abstract: BACKGROUND: Mastocytosis, characterized by pathologic accumulation of mast cells, can manifest itself in adulthood or childhood. Pediatric @entity0 usually have @entity7 ( @entity7 ) with mast cell infiltrates limited to the skin and spontaneous improvement of @entity3 after several years. However, there are some @entity0 with persistent disease resembling adulthood-onset @entity4 . OBJECTIVE: The current classification of @entity7 differentiates between 3 subforms. In clinical practice we noticed that different variants of these subforms might exist, particularly in @entity0 with childhood-onset @entity4 . Therefore, in the present study, we aimed to investigate whether specific @entity2 in @entity0 with childhood-onset @entity4 are associated with other disease parameters. METHODS: We analyzed 144 @entity0 with a disease onset of less than age 17 years using a systematic dermatologic approach. RESULTS: One hundred twenty-two @entity0 presented with @entity5 ( @entity5 ), 12 @entity0 presented with diffuse @entity7 , and 10 @entity0 presented with solitary @entity6 . @entity0 with @entity5 showed particularly heterogeneous @entity2 and were therefore grouped into 3 variants presenting either with small lesions ( @entity5 -small, @entity3 <1 cm in diameter; n  = 19), large lesions ( @entity5 -large, @entity3 >= 1 cm in diameter; n  = 89), or @entity2 ( @entity5 -other, n  = 14). @entity0 with @entity5 -large lesions, compared with those with @entity5 -small lesions, were characterized by significantly lower tryptase levels, @entity1 onset. In addition, more @entity0 with @entity5 -large lesions exhibited spontaneous regression of @entity2 . CONCLUSION: Our data show that @entity0 with @entity5 -large lesions compared with those with @entity5 -small lesions have a more favorable disease course and suggest exploring the size of @entity2 as a prognostic parameter in childhood-onset @entity5 .

title: Large maculopapular @entity2 are associated with favorable outcome in childhood-onset XXXX .

answer: @entity4


abstract: BACKGROUND: Mastocytosis, characterized by pathologic accumulation of mast cells, can manifest itself in adulthood or childhood. Pediatric @entity0 usually have @entity7 ( @entity7 ) with mast cell infiltrates limited to the skin and spontaneous improvement of @entity3 after several years. However, there are some @entity0 with persistent disease resembling adulthood-onset @entity4 . OBJECTIVE: The current classification of @entity7 differentiates between 3 subforms. In clinical practice we noticed that different variants of these subforms might exist, particularly in @entity0 with childhood-onset @entity4 . Therefore, in the present study, we aimed to investigate whether specific @entity2 in @entity0 with childhood-onset @entity4 are associated with other disease parameters. METHODS: We analyzed 144 @entity0 with a disease onset of less than age 17 years using a systematic dermatologic approach. RESULTS: One hundred twenty-two @entity0 presented with @entity5 ( @entity5 ), 12 @entity0 presented with diffuse @entity7 , and 10 @entity0 presented with solitary @entity6 . @entity0 with @entity5 showed particularly heterogeneous @entity2 and were therefore grouped into 3 variants presenting either with small lesions ( @entity5 -small, @entity3 <1 cm in diameter; n  = 19), large lesions ( @entity5 -large, @entity3 >= 1 cm in diameter; n  = 89), or @entity2 ( @entity5 -other, n  = 14). @entity0 with @entity5 -large lesions, compared with those with @entity5 -small lesions, were characterized by significantly lower tryptase levels, @entity1 onset. In addition, more @entity0 with @entity5 -large lesions exhibited spontaneous regression of @entity2 . CONCLUSION: Our data show that @entity0 with @entity5 -large lesions compared with those with @entity5 -small lesions have a more favorable disease course and suggest exploring the size of @entity2 as a prognostic parameter in childhood-onset @entity5 .

title: Large maculopapular XXXX are associated with favorable outcome in childhood-onset @entity4 .

answer: @entity2


abstract: BACKGROUND: @entity5 ( @entity5 ), such as @entity1 and @entity4 , are common reasons for @entity0 to consult primary care. @entity5 represent a significant burden not only on society, but also on health care services, through frequent physician consultations and referrals to secondary care. Research evidence suggests a positive relationship between health and consulting behavior of parents and their @entity0 , but research on whether repeated physician consultations for @entity5 in @entity0 is influenced by parental consultations for @entity5 is lacking. The aim was to measure the frequency of repeated physician consultations for @entity5 in @entity0 , and investigate whether this is influenced by maternal consultations for @entity5 . METHODS: A cohort study of @entity0 registered with primary care practices contributing to the Consultation in Primary Care Archive database. @entity0 were @entity0 -mother pairs registered between January 2007 and December 2010. The cohort comprised all @entity0 (n   =   1437) aged 2 to 16 years who consulted a physician for @entity5 in 2009. Mothers' consultations for @entity5 were measured between 2007 and 2008. Main outcome measures were repetition and frequency of consultations for @entity5 in @entity0 (consultations for @entity5 in both 2009 and 2010). RESULTS: Overall, 27% of @entity0 had repeated consultations for @entity5 . The three most common repeated consultations were for back @entity3 , @entity6 and @entity4 . Exposure to maternal consultation for @entity5 was associated with 21% increase in consultation frequency for @entity5 (adjusted incidence rate ratio 1.21; 95% CI 1.12, 1.31). After adjusting for @entity0 age and maternal age, maternal consultation for @entity5 was associated with an increased risk of repeated consultations for @entity5 in @entity0 (relative risk 1.41; 95% CI 1.16, 1.73). This association was also significant for specific @entity5 groups including @entity2 . CONCLUSIONS: Repeated consultation for @entity5 is common among @entity0 . It is important for primary care physicians and secondary care clinicians, managing @entity0 referred from primary care for @entity5 , to be aware that consultation for @entity5 in mothers is a risk factor for repeated consultations for @entity5 among @entity0 . More research is needed to uncover exactly how parental health influences health and consulting behavior of @entity0 .

title: Repeated primary care consultations for non-specific physical symptoms in XXXX in UK: a cohort study.

answer: @entity0


abstract: The RNA component of @entity0 telomerase ( @entity1 ) localizes to Cajal bodies, and it has been proposed that Cajal bodies play a role in the assembly of telomerase holoenzyme and telomerase trafficking. Here, the role of Cajal bodies was examined in @entity0 cells deficient of coilin (i.e. coilin-knockout (KO) cells), in which no Cajal bodies are detected. In coilin-KO cells, a normal level of telomerase activity is detected and interactions between core factors of holoenzyme are preserved, indicating that telomerase assembly occurs in the absence of Cajal bodies. Moreover, dispersed @entity1 aggregates and forms foci specifically during S and G2 phase in coilin-KO cells. Colocalization of these @entity1 foci with telomeres implies proper telomerase trafficking, independent of Cajal bodies. Therefore, telomerase adds similar numbers of TTAGGG repeats to telomeres in coilin-KO and controls cells. Overexpression of @entity2 -OB-fold blocks cell cycle-dependent formation of @entity1 foci and inhibits telomere extension. These findings suggest that telomerase assembly, trafficking and extension occur with normal efficiency in Cajal bodies deficient @entity0 cells. Thus, Cajal bodies, as such, are not essential in these processes, although it remains possible that non-coilin components of Cajal bodies and/or telomere binding proteins (e.g. @entity2 ) do play roles in telomerase biogenesis and telomere homeostasis.

title: XXXX cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance.

answer: @entity0


abstract: 1. The effects of two beta-adrenoreceptor blocking drugs, @entity2 and @entity4 , on plasma lipoproteins were studied in thirty-four @entity0 using a single-blind cross-over design, with a 10-day placebo washout period between drugs. 2. Compared with placebo values, neither @entity2 nor @entity4 influenced total plasma @entity1 levels, while total plasma @entity3 increased slightly. 3. Low density lipoprotein protein level remained unaltered, while high density lipoprotein (HDL) @entity1 and protein were significantly reduced by both beta-adrenoreceptor blockers. 4. The ratio of total @entity1 to HDL @entity1 was increased by both drugs. 5. The data suggest that @entity0 taking these drugs over many years may be exposing themselves to increased vascular risk, despite other anticipated benefits from such therapy.

title: The effect of @entity2 and XXXX on plasma high density lipoprotein levels in @entity0 .

answer: @entity4


abstract: 1. The effects of two beta-adrenoreceptor blocking drugs, @entity2 and @entity4 , on plasma lipoproteins were studied in thirty-four @entity0 using a single-blind cross-over design, with a 10-day placebo washout period between drugs. 2. Compared with placebo values, neither @entity2 nor @entity4 influenced total plasma @entity1 levels, while total plasma @entity3 increased slightly. 3. Low density lipoprotein protein level remained unaltered, while high density lipoprotein (HDL) @entity1 and protein were significantly reduced by both beta-adrenoreceptor blockers. 4. The ratio of total @entity1 to HDL @entity1 was increased by both drugs. 5. The data suggest that @entity0 taking these drugs over many years may be exposing themselves to increased vascular risk, despite other anticipated benefits from such therapy.

title: The effect of XXXX and @entity4 on plasma high density lipoprotein levels in @entity0 .

answer: @entity2


abstract: 1. The effects of two beta-adrenoreceptor blocking drugs, @entity2 and @entity4 , on plasma lipoproteins were studied in thirty-four @entity0 using a single-blind cross-over design, with a 10-day placebo washout period between drugs. 2. Compared with placebo values, neither @entity2 nor @entity4 influenced total plasma @entity1 levels, while total plasma @entity3 increased slightly. 3. Low density lipoprotein protein level remained unaltered, while high density lipoprotein (HDL) @entity1 and protein were significantly reduced by both beta-adrenoreceptor blockers. 4. The ratio of total @entity1 to HDL @entity1 was increased by both drugs. 5. The data suggest that @entity0 taking these drugs over many years may be exposing themselves to increased vascular risk, despite other anticipated benefits from such therapy.

title: The effect of @entity2 and @entity4 on plasma high density lipoprotein levels in XXXX .

answer: @entity0


abstract: BACKGROUND: -HF guidelines recommend screening for @entity1 ( @entity1 ) but do not identify how. The Mini-Cog is an ultra-short cognitive 'vital signs' measure that has not been studied in @entity0 hospitalized for HF. The purpose of this study was to evaluate whether @entity1 as assessed by the Mini-Cog is associated with increased readmission or mortality risk following hospitalization for HF. METHODS AND RESULTS: -We analyzed 720 consecutive @entity0 who completed the Mini-Cog as part of routine clinical care during hospitalization for HF. Our primary outcome was time between hospital discharge and first occurrence of readmission or mortality. There was a high prevalence of @entity1 as quantified by Mini-Cog performance (23% of cohort). During a mean follow up time of 6 months, 342 (48%) @entity0 were readmitted, and 24 (3%) died. Poor Mini-Cog performance was an independent predictor of composite outcome (adjusted HR 1.90, 95% @entity1 1.47-2.44, P<.0001), and was identified as most important predictor among 55 variables by Random Survival Forest analysis. Inclusion of Mini-Cog performance in risk models improved accuracy (bootstrapped c-index 0.602 vs. 0.624) and risk reclassification (category-free NRI 27%, 95% @entity1 14%-40%, P<.001). Secondary analysis of initial 30-days post-discharge showed effect modification by venue of discharge, whereby @entity0 with @entity1 discharged to a facility had longer time to outcome as compared with those discharged home. CONCLUSIONS: -Mini-Cog performance is a novel marker of post-hospitalization risk. Discharge to facility rather than home may be protective for those HF @entity0 with @entity1 . It is unknown if structured in-home support would yield similar outcomes.

title: Mini-Cog Performance: A Novel Marker of Post-Discharge Risk Among XXXX Hospitalized for Heart Failure.

answer: @entity0


abstract: The serum levels and the half life of @entity2 derived from @entity8 after administration of the latter to a total of 61 @entity0 classified in 7 groups were determined. Each of these groups was pre-treated for 15 days with the following inducers; @entity1 , @entity4 , @entity5 , @entity3 and @entity6 . The control group received saline. The @entity7 concentration in the urine prior to and after the administration of inducers and the liver weight were taken as enzyme induction indices. Results showed a positive correlation between the indices of induction and the levels of @entity2 originating from @entity8 with a significant correlation coefficient between the serum levels of @entity2 and urine @entity7 for all drugs studied. The different effect of the various drugs indicated that they could be classified into the following two groups: a) those that induced a significant increase of the levels and half life (t1/2) of @entity2 . The effect was significant in decreasing order for @entity6 (r = 0,990), @entity5 (r = 0,990) and @entity4 (r = 0,753). b) those which initially resulted in a significant increase of the levels of @entity2 and thereafter in a decrease with a significant shortening of its t1/2 too. The effect was most significant for @entity1 (r = 0,887) and less so for @entity3 (r = 0,800). Only for these two drugs was a significant and actually negative correlation observed between @entity7 and t1/2 that is: @entity1 (r = -0,967) @entity3 (r = -0,752). Results suggest an interaction of @entity8 and the above inducers.

title: Bioavailability of XXXX in @entity0 after liver enzyme induction by various inducers with or without protein binding properties.

answer: @entity8


abstract: The serum levels and the half life of @entity2 derived from @entity8 after administration of the latter to a total of 61 @entity0 classified in 7 groups were determined. Each of these groups was pre-treated for 15 days with the following inducers; @entity1 , @entity4 , @entity5 , @entity3 and @entity6 . The control group received saline. The @entity7 concentration in the urine prior to and after the administration of inducers and the liver weight were taken as enzyme induction indices. Results showed a positive correlation between the indices of induction and the levels of @entity2 originating from @entity8 with a significant correlation coefficient between the serum levels of @entity2 and urine @entity7 for all drugs studied. The different effect of the various drugs indicated that they could be classified into the following two groups: a) those that induced a significant increase of the levels and half life (t1/2) of @entity2 . The effect was significant in decreasing order for @entity6 (r = 0,990), @entity5 (r = 0,990) and @entity4 (r = 0,753). b) those which initially resulted in a significant increase of the levels of @entity2 and thereafter in a decrease with a significant shortening of its t1/2 too. The effect was most significant for @entity1 (r = 0,887) and less so for @entity3 (r = 0,800). Only for these two drugs was a significant and actually negative correlation observed between @entity7 and t1/2 that is: @entity1 (r = -0,967) @entity3 (r = -0,752). Results suggest an interaction of @entity8 and the above inducers.

title: Bioavailability of @entity8 in XXXX after liver enzyme induction by various inducers with or without protein binding properties.

answer: @entity0


abstract: UNASSIGNED: Objective: To evaluate the effect of non-pharmacological interventions to prevent anti- @entity2 medication induced @entity3 in @entity0 with a first episode of @entity1 . Methods: We searched electronic databases Medline, Embase and PsychINFO and reference lists of articles. Controlled trials evaluating the beneficial effects of non-pharmacological interventions to prevent @entity3 were eligible for inclusion. Two authors independently assessed the risk of bias of the studies and extracted data. Results: 9 studies met the inclusion criteria. Evaluation of studies was carried out separately according to the different interventions. Six studies examined the effect of behavioral interventions. Two meta-analysis were conducted and found small effects on weight management in favor of the behavioral intervention. Three studies reported the effect of nutritional counselling yielding contradictory results . Conclusions: There is currently no clear evidence which intervention is the best to prevent antipsychotic-induced @entity3 in @entity0 with first episode of @entity1 . Further trials of high methodological quality are necessary.

title: [Non-Pharmacological Interventions for the Prevention of Weight Gain in XXXX @entity0 Treated with Antipsychotic Medication].

answer: @entity1


abstract: UNASSIGNED: Objective: To evaluate the effect of non-pharmacological interventions to prevent anti- @entity2 medication induced @entity3 in @entity0 with a first episode of @entity1 . Methods: We searched electronic databases Medline, Embase and PsychINFO and reference lists of articles. Controlled trials evaluating the beneficial effects of non-pharmacological interventions to prevent @entity3 were eligible for inclusion. Two authors independently assessed the risk of bias of the studies and extracted data. Results: 9 studies met the inclusion criteria. Evaluation of studies was carried out separately according to the different interventions. Six studies examined the effect of behavioral interventions. Two meta-analysis were conducted and found small effects on weight management in favor of the behavioral intervention. Three studies reported the effect of nutritional counselling yielding contradictory results . Conclusions: There is currently no clear evidence which intervention is the best to prevent antipsychotic-induced @entity3 in @entity0 with first episode of @entity1 . Further trials of high methodological quality are necessary.

title: [Non-Pharmacological Interventions for the Prevention of Weight Gain in @entity1 XXXX Treated with Antipsychotic Medication].

answer: @entity0


abstract: The purpose of this study was to determine the expression of @entity4 and analyze its prognostic and biological significance in @entity0 ( @entity0 ). A quantitative reverse transcription PCR assay was performed to detect the expression of @entity4 in 15 pairs of @entity0 and corresponding noncancerous tissues. The expression of @entity4 was detected in another 110 @entity0 tissues and its correlations with clinicopathological factors of @entity1 were examined. Univariate and multivariate analyses were performed to analyze the prognostic significance of @entity4 expression. The effects of @entity4 expression on malignant phenotypes of @entity0 cells and its possible molecular mechanisms were further determined. @entity4 was significantly downregulated in @entity0 tissues, and low @entity4 expression was significantly correlated with lymph node @entity2 and advanced clinical stage. @entity1 with low @entity4 showed poorer overall survival than those with high @entity4 . Multivariate analyses indicated that status of @entity4 was an independent prognostic factor for @entity1 . Functional analyses showed that upregulation of @entity4 significantly inhibited growth, enhanced apoptosis, and reduced migration and invasion in @entity0 cells by targeting the protooncogene @entity3 . Therefore, @entity4 may be a potential biomarker for predicting the survival of @entity0 @entity1 and might be a molecular target for treatment of @entity1 BCs.

title: Prognostic and Biological Significance of MicroRNA-127 Expression in @entity1 XXXX .

answer: @entity0


abstract: The purpose of this study was to determine the expression of @entity4 and analyze its prognostic and biological significance in @entity0 ( @entity0 ). A quantitative reverse transcription PCR assay was performed to detect the expression of @entity4 in 15 pairs of @entity0 and corresponding noncancerous tissues. The expression of @entity4 was detected in another 110 @entity0 tissues and its correlations with clinicopathological factors of @entity1 were examined. Univariate and multivariate analyses were performed to analyze the prognostic significance of @entity4 expression. The effects of @entity4 expression on malignant phenotypes of @entity0 cells and its possible molecular mechanisms were further determined. @entity4 was significantly downregulated in @entity0 tissues, and low @entity4 expression was significantly correlated with lymph node @entity2 and advanced clinical stage. @entity1 with low @entity4 showed poorer overall survival than those with high @entity4 . Multivariate analyses indicated that status of @entity4 was an independent prognostic factor for @entity1 . Functional analyses showed that upregulation of @entity4 significantly inhibited growth, enhanced apoptosis, and reduced migration and invasion in @entity0 cells by targeting the protooncogene @entity3 . Therefore, @entity4 may be a potential biomarker for predicting the survival of @entity0 @entity1 and might be a molecular target for treatment of @entity1 BCs.

title: Prognostic and Biological Significance of MicroRNA-127 Expression in XXXX @entity0 .

answer: @entity1


abstract: Objectives. To explore the association between meditation and health related quality of life (HRQOL), @entity2 , @entity3 , disability level, relapse rates, and disease activity in a large international sample of @entity0 with @entity1 ( @entity1 ). Methods. @entity0 were invited to take part in an online survey and answer questions relating to HRQOL, @entity2 , @entity3 , disability, relapse rates, and their involvement in meditation practices. Results. Statistically and potentially clinically significant differences between those who meditated once a week or more and @entity0 who never meditated were present for mean mental health composite (MHC) scores, cognitive function scale, and health perception scale. The MHC results remained statistically significant on multivariate regression modelling when covariates were accounted for. Physical health composite (PHC) scores were higher in those that meditated; however, the differences were probably not clinically significant. Among those who meditated, fewer screened positive for @entity2 , but there was no relationship with @entity3 or relapse rate. Those with worsened disability levels were more likely to meditate. Discussion. The study reveals a significant association between meditation, lower risk of @entity2 , and improved HRQOL in @entity0 with @entity1 .

title: Can meditation influence quality of life, XXXX , and disease outcome in @entity1 ? Findings from a large international web-based study.

answer: @entity2


abstract: Objectives. To explore the association between meditation and health related quality of life (HRQOL), @entity2 , @entity3 , disability level, relapse rates, and disease activity in a large international sample of @entity0 with @entity1 ( @entity1 ). Methods. @entity0 were invited to take part in an online survey and answer questions relating to HRQOL, @entity2 , @entity3 , disability, relapse rates, and their involvement in meditation practices. Results. Statistically and potentially clinically significant differences between those who meditated once a week or more and @entity0 who never meditated were present for mean mental health composite (MHC) scores, cognitive function scale, and health perception scale. The MHC results remained statistically significant on multivariate regression modelling when covariates were accounted for. Physical health composite (PHC) scores were higher in those that meditated; however, the differences were probably not clinically significant. Among those who meditated, fewer screened positive for @entity2 , but there was no relationship with @entity3 or relapse rate. Those with worsened disability levels were more likely to meditate. Discussion. The study reveals a significant association between meditation, lower risk of @entity2 , and improved HRQOL in @entity0 with @entity1 .

title: Can meditation influence quality of life, @entity2 , and disease outcome in XXXX ? Findings from a large international web-based study.

answer: @entity1


abstract: BACKGROUND: Statins are shown effective by some studies in preventing @entity1 ( @entity1 ). We evaluated the effectiveness of @entity3 in the prevention of @entity1 in computed tomography angiography (CTA) candidates. METHODS: This study was conducted on @entity0 referring for elective CTA with normal renal function. @entity0 received @entity3 (80 mg/day) or placebo from 24 h before to 48 h after administration of the contrast material. Serum @entity2 was measured before and 48 h after contrast material injection. @entity1 was defined as an increase in serum @entity2 level of >=  0.5 mg/dl or >=  25% of the baseline @entity2 . RESULTS: A total of 236 @entity0 completed the study; 115 @entity3 , 121 placebo, mean age = 58.40    9.80 year, 68.6% male. Serum @entity2 increased after contrast material injection in both the @entity3 (1.00    0.16-1.02    0.15 mg/dl, P = 0.017) and placebo groups (1.03    0.17-1.08    0.18 mg/dl, P < 0.001). Controlling for age, gender, comorbidities, drug history, and baseline serum @entity2 level, @entity0 who received @entity3 experienced less increase in serum @entity2 after contrast material injection (beta = 0.127, P = 0.034). However, there was no difference between the @entity3 and placebo groups in the incidence of @entity1 (4.3 vs. 5.0%, P = 0.535). CONCLUSION: In @entity0 undergoing CTA, a short-term treatment with high dose @entity3 is effective in preventing contrast-induced @entity1 , in terms of less increase in serum @entity2 level after contrast material injection. Further trials including larger sample of @entity0 and longer follow-ups are warranted.

title: Short term high dose @entity3 for the prevention of XXXX in @entity0 undergoing computed tomography angiography.

answer: @entity1


abstract: BACKGROUND: Statins are shown effective by some studies in preventing @entity1 ( @entity1 ). We evaluated the effectiveness of @entity3 in the prevention of @entity1 in computed tomography angiography (CTA) candidates. METHODS: This study was conducted on @entity0 referring for elective CTA with normal renal function. @entity0 received @entity3 (80 mg/day) or placebo from 24 h before to 48 h after administration of the contrast material. Serum @entity2 was measured before and 48 h after contrast material injection. @entity1 was defined as an increase in serum @entity2 level of >=  0.5 mg/dl or >=  25% of the baseline @entity2 . RESULTS: A total of 236 @entity0 completed the study; 115 @entity3 , 121 placebo, mean age = 58.40    9.80 year, 68.6% male. Serum @entity2 increased after contrast material injection in both the @entity3 (1.00    0.16-1.02    0.15 mg/dl, P = 0.017) and placebo groups (1.03    0.17-1.08    0.18 mg/dl, P < 0.001). Controlling for age, gender, comorbidities, drug history, and baseline serum @entity2 level, @entity0 who received @entity3 experienced less increase in serum @entity2 after contrast material injection (beta = 0.127, P = 0.034). However, there was no difference between the @entity3 and placebo groups in the incidence of @entity1 (4.3 vs. 5.0%, P = 0.535). CONCLUSION: In @entity0 undergoing CTA, a short-term treatment with high dose @entity3 is effective in preventing contrast-induced @entity1 , in terms of less increase in serum @entity2 level after contrast material injection. Further trials including larger sample of @entity0 and longer follow-ups are warranted.

title: Short term high dose XXXX for the prevention of @entity1 in @entity0 undergoing computed tomography angiography.

answer: @entity3


abstract: BACKGROUND: Statins are shown effective by some studies in preventing @entity1 ( @entity1 ). We evaluated the effectiveness of @entity3 in the prevention of @entity1 in computed tomography angiography (CTA) candidates. METHODS: This study was conducted on @entity0 referring for elective CTA with normal renal function. @entity0 received @entity3 (80 mg/day) or placebo from 24 h before to 48 h after administration of the contrast material. Serum @entity2 was measured before and 48 h after contrast material injection. @entity1 was defined as an increase in serum @entity2 level of >=  0.5 mg/dl or >=  25% of the baseline @entity2 . RESULTS: A total of 236 @entity0 completed the study; 115 @entity3 , 121 placebo, mean age = 58.40    9.80 year, 68.6% male. Serum @entity2 increased after contrast material injection in both the @entity3 (1.00    0.16-1.02    0.15 mg/dl, P = 0.017) and placebo groups (1.03    0.17-1.08    0.18 mg/dl, P < 0.001). Controlling for age, gender, comorbidities, drug history, and baseline serum @entity2 level, @entity0 who received @entity3 experienced less increase in serum @entity2 after contrast material injection (beta = 0.127, P = 0.034). However, there was no difference between the @entity3 and placebo groups in the incidence of @entity1 (4.3 vs. 5.0%, P = 0.535). CONCLUSION: In @entity0 undergoing CTA, a short-term treatment with high dose @entity3 is effective in preventing contrast-induced @entity1 , in terms of less increase in serum @entity2 level after contrast material injection. Further trials including larger sample of @entity0 and longer follow-ups are warranted.

title: Short term high dose @entity3 for the prevention of @entity1 in XXXX undergoing computed tomography angiography.

answer: @entity0


abstract: @entity5 in multiple colonscopic biopsy specimens may held identify those @entity0 with chronic @entity2 (CUC) at highest risk for developing @entity3 . This retrospective analysis of 75 @entity0 with longstanding CUC studied by colonoscopy and biopsy disclosed 11 @entity0 with @entity1 . Four of these @entity1 were detected by surveillance colonoscopy and seven were detected by diagnostic colonoscopy. There was a high correlation between the presence of @entity4 and @entity1 in the @entity0 . @entity1 was found in five of seven @entity0 who underwent operation after colonoscopic biopsies showed severe @entity4 . No @entity1 were found at operation in 15 @entity0 whose colonoscopic biopsy specimens were free of @entity4 . @entity4 can be consistently identified. A reviewing pathologist agreed with the initial biopsy diagnosis in 59 of 64 cases (92%) and with the colectomy diagnosis in 18 of 21 (86%). Colonscopy with multiple biopsy specimens is a valuable surveillance technic. @entity0 without @entity4 on biopsy should have continued surveillance.

title: Endoscopic surveillance for @entity1 in chronic XXXX .

answer: @entity2


abstract: @entity5 in multiple colonscopic biopsy specimens may held identify those @entity0 with chronic @entity2 (CUC) at highest risk for developing @entity3 . This retrospective analysis of 75 @entity0 with longstanding CUC studied by colonoscopy and biopsy disclosed 11 @entity0 with @entity1 . Four of these @entity1 were detected by surveillance colonoscopy and seven were detected by diagnostic colonoscopy. There was a high correlation between the presence of @entity4 and @entity1 in the @entity0 . @entity1 was found in five of seven @entity0 who underwent operation after colonoscopic biopsies showed severe @entity4 . No @entity1 were found at operation in 15 @entity0 whose colonoscopic biopsy specimens were free of @entity4 . @entity4 can be consistently identified. A reviewing pathologist agreed with the initial biopsy diagnosis in 59 of 64 cases (92%) and with the colectomy diagnosis in 18 of 21 (86%). Colonscopy with multiple biopsy specimens is a valuable surveillance technic. @entity0 without @entity4 on biopsy should have continued surveillance.

title: Endoscopic surveillance for XXXX in chronic @entity2 .

answer: @entity1


abstract: BACKGROUND: Appropriate chemotherapy dosing for @entity2 @entity0 with @entity1 is a significant challenge because limiting chemotherapy doses in these @entity0 may negatively influence outcome. There is a paucity of information addressing high-dose chemotherapy in @entity2 @entity0 undergoing hematopoietic stem cell transplantation (HSCT). METHODS: The Acute @entity3 Working Party of the European Society for Blood and Marrow Transplantation (EBMT) designed an electronic survey to assess current practice of dose adjustment of chemotherapy in @entity2 @entity0 undergoing HSCT. RESULTS: A total of 56 EBMT centers from 27 countries responded to the online survey. Overall, 45 centers declared that they routinely adjust chemotherapy doses for @entity2 @entity0 (80.5%), and only 11 (19.5%) declared they do not adjust dose. Among the former group, most used body mass index as the parameter for defining @entity2 (28 centers, 62%). The method for determining the weight for chemotherapy calculation was actual body weight (ABW) in 16 centers, ideal body weight (IBW) in 10 centers, IBW plus 25% of the difference between IBW and ABW in 16 centers, and other methods for the rest. Among centers that used dose adjustment, 44% also capped the dose at 2 m(2) for a chemotherapy dose based on body surface area (BSA), whereas 56% did not cap. Interestingly, most of the centers (9 of 11) that did not adjust dose for weight also did not cap the BSA at 2 m(2). CONCLUSION: This EBMT survey revealed large diversity among transplant centers regarding dose-adjustment practice for high-dose conditioning chemotherapy. Our next step is to analyze outcomes of transplantation according to dose-adjustment practice and, subsequently, to formulate a methodology for future prospective studies.

title: Chemotherapy Dose Adjustment for Obese @entity0 Undergoing Hematopoietic Stem Cell Transplantation: A Survey on Behalf of the Acute XXXX Working Party of the European Society for Blood and Marrow Transplantation.

answer: @entity3


abstract: BACKGROUND: Appropriate chemotherapy dosing for @entity2 @entity0 with @entity1 is a significant challenge because limiting chemotherapy doses in these @entity0 may negatively influence outcome. There is a paucity of information addressing high-dose chemotherapy in @entity2 @entity0 undergoing hematopoietic stem cell transplantation (HSCT). METHODS: The Acute @entity3 Working Party of the European Society for Blood and Marrow Transplantation (EBMT) designed an electronic survey to assess current practice of dose adjustment of chemotherapy in @entity2 @entity0 undergoing HSCT. RESULTS: A total of 56 EBMT centers from 27 countries responded to the online survey. Overall, 45 centers declared that they routinely adjust chemotherapy doses for @entity2 @entity0 (80.5%), and only 11 (19.5%) declared they do not adjust dose. Among the former group, most used body mass index as the parameter for defining @entity2 (28 centers, 62%). The method for determining the weight for chemotherapy calculation was actual body weight (ABW) in 16 centers, ideal body weight (IBW) in 10 centers, IBW plus 25% of the difference between IBW and ABW in 16 centers, and other methods for the rest. Among centers that used dose adjustment, 44% also capped the dose at 2 m(2) for a chemotherapy dose based on body surface area (BSA), whereas 56% did not cap. Interestingly, most of the centers (9 of 11) that did not adjust dose for weight also did not cap the BSA at 2 m(2). CONCLUSION: This EBMT survey revealed large diversity among transplant centers regarding dose-adjustment practice for high-dose conditioning chemotherapy. Our next step is to analyze outcomes of transplantation according to dose-adjustment practice and, subsequently, to formulate a methodology for future prospective studies.

title: Chemotherapy Dose Adjustment for Obese XXXX Undergoing Hematopoietic Stem Cell Transplantation: A Survey on Behalf of the Acute @entity3 Working Party of the European Society for Blood and Marrow Transplantation.

answer: @entity0


abstract: This paper evaluates the effect of introducing two new workforce roles under a pilot program conducted in Victoria, Australia. The trial took place at a regional hospital's @entity1 ( @entity1 ) between 1 July 2008 and 30 June 2009. The evaluation is based on three outcome measures: waiting time (in minutes) at @entity1 before treatment; proportion of presentations with waiting time on target; and length of stay (in days), for @entity1 presentations that led to in- @entity0 admissions. The technique of difference-in-differences analysis is used. A total of 142,980 @entity0 records from the pilot hospital and three comparison hospitals were extracted from the Victorian Emergency Minimum Dataset (VEMD). Further, 21,925 records of @entity0 whose @entity1 presentations led to in- @entity0 admissions were extracted from the Victorian Admitted Episodes Dataset (VAED). The evaluation finds the piloted roles have lowered waiting time and raised the proportion of on-target presentations. These effects were found to be the strongest for less urgent triage categories. However, the evidence on in- @entity0 length of stay was mixed. The results provide positive evidence that new workforce roles can be effective in improving the efficiency of emergency care delivery.

title: Do new workforce roles reduce waiting times in XXXX ? A difference-in-difference evaluation using hospital administrative data.

answer: @entity1


abstract: UNASSIGNED: A variety of imaging, neuropsychological, and genetic biomarkers have been suggested as potential biomarkers for the identification of @entity1 ( @entity1 ) in @entity0 who later develop @entity2 ( @entity2 ). Here, we systematically evaluated the most promising combinations of these biomarkers regarding discrimination between stable and converter @entity1 and reflection of disease staging. @entity2 Neuroimaging Initiative data of @entity2 (n=144), controls (n=112), stable (n=265) and converter (n=177) @entity1 , for which @entity4 status, neuropsychological evaluation, and structural, @entity3 , and amyloid imaging were available, were included in this study. @entity5  ve Bayes classifiers were built on @entity2 and controls data for all possible combinations of these biomarkers, with and without stratification by amyloid status. All classifiers were then applied to the @entity1 cohorts. We obtained an accuracy of 76% for discrimination between converter and stable @entity1 with @entity3 positron emission tomography as a single biomarker. This accuracy increased to about 87% when including further imaging modalities and genetic information. We also identified several biomarker combinations as strong predictors of time to conversion. Use of amyloid validated training data resulted in increased sensitivities and decreased specificities for differentiation between stable and converter @entity1 when amyloid was included as a biomarker but not for other classifier combinations. Our results indicate that fully independent classifiers built only on @entity2 and controls data and combining imaging, genetic, and/or neuropsychological biomarkers can more reliably discriminate between stable and converter @entity1 than single modality classifiers. Several biomarker combinations are identified as strongly predictive for the time to conversion to @entity2 .

title: Accurate Prediction of Conversion to XXXX using Imaging, Genetic, and Neuropsychological Biomarkers.

answer: @entity2


abstract: The molecular dynamics of solutions of di-propylene glycol methylether (2PGME) and @entity0 (or @entity1 ) confined in 28    pores of @entity5 have been studied by quasielastic neutron scattering and differential scanning calorimetry over the concentration range 0-90 wt.% water. This system is of particular interest due to its pronounced non-monotonic concentration dependent dynamics of 2PGME in the corresponding bulk system, showing the important role of @entity4 bonding for the dynamics. In this study we have elucidated how this non-monotonic concentration dependence is affected by the confined geometry. The results show that this behaviour is maintained in the confinement, but the slowest diffusive dynamics of 2PGME is now observed at a considerably higher water concentration; at 75 wt.% water in @entity5 compared to 30 wt.% water in the corresponding bulk system. This difference can be explained by an improper mixing of the two confined liquids. The results suggest that water up to a concentration of about 20 wt.% is used to hydrate the hydrophilic @entity3 surface groups of the @entity2 pores, and that it is only at higher water contents the water becomes partly mixed with 2PGME. Hence, due to this partial micro-phase separation of the two liquids larger, and thereby slower relaxing, structural entities of @entity4 bonded water and 2PGME molecules can only be formed at higher water contents than in the bulk system. However, the Q-dependence is unchanged with confinement, showing that the nature of the molecular motions is preserved. Thus, there is no indication of localization of the dynamics at length scales of less than 20   . The dynamics of both water and 2PGME is strongly dominated by translational diffusion at a temperature of 280 K.

title: Anomalous dynamics of aqueous solutions of di-propylene glycol methylether confined in XXXX by quasielastic neutron scattering.

answer: @entity5


abstract: Neuropsychological assessment tests have an important role in early detection of @entity2 . Therefore, we designed and implemented a test battery for mobile devices that can be used for @entity1 ( @entity1 ). This battery consists of 33 questions from 14 type of tests for the assessment of 8 different cognitive functions: Arithmetic, orientation, abstraction, attention, memory, language, visual, and executive functions. This test battery is implemented as an application for mobile devices that operates on Android OS. In order to validate the effectiveness of the neuropsychological test battery, it was applied on a group of 23 elderly @entity0 . Within this group, 9 (of age 81.78  4.77) were healthy and 14 (of age 72.55  9.95) were already diagnosed with @entity2 . The education level of the control group (healthy) and @entity2 group were comparable as they spent 13.66  5.07 and 13.71  4.14 years at school respectively. For comparison, a validated paper-and-pencil test (Montreal Cognitive Test - @entity3 ) was applied along with the proposed @entity1 battery. The proposed test was able to differentiate the individuals in the control and @entity2 groups for executive, visual, memory, attention, orientation functions with statistical significance (p<0.05). Results of the remaining functions; language, abstraction, and arithmetic were statistically insignificant (p>0.05). The results of @entity1 and @entity3 were compared, and the scores of individuals from these tests were correlated (r(2)=0.57).

title: A mobile application for cognitive screening of XXXX .

answer: @entity2


abstract: OBJECTIVES: Stereotactic body radiotherapy (SBRT) is being increasingly used for the treatment of @entity0 with @entity1 or lung @entity2 who are medically unfit to undergo resection. In order to improve accuracy and confidence in targeting @entity3 , many centers rely on fiducial implantation. We evaluated the migration of a novel fiducial marker specifically designed for lung tissue implanted via electromagnetic navigation bronchoscopy (ENB). METHODS: We retrospectively quantified the individual and group migrations of SuperLock @entity4 coil fiducials for 15 @entity0 receiving lung stereotactic body radiotherapy (SBRT), in order to evaluate the reliability of using these fiducials as a target surrogate for cases where @entity3 cannot be clearly delineated on cone beam CTs (CBCTs). For each fraction, we compared the individual and group migrations of the fiducials between the planning CT and the acquired CBCT. The group migration was defined as the distance between the centroids of the fiducial group and GTV. RESULTS: A total of 16 lung targets were included in our study for these 15 @entity0 (one @entity0 with two targets). Of 55 fiducials placed, we observed a 100% retention rate. The mean individual migration was 1.87 mm (range, 0.63-5.25 mm) with a standard deviation of 1.26 mm. The mean group migration was 1.94 mm (range, 0.03-6.19 mm) with a standard deviation of 1.45 mm. Overall, there was minimal change in the relative locations of the markers with respect to each other, as well as to the target. CONCLUSIONS: We found that the SuperLock @entity4 coil fiducial marker positions are stable throughout the radiation treatment, and can be used as a reliable surrogate to target, and to avoid geometric misses during gated treatments.

title: Minimal Inter-Fractional Fiducial Migration during Image-Guided Lung Stereotactic Body Radiotherapy Using SuperLock XXXX Coil Fiducial Markers.

answer: @entity4


abstract: An @entity7 ( @entity7 ) mutation in the last canonical @entity0 -binding epidermal growth factor (cbEGF) domain of @entity5 ( @entity5 ) causes the rare @entity2 , @entity6 ( @entity6 ). In cell culture studies, this mutation leads to inefficient @entity5 secretion and higher intracellular steady state levels, likely due to @entity5 @entity3 bonding and/or protein folding problems. However, how the @entity7 mutation actually causes @entity6 is still largely unknown. Herein we tested whether the introduction of analogous, 'pseudo-pathogenic' @entity4 mutations immediately after the bn @entity1 (bn+1) in other cbEGF domains also caused protein folding/secretion challenges. We found that introduction of @entity4 mutations into each of the four other @entity5 canonical cbEGF domains caused a significant reduction in protein secretion ranging from 2.7 to 56% of wild-type (WT) @entity5 levels. Surprisingly, an @entity9 mutation in the first canonical cbEGF domain of @entity5 yielded the highest amount of secretion among the @entity5 @entity4 mutants, and its secretion defect could be rescued to near WT levels (95%) after growth temperature reduction. Interestingly, when similarly positioned @entity4 mutations were introduced into any of the canonical cbEGF domains of the highly homologous protein, @entity8 ( @entity8 ), there was no effect on secretion. In an attempt to make @entity5 tolerant of @entity4 residues (like @entity8 ), we genetically engineered @entity5 to have a higher sequence homology with @entity8 by deleting three insert regions present in @entity5 , but not @entity8 . However, deletion of one or more of these regions did not have a beneficial effect on @entity7 @entity5 secretion. Overall, these results demonstrate that the introduction of @entity4 residues at the bn+1 position does not universally disrupt cbEGF domain folding and secretion, but that their effect is context dependent, and in this case, uniquely disrupt the folding of canonical cbEGF domains of @entity5 , but not @entity8 .

title: Differential tolerance of 'pseudo-pathogenic' XXXX residues in @entity0 -binding EGF domains of short fibulin proteins.

answer: @entity4


abstract: An @entity7 ( @entity7 ) mutation in the last canonical @entity0 -binding epidermal growth factor (cbEGF) domain of @entity5 ( @entity5 ) causes the rare @entity2 , @entity6 ( @entity6 ). In cell culture studies, this mutation leads to inefficient @entity5 secretion and higher intracellular steady state levels, likely due to @entity5 @entity3 bonding and/or protein folding problems. However, how the @entity7 mutation actually causes @entity6 is still largely unknown. Herein we tested whether the introduction of analogous, 'pseudo-pathogenic' @entity4 mutations immediately after the bn @entity1 (bn+1) in other cbEGF domains also caused protein folding/secretion challenges. We found that introduction of @entity4 mutations into each of the four other @entity5 canonical cbEGF domains caused a significant reduction in protein secretion ranging from 2.7 to 56% of wild-type (WT) @entity5 levels. Surprisingly, an @entity9 mutation in the first canonical cbEGF domain of @entity5 yielded the highest amount of secretion among the @entity5 @entity4 mutants, and its secretion defect could be rescued to near WT levels (95%) after growth temperature reduction. Interestingly, when similarly positioned @entity4 mutations were introduced into any of the canonical cbEGF domains of the highly homologous protein, @entity8 ( @entity8 ), there was no effect on secretion. In an attempt to make @entity5 tolerant of @entity4 residues (like @entity8 ), we genetically engineered @entity5 to have a higher sequence homology with @entity8 by deleting three insert regions present in @entity5 , but not @entity8 . However, deletion of one or more of these regions did not have a beneficial effect on @entity7 @entity5 secretion. Overall, these results demonstrate that the introduction of @entity4 residues at the bn+1 position does not universally disrupt cbEGF domain folding and secretion, but that their effect is context dependent, and in this case, uniquely disrupt the folding of canonical cbEGF domains of @entity5 , but not @entity8 .

title: Differential tolerance of 'pseudo-pathogenic' @entity4 residues in XXXX -binding EGF domains of short fibulin proteins.

answer: @entity0


abstract: Chromatin heteroaggregates comprising nucleosomal arrays, DNA, histone and non-histone host cell proteins contributed 28% of the host contaminant mass in an IgG cell culture harvest. A subset comprising soluble particles of 50-400nm was retained through its histone component by an electronegative multimodal chromatography adsorbent. Accumulated heteroaggregates hindered pore access and @entity0 IgG capacity by 69% compared with capacity determined with purified IgG. Heteroaggregate retention persisted in 2M @entity2 but some associations within them were dissociated. This manifested during IgG elution as contaminant leaching from the retained heteroaggregate mass, which contributed more than 95% of the contaminants in the IgG. Retained heteroaggregates also interfered with pore egress of eluted IgG, increasing peak width    3-fold. IgG recovery was 80%. Remaining heteroaggregates were removed with 1M @entity5 . @entity3 with a hybrid @entity1 -solid phase clarification method reduced DNA more than 3 logs, histones beneath the level of detectability, and non-histone proteins by 90% while conserving 90% of the IgG. Non-lipid-enveloped virus was reduced by 5 logs and lipid-enveloped virus by 9 logs. IgG capacity on the multimodal adsorbent was 94mg/mL, compared with 95mg/mL when loaded with protein A-purified IgG. Non-histone host protein reduction increased to 98%. IgG eluted in a sharp concentrated peak and step recovery was >95%. Residual @entity4 did not bind the adsorbent and were mostly eliminated during sample loading. A single polishing step with an electropositive multimodal adsorbent reduced non-histone host proteins to <100ppm, DNA to <10ppb, and aggregates to <0.05%. IgG recovery across the entire process was >80%. These results qualify electronegative multimodal adsorbents as an IgG capture option, but more importantly reveal chromatin heteroaggregate content as a keystone process variable at all stages of purification process development.

title: Chromatin-mediated XXXX of fractionation performance on electronegative multimodal chromatography media, its prevention, and ramifications for purification of immunoglobulin G.

answer: @entity0


abstract: UNASSIGNED: Robustness is a complex trait difficult to characterize and phenotype. In the present study, two features of robustness in @entity3 were investigated: sensitivity and resilience to an acute stressor. For that purpose, @entity0 consumption, @entity2 release, group dispersion and group activity of two isogenic lines of juvenile @entity3 were followed before and after an environmental challenge. The effect of a 4h confinement protocol (~140kg/m(3)), which is generally considered as a highly stressful challenge, was investigated. Temporal patterns produced by this experiment were analyzed using multivariate statistics on curve characteristics to describe physiological and behavioral adaptive systems for each isogenic line. The two isogenic lines were found to be highly divergent in their corticosteroid reactivity. However, no correlation between physiological and behavioral sensitivity or resilience was observed. Furthermore, the multivariate analysis results indicated two separate and independent fish group coping strategies, i.e. by favoring either behavioral or physiological responses. In addition, considerable intra-line variabilities were observed, suggesting the importance of micro-environment effects on perturbation sensitivities. In this context, @entity2 release rate variability was found to be related to the pre-stress social environment, with a strong correlation between pre-stress @entity1 and @entity2 release rate amplitude. Overall, this approach allowed us to extract important characteristics from dynamic data in physiology and behavior to describe components of robustness in two isogenic lines of @entity3 .

title: A multivariate analysis using physiology and behavior to characterize robustness in two isogenic lines of XXXX exposed to a confinement stress.

answer: @entity3


abstract: Insufficient bone anchoring is a major limitation of artificial substitutes for connective osteoarticular tissues. The use of coatings containing osseoconductive ceramic particles is one of the actively explored strategies to improve osseointegration and strengthen the bone-implant interface for general tissue engineering. Our hypothesis is that @entity0 (HA) particles can be coated robustly on specific assemblies of @entity1 hydrogel fibers for the potential anchoring of ligament replacements. A simple dip-coating method is described to produce composite coatings made of microscopic @entity0 (HA) particles dispersed in a @entity2 ( @entity1 ) matrix. The materials are compatible with the requirements for implant Good Manufacturing Practices. They are applied to coat bundles of @entity1 hydrogel fibers used for the development of ligament implants. By means of optical and electronic microscopy, we show that the coating thickness and surface state can be adjusted by varying the composition of the dipping solution. Quantitative analysis based on backscattered electron microscopy show that the exposure of HA at the coating surface can be tuned from 0 to over 55% by decreasing the weight ratio of @entity1 over HA from 0.4 to 0.1. Abrasion experiments simulating bone-implant contact illustrate how the @entity3 and wear resistance increase by increasing the content of @entity1 relative to HA. Using pullout experiments, we find that these coatings adhere well to the fiber bundles and detach by propagation of a crack inside the coating. These results provide a guide to select coated implants for anchoring artificial ligaments.

title: @entity2 hydrogel coatings with tunable surface exposure of XXXX .

answer: @entity0


abstract: Insufficient bone anchoring is a major limitation of artificial substitutes for connective osteoarticular tissues. The use of coatings containing osseoconductive ceramic particles is one of the actively explored strategies to improve osseointegration and strengthen the bone-implant interface for general tissue engineering. Our hypothesis is that @entity0 (HA) particles can be coated robustly on specific assemblies of @entity1 hydrogel fibers for the potential anchoring of ligament replacements. A simple dip-coating method is described to produce composite coatings made of microscopic @entity0 (HA) particles dispersed in a @entity2 ( @entity1 ) matrix. The materials are compatible with the requirements for implant Good Manufacturing Practices. They are applied to coat bundles of @entity1 hydrogel fibers used for the development of ligament implants. By means of optical and electronic microscopy, we show that the coating thickness and surface state can be adjusted by varying the composition of the dipping solution. Quantitative analysis based on backscattered electron microscopy show that the exposure of HA at the coating surface can be tuned from 0 to over 55% by decreasing the weight ratio of @entity1 over HA from 0.4 to 0.1. Abrasion experiments simulating bone-implant contact illustrate how the @entity3 and wear resistance increase by increasing the content of @entity1 relative to HA. Using pullout experiments, we find that these coatings adhere well to the fiber bundles and detach by propagation of a crack inside the coating. These results provide a guide to select coated implants for anchoring artificial ligaments.

title: XXXX hydrogel coatings with tunable surface exposure of @entity0 .

answer: @entity2


abstract: BACKGROUND: @entity6 has been approved for the treatment of lower-risk @entity4 ( @entity4 ) with 5q deletion (del(5q)). We present for the first time a retrospective analysis of low-risk @entity4 with isolated del5q treated with @entity6 , outside the clinical trials. METHODS: 36 red blood cell (RBC) transfusion-dependent @entity0 have been included in the study. @entity0 received @entity6 10  mg/day on days 1-21 of 28-day cycles. RESULTS: 91.7  % of @entity0 responded to @entity6 treatment: 72.2  % achieved erythroid response, 19.4  % achieved minor erythroid response and 8.4  % of @entity0 did not respond to treatment. Response depended on number of previous treatment lines (p   =   0.0101), International Prognostic System Score (IPSS; p   =   0.0067) and RBC transfusion frequency (p   =   0.0139). Median duration of response was 16  months (range 6-60 months). Treatment was well tolerated. We observed hematological @entity1 (grade 3 and 4): @entity3 in 16 (44.4  %) @entity0 and @entity2 in 9 (25  %) @entity0 . Two @entity0 (5.5  %) progressed to high-risk @entity4 and two subsequent progressed to @entity5 . A Kaplan-Meier estimate for overall survival at 5  years in the study group was 79.0        8.8  %. CONCLUSIONS: @entity6 in this group of @entity0 was beneficial for the treatment of RBC transfusion-dependency with well-known safety profile.

title: Polish experience of @entity6 in the treatment of lower risk XXXX with isolated del(5q).

answer: @entity4


abstract: BACKGROUND: @entity6 has been approved for the treatment of lower-risk @entity4 ( @entity4 ) with 5q deletion (del(5q)). We present for the first time a retrospective analysis of low-risk @entity4 with isolated del5q treated with @entity6 , outside the clinical trials. METHODS: 36 red blood cell (RBC) transfusion-dependent @entity0 have been included in the study. @entity0 received @entity6 10  mg/day on days 1-21 of 28-day cycles. RESULTS: 91.7  % of @entity0 responded to @entity6 treatment: 72.2  % achieved erythroid response, 19.4  % achieved minor erythroid response and 8.4  % of @entity0 did not respond to treatment. Response depended on number of previous treatment lines (p   =   0.0101), International Prognostic System Score (IPSS; p   =   0.0067) and RBC transfusion frequency (p   =   0.0139). Median duration of response was 16  months (range 6-60 months). Treatment was well tolerated. We observed hematological @entity1 (grade 3 and 4): @entity3 in 16 (44.4  %) @entity0 and @entity2 in 9 (25  %) @entity0 . Two @entity0 (5.5  %) progressed to high-risk @entity4 and two subsequent progressed to @entity5 . A Kaplan-Meier estimate for overall survival at 5  years in the study group was 79.0        8.8  %. CONCLUSIONS: @entity6 in this group of @entity0 was beneficial for the treatment of RBC transfusion-dependency with well-known safety profile.

title: Polish experience of XXXX in the treatment of lower risk @entity4 with isolated del(5q).

answer: @entity6


abstract: AIM: This study evaluates the effects of three surgical procedures in the treatment of pronation deformities of the forearm in @entity2 @entity0 ; namely the transposition of pronator teres to extensor carpi radialis brevis muscle; and rerouting of the pronator teres muscle with or without pronator quadratus @entity1 . METHODS: Sixty-one @entity0 , 48 male/13 female, with a mean age of 17 years (5-41 years) were treated between 1971 and 2011. Pronator teres transposition was performed in 10, pronator rerouting in 35, and pronator rereouting with pronator quadratus myotomy in 16 @entity0 . Ranges of motion, and assessments using the Quick Dash, Mayo Scoring, and Functional Classification system of @entity3 , were made before and after surgery. Mean follow-up was 17.5 years (3-41 years). RESULTS: All three procedures led to significantly improved ranges of motion and upper limb function, with good/excellent results in 80 % of @entity0 . Mean active supination improved from 10    (0-60   ) to 85    (30-90   ) (p   <   0.001). There were significant improvements in Functional Classification system for the @entity3 scores (p   <   0.003), Mean Quick Dash Scores improved from 58.41 (38.63-79.54) to 44.59 (27.27-68.18), and mean MEPS improved from 68 (30-85) to 84 (60-100) following surgery. All three techniques had statistically improved MEPS following surgery (p   <   0.001); only the pronator teres muscle rerouting with pronator quadratus myotomy showed an improved Functional Classification system for the @entity3 score (p   <   0.05); and only the pronator teres rerouting procedure showed an improved Quick Dash score (p   <   0.05). There were no statistically significant differences in outcomes between different ages groups, and no significant differences between isolated pronator teres muscle rerouting were compared with those undergoing simultaneous treatment of @entity4 (p   >   0.05). CONCLUSION: Surgery is very effective in the management of pronation deformities of the forearm in @entity0 with @entity2 . Isolated pronator teres rerouting is probably the most effective and simple technique. Adjunctive pronator quadratus myotomy does not lead to an improvement in the results and requires an additional surgical approach. There should be no age restriction to surgery, as all age groups appear to benefit from similar improvements in range of motion and upper limb function.

title: The results of surgical treatment for pronation deformities of the forearm in XXXX after a mean follow-up of 17.5  years.

answer: @entity2


abstract: UNASSIGNED: @entity2 is classified as the 3rd leading cause of @entity1 worldwide and is deemed to be a preventable cause of @entity1 . Bodies retrieved from a water medium pose several challenges to the forensic pathologist with the diagnosis of drowning being primarily one of exclusion. The aim of this study was to do a retrospective descriptive case audit of bodies retrieved from water and immersion related @entity1 , which were investigated at the Pretoria Medico-Legal Laboratory (PMLL) over a 10 year period (January 2002 through December 2011). A total of 346 cases were identified for inclusion into this study. In 6% (20) of these cases, the @entity1 was not related to drowning; in 14% (48) no clear cause of @entity1 could be ascertained and in 278 cases (80%) the cause of @entity1 was considered to have been due to drowning. @entity0 (under 1 year, of age) constituted 41 (15%) of the cases; toddlers (aged 1-2 years) comprised 52 (19%) cases; @entity0 (aged 2-13 years) 49 (18%) cases; adolescents (aged 13-18 years) comprised 10 (3%) cases; adults (above 18, years) made up 126 (45%) of the cases. The majority of the drownings, occurred in swimming pools [125 cases (38%)]. In @entity0 23 (56%) of, drownings occurred in swimming pools followed by buckets [7 cases (17%)]. Sixty-nine per cent of toddler drownings (36 cases) occurred in swimming, pools. In the adult population, 40 (32%) of cases occurred in pools and 35 cases (28%) in rivers. Positive blood alcohol results were recorded in 48, (42%) out of 113 cases where the test was requested, 40 (35%) of these, cases higher than 0.05  g per 100  ml. This study suggests that many @entity1 in Pretoria may be preventable by introducing greater public awareness of the risks and instituting relatively simple, protective measures.

title: XXXX in Pretoria, South Africa: A 10-year review.

answer: @entity2


abstract: BACKGROUND: Joint-sparing surgery of a @entity0 's native joint for @entity5 likely affords better function and comparable survival. However, it sometimes is challenging to resect a @entity5 in a way that preserves the affected epiphysis because wide margins are necessary to minimize the risk of local recurrence. If there was a method to resect a @entity1 close to the joint and treat a potentially positive margin to prevent recurrence, it might allow salvage of a joint that otherwise might be lost. QUESTIONS/PURPOSES: We therefore asked (1) whether joint-preserving @entity1 resection could be performed for @entity5 after microwave ablation of the @entity1 edge under navigation without leading to local recurrences, (2) what is the resulting function, and (3) what are the complications associated with this procedure. METHODS: Between 2009 and 2011, we treated 11 @entity0 who had @entity5 of the proximal tibia (mean age, 12 years; range, 9-16 years) with joint-preserving surgery by transepiphysis @entity1 resection after navigation-assisted microwave ablation of the @entity1 edge; they were followed a minimum of 37 months (mean, 48 months; range 37-62 months), and none was lost to followup. @entity0 were considered eligible for this procedure if they had a distance from the @entity1 edge to the articular surface between 10 to 15 mm, good chemotherapy responses, no pathologic @entity3 and no @entity1 involvement of major @entity6 . Allograft in combination with a vascularized fibula flap was used for segmental reconstruction. We recorded @entity1 control, complications, and functional outcomes using the @entity2 Society score, which ranges from 0 to 30, with higher scores indicating better function. RESULTS: There were no local recurrences. Major complications included @entity7 of part of the epiphysis in two @entity0 and @entity4 in one. The @entity2 Society score ranged from 26 to 30 with a mean of 29. CONCLUSIONS: In selected @entity0 with @entity5 invading the epiphysis, navigated resection facilitates performing joint-sparing surgery, and in our small series, the adjuvant microwave ablation seemed to provide adequate @entity1 control. Although more experience and longer followup are needed, this approach may make it possible to salvage more native joints when performing limb salvage for @entity5 . LEVEL OF EVIDENCE: Level IV, therapeutic study.

title: Does Microwave Ablation of the Tumor Edge Allow for Joint-sparing Surgery in @entity0 With XXXX of the Proximal Tibia?

answer: @entity5


abstract: BACKGROUND: Joint-sparing surgery of a @entity0 's native joint for @entity5 likely affords better function and comparable survival. However, it sometimes is challenging to resect a @entity5 in a way that preserves the affected epiphysis because wide margins are necessary to minimize the risk of local recurrence. If there was a method to resect a @entity1 close to the joint and treat a potentially positive margin to prevent recurrence, it might allow salvage of a joint that otherwise might be lost. QUESTIONS/PURPOSES: We therefore asked (1) whether joint-preserving @entity1 resection could be performed for @entity5 after microwave ablation of the @entity1 edge under navigation without leading to local recurrences, (2) what is the resulting function, and (3) what are the complications associated with this procedure. METHODS: Between 2009 and 2011, we treated 11 @entity0 who had @entity5 of the proximal tibia (mean age, 12 years; range, 9-16 years) with joint-preserving surgery by transepiphysis @entity1 resection after navigation-assisted microwave ablation of the @entity1 edge; they were followed a minimum of 37 months (mean, 48 months; range 37-62 months), and none was lost to followup. @entity0 were considered eligible for this procedure if they had a distance from the @entity1 edge to the articular surface between 10 to 15 mm, good chemotherapy responses, no pathologic @entity3 and no @entity1 involvement of major @entity6 . Allograft in combination with a vascularized fibula flap was used for segmental reconstruction. We recorded @entity1 control, complications, and functional outcomes using the @entity2 Society score, which ranges from 0 to 30, with higher scores indicating better function. RESULTS: There were no local recurrences. Major complications included @entity7 of part of the epiphysis in two @entity0 and @entity4 in one. The @entity2 Society score ranged from 26 to 30 with a mean of 29. CONCLUSIONS: In selected @entity0 with @entity5 invading the epiphysis, navigated resection facilitates performing joint-sparing surgery, and in our small series, the adjuvant microwave ablation seemed to provide adequate @entity1 control. Although more experience and longer followup are needed, this approach may make it possible to salvage more native joints when performing limb salvage for @entity5 . LEVEL OF EVIDENCE: Level IV, therapeutic study.

title: Does Microwave Ablation of the Tumor Edge Allow for Joint-sparing Surgery in XXXX With @entity5 of the Proximal Tibia?

answer: @entity0


abstract: RATIONALE: After adjustment for the amount of smoking, @entity0 have a 50% increased risk of @entity5 ( @entity5 ) compared with @entity0 . The anatomic basis and/or mechanism(s) of these sex-related differences in @entity5 are unknown. OBJECTIVES: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and @entity6 in a @entity1 model of @entity5 . METHODS: Airway remodeling and @entity6 were determined morphometrically in male, female, and ovariectomized @entity1 exposed to 6 months of cigarette smoke. Antioxidant- and transforming growth factor (TGF)-b-related genes were profiled in airway tissues. The selective @entity2 receptor modulator @entity3 was also administered during smoke exposure in a short-term model. Airway wall thickness of male and female @entity0 smokers at risk of or with mild @entity5 was measured using optical coherence tomography. MEASUREMENTS AND MAIN RESULTS: Small airway wall remodeling was increased in female but not male or ovariectomized @entity1 and was associated with increased distal airway resistance, down-regulation of antioxidant genes, increased oxidative stress, and activation of @entity4 . These effects were prevented by ovariectomy. Use of @entity3 as a therapeutic intervention mitigated smoke-induced increase in oxidative stress in female @entity1 . Compared with male @entity0 smokers, female @entity0 smokers had significantly thicker airway walls. CONCLUSIONS: The excess risk of small airway disease in female @entity1 after chronic smoke exposure was associated with increased oxidative stress and @entity4 signaling and also was related to the effects of female sex hormones. @entity2 receptor antagonism might be of value in reducing oxidative stress in female smokers.

title: Sex Differences in Airway Remodeling in a @entity1 Model of XXXX .

answer: @entity5


abstract: RATIONALE: After adjustment for the amount of smoking, @entity0 have a 50% increased risk of @entity5 ( @entity5 ) compared with @entity0 . The anatomic basis and/or mechanism(s) of these sex-related differences in @entity5 are unknown. OBJECTIVES: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and @entity6 in a @entity1 model of @entity5 . METHODS: Airway remodeling and @entity6 were determined morphometrically in male, female, and ovariectomized @entity1 exposed to 6 months of cigarette smoke. Antioxidant- and transforming growth factor (TGF)-b-related genes were profiled in airway tissues. The selective @entity2 receptor modulator @entity3 was also administered during smoke exposure in a short-term model. Airway wall thickness of male and female @entity0 smokers at risk of or with mild @entity5 was measured using optical coherence tomography. MEASUREMENTS AND MAIN RESULTS: Small airway wall remodeling was increased in female but not male or ovariectomized @entity1 and was associated with increased distal airway resistance, down-regulation of antioxidant genes, increased oxidative stress, and activation of @entity4 . These effects were prevented by ovariectomy. Use of @entity3 as a therapeutic intervention mitigated smoke-induced increase in oxidative stress in female @entity1 . Compared with male @entity0 smokers, female @entity0 smokers had significantly thicker airway walls. CONCLUSIONS: The excess risk of small airway disease in female @entity1 after chronic smoke exposure was associated with increased oxidative stress and @entity4 signaling and also was related to the effects of female sex hormones. @entity2 receptor antagonism might be of value in reducing oxidative stress in female smokers.

title: Sex Differences in Airway Remodeling in a XXXX Model of @entity5 .

answer: @entity1


abstract: UNASSIGNED: Objectives Some injured workers with work-related, @entity2 experience a troubling course in return to work. A prediction tool was developed in an earlier study, using administrative data only. This study explored the added value of worker reported data in identifying those workers with @entity2 at higher risk of being on benefits for a longer period of time. Methods This was a cohort study of workers with @entity2 in 2005 in Ontario. Workplace Safety and Insurance Board (WSIB) data was used. As well, we examined the added value of @entity0 -reported prognostic factors obtained from a prospective cohort study. Improvement of model fit was determined by comparing area under the curve (AUC) statistics. The outcome measure was time on benefits during a first workers' compensation claim for @entity2 . Follow-up was 2  years. Results Among 1442 workers with WSIB data still on full benefits at 4  weeks, 113 were also part of the prospective cohort study. Model fit of an established rule in the smaller dataset of 113 workers was comparable to the fit previously established in the larger dataset. Adding worker rating of @entity1 at baseline improved the rule substantially (AUC  =  0.80, 95  % CI 0.68, 0.91 compared to benefit status at 180  days, AUC  =  0.88, 95  % CI 0.74, 1.00 compared to benefits status at 360  days). Conclusion Although data routinely collected by workers' compensation boards show some ability to predict prolonged time on benefits, adding information on experienced @entity1 reported by the worker improves the predictive ability of the model from 'fairly good' to 'good'. In this study, a combination of prognostic factors, reported by multiple stakeholders, including the worker, could identify those at high risk of extended duration on disability benefits and in potentially in need of additional support at the individual level.

title: The Added Value of Collecting Information on XXXX Experience When Predicting Time on Benefits for Injured Workers with Back @entity1 .

answer: @entity1


abstract: UNASSIGNED: Objectives Some injured workers with work-related, @entity2 experience a troubling course in return to work. A prediction tool was developed in an earlier study, using administrative data only. This study explored the added value of worker reported data in identifying those workers with @entity2 at higher risk of being on benefits for a longer period of time. Methods This was a cohort study of workers with @entity2 in 2005 in Ontario. Workplace Safety and Insurance Board (WSIB) data was used. As well, we examined the added value of @entity0 -reported prognostic factors obtained from a prospective cohort study. Improvement of model fit was determined by comparing area under the curve (AUC) statistics. The outcome measure was time on benefits during a first workers' compensation claim for @entity2 . Follow-up was 2  years. Results Among 1442 workers with WSIB data still on full benefits at 4  weeks, 113 were also part of the prospective cohort study. Model fit of an established rule in the smaller dataset of 113 workers was comparable to the fit previously established in the larger dataset. Adding worker rating of @entity1 at baseline improved the rule substantially (AUC  =  0.80, 95  % CI 0.68, 0.91 compared to benefit status at 180  days, AUC  =  0.88, 95  % CI 0.74, 1.00 compared to benefits status at 360  days). Conclusion Although data routinely collected by workers' compensation boards show some ability to predict prolonged time on benefits, adding information on experienced @entity1 reported by the worker improves the predictive ability of the model from 'fairly good' to 'good'. In this study, a combination of prognostic factors, reported by multiple stakeholders, including the worker, could identify those at high risk of extended duration on disability benefits and in potentially in need of additional support at the individual level.

title: The Added Value of Collecting Information on @entity1 Experience When Predicting Time on Benefits for Injured Workers with Back XXXX .

answer: @entity1


abstract: OBJECTIVE: This study aimed to identify the impact of preoperative colonoscopic tattooing (PCT) on lymph node harvest in T1 @entity1 @entity0 . MATERIAL AND METHODS: One hundred and forty-three @entity0 were included who underwent curative resection and were diagnosed with T1 @entity1 . These @entity0 were categorized into the tattooing group and the non-tattooing group depending on whether preoperative India ink tattooing was done. Clinicopathological findings and lymph node harvest were compared between the two groups. RESULTS: The median number of lymph nodes examined was 18 in the tattooing group and 13 in the non-tattooing group (p   <   0.001). The rate of adequate lymph node harvest (retrieval of more than 12 lymph nodes) was higher in the tattooing group than that in the non-tattooing group (83.7 vs. 58.5  %, p   =   0.002). The PCT was significantly associated with adequate lymph node harvest in multivariate analysis (hazard ratio, 3.8; 95  % confidence interval, 1.5-9.2; p   =   0.003). Among the 40 @entity0 who showed at least one @entity2 particle-containing lymph nodes, the positive lymph node rate was not different between @entity2 -containing LNs (0.9  %) and non- @entity2 -containing LNs (1.7  %). CONCLUSIONS: PCT was associated with higher lymph node yield in T1 @entity1 . It is questionable if tattooing has additional detection power as a sentinel lymph node mapping tool in T1 @entity1 .

title: Effect of preoperative colonoscopic tattooing on lymph node harvest in T1 XXXX .

answer: @entity1


abstract: OBJECTIVES/HYPOTHESIS: To examine associations between @entity7 ( @entity7 ) care and pretreatment variables, swallowing and @entity3 , and survival in elderly @entity0 treated for @entity1 . STUDY DESIGN: Retrospective analysis of surveillance, epidemiology, and end results (SEER)-Medicare data. METHODS: We evaluated longitudinal data from 2,370 @entity0 diagnosed with @entity1 from 2004 to 2007 using cross-tabulations, multivariate logistic regression, and survival analysis. RESULTS: Initial treatment with total laryngectomy (odds ratio [OR]   =   3.3 [1.6-6.8]), and @entity6 during treatment (OR   =   4.0 [2.2-7.2]) were the only significant predictors of @entity7 care during the initial treatment period. Speech-language pathology care was more likely during the first year (OR   =   4.1 [2.7-6.0]) and second year (OR   =   1.6 [1.1-2.3]) following initial treatment; however, only 23.7% of @entity0 ever received @entity7 care. Pretreatment tracheostomy tube placement (OR   =   2.8 [1.1-7.0]), initial treatment with total laryngectomy (OR   =   3.4 [2.0-5.6]), @entity6 (OR   =   7.6 [5.5-10.4]), stricture (OR   =   1.9 [1.1-3.1]), interval tracheostomy tube placement (OR   =   3.5 [2.4-5.2]), and salvage surgery (OR   =   3.1 [1.6-5.8]) were significantly associated with long-term @entity7 care. After controlling for relevant variables, @entity7 care was associated with significant relative attenuation of the OR for @entity6 (50%), stricture (26%), @entity5 (20%), and @entity2 (21%). Hazards ratio for @entity4 , if under @entity7 care, was 0.83 (0.70-0.99). CONCLUSION: @entity7 care is underutilized in elderly @entity1 @entity0 and is largely reserved for select patients in anticipation of total laryngectomy or after the onset of impaired airway and swallowing function, but is associated with improved outcomes. These data suggest a need for treatment guidelines that incorporate the routine use of @entity7 care during the initial treatment period and beyond. LEVEL OF EVIDENCE: 2c. Laryngoscope, 2015.

title: Speech-language pathology care and short- and long-term outcomes of XXXX treatment in the elderly.

answer: @entity1


abstract: Many plant growth and developmental processes are modulated by the hormone auxin. Auxin-modulated proteolysis of Aux/IAAs, a family of transcriptional repressors, represents a major mode of auxin action. Auxin facilitates the interaction of Aux/IAAs with @entity1 /AFB F-box proteins, promoting their ubiquitination by the SCF( @entity1 /AFB) ubiquitin E3 ligase leading to subsequent degradation by the 26S proteasome. To identify new genes regulating Aux/IAA proteolysis in @entity0 , we took a genetic approach, identifying individuals with altered degradation of an @entity2 -luciferase fusion protein ( @entity2 -LUC). A mutant with 2-fold slower @entity2 -LUC degradation rate compared with wild-type was isolated. Positional cloning identified the mutant as an allele of TOPOISOMERASE6B, named @entity3 -7. @entity3 encodes a subunit of a plant and archea-specific enzyme regulating endoreduplication, DNA damage repair and transcription in plants. T-DNA insertion alleles ( @entity3 -8 and @entity3 -9) were also analyzed. @entity3 -7 seedlings are less sensitive to exogenous auxin than wild-type siblings in primary root growth assays, and experiments with DR5:GUS. Additionally, @entity3 -7 seedlings have a 40% reduction in the amount of endogenous IAA. These data suggest that increased @entity2 -LUC half-life in @entity3 -7 probably results from a combination of both lower endogenous IAA levels and reduced sensitivity to auxin.

title: A genetic screen for mutants defective in XXXX -LUC degradation in @entity0 reveals an important requirement for TOPOISOMERASE6B in auxin physiology.

answer: @entity2


abstract: Many plant growth and developmental processes are modulated by the hormone auxin. Auxin-modulated proteolysis of Aux/IAAs, a family of transcriptional repressors, represents a major mode of auxin action. Auxin facilitates the interaction of Aux/IAAs with @entity1 /AFB F-box proteins, promoting their ubiquitination by the SCF( @entity1 /AFB) ubiquitin E3 ligase leading to subsequent degradation by the 26S proteasome. To identify new genes regulating Aux/IAA proteolysis in @entity0 , we took a genetic approach, identifying individuals with altered degradation of an @entity2 -luciferase fusion protein ( @entity2 -LUC). A mutant with 2-fold slower @entity2 -LUC degradation rate compared with wild-type was isolated. Positional cloning identified the mutant as an allele of TOPOISOMERASE6B, named @entity3 -7. @entity3 encodes a subunit of a plant and archea-specific enzyme regulating endoreduplication, DNA damage repair and transcription in plants. T-DNA insertion alleles ( @entity3 -8 and @entity3 -9) were also analyzed. @entity3 -7 seedlings are less sensitive to exogenous auxin than wild-type siblings in primary root growth assays, and experiments with DR5:GUS. Additionally, @entity3 -7 seedlings have a 40% reduction in the amount of endogenous IAA. These data suggest that increased @entity2 -LUC half-life in @entity3 -7 probably results from a combination of both lower endogenous IAA levels and reduced sensitivity to auxin.

title: A genetic screen for mutants defective in @entity2 -LUC degradation in XXXX reveals an important requirement for TOPOISOMERASE6B in auxin physiology.

answer: @entity0


abstract: BACKGROUND: Our goal was to perform a systematic review of the literature on the use of therapeutic @entity6 for @entity1 ( @entity1 ) and its impact on @entity3 control. METHODS: All articles from MEDLINE, BIOSIS, EMBASE, Global Health, HealthStar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform (inception to May 2014), reference lists of relevant articles, and gray literature were searched. The strength of evidence was adjudicated by two independent reviewers, using both the Oxford and GRADE methodology. RESULTS: Overall, 13 studies were identified, with 10 manuscripts and 3 meeting abstracts. A total of 40 @entity0 were treated. The common target temperature was 33 degrees Celsius, sustained for a median 48 hours. @entity0 displayed a 62.5%, 15% and 22.5% rate of @entity3 cessation, @entity3 reduction, and failure of treatment respectively. External cooling was utilized in the majority of cases. @entity5 , @entity4 and @entity2 were the commonly reported complications. Two ongoing clinical trials were identified. CONCLUSIONS: Oxford level 4, GRADE D evidence exists to support the use of therapeutic @entity6 to control @entity3 in @entity1 . Further prospective study is warranted.

title: Therapeutic @entity6 for XXXX .

answer: @entity1


abstract: BACKGROUND: Our goal was to perform a systematic review of the literature on the use of therapeutic @entity6 for @entity1 ( @entity1 ) and its impact on @entity3 control. METHODS: All articles from MEDLINE, BIOSIS, EMBASE, Global Health, HealthStar, Scopus, Cochrane Library, the International Clinical Trials Registry Platform (inception to May 2014), reference lists of relevant articles, and gray literature were searched. The strength of evidence was adjudicated by two independent reviewers, using both the Oxford and GRADE methodology. RESULTS: Overall, 13 studies were identified, with 10 manuscripts and 3 meeting abstracts. A total of 40 @entity0 were treated. The common target temperature was 33 degrees Celsius, sustained for a median 48 hours. @entity0 displayed a 62.5%, 15% and 22.5% rate of @entity3 cessation, @entity3 reduction, and failure of treatment respectively. External cooling was utilized in the majority of cases. @entity5 , @entity4 and @entity2 were the commonly reported complications. Two ongoing clinical trials were identified. CONCLUSIONS: Oxford level 4, GRADE D evidence exists to support the use of therapeutic @entity6 to control @entity3 in @entity1 . Further prospective study is warranted.

title: Therapeutic XXXX for @entity1 .

answer: @entity6


abstract: BACKGROUND: Survival has steadily improved for major @entity2 types in most parts of the world. We compared all-cause mortality between foreign-born and Sweden-born residents of Sweden who were diagnosed with @entity4 , lung, stomach, prostate, breast, cervix, and all site. METHODS: We used Swedish national vital status and health registers to follow a cohort of 1,556,108 @entity1 45 years of age and older diagnosed with @entity2 between 1961 and 2009 in Sweden. Among them, 109,915 were born abroad. We estimated hazard ratios (HR) and 95% confidence interval (CI) using multivariable Cox proportional hazard models. RESULTS: We identified 604,035 and 540,138 @entity3 among @entity1 and @entity1 , respectively. Among them 33,595 @entity1 and 34,174 @entity1 were born abroad. At the time of diagnosis, @entity1 born abroad were on average 4 years younger than @entity1 born in Sweden. All-cause mortality was generally lower in the former than in the latter group of @entity1 before 1990 but higher after 2000. The mortality trend was similar for prostate and @entity0 . CONCLUSIONS: Whilst national policy in Sweden aims at achieving equal access to health care, the mortality trend observed among @entity2 @entity1 born in Sweden was different from that observed among @entity1 born elsewhere. Mortality after diagnosis of major types of @entity2 has worsened among foreign-born after the year 2000. The possible determinants of disparities need be identified and investigated.

title: Trends in mortality after XXXX diagnosis: A nationwide cohort study over 45 years of follow-up in Sweden by country of birth.

answer: @entity2


abstract: This study aimed to investigate the relationship between type I interferon (IFN-I) and plaque stability in @entity8 -treated @entity7 -knockout ( @entity7 (-/-)) mice. Antinuclear antibody (ANA) and extractable nuclear antigen antibody (ENA) levels were measured by immunofluorescence and enzyme-linked immunospot assay. @entity3 were detected by Sirius red/fast green staining. Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated @entity6 - @entity5 nick-end labeling. Gene expression was determined by real-time PCR analyses. We found that @entity8 -treated @entity7 (-/-) @entity1 developed @entity4 characterized by an increased production of serum ANA and ENA. @entity8 treatment decreased the collagen content and increased the number of apoptotic cells in plaques. Moreover, IFN-induced @entity9 , IFIT1-1, and IFIT1-2 gene expression was increased in peripheral blood cells and aortic plaques. An IFN-a-stimulated macrophage supernatant inhibited collagen type I, alpha 1 gene expression in vascular smooth muscle cells. We concluded that the vulnerability of plaques was associated with the activation of IFN-I in @entity8 -treated @entity7 (-/-) @entity1 . Thus, we speculated that the higher prevalence of @entity2 in @entity0 with @entity4 could be due to plaque instability.

title: Vulnerability of @entity3 plaques is as-sociated with type I interferon in a @entity1 model of XXXX and @entity3 .

answer: @entity4


abstract: This study aimed to investigate the relationship between type I interferon (IFN-I) and plaque stability in @entity8 -treated @entity7 -knockout ( @entity7 (-/-)) mice. Antinuclear antibody (ANA) and extractable nuclear antigen antibody (ENA) levels were measured by immunofluorescence and enzyme-linked immunospot assay. @entity3 were detected by Sirius red/fast green staining. Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated @entity6 - @entity5 nick-end labeling. Gene expression was determined by real-time PCR analyses. We found that @entity8 -treated @entity7 (-/-) @entity1 developed @entity4 characterized by an increased production of serum ANA and ENA. @entity8 treatment decreased the collagen content and increased the number of apoptotic cells in plaques. Moreover, IFN-induced @entity9 , IFIT1-1, and IFIT1-2 gene expression was increased in peripheral blood cells and aortic plaques. An IFN-a-stimulated macrophage supernatant inhibited collagen type I, alpha 1 gene expression in vascular smooth muscle cells. We concluded that the vulnerability of plaques was associated with the activation of IFN-I in @entity8 -treated @entity7 (-/-) @entity1 . Thus, we speculated that the higher prevalence of @entity2 in @entity0 with @entity4 could be due to plaque instability.

title: Vulnerability of XXXX plaques is as-sociated with type I interferon in a @entity1 model of @entity4 and @entity3 .

answer: @entity3


abstract: This study aimed to investigate the relationship between type I interferon (IFN-I) and plaque stability in @entity8 -treated @entity7 -knockout ( @entity7 (-/-)) mice. Antinuclear antibody (ANA) and extractable nuclear antigen antibody (ENA) levels were measured by immunofluorescence and enzyme-linked immunospot assay. @entity3 were detected by Sirius red/fast green staining. Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated @entity6 - @entity5 nick-end labeling. Gene expression was determined by real-time PCR analyses. We found that @entity8 -treated @entity7 (-/-) @entity1 developed @entity4 characterized by an increased production of serum ANA and ENA. @entity8 treatment decreased the collagen content and increased the number of apoptotic cells in plaques. Moreover, IFN-induced @entity9 , IFIT1-1, and IFIT1-2 gene expression was increased in peripheral blood cells and aortic plaques. An IFN-a-stimulated macrophage supernatant inhibited collagen type I, alpha 1 gene expression in vascular smooth muscle cells. We concluded that the vulnerability of plaques was associated with the activation of IFN-I in @entity8 -treated @entity7 (-/-) @entity1 . Thus, we speculated that the higher prevalence of @entity2 in @entity0 with @entity4 could be due to plaque instability.

title: Vulnerability of @entity3 plaques is as-sociated with type I interferon in a @entity1 model of @entity4 and XXXX .

answer: @entity3


abstract: This study aimed to investigate the relationship between type I interferon (IFN-I) and plaque stability in @entity8 -treated @entity7 -knockout ( @entity7 (-/-)) mice. Antinuclear antibody (ANA) and extractable nuclear antigen antibody (ENA) levels were measured by immunofluorescence and enzyme-linked immunospot assay. @entity3 were detected by Sirius red/fast green staining. Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated @entity6 - @entity5 nick-end labeling. Gene expression was determined by real-time PCR analyses. We found that @entity8 -treated @entity7 (-/-) @entity1 developed @entity4 characterized by an increased production of serum ANA and ENA. @entity8 treatment decreased the collagen content and increased the number of apoptotic cells in plaques. Moreover, IFN-induced @entity9 , IFIT1-1, and IFIT1-2 gene expression was increased in peripheral blood cells and aortic plaques. An IFN-a-stimulated macrophage supernatant inhibited collagen type I, alpha 1 gene expression in vascular smooth muscle cells. We concluded that the vulnerability of plaques was associated with the activation of IFN-I in @entity8 -treated @entity7 (-/-) @entity1 . Thus, we speculated that the higher prevalence of @entity2 in @entity0 with @entity4 could be due to plaque instability.

title: Vulnerability of @entity3 plaques is as-sociated with type I interferon in a XXXX model of @entity4 and @entity3 .

answer: @entity1


abstract: UNASSIGNED: African Americans and Hispanics have disproportionate rates of uncontrolled essential @entity1 (EH) compared to Non-Hispanic Whites. Medication non-adherence (MNA) is the leading modifiable behavior to improved blood pressure (BP) control. The Smartphone Medication Adherence Stops @entity1 (SMASH) program was developed using a @entity0 -centered, theory-guided, iterative design process. Electronic medication trays provided reminder signals, and Short Message Service [SMS] messaging reminded subjects to monitor BP with Bluetooth-enabled monitors. Motivational and reinforcement text messages were sent to @entity0 based upon levels of adherence. Thirty-eight African-American (18) and Hispanic (20) uncontrolled @entity1 completed clinic-based anthropometric and resting BP evaluations prior to randomization, and again at months 1, 3 and 6. Generalized linear mixed modeling (GLMM) revealed statistically significant time-by-treatment interactions (p < 0.0001) indicating significant reductions in resting systolic blood pressure (SBP) and diastolic blood pressure (DBP) for the SMASH group vs. the standard care (SC) control group across all time points. 70.6% of SMASH subjects vs. 15.8% of the SC group reached BP control (< 140/90 mmH) at month 1 (p < 0.001). At month 6, 94.4% of the SMASH vs. 41.2% of the SC group exhibited controlled BP (p < 0.003). Our findings provide encouraging evidence that efficacious mHealth, chronic disease, medical regimen, self-management programs can be developed following principles of @entity0 -centered, theory-guided design.

title: Evaluation of an mHealth Medication Regimen Self-Management Program for African American and Hispanic Uncontrolled XXXX .

answer: @entity1