abstract: OBJECTIVE: To investigate the relevance between the expression of P-170 and @entity3 and clinical drug resistance in @entity2 . METHODS: The expression of P-170 and @entity3 in mononuclear cells of bone marrows was analyzed by the immunohistochemical technique in 72 @entity2 @entity0 . RESULTS: The expression of P-170 was positive in 46 and negative in 26 of the 72 post-chemotherapy @entity2 @entity0 . The therapeutic effect of the P-170 positive expression @entity0 was significantly poorer than that of the negative expression @entity0 (P < 0.01). The expression of @entity3 was positive in 39 and negative in 33 of the 72 post-chemotherapy @entity2 @entity0 . The therapeutic effect of the @entity3 positive expression @entity0 was significantly poorer than that in the negative expression @entity0 (P < 0.01). The expression of P-170 and @entity3 had a significant concordance (Kappa = 0.427, P < 0.01). The sensitivity of P-170 and @entity3 which were analyzed simultaneously was 97.5%, which was higher than that of P-170 (90%) or @entity3 (77.5%) analyzed respectively in drug resistance @entity0 . CONCLUSION: The expression of P-170 and/or @entity3 was significantly related with drug resistance in clinical chemotherapy. The therapeutic effect was significantly poorer in P-170 and/or @entity3 positive expression @entity0 than that in negative expression @entity0 . These data suggest that P-170 and @entity3 analyzed simultaneously can improve the value of diagnosis and prognosis in @entity0 with @entity1 .

title: [Expression of multidrug resistance P-170 and @entity3 and their correlation with clinical drug resistance in XXXX ].

answer: @entity2


abstract: OBJECTIVE: To investigate the relevance between the expression of P-170 and @entity3 and clinical drug resistance in @entity2 . METHODS: The expression of P-170 and @entity3 in mononuclear cells of bone marrows was analyzed by the immunohistochemical technique in 72 @entity2 @entity0 . RESULTS: The expression of P-170 was positive in 46 and negative in 26 of the 72 post-chemotherapy @entity2 @entity0 . The therapeutic effect of the P-170 positive expression @entity0 was significantly poorer than that of the negative expression @entity0 (P < 0.01). The expression of @entity3 was positive in 39 and negative in 33 of the 72 post-chemotherapy @entity2 @entity0 . The therapeutic effect of the @entity3 positive expression @entity0 was significantly poorer than that in the negative expression @entity0 (P < 0.01). The expression of P-170 and @entity3 had a significant concordance (Kappa = 0.427, P < 0.01). The sensitivity of P-170 and @entity3 which were analyzed simultaneously was 97.5%, which was higher than that of P-170 (90%) or @entity3 (77.5%) analyzed respectively in drug resistance @entity0 . CONCLUSION: The expression of P-170 and/or @entity3 was significantly related with drug resistance in clinical chemotherapy. The therapeutic effect was significantly poorer in P-170 and/or @entity3 positive expression @entity0 than that in negative expression @entity0 . These data suggest that P-170 and @entity3 analyzed simultaneously can improve the value of diagnosis and prognosis in @entity0 with @entity1 .

title: [Expression of multidrug resistance P-170 and XXXX and their correlation with clinical drug resistance in @entity2 ].

answer: @entity3


abstract: Sex hormones are known to interfere with the @entity2 -angiotensin- @entity4 system (RAAS) in two ways. First, @entity1 strongly stimulate the production of @entity2 substrate ( @entity8 ), leading to increased levels of angiotensin and @entity4 , and @entity5 retention. Second, @entity6 is a potent @entity4 antagonist, which acts on the mineralocorticoid receptor to prevent @entity5 retention. In combined oral contraceptives, progestogens devoid of antimineralocorticoid and antiandrogenic activity are unable to counteract the @entity5 -retaining effect of the @entity7 component. As a consequence, these preparations may increase @entity10 , and promote related symptoms such as @entity0 and body weight. @entity9 is a new progestogen with antimineralocorticoid and antiandrogenic activity. The relationship between the progestogenie and antimincralocorticoid potency of @entity9 is similar to that of endogenous @entity6 . At a dosage that suppresses ovulation, @entity9 induces mild natriuresis, which is followed by compensatory stimulation of the RAAS (comparable to a low @entity5 diet). An oral contraceptive containing 3 mg @entity9 and 30 microg @entity7 . (Yasmin, Schering AG, Berlin, Germany) provides reliable contraception and, due to a lack of @entity5 retention, may counteract cyclical @entity3 and other symptoms related to @entity1 -induced @entity10 .

title: Antimineralocorticoid activity of a novel oral contraceptive containing @entity9 , a unique progestogen resembling natural XXXX .

answer: @entity6


abstract: Sex hormones are known to interfere with the @entity2 -angiotensin- @entity4 system (RAAS) in two ways. First, @entity1 strongly stimulate the production of @entity2 substrate ( @entity8 ), leading to increased levels of angiotensin and @entity4 , and @entity5 retention. Second, @entity6 is a potent @entity4 antagonist, which acts on the mineralocorticoid receptor to prevent @entity5 retention. In combined oral contraceptives, progestogens devoid of antimineralocorticoid and antiandrogenic activity are unable to counteract the @entity5 -retaining effect of the @entity7 component. As a consequence, these preparations may increase @entity10 , and promote related symptoms such as @entity0 and body weight. @entity9 is a new progestogen with antimineralocorticoid and antiandrogenic activity. The relationship between the progestogenie and antimincralocorticoid potency of @entity9 is similar to that of endogenous @entity6 . At a dosage that suppresses ovulation, @entity9 induces mild natriuresis, which is followed by compensatory stimulation of the RAAS (comparable to a low @entity5 diet). An oral contraceptive containing 3 mg @entity9 and 30 microg @entity7 . (Yasmin, Schering AG, Berlin, Germany) provides reliable contraception and, due to a lack of @entity5 retention, may counteract cyclical @entity3 and other symptoms related to @entity1 -induced @entity10 .

title: Antimineralocorticoid activity of a novel oral contraceptive containing XXXX , a unique progestogen resembling natural @entity6 .

answer: @entity9


abstract: OBJECT: Although infrequent, injury to adjacent @entity1 during posterior approaches to lumbar intervertebral discs can occur. A detailed anatomical knowledge of relationships @entity2 . METHODS: Ten @entity0 -fixed male cadavers were used for this study. Posterior exposure of the lumbar thecal sac, nerve roots, pedicles, and intervertebral discs was performed. To identify retroperitoneal structures at risk during posterior lumbar discectomy, a transabdominal retroperitoneal approach was performed, and observations were made. The distances between the posterior and anterior edges of the lumbar intervertebral discs were measured, and the relationships between the disc space, pedicle, and nerve root were evaluated. RESULTS: For right and left sides, the mean distance from the inferior pedicle to the disc gradually increased from @entity3 to L4-5 (range 2.7-3.8 mm and 2.9-4.5 mm for right and left side, respectively) and slightly decreased at L5-S1. For right and left sides, the mean distance from the superior pedicle to the disc was more or less the same for all disc spaces (range 9.3-11.6 mm and 8.2-10.5 mm for right and left, respectively). The right and left mean disc-to-root distance for the @entity4 to L5-S1 levels ranged from 8.3 to 22.1 mm and 7.2 to 20.6 mm, respectively. The root origin gradually increased from L-1 to L-5. The right and left nerve root-to-disc angle gradually decreased from L-3 to S-1 (range 105  -110.6   and 99  -108  ). Disc heights gradually increased from @entity3 to L5-S1 (range 11.3-17.4 mm). The mean distance between the anterior and posterior borders of the intervertebral discs ranged from 39 to 46 mm for all levels. CONCLUSIONS: To avoid neighboring @entity1 , instrumentation should not be inserted into the lumbar disc spaces more than 3 cm from their posterior edge. Accurate anatomical knowledge of the relationships of intervertebral discs to nerve roots is needed for spine surgeons.

title: XXXX adjacent to the lumbar intervertebral discs: an anatomical study of their morphometry and relationships.

answer: @entity1


abstract: BACKGROUND: @entity0 with @entity4 have a high risk of @entity2 ( @entity2 ). @entity5 ( @entity5 ) improve peak @entity1 uptake (VO(2peak)), net mechanical efficiency of walking and risk factors for @entity2 but has not been investigated in @entity0 with @entity4 . AIMS: To investigate effects from @entity5 on VO(2peak), net mechanical efficiency of walking and risk factors for @entity2 in @entity0 with @entity4 . METHODS: 25 inpatients (F20-29, ICD-10) were allocated to either @entity5 or playing computer games (CG), 3 days per week for 8 weeks. @entity5 consisted of 4   4-min intervals with 3-min break periods, at 85-95% and 70% of peak heart rate, respectively. RESULTS: 12 and seven @entity0 completed @entity5 and CG, respectively. The baseline VO(2peak) in both groups combined (n = 19) was 36.8    8.2 ml/kg/min and 3.12    0.55 l/min. The @entity5 group improved VO(2peak) by 12% from 3.17    0.59 to 3.56    0.68 l/min (P < 0.001), more than the CG group (P = 0.014). Net mechanical efficiency of walking improved by 12% in the @entity5 group from 19.8    3.0% to 22.2    4.5% (P = 0.005), more than the CG group (P = 0.031). The @entity3 symptoms, expressed as the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for @entity4 (CDSS), did not improve in either group. CONCLUSIONS: VO(2peak) and net mechanical efficiency of walking improved significantly by 8 weeks of @entity5 . @entity5 should be included in rehabilitation in order to improve physical capacity and contribute risk reduction of @entity2 .

title: Effects of high aerobic intensity training in @entity0 with XXXX : a controlled trial.

answer: @entity4


abstract: BACKGROUND: @entity0 with @entity4 have a high risk of @entity2 ( @entity2 ). @entity5 ( @entity5 ) improve peak @entity1 uptake (VO(2peak)), net mechanical efficiency of walking and risk factors for @entity2 but has not been investigated in @entity0 with @entity4 . AIMS: To investigate effects from @entity5 on VO(2peak), net mechanical efficiency of walking and risk factors for @entity2 in @entity0 with @entity4 . METHODS: 25 inpatients (F20-29, ICD-10) were allocated to either @entity5 or playing computer games (CG), 3 days per week for 8 weeks. @entity5 consisted of 4   4-min intervals with 3-min break periods, at 85-95% and 70% of peak heart rate, respectively. RESULTS: 12 and seven @entity0 completed @entity5 and CG, respectively. The baseline VO(2peak) in both groups combined (n = 19) was 36.8    8.2 ml/kg/min and 3.12    0.55 l/min. The @entity5 group improved VO(2peak) by 12% from 3.17    0.59 to 3.56    0.68 l/min (P < 0.001), more than the CG group (P = 0.014). Net mechanical efficiency of walking improved by 12% in the @entity5 group from 19.8    3.0% to 22.2    4.5% (P = 0.005), more than the CG group (P = 0.031). The @entity3 symptoms, expressed as the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for @entity4 (CDSS), did not improve in either group. CONCLUSIONS: VO(2peak) and net mechanical efficiency of walking improved significantly by 8 weeks of @entity5 . @entity5 should be included in rehabilitation in order to improve physical capacity and contribute risk reduction of @entity2 .

title: Effects of high aerobic intensity training in XXXX with @entity4 : a controlled trial.

answer: @entity0


abstract: This study was designed to investigate whether flaxseed oil (FO) exerts hypocholesterolemic effects similar to ground @entity4 ( @entity4 ) and to gain insight into its hypocholesterolemic mechanism. Forty-eight 6-month-old female Golden @entity1 were either sham-operated (Sham) or ovariectomized (Ovx) and randomly assigned to one of four treatment groups (n   =   12/group) for 90 days: Sham, Ovx, Ovx+ @entity4 , or Ovx+FO. Hamsters in the Sham and Ovx groups were fed a semipurified diet (control), whereas Ovx+ @entity4 and Ovx+FO received the same basic diet supplemented with either @entity4 (15% wt/wt) or FO (amount equivalent to the oil contribution of @entity4 ). Ovariectomy significantly (P   <   .05) increased serum total concentrations by approximately 15%. @entity4 , but not FO, prevented (P   <   .05) the ovariectomy-induced increase in serum total @entity0 concentration (12% and 4% reduction by @entity4 and FO, respectively). Hamsters fed FO or @entity4 had high-density lipoprotein (HDL)- @entity0 concentrations similar to those of the Ovx hamsters receiving the control diet. Non-HDL- @entity0 concentrations were lowest in the @entity4 group, albeit not statistically different from the other treatment groups. There were no significant differences among groups in serum @entity2 concentration and liver lipids. Both @entity4 and FO more than doubled the hepatic protein levels of 7a-hydroxylase in comparison to the Ovx hamsters receiving the control diet (P   <   .05). Our findings suggest that increased @entity3 synthesis is one of the major @entity0 -lowering mechanisms of flaxseed and that other flaxseed components, aside from its oil, contribute to its hypocholesterolemic property. The @entity0 -lowering effects of other components of flaxseed and their mechanisms of action need to be further explored.

title: Flaxseed but not flaxseed oil prevented the rise in serum @entity0 due to ovariectomy in the Golden XXXX .

answer: @entity1


abstract: This study was designed to investigate whether flaxseed oil (FO) exerts hypocholesterolemic effects similar to ground @entity4 ( @entity4 ) and to gain insight into its hypocholesterolemic mechanism. Forty-eight 6-month-old female Golden @entity1 were either sham-operated (Sham) or ovariectomized (Ovx) and randomly assigned to one of four treatment groups (n   =   12/group) for 90 days: Sham, Ovx, Ovx+ @entity4 , or Ovx+FO. Hamsters in the Sham and Ovx groups were fed a semipurified diet (control), whereas Ovx+ @entity4 and Ovx+FO received the same basic diet supplemented with either @entity4 (15% wt/wt) or FO (amount equivalent to the oil contribution of @entity4 ). Ovariectomy significantly (P   <   .05) increased serum total concentrations by approximately 15%. @entity4 , but not FO, prevented (P   <   .05) the ovariectomy-induced increase in serum total @entity0 concentration (12% and 4% reduction by @entity4 and FO, respectively). Hamsters fed FO or @entity4 had high-density lipoprotein (HDL)- @entity0 concentrations similar to those of the Ovx hamsters receiving the control diet. Non-HDL- @entity0 concentrations were lowest in the @entity4 group, albeit not statistically different from the other treatment groups. There were no significant differences among groups in serum @entity2 concentration and liver lipids. Both @entity4 and FO more than doubled the hepatic protein levels of 7a-hydroxylase in comparison to the Ovx hamsters receiving the control diet (P   <   .05). Our findings suggest that increased @entity3 synthesis is one of the major @entity0 -lowering mechanisms of flaxseed and that other flaxseed components, aside from its oil, contribute to its hypocholesterolemic property. The @entity0 -lowering effects of other components of flaxseed and their mechanisms of action need to be further explored.

title: Flaxseed but not flaxseed oil prevented the rise in serum XXXX due to ovariectomy in the Golden @entity1 .

answer: @entity0


abstract: @entity3 ( @entity3 ) is a @entity5 with major features in @entity2 . Recently, diagnostic criteria were revised where more weight was given to the @entity1 . We applied the revised Marfan nosology in an established adult Marfan population to define practical repercussions of novel criteria for clinical practice and individual @entity0 . Out of 180 @entity3 @entity0 , in 91% (n = 164) the diagnosis of @entity3 remained. Out of 16 @entity0 with rejected diagnosis, four @entity0 were diagnosed as MASS ( @entity4 , @entity6 , borderline non-progressive @entity1 , skeletal findings and striae) phenotype, three as @entity8 and in nine @entity0 no alternative diagnosis was established. In 13 @entity0 , the diagnosis was rejected because the Z-score of the aortic root was <2, although the aortic diameter was larger than 40 mm in six of them. In three other @entity0 , the diagnosis of @entity3 was rejected because dural @entity7 was given less weight in the revised nosology. Following the revised Marfan nosology, the diagnosis of @entity3 was rejected in 9% of @entity0 , mostly because of the absence of @entity1 defined as Z-score >= 2. Currently used Z-scores seem to underestimate @entity1 , especially in @entity0 with large body surface area (BSA). We recommend re-evaluation of criteria for aortic root involvement in adult @entity0 with a suspected diagnosis of @entity3 .

title: Critical appraisal of the revised Ghent criteria for diagnosis of XXXX .

answer: @entity3


abstract: Identification of proteins with low sequence coverage using @entity3 ( @entity3 ) requires tandem @entity3 / @entity3 peptide sequencing. It is very challenging to obtain a complete or to interpret an incomplete tandem @entity3 / @entity3 spectrum from fragmentation of a weak peptide ion signal for sequence assignment. Here, we have developed an effective and high-throughput MALDI-TOF-based method for the identification of membrane and other low-abundance proteins with a simple, one-dimensional separation step. In this approach, several stable isotope-labeled @entity2 precursors were selected to mass-tag, in parallel, the @entity0 proteome of @entity0 skin fibroblast cells in a residue-specific manner during in vivo cell culturing. These labeled residues can be recognized by their characteristic isotope patterns in @entity1 spectra. The isotope pattern of particular peptides induced by the different labeled precursors provides information about their @entity2 compositions. The specificity of peptide signals in a peptide mass mapping is thus greatly enhanced, resolving a high degree of mass degeneracy of proteolytic peptides derived from the complex @entity0 proteome. Further, false positive matches in database searching can be eliminated. More importantly, proteins can be accurately identified through a single peptide with its m/z value and partial @entity2 composition. With the increased solubility of hydrophobic proteins in SDS, we have demonstrated that our approach is effective for the identification of membrane and low-abundant proteins with low sequence coverage and weak signal intensity, which are often difficult for obtaining informative fragment patterns in tandem @entity3 / @entity3 peptide sequencing analysis.

title: Single peptide-based protein identification in @entity0 proteome through XXXX coupled with amino acids coded mass tagging.

answer: @entity1


abstract: Identification of proteins with low sequence coverage using @entity3 ( @entity3 ) requires tandem @entity3 / @entity3 peptide sequencing. It is very challenging to obtain a complete or to interpret an incomplete tandem @entity3 / @entity3 spectrum from fragmentation of a weak peptide ion signal for sequence assignment. Here, we have developed an effective and high-throughput MALDI-TOF-based method for the identification of membrane and other low-abundance proteins with a simple, one-dimensional separation step. In this approach, several stable isotope-labeled @entity2 precursors were selected to mass-tag, in parallel, the @entity0 proteome of @entity0 skin fibroblast cells in a residue-specific manner during in vivo cell culturing. These labeled residues can be recognized by their characteristic isotope patterns in @entity1 spectra. The isotope pattern of particular peptides induced by the different labeled precursors provides information about their @entity2 compositions. The specificity of peptide signals in a peptide mass mapping is thus greatly enhanced, resolving a high degree of mass degeneracy of proteolytic peptides derived from the complex @entity0 proteome. Further, false positive matches in database searching can be eliminated. More importantly, proteins can be accurately identified through a single peptide with its m/z value and partial @entity2 composition. With the increased solubility of hydrophobic proteins in SDS, we have demonstrated that our approach is effective for the identification of membrane and low-abundant proteins with low sequence coverage and weak signal intensity, which are often difficult for obtaining informative fragment patterns in tandem @entity3 / @entity3 peptide sequencing analysis.

title: Single peptide-based protein identification in XXXX proteome through @entity1 coupled with amino acids coded mass tagging.

answer: @entity0


abstract: A novel ion source based on the principle of sonic spray ionization has been built and used to optimize mass spectrometric conditions for generating @entity1 clusters. The ion source employs a simple pneumatic spray operated at extremely high nebulizing gas flow rates. Several factors that affect the performance of the cluster source are identified, and information from these observations provides insights into the mechanisms of gas phase ion formation. @entity2 is used as a model system in optimizing instrumental and sample parameters to maximize cluster ion formation. The sonic spray results for this oligomer compare favorably with electrospray data, showing an order of magnitude better signal intensity and excellent signal-to-noise ratios. The performance of the system for the protonated @entity2 octamer includes a limit of detection of 10 nM and a linear dynamic range of 4 orders of magnitude. Ion formation was observed to go into saturation above 1 mM. This result and data on pH, electrolyte concentration, and solvent composition are interpreted as supporting a charge residue model of sonic spray ionization. Other @entity5 can be substituted for @entity2 in the octamer, with a strong chiral preference in favor of homochiral cluster formation in the cases of @entity6 and @entity0 . These @entity5 show a preference for substitution of more than two @entity2 molecules. @entity4 , @entity8 , @entity7 , and @entity3 also substitute into the @entity2 octamer; however, the process yields only two incorporations and only small chiral effects.

title: XXXX clusters formed by sonic spray ionization.

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to assess the association of @entity3 with refractory arterial @entity1 . STUDY DESIGN: A total of 137 @entity0 were examined. Seventy @entity0 (mean age of 55.2        9.2 years) were included in the case group, while 67 non- @entity1 subjects (mean age of 50.0    7.2) served as a control group. Periodontal clinical examination included plaque index, @entity2 on probing, probing pocket depth and clinical @entity4 (CAL). @entity0 with at least five sites with CAL >= 6 mm were considered as severe @entity3 , and with at least 30% of the sites with CAL >= 4   mm generalized @entity5 . RESULTS: The mean (  s.d.) number and percentage of sites with CAL >= 6   mm were 11 (  14) and 16.6 (  14) in the case group, and 5.7 (  9.5) and 5.8 (  9.7) in the control group (P    <   0.05). The mean (  s.d.) percentage of sites with CAL >= 4   mm was 37 (  29.6) in the case group and 21.2 (  20) in the control group (P    <   0.05). The significant associations with arterial @entity1 were severe @entity5 (OR   =   4.04, 95% CI: 1.92; 8.49) and generalized @entity5 (OR   =   2.18, 95% CI: 1.04; 4.56). CONCLUSIONS: Severe and generalized @entity5 seem to play a role as risk indicators for @entity1 @entity0 .

title: Higher prevalence of @entity3 in @entity0 with refractory arterial XXXX : a case-control study.

answer: @entity1


abstract: OBJECTIVE: The aim of this study was to assess the association of @entity3 with refractory arterial @entity1 . STUDY DESIGN: A total of 137 @entity0 were examined. Seventy @entity0 (mean age of 55.2        9.2 years) were included in the case group, while 67 non- @entity1 subjects (mean age of 50.0    7.2) served as a control group. Periodontal clinical examination included plaque index, @entity2 on probing, probing pocket depth and clinical @entity4 (CAL). @entity0 with at least five sites with CAL >= 6 mm were considered as severe @entity3 , and with at least 30% of the sites with CAL >= 4   mm generalized @entity5 . RESULTS: The mean (  s.d.) number and percentage of sites with CAL >= 6   mm were 11 (  14) and 16.6 (  14) in the case group, and 5.7 (  9.5) and 5.8 (  9.7) in the control group (P    <   0.05). The mean (  s.d.) percentage of sites with CAL >= 4   mm was 37 (  29.6) in the case group and 21.2 (  20) in the control group (P    <   0.05). The significant associations with arterial @entity1 were severe @entity5 (OR   =   4.04, 95% CI: 1.92; 8.49) and generalized @entity5 (OR   =   2.18, 95% CI: 1.04; 4.56). CONCLUSIONS: Severe and generalized @entity5 seem to play a role as risk indicators for @entity1 @entity0 .

title: Higher prevalence of XXXX in @entity0 with refractory arterial @entity1 : a case-control study.

answer: @entity3


abstract: OBJECTIVE: The aim of this study was to assess the association of @entity3 with refractory arterial @entity1 . STUDY DESIGN: A total of 137 @entity0 were examined. Seventy @entity0 (mean age of 55.2        9.2 years) were included in the case group, while 67 non- @entity1 subjects (mean age of 50.0    7.2) served as a control group. Periodontal clinical examination included plaque index, @entity2 on probing, probing pocket depth and clinical @entity4 (CAL). @entity0 with at least five sites with CAL >= 6 mm were considered as severe @entity3 , and with at least 30% of the sites with CAL >= 4   mm generalized @entity5 . RESULTS: The mean (  s.d.) number and percentage of sites with CAL >= 6   mm were 11 (  14) and 16.6 (  14) in the case group, and 5.7 (  9.5) and 5.8 (  9.7) in the control group (P    <   0.05). The mean (  s.d.) percentage of sites with CAL >= 4   mm was 37 (  29.6) in the case group and 21.2 (  20) in the control group (P    <   0.05). The significant associations with arterial @entity1 were severe @entity5 (OR   =   4.04, 95% CI: 1.92; 8.49) and generalized @entity5 (OR   =   2.18, 95% CI: 1.04; 4.56). CONCLUSIONS: Severe and generalized @entity5 seem to play a role as risk indicators for @entity1 @entity0 .

title: Higher prevalence of @entity3 in XXXX with refractory arterial @entity1 : a case-control study.

answer: @entity0


abstract: BACKGROUND: A study was undertaken to investigate whether @entity2 ( @entity2 ) injection in lower adipose tissue-containing sites (arms and legs) would result in a lower exposure and reduced stem cell collection efficiency compared with injection into abdominal skin. STUDY DESIGN AND METHODS: We completed a prospective randomized study to determine the efficacy and tolerability of different injection sites for @entity0 with multiple @entity3 or @entity1 undergoing stem cell mobilization and apheresis. Primary endpoints were the number of @entity4 + cells collected and the number of days of apheresis. Forty @entity0 were randomly assigned to receive cytokine injections in their abdomen (Group A) or extremities (Group B). Randomization was stratified based on diagnosis ( @entity3 , n=29 vs. @entity1 , n=11), age, and mobilization strategy and balanced across demographic factors and body mass index. RESULTS: Thirty-five subjects were evaluable for the primary endpoint: 18 in Group A and 17 in Group B. One evaluable subject in each group failed to collect a minimum dose of at least 2.0*10(6) @entity4 + cells/kg. The mean numbers of @entity4 + cells (  SD) collected were not different between Groups A and B (9.15*10(6)  4.7*10(6) /kg vs. 9.85*10(6)   5*10(6) /kg, respectively; p=NS) after a median of 2 days of apheresis. Adverse events were not different between the two groups. CONCLUSION: The site of @entity2 administration does not affect the number of @entity4 + cells collected by apheresis or the duration of apheresis needed to reach the target cell dose.

title: A randomized clinical trial comparing XXXX administration sites for mobilization of peripheral blood stem cells for @entity0 with hematologic malignancies undergoing autologous stem cell transplantation.

answer: @entity2


abstract: BACKGROUND: A study was undertaken to investigate whether @entity2 ( @entity2 ) injection in lower adipose tissue-containing sites (arms and legs) would result in a lower exposure and reduced stem cell collection efficiency compared with injection into abdominal skin. STUDY DESIGN AND METHODS: We completed a prospective randomized study to determine the efficacy and tolerability of different injection sites for @entity0 with multiple @entity3 or @entity1 undergoing stem cell mobilization and apheresis. Primary endpoints were the number of @entity4 + cells collected and the number of days of apheresis. Forty @entity0 were randomly assigned to receive cytokine injections in their abdomen (Group A) or extremities (Group B). Randomization was stratified based on diagnosis ( @entity3 , n=29 vs. @entity1 , n=11), age, and mobilization strategy and balanced across demographic factors and body mass index. RESULTS: Thirty-five subjects were evaluable for the primary endpoint: 18 in Group A and 17 in Group B. One evaluable subject in each group failed to collect a minimum dose of at least 2.0*10(6) @entity4 + cells/kg. The mean numbers of @entity4 + cells (  SD) collected were not different between Groups A and B (9.15*10(6)  4.7*10(6) /kg vs. 9.85*10(6)   5*10(6) /kg, respectively; p=NS) after a median of 2 days of apheresis. Adverse events were not different between the two groups. CONCLUSION: The site of @entity2 administration does not affect the number of @entity4 + cells collected by apheresis or the duration of apheresis needed to reach the target cell dose.

title: A randomized clinical trial comparing @entity2 administration sites for mobilization of peripheral blood stem cells for XXXX with hematologic malignancies undergoing autologous stem cell transplantation.

answer: @entity0


abstract: Obesity is a major health concern not only in the general population but also in @entity0 with @entity3 . Little is known about the consequences of @entity1 for @entity3 @entity0 . As @entity1 is an important risk factor for @entity5 , these effects may be even more pronounced in @entity3 @entity0 who are prone to joint damage. The association between @entity1 and limitations in daily activities as well as the frequency of @entity4 and use of @entity6 ( @entity6 ) concentrate in @entity1 and normal weight @entity3 @entity0 was assessed. Fifteen @entity1 (BMI >=  30 kg m(-2)) and fifteen normal weight (BMI  <= 25 kg m(-2)) @entity3 @entity0 matched for severity and age were analysed. The @entity3 ( @entity3 ) was used to assess the impairment in daily activities. Compared with the normal weight @entity3 @entity0 , @entity1 haemophiliacs had a significantly lower sum score (88/100 and 98/100, respectively, P = 0.02), which was mainly caused by an impaired lower limb function. All other components of the @entity3 also showed lower scores in the @entity1 @entity0 , but did not reach statistical significance. @entity4 requiring treatment with @entity6 concentrate occurred in the @entity1 haemophiliacs (17 @entity4 in eight individuals) compared with the controls (three @entity4 in three individuals) (P = 0.045). Compared with non- @entity1 @entity3 @entity0 , @entity1 haemophiliacs had @entity4 and a lower overall @entity3 score, which was driven by a lower limb function score. Prevention of overweight and @entity2 requires special attention from physicians treating @entity3 @entity0 .

title: The impairment in daily life of XXXX haemophiliacs.

answer: @entity1


abstract: BACKGROUND: Treatment of the Slipped Capital @entity3 remains a cause of concern due to the fact that the true knowledge of the etiopathogeny is unknown, as well as one of its major complications: chondrolysis. The conservative treatment remains controversial; it has been overlooked in the studies and subjected to intense criticism. The purpose of this study is to investigate the results of treatment on the hip of @entity0 @entity3 , using the plaster cast immobilization method and its link to chondrolysis. METHODS: The research was performed based on the study of the following variables: symptomatology, and the degree of slipping. A hip spica cast and bilateral short/long leg casts in abduction, internal rotation with anti-rotational bars were used for immobilizing the @entity0 's hip for twelve weeks. Statistical analysis was accomplished by Wilcoxon's marked position test and by the Fisher accuracy test at a 5% level. RESULTS: A satisfactory result was obtained in the acute group, 70.5%; 94%; in the chronic group (chronic + acute on chronic). Regarding the degree of the slipping, a satisfactory result was obtained in 90.5% of hips tested with a mild slip; in 76% with moderate slip and 73% in the severe slip. The statistical result revealed that a significant improvement was found for flexion (p = 0.0001), abduction (p = 0.0001), internal rotation (p = 0.0001) and external rotation (p = 0.02). Chondrolysis was present in 11.3% of the hips tested. One case of @entity2 with @entity1 was presented. There was no significant variation between age and chondrolysis (p = 1.00).Significant variation between gender/non-white @entity0 versus chondrolysis (p = 0.031) and (p = 0.037), respectively was verified. No causal association between plaster cast and chondrolysis was observed (p = 0.60). In regard to the symptomatology group and the slip degree versus chondrolysis, the p value was not statistically significant in both analyses, p = 0.61 and p = 0.085 respectively. CONCLUSIONS: After analyzing the nonoperative treatment of slipped @entity3 and chondrolysis, we conclude that employment of the treatment revealed that the method was functional, efficient, valid, and reproducible; it also can be used as an alternative therapeutic procedure regarding to this specific disease.

title: Nonoperative treatment of slipped XXXX : a scientific study.

answer: @entity3


abstract: OBJECTIVE: To compare the effectiveness and safety of uterine @entity3 by laparoscopy versus embolization as a treatment modality for symptomatic uterine fibroids. METHODS: Ninety-six premenopausal @entity0 with symptomatic @entity4 were studied. None of them desired further pregnancy. They were randomized to treatment either by laparoscopic occlusion (group 1) or by radiologic embolization of uterine arteries (group 2). The primary outcome measure was @entity0 satisfaction as regards menstrual @entity1 compared with pretreatment loss. Secondary outcome measures included @entity2 , complications, secondary interventions, and failures. RESULTS: Ninety @entity0 were followed for 1, 3, 6, and 12 months after both procedures. The primary outcome was comparable between the 2 groups (86.7% after laparoscopic occlusion versus 88.8% after embolization, with no statistically significant difference). After 12 months of follow-up, more @entity0 resumed heavy periods in the uterine @entity3 group [4/45 @entity0 , 8.8% in occlusion group compared with 3/45 (6.6%) in embolization group, P=0.044]. CONCLUSION: Both laparoscopic occlusion and superselective embolization of uterine arteries improved clinical symptoms in the majority of @entity0 . At 12-month follow-up, embolization might be more effective.

title: Uterine XXXX for treatment of symptomatic uterine myomas.

answer: @entity3


abstract: BACKGROUND: To evaluate the therapeutic effect and acute side-effect of escalated hyperfractionated accelerated radiation therapy (EHART) combined with chemotherapy for stage IIIB @entity3 ( @entity3 ). METHODS: From Aug. 1998 to Aug. 2001, a prospective trial for @entity3 was carried out in 112 @entity0 with stage IIIB. These @entity0 were nonrandomly divided into 2 groups: conventional fractionated radiation therapy group (CFRT 65 cases) and EHART group (47 cases). The CFRT @entity0 were treated by 1.8-2 Gy/fraction per day, 5 treatment days per week; the total doses received in center of @entity1 were 54-70 Gy /27-40 fractions/37-85 days, the median was 60 Gy/30 factions/43 days. The EHART @entity0 were treated by escalated doses: In the first and second weeks, 1.2 Gy/fraction twice a day was given, then 1.3 Gy , 1.4 Gy , and 1.5 Gy from third to fifth weeks respectively, twice fractions a day (over 6 hours interval), 5 treatment days each week, the total doses were 60-66 Gy/46-50 fractions/30-45 days, the median was 66 Gy /50 fractions/34 days. Radiation fields just covered the @entity1 mass which were determined by thoracic CT with 1.5 cm margins. A total of 4-6 cycles chemotherapy with MVP regimen mostly was delivered before (1-2 cycles) and after (3-5 cycles) radiotherapy. Each @entity0 was followed up for 1 year. RESULTS: Seven cases were excluded from EHART, twelve from CFRT. There were 93 @entity0 to be evaluated. The immediate response rate of @entity1 by EHART and CFRT was 72.5% and 64.2% respectively (Chi-square=1.02, P=0.346). The 1-year survival rate was 60.0% and 47.2% respectively (Chi-square=2.56, P=0.107), and the local control rate was 67.5% and 52.8% respectively (Chi-square=3.01, P=0.085). The incidence and degree of @entity4 in EHART were more severe than that in CFRT (Chi-square=5.02, P=0.025). CONCLUSIONS: The treatment effect by EHART for stage IIIB @entity3 is encouraging and its @entity2 could be tolerated by most of @entity0 . It is worthy of further study on survival rate and late complications in long term.

title: [Escalated hyperfractionated accelerated radiation therapy combined with chemotherapy for stage IIIB XXXX ].

answer: @entity3


abstract: BACKGROUND: @entity0 with skull defects sometimes develop @entity3 , which have been grouped under "the syndrome of the trephined". The deficits are usually nonspecific or nonlocalizing, such as apathy or @entity1 . We report, to our knowledge, a first case of severe @entity14 associated with a skull defect. Cranioplasty dramatically resolved the @entity0 's symptoms. A @entity14 represents the main manifestation of the syndrome of the trephined and can be corrected by cranioplasty. CLINICAL PRESENTATION: A 38-year-old @entity0 with @entity9 and @entity15 initially had @entity13 . He developed a skull defect after @entity6 following cranioplasty. He presented with onset of neurological symptoms one year after @entity9 with a skull defect, a small divergent and vertical strabismus, elevation @entity10 , @entity1 and @entity12 . Over several months he developed severe bilateral deficit of adduction, elevation, @entity7 and convergence. He had @entity3 , @entity12 , @entity1 and @entity4 . Neuroimaging and lumbar puncture did not show evidence of @entity8 or @entity11 . INTERVENTION: Cranioplasty using Palacos was performed one-and-a-half years after @entity5 . Immediately after surgery, the @entity0 noted remarkable improvement in his symptoms. @entity1 and @entity12 disappeared within two days. Two weeks after cranioplasty the @entity0 had orthotropia and virtually normal ocular motility. @entity2 completely disappeared. Recovery remained sustained for over 5 years after cranioplasty. CONCLUSION: To our knowledge, this represents the first case of the syndrome of the trephined in which the @entity3 map primarily to the brainstem and show rapid improvement following cranioplasty. We show that cranioplasty in @entity0 with large skull defects is indicated for more then cosmetic reasons and should be considered even after longer periods following a @entity5 .

title: XXXX with @entity13 : dramatic improvement after cranioplasty.

answer: @entity14


abstract: BACKGROUND: @entity0 with skull defects sometimes develop @entity3 , which have been grouped under "the syndrome of the trephined". The deficits are usually nonspecific or nonlocalizing, such as apathy or @entity1 . We report, to our knowledge, a first case of severe @entity14 associated with a skull defect. Cranioplasty dramatically resolved the @entity0 's symptoms. A @entity14 represents the main manifestation of the syndrome of the trephined and can be corrected by cranioplasty. CLINICAL PRESENTATION: A 38-year-old @entity0 with @entity9 and @entity15 initially had @entity13 . He developed a skull defect after @entity6 following cranioplasty. He presented with onset of neurological symptoms one year after @entity9 with a skull defect, a small divergent and vertical strabismus, elevation @entity10 , @entity1 and @entity12 . Over several months he developed severe bilateral deficit of adduction, elevation, @entity7 and convergence. He had @entity3 , @entity12 , @entity1 and @entity4 . Neuroimaging and lumbar puncture did not show evidence of @entity8 or @entity11 . INTERVENTION: Cranioplasty using Palacos was performed one-and-a-half years after @entity5 . Immediately after surgery, the @entity0 noted remarkable improvement in his symptoms. @entity1 and @entity12 disappeared within two days. Two weeks after cranioplasty the @entity0 had orthotropia and virtually normal ocular motility. @entity2 completely disappeared. Recovery remained sustained for over 5 years after cranioplasty. CONCLUSION: To our knowledge, this represents the first case of the syndrome of the trephined in which the @entity3 map primarily to the brainstem and show rapid improvement following cranioplasty. We show that cranioplasty in @entity0 with large skull defects is indicated for more then cosmetic reasons and should be considered even after longer periods following a @entity5 .

title: @entity14 with XXXX : dramatic improvement after cranioplasty.

answer: @entity13


abstract: OBJECTIVE: To evaluate presenting signs and clinical diagnosis in a cohort of @entity0 referred to rule out @entity2 . METHODS: A retrospective chart review was performed on @entity0 referred to the Cleveland Clinic Foundation between November 1993 and July 2001 to rule out @entity2 . Clinical findings necessary for the diagnosis of the disorder according to current criteria (De Paepe et al., Am J Med Genet. 1996;62:417-426) were determined through complete physical examination and testing, including an echocardiogram and a slit-lamp examination. Information regarding age, sex, reason for evaluation, family history, symptoms, and ultimate clinical diagnosis were extracted from the charts. RESULTS: Seventy-five @entity0 averaging 23.5 years of age completed a comprehensive evaluation to rule out @entity2 . A clinical diagnosis of this condition was made in 28 (37%) @entity0 (12 males, 16 females). Reasons for referral included one or more of the following: (1) the finding by a physician of one or more typical clinical manifestations of the disease; (2) a known family history of the syndrome; and/or (3) curiosity on the part of the @entity0 or family as a result of publicity about @entity2 in lay or medical journals or in television programs. Twenty-eight individuals (37% of the total group) were referred because of skeletal findings common to the syndrome. Of these, 10 (36%) were diagnosed with the disease. Seven (78%) of the nine @entity0 who presented with ocular signs or symptoms were ultimately diagnosed with the disorder. Of the 22 individuals referred because of cardiovascular signs or symptoms, nine (41%) were diagnosed with @entity2 . Twelve (31%) of 39 individuals with a known family history of @entity2 or symptoms common to this condition had a positive diagnosis. Of six individuals evaluated in response to publicity about the disease, two (33%) were ultimately diagnosed with the disorder. CONCLUSION: The most common reasons for evaluation to rule out @entity2 include a positive family history of the condition and the presence of one of its common manifestations (e.g., body habitus, @entity1 , or subluxated lenses). In the present series of @entity0 , the physical finding that predicted the diagnosis most was subluxation of the ocular lens.

title: Presenting signs and clinical diagnosis in individuals referred to rule out XXXX .

answer: @entity2


abstract: The stomach-derived peptide, ghrelin, has recently been discovered as an important regulator of energy homeostasis. Central nervous system pathways involving stimulation of hypothalamic neuropeptides play a prominent role in mediating ghrelin's orexigenic effects. However, potential direct peripheral effects remain poorly understood. Using a brown adipocyte model, we tested ghrelin-mediated influences on adipose tissue. Chronic ghrelin stimulation of differentiating adipocytes did not affect the pattern or extent of fat accumulation. Furthermore, insulin-induced @entity1 uptake as a hallmark of adipocyte function was not altered by ghrelin pre-treatment. However, acute ghrelin treatment resulted in a significant time-dependent increase in p44/42 mitogen-activated protein kinase phosphorylation. There was no stimulation of @entity3 3-kinase, JAK/STAT, or stress kinase signaling pathways. Furthermore, ghrelin did not significantly alter gene expression of the thermogenic uncoupling protein-1. By contrast, expression of the novel adipokine @entity2 , which has been implicated in the pathogenesis of insulin resistance and @entity0 , was strongly impaired. This inhibition occurred acutely, and was sustained for several hours. In summary, our data provide evidence for selective effects of ghrelin on adipocyte signaling and function and thus propose a role for adipose tissue as a novel mediator of ghrelin's effects on energy balance and @entity1 homeostasis.

title: Direct peripheral effects of ghrelin include suppression of XXXX expression.

answer: @entity2


abstract: The adipose tissue renin-angiotensin system has been implicated in the regulation of adipocyte growth and differentiation. We studied the influence of age, body weight, total body fat content, anatomical localization, and diet on the expression of @entity1 ( @entity1 ) and @entity2 genes in white adipose tissue of normal and postnatal overfed @entity0 . Relative gene expression was measured in epididymal adipose tissue and liver of control and postnatal overfed (PNO) @entity0 at the age of 4, 8, and 12 weeks using real time RT-PCR. Body fat content was determined by carcass analysis. Body weight and body fat content were only significantly greater in PNO @entity0 when compared to control @entity0 at the age of 4 weeks. At the age of 12 weeks, @entity1 expression was significantly decreased in both tissues. Furthermore, expression of the AT 1 -receptor gene was significantly decreased in liver but not in adipose tissue at 12 weeks of age. Postnatal overfeeding did not influence the expression levels of either gene at any time-point in either liver or adipose tissue. At the age of 24 weeks, @entity1 expression was significantly greater in epididymal than in subcutaneous adipose tissue, whereas no site-specific differences could be found for the AT 1 -receptor. We conclude that age and depot-specific mechanisms are of more importance for the expression of @entity1 and AT 1 -receptor genes during the first 12 weeks of age than a short period of overfeeding.

title: Age-related changes of Renin-Angiotensin system genes in white adipose tissue of XXXX .

answer: @entity0


abstract: PURPOSE: @entity4 in @entity5 occasionally require surgical treatment due to restricted finger motion and/or @entity2 . However, the @entity0 are growing @entity0 , and the indication for surgical treatment is controversial. We reviewed our cases in order to clarify characteristics of @entity1 and to report surgical outcomes. METHODS: We performed surgeries on 17 @entity4 in the digits of 16 @entity0 . The average age at surgery was 3.6 years. Ten of 16 @entity0 had @entity4 , and 6 @entity0 had been diagnosed with @entity6 . We classified @entity4 into 3 types, according to their locations. Type A is located at the nonepiphyseal metaphysis of the bone (9 lesions), type B in the metaphysis on the epiphyseal plate side (5 lesions), and type C in the diaphysis (3 lesions). Surgery was indicated for either or both restricted motion and @entity2 . Simple excision of the @entity1 was performed in 14 lesions, wedge osteotomy in 2 fingers, and osteotomy with excision of @entity1 in 1 finger. The average follow-up period was 49 months (range, 14-155 mo). RESULTS: Surgical outcomes in types B and C were all good, the deformities were well corrected, and range of motion was improved. On the other hand, in type A, 2 cases still had more than 30   of restricted motion at the final follow-up, and another 2 cases showed more than 10   of @entity2 . CONCLUSIONS: For type A, early surgical treatment is recommended to prevent the progress of the @entity3 and to improve motion. When the @entity1 are oriented more laterally and include less than a third of the joint surface, we recommend sufficient @entity1 excision, which can include part of the articular surface.

title: Surgical treatment for @entity4 in XXXX .

answer: @entity5


abstract: PURPOSE: @entity4 in @entity5 occasionally require surgical treatment due to restricted finger motion and/or @entity2 . However, the @entity0 are growing @entity0 , and the indication for surgical treatment is controversial. We reviewed our cases in order to clarify characteristics of @entity1 and to report surgical outcomes. METHODS: We performed surgeries on 17 @entity4 in the digits of 16 @entity0 . The average age at surgery was 3.6 years. Ten of 16 @entity0 had @entity4 , and 6 @entity0 had been diagnosed with @entity6 . We classified @entity4 into 3 types, according to their locations. Type A is located at the nonepiphyseal metaphysis of the bone (9 lesions), type B in the metaphysis on the epiphyseal plate side (5 lesions), and type C in the diaphysis (3 lesions). Surgery was indicated for either or both restricted motion and @entity2 . Simple excision of the @entity1 was performed in 14 lesions, wedge osteotomy in 2 fingers, and osteotomy with excision of @entity1 in 1 finger. The average follow-up period was 49 months (range, 14-155 mo). RESULTS: Surgical outcomes in types B and C were all good, the deformities were well corrected, and range of motion was improved. On the other hand, in type A, 2 cases still had more than 30   of restricted motion at the final follow-up, and another 2 cases showed more than 10   of @entity2 . CONCLUSIONS: For type A, early surgical treatment is recommended to prevent the progress of the @entity3 and to improve motion. When the @entity1 are oriented more laterally and include less than a third of the joint surface, we recommend sufficient @entity1 excision, which can include part of the articular surface.

title: Surgical treatment for XXXX in @entity5 .

answer: @entity4


abstract: Ten cases of @entity1 which were diagnosed and treated among the outpatients from 1987 through 1999 in a clinic of internal medicine locating at the northern districts of Awaji Island were investigated. The @entity0 were consisted of 8 males and 2 females and their ages ranged from 6 to 69 years old. The infected areas were distributed in hilly districts extending over three towns. The outbreak season was from November through December. The following two facts seemed to be worthy of notice. 1) There was a time lag on the @entity0 's onset among the different years. 2) When the incidences were more than two cases a year, the time difference of onset was within a few days each other. Then the relationship between atmospheric temperature and the date of onset was studied. Meterological observing records at Gunge Ichinomia Town near the northern districts of Awaji Island were investigated into the temperature every 10 days from 1987 to 1999. Average temperature every 10 days including the presumable day when each @entity0 was infected with @entity2 (O.T) ranged between 9.1 degrees C and 13.3 degrees C and in 7 of 10 cases ranged between 11.6 degrees C and 13.3 degrees C. The maximum temperature ranged between 11.3 degrees C and 17.5 degrees C, the minimum one between 6.6 degrees C and 9.1 degrees C. It is likely that the seasonal occurrence of @entity1 greatly depends upon the optimum temperature for the activity of tsutsugamushi mites in these areas. The high titer of serum IgM and IgG antibody to Karp, Gilliam Kato type @entity2 was detected by an immunofluorescense assay (IF) in all cases. IgG antibody, titers fell drastically to 20 or 10 times within a few years but 10 times titer was still detected in three cases in more than ten years. It is suggested that IgG antibody titer more than 10 times in healthy @entity0 indicates the infection in the past and titer more than 20 times implies the infection during the past few years.

title: [ XXXX found in the northern districts of Awaji Island--epidemiological study of the outbreak season temperature].

answer: @entity1


abstract: The hippocampo-parahippocampal area (medial temporal lobe system: MTL) plays an important role on @entity0 memory. Its bilateral damage may produce selective and severe impairment of anterograde and retrograde episodic memory. Our MRI volumetric study of 5 cases of pure MTL @entity2 secondary to herpes simplex @entity1 showed that degree of @entity2 and recovery was significantly correlated with the volume of the remaining or functioning MTL. It has to be kept in mind that MTL is a part of a widely distributed memory system. Our functional imaging studies on verbal memory showed that one of the major @entity0 in this system is the frontal lobe. The most interesting finding in our studies is that the area and pattern of frontal activation changed according to the questions asked. For instance, in short term memory of verbal materials classical speech areas such as Broca's area was activated in conjunction with MTL. In long term verbal memory, activated areas shifted to areas anterior as well as superior to Broca's area. These data suggest that strategy of storing changes over time. Damage to bilateral MTL at an early life seems to impair acquisition of semantic memories such as language, and mathematics, as well as more general knowledge necessary for social life. However, detailed information on this important topic remains scanty.

title: [Hippocampo-parahippocampal area and its role on XXXX memory].

answer: @entity0


abstract: BACKGROUND: Cell numbers in above-ground meristems of plants are thought to be maintained by a feedback loop driven by perception of the glycopeptide ligand @entity4 ( @entity4 ) by the @entity2 ( @entity2 ) receptor kinase and the @entity1 /CORYNE (CRN) receptor-like complex. @entity4 produced in the stem cells at the meristem apex limits the expression level of the stem cell-promoting homeodomain protein @entity3 ( @entity3 ) in the cells beneath, where @entity2 and @entity3 RNA are localized. @entity3 downregulation nonautonomously reduces stem cell proliferation. Overexpression of @entity4 eliminates the stem cells, causing meristem termination, and loss of @entity4 function allows meristem overproliferation. There are many questions regarding the @entity4 / @entity2 interaction, including where in the meristem it occurs, how it is regulated, and how it is that a large range of @entity4 concentrations gives no meristem size phenotype. RESULTS: Here we use genetics and live imaging to examine the cell biology of @entity2 in @entity0 meristematic tissue. We demonstrate that plasma membrane-localized @entity2 is reduced in concentration by @entity4 , which causes trafficking of @entity2 to lytic vacuoles. We find that changes in @entity1 activity have no detectable effects on @entity2 levels. We also find that @entity4 appears to diffuse broadly in meristems, contrary to a recent sequestration model. CONCLUSIONS: This study provides a new model for @entity2 function in plant stem cell maintenance and suggests that downregulation of plasma membrane-localized @entity2 by its @entity4 ligand can account for the buffering of @entity4 signaling in the maintenance of stem cell pools in plants.

title: Plant stem cell signaling involves ligand-dependent trafficking of the XXXX receptor kinase.

answer: @entity2


abstract: PURPOSE: We aimed to evaluate the clinical usefulness and outcome of angiosome-oriented percutaneous transluminal angioplasty (IP-PTA) and its clinical outcome for isolated @entity2 in @entity1 . METHODS: We retrospectively reviewed 70 @entity0 (82 limbs) with @entity1 who had localized disease at the level of the infrapopliteal artery. @entity0 underwent IP-PTA between January 2011 and December 2013 and were followed up for a mean of 13 months. The primary target arterial lesions were chosen according to the angiosome concept. We evaluated clinical findings, technical success, and @entity0 ' clinical outcome. The angiographic outcome of IP-PTA was assessed using the angiosome score. We analyzed the relationship between the angiosome score and the amputation rate. RESULTS: There were 69 anterior tibial artery (ATA) lesions, 70 posterior tibial artery (PTA) lesions, and 58 peroneal artery (PA) lesions. The primary target arteries were the ATA (n=43), PTA (n=26), PA (n=2), and ATA + PTA (n=11). We divided the treated limbs into target (n=63) and nontarget (n=19) groups. The overall initial technical success rate was 91.4%. Successful wound healing rates were 87.3% (55/63) and 47.3% (9/19) in the target and nontarget groups, respectively (P < 0.05). CONCLUSION: Angiosome-oriented primary targeted IP-PTA shows a highly effective treatment outcome in @entity1 . In cases with inadequate angioplastic results of the target artery, IP-PTA of the nontarget artery should be recommended to improve the limb salvage rates.

title: Clinical outcome of angiosome-oriented infrapopliteal percutaneous transluminal angioplasty for isolated XXXX in @entity0 with critical limb ischemia.

answer: @entity2


abstract: PURPOSE: We aimed to evaluate the clinical usefulness and outcome of angiosome-oriented percutaneous transluminal angioplasty (IP-PTA) and its clinical outcome for isolated @entity2 in @entity1 . METHODS: We retrospectively reviewed 70 @entity0 (82 limbs) with @entity1 who had localized disease at the level of the infrapopliteal artery. @entity0 underwent IP-PTA between January 2011 and December 2013 and were followed up for a mean of 13 months. The primary target arterial lesions were chosen according to the angiosome concept. We evaluated clinical findings, technical success, and @entity0 ' clinical outcome. The angiographic outcome of IP-PTA was assessed using the angiosome score. We analyzed the relationship between the angiosome score and the amputation rate. RESULTS: There were 69 anterior tibial artery (ATA) lesions, 70 posterior tibial artery (PTA) lesions, and 58 peroneal artery (PA) lesions. The primary target arteries were the ATA (n=43), PTA (n=26), PA (n=2), and ATA + PTA (n=11). We divided the treated limbs into target (n=63) and nontarget (n=19) groups. The overall initial technical success rate was 91.4%. Successful wound healing rates were 87.3% (55/63) and 47.3% (9/19) in the target and nontarget groups, respectively (P < 0.05). CONCLUSION: Angiosome-oriented primary targeted IP-PTA shows a highly effective treatment outcome in @entity1 . In cases with inadequate angioplastic results of the target artery, IP-PTA of the nontarget artery should be recommended to improve the limb salvage rates.

title: Clinical outcome of angiosome-oriented infrapopliteal percutaneous transluminal angioplasty for isolated @entity2 in XXXX with critical limb ischemia.

answer: @entity0


abstract: This paper reviews literature about oocyte donation for @entity0 with @entity7 and reports the experience of our center. Before contemplating pregnancy, it is essential to perform a careful evaluation of the cardiovascular system, the renal system, the thyroid status and the @entity4 tolerance. Different studies have reported a suboptimal response of the endometrium of @entity0 with @entity7 to @entity8 therapy, and suggested that higher doses of @entity3 may be necessary to achieve appropriate endometrial preparation. Pregnancy rate per transfer following oocyte donation is around 30% for @entity0 with @entity7 , comparable to the one observed for @entity0 with other conditions requiring oocyte donation. Miscarriage rate is however higher (40-50%) after oocyte donation in @entity7 , and could be related to the presence of a hypoplastic uterus along with hypovascularization. During pregnancy, @entity1 are potentially the most severe, such as the exacerbation of a preexisting @entity2 and the dissection of @entity5 . There is a high rate of Caesarean section among @entity7 @entity0 , the main reason being fetopelvic disproportion. Regarding the increased obstetrical risks in @entity7 @entity0 , the selective transfer of one embryo should ideally be performed in order to avoid additional risks associated with @entity6 . In our center, 9 @entity0 with a @entity7 had 15 cycles of oocyte donation. Five pregnancies were obtained among which three were evolutive. The outcome of oocyte donation cycles were comparable for @entity0 with a @entity7 and for @entity0 with other indications of oocyte donation.

title: [ XXXX and oocyte donation].

answer: @entity7


abstract: OBJECTIVE: The objective of the work was to evaluate the incidence and @entity4 after radical exenteration of the axilla in conjunction with an implemented surgical operation. DESIGN: Retrospective clinical study. SETTING: Gynaecological and Obstetric Clinic, First Medical Faculty Charles University and General Faculty Hospital Prague, Apolin  rsk   18, Prague. METHOD: The authors made a retrospective analysis of @entity4 in 116 selected @entity1 , who underwent partial breast surgery or ablation of the breast with dissection of the axilla at the Gynaecological and Obstetric Clinic, First Medical Faculty Charles University and General Faculty Hospital in Prague in 1994-2000 on account of @entity0 and II according to FIGO. The group comprised @entity1 where radiotherapy or chemotherapy of the axilla was not used. The @entity1 were at least 12 months after operation without signs of locoregional relapse of the disease and in the dissected axillary tissue at least 10 lymph nodes were found. The operations were implemented by nine different surgeons. Early ( @entity5 , haematoma) as well as late ( @entity2 , paraesthesia, @entity7 , @entity3 , @entity6 ) complications were also evaluated. The authors compared the incidence of complaints in relation to age, the number of dissected nodes and extent of the breast surgery. The statistical significance of the phenomena was evaluated by Fisher's exact test. RESULTS: At least one complication was recorded in 65% of the @entity1 . In early complications (haematoma, @entity5 ) neither the correlation with the @entity1 's age nor with the number of removed nodes was significant. There was a statistically significant relationship (P < 0.05) between the incidence of @entity5 and the extent of the breast surgery which probably was associated with the wound area. As to late complications ( @entity2 , paraesthesia, @entity7 , @entity3 and @entity6 ) a significant relationship was found with lower @entity3 in @entity1 above 55 years (P < 0.05) and lower sensation of weakness and paraesthesias in @entity1 with partial breast operations (P < 0.05). The more frequent complaints of younger @entity1 were probably due to their greater everyday physical activity as compared with older @entity1 . The higher number of subjective complications in @entity1 after ablation of the breast is explained not only by the size of the wound area but also by psychosocial reasons. CONCLUSION: Dissection of the axilla is part of standard surgical treatment of @entity0 . The surgical operation without radio- or chemotherapy is associated in 65% cases with long-term morbidity of the @entity1 . With regard to the shift of diagnosis of @entity0 to earlier stages it is important to seek a less invasive staging method which will reduce the @entity1 's morbidity. The sentinel node biopsy method seems perspective.

title: [Complications of axillary dissection in XXXX ].

answer: @entity0


abstract: UNASSIGNED: @entity2 (NE) is a neuromodulator that can effect long-lasting changes in synaptic strength such as long-term potentiation (LTP), a putative cellular mechanism for memory formation in the @entity0 brain. Persistent LTP requires alterations in gene expression that may involve epigenetic mechanisms such as DNA methylation, histone acetylation, and histone phosphorylation. It is known that beta-adrenergic receptors and NE can boost LTP maintenance by regulating translation. However, it is unclear whether NE can additionally engage epigenetic mechanisms to regulate transcription and boost LTP endurance. To address this issue, we probed NE-treated @entity1 hippocampal slices with pharmacological inhibitors targeting epigenetic regulatory pathways and discovered that NE activates beta-adrenergic receptors to boost LTP maintenance in area @entity3 through DNA methylation and post-translational histone modifications. Specifically, NE paired with 100-Hz stimulation enhanced histone H3 acetylation and phosphorylation, both of which were required for NE-induced boosting of LTP maintenance. Together, our findings identify NE as a neuromodulatory transmitter capable of triggering epigenetic, transcriptional control of genes required for establishing persistent LTP in the @entity1 hippocampus. These modifications may contribute to the stabilization of memory. This article is protected by copyright. All rights reserved.

title: XXXX goes nuclear: Epigenetic modifications during long-lasting synaptic potentiation triggered by activation of beta-adrenergic receptors.

answer: @entity2


abstract: UNASSIGNED: This study was carried out to investigate the effects of @entity7 (TB) on the growth performance, pro-inflammatory cytokines, intestinal morphology, energy status, disaccharidase activity, and antioxidative capacity of broilers challenged with lipopolysaccharide (LPS). A total of 160 one-day-old Cobb broilers were allocated to 1 of 4 treatments, with 4 replicated pens per treatment and 10 birds per pen. The experiment consisted of a 2*2 factorial arrangements of treatments with TB supplementation (0 or 500 mg/kg) and LPS challenge (0 or 500  g/kg body weight [BW]). On days 22, 24, and 26 of the trial, broilers received an intraperitoneal administration of 500  g/kg BW LPS or saline. Dietary TB showed no effect on growth performance. However, LPS challenge decreased the average daily gain of broilers from day 22 to day 26 of the trial. Dietary TB supplementation inhibited the increase of @entity4 (in the jejunum and ileum), @entity0 (in the duodenum and jejunum), and @entity5 (in the duodenum) of LPS-challenged broilers. Similar inhibitory effects of TB in the activities of total @entity1 synthase (in the ileum) and inducible @entity1 synthase (in the jejunum) were also observed in birds challenged with LPS. Additionally, TB supplementation mitigated the decrease of ileal @entity2 , @entity3 and total @entity6 and the reduction of jejunal catalase activity induced by LPS. Taken together, these results suggest that the TB supplementation was able to reduce the release of pro-inflammatory cytokines and improve the energy status and anti-oxidative capacity in the small intestine of LPS-challenged broilers.

title: Effects of XXXX on Intestinal Energy Status, Antioxidative Capacity and Immune Response to Lipopolysaccharide Challenge in Broilers.

answer: @entity7


abstract: A study was conducted using the ileal digestibility technique with grower-finisher @entity5 to evaluate the effects of particle size reduction of @entity2 meal (SBM) on @entity0 and energy digestibility. @entity2 meal was processed through a hammer mill to achieve average particle sizes of 900, 600, 300, and 150 microm. The treatments included the use of two @entity2 meal sources and soy protein concentrate. One source of SBM was ground to four different particle sizes (i.e., 949, 600, 389, 185); a second source was a common SBM source used in other trials (i.e., 800 microm). The soy protein concentrate had an average particle size of 385 microm. A low-protein (5% casein) diet was fed to determine endogenous @entity0 losses. This experiment was conducted in a 7 x 7 Latin Square design in two replicates using 14 crossbred barrows ([Landrace x Yorkshire] x Duroc) that averaged 28 kg BW and 60 d of age. Animals were surgically fitted with a @entity4 at the distal ileum. Treatment diets were fed in meal form, initially at 0.09 kg BW(0.75) and at graded increases at each subsequent period. @entity5 within replicate were fed a constant quantity of their treatment diet for a 5-d adjustment period followed by a 2-d collection of ileal digesta samples. Apparent and true digestibility of @entity3 was calculated by use of @entity8 (0.5%) as an indigestible marker. Apparent digestibility of @entity9 , @entity6 , @entity1 , and @entity7 increased linearly (P < 0.05) as particle size decreased. True digestibility of @entity9 , @entity6 , @entity1 , and @entity7 increased linearly (P < 0.05) as particle size decreased. When the essential @entity3 were averaged, apparent digestibility increased (P < 0.10) from 83.5% to 84.9% as particle size decreased, whereas, nonessential @entity0 digestibility increased only slightly (P > 0.15). Essential @entity0 true digestibility increased numerically from 91.0% to 92.4% as particle size decreased. Energy digestibility was not affected by particle size (P > 0.15). These results suggest that a reduction in particle size of @entity2 meal resulted in a small increase in the digestibility of its @entity3 with the essential @entity3 being affected more than the nonessential @entity3 . The largest improvement in digestibility, however, was obtained when the particle size was reduced to 600 microm.

title: Effect of XXXX meal particle size on @entity0 and energy digestibility in grower-finisher @entity5 .

answer: @entity2


abstract: A study was conducted using the ileal digestibility technique with grower-finisher @entity5 to evaluate the effects of particle size reduction of @entity2 meal (SBM) on @entity0 and energy digestibility. @entity2 meal was processed through a hammer mill to achieve average particle sizes of 900, 600, 300, and 150 microm. The treatments included the use of two @entity2 meal sources and soy protein concentrate. One source of SBM was ground to four different particle sizes (i.e., 949, 600, 389, 185); a second source was a common SBM source used in other trials (i.e., 800 microm). The soy protein concentrate had an average particle size of 385 microm. A low-protein (5% casein) diet was fed to determine endogenous @entity0 losses. This experiment was conducted in a 7 x 7 Latin Square design in two replicates using 14 crossbred barrows ([Landrace x Yorkshire] x Duroc) that averaged 28 kg BW and 60 d of age. Animals were surgically fitted with a @entity4 at the distal ileum. Treatment diets were fed in meal form, initially at 0.09 kg BW(0.75) and at graded increases at each subsequent period. @entity5 within replicate were fed a constant quantity of their treatment diet for a 5-d adjustment period followed by a 2-d collection of ileal digesta samples. Apparent and true digestibility of @entity3 was calculated by use of @entity8 (0.5%) as an indigestible marker. Apparent digestibility of @entity9 , @entity6 , @entity1 , and @entity7 increased linearly (P < 0.05) as particle size decreased. True digestibility of @entity9 , @entity6 , @entity1 , and @entity7 increased linearly (P < 0.05) as particle size decreased. When the essential @entity3 were averaged, apparent digestibility increased (P < 0.10) from 83.5% to 84.9% as particle size decreased, whereas, nonessential @entity0 digestibility increased only slightly (P > 0.15). Essential @entity0 true digestibility increased numerically from 91.0% to 92.4% as particle size decreased. Energy digestibility was not affected by particle size (P > 0.15). These results suggest that a reduction in particle size of @entity2 meal resulted in a small increase in the digestibility of its @entity3 with the essential @entity3 being affected more than the nonessential @entity3 . The largest improvement in digestibility, however, was obtained when the particle size was reduced to 600 microm.

title: Effect of @entity2 meal particle size on XXXX and energy digestibility in grower-finisher @entity5 .

answer: @entity0


abstract: A study was conducted using the ileal digestibility technique with grower-finisher @entity5 to evaluate the effects of particle size reduction of @entity2 meal (SBM) on @entity0 and energy digestibility. @entity2 meal was processed through a hammer mill to achieve average particle sizes of 900, 600, 300, and 150 microm. The treatments included the use of two @entity2 meal sources and soy protein concentrate. One source of SBM was ground to four different particle sizes (i.e., 949, 600, 389, 185); a second source was a common SBM source used in other trials (i.e., 800 microm). The soy protein concentrate had an average particle size of 385 microm. A low-protein (5% casein) diet was fed to determine endogenous @entity0 losses. This experiment was conducted in a 7 x 7 Latin Square design in two replicates using 14 crossbred barrows ([Landrace x Yorkshire] x Duroc) that averaged 28 kg BW and 60 d of age. Animals were surgically fitted with a @entity4 at the distal ileum. Treatment diets were fed in meal form, initially at 0.09 kg BW(0.75) and at graded increases at each subsequent period. @entity5 within replicate were fed a constant quantity of their treatment diet for a 5-d adjustment period followed by a 2-d collection of ileal digesta samples. Apparent and true digestibility of @entity3 was calculated by use of @entity8 (0.5%) as an indigestible marker. Apparent digestibility of @entity9 , @entity6 , @entity1 , and @entity7 increased linearly (P < 0.05) as particle size decreased. True digestibility of @entity9 , @entity6 , @entity1 , and @entity7 increased linearly (P < 0.05) as particle size decreased. When the essential @entity3 were averaged, apparent digestibility increased (P < 0.10) from 83.5% to 84.9% as particle size decreased, whereas, nonessential @entity0 digestibility increased only slightly (P > 0.15). Essential @entity0 true digestibility increased numerically from 91.0% to 92.4% as particle size decreased. Energy digestibility was not affected by particle size (P > 0.15). These results suggest that a reduction in particle size of @entity2 meal resulted in a small increase in the digestibility of its @entity3 with the essential @entity3 being affected more than the nonessential @entity3 . The largest improvement in digestibility, however, was obtained when the particle size was reduced to 600 microm.

title: Effect of @entity2 meal particle size on @entity0 and energy digestibility in grower-finisher XXXX .

answer: @entity5


abstract: In a 10-year period, 108 unstable @entity5 involving the thoracolumbar junction (T11 to L2) were treated. This study evaluates the influence of the different treatments on the rate of complication, reduction of the @entity5 , and neurological recovery. METHODS: mechanism of injury, initial treatment and delay, @entity1 , operative findings, and duration of hospitalization were recorded. X-rays were reviewed for classification of @entity5 , measurement of deformity, and for instability scoring according to @entity2 . Seventy-seven @entity0 were examined and nine more interviewed by telephone. RESULTS: a @entity6 occurred in 65% and a @entity5 in 29%. A laminectomy was performed in 30 @entity0 and Harrington instrumentation and fusion in 71 @entity0 . Sixteen @entity0 were treated conservatively. Fifty-five @entity0 presented either a complete or partial @entity1 . Seventy-five complications were noted and were more frequent in the laminectomy group. The instrumented group showed a clear tendency for earlier ambulation and discharge and @entity4 level was found to be less. An @entity3 was found in @entity0 treated by laminectomy, short fusion, and by nonsurgical modality. The neurologic recovery in the laminectomy and the nonlaminectomy group was not significantly different. Spinal realignment was better in the group where an instrumentation of five levels or more was performed and where posterior elements were not removed by laminectomy.

title: Unstable XXXX of the thoracolumbar spine: a 10-year experience at Sacr  -Coeur Hospital.

answer: @entity5


abstract: UNASSIGNED: BACKGROUND MicroRNA (miR) has been proved to be an important biomarker for @entity1 because it can regulate occurrence, progression, invasion, and @entity0 of @entity1 . A previous study has shown the involvement of @entity9 in multiple @entity7 . Its detailed role and immune regulatory function in @entity3 , however, remains unknown. This study thus investigated the effect of @entity9 in regulating growth, proliferation, and invasion of @entity1 and its influence on cytokine secretion. MATERIAL AND METHODS @entity3 cell line EC9706 and normal esophageal epithelial cell line HEEC were transfected with @entity9 inhibitor. @entity2 assay was used to quantify the cell proliferation, and a Transwell chamber was used to evaluate cell invasion. Release of cytokines, including @entity6 ( @entity6 ), @entity8 , @entity5 , and @entity4 ( @entity4 ), was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS @entity9 expression was significantly elevated in @entity3 cells (p<0.05). The specific inhibition of @entity9 expression remarkably suppressed proliferation and invasion of @entity1 cells. It can also down-regulated @entity6 and @entity4 expression and facilitate secretion of @entity8 and @entity5 when compared to the control group (p<0.05 in all ceases). CONCLUSIONS The inhibition of @entity9 can effectively inhibit @entity1 progression and improve immune function, suggesting its potency as a novel drug target for @entity1 treatment.

title: Effect of XXXX Down-Regulation on Growth and Invasion of @entity3 and Related Immune Function.

answer: @entity9


abstract: UNASSIGNED: BACKGROUND MicroRNA (miR) has been proved to be an important biomarker for @entity1 because it can regulate occurrence, progression, invasion, and @entity0 of @entity1 . A previous study has shown the involvement of @entity9 in multiple @entity7 . Its detailed role and immune regulatory function in @entity3 , however, remains unknown. This study thus investigated the effect of @entity9 in regulating growth, proliferation, and invasion of @entity1 and its influence on cytokine secretion. MATERIAL AND METHODS @entity3 cell line EC9706 and normal esophageal epithelial cell line HEEC were transfected with @entity9 inhibitor. @entity2 assay was used to quantify the cell proliferation, and a Transwell chamber was used to evaluate cell invasion. Release of cytokines, including @entity6 ( @entity6 ), @entity8 , @entity5 , and @entity4 ( @entity4 ), was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS @entity9 expression was significantly elevated in @entity3 cells (p<0.05). The specific inhibition of @entity9 expression remarkably suppressed proliferation and invasion of @entity1 cells. It can also down-regulated @entity6 and @entity4 expression and facilitate secretion of @entity8 and @entity5 when compared to the control group (p<0.05 in all ceases). CONCLUSIONS The inhibition of @entity9 can effectively inhibit @entity1 progression and improve immune function, suggesting its potency as a novel drug target for @entity1 treatment.

title: Effect of @entity9 Down-Regulation on Growth and Invasion of XXXX and Related Immune Function.

answer: @entity3


abstract: We have reviewed, retrospectively, all @entity0 with a @entity5 who underwent an acute correction and lengthening with a monolateral fixator between 1987 and 1996. The @entity0 were all under the age of 19 years and had a minimum follow-up of eight months after removal of the fixator. A total of 41 @entity0 had 57 corrections and lengthening. Their mean age was 11.3 years (3.2 to 18.7) and there were 23 @entity0 and 18 @entity0 . The mean maximum correction in any one plane was 23 degrees (7 to 45). In 41 bony segments (either femur or @entity3 ) a uniplanar correction was made while various combinations were carried out in 16. The site of the osteotomy was predominantly diaphyseal, at a mean of 47% (17% to 73%) of the total bone length and the mean length gained was 6.4 cm (1.0 to 17.0). Univariate analysis identified a moderately strong relationship between the bone healing index (BHI), length gained, maximum correction and grade-II to grade-III complications. For logistic regression analysis the @entity0 were binary coded into two groups; those with a good outcome (BHI < or = 45 days/cm) and those with a poor outcome (BHI > 45 days/cm). Various factors which may influence the outcome were then analysed by calculating odds ratios with 95% confidence intervals. This analysis suggested a dose response between increasing angular correction and poor BHI which only reached statistical significance for corrections of larger magnitude. Longer lengthenings were associated with a better BHI while age and the actual bone lengthened had little effect. Those @entity0 with a maximum angulatory correction of less than 30 degrees in any one plane had an acceptable consolidation time with few major complications. The technique is suitable for @entity1 and @entity4 , but should be used with care in the @entity3 since the risk of a @entity2 or neurapraxia is much greater.

title: Acute correction of XXXX and simultaneous lengthening with a monolateral fixator.

answer: @entity5


abstract: UNASSIGNED: : Although safe, recent clinical trials using autologous bone marrow or peripheral blood cells to treat @entity3 ( @entity3 ) show controversial results. These discrepancies are likely caused by factors such as aging, systemic @entity1 , and cell processing procedures, all of which might impair the regenerative capability of the cells used. Here, we tested whether injection of @entity0 cord blood mononuclear cells (CB-MNCs) combined with hyaluronan (HA) hydrogel improves cell therapy efficacy in a @entity6 @entity3 model. A total of 34 minipigs were divided into 5 groups: sham operation (Sham), surgically induced- @entity3 plus injection with normal saline ( @entity3 +NS), HA only ( @entity3 +HA), CB-MNC only ( @entity3 +CB-MNC), or CB-MNC combined with HA ( @entity3 +CB-MNC/HA). Two months after the surgery, injection of @entity3 +CB-MNC/HA showed the highest left ventricle ejection fraction (51.32%    0.81%) compared with @entity3 +NS (42.87%    0.97%, p < .001), @entity3 +HA (44.2%    0.63%, p < .001), and @entity3 +CB-MNC (46.17%    0.39%, p < .001) groups. The hemodynamics data showed that @entity3 +CB-MNC/HA improved the systolic function (+dp/dt) and diastolic function (-dp/dt) as opposed to the other experimental groups, of which the CB-MNC alone group only modestly improved the systolic function (+dp/dt). In addition, CB-MNC alone or combined with HA injection significantly decreased the scar area and promoted angiogenesis in the infarcted region. Together, these results indicate that combined CB-MNC and HA treatment improves heart performance and may be a promising treatment for @entity4 . SIGNIFICANCE: This study using healthy @entity0 cord blood mononuclear cells (CB-MNCs) to treat @entity3 provides preclinical evidence that combined injection of hyaluronan and @entity0 CB-MNCs after @entity3 significantly increases cell retention in the peri- @entity5 area, improves cardiac performance, and prevents @entity2 . Moreover, using healthy cells to replace dysfunctional autologous cells may constitute a better strategy to achieve heart repair and regeneration.

title: Injection of @entity0 Cord Blood Cells With Hyaluronan Improves Postinfarction Cardiac Repair in XXXX .

answer: @entity6


abstract: UNASSIGNED: : Although safe, recent clinical trials using autologous bone marrow or peripheral blood cells to treat @entity3 ( @entity3 ) show controversial results. These discrepancies are likely caused by factors such as aging, systemic @entity1 , and cell processing procedures, all of which might impair the regenerative capability of the cells used. Here, we tested whether injection of @entity0 cord blood mononuclear cells (CB-MNCs) combined with hyaluronan (HA) hydrogel improves cell therapy efficacy in a @entity6 @entity3 model. A total of 34 minipigs were divided into 5 groups: sham operation (Sham), surgically induced- @entity3 plus injection with normal saline ( @entity3 +NS), HA only ( @entity3 +HA), CB-MNC only ( @entity3 +CB-MNC), or CB-MNC combined with HA ( @entity3 +CB-MNC/HA). Two months after the surgery, injection of @entity3 +CB-MNC/HA showed the highest left ventricle ejection fraction (51.32%    0.81%) compared with @entity3 +NS (42.87%    0.97%, p < .001), @entity3 +HA (44.2%    0.63%, p < .001), and @entity3 +CB-MNC (46.17%    0.39%, p < .001) groups. The hemodynamics data showed that @entity3 +CB-MNC/HA improved the systolic function (+dp/dt) and diastolic function (-dp/dt) as opposed to the other experimental groups, of which the CB-MNC alone group only modestly improved the systolic function (+dp/dt). In addition, CB-MNC alone or combined with HA injection significantly decreased the scar area and promoted angiogenesis in the infarcted region. Together, these results indicate that combined CB-MNC and HA treatment improves heart performance and may be a promising treatment for @entity4 . SIGNIFICANCE: This study using healthy @entity0 cord blood mononuclear cells (CB-MNCs) to treat @entity3 provides preclinical evidence that combined injection of hyaluronan and @entity0 CB-MNCs after @entity3 significantly increases cell retention in the peri- @entity5 area, improves cardiac performance, and prevents @entity2 . Moreover, using healthy cells to replace dysfunctional autologous cells may constitute a better strategy to achieve heart repair and regeneration.

title: Injection of XXXX Cord Blood Cells With Hyaluronan Improves Postinfarction Cardiac Repair in @entity6 .

answer: @entity0


abstract: Managing cervical lymph node @entity1 in @entity3 with either "berry picking" (BP) or anatomic neck dissection (AND) has not been shown to alter survival. Nevertheless local control of @entity3 is important. The purpose of this study is to determine whether the local recurrence rate of @entity3 is equivalent with BP versus AND. A retrospective analysis revealed 41 @entity0 with @entity3 and cervical node @entity1 seen by a single surgeon from 1985 to 2002. A total of 83 initial and repeat neck operations were performed (nine BPs, 30 central neck dissections, and 44 modified radical neck dissections). Recurrence of @entity2 , intervention for recurrence, and complications of the BP and AND groups were evaluated. All nine (100%) @entity0 undergoing a limited BP operation had local recurrence of @entity2 . Only three of the 32 (9%) @entity0 undergoing an initial formal neck operation had local recurrence of @entity2 . The recurrences after BP (100%) were significantly greater than the recurrences after AND (9%) (P < 0.001). The incidence of surgical complications with BP and AND was not different. Six of 32 (19%) initial formal neck dissection @entity0 and four of nine (44%) BP @entity0 had surgical complications. We conclude that BP is associated with greater local recurrence of @entity3 . @entity0 with nodal @entity1 should be managed with ANDs.

title: Greater local recurrence occurs with "berry picking" than neck dissection in XXXX .

answer: @entity3


abstract: BACKGROUND: Post-operative @entity5 is a common and most often transient event afterextensive thyroid surgery. It may be due to iatrogenic @entity6 . AIMS: We carried out a study aimed to evaluate the incidence of @entity5 and @entity1 following extracapsular total thyroidectomy. METHODS: The study was carried out in 312 @entity0 (273 females and 39 males, whose age was between 23 and 76 years, median age 48.61 +/- 14.1) who had undergone total thyroidectomy (TT) in our department from 1995 to 1998 and in 100 @entity0 (72 females and 28 males, whose age was between 24 and 75 years, median age 51.66 +/- 13.4) who had undergone other (non-thyroid) surgery. RESULTS: Post-operative @entity5 was observed in 62 @entity0 of the control group (62%) and the decrease of the serum @entity2 level lasted about 3 days, and went back to normal within the 5th day. In 2 @entity0 undergoing total thyroidectomy, @entity5 was considered severe (confirmed for more than 7 days, symptomatic), these had been operated for large @entity4 with mediastinal extension. In these @entity0 the symptoms arose acutely about 5 h after the operation. In both cases the clinical and biological aspects went back to normal within 10 days, after a treatment with @entity2 and @entity3 . Transient asymptomatic @entity5 was observed in 234 thyroidectomized @entity0 (75%) and thus did not need any treatment for it. CONCLUSION: The results obtained confirm that transient @entity5 can be observed after any operation; and particularly responsible is the decrease of the @entity2 concerning the proteins. We found that post-operative @entity1 is due to @entity6 (parathyroid ischaemia or surgical ablation of one or more glands). Here we see the delayed serum @entity2 level < or = 7.5 mg/dl or the delayed serum phosphorous level > 7.4 mg/dl. The results of our study, with 2 @entity0 presenting transient post-operative @entity1 , contribute in confirming that the extracapsular total thyroidectomy aimed to reduce any @entity6 and to the recurrent nerves, represent the better operation also for the extended benignant thyroidopathies.

title: XXXX and @entity1 after total thyroidectomy: a clinical biological study and surgical considerations.

answer: @entity5


abstract: BACKGROUND: Post-operative @entity5 is a common and most often transient event afterextensive thyroid surgery. It may be due to iatrogenic @entity6 . AIMS: We carried out a study aimed to evaluate the incidence of @entity5 and @entity1 following extracapsular total thyroidectomy. METHODS: The study was carried out in 312 @entity0 (273 females and 39 males, whose age was between 23 and 76 years, median age 48.61 +/- 14.1) who had undergone total thyroidectomy (TT) in our department from 1995 to 1998 and in 100 @entity0 (72 females and 28 males, whose age was between 24 and 75 years, median age 51.66 +/- 13.4) who had undergone other (non-thyroid) surgery. RESULTS: Post-operative @entity5 was observed in 62 @entity0 of the control group (62%) and the decrease of the serum @entity2 level lasted about 3 days, and went back to normal within the 5th day. In 2 @entity0 undergoing total thyroidectomy, @entity5 was considered severe (confirmed for more than 7 days, symptomatic), these had been operated for large @entity4 with mediastinal extension. In these @entity0 the symptoms arose acutely about 5 h after the operation. In both cases the clinical and biological aspects went back to normal within 10 days, after a treatment with @entity2 and @entity3 . Transient asymptomatic @entity5 was observed in 234 thyroidectomized @entity0 (75%) and thus did not need any treatment for it. CONCLUSION: The results obtained confirm that transient @entity5 can be observed after any operation; and particularly responsible is the decrease of the @entity2 concerning the proteins. We found that post-operative @entity1 is due to @entity6 (parathyroid ischaemia or surgical ablation of one or more glands). Here we see the delayed serum @entity2 level < or = 7.5 mg/dl or the delayed serum phosphorous level > 7.4 mg/dl. The results of our study, with 2 @entity0 presenting transient post-operative @entity1 , contribute in confirming that the extracapsular total thyroidectomy aimed to reduce any @entity6 and to the recurrent nerves, represent the better operation also for the extended benignant thyroidopathies.

title: @entity5 and XXXX after total thyroidectomy: a clinical biological study and surgical considerations.

answer: @entity1


abstract: BACKGROUND: @entity3 remains the most dreaded part of haemorrhoidectomy in the minds of both @entity0 and doctors. It may delay @entity0 discharge, recovery, and return to work. @entity4 has been used successfully in the treatment of anal fissures. We investigated its topical use in the management of @entity2 after haemorrhoidectomy. METHOD: Twenty @entity0 were entered into a double-blind trial and randomised into two groups. Group A (n = 10) applied @entity4 ointment (0.2% twice daily) to the perianal area following surgery, and Group B applied a placebo ointment. They applied the ointment for up to 42 days after surgery, or until they felt it necessary to stop the treatment. @entity0 scored their daily anal @entity2 using a visual analogue scale. Six weeks after surgery, @entity0 were reviewed by an independent observer. RESULTS: The total @entity2 score was calculated for each @entity0 . The median score for Group A was 50.65; the median score for Group B was 73.50. There was no significant difference in @entity2 scores between both groups, even when aberrant results were ignored. 20% of @entity0 in each group complained that the ointment caused @entity1 . CONCLUSION: The results suggest that topical @entity4 ointment may not significantly reduce @entity3 following haemorrhoidectomy. Meta-analysis would provide a more definitive answer.

title: Initial study to assess the effects of topical @entity4 for XXXX after haemorrhoidectomy.

answer: @entity2


abstract: BACKGROUND: @entity3 remains the most dreaded part of haemorrhoidectomy in the minds of both @entity0 and doctors. It may delay @entity0 discharge, recovery, and return to work. @entity4 has been used successfully in the treatment of anal fissures. We investigated its topical use in the management of @entity2 after haemorrhoidectomy. METHOD: Twenty @entity0 were entered into a double-blind trial and randomised into two groups. Group A (n = 10) applied @entity4 ointment (0.2% twice daily) to the perianal area following surgery, and Group B applied a placebo ointment. They applied the ointment for up to 42 days after surgery, or until they felt it necessary to stop the treatment. @entity0 scored their daily anal @entity2 using a visual analogue scale. Six weeks after surgery, @entity0 were reviewed by an independent observer. RESULTS: The total @entity2 score was calculated for each @entity0 . The median score for Group A was 50.65; the median score for Group B was 73.50. There was no significant difference in @entity2 scores between both groups, even when aberrant results were ignored. 20% of @entity0 in each group complained that the ointment caused @entity1 . CONCLUSION: The results suggest that topical @entity4 ointment may not significantly reduce @entity3 following haemorrhoidectomy. Meta-analysis would provide a more definitive answer.

title: Initial study to assess the effects of topical XXXX for @entity2 after haemorrhoidectomy.

answer: @entity4


abstract: OBJECTIVE: @entity4 ( @entity4 ) is highly prevalent in @entity0 with @entity5 ( @entity5 ), owing to clustering of traditional and uremic-specific risk factors. However, in this population asymptomatic course of @entity4 is common and it has been reported that myocardial perfusion imaging (MPI) with single-photon emission tomography (SPET) has lower sensitivity. In the current study, we assessed the value of MPI gated-SPET and its combination with coronary artery @entity6 (CAC) score measurements in risk stratification of @entity5 @entity0 . MATERIALS AND METHODS: MPI gated-SPET was performed with dual-headed SPET camera and CAC score measured by multi-detector computed tomography (MDCT) system.There were tested 77 @entity5 individuals. During the follow-up study, @entity3 ( @entity3 ) defined as @entity2 or nonfatal @entity7 ( @entity7 ) or the necessity for coronary revascularization were recorded. Univariate and stepwise multivariable Cox proportional hazards-models were used to identify the predictors of @entity3 . RESULTS: Eighteen @entity3 were recorded during the follow-up. They were significantly associated with higher summed stress scores on MPI, higher percentage of @entity8 , higher occurrence of defects in multiple territories and higher CAC score (all with P<0.05). Univariate Cox proportional hazard-models showed that severe perfusion abnormalities as well as CAC score >= 1000 were significantly associated with @entity3 (P<0.0001, P=0.0056). In stepwise Cox proportional hazards-models considering age, gender, history of @entity1 , post-stress left ventricular stunning, the degree of perfusion abnormality and CAC score, only severe perfusion abnormalities and CAC score >= 1000 were independent predictors of @entity3 . There was no @entity3 in @entity0 with normal perfusion, normal function and zero CAC score. CONCLUSION: This study suggests that combined evaluation of MPI and CAC can predict the outcome in @entity5 individuals, while severe perfusion abnormality on gated-SPET and high CAC score >= 1000 are predictors of future @entity3 .

title: Prognostic value of myocardial perfusion imaging and coronary artery XXXX measurements in @entity0 with @entity5 .

answer: @entity6