abstract: BACKGROUND: The literature concerning stricture secondary to @entity5 is poor. Stricture in this setting should be an indication for surgery because (a) of the potential risk of @entity1 and (b) morbidity is not increased compared to other indications for colectomy. The goal of this report is to study the post-surgical morbidity and the quality of life in @entity0 after sigmoidectomy for sigmoid stricture associated with @entity2 . METHOD: This is a monocenter retrospective observational study including @entity0 with a preoperative diagnosis of sigmoid stricture associated with @entity2 undergoing operation between Jan 1, 2007 and Dec 31, 2013. The GastroIntestinal Quality of Life Index was used to assess @entity0 satisfaction. RESULTS: Sixteen @entity0 were included of which nine were female. Median age was 69.5 (46-84) and the median body mass index was 23.55kg/m(2) (17.2-28.4). Elective sigmoidectomy was performed in all 16 @entity0 . Overall, complications occurred in five @entity0 (31.2%) (4 minor complications and 1 major complication according to the Dindo and Clavien Classification); none resulted in @entity3 . Pathology identified two @entity4 (12.5%). The mean GastroIntestinal Quality of Life Index was 122 (67-144) and 10/11 @entity0 were satisfied with their surgical intervention. CONCLUSION: Sigmoid stricture prevents endoscopic exploration of the entire colon and thus it may prove difficult to rule out a @entity1 . Surgery does not impair the quality of life since morbidity is similar to other indications for sigmoidectomy. For these reasons, we recommend that stricture associated with @entity2 should be an indication for sigmoidectomy including lymph node clearance.

title: Sigmoid stricture associated with XXXX should be an indication for elective surgery with lymph node clearance.

answer: @entity2


abstract: BACKGROUND/AIM: @entity3 ( @entity3 ) is usually an @entity8 with rapid progression in around soft tissue. If not promptly recognized and aggressively treated @entity3 usualy leads to @entity7 and @entity6 with fatal outcome, thus early diagnosis and prompt surgical treatment are crucial for healing of these @entity0 . The aim of this article was to evaluate the clinical presentation of all @entity0 with acute @entity3 diagnosed and treated in surgical clinics of Clinical Center of Vojvodina, Novi Sad, Serbia. METHODS: The medical records of @entity0 treated for acute @entity3 localized on a different parts of the body in Clinical Center of Vojvodina, Novi Sad, Serbia, during a 5-year period (from January 2008 to December 2012) were retrospectively evaluated. This study enrolled @entity0 admitted via Emergency Center of Vojvodina with the diagnosis of acute @entity3 either as the primary diagnosis or with the diagnosis at discharge after surgical treatment. RESULTS: During a 5-year period there were 216 @entity0 with final diagnosis of acute @entity3 . Most of our @entity0 (140-64.81%) were admitted with the initial diagnosis of @entity9 , abscesses, phlegmons or @entity7 . Unfortunately, the clinical symptoms of acute @entity3 were atypical at time of initial examination. @entity5 and swelling of the affected localization were the most presented bias of symptoms (183-84.72%). The majority of our @entity0 were male (164-75.92%). Among the 216 @entity0 , the most common pre-existing single factor was drug abuse (39-18.05%), followed by @entity2 (38-17.59%) and @entity1 (31-14.35%). @entity4 was most common etiological factor (22-10.8%) in infected wounds, followed by abdominal (15-6.94%) and orthopedic (11-5.09%) surgical intervention. In the present study idiopathic acute @entity3 was diagnosed in 22 (10.18%) @entity0 and more than one etiological factor were diagnosed in 20 (9.25%) @entity0 . The majority of our pa- tients had type I acute @entity3 (172-79.62%) with Streptococcal species as the most common microorganism (125-71.02%). The most common localization was an extremity (151-69.90%). The minority of our @entity0 had head and neck lo- calization of infection (7-3.24%). Surgical treatment was performed in all the @entity0 and most of them (183-84.72%) received the first surgery within 24 h. Other @entity0 (23-10.64%) received operation after stabilization of general status or after getting the diagnosis of acute @entity3 (unclear diagnosis on admission). During hospitalization, the most common complication among our @entity0 was @entity7 (156-72.22%). The mortality rate was 14.35%. CONCLUSION: Acute @entity3 is a rare but very difficult and sometimes life-threatening disease of superficial fascia and around soft tissue. If acute @entity3 is suspected, early radical excision of all the affected tissue with exploration and excision of superficial fascia with pathological and microbiological assessment are most significant for treatment. Appropriate antibiotics and intensive care set ting to manage other organ failure of @entity3 are recommended at the same time with surgery.

title: A 5-year retrospective analysis of XXXX --a single center experiences.

answer: @entity3


abstract: 1. Polymorphonuclear neutrophils are involved in the development of @entity3 during ischaemia through the release of free @entity1 radicals and by adhesion of activated polymorphonuclear neutrophils to endothelium, resulting in plugging of coronary capillaries. Polymorphonuclear neutrophil activation may be a result of contact with ligands expressed by endothelial cells and/or a response to soluble stimuli released from ischaemic tissue to the plasma. 2. To investigate this we studied plasma-mediated polymorphonuclear neutrophil activation in vitro using plasma samples collected from 14 @entity0 with @entity4 at time of admission and 6 h and 1, 2, 5 and 7 days later. Plasma samples were incubated with washed polymorphonuclear neutrophils isolated from healthy donors. Expression of adhesion molecules @entity6 / @entity8 integrin and @entity5 ( @entity5 ) were measured by flow cytometry and @entity2 anion production in polymorphonuclear neutrophils was measured by chemiluminescence. 3. Plasma samples obtained 6 h and 1 day after admission were capable of inducing @entity6 / @entity8 antigen expression, @entity2 anion production and @entity5 shedding in the washed polymorphonuclear neutrophils, and this effect was significant when compared with plasma taken at 5 and 7 days after admission. 4. The plasma-mediated polymorphonuclear neutrophil stimulation was prevented when the PMN were pretreated with platelet-activating factor receptor antagonists @entity7 or @entity9 . The platelet-activating factor concentrations detected in the plasma samples were not higher than those detected in plasma from healthy subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Plasma-mediated neutrophil activation during XXXX : role of platelet-activating factor.

answer: @entity4


abstract: In this paper we determine whether individual and family psychosocial functioning predicts the risk for recurrent acute @entity1 complications. An onset-cohort of 61 @entity0 and adolescents with Type 1 @entity1 received conventional @entity1 care. Episodes of @entity2 and of severe @entity3 were recorded for 8 years, and glycaemic control was measured by glycohaemoglobin. Measures of psychosocial functioning of the @entity0 and parents were obtained during the first year. Over 8 years, 28% of subjects had at least one episode of @entity2 , and 21% had at least one episode of hypoglycaemia. The odds of observing recurrent hypoglycaemia versus recurrent @entity2 was 14 times greater in @entity0 than in @entity0 (Fisher's exact test p < 0.05). @entity0 with recurrent @entity2 had more behaviour problems and lower social competence, they reported higher levels of family conflict, and their parents reported lower levels of family cohesion, expressiveness and organization in year one. These relationships were independent of any association with poor glycaemic control. Recurrent hypoglycaemia in @entity0 was generally unrelated to individual and family functioning or glycohaemoglobin. Despite our small sample size, our findings are suggestive of relationships that may lead to early identification of @entity0 who are prone to recurrent @entity2 , and to the development of early intervention strategies.

title: Psychosocial predictors of acute complications of XXXX in youth.

answer: @entity1


abstract: Recently, we observed a case of lumbar @entity5 after @entity1 , which was treated by endovascular embolization. A 67-year-old @entity0 who was injured in a traffic accident was brought to the emergency room. She was conscious and her hemodynamic condition was stable, but she had @entity3 below L1 dermatome. Contrast-enhanced computed tomography scan of abdomen and pelvis revealed @entity2 of L3/4 along with retroperitoneal @entity7 . However, there was no evidence of @entity1 in both thoracic and abdominal cavity. At that time, her blood pressure suddenly decreased to 60/40 mmHg and her mental status deteriorated. Also, her hemoglobin level was 5.4 g/dl. While her hemodynamic condition stabilized with massive fluid resuscitation including blood transfusion, an angiography was immediately performed to look for and embolize site of retroperitoneal @entity4 . On the angiographic images, there was an active extravasation from ruptured left 3rd lumbar artery, and we performed complete embolization with GELFOAM and coil. Lumbar @entity5 after @entity1 is rare and endovascular treatment is useful in case of @entity6 .

title: Traumatic lumbar artery rupture after lumbar spinal XXXX causing hypovolemic shock: An endovascular treatment.

answer: @entity2


abstract: @entity2 ( @entity1 ), an s- @entity3 herbicide, is a widespread environmental contaminant. The hepatocarcinogenic component of technical grade @entity7 , @entity4 ( @entity5 , 19.5%), is a byproduct of @entity6 synthesis and is found at production sites. This study explores the effect of @entity1 treatment on the bioactivation of the promutagen, @entity5 . Male Fischer 344 @entity0 (5 weeks old) were administered 50 mg/kg of @entity1 by gavage for 5 weeks. At 1, 3, and 5 weeks, both DMSO-control and @entity1 -pretreated @entity0 were treated p.o. with 75 mg/kg of @entity5 and were housed in metabolism cages for urine collection. Sulfatase- and beta-glucuronidase-treated, concentrated urine was bioassayed for urinary mutagens in a microsuspension modification of the Salmonella assay with and without metabolic activation. No significant change in mutagen excretion was observed in @entity1 -treated @entity0 ; however, an elevation in direct-acting urine mutagens from @entity0 receiving @entity1 and @entity5 at weeks 1 (359 +/- 68 vs. 621 +/- 96 revertants/ml) and 5 (278 +/- 46 vs. 667 +/- 109 revertants/ml) of treatment was observed. The increase in production of urinary mutagens was accompanied by an elevation in small intestinal nitroreductase activity. Increases in large intestinal nitroreductase and beta-glucuronidase were observed after 5 weeks. There was no apparent effect of @entity1 following 5 weeks of treatment on the production of @entity5 -derived hepatic DNA adducts. @entity1 treatment modifies intestinal enzymes responsible for promutagen bioactivation, and potentiates the excretion of mutagenic urine in @entity5 -treated animals.

title: @entity2 treatment potentiates excretion of mutagenic urine in XXXX -treated Fischer 344 @entity0 .

answer: @entity4


abstract: @entity2 ( @entity1 ), an s- @entity3 herbicide, is a widespread environmental contaminant. The hepatocarcinogenic component of technical grade @entity7 , @entity4 ( @entity5 , 19.5%), is a byproduct of @entity6 synthesis and is found at production sites. This study explores the effect of @entity1 treatment on the bioactivation of the promutagen, @entity5 . Male Fischer 344 @entity0 (5 weeks old) were administered 50 mg/kg of @entity1 by gavage for 5 weeks. At 1, 3, and 5 weeks, both DMSO-control and @entity1 -pretreated @entity0 were treated p.o. with 75 mg/kg of @entity5 and were housed in metabolism cages for urine collection. Sulfatase- and beta-glucuronidase-treated, concentrated urine was bioassayed for urinary mutagens in a microsuspension modification of the Salmonella assay with and without metabolic activation. No significant change in mutagen excretion was observed in @entity1 -treated @entity0 ; however, an elevation in direct-acting urine mutagens from @entity0 receiving @entity1 and @entity5 at weeks 1 (359 +/- 68 vs. 621 +/- 96 revertants/ml) and 5 (278 +/- 46 vs. 667 +/- 109 revertants/ml) of treatment was observed. The increase in production of urinary mutagens was accompanied by an elevation in small intestinal nitroreductase activity. Increases in large intestinal nitroreductase and beta-glucuronidase were observed after 5 weeks. There was no apparent effect of @entity1 following 5 weeks of treatment on the production of @entity5 -derived hepatic DNA adducts. @entity1 treatment modifies intestinal enzymes responsible for promutagen bioactivation, and potentiates the excretion of mutagenic urine in @entity5 -treated animals.

title: XXXX treatment potentiates excretion of mutagenic urine in @entity4 -treated Fischer 344 @entity0 .

answer: @entity2


abstract: @entity2 ( @entity1 ), an s- @entity3 herbicide, is a widespread environmental contaminant. The hepatocarcinogenic component of technical grade @entity7 , @entity4 ( @entity5 , 19.5%), is a byproduct of @entity6 synthesis and is found at production sites. This study explores the effect of @entity1 treatment on the bioactivation of the promutagen, @entity5 . Male Fischer 344 @entity0 (5 weeks old) were administered 50 mg/kg of @entity1 by gavage for 5 weeks. At 1, 3, and 5 weeks, both DMSO-control and @entity1 -pretreated @entity0 were treated p.o. with 75 mg/kg of @entity5 and were housed in metabolism cages for urine collection. Sulfatase- and beta-glucuronidase-treated, concentrated urine was bioassayed for urinary mutagens in a microsuspension modification of the Salmonella assay with and without metabolic activation. No significant change in mutagen excretion was observed in @entity1 -treated @entity0 ; however, an elevation in direct-acting urine mutagens from @entity0 receiving @entity1 and @entity5 at weeks 1 (359 +/- 68 vs. 621 +/- 96 revertants/ml) and 5 (278 +/- 46 vs. 667 +/- 109 revertants/ml) of treatment was observed. The increase in production of urinary mutagens was accompanied by an elevation in small intestinal nitroreductase activity. Increases in large intestinal nitroreductase and beta-glucuronidase were observed after 5 weeks. There was no apparent effect of @entity1 following 5 weeks of treatment on the production of @entity5 -derived hepatic DNA adducts. @entity1 treatment modifies intestinal enzymes responsible for promutagen bioactivation, and potentiates the excretion of mutagenic urine in @entity5 -treated animals.

title: @entity2 treatment potentiates excretion of mutagenic urine in @entity4 -treated Fischer 344 XXXX .

answer: @entity0


abstract: BACKGROUND: Targeted PCR-based genetic testing for @entity4 and @entity1 can be performed at a lower cost than full gene testing; however, it does not detect mutations responsible for @entity3 . In the present study, we report the utility of next generation sequencing (NGS) to identify new pathogenic variants of @entity5 . METHODS: @entity4 and @entity1 exons were amplified using the Ion AmpliSeq @entity5 Panel and sequenced on the Ion Torrent PGM sequencer in 512 @entity0 with familial and/or only early onset @entity3 who were negative for selected @entity4 /2 mutations. RESULTS: 146 single @entity2 variants (SNVs) and 32 indels were identified. Of them, 14 SNVs and 17 indels were considered as pathogenic or likely pathogenic. One and 18 pathogenic mutations had been detected previously in the Polish and other populations, respectively, and 12 deleterious mutations were previously unknown. Eight mutations were recurrent; @entity6 ( @entity4 ), N3124I ( @entity1 ) and @entity7 ( @entity4 ) were found in eight, six and four @entity0 , respectively, and two other mutations ( @entity8 and @entity9 in @entity1 ) were detected in three @entity0 each. Altogether, @entity5 pathogenic mutations were identified in 52 out of 512 (10%) @entity0 . CONCLUSIONS: NGS substantially improved the detection rates of a wide spectrum of mutations in Polish @entity0 with @entity3 . Although targeted screening for specific @entity4 mutations can be offered to all Polish @entity3 @entity0 , NGS-based testing is justified in @entity0 with @entity3 likely related to @entity5 who test negative for the selected @entity4 /2 pathogenic mutations.

title: New recurrent @entity5 mutations in Polish @entity0 with XXXX detected by next generation sequencing.

answer: @entity3


abstract: BACKGROUND: Targeted PCR-based genetic testing for @entity4 and @entity1 can be performed at a lower cost than full gene testing; however, it does not detect mutations responsible for @entity3 . In the present study, we report the utility of next generation sequencing (NGS) to identify new pathogenic variants of @entity5 . METHODS: @entity4 and @entity1 exons were amplified using the Ion AmpliSeq @entity5 Panel and sequenced on the Ion Torrent PGM sequencer in 512 @entity0 with familial and/or only early onset @entity3 who were negative for selected @entity4 /2 mutations. RESULTS: 146 single @entity2 variants (SNVs) and 32 indels were identified. Of them, 14 SNVs and 17 indels were considered as pathogenic or likely pathogenic. One and 18 pathogenic mutations had been detected previously in the Polish and other populations, respectively, and 12 deleterious mutations were previously unknown. Eight mutations were recurrent; @entity6 ( @entity4 ), N3124I ( @entity1 ) and @entity7 ( @entity4 ) were found in eight, six and four @entity0 , respectively, and two other mutations ( @entity8 and @entity9 in @entity1 ) were detected in three @entity0 each. Altogether, @entity5 pathogenic mutations were identified in 52 out of 512 (10%) @entity0 . CONCLUSIONS: NGS substantially improved the detection rates of a wide spectrum of mutations in Polish @entity0 with @entity3 . Although targeted screening for specific @entity4 mutations can be offered to all Polish @entity3 @entity0 , NGS-based testing is justified in @entity0 with @entity3 likely related to @entity5 who test negative for the selected @entity4 /2 pathogenic mutations.

title: New recurrent XXXX mutations in Polish @entity0 with @entity3 detected by next generation sequencing.

answer: @entity5


abstract: BACKGROUND: Targeted PCR-based genetic testing for @entity4 and @entity1 can be performed at a lower cost than full gene testing; however, it does not detect mutations responsible for @entity3 . In the present study, we report the utility of next generation sequencing (NGS) to identify new pathogenic variants of @entity5 . METHODS: @entity4 and @entity1 exons were amplified using the Ion AmpliSeq @entity5 Panel and sequenced on the Ion Torrent PGM sequencer in 512 @entity0 with familial and/or only early onset @entity3 who were negative for selected @entity4 /2 mutations. RESULTS: 146 single @entity2 variants (SNVs) and 32 indels were identified. Of them, 14 SNVs and 17 indels were considered as pathogenic or likely pathogenic. One and 18 pathogenic mutations had been detected previously in the Polish and other populations, respectively, and 12 deleterious mutations were previously unknown. Eight mutations were recurrent; @entity6 ( @entity4 ), N3124I ( @entity1 ) and @entity7 ( @entity4 ) were found in eight, six and four @entity0 , respectively, and two other mutations ( @entity8 and @entity9 in @entity1 ) were detected in three @entity0 each. Altogether, @entity5 pathogenic mutations were identified in 52 out of 512 (10%) @entity0 . CONCLUSIONS: NGS substantially improved the detection rates of a wide spectrum of mutations in Polish @entity0 with @entity3 . Although targeted screening for specific @entity4 mutations can be offered to all Polish @entity3 @entity0 , NGS-based testing is justified in @entity0 with @entity3 likely related to @entity5 who test negative for the selected @entity4 /2 pathogenic mutations.

title: New recurrent @entity5 mutations in Polish XXXX with @entity3 detected by next generation sequencing.

answer: @entity0


abstract: OBJECTIVE: There is limited evidence to support decision making on antiplatelet therapy following transcatheter @entity4 (TAVI). Our aim was to assess the efficacy and safety of @entity2 -only (ASA) versus dual antiplatelet therapy (DAPT) following TAVI. METHODS: We performed a systematic review and pooled analysis of individual @entity0 data from 672 @entity0 comparing single versus DAPT following TAVI. Primary endpoint was defined as the composite of net adverse clinical and cerebral events (NACE) at 1   month, including all-cause mortality, @entity5 ( @entity5 ), @entity1 , life-threatening and major @entity3 . RESULTS: At 30   days a NACE rate of 13% was observed in the ASA-only and in 15% of the DAPT group (OR 0.83, 95% CI 0.48 to 1.43, p=0.50). A tendency towards less life-threatening and major @entity3 was observed in @entity0 treated with ASA (OR 0.56, 95% CI 0.28 to 1.11, p=0.09). Also, ASA was not associated with an increased all-cause mortality (OR 0.91, 95% CI 0.36 to 2.27, p=0.83), @entity5 (OR 0.5, 95% CI 0.05 to 5.51, p=0.57) or @entity1 (OR 1.21; 95% CI 0.36 to 4.03, p=0.75). CONCLUSIONS: No difference in 30-day NACE rate was observed between ASA-only or DAPT following TAVI. Moreover, a trend towards less life-threatening and major @entity3 was observed in favour of ASA. Consequently the additive value of @entity6 warrants further investigation.

title: Antiplatelet therapy following transcatheter XXXX .

answer: @entity4


abstract: INTRODUCTION: Stress-induced @entity1 (Takotsubo) after @entity7 stings in @entity0 who have received @entity6 is rare. Endogenous as well as exogenous administration of @entity6 is thought to trigger stress-induced @entity1 . CASE PRESENTATION: A 37-year-old healthy white @entity0 was stung by an unknown Hymenoptera that resulted in an anaphylactic reaction. Intravenous @entity4 (0.9  mg) was administered at a nearby clinic; she was transferred to our emergency room. @entity5 was diagnosed and mechanical ventilation commenced. Hemodynamic stabilization was not achieved by inotropic support and intra-aortic balloon pump insertion. Initial coronary angiography did not demonstrate any @entity2 while her left ventricular systolic function was severely @entity3 . Peripheral femoral venoarterial extracorporeal membrane oxygenation was inserted as a bridge to recovery assuming possible reversible cause of the @entity5 . Over the following 48  hours she was extubated and gradually weaned off venoarterial extracorporeal membrane oxygenation and inotropic support. She was discharged with a near normal left ventricular ejection fraction and in 3  weeks she was asymptomatic with normal electrocardiographic and echocardiographic examinations (left ventricular ejection fraction >65  %). CONCLUSIONS: A Hymenoptera sting may be a specific cause of @entity8 cardiac @entity3 . The presence of @entity5 and its etiology should prompt aggressive management including extracorporeal membrane oxygenation as a bridge to cardiac functional recovery in such rare scenarios.

title: Takotsubo cardiomyopathy caused by @entity4 -treated XXXX sting anaphylaxis: a case report.

answer: @entity7


abstract: INTRODUCTION: Stress-induced @entity1 (Takotsubo) after @entity7 stings in @entity0 who have received @entity6 is rare. Endogenous as well as exogenous administration of @entity6 is thought to trigger stress-induced @entity1 . CASE PRESENTATION: A 37-year-old healthy white @entity0 was stung by an unknown Hymenoptera that resulted in an anaphylactic reaction. Intravenous @entity4 (0.9  mg) was administered at a nearby clinic; she was transferred to our emergency room. @entity5 was diagnosed and mechanical ventilation commenced. Hemodynamic stabilization was not achieved by inotropic support and intra-aortic balloon pump insertion. Initial coronary angiography did not demonstrate any @entity2 while her left ventricular systolic function was severely @entity3 . Peripheral femoral venoarterial extracorporeal membrane oxygenation was inserted as a bridge to recovery assuming possible reversible cause of the @entity5 . Over the following 48  hours she was extubated and gradually weaned off venoarterial extracorporeal membrane oxygenation and inotropic support. She was discharged with a near normal left ventricular ejection fraction and in 3  weeks she was asymptomatic with normal electrocardiographic and echocardiographic examinations (left ventricular ejection fraction >65  %). CONCLUSIONS: A Hymenoptera sting may be a specific cause of @entity8 cardiac @entity3 . The presence of @entity5 and its etiology should prompt aggressive management including extracorporeal membrane oxygenation as a bridge to cardiac functional recovery in such rare scenarios.

title: Takotsubo cardiomyopathy caused by XXXX -treated @entity7 sting anaphylaxis: a case report.

answer: @entity4


abstract: BACKGROUND: @entity2 , @entity8 , and @entity2 are all forms of immunologically mediated @entity5 . Recognition that more than one of these diseases may co-exist is necessary for proper @entity0 management. OBJECTIVE: To report a case of extrinsic (cat) @entity6 , @entity8 , @entity2 , and potentially fatal @entity6 . Immunologic mechanisms and treatment of these diseases are discussed. METHODS: The study is a case report from a university hospital setting. Serum precipitating antibodies against avian antigens were measured using gel-diffusion technique. Serum IgE levels were measured and skin testing was performed to selected antigens. RESULTS: The @entity0 had positive cutaneous reactivity to cat antigen and Aspergillus. Serology for @entity8 and serum precipitating antibodies to finch extract were positive. Symptoms improved and @entity3 requirements decreased after removal of finches. CONCLUSION: A case of cat @entity6 , potentially fatal @entity6 , @entity8 , and @entity2 is presented. Early recognition and treatment of @entity7 with avoidance measures and use of @entity4 can prevent progressive @entity1 .

title: XXXX : a case report.

answer: @entity7


abstract: Micronutrients play a key role in many of the metabolic processes that promote survival from @entity4 . For @entity3 , these processes include oxidative phosphorylation, which is altered in the @entity0 with systemic @entity1 , and protection against mediators, in particular oxidants. Trace elements are essential for direct antioxidant activity as well as functioning as cofactors for a variety of antioxidant enzymes. @entity2 and immune function also depend on adequate levels of vitamins and trace elements (Table 6). Of extreme importance is the ease with which a deficiency state can develop in the critically ill because of decreased nutrient intakes and increased requirements. Daily intakes up to or exceeding many times the RDA usually are required. The enteral route is preferred, although, if not available, most of these agents can be given by the parenteral route. In that case, however, dose recommendations are less clear. Attention to micronutrients is paramount both in optimizing the nutritional management of the critically ill and in the overall management of these @entity0 . It also is essential in promoting positive outcomes and decreasing complications.

title: Micronutrients in XXXX .

answer: @entity4


abstract: A randomized prospective study was carried out to compare one-portal endoscopic @entity2 release with an open procedure. There were 47 @entity0 (mean age 52.6 years); 25 underwent an endoscopic and 22 an open release. The aim of the study was to evaluate the risks against the benefits for @entity1 , grip, key-pinch strength and ability to return to work. The distribution of age, occupation, sex, neurographic findings and operated hand was similar in both groups. We detected no serious nerve complications. One "open" @entity0 developed a @entity3 , a second "open" @entity0 a disabling @entity4 , one "endo" @entity0 a transient neurapraxia. The remaining @entity0 experienced complete relief of symptoms. Improvement of grip strength is significantly better after endoscopic release (P = 0.0001 at 3 months). In contrast, the key-pinch showed a similar pattern of improvement in both groups. The ability to use the operated hand as effectively as the contralateral one developed after 24 days for the endoscopic group versus 42 for the open approach (P = 0.0000). The carpal arch alteration was less important for the endoscopic group (P = 0.013), but without any correlation with the grip strength. Agee's one-portal technique only allows correct placement of a knife, not an inspection of the structures being operated upon. This is a major limitation, reducing the surgeon to a technician. Further development of this procedure demands a device that will enable a fruitful inspection of the @entity2 .

title: The value of one-portal endoscopic XXXX release: a prospective randomized study.

answer: @entity2


abstract: A 68-year-old @entity0 had been complained of @entity12 since she was 30 years old. Further symptoms of @entity11 , polyposia and @entity2 had been developed since she was 35 years old. The biopsy material from a minor salivary gland demonstrated the infiltration of lymphocytes into mesenchyme which was compatible with @entity3 . She admitted to our hospital because of @entity7 in bilateral gastrocnemius and petechiae in both lower extremities in addition to the complaints described above. Complete blood cell counts on admission revealed hemoglobin 9.7 g/dl, platelet count 12.5 x 10(4)/microliters, and white blood cell count 3,300/microliters. Marked @entity11 , polyposia (more than 5,000 ml/day, respectively) and low urine gravity (1.005) were observed, although the serum @entity8 level showed normal value. Serologic examination showed that the elevation of total serum protein concentration (9.5 g/dl) with marked elevation of serum IgG level (6,190 mg/dl). Her immunoglobulins contained cryoglobulin (cryocrit 20%), and immunoelectrophoresis demonstrated the existence of IgG-kappa monoclonal protein. A positive anti-nuclear antibody at 1:320 dilution, a positive rheumatoid factor and a positive antibody to @entity14 (Ro) were also observed. The serial studies of blood gas analysis could not demonstrated the presence of @entity4 . Together with the result of elevated plasma antidiuretic hormone level and results of @entity9 test, Fishberg's concentrating test and the tests of the overload of @entity15 or @entity13 , she was diagnosed @entity3 with both @entity10 and @entity1 . She was initially medicated with @entity5 (40 mg/day, orally), then she was given six courses of intravenous @entity6 (750 mg/body/month).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of @entity3 complicated with cryoglobulinemia, nephrogenic diabetes insipidus, and XXXX ].

answer: @entity1


abstract: A 68-year-old @entity0 had been complained of @entity12 since she was 30 years old. Further symptoms of @entity11 , polyposia and @entity2 had been developed since she was 35 years old. The biopsy material from a minor salivary gland demonstrated the infiltration of lymphocytes into mesenchyme which was compatible with @entity3 . She admitted to our hospital because of @entity7 in bilateral gastrocnemius and petechiae in both lower extremities in addition to the complaints described above. Complete blood cell counts on admission revealed hemoglobin 9.7 g/dl, platelet count 12.5 x 10(4)/microliters, and white blood cell count 3,300/microliters. Marked @entity11 , polyposia (more than 5,000 ml/day, respectively) and low urine gravity (1.005) were observed, although the serum @entity8 level showed normal value. Serologic examination showed that the elevation of total serum protein concentration (9.5 g/dl) with marked elevation of serum IgG level (6,190 mg/dl). Her immunoglobulins contained cryoglobulin (cryocrit 20%), and immunoelectrophoresis demonstrated the existence of IgG-kappa monoclonal protein. A positive anti-nuclear antibody at 1:320 dilution, a positive rheumatoid factor and a positive antibody to @entity14 (Ro) were also observed. The serial studies of blood gas analysis could not demonstrated the presence of @entity4 . Together with the result of elevated plasma antidiuretic hormone level and results of @entity9 test, Fishberg's concentrating test and the tests of the overload of @entity15 or @entity13 , she was diagnosed @entity3 with both @entity10 and @entity1 . She was initially medicated with @entity5 (40 mg/day, orally), then she was given six courses of intravenous @entity6 (750 mg/body/month).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of XXXX complicated with cryoglobulinemia, nephrogenic diabetes insipidus, and @entity1 ].

answer: @entity3


abstract: @entity7 ( @entity7 ) usually presents in association with @entity8 ( @entity8 ). In addition, the incidence of @entity6 tends to be increased in these @entity0 . A 74-year-old female with @entity7 presented with @entity2 and @entity1 . Contrast-enhanced multislice computed tomography (MSCT) revealed two left @entity8 and one in the right upper lobe. Both left @entity8 were treated with embolotherapy. Follow-up MSCT revealed an @entity5 in the right pulmonary branches. @entity4 was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of @entity3 . Finally, embolotherapy was performed. This case illustrates the chronic adaptation to @entity1 and adds further evidence to the relative safety of anticoagulation treatment in these @entity0 .

title: Huge XXXX and Anticoagulation Treatment in a @entity0 with @entity7 .

answer: @entity6


abstract: @entity7 ( @entity7 ) usually presents in association with @entity8 ( @entity8 ). In addition, the incidence of @entity6 tends to be increased in these @entity0 . A 74-year-old female with @entity7 presented with @entity2 and @entity1 . Contrast-enhanced multislice computed tomography (MSCT) revealed two left @entity8 and one in the right upper lobe. Both left @entity8 were treated with embolotherapy. Follow-up MSCT revealed an @entity5 in the right pulmonary branches. @entity4 was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of @entity3 . Finally, embolotherapy was performed. This case illustrates the chronic adaptation to @entity1 and adds further evidence to the relative safety of anticoagulation treatment in these @entity0 .

title: Huge @entity6 and Anticoagulation Treatment in a @entity0 with XXXX .

answer: @entity7


abstract: @entity7 ( @entity7 ) usually presents in association with @entity8 ( @entity8 ). In addition, the incidence of @entity6 tends to be increased in these @entity0 . A 74-year-old female with @entity7 presented with @entity2 and @entity1 . Contrast-enhanced multislice computed tomography (MSCT) revealed two left @entity8 and one in the right upper lobe. Both left @entity8 were treated with embolotherapy. Follow-up MSCT revealed an @entity5 in the right pulmonary branches. @entity4 was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of @entity3 . Finally, embolotherapy was performed. This case illustrates the chronic adaptation to @entity1 and adds further evidence to the relative safety of anticoagulation treatment in these @entity0 .

title: Huge @entity6 and Anticoagulation Treatment in a XXXX with @entity7 .

answer: @entity0


abstract: Natural killer (NK) activity was assayed in fresh peripheral blood mononuclear cells (PBMs) from @entity1 @entity0 receiving @entity3 ser. @entity0 received a single intravenous injection of @entity3 ser (90 x 10(6) IU m-2) on alternate days for 2 weeks, followed by a higher dose (180 x 10(6) IU m-2) on the same schedule. PBM NK lysis of K562 target cells was significantly increased in PBMs sampled 24 h after the initial injection (P < 0.05). At the end of the first 2 weeks of the protocol, NK cytotoxic activity of PBMs had fallen below the original baseline levels; the higher IFN dose subsequently given was without effect. However, significant increases in the proportion of @entity6 + cells were seen following each injection. A positive correlation was also seen between the increased lytic activity of @entity6 + NK cells and the proportion of @entity5 + NK cells, but not the proportion of @entity4 + NK cells. In vitro IFN-treatment of these in vivo-treated PBMs resulted in a further increase in NK activity. Pre-exposure in vivo to @entity3 ser seems to prime the PBMs to respond to in vitro stimulation by @entity2 , which otherwise had no effect. Phenotypic analysis of PBMs after in vitro exposure to @entity3 ser showed that the levels of @entity6 +, @entity5 + and @entity4 + cells did not change. All the NK activity responding to @entity3 ser was found in the @entity6 + enriched population of PBM, suggesting that it is unlikely that in vivo redistribution of @entity6 + subsets representative of NK cells has occurred in the peripheral blood.

title: In vivo priming effects of interferon-beta ser on NK activity of peripheral blood mononuclear cells in XXXX @entity0 .

answer: @entity1


abstract: Natural killer (NK) activity was assayed in fresh peripheral blood mononuclear cells (PBMs) from @entity1 @entity0 receiving @entity3 ser. @entity0 received a single intravenous injection of @entity3 ser (90 x 10(6) IU m-2) on alternate days for 2 weeks, followed by a higher dose (180 x 10(6) IU m-2) on the same schedule. PBM NK lysis of K562 target cells was significantly increased in PBMs sampled 24 h after the initial injection (P < 0.05). At the end of the first 2 weeks of the protocol, NK cytotoxic activity of PBMs had fallen below the original baseline levels; the higher IFN dose subsequently given was without effect. However, significant increases in the proportion of @entity6 + cells were seen following each injection. A positive correlation was also seen between the increased lytic activity of @entity6 + NK cells and the proportion of @entity5 + NK cells, but not the proportion of @entity4 + NK cells. In vitro IFN-treatment of these in vivo-treated PBMs resulted in a further increase in NK activity. Pre-exposure in vivo to @entity3 ser seems to prime the PBMs to respond to in vitro stimulation by @entity2 , which otherwise had no effect. Phenotypic analysis of PBMs after in vitro exposure to @entity3 ser showed that the levels of @entity6 +, @entity5 + and @entity4 + cells did not change. All the NK activity responding to @entity3 ser was found in the @entity6 + enriched population of PBM, suggesting that it is unlikely that in vivo redistribution of @entity6 + subsets representative of NK cells has occurred in the peripheral blood.

title: In vivo priming effects of interferon-beta ser on NK activity of peripheral blood mononuclear cells in @entity1 XXXX .

answer: @entity0


abstract: @entity3 is a leading cause of @entity1 death amongst males. The main clinical dilemma in treating @entity3 is the high number of indolent cases that confer a significant risk of overtreatment. In this study, we have performed gene expression profiling of @entity1 tissue specimens from 36 @entity0 with @entity3 to identify transcripts that delineate @entity2 and indolent @entity1 . Key genes were validated using previously published data and by tissue microarray analysis. Two molecular subgroups were identified with a significant overrepresentation of @entity1 from @entity0 with biochemical recurrence in one of the groups. We successfully validated key transcripts association with recurrence using two publically available datasets totaling 669 @entity0 . Twelve genes were found to be independent predictors of recurrence in multivariate logistical regression analysis. @entity4 gene expression was consistently up regulated in @entity0 with recurrence in all three datasets. Using an independent cohort of 536 @entity3 @entity0 we showed @entity4 expression to be an independent predictor of recurrence after prostatectomy (HR   =   1.35; p   =   0.009). We identified @entity4 to be associated with disease recurrence. Prospective studies are needed in order to assess the clinical usefulness of the identified key markers in this study.

title: Expression profiling of XXXX tissue delineates genes associated with recurrence after prostatectomy.

answer: @entity3


abstract: BACKGROUND: @entity2 (193 nm) excimer laser photorefractive keratectomy for @entity1 is under evaluation by the United States Food and Drug Administration. METHODS: We report a consecutive prospective series of 100 @entity0 (one eye per @entity0 ) treated as part of the Phase IIB FDA-approved protocol, with 80 @entity0 followed for 1 year. @entity0 ' ages ranged from 21 to 62 years (mean, 35 years). The Summit Technology, Inc ExciMed UV200LA with a 4.5-mm diameter ablation was used. RESULTS: Baseline spherical equivalent refraction ranged from -2.00 to -6.90 diopters (D) (mean -4.60 D). Ninety-five percent of eyes reepithelialized by 72 hours. At 1 year, the difference between attempted and achieved correction was +/- 0.50 D for 42 eyes (53%) and +/- 1.00 D for 60 eyes (75%). During the first 6 months, there was a trend toward overcorrection and the majority of eyes showed some loss of initial refractive correction; 10 eyes (14%) changed by 1.00 D or more between 6 and 12 months. An uncorrected visual acuity of 20/25 or better was achieved by 50 eyes (63%) and 20/40 or better by 61 eyes (77%). Of the 10 eyes (12%) that lost two or more Snellen lines of spectacle-corrected or glare visual acuity, two had visual acuity of worse than 20/25. Central subepithelial corneal haze was absent to mild in 77 (96%) eyes at 12 months. CONCLUSIONS: Excimer laser photorefractive keratectomy as performed in this study was generally effective and safe in reducing simple spherical @entity1 . Further studies of the effect of a larger diameter ablation zone, smoother transitional corneal contours, and the effect of postoperative topical corticosteroids may lead to further improvements in outcome.

title: Photorefractive keratectomy for XXXX using a 4.5-millimeter ablation zone.

answer: @entity1


abstract: INTRODUCTION: Great strides in pediatric @entity1 treatment are allowing hundreds of thousands of @entity0 to survive into adulthood. However, these treatments can be responsible for long-term medical and dental complications. The treatments may alter the @entity0 ' dental health and require modifications to standard orthodontic care. The aim of this study was to examine knowledge and clinical experience regarding orthodontic management of childhood @entity1 survivors. METHODS: A 12-question online survey consisting of 3 sections was sent to 2500 randomly selected members of the American Association of Orthodontists and all 2300 members of the Southern Association of Orthodontists. The first section consisted of questions about the respondents' practice characteristics, the second questioned how many survivor @entity0 the respondent had treated, and the third included questions about specific (anonymous) @entity0 experiences and treatment modifications. RESULTS AND CONCLUSIONS: There were 381 responses. The data from this study suggest a tendency for more experienced practitioners to have treated survivors of childhood @entity1 . Orthodontic education regarding the treatment of these @entity0 is limited. Although most orthodontists reported having treated such @entity0 , few had treated more than 10. There is a need for more @entity1 treatment and for guidelines for the orthodontic treatment of these @entity0 .

title: Experience and expertise regarding orthodontic management of childhood and adolescent XXXX survivors.

answer: @entity1


abstract: BACKGROUND: @entity2 ( @entity2 ) has several known risk factors. The association between @entity1 and @entity2 and the timeline of presentation are poorly defined. Our aim was to evaluate the associations between @entity2 and @entity1 . METHODS: We performed a retrospective cohort study of 1,074,236 @entity0 born between June 2001 and April 2012 in the US Military Health System. @entity2 cases and gestational ages (GA) were identified using billing codes. Additional risk factors for @entity2 were controlled for in a multivariable logistic regression model. RESULTS: The incidence of @entity2 was 2.99 per 1,000 in preterm @entity0 and 2.25 per 1,000 in full term (relative risk (RR) = 1.33, 95% confidence interval (CI) 1.16-1.54). The adjusted odds ratio for @entity1 was 1.26 (95% CI 1.08-1.46). The median (interquartile range (IQR)) chronological age at presentation was 40 d (30-56) in preterm @entity0 vs. 33 d (26-45) in full term (P < 0.001). Median postmenstrual age at presentation was 42   wk in preterm @entity0 (40-42) vs. 45   wk (44-46) in full term (P < 0.001). CONCLUSION: Prematurity is associated with @entity2 . Premature @entity0 develop @entity2 at a later chronological age, but earlier postmenstrual age, than term @entity0 . Providers should have an increased concern for @entity2 development in premature @entity0 .

title: Association of XXXX with the development of infantile hypertrophic pyloric stenosis.

answer: @entity1


abstract: OBJECTIVE: Paediatric severe @entity4 ( @entity4 ) is associated with significant @entity3 affective and behavioural problems. Few studies have examined the prevalence and characteristics of affective lability after paediatric @entity4 . METHODS: Ninety-seven @entity0 with severe @entity4 were evaluated 1 year @entity3 for the presence of affective lability using the @entity0 's Affective Lability Scale (CALS). Demographic, clinical and @entity2 characteristics were also assessed. RESULTS: Affective lability significantly increased after injury. Eighty-six @entity0 had a pre-injury CALS score of 1 SD or less from the group pre-injury mean (M   =   8.11, SD   =   9.31), of which 35 and 15 @entity0 had a 1 SD and 2 SD increase in their CALS score from pre- to @entity3 , respectively. A variety of affective shifts manifested @entity3 including @entity6 , silliness, dysphoria and @entity5 . The most severe symptoms were @entity5 and unpredictable temper outbursts. Risk factors for affective lability included elevated pre-injury affective lability and psychosocial adversity as well as greater damage to the orbitofrontal cortex. Post-injury affective lability was most frequently associated with a @entity3 diagnosis of @entity1 . CONCLUSIONS: Affective lability is common after paediatric @entity4 and frequently manifests as @entity5 and unpredictable outbursts. Early intervention is needed to improve @entity5 outcomes.

title: Prevalence and predictors of affective lability after paediatric XXXX .

answer: @entity4


abstract: @entity2 (NO) gas is known as both a vasodilator and a toxin. It can react with @entity0 to form compounds more @entity1 than itself, such as @entity4 ( @entity3 ). The reactions are time dependent; thus, infusing NO into breathing circuits as close to ventilated subjects as possible may help minimize @entity1 byproduct exposure. Unfortunately, flow rates commonly used with mechanical ventilation favor laminar gas flow (streaming) within the breathing circuits. Streaming could delay mixing of NO with other inhaled gases. This mixing delay may interfere with accurate monitoring and/or delivery of NO. We tested the hypothesis that streaming of NO infused by constant flow into the inspiratory limb of a constant-flow mechanical ventilation system can lead to NO concentration delivery estimate errors. We then compared the @entity3 concentrations at the ventilator Y-piece with three different NO mixing methods: blending the gases before they reach the breathing circuit inspiratory limb, infusing NO directly into the breathing circuit inspiratory limb far enough from the Y-piece to ensure thorough mixing, and infusing NO directly into the breathing circuit inspiratory limb immediately before the gases reach an in-line mixing device placed close to the Y-piece. Our results indicate that streaming can lead to NO concentration delivery estimate errors and that these errors can be characterized by measuring NO concentration variations across the inspiratory tubing's luminal diameter. @entity3 concentration measured at the ventilator Y-piece were dependent on NO concentrations (p < 0.0001), NO delivery methods (p < 0.0001), and interactions between NO concentrations and NO delivery methods (p < 0.0001). We conclude that gas streaming and @entity1 byproduct exposure should be considered together when choosing an NO delivery method.

title: XXXX administration using constant-flow ventilation.

answer: @entity2


abstract: OBJECTIVE: To explore validity of an assessment tool under development-the Emotional Inferencing from Stories Test (EIST). This measure is being designed to assess the ability of @entity0 with @entity3 ( @entity3 ) to make inferences about the emotional state of others solely from contextual cues. METHODS AND PROCEDURES: Study 1: 25 stories were presented to 40 healthy young adults. From this data, two versions of the EIST (EIST-1; EIST-2) were created. Study 2: Each version was administered to a group of @entity0 with moderate-to-severe @entity3 -EIST 1 group: 77 @entity0 ; EIST-2 group: 126 @entity0 . @entity0 also completed a facial affect recognition (DANVA2-AF) test. @entity0 with @entity2 returned 2 weeks later and were re-administered both tests. MAIN OUTCOMES: @entity0 with @entity3 scored significantly lower than the healthy group mean for EIST-1, F(1,114)   =   68.49, p   <   0.001, and EIST-2, F(1,163)   =   177.39, p   <   0.001. EIST scores in the EIST-2 group were significantly lower than the EIST-1 group, t   =   4.47, p   <   0.001. DANVA2-AF scores significantly correlated with EIST scores, EIST-1: r   =   0.50, p   <   0.001; EIST-2: r   =   0.31, p   <   0.001. Test-re-test reliability scores for the EIST were adequate. CONCLUSIONS: Both versions of the EIST were found to be sensitive to @entity1 . After further development, the EIST may provide clinicians valuable information for intervention planning.

title: Exploration of a new tool for assessing emotional inferencing after XXXX .

answer: @entity3


abstract: UNASSIGNED: 'Off-the-shelf' tissue-engineered skin alternatives for epidermal and dermal skin layers are available; however, no such alternative for the subdermal fat layer exists. Without this well-vascularized layer, skin graft take is variable and grafts may have reduced mobility, @entity3 and contour defects. In this study a novel adipose-derived acellular matrix (Adipogel) was investigated for its properties to generate subdermal fat in a @entity0 model. In a dorsal @entity4 site, a 1   *   1   cm Adipogel implant was inserted within a subdermal fat @entity2 . In a dorsal lumbar site, an Adipogel implant was inserted in a subfascial pocket. Contralateral control defects remained empty. At 8   weeks wound/implant sites were evaluated histologically, immunohistochemically and morphometrically. Identifiable @entity4 Adipogel implants lost volume in vivo over 8   weeks. @entity5 and adipogenesis were evident within implants and adipocyte percentage volume was 33.07        6.55% (mean        SEM). A comparison of entire cross-sections of @entity4 wounds demonstrated a significant @entity1 (37.19        4.48%, mean        SEM) compared to control (16.53        4.60%; p   =   0.0092), indicating that some Adipogel had been completely converted to normal fat. At the lumbar site, Adipogel also lost volume, appearing flattened, although fat generation and angiogenesis occurred. At both sites macrophage infiltration was mild, whilst many infiltrating cells were @entity6 -positive mesenchymal cells. Adipogel is adipogenic and angiogenic and is a promising candidate for subcutaneous fat regeneration; it has the potential to be a valuable adjunct to wound-healing therapy and reconstructive surgery practice. Copyright    2015 John Wiley _ Sons, Ltd.

title: An adipogenic gel for surgical reconstruction of the subcutaneous fat layer in a XXXX model.

answer: @entity0


abstract: We examine the origins of surgical therapy, radiotherapy, and chemotherapy as they were applied to @entity1 in the mid-portion of this century. Surgical therapy for @entity1 started in the 1930s with pneumonectomies. The prognostic significance of nodal @entity2 was soon recognized, and surgical staging procedures became an important part of @entity0 workup. Radical radiotherapy for potential cure of @entity1 began in the 1950s with megavoltage linear accelerators. The first application of chemotherapy for @entity1 was the use of @entity6 mustards in the 1940s. Single modality surgical therapy has become the treatment of choice for Stages I and II @entity5 , but 50% of clinical Stage I @entity0 die of recurrent disease, and 70% of those recur outside the chest. Biologic markers may identify high risk subgroups of Stage I and II @entity0 who may benefit from adjuvant chemo- or radiotherapy. Within the last decade, several single and multi-institutional Phase II trials and two single institution Phase III trials have reported improved survival in Stage IIIA @entity0 treated with @entity4 -based neoadjuvant chemotherapy prior to surgical resection. These trials have reported high response and resectability rates, but at a substantial @entity3 . A new standard of care for Stage IIIA disease has not been conclusively established.

title: An historical perspective of multi-modality treatment for resectable XXXX .

answer: @entity5


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a @entity1 caused by abnormal accumulation of @entity3 , which are intracellular deposits composed primarily of aggregated @entity7 (aSyn). Although aSyn has been strongly implicated to induce @entity4 , overexpression of wild-type aSyn is shown to be insufficient to trigger formation of protein aggregates by itself. Therefore, investigating the possible mechanism underlying aSyn aggregation is essential to understand the pathogenesis of @entity3 . Previous studies have demonstrated that amyloid b (Ab), the primary cause of @entity2 ( @entity2 ), may promote the formation of aSyn inclusion bodies. However, it remains unclear how Ab contributes to the deposition and @entity4 of aSyn. In the present study, we investigated the cytotoxic effects of Ab in aSyn-overexpressed neuronal cells. Our results showed that Ab inhibits autophagy and enhances aSyn aggregation in aSyn-overexpressed cells. Moreover, Ab also reduced @entity6 ( @entity6 ) and its downstream signaling, resulting in increased intracellular ROS accumulation and @entity5 . Our in vitro and in vivo studies support that Ab-inhibition of @entity8 -activated protein kinase (AMPK) signaling is involved in the @entity4 effects of aSyn. Taken together, our findings suggest that Ab plays a synergistic role in aSyn aggregation and @entity0 , which may provide a novel understanding for exploring the underlying molecular mechanism of @entity3 .

title: Amyloid-b suppresses @entity8 -activated protein kinase (AMPK) signaling and contributes to @entity7 -induced XXXX .

answer: @entity0


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a @entity1 caused by abnormal accumulation of @entity3 , which are intracellular deposits composed primarily of aggregated @entity7 (aSyn). Although aSyn has been strongly implicated to induce @entity4 , overexpression of wild-type aSyn is shown to be insufficient to trigger formation of protein aggregates by itself. Therefore, investigating the possible mechanism underlying aSyn aggregation is essential to understand the pathogenesis of @entity3 . Previous studies have demonstrated that amyloid b (Ab), the primary cause of @entity2 ( @entity2 ), may promote the formation of aSyn inclusion bodies. However, it remains unclear how Ab contributes to the deposition and @entity4 of aSyn. In the present study, we investigated the cytotoxic effects of Ab in aSyn-overexpressed neuronal cells. Our results showed that Ab inhibits autophagy and enhances aSyn aggregation in aSyn-overexpressed cells. Moreover, Ab also reduced @entity6 ( @entity6 ) and its downstream signaling, resulting in increased intracellular ROS accumulation and @entity5 . Our in vitro and in vivo studies support that Ab-inhibition of @entity8 -activated protein kinase (AMPK) signaling is involved in the @entity4 effects of aSyn. Taken together, our findings suggest that Ab plays a synergistic role in aSyn aggregation and @entity0 , which may provide a novel understanding for exploring the underlying molecular mechanism of @entity3 .

title: Amyloid-b suppresses @entity8 -activated protein kinase (AMPK) signaling and contributes to XXXX -induced @entity0 .

answer: @entity7


abstract: UNASSIGNED: @entity3 ( @entity3 ) is a @entity1 caused by abnormal accumulation of @entity3 , which are intracellular deposits composed primarily of aggregated @entity7 (aSyn). Although aSyn has been strongly implicated to induce @entity4 , overexpression of wild-type aSyn is shown to be insufficient to trigger formation of protein aggregates by itself. Therefore, investigating the possible mechanism underlying aSyn aggregation is essential to understand the pathogenesis of @entity3 . Previous studies have demonstrated that amyloid b (Ab), the primary cause of @entity2 ( @entity2 ), may promote the formation of aSyn inclusion bodies. However, it remains unclear how Ab contributes to the deposition and @entity4 of aSyn. In the present study, we investigated the cytotoxic effects of Ab in aSyn-overexpressed neuronal cells. Our results showed that Ab inhibits autophagy and enhances aSyn aggregation in aSyn-overexpressed cells. Moreover, Ab also reduced @entity6 ( @entity6 ) and its downstream signaling, resulting in increased intracellular ROS accumulation and @entity5 . Our in vitro and in vivo studies support that Ab-inhibition of @entity8 -activated protein kinase (AMPK) signaling is involved in the @entity4 effects of aSyn. Taken together, our findings suggest that Ab plays a synergistic role in aSyn aggregation and @entity0 , which may provide a novel understanding for exploring the underlying molecular mechanism of @entity3 .

title: Amyloid-b suppresses XXXX -activated protein kinase (AMPK) signaling and contributes to @entity7 -induced @entity0 .

answer: @entity8


abstract: UNASSIGNED: While it has recently been shown that @entity9 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity9 neuroprotection. In addition, it is not known whether @entity9 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity2 ( @entity8 )-induced @entity1 model, the effects and mechanisms of time-dependent treatment with @entity9 (beginning 15days after @entity4 and continuing for 15days, or @entity6 concomitantly with @entity4 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity1 induced by @entity8 in rodents has been widely used as a model of @entity0 ( @entity0 ). In the present study, five male C57BL/6 @entity3 aged 7-10weeks were used per group. For four weeks, the groups received either @entity2 ( @entity8 ) 0.2% mixed in feed or @entity8 combined with the administration of @entity9 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity6 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity8 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity8 0.3%. @entity8 induced an increase in the expression of @entity5 and a decrease in @entity10 , @entity12 , @entity11 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity7 , @entity10 , and @entity12 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity11 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity6 after the installation of the degenerative process. Therefore, the present study shows that @entity9 modulates inflammation, with the involvement of @entity7 , @entity10 , and @entity12 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity9 and contribute to the control of @entity4 such as @entity0 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity10 / @entity12 and @entity7 regulation in a @entity2 -induced XXXX model.

answer: @entity1


abstract: UNASSIGNED: While it has recently been shown that @entity9 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity9 neuroprotection. In addition, it is not known whether @entity9 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity2 ( @entity8 )-induced @entity1 model, the effects and mechanisms of time-dependent treatment with @entity9 (beginning 15days after @entity4 and continuing for 15days, or @entity6 concomitantly with @entity4 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity1 induced by @entity8 in rodents has been widely used as a model of @entity0 ( @entity0 ). In the present study, five male C57BL/6 @entity3 aged 7-10weeks were used per group. For four weeks, the groups received either @entity2 ( @entity8 ) 0.2% mixed in feed or @entity8 combined with the administration of @entity9 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity6 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity8 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity8 0.3%. @entity8 induced an increase in the expression of @entity5 and a decrease in @entity10 , @entity12 , @entity11 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity7 , @entity10 , and @entity12 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity11 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity6 after the installation of the degenerative process. Therefore, the present study shows that @entity9 modulates inflammation, with the involvement of @entity7 , @entity10 , and @entity12 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity9 and contribute to the control of @entity4 such as @entity0 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity10 / @entity12 and @entity7 regulation in a XXXX -induced @entity1 model.

answer: @entity2


abstract: UNASSIGNED: While it has recently been shown that @entity9 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity9 neuroprotection. In addition, it is not known whether @entity9 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity2 ( @entity8 )-induced @entity1 model, the effects and mechanisms of time-dependent treatment with @entity9 (beginning 15days after @entity4 and continuing for 15days, or @entity6 concomitantly with @entity4 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity1 induced by @entity8 in rodents has been widely used as a model of @entity0 ( @entity0 ). In the present study, five male C57BL/6 @entity3 aged 7-10weeks were used per group. For four weeks, the groups received either @entity2 ( @entity8 ) 0.2% mixed in feed or @entity8 combined with the administration of @entity9 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity6 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity8 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity8 0.3%. @entity8 induced an increase in the expression of @entity5 and a decrease in @entity10 , @entity12 , @entity11 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity7 , @entity10 , and @entity12 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity11 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity6 after the installation of the degenerative process. Therefore, the present study shows that @entity9 modulates inflammation, with the involvement of @entity7 , @entity10 , and @entity12 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity9 and contribute to the control of @entity4 such as @entity0 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity10 / @entity12 and XXXX regulation in a @entity2 -induced @entity1 model.

answer: @entity7


abstract: UNASSIGNED: While it has recently been shown that @entity9 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity9 neuroprotection. In addition, it is not known whether @entity9 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity2 ( @entity8 )-induced @entity1 model, the effects and mechanisms of time-dependent treatment with @entity9 (beginning 15days after @entity4 and continuing for 15days, or @entity6 concomitantly with @entity4 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity1 induced by @entity8 in rodents has been widely used as a model of @entity0 ( @entity0 ). In the present study, five male C57BL/6 @entity3 aged 7-10weeks were used per group. For four weeks, the groups received either @entity2 ( @entity8 ) 0.2% mixed in feed or @entity8 combined with the administration of @entity9 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity6 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity8 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity8 0.3%. @entity8 induced an increase in the expression of @entity5 and a decrease in @entity10 , @entity12 , @entity11 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity7 , @entity10 , and @entity12 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity11 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity6 after the installation of the degenerative process. Therefore, the present study shows that @entity9 modulates inflammation, with the involvement of @entity7 , @entity10 , and @entity12 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity9 and contribute to the control of @entity4 such as @entity0 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity10 / XXXX and @entity7 regulation in a @entity2 -induced @entity1 model.

answer: @entity12


abstract: UNASSIGNED: While it has recently been shown that @entity9 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity9 neuroprotection. In addition, it is not known whether @entity9 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity2 ( @entity8 )-induced @entity1 model, the effects and mechanisms of time-dependent treatment with @entity9 (beginning 15days after @entity4 and continuing for 15days, or @entity6 concomitantly with @entity4 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity1 induced by @entity8 in rodents has been widely used as a model of @entity0 ( @entity0 ). In the present study, five male C57BL/6 @entity3 aged 7-10weeks were used per group. For four weeks, the groups received either @entity2 ( @entity8 ) 0.2% mixed in feed or @entity8 combined with the administration of @entity9 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity6 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity8 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity8 0.3%. @entity8 induced an increase in the expression of @entity5 and a decrease in @entity10 , @entity12 , @entity11 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity7 , @entity10 , and @entity12 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity11 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity6 after the installation of the degenerative process. Therefore, the present study shows that @entity9 modulates inflammation, with the involvement of @entity7 , @entity10 , and @entity12 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity9 and contribute to the control of @entity4 such as @entity0 .

title: Phosphodiesterase-5 inhibition promotes remyelination by XXXX / @entity12 and @entity7 regulation in a @entity2 -induced @entity1 model.

answer: @entity10


abstract: UNASSIGNED: Despite the high risk of @entity1 to the population, Korean Americans are known to have lower knowledge about @entity1 related information and a lower level of adherence to @entity1 prevention guidelines. This indicates the necessity of @entity1 interventions targeting the Korean American population. To reach this population effectively, it is imperative to understand Korean Americans' @entity1 information seeking behaviors. This study (a) identified @entity1 information sources that are trusted and used by Korean American @entity0 and (b) examined how general media exposure and trust in @entity1 information sources are related to the use of these sources. It also (c) explored perceived usefulness and limitations of @entity1 information sources. A mixed methods study using seven focus group interviews with 34 Korean American @entity0 and surveys with 152 Korean American @entity0 was conducted in the Washington, DC, metropolitan area from 2011 to 2012. The results indicate that Korean American @entity0 viewed health care professionals as the most trusted @entity1 information source but used the Internet and Korean ethnic media more often for @entity1 information seeking because of language, cultural, and economic barriers. Korean American @entity0 were most likely to obtain @entity1 information from media they used frequently for general purposes. Correlations between usage frequency and trust in doctor/health providers and the Internet as @entity1 information sources were negligible. When seeking @entity1 information, important factors for Korean American @entity0 were accessibility, affordability, and language proficiency, cultural sensitivity, meeting immediate needs, understandability, convenience, and reliability of @entity1 information sources. Findings from this study support developing interventions using Korean language media, including print, television and the Internet for health promotion and @entity1 prevention targeting Korean American @entity0 .

title: Cancer Information Seeking Behaviors of Korean American XXXX : A Mixed-Methods Study Using Surveys and Focus Group Interviews.

answer: @entity0


abstract: PURPOSE: Current clinical practice guidelines sometimes still recommend stopping @entity1 five to seven days before knee arthroplasty surgery. Literature regarding multimodal blood management and continuation of anti-platelet therapy in this type of surgery is scant. The study hypothesis was that knee arthroplasty under low-dose @entity1 mono-therapy continuation does not cause more @entity2 than knee arthroplasty performed without @entity1 . @entity2 would be measured by haemoglobin (Hb) and haematocrit (HTC) levels drop at day 2 or day 4 for @entity0 who benefit from multimodal @entity3 control measures. METHODS: A database of all @entity0 undergoing knee arthroplasty between 2006 and 2014 was analysed. @entity4 were collected. A retrospective comparison study analysed both groups in terms of @entity2 , by mean calculated @entity2 as haemoglobin or haematocrit drop between the preoperative Nadir value and the postoperative day 2 and 4 value. A group of 198 (44 UKA and 154 TKA) @entity0 underwent surgery without interrupting their @entity1 therapy for cardiovascular prevention. Mean (SD) age was 71 (8) and the mean (SD) BMI was 29 (5.5) kg/m(2). The control group consisted of 403 (102 UKA and 301 TKA) @entity0 who were not under @entity1 , or any other anti-platelet agent. Mean (SD) age was 65 (10) (p  <  0.05) and the mean (SD) BMI was 29 (5.0) kg/m(2) (n.s.). All @entity0 in the control group were randomly selected. RESULTS: There were no differences in terms of visible (early) or hidden (late) @entity2 as measured by Hb drop in between both groups. There is no difference in transfusion rates. CONCLUSIONS: Modern multimodal blood management provides sufficient @entity2 prevention during and after knee arthroplasty to allow physicians to continue low-dose @entity1 mono-therapy for cardiovascular prevention. LEVEL OF EVIDENCE: III.

title: XXXX mono-therapy continuation does not result in more @entity3 after knee arthroplasty.

answer: @entity1


abstract: PURPOSE: Current clinical practice guidelines sometimes still recommend stopping @entity1 five to seven days before knee arthroplasty surgery. Literature regarding multimodal blood management and continuation of anti-platelet therapy in this type of surgery is scant. The study hypothesis was that knee arthroplasty under low-dose @entity1 mono-therapy continuation does not cause more @entity2 than knee arthroplasty performed without @entity1 . @entity2 would be measured by haemoglobin (Hb) and haematocrit (HTC) levels drop at day 2 or day 4 for @entity0 who benefit from multimodal @entity3 control measures. METHODS: A database of all @entity0 undergoing knee arthroplasty between 2006 and 2014 was analysed. @entity4 were collected. A retrospective comparison study analysed both groups in terms of @entity2 , by mean calculated @entity2 as haemoglobin or haematocrit drop between the preoperative Nadir value and the postoperative day 2 and 4 value. A group of 198 (44 UKA and 154 TKA) @entity0 underwent surgery without interrupting their @entity1 therapy for cardiovascular prevention. Mean (SD) age was 71 (8) and the mean (SD) BMI was 29 (5.5) kg/m(2). The control group consisted of 403 (102 UKA and 301 TKA) @entity0 who were not under @entity1 , or any other anti-platelet agent. Mean (SD) age was 65 (10) (p  <  0.05) and the mean (SD) BMI was 29 (5.0) kg/m(2) (n.s.). All @entity0 in the control group were randomly selected. RESULTS: There were no differences in terms of visible (early) or hidden (late) @entity2 as measured by Hb drop in between both groups. There is no difference in transfusion rates. CONCLUSIONS: Modern multimodal blood management provides sufficient @entity2 prevention during and after knee arthroplasty to allow physicians to continue low-dose @entity1 mono-therapy for cardiovascular prevention. LEVEL OF EVIDENCE: III.

title: @entity1 mono-therapy continuation does not result in more XXXX after knee arthroplasty.

answer: @entity3


abstract: @entity4 is rare and mostly occurs because of @entity3 and dental procedures. Furthermore, cellulitis caused by iatrogenic foreign bodies is very rare. A 28-year-old @entity0 who had previously undergone cosmetic bimaxillary operation visited our hospital complaining of left facial swelling, @entity2 , and nasal obstruction since 2 years. She had been attending another clinic, but despite having additional procedures and taking medications, her symptoms persisted. A subsequent operation was performed, during which we found a remnant surgical gauze from the previous operation, which was decomposed and trapped around the @entity1 soft tissue and had eroded the bony structure around the pterygoid fossa. The material was successfully removed by endoscopic surgery, and the @entity1 tissue was debrided. After the operation, all symptoms disappeared, and the @entity0 was discharged without sequelae. During any procedure, surgeons must meticulously check for remnant material. Additionally, physicians must carefully note @entity0 history and perform a physical examination, even in @entity0 without serious symptoms. We report a case of advanced @entity4 due to remnant gauze material during a previous operation that was undetected.

title: XXXX caused by a remnant iatrogenic foreign body after a bimaxillary operation.

answer: @entity4


abstract: Invasive @entity1 has been shown to be etiologically heterogeneous on the basis of pathological, virological, and epidemiological criteria. @entity3 -related invasive @entity1 has basaloid or warty morphology and has adjacent basaloid or warty @entity5 . @entity1 unrelated to @entity3 is a keratinizing @entity2 that may have adjacent @entity4 . We provided to 3 pathologists for their review and pathological diagnoses stained tissue sections from 95 @entity0 with @entity1 . The reproducibility for grading individual categories of intraepithelial lesions was only fair (kappa values of 0.31-0.43). The reproducibility was better (moderate to good; kappa values of 0.58-0.59) for grading individual categories of invasive @entity1 . The agreements improved when the basaloid and warty categories were combined. Good agreement was achieved (kappa values of 0.55-0.79) in distinguishing @entity3 -related lesions from those unrelated to @entity3 ; all three reviewers agreed on this classification for 67% of the cases. The intrareviewer agreement was of the same order as interreviewer agreement. Difficulties in differentiating between some lesions (e.g., a @entity1 with little atypia from a well- to moderately differentiated keratinizing @entity2 ) and concurrent occurrence of @entity3 -related lesions and those lesions unrelated to @entity3 in a @entity0 may account for some of the discrepancies in the histopathological diagnoses of @entity1 .

title: Reproducibility of the histopathological classification of XXXX and @entity5 .

answer: @entity2


abstract: Invasive @entity1 has been shown to be etiologically heterogeneous on the basis of pathological, virological, and epidemiological criteria. @entity3 -related invasive @entity1 has basaloid or warty morphology and has adjacent basaloid or warty @entity5 . @entity1 unrelated to @entity3 is a keratinizing @entity2 that may have adjacent @entity4 . We provided to 3 pathologists for their review and pathological diagnoses stained tissue sections from 95 @entity0 with @entity1 . The reproducibility for grading individual categories of intraepithelial lesions was only fair (kappa values of 0.31-0.43). The reproducibility was better (moderate to good; kappa values of 0.58-0.59) for grading individual categories of invasive @entity1 . The agreements improved when the basaloid and warty categories were combined. Good agreement was achieved (kappa values of 0.55-0.79) in distinguishing @entity3 -related lesions from those unrelated to @entity3 ; all three reviewers agreed on this classification for 67% of the cases. The intrareviewer agreement was of the same order as interreviewer agreement. Difficulties in differentiating between some lesions (e.g., a @entity1 with little atypia from a well- to moderately differentiated keratinizing @entity2 ) and concurrent occurrence of @entity3 -related lesions and those lesions unrelated to @entity3 in a @entity0 may account for some of the discrepancies in the histopathological diagnoses of @entity1 .

title: Reproducibility of the histopathological classification of @entity2 and XXXX .

answer: @entity5


abstract: INTRODUCTION: Few studies have investigated links between @entity0 abuse and neglect and @entity1 in nationally representative samples, and none have explored the role of @entity2 in the relationship. We sought to determine whether @entity0 abuse and neglect were associated with @entity1 and if so, whether @entity2 mediated this relationship in a population-representative sample of young adults. METHODS: We used data from 14,493 @entity0 aged 24 to 34 years from Wave IV of the National Longitudinal Study of Adolescent Health to study associations between self-reported @entity0 abuse ( @entity3 ) and neglect as @entity0 and @entity1 or @entity4 in young adulthood. We conducted sex-stratified logistic regression analyses to evaluate associations in models before and after the addition of body mass index (BMI) as a covariate. RESULTS: Although the prevalence of @entity1 was similar for @entity0 and @entity0 (7.0% vs 6.7%), @entity0 were more likely than @entity0 to have @entity4 (36.3% vs 24.6%; omnibus P < .001). Among @entity0 , recurrent @entity3 (>= 3 lifetime incidents) was significantly associated with @entity1 (OR, 3.66; 95% CI, 1.31-10.24), but not with @entity4 . There was no evidence of mediation by BMI. No forms of @entity0 abuse or neglect were associated with @entity1 or @entity4 among @entity0 . CONCLUSIONS: Recurrent @entity3 is robustly associated with @entity1 in young adult @entity0 , independently of other forms of @entity0 abuse or neglect and BMI. Future research should explore other potential mechanisms for this association to identify avenues for prevention of @entity1 among @entity0 who have experienced @entity3 .

title: Relationship Between Abuse and Neglect in Childhood and XXXX in Adulthood: Differential Effects By Sex, National Longitudinal Study of Adolescent Health.

answer: @entity1


abstract: BACKGROUND AND AIM: Mesenchymal precursor cells (MPC) are reported to possess immunomodulatory properties that may prove beneficial in autoimmune and other inflammatory conditions. However, their mechanism of action is poorly understood. A collagen-induced @entity3 model has been previously developed which demonstrates @entity0 and systemic inflammatory changes. These include not only increased levels of inflammatory markers, but also vascular endothelial cell dysfunction, characterised by reduced endothelium-dependent vasodilation. This study aimed to characterise the changes in systemic inflammatory markers and endothelial function following the intravenous administration of MPC, in the ovine model. METHODS: @entity3 was induced in sixteen adult @entity4 by administration of @entity1 type II collagen into the hock joint following initial sensitisation. After 24h, @entity4 were administered either 150 million allogeneic ovine MPCs intravenously, or saline only. Fibrinogen and serum amyloid-A were measured in plasma to assess systemic @entity0 , along with pro-inflammatory and anti-inflammatory cytokines. Animals were necropsied two weeks following @entity3 induction. Coronary and digital arterial segments were mounted in a Mulvaney-Halpern wire myograph. The relaxant response to endothelium-dependent and endothelium-independent vasodilators was used to assess @entity2 . RESULTS AND CONCLUSION: Arthritic @entity4 treated with MPC demonstrated a marked spike in plasma @entity6 , 24h following MPC administration. They also showed significantly reduced plasma levels of the inflammatory markers, fibrinogen and serum amyloid A, and increased HDL. Coronary arteries from RA @entity4 treated with MPCs demonstrated a significantly greater maximal relaxation to @entity5 when compared to untreated RA @entity4 (253.6    17.1% of pre-contracted tone vs. 182.3    27.3% in controls), and digital arteries also demonstrated greater endothelium-dependent vasodilation. This study demonstrated that MPCs given intravenously are able to attenuate systemic inflammatory changes associated with a monoarthritis, including the development of @entity2 .

title: Effect of Mesenchymal Precursor Cells on the Systemic Inflammatory Response and Endothelial Dysfunction in an Ovine Model of Collagen-Induced XXXX .

answer: @entity3


abstract: BACKGROUND: The authors' objective was to determine retrospectively the methods used to follow up @entity2 of undetermined significance (AGUS) on Papanicolaou smears and to evaluate the effectiveness of those methods. MATERIAL AND METHODS: The charts of all @entity0 with AGUS smears obtained between February 1993 and April 1996 were reviewed retrospectively, and information was extracted. A computer database was used to identify the @entity0 and review the method of evaluation. The findings from histological sampling also are reported and analyzed. All findings are reported descriptively. RESULTS: Seventy-nine AGUS smears were evaluated. Of these, it was found that six @entity0 had no follow-up. Of the 62 with histological followup, most (74%) underwent colposcopy, endometrial biopsy (63%), or endocervical curettage (50%). Cervical or vaginal biopsy, cervical conization, hysteroscopy, and hysterectomy also were performed. Twenty-seven @entity0 underwent more than one procedure for tissue sampling. Of the 62 @entity0 from whom histological samples were taken, 18 (29%) were found to have clinically significant lesions, 11 of which were @entity1 . CONCLUSIONS: In our clinic, AGUS smears are a result of a significant number of high-grade neoplastic findings. Histological evaluation is necessary in most cases for accurate diagnosis because of the multiple, varied potential etiologies of AGUS smears.

title: Papanicolaou smears showing XXXX of undetermined significance: a case series.

answer: @entity2


abstract: Importance: Nonsurgical treatment of advanced supraglottic @entity1 is widely used as part of a larynx preservation protocol. However, recent studies have suggested that nonsurgical treatment may be associated with inferior survival. Furthermore, it is not clear whether preservation of the larynx provides superior voice or swallowing function in the long term. Objective: To test the hypothesis that surgical treatment of advanced-stage @entity2 of the supraglottic larynx is associated with superior @entity3 ( @entity3 ), freedom from recurrence (FFR), and noninferior voice and swallowing function. Design, Setting, and @entity0 : Retrospective medical record review of @entity0 treated for stage III or @entity2 of the supraglottic larynx between January 1990 and June 2013 at a tertiary referral center: 97 @entity0 underwent surgical treatment and 138, nonsurgical treatment. Exclusion criteria included prior definitive treatment for @entity1 or evidence of distant metastatic disease at presentation. The median follow-up for all 235 @entity0 was 63 months. Interventions: Surgical or nonsurgical therapy. Main Outcomes and Measures: Freedom from recurrence (FFR), @entity3 , larynx preservation, voice graded from 1 to 5, and swallowing graded from 1 to 6 using our voice and swallowing function scales. Results: Surgical treatment was associated with superior FFR (5-year FFR: 75% vs 55%; P   =   .006) but not @entity3 (5-year @entity3 : 52% vs 52%; P   =   .61). The larynx was preserved in 83% of @entity0 in the nonsurgical group vs 42% of @entity0 in the surgical group (P   <   .001). Voice function was superior in the nonsurgical group at all time points through 5 years after treatment (mean voice score, 3.8 vs 2.6; P   <   .001). Swallowing function was comparable between surgical and nonsurgical groups. Multivariable analysis revealed that advanced age (hazard ratio [HR], 1.43 per 10-year increment; 95% CI, 1.19-1.72) and clinical N stage (HR, 1.17 per 1-level increment; 95% CI, 1.05-1.30) were associated with worse @entity3 , while treatment with chemotherapy was associated with superior @entity3 (HR, 0.61; 95% CI, 0.41-0.92). Conclusions and Relevance: Compared with surgical treatment, nonsurgical treatment as part of a larynx preservation protocol is associated with a higher likelihood of recurrence but has similar @entity3 and should continue to be viewed as a viable alternative for the treatment of advanced supraglottic @entity1 .

title: Oncologic and Functional Outcomes of Surgical and Nonsurgical Treatment of XXXX of the Supraglottic Larynx.

answer: @entity2


abstract: The aim of this study was to characterize Kenyan runners in regard to their @entity1 uptake and blood and @entity3 responses when running. Untrained Kenyan @entity0 (14.2 +/- 0.2 years) and Scandinavian runners were included for comparison. The studies were performed at altitude (approximately 2.000 m.a.s.l.) and, for several Kenyan and Scandinavian runners, at sea level as well. At altitude sedentary adolescent Kenyan @entity0 had a mean maximal @entity1 uptake (VO2max) of 47 (44-51) ml.kg-1.min-1, whereas similarly aged @entity0 regularly walking or running but not training for competition reached above 62 (58-71) ml.kg-1.min-1 in VO2max. Kenyan runners in active training had 68 +/- 1.4 ml.kg-1.min-1 at altitude and 79.9 +/- 1.4 ml.kg-1.min-1 at sea level, with individuals reaching 85 ml.kg-1.min-1. The best Scandinavian runners were not significantly different from the Kenyan runners in VO2max both at altitude and at sea level, but none of the Scandinavians reached as high individual values as observed for some Kenyan runners. The running efficiency, determined as the @entity1 cost at a given running speed, was less in the Kenyan runners, and the difference became more pronounced when body weight was expressed in ml.kg-0.75 min-1. Blood @entity2 concentration was in general lower in the Kenyan than in the Scandinavian runners, and the Kenyans also had extremely low @entity3 accumulation in the blood even at very high exercise intensities. It is concluded that it is the physical activity during childhood, combined with intense training as teenagers that brings about the high VO2max observed in some Kenyan runners. Their high aerobic capacity, as well as their good running economy, makes them such superior runners. In addition, their low blood lactate and @entity3 accumulation in blood when running may also be contributing factors.

title: Aerobic exercise capacity at sea level and at altitude in Kenyan XXXX , junior and senior runners compared with Scandinavian runners.

answer: @entity0


abstract: PURPOSE: Hemispherotomy (H) is the gold standard treatment to cure @entity2 in @entity1 ( @entity1 ). Linguistic prognosis after surgery remains the main issue when the dominant hemisphere is involved. The topic of the present research is to specify the long-term linguistic profile of the right hemisphere after left dominant H for @entity1 . METHODS: We followed 6 @entity0 8.4 to 14.6years of age who underwent left H for @entity1 . Preoperatively, four @entity0 experienced @entity3 , but for two, worsening occurred after surgery. Age at H ranged from 4.1 to 8.4years. The mean duration of @entity2 was 1.2years and 5.6years for follow-up. Neuropsychological evaluation included longitudinal follow-up of intellectual efficiency measurement and a long-term outcome of language using various components of receptive and expressive oral speech with computerized tasks. KEY FINDINGS: Preoperatively, verbal comprehension index (VCI) was dramatically decreased in 4/6 @entity0 , and performance reasoning index (PRI) was low in 5/6 @entity0 , demonstrating a global impact of @entity1 itself. Postoperatively, all @entity0 recovered sufficiently to attend a regular VCI (above 70) in a mean of 5years after @entity4 , and 5/6 recovered normal or adapted school. There was a dissociation in favor of VCI, while PRI decreased in 5/6 @entity0 . We found a specific linguistic profile for these @entity0 recovering language in the right hemisphere: normal verbal comprehension, and weakness of grammatical judgment, word repetition, statement production, semantic verbal fluency and metaphonological abilities. Language recovery scores were statistically correlated with those of Working Memory Index. SIGNIFICANCE: This study emphasizes for the first time the ability of the right hemisphere to functionally reorganize language over a long period of time following left H for @entity1 . Syntactic abilities and phonology remain low and support the hypothesis of an early left hemispheric specialization. Nevertheless, lexico-semantic processes recover in the right hemisphere that could reflect a pre-existing potential of both hemispheres. Our results support a decision to proceed to H in classical @entity1 until the late childhood even if there is no complete @entity3 before surgery. These data should be taken in account in the overall postoperative follow-up and rehabilitation strategy.

title: Language recovery after left hemispherotomy for XXXX .

answer: @entity1


abstract: BACKGROUND: Attempts aimed at inducing food tolerance through oral food desensitization (OFD) for the treatment of IgE-mediated @entity3 are increasing. In Italy, a number of @entity2 centres offer this procedure. OBJECTIVE: To collect information on how these centres are organized, how @entity0 are selected, the methods used to administer OFD and how adverse reactions are managed. METHODS: A questionnaire was e-mailed to all the Italian @entity2 centres offering OFD. RESULTS: The survey shows a high degree of variability between centres. A correct diagnosis of @entity3 is crucial for selecting @entity0 for OFD. In the Italian @entity2 centres, oral food challenges are mostly open label (84%), but in 16% of cases they are single-blind (8%) or double-blind (8%). A high proportion of @entity2 centres (83%) offer OFD to @entity0 presenting forms of anaphylaxis triggered by traces - or very low doses - of food allergen. The majority of @entity2 centres (76%) enroll @entity0 over 3 years of age, with 44% enrolling @entity0 above the age of 5. Not-controlled @entity1 , unreliability of parents in the management of OFD and/or risk of adverse events, are the main reasons for exclusion from the procedure. CONCLUSION: Although OFD may sometimes be successful and may be considered a valid alternative to an elimination diet, further randomized controlled trials are needed, in order to clarify some controversial points, such as the characteristics of the @entity0 undergoing OFD, and the methods of food preparation and administration. Moreover, further studies should further investigate OFD safety, efficacy and costs.

title: The oral food desensitization in the Italian XXXX centres.

answer: @entity2