiver operating characteristic analysis was performed, and the multiple-variable receiver operating characteristic was compared with single-variable receiver operating characteristics. RESULTS: The average ADC was lower and CSF CXC chemokine ligand 13 and @entity3 values were higher in @entity4 (P < .001). Areas under the curve ranged from 0.739 to 0.832 for single-variable ROC. Multiple-variable logistic regression yielded statistically significant individual effects for all 3 variables in a combined model. Multiple-variable receiver operating characteristics (area under the curve, 0.928) demonstrated statistically significantly superior diagnostic performance compared with the use of single variables alone. CONCLUSIONS: The combined use of ADC, CSF @entity3 results in increased diagnostic performance for the diagnosis of @entity4 . This finding highlights the importance of CSF analysis when the diagnosis of @entity4 is considered on the basis of MR imaging.

title: The Combined Performance of ADC, CSF CXC Chemokine Ligand 13, and CSF XXXX in the Diagnosis of Central Nervous System Lymphoma.

answer: @entity3


abstract: BACKGROUND: New methods have been introduced to facilitate dental procedures, but the administration of local anesthesia is still necessary to perform @entity1 control during several dental procedures. AIM: To evaluate the effectiveness of the @entity3 Denti-patch    system versus the @entity3 topical anesthetic gel in @entity0 concerning @entity1 reaction during injection. MATERIALS AND METHODS: One hundred 9-12-year-old cooperative @entity0 weighing more than 29 kg in need of bilateral dental treatment requiring maxillary and mandibular injection and not suffering from acute @entity1 as a result of pulpits on the day of treatment were selected. The @entity0 were then divided into two groups: Group 1 comprising of 50 @entity0 in need of bilateral maxillary treatment and Group 2 compromising of 50 @entity0 requiring bilateral mandibular treatment. These groups were further subdivided into subgroups A and B; those receiving Denti-patch    on one side and @entity3 gel on the contralateral side, respectively. @entity1 or comfort was evaluated during injection using @entity2 ( @entity2 ) scale (objective method) while, using @entity1 ( @entity1 ) scale (subjective method) after injection by a trained assistant blinded to the procedure. STATISTICAL ANALYSIS USED: Comparison of the results was performed using Mann-Whitney U-test and Wilcoxon signed-ranks test for @entity2 and @entity1 score. RESULT: There was a statistically significant difference between the patch and the gel group for maxilla (P < 0.0001), as well as mandible (P = 0.01) with respect to @entity2 score given by the @entity0 . Similarly, with @entity1 scale, there was a statistically significant difference between the patch and the gel groups in both maxilla and mandible (P < 0.0001). However, there was no statistical difference between the patch Groups 1A and IIA or the gel Groups 1B and II B. CONCLUSION: The Denti-patch    system can significantly reduce the needle injection @entity1 more than the gel.

title: Effectiveness of XXXX Denti patch (  ) system versus @entity3 gel as topical anesthetic agent in @entity0 .

answer: @entity3


abstract: BACKGROUND: New methods have been introduced to facilitate dental procedures, but the administration of local anesthesia is still necessary to perform @entity1 control during several dental procedures. AIM: To evaluate the effectiveness of the @entity3 Denti-patch    system versus the @entity3 topical anesthetic gel in @entity0 concerning @entity1 reaction during injection. MATERIALS AND METHODS: One hundred 9-12-year-old cooperative @entity0 weighing more than 29 kg in need of bilateral dental treatment requiring maxillary and mandibular injection and not suffering from acute @entity1 as a result of pulpits on the day of treatment were selected. The @entity0 were then divided into two groups: Group 1 comprising of 50 @entity0 in need of bilateral maxillary treatment and Group 2 compromising of 50 @entity0 requiring bilateral mandibular treatment. These groups were further subdivided into subgroups A and B; those receiving Denti-patch    on one side and @entity3 gel on the contralateral side, respectively. @entity1 or comfort was evaluated during injection using @entity2 ( @entity2 ) scale (objective method) while, using @entity1 ( @entity1 ) scale (subjective method) after injection by a trained assistant blinded to the procedure. STATISTICAL ANALYSIS USED: Comparison of the results was performed using Mann-Whitney U-test and Wilcoxon signed-ranks test for @entity2 and @entity1 score. RESULT: There was a statistically significant difference between the patch and the gel group for maxilla (P < 0.0001), as well as mandible (P = 0.01) with respect to @entity2 score given by the @entity0 . Similarly, with @entity1 scale, there was a statistically significant difference between the patch and the gel groups in both maxilla and mandible (P < 0.0001). However, there was no statistical difference between the patch Groups 1A and IIA or the gel Groups 1B and II B. CONCLUSION: The Denti-patch    system can significantly reduce the needle injection @entity1 more than the gel.

title: Effectiveness of @entity3 Denti patch (  ) system versus XXXX gel as topical anesthetic agent in @entity0 .

answer: @entity3


abstract: BACKGROUND: New methods have been introduced to facilitate dental procedures, but the administration of local anesthesia is still necessary to perform @entity1 control during several dental procedures. AIM: To evaluate the effectiveness of the @entity3 Denti-patch    system versus the @entity3 topical anesthetic gel in @entity0 concerning @entity1 reaction during injection. MATERIALS AND METHODS: One hundred 9-12-year-old cooperative @entity0 weighing more than 29 kg in need of bilateral dental treatment requiring maxillary and mandibular injection and not suffering from acute @entity1 as a result of pulpits on the day of treatment were selected. The @entity0 were then divided into two groups: Group 1 comprising of 50 @entity0 in need of bilateral maxillary treatment and Group 2 compromising of 50 @entity0 requiring bilateral mandibular treatment. These groups were further subdivided into subgroups A and B; those receiving Denti-patch    on one side and @entity3 gel on the contralateral side, respectively. @entity1 or comfort was evaluated during injection using @entity2 ( @entity2 ) scale (objective method) while, using @entity1 ( @entity1 ) scale (subjective method) after injection by a trained assistant blinded to the procedure. STATISTICAL ANALYSIS USED: Comparison of the results was performed using Mann-Whitney U-test and Wilcoxon signed-ranks test for @entity2 and @entity1 score. RESULT: There was a statistically significant difference between the patch and the gel group for maxilla (P < 0.0001), as well as mandible (P = 0.01) with respect to @entity2 score given by the @entity0 . Similarly, with @entity1 scale, there was a statistically significant difference between the patch and the gel groups in both maxilla and mandible (P < 0.0001). However, there was no statistical difference between the patch Groups 1A and IIA or the gel Groups 1B and II B. CONCLUSION: The Denti-patch    system can significantly reduce the needle injection @entity1 more than the gel.

title: Effectiveness of @entity3 Denti patch (  ) system versus @entity3 gel as topical anesthetic agent in XXXX .

answer: @entity0


abstract: BACKGROUND: @entity3 are uncommon, and controversies exist regarding their management. The objective of this study was to evaluate the outcomes of a relatively large cohort of @entity0 with @entity3 treated with minimally invasive surgical techniques. METHODS: We conducted a retrospective review of @entity0 who underwent minimally invasive surgical treatment for symptomatic esophageal diverticula during a 15-year period. The primary end point was 30-day mortality. In addition, we evaluated the morbidity, improvement in @entity1 (score: 1, best to 5, worst), and quality of life (Gastroesophageal Reflux Disease-Health-Related Quality of Life score: 0, best to 50, most symptoms). RESULTS: Fifty-seven @entity0 underwent minimally invasive surgical treatment of symptomatic @entity3 . The most common symptom was @entity1 (45 of 57; 79%). A @entity2 or distal mechanical obstruction was identified in 49 @entity0 (86%). Approaches used included video-assisted thoracoscopic surgery (n = 33), laparoscopy (n = 18), and combined video-assisted thoracoscopic surgery and laparoscopy (n = 6). The most common procedure performed was diverticulectomy and myotomy (47 of 57 @entity0 ; 82.5%). The 30-day mortality was 0%. There were 4 @entity0 (7%) with postoperative leaks requiring reoperation. During follow-up, the median @entity1 score improved from 3 to 1 (p < 0.001). The median Gastroesophageal Reflux Disease-Health-Related Quality of Life score after surgery was 5 (excellent). CONCLUSIONS: A minimally invasive surgical approach for the management of @entity3 is safe and effective during intermediate-term follow-up when performed by surgeons experienced in esophageal surgery and minimally invasive techniques. Further follow-up is required to assess the durability of these results. The optimal approach and procedures performed should be determined on an individualized basis after a thorough investigation.

title: XXXX : A 15-Year Experience of Minimally Invasive Surgical Management.

answer: @entity3


abstract: OBJECTIVE: Red cell distribution width (RDW) is a measure of variation in the size of circulating red blood cells. Recent studies have reported a strong independent relation between elevated RDW and short- and long-term prognosis in @entity2 . The aim of the present study was to investigate the relationship between admission RDW-to-platelet ratio (RPR) and in-hospital and long-term prognosis in @entity0 with @entity3 ( @entity3 ) undergoing primary percutaneous coronary intervention (PCI). METHODS: A total of 470 consecutive @entity0 with a diagnosis of @entity3 who underwent primary PCI were included in this prospective study. The @entity0 were divided into two groups based on their admission RPR: high (>0.061) RPR group and low ( <=0.061) RPR group. The @entity0 were followed for adverse clinical outcomes in-hospital and for up to one year after discharge. RESULTS: In-hospital @entity1 , major adverse cardiovascular events (MACE), advanced @entity4 and @entity5 were significantly higher in the high RPR group (p<0.05). All-cause and @entity1 , MACE, fatal reinfarction, advanced @entity4 , and rehospitalization for cardiac cause were more frequent in the high RPR group in one-year follow-up (p<0.05). High RPR was found to be a significant independent predictor of one-year @entity1 in multivariate analysis (p=0.003, OR: 3.106, 95% CI: 1.456-6.623). CONCLUSION: RPR is an inexpensive and readily available biomarker that provides an additional level of risk stratification beyond that provided by conventional risk parameters in predicting long-term MACE and @entity1 in @entity3 .

title: The prognostic value of admission red cell distribution width-to-platelet ratio in @entity0 with XXXX undergoing primary percutaneous coronary intervention.

answer: @entity3


abstract: OBJECTIVE: Red cell distribution width (RDW) is a measure of variation in the size of circulating red blood cells. Recent studies have reported a strong independent relation between elevated RDW and short- and long-term prognosis in @entity2 . The aim of the present study was to investigate the relationship between admission RDW-to-platelet ratio (RPR) and in-hospital and long-term prognosis in @entity0 with @entity3 ( @entity3 ) undergoing primary percutaneous coronary intervention (PCI). METHODS: A total of 470 consecutive @entity0 with a diagnosis of @entity3 who underwent primary PCI were included in this prospective study. The @entity0 were divided into two groups based on their admission RPR: high (>0.061) RPR group and low ( <=0.061) RPR group. The @entity0 were followed for adverse clinical outcomes in-hospital and for up to one year after discharge. RESULTS: In-hospital @entity1 , major adverse cardiovascular events (MACE), advanced @entity4 and @entity5 were significantly higher in the high RPR group (p<0.05). All-cause and @entity1 , MACE, fatal reinfarction, advanced @entity4 , and rehospitalization for cardiac cause were more frequent in the high RPR group in one-year follow-up (p<0.05). High RPR was found to be a significant independent predictor of one-year @entity1 in multivariate analysis (p=0.003, OR: 3.106, 95% CI: 1.456-6.623). CONCLUSION: RPR is an inexpensive and readily available biomarker that provides an additional level of risk stratification beyond that provided by conventional risk parameters in predicting long-term MACE and @entity1 in @entity3 .

title: The prognostic value of admission red cell distribution width-to-platelet ratio in XXXX with @entity3 undergoing primary percutaneous coronary intervention.

answer: @entity0


abstract: BACKGROUND: @entity0 with " @entity2 " ( @entity2 ) unsuitable for coronary revascularization experience high levels of hospitalization and poor health-related quality of life. Randomized trials have shown @entity1 ( @entity1 ) to be a promising treatment for @entity3 and @entity2 ; however, none has compared @entity1 with usual care (UC). The aim of this pilot study was to address the key uncertainties of conducting a definitive multicenter trial to assess the clinical and cost-effectiveness of @entity1 in @entity2 @entity0 , i.e., recruitment and retention of @entity0 , burden of outcome measures, our ability to standardize UC in a UK @entity4 setting. METHODS: @entity2 @entity0 deemed suitable were randomized in a 1:1 ratio to @entity1 plus UC ( @entity1 group) or UC alone (UC group). We sought to assess: recruitment, uptake, and retention of @entity0 ; feasibility and acceptability of @entity1 treatment; the feasibility and acceptability of standardizing UC; and the feasibility and acceptability of the proposed trial outcome measures. @entity0 outcomes were assessed at baseline (prerandomization) and three and six months postrandomization. RESULTS: We failed to meet our planned recruitment target (45 @entity0 ) and randomized 29 @entity0 (15 @entity1 group, 14 UC group) over a 42-month period across four sites. None of the study @entity0 chose to withdraw following consent and randomization. With exception of two deaths, all completed evaluation at baseline and follow-up. Although the study was not formally powered to compare outcomes between groups, we saw a trend toward larger improvements in both primary and secondary outcomes in the @entity1 group. CONCLUSIONS: While @entity0 recruitment was found to be challenging, levels of @entity0 retention, outcome completion, and acceptability of @entity1 therapy were high. A number of lessons are presented in order to take forward a future definitive pragmatic randomized trial.

title: The Effectiveness and Cost-Effectiveness of Spinal Cord Stimulation for XXXX (RASCAL Study): A Pilot Randomized Controlled Trial.

answer: @entity2


abstract: BACKGROUND: @entity1 has become a significant public health concern in the United States. Few published data have examined the association between @entity1 and @entity2 after @entity3 ( @entity3 ). METHODS: @entity0 who underwent @entity3 were identified using the PearlDiver database Current Procedural Terminology codes. @entity0 were divided into @entity1 and nonobese cohorts using International Classification of Diseases, Ninth Revision codes. Each cohort was then assessed for major and minor complications within 90  days postoperatively. Odds ratios, 95% confidence intervals, and   (2) tests were calculated, with P  <  .05 considered significant. RESULTS: From 2005 to 2011, 7580 @entity0 who underwent @entity3 were identified, of whom 1030 @entity0 (14%) were coded as @entity1 (body mass index  >  30) and 611 @entity0 (8%) were coded as morbidly @entity1 (body mass index >  40). The @entity1 @entity3 @entity0 had increased risk of 90-day major and minor complications. The rate of postoperative @entity4 differed significantly between groups, with a trend toward a higher @entity4 rate in @entity1 @entity0 (2.2%) vs. nonobese @entity0 (0.7%). Rate of postoperative stiffness was similar between groups. Infection rates were higher in @entity1 @entity0 compared with nonobese @entity0 . Medical complications were higher in @entity1 @entity0 (16.7%) compared with the nonobese cohort (4.7%). A significant difference in implant removal was notable at 6  months and 1 year in morbidly @entity1 @entity0 compared with nonobese counterparts. CONCLUSIONS: @entity1 and associated medical comorbidities place @entity0 at increased risk for complications after @entity3 . @entity1 @entity0 and especially morbidly @entity1 @entity0 thinking of undergoing @entity3 should be appropriately counseled preoperatively about their increased risk for complications.

title: XXXX is associated with @entity2 after @entity3 .

answer: @entity1