abstract: Monocytes (Mon) and Mon-derived macrophages (Mac) orchestrate important oxidative and inflammatory reactions in @entity2 by secreting reactive oxygen species (ROS) due, in large part, to the upregulated NADPH oxidases (Nox). The Nox enzymes have been extensively investigated in @entity0 Mon and Mac. However, the expression and functional significance of the @entity5 subtypes is not known. We aimed at elucidating whether @entity5 is expressed in @entity0 Mon and Mac, and examine its potential role in @entity2 . @entity0 monocytic THP-1 cell line and @entity4 (+) Mon were employed to search for @entity5 expression. RT-PCR, Western blot, lucigenin-enhanced chemiluminescence and dihydroethidium assays were utilized to examine @entity5 in these cells. We found that @entity5 transcription variants and proteins are constitutively expressed in THP-1 cells and primary @entity4 (+) Mon. Silencing of @entity5 protein expression by siRNA reduced the Ca(2+)-dependent Nox activity and the formation of ROS in Mac induced by A23187, a selective Ca(2+) ionophore. Exposure of Mac to increasing concentrations of IFNy (5-100  ng/ml) or oxidized LDL (5-100   g/ml) resulted in a dose-dependent increase in @entity5 protein expression and elevation in intracellular Ca(2+) concentration. Immunohistochemical staining revealed that @entity5 is present in @entity1 (+) Mac-rich area within @entity0 carotid artery atherosclerotic plaques. To the best of our knowledge, this is the first evidence that @entity5 is constitutively expressed in @entity0 Mon. Induction of @entity5 expression in IFNy- and oxidized LDL-exposed Mac and the presence of @entity5 in Mac-rich @entity3 are indicative of the implication of @entity5 in atherogenesis.

title: @entity0 monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in XXXX .

answer: @entity2


abstract: Monocytes (Mon) and Mon-derived macrophages (Mac) orchestrate important oxidative and inflammatory reactions in @entity2 by secreting reactive oxygen species (ROS) due, in large part, to the upregulated NADPH oxidases (Nox). The Nox enzymes have been extensively investigated in @entity0 Mon and Mac. However, the expression and functional significance of the @entity5 subtypes is not known. We aimed at elucidating whether @entity5 is expressed in @entity0 Mon and Mac, and examine its potential role in @entity2 . @entity0 monocytic THP-1 cell line and @entity4 (+) Mon were employed to search for @entity5 expression. RT-PCR, Western blot, lucigenin-enhanced chemiluminescence and dihydroethidium assays were utilized to examine @entity5 in these cells. We found that @entity5 transcription variants and proteins are constitutively expressed in THP-1 cells and primary @entity4 (+) Mon. Silencing of @entity5 protein expression by siRNA reduced the Ca(2+)-dependent Nox activity and the formation of ROS in Mac induced by A23187, a selective Ca(2+) ionophore. Exposure of Mac to increasing concentrations of IFNy (5-100  ng/ml) or oxidized LDL (5-100   g/ml) resulted in a dose-dependent increase in @entity5 protein expression and elevation in intracellular Ca(2+) concentration. Immunohistochemical staining revealed that @entity5 is present in @entity1 (+) Mac-rich area within @entity0 carotid artery atherosclerotic plaques. To the best of our knowledge, this is the first evidence that @entity5 is constitutively expressed in @entity0 Mon. Induction of @entity5 expression in IFNy- and oxidized LDL-exposed Mac and the presence of @entity5 in Mac-rich @entity3 are indicative of the implication of @entity5 in atherogenesis.

title: XXXX monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in @entity2 .

answer: @entity0


abstract: @entity5 is a severe complication after CAPD treatment. The visceral peritoneum is thickened and interenteric adhesive parts are found. Myofibroblasts are proliferated and the collageneous tissue is hyperplastic. The mean clinical symptom is the mechanical obstruction of the small bowel. We observed this illness in three out of sixty @entity0 under CAPD. These @entity0 had higher incidence of @entity1 . In the ascites high concentrations of PG E2 and Thromboxan B2 were observed. After treatment of the infection the concentrations fell down to normal values. Electronoptical observations from peritoneal biopsies showed a proliferation of myofibroblasts and extracellular lysosomes. It is known from these lysosomes that they are able to set free proteasis. These lead to degredation of fibrin and fibrinogen. These splits are mitogen to myofibroblasts. release from HIT cells could also be evoked by the sulphonylureas @entity6 and @entity7 and by an increase in concentration of extracellular K+ to 40 mmol/l. The content of @entity3 in HIT cells was increased modestly by @entity2 but not by an increase in extracellular K+. @entity4 elicited a 4-fold increase in @entity3 content. We conclude that HIT cells retain the essential features of the insulin secretory response of normal B cells and represent an important tool for further biochemical characterisation of the secretory system.

title: [ XXXX following continuous ambulatory peritoneal dialysis].

answer: @entity5


abstract: BACKGROUND: There is poor knowledge about the evolution of the negative skin test in local @entity2 over time. Does the negative skin test of @entity0 with @entity2 remain negative permanently or does it become positive? METHODS: We describe our long-term observation concerning the evolution of the negative skin test over time. This is a retrospective, follow-up study using data from the medical records of a group of @entity0 with local @entity2 . A total of 42 @entity0 aged between 3 and 70 years (median age: 31.5 years) were studied. The duration of follow-up varied from 1 to 27 years. Skin tests were performed using the skin-prick test and intracutaneous techniques for pollen, molds, mites, feathers (goose and @entity3 ) and animal danders. Nasal provocation tests were conducted with the same allergens. Additionally, specific IgE in 17 @entity0 was measured by enzyme allergosorbent test. RESULTS: During the period of observation, the negative skin test reactions converted into positive reactions in 17 @entity0 (40%). In addition to the negative skin reactions, 55% of the @entity0 also presented positive skin reactions. The conversion rate was higher in @entity0 and adolescents than in adults. In 4 @entity0 , conversions occurred >7 years after the initial examination. Specific IgE was negative in all but 2 @entity0 , in whom the conversion in the skin test was accompanied by a switch from negative to positive specific IgE. CONCLUSION: Conversions from local to @entity1 appear to be a common phenomenon.

title: Local allergic nasal reactions convert to classic XXXX : a long-term follow-up.

answer: @entity1


abstract: UNASSIGNED: Multiple induction regimens have been developed for adult @entity0 with @entity2 ( @entity2 ). However, there have been no prospective randomized trials that directly compare these regimens. In this study, we wanted to evaluate the outcome of 50 @entity2 @entity0 treated with BFM (i.e. Berlin-Frankfurt-Munster, n = 20) and hyper-CVAD (n = 30) protocols between March 2006 and October 2012. The median age was 25 years in the BFM group and 30.5 years in the hyper-CVAD group with a male/female ratio of 15:5 and 17:13, respectively. Forty-five percent of the @entity0 in the BFM group and 30.3% in the hyper-CVAD group were <25 years old. The majority of cases were B cell in origin (80% in the BFM group and 70% in the hyper-CVAD group). Complete remission after induction therapy was achieved in 95 and 96% of the @entity0 , respectively. The median follow-up time was 37 months. The 5-year survival rate was higher in the BFM group than in the hyper-CVAD group (59 vs. 34%). There were also no complications which could cause a delay during the hyper-CVAD regimen. Both chemotherapies were well tolerated. None of the @entity0 died from drug-related @entity1 . Only mild liver enzyme elevations were seen as @entity1 in the BFM group; these did not cause any delay in therapy. The BFM regimen seems to be feasible for adult @entity0 with @entity2 in terms of tolerability and efficacy, especially in young adults.    2015 S. Karger AG, Basel.

title: Is the BFM Regimen Feasible for the Treatment of Adult XXXX ? A Retrospective Analysis of the Outcomes of BFM and Hyper-CVAD Chemotherapy in Two Centers.

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ) @entity0 are prone to both hypo- and @entity8 . Little has been published on the epidemiology of hypo- and @entity8 in ambulatory @entity0 with non-dialysis @entity5 . METHODS: Data collected in two contemporaneous @entity5 cohort studies, the @entity1 ( @entity1 )- @entity5 study (n = 834) and the Study of Treatment of @entity2 : Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum @entity7 ( @entity9 ) and clinical outcomes. RESULTS: Baseline estimated glomerular filtration rate (eGFR) and @entity9 were 26    11 ml/ @entity6 .73 m(2) and 140.2    3.4 mEq/l, respectively. The prevalence of @entity9  <=135 mEq/l and >= 144 mEq/l was 6 and 16%, respectively. Higher baseline @entity9 was significantly associated with male sex, older age, systolic blood pressure, BMI, serum albumin, presence of @entity4 , and lower eGFR. The risk of @entity3 ( @entity3 ) was marginally significantly higher among @entity0 with @entity9  <=135 mEq/l, compared with 140< @entity9 <144 mEq/l (referent), in time-dependent models (adjusted hazard ratio, HR = 1.52, p = 0.06). Mortality risk was significantly greater at 135< @entity9  <=140 mEq/l (adjusted HR = 1.68, p = 0.02) and @entity9 >= 144 mEq/l (adjusted HR = 2.01, p = 0.01). CONCLUSION: @entity5 @entity0 with @entity9  <=135 mEq/l were at a higher risk for progression to @entity3 , whereas both lower and higher @entity9 levels were associated with a higher risk of mortality. While caring for @entity5 @entity0 , greater attention to serum @entity7 levels by clinicians is warranted and could potentially help improve @entity0 outcomes.    2015 S. Karger AG, Basel.

title: Serum @entity7 Levels and @entity0 Outcomes in an Ambulatory Clinic-Based XXXX Cohort.

answer: @entity5


abstract: BACKGROUND: @entity5 ( @entity5 ) @entity0 are prone to both hypo- and @entity8 . Little has been published on the epidemiology of hypo- and @entity8 in ambulatory @entity0 with non-dialysis @entity5 . METHODS: Data collected in two contemporaneous @entity5 cohort studies, the @entity1 ( @entity1 )- @entity5 study (n = 834) and the Study of Treatment of @entity2 : Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum @entity7 ( @entity9 ) and clinical outcomes. RESULTS: Baseline estimated glomerular filtration rate (eGFR) and @entity9 were 26    11 ml/ @entity6 .73 m(2) and 140.2    3.4 mEq/l, respectively. The prevalence of @entity9  <=135 mEq/l and >= 144 mEq/l was 6 and 16%, respectively. Higher baseline @entity9 was significantly associated with male sex, older age, systolic blood pressure, BMI, serum albumin, presence of @entity4 , and lower eGFR. The risk of @entity3 ( @entity3 ) was marginally significantly higher among @entity0 with @entity9  <=135 mEq/l, compared with 140< @entity9 <144 mEq/l (referent), in time-dependent models (adjusted hazard ratio, HR = 1.52, p = 0.06). Mortality risk was significantly greater at 135< @entity9  <=140 mEq/l (adjusted HR = 1.68, p = 0.02) and @entity9 >= 144 mEq/l (adjusted HR = 2.01, p = 0.01). CONCLUSION: @entity5 @entity0 with @entity9  <=135 mEq/l were at a higher risk for progression to @entity3 , whereas both lower and higher @entity9 levels were associated with a higher risk of mortality. While caring for @entity5 @entity0 , greater attention to serum @entity7 levels by clinicians is warranted and could potentially help improve @entity0 outcomes.    2015 S. Karger AG, Basel.

title: Serum XXXX Levels and @entity0 Outcomes in an Ambulatory Clinic-Based @entity5 Cohort.

answer: @entity7


abstract: BACKGROUND: @entity5 ( @entity5 ) @entity0 are prone to both hypo- and @entity8 . Little has been published on the epidemiology of hypo- and @entity8 in ambulatory @entity0 with non-dialysis @entity5 . METHODS: Data collected in two contemporaneous @entity5 cohort studies, the @entity1 ( @entity1 )- @entity5 study (n = 834) and the Study of Treatment of @entity2 : Data and Evaluation (STRIDE) (n = 1,348) were combined and analyzed to study the association between serum @entity7 ( @entity9 ) and clinical outcomes. RESULTS: Baseline estimated glomerular filtration rate (eGFR) and @entity9 were 26    11 ml/ @entity6 .73 m(2) and 140.2    3.4 mEq/l, respectively. The prevalence of @entity9  <=135 mEq/l and >= 144 mEq/l was 6 and 16%, respectively. Higher baseline @entity9 was significantly associated with male sex, older age, systolic blood pressure, BMI, serum albumin, presence of @entity4 , and lower eGFR. The risk of @entity3 ( @entity3 ) was marginally significantly higher among @entity0 with @entity9  <=135 mEq/l, compared with 140< @entity9 <144 mEq/l (referent), in time-dependent models (adjusted hazard ratio, HR = 1.52, p = 0.06). Mortality risk was significantly greater at 135< @entity9  <=140 mEq/l (adjusted HR = 1.68, p = 0.02) and @entity9 >= 144 mEq/l (adjusted HR = 2.01, p = 0.01). CONCLUSION: @entity5 @entity0 with @entity9  <=135 mEq/l were at a higher risk for progression to @entity3 , whereas both lower and higher @entity9 levels were associated with a higher risk of mortality. While caring for @entity5 @entity0 , greater attention to serum @entity7 levels by clinicians is warranted and could potentially help improve @entity0 outcomes.    2015 S. Karger AG, Basel.

title: Serum @entity7 Levels and XXXX Outcomes in an Ambulatory Clinic-Based @entity5 Cohort.

answer: @entity0


abstract: BACKGROUND: In Australia, high-risk @entity1 (HR HPV) testing is recommended for follow-up of @entity0 treated for a @entity2 ( @entity2 ). The sensitivity of HR HPV testing is critical to identify @entity0 at risk of further high-grade cervical disease. In Australia, this management protocol is known as the 'Test of Cure' (ToC). AIM: To conduct a population-based study investigating practitioners' compliance with ToC. MATERIALS AND METHODS: @entity0 treated for an @entity2 between the five-year period 01 Jan 2006 to 31 Dec 2010 were identified and followed up for at least a 27-month period. Proportions and relative odds were determined for @entity0 entering and completing the ToC management pathway within recommended time frames. RESULTS: There were 5,194 @entity0 identified as 'eligible' to enter the ToC management pathway. Of these, 1,916 (37%) were managed with annual Pap smears and never had a HR HPV test performed. There were 1,296 (25%) @entity0 who entered the ToC management pathway within recommended time frames, and a further 1,978 (38%) @entity0 entered outside of the recommended time frames. Overall, 961 @entity0 completed the ToC and were classified as 'cured' and were eligible to return to two-yearly Pap smears. @entity0 's demographic information was significantly associated with ToC commencement, specifically, age and year of treatment, and Index of Relative Socioeconomic Disadvantage. CONCLUSION: Overall, a significant number of Australian @entity0 did not enter (~37%) and complete (~50%) the ToC management pathway. The challenge remains to advocate its use to practitioners to ensure @entity0 are returned to the population screening interval in a timely manner.

title: The XXXX Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer.

answer: @entity1


abstract: RATIONALE: Spatial working memory is dependent on the appropriate functioning of the prefrontal cortex (PFC). PFC activity can be modulated by @entity2 (NA) released by afferent projections from the locus coeruleus. The coreuleo-cortical NA system could therefore be a target for @entity1 . Of the three classes of NA receptor potentially involved, the a2 and a1 classes seem most significant, though agents targeting these receptors have yielded mixed results. This may be partially due to the use of behavioural assays that do not translate effectively from the laboratory to the clinical setting. Use of a paradigm with improved translational potential may be essential to resolve these discrepancies. OBJECTIVES: The objective of this study was to assess the effects of PFC-infused a2 and a1 adrenergic receptor agonists on spatial working memory performance in the touchscreen continuous trial-unique non-matching to location (cTUNL) task in @entity0 . METHODS: Young male @entity0 were trained in the cTUNL paradigm. Cannulation of the mPFC allowed direct administration of @entity3 agonists for task validation, and @entity6 and @entity5 to determine the effects of adrenergic agonists on task performance. RESULTS: Infusion of @entity7 and @entity4 resulted in a @entity1 . Administration of the a2 agonist @entity5 had no effect, whilst infusion of the a1 agonist @entity6 significantly improved working memory performance. CONCLUSIONS: Spatial working memory as measured in the @entity0 cTUNL task is dependent on the mPFC. Enhancement of noradrenergic signalling enhanced performance in this paradigm, suggesting a significant role for the a1 receptor in this facilitation.

title: Facilitation of spatial working memory performance following intra-prefrontal cortical administration of the adrenergic alpha1 agonist XXXX .

answer: @entity6


abstract: OBJECTIVE: To determine whether @entity3 ( @entity3 ) parameters assessed by transvaginal sonography (TVS) might impact the early medical abortion outcome. METHODS: @entity0 with previous cesarean delivery who received oral @entity4 and @entity2 for medical abortion were reviewed retrospectively. A successful medical abortion was defined as the absence of intrauterine gestational sac and without surgical intervention. @entity3 was diagnosed in the presence of a hypoechogenic indentation within the myometrium of the lower uterine segment at the site of a previous cesarean incision by TVS. The ratio of the remaining myometrium thickness over the defect and the adjacent myometrial thickness was divided into three groups (<30%, 30%-70%, and >70%). RESULTS: Of 183 @entity0 , 43 (23.5%) had medical @entity1 , 59 (32.2%) with detectable CSDs had a higher failure rate than those without CSDs (38.9% vs. 16.1%; P   =   0.001). CSDs were significantly associated with medical @entity1 (OR   =   3.32, 95% CI: 1.63-6.75). The failure rates in relation to the defect size in the <30%, 30%-70%, and >70% groups were 57.1%, 25.0%, and 18.2%, respectively. A linear trend was observed in failure rates of medical abortion across these ratios (Cochran-Armitage trend test; P   =   0.015). CONCLUSIONS: @entity0 with @entity3 are at increased risk of failed medical abortion. @entity0 with a defect with the remaining myometrium less than 30% of the adjacent myometrial thickness tended to have higher failed medical abortions. Detectable @entity3 is of clinical relevance in counseling @entity0 with history of cesarean deliveries for medical abortion.

title: Ultrasonographic parameters of XXXX in correlation with the outcome of early medical abortion.

answer: @entity3


abstract: UNASSIGNED: To evaluate a forward-sensing fiber-optic pressure technique for recording of intramuscular pressure (IMP) in the @entity0 leg and investigate factors that may influence IMP measurements used in diagnosing compartment syndromes. IMP in the tibialis anterior muscle was recorded simultaneously by a fiber-optic technique and needle-injection technique in 12 legs of 7 healthy subjects. Both measurement catheters were placed in parallel with the muscle fibers to the same depth, as verified by sonography. IMP recordings were performed at rest before, during and after applying a model of abnormally elevated IMP (simulated @entity3 ). IMP was elevated by @entity1 induced by a thigh tourniquet of a casted leg. IMP was also measured during injections of 0.1  ml of saline into the muscle through the catheters. IMP at baseline was 5.1 (SD  =  2.6) mmHg measured with the fiber-optic technique and 7.1 (SD  =  2.5) mmHg with the needle-injection technique (p  <  0.001). It increased to 48.5 (SD  =  6.9) mmHg and 47.6 (SD  =  6.6) mmHg respectively, during simulated @entity3 . IMP increased significantly following injection of 0.1  ml of saline, measured by both techniques. It remained increased 1  min after injection. The fiber-optic technique was able to record pulse-synchronous @entity2 . The fiber-optic technique may be used for IMP measurements in a muscle with both normal and abnormally elevated IMP. It has good dynamic properties allowing for measurement of @entity2 . Saline injection used with needle-injection systems to ensure catheter patency compromises IMP readings at least one minute after injection.

title: Evaluation of a fiber-optic technique for recording intramuscular pressure in the XXXX leg.

answer: @entity0


abstract: BACKGROUND _ AIMS: @entity2 ( @entity2 ) may cause @entity1 in @entity0 with @entity3 . Investigational studies demonstrated reversibility of @entity1 after drug withdrawal, but information based on clinical practice is lacking. The aim of the study was to investigate the characteristics and outcome of @entity4 ( @entity4 ) developing in @entity0 with @entity3 treated with @entity2 . METHODS: Prospective cohort study in a tertiary referral center of all @entity0 with @entity2 -associated @entity4 seen from 2002 to 2014. For comparison, three control groups of @entity0 with @entity6 -induced @entity4 , type-1 @entity7 and @entity8 , respectively, were also evaluated. Urinary excretion of neutrophil gelatinase-associated lipocalin (uNGAL) was measured in a subset of @entity0 . RESULTS: Thirty @entity0 with @entity3 and @entity2 -associated @entity4 were identified. In 19 @entity0 (63%) @entity4 was @entity1 rapidly recovered (4  3days) after @entity2 withdrawal. In the remaining 11 @entity0 (37%) @entity4 was more severe and persisted during hospitalization despite drug withdrawal. @entity0 with persistent @entity4 had remarkably higher uNGAL levels compared with those of @entity0 with transient @entity4 (953  1,198 vs. 83  79 g/g of @entity5 , respectively, p=0.008). Moreover, seven of the 11 @entity0 with persistent @entity4 (64%) died within three months compared with only one of the 19 (5%) @entity0 with transient @entity4 (p=0.001). Mortality of persistent @entity4 was similar in @entity2 @entity0 compared to control groups. The only independent predictive factor of three-month mortality was persistent @entity4 . CONCLUSIONS: @entity0 with @entity3 treated with @entity2 may develop severe @entity4 which may be irreversible and associated with poor short-term outcome.

title: Severe @entity4 associated with non-steroidal anti-inflammatory drugs in XXXX : A case-control study.

answer: @entity3


abstract: BACKGROUND _ AIMS: @entity2 ( @entity2 ) may cause @entity1 in @entity0 with @entity3 . Investigational studies demonstrated reversibility of @entity1 after drug withdrawal, but information based on clinical practice is lacking. The aim of the study was to investigate the characteristics and outcome of @entity4 ( @entity4 ) developing in @entity0 with @entity3 treated with @entity2 . METHODS: Prospective cohort study in a tertiary referral center of all @entity0 with @entity2 -associated @entity4 seen from 2002 to 2014. For comparison, three control groups of @entity0 with @entity6 -induced @entity4 , type-1 @entity7 and @entity8 , respectively, were also evaluated. Urinary excretion of neutrophil gelatinase-associated lipocalin (uNGAL) was measured in a subset of @entity0 . RESULTS: Thirty @entity0 with @entity3 and @entity2 -associated @entity4 were identified. In 19 @entity0 (63%) @entity4 was @entity1 rapidly recovered (4  3days) after @entity2 withdrawal. In the remaining 11 @entity0 (37%) @entity4 was more severe and persisted during hospitalization despite drug withdrawal. @entity0 with persistent @entity4 had remarkably higher uNGAL levels compared with those of @entity0 with transient @entity4 (953  1,198 vs. 83  79 g/g of @entity5 , respectively, p=0.008). Moreover, seven of the 11 @entity0 with persistent @entity4 (64%) died within three months compared with only one of the 19 (5%) @entity0 with transient @entity4 (p=0.001). Mortality of persistent @entity4 was similar in @entity2 @entity0 compared to control groups. The only independent predictive factor of three-month mortality was persistent @entity4 . CONCLUSIONS: @entity0 with @entity3 treated with @entity2 may develop severe @entity4 which may be irreversible and associated with poor short-term outcome.

title: Severe XXXX associated with non-steroidal anti-inflammatory drugs in @entity3 : A case-control study.

answer: @entity4


abstract: A study on clinical and histological features of prognostic significance was performed in 45 @entity0 with Ph1+ - @entity4 who showed median survival of 36 months. The histological features were evaluated by morphometry of iliac crest biopsies. Among the variables correlated with prognosis, we eliminated those without primary importance by mutual univariate retrospective stratification. Thus a clinical and a histological set of important prognostic criteria was established. Their influence on prognosis proved to be independent of each other and therefore could be used for separate classifications. Clinical classification yielded two groups with different prognosis: compared to the rest of the @entity0 , the prognosis was much worse for those with a spleen size greater than 10 cm, a liver size greater than 2 cm (below costal margin) and greater than 5% circulating blasts plus promyelocytes. The histomorphological classification consisted of three subgroups: a better than average prognosis was found for @entity0 with pseudo-Gaucher cells in the bone marrow, while in the remaining cases the prognosis was worse in @entity0 with a high number of megakaryocytes (greater than 70/ @entity2 ) and a low volume ratio of granulopoiesis: megakaryocytes (less than 15). Since liver size was correlated with the duration of prediagnostic symptoms, the clinical classification probably reflects different disease stages, i.e. a later @entity4 diagnosis. However, the histological set of prognostic factors is independent of the length of the prediagnostic period. Consequently, this morphological classification seems to discriminate different subgroups. Another important prognostic factor, marrow @entity1 , was independent of other histomorphological features, and correlated with duration of symptoms. It obviously also indicates more @entity3 .

title: The prognostic implication of clinical and histological features in Ph1+ @entity4 ( XXXX ).

answer: @entity4


abstract: A study on clinical and histological features of prognostic significance was performed in 45 @entity0 with Ph1+ - @entity4 who showed median survival of 36 months. The histological features were evaluated by morphometry of iliac crest biopsies. Among the variables correlated with prognosis, we eliminated those without primary importance by mutual univariate retrospective stratification. Thus a clinical and a histological set of important prognostic criteria was established. Their influence on prognosis proved to be independent of each other and therefore could be used for separate classifications. Clinical classification yielded two groups with different prognosis: compared to the rest of the @entity0 , the prognosis was much worse for those with a spleen size greater than 10 cm, a liver size greater than 2 cm (below costal margin) and greater than 5% circulating blasts plus promyelocytes. The histomorphological classification consisted of three subgroups: a better than average prognosis was found for @entity0 with pseudo-Gaucher cells in the bone marrow, while in the remaining cases the prognosis was worse in @entity0 with a high number of megakaryocytes (greater than 70/ @entity2 ) and a low volume ratio of granulopoiesis: megakaryocytes (less than 15). Since liver size was correlated with the duration of prediagnostic symptoms, the clinical classification probably reflects different disease stages, i.e. a later @entity4 diagnosis. However, the histological set of prognostic factors is independent of the length of the prediagnostic period. Consequently, this morphological classification seems to discriminate different subgroups. Another important prognostic factor, marrow @entity1 , was independent of other histomorphological features, and correlated with duration of symptoms. It obviously also indicates more @entity3 .

title: The prognostic implication of clinical and histological features in Ph1+ XXXX ( @entity4 ).

answer: @entity4


abstract: UNASSIGNED: Amyloid b (Ab) peptides are identified in cause of @entity2 such as @entity3 ( @entity3 ). Previous evidence suggests Ab-induced @entity5 is linked to the stimulation of reactive @entity0 species (ROS) production. The accumulation of Ab-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be beneficial for preventing ROS-related diseases such as @entity3 . Recently, @entity6 -rich water (HRW) has been proven effective in treating oxidative stress-induced disorders because of its ROS-scavenging abilities. However, the precise molecular mechanisms whereby HRW prevents @entity4 are still unclear. In the present study, we evaluated the putative pathways by which HRW protects against Ab-induced @entity1 . Our results indicated that HRW directly counteracts oxidative damage by neutralizing excessive ROS, leading to the alleviation of Ab-induced cell death. In addition, HRW also stimulated @entity8 -activated protein kinase (AMPK) in a @entity7 ( @entity7 )-dependent pathway, which upregulates forkhead box protein O3a ( @entity9 ) downstream antioxidant response and diminishes Ab-induced mitochondrial potential loss and oxidative stress. Taken together, our findings suggest that HRW may have potential therapeutic value to inhibit Ab-induced @entity5 .

title: @entity6 -rich water attenuates amyloid b-induced @entity1 through upregulation of @entity7 - XXXX by stimulation of @entity8 -activated protein kinase in SK-N-MC cells.

answer: @entity9


abstract: UNASSIGNED: Amyloid b (Ab) peptides are identified in cause of @entity2 such as @entity3 ( @entity3 ). Previous evidence suggests Ab-induced @entity5 is linked to the stimulation of reactive @entity0 species (ROS) production. The accumulation of Ab-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be beneficial for preventing ROS-related diseases such as @entity3 . Recently, @entity6 -rich water (HRW) has been proven effective in treating oxidative stress-induced disorders because of its ROS-scavenging abilities. However, the precise molecular mechanisms whereby HRW prevents @entity4 are still unclear. In the present study, we evaluated the putative pathways by which HRW protects against Ab-induced @entity1 . Our results indicated that HRW directly counteracts oxidative damage by neutralizing excessive ROS, leading to the alleviation of Ab-induced cell death. In addition, HRW also stimulated @entity8 -activated protein kinase (AMPK) in a @entity7 ( @entity7 )-dependent pathway, which upregulates forkhead box protein O3a ( @entity9 ) downstream antioxidant response and diminishes Ab-induced mitochondrial potential loss and oxidative stress. Taken together, our findings suggest that HRW may have potential therapeutic value to inhibit Ab-induced @entity5 .

title: @entity6 -rich water attenuates amyloid b-induced @entity1 through upregulation of XXXX - @entity9 by stimulation of @entity8 -activated protein kinase in SK-N-MC cells.

answer: @entity7


abstract: UNASSIGNED: Amyloid b (Ab) peptides are identified in cause of @entity2 such as @entity3 ( @entity3 ). Previous evidence suggests Ab-induced @entity5 is linked to the stimulation of reactive @entity0 species (ROS) production. The accumulation of Ab-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be beneficial for preventing ROS-related diseases such as @entity3 . Recently, @entity6 -rich water (HRW) has been proven effective in treating oxidative stress-induced disorders because of its ROS-scavenging abilities. However, the precise molecular mechanisms whereby HRW prevents @entity4 are still unclear. In the present study, we evaluated the putative pathways by which HRW protects against Ab-induced @entity1 . Our results indicated that HRW directly counteracts oxidative damage by neutralizing excessive ROS, leading to the alleviation of Ab-induced cell death. In addition, HRW also stimulated @entity8 -activated protein kinase (AMPK) in a @entity7 ( @entity7 )-dependent pathway, which upregulates forkhead box protein O3a ( @entity9 ) downstream antioxidant response and diminishes Ab-induced mitochondrial potential loss and oxidative stress. Taken together, our findings suggest that HRW may have potential therapeutic value to inhibit Ab-induced @entity5 .

title: @entity6 -rich water attenuates amyloid b-induced XXXX through upregulation of @entity7 - @entity9 by stimulation of @entity8 -activated protein kinase in SK-N-MC cells.

answer: @entity1


abstract: UNASSIGNED: Amyloid b (Ab) peptides are identified in cause of @entity2 such as @entity3 ( @entity3 ). Previous evidence suggests Ab-induced @entity5 is linked to the stimulation of reactive @entity0 species (ROS) production. The accumulation of Ab-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be beneficial for preventing ROS-related diseases such as @entity3 . Recently, @entity6 -rich water (HRW) has been proven effective in treating oxidative stress-induced disorders because of its ROS-scavenging abilities. However, the precise molecular mechanisms whereby HRW prevents @entity4 are still unclear. In the present study, we evaluated the putative pathways by which HRW protects against Ab-induced @entity1 . Our results indicated that HRW directly counteracts oxidative damage by neutralizing excessive ROS, leading to the alleviation of Ab-induced cell death. In addition, HRW also stimulated @entity8 -activated protein kinase (AMPK) in a @entity7 ( @entity7 )-dependent pathway, which upregulates forkhead box protein O3a ( @entity9 ) downstream antioxidant response and diminishes Ab-induced mitochondrial potential loss and oxidative stress. Taken together, our findings suggest that HRW may have potential therapeutic value to inhibit Ab-induced @entity5 .

title: XXXX -rich water attenuates amyloid b-induced @entity1 through upregulation of @entity7 - @entity9 by stimulation of @entity8 -activated protein kinase in SK-N-MC cells.

answer: @entity6


abstract: UNASSIGNED: Amyloid b (Ab) peptides are identified in cause of @entity2 such as @entity3 ( @entity3 ). Previous evidence suggests Ab-induced @entity5 is linked to the stimulation of reactive @entity0 species (ROS) production. The accumulation of Ab-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be beneficial for preventing ROS-related diseases such as @entity3 . Recently, @entity6 -rich water (HRW) has been proven effective in treating oxidative stress-induced disorders because of its ROS-scavenging abilities. However, the precise molecular mechanisms whereby HRW prevents @entity4 are still unclear. In the present study, we evaluated the putative pathways by which HRW protects against Ab-induced @entity1 . Our results indicated that HRW directly counteracts oxidative damage by neutralizing excessive ROS, leading to the alleviation of Ab-induced cell death. In addition, HRW also stimulated @entity8 -activated protein kinase (AMPK) in a @entity7 ( @entity7 )-dependent pathway, which upregulates forkhead box protein O3a ( @entity9 ) downstream antioxidant response and diminishes Ab-induced mitochondrial potential loss and oxidative stress. Taken together, our findings suggest that HRW may have potential therapeutic value to inhibit Ab-induced @entity5 .

title: @entity6 -rich water attenuates amyloid b-induced @entity1 through upregulation of @entity7 - @entity9 by stimulation of XXXX -activated protein kinase in SK-N-MC cells.

answer: @entity8


abstract: BACKGROUND: As @entity0 live longer, their risk of disability increases. Disability affects quality of life and increases health and social care costs. Preventing or delaying disability is therefore an important objective, and identifying an effective intervention could improve the lives of many older @entity0 . Observational and interventional evidence suggests that physical activity may reduce the risk of age-related disability, as assessed by physical performance measures. However it is unclear what approach is the most cost-effective intervention in changing long-term physical activity behaviour in older adults. A new theory-driven behavioural intervention has been developed, with the aim of increasing physical activity in the everyday lives of older adults at risk of disability. This pilot study tests the feasibility and acceptability of delivering this intervention to older adults. METHODS/DESIGN: A @entity1 ( @entity1 ) design will be used in the pilot study. Sixty @entity0 aged 65 years and older will be recruited from primary care practices. @entity0 will be eligible to participate if they are inactive, not disabled at baseline, are at risk of developing disability in the future (Short Physical Performance Battery score <10/12), and have no contraindications to physical activity. Following baseline measures, @entity0 will be randomised in a 2:1 ratio to the intervention or to a control arm and all @entity0 will be followed-up after 6 months. Those randomised to the intervention arm will receive sessions with a trained Physical Activity Facilitator, delivering an intervention based on self-determination theory. Control @entity0 receive a booklet on healthy ageing. The main outcomes of interest are recruitment, adherence, retention and acceptability. Data will also be collected on: self-report and accelerometer-recorded physical activity; physical performance; @entity2 ; wellbeing; cognitive function; social support; quality of life, healthcare use, and attitudes to physical activity. A mixed-methods process evaluation will run alongside the @entity1 . DISCUSSION: The intervention, if effective, has the potential to reduce disability and improve quality of life in older adults. Before proceeding to a full-scale trial a pilot trial is necessary to ensure intervention feasibility and acceptability, and that the intervention shows evidence of promise. TRIAL REGISTRATION: Current Controlled Trials ISRCTN80470273 . Registered 25 October 2013.

title: Physical ACtivity facilitation for Elders (PACE): study protocol for a XXXX .

answer: @entity1


abstract: INTRODUCTION: @entity0 who are surgically treated for an acute @entity1 in Denmark commence early in-hospital physical rehabilitation (PR) with more than 95% of @entity0 referred to further PR following discharge. However, the specifics of the PR services after discharge are unknown. Thus, the aim of the present paper was to describe the specifics of PR provided to @entity0 following discharge after @entity1 ( @entity1 ) surgery in Denmark to evaluate the need for future interventions or guidelines. METHODS: This was a national, cross-sectional questionnaire survey including 56 randomly selected municipalities out of 98. Information was gathered on PR and categorised into outpatient PR (including one-to-one and group), home-based PR, 24-hour in- @entity0 PR units and nursing homes. RESULTS: Sixty PR centres (97%) within 51 municipalities (91%) participated. The PR was initiated within 1-2 weeks after the municipality had received a referral from the hospital in 97% of the participating centres. The duration of PR was 8-12 weeks or 4-7 weeks in 85% of the centres, and most often comprised 1-2 training sessions per week. In all, 72% out of 56 municipalities returned a specific PR programme of which only 14% provided specific information regarding the intensity and the progression of training. CONCLUSION: PR after @entity1 in Denmark is initiated shortly after referral, for a variable duration of time and with poorly described exercise intensity and progression. This calls for a national description and implementation of an optimised PR programme according to the best available evidence. FUNDING: The study was supported by grants from The IMK Foundation, The Research Foundation of the Capital Region, The Research Foundation of the Danish Physical Therapy Organization, The Research Foundation of Hvidovre Hospital and The UCSF Lundbeck Foundation. The funding agencies had no influence on the study design, methods, subjects, data collection, analyses or on the manuscript. TRIAL REGISTRATION: not relevant.

title: Municipality-based physical rehabilitation after acute XXXX surgery in Denmark.

answer: @entity1


abstract: OBJECTIVE: To evaluate clinicopathologic characteristics and treatment outcomes of @entity0 undergoing @entity5 ( @entity5 ) or radical nephrectomy (RN) for unilateral synchronous multifocal @entity3 . METHODS: We retrospectively reviewed medical records for 128 @entity0 with nonmetastatic, unilateral, synchronous, multifocal @entity3 who underwent surgical resection at our institution from 1995 to 2012. Five @entity0 with @entity4 were excluded. Differences between @entity0 and @entity1 characteristics from the 2 nephrectomy groups were evaluated. Outcomes in terms of recurrence-free survival, overall survival, and chronic @entity2 upstaging were estimated using Kaplan-Meier methods. The log-rank test was used for group comparisons. RESULTS: The study cohort included 78 @entity5 @entity0 (63%) and 45 RN @entity0 (37%); 17 of 95 planned @entity5 (18%) were converted to RN. @entity1 diameter and RENAL nephrometry scores were greater in RN @entity0 (P <.0001 and P = .0002, respectively). Pathologic stage T3 was seen in 40% of RN @entity0 and 10% of @entity5 @entity0 (P = .0002). Histologic concordance was apparent in 60 of 123 @entity0 (49%). Median follow-up for @entity0 alive without a recurrence was 4 years. Five-year recurrence-free survival was 98% for @entity5 and 85% for RN. Five-year overall survival was 96% for @entity5 and 86% for RN (P = .5). Five-year freedom from chronic @entity2 upstaging was 74% for @entity5 and 55% for RN (P = .11). CONCLUSION: Partial nephrectomy for the treatment of unilateral, synchronous, multifocal, @entity3 with favorable characteristics was associated with a low recurrence rate. These findings suggest @entity5 is an appropriate management strategy for this group of carefully selected @entity0 .

title: Partial and Radical Nephrectomy for Unilateral Synchronous Multifocal Renal Cortical XXXX .

answer: @entity1


abstract: This study aimed at determining the clinical efficacy and clinical and biological safety of @entity3 compared to @entity1 . 44 @entity0 were included, and 41 were evaluable. 33 @entity0 were treated according to the randomization list, whereas 11 @entity0 were treated in an open study. All @entity0 were suffering from acute, recurrent or chronic, lower @entity4 . 29 @entity0 started @entity3 treatment with a dosage of 200 mg or 300 mg b.i.d., and 15 other @entity0 received 1 g @entity1 b.i.d. or t.i.d. Three @entity0 of this last group were treated with @entity3 after @entity1 treatment failure. Bacteriological eradication was achieved in 95% of @entity3 -treated and in 78% of @entity1 -treated @entity0 . Clinical cure occurred in 86% of @entity3 - and in 55% of @entity1 -treated @entity0 . Successful treatment (bacteriologic eradication associated with clinical cure) was observed in 75% of @entity0 from the @entity3 -group and in 36% of the @entity1 -group. No clinical adverse reactions were seen in @entity1 -treated @entity0 , whereas one @entity0 in the @entity3 -group was complaining of mild, definitely drug-related, @entity2 . No major drug-related disturbances of biological parameters were observed neither in the @entity3 - nor in the @entity1 -group.

title: @entity3 in lower XXXX --a comparison with @entity1 .

answer: @entity4


abstract: This study aimed at determining the clinical efficacy and clinical and biological safety of @entity3 compared to @entity1 . 44 @entity0 were included, and 41 were evaluable. 33 @entity0 were treated according to the randomization list, whereas 11 @entity0 were treated in an open study. All @entity0 were suffering from acute, recurrent or chronic, lower @entity4 . 29 @entity0 started @entity3 treatment with a dosage of 200 mg or 300 mg b.i.d., and 15 other @entity0 received 1 g @entity1 b.i.d. or t.i.d. Three @entity0 of this last group were treated with @entity3 after @entity1 treatment failure. Bacteriological eradication was achieved in 95% of @entity3 -treated and in 78% of @entity1 -treated @entity0 . Clinical cure occurred in 86% of @entity3 - and in 55% of @entity1 -treated @entity0 . Successful treatment (bacteriologic eradication associated with clinical cure) was observed in 75% of @entity0 from the @entity3 -group and in 36% of the @entity1 -group. No clinical adverse reactions were seen in @entity1 -treated @entity0 , whereas one @entity0 in the @entity3 -group was complaining of mild, definitely drug-related, @entity2 . No major drug-related disturbances of biological parameters were observed neither in the @entity3 - nor in the @entity1 -group.

title: @entity3 in lower @entity4 --a comparison with XXXX .

answer: @entity1


abstract: This study aimed at determining the clinical efficacy and clinical and biological safety of @entity3 compared to @entity1 . 44 @entity0 were included, and 41 were evaluable. 33 @entity0 were treated according to the randomization list, whereas 11 @entity0 were treated in an open study. All @entity0 were suffering from acute, recurrent or chronic, lower @entity4 . 29 @entity0 started @entity3 treatment with a dosage of 200 mg or 300 mg b.i.d., and 15 other @entity0 received 1 g @entity1 b.i.d. or t.i.d. Three @entity0 of this last group were treated with @entity3 after @entity1 treatment failure. Bacteriological eradication was achieved in 95% of @entity3 -treated and in 78% of @entity1 -treated @entity0 . Clinical cure occurred in 86% of @entity3 - and in 55% of @entity1 -treated @entity0 . Successful treatment (bacteriologic eradication associated with clinical cure) was observed in 75% of @entity0 from the @entity3 -group and in 36% of the @entity1 -group. No clinical adverse reactions were seen in @entity1 -treated @entity0 , whereas one @entity0 in the @entity3 -group was complaining of mild, definitely drug-related, @entity2 . No major drug-related disturbances of biological parameters were observed neither in the @entity3 - nor in the @entity1 -group.

title: XXXX in lower @entity4 --a comparison with @entity1 .

answer: @entity3


abstract: UNASSIGNED: More female soldiers are now  serving in combat theaters than at any other time. However, little is known about possible sex differences underlying the neuropathology and manifestation of one of modern war's signature injuries, @entity0 ( @entity0 ). The paucity of information regarding sex differences in @entity0 is particularly evident when examining changes in executive function and emotion regulation associated with post concussive events. The current study objective was to observe whether patterns of orbitofrontal ( @entity2 ) functional connectivity would differ between female veterans with @entity0 and their male counterparts. The study further sought to determine whether @entity2 connectivity might be differentially associated with clinical measures of @entity1 and hostility. Seventeen female veterans and 24 male veterans, age 18 to 25, who met criteria for @entity0 completed resting state magnetic resonance imaging (MRI) and clinical assessment measures. Imaging data were analyzed using left and right seed regions of the @entity2 , and regression analyses were conducted to observe the relationship between resting state connectivity and self-reported @entity1 . Females and males in this study differed in @entity2 connectivity, with females demonstrating greater connectivity between left and right @entity2 and parietal and occipital regions and males demonstrating greater connectivity between left and right @entity2 and frontal and temporal regions. Significant associations between resting state connectivity and clinical measures were found only in male veterans. These findings suggest that @entity0 may interact with sex-specific patterns of brain connectivity in male and female veterans and exert divergent effects on clinical profiles of @entity1 post-injury.

title: Sex differences in orbitofrontal connectivity in male and female veterans with XXXX .

answer: @entity0


abstract: OBJECTIVE: To determine the importance of a symptom of @entity3 . MATERIAL AND METHODS: The results of examining 95 @entity0 aged 62-92 years with the symptoms of @entity2 in the Netanya State Geriatric Center (Israel) in 1994-2004 were analyzed. Standard X-ray study of the upper digestive tract was complemented by provocation tests. The length of an X-ray-negative area (XNA) between barium in the esophagus and stomach and the width in the lower esophagus were measured. RESULTS: Only 2 (2%) of the 95 @entity0 were found to have normal function of the gastroesophageal junction (GEJ). Two @entity0 with a drastic esophageal narrowing due to @entity1 were excluded. The remaining (91) @entity0 were divided into 2 groups. The width of the esophagus was less than 2 cm and 2 cm or more in 64 (70%) and 27 (30%) @entity0 , respectively. In weak GEJ, there was esophageal dilatation above the XNA. When in a horizontal position, this portion of the esophagus evacuates its contents into the stomach as a result of ampullary function. It is proximally closed by contracting the functional proximal sphincter (PS). When the ampulla contracts, its pressure increases up to the threshold. This causes the XNA to be closed and the ampulla to inject its contents into the stomach. The wider was the ampulla, the shorter the XNA was. @entity3 was detected in 20 (22%) of the 91 @entity0 with @entity1 ( @entity1 ). It was always at the level of the PS. CONCLUSION: The so-called sliding esophageal hernia is an esophageal ampulla measuring more than 2 cm in wide. The presence of the esophageal ampulla despite its size suggests that the GEJ is incompetent and @entity1 is present. @entity3 occurs at the level of the PS due to @entity1 .

title: [ XXXX as a symptom of @entity1 ].

answer: @entity3


abstract: OBJECTIVE: To determine the importance of a symptom of @entity3 . MATERIAL AND METHODS: The results of examining 95 @entity0 aged 62-92 years with the symptoms of @entity2 in the Netanya State Geriatric Center (Israel) in 1994-2004 were analyzed. Standard X-ray study of the upper digestive tract was complemented by provocation tests. The length of an X-ray-negative area (XNA) between barium in the esophagus and stomach and the width in the lower esophagus were measured. RESULTS: Only 2 (2%) of the 95 @entity0 were found to have normal function of the gastroesophageal junction (GEJ). Two @entity0 with a drastic esophageal narrowing due to @entity1 were excluded. The remaining (91) @entity0 were divided into 2 groups. The width of the esophagus was less than 2 cm and 2 cm or more in 64 (70%) and 27 (30%) @entity0 , respectively. In weak GEJ, there was esophageal dilatation above the XNA. When in a horizontal position, this portion of the esophagus evacuates its contents into the stomach as a result of ampullary function. It is proximally closed by contracting the functional proximal sphincter (PS). When the ampulla contracts, its pressure increases up to the threshold. This causes the XNA to be closed and the ampulla to inject its contents into the stomach. The wider was the ampulla, the shorter the XNA was. @entity3 was detected in 20 (22%) of the 91 @entity0 with @entity1 ( @entity1 ). It was always at the level of the PS. CONCLUSION: The so-called sliding esophageal hernia is an esophageal ampulla measuring more than 2 cm in wide. The presence of the esophageal ampulla despite its size suggests that the GEJ is incompetent and @entity1 is present. @entity3 occurs at the level of the PS due to @entity1 .

title: [ @entity3 as a symptom of XXXX ].

answer: @entity1


abstract: INTRODUCTION: Encapsulating peritoneal @entity4 is a pathological entity mainly associated with @entity2 ( @entity2 ). The clinical syndrome is characterized by various degrees of @entity3 due to thickening, @entity4 and calcification of peritoneum resulting in the encapsulation and cocooning of the bowel. It is a rare but potentially devastating complication associated with a considerable morbidity and mortality. MATERIALS AND METHODS: Cases of @entity5 ( @entity5 ), diagnosed in the Surgical Clinic of "Cantacuzino" Hospital, between 2007 and 2014 were retrospectively reviewed. During this interval, 432 surgical interventions related to @entity2 were performed: 306 peritoneal access interventions and 124 complications, of which 15 @entity0 with @entity5 . RESULTS: In all but two cases, the @entity5 diagnostic was established at the time of the surgical intervention addressed to other complication or pathology. Moreover, in 2 of the 15 @entity0 the diagnostic was established approximately 5 months after @entity2 was discontinued, and, in one of these @entity0 at the time of the extraction of the dialysis catheter. 12 of 15 @entity0 were @entity1 . Most @entity0 had a history of multiple @entity2 episodes. All the @entity0 required the passing from @entity2 to hemodialysis. There were 4 deaths (26,6%) of which one was around two months from the diagnosis. CONCLUSIONS: The timely diagnosis of the condition and the appropriate phase-specific treatment is of utmost importance in @entity5 . In advanced stages, the surgical intervention performed by a well-trained team could achieve good long-term results.

title: Encapsulating Peritoneal @entity4 - A rare and serious complication of XXXX : Case series.

answer: @entity2


abstract: INTRODUCTION: Encapsulating peritoneal @entity4 is a pathological entity mainly associated with @entity2 ( @entity2 ). The clinical syndrome is characterized by various degrees of @entity3 due to thickening, @entity4 and calcification of peritoneum resulting in the encapsulation and cocooning of the bowel. It is a rare but potentially devastating complication associated with a considerable morbidity and mortality. MATERIALS AND METHODS: Cases of @entity5 ( @entity5 ), diagnosed in the Surgical Clinic of "Cantacuzino" Hospital, between 2007 and 2014 were retrospectively reviewed. During this interval, 432 surgical interventions related to @entity2 were performed: 306 peritoneal access interventions and 124 complications, of which 15 @entity0 with @entity5 . RESULTS: In all but two cases, the @entity5 diagnostic was established at the time of the surgical intervention addressed to other complication or pathology. Moreover, in 2 of the 15 @entity0 the diagnostic was established approximately 5 months after @entity2 was discontinued, and, in one of these @entity0 at the time of the extraction of the dialysis catheter. 12 of 15 @entity0 were @entity1 . Most @entity0 had a history of multiple @entity2 episodes. All the @entity0 required the passing from @entity2 to hemodialysis. There were 4 deaths (26,6%) of which one was around two months from the diagnosis. CONCLUSIONS: The timely diagnosis of the condition and the appropriate phase-specific treatment is of utmost importance in @entity5 . In advanced stages, the surgical intervention performed by a well-trained team could achieve good long-term results.

title: Encapsulating Peritoneal XXXX - A rare and serious complication of @entity2 : Case series.

answer: @entity4


abstract: UNASSIGNED: This study aimed to compare the effect of @entity5 and @entity4 on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in @entity0 undergoing removal of four third molars. Eighteen eligible @entity0 were allocated to one of two groups to receive treatment two times a day with either @entity4 100mg or @entity5 100mg for a period of 3 days. The rescue medication intake (number) and @entity2 intensity were evaluated at 6, 12, 24, and 48h, and at 7 days postoperatively. Swelling and @entity3 opening were evaluated at 24h, 72h, and 7 days postoperatively. The peak @entity2 score occurred at 6h after surgery in the @entity5 group and at 12h in the @entity4 group. There was no statistically significant difference between the groups, although @entity2 relief was observed after 48h in the @entity5 group and after 7 days in the @entity4 group. For each group, there was a statically significant difference in @entity2 scores among the studied periods (P<0.0001). None of the @entity0 required rescue medication. There was a statistically significant difference in @entity3 opening between the preoperative and postoperative periods (P<0.0001). @entity4 and @entity5 were effective at controlling @entity2 , @entity1 , and trismus after the surgical removal of third molars.

title: Comparative efficacy of XXXX and @entity4 on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study.

answer: @entity5


abstract: UNASSIGNED: This study aimed to compare the effect of @entity5 and @entity4 on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in @entity0 undergoing removal of four third molars. Eighteen eligible @entity0 were allocated to one of two groups to receive treatment two times a day with either @entity4 100mg or @entity5 100mg for a period of 3 days. The rescue medication intake (number) and @entity2 intensity were evaluated at 6, 12, 24, and 48h, and at 7 days postoperatively. Swelling and @entity3 opening were evaluated at 24h, 72h, and 7 days postoperatively. The peak @entity2 score occurred at 6h after surgery in the @entity5 group and at 12h in the @entity4 group. There was no statistically significant difference between the groups, although @entity2 relief was observed after 48h in the @entity5 group and after 7 days in the @entity4 group. For each group, there was a statically significant difference in @entity2 scores among the studied periods (P<0.0001). None of the @entity0 required rescue medication. There was a statistically significant difference in @entity3 opening between the preoperative and postoperative periods (P<0.0001). @entity4 and @entity5 were effective at controlling @entity2 , @entity1 , and trismus after the surgical removal of third molars.

title: Comparative efficacy of @entity5 and XXXX on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study.

answer: @entity4


abstract: UNASSIGNED: Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome/ @entity5 pathway is accompanied with an increased inflammatory response and abnormal lipid accumulation in livers of aged @entity1 . To monitor the effects of aging on LPS-induced @entity0 , we administered LPS (2  mg  kg(-1) ) to young (6-month old) and aged (24-month old) @entity1 and found abnormal lipid metabolism in only aged @entity1 with increased lipid accumulation in the liver. This lipid accumulation in the liver was due to the dysregulation of @entity6 and @entity8 . We also observed severe @entity3 in aged @entity1 as indicated by increased ALT levels in serum and increased Kupffer cells in the liver. Importantly, among many @entity0 -associated factors, the aged @entity1 liver showed chronically increased @entity5 production. Increased levels of @entity5 were caused by the upregulation of @entity7 activity and inflammasome activation. In vitro studies with HepG2 cells demonstrated that treatment with @entity5 significantly induced lipid accumulation in hepatocytes through the regulation of @entity6 and @entity8 . In summary, we demonstrated that @entity2 and lipid accumulation were associated with a chronically overactive inflammasome/ @entity5 pathway in aged @entity1 livers. Based on the present findings, we propose a mechanism of aging-associated progression of @entity4 induced by endotoxin, delineating a pathogenic role of the inflammasome/ @entity5 pathway involved in lipid accumulation in the liver.

title: Age-related sensitivity to endotoxin-induced XXXX : Implication of inflammasome/ @entity5 for @entity4 .

answer: @entity3


abstract: UNASSIGNED: Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome/ @entity5 pathway is accompanied with an increased inflammatory response and abnormal lipid accumulation in livers of aged @entity1 . To monitor the effects of aging on LPS-induced @entity0 , we administered LPS (2  mg  kg(-1) ) to young (6-month old) and aged (24-month old) @entity1 and found abnormal lipid metabolism in only aged @entity1 with increased lipid accumulation in the liver. This lipid accumulation in the liver was due to the dysregulation of @entity6 and @entity8 . We also observed severe @entity3 in aged @entity1 as indicated by increased ALT levels in serum and increased Kupffer cells in the liver. Importantly, among many @entity0 -associated factors, the aged @entity1 liver showed chronically increased @entity5 production. Increased levels of @entity5 were caused by the upregulation of @entity7 activity and inflammasome activation. In vitro studies with HepG2 cells demonstrated that treatment with @entity5 significantly induced lipid accumulation in hepatocytes through the regulation of @entity6 and @entity8 . In summary, we demonstrated that @entity2 and lipid accumulation were associated with a chronically overactive inflammasome/ @entity5 pathway in aged @entity1 livers. Based on the present findings, we propose a mechanism of aging-associated progression of @entity4 induced by endotoxin, delineating a pathogenic role of the inflammasome/ @entity5 pathway involved in lipid accumulation in the liver.

title: Age-related sensitivity to endotoxin-induced @entity3 : Implication of inflammasome/ @entity5 for XXXX .

answer: @entity4


abstract: UNASSIGNED: Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome/ @entity5 pathway is accompanied with an increased inflammatory response and abnormal lipid accumulation in livers of aged @entity1 . To monitor the effects of aging on LPS-induced @entity0 , we administered LPS (2  mg  kg(-1) ) to young (6-month old) and aged (24-month old) @entity1 and found abnormal lipid metabolism in only aged @entity1 with increased lipid accumulation in the liver. This lipid accumulation in the liver was due to the dysregulation of @entity6 and @entity8 . We also observed severe @entity3 in aged @entity1 as indicated by increased ALT levels in serum and increased Kupffer cells in the liver. Importantly, among many @entity0 -associated factors, the aged @entity1 liver showed chronically increased @entity5 production. Increased levels of @entity5 were caused by the upregulation of @entity7 activity and inflammasome activation. In vitro studies with HepG2 cells demonstrated that treatment with @entity5 significantly induced lipid accumulation in hepatocytes through the regulation of @entity6 and @entity8 . In summary, we demonstrated that @entity2 and lipid accumulation were associated with a chronically overactive inflammasome/ @entity5 pathway in aged @entity1 livers. Based on the present findings, we propose a mechanism of aging-associated progression of @entity4 induced by endotoxin, delineating a pathogenic role of the inflammasome/ @entity5 pathway involved in lipid accumulation in the liver.

title: Age-related sensitivity to endotoxin-induced @entity3 : Implication of inflammasome/ XXXX for @entity4 .

answer: @entity5


abstract: The controversy surrounding the interpretation of observed increases in the high spontaneous @entity3 incidence of the B6C3F1 @entity2 after administration of certain chemical agents necessitates a mechanistic understanding into the nature of @entity1 development in this particular strain of @entity2 . Recently, @entity1 genes (oncogenes) have been detected in the DNA from a variety of @entity0 @entity1 and @entity1 cell lines. These genes have been implicated to play a role in the transformation of normal cells into cancerous ones. To investigate the role that cellular oncogenes might play in the development of spontaneous @entity3 in the B6C3F1 @entity2 , DNA was isolated from spontaneously occurring @entity3 and transfected into NIH 3T3 fibroblasts. DNA from this @entity1 tissue was capable of transforming NIH 3T3 cells from 82% of the animals examined strongly suggesting the presence of an active cellular oncogene. In contrast, DNA isolated from surrounding non-tumorous liver tissue and liver tissue from non- @entity1 bearing @entity2 did not cause any transformation in the NIH 3T3 assay. These data demonstrate that the active cellular oncogene is not present in the hepatic tissue via a germ-line transmission but is activated only in those cells of the @entity1 tissue. Experiments using Southern blot hybridization analysis have identified this active cellular oncogene to be a member of the ras oncogene family. Identification of this cellular oncogene will now allow the evaluation of factors which might modify its expression. These future studies will lead to an increased understanding of potential mechanisms by which @entity4 are enhanced and should provide more informed estimates of risk for @entity0 based on bioassay data generated in this strain of @entity2 .

title: Activation of a cellular proto-oncogene in spontaneous XXXX tissue of the B6C3F1 @entity2 .

answer: @entity3


abstract: The controversy surrounding the interpretation of observed increases in the high spontaneous @entity3 incidence of the B6C3F1 @entity2 after administration of certain chemical agents necessitates a mechanistic understanding into the nature of @entity1 development in this particular strain of @entity2 . Recently, @entity1 genes (oncogenes) have been detected in the DNA from a variety of @entity0 @entity1 and @entity1 cell lines. These genes have been implicated to play a role in the transformation of normal cells into cancerous ones. To investigate the role that cellular oncogenes might play in the development of spontaneous @entity3 in the B6C3F1 @entity2 , DNA was isolated from spontaneously occurring @entity3 and transfected into NIH 3T3 fibroblasts. DNA from this @entity1 tissue was capable of transforming NIH 3T3 cells from 82% of the animals examined strongly suggesting the presence of an active cellular oncogene. In contrast, DNA isolated from surrounding non-tumorous liver tissue and liver tissue from non- @entity1 bearing @entity2 did not cause any transformation in the NIH 3T3 assay. These data demonstrate that the active cellular oncogene is not present in the hepatic tissue via a germ-line transmission but is activated only in those cells of the @entity1 tissue. Experiments using Southern blot hybridization analysis have identified this active cellular oncogene to be a member of the ras oncogene family. Identification of this cellular oncogene will now allow the evaluation of factors which might modify its expression. These future studies will lead to an increased understanding of potential mechanisms by which @entity4 are enhanced and should provide more informed estimates of risk for @entity0 based on bioassay data generated in this strain of @entity2 .

title: Activation of a cellular proto-oncogene in spontaneous @entity3 tissue of the B6C3F1 XXXX .

answer: @entity2


abstract: BACKGROUND: Gastroesophageal reflux can cause high acidity in the esophagus and trigger heartburn and @entity0 . However, because of the esophageal mucosal barrier, the acidity at the nerve terminals of @entity0 -mediating C-fibers in esophageal mucosa is predicted to be substantially lower. We hypothesized that the esophageal dorsal root ganglia (DRG) C-fibers are activated by mild acid (compared to acidic reflux), and express receptors and ion channels highly sensitive to acid. METHODS: Extracellular single unit recordings of activity originating in esophageal DRG @entity3 nerve terminals were performed in the innervated esophagus preparation ex vivo. Acid was delivered in a manner that bypassed the esophageal mucosal barrier. The expression of mRNA for selected receptors in esophagus-specific DRG neurons was evaluated using single cell RT-PCR. KEY RESULTS: Mild acid (pH = 6.5-5.5) activated esophageal DRG C-fibers in a pH-dependent manner. The response to mild acid at pH = 6 was not affected by the @entity4 selective antagonist @entity6 . The majority (70-95%) of esophageal DRG @entity3 neurons ( @entity4 -positive) expressed mRNA for acid sensing ion channels (ASIC1a, ASIC1b, ASIC2b, and/or ASIC3), two-pore-domain (K2P) @entity2 channel TASK1, and the proton-sensing G-protein coupled receptor OGR1. Other evaluated targets (PKD2L1, TRPV4, TASK3, TALK1, @entity5 , GPR4, and TDAG8) were expressed rarely. CONCLUSIONS _ INFERENCES: @entity1 esophageal DRG C-fibers are activated by mild acid via a @entity4 -independent mechanism, and express mRNA for several receptors and ion channels highly sensitive to acid. The high acid sensitivity of esophageal C-fibers may contribute to heartburn and @entity0 in conditions of reduced mucosal barrier function.

title: Acid sensitivity of the spinal dorsal root ganglia @entity3 nociceptors innervating the XXXX esophagus.

answer: @entity1


abstract: BACKGROUND: Gastroesophageal reflux can cause high acidity in the esophagus and trigger heartburn and @entity0 . However, because of the esophageal mucosal barrier, the acidity at the nerve terminals of @entity0 -mediating C-fibers in esophageal mucosa is predicted to be substantially lower. We hypothesized that the esophageal dorsal root ganglia (DRG) C-fibers are activated by mild acid (compared to acidic reflux), and express receptors and ion channels highly sensitive to acid. METHODS: Extracellular single unit recordings of activity originating in esophageal DRG @entity3 nerve terminals were performed in the innervated esophagus preparation ex vivo. Acid was delivered in a manner that bypassed the esophageal mucosal barrier. The expression of mRNA for selected receptors in esophagus-specific DRG neurons was evaluated using single cell RT-PCR. KEY RESULTS: Mild acid (pH = 6.5-5.5) activated esophageal DRG C-fibers in a pH-dependent manner. The response to mild acid at pH = 6 was not affected by the @entity4 selective antagonist @entity6 . The majority (70-95%) of esophageal DRG @entity3 neurons ( @entity4 -positive) expressed mRNA for acid sensing ion channels (ASIC1a, ASIC1b, ASIC2b, and/or ASIC3), two-pore-domain (K2P) @entity2 channel TASK1, and the proton-sensing G-protein coupled receptor OGR1. Other evaluated targets (PKD2L1, TRPV4, TASK3, TALK1, @entity5 , GPR4, and TDAG8) were expressed rarely. CONCLUSIONS _ INFERENCES: @entity1 esophageal DRG C-fibers are activated by mild acid via a @entity4 -independent mechanism, and express mRNA for several receptors and ion channels highly sensitive to acid. The high acid sensitivity of esophageal C-fibers may contribute to heartburn and @entity0 in conditions of reduced mucosal barrier function.

title: Acid sensitivity of the spinal dorsal root ganglia XXXX nociceptors innervating the @entity1 esophagus.

answer: @entity3


abstract: To investigate the potential role of platelets in the inhibition of megakaryocytopoiesis, freeze-thawed extracts of @entity0 platelets were added to serumless liquid cultures of @entity1 marrow. When @entity4 ( @entity4 ), a marker of megakaryocytic differentiation in @entity1 , was assayed, a significant inhibition of enzymatic activity was noted in cultures containing the equivalent of greater than 5 X 10(6) solubilized platelets per milliliter. Freeze-thawed extracts of granulocytes had significantly less inhibitory effect than did platelets. @entity5 growth factor beta ( @entity2 ), a growth factor known to be inhibitory to some cell lineages and to be found at relatively high concentrations in platelets, was then added to liquid marrow cultures. A similar inhibition of @entity4 activity was detected when cultures were stimulated with mitogen-stimulated conditioned medium. The effect was potent with 50% inhibition of @entity4 activity observed at 4 pmol @entity2 /L. To determine if @entity2 inhibited specifically one aspect of megakaryocytic differentiation, the factor was added to isolated single megakaryocytes in serumless culture induced by @entity3 ( @entity3 ) to increase in size. The number of megakaryocytes increasing in size in response to @entity3 exposure was reduced from 68% to 20% when both factors were simultaneously added to cultures. Colony assays showed that megakaryocytic and granulocyte-macrophage colony detection was inhibited at picomolar concentrations of the factor. These data suggest that @entity2 is a potent in vitro inhibitor of the @entity1 megakaryocytic lineage, although its effects are not limited to this lineage.

title: Type beta transforming growth factor is a potent inhibitor of XXXX megakaryocytopoiesis in vitro.

answer: @entity1


abstract: UNASSIGNED: Road traffic @entity1 account for 1.3 million deaths per year world-wide. Mitigating both fatalities and @entity1 requires a detailed understanding of the tolerance of the @entity0 body to external load. To identify research priorities, it is necessary to periodically compare trends in injury tolerance research to the characteristics of @entity1 occurring in the field. This study sought to perform a systematic review on the last twenty years of experimental injury tolerance research, and to evaluate those results relative to available epidemiologic data. Four hundred and eight experimental injury tolerance studies from 1990-2009 were identified from a reference index of over 68,000 papers. Examined variables included the body regions, ages, and genders studied; and the experimental models used. Most (20%) of the publications studied injury to the spine. There has also been a substantial volume of biomechanical research focused on upper and lower @entity1 , @entity2 , and injury to the elderly - although these @entity1 occur with regularity in the field. In contrast, information on pediatric @entity1 (especially in the central nervous system) remains lacking. Given their frequency of injury in the field, future efforts should also include improving our understanding of tolerances and protection of vulnerable road users (e.g., motorcyclists, pedestrians).

title: The tolerance of the XXXX body to automobile collision impact - a systematic review of injury biomechanics research, 1990-2009.

answer: @entity0


abstract: BACKGROUND: Adverse left ventricular (LV) remodelling following acute @entity2 ( @entity2 ) has prognostic importance. We aimed to predict 90-day left ventricular (LV) function following acute @entity2 using variables from clinical presentation, biomarkers, and cardiovascular magnetic resonance imaging (CMR). METHODS: Consecutive @entity0 undergoing primary percutaneous coronary intervention for anterior @entity2 as part of the Selective Inhibition of Delta-protein Kinase C for the Reduction of @entity4 Size in Acute @entity2 (PROTECTION-AMI) trial were enrolled into the CMR sub-study at selected sites. CMR was performed at baseline (days 3 to 5) and 90 days and used to evaluate @entity4 size, myocardial salvage index, @entity4 heterogeneity, @entity5 and global LV function. Biochemical markers including @entity3 kinase area under the curve (CK AUC), peak CK, peak CK-myocardial band (CK-MB) and AUC, and troponin I were collected at specific time-points. RESULTS: Ninety-six @entity0 were enrolled in the CMR sub study and 85 completed the 90-day follow-up, across 24 centres worldwide. LV ejection fraction (EF) was 56% (46-63%) at baseline and 60% (49-67%) at 90 days (p<0.001). @entity4 size had moderate inverse correlation with 90-day EF (Spearman's rho=-0.7, p < 0.001) and had the strongest correlation when compared to myocardial salvage index (Spearman's rho=0.5, p=0.001), @entity4 heterogeneity (Spearman's rho=-0.4, p=0.02 or @entity5 (Spearman's rho=-0.4, p<0.001). All biochemical markers had similar moderate relationship to LVEF at 90 days (Spearman's rho -0.6 to -0.8, p=0.001). In a multivariable model, only baseline LVEF, CMR @entity4 size and @entity4 heterogeneity independently predicted 90-day LVEF. CONCLUSION: This study reports findings of a combined CMR protocol (including @entity1 imaging) in a multi-centre, multi-vendor setting. We found @entity4 size, @entity4 heterogeneity and myocardial salvage index correlated favourably with 90-day LVEF, however only the former two were independently predictive.

title: Utility of CMR Markers of XXXX in Predicting LV Functional Recovery: Results from PROTECTION AMI CMR sub-study.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: @entity1 ( @entity1 ) mostly occurs in @entity0 as a result of entrapment of the leg in the bicycle spokes. No guideline or protocol exists that defines what type of radiography is indicated to diagnose or rule out a @entity2 commonly associated with these injuries. The aim of this study was (1) to evaluate the type of radiographs that are obtained in @entity0 with @entity1 , (2) to assess in which anatomical regions @entity2 occur and (3) to evaluate on which radiographs a @entity2 can be detected in @entity0 with @entity1 . @entity0 AND METHODS: A retrospective cohort study was performed in paediatric @entity0 presenting at the Emergency Department (ED) of a university hospital with a paediatric surgery department between June 2008 and December 2013. RESULTS: In 99 of the 320 @entity0 (31.4%) evaluated with radiography following @entity1 a @entity2 was diagnosed. In almost two third of the @entity0 (63%) radiographic imaging of two or more anatomical regions was performed. In 98 @entity0 (99%) the @entity2 was located at the distal tibia or fibula. All @entity2 were diagnosed on a radiograph of the ankle or lower leg (including the ankle region). No @entity2 of the foot were diagnosed. CONCLUSION: We suggest that in @entity0 with a clinical suspicion of a @entity2 at the ankle region, in which no @entity2 is seen at the radiograph of the ankle, no additional radiographs are necessary.

title: Plain radiography in @entity0 with spoke XXXX : A retrospective cohort study.

answer: @entity1


abstract: BACKGROUND AND PURPOSE: @entity1 ( @entity1 ) mostly occurs in @entity0 as a result of entrapment of the leg in the bicycle spokes. No guideline or protocol exists that defines what type of radiography is indicated to diagnose or rule out a @entity2 commonly associated with these injuries. The aim of this study was (1) to evaluate the type of radiographs that are obtained in @entity0 with @entity1 , (2) to assess in which anatomical regions @entity2 occur and (3) to evaluate on which radiographs a @entity2 can be detected in @entity0 with @entity1 . @entity0 AND METHODS: A retrospective cohort study was performed in paediatric @entity0 presenting at the Emergency Department (ED) of a university hospital with a paediatric surgery department between June 2008 and December 2013. RESULTS: In 99 of the 320 @entity0 (31.4%) evaluated with radiography following @entity1 a @entity2 was diagnosed. In almost two third of the @entity0 (63%) radiographic imaging of two or more anatomical regions was performed. In 98 @entity0 (99%) the @entity2 was located at the distal tibia or fibula. All @entity2 were diagnosed on a radiograph of the ankle or lower leg (including the ankle region). No @entity2 of the foot were diagnosed. CONCLUSION: We suggest that in @entity0 with a clinical suspicion of a @entity2 at the ankle region, in which no @entity2 is seen at the radiograph of the ankle, no additional radiographs are necessary.

title: Plain radiography in XXXX with spoke @entity1 : A retrospective cohort study.

answer: @entity0


abstract: BACKGROUND: Our previous work on the association between maternal @entity1 and @entity2 was based on cohorts formed by @entity0 with public drug insurance, i.e., over-represented by @entity0 with lower socioeconomic status, questioning the generalizability of our findings. This study aimed to evaluate whether or not drug insurance status, as a proxy of socioeconomic status, is an effect modifier for the association between maternal @entity1 and major @entity2 . METHODS: A cohort of 36,587 pregnancies from @entity3 @entity0 and 198,935 pregnancies from nonasthmatic @entity0 selected independently of their drug insurance status was reconstructed with Qu  bec administrative databases (1998-2009). Asthmatic @entity0 were identified using a validated case definition of @entity1 . Cases of major @entity2 were identified using diagnostic codes recorded in the hospitalization database. Drug insurance status at the beginning of pregnancy was classified into three groups: publicly insured with social welfare, publicly insured without social welfare, and privately insured. Adjusted odds ratios were estimated with generalized estimation equations, including an interaction term between maternal @entity1 and drug insurance status. RESULTS: The prevalence of @entity2 was 6.8% among @entity3 @entity0 and 5.8% among nonasthmatics. The impact of @entity1 on the prevalence of @entity2 was significantly greater in @entity0 publicly insured with social welfare (odds ratio   =   1.42; 95% confidence interval, 1.25-1.61) than in the other two groups ([odds ratio   =   1.10; 1.00-1.21] in the publicly insured without social welfare and [odds ratio   =   1.13; 1.07-1.20] in the privately insured group). CONCLUSION: The increased risk of major @entity2 associated with @entity1 was significantly higher among pregnant @entity0 publicly insured with social welfare than among those privately insured. As a result of this effect modification by drug insurance status, findings from Qu  bec observational studies using databases mainly formed of @entity0 publicly insured with social welfare may not be generalized to the entire population.

title: Is drug insurance status an effect modifier in epidemiologic database studies? The case of maternal @entity1 and major XXXX .

answer: @entity2


abstract: BACKGROUND: Our previous work on the association between maternal @entity1 and @entity2 was based on cohorts formed by @entity0 with public drug insurance, i.e., over-represented by @entity0 with lower socioeconomic status, questioning the generalizability of our findings. This study aimed to evaluate whether or not drug insurance status, as a proxy of socioeconomic status, is an effect modifier for the association between maternal @entity1 and major @entity2 . METHODS: A cohort of 36,587 pregnancies from @entity3 @entity0 and 198,935 pregnancies from nonasthmatic @entity0 selected independently of their drug insurance status was reconstructed with Qu  bec administrative databases (1998-2009). Asthmatic @entity0 were identified using a validated case definition of @entity1 . Cases of major @entity2 were identified using diagnostic codes recorded in the hospitalization database. Drug insurance status at the beginning of pregnancy was classified into three groups: publicly insured with social welfare, publicly insured without social welfare, and privately insured. Adjusted odds ratios were estimated with generalized estimation equations, including an interaction term between maternal @entity1 and drug insurance status. RESULTS: The prevalence of @entity2 was 6.8% among @entity3 @entity0 and 5.8% among nonasthmatics. The impact of @entity1 on the prevalence of @entity2 was significantly greater in @entity0 publicly insured with social welfare (odds ratio   =   1.42; 95% confidence interval, 1.25-1.61) than in the other two groups ([odds ratio   =   1.10; 1.00-1.21] in the publicly insured without social welfare and [odds ratio   =   1.13; 1.07-1.20] in the privately insured group). CONCLUSION: The increased risk of major @entity2 associated with @entity1 was significantly higher among pregnant @entity0 publicly insured with social welfare than among those privately insured. As a result of this effect modification by drug insurance status, findings from Qu  bec observational studies using databases mainly formed of @entity0 publicly insured with social welfare may not be generalized to the entire population.

title: Is drug insurance status an effect modifier in epidemiologic database studies? The case of maternal XXXX and major @entity2 .

answer: @entity1


abstract: PURPOSE: Diagnosing @entity5 is challenging because of varied clinical presentation, nonspecific neuroimaging features, and rare confirmation of causality. We reviewed acute neuroimaging of @entity0 with clinically suspected @entity1 to identify findings that may correlate with etiology and length of stay. METHODS: Imaging of 141 @entity0 with clinically suspected @entity1 as part of The @entity6 Project from 2005 to 2012 at a single institution was reviewed to compare the extent of @entity3 to @entity0 age, gender, length of stay, and unknown, possible, or confirmed pathogen. Scan review was blinded and categorized by extent and distribution of abnormal findings. RESULTS: Abnormal findings were evident on 23% (22/94) of computed tomography and 50% (67/134) of magnetic resonance imaging studies in the acute setting. Twenty @entity0 with normal admission computed tomography had abnormal findings on magnetic resonance imaging performed within 2  days. Length of stay was significantly longer among @entity0 with abnormal acute magnetic resonance imaging (P  <  0.001) and correlated with increased complexity (Spearman rho  =  0.4, P  <  0.001) categorized as: no imaging abnormality, meningeal enhancement and/or focal nonenhancing lesion, multifocal lesions, confluent lesions, and lesions plus diffusion restriction, @entity2 , or @entity4 . There was no correlation between neuroimaging findings and an identifiable pathogen (P  =  0.8). CONCLUSION: Abnormal magnetic resonance imaging findings are more common than abnormal computed tomography findings in @entity5 . Increasing complexity of magnetic resonance imaging findings correlated with disease severity as evidenced by longer length of stay, but were not specific for an identifiable pathogen using a standardized diagnostic @entity1 panel.

title: Acute @entity5 neuroimaging: single-institution series as part of the XXXX project.

answer: @entity6


abstract: PURPOSE: Diagnosing @entity5 is challenging because of varied clinical presentation, nonspecific neuroimaging features, and rare confirmation of causality. We reviewed acute neuroimaging of @entity0 with clinically suspected @entity1 to identify findings that may correlate with etiology and length of stay. METHODS: Imaging of 141 @entity0 with clinically suspected @entity1 as part of The @entity6 Project from 2005 to 2012 at a single institution was reviewed to compare the extent of @entity3 to @entity0 age, gender, length of stay, and unknown, possible, or confirmed pathogen. Scan review was blinded and categorized by extent and distribution of abnormal findings. RESULTS: Abnormal findings were evident on 23% (22/94) of computed tomography and 50% (67/134) of magnetic resonance imaging studies in the acute setting. Twenty @entity0 with normal admission computed tomography had abnormal findings on magnetic resonance imaging performed within 2  days. Length of stay was significantly longer among @entity0 with abnormal acute magnetic resonance imaging (P  <  0.001) and correlated with increased complexity (Spearman rho  =  0.4, P  <  0.001) categorized as: no imaging abnormality, meningeal enhancement and/or focal nonenhancing lesion, multifocal lesions, confluent lesions, and lesions plus diffusion restriction, @entity2 , or @entity4 . There was no correlation between neuroimaging findings and an identifiable pathogen (P  =  0.8). CONCLUSION: Abnormal magnetic resonance imaging findings are more common than abnormal computed tomography findings in @entity5 . Increasing complexity of magnetic resonance imaging findings correlated with disease severity as evidenced by longer length of stay, but were not specific for an identifiable pathogen using a standardized diagnostic @entity1 panel.

title: Acute XXXX neuroimaging: single-institution series as part of the @entity6 project.

answer: @entity5


abstract: OBJECTIVE: The aim of the present study was to evaluate the use of @entity0 epididymis protein 4 ( @entity3 ) and @entity1 antigen 125 (CA 125) biomarkers in differential diagnosis of @entity1 in a population of Czech @entity0 . DESIGN: Prospective study. SETTING: Department of Gynaecology and Obstetrics, Faculty of Medicine at Masaryk University and Faculty Hospital in Brno. METHODS: Our prospective study includes 115 @entity0 with @entity4 and 106 @entity0 with @entity1 in the control group. They were diagnosed with endometrial biopsy in the period from 7/2010 to 6/2013. The @entity0 with @entity1 underwent definitive surgical treatment to determine the stage of disease. The median and ranges of serum levels were determined in relation to the histological result (benign vs @entity1 ). Statistical analysis operates with logarithm values of markers because their distribution is not normal and uses logistic regression. RESULTS: While analysing two groups of @entity0 with different histology, there was demonstrated a statistically significant difference (p < 0.05), only in @entity3 , by cut-off 48,5 pmol/l there was achieved sensitivity of 87.8%, specificity of 56.6% and negative predictive value of 81.1%.Coclusion: Diagnostic benefit of @entity3 can be considered especially in @entity0 with increased risk of @entity2 and in @entity0 with serious internal co-morbidities. @entity3 could help in combination with clinical and ultrasound finding in the differentiation of prognostically various groups of @entity0 and in decision-making in relation to the individualization of the treatment plan. However, the optimal cut-off for @entity3 has not been solved yet, and to do so, it will require more research with larger studies and their comparative analysis..

title: [The importance of XXXX in differential diagnosis of @entity2 ].

answer: @entity3


abstract: OBJECTIVE: The aim of the present study was to evaluate the use of @entity0 epididymis protein 4 ( @entity3 ) and @entity1 antigen 125 (CA 125) biomarkers in differential diagnosis of @entity1 in a population of Czech @entity0 . DESIGN: Prospective study. SETTING: Department of Gynaecology and Obstetrics, Faculty of Medicine at Masaryk University and Faculty Hospital in Brno. METHODS: Our prospective study includes 115 @entity0 with @entity4 and 106 @entity0 with @entity1 in the control group. They were diagnosed with endometrial biopsy in the period from 7/2010 to 6/2013. The @entity0 with @entity1 underwent definitive surgical treatment to determine the stage of disease. The median and ranges of serum levels were determined in relation to the histological result (benign vs @entity1 ). Statistical analysis operates with logarithm values of markers because their distribution is not normal and uses logistic regression. RESULTS: While analysing two groups of @entity0 with different histology, there was demonstrated a statistically significant difference (p < 0.05), only in @entity3 , by cut-off 48,5 pmol/l there was achieved sensitivity of 87.8%, specificity of 56.6% and negative predictive value of 81.1%.Coclusion: Diagnostic benefit of @entity3 can be considered especially in @entity0 with increased risk of @entity2 and in @entity0 with serious internal co-morbidities. @entity3 could help in combination with clinical and ultrasound finding in the differentiation of prognostically various groups of @entity0 and in decision-making in relation to the individualization of the treatment plan. However, the optimal cut-off for @entity3 has not been solved yet, and to do so, it will require more research with larger studies and their comparative analysis..

title: [The importance of @entity3 in differential diagnosis of XXXX ].

answer: @entity2


abstract: OBJECTIVES: To clarify the relationship between facility-level mammography interpretive volume and @entity0 screening outcomes. METHODS: We calculated annual mammography interpretive volumes from 2000-2009 for 116 facilities participating in the U.S. @entity0 Surveillance Consortium (BCSC). Radiology, pathology, @entity2 registry, and @entity1 's self-report information were used to determine the indication for each exam, @entity2 characteristics, and @entity1 characteristics. We examined the effect of annual total volume and percentage of mammograms that were screening on @entity2 detection rates using multinomial logistic regression adjusting for age, race/ethnicity, time since last mammogram, and BCSC registries. "Good prognosis" @entity2 were defined as screen-detected invasive @entity2 that were <15   mm, early stage, and lymph node negative at diagnosis. RESULTS: From 3,098,481 screening mammograms, 9,899 @entity2 were screen-detected within one year of the exam. Approximately 80% of facilities had annual total interpretive volumes of >2,000 mammograms, and 42% had >5,000. Higher total volume facilities were significantly more likely to diagnose invasive @entity2 with good prognoses (odds ratio [OR] 1.32; 95% confidence interval [CI] 1.10-1.60, for total volume of 5,000-10,000/year v. 1,000-2,000/year; p-for-trend <0.001). A concomitant decrease in @entity2 with poor prognosis was seen (OR 0.78; 95%CI 0.63-0.98 for total volume of 5,000-10,000/year v. 1,000-2,000/year). CONCLUSIONS: Mammography facilities with higher total interpretive volumes detected more good prognosis invasive @entity2 and fewer poor prognosis invasive @entity2 , suggesting that @entity1 attending these facilities may be more likely to benefit from screening.

title: Facility Mammography Volume in Relation to XXXX Screening Outcomes.

answer: @entity0


abstract: PURPOSE: Two potential mechanisms leading to postural and osseous @entity0 after @entity5 are @entity1 between functioning internal @entity2 and paralyzed external @entity2 and @entity3 of paralyzed muscles. Our goal was to evaluate the combined and isolated effects of these 2 mechanisms on transverse plane shoulder forces using a computational model of @entity6 @entity4 . METHODS: We modeled a @entity6 injury using a computational musculoskeletal upper limb model. Muscles expected to be denervated by @entity6 injury were classified as affected, with the remaining shoulder muscles classified as unaffected. To model @entity1 , affected muscles were given no resting tone whereas unaffected muscles were given resting tone at 30% of maximal activation. To model impaired growth, affected muscles were reduced in length by 30% compared with normal whereas unaffected muscles remained normal in length. Four scenarios were simulated: normal, @entity1 only, impaired growth only, and both @entity1 and impaired growth. Passive shoulder rotation range of motion and glenohumeral joint reaction forces were evaluated to assess postural and @entity0 . RESULTS: All impaired scenarios exhibited restricted range of motion and increased and posteriorly directed compressive glenohumeral joint forces. Individually, @entity1 caused worse restriction in range of motion and higher and more posteriorly directed glenohumeral forces than did @entity1 . Combined @entity1 and impaired growth caused the most restricted joint range of motion and the highest joint reaction force of all scenarios. CONCLUSIONS: Both @entity1 and @entity3 contributed to range of motion and force changes consistent with clinically observed deformity, although the most substantial effects resulted from @entity1 . CLINICAL RELEVANCE: Simulations suggest that treatment strategies emphasizing treatment of @entity3 are warranted for @entity0 after @entity5 .

title: Contributions of Muscle Imbalance and Impaired Growth to Postural and Osseous XXXX Following Brachial Plexus Birth Palsy: A  Computational Simulation Analysis.

answer: @entity0