abstract: INTRODUCTION: Adherence to international guidelines is viewed as a prerequisite for optimal medical care delivery. Previously reported surveys for non-muscle-invasive @entity1 (NMIBC) employed mailed questionnaires to urologists or @entity0 resulting in conflicting degrees of agreement with existing guidelines. In the current study, contemporary information on the management of NMIBC was generated from a sample of italian centers. @entity0 AND METHODS: Eight Italian referral centers for the treatment of NMIBC were asked to collect information relative to all consecutive @entity0 with a histology-proven NMIBC undergoing a transurethral resection from January 1 to March 31, 2009. The primary study objective was to verify the level of adherence of disease management with European guidelines. RESULTS: 344 @entity0 resulted in being evaluable. 49.2% of high-risk @entity0 underwent a repeat transurethral resection. Bacillus Calmette-Gu  rin was employed in 35% of cases, while chemotherapy was in 22%. An early single regimen was adopted in 136 @entity0 and only in 1 out of 3 low-risk @entity0 . High-risk NMIBC received bacillus Calmette-Gu  rin and chemotherapy as first-line therapy in 66 and 12.5% respectively. After 3 months, cystoscopy had been reported for 82.5% of @entity0 with a recurrence rate of 13%. CONCLUSION: Adherence of Italian Institutions to EAU guidelines was optimal when reporting baseline variables. Significant degrees of discrepancy emerged in treatment choices.

title: Are referral centers for non-muscle-invasive XXXX compliant to EAU guidelines? A report from the vesical antiblastic therapy Italian study.

answer: @entity1


abstract: UNASSIGNED: @entity3 @entity0 after @entity4 have a poor prognosis. Approximately half never awakes as a result of severe @entity1 . Several neuroprotective agents have been tested, however without significant effect. In the present study, we used cultured neuronal networks as a model system to study the general synaptic damage caused by temporary severe @entity2 and the possibility to restrict it by ghrelin treatment. Briefly, we applied @entity2 ( @entity5 lowered from 150 to 20  mmHg) during 6  h in 55 cultures. Three hours after restoration of normoxia, half of the cultures were treated with ghrelin for 24  h, while the other, non-supplemented, were used as a control. All cultures were processed immunocytochemically for detection of the synaptic marker @entity6 . We observed that @entity2 led to drastic decline of the number of synapses, followed by some recovery after return to normoxia, but still below the prehypoxic level. Additionally, synaptic vulnerability was selective: large- and small-sized neurons were more susceptible to synaptic damage than the medium-sized ones. Ghrelin treatment significantly increased the synapse density, as compared with the non-treated controls or with the prehypoxic period. The effect was detected in all neuronal subtypes. In conclusion, exogenous ghrelin has a robust impact on the recovery of cortical synapses after @entity2 . It raises the possibility that ghrelin or its analogs may have a therapeutic potential for treatment of postanoxic @entity1 .

title: Acyl Ghrelin Improves Synapse Recovery in an In Vitro Model of XXXX .

answer: @entity1


abstract: Therapies to prevent severe @entity5 unconjugated @entity4 and kernicterus are phototherapy and, in unresponsive cases, exchange transfusion, which has significant morbidity and mortality risks. @entity3 is caused by the fraction of unconjugated @entity2 not bound to albumin (free @entity2 , Bf). Human serum albumin (HSA) administration was suggested to increase plasma @entity2 -binding capacity. However, its clinical use is infrequent due to difficulties to address its potential preventive and curative benefits, and to the absence of reliable markers to monitor @entity2 @entity3 risk. We used a genetic @entity1 model of unconjugated @entity4 showing severe @entity0 and @entity6 . We treated mutant pups with repeated HSA administration since birth, without phototherapy application. Daily intraperitoneal HSA administration completely rescued @entity0 and lethality, depending on dosage and administration frequency. Albumin infusion increased plasma @entity2 -binding capacity, mobilizing @entity2 from tissues to plasma. This resulted in reduced plasma Bf, forebrain and cerebellum @entity2 levels. We showed that, in our experimental model, Bf is the best marker to determine the risk of developing @entity0 . These results support the potential use of albumin administration in severe acute @entity4 conditions to prevent or treat @entity2 @entity3 in situations in which exchange transfusion may be required.

title: Albumin administration prevents XXXX and death in a @entity1 model of severe @entity5 @entity4 .

answer: @entity0


abstract: Therapies to prevent severe @entity5 unconjugated @entity4 and kernicterus are phototherapy and, in unresponsive cases, exchange transfusion, which has significant morbidity and mortality risks. @entity3 is caused by the fraction of unconjugated @entity2 not bound to albumin (free @entity2 , Bf). Human serum albumin (HSA) administration was suggested to increase plasma @entity2 -binding capacity. However, its clinical use is infrequent due to difficulties to address its potential preventive and curative benefits, and to the absence of reliable markers to monitor @entity2 @entity3 risk. We used a genetic @entity1 model of unconjugated @entity4 showing severe @entity0 and @entity6 . We treated mutant pups with repeated HSA administration since birth, without phototherapy application. Daily intraperitoneal HSA administration completely rescued @entity0 and lethality, depending on dosage and administration frequency. Albumin infusion increased plasma @entity2 -binding capacity, mobilizing @entity2 from tissues to plasma. This resulted in reduced plasma Bf, forebrain and cerebellum @entity2 levels. We showed that, in our experimental model, Bf is the best marker to determine the risk of developing @entity0 . These results support the potential use of albumin administration in severe acute @entity4 conditions to prevent or treat @entity2 @entity3 in situations in which exchange transfusion may be required.

title: Albumin administration prevents @entity0 and death in a @entity1 model of severe @entity5 XXXX .

answer: @entity4


abstract: Therapies to prevent severe @entity5 unconjugated @entity4 and kernicterus are phototherapy and, in unresponsive cases, exchange transfusion, which has significant morbidity and mortality risks. @entity3 is caused by the fraction of unconjugated @entity2 not bound to albumin (free @entity2 , Bf). Human serum albumin (HSA) administration was suggested to increase plasma @entity2 -binding capacity. However, its clinical use is infrequent due to difficulties to address its potential preventive and curative benefits, and to the absence of reliable markers to monitor @entity2 @entity3 risk. We used a genetic @entity1 model of unconjugated @entity4 showing severe @entity0 and @entity6 . We treated mutant pups with repeated HSA administration since birth, without phototherapy application. Daily intraperitoneal HSA administration completely rescued @entity0 and lethality, depending on dosage and administration frequency. Albumin infusion increased plasma @entity2 -binding capacity, mobilizing @entity2 from tissues to plasma. This resulted in reduced plasma Bf, forebrain and cerebellum @entity2 levels. We showed that, in our experimental model, Bf is the best marker to determine the risk of developing @entity0 . These results support the potential use of albumin administration in severe acute @entity4 conditions to prevent or treat @entity2 @entity3 in situations in which exchange transfusion may be required.

title: Albumin administration prevents @entity0 and death in a @entity1 model of severe XXXX @entity4 .

answer: @entity5


abstract: Therapies to prevent severe @entity5 unconjugated @entity4 and kernicterus are phototherapy and, in unresponsive cases, exchange transfusion, which has significant morbidity and mortality risks. @entity3 is caused by the fraction of unconjugated @entity2 not bound to albumin (free @entity2 , Bf). Human serum albumin (HSA) administration was suggested to increase plasma @entity2 -binding capacity. However, its clinical use is infrequent due to difficulties to address its potential preventive and curative benefits, and to the absence of reliable markers to monitor @entity2 @entity3 risk. We used a genetic @entity1 model of unconjugated @entity4 showing severe @entity0 and @entity6 . We treated mutant pups with repeated HSA administration since birth, without phototherapy application. Daily intraperitoneal HSA administration completely rescued @entity0 and lethality, depending on dosage and administration frequency. Albumin infusion increased plasma @entity2 -binding capacity, mobilizing @entity2 from tissues to plasma. This resulted in reduced plasma Bf, forebrain and cerebellum @entity2 levels. We showed that, in our experimental model, Bf is the best marker to determine the risk of developing @entity0 . These results support the potential use of albumin administration in severe acute @entity4 conditions to prevent or treat @entity2 @entity3 in situations in which exchange transfusion may be required.

title: Albumin administration prevents @entity0 and death in a XXXX model of severe @entity5 @entity4 .

answer: @entity1


abstract: BACKGROUND: Endovascular (EV) techniques are being advocated as the preferred method for mesenteric interventions because of their safety profile. However, midterm and long-term results are thought to be inferior to open interventions. We sought to compare our institutional experience with treatment of acute and chronic @entity2 (AMI and CMI, respectively) using EV and open techniques. METHODS: The medical records of open and EV mesenteric procedures performed at a single center were queried from 2002 to 2012. Demographic, perioperative, and follow-up data were extracted and analyzed. RESULTS: Thirty-eight @entity0 underwent EV mesenteric interventions, whereas 77 @entity0 underwent open revascularization. The demographic and perioperative characteristics for @entity0 were similar. Most EV procedures (89.2%) comprised stenting, whereas open procedures included 25 (32.1%) antegrade bypasses, 38 (48.7%) retrograde bypasses, 8 (10.3%) thromboembolectomies, and 7 (9%) transaortic endarterectomies. @entity1 , overall 30-day morbidity and mortality were not significantly different in the open and EV groups for AMI or CMI. Thirty-day mortality in AMI (n  =  34) was 38.2% (EV: 45.5% vs. open: 34.8%; P  =  nonsignificant). There was no mortality in either group for CMI @entity0 . Mean follow-up was much longer for the open procedures (34.9 vs. 12.7  months, P  =  0.004). Primary and secondary patency rates were better for open revascularization for CMI @entity0 . CONCLUSIONS: Open revascularizations are equally safe as EV interventions for AMI and CMI. Patency of open revascularization for CMI is better than EV procedures at midterm follow-up.

title: Open Mesenteric Interventions Are Equally Safe as Endovascular Interventions and Offer Better Midterm Patency for XXXX .

answer: @entity2


abstract: OBJECTIVES: To refine models to predict surgical morbidity and 90-day mortality after @entity2 ( @entity2 ) for @entity1 (EOC). METHODS: @entity0 with stage IIIC/IV EOC who underwent @entity2 with curative intent between 1/2/2003 and 12/30/2011 were included. @entity0 characteristics, intraoperative and postoperative outcomes, and vital status were abstracted. Complications were graded using the Accordion classification. Nomograms were generated based on multivariate modeling. RESULTS: 138 (22.3%) of the 620 @entity0 who underwent @entity2 experienced a grade>= 3 complication. Age (OR 1.21 per 10years increase in age), BMI (OR 1.35 for BMI<25kg/m(2) versus reference, OR 2.83 for BMI>= 40kg/m(2) versus reference), ASA score>= 3 (OR 1.49), stage (OR 1.69 stage IV) and surgical complexity (OR 2.32 high complexity versus intermediate) were predictive of an accordion grade>= 3 complication Within 90days of surgery, 55 (8.9%) @entity0 died. A multivariable model included age (OR 1.76 per 10year increase in age), ASA score>= 3 (OR 3.28), preoperative albumin<3.5 (OR 4.31), and BMI (OR 2.04 for BMI<25kg/m(2) versus reference, OR 3.64 for BMI>= 40kg/m(2) versus reference) was predictive of 90-day mortality. CONCLUSION: Using an independent cohort we report the importance of age, ASA score, preoperative albumin, FIGO stage, and surgical complexity, and BMI, to refine a prediction model for complications after @entity2 for advanced EOC. This information is useful in preoperative counseling and can be utilized to aid in @entity0 -centered decision making and risk stratification.

title: Risk-prediction model of severe postoperative complications after @entity2 for advanced XXXX .

answer: @entity1


abstract: OBJECTIVES: To refine models to predict surgical morbidity and 90-day mortality after @entity2 ( @entity2 ) for @entity1 (EOC). METHODS: @entity0 with stage IIIC/IV EOC who underwent @entity2 with curative intent between 1/2/2003 and 12/30/2011 were included. @entity0 characteristics, intraoperative and postoperative outcomes, and vital status were abstracted. Complications were graded using the Accordion classification. Nomograms were generated based on multivariate modeling. RESULTS: 138 (22.3%) of the 620 @entity0 who underwent @entity2 experienced a grade>= 3 complication. Age (OR 1.21 per 10years increase in age), BMI (OR 1.35 for BMI<25kg/m(2) versus reference, OR 2.83 for BMI>= 40kg/m(2) versus reference), ASA score>= 3 (OR 1.49), stage (OR 1.69 stage IV) and surgical complexity (OR 2.32 high complexity versus intermediate) were predictive of an accordion grade>= 3 complication Within 90days of surgery, 55 (8.9%) @entity0 died. A multivariable model included age (OR 1.76 per 10year increase in age), ASA score>= 3 (OR 3.28), preoperative albumin<3.5 (OR 4.31), and BMI (OR 2.04 for BMI<25kg/m(2) versus reference, OR 3.64 for BMI>= 40kg/m(2) versus reference) was predictive of 90-day mortality. CONCLUSION: Using an independent cohort we report the importance of age, ASA score, preoperative albumin, FIGO stage, and surgical complexity, and BMI, to refine a prediction model for complications after @entity2 for advanced EOC. This information is useful in preoperative counseling and can be utilized to aid in @entity0 -centered decision making and risk stratification.

title: Risk-prediction model of severe postoperative complications after XXXX for advanced @entity1 .

answer: @entity2


abstract: Recombinant @entity0 @entity1 ) produced in @entity2 was labeled with 125I to study its binding to receptors of HeLa and lymphoblastoid cells. All the cell lines examined had receptors for @entity6 , although the binding varied considerably among different cell lines. The binding of 125I- @entity6 was competed up to 90% by the addition of unlabeled @entity6 , although not by the addition of @entity5 or -beta. By adding increasing concentrations of unlabeled @entity6 to binding assays containing a constant amount of 125I- @entity6 , we determined a KD of 3.7 and 6.3 X 10(-10) M for its binding to Daudi and HeLa cells, respectively. About 13,000 receptors per cell were present in Daudi and 5,000 in HeLa cells. The Mr of the @entity1 /receptor complex was determined by cross-linking experiments to be about 125,000. This complex is smaller than the @entity5 /receptor complex that has a Mr of about 140,000. The @entity6 receptor was down-regulated when HeLa cells were treated with this interferon, but not when these cells were treated with @entity4 . These findings suggest that the receptors for @entity5 and -gamma differ in several characteristics. The turnover of the @entity6 receptor was measured by inhibiting protein synthesis with @entity3 and the half-life of this receptor was found to be 2 h. The unglycosylated @entity6 was bound to cellular receptors with an affinity similar to that previously reported for natural @entity1 . The lymphoblastoid cell lines examined had high affinity receptors for @entity6 , but did not respond to treatment with this IFN with an induction of the synthesis of the enzyme (2'-5')oligo(A) synthetase, whereas HeLa cells responded to @entity6 . The reason for the lack of response of lymphoblastoid cells is presently unknown.

title: Binding of XXXX recombinant 125I-interferon gamma to receptors on @entity0 cells.

answer: @entity0


abstract: Recombinant @entity0 @entity1 ) produced in @entity2 was labeled with 125I to study its binding to receptors of HeLa and lymphoblastoid cells. All the cell lines examined had receptors for @entity6 , although the binding varied considerably among different cell lines. The binding of 125I- @entity6 was competed up to 90% by the addition of unlabeled @entity6 , although not by the addition of @entity5 or -beta. By adding increasing concentrations of unlabeled @entity6 to binding assays containing a constant amount of 125I- @entity6 , we determined a KD of 3.7 and 6.3 X 10(-10) M for its binding to Daudi and HeLa cells, respectively. About 13,000 receptors per cell were present in Daudi and 5,000 in HeLa cells. The Mr of the @entity1 /receptor complex was determined by cross-linking experiments to be about 125,000. This complex is smaller than the @entity5 /receptor complex that has a Mr of about 140,000. The @entity6 receptor was down-regulated when HeLa cells were treated with this interferon, but not when these cells were treated with @entity4 . These findings suggest that the receptors for @entity5 and -gamma differ in several characteristics. The turnover of the @entity6 receptor was measured by inhibiting protein synthesis with @entity3 and the half-life of this receptor was found to be 2 h. The unglycosylated @entity6 was bound to cellular receptors with an affinity similar to that previously reported for natural @entity1 . The lymphoblastoid cell lines examined had high affinity receptors for @entity6 , but did not respond to treatment with this IFN with an induction of the synthesis of the enzyme (2'-5')oligo(A) synthetase, whereas HeLa cells responded to @entity6 . The reason for the lack of response of lymphoblastoid cells is presently unknown.

title: Binding of @entity0 recombinant 125I-interferon gamma to receptors on XXXX cells.

answer: @entity0


abstract: OBJECTIVE: The aim of the study was to evaluate @entity0 treated for impacted mandibular @entity1 through a combined surgical and orthodontic approach. STUDY DESIGN: The cases which were made button operations of impacted mandibular @entity1 were selected from 5100 panoramic radiographs taken from @entity0 who made use of our oral and maxillofacial surgery services between January 1998 to April 2006. All of these selected @entity0 were assessed radiographically. Pertinent information such as sex, age at the time of surgery, site of the unerupted tooth, space availability and any other associated pathoses were also recorded. These @entity0 were called again, and the condition of the mandibular @entity1 was evaluated with panoramic radiographs. If the tooth erupted in the right position and it was functional and asymptomatic, we assumed the treatment to be successful clinically. RESULTS: In the present study, from 5100 @entity0 , 69 @entity0 had impacted mandibular @entity1 and only 21 @entity0 ' teeth (a total of 23 teeth) were treated orthodontically. Sixteen impacted mandibular @entity1 teeth of 14 @entity0 erupted successfully. Two impacted @entity1 were extracted, and only one @entity1 tooth was transplanted to the normal position. Four @entity0 ended the treatment because of failure of eruption. CONCLUSION: If a mandibular @entity1 tooth is impacted, not only is surgical exposure sufficient but also traction force must be applied orthodontically after the surgical exposure. In addition, age influences the success of the treatment on impacted mandibular @entity1 teeth more than the position and impaction level of the teeth.

title: Evaluation of surgical-orthodontic treatments on impacted mandibular XXXX .

answer: @entity1


abstract: OBJECTIVE: To evaluate the predicting factors for the development of @entity3 , its frequency and influencing factors after elective endovascular repair (EVAR) of @entity2 ( @entity2 ). METHODS: Data were prospectively collected in a unicenter observational study (tertiary center of [endo-] vascular surgery) and retrospectively evaluated in @entity0 who had undergone elective EVAR of @entity2 . Vascular (lumbar arteries (LA) and inferior mesenteric artery, @entity1 ) and general @entity0 (habits, medication, basic diseases) as well as procedural characteristics, were analyzed for their association with the development of @entity3 . Pre and postinterventional computed tomography (CT) scans were evaluated for @entity1 anatomy, in particular, postinterventional growth or shrinkage as well detection of an endoleak of each type. RESULTS: The study cohort included 82 @entity0 (mean age, 72 (52-87) years; 77 @entity0 , 93.9   %) throughout 36 months. The median follow-up period was 29.5 months (range, 1-57). Overall, 51 @entity3 (62.2   %) were identified at any time during the postinterventional follow-up period. In the Cox regression, @entity2 length was the only significant predictor (P   =   0.024; hazard ratio (HR), 1.07; 95   % confidence interval (CI), 1.01-1.14). Thirteen @entity0 (15.8   %) underwent at least one secondary intervention. @entity1 growth was observed in four @entity0 because of an @entity3 (4.9   %). No @entity4 occurred in association with an isolated @entity3 . CONCLUSION: The preoperative @entity2 length (correlating with the number of LA) can be considered a risk factor for postinterventional occurrence of @entity3 prompting to greater attention and possible preemptive therapy.

title: Length of XXXX and incidence of @entity3 after endovascular repair.

answer: @entity2


abstract: OBJECTIVE: To evaluate the predicting factors for the development of @entity3 , its frequency and influencing factors after elective endovascular repair (EVAR) of @entity2 ( @entity2 ). METHODS: Data were prospectively collected in a unicenter observational study (tertiary center of [endo-] vascular surgery) and retrospectively evaluated in @entity0 who had undergone elective EVAR of @entity2 . Vascular (lumbar arteries (LA) and inferior mesenteric artery, @entity1 ) and general @entity0 (habits, medication, basic diseases) as well as procedural characteristics, were analyzed for their association with the development of @entity3 . Pre and postinterventional computed tomography (CT) scans were evaluated for @entity1 anatomy, in particular, postinterventional growth or shrinkage as well detection of an endoleak of each type. RESULTS: The study cohort included 82 @entity0 (mean age, 72 (52-87) years; 77 @entity0 , 93.9   %) throughout 36 months. The median follow-up period was 29.5 months (range, 1-57). Overall, 51 @entity3 (62.2   %) were identified at any time during the postinterventional follow-up period. In the Cox regression, @entity2 length was the only significant predictor (P   =   0.024; hazard ratio (HR), 1.07; 95   % confidence interval (CI), 1.01-1.14). Thirteen @entity0 (15.8   %) underwent at least one secondary intervention. @entity1 growth was observed in four @entity0 because of an @entity3 (4.9   %). No @entity4 occurred in association with an isolated @entity3 . CONCLUSION: The preoperative @entity2 length (correlating with the number of LA) can be considered a risk factor for postinterventional occurrence of @entity3 prompting to greater attention and possible preemptive therapy.

title: Length of @entity2 and incidence of XXXX after endovascular repair.

answer: @entity3


abstract: OBJECTIVES: To explore the correlation between the severity of radiotherapy-induced @entity4 (RTG) and endothelial cell injury in local tissues in a @entity0 model. STUDY DESIGN: The RTG animal model was designed and used by our team. The @entity2 index(OMI) was documented daily. Immunohistochemistry (IHC) Staining of @entity3 was utilized to identify endothelial cells in the RTG tissues. Apoptosis of endothelial cells in local lesions due to RTG was detected by the TUNEL assay. The dynamic relationship between the OMI and apoptotic endothelial cells was statistically analyzed by time. RESULTS AND CONCLUSIONS: The injury and apoptosis of endothelial cells were observed 3 day post-irradiation. The vascular lumens of the post-irradiation tongue lesions were irregular; @entity1 formation in the center of the lumens, unsmooth lumen walls and vasodilated vessels were observed. Also, endothelial cells detached from the basal membrane and were found in the lumens. The percentages (%) of apoptotic endothelial cells were 78.3    0.31 (5 day); 89.3    0.83 (8 day); 83.5    0.41 (14 day); 69.3    0.57 (21 day); and 47.3    0.59 (28 day). The OMI was correlated with the percentage of apoptotic endothelial cells (R=0.67, P=0.034). Summary, endothelial cell injury was correlated with the pathogenic condition of RTG.

title: The correlation between the severity of radiotherapy-induced XXXX and endothelial cell injury in local tissues in a @entity0 model.

answer: @entity4


abstract: OBJECTIVES: To explore the correlation between the severity of radiotherapy-induced @entity4 (RTG) and endothelial cell injury in local tissues in a @entity0 model. STUDY DESIGN: The RTG animal model was designed and used by our team. The @entity2 index(OMI) was documented daily. Immunohistochemistry (IHC) Staining of @entity3 was utilized to identify endothelial cells in the RTG tissues. Apoptosis of endothelial cells in local lesions due to RTG was detected by the TUNEL assay. The dynamic relationship between the OMI and apoptotic endothelial cells was statistically analyzed by time. RESULTS AND CONCLUSIONS: The injury and apoptosis of endothelial cells were observed 3 day post-irradiation. The vascular lumens of the post-irradiation tongue lesions were irregular; @entity1 formation in the center of the lumens, unsmooth lumen walls and vasodilated vessels were observed. Also, endothelial cells detached from the basal membrane and were found in the lumens. The percentages (%) of apoptotic endothelial cells were 78.3    0.31 (5 day); 89.3    0.83 (8 day); 83.5    0.41 (14 day); 69.3    0.57 (21 day); and 47.3    0.59 (28 day). The OMI was correlated with the percentage of apoptotic endothelial cells (R=0.67, P=0.034). Summary, endothelial cell injury was correlated with the pathogenic condition of RTG.

title: The correlation between the severity of radiotherapy-induced @entity4 and endothelial cell injury in local tissues in a XXXX model.

answer: @entity0


abstract: BACKGROUND: The prevalence of @entity2 ( @entity2 ) and its consequences on @entity0 's reproductive health and pregnancy outcomes have been well documented. Bangladesh is burdened with the high prevalence of @entity2 and induced abortion/menstrual regulation. Understanding their association may benefit strategies to reduce termination of pregnancy (TOP). Therefore, this study assesses the association between experience of @entity2 and TOP among married Bangladeshi @entity0 age 15-49 years. METHODS: This cross-sectional study is based on data from 10,146 married @entity0 of reproductive age from the Bangladesh Demographic Health Survey, 2007 (BDHS). A subset of interviews from currently married @entity0 , living with a husband and who had at least one pregnancy in the last 5  years (n   =   1875) were extracted. RESULTS: Results of this study showed that among the respondents, 31.4  % experienced physical and/or sexual @entity2 : 13.4  % experienced only @entity1 and 25.8  % experienced only physical violence. 21.0  % respondents ever had a TOP and 5.8  % had a TOP in last 5  years. Physical @entity2 was significantly associated with both TOP ever (OR   =   1.36; 95  % CI: 1.05-1.77) and TOP in last 5  years (OR   =   1.72; 95  % CI: 1.11-2.06). CONCLUSIONS: Prevention of @entity2 which was associated with pregnancy termination may reduce the high incidence of termination of pregnancies in Bangladesh.

title: Intimate partner violence and termination of pregnancy: a cross-sectional study of married Bangladeshi XXXX .

answer: @entity0


abstract: BACKGROUND: We retrospectively compared the oncologic outcome after segmentectomy versus lobectomy in @entity0 with clinical (c-) T1a N0 M0 @entity1 ( @entity1 ) detected as a part-solid ground-glass nodule or purely solid nodule on thin-section computed tomography. METHODS: From 1997 to 2010, 312 @entity0 with c-T1a N0 M0 @entity1 were determined to require a surgical approach categorized as segmentectomy or lobectomy. Preoperatively available data were collected using logistic regression analysis, and propensity matching was performed. Factors affecting local-regional recurrence were assessed by Cox proportional hazards regression analysis and Kaplan-Meier estimates. RESULTS: The 5-year and 10-year overall survival rates for the 80 @entity0 who underwent segmentectomy were 97.5% and 83.5%, respectively, compared with 87.75% and 75.0%, respectively, for the 232 @entity0 who underwent lobectomy (p  = 0.019). Local-regional recurrence as the first relapse site was found in 3 the 80 segmentectomies (3.8%) of and in 15 of the 232 lobectomies (6.5%). The difference in local-regional recurrence-free survival in @entity0 undergoing segmentectomy compared with lobectomy was not significant (p  = 0.304). In 69 propensity score-matched pairs, there was no significant difference in the overall survival (p  = 0.442) or local-regional recurrence-free survival (p  = 0.717) between the two groups. Multivariate analysis using the Cox proportional hazards regression model identified lymphatic invasion as the only independent factor predicting local-regional recurrence (relative risk, 10.764; 95% confidence interval, 2.98 to 57.68). CONCLUSIONS: Our results suggest that the oncologic outcome of segmentectomy vs lobectomy is similar in this  cohort of c-T1a N0 M0 @entity1 @entity0 . These results will be validated by large-scale, prospective, randomized trials.

title: Oncologic Outcomes of Segmentectomy Versus Lobectomy for Clinical T1a N0 M0 XXXX .

answer: @entity1


abstract: BACKGROUND: @entity0 with @entity4 ( @entity4 ) are under risk of @entity2 . It readily necessitates very complicated surgery and massive blood transfusion, and even leads to mortality. Cesarean hysterectomy (CH) is the procedure that is acknowledged worldwide, since it helps to minimize complications. CASE PRESENTATION: A @entity0 with dichorionic twin pregnancy underwent to cesarean section (CS) due to preliminary diagnosis of @entity5 at her 35(th) week of pregnancy. Both of the placentas were left in situ. The @entity0 admitted with signs of @entity1 . @entity3 was performed 7  weeks after CS. In the course of hysterectomy, 3 units of erythrocyte suspension and 2 units of fresh frozen plasma were transferred, whereas none was required during CS. CONCLUSION: Abandoning placenta in situ seems to be a logical alternative to the CH in @entity0 with @entity5 in order to minimize complications related to massive blood transfusion and surgical technique. However, it appears to increase maternal morbidity due to maternal @entity1 in twin pregnancy.

title: What should we do to optimise outcome in twin pregnancy complicated with XXXX ? A case report.

answer: @entity5


abstract: BACKGROUND: Severe @entity9 results in more than 10% incidence of @entity2 and transient @entity1 attack. Using undersized angioplasty with off-label closed-cell Enterprise stent may be a feasible alternative option for treating @entity0 with @entity8 who fail dual-antiplatelet medical therapy. The results of the authors' study are presented in this paper. MATERIALS AND METHODS: Between January 2013 and July 2014, 24 symptomatic @entity0 with a total of 30 intracranial arterial stenotic lesions refractory to medical therapy, who underwent undersized angioplasty and Enterprise stenting, were retrospectively reviewed in the authors' institution. The results evaluated include technical success rate, clinical outcome measured as modified Rankin Scale at presentation and follow-up, peri-procedural morbidity within 30 days and 1 year, and follow-up vessel patency. RESULTS: Stent deployment was successfully achieved in all stenotic lesions (30/30). Mean pre-stent and post-stent diameter residual stenosis was 81% and 18%, respectively. The peri-procedural complication rate during 30 days after stenting was 10% per lesion (3/30), including @entity6 , in-stent @entity5 and @entity4 . No further @entity7 event or complication occurred in any @entity0 more than 30 days after stenting. Modified Rankin scale    <=   2 was observed in 64% and 83% of @entity0 at initial presentation and follow-up (mean 15.8 months), respectively. Imaging follow-up was available in 17 of 24 @entity0 (70.8%) and 20 of 30 treated lesions (66.6%) with a mean follow-up period of 15.4 months. Only one asymptomatic in-stent @entity3 occurred in 20 available lesions (5.0%). CONCLUSION: This preliminary study suggests that using undersized angioplasty and Enterprise stenting may effectively treat high-degree symptomatic @entity9 with favorable clinical and angiographic outcome.

title: Undersized angioplasty and stenting of symptomatic XXXX with Enterprise: Evaluation of clinical and vascular outcome.

answer: @entity6


abstract: Sequential hypertonic dialysis (SHD) was studied in two binephrectomized @entity0 over a period of 6 weeks. Each dialysis session comprised four periods of 45 min. The concentration of @entity3 in the dialysate [ @entity5 ] during the first period was 190 mmol/l and during the second period 140 mmol/l. The sequence was then repeated. The @entity3 -free water clearance [C(ONa)] was calculated from the measurements of the ultrafiltrate clearance and of the @entity3 clearance. Despite the short periods of hypertonic dialysis, C(ONa) was positive, suggesting that water was removed from the intracellular compartment as well as from the extracellular fluid. The transfer of fluid from the intracellular space improved circulatory stability during rapid removal of large volumes of fluid by ultrafiltration. SHD was also associated with increased removal of @entity2 and @entity4 . Comparison of clinical parameters before and during SHD showed a tendency towards increased @entity3 balance and the possibility of raised @entity1 . SHD stabilized blood volume during ultrafiltration, encouraging @entity6 . SHD with this level of @entity5 is only a study dialysis method.

title: Sequential hypertonic haemodialysis in XXXX .

answer: @entity0


abstract: BACKGROUND: Peri-stent coronary evaginations may disturb flow and have been proposed as possible risk factor for late stent @entity4 . We describe incidence, predictors, and possible mechanisms of coronary evaginations 12 months after implantation of bioresorbable vascular scaffolds (BVS). METHODS AND RESULTS: One hundred and two BVS implanted in 90 @entity0 (age 63    13 years, 71 males, 14 @entity1 ) were analysed with angiography and optical coherence tomography (OCT) 12 months after implantation. Evaginations were identified as any hollow in the luminal vessel contour between well-apposed struts and were classified as major when extending >= 3 mm with a depth >= 10% of the BVS diameter. Fifty-five (54%) of the BVS (50(56%) of the @entity0 ) had at least one evagination (6.1    6.2 evaginations per BVS), with a mean volume of 1.9    1.9 mm(3). Major evaginations were only found in one @entity0 , and in-BVS @entity3 in three @entity0 (4BVS). The presence of evaginations was strongly associated with that of malapposition (P = 0.003) and strut @entity2 (P = 0.01). No association could be shown between the presence and volume of the evaginations and any clinical variable or the presence of uncovered struts (P > 0.5). Peri-strut low-intensity areas (PSLIA) were present in 29 (53%) of the BVS with evaginations and 12 (26%) of those without (P = 0.0049); their presence was independently associated with the presence, the number (P < 0.003) and volume of the evaginations (P = 0.004) and with that of strut @entity2 . CONCLUSIONS: Optical coherence tomography-detected evaginations are relatively common after BVS implantation, but, as for modern drug-eluting metallic stents, major evaginations are very rare. Optical coherence tomography evidence of immature neointima and strut @entity2 were associated with more severe development of evaginations.

title: Coronary evaginations and peri-scaffold XXXX following implantation of bioresorbable scaffolds: incidence, outcome, and optical coherence tomography analysis of possible mechanisms.

answer: @entity3


abstract: OBJECTIVES: The purpose of this study was to compare the clinical effectiveness in reducing large overjet between a prefabricated functional appliance (PFA) and a slightly modified @entity3 ( @entity3 ). SETTING AND SAMPLE POPULATION: Public Dental Service, Gothenburg, Sweden. @entity0 , STUDY DESIGN, AND METHODS: A multicentre, prospective randomized clinical trial was conducted with @entity0 from 12 general dental practices. One hundred and five @entity0 with an Angle Class II, division 1 @entity2 and an overjet of >= 6mm were eligible for the study. Eight @entity0 were excluded due to various reasons and the sample consisted thus of 97 subjects (44 @entity0 , 53 @entity0 ) with a mean age of 10.3 years. The study was designed as intention to treat and the @entity0 were randomly allocated by lottery to treatment with either a PFA or an @entity3 . The PFA and @entity3 group consisted of 57 subjects (28 @entity0 , 29 @entity0 ) and 40 subjects (16 @entity0 , 24 @entity0 ), respectively. Overjet, @entity1 , lip seal, and sagittal molar relationship were recorded before, at the end of treatment and 1-year post-treatment. Blinding was not performed. The endpoint of treatment was set to overjet  <=3mm and after this a 6 months retention period followed. RESULTS: No significant difference was found in overjet, @entity1 , sagittal relation, and lip seal between the two groups for the total observation period. The treatment of 40 (70 per cent) @entity0 with PFA and 21 (53 per cent) with @entity3 were considered unsuccessful mainly due to poor compliance. LIMITATIONS: No cephalometric records were taken as only @entity0 -centred clinical outcome were used as an indicator for treatment success. The criteria of reduction of overjet to as low as 3mm could have affected the success rate. CONCLUSION: No difference in effectiveness could be shown between PFAs and AAs in correcting overjet, @entity1 , sagittal molar relation, and lip seal. The success rate in treatment with both appliances is, however, low. REGISTRATION: This trial was registered in "FoU i Sverige" (http://www.fou.nu/is/sverige), registration number: 97131. PROTOCOL: The protocol was not published before trial commencement.

title: Treatment of large overjet in Angle Class II: division 1 XXXX with Andresen activators versus prefabricated functional appliances-a multicenter, randomized, controlled trial.

answer: @entity2


abstract: Five cases of @entity3 are reported with special emphasis on the initial CT findings of these cases. One case was already reported by Endo (1974). The cases are three in @entity0 and two in adults, male four cases and female one case. Four cases had @entity9 , one open. Consciousness level on admission were diversely from clear to semicomatose. Three cases experienced @entity2 of @entity4 . Time of diagnosis from @entity1 was from two days to 34 days. Location of @entity4 were near the junction of callosomarginal artery three cases, frontopolar artery one case, and A1-A2 junction one case. Operation was performed in four cases. Results were good in three cases and fair in a case. A case of no operation had fracture of anterior skull base and died from massive @entity7 . Autopsy showed an @entity4 of A1-A2 junction, extending to sphenoid sinus. Histological findings of aneurysmal walls were @entity8 in all cases. There were 48 cases of @entity3 in the literature. Most of cases are near the junction of callosomarginal artery. As the etiology of the @entity4 it is said that falx cerebri damages the arterial wall. We consider tear of junction of callosomarginal artery is a important factor, since the brain can easily move at the anterior portion of falx. It is very difficult to diagnosis traumatic @entity4 before @entity2 . But in our three cases of @entity3 , computed tomographies of very early stage of @entity1 showed interhemispherical high density area, @entity6 and @entity5 of corpus callosum.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Traumatic anterior cerebral XXXX --experiences in 4 cases and review of the literature].

answer: @entity3


abstract: Fifty three consecutive @entity0 with @entity3 underwent two-dimensional echocardiography 1-3 days after admission. In order to (1) determine if this procedure can detect regional ventricular asynergy in an unselected series of @entity0 . (2) to determine whether the procedure can identify @entity0 at high risk for @entity5 , before the onset of hemodynamic deterioration and (3) to identify the inmmediate complications of @entity3 . For purposes of analysis of the present protocol, the ventricles were divided in a system of walls, segments and levels resulting in 22 potential regions. Technically satisfactory two-dimensional echocardiographic studies were obtained in 48 @entity0 (90.56%). Of 1056 possible segments in the 48 @entity0 all were deemed adequate for analysis. Akinesis was detected in 2 segments (0.18%), dyskinesis in 45 segments (4.26%), hypokinesis in 170 (16.09%), @entity6 15 (1.42%) and normal 824 (78.03%). The more segments damaged were observed by two dimensional echo, the more clinical and hemodinamically compromised status of the @entity0 was assessed. The immediate complications were as follows: Pericardial effusion 20 cases (45.45%), @entity1 14 (31.81%), mural @entity4 (13.63%) @entity2 3 (16.81%) ruptured septum in 1 (2.27%). Thus two-dimensional echocardiography performed soon after admission to the coronary care unit is technically feasible, provides useful information concerning regional and global left ventricular function and offers important predictive information about @entity0 early in @entity3 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Evaluation and identification of the extension of acute XXXX and its complications by bidimensional echocardiography].

answer: @entity3


abstract: Functional recovery with surgical revascularization of acutely ischemic myocardium has not been compared with its nonsurgical counterpart in experimental preparations of @entity4 . This study compares the functional and metabolic recovery of ischemic (1 hr @entity4 ) segments revascularized either by restoration of coronary patency (simulating nonsurgical recanalization, e.g., angioplasty) or by surgical revascularization with multidose hypothermic @entity3 blood cardioplegic solution. Twenty-two anesthetized open-chest @entity0 were instrumented with Millar micromanometer-tip catheters to measure left ventricular and aortic pressures. Piezoelectric ultrasonic dimension gauges were implanted in the subendocardium supplied by the left anterior descending coronary artery to measure segmental contractile function. In five @entity0 , only biopsy samples were obtained for control measurements of @entity2 , @entity5 , and tissue water content. In the remaining 17 @entity0 , the left anterior descending artery and collaterals were ligated for 1 hr. The ligatures were removed in eight @entity0 and coronary perfusion continued for 2 hr, simulating nonsurgical reperfusion. The remaining nine @entity0 were placed on cardiopulmonary bypass and the hearts were arrested for 1 hr with multidose (every 20 min) blood cardioplegic solution enhanced with @entity6 and @entity1 , simulating surgical revascularization (coronary artery bypass grafting). The coronary ligatures were not released until the second cardioplegic infusion, simulating graft placement. One hour of @entity4 placed 39.4 +/- 2.5% of the left ventricle at risk, and converted active systolic shortening to persistent paradoxical bulging (25.2 +/- 2.2% to -5.8 +/- 1.2% systolic shortening).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Immediate functional recovery and avoidance of reperfusion injury with surgical revascularization of short-term XXXX .

answer: @entity4


abstract: From June 1976 to December 1984, 48 previously untreated @entity0 with @entity3 ( @entity3 ) were treated according to the LSA2-L2 protocol, modified by inclusion of cranial irradiation for @entity0 in stage III and stage IV disease. According to the staging system proposed by Wollner, 4 @entity0 were in stage I, 8 in stage II, 11 in stage III, 8 in stage @entity4 (less than or equal to 25% blasts in the bone marrow), 15 in stage IVB (greater than 25% blasts in the bone marrow), and 2 in @entity5 . The complete remission rate was 95.8%. The relapse-free survival (RFS) rate of 46 complete responders was 76% after a median observation time of 47+ months. Only 1 of 35 high-risk responder @entity0 developed CNS relapse after prophylactic treatment. Clinical stages were related to the RFS: 100% in stage I-II vs. 69% in stage III-IV. All 8 @entity0 in stage IV were alive without evidence of disease with a median observation time of 59+ months. Fifteen @entity0 in stage IVB who had @entity1 attained 59% RFS with a median observation time of 39+ months. After a median observation time of 38+ months, 29 of 37 @entity0 are off therapy. The results emphasize the value of both the histologic and immunologic features and the stage of disease in predicting the outcome of @entity3 in @entity0 . The LSA2-L2 regimen appears to be a very effective protocol for @entity0 with @entity2 , although it may be less efficacious for @entity0 with large bone marrow involvement.

title: @entity3 and " XXXX ": long-term results with the modified LSA2-L2 protocol.

answer: @entity1


abstract: From June 1976 to December 1984, 48 previously untreated @entity0 with @entity3 ( @entity3 ) were treated according to the LSA2-L2 protocol, modified by inclusion of cranial irradiation for @entity0 in stage III and stage IV disease. According to the staging system proposed by Wollner, 4 @entity0 were in stage I, 8 in stage II, 11 in stage III, 8 in stage @entity4 (less than or equal to 25% blasts in the bone marrow), 15 in stage IVB (greater than 25% blasts in the bone marrow), and 2 in @entity5 . The complete remission rate was 95.8%. The relapse-free survival (RFS) rate of 46 complete responders was 76% after a median observation time of 47+ months. Only 1 of 35 high-risk responder @entity0 developed CNS relapse after prophylactic treatment. Clinical stages were related to the RFS: 100% in stage I-II vs. 69% in stage III-IV. All 8 @entity0 in stage IV were alive without evidence of disease with a median observation time of 59+ months. Fifteen @entity0 in stage IVB who had @entity1 attained 59% RFS with a median observation time of 39+ months. After a median observation time of 38+ months, 29 of 37 @entity0 are off therapy. The results emphasize the value of both the histologic and immunologic features and the stage of disease in predicting the outcome of @entity3 in @entity0 . The LSA2-L2 regimen appears to be a very effective protocol for @entity0 with @entity2 , although it may be less efficacious for @entity0 with large bone marrow involvement.

title: XXXX and " @entity1 ": long-term results with the modified LSA2-L2 protocol.

answer: @entity3


abstract: The MC-2 @entity3 , which is a transplantable @entity1 syngeneic for BALB/c @entity2 , metastasizes to lymph nodes draining subcutaneous inoculation sites, and also to the lungs. T cell-mediated immunity was detected in Winn assays using spleens from excision immunized @entity2 . T cell-mediated anti- @entity1 immunity was also detected in spleens from @entity2 with small @entity1 but disappeared as the @entity1 burden increased. Protective immune spleen cell activity in the Winn assay was inhibited by prior addition of spleen cells from @entity2 with large @entity1 , causing increased @entity1 incidence. Splenic metastases occasionally occurred in the MC-2 model, but were not demonstrable by bioassay in any of the experiments detecting splenic suppressor cell activity. In vivo protective activity was restored to advanced-stage @entity1 -bearer spleens by whole-body ionizing irradiation (0.5 and 2.5 Gy) of donor @entity2 15 h before sampling. Spleen cells from @entity2 with small @entity1 remained protective after 1.5, 2.5 and 4.0 Gy of irradiation in vivo. These results are consistent with the properties of radiosensitive suppressor T cells. In contrast to reports in other @entity1 models, suppressor cells were not detected until late in the course of MC-2 development. This is surprising in view of the aggressively metastatic nature of MC-2. It is postulated that modulation of the anti- @entity1 immune response by the suppressor cells is associated with @entity0 in this @entity1 model. The late appearance of both suppressor cells and metastatic cells in the spleen may reflect similar processes occurring earlier in regional lymph nodes.

title: In vivo detection and partial characterization of effector and suppressor cell populations in spleens of @entity2 with large metastatic XXXX .

answer: @entity3


abstract: The MC-2 @entity3 , which is a transplantable @entity1 syngeneic for BALB/c @entity2 , metastasizes to lymph nodes draining subcutaneous inoculation sites, and also to the lungs. T cell-mediated immunity was detected in Winn assays using spleens from excision immunized @entity2 . T cell-mediated anti- @entity1 immunity was also detected in spleens from @entity2 with small @entity1 but disappeared as the @entity1 burden increased. Protective immune spleen cell activity in the Winn assay was inhibited by prior addition of spleen cells from @entity2 with large @entity1 , causing increased @entity1 incidence. Splenic metastases occasionally occurred in the MC-2 model, but were not demonstrable by bioassay in any of the experiments detecting splenic suppressor cell activity. In vivo protective activity was restored to advanced-stage @entity1 -bearer spleens by whole-body ionizing irradiation (0.5 and 2.5 Gy) of donor @entity2 15 h before sampling. Spleen cells from @entity2 with small @entity1 remained protective after 1.5, 2.5 and 4.0 Gy of irradiation in vivo. These results are consistent with the properties of radiosensitive suppressor T cells. In contrast to reports in other @entity1 models, suppressor cells were not detected until late in the course of MC-2 development. This is surprising in view of the aggressively metastatic nature of MC-2. It is postulated that modulation of the anti- @entity1 immune response by the suppressor cells is associated with @entity0 in this @entity1 model. The late appearance of both suppressor cells and metastatic cells in the spleen may reflect similar processes occurring earlier in regional lymph nodes.

title: In vivo detection and partial characterization of effector and suppressor cell populations in spleens of XXXX with large metastatic @entity3 .

answer: @entity2


abstract: The aim of this study was the @entity1 occurring within T-cell subsets of @entity2 ' @entity0 before treatment. Special emphasis was placed on the enumeration of activated T cells using a number of new monoclonal antibodies. Lymphocytes from 22 @entity2 @entity0 were examined. The total number, the percentage of 'helper/inducer' and 'suppressor/cytotoxic' positive cells were evaluated using the antibodies T3, T4 and UCHT4, whereas the cells with killer activity were defined by H25. @entity3 cells were detected using the antibodies DA6.231, DA6.164, and L243 which bind different epitopes of the beta chains of class II surface antigens and 4F2, which binds a 120,000 molecular weight glycoprotein. The results show no significant change in the total T, helper or suppressor cell phenotype, but an increase in the killer cell percentage was noted. Of those @entity0 tested, 19 of 22 showed an increase in activated T cells, 18 of 22 @entity0 showed a significant increase of T cells bearing class II antigens, 11 of 22 showed an increase of T cells staining with another activated T cell antibody, 4F2. The anti-DR antibodies expressed different binding characteristics, the most striking difference being seen between the antibodies DA6.231 and L243. The results of this study suggest an heterogeneity of the immune response, or differences in activation stage in @entity0 with @entity2 before therapeutic intervention. An important role for these cells in the pathogenesis of this disorder can be inferred.

title: XXXX cells in @entity2 before treatment.

answer: @entity3


abstract: The aim of this study was the @entity1 occurring within T-cell subsets of @entity2 ' @entity0 before treatment. Special emphasis was placed on the enumeration of activated T cells using a number of new monoclonal antibodies. Lymphocytes from 22 @entity2 @entity0 were examined. The total number, the percentage of 'helper/inducer' and 'suppressor/cytotoxic' positive cells were evaluated using the antibodies T3, T4 and UCHT4, whereas the cells with killer activity were defined by H25. @entity3 cells were detected using the antibodies DA6.231, DA6.164, and L243 which bind different epitopes of the beta chains of class II surface antigens and 4F2, which binds a 120,000 molecular weight glycoprotein. The results show no significant change in the total T, helper or suppressor cell phenotype, but an increase in the killer cell percentage was noted. Of those @entity0 tested, 19 of 22 showed an increase in activated T cells, 18 of 22 @entity0 showed a significant increase of T cells bearing class II antigens, 11 of 22 showed an increase of T cells staining with another activated T cell antibody, 4F2. The anti-DR antibodies expressed different binding characteristics, the most striking difference being seen between the antibodies DA6.231 and L243. The results of this study suggest an heterogeneity of the immune response, or differences in activation stage in @entity0 with @entity2 before therapeutic intervention. An important role for these cells in the pathogenesis of this disorder can be inferred.

title: @entity3 cells in XXXX before treatment.

answer: @entity2


abstract: The b-CAPSA I capsular polysaccharide vaccine for @entity1 type b was given to 87,541 @entity0 2 through 5 years of age in the Kaiser Permanente Medical Care Program, and the @entity0 were then followed using a multiple modality surveillance. Phase 1 consisted of 24-hour recall of immediate side effects which were recorded on questionnaires given to families of 13,500 @entity0 . Local side effects were found to be uncommon: 2.3% had a temperature of greater than or equal to 38.3 degrees C (greater than or equal to 101 degrees F); 4.8% had local erythema, 2.9% local swelling, and 12.6% local tenderness; two @entity0 had wheezing shortly after immunization. In Phase 2, 30 days after immunization, questionnaires were mailed to parents of all 87,541 @entity0 , who were asked to respond to questions about illnesses and health care. Phase 3 consisted of active surveillance of @entity0 health care use by physicians and nurses during the 30 days after immunization. During the 30-day reporting periods, there were 40 hospitalizations, including one for wheezing and one for febrile @entity2 . Of the 40 hospitalizations, only the one for wheezing was believed by the admitting physician to be probably associated with vaccine administration. Three @entity0 had @entity2 within 30 days of immunization. None of the @entity2 was believed by the reporting physician to be associated with immunization. Adverse effects of the vaccine were mild, limited to local reactions and occasional temperature elevation; @entity3 after immunization occurred rarely.

title: b-CAPSA I XXXX , type b, capsular polysaccharide vaccine safety.

answer: @entity1


abstract: UNASSIGNED: @entity3 ( @entity3 ) is the second frequent @entity0 . @entity2 ( @entity2 ) takes precedence over @entity3 . @entity2 is a metaplastic change of the stratified squamous epithelium to the intestinal columnar epithelium due to the @entity1 . Further, the disease takes the @entity4 stage followed by @entity3 . An initial immune response is an essential reaction of a body to an occurrence of alien/modified cells to be removed. It has been appreciated that an inflammatory reaction occurs in the early stages of @entity3 or even in @entity2 . Dendritic cells (DCs) play a key role in a frontier of an immune response due to their advanced ability to recognize foreign antigens and mobilize naive T cells to effectors. However, in a @entity0 , @entity0 -delivered immunosuppression occurs in a variety of mechanisms that alter/switch the functionality of DCs from immune activating to immune suppressive cells. In this brief review, we consider @entity0 -induced paths of a capacity of @entity0 cells to down-regulate DCs, with a focus on @entity3 , and also discuss a possibility to use DCs for immunotherapeutic approaches. Indeed, DCs represent a promising tool for developing new immunotherapeutic approaches for @entity0 treatment including @entity3 . It has been reported to achieve effective DC-mediated immune responses by raising anti- @entity0 cytotoxic T cell responses against @entity0 antigens through loading DCs with total @entity0 RNA. However, more studies should be performed in order to understand a precise role in @entity0 -induced mechanisms of DC suppression in @entity2 / @entity3 . Likely, these mechanisms should involve general carcinogenic and @entity3 -specific pathways.

title: Dendritic Cells in XXXX : The Currently Available Information and Possibilities to use Dendritic Cells for Immunotherapeutic Approaches.

answer: @entity3


abstract: The results are presented of a prospective study of the course of 283 spinal cord-injured @entity0 who were consecutively admitted to five @entity1 centers participating in the Comprehensive Central @entity4 Centers' program of the National Institutes of Health. Of the 283 @entity0 , 14 deteriorated neurologically during acute hospital management. In 12 of the 14, the decline in neurological function could be associated with a specific management event, and in nine of these 12 the injury involved the cervical cord. Nine of the 14 @entity0 who deteriorated had cervical injuries, three had @entity3 , and two had thoracolumbar junction injuries. Management intervention was identified as the cause of deterioration in four of 134 @entity0 undergoing operative intervention, in three of 60 with skeletal traction application, in two of 68 with halo vest application, in two of 56 undergoing Stryker frame rotation, and in one of 57 undergoing @entity2 . Early surgery on the cervical spine when @entity3 is present appears hazardous, since each of the three @entity0 with a cervical @entity3 who deteriorated was operated on within the first 5 days. No such deterioration was observed following surgery performed from the 6th day on. In two other @entity0 , deterioration did not appear to be related to management but was a direct product of the underlying disease or of systemic complications. Deterioration following hospitalization for @entity3 is relatively uncommon--4.9% in this large series. In most instances, decline in function could be attributed to specific management procedures. These changes must not be interpreted as representing failure to provide optimal care but rather should be seen as the inevitable product of an attempt to manage @entity0 with spinal cord and column injuries, many of which are clearly unstable.

title: Deterioration following XXXX . A multicenter study.

answer: @entity3


abstract: PURPOSE: To evaluate the intraocular pressure (IOP) lowering effect of the XEN140 microfistula gel stent implant for the surgical treatment of @entity4 . @entity0 AND METHODS: Forty-nine eyes of 49 @entity0 with an IOP>18 mm Hg and  <=35 mm Hg were studied in a prospective nonrandomized multicenter cohort trial of the surgical implantation of the XEN140 implant in @entity0 with @entity4 . Complete success was defined as a postoperative IOP <=18 mm Hg with >= 20% reduction in IOP at 12 months without any @entity2 medications. Failure was defined as @entity1 or worse, need for additional @entity2 surgery, or <20% reduction of IOP from baseline. RESULTS: The average age was 64.3 (28.1 to 86.9) years old. Twenty-one eyes had prior failed trabeculectomy with @entity3 surgery. IOP at 12 months decreased from a mean of 23.1 (  4.1) mm Hg to 14.7 (  3.7) mm Hg for a 36.4% reduction in IOP from baseline. The number of @entity0 at 12 months who achieved an IOP <=18 mm Hg and >= 20% reduction in IOP was 40 (89%). The number of @entity0 who achieved an IOP <=18 mm Hg and >= 20% reduction in IOP without antiglaucoma medications was 18 (40%). CONCLUSIONS: The XEN140 gel stent lowers IOP with few complications when implanted for the surgical treatment of @entity4 .

title: Early Clinical Results of a Novel Ab Interno Gel Stent for the Surgical Treatment of XXXX .

answer: @entity4


abstract: UNASSIGNED: Epigenetic complexes control various pathways within the cells. Their abnormalities can be involved in the initiation and the progression of different types of @entity2 . Nucleosome remodeling and deacetylase (NuRD) is an epigenetic complex that comprises several subunits such as @entity4 . Although @entity4 is reported as a @entity2 suppressor in some of the @entity3 , its function is still challenging in other @entity2 . Our study aimed at investigating the role of @entity4 in different types of @entity2 . We conducted a meta-analysis of @entity4 in @entity1 @entity2 at genomic, transcriptomic, and proteomic levels. For this purpose, we acquired the data from several databases, and tried to statistically integrate and analyze the data in order to find the potential role of @entity4 in different @entity2 . The results demonstrated that although @entity4 has been previously known as a @entity2 suppressor gene, it was remarkably overexpressed in many @entity0 . Notably, @entity4 was under-expressed in a few types of @entity2 , including @entity2 . Moreover, the results indicated that although the mutation rate of @entity4 is relatively low, it is mutated in some @entity2 types.   In addition, our data for 40 epigenetic genes showed that missense and nonsense mutations were associated with overexpression and under-expression, respectively. Our results suggest that @entity4 may function as an oncogenic factor in several types of @entity2 . We also hypothesize that @entity4 may also play its role in a tissue-specific manner. Our findings suggest further investigations regarding the exact role of @entity4 in @entity2 types.

title: The potential role of XXXX as an oncogene: a genotranscriptomic/proteomic meta-analysis.

answer: @entity4


abstract: One hundred eight-five @entity0 with potentially operable @entity1 were prospectively evaluated by computed tomographic scanning of the mediastinum and upper part of the abdomen. Mediastinal lymph node size was correlated with operative and pathologic findings. There was close agreement between computed tomographic estimate of size and operative measurements. Mediastinal lymph nodes that were larger than 2.0 cm were positive for @entity2 in 69.6%, nodes between 1.1 and 1.9 cm contained metastases in 31.8%, and nodes less than 1.0 cm were positive in only 2.7%. The cell type, T status, and location of the @entity2 did not influence these findings: A node less than 1.0 cm with a T3 lesion had the same probability of being abnormal as with a T1 lesion, although predictably, those @entity0 with @entity2 had a greater likelihood of having nodes larger than 2.0 cm. The presence of @entity3 did not increase the prevalence of enlarged, histologically normal nodes. Asymptomatic adrenal metastases were present in 3.2% of @entity0 with otherwise operable disease and were suggested only by the computed tomographic scan. @entity0 with mediastinal nodes less than 1.0 cm probably do not need preresection mediastinal exploration. Those with nodes larger than 2.0 cm should not be considered unresectable without pathologic confirmation, even in large @entity2 , in view of the 30.4% negativity rate. The computed tomographic scan is useful in depicting and localizing enlarged mediastinal nodes but cannot be used as a substitute for pathologic examination.

title: Prospective computed tomographic scanning in the staging of XXXX .

answer: @entity2


abstract: UNASSIGNED: The @entity1 -inducible factor (HIF) family has three distinct members in most vertebrates. All three HIFs consist of a unique and @entity0 -labile a subunit and a common and stable b subunit. While @entity2 and HIF-2 function as master regulators of the transcriptional response to @entity1 , much less is known about HIF-3. The @entity3 gene gives rise to multiple @entity3 variants due to the utilization of different promoters, different transcription initiation sites, and alternative splicing. These @entity3 variants are expressed in different tissues, at different developmental stages, and that they are differentially regulated by @entity1 and other factors. Recent studies suggest that different @entity3 variants have different and even opposite functions. There is strong evidence that full-length @entity3 protein functions as an @entity0 -regulated transcription activator and it activates a unique transcriptional program in response to @entity1 . Many @entity3 target genes have been identified. While some short @entity3 variants act as dominant negative regulators of @entity2 /2a actions, other @entity3 variants can inhibit @entity2 /2a actions by competing for the common HIF-b. There are also a number of @entity3 variants yet to be explored. Future studies of these naturally occurring @entity3 variants will provide new and important insights into HIF biology and may lead to the development of new therapeutic strategies.

title: XXXX -inducible factor 3 biology: Complexities and emerging themes.

answer: @entity1


abstract: OBJECTIVE: In the breast, @entity4 is expressed by myoepithelial cells (MECs), and apocrine @entity6 has also been mentioned as being positive with this marker. Apocrine lesions have been explored for the expression of @entity4 . METHODS: The apocrine lesions studied included 11 cysts, 6 cases of apocrine adenosis, 2 of apocrine @entity6 or @entity3 in @entity2 , 13 @entity5 ( @entity5 ) and invasive @entity1 (14 ductal and 4 lobular). RESULTS: Benign apocrine lesions showed complete or partial luminal @entity4 staining, although most cases included parts without staining, and 2 lesions were completely negative. The MECs were often but not always positive. Nine of the 13 cases of apocrine @entity5 displayed no luminal staining, but 4 demonstrated very focal luminal positivity. The MECs around the @entity5 showed a spectrum of staining from nil to strong and complete. Only 4 invasive @entity1 demonstrated luminal/membranous staining. Cytoplasmic @entity4 positivity was seen focally in 4 invasive @entity0 and in 3 @entity5 . CONCLUSION: @entity4 positivity is luminal/membranous in most benign apocrine lesions, the staining being nonuniversal and sometimes focal. Analogous staining in apocrine @entity0 seems rarer in @entity5 and even rarer in invasive @entity1 , but atypical cytoplasmic positivity may also occur. @entity4 is not an ideal myoepithelial marker in apocrine lesions.

title: XXXX Immunohistochemical Expression in Apocrine Lesions of the Breast.

answer: @entity4


abstract: UNASSIGNED: Purpose: To correlate key inflammatory and pro-angiogenic cytokines from undiluted vitreous fluid of treatment-na  ve @entity0 with central @entity8 (CRVO) with SD-OCT parameters. Methods: Thirty-five @entity0 (age 71.1 years, 24 phakic, 30 non-ischaemic) underwent intravitreal combination therapy, including single-site 23-gauge core vitrectomy. Twenty-eight samples from @entity0 with idiopathic, non-uveitis floaterectomy served as controls. Levels of @entity3 ( @entity3 ), @entity7 ( @entity7 ), and @entity1 ( @entity1 -A) were correlated with @entity2 (logMar), category of CRVO (ischaemic or non-ischaemic) and morphological parameters, such as @entity4 ( @entity4 ), thickness of @entity6 (Tneuro), extent of @entity5 ( @entity5 ) and disintegrity of the IS/ @entity9 and others. Results: Mean @entity3 was 64.7   pg/ml (SD      115.8), mean @entity7 1015.7   pg/ml (     970.1), and mean @entity1 278.4   pg/ml (     512.8), which was significantly higher than the control values of @entity3 6.2        3.4   pg/ml (p   =   0.06), @entity7 253.2        73.5   pg/ml (p   <   0.0000001) and @entity1 7.0        4.9   pg/ml (p   <   0.0006), respectively. All cytokines correlated highly with one another (correlation coefficient r   =   0.82 for @entity3 and @entity7 ; r   =   0.68 for @entity3 and @entity1 ; r   =   0.64 for @entity7 and @entity1 ). @entity3 correlated significantly with @entity4 , TRT, @entity5 , dIS/ @entity9 , and dELM. @entity7 correlated significantly with @entity5 , dIS/ @entity9 , and dELM. @entity1 did not correlate with changes in SD-OCT, while it had a trend to be higher in the ischaemic versus the non-ischaemic CRVO groups (p   =   0.09). Conclusions: The inflammatory cytokines were more often correlated with morphological changes assessed by SD-OCT, whereas @entity1 did not correlate with CRVO-associated changes in SD-OCT. @entity1 inhibition alone may not be sufficient to decrease the inflammatory response in CRVO therapy.

title: [Correlation from Undiluted Vitreous Cytokines of Untreated Central XXXX with Spectral Domain Optical Coherence Tomography].

answer: @entity8


abstract: RATIONALE: Surgical lung biopsy is often required for a confident multidisciplinary diagnosis of @entity4 ( @entity4 ). Alternative, less-invasive biopsy methods, such as @entity2 ( @entity2 ), are highly desirable. OBJECTIVES: To address the impact of @entity2 on diagnostic confidence in the multidisciplinary diagnosis of @entity4 . METHODS: In this cross-sectional study we selected 117 @entity0 with fibrotic @entity3 without a typical @entity4 pattern on high-resolution computed tomography. All cases underwent lung biopsies: 58 were @entity2 , and 59 were surgical lung biopsy (SLB). Two clinicians, two radiologists, and two pathologists sequentially reviewed clinical-radiologic findings and biopsy results, recording at each step in the process their diagnostic impressions and confidence levels. MEASUREMENTS AND MAIN RESULTS: We observed a major increase in diagnostic confidence after the addition of @entity2 , similar to SLB (from 29 to 63%, P   =   0.0003 and from 30 to 65%, P   =   0.0016 of high confidence @entity4 diagnosis, in the @entity2 group and SLB group, respectively). The overall interobserver agreement in @entity4 diagnosis was similar for both approaches ( @entity2 overall kappa, 0.96; SLB overall kappa, 0.93). @entity4 was the most frequent diagnosis (50 and 39% in the @entity2 and SLB group, respectively; P   =   0.23). After the addition of histopathologic information, 17% of cases in the @entity2 group and 19% of cases in the SLB group, mostly idiopathic nonspecific @entity3 and @entity1 , were reclassified as @entity4 . CONCLUSIONS: @entity2 is a new biopsy method that has a meaningful impact on diagnostic confidence in the multidisciplinary diagnosis of @entity3 and may prove useful in the diagnosis of @entity4 . This study provides a robust rationale for future studies investigating the diagnostic accuracy of @entity2 compared with SLB.

title: Bronchoscopic Lung Cryobiopsy Increases Diagnostic Confidence in the Multidisciplinary Diagnosis of XXXX .

answer: @entity4


abstract: UNASSIGNED: @entity7 are complex phenolic polymers with limited industrial uses. To identify new applications of @entity7 , this study aims to evaluate the conifer @entity1 lignin as a potential antioxidant for @entity6 , using the petroleum asphalt as an example. Using the @entity0 ( @entity0 ) method, the evaluation is accomplished by tracking the generation of critical species in a lignin-asphalt mixture under a simulated oxidative condition. The generation of new species was detected using nuclear magnetic resonance and four analytical methods including density of states analysis, highest occupied molecular orbital and lowest unoccupied molecular orbital analyses, bonding and energy level analysis, and electrostatic potential energy analysis. Results of the analyses show that the chemical radicals of @entity2 , @entity4 and @entity3 generated in the oxidation process could enhance the agglomeration and/or decomposition tendency of asphalt. The effectiveness of @entity7 as an antioxidant depends on their chemical compositions. @entity7 with a HOMO-LUMO gap larger than the HOMO-LUMO gap of the @entity5 system to be protected, such as the conifer @entity1 lignin to protect petroleum asphalt as was studied in this work, do not demonstrate beneficial anti-oxidation capacity. @entity7 , however, may be effective oxidants for @entity5 systems with a larger HOMO-LUMO gap. In addition, @entity7 may contain more polar sites than the @entity6 to be protected; thus the @entity7 ' hydrophobicity and compatibility with the host @entity6 need to be well evaluated. The developed @entity0 model provides a useful tool for developing antioxidants for generic @entity6 .

title: An XXXX analysis of lignin as a potential antioxidant for @entity6 .

answer: @entity0


abstract: UNASSIGNED: @entity7 are complex phenolic polymers with limited industrial uses. To identify new applications of @entity7 , this study aims to evaluate the conifer @entity1 lignin as a potential antioxidant for @entity6 , using the petroleum asphalt as an example. Using the @entity0 ( @entity0 ) method, the evaluation is accomplished by tracking the generation of critical species in a lignin-asphalt mixture under a simulated oxidative condition. The generation of new species was detected using nuclear magnetic resonance and four analytical methods including density of states analysis, highest occupied molecular orbital and lowest unoccupied molecular orbital analyses, bonding and energy level analysis, and electrostatic potential energy analysis. Results of the analyses show that the chemical radicals of @entity2 , @entity4 and @entity3 generated in the oxidation process could enhance the agglomeration and/or decomposition tendency of asphalt. The effectiveness of @entity7 as an antioxidant depends on their chemical compositions. @entity7 with a HOMO-LUMO gap larger than the HOMO-LUMO gap of the @entity5 system to be protected, such as the conifer @entity1 lignin to protect petroleum asphalt as was studied in this work, do not demonstrate beneficial anti-oxidation capacity. @entity7 , however, may be effective oxidants for @entity5 systems with a larger HOMO-LUMO gap. In addition, @entity7 may contain more polar sites than the @entity6 to be protected; thus the @entity7 ' hydrophobicity and compatibility with the host @entity6 need to be well evaluated. The developed @entity0 model provides a useful tool for developing antioxidants for generic @entity6 .

title: An @entity0 analysis of lignin as a potential antioxidant for XXXX .

answer: @entity6


abstract: The long-term functional results of splinting a collapsing major airway with a silastic Marlex mesh prosthesis were assessed. Six @entity0 in whom follow-up has been longer than 4 years (mean 5.3 years) were studied. The prosthetic semirigid splints had been implanted in five @entity0 with @entity1 and one with @entity2 . Mean age at the time of airway splinting was 4 years (range 6 months to 8 years). At their last clinical evaluation, all six @entity0 were leading normal active lives. Three had mild respiratory symptoms not related to the splinting. The only long-term complication was a serous effusion that developed around the splint and compressed the @entity1 in one @entity0 2 years postoperatively. Tracheal fluoroscopy, barium swallow, and computed tomography scans of the @entity1 in five @entity0 demonstrated satisfactory tracheal caliber without airway collapse during expiration and coughing. Pulmonary function testing showed a mild increase in airway resistance in one @entity0 who had had a tracheostomy. These results demonstrate that the application of composite synthetic graft to a segment of a malacic airway in young @entity0 can provide long-term relief from airway collapse without compromising airway growth.

title: Long-term functional results of prosthetic airway splinting in @entity1 and XXXX .

answer: @entity2


abstract: The long-term functional results of splinting a collapsing major airway with a silastic Marlex mesh prosthesis were assessed. Six @entity0 in whom follow-up has been longer than 4 years (mean 5.3 years) were studied. The prosthetic semirigid splints had been implanted in five @entity0 with @entity1 and one with @entity2 . Mean age at the time of airway splinting was 4 years (range 6 months to 8 years). At their last clinical evaluation, all six @entity0 were leading normal active lives. Three had mild respiratory symptoms not related to the splinting. The only long-term complication was a serous effusion that developed around the splint and compressed the @entity1 in one @entity0 2 years postoperatively. Tracheal fluoroscopy, barium swallow, and computed tomography scans of the @entity1 in five @entity0 demonstrated satisfactory tracheal caliber without airway collapse during expiration and coughing. Pulmonary function testing showed a mild increase in airway resistance in one @entity0 who had had a tracheostomy. These results demonstrate that the application of composite synthetic graft to a segment of a malacic airway in young @entity0 can provide long-term relief from airway collapse without compromising airway growth.

title: Long-term functional results of prosthetic airway splinting in XXXX and @entity2 .

answer: @entity1


abstract: BACKGROUND: Asthma is one of the most common @entity1 in @entity0 . The unpredictability, frequency, and health risks associated with acute @entity2 attacks have a profound impact on the daily lives of affected @entity0 and their families. Understanding the experiences of primary caregivers may help nurses provide better care to @entity0 with @entity2 . PURPOSE: This study explores the experience of primary caregivers in providing care to @entity0 with @entity2 . METHODS: The study used exploratory and descriptive research methods and collected data using a qualitative research interview approach. Seventeen primary caregivers of @entity0 with @entity2 who visited the @entity3 clinics of two medical centers and one regional hospital in northern Taiwan participated in the study. An interview guide with a semistructured questionnaire was used, and verbatim transcripts of the audiotape-recorded interviews were analyzed using content analysis. RESULTS: The findings are described in three themes covering 10 categories. These themes and categories include feelings of uncertainty during illness (disease as perception related, lack of information), feelings of chaos and instability (worry, fear, frustration, helplessness, physical distress), and social tension and family conflict (disorientation of daily activity and burden of care, economic burden, family tensions and disagreements). CONCLUSIONS: Negative experiences with @entity2 care and the unpredictability of the disease outcomes impair the ability of caregivers to adapt successfully to their caregiving role and encourage perceptions that they cannot cope with this illness. Better understanding the caregiver experience may assist healthcare providers to better target support to these caregivers so that they are better able to care for @entity0 with @entity2 .

title: The Stress of Caring for XXXX With Asthma: A Qualitative Study of Primary Caregivers.

answer: @entity0


abstract: We attempted to identify all cases of @entity2 which occurred in two health districts in the UK during a 56 month period. The crude incidence was 8.9 cases/100,000 @entity0 . One hundred and twenty cases and 119 age-matched controls were interviewed to identify risk factors for this disease. In addition, 137 mothers completed postal questionnaires. Cases were older at leaving school, had higher social class occupations, were more often unmarried or married late, and had fewer @entity0 than controls. Oral contraceptive use was similar for both. Cases reported more exercise at all ages, and more alcohol consumption 1 year before diagnosis. Cases' mothers reported slightly less @entity4 during pregnancy than controls' mothers, and none of the mothers reported exogenous hormone exposure during the index pregnancy. In this study benign @entity2 strongly resemble @entity1 in their age distribution in the population. They also resemble @entity1 in their association with educational status and marital status. There was, however, no similarity regarding prenatal hormone exposure. The increased risks associated with exercise and @entity3 use were unexpected; we need further information about how these exposures affect the ovary, and whether they affect the testis.

title: XXXX : a population-based case-control study.

answer: @entity2


abstract: We describe four @entity0 with bilateral @entity5 progressing to diffuse @entity2 for which we have been unable to find any evidence of an infective, embolic or occupational aetiology. In order to avoid @entity4 with diffuse @entity2 attributable to @entity6 -related disease, the term cryptogenic bilateral fibrosing @entity7 is suggested. The @entity0 differed from those with @entity2 due to @entity6 in that none of them gave a history of @entity6 exposure, all were ill, presented with @entity3 which was not always pleuritic in character, and had dyspnoea, cough or malaise. They had @entity5 of variable size, @entity2 radiographically and raised sedimentation rates. Computed tomography revealed bilateral extensive @entity2 in all cases. All four were HLA B44 positive. Histology showed that in all cases the pleura was thickened by fibrous tissue. Both layers were affected and the pleural space was often obliterated. Otherwise the pleural surface was covered by organizing fibrin. Focal collections of lymphocytes were often present when the fibrous tissue abutted on the subpleural fat. No @entity6 bodies were seen in any of the cases and in one @entity0 electron microscopic fibre counts showed no excess of @entity6 . Pleural decortication was successful in three @entity0 . In one of these, contralateral disease was successfully controlled with corticosteroids, but the fourth @entity0 has not improved on @entity1 .

title: Cryptogenic bilateral fibrosing XXXX .

answer: @entity7


abstract: Sixteen @entity0 with @entity2 were skin tested with their own serum, IO with autologous plasma and five with serum that had been heated to 56 degrees C to inactivate complement. Eight showed a weal and flare response to whole serum, four to plasma and five to heat-treated serum. All serum-positive @entity0 showed the same response to their own plasma and to heated serum, indicating that the mediator concerned is not generated by clotting and is not dependent on a functioning complement pathway. Three control subjects were negative to autologous serum, plasma and heated serum. @entity1 was demonstrated in five serum-positive @entity0 on reinjection of the same site with autologous serum on 3 consecutive days. This raises the possibility that the serological mediator may be acting by mast cell degranulation or directly on receptors in blood vessels and that repeated injections could induce a change in the number of receptors. Passage of whole autologous serum from four serum-positive @entity0 through ultrafiltration membranes showed that fractions with a molecular weight of less than 30,000 daltons were still able to produce a positive skin test response, but those less than 1000 daltons were not. All serum fractions from two serum-negative @entity0 and three normal controls were negative. Whole autologous serum from five serum-positive @entity0 and two control subjects were separated by column chromatography. On skin testing with pooled fractions, the greatest response was produced by fractions of 10,000-15,000 daltons in the serum-positive @entity0 , but there was no response in the controls.

title: Preliminary identification of a low molecular weight serological mediator in XXXX .

answer: @entity2


abstract: Purpose. In this report, we investigated the protective mechanism of @entity7 ( @entity6 ) in vitro and in vivo which could be involved in endothelial @entity5 -dependent protein kinase (PKG), @entity8 ( @entity8 ) pathway, and vascular endothelium dysfunction (EtD). Method. @entity0 brain microvascular endothelial cells (HBMECs) with @entity3 reoxygenation (HR) treatment and @entity1 with @entity4 reperfusion (CIR) treatment were applied. Protein and mRNA expression of PKG, @entity8 , and p- @entity8 were evaluated by Western blot and RT-PCR methods. Vascular EtD was assessed by using wire myography to determine endothelium-dependent vasorelaxation in isolated @entity1 basilar artery (BA). Result. In cultured HBMECs, @entity6 (0.1, 1, and 10    M) increased cell viability, mRNA, protein level, and phosphorylative activity of PKG and @entity8 against @entity3 . In HR model of BA, @entity6 increased protein level of P- @entity8 . In @entity1 CIR model, wire myography demonstrated that @entity6 (45 and 90   mg/kg, i.v.) significantly reduced @entity2 size by partially restoring the endothelium dependent vasodilation of BA; PKG inhibitor @entity9 (50    g/kg, i.v.) reversed this protection of @entity6 in CIR @entity1 . Conclusion. @entity6 protects against cerebral vascular EtD through endothelial PKG pathway activation.

title: XXXX Reduces Endothelium Dysfunction through the PKG-I Pathway.

answer: @entity7


abstract: BACKGROUND: The purpose of the study was to clarify the usefulness of positron emission tomography-computed tomography (PET-CT) for pre-operative evaluation of @entity3 , especially in terms of regional lymph node status. METHODS: Medical records of 93 consecutive cases from July 2007 to October 2012 were retrospectively reviewed. All @entity0 underwent curative and complete esophagectomies for @entity3 . We compared pre-operative maximum standard uptake values (SUVmax) of @entity2 and regional @entity5 ( @entity5 ) with other variables ( @entity4 , history of previous other primary @entity2 , gender, differentiation, and neoadjuvant therapy). In addition, the SUVmax of @entity2 and LNs were analyzed with pathologic findings. RESULTS: There was no significant difference of each @entity2 and @entity5 SUVmax according to factors including @entity4 , age, history of previous other @entity2 , differentiation, and gender. Pre-operative evaluations by PET-CT were not accurate ( @entity2 sensitivity 76.4%, specificity 25%; @entity5 sensitivity 45.2%, specificity 54.8%). Receiver operating characteristic analysis showed that @entity5 @entity1 could not be appropriately diagnosed with SUVmax (P   =   0.871). There was no difference in SUVmax between pathologically positive and negative @entity5 subgroups. Tumor SUVmax correlated with the progression of @entity3 in @entity0 without neoadjuvant therapy (P   <   0.001). However, @entity5 SUVmax had no correlation with overall pathologic stage. After neoadjuvant therapy, there were significant decreases in SUVmax in both pathologically positive and negative @entity5 subgroups (P   =   0.043, P   =   0.008). CONCLUSION: Surgery should not be withheld in N-stage according to PET-CT findings and carefully considered in conjunction with other conditions.

title: Usefulness of positron emission tomography-computed tomography in pre-operative evaluation of XXXX .

answer: @entity3


abstract: Newborn screening for @entity8 has been recommended as a method of decreasing @entity0 mortality. However, its effectiveness in accomplishing this has not been reliably measured. To help determine the effectiveness, 10 years of experience in newborn screening have been summarized. The effects of early @entity0 enrollment in a comprehensive treatment program on long-term morbidity and mortality are reported. From 1975 to 1985, 84,663 newborns were screened regardless of race or ethnic background. Bart's hemoglobin was present in 5%, hemoglobin AS in 2.6%, and hemoglobin AC in 0.75%. Excluding Bart's, approximately 3.6% of all newborns were carriers for @entity10 . @entity8 occurred in 1:951 births (58 hemoglobin SS, 25 hemoglobin FSC, three hemoglobin S-beta +- @entity7 , and three hemoglobin S-beta @entity7 ). In addition, one in every 4,233 newborns had a clinically significant @entity7 (eight hemoglobin FE, ten hemoglobin F only, two hemoglobin H). Compared with other newborn screening programs in California, ( @entity9 , 1:3,849; @entity5 1:22,474, @entity6 1:74,103), @entity10 are the most prevalent @entity1 . Eighty-one newborns with @entity8 were followed for 7.2 years. @entity0 experienced 513 hospitalizations, including 13 episodes of @entity3 with or without @entity4 and ten acute sequestration crises. The overall mortality rate for @entity0 with @entity8 diagnosed in the newborn period was 1.8%. In comparison, the clinical course of 64 @entity0 with @entity8 diagnosed after 3 months of age and followed for an average of 9.4 years was analyzed. Five of these @entity0 died. In two of these, @entity8 was diagnosed at the time of the @entity2 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Newborn screening for XXXX : effect on mortality.

answer: @entity8


abstract: OBJECTIVE: In the 7(th) edition of the TNM classification of @entity3 , the prognosis for pT4-M1a @entity3 is better than for stage pIIIB. Subgroups of @entity1 @entity0 who underwent incomplete resection (R1/R2) have a favorable prognosis. This study compares the prognosis between cases of invisible local residual disease and intrathoracic disseminated pT4-M1aIV. METHODS: @entity0 characteristics and histological and molecular profiles were retrospectively collected for @entity1 @entity0 who underwent resection intended to be curative but were accidentally incomplete. All @entity0 were divided into either a local residual group or an intrathoracic disseminated pT4M1a group. Progression-free survival (PFS) and @entity7 ( @entity7 ) were evaluated by Kaplan-Meier and Cox regression models. RESULTS: In total, 1,483 consecutive @entity1 @entity0 receiving thoracotomies at Guangdong @entity1 Institute were retrospectively analyzed. Fifty-eight @entity0 receiving incomplete resections (R1/R2) were enrolled, including 38 @entity0 with @entity3 (2.6% of all @entity0 ) and 20 @entity0 with disseminated pM1a (1.3%). @entity0 characteristics, and histological and molecular profiles of the two groups were different. Compared to the local residual group, the disseminated pT4-M1a group contained more females (P=0.002), more @entity0 younger than 60 years of age (P=0.028), more non-smokers (P=0.037), more @entity4 (20/20 vs. 20/38, P<0.001), more @entity4 with lepidic pattern (11/20 vs. 4/38, P<0.001), higher @entity6 ( @entity6 ) levels (P=0.06), higher @entity5 ( @entity5 ) mutation rates (16/20 vs. 7/38, P<0.001), a higher R2/R1 resection ratio (P=0.013), a higher advanced stage IV/IIIB ratio (P<0.001), but fewer lymph node @entity2 (P=0.013). Median PFS for the local residual and disseminated pT4-M1a groups was 9.0 and 18.0 months, respectively [95% confidence interval (CI), 5.285-16.715; P =0.099]. Median @entity7 was 15.0 and 45.0 months, respectively (95% CI, 18.972-39.028; P=0.001). Cox regression analysis revealed that group (local residual vs. disseminated pT4-M1a) was the only independent prognostic factor (P=0.044) for @entity7 . CONCLUSIONS: Accidental invisible intrathoracic disseminated pT4-M1a may be a distinct @entity1 subtype with a favorable prognosis. The prolonged PFS and @entity7 might reflect the natural history of this distinct subtype, together with a favorable response to @entity5 @entity8 kinase inhibitors ( @entity5 -TKI). For asymptomatic and slow-growing accidental pT4-M1a disease, the role of a wait-and-see strategy and the appropriate timing of systemic treatment require further investigation.

title: Accidental invisible intrathoracic disseminated pT4-M1a: a distinct XXXX with favorable prognosis.

answer: @entity1


abstract: OBJECTIVES: To review the current role of laparoscopy and robot-assisted laparoscopy for managing @entity4 . RESULTS: The contemporary indications for laparoscopic stone management are: anatomical variations in location or shape of the kidney ( @entity1 , @entity1 and @entity1 ); coexisting pathologies, e.g. @entity5 ; and stones in a renal unit with lower @entity3 . The laparoscopic approach allows the simultaneous management of both the pathologies. Symptomatic stones in diverticula not amenable to endourological intervention can be treated with laparoscopy. Large impacted pelvic and ureteric calculi with a functioning renal unit are an indication for laparoscopic ureterolithotomy or pyelolithotomy. This review of current reports suggests that in a selected group of @entity0 with complex stone disease the laparoscopic approach offers good success rates with minimal complications. There are few reports of robotic procedures in stone disease but existing data suggest that it is feasible. CONCLUSION: Laparoscopic surgery is effective for @entity2 and offers excellent stone clearance rates with minimal morbidity. Laparoscopic surgery is complementary in managing these stones. Robot-assisted laparoscopic technique of urinary tract stone management is in its early stage of implementation and randomised trials that compare robot assisted outcomes with other minimally invasive techniques are needed.

title: Laparoscopic and robot-assisted surgery in the management of XXXX .

answer: @entity4


abstract: OBJECTIVE: To evaluate the outcome of using commercially available (SIS) grafts for repairing @entity1 . Collagen-based acellular matrices, including SIS and bladder submucosa matrix, have been used to repair urethral strictures, with varying success, and @entity0 with @entity1 and with inadequate or no genital skin need a substitute tissue for urethroplasty. @entity0 AND METHODS: This pilot study included 12 @entity0 (mean age 8  years, range 1.5-15) with @entity1 (distal in six, mid-shaft in four and proximal in two). They underwent a repair with four layers of prefabricated SIS as an onlay graft. The outcome was assessed for cosmetic appearance, urinary stream and the postvoid residual volume. The chi-squared and Mann-Whitney U-tests were used to assess the relationship between preoperative factors and the outcome of the repair with SIS grafting. RESULTS: The mean (range) follow-up was 23 (6-36) months. Nine @entity0 ultimately voided normally, with a good cosmetic appearance and no postvoid residual urine. Six @entity0 had a successful repair with no further intervention, whilst three had small fistulae that were treated by simple closure. In three @entity0 the graft failed, by complete disruption or stricture. Graft infection adversely affected the outcome of SIS grafting. CONCLUSIONS: The prefabricated SIS graft can be used as an alternative substitute for urethral reconstruction when genital skin is insufficient or lacking, as in circumcised @entity0 or a @entity1 repair. Graft infection is the chief reason for graft failure and should be prevented. Further studies with more @entity0 are needed to confirm these preliminary results.

title: The use of small intestinal submucosa graft for XXXX repair: Pilot study.

answer: @entity1


abstract: Introduction. Few studies have examined the association between the PR interval (PRi) and subclinical @entity2 measures. Methods and Results. The Multiethnic Study of @entity3 (MESA) is a population-based study of 6814 @entity0 and @entity0 aged 45-84 years without clinical @entity2 and 4962 had complete baseline data on cardiac magnetic resonance imaging measures of LV dimension and ejection fraction and surface electrocardiogram. Linear regression models were constructed to determine the adjusted association between the PRi and measures of LV @entity1 volume, LV mass, LV end-systolic and end-diastolic volumes, and ejection fraction. Overall, mean age was 61.5 years, and 47.6% were male and race/ethnicity was white in 39.1%, Chinese in 13.1%, African-American in 25.7%, and Hispanic in 22.2%. The PRi ranged from 88 to 308   ms with a median value of 162   ms. As a continuous variable, every standard deviation unit (25   ms) increment in PRi was associated with a 2.00   mL (95% CI 1.52, 2.48) higher @entity1 volume, a 3.08   g (95% CI 2.30, 3.86) higher LV mass, a 1.36   g/m(2) (95% CI 0.96, 1.76) higher LV mass index, and 1.31   mL (95% CI 0.88, 1.73) higher end-systolic and 3.31   mL (95% CI 2.58, 4.03) higher end-diastolic volumes after adjustment for all covariates. No significant association was noted between the PRi and LV ejection fraction. Conclusions. A prolonged PRi is associated with LV measures and may in part explain the link between a prolonged PRi and cardiovascular outcomes.

title: The Association between the PR Interval and Left Ventricular Measurements in the Multiethnic Study of XXXX .

answer: @entity3


abstract: In @entity0 with acquired @entity3 detected by group cardiac examinations at school, we analyzed follow-up data obtained during school days as well as after graduation from senior high school. Of the 343 @entity0 followed up after graduation from senior high school up to an age range of 20-38 years (mean: 29.3 years), 18 (5.2%) died, 16 (4.7%) deteriorated, 159 (46.4%) remained unchanged, 40 (11.7%) improved, 18 (5.2%) spontaneously recovered and 30 (9.7%) were treated surgically. Of @entity0 who showed spontaneous recovery after graduation from senior high school, 16 cases (8.4%) had @entity2 and 2 (3.6%) had @entity2 . In some @entity0 , the disease type changed many years after graduation from senior high school. In particular, the appearance of stenosal lesions in the mitral or aortic valve was often delayed. The mean annual @entity1 rate for @entity0 with acquired @entity3 (age range: 6-38 years) between April 1962 and March 1983 was 0.65%. The rate peaked at the 15-17 years age range. In recent years, the fatality rate has been falling and no @entity1 are seen in younger @entity0 . In the past, the leading cause of @entity1 in juvenile @entity0 with acquired @entity3 was the recurrence of @entity4 . For the past ten years, however, no @entity1 attributable to the recurrence of @entity4 has been registered.

title: Follow up study of acquired XXXX .

answer: @entity3