abstract: Objective. The objective is to observe whether the traditional Chinese medicine (TCM) Nao-Xue-Shu oral liquid improves @entity2 of mixed @entity1 . Methods. A total of 102 @entity0 with @entity2 of mixed @entity1 were divided into two groups by a single blind random method. The @entity0 treated by standard Western medicine plus Nao-Xue-Shu oral liquid (n = 58) were assigned to the treatment group while the remaining @entity0 treated only by standard Western medicine (n = 58) constituted the control group. Changes in the @entity2 ( @entity2 ), Modified Rankin Scale (mRS), National Institutes of Health @entity1 Scale (NIHSS), and hemorheology parameters were assessed to evaluate the effects of the treatments. Results. Excluding the @entity0 who dropped out, 54 @entity0 in the treatment group and 51 @entity0 in the control group were used to evaluate the effects. Significant and persistent improvements in the @entity2 score, specifically comprehension, repetition, naming, and calculating, were found in the treatment group when the effects were evaluated at the end of week 2 and week 4, respectively, compared with baseline. The naming and writing scores were also improved at the end of week 4 in this group. The comprehension and reading scores were improved at the end of week 4 in the control group compared with the baseline, but the improvements were smaller than those in the treatment group. The percentages of @entity0 at the 0-1 range of mRS were increased at the end of week 2 and week 4 in both groups, but the improvements in the treatment group were much larger than those in the control group. Greater improvements in the NIHSS scores and the hemorheology parameters in the treatment group were also observed compared with the control group at the end of week 2 and week 4. Conclusion. Nao-Xue-Shu oral liquid formulation improved @entity2 in mixed @entity1 @entity0 and thus might be a potentially effective drug for treating @entity1 .

title: Nao-Xue-Shu Oral Liquid Improves Aphasia of Mixed XXXX .

answer: @entity1


abstract: INTRODUCTION: The clinical effect of oral serum-derived @entity4 immunoglobulin/protein isolate (SBI) on symptom and disease management in @entity0 with @entity1 ( @entity1 ) is reported in this retrospective case series. METHODS: A single-center, retrospective chart review of @entity1 @entity0 [N = 45; @entity2 ( @entity2 ), n = 38 and @entity3 ( @entity3 ), n = 7] with limited to no response to traditional pharmaceutical therapies in controlling symptoms was performed after providing SBI (5 g/day) for nutritional support. @entity0 were contacted at least monthly to assess response to SBI for symptom management measured by a Likert scale (0 = none; 1 = minimal; 2 = moderate; 3 = significant; 4 = complete). Analysis of variance (ANOVA) was performed on response to therapy based on @entity0 characteristics (age, gender, race) and @entity1 diagnosis. A multivariate ordered logistical regression model was performed to determine the odds ratio in overall disease management between week 1 and week 12. Finally, the overall group response and percent improvement to SBI was determined over 12 weeks. RESULTS: The odds ratio from the regression model demonstrated that @entity1 @entity0 were 2.8 times more likely to report clinical improvement in symptom scores with the addition of SBI to their therapeutic regimens [95% confidence interval (CI) 1.266-6.016, p = 0.011]. Disease management was not significantly associated with age, gender, race or disease state. The percentage of @entity0 reporting a response to SBI therapy at week 1 was 49% which increased to 76% after 12 weeks with the fraction of responders gaining significant symptom improvement doubling during the same time period (9% versus 20%). Overall, this group of @entity1 @entity0 showed increased, steady response to SBI therapy between week 1 and 12 with no reported side effects. CONCLUSION: These results suggest that SBI improves clinical management of @entity1 @entity0 who are not fully managed on traditional therapies. SBI should be considered for the nutritional support of @entity1 regardless of disease activity, location, phenotype, duration, or complexity.

title: @entity1 with oral serum-derived XXXX immunoglobulin.

answer: @entity4


abstract: INTRODUCTION: The clinical effect of oral serum-derived @entity4 immunoglobulin/protein isolate (SBI) on symptom and disease management in @entity0 with @entity1 ( @entity1 ) is reported in this retrospective case series. METHODS: A single-center, retrospective chart review of @entity1 @entity0 [N = 45; @entity2 ( @entity2 ), n = 38 and @entity3 ( @entity3 ), n = 7] with limited to no response to traditional pharmaceutical therapies in controlling symptoms was performed after providing SBI (5 g/day) for nutritional support. @entity0 were contacted at least monthly to assess response to SBI for symptom management measured by a Likert scale (0 = none; 1 = minimal; 2 = moderate; 3 = significant; 4 = complete). Analysis of variance (ANOVA) was performed on response to therapy based on @entity0 characteristics (age, gender, race) and @entity1 diagnosis. A multivariate ordered logistical regression model was performed to determine the odds ratio in overall disease management between week 1 and week 12. Finally, the overall group response and percent improvement to SBI was determined over 12 weeks. RESULTS: The odds ratio from the regression model demonstrated that @entity1 @entity0 were 2.8 times more likely to report clinical improvement in symptom scores with the addition of SBI to their therapeutic regimens [95% confidence interval (CI) 1.266-6.016, p = 0.011]. Disease management was not significantly associated with age, gender, race or disease state. The percentage of @entity0 reporting a response to SBI therapy at week 1 was 49% which increased to 76% after 12 weeks with the fraction of responders gaining significant symptom improvement doubling during the same time period (9% versus 20%). Overall, this group of @entity1 @entity0 showed increased, steady response to SBI therapy between week 1 and 12 with no reported side effects. CONCLUSION: These results suggest that SBI improves clinical management of @entity1 @entity0 who are not fully managed on traditional therapies. SBI should be considered for the nutritional support of @entity1 regardless of disease activity, location, phenotype, duration, or complexity.

title: XXXX with oral serum-derived @entity4 immunoglobulin.

answer: @entity1


abstract: BACKGROUND: It has been reported that the @entity3 sensing receptor ( @entity4 ), a widely expressed G protein-coupled receptor, can stimulate cell differentiation and proliferation. However, in @entity2 , loss of @entity4 expression has been associated with tumorigenesis, @entity1 , and progression. Recent studies have indicated that the @entity4 could promote the expression of @entity6 , which was considered a @entity2 suppressor. However, in @entity0 @entity5 , the importance of the @entity4 and @entity6 has not been sufficiently investigated. METHODS: Expression levels of @entity4 and @entity6 in paraffin sections from 117 resected @entity5 @entity0 were evaluated by immunohistochemistry. We analyzed the correlation between our target proteins and clinical variables. Clinical significance was analyzed by multivariate Cox regression analysis, Kaplan-Meier curve, and log-rank test. RESULTS: Expression of the @entity4 in @entity5 tissue was significantly lower than in the normal sample (P = 0.003). Kendall tau-b analysis showed that, in a @entity5 sample, the expression of @entity4 positively correlated with a high level of @entity6 (P < 0.001). @entity5 @entity0 with a strong expression of @entity4 (P = 0.034) or @entity6 (P = 0.001) had longer overall survival. Multivariate Cox proportional hazards model analysis showed that the combined marker was an independent prognostic indicator of overall survival (hazard ratio = 0.440, confidence interval = 0.249-0.779, P = 0.005). CONCLUSIONS: We identified the @entity4 as a new prognostic biomarker in @entity5 . These results also suggested that the @entity4 may become a new therapeutic @entity5 .

title: Expression of XXXX sensing receptor and @entity6 correlated with @entity5 .

answer: @entity3


abstract: BACKGROUND: It has been reported that the @entity3 sensing receptor ( @entity4 ), a widely expressed G protein-coupled receptor, can stimulate cell differentiation and proliferation. However, in @entity2 , loss of @entity4 expression has been associated with tumorigenesis, @entity1 , and progression. Recent studies have indicated that the @entity4 could promote the expression of @entity6 , which was considered a @entity2 suppressor. However, in @entity0 @entity5 , the importance of the @entity4 and @entity6 has not been sufficiently investigated. METHODS: Expression levels of @entity4 and @entity6 in paraffin sections from 117 resected @entity5 @entity0 were evaluated by immunohistochemistry. We analyzed the correlation between our target proteins and clinical variables. Clinical significance was analyzed by multivariate Cox regression analysis, Kaplan-Meier curve, and log-rank test. RESULTS: Expression of the @entity4 in @entity5 tissue was significantly lower than in the normal sample (P = 0.003). Kendall tau-b analysis showed that, in a @entity5 sample, the expression of @entity4 positively correlated with a high level of @entity6 (P < 0.001). @entity5 @entity0 with a strong expression of @entity4 (P = 0.034) or @entity6 (P = 0.001) had longer overall survival. Multivariate Cox proportional hazards model analysis showed that the combined marker was an independent prognostic indicator of overall survival (hazard ratio = 0.440, confidence interval = 0.249-0.779, P = 0.005). CONCLUSIONS: We identified the @entity4 as a new prognostic biomarker in @entity5 . These results also suggested that the @entity4 may become a new therapeutic @entity5 .

title: Expression of @entity3 sensing receptor and @entity6 correlated with XXXX .

answer: @entity5


abstract: BACKGROUND: It has been reported that the @entity3 sensing receptor ( @entity4 ), a widely expressed G protein-coupled receptor, can stimulate cell differentiation and proliferation. However, in @entity2 , loss of @entity4 expression has been associated with tumorigenesis, @entity1 , and progression. Recent studies have indicated that the @entity4 could promote the expression of @entity6 , which was considered a @entity2 suppressor. However, in @entity0 @entity5 , the importance of the @entity4 and @entity6 has not been sufficiently investigated. METHODS: Expression levels of @entity4 and @entity6 in paraffin sections from 117 resected @entity5 @entity0 were evaluated by immunohistochemistry. We analyzed the correlation between our target proteins and clinical variables. Clinical significance was analyzed by multivariate Cox regression analysis, Kaplan-Meier curve, and log-rank test. RESULTS: Expression of the @entity4 in @entity5 tissue was significantly lower than in the normal sample (P = 0.003). Kendall tau-b analysis showed that, in a @entity5 sample, the expression of @entity4 positively correlated with a high level of @entity6 (P < 0.001). @entity5 @entity0 with a strong expression of @entity4 (P = 0.034) or @entity6 (P = 0.001) had longer overall survival. Multivariate Cox proportional hazards model analysis showed that the combined marker was an independent prognostic indicator of overall survival (hazard ratio = 0.440, confidence interval = 0.249-0.779, P = 0.005). CONCLUSIONS: We identified the @entity4 as a new prognostic biomarker in @entity5 . These results also suggested that the @entity4 may become a new therapeutic @entity5 .

title: Expression of @entity3 sensing receptor and XXXX correlated with @entity5 .

answer: @entity6


abstract: INTRODUCTION: Prolapse of the rectum is the herniation of the rectum through the anus, which may be categorised as mucosal or complete. AIM: To evaluate the clinical manifestation, treatment, and surgical complications of @entity0 with @entity1 over a 6-year period. MATERIAL AND METHODS: This study was carried out on @entity0 aged < 14 years who were admitted or referred for @entity1 that failed to respond after medical treatment in Imam Khomeini and Abouzar @entity0 's Hospital. Duration of the study was 6 years starting in March 2002. These cases were referred after failure of medical and conservative treatment. Age, sex, clinical manifestation, and type of procedure were recorded. Analysis was done using SPSS version 11.0 (SPSS Inc, Chicago, IL, USA). The   (2) test was used for comparison. RESULTS: Seventy-one cases were included in this study. Of these cases, 50 (70.4%) were male and 21 (29.6%) were female (p < 0.0001). Mean age of cases was 4.97   3.42 years (range: 2 days to 13 years). Of the male cases, 38% were in the age range of 3-6 years. In female cases, 57.1% were in the range of 1.5-3 years. Of all 71 cases, injection sclerotherapy was done for 50 (70.43%) for the first time. Twenty-one cases had history of injection sclerotherapy and 16 (22.53%) were treated by perineal surgery, and 5 (7.04%) had abdominal surgery. One case experienced recurrent @entity1 (1.40%) following injection sclerotherapy. CONCLUSIONS: In @entity0 , more than half of the cases were in the age range 1.5-3 years. Among male cases, 38% were in the age range of 1.5-3 years. The results of treatment of @entity1 in our hospitals was similar to that seen in developed countries.

title: Rectal prolapse in XXXX : a study of 71 cases.

answer: @entity0


abstract: The intercellular homotypic adhesive properties of 14 clones derived from a nontumorigenic @entity0 liver epithelial cell line (LEC), derived from neonatal Fischer @entity0 , were examined and compared to those of the @entity1 H4-II-E cell line. Each clone was assayed also for the degree of chromosomal @entity2 and the ability to grow in soft agar. Over 100-fold differences in adhesive properties were observed among the clones, but no correlation was observed between the degree of @entity2 in the clones and intercellular adhesive properties. The parent LEC cell line and the clones derived from it were unable to grow in soft agar. The H4-II-E cells showed negligible capacity to reaggregate after dissociation into single cells and these cells readily formed colonies in soft agar. Many of the LEC clones were similar to the H4-II-E cells in their adhesive properties, which suggests that reduced cell-to-cell adhesiveness per se is not a necessary prerequisite of epithelial cells to be able to grow independent of anchorage. Two-dimensional @entity3 gel electrophoresis (2D-PAGE) of concanavalin A (Con A)-binding glycoproteins in the "most adhesive" clone 67 and the "least adhesive" clone 201 showed markedly elevated amounts of acidic 105 and 67-kDa glycoproteins in clone 67. Proteins with similar migration patterns in 2D-PAGE have previously been reported to participate in specific homotypic intercellular adhesion of liver cells. The Con A-binding glycoprotein pattern in H4-II-E cells was markedly different from that of LEC cells with a set of six proteins missing and nine proteins appearing new in the H4-II-E cells. It is suggested that, in addition to identifying known epithelial cell polypeptides, systematic screening of cell surface-associated glycoproteins in normal and transformed epithelial cells in vitro and in vivo may lead to identification of novel polypeptides intimately associated with the transformed phenotype.

title: Heterogeneity of intercellular adhesion in XXXX liver cells in culture.

answer: @entity0


abstract: BACKGROUND: Despite the growing numbers of @entity0 and @entity0 with @entity3 in Canada, sex-specific issues in treatment have not been re-examined in the current population of @entity0 with @entity3 . We aimed to evaluate sex differences in substance use, health, and social functioning among @entity0 and @entity0 currently receiving @entity2 treatment for @entity3 in Ontario, Canada. METHODS: We recruited 503 @entity0 with @entity3 receiving @entity2 maintenance treatment. We collected data on demographics, treatment characteristics, @entity1 history, addiction severity, and drug use patterns through urinalysis. We performed adjusted univariate analyses and logistic regression to identify distinct factors affecting @entity0 and @entity0 . RESULTS: Among our sample of 54  % (n   =   266) @entity0 and 46  % @entity0 (n   =   226) with mean age 38.3  years, less than half of @entity0 were employed (35.6  %) and married (31.8  %) and had completed a high school education (27.9  %). Compared to @entity0 , @entity0 had frequent physical and psychological health problems, family history of @entity1 , and childcare responsibilities and began using opioids through a physician prescription. @entity0 had higher rates of employment, cigarette smoking, and @entity4 use compared to @entity0 . CONCLUSIONS: Our results have revealed different patterns of substance use, health, and social functioning among @entity0 and @entity0 currently receiving @entity2 treatment for @entity3 in Ontario, Canada. This information can be used to develop an integrative treatment regimen that caters to the individual needs of @entity0 and @entity0 , as well as to inform @entity2 treatment protocols to include specialized services (including vocational counseling, childcare and parenting assistance, medical assistance, relationship or domestic violence counseling, etc.) and increase their availability and accessibility on a larger scale.

title: Sex differences in substance use, health, and social functioning among opioid users receiving XXXX treatment: a multicenter cohort study.

answer: @entity2


abstract: Junctional @entity1 (JET) is a life-threatening @entity2 frequently seen after surgical correction of @entity4 . This study evaluates the use of a modified, commercially available temporary dual chamber pacemaker used to reestablish AV synchrony by R wave synchronized atrial pacing, a technique not routinely applied because of a lack of appropriate equipment. Ten consecutive @entity0 with postoperative JET (median maximum heart rate 185, range 130-240 beats/min) age 0.3-45 (median 5.2) months were studied. R wave synchronized atrial pacing was performed using the VAT mode with inverse connection of the pacing wires (effectively AVT mode), short postventricular atrial refractory period (100 ms), and long AV (effectively VA) delay. AV delay was adjusted to achieve maximum increase in arterial pressure by optimal AV resynchronization. Pacing was successfully applied in all @entity0 for a median period of 29 (range 10-96) hours until @entity1 cessation and led to an immediate increase in systolic, mean, and pulse pressure by 8.9 +/- 3.2 (P < 0.001), 8.1 +/- 4.0 (P < 0.001), and 11.9 +/- 7.8% (P < 0.005), respectively. Two @entity0 developed pacemaker-mediated @entity1 , which could be easily stopped by AV (effectively VA) delay prolongation. @entity3 was induced in one @entity0 by asynchronous atrial pacing during the VAT (effectively AVT) mode and managed by overdrive pacing. In conclusion, R wave synchronized atrial pacing could be easily performed using a modified, commercially available temporary dual chamber pacemaker. Significant hemodynamic benefit was achieved due to optimal AV resynchronization at intrinsic heart rate and spontaneous ventricular activation sequence. R wave synchronized atrial pacing should be included in the standard management protocol of postoperative JET.

title: Use of a modified, commercially available temporary pacemaker for R wave synchronized atrial pacing in postoperative junctional XXXX .

answer: @entity1


abstract: AIM: To look at the relationship between @entity7 ( @entity7 ) and food @entity8 in adults. METHODS: We retrospectively analysed medical records of 100 consecutive @entity0 who presented to our hospital with oesophageal food @entity9 (FBO) between 2012 and 2014. In this cohort, 96 were adults (64% male), and 4 paediatric @entity0 were excluded from the analysis as our centre did not have paediatric gastroenterologists. Eighty-five adult @entity0 underwent emergency gastroscopy. The food bolus was either advanced into the stomach using the push technique or retrieved using a standard retrieval net. Biopsies were obtained in 51 @entity0 from the proximal and distal parts of the oesophagus at initial gastroscopy. All biopsy specimens were assessed and reviewed by dedicated gastrointestinal pathologists at the Department of Pathology, University Hospital Geelong. The diagnosis of @entity7 was defined and established by the presence of the following histological features: (1) peak eosinophil counts > 20/hpf; (2) eosinophil microabscess; (3) superficial layering of eosinophils; (4) extracellular eosinophil granules; (5) @entity6 ; (6) dilated intercellular spaces; and (7) subepithelial or lamina propria @entity1 . The histology results of the biopsy specimens were accessed from the pathology database of the hospital and recorded for analysis. RESULTS: Our cohort had a median age of 60. Seventeen/51 (33%) @entity0 had evidence of @entity7 on biopsy findings. The majority of @entity0 with @entity7 were male (71%). Classical endoscopic features of oesophageal rings, furrows or white plaques and exudates were found in 59% of @entity0 with @entity7 . Previous episodes of FBO were present in 12/17 @entity0 and 41% had a history of @entity4 , hay @entity2 or @entity5 . @entity3 and benign strictures were found in 20/34 @entity0 who did not have biopsies. CONCLUSION: @entity7 is present in approximately one third of @entity0 who are admitted with FBO. Biopsies should be performed routinely at index endoscopy in order to pursue this treatable cause of long term morbidity.

title: Prevalence of @entity7 in adults presenting with oesophageal food XXXX .

answer: @entity9


abstract: AIM: To look at the relationship between @entity7 ( @entity7 ) and food @entity8 in adults. METHODS: We retrospectively analysed medical records of 100 consecutive @entity0 who presented to our hospital with oesophageal food @entity9 (FBO) between 2012 and 2014. In this cohort, 96 were adults (64% male), and 4 paediatric @entity0 were excluded from the analysis as our centre did not have paediatric gastroenterologists. Eighty-five adult @entity0 underwent emergency gastroscopy. The food bolus was either advanced into the stomach using the push technique or retrieved using a standard retrieval net. Biopsies were obtained in 51 @entity0 from the proximal and distal parts of the oesophagus at initial gastroscopy. All biopsy specimens were assessed and reviewed by dedicated gastrointestinal pathologists at the Department of Pathology, University Hospital Geelong. The diagnosis of @entity7 was defined and established by the presence of the following histological features: (1) peak eosinophil counts > 20/hpf; (2) eosinophil microabscess; (3) superficial layering of eosinophils; (4) extracellular eosinophil granules; (5) @entity6 ; (6) dilated intercellular spaces; and (7) subepithelial or lamina propria @entity1 . The histology results of the biopsy specimens were accessed from the pathology database of the hospital and recorded for analysis. RESULTS: Our cohort had a median age of 60. Seventeen/51 (33%) @entity0 had evidence of @entity7 on biopsy findings. The majority of @entity0 with @entity7 were male (71%). Classical endoscopic features of oesophageal rings, furrows or white plaques and exudates were found in 59% of @entity0 with @entity7 . Previous episodes of FBO were present in 12/17 @entity0 and 41% had a history of @entity4 , hay @entity2 or @entity5 . @entity3 and benign strictures were found in 20/34 @entity0 who did not have biopsies. CONCLUSION: @entity7 is present in approximately one third of @entity0 who are admitted with FBO. Biopsies should be performed routinely at index endoscopy in order to pursue this treatable cause of long term morbidity.

title: Prevalence of XXXX in adults presenting with oesophageal food @entity9 .

answer: @entity7


abstract: AIM: To evaluate outcomes of combined pars plana vitrectomy and @entity3 implant ( @entity4 -BGI) placement for @entity3 . METHODS: The medical records of 92 eyes (89 @entity0 ) that underwent @entity4 -BGI were retrospectively reviewed, including 43 eyes with @entity5 ( @entity5 ) and 49 eyes with other types of @entity3 (non- @entity5 ). RESULTS: Outcome measures were visual acuity (VA), intraocular pressure (IOP), @entity3 medical therapy, complications, and success [VA>hand motions (HM), IOP>= 6 mm Hg and  <=21 mm Hg, no subsequent @entity3 surgery]. Cumulative success rates for the non- @entity5 group and @entity5 group were 79% and 40% at 1y, respectively (P=0.038). No difference in the rates of surgical success were found between pars plana and anterior chamber tube placement. Preoperative IOP (mean  SD) was 30.3  11.7 mm Hg in the Non- @entity5 group and 40.0  10.6 mm Hg in the @entity5 group, and IOP was reduced to 15  9.5 mm Hg in the non- @entity5 group and 15  10.5 mm Hg in the @entity5 at 1y. Number of @entity3 medications (mean  SD) decreased from 2.7  1.3 in the non- @entity5 group and 2.8  1.3 in the @entity5 group preoperatively to 0.76  1.18 in the non- @entity5 group and 0.51  1.00 in the @entity5 group at 1y. Improvement in VA of >= 2 Snellen lines was observed in 25 (27%) eyes, although only 33% of non- @entity5 eyes and 2.3% of @entity5 eyes maintained VA better than 20/200 at 1y. Nonclearing @entity2 was the most common @entity1 occurring in 16 (17%) eyes, and postoperative @entity2 developed in 5 (5.4%) eyes. CONCLUSION: @entity4 -BGI is a viable surgical option for eyes with @entity3 , but visual outcomes are frequently poor because of ocular comorbidities, especially in eyes with @entity5 . The location of tube placement does not influence surgical outcome and should be left to the discretion of the surgeon.

title: Combined pars plana vitrectomy and XXXX implant placement for @entity3 .

answer: @entity3


abstract: AIM: To evaluate outcomes of combined pars plana vitrectomy and @entity3 implant ( @entity4 -BGI) placement for @entity3 . METHODS: The medical records of 92 eyes (89 @entity0 ) that underwent @entity4 -BGI were retrospectively reviewed, including 43 eyes with @entity5 ( @entity5 ) and 49 eyes with other types of @entity3 (non- @entity5 ). RESULTS: Outcome measures were visual acuity (VA), intraocular pressure (IOP), @entity3 medical therapy, complications, and success [VA>hand motions (HM), IOP>= 6 mm Hg and  <=21 mm Hg, no subsequent @entity3 surgery]. Cumulative success rates for the non- @entity5 group and @entity5 group were 79% and 40% at 1y, respectively (P=0.038). No difference in the rates of surgical success were found between pars plana and anterior chamber tube placement. Preoperative IOP (mean  SD) was 30.3  11.7 mm Hg in the Non- @entity5 group and 40.0  10.6 mm Hg in the @entity5 group, and IOP was reduced to 15  9.5 mm Hg in the non- @entity5 group and 15  10.5 mm Hg in the @entity5 at 1y. Number of @entity3 medications (mean  SD) decreased from 2.7  1.3 in the non- @entity5 group and 2.8  1.3 in the @entity5 group preoperatively to 0.76  1.18 in the non- @entity5 group and 0.51  1.00 in the @entity5 group at 1y. Improvement in VA of >= 2 Snellen lines was observed in 25 (27%) eyes, although only 33% of non- @entity5 eyes and 2.3% of @entity5 eyes maintained VA better than 20/200 at 1y. Nonclearing @entity2 was the most common @entity1 occurring in 16 (17%) eyes, and postoperative @entity2 developed in 5 (5.4%) eyes. CONCLUSION: @entity4 -BGI is a viable surgical option for eyes with @entity3 , but visual outcomes are frequently poor because of ocular comorbidities, especially in eyes with @entity5 . The location of tube placement does not influence surgical outcome and should be left to the discretion of the surgeon.

title: Combined pars plana vitrectomy and @entity3 implant placement for XXXX .

answer: @entity3


abstract: BACKGROUND _ OBJECTIVES: Epidemiological typing of @entity1 is necessary to study genetic relatedness among @entity3 . The Box A PCR assay, a good epidemiological tool for high resolution typing of pneumococcal isolates, was used for comparison of @entity3 of @entity2 from Korea, an area of high @entity0 resistance and India with low resistance to @entity0 . METHODS: The pneumococcal @entity3 from Indian and Korean sources included in the study belonged to serotypes 19F, 23F, 6A _ 6B. The @entity0 susceptibility of the @entity3 was confirmed by determination of minimum inhibitory concentration values. The @entity3 were then fingerprinted using the Box A PCR protocol and the results were further analysed by Molecular Analyst Software. RESULTS: The Box fingerprinting technique produced sharp, clear and reproducible banding patterns for @entity3 of @entity2 included in the study. There was no similarity between Indian and Korean @entity3 at the genetic level. Among the Korean @entity3 with similar serotypes, the level of similarity varied. Except for one pair (serotype 23F), that showed a level of homology of about 90 per cent, almost all the others showed less than 80 per cent homology. It was also seen that there was a high percentage of homology (> 90% in nasopharyngeal isolates from India belonging to serotype 19F) between isolates from similar source. Comparison of the Indian and Korean isolates of similar serotype showed low homology, except for one cluster of two @entity3 with serotype 6B which showed 84 per cent homology (blood isolates from India and Korea). INTERPRETATION _ CONCLUSION: Box A PCR is a highly discriminatory and useful method for typing @entity2 . The results of the study have shown low levels of homology between @entity3 from within India and also between two geographically distinct areas.

title: Epidemiological typing of XXXX from various sources in India _ Korea using Box A PCR fingerprinting.

answer: @entity1


abstract: Due to the potential ethical and psychological implications of screening, and especially in regard of screening on @entity0 without available and acceptable therapeutic measures, there is a common view that such procedures are not advisable. As part of an independent research- and bioethical case study, our aim was therefore to explore and describe bioethical issues among a representative sample of @entity0 families (n = 17,055 @entity0 ) in the ABIS (All Babies In South-east Sweden) research screening for @entity2 ( @entity2 ). The primary aim is the identification of risk factors important for the development of @entity1 and other multifactorial immune-mediated diseases. Four hundred, randomly chosen, @entity0 mothers were asked to complete a questionnaire exploring issues of information, informed consent, bio-material, confidentiality and autonomy, and of prevention/intervention. 293 completed the questionnaire, resulting in a response rate of 73.3%. The majority of questions had the form of 6-point Likert-type response scales (1-6). We found that the majority of respondents felt calm in in regard of samples and written material, and also concerning the possibility of their @entity0 in the future being identified as having high risk of developing @entity2 . An important finding concerning access and control of mainly biological data was indicated, with the respondents expressing concern for potential future use. We believe our findings indicate that this kind of empirical studies can substantially contribute to our understanding of bioethical issues of medical research involving genetics. Issues, such as safeguards ensuring the ethical criteria of autonomy and respect, were emphasised by our respondents. We believe the issues brought up may promote further discussion, and do suggest issues for consideration by, among others, researchers, bioethicists and Institutional Review Boards.

title: Bioethical theory and practice in genetic screening for type 1 XXXX .

answer: @entity1


abstract: The study was conducted to assess the possible impact of @entity3 in @entity0 with @entity5 ( @entity5 ) on tibial nerve somatosensory evoked potentials (t-SSEPs) and the influence of spine correction upon postoperative SSEP recordings. In 61 consecutive @entity0 undergoing 64 spinal instrumentations, 129 pre- and postoperative SSEPs were analyzed. The degree of @entity3 was assessed by the pre-operative Cobb angle of the major scoliotic curve. In a control group, reference values of t-SSEP latencies were established with respect to body height. In a cohort study, @entity5 @entity0 were compared with healthy controls with respect to t-SSEP latency, amplitude, configuration and interside difference. The results of the analysis showed that preoperative-body-height-corrected t-SSEP latencies were prolonged in 61% of @entity0 , with a pathological interside difference in 23.4% of them. The impairment of t-SSEPs was not related to the extent of @entity3 as assessed by the Cobb angle. Even without occurrence of postoperative @entity2 , postoperative t-SSEPs showed significantly increased latencies without changes in t-SSEP configuration. The prolongation of t-SSEP latencies was related to the surgical procedure (combined ventro-dorsal approach), but not to the extent of spine correction, level of instrumentation, or number of fused segments. The analysis of preoperative t-SSEPs was of no predictive @entity1 . t-SSEPs are significantly affected in @entity5 @entity0 , although these @entity0 show no obvious clinical @entity2 . The extent of t-SSEP impairment is not related to the severity of @entity4 . Even in clinically uneventful surgery, the postoperative t-SSEPs can be deteriorated depending on the surgical approach. This indicates a subclinical impact of spine surgery upon spinal cord function.

title: SSEP analysis in surgery of @entity5 : the influence of XXXX and surgical approach.

answer: @entity3


abstract: The study was conducted to assess the possible impact of @entity3 in @entity0 with @entity5 ( @entity5 ) on tibial nerve somatosensory evoked potentials (t-SSEPs) and the influence of spine correction upon postoperative SSEP recordings. In 61 consecutive @entity0 undergoing 64 spinal instrumentations, 129 pre- and postoperative SSEPs were analyzed. The degree of @entity3 was assessed by the pre-operative Cobb angle of the major scoliotic curve. In a control group, reference values of t-SSEP latencies were established with respect to body height. In a cohort study, @entity5 @entity0 were compared with healthy controls with respect to t-SSEP latency, amplitude, configuration and interside difference. The results of the analysis showed that preoperative-body-height-corrected t-SSEP latencies were prolonged in 61% of @entity0 , with a pathological interside difference in 23.4% of them. The impairment of t-SSEPs was not related to the extent of @entity3 as assessed by the Cobb angle. Even without occurrence of postoperative @entity2 , postoperative t-SSEPs showed significantly increased latencies without changes in t-SSEP configuration. The prolongation of t-SSEP latencies was related to the surgical procedure (combined ventro-dorsal approach), but not to the extent of spine correction, level of instrumentation, or number of fused segments. The analysis of preoperative t-SSEPs was of no predictive @entity1 . t-SSEPs are significantly affected in @entity5 @entity0 , although these @entity0 show no obvious clinical @entity2 . The extent of t-SSEP impairment is not related to the severity of @entity4 . Even in clinically uneventful surgery, the postoperative t-SSEPs can be deteriorated depending on the surgical approach. This indicates a subclinical impact of spine surgery upon spinal cord function.

title: SSEP analysis in surgery of XXXX : the influence of @entity3 and surgical approach.

answer: @entity5


abstract: @entity2 in @entity3 ( @entity3 ) is considered uncommon, and the possible mechanisms involved in its insorgence are only speculative. We analyzed a group of 95 @entity0 with severe @entity3 (mean systolic gradient greater than or equal to 50 mmHg and/or aortic valve area less than or equal to 0.7 cm2) studied by standard hemodynamic techniques. In the study group the incidence of @entity2 was 50.5%. We divided the overall population in: Group I (47 @entity0 ), with @entity4 (PAP) less than or equal to 30 mmHg; Group II (33 @entity0 ), with moderate @entity1 (PAP 31-50 mmHg); Group III (15 @entity0 ), with severe @entity1 (PAP greater than 50 mmHg). Subjects with @entity2 were slightly older, and had more severe obstruction to left ventricular (LV) outflow. Impairment of LV diastolic function in the presence of @entity2 was expressed by a highly significant increase of LV end-diastolic pressure (p less than .001); reduced ejection performance was represented by a significant decrease of ejection fraction (p less than .01). Pulmonary vascular resistances also appeared to be increased. The correlation between variables showed PAP to be strongly correlated in a positive way to the LV end-diastolic pressure, and in an inverse way to the LV systolic performance (p less than .001 for both). Less striking was the correlation of pulmonary vascular resistances to LV diastolic and systolic function: a reactive and reversible vasoconstriction seemed likely. Surgery was not performed in 8 of the 95 @entity0 : 5 of them died shortly after diagnosis.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity2 in severe XXXX . Incidence, mechanisms, clinical and surgical implications.

answer: @entity3


abstract: @entity2 in @entity3 ( @entity3 ) is considered uncommon, and the possible mechanisms involved in its insorgence are only speculative. We analyzed a group of 95 @entity0 with severe @entity3 (mean systolic gradient greater than or equal to 50 mmHg and/or aortic valve area less than or equal to 0.7 cm2) studied by standard hemodynamic techniques. In the study group the incidence of @entity2 was 50.5%. We divided the overall population in: Group I (47 @entity0 ), with @entity4 (PAP) less than or equal to 30 mmHg; Group II (33 @entity0 ), with moderate @entity1 (PAP 31-50 mmHg); Group III (15 @entity0 ), with severe @entity1 (PAP greater than 50 mmHg). Subjects with @entity2 were slightly older, and had more severe obstruction to left ventricular (LV) outflow. Impairment of LV diastolic function in the presence of @entity2 was expressed by a highly significant increase of LV end-diastolic pressure (p less than .001); reduced ejection performance was represented by a significant decrease of ejection fraction (p less than .01). Pulmonary vascular resistances also appeared to be increased. The correlation between variables showed PAP to be strongly correlated in a positive way to the LV end-diastolic pressure, and in an inverse way to the LV systolic performance (p less than .001 for both). Less striking was the correlation of pulmonary vascular resistances to LV diastolic and systolic function: a reactive and reversible vasoconstriction seemed likely. Surgery was not performed in 8 of the 95 @entity0 : 5 of them died shortly after diagnosis.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX in severe @entity3 . Incidence, mechanisms, clinical and surgical implications.

answer: @entity2


abstract: The authors report a case of spontaneous bilateral diaphyseal femoral fractures believed to be caused by oversuppression of bone remodeling as a result of long-term, high-dose treatment with @entity4 . The @entity0 reported @entity1 in both thighs before the fractures. Typical pathologic changes appeared on both femoral radiograph and bone scan before the fractures. Several hours after admission to the emergency department of the authors' institution, the @entity0 underwent closed reduction and internal fixation with intramedullary nails for the bilateral femoral diaphyseal fractures. Treatment with @entity3 was immediately discontinued. In recent years, @entity2 in @entity0 undergoing long-term @entity4 treatment have been reported. It is believed that the prolonged treatment causes long-term suppression of bone remodeling and accumulation of microdamage. It is important to observe @entity0 who are undergoing @entity4 treatment carefully. In this case study, the authors report the @entity0 's unique medical history. [Orthopedics. 2015; 38(11):e1051-e1054.].

title: Spontaneous Bilateral Femoral Fractures After High-Dose XXXX .

answer: @entity3


abstract: Pediatric @entity2 are rare injuries that are associated with a high risk of @entity3 of the femoral head. This study compared pediatric @entity0 with fully displaced @entity2 treated with either open reduction and internal fixation (ORIF) or @entity4 ( @entity4 ). After institutional review board approval was obtained, the authors identified 53 @entity0 who were treated for @entity2 between 2003 and 2012. Inclusion criteria were as follows: (1) diagnosis of a fully displaced @entity2 with no anatomic cortical contact; (2) age of at least 4 years; and (3) clinical/radiographic follow-up of at least 1 year. Medical records and radiographs were retrospectively reviewed. Excluded from the study were 16 @entity0 who had @entity1 that were not fully displaced, 4 who were outside of the eligible age range, 1 who had insufficient radiographs, and 10 who had insufficient follow-up. Of the 22 @entity0 included, 6 were treated with ORIF and 16 were treated with @entity4 . Treatment groups were compared with Fisher's exact test for categorical outcome data and the Wilcoxon rank-sum test for continuous variables. There was a significantly (P=.051) greater occurrence of @entity3 after @entity4 (50%) than after ORIF (0%). Further, @entity0 who underwent ORIF had a higher (P=.009) quality of reduction, a higher (P=.046) rate of anatomic union, and fewer (P=.009) complications than those who underwent @entity4 . Major complications occurred in significantly fewer (P=.015) hips after ORIF than after @entity4 . No significant difference (P=.477) was seen between groups, according to the Ratliff assessment of final results. Fully displaced pediatric @entity2 treated with ORIF had a significantly higher quality of reduction, with fewer complications, including @entity3 , than those treated with @entity4 . [Orthopedics. 2015; 38(11):e983-e990.].

title: Open Reduction of Pediatric XXXX Reduces @entity3 Risk.

answer: @entity2


abstract: Pediatric @entity2 are rare injuries that are associated with a high risk of @entity3 of the femoral head. This study compared pediatric @entity0 with fully displaced @entity2 treated with either open reduction and internal fixation (ORIF) or @entity4 ( @entity4 ). After institutional review board approval was obtained, the authors identified 53 @entity0 who were treated for @entity2 between 2003 and 2012. Inclusion criteria were as follows: (1) diagnosis of a fully displaced @entity2 with no anatomic cortical contact; (2) age of at least 4 years; and (3) clinical/radiographic follow-up of at least 1 year. Medical records and radiographs were retrospectively reviewed. Excluded from the study were 16 @entity0 who had @entity1 that were not fully displaced, 4 who were outside of the eligible age range, 1 who had insufficient radiographs, and 10 who had insufficient follow-up. Of the 22 @entity0 included, 6 were treated with ORIF and 16 were treated with @entity4 . Treatment groups were compared with Fisher's exact test for categorical outcome data and the Wilcoxon rank-sum test for continuous variables. There was a significantly (P=.051) greater occurrence of @entity3 after @entity4 (50%) than after ORIF (0%). Further, @entity0 who underwent ORIF had a higher (P=.009) quality of reduction, a higher (P=.046) rate of anatomic union, and fewer (P=.009) complications than those who underwent @entity4 . Major complications occurred in significantly fewer (P=.015) hips after ORIF than after @entity4 . No significant difference (P=.477) was seen between groups, according to the Ratliff assessment of final results. Fully displaced pediatric @entity2 treated with ORIF had a significantly higher quality of reduction, with fewer complications, including @entity3 , than those treated with @entity4 . [Orthopedics. 2015; 38(11):e983-e990.].

title: Open Reduction of Pediatric @entity2 Reduces XXXX Risk.

answer: @entity3


abstract: Genome-wide association studies (GWASs) help to understand the effects of single nucleotide polymorphisms (SNPs) on @entity0 ( @entity0 ) progression and survival. We performed multiple analyses on data from a previously conducted GWAS for the influence of individual SNPs, @entity2 ( @entity2 ) and inbreeding on @entity0 survival. (I.) The association of individual SNPs indicated no differences in the proportions of homozygous individuals among short-time survivors (STSs) and long-time survivors (LTSs). (II.) The analysis revealed differences among the populations for the number of @entity2 per @entity1 and the total and average length of @entity2 per @entity1 and among LTSs and STSs for the number of @entity2 per @entity1 . (III.) Common @entity2 at particular genomic positions were nominally more frequent among LTSs than in STSs. Common @entity2 showed significant evidence for natural selection (iHS, Tajima's D, Fay-Wu's H). Most regions could be linked to genes related to @entity0 progression or treatment. (IV.) Results were supported by a higher level of inbreeding among LTSs. Our results showed that an increased level of homozygosity may result in a preference of individuals during @entity0 treatment. Although common @entity2 were short, variants within @entity2 might favor survival of @entity0 and may function in a recessive manner.

title: Inbreeding and homozygosity in XXXX survival.

answer: @entity0


abstract: A multicenter randomized controlled study was conducted to assess the long-term efficacy and safety of @entity4 therapy for @entity6 using either a continuous or an intermittent regimen. Initially, both regimens consisted of 3-5 mg/kg/day administration of CyA. Once remission was obtained, CyA dose was maintained between 0.5 and 3 mg/kg/day under the continuous regimen, while under the intermittent regimen, CyA dose was tapered off and, when necessary, topical corticosteroids were used until relapse occurred. Thirty-one @entity0 were followed for at least 48 months (mean follow-up period: 55.9+/-4.6 months): 15 received continuous therapy, and 16 received intermittent therapy. With both regimens, the PASI (Psoriasis Area and Severity Index) score was maintained at 5-12 points throughout the follow-up period. The score was decreased by more than 70% from baseline with both regimens: the responses between them were not significantly different. However, overall control of @entity6 , as assessed from the averaged PASI score, was better in the @entity0 receiving continuous therapy. Although the overall frequency of adverse reactions was similar for the two regimens, @entity1 occurred in two @entity0 on continuous therapy ( @entity5 and @entity3 in one @entity0 each). We could not, however, @entity1 in the two @entity0 to continuous therapy itself. There was a significantly higher incidence of @entity2 in elderly @entity0 receiving either regimen when compared with younger @entity0 . In conclusion, CyA administered to @entity6 @entity0 under both regimens exhibited long-term efficacy and tolerability. Despite a lower overall efficacy, it seems proper to conclude that intermittent therapy is more useful than continuous therapy due to the occurrence of @entity1 with continuous therapy. Further investigation is required to determine whether intermittent therapy is really safer than continuous therapy, and, if so, how it should be designed to minimize long-term adverse reactions and achieve overall control comparable to that of continuous CyA therapy.

title: Long-term continuous versus intermittent XXXX : therapy for @entity6 .

answer: @entity4


abstract: A multicenter randomized controlled study was conducted to assess the long-term efficacy and safety of @entity4 therapy for @entity6 using either a continuous or an intermittent regimen. Initially, both regimens consisted of 3-5 mg/kg/day administration of CyA. Once remission was obtained, CyA dose was maintained between 0.5 and 3 mg/kg/day under the continuous regimen, while under the intermittent regimen, CyA dose was tapered off and, when necessary, topical corticosteroids were used until relapse occurred. Thirty-one @entity0 were followed for at least 48 months (mean follow-up period: 55.9+/-4.6 months): 15 received continuous therapy, and 16 received intermittent therapy. With both regimens, the PASI (Psoriasis Area and Severity Index) score was maintained at 5-12 points throughout the follow-up period. The score was decreased by more than 70% from baseline with both regimens: the responses between them were not significantly different. However, overall control of @entity6 , as assessed from the averaged PASI score, was better in the @entity0 receiving continuous therapy. Although the overall frequency of adverse reactions was similar for the two regimens, @entity1 occurred in two @entity0 on continuous therapy ( @entity5 and @entity3 in one @entity0 each). We could not, however, @entity1 in the two @entity0 to continuous therapy itself. There was a significantly higher incidence of @entity2 in elderly @entity0 receiving either regimen when compared with younger @entity0 . In conclusion, CyA administered to @entity6 @entity0 under both regimens exhibited long-term efficacy and tolerability. Despite a lower overall efficacy, it seems proper to conclude that intermittent therapy is more useful than continuous therapy due to the occurrence of @entity1 with continuous therapy. Further investigation is required to determine whether intermittent therapy is really safer than continuous therapy, and, if so, how it should be designed to minimize long-term adverse reactions and achieve overall control comparable to that of continuous CyA therapy.

title: Long-term continuous versus intermittent @entity4 : therapy for XXXX .

answer: @entity6


abstract: BACKGROUND: Identification of risks for development of @entity5 ( @entity5 ), which might be identified early after injury, would allow for prognostic estimates and targeting of high-risk cohorts for clinical trials of preventive strategies. This study was performed to develop an equation that can be applied to estimate the probability of @entity1 based on parameters collected in the early postinjury interval. METHODS: Over a 28-month period, @entity0 admissions were reviewed for mechanism and severity of injury, patterns of injury, shock, and need for emergent intubation. Early deaths (<48 hours) were excluded. @entity5 diagnosis required > or = 10(5) colony-forming units/mL organisms in the bronchoalveolar lavage effluent. Multiple logistic regression analysis was used to develop the prediction equation and estimate odds ratios. The equation was then tested on consecutive @entity0 admitted over a 2-month period. RESULTS: We reviewed 9,721 admissions (77% blunt, 23% penetrating). @entity5 incidence was 5.6%. Overall mortality was 2% (21% for @entity0 with @entity5 vs. 1% for no @entity5 ; p < 0.0001). Multiple logistic regression analysis for all @entity0 produced the following equation: f(x) = -3.08 - 1.56 (MOI) - 0.12 (GCS) + 1.37 (SCI) + 0.30 (chest AIS) + 1.87 ( @entity6 ) + 0.67 (tx) + 0.05 (ISS) + 0.66 (int), where MOI is mechanism of injury (penetrating = 1, blunt = 0), GCS is Glasgow @entity3 Scale score, SCI is @entity4 (yes = 1, no = 0), @entity6 is emergent laparotomy (yes = 1, no = 0), ISS is Injury Severity Score, tx is units of blood transfused in the resuscitation room, and int is intubation in either the field or the resuscitation room (yes = 1, no = 0). The probability of @entity5 was calculated as follows: P( @entity5 ) = e(f)(x)/1 + e(f)(x). This formula was concordant in 95% and discordant in 5%. CONCLUSION: It is possible to accurately predict risk for @entity5 in @entity2 @entity0 based on data available early after injury. This calculation could be useful for counseling families relative to prognosis and research protocols, and addressing hospitalization issues with third-party payors.

title: A formula for prediction of posttraumatic XXXX based on early anatomic and physiologic parameters.

answer: @entity1


abstract: BACKGROUND: Appropriate surgical management of type A dissection is a critical factor for achieving satisfactory outcome, but the choice of optimal procedure is controversial. We retrospectively reviewed our experience with aortic arch replacement for type A dissection involving the arch. METHODS AND RESULTS: Excluding 14 cases of subtotal or total aortic replacement, 411 of 544 @entity0 with type A dissection (stented @entity3 trunk=291, conventional surgical repair=120) underwent aortic arch replacement between January 2003 and September 2008. In-hospital mortality was 3.09% (9 of 291) for stented (acute=4.73%, 7 of 148; chronic=1.40%, 2 of 143) and 5.00% (6 of 120) for conventional repairs (acute=6.06%, 4 of 66; chronic=3.70%, 2 of 54). @entity2 was 2.41% (7 of 291) in the stented and 0.83% (1 of 120) in the conventional group. The overall prevalence of @entity1 was 1.95% (8 of 411) (stented=2.41%, 7 of 291; conventional=0.83, 1 of 120). Secondary intervention was 2.34% (5 of 214) for acute dissection (stented=1 and conventional=4; P=0.031) and 3.05% (6 of 197) for chronic dissection (stented=4 and conventional=2; P=0.661) during follow-up. Obliteration of the false lumen around the stented @entity3 trunk occurred in 94.2% (130 of 138) of @entity0 with acute dissection and in 92.0% (126 of 137) of @entity0 with chronic dissection. CONCLUSIONS: Total arch replacement combined with stented @entity3 trunk implantation demonstrated the superiority of the combination of the surgical and interventional approaches while avoiding the weaknesses associated with the individual methods. The encouraging surgical results could enable this procedure to become the new "standard" therapy for type A dissection involving repair of the aortic arch.

title: Total arch replacement combined with stented XXXX trunk implantation: a new "standard" therapy for type a dissection involving repair of the aortic arch?

answer: @entity3


abstract: PURPOSE: Although episcleral buckles are frequently placed as an additional procedure to vitreoretinal surgery, little is known about their independent effect after @entity1 . The authors created a posterior penetrating @entity3 model to evaluate the isolated role of primary episcleral buckle placement. METHODS: Twenty eyes underwent surgery. The @entity2 consisted of two 5-mm circumferential incisions placed five clock hours apart and 8 mm behind the limbus. A segmental episcleral buckle was placed over a randomly chosen injury site after wound closure. The degrees of fibrous proliferation, traction, and the presence of @entity0 were evaluated on follow-up examinations. After enucleation and initial fixation, tissue sectioning was performed, and the greatest dimension of the fibrous proliferation at both wound sites was measured with a caliper. RESULTS: Two eyes were excluded from the study. Three eyes developed a @entity0 ; the remaining 15 eyes showed varying degrees of proliferation and traction on the retina. The greatest dimension of the fibrous proliferation at the buckle site (1.22 +/- 1 mm) was significantly different from that at the nonbuckle site (2 +/- 1.45 mm, P = 0.01). CONCLUSIONS: Primary episcleral buckle placement at the time of surgical repair reduces vitreous traction from the buckle site and decreases the degree of fibrovascular proliferation.

title: The role of scleral buckle in experimental posterior penetrating XXXX .

answer: @entity3


abstract: The data of 825 consecutive @entity0 with @entity2 or TIA were retrospectively reviewed for ultrasound findings of stenoses or occlusions of the middle cerebral artery (MCA). Using survival statistics,we studied the influence of various factors on the prognosis of MCA findings. We identified 90 subjects with MCA @entity5 or @entity3 . Microembolic signals were demonstrated in 33% and spontaneous flow variations in 7%. Symptomatic MCA findings normalized more quickly than asymptomatic findings. Microembolic signals occurred only in symptomatic stenoses. Spontaneous flow variations strongly predicted the disappearance of a @entity5 . Atherogenic risk factors were associated with stable ultrasound findings. These data suggest that different types of MCA findings exist: (1) dynamic, emboligenic stenoses or occlusions with early normalization and a high risk for @entity1 events and (2) static, nonemboligenic stenoses with rare normalization and a low risk of @entity1 events. A high percentage of the former may be of embolic origin, and the latter may be @entity4 .

title: [Determinants for the prognosis of median cerebral artery processes--a retrospective analysis of 90 XXXX ].

answer: @entity0


abstract: From 1965 to 1985, 64 @entity2 ( @entity2 ) @entity0 were treated with streptokinase (SK). In 26 cases 'high-dose SK' (IV 100,000 units/h for 4 days) was used and in 38 @entity0 a 'low-dose SK' regime (IV 250,000 units every 12 h for 4 days) was employed. The clinical signs of @entity2 subsided in 78 per cent of treated @entity0 within 30 days of completing SK treatment. A repeat phlebography was performed immediately after SK therapy in 29 @entity0 (45 per cent) and a total recanalization or partial thrombolysis was achieved in 80 per cent of the studied cases. In 15 @entity0 minor and major @entity1 occurred. There were five fatalities, all in the high-dose SK group (three intracranial @entity1 and two major @entity1 ). Three @entity0 developed @entity3 and none of them died. The post-treatment clinical and phlebographic evaluation did not reveal any significant difference between the two methods of SK administration, but more @entity1 (P less than 0.02, chi=5.50825) occurred in the high-dose SK @entity0 . This report emphasizes the risk of @entity1 complications during thrombolytic therapy. If SK is to be used, therefore, careful selection of @entity0 and meticulous monitoring are mandatory.

title: Hazards of thrombolytic therapy in XXXX .

answer: @entity2


abstract: Corticosteroid (CS)-related @entity2 risk in @entity3 ( @entity3 ) is unknown. The aim of this study was to assess the adjusted CS risk function of severe @entity2 in persistent or chronic primary @entity3 adults. We designed a nested case-control study in the FAITH cohort. This cohort is built through the French national health insurance database named SNIIRAM and includes all treated incident persistent or chronic primary @entity3 adults in France (ENCePP n  4574). @entity0 who entered the FAITH cohort between 2009 and 2012 were eligible (n = 1805). Cases were @entity0 with @entity2 as primary diagnosis code during hospitalization. Index date was the date of first hospitalization for @entity2 . A 2:1 matching was performed on age and entry date in the cohort. Various CS exposure time-windows were defined: current user, exposure during the 1/3/6 months preceding index date and from the entry date. CS doses were converted in @entity1 equivalent (PEQ). The cumulative CS doses were averaged in each time-window to obtain daily PEQ dosages. Each CS exposure definition was assessed using multivariate conditional regression models. During the study period, 161 cases (9 opportunistic) occurred. The model with the best goodness of fit was CS exposure during the month before the index date (OR: 2.48, 95% CI: 1.61-3.83). The dose-effect relation showed that the risk existed from averaged daily doses >= 5 mg PEQ (vs. <5 mg: 2.09, 95% CI: 1.17-3.71). The risk of @entity2 was mainly supported by current or recent exposure to CS, even with low doses.

title: Corticosteroid Risk Function of Severe Infection in Primary XXXX Adults. A Nationwide Nested Case-Control Study.

answer: @entity3


abstract: Natural killer (NK) cells play an important role in immune surveillance against a variety of infectious microorganisms and @entity1 . Limited availability of NK cells and ability to expand in vitro has restricted development of NK cell immunotherapy. Here we describe a method to efficiently expand vast quantities of functional NK cells ex vivo using K562 cells expressing membrane-bound @entity9 , as an artificial antigen-presenting cell (aAPC). NK cell adoptive therapies to date have utilized a cell product obtained by steady-state leukapheresis of the donor followed by depletion of T cells or positive selection of NK cells. The product is usually activated in @entity2 overnight and then administered the following day. Because of the low frequency of NK cells in peripheral blood, relatively small numbers of NK cells have been delivered in clinical trials. The inability to propagate NK cells in vitro has been the limiting factor for generating sufficient cell numbers for optimal clinical outcome. Some expansion of NK cells (5-10 fold over 1-2 weeks) has be achieved through high-dose @entity2 alone. Activation of autologous T cells can mediate NK cell expansion, presumably also through release of local cytokine. Support with mesenchymal stroma or artificial antigen presenting cells (aAPCs) can support the expansion of NK cells from both peripheral blood and cord blood. Combined @entity6 and @entity4 activation by antibody-coated beads is currently marketed for NK cell expansion (Miltenyi Biotec, Auburn CA), resulting in approximately 100-fold expansion in 21 days. Clinical trials using aAPC-expanded or -activated NK cells are underway, one using leukemic cell line @entity0 to prime and activate NK cells without significant expansion. A second trial utilizes EBV-LCL for NK cell expansion, achieving a mean 490-fold expansion in 21 days. The third utilizes a K562-based aAPC transduced with @entity10 ( @entity10 ) and membrane-bound IL-15 (mIL-15), which achieved a mean NK expansion 277-fold in 21 days. Although, the NK cells expanded using K562-41BBL-mIL15 aAPC are highly cytotoxic in vitro and in vivo compared to unexpanded NK cells, and participate in @entity8 , their proliferation is limited by senescence attributed to telomere @entity5 . More recently a 350-fold expansion of NK cells was reported using K562 expressing @entity3 , @entity10 and @entity7 . Our method of NK cell expansion described herein produces rapid proliferation of NK cells without senescence achieving a median 21,000-fold expansion in 21 days.

title: Expansion, purification, and functional assessment of XXXX peripheral blood NK cells.

answer: @entity0


abstract: Adult male @entity0 were administered 75 mg/kg of the neurotoxin @entity6 to produce lesions of the inferior olive-climbing fiber projection to the cerebellum. At selected times ranging from 6 h to 43 days postlesion, @entity0 were evaluated for @entity1 , and @entity2 decarboxylase (GAD) activity was determined in the deep cerebellar nuclei and cerebellar vermis. In the deep nuclei non-monotonic changes in GAD activity were found following climbing fiber destruction. Initially, there was a steady increase in GAD activity which peaked at 38% above control values 14 days postlesion. GAD activity then slowly declined, although it remained significantly above control levels at 43 days postlesion, the latest time point examined. In the vermis, GAD activity was significantly increased at 4 days postlesion (+8%) and remained at approximately this level throughout the experiment. The initial behavioral effects of climbing fiber loss included @entity5 and @entity4 with severely reduced mobility. With time, the @entity4 and @entity5 decreased and movements such as mud-walking and pivoting developed. As these behaviors diminished, other novel conditions such as movement-associated @entity3 and hopping appeared. These results are discussed in the context of the previously reported effects of climbing fiber lesions on the firing rates of Purkinje cells and deep nuclei cells.

title: Temporal sequence of motor disturbances and increased cerebellar @entity2 decarboxylase activity following XXXX lesions in adult @entity0 .

answer: @entity6


abstract: Adult male @entity0 were administered 75 mg/kg of the neurotoxin @entity6 to produce lesions of the inferior olive-climbing fiber projection to the cerebellum. At selected times ranging from 6 h to 43 days postlesion, @entity0 were evaluated for @entity1 , and @entity2 decarboxylase (GAD) activity was determined in the deep cerebellar nuclei and cerebellar vermis. In the deep nuclei non-monotonic changes in GAD activity were found following climbing fiber destruction. Initially, there was a steady increase in GAD activity which peaked at 38% above control values 14 days postlesion. GAD activity then slowly declined, although it remained significantly above control levels at 43 days postlesion, the latest time point examined. In the vermis, GAD activity was significantly increased at 4 days postlesion (+8%) and remained at approximately this level throughout the experiment. The initial behavioral effects of climbing fiber loss included @entity5 and @entity4 with severely reduced mobility. With time, the @entity4 and @entity5 decreased and movements such as mud-walking and pivoting developed. As these behaviors diminished, other novel conditions such as movement-associated @entity3 and hopping appeared. These results are discussed in the context of the previously reported effects of climbing fiber lesions on the firing rates of Purkinje cells and deep nuclei cells.

title: Temporal sequence of motor disturbances and increased cerebellar XXXX decarboxylase activity following @entity6 lesions in adult @entity0 .

answer: @entity2


abstract: Adult male @entity0 were administered 75 mg/kg of the neurotoxin @entity6 to produce lesions of the inferior olive-climbing fiber projection to the cerebellum. At selected times ranging from 6 h to 43 days postlesion, @entity0 were evaluated for @entity1 , and @entity2 decarboxylase (GAD) activity was determined in the deep cerebellar nuclei and cerebellar vermis. In the deep nuclei non-monotonic changes in GAD activity were found following climbing fiber destruction. Initially, there was a steady increase in GAD activity which peaked at 38% above control values 14 days postlesion. GAD activity then slowly declined, although it remained significantly above control levels at 43 days postlesion, the latest time point examined. In the vermis, GAD activity was significantly increased at 4 days postlesion (+8%) and remained at approximately this level throughout the experiment. The initial behavioral effects of climbing fiber loss included @entity5 and @entity4 with severely reduced mobility. With time, the @entity4 and @entity5 decreased and movements such as mud-walking and pivoting developed. As these behaviors diminished, other novel conditions such as movement-associated @entity3 and hopping appeared. These results are discussed in the context of the previously reported effects of climbing fiber lesions on the firing rates of Purkinje cells and deep nuclei cells.

title: Temporal sequence of motor disturbances and increased cerebellar @entity2 decarboxylase activity following @entity6 lesions in adult XXXX .

answer: @entity0


abstract: BACKGROUND: Short-term results are presented from our first year of experience with transcatheter @entity4 [corrected] (TAVI) at the University Hospital of North Norway. MATERIALS AND METHODS: TAVI was used to treat 25 @entity0 with @entity2 [corrected] from September 2008 to August 2009. 25 @entity0 operated with conventional aortic valve replacement (AVR) served as controls. RESULTS: The TAVI group had a significantly higher EuroSCORE (p < 0.001) than the AVR group. No @entity0 in the TAVI group were treated in the intensive care unit while those in the AVR group received 38 days of intensive care in total. The TAVI group had shorter operating times (p < 0.001), larger mean valve sizes (p < 0.001) and significantly fewer postoperative transfusions (p < 0.001) than the ACR group. Peri-operative @entity1 and @entity3 did not occur in the TAVI group while there was one incidence of @entity1 and one @entity3 in the AVR group. The postoperative transvalvular mean gradient decreased in both groups (p < 0.001) and was significantly lower in the TAVI group (p = 0.001). The NYHA class improved significantly in the TAVI group (p < 0.001). No @entity0 needed implantation of a permanent pacemaker. 30-day mortality was four @entity0 in the AVR group and one @entity0 in the TAVI group. After discharge one @entity0 died in each group. INTERPRETATION: TAVI is safe and effective for selected @entity0 with @entity2 [corrected] who are assessed as high risk for AVR. Long-term results are needed and will be decisive for use of this approach in the future.

title: Transcatheter @entity4 for XXXX .

answer: @entity2


abstract: BACKGROUND: Short-term results are presented from our first year of experience with transcatheter @entity4 [corrected] (TAVI) at the University Hospital of North Norway. MATERIALS AND METHODS: TAVI was used to treat 25 @entity0 with @entity2 [corrected] from September 2008 to August 2009. 25 @entity0 operated with conventional aortic valve replacement (AVR) served as controls. RESULTS: The TAVI group had a significantly higher EuroSCORE (p < 0.001) than the AVR group. No @entity0 in the TAVI group were treated in the intensive care unit while those in the AVR group received 38 days of intensive care in total. The TAVI group had shorter operating times (p < 0.001), larger mean valve sizes (p < 0.001) and significantly fewer postoperative transfusions (p < 0.001) than the ACR group. Peri-operative @entity1 and @entity3 did not occur in the TAVI group while there was one incidence of @entity1 and one @entity3 in the AVR group. The postoperative transvalvular mean gradient decreased in both groups (p < 0.001) and was significantly lower in the TAVI group (p = 0.001). The NYHA class improved significantly in the TAVI group (p < 0.001). No @entity0 needed implantation of a permanent pacemaker. 30-day mortality was four @entity0 in the AVR group and one @entity0 in the TAVI group. After discharge one @entity0 died in each group. INTERPRETATION: TAVI is safe and effective for selected @entity0 with @entity2 [corrected] who are assessed as high risk for AVR. Long-term results are needed and will be decisive for use of this approach in the future.

title: Transcatheter XXXX for @entity2 .

answer: @entity4


abstract: Previous results following subfascial endoscopic perforator vein surgery were reported to be worse in post-thrombotic syndrome than in limbs with primary @entity1 . This report comprises a larger @entity0 cohort with longer follow-up. The goal of this study was to determine if subfascial endoscopic perforator vein surgery is justified in @entity0 with post-thrombotic @entity4 . The clinical data of 91 consecutive @entity0 who underwent subfascial endoscopic perforator vein surgery with or without superficial reflux ablation over a 7-year period from May 1993 to June 2000 were retrospectively analyzed. Fifty-four females and 37 males (median age, 53 years; range, 20-77) underwent 103 subfascial endoscopic perforator vein surgery procedures. Forty-two limbs were classified as C6 (active @entity2 ), 34 as C5 (healed @entity2 ), and 24 as C4 ( @entity5 ). Thirty procedures were performed in post-thrombotic limbs. Concomitant superficial reflux ablation was performed in 74 limbs (72%); saphenous vein stripping had been previously performed in 29 (28%). Deep @entity3 was present in 89% of limbs; 13% had venous outflow obstruction on plethysmography. Cumulative @entity2 in post-thrombotic limbs was not significantly different from limbs with primary @entity1 ; 30-, 60-, and 90-day healing rates were 44%, 72%, and 72% vs 39%, 70%, and 87%, respectively (p = 0.35). On univariate analysis, the presence of @entity2 greater than 2 cm in diameter was associated with delayed @entity2 (p = 0.02). Cumulative @entity2 in all limbs was 4%, 20%, and 27% at 1, 3, and 5 years, respectively. Ulcer recurrence in post-thrombotic limbs was higher than in limbs with primary @entity1 at 1, 3, and 5 years; 16%, 47%, and 56% vs 0%, 8%, and 15%, respectively (p = 0.001). Recurrent @entity2 were small, superficial, and easier to heal. Clinical improvement was significant even in post-thrombotic limbs; median clinical score decreased from 9.5 to 3 (p = 0.001), and median outcome score was +2 (mean 1.9; range, -1 to 3). Median clinical score in @entity0 with primary @entity1 improved from 6 to 1.5 (p = 0.0001). Subfascial endoscopic perforator vein surgery with superficial reflux ablation promoted @entity2 , improved clinical outcome, and resulted in a low long-term @entity2 rate in limbs with primary @entity1 . Despite good clinical outcome in post-thrombotic limbs, @entity2 was high. These results imply that the role of subfascial endoscopic perforator vein surgery with superficial reflux ablation in @entity0 with post-thrombotic limbs continues to be controversial.

title: Subfascial endoscopic perforator vein surgery in @entity0 with post-thrombotic XXXX --is it justified?

answer: @entity4


abstract: Previous results following subfascial endoscopic perforator vein surgery were reported to be worse in post-thrombotic syndrome than in limbs with primary @entity1 . This report comprises a larger @entity0 cohort with longer follow-up. The goal of this study was to determine if subfascial endoscopic perforator vein surgery is justified in @entity0 with post-thrombotic @entity4 . The clinical data of 91 consecutive @entity0 who underwent subfascial endoscopic perforator vein surgery with or without superficial reflux ablation over a 7-year period from May 1993 to June 2000 were retrospectively analyzed. Fifty-four females and 37 males (median age, 53 years; range, 20-77) underwent 103 subfascial endoscopic perforator vein surgery procedures. Forty-two limbs were classified as C6 (active @entity2 ), 34 as C5 (healed @entity2 ), and 24 as C4 ( @entity5 ). Thirty procedures were performed in post-thrombotic limbs. Concomitant superficial reflux ablation was performed in 74 limbs (72%); saphenous vein stripping had been previously performed in 29 (28%). Deep @entity3 was present in 89% of limbs; 13% had venous outflow obstruction on plethysmography. Cumulative @entity2 in post-thrombotic limbs was not significantly different from limbs with primary @entity1 ; 30-, 60-, and 90-day healing rates were 44%, 72%, and 72% vs 39%, 70%, and 87%, respectively (p = 0.35). On univariate analysis, the presence of @entity2 greater than 2 cm in diameter was associated with delayed @entity2 (p = 0.02). Cumulative @entity2 in all limbs was 4%, 20%, and 27% at 1, 3, and 5 years, respectively. Ulcer recurrence in post-thrombotic limbs was higher than in limbs with primary @entity1 at 1, 3, and 5 years; 16%, 47%, and 56% vs 0%, 8%, and 15%, respectively (p = 0.001). Recurrent @entity2 were small, superficial, and easier to heal. Clinical improvement was significant even in post-thrombotic limbs; median clinical score decreased from 9.5 to 3 (p = 0.001), and median outcome score was +2 (mean 1.9; range, -1 to 3). Median clinical score in @entity0 with primary @entity1 improved from 6 to 1.5 (p = 0.0001). Subfascial endoscopic perforator vein surgery with superficial reflux ablation promoted @entity2 , improved clinical outcome, and resulted in a low long-term @entity2 rate in limbs with primary @entity1 . Despite good clinical outcome in post-thrombotic limbs, @entity2 was high. These results imply that the role of subfascial endoscopic perforator vein surgery with superficial reflux ablation in @entity0 with post-thrombotic limbs continues to be controversial.

title: Subfascial endoscopic perforator vein surgery in XXXX with post-thrombotic @entity4 --is it justified?

answer: @entity0


abstract: UNASSIGNED: Study Design Secondary analysis of a randomized controlled trial. Background The use of external supports has been questioned because they may lead to weakness in the surrounding muscles. To our knowledge, there is no investigation into the effect of knee supports or braces on quadriceps muscle strength and quadriceps inhibition in individuals with @entity4 . Objective To investigate the effects of a flexible knee support on quadriceps maximum @entity3 (MVC) and @entity1 ( @entity1 ) in @entity0 with @entity4 ( @entity4 ). Methods 108 @entity0 were included with at least 3 months of @entity2 and a K-L score 2 or 3 for @entity4 . Each was randomized to wear a flexible knee support ('brace') or no support ('no brace') in a 6 weeks RCT, after which followed an open label trial with all @entity0 wearing the brace for a total of 12 weeks. At the 6 and 12 weeks' time points quadriceps MVC was measured isometrically and quadriceps @entity1 was measured by twitch interpolation. Results After 6 weeks, MVC did not differ between the 'brace' and 'no brace' group (9.09Nm; 95% CI -4.89Nm to 23.07Nm, p = 0.20). @entity1 significantly decreased in the brace group (-8.62%; 95% CI -13.90 to -3.33%, p = 0.002). After 12 weeks of all @entity0 wearing a flexible knee support, MVC increased by 7.98Nm (95% CI 2.52Nm to 13.45Nm, p = 0.004). @entity1 decreased by -8.42% (95% CI -11.48% to -5.36%; p<0.001).). Although statistically significant, these results have doubtful clinical significance. Conclusion A patellofemoral flexible knee support in @entity0 with @entity4 does not have an @entity3 or @entity1 . Using a knee support should not be discouraged because of concerns about deleterious effects on quadriceps strength and inhibition. Level of Evidence Therapy, level 1b. J Orthop Sports Phys Ther, Epub 10 Nov 2015. doi:10.2519/jospt.2016.5093.

title: The Effect of Knee Braces on Quadriceps Strength and Inhibition in Subjects With XXXX .

answer: @entity4


abstract: Dissociated single cells from @entity1 retina or tectum kept in rotation-mediated cell culture aggregate, proliferate and establish a certain degree of histotypical cell-to-cell relationships ("sorting out"), but these systems never form highly laminated aggregates ("nonstratified" R- and T-aggregates). In contrast, a mixture of retinal plus pigment epithelial cells forms highly "stratified" aggregates ("RPE-aggregates", see Vollmer et al. 1984). The present comparative study of "stratified" and "nonstratified" aggregates enables us to investigate the process of cell proliferation uncoupled from that of tissue stratification. Here we try to relate these two basic neurogenetic processes with patterns of expression of cholinesterases ( @entity2 , @entity3 ) during formation of both types of aggregates. During early aggregate formation, in both "stratified" and "nonstratified" aggregates an increased butyrylcholinesterase activity is observed close to mitotically active cells. Quantitatively both phenomena show their maxima after 2-3 days in culture. In contrast, @entity2 -expression in all systems increases with incubation time. In nonproliferative areas, in the center of RPE-aggregates, the formation of plexiform layers is characterized initially by weak @entity3 - and then strong @entity2 -activity. These areas correspond with the inner (IPL) and outer (OPL) plexiform layers of the retina in vivo. Although by @entity0 gradient centrifugation we find that the 6S- and the fiber-associated 11S-molecules of @entity2 are present in all types of aggregates, during the culture period the ratio of 11S/6S-forms increases only in RPE-aggregates, which again indicates the advanced degree of differentiation within these aggregates.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Cholinesterases and cell proliferation in "nonstratified" and "stratified" cell aggregates from XXXX retina and tectum.

answer: @entity1


abstract: BACKGROUND: Environmental @entity0 smoke (ETS) exposure levels in different restaurant types in Finland were assessed before the National @entity0 Act restricting smoking in restaurants was activated. METHODS: Exposure to ETS was determined by measuring @entity2 in the breathing zone of non-smoking restaurant workers and by quantification of the @entity2 metabolites @entity3 and @entity4 in the urine of these workers during one whole work week. Altogether 23 workers from 15 restaurants were included in the study. RESULTS: The geometric mean (GM) breathing-zone @entity2 level was 3.9 microg/m(3) (3.7 microg/m(3) in pubs, 1.4 microg/m(3) in dining restaurants, and 10.2 microg/m(3) in nightclubs). The GM @entity3 and @entity4 level in urine were 3.3 ng/mg(( @entity1 )) and 15.3 ng/mg(( @entity1 )), respectively. The exposure to ETS of restaurant workers in dining restaurants was clearly lower than that of workers in pubs and nightclubs as indicated by all ETS-markers used in the present study. During the work week, the @entity3 and @entity4 levels in urine of the study subjects increased. The correlation between breathing zone @entity2 and urine @entity3 and @entity4 was 0.66 for both compounds. Post-shift @entity3 and @entity4 levels were not significantly higher than the pre-shift levels. CONCLUSIONS: If 9 ng @entity3 /mg(( @entity1 )) is considered as the level above which heavy exposure has occurred, then this level was exceeded by 14 (approximately 60%) subjects at least once during the work week. @entity2 metabolite concentrations in the urine increased during the work week in 80% of the subjects, and the increase was especially noticeable for subjects working in both pubs and nightclubs. The study indicates that measures to restrict ETS exposure in restaurants are needed.

title: Occupational exposure of non-smoking restaurant personnel to environmental XXXX smoke in Finland.

answer: @entity0


abstract: Testicular development was studied in @entity2 (tree-shrew) from birth to sexual maturity. At birth the seminiferous cords contained peripheral supporting cells and centrally located gonocytes. Large foetal Leydig cells were prominent in the interstitium. The mitotic index of the gonocytes was low at birth and rose to peak levels at Day 20, following the regression of the foetal generation of Leydig cells, and during the nadir in circulating @entity0 concentrations. Mitotic activity returned to low levels at Day 30 in association with the reappearance of differentiated Leydig cells and the first signs of increased androgenesis. The negative temporal relationship between mitogenesis and androgenic function suggests that the proliferation of the gonocytes does not require, and may be inhibited by, high titres of @entity1 . Post-mitotic development of the gonocytes occurred during a period of rising @entity0 levels, and the first appearance of spermatogonia coincided with peak @entity0 levels. This indicates that @entity1 may be specifically involved in the initiation of spermatogenesis. Spermatogenesis progressed to completion during a phase of declining @entity0 levels. The precise temporal correlations established during post-natal development suggest that the tree-shrew is a suitable animal model for studies on the endocrine control of the initiation of spermatogenesis in primates.

title: Postnatal differentiation of the gametogenic and endocrine functions of the testis in the tree-shrew ( XXXX ).

answer: @entity2


abstract: INTRODUCTION: @entity6 ( @entity9 ) is an established predictor of perioperative @entity7 following both cardiac and non-cardiac surgery. The purpose of this study was to evaluate the risk of mortality and perioperative @entity7 among surgically treated @entity2 in elderly @entity0 with moderate or severe @entity9 compared to those without @entity9 (negative controls). MATERIALS AND METHODS: A retrospective case-controlled review (1:2) of elderly (>= 65 years) surgically treated @entity2 from 2011 to 2015 with moderate/severe @entity9 (according to American Heart @entity9 ) was conducted. @entity3 rates, 30 days and 1 year mortality were reviewed. RESULTS: Moderate/severe @entity9 was identified in 65 @entity2 cases and compared to 129 negative controls. @entity9 cases were significantly older with higher rates of @entity5 and @entity8 (p<0.05). Rates of any 30-day perioperative complication (74% vs. 37%, p<0.001) and severe non-cardiac 30-day perioperative complication (52% vs. 26%, p=0.002) were significantly higher among @entity9 cases compared to controls. Kaplan Meier estimates of 30-day mortality (14.7% vs. 4.2%, p<0.001) and 1-year mortality (46.8% vs. 14.1%, p<0.001) were significantly higher in @entity9 cases compared to controls. Multivariate analysis of severe 30-day postoperative @entity7 identified moderate/severe @entity9 (OR 4.02, p=0.001), @entity4 (OR 7.36, p=0.002) and @entity1 (OR 3.27, p=0.04) as independent predictors. Moderate/severe @entity9 (OR 3.38, p=0.03), @entity8 (OR 3.73, p=0.03) and @entity1 (OR 4.44, p=0.02) were independent predictors of 30-day mortality. Moderate/severe @entity9 (OR 5.79, p<0.001) and @entity1 (OR 3.39, p=0.02) were independent predictors of 1-year mortality. CONCLUSION: @entity6 is associated with a significantly increased risk of perioperative @entity7 , 30-day mortality and 1-year mortality in elderly @entity0 undergoing surgical treatment of @entity2 .

title: The effect of XXXX on elderly @entity2 outcomes: A case control study.

answer: @entity6


abstract: INTRODUCTION: @entity6 ( @entity9 ) is an established predictor of perioperative @entity7 following both cardiac and non-cardiac surgery. The purpose of this study was to evaluate the risk of mortality and perioperative @entity7 among surgically treated @entity2 in elderly @entity0 with moderate or severe @entity9 compared to those without @entity9 (negative controls). MATERIALS AND METHODS: A retrospective case-controlled review (1:2) of elderly (>= 65 years) surgically treated @entity2 from 2011 to 2015 with moderate/severe @entity9 (according to American Heart @entity9 ) was conducted. @entity3 rates, 30 days and 1 year mortality were reviewed. RESULTS: Moderate/severe @entity9 was identified in 65 @entity2 cases and compared to 129 negative controls. @entity9 cases were significantly older with higher rates of @entity5 and @entity8 (p<0.05). Rates of any 30-day perioperative complication (74% vs. 37%, p<0.001) and severe non-cardiac 30-day perioperative complication (52% vs. 26%, p=0.002) were significantly higher among @entity9 cases compared to controls. Kaplan Meier estimates of 30-day mortality (14.7% vs. 4.2%, p<0.001) and 1-year mortality (46.8% vs. 14.1%, p<0.001) were significantly higher in @entity9 cases compared to controls. Multivariate analysis of severe 30-day postoperative @entity7 identified moderate/severe @entity9 (OR 4.02, p=0.001), @entity4 (OR 7.36, p=0.002) and @entity1 (OR 3.27, p=0.04) as independent predictors. Moderate/severe @entity9 (OR 3.38, p=0.03), @entity8 (OR 3.73, p=0.03) and @entity1 (OR 4.44, p=0.02) were independent predictors of 30-day mortality. Moderate/severe @entity9 (OR 5.79, p<0.001) and @entity1 (OR 3.39, p=0.02) were independent predictors of 1-year mortality. CONCLUSION: @entity6 is associated with a significantly increased risk of perioperative @entity7 , 30-day mortality and 1-year mortality in elderly @entity0 undergoing surgical treatment of @entity2 .

title: The effect of @entity6 on elderly XXXX outcomes: A case control study.

answer: @entity2


abstract: Fluorescently labeled heavy meromyosin, @entity4 , and @entity5 were used to localize actin, @entity4 , and @entity5 , respectively, in permeabilized and living cells during the process of stress fiber reassembly, which occurred when cells were removed from @entity0 -depleting medium (20 mM @entity3 and 10 mM @entity1 ). In 80% of the cells recovering from @entity0 depletion, small, scattered plaques containing actin, @entity4 , and @entity5 were replaced by long, thin, periodic fibers within 5 minutes of removal of the inhibitors. These nascent stress fibers grew broader as recovery progressed, until they attained the thickness of stress fibers in control cells. In the other 20% of the cells, the scattered plaques aggregated within 5 minutes of reversal, and almost all the actin, @entity4 , and @entity5 in the cells became localized in one perinuclear aggregate, with a diameter of approximately 15-25 micron. As recovery progressed, all aggregates resembled rings, with diameters that increased at about 0.5 micron/minute and grew to as large as 70 micron in some giant cells. As the size of the rings increased, fibers radiated outward from them and sometimes spanned the diameter of the rings. The shape of the cells did not change during this time. By 1 hour after reversal, the rings were no longer present and all cells had networks of stress fibers. Indirect immunofluorescence techniques used to localize tubulin and @entity2 indicated that microtubules and intermediate filaments were not constituents of the rings, and the rings were not closely apposed to the substrate, judging from reflection contrast optics. The rapid rearrangement of attachment plaques into a perinuclear aggregate that spreads radially in the cytoplasm occurs at the same speed as fibroblast and chromosomal movement, but is unlike other types of intracytoplasmic motility.

title: Stress fiber reformation after XXXX depletion.

answer: @entity0


abstract: BACKGROUND: The Bethesda System of cervical cytologic findings introduced the term @entity7 ( @entity7 ) to cover the broad zone separating normal cytomorphology from definitive @entity5 ( @entity5 ). The management of @entity0 with @entity7 is particularly problematic as approximately 10% of @entity7 @entity0 develop SIL and 1 per 1000 develop @entity4 . METHODS: Our aim was to demonstrate the combined use of polymerase chain reaction for @entity3 ) typing and laser scanning cytometry for DNA content measurements in the subcategorization of @entity7 cases according to the risk for progression toward @entity1 . Liquid- based monolayer preparation (ThinPrep, Cytyc, Boston, MA) of the cytologic material was used for cytomorphologic analysis. DNA content measurements using laser scanning cytometry and direct sequencing of HPV using the consensus primers GP5+/GP6+ and MY09/MY11 were performed from the same material. RESULTS: Twelve of the 44 cases (27.2%) with @entity7 carried a high-risk HPV genome whereas only 3 of the 195 normal control cases (1.5%) showed positivity for a high-risk HPV genome. Six of 12 (50%) of the high-risk HPV-positive @entity7 cases presented isolated cells with a DNA content above 5c, whereas cells with a DNA content above 9c were found in 3 of 12 cases (25%) and were exclusively found in combination with high-risk HPV @entity2 . In these three cases, the histologic follow-up resulted in @entity6 (one case) and @entity6 (two cases). None of the other @entity7 or normal cases displayed DNA aneuploidy above 9c. They returned to normal cytology (within normal limits/benign cellular changes) in the follow-up. CONCLUSIONS: @entity3 typing and DNA content measurements may delineate a distinct group of @entity7 . Our preliminary data suggest that @entity7 cases with high-risk HPV positivity and with rare cells with abnormally high DNA content represent similar biologic features as high-grade SIL and are at elevated risk to develop @entity1 .

title: Determination of features indicating progression in atypical squamous cells with undetermined significance: XXXX typing and DNA ploidy analysis from liquid-based cytologic samples.

answer: @entity3


abstract: OBJECTIVE: @entity3 is a term used to describe a group of diseases in which there is an extracellular deposition of amorphous fibrillar proteins known as amyloid. The aim of this study was to present clinicopathological data from eight oral @entity3 @entity0 and a deep review of the literature about the disease. MATERIALS AND METHODS: A retrospective study was conducted based on the records of oral @entity3 @entity0 diagnosed in our institution between 1978 and 2012. The clinicopathological features and immunohistochemical (IHC) staining with anti-kappa and anti-lambda light chain antibodies were carried out and analyzed. RESULTS: Eight @entity0 were diagnosed with the disease; the tongue and @entity0 in their sixth decade of life were mostly affected. All lesions demonstrated apple-green birefringence and immunoreactivity for kappa-light chain, and four cases also showed lambda positivity. According to our series, four cases were diagnosed with @entity3 and four with @entity2 . Prognosis for the systemic ones was gloomy, but good for the localized ones, which was characterized by a slow pattern of deposition without evolution to systemic involvement. CONCLUSIONS: This study reinforces our knowledge about predilections, outcomes, and the importance of making a correct and quick diagnosis of @entity3 and shows the necessity of more studies detailing @entity3 predilection on a global scale. The importance and utility of IHC in the typing of the biochemical nature of @entity1 are becoming increasingly necessary for proper management of the @entity0 . Correct classification of the type of amyloid is important for treatment consequences. CLINICAL RELEVANCE: This article highlights the clinicopathological data of @entity0 with @entity3 affecting oral tissues and compare these new findings with other worldwide descriptions. Because of its rarity, such data are often unfamiliar to most clinicians and pathologists.

title: Involvement of oral tissues by XXXX : a literature review and report of eight new cases.

answer: @entity2


abstract: BACKGROUND: @entity2 is an autoimmune disease of multifactorial etiology with genetic predisposition. Its pathogenesis involved more than 100 genes. @entity5 gene can mediate various functions such as their costimulatory activity in the clonal expansion of T cells. The single nucleotide polymorphism, resulting in a non-conservative replacement of @entity3 to @entity4 (CD24v) precedes immediately GPI anchorage site (position   -1), determines @entity5 loss activity. CD24v has been associated with @entity1 and @entity2 in other populations. OBJECTIVE: To find the presence of CD24v in Mexican @entity0 with @entity2 . MATERIAL AND METHOD: A study of fenotyping of @entity5 v included 65 subjects, 32 cases ( @entity2 ): 28 @entity0 and 4 @entity0 ; and 32 controls: 9 @entity0 and 23 @entity0 ; cases and controls from @entity0 with @entity2 in National Medical Center 20 de Noviembre ISSSTE, Mexico City, services of Clinical Immunology and Rheumatology. RESULTS: In cases, 19 @entity0 had a wild homozygous genotype, 12 were heterozygous and only one @entity0 showed homozygous polymorphism. In controls, 17 showed wild heterozygous genotypes; 14 were heterozygous and 1 was found to be polymorphic homozygote. With odds ratio: 0.84 and chi-squared of 0.17; therefore there was no statistically significant difference. CONCLUSIONS: Study population showed that there is no statistically significant difference between @entity2 cases and controls with respect to the presence of CD24v.

title: [ XXXX and CD24v].

answer: @entity2


abstract: Current developments in tissue engineering and microtechnology fields allow the use of microfluidic biochip as microtools for in vitro investigations. In the present study, we describe the behavior of HepG2/ @entity7 cells cultivated in a @entity11 ( @entity12 ) microfluidic biochip coupled to a perfusion system. Cell culture in the microfluidic biochip for 96 h including 72 h of perfusion provoked a 24 h delay in cell growth compared to plate cultures. Inside the microfluidic biochip, few apoptosis, and @entity0 were detected along the culture and 3D cell organization was observed. Regarding the hepatic metabolism, @entity2 and @entity4 consumptions as well as albumin synthesis were maintained. A transcriptomic analysis performed at 96 h of culture using Affymetrix GeneChip demonstrated that 1,025 genes with a fold change above 1.8 were statistically differentially expressed in the microfluidic biochip cultures compared to plate cultures. Among those genes, phase I enzymes involved in the xenobiotic's metabolism such as the cytochromes P450 (CYP) 1A1/2, 2B6, 3A4, 3A5, and 3A7 were up-regulated. The @entity6 /2 up-regulation was associated with the appearance of @entity6 /2's activity evidenced by using EROD biotransformation assay. Several phase II enzymes such as sulfotransferases ( @entity8 and @entity14 ), @entity3 -glucuronyltransferase ( @entity9 , @entity13 ) and phase III transporters (such as @entity5 , @entity10 ) were also up-regulated. In conclusion, microfluidic biochip could and provide an important insight to exploring the xenobiotic's metabolism. Altogether, these results suggest that this kind of biochip could be considered as a new pertinent tool for predicting cell @entity1 and clearance of xenobiotics in vitro.

title: Improvement of HepG2/ XXXX cell functions in a microfluidic biochip.

answer: @entity7


abstract: PURPOSE: We examined whether bone marrow-derived dendritic cells (DCs) could induce antitumor immunity when a chemotherapeutic drug was added. METHODS: CT26 (a @entity1 @entity3 cell line syngeneic with BALB/c) and CT26-bearing @entity1 were treated with @entity4 ( @entity5 ) intraperitoneally (i.p.). Next, @entity1 immunized with a coinjection of DCs and @entity5 -treated CT26 (i.p.) were given an intradermal inoculation of CT26. Finally, CT26-bearing @entity1 were treated with @entity5 (i.p.) with or without DCs, given peritumorally. RESULTS: Although the inoculated @entity0 was not rejected in the control @entity1 , CT26 was rejected in 50% of the @entity1 injected with @entity5 alone. Apoptosis was observed in the @entity5 -treated CT26 cells in vitro and in vivo. Immunization with DCs and apoptotic CT26 cells, but not with apoptotic CT26 alone, gave protection against @entity0 challenge in 7 of 13 @entity1 . A significantly higher level of cytotoxic T-cell activity and @entity2 production was seen in the protected @entity1 . When @entity5 (i.p.) treatment was followed by peritumoral DC injection in the CT26-bearing @entity1 , remarkable therapeutic effects were observed. CONCLUSION: DCs can collaborate with chemotherapy-induced @entity0 cells and elicit improved antitumor immunity, probably through the acquisition of @entity0 -associated antigens from @entity0 cells.

title: Dendritic cells coinjected with XXXX cells treated with an anticancer drug to induce @entity0 rejection.

answer: @entity0