abstract: @entity6 during the earliest stages of life may result in innumerable brain problems. Moreover, this condition could increase the chances of developing @entity0 , such as @entity3 . We analyzed the effects of early-life @entity6 on susceptibility to @entity3 induced by the @entity5 model of @entity3 . @entity1 @entity1 pups were kept on a starvation regimen from day 1 to day 21 after birth. At day 60, 16 animals (8 = well-nourished; 8 = malnourished) were exposed to the @entity5 experimental model of @entity3 . Age-matched well-nourished (n = 8) and malnourished (n = 8) @entity1 were used as controls. Animals were video-monitored over 9 weeks. The following behavioral parameters were evaluated: first @entity4 threshold (acute period of the @entity5 model); @entity2 ( @entity2 ) latency; first spontaneous @entity4 latency (silent period), and spontaneous @entity4 frequency during the chronic phase. The cell and @entity7 ( @entity7 ) density were evaluated in the hippocampal formation. Our results showed that the malnourished animals required a lower @entity5 dose in order to develop @entity2 (200 mg/kg), lower latency to reach @entity2 , less time for the first spontaneous @entity4 and higher @entity4 frequency, when compared to well-nourished @entity5 @entity1 . Histopathological findings revealed a significant cell density reduction in the CA1 region and intense @entity7 among the malnourished animals. Our data indicate that early @entity6 greatly influences susceptibility to @entity4 and behavioral manifestations in adult life. These findings suggest that @entity6 in infancy reduces the threshold for @entity3 and promotes alterations in the brain that persist into adult life.

title: @entity6 in infancy as a susceptibility factor for temporal lobe epilepsy in adulthood induced by the XXXX experimental model.

answer: @entity5


abstract: OBJECTIVE: Recent studies support the use of endovascular treatment for @entity4 , but few studies have examined the use of thoracic endovascular aortic repair (TEVAR) for @entity2 descending thoracic @entity3 . We evaluated nationwide data regarding short-term outcomes of TEVAR and open aortic repair ( @entity6 ) for @entity2 descending thoracic @entity3 . METHODS: From US Nationwide Inpatient Sample data, we identified 923 @entity0 who underwent @entity2 descending thoracic @entity3 repair in 2006-2008 and who had no concomitant @entity5 . Of these @entity0 , 364 (39.4%) underwent TEVAR and 559 (60.6%) underwent @entity6 . Multivariable regression was used to assess the effect of TEVAR versus @entity6 after adjusting for potential confounding factors. Outcomes assessed were in-hospital mortality, complications, failure to rescue (defined as the mortality among @entity0 in whom a complication develops), and disposition. Backward stepwise logistic regression was used to identify independent predictors of outcomes for each approach. RESULTS: @entity0 undergoing TEVAR were older (72    12 years vs 65    15 years; P < .001) and had a higher Deyo comorbidity index (4.19    1.79 vs 3.14    2.05; P < .001) than @entity0 undergoing @entity6 . Unadjusted mortality was 23.4% (85/364) for TEVAR and 28.6% (160/559) for @entity6 . After risk adjustment, the odds of mortality, complications, and failure to rescue were similar for @entity6 (P > .1 for all), but @entity0 undergoing TEVAR had a greater chance of routine discharge (odds ratio [OR] = 3.3; P < .001). An interaction was identified that linked hospital size and operative approach with risk of complications (P < .001). In smaller hospitals, TEVAR was associated with lower complication rates than @entity6 (OR = 0.21; P < .05). Regression analysis revealed that smaller hospital size predicted significantly higher rates of mortality (OR = 2.4; P < .05), complications (OR = 4.0; P < .005), and failure to rescue (OR = 51.12; P < .001) in those undergoing @entity6 but not in those undergoing TEVAR. Preexisting @entity1 substantially increased mortality risk (OR = 10.81; P < .001) and failure to rescue (OR = 309.54; P < .001) in @entity0 undergoing TEVAR. CONCLUSIONS: Nationwide data for @entity2 descending thoracic @entity3 reveal equivalent mortality, complication rates, and failure to rescue for TEVAR and @entity6 but more frequent routine discharge with TEVAR. Unlike @entity6 outcomes, TEVAR outcomes were not poorer in smaller hospitals, where TEVAR produced fewer complications than @entity6 . Therefore, TEVAR may be an ideal alternative to @entity6 for @entity2 descending thoracic @entity3 , particularly in small hospitals where expertise in @entity6 may be lacking and immediate transfer to a higher echelon of care may not be feasible.

title: Endovascular versus open repair of XXXX descending thoracic aortic aneurysms: a nationwide risk-adjusted study of 923 @entity0 .

answer: @entity2


abstract: OBJECTIVE: Recent studies support the use of endovascular treatment for @entity4 , but few studies have examined the use of thoracic endovascular aortic repair (TEVAR) for @entity2 descending thoracic @entity3 . We evaluated nationwide data regarding short-term outcomes of TEVAR and open aortic repair ( @entity6 ) for @entity2 descending thoracic @entity3 . METHODS: From US Nationwide Inpatient Sample data, we identified 923 @entity0 who underwent @entity2 descending thoracic @entity3 repair in 2006-2008 and who had no concomitant @entity5 . Of these @entity0 , 364 (39.4%) underwent TEVAR and 559 (60.6%) underwent @entity6 . Multivariable regression was used to assess the effect of TEVAR versus @entity6 after adjusting for potential confounding factors. Outcomes assessed were in-hospital mortality, complications, failure to rescue (defined as the mortality among @entity0 in whom a complication develops), and disposition. Backward stepwise logistic regression was used to identify independent predictors of outcomes for each approach. RESULTS: @entity0 undergoing TEVAR were older (72    12 years vs 65    15 years; P < .001) and had a higher Deyo comorbidity index (4.19    1.79 vs 3.14    2.05; P < .001) than @entity0 undergoing @entity6 . Unadjusted mortality was 23.4% (85/364) for TEVAR and 28.6% (160/559) for @entity6 . After risk adjustment, the odds of mortality, complications, and failure to rescue were similar for @entity6 (P > .1 for all), but @entity0 undergoing TEVAR had a greater chance of routine discharge (odds ratio [OR] = 3.3; P < .001). An interaction was identified that linked hospital size and operative approach with risk of complications (P < .001). In smaller hospitals, TEVAR was associated with lower complication rates than @entity6 (OR = 0.21; P < .05). Regression analysis revealed that smaller hospital size predicted significantly higher rates of mortality (OR = 2.4; P < .05), complications (OR = 4.0; P < .005), and failure to rescue (OR = 51.12; P < .001) in those undergoing @entity6 but not in those undergoing TEVAR. Preexisting @entity1 substantially increased mortality risk (OR = 10.81; P < .001) and failure to rescue (OR = 309.54; P < .001) in @entity0 undergoing TEVAR. CONCLUSIONS: Nationwide data for @entity2 descending thoracic @entity3 reveal equivalent mortality, complication rates, and failure to rescue for TEVAR and @entity6 but more frequent routine discharge with TEVAR. Unlike @entity6 outcomes, TEVAR outcomes were not poorer in smaller hospitals, where TEVAR produced fewer complications than @entity6 . Therefore, TEVAR may be an ideal alternative to @entity6 for @entity2 descending thoracic @entity3 , particularly in small hospitals where expertise in @entity6 may be lacking and immediate transfer to a higher echelon of care may not be feasible.

title: Endovascular versus open repair of @entity2 descending thoracic aortic aneurysms: a nationwide risk-adjusted study of 923 XXXX .

answer: @entity0


abstract: BACKGROUND: Infliximab is indicated for treatment of moderate-to-severe @entity3 in adults whose disease cannot be controlled with other systemic therapies, including @entity1 ( @entity2 ). To date, no studies have directly compared the efficacy and safety of infliximab and @entity2 . OBJECTIVES: To compare the efficacy and safety of infliximab vs. @entity2 in adults with moderate-to-severe @entity3 . METHODS: @entity2 -na  ve @entity0 (n = 868) were randomized 3:1 to receive infliximab 5 mg kg      at weeks 0, 2, 6, 14 and 22 or @entity2 15 mg weekly with a dose increase to 20 mg weekly at week 6 if the Psoriasis Area and Severity Index (PASI) response was < 25%. At week 16, @entity0 with <   PASI 50 response could switch treatment groups. The primary efficacy endpoint was PASI 75 response at week 16. Major secondary efficacy endpoints were PASI 75 response at week 26, and the proportion of @entity0 achieving a Physician's Global Assessment (PGA) score of cleared (0) or minimal (1) at weeks 16 and 26. Others included Dermatology Life Quality Index, 36-Item Short Form Health Survey, and @entity4 , PASI 50, PASI 75 and PASI 90 responses over time. RESULTS: The primary endpoint was achieved by a significantly greater proportion of infliximab-treated @entity0 (508/653, 78%) than @entity2 -treated @entity0 (90/215, 42%; P < 0  001). Key secondary endpoints also were achieved by a greater proportion of infliximab-treated @entity0 . Similar responses were observed at week 26 in @entity0 who switched from @entity2 to infliximab at week 16. Overall adverse event (AE) incidence was comparable between groups, but incidence of serious and severe AEs was slightly higher in the infliximab group. CONCLUSIONS: Infliximab was well tolerated and more efficacious than @entity2 in @entity0 with moderate-to-severe @entity3 . Infliximab also was efficacious in @entity0 who failed @entity2 and switched to infliximab.

title: Efficacy and safety of infliximab vs. XXXX in @entity0 with moderate-to-severe @entity3 : results of an open-label, active-controlled, randomized trial (RESTORE1).

answer: @entity1


abstract: BACKGROUND: Infliximab is indicated for treatment of moderate-to-severe @entity3 in adults whose disease cannot be controlled with other systemic therapies, including @entity1 ( @entity2 ). To date, no studies have directly compared the efficacy and safety of infliximab and @entity2 . OBJECTIVES: To compare the efficacy and safety of infliximab vs. @entity2 in adults with moderate-to-severe @entity3 . METHODS: @entity2 -na  ve @entity0 (n = 868) were randomized 3:1 to receive infliximab 5 mg kg      at weeks 0, 2, 6, 14 and 22 or @entity2 15 mg weekly with a dose increase to 20 mg weekly at week 6 if the Psoriasis Area and Severity Index (PASI) response was < 25%. At week 16, @entity0 with <   PASI 50 response could switch treatment groups. The primary efficacy endpoint was PASI 75 response at week 16. Major secondary efficacy endpoints were PASI 75 response at week 26, and the proportion of @entity0 achieving a Physician's Global Assessment (PGA) score of cleared (0) or minimal (1) at weeks 16 and 26. Others included Dermatology Life Quality Index, 36-Item Short Form Health Survey, and @entity4 , PASI 50, PASI 75 and PASI 90 responses over time. RESULTS: The primary endpoint was achieved by a significantly greater proportion of infliximab-treated @entity0 (508/653, 78%) than @entity2 -treated @entity0 (90/215, 42%; P < 0  001). Key secondary endpoints also were achieved by a greater proportion of infliximab-treated @entity0 . Similar responses were observed at week 26 in @entity0 who switched from @entity2 to infliximab at week 16. Overall adverse event (AE) incidence was comparable between groups, but incidence of serious and severe AEs was slightly higher in the infliximab group. CONCLUSIONS: Infliximab was well tolerated and more efficacious than @entity2 in @entity0 with moderate-to-severe @entity3 . Infliximab also was efficacious in @entity0 who failed @entity2 and switched to infliximab.

title: Efficacy and safety of infliximab vs. @entity1 in @entity0 with moderate-to-severe XXXX : results of an open-label, active-controlled, randomized trial (RESTORE1).

answer: @entity3


abstract: BACKGROUND: Infliximab is indicated for treatment of moderate-to-severe @entity3 in adults whose disease cannot be controlled with other systemic therapies, including @entity1 ( @entity2 ). To date, no studies have directly compared the efficacy and safety of infliximab and @entity2 . OBJECTIVES: To compare the efficacy and safety of infliximab vs. @entity2 in adults with moderate-to-severe @entity3 . METHODS: @entity2 -na  ve @entity0 (n = 868) were randomized 3:1 to receive infliximab 5 mg kg      at weeks 0, 2, 6, 14 and 22 or @entity2 15 mg weekly with a dose increase to 20 mg weekly at week 6 if the Psoriasis Area and Severity Index (PASI) response was < 25%. At week 16, @entity0 with <   PASI 50 response could switch treatment groups. The primary efficacy endpoint was PASI 75 response at week 16. Major secondary efficacy endpoints were PASI 75 response at week 26, and the proportion of @entity0 achieving a Physician's Global Assessment (PGA) score of cleared (0) or minimal (1) at weeks 16 and 26. Others included Dermatology Life Quality Index, 36-Item Short Form Health Survey, and @entity4 , PASI 50, PASI 75 and PASI 90 responses over time. RESULTS: The primary endpoint was achieved by a significantly greater proportion of infliximab-treated @entity0 (508/653, 78%) than @entity2 -treated @entity0 (90/215, 42%; P < 0  001). Key secondary endpoints also were achieved by a greater proportion of infliximab-treated @entity0 . Similar responses were observed at week 26 in @entity0 who switched from @entity2 to infliximab at week 16. Overall adverse event (AE) incidence was comparable between groups, but incidence of serious and severe AEs was slightly higher in the infliximab group. CONCLUSIONS: Infliximab was well tolerated and more efficacious than @entity2 in @entity0 with moderate-to-severe @entity3 . Infliximab also was efficacious in @entity0 who failed @entity2 and switched to infliximab.

title: Efficacy and safety of infliximab vs. @entity1 in XXXX with moderate-to-severe @entity3 : results of an open-label, active-controlled, randomized trial (RESTORE1).

answer: @entity0


abstract: STATEMENT OF PROBLEM: Even though mechanical retentive features, such as grooves, are incorporated into the surface of @entity0 alloy temporary cylinders, a reliable bond to veneering provisional materials is not always achievable for screw-retained provisional implant restorations. There is insufficient information about the effect of tribochemical @entity1 coating on the bond strength between provisional materials and grooved @entity0 alloy temporary cylinders. PURPOSE: The purpose of this study was to evaluate, in vitro, the effect of an airborne-particle abrasion and @entity1 -coating technique on the bond strength between grooved @entity0 alloy temporary cylinders and provisional veneering @entity3 and @entity2 materials. MATERIAL AND METHODS: Forty grooved @entity0 alloy ( @entity4 ) internal connection implant temporary cylinders were used. A disc of veneering material (7.1   3.4 mm) was created around the midsection of each cylinder. Forty specimens were divided into 4 groups (n=10): group NoTx @entity2 , no surface treatment and @entity2 veneering material; group NoTxBisGMA, no surface treatment and BisGMA veneering material; group Ab @entity2 , airborne-particle abrasion, @entity1 -coating surface treatment (Rocatec), and @entity2 ; and group AbBisGMA, airborne-particle abrasion, @entity1 -coating surface treatment (Rocatec), and BisGMA. Each specimen was subjected to ultimate shear load testing at the interface of the veneering material and the temporary cylinder in a universal testing machine at a constant crosshead speed of 5 mm/min. Data were analyzed with a 1-way ANOVA (a=.05) followed by post hoc Student-Newman-Keuls test. Each specimen underwent surface observation with a light microscope at  40 magnification to compare fracture patterns. RESULTS: Airborne-particle abrasion and @entity1 -coating surface treatment significantly lowered the shear bond strength (P<.05). The type of provisional material did not significantly affect the shear bond strength, with or without surface treatment. Group AbBisGMA demonstrated the lowest mean value (3.49 MPa) compared to the other groups. CONCLUSIONS: Airborne-particle abrasion and @entity1 -coating treatment did not improve the bond between grooved @entity0 alloy temporary cylinders and provisional veneering materials. It weakened the provided mechanical retention, especially when it was used with BisGMA veneering material. Material choice, whether it was @entity2 or @entity3 , did not make a statistically significant difference.

title: The effects of an airborne-particle abrasion and @entity1 -coating on the bond strength between grooved XXXX alloy temporary cylinders and provisional veneering materials.

answer: @entity0


abstract: STATEMENT OF PROBLEM: Even though mechanical retentive features, such as grooves, are incorporated into the surface of @entity0 alloy temporary cylinders, a reliable bond to veneering provisional materials is not always achievable for screw-retained provisional implant restorations. There is insufficient information about the effect of tribochemical @entity1 coating on the bond strength between provisional materials and grooved @entity0 alloy temporary cylinders. PURPOSE: The purpose of this study was to evaluate, in vitro, the effect of an airborne-particle abrasion and @entity1 -coating technique on the bond strength between grooved @entity0 alloy temporary cylinders and provisional veneering @entity3 and @entity2 materials. MATERIAL AND METHODS: Forty grooved @entity0 alloy ( @entity4 ) internal connection implant temporary cylinders were used. A disc of veneering material (7.1   3.4 mm) was created around the midsection of each cylinder. Forty specimens were divided into 4 groups (n=10): group NoTx @entity2 , no surface treatment and @entity2 veneering material; group NoTxBisGMA, no surface treatment and BisGMA veneering material; group Ab @entity2 , airborne-particle abrasion, @entity1 -coating surface treatment (Rocatec), and @entity2 ; and group AbBisGMA, airborne-particle abrasion, @entity1 -coating surface treatment (Rocatec), and BisGMA. Each specimen was subjected to ultimate shear load testing at the interface of the veneering material and the temporary cylinder in a universal testing machine at a constant crosshead speed of 5 mm/min. Data were analyzed with a 1-way ANOVA (a=.05) followed by post hoc Student-Newman-Keuls test. Each specimen underwent surface observation with a light microscope at  40 magnification to compare fracture patterns. RESULTS: Airborne-particle abrasion and @entity1 -coating surface treatment significantly lowered the shear bond strength (P<.05). The type of provisional material did not significantly affect the shear bond strength, with or without surface treatment. Group AbBisGMA demonstrated the lowest mean value (3.49 MPa) compared to the other groups. CONCLUSIONS: Airborne-particle abrasion and @entity1 -coating treatment did not improve the bond between grooved @entity0 alloy temporary cylinders and provisional veneering materials. It weakened the provided mechanical retention, especially when it was used with BisGMA veneering material. Material choice, whether it was @entity2 or @entity3 , did not make a statistically significant difference.

title: The effects of an airborne-particle abrasion and XXXX -coating on the bond strength between grooved @entity0 alloy temporary cylinders and provisional veneering materials.

answer: @entity1


abstract: STUDY DESIGN: Vertebral endplate tissues were obtained from @entity0 with degenerated lumbar disc classified as Modic type 1 or type 2 and investigated with immunohistochemical staining and the DNA nick end labelling techniques. OBJECTIVE: To examine the expression of fas receptor (FasR) and apoptosis in the endplate cells isolated from @entity0 with @entity2 and to see whether they are associated with the pathological change of endplate. METHODS: Fifty-six degenerated lumbar endplate specimens were obtained from the @entity0 with @entity2 categorized as type Modic I or II in magnetic resonance imaging (MRI) and eight nondegenerated specimens as control (vertebra burst @entity1 @entity0 without @entity2 in MRI) during surgical procedures. Immunohistochemical staining was performed to determine the presence of FasR and apoptosis in sections of those endplate tissues. To investigate whether the FasR expression and apoptosis in endplate were influenced by degeneration and ageing of the discs, the level of FasR expression and apoptosis in the changed and unchanged endplates was analysed. RESULTS: FasR were expressed in the cytoplasm of the endplate cells. A higher degree of FasR expression and apoptosis in endplate cells in degenerated discs was found than that in nondegenerated discs. In cell culture, the level of FasR expression and apoptosis in cells from the degenerative endplates was higher than those in unchanged endplates. The percentage of FasR-positive endplate and apoptotic endplate cells correlated significantly with the @entity0 's age (r=0.301, p<0.05; r=0.307, p<0.05. respectively), but not with the degree of @entity3 in MRI (r=0.047, p>0.05; r=0.066, p>0.05, respectively). CONCLUSION: This is the first study to compare the expression of FasR and apoptosis on vertebral endplate cells in degenerated disc with in nondegenerated disc. The results show that the endplate in degenerated disc may undergo fas-mediated apoptosis and vice versa, endplate degenerative changes may promotes apoptosis of the endplate cells within degenerated disc.

title: Expression of Fas receptor and apoptosis in vertebral endplates with XXXX categorized as Modic type I or II.

answer: @entity2


abstract: BACKGROUND: Pharmacists may improve the clinical management of major risk factors for @entity1 ( @entity1 ) prevention. A systematic review was conducted to determine the impact of pharmacist care on the management of @entity1 risk factors among outpatients. METHODS: The MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials databases were searched for randomized controlled trials that involved pharmacist care interventions among outpatients with @entity1 risk factors. Two reviewers independently abstracted data and classified pharmacists' interventions. Mean changes in blood pressure, total @entity2 , low-density lipoprotein @entity2 , and proportion of smokers were estimated using random effects models. RESULTS: Thirty randomized controlled trials (11,765 @entity0 ) were identified. Pharmacist interventions exclusively conducted by a pharmacist or implemented in collaboration with physicians or nurses included @entity0 educational interventions, @entity0 -reminder systems, measurement of @entity1 risk factors, medication management and feedback to physician, or educational intervention to health care professionals. Pharmacist care was associated with significant @entity3 (19 studies [10,479 @entity0 ]; -8.1 mm Hg [95% confidence interval {CI}, -10.2 to -5.9]/-3.8 mm Hg [95% CI,-5.3 to -2.3]); total @entity2 (9 studies [1121 @entity0 ]; -17.4 mg/L [95% CI,-25.5 to -9.2]), low-density lipoprotein @entity2 (7 studies [924 @entity0 ]; -13.4 mg/L [95% CI,-23.0 to -3.8]), and a reduction in the risk of smoking (2 studies [196 @entity0 ]; relative risk, 0.77 [95% CI, 0.67 to 0.89]). While most studies tended to favor pharmacist care compared with usual care, a substantial heterogeneity was observed. CONCLUSION: Pharmacist-directed care or in collaboration with physicians or nurses improve the management of major @entity1 risk factors in outpatients.

title: Impact of pharmacist care in the management of XXXX risk factors: a systematic review and meta-analysis of randomized trials.

answer: @entity1


abstract: OBJECTIVE: To assess function of regenerated corneal nerves in correlation with epithelial wound healing after experimental @entity0 in @entity1 treated with pigment epithelial-derived factor (PEDF) plus @entity4 ( @entity5 ). METHODS: An 8-mm stromal dissection was performed in the right eyes of adult @entity1 . Treatment with PEDF+ @entity5 was for 6 weeks. Corneal sensation was measured weekly by Cochet-Bonnet esthesiometer. After 8 weeks, immunofluorescence with bIII-tubulin, calcitonin gene-related peptide, and substance P antibodies was performed to quantify nerves. Also, @entity1 were treated with PEDF+ @entity5 for 4 weeks after lamellar keratectomy, followed by 8-mm epithelial debridement and epithelial defect assessment. One week after surgery, corneas were stained with anti-Ki67 antibody to assess cell proliferation. RESULTS: Eight weeks after surgery, calcitonin gene-related peptide-positive nerve fibers in the PEDF+ @entity5 group were similar to normal @entity1 corneas but were decreased in the vehicle. Substance P was localized in the subepithelial plexus but appeared in epithelial cells after nerve injury regardless of treatment. Five weeks after surgery, an increase in corneal sensitivity occurred in the PEDF+ @entity5 group and reached normal values by 8 weeks. Pigment epithelial-derived factor plus @entity5 increased epithelial wound healing after lamellar keratectomy. One week after epithelial injury, Ki67-positive cells increased in the limbal area. CONCLUSION: Pigment epithelial-derived factor plus @entity5 promotes regeneration of calcitonin gene-related @entity3 , accelerating wound healing and return of corneal sensitivity. CLINICAL RELEVANCE: Pigment epithelial-derived factor plus @entity5 represents a new approach to regenerate nerves and a potential treatment for prevention of severe @entity2 after surgery or diseases of the ocular surface.

title: Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus XXXX after experimental surgery.

answer: @entity4


abstract: BACKGROUND: Imaging is used as a surrogate for clinical outcome in early-phase @entity1 trials. Assessment of @entity2 growth earlier than the standard 90 days used for clinical end points may be equally accurate and more practical. OBJECTIVE: To compare assessment of the effect of reperfusion therapies using 24-hour vs day 90 magnetic resonance imaging. DESIGN: @entity2 volume was assessed on diffusion-weighted imaging (DWI) at baseline and 24 hours after @entity1 onset and on fluid-attenuated inversion recovery images at day 90. The DWI and fluid-attenuated inversion recovery lesions were manually outlined by 2 independent raters, and the volumes were averaged. Interrater consistency was assessed using the median difference in lesion volume between raters. SETTING: Referral center. @entity0   Imaging data were available for 83 @entity0 ; 77 of these @entity0 received thrombolysis. MAIN OUTCOME MEASURES: @entity2 volume at 24 hours and 90 days. RESULTS: The 24-hour DWI @entity2 volume had a strong linear correlation with day 90 fluid-attenuated inversion recovery @entity2 volume (r  =  0.98, 95% confidence interval, 0.97-0.99). Recanalization had a significant effect on @entity2 evolution between baseline and 24 hours but not between 24 hours and day 90. @entity2 growth from baseline was significantly reduced by recanalization, whether assessed at 24 hours or day 90. @entity2 volume at either time point predicted functional outcome independent of age and baseline @entity1 severity. Interrater agreement was better for DWI than fluid-attenuated inversion recovery (1.4 mL [8%] vs 1.8 mL [17%]; P  =  .002). CONCLUSIONS: Assessment of final @entity2 volume using DWI at 24 hours captures the effect of reperfusion therapies on @entity2 growth and predicts functional outcome similarly to imaging at day 90. This has the potential to reduce loss to follow-up in trials and may add early prognostic information in clinical practice.

title: Assessing response to XXXX thrombolysis: validation of 24-hour multimodal magnetic resonance imaging.

answer: @entity1


abstract: The adrenal gland in the adult is a peripheral circadian clock involved in the coordination of energy intake and expenditure, required for adaptation to the external environment. During fetal life, a peripheral circadian clock is present in the nonhuman primate adrenal gland. Whether this extends to the fetal adrenal gland like the @entity0 is unknown. Here we explored in vivo and in vitro whether the @entity0 fetal adrenal is a peripheral circadian clock entrained by @entity1 . We measured the 24-h changes in adrenal content of @entity2 and in the expression of clock genes @entity3 and @entity6 and of @entity7 ( @entity7 ), @entity4 @entity1 receptor, and @entity5 ( @entity5 ) expression. In culture, we explored whether oscillatory expression of these genes persisted during 48 h and the effect of a 4-h @entity1 pulse on their expression. In vivo, the @entity0 fetal adrenal gland showed circadian expression of @entity6 and @entity3 in antiphase (acrophases at 2200 and 1300 h, respectively) as well as of @entity4 and @entity5 . This was accompanied by circadian rhythms of @entity2 content and of @entity7 expression both peaking at 0600 h. The 24-h oscillatory expression of @entity6 , @entity3 , @entity7 , @entity4 , and @entity5 persisted during 48 h in culture; however, the antiphase between @entity3 and @entity6 was lost. The pulse of @entity1 shifted the acrophases of all the genes studied and restored the antiphase between @entity3 and @entity6 . Thus, in the @entity0 , the fetal adrenal is a strong peripheral clock potentially amenable to regulation by maternal @entity1 .

title: A circadian clock entrained by XXXX is ticking in the @entity0 fetal adrenal.

answer: @entity1


abstract: The adrenal gland in the adult is a peripheral circadian clock involved in the coordination of energy intake and expenditure, required for adaptation to the external environment. During fetal life, a peripheral circadian clock is present in the nonhuman primate adrenal gland. Whether this extends to the fetal adrenal gland like the @entity0 is unknown. Here we explored in vivo and in vitro whether the @entity0 fetal adrenal is a peripheral circadian clock entrained by @entity1 . We measured the 24-h changes in adrenal content of @entity2 and in the expression of clock genes @entity3 and @entity6 and of @entity7 ( @entity7 ), @entity4 @entity1 receptor, and @entity5 ( @entity5 ) expression. In culture, we explored whether oscillatory expression of these genes persisted during 48 h and the effect of a 4-h @entity1 pulse on their expression. In vivo, the @entity0 fetal adrenal gland showed circadian expression of @entity6 and @entity3 in antiphase (acrophases at 2200 and 1300 h, respectively) as well as of @entity4 and @entity5 . This was accompanied by circadian rhythms of @entity2 content and of @entity7 expression both peaking at 0600 h. The 24-h oscillatory expression of @entity6 , @entity3 , @entity7 , @entity4 , and @entity5 persisted during 48 h in culture; however, the antiphase between @entity3 and @entity6 was lost. The pulse of @entity1 shifted the acrophases of all the genes studied and restored the antiphase between @entity3 and @entity6 . Thus, in the @entity0 , the fetal adrenal is a strong peripheral clock potentially amenable to regulation by maternal @entity1 .

title: A circadian clock entrained by @entity1 is ticking in the XXXX fetal adrenal.

answer: @entity0


abstract: OBJECTIVE: To critically appraise the validity of activity indices used in the followup of @entity0 with undifferentiated @entity1 (UPIA). METHODS: A systematic review was performed in Medline, Embase, the Cochrane Library, and abstracts presented at the 2007 and 2008 meetings of the American College of Rheumatology and European League Against @entity2 . Selection criteria were: @entity0 with UPIA, the assessment of instruments to evaluate disease activity, and assessment of validity of the instruments. Two reviewers screened titles and abstracts independently and collected data using ad hoc standard forms. RESULTS: The search yielded 179 articles and 834 abstracts, of which 4 articles and 1 abstract were included. We found no study that validated Disease Activity Score (DAS), Clinical Disease Activity Index (CDAI), or Simplified Disease Activity Index (SDAI). Included studies addressed validation of 4 questionnaires: WHO Disability Assessment Schedule (WHODAS), London Handicap Scale (LHS), Disease Repercussion Profile (DRP), and the Health Assessment Questionnaire (HAQ); and 3 indexes: RA Disease Activity Index (RADAI), McGill Range of Motion Index (McROMI), and NOAR Damaged Joint Count (NOAR-DJC). Questionnaires were self-administered and feasible; RADAI was the most feasible index. Internal consistency was studied in the questionnaires (Cronbach's a > 0.83). @entity4 was tested in the DRP, LHS, and HAQ, but the approach to study sensitivity to change was poorly explained, with no clear intervention. @entity3 , examined by means of convergence with other instruments, was generally moderate, and slightly higher for the RADAI. CONCLUSION: No instrument of disease activity has been fully validated for use in UPIA. We found no direct evidence of what is the most useful index to follow up @entity0 with UPIA.

title: Clinical composite measures of disease activity for diagnosis and followup of undifferentiated XXXX : a systematic review.

answer: @entity1


abstract: PURPOSE: To determine if @entity6 have an increased and sustained level of inflammatory immune mediators in the vitreous compared to phakic eyes. METHODS: Vitreous fluid samples were obtained from 73 @entity0 undergoing elective pars plana vitrectomy ( @entity7 ) as a result of a macular hole, epiretinal membrane, vitreous macular traction, or vitreous floaters. Forty eyes were pseudophakic and had previously undergone uncomplicated @entity2 surgery, ranging from a few months to several years prior to @entity7 . The vitreous samples were analyzed for 29 different inflammatory immune mediators using multiplex bead immunoassays. RESULTS: A total of 14 cytokines (eotaxin, @entity3 [ @entity3 ], @entity8 [ @entity8 ], @entity15 [MDC], @entity12 , @entity13 , thymus activation regulated chemokine [ @entity14 ], IL-12p40, @entity11 , @entity16 , @entity10 , @entity1 , @entity4 , and @entity5 ) were detected in the vitreous of both study groups. Using multiple linear regression analysis, @entity9 was significantly correlated with higher levels of vitreous immune mediators compared to phakia. Elevated vitreous levels were estimated to decrease over time for @entity4 , @entity5 , @entity11 , @entity16 , and @entity1 , though they remained elevated for many months and even years compared to the levels detected in phakic eyes. CONCLUSIONS: This is the first study to demonstrate that @entity2 surgery and @entity9 can induce increased vitreous levels of a substantial range of inflammatory immune mediators. The elevated levels seem to be maintained for a long period of time. These increased levels of cytokines may be involved in inflammatory processes leading to several complications to @entity2 surgery, both early and late.

title: Increased levels of inflammatory immune mediators in vitreous from XXXX .

answer: @entity6


abstract: BACKGROUND: The objective of this study was determine the frequency of bloodstream infections (BSIs) and the causative bacteria and their resistance patterns in @entity0 with @entity7 ( @entity7 ) in a large tertiary care university hospital in @entity1 over a 5-year period. METHODS: A total of 2098 @entity0 with @entity7 with 3703 @entity5 episodes were included. @entity0 were classified as high-risk (n = 843) and low-risk (n = 1255) groups and evaluated for frequency of BSIs, causative bacteria, and their resistance patterns. RESULTS: The frequency of BSIs was 14.5%. The frequency of gram-negative BSIs in high-risk and low-risk groups was 10.7% and 5.4% (p < 0.001), respectively. The frequency of gram-positive BSIs in high-risk and low-risk groups was 7.0% and 3.9% (p < 0.001), respectively. Gram-negative bacteria predominated (52.6%), with @entity2 (17.3%) and @entity9 @entity11 . (11.0%) as the most frequent organisms. Coagulase-negative staphylococci (10.4%) and Corynebacterium @entity11 . (6.3%) were the most common gram-positive bacteria (35.8%). The rate of @entity12 (ESBL) production was 45% for @entity2 and 58% for @entity9 @entity11 . @entity6 resistance was 58% for @entity2 and 11% for @entity9 @entity11 .. The overall frequency of @entity10 resistance in @entity4 was 28%, and 87% of Acinetobacter @entity11 . were multidrug-resistant. Of @entity3 isolates, 24.8% were resistant to @entity8 . CONCLUSION: The dominating causes of BSIs in @entity0 with @entity7 in our hospital are resistant gram-negative bacteria, which has made empirical antimicrobial choice a highly challenging issue in this @entity0 population.

title: Epidemiology and emerging resistance in bacterial bloodstream infections in @entity0 with XXXX .

answer: @entity7


abstract: BACKGROUND: The objective of this study was determine the frequency of bloodstream infections (BSIs) and the causative bacteria and their resistance patterns in @entity0 with @entity7 ( @entity7 ) in a large tertiary care university hospital in @entity1 over a 5-year period. METHODS: A total of 2098 @entity0 with @entity7 with 3703 @entity5 episodes were included. @entity0 were classified as high-risk (n = 843) and low-risk (n = 1255) groups and evaluated for frequency of BSIs, causative bacteria, and their resistance patterns. RESULTS: The frequency of BSIs was 14.5%. The frequency of gram-negative BSIs in high-risk and low-risk groups was 10.7% and 5.4% (p < 0.001), respectively. The frequency of gram-positive BSIs in high-risk and low-risk groups was 7.0% and 3.9% (p < 0.001), respectively. Gram-negative bacteria predominated (52.6%), with @entity2 (17.3%) and @entity9 @entity11 . (11.0%) as the most frequent organisms. Coagulase-negative staphylococci (10.4%) and Corynebacterium @entity11 . (6.3%) were the most common gram-positive bacteria (35.8%). The rate of @entity12 (ESBL) production was 45% for @entity2 and 58% for @entity9 @entity11 . @entity6 resistance was 58% for @entity2 and 11% for @entity9 @entity11 .. The overall frequency of @entity10 resistance in @entity4 was 28%, and 87% of Acinetobacter @entity11 . were multidrug-resistant. Of @entity3 isolates, 24.8% were resistant to @entity8 . CONCLUSION: The dominating causes of BSIs in @entity0 with @entity7 in our hospital are resistant gram-negative bacteria, which has made empirical antimicrobial choice a highly challenging issue in this @entity0 population.

title: Epidemiology and emerging resistance in bacterial bloodstream infections in XXXX with @entity7 .

answer: @entity0


abstract: OBJECTIVE: To investigate the effect of antifreeze protein (AFP) supplementation during @entity0 oocyte vitrification on the survival, fertilization and embryonic development. DESIGN: Animal study. SETTING: University laboratory. ANIMAL(S): BDF-1 @entity0 . INTERVENTION(S): In  vivo-matured metaphase II oocytes were vitrified with the use of CryoTop by two-step exposure to equilibrium and vitrification solution supplemented or not with 500 ng/mL AFP III. MAIN OUTCOME MEASURE(S): Postwarming survival, fertilization, embryonic development up to blastocyst in  vitro, morphology of spindle and chromosome, membrane integrity, @entity1 ( @entity1 ) contents, and several gene expressions. RESULT(S): In the AFP-treated group, blastocyst formation rate was significantly higher and blastomere count with positive caspase was significantly lower compared with the nontreated group. Rate of intact spindle/chromosome, stable membrane, and @entity1 contents were significantly higher in AFP group. AFP group showed higher @entity6 and lower @entity9 gene expression. Both vitrification groups showed increased @entity5 , @entity8 , and @entity2 / @entity3 expression and decreased @entity7 and @entity4 expression compared with fresh control samples. CONCLUSION(S): Supplementation of AFP in vitrification medium has a protective effect on @entity0 oocytes for chilling injury; it can preserve spindle/membrane integrity and intracellular @entity1 contents. More stable spindle integrity in the AFP group may be associated with higher @entity6 and lower @entity9 gene expression.

title: Effect of antifreeze protein supplementation in vitrification medium on XXXX oocyte developmental competence.

answer: @entity0


abstract: Meiotic errors during oocyte maturation are considered the major contributors to embryonic @entity2 in @entity0 IVF treatment. Various technologies have been developed to screen polar bodies, blastomeres and trophectoderm cells for chromosomal aberrations. Array-CGH analysis using bacterial artificial chromosome (BAC) arrays is widely applied for preimplantation genetic diagnosis (PGD) using single cells. Recently, an increase in the pregnancy rate has been demonstrated using array-CGH to evaluate trophectoderm cells. However, in some countries, the analysis of embryonic cells is restricted by law. Therefore, we used BAC array-CGH to assess the impact of polar body analysis on the live birth rate. A disadvantage of polar body aneuploidy screening is the necessity of the analysis of both the first and second polar bodies, resulting in increases in costs for the @entity0 and complex data interpretation. Aneuploidy screening results may sometimes be ambiguous if the first and second polar bodies show reciprocal chromosomal aberrations. To overcome this disadvantage, we tested a strategy involving the pooling of DNA from both polar bodies before DNA amplification. We retrospectively studied 351 @entity0 , of whom 111 underwent polar body array-CGH before embryo transfer. In the group receiving pooled polar body array-CGH (aCGH) analysis, 110 embryos were transferred, and 29 babies were born, corresponding to live birth rates of 26.4% per embryo and 35.7% per @entity0 . In contrast, in the control group, the IVF treatment was performed without @entity1 ( @entity1 ). For this group, 403 embryos were transferred, and 60 babies were born, resulting in live birth rates of 14.9% per embryo and 22.7% per @entity0 . In conclusion, our data show that in the aCGH group, the use of aneuploidy screening resulted in a significantly higher live birth rate compared with the control group, supporting the benefit of @entity1 for IVF couples in addition to the suitability and effectiveness of our polar body pooling strategy.

title: Increasing live birth rate by XXXX of pooled polar bodies using array comparative genomic hybridization.

answer: @entity1


abstract: PURPOSE: To report early clinical outcomes of high-dose-rate interstitial image-guided brachytherapy (BT) in the definitive management of locally advanced cervical @entity2 . METHODS: We retrospectively analyzed 31 locally advanced cervical @entity2 @entity0 treated at our institution between January 2010 and April 2013. About 88% had advanced disease based on the International Federation of Gynecology and Obstetrics guidelines, and 87% received concurrent chemotherapy. All @entity0 were treated with external beam radiation therapy to a median dose of 45  Gy (range, 39.6-58  Gy) before receiving BT. High-dose-rate BT was delivered in a single implant to a median dose of 6  Gy * five fractions to a CT-defined volume. Median total equivalent 2-Gy dose, dose covered by 90% of the high-risk clinical target volume (HR-CTV D90), and HR-CTV were 84, 87.4, and 49.9 cc, respectively. Kaplan-Meier method was used for actuarial survival analysis, and @entity3 was graded using Common Terminology Criteria for Adverse Events, version 4.0. RESULTS: Median followup was 19.3  months. Two-year actuarial local control, regional control, and @entity1 ( @entity1 ) were 90%, 93%, and 23.6%, respectively. Two-year disease-free survival was 55%. Genitourinary, gastrointestinal, or gynecologic Grade 3 @entity3 was seen in 5 @entity0 (3 T4a and 2 T3b) for crude rates of 13%, 7%, and 3%, respectively. Stratifying HR-CTV by <30 and >30 cc and then by HR-CTV D90 of <85, 85-90, and >90  Gy showed that 100% of the local failures, regional failures, @entity1 , and G3 @entity3 occurred in >30 cc group. The rate of @entity1 was also significantly higher in the >30 cc group (p  =  0.036). CONCLUSIONS: An interstitial approach can achieve excellent outcomes in cases where intracavitary and/or hybrid approaches are either not suitable or not available.

title: Early clinical outcomes of ultrasound-guided CT-planned high-dose-rate interstitial brachytherapy for primary locally advanced cervical XXXX .

answer: @entity2


abstract: The monogamous prairie @entity2 to early pharmacological manipulation in a number of species-typical social behaviors. The long-term consequences of altering the neonatal @entity3 system are not well characterized. This study examined whether early manipulation of the @entity3 system, a known mediator of adult prairie vole social behavior, during neonatal development would affect adult aggressive and @entity1 . Eight-day-old pups were given a single treatment with either 1 mg/kg of @entity4 (D1 agonist), @entity6 (D2 agonist), @entity5 (D1 antagonist), @entity7 (D2 antagonist), or saline vehicle. As adults, animals received tests for @entity1 and partner preference. Activation of D1-like receptors in @entity0 partner preference formation, but had no effect on aggression. Other neonatal treatments had no effect on their behavior as adults. To determine whether D1 activation in pups induced changes in @entity3 receptor expression, we performed autoradiography on striatal tissue from a second cohort of saline-treated and @entity4 -treated animals. Although sex differences were observed, we found no treatment differences in D1 or D2 receptor binding in any striatal subregion. This study shows that exposure to a single early pharmacological alteration of @entity3 receptor activity may have long-term effects on the social behavior of prairie voles.

title: Neonatal exposure to the D1 agonist XXXX inhibits pair bonding in the adult prairie vole.

answer: @entity4


abstract: BACKGROUND: Neonates with @entity2 ( @entity2 ) are at high risk for @entity3 ( @entity3 ). @entity6 -based intravenous lipid emulsions (S-ILE) have been associated with @entity3 . This study's objective was to determine if a lower dose compared with a higher dose of S-ILE prevents @entity5 without compromising growth. MATERIALS AND METHODS: This multicenter randomized controlled pilot study enrolled @entity0 with @entity2 who were  <=5 days of age to a low dose (~1 g/kg/d) (LOW) or control dose of S-ILE (~3 g/kg/d) (CON). The primary outcome was @entity5 (direct @entity4 [DB] >2 mg/dL) after the first 7 days of age. Secondary outcomes included growth, @entity7 duration, and late-onset @entity1 . RESULTS: Baseline characteristics were similar between the LOW (n = 20) and CON groups (n = 16). When the LOW group was compared with the CON group, there was no difference in @entity5 (30% vs 38%, P = .7) or secondary outcomes. However, mean    SE DB rate of change over the first 8 weeks (0.07    0.04 vs 0.3    0.09 mg/dL/wk, P = .01) and entire study (0.008    0.03 vs 0.2    0.07 mg/dL/wk, P = .02) was lower in the LOW group compared with the CON group. CONCLUSION: In neonates with @entity2 who received a lower dose of S-ILE, DB increased at a slower rate in comparison to neonates who received a higher dose of S-ILE. Growth was comparable between the groups. This study demonstrates a need for a larger, randomized controlled trial comparing 2 different S-ILE doses for @entity5 prevention in neonates at risk for @entity3 .

title: Low-Dose Parenteral XXXX Oil for the Prevention of Parenteral Nutrition-Associated @entity3 in Neonates With @entity2 : A Multicenter Randomized Controlled Pilot Study.

answer: @entity6


abstract: BACKGROUND: Neonates with @entity2 ( @entity2 ) are at high risk for @entity3 ( @entity3 ). @entity6 -based intravenous lipid emulsions (S-ILE) have been associated with @entity3 . This study's objective was to determine if a lower dose compared with a higher dose of S-ILE prevents @entity5 without compromising growth. MATERIALS AND METHODS: This multicenter randomized controlled pilot study enrolled @entity0 with @entity2 who were  <=5 days of age to a low dose (~1 g/kg/d) (LOW) or control dose of S-ILE (~3 g/kg/d) (CON). The primary outcome was @entity5 (direct @entity4 [DB] >2 mg/dL) after the first 7 days of age. Secondary outcomes included growth, @entity7 duration, and late-onset @entity1 . RESULTS: Baseline characteristics were similar between the LOW (n = 20) and CON groups (n = 16). When the LOW group was compared with the CON group, there was no difference in @entity5 (30% vs 38%, P = .7) or secondary outcomes. However, mean    SE DB rate of change over the first 8 weeks (0.07    0.04 vs 0.3    0.09 mg/dL/wk, P = .01) and entire study (0.008    0.03 vs 0.2    0.07 mg/dL/wk, P = .02) was lower in the LOW group compared with the CON group. CONCLUSION: In neonates with @entity2 who received a lower dose of S-ILE, DB increased at a slower rate in comparison to neonates who received a higher dose of S-ILE. Growth was comparable between the groups. This study demonstrates a need for a larger, randomized controlled trial comparing 2 different S-ILE doses for @entity5 prevention in neonates at risk for @entity3 .

title: Low-Dose Parenteral @entity6 Oil for the Prevention of Parenteral Nutrition-Associated XXXX in Neonates With @entity2 : A Multicenter Randomized Controlled Pilot Study.

answer: @entity3


abstract: BACKGROUND: Neonates with @entity2 ( @entity2 ) are at high risk for @entity3 ( @entity3 ). @entity6 -based intravenous lipid emulsions (S-ILE) have been associated with @entity3 . This study's objective was to determine if a lower dose compared with a higher dose of S-ILE prevents @entity5 without compromising growth. MATERIALS AND METHODS: This multicenter randomized controlled pilot study enrolled @entity0 with @entity2 who were  <=5 days of age to a low dose (~1 g/kg/d) (LOW) or control dose of S-ILE (~3 g/kg/d) (CON). The primary outcome was @entity5 (direct @entity4 [DB] >2 mg/dL) after the first 7 days of age. Secondary outcomes included growth, @entity7 duration, and late-onset @entity1 . RESULTS: Baseline characteristics were similar between the LOW (n = 20) and CON groups (n = 16). When the LOW group was compared with the CON group, there was no difference in @entity5 (30% vs 38%, P = .7) or secondary outcomes. However, mean    SE DB rate of change over the first 8 weeks (0.07    0.04 vs 0.3    0.09 mg/dL/wk, P = .01) and entire study (0.008    0.03 vs 0.2    0.07 mg/dL/wk, P = .02) was lower in the LOW group compared with the CON group. CONCLUSION: In neonates with @entity2 who received a lower dose of S-ILE, DB increased at a slower rate in comparison to neonates who received a higher dose of S-ILE. Growth was comparable between the groups. This study demonstrates a need for a larger, randomized controlled trial comparing 2 different S-ILE doses for @entity5 prevention in neonates at risk for @entity3 .

title: Low-Dose Parenteral @entity6 Oil for the Prevention of Parenteral Nutrition-Associated @entity3 in Neonates With XXXX : A Multicenter Randomized Controlled Pilot Study.

answer: @entity2


abstract: BACKGROUND: @entity3 ( @entity3 ) may progress into fully developed @entity1 with a relatively high risk of metastasizing and therefore requires early identification and treatment. OBJECTIVES: To assess the clinical and histological long-term outcome as well as the safety and tolerability of sequential use of photodynamic therapy (PDT) and imiquimod in @entity3 . METHODS: @entity0 with histologically confirmed grade 1 and 2 @entity3 received two @entity4 - @entity2 sessions 2weeks apart. After a 2-week rest period the @entity0 started applying imiquimod 5% cream 3days per week for 4weeks. At the first follow-up visits at 3 and 6months, noncomplete clinical responders were biopsied and excluded from the study if histological alterations were indicative for @entity3 . At the last 12-month follow-up all remaining @entity0 were biopsied. Adverse events were noted at weeks 2, 4, 6 and 8 of the treatment phase and at every visit of the follow-up period. RESULTS: Of the 34 enrolled @entity0 , 30 completed the study. Complete clinical response was achieved by 27 @entity0 in 3months. At 6months, clinical and histological recurrence occurred in two @entity0 , while at 12months the complete clinical cure rate obtained was 80% and the histological complete cure rate was 73%. Treatment was well tolerated and adverse events were as expected and transient. CONCLUSION: Sequential use of PDT and imiquimod cream is of significant benefit for the treatment of @entity3 . Further studies are needed in order to confirm the improved outcome using the combination treatment, to clarify the involved mechanisms and to optimize the therapeutic protocol.

title: Sequential use of photodynamic therapy and imiquimod 5% cream for the treatment of XXXX : a 12-month follow-up study.

answer: @entity3


abstract: AIM: To determine the safety and usefulness of conization with an electrosurgical loop (the loop electrosurgical excision procedure [LEEP]) in young @entity0 with @entity4 ( @entity4 ) of the uterine cervix. METHODS: A retrospective medical chart review of five @entity0 with @entity4 initially treated with LEEP conization between 2002 and 2010 and who later experienced recurrence in the form of invasive or advanced disease was conducted. RESULTS: The median @entity0 age at initial LEEP conization was 41years (33-56years). The margin status in conization specimens was positive in three of the five @entity0 . The median time to detection of @entity2 progression was 50months (17-58months). Magnetic resonance imaging was effective in detecting @entity2 recurrence in all cases. In four @entity0 , hysterectomy was performed to treat the recurrence; these four @entity0 are currently alive and disease-free. One @entity0 with cervical lymph nodes and bone @entity1 was treated with chemotherapy alone; however, the @entity0 died. In surgical specimens, @entity2 progression was observed extending toward the endometrium in all five @entity0 and toward the vagina in two @entity0 . CONCLUSION:     This study indicates that @entity0 with @entity4 occasionally show unexpected @entity2 progression after conization and the progression could be life-threatening. @entity3 often shows @entity2 progression toward the endometrium or vagina, leading to difficulties in its detection at periodic pelvic examinations.

title: Unexpected @entity2 progression after conization for XXXX of the uterine cervix.

answer: @entity4


abstract: AIM: To determine the safety and usefulness of conization with an electrosurgical loop (the loop electrosurgical excision procedure [LEEP]) in young @entity0 with @entity4 ( @entity4 ) of the uterine cervix. METHODS: A retrospective medical chart review of five @entity0 with @entity4 initially treated with LEEP conization between 2002 and 2010 and who later experienced recurrence in the form of invasive or advanced disease was conducted. RESULTS: The median @entity0 age at initial LEEP conization was 41years (33-56years). The margin status in conization specimens was positive in three of the five @entity0 . The median time to detection of @entity2 progression was 50months (17-58months). Magnetic resonance imaging was effective in detecting @entity2 recurrence in all cases. In four @entity0 , hysterectomy was performed to treat the recurrence; these four @entity0 are currently alive and disease-free. One @entity0 with cervical lymph nodes and bone @entity1 was treated with chemotherapy alone; however, the @entity0 died. In surgical specimens, @entity2 progression was observed extending toward the endometrium in all five @entity0 and toward the vagina in two @entity0 . CONCLUSION:     This study indicates that @entity0 with @entity4 occasionally show unexpected @entity2 progression after conization and the progression could be life-threatening. @entity3 often shows @entity2 progression toward the endometrium or vagina, leading to difficulties in its detection at periodic pelvic examinations.

title: Unexpected XXXX progression after conization for @entity4 of the uterine cervix.

answer: @entity2


abstract: INTRODUCTION: Because of better treatment of chronic @entity2 , @entity0 with multiple @entity1 insults are living longer and requiring long-term management. Electrocardiograms (ECGs) in @entity0 with multiple @entity3 (MMIs) are a challenge to the clinician or cardiologist. This is because second @entity3 ( @entity3 ) often modify or obscure the ECG effects of the first MI and vice versa. This can result in complex tracings, which are difficult to interpret and predict the locations of damaged regions. It is important to identify MMI because, additively, they can result in poor ventricular function. METHODS: New criteria for the diagnosis of MMI were derived from studies in which ECGs and body surface potential distribution maps were correlated with @entity5 in animal studies of MI and in @entity0 at the time of coronary artery bypass graft and with the pathologic anatomy in a few @entity0 . The initial criteria were fine tuned by correlations between ECGs and independent data obtained from catheterization and other imaging modalities (ultrasound and radionuclide single photon emission computed tomography). RESULTS: Often 2 or more @entity3 are concealed according to classical Q- and R-wave criteria. @entity3 located in opposing walls (180  ), that is, inferior-superior, anterior-posterior, are the most difficult to identify. Two @entity3 that are not opposing (90  ) are usually readily detectable. The pathologic Q waves produced by each separate MI, when opposing, are replaced by multiple QRS deflections or baseline crossings, which are referred to as M and W complexes. These waveforms replace Q waves and are equally weighted in a scoring system to improve diagnostic accuracy of ECG interpretation. These new criteria can also be used to predict @entity3 in left @entity4 , intraventricular conduction delay, and ventricular pacing. CONCLUSION: Multiple @entity3 modify the ECG because they eliminate Q waves and result in confusing, splintered QRS waveforms, referred to as M and W complexes. New criteria are presented to diagnose the presence and locations of these MMIs, which predict reduced left ventricular function, in normal sinus rhythm, left @entity4 , and ventricular pacing.

title: Diagnosis of multiple infarcts from complex electrocardiograms during normal rhythm, left XXXX , and ventricular pacing.

answer: @entity4


abstract: The prevalence and impact of the overexpression of AmpC and efflux pumps were evaluated with a collection of 190 @entity0 isolates recovered from bloodstream infections in a 2008 multicenter study (10 hospitals) in Spain. The MICs of a panel of 13 antipseudomonal agents were determined by microdilution, and the expressions of ampC, mexB, mexY, mexD, and mexF were determined by real-time reverse transcription (RT)-PCR. Up to 39% of the isolates overexpressed at least one of the mechanisms. ampC overexpression (24.2%) was the most prevalent mechanism, followed by mexY (13.2%), mexB (12.6%), mexF (4.2%), and mexD (2.2%). The overexpression of mexB plus mexY, documented for 5.3% of the isolates, was the only combination showing a significantly (P=0.02) higher prevalence than expected from the frequencies of the individual mechanisms (1.6%). Additionally, all @entity3 -resistant isolates studied (25 representative isolates) showed inactivating mutations in oprD. Most of the isolates nonsusceptible to @entity4 - @entity7 (96%) and @entity5 (84%) overexpressed ampC, while mexB (25%) and mexY (29%) overexpressions gained relevance among @entity6 -nonsusceptible isolates. Nevertheless, the prevalence of mexY overexpression was highest among @entity2 -nonsusceptible isolates (37%), and that of mexB was highest among meropenem-nonsusceptible isolates (33%). Regarding @entity1 -resistant isolates, besides the expected increased prevalence of efflux pump overexpression, a highly significant link to ampC overexpression was documented for the first time: up to 52% of @entity1 -nonsusceptible isolates overexpressed ampC, sharply contrasting with the 24% documented for the complete collection (P<0.001). In summary, mutation-driven resistance was frequent in @entity0 isolates from bloodstream infections, whereas metallo-b-lactamases, detected in 2 isolates (1%) producing @entity8 , although with increasing prevalences, were still uncommon.

title: Overexpression of AmpC and efflux pumps in XXXX isolates from bloodstream infections: prevalence and impact on resistance in a Spanish multicenter study.

answer: @entity0


abstract: BACKGROUND: @entity5 is associated with a variety of @entity2 and medical illnesses. Very little research is available on the syndrome and the exact neurobiological correlates are not known. Though various cortical and subcortical circuits are implicated in the pathogenesis, the role of cerebellum is unknown. We report an unusual presentation of herpes simplex @entity3 , clinically as @entity7 and radiologically as isolated symmetrical cerebellar involvement affecting the posterior cerebellum. We discuss the possible role of the cerebellum in producing a @entity6 state. CASE REPORT: We describe the clinical presentation of @entity5 in a 19-year-old @entity0 with herpes simplex @entity3 . Her magnetic reasonance imaging showed features of @entity4 involving the posterior cerebellum with hemorrhagic transformation. She lacked the classical frontotemporal involvement of herpes and recovered completely without physical or neuropsychological sequelae. She did not show signs associated with @entity1 at any point during the illness. CONCLUSIONS: This case provides compelling evidence for the possible role of the posterior cerebellum in the clinical presentation of @entity5 . This is probably related to its role in controlling the nonmotor cerebral functions through corticocerebellar connections. Further studies of @entity6 syndromes are needed to establish this association.

title: Insights from a rare clinical presentation of herpes simplex @entity3 : adding to the XXXX ?

answer: @entity6


abstract: BACKGROUND: @entity5 is associated with a variety of @entity2 and medical illnesses. Very little research is available on the syndrome and the exact neurobiological correlates are not known. Though various cortical and subcortical circuits are implicated in the pathogenesis, the role of cerebellum is unknown. We report an unusual presentation of herpes simplex @entity3 , clinically as @entity7 and radiologically as isolated symmetrical cerebellar involvement affecting the posterior cerebellum. We discuss the possible role of the cerebellum in producing a @entity6 state. CASE REPORT: We describe the clinical presentation of @entity5 in a 19-year-old @entity0 with herpes simplex @entity3 . Her magnetic reasonance imaging showed features of @entity4 involving the posterior cerebellum with hemorrhagic transformation. She lacked the classical frontotemporal involvement of herpes and recovered completely without physical or neuropsychological sequelae. She did not show signs associated with @entity1 at any point during the illness. CONCLUSIONS: This case provides compelling evidence for the possible role of the posterior cerebellum in the clinical presentation of @entity5 . This is probably related to its role in controlling the nonmotor cerebral functions through corticocerebellar connections. Further studies of @entity6 syndromes are needed to establish this association.

title: Insights from a rare clinical presentation of herpes simplex XXXX : adding to the @entity6 ?

answer: @entity3


abstract: INTRODUCTION: High weight and high percent mammographic breast density are both @entity0 risk factors, but are negatively correlated. Therefore we wanted to obtain more insight in this apparent paradox. METHODS: We investigated in a longitudinal study how weight change over menopause is related to changes in mammographic breast features. 591 @entity1 of the EPIC-NL cohort, were divided into 3 groups according their prospectively measured weight change over menopause: 1) @entity2 (> -3.0  %), 2) stable weight (between -3.0  % and +3.0  %) and 3) @entity3 (>3.0  %). SPSS GLM univariate analysis was used to determine both the mean breast measure changes in, and the trend over the weight change groups. RESULTS: Over a median period of 5  years, the mean change in percentage density in these groups was -5.0  % (95  % CI: -8.0; -2.1), -6.8  % (95  % CI: -9.0; -4.5) and -10.2  % (95  % CI: -12.5; -7.9), respectively (p-trend   =   0.001). The mean change in dense area was -16.7  cm(2) (95  % CI: -20.1; -13.4), -16.4  cm(2) (95  % CI: -18.9; -13.9) and -18.1  cm(2) (95  % CI: -20.6; -15.5), respectively (p-trend   =   0.437). Finally, the mean change in nondense area was -6.1  cm(2) (95  % CI: -11.9; -0.4), -0.6  cm(2) (95  % CI: -4.9; 3.8) and 5.3  cm(2) (95  % CI: 0.9; 9.8), respectively (p-trend   <   0.001). CONCLUSIONS: Going through menopause is associated with a decrease in both percent density and dense area. The decrease in percent density is largest in @entity1 who gain weight, due to an increase in the nondense tissue. The decrease in dense area is not related to weight change. So the fact that both high percent density and high weight or @entity3 are associated with high @entity0 risk, can probably not be explained by an increase (or slower decrease) of dense area in @entity1 gaining weight compared to @entity1 losing weight or staying stable weight. These results suggest that weight and dense area are presumably two independent @entity0 risk factors.

title: The effect of weight change on changes in breast density measures over menopause in a XXXX screening cohort.

answer: @entity0


abstract: Real-time ultrasound perfusion imaging (rt-UPI) allows visualization of microbubbles flowing through the cerebral microvasculature. We hypothesized that analysis of microbubble tissue replenishment would enable for characterization of perfusion deficits in @entity2 . Twenty-three @entity0 (mean age 70.2    13.2 years, 9 weeks) were included. Sequential images of bubble replenishment were acquired by transcranial rt-UPI at low mechanical index immediately after microbubble destruction. Different parameters were calculated from regions of interest (ROIs): real-time time to peak (rt-TTP), rise rate (b), and plateau (A) of acoustic intensity, and A   b was used as an index of blood flow. Results were compared with diffusion-weighted and perfusion magnetic resonance imaging. Parameters of rt-UPI had lower values in ROIs of @entity1 as compared with normal tissue (b=0.58    0.40 versus 1.25    0.83; P=0.001; A=1.44    1.75 versus 2.63    2.31; P=0.05; A   b=1.14    2.25 versus 2.98    2.70; P=0.01). Real-time time to peak was delayed in @entity1 tissue (11.43    2.67 versus 8.88    1.66 seconds; P<0.001). From the analysis of receiver operating characteristic curves, b and A   b had the largest areas under the curve with optimal cutoff values of b<0.76 and A   b<1.91. We conclude that rt-UPI with analysis of microbubble replenishment correctly identifies @entity1 brain tissue in acute @entity2 .

title: Real-time ultrasound brain perfusion imaging with analysis of microbubble replenishment in acute XXXX .

answer: @entity2


abstract: UNASSIGNED: It is well established that @entity2 at different frequencies interact with each other in terms of cross-frequency coupling (CFC). In particular, the phase of slower oscillations modulates the power of faster oscillations. This is referred to as phase-amplitude coupling (PAC). Examples are alpha phase to gamma power coupling as observed in @entity0 and theta phase to gamma power coupling as observed in the @entity1 hippocampus. We here ask if the interaction between alpha and gamma oscillations is in the direction of the phase of slower oscillations driving the power of faster oscillations or conversely from the power of faster oscillations driving the phase of slower oscillations. To answer this question, we introduce a new measure to estimate the @entity3 ( @entity3 ). This measure is based on the phase-slope index (PSI) between the phase of slower oscillations and the power envelope of faster oscillations. Further, we propose a randomization framework for statistically evaluating the coupling measures when controlling for multiple comparisons over the investigated frequency ranges. The method was firstly validated on simulated data and next applied to resting state electrocorticography (ECoG) data. These results demonstrate that the method works reliably. In particular, we found that the power envelope of gamma oscillations drives the phase of slower oscillations in the alpha band. This surprising finding is not easily reconcilable with theories suggesting that feedback controlled alpha oscillations modulate feedforward processing reflected in the gamma band.

title: Measuring directionality between XXXX of different frequencies.

answer: @entity2


abstract: BACKGROUND: Biomarkers such as serum @entity2 , anion gap (AG), and base excess (BE) have been shown to be of use in determining shock in @entity0 with seemingly normal vital signs. We seek to determine if these biomarkers can be used interchangeably in @entity0 with @entity1 in the emergency setting based on their test characteristics and correlation to each other. METHODS: A prospective observational cohort study was undertaken at an urban level 1 @entity1 center. Baseline vital signs, point-of-care BE, AG, and serum @entity2 were recorded in all @entity0 who presented for @entity1 . Correlation was determined by linear regression model. Overall test characteristics and relative risk were calculated. RESULTS: One hundred @entity0 were enrolled. The median age was 30 years (interquartile range, 24-42 years), and 89% were male. Fifty-three percent of injuries were @entity1 . Pearson correlation of serum @entity2 to BE was -0.81 (r(2) = 0.66; 95% confidence interval [CI], 0.53-0.75; P < .001), that of BE to AG was -0.71 (r(2) = 0.5; 95% CI, -0.80 to -0.57; P < .01), and that for serum @entity2 to AG was 0.71 (r(2) = 0.5; 95% CI, 0.57-0.80; P < .01). CONCLUSIONS: This study demonstrates that the biomarkers have similar test characteristics which may make them interchangeable as indicators for the presence of @entity3 in @entity0 with @entity1 . @entity2 and BE correlate well with each other; however, AG was not as strongly correlated with either.

title: Comparing biomarkers of traumatic shock: the utility of anion gap, base excess, and serum XXXX in the ED.

answer: @entity2


abstract: INTRODUCTION: Over half a century ago the process of prevention of @entity5 in @entity0 with predisposed @entity3 was started. The application of prevention has been based on the fact that @entity5 is preceded by @entity4 , which can be caused by some invasive diagnostic and therapeutic procedures, and whose development can be prevented by applying antibiotics before an intervention. According to the latest guidelines of the European Society of Cardiology published this year, prevention is recommended only in high risk @entity0 with previous @entity5 , prosthetic valves, cyanotic @entity3 without surgical repair or with residual defects, palliative shunts or conduits, @entity3 with complete repair with prosthetic material up to six months after the procedure (surgery or percutaneous intervention), and when the residual defect persists at the site of implantation of a prosthetic material. In addition, antibiotic prophylaxis is limited to dental procedures with the manipulation of gingival or periapical region of the teeth or perforation of the oral mucosa. OBJECTIVE: The aim of this testing was to confirm whether these novelties in recommendations were applicable in our environment. METHODS: Fifty-seven @entity0 (44 @entity0 and 13 @entity0 ) with @entity5 were included in the testing. @entity5 was diagnosed in 68% of @entity0 based on two major criteria and in 32% based on one major and three minor criteria. RESULTS: In 54.4% of @entity0 the entry site of @entity1 could be determined. Twenty-one percent of @entity0 developed @entity1 after a dental intervention, 17.5% of @entity0 the @entity1 occurred after a skin/soft tissue lesion, whereas @entity2 preceded @entity5 in 14% of @entity0 and bowel @entity6 was a possible cause in of 1.75% of @entity0 . In all cases with @entity5 preceded by the dental intervention, antibiotic prophylaxis was not applied due to absent data of @entity3 or negligence. CONCLUSION: In our country a high incidence of @entity5 following dental procedures has been observed. One of possible reasons is poor oral hygiene. Its improvement and a regular dental control, as well as the individual risk assessment of intervention and conditions under which the intervention is performed could determine risk reduction for the development of @entity5 .

title: [Are new recommendations on the prevention of XXXX applicable in our environment?].

answer: @entity5


abstract: OBJECTIVE: To determine rates of adverse maternal and neonatal outcomes among nulliparous @entity0 undergoing elective labor induction compared with spontaneous labor. STUDY DESIGN: Retrospective chart review of term, nulliparous @entity0 with singleton gestations in 2007. Elective induction was defined as induction occurring from 37(0/7) to 41(0/7) weeks without ruptured membranes, fetal/maternal complications, or abnormal fetal testing. The primary outcome was cesarean delivery; secondary outcomes were @entity3 . Continuous variables were compared with t test and Mann-Whitney U, categorical with chi2 and Fisher's exact test. Logististic and linear regression were used to control for confounders and to assess independent effects of induction. RESULTS: Of850 nulliparous, singleton, term deliveries, 485 met criteria for inclusion. Cesarean delivery rate was 19.8% in the labor group and 33.6% in the induction group (p = 0.002). Odds ratio for cesarean was 2.1 (p = 0.001), 1.8 after adjustment for gestational age and birth weight, (p = 0.01). Length of stay (LOS) was significantly associated with induction even after adjustment for cesarean (beta = 0.7, p < 0.001). Rates ofepidural, postpartum @entity2 , pediatric delivery attendance and neonatal @entity1 requirement were higher with induction, before and after adjustment (p < 0.05). CONCLUSION: Elective induction of labor in nulliparas is associated with increased rates of cesarean, postpartum @entity2 , neonatal resuscitation and longer LOS without improvement in neonatal outcomes.

title: Maternal and neonatal morbidity among nulliparous XXXX undergoing elective induction of labor.

answer: @entity0


abstract: STUDY DESIGN: In a retrospective study, we report on 16 @entity0 with @entity4 due to progressively ossifying anterior unsegmented bars. OBJECTIVE: To specify the therapeutic strategy in such @entity2 . SUMMARY OF BACKGROUND DATA: @entity4 due to progressively ossifying anterior unsegmented bars is a particular and uncommon entity of @entity4 . @entity3 result in slowly progressive @entity4 , which rarely lead to neurological compromise. Sagittal equilibrium of the spine is maintained by compensatory curves adjacent to the primary curve. METHODS: All @entity0 had clinical assessment and successive measurements of segmental angle made on a standing lateral radiograph of the spine. Magnetic resonance imaging was obtained in four @entity0 . Six @entity0 were just observed. A brace was used in three. And seven were treated surgically. RESULTS: The compensatory capacity of the spine is reduced in lumbar area where there are few discs spaces below the bar. Presentation therefore tends to be at an earlier age and @entity1 is more common.Magnetic resonance imaging enables definition of the structures immediately posterior to the bar and provides information regarding the integrity of the intervertebral disc. CONCLUSION: There is usually no need for surgery in thoracic and thoracolumbar localization. In lumbar localization, if the diagnosis is done early in childhood and if magnetic resonance imaging shows beyond the anterior ossification a normal T2-weighted magnetic resonance imaging disc space signal, desepiphysiodesis bar resection and cement interposition is mandatory. If the disc magnetic resonance imaging signal is abnormal or if the disc space is totally ossified, we propose a surgical correction of the @entity4 . For such cases a posterior wedge osteotomy seems to be the more suitable procedure.

title: XXXX : a study of 16 cases.

answer: @entity3


abstract: BACKGROUND AND OBJECTIVE: Self-care by @entity1 ( @entity1 ) @entity0 is essential for optimal disease management of their condition. However, as the nature of @entity1 is unrelenting and burdensome, self-care is usually achieved with the support of partners. It is not clear what role the level of social support by partners plays in @entity1 self-care; therefore, this study sets out to determine the types of social support provided to @entity1 @entity0 and the impact of differing levels of social support on @entity1 @entity0 ' self-care. SUBJECTS AND METHOD: This is secondary analysis of a subgroup of @entity0 experiencing their second hospital admission for @entity1 at baseline in the COACH study, a multisite trial conducted in the Netherlands. Measures included the European @entity1 Self-care Behaviour Scale and a multiple component assessment of social support, which categorized @entity0 into low, moderate, and high levels of social support according to the presence of a partner and their perception of support they received from their partner. RESULTS AND CONCLUSIONS: @entity0 (n = 333) had an average age of 72 (SD, 11) years, and 92% belonged to New York Heart Association class III or greater. Of the @entity0 with partners (56%), only 49% had a high level of support from their partner. No demographic or clinical characteristic was associated with self-care behavior. @entity0 with a high level of support reported significantly better self-care (P = .002) than @entity0 with low or moderate levels of social support. @entity0 with a high level of social support reported being significantly more likely to consult with a health professional for @entity2 (P = .011), to limit the amount of fluids they have (P = .02), take their medication (P = .017), to get a flu shot (P = .001), and to exercise on a regular basis (P < .001) than those with medium or low levels of social support. The presence of social support by a partner is not sufficient to influence @entity1 @entity0 ' self-care. Social support provided by partners needs to be of a quality and content that matches @entity1 @entity0 ' perception of need to influence self-care. Caregivers, especially partners, should be considered as integral in the treatment and care of @entity1 @entity0 .

title: Social support and self-care in XXXX .

answer: @entity1


abstract: BACKGROUND: High-frequency deep brain stimulation (DBS) with a single electrical source is effective for motor symptom relief in @entity0 with @entity2 . We postulated that a multiple-source, constant-current device that permits well defined distribution of current would lead to motor improvement in @entity0 with @entity2 . METHODS: We did a prospective, multicentre, non-randomised, open-label intervention study of an implantable DBS device (the VANTAGE study) at six specialist DBS centres at universities in six European countries. @entity0 were judged eligible if they were aged 21-75 years, had been diagnosed with bilateral @entity2 with motor symptoms for more than 5 years, had a Hoehn and Yahr score of 2 or greater, and had a Unified @entity2 rating scale part III (UPDRS III) score in the medication-off state of more than 30, which improved by 33% or more after a @entity5 challenge. @entity0 underwent bilateral implantation in the subthalamic nucleus of a multiple-source, constant-current, eight-contact, rechargeable DBS system, and were assessed 12, 26, and 52 weeks after implantation. The primary endpoint was the mean change in UPDRS III scores (assessed by site investigators who were aware of the treatment assignment) from baseline (medication-off state) to 26 weeks after first lead implantation (stimulation-on, medication-off state). This study is registered with ClinicalTrials.gov, number NCT01221948. FINDINGS: Of 53 @entity0 enrolled in the study, 40 received a bilateral implant in the subthalamic nucleus and their data contributed to the primary endpoint analysis. Improvement was noted in the UPDRS III motor score 6 months after first lead implantation (mean 13  5 [SD 6  8], 95% CI 11  3-15  7) compared with baseline (37  4 [8  9], 34  5-40  2), with a mean difference of 23  8 (SD 10  6; 95% CI 20  3-27  3; p<0  0001). One @entity0 died of @entity1 24 weeks after implantation, which was judged to be unrelated to the procedure. 125 adverse events were reported, the most frequent of which were @entity6 , @entity7 , and apathy. 18 serious adverse events were recorded, three of which were attributed to the device or procedure (one case each of @entity3 , migration, and @entity4 ). All serious adverse events resolved without residual effects and stimulation remained on during the study. INTERPRETATION: The multiple-source, constant-current, eight-contact DBS system suppressed motor symptoms effectively in @entity0 with @entity2 , with an acceptable safety profile. Future trials are needed to investigate systematically the potential benefits of this system on postoperative outcome and its side-effects. FUNDING: Boston Scientific.

title: Multiple-source current steering in subthalamic nucleus deep brain stimulation for XXXX (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study.

answer: @entity2


abstract: INTRODUCTION: @entity4 ( @entity3 ) is a naturally occurring antimitotic agent and an interesting lead in the development of anticancer agents. Its optimization led to the development of @entity2 and @entity1 used in combination chemotherapy with other anticancer drugs; unlike @entity3 these drugs act by inhibiting topoisomerases. Clinical success and @entity0 issues at later stages of @entity2 usage inclined researchers to develop structurally modified @entity3 derivatives. Some of the compounds obtained are under clinical investigations and are anticipated to reach the market. AREAS COVERED: The present review summarizes the attempts made by researchers across the globe to find out newer anticancer agents based on the @entity3 structure. It brings out the outline of the inventions filed in the form of patents during the years 2012 - 2014. EXPERT OPINION: After the successful development of @entity2 and @entity1 there has been considerable interest in the @entity3 skeleton to develop newer chemotherapeutic agents. In this regard, several @entity3 derivatives such as TOP53, @entity5 , @entity6 , @entity7 , and so on, have been developed and are undergoing clinical trials. However, its low natural abundance is a major problem in carrying out research on @entity3 skeleton. This issue is expected to be addressed with the development of newer synthetic strategies to access structurally modified PPTs.

title: XXXX derivatives: a patent review (2012 - 2014).

answer: @entity4


abstract: BACKGROUND: @entity0 is the most common cause of deaths of @entity2 in @entity1 . Nowadays, following completion of imaging methods, mainly fine needle aspiration biopsy (FNAB) and core biopsy methods have been used for establishing cytopathological diagnosis although discussions regarding superiority continue. MATERIALS AND METHODS: Those with a complaint of "mass in breast" along with those diagnosed to have a mass as a result of routine physical examination among all @entity1 applying to our clinic between 01.01.2009 and 31.12.2011 were retrospectively assessed. Totals of 146 and 64 @entity1 with complete radiological observation who had undergone FNAB and core biopsies, respectively, were evaluated. Postoperative pathological results of @entity1 of both groups receiving surgery were also taken into consideration. All results were compared in terms of false positivity/negativity, sensitivity/specifity, surgery types and distribution of postoperative results with regard to diagnoses along with those of malignant/benign masses with regard to quadrants determined. RESULTS: @entity2 power of mammographic BIRADS classification was 87.3%. However, the value was 75% in the core biopsy group. Sensitivity and specifity following comparison of FNAB and postoperative pathology results of those receiving surgery were 85.4% and 92.9% while they were 93.5% and 100% in the core biopsy group. @entity2 power, calculated by determining AUC in ROC analysis, of FNAB was 89.1% while that of core biopsy was 96.7%. CONCLUSIONS: It was shown that core biopsy is superior to FNAB in terms of sensitivity, specificity and accurate histopathological classification. However; quick, cheap and basic diagnosis by means of FNAB should not be ignored. Sensitivity of FNAB is rather high in experienced hands and furthermore it would be expected to be lower than with core biopsy.

title: Comparison between Radiological and Invasive Diagnostic Modalities in Diagnosis of XXXX .

answer: @entity0


abstract: BACKGROUND: There have been few studies focusing on the curve pattern of @entity2 caused by @entity1 ( @entity1 ) in adolescents and the natural history of @entity2 after discectomy. The current study was carried out to identify the curve pattern of @entity2 and investigate the effect of posterior discectomy on the curve improvement in adolescents with @entity1 . METHODS: This review focused on a group of 26 adolescents with @entity1 who initially presented to our clinic for evaluation of @entity2 , followed by posterior discectomy between 2000 and 2009. Radiographic measurements included curve pattern, specific curve features, trunk shift, and sagittal profile. The correlation between the side of disc herniation and the direction of lumbosacral curve and the trunk shift was evaluated. RESULTS: A typical curve pattern was initially identified in all of the @entity0 as a short lumbosacral curve accompanied with a long thoracic or thoracolumbar curve toward the opposite side. 23 of 26 @entity0 (88.5%) had a trunk shift more than 2.0 cm away from the midline, showing a poor coronal balance. A relatively straight sagittal profile was noted in all the @entity0 . 84.6% (22/26) @entity0 had a disc herniation at the convex side of lumbosacral curve. Similarly, 73.1% (19/26) @entity0 showed a trunk shift toward the opposite side of disc herniation. All of the @entity0 had an marked curve improvement immediately after discectomy. In the 17 @entity0 with a more than 2-year follow-up, only two had a residual lumbosacral curve greater than or equal to 20 degrees. The mean ODI improved from 21.4% before surgery to 7.3% at the final follow-up. CONCLUSIONS: A short lumbosacral curve accompanied with a long thoracic or thoracolumbar curve toward the opposite side, and a relatively straight sagittal profile have been noted in all the @entity0 . The direction of lumbosacral curve and trunk shift was related to the side of disc herniation. A majority of @entity0 have a small curve size while assosiated with a significant coronal imbalance. Earlier decompression can provide a greater opportunity for spontaneous correction of @entity2 .

title: Scoliotic posture as the initial symptom in adolescents with XXXX : its curve pattern and natural history after lumbar discectomy.

answer: @entity1


abstract: BACKGROUND: @entity3 related to coronary artery bypass grafting (CABG) is poorly characterized, and understanding the characteristic release of biomarkers associated with revascularization injury might provide novel therapeutic opportunities. This study characterized early changes in biomarkers after revascularization injury during on-pump CABG. METHODS: This prospective study comprised 28 @entity0 undergoing on-pump CABG and late @entity8 enhancement (LGE) cardiac magnetic resonance imaging (CMRI) who underwent measurements of @entity11 ( @entity11 ), @entity6 kinase-MB, and inflammatory markers ( @entity7 , serum amyloid A, @entity10 , @entity5 , @entity1 @entity2 factor-a, @entity9 , plasminogen activator inhibitor-1a) at baseline, at 1, 6, 12, and 24 hours, and at 1 week (inflammatory markers only) post-CABG. Biomarker results at 1 hour were studied for a relationship to new @entity4 as defined by CMRI-LGE, and the diagnostic utility of combining positive biomarkers was assessed. RESULTS: All @entity0 had an uneventful recovery, but 9 showed a new @entity4 demonstrated by new areas of hyperenhancement on CMR. Peak @entity11 at 24 hours (   = 0.66, p < 0.001) and CK-MB (   = 0.66, p < 0.001) correlated with the amount of new LGE. At 1 hour, 3 biomarkers-- @entity11 , @entity5 , and @entity1 @entity2 factor-a--were significantly elevated in @entity0 with vs those without new LGE. Receiver operating curve analysis showed @entity11 was the most accurate at detecting new LGE at 1 hour: a cutoff of @entity11 exceeding 5  g/L at 1 hour had 67% sensitivity and 79% specificity for detecting new LGE. CONCLUSIONS: Unexpected CABG-related @entity3 occurs in a significant proportion of @entity0 . A @entity11 test at 1 hour after CABG could potentially differentiate @entity0 with significant revascularization injury.

title: Early diagnosis of perioperative XXXX after coronary bypass grafting: a study using biomarkers and cardiac magnetic resonance imaging.

answer: @entity4


abstract: OBJECTIVE: The aim of this study was to investigate changes in vocal symptoms in relation to @entity2 level in @entity0 undergoing in vitro fertilization. MATERIALS AND METHODS: A total of 31 @entity0 were enrolled in this study. The following vocal symptoms were investigated: vocal tiring or fatigue, vocal straining, throat clearing, lump sensation, hoarseness, and @entity4 (or loss of voice). The severity of these symptoms was graded from 0 to 4, where 0 means absence of the symptom and 3 means severe symptom presence. The frequency of these symptoms was evaluated in the first visit at presentation; second visit, 4 to 5 days after ovarian stimulation; and third visit, 8 to 10 days after stimulation. In the second and third visits, the @entity1 levels were measured. RESULTS: The mean age was 32.33    4.80 years. Ten of the 31 @entity0 had at least 1 vocal symptom. The most common vocal symptom in all 3 visits was throat clearing, with an incidence of 22.6% in the first and second visits and 19.4% in the third visit. This was followed by @entity3 , with an incidence of 9.68% for both. The incidence of all the vocal symptoms as well as their severity did not change throughout the visits, except for throat clearing, which has decreased in the third visit but not significantly (22.6% vs 19.4%, P = 1). Subjects with vocal symptoms had lower @entity1 level compared with those with no vocal symptoms; however, the difference was not statistically significant (P = .108 and .267, respectively). CONCLUSION: Subjects undergoing in vitro fertilization do not experience changes in their vocal symptoms when present, except for throat clearing. However, those with vocal symptoms have lower levels of @entity1 compared with those with no vocal symptoms.

title: Vocal symptoms in XXXX undergoing in vitro fertilization.

answer: @entity0


abstract: RATIONALE: The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic muscarinic @entity3 receptor subtype plays an important role in regulation of dopaminergic neurotransmission. OBJECTIVES: Here we investigated for the first time the involvement of @entity3 receptors in the reinforcing effects of cocaine using chronic intravenous cocaine self-administration in extensively backcrossed @entity3 (-/-)) @entity0 . METHODS: We evaluated acquisition of cocaine self-administration in experimentally na  ve @entity0 . Both cocaine self-administration and food-maintained operant behavior were evaluated under fixed ratio 1 (FR 1) and progressive ratio (PR) schedules of reinforcement. In addition, cocaine-induced dopamine release and cocaine-induced @entity2 were evaluated. RESULTS: @entity3 (-/-) @entity0 earned significantly more cocaine reinforcers and reached higher breaking points than their wild-type littermates ( @entity3 (+/+)) at intermediate doses of cocaine under both FR 1 and PR schedules of reinforcement. Under the PR schedule, @entity3 (-/-) @entity0 exhibited significantly higher response rates at the lowest liquid food concentration. In accordance with these results, cocaine-induced dopamine efflux in the nucleus accumbens and hyperlocomotion were increased in @entity3 (-/-) @entity0 compared to @entity3 (+/+) @entity0 . CONCLUSIONS: Our data suggest that @entity3 receptors play an important role in regulation of the reward circuitry and may serve as a new target in the medical treatment of @entity1 .

title: Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout XXXX .

answer: @entity0


abstract: BACKGROUND AND OBJECTIVES: Concomitant use of selective @entity4 reuptake inhibitors (SSRIs) and nonsteroidal anti-inflammatory drugs (NSAIDs) [including @entity2 ( @entity2 )] may potentiate the likelihood of @entity3 ( @entity3 ). The objectives of this study were to determine the prevalence and factors associated with concomitant SSRI/NSAID use among residents of long-term care facilities, and to investigate the use of gastroprotective drugs among concomitant SSRI/NSAID users. METHODS: The study sample comprised 1087 out of 1444 residents of all 53 long-term care wards in Helsinki, Finland, in September 2003. Data were extracted from residents' medication charts and medical records by trained nurses. Medication, diagnostic and mortality data were available for 1004 residents. RESULTS: Among the 1004 residents (mean        SD age 81.3        10.9 years), 28% used an SSRI, 38% used an NSAID and 24% used a gastroprotective drug. Thirteen percent of residents were concomitant users of SSRIs/NSAIDs. Concomitant use was associated with @entity0 (p   <   0.001), previous @entity1 (p   <   0.001) and a higher degree of co-morbidity (p   <   0.001). Gastroprotective drugs were used by 27% of concomitant users of SSRIs/NSAIDs compared with 37%, 20% and 22% of SSRI users, NSAID users and non-users of SSRIs/NSAIDs, respectively. One-year all-cause mortality was similar among all groups. CONCLUSION: The long-term facility residents in this study sample were frequently exposed to drug-drug interactions that potentiate the risk of @entity3 . Only about one-quarter of concomitant users of SSRIs/NSAIDs were prescribed a gastroprotective drug. Further initiatives are needed to optimize the use of SSRIs, NSAIDs and gastroprotective drugs.

title: Concomitant use of SSRIs, NSAIDs/ XXXX and gastroprotective drugs among residents of long-term care facilities: a medical record review.

answer: @entity2


abstract: BACKGROUND: The @entity5 ( @entity5 ) is part of the TGF-b superfamily and is abundantly expressed in the central nervous system. Changes in @entity5 homeostasis have been reported in @entity3 . AIM: To assess serum @entity5 concentration in elderly subjects with late-life @entity1 , before antidepressant treatment, as compared to healthy elderly controls. METHODS: Thirty-four elderly subjects with @entity1 and 37 age and gender-matched healthy elderly controls were included in this study. Diagnosis of @entity1 was ascertained by the @entity2 interview for DSM-IV and the severity of @entity1 symptoms was assessed by the Hamilton Depression Rating Scale ( @entity4 -21). Serum @entity5 concentration were determined by sandwich ELISA. RESULTS: @entity0 with @entity1 showed a significant reduction in @entity5 levels as compared to healthy elderly controls (p < 0.001). Also, @entity5 level was negatively correlated with @entity4 -21 scores (r = -0.343, p = 0.003). DISCUSSION: Our data provide evidence that @entity5 may be a state marker of @entity1 in older adults. Changes in the homeostatic control of @entity5 production may be a target to development of new antidepressant strategies.

title: Circulating Glial-derived neurotrophic factor is XXXX .

answer: @entity1


abstract: AIM: To explore the perceptions of loneliness according to @entity0 with early-stage @entity2 , living in community and long-term care and also the views of their family carers. BACKGROUND: Research that specifically explores the influence of loneliness on @entity2 is limited and indicates the prevalence of loneliness and the negative relationship between loneliness and @entity1 . There is a paucity of research that explores loneliness from the perspective of the @entity0 with @entity2 . DESIGN: A descriptive exploratory qualitative approach was used. METHODS: Data were collected through semi-structured audio-taped interviews. A purposive sample of 70 @entity0 with a diagnosis or probable @entity2 and 73 family carers were recruited from community and long-term care from South East Queensland, Australia. RESULTS: Four themes were identified: staying connected to others; losing the ability to socially engage; experiencing loneliness; and overcoming loneliness. The results emphasise the importance of familiar @entity0 relationships in reducing the feelings of loneliness in @entity0 experiencing @entity2 . CONCLUSIONS: @entity0 with @entity2 are at risk of loneliness, but placing them with unfamiliar @entity0 and environments may not improve their situation. RELEVANCE TO CLINICAL PRACTICE: Better refinement of care that takes into account the potential for loneliness and an understanding of premorbid social tendency may assist in the implementation of individualised and evidence-based strategies to assist @entity0 with @entity2 to lead a better quality of life. To maintain well-being, the social needs of the @entity0 with @entity2 as well as the family need to be considered.

title: XXXX and loneliness: an Australian perspective.

answer: @entity2