abstract: Previous studies have shown that @entity8 and serrated @entity3 of the colon show variable degrees of gastric and intestinal differentiation. MUCs are a class of approximately 20 genes that encode high-molecular-weight glycoproteins, or mucopolysaccharides, that are widely expressed in epithelial cells and show organ specificity. The role of MUC in serrated @entity1 is unknown. One previously published study suggested that expression of @entity11 is specific for sessile serrated @entity2 / @entity3 (SSA/Ps) and thus can be used to distinguish these lesions from @entity3 ( @entity3 ). However, data from our group suggest that MUC antibodies are not reliable in this differential diagnosis. The aims of this study were to systematically evaluate the expression of MUCs in serrated @entity5 and to determine the efficacy of MUC expression in differentiating @entity3 from SSA/Ps specifically. Routinely processed specimens from 182 serrated @entity3 [58 @entity3 , 46 SSA/Ps, 59 SSA/Ps with @entity4 ( @entity7 -D), 19 traditional serrated @entity2 , and 38 conventional tubular or tubulovillous @entity2 (CAs)] were immunohistochemically stained with @entity6 , @entity10 , @entity9 , and @entity11 , and scored for extent, intensity, and location of staining within the @entity3 . @entity3 were further subclassified into goblet cell type (N=18), microvesicular type (N=21), and mucin-depleted type (N=19). The data were compared between the different polyp groups and between @entity3 from different anatomic locations in the colon. @entity6 , @entity10 , @entity9 , and @entity11 were expressed in 27%, 100%, 100%, and 72% of serrated @entity3 overall. These antibodies were positive in 32%, 100%, 100%, and 43% of CAs. Expression levels of @entity6 , @entity10 , and @entity9 were not significantly different between any of the polyp subgroups or between serrated @entity3 and CAs. Both @entity7 and @entity7 -D showed a significantly higher percentage of @entity3 that stained with @entity11 , and a greater degree and intensity of staining for this peptide in comparison with @entity3 . Overall, 91% of SSA/Ps and 84% of @entity7 -Ds were positive for @entity11 in comparison with 60% of @entity3 (P<0.001 and P=0.02, respectively). Although @entity3 from both the left and right colon from each polyp group showed positivity for @entity11 , a significantly higher proportion of @entity7 -Ds and traditional serrated @entity2 from the right colon showed @entity11 positivity compared with those from the left. No differences were noted in @entity11 staining between each of the 3 HP subgroups. On the basis of these data, we conclude that @entity7 and @entity7 -D show increased expression of @entity11 compared with @entity3 ; however, because of overlap in the presence, degree, and intensity of staining, use of @entity11 to differentiate @entity3 from @entity7 or @entity7 -D in individual cases is not reliable because of a lack of specificity. Differences in @entity11 expression between right-sided and left-sided @entity5 supports the theory that there may be biological differences in the progression of @entity0 in different portions of the colon with regard to the serrated pathway of @entity1 .

title: MUC expression in XXXX and serrated @entity5 : lack of specificity of @entity11 .

answer: @entity8


abstract: Previous studies have shown that @entity8 and serrated @entity3 of the colon show variable degrees of gastric and intestinal differentiation. MUCs are a class of approximately 20 genes that encode high-molecular-weight glycoproteins, or mucopolysaccharides, that are widely expressed in epithelial cells and show organ specificity. The role of MUC in serrated @entity1 is unknown. One previously published study suggested that expression of @entity11 is specific for sessile serrated @entity2 / @entity3 (SSA/Ps) and thus can be used to distinguish these lesions from @entity3 ( @entity3 ). However, data from our group suggest that MUC antibodies are not reliable in this differential diagnosis. The aims of this study were to systematically evaluate the expression of MUCs in serrated @entity5 and to determine the efficacy of MUC expression in differentiating @entity3 from SSA/Ps specifically. Routinely processed specimens from 182 serrated @entity3 [58 @entity3 , 46 SSA/Ps, 59 SSA/Ps with @entity4 ( @entity7 -D), 19 traditional serrated @entity2 , and 38 conventional tubular or tubulovillous @entity2 (CAs)] were immunohistochemically stained with @entity6 , @entity10 , @entity9 , and @entity11 , and scored for extent, intensity, and location of staining within the @entity3 . @entity3 were further subclassified into goblet cell type (N=18), microvesicular type (N=21), and mucin-depleted type (N=19). The data were compared between the different polyp groups and between @entity3 from different anatomic locations in the colon. @entity6 , @entity10 , @entity9 , and @entity11 were expressed in 27%, 100%, 100%, and 72% of serrated @entity3 overall. These antibodies were positive in 32%, 100%, 100%, and 43% of CAs. Expression levels of @entity6 , @entity10 , and @entity9 were not significantly different between any of the polyp subgroups or between serrated @entity3 and CAs. Both @entity7 and @entity7 -D showed a significantly higher percentage of @entity3 that stained with @entity11 , and a greater degree and intensity of staining for this peptide in comparison with @entity3 . Overall, 91% of SSA/Ps and 84% of @entity7 -Ds were positive for @entity11 in comparison with 60% of @entity3 (P<0.001 and P=0.02, respectively). Although @entity3 from both the left and right colon from each polyp group showed positivity for @entity11 , a significantly higher proportion of @entity7 -Ds and traditional serrated @entity2 from the right colon showed @entity11 positivity compared with those from the left. No differences were noted in @entity11 staining between each of the 3 HP subgroups. On the basis of these data, we conclude that @entity7 and @entity7 -D show increased expression of @entity11 compared with @entity3 ; however, because of overlap in the presence, degree, and intensity of staining, use of @entity11 to differentiate @entity3 from @entity7 or @entity7 -D in individual cases is not reliable because of a lack of specificity. Differences in @entity11 expression between right-sided and left-sided @entity5 supports the theory that there may be biological differences in the progression of @entity0 in different portions of the colon with regard to the serrated pathway of @entity1 .

title: MUC expression in @entity8 and serrated XXXX : lack of specificity of @entity11 .

answer: @entity5


abstract: Previous studies have shown that @entity8 and serrated @entity3 of the colon show variable degrees of gastric and intestinal differentiation. MUCs are a class of approximately 20 genes that encode high-molecular-weight glycoproteins, or mucopolysaccharides, that are widely expressed in epithelial cells and show organ specificity. The role of MUC in serrated @entity1 is unknown. One previously published study suggested that expression of @entity11 is specific for sessile serrated @entity2 / @entity3 (SSA/Ps) and thus can be used to distinguish these lesions from @entity3 ( @entity3 ). However, data from our group suggest that MUC antibodies are not reliable in this differential diagnosis. The aims of this study were to systematically evaluate the expression of MUCs in serrated @entity5 and to determine the efficacy of MUC expression in differentiating @entity3 from SSA/Ps specifically. Routinely processed specimens from 182 serrated @entity3 [58 @entity3 , 46 SSA/Ps, 59 SSA/Ps with @entity4 ( @entity7 -D), 19 traditional serrated @entity2 , and 38 conventional tubular or tubulovillous @entity2 (CAs)] were immunohistochemically stained with @entity6 , @entity10 , @entity9 , and @entity11 , and scored for extent, intensity, and location of staining within the @entity3 . @entity3 were further subclassified into goblet cell type (N=18), microvesicular type (N=21), and mucin-depleted type (N=19). The data were compared between the different polyp groups and between @entity3 from different anatomic locations in the colon. @entity6 , @entity10 , @entity9 , and @entity11 were expressed in 27%, 100%, 100%, and 72% of serrated @entity3 overall. These antibodies were positive in 32%, 100%, 100%, and 43% of CAs. Expression levels of @entity6 , @entity10 , and @entity9 were not significantly different between any of the polyp subgroups or between serrated @entity3 and CAs. Both @entity7 and @entity7 -D showed a significantly higher percentage of @entity3 that stained with @entity11 , and a greater degree and intensity of staining for this peptide in comparison with @entity3 . Overall, 91% of SSA/Ps and 84% of @entity7 -Ds were positive for @entity11 in comparison with 60% of @entity3 (P<0.001 and P=0.02, respectively). Although @entity3 from both the left and right colon from each polyp group showed positivity for @entity11 , a significantly higher proportion of @entity7 -Ds and traditional serrated @entity2 from the right colon showed @entity11 positivity compared with those from the left. No differences were noted in @entity11 staining between each of the 3 HP subgroups. On the basis of these data, we conclude that @entity7 and @entity7 -D show increased expression of @entity11 compared with @entity3 ; however, because of overlap in the presence, degree, and intensity of staining, use of @entity11 to differentiate @entity3 from @entity7 or @entity7 -D in individual cases is not reliable because of a lack of specificity. Differences in @entity11 expression between right-sided and left-sided @entity5 supports the theory that there may be biological differences in the progression of @entity0 in different portions of the colon with regard to the serrated pathway of @entity1 .

title: MUC expression in @entity8 and serrated @entity5 : lack of specificity of XXXX .

answer: @entity11


abstract: @entity1 significanlty worsens the prognosis of many @entity7 , particularly in @entity0 with @entity6 . In 52 @entity0 , a continuous infusion of @entity3 , 1.5-2.5 micrograms/kg . min, was administered when @entity2 clearance (Ccr) fell below 40 ml/min and urinary output was less than 1 ml/kg . h despite normal intravascular volume. In 18 @entity0 , a continuous infusion of @entity5 (3-5 mg/kg . day) was also administered. Daily, two 3-h collections of urine and blood specimens were obtained to determine Ccr, osmolar clearance (Cosm), free water clearance ( @entity8 ) and excreted fraction of filtered @entity4 (FENa); one collection was made during @entity3 infusion and one while the infusion was suspended. Cardiac output and pulmonary venous admixture were also measured. The authors obtained 199 urine collections in 52 @entity0 ; considering the aggregate @entity0 pouplation, urinary output increased by 42.3% (30.2 +/- 3.45 (SEM) ml/h), on @entity3 infusion. Cosm, FENa, and Ccr were also higher on @entity3 . @entity8 and hemodynamic variables were not altered by @entity3 infusion. When @entity0 were startified on the basis of mechanical ventilatory support, Ccr and @entity5 administration, @entity3 infusion essentially caused the same changes in the variables studied as described for the aggregate @entity0 population. Diuresis and @entity4 excretion increased significantly on @entity3 even in those @entity0 receiving @entity5 infusion. The authors conclude that fluid and osmolar load can be eliminated more effectively in @entity7 @entity0 with continuous infusion of 1.5-2.5 micrograms/kg . min of @entity3 .

title: XXXX administration in oliguria and @entity1 .

answer: @entity3


abstract: @entity1 significanlty worsens the prognosis of many @entity7 , particularly in @entity0 with @entity6 . In 52 @entity0 , a continuous infusion of @entity3 , 1.5-2.5 micrograms/kg . min, was administered when @entity2 clearance (Ccr) fell below 40 ml/min and urinary output was less than 1 ml/kg . h despite normal intravascular volume. In 18 @entity0 , a continuous infusion of @entity5 (3-5 mg/kg . day) was also administered. Daily, two 3-h collections of urine and blood specimens were obtained to determine Ccr, osmolar clearance (Cosm), free water clearance ( @entity8 ) and excreted fraction of filtered @entity4 (FENa); one collection was made during @entity3 infusion and one while the infusion was suspended. Cardiac output and pulmonary venous admixture were also measured. The authors obtained 199 urine collections in 52 @entity0 ; considering the aggregate @entity0 pouplation, urinary output increased by 42.3% (30.2 +/- 3.45 (SEM) ml/h), on @entity3 infusion. Cosm, FENa, and Ccr were also higher on @entity3 . @entity8 and hemodynamic variables were not altered by @entity3 infusion. When @entity0 were startified on the basis of mechanical ventilatory support, Ccr and @entity5 administration, @entity3 infusion essentially caused the same changes in the variables studied as described for the aggregate @entity0 population. Diuresis and @entity4 excretion increased significantly on @entity3 even in those @entity0 receiving @entity5 infusion. The authors conclude that fluid and osmolar load can be eliminated more effectively in @entity7 @entity0 with continuous infusion of 1.5-2.5 micrograms/kg . min of @entity3 .

title: @entity3 administration in oliguria and XXXX .

answer: @entity1


abstract: PURPOSE: Ionizing radiation affects the proteome of irradiated cells and tissue, yet data concerning changes induced during @entity6 ( @entity6 ) in @entity0 blood are fragmentary and inconclusive. We aimed to identify features of serum proteome and associated processes involved in response to partial body irradiation during @entity1 treatment. METHODS AND MATERIALS: Twenty @entity0 with @entity2 ( @entity2 ) and 20 @entity0 with @entity4 received definitive intensity modulated @entity6 . Blood samples were collected before @entity6 , just after @entity6 , and 1  month after the end of @entity6 . Complete serum proteome was analyzed in individual samples, using a shotgun liquid chromatography-tandem mass spectrometry approach which allowed identification of approximately 450 proteins. Approximately 100 unique proteins were quantified in all samples after exclusion of immunoglobulins, and statistical significance of differences among consecutive samples was assessed. Processes associated with quantified proteins and their functional interactions were predicted using gene ontology tools. RESULTS: @entity6 -induced changes were marked in the @entity2 @entity0 group: 22 upregulated and 33 downregulated proteins were detected in post- @entity6 sera. Most of the changes reversed during follow-up, yet levels of some proteins remained affected 1  month after the end of @entity6 . @entity6 -upregulated proteins were associated with acute phase, inflammatory response, and complement activation. @entity6 -downregulated proteins were associated with transport and metabolism of lipids (plasma apolipoproteins) and @entity5 . @entity6 -induced changes were much weaker in @entity4 @entity0 , which corresponded to differences in acute radiation @entity3 observed in both groups. Nevertheless, general patterns of @entity6 -induced sera proteome changes were similar in both of the groups of @entity1 @entity0 . CONCLUSIONS: In this pilot study, we proposed to identify a molecular signature of radiation response, based on specific features of serum proteome. The signature included upregulation of factors involved in acute or inflammatory response but also downregulation of plasma apolipoproteins and factors involved in @entity5 .

title: Serum Proteome Signature of Radiation Response: Upregulation of Inflammation-Related Factors and Downregulation of Apolipoproteins and Coagulation Factors in XXXX @entity0 Treated With Radiation Therapy-A Pilot Study.

answer: @entity1


abstract: PURPOSE: Ionizing radiation affects the proteome of irradiated cells and tissue, yet data concerning changes induced during @entity6 ( @entity6 ) in @entity0 blood are fragmentary and inconclusive. We aimed to identify features of serum proteome and associated processes involved in response to partial body irradiation during @entity1 treatment. METHODS AND MATERIALS: Twenty @entity0 with @entity2 ( @entity2 ) and 20 @entity0 with @entity4 received definitive intensity modulated @entity6 . Blood samples were collected before @entity6 , just after @entity6 , and 1  month after the end of @entity6 . Complete serum proteome was analyzed in individual samples, using a shotgun liquid chromatography-tandem mass spectrometry approach which allowed identification of approximately 450 proteins. Approximately 100 unique proteins were quantified in all samples after exclusion of immunoglobulins, and statistical significance of differences among consecutive samples was assessed. Processes associated with quantified proteins and their functional interactions were predicted using gene ontology tools. RESULTS: @entity6 -induced changes were marked in the @entity2 @entity0 group: 22 upregulated and 33 downregulated proteins were detected in post- @entity6 sera. Most of the changes reversed during follow-up, yet levels of some proteins remained affected 1  month after the end of @entity6 . @entity6 -upregulated proteins were associated with acute phase, inflammatory response, and complement activation. @entity6 -downregulated proteins were associated with transport and metabolism of lipids (plasma apolipoproteins) and @entity5 . @entity6 -induced changes were much weaker in @entity4 @entity0 , which corresponded to differences in acute radiation @entity3 observed in both groups. Nevertheless, general patterns of @entity6 -induced sera proteome changes were similar in both of the groups of @entity1 @entity0 . CONCLUSIONS: In this pilot study, we proposed to identify a molecular signature of radiation response, based on specific features of serum proteome. The signature included upregulation of factors involved in acute or inflammatory response but also downregulation of plasma apolipoproteins and factors involved in @entity5 .

title: Serum Proteome Signature of Radiation Response: Upregulation of Inflammation-Related Factors and Downregulation of Apolipoproteins and Coagulation Factors in @entity1 XXXX Treated With Radiation Therapy-A Pilot Study.

answer: @entity0


abstract: We report a 1.7 kg male @entity0 with a @entity1 treated at an outside facility and referred to us on postoperative day 11. At presentation, his upper abdomen was distended, and he had perianal mucoid discharge. The tongue had a blackish discoloration. An erect abdominal radiograph showed a few fluid-filled bowel loops in the upper abdomen with a gasless lower abdomen and pelvis, suggestive of @entity3 . There were no specific radiological features of @entity6 . He underwent laparotomy and bowel resection for perforated jejunum. Histopathology of the tissue specimen was suggestive of @entity5 . Postoperatively, he received intravenous @entity4 (liposomal) and was started on liquid enteral nutrition after 2 weeks. However, the anterior two thirds of his tongue gradually sloughed off. He is awaiting reconstruction of the tongue. The purpose of this report is to emphasize that physicians should have a high index of suspicion for oral and gastrointestinal tract @entity5 in neonates with metabolic disturbances who present with a discolored oral mucosa and an abdominal mass with @entity2 . Early diagnosis and an aggressive approach of combined medical and surgical treatment may improve the outcome of @entity0 with this potentially lethal invasive disease.

title: Neonatal lingual and gastrointestinal mucormycosis in a case of XXXX -a rare presentation.

answer: @entity1


abstract: INTRODUCTION: The aims of this study were to compare microRNA (miR) expression between individuals with and without insulin resistance and to determine whether miRs predict response to @entity3 treatment. MATERIALS AND METHODS: In a sample of 93 healthy adults, insulin resistance was defined as steady state plasma @entity1 (SSPG)>= 180mg/dL and insulin sensitive as <120mg/dL. Response to @entity3 therapy was defined as >= 10% decrease in SSPG. We selected a panel of microRNAs based on prior evidence for a role in insulin or @entity1 metabolism. Fold change and Wilcoxon rank sum tests were calculated for the 25 miRs measured. RESULTS: At baseline, 81% (n=75) of @entity0 were insulin resistant. Five miRs were differentially expressed between the insulin resistant and sensitive groups: @entity9 (1.45 fold change (FC)), @entity2 (1.15 FC), @entity7 (1.36 FC), @entity6 (0.59 FC), and @entity5 (1.21 FC) (all p<0.05). In the subset who were insulin resistant at baseline and received @entity4 (n=47), 77% (n=36) showed improved insulin sensitivity. Six miRs were differentially expressed between responders compared to non-responders: miR-20b-5p (1.20 FC), @entity8 , (0.92 FC), miR-214-3p (1.13 FC), @entity2 (1.14 FC), @entity7 (0.98 FC), and @entity5 -5p (1.25 FC) (all p<0.05). DISCUSSION: This study is the first to report miRs associated with response to a pharmacologic intervention for insulin resistance. @entity7 and @entity5 -5p identified responders to @entity3 therapy among the insulin resistant group.

title: Circulating XXXX and microRNA-486 predict @entity3 response: Moving towards precision health for diabetes prevention.

answer: @entity7


abstract: INTRODUCTION: The aims of this study were to compare microRNA (miR) expression between individuals with and without insulin resistance and to determine whether miRs predict response to @entity3 treatment. MATERIALS AND METHODS: In a sample of 93 healthy adults, insulin resistance was defined as steady state plasma @entity1 (SSPG)>= 180mg/dL and insulin sensitive as <120mg/dL. Response to @entity3 therapy was defined as >= 10% decrease in SSPG. We selected a panel of microRNAs based on prior evidence for a role in insulin or @entity1 metabolism. Fold change and Wilcoxon rank sum tests were calculated for the 25 miRs measured. RESULTS: At baseline, 81% (n=75) of @entity0 were insulin resistant. Five miRs were differentially expressed between the insulin resistant and sensitive groups: @entity9 (1.45 fold change (FC)), @entity2 (1.15 FC), @entity7 (1.36 FC), @entity6 (0.59 FC), and @entity5 (1.21 FC) (all p<0.05). In the subset who were insulin resistant at baseline and received @entity4 (n=47), 77% (n=36) showed improved insulin sensitivity. Six miRs were differentially expressed between responders compared to non-responders: miR-20b-5p (1.20 FC), @entity8 , (0.92 FC), miR-214-3p (1.13 FC), @entity2 (1.14 FC), @entity7 (0.98 FC), and @entity5 -5p (1.25 FC) (all p<0.05). DISCUSSION: This study is the first to report miRs associated with response to a pharmacologic intervention for insulin resistance. @entity7 and @entity5 -5p identified responders to @entity3 therapy among the insulin resistant group.

title: Circulating @entity7 and microRNA-486 predict XXXX response: Moving towards precision health for diabetes prevention.

answer: @entity3


abstract: OBJECTIVES: To compare two cervical @entity1 screening methods: community-based self-collection of high-risk @entity2 (HR-HPV) testing and visual inspection with @entity3 (VIA). METHODS: Pilot randomised controlled trial of 500 @entity0 aged 30-65 in the community of Kisenyi, Uganda. @entity0 randomised to self-collection-based HR-HPV testing provided a cervico-vaginal swab for HR-HPV, and results were provided by phone after laboratory testing. @entity0 who tested HPV positive were referred for VIA at the local health unit. @entity0 randomised to VIA underwent screening at the local health unit, where @entity0 who tested positive with VIA were provided cryotherapy at time of screening, as per local standard of care. @entity0 were referred for colposcopy when indicated. Outcome measures were uptake of screening, HR-HPV prevalence, VIA result and treatment rates. RESULTS: In the HR-HPV arm, 248 of 250 (p  <  0.01) @entity0 provided samples, while in the VIA arm, 121 of 250 (48.4%) @entity0 attended screening. Among the 73 of 248 HR-HPV-positive @entity0 , 45.2% (N  =  33) attended VIA screening for follow-up, 21.2% (N  =  7) of whom screened positive; five received treatment and two were missing clinical follow-up records. Of the 121 @entity0 in the VIA arm who attended screening, 13.2% (N  =  16) screened positive; seven received cryotherapy, three refused treatment, five were referred to colposcopy; and one @entity0 had suspected cervical @entity1 and received treatment after confirmatory testing. CONCLUSIONS: This pilot study demonstrated trial feasibility and willingness of the @entity0 to participate and be randomised successfully into the two arms. Self-collection-based cervical @entity1 screening had a higher uptake than VIA.

title: Uptake of community-based, self-collected HPV testing vs. visual inspection with XXXX for cervical @entity1 screening in Kampala, Uganda: preliminary results of a randomised controlled trial.

answer: @entity3


abstract: OBJECTIVES: To compare two cervical @entity1 screening methods: community-based self-collection of high-risk @entity2 (HR-HPV) testing and visual inspection with @entity3 (VIA). METHODS: Pilot randomised controlled trial of 500 @entity0 aged 30-65 in the community of Kisenyi, Uganda. @entity0 randomised to self-collection-based HR-HPV testing provided a cervico-vaginal swab for HR-HPV, and results were provided by phone after laboratory testing. @entity0 who tested HPV positive were referred for VIA at the local health unit. @entity0 randomised to VIA underwent screening at the local health unit, where @entity0 who tested positive with VIA were provided cryotherapy at time of screening, as per local standard of care. @entity0 were referred for colposcopy when indicated. Outcome measures were uptake of screening, HR-HPV prevalence, VIA result and treatment rates. RESULTS: In the HR-HPV arm, 248 of 250 (p  <  0.01) @entity0 provided samples, while in the VIA arm, 121 of 250 (48.4%) @entity0 attended screening. Among the 73 of 248 HR-HPV-positive @entity0 , 45.2% (N  =  33) attended VIA screening for follow-up, 21.2% (N  =  7) of whom screened positive; five received treatment and two were missing clinical follow-up records. Of the 121 @entity0 in the VIA arm who attended screening, 13.2% (N  =  16) screened positive; seven received cryotherapy, three refused treatment, five were referred to colposcopy; and one @entity0 had suspected cervical @entity1 and received treatment after confirmatory testing. CONCLUSIONS: This pilot study demonstrated trial feasibility and willingness of the @entity0 to participate and be randomised successfully into the two arms. Self-collection-based cervical @entity1 screening had a higher uptake than VIA.

title: Uptake of community-based, self-collected HPV testing vs. visual inspection with @entity3 for cervical XXXX screening in Kampala, Uganda: preliminary results of a randomised controlled trial.

answer: @entity1


abstract: PURPOSE: We describe the presentation, endovascular management and functional outcomes of 15 @entity0 with renal arterial @entity7 following open and laparoscopic partial nephrectomy. MATERIALS AND METHODS: An institutional review board approved, Health Insurance Portability and Accountability Act compliant retrospective review of a prospectively maintained database revealed that 7 of 1,160 @entity0 who underwent open partial nephrectomy and 8 of 301 treated with laparoscopic partial nephrectomy were diagnosed with a @entity7 of a renal artery branch between 2003 and 2010. Some cases were associated with @entity6 . RESULTS: Diagnosis of @entity7 was made a median of 14 days after surgery. Gross @entity4 was the most frequent symptom. Median estimated glomerular filtration rate measurements at the preoperative evaluation, postoperatively, on the day the vascular lesion was diagnosed, after embolization and at the last followup were 62, 55, 55, 56 and 58 ml/minute/1.73 m(2), respectively. Median followup was 7.8 months. All @entity0 underwent angiography and superselective coil embolization of 1 or more @entity7 with or without @entity6 . Eleven @entity0 had immediate cessation of symptoms while 4 had persistent gross @entity4 after the procedure. Of these 4 @entity0 2 were treated with bedside care, 1 required repeat embolization with @entity3 , which was successful, and the remaining @entity0 had @entity5 and underwent radical nephrectomy for persistent @entity2 . CONCLUSIONS: @entity7 and @entity1 are rare complications of partial nephrectomy. Presentation is often delayed. Superselective coil embolization is a safe, minimally invasive treatment option that usually solves the clinical problem and preserves renal function.

title: Selective arterial embolization for @entity7 and XXXX following partial nephrectomy.

answer: @entity1


abstract: PURPOSE: We describe the presentation, endovascular management and functional outcomes of 15 @entity0 with renal arterial @entity7 following open and laparoscopic partial nephrectomy. MATERIALS AND METHODS: An institutional review board approved, Health Insurance Portability and Accountability Act compliant retrospective review of a prospectively maintained database revealed that 7 of 1,160 @entity0 who underwent open partial nephrectomy and 8 of 301 treated with laparoscopic partial nephrectomy were diagnosed with a @entity7 of a renal artery branch between 2003 and 2010. Some cases were associated with @entity6 . RESULTS: Diagnosis of @entity7 was made a median of 14 days after surgery. Gross @entity4 was the most frequent symptom. Median estimated glomerular filtration rate measurements at the preoperative evaluation, postoperatively, on the day the vascular lesion was diagnosed, after embolization and at the last followup were 62, 55, 55, 56 and 58 ml/minute/1.73 m(2), respectively. Median followup was 7.8 months. All @entity0 underwent angiography and superselective coil embolization of 1 or more @entity7 with or without @entity6 . Eleven @entity0 had immediate cessation of symptoms while 4 had persistent gross @entity4 after the procedure. Of these 4 @entity0 2 were treated with bedside care, 1 required repeat embolization with @entity3 , which was successful, and the remaining @entity0 had @entity5 and underwent radical nephrectomy for persistent @entity2 . CONCLUSIONS: @entity7 and @entity1 are rare complications of partial nephrectomy. Presentation is often delayed. Superselective coil embolization is a safe, minimally invasive treatment option that usually solves the clinical problem and preserves renal function.

title: Selective arterial embolization for XXXX and @entity1 following partial nephrectomy.

answer: @entity7


abstract: PURPOSE: In 2010 the American Joint Committee on Cancer updated the @entity2 @entity3 classification. Without independent validation of the new classification its predictive ability for @entity1 specific survival and generalizability remains unknown. In this setting we determined the predictive ability of the 2010 @entity3 classification compared to that of the 2002 classification. MATERIALS AND METHODS: Using the nephrectomy registry at our institution we retrospectively reviewed the records of 3,996 @entity0 with unilateral or bilateral @entity2 treated with radical nephrectomy or nephron sparing surgery between 1970 and 2006. Cancer specific survival was estimated using the Kaplan-Meier method and predictive ability was evaluated using the concordance index. RESULTS: There were 1,165 deaths (29.1%) from @entity2 a median of 1.9 years after surgery compared to a median followup of 7.4 years for survivors. The estimated 10-year @entity1 specific survival rate was 96%, 80%, 66%, 55%, 36%, 26%, 25% and 12% for @entity0 with 2010 @entity1 classifications of pT1a, pT1b, pT2a, pT2b, pT3a, pT3b, pT3c and pT4, respectively (p <0.001). The multivariate concordance index for the 2002 and 2010 @entity3 classifications was 0.848 and 0.850, respectively. CONCLUSIONS: The new 2010 classification remains a robust predictor of @entity1 specific survival compared to the 2002 classification by dividing pT2 lesions into pT2a and pT2b, reclassifying ipsilateral adrenal involvement as pT4, reclassifying renal vein involvement as pT3a and simplifying nodal involvement as pN0 vs @entity4 . However, the 2010 @entity3 classification showed only modest improvement in predictive ability compared to the 2002 classification.

title: Independent validation of the 2010 American Joint Committee on Cancer @entity3 classification for XXXX : results from a large, single institution cohort.

answer: @entity2


abstract: PURPOSE: In 2010 the American Joint Committee on Cancer updated the @entity2 @entity3 classification. Without independent validation of the new classification its predictive ability for @entity1 specific survival and generalizability remains unknown. In this setting we determined the predictive ability of the 2010 @entity3 classification compared to that of the 2002 classification. MATERIALS AND METHODS: Using the nephrectomy registry at our institution we retrospectively reviewed the records of 3,996 @entity0 with unilateral or bilateral @entity2 treated with radical nephrectomy or nephron sparing surgery between 1970 and 2006. Cancer specific survival was estimated using the Kaplan-Meier method and predictive ability was evaluated using the concordance index. RESULTS: There were 1,165 deaths (29.1%) from @entity2 a median of 1.9 years after surgery compared to a median followup of 7.4 years for survivors. The estimated 10-year @entity1 specific survival rate was 96%, 80%, 66%, 55%, 36%, 26%, 25% and 12% for @entity0 with 2010 @entity1 classifications of pT1a, pT1b, pT2a, pT2b, pT3a, pT3b, pT3c and pT4, respectively (p <0.001). The multivariate concordance index for the 2002 and 2010 @entity3 classifications was 0.848 and 0.850, respectively. CONCLUSIONS: The new 2010 classification remains a robust predictor of @entity1 specific survival compared to the 2002 classification by dividing pT2 lesions into pT2a and pT2b, reclassifying ipsilateral adrenal involvement as pT4, reclassifying renal vein involvement as pT3a and simplifying nodal involvement as pN0 vs @entity4 . However, the 2010 @entity3 classification showed only modest improvement in predictive ability compared to the 2002 classification.

title: Independent validation of the 2010 American Joint Committee on Cancer XXXX classification for @entity2 : results from a large, single institution cohort.

answer: @entity3


abstract: PURPOSE: The MHCC97 cell line contains two clones with high (MHCC97-H) and low (MHCC97-L) metastatic potentials, for which the pulmonary metastatic rate was 100% vs 40% between the two @entity0 @entity3 ( @entity3 ) clones. In an effort to elucidate the mechanism of organ-specific @entity1 , we studied the effect of lung extracts from C57BL/6 @entity2 on migration and invasion using the MHCC97 cell line. METHODS: Determination of migration and invasion induced by lung extracts to MHCC97 cell lines was examined by chemoinvasion assay. The organization of cytoskeleton was tested using filamentous actin (F-actin) polymerization assay and flow cytometry. The activity of matrix metalloproteinase (MMPs) was analyzed by zymogram. Fluorescence double staining was employed for MMPs and F-actin colocalization in MHCC97-H cells induced by lung extracts. RESULTS: The number of cells in response to extracts of lung, liver, kidney, and spleen in MHCC97-H cells was 64+/-10, 6+/-2, 22+/-4, and 3+/-1, respectively. Of the extracts, lung extracts showed significant differences to promote the migratory and invasive ability for MHCC97-H cells( p<0.001). The number of cells in response to lung extracts was threefold higher in MHCC97-H than that of cells in MHCC97-L ( p<0.001). Confocal laser scan microscope of MHCC97-H cells and MHCC97-L cells stimulated with lung extracts revealed pseudopodia formation around the cell front at the indicated time point. With the time increasing, the pseudopodia formation became increasingly more obvious and distinct. Compared with unstimulated cells, analysis of FACS showed a transient 1.9-fold and 1.7-fold increase in F-actin within 30 s in MHCC97-H cells and MHCC97-L cells, respectively. Confocal laser scan microscopy of MHCC97-H cells stimulated in suspension with lung extracts revealed intense F-actin staining in the periphery of the cells and redistribution of F-actin towards a leading edge. After the cells were incubated with lung extracts, not only expressions of active and latent form of @entity5 were upregulated, but that of latent form of @entity4 was increased in the MHCC97-H cells and MHCC97-L cells. The levels of latent and active form of @entity5 (18.8+/-1.2, 100.1+/-1.1), and latent form of @entity4 (22.4+/-1.3) were much higher in MHCC97-H cells than those of MHCC97-L cells, which were 7.8+/-0.3, 40.8+/-2.2, and 8.2+/-0.4, respectively. @entity5 was mainly localized perinuclear pool when the MHCC97-H cells were incubated with serum-free medium. After the cells were stimulated with lung extracts, @entity5 were expressed and colocalized with F-actin at the front of extending pseudopodia. CONCLUSIONS: Our results indicate that the expression of matrix metalloproteinase and the pseudopodia formation in MHCC97-H cells may correlate to the metastatic potential; thus, the host environment may contribute to the preferential @entity1 of @entity3 cells to the lung depending on the high level of @entity5 and migratory ability.

title: Contributions of lung tissue extracts to invasion and migration of @entity0 XXXX cells with various metastatic potentials.

answer: @entity3


abstract: PURPOSE: The MHCC97 cell line contains two clones with high (MHCC97-H) and low (MHCC97-L) metastatic potentials, for which the pulmonary metastatic rate was 100% vs 40% between the two @entity0 @entity3 ( @entity3 ) clones. In an effort to elucidate the mechanism of organ-specific @entity1 , we studied the effect of lung extracts from C57BL/6 @entity2 on migration and invasion using the MHCC97 cell line. METHODS: Determination of migration and invasion induced by lung extracts to MHCC97 cell lines was examined by chemoinvasion assay. The organization of cytoskeleton was tested using filamentous actin (F-actin) polymerization assay and flow cytometry. The activity of matrix metalloproteinase (MMPs) was analyzed by zymogram. Fluorescence double staining was employed for MMPs and F-actin colocalization in MHCC97-H cells induced by lung extracts. RESULTS: The number of cells in response to extracts of lung, liver, kidney, and spleen in MHCC97-H cells was 64+/-10, 6+/-2, 22+/-4, and 3+/-1, respectively. Of the extracts, lung extracts showed significant differences to promote the migratory and invasive ability for MHCC97-H cells( p<0.001). The number of cells in response to lung extracts was threefold higher in MHCC97-H than that of cells in MHCC97-L ( p<0.001). Confocal laser scan microscope of MHCC97-H cells and MHCC97-L cells stimulated with lung extracts revealed pseudopodia formation around the cell front at the indicated time point. With the time increasing, the pseudopodia formation became increasingly more obvious and distinct. Compared with unstimulated cells, analysis of FACS showed a transient 1.9-fold and 1.7-fold increase in F-actin within 30 s in MHCC97-H cells and MHCC97-L cells, respectively. Confocal laser scan microscopy of MHCC97-H cells stimulated in suspension with lung extracts revealed intense F-actin staining in the periphery of the cells and redistribution of F-actin towards a leading edge. After the cells were incubated with lung extracts, not only expressions of active and latent form of @entity5 were upregulated, but that of latent form of @entity4 was increased in the MHCC97-H cells and MHCC97-L cells. The levels of latent and active form of @entity5 (18.8+/-1.2, 100.1+/-1.1), and latent form of @entity4 (22.4+/-1.3) were much higher in MHCC97-H cells than those of MHCC97-L cells, which were 7.8+/-0.3, 40.8+/-2.2, and 8.2+/-0.4, respectively. @entity5 was mainly localized perinuclear pool when the MHCC97-H cells were incubated with serum-free medium. After the cells were stimulated with lung extracts, @entity5 were expressed and colocalized with F-actin at the front of extending pseudopodia. CONCLUSIONS: Our results indicate that the expression of matrix metalloproteinase and the pseudopodia formation in MHCC97-H cells may correlate to the metastatic potential; thus, the host environment may contribute to the preferential @entity1 of @entity3 cells to the lung depending on the high level of @entity5 and migratory ability.

title: Contributions of lung tissue extracts to invasion and migration of XXXX @entity3 cells with various metastatic potentials.

answer: @entity0


abstract: AIM: During adult @entity2 , rescuers frequently provide ventilations at rates exceeding those recommended by the @entity1 ( @entity1 ). Excessive ventilation is associated with worse clinical outcome after adult @entity2 . This study is the first to characterize ventilation rate adherence to @entity1 guidelines during in-hospital pediatric @entity2 resuscitation. @entity0 AND METHODS: We prospectively enrolled @entity0 and adolescents (>= 8 years of age) who suffered a @entity2 in a pediatric intensive care unit (PICU) or emergency department (ED) of a tertiary-care pediatric hospital. Ventilation rate (breaths per minute [bpm]) was monitored via changes in chest wall impedance (CWI) recorded by defibrillator electrode pads during cardiopulmonary resuscitation (CPR). RESULTS: Twenty-four CPR events were enrolled yielding 588 thirty-second CPR epochs. The proportion of CPR epochs with ventilation rates exceeding @entity1 guidelines (>10 bpm) was 63% (CI(95) 59-67%), significantly higher than our a priori hypothesis of 30% (p<0.01). The proportion of CPR epochs with ventilation rates exceeding 20 bpm was 20% (CI(95) 17-23). After controlling for location of arrest and initial event rhythm, resuscitations that occurred on nights/weekends were 3.6 times (CI(95): 1.6-7.9, p<0.01) more likely to have a ventilation rate exceeding @entity1 guidelines. CONCLUSIONS: During in-hospital pediatric @entity2 , rescuers frequently provide artificial ventilations at rates in excess of @entity1 guidelines, with twenty percent of CPR time having ventilation rates double that recommended. Excessive ventilation was particularly common during CPR events that occurred on nights/weekends.

title: The first quantitative report of ventilation rate during in-hospital resuscitation of older XXXX and adolescents.

answer: @entity0


abstract: Reconstructive microsurgical procedures are getting more common in @entity1 @entity0 . Adjuvant therapies, such as chemotherapy, radiotherapy, and immune therapy, are usually combined with surgical approaches to improve outcomes. This study was designed to investigate the effects of preoperative chemotherapy on healing in microvascular @entity3 . As a commonly preferred drug for neoadjuvant @entity1 treatment, @entity5 was used on @entity2 in our study. Ninety-three @entity2 were used and randomly allocated into two groups as 72 experimental and 21 control @entity2 . @entity5 2 mg/kg was administered as a single dose intraperitoneally on day 0 in the experimental group. Leukocytes and erythrocytes were counted on days 0, 1, 3, 5, 7, 10, and 15 in 6 @entity2 of the experimental and 6 @entity2 of the control group. We found that the @entity4 period ended on approximately day 7. After applying the medication, the experimental group (n = 72) was divided into three main groups (n = 24). We performed end-to-end femoral artery @entity3 on days 7 or 14 or 21, respectively, in each group. Each main group was divided into three subgroups (n = 8), and then we tested patency and took biopsies on days 7 or 14 or 21, respectively, in each subgroup. Histopathologic evaluation was carried out. The comparison of patency tests and pathologic examination indicated that there was no statistically significant difference between the two groups.

title: Effects of @entity5 on healing in microvascular XXXX .

answer: @entity3


abstract: Reconstructive microsurgical procedures are getting more common in @entity1 @entity0 . Adjuvant therapies, such as chemotherapy, radiotherapy, and immune therapy, are usually combined with surgical approaches to improve outcomes. This study was designed to investigate the effects of preoperative chemotherapy on healing in microvascular @entity3 . As a commonly preferred drug for neoadjuvant @entity1 treatment, @entity5 was used on @entity2 in our study. Ninety-three @entity2 were used and randomly allocated into two groups as 72 experimental and 21 control @entity2 . @entity5 2 mg/kg was administered as a single dose intraperitoneally on day 0 in the experimental group. Leukocytes and erythrocytes were counted on days 0, 1, 3, 5, 7, 10, and 15 in 6 @entity2 of the experimental and 6 @entity2 of the control group. We found that the @entity4 period ended on approximately day 7. After applying the medication, the experimental group (n = 72) was divided into three main groups (n = 24). We performed end-to-end femoral artery @entity3 on days 7 or 14 or 21, respectively, in each group. Each main group was divided into three subgroups (n = 8), and then we tested patency and took biopsies on days 7 or 14 or 21, respectively, in each subgroup. Histopathologic evaluation was carried out. The comparison of patency tests and pathologic examination indicated that there was no statistically significant difference between the two groups.

title: Effects of XXXX on healing in microvascular @entity3 .

answer: @entity5


abstract: @entity6 ( @entity6 ) binds to its receptor, @entity12 , on the surface of @entity1 cells, leading to the formation of plasmin. @entity4 ( @entity4 ) cell lines secrete high levels of @entity9 ), suggesting autocrine IGFs play a major role in the unregulated growth and @entity0 of @entity4 . In vitro, @entity9 and @entity2 increased @entity7 of RD cells to 124+/-9% (P<0.01) and 131+/-8% (P<0.05) of control, respectively. @entity9 -induced @entity7 was abolished by @entity14 ( @entity14 ) (P<0.01), a relatively specific inhibitor of @entity9 , and by @entity5 ( @entity5 ) (P<0.05). Aprotinin, a plasmin inhibitor, and @entity15 , which inhibits the synthesis of @entity8 (GPI), thereby preventing anchorage of GPI-linked proteins such as @entity12 to the cell membrane, also decreased @entity9 - (P<0.05 for both) but not @entity2 -induced @entity7 . [ @entity3 54, @entity3 55] @entity9 and [Leu27] @entity9 , which preferentially bind to the @entity2 and @entity9 / @entity10 receptors ( @entity9 / @entity16 ), respectively, both induced RD cell @entity7 to 146+/-8% (P<0.01) and 120+/-7% (P<0.05) of control, respectively. An anti- @entity12 anti-serum reduced @entity9 - and @entity2 -induced @entity7 (P<0.05 for both). An anti-low density @entity11 ( @entity11 ) anti-serum reduced @entity2 -induced @entity7 (P<0.05). @entity13 both increased specific 125I-single chain @entity6 (scuPA) binding to RD cells in a dose-dependent manner (P<0.01). These results suggest involvement of the PA/plasmin system in IGF-induced @entity7 and indicate important roles these systems may have in @entity4 @entity0 .

title: Urokinase type plasminogen activator receptor is involved in insulin-like growth factor-induced @entity7 of XXXX cells in vitro.

answer: @entity4


abstract: @entity6 ( @entity6 ) binds to its receptor, @entity12 , on the surface of @entity1 cells, leading to the formation of plasmin. @entity4 ( @entity4 ) cell lines secrete high levels of @entity9 ), suggesting autocrine IGFs play a major role in the unregulated growth and @entity0 of @entity4 . In vitro, @entity9 and @entity2 increased @entity7 of RD cells to 124+/-9% (P<0.01) and 131+/-8% (P<0.05) of control, respectively. @entity9 -induced @entity7 was abolished by @entity14 ( @entity14 ) (P<0.01), a relatively specific inhibitor of @entity9 , and by @entity5 ( @entity5 ) (P<0.05). Aprotinin, a plasmin inhibitor, and @entity15 , which inhibits the synthesis of @entity8 (GPI), thereby preventing anchorage of GPI-linked proteins such as @entity12 to the cell membrane, also decreased @entity9 - (P<0.05 for both) but not @entity2 -induced @entity7 . [ @entity3 54, @entity3 55] @entity9 and [Leu27] @entity9 , which preferentially bind to the @entity2 and @entity9 / @entity10 receptors ( @entity9 / @entity16 ), respectively, both induced RD cell @entity7 to 146+/-8% (P<0.01) and 120+/-7% (P<0.05) of control, respectively. An anti- @entity12 anti-serum reduced @entity9 - and @entity2 -induced @entity7 (P<0.05 for both). An anti-low density @entity11 ( @entity11 ) anti-serum reduced @entity2 -induced @entity7 (P<0.05). @entity13 both increased specific 125I-single chain @entity6 (scuPA) binding to RD cells in a dose-dependent manner (P<0.01). These results suggest involvement of the PA/plasmin system in IGF-induced @entity7 and indicate important roles these systems may have in @entity4 @entity0 .

title: Urokinase type plasminogen activator receptor is involved in insulin-like growth factor-induced XXXX of @entity4 cells in vitro.

answer: @entity7


abstract: BACKGROUND: The potential progression from intestinal metaplasia to @entity3 , to high grade @entity8 and to @entity7 represents a well recognized sequence in @entity0 with @entity6 ( @entity6 ). The time required for this transformation is not well known. AIM: To report the results of a 10 years follow up of @entity0 with @entity6 . MATERIAL AND METHODS: Between 1989 and 2000 we followed 402 @entity0 with @entity6 . RESULTS: Sixty six subjects (16.2%) presented @entity3 at the time of diagnosis and 10 @entity0 (2 @entity0 /8 @entity0 ) developed @entity7 during the follow-up period. Four out of these 10 @entity0 were operated because of @entity5 , but after 3-5 years, @entity4 recurred. The other 6 @entity0 rejected surgery and were on @entity9 with good symptomatic results. Two @entity0 had a short @entity6 (< 3 cm), seven cases had a classic @entity6 (3-10 cm) and one @entity0 had an extensive > 10 cm @entity6 . The mean time elapsed from intestinal metaplasia to @entity3 was 9 months, to high grade @entity8 56 months and to @entity7 82 months. From @entity3 to early @entity1 it was 18 months, from high grade @entity8 to early @entity1 14 months and from high grade @entity8 to advanced transmural @entity1 14 months. All @entity0 were subjected to esophagectomy. Five @entity0 detected as State I are alive without any evidence of recurrence after 36 to 130 months after surgery. Five @entity0 with advanced transmural @entity2 subjected to radical esophagectomy died because of progression of the malignancy between 3 and 24 months after surgery. CONCLUSIONS: Progression to @entity7 may occur even in absence of @entity4 while on acid suppression therapy. Detection at early stage intestinal metaplasia in the esophagus offers a high chance of cure after surgical resection.

title: [Progression from intestinal metaplasia to XXXX in Barrett s esophagus: usefulness of endoscopic surveillance].

answer: @entity7


abstract: During the period from 1989 till 1998 local @entity5 injection therapy (LEIT) was used in treatment of 37 @entity0 aged 39-78. The multiple focused form of @entity4 was observed in 15 (41%) @entity0 , solitary in 20 (54%), the diffuse-focused in 2 (5%) @entity0 . The distribution of the @entity1 according to the histological structure was as follows: @entity6 in 22 (60%) @entity0 , capillary--in 2 (5%) @entity0 , mixed in 13 (35%). Local injection therapy was the only method of treatment of 17 @entity0 . In 13 @entity0 this method gave insufficiently effective embolization of the hepatic artery, in 2 @entity0 the injection therapy was combined with ligation of the hepatic artery and in 5 @entity0 --with resection of the liver because of another @entity1 . The volume of a single use of @entity5 varied from 6 to 60 ml. Long-term results were followed-up during 3-6 years. By the data of USI, CT, NMR in all the @entity0 there were changes in the @entity1 typical of @entity2 . Positive results of the treatment such as a reduced size of @entity7 were noted in 27 @entity0 (73.0%), @entity3 disappeared in 10 out of 29 @entity0 (35%) who had @entity3 syndrome. A conclusion is made that local @entity5 injection therapy with 96% @entity5 is effective in treatment of @entity4 . It gives good long-term results including a combination with the endovascular treatment and resection of the liver.

title: [Long-term results of local XXXX injection therapy in the treatment of hemangiomatosis of the liver].

answer: @entity5


abstract: OBJECTIVE: To validate a translated Italian version of the @entity2 Impact Questionnaire (FIQ). METHODS: The Italian version of the FIQ was administered to 50 @entity0 affected by @entity2 ( @entity2 ) (48 @entity0 filled out the questionnaire again 10 days later) together with the Italian version of the Stanford Health Assessment Questionnaire (HAQ), the Medical Outcomes Survey Short Form-36 (SF-36), and a @entity3 ( @entity3 ) obtained by summing the score (0-3) of each tender point tested by thumb palpation. All @entity0 were asked about the severity of @entity1 today (10 cm visual analog scale) and the duration of symptoms. Test-retest reliability was assessed using Spearman correlations. Internal consistency was evaluated with Cronbach's alpha of reliability. Construct validity of the FIQ was evaluated by correlations between the HAQ and subscales of the SF-36 as well as the @entity3 . RESULTS: The mean duration of symptoms was 6.5 years and the mean age of the @entity0 was 57.4 years. Test-retest reliability was between 0.74 and 0.95 for physical functioning as well as for the total FIQ and other components. Internal consistency was 0.90 for the overall FIQ. Significant correlations were obtained between the FIQ items, the HAQ and the SF-36. CONCLUSIONS: The Italian FIQ is a reliable and valid instrument for detecting and measuring functional disability and health status in Italian @entity0 with @entity2 .

title: Validation of an Italian version of the XXXX Impact Questionnaire (FIQ-I).

answer: @entity2


abstract: @entity4 is a severe @entity1 that is caused by mutations in the @entity0 @entity5 ( @entity5 ) gene. @entity6 protein is required for the assembly of small nuclear ribonucleoproteins and a dramatic reduction of the protein leads to cell death. It is currently unknown how the reduction of this ubiquitously essential protein can lead to tissue-specific abnormalities. In addition, it is still not known whether the disease is caused by developmental or @entity2 . Using the @entity3 system, we show that @entity6 is enriched in postembryonic neuroblasts and forms a concentration gradient in the differentiating progeny. In addition to the developing @entity3 larval CNS, @entity3 larval and adult testes have a striking @entity6 gradient. When @entity6 is reduced in postembryonic neuroblasts using MARCM clonal analysis, cell proliferation and clone formation defects occur. These @entity6 mutant neuroblasts fail to correctly localise Miranda and have reduced levels of snRNAs. When @entity6 is removed, germline stem cells are lost more frequently. We also show that changes in @entity6 levels can disrupt the correct timing of cell differentiation. We conclude that highly regulated @entity6 levels are essential to drive timely cell proliferation and cell differentiation.

title: Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in XXXX .

answer: @entity3


abstract: This case report describes the unilateral acute @entity2 in the right eye of a 48-year-old @entity0 . The @entity0 was otherwise healthy but 2 days previously had suffered from @entity2 . Secondary to this, the @entity0 had already been under dental treatment for 1 week due to @entity1 . At the first examination a macular branch @entity6 and @entity5 were found in the right eye by indirect ophthalmoscopy. The immediate diagnostic procedure identified @entity4 (AML) as the cause of the vascular pathology. The AML can be manifested in different ways and the retina is involved in approximately 50% of cases. Due to a @entity7 , which is found in approx. 20% of @entity4 , symptomatic central @entity6 or macular branch @entity6 can occur. Ophthalmic symptoms can be the first and only signs to be detected. Therefore, ophthalmologists should also consider a @entity3 and initiate a clarification. A differential blood count is indispensable. The results usually improve by a rapidly arranged and suitable therapy. Ophthalmological follow-up examinations are imperative as an initiated chemotherapy can also produce ophthalmological side-effects.

title: [Gingival hyperplasia and XXXX ].

answer: @entity2


abstract: The authors present a retrospective clinical analysis of 25 operated @entity0 with @entity1 and severe cholecystopancreatitis. The severity of the disease was evaluated by the Ranson scale. Diagnosis was made using all available contemporary diagnostic methods. Eleven of the @entity0 were operated in the first 2-5 days after admission because of severe form of acute @entity1 resisting medical therapy (Ranson > 3) and 8 @entity0 with @entity1 underwent surgery within 2-3 weeks after the disease onset. Five of the @entity0 died (26.32%). Only one @entity0 died (16.66%) out of the @entity0 of the second group including @entity0 with acute complicated cholecystopancreatitis (n = 6). The authors think that treatment of acute @entity1 at its onset should be mainly conservative. Laparotomy should be resorted to only in cases of uncertain diagnosis. Surgery or percutaneous drainage should be used in @entity1 and the most favorable term of operation is 2-3 weeks after the disease onset. Severe @entity1 associated with @entity2 and its complications require emergency surgery.

title: Surgical treatment of XXXX and complicated forms of cholecystopancreatitis.

answer: @entity1


abstract: AIM: Nonadherent individuals are the most likely to avoid participating in research studies, thus limiting potential opportunities to develop evidence-based approaches for adherence enhancement. This mixed-method analysis evaluated factors related to adherence among 20 poorly adherent community mental health clinic @entity0 with @entity1 ( @entity1 ). METHODS: Illness experience was evaluated with qualitative interview. Quantitative assessments measured symptoms (Hamilton Depression Rating Scale, Young Mania Rating Scale, Brief Psychiatric Rating Scale), adherence behavior, and treatment attitudes. Poor adherence was defined as missing 30% or more of medication. RESULTS: Minorities (80%), unmarried individuals (95%), and those with @entity2 (65%) predominated in this nonadherent group of @entity0 with @entity1 . Individuals were substantially depressed (mean Hamilton Depression Rating Scale, 19.2), had at least some @entity1 (mean Young Mania Rating Scale, 13.6), and had moderate psychopathology (mean Brief Psychiatric Rating Scale, 41.2). Rates of missed medications were 41% to 43%. Forgetting to take medications was the top reason for nonadherence (55%), followed by side effects (20%). Disorganized home environments (30%), concern regarding having to take long-term medications (25%) or fear of side effects (25%), and insufficient information regarding @entity1 (35%) were relatively common. Almost one third of @entity0 had individuals in their core social network who specifically advised against medication. Access problems included difficulty paying for medications among more than half of @entity0 . Interestingly, @entity0 reported good relationships with their providers. CONCLUSIONS: Forgetting to take medication and problems with side effects are primary drivers of nonadherence. Lack of medication routines, unsupportive social networks, @entity3 , and treatment access problems may likewise affect overall adherence. Complementary quantitative and qualitative data collection can identify reasons for nonadherence and may inform specific clinical approaches to enhance adherence.

title: Illness experience and reasons for nonadherence among individuals with XXXX who are poorly adherent with medication.

answer: @entity1


abstract: An entomological study was conducted in a village of Sudano-Guinean savanna in Senegal, during the rainy season from July to November 2001, to investigate the biology and the involvement of each anopheline species in @entity1 transmission. Mosquitoes were captured when landing on @entity0 volunteers and by pyrethrum spray catches. Twelve anopheline species were captured. Four species amounted to 97% of @entity0 -bait sampling: @entity2 molecular form S, An. arabiensis, An. funestus, and An. nili s.s. All An. gambiae and An. nili females were fed on @entity0 , whereas the anthropophilic rate was 94.5% for An. funestus and 88.9% for An. arabiensis. @entity3 was the only @entity1 parasite found, and infecting only An. gambiae, An. arabiensis, An. funestus, and An. nili. The circumsporozoite rate was 4.5% for An. gambiae, 1.6% for An. arabiensis, 3.9% for An. funestus, and 2.1% for An. nili. During the period of study, the entomological inoculation rate was estimated to 264 infected bites. An. gambiae, An. arabiensis, An. funestus, and An. nili were responsible respectively of 56, 3, 20, and 21% of @entity1 transmission. This study shows for the first time the implication of An. nili in @entity1 transmission in this area and the complexity of the @entity1 vectorial system that should be taken into account for any @entity1 control strategy.

title: Bionomics of @entity2 Giles, An. arabiensis Patton, An. funestus Giles and An. nili (Theobald) (Diptera: Culicidae) and transmission of XXXX in a Sudano-Guinean zone (Ngari, Senegal).

answer: @entity3


abstract: An entomological study was conducted in a village of Sudano-Guinean savanna in Senegal, during the rainy season from July to November 2001, to investigate the biology and the involvement of each anopheline species in @entity1 transmission. Mosquitoes were captured when landing on @entity0 volunteers and by pyrethrum spray catches. Twelve anopheline species were captured. Four species amounted to 97% of @entity0 -bait sampling: @entity2 molecular form S, An. arabiensis, An. funestus, and An. nili s.s. All An. gambiae and An. nili females were fed on @entity0 , whereas the anthropophilic rate was 94.5% for An. funestus and 88.9% for An. arabiensis. @entity3 was the only @entity1 parasite found, and infecting only An. gambiae, An. arabiensis, An. funestus, and An. nili. The circumsporozoite rate was 4.5% for An. gambiae, 1.6% for An. arabiensis, 3.9% for An. funestus, and 2.1% for An. nili. During the period of study, the entomological inoculation rate was estimated to 264 infected bites. An. gambiae, An. arabiensis, An. funestus, and An. nili were responsible respectively of 56, 3, 20, and 21% of @entity1 transmission. This study shows for the first time the implication of An. nili in @entity1 transmission in this area and the complexity of the @entity1 vectorial system that should be taken into account for any @entity1 control strategy.

title: Bionomics of XXXX Giles, An. arabiensis Patton, An. funestus Giles and An. nili (Theobald) (Diptera: Culicidae) and transmission of @entity3 in a Sudano-Guinean zone (Ngari, Senegal).

answer: @entity2


abstract: BACKGROUND/PURPOSE: It has been shown that herbs that contain @entity5 induce @entity0 . Chinese herbalists have easy access to such herbs. Our previous mortality study has shown a significantly increased risk of @entity0 in female but not male herbalists. To re-examine this risk in male herbalists, the incidence of @entity0 was analyzed. METHODS: We enrolled all 6550 Chinese herbalists in Taiwan registered during 1985-2000, and we retrospectively followed the development of @entity0 until 2001 by analysis of data collected from the Taiwan Cancer Registry. Standardized incidence ratios (SIRs) were calculated for @entity0 in herbalists and compared with those for the general population in Taiwan. RESULTS: There were 30 newly diagnosed cases of @entity0 and most of them were transitional cell @entity2 (93.1%). The mean age at diagnosis for @entity2 was 51.6 years, and 51.9% were in the upper urinary tract. After adjustment for age and sex, the SIR for all @entity0 was 3.51 [(95% confidence interval (CI): 2.37-5.01]. When stratified by location, the @entity3 and @entity1 were 4.24 (95% CI: 2.47-6.80) and 2.86 (95% CI: 1.52-4.89), respectively. When analyzed by sex, the SIRs for all @entity0 , @entity3 , and @entity1 were also significantly increased in male herbalists. CONCLUSION: The significant risk of @entity2 noted in male herbalists increases our suspicion that this is an @entity4 that renders regular health assessment of herbalists an urgent necessity.

title: Increased risks of upper tract XXXX in male and female chinese herbalists.

answer: @entity2


abstract: Dysfunction of the frontal lobe is considered to be central to the pathology of @entity2 . However, the nature of these abnormalities is unclear, in particular whether they are affected by treatment. In an earlier functional MRI study of our group we found dorsolateral prefrontal lobe (DLPFC) dysfunction to be present in medication-naive first-episode @entity0 . In this follow-up study, we investigated whether treatment with atypical antipsychotics had an effect on DLPFC functioning, and whether (change in) DLPFC functioning was related to treatment response. Twenty-three medication-naive, first-episode male @entity2 @entity0 and 33 matched healthy controls were scanned at baseline and were re-scanned after 10 weeks, while performing a modified Sternberg working-memory task. We specifically investigated the effect of practice on brain activation, defined as the signal change between a novel and practiced working-memory task. After the baseline scan, @entity0 were treated with atypical antipsychotics. Based on their symptom change after ten weeks, @entity0 were divided into responders and non-responders We found DLPFC function did not change after 10 weeks in healthy controls or in @entity0 who received treatment. However, while @entity0 who responded to treatment did not differ from controls, non-responders showed a reduced practice effect in the DLPFC that was present already at baseline, which did not change after treatment. A reduced practice effect in the DLFPC at baseline was found to be predictive of poor treatment response at 10 weeks. These results suggest that prefrontal @entity1 reflects a distinct neuropathological substrate in a subgroup of treatment non-responsive @entity2 @entity0 .

title: @entity1 predicts treatment response in medication-naive first-episode XXXX .

answer: @entity2


abstract: Dysfunction of the frontal lobe is considered to be central to the pathology of @entity2 . However, the nature of these abnormalities is unclear, in particular whether they are affected by treatment. In an earlier functional MRI study of our group we found dorsolateral prefrontal lobe (DLPFC) dysfunction to be present in medication-naive first-episode @entity0 . In this follow-up study, we investigated whether treatment with atypical antipsychotics had an effect on DLPFC functioning, and whether (change in) DLPFC functioning was related to treatment response. Twenty-three medication-naive, first-episode male @entity2 @entity0 and 33 matched healthy controls were scanned at baseline and were re-scanned after 10 weeks, while performing a modified Sternberg working-memory task. We specifically investigated the effect of practice on brain activation, defined as the signal change between a novel and practiced working-memory task. After the baseline scan, @entity0 were treated with atypical antipsychotics. Based on their symptom change after ten weeks, @entity0 were divided into responders and non-responders We found DLPFC function did not change after 10 weeks in healthy controls or in @entity0 who received treatment. However, while @entity0 who responded to treatment did not differ from controls, non-responders showed a reduced practice effect in the DLPFC that was present already at baseline, which did not change after treatment. A reduced practice effect in the DLFPC at baseline was found to be predictive of poor treatment response at 10 weeks. These results suggest that prefrontal @entity1 reflects a distinct neuropathological substrate in a subgroup of treatment non-responsive @entity2 @entity0 .

title: XXXX predicts treatment response in medication-naive first-episode @entity2 .

answer: @entity1


abstract: BACKGROUND: @entity2 is the sixth most common @entity1 among @entity0 and the leading cause of @entity4 in @entity0 with @entity1 . Opinions differ regarding the role of ultra-radical (extensive) cytoreductive surgery in @entity2 treatment.   OBJECTIVES: To evaluate the effectiveness and morbidity associated with ultra-radical/extensive surgery in the management of @entity2 . SEARCH STRATEGY: We searched the Cochrane Gynaecological Cancer Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2010, Issue 4), MEDLINE and EMBASE (up to November 2010). We also searched registers of clinical trials, abstracts of scientific meetings, reference lists of included studies and contacted experts in the field. SELECTION CRITERIA: Randomised controlled trials (RCTs) or non-randomised studies, analysed using multivariate methods, that compared ultra-radical/extensive and standard surgery in adult @entity0 with advanced primary @entity2 . DATA COLLECTION AND ANALYSIS: Two review authors independently assessed whether potentially relevant studies met the inclusion criteria, abstracted data and assessed the risk of bias. One non-randomised study was identified so no meta-analyses were performed. MAIN RESULTS: One non-randomised study met our inclusion criteria. It analysed retrospective data for 194 @entity0 with stage IIIC advanced @entity2 who underwent either ultra-radical (extensive) or standard surgery and reported disease specific overall survival and perioperative mortality. Multivariate analysis, adjusted for prognostic factors, identified better disease specific survival among @entity0 receiving ultra-radical surgery, although this was not statistically significant (Hazard ratio (HR) = 0.64, 95% confidence interval (CI): 0.40 to 1.04). In a subset of 144 @entity0 with @entity3 , those who underwent ultra-radical surgery had significantly better disease specific survival than @entity0 who underwent standard surgery (adjusted HR = 0.64, 95% CI 0.41 to 0.98). Progression-free survival and quality of life (QoL) were not reported and adverse events were incompletely documented. The study was at high risk of bias. AUTHORS' CONCLUSIONS: We found only low quality evidence comparing ultra-radical and standard surgery in @entity0 with advanced @entity2 and @entity3 . The evidence suggested that ultra-radical surgery may result in better survival.   It was unclear whether there were any differences in progression-free survival, QoL and morbidity between the two groups. The cost-effectiveness of this intervention has not been investigated. We are, therefore, unable to reach definite conclusions about the relative benefits and adverse effects of the two types of surgery.In order to determine the role of ultra-radical surgery in the management of @entity2 , a sufficiently powered randomised controlled trial comparing ultra-radical and standard surgery or well-designed non-randomised studies would be required.

title: Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced XXXX .

answer: @entity2


abstract: The normal tissue tolerance levels to fractionated radiotherapy have been appreciated by a century of careful clinical observations and radiobiological studies in animals. During clinical fractionated radiotherapy, these normal tissue tolerance levels are respected, and severe sequelae of radiotherapy are avoided in the majority of @entity0 . Notwithstanding, a minority of @entity0 experience unexpectedly severe normal tissue reactions. The ability to predict which @entity0 might form this minority would be important. We have conducted a study to develop a rapid and reliable diagnostic test to predict excessive normal tissue @entity2 (NTT) in radiotherapy @entity0 . A flow cytometric immunocytochemical assay was used to measure DNA damage in peripheral blood lymphocytes (PBL) from @entity1 @entity0 exposed to 2-Gy gamma radiation. DNA damage and repair was measured by induction of cellular y- @entity3 in unirradiated and exposed cells at specific time points following exposure. In 12 @entity1 @entity0 that experienced severe @entity2 following radiotherapy, there was a failure to repair DNA double-strand breaks (DSB) as measured by y- @entity3 induction and persistence. In ten @entity1 @entity0 that experienced little or no NTT and in seven normal (noncancer controls), efficient repair of DNA DSB was observed in the y- @entity3 assay. We conclude that a flow cytometric assay based on y- @entity3 induction in PBL of radiotherapy @entity0 may represent a robust, rapid and reliable biomarker to predict NTT during radiotherapy. Further research is required with a larger @entity0 cohort to validate this important study.

title: Prolonged expression of the y- @entity3 DNA repair biomarker correlates with excess acute and chronic XXXX from radiotherapy treatment.

answer: @entity2


abstract: The normal tissue tolerance levels to fractionated radiotherapy have been appreciated by a century of careful clinical observations and radiobiological studies in animals. During clinical fractionated radiotherapy, these normal tissue tolerance levels are respected, and severe sequelae of radiotherapy are avoided in the majority of @entity0 . Notwithstanding, a minority of @entity0 experience unexpectedly severe normal tissue reactions. The ability to predict which @entity0 might form this minority would be important. We have conducted a study to develop a rapid and reliable diagnostic test to predict excessive normal tissue @entity2 (NTT) in radiotherapy @entity0 . A flow cytometric immunocytochemical assay was used to measure DNA damage in peripheral blood lymphocytes (PBL) from @entity1 @entity0 exposed to 2-Gy gamma radiation. DNA damage and repair was measured by induction of cellular y- @entity3 in unirradiated and exposed cells at specific time points following exposure. In 12 @entity1 @entity0 that experienced severe @entity2 following radiotherapy, there was a failure to repair DNA double-strand breaks (DSB) as measured by y- @entity3 induction and persistence. In ten @entity1 @entity0 that experienced little or no NTT and in seven normal (noncancer controls), efficient repair of DNA DSB was observed in the y- @entity3 assay. We conclude that a flow cytometric assay based on y- @entity3 induction in PBL of radiotherapy @entity0 may represent a robust, rapid and reliable biomarker to predict NTT during radiotherapy. Further research is required with a larger @entity0 cohort to validate this important study.

title: Prolonged expression of the y- XXXX DNA repair biomarker correlates with excess acute and chronic @entity2 from radiotherapy treatment.

answer: @entity3


abstract: BACKGROUND: @entity4 in situ of the breast (DCIS) represents a challenge in mammographic screening due to its unknown progression into @entity2 . The majority of the DCIS is detected due to signs of @entity5 on the mammograms. PURPOSE: To analyze the combinations of mammographic morphology and distribution of @entity5 by Van Nuys nuclear grade (grade). MATERIAL AND METHODS: A total of 217 DCIS diagnosed in @entity1 aged 50-69 years old who participated in the Norwegian @entity0 Screening Program in the period November 1995 to December 2007 were reviewed by four breast imaging specialists. The mammograms were classified according to the morphology and distribution of the @entity5 , using BI-RADS nomenclature. Chi square test was used to compare the groups of morphology and distribution by grade. RESULTS: Calcifications were identified in 93% (202/217) of the cases, 15% (30/202) as grade 1 and 74% (149/202) as grade 3. Fine @entity5 were seen in 38% (77/202) of the lesions and fine linear and fine linear branching in 31% (62/202). Sixty-nine percent (53/77) of the fine pleomorphic and 84% (52/62) of the fine linear and fine linear branching @entity5 were high grade lesions. Grouped distribution was seen in about half of all the cases (104/202). Among the high grade lesions with fine @entity3 , 75% (40/53) and 69% (36/52), respectively, had grouped or segmental distribution. CONCLUSION: DCIS presented overlapping groups of morphology and distribution of calcification by grade, but fine @entity3 with grouped and segmental distributions were associated with high grade DCIS. Seeking for further knowledge that allows separation of non-high grade from high grade DCIS has to continue to improve the quality of mammographic screening.

title: Mammographic morphology and distribution of XXXX in situ diagnosed in organized screening.

answer: @entity4


abstract: The influence of @entity2 ( @entity2 ) of @entity1 and @entity0 ( @entity0 ) of the diet on digestive and performance traits of broilers to 21 d was studied. There were four treatments arranged factorially with two @entity1 -processing treatments (raw or heated), two levels of @entity0 (0 or 500 ppm), and five replicates per treatment. Chicks fed @entity2 @entity1 grew faster than broilers fed raw @entity1 until 8 d of age, but the effect disappeared thereafter. In general, @entity0 improved broiler performance at all ages. Intestinal viscosity was increased by @entity2 of @entity1 (P < or = 0.05) and reduced by @entity0 (P < or = 0.001), and the decrease in viscosity caused by @entity0 was greater for @entity2 than for raw @entity1 diets ( @entity2 x @entity0 ; P < or = 0.05). Heat processing of @entity1 and @entity0 of the diet improved apparent retention of nutrients (P < or = 0.001). Age affected apparent retention of nutrients differently. For starch and neutral detergent fiber, retention increased linearly with age (P < or = 0.01), but for the remaining nutrients the retention decreased from d 4 to 8 and then increased until d 21 (P < or = 0.001). Also, the beneficial effects of @entity2 on retention of nutrients were more pronounced at younger ages ( @entity2 x age; P < or = 0.05). Both @entity2 (P < or = 0.001) and @entity0 (P < or = 0.01) increased liver weight, and enzymes reduced the weights of pancreas (P < or = 0.05) and small intestine (P < or = 0.001). Villus height was improved by @entity2 (P < or = 0.001) and @entity0 (P < or = 0.01), but villus surface area was only improved by enzymes (P < or = 0.01). It was concluded that broiler performance is improved by @entity2 of @entity1 at early ages and by @entity0 of the diet throughout the trial. Also, @entity2 and @entity0 increased apparent retention of nutrients, AMEn of the diet, and villus height.

title: Heat processing of XXXX and @entity0 of diets for broilers.

answer: @entity1


abstract: The influence of @entity2 ( @entity2 ) of @entity1 and @entity0 ( @entity0 ) of the diet on digestive and performance traits of broilers to 21 d was studied. There were four treatments arranged factorially with two @entity1 -processing treatments (raw or heated), two levels of @entity0 (0 or 500 ppm), and five replicates per treatment. Chicks fed @entity2 @entity1 grew faster than broilers fed raw @entity1 until 8 d of age, but the effect disappeared thereafter. In general, @entity0 improved broiler performance at all ages. Intestinal viscosity was increased by @entity2 of @entity1 (P < or = 0.05) and reduced by @entity0 (P < or = 0.001), and the decrease in viscosity caused by @entity0 was greater for @entity2 than for raw @entity1 diets ( @entity2 x @entity0 ; P < or = 0.05). Heat processing of @entity1 and @entity0 of the diet improved apparent retention of nutrients (P < or = 0.001). Age affected apparent retention of nutrients differently. For starch and neutral detergent fiber, retention increased linearly with age (P < or = 0.01), but for the remaining nutrients the retention decreased from d 4 to 8 and then increased until d 21 (P < or = 0.001). Also, the beneficial effects of @entity2 on retention of nutrients were more pronounced at younger ages ( @entity2 x age; P < or = 0.05). Both @entity2 (P < or = 0.001) and @entity0 (P < or = 0.01) increased liver weight, and enzymes reduced the weights of pancreas (P < or = 0.05) and small intestine (P < or = 0.001). Villus height was improved by @entity2 (P < or = 0.001) and @entity0 (P < or = 0.01), but villus surface area was only improved by enzymes (P < or = 0.01). It was concluded that broiler performance is improved by @entity2 of @entity1 at early ages and by @entity0 of the diet throughout the trial. Also, @entity2 and @entity0 increased apparent retention of nutrients, AMEn of the diet, and villus height.

title: Heat processing of @entity1 and XXXX of diets for broilers.

answer: @entity0


abstract: PURPOSE: We assessed surgical outcomes for @entity0 intolerant of catheters with secondary progressive @entity2 undergoing urinary diversion/reconstruction for refractory urinary symptoms. MATERIALS AND METHODS: @entity0 with secondary progressive @entity2 treated with ileovesicostomy, enterocystoplasty and ileal loop surgeries were reviewed for demographic, operative and postoperative data. All @entity0 had attempted maximal conservative therapy, including catheterization options. Evaluated outcome measures included incidence of postoperative @entity6 , @entity5 and Clavien grade 3 or higher complications. RESULTS: A total of 26 @entity0 (22 female) with secondary progressive @entity2 underwent 15 ileovesicostomy, 7 enterocystoplasty and 4 ileal loop procedures. All @entity0 had significant @entity3 (mean Expanded Disability Status Scale 7), and the most common indications for surgery were chronic @entity5 (77%) and refractory @entity6 (77%). Maximum preoperative bladder capacity was 185 cc and mean bladder compliance was 5.7 cc/cm @entity7 . After a mean followup of 16 months 63% of @entity0 were continent (p = 0.01) and 58% had no further @entity5 (p = 0.03). The type of diversion/reconstruction was not associated with significantly improved continence or @entity5 reduction. No new upper tract changes developed in any @entity0 . There were 11 high grade complications, and @entity0 with a preoperative indwelling catheter (HR 5.89, p = 0.024), @entity1 (HR 5.60, p = 0.009) and increasing @entity4 during surgery (HR 1.09, p = 0.014) were at greatest risk for significant complications. CONCLUSIONS: @entity0 with secondary progressive @entity2 treated with urinary diversion/reconstruction who cannot tolerate catheters had improved continence and fewer @entity5 . However, @entity0 with secondary progressive @entity2 with preoperative indwelling catheters, @entity1 , increased body mass index and increasing operative @entity4 were at greatest risk for postoperative morbidity.

title: Urinary diversion/reconstruction for cases of catheter intolerant secondary progressive XXXX with refractory urinary symptoms.

answer: @entity2


abstract: @entity10 (lipoid CAH) is the most severe form of CAH in which the synthesis of all gonadal and adrenal cortical @entity1 is markedly impaired. Lipoid CAH may be caused by the defect in either the @entity2 ( @entity2 ) protein or the @entity8 . More than 34 different mutations in @entity2 gene have been identified. Clinically, most of the @entity0 manifest @entity5 from 1 day to 2 months of age, but some @entity0 show delayed onset of @entity5 . Affected 46, XY subjects do not show pubertal development, whereas affected 46, XX subjects undergo spontaneous feminization, breast development and cyclical @entity7 at the usual age of puberty. X-linked @entity3 ( @entity3 ) is a rare @entity3 characterized by severe @entity5 and @entity9 . More than 80 different several intragenic mutations of @entity6 have been identified. The failure of pubertal development may be caused by either @entity4 or pituitary regulation of gonadotropin secretion. In addition, although the testicular steroidogenesis is largely intact, the functional maturity of Sertoli cells and also spermatogenesis are impaired. The type of mutation does not predict clinical phenotype. Thus, unified mechanism how @entity6 gene defect gives rise to @entity5 , @entity4 /pituitary @entity9 and impaired spermatogenesis remains established.

title: Molecular pathogenesis of XXXX and adrenal hypoplasia congenita.

answer: @entity10


abstract: The release of spectrin-free vesicles from @entity1 -depleted @entity0 red blood cells (Lutz et al. (1977) J. Cell. Biol. 73, 548) can be considered the final step of a shape change from discocytes to echinocytes. The study of physical and chemical properties of released vesicles suggests that vesicle release is not merely a consequence of charge alterations within either monolayer of the budding membrane. Fresh membranes and released vesicles have within experimental error the same @entity4 content per surface area and the same electrophoretic mobilities. Vesicle release cannot be stimulated by doubling the charge density on the outer monolayer by means of a phospholipase D-treatment, but correlates with a breakdown of @entity6 to @entity3 on the inner monolayer. This breakdown does not lead to a significant change in the negative charge density on the inner monolayer, because an increased @entity5 content compensates for this alteration. Furthermore, @entity6 breakdown and @entity3 production are not the rate-limiting step in vesicle release from @entity1 -depleting red blood cells. This is evident from the fact that 10 mM @entity2 inhibits vesicle release to 75% without affecting @entity6 breakdown and @entity3 production. Hence, @entity3 formation may be sufficient for membrane budding as suggested earlier (Allan et al. (1976) Nature 261, 58), but vesicle release requires a second, as yet unidentified process.

title: On the mechanism of vesicle release from XXXX -depleted @entity0 red blood cells.

answer: @entity1


abstract: The release of spectrin-free vesicles from @entity1 -depleted @entity0 red blood cells (Lutz et al. (1977) J. Cell. Biol. 73, 548) can be considered the final step of a shape change from discocytes to echinocytes. The study of physical and chemical properties of released vesicles suggests that vesicle release is not merely a consequence of charge alterations within either monolayer of the budding membrane. Fresh membranes and released vesicles have within experimental error the same @entity4 content per surface area and the same electrophoretic mobilities. Vesicle release cannot be stimulated by doubling the charge density on the outer monolayer by means of a phospholipase D-treatment, but correlates with a breakdown of @entity6 to @entity3 on the inner monolayer. This breakdown does not lead to a significant change in the negative charge density on the inner monolayer, because an increased @entity5 content compensates for this alteration. Furthermore, @entity6 breakdown and @entity3 production are not the rate-limiting step in vesicle release from @entity1 -depleting red blood cells. This is evident from the fact that 10 mM @entity2 inhibits vesicle release to 75% without affecting @entity6 breakdown and @entity3 production. Hence, @entity3 formation may be sufficient for membrane budding as suggested earlier (Allan et al. (1976) Nature 261, 58), but vesicle release requires a second, as yet unidentified process.

title: On the mechanism of vesicle release from @entity1 -depleted XXXX red blood cells.

answer: @entity0


abstract: Environmental equity has been identified as a challenge and goal of national to global air quality management. Here, relationships between traffic-related air pollution measures and the social demographics of elementary schools are investigated. Ogawa passive samplers were used to measure ambient @entity3 ( @entity2 ) levels near 75 randomly selected elementary schools in the county containing Tampa, FL over one week in March 2008. Concentrations were determined using colorimetric reaction using Hach @entity1 reagent and photometric detection at 545 nm. @entity2 levels, two metrics of traffic (highest annual average daily traffic count within 500 m and 1000 m), and school enrollment data by demographic subgroup (racial/ethnic and socioeconomic) were then compared. Data were analyzed for distribution statistics, linear correlations, and differences in subgroup category means. Weighted average values of @entity2 and traffic count were also calculated for each subgroup. All measured @entity2 levels were low, with a mean of 2.7 ppbv and range from 0.8 to 4.7 ppbv. Values were largest at sites near downtown. Results from all analyses show comparatively higher potential exposures to measured @entity2 and traffic count for black school @entity0 , and lower values for white and Asian or Pacific Islander school @entity0 . The economically disadvantaged and Hispanic subgroups were also associated with higher levels of @entity2 and traffic counts, but the relationship was not as strong or robust. Although measured @entity2 levels were low and the differences between groups are small, results suggest disparities by racial/ethnic and economic status in @entity0 's exposures to air pollution for the Tampa area.

title: An inequality study of ambient XXXX and traffic levels near elementary schools in the Tampa area.

answer: @entity3


abstract: PURPOSE: To prospectively evaluate the primary and long-term venographic and clinical results of catheter-directed thrombolysis in the treatment of proximal @entity2 ( @entity2 ) of lower extremity. MATERIALS AND METHODS: Fifty-six @entity0 with mean age of 48 (range 15-81) years with acute @entity2 (symptom duration of less than 2 weeks), extending to high femoral (16 @entity0 ) or iliac vein (40 @entity0 ) were treated with selective catheter-directed thrombolysis. The mean total dose of 3.8 (range 1.0-8.1) million units of urokinase was administered during a mean of 39 (range 6-72) hours. Endovascular stenting was performed in 9 of the iliac @entity2 @entity0 . RESULTS: Complete procedural venographic success was achieved in 79% of @entity0 . Major complications were noted in 7% of @entity0 and the total rate of complications was 13%. Mean venographic follow-up was 3.5 years (range 3 months to 9.6 years); well preserved femoral vein valves and fully recanalized deep crural veins were observed in 83% and 57% of @entity0 . Normal clinical findings in the affected limb were noted during the latest follow-up visit in 67% of @entity0 . Clinical @entity1 occurred in 9% of @entity0 . CONCLUSION: Catheter-directed thrombolysis achieves good primary success with acceptable complication rate and effectively reduces prevalence of @entity1 .

title: Catheter-directed thrombolysis of proximal lower extremity XXXX : a prospective trial with venographic and clinical follow-up.

answer: @entity2


abstract: Kindling is a widely used animal model of intractable @entity4 . In the present study, we performed fast Fourier transformation (FFT) analysis of kindling-induced afterdischarge (AD) in the @entity1 hippocampus. Ten adult @entity1 were used. Kindling stimulation to the right hippocampus was delivered as a train of biphasic pulses (1 ms duration each) of 50 Hz for 1s, with suprathreshold intensity for AD. Motor responses were classified into five stages according to the conventional criteria. Of 10 animals, five developed stage 5 @entity3 with a mean of 21 stimulations (kindled (K) group), while the remaining five animals did not (incomplete kindling (IK) group). We standardized each ratio of power spectral density of lower frequency band component (LFB: 0-9 Hz) and the higher frequency band (HFB: 12-30 Hz) in the initial stage as 1.0. The IK group exhibited small decrements (0.99 and 0.94 times) in LFB and HFB components at the final stage. In contrast, the K group exhibited a significantly (p<0.05) large decrement (0.49 times) in the LFB component and a very large increment (4.45 times) of HFB component at the final stage. Correlation analyses were performed between alteration of power spectral density ratio of the HFB component and AD duration, interictal discharge frequency, and behavioral stage during kindling progression. Fairly strong positive correlations were found in all cases in the K group. FFT analysis of kindling-induced AD demonstrated an important role of the HFB component: enhancement of the HFB component is associated with kindled stage, while decrement of it is associated with @entity0 . These findings suggest that FFT analysis of stimulus-induced and spontaneous @entity3 discharges is useful for examination of the progression of @entity2 .

title: Fast Fourier transformation analysis of kindling-induced afterdischarge in the XXXX hippocampus.

answer: @entity1


abstract: STUDY OBJECTIVE: Evaluation of active deflection flexible miniureterorenoscopes for diagnostic or therapeutic applications in the management of upper @entity3 . MATERIAL AND METHOD: The authors report a series of 111 consecutive @entity0 undergoing a total of 137 flexible ureteroscopies for upper urinary tract disease between November 1997 and April 2001. The procedures were performed for diagnostic purposes (54 cases: 39%) or therapeutic purposes (83 cases; 61%). A successful procedure was defined as achievement of the objective defined when establishing the indication for ureteroscopy. The mean age of the @entity0 was 51 +/- 15 years. The main diseases investigated or treated were stones (66%) and @entity1 (25%). RESULTS: The mean operating time was 42 +/- 22 min. The median length of postoperative hospital stay was 2 days (range: 0-27 days). 8% of @entity0 did not require any postoperative ureteric drainage. 78% of the flexible ureteroscopies performed were successful. Complications were observed in 8% of cases, mainly macroscopic haematuria, including 3 major complications in the form of ureteric perforation. Serious intraoperative equipment damage was observed in 4% of cases. CONCLUSION: Ureteroscopy with a flexible mini-ureteroscope is an effective, reproducible and minimally traumatic diagnostic and therapeutic technique for lesions situated above the iliac vessels. The use of various instruments, including the @entity4 :Yag laser, should increase the range of possibilities of endoscopic techniques. The major limitation of active deflection flexible mini-ureterorenoscopes remains their @entity2 .

title: [Flexible ureteroscopy in upper XXXX ].

answer: @entity3


abstract: BACKGROUND: Magnetic resonance imaging (MRI) is of vital importance in the diagnosis and follow-up of @entity0 with @entity1 ( @entity1 ). Imaging sequences better demonstrating enhancing lesions can help in detecting active @entity1 plaques. PURPOSE: To evaluate the role of fat-saturated @entity2 -enhanced T1-weighted (T1W) images of the brain in @entity1 and to assess the benefit of performing this additional sequence in the detection of enhancing lesions. MATERIAL AND METHODS: In a prospective study over a six-month period, 70 consecutive @entity0 with clinically diagnosed @entity1 were enrolled. These constituted 14 male and 56 female @entity0 between the ages of 21 and 44 years. All the @entity0 underwent brain MRIs on a 1.5 Tesla Magnet. @entity2 -enhanced T1 images with and without fat saturation were compared and results were recorded and analyzed using a conspicuity score and McNemar test. RESULTS: There were a total of 157 lesions detected in 70 @entity0 on post-contrast T1W fat-saturated images compared with 139 lesions seen on the post-contrast T1W fast spin-echo (FSE) images. This was because 18 of the lesions (11.5%) were only seen on the fat-saturated images. In addition, 15 lesions were more conspicuous on the fat saturation sequence (9.5%). The total conspicuity score obtained, including all the lesions, was 2.24 +/-0.60 (SD). Using the two-tailed McNemar test for quantitative analysis, the P value obtained was <0.0001. CONCLUSION: T1W fat-saturated @entity2 -enhanced images show better lesion enhancement than T1W images without fat saturation.

title: Fat-saturated post XXXX T1 imaging of the brain in @entity1 .

answer: @entity2


abstract: BACKGROUND: Magnetic resonance imaging (MRI) is of vital importance in the diagnosis and follow-up of @entity0 with @entity1 ( @entity1 ). Imaging sequences better demonstrating enhancing lesions can help in detecting active @entity1 plaques. PURPOSE: To evaluate the role of fat-saturated @entity2 -enhanced T1-weighted (T1W) images of the brain in @entity1 and to assess the benefit of performing this additional sequence in the detection of enhancing lesions. MATERIAL AND METHODS: In a prospective study over a six-month period, 70 consecutive @entity0 with clinically diagnosed @entity1 were enrolled. These constituted 14 male and 56 female @entity0 between the ages of 21 and 44 years. All the @entity0 underwent brain MRIs on a 1.5 Tesla Magnet. @entity2 -enhanced T1 images with and without fat saturation were compared and results were recorded and analyzed using a conspicuity score and McNemar test. RESULTS: There were a total of 157 lesions detected in 70 @entity0 on post-contrast T1W fat-saturated images compared with 139 lesions seen on the post-contrast T1W fast spin-echo (FSE) images. This was because 18 of the lesions (11.5%) were only seen on the fat-saturated images. In addition, 15 lesions were more conspicuous on the fat saturation sequence (9.5%). The total conspicuity score obtained, including all the lesions, was 2.24 +/-0.60 (SD). Using the two-tailed McNemar test for quantitative analysis, the P value obtained was <0.0001. CONCLUSION: T1W fat-saturated @entity2 -enhanced images show better lesion enhancement than T1W images without fat saturation.

title: Fat-saturated post @entity2 T1 imaging of the brain in XXXX .

answer: @entity1