abstract: UNASSIGNED: @entity3 10993-5 provides one of the accepted standards for testing the biotoxicity of new materials. All of the recommended test procedures rely upon the uptake or metabolism of dye by living cells. Results of direct contact tests can be potentially compromised by interaction or adsorption of the dye or its metabolic products. Therefore, the aim of the current study was to validate the use of the eGFP signal of transfected NIH-3T3 fibroblasts with the results of the @entity0 test in order to provide a test procedure that is very close to the @entity3 10993-5 but has the advantage of not relying on the addition of dye. Our tests show that the @entity0 assay detects @entity1 in the eGFP NIH-3T3 cells at least as well as in the L929 cells. To facilitate the validation, we chose to integrate the fluorescence measurements into the @entity0 test procedure. To that end, an additional washing step was introduced. Additionally, medium without @entity2 red was used, resulting in a very high correlation of both measurements. Without these modifications, the fluorescence test was comparable to the @entity0 test in its ability to detect the cytotoxic potential of substances; however, it did result in slightly elevated IC50 concentrations. As the results of both tests correlated highly, measurement of the eGFP signal appears to present a reliable tool for detecting @entity1 of materials in line with the @entity3 10993-5 norm with the advantage of avoiding the addition of dyes and the subsequent potential interaction with test materials.    2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.

title: Validation of eGFP fluorescence intensity for testing in vitro XXXX according to @entity3 10993-5.

answer: @entity1


abstract: UNASSIGNED: @entity3 10993-5 provides one of the accepted standards for testing the biotoxicity of new materials. All of the recommended test procedures rely upon the uptake or metabolism of dye by living cells. Results of direct contact tests can be potentially compromised by interaction or adsorption of the dye or its metabolic products. Therefore, the aim of the current study was to validate the use of the eGFP signal of transfected NIH-3T3 fibroblasts with the results of the @entity0 test in order to provide a test procedure that is very close to the @entity3 10993-5 but has the advantage of not relying on the addition of dye. Our tests show that the @entity0 assay detects @entity1 in the eGFP NIH-3T3 cells at least as well as in the L929 cells. To facilitate the validation, we chose to integrate the fluorescence measurements into the @entity0 test procedure. To that end, an additional washing step was introduced. Additionally, medium without @entity2 red was used, resulting in a very high correlation of both measurements. Without these modifications, the fluorescence test was comparable to the @entity0 test in its ability to detect the cytotoxic potential of substances; however, it did result in slightly elevated IC50 concentrations. As the results of both tests correlated highly, measurement of the eGFP signal appears to present a reliable tool for detecting @entity1 of materials in line with the @entity3 10993-5 norm with the advantage of avoiding the addition of dyes and the subsequent potential interaction with test materials.    2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.

title: Validation of eGFP fluorescence intensity for testing in vitro @entity1 according to XXXX 10993-5.

answer: @entity3


abstract: OBJECT: The current study was undertaken to evaluate the @entity1 control rate and functional outcome after Gamma Knife surgery (GKS) in @entity0 with a @entity4 . The conditions associated with the development of @entity2 after radiosurgery were scrutinized. METHODS: The authors reviewed the clinical records and radiological data in 22 consecutive @entity0 who received GKS for a @entity4 . The median @entity1 volume was 4.1 ml (0.2-12.0 ml), and the mean @entity1 margin dose was 13.3 +/- 1.3 Gy at an isodose line of 49.9 +/- 0.6% (mean +/- standard deviation). The median clinical follow-up period was 46 months (range 24-89 months), and the median length of imaging follow-up was 37 months (range 24-79 months). RESULTS: @entity1 growth control was achieved in 21 (95%) of the 22 @entity0 . @entity3 responded best to radiosurgery, with two thirds of @entity0 showing improvement. However, only one third of @entity0 with @entity5 improved. Six @entity0 (27%) experienced new or worsening @entity2 after GKS. Ten @entity0 (46%) showed @entity1 expansion after radiosurgery, and nine of these also showed central enhancement loss. Loss of central enhancement, @entity1 expansion, and a @entity1 in a cavernous sinus were found to be significantly related to the emergence of @entity2 . CONCLUSIONS: The use of GKS to treat @entity4 resulted in a high rate of @entity1 control and functional improvement. @entity2 are bothersome complications of radiosurgery, and @entity1 expansion in a cavernous sinus after radiosurgery appears to be the proximate cause of the complication. Loss of central enhancement could be used as a warning sign of @entity2 , and for this vigilant @entity0 monitoring is required.

title: Gamma Knife surgery and XXXX : is it possible to preserve @entity2 ?

answer: @entity4


abstract: OBJECT: The current study was undertaken to evaluate the @entity1 control rate and functional outcome after Gamma Knife surgery (GKS) in @entity0 with a @entity4 . The conditions associated with the development of @entity2 after radiosurgery were scrutinized. METHODS: The authors reviewed the clinical records and radiological data in 22 consecutive @entity0 who received GKS for a @entity4 . The median @entity1 volume was 4.1 ml (0.2-12.0 ml), and the mean @entity1 margin dose was 13.3 +/- 1.3 Gy at an isodose line of 49.9 +/- 0.6% (mean +/- standard deviation). The median clinical follow-up period was 46 months (range 24-89 months), and the median length of imaging follow-up was 37 months (range 24-79 months). RESULTS: @entity1 growth control was achieved in 21 (95%) of the 22 @entity0 . @entity3 responded best to radiosurgery, with two thirds of @entity0 showing improvement. However, only one third of @entity0 with @entity5 improved. Six @entity0 (27%) experienced new or worsening @entity2 after GKS. Ten @entity0 (46%) showed @entity1 expansion after radiosurgery, and nine of these also showed central enhancement loss. Loss of central enhancement, @entity1 expansion, and a @entity1 in a cavernous sinus were found to be significantly related to the emergence of @entity2 . CONCLUSIONS: The use of GKS to treat @entity4 resulted in a high rate of @entity1 control and functional improvement. @entity2 are bothersome complications of radiosurgery, and @entity1 expansion in a cavernous sinus after radiosurgery appears to be the proximate cause of the complication. Loss of central enhancement could be used as a warning sign of @entity2 , and for this vigilant @entity0 monitoring is required.

title: Gamma Knife surgery and @entity4 : is it possible to preserve XXXX ?

answer: @entity2


abstract: @entity3 is a @entity2 that has received considerable attention in allopathic medicine over the past decades. However, it is clear that, to date, pharmacological and surgical interventions do not fully address symptoms of @entity5 and @entity0 ' quality of life. As both an alternative therapy and as an adjuvant to conventional approaches, several types of rhythmic movement (e.g., movement strategies, dance, tandem biking, and Tai Chi) have shown improvements to motor symptoms, lower limb control, and postural stability in @entity0 with @entity5 (1-6). However, while these programs are increasing in number, still little is known about the neural mechanisms underlying motor improvements attained with such interventions. Studying limb motor control under task-specific contexts can help determine the mechanisms of rehabilitation effectiveness. Both internally guided (IG) and externally guided (EG) movement strategies have evidence to support their use in rehabilitative programs. However, there appears to be a degree of differentiation in the neural substrates involved in IG vs. EG designs. Because of the potential task-specific benefits of rhythmic training within a rehabilitative context, this report will consider the use of IG and EG movement strategies, and observations produced by functional magnetic resonance imaging and other imaging techniques. This review will present findings from lower limb imaging studies, under IG and EG conditions for populations with and without @entity4 . We will discuss how these studies might inform @entity4 rehabilitation (in the form of rhythmic, music-based movement training) and highlight research gaps. We believe better understanding of lower limb neural activity with respect to @entity1 during rhythmic IG and EG movement will facilitate the development of novel and effective therapeutic approaches to mobility limitations and postural instability.

title: Context-Dependent Neural Activation: Internally and Externally Guided Rhythmic Lower Limb Movement in Individuals With and Without XXXX .

answer: @entity2


abstract: Researches show that @entity4 have important effects on migration of endothelial cells and endothelial protection in @entity0 . Endothelial progenitor cells (EPCs) as a progenitor cell type that can differentiate into endothelial cells, have a critical role in angiogenesis and endothelial protection. The relationship between @entity1 and the functions of EPCs has animated much interest and controversy. In this study, we investigated the angiogenic and migratory functions of EPCs after treatment by @entity2 ( @entity3 ) and the molecular mechanisms as well. We found that @entity3 treatment enhanced the incorporation of EPCs into tubular structures formed by HUVECs and the migratory activity of EPCs in the transwell assay dose dependently. Moreover, microarray analysis was performed to explore how @entity3 changes the gene expression profiles of EPCs. We found 346 differentially expressed genes in @entity1 -treated EPCs. Angiogenesis-related genes like @entity5 , @entity7 , @entity6 , and @entity8 were identified to be regulated upon @entity3 treatment. Furthermore, the enhanced angiogenic and migratory abilities of EPCs after @entity3 treatment were inhibited by @entity5 -siRNA transfection. In conclusion, our findings suggest that @entity3 markedly enhances the vessel forming ability and migration capacity of EPCs. @entity5 signaling may be a possible pathway in this process.

title: @entity1 Modulates Functions of Endothelial Progenitor Cells through Activated XXXX Signaling.

answer: @entity5


abstract: Researches show that @entity4 have important effects on migration of endothelial cells and endothelial protection in @entity0 . Endothelial progenitor cells (EPCs) as a progenitor cell type that can differentiate into endothelial cells, have a critical role in angiogenesis and endothelial protection. The relationship between @entity1 and the functions of EPCs has animated much interest and controversy. In this study, we investigated the angiogenic and migratory functions of EPCs after treatment by @entity2 ( @entity3 ) and the molecular mechanisms as well. We found that @entity3 treatment enhanced the incorporation of EPCs into tubular structures formed by HUVECs and the migratory activity of EPCs in the transwell assay dose dependently. Moreover, microarray analysis was performed to explore how @entity3 changes the gene expression profiles of EPCs. We found 346 differentially expressed genes in @entity1 -treated EPCs. Angiogenesis-related genes like @entity5 , @entity7 , @entity6 , and @entity8 were identified to be regulated upon @entity3 treatment. Furthermore, the enhanced angiogenic and migratory abilities of EPCs after @entity3 treatment were inhibited by @entity5 -siRNA transfection. In conclusion, our findings suggest that @entity3 markedly enhances the vessel forming ability and migration capacity of EPCs. @entity5 signaling may be a possible pathway in this process.

title: XXXX Modulates Functions of Endothelial Progenitor Cells through Activated @entity5 Signaling.

answer: @entity1


abstract: OBJECTIVE: To evaluate feasibility, functional outcome, and disease control of endoscopic surgery and irradiation in @entity0 with @entity4 of the supraglottic larynx. DESIGN: Prospective, single-arm, phase 2 multi-institutional trial. SETTING: Southwest Oncology Group trial S9709. @entity0 : Thirty-four @entity0 diagnosed as having stage I, stage II, or selected stage III (T1-2N1M0) supraglottic @entity2 enrolled from September 15, 1997, to December 1, 2001. INTERVENTIONS: Transoral supraglottic laryngectomy by @entity3 laser followed by planned postoperative radiotherapy. MAIN OUTCOME MEASURES: Three-year progression-free survival, proportion of @entity0 requiring tracheostomy as a result of surgery, and time to adequate oral intake. RESULTS: All 34 @entity0 underwent surgery without major protocol deviation. Thirty-two @entity0 (94%) completed planned postoperative radiotherapy without major deviation. At the time of analysis, only 1 @entity0 (3%) had documented local disease recurrence at the primary disease site and required salvage total laryngectomy, and 2 @entity0 (6%) had documented regional recurrence and required salvage neck dissection. Estimated 3-year progression-free survival and overall survival were 79% and 88%, respectively. No subjects required tracheostomy as a direct consequence of endoscopic resection. @entity0 who required tracheostomy before endoscopic resection due to either obstructive @entity1 bulk or unfavorable anatomy that precluded safe intubation (4 @entity0 [12%]) were all decannulated in the early postoperative period (<or=1 week). Of the 34 @entity0 , 24 (71%) recovered adequate oral intake (no longer requiring supplemental intravenous fluids or tube feeding) in the early postoperative period (before hospital discharge) (median time, 2 days; range, 1-7 days), with an additional 7 @entity0 (21%) achieving delayed recovery (2.7-9.8 months). Three @entity0 (9%) remained dependent on a feeding tube at last documented follow-up. CONCLUSIONS: Transoral endoscopic @entity3 laser excision of supraglottic @entity1 combined with postoperative radiotherapy appears feasible in a multi-institutional setting, with reasonable disease control. Although timing was variable, most @entity0 recovered adequate swallowing in the early postoperative period.

title: Transoral XXXX laser supraglottic laryngectomy and irradiation in stage I, II, and III squamous cell carcinoma of the supraglottic larynx: report of Southwest Oncology Group Phase 2 Trial S9709.

answer: @entity3


abstract: BACKGROUND: @entity4 ( @entity4 ) is the most important complication and the leading cause of @entity3 in @entity0 with @entity1 ( @entity1 ). @entity5 is an important modifiable risk factor for @entity4 . Statins are the first line drugs for the treatment of @entity5 in @entity6 . Comparative studies between different statins are available but different doses of the same @entity7 have not been compared in our population. The objective of this study is to compare mean reduction in serum @entity9 level after using 5mg and 10mg of @entity8 among @entity1 @entity0 with @entity5 . This study will help finding lowest effective dose of @entity8 to achieve internationally set low density lipoprotein @entity2 ( @entity9 ) goals. METHODS: A total of 82 @entity0 with @entity1 having fasting @entity9 levels equal or more than 100mg/dl were randomly allocated into two groups with 41 @entity0 in each group. Baseline fasting serum LCL-C levels were obtained in all @entity0 . Group A received 5mg while group B received 10mg of @entity8 daily at night. After 6 weeks, fasting @entity9 levels were obtained and analysed to compare the mean  SD reduction of @entity9 levels in both groups. RESULTS: Baseline mean  SD @entity9 levels in group A and group B were 134.12  30.02 and 143.49  32.01 respectively (p 0.176). Follow up mean  SD @entity9 levels were 81.59  28.47 and 83.24  36.06respectively (p 0.818). Mean  SD reduction in @entity9 levels from baseline levels in group A and group B were 52.51  19.49 and 60.20  24.09 (p 0.116). CONCLUSION: @entity8 5mg is as effective as 10mg in reducing the @entity9 levels in type 2 @entity1 @entity0 with @entity5 .

title: EFFICACY OF 5 MG AND 10 MG XXXX IN TYPE-2 DIABETES MELLITUS WITH HYPERCHOLESTEROALEMIA.

answer: @entity8


abstract: BACKGROUND/PURPOSE: @entity1 screening using low-dose computed tomography (CT) has been reported to reduce @entity1 -specific mortality for smokers at high risk. However, despite different characteristics of @entity1 in Asia, there are few data concerning this specific population for screening. We aim to analyze the performance of @entity1 screening with low-dose CT concurrent with chest radiography in Taiwan, with reference to international experience. METHODS: During the 1-year period from January 2012 to December 2012, we conducted a retrospective, single-center population-based screening program for @entity1 in the setting of annual medical examinations. @entity0 were asymptomatic adults without prior history of any @entity2 . Low-dose CT and chest radiography were offered to all individuals. Baseline CT evaluations were defined as positive if any noncalcified nodule>= 4  mm in diameter, which were then classified as solid, pure ground-glass or partial ground-glass opacity. RESULTS: Of 3339 individuals, we detected 34 @entity2 , yielding an overall @entity2 detection rate of 1.02%. There was a particularly high @entity2 detection rate of 6.2% (8/129) in the high-risk group aged younger than 50  years with a positive family history of all types of @entity2 in first-degree relatives. @entity3 accounted for 88% (30/34) of @entity2 and 99% of them were early-stage (including @entity4 and Stage I). The probability of @entity2 was significant higher in nodules with interval growth (odds ratio 257.89, p  =  0.0002). There was no significant difference in the probability of @entity2 between ground glass opacity nodules and solid nodules (odds ratio 1.16, p=0.72). Of all screen-detected @entity2 , 61.76% (21/34) were chest radiographically occult. CONCLUSION: Low-dose CT is effective to detect early @entity1 . Further establishment of selection criteria for @entity1 screening, specifically for Asian individuals, is definitely warranted.

title: XXXX screening with low-dose computed tomography: Experiences from a tertiary hospital in Taiwan.

answer: @entity1


abstract: BACKGROUND: Family members of @entity3 workers are at increased risk of @entity4 ( @entity4 ). Although the hazard is established, the magnitude of the risk is uncertain, and it is unclear whether risk is also increased for other @entity2 . Few cohort studies have been reported. OBJECTIVE: The "Eternit" factory of Casale Monferrato (Italy), active from 1907 to 1986, was among the most important Italian plants producing @entity3 -cement (AC) goods. In this article we present updated results on mortality and @entity4 incidence in the wives of workers at the factory. METHODS: We studied a cohort of 1,780 @entity0 , each married to an AC worker during his employment at the factory but not personally occupationally exposed to @entity3 . Cohort membership was defined starting from the marital status of each worker, which was ascertained in 1988 from the Registrar's Office in the town where workers lived. At the end of follow-up (April 2003), 67% of @entity0 were alive, 32.3% dead, and 0.7% lost to follow-up. Duration of exposure was computed from the husband's period of employment. Latency was the interval from first exposure to the end of follow-up. RESULTS: The standardized mortality ratio (SMR) for @entity2 [21 observed vs. 1.2 expected; SMR = 18.00; 95% confidence interval (CI), 11.14-27.52] was significantly increased. @entity1 was not increased (12 observed vs. 10.3 expected; SMR = 1.17; 95% CI, 0.60-2.04). Eleven incident cases of pleural @entity4 were observed (standardized incidence ratio = 25.19; 95% CI, 12.57-45.07). CONCLUSIONS: Household exposure, as experienced by these AC workers' wives, increases risk for pleural @entity4 but not for @entity1 .

title: @entity2 mortality and incidence of mesothelioma in a cohort of wives of XXXX workers in Casale Monferrato, Italy.

answer: @entity3


abstract: BACKGROUND: Family members of @entity3 workers are at increased risk of @entity4 ( @entity4 ). Although the hazard is established, the magnitude of the risk is uncertain, and it is unclear whether risk is also increased for other @entity2 . Few cohort studies have been reported. OBJECTIVE: The "Eternit" factory of Casale Monferrato (Italy), active from 1907 to 1986, was among the most important Italian plants producing @entity3 -cement (AC) goods. In this article we present updated results on mortality and @entity4 incidence in the wives of workers at the factory. METHODS: We studied a cohort of 1,780 @entity0 , each married to an AC worker during his employment at the factory but not personally occupationally exposed to @entity3 . Cohort membership was defined starting from the marital status of each worker, which was ascertained in 1988 from the Registrar's Office in the town where workers lived. At the end of follow-up (April 2003), 67% of @entity0 were alive, 32.3% dead, and 0.7% lost to follow-up. Duration of exposure was computed from the husband's period of employment. Latency was the interval from first exposure to the end of follow-up. RESULTS: The standardized mortality ratio (SMR) for @entity2 [21 observed vs. 1.2 expected; SMR = 18.00; 95% confidence interval (CI), 11.14-27.52] was significantly increased. @entity1 was not increased (12 observed vs. 10.3 expected; SMR = 1.17; 95% CI, 0.60-2.04). Eleven incident cases of pleural @entity4 were observed (standardized incidence ratio = 25.19; 95% CI, 12.57-45.07). CONCLUSIONS: Household exposure, as experienced by these AC workers' wives, increases risk for pleural @entity4 but not for @entity1 .

title: XXXX mortality and incidence of mesothelioma in a cohort of wives of @entity3 workers in Casale Monferrato, Italy.

answer: @entity2


abstract: OBJECTIVES: The characteristics of the @entity0 may favour the appearance of complications. Taking into account the high morbimortality of the process, we believe that is convenient knowing main features of @entity4 in postoperatory in our surgical area. METHODS: We have retrospectively studied the radical cystectomies having @entity2 . Variables considered can be classified in four main categories: @entity0 physiology, operation, @entity4 and morbimortality. RESULTS: During considered time, 9 of 80 cystectomies showed complications related with @entity4 (11,25%). Except one @entity0 , 44-year-old, all others where 50-year-old or older males. 5 surgeries were curative and 4 palliative. 5 of the @entity4 appeared during first week. Initial mechanism was dehiscence, @entity1 or @entity3 (6.2 and 1 respectivelly). In 6 @entity0 , origin was ureteroileal anastomosis, 2 intestinal anastomosis and I cutaneous ureterostomy. 3 of 9 @entity0 died due to @entity4 . CONCLUSIONS: The incidence of @entity5 during the immediate post operative period of radical cystectomy is high and, often, difficult to diagnose. In @entity0 subjected to this surgery as a palliative method, possibility of showing complications is higher. To correct this medical profile, early intervention is fundamental, determining @entity0 prognosis.

title: [Acute XXXX after radical cystectomy. Experience at our hospital and bibliographic review].

answer: @entity4


abstract: BACKGROUND: Prognostic classification approaches are commonly used in clinical practice to predict health outcomes. However, there has been limited focus on use of the general approach for predicting costs. We applied a grouping algorithm designed for large-scale data sets and multiple prognostic factors to investigate whether it improves cost prediction among older Medicare beneficiaries diagnosed with @entity2 . METHODS: We analysed the linked Surveillance, Epidemiology and End Results (SEER)-Medicare data, which included data from 2000 through 2009 for @entity0 diagnosed with @entity2 between 2000 and 2007. We split the survival data into two data sets (D0 and D1) of equal size. We trained the classifier of the Grouping Algorithm for @entity1 Data (GACD) on D0 and tested it on D1. The prognostic factors included @entity1 stage, age, race and performance status proxies. We calculated the average difference between observed D1 costs and predicted D1 costs at 5  years post-diagnosis with and without the GACD. RESULTS: The sample included 110,843 @entity0 with @entity2 . The median age of the sample was 74  years, and 10  % were African American. The average difference (mean absolute error [MAE]) per @entity0 between the real and predicted total 5-year cost was US 41,525 (MAE US 41,790; 95  % confidence interval [CI] US 41,421-42,158) with the GACD and US 43,113 (MAE US 43,639; 95  % CI US 43,062-44,217) without the GACD. The 5-year cost prediction without grouping resulted in a sample overestimate of US 79,544,508. CONCLUSION: The grouping algorithm developed for complex, large-scale data improves the prediction of 5-year costs. The prediction accuracy could be improved by utilization of a richer set of prognostic factors and refinement of categorical specifications.

title: Cost Prediction Using a Survival Grouping Algorithm: An Application to Incident XXXX Cases.

answer: @entity2


abstract: OBJECTIVE: Although complement fixation is not commonly thought to be part of the pathogenesis of @entity2 ( @entity2 ), hypocomplementemia has been associated with @entity2 . We hypothesized that hypocomplementemia in @entity2 might indicate the presence of overlap disease. We investigated if @entity2 @entity0 with hypocomplementemia had more features of overlap disease than those with normal complement levels. METHODS: Study subjects consisted of those enrolled in the Canadian @entity4 Research Group Registry. @entity0 were divided into 2 groups: those with normal complement levels (normal C3 and C4) and those with hypocomplementemia (low C3 or C4). Evidence of overlap disease was defined as physician reports of other specific @entity1 . Autoantibodies were assayed. Differences in rates of concomitant diseases and in antibody profiles were compared between groups. RESULTS: Our study included 321 @entity0 (88% @entity0 , mean age 56 +/- 13 yrs, mean disease duration 11 +/- 9 yrs). Of these, 276 (86%) had normal complements and 45 (14%) had hypocomplementemia. @entity0 with hypocomplementemia were significantly more likely to have physician-reported inflammatory @entity5 (27% vs 12%; p < 0.008) and @entity3 (11% vs 2%; p < 0.011) than those with normal complement. There was also a trend toward more antichromatin antibodies (18% vs 9%; p = 0.051) in @entity0 with hypocomplementemia compared to normals. CONCLUSION: Hypocomplementemia may identify a particular subgroup of @entity2 @entity0 who have overlap disease.

title: Hypocomplementemia in XXXX --clinical and serological correlations.

answer: @entity2


abstract: PURPOSE: To compare the impact, in terms of survival, of complete cytoreduction after @entity3 ( @entity3 ) and @entity4 ( @entity4 ) in @entity0 with advanced @entity1 (International Federation of Gynecology and Obstetrics stages III-IV) by reviewing the recent literature. METHODS: A search of the PubMed database during the last 7  years (2008-2014) was carried out looking for studies specifically showing data on median survival or disease-free survival after complete cytoreduction after either @entity3 or @entity4 . RESULTS: We found 24 publications including 14,182 @entity0 with stages III to IV @entity1 . A total of 11871 @entity0 (83.7  %) underwent @entity3 and 2311 (16.3  %) underwent interval debulking after neoadjuvant chemotherapy. A total of 4684 @entity0 (33  %) were considered completely resected with microscopic @entity2 . After @entity3 , the weighted average of median overall and progression-free survival was 43 and 17  months, respectively, for the whole group. After @entity4 , median and progression-free survival were 33 and 14  months. The rate of complete cytoreduction after @entity3 was inferior to the obtained in @entity0 with @entity4 (27 vs. 59  %). However, the median survival in @entity0 with complete cytoreduction with primary cytoreduction was 23  months longer than in the group with interval debulking (69 vs. 45  months). CONCLUSIONS: Complete cytoreduction after @entity4 yields a inferior outcome in terms of median survival than @entity3 of almost 2  years. Despite the higher rate of complete resection, @entity4 apparently fails to improve the results obtained by primary debulking.

title: What Should We Expect After a Complete Cytoreduction at the Time of Interval or Primary Debulking Surgery in Advanced XXXX ?

answer: @entity1


abstract: The first aim of this study was to determine the prevalence of @entity4 in newborn @entity0 treated by the public health system in Porto Alegre, a city in southern Brazil, using neonatal screening for @entity3 -specific IgM. The second aim was to investigate whether the cases detected by this approach could have been identified by the prenatal screening for antibodies to @entity3 that was performed in the same population. A fluorometric assay was used to analyse @entity3 -specific IgM in filter paper specimens obtained from newborn @entity0 for routine screening for @entity1 . When the specific IgM was positive, serum samples from the @entity0 and the mother were requested for confirmatory serological testing, and the @entity0 underwent clinical examination. Among 10 000 @entity0 screened for @entity3 -specific IgM, seven filter paper samples were positive, and @entity4 was confirmed in six @entity0 . The prevalence of IgM specific for @entity3 was 6/10 000 [95% CI 2/10 000, 13/10 000]. One infected @entity0 had already been identified in the maternity ward before birth, three had been identified by maternal serology at delivery, and two @entity0 with @entity4 were identified solely through neonatal screening. Although four mothers of the @entity0 with @entity4 received prenatal care, and three mothers had one or two serological tests for T. gondii-specific antibodies (one at first trimester, one at first and second trimesters, and the other at second and third trimesters), they were not identified during pregnancy as infected. Neonatal screening identified cases of @entity2 not detected by obtaining only one or two serum samples from pregnant @entity0 for @entity3 serology, mainly when @entity2 was acquired and transmitted in late pregnancy. Maternal serology at delivery and neonatal screening were especially useful in the identification of @entity0 with @entity4 when the mother did not receive regular prenatal serological testing or prenatal care.

title: @entity4 : late pregnancy XXXX detected by neonatal screening and maternal serological testing at delivery.

answer: @entity2


abstract: The first aim of this study was to determine the prevalence of @entity4 in newborn @entity0 treated by the public health system in Porto Alegre, a city in southern Brazil, using neonatal screening for @entity3 -specific IgM. The second aim was to investigate whether the cases detected by this approach could have been identified by the prenatal screening for antibodies to @entity3 that was performed in the same population. A fluorometric assay was used to analyse @entity3 -specific IgM in filter paper specimens obtained from newborn @entity0 for routine screening for @entity1 . When the specific IgM was positive, serum samples from the @entity0 and the mother were requested for confirmatory serological testing, and the @entity0 underwent clinical examination. Among 10 000 @entity0 screened for @entity3 -specific IgM, seven filter paper samples were positive, and @entity4 was confirmed in six @entity0 . The prevalence of IgM specific for @entity3 was 6/10 000 [95% CI 2/10 000, 13/10 000]. One infected @entity0 had already been identified in the maternity ward before birth, three had been identified by maternal serology at delivery, and two @entity0 with @entity4 were identified solely through neonatal screening. Although four mothers of the @entity0 with @entity4 received prenatal care, and three mothers had one or two serological tests for T. gondii-specific antibodies (one at first trimester, one at first and second trimesters, and the other at second and third trimesters), they were not identified during pregnancy as infected. Neonatal screening identified cases of @entity2 not detected by obtaining only one or two serum samples from pregnant @entity0 for @entity3 serology, mainly when @entity2 was acquired and transmitted in late pregnancy. Maternal serology at delivery and neonatal screening were especially useful in the identification of @entity0 with @entity4 when the mother did not receive regular prenatal serological testing or prenatal care.

title: XXXX : late pregnancy @entity2 detected by neonatal screening and maternal serological testing at delivery.

answer: @entity4


abstract: BACKGROUND: Young adult smokers are a challenging group to engage in smoking cessation interventions. With wide reach and engagement among users, Facebook offers opportunity to engage young @entity0 in socially supportive communities for quitting smoking and sustaining abstinence. OBJECTIVE: We developed and tested initial efficacy, engagement, and acceptability of the @entity1 Status Project, a smoking cessation intervention for young adults delivered within Facebook. METHODS: The intervention was based on the US Public Health Service Clinical Practice Guidelines and the Transtheoretical Model and enrolled @entity0 into study-run 3-month secret Facebook groups matched on readiness to quit smoking. Cigarette smokers (N=79) aged 18-25, who used Facebook on most days, were recruited via Facebook. All @entity0 received the intervention and were randomized to one of three monetary incentive groups tied to engagement (commenting in groups). Assessments were completed at baseline, 3-, 6-, and 12-months follow-up. Analyses examined retention, smoking outcomes over 12 months (7-day point prevalence abstinence, >= 50% reduction in cigarettes smoked, quit attempts and strategies used, readiness to quit), engagement, and satisfaction with the intervention. RESULTS: Retention was 82% (65/79) at 6 months and 72% (57/79) at 12 months. From baseline to 12-months follow-up, there was a significant increase in the proportion prepared to quit (10/79, 13%; 36/79, 46%, P<.001). Over a third (28/79, 35%) reduced their cigarette consumption by 50% or greater, and 66% (52/79) made at least one 24-hour quit attempt during the study. In an intent-to-treat analysis, 13% (10/79) self-reported 7-day abstinence (6/79, 8% verified biochemically) at 12-months follow-up. In their quit attempts, 11% (9/79) used a @entity2 replacement therapy approved by the Food and Drug Administration, while 18% (14/79) used an electronic @entity2 delivery system to quit (eg, electronic cigarette). A majority (48/79, 61%) commented on at least one Facebook post, with more commenting among those with biochemically verified abstinence at 3 months (P=.036) and those randomized to receive a personal monetary incentive (P=.015). Over a third of @entity0 (28/79, 35%) reported reading most or all of the Facebook posts. Highest acceptability ratings of the intervention were for post ease (57/79, 72%) and thinking about what they read (52/79, 66%); 71% (56/79) recommended the program to others. Only 5 @entity0 attended the optional cognitive-behavioral counseling sessions, though their attendance was high (6/7 sessions overall) and the sessions were rated as easy to understand, useful, and helpful (all 90-100% agreed). CONCLUSIONS: A Facebook quit smoking intervention is attractive and feasible to deliver, and early efficacy data are encouraging. However, the 1.5-fold greater use of electronic cigarettes over @entity2 replacement products for quitting is concerning.

title: Feasibility and Quit Rates of the XXXX Status Project: A Facebook Smoking Cessation Intervention for Young Adults.

answer: @entity1


abstract: BACKGROUND: Thoracoscopic anterior release has been shown that it can effectively improve spinal flexibility in animal and @entity0 cadaveric studies, and has been advocated for use in @entity0 with @entity3 . This prospective case series aims to investigate the improvement of the spinal flexibility and the effectiveness in deformity correction by anterior thoracoscopic release and posterior spinal fusion. METHODS: Eleven @entity0 with stiff @entity2 underwent anterior thoracoscopic release followed by posterior instrumentation. The average number of discs excised was five. Spinal flexibility was assessed by the fulcrum bending technique. Cobb angle before and after the anterior release was compared. RESULTS: The @entity0 were followed for an average of 5.6 years (range 2.2 to 8.1 years). Fulcrum bending flexibility was increased from 39% before the thoracoscopic anterior spinal release to 54% after the release. The average Cobb angle before anterior release was 74 degrees on the standing radiograph and 45 degrees with the fulcrum-bending radiograph. This reduced to 34 degrees on the fulcrum-bending radiograph after the release, and highly corresponded to the 31 degrees measured at the post-operative standing radiograph. CONCLUSION: It was demonstrated in @entity0 with stiff @entity2 that thoracoscopic anterior spinal release can effectively improve the spinal flexibility and increase the correction of the @entity1 .

title: Treatment of stiff XXXX by thoracoscopic anterior release combined with posterior instrumentation and fusion.

answer: @entity2


abstract: BACKGROUND: Efforts to gather genomic evidence for the processes of gene evolution are ongoing, and are closely coupled to improved gene annotation methods. Such annotation is complicated by the occurrence of disrupted mRNAs (dmRNAs), harbouring frameshifts and premature stop codons, which can be considered indicators of decay into pseudogenes. RESULTS: We have derived a procedure to annotate dmRNAs, and have applied it to @entity0 data. Subsequences are generated from parsing at key frame-disruption positions and are required to align significantly within any original protein homology. We find 419 high-quality @entity0 dmRNAs (3% of total). Significant dmRNA subpopulations include: @entity1 -finger-containing transcription factors with long disrupted exons, and antisense homologies to distal genes. We analysed the distribution of initial frame disruptions in dmRNAs with respect to positions of: (i) protein domains, (ii) alternatively-spliced exons, and (iii) regions susceptible to @entity2 ( @entity2 ). We find significant avoidance of protein-domain disruption (indicating a selection pressure for this), and highly significant overrepresentation of disruptions in alternatively-spliced exons, and 'non- @entity2 ' regions. We do not find any evidence for evolution of novelty in protein structures through frameshifting. CONCLUSION: Our results indicate largely negative selection pressures related to frame disruption during gene evolution.

title: Frame disruptions in XXXX mRNA transcripts, and their relationship with splicing and protein structures.

answer: @entity0


abstract: PURPOSE: @entity0 undergoing chemotherapy often fail to develop robust responses to influenza vaccination. Compared to standard-dose influenza vaccine ( @entity1 ), @entity2 ( @entity3 ) has shown improved immunogenicity and protection against @entity2 in adults 65 years and older. This study compared the immunogenicity and tolerability of @entity3 to @entity1 in adults younger than 65 years of age receiving chemotherapy. METHODS: This double-blind study randomized @entity0 receiving chemotherapy to vaccination with either @entity1 or @entity3 influenza vaccine. Hemagglutination inhibition assays (HAI) were performed prior to and 4 weeks after vaccination. HAI were summarized as geometric mean titers (GMT), seroconversion rates, and seroprotection rates. RESULTS: A total of 105 subjects were enrolled in the trial (51 received @entity1 and 54 received @entity3 ). Subjects were well matched for demographic and medical conditions. Both vaccines were well tolerated with no SAEs. Of the 100 subjects with evaluable data, seroconversion rates for all 3 influenza antigens _ post-vaccination GMTs for H3N2 _ B strains were significantly improved with @entity3 compared to @entity1 . Seroprotection was excellent and equivalent in both groups. CONCLUSIONS: Trivalent @entity2 can be safely administered to @entity0 receiving chemotherapy with improved immunogenicity and seroconversion compared to standard-dose vaccine. Post-vaccination seroprotection rates were similar in both groups. A larger study is needed to show clinical benefits with @entity3 in this population. This study was registered at ClinicalTrials.gov as NCT01666782.

title: Improved immunogenicity of XXXX compared to standard-dose influenza vaccine in adult oncology @entity0 younger than 65 years receiving chemotherapy: A pilot randomized clinical trial.

answer: @entity2


abstract: PURPOSE: @entity0 undergoing chemotherapy often fail to develop robust responses to influenza vaccination. Compared to standard-dose influenza vaccine ( @entity1 ), @entity2 ( @entity3 ) has shown improved immunogenicity and protection against @entity2 in adults 65 years and older. This study compared the immunogenicity and tolerability of @entity3 to @entity1 in adults younger than 65 years of age receiving chemotherapy. METHODS: This double-blind study randomized @entity0 receiving chemotherapy to vaccination with either @entity1 or @entity3 influenza vaccine. Hemagglutination inhibition assays (HAI) were performed prior to and 4 weeks after vaccination. HAI were summarized as geometric mean titers (GMT), seroconversion rates, and seroprotection rates. RESULTS: A total of 105 subjects were enrolled in the trial (51 received @entity1 and 54 received @entity3 ). Subjects were well matched for demographic and medical conditions. Both vaccines were well tolerated with no SAEs. Of the 100 subjects with evaluable data, seroconversion rates for all 3 influenza antigens _ post-vaccination GMTs for H3N2 _ B strains were significantly improved with @entity3 compared to @entity1 . Seroprotection was excellent and equivalent in both groups. CONCLUSIONS: Trivalent @entity2 can be safely administered to @entity0 receiving chemotherapy with improved immunogenicity and seroconversion compared to standard-dose vaccine. Post-vaccination seroprotection rates were similar in both groups. A larger study is needed to show clinical benefits with @entity3 in this population. This study was registered at ClinicalTrials.gov as NCT01666782.

title: Improved immunogenicity of @entity2 compared to standard-dose influenza vaccine in adult oncology XXXX younger than 65 years receiving chemotherapy: A pilot randomized clinical trial.

answer: @entity0


abstract: UNASSIGNED: In Italy, each year 500000 couples refer to specialized centers due to reproductive problems. Among them, recurrent @entity6 (RPL) represents a problem of great importance, given that it affects up to 5% of @entity0 of childbearing age. Infertility, on the other hand, is a condition that currently covers 10-20% of couples of reproductive age, being idiopathic in 20% of cases. Accumulating evidence support the concept that changes of @entity10 , generically defined as the presence of a thrombophilic state (congenital or acquired), are the basis of 40-70% of cases of multiple abortions or @entity5 . Several evidences support the hypothesis that @entity7 , a hallmark of a condition of low-grade @entity2 , is one of the earliest manifestations of @entity9 phenomena. To date, it's believed that, while the antiinflammatory Th2 cytokines (i.e. @entity8 ) can exert a protective role in pregnancy, the pro-inflammatory @entity12 ones (i.e. interferon-y, @entity1 @entity3 factor-a,) have deleterious effects on pregnancy outcome, including fertilization and implantation failure. Moreover, development of many pregnancy complications, first and foremost @entity13 ( @entity13 ), recognizes similar mechanism(s). As @entity13 is the main preventable cause of mortality during pregnancy, thromboprophylaxis is mandatory according to individual @entity13 risk, influenced by the presence of thrombophilic conditions. In this review, we will analyze the relationship between @entity4 and pregnancy complications, with particular focus on the role of @entity2 . Subsequently, we will consider some issues related to the @entity11 risk in pregnancy. Finally, the role of thromboprophylaxis in pregnancy will be discussed.

title: @entity2 and XXXX in Pregnancy Complications: Implications for Risk Assessment and Clinical Management.

answer: @entity4


abstract: UNASSIGNED: In Italy, each year 500000 couples refer to specialized centers due to reproductive problems. Among them, recurrent @entity6 (RPL) represents a problem of great importance, given that it affects up to 5% of @entity0 of childbearing age. Infertility, on the other hand, is a condition that currently covers 10-20% of couples of reproductive age, being idiopathic in 20% of cases. Accumulating evidence support the concept that changes of @entity10 , generically defined as the presence of a thrombophilic state (congenital or acquired), are the basis of 40-70% of cases of multiple abortions or @entity5 . Several evidences support the hypothesis that @entity7 , a hallmark of a condition of low-grade @entity2 , is one of the earliest manifestations of @entity9 phenomena. To date, it's believed that, while the antiinflammatory Th2 cytokines (i.e. @entity8 ) can exert a protective role in pregnancy, the pro-inflammatory @entity12 ones (i.e. interferon-y, @entity1 @entity3 factor-a,) have deleterious effects on pregnancy outcome, including fertilization and implantation failure. Moreover, development of many pregnancy complications, first and foremost @entity13 ( @entity13 ), recognizes similar mechanism(s). As @entity13 is the main preventable cause of mortality during pregnancy, thromboprophylaxis is mandatory according to individual @entity13 risk, influenced by the presence of thrombophilic conditions. In this review, we will analyze the relationship between @entity4 and pregnancy complications, with particular focus on the role of @entity2 . Subsequently, we will consider some issues related to the @entity11 risk in pregnancy. Finally, the role of thromboprophylaxis in pregnancy will be discussed.

title: XXXX and @entity4 in Pregnancy Complications: Implications for Risk Assessment and Clinical Management.

answer: @entity2


abstract: OBJECTIVE: Preoccupation with perceived bodily odor has been described in @entity1 for more than a century; however, @entity4 (ORS) is scarce. This study investigated the phenomenology of ORS in a broadly ascertained, diverse sample. METHOD: Data were obtained from 253 subjects in an internet-based survey that operated from January - March 2010. Measures included the Yale-Brown Obsessive Compulsive Scale Modified for ORS (ORS-YBOCS), Work and Social Adjustment Scale (WSAS), @entity2 Anxiety Stress Scales (DASS), and symptom specific questionnaires developed for this study. RESULTS: Individuals reported, on average, moderately severe ORS symptoms. The average age of onset of ORS symptoms was 21.1years, with 54% reporting a chronic, unremitting course. Individuals endorsed a lifetime average of two malodorous preoccupations, most commonly stool, garbage, and @entity3 . Odors were most often reported to emanate from the armpits, feet, and breasts. Nearly all @entity0 engaged in time-consuming rituals to try to hide or fix their perceived malodor (e.g., checking and camouflaging). Eighteen percent reported poor or delusional insight and 64.0% reported ideas or delusions of reference. More severe ORS symptoms were moderately associated with female gender, poorer insight, and higher levels of impairment (in work, social leisure, ability to maintain close relationships, and consecutive days housebound). CONCLUSION: This is the largest study on ORS to date. Results underscore the clinical significance and psychosocial impact of this understudied disorder, and highlight the need for subsequent research to examine clinical features and inform treatment.

title: Clinical features of XXXX : An internet-based study.

answer: @entity4


abstract: Childhood onset @entity3 is uncommon. In addition to occurring in @entity0 with @entity5 , @entity6 , @entity3 , nevus sebaceus, radiotherapy-treated @entity1 , solid organ transplants, and @entity4 , childhood onset @entity3 has also occurred, albeit less commonly, de novo. We describe a @entity0 with @entity3 . Previously published @entity0 with de novo @entity3 were collected from computerized medical literature search (PubMed) and citations from earlier reports. To our knowledge, childhood onset @entity3 has been observed in a total of 107 @entity0 , including our @entity0 . @entity1 were most commonly located on the head (90%). The @entity1 are most frequently nodular in appearance (52%) and in histology (at least 17%); however, @entity2 histologic variants were observed in 20% of @entity1 . @entity3 in @entity0 may be associated with prior sun exposure. The most common treatment is excision, with or without using the Mohs technique. However, 15 of 85 @entity0 , nearly 20%, developed recurrent @entity1 during a follow-up period ranging from 4 months to 20 years.

title: XXXX in childhood: case report and literature review.

answer: @entity3


abstract: Classification is not a trivial matter. In Burmese Days, George Orwell writes, "It is devilish to suffer from a @entity1 that is all but nameless. Blessed are they who are stricken only with classifiable diseases! Blessed are the poor, the sick, the crossed in love, for at least other @entity0 know what is the matter with them and will listen to their belly-achings with sympathy." @entity0 who have @entity3 are particularly susceptible to this Orwellian lamentation. They are afflicted by symptoms that defy simple explanations. As detailed in this article, there is a spectrum of medical and psychiatric factors that can cause or contribute to somatic symptom burden. Research is continuing to reveal the central mechanisms that may provide a common pathway for physical and psychologic symptoms. The dualism that places some somatic symptom disorders on @entity2 and others on @entity2 III gradually may fade in the coming decades as what the unifying causes are among common symptoms and the multicausal nature of many symptoms are discovered. Meanwhile, the classification systems should continue to operate on pragmatic principles where mechanistic explanations are lacking. This will allow grouping @entity0 into categories that inform research, scientific and @entity0 communication, prognostication, and clinical management. Coupling a heuristic classification system with evidence-based measures for assessing severity and monitoring treatment outcomes are important steps in the optimal care of symptomatic @entity0 .

title: XXXX and recent diagnostic controversies.

answer: @entity3


abstract: BACKGROUND: It has been suggested in the literature that raised heart rate in the early period after @entity1 is associated with the development of post-traumatic psychopathology, but little account has been taken of the potential confounding effect of injury severity. MATERIALS AND METHODS: A cohort of 154 @entity0 , studied as part of a wider investigation of @entity1 outcomes, was included. Initial heart rate in the accident _ emergency department, and injury severity score and new injury severity scores were recorded. @entity0 completed the General Health Questionnaire (GHQ-28) as a measure of psychopathology at presentation and again at two- and six-month follow-up. RESULTS: There was no relationship between psychopathology at presentation and initial heart rate or injury severity. Raised heart rate was associated with post-traumatic psychopathology at two months but not at six months. When the potential confounding effect of injury severity was controlled for, there was no independent correlation between heart rate and post-traumatic psychopathology. Injury severity score and new injury severity scores were strongly associated with GHQ-28 caseness. CONCLUSION: Post-traumatic @entity2 is not associated with development of psychopathology, but injury severity is. Previous studies that have suggested a link between @entity2 and development of psychopathology are flawed because they have not considered the confounding effect of severity of injury.

title: If a XXXX @entity0 is tachycardic, should we call for a counsellor?

answer: @entity1


abstract: BACKGROUND: It has been suggested in the literature that raised heart rate in the early period after @entity1 is associated with the development of post-traumatic psychopathology, but little account has been taken of the potential confounding effect of injury severity. MATERIALS AND METHODS: A cohort of 154 @entity0 , studied as part of a wider investigation of @entity1 outcomes, was included. Initial heart rate in the accident _ emergency department, and injury severity score and new injury severity scores were recorded. @entity0 completed the General Health Questionnaire (GHQ-28) as a measure of psychopathology at presentation and again at two- and six-month follow-up. RESULTS: There was no relationship between psychopathology at presentation and initial heart rate or injury severity. Raised heart rate was associated with post-traumatic psychopathology at two months but not at six months. When the potential confounding effect of injury severity was controlled for, there was no independent correlation between heart rate and post-traumatic psychopathology. Injury severity score and new injury severity scores were strongly associated with GHQ-28 caseness. CONCLUSION: Post-traumatic @entity2 is not associated with development of psychopathology, but injury severity is. Previous studies that have suggested a link between @entity2 and development of psychopathology are flawed because they have not considered the confounding effect of severity of injury.

title: If a @entity1 XXXX is tachycardic, should we call for a counsellor?

answer: @entity0


abstract: UNASSIGNED: @entity11 is increasingly recognized in @entity0 with otherwise unexplained @entity2 with @entity5 . Among these, patients with anti- @entity7 receptor (NMDAR) @entity4 present @entity5 , @entity6 , and @entity3 symptoms. However, the functional consequences of such autoantibodies are poorly understood. In order to investigate the pathophysiology of this disease, we stereotactically injected either cerebrospinal fluid (CSF) from three anti-NMDAR @entity4 @entity0 or commercially available anti- @entity9 into the dentate gyrus of adult female @entity1 . Control animals were injected with either CSF obtained from three @entity5 @entity0 ( @entity10 , @entity5 , focal @entity8 ) lacking anti-NMDAR or saline. Intracellular recordings from dentate gyrus granule cells showed a significant reduction of the NMDAR-evoked excitatory postsynaptic potentials (NMDAR-EPSPs) in animals treated with anti-NMDAR. As a consequence of this, action potential firing in these cells by NMDAR-EPSPs was significantly impaired. Long-term potentiation in the dentate gyrus was also significantly reduced in @entity1 injected with anti-NMDAR as compared to control animals. This was accompanied by a significantly impaired learning performance in the Morris water maze hidden platform task when the animals had been injected with anti-NMDAR antibody-containing CSF. Our findings suggest that anti-NMDAR lead to reduced NMDAR function in vivo which could contribute to the @entity6 found in patients with anti-NMDAR @entity4 .

title: Stereotactic injection of cerebrospinal fluid from anti- XXXX receptor @entity4 into @entity1 dentate gyrus impairs @entity7 receptor function.

answer: @entity7


abstract: UNASSIGNED: @entity11 is increasingly recognized in @entity0 with otherwise unexplained @entity2 with @entity5 . Among these, patients with anti- @entity7 receptor (NMDAR) @entity4 present @entity5 , @entity6 , and @entity3 symptoms. However, the functional consequences of such autoantibodies are poorly understood. In order to investigate the pathophysiology of this disease, we stereotactically injected either cerebrospinal fluid (CSF) from three anti-NMDAR @entity4 @entity0 or commercially available anti- @entity9 into the dentate gyrus of adult female @entity1 . Control animals were injected with either CSF obtained from three @entity5 @entity0 ( @entity10 , @entity5 , focal @entity8 ) lacking anti-NMDAR or saline. Intracellular recordings from dentate gyrus granule cells showed a significant reduction of the NMDAR-evoked excitatory postsynaptic potentials (NMDAR-EPSPs) in animals treated with anti-NMDAR. As a consequence of this, action potential firing in these cells by NMDAR-EPSPs was significantly impaired. Long-term potentiation in the dentate gyrus was also significantly reduced in @entity1 injected with anti-NMDAR as compared to control animals. This was accompanied by a significantly impaired learning performance in the Morris water maze hidden platform task when the animals had been injected with anti-NMDAR antibody-containing CSF. Our findings suggest that anti-NMDAR lead to reduced NMDAR function in vivo which could contribute to the @entity6 found in patients with anti-NMDAR @entity4 .

title: Stereotactic injection of cerebrospinal fluid from anti- @entity7 receptor @entity4 into @entity1 dentate gyrus impairs XXXX receptor function.

answer: @entity7


abstract: UNASSIGNED: @entity11 is increasingly recognized in @entity0 with otherwise unexplained @entity2 with @entity5 . Among these, patients with anti- @entity7 receptor (NMDAR) @entity4 present @entity5 , @entity6 , and @entity3 symptoms. However, the functional consequences of such autoantibodies are poorly understood. In order to investigate the pathophysiology of this disease, we stereotactically injected either cerebrospinal fluid (CSF) from three anti-NMDAR @entity4 @entity0 or commercially available anti- @entity9 into the dentate gyrus of adult female @entity1 . Control animals were injected with either CSF obtained from three @entity5 @entity0 ( @entity10 , @entity5 , focal @entity8 ) lacking anti-NMDAR or saline. Intracellular recordings from dentate gyrus granule cells showed a significant reduction of the NMDAR-evoked excitatory postsynaptic potentials (NMDAR-EPSPs) in animals treated with anti-NMDAR. As a consequence of this, action potential firing in these cells by NMDAR-EPSPs was significantly impaired. Long-term potentiation in the dentate gyrus was also significantly reduced in @entity1 injected with anti-NMDAR as compared to control animals. This was accompanied by a significantly impaired learning performance in the Morris water maze hidden platform task when the animals had been injected with anti-NMDAR antibody-containing CSF. Our findings suggest that anti-NMDAR lead to reduced NMDAR function in vivo which could contribute to the @entity6 found in patients with anti-NMDAR @entity4 .

title: Stereotactic injection of cerebrospinal fluid from anti- @entity7 receptor XXXX into @entity1 dentate gyrus impairs @entity7 receptor function.

answer: @entity4


abstract: UNASSIGNED: @entity11 is increasingly recognized in @entity0 with otherwise unexplained @entity2 with @entity5 . Among these, patients with anti- @entity7 receptor (NMDAR) @entity4 present @entity5 , @entity6 , and @entity3 symptoms. However, the functional consequences of such autoantibodies are poorly understood. In order to investigate the pathophysiology of this disease, we stereotactically injected either cerebrospinal fluid (CSF) from three anti-NMDAR @entity4 @entity0 or commercially available anti- @entity9 into the dentate gyrus of adult female @entity1 . Control animals were injected with either CSF obtained from three @entity5 @entity0 ( @entity10 , @entity5 , focal @entity8 ) lacking anti-NMDAR or saline. Intracellular recordings from dentate gyrus granule cells showed a significant reduction of the NMDAR-evoked excitatory postsynaptic potentials (NMDAR-EPSPs) in animals treated with anti-NMDAR. As a consequence of this, action potential firing in these cells by NMDAR-EPSPs was significantly impaired. Long-term potentiation in the dentate gyrus was also significantly reduced in @entity1 injected with anti-NMDAR as compared to control animals. This was accompanied by a significantly impaired learning performance in the Morris water maze hidden platform task when the animals had been injected with anti-NMDAR antibody-containing CSF. Our findings suggest that anti-NMDAR lead to reduced NMDAR function in vivo which could contribute to the @entity6 found in patients with anti-NMDAR @entity4 .

title: Stereotactic injection of cerebrospinal fluid from anti- @entity7 receptor @entity4 into XXXX dentate gyrus impairs @entity7 receptor function.

answer: @entity1


abstract: BACKGROUND: Recently, there has been tremendous interest in the sinus microbiome and how it relates to disease. However, a lack of a standardized sample collection and DNA extraction methods makes comparison of results across studies nearly impossible. Furthermore, current techniques fail to identify which components of the microbiome are actually alive within the host at the time of sampling. OBJECTIVE: To develop and optimize a method to differentiate which bacterial species in the @entity0 sinus microbiome are live versus dead. METHODS: Duplicate samples from the middle meatus of @entity0 with healthy sinus tissue and those @entity0 with chronic rhinosinusitis were collected by using brushes (n = 12), swabs (n = 27), and tissue biopsy (n = 8) methods. One sample from each pair was either @entity1 - or control-treated before DNA extraction. The relative bacterial versus @entity0 composition of each sample was determined. @entity2 ribosomal RNA gene analysis was performed on a six-paired sample from @entity0 with healthy sinus tissue. RESULTS: We found that swabs and brushes collected a higher percentage of bacterial DNA than did tissue biopsy. We also determined that as much as 50% of the bacteria collected in these samples was already dead at the time of collection. The 16S ribosomal RNA gene analysis found significant changes in the relative abundance of taxa identified in the live versus dead bacterial communities of healthy @entity0 sinuses. CONCLUSIONS: Our findings indicated that swabs provided the best quality microbiome samples and that a large portion of the bacteria identified in the sinus were @entity1 sensitive. These results highlighted the need for improved techniques such as those presented here, which can differentiate between living and dead bacteria in a sample, a potentially critical distinction when examining changes in sinus innate immune function because both components play important, but distinct, functions. Further studies will determine how these living and dead bacterial populations shift in different disease states and after clinical intervention.

title: Dead or alive: XXXX sensitive bacteria and implications for the sinus microbiome.

answer: @entity1


abstract: BACKGROUND: The strategy for treating @entity0 with severe asymptomatic @entity7 and @entity5 remains unresolved. Staged or combined carotid endarterectomy in these @entity0 offers the potential benefit of decreased @entity2 during and after cardiac surgery; however, in high-risk @entity0 with severe @entity6 , @entity9 , or @entity1 , the incidence of @entity4 and @entity3 is significantly higher. METHODS AND RESULTS: We report the results of a prospective, single-center study designed to evaluate the feasibility and safety of @entity10 ( @entity10 ) before cardiac surgery in neurologically asymptomatic @entity0 . The periprocedural and long-term outcomes of 356 consecutive @entity0 who underwent @entity10 before cardiac surgery were analyzed. The procedural success rate of @entity10 was 97.7%. The @entity4 and @entity3 rate from time of @entity10 to 30 days after cardiac surgery was 4.8% (n=17). The @entity8 rate from time of @entity10 to 30 days after cardiac surgery was 2.0% (n=7), and the combined @entity4 , @entity3 , and @entity8 rate was 6.7% (n=24). Distal embolic protection devices were used in 40% of the cases. CONCLUSIONS: This large cohort of asymptomatic @entity0 who underwent staged @entity10 and cardiac surgery experienced a low periprocedural complication rate. The high rate of freedom from @entity4 and @entity3 during the 5 years of follow-up supports the long-term durability of this approach. Our findings suggest that this new strategy may become a valuable alternative in the treatment of @entity0 with combined carotid and @entity5 .

title: Staged carotid angioplasty and stenting followed by cardiac surgery in @entity0 with severe asymptomatic XXXX : early and long-term results.

answer: @entity7


abstract: BACKGROUND: The strategy for treating @entity0 with severe asymptomatic @entity7 and @entity5 remains unresolved. Staged or combined carotid endarterectomy in these @entity0 offers the potential benefit of decreased @entity2 during and after cardiac surgery; however, in high-risk @entity0 with severe @entity6 , @entity9 , or @entity1 , the incidence of @entity4 and @entity3 is significantly higher. METHODS AND RESULTS: We report the results of a prospective, single-center study designed to evaluate the feasibility and safety of @entity10 ( @entity10 ) before cardiac surgery in neurologically asymptomatic @entity0 . The periprocedural and long-term outcomes of 356 consecutive @entity0 who underwent @entity10 before cardiac surgery were analyzed. The procedural success rate of @entity10 was 97.7%. The @entity4 and @entity3 rate from time of @entity10 to 30 days after cardiac surgery was 4.8% (n=17). The @entity8 rate from time of @entity10 to 30 days after cardiac surgery was 2.0% (n=7), and the combined @entity4 , @entity3 , and @entity8 rate was 6.7% (n=24). Distal embolic protection devices were used in 40% of the cases. CONCLUSIONS: This large cohort of asymptomatic @entity0 who underwent staged @entity10 and cardiac surgery experienced a low periprocedural complication rate. The high rate of freedom from @entity4 and @entity3 during the 5 years of follow-up supports the long-term durability of this approach. Our findings suggest that this new strategy may become a valuable alternative in the treatment of @entity0 with combined carotid and @entity5 .

title: Staged carotid angioplasty and stenting followed by cardiac surgery in XXXX with severe asymptomatic @entity7 : early and long-term results.

answer: @entity0


abstract: UNASSIGNED: Invasive @entity3 (IDC and ILC) are the two most common histological types of @entity0 , and have been considered to develop from terminal duct lobular unit but their molecular, pathological, and clinical features are markedly different between them. These differences could be due to different mechanisms of carcinogenesis and @entity1 microenvironment, especially @entity1 -associated fibroblasts (CAFs) but little has been explored in this aspect. Therefore, in this study, we evaluated the status of angiogenesis, maturation of intratumoral microvessels, and proliferation of CAFs using immunohistochemistry and PCR array analysis to explore the differences of @entity1 microenvironment between ILC and IDC. We studied grade- and age-matched, luminal-like ILC and IDC. We immunolocalized @entity5 and aSMA for an evaluation of CAFs and @entity4 , @entity6 , a specific marker of proliferative endothelial cells and nestin, a marker of pericytes for studying the status of proliferation and maturation of intratumoral microvessel. We also performed PCR array analysis to evaluate angiogenic factors in @entity1 stromal components. The number of CAFs, microvessel density, and @entity6 / @entity4 positive ratio were all significantly higher in ILC than IDC but nestin immunoreactivity in intratumoral microvessel was significantly lower in ILC. These results did indicate that proliferation of CAFs and endothelial cells was more pronounced in ILC than IDC but newly formed microvessels were less mature than those in IDC. PCR array analysis also revealed that @entity2 expression was higher in ILC than IDC. This is the first study to demonstrate the differences of @entity1 microenvironment including CAFs and proliferation and maturation of intratumoral vessels between ILC and IDC.

title: Tumor microenvironment in XXXX : possible therapeutic targets.

answer: @entity3


abstract: OBJECTIVE: To explore the regional brain activities in @entity0 with chronic @entity1 (PCPIs) and their sex differences. METHODS: Forty-two PCPIs (27 females, 15 males) and 42 @entity2 ( @entity2 ; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. @entity3 ( @entity3 ) method was used to assess the local brain features. The mean signal values of the different @entity3 areas were analyzed with a receiver operating characteristic (ROC) curve. Simple linear regression analysis was performed to investigate the relationships between clinical features and different brain areas. RESULTS: Both female and male PCPIs showed higher @entity3 in the temporal lobe and occipital lobe, especially in female PCPIs. Female PCPIs had lower @entity3 in the bilateral cerebellum posterior lobe, left dorsolateral prefrontal cortex, and bilateral limbic lobe; however, male PCPIs showed lower @entity3 in the left occipital gyrus. The mean signal value of the cerebellum in female PCPIs showed negative correlations with negative emotions. Compared with male PCPIs, female PCPIs showed higher @entity3 in the bilateral middle temporal gyrus and lower @entity3 in the left limbic lobe. The different areas showed high test-retest stability (Clusters of contiguous volumes >= 1080 mm3 with an intraclass correlation coefficient >= 0.80) and high degree of sensitivity and specificity. CONCLUSIONS: Female PCPIs showed more regional brain differences with higher and lower @entity3 responses than male PCPIs. However, they shared analogous excessive hyperarousal mechanism and wide variations in aberrant brain areas.

title: Gender Differences in Regional Brain Activity in @entity0 with XXXX : Evidence from a Resting-State fMRI Study.

answer: @entity1


abstract: OBJECTIVE: To explore the regional brain activities in @entity0 with chronic @entity1 (PCPIs) and their sex differences. METHODS: Forty-two PCPIs (27 females, 15 males) and 42 @entity2 ( @entity2 ; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. @entity3 ( @entity3 ) method was used to assess the local brain features. The mean signal values of the different @entity3 areas were analyzed with a receiver operating characteristic (ROC) curve. Simple linear regression analysis was performed to investigate the relationships between clinical features and different brain areas. RESULTS: Both female and male PCPIs showed higher @entity3 in the temporal lobe and occipital lobe, especially in female PCPIs. Female PCPIs had lower @entity3 in the bilateral cerebellum posterior lobe, left dorsolateral prefrontal cortex, and bilateral limbic lobe; however, male PCPIs showed lower @entity3 in the left occipital gyrus. The mean signal value of the cerebellum in female PCPIs showed negative correlations with negative emotions. Compared with male PCPIs, female PCPIs showed higher @entity3 in the bilateral middle temporal gyrus and lower @entity3 in the left limbic lobe. The different areas showed high test-retest stability (Clusters of contiguous volumes >= 1080 mm3 with an intraclass correlation coefficient >= 0.80) and high degree of sensitivity and specificity. CONCLUSIONS: Female PCPIs showed more regional brain differences with higher and lower @entity3 responses than male PCPIs. However, they shared analogous excessive hyperarousal mechanism and wide variations in aberrant brain areas.

title: Gender Differences in Regional Brain Activity in XXXX with @entity1 : Evidence from a Resting-State fMRI Study.

answer: @entity0


abstract: BACKGROUND: @entity1 misuse imposes substantial harm on Indigenous Australians whose health status is poorer than non-Indigenous Australians. Although Indigenous youth are over represented in Indigenous @entity1 harms, few interventions addressing @entity1 -related harm among Indigenous youth have been evaluated. Given this paucity of evidence, a survey was designed to evaluate the effects of a whole-of-community, anti-binge drinking intervention for young @entity0 in an Indigenous community in far north Queensland, Australia. METHODS: A cross sectional, baseline-post intervention study assessed the impact of a two year anti-binge drinking intervention targeting young @entity0 (18-24 years). A survey was developed and implemented at baseline and again two-years post-intervention, administered by young local @entity0 employed as research assistants. Survey respondents were recruited through snowballing techniques. Survey items asked about respondents' knowledge of binge drinking and standard drinks, involvement in @entity1 -free social activities, frequency of short-term risky drinking (binge drinking), and mean @entity1 expenditure during short-term risky drinking occasions. The intervention was called Beat da Binge. Two major events and multiple minor activities each year were implemented, focusing on drinking education, @entity1 -free community-wide social events, and youth-specific sporting and social activities to facilitate self-empowerment. RESULTS: Beat da Binge was associated with a statistically significant 10 % reduction in the proportion of survey respondents who reported that they had engaged in an episode of short-term risky drinking, in the frequency of short-term risky drinking for all beverage types except wine (ranging from 4 % to 31 % reductions), in mean expenditure on @entity1 during short-term risky drinking sessions ( 6.25) and in the proportion of activities with family/friends that usually include @entity1 (7 %). There were also statistically significant increases in awareness of binge drinking and standard drinks (28 % and 21 % respectively). In addition to @entity1 -specific outcomes, there was a statistically significant 8 % increase in the proportions of respondents engaged in training as their main weekday activity, which was partly off-set by a 13 % reduction in those whose main weekday activity was family care or home-related tasks. CONCLUSIONS: Reductions in the proportion of survey respondents who reported binge drinking, along with increases in awareness and involvement in @entity1 -free social activities suggest the community-based intervention was effective. The potential impact of sample selection and self-reporting limitations on results need further investigation. There is an urgent need for Indigenous, community-driven public health programs that are well evaluated to both improve Indigenous health and the strength of the current evidence base to inform future community interventions.

title: The impact of a community-based risky drinking intervention (Beat da Binge) on Indigenous young XXXX .

answer: @entity0


abstract: BACKGROUND: The beneficial effects of @entity8 in the treatment of severe @entity4 , @entity5 , and @entity4 -associated disseminated @entity7 (DIC) have recently been reported. However, the mechanisms underlying the therapeutic benefits of @entity8 in these conditions have not yet been clearly elucidated. The purpose of this study was to confirm the effect of @entity8 of neutralizing histone @entity3 . METHODS: @entity2 models of histone H3-induced @entity6 were administered in a low or high dose of unfractionated @entity8 (UFH), low-molecular-weight @entity8 (LMWH), or @entity9 , and the therapeutic effects of each anticoagulant were examined. In another series, the survival of the histone H3-administered animals was evaluated. Furthermore, the effect of each of the aforementioned anticoagulants on cell death induced by histone H3 was examined in cultured vascular endothelial cells and leukocytes. RESULTS: Although UFH, LMWH, and @entity9 significantly suppressed the histone-induced decrease of the WBC and platelet counts in the animal models of @entity6 , only UFH and LMWH attenuated @entity1 . In addition, the mortality was significantly reduced only by high-dose UFH and LMWH. The in vitro study revealed that both vascular endothelial cell death and leukocyte cell death were significantly attenuated by UFH and LMWH but not by @entity9 . CONCLUSIONS: The histone-neutralizing effect of @entity8 may contribute to the beneficial effects of heparins observed in the animal study. The results of the in vitro study further confirmed the above contention and suggested that @entity8 binds to histones to attenuate the cytotoxic actions of the latter. Since @entity8 has been demonstrated to protect animals from the organ damage induced by histones and consequently reduce the mortality, administration of @entity8 could become a treatment of choice for @entity0 suffering from severe @entity4 .

title: Heparins attenuated histone-mediated XXXX in vitro and improved the survival in a @entity2 model of histone-induced @entity6 .

answer: @entity3


abstract: BACKGROUND: The beneficial effects of @entity8 in the treatment of severe @entity4 , @entity5 , and @entity4 -associated disseminated @entity7 (DIC) have recently been reported. However, the mechanisms underlying the therapeutic benefits of @entity8 in these conditions have not yet been clearly elucidated. The purpose of this study was to confirm the effect of @entity8 of neutralizing histone @entity3 . METHODS: @entity2 models of histone H3-induced @entity6 were administered in a low or high dose of unfractionated @entity8 (UFH), low-molecular-weight @entity8 (LMWH), or @entity9 , and the therapeutic effects of each anticoagulant were examined. In another series, the survival of the histone H3-administered animals was evaluated. Furthermore, the effect of each of the aforementioned anticoagulants on cell death induced by histone H3 was examined in cultured vascular endothelial cells and leukocytes. RESULTS: Although UFH, LMWH, and @entity9 significantly suppressed the histone-induced decrease of the WBC and platelet counts in the animal models of @entity6 , only UFH and LMWH attenuated @entity1 . In addition, the mortality was significantly reduced only by high-dose UFH and LMWH. The in vitro study revealed that both vascular endothelial cell death and leukocyte cell death were significantly attenuated by UFH and LMWH but not by @entity9 . CONCLUSIONS: The histone-neutralizing effect of @entity8 may contribute to the beneficial effects of heparins observed in the animal study. The results of the in vitro study further confirmed the above contention and suggested that @entity8 binds to histones to attenuate the cytotoxic actions of the latter. Since @entity8 has been demonstrated to protect animals from the organ damage induced by histones and consequently reduce the mortality, administration of @entity8 could become a treatment of choice for @entity0 suffering from severe @entity4 .

title: Heparins attenuated histone-mediated @entity3 in vitro and improved the survival in a @entity2 model of histone-induced XXXX .

answer: @entity6


abstract: BACKGROUND: The beneficial effects of @entity8 in the treatment of severe @entity4 , @entity5 , and @entity4 -associated disseminated @entity7 (DIC) have recently been reported. However, the mechanisms underlying the therapeutic benefits of @entity8 in these conditions have not yet been clearly elucidated. The purpose of this study was to confirm the effect of @entity8 of neutralizing histone @entity3 . METHODS: @entity2 models of histone H3-induced @entity6 were administered in a low or high dose of unfractionated @entity8 (UFH), low-molecular-weight @entity8 (LMWH), or @entity9 , and the therapeutic effects of each anticoagulant were examined. In another series, the survival of the histone H3-administered animals was evaluated. Furthermore, the effect of each of the aforementioned anticoagulants on cell death induced by histone H3 was examined in cultured vascular endothelial cells and leukocytes. RESULTS: Although UFH, LMWH, and @entity9 significantly suppressed the histone-induced decrease of the WBC and platelet counts in the animal models of @entity6 , only UFH and LMWH attenuated @entity1 . In addition, the mortality was significantly reduced only by high-dose UFH and LMWH. The in vitro study revealed that both vascular endothelial cell death and leukocyte cell death were significantly attenuated by UFH and LMWH but not by @entity9 . CONCLUSIONS: The histone-neutralizing effect of @entity8 may contribute to the beneficial effects of heparins observed in the animal study. The results of the in vitro study further confirmed the above contention and suggested that @entity8 binds to histones to attenuate the cytotoxic actions of the latter. Since @entity8 has been demonstrated to protect animals from the organ damage induced by histones and consequently reduce the mortality, administration of @entity8 could become a treatment of choice for @entity0 suffering from severe @entity4 .

title: Heparins attenuated histone-mediated @entity3 in vitro and improved the survival in a XXXX model of histone-induced @entity6 .

answer: @entity2


abstract: UNASSIGNED: @entity5 pyrophosphorylase (GMPase) catalyzes the synthesis of @entity5 , which is a precursor for @entity1 ( @entity3 ) synthesis in plants. The @entity0 genome encodes three GMPase homologs OsVTC1-1, OsVTC1-3 and OsVTC1-8, but their roles in @entity3 synthesis are unclear. The overexpression of OsVTC1-1 or OsVTC1-3 restored the @entity3 synthesis of @entity4 -1 in @entity2 , while that of OsVTC1-8 did not, indicating that only OsVTC1-1 and OsVTC1-3 are involved in @entity3 synthesis in @entity0 . Similar to @entity2 @entity4 , the expression of OsVTC1-1 was high in leaves, induced by light, and inhibited by dark. Unlike OsVTC1-1, the expression level of OsVTC1-3 was high in roots and quickly induced by the dark, while the transcription level of OsVTC1-8 did not show obvious changes under constant light or dark treatments. In OsVTC1-1 RNAi plants, the @entity3 content of @entity0 leaves decreased, and the @entity3 production induced by light was limited. In contrast, OsVTC1-3 RNAi lines altered @entity3 synthesis levels in @entity0 roots, but not in the leaves or under the light/dark treatment. The enzyme activity showed that OsVTC1-1 and OsVTC1-3 had higher GMPase activities than OsVTC1-8 in vitro. Our data showed that, unlike in @entity2 , the @entity0 GPMase homologous proteins illustrated a new model in @entity3 synthesis: OsVTC1-1 may be involved in the @entity3 synthesis, which takes place in leaves, while OsVTC1-3 may be responsible for @entity3 synthesis in roots. The different roles of @entity0 GMPase homologous proteins in @entity3 synthesis may be due to their differences in transcript levels and enzyme activities.

title: @entity0 GDP-mannose pyrophosphorylase OsVTC1-1 and OsVTC1-3 play different roles in XXXX synthesis.

answer: @entity1


abstract: UNASSIGNED: @entity5 pyrophosphorylase (GMPase) catalyzes the synthesis of @entity5 , which is a precursor for @entity1 ( @entity3 ) synthesis in plants. The @entity0 genome encodes three GMPase homologs OsVTC1-1, OsVTC1-3 and OsVTC1-8, but their roles in @entity3 synthesis are unclear. The overexpression of OsVTC1-1 or OsVTC1-3 restored the @entity3 synthesis of @entity4 -1 in @entity2 , while that of OsVTC1-8 did not, indicating that only OsVTC1-1 and OsVTC1-3 are involved in @entity3 synthesis in @entity0 . Similar to @entity2 @entity4 , the expression of OsVTC1-1 was high in leaves, induced by light, and inhibited by dark. Unlike OsVTC1-1, the expression level of OsVTC1-3 was high in roots and quickly induced by the dark, while the transcription level of OsVTC1-8 did not show obvious changes under constant light or dark treatments. In OsVTC1-1 RNAi plants, the @entity3 content of @entity0 leaves decreased, and the @entity3 production induced by light was limited. In contrast, OsVTC1-3 RNAi lines altered @entity3 synthesis levels in @entity0 roots, but not in the leaves or under the light/dark treatment. The enzyme activity showed that OsVTC1-1 and OsVTC1-3 had higher GMPase activities than OsVTC1-8 in vitro. Our data showed that, unlike in @entity2 , the @entity0 GPMase homologous proteins illustrated a new model in @entity3 synthesis: OsVTC1-1 may be involved in the @entity3 synthesis, which takes place in leaves, while OsVTC1-3 may be responsible for @entity3 synthesis in roots. The different roles of @entity0 GMPase homologous proteins in @entity3 synthesis may be due to their differences in transcript levels and enzyme activities.

title: XXXX GDP-mannose pyrophosphorylase OsVTC1-1 and OsVTC1-3 play different roles in @entity1 synthesis.

answer: @entity0


abstract: BACKGROUND: The risk of @entity1 associated with aortic arch @entity2 is proportional to plaque thickness, the accurate measurement of which may influence future therapeutic decisions. Transesophageal echocardiography is the procedure of choice for plaque measurement. This study examines the reproducibility of such measurements within the context of the Aortic Arch Related Cerebral Hazard Trial of antithrombotic therapy. METHODS: Atheroma images were remeasured by 3 independent blinded observers of varying expertise. Intraobserver and interobserver variability were calculated using Lin's concordance correlation coefficient ( @entity3 ), the Bland-Altman method, and the kappa statistic. RESULTS: A total of 160 images were obtained from 96 @entity0 (68% male; mean age 74 +/- 9 years). Mean plaque thickness was 5.1 +/- 2.3 mm, range 1.2 to 19.3 mm. For intraobserver variability, @entity3 = 0.95, mean difference = 0.01 mm, and kappa = 0.71. For interobserver variability, @entity3 ranged from 0.80 to 0.91; mean difference was 0.13 to 0.48 mm; and kappa was 0.61 to 0.69. By all statistical methods, agreement was at least substantial, although lower at greater plaque thicknesses. For the clinically relevant 4 mm, agreement was 84% to 88%. CONCLUSIONS: Transesophageal echocardiography measurement of aortic plaque is substantially reproducible across a range of observer experience and, thus, is a widely applicable, adequately reliable tool for clinical and research purposes.

title: Intraobserver and interobserver variability of transesophageal echocardiography in aortic arch XXXX measurement.

answer: @entity2


abstract: BACKGROUND: To describe long term outcomes of @entity5 complex (MAC) immune reconstitution @entity1 (IRIS). METHODS: Cases of MAC IRIS were retrospectively identified at four @entity3 clinics (Michigan, Maryland, Rhode Island, and Indiana) from 1996-2004. @entity0 were included if they were initially diagnosed with @entity4 and found to have evidence of focal MAC infection documented by tissue culture or PCR after initiating HAART, and at least 6 months of follow up. RESULTS: Among the 20 @entity0 included, the mean age was 40 years, mean @entity2 cell count was 24/mm3 at pretreatment baseline and 100/mm3 at time of MAC IRIS diagnosis. Sites of disease included lymph nodes (15 @entity0 [8 peripheral, 8 abdominal and 1 peripheral and abdominal]), gastrointestinal tract (7) and liver (3). Sixteen @entity0 (80%) responded to treatment and were disease free after a mean of 17.4 months of therapy for MAC IRIS; IRIS therapy was withdrawn in 6 without relapse. Four @entity0 (non-responder group) had persistent or relapsing disease despite 27 months of ongoing MAC IRIS treatment. At the time of resolution or last follow-up, the mean @entity2 cell count and viral load was 143/mm3 and 7,000 c/mL for responders, and 65/mm3 and 17,000 c/mL for non-responders, respectively. Most @entity0 with peripheral adenopathy were responders (7/8; 88%); many with abdominal adenopathy (4/8; 50%) were nonresponders. CONCLUSION: The majority of @entity0 with MAC IRIS eventually responded to treatment. Our sample size was not adequate to perform statistical analysis, but there was a tendency towards adequate @entity2 response to HAART and peripheral rather than intraabdominal adenopathy among responders.

title: XXXX complex immune reconstitution @entity1 : long term outcomes.

answer: @entity5


abstract: BACKGROUND: To describe long term outcomes of @entity5 complex (MAC) immune reconstitution @entity1 (IRIS). METHODS: Cases of MAC IRIS were retrospectively identified at four @entity3 clinics (Michigan, Maryland, Rhode Island, and Indiana) from 1996-2004. @entity0 were included if they were initially diagnosed with @entity4 and found to have evidence of focal MAC infection documented by tissue culture or PCR after initiating HAART, and at least 6 months of follow up. RESULTS: Among the 20 @entity0 included, the mean age was 40 years, mean @entity2 cell count was 24/mm3 at pretreatment baseline and 100/mm3 at time of MAC IRIS diagnosis. Sites of disease included lymph nodes (15 @entity0 [8 peripheral, 8 abdominal and 1 peripheral and abdominal]), gastrointestinal tract (7) and liver (3). Sixteen @entity0 (80%) responded to treatment and were disease free after a mean of 17.4 months of therapy for MAC IRIS; IRIS therapy was withdrawn in 6 without relapse. Four @entity0 (non-responder group) had persistent or relapsing disease despite 27 months of ongoing MAC IRIS treatment. At the time of resolution or last follow-up, the mean @entity2 cell count and viral load was 143/mm3 and 7,000 c/mL for responders, and 65/mm3 and 17,000 c/mL for non-responders, respectively. Most @entity0 with peripheral adenopathy were responders (7/8; 88%); many with abdominal adenopathy (4/8; 50%) were nonresponders. CONCLUSION: The majority of @entity0 with MAC IRIS eventually responded to treatment. Our sample size was not adequate to perform statistical analysis, but there was a tendency towards adequate @entity2 response to HAART and peripheral rather than intraabdominal adenopathy among responders.

title: @entity5 complex immune reconstitution XXXX : long term outcomes.

answer: @entity1


abstract: BACKGROUND: To treat advanced @entity3 due to @entity4 , surgical ventricular restoration with mitral reconstruction was conducted and evaluated. METHODS: In 95 @entity0 (81 @entity0 , mean age: 54 years), New York Heart Association class III/IV was 44/51, and 33 @entity0 (36%) were inotropic dependent preoperatively. @entity2 (>or=2+) was noted in all @entity0 . All @entity0 underwent left ventriculoplasty (septal anterior ventricular exclusion in 38, partial left ventriculectomy in 57) and mitral reconstruction (repair 53, replacement 42). Fifty-two @entity0 (55%) had concomitant tricuspid repair. Intra-aortic balloon pumping and left ventricular assist device was used in 24 @entity0 and two @entity0 , respectively. RESULTS: Hospital mortality was 11.6% (11 of 95), with 6.6% (5 of 76) in elective and 31.6% (6 of 19) in emergency operations. The ejection fraction and cardiac index increased from 22.3+/-6.3% to 27.2+/-8.0% and from 2.3+/-0.5 ml/m2/min to 2.8+/-0.5 ml/m2/min, respectively (p<0.001). The endodiastolic volume index, endosystolic volume index and diastolic dimension decreased from 232.9+/-56.1 ml/m2 to 160.0+/-49.8 ml/m2, from 178.9+/-46.7 ml/m2 to 113.8+/-44.7 ml/m2 and from 82.0+/-9.0 mm to 68.9+/-11.6 mm, respectively (p<0.001). Late @entity1 occurred in 27 @entity0 with 22 @entity1 . The mean NYHA class was 1.7 among the survivors. One-, 3- and 5-year survival rates were 72.8%, 61.4% and 50.5%, respectively. In the 62 @entity0 who were non-inotropic dependent preoperatively, 1-, 3-, and 5-year survival rates (81.8%, 73.7% and 62.9%) were significantly better than the inotropic-dependent group (55.3%, 37.3% and 28.0%). @entity0 with mitral annuloplasty showed a significantly higher 5-year survival rate than @entity0 with mitral valve replacement (59.6% vs 43.6%) in univariate analysis. By application of the exclusion site selection method, the two different ventriculoplasty procedures did not show significant difference in survival rates. Multivariate analysis showed that preoperative inotropes and old age were significant predictors for postoperative mortality. CONCLUSION: The selected ventriculoplasty in combination with mitral annuloplasty is a useful option for @entity0 with an extremely dilated @entity5 in @entity4 . Surgery should be considered before inotropic dependency occurs when prior medical treatment has failed.

title: Selected ventriculoplasty for XXXX with advanced @entity3 : midterm results and risk analysis.

answer: @entity4


abstract: BACKGROUND: To treat advanced @entity3 due to @entity4 , surgical ventricular restoration with mitral reconstruction was conducted and evaluated. METHODS: In 95 @entity0 (81 @entity0 , mean age: 54 years), New York Heart Association class III/IV was 44/51, and 33 @entity0 (36%) were inotropic dependent preoperatively. @entity2 (>or=2+) was noted in all @entity0 . All @entity0 underwent left ventriculoplasty (septal anterior ventricular exclusion in 38, partial left ventriculectomy in 57) and mitral reconstruction (repair 53, replacement 42). Fifty-two @entity0 (55%) had concomitant tricuspid repair. Intra-aortic balloon pumping and left ventricular assist device was used in 24 @entity0 and two @entity0 , respectively. RESULTS: Hospital mortality was 11.6% (11 of 95), with 6.6% (5 of 76) in elective and 31.6% (6 of 19) in emergency operations. The ejection fraction and cardiac index increased from 22.3+/-6.3% to 27.2+/-8.0% and from 2.3+/-0.5 ml/m2/min to 2.8+/-0.5 ml/m2/min, respectively (p<0.001). The endodiastolic volume index, endosystolic volume index and diastolic dimension decreased from 232.9+/-56.1 ml/m2 to 160.0+/-49.8 ml/m2, from 178.9+/-46.7 ml/m2 to 113.8+/-44.7 ml/m2 and from 82.0+/-9.0 mm to 68.9+/-11.6 mm, respectively (p<0.001). Late @entity1 occurred in 27 @entity0 with 22 @entity1 . The mean NYHA class was 1.7 among the survivors. One-, 3- and 5-year survival rates were 72.8%, 61.4% and 50.5%, respectively. In the 62 @entity0 who were non-inotropic dependent preoperatively, 1-, 3-, and 5-year survival rates (81.8%, 73.7% and 62.9%) were significantly better than the inotropic-dependent group (55.3%, 37.3% and 28.0%). @entity0 with mitral annuloplasty showed a significantly higher 5-year survival rate than @entity0 with mitral valve replacement (59.6% vs 43.6%) in univariate analysis. By application of the exclusion site selection method, the two different ventriculoplasty procedures did not show significant difference in survival rates. Multivariate analysis showed that preoperative inotropes and old age were significant predictors for postoperative mortality. CONCLUSION: The selected ventriculoplasty in combination with mitral annuloplasty is a useful option for @entity0 with an extremely dilated @entity5 in @entity4 . Surgery should be considered before inotropic dependency occurs when prior medical treatment has failed.

title: Selected ventriculoplasty for @entity4 with advanced XXXX : midterm results and risk analysis.

answer: @entity3


abstract: OBJECTIVE: Recently, the survival of @entity0 with @entity2 ( @entity2 ) has been prolonged with improvements in various diagnostic tools and medical treatment modalities. Consequently, spine @entity1 from @entity2 are being diagnosed more frequently. The accurate prediction of prognosis plays a critical role in determining a @entity0 's treatment plan, including surgery for @entity0 with spinal @entity1 of @entity2 . We investigated the clinical features, surgical outcomes, and prognostic factors of @entity2 presenting with spine @entity1 , in @entity0 who underwent surgery. METHODS: A retrospective review was conducted on 33 @entity2 @entity0 who underwent 36 operations (three @entity0 underwent surgical treatment twice) from February 2006 to December 2013. The median age of the @entity0 was 56 years old (range, 28 to 71; male : female=30 : 3). RESULTS: Overall survival was not correlated with age, sex, level of @entity1 , preoperative @entity0 -Pugh classification, preoperative ambulatory function, preoperative radiotherapy, type of operation, administration of @entity3 , or the Tokuhashi scoring system. Only the Tomita scoring system was shown to be an independent prognostic factor for overall survival. Comparing the @entity0 -Pugh classification and ambulatory ability, there were no statistically differences between @entity0 pre- and post-operatively. CONCLUSION: The Tomita scoring system represents a practicable and highly predictive prognostic tool. Even though surgical intervention may not restore ambulatory function, it should be considered to prevent deterioration of the @entity0 's overall condition. Additionally, aggressive management may be needed if there is any ambulatory ability remaining.

title: Survival-Related Factors of Spinal Metastasis with XXXX in Current Surgical Treatment Modalities : A Single Institute Experience.

answer: @entity2


abstract: BACKGROUND AND PURPOSE: For @entity1 , treatment options include external beam radiotherapy (EBRT), radical prostatectomy (RP), and brachytherapy (BT). @entity2 ( @entity2 ) is a common side-effect. Our aim was to evaluate penile @entity2 ( @entity2 ) before and after BT, EBRT, or RP using a validated self-administered quality-of-life survey from a prospective registry. MATERIAL AND METHODS: Analysis included 478 @entity0 undergoing RP (n   =   252), EBRT (n   =   91), and BT (n   =   135) with at least 1 year of follow-up and @entity2 documented using IIEF-5 scores at baseline, 6 weeks, 6 months, 1 year, and annually thereafter. RESULTS: Differences among treatments were most pronounced among @entity0 with no or mild initial @entity2 (IIEF-5   >=    17). Overall, corrected for baseline @entity2 and age, BT was associated with higher IIEF-5 scores than RP (+   7.8 IIEF-5 score) or EBRT (+   3.1 IIEF-5 score). EBRT was associated with better IIEF-5 scores than RP (+   4.7 IIEF-5 score). In @entity0 undergoing EBRT or RP with bilateral nerve sparing (NS), recovery of @entity2 was observed and during follow-up, the differences to BT were not statistically significant. Overall age had a negative impact on @entity2 preservation (corrected for baseline IIEF). CONCLUSION: In our series, @entity2 was adversely affected by each treatment modality. Considered overall, BT provided the best @entity2 preservation in comparison to EBRT or RP.

title: Erectile function following brachytherapy, external beam radiotherapy, or radical prostatectomy in XXXX @entity0 .

answer: @entity1