abstract: BACKGROUND: The efficacy of postoperative radiotherapy (PORT) for thymic @entity1 is still controversial. Using the Japanese Association for Research on the Thymus (JART) database, this study was aimed at clarifying the efficacy of PORT for @entity1 and @entity3 . METHODS: The JART database registered the records of 2835 @entity0 collected from 32 Japanese institutions from 1991 to 2010. @entity3 and @entity3 at stage II or III were extracted. The efficacy of PORT with respect to @entity5 ( @entity5 ) and @entity4 ( @entity4 ) was evaluated with the Kaplan-Meier method and Cox regression analysis. RESULTS: There were 1265 @entity0 in all: 155 @entity3 cases (12.3%) and 1110 @entity3 cases (87.7%). Eight hundred ninety-five (70.8%) were at stage II, and 370 (29.2%) were at stage III. Four hundred three cases (31.9%) underwent PORT. PORT for @entity1 was associated with increasing @entity5 (hazard ratio, 0.48; 95% confidence interval, 0.30-0.78; P =   .003) but was not associated with @entity4 (hazard ratio, 0.94; 95% confidence interval, 0.51-1.75; P =   .536). PORT for @entity2 was not associated with @entity5 or @entity4 (P =   .350). A subgroup analysis of stage III @entity3 showed no factor associated with the efficacy of PORT. CONCLUSIONS: In this study, PORT did not increase @entity5 or @entity4 for @entity2 but increased @entity5 for @entity1 .

title: Postoperative radiotherapy is effective for XXXX but not for @entity1 : the Japanese Association for Research on the Thymus Database Study.

answer: @entity3


abstract: BACKGROUND: The efficacy of postoperative radiotherapy (PORT) for thymic @entity1 is still controversial. Using the Japanese Association for Research on the Thymus (JART) database, this study was aimed at clarifying the efficacy of PORT for @entity1 and @entity3 . METHODS: The JART database registered the records of 2835 @entity0 collected from 32 Japanese institutions from 1991 to 2010. @entity3 and @entity3 at stage II or III were extracted. The efficacy of PORT with respect to @entity5 ( @entity5 ) and @entity4 ( @entity4 ) was evaluated with the Kaplan-Meier method and Cox regression analysis. RESULTS: There were 1265 @entity0 in all: 155 @entity3 cases (12.3%) and 1110 @entity3 cases (87.7%). Eight hundred ninety-five (70.8%) were at stage II, and 370 (29.2%) were at stage III. Four hundred three cases (31.9%) underwent PORT. PORT for @entity1 was associated with increasing @entity5 (hazard ratio, 0.48; 95% confidence interval, 0.30-0.78; P =   .003) but was not associated with @entity4 (hazard ratio, 0.94; 95% confidence interval, 0.51-1.75; P =   .536). PORT for @entity2 was not associated with @entity5 or @entity4 (P =   .350). A subgroup analysis of stage III @entity3 showed no factor associated with the efficacy of PORT. CONCLUSIONS: In this study, PORT did not increase @entity5 or @entity4 for @entity2 but increased @entity5 for @entity1 .

title: Postoperative radiotherapy is effective for @entity3 but not for XXXX : the Japanese Association for Research on the Thymus Database Study.

answer: @entity1


abstract: UNASSIGNED: @entity5 ( @entity5 ) remains an important complication after total knee arthroplasty (TKA). Systemic thrombin generation starts perioperatively. @entity1 , characterized by a rise in @entity3 ( @entity3 ), initiates the coagulation cascade, but low-dose @entity2 can reduce post-TKA @entity3 levels. This double-blinded, randomized, placebo-controlled study enrolled 30 @entity0 undergoing unilateral TKA to assess the effect of perioperative @entity2 on serum prothrombin fragment (PF1.2), a marker of thrombin generation, and plasmin-alpha-2-antiplasmin complex (PAP), a marker of fibrinolysis. Study @entity0 received 100   mg of intravenous @entity4 2   h prior to surgery, and controls received normal saline. Blood samples, drawn pre-incision and at 4   h post tourniquet release, were assayed for PF1.2 and PAP. The study group had significantly lower mean PF1.2 at 4   h compared to controls (616        358   pMol/L vs. 936        332   pMol/L, p   =   0.037). The mean rise in PF1.2 in the control group was significantly greater compared to the study group (672        173   pMol/L vs. 350        211   pMol/L, p   <   0.001). Mean PAP was higher in the study group at 4   h (1639        823     g/L vs. 1087        536     g/L), but did not reach statistical significance (p   =   0.07). These results may have clinical implications in terms of postoperative @entity5 risk and management.    2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

title: Effects of XXXX on thrombogenic markers in @entity0 undergoing unilateral total knee arthroplasty: A prospective, double-blind, randomized controlled trial.

answer: @entity2


abstract: UNASSIGNED: @entity5 ( @entity5 ) remains an important complication after total knee arthroplasty (TKA). Systemic thrombin generation starts perioperatively. @entity1 , characterized by a rise in @entity3 ( @entity3 ), initiates the coagulation cascade, but low-dose @entity2 can reduce post-TKA @entity3 levels. This double-blinded, randomized, placebo-controlled study enrolled 30 @entity0 undergoing unilateral TKA to assess the effect of perioperative @entity2 on serum prothrombin fragment (PF1.2), a marker of thrombin generation, and plasmin-alpha-2-antiplasmin complex (PAP), a marker of fibrinolysis. Study @entity0 received 100   mg of intravenous @entity4 2   h prior to surgery, and controls received normal saline. Blood samples, drawn pre-incision and at 4   h post tourniquet release, were assayed for PF1.2 and PAP. The study group had significantly lower mean PF1.2 at 4   h compared to controls (616        358   pMol/L vs. 936        332   pMol/L, p   =   0.037). The mean rise in PF1.2 in the control group was significantly greater compared to the study group (672        173   pMol/L vs. 350        211   pMol/L, p   <   0.001). Mean PAP was higher in the study group at 4   h (1639        823     g/L vs. 1087        536     g/L), but did not reach statistical significance (p   =   0.07). These results may have clinical implications in terms of postoperative @entity5 risk and management.    2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

title: Effects of @entity2 on thrombogenic markers in XXXX undergoing unilateral total knee arthroplasty: A prospective, double-blind, randomized controlled trial.

answer: @entity0


abstract: INTRODUCTION: @entity3 ( @entity3 ) is a multi-factorial disease involving physiological as well as psychological factors. The aim of the study was to investigate a multidisciplinary inpatient treatment with emphasis on @entity2 therapy by @entity0 with @entity1 . MATERIALS AND METHODS: The study involved 104 @entity0 suffering from severely progressive @entity3 . A convenience sample and a prospective cohort design were used. The @entity0 were treated in an acute hospital focusing on @entity1 . One @entity0 group was treated with inclusion of @entity2 therapy and the other group without. The therapy density (number of performed therapies per @entity0 ) was determined for every @entity0 . Functional capacity measured by the Hannover functional status questionnaire (Funktionsfragebogen Hannover) and symptoms (von Zerssen complaint list) were analyzed for both groups on admission and on discharge. RESULTS: On admission, no significant difference could be established between control group (CG; multimodal without @entity2 ) and @entity2 group (HG; multimodal with @entity2 ) (functional capacity, P=0.936). Functional capacity improved for the CG and the HG. On discharge, there was a significant difference between the two groups (functional capacity, P=0.039). There were no significant differences in @entity3 symptoms between CG (mean 41.8) and HG (mean 41.8) on their admission to hospital (P=0.988). On discharge, there was a significant difference (P=0.024) between the two groups (HG, mean 30.6; CG, mean 36.6). The inpatient therapy of @entity0 with severely progressive @entity3 is characterized by a high frequency of therapy input. CONCLUSION: @entity3 , especially with severe progression and a high degree of chronification, demands a multidisciplinary approach. In addition to the use of complementary medical procedures, integration of @entity2 in the treatment process is a useful option.

title: XXXX with severe forms of progression in a multidisciplinary therapy setting with emphasis on @entity2 therapy - a prospective controlled study.

answer: @entity3


abstract: INTRODUCTION: @entity3 ( @entity3 ) is a multi-factorial disease involving physiological as well as psychological factors. The aim of the study was to investigate a multidisciplinary inpatient treatment with emphasis on @entity2 therapy by @entity0 with @entity1 . MATERIALS AND METHODS: The study involved 104 @entity0 suffering from severely progressive @entity3 . A convenience sample and a prospective cohort design were used. The @entity0 were treated in an acute hospital focusing on @entity1 . One @entity0 group was treated with inclusion of @entity2 therapy and the other group without. The therapy density (number of performed therapies per @entity0 ) was determined for every @entity0 . Functional capacity measured by the Hannover functional status questionnaire (Funktionsfragebogen Hannover) and symptoms (von Zerssen complaint list) were analyzed for both groups on admission and on discharge. RESULTS: On admission, no significant difference could be established between control group (CG; multimodal without @entity2 ) and @entity2 group (HG; multimodal with @entity2 ) (functional capacity, P=0.936). Functional capacity improved for the CG and the HG. On discharge, there was a significant difference between the two groups (functional capacity, P=0.039). There were no significant differences in @entity3 symptoms between CG (mean 41.8) and HG (mean 41.8) on their admission to hospital (P=0.988). On discharge, there was a significant difference (P=0.024) between the two groups (HG, mean 30.6; CG, mean 36.6). The inpatient therapy of @entity0 with severely progressive @entity3 is characterized by a high frequency of therapy input. CONCLUSION: @entity3 , especially with severe progression and a high degree of chronification, demands a multidisciplinary approach. In addition to the use of complementary medical procedures, integration of @entity2 in the treatment process is a useful option.

title: @entity3 with severe forms of progression in a multidisciplinary therapy setting with emphasis on XXXX therapy - a prospective controlled study.

answer: @entity2


abstract: OBJECTIVE: Our objective was to understand the relationship between optimal diabetes control, as defined by @entity4 ( @entity4 ), and adverse health outcomes including @entity3 ( @entity3 ) visits, hospitalizations, 30-day rehospitalization, @entity5 ( @entity5 ) stay, and mortality. @entity0 AND METHODS: In 2009, we conducted a retrospective cohort study of empaneled Employee and @entity4 @entity0 with @entity1 . We followed @entity0 from 1 September 2009 until 30 June 2011 for hospitalization and until 5 January 2014 for mortality. Optimal control of @entity1 was defined as achieving the following three measures: low-density lipoprotein (LDL) @entity2 <100 mg/mL, blood pressure <140/90 mmHg, and hemoglobin A1c <8%. Using the electronic medical record, we assessed hospitalizations, @entity3 visits, @entity5 stays, 30-day rehospitalizations, and mortality. The chi-square or Wilcoxon rank-sum tests were used to compare those with and without optimal control. We used Cox proportional hazard models to estimate the associations between optimal @entity1 status and each outcome. RESULTS: We identified 5,731 empaneled @entity0 with @entity1 ; 2,842 (49.6%) were in the optimal control category. After adjustment, we observed that non-optimally controlled @entity0 had higher risks for hospitalization (hazard ratio [HR] 1.11; 95% confidence interval [CI] 1.00-1.23), @entity3 visits (HR 1.15; 95% CI 1.06-1.25), and mortality (HR 1.29; 95% CI 1.09-1.53) than @entity1 @entity0 with optimal control. No differences were observed in @entity5 stay or 30-day rehospitalization. CONCLUSION: @entity1 @entity0 without optimal control had higher risks of adverse health outcomes than those with optimal control. @entity0 with optimal control defined by the @entity4 were associated with decreased morbidity and mortality.

title: Health outcomes in @entity1 measured with XXXX quality metrics.

answer: @entity4


abstract: OBJECTIVE: Our objective was to understand the relationship between optimal diabetes control, as defined by @entity4 ( @entity4 ), and adverse health outcomes including @entity3 ( @entity3 ) visits, hospitalizations, 30-day rehospitalization, @entity5 ( @entity5 ) stay, and mortality. @entity0 AND METHODS: In 2009, we conducted a retrospective cohort study of empaneled Employee and @entity4 @entity0 with @entity1 . We followed @entity0 from 1 September 2009 until 30 June 2011 for hospitalization and until 5 January 2014 for mortality. Optimal control of @entity1 was defined as achieving the following three measures: low-density lipoprotein (LDL) @entity2 <100 mg/mL, blood pressure <140/90 mmHg, and hemoglobin A1c <8%. Using the electronic medical record, we assessed hospitalizations, @entity3 visits, @entity5 stays, 30-day rehospitalizations, and mortality. The chi-square or Wilcoxon rank-sum tests were used to compare those with and without optimal control. We used Cox proportional hazard models to estimate the associations between optimal @entity1 status and each outcome. RESULTS: We identified 5,731 empaneled @entity0 with @entity1 ; 2,842 (49.6%) were in the optimal control category. After adjustment, we observed that non-optimally controlled @entity0 had higher risks for hospitalization (hazard ratio [HR] 1.11; 95% confidence interval [CI] 1.00-1.23), @entity3 visits (HR 1.15; 95% CI 1.06-1.25), and mortality (HR 1.29; 95% CI 1.09-1.53) than @entity1 @entity0 with optimal control. No differences were observed in @entity5 stay or 30-day rehospitalization. CONCLUSION: @entity1 @entity0 without optimal control had higher risks of adverse health outcomes than those with optimal control. @entity0 with optimal control defined by the @entity4 were associated with decreased morbidity and mortality.

title: Health outcomes in XXXX measured with @entity4 quality metrics.

answer: @entity1


abstract: PURPOSE: We investigated the effect of Katsura-uri (Japanese pickling @entity6 ; @entity6 . conomon) on energy metabolism during exercise in @entity0 and animal studies. METHODS: Eight healthy @entity0 (mean age, 21.4      0.7  years) participated in a single-blind, crossover study. Thirty minutes after ingesting the Katsura-uri drink or placebo drink, they exercised on a cycle ergometer at 40% maximal heart rate for 30  min. Respiratory gas analysis was performed during exercise to examine @entity2 consumption and substrate utilization. Blood biochemical parameters were evaluated during exercise. In the animal study, the effect of @entity8 ( @entity7 ), a Katsura-uri derived component was examined in @entity1 . Immediately after running at 25  m/min for 30  min, biochemical parameters in the hind limb muscle and blood of @entity1 were measured. RESULTS: @entity2 consumption during exercise was higher in the Katsura-uri condition (19.8      3.5  mL/kg/min) than the placebo condition (18.6      3.0  mL/kg/min) (P  <  0.05). The elevation of blood @entity4 was lower in the Katsura-uri condition (1.7      0.4  mM) than the placebo condition (2.2      0.6  mM) 15  min after beginning exercise (P  <  0.05). There was a higher positive correlation between @entity4 concentration and @entity5 oxidation during exercise in the Katsura-uri condition (R(2)  =  0.86) compared to the placebo condition (R(2)  =  0.47). The decrease in intermuscular pH and the increase in blood @entity4 following exercise were prevented by @entity7 supplementation (250  ppm) with significant differences in the @entity7 -supplemented group compared to the control group. CONCLUSIONS: These results suggest that the ingestion of Katsura-uri and/or @entity7 improves @entity3 metabolism and acidification in skeletal muscles during exercise in @entity0 and animal studies.

title: The effect of Katsura-uri (Japanese pickling XXXX , @entity6 . conomon) and its derived ingredient @entity8 on energy metabolism during aerobic exercise.

answer: @entity6


abstract: PURPOSE: We investigated the effect of Katsura-uri (Japanese pickling @entity6 ; @entity6 . conomon) on energy metabolism during exercise in @entity0 and animal studies. METHODS: Eight healthy @entity0 (mean age, 21.4      0.7  years) participated in a single-blind, crossover study. Thirty minutes after ingesting the Katsura-uri drink or placebo drink, they exercised on a cycle ergometer at 40% maximal heart rate for 30  min. Respiratory gas analysis was performed during exercise to examine @entity2 consumption and substrate utilization. Blood biochemical parameters were evaluated during exercise. In the animal study, the effect of @entity8 ( @entity7 ), a Katsura-uri derived component was examined in @entity1 . Immediately after running at 25  m/min for 30  min, biochemical parameters in the hind limb muscle and blood of @entity1 were measured. RESULTS: @entity2 consumption during exercise was higher in the Katsura-uri condition (19.8      3.5  mL/kg/min) than the placebo condition (18.6      3.0  mL/kg/min) (P  <  0.05). The elevation of blood @entity4 was lower in the Katsura-uri condition (1.7      0.4  mM) than the placebo condition (2.2      0.6  mM) 15  min after beginning exercise (P  <  0.05). There was a higher positive correlation between @entity4 concentration and @entity5 oxidation during exercise in the Katsura-uri condition (R(2)  =  0.86) compared to the placebo condition (R(2)  =  0.47). The decrease in intermuscular pH and the increase in blood @entity4 following exercise were prevented by @entity7 supplementation (250  ppm) with significant differences in the @entity7 -supplemented group compared to the control group. CONCLUSIONS: These results suggest that the ingestion of Katsura-uri and/or @entity7 improves @entity3 metabolism and acidification in skeletal muscles during exercise in @entity0 and animal studies.

title: The effect of Katsura-uri (Japanese pickling @entity6 , XXXX . conomon) and its derived ingredient @entity8 on energy metabolism during aerobic exercise.

answer: @entity6


abstract: PURPOSE: We investigated the effect of Katsura-uri (Japanese pickling @entity6 ; @entity6 . conomon) on energy metabolism during exercise in @entity0 and animal studies. METHODS: Eight healthy @entity0 (mean age, 21.4      0.7  years) participated in a single-blind, crossover study. Thirty minutes after ingesting the Katsura-uri drink or placebo drink, they exercised on a cycle ergometer at 40% maximal heart rate for 30  min. Respiratory gas analysis was performed during exercise to examine @entity2 consumption and substrate utilization. Blood biochemical parameters were evaluated during exercise. In the animal study, the effect of @entity8 ( @entity7 ), a Katsura-uri derived component was examined in @entity1 . Immediately after running at 25  m/min for 30  min, biochemical parameters in the hind limb muscle and blood of @entity1 were measured. RESULTS: @entity2 consumption during exercise was higher in the Katsura-uri condition (19.8      3.5  mL/kg/min) than the placebo condition (18.6      3.0  mL/kg/min) (P  <  0.05). The elevation of blood @entity4 was lower in the Katsura-uri condition (1.7      0.4  mM) than the placebo condition (2.2      0.6  mM) 15  min after beginning exercise (P  <  0.05). There was a higher positive correlation between @entity4 concentration and @entity5 oxidation during exercise in the Katsura-uri condition (R(2)  =  0.86) compared to the placebo condition (R(2)  =  0.47). The decrease in intermuscular pH and the increase in blood @entity4 following exercise were prevented by @entity7 supplementation (250  ppm) with significant differences in the @entity7 -supplemented group compared to the control group. CONCLUSIONS: These results suggest that the ingestion of Katsura-uri and/or @entity7 improves @entity3 metabolism and acidification in skeletal muscles during exercise in @entity0 and animal studies.

title: The effect of Katsura-uri (Japanese pickling @entity6 , @entity6 . conomon) and its derived ingredient XXXX on energy metabolism during aerobic exercise.

answer: @entity8


abstract: BACKGROUND AND OBJECTIVES: Several clinical studies suggest that interstitial photodynamic therapy (I-PDT) may benefit @entity0 with locally advanced @entity2 (LAHNC). For I-PDT, the therapeutic light is delivered through optical fibers inserted into the target @entity1 . The complex anatomy of the head and neck requires careful planning of fiber insertions. Often the fibers' location and @entity1 optical properties may vary from the original plan therefore pretreatment planning needs near real-time updating to account for any changes. The purpose of this work was to develop a @entity3 ( @entity3 ) approach for near real-time simulation of light propagation in LAHNC. METHODS: Our previously developed @entity3 for modeling light propagation in skin tissue was modified to simulate light propagation from interstitial optical fibers. The modified model was validated by comparing the calculations with measurements in a phantom mimicking @entity1 optical properties. We investigated the impact of mesh element size and growth rate on the computation time, and defined optimal settings for the @entity3 . We demonstrated how the optimized @entity3 can be used for simulating light propagation in two cases of LAHNC amenable to I-PDT, as proof-of-concept. RESULTS: The modified @entity3 was in agreement with the measurements (P   =   0.0271). The optimal maximum mesh size and growth rate were 0.005-0.02   m and 2-2.5   m/m, respectively. Using these settings the computation time for simulating light propagation in LAHNC was reduced from 25.9 to 3.7   minutes in one case, and 10.1 to 4   minutes in another case. There were minor differences (1.62%, 1.13%) between the radiant exposures calculated with either mesh in both cases. CONCLUSIONS: Our @entity3 approach can be used to model light propagation from diffused optical fibers in complex heterogeneous geometries representing LAHNC. There is a range of maximum element size (MES) and maximum element growth rate (MEGR) that can be used to minimize the computation time of the @entity3 to 4   minutes. Lasers Surg. Med. 47:60-67, 2015.    2015 Wiley Periodicals, Inc.

title: A new finite element approach for near real-time simulation of light propagation in locally advanced XXXX .

answer: @entity2


abstract: PURPOSE: We were going to access the effect of @entity2 ( @entity2 ) on post-thrombotic syndrome (PTS) and the long term effects of iliac vein stenting in acute iliofemoral @entity1 (IFDVT). MATERIALS AND METHODS: Fifty-six limbs in fifty-one @entity0 (46 unilateral, 5 bilateral) were included from November 2001 through December 2007. @entity0 were classified based on the method of treatment: with stent implantation (n=37) and without stent implantation (n=19). The Villalta scale was chosen to assess for severity of PTS. The validated outcome measures were compared between the treatment groups. Statistical analysis was estimated according to the Kaplan-Meier test and Pearson chi-square test. RESULTS: Mean age was 57  13 years (range, 27-76 years). Mean follow up duration was 56  12 months (range, 24-144 months). Overall 5-year primary patency rate was 66.1% (77.8% in the stenting group and 42.1% in the non-stenting group) and showed statistically significant difference between the two groups (P=0.02). The recurrence rate of @entity1 was 10/37 (27.1%) in the stenting group and 11/19 (57.9%) in the non-stenting group, respectively, which showed statistically significant difference between the two groups (P=0.024). Overall incidence of mild PTS was 8/30 (26.7%): 4/13 (30.8%) in the stenting group and 4/17 (23.5%) in the non-stenting group. None of the other factors showed statistically significant difference between the groups. CONCLUSION: Long term results of @entity2 in IFDVT were acceptable, and stent implantation to the iliac segment seems to have a good effect on the long term results. Therefore @entity2 with simultaneous stenting is recommended to improve long term results of IFDVT, if indicated.

title: Long-Term Results of Catheter-Directed Thrombolysis Combined with Iliac Vein Stenting for Iliofemoral XXXX .

answer: @entity1


abstract: UNASSIGNED: We investigated the treatment of @entity2 with @entity4 laser as an alternative therapy to surgical excision. The charts of 73 @entity0 with 95 lesions treated with @entity4 laser photocoagulation were reviewed retrospectively. In all @entity0 , the procedure was performed for cosmetic reasons. The laser spot size ranged from 50 to 200   m, the power varied from 300 to 700  mW, and the exposure time ranged between 0.1 and 0.2  s. The lesions were mostly located on the upper eyelid (66  %); the lid margin was involved in 30 cases. The mean follow-up time was 7.2        3.5  months (range 3-15  months). A histopathological diagnosis was confirmed for 81 lesions (85.3  %). All @entity0 were satisfied with the cosmetic result. No @entity5 occurred, and none of the @entity0 complained of @entity3 during laser application. All wounds epithelialized in 3-4  weeks with skin that appeared normal. @entity6 of the treated areas were observed in three cases. No recurrence occurred during the follow-up period. @entity4 laser-assisted benign eyelid @entity1 excision is a useful, cheap, accessible, and well-tolerated alternative to traditional surgery.

title: XXXX laser-assisted treatment of @entity2 .

answer: @entity4


abstract: UNASSIGNED: We investigated the treatment of @entity2 with @entity4 laser as an alternative therapy to surgical excision. The charts of 73 @entity0 with 95 lesions treated with @entity4 laser photocoagulation were reviewed retrospectively. In all @entity0 , the procedure was performed for cosmetic reasons. The laser spot size ranged from 50 to 200   m, the power varied from 300 to 700  mW, and the exposure time ranged between 0.1 and 0.2  s. The lesions were mostly located on the upper eyelid (66  %); the lid margin was involved in 30 cases. The mean follow-up time was 7.2        3.5  months (range 3-15  months). A histopathological diagnosis was confirmed for 81 lesions (85.3  %). All @entity0 were satisfied with the cosmetic result. No @entity5 occurred, and none of the @entity0 complained of @entity3 during laser application. All wounds epithelialized in 3-4  weeks with skin that appeared normal. @entity6 of the treated areas were observed in three cases. No recurrence occurred during the follow-up period. @entity4 laser-assisted benign eyelid @entity1 excision is a useful, cheap, accessible, and well-tolerated alternative to traditional surgery.

title: @entity4 laser-assisted treatment of XXXX .

answer: @entity2


abstract: Nasal transepithelial electrical @entity1 ( @entity1 ) was estimated in vivo in normal @entity0 subjects. The @entity1 between a bridge perfused with Ringer's solution placed on the nasal mucosal surface and a reference electrode in a subcutaneous space was recorded. The magnitude of the @entity1 depended upon the region of the nasal cavity touched by the exploring bridge. The @entity1 values ranged from -4 mV (lumen negative) on the anterior tip of the inferior turbinate to approximately -30 mV on the inferior surface of the turbinate. Biopsies of the anterior turbinate were characterized by squamous epithelial cells, whereas ciliated cells dominated the epithelium from regions of higher @entity1 . Epithelial abrasion abolished @entity1 . No differences in @entity1 were noted between the left and right nasal cavities, and repetitive measurements of @entity1 at the same site yielded comparable values. No differences in nasal @entity1 were noted between young male or female subjects but @entity1 declined as a function of age. @entity4 (10(-4)M) and @entity3 (10(-1)M) reduced @entity1 (-59% and -30%, respectively), whereas @entity2 (5 X 10(-5)M) raised @entity1 (+29%). We concluded that nasal @entity1 can be accurately measured in vivo in @entity0 , and that measurements of nasal bioelectric properties may serve as a relatively noninvasive index of respiratory epithelial function.

title: Measurements of nasal transepithelial electric potential differences in normal XXXX subjects in vivo.

answer: @entity0


abstract: OBJECTIVES: To describe the clinical characteristics, diagnostic methods, treatment modalities, and complications, and identify the mortality risk factors, of @entity0 with short-term persistent pulmonary @entity1 of the newborn (PPHN). METHODS: The clinical data of @entity0 diagnosed with PPHN at Hat Yai Hospital from January 2010 to February 2014 were retrospectively reviewed. Cox proportional hazard regression analysis was performed to assess factors associated with mortality. RESULTS: The records of 119 @entity0 were analyzed. Of these, 47 died giving an in-hospital mortality rate of 39.5%. The prevalence of PPHN (based on inborn births) was 2.8 per 1000 live births. The mean gestational age and birth weight were 39.1        1.6 weeks and 3044        563   g, respectively. Multivariate Cox regression analysis indicated that pneumothorax [adjusted hazard ratio (HR)   =   2.07 (95% CI 1.09-3.93)] and @entity3 [adjusted HR   =   2.99 (95% CI 1.59-5.61)] were factors associated independently with an increased risk for @entity2 , while @entity0 who received total parenteral nutrition [adjusted HR   =   0.22 (95% CI 0.10-0.50)] had lower mortality. CONCLUSION: A high mortality rate of PPHN was observed in this study. Significantly higher mortality was noted in @entity0 complicated with pneumothorax and @entity3 .

title: @entity3 and pneumothorax are risk factors for mortality in persistent pulmonary XXXX of the newborn in Thai neonates.

answer: @entity1


abstract: OBJECTIVES: To describe the clinical characteristics, diagnostic methods, treatment modalities, and complications, and identify the mortality risk factors, of @entity0 with short-term persistent pulmonary @entity1 of the newborn (PPHN). METHODS: The clinical data of @entity0 diagnosed with PPHN at Hat Yai Hospital from January 2010 to February 2014 were retrospectively reviewed. Cox proportional hazard regression analysis was performed to assess factors associated with mortality. RESULTS: The records of 119 @entity0 were analyzed. Of these, 47 died giving an in-hospital mortality rate of 39.5%. The prevalence of PPHN (based on inborn births) was 2.8 per 1000 live births. The mean gestational age and birth weight were 39.1        1.6 weeks and 3044        563   g, respectively. Multivariate Cox regression analysis indicated that pneumothorax [adjusted hazard ratio (HR)   =   2.07 (95% CI 1.09-3.93)] and @entity3 [adjusted HR   =   2.99 (95% CI 1.59-5.61)] were factors associated independently with an increased risk for @entity2 , while @entity0 who received total parenteral nutrition [adjusted HR   =   0.22 (95% CI 0.10-0.50)] had lower mortality. CONCLUSION: A high mortality rate of PPHN was observed in this study. Significantly higher mortality was noted in @entity0 complicated with pneumothorax and @entity3 .

title: XXXX and pneumothorax are risk factors for mortality in persistent pulmonary @entity1 of the newborn in Thai neonates.

answer: @entity3


abstract: OBJECTIVE: To compare rates of clinical pregnancy (CPR) and live birth (LBR) following embryo transfer (ET) performed by reproductive endocrinology and @entity2 (REI) fellows before and after a prolonged lapse in clinical training due to an 18-month @entity3 . DESIGN: Retrospective cohort study. SETTING: Not applicable. @entity0 (S): All @entity0 undergoing @entity1 ( @entity1 ) and @entity1 -intracytoplasmic sperm injection (ICSI) cycles with ET performed by REI fellows from August 2003 to July  2012. INTERVENTION: Eighteen-month lapse in clinical training of REI fellows. MAIN OUTCOME MEASURE(S): CPR and LBR before and after the lapse in clinical training were calculated and compared per fellow and as a composite group. Alternating logistic regression models were used to calculate the odds of clinical pregnancy and live birth following transfers performed before and after the lapse in training. RESULT(S): Unadjusted odds of clinical pregnancy and live birth were similar between the two time periods both for individual fellows and for the composite group. Alternate logistic regression analysis revealed no significant difference in CPR (odds ratio [OR] 0.94, 95% confidence interval [CI] 0.83-1.07) or LBR (OR 1.05, 95% CI 0.94-1.18) after the lapse in training compared with before. CONCLUSION(S): A @entity3 is common in REI fellowship training programs. This prolonged departure from clinical training does not appear to negatively affect pregnancy outcome following fellow ET.

title: Lapse in embryo transfer training does not negatively affect clinical  pregnancy rates for reproductive endocrinology and XXXX fellows.

answer: @entity2


abstract: BACKGROUND: Clinical characteristics and optimal treatment strategies for spindle cell/sclerosing @entity7 (ssRMS) have not been well established because of its rarity. PROCEDURE: Retrospective re-evaluation of @entity5 specimens (1997-2014) identified 16 ssRMSs (median age 20 years, range 7-39 years). Clinicopathological features, clinical course, and outcome were analyzed. RESULTS: Primary disease sites were the head and neck (10 cases) and other regions (6 cases). Nine cases were at Intergroup @entity7 Study preoperative stage 3. The @entity2 were >5   cm in 13 cases. Two @entity0 had lymph node @entity1 , but none had distant @entity1 at presentation. At follow-up (median period 39 months, range 4.6-201), seven @entity0 were alive without disease. Among nine @entity0 treated with the @entity8 , @entity9 , and @entity6 (VAC) regimen, five responded well, with four surviving free of disease. Among ten @entity0 with recurrent or progressive disease, three experienced local recurrence, four had distant @entity1 , and three had both. None exhibited @entity4 . Eight of the ten @entity0 died in median time from relapse to @entity3 of 18 months (range 11-56). CONCLUSIONS: Although most ssRMSs present as a bulky @entity2 , nodal or distant @entity1 are rare at presentation. ssRMSs initially show good response to VAC, but >50% of @entity2 recur or progress; these data suggest a worse prognosis of ssRMS compared to the pediatric embryonal variant. As relapse typically occurs as local or distant solitary lesion without @entity4 , localized treatment combined with chemotherapy would contribute to improve the prognosis of recurrent ssRMS. Pediatr @entity2    2014 Wiley Periodicals, Inc.

title: Clinicopathologic analysis of spindle cell/sclerosing XXXX .

answer: @entity7


abstract: UNASSIGNED: @entity0 with @entity2 ( @entity2 ) are commonly seen by physiotherapists and there is growing evidence to support a physical rehabilitation approach. There are, however, few descriptions in the literature of the content of successful physiotherapy treatment. This prospective cohort study reports the practicalities and outcomes of a pilot 5-day physiotherapy programme. @entity0 were referred from a specialist @entity1 clinic. The treatment consisted of education and movement retraining, with a long-term self-management focus. Education and movement retraining was based on a pathophysiological model for @entity2 that stresses the importance of self-focussed attention and illness belief. @entity0 were assessed at baseline, end of treatment and 3-month follow-up. 47 @entity0 completed the programme, mean symptom duration was 5.5  years, 64  % were unemployed due to ill health. At the end of treatment, 65  % rated their symptoms as "very much improved" or "much improved", this reduced to 55  % at 3  months. At follow-up, there was a significant improvement in physical domains of the SF-36, Berg Balance Scale and 10 Metre Timed Walk. Measures of mental health did not change. This prospective cohort study adds to the growing evidence that supports the use of specialist physiotherapy treatment for @entity2 . Improvements here were made despite the cohort having characteristics associated with poor prognosis. We argue that specific treatment techniques are important and have the potential to improve physical function, quality of life and may prove to be a cost-effective treatment for selected @entity0 with @entity2 .

title: Outcomes of a 5-day physiotherapy programme for functional (psychogenic) XXXX .

answer: @entity2


abstract: UNASSIGNED: Stress @entity2 of the first rib on the dominant throwing side are well-described in baseball pitchers; however, lower @entity2 are not commonly recognized. While common in other sports such as rowing, there is scant literature on these injuries in baseball. Intercostal muscle strains are commonly diagnosed in baseball pitchers and have a nearly identical presentation but also a highly variable healing time. The diagnosis of a rib stress @entity2 can predict a more protracted recovery. This case series presents two collegiate baseball pitchers on one team during the same season who were originally diagnosed with @entity1 , which following magnetic resonance imaging (MRI) were found to have actually sustained lower thoracic rib @entity4 . The first sustained a stress @entity2 of the posterior aspect of the right 8th rib on the dominant arm side, while the second presented with a left-sided 10th rib stress @entity2 on the nondominant arm side. In both cases, MRI was used to visualize the @entity2 as plain radiographs are insensitive and commonly negative early in @entity0 presentation. @entity0 were treated with activity modification, and symptomatic management for 4-6 weeks with a graduated return to throwing and competition by 8-10 weeks. The repetitive high stresses incurred by pitching may cause either dominant or nondominant rib @entity4 and this should be included in the differential diagnosis of @entity3 in throwers. It is especially important that athletic trainers and team physicians consider this diagnosis, as @entity2 may have a protracted course and delayed return to play. Additionally, using the appropriate imaging techniques to establish an accurate diagnosis can help inform return-to-play decisions, which have important practical applications in baseball, such as roster management and eligibility.

title: Lower thoracic rib XXXX in baseball pitchers.

answer: @entity4


abstract: PURPOSE: To evaluate the efficacy of a knowledge-based iterative model reconstruction (IMR) algorithm for reducing image noise in ultralow-dose (ULD) CT for @entity2 . MATERIALS AND METHODS: A total of 103 @entity0 diagnosed with urinary stones (n = 276) were enrolled. Regular dose (RD) scans (120 kV and 150 mAs, maximal tube current in dose modulation) were reconstructed using filtered back-projection ( @entity4 , RD- @entity4 ), and ULD scans (100 kV and 20 mAs, fixed tube current) were reconstructed with @entity4 (ULD- @entity4 ), statistical iterative reconstruction (IR; ULD-iDose), and a knowledge-based IMR algorithm (ULD-IMR). Prospective interpretations of the two scans were performed with respect to radiation dose, objective image noise, and subjective assessment. The subjective assessment was also evaluated with regard to each @entity0 's body mass index (BMI, < 25 or >=  25 kg/m(2)). Using RD CT (RD- @entity4 ) as the reference standard, two reviewers assessed the diagnostic performance and inter-observer agreement for ULD-IMR. RESULT: The average effective doses with RD CT and ULD CT were 8.31 and 0.68 @entity3 , respectively, and the average radiation dose reduction rate was 91.82% (p < 0.01). The lowest objective image noise was observed with ULD-IMR (p < 0.01). Subjective assessment in ULD-IMR was comparable to that of RD- @entity4 , although RD- @entity4 remained statistically superior. For BMI, there was a statistically significant difference in subjective image quality between the normal (4.7    0.54) and overweight or @entity1 groups (4.2    0.5) (p < 0.05). The ULD-IMR showed a greater than 75% concordant rate in overall stones and 100% in ureter stones larger than 3 mm. However, for stones <3 mm, neither reviewer had a good detection rate (45.5% and 56.9% for the general and genitourinary radiologist, respectively). Inter-observer agreement was almost perfect (k = 0.82). CONCLUSION: Despite a significant radiation dose reduction, ULD-IMR images were comparable in image quality and noise to RD- @entity4 images. Furthermore, the diagnostic performance of the ULD non-enhanced CT protocol was comparable to that of the RD scan for diagnosing urinary stones larger than 3 mm.

title: Knowledge-based iterative model reconstruction (IMR) algorithm in ultralow-dose CT for evaluation of XXXX : evaluation of radiation dose reduction, image quality, and diagnostic performance.

answer: @entity2


abstract: OBJECTIVE: Evaluation of the impact of sequential chemoradiotherapy in high risk @entity2 ( @entity2 ). METHODS: Two hundred fifty-four @entity0 with stage IB grade 3, II and III @entity2 (2009 FIGO staging), were included in this retrospective study. RESULTS: Stage I, II, and III was 24%, 28.7%, and 47.3%, respectively. Grade 3 @entity1 was 53.2% and 71.3% had deep myometrial invasion. One hundred sixty-five @entity0 (65%) underwent pelvic (+/- aortic) lymphadenectomy and 58 (22.8%) had nodal metastases. Ninety-eight @entity0 (38.6%) underwent radiotherapy, 59 (23.2%) chemotherapy, 42 (16.5%) sequential chemoradiotherapy, and 55 (21.7%) were only observed. After a median follow-up of 101 months, 78 @entity0 (30.7%) relapsed and 91 @entity0 (35.8%) died. Sequential chemoradiotherapy improved survival rates in @entity0 who did not undergo nodal evaluation (disease-free survival [DFS], p=0.040; @entity3 [ @entity3 ], p=0.024) or pelvic (+/- aortic) lymphadenectomy (DFS, p=0.008; @entity3 , p=0.021). Sequential chemoradiotherapy improved both DFS (p=0.015) and @entity3 (p=0.014) in stage III, while only a trend was found for DFS (p=0.210) and @entity3 (p=0.102) in stage I-II @entity2 . In the multivariate analysis, only age ( <= 65 years) and sequential chemoradiotherapy were statistically related to the prognosis. CONCLUSION: Sequential chemoradiotherapy improves survival rates in high risk @entity2 compared with chemotherapy or radiotherapy alone, in particular in stage III.

title: Adjuvant sequential chemo and radiotherapy improves the oncological outcome in high risk XXXX .

answer: @entity2


abstract: BACKGROUND: Slow transit constipation (STC) is associated with @entity1 . The underlying cause(s) of the abnormalities remain poorly defined. In health, utilizing high resolution fiber-optic manometry, we have described a distal colonic propagating motor pattern with a slow wave frequency of 2-6 cycles per minute (cpm). A high calorie meal caused a rapid and significant increase in this activity, suggesting the intrinsic slow wave activity could be mediated by extrinsic neural input. Utilizing the same protocol our aim was to characterize colonic meal response STC @entity0 . METHODS: A fiber-optic manometry catheter (72 sensors at 1  cm intervals) was colonoscopically placed with the tip clipped at the ascending or transverse colon, in 14 @entity0 with scintigraphically confirmed STC. Manometric recordings were taken, for 2  h pre and post a 700  kCal meal. Data were compared to 12 healthy adults. KEY RESULTS: Prior to and/or after the meal the cyclic propagating motor pattern was identified in 13 of 14 @entity0 . However, the meal, did not increase the cyclic motor pattern (preprandial 7.4      7.6 vs postprandial 8.3      4.5 per/2  h), this is in contrast to the dramatic increase observed in health (8.3      13.3 vs 59.1      89.0 per/2  h; p  <  0.001). CONCLUSIONS _ INFERENCES: In @entity0 with STC a meal fails to induce the normal increase in the distal colonic cyclic propagating motor patterns. We propose that these data may indicate that the normal extrinsic parasympathetic inputs to the colon are attenuated in these @entity0 .

title: XXXX in slow transit constipation defined by high resolution, fibre-optic manometry.

answer: @entity1


abstract: BACKGROUND:: Obesity is associated with intestinal-specific @entity5 . Nonetheless, a specific role of @entity1 in the etiology of @entity2 is unclear. METHODS:: We conducted a prospective cohort study of U.S. @entity0 enrolled in 1989 in the Nurses' Health Study II. At baseline, we collected information on height, weight, waist and hip circumference, weight at age 18, and body shape at age 20. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs). RESULTS:: Among 111,498 @entity0 (median age, 35 yr), we documented 153 cases of @entity3 ( @entity3 ) and 229 cases of @entity4 ( @entity4 ) more than 18 years of follow-up, encompassing 2,028,769 @entity0 -years. Compared with @entity0 with normal BMI, the multivariate-adjusted hazard ratios of @entity3 were 2.33 (95% CI, 1.15-4.69) for @entity1 @entity0 at age 18 and 1.58 (95% CI, 1.01-2.47) for @entity1 @entity0 at baseline. Increasing weight gain between age 18 and baseline was associated with increased risk of @entity3 (Ptrend = 0.04). Adolescent body habitus was also associated with risk of @entity3 with a multivariate-adjusted hazard ratio of @entity3 of 1.63 (95% CI, 1.07-2.50) for @entity0 with @entity1 compared with @entity0 with a thin/slender body shape. We did not observe a significant association between any of these anthropometric measures and risk of @entity4 . CONCLUSIONS:: In a large prospective cohort of U.S. @entity0 , measures of adiposity were associated with an increased risk of @entity3 but not @entity4 . Additional studies are needed to elucidate the biological mechanisms by which excess adiposity may increase the risk of @entity3 .

title: Measures of Obesity and Risk of @entity3 and XXXX .

answer: @entity4


abstract: BACKGROUND:: Obesity is associated with intestinal-specific @entity5 . Nonetheless, a specific role of @entity1 in the etiology of @entity2 is unclear. METHODS:: We conducted a prospective cohort study of U.S. @entity0 enrolled in 1989 in the Nurses' Health Study II. At baseline, we collected information on height, weight, waist and hip circumference, weight at age 18, and body shape at age 20. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs). RESULTS:: Among 111,498 @entity0 (median age, 35 yr), we documented 153 cases of @entity3 ( @entity3 ) and 229 cases of @entity4 ( @entity4 ) more than 18 years of follow-up, encompassing 2,028,769 @entity0 -years. Compared with @entity0 with normal BMI, the multivariate-adjusted hazard ratios of @entity3 were 2.33 (95% CI, 1.15-4.69) for @entity1 @entity0 at age 18 and 1.58 (95% CI, 1.01-2.47) for @entity1 @entity0 at baseline. Increasing weight gain between age 18 and baseline was associated with increased risk of @entity3 (Ptrend = 0.04). Adolescent body habitus was also associated with risk of @entity3 with a multivariate-adjusted hazard ratio of @entity3 of 1.63 (95% CI, 1.07-2.50) for @entity0 with @entity1 compared with @entity0 with a thin/slender body shape. We did not observe a significant association between any of these anthropometric measures and risk of @entity4 . CONCLUSIONS:: In a large prospective cohort of U.S. @entity0 , measures of adiposity were associated with an increased risk of @entity3 but not @entity4 . Additional studies are needed to elucidate the biological mechanisms by which excess adiposity may increase the risk of @entity3 .

title: Measures of Obesity and Risk of XXXX and @entity4 .

answer: @entity3


abstract: OBJECTIVES: @entity1 is often one of the causes to make treatments for M  ni  re's disease more difficult. The aim in the present study is to examine ratios of the @entity7 and @entity3 in @entity0 with intractable M  ni  re's disease and also relationships between the ratios and surgical results after endolymphatic sac drainage with large doses of @entity2 . METHODS: Between 1998 and 2009, we enrolled 263 intractable M  ni  re's @entity0 and divided into two groups, 207 in surgical group and 56 in non-surgical group. We used the Cornell Medical Index (CMI) and the @entity3 ( @entity3 ) at the diagnosis in our hospital to evaluate their @entity5 before treatments. CMI domains III and IV were defined as @entity7 and @entity3 scores more than 40 as @entity3 as a matter of convenience. Two years as well as seven years after surgery, @entity0 with vertigo zero/month and hearing change>-10dB were evaluated in success group and the others in non-success group. RESULTS: @entity7 and @entity3 were diagnosed in approximately 40% and 60%, respectively, of intractable M  ni  re's disease. Our results showed that surgical treatment significantly improved vertigo suppression and @entity4 in @entity0 with no @entity6 compared with those exhibiting @entity6 both in surgical and non-surgical groups. Furthermore, surgical results in cases with @entity1 were superior to non-surgical results in cases without mental distress. CONCLUSIONS: All taken together, psychological supports could be necessary for improving results both in the surgical and non-surgical treatments for @entity0 with intractable M  ni  re's disease. Some cases with intractable M  ni  re's disease should really require additional surgical treatments even after psychological therapies.

title: Surgical results and psychological status in XXXX with intractable M  ni  re's disease.

answer: @entity0


abstract: UNASSIGNED: Adipose tissue is considered to have endocrine properties, including factors that are considered to have angiogenic activity. The current study aimed to evaluate whether there was a difference in the efficacy of bevacizumab for metastatic @entity5 @entity0 according to their BMI (kg/m). A retrospective review of the medical records of consecutive @entity0 who were treated with bevacizumab from diagnosis for metastatic @entity5 between 2005 and 2011 was carried out. Data extracted from medical files included demographics, height, weight, comorbidities, treatment protocols, time @entity2 ( @entity2 ), and time of @entity4 . Variables were further evaluated with respect to @entity2 and @entity6 ( @entity6 ). The final analysis included 184 @entity0 . The median @entity2 was 11.7 months and the median survival was 27.6 months. Chemotherapy dose reduction [P>0.001, hazard ratio (HR)=0.6, 95% confidence interval (CI) 0.4-0.8] and male sex (P=0.03, HR=0.7, 95% CI 0.5-1.0) predicted @entity2 . Multivariate analysis indicated that @entity1 at initial presentation and/or @entity3 were associated with worse @entity6 : the median @entity6 for @entity3 was 20 versus 28.3 months for @entity0 without @entity3 (P=0.008, HR=2, 95% CI 1.2-3.4) and 23 months for @entity0 with @entity1 at initial presentation versus 31.4 months for recurrent disease (P=0.008, HR=1.6, 95% CI 1.1-2.2). No differences were found for different BMIs subdivided into groups with respect to @entity6 (P=0.84) or @entity2 (P=0.75). Our study did not show that bevacizumab is less effective in @entity0 with a high BMI. It did show that @entity3 and/or @entity1 at initial diagnosis are associated with a poorer outcome.

title: Bevacizumab for metastatic XXXX : does @entity0 BMI influence survival?

answer: @entity5


abstract: UNASSIGNED: Adipose tissue is considered to have endocrine properties, including factors that are considered to have angiogenic activity. The current study aimed to evaluate whether there was a difference in the efficacy of bevacizumab for metastatic @entity5 @entity0 according to their BMI (kg/m). A retrospective review of the medical records of consecutive @entity0 who were treated with bevacizumab from diagnosis for metastatic @entity5 between 2005 and 2011 was carried out. Data extracted from medical files included demographics, height, weight, comorbidities, treatment protocols, time @entity2 ( @entity2 ), and time of @entity4 . Variables were further evaluated with respect to @entity2 and @entity6 ( @entity6 ). The final analysis included 184 @entity0 . The median @entity2 was 11.7 months and the median survival was 27.6 months. Chemotherapy dose reduction [P>0.001, hazard ratio (HR)=0.6, 95% confidence interval (CI) 0.4-0.8] and male sex (P=0.03, HR=0.7, 95% CI 0.5-1.0) predicted @entity2 . Multivariate analysis indicated that @entity1 at initial presentation and/or @entity3 were associated with worse @entity6 : the median @entity6 for @entity3 was 20 versus 28.3 months for @entity0 without @entity3 (P=0.008, HR=2, 95% CI 1.2-3.4) and 23 months for @entity0 with @entity1 at initial presentation versus 31.4 months for recurrent disease (P=0.008, HR=1.6, 95% CI 1.1-2.2). No differences were found for different BMIs subdivided into groups with respect to @entity6 (P=0.84) or @entity2 (P=0.75). Our study did not show that bevacizumab is less effective in @entity0 with a high BMI. It did show that @entity3 and/or @entity1 at initial diagnosis are associated with a poorer outcome.

title: Bevacizumab for metastatic @entity5 : does XXXX BMI influence survival?

answer: @entity0


abstract: PURPOSE: To assess if @entity4 ( @entity4 ) occur in @entity0 with @entity5 ( @entity5 ). METHODS: A retrospective chart review was conducted in 37 @entity0 with @entity5 followed at seven different @entity1 centres in Italy, between 2002 and 2014. To assess the possible occurrence of pure @entity4 or absences associated with myoclonias, @entity4 were defined according to the following criteria: (i) a sudden onset and interruption of ongoing activities; (ii) bilateral polyspikes or spike-and-wave (SW) complexes; spike SW complexes at 2-4Hz; (iii) duration of @entity6 : 3-30seconds. RESULTS: Thirty-seven @entity5 @entity0 (25 @entity0 and 12 @entity0 ) were identified. Nine @entity0 (24.3%) had a history of simple FS during the first year of life. Ten @entity0 (27%) had a family history of @entity1 , and six @entity0 (16.2%) had a family history of FS. In 7/37 (18.9%) @entity0 , during the occurrence of MSs, a total of nineteen brief @entity4 were captured by video-EEG recordings. @entity4 occurred both during a brief cluster of rhythmic MSs than after single @entity3 . The ictal EEG abnormalities observed in @entity0 with @entity4 were similar to the ictal EEG patterns associated with only myoclonias. No differences in relation to gender, family history, ictal EEG discharge were found between @entity0 with @entity2 with @entity4 without @entity4 . CONCLUSIONS: @entity4 can occur in approximately 20% of @entity5 @entity0 and the occurrence of @entity4 , though not essential to formulate the diagnosis, do not automatically exclude the diagnosis of @entity5 .

title: Do pure XXXX occur in @entity5 ? A case series.

answer: @entity4


abstract: PURPOSE: To assess if @entity4 ( @entity4 ) occur in @entity0 with @entity5 ( @entity5 ). METHODS: A retrospective chart review was conducted in 37 @entity0 with @entity5 followed at seven different @entity1 centres in Italy, between 2002 and 2014. To assess the possible occurrence of pure @entity4 or absences associated with myoclonias, @entity4 were defined according to the following criteria: (i) a sudden onset and interruption of ongoing activities; (ii) bilateral polyspikes or spike-and-wave (SW) complexes; spike SW complexes at 2-4Hz; (iii) duration of @entity6 : 3-30seconds. RESULTS: Thirty-seven @entity5 @entity0 (25 @entity0 and 12 @entity0 ) were identified. Nine @entity0 (24.3%) had a history of simple FS during the first year of life. Ten @entity0 (27%) had a family history of @entity1 , and six @entity0 (16.2%) had a family history of FS. In 7/37 (18.9%) @entity0 , during the occurrence of MSs, a total of nineteen brief @entity4 were captured by video-EEG recordings. @entity4 occurred both during a brief cluster of rhythmic MSs than after single @entity3 . The ictal EEG abnormalities observed in @entity0 with @entity4 were similar to the ictal EEG patterns associated with only myoclonias. No differences in relation to gender, family history, ictal EEG discharge were found between @entity0 with @entity2 with @entity4 without @entity4 . CONCLUSIONS: @entity4 can occur in approximately 20% of @entity5 @entity0 and the occurrence of @entity4 , though not essential to formulate the diagnosis, do not automatically exclude the diagnosis of @entity5 .

title: Do pure @entity4 occur in XXXX ? A case series.

answer: @entity5


abstract: UNASSIGNED: Conventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for @entity0 treatment. In this study we have shown antitumor activity of @entity6 ( @entity6 ) secreted by @entity5 . One   g of @entity6 showed potent antitumor activity when injected into Ehrlich ascites @entity0 in Swiss albino @entity1 . Weekly administration of this dose is able to significantly diminish a large @entity0 volume within 3  weeks and increases the survival rates of cancerous @entity1 . @entity6 showed apoptotic activity on EAC and other malignant cells. Increased level of pro-apoptotic @entity2 with increased ratio of pro-apoptotic @entity4 to anti-apoptotic @entity3 signify that @entity6 induced apoptogenic signals lead to death of the @entity0 cells. In vivo and ex vivo studies suggest that mitochondrial dependent intrinsic pathway is responsible for this apoptosis. The level of ROS in malignant cells is reported to be higher than the normal healthy cells. @entity6 induces oxidative stress and increases the level of ROS in malignant cells which is significantly higher than the normal healthy cells. As a result the malignant cells cross the threshold level of ROS for cell survival faster than normal healthy cells. This mechanism causes @entity6 mediated apoptosis in malignant cells, but normal cells remain unaltered in the same environment. Our study suggests that @entity6 may be used as a new candidate drug for @entity0 therapy.

title: Hemagglutinin protease secreted by XXXX induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses @entity0 growth in @entity1 model.

answer: @entity5


abstract: UNASSIGNED: Conventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for @entity0 treatment. In this study we have shown antitumor activity of @entity6 ( @entity6 ) secreted by @entity5 . One   g of @entity6 showed potent antitumor activity when injected into Ehrlich ascites @entity0 in Swiss albino @entity1 . Weekly administration of this dose is able to significantly diminish a large @entity0 volume within 3  weeks and increases the survival rates of cancerous @entity1 . @entity6 showed apoptotic activity on EAC and other malignant cells. Increased level of pro-apoptotic @entity2 with increased ratio of pro-apoptotic @entity4 to anti-apoptotic @entity3 signify that @entity6 induced apoptogenic signals lead to death of the @entity0 cells. In vivo and ex vivo studies suggest that mitochondrial dependent intrinsic pathway is responsible for this apoptosis. The level of ROS in malignant cells is reported to be higher than the normal healthy cells. @entity6 induces oxidative stress and increases the level of ROS in malignant cells which is significantly higher than the normal healthy cells. As a result the malignant cells cross the threshold level of ROS for cell survival faster than normal healthy cells. This mechanism causes @entity6 mediated apoptosis in malignant cells, but normal cells remain unaltered in the same environment. Our study suggests that @entity6 may be used as a new candidate drug for @entity0 therapy.

title: Hemagglutinin protease secreted by @entity5 induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses XXXX growth in @entity1 model.

answer: @entity0


abstract: UNASSIGNED: Conventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for @entity0 treatment. In this study we have shown antitumor activity of @entity6 ( @entity6 ) secreted by @entity5 . One   g of @entity6 showed potent antitumor activity when injected into Ehrlich ascites @entity0 in Swiss albino @entity1 . Weekly administration of this dose is able to significantly diminish a large @entity0 volume within 3  weeks and increases the survival rates of cancerous @entity1 . @entity6 showed apoptotic activity on EAC and other malignant cells. Increased level of pro-apoptotic @entity2 with increased ratio of pro-apoptotic @entity4 to anti-apoptotic @entity3 signify that @entity6 induced apoptogenic signals lead to death of the @entity0 cells. In vivo and ex vivo studies suggest that mitochondrial dependent intrinsic pathway is responsible for this apoptosis. The level of ROS in malignant cells is reported to be higher than the normal healthy cells. @entity6 induces oxidative stress and increases the level of ROS in malignant cells which is significantly higher than the normal healthy cells. As a result the malignant cells cross the threshold level of ROS for cell survival faster than normal healthy cells. This mechanism causes @entity6 mediated apoptosis in malignant cells, but normal cells remain unaltered in the same environment. Our study suggests that @entity6 may be used as a new candidate drug for @entity0 therapy.

title: Hemagglutinin protease secreted by @entity5 induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses @entity0 growth in XXXX model.

answer: @entity1


abstract: Idiopathic @entity8 is a primary @entity6 characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter relaxation in response to deglutition. @entity0 with @entity8 commonly complain of @entity7 to solids and liquids, bland regurgitation often unresponsive to an adequate trial of proton pump inhibitor, and @entity4 . @entity1 is present in many, but not all @entity0 . Although the precise etiology is unknown, it is often thought to be either autoimmune, viral immune, or neurodegenerative. The diagnosis is based on history of the disease, barium esophagogram, and esophageal motility testing. Endoscopic assessment of the gastroesophageal junction and @entity2 is necessary to rule out malignancy. Newer diagnostic modalities such as high resolution manometry help in predicting treatment response in @entity8 based on esophageal pressure topography patterns identifying three phenotypes of @entity8 (I-III) and outcome studies suggest better treatment response with types I and II compared to type III. Although @entity8 cannot be permanently cured, excellent outcomes are achieved in over 90 % of @entity0 . Current medical and surgical therapeutic options ( @entity3 , @entity5 , and pharmacologic agents) aim at reducing the LES pressure and facilitating esophageal emptying by gravity and hydrostatic pressure of retained food and liquids. Either graded pneumatic dilatation or laparoscopic surgical myotomy with a partial fundoplication are recommended as initial therapy guided by @entity0 age, gender, preference, and local institutional expertise. The prognosis in @entity8 @entity0 is excellent. Most @entity0 who are appropriately treated have a normal life expectancy but the disease does recur and the @entity0 may need intermittent treatment.

title: XXXX : a review.

answer: @entity8


abstract: BACKGROUND: @entity4 associated fibroblasts (CAFs), an important component of @entity2 microenvironment, are capable of enhancing @entity2 cells invasion and migration through initiation of epithelial-mesenchymal transition (EMT). MRC-5 fibroblasts are one of the CAFs expressing alpha-smooth muscle actin. It is ascertained that medium conditioned by MRC-5 fibroblasts stimulate motility and invasion of @entity0 cells. However, its role in @entity3 ( @entity3 ) is less clear. The aim of our study was to investigate the effect of MRC-5-CM on @entity3 and explore the underlying mechanisms. METHODS AND RESULTS: Using a combination of techniques, the role of MRC-5-CM in @entity3 was evaluated. We determined that MRC-5-CM induced the non-classical EMT in Bel-7402 and MHCC- @entity1 cell lines. Initiation of the non-classical EMT was mainly via quintessential redistribution of a-, b- and y-catenin, @entity11 , @entity9 , and @entity10 , rather than up-regulation of typical EMT-related transcription factors (i.e., @entity8 , @entity12 , @entity13 and @entity14 ). We also found that MRC-5-CM potentiated both the migration and invasion of Bel-7402 and MHCC- @entity1 cells in mesenchymal movement mode through activation of the a6, b3, b4, b7 integrin/ @entity7 pathway and upregulation of @entity6 . The flow cytometric analysis showed that MRC-5-CM induced G1 phase arrest in Bel-7402 cells with a concomitant reduction of S phase cells. In contrast, MRC-5-CM induced S phase arrest in MHCC- @entity1 cells with a concomitant reduction of cells in the G2/M phase. MRC-5-CM also inhibited apoptosis in Bel-7402 cells while inducing apoptosis in MHCC- @entity1 cells. CONCLUSION: Collectively, MRC-5-CM promoted @entity3 cell motility and invasiveness through initiation of the non-classical EMT, including redistribution of a-, b- and y-catenin, @entity11 , @entity9 , and @entity10 , activation of the integrin/ @entity7 pathway, and upregulation of @entity6 . Hence, MRC-5-CM exerted distinct roles in Bel-7402 and MHCC- @entity1 cell viability by regulating cyclins, cyclin dependent kinases (CDKs), CDK inhibitors (CKIs), @entity5 family proteins and other unknown mechanosensors.

title: MRC-5 fibroblast-conditioned medium influences multiple pathways regulating invasion, migration, proliferation, and apoptosis in XXXX .

answer: @entity3


abstract: UNASSIGNED: Mature T-cell @entity1 comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow (BM) infiltration is more commonly present in mature T-cell @entity1 compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 @entity0 with mature T-cell @entity1 treated in a single institution. These included 29 cases of @entity3 ( @entity3 , all with BM infiltration) and 196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration). The estimated 5-year @entity4 ( @entity4 ) rates of @entity3 and T/NKCL were 96.6% and 37.3%, respectively. @entity3 @entity0 were less likely to exhibit poor performance status, @entity5 stage, presence of B symptoms, or abnormal level of serum @entity6 . With similar pathological characteristics, T/NKCL @entity0 with BM infiltration showed significantly lower response rates and shorter @entity4 than those without BM infiltration (P = 0.0264 and P < 0.0001, respectively). Multivariate analysis indicated that poor performance status, @entity5 stage, elevated serum @entity2 dehydrogenase level, and BM involvement were independent unfavorable prognostic factors. The Glasgow Prognostic Score may be more efficient than the International Prognostic Index in predicting disease outcome in T/NKCL. In conclusion, clinical characteristics may be useful in more effectively stratifying @entity0 with mature T-cell @entity1 .

title: Clinical characteristics and prognostic factors of @entity0 with mature T-cell XXXX : a single-institution study of 225 cases.

answer: @entity1


abstract: UNASSIGNED: Mature T-cell @entity1 comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow (BM) infiltration is more commonly present in mature T-cell @entity1 compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 @entity0 with mature T-cell @entity1 treated in a single institution. These included 29 cases of @entity3 ( @entity3 , all with BM infiltration) and 196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration). The estimated 5-year @entity4 ( @entity4 ) rates of @entity3 and T/NKCL were 96.6% and 37.3%, respectively. @entity3 @entity0 were less likely to exhibit poor performance status, @entity5 stage, presence of B symptoms, or abnormal level of serum @entity6 . With similar pathological characteristics, T/NKCL @entity0 with BM infiltration showed significantly lower response rates and shorter @entity4 than those without BM infiltration (P = 0.0264 and P < 0.0001, respectively). Multivariate analysis indicated that poor performance status, @entity5 stage, elevated serum @entity2 dehydrogenase level, and BM involvement were independent unfavorable prognostic factors. The Glasgow Prognostic Score may be more efficient than the International Prognostic Index in predicting disease outcome in T/NKCL. In conclusion, clinical characteristics may be useful in more effectively stratifying @entity0 with mature T-cell @entity1 .

title: Clinical characteristics and prognostic factors of XXXX with mature T-cell @entity1 : a single-institution study of 225 cases.

answer: @entity0


abstract: OBJECTIVE: The implementation of plan of the day selection for @entity0 receiving radiotherapy (RT) for @entity1 requires efficient and confident decision-making. This article describes the development of a training programme and maintenance of competency. METHODS: Cone beam CT (CBCT) images acquired on @entity0 receiving RT for @entity1 were assessed to establish baseline competency and training needs. A training programme was implemented, and observers were asked to select planning target volumes (PTVs) on two groups of 20 @entity0 ' images. After clinical implementation, the PTVs chosen were reviewed offline, and an audit performed after 3 years. RESULTS: A mean of 73% (range, 53-93%) concordance rate was achieved prior to training. Subsequent to training, the mean score decreased to 66% (Round 1), then increased to 76% (Round 2). Six radiographers and two clinicians successfully completed the training programme. An independent observer reviewed the images offline after clinical implementation, and a 91% (126/139) concordance rate was achieved. During the audit, 125 CBCT images from 13 @entity0 were reviewed by a single observer and concordance was 92%. CONCLUSION: Radiographer-led selection of plan of the day was implemented successfully with the use of a training programme and continual assessment. Quality has been maintained over a period of 3 years. Advances in knowledge: The training programme was successful in achieving and maintaining competency for a plan of the day technique.

title: Radiographer-led plan selection for XXXX radiotherapy: initiating a training programme and maintaining competency.

answer: @entity1


abstract: OBJECTIVES/HYPOTHESIS: To assess the comparative effectiveness of botulinum toxin and @entity2 in @entity0 with @entity1 ( @entity1 ). STUDY DESIGN: Individual prospective cohort study. METHODS: Study @entity0 were recruited at the Emory Voice Center from @entity0 seeking treatment for @entity1 . Exclusion criteria included current b-blocker treatment, @entity3 , or other disease that prevented the use of @entity2 therapy. A 10-week washout period from prior botulinum toxin treatment occurred before enrollment. @entity0 were assessed via the Voice-Related Quality-Of-Life (VRQOL) questionnaire, Quality of life in @entity1 , and blinded perceptual voice assessment. These assessments were made at baseline voice 2 weeks after @entity2 therapy and 4 weeks after botulinum toxin injection. RESULTS: Eighteen @entity0 were enrolled. After 2 to 4 weeks of @entity2 therapy (with a maximum dosage of 60 mg to 90 mg per day), @entity0 report an average   VRQOL of 9.31. Six @entity0 report significant VRQOL improvement >10, with the rest reporting changes between -7.5 and 7.5. Fifteen @entity0 were followed for at least 4 weeks after botulinum toxin injection, reporting an average improvement in scaled VRQOL of 22.00. Blinded perceptual voice assessment demonstrates an improvement in overall severity of @entity1 with botulinum toxin. CONCLUSIONS: In some @entity0 with @entity1 , @entity2 led to significant vocal improvement with no major side effects. Although botulinum toxin remains the gold-standard therapy for @entity0 with @entity1 , @entity2 represents a possible alternative or adjuvant therapy for certain @entity0 .

title: Comparative effectiveness of @entity2 and botulinum for the treatment of essential voice XXXX .

answer: @entity1


abstract: OBJECTIVES/HYPOTHESIS: To assess the comparative effectiveness of botulinum toxin and @entity2 in @entity0 with @entity1 ( @entity1 ). STUDY DESIGN: Individual prospective cohort study. METHODS: Study @entity0 were recruited at the Emory Voice Center from @entity0 seeking treatment for @entity1 . Exclusion criteria included current b-blocker treatment, @entity3 , or other disease that prevented the use of @entity2 therapy. A 10-week washout period from prior botulinum toxin treatment occurred before enrollment. @entity0 were assessed via the Voice-Related Quality-Of-Life (VRQOL) questionnaire, Quality of life in @entity1 , and blinded perceptual voice assessment. These assessments were made at baseline voice 2 weeks after @entity2 therapy and 4 weeks after botulinum toxin injection. RESULTS: Eighteen @entity0 were enrolled. After 2 to 4 weeks of @entity2 therapy (with a maximum dosage of 60 mg to 90 mg per day), @entity0 report an average   VRQOL of 9.31. Six @entity0 report significant VRQOL improvement >10, with the rest reporting changes between -7.5 and 7.5. Fifteen @entity0 were followed for at least 4 weeks after botulinum toxin injection, reporting an average improvement in scaled VRQOL of 22.00. Blinded perceptual voice assessment demonstrates an improvement in overall severity of @entity1 with botulinum toxin. CONCLUSIONS: In some @entity0 with @entity1 , @entity2 led to significant vocal improvement with no major side effects. Although botulinum toxin remains the gold-standard therapy for @entity0 with @entity1 , @entity2 represents a possible alternative or adjuvant therapy for certain @entity0 .

title: Comparative effectiveness of XXXX and botulinum for the treatment of essential voice @entity1 .

answer: @entity2


abstract: The basophil activation test (BAT) has become a pervasive test for @entity1 response through the development of flow cytometry, discovery of activation markers such as @entity4 and unique markers identifying basophil granulocytes. Basophil activation test measures basophil response to allergen cross-linking IgE on between 150 and 2000 basophil granulocytes in <0.1 ml fresh blood. Dichotomous activation is assessed as the fraction of reacting basophils. In addition to clinical history, skin prick test, and specific IgE determination, BAT can be a part of the diagnostic evaluation of @entity0 with food-, insect venom-, and drug @entity3 and chronic @entity2 . It may be helpful in determining the clinically relevant allergen. Basophil sensitivity may be used to monitor @entity0 on allergen immunotherapy, anti-IgE treatment or in the natural resolution of @entity3 . Basophil activation test may use fewer resources and be more reproducible than challenge testing. As it is less stressful for the @entity0 and avoids severe @entity1 , BAT ought to precede challenge testing. An important next step is to standardize BAT and make it available in diagnostic laboratories. The nature of basophil activation as an ex vivo challenge makes it a multifaceted and promising tool for the allergist. In this EAACI task force position paper, we provide an overview of the practical and technical details as well as the clinical utility of BAT in diagnosis and management of @entity1 .

title: The clinical utility of basophil activation testing in diagnosis and monitoring of XXXX .

answer: @entity1


abstract: Recurrence and survival data at 10 years were examined for 147 @entity1 with single axillary lymph node @entity2 found in a modified radical or standard radical mastectomy. The cases were identified through a review of all @entity1 with primary operable @entity0 treated at Memorial Hospital from 1964 to 1970. The @entity1 were stratified into groups according to size of the @entity3 and of the metastatic deposit (micro less than or equal to 2 mm; macro greater than 2 mm) as well as level of the positive node. In the entire series, there was a significantly poorer prognosis among those @entity1 with single macrometastases (30/77 @entity1 ; 39% recurrence rate) when compared with those having micrometastases (17/70 @entity1 : 24% recurrence rate). A major prognostic difference emerged after stratification by @entity3 size. Within the first six years of the follow-up period, T1 @entity1 with negative nodes and those with single micrometastases had similar survival curves, significantly better than those with macrometastases. However, at 12 years, the survival @entity4 of those @entity1 with either a micro- or macrometastases was nearly identical, and significantly worse than for those @entity1 with negative lymph nodes. On the other hand, among @entity1 with @entity3 2.1-5.0 cm (T2), @entity1 with negative lymph nodes or single micrometastases had survival curves that did not differ significantly throughout the course of the follow-up period. Both had an outcome significantly better than observed for @entity1 with macrometastases. These findings have important implications for our understanding of the clinical behaviour of @entity0 and for the stratification of @entity1 entered into randomized treatment trials.

title: Axillary micro- and macrometastases in XXXX : prognostic significance of @entity3 size.

answer: @entity0


abstract: Recurrence and survival data at 10 years were examined for 147 @entity1 with single axillary lymph node @entity2 found in a modified radical or standard radical mastectomy. The cases were identified through a review of all @entity1 with primary operable @entity0 treated at Memorial Hospital from 1964 to 1970. The @entity1 were stratified into groups according to size of the @entity3 and of the metastatic deposit (micro less than or equal to 2 mm; macro greater than 2 mm) as well as level of the positive node. In the entire series, there was a significantly poorer prognosis among those @entity1 with single macrometastases (30/77 @entity1 ; 39% recurrence rate) when compared with those having micrometastases (17/70 @entity1 : 24% recurrence rate). A major prognostic difference emerged after stratification by @entity3 size. Within the first six years of the follow-up period, T1 @entity1 with negative nodes and those with single micrometastases had similar survival curves, significantly better than those with macrometastases. However, at 12 years, the survival @entity4 of those @entity1 with either a micro- or macrometastases was nearly identical, and significantly worse than for those @entity1 with negative lymph nodes. On the other hand, among @entity1 with @entity3 2.1-5.0 cm (T2), @entity1 with negative lymph nodes or single micrometastases had survival curves that did not differ significantly throughout the course of the follow-up period. Both had an outcome significantly better than observed for @entity1 with macrometastases. These findings have important implications for our understanding of the clinical behaviour of @entity0 and for the stratification of @entity1 entered into randomized treatment trials.

title: Axillary micro- and macrometastases in @entity0 : prognostic significance of XXXX size.

answer: @entity3


abstract: OBJECTIVES: @entity4 inhibitors (PARPi) are a novel class of drugs with activity in @entity0 with acquired or germline homologous recombination (HR) deficiency-associated high-grade serous @entity1 (HGSOC). We hypothesized that measuring yH2AX as an indicator of DNA double-strand breaks (DSB), and @entity5 or @entity3 as an indicator of DSB repair, would reflect HR status and predict response to PARPi-based therapy. Our aim was to develop and use high-throughput multiparametric flow cytometry to quantify yH2AX with @entity5 or @entity3 in PBMCs as a readily available surrogate. METHODS: Healthy donor PBMCs were used for assay development and optimization. We validated induction of yH2AX, @entity5 and @entity3 by staining with fluorophore-conjugated antibodies. The multiparameter flow cytometric method was applied to PBMC samples from recurrent HGSOC @entity0 who were treated with PARPi, olaparib and @entity2 . RESULTS: Stimulation was necessary for quantification of a DNA damage response to olaparib/ @entity2 in healthy donor PBMCs. The flow cytometric protocol could not distinguish between cytoplasmic and nuclear @entity3 , erroneously indicating activation in response to injury. Thus, @entity5 was selected as the marker of DSB repair. PBMCs from 15 recurrent HGSOC @entity0 were then examined. @entity0 who did not respond to PARPi therapy had a significantly higher pre-treatment level of yH2AX (p  =  0.01), and a higher ratio of yH2AX/ @entity5 (11.0 [3.5-13.2] v. 3.3 [2.8-9.9], p  <  0.03) compared with responders. CONCLUSIONS: We successfully developed and applied a multiparameter flow cytometry assay to measure yH2AX and @entity5 in PBMCs. Prospective studies will be required to validate this surrogate biomarker assay as a potential predictive biomarker of PARPi-based therapy.

title: Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in @entity0 with high-grade serous XXXX .

answer: @entity1


abstract: OBJECTIVES: @entity4 inhibitors (PARPi) are a novel class of drugs with activity in @entity0 with acquired or germline homologous recombination (HR) deficiency-associated high-grade serous @entity1 (HGSOC). We hypothesized that measuring yH2AX as an indicator of DNA double-strand breaks (DSB), and @entity5 or @entity3 as an indicator of DSB repair, would reflect HR status and predict response to PARPi-based therapy. Our aim was to develop and use high-throughput multiparametric flow cytometry to quantify yH2AX with @entity5 or @entity3 in PBMCs as a readily available surrogate. METHODS: Healthy donor PBMCs were used for assay development and optimization. We validated induction of yH2AX, @entity5 and @entity3 by staining with fluorophore-conjugated antibodies. The multiparameter flow cytometric method was applied to PBMC samples from recurrent HGSOC @entity0 who were treated with PARPi, olaparib and @entity2 . RESULTS: Stimulation was necessary for quantification of a DNA damage response to olaparib/ @entity2 in healthy donor PBMCs. The flow cytometric protocol could not distinguish between cytoplasmic and nuclear @entity3 , erroneously indicating activation in response to injury. Thus, @entity5 was selected as the marker of DSB repair. PBMCs from 15 recurrent HGSOC @entity0 were then examined. @entity0 who did not respond to PARPi therapy had a significantly higher pre-treatment level of yH2AX (p  =  0.01), and a higher ratio of yH2AX/ @entity5 (11.0 [3.5-13.2] v. 3.3 [2.8-9.9], p  <  0.03) compared with responders. CONCLUSIONS: We successfully developed and applied a multiparameter flow cytometry assay to measure yH2AX and @entity5 in PBMCs. Prospective studies will be required to validate this surrogate biomarker assay as a potential predictive biomarker of PARPi-based therapy.

title: Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in XXXX with high-grade serous @entity1 .

answer: @entity0


abstract: OBJECTIVES: The impact of characteristics of neighbourhood environment on physical activity and @entity2 is still the subject of debate. This study aimed to explore the impact of urban neighbourhood environment on physical activity and @entity2 . STUDY DESIGN: Cross-sectional study. METHODS: Individuals who participated in the 2009 national health-screening programme, submitted all necessary information, and had lived in Community 1 (Haengdang) or Community 2 (Ilsan) for at least 2 years (n  =  16,178) were selected for inclusion in this study. Anthropometric measures were taken and physical activity was assessed using a short questionnaire. RESULTS: No significant difference in the trigger factors for walking, including the amount of neighbourhood park space, number of shopping malls, and distance between the community and shopping malls, was found between the two communities. However, Community 2 had a better street environment than Community 1. @entity0 who lived in Community 2 were more physically active [adjusted odds ratio (OR) 1.31, 95% confidence interval (CI) 1.16-1.48] and walked more regularly (adjusted OR 1.09, 95% CI 1.02-1.17) than @entity0 who lived in Community 1, and were less likely to have @entity5 (adjusted OR 0.83, 95% CI 0.77-0.91), @entity3 (adjusted OR 0.88, 95% CI 0.80-0.97) and @entity1 (adjusted OR 0.86, 95% CI 0.75-0.99). However, the risk of dyslipidaemia, especially in terms of low-density lipoprotein @entity4 , was higher in Community 2. CONCLUSIONS: These results suggest that a walkable environment has a positive influence on @entity3 and @entity1 , and physical activity is the possible mechanism for this association. A walkable environment may function as an important tool for health promotion in urban areas.

title: Influence of urban neighbourhood environment on physical activity and XXXX .

answer: @entity2


abstract: @entity4 ( @entity4 ) is defined as the @entity4 of a minimum of 30 dB in at least three frequencies for three days or more. This study aims to evaluate the clinical efficacy of hyperbaric @entity1 therapy (HBO2) in the management of @entity4 . MATERIAL-METHODS: @entity0 with @entity4 received treatment including oral @entity2 and HBO2. HBO2 protocol included five phases of five sessions each. @entity4 was assessed by measuring the tonal audiogram before and after each phase. @entity3 was assessed using a questionnaire and a visual analogue scale at the beginning and the end of the study. Secondary assessment points included changes in the intensity and the improvement of @entity3 . RESULTS: 56 @entity0 were included in the study. All @entity0 completed Phases I and II of HBO2, 43 completed Phase III, 13 completed Phase IV, and six completed all five phases. Overall, a significant improvement was noted between the initial and final audiogram after HBO2 (p < 0.001). @entity3 evaluation score, intensity and related problems were also significantly reduced (p < 0.001). CONCLUSION: This study affirms previous findings that the use of HBO2 and vasodilators are efficacious in the treatment of @entity4 . Our findings also suggest benefit for the treatment of @entity3 .

title: Management of sudden hearing loss with hyperbaric XXXX therapy.

answer: @entity1


abstract: PURPOSE: To compare the postoperative recovery of @entity0 with superior @entity1 ( @entity4 ) following conventional open surgery vs. a hybrid video-assisted and limited open approach (VALO). METHODS: The subjects of this retrospective study were 20 @entity0 we operated on to resect a @entity4 . All @entity0 received induction chemo-radiation followed by surgery, performed via either a conventional thoracotomy approach (n  =  10) or the hybrid VALO approach (n  =  10). In the hybrid VALO group, lobectomy and internal chest wall preparation were performed using a video technique, with rib resection and specimen removal through a limited incision. RESULTS: There was no mortality in either group. Two @entity0 from the thoracotomy group required mechanical ventilation, but there was no major morbidity in the hybrid VALO group. The operative times were similar for the two procedures. The average length of hospital stay  was shorter and the average @entity2 scores were significantly lower in the hybrid VALO group. The incidence of @entity3 was 10  % in the hybrid VALO group vs. 50  % in the thoracotomy group. CONCLUSIONS: Hybrid VALO resection of @entity4 is feasible and safe, resulting in faster @entity0 recovery and a significantly lower incidence of severe @entity3 than open thoracotomy. We conclude that centers experienced with video-assisted lobectomy should consider hybrid VALO surgery as the procedure of choice for @entity4 .

title: Hybrid video-assisted and limited open (VALO) resection of superior XXXX .

answer: @entity1


abstract: PURPOSE: To compare the diagnostic ability of specimen radiography using @entity2 ( @entity2 ) and digital breast tomosynthesis (DBT) for detecting @entity0 and evaluating its extension in the intraoperative specimen. METHODS: Sixty-five specimens from 65 @entity1 (median 62  years; range 34-86) obtained during breast-conserving surgery were prospectively investigated. Specimens underwent @entity2 (25-40 kVp, 12-322 mA  s) and DBT (25-34 kVp, 13-137  mA) in two orthogonal planes, anteroposterior (AP) and latero-lateral (LL). Images were interpreted by a radiologist to detect invasive lesions and their extensive @entity3 in situ ( @entity3 ); afterwards, they were compared with histopathological findings. RESULTS: In AP views, 96  % of the invasive lesions were detected by both the methods. Of the EICs, 55 and 65  % were detected by @entity2 and DBT, respectively (P  =  0.61). Of the DICSs, 31 and 38  % were detected by @entity2 and DBT, respectively (P  >  0.99). In LL views, 71 and 13  % of the invasive lesions were detected by DBT and @entity2 , respectively (P  <  0.0001). Of the EICs, 42 and 10  % were detected by DBT and @entity2 , respectively (P  =  0.0078). Of the 13 DCISs, 42 and 8  % were detected by DBT and @entity2 , respectively (P  =  0.32). The whole lesion and contour could be delineated in 45  % by DBT and in 6.2  % by @entity2 (P  <  0.0001). CONCLUSIONS: DBT could detect @entity0 more accurately than @entity2 in LL views, indicating its potential to more precisely diagnose vertical invasion.

title: Digital mammography versus digital breast tomosynthesis for detection of XXXX in the intraoperative specimen during breast-conserving surgery.

answer: @entity0


abstract: OBJECTIVE: The need to achieve a @entity1 -free margin of >= 1 mm (R0) for @entity2 ( @entity2 ) after hepatic resection has been questioned recently. This study conducted a meta-analysis to determine whether status of the surgical margin still influenced the long-term outcome of survival and recurrence rate. METHODS: Eligible trials that compared survival and recurrence rates of R0 versus the @entity1 -free margin <1 mm (R1) were identified from Embase, PubMed, the Web of Science, and the Cochrane Library since their inception to 1 March 2015. The study outcomes included long-term outcome of survival and recurrence rate. Hazard ratio (HR) with a 95 % confidence interval was used to measure the pooled effect according to a random-effects model or fixed-effects model, depending on the heterogeneity among the included studies. The heterogeneity among these trials was statistically evaluated using the   (2) and I(2) tests. Sensitivity analyses and publication bias were also carried out. RESULTS: A total of 18 studies containing 6790 @entity0 were included. The comparison between @entity3 revealed that a pooled HR for 5-year overall survival was 1.603 (95 % CI; 1.464-1.755; p   =   0.000; I(2)   =   31.2 %, p   =   0.141). For @entity0 received modern chemotherapy; a pooled HR of R1 resection for 5-year overall survival was 1.924 (95 % CI; 1.567-2.361, p   =   0.000; I(2)   =   20.5 %, p   =   0.273). The pooled HR for 5-year OS of >= 1 cm in the included studies calculated using the random-effects model was 0.819 (95 % CI; 0.715-0.938, p   =   0.004; I(2)   =   0 %, p   =   0.492). CONCLUSIONS: R1 resections decreased long-term survival, and modern chemotherapy did not alter an adverse outcome. Surgeons should attempt to obtain a 1-cm margin.

title: Negative surgical margin improved long-term survival of XXXX after hepatic resection: a systematic review and meta-analysis.

answer: @entity2


abstract: A @entity0 @entity2 cell line, 45.6.3, produces an @entity6 immunoglobulin (Ig) with 2 @entity3 attachment sites on the heavy chains. One site is in the @entity1 domain and the other in the VH region. The oligosaccharides at each site have different structures. The ratio of radioactive @entity4 incorporated in the VH compared with the @entity1 oligosaccharide is approximately 1 to 3. In an attempt to understand this observation further, variant cell lines derived from 45.6.3 were isolated and their Ig were characterized. A ricin-resistant line, R4R1.5, has the same 2 attachment sites as the wild type, but the ratio of radioactive @entity4 in VH compared with @entity1 was 1:1 and not 1:3 as in the wild type. This alteration is most probably due to cellular factors, since the Ig protein is unchanged. The M3.11 cell line produces an Ig with a polypeptide deletion involving the @entity5 domain. In this Ig, a 3rd @entity3 attachment site can be demonstrated. The percentage of radioactivity @entity4 in the @entity1 domain compared with the total Ig is about 25% instead of 75% as in the wild type. These results suggest that the extent of glycosylation of different sites on Ig can be affected by both cellular factors and structural changes in the Ig protein.

title: Immunoglobulin glycopeptides from an XXXX -producing @entity0 @entity2 cell line and from variant cell lines.

answer: @entity6


abstract: A @entity0 @entity2 cell line, 45.6.3, produces an @entity6 immunoglobulin (Ig) with 2 @entity3 attachment sites on the heavy chains. One site is in the @entity1 domain and the other in the VH region. The oligosaccharides at each site have different structures. The ratio of radioactive @entity4 incorporated in the VH compared with the @entity1 oligosaccharide is approximately 1 to 3. In an attempt to understand this observation further, variant cell lines derived from 45.6.3 were isolated and their Ig were characterized. A ricin-resistant line, R4R1.5, has the same 2 attachment sites as the wild type, but the ratio of radioactive @entity4 in VH compared with @entity1 was 1:1 and not 1:3 as in the wild type. This alteration is most probably due to cellular factors, since the Ig protein is unchanged. The M3.11 cell line produces an Ig with a polypeptide deletion involving the @entity5 domain. In this Ig, a 3rd @entity3 attachment site can be demonstrated. The percentage of radioactivity @entity4 in the @entity1 domain compared with the total Ig is about 25% instead of 75% as in the wild type. These results suggest that the extent of glycosylation of different sites on Ig can be affected by both cellular factors and structural changes in the Ig protein.

title: Immunoglobulin glycopeptides from an @entity6 -producing @entity0 XXXX cell line and from variant cell lines.

answer: @entity2


abstract: A @entity0 @entity2 cell line, 45.6.3, produces an @entity6 immunoglobulin (Ig) with 2 @entity3 attachment sites on the heavy chains. One site is in the @entity1 domain and the other in the VH region. The oligosaccharides at each site have different structures. The ratio of radioactive @entity4 incorporated in the VH compared with the @entity1 oligosaccharide is approximately 1 to 3. In an attempt to understand this observation further, variant cell lines derived from 45.6.3 were isolated and their Ig were characterized. A ricin-resistant line, R4R1.5, has the same 2 attachment sites as the wild type, but the ratio of radioactive @entity4 in VH compared with @entity1 was 1:1 and not 1:3 as in the wild type. This alteration is most probably due to cellular factors, since the Ig protein is unchanged. The M3.11 cell line produces an Ig with a polypeptide deletion involving the @entity5 domain. In this Ig, a 3rd @entity3 attachment site can be demonstrated. The percentage of radioactivity @entity4 in the @entity1 domain compared with the total Ig is about 25% instead of 75% as in the wild type. These results suggest that the extent of glycosylation of different sites on Ig can be affected by both cellular factors and structural changes in the Ig protein.

title: Immunoglobulin glycopeptides from an @entity6 -producing XXXX @entity2 cell line and from variant cell lines.

answer: @entity0


abstract: BACKGROUND: Understanding and improving medication adherence is crucial in @entity1 management. Adherence to a @entity1 regimen can improve glucose control and limit the development of complications. The aim of the present study was to evaluate the extent to which a variety of factors influence @entity1 medication adherence. METHODS: A medication adherence survey was made available on WebMD, a medical information website for @entity0 and/or consumers. Respondents were residents of the US, >= 18 years old, and diagnosed with either type 1 or @entity1 (self-reported). RESULTS: Behavioral adherence (self-reported doses missed per week) correlated with perceived adherence ( @entity0 ' self-report of their overall impression of medication adherence, ranked 0-5; P < 0.001). Adherent @entity0 (very few [0%-10%] issues with adherence) were more likely to report having received information from their physician. Mostly adherent @entity0 (few [11%-26%] issues with adherence) were less likely to obtain information from their physician, but reported more medication self-titration. Somewhat non-adherent @entity0 (some [27%-46%] adherence issues) reported more "self-consciousness factors" and @entity2 . Non-adherent @entity0 (many [47%-88%] adherence issues) were more likely to report worries about medication side effects. CONCLUSIONS: Receiving information from a healthcare provider is associated with greater @entity1 medication adherence, suggesting the importance of clinicians making time to provide @entity0 education.

title: Determinants of adherence to XXXX treatment.

answer: @entity1